LOCUS       DAEPID010000001       137359 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.001, whole genome shotgun sequence.
ACCESSION   DAEPID010000001 DAEPID010000000
VERSION     DAEPID010000001.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 137359)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 137359)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..137359
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.001"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            complement(<1..972)
                     /locus_tag="KR257_000001"
     CDS             complement(<1..972)
                     /locus_tag="KR257_000001"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891214.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GGDEF domain-containing protein"
                     /protein_id="HBH0028733.1"
                     /translation="MKINKKFNRVDMQVSILTAIIVIISSSCVYFFNYTLTYKSMIYS
                     LSERSKHIYEYVERNIDKNTFTEINSKEDQSKKSYKSSKILLESVKNTTGVMYLYTAK
                     KTKDGSLVYVVDGLNSSRSDFRNAGDLIEKEIWGDLNKALDNHILLPKKIKSTSWGYI
                     FISYFPIHNDVGKVVGVIGIEFEAKHQYNTFKFISIVTPIIALLTCLISALIAVILFK
                     RISNPTYTDFANTDYLTGLKNRNAFEIDMNNLNNSNLKNLISIISIDLDGLKKINDKF
                     GHQTGDLYIKQASKIIQYVINKKYIVYRIGGDEYIIILKNLSHKEINN"
     gene            1471..2832
                     /locus_tag="KR257_000002"
     CDS             1471..2832
                     /locus_tag="KR257_000002"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861729.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MATE family efflux transporter"
                     /protein_id="HBH0028734.1"
                     /translation="MKDRLNLTEGRITEKLLKLSLPIMGTSFIQMGYNMIDMIWVGKA
                     GSKAVAAVGTAGFFPWLAMAFIMISKVGGEIKVAQSIGANNISTTKSYMKSAIEINII
                     LAIIYTISLIVLNKQLIGFFRLGDLEVITMSRQYLIIVALGMVFYFINPVFTAIFNGL
                     GNSKTPFRINTVGLITNIILDPILIFGWGFAPKLGVAGAAIATVFAQIVVTTCFIYII
                     VKSKEEYFKLRLFKEIETKYYKVLYKLGLPIAIQSGMFTVFSMLLGVIVASWGPVAVA
                     VQKVGSQIEAISWMTAEGLSVALGSFVGQNYGAKKYSRINKGCKIAITVSSVLGIITT
                     LVLVFAGESIFSIFIDESEAIEKGAVYLKILGYSQFFMCLEIITTGAFKGLGRTYIPS
                     IIITILTGARVPLAYFISRPEMLGLNGVWWSITLSSILKGILMISLFISLLKLGKLYK
                     ISE"
     gene            2923..3627
                     /locus_tag="KR257_000003"
     CDS             2923..3627
                     /locus_tag="KR257_000003"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426754.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GntR family transcriptional regulator"
                     /protein_id="HBH0028735.1"
                     /translation="MKEPIYKVIENHVRELINSDSLKEGDLIPSEKQLSEEFNVTRMT
                     VRSALNNLVKEGYITRQRGVGSIVIANNIYDNISSVSGFTKEMESKGYKVSNILVSLE
                     IVQADENLSSKLNISLEENVWEIKRVRLANDARVSYMITYMPVKLFPNLNKTHCENSL
                     YNFVEEVCEYKIAMSEREVQAVISNEECMDNLKLEEPEPLLYISQICKLQNSEIFEYS
                     HTYHYGYTLTLNAVVE"
     gene            3827..4138
                     /locus_tag="KR257_000004"
     CDS             3827..4138
                     /locus_tag="KR257_000004"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422688.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIB"
                     /protein_id="HBH0028736.1"
                     /translation="MIKIMLACSAGMSTSLLVTKMEDAAKENGIEAKIWAISEVNLKN
                     EIENCDVLLLGPQVRYVLGKATEMAKPYNIPVEVINMMDYGRCNGKAVLDRAVELNSS
                     K"
     gene            4160..5473
                     /locus_tag="KR257_000005"
     CDS             4160..5473
                     /locus_tag="KR257_000005"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422690.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIC"
                     /protein_id="HBH0028737.1"
                     /translation="MEKFMSFMDKYIVPVAAKIGAQRHLVAVRDAFIVMIPITMVGAL
                     GTLINNLPLEAYKNLMASIFGENWTTFGGDLWWGAIGTMAVFLVIGVAYFLAKSYESD
                     GLQSGLIALSIFFIMAPQIGKIVPEGGTTVVEGWGMIQQTYLGTAALFSSILIGLLST
                     EIFVRLSKVKKLTIKMPDGVPPAVSRSFAKLIPGMLTIMIFTVIGIFIKMLSNGSFLT
                     DILNTYLGAPLSNVADSLGSTMLIAFIIHILWTVGLHGANIALPFTETILMKLGGENA
                     ALAQAGATEGYHVLAGAFFDAFVYLGGSGMVLGLIVALLIAGRRRKEMIVLGGPPAIF
                     NIGEPLIFGLPIVLNPIFMIPFVLAPVICSAVSYLAIDFGLVAPVILPKIPWVTPPIL
                     GGAMATGDWTGGALALFNLILSILIYIPFVIASEKMEANKLKINN"
     gene            5570..6880
                     /locus_tag="KR257_000006"
     CDS             5570..6880
                     /locus_tag="KR257_000006"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861728.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="6-phospho-beta-glucosidase"
                     /protein_id="HBH0028738.1"
                     /translation="MKKGLKIVTIGGGSSYTPELVEGFINRYEELPVKELWLVDIEAG
                     KEKLEIVGNLAKRMVKKAGVDMKINLTLDRREALRDADFVTTQLRVGLLDARIKDETI
                     PLSHGVMGQETNGAGGLFKALRTIPVIFDIIKDVEELCPNAWMVNFTNPTGIITEAVF
                     KYTNFRRYIGLCNVPIHLKNDVAKLFNVESDRISMDFAGLNHMVYGLNVSLDGEDVTK
                     EAIDKFVKADISMQNIKAIDFNAEFVKSLGAIPCPYHRYYYKTKEMLEDELREFKEGK
                     ARGQVVKELEEQLFELYKDEKLDVKPPQLEKRGGAYYSDAACNLISSIYNDKKDIQVV
                     NTLNKGSIRDFKDEQAVEVSSVITKNGPKPISIGYLPDSVHGLVSQIKSFEVLAAKAA
                     VYGDYESALLALCINPLIPSDDLAKTILDEMLEAHKDYLPRFNR"
     gene            6906..7637
                     /gene="chbG"
                     /locus_tag="KR257_000007"
     CDS             6906..7637
                     /gene="chbG"
                     /locus_tag="KR257_000007"
                     /EC_number="3.5.1.105"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003439691.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="chitin disaccharide deacetylase"
                     /protein_id="HBH0028739.1"
                     /translation="MTKIIINADDFGYCEAVNYGIISAHNNGIVRSTSMMANMPGVEH
                     GVGLLKENKTLNCGVHMTLSCGRPLLSNLKTIVDKDGFFIRRITDEIIEKMDCDEIYR
                     ELCAQIDRVKGLGIDISHLDSHHHIHTLVSLKPVIEKIVTKYNLPIRGGFEYNLEYSK
                     VVPLIDSFYKENVSEEYFIKNIDEIMKYDVVDIMSHPAFLDDYILNSTSYAIDRTKEH
                     KILTSKKVKEFLEKNGLVISSYRDI"
     gene            7650..7967
                     /locus_tag="KR257_000008"
     CDS             7650..7967
                     /locus_tag="KR257_000008"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435715.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS lactose/cellobiose transporter subunit IIA"
                     /protein_id="HBH0028740.1"
                     /translation="MDEKMIEISFGIIGFAGDAKGLAFEAIKEAKSGNIDKARECIEK
                     SKESIHKAHKFQTELIQNEANGNKTEISVILIHAQDHLMTAMNFQQLAEEFIDVYERL
                     ESK"
     gene            complement(8079..8543)
                     /locus_tag="KR257_000009"
     CDS             complement(8079..8543)
                     /locus_tag="KR257_000009"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016208838.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0028741.1"
                     /translation="MVHLVYCDNAGKKGEKVLDKILDGTKTMVIRGAAGRKIPHSRVF
                     EDELLYFMEKGTAKISAKATVKKVENYVKLTEDEISKILNENQPKLNLSEKQKVRWHK
                     KCLCLVEFENVEEITPLDFDHQGNMDDWLIVEKIEDVVVGTSIPYNYEKSKF"
     gene            8813..9751
                     /locus_tag="KR257_000010"
     CDS             8813..9751
                     /locus_tag="KR257_000010"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898056.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="HBH0028742.1"
                     /translation="MKKIKSLAIFISIITTLVLVTACSDKNTEDKDKSETRVVQSVKG
                     EVKIPSNPKKIVDISGSSEELLLAGYKPVATANVDSYETDKLPSYIREELKGVKIVGH
                     SMMDTMDMEAILEVNPDLIIMSQRQEKIYDQLKEIAPVVMMKDYANDWRSKLTDVSKL
                     FDKEEEDKSWLQKYDEKATKLGKEVIEKNGEKTYLPVLASSGQFMVFSDGGIGTLIND
                     DMKLARPKNMPKQDGITLPMVSMEGLTDIDADHIVVIATEADKKDLENSAIWAQIRAV
                     KDGNVTILDAAPFFSQSYNPIGKELLLESVKNELTK"
     gene            9879..10892
                     /locus_tag="KR257_000011"
     CDS             9879..10892
                     /locus_tag="KR257_000011"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003439682.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="iron ABC transporter permease"
                     /protein_id="HBH0028743.1"
                     /translation="MTKLSKKNITYLLILVSIVVLVFGIVLSITIGAKDMNLSTVIDS
                     LIKMEDGINMRIVKDVRLPRAIAAALVGGFLAVSGAIMQGITRNPIAEPSVIGITQGA
                     TFAISISLVLQKKLPQLIHGSFSVMMFAFIGASISGLFIYFISSKSRGRVNNVKLALA
                     GVALGTLLISLASAISMYFNLSQQLSFWISGGLVGVKWEGIKLLFVAGGIGFILAIIM
                     APRITILSLGEEVAIGLGQKTKFVRFICIVLVILMTGASVSVSGNIIFIGLIVPQIAK
                     GIVGSDYKYIIPSSLVLGAVLLVYTDILSRMINPPYETPVGSITALIGVPIFIYLVRK
                     GEK"
     gene            10898..11920
                     /locus_tag="KR257_000012"
     CDS             10898..11920
                     /locus_tag="KR257_000012"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003439679.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="iron ABC transporter permease"
                     /protein_id="HBH0028744.1"
                     /translation="MKNIIKINSKTLLVISILMVLIFITFLLSLNMGSFSIEPMDVIK
                     TFLGQGQRNHEIAIFKLRLPRIVIALLVGSVLSTAGVILQGVTKNDLADSGILGINSG
                     AALFVVVYIYLMNGNVYEGMSNLTVFTMPIVALIGALFGAFLIYSLAWKGGINSSRLL
                     LIGIGVNIAFTSILTIFQLKFTTQEFNRVMAWTSGSIWGTSWKYVIAVLPFIVIFMGI
                     TIYKSKYIDVLNLGDEVSISLGVDVEKQRRRLIIYAVILSGVSTAVAGSISFLGLIAP
                     HIGRKIIGPKHKRLIPVSALIGTLLLLIADTISRNLLAPIEIPVGIVVSIIGVPYFIY
                     LMLVND"
     gene            11935..12717
                     /locus_tag="KR257_000013"
     CDS             11935..12717
                     /locus_tag="KR257_000013"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004460318.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBH0028745.1"
                     /translation="MNCINTKNLNVSYGNTDIIKNLNLNIPKGKITTIIGANGCGKST
                     ILKTIGRIISPNSGKIYINGEDIYKKKSKEIAKDMAVLPQSPQAPSGLTVSELISYGR
                     FPHKSGFGNSSKEDREIVNWSLEVTGIAEFKDRNMEDLSGGQRQRAWIAMALAQETDI
                     LLLDEPTTYLDLAHQLEILKLLDELNKKQGRTIVMVIHELNNAARFADHMIGIKKGKI
                     VCEGDAYDVMTKDNLKELFNIDAEIATDPRTNKPICITYDMV"
     gene            12729..14069
                     /locus_tag="KR257_000014"
     CDS             12729..14069
                     /locus_tag="KR257_000014"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003439673.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MATE family efflux transporter"
                     /protein_id="HBH0028746.1"
                     /translation="MENQEALRHEKIWILLFRYSIPAIIAMMVTSLYNVVDRAFIGSM
                     EGIGSIAIAGLGVTMPVFTLIIAFGMLVSVGASTRLSIKLGERNREEAEKILGNALTL
                     SIIISLIITILGLVFLEEILFILGASKDSIFYAKDYMSVILVGSIFNLVAFSLNNAIR
                     AEGNPKLAARTMIVGCVLNLILDPIFIFVFNLGIKGAAIATVLCQIVVFFWVIHYFIR
                     GKSNLKLKKCNLKLNKDIVKKVFAIGMTPFAMEVAISITHMFTNNSLKVYGGDLAIGA
                     MTALTSILLMFMMPVFGLNQGMQTIISYNYGAKQYERAKKTLILSIIVSVVILSFGFL
                     VVQVFPEVFVGIFNKDSDLMDIAVRGISLNLITLPIMGISIVGPVYFQCISKVKHSMF
                     LTLLRQFILFIPLIIVLPIQFNLDGVWLAQPVADFIAMIIVLLFLKREFKTSRV"
     gene            complement(14164..16443)
                     /locus_tag="KR257_000015"
     CDS             complement(14164..16443)
                     /locus_tag="KR257_000015"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003439637.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GGDEF domain-containing protein"
                     /protein_id="HBH0028747.1"
                     /translation="MNFENTKNKKIIATLLLTLLLIVSLTCVTFIMNLNKVTHNETER
                     YLVEVSQGISTTINVKCKSIFRTLYSMGDTYFEINDSEKEVNRYLSKKLKLFEFDWLG
                     IIDSNGNFVSALKDTGNVKGQDFYRKALQGKETITPVKSQSGTYGILYSVPLYNGDKI
                     VGAVAAWNTIDTMRNLLSVESFHGEGFSQIIDQDGNFIVSSANKNAPKNVVNFFDMIK
                     HQGKQVDKNKLEEMKINLKKNKTGSMYYTLNDGISKAMHYLPLQEENLYLLSIVPTKT
                     ASAQFDLLLKKAIFINILIVILFLLLIILIMFINQKNRAQLIKIAYVDSVTKGYSKAR
                     FDIEAKKIIQSSSSESYSLVSINIQKFKLINDSFGSEAGDKTLKYIHDVISNYLEPGE
                     LLCRVSNDQFNVLIKTIPQKEILKYIENITNDINSFNKNEECKYFIALSIGVYKIDDP
                     NLPLVSIQDRANVARKNNKGNIGNHPLYTCVFYSDLERLKMIKEKEMENRMEEALNNN
                     EFIVYLQPKISLKDNTIVGAEALVRWQDPNKGLIPPDEFIPFFEKNGFITKLDHYVFE
                     KVCSMIRKWIDNGETPIPVSVNFSRANLNNIDFLEKYRMLRNKYNIPAKLLEIELTET
                     LVFENLQKLINIIDQIHEEGFQCSLDDFGSGYSSLNMLKEIKVDTLKLDRAFFSSPNA
                     DNIAENHVIESIVNLAKKLNMNSISEGVETILQMDYLKKINCDMIQGYVFSKPLPQEI
                     FEKMTFGKKLEETSMDSSV"
     gene            complement(16780..17943)
                     /locus_tag="KR257_000016"
     CDS             complement(16780..17943)
                     /locus_tag="KR257_000016"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898047.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="UxaA family hydrolase"
                     /protein_id="HBH0028748.1"
                     /translation="MKLMGYLRENGQFGIRNHVLIIPTSVCSSETATRIASLVPGAIA
                     IPHQHGCCQIGSDIELTAKTLIGFGKNPNVAAVLVVGLGCDGIQAKELASEIATTGKK
                     VDYVVIQECGGTLKTVSKGAEIVSKMAREVSKEVRVEFGMSEITLALECGGSDPTSGI
                     ASNPSIGVASNLLVDEGGSSILSETTEVIGAEHLLATRFEDEEMKDKFLKFVSDVEKR
                     AIAMGEDLRSGQPTPGNKTGGLSTIEEKSLGCMYKAGNKPFKGALEYADIVPPDKKGL
                     YFMDTPGQDIDSITGMVAGGAQIVIFSTGRGTPTGSPISPVIKITGNSDTYNKMPDNI
                     DINAGRIITDGAKIADIGQEIFNEIIEVCNGKHTKAESLGHREFGIYRISSTF"
     gene            complement(17956..18231)
                     /locus_tag="KR257_000017"
     CDS             complement(17956..18231)
                     /locus_tag="KR257_000017"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426740.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="UxaA family hydrolase"
                     /protein_id="HBH0028749.1"
                     /translation="MNAIIHANEKDNLVTCVRPLVKGEKVSIDGKSYIVNDNIPVFHK
                     MATEDVKKGDVVYKYGEIIGIATVDIKTGDYVHVHNIESTRGRGDKK"
     gene            complement(18252..19226)
                     /locus_tag="KR257_000018"
     CDS             complement(18252..19226)
                     /locus_tag="KR257_000018"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426739.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="2-keto-3-deoxygluconate permease"
                     /protein_id="HBH0028750.1"
                     /translation="MHILKSVKKIPGGLMVCPLLLGALFNTVCPQALEIGGFTTSLFK
                     TGAMSILALFCLCNGAQINIRQAGKPLTKGIVLTATKFIIGAVLGIIVSKFIGPKGII
                     GITPLAIVATMTNSNGGLFAALAGEYGDSTDVGAISILSLNDGPFFTMLAFGVTGLAN
                     VPIIALFAALIPILLGFILGNLDEDIREFLAPGTTLLIPFFAFPLGAALNFNQIITAG
                     LPGVVLGLGVTIITGMGGYFVMKLIRAEHPAVGAATGTTAGNAAGTPEALAAIDPTLA
                     TIAAVSTVQVAAAIIVTAICCPMLVSYLDKREKKKKSIFKTNKNIEVN"
     gene            complement(19497..21410)
                     /locus_tag="KR257_000019"
     CDS             complement(19497..21410)
                     /locus_tag="KR257_000019"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003439629.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sigma 54-interacting transcriptional regulator"
                     /protein_id="HBH0028751.1"
                     /translation="MKYGGIIMKEILVIAPTKGTYEKSIHIVKKNKYTNIDVVFGNLK
                     EGIPLAEKSINHGTRIIISRGGTYNMLKATYNIPIVEIKVDAYDIIKSYKEVKNSNEP
                     FGIIGFNNVIYGFDIIEEILNKKITMIEIEKEEEIYDAIEKYRKKGINTYIGDTTVAH
                     IVKRLNCKGILIESREENILRAIQQAEQILEATKDEQKRRLQIEAMTDFVHDGIITVD
                     KNFKITLFNKSAEKIFGIKKENALYHNVVDVIPNTVLPQVVETMEPQIGEIQNIGSTK
                     IITNRVPIIVDGQIQGAVSTFQDSKEISSFEHTIRRSLLSKGLSAKYTFDDIIHASEK
                     TKDCIELAKKYACYDTPMIITGESGVGKELFCQSIHNYSKRKNAPFVAVNCAAIPPSL
                     IESEFFGYEEGSFTGARKKGKAGVFELAHEGTIFLDEISEIPLELQGRLLRVLQEKQV
                     MRIGGDKVIPIDVKIICASNKDLKNMMRNGLFRQDLYFRINILTLYLPSLKERKEDII
                     KLSEFFIHKYSSKYNKTPLIITPNIKKALLEREYEGNIRELEGMMERAVIVESFDSIL
                     LEKVSNEYTNNIVDKDNSDFECSNLDLKTLEKKYIYKIYNENNRNTTKTCEILKITRS
                     TLWRKLKEIEDDV"
     gene            complement(21587..22801)
                     /locus_tag="KR257_000020"
     CDS             complement(21587..22801)
                     /locus_tag="KR257_000020"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861720.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="FAD-binding oxidoreductase"
                     /protein_id="HBH0028752.1"
                     /translation="MNQEYVKGNPIFTNINKVPRQFPYLTDDIDTDVIIVGGGVTGCI
                     CAYYLAKNNIKSVILEKGRIAHGSTSVTTSLLQYELDDNLIDLTEVMTLKDALKAYNL
                     CTSALEELDTFIELYGNKCDYAKRDTLLYTANKLEVKAIKEEYNLRKENGFDVEYIDE
                     STNPFNFDLKSGLIAKNGGRELDPYKYSHHLIDVSLKNGLQVYENTEVKKVDLSNDKV
                     TAEVSYGYKVHGKKLIVATGYNTSLFTKRNFATKSNTFNIATKPLKNIASWKNNILIR
                     DNCDPYNYLRTTKDNRLIIGGEDVSFDDIENETLANEKYDILEQRLKSMFKDIKDIEV
                     EYKYCGCFASTLDNLGFIGPDNKNNNLWYCLGYGANGILFAILGGIMLSELYLGKQNK
                     NMKLFKVDRFDK"
     gene            23045..24427
                     /locus_tag="KR257_000021"
     CDS             23045..24427
                     /locus_tag="KR257_000021"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011967718.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TldD/PmbA family protein"
                     /protein_id="HBH0028753.1"
                     /translation="MLSKNIASKVLEKCLITGGDFAEIFEEDTINNSISLIDNKVENA
                     IGGRNYGIGIRIFKGLKSIYAYTSDNSLNSLLDVAYKAAVALGKLEDGKSVILNDSIK
                     INNIHNIKIYPNSIGNKDKVSVMKVAYKSAKEFSNDISQVSVSYLDKDQKILIANTEG
                     IYVEDRRIRTRLGISSIASKGNENQTGFEGPGGCKGFEIFEEIDPEYYAKESARVAHT
                     MLHAKNCPAGNMMVAIDNGFGGVIFHEACGHSLEATSVAKGNSVFADKLGQQIASTKI
                     TAIDDGTIPNYWGSMNIDDEGNPTQKNILIENGILKSYMIDKLNGRRMGMNPTGSSRR
                     QNYKFAPTSRMTNTYIAAGEDRPEDIIKSIPDGLYAKKMGGGSVNPVTGEFNFAVSEG
                     YLIKNGEIQEPVRGASLIGKGSDILMNIDMVGNNVKQAQGMCGSSSGSIPTNVGQPMI
                     RVKEITVGGR"
     gene            24439..25788
                     /locus_tag="KR257_000022"
     CDS             24439..25788
                     /locus_tag="KR257_000022"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728957.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TldD/PmbA family protein"
                     /protein_id="HBH0028754.1"
                     /translation="MELKNFKDILFKKALSEGFEEYEIYYYTGENLSINIYEGEVEKY
                     NLDKSFGLSFRGKVNGKIGYSYTEILDDKAVDMLIKNVKDGVNTIENEDVQFIYEGDK
                     HYNDVKTYSKELENLEADKLIDLALEMERETKAYSDKVVNLSKCTISYSVSSNGISNT
                     KGLNLSNKTNMLIGFVVPIIEDNGQKYDGIGYNIANSIEEIKPCEIAKLGVDNALSKV
                     GGKSIPSGKYKTILLNEAMVSLLSTFSGIFNADSAQKGLSLLKNREGDMIASPIVTIV
                     DDPLLENGMASTPFDDEGVATFKKEVVLNGKLITLLHNLKTANKAGVKTTGNGIKSSY
                     SSPISIYPTNFYIEKGDKSLDEIIKDIDEGLMVTSFAGLHSGANSVTGDFSLAAKGFY
                     IKEGKKVFPVEQITVAGNYFDLLKDIEAIGEDLEFPMSSIGSPSVVIKELSVAGKDE"
     gene            25938..26471
                     /locus_tag="KR257_000023"
     CDS             25938..26471
                     /locus_tag="KR257_000023"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891170.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="manganese catalase family protein"
                     /protein_id="HBH0028755.1"
                     /translation="MSDAHYDMHKRNGYSSDEPYPEIKVLGPNKYYAELLMDDYAGVS
                     SEFTSVNQYLYHNFDLDETHRELSEMWINISITEMLHMEILAKTIRLLGGNPVYRGST
                     SSCGAYWNGGFVCYGNSICNRLKLDLHLEHVAINNYYKDISLIEDPYIKAILNRIILD
                     EKLHVSLFEKAIEKYCK"
     gene            26555..27364
                     /locus_tag="KR257_000024"
     CDS             26555..27364
                     /locus_tag="KR257_000024"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422725.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha/beta hydrolase"
                     /protein_id="HBH0028756.1"
                     /translation="MYYVYVNDINIAVYDLNPSAKKTVLFIHGWPLGHKIFEYQTNIL
                     PKLGYRTVSIDLRGFGKSDATSGGYTYSQLADDIYKVVHAIGLKDFTLVGFSMGGAIV
                     LRYMSLFNGYGVSKLVLAAAAAPSFVQRPPEFPYGMTREDVNKLIAQACTDRPEMVTD
                     FGEKVFASNPPESFRRWFNDIGFSASGIGTIGTAVSLRDEELFNDLKCVRVPTGIFHG
                     KLDEICPYEFAVFMNEKIEDSILYTFEYSGHAIFYDELKLFNQKFLQFLEE"
     gene            27775..29820
                     /locus_tag="KR257_000025"
     CDS             27775..29820
                     /locus_tag="KR257_000025"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893739.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sigma 54-interacting transcriptional regulator"
                     /protein_id="HBH0028757.1"
                     /translation="MKKHNILFVSTDDKINIDISKQLENIFGEFCNIDNLVYVNRINI
                     ELSSYELVVCSDNDIKEYIHNNIDKNIPIVIVHRTINIENINQIISIENDSDVMVIDA
                     YKESADETAKIIRKLGLIHINLIPYYPGCDKSKCEIGIITGSRNSIPQNIKQIIDIGD
                     KVIDINTVIEIFTKLNISIDKLHIIKEKYNEDTVSGYRYYTTMNKTMKSFLEIIDEGI
                     ASVDKLGKFIYCNKVFSNLVGIDQNEIISNNFMDLFSDKVVKKIFFQEDEVNDEVVNL
                     NNKKLIINKVNVYENNERIKSIISIKNISAIQVLEDKIQNKLQSKGFVSKYTFESVVG
                     ESKIIKEKINIARKIATTDFSVLILGENGTGKEIFAQAIHNESLRKNKPFVAVNLSSL
                     SDTLIESELFGYDEGSFTGAIKGGKMGIFERAHTGTIFLDEIGDISLDVQQRLLRVLQ
                     EKEVMRMGGSKIIPIDVRIIAATNKDLKKKIKEGSFREDLYYRINVLHIEIPRLRERK
                     EDIPLISKYFLDEINSNKCFTEESMQALTLYEWPGNVRELKNLIYYIDTIVEEDRVDY
                     EHLPEQFRFEKNNTLVNENFDSIILDFKQSNFFEESICILTSIETWNNKNILLGRNKL
                     QEILKEKDIVLSVDQIRKRIDKLKSHGLLLSGVKKQGSFITDEGKNFISYVKIKGVI"
     gene            30081..31280
                     /locus_tag="KR257_000026"
     CDS             30081..31280
                     /locus_tag="KR257_000026"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003439602.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptidase"
                     /protein_id="HBH0028758.1"
                     /translation="MKSAYKGYEAYSYLEKGKDISSIEMCKGDKRVKEYLIELDDIQE
                     AKVKSIVDEKIFISLHEHPVLFPEHLERDIFEYNREGKQRCAYEALSRGYYDAIFDNL
                     MDGVCTITSNSGWKWDDILIDLGMRLCDLAHQDFVIKCEKVEDIYRAKSEGKVALIPT
                     LEGAAPIENELDRIDILYGFGIRLMGITYSESNALGSGLKEEKDGGLTNFGKKAVERM
                     NKIGMAIDCSHVGVQTTLDVIEYSKDPIILSHVGARSLWNTKRLTPDEVLIACAKKGG
                     VIGVEAAPHTTITEKNKEHSIESFMEHFEYIKNLVGIDHVAFGPDTVYGDHVKLHSVL
                     AAKFDIKKITGTKEHPKVEYVKGLENPTETSKNIVRYLVKHGYSDEEIEKVLGGNILR
                     VLKQVWK"
     gene            31332..32027
                     /locus_tag="KR257_000027"
     CDS             31332..32027
                     /locus_tag="KR257_000027"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422731.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF5058 family protein"
                     /protein_id="HBH0028759.1"
                     /translation="MDYLKLANHPLLWIASTVAVSIVVVQSLIFAIKSCKVGKTMGIT
                     DKQIKSAVKSSAISAIGPSMTIFAGMVSLIVTMGGPIAWMRLSFIGSVIFESMSAGFG
                     TDALGITLGSPEMTKLAFTNAVWTMILGSLGWIIFTLLFGHKLDKITNVISSGKKSFI
                     PIISLGAMLGSFAYLNADRVLRFDNGTIACISGMAIMVILCMLEKKKNIKWLREWGLT
                     ISMFSGMIIASVI"
     gene            32040..32717
                     /locus_tag="KR257_000028"
     CDS             32040..32717
                     /locus_tag="KR257_000028"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426728.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0028760.1"
                     /translation="MSKVKSIYNEEYLPFKIRYGRLTLSLGIIAALVPGIILSFGFGI
                     MPPISALLASTMAIVSMSAPNYIIEPVSYSPILGIPGTYMSFLSGNISNMRLPCSIAA
                     QKAAEVESGTEEGSIISTIGIAVSILVNISILTIGVILGGSVLSKIPAEVVEKLNLIL
                     PALFGSVFGQVFLQDKKLGLVAIVISVLTIILSKQGIIPQSLVVLICVFGTMLIARAM
                     YKDKLSD"
     gene            32828..34429
                     /locus_tag="KR257_000029"
     CDS             32828..34429
                     /locus_tag="KR257_000029"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003439599.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amidohydrolase family protein"
                     /protein_id="HBH0028761.1"
                     /translation="MIYDLILKNGFIIGGTGNPGFYGDIAIKDNLIAKIDSKINSNTN
                     KEIDCCGKVITPGFIDPHVHEEIVAILDGKFEKFLKQGVTTTINGNCGHSITPYSSEN
                     VYEYMYKNGLLLEEEKKYLIDKNKCWNNFTEYCDLISKSGISVNMGFLLGHGTIRWSV
                     MGGSKDRPPTEKEKNEITDIINDGMKSGAFGISTGLAYIPSKYADIDELVDIAKQIKE
                     HDGIYTSHIRDYIGRYNAVKEAIEVGQKSGARVQVSHLSPVEIEAFDEILKARYNGVE
                     IMVDTVPRSSGHCMKKKRVIQFIMAISSSLFELGINGVMDALRNEEGRTLILKEAFIL
                     GDRGSIILLNTKDINMEKKSIREIATQKGIDEDKLLLDLLLDGDEELIFCLGGMYRAD
                     FPDKLHDDKIIDNPFVMVGSDCLFSVGGDMSWFELQRRGAFPIFFNMYRKSGVRLEEI
                     VRRVTSLPARQFKIKNRGILKEGLIADIAVIDMDNYSYSRSEDIDFSKPQLLANGVEY
                     VIVNGKIALENGEITENKCGEVLKR"
     gene            34878..36167
                     /locus_tag="KR257_000030"
     CDS             34878..36167
                     /locus_tag="KR257_000030"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898029.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HlyC/CorC family transporter"
                     /protein_id="HBH0028762.1"
                     /translation="MRELLKVTLIVMLVLINAFFVACEFAMVKLRSSRIDTMITEGNN
                     NAKRCKIIKDNLNSYLSACQLGITLCSLALGWMGESTVKELILPIVSVFNLSESIIYT
                     ISISISFLIITMMEVVIGELVPKALALYNTEKIMLSTSFLLVGFYKLTYPIIYFFNLS
                     TDLFLKPFGYSQADEVDEPHTGDEIRLLVEESYKSGLIDESEQRLVDNIFEFEEKKIR
                     EIMVPRTDMVCIYESDSEEKILAILKEEGVTRYPVCRKNKDDILGFVHIRDLYNQKIN
                     ENKIELEEILRDIIYISENLTIDKALERIRKEKLQLAIVVDEYGGTSGVVTIEDILEE
                     IVGEIQDEFDKEETHIKKIGAGSYLVDGTESINYINKYFGLDIEHDGFDSIGGWISYM
                     LGSNIKVNQSVTFENYNFTILELDKLRVVKLIIKSVI"
     gene            36196..36876
                     /locus_tag="KR257_000031"
     CDS             36196..36876
                     /locus_tag="KR257_000031"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898027.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HAD family phosphatase"
                     /protein_id="HBH0028763.1"
                     /translation="MQKVEGIIFDMDGVLFDSERISLEFWMETFEKYGYTMTKEIYTS
                     VMGRNRKGIIEGLTDIYDSSVPIIDLYDEKTKNMIEFMERKGAPIKLGVNELISFLKE
                     NGYKMAVATSTKRERAVKRLAKANLKDYFDAIVCGDDVVNSKPNPEIFLKAAKKINVN
                     PKNCIVIEDSPMGVEAAYNGGIRCINVPDLKEPDEQIKSQSHKILENLLEVREYLKSL
                     NSKECHNL"
     gene            36977..37516
                     /locus_tag="KR257_000032"
     CDS             36977..37516
                     /locus_tag="KR257_000032"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891160.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="putative ABC transporter permease"
                     /protein_id="HBH0028764.1"
                     /translation="MDNVGSLLYFLFNFFLYGFIGWIIENLYSYYKQGHFQEDGFLNG
                     PFKPMYAIAMSIIIEVSRFIDPNNIFALLLLCLVVPTVVEYITGILMKVYFNKVYWDY
                     SDYKYNSRGIVCLKFSVYWTILTFIGVRYFQVYIVDSLYSLIIPYWPIVVTILLVTLF
                     VDEILTIKFLRGNKDIVER"
     gene            37692..38711
                     /locus_tag="KR257_000033"
     CDS             37692..38711
                     /locus_tag="KR257_000033"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422742.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Gfo/Idh/MocA family oxidoreductase"
                     /protein_id="HBH0028765.1"
                     /translation="MMGKIRFGIVGTSNIANIFLRAASRVKDFELVAVYSRNLEKARE
                     FGTLYGASIFFDDLEQMAKSKDIDAVYIASPNALHSKQTITCLKHKKHVLCEKSLASN
                     LKEVKSMIKTAKDNNVLLMEAMRITCVPNFKAVKENLYKIGKIRRFFGSYCQYSSRYD
                     KYKNGIIENAFKKELSNGALMDIGVYCIHPMVNLFGAPKTVKAVSHILQTGVDGEGSA
                     VFQYDDMDAIIQYSKVADSYIPSEIQGEEGSIIIEKLNLFEKAIIKYRDGREEDISIP
                     KEKAEEKPREIEGMYYELVEFISLINNNKIESNINSHENSIIVMEIMDEIRRQSSIVY
                     PADSI"
     gene            38999..40189
                     /gene="dltD"
                     /locus_tag="KR257_000034"
     CDS             38999..40189
                     /gene="dltD"
                     /locus_tag="KR257_000034"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426716.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="D-alanyl-lipoteichoic acid biosynthesis protein
                     DltD"
                     /protein_id="HBH0028766.1"
                     /translation="MRKLIYFITPFIIGVVFLFGLDKFLDSKTDELLREKNLLPIMDD
                     TLSDIKDKGVTANNHFLREKDIMILGSSELSNSTKQHPKYYFNTNRSKNKVFAIGRAY
                     TQTLQDAAILGSMNPNIDNKKVVLLISMQWFMEKDGVTSHHYQSRFSPIQFYRFLDNP
                     KISKQNKIEYAKKSSKLLWGSDEYKAEALYAKLYEPKTFPEKAEKVLLEPYFQGRKYC
                     IALKEKGILYKRLIKLDKKRATKRKRPINWSYERKKAIEDAKKRVGKNPLNIDKYYYK
                     EHFKDGIEQYKGRDKDVNLLTSKEFENYKLMLNVCTDLGIKPVVVLIPSMDKFYNLTG
                     ISEKERNQYYDKAQKIAESKGFEVLNLKDKGSDKYYLRDVMHLGTKGWVDVCERLFKI
                     FKEQ"
     gene            40310..41824
                     /locus_tag="KR257_000035"
     CDS             40310..41824
                     /locus_tag="KR257_000035"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893738.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="D-alanine--poly(phosphoribitol) ligase"
                     /protein_id="HBH0028767.1"
                     /translation="MKIIEGIKKYSNTDRTALMCNGDKLSYKDLNEYSDAISVFLKDV
                     YKEEDTPIVIYGNKENMIMACMIGALKSGRAYVPLDISFPIDRVFEVTKEIKPKVLFN
                     FSDERNFGDINVIDMDKLNYIINEYQGKSLDKENWVKDDENAYILFTSGSTGKPKGVQ
                     ISSNNLDSFSDWISPYLNIDGSEKVIMNQPAYSFDLSVTTIYPGLIHGATLFSISKDV
                     LADYKELFRQFSISDIAVWVSTPSFAGVCITEKEFNSKMLPNLESMIFIGEALSKNLT
                     KELMSRFPNTRIINGYGPTEATVGVSVNDMTQKAIDDEKSLPVGYPMSNCKIKILDED
                     GNELKENEKGEIIIIGPSVSKGYFNNKEKTDEVFFYDEIDGVKWRAYKTGDMGYLLDG
                     NIYYCGRKDFQIKLNGFRIEIEDIENNLRKVHNVKNAVVLPVYKDEKIAYLKGIVELN
                     EKNDLSNIKNGMIIKKELGKYIPSYMIPRNISIISEFPTNINGKIDRKKLMEEI"
     gene            41824..42972
                     /gene="dltB"
                     /locus_tag="KR257_000036"
     CDS             41824..42972
                     /gene="dltB"
                     /locus_tag="KR257_000036"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728953.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="D-alanyl-lipoteichoic acid biosynthesis protein
                     DltB"
                     /protein_id="HBH0028768.1"
                     /translation="MIFSQYGDYFYLYILLLTSIPAVILGLMGKNIKYYGMLASLFMI
                     FLIVGIDVQLKYLVIFIILEVIIVKGYEYVRRKTKNKYIYWGFLFASMLPIIINKISP
                     VTSFGIIGFIGISYLNFRTIQMVIEIYDGAIKEVKISKMLYFMLFFPTLSSGPIDRSR
                     RFEQDLEKQISRKEYIEEYLLPGIKNIVMGVGYKFVIAFLINTYWVSRIPKDMSFINI
                     LSYMYAYSLYLFFDFAGYSLFAIGTGYIFGIQVPINFDKPFISKDMKEFWTRWHISLS
                     RWFGDYIFSRFVMSSMRKKRFKKRTTAAHVAQMITMITMGFWHGLTWYYVAYGVYQGL
                     ALVLTDIYQRKSKFYKKHKKDKWFERVQIFITFHIVCFGLLIFSGYLA"
     gene            42991..43221
                     /gene="dltC"
                     /locus_tag="KR257_000037"
     CDS             42991..43221
                     /gene="dltC"
                     /locus_tag="KR257_000037"
                     /EC_number="6.1.1.13"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861715.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="D-alanine--poly(phosphoribitol) ligase subunit
                     DltC"
                     /protein_id="HBH0028769.1"
                     /translation="MQETVIEIFEDVLGTDEIREDLDLNLFETELLDSLAIIEVLLEI
                     ENRLGIELQPTDLERKDMSTVNNLVKFLETRK"
     gene            43438..44223
                     /locus_tag="KR257_000038"
     CDS             43438..44223
                     /locus_tag="KR257_000038"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003439571.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DeoR/GlpR transcriptional regulator"
                     /protein_id="HBH0028770.1"
                     /translation="MSLNSIDRKKEILKLLDSKGKVNTKELVKRLEVSSETIRRYLEE
                     LENENKLKKVYGGAIKINYGVIEPEHIKRNNTNLDKKQSIAKYAAKFVNDNESIIIDE
                     GTTNLQIVDYIISVNNLKIITNSYPVLSKLISYENQGLFDGEVIFIGGKVNLKHQRTA
                     CPISIDAMKNLYVDKAFISSEGILDSFGISSIDQNKALLSKAYIKNSKESFVLCDSSK
                     IGIASMYKIADLEELDFVICDVEPPNEWKDKLNEINITWIEAK"
     gene            44502..46412
                     /gene="phnW"
                     /locus_tag="KR257_000039"
     CDS             44502..46412
                     /gene="phnW"
                     /locus_tag="KR257_000039"
                     /EC_number="2.6.1.37"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891151.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="2-aminoethylphosphonate--pyruvate transaminase"
                     /protein_id="HBH0028771.1"
                     /translation="MKKIYGEKIKAVVFDWAGTTVDYGCFAPLNVFIEIFKRRGIDVT
                     MEEARKPMGKLKIDHIREMCEMDRIKNIWSDKFGKVPTEDDVNELYAEFEPMLFETLE
                     EYTTPIPHVVETIEKLRKNGLKIGSTTGYTREMMNIVEPNAAKKGYSPDFLVTPSEVS
                     QGRPYPWMCYKNAEALGVSPMSSMVKVGDTISDVKEGVNAGMWSVAVIKGSSELGLTQ
                     EEVENMDKEELKAKMSIVSKKFKEAGAHFVIETMAELEDILIKIENETIKSDFVPEND
                     YILLTPGPLSTTKSVRASMLKDWCTWDVEYNNLVQDVRRRLVSLATQNTDKYTSVLMQ
                     GSGTFSVEAIIGSTISKDGKLLVIANGAYGKRMKDICNYLNIQFVDCTFKDIEAVDLN
                     VVENLLKENKDITHISMVHCETTTGRLNPIQEVGKLAKEYNKIYIVDAMSSFGGIEID
                     VEDFNIDFLVSSSNKCIQGVPGFGFIIANKEKLSKCKGIAKSLSLDVYAQWETMEKNN
                     GKWRFTSPTHVVRAFYQALLELEEEGSVEKRYARYKENQFTIASRLKSLGFDTLVNDN
                     AQSPVITTFLYPKNAKFEFMEFYTYLKDNGFVIYPGKLTDIDTFRIGSIGEVYPTDME
                     RLADVIEKFINR"
     gene            46771..47592
                     /locus_tag="KR257_000040"
     CDS             46771..47592
                     /locus_tag="KR257_000040"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426706.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0028772.1"
                     /translation="MNEELSSLRFDGVGKCKGGIFDNVNISGTGKIEGSVKCSKFDSS
                     GSAKVFGTTECNEFFTSGLSKVEGNILASKVEISGLLRCTGNINSVEIDTSGIINVEG
                     SIKSDIIHGEGYLKANENIDCENINLSGILECNGFLNCEEVNISLNGTSNFNEVGASS
                     INIKKGHGDYCKKFRMLEKKHINFEKVSSNLISLGLLSIRKYTESKLFANIIEADEIS
                     LENSEVKVVRGKNIKIGKGCYVESLEYSESIEIDEDSIVGEIKNISEKIKLKKDK"
     gene            47633..48400
                     /locus_tag="KR257_000041"
     CDS             47633..48400
                     /locus_tag="KR257_000041"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893737.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="polymer-forming cytoskeletal protein"
                     /protein_id="HBH0028773.1"
                     /translation="MEKGSIKILGEGFISSGEYENIKIVGSSKSKGNVKSNEVKVLGD
                     AKFEGDINIKNFVVNGKTIIRGNLKAERVRVNGQLNIEGDAEIDDLVITAQQKVDGKL
                     KCNNVTIRGQLSVNENMYAQDIKIYGEMRNKSNIECEDIKVYGAIKCDGLLNGENIYV
                     YSGGGSYCKEIGATNIKIGRSKDAFSLIKIINIFSGKFKCNLIEGDTIELEDASIKDI
                     RGKSISLVDNCDVGNIEYSDNLSVSDNSTVKNSIKVG"
     gene            48408..49028
                     /locus_tag="KR257_000042"
     CDS             48408..49028
                     /locus_tag="KR257_000042"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861712.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YhbD family protein"
                     /protein_id="HBH0028774.1"
                     /translation="MEELISKKDLLSKTNISYGQLYRWKRKNIIPEEWFIKKSAFTGQ
                     ETFFPRDKILERIELILSMKEETSLDDIANMFMKKDINKEFDIDFILSKEVICNYTKE
                     IFQNLYKKEQSIGKKELLILSIIEKFLVKSIITFEELKLIVNIIEENFTSIYNESGKI
                     YLFRKFGVPFVVGCLDYKKVKFEKDVVKIIEIDLTKEINDISIKLS"
     gene            complement(49328..49915)
                     /locus_tag="KR257_000043"
     CDS             complement(49328..49915)
                     /locus_tag="KR257_000043"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426696.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="rubrerythrin family protein"
                     /protein_id="HBH0028775.1"
                     /translation="MNLKDSKTKENLLRAFAGESQARNRYNISASVAKKEGLYIIESL
                     FNYTADQEKSHAKQFFSKLKEFAGENISISGAYPVDLYDKTAQHLKAAQHNELQEWDD
                     VYKNFGKTAREEGFESIAKLFENIAEIEKVHGDRFGRYATDLEEGTLFRRNEDIQWIC
                     THCGHIHIGKEAPKACPVCLHPQGYFLDFKNSLFE"
     gene            complement(50001..50438)
                     /locus_tag="KR257_000044"
     CDS             complement(50001..50438)
                     /locus_tag="KR257_000044"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436793.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MarR family transcriptional regulator"
                     /protein_id="HBH0028776.1"
                     /translation="MEDKYIVHFISKTKASMIKFIENKLSKNGLGELIPTHGNILTAL
                     YENNGILTMKEIAAKIGKDKSTVTVLVNKLINLGYLERQKCTNDKRITYIKLTKKALL
                     IEDTFNSISTQVKETAYHNITENEKQEFLRILKKINDNFKNAD"
     gene            50542..51540
                     /locus_tag="KR257_000045"
     CDS             50542..51540
                     /locus_tag="KR257_000045"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891143.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YhdH/YhfP family quinone oxidoreductase"
                     /protein_id="HBH0028777.1"
                     /translation="MNKKFKSLYITEEEGNFRRNIVEREVDTLPEGEVLIKVKYSSLN
                     YKDALSANGNKGVTRKYPHTPGIDASGIVESSSCDDFKIGEEVLVTGYDLGMNTSGGF
                     SEYIRVPSSWVVKLPKNLSLKEAMDYGTAGFTAALSVYKFIDSVDKNMGDVLVTGGTG
                     GVAVIATKILIKLGYSVVVSTGKLEEQKEVLLNLGVKDVIHRSEVDDNSGRPLLRPRW
                     AGVIDTVGGNTLATAIKTTNYCGAVTTCGNAGGVDFTSSVYPFILKGITLYGIDSVDC
                     PMNLRLKIWDLLSNEWKLDDLDDMVNVVSLEELNDSIDSIMAGKHVGRTVVDLEKI"
     gene            complement(51660..52586)
                     /locus_tag="KR257_000046"
     CDS             complement(51660..52586)
                     /locus_tag="KR257_000046"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436788.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="carbon-nitrogen hydrolase family protein"
                     /protein_id="HBH0028778.1"
                     /translation="MSKENKNVRIAVVQASPVIMDLEKTVEKALGLIKEAGRKGANIV
                     VFPEAFIPAYPRGLSFGFVVGSRTMEGREDWKRYYDNSVPVPSATTDLLGKAAQEAGV
                     YLSMGITERDGNDINCTLYCTNLFFSPEGKLIGKHRKLKPTGTERCIWGEGDGSTLTV
                     VDTPYGKMGSLICWENYMPLARTALYAKGVKLYIAPTADSREEWQATMKHIALEGRCF
                     VIGCNQYVEKNTYPTDLNYYKELDAEPEIMCPGGSCIVDPFGKYVAGPIFNKEEMLIA
                     DLDLEKIVLSRLDFDSEGHYSRPDVFELIVHE"
     gene            52972..54576
                     /locus_tag="KR257_000047"
     CDS             52972..54576
                     /locus_tag="KR257_000047"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898010.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amidohydrolase"
                     /protein_id="HBH0028779.1"
                     /translation="MKAKIYYNGNIITMEDSICGDAILIKDKIIKKIGTKEEVFALKN
                     KDTEIIDLQGKTLMPSFIDSHSHLIAFATTLKLVPLEDATSFKDIVKKIQDFKESNNI
                     KKGDWIIGFSYDNNFLEENKHPDKSVLDSASSENPILISHASGHMGVANTLGLKQLGV
                     TNETRDPEGGHIGRVEGSEEPNGYLEENAFFNVASKIKQPSSNEIFNSIEKAQNIYLS
                     YGITTAQEGLMEENQFNILKAMANQNKLKMDVVGYVNLKKSKSVADNNREFIKKYINR
                     FKIGGYKIFLDGSPQGKTAWLSRPYENSDDGYCGYPIYKDEEVEKFIDISLKEKMQLL
                     THCNGDAAADQLIDAFEKVLNLKEQSSENNIRPVMIHAQTVRADQIDDMKVINMIPSY
                     FVAHTYYWGDIHIKNLGEDRAFKISPLKTTIEKGLIYTLHQDTPVIAPNMLETVWCAV
                     NRITKKGIQIGENEKISPLDALKGVTINAAYQYFEEDKKGSIKEGKLANLIILDENPL
                     TIDPMKIKDIKVLQTIREGEVLYSLK"
     gene            55392..56663
                     /gene="serS"
                     /locus_tag="KR257_000048"
     CDS             55392..56663
                     /gene="serS"
                     /locus_tag="KR257_000048"
                     /EC_number="6.1.1.11"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000884181.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="serine--tRNA ligase"
                     /protein_id="HBH0028780.1"
                     /translation="MLDIKRIRENLDCIKKAMERRGEKNFNLDEVVKLDDERRKTLQE
                     VEVMKNELNTASKNIPNLIKEGKDVENEKIKLKELSDKIKVIDQNLKEVEDKMEYLLM
                     RIPNVPHPEVPQGETDEDNVEVRTWGKTTTFDFESKAHWEIGTELGILDFETASKITG
                     SRFTLYKGLGARLERALLNFYLDTNTKVNGYTEVIPPFMANRNSFLGTGQLPKFEEDM
                     FKIEGMDYFMIPTSEVPLTNIHANEILKFEQLPINYTAYTPCFRSEAGSAGRDTRGLV
                     RQHQFNKVEMVKIVAPEESYNELEKLTNNAETMLQLLNLPYRVVKICTGDLGFTASFK
                     YDVEVWMPSYNRYVEISSCSNCEDFQARRAGIRFKRDKDSKAEYVHTLNGSGLAIGRS
                     VAAILENYQQEDGSVVVPEVLRPYMGVSVIK"
     gene            57031..58536
                     /locus_tag="KR257_000049"
     CDS             57031..58536
                     /locus_tag="KR257_000049"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422776.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="histidine kinase"
                     /protein_id="HBH0028781.1"
                     /translation="MKIQNTEWGYIEWKHTYDENNPKQAMNIYIAVTMPGKKHFNHVH
                     YGQEQMIYILEGEGLYIINGVWKPFYQGMIFYIESGSTHETINTGDREIKELIVSNNV
                     DDVGESEVIDINPNNYLKKTLINYSESTLNLYAAVESIRGQFIDPFKIPLIIYDDSWN
                     IVLKNPYFPLFCFEKCNPMKFPQNCDCMNQKSSNQFVCEYGITIYNIPILYKSNSIGV
                     IRGGYVLLSDLNLDTEHNNLYDIPEGAARSIKRLLKQISKNIINFCSFNDIRKDLQEK
                     EKTIARTYHYGEQLEMNLKVAQDMVTNLRINHHFLFNTLNSMASIALDDGSYDLYSAI
                     IDLSRMFRYTMRSDLRFVELESEILYIKNYLNLQKLRYGDALKVKYLIPEKLYNLSVP
                     FNFIQPIVENAFTHGFRDIDTEKRIEIIARLDSQYAIIEIHNNGTILDGNNIDKIKAG
                     IRSNNGHGLSLIYTKFTSAYGNNFDMDIKSSDNEGTYIMIKIPIENYKEYV"
     gene            58650..59348
                     /locus_tag="KR257_000050"
     CDS             58650..59348
                     /locus_tag="KR257_000050"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436119.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator"
                     /protein_id="HBH0028782.1"
                     /translation="MRRALIIDDEEAVLKIITHFIEMKDMPIKIVGKATSGDEAVDKI
                     IGLEPDIVFIDIQMPIYNGLEVIEKTSHLSKKINFVVITAFNYFEYAQKALRLNVKDI
                     LLKPLDMKEFTKSVEKIIGYQYTNNDLLNEILEYINLNYSNDLKLNDCARLFLTNPSN
                     ISRIFKSNLNTTFISYLNHIRIEKSIELLENTTKSINEIAEIVGYNSLNNFYKNFKIE
                     KGMTPKVYKLNTKN"
     gene            59633..60721
                     /locus_tag="KR257_000051"
     CDS             59633..60721
                     /locus_tag="KR257_000051"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436120.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0028783.1"
                     /translation="MSDKVNMKNIICIAGAYLATAIGSGFATGQEILQFFASQGYMGL
                     IGALISMVLFSFLGAEVITRGRELKLKEPTRIYTFYCGKILGKFYEWFSPIFLFGILI
                     VMISGAGSTLTEYYGINPYLGRVLMAVATLITVSMGLEKLVSILGRIGPVIAVFTIAV
                     GLISLFKHFDGLSMVGEAMKNIEVTKASESPIVSGVIYNTLNIIVMIVFLTGMGASIE
                     SKKDAFWGGLLGGIVFMTAGIVMYLAMISDIGNLYMKEIPSLYLADNISPIVGVCFSV
                     ALILGIYTTAVPLLWSVTNRIVEDEHPKFKLVTTVIAILACIGGFLPFGKLVNILYPY
                     TGYMGLLILVCMVYKAITCRKKSTQSQE"
     gene            60960..62150
                     /locus_tag="KR257_000052"
     CDS             60960..62150
                     /locus_tag="KR257_000052"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426680.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amidohydrolase"
                     /protein_id="HBH0028784.1"
                     /translation="MHELILISEKYKEDILDFFTDIHMHPELSFKEFRTTKAIKDLLV
                     SLDIEILDLGMETGVVGLLKGKYDGPTVALRGDIDALPIYEEVDIKYKSRYDGIMHAC
                     GHDIHTSCLVGCAYVLSHIRDSLHGNVKFIFQPAEEVNKGAKMLVERGVMENPKVDAI
                     FGLHNHPDIPCGKIGVKLGGLMAAVDTIKIEVNGFGGHGGIPNRTIDPIVASSAIIMG
                     IQTIVSRNISPLESAVISIGTINGGTANNVISEKVDMTGTCRSFSNEVRKKISENLEN
                     IVCEIARGYQATAKLDYLFDLPAVINSKEMYAIACKSVCDLYSEDAIVDPIPSTGGED
                     FSIFMEKAPGFFYWLGVGNKEQDCIYQWHNPKFKADKNSILVGTNVLCQSVINYMDKL
                     KNKI"
     gene            62241..63743
                     /locus_tag="KR257_000053"
     CDS             62241..63743
                     /locus_tag="KR257_000053"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891132.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AbgT family transporter"
                     /protein_id="HBH0028785.1"
                     /translation="MRALNVVERAGNKLPDPVTIFLLLCIIVVILSAVISNLGVEEIH
                     PSTKEVVKVVNLLEKEQIQSYLGSIVTNFQSFAPLGLVLVTMLGAGVAEKSGFMEVLM
                     KKGISKVPQKLVTVAIVFAGMLSHTAADVGFIILPPLAALVFLGIGRHPLVGMFAAFA
                     GVAGGFAANVMLSTTDVLLAGFTIPAAQMMDPSYQGNPAMNLYFAFISAIVLTFAGAF
                     VTEKFIAPRFTKYNDSTNDKDIQELSELENKGIKYALLSLLVVVVVIVALCIGDNAFM
                     KDPETGSILSSNAPLMKGIVPIITIIFLTPGLVYGKVSKKIKSDKDLVSMMGSSMSDM
                     GGYIVLAFIASQFINLFNLSNLGTILSITGAKLLAESGIPSYGLIIGFILLSGFINLF
                     VGSASAKWAILAPIFVPMFMLLDFNPALTQIAYRIGDASTNPISPLFPYFPVILAFAR
                     RYDKDIGIGTVISNMIPYSVVFTLIEIIILLLFMGIGIPLGPGGGISYVL"
     gene            63815..65071
                     /locus_tag="KR257_000054"
     CDS             63815..65071
                     /locus_tag="KR257_000054"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422786.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="serine hydroxymethyltransferase"
                     /protein_id="HBH0028786.1"
                     /translation="MLKTTKISDPELYKIVADELVRQEHNIEMIASESTAPTEVLELS
                     GCVFTNKTEEGYPGARFQAGSEEADKLETLAIKRAKEVFGAEHVNVQPYSGSTANYCV
                     YSSILKPNDTVLSMRLDQGGHLTHGSAVNFLHDIYKYEFYGVDPNTGRIDYDALEAKA
                     KECRPKLIIAGASSYPRLIDYERISKVAKEVGAYFMVDMAHVAGLVAAKVIPSPVPYA
                     DFVSSSTTKTFCGPRSGIVLCKAEHAKKLDKGVFPGTLGSIHLNTVAAKAFSLLYLST
                     DKFKKIMEQVVVNAQTLASELISHGFSIVSGGTDNHIVMVDLRSKNLTGKQFEKALEY
                     VGITVNKNVIPDDPQSPFVTSGVRIGLTSISQRGLKEKEVIQIAGIMNKVAENIDNKE
                     VLDECKAEAQELISKFPLYPEGYFED"
     gene            65243..68017
                     /locus_tag="KR257_000055"
     CDS             65243..68017
                     /locus_tag="KR257_000055"
                     /EC_number="7.2.2.10"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891126.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="calcium-translocating P-type ATPase, PMCA-type"
                     /protein_id="HBH0028787.1"
                     /translation="MRYYNKPTKEVLKYLKTNPEIGLDDNEVEERKLRYGLNEFTIKE
                     GRTFWDELGESLTEPMILILIGAAVISSFVGELHDALGILGAIFIGISIGIITEGKSK
                     KAAHALSKLTENIEVKVLRNGKIIKISKNDLVPGDIVYIETGDMIPADGRLIQSINLK
                     LREDMLTGESDDVAKNADAVLDMEVVYSKTEIIEQDAIPAKQVNMVFGGTLVAYGRGI
                     MVVTHTGDKTEMGKIAQNLSNEDQQTPLQIKLGKLGAKIAGISGVIATLLCMFMIIQM
                     QRKGMLILDTSSVLSFLQSLEPAKNAYMVCIALIVATVPEGLPTMINITLAITMQKMA
                     KINALVTKKEACETIGSVSVICSDKTGTLTQNKMMVEVAYVDGKYISGGEYQSNSYFE
                     QNCIVNSTADIEKEDNSFKYIGSATECALLLYHNDKNYNEMRKQTYLISQIPFSSEEK
                     KMSTLIRQEDSDILLSKGAPEVLLKKCSYVQQGKNIVPITPKVEKSILDEIKKLQIKS
                     MRTLGFAYKKMSNSKTEVAMTSEGELNLIGNSRSYMKEDNLVFSGFVGIVDPLREGVK
                     DSIDKAFNAGVDVKMLTGDNINTATAIGNELGLLNDGKKAVEATYIDVLTDKELREEI
                     KGISIVARSKPDTKMRIVSALQKSGEVVAVTGDGINDAPALSQADVGIAMGISGTEVS
                     KNAADIILTDDSFSTIVEGIKWGRGIYENFQRFIQFQLTVNIVAFIIAIISQLTGKDM
                     PFTTIQLLWVNIIMDGPPALALGLEPVRDYVLKRKPINRHSGIIARSMFVNIIINAIL
                     IITIVFTQSAFNILGATSEEQGTVIFSLFAFSALFNALNCREFGLNSTIPNFFKNKLA
                     LQIIVVTGIIQIIFTQVFQSFFNSVSLDFDMWIKIILFASTILLSNEFVKLILRTMKN
                     SRTMNFNSKN"
     gene            complement(68118..68267)
                     /locus_tag="KR257_000056"
     CDS             complement(68118..68267)
                     /locus_tag="KR257_000056"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891124.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="proline--tRNA ligase"
                     /protein_id="HBH0028788.1"
                     /translation="MFFISYIYTKSPIEFDTPLQKEAYKILQKLDIDFECVDTDEAIT
                     MEDCV"
     gene            68642..69820
                     /locus_tag="KR257_000057"
     CDS             68642..69820
                     /locus_tag="KR257_000057"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891122.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cation transporter"
                     /protein_id="HBH0028789.1"
                     /translation="MFSKILVKTFIRDSENVQNTDVRNKYGYVAGVVGILSNLLLFVI
                     KVFIGMLTSSIAIMADAFNNLSDMASSAITMIGFKLASKPADKEHPFGHGRIEYLSAL
                     IVAFMVMLVGLQFVKSSIERIVNPIPVKFEVIPLILLIASIMIKIWLSRFNKFMGNKI
                     DSSALKAVSLDALGDVFTSSCVVISFIVARFTNFPIDGYVGIVVSLVILYAGFSLVKD
                     TINPLLGEAPDEEMVNSIIELLLSYKYIIGTHDLIIHNYGVGRCIASIHAEIPSNIDI
                     MEIHEIIDTAEREISEKLDIYLVIHMDPICLEDKEVMSAKKELEEILKKNSLVKSMHD
                     FRIVGKGSKKNLIFDIVVNPSEFSKNMSEDDLKEDITKLVKEINPEYNCVIVVDKDFI
                     "
     regulatory      69947..70032
                     /regulatory_class="riboswitch"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF01786"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="cyclic di-GMP riboswitch class II; Derived by
                     automated computational analysis using gene prediction
                     method: cmsearch."
                     /bound_moiety="cyclic di-GMP"
                     /db_xref="RFAM:RF01786"
     gene            70150..73068
                     /locus_tag="KR257_000058"
     CDS             70150..73068
                     /locus_tag="KR257_000058"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_021362860.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SrtB-anchored collagen-binding adhesin"
                     /protein_id="HBH0028790.1"
                     /translation="MKKGNRKALLISLIMILSMVVSTIYPTVSYASELGENSQIQSGS
                     TNSSTGEEKESDNKKPEQTPEKDKATDNKKPEQTPEEEKPTDNKKPEQTPEEDKSTDN
                     KKPEQTPEGEKPIDNKKPEQIPEEDKSTDNKKSEQALEDEKPLDNKNTEKTPEEDNLL
                     EDENLLKVLEEELNEENEDYGFVVKINNNTIETESMKKISFNLTYTPTSKGIQAGDSI
                     TFKVPDVFNKVNLDYTSECFDKTESNGEYTLTFRELPNGQSVMQGKIGLEAYVKKVDE
                     DTNAKIHIETTGKIESGSGDIDVEIKPGDKTDVPDAKGTLKKLVEGKKSTTVFMPVKN
                     KDINYSIQVNEKQEELKDIILYDELPEGLTLINGSVSVVTSDGKEVSDFNIEQSKNSI
                     SVNFGNIDKSYTVKYKARISDKNAKHGNKYKNVARIESDGKKIQEDDATVSIFDRGDD
                     YLLTKGHSGATNITQVGQVINYQISINDDKSPISNVVITDNIPEGMRLTTSGEAGHDF
                     RVVEIPMNGSWTPWSKEKIANNISYKVEEKRNESGQVDKVITGFTINLSKEEVESKFF
                     IAYTLKVISIEDSYINRAVLDANNSEIDKNDEINFKKNSGLISAKKEVDKKVLNSSDN
                     QIVKYKINMSTYGVYDAGQVNLLDEVNSALEISNIKYSDNLELKKEAGDGKNTIRLVN
                     KYEFKQIKEGEPVQSWVTFDADFTNVKVGETIQNVAQINGSSPPGVETTKQGYAFEAK
                     KVDALDKNVLSGAKFNLEDAFGNIVVKDLVSDEDGIIQSSIKKPGTYYLVEIMAPSGY
                     EKLKDKIKVEIGNKDIGRIVDIGNIENIRQENPPVNPPAPPNTDEPIVNPPVPPSTDK
                     PRKPSSSSDTEDTIVINPPIPPSEDIINPPIPEVLNPPVPPSEEMIETPVKQIIPIPE
                     VVKPSVSEEKNNKVKDDTLVNPPVPPKTGDSTTIIGEILLVIGAIVGLIVLRRNKNTN
                     "
     regulatory      73254..73339
                     /regulatory_class="riboswitch"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF01051"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="cyclic di-GMP riboswitch class I; Derived by
                     automated computational analysis using gene prediction
                     method: cmsearch."
                     /bound_moiety="cyclic di-GMP"
                     /db_xref="RFAM:RF01051"
     gene            73439..74101
                     /gene="zmp1"
                     /locus_tag="KR257_000059"
     CDS             73439..74101
                     /gene="zmp1"
                     /locus_tag="KR257_000059"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861706.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="zinc metalloprotease Zmp1"
                     /protein_id="HBH0028791.1"
                     /translation="MRPSKKLLIAIISIFLISSVPVSAHADSTTIQQNKDTLSQIVVF
                     PTGNYDKNEANAMVNRLANIDGKYLNALKQNNLKIKLLSGKLTDEKEYAYLKGVVPKG
                     WEGTGKTWDDVPGLGGSTVALRIGFSNKGKGHDAINLELHETAHAIDHIVLNDISKSA
                     QFKQIFAKEGRSLGNVNYLGVYAEEFFAESFAYYYLNQDTNSKLKSACPQTYSFLQNL
                     AK"
     gene            complement(74223..75185)
                     /locus_tag="KR257_000060"
     CDS             complement(74223..75185)
                     /locus_tag="KR257_000060"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728946.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="EamA family transporter"
                     /protein_id="HBH0028792.1"
                     /translation="MKKGYVYIILTTLFFSSMEISLKTVTNDFNPLQITLSRFFVGGL
                     VLLPFAVKRLRALSLSITKSDLKYFAFLGFMCVVVSMSLYQLAVLNTKASVVAVLFSC
                     NPVFVMLLAYLILKEKIYRHNVISLILEVLGIIVIINPLHTKLTLSGIFLTLSSAIIF
                     SMYTVFGKRKTLKFGGIVVTCFSFIFGSLEMLILVLLTKINFIADILNKNKLHVFANI
                     PIFSGYTLHNMPIMIYVFVFVTGVGYALYFMAMEATSTSLTSLVFFFKPVISPILALL
                     ILKEIIPINMVIGILLIVIGSIISIIPTIITQMHNKHVEALYKE"
     gene            complement(75355..76545)
                     /locus_tag="KR257_000061"
     CDS             complement(75355..76545)
                     /locus_tag="KR257_000061"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422792.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pyridoxal phosphate-dependent aminotransferase"
                     /protein_id="HBH0028793.1"
                     /translation="MISNKMQTLVANSSVIRAMFEEGKKLSDIYGEENVFDFSIGNPS
                     VEPPETIKAVINDILNEESPNLVHGYMNNSGYEDVRDAIAEHINKKDGLNLTRENLIM
                     TCGAAGGLNIILKTLLNPGDEVIAFAPYFGEYKNYTENYDGKLIEVPTNIETFEPDLD
                     ALKNAITPKTRALIINTPNNPTGVIYSEELLKNLGELLDSKQKEFNTSIYLISDEPYR
                     EIIYDGAKVPCVLKYYRNSFIGYSYSKSLSLPGERIGYIVANGQMDDFDDVMSSLNVA
                     NRILGFVNAPSLFQRVIARSLDAEVDVNIYKKNFDLLYNSLIDMGYSCVKPNGTFYLF
                     PKAPIEDDKKFCNDAKQFNLLLVPGSSFGCPGHFRVSYCVSYDKVKSSLPAFEKLAKL
                     YNLK"
     gene            76851..77297
                     /locus_tag="KR257_000062"
     CDS             76851..77297
                     /locus_tag="KR257_000062"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436142.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="winged helix-turn-helix transcriptional
                     regulator"
                     /protein_id="HBH0028794.1"
                     /translation="MDFKNLQYESLSYIICNLQKNFKLYCEKCLKPYKLTNGLYFYLI
                     YINKNRNCSLNDVSTEFEVDKAHTTRTISRLEQDGYIEKIQNPNDSRAFQLRVTDKGE
                     EVLGDIKNIFSKWDNHIKKEFSDTEYKELVKNLHVVKDIKTAVEEE"
     gene            77299..78393
                     /locus_tag="KR257_000063"
     CDS             77299..78393
                     /locus_tag="KR257_000063"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728945.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NADH:flavin oxidoreductase"
                     /protein_id="HBH0028795.1"
                     /translation="MYCNLLKPIKIGNLELKNRVSFAPTSMGLKLEEKIKKFSDIAKS
                     GVALITLGDVSIRPSFHKVAISLSDEDGVMKYKKIVDEIHNSGAKVSAQLFCSDYDVN
                     LIKDTMNMGITSHDEIKKIMNDGVKDYITNMPKEEIKNIINLFKVTALNAKKAGFDMI
                     QIHGDRLVGSFSSSIFNNRNDEYGRTCDNRSRFASEIISSIRDEVKDIPIDYKFAIRQ
                     ENPHYGNAGVLLSEVEYFVKKFESLGVNSFHVTLANHSKLEDTIPTNNHPYFKEEGCF
                     LYLADEVKKHTNLPVCGVGKLSSPDFIESIISNNRVDMVSMSRQLLADRNWLQKVKDG
                     RVDEIKKCCYCNKKCADALQTRSQFGCILD"
     gene            78481..79011
                     /locus_tag="KR257_000064"
     CDS             78481..79011
                     /locus_tag="KR257_000064"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436147.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flavodoxin family protein"
                     /protein_id="HBH0028796.1"
                     /translation="MKSLVLYSSLTGNTKKIAYTIYDEIQEEKDIKDVNELVDYSIDY
                     ENYDIVFLGYWVDKGICDKNSKQVLENIHNKKIALFGTMGASKKGSYGASIIEKIESI
                     IPKDNEILGSFICQGKIAEGLKAKYKEMLKLSPDNEHIRQQLNNHEESQSHPDEQEIY
                     EASMFAKNMMIKASIV"
     gene            complement(79948..81324)
                     /locus_tag="KR257_000065"
     CDS             complement(79948..81324)
                     /locus_tag="KR257_000065"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436150.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0028797.1"
                     /translation="MKYKIGFLTTSYFMSDKFKQALKELNDTCEITFIELKGENPFNN
                     LPNIYYEQVDNFDGFVCSGIVPYSELIINIKDIKVPLNFLKLDERDFYKYLFKLLNSQ
                     KDIDFTKSFMDFLREDNNYYDIYSLIDSNKCPYTIKDFNIPQPVYDFKKLNDKLLEIH
                     LDLLRDNKINLSFTRNYIISCELNKLGYDCIYMVPSTESILNTFKSLVNEITLQNLDK
                     NKSATCIVTVNSSEYINEDLIFKNDEIQNQIYNTILNSLSRHGFYGVQVKKNDMKIEI
                     HTTKEMLNNMTNNYTDFFISEDLKEIKYSLNIGWGIGNTNIHAEQNARQANGKSASLN
                     GNCTFIVNDTNDTIGPLYSNKNSNNIEDSSIANKVASFIPLSNTNVSKIMCMINDRNS
                     NNVSAEILSNYMNITLRSANRILSILYKAGIATIVNTKLDNQRGRPKKIYKVDFLSFL
                     NKMQKLNS"
     gene            81592..82764
                     /locus_tag="KR257_000066"
     CDS             81592..82764
                     /locus_tag="KR257_000066"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436151.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="M20 family metallopeptidase"
                     /protein_id="HBH0028798.1"
                     /translation="MNTYLNEISKFVDENREEIVSLWKEIVNIESYTHCKESVNKLAK
                     RLKFEFEKEGLDCELVDVGDNGSTLIGTLGSNINKKPIIFSGHMDTVFETGTFGENPF
                     KIIEGKAYGPGVLDMKGGIIISLYVIKALNKIGYKERPIKIVFSGDEEIGHKDSTGAD
                     VILREAKGGLCAFNMETGLVDNSLCVGRKGRIGCNIHVKGVETHAGNDFEGGRNAIEE
                     MANKILRIQKLTNLDVGTTVSVSVIKGGRVENSIPEDCSIKVDLRFEKVEEMENVKEQ
                     VREICKETYIEGTSTEVNFISEMMPFETTEDVMRFHTFVNEVSKENGFGELNAKRLGG
                     SSDASYLTIANVPAICSFGVRGEWNHTSREYAVVDSMFERVKLISTVILNLDKFEV"
     gene            82778..83425
                     /locus_tag="KR257_000067"
     CDS             82778..83425
                     /locus_tag="KR257_000067"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003431751.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0028799.1"
                     /translation="MDVTAGDNKVTWKGYLSLFVLIVLFSGVFKDSQGFLKALDFANL
                     TGSFGTIADGVDFMGKGGTGAKDGFLFALTLIPTVCFAVGLIDVVESMGGMKAASKIF
                     NPLLRPLLGIPGIAGIAFVSSFTSSDVASIMTKELFESGEITDDERTIFVAYQYAGSA
                     VILNTINTQAPLLPIALLALGPIILIEIFCKILGANLVRLIIGVRNKKNKAKEAV"
     gene            83427..83936
                     /locus_tag="KR257_000068"
     CDS             83427..83936
                     /locus_tag="KR257_000068"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426630.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nucleoside recognition protein"
                     /protein_id="HBH0028800.1"
                     /translation="MSQQNTGNAIVNSKPKKTAVEIFMGGAKKGFYIGVEQILPAMIM
                     GYVIVQFLQLTGLVDILGNIFGPVMGIFGLPGESVLVLIAAFFAKAAGAATAANLFAQ
                     GLITAPQATILIMPCMLMGTLVGHYARIVLVANASTKYRMLLLAVPIFDAIVGMLIVR
                     VLLTVMGLM"
     gene            complement(84300..85412)
                     /locus_tag="KR257_000069"
     CDS             complement(84300..85412)
                     /locus_tag="KR257_000069"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422798.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alanine racemase"
                     /protein_id="HBH0028801.1"
                     /translation="MKISEVATPNFLLDLDQLEKNIDKIQQICTNNNKQLWPMLKTHK
                     STYIARLQKNAGASGFLVGTLDEGEALIKAGFEDIMLAYPYMGEVNINRIVTMASKIN
                     LICATDNIECAKAYSEAFSKSKIECKLLIIVDCGLHRFGVEPEKVVELATEISKLENI
                     KIVGISSHPGQVYGCSSPEGVPDVCVQEDSSMEKAYKALTDNGFNIEIVASGSTPTVE
                     SEAASKTITAVRPGNYVYYDAIQIGLGCATEDMCALTVVCTVISKNSSGYYLIDCGSK
                     CLGLDKGAHGNSSIVGYGRVCGHPELTIDSLSEEVGKIKVNGETDIKIGDRIRIIPNH
                     SCSTANLTSNLLGFRGDTIEKVIEVDIRENSKQIIL"
     gene            85710..85976
                     /locus_tag="KR257_000070"
     CDS             85710..85976
                     /locus_tag="KR257_000070"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893732.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dihydrofolate reductase family protein"
                     /protein_id="HBH0028802.1"
                     /translation="MNLEPKKLIEQIGKEKDKKDIWIVGGGDIVKLFMKDNLIDDYYI
                     YILPIILGRGISLFKSGIDKTNLNFKKASNIGELVKLEYSKKQK"
     gene            86221..87948
                     /locus_tag="KR257_000071"
     CDS             86221..87948
                     /locus_tag="KR257_000071"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003496244.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBH0028803.1"
                     /translation="MKLILSYLKNYKLLIVLNILAIFSFALVELGIPTIIAKIIDNGI
                     ANQNIAYIKQMGIVIVIISIIGVVGSILLGYCSAKVSTSVTRDIRNDIFEKSQEFSHT
                     EYNKFGISSMITRTTNDAFQIQQFVNILLRTALLTPVMFIISIIMTIRTSVELSIVLA
                     ISVPFIIIGVAIIAKVSQAISSKQQKGLDKLNLISRENLTGIRVIRAFGNDDYETERF
                     EKTNTYYANVSKKLFKLMSITQPAFFLLLNIAVLAVFWISSEKINIGELQVGQLVAFL
                     EYLFHAMFSIMLFSMVFIMYPRAEVSANRIKELLNEEPLIKNPENGIKDTENKGIIEF
                     DNVTFTYPDGEASVLKDISFTAKTGETVAFIGSTGSGKSTLINLIPRFYDVTEGSIKI
                     NGVDIREYDLKALRKKIGFIPQKSLLFTGSIANNIRFGKHKAGESELEYSAKVAQAYE
                     FISKKPRKFDELISEGGANVSGGQKQRLSIARAIIRRPEIYIFDDSFSALDFKTDAIL
                     RAKLKKETKDAIVLIVAQRISSIIDADKIIVLNEGQVVGMGTHKELLKNCEIYYEIAT
                     SQLKKEELE"
     gene            87948..89738
                     /locus_tag="KR257_000072"
     CDS             87948..89738
                     /locus_tag="KR257_000072"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426617.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBH0028804.1"
                     /translation="MKKSKGFKKTIGRLLPFVKKYKFSFIIAIICIISAATMNALAPK
                     TEGLIITQLTKDVISIAKGVPGASVNFDYVTKILVILACIYFANAIFTYTSSFLLTNA
                     IQNTMRDLRNEVENKIRRLPISYFDSNSFGDVLSRISNDVDTISNALQQSFMQIVNSI
                     LVIILALSMMFTINIYMALIALFIIPISYFVSKFVVKKSQSRFSLQQNALGKLNGKVQ
                     EMYTGFNEIKLYGKEEDSIKEFKKVNQELCENGFKAQFISSMMNPMVSLVTYFGIAAV
                     AVVGSIYAVSGGITVGNLQAFVRYIWQINQPLSQMTQLSTVIQSSFAAIERVFEILDE
                     EEEIPDVENPVKIENVKGNVTFEHVNFGYGENSTLIEDLNAEVKSGQMVAIVGPTGAG
                     KTTLINLLMRFYDVKKGAIKIDGVDIRDMKRKDLRSMFGMVLQDTWLFNGTIFENIEY
                     GRFGATKEEIIQAAKVANVHHFITTLPDGYNMFLNEEASNISLGEKQLLTIARAFISD
                     PSILILDEATSSVDTRLELMLQKAMRNLMNGRTSFVIAHRLSTIRNADLILVMNNGSI
                     IEQGNHDELMEKGGFYEKLYNSQFADKESE"
     gene            complement(89900..90208)
                     /locus_tag="KR257_000073"
     CDS             complement(89900..90208)
                     /locus_tag="KR257_000073"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422803.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0028805.1"
                     /translation="MFNKIYEKKEFIVFQVKKGYVVYNTRKSFEEGHTHLKHFEAAKT
                     AIDLAINKKIPRSKDGYYLTSLIRISDDGYYIDKLSELLYVREQKGKKEKYCNSGYQM
                     "
     gene            complement(90470..91018)
                     /locus_tag="KR257_000074"
     CDS             complement(90470..91018)
                     /locus_tag="KR257_000074"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454071.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0028806.1"
                     /translation="MIFLNEDVVTNETIDKDYAIEEVRMACKHFGDLYFYFSKVLFEE
                     FGEDKTSEILRKVLFERSEERAIAMRERAHENGDELIADNIISTTDVPFLGWVPEFEE
                     LHCPYGASWLLRFEENPWFKKFASLYCDVTDTTVAEVFTGDTSHKITKNILWGDKSCE
                     RIYFHDDKVSEGKYTYGNKNCK"
     gene            complement(91121..91792)
                     /locus_tag="KR257_000075"
     CDS             complement(91121..91792)
                     /locus_tag="KR257_000075"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422805.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GntR family transcriptional regulator"
                     /protein_id="HBH0028807.1"
                     /translation="MATFKRLQEQAYDYLKELILSGEMIENEIYSETKLASEIGISRT
                     PIRDALQRLSQDGFIDIIPSKGFRIHQITANEIVEIFQIRSAIEGFCTFLITSQYKEA
                     RAVETISKLKHLLDKQKDILLGDKNLNSFAEYDTLFHTTIVSYAQNTEFDKMFNNYMY
                     RIKKLALDSLSHEGRLETTLKEHTDIFNNIANGCIEDIYRTTLIHMETPKYINLEDFC
                     NNKLF"
     gene            92188..93093
                     /gene="garR"
                     /locus_tag="KR257_000076"
     CDS             92188..93093
                     /gene="garR"
                     /locus_tag="KR257_000076"
                     /EC_number="1.1.1.60"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426591.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="2-hydroxy-3-oxopropionate reductase"
                     /protein_id="HBH0028808.1"
                     /translation="MEGYKMKLGFIGLGIMGKPMAKNLLKDGCNLLVYDINKSAVDEL
                     ISCGAKYASVLEMGQECDIVFTILPNGTIVQDILFGMDGLAKTLKEGSIVVDMSSVTP
                     TESILCANKLKDMGLEFIDSPVSGGEPKAIDGTLAFMAGGKEEIYKKVEPFFNIMGSS
                     SILIGDNGSGSVTKLTNQVIVNLTIAAVSEAFVLAAKAGADPEKVYKAIRGGLAGSTI
                     LDAKIPMIMNRDFKPGGKISINLKDIKNVMQTAHNLDVPLPMTSQLLEIMQTLKVHGH
                     LEDDHSGIAQYFEKLAGVEIKKHNN"
     gene            93229..94611
                     /locus_tag="KR257_000077"
     CDS             93229..94611
                     /locus_tag="KR257_000077"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422807.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GntP family permease"
                     /protein_id="HBH0028809.1"
                     /translation="MITGYGLLIAFVISIGILLVSIIKFKVNPFLALLITSIITGFMV
                     RMPINEISTTISTGFGNTLGSIGIVIGLGIIFGNILSESRATESIAKGLLAKTGEKNS
                     ALAVTTAGFLISIPVFMDAAFVIMMPIIKYVSRVTKKSLMVFVCALGVGTIVGHALVI
                     PTPGPLAVAANVNANVGSFILYSIIVAFPAALIGGWIYGKRFEKYPAYAIDENDREKN
                     LEQGKDSIKIEDDDSSKVPGFGISMFSLLFPILLILISNVFSMFLEKGSTMSGVLAFI
                     GDKNIAILLGILVAIGFLKKYINKPMGDVVIEAADSAGLILLITGSGGAFGSVINASG
                     IGNFLVDTMSGLSISVVVLGFLLSALLRISQGSATVALVTTSSILGPTILATGMSPVL
                     VGLAICAGGVGFSLPNDSGFWVLSRFSGLSVKDTLNSWTIGGTIAGVVAFIMVLLLSV
                     INGIIPLPGL"
     gene            94682..96118
                     /locus_tag="KR257_000078"
     CDS             94682..96118
                     /locus_tag="KR257_000078"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426589.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hydroxyacid dehydrogenase"
                     /protein_id="HBH0028810.1"
                     /translation="MREVKPISIDILNTFKQVDEDRLNKLLADELKHLDRKIVVLDDD
                     PTGVQTVHDISVYTDWDKDSMEQGFNEKNSMFFILTNSRGFTVAQTTKAHKEISKNIV
                     DVSKKVNKDFIIISRSDSTMRGHYPLETNLLKSEVERLSEKLFQGEIIMPFFKEGGRF
                     TIDNVHYVKEGEILVPAGMTEFAKDKSFGYKSSDIGEWCEEKTNGKYKSSDMIYISSK
                     ELRELNIEAITEKLKKAEGFNKIIVNATDYVDVKVFTIAFIRAVNSGKEFMFRSAAAI
                     TKILGGVSDKELLTKDELVSKGNTNGGIILVGSHVNKTTQQLEELKNCKYPIEFIEFN
                     QHLVLQENGLKNEVKRVIKVVEEKISRGKTVAVYTRRERFDLDTNDKDKQLMISVEIS
                     DAVTSIIGMLNVRPNFIIAKGGITSSDVGTKALRVKKATVMGQIKPGIPVWMTGKESK
                     FPNMPYIIFPGNVGEISTLRESVEILMG"
     gene            complement(96304..97158)
                     /locus_tag="KR257_000079"
     CDS             complement(96304..97158)
                     /locus_tag="KR257_000079"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454079.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0028811.1"
                     /translation="MSTFYIQFLYFVIYSFIGWCCETTYCSVLQKQFVNRGFLNGPFC
                     PIYGFGALAIVATLTPFVHTIPLLFLFSIIITSIMEYCTSFILEKIFNMTWWDYSKHK
                     FNIHGRVCLENSLMFGVLSLIVMLIVHPIVVDFINSISKNVLFIFAISIEIYFVLDLV
                     ITVHTILQLNGKLKQINLIIKELKDKKEYYKLITQETIENKLESLVENRLDTLEDRFE
                     ILKEKENYRYAKNRIDELKNKLNTLLSNHKLLHRRIIKAFPNISSNKHTDILNKIKEN
                     IKSIKKDK"
     gene            complement(97426..97749)
                     /locus_tag="KR257_000080"
     CDS             complement(97426..97749)
                     /locus_tag="KR257_000080"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422812.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1540 domain-containing protein"
                     /protein_id="HBH0028812.1"
                     /translation="MERINCNVINCSHNNSHICYADKIFINGEKAHNDRHTCCSSFLD
                     ESIYSNLSSNVNNRNCEELVCTVKNCKYNKDGSLCTLDNILVAPETDRVNLYIETCCS
                     SFECK"
     gene            97952..98581
                     /locus_tag="KR257_000081"
     CDS             97952..98581
                     /locus_tag="KR257_000081"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897973.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0028813.1"
                     /translation="MFEKKKKELFPWKISALILVGVFVLSSGVYIGTRLKHNGVQTGE
                     VVSTSANMNEKSKEAFGLNKNCEVWLQSEGENETNYKRTLTMAGIVPESLLDKTKSEI
                     VSYFKKEYPTKKIKSMDKNEIILVESKYSDNKDVQAMDVTIKGKYTIENDNGNIALYK
                     YDDSGSKTLVEKTKIRVDSLPKTVQDEIKKGVVMDTEEEAYSRLEDFAS"
     gene            98924..99433
                     /gene="ruvC"
                     /locus_tag="KR257_000082"
     CDS             98924..99433
                     /gene="ruvC"
                     /locus_tag="KR257_000082"
                     /EC_number="3.1.22.4"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422814.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="crossover junction endodeoxyribonuclease RuvC"
                     /protein_id="HBH0028814.1"
                     /translation="MIILGIDPGIAIVGYGIIEYKNSKFKVIDYGAVTTPAHMNISRR
                     LELVYKGIDTIVKNYNIDEVGMEELFFNKNVKTAITVAQARGVTMLACAHNGKPVYEY
                     TPLQVKQGVVGYGRADKAQVQQMVTSFLSLKKVPKPDDVADALAVAICHAHSNKLEKT
                     LKNIGGKYV"
     gene            99426..100028
                     /gene="ruvA"
                     /locus_tag="KR257_000083"
     CDS             99426..100028
                     /gene="ruvA"
                     /locus_tag="KR257_000083"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891076.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Holliday junction branch migration protein RuvA"
                     /protein_id="HBH0028815.1"
                     /translation="MYSYIKGTVEEIYIDSIVVENNGIGYKINVSSNTIMNLQVGEAT
                     KIYTKLIVREDDMSLCGFVSREELKMFELLTSVSKIGPKVALSILSFASPAQLGAYIL
                     SEDIGKLSKAPGVGKKTAERIVLELKDKVDKNNIEFEPTLLSQKPTLISQDESVDALV
                     ALGYTLSESKEAVQKCKKDGMNTEAIIKKALTYIMSKSLK"
     gene            100135..101154
                     /gene="ruvB"
                     /locus_tag="KR257_000084"
     CDS             100135..101154
                     /gene="ruvB"
                     /locus_tag="KR257_000084"
                     /EC_number="3.6.4.12"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422816.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Holliday junction branch migration DNA helicase
                     RuvB"
                     /protein_id="HBH0028816.1"
                     /translation="MQGFEDENRIITSTMKMEDIDIENSLRPKTLEDYLGQEKSKEQL
                     SIFIEAAKSRNEQLDHVLLYGPPGLGKTTLASIIANEMGVNLRITSGPAIERAGDLAA
                     ILTNLNENDVLFIDEIHRINRSVEEVLYPAMEDFCLDIIIGKGPSARSIRLDLPKFTL
                     IGATTRAGMLTNPLRDRFGVICKLDYYTVDELSKIVLRSSSILDAEIQSNGALELAKR
                     SRGTPRIANRLLKRVRDFAQVRADGKITDKVAKDALELLGVDSLGLDFVDEKLLMTII
                     EKFRGGPVGLDTLAASIGEDRNTIEDVYEPYLLQLGFINRGPRGRVAMPLAYEHLKIP
                     YPNEK"
     gene            101472..102497
                     /gene="queA"
                     /locus_tag="KR257_000085"
     CDS             101472..102497
                     /gene="queA"
                     /locus_tag="KR257_000085"
                     /EC_number="2.4.99.17"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861694.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA preQ1(34) S-adenosylmethionine
                     ribosyltransferase-isomerase QueA"
                     /protein_id="HBH0028817.1"
                     /translation="MKTSDFKFDLPQELIAQVPIEDRASSRLMVLDKETGNIEHKVFR
                     DIIEYLNPGDCLVLNNTRVIPARLIGEKLETGGKIEFLLLKRTEEDTWQALVKPGKRA
                     KVGTKFSFGNGKLIGEVVDLSDEGSRIIKFHYDGIFEEILDELGNMPLPPYITARLDE
                     KERYQTVYSKHNGSAAAPTAGLHFTEELLNKIKEKGVDIAFVTLHVGLGTFRPVKVED
                     VLNHKMHSEYYMVSQEAADKINRAKENGKNVICVGTTSCRTIESACNEYGKMKETSGW
                     TEIFIYPGYKFKVLDKLITNFHLPESTLIMLVSAICGKDNVLNAYNEAVKERYRFFSF
                     GDAMIIK"
     gene            102509..102994
                     /locus_tag="KR257_000086"
     CDS             102509..102994
                     /locus_tag="KR257_000086"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422818.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0028818.1"
                     /translation="MHSLQKQKKNNPILKIAFIFERVLAVVVLIAVFLGTIDVLRLMW
                     GAYIVDFQNPVQYSQLNDFLAQILLLVIGVELVVMLSLHIPGAFIEALLYAIARKMLL
                     LPKNEGMIDVLIGVIAIAGLFAIKKFLVTKDKSALNIMSIHDEEAIKEQQNKEDEDKS
                     I"
     gene            103073..104194
                     /gene="tgt"
                     /locus_tag="KR257_000087"
     CDS             103073..104194
                     /gene="tgt"
                     /locus_tag="KR257_000087"
                     /EC_number="2.4.2.29"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009906124.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA guanosine(34) transglycosylase Tgt"
                     /protein_id="HBH0028819.1"
                     /translation="MYAVRYELIKTCKQSGARLGRLHTPHGIIETPIFMPVGTQATVK
                     SMTPEELKEIGSQIILSNTYHLYMRPGHELIKRAGGLHKFMNWDKPILTDSGGFQVFS
                     LGPLRKIKEEGVEFRSHLDGSKHFLTPEKAMEIQNALGSDIMMAFDECAPYPSDREYV
                     KNSLERTTRWLKRCKDAHNNTDKQALFGIIQGGMYKDLREQSAKEITNIDLPGYAIGG
                     LSVGEPKPLMYDVLEHTTPLMPKDKPRYLMGVGSPDDLVEGVIRGVDMFDCVLPTRIA
                     RNGTAMTSQGKVVVRNATYAEDFTPLDPECDCYACKNYSRAYIRHLIKANEILGARLI
                     TTHNLHFLLNLMKQIRQAIMEDRLLDFRNEFFAKYGYEI"
     gene            104328..104621
                     /gene="yajC"
                     /locus_tag="KR257_000088"
     CDS             104328..104621
                     /gene="yajC"
                     /locus_tag="KR257_000088"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426573.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="preprotein translocase subunit YajC"
                     /protein_id="HBH0028820.1"
                     /translation="MPQQQIIMSIGLWVVVIAIFYFLMIRPQKKKDKQLKEMRSSLSV
                     GDKVITIGGIVANVAKVEDDVVILELGPNRTKVPFEKWAIGTVKSKKEEIEED"
     gene            104679..105041
                     /locus_tag="KR257_000089"
     CDS             104679..105041
                     /locus_tag="KR257_000089"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454083.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TIGR04086 family membrane protein"
                     /protein_id="HBH0028821.1"
                     /translation="MGKSNYIFKGLGYAYIITLAVLLVYNLFLTFTDIGGDNITMVSS
                     FITTISAAIGGFYTSKHMKEKGLMYGLLVGLLYIVCIFLTVFLAQEKFVFEIGMIYKL
                     LLISAAGGIGGVLGVNFK"
     gene            105107..105250
                     /gene="scfA"
                     /locus_tag="KR257_000090"
     CDS             105107..105250
                     /gene="scfA"
                     /locus_tag="KR257_000090"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891067.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="six-cysteine ranthipeptide SCIFF"
                     /protein_id="HBH0028822.1"
                     /translation="MENKHVKTLSQATLKQSAAKGGCGECQTSCQSACKTSCTVANQE
                     CER"
     gene            105877..107772
                     /locus_tag="KR257_000091"
     CDS             105877..107772
                     /locus_tag="KR257_000091"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861692.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell wall-binding protein Cwp8"
                     /protein_id="HBH0028823.1"
                     /translation="MLSNKKRSMAIVMAGATVMSAAAPIFADNTVTENVDKNYTVSAK
                     DSAKLIEEVRKALEVKFEDTKAGANVNDRVYDIKVDNVNLTNATQLQNKINSLTEGQS
                     LKVTIQDKGHQVLGGKVVDYKIENYKTAQEIVDAVNAYNATLAEDSDNKLTATIKSTN
                     TVEVKRAKDSANVITLNVGDQHLDFSKVITSEEGTFEGYEKSYSDIDSKELHTITVKN
                     ADLQDISAEELFDGIRLTTLGREIVNKVKNGYALTFENEAILTQEQEDSDDKDKPEKS
                     SFDIVLSKANEKPETISVSSKNHKLVRDLHKVLTDVKDGKELKVEVLSGDSRFTTAVE
                     VSKERFKDGEAEAIILVGEDAIVDGLASAPLASQKNAPILLSKKDSLPSEIEAEILRV
                     LGSNLSSKKIYIVGGESKVSKETEEKLSKLGVSKVERVSGEDRFETSLEIAKQLKDTF
                     KTAFVVGGNGEADAMSISARAAQFGAPIIVTGNELDANAEKLLKGKELEIVGGENSVS
                     KEVEDKLVDIDLNNKVERLAGENRKDTNAKVINKYYAGATKAYVAKDGYVGGNGQLVD
                     ALTAAPLAASSKAPIVLTTEELSKSQEEVVELRLKNATKLVQIGEGIAKNAIEKIAEK
                     INLFTKN"
     gene            108234..109637
                     /locus_tag="KR257_000092"
     CDS             108234..109637
                     /locus_tag="KR257_000092"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861691.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell wall-binding protein Cwp9"
                     /protein_id="HBH0028824.1"
                     /translation="MKNSKKILAIGLTLFLVMVNTPMVNALTSVEQIKGNDRYETAAK
                     IADKQNYNTAILINSDNSLADGLSASGLAGALNAPILMTKQNQIPNTTMERLNKAKTV
                     YIIGSESTISKNVENQLLSKKKVVQRIFGENRFDTSIKIAEKIKEIKPIDKVIIANGF
                     TGEADAISASPVAARDGVPIILTDGNSVGFDTTGLKSYALGSSEIISDELVKSTNSIR
                     LGGTDRFETNKIVIQEFYKNSKEFYLSKGLQLTDALAASTIAKNAPVVLVENGSNKSI
                     LSGADKLTVLGGINQNVIKQCINQASPNQQGLYYNPNDRAFKERIKGKVYALTKQYRK
                     ENGVRALSVASRLEGLANDWSNLMANKKTLSHTINGKNSYSTFLKYLDWSEIKPGYIA
                     VQGENIIKYKIPDKPVYTNRDADDIGNFIFNEWKTNPEEGTNMLHKGYEIMGFGIAIT
                     GDKNLYATHEFYGRYKE"
     regulatory      109809..109894
                     /regulatory_class="riboswitch"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF01051"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="cyclic di-GMP riboswitch class I; Derived by
                     automated computational analysis using gene prediction
                     method: cmsearch."
                     /bound_moiety="cyclic di-GMP"
                     /db_xref="RFAM:RF01051"
     gene            110018..115981
                     /locus_tag="KR257_000093"
     CDS             110018..115981
                     /locus_tag="KR257_000093"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903330.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="calcium-binding adhesion protein"
                     /protein_id="HBH0028825.1"
                     /translation="MKKAISCVLAVSMCSAPLNVFAEPILEGKLRAVEKSVTEKLRGS
                     LEVDLNFSLPIKNSESESMTNMQLRLKDDSNNSGIIKLGEKDSGTVNVGTDNIEYTIK
                     KLSASRSEIKNKDENISYYNIVFNNLPVGKYNVEVSGDGFKNKEIKDIDISSYSQRVL
                     LSNRASVDNKNKPLNYELFLMGDVNGDGKVDKSDYNKVLENIDSNKREFDLNRDGKVD
                     IVDLDYVQKNLGQSEDAKSLESIVSTNPIVDTSKVELKGNSDVDINGNVENLFSGENN
                     GVTISSKNDEISEEKPAVMDIALSEALNMEVINIKAPEGTAPAKGIVEVTDKDGNVQQ
                     IPYENKEYMKNLKDEEQQEEVNNEQEEVNQEEVNNKDENINQTDNNSNNKDENNDKQQ
                     ENSDKQEANSNTNQDKNNDKENSSMDKPNSDEDTPKEEGNISKDDNSTTSTYSRSALE
                     TYADVQNSDIVINLGKQVAVKKITIKITATTANDRNLAEISKVEFLNNVYKEIPKPEM
                     NIPKINKISTSTAVGNEKVSFYWNNEVNVSAYELILDKIDSKGKVLSTKKLQTSKNTI
                     EVRDIEAYGLYRVSIQSLNGDWSSGYKDATPENLDGVPENVDSNYKPIQFSPDSILEF
                     QVVPDTKPEPPEGINVKGKFKSLDVSWKNHKQAKDFDLYYKEKGSNGSWIKYNDKLIR
                     GTSSKIEGLKDNTTYEVRMTATNHLGTSGMSKTYIGTTESMDAPTTPNYRLINTPKEN
                     GGFGIPTNHIVDVVYPDGYDKSEYSDKNPFDKFNVVDGDFTTHWTFPTYNAAEGTNRG
                     PIITFDKSYTMDTFMATPRFDVSDKTINDFEVRYWDENGQLHNLGDVPFETKTDPVNN
                     NKYVMVRLKEPITATKIQVSVCSSYSYKSNISELKFYEYDSIEDDVRNLFMDGLQVEL
                     KEDVTQEKITELKDRLNTPDKASGEYHPYKTVIERELKLAQDLYNDRATLTDVTTVNQ
                     EINKLGKYKDKNGQYTVNSNNLGMQNDWQALGVAARAGDEITVYVGSKSGKTPKLIYT
                     QYYGESGAYKSGEINLNTGKNVIQLSKLHSLDIECGGSLYIRYAEDTPSGGDIKVRVA
                     GATKIPHLNLNGTINDKSPAGVSESKKKIKAYIEELAKYKDAVKGEPYYPGTNVGNSY
                     GYSEKTGVLNTTDIESDKVTLNVPATAVYQEISKGNSDLNTQVDRLYNSMLAWEQIMD
                     LVYSERGVFKTQDLDGNGTVDDNEFNLTKNDMAPKSRMNIKYQRMFIGAFMYASGLHV
                     GVEYGSVPGLMNGVPFQIDDSGKATGGNLFGWGIGHEIGHVTDIGKMTYSETSNNVLA
                     LLAQTFDDKTHSRLEGSTMDKIYEHVTSNSLGIPSNVFERLGMLWQLHLAYDDDFTGS
                     MLKNNSDADLSNDTFYAKISRKYRALSSSDPINSLPKDQMLVAMASSVVEKDLRDYFK
                     AWGVEITPELNSIMDSKNYEKESRKIQYVNDEARRKILNENIASMAKDTKVSASFSDG
                     IQSGSLVKSNKISIDLDVDKDKDKILGYEIIRSDGNYLDGENGTQVKYRTVGFVDAKG
                     NSKTKFTDNISPLNNRAFTYKVVAYDYHLNPTEEFEVGTVKLSDEGKINKSAWSFITN
                     TVSDGDVRTENDSHGPLQNPEIDNIKDNDASTTYKGKIISKAEWNKDPQKDPDINVEE
                     NPYIIVDMKETLPIVGLKYTKPETEARKFSLKGLFNFRKNTSTTYNPLTNYKIQVSND
                     KKNWEDVSQGTFEYGQDLVGGGKDQDNEARVTFNKDGKLWTYQARYVKLISNNKSNIE
                     VAELDIIGPPGDNIEIGIINNADETRTNGIGKLAEDYVYQSDDSSTSEDETGKIPAGS
                     IVITGEYSGNPAFNLPLLIDKNNKTISGEALLFAEVPEKGELGEISKGTWVYYMPKEN
                     FDSLSDKVKAELYRYNDLQGDTPVGQRFVSDTMYVPVGAKNYDELKTISLTDSNSKAR
                     KATRNSIDISNKKVITVSNKVKGNIVRDK"
     gene            116185..118065
                     /locus_tag="KR257_000094"
     CDS             116185..118065
                     /locus_tag="KR257_000094"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861689.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell wall-binding protein Cwp10"
                     /protein_id="HBH0028826.1"
                     /translation="MSKRKSFIRTIAVSTMAVAVTGSATCAYAAPVLQGTKTYEKVNT
                     IDISVDSVENIVYSFQASIKVQGEVEVVDNEQKEKITWSDNIKSQIKSGNANATCRVE
                     YNKSSNTTTLDIYVTSNEDLLDGNRLNIGRISVKKSGSNSNADYKVLGKGTNDKPALK
                     IVTYNNKTVDYENISSDEGLIFTLINESEVKPIGGTGSSKNDPEKYKVEKSEALEYLL
                     NNIRINYSIVSKETQESGSNVILKLGLAQKTTKGRKATINKYVEVTLPKSLEYIVENE
                     LSKPDELPPDNGNGGNNGGGSNSGGSSSGGSSGGGSSSDSTSNVTVKKLKGADRFETA
                     IKISQSGWTKSDTVVIVNGEDKSMVDGLTATPLASVKNSPILLSSNEKLPQKTVEELK
                     RLNPSKVIVIGGNNSMPNSVVEAIKAVNSKISVQRIGGDTRYQTSINIAKEIDKTNNV
                     SKLYIGAGNGEADSLSIASLAGKEKTPIVLTQKDGVDNEAEQFIKSNKVSNIYFIGGV
                     EKISNKAIEQVGKIANKDISNNRVAGQTRQETNAKVIDKFYSQSKLDGVVVANQDKLI
                     DALAVGPLAAKNNSPVILATNTLDKSQESSLKGKNSSKLFEVGGGIASSVIDKIKSLI
                     EK"
     gene            118432..120033
                     /locus_tag="KR257_000095"
     CDS             118432..120033
                     /locus_tag="KR257_000095"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861688.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell wall-binding protein Cwp11"
                     /protein_id="HBH0028827.1"
                     /translation="MKMNKKILSLGLAVSLILVNFKSVNASSVVEKIYGKDRYETAAK
                     IADKQTYETVILVNTEKSLADGLSASGLSGATKAPILFTQQNKIPADTNRCLKNIKKA
                     YIIGTEDTISKSVEKELDSKNIEVKRIGGEDRLKTSYLIAKEIATIKKVDKVLLTNAY
                     SGEADAMSVSSVATRDGAPIILTDGKSVPFDVKNIQSYCIGSEEIMSNPLVKNTNSVR
                     IEGTDRFETNKNVIDYFFNSADGFYVSDGYQLVDAIAAAPLTKNSPMVLVNDGSDKTV
                     LEGAKNITSVGEINEKVIQQCINASNSNGQPPTITVGSTEVYKGEKFDTGKLNIVAKD
                     NTGKVLPIEVDGFIDTNRVGTYILTLKATDEWGKSTGKRVEIKVLDDKSHDYNSPEFK
                     KMVSTEMYNLINSYRKEKGKEPLLVSSRLEGMANAWSKYMMDKKVFAHYIDGKNAPQV
                     FSEFGMRSEENIAYIYIDSKNVQTTQDAKDLAKAIFEVWKKSPEYNANMLSNEFYSTG
                     FGLYILSDGQVHATQEFLNGNEGSL"
     gene            120252..121850
                     /locus_tag="KR257_000096"
     CDS             120252..121850
                     /locus_tag="KR257_000096"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861687.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell wall-binding repeat-containing protein"
                     /protein_id="HBH0028828.1"
                     /translation="MKVNKRVLSIGLTISLIMAGAPNINALSSIEKIQGKDRYETSAL
                     IADKQIYDTIILVNTDNSIVDGLSASGLSGVAKAPIMLVQRDKIPTDVEKRLKDVKNA
                     YVIGTEDTIGKSVENQLKNKGIEVKRIGGEDRIKTSYLIAKEISAIKPVNDGDKVFLV
                     NGYTGEADAMSVSSVAARDGVPVILTDGKSIPFKVDGVQCYSLGSEEIMSNELVSKTN
                     SVRIAGKDRFETNKKVIQRFYKGTKKFYVSQGYKLVDAVAGSPLAKDKPIVLVNDGSD
                     KSVLRGADEVTSLGGMDKKVVDQCISSASDKNTMPTITANDVEISVGDKFDNSMLNIV
                     ATDYYGNDLKANIKGNVDINKAGTYVLNISVVDNLGQKSEISVNVKVVVNASTKDSNS
                     YEFKAMVSNEMYDLVNSYRKEKGKKSLRELDSLAGMANAWSKYMEDKKVFAHEIDGKN
                     AAEVFFGFGARSGENIAYLPMNVKSVYTSKDAKEMAESIFDLWKKSSKYNENMLKEEF
                     YSFGFGMHVSSKGEVNATMEFLNS"
     gene            122140..124338
                     /gene="slpA"
                     /locus_tag="KR257_000097"
     CDS             122140..124338
                     /gene="slpA"
                     /locus_tag="KR257_000097"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454090.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="S-layer protein SlpA"
                     /protein_id="HBH0028829.1"
                     /translation="MNKKNLAMAMAAVTVVGSAAPIFADTTVKEEGYTVVQDKYEKLL
                     KELKAKIKDGTITSVGVEFDGKPITTLAPKADGSDKDAIAEQLETLTKNQLKGLGDGK
                     YVDFKITYGAKAEVPAASLSADDIQKYADQINASEKILVEVAAGSEAGIAKFDSVNNK
                     VIAGDAPLKVKDAVKATVTTNGSNKKVLTISAAAGLSGFSYGTLKDTGASSSDVDAIT
                     LDTTNATITEGDTKVLDFDNSFKFNESTKKVGSLVTPNTTNTPADPGTKTTVRVIKAV
                     EKTIDVSSNSTTKAKDLAKQYVFTDVSDTDPESLSYMLKNINDGKVAVKNSDGDYEVT
                     IFPEGKRLNTLSASSAKTILGDKDTPAKIVLKASTTKKLADYIDDLITYNNSYSNVQT
                     VAGSDRIETAIELSRKYYNSTDKNALYGDPVNNVVLVGSQAIVDGLVASPLAAEKDAP
                     LLLSSKDKLDSSTRAEIKRVMDLNSSTGIKNNKEVFIAGGVNSISKDVENELKDMGLK
                     VTRLSGDDRYETSLAIADEIDINDKAYVVGGTGLADAMSIAPVASQIKDGEATPIVVV
                     DGKSDKLSKEAEDFLDDAQVDIIGGENSVSAKMEDYIDDATGKSPERISGADRQATNA
                     EVIKEYFDKDGVSNYFLAKDGSTKEDQLVDALAAAAVAGNYGSKHNEDGDITTDASPA
                     PIILATDNLSAEQHVAVSKTATTNGAKNLVQVGQGIADSVVSKLKDLLDM"
     gene            124584..126926
                     /gene="secA"
                     /locus_tag="KR257_000098"
     CDS             124584..126926
                     /gene="secA"
                     /locus_tag="KR257_000098"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891056.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="preprotein translocase subunit SecA"
                     /protein_id="HBH0028830.1"
                     /translation="MSVLDVILDKTDELEIKKLNNIVDKIDALEDKIQILDDEALKNM
                     TNVFKDKLSKGETLDDILPEAFAVVREVSKRILGMRQYRVQLIGGIVLHQGKIAEMRT
                     GEGKTLVGVAPVYLNALTGKGVHVITVNDYLAQRDKELMQPVYEFLGLTVGVIINGQQ
                     PVERKLQYQCDITYGTNNEYGFDYLRDNMVTQKSEKVQRELNFAIVDEVDSILIDEAR
                     TPLIIAGGGDEGTKLYELANAFIKNIRDEDFEMDRKDKTIALTASGLSKAEKFFGIEN
                     ITHIDNIEIFHHVNQSLRAHKLMNIDVEYVVRDNEILIVDEFTGRIMDGRRFTDGLHQ
                     AIEAKEGVKINDESKTMATVTFQNFFRLYSKLSGMTGTAKTEESEFEATYKINVVQIP
                     TNKPVIRADLHDKVFKTERAKYNAVVEEIIRINKTKQPVLVGTVSIEKSEKLSKLLKK
                     KGVKHEVLNAKQHDKEAEIISKAGKLGSVTIATNMAGRGTDISLGAGDKEEEEKVKEL
                     GGLYVIGTERHETRRIDNQLRGRSGRQGDPGTSRFFVSLEDEVIKLYGGKSIEKILKR
                     MNANEDDALESKALNRAIERAQKGIEGKNFEQRKNVLKYDDTINEQRKVIYDERNKVL
                     DGSDIEEEIQKMVMDIITEAAEKYLKKFRDYHGYFKYLYNTFMPADTLLIPDLDKKNV
                     EEIVNQTYQISKRVYDLKKMMIGIEELAQLEKRVLLQVVDTYWVDHIDAMDQLRQYIG
                     LKSYAQKDPFKEYAIEGYEMFEALNRNIRITTVQYLYKFN"
     gene            127340..129211
                     /locus_tag="KR257_000099"
     CDS             127340..129211
                     /locus_tag="KR257_000099"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861684.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell wall-binding repeat-containing protein"
                     /protein_id="HBH0028831.1"
                     /translation="MNRKNLYVIMAAAMVSTSVAPSFAAEATQVKKQTITKKEATELV
                     SKVRELMAQRYTGGSQVGQPIYEIKVGETSSQLKIITNIDELEKLVNALGENKELLVT
                     IADKGHTTNSANEVVAEAIEKYENSADLSAEANSITEKAKTEATGIYGVATVEASYDS
                     TKDKLVITLKDKTDVVTSKTLQIGIGDEKVDLTANPVDIAGTNLDPSAEGFRVSKINK
                     LGVEGAKNIADIQLAEITIKNSDLNTVSPQDLYDGYRLTIRGNTIANSVGKSISDISS
                     KDSETGKYKFTVKYTDTSGKAIELTVESTNDKELKDVKDALNGNTKVNLIAGEDRYAT
                     AVAIAKETEYTDNIVIVNSNKLVDGLAATPLAQSKKAPILLASDNEIPKVTLDYIKEI
                     IKKSPSAKIYIVGGESAVSNTARKQLESVTKNVERLAGDDRHTTSVAVAKAMGSFKEA
                     FVVGAKGEADAMSIAAKAAELKAPIIVNGWNDLTADAIKLMDGKEIGIVGGSNNVPSQ
                     IENQLADIDKDRKVQRVEGETRHDTNAKVIETYYGKLDKLYIAKDGYGNNGMLVDALA
                     AGPLAAGKGPILLAKNDITNSQKNTLDKKLNLGAEVTQIGNGVELTVVQKIGKILGW"
     gene            129320..130027
                     /locus_tag="KR257_000100"
     CDS             129320..130027
                     /locus_tag="KR257_000100"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422831.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PIG-L family deacetylase"
                     /protein_id="HBH0028832.1"
                     /translation="MIEATLFFSPHQDDETLSMGSAIIEHVERSDTHVILCTDGSKSI
                     IRKVLDDGGSCSYHIKDVHKYSLSESDFSKNRDEEFKNSCKAMGVKENNIHIENNRAH
                     DGELSKEKARDIMLKYLEKYPDAKVKTVTPYKALGIHEDHRALGEAALELYREGKIKD
                     LRFYVEPYDYNDFKKVNPNVRVWKVLSSQEEKLLNAMDAYKKWNPENGNYAIGYHSVK
                     SHFDELKSNKIQYVHAP"
     gene            130060..132192
                     /locus_tag="KR257_000101"
     CDS             130060..132192
                     /locus_tag="KR257_000101"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728928.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell wall-binding repeat-containing protein"
                     /protein_id="HBH0028833.1"
                     /translation="MKISKRIMSLLTATFFIFALSINIADASSKESLVGSGRWETAIK
                     ISQNGWKDATNAILVNDNSIADALSATPFAKLKDAPILLTQSDKLDSRTKAELKRLGV
                     KNVYLIGGMNTLSTNIEKQLKSENMTFERISGNSRYETSLKLAERLDKEKSISDIVVV
                     NGEKGLADAVSVGSAAAQENMPIILSDPNNGIKVANSFISSKNIKKSYIIGGTYSVSS
                     SIEQSLPNVKRLSGNNRNETNAKVLEEFYKNTDLKNAYITKDGMKKQGDLIDSLAVGV
                     LAAKNSSPVVLVGNSLDSSQYDVLNTKSFDNIVQVGGNGNEDAVKDILDLQEETIYRV
                     KTADELDVALRKADANDIITFKPDDNKKITSSFSIETKKAITVELEGLYTQTITVNMP
                     NGELTNKGTLDGTVKIMDIKNGTFINEGDINDIDIYDPNGCKIENKSGGDIWVLTISS
                     SAKDVNIENKGDISKVTNNSTSVIIRNSGNIDTLSGINAPAISGNKPRVDDTDKDEKR
                     ASGIYPTSEPLSPARAGYISVKIFTKPEDTNYKIYYRVVSSRPSALYIGDRIDTSDWT
                     AVPSSVLPFTIKAENGYYIEAVEINSDTKKVSRWGKSDYIDDGFYLKSETAKGLSADI
                     DFDGDYVKLTATGADSGCTVYYRIVSKKPVSMNVGDKVTISDWDEITTNRVRIEANDV
                     KDKYIELVELDDSTNKVTRWGASDKVVE"
     gene            complement(132245..132640)
                     /locus_tag="KR257_000102"
     CDS             complement(132245..132640)
                     /locus_tag="KR257_000102"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897950.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GtrA family protein"
                     /protein_id="HBH0028834.1"
                     /translation="MILKKHRETILYLFFGAFTTLVNIVSYLFFTRVILFNFMVANAL
                     AWILAVLFAYVTNKFFVFESKRIELIFLFKEFLFFVSFRLLSGIIEMIIMYIMIDLFF
                     VNDITVKVFTNIIVIVLNYLFSKMIIFRK"
     gene            132867..135278
                     /locus_tag="KR257_000103"
     CDS             132867..135278
                     /locus_tag="KR257_000103"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861680.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell wall-binding cysteine protease Cwp84"
                     /protein_id="HBH0028835.1"
                     /translation="MRKYKSKNLSKLLALLTVCFLIVSTIPVSAENHKTLDGVETAEY
                     SESYLQYLEDVKNGDTAKYNGVIPFPHEMEGTTLRNKGRSSLPSAYKSSVAYNPMNLG
                     LTTPAKNQGSLNTCWSFSGMSTLEAYLKLKGYGTYDLSEEHLRWWATGGKYGWNLDDM
                     SGSSNVTAIGYLTAWAGPKLEKDIPYNLKSEAQGATKPSNMDTAPTQFNVTDVVRLNK
                     DKETVKNAIMQYGSVTSGYAHYSTYFNKDETAYNCTNKRAPLNHAVAIVGWDDNYSKD
                     NFASDVKPESNGAWLVKSSWGEFNSMKGFFWISYEDKTLLTDTDNYAMKSVSKPDSDK
                     KMYQLEYAGLSKIMSNKVTAANVFDFSRDSEKLDSVMFETDSVGAKYEVYYAPVVNGV
                     PQNNSMTKLASGTVSYSGYINVPTNSYSLPKGKGAIVVVIDNTANPNREKSTLAYETN
                     IDAYYLYEAKANLGESYILQNNKFEDINTYSEFSPCNFVIKAITKTSSGQATSGESLT
                     GADRYETAVKVSQKGWTSSQNAVLVNGDAIVDALTATPFTAAIDSPILLTGKDNLDSK
                     TKAELQRLGTKKVYLIGGENSLSKNVQTQLSNMGISVERISGSDRYKTSISLAQKLNS
                     IKSVSQVAVANGVNGLADAISVGAAAADNNMPIILTNEKSELQGADEFLNSSKITKSY
                     IIGGTATLSSNLESKLSNPTRLAGSNRNETNAKIIDKFYPSSDLKYAFVVKDGSKSQG
                     DLIDGLAVGALGAKTDSPVVLVGNKLDESQKNVLKSKKIETPIRVGGNGNENAFNELN
                     TLLGK"
     gene            135575..137152
                     /locus_tag="KR257_000104"
     CDS             135575..137152
                     /locus_tag="KR257_000104"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861679.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell wall-binding protein Cwp5"
                     /protein_id="HBH0028836.1"
                     /translation="MKAPKTILTILTIALTLSSISIIPSYALTEEKLIGNGRYETAVK
                     ISQKAYSSSPNVVLVNDNSLADALSATPFAKAKGAPILLTESDKLDDRTEKEIKRLGA
                     KDIYLIGGTAVLNKDIENKLKSNGLNVERINGKDRYETSLILANKLKDIKDIKEVAVV
                     NGEKGLSDAVSVGAPAAQNKMPIILSSPKDGVEAFDKFIRDEKVIKAYVIGGTNSVSR
                     AVEKSLPNAERVSGKDRNETNAKVIEKFYTDTNLSNLYVTKDGSKNENQLIDSLAVGV
                     LAAKNESPVVLVGNKLNTKQRDILSTKKLNTITQVGGNGNEEAFDEIKSLQEKTVFEA
                     KTVEELTDMINIASPNDIINFKPKENTVNEAFRMVTNKPITVNIKGDCSKTLTVDMPN
                     GEVNNYATLVNVIVRNIGEGGFNNHDTITILSVRDKNGRVIENTRNSDIDTLMILASA
                     NDTKLINDGYIGKLIDNSSNSDITNNGTIDKKVNQVEDLEAKVDSIEKAIDSISQKVN
                     KIQDILDKLGFLKKFLS"
BASE COUNT        53432 a        15669 c        23871 g        44387 t
ORIGIN      
        1 attatttatt tctttgtgag ataaattttt tagaataatt atgtattcat cacctccaat
       61 acgataaact atatattttt tatttattac atattgtata attttacttg cttgcttaat
      121 atataagtct cctgtctgat ggccaaattt atcattaatc ttttttaaac cgtctaaatc
      181 tattgatatg atagatatta gattctttag atttgaattg tttaagttat tcatatctat
      241 ttcaaaagca tttctatttt ttaggcctgt taaataatct gtattagcaa aatcagtata
      301 tgtaggatta gatattcttt taaatagaat cactgcaatc aatgctgata ttagacaagt
      361 taataatgct attattggtg taactatact tataaattta aatgtattgt attgatgttt
      421 tgcttcaaat tcaattccta ttactccaac aaccttacca acatcattgt gaataggaaa
      481 atacgatata aatatgtatc cccaagatgt tgatttaatc tttttaggta acaatatatg
      541 attatctaat gctttgttaa ggtctcccca aatctctttt tctatcaaat caccagcatt
      601 tctaaaatca ctcctagatg aatttaaacc atcaacaaca tatactagtg atccatcttt
      661 tgttttttta gcagtatata gatacatgac tccagtagta ttttttacag attctaaaag
      721 gattttagaa cttttataag acttttttga ttggtcttct ttagaattaa tttcagtaaa
      781 ggtattttta tcaatatttc tttctacata ttcatagata tgttttgacc tctcacttaa
      841 agagtatatc atgctcttat aagttagtgt ataattaaaa aaatatacac atgaggaaga
      901 tattattaca ataattgcag taagtattga aacctgcata tcaactctat tgaatttttt
      961 atttattttc atagcttaaa tgtcttgtga aaagaacctc ccacaatctc cccataatta
     1021 atatatatct ataaatttca ccataatata ttcatatatt atcaaatttg tgtggaaatt
     1081 acaattagta aacatgctta aagcattcaa atatagtttt tttattatta tagtatacta
     1141 ttttatgtat aaataaaatt atatataaat cattgatatt ggttgtttat taatggaaga
     1201 taccgtataa aatattctaa ttggttacga tatgtatact taattgaagt taagttaagg
     1261 gttagaatat gtattgatga aatggctaga tttatattca taagtattaa ttttatcata
     1321 gataggtaaa atactgtatc ttaaacataa gtatgattga gatgcaatcc tgagatatga
     1381 taatataaat tgaaggatag tgaactcaat caaataaaat gattaatcta gctatataag
     1441 caaataaatt taatataaaa gaggtggaaa atgaaagaca gacttaattt aacagaagga
     1501 agaattacag aaaaattact taagctatca cttccaataa tggggacttc atttatacag
     1561 atggggtata acatgataga tatgatatgg gttggtaaag ccggaagtaa agcagtagct
     1621 gcagttggaa cagctggttt ttttccatgg cttgcaatgg catttattat gatttcaaaa
     1681 gtaggtggag agataaaagt agcacaaagt attggtgcaa ataatataag cactactaaa
     1741 tcatatatga agtcagcaat agaaataaat attatactag caataatata tacaatttct
     1801 ttaatagtac ttaataaaca attgataggt ttttttagat taggagactt agaagttata
     1861 accatgtcta gacagtattt gataatagta gctctaggta tggtatttta ttttattaat
     1921 ccagtattta ctgcaatttt caatggtctt ggaaatagta aaactccttt tcgtattaat
     1981 acagtaggat taataactaa tattatactt gaccctatat taatttttgg atggggattt
     2041 gctccaaaac ttggtgttgc aggagctgct attgcaactg tatttgctca gatagtagtt
     2101 actacatgtt ttatatatat aatagttaaa agtaaagaag aatattttaa attaagacta
     2161 tttaaagaaa tagagactaa atattataaa gttctgtata aattgggatt acctatagca
     2221 atacaaagtg gtatgtttac agtattctca atgctattag gagtaatagt agcatcatgg
     2281 gggcctgtgg ctgttgcagt acaaaaagta ggctcacaaa tagaagcaat ttcctggatg
     2341 acggctgaag ggctatcagt tgcattaggc agttttgttg gacaaaatta tggtgccaag
     2401 aagtattcta gaataaataa aggttgcaaa atagctataa ctgtatcttc tgtacttggt
     2461 ataataacta ctttagtatt agtgtttgca ggagagagta tattttctat ttttatagat
     2521 gaaagtgagg caatagaaaa aggagcagtt tatcttaaaa tattaggcta ttctcaattt
     2581 tttatgtgtt tagaaataat aacaacagga gctttcaaag gattagggag aacctatata
     2641 ccttctatta taattactat actgactggt gcaagagtac cattggctta ctttatatct
     2701 agaccagaaa tgttgggtct aaatggtgta tggtggagta taaccttatc aagtatatta
     2761 aaaggtatat taatgataag tctatttata tctttattaa aactcggaaa gttgtacaag
     2821 atttctgaat aaaatttaaa ttatcttaaa tgtatagaca ttttctttgt ttgtatataa
     2881 aattatctta ttatataaaa gatttaataa ggagtgaatt aaatgaaaga gccaatttat
     2941 aaagttatag aaaatcatgt tagagagtta ataaattcag acagtttgaa agaaggggat
     3001 ttaatccctt ctgaaaaaca gctgagtgaa gaatttaatg taactagaat gactgtaagg
     3061 tctgcactta ataatctagt taaagaaggc tatataacta gacaaagagg tgtaggtagt
     3121 atagttattg caaataatat atatgataat atatcgtctg taagtggatt tactaaagag
     3181 atggaaagta aaggctataa agtatctaat atattggtat ctcttgaaat agttcaggca
     3241 gatgaaaatt tatcaagtaa gttgaatata agtttagaag aaaatgtttg ggaaataaaa
     3301 agagtaagat tagccaatga tgcaagagtt tcatatatga ttacttatat gccagttaag
     3361 ttatttccaa atttaaataa gactcattgt gaaaattctc tttataattt tgttgaagaa
     3421 gtgtgtgaat acaagatagc catgtcagag agagaagtac aagctgtaat atcgaatgaa
     3481 gagtgtatgg ataatctaaa attagaagaa ccagagccac ttttatatat aagccaaatt
     3541 tgtaagttac aaaatagtga gatttttgag tactcacaca catatcacta tggatataca
     3601 ttaactttga atgctgttgt cgaataaaat ttaaataaaa tgaaaaagtt ttcttgaaat
     3661 gtatatacat ttggtatata ataatatcaa gaattaaatg tatatacatt taaaaataag
     3721 atatatacat taagaaaaaa ttaatagaaa aacatatttt aaatgtatag tttaaaaaac
     3781 ttatgactta aaaaatattt aatgaatcta atttggaggg gaaaaaatga taaaaataat
     3841 gttagcttgt tcagcaggaa tgtcaactag tttattagtt acaaaaatgg aggatgcagc
     3901 aaaggaaaac ggtatagaag caaaaatatg ggctatatca gaagtgaact taaaaaatga
     3961 aatagaaaat tgtgatgtct tacttttagg gcctcaagtt agatatgtat taggaaaagc
     4021 aactgaaatg gcaaaaccat ataatattcc agtagaagtt ataaatatga tggattatgg
     4081 aagatgtaat ggaaaagctg tgttagatag agctgtagag ttaaatagtt caaaataaag
     4141 ttgtactgga ggatgtaaaa tggaaaaatt catgtcattt atggataaat atatagtgcc
     4201 tgtagctgct aaaataggag ctcaaaggca cttagtagca gtaagagatg catttatagt
     4261 aatgatacct ataactatgg taggtgcatt gggaacattg ataaataact taccattgga
     4321 agcatacaaa aatttgatgg caagtatatt tggagaaaac tggaccacat ttggaggcga
     4381 cctttggtgg ggagcaatag gtacaatggc agtattctta gtaataggtg ttgcttattt
     4441 tctagcaaaa tcttatgaga gtgatgggtt acaatctggg cttatagctt tatctatctt
     4501 ttttataatg gctccacaaa ttggtaaaat agttcctgag ggaggaacta cagtagttga
     4561 aggatgggga atgatacaac aaacctactt aggtacagca gctttattct cttctatatt
     4621 aataggatta ttatcaactg agatatttgt aagattatct aaggtaaaga aattaactat
     4681 aaaaatgcca gatggagttc caccagcagt ttcaagatca tttgcaaagt taataccagg
     4741 aatgttaact ataatgatat ttactgtaat aggaatattt ataaaaatgc tttctaatgg
     4801 aagtttctta acagatattt taaatactta tttaggagca ccactatcaa atgtagctga
     4861 tagtctaggt tctacaatgc ttattgcatt tataattcat atactttgga ctgttggact
     4921 tcatggtgca aatatagcac ttccttttac agaaactata cttatgaaat taggtggaga
     4981 aaatgctgcc ttggctcaag caggagcaac ggaaggatac catgtacttg caggtgcatt
     5041 ctttgatgca tttgtatatt taggtggttc tggaatggta ttgggattaa tagtagcttt
     5101 attaatagct ggaagaagac gtaaagagat gatagtatta ggtggtccac ctgcaatatt
     5161 taacatagga gaaccattga tatttggact tccaatagtt ttaaatccta tatttatgat
     5221 tccatttgta cttgcaccag taatatgtag tgctgtatca tacttagcaa tagattttgg
     5281 attagtagca ccagtaattt tacctaaaat accttgggta acacctccta tattaggtgg
     5341 agcaatggct acaggtgact ggactggcgg agctttagca ctatttaatt taatattatc
     5401 aatattaata tatattccat ttgtcatagc gtctgaaaaa atggaagcta ataaattgaa
     5461 aattaacaac taggtagttt tatttcggta aataaatgta tagagtttta aataaatgta
     5521 tggggttttg tagagtatat taaattatag gtaaggatgg tataatgaga tgaaaaaggg
     5581 actaaaaata gttacaattg gaggaggttc aagttatact cctgagcttg tagagggttt
     5641 tataaataga tatgaagagt tacctgtaaa ggaattatgg cttgtagata tagaagctgg
     5701 aaaagaaaaa ttagagatag ttggaaatct agctaagagg atggtaaaaa aagctggagt
     5761 agatatgaaa ataaatctta ctttagatag aagagaagct ctaagagatg cagactttgt
     5821 gacaacacaa cttagagtag gtcttttaga tgcgagaata aaagatgaaa ctattccttt
     5881 atctcatgga gttatggggc aggaaactaa tggtgctgga ggtttattta aagcccttcg
     5941 cacaatacca gttatatttg atataataaa agatgtggaa gaattatgtc caaatgcatg
     6001 gatggtgaat tttacaaatc caacaggaat aataacagag gctgtattca aatatactaa
     6061 ttttagaaga tatataggtc tatgcaacgt gccaattcat ttaaaaaatg atgttgccaa
     6121 actatttaat gtagaaagtg acagaataag tatggatttt gcaggtctta atcatatggt
     6181 ttatggtcta aatgtatctt tagatggaga agatgttaca aaagaagcaa ttgataaatt
     6241 tgtcaaagca gatataagta tgcaaaatat aaaggcaatt gattttaatg ctgaatttgt
     6301 aaaatctttg ggtgcaatac cttgtccata ccatagatac tactataaaa ctaaagaaat
     6361 gcttgaggat gagttgagag agtttaaaga gggaaaagct agaggtcaag tagttaaaga
     6421 attggaagaa caattatttg aattatataa ggatgaaaaa ttagatgtaa aaccacctca
     6481 acttgaaaaa agaggagggg cttactatag tgatgctgct tgtaatttaa taagttctat
     6541 atacaatgac aaaaaagata tccaagtagt taatacatta aataagggtt ctataagaga
     6601 ttttaaagat gaacaagcag tagaagtaag tagtgtaata acaaaaaatg gtccaaaacc
     6661 aataagtata ggatatttac cagattctgt gcatggatta gtaagtcaaa tcaaatcatt
     6721 tgaagtattg gcagctaaag cagctgtata tggcgattat gaatctgctc ttttggcact
     6781 ttgtataaac ccattgattc catctgatga cttagcaaaa actatattag acgaaatgtt
     6841 ggaagctcat aaagattatc ttcctagatt taatagatag ttgtctatag aaagtaggtt
     6901 atggtatgac taaaattata ataaatgcag atgattttgg atattgtgaa gctgtgaact
     6961 atggaataat ttcagctcat aataatggta tagttaggtc tacttctatg atggcaaata
     7021 tgcctggggt agaacatgga gtaggcttac ttaaagaaaa taaaacttta aattgtggag
     7081 ttcatatgac tttaagttgt ggtagaccat tattatctaa cttaaaaact attgttgata
     7141 aagacggttt ttttattagg aggattacag acgaaattat tgaaaaaatg gattgtgatg
     7201 agatttatag agaactttgt gctcaaatag atagggtaaa agggcttgga atagatatat
     7261 ctcatttaga tagtcaccat catatccata ctttagtaag tttaaagcca gtaatagaga
     7321 agattgtaac caagtataat cttccaataa gaggtggatt tgaatataat ttagagtatt
     7381 ctaaagtagt tcctttaata gatagttttt ataaggaaaa tgtaagtgaa gaatatttta
     7441 taaaaaatat agacgaaata atgaagtatg atgtagtgga tattatgtct cacccagctt
     7501 ttttagatga ttatatttta aattctacat cttatgctat tgatagaacg aaagagcaca
     7561 agatacttac atctaaaaaa gtcaaagaat ttttagaaaa gaatggatta gtcatatcaa
     7621 gctatagaga tatttaggag gtcgaataaa tggatgagaa gatgatagag atatcttttg
     7681 gaataattgg atttgcaggt gatgcgaaag ggctagcatt tgaagcaata aaagaagcaa
     7741 agagcgggaa tatagataaa gctagagaat gtattgaaaa gtcgaaagaa tcaattcata
     7801 aagctcataa attccaaaca gaattgatac aaaatgaagc taatggtaat aaaactgaaa
     7861 taagtgttat acttattcat gcacaagacc atttaatgac agctatgaat tttcaacaat
     7921 tagcagaaga atttatagat gtatatgaaa gattagaaag taagtaattt aaaattatta
     7981 ttaaaaaaga gtgtataaaa ataattttta taattattaa atgcactctt tttttattta
     8041 agtagagttt agcaatatag tattatgtta ttgatacttt agaatttaga cttctcataa
     8101 ttgtaaggta tactagtacc aacaactaca tcttcaattt tttcaacaat aagccaatca
     8161 tccatatttc cttgatggtc aaaatcaaga ggtgttattt cttcaacatt ttcaaattca
     8221 actaagcata aacatttttt atgccaacga actttttgct tttcagataa atttaatttt
     8281 ggttgatttt catttaaaat tttagaaatt tcatcttctg ttaatttaac atagttttct
     8341 acctttttaa cagtggcttt tgcagatatt tttgcagttc ctttttccat aaaataaagt
     8401 aactcatctt caaatactct actatgtggt atttttctac cagcagcacc tctaataacc
     8461 attgtttttg ttccatccaa gattttatct aagacctttt ctcctttttt tcctgcatta
     8521 tcacaatata ctaaatgtac catgttttga atcctcccta ctaaattcct tatctataaa
     8581 ttgcatttta tcattgttta actgaaaagt cattgtattt gtgtccaatt cttaaaaaaa
     8641 atactgttta atataagaaa accttatcta agctatatat aattaagatt aattaggaat
     8701 ttttatcctt ttacaaaata atattgacta aaaatagaaa aatgctataa taaatatgtg
     8761 cttatgataa tcaatatcat gtaagtataa taaacaagta ggagaagtaa tcatgaaaaa
     8821 aataaaatca cttgcaatat ttatatctat tataactacg ttagtacttg ttacagcatg
     8881 ttcagataag aatacagagg ataaagataa atcagagaca agagttgtac aatctgttaa
     8941 aggagaggtt aagataccat caaatcctaa aaaaatagtt gatatatcag gaagtagtga
     9001 agaactatta ttagcaggtt ataagcctgt tgcaacagca aatgtagact catatgaaac
     9061 tgataaatta ccaagttaca taagagaaga gcttaaaggt gtaaagatag ttgggcactc
     9121 aatgatggat actatggata tggaagctat attagaagta aatcctgatt taataataat
     9181 gagtcaaaga caagaaaaaa tatatgacca attaaaagaa atagctcctg tagttatgat
     9241 gaaagattat gcaaatgact ggagaagcaa gttaactgat gtttcaaagt tatttgacaa
     9301 agaagaagaa gataaaagtt ggctacagaa gtatgatgaa aaagctacaa agttaggtaa
     9361 ggaagttata gaaaagaatg gagaaaaaac ttatttacca gtgttggcaa gttcaggtca
     9421 atttatggta tttagtgatg gtggaatagg tactctaatc aatgatgata tgaaattagc
     9481 tagacctaag aatatgccaa aacaggatgg aataacacta ccaatggtaa gtatggaagg
     9541 tttaacagat atagatgcag accatatagt tgtaattgct acagaagcag ataaaaaaga
     9601 tttagaaaat agtgctatct gggctcaaat aagagcagta aaagatggta atgtaacaat
     9661 acttgatgct gctccatttt tcagtcaatc atacaatcca attggaaaag agttattatt
     9721 agaatcagtt aaaaatgaat taacaaagta attcttaact tagtaggtgt gagataatga
     9781 tattcatttt tcacacctat ttttaataaa tcttaaaatt aaaatactta atagatgata
     9841 ttatactgac gattaaaagg gaaaaggagg taggataatt gactaagctg agtaaaaaaa
     9901 atataactta tttgttgata ttagtaagta tagttgtact tgtatttgga attgtattat
     9961 ccataactat tggggcaaaa gatatgaatc tatcaactgt tatagatagt ttgataaaaa
    10021 tggaagatgg aataaatatg agaatagtaa aggatgttag acttccaagg gcaatagcag
    10081 ctgcacttgt tggagggttt ttagcagttt ctggggcaat aatgcaagga ataacgagaa
    10141 atcctatagc tgaaccatct gttataggaa ttacacaagg agctacattc gcaatttcga
    10201 tatcactggt acttcaaaaa aaacttcctc aacttataca tggaagtttt agtgtaatga
    10261 tgtttgcatt tattggagca agtataagtg gattatttat atattttata agttctaaat
    10321 caagaggaag agttaataat gtaaaattag ctcttgcagg agtcgctctt ggtacattgc
    10381 taatttcttt ggcatcagca atatctatgt attttaacct atctcaacaa ttaagtttct
    10441 ggatatcagg agggcttgta ggagtgaagt gggaaggtat aaaattgcta tttgtagctg
    10501 gtggtattgg atttatttta gctattatta tggctccaag aataactata ttaagtcttg
    10561 gagaagaagt ggcaatagga ttaggacaaa aaactaagtt tgttagattt atatgtatag
    10621 tacttgtaat attaatgact ggagcatctg tgtcagtgtc tggtaatatt atttttatag
    10681 gtcttatagt tcctcaaata gctaaaggaa tagtaggttc agattataag tatataatac
    10741 cgagctcttt agtattagga gctgtattgc ttgtatatac agatatatta agtaggatga
    10801 taaatcctcc atatgagaca ccagtaggtt ctataacagc acttatagga gtgccaatat
    10861 ttatatacct tgttagaaag ggggagaaat aggtactatg aaaaatatta taaaaataaa
    10921 ttctaaaaca ttacttgtta tatcaatttt aatggtgctt atttttatca cttttttatt
    10981 gagtttaaat atgggctcat tttctataga accaatggat gttataaaga cttttttagg
    11041 gcagggtcag cgtaatcatg aaattgcaat atttaaatta agattaccaa gaatagtaat
    11101 agcacttttg gttggttctg tattatcaac agcaggtgta atacttcaag gagttacaaa
    11161 gaatgattta gctgattctg gaattttggg aataaattca ggtgctgcat tgtttgtagt
    11221 agtttatata taccttatga atggtaatgt atatgaaggt atgagtaact tgactgtatt
    11281 tacaatgcct attgttgcac ttataggagc tttatttgga gcatttctta tatattctct
    11341 tgcatggaaa ggtggtataa attcgtcaag attactactt attggtatag gtgtaaacat
    11401 agcttttact tcaattttga cgatattcca attgaaattt acaacacaag aatttaatag
    11461 ggttatggca tggacatcag gaagcatttg gggaacaagt tggaaatatg taatagctgt
    11521 gcttccattt atagtgattt ttatgggtat aactatttat aaatctaaat atatagatgt
    11581 tttaaatttg ggtgatgaag tatctataag tcttggtgta gatgtagaaa aacaaagaag
    11641 aagacttata atatatgcag taattttatc tggtgtatcg acagcagtag caggtagtat
    11701 ttcattttta ggtttaatag ctccacatat aggtagaaaa ataataggac caaagcataa
    11761 aagattaata ccagtatcag cattgatagg aacattatta cttttaatag cagatactat
    11821 atcaagaaat cttctagcac ctatagaaat accagtaggt atagtagttt ctataatagg
    11881 agtgccgtac tttatttatt taatgttggt aaatgattag gaaagggtgt tgttatgaac
    11941 tgtataaata ctaagaatct aaatgtatca tatggaaaca cagatattat aaaaaattta
    12001 aatttaaata taccaaaagg aaaaataact accatcatag gggctaatgg ttgtggaaaa
    12061 tcgacaatac ttaaaactat aggtagaatt attagcccta atagtgggaa aatatatata
    12121 aatggagagg acatctacaa aaagaagtct aaagaaatag caaaagatat ggctgtactt
    12181 ccacaaagcc ctcaagctcc tagtggtctt accgtttcag aattaatttc ttatggaaga
    12241 tttcctcata aaagtggatt tggtaattct agtaaagaag acagagagat tgtaaattgg
    12301 agtttagaag ttactggaat tgcagaattt aaggatagaa atatggaaga tttatcagga
    12361 ggacaaagac aaagggcatg gatagctatg gctttggcac aagaaactga tatattatta
    12421 ctggatgaac ctacaacata tttagatttg gcacatcaat tggagatact aaaattatta
    12481 gatgaactaa ataaaaaaca aggaagaact attgtcatgg taatacatga acttaataat
    12541 gcagcaagat ttgctgacca catgataggt attaagaaag gtaaaatagt ttgtgaaggt
    12601 gatgcatatg atgttatgac gaaggataat ctaaaagaat tatttaatat tgatgcagaa
    12661 atagcaacag acccaagaac aaataaacca atttgtataa cttatgacat ggtgtaaatg
    12721 gtgacaacat ggagaatcaa gaagcattaa gacatgaaaa aatatggatt ttattattta
    12781 ggtattcgat acctgcaata atagcaatga tggtaacttc actttataat gtagtagata
    12841 gagcttttat tggttctatg gaaggtattg gctctatagc tattgcaggt cttggtgtaa
    12901 ctatgccagt atttactcta ataatagctt ttggaatgtt ggtatcagta ggtgctagca
    12961 caagattgtc tataaagtta ggggaaagaa atagagaaga agcagagaag atattaggta
    13021 atgctttgac attatctata attatctctt taattataac tatattagga ttagttttct
    13081 tagaagagat actttttatt ttgggtgcaa gtaaagattc aatattttat gcaaaagact
    13141 atatgagtgt catattggtt ggaagtatat ttaatttagt tgcattttct cttaataatg
    13201 caattagggc agaaggtaat ccaaaattag cagcaaggac aatgattgta ggatgtgtat
    13261 taaacctgat attggaccct atatttatat ttgtatttaa tttaggtata aaaggagcag
    13321 ctatagcaac agtactctgt caaatagtag tatttttttg ggtaatacat tattttataa
    13381 gagggaagtc caatttaaaa ctaaaaaaat gtaacttaaa attgaataaa gatatagtaa
    13441 agaaggtatt tgcaatagga atgacacctt ttgctatgga agtagctata agtataactc
    13501 acatgtttac aaataattct ctaaaggttt atggtggaga tttagctatt ggagctatga
    13561 cagcacttac atctatttta ttgatgttta tgatgcctgt gtttggattg aatcaaggta
    13621 tgcaaactat aatatcatac aattatggtg caaaacaata tgagcgtgca aagaaaactt
    13681 taatattatc tatcatagtg tcagttgtca tattgtcatt tggattttta gtagtacaag
    13741 ttttcccaga agtatttgta ggtatattta ataaagattc agatttgatg gatatagcag
    13801 taagaggtat aagcctaaat ctaattacat tgcctataat ggggatttct attgtaggac
    13861 ctgtgtattt tcagtgtata agtaaagtta aacattcaat gtttttaact cttttaagac
    13921 aatttatttt atttatacca ttaatcattg tacttccaat tcaatttaat ttagatggtg
    13981 tttggttggc acagccagtt gcagatttta ttgctatgat aatcgtatta ttattcttaa
    14041 aaagggaatt taaaacaagc cgagtgtaag aaatttagaa aataaaatta aattggaaaa
    14101 taaaaagact tgtctttata aaatgattaa aattatttta tagagacaag ttttttattt
    14161 tatttaaacg gaactatcca tactggtttc ttctagtttt tttccaaaag tcattttctc
    14221 aaatatttct tgaggtagag gttttgaaaa aacatatcct tgtatcatat cacaattaat
    14281 ttttttaaga taatccattt gcaagattgt ttcaacacct tctgatatac tattcatatt
    14341 taattttttt gccaaattaa ctatagattc tattacatga ttttcagcaa tattatctgc
    14401 attaggtgag ctaaaaaaag cacggtcaag ttttaatgtg tcaactttta tttcttttaa
    14461 catattgagt gaagagtatc cacttccaaa gtcatctagt gaacattgaa aaccttcttc
    14521 atggatttgg tctattatat taattaattt ttggagattt tcaaatacaa gtgtttcagt
    14581 taattcaatt tctaagagct tagcaggaat gttgtattta ttacgaagca ttctgtattt
    14641 ttctaaaaaa tctatattat ttaaattagc acgtgaaaaa ttaactgaaa caggtattgg
    14701 agtttctcca ttatctatcc attttcttat catactacat actttttcaa aaacatagtg
    14761 gtcgagtttt gtaataaaac catttttttc aaagaaagga ataaactcgt ctggtggtat
    14821 aaggccttta tttgggtctt gccatcttac taatgcttct gcacctacaa tagtattatc
    14881 tttgaggctt attttaggct gaagatatac tataaattcg ttattattta atgcttcctc
    14941 cattctattt tccatttctt tttctttaat catttttaaa cgctctaaat cactataaaa
    15001 aacacatgta taaagtggat gatttccaat gtttccttta ttattttttc gtgcaacatt
    15061 tgcacggtct tgaattgaaa ctaaaggtag atttgggtca tcaattttat atacacctat
    15121 agatagagct ataaaatatt tacattcttc atttttattg aaactattaa tatcattggt
    15181 gatattttct atgtacttaa gaatttcttt ttgaggaata gttttaataa gtacattaaa
    15241 ctggtcatta gaaactcgac aaagcaattc tcctggttct agataattac taatgacatc
    15301 atgtatgtac tttaatgttt tatctcctgc ttcactacca aaagaatcat taataagttt
    15361 gaatttctga atatttatag ataccaatga atagctttct gatgaagatg actgtataat
    15421 ttttttagct tcaatatcaa aacgtgcttt actgtaacct ttagttacag agtctacata
    15481 ggcgattttt ataagttgtg ccctgttttt ttgatttata aacataatca atataataag
    15541 caataaaaat agtataacaa ttaaaatatt gatgaagatt gcttttttta gaagtaaatc
    15601 aaactgtgca cttgctgttt ttgttggaac aattgaaagg aggtataagt tttcttcttg
    15661 taatggaaga tagtgcattg ccttagaaat accatcattt aatgtataat acatagaacc
    15721 agttttgttc ttttttaagt ttattttcat ttcttcaagt ttatttttat caacctgttt
    15781 tccttggtgt ttaatcatgt caaaaaaatt taccacattt tttggagcat ttttgtttgc
    15841 tgaacttaca ataaaatttc catcttggtc gataatttgg gaaaatcctt caccatgaaa
    15901 gctttctaca cttaataaat ttctcatagt atcaatagta ttccaagcag caacagctcc
    15961 aacaatttta tcgccattgt atagtggtac agaatataaa attccatatg taccagattg
    16021 tgatttaaca ggagtaattg tttctttgcc ttgaagggct tttctataaa agtcttgtcc
    16081 tttaacatta cctgtatctt taagggcact tacaaaattt ccattagaat ctataatacc
    16141 taaccaatca aattcaaata attttaattt ttttgataag tatctattga cttctttttc
    16201 actatcatta atctcaaaat aagtatctcc catagaatat agtgtcctaa atatactttt
    16261 acatttcaca ttaattgtag tggaaatacc ttgtgaaact tctacaagat atcgttctgt
    16321 ttcattatgt gttactttat ttagattcat aataaaagtg acacatgtta atgacacgat
    16381 taaaagaagt gtcaatagta aagtagctat tattttttta ttttttgtgt tttcaaagtt
    16441 cattcttttg tttcatcctc catcctttat ttgtttacaa ataagaattc tctcagacat
    16501 attataccaa atatcttttc atacaaagat attaaatttt atttatccca ctttacattt
    16561 agctttattt atgtcttctt agagattaat caagatacgt ttattgttta aatcttattt
    16621 tataatattt tgagtaaaag aggttaaaaa aagaactgtt ttcaaaataa ttttgataca
    16681 gttccttttc agtatagaaa atttttatag tattagaaag aacttttagc ttatgtatct
    16741 acataagtat tatatttata aaagatattt tgttacaatc taaaatgtag atgaaattct
    16801 gtaaatgcca aattctctat gaccaagact ttcagctttg gtatgtttac cattacagac
    16861 ttctattatt tcattaaata tttcttgacc tatatctgct attttagcac catctgttat
    16921 aattctacct gcatttatat cgatattgtc tggcattttg ttgtatgtat cactattccc
    16981 agtgatttta ataactggtg aaatagggct tcctgttgga gtacctctac cagttgaaaa
    17041 gattacaatt tgtgcaccac ctgctaccat accagtgata gaatctatat cttgacctgg
    17101 agtatccata aaatataatc cttttttatc aggaggtaca atatcagcat attcaagagc
    17161 acctttgaat ggcttattgc ctgccttata catacaccca agtgactttt cttcaattgt
    17221 tgaaagtcca ccagttttat tgcctggagt aggttgacca ctacgtaaat cttctcccat
    17281 agcaattgct cttttttcta catcacttac aaatttaaga aacttatctt tcatttcttc
    17341 atcttcaaaa cgggtagcca acaaatgttc tgcaccaatt acttctgtag tttcacttag
    17401 tatgctactt ccaccttcat ctacaagaag gtttgatgca acgcctattg aagggtttga
    17461 agctattcca cttgttgggt cagaaccacc acattcaagt gctaatgtaa tttcactcat
    17521 accaaattca actcttactt cttttgatac ttcacgagcc attttactta ctatttcagc
    17581 tcccttagaa actgttttta atgttccgcc acattcctgt ataacaacgt aatctacctt
    17641 ttttcctgtt gtagctattt cagatgctaa ttcttttgct tgaataccat cacatccaag
    17701 accaactact aaaactgcgg caacattagg attttttcca aatcctatta atgtctttgc
    17761 tgtaagctct atatcagaac caatttgaca acatccatgt tgatgaggga ttgctattgc
    17821 tccaggcaca agtgatgcta ttcttgtagc tgtctcactt gaacatacag atgttggaat
    17881 aattaaaaca tgattacgaa taccaaactg accattttct cttaaataac ccattaattt
    17941 cattttaact tcctcctatt ttttatctcc acgaccacgt gtactttcaa tgttatgtac
    18001 atgaacatag tcaccagttt ttatgtcaac tgttgcaatt cctataattt caccgtattt
    18061 gtatacaaca tcaccttttt ttacatcttc tgtagccatc ttatgaaaga ctggtatatt
    18121 atcatttact atgtaagatt ttccatcaat tgaaactttt tcacctttaa ctaaaggtct
    18181 gacacatgta actagattat ctttttcatt tgcatgaata attgcattca ttaattttac
    18241 ctccttaagt attaatttac ttcaatattt ttatttgttt taaaaataga ttttttcttt
    18301 ttttctcttt tatctagata ggaaactaac attggacaac atattgctgt aacaataata
    18361 gcagcagcaa cctgtactgt tgaaacagct gctattgtag ctagagtagg gtctatagct
    18421 gctaaagctt caggagtacc agctgcattt ccggctgttg tacctgtagc tgcacctact
    18481 gctggatgtt ctgcacgtat aagtttcatt acaaagtacc cacccatacc tgttattata
    18541 gtaactccta aaccaagtac aactccaggt agtccagcag ttataatttg attaaagttt
    18601 aatgctgctc ctaaaggaaa agcgaagaaa ggaattaata atgttgtacc aggtgcaaga
    18661 aattctcgta tatcttcatc aaggttacca agtataaatc caagtagtat tggtataagt
    18721 gctgcaaata gtgctattat aggtacattt gcaagtccag ttactccaaa agcaagcatt
    18781 gtaaaaaaag gaccatcatt tagagataag atagatattg ctccaacatc tgtggagtct
    18841 ccatattcac ctgcaagagc agcaaataga cctccatttg aattagtcat ggtagcaact
    18901 atggcaagag gtgtaatacc aattatacct ttaggtccaa taaatttact aacaataata
    18961 cctaatactg caccaattat aaattttgtt gctgtaagta ctataccttt agtcaatggt
    19021 ttaccagctt gtctgatatt gatttgagct ccattgcata gacaaaatag agcaagtata
    19081 ctcattgcac cagttttaaa taaggatgtt gtgaatcctc caatttcaag agcttgtgga
    19141 catactgtat taaatagtgc tcccaataac aagggacaga ccataagtcc tcctggtatc
    19201 tttttcactg attttaagat gtgcatctag tatcactccc tttcattttt atataggtat
    19261 tataaaagca attaatatgc caatatatag agtttgtatc tttagttatc atgattattt
    19321 ttaataatcg attgaaatgc tgtagattac ttataattaa aagtacgatt gacgagaatt
    19381 tcacttacaa agattctttt tatcatataa ttgtattttt tattgaaaac aaataaacgt
    19441 cttatgtatt aaaattaaac ataaaacgtt ttgatatata taggtatgta ttatttttaa
    19501 acatcatctt ctatttcttt taacttacgc catagagtgg agcgagttat ctttagaatt
    19561 tcacaggttt ttgtagtatt tctattattt tcgttataaa ttttatagat atattttttt
    19621 tctaaagttt ttaaatctaa attactgcat tcaaaatcac tattatcttt atcaactata
    19681 ttatttgtat attcattgct aaccttttct aataaaatcg agtcaaatga ttccacaata
    19741 acagcccttt ccatcatacc ttccaattcc cttatattac cttcatattc tcgttcaaga
    19801 agtgcctttt taatatttgg agtgataatt aaaggcgttt tattgtattt gcttgaatat
    19861 ttatgtataa aaaattctga taattttata atatcttctt ttctttcttt taatgaagga
    19921 agatataatg ttagtatatt tattctaaaa taaaggtctt gtctaaataa accattgcgc
    19981 atcatatttt ttaagtcttt atttgaagca cagataattt ttacatctat aggaataact
    20041 ttatcaccac caattctcat aacttgtttt tcctgcaata ccctcaataa tcgaccttga
    20101 agttcaagag ggatttcact tatttcatct aggaagattg taccttcatg tgctagttcg
    20161 aatacacctg ctttaccttt ttttctagca cctgtaaatg aaccttcctc ataaccaaaa
    20221 aactcactct ctattagaga tggaggtatg gcagcacaat ttacagcaac aaaaggtgca
    20281 tttttacgct tactatagtt atgtatactt tgacaaaata gttctttacc aactccagat
    20341 tctccagtaa taatcatagg agtatcataa caagcatatt tttttgcaag ttctatacaa
    20401 tcttttgtct tttcactagc atgaattata tcatcaaaag tgtatttagc agatagacct
    20461 ttgcttaata agctccttct tattgtatgt tcaaaagaac ttatctcctt gctatcttga
    20521 aatgttgaaa cagccccttg aatctgacca tcaacaatga ttggaactct atttgtaata
    20581 atttttgtac tccctatatt ttgtatttca ccaatttgag gttccatagt ctcaactact
    20641 tgtggaagaa ctgtgtttgg gataacatct acaacattat gataaagtgc attttctttt
    20701 tttataccaa atattttttc agcactctta ttaaataatg ttattttaaa atttttatca
    20761 actgttatta ttccatcatg tacaaaatct gtcatagctt ctatctgtaa tcttcttttt
    20821 tgttcatcct tggttgcttc gagtatttgt tctgcttgtt gaatggctct aagtatgttt
    20881 tcttctctag attcgattaa tattccctta caattaagtc tcttaacaat atgtgcaaca
    20941 gtggtatctc ctatatatgt gtttatacct ttctttctgt acttttctat agcatcataa
    21001 atttcttctt ctttttcaat ttcaatcata gttattttct tattcaatat ttcttctata
    21061 atatcgaaac cgtagatgac attattaaat ccaattattc caaatggttc gttggaattt
    21121 tttacctctt tgtaactttt tataatatca taagcatcta ccttaatttc aactataggt
    21181 atattgtaag tagcttttaa catattgtaa gttccacctc ggcttatgat aattctagta
    21241 ccatgattaa tacttttttc agcaagaggt ataccttctt ttagattgcc aaatacaaca
    21301 tcaatatttg tatatttgtt ttttttaact atgtgaattg atttttcata ggttccttta
    21361 gtgggagcaa taacgagtat ttccttcata ataattcctc catatttcat caaataaact
    21421 taaatattat cttatgacta aattttatca gttatatttt aacattttac tttatattta
    21481 attataaata aagtattttt aaaaggaaca ttataaaaga ctgtatcaaa gttaactttt
    21541 agaattataa agtttcatct ttttacagtc ttttaatata taatatctat ttatcaaatc
    21601 tatctacttt aaataatttc atatttttat tttgtttgcc aagatataat tcacttaaca
    21661 ttatacctcc taatattgca aagagtatac catttgctcc ataacctaag caataccata
    21721 gattgttatt tttattatct ggaccaataa aacctaaatt atctaaagtt gaagcaaaac
    21781 aaccacaata tttatattca acttcaatgt cttttatatc cttaaacata cttttcaatc
    21841 tttgttctaa aatatcatac ttttcattgg ctaaagtttc attttctata tcatcaaaac
    21901 ttacatcttc accacctata attaatcgat tgtctttagt agttcttaga taattatatg
    21961 ggtcacagtt atctctaatt aaaatgttgt ttttccaaga agctatgttt ttaagtggtt
    22021 tcgttgctat attaaaagta tttgacttag ttgcaaaatt tctttttgta aataaacttg
    22081 tattgtaccc tgtagctaca attaattttt taccatgaac tttgtatcca tacgatactt
    22141 cagcagtaac cttatcattt gataaatcta ctttttttac ttctgtattt tcatatactt
    22201 gaagaccatt ttttaaactt acatcaatca aatggtgact atatttatat gggtctaatt
    22261 ctcgtcctcc attctttgct atcaatcctg attttaaatc aaagttaaaa gggtttgtgg
    22321 attcatcaat atattcaaca tcaaatccat tttcttttct taagttatat tcttctttga
    22381 tagccttaac ttcaagtttg ttggcagtat aaagtagagt atctcttttg gcataatcac
    22441 acttatttcc atatagctct ataaatgtat ctaattcttc aagtgctgaa gtacaaaggt
    22501 tatatgcttt tagagcatct tttagagtca taacctctgt taaatctatc aaattgtcat
    22561 ctaattcata ctgtaataga gaagttgtca cgctagtgct tccatgtgca atccttcctt
    22621 tttcaagaat gacagacttt atattgtttt tagctagata gtaggcacaa atacatccag
    22681 ttacgccacc accaacaatt ataacatcag tatcaatatc atcagtaagg tatggaaatt
    22741 gtcttggaac tttattaata ttggtaaaaa taggatttcc ttttacatat tcttgattca
    22801 tatacttcac tcctaaaatt tattatgtat gagtgtatta ttttctatag caaataatat
    22861 tatacatttt aattatctag ttatatgggt atgtatagat aaaatgtgat aacattttag
    22921 tataaaacat atgtataata tattcataat taccttattt taagtaatat agtatataat
    22981 gtttgttaac aagtaaaaag attgaataaa agttaattaa aaatttaaag taggaggtaa
    23041 atttatgctt tcaaaaaata tagcttctaa ggtattagaa aaatgtctaa ttactggagg
    23101 agattttgct gagatttttg aagaagacac tataaataat tctattagtt taatagataa
    23161 taaagtagaa aatgcaatag gtggaagaaa ttatggtata ggaataagaa tatttaaagg
    23221 attgaaaagt atatatgctt atacaagtga caattcatta aatagtctgt tggatgtagc
    23281 atacaaagct gctgttgctt taggtaaatt ggaagatgga aaaagtgtaa tattaaatga
    23341 cagtattaaa ataaataaca tacataatat aaaaatttat ccaaattcaa taggaaataa
    23401 agataaagta agtgttatga aggttgcata taagagtgca aaagaattta gtaatgatat
    23461 atctcaagta agtgttagct atttggataa agaccaaaaa atattaattg caaacactga
    23521 aggtatatat gttgaggata gaagaataag aaccagacta gggataagtt caattgcatc
    23581 taagggtaat gaaaatcaaa ctggatttga aggtcctggg ggttgtaaag ggtttgaaat
    23641 atttgaagaa atagacccag aatattatgc aaaagaatca gctagagtag cgcatactat
    23701 gttgcatgct aaaaattgtc ctgcaggtaa tatgatggta gcaatagata atggatttgg
    23761 tggagtaata tttcatgaag cttgtggaca ttctttggaa gctacatcag ttgcaaaggg
    23821 gaactctgta tttgcagata aattaggtca acagattgct tccacaaaga ttacagctat
    23881 agatgatggt acaataccaa actactgggg ttctatgaat atagatgatg aaggaaatcc
    23941 aactcaaaag aatatactga ttgaaaatgg aattttgaag tcttatatga tagataaact
    24001 taatggtaga cgaatgggaa tgaatcctac aggaagttct cgtagacaga actacaaatt
    24061 tgcaccaact tcaaggatga ctaacactta tattgctgct ggagaagata gaccagaaga
    24121 tattataaag tcaataccag atggacttta tgctaaaaaa atgggtggtg gttctgtaaa
    24181 tcctgtaaca ggagagttta attttgcagt ttcagaaggt tacttaataa aaaatggaga
    24241 aatacaagag ccagttagag gtgctagttt aattggaaaa ggtagcgata tacttatgaa
    24301 tatagatatg gttgggaata acgtaaaaca agctcagggg atgtgtggct catcatcagg
    24361 aagtatacca actaatgtag gccaacctat gataagggta aaagaaatta ctgtaggtgg
    24421 aagataggag ggataattgt ggaacttaaa aattttaaag atatattatt taaaaaggct
    24481 ctaagtgaag gttttgaaga gtatgaaata tattattata caggagaaaa tttaagtata
    24541 aatatatatg aaggagaagt tgagaaatac aatcttgata aatcttttgg tttatctttt
    24601 agaggtaagg taaatggaaa gataggttat tcttatacag aaattttaga tgataaagct
    24661 gttgatatgt tgataaaaaa tgtaaaagat ggagtaaaca ctattgaaaa tgaagatgta
    24721 caatttatat atgaaggaga taagcactat aatgatgtaa agacttattc taaagagcta
    24781 gaaaatttag aggcagataa gttgattgat ttagctttag aaatggaaag agagactaaa
    24841 gcttattcag ataaggtggt aaatttatct aaatgtacta tatcttattc tgtatcaagt
    24901 aatggtatat ctaatactaa aggtcttaat ttaagcaata aaactaatat gcttataggg
    24961 tttgtagttc ctatcataga agacaatgga caaaaatatg atggaatagg atataatata
    25021 gcaaattcta ttgaagaaat aaaaccttgt gagatagcaa aacttggtgt tgataatgct
    25081 ttatctaaag taggtggtaa gagtattcca tcaggtaaat ataaaactat attgcttaat
    25141 gaagctatgg tatctttgct tagcacattt tctgggatat ttaatgcaga ttcagctcaa
    25201 aaaggattat ctttattgaa aaatagagaa ggagacatga tagcatctcc tatagttaca
    25261 atagttgatg acccactttt agaaaatggt atggcatcta ctccttttga tgatgaagga
    25321 gtagctacat ttaaaaaaga agttgtttta aatggaaagc ttataacttt acttcataac
    25381 ttaaaaacgg ctaataaggc aggtgtaaag actacaggaa atggaataaa atcttcatat
    25441 tcatcaccta taagcatata tccaactaat ttttatatag agaaaggaga taaatcttta
    25501 gatgaaatta taaaggatat agatgaagga ttgatggtta ctagctttgc aggacttcat
    25561 tcaggtgcaa attcagtaac aggagacttt tctttagctg ccaaaggctt ttatatcaaa
    25621 gaaggaaaaa aagtatttcc agtagagcaa attacagtag caggaaacta ttttgacctg
    25681 ttgaaagata ttgaagctat aggggaagat ttagaatttc caatgagtag tataggttca
    25741 ccttcagttg ttattaaaga gctatcagta gctggaaaag atgaataatt aaaaagtaat
    25801 tttgtggata aaaggtcatg ttaattttaa ttaatatggc tttttattat ttaagtagat
    25861 tttattatct aagttatatg aaaaagtcgt gatgcataca attaatatca tgtattaaat
    25921 ttaaaggagg agatattatg agtgatgcac attatgacat gcacaagcga aatggatatt
    25981 caagtgatga gccatatcca gagataaaag ttttaggtcc aaataagtat tatgcagaat
    26041 tattgatgga tgactatgcc ggagtatcaa gtgaatttac gagtgtaaat caatatctat
    26101 accataattt tgatttagat gaaacgcata gagagttaag tgaaatgtgg ataaatatat
    26161 ctataacaga aatgttacat atggagatat tagcaaagac tataagatta ttgggtggaa
    26221 atcctgtata tagaggttct acaagttctt gtggtgcata ttggaatggt ggttttgtat
    26281 gttatggaaa ttctatttgt aacagattaa aactagattt gcatttggag catgtggcta
    26341 ttaataatta ttataaagat ataagtctta ttgaagaccc ttatataaaa gctatattaa
    26401 atagaataat cctagatgaa aaacttcatg taagtttatt tgaaaaggca atagagaagt
    26461 attgtaaata aatttgaaaa tttagttatt catcatttta ttcatatata taaaataacc
    26521 atcatacatt ttcttgaagg gagttgctgt tgatatgtat tatgtatatg tgaatgatat
    26581 aaacatagca gtatatgatt tgaatccgag tgctaaaaaa actgtacttt ttatacatgg
    26641 ttggccctta ggacataaga tatttgaata tcaaacaaat atattgccaa aactcggata
    26701 tagaacagtt tcaattgatt taagaggttt tggtaaatct gatgcaacat caggaggata
    26761 tacttatagc caattagcag acgatattta taaggtggta catgctattg gattaaaaga
    26821 ctttaccctt gttggttttt caatgggagg agcaatcgta cttaggtata tgagtttatt
    26881 taatggatat ggagtgtcaa aattggtatt agctgcagct gctgcaccat catttgtaca
    26941 aagacctcca gaatttccat atggtatgac acgtgaagat gtaaataaat tgatagcaca
    27001 agcatgtact gatagaccag aaatggtaac cgattttggc gaaaaagtat ttgcatcaaa
    27061 tccaccagaa agctttagaa gatggtttaa tgatattggt tttagtgcat caggtattgg
    27121 cactattgga actgctgtat ctttaagaga tgaagaatta tttaatgatt taaaatgtgt
    27181 aagagtgcct actggtatat ttcatgggaa attagatgaa atatgtccgt atgaatttgc
    27241 agtttttatg aatgaaaaaa tagaagattc aattttatat acttttgagt atagtggtca
    27301 tgctatattc tatgatgagc ttaaactatt taatcagaaa tttttacagt ttttagagga
    27361 atagataaat tttattatca cttagaaaaa gagtaatatt atgtgaaaag atttaagcta
    27421 aattttatga tgttttttac actaaacaaa tagggtttta gaacttgtaa ctaagttctg
    27481 agaccctatt attatatatt cctaaaattt gttataattt attccttgtc attcttaaaa
    27541 atgtattaat atattaacga atttatatta aatttttgtt tatattccaa taatgtcaaa
    27601 ctaaccgttt tagaaattaa attatatgtg aaaaaagata gcttacatta ttttattatg
    27661 gaaaataata gtaaatggta caaaatttga tttttaagat ttaaaacttt tttaaaaagt
    27721 gctacaatag accaaattat tactttctat actcgttaaa caggaggtgg gactatgaaa
    27781 aaacataata ttttatttgt atcaactgat gacaaaataa atatagatat atcaaaacaa
    27841 ttggaaaata tatttggaga attttgtaat atagataact tggtatatgt aaataggata
    27901 aatattgaac tgtcaagcta tgagcttgta gtatgttcag acaatgatat aaaggaatat
    27961 atacataata atattgataa aaatatacct attgtaatag tacatcgtac tataaatatt
    28021 gaaaatataa atcagataat aagtatagaa aatgattctg atgttatggt tatagatgct
    28081 tataaagaat cagcagatga aactgccaag ataattagaa aactaggatt aattcatatt
    28141 aatctaatac catattatcc aggttgtgat aaatctaaat gtgagattgg aattattacg
    28201 ggaagcagaa acagcatacc acaaaacata aagcaaataa ttgacatagg tgataaggta
    28261 attgatataa atacagttat agaaatcttt acaaaactaa atatatctat agataaacta
    28321 catattatta aggaaaaata caatgaagat acagtaagtg gatataggta ttatacaact
    28381 atgaataaaa ccatgaagag ttttttggag attatagatg aaggtattgc ttctgttgat
    28441 aaattaggaa aatttatata ttgcaacaaa gtattttcta atctagttgg aatagaccaa
    28501 aatgaaatta tatctaataa ctttatggac ttatttagtg ataaggttgt caaaaaaata
    28561 ttttttcaag aagatgaagt taatgatgaa gtagtaaatt taaataacaa aaaactgata
    28621 attaataaag taaatgttta tgaaaataat gaacgaataa agagtattat aagcattaaa
    28681 aatataagtg caattcaagt gcttgaggac aagattcaaa ataaacttca gtcaaaaggt
    28741 tttgtatcaa agtatacatt tgagagtgtt gtaggtgaga gtaaaataat aaaagaaaaa
    28801 attaatattg caagaaaaat agcaactaca gacttttctg tgttgatact tggagaaaat
    28861 ggaacaggaa aagaaatatt tgcccaggca atacataatg aatctctaag aaaaaacaag
    28921 ccatttgttg cagttaatct atcttctttg tcagatacac ttattgaaag tgaacttttt
    28981 ggctatgatg aaggaagttt tacaggagca ataaaaggtg gaaaaatggg tatatttgaa
    29041 agagcacata caggaacaat ttttttagat gagataggtg atatatcttt agatgtacag
    29101 cagagattgc taagagtatt acaggaaaaa gaagttatga gaatgggcgg aagtaaaatt
    29161 ataccaatag atgttagaat tatagctgca acaaataaag atttaaagaa aaaaattaaa
    29221 gaaggttctt ttagagaaga tttgtattat aggattaatg tattacatat agagatacct
    29281 agacttagag aacgtaagga agatatacct cttataagta agtatttttt agatgaaata
    29341 aatagcaaca aatgttttac agaggaatca atgcaagctt taacattgta tgaatggcca
    29401 ggaaatgtaa gagagcttaa aaatttaatt tattatattg atactatagt tgaggaagat
    29461 agagtagatt acgagcattt gccagaacaa tttagatttg aaaaaaacaa tactttagtt
    29521 aatgaaaatt tcgattcaat tatcttagat ttcaaacaat ctaatttctt tgaggaaagt
    29581 atatgtatat tgaccagtat agaaacttgg aataataaaa atatattatt aggaagaaat
    29641 aaactgcaag agattttaaa agaaaaagat atagttttaa gtgtagacca aattagaaaa
    29701 agaatagata agttaaagag ccatggttta cttttatctg gagtaaaaaa acaaggtagt
    29761 tttataactg atgaaggaaa gaactttata tcatatgtaa aaattaaggg agtgatatag
    29821 gggactaaaa aggcaaaaca ccctaaaaaa atccctataa tggatagaaa taaataaaat
    29881 tatctttaag attaagataa ttcaaaaata ttgaataaat aatctaagaa gattattttt
    29941 aataaaacag tagtaaatat caaccttact actgttttta ttttttgcaa gatttattat
    30001 acaattaaaa tttatatttt ggcacatcaa ttgctacata ggaaaaatat aaaaaattgt
    30061 agaacttgga ggatgttgtt atgaagtcag cttacaaagg atatgaagcc tatagttatt
    30121 tagaaaaagg aaaagatatt tcatctattg agatgtgtaa aggagataaa agagttaaag
    30181 aataccttat tgaattagat gatattcaag aagctaaggt taaaagtata gtggatgaaa
    30241 aaatatttat atcattacat gaacatccag tattatttcc agaacaccta gaaagagata
    30301 tatttgaata taatagggaa ggtaaacaaa gatgtgctta tgaagcatta tcaagaggat
    30361 attatgatgc tatatttgat aatttaatgg atggtgtatg tacgataaca tcaaattcag
    30421 ggtggaaatg ggatgatata ttaatagatt taggcatgag actatgtgat ttagctcatc
    30481 aagattttgt tataaagtgc gaaaaagtag aagatatata cagagctaaa agtgaaggta
    30541 aagtagcatt gataccaaca ttagaaggtg cagcaccaat agaaaatgaa cttgatagaa
    30601 tagatatact gtatggattt ggtataaggt taatgggtat aacatatagc gaatccaatg
    30661 cattaggttc aggactaaaa gaagagaaag atggaggtct tacaaatttc ggaaaaaaag
    30721 ctgttgaaag aatgaataaa attggaatgg caatagattg ctctcacgtt ggagttcaaa
    30781 ctacacttga tgtaatagaa tatagcaagg acccaataat attaagccat gttggggcaa
    30841 gaagtttatg gaacacaaag agactaactc cagatgaagt attaatagca tgtgctaaaa
    30901 aaggaggggt tataggtgta gaagcagcac ctcatactac aataacagag aagaataaag
    30961 aacattcaat agagtcattt atggaacatt ttgagtatat taaaaattta gtaggaatag
    31021 accatgtagc ttttggacca gatacagtat atggcgacca tgtaaaatta cactcagtac
    31081 tagctgctaa atttgatata aaaaaaataa caggaacaaa agaacatccc aaagtagaat
    31141 atgtaaaagg tcttgagaac ccaacagaaa cttcaaaaaa cattgttaga tatttagtaa
    31201 agcatggata tagtgatgag gaaatagaga aggtactagg tggaaatata cttagagtac
    31261 taaaacaggt ttggaaatag atatattaga aatattaata aaatttgagg atttataggg
    31321 aggttttata aatggattat ttaaaattag ctaatcatcc acttttgtgg atagcgagta
    31381 cagtagcagt atcaatagta gtggtacaat cccttatatt tgctataaaa tcttgcaaag
    31441 ttggtaaaac aatgggaata acagataaac aaataaagtc agctgttaag agtagtgcta
    31501 tttcagctat tgggccttca atgactatat ttgctggaat ggtatcgctt atagtaacta
    31561 tgggtgggcc tatagcatgg atgagattat catttatagg ttctgtaatt tttgaatcaa
    31621 tgtcagccgg atttggaaca gatgcattag gtataacttt aggttctcct gaaatgacaa
    31681 aacttgcatt tacaaatgca gtttggacta tgatattagg ttctttagga tggataatat
    31741 tcacattact atttggacat aaactagata agataaccaa tgttatatct agtggcaaga
    31801 aatcatttat accaataata tctctaggag caatgttggg ttcatttgca tatctaaatg
    31861 ctgatagggt gttgcgtttt gataatggaa caattgcatg tataagtgga atggctataa
    31921 tggtaatatt gtgtatgctt gaaaagaaga aaaatataaa atggttaaga gagtgggggc
    31981 ttacaatatc aatgtttagc ggaatgataa tagcttcagt aatataaggg gggagtttta
    32041 tgagtaaagt aaaatctata tacaatgaag aatatttacc ttttaagata aggtatggaa
    32101 gactaacact atctttgggg attatagcag cattagttcc tggaataatt ttgagctttg
    32161 gatttggtat tatgcctcca atatcagcat tattagcaag tacaatggca attgtcagta
    32221 tgagtgctcc aaattacata atagaaccag tttcttattc accaatctta ggtatcccag
    32281 gaacttatat gagttttctt tctggtaata tatctaatat gaggctacca tgttcaatag
    32341 cagctcaaaa ggcagcagaa gttgaatcag gtacagaaga aggctcgata atatctacaa
    32401 taggaatagc tgtatctatt ttagtgaata taagtatact aactataggg gtaattttag
    32461 gaggaagcgt actatctaaa attccagctg aagtagtaga aaaattaaac ttaattttac
    32521 cagctctatt tgggtcagtt tttggacaag tatttttaca agataaaaaa ttaggcctag
    32581 tagcaattgt aatatctgta ttgactatta tattatcaaa gcaaggtata ataccacagt
    32641 ctctagtagt tcttatatgt gtatttggta ctatgttaat tgcaagagct atgtataaag
    32701 ataagcttag tgactaatta caatgaaata atagtgaatt ttcaaatatg aaatataata
    32761 atttgatttt caaatataaa aattacatta agattattta aaaattggtt tttaaggagg
    32821 gaatattttg atatatgatt taatcttaaa aaatggattt ataataggtg gtacaggtaa
    32881 tcctggtttt tatggagata tagcaattaa agacaactta atagcaaaaa tagattctaa
    32941 gataaatagc aatacaaata aagagattga ttgttgtgga aaagttataa cacctggatt
    33001 tattgaccct catgttcatg aagaaatagt agcaatacta gatggtaaat ttgaaaagtt
    33061 tctaaaacaa ggagttacaa caactataaa tggtaattgt ggacattcta taacaccata
    33121 ttcttctgaa aatgtatatg aatatatgta taaaaatggt ctattacttg aagaagaaaa
    33181 aaagtatctt atagataaaa ataaatgttg gaataatttt acagaatatt gtgaccttat
    33241 atctaaaagt ggtatttctg tcaatatggg attcttgttg gggcatggga ctataagatg
    33301 gagtgttatg ggaggttcta aggatagacc tcctacagaa aaggaaaaaa atgaaattac
    33361 agatataata aatgatggaa tgaaaagtgg tgcttttgga atatctactg gattggcata
    33421 tataccaagt aagtatgctg atattgatga acttgttgat attgcaaagc agattaaaga
    33481 gcatgatggt atatatacat ctcatattag agattacata ggaagatata atgcagtaaa
    33541 agaagccata gaggttgggc aaaaaagtgg tgctagggtt caagtatctc acttaagtcc
    33601 agttgaaata gaagcatttg atgagatatt aaaggctagg tataatggtg ttgaaataat
    33661 ggttgacaca gtaccaagaa gttctgggca ttgtatgaag aaaaaaagag taattcaatt
    33721 tattatggca atatcatcta gtctatttga attaggtata aatggggtaa tggatgctct
    33781 tagaaatgaa gagggaagaa cacttatatt aaaagaagca tttatacttg gagatagggg
    33841 gagtataata cttctaaaca ctaaagatat taatatggaa aagaaatcaa tacgtgaaat
    33901 agctacacaa aaaggaatag atgaagacaa gttattactc gatttacttt tagatggaga
    33961 cgaagaactt atcttttgtt taggaggaat gtatagagct gatttcccag ataaactaca
    34021 tgatgataaa ataattgata atccatttgt tatggttggt tcagattgtt tgtttagtgt
    34081 gggtggggat atgtcatggt ttgaactaca aagaagagga gcttttccaa ttttcttcaa
    34141 tatgtacaga aagtctggtg ttagattgga agagattgta agaagagtta cttcattacc
    34201 agctaggcaa tttaaaataa aaaatagagg tattcttaaa gaagggttga tagctgatat
    34261 agcagttatt gacatggata actatagtta ttctaggtca gaagatattg atttttcaaa
    34321 gccacaatta ctagccaatg gtgttgaata tgtaattgta aatggaaaaa ttgcgttgga
    34381 aaatggagag attactgaga ataaatgtgg tgaagtatta aaaagataag gttttaaaaa
    34441 taataggatt tagaaagtaa ataaatatct aagtaagtaa agacgaagtt tgagatttat
    34501 ttaaataaaa atcatgcttc gtttttattt atagtattaa tatttatttt aataatcaga
    34561 taatatttat actttatagt gaaaaaatta atatttttaa tcattaaatt atgtaaagaa
    34621 ttggataaat agataactaa atcatttgag aaaagatttt tagaaataaa aaatgataac
    34681 taaataaccc ctttaatatt tatcaaatag ccagtcataa atattaaaag gggttattta
    34741 gtttataaaa attatttgta ataaagtagg atatattaat aaatatgata gaatatatat
    34801 tataaattaa atttattaat ataagggggg aactttgagt tcttatagat ttcttacatt
    34861 ataagaacct atactttatg cgggagttat taaaagtaac acttatagta atgcttgttt
    34921 tgataaatgc tttttttgta gcttgtgaat ttgctatggt aaaacttcgt agttctagga
    34981 ttgataccat gataactgaa ggtaataata atgcaaaaag atgtaaaata ataaaagaca
    35041 acttaaattc ctatctttct gcatgtcaac ttggtataac actttgttca cttgcattag
    35101 gttggatggg agaatctaca gttaaagagt taattttacc aatagtaagt gtatttaatc
    35161 ttagtgaaag tattatatat actatatcaa tttccatttc ttttttaatt ataacaatga
    35221 tggaggttgt aataggagag ttggttccta aagctttagc actttataat acagaaaaaa
    35281 taatgttgag tacatctttt ttattagtag gattttataa gttaacatat ccaataatat
    35341 attttttcaa cttaagtact gatttatttc ttaaaccatt tggatattca caagctgatg
    35401 aggttgatga accccataca ggtgacgaaa taagactatt agtagaagaa agttataaaa
    35461 gtggacttat agatgaatca gagcaaagat tagttgataa tatttttgaa tttgaagaaa
    35521 agaaaattag agagataatg gttcctagaa ctgatatggt atgtatatat gaaagtgatt
    35581 ctgaagaaaa gatattagct attttaaaag aggaaggtgt tacaagatat ccagtatgca
    35641 gaaaaaataa agatgatata ttaggttttg tacatataag agatttatac aatcaaaaga
    35701 taaatgaaaa taaaattgaa ctagaagaaa tattgagaga tattatatat atatctgaaa
    35761 atttaactat agataaagct cttgagagaa taagaaagga aaaacttcaa cttgctatag
    35821 ttgtggatga atatggtggt acatctggtg tggtaacaat agaagatata ctagaagaga
    35881 tagttggaga aattcaagat gaatttgata aagaagagac tcatattaag aaaataggag
    35941 caggttctta cttagttgat ggaactgaat ctatcaacta tattaataag tattttggac
    36001 ttgatataga gcatgatgga tttgacagta taggtggatg gatatcctat atgcttggtt
    36061 caaatattaa agtaaaccaa agtgtaactt ttgaaaatta caattttaca atattagaat
    36121 tggataaatt gagggttgta aaattaatca taaaaagtgt aatataatta tatcaaaaaa
    36181 tattggagga attgtatgca aaaagtagaa ggaattattt ttgacatgga tggagttttg
    36241 tttgactcag agagaatttc tcttgaattt tggatggaga cgtttgaaaa gtatggatat
    36301 actatgacta aggaaattta tacatcagtt atgggaagaa atcgtaaagg aataatagaa
    36361 ggtcttacag atatatacga tagttctgta ccaataatag atttatatga cgaaaaaact
    36421 aaaaatatga ttgaatttat ggagaggaag ggagctccta tcaaattagg agtcaatgaa
    36481 ctaatctctt ttttaaagga aaatggatac aaaatggctg ttgcaacatc aacaaagaga
    36541 gaaagagcag taaagagatt agctaaggca aatttaaaag attactttga tgctatagtt
    36601 tgtggagatg atgttgtaaa ctcgaaacca aaccctgaga tattcctaaa agcagctaaa
    36661 aagataaatg ttaatcccaa aaattgtatt gtcatagagg attcgcctat gggagttgaa
    36721 gctgcataca atggtggtat aagatgtata aatgtaccag atttaaaaga gccagatgag
    36781 caaattaaat cacaatcaca taagatactt gaaaatttac tggaagttag agaataccta
    36841 aaaagtttga actctaaaga atgtcacaat ctataatata aagtattaat taaataaatt
    36901 aaatataatt tctttgattt agaataaatc catgaatatg agaaaaaata agtataaaca
    36961 gctaggagga atattcatgg ataatgtagg ttctctatta tattttttat ttaatttttt
    37021 cttgtatggt tttataggtt ggataattga aaacttatat agttattata aacaagggca
    37081 ttttcaagaa gatggatttt taaatggtcc atttaaacca atgtatgcaa ttgcaatgtc
    37141 gattataata gaggtctcaa gatttattga ccccaataat atatttgcat tgcttttatt
    37201 atgtctagta gtgccgacag tagtagaata tattacagga atacttatga aagtatattt
    37261 taataaggtc tattgggatt attcagatta taagtacaat agtagaggaa tagtatgtct
    37321 aaagttttct gtatattgga ctatattgac atttattgga gttagatatt ttcaagtgta
    37381 tatagttgat agtttatata gtcttataat accttattgg ccaattgttg taactatact
    37441 tttagtaaca ttgtttgtgg atgaaattct tactataaaa tttttgaggg gaaataaaga
    37501 tatagtagaa agataacttt aaaaatataa gttgaattta gattgtagtt aaaagaaagc
    37561 tatgttaaaa tggtgaaatc atttaaaatt agctttcttt tttatttgat aaaattattt
    37621 tataatatat ctataagttg taaagttttt tattaaaatt aaaataaagt gtagaaaatg
    37681 gggagtgatt tatgatgggt aaaataagat ttggtattgt tgggacaagc aatatagcaa
    37741 atatatttct aagagctgca tctagggtta aagactttga attggttgct gtatattcta
    37801 gaaatttaga aaaagctaga gaatttggaa ctctatatgg agcaagtatt ttttttgatg
    37861 atttagaaca aatggctaaa tcgaaggata tagatgctgt atacatagct tctccaaatg
    37921 cattacattc aaagcaaacc attacttgtt taaaacacaa aaaacatgtg ctttgtgaaa
    37981 agtcgttagc atctaattta aaagaagtca aatcaatgat aaaaacagcc aaagataata
    38041 atgtattgct tatggaagct atgagaatta catgtgttcc aaactttaaa gcagttaaag
    38101 aaaacttgta taaaataggg aaaataagaa gattttttgg aagctattgt cagtattctt
    38161 caagatatga taaatataaa aatggaatta tagaaaatgc ctttaaaaaa gagttgtcaa
    38221 atggagcttt aatggatata ggagtgtatt gtatacatcc tatggtgaat ttatttggtg
    38281 ctccaaaaac tgtaaaggca gtttctcata tacttcaaac tggagtggat ggagaaggtt
    38341 cagctgtatt tcaatatgat gatatggatg cgataattca gtattctaaa gtagctgatt
    38401 cttatatacc atctgaaata cagggagaag agggaagtat aataattgaa aagcttaatc
    38461 tatttgaaaa agctattatt aaatacagag atggaagaga agaagatata tctattccaa
    38521 aagaaaaagc agaggaaaag cctagagaaa tagaaggaat gtattatgaa cttgtagagt
    38581 ttataagtct tataaataac aataaaatag aatcaaatat aaattctcat gaaaattcaa
    38641 taatagtaat ggaaattatg gatgagataa gaagacaaag tagtattgtt tatccagctg
    38701 atagtatata gtttatatta gaaaatataa gaatttataa tatatattct taaataaatt
    38761 taattttaag ttaaggtaag gtgtatactt aaccaagtgt taaaatgtca aattataagt
    38821 atgaaaaagt gctaaaaaga aatttatttt tggcgttttt ttcttttttt ttacaatttt
    38881 gtaacagtat caaaaaaagt tttgacgatt ttattacaat tttgtagttg aatatacata
    38941 tcaaaactaa tatgattaat aataacataa atttgaatat ttttagagga gagaaaatat
    39001 gagaaaattg atatacttta ttacaccttt tataataggc gtagtatttt tatttgggtt
    39061 agacaaattt cttgattcta aaactgatga acttttgagg gagaaaaatc tacttccaat
    39121 tatggatgat actttaagtg atataaaaga taaaggggtt acagcaaata atcatttttt
    39181 aagagaaaag gatattatga ttttggggtc atcagaactt agtaattcaa caaaacaaca
    39241 tccaaagtac tattttaata caaataggag taaaaataag gtgtttgcaa ttgggagagc
    39301 ctatactcag acattacaag atgctgcaat attaggaagt atgaatccta atattgataa
    39361 taagaaagtt gtcttgttaa tttctatgca atggtttatg gaaaaagacg gagtcacaag
    39421 tcaccattat cagtctagat tttcaccaat acaattttat cgatttttag ataatccaaa
    39481 aatatctaaa caaaataaga ttgaatatgc aaaaaaatca agtaagttat tatggggaag
    39541 tgacgagtat aaagcagaag cattatatgc taagctatat gagcctaaga catttcctga
    39601 aaaagctgaa aaggtgcttt tagagcctta ttttcaagga agaaagtatt gtatagctct
    39661 taaagaaaag ggtattcttt ataaacgatt aattaagcta gataaaaaga gagcaacaaa
    39721 aagaaaaaga ccaataaatt ggtcatatga gagaaagaaa gccattgaag atgctaaaaa
    39781 aagagttggt aaaaatccac taaatattga taagtactat tataaagagc attttaaaga
    39841 tggtatagag caatacaaag gaagagacaa agatgtaaat ttattaacat ctaaggagtt
    39901 tgaaaattat aaactgatgc taaatgtatg tactgactta ggtattaagc cagttgttgt
    39961 attaatccca agtatggata aattctataa tttgactggt atttctgaaa aagaaagaaa
    40021 tcagtactac gataaagcac aaaaaatagc agaaagcaaa ggctttgaag ttctaaacct
    40081 taaagataaa gggtcagata agtattattt aagggatgta atgcatcttg gtacgaaagg
    40141 atgggtagat gtctgtgaga gattatttaa aatatttaaa gaacaataaa gatttgttaa
    40201 ctagtatttg tttaactatg gttataatat tggcgatagg agttctaaca tttactccat
    40261 ttaaagaatt gccatttatt tataacggat tttaaaggag cattcttata tgaaaattat
    40321 tgaaggaata aaaaaatatt caaatacaga tagaacagca ctaatgtgta atggagataa
    40381 actttcttat aaagatttaa atgaatattc agatgctata tcagtatttc taaaggatgt
    40441 atacaaagaa gaagatactc ctatagtaat ttatggaaat aaagaaaaca tgataatggc
    40501 atgtatgata ggagctttaa aatcaggtag agcgtatgtg cctcttgata ttagttttcc
    40561 aattgataga gtttttgaag tcactaaaga gataaaacca aaggtattat ttaactttag
    40621 tgatgaaaga aattttggag atatcaatgt aattgatatg gataaattaa attatataat
    40681 aaatgaatat cagggaaaat cattagataa agaaaactgg gtaaaagatg atgaaaatgc
    40741 atatatacta tttacttcag gaagtacagg aaagccaaaa ggggttcaaa taagttcaaa
    40801 caatttagat agcttttcag attggataag cccatatcta aacatagatg gaagtgaaaa
    40861 agtaataatg aaccaaccag catattcttt tgacctttca gttacaacaa tataccctgg
    40921 tcttatccat ggagctacat tattttcaat atcaaaagat gtattagcag actataaaga
    40981 actatttaga caatttagta tctcagatat agctgtatgg gtgtcaactc cttcttttgc
    41041 aggagtatgt ataactgaaa aagagtttaa tagtaaaatg cttcctaacc ttgagtcaat
    41101 gatattcata ggagaagcac tttcaaaaaa tcttactaaa gaacttatga gtagatttcc
    41161 aaacacaaga attatcaatg gatatggacc aaccgaggct actgttggtg taagtgtaaa
    41221 tgatatgact caaaaggcta tagatgatga aaaaagtctt ccagttggat accctatgtc
    41281 aaattgtaaa ataaaaatac ttgatgaaga tggaaatgag cttaaagaaa atgaaaaggg
    41341 tgaaattata ataattggac catcagtttc taaaggttac ttcaataata aagaaaagac
    41401 tgatgaagta tttttctatg atgaaataga tggtgtaaag tggagagctt ataaaactgg
    41461 agatatggga tatcttttag atggaaatat atattattgt ggaagaaaag attttcagat
    41521 taaattaaat ggatttagaa ttgaaataga agatatagaa aataatttga gaaaagtaca
    41581 taatgtaaaa aatgcagtag ttttaccagt atataaggac gaaaaaattg cttacttaaa
    41641 aggtattgtt gagttaaatg aaaagaatga tttaagtaat attaaaaatg ggatgataat
    41701 aaaaaaggaa cttggaaagt atataccttc atatatgatt ccaagaaata tttcaataat
    41761 ctctgagttt ccaacaaata tcaatggtaa aatagacaga aagaaactta tggaggaaat
    41821 ttaatgattt tttcacaata tggagattat ttttatcttt atatattatt attaacatca
    41881 ataccagcag taattttagg tctaatgggc aagaatataa agtattatgg tatgttggca
    41941 agtttgttta tgatattctt aatagtagga attgatgtcc aactaaagta cttggtaata
    42001 tttattattc ttgaagtaat aatagttaaa ggatatgaat atgtaagaag aaaaactaaa
    42061 aataaataca tatattgggg attcttgttt gcatcaatgc tcccaataat aataaataaa
    42121 atatctccag ttacttcttt tggaataatt ggatttattg gaatatcata cttaaatttc
    42181 agaactatac aaatggttat tgaaatttat gatggagcta taaaagaagt taaaatttca
    42241 aagatgcttt attttatgtt attttttcca actttaagtt ctggacctat tgataggtca
    42301 agaagatttg aacaggactt ggaaaaacaa atctctagaa aagagtatat agaagaatac
    42361 ttactgccag gaataaaaaa tattgtcatg ggagtaggtt ataagtttgt tatagcattt
    42421 ttgataaata catattgggt atcaagaata cctaaagata tgagttttat aaatatttta
    42481 agttatatgt acgcatatag tttatacctg ttctttgatt ttgcaggata tagtttattt
    42541 gctataggta cagggtacat atttggaata caagtaccta taaactttga caagccattt
    42601 atcagcaaag atatgaaaga gttctggaca agatggcata taagtctttc aagatggttt
    42661 ggagattata ttttttctag atttgttatg tcatcaatga gaaagaaaag atttaagaaa
    42721 aggactactg ctgctcatgt ggctcagatg ataaccatga taacaatggg attttggcat
    42781 ggtctaactt ggtattatgt tgcttatggt gtataccaag gattggcact tgtgttaact
    42841 gatatatatc agcgaaaatc taaattttat aaaaaacata aaaaagataa atggttcgag
    42901 agagtgcaga ttttcattac attccatatt gtgtgttttg gattgctgat attctcaggt
    42961 tatttagctt aattttaagg aggaaaattt atgcaagaaa cagttataga aatatttgaa
    43021 gatgtattag ggactgatga gataagagaa gatttagacc ttaatttatt tgagacggaa
    43081 cttttagact cattagctat aattgaagtt ttacttgaaa ttgaaaatag attagggata
    43141 gagcttcaac caactgattt agagagaaaa gatatgtcta ctgtaaataa tttagtaaaa
    43201 ttcttggaga caagaaaata aattagtagt tagactttaa atattaattt ataaaataaa
    43261 attttacaaa gtccatctga tactaatatt tgatggactt ttttaatgat aatacaaagt
    43321 cttttgaaaa taactttaat taagtaaaaa atttaataca taaatatgat ttcataaatc
    43381 ttaggtatca ttgtaatatt ataggagaaa aatatattat atttaggagg aaaatgaatg
    43441 tctttaaatt cgatagatag aaaaaaagaa atacttaaat tactagattc aaaagggaag
    43501 gtaaacacta aagaattagt aaaaagatta gaagtatcat cagaaacaat aagaagatat
    43561 ttggaagaat tagaaaatga aaataaatta aaaaaggtat atggtggtgc tataaaaata
    43621 aattatggag tgattgaacc agaacatata aagagaaaca atactaacct agataaaaag
    43681 caaagtattg ctaaatatgc agctaagttt gtaaatgaca atgagtcaat tatcatagat
    43741 gaaggtacta ccaatttgca gattgtagat tatataatat ctgtaaacaa tttaaaaatt
    43801 attacaaact cttatccagt tctgtcaaaa ttgatttctt acgagaatca aggtttgttt
    43861 gatggagaag ttatatttat tggtggaaaa gtaaatttaa aacaccaaag gacagcatgt
    43921 ccaatatcaa tagatgctat gaaaaactta tacgtagata aagcttttat atctagtgaa
    43981 ggtatacttg atagttttgg aattagtagt atagaccaaa ataaggcatt gttgtcaaaa
    44041 gcatatataa aaaattcaaa ggaaagtttt gtattatgtg atagttctaa aataggaatt
    44101 gctagtatgt ataagatagc agatttagag gaattagatt ttgttatttg tgatgtagaa
    44161 cctccgaatg aatggaagga taagttaaat gagataaata taacatggat agaagcaaaa
    44221 taaaccctta gttttatata atacaactat gctcaataca actaaattca taaaatatag
    44281 tcagttcata gattaagatt agaaagtaaa ttttagattg taacttagga ttttatggga
    44341 atatgataca aaataaaaac aactaaatac aactaaaaac agaaatttaa tatatattta
    44401 acctaaatat gatgtataat taacatatga aagttatact ttaaaagtaa aaacaattaa
    44461 aaacacaaaa attctaaaaa gaatctatgg aggctataaa tatgaaaaag atatatggag
    44521 aaaaaataaa agcagtagta ttcgattggg ctggaacaac agtagattat ggatgttttg
    44581 cacctcttaa tgtatttata gagatattta aaagaagagg tatagatgta acaatggaag
    44641 aagcaagaaa acctatggga aaattaaaaa tagaccatat aagagaaatg tgtgaaatgg
    44701 atagaataaa gaatatttgg tcagataagt ttggtaaagt gccaactgaa gatgatgtaa
    44761 atgaacttta tgctgaattt gagccaatgt tatttgagac attagaagag tatacgactc
    44821 caattcctca tgttgttgaa actattgaaa agttgagaaa aaatggatta aaaataggtt
    44881 ctacaacggg ttatacaaga gagatgatga acatagttga accaaatgca gcaaagaaag
    44941 gatactcacc cgattttctt gtaacaccat cagaagtatc tcaaggaaga ccatatcctt
    45001 ggatgtgcta taaaaatgct gaagctttag gggtgtctcc tatgagttct atggtaaaag
    45061 taggagatac aataagtgat gtaaaagaag gcgtaaatgc aggaatgtgg agtgttgctg
    45121 taataaaagg ttcaagtgag ttagggctta cacaagaaga agtagagaac atggataagg
    45181 aagaattaaa agctaagatg agtatagttt caaagaaatt taaagaggca ggagcacatt
    45241 ttgtaataga aactatggct gagttagaag atatactaat aaaaatagag aatgaaacta
    45301 ttaaatcaga ttttgtacca gaaaatgatt acatattact tacaccagga ccactatcta
    45361 ctactaaatc agtaagagca tctatgttaa aagattggtg tacttgggat gttgaatata
    45421 ataacctagt acaagatgtt agaagaagat tagtatctct agcaacccaa aatacagata
    45481 aatacacaag tgtattaatg caaggaagtg ggactttttc agtagaagct ataataggaa
    45541 gtactatttc aaaagatggt aaacttcttg taattgcaaa tggagcatac ggaaagagaa
    45601 tgaaagatat atgtaattat cttaacatac aatttgttga ctgcactttt aaagatatag
    45661 aagcagtgga tttaaatgta gtagaaaatt tattaaaaga aaacaaggat ataacacata
    45721 tatcaatggt tcactgtgaa actactacag gtagattaaa tcctatacaa gaggtaggga
    45781 aacttgcaaa agaatataac aaaatttata tagttgatgc tatgagtagt tttgggggaa
    45841 ttgagattga tgttgaagat tttaatatag attttttagt tagtagttct aacaaatgta
    45901 tacaaggagt acctggattt ggttttataa tagctaataa agagaaatta tctaaatgta
    45961 aaggtatagc taaatcatta tctcttgatg tgtatgcgca atgggagact atggagaaaa
    46021 ataatggtaa atggagattt acctcaccta cacatgttgt aagagctttt tatcaagctt
    46081 tattagaatt ggaagaagaa ggttctgttg aaaaaagata tgctagatat aaagaaaatc
    46141 agtttacaat agcttcaaga ttaaaatctt taggatttga tactttggtg aatgataatg
    46201 ctcaatcacc tgtaataaca actttcttat atcctaaaaa tgcaaagttt gaatttatgg
    46261 aattttatac ttatttaaaa gataatggat ttgttatcta tccaggtaaa ttgactgata
    46321 tagatacatt tagaataggt agcataggtg aagtttatcc aactgatatg gagagactag
    46381 ctgatgtaat agaaaaattt atcaatagat agaagaagat agtgtcttgt aggttacaga
    46441 atagtgtgga aagcccactc ctttaggtgt gtgagatgat agcacaaaca gtgtataaaa
    46501 agtattgaca gtagaattta aagacttata ttttagaagt ttatacaatg aatatataaa
    46561 gattgagtaa tagggatata ttttatttaa accacaatct aagaaattag atttatagtt
    46621 taaataaagc atttccctat tatttttatg cctatttata gaaaataaat gatagttgct
    46681 ttattaagta ttattatcat acttgacaac gtaacaatgt tttgttatat taggtttaaa
    46741 gataaaatac ggtaaagaaa ggatatcatt atgaatgaag aattaagttc actaagattt
    46801 gatggtgttg gaaaatgtaa aggtggaatt tttgataatg ttaatatatc aggaacaggc
    46861 aaaatagaag gaagtgtaaa atgtagtaaa tttgattctt ctggttcagc aaaagttttt
    46921 gggacaacag aatgtaatga attttttaca tctggtttaa gtaaagtaga aggaaacata
    46981 ctggcatcaa aagttgagat atcgggactt cttagatgta caggaaatat taattctgtt
    47041 gaaattgata ctagtggaat tattaatgta gaaggaagta taaaatctga tattattcat
    47101 ggagaaggat atttaaaagc aaatgagaat atagattgtg aaaatatcaa tttaagtgga
    47161 atcttggagt gtaatggatt tttgaattgt gaagaagtta atattagttt aaatggaact
    47221 tctaatttta atgaagttgg agcaagtagt ataaatataa aaaaggggca tggagattat
    47281 tgcaaaaaat ttcgtatgct agaaaaaaag catatcaact ttgaaaaagt gtcttcaaat
    47341 ttgataagtt taggtctatt atcaattaga aagtatacag aaagtaaatt gtttgcaaat
    47401 attatagaag cagatgaaat aagcttagaa aatagtgaag tcaaagttgt aagaggaaaa
    47461 aatattaaaa taggcaaggg atgttatgta gaaagtttgg agtacagtga aagtatagag
    47521 attgatgaag attcaatagt tggtgaaata aagaatataa gtgaaaaaat aaaattaaag
    47581 aaggataagt aataagtagg tttaaaaata aaatttaaaa tgaggtaata atatggaaaa
    47641 agggtctata aaaatacttg gagaaggctt tataagtagt ggtgagtatg aaaatataaa
    47701 aatcgtggga agctctaaat caaaaggaaa tgttaaaagt aacgaagtaa aagttcttgg
    47761 agatgcaaaa tttgaaggtg acatcaatat aaaaaatttt gttgttaacg gaaaaactat
    47821 tataagaggc aatcttaaag cagagcgtgt aagagtgaat ggtcaactta atatagaggg
    47881 agatgcagaa atagatgact tagttataac tgctcaacag aaagtggatg gcaaacttaa
    47941 atgtaataat gttacaataa gaggacaatt aagtgtaaat gaaaatatgt atgcacaaga
    48001 tataaaaatc tatggcgaaa tgagaaataa atcaaatata gaatgtgaag atataaaggt
    48061 atatggagca ataaaatgtg atggtctttt aaatggagaa aatatatatg tttattcagg
    48121 aggaggttct tattgtaaag agataggggc aactaatata aaaataggaa gaagcaaaga
    48181 tgctttttca ttaattaaaa tcattaatat tttttcagga aagtttaaat gtaatttgat
    48241 agagggagat actattgaat tagaagatgc atcaataaaa gatatacgag gtaaaagcat
    48301 atctctagta gataattgtg atgttggaaa tattgaatac agtgataatt tatcagtttc
    48361 agataattct actgtaaaaa acagtataaa ggtgggctag aaaagttatg gaagaattaa
    48421 tatctaagaa agatttattg agcaaaacta atatatctta tggtcaatta tatagatgga
    48481 aaagaaaaaa cataatacca gaggaatggt ttataaaaaa atcagctttt acaggtcaag
    48541 agactttctt tccaagagat aaaatactag aaagaataga gttaatattg tctatgaaag
    48601 aagagacttc tcttgatgat attgcaaata tgtttatgaa aaaggatatt aataaagaat
    48661 ttgacattga ttttattctc agtaaagaag ttatatgtaa ttataccaaa gaaatatttc
    48721 aaaatttata taaaaaagag caaagcatag gtaaaaaaga actgcttata ttgagcataa
    48781 tagagaagtt tttagttaaa tctataataa cttttgaaga gttaaaattg atagtgaata
    48841 taatagaaga aaattttaca tcaatataca atgaaagtgg aaagatttat ttgtttagaa
    48901 agtttggagt tccattcgta gtaggatgtc tggattataa aaaagtaaag tttgaaaaag
    48961 atgtagttaa gattattgag attgacttga caaaagaaat aaatgatata agtataaagt
    49021 tatcatagtg tattatctta tataatgtat tataataata tacttaaaat acactttatt
    49081 taaatattta gtttaaagat aagattttat gtgagtatgt aaaagttaaa gatagattta
    49141 agtaggttat agggattagt aaacaataaa atgaaccatg atgaattact ataaattgta
    49201 tttaaactac attttctact tatagtaata tcaatggttc attttattgt tattaagata
    49261 atacagtatt tataaaaata cttgatataa atatagtaaa ttgtttaaat agaattattg
    49321 ccttaattta ttcaaataat gagtttttaa aatctaagaa atatccttgt ggatgaagac
    49381 atacaggaca agcttttgga gcttctttac ctatatgtat atggccacaa tgtgtacata
    49441 tccattgtat atcttcattt cttctgaata aagtaccttc ttctaaatca gtagcatatc
    49501 taccaaatct atcaccatga actttttcta tttcagctat attttcaaat aacttagcta
    49561 tagattcaaa tccttcttca cgtgctgttt ttccaaagtt tttatataca tcatcccact
    49621 cttgaagctc attatgttgt gcagctttaa ggtgttgtgc tgtcttgtca tataaatcta
    49681 cagggtatgc tcctgatata cttatatttt caccagcaaa ttcttttaat ttagaaaaga
    49741 attgttttgc atgtgatttt tcttggtcag cagtgtaatt aaataaagac tctattatat
    49801 ataatccttc tttttttgct acagatgcag aaatattgta tctatttcta gcttgactct
    49861 cacctgcaaa agctcttaat aaattttctt tagttttact atcttttaaa ttcatattct
    49921 acctctctat cacaataaat ttttacaata tttgattctt tttatttatt attccaatag
    49981 gagatataat tatgctcaat ttagtcagca tttttaaaat tatcattaat tttttttaaa
    50041 attctaagaa attcttgttt ctcattttct gtaatattat gatatgccgt ctctttaact
    50101 tgtgttgaga tgctattaaa agtatcttct ataagcagtg ccttttttgt aagctttata
    50161 tacgtgatac gtttgtcatt tgtacatttt tgtctttcta aatatcctag gtttataagt
    50221 ttattaacca acactgtaac agtggattta tcttttccta ttttagctgc aatttctttc
    50281 attgtaagta ttccattatt ttcataaagt gcagttaaaa tatttccatg agtaggtatt
    50341 aactcaccta aaccattttt actgagttta ttttcaatga atttaatcat actagccttt
    50401 gttttactta tgaaatgtac aatatattta tcttccataa attattctcc aatctttaat
    50461 ctatttaaat tagtttgaca taaaactatt tataaactat aattagttta acataaaact
    50521 aaatgtattg ggaggaaatt tatgaataaa aaatttaaat cactatatat tacagaagaa
    50581 gaaggaaatt ttagaagaaa tatagttgaa agagaagtgg atacattgcc agaaggcgaa
    50641 gttttaataa aagtaaaata ttcttcttta aattacaagg atgcactttc tgcaaatggt
    50701 aataagggtg ttacgagaaa gtatcctcat acaccaggaa ttgatgcatc tggtatagta
    50761 gaatctagta gttgtgatga ttttaaaatt ggagaagaag ttttagtaac aggttatgac
    50821 ttgggaatga atacttctgg tggtttttca gaatacataa gagttccttc tagttgggta
    50881 gttaaacttc ctaaaaatct ttcactaaaa gaagcaatgg attatggtac agcagggttt
    50941 acagcagctt tatctgtgta taaatttata gattctgtag acaagaatat gggagatgta
    51001 ttagtcactg gtggtactgg aggagttgct gtaattgcaa ctaaaatatt gattaaatta
    51061 ggttattcag ttgtagtttc aacaggaaaa ttagaagaac aaaaagaagt attactaaac
    51121 ttaggtgtta aagatgttat acataggtca gaagtggatg ataactcagg aagacctctg
    51181 cttagaccaa gatgggctgg agtaatagat acagtaggag gaaatactct agcaacagca
    51241 ataaagacaa ctaattattg tggagcagta acaacttgtg gtaatgcagg aggagttgat
    51301 tttacaagtt cagtatatcc atttatctta aagggaatta ctttatatgg tatagattct
    51361 gtggattgcc caatgaactt aagattaaaa atatgggatt tattatcaaa tgaatggaaa
    51421 ttagatgatt tagatgatat ggtaaatgta gtatcattgg aagagttaaa tgatagtata
    51481 gattcaataa tggcaggaaa acatgttgga agaacagtag ttgatttaga aaaaatatag
    51541 gtgaataaat ttataattag gattataggt tttaagcaaa aatgagatac ttgaaattta
    51601 cttatgagta tctcattttt ttatgtaaaa agatttatgt agatgtttgt gtaaaaagat
    51661 tattcatgaa caattaattc aaatacatct ggtcttgaat agtgaccttc tgaatcaaaa
    51721 tctagtctac taagtactat tttttctagg tctaaatcag ctattagcat ttcttcttta
    51781 ttgaaaatag gacctgctac atattttcca aaagggtcaa ctatacaact tcctcctgga
    51841 cacataattt ctggttctgc atctagctcc ttatagtagt taaggtcagt tgggtacgta
    51901 tttttttcaa catattgatt gcatccaatt acaaaacatc ttccttctaa agcaatatgt
    51961 ttcatagttg cttgccactc ttctcttgaa tctgcagtag gggctatgta aagttttaca
    52021 cccttagcat aaagagctgt tctagctaat ggcatataat tttcccaaca aatcaacgaa
    52081 cccatttttc catatggagt atcaactact gtaagagtac ttccatctcc ttctccccaa
    52141 atacatcttt ctgttcctgt aggtttaagt tttctgtgtt taccaattag cttaccttct
    52201 ggagagaaaa ataagtttgt gcaataaagg gtacaattta tatcattacc atctctttct
    52261 gttataccca ttgatagata tactcctgct tcttgtgctg cttttcctaa taaatctgtt
    52321 gtagcactag gaactggtac agaattatca tagtatcttt tccaatcttc tctaccttcc
    52381 attgttctac ttccaacaac aaatccaaat gaaagacctc ttggatatgc aggtatgaat
    52441 gcttcaggga aaactacgat atttgcccct tttctaccag cttctttaat taatcctaat
    52501 gctttttcaa cagttttttc taaatccatt atgactggtg acgcctggac aacagcaatt
    52561 cttacatttt tattttcctt gctcataaaa aacctcctaa aaaatattta aattttttgc
    52621 attgaataga ttacatgaga tgttatttga gaactaagat acttatattg tgaataataa
    52681 tgtaactgta tatttaaaat aatacatcat gatttaaaaa attacaattg tacagatata
    52741 attgagttta gatatttaaa tttaacaact tataatattt tttcaattag tataaagcct
    52801 attaatttgt cttatttaca atgaatagta tttacttctt ggcaaacaat aattaaaaat
    52861 aaaactttta tatgattaaa ctctaaagaa aaagtttata aagaagataa tataattaag
    52921 cagaaaataa tgaaaaaaat ttattaaagt agacaacgta aggagaattt tatgaaagca
    52981 aaaatttatt acaatggaaa tatcatcaca atggaagatt caatatgtgg agatgctatt
    53041 cttataaaag acaaaataat aaaaaagata ggaacaaaag aagaagtatt tgctttgaaa
    53101 aataaagata cagaaattat agatttacaa ggtaagacat tgatgccatc ttttatagat
    53161 tcacatagtc acttgatagc ttttgctact actctaaagc tagttccttt agaagatgca
    53221 accagtttta aagacatagt aaaaaaaata caggatttca aagagtcgaa taatataaaa
    53281 aaaggagact ggataattgg attttcatat gataataatt ttttagaaga aaataagcat
    53341 ccagataaga gtgtactcga tagtgcatct tcagaaaatc caatactaat ttcacatgct
    53401 tctggtcata tgggagttgc aaatacattg gggttaaaac agcttggtgt taccaatgaa
    53461 acacgtgacc cagaaggtgg acatataggt agagtagaag gcagtgaaga accaaatgga
    53521 tatttagaag aaaatgcatt ttttaatgta gcatctaaaa taaaacaacc atcatcaaat
    53581 gagattttta attcaattga aaaagcacag aacatatatc taagctatgg tattacaaca
    53641 gctcaagaag gtttaatgga agaaaatcaa tttaacattt taaaagcaat ggcaaatcaa
    53701 aataaattaa aaatggatgt tgtaggatat gtaaatttga aaaaaagtaa gtctgtagca
    53761 gataataata gggagtttat aaaaaaatat ataaatagat ttaaaatagg aggttataag
    53821 attttcttag atggttctcc acaaggtaag acagcatggt tgagtagacc atatgaaaat
    53881 tcagatgatg gttattgtgg atatcctata tacaaagatg aagaagtaga aaagtttata
    53941 gatatttcac taaaagaaaa gatgcaactc ttaactcatt gtaatggaga tgcagcagca
    54001 gaccagttga tagatgcgtt tgagaaagtt ttaaacttaa aagagcaaag tagtgaaaat
    54061 aatataagac cagttatgat acatgctcaa acagtaagag cagaccagat tgatgatatg
    54121 aaagtaataa atatgatacc ttcatatttt gtagctcaca catattattg gggtgatatt
    54181 catatcaaaa accttggaga agatagagcg tttaagatta gcccacttaa aacaactata
    54241 gaaaagggat taatttacac tcttcatcag gatacaccag taatagcacc taatatgctg
    54301 gaaacagtat ggtgtgctgt caatagaatt acaaaaaaag gtatacaaat aggagaaaat
    54361 gaaaagataa gcccattaga tgctttaaag ggtgttacta taaatgcagc atatcaatat
    54421 tttgaagaag ataaaaaagg ttcaattaaa gaagggaaat tagctaattt gataatatta
    54481 gatgaaaacc cacttacaat cgaccctatg aaaataaaag atattaaagt attgcagact
    54541 ataagagaag gagaagtatt gtattctttg aagtagatga aagttagata ttttataatc
    54601 tataaaaaat agttttatat aataagttag gtagaattaa ataagattac agttaaatca
    54661 acaattatat ttttattaaa ttttaattat tgtattgaag atttataagt ataattttat
    54721 tgattctacc tttttaaata actgtagatt tattaaagtt atctatgtac tatattaaac
    54781 aattaagtag ttattaattg cacttattag tttattaaaa aactatgtat attactttgc
    54841 agtaagactt tggaactaaa tctataatag caaatttaaa tttattaaat agattaactt
    54901 ataacatttc atataaaata tattgtgaat ctgagaaaat tactattttt ctttgagtat
    54961 tttttgtaag cagttctaaa agattcaatt tcatacctat tacttgaatc attcatcaaa
    55021 ataattctaa tttaaaaaat aattctatcc aaataataga tatataggac tatgttataa
    55081 tataaaaaaa tttatataaa agttaataac tatacaagat tgataaagaa aaagtcaaaa
    55141 tagataattg attagcaaaa tagatataat tataatgaag ttaaatctag caatattctc
    55201 ctaaaattaa atttcattta tttaattaaa tataatttga caatgggcaa aaaagtgagt
    55261 aaaatataaa taaaataaaa ataacaggtt cggataaaga aaaaggtttc ttaacctcaa
    55321 gcataaagta tattatctaa gttatttgag attaagagat aaatccaatc ttaggtactg
    55381 aggaggaaaa aatgcttgat ataaaaagaa taagagaaaa tttagattgt ataaaaaaag
    55441 caatggaaag aaggggcgaa aaaaacttta accttgatga agtagttaag ttagatgatg
    55501 aaagaagaaa gactcttcaa gaagttgaag ttatgaaaaa tgaattaaat acagcatcta
    55561 aaaatatacc aaatcttata aaagaaggta aagatgtaga aaatgaaaag attaaattaa
    55621 aagagttatc tgataaaatt aaggtaatag accaaaatct taaagaagta gaagataaga
    55681 tggaatacct attaatgaga ataccaaatg taccacatcc agaagtacca caaggtgaaa
    55741 ctgatgaaga taatgttgaa gtaagaactt ggggaaagac tactaccttt gattttgaat
    55801 ctaaggctca ttgggaaatt ggaacagaat taggtatact tgattttgaa acagctagta
    55861 aaataactgg ttcaagattt actctttaca aaggattagg tgctagatta gagagagcat
    55921 tattaaattt ttacttagac acgaatacaa aagtaaatgg atatacagaa gttattccac
    55981 catttatggc aaatagaaat agttttttag gtacaggaca gttacctaag tttgaagaag
    56041 atatgtttaa aatagaaggt atggactatt ttatgattcc aacatcagaa gttcctttaa
    56101 ctaatataca tgctaatgaa atacttaaat ttgaacaatt accgataaat tatacagctt
    56161 atactccatg ttttaggtca gaagctggtt ctgctggaag agatacaaga ggtttagtaa
    56221 gacagcatca gtttaacaaa gtagaaatgg ttaaaatagt tgcaccagaa gaatcttaca
    56281 atgagttaga aaagcttact aacaatgcgg aaactatgct acaattattg aatctgcctt
    56341 atagagtagt aaagatatgt acaggtgatt taggatttac ggcttctttt aaatatgatg
    56401 tagaagtttg gatgccaagt tacaataggt atgttgagat ttcatcttgt tcaaactgcg
    56461 aagatttcca agctagaaga gcaggaataa gatttaaaag agataaagat tctaaagctg
    56521 aatatgtaca cacattaaat ggctctgggt tagctattgg aagaagtgtt gcagctatat
    56581 tagaaaatta tcaacaagaa gatggttctg tggttgttcc tgaagtttta agaccatata
    56641 tgggagtttc tgttattaaa taagagttaa attatgtatt tttaagtaat acaataatat
    56701 agaggtaata aaaaataatt aatataaaag tgatacaata atatagaagt aataaaaaaa
    56761 tagttaatat aaaagtgata caataatata gaagtaataa aaaatagtta atgtaaaagt
    56821 gatacaataa tatagaagta ataaaaaaat agttaatata aaagcgatac aataataata
    56881 gaagtaataa aaaaaaataa ttaatataaa aatgtgtaca aactaatgaa tattgatata
    56941 gtaagctatc atatgaaaga gtatgtacac atttttttta ctaatttttc acaatatgaa
    57001 cataaataat ttacaggaaa ggaatctttt atgaaaattc aaaatactga gtggggatat
    57061 attgaatgga aacatactta tgatgaaaat aatccaaaac aagctatgaa tatatacatt
    57121 gcagtaacta tgcctggtaa gaaacatttt aatcatgttc attatggtca agagcagatg
    57181 atatatattt tagagggaga gggtttgtat attataaatg gagtttggaa gccattttat
    57241 caaggtatga ttttttatat agaatctggt agcacacatg aaactataaa tacaggcgat
    57301 agagaaataa aagaacttat tgtttcaaat aatgtagatg atgtaggaga gagtgaagtt
    57361 atagatatta atcctaataa ttatttaaag aagaccttga taaattatag tgaaagtaca
    57421 ttaaatttgt atgcagcagt agaatcaatt cgtggtcaat ttatagaccc gtttaaaatt
    57481 ccattaatta tatatgatga ttcatggaat atagttttaa aaaatcctta ttttccactt
    57541 ttttgttttg aaaaatgtaa tcctatgaaa tttcctcaaa attgtgattg tatgaatcaa
    57601 aaaagtagca atcaatttgt atgtgaatat gggataacta tatataatat accaatactg
    57661 tacaaaagca atagcatagg tgttataaga ggagggtatg tactattatc tgatttgaat
    57721 ttagatacag agcataataa tttatatgat attccagagg gagctgctag aagtataaaa
    57781 cgcctcttga aacaaatatc taaaaatata ataaattttt gctcttttaa tgatataaga
    57841 aaggatttac aagaaaaaga gaagactata gcaagaacat atcattatgg agagcaactt
    57901 gaaatgaatt taaaagtagc tcaagatatg gttactaatt taagaataaa tcatcacttt
    57961 ttatttaata cattaaattc aatggcaagc atagcactag atgatggtag ttatgatttg
    58021 tatagtgcaa taatagattt atcaagaatg tttagatata caatgaggtc tgatttaaga
    58081 tttgtagaat tagaatctga aatattatac attaaaaatt atttgaattt acagaaatta
    58141 cgttatggag atgcacttaa agtaaaatat cttattccag agaagttata taacctttct
    58201 gtgcctttta actttattca acctattgta gagaatgcat ttacacatgg atttagagat
    58261 attgacacag aaaagcgaat tgaaataatt gcaagattag attctcagta tgccattata
    58321 gagattcata ataatggaac tatcttagat ggaaataata tagacaaaat aaaggcaggt
    58381 attcgtagta ataatggtca tggtttgtct ttaatatata caaaattcac atctgcttat
    58441 ggaaataatt ttgatatgga tataaagtcg agtgataatg aaggaactta cataatgatt
    58501 aaaattccta ttgaaaatta taaggagtat gtatagaact tgtgaaaaat taataagttt
    58561 tataaatgtt aagaaatata ttagatgttt ttatgttgtt ttatatatct tactttttta
    58621 tattattaag ctaaaaggga ggtattctca tgagaagagc actaataata gatgatgaag
    58681 aagctgttct aaaaataata acacatttta tagaaatgaa agatatgcca ataaaaattg
    58741 ttggtaaagc aacatctggt gatgaagcag tagataaaat cattggttta gagccagaca
    58801 tagtttttat agatattcaa atgccaatat acaacgggtt agaagtaata gaaaaaacat
    58861 ctcatttatc taaaaaaata aactttgtag taataactgc atttaactat tttgaatatg
    58921 ctcaaaaagc tttgagatta aatgtaaaag atatactcct taaaccattg gatatgaaag
    58981 aatttactaa gtctgtagaa aaaattattg gatatcaata taccaataat gatttattaa
    59041 atgagatact ggaatatata aatctaaact atagcaatga cttaaagtta aatgattgtg
    59101 ctagattatt tttaaccaat ccatctaata tatctaggat ttttaaaagt aatttaaata
    59161 caacttttat atcatatcta aatcatataa gaatagaaaa atctattgag ttacttgaaa
    59221 atactacaaa aagtataaat gagattgcag aaatagttgg atataatagc ctaaataact
    59281 tttataaaaa ctttaagata gaaaaaggaa tgactccaaa agtttataaa ctgaacacta
    59341 aaaattgaaa ttgataaata aaaagtcaat atagataatt gtttgagtgt gtctgaataa
    59401 gtatacttta attatgataa aaattaaagc gctttaaaca tatttaataa tattaaacct
    59461 tataaaagct gtacctattt atataaaaaa atatatataa ataaaaagaa aaagatatac
    59521 aaaataaaaa aagtgaatta aatactgttt caaaaagaca gaattttcat ttaatttact
    59581 gagagtttat atttcttaaa ggaaggtaac tttataatgg aggtaattta atatgtcaga
    59641 caaagtgaat atgaaaaata ttatctgtat tgcaggcgct tatctagcaa cagcaattgg
    59701 ttctgggttt gctactggtc aagaaattct acaatttttt gcctcacaag ggtatatggg
    59761 tttaattgga gcattaatat caatggtatt gttttcattt cttggtgctg aagttataac
    59821 tagaggtaga gaattaaaac ttaaagaacc aacaagaatt tacacttttt attgtgggaa
    59881 gattttagga aaattttacg aatggtttag tccaatattt ttatttggga ttcttatagt
    59941 aatgatttca ggtgcaggct caactttaac tgaatactat ggtataaatc cttacttagg
    60001 aagagtattg atggctgttg ctactttaat tacagtgtct atgggtttag aaaaattagt
    60061 aagcatactt ggacgtattg gaccagtgat agcagtattt acaattgctg ttggattaat
    60121 aagcttgttt aagcattttg acggtttatc tatggttgga gaagctatga aaaatattga
    60181 agttacaaaa gcatcagaaa gtccaatcgt ttctggtgta atatataata cattaaatat
    60241 tattgtaatg attgtttttt taacaggaat gggagcttct attgaaagta aaaaggatgc
    60301 tttttgggga ggtttattag gtggaatagt gtttatgact gctggtatag ttatgtattt
    60361 ggctatgatt tcagatatag gaaatttgta tatgaaagaa ataccatcac tttatttagc
    60421 agataatata tctccgattg taggtgtatg tttttcagtt gcattaatat taggtatcta
    60481 tacaacagct gttccacttt tatggtctgt aaccaataga attgttgaag atgaacatcc
    60541 taaatttaaa ttggtaacaa cagtaatagc tattttggct tgtataggag gttttttacc
    60601 gtttggtaaa ttagtaaaca ttttatatcc atatacaggt tatatggggc ttttaatttt
    60661 agtctgtatg gtgtataaag caattacatg tagaaaaaaa tcaacacaaa gtcaggaata
    60721 gagccactta ttaatagttt ttatttaaaa aaatttttta tataatccga atttaaaaag
    60781 tcaaaatagt taaataaatt gcaaaacatg ataatatatt taattaaaat aatatagtaa
    60841 aatataaata taaactaaaa ttaaatttat aaaaaatatc tttataaaga ttattaactt
    60901 atataatttg tagttaaatt ataaaaaata aaaaaataaa attttggaga ggtgttagta
    60961 tgcatgaact tattttaatc tcagaaaagt ataaagaaga tattttagat ttttttacag
    61021 atattcatat gcaccccgaa ttaagtttta aagaatttag gactacaaaa gctataaaag
    61081 atttattagt gagtttagac atagaaatat tagatttagg aatggaaaca ggcgttgttg
    61141 gattattaaa agggaagtat gatggtccca cagtagcact aagaggagat attgatgcgt
    61201 tgccaatata tgaagaggtt gatattaagt ataaatccag atatgatggt ataatgcatg
    61261 catgtgggca tgatatacac acgtcttgcc ttgtaggatg tgcatatgta ttgtctcata
    61321 ttagagatag tcttcatgga aatgtaaagt ttatatttca accagccgaa gaagtcaata
    61381 aaggtgcgaa gatgttagtg gaacgaggag taatggaaaa tccaaaagtt gatgctatat
    61441 ttggacttca taatcatcca gatatacctt gtggaaaaat aggtgttaag ttaggtgggt
    61501 taatggcagc agtagacact attaagatag aagtaaatgg atttggaggt cacggaggta
    61561 taccaaacag aacaatagac cctatagtag catcaagtgc aattataatg ggtattcaaa
    61621 ccatagtaag cagaaacata agtccattag aatcagctgt tatatcaata ggtactataa
    61681 atggagggac tgcaaataat gtaatttcag aaaaggtaga tatgacaggc acatgtagaa
    61741 gctttagtaa tgaagtacga aagaaaatat cagaaaattt agaaaatata gtttgtgaga
    61801 tagctcgtgg atatcaagca actgcaaagc tagattattt atttgattta ccagctgtta
    61861 taaatagtaa agagatgtac gcaatagctt gtaagtctgt gtgtgatttg tattcagaag
    61921 atgctatagt tgatccaata ccttctacag gaggggaaga tttttctata ttcatggaaa
    61981 aagccccagg atttttttac tggttagggg taggcaacaa agaacaagat tgtatatatc
    62041 agtggcataa tcctaaattt aaagctgata aaaattctat attggtaggt acaaatgtac
    62101 tatgtcagtc tgttataaat tatatggata aattaaaaaa taaaatttaa gatagagcat
    62161 tctggagata aagtttatga gggggtatta gtttgaggaa aattaattca caggaaaaaa
    62221 acaaagatag tggattattg atgagggcac taaatgttgt agagagagca ggaaataaac
    62281 ttccagaccc agtaaccata tttttattac tatgtataat tgttgtaata ttgtcagcag
    62341 ttatatctaa tttaggagta gaagaaatac atccttctac aaaagaagtt gtaaaggtag
    62401 taaatctact agagaaagag cagattcaat catatttagg tagcatagtt acaaactttc
    62461 agtcatttgc tcctttagga ttagtactgg ttacaatgct tggagcaggt gttgctgaga
    62521 aatctggatt tatggaagtg ttaatgaaaa agggtataag taaagttcca caaaaacttg
    62581 taactgtagc aatcgtattt gcaggtatgt tgtcacatac agcagcagat gtaggattta
    62641 taatattacc accacttgca gcacttgtgt ttttaggaat tggaagacat cctcttgtag
    62701 gtatgtttgc agcttttgca ggtgttgcag ggggatttgc agcaaatgtt atgcttagta
    62761 ctacagatgt attgttagct ggatttacaa taccagcagc tcaaatgatg gacccatctt
    62821 accaaggcaa tccagcaatg aatctttatt ttgcttttat atcagcgata gttttaactt
    62881 ttgcaggagc atttgtaact gaaaaattta tagctcctcg ttttacaaaa tataatgatt
    62941 caacaaatga taaggatata caggaattga gtgaacttga aaataagggt ataaaatacg
    63001 ctttattatc attgttagtt gtagtagtag tgatagttgc cttatgtata ggtgacaatg
    63061 catttatgaa agatccagag actggttcta tactatctag taatgcacct ttaatgaaag
    63121 gtatagttcc tataatcact attatatttt taactccagg attagtgtat ggaaaagtaa
    63181 gtaagaagat aaaaagtgac aaagatttag tatctatgat gggtagtagt atgagtgata
    63241 tgggtggata tatagtccta gcatttatag catcccagtt tattaattta tttaatctta
    63301 gtaacttagg aacaatttta tcaataacag gagcaaaatt actagcagag tcgggaatac
    63361 ctagctatgg attgataata ggatttatat tgctatctgg atttatcaat ttatttgtag
    63421 gaagtgcttc tgcaaaatgg gcgattttag cacctatatt tgttcccatg tttatgctac
    63481 tagactttaa tccagcatta actcaaatag cttatcgtat tggagatgct tcaacaaatc
    63541 caataagtcc actttttccg tattttccag ttatattggc ctttgccaga agatatgata
    63601 aagatatagg tataggtact gtcatatcga atatgattcc atactcagtg gtatttacat
    63661 taatagaaat aataatattg ttactattca tgggtattgg cataccatta ggacctggtg
    63721 gaggaatatc ttacgtttta tagaccgtta taataaattt atcaatgaag attaaactaa
    63781 taaaatatat tctttaatta agaggaggat tattatgtta aaaacaacaa aaatttcaga
    63841 cccagagtta tacaagattg tagctgatga gttggttaga caagaacaca atattgagat
    63901 gatagcttct gaaagtacag caccaacaga agtacttgaa ttaagtggat gtgtatttac
    63961 aaataaaaca gaagaaggct atccaggggc tcgttttcaa gcaggttctg aagaagcaga
    64021 taaacttgaa accctagcaa taaaacgtgc aaaagaagta tttggagcag aacatgtaaa
    64081 cgtacaaccg tattcaggtt ctacagctaa ctattgtgta tattcatcaa tattaaaacc
    64141 aaatgacact gttttaagta tgcgtcttga ccaaggtgga cacttgacac atggtagcgc
    64201 agttaatttt ttacatgaca tttataaata tgaattttat ggggtagacc caaatactgg
    64261 acgtatagat tatgatgctc ttgaagcaaa ggcaaaagaa tgtagaccaa aacttataat
    64321 tgcaggggca agttcatatc caagattaat agattatgaa agaatatcaa aggttgcaaa
    64381 agaagtagga gcttacttta tggtagatat ggcacatgtt gcaggattag tcgcagcgaa
    64441 agtaatacct agtcctgtac cttatgcaga ttttgtttct tcatctacga caaagacttt
    64501 ctgtggacca agaagtggta ttgtactttg taaagcagaa catgcaaaga aactcgataa
    64561 aggtgttttt ccaggaacat tagggtctat acatcttaat acagttgcag caaaagcctt
    64621 ttcactatta tatttaagta cagataaatt taaaaagata atggagcaag ttgtagtaaa
    64681 tgctcagact ctagcttctg aactgatttc acatggtttt agtattgtaa gtggaggtac
    64741 tgataatcat atagtaatgg ttgacttaag aagtaagaat cttacaggaa aacaatttga
    64801 aaaagctctt gaatatgtag gaataacagt taataaaaat gttatacctg acgacccaca
    64861 atcaccattt gtaactagtg gtgttcgtat aggtcttaca tcaatatctc aaagaggtct
    64921 gaaagaaaaa gaagttatac agatagcagg gataatgaat aaggtagcag aaaatattga
    64981 taataaagaa gtattagatg aatgtaaagc agaggcacaa gaacttatat ctaagtttcc
    65041 attatatcca gaagggtatt ttgaagatta aatattttga tttgtatagc tcacaattta
    65101 taaagcctgt aacataaaat ttaataatat ataaccacta taaggtgttg attaatcaac
    65161 accttatttt ttttgaaaag taatatacaa gctatcataa gcatataatt ccttatagat
    65221 aattaacaag ggggataaag ttatgaggta ttataataaa cctaccaaag aagtattaaa
    65281 atacttaaaa acaaatccag aaattggact tgatgataat gaggtagaag aaaggaagct
    65341 tagatatgga ttaaatgaat ttactataaa agaaggtaga acattttggg acgagttggg
    65401 agaaagtttg acagaaccta tgatattaat tctcatagga gcagcagtaa taagttcttt
    65461 tgtgggagaa ttacatgacg cattaggtat tttaggggct atttttattg gaatttctat
    65521 aggcataata actgaaggaa aatctaaaaa agcagctcat gccctgtcaa aattaacaga
    65581 aaatatagaa gtaaaggtgc ttagaaatgg gaagataatt aaaatatcaa aaaatgattt
    65641 agtaccagga gatattgtat atatagaaac tggggatatg ataccagcag atggaagact
    65701 tatacagtct ataaatttga aacttagaga agatatgcta acaggagaat ctgatgatgt
    65761 agctaagaat gctgatgctg tattagatat ggaagtagtt tattctaaaa cagaaataat
    65821 cgaacaggat gcaatacctg caaagcaagt caatatggta tttggaggga ctcttgtagc
    65881 atatggtagg ggcataatgg ttgtcactca tactggtgat aagacagaga tgggtaagat
    65941 agcacagaat ttatcaaatg aagaccagca aactccactt caaattaaat tagggaagtt
    66001 gggtgctaaa atagcgggaa tatcaggcgt aatagctact ttattatgta tgtttatgat
    66061 tatacagatg cagagaaaag gtatgttaat tttagataca agcagtgtat tatctttctt
    66121 acaatcatta gaacctgcta aaaatgcata tatggtttgt attgcattaa tagttgcaac
    66181 tgttccagaa ggtttgccaa ctatgataaa tattacctta gctataacaa tgcaaaagat
    66241 ggcaaagata aatgcattag taacaaagaa agaagcctgt gaaactatag gttctgtttc
    66301 tgtaatatgt tccgacaaaa cagggacttt aacacaaaac aaaatgatgg tagaggtagc
    66361 atatgttgat ggtaaatata taagtggagg agagtatcaa agtaatagct attttgaaca
    66421 aaactgtata gtaaattcaa ctgcagatat agaaaaagaa gataattcat ttaaatatat
    66481 aggaagcgca acagagtgtg cattactttt atatcataat gataagaact ataatgaaat
    66541 gagaaaacaa acgtatttga tatcacaaat accatttagc tcagaagaaa agaagatgtc
    66601 aacattaatt cgtcaagagg attcagatat attactttca aaaggtgctc cagaagtatt
    66661 attaaaaaaa tgttcttatg tacaacaagg aaaaaatatt gttccaataa ctccaaaagt
    66721 agaaaaaagt attttagatg agattaagaa gttacaaatt aaatctatga gaacattagg
    66781 atttgcttat aaaaaaatga gtaattctaa aacagaagtt gcaatgactt cagaaggtga
    66841 attgaattta ataggaaatt caagaagtta tatgaaggaa gataatttag tttttagtgg
    66901 atttgtagga atagtggacc cattgagaga aggggtcaaa gattccattg ataaagcatt
    66961 taatgcagga gtagatgtaa aaatgcttac aggagataat ataaatacag caacagctat
    67021 tggaaatgaa ttaggattat taaatgatgg gaaaaaggca gttgaagcaa catatataga
    67081 tgtattgaca gataaagaat tgagagaaga aatcaaagga atatctattg ttgcaagaag
    67141 taaaccagat acaaaaatga gaatagtttc agcacttcaa aaaagtggcg aagttgtagc
    67201 tgtaacaggt gatggtataa atgatgcccc agcacttagt caagcagatg ttggaattgc
    67261 aatgggtatt tcaggaacag aagtatctaa aaatgcagca gatataatat tgactgatga
    67321 tagctttagt actatagtag agggaataaa atggggaaga ggtatatatg agaactttca
    67381 aagatttata cagtttcagc ttactgtaaa tatagtagca tttataattg ctataatatc
    67441 tcaacttact ggtaaggata tgccatttac tacaatacaa ttattatggg taaatataat
    67501 aatggatggt cctccagccc tagcattagg attagaacct gttagagatt atgtattgaa
    67561 aagaaaacca ataaatagac attctggaat aatagctagg tctatgtttg taaatattat
    67621 tataaatgct attcttataa ttacaattgt atttactcaa tcagctttta atatattggg
    67681 agctacatca gaagaacaag gtactgttat attttcttta tttgcattca gtgccctttt
    67741 taatgcatta aattgtagag agtttggttt aaatagtaca ataccaaatt tctttaaaaa
    67801 taaactggca ttgcaaataa tagtagttac agggataatt caaataatat ttacacaagt
    67861 gttccagagt ttctttaatt ctgtttcttt ggactttgat atgtggataa agataatact
    67921 atttgcatcc actatcctat tgtcaaatga atttgtaaag ctaattctta gaacaatgaa
    67981 aaatagtaga actatgaact ttaatagtaa aaattaattc ctatgaaacc gcaaagtact
    68041 atatattgta actttgcggt ttttgtttgt ttaatgttgt tttatattac cattttcata
    68101 tttaattttt tattaatcta aacacaatct tccattgtaa ttgcttcatc tgtgtcaaca
    68161 cattcaaagt caatatctaa tttttgtaat attttgtatg cctctttttg caaaggagta
    68221 tcaaattcaa taggtgattt tgtgtaaata taactgataa aaaacatgat ttatttcatt
    68281 cctttccatt taaaaactta tagttatagt gtatcataag gttataaaat atagataaat
    68341 atagtataaa tttaaaatat gtacagacaa aacaaaaaaa tcatattcta agtaatactt
    68401 gggaaaaatg atattatcat aataaataat ctttgtaaaa acttatatag aatctattaa
    68461 acagacacta agccataaaa actttactaa atataaaatt cgtatctaaa tagatatata
    68521 gaataatatt ttactgaagt agagtgattt ttaagaattt tatatataaa ttatgttatc
    68581 ataaataaag atatagatta taaaatttgt taataaaata aagggcaggg aggtaagttt
    68641 catgttttcc aaaatcctag tcaaaacatt tatcagagat agcgaaaacg ttcaaaatac
    68701 agatgttaga aataagtatg gttatgtagc tggtgtagta ggtatattat ccaatttact
    68761 tttatttgtg ataaaggtat tcataggaat gctcacatct agtatagcta taatggctga
    68821 tgcatttaat aatctttctg atatggcatc ttcagcaata actatgatag gttttaaatt
    68881 agcaagtaag ccagctgata aagaacaccc ttttggtcat ggaagaatag agtatttatc
    68941 agcattaata gtagcattta tggtgatgtt ggttggactt caatttgtaa agtcatctat
    69001 agaaaggata gtaaatccaa ttcctgtaaa atttgaagta ataccactta tacttttaat
    69061 tgcatctata atgattaaaa tctggttgag tcgttttaat aaatttatgg gaaataaaat
    69121 tgattcttca gccttaaaag cagtttcact tgatgcttta ggagatgtat ttacttcaag
    69181 ctgtgtagtt atatcattta ttgtagctag atttactaat tttcctatag atggatatgt
    69241 tggtatcgta gtatcattag tgatacttta tgctggtttc tctcttgtaa aagatactat
    69301 aaatcctctt ttaggggaag caccagatga agaaatggta aattctatta tagagctatt
    69361 gttatcttat aaatatataa taggtacaca tgatttaatt attcataact atggagttgg
    69421 tagatgtatt gcatctatac atgcagaaat tccatccaac atagatataa tggaaataca
    69481 tgaaattata gatactgcag agagagaaat atctgaaaaa ttagatatat atctagtaat
    69541 tcacatggac ccaatatgtc ttgaagataa agaagttatg tcagccaaaa aagaacttga
    69601 agaaatactt aagaaaaata gtcttgtaaa atctatgcat gattttagaa tagttggaaa
    69661 aggaagcaag aagaatttaa tatttgatat agtagttaat ccttccgaat tttccaaaaa
    69721 catgtcagaa gatgacttaa aagaagatat aacaaaatta gttaaggaga taaatcctga
    69781 atataattgt gtaattgttg tagataagga ttttatttaa ttattaatta atctcatcat
    69841 aaggtaaaaa atgtaaaaag gatagacaat agtatagagg cataatataa tagaagtata
    69901 taattgtatt tttaatataa ataaagcaat tttaattgtt tttatgaaat attatagaga
    69961 tgttgaagta tattctatta ttgggcacct tatggatata ctgagtcagt ggtgcaaccg
    70021 gctatgaata taaatttatt tattttcata gctttttttg tataattttt tagtaaaaat
    70081 tactttatat acgatattaa tggaagatta gattataaat tataggtaac ctaaaggggt
    70141 gagatttaca tgaagaaagg aaatagaaag gcattattaa ttagtttaat tatgatttta
    70201 agtatggtgg tgtctacaat atatccaact gtatcttatg cttcagaatt aggagagaat
    70261 agtcagattc aaagtggttc aactaattca tcaactggag aggagaagga aagcgacaat
    70321 aaaaagccag aacagactcc agagaaagat aaggcaacag ataataaaaa accagaacag
    70381 accccagagg aagaaaaacc aacagataat aaaaaaccag aacagacccc agaagaagat
    70441 aagtcaacag ataataaaaa gccagagcaa actccagaag gagaaaagcc aatagataat
    70501 aaaaagccag agcagatacc agaagaagat aagtcaacag ataataaaaa gtcagaacaa
    70561 gctttagaag atgaaaaacc actagacaat aaaaatacag aaaaaactcc agaggaagat
    70621 aatctattag aagatgaaaa tttattgaaa gttttagaag aagaacttaa tgaagaaaat
    70681 gaagactatg gatttgttgt aaaaattaat aacaatacaa tagaaacgga atcaatgaaa
    70741 aaaatatcat ttaatttaac ttatactcca acatcaaaag gaatacaagc aggagattca
    70801 ataactttta aggtgccaga tgtattcaat aaagttaatt tagattatac aagtgaatgc
    70861 tttgataaaa cagaaagtaa tggagagtat acacttacat ttagagaatt acctaatggc
    70921 caaagtgtaa tgcaaggtaa aataggtttg gaagcatatg ttaaaaaggt tgatgaagat
    70981 actaatgcaa aaatacatat tgaaactact ggaaaaatag aaagtggaag tggagatata
    71041 gatgtagaaa taaaacctgg agataaaacg gatgttccag atgctaaagg aacacttaaa
    71101 aagcttgttg aaggaaaaaa atcaactact gtatttatgc cagttaaaaa taaagatata
    71161 aattacagta tacaagtaaa tgaaaagcag gaagagttaa aagatattat tttgtatgat
    71221 gagcttcctg aaggattgac attgataaat ggttctgtaa gtgtagtaac aagtgatgga
    71281 aaagaagtta gtgattttaa tattgaacag agtaaaaatt ctatttcagt taattttgga
    71341 aatatagata aatcgtatac tgttaagtat aaggctagaa tcagtgacaa aaacgcaaaa
    71401 catggtaata aatataagaa tgtagctagg attgaatctg atggtaagaa gatacaagaa
    71461 gatgatgcta ctgtaagtat atttgataga ggagatgatt atcttcttac taaaggacat
    71521 tcaggagcaa caaatattac tcaagttggt caagtaataa actatcagat ttcaataaat
    71581 gatgataaat caccaataag taatgttgtt ataacagata atataccaga aggcatgaga
    71641 ttaactactt caggagaagc tgggcatgat tttagagttg tagaaattcc aatgaatggg
    71701 agctggactc cttggagtaa agaaaaaatt gccaataata tttcatataa agtagaagaa
    71761 aaaagaaatg aaagtgggca agtagataaa gttataactg gatttacaat taatctcagt
    71821 aaagaagaag tggaatcaaa gttttttata gcttatacat taaaggtaat tagtattgaa
    71881 gatagctata taaatagagc tgttcttgat gcaaataata gtgaaattga taaaaatgat
    71941 gagataaact ttaagaaaaa ttctggatta ataagcgcaa aaaaagaagt tgataaaaaa
    72001 gttttaaata gtagtgataa ccagattgtt aaatacaaaa tcaatatgtc aacttatgga
    72061 gtttatgatg caggacaagt aaatctttta gatgaagtaa actcagctct agaaatatct
    72121 aatataaaat attctgataa tcttgaactt aaaaaagaag ctggagatgg aaaaaataca
    72181 ataagattag taaataaata cgaatttaaa cagataaaag aaggggaacc tgtgcaaagt
    72241 tgggttacat ttgatgcaga cttcacaaat gtaaaagttg gggagactat acaaaatgtg
    72301 gctcagatta atggttcaag tcctccagga gtagagacta ctaagcaagg ttatgctttt
    72361 gaagctaaaa aagtggatgc tttagataaa aatgtacttt caggtgctaa gttcaattta
    72421 gaagatgcat ttggaaatat agtagttaag gatttagtta gtgatgaaga tggtataatt
    72481 caatctagta taaaaaaacc aggaacatat tatttagtgg agataatggc tccaagtgga
    72541 tatgaaaaac tgaaggataa aattaaggtt gaaattggta ataaagatat tggtagaata
    72601 gtggatattg gaaatataga aaacataaga caagaaaatc caccagtaaa tccaccagca
    72661 ccaccaaata cagatgaacc aatagtaaat ccaccagtac caccaagcac agataaacca
    72721 aggaaaccat caagttcatc tgatacagag gatactatag ttataaatcc accaatacca
    72781 ccatcagaag atataataaa tccgccaata ccagaggtat tgaatccgcc agtaccacca
    72841 tcagaagaga tgatagaaac tcctgttaaa cagattattc caataccaga agtagtaaag
    72901 ccatcagtgt cagaagaaaa aaataataaa gttaaagatg atactttggt aaatccacca
    72961 gtaccaccaa aaacagggga tagtactaca attattggag aaatactttt ggttatagga
    73021 gctattgtag gacttatcgt attaagaaga aataaaaata caaattagac cctaacatta
    73081 taaaaaatat aagttatatt aaaaaatatc ttctaaaaca atatttaata atgaaaatat
    73141 tgttagaaga tatttttttt tgaagattta tgtaaaaaaa taataacttt ttagaaaaaa
    73201 gttccaaagg gatatagaca attaaaaaga tataagctat aatatagata taaaattaaa
    73261 tgaggcaaaa ctagggaaac ctagtcacgc aaagctatag gggctaaagt ttagtaaacc
    73321 atgccagcca gttgccgaaa agagtaaaaa tttctttttg tatatacaaa gatactcttg
    73381 ggtatctttt ttattttgaa atttattact cccggcctaa ctcaaaggag ggaataatat
    73441 gagaccaagt aaaaaattat taatagctat aatatcaata ttcttaataa gttcagttcc
    73501 agtaagtgca catgcagata gtactactat acaacaaaat aaagacacac ttagtcaaat
    73561 agtagttttt ccaactggaa attacgataa aaacgaagct aatgctatgg taaatagatt
    73621 agctaatata gatggaaagt atttaaatgc attaaagcaa aataacttaa aaataaaatt
    73681 attaagtgga aagttaacag atgaaaaaga atatgcttat ttaaaaggtg tagttcctaa
    73741 gggatgggaa ggtactggaa aaacttggga tgatgttcca ggtttaggtg gaagtacagt
    73801 agctcttaga ataggattta gtaacaaagg taaagggcat gatgcaataa atttagaatt
    73861 acatgaaaca gcacatgcaa tagaccatat agtattaaat gatatatcta aatcagcaca
    73921 attcaaacaa atatttgcta aagaaggtcg ttctttaggt aatgtaaact acttaggtgt
    73981 atatgcagaa gaattttttg cagaatcatt tgcatattac tatttaaatc aagatacaaa
    74041 tagtaagtta aaatcagctt gtccacaaac ttatagcttt ttgcaaaatt tagctaaata
    74101 gagttttaat aaatttaaaa taaatataaa taaagagatg ctattataat agcatctctt
    74161 ttatattgcg tttaaatcta ataaattttg tcttatgtat aactatgata gattatcaat
    74221 tactactcct tatacaaggc ttcaacgtgt ttattatgca tttgagtaat tatcgtaggt
    74281 ataatagaaa ttattgaacc aattactatc aataaaattc ctataaccat gtttataggg
    74341 ataatttctt taagtattaa taatgctagt attggagata ttactggttt aaagaagaat
    74401 actaaagatg taagactagt agatgtagct tccattgcca taaagtaaag cgcataacca
    74461 acacctgtaa caaatacgaa tacataaatc ataatgggca tattgtgtaa ggtatatcca
    74521 ctaaaaatag ggatatttgc aaatacatga agcttatttt tatttaatat atctgcgata
    74581 aaattaattt tagtgagtaa aaccaatatc aacatttcca aactaccaaa tataaagcta
    74641 aagcaggtta caactattcc accaaatttt aaggtttttc ttttaccaaa tacagtatac
    74701 attgaaaaaa taatagcaga agataatgtt aagaatattc cactaagagt tagttttgta
    74761 tgcaatggat ttattataac tataattcca agaacttcta atataagtga aattacattg
    74821 tgcctatata ttttttcctt caaaattaag taagctaaaa gcattacaaa gactggatta
    74881 caactgaaca aaacagcaac tacagatgcc tttgtgttta gaacagcaag ttgatacaat
    74941 gacatactta ctactacaca cataaaacct aaaaatgcaa agtattttaa gtctgatttt
    75001 gtaatagaaa gactaagagc tcttaatctt tttacagcaa aaggtagtaa gactaaaccg
    75061 ccaacaaaaa atcttgataa agttatttgt aagggattaa agtcattagt gacagttttt
    75121 agactaattt ccattgaact aaaaaataag gtagtcagta ttatataaac ataacctttt
    75181 ttcaagtcaa acacctcctt gtaatttata ttagtactat agataagaat attcaagcat
    75241 attggaataa tatggtatgt ataaaatata gtacataaaa ttataaacta ccttaatata
    75301 gaatgtaagt attctatact aaggtagtta attatttgaa ttactttgat ttagttattt
    75361 taaattatat aatttggcta atttttcaaa tgctggtaaa gaacttttaa ctttatcata
    75421 agatacacaa tatgatactc taaaatgacc tggacaacca aaagaagaac ctggtactaa
    75481 taataaatta aattgttttg catcattgca gaatttttta tcatcttcaa ttggagcttt
    75541 tgggaacaaa tagaatgtac cattaggttt aacacaagaa tatcccatat cgattaaact
    75601 attatataga aggtcaaaat tctttttata aatatttaca tcaacttctg catctaaact
    75661 tcttgcaata accctttgaa aaagagaagg agcatttaca aatccaagta ttctatttgc
    75721 aacatttaat gaagacataa catcatcaaa atcatccatt tgcccattag caacaatata
    75781 tcctatacgt tcaccaggta gagataatga tttactataa gagtatccta taaatgaatt
    75841 tctatagtat tttagtacac aaggaacttt ggcaccatca taaattattt ctctatatgg
    75901 ctcatcagaa attaggtata tgcttgtatt aaattctttt tgttttgaat ccaataattc
    75961 tccaagattt tttaataatt cttcagaata tatgacacca gtaggattat ttggagtgtt
    76021 tattattaaa gctcttgttt ttggagtaat agcatttttt agagcatcta aatctggctc
    76081 aaaagtctct atatttgtag gaacttctat taattttcca tcatagtttt ctgtataatt
    76141 tttatactca ccaaaatacg gtgcaaaagc aataacttca tcaccaggat ttaaaagagt
    76201 ttttaaaata atatttagac caccagcagc accacaagtc ataattaaat tttctcttgt
    76261 aagatttaat ccatcttttt tatttatgtg ttcagcaata gcatctctta catcctcata
    76321 tcctgagttg ttcatatatc catgaactaa atttggagat tcttcattta aaatatcatt
    76381 tataactgct ttaatagtct ctggaggttc aacacttgga tttcctatac taaaatcaaa
    76441 aacattttcc tcaccataaa tatcagaaag tttctttcct tcttcaaaca tagctcttat
    76501 aacagaacta tttgcaacta aagtttgcat tttattagat atcatatgta acactccttt
    76561 ttatagattt atattgctta tgtatatatt accatatttt tactgaattt agacaatttt
    76621 cgaaaaatta cttgtttgaa aatataaact tttatataaa atatatttat gtacagtaca
    76681 tattaaaaat tccaatttct aattttatca tgattatttt atataatagt tttttaaaga
    76741 attaataaaa catagattta gagaataaaa tattcttgac tatattaatt gtttaatata
    76801 atatagttga tatagtcaaa catattataa ttatagaagg gaaatttaag atggatttta
    76861 aaaatttaca gtatgaaagt ttgtcatata ttatttgtaa cttgcaaaaa aactttaaac
    76921 tttattgtga aaaatgttta aaaccatata aacttacgaa tggtctatat ttctatttaa
    76981 tttatattaa taaaaatagg aattgttctt tgaatgatgt ttctacagaa tttgaagttg
    77041 ataaagctca tacaacaaga actatatcta ggttagaaca agatggatac atagaaaaaa
    77101 tccaaaaccc taatgatagt agagcttttc agttgagagt aacagataag ggtgaggaag
    77161 tattagggga tataaaaaac atattttcaa agtgggataa tcacataaaa aaagagttct
    77221 cggatacaga atataaggaa ctggtaaaga atttacatgt ggtaaaggat ataaaaacag
    77281 ctgtggagga agaataggat gtattgtaat ttattaaaac caattaaaat tggaaatttg
    77341 gaattaaaaa atagagtatc ttttgcacct acaagcatgg gtcttaaatt ggaagaaaaa
    77401 attaaaaagt tttctgatat tgctaagtca ggagtagctc tgattactct aggagatgta
    77461 tctattagac ctagttttca taaggtagct ataagcctat cggatgaaga tggagtcatg
    77521 aaatacaaga aaattgtaga tgaaatacac aattctggtg caaaggtatc agcacaacta
    77581 ttttgttcag attatgatgt taatttaatt aaagatacta tgaatatggg aattacttca
    77641 catgatgaga taaaaaaaat aatgaatgac ggagtaaaag attacataac aaatatgccc
    77701 aaagaagaaa ttaaaaatat tataaattta tttaaagtaa cagcattgaa tgcaaaaaaa
    77761 gcaggttttg acatgattca aattcatggt gataggcttg taggaagttt ttcatcaagt
    77821 atatttaata atagaaatga tgaatatggt agaacgtgtg ataatagaag tagatttgca
    77881 agcgaaataa ttagtagtat ccgagatgaa gttaaggaca ttccaataga ctataaattt
    77941 gcaataagac aagaaaatcc tcattatgga aatgcaggag ttttactttc ggaagttgag
    78001 tattttgtta aaaaatttga atccctaggt gtaaacagtt ttcatgtaac acttgcaaat
    78061 cattcaaaat tagaagatac tataccaacc aataatcatc cttactttaa agaagaaggc
    78121 tgttttttat atttagctga tgaagtaaag aaacacacaa atcttccagt atgtggggtt
    78181 ggaaaattgt ctagcccaga ttttatagaa agtattattt caaataatag agtagatatg
    78241 gtttctatgt caagacaatt actagcagat aggaattggt tacagaaagt aaaagatgga
    78301 agagtagatg agattaaaaa gtgctgttat tgtaataaga agtgtgcaga tgctttacaa
    78361 acacgctctc agtttggatg tatactagat tagaatatcc ttataaaaat aaataatttg
    78421 ttaaggttaa tatatttttg gtgatttaga taagtattta gataaagagg aggagacatc
    78481 atgaaaagtt tagttttata ttcaagttta actggaaata ctaaaaagat tgcttatact
    78541 atatatgatg aaattcaaga agaaaaagac attaaagatg taaatgaatt agttgattat
    78601 agtattgact atgaaaatta tgatatagta ttcttaggct attgggtgga caagggaatt
    78661 tgtgataaaa attcaaaaca agtgcttgaa aatattcaca ataaaaagat agcactattt
    78721 ggaacaatgg gagcaagtaa aaaaggaagt tatggagcta gtataataga aaagatagaa
    78781 tcaattatcc caaaagataa tgaaatatta ggttcattca tatgtcaagg taagatagca
    78841 gaaggattga aagcaaaata taaagagatg ttaaaacttt ctcctgacaa cgaacatatt
    78901 cgccaacaat taaataacca tgaggaatct caaagtcatc cagatgaaca agaaatatat
    78961 gaagccagta tgtttgcaaa aaatatgatg attaaagcta gtattgtgta gtagttaaac
    79021 aataagttca tataagatat agaataaata atttagtaaa aaagtatagc aaataatttg
    79081 ctatgctttt tttatgaaat caaaaaaata ataaaaatac ttgactgtaa accttgttta
    79141 tacattattt tatagaaaat aagatagttt taaatataaa aaaagatata ttattgaaag
    79201 gagatattat tgtatgaaaa cttataaaag ataattagtt tgattttaag atatactaaa
    79261 tatacaattt tatagagtga aaatatttaa gactatatta tagttataaa ttaatagaat
    79321 agagaggtag tgtttaaatt gcaataacag tatttccaaa gttgccacct caaattccta
    79381 tccaatggaa taatggtgta gctaattatg tagataaaaa atttatttat gcctaccctg
    79441 tcatttgtgt tgtattcaga atccttttac gtccatttat atggagatgg ttacaaatac
    79501 atgcttttta tagtgacact attgcagatt atttaacgaa ttttatgtgt tttgtagcgt
    79561 tgtctataga aatattctct atacttttta tttacaatat tgccagacat gttacaataa
    79621 ttatttttat agatatactt gtatttattg ctttactgat aataggtatg tataaattat
    79681 ttaaaaaata caattaattt ttaaaaatta agtaataagt gatagtgtaa aaagtagcca
    79741 ctgcaaatta tggattgtag tggctatttt attatttgta tatgaaatta ttttgttttt
    79801 ctaataagtt acgatatatt atggtttatt tcactgataa aaggtttagg tattttaaag
    79861 taaaaagttg tatattctaa taaaatttaa acattttgat tctttaaaat tagagaaaat
    79921 acattgttct tattaaaaaa ttaaatatta agaatttaat ttctgcatct tatttagaaa
    79981 agataagaaa tcaactttat atattttttt gggccttcct ctttgattat cgagttttgt
    80041 atttacaata gttgcaattc ctgctttata taagatactc aatattctat tagcacttct
    80101 aagagttatg ttcatatagt ttgataatat ttctgctgac acattatttg aatttctatc
    80161 attaatcata cacatgattt tagatacatt tgtattagat agaggtataa aagaagcaac
    80221 tttattggct attgagctat cttcaatatt attagaattt ttatttgaat ataaagggcc
    80281 tattgtatca ttagtatcat ttactataaa agtacagttt ccattcaaag aagcagattt
    80341 accattagct tgacgagcat tttgctctgc atgaatattt gtatttccaa tgccccaacc
    80401 tatatttaag ctatatttaa tttcttttaa atcttctgaa ataaaaaaat ctgtatagtt
    80461 attggtcata ttgtttaaca tttctttagt agtgtgtatc tctattttca tatcattttt
    80521 tttgacctga actccataaa atccatgtct tgatagagaa tttaatatag tgttatatat
    80581 ttgattttgt atctcatcat ttttaaatat caaatcttca tttatgtact ctgaactatt
    80641 tactgtaact atacaagttg cagatttatt tttgtctaag ttttgtaatg ttatttcatt
    80701 caccagagat ttaaatgtat tcaggattga ttctgtagat ggaaccatgt aaatacaatc
    80761 atatccaagt ttattaagtt cacaactaat gatgtaattt ctagtaaaag aaaggttaat
    80821 cttattatct cgcaataagt ctaaatgtat ttccaataat ttatcattta attttttaaa
    80881 gtcatataca ggttgaggga tattaaaatc tttaattgta tatggacatt tattagagtc
    80941 tattaatgaa tatatatcat aataattgtt gtcctctctt aaaaaatcca taaatgattt
    81001 tgtaaagtca atatcttttt ggctatttaa taatttgaat aagtatttat aaaaatctct
    81061 ttcatcaagc tttaaaaaat ttaatggaac ttttatgtct tttatattta ttataagttc
    81121 actatatgga actataccac tgcatacaaa tccatcaaaa ttatctactt gctcatagta
    81181 tatattaggt aaattattaa aaggattctc ccctttgagc tcaataaatg taatttcaca
    81241 agtatcattt aattctttaa gagcttgttt aaacttatct gacataaaat aagatgttgt
    81301 caaaaaacca attttatatt tcataaaacc tcctttaaaa tttcgagagt atagtaacta
    81361 atcaatcaat ttataacctc attttataat agtagataaa acgcgtcaat ttattttaca
    81421 aaaggaaaat ttaaagaaaa atcagaaaat ataaaaaaga ctgaaaaata tgttgactgt
    81481 caagaataat tgtgctattt tgtaattaag gactagtctt ttaagatttc ctaaaataaa
    81541 cttagatttt aggaaagaaa tacattttat ttgaaaataa aggagaagat tatgaataca
    81601 tatttaaatg aaatttctaa gtttgttgat gagaatagag aagaaatagt ttcattatgg
    81661 aaagagattg ttaatataga aagctataca cattgtaaag aaagcgtaaa taaattggct
    81721 aagagattaa agtttgagtt tgaaaaagaa ggtttagatt gcgagttagt agatgttgga
    81781 gataatggta gtacattgat aggtacactt ggttctaata taaataaaaa gcctataatt
    81841 ttttcaggtc acatggatac tgtctttgaa acaggtacat ttggagagaa tccatttaaa
    81901 ataatagaag gaaaagcata tggcccaggt gttttagata tgaagggtgg tataataatt
    81961 tccttatatg ttattaaagc attaaataaa ataggataca aagaaagacc aataaaaata
    82021 gtattttctg gagatgaaga gataggacat aaggattcaa caggtgcaga tgttatattg
    82081 agggaagcaa aaggtggtct ttgtgctttt aatatggaaa ctggattagt agataatagt
    82141 ttgtgtgtag gtagaaaagg aagaatagga tgtaatatac atgtaaaagg tgtagaaaca
    82201 cacgcaggta atgattttga aggtggaaga aatgctatag aagaaatggc taataagata
    82261 ctacgcatac aaaaattgac taatttagat gttggaacta cagtaagtgt aagtgtgatt
    82321 aagggtggaa gagtggaaaa ttctattcca gaagattgta gtataaaagt agaccttaga
    82381 tttgaaaaag tagaagaaat ggagaatgtt aaagaacaag ttagagagat atgtaaagaa
    82441 acttacatag aaggaacttc tacagaagtt aattttataa gtgaaatgat gccatttgaa
    82501 actacagaag atgttatgag atttcataca tttgtaaatg aagtgtcaaa agaaaatgga
    82561 tttggagaat taaatgctaa gagacttgga ggtagttcag atgctagtta tttgactatt
    82621 gcaaacgttc ccgcaatctg ttcatttggt gtaagagggg aatggaacca cacatcaaga
    82681 gaatatgcag tagtagattc tatgtttgag agggtgaaat taatttctac agttatttta
    82741 aacttagata aatttgaggt ataaaggggg attttatatg gatgtaacag ctggagataa
    82801 taaggtaaca tggaaagggt atttatcttt atttgtattg atagtattat tttcaggagt
    82861 gtttaaagat agtcaaggct tccttaaagc attagatttt gctaatctga caggttcatt
    82921 tggtactatt gcagatggtg tagactttat gggtaaagga ggaacgggag caaaagatgg
    82981 tttcttattt gctctgactt tgattccaac tgtctgtttt gctgtaggtc ttatagatgt
    83041 agttgaatct atgggaggaa tgaaagcggc atcaaagata tttaatccat tgcttagacc
    83101 tctgcttggt atacctggaa tagcaggaat agcatttgta tcttcattta ctagttcaga
    83161 tgtagcctca ataatgacga aagaattatt tgaaagtggg gaaataacag atgatgaaag
    83221 aactatattt gtagcatatc aatatgctgg ttcagctgtt atactgaaca caataaatac
    83281 tcaagctcca cttttaccaa tagcattatt ggcattaggt ccaataatcc ttatagagat
    83341 attctgtaaa atacttggtg ctaatctagt tagattaatc ataggtgtaa gaaataaaaa
    83401 gaataaggct aaggaggctg tgtagtatga gtcaacaaaa tactggaaat gcaattgtaa
    83461 atagtaaacc taagaaaact gctgttgaga tatttatggg gggagcaaaa aaaggttttt
    83521 acataggtgt tgaacagata ttaccagcca tgataatggg ttatgtaata gtgcagtttt
    83581 tacaattaac tggtttagtt gatattttag gaaatatttt tggaccagta atgggtattt
    83641 ttggactacc tggggaatct gttttagttt tgatagcagc attctttgct aaggcagcag
    83701 gagcagctac agctgcaaac ttatttgcac aaggtctaat cactgcacca caagcaacca
    83761 tattaattat gccatgtatg ttaatgggta ctctagttgg tcattatgcc agaatagtgc
    83821 ttgtagcaaa tgccagtact aagtatagaa tgttactgtt ggcagttcct atatttgatg
    83881 caatagtggg gatgttaata gtaagagttt tactcactgt tatgggatta atgtaaataa
    83941 cataaaatta taacctaact ataaatgata tataagaatt aatatataca aggattaatg
    84001 agtagtaatt gatatatagt aataaactaa gatagtaatt aatgtgtata ttaattaaaa
    84061 aaagagagta tctcaaagtg aactttttag ttcatgagat actctttttg tatgaaatca
    84121 agtatatttt cataatttca acaatgaaag agaggcttat ctctattttg agacagcctc
    84181 ttcttttaaa tttatatttc tagaatttat gttttttatt tatccaacat taacattagt
    84241 tattagaaat aattttaaga aaaatatact ttcatgttaa tatcagaata aatctgtttt
    84301 taaaggatga tttgttttga attttcacga atatctactt ctatgacttt ttctattgta
    84361 tctcctctaa aacctaataa attacttgtc aagtttgcag tggaacaaga atgattaggt
    84421 ataattctta ttctatcacc aatttttata tcagtttcac catttacttt aatttttcca
    84481 acttcttctg aaagtgaatc aatagtaagt tctggatgtc cacataccct accataacca
    84541 acaatactac tatttccatg tgcaccttta tcaagtccaa ggcacttact tccacaatca
    84601 attaaatagt atccactgct attttttgag attacagtgc acacaacagt aagagcacac
    84661 atatcttcag tagcacaacc taaacctatc tgtatagcat catagtatac atagtttcca
    84721 ggtcttacag cagttatagt tttagaagca gcttcagatt caactgttgg agtactacca
    84781 gaagcgacaa tttctatatt aaatccatta tcagttagag ctttgtatgc tttctccata
    84841 gaagaatctt cttgaacaca aacatctgga acaccttctg gagaactaca accatacact
    84901 tgacctggat gcgaacttat accaacaatc tttatgtttt ctagcttaga aatttcagta
    84961 gcaagttcaa ccactttctc tggttcaacc ccaaaacggt gtaagccaca atctacaata
    85021 ataagtagct tgcactctat ttttgattta gaaaaagctt cactataagc cttagcacat
    85081 tctatattat ctgtagcaca gattaaattt atttttgatg ccatagtcac aattctattt
    85141 atatttactt ctcccatgta aggataagcc aacataatat cttcaaaacc tgcttttatc
    85201 agagcttcac cttcatcaag tgttccaact agaaaaccac tagcacctgc atttttttga
    85261 agtctcgcta tgtaagtact tttatgtgtc ttaagcatag gccaaagttg tttattatta
    85321 tttgtacaaa tttgttgaat tttatctata ttcttttcta actggtctaa atctagcaaa
    85381 aaatttggag tagcgacttc tgaaattttc atgttattta ccacctttca acaaaagtaa
    85441 attaactata agtattataa ttattatatt agtaatatcg tctttataat attaatagct
    85501 tataattata ttatagaact agcgttaaca gagagcaata tttatttgta ataattagaa
    85561 ttttcaataa gttagtgtgg ttttaaatta tttatataat atatttttaa ttttatgcaa
    85621 agtttattta aattagtttg aggatttatt aatagggtat tattgaatga gtaaaaaagt
    85681 gatgtttaca tagaataatc acactataaa ttaatttaga acctaaaaaa ttaattgagc
    85741 aaattggaaa agagaaggat aaaaaagata tttggatagt tggtggaggc gatatagtaa
    85801 aattatttat gaaagataac ttaattgatg attattatat atatatattg ccaataatat
    85861 tggggagagg gatttcacta tttaagtctg gtatagataa gactaatttg aattttaaga
    85921 aagctagtaa tattggagaa cttgtaaaat tggaatacag taaaaaacaa aaataaatta
    85981 catgccaatt tgttacaatg ttatgaaatg aagcatttaa aagacttttg gctatatgaa
    86041 ttgacattac ttgtcaaata tgttaacata taagcgactt gtcggagggt gtattaaaaa
    86101 gaatatgctg gagaagagag tgcgttaact cttttctcct ttttttataa aattaagcat
    86161 ttataaattt agtattatta catgattaca ctatctcaaa aattaagaaa ggagaaaaat
    86221 atgaaattaa ttttaagtta tttaaagaat tataagttat taatagtatt aaacatactg
    86281 gctatattta gttttgcatt agtcgagttg gggattccaa ctataatagc taaaataatt
    86341 gacaatggta ttgcaaatca gaatatagct tacataaaac aaatgggaat agtgattgtt
    86401 attatttcta ttataggggt tgtaggtagt atattgttgg gttattgttc tgctaaggta
    86461 tcaacaagtg taaccagaga tataagaaat gacatatttg agaaatcaca agaattttca
    86521 catactgaat acaataaatt tggaatttct tcaatgatta caagaacaac gaatgatgca
    86581 tttcaaattc aacaatttgt taatatacta ctaaggactg ccttattaac tccagttatg
    86641 ttcattataa gtataataat gacaattaga acaagtgtgg aactttctat agtattggct
    86701 atatcagtac cttttataat tattggagta gcaataatag caaaagtatc tcaggcaata
    86761 tcttcaaaac aacaaaaagg actagataaa ttaaacctta tatcgagaga aaatttaact
    86821 ggaataagag taattagagc ttttggaaat gatgattatg aaacagagcg atttgaaaaa
    86881 acaaatacat attatgctaa tgtttctaag aaactattta agcttatgtc aattactcaa
    86941 ccagcattct ttttactatt aaatatagct gttttggctg tattttggat ttcaagtgag
    87001 aagataaata ttggagagct tcaagttgga cagttggttg catttttgga atatcttttc
    87061 catgccatgt tttcaattat gcttttttca atggtattta ttatgtatcc aagagcagag
    87121 gtatctgcaa atagaataaa agaactttta aatgaagaac cattgataaa aaatcctgaa
    87181 aatggaatta aggatactga aaataagggt atcatagaat ttgataatgt aacttttacc
    87241 tatccagatg gagaagcttc tgtacttaag gatatttcat ttactgcaaa aacaggtgaa
    87301 acagttgctt ttataggaag tactggtagt gggaaaagta ctctaattaa cttgatacct
    87361 agattttatg atgtaacaga aggtagtatt aagataaatg gagtagatat aagagaatat
    87421 gatttaaaag ctttaagaaa aaagatagga ttcatacctc aaaaatcact gctttttact
    87481 ggtagcatag caaataatat tagatttggg aaacataagg caggagagtc agaattagaa
    87541 tattccgcaa aagttgcaca agcatatgag tttatatcaa aaaaacctag aaagtttgat
    87601 gaattgatta gtgaaggtgg agcaaatgta tcaggaggtc aaaaacaaag actttctatt
    87661 gcaagggcta ttataagaag acctgaaata tacatttttg atgatagttt ttctgcactt
    87721 gactttaaaa ctgatgcaat acttcgtgct aaattgaaga aggaaacaaa agatgcaatt
    87781 gtattgattg ttgcccagag aattagttct attattgatg ctgataagat tatagtactc
    87841 aatgaaggac aagttgtagg aatgggaact cataaagaat tattaaaaaa ctgtgaaata
    87901 tactatgaaa ttgcaacatc tcagttaaaa aaggaggaat tagaataatg aaaaagtcta
    87961 aaggttttaa gaaaacaatt ggtagacttc ttccatttgt aaagaaatat aaattttcct
    88021 ttattatagc tattatatgt ataatttcag cagctactat gaatgcactt gcacctaaaa
    88081 ctgaaggatt gataataaca caattgacta aagatgtaat tagtatcgca aaaggagtac
    88141 caggggcttc cgtaaatttt gattatgtaa caaaaatatt ggtgatttta gcatgtatat
    88201 attttgccaa tgcaattttt acgtatactt caagttttct acttaccaat gctattcaaa
    88261 acacaatgag agatttaaga aatgaagtcg aaaataaaat aagaagattg cctattagtt
    88321 attttgatag taatagtttt ggagatgtat taagtcgtat atcaaatgat gtagatacaa
    88381 tatcaaatgc attgcagcag agttttatgc aaattgtaaa ctcaatctta gtcataattt
    88441 tggcactttc aatgatgttt acaattaata tatatatggc tcttatagct ctttttataa
    88501 ttccaattag ttattttgta tctaaatttg tagtaaaaaa atctcaaagt agattttcat
    88561 tgcaacaaaa tgctcttgga aaattaaatg ggaaagtaca agaaatgtat actggattta
    88621 atgaaataaa actatatggt aaagaagaag attctataaa agaatttaaa aaagtaaatc
    88681 aagaactttg tgaaaatgga tttaaggcac aatttatatc aagtatgatg aatcctatgg
    88741 tttcattagt aacttacttt ggaattgcag ctgtggcagt tgtcggttct atatatgcag
    88801 taagtggagg aataacagta ggaaatttac aagcatttgt gcgttatata tggcagataa
    88861 atcagccact ttcacaaatg actcagttat ctacagtaat acaatcttct tttgcagcta
    88921 tagaacgtgt atttgaaatt ttagacgaag aagaggaaat acctgatgtt gaaaatccag
    88981 ttaagataga aaatgtaaaa ggaaatgtta catttgagca tgttaatttt ggatatggag
    89041 aaaattcaac tttaatagaa gatttaaatg cagaagtaaa aagtggtcag atggtagcta
    89101 ttgttggacc tactggagca ggtaaaacaa cattaataaa cttattgatg aggttttatg
    89161 atgtaaagaa aggtgctatt aaaattgatg gagtagatat aagagatatg aaacgtaaag
    89221 atttgcgttc aatgtttggt atggtgcttc aagatacatg gttatttaat ggaaccattt
    89281 ttgaaaatat agaatatggt agatttggag ctactaaaga agaaattata caagcagcaa
    89341 aagtagcaaa tgttcatcac tttataacca ctcttccaga tggatacaat atgtttttaa
    89401 atgaagaagc atctaatata tctctagggg aaaaacagct tttaaccata gctagagctt
    89461 ttatatcaga cccttcaata ttgatacttg atgaagctac gagttctgtt gatactaggc
    89521 tggaacttat gcttcaaaaa gcaatgagaa atcttatgaa tggtagaact agttttgtta
    89581 tagcacatag actttctaca attcgcaatg ctgacttgat tttagttatg aataatggaa
    89641 gtattataga gcaggggaat catgatgaat taatggaaaa gggtggattt tatgagaagc
    89701 tttataatag ccaatttgca gacaaagaat cagaatagat aacataaact tttgtataaa
    89761 attttgtatc aaattcaaat attaatcata taattaaaaa gagtatcagt aagttgtttt
    89821 tttatagatt tactgatact ctttgatttt aagaccaaag gtacttatga ttggtactta
    89881 taattcacaa ctagtcttgt tacatctgat aaccagaatt acagtacttt tcttttttac
    89941 ctttttgttc tctaacatat aacaattcgc ttaacttatc aatgtaataa ccatcatcac
    90001 ttatgcgaat taaactagtc agataatatc catctttgct tctaggaatc tttttattta
    90061 ttgctaaatc aatagctgtc tttgctgctt caaaatgctt taaatgtgta tgaccttctt
    90121 caaaactctt tctagtatta taaactacat aacctttttt aacttgaaaa actataaatt
    90181 ctttcttttc atatatttta ttaaacattc aatcagccct tctcaagata gttttatagc
    90241 ataacattag aagcttctaa aaaattttac aaagaacata aatattttat aaattataaa
    90301 tctaaaacta taatttataa agataacttt ctgattattt atatgataat tcatatagat
    90361 taaaagtaaa ttatctttag gttaaacaaa agtaaaataa aagactagtt ataatattta
    90421 tatgaaaaag tacaaaatat agtatatgaa tatagaaaat ttaaattatt tatttacagt
    90481 ttttatttcc ataagtatat ttaccttcag ataccttgtc atcatggaaa tatattcttt
    90541 cacaactttt atctccccat agaatgtttt ttgttatttt atgggacgta tctcctgtaa
    90601 atacttcagc tacagtagta tctgtaacat cacagtaaag agaagcgaat tttttaaacc
    90661 aaggattttc ctcaaatctt aaaagccagg aagctccata ggggcaatgt aactcttcaa
    90721 attcaggaac ccatcctaga aatggaacat cagttgtgct aataatattg tctgcaatta
    90781 attcatctcc attttcatga gctctctctc tcatagcaat agctctttct tcagaccttt
    90841 caaataaaac ttttcttaat atttcgctag ttttatcttc accaaactct tcaaataaca
    90901 ctttggaaaa ataaaaatat aaatcaccaa aatgtttgca tgccatacga acttcttcaa
    90961 tagcataatc tttgtcaata gtttcattag ttacaacatc ttcgttcaaa aaaatcactc
    91021 cttagaataa gtattagtta caatataatt atagaatatt ttttataaat taggaaatta
    91081 atttgagata gatatatttt taataaatga aagtataatg ctaaaataac ttattgttac
    91141 aaaaatcttc taaattaatg tatttaggag tttccatatg aatgagagta gttctgtaaa
    91201 tatcttcaat acatccattt gcaatattat taaaaatatc tgtgtgctct tttaatgttg
    91261 tttcaagcct tccttcatgt gacaatgaat cgagagctaa tttttttatt ctgtacatat
    91321 aattgttaaa cattttgtca aattcagtat tttgagcata tgaaactata gttgtgtgaa
    91381 ataatgtatc gtattctgca aatgagttta aatttttatc acctaataaa atatcttttt
    91441 gtttatctaa aagatgtttt aatttactta tagtttctac tgctctagct tctttgtatt
    91501 gacttgtaat taaaaaagta caaaatcctt ctattgcaga gcgtatttgg aatatctcta
    91561 caatttcatt tgctgtaatt tgatggattc taaatccttt gcttgggatt atatctataa
    91621 atccatcttg actaagtctt tgaagagcat ctcttatagg tgttctagag atacctattt
    91681 cactagcaag ttttgtttca gaatatattt cattttctat catttctcca gatagtatca
    91741 attcttttaa gtagtcatat gcttgttctt gtaatctttt aaatgtagcc atacttaata
    91801 atacccccct aaacaatata aaaatacaaa aacttatata attttaagca tacaacatag
    91861 tgaaaataag gtcaatcttt tgcaatttaa attgcagata agattaaaaa atataaaaaa
    91921 ttattgaagt gtgaagcatg attaacatta aaggcagatt aattaaaact aattgaaatt
    91981 agttaaaata caaaactgta aaagtagtat attatatttg aaaacaatag tatgtattaa
    92041 aacttatata ggatgactaa atataataaa tgactttaaa aattactatt tattgttaaa
    92101 ataaatactt ttatatttta tattgaccgg tatactggta tgtagtatac tctaaaacat
    92161 aaaaaacgtt ttcaaaaatg tgaagatatg gagggttata aaatgaaatt gggatttatt
    92221 ggattaggaa taatgggaaa gccaatggca aaaaatttat taaaagatgg atgtaatctt
    92281 ttggtgtatg acattaataa atctgctgtg gatgaactta tatcatgtgg agcaaaatac
    92341 gcaagtgttt tagaaatggg tcaagaatgt gatattgtat ttacaatcct tccaaatgga
    92401 actattgtgc aggatatatt gtttgggatg gatggattgg caaaaacttt aaaagaagga
    92461 agtatagtag tcgatatgag ttcagttact cctacagaat ccatattgtg tgcaaataaa
    92521 ttaaaagata tgggcttaga atttatagac tcaccagtaa gtggagggga gccaaaagcg
    92581 attgatggta cacttgcttt tatggctggt ggtaaggaag aaatttataa gaaagtagaa
    92641 ccatttttta atataatggg aagctcatct attttaattg gagataatgg tagtggaagt
    92701 gttacaaaac ttacaaacca agtaattgtt aatttgacga tagcagcagt ttctgaggca
    92761 tttgtacttg cagcaaaagc aggtgcagac ccagaaaaag tatataaggc aataagagga
    92821 ggcctagctg gtagtacaat attggatgcg aagataccaa tgattatgaa tcgtgatttt
    92881 aaaccaggtg ggaaaatatc tattaatttg aaagatatta agaatgtaat gcaaacagca
    92941 cacaatttag atgtaccact acctatgaca agtcaattat tagaaattat gcagacatta
    93001 aaagtacatg gacatttgga agatgaccat agtggaatag cacagtattt tgaaaagttg
    93061 gcaggtgttg aaataaaaaa acacaataat taatatttaa atatatcaat ataattaaat
    93121 acatattatt aggattagat tatataaata cagcgaggtt aagttatcat agtaaaagaa
    93181 aaataaaatt gataaataat aaagtagaat gataaagggg taaagattat gattacagga
    93241 tatggacttt tgatagcatt tgttatatct ataggaattt tacttgtatc gattattaaa
    93301 tttaaagtaa atccgttttt ggcattactg ataacatcta taattacagg ctttatggtt
    93361 agaatgccta taaatgaaat atcaaccaca atatcgactg gatttggaaa tacattaggt
    93421 agtataggta ttgtaattgg acttggaata atatttggaa atattctttc agaatcaaga
    93481 gcaacagaat ctattgcaaa ggggttgtta gctaagactg gagaaaaaaa cagtgcttta
    93541 gcagtaacta cagcaggttt tttaatttca attccagttt ttatggatgc agcttttgtt
    93601 ataatgatgc ctataattaa gtatgtttcg agagtaacta agaaatctct aatggttttt
    93661 gtatgtgcct taggagttgg gactatagta ggtcatgcac ttgtaatacc tacaccagga
    93721 cctttagcag ttgcagcaaa tgtaaatgca aatgtaggta gttttatact ttattctata
    93781 attgttgctt ttccagcagc tcttataggt ggatggattt atggaaaacg ttttgaaaaa
    93841 tatccagctt atgctattga tgagaatgat agagaaaaaa atttagagca gggaaaagat
    93901 agcataaaaa ttgaagatga tgattcttct aaagtaccag gttttggaat ttctatgttt
    93961 tctttattgt tcccaatact tcttatactt atatcaaatg tatttagtat gttcttagaa
    94021 aaaggttcta caatgagtgg agtacttgca tttataggag ataaaaacat agcaatactt
    94081 cttggaatat tggtggcaat aggattttta aagaaataca taaataaacc tatgggagat
    94141 gtagttattg aagctgctga ttcagcaggg ctaatattat tgataacagg gtcaggtggt
    94201 gcgtttggca gtgttataaa tgcaagtggt ataggtaact tcttagttga tactatgtct
    94261 ggtcttagta tatcagttgt agtgcttgga ttcttattaa gtgccttgct tagaatttct
    94321 caaggttctg ctactgtagc cttagtaaca acatcatcaa ttttaggacc tacaattttg
    94381 gcaactggaa tgtcaccagt tttagtaggg cttgctatat gtgctggagg agttggtttc
    94441 tcccttccaa atgattctgg attctgggta ctttcaagat ttagtggatt atcagttaaa
    94501 gatactttaa actcttggac aattggagga accattgctg gagttgtagc atttataatg
    94561 gttttattgc ttagtgttat aaatggaatt ataccacttc caggtctata aataacaaac
    94621 tattgtttat atcatataaa ttacatttag actatacaaa ttacataaag gggcgtttta
    94681 aatgagagaa gtaaaaccaa ttagcataga tatacttaat acttttaaac aagtagatga
    94741 ggacagatta aataaacttc ttgcagatga gcttaagcat ttagatagaa aaattgttgt
    94801 attagatgat gacccaacag gtgtacaaac agttcatgat atttctgttt atactgattg
    94861 ggataaggat agtatggaac aaggttttaa tgagaaaaat agtatgtttt ttatacttac
    94921 caattcaagg ggatttactg ttgctcaaac tacaaaagca cataaagaaa tttcaaagaa
    94981 tattgtggat gtatcaaaga aagttaataa ggattttata atcataagtc gtagtgattc
    95041 tactatgaga ggacattatc ctcttgaaac taatttatta aaaagcgaag tagagagatt
    95101 atcggagaag ttatttcagg gtgaaataat aatgccattt tttaaagaag gtggtaggtt
    95161 tactatagat aatgtacatt atgttaaaga aggagaaata cttgtaccag caggaatgac
    95221 tgaatttgca aaagataaat cttttggata taaatcatct gatataggtg agtggtgtga
    95281 agaaaagaca aatggaaagt acaaatctag tgatatgata tatatttcgt caaaagaact
    95341 tagagagcta aatattgaag ctataacaga aaaacttaaa aaagctgaag gattcaataa
    95401 aattattgta aatgcaaccg attatgtaga tgtaaaggta tttacaattg cgtttatacg
    95461 agcagtaaat agtggtaagg aatttatgtt tagaagcgct gctgccataa caaaaatact
    95521 tggcggagtg agtgacaagg aactacttac taaggatgaa ttagtatcaa aaggtaatac
    95581 caatggagga attatacttg ttggttcaca tgtgaataag actacccaac agttagaaga
    95641 acttaaaaat tgtaaatatc cgatagaatt tatagaattt aatcaacatt tagttcttca
    95701 agaaaatggt ctaaaaaatg aggtaaaaag agttataaaa gttgtagagg aaaaaataag
    95761 caggggtaaa actgttgctg tttatactag acgagagcgt tttgacttgg atacgaatga
    95821 taaagataaa cagcttatga tttctgtaga aatatcagat gcagttacca gtataattgg
    95881 tatgcttaat gtaagaccaa attttattat agctaagggt ggaattactt ctagtgatgt
    95941 tggtactaaa gcactaagag taaaaaaagc tacagtaatg ggacagataa aacctggtat
    96001 accagtatgg atgacaggca aagaaagcaa atttcctaat atgccatata taattttccc
    96061 tggaaatgtg ggagagatta gcacacttag agaatcagtt gagatattga tggggtagta
    96121 tattagtgta ttgaagttta aacgcttaaa tttactgagt taaaattaaa ataaactaaa
    96181 attataaatt aagattaaaa ataatagtat attaattagg gtttagagta ttttacaaaa
    96241 aatattctaa accttaatct tatgtattag tatttttatt atttaactta tgtgtttatt
    96301 ttattattta tcttttttaa ttgatttaat attttctttg attttattta aaatatctgt
    96361 atgcttatta gagcttatgt tggggaatgc tttgattata cgtctatgaa gtaatttgtg
    96421 gttagacagc aaagtattaa gtttattttt tagctcatca atacgatttt tagcatagcg
    96481 ataattttct ttttctttaa gtatttcaaa cctatcttcc aaagtatcca gtctattttc
    96541 aactaaagat tcaagtttgt tttctatagt ttcttgtgta ataagtttgt agtattcttt
    96601 cttatctttt aattccttaa ttataagatt gatttgtttt aacttaccat ttaattgtaa
    96661 aattgtatgg actgtgataa ctaaatctaa aacaaaataa atttctatag atatagcaaa
    96721 tataaatagc acatttttag agatagagtt aataaagtca accacaatag gatgtactat
    96781 aagcattaca atcaatgata atacaccaaa cataagtgag ttttccagac aaactcttcc
    96841 gtgaatatta aatttatgtt tagaataatc ccaccaagtc atattaaata ttttttctaa
    96901 aataaagctc gtacaatact ccattatgct agttataatt atactaaaca aaaacaacaa
    96961 aggaatagtg tgtacaaaag gagtcaaggt agcaactatt gctaatgctc caaatccata
    97021 tatagggcaa aatggaccat ttaaaaaacc tctatttaca aattgttttt gtaaaactga
    97081 acaatatgta gtttcacaac accatcctat aaagctataa attacaaaat aaagaaattg
    97141 aatataaaat gtactcataa gcacctcatt tctagttagt ataacactat atactcgata
    97201 ttttattttt atgattaatt tactaaattc aatttacata ttgattatac caatttatag
    97261 aaatttatca aatttaatta cagttagaac attataaaca tggttataat aatgaaattt
    97321 tatttaaaat aaataagggt gtcaagtata atcaaactaa tagttgtaga tactctacac
    97381 tatgttagtt taattacatt tgacaccctt atatttatac tatgactatt tacattcgaa
    97441 actagagcaa catgtttcaa tataaaggtt tactctatca gtttcaggag caaccaatat
    97501 attatcaagt gtacataagc taccatcttt gttgtattta caatttttta cagtacaaac
    97561 taattcctca caatttctat tattaacgtt gctagataaa ttactataaa tagattcatc
    97621 taaaaatgaa ctacaacaag tatgtctgtc attgtgagct ttttcaccat ttataaaaat
    97681 tttatctgca taacatatat ggctgttgtt atgtgaacag ttaattacat tacagtttat
    97741 tctttccaaa gttattacct cctaaacgat tatttattat aaattatgtc catataatta
    97801 caagaatata accattaaga gaaaactacc ttttagaaaa tatctattct tagagtaatt
    97861 tgaaatataa atatattttc ttctaaaatt tacctaaatt gtataaaaac ttacagcttg
    97921 gagaaaataa tagaaaaagg aggcgtaatc aatgtttgaa aagaagaaaa aagaattatt
    97981 tccttggaaa atatctgcct taatactggt tggagtattt gtattaagta gcggagttta
    98041 tatagggaca agattaaaac acaatggagt tcaaactggt gaagttgtaa gtactagtgc
    98101 gaatatgaat gaaaagtcaa aagaagcttt tggattaaat aaaaattgtg aagtttggct
    98161 tcaaagtgaa ggcgaaaatg aaactaacta taagagaaca cttacaatgg caggaatagt
    98221 tccagagtca ttattagata agacgaagtc agaaatagta tcatatttta aaaaagaata
    98281 tccaactaaa aaaataaaga gtatggataa aaatgaaatc atattggtag aatctaaata
    98341 tagtgataat aaagatgtac aagcaatgga tgttactata aaaggtaaat atactattga
    98401 aaatgataat ggaaatatag cactatataa atatgatgat agtggaagca aaacattagt
    98461 agaaaaaaca aaaataagag tagattcact tcctaaaaca gttcaagatg aaatcaaaaa
    98521 aggtgtagtt atggatactg aagaagaggc ctattcaaga ttagaagact ttgcaagtta
    98581 atagtaaatt aatattattt taagttaaat actaagtaag ttaaatacta agtaaattaa
    98641 taataaataa tttaatatta aatagattag tattaaatag attagtatta aaattgtagt
    98701 cacatttaat tcctataaaa atacaataat ttatttgtaa taaatataaa agttatattg
    98761 aggtaaaatc ttgctttgat ataacttttt tatttgattt tatattttac atagagcatt
    98821 ttatgatttg ttaatattat ttatgatata atgatttaga acataagttt ttatgagaaa
    98881 tacattttgg tatttctttt atttttaggg ggaattttaa aaaatgataa tattggggat
    98941 tgacccaggt atagccatag ttggatatgg tataattgaa tacaaaaata gcaagtttaa
    99001 agtaatcgat tatggagcag ttacaacacc tgcccatatg aatatatcga gaagattgga
    99061 acttgtgtat aaaggaattg atacaatagt aaagaattac aatatagatg aagttggaat
    99121 ggaagaatta ttctttaaca agaatgtaaa aacagctata acagttgcac aagctagagg
    99181 tgttactatg cttgcatgtg ctcataatgg gaagcctgta tatgaataca ctccacttca
    99241 agtaaaacaa ggtgtagttg gatatgggag agcagataag gcacaagttc aacagatggt
    99301 aacttcattt ttaagtctaa aaaaagttcc aaaaccagat gatgttgcag atgctttagc
    99361 tgtggctatt tgccatgctc attcaaacaa acttgaaaaa actctaaaga atataggtgg
    99421 taagtatgta tagttatata aaaggtacag tagaagaaat ttatatagac agtatagttg
    99481 ttgaaaataa tgggatagga tataaaataa atgtatcatc caatacaata atgaatttac
    99541 aagtgggaga agccacaaaa atatatacta aattaattgt aagagaagat gatatgagtc
    99601 tttgtggttt tgtaagtagg gaagaactta agatgtttga attactaaca tctgtatcta
    99661 aaataggacc taaagtggcg ctttcaatac tatcatttgc atcaccagca cagttaggag
    99721 catatatttt aagtgaagac attggaaaat tatccaaagc tcctggtgtt ggtaaaaaga
    99781 cagcagaaag aatcgtctta gagcttaagg ataaggtaga caaaaataac atagagtttg
    99841 aaccaacatt attatcacaa aaacctacct tgatatcaca agatgagtct gtagatgcac
    99901 ttgtagcttt aggctatact ttgtcggaat caaaagaggc agttcaaaaa tgtaaaaaag
    99961 atggtatgaa tacagaagct attataaaga aagcacttac atatataatg agtaaatcct
   100021 tgaaatagta tttggatttt ataatatttg gattttaaaa caatatttaa ggagtttatg
   100081 taaatttgaa aatatataaa gtagattttc aaaagtatga gaggaggggt ataaatgcaa
   100141 ggttttgaag atgaaaatag gataataact tctacaatga agatggaaga tatagatata
   100201 gaaaatagtt taagaccaaa aactttagaa gattatttgg gtcaagaaaa atccaaagaa
   100261 caacttagta tatttataga agcagctaaa tctagaaatg agcagttaga ccatgtgctt
   100321 ttatatggac caccaggtct tggaaaaact acactagcaa gtataatagc aaatgagatg
   100381 ggggtaaatt taagaattac gtcaggacct gcaatagaaa gagctggaga tttggcagcc
   100441 atacttacga atttaaatga aaatgatgtt ttatttatag atgagattca tagaatcaat
   100501 agaagtgttg aagaagtttt atatccagca atggaggatt tttgcctaga tataataata
   100561 gggaaagggc catctgctag aagcataaga cttgaccttc ctaaatttac acttattgga
   100621 gctactacaa gagctggtat gcttacaaat ccacttagag atagatttgg tgttatttgt
   100681 aaattggact attatacagt tgatgaactt tcaaaaatag tacttaggtc ttcaagcatc
   100741 ttagatgcag agatacagtc taatggagca ttagaacttg caaaacgttc aagagggact
   100801 ccaaggatag caaatagatt actaaaaaga gttagagatt ttgcacaagt cagagctgat
   100861 ggaaaaataa ctgataaggt ggcaaaagat gctctggaac ttttaggagt cgatagtttg
   100921 ggtctcgatt ttgtagatga gaagcttctt atgactataa tagaaaaatt tagaggagga
   100981 ccagtgggtt tagatacatt ggcagcttct atcggagaag atagaaatac aatagaagat
   101041 gtatatgagc catatttgct tcaattagga tttataaata gaggtcctag aggaagagta
   101101 gctatgccat tagcatatga acacttaaaa attccatatc ctaatgaaaa ataaaaatag
   101161 attatacgag tatttataaa ataaaagagt cattaaatta aaatatttct aaaatggcta
   101221 aaaattcaaa catatccaca aaatggtaat tatatctgta gatactgtgg ataaacacga
   101281 taaaaattgt gtgtattgta tctatatatt gtggataaga catgtatatc gtggaaaaat
   101341 atctatatat tgtggatatg gtgtctgtta aaaatagcaa tttcttgata gattatggta
   101401 atattgtgga aaataagttg tttttttgat attattgtag ctggagaaat tttaagagag
   101461 gaagtttaac attgaaaaca agtgatttta aatttgactt accacaggaa cttatagctc
   101521 aagttcctat agaagataga gctagctcaa gattgatggt attagataaa gagacaggta
   101581 atattgaaca taaagtattt agagatataa tagaatattt aaatccagga gattgcttag
   101641 tattaaataa tactagagtt ataccagcta gattaatagg agagaagctt gaaactggag
   101701 gtaaaataga gtttttatta ttaaaaagaa cagaggaaga tacttggcag gctttagtaa
   101761 aaccaggaaa aagagcaaaa gtagggacta aattttcttt tggaaatgga aagctaattg
   101821 gagaagttgt agatttatca gatgaaggtt caagaattat aaaattccat tatgatggaa
   101881 tttttgaaga aatattggat gaacttggaa atatgccact acctccatat atcactgcta
   101941 gactagatga aaaagaaaga taccagactg tttattcaaa gcataatggt tcagcagcag
   102001 cacctacagc aggattacat tttacagaag aattgttaaa taaaataaaa gaaaaaggtg
   102061 tagatatagc ctttgtaact ctacatgttg gcttaggaac ttttagacca gtaaaagtag
   102121 aggatgtttt aaatcacaag atgcattcag aatattatat ggttagccaa gaagcagctg
   102181 acaaaataaa tagagcaaag gaaaatggaa aaaatgtaat atgtgttggt actaccagtt
   102241 gtagaactat agaatcagct tgtaatgagt atggaaagat gaaagaaact agtggatgga
   102301 cagaaatatt tatatatcca ggttataaat ttaaagtttt agataaactt attactaatt
   102361 ttcacttacc agagtctaca ctaataatgt tagtaagtgc tatttgtgga aaggataatg
   102421 ttttaaatgc atataatgag gcagtaaaag aaagatatag attcttcagt tttggagatg
   102481 ctatgattat aaagtaggga ggtaatggat gcatagttta caaaaacaaa aaaagaataa
   102541 ccctatatta aagattgctt ttatatttga acgtgtttta gcagtagtag ttctaatagc
   102601 agtattttta ggaactatag atgttctaag acttatgtgg ggagcatata tagttgattt
   102661 tcaaaatcca gtacaataca gtcagcttaa tgatttttta gcacaaatat tacttttagt
   102721 aataggtgtt gaacttgtag taatgctatc tcttcatata ccaggagcat ttattgaggc
   102781 attactttac gcaattgcta gaaaaatgtt gctactgcct aaaaatgaag gtatgataga
   102841 tgttttaata ggagttatag ctatagcagg actatttgct ataaaaaagt ttttagtaac
   102901 aaaagacaag agtgctctta atataatgag tattcatgat gaagaagcaa ttaaggaaca
   102961 acagaacaaa gaagacgaag ataaatctat ttagacaata aattatatga atagcttatt
   103021 acaaatatat cttaagaaat aatgagaaat aaatatgatt aaggagaact ttatgtacgc
   103081 agtaagatac gaattgataa agacttgtaa gcagagtggt gcaaggttag gaagattaca
   103141 cactccacat gggattattg aaacaccaat attcatgcca gttggaactc aagcaactgt
   103201 aaaatctatg acaccagaag aattaaaaga gattggttca caaataatac ttagtaacac
   103261 ataccattta tatatgagac caggtcatga acttataaaa agagctggtg gtcttcataa
   103321 gtttatgaat tgggataaac caatacttac agatagtgga gggttccagg tatttagtct
   103381 agggccttta agaaagataa aagaagaagg tgtagaattt aggtcacact tagatggttc
   103441 aaaacatttt ctaactccag aaaaagctat ggaaatacaa aatgcattgg gttcagacat
   103501 aatgatggca tttgatgagt gtgcaccata cccatcagat agagaatatg taaaaaattc
   103561 tttagaaaga acaacaagat ggttaaaaag atgtaaagat gcccataata ataccgacaa
   103621 gcaagcttta tttggtataa tacaaggtgg gatgtataaa gacttaaggg aacaatcagc
   103681 gaaagaaata actaatattg atttaccagg atatgctatt ggtggactta gtgttggaga
   103741 accaaaacca cttatgtatg acgtgttaga gcatacaact ccacttatgc caaaggataa
   103801 accaagatac ctaatgggag ttggtagtcc agatgactta gtagaaggtg ttataagagg
   103861 agtagacatg tttgattgtg ttctacctac tcgtatcgct agaaatggaa ctgcaatgac
   103921 tagccaaggt aaagtagtag ttagaaatgc aacttatgct gaagacttta ctccacttga
   103981 ccctgaatgt gattgttatg cttgtaaaaa ctattcaaga gcttatataa gacaccttat
   104041 aaaagcaaat gaaatactgg gtgcaagatt aataactact cataatcttc actttttatt
   104101 aaatttaatg aaacaaataa gacaagcgat aatggaagat agattacttg attttagaaa
   104161 tgaatttttt gcaaaatatg gatatgaaat ataggttttg cactattaat tataatcatt
   104221 ttaatatata atattcaata gtactcaaag atagagaaag taaattgtta tataaacatt
   104281 tattatgatt tacaaaagag tataatttac aaaggagtga aaaattaatg ccacagcaac
   104341 aaataattat gagtataggt ctatgggtag tagtaatcgc aatcttttat ttcctaatga
   104401 ttagacctca aaagaaaaaa gacaaacaat taaaagaaat gagaagcagc ctaagtgtag
   104461 gagacaaggt cattacaata ggtggaatag tagctaatgt agctaaagtt gaagatgatg
   104521 ttgtaatatt agaattagga ccaaatagaa ctaaagttcc atttgaaaaa tgggctatag
   104581 gaactgttaa atctaaaaaa gaagaaatag aagaagacta aattagtaat ttaaaagcct
   104641 tttctcgaat atatattaat ttgagaggag gtttttttat gggaaaatct aattatattt
   104701 ttaaaggtct aggatatgca tatataataa ctttggctgt tttattagtg tataacttat
   104761 ttttgacatt tacagatatt ggtggagata atataactat ggtctcatca tttataacta
   104821 ctatttctgc agctatagga gggttttaca cttcaaaaca catgaaagaa aaaggactta
   104881 tgtatgggct tttagtagga cttttgtaca tagtatgtat ttttttgact gtgtttttag
   104941 cacaagaaaa gtttgtattt gaaataggga tgatttataa gttattgcta atatcagcag
   105001 caggaggcat tggaggcgta ttgggtgtca actttaaata gagtttatat taaagtagtt
   105061 ttatgatata atcaatagga aacaattaga aatggaggcg ttgaaaatgg aaaataaaca
   105121 tgtaaaaact ttatctcaag ctactttaaa gcaaagtgct gcaaaaggtg gatgtggaga
   105181 gtgtcaaact tcttgtcaat cagcttgtaa aacttcttgt acagttgcaa atcaagagtg
   105241 tgaaagatag aaaattattg atttagttgt ttgtaagagg gtatctcaaa gtgattcttt
   105301 tatcattatg aggtatcctc ttttattttc aattattata taaaaatata tattctattt
   105361 atgtagaagt aaatttgatt tcttatcgtt taattatgca aaaatatcta atcatgtaag
   105421 agcatttatt ttaaagtagc tactcttata ttttattttt tatcaattac atgtattaga
   105481 ataattttta attttaaact ctaatttatg atgattttta taatatgtta tatattttaa
   105541 tatatggaga tagatattaa tttagtgata tatatttaag taataagagt aaagcaaaaa
   105601 ttagtgcata gtagtatata aaaatggagt ttgaatactt ttgttagtat atgattgttt
   105661 agtagaaaat cactataaaa taggatttct atctttgagc ataattatag agagcctaag
   105721 tagggggaag ggtttcaaga agatattatt agtgtttgtg ttagtaaatt atgtaaacac
   105781 ataaaatata ttgaaaaata atattatata taatattatt tatgtgtggg aaatacgaat
   105841 ataaaaaata aaaaataata ttcggaggac ataaatatgt taagcaacaa aaagagaagt
   105901 atggcaatag taatggcagg tgctacagtt atgagtgcag cagcaccaat attcgcagac
   105961 aataccgtga cagaaaatgt tgataaaaat tacacagtaa gtgcgaaaga ttctgctaaa
   106021 ctaatcgaag aggttagaaa agcattagaa gttaagtttg aagatacaaa agcaggagca
   106081 aatgtaaatg atagagttta cgatataaaa gtagacaatg taaacttaac taatgcaact
   106141 caattacaaa ataaaataaa ctctttaaca gaagggcaaa gtttaaaagt tactattcaa
   106201 gataaagggc atcaagtgtt aggtggaaaa gtagttgact ataaaattga aaactacaaa
   106261 actgctcaag aaatagtaga tgcagttaat gcttacaatg caactttagc agaagattct
   106321 gataacaagt taacagcaac tataaaatct acaaatacag ttgaagtaaa aagagcaaaa
   106381 gattcagcaa atgttattac attaaatgta ggagaccaac atttagattt ctcaaaagtg
   106441 ataacatcag aagaaggtac ttttgaaggt tatgaaaaga gttatagtga catagattca
   106501 aaagaattac atacgataac agttaaaaac gcagatttac aagacatatc agcagaagaa
   106561 ttatttgatg gaattagatt aactacatta ggaagagaaa tagttaataa agttaaaaat
   106621 ggatatgctt taacatttga aaatgaagca atccttactc aagaacaaga agatagtgat
   106681 gataaagata aaccagaaaa atcaagcttt gatatagttt taagcaaggc aaatgaaaag
   106741 ccagaaacaa taagtgtttc aagtaaaaac cataagttag ttagagactt acacaaagta
   106801 ttaactgatg taaaagatgg aaaagaatta aaagtagaag ttttatctgg tgattcaaga
   106861 tttacaacag cagtagaagt tagtaaagag agatttaaag atggagaagc agaagctata
   106921 attttagttg gagaagatgc tatagttgat ggattagcat cagcaccact tgcctctcaa
   106981 aaaaatgcac caatattatt atctaaaaaa gattcactac catcagaaat agaagctgaa
   107041 atattaagag tacttggaag taatctatct tctaagaaaa tatatatagt aggtggagaa
   107101 tctaaagtat caaaagaaac tgaagaaaaa ctttctaaat taggtgtaag taaagttgag
   107161 agagtttctg gagaagatag atttgaaact tctttagaaa tagcaaaaca attaaaagat
   107221 acatttaaga ctgcttttgt agtaggtgga aatggagaag ctgatgctat gagtatatca
   107281 gctagagctg ctcaatttgg tgctccaata atagttacag gtaacgaatt agatgcaaat
   107341 gctgaaaaat tattaaaagg aaaagaatta gaaatagtgg gtggagaaaa ttctgtatca
   107401 aaagaagttg aagacaaatt agttgatata gatttaaata ataaagttga aagattagct
   107461 ggagaaaata gaaaagatac taatgctaaa gtaatcaata aatactatgc aggtgcaact
   107521 aaagcatatg tagcaaaaga tggttatgta ggtggaaatg gacaattagt tgatgcactt
   107581 acagcagcac cacttgcagc tagttcaaag gctccaatag tattaactac agaagaactt
   107641 tctaaatcac aagaagaagt agttgagtta agacttaaga atgctactaa gttagtacaa
   107701 ataggtgaag gaatagctaa aaacgctatt gaaaaaatag cagaaaaaat aaacttattt
   107761 actaagaact aataagatat aggaattaat attaaaagtt tatttagata atatatgatt
   107821 atacaatgcg ttaatatgta agacatagtg tagatattat aaaatataca aataacaaga
   107881 taaaataata aaaataaggt gtctcattta gaattagatt gagatacctt attttatttt
   107941 ttgattataa tgttgagaaa ttcatattgc aaaaattatt ataaaaagat acttcttata
   108001 atgattaaac atattactaa cataaattat tttgaactta taacgtaatt aaataaaata
   108061 aattataatg ttttgaattt atagagaata aaaactttag gtatattgtt tgagttgtat
   108121 ggataactat ggtatcatat ataaaatatg gtaacaaaat tgtaactttt gattaaaaat
   108181 aagtatgagt actaataaaa aatatgaaaa gtacattggg ggtagaaaat aatatgaaga
   108241 atagtaaaaa gatattagct ataggactta cactattttt agtaatggta aatactccta
   108301 tggtaaatgc gttgacatca gttgagcaaa taaaagggaa tgacagatat gagacagcag
   108361 caaaaatagc agataagcaa aactacaata cagcaatact aatcaactca gataatagct
   108421 tagcagatgg tctaagtgca agtggtttag ctggagcctt aaatgcgcct attttgatga
   108481 caaaacaaaa ccagattcca aacacaacta tggaaagatt aaacaaagca aagactgtgt
   108541 atataatagg ttcagaatca acaataagta aaaatgttga gaatcagtta ctatccaaaa
   108601 agaaggttgt acaaagaata tttggtgaaa atagatttga tacaagtata aaaatagctg
   108661 aaaaaatcaa agaaattaag ccaatagata aagtaattat agccaatgga tttacaggag
   108721 aagcagatgc gataagtgca tcaccagtag ctgctagaga tggagtacct ataatactta
   108781 cagatggaaa tagtgtggga tttgacacga caggcttaaa gagttatgcg cttggttcta
   108841 gtgaaataat aagcgacgaa ttagttaaga gcacaaattc tattagattg ggtggcacag
   108901 atagatttga aactaataag atagttatac aagagtttta taaaaatagt aaagaatttt
   108961 atctaagtaa aggcttacaa ttaacagacg ctttggctgc ctctacaata gcaaaaaatg
   109021 ctcctgtagt tttagttgaa aatggcagta acaagagtat tttaagtggt gcagacaaat
   109081 tgactgtact aggaggcata aatcagaatg ttatcaagca atgtataaat caagcttcac
   109141 caaatcaaca aggtttatat tacaatccaa atgatagagc atttaaagag agaataaagg
   109201 gtaaagtata tgctcttaca aagcagtata gaaaagagaa tggagtaaga gcgttatctg
   109261 tagcaagcag attagagggt ctagcaaatg attggtctaa tttaatggca aataagaaga
   109321 ctttatctca tacgataaat ggaaaaaatt catattctac ttttttgaaa tacttagatt
   109381 ggagtgagat taaacctgga tatatagcag ttcaaggtga aaatataatt aaatataaaa
   109441 ttccagataa acctgtatat acaaatagag atgcagatga tataggaaac tttattttta
   109501 atgagtggaa gacaaatcca gaagaaggaa ctaatatgtt gcataaaggg tatgaaataa
   109561 tgggatttgg tatagctata acaggagata agaatctata tgctacacat gaattttatg
   109621 gaagatataa agaataagaa aatatacaca aaattatgct tgtaaggaag ctatataaat
   109681 aattaaatta taatggaaaa tagcatttat attaataaat taatataaat gttatttttt
   109741 tataatttaa tctaaaaaaa ttatattaaa aagtttaaat atagtataaa atgggtaaga
   109801 aagtagtgaa aattaaatgg caaaattagg gaaatctaat gacgcaaaac tatagggatt
   109861 aaagctttta aagccatatc agccagttgc taaaaagagt aaagtctttt tattttataa
   109921 ttaagattct ctttgagtgt ctttttttat tgtctgaaac ttatagtatt taaattcatg
   109981 aaaaattaga tatttattaa gggaggattg ttatttcatg aaaaaggcaa tatcttgtgt
   110041 actagcagta tctatgtgta gtgcaccact aaacgttttt gcagaaccta tattagaggg
   110101 gaagctaagg gcagttgaaa aatcagttac agaaaagtta agggggagtc ttgaagtaga
   110161 tttaaatttt tcactgccaa taaaaaatag cgagtcagaa agtatgacta atatgcagtt
   110221 acgattaaaa gatgatagta acaatagtgg aataataaag cttggagaaa aagattcagg
   110281 aacagtaaat gttgggacag ataatataga atatactata aaaaaattat ctgcaagtag
   110341 aagtgaaata aaaaataaag atgagaatat atcatattat aatattgtat ttaataattt
   110401 acctgttgga aaatacaatg tagaagtctc tggagatgga tttaagaaca aagaaattaa
   110461 agacattgat atatcaagtt attcacaaag agtcttatta agcaatagag caagtgtaga
   110521 taataaaaat aaacctttaa attatgaatt gttcttaatg ggtgatgtaa atggagacgg
   110581 taaagtagat aagagtgatt ataataaggt tttagagaat atagattcaa ataaaagaga
   110641 atttgattta aatagagatg gaaaggtaga tattgttgac ttagattatg tacagaaaaa
   110701 tttaggacaa agtgaagatg caaaaagcct agaaagtata gtatctacca atcctatagt
   110761 agatacaagt aaggttgaat taaaaggaaa tagtgatgta gatattaatg gtaatgtaga
   110821 aaatttattt agtggagaaa ataatggagt tacaatatct tcaaaaaatg atgaaatatc
   110881 tgaggaaaaa ccagcagtaa tggatatagc tttatcagaa gcacttaata tggaagtcat
   110941 caatataaaa gctccagaag gtactgctcc agcaaaagga atagttgagg ttactgacaa
   111001 agatggtaat gttcaacaga ttccttatga aaacaaagaa tatatgaaaa acttaaaaga
   111061 tgaggagcaa caagaggaag taaataacga acaagaagaa gtaaatcaag aagaagtaaa
   111121 taataaagat gaaaatataa accagactga taataactca aataataaag atgaaaataa
   111181 tgataaacaa caggaaaata gcgataaaca agaagcaaac tctaatacca atcaagataa
   111241 aaataatgat aaagaaaatt catcaatgga taaacctaat tcagatgaag atactccaaa
   111301 agaagagggt aatatcagta aagatgataa ctctacaaca tctacatata gtaggtcagc
   111361 attagaaaca tatgcagatg ttcaaaatag tgatatagta ataaatcttg gtaaacaagt
   111421 agcagtaaaa aagataacta taaaaataac agctacaaca gcaaacgata gaaatcttgc
   111481 agaaatatca aaagttgaat ttttaaacaa tgtatataaa gaaataccaa agccagagat
   111541 gaacatacct aaaataaata aaatatcgac tagcactgct gttggaaatg aaaaagtatc
   111601 tttttattgg aataatgaag taaatgtatc agcatacgaa cttatactag acaaaattga
   111661 tagtaaggga aaagtattat ctactaaaaa attacaaact agtaaaaata caatagaagt
   111721 tagagatata gaagcatatg gactatatag agttagcata caatctttaa atggagattg
   111781 gtctagtggt tataaagatg caacaccaga aaacttagac ggagtaccag aaaatgtaga
   111841 ttcaaactat aaacctatac aatttagccc agatagtata ttagaatttc aagttgttcc
   111901 agacacaaaa ccagaaccac cagaaggtat aaatgttaaa ggtaaattta aatctcttga
   111961 tgtaagctgg aaaaatcata aacaagctaa agattttgac ttgtactata aagaaaaagg
   112021 ctctaatggg tcttggataa aatacaatga taagcttatt cgtgggacaa gttcaaagat
   112081 agaaggtctt aaggataata caacatatga agtcagaatg acagctacta accacttggg
   112141 aactagtgga atgtctaaaa catatatagg tacaactgaa agcatggatg caccaacaac
   112201 acctaactat agattaatta atactcctaa agaaaatggt ggatttggaa taccaacaaa
   112261 tcacattgta gatgttgttt atccagatgg atatgacaaa agtgaatata gtgataaaaa
   112321 tccatttgat aaattcaatg tagtagatgg ggactttaca acacattgga cattcccaac
   112381 atataatgca gctgagggaa cgaatagagg accaataata acttttgata aatcttatac
   112441 tatggatact tttatggcta cacctcgttt tgatgtttct gataagacaa taaatgactt
   112501 tgaggtacga tattgggatg aaaatggtca attacacaat ctgggggatg ttccttttga
   112561 aacaaagaca gaccctgtaa ataataataa gtatgtaatg gttagattaa aagaaccaat
   112621 aactgctacc aagatacaag taagtgtttg ttcatcctat tcatataagt ctaatatatc
   112681 agaacttaag ttttatgagt atgacagtat agaagatgat gtaagaaatc tatttatgga
   112741 tggcctacaa gttgaattaa aagaagatgt aactcaagaa aaaataactg aattaaaaga
   112801 tagattaaat actccagata aagctagtgg agaatatcat ccatataaga cagttattga
   112861 gagagaatta aaattagctc aagacttata taatgataga gccacactta ctgatgtaac
   112921 tactgtaaat caagaaataa ataaattagg aaaatataaa gataaaaacg gacagtatac
   112981 tgtaaattcc aataatttag gtatgcaaaa tgactggcag gcattaggag tagctgctag
   113041 agcaggagat gaaatcacag tatatgttgg aagtaaaagt ggaaaaactc ctaagttgat
   113101 atatacacag tactatggag aatctggtgc atataagagt ggagaaataa atcttaacac
   113161 tggaaaaaat gtaattcaat taagcaaact tcatagttta gatatagaat gtggaggaag
   113221 tttatacata agatacgctg aagatactcc aagtggagga gatataaaag tacgtgtagc
   113281 aggagctact aagataccac atcttaatct aaatggaaca ataaatgata agagtcctgc
   113341 gggagtttct gaatctaaga aaaagataaa agcatatata gaagaattag ctaaatataa
   113401 agatgctgta aaaggagaac catattatcc aggaacaaat gttggtaatt catatggata
   113461 ttcagaaaaa actggtgtgt taaacactac agatattgaa agtgataaag taacattaaa
   113521 tgttcctgca acagcagtat atcaagagat atcaaaagga aattctgatt taaatacaca
   113581 agtagataga ttatataata gtatgcttgc atgggaacaa ataatggatt tagtttactc
   113641 agaaagagga gtatttaaaa cacaagattt agatggtaat ggaactgtag atgataatga
   113701 atttaactta actaaaaatg atatggctcc aaaatctcgt atgaacataa aataccaaag
   113761 aatgtttatt ggagcattta tgtatgcttc tggattacat gtaggagtag aatatggttc
   113821 agttccaggg cttatgaatg gagtaccttt ccaaatagat gatagtggaa aagctacagg
   113881 aggaaactta tttggatggg gaataggtca tgagatagga catgttacag atattggaaa
   113941 gatgacatat agcgaaacta gtaacaatgt acttgcttta cttgctcaga cctttgatga
   114001 taagacacat tcaagacttg aaggttcaac aatggataag atatatgagc atgtaacttc
   114061 aaatagctta ggtataccaa gcaatgtatt tgaaaggctt ggaatgttat ggcaattaca
   114121 tctagcttat gatgatgatt ttacgggttc aatgttaaag aataactcag atgctgattt
   114181 aagtaatgat acattctatg caaagatttc aagaaaatac agagcacttt caagtagtga
   114241 cccaattaat agtttaccaa aagaccaaat gctagtagca atggcatcaa gtgttgttga
   114301 aaaagattta agagattact ttaaggcatg gggagtagaa attacaccag aattaaacag
   114361 tataatggat agcaagaact acgaaaaaga atcaagaaag atacaatatg taaatgatga
   114421 agctagaaga aagattttaa atgaaaatat agctagtatg gcaaaagata ctaaagtaag
   114481 tgctagtttt tctgatggaa tacaaagtgg ttctctagtt aaatctaata aaatatctat
   114541 agacctagat gtagataagg ataaagataa gatactagga tacgaaataa taagaagtga
   114601 tggaaattat ttagatggtg aaaatggaac acaggtaaaa tacagaacag ttggatttgt
   114661 ggatgcaaaa ggaaatagca agactaaatt tactgataat atatctcctc ttaataacag
   114721 agcatttaca tataaggtag ttgcatatga ttatcaccta aatccaacag aagaatttga
   114781 agttggtact gtaaaattat cagatgaagg gaaaataaat aaatcagcat ggtcattcat
   114841 aacaaatact gtttctgacg gtgatgttag aactgaaaat gactcacatg gaccattaca
   114901 aaatcctgaa attgataata taaaagataa tgatgcaagt actacatata aaggaaagat
   114961 aataagtaaa gcagagtgga acaaagaccc tcaaaaagac cctgatataa atgtagaaga
   115021 aaatccatat ataatagtag acatgaaaga aacattacct atagtaggac taaaatatac
   115081 aaaaccagag acagaagcta gaaagttctc attaaaagga ttatttaact ttagaaagaa
   115141 tactagcaca acatacaatc ctttaactaa ttacaagata caagtaagta atgataaaaa
   115201 gaactgggaa gatgtaagtc aaggaacttt tgaatatgga caagatttag ttggtggagg
   115261 aaaagaccaa gataatgaag ctagagttac atttaataaa gatggtaaac tttggacata
   115321 ccaagctaga tatgtaaaac taatctcaaa taataagtct aatatagaag ttgcagaatt
   115381 agatataata ggacctccag gtgataatat agaaattggc ataataaata atgcagacga
   115441 aactcgtact aatggaattg gaaaattagc agaagattat gtatatcaaa gtgatgactc
   115501 tagcacaagt gaagatgaaa caggtaagat tccagcgggt tcaatagtta ttacaggtga
   115561 atacagtgga aatccagcat ttaatttacc actacttata gataaaaaca ataagactat
   115621 atctggagaa gcacttttat ttgcagaagt tccagaaaaa ggtgaactag gtgaaatcag
   115681 taaaggtaca tgggtttact atatgccaaa agaaaacttt gattctttaa gtgataaggt
   115741 taaggctgaa ctatatagat acaatgacct tcaaggagat actccagtag gtcaaagatt
   115801 tgtaagtgat acaatgtatg tacctgtagg agctaagaat tatgatgagt taaagacaat
   115861 aagtcttact gatagtaata gtaaagctag aaaagctaca agaaattcta ttgatatcag
   115921 taataagaag gttataactg taagcaataa agtaaagggt aatattgtta gagataaata
   115981 gtaggtggaa ctctaaaaac gtaaaaatac taacattgta tatctaataa gattaggtac
   116041 tagaatagtt ttaaaatagt agatattaaa agtaaagtat ataaatgtaa ccataaattt
   116101 agggtaattt ataaattaaa tataaaagct aggtggataa gtaaatttat ccacttagtt
   116161 aatgatagat aaggacgggt gttaatgagt aaaagaaaat cttttataag aactatagca
   116221 gtatcaacta tggcagtagc tgtaactggt agtgctacat gtgcatatgc agctccagtt
   116281 ttacaaggaa caaaaacgta tgagaaagta aatactatag atatatctgt ggactcagta
   116341 gaaaacatag tatattcatt tcaagccagt ataaaagtac aaggtgaggt tgaagtagta
   116401 gataatgagc agaaagaaaa gattacttgg tctgataata taaaatctca gataaaaagt
   116461 ggaaatgcaa atgctacttg tagagtagaa tacaacaaat caagtaatac aactacatta
   116521 gatatatatg ttacatcaaa tgaagattta ctagacggaa atagattgaa tataggaaga
   116581 atatctgtaa aaaaatctgg cagtaactca aatgctgact ataaagtttt aggaaaagga
   116641 acaaatgata aaccagcttt aaaaattgta acatataaca acaaaacagt ggattatgaa
   116701 aatataagct ctgatgaagg attaatattt acccttatta atgagagtga agtaaaacca
   116761 attggtggaa ctggttctag taaaaatgac cctgaaaagt ataaggtaga gaaaagtgaa
   116821 gcacttgaat atttattaaa caatattagg ataaactatt ctattgttag taaagaaaca
   116881 caagaaagtg gttcaaatgt aatattaaaa cttggattag cacaaaaaac aactaaggga
   116941 agaaaagcta caataaacaa atatgttgaa gttacacttc caaaaagttt agaatacata
   117001 gttgaaaatg aattatcaaa accggatgaa ttaccaccag ataatggcaa tggtggaaat
   117061 aatggtggag gaagtaattc aggcggctca tctagtggtg gaagctctgg aggaggaagt
   117121 tcaagtgatt ctacatctaa tgtcacagtc aaaaaattaa aaggtgctga tagatttgag
   117181 acagctatca aaatatctca aagtggttgg acaaaatcag atacagttgt aatagtaaat
   117241 ggagaagata aaagtatggt ggatgggctt acagctacac cacttgctag tgtaaaaaac
   117301 tcaccaattc ttttatcatc aaatgaaaag cttcctcaaa aaactgtaga agaattgaaa
   117361 aggctaaatc catcaaaagt aattgtgata ggtggaaaca actcaatgcc aaattcagtt
   117421 gttgaagcta tcaaagctgt aaattcaaaa atatcagtac aaagaatagg tggagataca
   117481 agatatcaaa cttctattaa tatagcaaaa gaaatagata agacgaataa tgtaagcaag
   117541 ttgtatatag gagcaggaaa tggagaagct gattcattat caatagcatc actggctggt
   117601 aaagaaaaaa ctccaatagt acttacacaa aaagatggtg tagataatga agctgaacaa
   117661 tttattaaat caaataaggt gtcaaatata tattttattg gtggagtaga aaaaatatct
   117721 aacaaggcta ttgaacaagt tggaaaaata gcaaacaaag atatatcaaa caatagggtg
   117781 gcaggtcaaa ctagacaaga gacgaatgcc aaagtaatag ataaattcta ctctcaatct
   117841 aagctagatg gagttgtagt tgcaaatcaa gataaactta tagatgcttt agcagttgga
   117901 ccattagcag ctaaaaacaa ttcaccagtt atacttgcta caaatacgtt agataaatca
   117961 caagaatcgt cattaaaagg taaaaattca tcaaagttgt ttgaagtagg tggaggaata
   118021 gcctcatctg taatagacaa gattaagagt ttaattgaaa aataaatatt aagtaaatag
   118081 aaaataagaa tgtatttaga tataaagtta tatatttaaa tgcattctta ttttattttc
   118141 attatcttaa caatctaata atattgaggt taaaatgtat aataatttga gctatattaa
   118201 gtttaatttt aaataaagca gatatctttt atatatataa atataaattc aattttgaat
   118261 atgtttaaaa agaagttaaa aataattttt taaatttaat aaaataaaac actaatatat
   118321 agacgagata tattcatatc atatatactc tataatatat ggaaaataaa gagaaaataa
   118381 atggaaaata atcacaatat aaatataaaa tataaaaatc atcaggggga tatgaaaatg
   118441 aacaaaaaaa tattatcatt aggtctagca gtatcattaa tcttagtaaa cttcaaaagt
   118501 gtaaatgcat catcagtagt agaaaaaata tacggtaaag atagatatga aacagcagca
   118561 aagatagctg ataaacagac ttatgaaaca gtaattttag taaatacaga aaaatcactt
   118621 gcagatggat taagtgcaag tggattatcg ggagctacaa aagctccaat actatttaca
   118681 caacaaaata agataccagc agacacaaat agatgtctaa aaaatatcaa aaaagcatat
   118741 ataataggta cagaagatac tataagtaaa tcagtagaaa aagaactaga ttctaaaaat
   118801 atagaagtca aaagaattgg tggagaagat agactaaaaa caagctattt aatagctaaa
   118861 gaaatagcaa ctataaaaaa agtggataaa gtactattaa ctaatgcata tagtggagaa
   118921 gcagatgcaa tgagtgtatc atcagtagct actagagatg gagctccaat catacttaca
   118981 gatggaaaga gtgtgccttt tgatgtaaaa aatattcaat catattgtat aggttcagag
   119041 gagataatga gtaatcctct agttaaaaat acaaactcag taagaataga aggaactgac
   119101 cgatttgaaa ctaacaaaaa cgtaatagac tactttttta atagtgcaga tggattctat
   119161 gtatcagatg gataccaatt agtagatgca atagcagctg caccacttac taaaaactct
   119221 ccaatggtac tagtaaatga tggaagcgat aaaactgtat tagaaggagc taagaatata
   119281 acctctgtag gtgaaataaa tgagaaggta atacaacagt gtataaatgc ttcaaattca
   119341 aatgggcaac ccccaacaat tacagttgga agtacagagg tatataaggg tgaaaagttt
   119401 gacactggca agttaaatat agtagctaaa gataacacag ggaaggtatt accaatagaa
   119461 gttgatgggt ttatagatac aaatagagta ggtacataca tattgacatt aaaagctaca
   119521 gacgaatggg gaaaaagcac aggaaaaaga gtagaaataa aagtgttgga tgacaaatct
   119581 catgattaca acagcccaga atttaaaaaa atggtatcta ctgaaatgta taacttaatc
   119641 aattcctata gaaaagaaaa aggcaaagag cctttgctag tgtctagtag gctagaaggt
   119701 atggcaaatg catggtctaa gtatatgatg gataaaaaag tatttgcaca ttatatagat
   119761 ggaaaaaatg ctccacaagt attttctgaa tttggaatga gaagtgagga aaatatagca
   119821 tatatttata tagattctaa gaacgttcaa acgacacaag atgcaaaaga cttggcaaag
   119881 gctatatttg aggtgtggaa gaagtctcca gagtacaatg caaacatgct tagtaatgag
   119941 ttttatagta ctggatttgg gctttatata ttatctgatg gtcaagtgca tgctactcag
   120001 gagtttttaa atggaaatga aggtagcttg taaaaaattc cataaatctt gtttttttgt
   120061 taatttactg atattataaa atgaaaatca catctaaagt actttttgta atctgttttg
   120121 ttattgcttt acaggctatg gtattttagg tgttttttgt tttagtagtt tatagatttt
   120181 gagggaatca ctactgagga tgtaatttat gattagctga attatataaa aaaattagta
   120241 ggaggagttt gatgaaggta aataagagag tattatcaat aggattgaca atatcattaa
   120301 taatggcagg agcaccaaat atcaatgcac tttcgagcat agaaaagata caggggaaag
   120361 atagatatga gacttctgca ttgatagcag ataaacaaat atatgataca atcatattag
   120421 taaatactga taattctata gtagatggat taagtgcaag tggattatct ggagttgcaa
   120481 aagctcctat aatgttggtg caaagagata agataccaac agatgttgaa aaaagactaa
   120541 aggatgttaa gaatgcttat gttataggta cagaggatac aataggtaaa tctgtagaaa
   120601 atcaacttaa gaataaaggg attgaagtta aaagaattgg tggggaagat agaataaaga
   120661 ctagctatct tatagctaag gagatttcag ctattaaacc agtaaatgat ggtgataagg
   120721 tttttcttgt aaatggatac acaggtgagg ctgatgcaat gagtgtatct tctgtagctg
   120781 ctagagatgg agttcctgtg atacttactg atggaaagag tataccattt aaagttgatg
   120841 gcgttcagtg ctattctctt gggtcagagg agataatgag taatgaactt gtgagtaaga
   120901 ctaattcagt taggattgct ggtaaggata ggtttgaaac taataagaag gttatacaac
   120961 gcttttataa aggaacaaag aagttttatg tttctcaagg gtataagtta gttgatgctg
   121021 tggctggttc tccgttggct aaggacaaac ctatagtact tgttaatgat ggaagtgata
   121081 agagtgtgct tagaggtgct gatgaagtta cttctttagg tggaatggat aagaaggttg
   121141 ttgaccaatg tattagttct gcatctgata aaaatacaat gcctacaatt actgctaatg
   121201 atgtagagat ttctgtaggg gataagtttg ataatagtat gttgaatata gttgctactg
   121261 attattatgg aaatgattta aaggcaaata ttaaaggaaa tgttgatatt aacaaggctg
   121321 gaacatatgt tttaaatata agtgtagtgg ataatttagg tcagaagagt gagattagtg
   121381 taaatgttaa ggtagttgta aatgcgagta caaaagactc taatagttat gagtttaagg
   121441 ctatggtatc taatgagatg tatgatttag ttaattcata tagaaaagaa aaaggcaaga
   121501 agagtttaag agagttagac tctttagctg gaatggcaaa tgcatggtct aaatatatgg
   121561 aagataagaa ggtatttgcc catgagattg atggtaaaaa tgcagctgaa gtattttttg
   121621 gctttggagc aagaagtggt gaaaatattg catatctacc aatgaatgtt aaatctgttt
   121681 atacttctaa agatgcaaaa gaaatggctg agtctatttt tgatttatgg aagaagtctt
   121741 ctaagtataa tgaaaatatg ttaaaagaag aattttatag ctttggattt ggtatgcatg
   121801 tttctagtaa aggagaagtg aatgcgacaa tggaattttt aaatagttag attttatatt
   121861 aatttacatt ggaaaagata tagtaaattt gtaaaaataa atatataaaa ttaaaataac
   121921 ttataaaatt ataaaaaata atttaaaaat aataaaaatg atgaaaaaac aattaatttg
   121981 ttggaaaaaa cttcaattaa ttttgcataa attattgaat ttatatttta tatagtctat
   122041 cataagagtg tgagaaatat ttggattata tgaacatgga aatttaatgt acataattaa
   122101 agagatgtaa ttaatataat gttgggagga atttaagaaa tgaataagaa aaatttagca
   122161 atggcaatgg cagctgttac tgttgtaggt tctgctgctc cgatatttgc tgatactact
   122221 gttaaagaag aaggatatac ggtagtacaa gacaaatatg aaaaattact taaagaatta
   122281 aaggcaaaga taaaagatgg aactattaca tcagttggtg ttgaatttga tggaaaacca
   122341 attactacat tagcaccaaa ggcagatggt agtgataaag atgcaatagc agaacagtta
   122401 gaaactctta ctaaaaacca acttaaaggt ttaggtgatg gaaaatatgt agattttaaa
   122461 attacttatg gtgctaaagc agaagttcca gctgcttcat taagtgcaga tgatatacaa
   122521 aaatatgcag atcaaataaa tgcttctgag aaaatattag ttgaagtagc agcaggatct
   122581 gaagcaggta tagcaaaatt tgattctgtt aacaataaag ttatagcagg agatgctcct
   122641 cttaaagtta aagatgcagt gaaagcgact gttactacta atggtagtaa taaaaaagtt
   122701 cttacaatat cagctgcagc tggattatca ggattttcat atggaacact taaagacaca
   122761 ggtgcaagtt catctgatgt tgatgcaata actcttgaca ctacaaatgc aacaataaca
   122821 gaaggtgata ctaaagtatt agattttgat aattcattta agtttaacga aagtactaaa
   122881 aaagttggta gtttagttac accaaataca acaaacactc cagcagatcc tggtactaaa
   122941 actactgtta gagtgataaa agctgttgaa aaaacaatag atgtaagttc aaattcaact
   123001 acaaaagcta aagatttagc taaacaatat gtattcacag atgttagtga tactgatcca
   123061 gaaagtttaa gttatatgct taaaaacata aatgatggaa aagttgctgt taaaaattct
   123121 gatggagatt atgaagtaac tatattccca gaaggaaaaa gattaaatac tttatctgct
   123181 tcttcagcta aaactatttt aggagataaa gatactccag caaaaatagt tttaaaggct
   123241 tcaacaacaa agaaattagc agactatata gatgatttaa taacttataa caatagttat
   123301 tcaaatgtac aaactgtagc aggtagtgat agaatagaga ctgctataga gctaagccgt
   123361 aagtactata actctactga caaaaatgct ttatatggag atcctgtaaa taacgttgta
   123421 ttagtaggtt ctcaagctat agttgatgga ttagtagcat ctcctttagc agcagaaaaa
   123481 gatgctcctt tattgttaag ttctaaagat aaattagatt catcaacaag agctgagata
   123541 aaaagagtta tggacttaaa ttcttcaaca ggaataaaaa ataataaaga agttttcata
   123601 gcaggtggag taaattctat atctaaagac gttgaaaatg aactaaaaga tatgggactt
   123661 aaagtaacta gattatcagg tgatgataga tatgaaactt cattagcgat agctgatgaa
   123721 atagatataa atgataaagc ttatgtggta ggtggaacag gattagcaga tgctatgagt
   123781 attgctccag ttgcatctca aataaaagat ggtgaagcta ctccaatagt agttgtagat
   123841 ggaaaatctg acaagttatc taaagaagct gaagatttct tagatgatgc acaagtagat
   123901 ataatcggtg gagaaaatag tgtttctgct aaaatggaag attatataga tgatgctact
   123961 ggaaaatctc cagaaagaat tagtggtgct gatagacaag caactaatgc tgaagttata
   124021 aaagaatact ttgataaaga tggagtttca aattacttct tagcaaaaga tggttcaact
   124081 aaagaggatc agttagttga tgcattagca gcagcagcag tagctggaaa ctacggttct
   124141 aagcataatg aagatggaga tataactaca gatgcttctc ctgctccaat tattttagca
   124201 actgataatt tatcagctga acaacatgta gctgtaagta aaactgctac tactaatggt
   124261 gctaagaact tagtacaagt aggtcaagga atagctgatt cagttgttag caaattaaaa
   124321 gatttattag atatgtaata taaattttat atattgaata aaaaaggttt ctcttttgag
   124381 aaaccttttt tattttaaac ataaattttt ataaataaaa agaggctaat tagcctcttt
   124441 ttaatgtgag aaacacttaa aaaataagat gtaattattt atttaagtat cattattata
   124501 ctatacctta aaataaatgt ctactattct ataattttaa ggtataatag taagtggaaa
   124561 ataaataagg aggtaaatta aatatgtcag ttttagatgt aatattagac aaaacagatg
   124621 aattagaaat taaaaaatta aataatatag tagataaaat agatgcttta gaagataaaa
   124681 tacaaatact agatgatgaa gcattaaaaa atatgacgaa tgtatttaag gataagttaa
   124741 gtaaaggaga aaccttagat gacatattgc cagaagcatt tgctgttgta agagaagtat
   124801 caaaaagaat attaggtatg cgtcaatata gagttcaatt aattggtggg attgtattac
   124861 atcaagggaa aatagcagag atgagaactg gagaaggaaa gactctagta ggagtagctc
   124921 cagtttactt gaatgcattg actggtaagg gggtacatgt catcacggtt aatgattact
   124981 tggctcaacg tgataaagaa cttatgcaac cagtatatga atttttaggt ttaacagtag
   125041 gagtaattat taatgggcaa cagccagtag aacgaaaatt acaatatcaa tgtgatatta
   125101 cttatggtac aaacaatgag tatggattcg attatttaag agataatatg gtaacgcaaa
   125161 aatcagagaa agttcaaaga gaactaaact ttgctatagt tgatgaggtt gattcaatac
   125221 ttatagatga agctagaaca ccacttataa ttgctggtgg aggagatgaa ggtactaagc
   125281 tgtatgaact tgcaaatgct tttataaaga atataagaga tgaagatttt gaaatggata
   125341 gaaaagataa aaccatagca cttactgcaa gtggtcttag taaagctgag aaattttttg
   125401 gaatagaaaa tataactcat atagataata tagaaatttt tcaccatgta aatcaatctc
   125461 taagagcaca taaattaatg aacatagatg ttgaatatgt tgttagagat aatgagatac
   125521 taattgtaga tgaatttaca ggaagaataa tggatggaag aaggtttact gatgggcttc
   125581 atcaagcaat tgaagctaaa gagggagtaa aaataaatga tgaatcaaag accatggcaa
   125641 cagtaacatt tcaaaatttc tttagattat actctaaatt atcaggaatg acaggtacag
   125701 caaagacaga ggaaagtgag tttgaagcta catataagat taatgttgtt cagataccaa
   125761 ctaataaacc agttataaga gctgatttac atgataaagt attcaaaaca gaacgtgcaa
   125821 agtacaatgc tgttgtagaa gaaataataa ggataaataa aactaagcaa ccagtgcttg
   125881 taggaactgt ttcaattgaa aaatctgaga aattatctaa gctacttaaa aagaaaggtg
   125941 taaagcacga ggtcttaaat gctaaacaac atgataagga agctgaaata atatctaaag
   126001 ctggtaaatt aggttctgtt acaattgcta ctaatatggc aggtagagga actgatatat
   126061 cacttggagc tggagataaa gaagaagaag aaaaggtgaa agagttaggt ggcttgtatg
   126121 ttataggtac tgaaagacat gagacaagaa gaattgataa tcagcttaga gggcgttcgg
   126181 gaagacaagg tgaccctgga acttctagat tctttgtaag tttagaggat gaagtaataa
   126241 aattgtatgg tggaaaaagt atagaaaaaa tattaaagag aatgaatgct aatgaagatg
   126301 acgcgttaga aagtaaggct ttgaatagag caatagaaag agcacagaaa ggcattgaag
   126361 gtaaaaattt tgaacaaaga aagaatgttc ttaagtacga tgatactatt aatgagcaaa
   126421 gaaaagtaat atatgatgaa agaaataagg tattggatgg ttctgatatt gaagaagaga
   126481 tacaaaaaat ggttatggat attattacgg aggctgctga aaagtactta aaaaaattta
   126541 gagactatca tggatatttt aagtatttat ataatacttt tatgccagct gatactttat
   126601 taattccaga cttagataaa aaaaatgttg aagaaatagt aaatcaaaca tatcagattt
   126661 caaagcgtgt ttatgatctt aagaagatga tgattggaat tgaagaattg gctcaattag
   126721 agaaacgagt attacttcaa gttgtggata cttattgggt tgaccatata gatgcaatgg
   126781 atcaactaag acaatatata ggtcttaaat cttatgcaca aaaagatcca tttaaagagt
   126841 atgctataga aggttatgaa atgtttgaag ctttaaatag gaatataaga ataacaacag
   126901 tgcaatatct atataaattt aactaaaaaa gtgacccatt gggtcacttt ttatatatta
   126961 agattaaagt gaaatttatt ttacagtaca cactcatata gataaatatt tataataatg
   127021 aaaaagaggc tgaacgtcag cctcttttcc tgtgtgagaa atacggaaaa aagagatgct
   127081 tgaaatttct ttcttccatt taatattata ctataaagag aataaaaagt ccatgagtta
   127141 tctttatgat taaaaaaaaa aattacaatt ttgttacttt ttagtataca ataataaatt
   127201 taaattgact ttgttaattt ttattaataa aatatccaaa tattacaata tctacagttt
   127261 attgaaataa tgtgtaaatt atattataat tggtaaataa ggaaaaatgg tgaaaaccaa
   127321 attttgtagg gggaaatata tgaatagaaa aaatctttat gtaattatgg cagctgcaat
   127381 ggtaagtaca tcagtagctc caagttttgc tgcagaagct acacaagtaa agaaacaaac
   127441 aataactaaa aaggaagcaa cagaattagt ttctaaagtt agagaactaa tggctcagag
   127501 atatacagga ggttctcaag ttggacaacc aatatatgaa ataaaagttg gtgaaacttc
   127561 atcacaatta aaaataataa ctaatataga cgaattagag aaattagtaa atgctttagg
   127621 agaaaataaa gagcttcttg tgactatagc agataaagga catacaacaa atagtgcaaa
   127681 tgaagtggtt gctgaagcaa ttgaaaaata tgaaaattca gcagaccttt cagctgaagc
   127741 taattcaata acagaaaaag ctaaaactga agctactggg atttatggag tggcaactgt
   127801 agaagcttca tatgacagta caaaagataa gttagtaata actttaaaag ataagactga
   127861 tgtagtaact tctaaaacgc tacaaatagg tattggtgat gaaaaggttg atttaacagc
   127921 aaatccagtt gatatagcag gaaccaattt agacccttct gcagaaggat ttagagtaag
   127981 taaaataaat aaattaggtg tagaaggagc taaaaatatt gctgatattc aattagctga
   128041 aataactata aaaaatagtg atttaaatac agtttcacct caagatttat atgatggata
   128101 tagattgact attcgaggta atacaatagc aaatagtgta ggaaaatcaa ttagtgatat
   128161 ttcatcaaaa gattcagaga caggaaagta taaatttact gttaaatata ctgatacatc
   128221 tggaaaagcg atagaactta ctgtagaaag tactaatgat aaagagttaa aagatgttaa
   128281 agatgcctta aatggaaata caaaagtcaa tttaatagct ggggaagaca ggtatgcaac
   128341 tgctgtagct atagcaaaag aaacagaata tactgacaat atagttatag ttaattcaaa
   128401 taaattagtt gatggattag cagcaacacc actagctcaa tctaaaaaag ctcctatatt
   128461 gttggcgtct gataatgaaa taccaaaagt aactttagat tatataaagg aaataattaa
   128521 aaaaagtcca tcagctaaaa tatatatagt aggtggagaa tcagcagtat caaatacagc
   128581 tagaaagcaa ttagaatcag taactaagaa tgttgaaaga ttggctggag atgatagaca
   128641 tacaacttca gtagcagtag caaaagctat gggttctttt aaagaagcat ttgtagtagg
   128701 tgcaaaaggg gaagctgatg ctatgagtat agctgctaaa gctgctgaac ttaaggctcc
   128761 tataatagta aatggttgga atgatcttac agcagatgct atcaagttga tggatggaaa
   128821 agagattggt atagttggtg gttctaataa tgtacctagc caaattgaaa atcaacttgc
   128881 tgatattgat aaagatagaa aggttcaaag agttgaaggt gaaacaagac acgatactaa
   128941 tgctaaagtt atagaaacat attatggcaa attagataaa ctatatatag caaaagatgg
   129001 atatggaaat aatggtatgt tagtagatgc attggcagca ggtcctctag cagcaggaaa
   129061 aggaccaatt cttttagcta aaaatgatat aacaaactca caaaagaata ctttagataa
   129121 aaaactaaat cttggtgcag aagtaactca aataggtaat ggggttgaat tgactgtagt
   129181 tcaaaaaata ggcaaaatac taggatggta ataatcaata atatagaaaa ggattcctta
   129241 ttatttatag gaatcttttt ctatcgacat aatattcatt aaagtataac atgctcttga
   129301 cagataggag gatatgatag tgatagaagc aacattgttt ttttccccac accaagatga
   129361 tgaaacatta agtatgggta gtgcaataat tgaacatgta gaaagaagcg atacacatgt
   129421 tatattatgt actgatggca gtaaatcaat aataagaaaa gtattagatg atggagggtc
   129481 atgttcttat catattaaag atgtacacaa gtactcttta tcagaaagtg atttttcaaa
   129541 aaatagagat gaagaattta aaaatagttg taaagcaatg ggagttaaag aaaataatat
   129601 acatatagaa aataatagag ctcatgatgg agaattgagt aaggaaaaag caagagatat
   129661 aatgctaaaa tatttagaaa aatatcctga tgctaaagtg aagaccgtta caccatataa
   129721 agctcttgga atacatgaag accatagagc attaggtgaa gctgcattag aattgtatag
   129781 agaaggaaaa ataaaagatt taagatttta tgtagagcca tacgattata atgattttaa
   129841 aaaagttaat ccaaatgtta gagtatggaa ggttttgagt agtcaagaag agaaattatt
   129901 aaatgctatg gatgcataca agaaatggaa tcctgaaaat ggtaactacg caattggata
   129961 tcattctgta aaatctcact ttgatgaatt aaaatccaat aaaatccaat atgtacatgc
   130021 tccataaaca ttaatataaa aactaggagg atatagttaa tgaaaatatc taagagaata
   130081 atgtcgttgt tgacagcaac tttttttatc tttgcattat ctatcaatat agctgatgct
   130141 tcatcaaaag agagtctagt gggctctggt agatgggaaa ctgcaataaa aattagtcag
   130201 aatggatgga aagatgctac taatgctata ctagtaaatg ataattctat agctgatgca
   130261 ttatctgcaa ctccatttgc taagttaaaa gatgcaccta ttttattaac tcaaagtgat
   130321 aaattggata gtagaactaa agcagaatta aaaagactag gtgtaaaaaa tgtatattta
   130381 attggaggta tgaatactct aagcaccaat attgaaaaac aattaaaatc agaaaatatg
   130441 acttttgaga ggatttcagg taatagtaga tatgaaacat ctttaaaatt agctgaaaga
   130501 ttagataaag agaagagtat ttctgatata gttgtagtta atggagagaa agggctagca
   130561 gatgcagtaa gtgtgggttc tgctgcagca caagaaaata tgccaattat actttcagat
   130621 cctaacaatg gaataaaagt tgcaaatagc tttattagta gtaaaaatat aaagaaatct
   130681 tatataattg gtggtacata ttctgtatct agttctattg aacagagttt acctaatgta
   130741 aaaagattat ctggaaacaa tagaaatgaa actaatgcaa aggttctaga agaattttat
   130801 aaaaatacag acttaaaaaa tgcttatata actaaagatg gtatgaaaaa acagggggat
   130861 ttgatagatt ctctagctgt aggtgtattg gcagctaaaa atagctctcc agttgtatta
   130921 gtaggaaatt cacttgactc tagccaatat gatgtgttaa atactaaaag ttttgataat
   130981 attgtgcaag ttggtggaaa tggaaatgaa gatgctgtaa aggatattct tgatttacaa
   131041 gaagaaacta tatatagagt taagacagca gacgaattgg atgttgctct aagaaaagca
   131101 gatgctaatg atattataac atttaaacct gatgataata aaaaaattac tagttcattt
   131161 agtatagaaa caaagaaagc tataactgta gagcttgaag gattgtatac acaaacaata
   131221 actgtaaata tgccaaatgg agaattaact aataagggta cattagatgg aactgtgaaa
   131281 ataatggata taaaaaatgg cacatttatc aatgaaggtg atataaatga tattgacatt
   131341 tatgatccaa atggatgtaa aatagagaat aaaagtggtg gagatatatg ggttttaact
   131401 atatctagta gtgctaaaga tgtaaatata gaaaataaag gtgatataag taaggttaca
   131461 aataattcta ctagcgttat aataagaaat tcaggaaata ttgatacttt aagtggaatt
   131521 aatgcaccag caataagtgg aaataaacct agagttgatg ataccgataa ggatgaaaaa
   131581 agagcaagtg gaatatatcc tacttcagaa cctttatcac ctgcaagagc tggttatata
   131641 agtgtaaaaa tattcactaa gcctgaagat acaaattata aaatttatta tagagtagta
   131701 agcagtagac catctgcatt atatatcgga gatagaatag atacaagtga ctggactgct
   131761 gtaccatctt ctgttttacc atttactatt aaagcagaaa atggatatta tatagaagct
   131821 gttgaaataa attctgatac taagaaagta tctagatggg ggaaatctga ctatatagat
   131881 gatggatttt atttaaaatc agaaactgca aaaggattaa gtgcagatat agattttgat
   131941 ggagattatg ttaaattaac agcaacaggt gctgattctg gatgtacagt ttattataga
   132001 atagtatcaa aaaagccagt atcaatgaat gttggagata aagtaactat atctgattgg
   132061 gatgaaatta ctactaatag agtgaggata gaagcaaacg atgtaaagga taaatatata
   132121 gaactagttg aattggatga ttcaactaat aaagtaacta gatggggagc aagtgataag
   132181 gtagtagaat aggtatctaa tgtgaaacat aaaaacagac tgattaataa tgggcagtct
   132241 gtttttattt cctaaaaatt atcattttac taaataaata atttaaaact ataacaatta
   132301 tattagtaaa tacttttaca gtaatatcat ttacaaaaaa taaatcaatc attatataca
   132361 taataatcat ttctataata ccagaaagta gcctaaaact gacaaaaaac aaaaactcct
   132421 taaacaaaaa tattagttca attcttttac tctcaaacac aaaaaactta ttagtaacat
   132481 aagcaaataa aacagcaagt atccatgcca aagcatttgc aaccataaaa ttaaataaaa
   132541 taactctagt aaaaaataaa tacgaaacta tatttacaag agtagtaaat gctccaaaaa
   132601 ataaatataa tatcgtctct ctatgctttt ttaaaatcaa atataatcct cctaagctaa
   132661 tttaatataa atatacttaa agatactaac aaacattagt ataacacatc tattaataaa
   132721 tcaatatatc ttaaaatatt ataaaaataa aactataata ttctataatt aatatgtact
   132781 cataatccat attttatcaa aataaaatat gaccttaatt tagaaatctg atataataaa
   132841 aattaaatac atataagggg gtaaacatga gaaagtacaa atcaaaaaac ttgtcaaagc
   132901 tactagcatt gttgacagtt tgctttttaa tagtgtcaac aatacctgtc tcagcagaaa
   132961 accataaaac tctagatgga gtagaaactg cagagtattc tgaaagctat cttcaatacc
   133021 tagaagatgt caaaaatgga gacacagcaa aatataatgg agtaatacct tttccacatg
   133081 aaatggaagg tacaacactt cgaaataagg gtagaagtag tcttccatca gcatataaat
   133141 caagtgtagc atacaaccca atgaatcttg gtcttactac accagcaaaa aatcaaggaa
   133201 gtcttaatac atgctggtct ttttcaggta tgtcaacgtt agaagcatat cttaaattaa
   133261 aaggatatgg aacgtatgac ttatcagaag aacatttaag atggtgggca actggtggaa
   133321 aatatggatg gaacttagat gatatgtcag ggagttcaaa tgtaacagct ataggatatc
   133381 tgacagcatg ggcaggtcct aagttagaaa aggacatacc atataatctt aaatctgagg
   133441 cacaaggtgc aactaaacct tcaaatatgg atactgcacc tactcaattt aatgtaacag
   133501 atgttgttcg tcttaataaa gataaggaaa ctgtaaagaa tgctataatg caatatggtt
   133561 cagtgacatc aggttatgca cattattcaa catattttaa taaagatgaa acagcatata
   133621 actgtacaaa taagagagct ccattaaatc acgctgtagc gatagtagga tgggatgata
   133681 attattcaaa agataatttt gcatctgatg taaaaccaga atcaaatgga gcatggttag
   133741 taaaaagtag ttggggagag tttaattcta tgaaaggatt cttctggatt tcttatgaag
   133801 ataaaactct actaacagat acagataact atgcaatgaa atcagtatca aaaccagata
   133861 gtgataaaaa aatgtaccaa cttgaatatg ctggtcttag caagataatg tcaaataaag
   133921 taacagcagc aaatgtattt gattttagca gagactctga aaaacttgat tctgttatgt
   133981 ttgaaacaga ctctgtagga gcaaaatatg aagtatatta tgcaccagtg gtaaatggag
   134041 ttcctcaaaa caattcaatg acaaaacttg caagtggaac agtatcatat tctggataca
   134101 taaatgtacc tactaattct tacagcttac caaaaggtaa aggagcaata gtagtagtta
   134161 tagacaacac agcaaatcct aatagagaaa aatcaacttt agcatatgaa actaatatag
   134221 atgcatatta tttatatgag gctaaagcaa acttaggtga aagctacata cttcaaaaca
   134281 ataagtttga ggatataaat acatatagtg aattttctcc ttgtaacttt gttataaaag
   134341 ctataacaaa aacatcttct ggacaagcta cttcaggaga atctttaact ggagcagata
   134401 gatatgaaac agcagttaaa gttagtcaaa aaggatggac ttcttcacaa aatgcagtat
   134461 tagtaaatgg agatgcaata gtggatgctt taacagctac accatttaca gcagcaattg
   134521 actctccaat tcttttgaca ggaaaagata acttagattc aaaaactaag gcagagttac
   134581 aaagattagg aactaaaaaa gtttatctaa taggtggaga aaattcttta agcaagaatg
   134641 tacaaactca acttagtaat atgggtatat cagtagaaag aatttcaggt agtgatagat
   134701 acaagaccag tatatctcta gctcaaaagt taaatagtat aaaatctgtt tcacaagttg
   134761 cagtggcaaa tggtgtaaat ggacttgcag atgcaataag tgttggtgca gcagctgctg
   134821 ataacaatat gccaataata cttactaatg aaaaaagtga gttgcaaggt gctgatgagt
   134881 ttttaaattc atctaaaata actaagtctt atataattgg tggaacagct actttatcat
   134941 caaatttaga aagtaagctt tcaaatccaa caagacttgc aggcagtaat agaaatgaaa
   135001 ctaatgctaa gataatagat aaattctacc ctagctcaga tttgaaatat gcttttgttg
   135061 ttaaagatgg ttcaaagagt caaggagact tgatagatgg actagcagta ggagcattgg
   135121 gtgctaaaac tgattcacca gtagttctag ttggaaataa gttagatgaa agtcaaaaaa
   135181 atgtacttaa gtctaagaaa atagaaactc ctattagagt tggtggaaat ggaaatgaaa
   135241 atgcttttaa tgaactaaat actcttttag gaaaatagtg aatggaaaga tagtaaggat
   135301 atacatttta ttattaaaaa atgttcaata gaagtttata aatataaaat aacaaaaagg
   135361 ggtgtctcaa aatgaacttt ttagttcatg aggcactctt ttttgttgtt ttatattttt
   135421 atcatttaaa taatgaaaaa taggattgtc tatattttta gatagttttc ttattattga
   135481 tgaaaaatgt aataatttta aactgtaaaa tagtgtaaag ttattttata atataaatat
   135541 agtaagattt taaacaaaat aagggggaat aataatgaaa gcaccaaaaa ctattttaac
   135601 aatactgaca atagcgctta ctttaagtag catttctata ataccatcat atgcacttac
   135661 agaggaaaaa ttaataggta atggtagata tgaaactgct gtaaagataa gtcaaaaggc
   135721 atacagttct agtcctaatg tagtgctagt taatgacaat tcattagctg atgcactttc
   135781 agctacacca tttgcaaagg ctaaaggagc accaatactt ttgacagaaa gtgataagct
   135841 agatgatagg actgaaaaag agataaaacg tctaggagct aaagatattt atttgatagg
   135901 aggtactgct gtacttaata aagatataga gaacaagtta aaaagtaatg gacttaatgt
   135961 agaaagaatt aatggtaagg atagatatga aacttcactg attttggcta ataagcttaa
   136021 ggatataaaa gatattaagg aagttgctgt agtaaatggt gaaaaaggat tgagtgatgc
   136081 tgttagcgtt ggggcaccag cagctcaaaa taagatgcct ataattttgt ctagtcctaa
   136141 ggatggagta gaagcatttg ataaatttat aagggatgag aaagttataa aagcatatgt
   136201 aattggaggt acaaattctg tttcaagagc tgtagaaaag agtcttccta atgcagaaag
   136261 agtgagtggg aaagatagaa atgagactaa tgctaaagtt atagaaaagt tttacactga
   136321 tacaaattta agtaatttat atgtaactaa ggatggtagt aaaaatgaga atcaactaat
   136381 agactcgtta gctgttggcg tattggctgc aaaaaatgag tctcctgttg ttttggttgg
   136441 taataaatta aacacaaaac aaagagatat acttagtact aaaaaattaa atactataac
   136501 acaggtaggt ggaaatggaa atgaagaagc ttttgatgaa attaaaagtc tacaagaaaa
   136561 aactgtgttt gaagcaaaaa ctgttgagga attaactgat atgataaata tagcaagtcc
   136621 taatgatatt ataaacttta aaccaaaaga gaatactgta aatgaagctt ttagaatggt
   136681 aacaaataaa ccaataactg tgaatataaa gggtgattgt tcaaagactc ttacagtaga
   136741 tatgcctaat ggtgaagtga ataactatgc tactttggta aatgttatag ttagaaatat
   136801 tggagaaggt ggatttaata atcatgatac aatcactata ttgtcagttc gtgacaaaaa
   136861 tggtagagtt atagaaaata ctagaaattc agatatagat acgttgatga tattagcttc
   136921 tgctaatgat acaaaattga ttaatgatgg atatatagga aaacttatag ataattcatc
   136981 taatagtgat ataactaata atggtactat agataaaaaa gttaatcagg ttgaagattt
   137041 agaggctaaa gtagattcaa ttgaaaaagc tatagattct ataagtcaaa aagtcaataa
   137101 aatacaagat atactagata agcttggatt tctaaagaaa tttcttagct aagaatatgt
   137161 atatttaagt gaagtgtgtg ttgtaattgt tctaaagtta tgtagttaaa caggtttata
   137221 tacaaataga tttatagata aatatgtagt ttagtatata tttgaataag ctttggggag
   137281 gtaacatggg gattggaatt gaatgtaaca aaaaaataaa taaaagtatt gacaaaacta
   137341 gaataaagaa aaataatct
//
LOCUS       DAEPID010000002       108801 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.002, whole genome shotgun sequence.
ACCESSION   DAEPID010000002 DAEPID010000000
VERSION     DAEPID010000002.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 108801)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 108801)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..108801
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.002"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            452..1483
                     /locus_tag="KR257_000105"
     CDS             452..1483
                     /locus_tag="KR257_000105"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012816405.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="S8 family serine peptidase"
                     /protein_id="HBH0028837.1"
                     /translation="MENICDMNNKVKVAVLDTGIDKEHDYLKDNLVGGIAFECMHDYI
                     FISDKFDDEDGHGTACASIIKKEYEDVELFVIKILRKDGITNIKVLEEALRYLLDTNI
                     RLINLSLSVIGVESVKGLFEVCYELFRKGKIIVCSLANDFDLSYPAMFNNVIGVRGFT
                     LDGDDSFWYNKKYDVQCVMDSNSYISCDINNSYRLPPKCNSYLSAKLTGKIAKILSEK
                     PGITISDLNDKLESLATRNHWDSCDFDECSRIVNFKLDLYDKENALFMKVADVVRDCL
                     DIEENNEKLFKGSLFNKEIGLVYDNCFNLLKKLEHRFDIKFNYMDISKYDLVSIYTLT
                     ELVERYKNL"
     gene            1616..2914
                     /locus_tag="KR257_000106"
     CDS             1616..2914
                     /locus_tag="KR257_000106"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903674.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional folylpolyglutamate
                     synthase/dihydrofolate synthase"
                     /protein_id="HBH0028838.1"
                     /translation="MKYEEALEYISQTNKFGIRLGLENIGKLLELLGNPQETLNIIHV
                     AGTNGKGSVCSFVSNILRECGYKVGLYTSPYLETFTERIRVNGQNIPQDDVARIIELI
                     KEKIEIMVKEGYAYPTEFEVVTAMAFYYYSEQKVDFVALEVGLGGRYDATNIITKSLV
                     SVIVSISLDHTGILGDTIEKIAYEKAGIIKENGVVLVYDQTDEAKDVIKSVCKEKKAK
                     YIEVDFDDINIKKSDINSQIYDCTVMKETYRDLEIKLIGEHQINNSILAISVIKYLKD
                     INKLANINEESIRKGLINTKWPGRIEKIKENPIFIIDGAHNEDGAKSLAKALDKNFKG
                     RKLTLLIGMLEDKDIDSVLEILLPHFNKVITTTPSNPRAINSDILREKVLKYVDDVTS
                     KHEIEDAVNYTLETSSEDDIIISAGSLYMIGTVRTLVKKL"
     gene            complement(3028..3273)
                     /locus_tag="KR257_000107"
     CDS             complement(3028..3273)
                     /locus_tag="KR257_000107"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891710.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TIGR03905 family TSCPD domain-containing
                     protein"
                     /protein_id="HBH0028839.1"
                     /translation="MKVTFNPSGVCCREMIFEVDENNVIVDAEFIGGCNGNLSGLRSL
                     IIGQNALEVADKLNGIDCGGKGTSCPDQLSKAIRQSI"
     gene            3421..4287
                     /locus_tag="KR257_000108"
     CDS             3421..4287
                     /locus_tag="KR257_000108"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422120.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YncE family protein"
                     /protein_id="HBH0028840.1"
                     /translation="MKIYISNYLSKSISIVDYSTLELEKEIVLEDNIYPHHFCIEKEK
                     NLIYIPSSSNGILYVLDLSNDKIIDTVSIGGSLSQVVLSDNELFVANEDSNSIYVLDK
                     NTLNPIGIIGVDNMPHGFDFDRESKKLYVPCINSIVCIDTINKNIQKKINMDFRAWHI
                     ELDKQKKEMYISTLDGKLIIIDEVSMDIKKVLYEFLLPVEIRFNYSGKKVYVADLGYN
                     NVRILDYTTSRYIGNIEINGIPQGLEISKDEKLLFVSDTQENSVKVYETANNKLIKEI
                     KVGKEPTTIICL"
     gene            complement(4291..4827)
                     /locus_tag="KR257_000109"
     CDS             complement(4291..4827)
                     /locus_tag="KR257_000109"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891708.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4364 family protein"
                     /protein_id="HBH0028841.1"
                     /translation="MFENSSEELAYHKLLILYILEKIKMDLTNSQITQVVLETEMMNY
                     FSLQQLLSQLMESKFLTTYKDSDREYYALTQRGVESLEYFFNRIPTSVTEKIDKYIDS
                     NKENLLADTQVKSSFVKQSDNEFIVNLRVIENQSNLIDLNLNVSSEKQAKLICNNWKN
                     NASYMYAEVIDLLIRDIH"
     gene            complement(5018..5221)
                     /locus_tag="KR257_000110"
     CDS             complement(5018..5221)
                     /locus_tag="KR257_000110"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422115.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha/beta-type small acid-soluble spore
                     protein"
                     /protein_id="HBH0028842.1"
                     /translation="MSNSNRTVVPEAKAALNQMKLEIANEIGLSNYENIDKGNLTARE
                     NGYVGGYMTKKLVEMAERQMAGK"
     gene            5512..6276
                     /locus_tag="KR257_000111"
     CDS             5512..6276
                     /locus_tag="KR257_000111"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891705.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="polysaccharide deacetylase family protein"
                     /protein_id="HBH0028843.1"
                     /translation="MKREVKRTKALIYSVLFFSLLLVLIFVFVYGIKYICSKSDNSKM
                     PIYKVDTNEKKIALSFDVAWGTDNMDDILKILDKHNVKATFFLVGSWVDDNEEIVKAI
                     DEKGHEIGNHSNTHANLKEISKEDITKEIETTSEKIYNITGKRTNLFRPPFGDVNNKA
                     MDICSDLGYKVIKWDVDSIDWKELGPNHVIEKVIKESQPGSIVLFHANINDVDNYLDT
                     IISRLKKDGYSLVKISDLLYKDNYVVDSNGVQKTKN"
     gene            6665..7978
                     /gene="prdC"
                     /locus_tag="KR257_000112"
     CDS             6665..7978
                     /gene="prdC"
                     /locus_tag="KR257_000112"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003431873.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="proline reductase-associated electron transfer
                     protein PrdC"
                     /protein_id="HBH0028844.1"
                     /translation="MNKLYSILLKQHVGGPDKPVVSVGDVVKKGTLIAEPTGLGANIY
                     ASVSGKISEINDQAIVIEADEVQEDTFEPLKGEGILDLIKEAGVVGMGGAGFPTHVKL
                     NIDLNGGTILANAAECEPLLAHNIKEIEERPEIVYQGIKYAMEVTNAGKGMLAIKSKH
                     PKAIEAFKKVIKPGDNIEVAELVDMYPMGEERAIVRDVLGKLLEPTQLPSEANAVVIN
                     VETLTRIVEAVEQKRPVISKNITVVGQLNSGKESIVFEDVPIGTTVGELIERAGGIKG
                     EYGEIILGGPFTGKATTLDAPITKTSGGIIVTMPFVNEKRKMGLLVCACGPNEERMRD
                     IATKMGVTDIVSVQKCKQAQEIKGALKCENPGHCPGQAQKCIEFKKAGAEVILIGNCT
                     DCSNTVMGSAPKLKLGVYHITDHVMRTVNHPLIRRIKGDVRLKIK"
     regulatory      8382..8467
                     /regulatory_class="riboswitch"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF01786"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="cyclic di-GMP riboswitch class II; Derived by
                     automated computational analysis using gene prediction
                     method: cmsearch."
                     /bound_moiety="cyclic di-GMP"
                     /db_xref="RFAM:RF01786"
     gene            9049..11298
                     /locus_tag="KR257_000113"
     CDS             9049..11298
                     /locus_tag="KR257_000113"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898383.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Cys-Gln thioester bond-forming surface protein"
                     /protein_id="HBH0028845.1"
                     /translation="MKTKIKKSSIISLVIAFSMVFTAFTPIVSYADEVTSNDTILNGE
                     EQSNGQTSDVEKPSDGQVPDGEKPSDSQVPDVEKPSDGQVPDGEKPSDSQVPDGEKPS
                     DGQVPDGEKPSDGQIPDGEKPSDGQIPDGEKPSDGQIPDGEKPSDGQMPDGEKTSDSQ
                     TPDVEKPSDGQMPDGEKPLDEQTPEEEKPLEEEIVIEEMSLKQDIDKILDMTLSQINK
                     IVYNFWEDEEDVKADEQSEINQVFTSEDSFISLWYDKKAKVKNSCLLKEIDGSDRPYH
                     DLRFDDITKTLTFDYVIKGLVGASSKDDKYVIEGEDGEQTAFCYNNHLRPPSSNGKSP
                     YLPAEDFNGQENQNEEAVKSILYAGSEFDGFGYKQQFNLGGEENELMTYSATQSAIWI
                     ILGQMDEQERLKQYQGSINLCDKLIERAKTEEERAEYQKKKEVAINIKAYLEALLKAG
                     REELKPNNTGKPSLSNGLTKINFEKNEDGTYETEAVALVGYSGVVKLKLPDGVTAYDG
                     DGNIIGTGEVEISTQQKFKLKSVGKPDAKANISAVSYDYIFPKAIQYYKAVLDLGQKD
                     HSSSLPSSKQNLLSYTIEKKNGQEVNFNIGLPTDDDDVVNPPVPPIDDDVVNPPVPPT
                     DDTNGHKPKPSPPIDDTVINPPVPPMDDTIINPPVPPTEDAVLNPPVPPMEDAVLNPP
                     VPPTEDTVLNPPVPSVSDTVEKTPELSRDDTIIKSPKTGDETQLMSYVFISVIAICGL
                     AYQCKIKRN"
     gene            11705..13465
                     /gene="prdR"
                     /locus_tag="KR257_000114"
     CDS             11705..13465
                     /gene="prdR"
                     /locus_tag="KR257_000114"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428097.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sigma-54 dependent transcriptional regulator
                     PrdR"
                     /protein_id="HBH0028846.1"
                     /translation="MFSIPEVKKVEEVMDTKFTTIDEDTRIEDAIKEMIKSNTKTLMV
                     IDSSDQLKGIISMTDIHNLYEMHKKYEGQPVKLIMKKDVIYVNEGLTLDECRDIMILK
                     NIGILPVLRDNKIIGVLKQEHIRDYLYMHLEDYGLTLKYIIGQIKEGICAINNEGVVI
                     LWNKFMEERYDIKSEDIVGRPMNEFLENTISEKVLNSKVGMSDLYFTDKKENMYALVH
                     ANPIFYKEEFIGVVCTEVDVTEAKILALELEKVNDTLKYLKNEVKNLSKGSFDKILGK
                     SYKLEKSKAIAKQVARTNSSIFIWGESGTGKEVFARAIHDYSERKGQFIPVNCSAIPN
                     ELFESEFFGYESGAFTGASKKGRIGIFELAKDGTVFLDEIADLPLSMQAKLLRVLQEK
                     EIRRVGGDTTIKINPRIISATNKDLSKMVKAEKFREDLYYRLNVVEIKIPPLRERKED
                     IGLLVHSFLEEICKQNNKPVLTISKDVIDIFQNYRWKGNIRELKNTIENIVVLSQNSK
                     IDVDDVPSYMMDSTNNSTEEEEYPLDLTKATQKIEIKNITKALKMSNGNKAKAAKILN
                     IPRTTLYYKIDQYKIDVSKI"
     gene            13894..15774
                     /gene="prdA"
                     /locus_tag="KR257_000115"
     CDS             13894..15774
                     /gene="prdA"
                     /locus_tag="KR257_000115"
                     /EC_number="1.21.4.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422104.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="D-proline reductase (dithiol) proprotein PrdA"
                     /protein_id="HBH0028847.1"
                     /translation="MSITLETAQAHANDPAVCCCRFEAGTIIAPENLEDPAIFADLED
                     SGLLTIPENGLTIGQVLGAKLKETLDALSPMTTDNVEGYKAGEAKEEVVEETVEEAAP
                     VSEAAVVPVSTGVAGETVKIHIGEGKNISLEIPLSVAGQAGVAAPVANVAAPVASAAA
                     EVAPKVEEKKLLRSLTKKHFKIDKVEFADETKIEGTTLYIRNAEEICKEANETQELVV
                     DMKLEIITPDKYETYSEAVLDIQPIATKEEGELGSGITRVIDGAVMVLTGTDEDGVQI
                     GEFGSSEGELNTTIMWGRPGAADKGEIFIKGQVTIKAGTNMERPGPLAAHRAFDYVTQ
                     EIREALKKVDNSLVVDEEVIEQYRREGKKKVVVIKEIMGQGAMHDNLILPVEPVGTLG
                     AQPNVDLGNMPVVLSPLEVLDGGIHALTCIGPASKEMSRHYWREPLVIRAMEDEEIDL
                     VGVVFVGSPQVNAEKFYVSKRLGMLVEAMEVDGAVVTTEGFGNNHIDFASHIEQIGMR
                     GIPVVGVSFSAVQGALVVGNKYMTHMVDNNKSKQGIENEILSNNTLAPEDAVRIMAML
                     KNAIEGVEVKAPERKWNPNVKLNNIEAIEKVTGEKIVLEENEQSLPMSKKRREIYEKD
                     EN"
     gene            15855..16139
                     /locus_tag="KR257_000116"
     CDS             15855..16139
                     /locus_tag="KR257_000116"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422102.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0028848.1"
                     /translation="MDRLKYISSETFYEGIIVDIKGGGVTIDLKGRLGQFKIPNRMLI
                     TDYELKIGQEVGFMLSYPEVLSPEPNQEYVENIRREKEKQAEMQSKQEEK"
     gene            16177..16902
                     /gene="prdB"
                     /locus_tag="KR257_000117"
     CDS             16177..16902
                     /gene="prdB"
                     /locus_tag="KR257_000117"
                     /EC_number="1.21.4.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011986824.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_except=(pos:16627..16629,aa:Sec)
                     /transl_table=11
                     /product="D-proline reductase (dithiol) protein PrdB"
                     /protein_id="HBH0028849.1"
                     /translation="MSLTTVQGLQSEIFVPITPPPVWTPVTKELKDMTIALATAAGVH
                     LKSDKRFNLAGDTTFRAIPNTATVDEMMVSHGGYDNGDVNKDINCMFPIDRLHELAAE
                     GFIKGVAPMHYAFMGGGGNQHVFTEETGPAIAAKLKEEGVDGVVMTAGUGTCHRTAVI
                     VQRAIEEAGIPTIIIAALPPVVRQNGTPRAVAPLVPMGANAGEPHNIEMQTHILRDTL
                     EQLVAIPSAGKIVPLPYEYKAHV"
     gene            16982..17740
                     /gene="prdD"
                     /locus_tag="KR257_000118"
     CDS             16982..17740
                     /gene="prdD"
                     /locus_tag="KR257_000118"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903671.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="proline reductase cluster protein PrdD"
                     /protein_id="HBH0028850.1"
                     /translation="MEEKIMRRLVIKPFHMNEVNFGSKTSIKKDVLTIDLSSIDEIKE
                     REELITDIKVDIIKPGDYDREINTIMDIIPISTKVLGRLGEGITHTLTGVYVMLTGAD
                     EDGNQMHEFGSSEGILKDQMVFGRYGTPSVEDYIIHVDVTLKGGLPFERTLPLAAFRA
                     CDDFIQEIRASLKMEDGRNATQVREYFDKIRPNAKKVVIVKQIAGQGAMYDNQLFSKE
                     PSGFEGGTSIIDMGNVPMIISPNEYRDGALRAMT"
     gene            17755..18222
                     /locus_tag="KR257_000119"
     CDS             17755..18222
                     /locus_tag="KR257_000119"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422094.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="proline reductase"
                     /protein_id="HBH0028851.1"
                     /translation="MGIGPSTKETSLHHFRDPLLDIVESDKDVDLLGVIVVGTPDGNE
                     NKTFVGQRTAAWLEAMRVDGAIVSSDGWGNSHVDYANTFEEIGKRDIPVVGVTFNGTQ
                     AKFVVSNQYMDTIVDMNKSKEGIETEVVGENNTNEIDAKKALAFLKLKMRKHG"
     gene            18240..18722
                     /locus_tag="KR257_000120"
                     /pseudo
     CDS             18240..18722
                     /locus_tag="KR257_000120"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428088.1"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="proline reductase"
     gene            18742..19749
                     /locus_tag="KR257_000121"
     CDS             18742..19749
                     /locus_tag="KR257_000121"
                     /EC_number="5.1.1.4"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422090.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="proline racemase"
                     /protein_id="HBH0028852.1"
                     /translation="MKFSRSIQAIDSHTAGEATRIVVGGIPNIKGNSMPEKKEYLEEN
                     LDYLRTAIMLEPRGHNDMFGSVMTQPCCPDADFGIIFMDGGGYLNMCGHGTIGAMTAA
                     IETGVVPAVEPVTHVVMEAPAGIIRGDVTVVDGKAKEVSFLNVPAFLYKEGVEVDLPG
                     VGTVKFDISFGGSFFAIIHASQLGLKIEPQNAGKLTELAMKLRDIINEKIEIQHPTLA
                     HIKTVDLVEIYDEPTHPEATYKNVVIFGQGQVDRSPCGTGTSAKLATLHAKGELKVGE
                     KFVYESILGTLFKGEIVEETKVADFNAVVPKITGSAYITGFNHFVIDEEDPLKHGFIL
                     K"
     gene            19869..20750
                     /locus_tag="KR257_000122"
     CDS             19869..20750
                     /locus_tag="KR257_000122"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422088.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TSUP family transporter"
                     /protein_id="HBH0028853.1"
                     /translation="MVAILKALYVVFAAIFAVVFGKDVAKANKEGKLEEQSTPKVAVT
                     GFITDFFDTLGIGSFAPTIAMSKALKLNIPDKKMPGTLNVAHTIPVVTEAFIFTSIIP
                     VDGVTLVSMVVAAAVGSYIGAGIIAKMDERKIQLVMGVTLALTAILMLLGHPWINVLP
                     GGGNELGLTGVKLVIGVIGNFILGALMTAGIGLYAPGMAMVYFLGMSAKVAFPIVMGS
                     CALLMPVASMKFIKEDAYTKKASVIIAICGLIGVFVAAYIVKTLPMDILKALVIVVIA
                     YTSATMIMAANKNKKTA"
     gene            21418..22053
                     /locus_tag="KR257_000123"
     CDS             21418..22053
                     /locus_tag="KR257_000123"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422086.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="single-stranded DNA-binding protein"
                     /protein_id="HBH0028854.1"
                     /translation="MIAVKDENNVVNLRGELDNKLEFSHEIFGEKFYNMKIKINRLSD
                     SFDILPMTVSERLLQDIDLDKQNLVNVVGQLRSYNKTLNNKNRLVLTVFVREIKSIDE
                     ENKDPNSIFLDGYVCKEPVYRKTPLGREITDLLVAINRPYNKSDYIPSIVWGRNAKFA
                     KNLKVGDRIQLWGRVQSREYEKKIDENNVVKKMAYEVSISKIKKLDENNNE"
     gene            22237..22806
                     /locus_tag="KR257_000124"
     CDS             22237..22806
                     /locus_tag="KR257_000124"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422084.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="methyltransferase domain-containing protein"
                     /protein_id="HBH0028855.1"
                     /translation="MKSILCQINKQPVKAKYTSDELECFLDTIEYNVGDKILLVGHIG
                     NLGKRLRGLGTSVTILENSNYEDVCYSLVYNENCNVVKGKLEFLPFDDNQFNKIIIVD
                     QFNVITDCEKASSEIQRVLKGNGEVILEDLNLKNLKVKLNYLKHKFCGSVAKIHYPHE
                     VFNIFSRLNFDGMIKESNKLKYIYVGKRR"
     gene            22884..23021
                     /locus_tag="KR257_000125"
     CDS             22884..23021
                     /locus_tag="KR257_000125"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422082.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0028856.1"
                     /translation="MEINYELIIIVMLFVILMSIQFTLNKIYLILKEIRQILMLKKNK
                     E"
     gene            23018..24793
                     /locus_tag="KR257_000126"
     CDS             23018..24793
                     /locus_tag="KR257_000126"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428083.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sigma 54-interacting transcriptional regulator"
                     /protein_id="HBH0028857.1"
                     /translation="MMIMIGLEYIKSDIQNIAEAIVSVLNIDVTIVNKELFRIAGTGV
                     YIDKIGEKVDKYTAFKKSLTEQITILIDDPKSSDICRECYKSGACVEFAEVCCPIICD
                     GVSHGVIGLIAFTKEQAQIIENNKSGLINFLGKMADLISNKLKAQIKTYELELEKKKL
                     ETLLNNMDKAVVSIDVDGKIDKYNSKFKELFNIKDSITGKNIFVELDFIKKPSINNFK
                     KDKSCSFFYKRYGYDSKGIYNINKIVLKNELKGYVIDFIDKRDAIKNYNKMNKDYRIK
                     LENIIGESVAIRNSKKEALIASKSTSTVLITGESGTGKELFARAIHNHSNRVDNPFIA
                     VNCAAIPDNLLESELFGYEEGAFTGAKKGGKLGMFEVAHKGSIFLDEIGDMSLHLQSK
                     LLRVLQEKELNKIGSKSNVSIDVRIIAATNKDLEKMVQNGTFREDLYYRLNVIPIKLP
                     SLRERKEDIPLIIKHMVKEYSKKLDKNVIDIDSRVVDAMMEYKWPGNIRELQNIIEYS
                     VNMSSSSIITMNVIPQKIKNTSVEELEVKSDRIIPLDELEKIEIIKALNKYKDYKKDK
                     ELTAKALGISRATLYRKIEKYNIIS"
     gene            25218..26525
                     /locus_tag="KR257_000127"
     CDS             25218..26525
                     /locus_tag="KR257_000127"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454042.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="serine dehydratase subunit alpha family protein"
                     /protein_id="HBH0028858.1"
                     /translation="MRDIRKELVEMLKAEVKPAVGCTEPVALALACAKAKELLGEEIV
                     ENRMLVSPSIYKNGMCVGIPGTERLGLKIAAALGIVGGHSENGLSVLETLTKEEVKIA
                     EDYMDNTPLSITPADTREKVFIEVVLKGKNHIAKVRIRTKHDNFTFLEKDGEVLLDNE
                     PKVSASNDAAEKAESLMDTVTIQELIKNVEGIDFKDIEFLLDGVKMNEEMAEYGLKQK
                     TGIGVGYGIKKSIEEGLLGNDVINYAMMLTAGASDARMAGVKMPVMSSNGSGNHGLTA
                     ILPIVAYNKKFPQSDERLAKALAISHLVTGYIKNYTGRLSAVCGCGVAASTGATAGIS
                     WLMNGTEKQIEGAIENMIADLSGMICDGAKAGCALKLSSAASAAIQSAIIAKQDCFVP
                     PLNGIVGSSVEQSIQNLGRVSDKGMSITDEIILNVMNDMNKVD"
     gene            26853..27392
                     /gene="hpt"
                     /locus_tag="KR257_000128"
     CDS             26853..27392
                     /gene="hpt"
                     /locus_tag="KR257_000128"
                     /EC_number="2.4.2.8"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422077.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypoxanthine phosphoribosyltransferase"
                     /protein_id="HBH0028859.1"
                     /translation="MDIETKKWEVLYSEEKIKDKLRELGAIIEKDYKDKNLMVVSLLK
                     GSFIFCADLVRNINLPLRVNFMTTSSYGNNEESTGKVKVVSDVTTDIAGYDVLVVDDI
                     TDSALTMDFVLKHLKAKNPASLKCCVLLDKPSRRKVDLVPDYCGFEIEDKFVVGYGFD
                     FGDYYRNVPYIFNVTDEDR"
     gene            27770..29491
                     /gene="bclA2"
                     /locus_tag="KR257_000129"
     CDS             27770..29491
                     /gene="bclA2"
                     /locus_tag="KR257_000129"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861885.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="collagen-like exosporium glycoprotein BclA2"
                     /protein_id="HBH0028860.1"
                     /translation="MSDISGPSLYQDVGPTGPTGATGPTGPTGPRGVTGATGANGITG
                     PTGNTGATGANGITGPTGNMGATGPNGTTGSTGPTGNTGATGANGITGPTGNTGATGA
                     NGITGPTGNKGATGANGITGSTGPTGNTGATGANGITGPTGNTGATGATGPTGLTGAT
                     GATGANGITGPTGNTGATGANGVTGATGPTGNTGATGPTGSIGATGATGTTGATGPIG
                     ATGATGADGEVGPTGAVGATGPDGLVGPTGPTGPTGATGANGLVGPTGPTGATGANGL
                     VGPTGPTGATGANGLVGPTGATGATGVAGAIGPTGAVGATGPTGADGAVGPTGATGAT
                     GANGATGPTGAVGATGANGVAGPIGPTGPTGENGVAGATGATGATGANGATGPTGAVG
                     ATGANGVAGAIGPTGPTGANGATGATGATGATGANGATGPTGATGATGVLAANNAQFT
                     VSSSSLVNNTLVTFNSSFINGTNITFPTSSTINLAVGGIYNVSFGIRATLSLAGFMSI
                     TTNFNGVTQNNFIAKAVNTLTSSDVSVSLSFLVDARAAAVTLSFTFGSGTTGTSAAGY
                     VSVYRIQ"
     gene            complement(30074..30829)
                     /locus_tag="KR257_000130"
     CDS             complement(30074..30829)
                     /locus_tag="KR257_000130"
                     /EC_number="1.17.1.8"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422070.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="4-hydroxy-tetrahydrodipicolinate reductase"
                     /protein_id="HBH0028861.1"
                     /translation="MLKVIISGYNGTMGRVLAECVKKDNELELVCGVARSADEKGHHS
                     DTKLYKTMTDVTEKTDVIIDFSHHDTLEPILSYALKNNTPVVLATTGYDENDLNKIEE
                     ASKNIPILLSSNTSLGVNILIKLVKDASKMLEGFDIEIIEKHHNRKEDAPSGTATMIA
                     NAIREVLPESENTHGRYGRDCKRKPNEIGIHSIRGGNIISDHDVVFAGDNEVLTLSHH
                     SQSDEVFANGSIVAAKFLIGKQSGLYKMSDILG"
     gene            31269..32258
                     /locus_tag="KR257_000131"
     CDS             31269..32258
                     /locus_tag="KR257_000131"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018112569.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SPFH domain-containing protein"
                     /protein_id="HBH0028862.1"
                     /translation="MLKEEKTYQEKDAKVFNGVAALIMILLFLVVSIGIMVFGIVKLD
                     SGFTGIGSLMLILGLVFIVVDFILFFGLKMINPKEAIVLVLFGNYYGTIKKEGYYWVN
                     PFCSAINPAVSRINVSKSSSDEKVDISTNSRGKKVSLKTMTLNNEKQKVNDLLGNPII
                     IGVVVIWKVIDATKAVFNVDNYNTFLSIQCDSTIRNVSRLYPYDVSEDGDEKSLRGSS
                     QEIADRLKDELQSRVDIAGIEVCEVRITHLSYAPEIAAAMLQRQQAEAIIAARKKIVE
                     GAVSMVEMALTNLSENNVVTLDEERKAAMVSNLLVVLCGNKDAQPVVNSSSIY"
     gene            complement(32710..33426)
                     /gene="dapD"
                     /locus_tag="KR257_000132"
     CDS             complement(32710..33426)
                     /gene="dapD"
                     /locus_tag="KR257_000132"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428057.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="2,3,4,5-tetrahydropyridine-2,6-dicarboxylate
                     N-acetyltransferase"
                     /protein_id="HBH0028863.1"
                     /translation="MVNLNDAYEIARYIKEVKKKTPVKVYVNTNSLHFQSTDKFKVFG
                     SNGSYIFVGDYEDIMEVLDKHGNDITDTHVEYDRRNSAIPLKNTLSEHARIEPGAIIR
                     DMVTIEKNAVVMMGAVINIGAVIGEGSMVDMNAVIGARGTLGKNVHLGAGAVVAGVLE
                     PPSATPVIVEDDVLIGANAVILEGVRIGKGAVVAAGAVVTTDVEAGAVVAGSPAKVIK
                     MKDEKTADKTKLMEDLRNLD"
     gene            complement(33650..34399)
                     /locus_tag="KR257_000133"
     CDS             complement(33650..34399)
                     /locus_tag="KR257_000133"
                     /EC_number="1.17.1.8"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891682.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="4-hydroxy-tetrahydrodipicolinate reductase"
                     /protein_id="HBH0028864.1"
                     /translation="MLKVIATGYDGKMGKILADTIREDNELELVCVAARGLDSYEGDL
                     KIYEDMSTIVEEADVVIDFSHHSNLDNILSYVLKTKTPLVIATTGYNDDEMNKIREAA
                     KVIPVFQSYNMSLGVNVLVKLVKDAAKLLEGFDIEIIEKHHNRKVDAPSGTAVMIANA
                     IKEVLPNVENNYGRYGRSAKRQPNEVGIHAIRGGNIVGEHDALFAGDNEVLTISHQAQ
                     SRGIFASGSIAAAKYLVKQKPGFYNMDSMLG"
     gene            complement(34466..35353)
                     /locus_tag="KR257_000134"
     CDS             complement(34466..35353)
                     /locus_tag="KR257_000134"
                     /EC_number="4.3.3.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422063.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="4-hydroxy-tetrahydrodipicolinate synthase"
                     /protein_id="HBH0028865.1"
                     /translation="MIFKGSAVALVTPFTKDNKVDFDKLGELVEYQIANGTDAIVSCG
                     TTGEANTMTDEEQLATIKYVVEKVNKRVPVIAGSGSNDTMHSVNLSQEAEKLGVDALL
                     IITPYYNKANKAGLKRHFETIANSVKLPIILYNVPGRTCVNISPSLIVELAKIDNIVA
                     VKEASGDLGQVAEIASLVPDDFAIYSGNDDTILPLLSLGGQGVISVLANVCPQETHDL
                     VAKFFEGDIEGSRKLQLGMDALIAALFIEVNPIPVKTAMNLLGFNVGDLRLPLAEMDP
                     ANLEVLKKELVNFGLKVNA"
     gene            complement(35470..36471)
                     /locus_tag="KR257_000135"
     CDS             complement(35470..36471)
                     /locus_tag="KR257_000135"
                     /EC_number="1.2.1.11"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438805.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aspartate-semialdehyde dehydrogenase"
                     /protein_id="HBH0028866.1"
                     /translation="MKKVNVAIIGATGMVGRTFLKVLEERNFPIENLFLFSSSKSAGS
                     KVMFCGKEYIVEELKETSFTDRGIQIALFSAGGSISEKYAPIAASNGILVVDNSSQWR
                     MNPDVPLVVPEVNPEAIKNHKGIIANPNCSTIQAMVPLKALDDKYKIKRVVYSTYQAV
                     SGSGVKGVEDLEKGMNGNPTGFYPHQISYNCLPHIDSFTENGYTKEEMKMVNETMKIL
                     DNYDLKITATTVRVPVKNGHSESINVEFNNPFELDDLVKTLEEAPGVVVVDNPAKNEY
                     PTAVEFDDRDEVFVGRIRRDFSVDNGVNLWVVADNIRKGAATNAIQIAEMALSYDLV"
     gene            complement(36896..37777)
                     /locus_tag="KR257_000136"
     CDS             complement(36896..37777)
                     /locus_tag="KR257_000136"
                     /EC_number="4.3.3.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422060.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="4-hydroxy-tetrahydrodipicolinate synthase"
                     /protein_id="HBH0028867.1"
                     /translation="MLFKGSAVALVTPFTEDNNVNFEKLGELIEYHIENGTDALVVCG
                     TTGEATTMSESEIFAVIKYTVEKVNKRIPVIAGTGSNNTMLSVHMSQEAEKLGVDGLL
                     IITPYYNKTNEKGLKLHFETIANSVKLPIILYNVPGRTKVNIKPSVVAELAKIDNIVA
                     VKEASGDLAQVAEIAKLVPKDFAIYSGNDDTILPLLSLGGSGIISVLANICPKETHDL
                     VTKFFEGDIEGSKKLQLDMDALIAALFIEVNPVPVKTAMNILGFNVGDLRLPLAEMEE
                     TNLNVLKQELTNFGFKF"
     gene            38100..39293
                     /locus_tag="KR257_000137"
     CDS             38100..39293
                     /locus_tag="KR257_000137"
                     /EC_number="4.3.1.17"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422058.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="L-serine ammonia-lyase"
                     /protein_id="HBH0028868.1"
                     /translation="MDTLKELFKIGSGPSSSHTMGPQRAAERFKNENPDAESFRAILY
                     GSLAATGKGHLTDYIIEKTIAPKKVEIVWEEDIIKDFHPNGMKFEALDKDKNVTAEWT
                     VYSVGGGTIAEEGQRNSKSNSIYHLDTMDEIVKWCKENNKTLVDFVLECEPKDIKDYI
                     KTIKDAMRKSIDDGLSTDEIIPGKLLLKRRASTFYNAYKKDKSFSTLVYAYALAASEQ
                     NASGNIIVTAPTCGSAGVIPGIFFAMQDFYNYDDEKIIEALLVAGIIGNIIKTNASIS
                     GAEVGCQGEVGAACSMAAAAVAYLKGGTIDHIEYAAEIALEHHLGMTCDPVYGYVQIP
                     CIERNAMAAQRAYDAANYALLTDGSHSVSLDQVVETMKETGIDMMDKYKETAKGGLAK
                     HFFSC"
     gene            39499..40617
                     /locus_tag="KR257_000138"
     CDS             39499..40617
                     /locus_tag="KR257_000138"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438795.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="N-acetyldiaminopimelate deacetylase"
                     /protein_id="HBH0028869.1"
                     /translation="MREASYLQEQLYKHRKSLNPIAEIGRKEYKTSKYIRDYLDKLGI
                     EYEVYLETGIVGVIEGKRPKKDIAFRADIDGLHSEEGVKHLCGHDGHATILLGLIEYL
                     NDNKEDLNDNIVFIFQPAEEGPGGAKALIDEGVLRKYNIDEIYGLHIYPELPEGYVGT
                     REGYFMAQIGDIDIEIVSKSGHGAMPQNGIDGIVIASNFVSSLQTIVSRNISPIDNAV
                     LTIGRIEGGARRNIIAENIKMEGTMRCFSPEVYEKMKLRVRELARGFELAYNCKVNIN
                     IIDDYIAVKNDKDLYQEFVEAIGSDTVVELEPLMISEDFSYYQKEVPGLFFMLGSRNE
                     EKGFVNGLHNINFNFDEKICVNALNVYSKLLKYKEAID"
     gene            40748..40993
                     /locus_tag="KR257_000139"
     CDS             40748..40993
                     /locus_tag="KR257_000139"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009906336.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="small, acid-soluble spore protein, alpha/beta
                     type"
                     /protein_id="HBH0028870.1"
                     /translation="MKEKVQREKKITNGKNTKILTNDDIMKYEIASELGLMDKVGERG
                     WAGLTAKEAGRIGGMLTSRKKRLKKIVEEQNKKDESI"
     gene            40980..41726
                     /locus_tag="KR257_000140"
     CDS             40980..41726
                     /locus_tag="KR257_000140"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728838.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="methyltransferase domain-containing protein"
                     /protein_id="HBH0028871.1"
                     /translation="MSQYSDFAFVYDELMNEVDYNGWVKYIEDIIDSEGVKVKNILEL
                     ACGTGNLTIPLTKKNYDIAGIDISDEMLSVAREKSEKEGVELVLLQQDISELDFEISD
                     LDCVLCACDGFNYITYDDDLENVFSKTYELLKKDGIFIFDISSFYKLANILGNNMYGE
                     NREDIAYMWQNYFDEEENLIEMELTFFIKDECGKFERFEEIHQQRAYTEDEIVDMLEK
                     SGFKDIKYYGDFTFDKPSEESQRIFFVCKK"
     gene            42011..42886
                     /gene="hslO"
                     /locus_tag="KR257_000141"
     CDS             42011..42886
                     /gene="hslO"
                     /locus_tag="KR257_000141"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903657.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Hsp33 family molecular chaperone HslO"
                     /protein_id="HBH0028872.1"
                     /translation="MRDYVLRATSGNGQVRAFVATTRNTVEEARRLHETTKVATAALG
                     RTLTATSIMGLMMKNDSDKLTVIIKGGGPIGTIIATSDSKGMVKGYVGNPQVEVEDYP
                     NGKLNVAAAVGTEGVVKVIKDLGLREPYNGTYPLVSGEIAEDFTYYFAVSEQTPSVVA
                     LGVLTKEDEVEFAGGFIVQLMPDAEEETIAKLEENVAKLPSITNMLKEGKSPEDILNI
                     VLDGLEPKILDTCEVGFMCECSKERVKTALVAIGKKSLAQIIEEDKKAEVGCQFCNKK
                     YMYSEEELLEILKEM"
     gene            43277..44077
                     /locus_tag="KR257_000142"
     CDS             43277..44077
                     /locus_tag="KR257_000142"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903655.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PIG-L family deacetylase"
                     /protein_id="HBH0028873.1"
                     /translation="MESKTKYIGISILILLMIFLIAKNFNGKLEIPIPESNSRKFKSA
                     AVFYPQHQDDEVLWGGSAIVDAIKQCGVDNVYVVLVSDGSGVNVFKANTKFRNLTRKQ
                     KEELRNNEFKSALRELGVKPQNVIILADIDKKEGTHYELMEKTILDFEHKFKGNVTHI
                     AHHYKYDDHIMHRKNGEVLKKLKREGKIKDDLYFVKPKYVKYIPRNERAIYKAMDFDD
                     YNKVKSACYEYKVVNSKRKMYGIGYISAHSYFEHLLNDPELTSVLSED"
     gene            44604..46844
                     /locus_tag="KR257_000143"
     CDS             44604..46844
                     /locus_tag="KR257_000143"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728840.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="excinuclease ABC subunit UvrA"
                     /protein_id="HBH0028874.1"
                     /translation="MNNEFIILKGCKENNLNNISLKIPKRKITIFTGVSGSGKSSIVF
                     ETIAKESQRQLNERFSTFVRSFLPKYGEVKADCIENLSTPIIIDQSRLGGNSRSTLGT
                     ITDVNSFLRALYSRFGSEYIGNANMFSFNNIDGMCPHCHGLGKKLVPNMNQILDMNKS
                     LNEGAILLSGFGVGSWHWNIFAESGFFDINKRICDYSEVELEKFLHGKAEKIKIENAG
                     QTNMTYEGLMVKFNRLYLSREGEISEATKKKLSKLLIEDRCPICDGRRLNERVYRSLI
                     NGYNIADLTSMQIDELAEVIKSIDEPEAQPLIKGIIEKLNSIIDIGLGYLTLDRETSS
                     LSGGESQRIKMVKYLNSNLVDLMYIFDEPSVGLHPKDVYKLNNLLKKLRDKGNTIIVV
                     EHDPDVIKIADHIVDVGPKAGKYGGEVVYEGSYENLLTSGTLTGNALSKFLPIKESVR
                     EHSGYLEVKNCNKNNLKNVSIKIPKGVLTLVTGVAGAGKSTLIKDEFLKQNPSAVLID
                     QSPVSANSRSSLATYSGIMNNIRSIFSKTNGVNASLFSSNSEGACDNCKGSGIVEMNL
                     AFMESIKSTCNVCEGKKFKKEVLEYRFQGKNIIEVLEMSVLEAIEFFNLKQIKTKLQC
                     IEKMGIGYLTLGQTLDTLSGGECQRLKLASELNKESSVYILDEPTTGLHMADIENFIS
                     IIEEIVDNGNTVIIIEHNIDVIKRADWIIELGPEGGTKGGRVIFEGIPKQLCNNKISL
                     TAKYIV"
     gene            47258..48793
                     /locus_tag="KR257_000144"
     CDS             47258..48793
                     /locus_tag="KR257_000144"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422046.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease subunit"
                     /protein_id="HBH0028875.1"
                     /translation="MINDILTLLSERSDFFIKLSIEHLMISIISIIIAIVLGGIIGII
                     VSEFHNSSKPILGTINFLYTIPSISMLGFLIPFSGIGNTTAVIALTIYALLPMVRNTY
                     TGITNVDKNILEAARGMGSTDFQILYKIKLPLALPVIMSGIRNMVIMTIALAGIASFI
                     GAGGLGVAIYRGITTNNTIMTITGSILIALLALIFDFILGLVEKFFQRKRKKKNRKKV
                     FAILGSLILIATIFTSYLFNPSKTQTIHIATKPMTEQYILGEMLDILIEKNTGLNVEI
                     TQGVGGGTSNIQPAMENGEFDIYPEYTGTGWNMVLKKNELYTESMFSKLQSEYKTKLK
                     MQWTGMYGFSNSYALAVRKEVADKYNLKNITDLKDVSSKLTFGAEYDFYEREDGYTPL
                     CNTYGLNFKDTVDLDIGLKYQAINEGKIDVMPIFTTDGQYSVSDVVVLKDDKNFYPSY
                     QCGNVVRLEVLEENPELSKVFKMVGDILTDKEMAKMNYDVENNNLEPREVAREFLNKK
                     GLL"
     gene            48809..49570
                     /locus_tag="KR257_000145"
     CDS             48809..49570
                     /locus_tag="KR257_000145"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438780.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBH0028876.1"
                     /translation="MTPIIQFKNIKKQYNDKTIIDNLNLDIEKGEFLTVIGSSGSGKT
                     TLLKMINGLILPDGGNILINQTDIKNEDLIKLRRRIGYCVQGSVLFPHMTVEENISYV
                     PNLLSKKNKLEVKSAVNKWMEIVGLPNDMKVRYPSELSGGQQQRVGIARALASSPEIL
                     LMDEPFGAVDEITRKQLQKEIKEIHKKTGVTIIFITHDIYEALILGTKTLVLNHGVVQ
                     QYDTPENILNTPANQFVDQLLNIRKSIIDDDNLKE"
     gene            49908..50777
                     /locus_tag="KR257_000146"
     CDS             49908..50777
                     /locus_tag="KR257_000146"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438778.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AraC family transcriptional regulator"
                     /protein_id="HBH0028877.1"
                     /translation="MDNNLITIEKTLDYIEKHLLDEMLDLNVISKEIGYSKYHLHRMF
                     TSVVGFSVHNYIQRRRLTEAARMLIFTEKPIIEIALISGYDTQRSFSRGFKKMFKRSP
                     NFFRRHQDFLPLQLKFDIHNRKKLRGDMVLDVKKVNCADINIVGYSGKVRKGFHIIGK
                     CWRDLHKNKEMIENKVDLGFLIGVSDYSNFKEIENTPTFTYIAGAQVATFGKLPNGME
                     KFVLPKSNYIVFTFIGKNEDSMQNVVEYIYQEWFPNSSCQFNENNLYDFVKYGEKTDE
                     NGLSEIQFWVPII"
     gene            51106..51357
                     /locus_tag="KR257_000147"
     CDS             51106..51357
                     /locus_tag="KR257_000147"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422043.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3781 domain-containing protein"
                     /protein_id="HBH0028878.1"
                     /translation="MNVENELLKNLDRLHTTELGVVRIKKNLSLETNDVVNWCKTKIE
                     SPNAIINRKGKNWYISVYDCIITVNAHSYTIITAHKEKK"
     gene            51469..52248
                     /locus_tag="KR257_000148"
     CDS             51469..52248
                     /locus_tag="KR257_000148"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891659.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="HBH0028879.1"
                     /translation="MNDTVKEKLAESLTSDTTDILPYLPYLLQDFWELGSSPEQMLQL
                     FRKHIPFNEDTKVLDLACGKGAVSVKLAKELNIHIKGIDLIPEFIDYARRKAIEYKVD
                     ALCDFEMNDANSSVKIEHDYDCVIFGAVGDILGNYKETISKLLPTIKSKGFILIDDAY
                     VVDKSTNEQLNFERVYPTYNEWCILFKELGLKLIECIPCLELENDVEEEMNWIITRAN
                     ELIKKYPSQKDMFEQYVISQKNEYTDLQQDLVGATWILQKE"
     gene            complement(52383..53033)
                     /locus_tag="KR257_000149"
     CDS             complement(52383..53033)
                     /locus_tag="KR257_000149"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438773.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0028880.1"
                     /translation="MNIVMINGSPKVNKNNSQYFLSELKQLIQNDNKVFTFKVDNTSK
                     YPDALNAILNCDRLIIASPLYVDGIPSHLLHFLEKCEKFLKTQNKKPIPVYAIVNCGF
                     NEGEHNHLAIQMIEHWCKKINFTWVQGIGIGAGEMFGSLESVPLGKGPKKDLGIALKE
                     LSKNILSDNIHIDDSNKSTIFISPNFPRFLYKLMGNHQWNTQAKSNGLTKSDILKK"
     gene            complement(53030..53533)
                     /locus_tag="KR257_000150"
     CDS             complement(53030..53533)
                     /locus_tag="KR257_000150"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861880.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flavodoxin family protein"
                     /protein_id="HBH0028881.1"
                     /translation="MRLLIHDLTDKELEKLLPKLDDNIKILPNTKEIHKCIGCFGCWI
                     KTPSECVVKDYYSNMGKLINDSDGIIIISRCCYGGFSPFVKNVLDKSINYILPYFVIK
                     DNMMRHKSRYDKQINLKAIFYGDCITEAEKETATKLVNGNAINFNIKEHSVCFYENIQ
                     DIRGESI"
     gene            complement(53582..54097)
                     /locus_tag="KR257_000151"
     CDS             complement(53582..54097)
                     /locus_tag="KR257_000151"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898339.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PadR family transcriptional regulator"
                     /protein_id="HBH0028882.1"
                     /translation="MLEYIILGFLMEKELSGYDLKQIMSESTSYFFDASFGSIYPALK
                     RLETKGYIHYHEVIDGNKLKKLYSITNTGKEVFLEWLKKPINFSKTKQDHLVNIFFYK
                     YLPKEIIETNLKMLITEVELLLNKLSKQKNDAEENHCVDQYTYMYATMIYGVDYYNFV
                     INWCKDLLKNL"
     gene            54377..54901
                     /locus_tag="KR257_000152"
     CDS             54377..54901
                     /locus_tag="KR257_000152"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422037.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MarR family transcriptional regulator"
                     /protein_id="HBH0028883.1"
                     /translation="MHEQIDCCERKKRTIDIKGENMRELLKWVSIINRYNTNYIDRKL
                     ADIGINNSQYFYVLHICNNPGITQDTIFEKILVNPSNITRALANLEKEGFITREPGVK
                     DKRTWHLYPTEKSLGCYDEILKITNGYVEELLSSFEKEEQELFMSMLKKVAFLAIDMN
                     EEAKLEAKENGRKI"
     gene            54885..56288
                     /locus_tag="KR257_000153"
     CDS             54885..56288
                     /locus_tag="KR257_000153"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438762.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MATE family efflux transporter"
                     /protein_id="HBH0028884.1"
                     /translation="MEEKYKEPLEYEKVSKLLTKYAIPSIIAMLVSALYNIVDQIFIG
                     QGVGVLGNAATNVTFPLTTICTAIALLLGIGGASKCSLELGAKNSEKATKAAGNSICL
                     MAVFGISLFIVVSIFLTPLLKFFGSTSEILPYAHTYTKITSIGLPFLIMSTGMSKLIL
                     ADGRPKASMFCMLIGAVINTILNPLFIFVFNMGIAGSALATVIGQLISFGISVHYIKN
                     FQHIKLHKKSFKLDSIIYKHIFALGSSSCFNQLAMTVTQIVMNNTLAYYGARSVYGSE
                     IPLACVGIIIKVNMIFISIIIGISQGMQPIIGYNYGAEKYNRVKEAYKFAVGSATIIS
                     VIAFLCFQLFPRQITSIFGNGNETYFIFAEHYFRTFLFLTFINGVQIVSSTFFTSIGK
                     SVLGLFTSLTRQILFLIPLIVILPMFMGIDGVMFAGPIADAAAAMVCIYFAVHEMKSL
                     TIKQNNLMSNHNKIAEV"
     gene            complement(56852..57163)
                     /locus_tag="KR257_000154"
     CDS             complement(56852..57163)
                     /locus_tag="KR257_000154"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422032.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0028885.1"
                     /translation="MKKIIKSFTFWFFLIALFEIYMHQIGQDSKSIVLIGLNPILSII
                     SRVDSFFVFMDSGMQIPCRTITGSISIYWYIASILSFLIYGIILDLIRIVISKIGNKT
                     K"
     gene            complement(57219..57812)
                     /locus_tag="KR257_000155"
     CDS             complement(57219..57812)
                     /locus_tag="KR257_000155"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428032.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nitroreductase family protein"
                     /protein_id="HBH0028886.1"
                     /translation="MISDSISKRRSIRKYKNQSISHETIEKIIEAGINAPSSKNRQPW
                     RFVVITEKEKESMLKAMSKGIQNEINDNGLLPGSRQHIAGANYTVEIMKQAPVTIFIL
                     NILGKSPLEKLSPEERFYEMANMQSIGAAIQNMSLTAVELGLGSLWICDVYFAYRELC
                     EWLNTDSQLVAAISLGYPDEEPSRRPRLQLSDVTEWR"
     gene            58663..59313
                     /locus_tag="KR257_000156"
     CDS             58663..59313
                     /locus_tag="KR257_000156"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422028.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="membrane protein insertase YidC"
                     /protein_id="HBH0028887.1"
                     /translation="MDFISSILQGLLSILFNFTGDFGISIVLITLIVKLVLMPLSLKQ
                     RFSVKKQQELAEKMEYIKEKYKNDTKELEKQIQVSSVESMKSMLGCLIVLVQMPVVYA
                     LYHVCLDMTKEFTTIIIPWIANLGTFDNLFILPCIYTLIMLASNLVNYIPYLKINSQV
                     KFNKQMAVVTTITSLILTVRTPVAIGLYFITSAIYSLIEDICFRIYFNRKNRIVTK"
     gene            59516..60187
                     /locus_tag="KR257_000157"
     CDS             59516..60187
                     /locus_tag="KR257_000157"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422026.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HBH0028888.1"
                     /translation="MAKILVVEDEKRMQNIIVEYMQKGGYTCITADDGVEALTILKSN
                     NIDLMILDIMMPYLDGFSVCRVSREMTNIPIIILTAKGEEEDKLKGYEYGADDYITKP
                     FSPKVLLAKVNALLRRYTTDIPKNSLSLGKIFIMVASRQVYVEDKLIDLTYKEFELLR
                     LFMENPNQVFSREKLLNCIWGYDFEGNTRTVDTHIKTLRKKLGSEGHHIVTLIRSGYK
                     FEVKE"
     gene            60184..61314
                     /locus_tag="KR257_000158"
     CDS             60184..61314
                     /locus_tag="KR257_000158"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861876.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HAMP domain-containing histidine kinase"
                     /protein_id="HBH0028889.1"
                     /translation="MNSLRKIIEKLKNVDISNWIKQNFGLYSVRKKVFLLSKLSGALI
                     ILFYLVVEEFSINSKFEFWIWFIILVIFIMSIDFLLGKFISEPITSINKSAKSMSQLD
                     FSNPCTVNTNDEFGELSRSLNTMSTNLQQALSDLESANIQLEKDVNKERMLLEQRKEL
                     VDTISHEMKTPLGIIRAYTEGLIDEVDEEKKKNYMNVIIEETDRMNNMIVSLLDLSAL
                     EAGVSKLNPERFDFIEFVETVAGRLLIDIPDANFYFTYDLPEYEVFVVADKMRMEQVV
                     ENLVINAKKHVVYNGNLDLSITCENGLLLFEIYNDGRFIEQDEISKIWSKFYRSVQSQ
                     RTGGSGLGLAIVSQILTMQGLEYGVNNRDRGVEFYFMIPIDE"
     gene            61745..62590
                     /locus_tag="KR257_000159"
     CDS             61745..62590
                     /locus_tag="KR257_000159"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861875.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBH0028890.1"
                     /translation="MIKVRELKFSYGKDKQILHGLNFEVKEGEIFGFLGPNGSGKSTT
                     QKILNGVLKGYNGHVSIFGKEVKAYTESLYQKIGVLFEFPYLYTNLSAIDNLEYFSSF
                     YPKNQRRDIYELLDLLEFKKEFINKPVSSYSKGMKQRISMARALVSNPKLLFLDEPTS
                     GLDPSGAVLFRKIIEEERKKGTTIFLTTHNMLDADLMCNNVAFIADGKIMVIDKPKNL
                     KMKNSNNKVEVEFVYNGNRDIEIVDIQELESGITFKYDEILSVHSKEPTLEEVFIKYT
                     GRMLV"
     gene            62590..63618
                     /locus_tag="KR257_000160"
     CDS             62590..63618
                     /locus_tag="KR257_000160"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434295.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBH0028891.1"
                     /translation="MYSKFFTLVKKDFWMMIYGKFFVLTLGSLILYSCYINFGYVKFM
                     DEDSYHNNVYLYNPENISMSASPLINQVSSIGELKAKLDEDTSAVCIDMSSSKPKVIL
                     HESIKGVDNYRADYALSLLSSEKDHNSKISDNNAIIQINDKDTSEIKQRKDMTCEILF
                     FEIVAIGFLGIASLLFKEKQMGVMRITGILPVKRSLFILSKIFAFFICDLCFTVLLVV
                     FNIGFLEGIKILPQVLVQASILSIIMSLIGIGCSMLLRDFKQFSLIYLVVAVFITTPI
                     FLSANTSFEIDWIKYHPFYHVYSQLKNAFFMNFSKELVYFVVCSLTIIVLFLLVKYIF
                     NKELVREG"
     gene            63621..64634
                     /locus_tag="KR257_000161"
     CDS             63621..64634
                     /locus_tag="KR257_000161"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861874.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBH0028892.1"
                     /translation="MIGLRYQLKSIKKDKMCIISFFLPVVMAILINFMGTIDISSLGE
                     IRFGIVKDTLPVQTEQWLKKYGMVSVYDTKMHLIREIKDIKTDTIGVVRDGKGIKTVF
                     YGNEINAIKNVGKTLPEMFRLKGDLKDVEVTILPKDSILKEFQNVFIAMILITAMFMG
                     CTFNAMNIISEKEDGISFINEVLPQSRSQYIIQKVFLGLLCGCLSSMITVFICLDISI
                     LDMIMMLLLVVFSAFISSLIGLFIGKLSEGLMVGIVYIKIVMILFIGTPLLIYLLGVN
                     TSGIGNLCYIMPSVATFNGIMEIINGNVIIIKDIVILAVHCVVWFMIYIILDKKRKLS
                     FSR"
     gene            complement(65151..66401)
                     /gene="cme"
                     /locus_tag="KR257_000162"
     CDS             complement(65151..66401)
                     /gene="cme"
                     /locus_tag="KR257_000162"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434293.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="multidrug efflux MFS transporter Cme"
                     /protein_id="HBH0028893.1"
                     /translation="MENKNTNSTWKKKVILFLASQYISLFGSSLVQMAMIWYVTLQTS
                     SGVWVTVLTVCSFIPQMIISFFAGVWADYYNRKVLIIVSDSTIAISTLVLILFMMSSN
                     GTTSELIAISVISVIRSLGSGVQTPAVNAMIPQLVPEEHLMRFNGINSSLQSIVQFIV
                     PIVAAAILGFGNKINQVLLIDVFTAIIAIVLLIFIKIPKHDIPKQTEKVSFFADMVSG
                     IKYCFSDKFIRKVLFTYGAFMLLCVPSGFLIGLLIERTFGKGYIYLSIIEMIGFLGMV
                     LGGLIIGVFGGFKNRNKTFFLAILSYAIFSIILGLVTQAWQFFIFMFFTNFSIPIIQA
                     SAMTMLQEHVAPQMLGRVLSLPIIIYTGFIPLGMMIFGPMADVISINNLIIIAGIILL
                     FFALAIPYSKQFYKQGISKSNESE"
     gene            complement(66487..67233)
                     /locus_tag="KR257_000163"
     CDS             complement(66487..67233)
                     /locus_tag="KR257_000163"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903632.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MerR family transcriptional regulator"
                     /protein_id="HBH0028894.1"
                     /translation="MDTYTTSEVADLIGVHPNTVRLYEELNLIPKPKRNTNGYRIFND
                     FHIEQFRFARTALKIEVVQRGLRKDALEIVRTSANRDFDKAISLVNQYLQQLEIEKSN
                     AEEALTIVAQILNGNTPETNKLFLTRKETAEHLNVTIDTLRNWEMNGLLKVKRKQNGY
                     RVYTDEDIKRLKIISALRCANYSLSAILRMLNALSSSPNTNIKTVLDTPKDDDEIISV
                     CDKLITSLKEAEHNAKTMKSHLQIMKKQFS"
     gene            complement(67386..68408)
                     /locus_tag="KR257_000164"
     CDS             complement(67386..68408)
                     /locus_tag="KR257_000164"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728517.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="serine hydrolase"
                     /protein_id="HBH0028895.1"
                     /translation="MNKNNCLDLIFEKVDPSSVGMSSEKLSQLEPLIISQYSNINGII
                     IARKGKIVFEKYYNGYNADDTFHVASVTKSIISALIGIAIDKGYIKDVDQKVVDFFPE
                     YTCSPSEICKKAVTIRHLLTMTAPYPFKNMTESLERLCKQKDWIKYTLNQLGQKGEIG
                     TFKYSSAGTHLLSAIITKTTGKSAREFANEYLFKPIGMKVIPDYDMKDFGFEDFFGKN
                     LKGWAKDRQGYSIGGWGLTLSARDMLRFGFLYLNDGIWNNKRIISKSWIEESVKMNSN
                     EYGYLWWLCKKDGVLWYSAMGTGGNAICCIPQYDLVIAIPSKIVFKPRDRWEFIEKYI
                     LTSIID"
     gene            complement(68408..70828)
                     /locus_tag="KR257_000165"
     CDS             complement(68408..70828)
                     /locus_tag="KR257_000165"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422012.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="excinuclease ABC subunit UvrA"
                     /protein_id="HBH0028896.1"
                     /translation="MKEIKINGAKIHNLKNIDVSIPKDKLVVATGVSGSGKSSLMFDI
                     VFEEGRKQYLQSLGILAGIDSEDKFDNIQGLAPTIAVQQNIIRQSNPRSTVGTRTNIL
                     NMLTLLYSVEGQIMCTMCDTPVSDNLICNNCGYEEERLRPSYFSYNSSDGMCMKCSGH
                     GAYFEINIEKLVLDKHDTLKQVLDRAKITPGYLRVFSKKFNDYLDIQFLQLPEEIRNE
                     VLYGHYENGKKSSSLSKVFHNRYKRGEDLNGVYTMTACSDCNGFKIGEEARRVLLNGK
                     HIGELGKMTILEIDDFLKLLINQGNLNTFGTNLVNDILSKTQHLIESRLGHLSLYREM
                     STLSGGEMQRLFLNSHLDSEMDSLIYVLDEPTAGLHESEKIDILKSLKKLKDLGNTVI
                     VVEHDKNTIEMAEHIIDIGPKAGVEGGQLVYQGDLEGLLQSDKSLTGQYLSGKYPMPN
                     RTSNKNITHTDKIPCITIQNANTNNLKNVTVSLPLGAMVGISGKSGSGKSSLISDTLL
                     PLLRSQFNNHTINNQINSSESEIGEEDDYAVVETIADRLIGTKHISGYSEISQSPIGK
                     NMNSTPASYIGIWDKIRTLFAGQPESLEQGFTAGHFSFNSKGACPKCSGSGYEKVWLG
                     NNLSIDHICSECQGKRFNDESLSIKYKNKNIHDILNMSVSESVHFFKDIPNIVSHLNV
                     LEQIGMGYIKLGQPTPTLSGGESQRIKLAKEIGKKRNGNILYVLDEPTTGLSLYDTSK
                     LIQLLDELVENGNSVIVVEHDIDVLNVCDWIVELGPEGGDKGGYIIAEGSPKTLKENP
                     KSITGRYL"
     gene            complement(70914..71834)
                     /locus_tag="KR257_000166"
     CDS             complement(70914..71834)
                     /locus_tag="KR257_000166"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891624.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AraC family transcriptional regulator"
                     /protein_id="HBH0028897.1"
                     /translation="MTNAKSKKEYLNRICKVQDYIEEHLHEPLSLDELSNIAGFSKFH
                     FHRIFKAIEKETLAQYVNRLKLENATAFLIHRTDMTVTDIAHYFGFTDSAVFSRAFKN
                     YYKISPIKYRNNYSKNCKEPYKISQYNRSISKPKCKNTREVKGEIEILELDNMNTIYT
                     RYTGSYGNLTSTFPKLLERLFTYASEQNLLGLENTQILAIYHDNPQFTQEHQLRTSIC
                     MTIPDNIVVKENDNLGNMIIPSGKYLVGHFDISKSEYSDAWDFMYNEWLSNGNYKLRA
                     SFPFEVYLNNPHNHPQNRHLVDIYLPIEPF"
     gene            72424..73350
                     /locus_tag="KR257_000167"
     CDS             72424..73350
                     /locus_tag="KR257_000167"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434288.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="conserved phage C-terminal domain-containing
                     protein"
                     /protein_id="HBH0028898.1"
                     /translation="MSNSFYQLNSAVLYFNEKRDVNRIRFNHYVMRKENIQRLKGTLP
                     RGQFMMTVRKAASDLDVSISTISRLVNEFIDLGILRLISRGVKGNCCSVYSYVCSESS
                     NAEIVTKNGDIFKNIEKYIDATINNNQKTMKYKHRNELFKNSNTNIYSRINQESIDKD
                     YDLIIHTGYETENETKKKELLKNNLNKKNLNKNTFENSDEDLTEDSTYKNPESIHEII
                     IRKLNSESGKNFKADLSITKALIDKRLKEGYSLEDFYKVIEAKVRRWRYTDMEIYIEP
                     TILFGYEFESYLNEESSLSACNYGDMCYEDMY"
     gene            complement(73733..75385)
                     /locus_tag="KR257_000168"
     CDS             complement(73733..75385)
                     /locus_tag="KR257_000168"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861871.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell wall-binding protein Cwp21"
                     /protein_id="HBH0028899.1"
                     /translation="MNKKNLAILISGMMFFSSSSAIFADNTTKQERLIGKTRYETAVE
                     VSKLGWVQSKTAIIVNGNSIQSALCANPFAKLKNAPILLVNNNSIENSTKAELKRLGV
                     DNVYIVDSGNSISSKVENEIKSLNIKINKIVGNNIYEMSTNVLKEIDKIKKIENVAVV
                     NGLKGLSDAVSIASPAAIHNMPIILVSDENSNDSSINFLNNRSIKKSYIVGGNKILSD
                     NTVKKYPNRERISGSDRNNTNAKIIDKFYKDKKINNVFVAKDGINQENALVDSLSIGV
                     LAAKENSPIMISNGSLVNSQKEFIKNKDIDEITQVGGGYNQKAFEDILKLKNVNIRNK
                     TKKISLIQAKEILKQALPGSNILVCYYDEDDNEYDCKVIKDNILYEIEIDAYSGKIIE
                     IEKDDDLNDNNLGTQNISLDKAKSIALDAIPNGNLIYCKYDAEDNEYEAKVIKNKKTY
                     ELEISAFDGRIVDIDMDNDSDDDFDDNDKNNSNTNDNSSIISAEKAKSIMLDKVPGGK
                     IVKFKYDEDDKEYEGEIIKGKTEYEITINAITGKILEFEIDD"
     gene            75984..77105
                     /locus_tag="KR257_000169"
     CDS             75984..77105
                     /locus_tag="KR257_000169"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434286.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aldo/keto reductase"
                     /protein_id="HBH0028900.1"
                     /translation="MEAKKLGFGLMRLPIKDENDVTTIDMEHLNKMVDTFLERGFTYF
                     DTAYVYHMGKSEIALRESLVKRHKRESFTIATKLPLMALKKKEEQETIFNEQLEKCGV
                     DYFDYYLLHNIGVSHYEVAKKFDSFKFIEEKKKEGKIKNIGFSFHDSAELLDKVLSEH
                     PEVDFVQLQINYLDWDNESIQSRKCYEVAEKHNKPVIVMEPVKGGTLAKIPEKAEKLL
                     NDYNPDMSISSWAIRFAASKDNVMMVLSGMSNMEQLLDNTGYMQNFKPFVQEEYNIID
                     EAVEIINESILIPCTACQYCVEGCPKNIAIPNYFALYNAEKQALNTGFSTQMVYYNNY
                     TKTYGKASDCIECKQCEESCPQHIKIIDALKNVAETFEK"
     gene            77141..77554
                     /locus_tag="KR257_000170"
     CDS             77141..77554
                     /locus_tag="KR257_000170"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434285.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MerR family transcriptional regulator"
                     /protein_id="HBH0028901.1"
                     /translation="MTISEVSKKYELSADTLRYYERIGLIPPVNRNKSGIRSFTEEDC
                     EWVNFIKCMRGAGLSIETLIEYVAMFQQGSSTIKARKELLIEQRNQLAKRIEEMQKTL
                     ERLNFKIDRYEEGIIEKEKVLKSSRNKKMEAVSYE"
     gene            77547..78086
                     /locus_tag="KR257_000171"
     CDS             77547..78086
                     /locus_tag="KR257_000171"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434284.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flavodoxin family protein"
                     /protein_id="HBH0028902.1"
                     /translation="MSKNVLIVSASPRKGGNSDLLCDQFIQGVLESKNQVEKIFLKDK
                     DINYCTGCGACYEKEANCSQTDDMGEILEKMIGADVIVLATPVYFYTMNAQMKTMIDR
                     TCSRYTEICDKDFYFIVTAADENVADMERTIEGFRGFTSCLNGSKEKGIVYGVGAWNV
                     GDIKGSKAMKQAYEMGKLA"
     gene            complement(78286..78771)
                     /locus_tag="KR257_000172"
     CDS             complement(78286..78771)
                     /locus_tag="KR257_000172"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434280.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0028903.1"
                     /translation="MSKSELTAETTEEMLEVLSGKDYDIACHLHELGKSLDCKIEPKT
                     GARSYKIVYSTKKPKRSLFTIECNEKKWRVKANLFHLNTYKDAVEECSKTIKDSITKT
                     RTCKKCNSKCIGGSSFELDGKSYLTCIGSGHYFANMEEMDWKNLEKLITKENNIMQES
                     V"
     gene            79676..80053
                     /locus_tag="KR257_000173"
     CDS             79676..80053
                     /locus_tag="KR257_000173"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003483933.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RidA family protein"
                     /protein_id="HBH0028904.1"
                     /translation="MSKVVIATEKAPGAIGPYSQAIQVGNIVSTSGQLPIDMKTGELV
                     SDPKEATKASLDNVKAILEQAGTSMDKIFKTTVFVKDLKDFNDINEVYATYFKENPPA
                     RSCVQVAQLPKDAVLEIEAMAVL"
     gene            80449..82254
                     /locus_tag="KR257_000174"
     CDS             80449..82254
                     /locus_tag="KR257_000174"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891601.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sigma 54-interacting transcriptional regulator"
                     /protein_id="HBH0028905.1"
                     /translation="MLSKLKEFQQEMIKYTETVASVLDVDIEIVDDRLIRISGTGLYK
                     SKINESVVTEGFIYDNVIQTGQELVVLDICDNQLCIECSHYMKCLNKVIIAVPIKYNN
                     RTIGVIGAISTDKTKKVEISAKIDNYLKFVNHICDLISMKIEEHEASKNSSRKMDMMI
                     EIIENVEKGVIILDINSKISYINNIALKKLDIDKNIIENIVNIVSVESSSNGHELLEI
                     DIDNKIYNINAKIIPVYPYINQYDKIIIFDKTYINHKGHGKVNSGWGNSDIESIIGNS
                     EAMLKVKERTKKLAKSNSTVLITGESGTGKELIARAIHAEGSRWNKPFIAINCAAIPE
                     NLLESELFGYIKGAFSGASSGGKVGKFELANEGVIFLDEIGDLSMPLQAKLLRVLQER
                     KFARIGSNKLIDLDIRVIAATNKNLLKLVNEGKFRDDLYYRLNVIPINLPPLRERKDD
                     IEAIMMKFASKYSLELGIQLNKIEENVMNMLINYNWPGNIRELENAVEYMMNLVGDDG
                     IIYKDMLPLDILNYYNINGNIYKNKDVNIIFEDDIVGGIVENQERILSIKELELTYIN
                     KLLNKYGRDTKTKKKIAKDLGIGLATLYRKLEEEQ"
     gene            82331..82868
                     /locus_tag="KR257_000175"
                     /pseudo
     CDS             82331..82868
                     /locus_tag="KR257_000175"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003427977.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="2'-5' RNA ligase family protein"
     gene            83482..84696
                     /gene="dpaL"
                     /locus_tag="KR257_000176"
     CDS             83482..84696
                     /gene="dpaL"
                     /locus_tag="KR257_000176"
                     /EC_number="4.3.1.15"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004453094.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="diaminopropionate ammonia-lyase"
                     /protein_id="HBH0028906.1"
                     /translation="MREIKWKLNNLPKSEEKEKGIEFLKDEEIAKAKAFHESFPQYEK
                     TPLVKLDNLAKSLGVSGIYVKDESYRFGLNAFKVLGGSYSMGRYLAQRLNTDISELGY
                     DKLTSKEIKEKLGEITFFTATDGNHGRGVAWTANKLGQKSVVLMPKGSSEFRLNKIKG
                     EGADASITDLNYDDAVRLANDYAEADDHGVMVQDTAWDGYEEIPAWIMQGYGTMAKEA
                     IEQLKEYGVDRPTHVFVQAGVGSLAGAVQGYVASIYDECPITVVVEADEADCYYKSAE
                     AGDGKPRFVGGDMPTIMAGLACGEPNTIGFEVLKNYSSAFVSAPDWVSAKGMRILGNP
                     LRGDEKVISGESGAVTTGALVSILESEDLKDLREALKLDENSKVLLISTEGDTDPDKY
                     RDIVWNGECQSK"
     gene            85029..86216
                     /locus_tag="KR257_000177"
     CDS             85029..86216
                     /locus_tag="KR257_000177"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893427.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YgeY family selenium metabolism-linked
                     hydrolase"
                     /protein_id="HBH0028907.1"
                     /translation="MLNETRKKQLTEVCQDLIRNASYSGQEENVVKAIEENFALLGFD
                     SWSRDRYGNIVGCIKGNKPGKKILFDGHIDTVPVPDASKWSVPPFEARIVDGKIYGRG
                     TSDMKGQVSAMMAAVSYFAEDTNKDFEGELYVAGVVHEEIFEGVSAREISKAVQPDYV
                     VIGESSELNLKIGQRGRGEIVVETFGKPAHSANPEKGINAVYKMANVIQKIQQLVPPT
                     HPVLGDGILVLTDIKSSPYPGASVVPDYCKATFDRRLLVGETREGVLAPIQALLDEMM
                     KEDPELNAKVSYAVEKADCYTGNTIESERFFPGWLYDEEDEFVQAAYKGLKEAGIDSE
                     ITQYSFCTNGSHYAGEAGIRTIGFGPSKENLAHTIDEYIELDQLFKGAEGYYGILKSV
                     YKK"
     gene            86232..87815
                     /locus_tag="KR257_000178"
     CDS             86232..87815
                     /locus_tag="KR257_000178"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421978.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="D-aminoacylase"
                     /protein_id="HBH0028908.1"
                     /translation="MRTLIKHGLIVDGNKTPAYEGDILIENEKILKISQDLNEEADKV
                     IDAKGRVICPGFIDTHSHSDLVILVNPYNEVKIRQGITTEVLGQDGISMAPLPQEHIS
                     SWRKNLAGLDGESDEIDWKYETTENYLKMMDYNGVGLNETYLVPHGNVRMEAMGLEDR
                     PATKEEIQKMCEITERELKAGAIGLSTGLIYIPCAYSLTEEIIEMCKVVAKYDGVFVV
                     HQRSEADTILTSMEEIIEIGKQSGVKVHFSHFKVCGKANWKYIPQVIELLEKAEKEGI
                     RVSFDQYPYAAGSTMLGVVLPPWAHSGGTDKLIERLSDENERAKMKKDIANGIEGWDN
                     FIEFAGIDQIFVTSVKTEKNKDTIGKSLLEIGKMRGKDPLDATFDLLKEEENAVGMVD
                     FYGLEEHIIGFMKRDEQNVCTDGLLAGKPHPRAYGSFPKILGRYVRELNVLTIEEAVY
                     KMTKKAATSFSIKDRGELKEGYFADIVIFDKDTVSGCDDFINSMQYPTGIDYVIINGN
                     CVVEEGKYNKIKAGKVLKN"
     gene            87843..89171
                     /gene="ssnA"
                     /locus_tag="KR257_000179"
     CDS             87843..89171
                     /gene="ssnA"
                     /locus_tag="KR257_000179"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898311.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="putative aminohydrolase SsnA"
                     /protein_id="HBH0028909.1"
                     /translation="MILVGNGRLISQDSLNPYMEDGCVVINDNLIEDIGTTEEMKAKY
                     PVHEFIDAGKKIIMPGLINSHMHIYSSFARGMAVPGKPSENFLEILNNLWWRLDKQLT
                     LEDTKYSAYATYIECIKNGVTTVYDHHASPNAIEGSLFTISDVAKDLGIRTCLCYEVS
                     DRDGGNTIQQGINENVNFIKYAQKDDTDMIKGMFGLHAAFTLSDDTLNKCASEMAGLD
                     TGYHVHVAEGLADLQYNVDKYGKRVLERFNDFGVLKEKTIAVHCIYISAEEISLLNKT
                     NTFVVHNPESNMGNAVGCSPAIELLKRGVTVGLGTDGYTSDMFESLKVANIIHKHHLK
                     DPRVGFEESQTMLFDNNRKIAKAYYKNDLGVLKKGAYADVIVVDYIPHTPLTENTIGG
                     HTIFGMSGRSVDTTIINGKVLMKDRKLINIDEESILAKSRELSQNLWNRI"
     gene            89316..90668
                     /locus_tag="KR257_000180"
     CDS             89316..90668
                     /locus_tag="KR257_000180"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429559.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="purine permease"
                     /protein_id="HBH0028910.1"
                     /translation="MSRDKSPKIAPVDERLPVSKSWVFSLQHVLAMCAGAVAVPMMIG
                     SAARLDHASIVFLINACLFMAGIGTLIQSVGIGNIVGAKIPVIEGTSFAAVAGMTAIA
                     SSYSDSQVAIQTVFGSVIVAGLFCILLAPVFEKLIRFFPSVVTGTVVMVIGISLFPVG
                     IKWITDNKLEAVEPNSLALALAVLAITLLSFKFLKGIWNSTAILVGIVLGTLLSMAVG
                     MADFSAVNGVGWLNLNVPLKFGMPRFEPSAILSLCLIMLVLMTESVGNMIAIHEMVDK
                     EVTGKNIKRGLFGDGISTALSGIFNSFPITPFGQNTGIVGLTGIKSRFIAVYAGVILL
                     VLGFLPKFAAIIGAIPKPVLGGVGFAMFGMVMVGGVKTLSKVKFDGTKNGVIVAVSVG
                     LSMIPLTNPDFYHNFPTWVQTIFHSGITTGSLSAVLLNIFFNELGSKKEKNNKVEEAK
                     "
     gene            90860..91969
                     /locus_tag="KR257_000181"
     CDS             90860..91969
                     /locus_tag="KR257_000181"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434155.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="4Fe-4S binding protein"
                     /protein_id="HBH0028911.1"
                     /translation="MANLKVNLYGMEFLNPIMTAAGPGAKDGALCQEAAKGGAGAICT
                     KTISVLPADVPRPCMAKTNSGFLNTELWSELPKEQWIEEEYKKVKETGLPVIVSMGYS
                     AEQIAEVAPLVKPYADAVELSTHYVGTDVAPIVNALKAAKAVLDVPVFMKMSPHTDIQ
                     TIAKAVEEAGADGLVMINSFGPCMAIDVNTGYPIMGSKAGYGWLSGAPIRPLAIRCIY
                     EASQVVNIPIIGVGGITCGKDVAEMMMAGASAVQVCTEAILKGPSIYGKIAKELNEFL
                     DENGYADVNEIKGLTHKKMAARGFRTHSVAPVVDDNKCIKCKQCVTSCVYEALEVTDK
                     LNIDADKCFGCGLCVTRCPKGALSICYNQVEAMNE"
     gene            92252..93643
                     /gene="hydA"
                     /locus_tag="KR257_000182"
     CDS             92252..93643
                     /gene="hydA"
                     /locus_tag="KR257_000182"
                     /EC_number="3.5.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898309.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dihydropyrimidinase"
                     /protein_id="HBH0028912.1"
                     /translation="MGIVLKGGKVVTSEKTYCADVRIEDEKIVDIGLDISKENDEIVD
                     VSDSYVIPGGIDTHTHFDLDTGVTKTADNFETGTKAAIVGGTTTILDFATQAKGCSLK
                     DGLEEWHEKAKDKSYSDYGFHMAITDWNDSVCNEMEDMVKEGVSSFKLYMAYKGSLQV
                     DDGVIFEALRKAEEIGGIIGFHCENGDIICELVDKAKSENNLSPKYHQLTRPAIMEAE
                     ATSRLMKIAEVANSKVYVVHLSCKESLEEVLKAKQRGVDVIVETCPQYLLLNDELYDL
                     DGFESAKYVMSPPLRNKENNEILWNAILDNQIDTIGTDHCSFNYKGQKELGINDFSKI
                     PNGSPGVEHRMSLLYTYGVCKNKISINKMVEVTSTNAAKLFGMYPNKGTIEIGSDADI
                     LVLNPNKKSKIEAKKQLQNVDYTPYEGYEVDCQIEHVYLRGKEVVRDGELICNTPSGR
                     YINRRLTKGAREW"
     gene            93637..96198
                     /gene="xdh"
                     /locus_tag="KR257_000183"
     CDS             93637..96198
                     /gene="xdh"
                     /locus_tag="KR257_000183"
                     /EC_number="1.17.1.4"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421967.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="selenium-dependent xanthine dehydrogenase"
                     /protein_id="HBH0028913.1"
                     /translation="MVEFILNGEKVVAKEGKKLLDFLREDMNITSVKNGCSEGACGTC
                     MVIIDGKATKACVFKTDKLAGKNITTIEGLSERERDVFAYSFASQGAVQCGFCIPGMV
                     ISSKALIDVNNNPTEDDIKKALKGNICRCTGYVKIIKAVDLAAKIFRENIDVPKVNCK
                     GLVGENLPRVDAVGKALGYSEYVDDMRIEGMIYGSAVRAKYPRALVKKIDIEEAKAYP
                     GVVAVLTAKDIPGTIKVGHLKKDWDTLIPEGEITRYLGDGIVLVAAETREALEEAKKL
                     VKIDYEELTPLSTTEDALREDAPKIHETGNILVKEHLVRGNAKEKIENSKYVVTKRYT
                     TPATEHAFLEPECAVAGPYEEDGVIIYSTDQGVFATQHECADMLGLPYEKVRVINKMV
                     GGGFGGKEDMSVQHHAALLAYHTKRFVKVQLTRKESIIVHPKRHATEMEFTTACDENG
                     YLTGMKATIISDTGAYASLGGPVLQRLCTHAAGPYNYQDIDITGTAVYTNNPPGGAFR
                     GFGVTQSCFATECNLNLLAEMVGISPWEIRYKNAIRPGQVLPNGQFADEGTAMAETLE
                     AVKEEYEKHPRAGIACAMKNSGVGVGIPDVGRCRLVIKDGKVHIRTSASCIGQGLGTV
                     MTQVVCETASLLPENVVHEVPDTHLTPDSGNTTASRQTVFTGEATKVASNKLKEALDS
                     GKTLLDLEGEEFYGEYESITDKMGCDKENPVSHVAYGYATQVVILDENGKLEKVVAAH
                     DVGRAINPISLEGQIEGGVVMGLGYALTEDYPVVNSVPTAKFGTLGLFKSTDIPEIQA
                     LIVEKNKDLLAYGAKGVGEICTVPTAPAVQNAYYVFDKEFRTELPLQNTPYSKKK"
     gene            96446..97792
                     /gene="rpoN"
                     /locus_tag="KR257_000184"
     CDS             96446..97792
                     /gene="rpoN"
                     /locus_tag="KR257_000184"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421965.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RNA polymerase factor sigma-54"
                     /protein_id="HBH0028914.1"
                     /translation="MNFNNSLELTQSQKLIMTTQLKQSLSILNMSKLELEEEIKREAE
                     NNPLVEVEKSGEINWEEYIKDMDRSRRLDRTEISYNPDNEVNLENLVKYSSNLYEDLK
                     FQISLYKLTDKELEVCEYIIDSLDEDGYLRTEEKVIVDTLKIDEELFEKCLISVQQLE
                     PSGVGARSLSECLMIQMASLGIYNEILEEIVTKDLNLIANNKYKEISKKYNMSLQKCV
                     ELINIIKTLDPKPGRTCSVEKSVYIQPDVTVEKIDDEFIVYLNEKDSYQIRINSYYKD
                     ILKNSQSDESAKEFIKERLNSATGLMKNIESRKTTVLKIAEEIVKAQDEFLRKGTKYI
                     KPLKMKDIAEKLEFHESTISRGVNGKYMLTPFGVYEFRYFFSSAIETENNEMASSTSI
                     KKIIKETIKDENKKKPLSDDHISKLLKEKGINVARRTVAKYREELGIPSSSKRKEY"
     gene            98588..99610
                     /locus_tag="KR257_000185"
     CDS             98588..99610
                     /locus_tag="KR257_000185"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429564.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcriptional regulator"
                     /protein_id="HBH0028915.1"
                     /translation="MKNLLEIQKKLIPQAIELMERRYSILRQISLSEPIGRRTLSNVL
                     EISERIIRSETEFLKEQGLIDVAVSGMTITKEGSDLLDKLKDIMSDIMGLSKLQDRVR
                     EKLGIKRVILVPGSCDENGSLLKDVTRYGCEYFLGILKDGDIVSITGGSTMLEFSNVI
                     KTDKRYPNSTIVPARGSMGTDVEMQSNNIVASISKKLHSNCKLLHIPDELDESAMKTL
                     SQVPEIKTTLEYIKRTDILVFSIGRADVMAKRRKLPEDKVDEILSKNAVGEAFGYYFN
                     KDGEIVYKLNTVGIDLETVKQVKETIAIFAGTEKVEALLAISNMHKNMVLVTDEESAY
                     KILSLL"
     gene            99670..100677
                     /gene="gap"
                     /locus_tag="KR257_000186"
     CDS             99670..100677
                     /gene="gap"
                     /locus_tag="KR257_000186"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421962.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type I glyceraldehyde-3-phosphate dehydrogenase"
                     /protein_id="HBH0028916.1"
                     /translation="MVKVAINGFGRIGRLALRKMMEQQDKFEVVAINDLTDAKMLAHL
                     FKYDTAQGRFNGEIEVKEGAFVVNGKEIKVTAERNPADLPWAELGVDIVLECTGFFTS
                     KDKAEAHIQAGAKKVVISAPATGDLKTIVFNTNSDILDGSETVISGASCTTNCLAPMA
                     KVLNDKYGIEKGLMTTIHAYTNDQNTLDGPHPKGDLRRARAAAGNIVPNTTGAAKAIG
                     LVIPSLKGKLDGAAQRVPVVTGSITELVCTLGKNVTVEEINAAMKEASNESFGYTEEM
                     LVSSDIIGISYGSLFDATQTKVMEVDGKQLVKVVSWYDNEMSYTSQLIRTLGYFAQLA
                     K"
     gene            100899..102101
                     /locus_tag="KR257_000187"
     CDS             100899..102101
                     /locus_tag="KR257_000187"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429565.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphoglycerate kinase"
                     /protein_id="HBH0028917.1"
                     /translation="MSMLNKKTIEDIDVCGKKVLVRCDFNVPLQDGVITDENRLNGAL
                     PTIQYLISKGAKVILCSHLGKPKGEAKPELSLAPVAKRLSEMLGKEVVFAADDNVVGE
                     NAKKATEKMENGDVVLLENTRYRKEETKNEENFSKELASLAEIFVNDAFGTAHRAHCS
                     TVGAGEFLQERVCGYLIQKELKFLGEAVANPVRPFTAILGGAKVSDKLAVINELLEKV
                     DNLIIGGGMAYTFLKAQGYEVGTSLLEIDKVEYAKEMMEKAKNKGVNLLLPVDVVMAD
                     HFAPDATPIVTEDANVKEDYMGLDMGPKTIANFVKTIKESKTVVWNGPMGVFEFENFA
                     NGTLSVARAMAELTDATTVIGGGDSAAAVNQLGFGDKMTHVSTGGGASLEFLEGKELP
                     GIAALDNK"
     gene            102127..102870
                     /locus_tag="KR257_000188"
     CDS             102127..102870
                     /locus_tag="KR257_000188"
                     /EC_number="5.3.1.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891583.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="triose-phosphate isomerase"
                     /protein_id="HBH0028918.1"
                     /translation="MRKPIIAGNWKMHKTIKEALEFVNEVKDKVNSDKVEAVICAPFT
                     LLKDLKEATKGTNIKIGAQNMHFEEKGAFTGEVSPLMLKEIDMDYVVIGHSERRQYFN
                     ETDETVNKKVLKALEVGIDPILCVGETLEQREAGKTKDVCKVQVEKALENVLKDDLAK
                     VVVAYEPIWAIGTGKTATAEDANDVISYIREVIKGLYGELANEVRIQYGGSVKPSNVA
                     EIMGQSDIDGALVGGASLASNDYLDLVNF"
     gene            102879..104411
                     /locus_tag="KR257_000189"
     CDS             102879..104411
                     /locus_tag="KR257_000189"
                     /EC_number="5.4.2.12"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003228330.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="2,3-bisphosphoglycerate-independent
                     phosphoglycerate mutase"
                     /protein_id="HBH0028919.1"
                     /translation="MMKKPVALIIMDGFGYNKDVKGNAIAESKTPNLDRIKKEYPNTL
                     INASGLDVGLPDGQMGNSEVGHTNIGAGRIVYQDLTRITKSIKDGDFFTNKVLCEAMD
                     NAKENSLHVMGLLSDGGVHSHIDHLKAIIKMAKDKGVQKVYVHAFTDGRDTDPQSALE
                     YAKEVQASMDEIGVGEFATVSGRYYAMDRDKRWERVELAYNAMVRGIGEKANSIEEAI
                     QNSYDDGKNDEFIMPTVIMKDDKPVGSIKENDSIIFFNFRPDRARQITRALVCEEFDG
                     FKREDIKNFFVCLTEYDITIENVHIAFGPQSLANTLGEYLAKNGKTQLRAAETEKYAH
                     VTFFFNGGVEEPNKGEERLLIPSPKVATYDLKPEMSAYELTDKALDKLGEDKFDFIVL
                     NFANPDMVGHTGSIEAAIKAVETVDTCVGRLIDKIVELGGSAIITADHGNAEYMLDPE
                     TGKTVTAHSINPVPFIVVGQEYESAKLLDGGRLSDIAPTVLDMMKLEKPEEMTGHSLI
                     SK"
     gene            104999..106291
                     /gene="eno"
                     /locus_tag="KR257_000190"
     CDS             104999..106291
                     /gene="eno"
                     /locus_tag="KR257_000190"
                     /EC_number="4.2.1.11"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898301.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphopyruvate hydratase"
                     /protein_id="HBH0028920.1"
                     /translation="MSVIELVYAREVLDSRGNPTVEVEVVLEDGAMGRAIVPSGASTG
                     AFEAVELRDGDKGRYLGKGVETAVANVNEIIAPEIEGMDAFDQPAIDAIMIELDGTPN
                     KGKLGANAILGVSMAVARAAADEIGLPLFQYLGGVNAKQLPVPMMNILNGGEHADNNV
                     DVQEFMILPVGACCFKEGLRMGAEVFHSLKKVLGEKGLACGVGDEGGFAPNLGSNREA
                     LELIVEAITKAGYKPGEDVMLGLDVAATEMYNKETKKYVLAGEGKELTAAEMVALYED
                     WSNNFPIITIEDGLDEEDWDGWKLLTEKLGNKLQLVGDDLFVTNTERLEKGIENGVAN
                     SILVKVNQIGTITETLDAIEMAKRAGYTAVISHRSGETEDSTIADLAVAVNAGQIKTG
                     APSRTDRVAKYNQLLRIEEMVGEQARYCGLKSFYNLKK"
     gene            106884..107108
                     /gene="secG"
                     /locus_tag="KR257_000191"
     CDS             106884..107108
                     /gene="secG"
                     /locus_tag="KR257_000191"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421948.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="preprotein translocase subunit SecG"
                     /protein_id="HBH0028921.1"
                     /translation="MSNILMGVQVVLGILLVISIMPQDSKNALPSEFGGEGSQAYFKP
                     KGKQAFLARVTKITAVLFFINALALLIVKK"
     gene            complement(107492..108430)
                     /locus_tag="KR257_000192"
     CDS             complement(107492..108430)
                     /locus_tag="KR257_000192"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861865.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AEC family transporter"
                     /protein_id="HBH0028922.1"
                     /translation="MENLILSINVVLPLFLTMSLGYVLKKLGLFDTHTLNKMNNVCFK
                     SFLPLLLFFNIYNTDLDGSLNFRLMAVAVIIIFSIFLILVFIIPKIEKDNKTRGALIQ
                     GVFRSNFVIFGIPVTISLFGDKSIGVTSLLIAVIVPMFNVLSVVILEIFRGGKVNIKH
                     MIKSVLTNPLIIASFIGLTMLILNINIPTFLHKTIGDISKIATPLSLIILGGSFSFSA
                     IKGHINPIILGVCGKLILVPAIFLPISIFLGFRNVELASLMIMLSAPTAVSSFTMAQQ
                     MDSDSELAGQIVVFTSGFSIITVFLIIFILKQNNLI"
     gene            complement(108418..>108801)
                     /locus_tag="KR257_000193"
     CDS             complement(108418..>108801)
                     /locus_tag="KR257_000193"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434143.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="VOC family protein"
                     /protein_id="HBH0028923.1"
                     /translation="EHVVITNNNIENYINFYKKFGFSSKEMSKNYKLNARNIKINLNI
                     KGYKFLPYVKNLQASRDNLCFKINTNIDEPKKYLEQNEIQIKRGIVECTGVFGNMKSI
                     YLKKTNGNLIELSNHRITESKPWKI"
BASE COUNT        41916 a        12841 c        19131 g        34913 t
ORIGIN      
        1 tattttttca ccttttgatt catactttgt agaatggtgt attttctaaa actgattata
       61 agacaagttc attcaaatta gcatttttat atcatataaa taattgttcc ccctaaataa
      121 gatttagatg tatagtatta aaatcaaaaa gtataaaata aaattgatgc ttaatcatag
      181 ataaatatta ataaaatata caaggggatt gtctaataaa aagataatct ccttttttac
      241 aaataattct aaattgtgat ataaatctaa aaattttatc ttaacattta accatttaat
      301 gataataatt gatataataa atataaatta aatatatggt gtacttattt tatgttttta
      361 gcaagaaata tagcatttaa aagataaatt gtgcaactta aatcaaagtt taagatgaac
      421 tattaacata gatatattaa aaacttttgt aatggagaat atatgtgata tgaataataa
      481 agttaaggtt gcagtattag atacaggaat agacaaagaa catgattact taaaagataa
      541 tttagttgga ggaattgctt ttgaatgtat gcatgattat atctttatat cagataaatt
      601 tgatgatgaa gatggtcatg gaactgcttg tgcatcaata ataaagaaag agtatgaaga
      661 tgtagagtta tttgtaataa aaattttgag aaaagatggt attacaaata taaaagttct
      721 tgaagaagca ttaagatacc ttttagacac taacataaga ttaattaatt taagtttatc
      781 agtcatagga gtagaaagtg ttaagggctt atttgaagtt tgttatgaat tgtttagaaa
      841 aggaaaaata atagtatgtt cactcgctaa tgattttgac ttaagttatc cagctatgtt
      901 taacaatgtt ataggtgtaa gaggatttac tttagatgga gatgattcat tttggtacaa
      961 caaaaaatat gatgttcaat gtgttatgga tagcaattca tatataagtt gtgatataaa
     1021 taattcctat agattaccac caaaatgtaa tagttattta tcagcaaagc ttactggtaa
     1081 aatagctaag atattatcag aaaaaccagg cataacaata tctgatttaa atgataagct
     1141 tgaatcatta gcaactagaa atcattggga tagttgtgat tttgatgagt gtagtagaat
     1201 tgtaaacttt aaattggatt tgtatgacaa agaaaatgct ctttttatga aagttgctga
     1261 cgttgttagg gattgcttag atattgaaga gaataatgaa aaactcttta agggtagcct
     1321 ttttaataag gagataggct tggtttatga taattgtttt aatctgttga aaaagctaga
     1381 gcatagattt gacataaagt ttaattatat ggacatctca aaatatgact tagtttcaat
     1441 atatacactg actgaattag tggaaagata taaaaactta taaataaaga tttgtagcta
     1501 aatttaatgt agaaggtatt aaattatatg tattctttgt cggtagatta aaagtaaaaa
     1561 atatactata attagatagc ataagagaaa atgccaatac agggggagtt agataatgaa
     1621 atatgaagaa gcattagagt acatatcaca aactaataaa ttcggtataa gattaggatt
     1681 agaaaatatc ggaaagttat tagaattatt aggaaatcca caagaaactt tgaatataat
     1741 acatgtagct ggaactaatg gaaaaggttc tgtgtgttct tttgtttcta atatactaag
     1801 agagtgtgga tataaagttg gtttatatac atctccatat ttagaaactt ttactgagcg
     1861 tataagagta aatggacaaa atataccaca ggatgatgtt gctagaataa ttgagttaat
     1921 aaaagaaaaa atagagatta tggtaaaaga aggctatgca tatccaacag aatttgaagt
     1981 ggttactgca atggcatttt attactattc agaacaaaag gtagactttg tggcattaga
     2041 agttggttta ggtggcagat atgatgctac aaatataata acaaaatcac ttgtaagtgt
     2101 gatagtatct ataagtttgg accatacagg tatacttgga gatacaatag aaaaaatagc
     2161 gtacgaaaag gctggaataa taaaggaaaa tggagtagta ctagtatatg accagactga
     2221 tgaagcaaag gatgttataa agtcagtttg taaagagaaa aaagctaaat atatagaagt
     2281 tgattttgat gatataaaca taaaaaaatc agatataaat tctcaaatat acgattgtac
     2341 tgtaatgaaa gaaacttata gagaccttga aataaaattg ataggcgaac atcaaataaa
     2401 caattctatc ttggcaatta gtgtaataaa atatctaaaa gacataaata aattagcaaa
     2461 tataaatgaa gaatctataa gaaaaggact tataaatact aaatggccag gaagaataga
     2521 aaagataaaa gaaaatccaa tttttataat agatggtgca cataatgaag atggagcaaa
     2581 atctttggca aaagcacttg ataagaattt taaaggtaga aaattaacct tattaatagg
     2641 tatgttagaa gataaagata ttgatagtgt tttagagata ttgttgccac attttaataa
     2701 ggtaataaca acaacaccaa gtaacccaag agccataaat tcagatatat taagagaaaa
     2761 agtattaaaa tatgtagatg atgtaacatc aaagcatgag atagaggatg cagtaaatta
     2821 tacattagaa acatcaagtg aggatgatat tataataagt gcaggttcat tatatatgat
     2881 tggtacagtg agaactttag taaagaaatt ataattttat aaaataagta tacaaataaa
     2941 aatataaaaa agagttgtct aaaaaatgga caactctttt tatataaaat aagtttttaa
     3001 taattttact gatgtttata taagtaatta tatagattga cgtatagctt tagataattg
     3061 gtctgggcaa gaagtacctt ttccaccaca gtcaatacca tttaatttat cagcaacttc
     3121 aagagcattt tggccaatta ttaagcttct aagtcctgat aaattaccat tacatcctcc
     3181 tataaattca gcatcaacaa tcacattatt ttcatcaact tcaaaaatca tttctctaca
     3241 acatacacca cttggattaa atgttacttt cattaaaaag acctccatta aatattattt
     3301 ctttttttaa cattaataat aataccaaat atatgcgtaa taatgcaact ataaagcata
     3361 atacaagcta atgaaataat atattattgt agtatatgta ttgtagagag gaggggttat
     3421 atgaaaatct atatttctaa ctacttatca aagagtatta gcatagttga ttattctaca
     3481 cttgaactag aaaaagaaat agtattagaa gataatatat atccacacca tttttgcata
     3541 gaaaaagaaa aaaatttaat atacatacct agttcaagta atgggatact ctatgtctta
     3601 gatttaagta atgataaaat aattgatact gtctctatag gaggaagtct tagtcaagtt
     3661 gtacttagcg ataatgaatt gtttgtggca aatgaagatt ctaatagtat atatgtacta
     3721 gataaaaaca cattaaatcc aataggaatt attggagttg ataatatgcc acatggattt
     3781 gactttgata gagaaagcaa aaagttatat gtaccgtgta taaactcgat agtatgtata
     3841 gatacaatta ataaaaatat acaaaagaaa ataaatatgg actttagagc ttggcatata
     3901 gaacttgata aacaaaagaa agaaatgtat atatcaacac ttgatggaaa gcttataata
     3961 atagatgaag taagcatgga tataaaaaag gtattatatg aatttttatt accagtagaa
     4021 ataagattta attatagtgg caaaaaagtt tatgttgctg atttgggtta taataatgta
     4081 agaattttag attatacaac gagtagatac attggaaata ttgaaataaa tgggattccc
     4141 caaggattag aaatatctaa agatgaaaag ttactatttg tatcagatac acaagaaaat
     4201 tcagtaaaag tttatgaaac tgcaaataac aaattaataa aagaaatcaa ggtaggaaaa
     4261 gagcctacaa ctataatttg tttgtaggct ttaatgtatg tctcttataa gtaaatcgat
     4321 aacttcggca tacatataag atgcattatt tttccagtta ttgcaaataa gttttgcttg
     4381 tttctctgat gaaacattta gatttaaatc tattaagtta gactgatttt ctatgactct
     4441 aaggttgaca ataaattcat tatcactttg ttttacaaaa ctagacttta cttgagtatc
     4501 tgctagtaga ttttctttgt tagaatctat atacttgtct attttttcag taacactagt
     4561 aggtattcga ttaaagaagt attctagact ttctacgcct ctttgagtaa gagcataata
     4621 ttctctgtca gagtctttat atgtagtcaa aaacttagat tccataagct gagataaaag
     4681 ctgttgtaat gaaaaataat tcatcatctc agtctctaat actacttgag ttatttgaga
     4741 attagttaaa tccattttaa ttttttctaa tatatataaa attaaaagtt tgtgataggc
     4801 taattcttca gacgagtttt caaacataaa tatcatcctc cgtcaaacta tttctatata
     4861 taatatatta aactaatttg tacaaaatta aaagaacaat ttgtattgta ttattaatct
     4921 ttaataattc atataaaaac aattttataa ataaatatag aaaaacaggg ctgctaatta
     4981 gcagccctgt tgatacccag gtgtcaaaat ttactattta ttttccagcc atttgtcttt
     5041 cagccatttc aactaatttc ttagtcatat atccaccaac atatccattt tctctagctg
     5101 ttaagttacc tttgtctatg ttttcatagt tagataaacc tatttcgtta gctatttcta
     5161 atttcatttg gtttaaagca gcttttgctt ctggaactac tgttctgttt gaatttgaca
     5221 tagtaaattt cctcctcaaa taattagttt atgatgtcta acaacacttt tatttatgtg
     5281 atgttaatac taatttctcc aaaataaaaa taatatatac agaaaaataa aggtaaaaat
     5341 gtaaaaaata taaaaaaatt aaataaatga gtattttaga gagtttaatt aggtcaatat
     5401 aggttttatt tttttagtta ttgtcttata aattaaatat tacagtactt ttttgagctg
     5461 aaaaaaaata aattttaaat atagaagaaa ttatttcaaa gggggaatag tatgaaaaga
     5521 gaagttaaaa ggactaaagc tttgatatat agtgttttat ttttttcatt attattagtg
     5581 ttaatatttg tttttgttta tggaataaaa tacatatgtt ctaaatctga caattcaaaa
     5641 atgcctatat ataaagttga tacaaatgag aaaaaaatag ctttgagttt tgatgtagca
     5701 tggggaactg ataatatgga tgatatttta aaaattttag ataaacataa tgtaaaagcg
     5761 accttctttt tagttggtag ttgggtggat gataatgaag aaattgtaaa agctatagat
     5821 gaaaaaggac atgaaattgg aaatcattca aatactcatg ccaatttaaa ggaaatatca
     5881 aaagaagaca taacaaaaga gatagaaact acatcagaaa aaatatataa tataacagga
     5941 aaaaggacta atttatttag acctcctttt ggggacgtaa acaataaagc tatggacatt
     6001 tgtagtgatt taggttataa agtaattaag tgggatgtag attctataga ctggaaggag
     6061 cttggaccaa atcatgtaat tgaaaaagta ataaaagaat ctcaacctgg ttcaatagtt
     6121 ttattccatg ctaatataaa tgatgtagat aattatttgg atactataat aagtcgacta
     6181 aaaaaagatg gatacagtct agtcaaaata tctgatttgt tgtataaaga taattatgta
     6241 gttgattcca atggagtgca aaaaactaag aattaataag taataaatgt atattttaag
     6301 taaagttgtg ataaattata tagtatatgt tagaaaagtg tcgataaaaa gacggtgtct
     6361 attttttgac actttttata catgtatgca atatcaataa ttatagatta aattgattaa
     6421 aaaagtgtct aataattgac ttttttttga tgggtttaaa aatttagaag aattaatgaa
     6481 tgctgtaaga cagtatttcc aaagggtata agtttgttta aaagttggca tagaaattgc
     6541 tttgttaata agcgatatgt tctatagaaa taaacaatat gttaagacct tataatagaa
     6601 aaatagcatt aacattattt gaacagctta taaaaaaatt aatatactta agggggcgta
     6661 ctagttgaac aaactatatt ctattttatt aaaacaacac gttggtggtc cagataagcc
     6721 agtagtaagt gttggagatg tagtaaaaaa aggaactcta atcgcagaac caactggatt
     6781 aggggcaaat atttatgcca gtgttagtgg aaaaataagt gaaataaatg accaagcgat
     6841 agtaattgaa gctgatgaag tacaagaaga tacttttgaa ccattaaaag gagaaggtat
     6901 acttgactta attaaagaag ctggagtagt aggaatgggt ggagcaggat tccctactca
     6961 tgtaaaatta aacatagatt taaatggtgg aacaatatta gcaaatgcag ctgaatgtga
     7021 acctttatta gctcataata taaaagaaat agaagaaaga ccagaaatag tttatcaagg
     7081 tataaaatat gctatggaag ttactaatgc tggaaaaggt atgctagcaa taaaaagtaa
     7141 gcatccaaaa gcaatagaag ctttcaaaaa agtaataaag ccaggagaca acatagaagt
     7201 tgcagaacta gttgatatgt acccaatggg agaagagaga gcaatagtaa gagatgttct
     7261 aggaaaatta cttgagccaa ctcaattacc ttcagaggct aatgcagtag taataaacgt
     7321 agaaacacta actagaatag tagaggctgt tgagcaaaaa agaccagtta tatctaaaaa
     7381 tataactgta gttggtcaat taaacagtgg aaaagaatct atagtgtttg aagatgtgcc
     7441 aattggaaca actgtcggag aattaattga aagagctggt ggaataaaag gtgaatatgg
     7501 tgaaataatc ctaggaggac ctttcactgg taaagctact actttagatg ctccaataac
     7561 taaaactagt ggtggtataa tagttactat gccatttgtt aatgaaaaga gaaaaatggg
     7621 tcttttagtt tgtgcatgtg gacctaatga agaaagaatg agagatatag caactaaaat
     7681 gggagttact gatatagtat cagttcaaaa atgtaaacaa gctcaagaaa ttaaaggtgc
     7741 attaaaatgt gaaaatccag gacactgtcc aggacaagct caaaaatgta ttgaatttaa
     7801 gaaagctgga gcagaagtta tattaatagg aaactgtact gactgtagta acacagtaat
     7861 gggttctgca ccaaaattaa aattaggtgt atatcatatt actgaccatg taatgagaac
     7921 agttaatcac ccattaataa gaagaataaa aggtgacgta agattaaaaa taaaataata
     7981 gataaataga agttagacat ctttagaagt aaaacttaaa agttacttct aaggatgttt
     8041 tttaatgtat tttgagggca atatatatat tgtaaaataa atggaaaaaa tagacaaaat
     8101 atgctagata ttgtataatg ataacaatag ctattacaat taatattgga caaaaataat
     8161 gatactcaag tatgtggttt gtattaatat gcatattata ttaagtcaac tatccgatag
     8221 agtaaaaggt ttttgtgata tttgaagata ctctatagta tcttttttat tataaaaact
     8281 aatttttgtc ttttattaga taagtatcta ggatactaat ttatatttta ttgagttgtt
     8341 aaaaaagtgc acttaaaaag ttaaaaaaga aaaattaaaa acctatttat agaaactgtg
     8401 aagtatatct taaacctggg cacttaaaag atatatggag ttagtagtgc aacctgctat
     8461 aaatataaat aggagtaact tttaattgtc aaaaatatat aaaataaata cataaataag
     8521 taattaatag aagatagata taaatatatt tttgaaatgc tccctgcatt cataacgagt
     8581 gtagagtggc agatatctgc ccaaaactcc tttaattgct ggaagttcct aaagctaact
     8641 aaaccacaac ataatcatga aataaggata agtgtgatag agtgtgcatt taataagcac
     8701 ttgaggttac gaaagtagaa aaaattagtt agatagcata aggttaaatc ctaagtgcct
     8761 tgaaaatgga taatcagcag gtaagcttcg aaaagaagaa acttcaacga ctagagagaa
     8821 atctcgtacc tacaagtgtg gggaaatggg gagtacctaa tttatggtta ggtaatgata
     8881 tagtctgtgc ttaatagaaa tattaagaag ttcataggag aactggttag gagtaacgac
     8941 cctaattgaa cacactaaag atgtattatt gaataagatt catataatat ttaataattt
     9001 taattatatt aagtgaatac aatatatgtt tttagtatca ggagaatttt gaaaacaaaa
     9061 attaaaaaat caagtataat cagtttagta attgctttta gtatggtatt tactgcattt
     9121 acaccaatag tatcttatgc tgacgaagtg actagcaatg atacaatact taatggagaa
     9181 gaacaatcaa atggtcagac atcagatgta gagaaaccat cagacggtca ggtaccagat
     9241 ggggagaaac catcagacag tcaagtacca gatgtagaga aaccatcaga cggtcaggta
     9301 ccagatgggg agaaaccatc agacagtcaa gtaccagatg gggagaaacc atcagacggt
     9361 caggtaccag atggggagaa accatcagat ggtcagatac cagatgggga gaaaccatca
     9421 gatggtcaga taccagatgg agagaaacca tcagatggtc agataccaga tggggagaaa
     9481 ccatcagatg gtcagatgcc agatggagag aagacatcag atagtcagac gccagatgta
     9541 gagaaaccat cagatggtca gatgccagat ggggagaaac cattagatga gcaaactcca
     9601 gaagaagaaa aaccattgga agaagaaata gttatagagg aaatgagttt aaaacaagat
     9661 attgataaaa ttcttgatat gactttatct caaataaata aaatagtata taacttttgg
     9721 gaagatgaag aagatgtaaa ggcagatgaa caatcagaaa ttaaccaagt ttttacttca
     9781 gaagactcat ttattagctt atggtatgac aaaaaagcaa aagtaaaaaa ttcttgttta
     9841 ctaaaagaaa tagatggttc agatagacct tatcatgatt taagatttga tgatattaca
     9901 aagactttaa cttttgacta tgtaataaag ggtcttgtag gagcaagctc aaaagacgac
     9961 aaatatgtaa tagaaggtga agatggagag caaactgcat tttgttacaa taatcattta
    10021 agaccaccaa gtagtaatgg aaagagtcca tatttaccag cagaagattt taatggtcaa
    10081 gaaaaccaaa atgaagaagc agttaaatct atactatatg caggttctga atttgatgga
    10141 tttggatata agcaacaatt taatttaggt ggagaagaaa atgaattgat gacttactca
    10201 gctactcaaa gtgcaatttg gattattctt ggacaaatgg atgaacaaga aagacttaag
    10261 cagtatcaag gttctataaa cctttgtgat aaacttatag aaagagcaaa aactgaagag
    10321 gaaagagctg agtatcagaa gaagaaagaa gtagcgataa atataaaagc ttatttagaa
    10381 gcattgttaa aagcaggtcg tgaagagtta aagccaaata atacaggaaa acctagtttg
    10441 agtaatggtt taactaagat taactttgaa aaaaatgaag atggtactta tgaaacagaa
    10501 gctgtagcct tagtaggtta tagtggtgta gtaaagttaa aactaccaga tggagtaact
    10561 gcttatgatg gagatggtaa tataataggt acaggcgaag tagaaatttc aacgcaacag
    10621 aaatttaaac ttaagagtgt tggaaaacca gatgccaaag ctaatatttc tgctgtatct
    10681 tatgattata tttttccaaa agctattcaa tattataagg cagtgcttga tttaggacaa
    10741 aaagaccatt catcttcatt accatctagc aagcaaaatt tattaagtta tacaatagag
    10801 aaaaagaatg gtcaagaagt taactttaat ataggtttac caacagatga tgatgatgtt
    10861 gtaaatccac cagtgccacc aatagatgat gatgttgtaa atccaccggt gccaccaaca
    10921 gatgatacaa atggacataa gccaaaacca tcaccaccaa tagatgatac agtaataaat
    10981 ccaccagtac caccaatgga tgatacaata ataaatccac cagtaccacc aacggaggat
    11041 gcagtgttaa atccaccagt gccaccaatg gaggatgcag tgctaaatcc accagtgcca
    11101 ccaacagagg atacagtgtt aaatccacca gtaccatcag taagtgatac agtggaaaaa
    11161 actccagaac tatcaagaga tgatacaata ataaaatcac caaaaacagg tgatgaaact
    11221 cagctaatgt catatgtatt tattagtgtc attgcaattt gtggattagc gtatcaatgt
    11281 aaaataaaaa gaaattaatc tagattatta ttaagtttaa aataaaaagt ctcaaattga
    11341 tttataagtc attttggggc ttttttatgt aaatataata tgcaaatata gtttgtttaa
    11401 aaatatctat tttaattata ttcttaaatt tattattgga tacaggcatt cattaattgt
    11461 ttgatgaata gaaaaatgtt ttgaaggtga aaatagtatt gaaaaaataa tatactaagg
    11521 gtataattca tttgatttca tttgtataaa tttaattata aattttaaag tgattatata
    11581 aatttaaatg ctaattactt aataaatttt aataataatt atttaataaa taattattat
    11641 aatatgctag aataaatata tataaataag ttttgatgag gtactactat aaagggggga
    11701 ctttatgttt tcgataccag aagtaaaaaa agtagaagag gtaatggata caaaatttac
    11761 aactatagac gaagacacaa gaattgaaga tgcaataaaa gaaatgataa aaagcaacac
    11821 aaaaactcta atggtaatag attcatctga ccaattaaaa ggcattatat ccatgacgga
    11881 tatacataat ctttatgaga tgcataaaaa gtatgaaggt caaccagtaa aacttataat
    11941 gaagaaggat gtaatatatg tcaacgaagg tttaacctta gatgaatgta gagatataat
    12001 gatattaaaa aatataggga ttcttcctgt tcttagagat aataaaatta ttggagttct
    12061 aaaacaagag cacattaggg actatctata tatgcattta gaagattatg gattaacttt
    12121 gaagtatatt ataggtcaaa ttaaagaagg aatttgtgct ataaataacg aaggtgttgt
    12181 tatcttgtgg aataagttta tggaggaaag gtatgatata aagtctgaag atatagttgg
    12241 tcgaccgatg aatgaatttt tggaaaatac tatttcagaa aaagtactaa atagtaaagt
    12301 tggaatgagt gacttgtatt ttacagataa aaaagaaaat atgtatgcat tagttcatgc
    12361 aaatcctata ttttataaag aagaatttat cggtgttgta tgtacagaag ttgatgttac
    12421 agaagctaag atattagctc ttgaacttga aaaagtaaat gatacattaa aatatctaaa
    12481 gaacgaagtc aaaaatttat ctaaaggtag ttttgataag attttaggta aaagttataa
    12541 attggaaaaa tcgaaagcga ttgcaaaaca agtggctaga acaaatagta gtatatttat
    12601 ttggggcgaa agtggtacag gtaaagaagt atttgcaaga gctattcatg attatagtga
    12661 gagaaaaggg caatttatac ctgttaactg tagtgccata ccaaatgagt tatttgaaag
    12721 tgagtttttt gggtatgaat caggtgcatt tacaggagca agtaaaaagg gtcgaatagg
    12781 tatatttgaa cttgcaaaag atggaactgt atttttagat gaaattgccg atttacctct
    12841 tagtatgcaa gcaaagttgc ttagagtatt acaggaaaaa gaaataagaa gagttggtgg
    12901 agataccaca ataaaaataa atcctagaat aatatcagct accaataaag atttgagtaa
    12961 aatggtaaag gcagaaaaat ttagagaaga tttatactat agattaaatg ttgttgaaat
    13021 aaagattcct ccacttagag agagaaaaga agacatagga ttattggttc atagcttttt
    13081 agaggagata tgtaaacaaa ataataagcc tgttcttaca attagcaaag atgtaataga
    13141 tatatttcag aattatagat ggaaaggtaa tattagagaa ttaaaaaata cgattgaaaa
    13201 tattgttgta ttgtcacaaa attctaaaat agatgtggat gatgtaccaa gttatatgat
    13261 ggattctaca aataatagta ctgaagaaga agagtatcct ttagatttaa cgaaggcaac
    13321 tcaaaaaatt gaaataaaga atataaccaa ggcacttaaa atgtctaatg gaaataaagc
    13381 taaagcagct aagatattaa atatacccag aacaactttg tattataaga tagaccaata
    13441 caaaatagat gtgtctaaaa tatgacacat gactaaattt tgacaaaatg ataaacttta
    13501 atttaaaacc tagtaaagcc aacacttgta taagtgttgt gtatatagat gtgttaaaaa
    13561 aaatgaaaaa gtgttgatta attgacactt tttttgtttg agaaaatgtt tacaaataca
    13621 aaaaataaca tattttaaat aaatatttat ataatatttg gctaaaaata gcgatagatg
    13681 aagaatctat tatagaaaaa atctttttgt taataagttg gcataggaat tgcttataat
    13741 ataaagtgac tttaagtgag aaaaaaataa tattaatcat aacaaattat gtaggtttta
    13801 atttacttaa tttctcagtt aaggggttac ctgttgagga attgagattt aaaataataa
    13861 ataagaaaat aatgtaagga ggtattttat actatgtcaa taactttaga aacagctcaa
    13921 gcccatgcaa atgacccagc agtttgttgt tgtagatttg aagcgggaac aattatagcg
    13981 ccagaaaact tagaagatcc agcaatattt gcagacttag aggattctgg attattaaca
    14041 ataccagaaa atggattaac tataggtcaa gtactaggag ctaagttaaa agaaacttta
    14101 gatgcacttt ctccaatgac tacagataac gtagaaggat acaaagcagg agaggctaaa
    14161 gaagaagtag tagaagaaac agtagaagaa gcagctccag tatcagaagc agcagtagtt
    14221 ccagtaagca caggagttgc aggtgaaaca gttaaaatac acataggtga aggtaagaac
    14281 ataagcttag agataccttt atcagtagct ggtcaagcag gagttgctgc tccagtagca
    14341 aacgttgctg ctccagtggc aagtgcagca gcagaagtag ctccaaaagt tgaagaaaag
    14401 aaacttttaa gaagcttaac taaaaaacac tttaaaatag ataaagttga atttgctgat
    14461 gaaactaaaa tagaaggaac tactttatac atcagaaacg cagaagaaat atgtaaagaa
    14521 gctaatgaaa ctcaagagtt agttgtagat atgaagttag aaataataac tcctgataaa
    14581 tatgaaactt acagtgaagc tgtattagat atacaaccaa tcgctactaa agaagaaggc
    14641 gaattaggtt caggtataac tagagttata gatggagctg taatggtatt aactggtaca
    14701 gatgaagatg gagttcaaat aggtgaattt ggttcttcag aaggtgagtt aaatactact
    14761 ataatgtggg gtagaccagg tgctgctgac aaaggtgaaa tattcatcaa aggtcaagta
    14821 acaataaaag caggaactaa catggaaaga ccaggacctt tagctgctca ccgtgcattt
    14881 gactatgtaa ctcaagaaat aagagaagca ttaaagaaag ttgacaactc tttagtagtt
    14941 gatgaagaag taatagagca atacagaaga gaaggtaaaa agaaagttgt tgttataaaa
    15001 gaaataatgg gacaaggtgc aatgcatgat aacctaatat taccagttga gccagttggt
    15061 acattaggag ctcaaccaaa cgttgactta ggaaacatgc cagttgtatt atctccactt
    15121 gaagtattag atggtggtat ccatgcatta acttgtatag gacctgcatc aaaagaaatg
    15181 tcaagacatt actggagaga gccattagta ataagagcta tggaagacga agaaatagat
    15241 ttagtaggtg ttgtatttgt tggttctcca caagtaaatg ctgagaaatt ctatgtatct
    15301 aagagattag gtatgttagt tgaagctatg gaagttgatg gagctgtagt aactactgaa
    15361 ggtttcggaa acaaccatat agatttcgca tctcacatag agcaaatagg tatgagaggt
    15421 ataccagtag ttggtgtaag tttctcagct gttcaaggtg ctctagttgt tggtaataaa
    15481 tacatgactc acatggtaga caacaataag tctaagcaag gtatagagaa tgaaatatta
    15541 tctaacaaca ctttagctcc agaagatgct gttagaataa tggctatgct taaaaatgct
    15601 atagaaggtg tagaagttaa agctcctgaa agaaaatgga atccaaatgt taaattaaat
    15661 aacatagaag ctatagaaaa agttacagga gaaaaaatag tattagaaga gaatgagcaa
    15721 tctctaccaa tgagtaagaa gagaagagaa atatacgaaa aagacgaaaa ctaaaattta
    15781 gatactaact aagatttaga caataacata aatttagatc caagtttaaa acagtataga
    15841 gaggtagaat tataatggat aggttaaaat atatctcatc agagactttt tatgaaggta
    15901 ttatagttga catcaaaggc ggtggagtga ctatagacct aaaaggtaga cttggacaat
    15961 ttaaaatacc taatagaatg cttataactg actacgaact taagataggt caagaagttg
    16021 gattcatgct aagctatcct gaggtattaa gtccagagcc taatcaagag tatgtagaaa
    16081 atattaggag agaaaaagaa aaacaagcag aaatgcaatc aaaacaagaa gaaaaataat
    16141 aaataatcgt ttgaaaatag aagggagagg aaatatatga gccttacaac agtacaagga
    16201 cttcaatctg aaatattcgt tccaataaca cctcctccag tttggactcc tgtaactaaa
    16261 gaattaaaag atatgactat agctttagct acagcagctg gtgttcattt aaaatctgac
    16321 aagagattta atctagcagg agatactaca tttagagcta tacctaatac agctacagtt
    16381 gatgaaatga tggtatcaca tggtggatat gacaatggag atgtaaacaa agatataaac
    16441 tgtatgttcc ctatagatag attacatgaa ttagctgcag aaggatttat caaaggagta
    16501 gctcctatgc actatgcatt catgggtggt ggaggaaacc aacatgtctt cactgaagaa
    16561 actggtcctg ctatcgctgc taaacttaag gaagagggag tagacggtgt agttatgaca
    16621 gctggctgag gtacttgcca tagaactgcc gtgatcgtgc agagagcaat agaggaagct
    16681 ggaataccta caataataat agcagctctt cctccagtag ttagacaaaa cggaactcct
    16741 agagcagttg ctccattagt tccaatgggt gctaatgctg gtgaaccaca taatatagaa
    16801 atgcaaacac atatattaag agatacatta gagcaattag ttgcaatacc atctgctggt
    16861 aagatagttc cattaccata cgaatataaa gctcacgttt aaaatgtaat ttatatttga
    16921 aaatatagaa cccttctcct acacggttag gagaggggtt ttaagaacaa aggtggatat
    16981 tatggaagaa aaaataatga gaagacttgt tataaaaccg tttcatatga atgaagttaa
    17041 tttcggttca aaaacttcta taaagaaaga tgtacttaca atagatttat caagtataga
    17101 tgaaataaaa gaaagagaag agttaataac agacataaaa gtagacatta taaaacctgg
    17161 agattatgac agagaaatta atactattat ggacattata ccaatatcaa caaaagtttt
    17221 aggcagactg ggagagggta ttacacatac tttaacgggt gtatatgtaa tgttaactgg
    17281 tgcagatgaa gatggaaatc aaatgcatga atttggttct tcagaaggaa ttttgaaaga
    17341 ccaaatggta tttgggagat atggaactcc atcagttgaa gattatataa tccatgtaga
    17401 tgtaacttta aagggaggtt taccttttga aagaacactt ccacttgcag cattcagagc
    17461 atgtgatgat tttatacaag aaataagagc gtctttgaaa atggaagacg gaagaaatgc
    17521 tactcaagtt cgtgaatatt ttgacaaaat tcgaccaaat gcaaaaaagg ttgtcatagt
    17581 aaaacaaata gcaggtcaag gtgctatgta tgacaatcag ttattctcaa aggaacctag
    17641 tggatttgaa ggaggaacat caattataga tatgggaaat gtacctatga ttatatctcc
    17701 taatgaatac agagatggtg cccttagagc tatgacttaa gagaggtgga tattatggga
    17761 ataggacctt caacaaaaga aacatctctt catcacttta gagacccact tttagacata
    17821 gttgaaagtg ataaggatgt agatttactt ggagtaatag tagtaggaac tccagatgga
    17881 aatgaaaata aaacctttgt gggacaaaga acggccgctt ggctggaagc catgagagta
    17941 gatggagcta tagtttcatc agatggttgg ggaaactcac atgttgacta cgctaacaca
    18001 tttgaggaaa taggaaaaag agatatacct gtagttggag ttacatttaa tgggactcaa
    18061 gctaagtttg ttgtaagcaa tcaatatatg gataccatag ttgatatgaa caaatcaaaa
    18121 gaaggtattg agacagaagt agttggagaa aacaacacaa atgaaataga tgctaaaaaa
    18181 gctttggcat ttttaaaact taaaatgaga aaacatggat aaaaaattta agtaagggaa
    18241 tgagttttgt gggaatttct acatcaatga aaaacacatc acttcatata tttagagacc
    18301 cgttactaga tttgatagat aatgattctg acatagactt gttaggagtg gttgtagttg
    18361 ggacatcaga gcacaatgaa tggaaaacat ttttagcaac tagacttgga agatggattg
    18421 aatcattgcg acctgatgga gtgattataa ctttagatat ggcaggaaac cagcacattg
    18481 attttacaaa tgctatagca gagtttgtaa aatcagatat acctacagta ggtcttacta
    18541 ttatgggagc agatggatta gtaattacca atccatagtt ggataaagct accataattg
    18601 attataaaaa gacaacaggc tacatagaaa cagaagtagt tggagacaat cacatggatg
    18661 aagttgatgt taaaaaagca ttggctttcc taaaattaaa aatgcgtaaa gacgcaaaat
    18721 aaacctaagg gggaatttga tatgaaattt agcagaagta tacaagctat agactctcat
    18781 acagcaggtg aagcaactag aatagttgta ggtggaatac ctaacataaa aggaaattct
    18841 atgcctgaga aaaaagaata tttagaggaa aatctagatt atttaagaac tgctataatg
    18901 ttagagccaa gaggacataa tgatatgttt ggttctgtaa tgactcaacc ttgttgccca
    18961 gatgctgact ttggaataat cttcatggat ggtggcggat accttaacat gtgtggccat
    19021 ggtacaatag gagctatgac agcagctata gaaacaggtg tagttccagc agtagagcct
    19081 gtaactcatg tagttatgga agctccagca ggaataataa gaggagacgt tacagttgta
    19141 gatggaaaag ctaaagaagt atcattctta aacgtaccag ctttcttata taaagaaggt
    19201 gttgaagttg acttaccagg tgttggaact gttaaatttg acatatcatt tggtggaagc
    19261 ttctttgcta taatacatgc aagtcaatta ggtttaaaaa tcgaacctca aaatgctggt
    19321 aaattaactg aactagctat gaaacttaga gatataataa atgagaaaat agaaatacaa
    19381 catccaactt tagctcatat aaaaactgta gacttagttg aaatatatga tgagccaact
    19441 catccagaag ctacttacaa aaatgtagtt atatttggtc aaggtcaagt tgacagatct
    19501 ccatgtggaa ctggaacaag tgctaaatta gctactttac atgctaaagg tgaattaaaa
    19561 gtaggagaaa aattcgtata tgaaagtata ttaggaactt tattcaaagg tgaaatagtt
    19621 gaagaaacta aagttgcaga tttcaatgct gtagtaccta aaataactgg ttctgcttat
    19681 ataactggat ttaatcattt tgtaatagat gaagaagacc cacttaaaca tggatttatt
    19741 cttaaataag taataaataa attaggaaat taaaatagaa tagtagccac ttgtcggttg
    19801 ctattctata gcttttaggc tataagattc agaatatatg aaaaaataaa aaaataggag
    19861 gatggattat ggtagcaatc ttaaaggcat tatatgtagt attcgcagca atctttgcag
    19921 ttgtgtttgg taaagacgta gctaaagcaa acaaagaggg gaaactagaa gaacaaagta
    19981 ctccaaaagt tgctgtaaca ggatttataa cagacttctt tgatacatta ggaatagggt
    20041 catttgctcc aacaatagca atgtcaaagg ctttaaagtt aaatatacca gataaaaaaa
    20101 tgcctggtac attaaacgta gcacatacta ttccagttgt tacagaagca ttcatattta
    20161 catcaatcat accagttgat ggtgttactt tagtatctat ggttgtggca gcagcagttg
    20221 gttcatatat aggtgcagga ataatagcta agatggacga gagaaaaata caacttgtta
    20281 tgggtgtaac tttagcatta acagcaatat taatgttatt aggtcatcct tggattaacg
    20341 tattaccagg tggaggaaat gaattaggtc ttactggtgt taaattagta ataggtgtaa
    20401 taggtaactt tatactagga gctttaatga cagctggtat aggtttatat gctccaggta
    20461 tggcaatggt ttatttctta ggaatgtctg caaaagttgc attcccaata gttatgggtt
    20521 cttgtgcatt attaatgcca gttgcaagta tgaaattcat aaaagaagat gcatatacta
    20581 aaaaagcatc agttataata gctatatgtg gtttaatagg agttttcgta gctgcatata
    20641 tagtaaaaac tctaccaatg gatatattaa aagcattagt aatagtagtt atagcttata
    20701 cttctgctac aatgataatg gctgcaaata aaaacaaaaa gactgcttag ttaaagacta
    20761 cttagtgttt attaaatatt acagctaata ataaagatta taaactgctt taaaatattg
    20821 aattaatatt ttagggcagt tttttattta ctaaattaat ataaagcaat taacatgcca
    20881 attatgtaat atatatagtg atttagtaga tttaatgtaa aaaacgttgt atttttaaag
    20941 aataaagcat aatttaaagc taaatattta aattttataa tcaataagtt caataaatgt
    21001 tcatatatta atacagatta ataaaaatat aacctataat aagtctaata taacttataa
    21061 ttaagaaaaa taagtttata atgactcaat attcatctga attatttgaa taaatttaat
    21121 tcgttgaagt tgcttatata gagtgaataa atttaagtta tatatgactt attaactata
    21181 taataggatt tttataatta atacaaaact gaaataggta gtttaattag tatatgtggt
    21241 acaaaaagat aataatttta taattataaa agtgaaatat taaatgaaat ttataactaa
    21301 ataaaaactt ttaaacagca atcaaagatt tgtaataaaa tacatccctt ataaatatat
    21361 ttattatata agctgatacc agaaatataa gaattaacaa ttgtggaggg ataaaatatg
    21421 atagctgtta aagatgagaa taacgtagta aacttaagag gggagttaga caataagcta
    21481 gaatttagcc atgagatatt tggagaaaaa ttttataata tgaaaataaa aataaacaga
    21541 ctaagcgatt cttttgatat acttccaatg actgtatcag aaagacttct ccaagatatt
    21601 gaccttgata aacaaaattt agtcaatgtc gtaggccaat taagatcata taacaaaaca
    21661 ttaaataata aaaatagatt agtgcttaca gtgtttgtca gagaaataaa aagcatagac
    21721 gaggaaaata aagaccctaa tagtatattt ttagatggat atgtatgtaa ggaacctgtg
    21781 tataggaaga cacctttagg aagggaaata accgatttat tagttgctat aaacagacct
    21841 tataataaat ctgattatat accatcaata gtttggggta gaaatgctaa atttgcaaag
    21901 aatctaaagg ttggtgatag aatacagctt tggggtaggg ttcaaagtag agaatatgag
    21961 aaaaaaatag atgaaaataa tgtggtcaaa aaaatggcat atgaagtatc catatcgaaa
    22021 ataaaaaaat tggatgaaaa taacaatgaa taaacataaa aaatagactg atttttatga
    22081 ataaaatcct aataaatttg gtataatatc atattaaaat gtataaagat tgtttaaaaa
    22141 aatactaatg aaatatctct tgaatagttg ctcgccattt attataatgt aatctgtaca
    22201 taatttataa ttgaggaaat gaagaggtga agcattgtga aaagcatatt atgtcagata
    22261 aataaacagc cggttaaagc taaatataca tctgatgaat tagaatgttt tttggataca
    22321 attgagtata atgtaggtga taaaatattg cttgttggtc atataggaaa cctaggcaag
    22381 agattgagag gtcttggaac ttctgtaact atactggaga atagtaatta tgaagatgtc
    22441 tgttattctc tagtgtataa tgaaaattgc aatgtagtta aaggtaagtt agagtttcta
    22501 ccatttgatg ataatcagtt caacaagata ataatagttg accaatttaa tgttattaca
    22561 gattgtgaaa aagcttcatc tgaaatacaa agagtgttaa agggcaatgg agaggttata
    22621 ttagaggatt taaatttaaa gaatttaaaa gttaagttaa actatcttaa acataaattt
    22681 tgtggttctg ttgcaaagat tcactatcca catgaagtat ttaatatatt ttcaagatta
    22741 aactttgatg gtatgattaa agagtcaaat aaattaaaat atatttatgt gggaaaaaga
    22801 agataaatga gttaaaatat aaatatggat ataatataaa agactaggtt aagcctagtc
    22861 ttttgttata aggagatgtt tagatggaaa taaattatga gttaataata attgttatgc
    22921 tctttgtaat cctgatgtca atccaattta ctttaaataa gatatacttg attcttaaag
    22981 aaataagaca aatacttatg ttaaagaaaa ataaggaatg atgattatga taggtttaga
    23041 atatataaaa tctgatattc aaaatatagc tgaagctata gtatcagtac tcaatataga
    23101 tgtaactata gtaaataagg agttatttag gattgcaggt acaggagtat atatagacaa
    23161 aataggtgag aaagtagata aatatacggc ttttaaaaaa tcacttacag agcagattac
    23221 aatactaatt gatgacccaa agagtagtga tatatgtagg gaatgctata aaagtggggc
    23281 ttgtgtagag tttgcagagg tgtgttgtcc cattatatgt gatggagtct ctcatggtgt
    23341 tataggcctt atagccttta caaaggaaca agcacagatt atagaaaata ataaaagtgg
    23401 tcttataaac tttttaggca aaatggcaga cttaatatct aataaattaa aagctcaaat
    23461 taaaacttat gagcttgaat tagaaaagaa aaaattagag acactgttaa acaatatgga
    23521 caaagctgtt gtgtctattg atgtggatgg aaaaattgat aaatataatt caaaatttaa
    23581 agagcttttc aatataaagg atagtataac tggcaaaaac atatttgtcg aattagattt
    23641 tataaagaaa ccttctataa ataactttaa gaaagacaaa tcctgtagtt ttttttataa
    23701 aagatacgga tatgattcga agggaatata caacatcaat aaaatagtat taaaaaatga
    23761 gttaaaggga tatgttattg attttataga taaaagagat gctataaaaa actacaataa
    23821 gatgaataaa gattatagaa taaaattgga aaacataatt ggagaaagtg tagctataag
    23881 aaattctaaa aaggaagccc taatagcttc taaatcaaca tcaacagtac ttattactgg
    23941 ggaaagtgga acgggtaagg agctatttgc aagagccata cacaaccata gcaatagagt
    24001 agataatcct tttatagctg taaactgtgc tgctatacca gacaatttat tagaaagtga
    24061 attatttgga tatgaagagg gagcttttac tggagctaaa aaaggtggaa agcttggaat
    24121 gtttgaagta gctcataagg gaagtatatt tttagatgaa ataggagata tgagtttgca
    24181 tttacagtca aagttattga gagtattaca agaaaaggaa cttaataaaa ttggaagtaa
    24241 atcaaatgtt tcaatagatg taagaattat tgctgctaca aataaagatt tagaaaaaat
    24301 ggttcaaaat ggcactttta gagaagattt atactataga ttaaatgtta tacctataaa
    24361 attaccaagt ttaagagaga gaaaagaaga tatcccactt ataatcaagc atatggttaa
    24421 agagtattca aaaaaattag ataaaaatgt tattgacata gatagcaggg ttgttgatgc
    24481 tatgatggaa tataagtggc cagggaatat aagagagttg cagaatatta ttgaatatag
    24541 tgtgaatatg tcttcttctt caataattac aatgaatgta attcctcaaa aaattaagaa
    24601 tacctctgta gaagagttag aagttaaaag cgataggata attccacttg atgaactaga
    24661 gaagattgag ataataaaag ctttaaataa gtacaaagat tataaaaaag ataaagaatt
    24721 aacagctaaa gcacttggaa tatcaagagc tacattatat agaaaaattg aaaaatacaa
    24781 tataatttca tagtaatata ataaaaagct atataaaatt taaatttttc taaattcata
    24841 actttaaaga aagctttaaa cttatactat aagtgttttg cagaatcttt ttttatgaat
    24901 taaaaaatgg tttttataag ttaaaaaata atatatttga gccgtctcaa aatgatatag
    24961 aatctcattt tgagactttt ttttgtcttt ttgcgaaatt gtcatatgtt tctccatttt
    25021 aaagaatata aatactctat acaaataaaa aaaatacata aatagaggca gtcataccaa
    25081 tggttataga atataagact aaaaatataa aaagatataa aaaatatggc atgtattttg
    25141 ctataaatat agataagaaa ttatttaatt aattatttga gtactaaatc taaacttaat
    25201 tgggaggttt atatataatg agagatataa gaaaagaatt agtggaaatg ttaaaggcag
    25261 aagttaaacc agcagtaggg tgtactgaac cagtagcctt agctctagca tgtgcaaagg
    25321 caaaggaatt attaggagaa gaaatagttg aaaatcgtat gttagttagt cctagtattt
    25381 ataaaaatgg tatgtgcgta ggtataccag gtactgaaag attaggatta aaaattgcag
    25441 cagctctagg tatagtaggt ggacattctg aaaatggatt aagtgtgtta gaaactctaa
    25501 caaaagagga agttaaaata gctgaggatt atatggataa tactccacta tcaataacac
    25561 ctgctgatac aagagagaaa gtatttatag aagttgtgtt aaaaggaaaa aatcatattg
    25621 ctaaagtgag aataagaact aaacatgata attttacgtt cttagaaaaa gatggagaag
    25681 tattattaga caatgaacca aaagtatcag cttcaaatga tgcggcagaa aaagctgaaa
    25741 gtttaatgga tacagtaact atacaagaat taataaaaaa tgtagaagga attgatttta
    25801 aagatataga atttttacta gatggagtaa aaatgaatga agagatggct gaatatggat
    25861 taaaacaaaa aactggtatt ggtgtaggat atggaattaa aaagtctata gaagaaggtc
    25921 ttttaggtaa tgatgttata aattatgcaa tgatgttaac tgctggagct tcagatgcaa
    25981 gaatggcagg ggtaaaaatg cctgttatga gttcaaatgg aagtggaaat catggattaa
    26041 cagcaattct tccaatcgtt gcttataata aaaaattccc acaatctgat gaaagactag
    26101 caaaagcttt agctatatct catctagtaa ctggttatat taagaactat acaggaagat
    26161 tatctgctgt atgtggatgt ggtgttgctg cttctactgg agcaactgct ggtatctctt
    26221 ggcttatgaa tggtactgaa aagcaaatag aaggagctat agaaaatatg atagctgact
    26281 taagtggaat gatatgtgac ggtgcgaaag ctggttgtgc attaaaatta tcttctgcag
    26341 catctgcagc tatacaaagt gctataatag ctaagcaaga ttgttttgta ccaccactaa
    26401 atggtatagt tggttcaagt gttgagcaaa gtatacaaaa cttaggtaga gtaagtgaca
    26461 aaggtatgtc tataacagat gagataatct taaatgtaat gaatgatatg aataaagttg
    26521 actagtactt tataatatgt tttgtattat gaggtataac aaaaatagca taaataaatt
    26581 taattagtac cctctaataa aatatgatta tgtataaatt tatgtataat agaaaaaact
    26641 tgttaatgca agttttttct ttttttgtct aaaatatata gtatgtaatt tagtgtggat
    26701 atatgaacta cttaaaatat aagatacatt gttaataatt gttgaatgaa cataaaaact
    26761 caataatatt gactaatatt gaataagagt attgaaaaag tgagcaatct cttataaaat
    26821 taagaaggat tattacaatt ggaggtcttt ttatggatat agaaacaaaa aaatgggaag
    26881 tattgtattc agaagaaaaa attaaagata aattaaggga attaggagca attatagaaa
    26941 aagattataa agataaaaat cttatggtag tttctctatt aaaaggtagc tttatatttt
    27001 gtgcagactt agttagaaat ataaacttac cacttagagt taattttatg actacatcta
    27061 gttatggaaa caatgaagaa agtactggaa aggttaaagt agtttcagat gtgactactg
    27121 atatagcagg atatgatgtt ttggttgtag acgatattac tgattctgca cttactatgg
    27181 attttgtgtt aaaacatcta aaagctaaaa atcctgctag tttaaaatgc tgtgttcttt
    27241 tggataaacc aagcagaaga aaagtcgatt tagtgccaga ttattgtgga tttgaaatag
    27301 aagataagtt tgtggttgga tatgggtttg attttggtga ttattataga aatgttcctt
    27361 atatattcaa tgttactgat gaagatagat aagcaattat ataattttgt ggatgcctta
    27421 atatgatttt tattaatcgt gttgaggttt ttttatttaa aaagtaatta aagtagtatt
    27481 aaattaattt tatgcaattt aattatctat tttttatagc ataataaaaa aattttaaat
    27541 aattgatggg aaatgagttt tttaattgta ttaataattg taaaagagta ctaataattg
    27601 taaaagattt tacaaaaaag taatgaaatt taagaatcaa agcatatatg ttgatataag
    27661 caaatagata cattatcaca taagaaattg tcgattcata taattatata gagtaatact
    27721 caatatttat agagtattac tctaacttta aaaaaggagg attaattata tgagtgatat
    27781 ttcaggtcca agtttatatc aagatgtagg tccaacaggg ccaacaggtg ctactggtcc
    27841 aacaggaccg acggggccta gaggtgtaac tggagcgacc ggagcaaatg gaataacagg
    27901 accaacagga aatacaggag caactggagc gaatggaata acgggtccaa caggaaatat
    27961 gggagcgact ggaccaaatg gaacaacagg ttctacagga ccaacaggaa atacaggagc
    28021 gactggagcg aatggaataa caggtccgac agggaataca ggagcaaccg gagcaaatgg
    28081 aataacagga ccaacaggaa acaaaggagc aaccggagca aatggaataa caggttctac
    28141 aggaccaaca ggaaatacag gagcgactgg agcaaatgga ataacaggtc caacagggaa
    28201 tacaggagca acaggagcaa caggaccaac cggactaact ggagcaacag gagcaaccgg
    28261 agcaaatgga ataacaggac caacaggaaa tacaggagca accggagcaa atggagtaac
    28321 aggtgctaca ggcccaacag gaaatacagg agcaacaggt ccaacaggaa gtataggagc
    28381 gactggagca acaggaacaa ctggggcaac aggcccaata ggagcaacag gagcaacagg
    28441 agcagatgga gaggtaggtc caacaggagc agtaggagca acaggtccag atggtttggt
    28501 aggtccaaca ggcccaacag gcccaaccgg agcaaccgga gcaaatggtt tggtaggccc
    28561 aacaggccca accggagcaa ccggagcaaa tggtttggta ggcccaacag gcccaaccgg
    28621 agcaaccgga gcaaatggtt tggtaggtcc aacaggagcg acaggagcaa caggagtagc
    28681 tggggcaata ggtccaacgg gagcagtagg agcaacaggc ccaacgggag cagatggagc
    28741 agtaggtcca acaggagcga caggagcaac aggggcaaat ggagcaacag gcccaacggg
    28801 agcagtagga gcaacgggag cgaatggagt agcaggtcca ataggtccaa caggtccaac
    28861 gggagaaaat ggagtagcag gagcaacagg agcgacagga gcaacagggg caaatggagc
    28921 aacaggccca acaggagcag taggagcaac gggagcaaat ggagtagcag gagcgatagg
    28981 accaacaggc ccaaccggag caaatggagc gacaggagca acaggggcga caggagcaac
    29041 cggagcaaat ggagcaacag gtccaaccgg agcgacagga gcaacaggag tgttagcagc
    29101 aaacaatgca caatttacag tgtcctcttc aagtttagtg aataatacat tagtgacatt
    29161 taattcatca tttataaatg gaactaatat aacttttcca acaagtagta ctataaatct
    29221 tgcagttgga gggatataca atgtatcttt cggtatacgt gccacacttt cacttgcagg
    29281 atttatgtca attactacta actttaatgg agtaactcaa aataacttta ttgcaaaagc
    29341 agtaaataca cttacttcat cagatgtaag tgtaagttta agctttttag ttgatgctag
    29401 agcagcagct gttactttaa gttttacatt tggttcaggc acgacaggta cttctgcagc
    29461 tggatatgta tcagtttata gaatacaata gtttatatga tgaaaagatt ataaaataat
    29521 aaacaatatg atttcatata ccaataaata gaataatatt taataggttt atatgatgaa
    29581 aagactataa aataataaac aatatgattt catataccaa taaataggat aatatttaat
    29641 aggtttatat gatgaaaaga ctataaaata ataaacaata tgatttcata taccaataaa
    29701 ttaggataat atttaatagg tttatatgat gaaaagatta taaaataata aacaatatga
    29761 ttctatatac caataaatag gataatattt aataggttta tatgatgaaa agactataaa
    29821 ataataaaca atatgattcc atataccaat aaataggata atatttaata ggtttatatg
    29881 atgaaaagac tataaaataa taaacaatat gatttcatat accaataaat aagataatat
    29941 ttaagaaaaa tgattatatt taaaaggtaa gcataaaatt tataaacttt tagaatagaa
    30001 atctcaatca attagatatt caaattgatg aatatgaata cctaaataga ttgagattta
    30061 ttatgtacaa aacttatcct aatatatctg acattttata aagcccagat tgcttaccaa
    30121 ttaaaaattt agctgcaact atagagccgt ttgcaaatac ttcatcagat tgagaatgat
    30181 ggcttaatgt aagaacttca ttatcacctg caaatacaac atcatggtcg ctgattatat
    30241 tgccacctct tatagagtgt attccaattt catttggttt tcttttacaa tctctaccat
    30301 atctaccatg tgtattttca ctttcaggca agacttctct aattgcatta gctatcatag
    30361 tagcagttcc actaggggcg tcttcttttc tattgtgatg tttttctatg atttcaatat
    30421 caaaaccttc taacatcttt gaagcatcct taactaattt tattaatata tttactccaa
    30481 gagatgtatt tgatgataat aatataggaa tgttttttga tgcttcttct attttattta
    30541 agtcattttc gtcatatcca gtagtagcta atactacagg tgtattattt tttagagcat
    30601 atgacaatat tggctctaaa gtatcatgat gtgaaaagtc tataattaca tcagtttttt
    30661 cagttacatc agtcattgtt ttgtaaagct ttgtatcact atgatgacct ttttcatcag
    30721 cagacctagc tacaccacaa accaactcta attcattatc tttttttaca cattctgcta
    30781 aaactcttcc cattgttcca ttatagccac taattataac tttcaacata aattcctcct
    30841 atgaaattaa taaaaatttg ttatatttct ataagtttat tttatcacta atataattta
    30901 tataaaataa tattagtgat aataagctta caatttatct tacattaaaa aatttaagtg
    30961 gatttttcaa aatatagata aatttctttt tcattgttta aatgataaaa atatatttga
    31021 cttcatacca aaaagagtgc cccatgaact aaaaagttaa ttttgaaata ccatattcat
    31081 atatcatatg atttatttgg aaattaatat taatacatta aaataactaa atacatgtat
    31141 gcataaagat gtataaaaaa tatataaaca tatagtatta attttaaatt caacaattta
    31201 attgttaaaa gtgttattat taaattagaa atatcttaac ttaatatact gagatgggag
    31261 tgatagatat gttaaaagaa gaaaaaactt atcaagagaa agacgcaaaa gtattcaatg
    31321 gagtggcagc tttgataatg attttattat ttttagtagt ttcaataggt atcatggttt
    31381 ttgggatagt aaaacttgat agtggattta ctggaatagg ttcacttatg ttaattttgg
    31441 gacttgtatt tatagtagta gattttatcc tattttttgg gctaaaaatg attaatccta
    31501 aagaagctat agttctagtt ttgtttggta actattatgg aactataaaa aaagaagggt
    31561 actattgggt gaatccattt tgttcagcaa taaacccagc agtatcaaga attaatgtat
    31621 cgaaatcttc atctgatgaa aaggtagata tatcaactaa ttcaaggggc aaaaaagtat
    31681 ctttaaaaac aatgactctt aataatgaaa agcagaaagt caatgattta ttgggaaatc
    31741 caattataat aggagtggtt gtaatttgga aggttataga tgcaacaaag gcagtattta
    31801 atgtggataa ttataataca ttcttatcta ttcagtgtga ttctactatt cgcaatgttt
    31861 caagacttta tccatatgat gtatctgaag atggagatga aaaatctctt cgtggtagta
    31921 gtcaggaaat agcagataga ttaaaagatg aattacaatc aagggttgac attgcaggaa
    31981 ttgaagtgtg tgaagtgaga attactcatc tttcttatgc accagagatt gcagcagcaa
    32041 tgttacaacg tcaacaagca gaggctataa tagcagcacg taaaaagatt gttgaggggg
    32101 ctgtaagtat ggtagagatg gcattgacta atttaagtga aaataatgtt gtgactttgg
    32161 acgaagaacg taaagcagct atggtaagta atctgttagt tgtgctttgt ggcaataaag
    32221 atgcacaacc agtggtaaac agcagttcta tttattaaat tataaaaagt ttaatagttt
    32281 attttattga tatatagaaa atttagtagt tcattttatt aaattatata aagattaatg
    32341 gtttgcttta ttgaattata aaaagtttaa taatttattc tattgatata tagaaaattt
    32401 agtagttcat tttattaaat tatataaaga ttaatggttt tcactttatt aaattataaa
    32461 aagtttaata gtttattaca ttgatatatt gaaaaattga aggaaataaa aatacttgtc
    32521 agcaagaaat aaaaatgata taagaatgaa taagagaatt gtaaaaaaat aaaatgatta
    32581 taaataaaag ataaaaatat tgtaaaaaag agggtgcctc tggtgaatta aattcacaca
    32641 gagacacctt tttaattaat tttttaaatt agtatattat tgtttaatta atagcatagt
    32701 actatttaat taatctaaat ttctaaggtc ttccataagc ttagttttgt cagccgtttt
    32761 ttcatctttc atttttataa ctttagcagg agaaccagca acaacggcac cagcttctac
    32821 atcagtagtt acaacagcac cagctgcaac aacagcacct ttaccgattc taacaccttc
    32881 aagaataact gcattagctc ctattaaaac atcatcttca actataacag gagtagcaga
    32941 aggtggctct aaaacaccag caacaacagc accagcacct aagtgaacat ttttaccaag
    33001 agttcctcta gctccaataa cagcattcat atctaccata gaaccttcac caataacagc
    33061 tcctatattt ataacagctc ccatcattac aacagcattt ttttctatag taaccatgtc
    33121 tcttattatt gcacctggct caattcttgc atgttcactt aaagtatttt ttagaggaat
    33181 agcagaattt cttctatcat attctacatg agtatctgtt atatcatttc catgtttatc
    33241 taatacttcc attatatcct catagtcacc tacaaatata taagaaccat tacttccaaa
    33301 taccttaaat ttatcagttg attggaagtg taaagagtta gtatttacat ataccttaac
    33361 aggtgttttc tttttaactt cttttatata ccttgctatt tcataagcat cgtttaaatt
    33421 taccatttgt taattctcct tgtatttcat tatatttctt ttattatata cttatttgtc
    33481 aattttagta tatacttact tcttattatt tatattttat tttagttagc ttttattgta
    33541 tagacatagt attaaataaa tttattatat atgtttgatt tgtattgcat attattatat
    33601 atatattgta tatgtttaat ttatattgtg tattattata tttatactat tatcccaaca
    33661 tgctgtccat attataaaat cctggttttt gcttaactaa gtatttggca gcagctatag
    33721 aaccacttgc aaagatacca cgagattgag cttgatggct tattgtaaga acctcattgt
    33781 ctccagcaaa tagagcatca tgttcgccaa caatatttcc acctcttata gcatgaatac
    33841 caacttcatt tggttgtctt tttgcactac gaccatatct accataatta ttttcaacgt
    33901 ttggcaaaac ctcttttata gcgttagcaa tcataacagc tgtgccactt ggggcatcta
    33961 cttttctgtt gtgatgtttt tctattattt ctatatcaaa tccttctagt aatttagctg
    34021 catctttaac caattttact aatacattta caccaagaga catattatat gattggaata
    34081 caggaataac tttagccgct tcacgtattt tgttcatttc gtcatcatta tatccagtag
    34141 tagcaattac taaaggtgtt ttagtcttta aaacgtaaga taagatatta tctaaattag
    34201 agtgatgaga aaaatctata actacatcag cttcctcaac tatagtactc atatcttcat
    34261 aaattttaag gtcgccttca tagctatcca gacctctagc tgcaacacaa accaattcta
    34321 attcattatc ttctcttata gtatcggcta aaatcttacc catttttcca tcataaccag
    34381 ttgctataac ttttaacata atttcctcct atgattaagg gctaactttt gaccaaactt
    34441 actttttacc atgcattaat ctttactatg cattaacttt tagtccaaag ttaactaatt
    34501 ctttctttaa tacttctaaa tttgctgggt ccatttctgc tagaggtaat cttaaatctc
    34561 caacattgaa tcccaataaa ttcattgcag tcttaactgg tataggattt acttctataa
    34621 ataaagctgc gattagagca tccataccaa gttgtaattt tctagaacct tcaatatcgc
    34681 cttcaaagaa tttagctacc aaatcgtgag tttcttgagg gcaaacatta gcaagtactg
    34741 atataactcc ttgacctcct aaagataata aaggaagtat agtatcatca ttaccagagt
    34801 agatagcaaa gtcatctgga actaaactag ctatttctgc aacctgtcct aggtctccac
    34861 tagcttcttt tacagcaact atgttatcaa ttttagcaag ttcaactata aggctaggac
    34921 ttatatttac acaagttctt ccagggacat tgtaaagtat aattggaagt ttaacactgt
    34981 tagctattgt ttcaaaatga cgcttaagtc cagctttatt agctttattg taataaggtg
    35041 ttattattaa tagagcatct actcctaatt tttcagcttc ttgacttaag ttaactgagt
    35101 gcatagtatc attagaacca cttccagcta taacaggaac tcttttatta actttttcaa
    35161 caacatactt aatagtagca agttgttctt catcagtcat agtattagct tcaccagtag
    35221 taccacaaga tactatagca tcagtaccat tagctatttg gtattcaact aattcaccta
    35281 atttgtcaaa atcaactttg ttatcctttg taaatggtgt aactagagca acagcagaac
    35341 ctttaaatat catataaaat caatcccctc ttttttattt ttgtgtttta tattacagtt
    35401 acttctaatg cttgtttttg agttactatt aatattttac aaaattatat atttatacaa
    35461 gtttgtatat tatactaaat cgtatgataa agccatttca gctatttgaa ttgcgttagt
    35521 tgcagcacct tttcttatat tatcagcaac aacccaaaga tttacaccat tatcaacact
    35581 aaaatctctt cttattcttc caacaaatac ttcatctcta tcatcaaatt ctacagcagt
    35641 tggatattcg tttttagcag gattatcaac tactacaaca cctggagctt cttcaagtgt
    35701 ttttactaaa tcatctaact caaatggatt gttaaactca acatttatag attcactatg
    35761 accatttttt actggaactc ttacagtagt tgcagttatt tttaaatcgt agttatcaag
    35821 tattttcata gtttcattta ccattttcat ttcttcttta gtgtatccat tttcagtgaa
    35881 tgaatctata tgaggaagac agttgtaaga gatttgatga gggtagaatc cagtaggatt
    35941 accgttcatt cctttctcta aatcttcaac acctttaaca ccagaaccag atacagcttg
    36001 gtaagtagag taaacaactc tcttaatttt gtatttatca tcaagagctt taaggggaac
    36061 catagcttgt atagtagagc agttaggatt agctattata cccttatgat tttttatggc
    36121 ttctggatta acctcaggaa ctactaaagg cacatctgga ttcattctcc attgactaga
    36181 gttatctact actaagattc catttgaagc agctattgga gcatactttt cactaatact
    36241 tccaccagca gagaataatg ctatttgtat gcctctatca gtaaatgaag tttcctttaa
    36301 ttcttctact atatattctt taccacaaaa cattacttta gaaccagctg atttagaaga
    36361 agagaataaa aatagatttt ctattggaaa atttctttct tctaatactt ttaaaaatgt
    36421 tctacctacc attccagtag caccaattat tgctacattt acttttttca tataaattca
    36481 ccccaatttt aaattattaa aacattattt tattttagtt atacaagtaa gatatgttaa
    36541 tatttttata tatccaaaaa ctttaatatt atattaacaa ctttaattat atacaaaaaa
    36601 cgtacaaagg tatactttgt acgtctaatt tatcactcaa agtaaaccct gtagctcatc
    36661 acctacaaaa ataagtgaca gtattacaca tgttatgtgc aatcccagaa aatattattg
    36721 caagaaatat tttcttcggc tgtaaatcct ttttccaatc attaacacct gccagctact
    36781 attggatact cttagttaca gctacctcta ccctaggtta ataggatatt aaaatttgat
    36841 tattctaata ataatacata tttaagaaaa aatcaactta tttatataaa tattgctaaa
    36901 atttaaatcc aaaatttgtc aattcttgtt ttaacacatt aagattagtt tcttccattt
    36961 cagctagagg aagtcttaaa tcaccaacat taaaacctaa aatgttcatg gcagttttaa
    37021 caggaactgg atttacttct ataaataaag cagcaattaa agcatccata tcaagttgta
    37081 atttttttga gccttcaata tcaccttcaa agaatttagt tactaaatca tgtgtttctt
    37141 taggacatat gttagcaagt acagagataa taccacttcc acctaatgat aatagtggta
    37201 gtatagtatc atcattaccg gagtatatag caaagtcttt aggtactaat ttagctattt
    37261 ctgcaacttg agctaagtct ccacttgctt ccttcacagc aactatatta tctattttag
    37321 caagttcagc cacaacagat ggctttatat tcactttagt tcttcctggt acgttgtata
    37381 aaataattgg caacttaacg ctatttgcta ttgtttcaaa gtgaagttta agacctttct
    37441 cattagtctt attatagtaa ggagttatta ttaaaagacc atccacccct aatttttcag
    37501 cttcttgact catatgaaca gacaacatag tattgtttga accagtacct gctataacag
    37561 gtattctctt attaactttt tcaactgtat attttattac agcaaaaatt tcagattcac
    37621 tcatagtagt cgcctcacct gttgttccac aaacaactag tgcatctgtg ccattctcaa
    37681 tgtgatattc gattaattca cctaattttt caaagttgac attattatcc tctgtaaatg
    37741 gggtaactaa agcaacagca gaacctttaa ataacatata atcaaatctc cttttttatc
    37801 taaatttaat tttttaagta caataataat tatagtacaa attaattaat tttaataggt
    37861 atagttaata tcttaactgt ttaaataaga tatttatatt atattaatat tagaaaaatt
    37921 ttaaataaat gttttattct caaaatatgc atattaattt aataaaatat accaaaatgg
    37981 aaataaaaaa taaattttat gagaatttaa taactaataa ttaatatatt taggttataa
    38041 taaatatgtg cgtaaaatct aacaataagc aataataccg taaatttagg aggaataata
    38101 tggatacttt aaaggaactt tttaaaatag gaagtggacc ttcaagttct catactatgg
    38161 gaccacaaag agcagcagag agatttaaga atgaaaaccc agatgcagaa agttttagag
    38221 caatattata tggtagtttg gcagctacag ggaaaggtca cttaactgac tatataattg
    38281 aaaaaactat agcacctaaa aaagtcgaaa ttgtttggga agaagatatt ataaaagatt
    38341 ttcacccaaa tgggatgaag tttgaagctt tagataaaga taaaaatgta acagctgaat
    38401 ggactgtata ttctgtaggt ggaggaacta tagcagaaga aggtcaaaga aacagtaaaa
    38461 gcaatagtat atatcactta gatactatgg atgagatagt aaaatggtgc aaagaaaata
    38521 ataagacttt ggtagatttt gtgttggaat gtgaaccaaa agacataaaa gattatataa
    38581 aaactataaa agatgctatg agaaaatcta ttgatgatgg actaagtaca gatgaaataa
    38641 taccaggcaa gttattatta aaaagaagag caagtacatt ttataatgca tataaaaaag
    38701 ataagagctt ctcaacactt gtatatgcat atgcactagc agcttcagag caaaacgctt
    38761 ctggtaatat aatagttaca gcaccaactt gtggttctgc tggagtaata ccaggaatat
    38821 tctttgcaat gcaggatttc tataattatg atgacgaaaa aataattgaa gcactacttg
    38881 tagctggaat aataggtaat ataataaaaa ctaacgcttc aatatctgga gcagaggtag
    38941 ggtgtcaagg tgaagttgga gccgcttgtt ctatggcagc agcagcagta gcatacttaa
    39001 aaggtggaac tatagaccat attgaatatg cggcagaaat agcacttgaa catcatttag
    39061 gaatgacttg tgaccctgta tatggatatg ttcaaattcc atgtatagaa agaaatgcaa
    39121 tggcagctca aagagcttat gatgcagcta attatgcatt attaactgat ggctcacatt
    39181 ctgtctcctt agaccaagtt gttgaaacaa tgaaagaaac tggtatagat atgatggata
    39241 agtacaaaga aacagctaag ggtggacttg ctaaacattt cttctcttgc taaaaataaa
    39301 attttccaat aataattcct ctgttttgat ttatgaaaca ggggaattat tattaatggt
    39361 gaattattta ataatgcaaa atatttttat attcaattta gctttttatt tttaattagt
    39421 ataacatgct atataatatt ttaattataa agaaatatag aaatattttt taataaatta
    39481 gaaattggag gagattacat gagagaggca tcatatttac aagaacaact ttataaacat
    39541 aggaagtcat taaatcctat tgcagagatt gggagaaaag agtataagac ttcaaaatat
    39601 ataagagatt atcttgataa attaggaatt gagtatgaag tttatttaga aacaggtata
    39661 gtaggtgtaa tagaaggtaa aagacctaaa aaagatattg cttttagagc tgacatagat
    39721 ggtcttcata gtgaagaagg ggtaaaacat ttatgtggtc atgatggaca tgctactatc
    39781 ttacttggat taattgagta tttaaatgat aataaagaag acttaaatga taatatagta
    39841 tttatattcc aaccggcaga agaaggtcct gggggagcaa aagctttaat agatgaagga
    39901 gtgcttagaa aatacaatat tgatgaaata tatgggcttc atatatatcc agagttacca
    39961 gaaggttatg taggtacaag agagggctat tttatggctc aaataggaga tattgacata
    40021 gaaatagtgt ctaaaagtgg acatggggct atgccacaaa atggtattga tggtatagtg
    40081 atagcttcaa actttgtaag ctcacttcaa actatagtgt ctagaaatat aagcccaata
    40141 gacaatgcag tgttgactat tggcagaatt gaagggggag ctagaagaaa tataatagct
    40201 gaaaatataa agatggaagg tactatgaga tgtttcagcc cagaagtgta tgagaaaatg
    40261 aagcttagag ttagagaact tgctagaggg tttgaattgg cttataactg taaggttaat
    40321 ataaatatta tagatgatta tatcgctgtt aaaaatgaca aggatttgta tcaagagttt
    40381 gtagaggcta ttggaagtga tactgttgta gagttagagc cacttatgat atcagaagat
    40441 ttttcttatt atcaaaaaga agttccagga ttatttttta tgttgggttc aagaaacgaa
    40501 gaaaaaggat ttgtaaatgg tcttcataat ataaacttta attttgatga aaagatatgt
    40561 gtaaatgcat tgaatgttta ttcaaaatta ttaaaataca aagaagcaat agattaggaa
    40621 gataagttat aaagattaaa aagcataaat acctaaattt aaaaaaagtg tattaataaa
    40681 taccccttac atatttgtat aaatttattt taattgacaa aaatacaaat aagaaggggt
    40741 gatttttttg aaagaaaaag tacaaagaga aaagaagata actaatggca agaatactaa
    40801 aatattgaca aatgatgata taatgaaata tgagatagcc tcagaactag gtcttatgga
    40861 taaagttggt gaacgtggat gggcaggact tacagctaag gaagcaggaa gaattggagg
    40921 tatgcttaca tcacgcaaaa agaggcttaa aaagattgtg gaggagcaga ataaaaagga
    40981 tgagtcaata tagtgatttt gcgtttgtat atgatgaact tatgaatgaa gttgattata
    41041 atggttgggt taaatatata gaagatataa tagatagtga aggtgtaaaa gtaaaaaata
    41101 tattggaatt ggcatgtggc acgggtaatc ttacaattcc attgactaaa aaaaattacg
    41161 atatagctgg tatagatata tctgatgaga tgcttagtgt agcaagagaa aagtcagaaa
    41221 aagaaggagt agaattagtt ttacttcaac aagatatatc agagcttgat tttgaaatat
    41281 ctgatttgga ctgtgtactt tgtgcttgtg atggattcaa ttatataact tatgatgatg
    41341 atttggaaaa tgtattttca aagacatatg aattattaaa gaaagatgga atattcatat
    41401 ttgatataag ttctttttat aaattagcca acatattggg aaataacatg tatggagaaa
    41461 atagagaaga tatagcgtat atgtggcaaa attactttga tgaagaagag aatctaattg
    41521 aaatggaact tacattcttt attaaagatg aatgtggaaa atttgaaaga tttgaagaga
    41581 tacaccaaca aagagcatat actgaagatg agatagttga tatgcttgaa aaatctggat
    41641 ttaaggatat aaaatattat ggggatttta catttgacaa acctagtgaa gaaagtcaaa
    41701 gaatcttctt tgtatgtaaa aaataagata tttttgacta tataagataa ttattaaaaa
    41761 taaccatgat ataaaaatat agaaaatgca gttttataga ttaaaagtaa agtgatgata
    41821 ctttatgact tttatttttt aataattata aagttctata gataaaaatt aaaatataat
    41881 aactattgct tagtaaaatt aaaataaaat gggttttgcc caaggttaag atagataagt
    41941 atttatagat taaaattaag gtagtaatat aataaaaata agacaattaa cgggacatgg
    42001 aggaatatta atgagagatt atgtactaag agcgacatca ggaaatggtc aagttagagc
    42061 atttgtcgca actactagaa atacagtaga agaagctaga agattacatg aaactacaaa
    42121 agtagcaaca gcagcacttg gaagaacatt aacagccaca tctataatgg gattaatgat
    42181 gaaaaatgat agtgataaat tgactgtaat aataaaaggt ggaggtccaa ttggaactat
    42241 tatcgccaca tcagactcta agggaatggt aaaaggatat gtaggaaatc cacaagtaga
    42301 ggttgaagac tatccaaatg gaaagttaaa tgtagcagca gcagtaggta cagaaggtgt
    42361 tgtaaaagtt ataaaagact taggtcttag agaaccatat aatgggactt atccattggt
    42421 aagtggagaa attgcagaag actttactta ttattttgct gtatcagagc agactccatc
    42481 agtagtagct ttaggtgttc ttacaaaaga agatgaagta gagtttgctg gaggatttat
    42541 agttcaatta atgccagatg cagaagaaga gactattgct aagttagagg aaaatgtagc
    42601 taaattacct tctataacta acatgttaaa agaaggaaaa tcaccagagg atatattaaa
    42661 tattgttttg gatggtttgg aacctaaaat acttgatacc tgtgaagttg ggtttatgtg
    42721 tgaatgttca aaagaaagag taaaaactgc tttggttgca attggtaaaa aatcattggc
    42781 tcaaataata gaagaagata aaaaagcaga agttggttgc cagttctgta ataagaaata
    42841 tatgtatagt gaagaagagt tgcttgaaat tttaaaggaa atgtagacta taaaaatagt
    42901 tgtattgata taagtaatgt tatagtgata tagtaaagtc gtattgatat agtaattaaa
    42961 gtataattta ttaataatag acatatttat attaaaaaat aagtttaata aatttttaag
    43021 cttaataaat tttaagaatt aagaagcttt ctggctgtaa tgtttgcaat gttgcagtta
    43081 gaaggctttt ttattttatt atagttcgtg tcaaagattg tatgaaacaa taaaatattg
    43141 taaaataatt tgtatattta gacctgattg gcacaaaggt ttataaggta tttgagttga
    43201 ttatgcgaaa ttctatgaag tagtaaccct gtgactttaa tcatgggagg ttcagaagaa
    43261 ggagaaaatt ttaaatatgg aaagtaaaac gaagtacata ggaataagta tattaatatt
    43321 attgatgata tttttaattg caaaaaattt taacggaaaa cttgaaatac ctattcctga
    43381 gagtaatagt agaaaattta aatcagcagc agtgttttat cctcaacatc aagatgatga
    43441 ggttttatgg ggaggaagtg ccattgtaga tgctataaaa cagtgtggtg ttgataatgt
    43501 atatgtggta ttagtatcag atggttctgg agttaacgtt ttcaaagcta acacaaaatt
    43561 tagaaattta actaggaagc aaaaggaaga acttagaaat aacgagttta aatcagcttt
    43621 gagagagctt ggagtgaaac ctcaaaatgt gattatactt gcagatatag ataaaaagga
    43681 aggcacacat tatgaattaa tggaaaagac tatattggat tttgaacata agtttaaagg
    43741 caatgtgacc catatagccc atcactataa gtatgatgac catataatgc atagaaagaa
    43801 tggggaagtt ttaaagaaac ttaaacgtga aggtaagata aaagatgact tgtattttgt
    43861 taagccaaaa tatgtaaagt atataccaag aaatgaaaga gctatctata aagcaatgga
    43921 ttttgatgac tacaataagg ttaagagtgc ttgttatgaa tataaggttg taaattcaaa
    43981 gcgtaaaatg tatggtatag gatatatttc ggcacatagt tattttgaac atcttctaaa
    44041 tgaccctgaa cttacgtctg tattaagtga agattaattt cttataagta gtaagttatg
    44101 tttgataagt tgattggaat tttctatagt tttgaaggta ttggaaattt agttttattt
    44161 aaagatttaa agatagaggt ttttagtgtt taaaatttta aagttaagtt gaataattgt
    44221 atagaattat ttgtgaaaga agaaacagtg taaaacatag tatcttattt atggttttaa
    44281 aatcataggc aagatacttt ttttatgtaa ctaataccat tttgagatta ttaacttaag
    44341 aattttatat aatttaacac tcatatataa tgatgatatt taggtagaat agatgcaatt
    44401 acgcttaaat aaaataactg tattttttat aaaaatcaaa ccctacacta tactaccaga
    44461 taaaatctac atgctataat ttgacctgtg tttataaaaa aaggagtaat ctaataaaat
    44521 agtatttcac ttatgtataa ctaacaacta ttattacgat tttctctaaa taatttaaag
    44581 aaaaataatg caggaggtaa aatatgaaca atgaatttat aattttaaaa ggttgcaaag
    44641 agaacaattt gaacaatatt tccttaaaaa taccaaaaag aaaaataacc atattcacag
    44701 gggtgtcggg ttctggaaag tcatctattg tatttgagac aattgcaaaa gaatcacaac
    44761 gccaactaaa tgaaaggttt agtacatttg taagaagttt tttacctaag tatggagagg
    44821 ttaaagctga ttgtatagaa aatttgtcaa caccaattat catagaccaa agtagacttg
    44881 gtggaaattc aaggtcaacc ctaggtacta ttacagatgt aaattccttt ttaagagctt
    44941 tatattcaag gtttggtagt gagtatatag gtaatgctaa tatgttttct tttaataata
    45001 ttgatggtat gtgcccacac tgtcatgggc ttggaaaaaa gctagttcct aatatgaacc
    45061 aaattcttga tatgaataaa tcattaaatg aaggtgctat attgctttca gggtttggag
    45121 tgggttcttg gcattggaat atattcgctg aatcaggatt ttttgatatt aataagagga
    45181 tatgtgatta ttcagaagta gaattggaaa agtttttgca tggtaaagca gaaaagatta
    45241 agatagaaaa tgctggtcaa actaacatga catatgaggg attaatggtt aaatttaatc
    45301 gcctatactt aagtagagag ggagaaatat ctgaagctac taagaaaaaa ttgagtaaac
    45361 ttcttataga agatagatgt cctatatgtg atggaagaag acttaatgaa agagtatata
    45421 ggtctttaat taatggttat aatatagcag atttaactag tatgcaaatt gatgaattgg
    45481 ctgaagttat taaaagtata gatgagccag aagcacaacc tttaattaaa ggaataatag
    45541 aaaagttaaa cagtatcata gatataggtc ttggatattt aacactggat agagagacat
    45601 cttctctatc aggaggggaa tctcagcgta taaagatggt taagtattta aatagtaatc
    45661 ttgttgattt aatgtatatt tttgatgaac caagtgtagg acttcatcca aaagatgtgt
    45721 ataaattaaa taatctttta aaaaaattgc gtgataaagg gaatacaatt atagttgttg
    45781 aacatgaccc agatgttatt aagattgcag accatattgt agatgtagga ccaaaggcag
    45841 gtaagtatgg tggagaagtt gtgtatgaag gcagttatga aaatctactt acaagtggta
    45901 ctttgacagg gaatgcttta agtaaatttc ttcctattaa agaaagtgta agagaacata
    45961 gtggatattt agaagttaaa aattgtaata aaaacaattt aaaaaatgta tcgattaaga
    46021 tacctaaagg tgtattgact ctagttactg gagtagcagg agcaggtaaa agtacgttga
    46081 ttaaggatga atttttaaag caaaatccta gtgctgtact tatagaccaa agccctgttt
    46141 cagcaaattc aaggtcgagt ttggcaacat atagtggaat tatgaacaac ataagaagca
    46201 tattttcaaa aacaaatggc gtaaatgctt ctttattcag ttcaaattca gaaggagctt
    46261 gtgataactg taagggttct ggaatagtag aaatgaatct tgcttttatg gagagtataa
    46321 agagtacctg caatgtttgt gaaggtaaaa aatttaaaaa agaagtttta gaatataggt
    46381 ttcaagggaa gaatataatt gaagttcttg aaatgtctgt tttagaggca attgagtttt
    46441 ttaatttaaa acagattaaa acgaaattac aatgtattga aaaaatgggt attggatacc
    46501 ttactttagg acaaactctt gatactttgt ctggaggaga gtgtcaaaga ttaaagcttg
    46561 ctagtgaatt aaataaggaa agttcagtgt atatattaga tgaaccaaca acaggtcttc
    46621 atatggctga tattgagaat tttataagta taattgaaga gattgtagat aatggaaata
    46681 cggtcataat aattgaacac aatatagatg taattaaaag agctgattgg attattgagc
    46741 tgggacctga aggaggaaca aaaggcggga gagtaatatt tgaaggtatt ccaaaacaat
    46801 tatgtaacaa taaaatatca ttaacagcaa aatatatagt ataataaata aaatataata
    46861 aaattataat gatattttaa taaatataat gggtatataa aatgataatt aaacttaaca
    46921 gtaataaata atgtgagaaa tattcaaatt taattaaata aagtgtcaga aatttgttta
    46981 aattttagta ttttaacggt tctgaccttt tttcttattt ttatggagaa tatcgaggat
    47041 ggagtctcta atagttactt ttttgtgtct acttgcaagt ttgattaaaa aatggctata
    47101 cacacttgtg acttcagtca tgggaggttc agattataat cttaatatat aatttgtgaa
    47161 ataatttgat gacgatttgc tgatgtataa acaataaaga ttaactacat taaaatttaa
    47221 atcttgttaa gtaaaactta taaaaggaga gagatggatg ataaatgata ttctaacctt
    47281 attatctgaa agaagtgatt tttttataaa gctatccata gaacatttga tgatttctat
    47341 tatttctata ataattgcga ttgttttggg tggtataatt ggtattattg taagtgaatt
    47401 tcataattct tctaaaccta tattgggaac tatcaatttt ctatacacca ttccatctat
    47461 ttctatgcta ggatttctga taccattttc cggaattgga aatactactg ctgttattgc
    47521 acttaccatt tatgcattat tgccaatggt tagaaataca tatactggaa ttactaatgt
    47581 ggataaaaat attcttgaag cagctagggg aatgggaagt acagattttc agatattgta
    47641 taaaataaaa cttccgttag ccctacctgt tattatgtct ggtattagaa atatggtgat
    47701 tatgacaatt gcattagctg gtatcgcttc atttataggt gctggaggtc taggtgtagc
    47761 catatataga ggaatcacga caaataacac aataatgaca attactggaa gtatacttat
    47821 tgctctatta gctttaatat ttgattttat tttagggctg gtagaaaaat tttttcaacg
    47881 aaaaagaaaa aagaaaaata ggaaaaaagt ttttgccatt ctaggaagcc ttattcttat
    47941 agcaactatc tttacgtctt atttatttaa tccttcaaag actcaaacta ttcatattgc
    48001 tactaaacct atgactgaac aatatattct tggtgagatg ttggatattt taattgaaaa
    48061 aaacacaggt ctaaacgtgg aaattacaca aggtgtagga gggggaacat ctaatatcca
    48121 gccagctatg gagaatggag aatttgacat ttatccagag tatacaggta caggctggaa
    48181 tatggtactt aagaaaaatg aattatatac tgaaagtatg tttagtaaac tacagtcgga
    48241 atacaaaact aaacttaaaa tgcaatggac tggtatgtat ggtttttcta atagctatgc
    48301 attagcagtt agaaaagaag ttgcagataa atacaattta aaaaatataa cggacttaaa
    48361 agatgtatct tctaaattga catttggagc tgaatatgac ttttatgaga gagaggatgg
    48421 atatactcca ttgtgtaata catatggact gaactttaaa gatacagttg atttagatat
    48481 tggattaaaa taccaagcta tcaatgaagg taagattgac gtaatgccta tatttacaac
    48541 tgatggtcag tatagtgttt cagatgttgt agttctaaaa gatgataaaa atttctaccc
    48601 atcttatcaa tgtggaaatg ttgttcgttt ggaagtatta gaggaaaatc cagaactatc
    48661 aaaggtattt aagatggttg gagatatttt gactgataaa gaaatggcta aaatgaatta
    48721 tgacgtagaa aacaacaatt tagaacctag agaagttgct cgtgagtttc tgaataagaa
    48781 aggtctttta taaattggag gaaatataat gacacctatt atacaattta aaaatattaa
    48841 aaaacaatat aatgataaaa ctataataga taatcttaat ttagatatag aaaaaggaga
    48901 gtttttgact gtaattggtt cgtctggttc tggtaagaca acactcttaa aaatgattaa
    48961 tggtctgatt ttgccagatg gaggaaatat tttgataaac caaacagata tcaaaaacga
    49021 ggacttaatt aaattaagaa gaagaatagg atattgtgta cagggaagtg ttctttttcc
    49081 tcatatgact gttgaagaaa atatttcata tgtaccaaat ctcctaagta aaaagaataa
    49141 attagaagta aaaagtgctg taaacaagtg gatggaaata gtgggattgc caaatgatat
    49201 gaaagtgcgt tacccatcag aattgtcagg tggtcagcaa caacgtgtag ggattgcaag
    49261 agctttagct tcttctccag aaattttatt aatggatgaa ccttttggtg cagttgatga
    49321 gattacacga aagcaattac aaaaagagat aaaagaaatt cataaaaaaa caggagttac
    49381 aattatcttt attacgcatg atatttatga agctttgatt ttgggaacaa agactttggt
    49441 attaaatcat ggagttgttc aacagtatga tactcctgag aatattttaa atactcctgc
    49501 taaccaattt gtagaccagt tattgaatat aagaaaatct ataatagatg atgataattt
    49561 aaaagaataa atttaaattt aaaatcaaat tgttgtgata aaaactattg atttagagct
    49621 aacttcaagt tgtatacttg aagtggaaaa gttagattaa ggtatagaag ggcatttagc
    49681 agttggctgt agacgaggta actgctgaag gtgctttcaa taaatggcta gaacctgtat
    49741 ctgttgaaga ttataataaa ttgaaataag aagctcaata tacagagtag ataggcactt
    49801 caaatagaag tgtcttttgt gtgccataaa ataaatcaaa atattagcaa agaatgtgaa
    49861 aaacaaaata aaataatatg ctatctttaa aataggaggg atgctatatg gataacaatt
    49921 tgattaccat tgaaaaaact ttagattata tagaaaaaca tcttttagat gagatgttag
    49981 atttaaatgt aatttctaaa gagataggct attcaaaata ccatttacat agaatgttta
    50041 catcagttgt cggatttagt gtacataatt atatacaaag acgtagactt actgaagcag
    50101 cgagaatgct aatttttaca gaaaaaccaa ttattgagat tgctttaatc tcggggtatg
    50161 atacacaacg ctctttttca agagggttta aaaaaatgtt taaacgtagt cctaattttt
    50221 ttagaagaca tcaagatttt ttaccactac aattaaaatt tgatattcat aatagaaaaa
    50281 aattacgtgg agatatggtt ttagatgtta aaaaagttaa ttgtgcagat ataaatattg
    50341 ttggctattc tggtaaagta agaaaaggat ttcatattat tggaaaatgc tggagggatt
    50401 tgcataaaaa taaagagatg atagaaaata aggtagattt aggtttttta attggagtta
    50461 gtgattatag caattttaaa gagattgaga atactcctac atttacatac attgcaggtg
    50521 ctcaagtagc tacttttggc aaattaccta atggaatgga aaaattcgta ttaccgaaaa
    50581 gtaattatat tgtttttact tttattggga aaaatgagga tagtatgcaa aatgttgtag
    50641 aatatatcta tcaagaatgg ttccctaatt caagttgcca gtttaatgaa aataatttat
    50701 atgactttgt aaaatatgga gaaaaaactg atgagaatgg tttgagtgaa attcagtttt
    50761 gggttccaat catttaaaag aaggtattat gtataaagta gatggattta tataggcaaa
    50821 gttttacagc agtatgtatt tataaataat ttatagtttg taggaaagaa ataattttac
    50881 tataagatta tgataaaata cacaatacta tgacaaaata gtgttaaata atagatttaa
    50941 ttttgcatag gaaaagttct ataatggtgt gtattcataa ataatttata atctgtagga
    51001 aagaaatagt tttactataa gattatgata aaatacacaa tactatgata aaatagtact
    51061 aaataataga tttaattttg caaaggataa ggtgttttaa taaaaatgaa tgtagaaaac
    51121 gaattactta aaaacctaga tagattgcat acaacagagt taggcgttgt aagaattaag
    51181 aaaaatcttt ctttggagac aaatgatgta gtgaactggt gtaaaactaa aatagaatct
    51241 ccaaatgcca ttattaatag aaagggaaaa aactggtata taagtgtata tgattgtatt
    51301 ataacagtaa acgctcacag ttatacaatt attacagctc ataaagaaaa gaaatgaatt
    51361 gcaaaataca aaggtcaaaa gcattttcca ctgtttgtag tacctatgaa gaagtatata
    51421 aaataatatt acttttgaat aataatttaa attttggagg ttgaaaaaat gaatgatact
    51481 gtaaaagaaa aattggcaga gtcactaact tctgatacta ctgatatttt accttatttg
    51541 ccttatttat tacaagattt ttgggaatta ggaagttcac cagaacaaat gttacaatta
    51601 tttagaaagc atataccttt taatgaggat acaaaagttt tggatttagc ttgtggaaaa
    51661 ggtgctgtat ctgtgaagct tgcaaaagag ttgaatatac atatcaaagg tattgatttg
    51721 atacctgaat ttattgatta tgctagaaga aaggctattg aatataaggt tgatgctttg
    51781 tgtgattttg aaatgaatga tgctaatagt tctgtaaaaa ttgagcatga ttatgattgt
    51841 gtgatttttg gagctgtagg ggatatttta ggtaattata aagaaactat aagtaagcta
    51901 ttacctacaa taaaaagtaa ggggttcatt ttaattgatg atgcatatgt agtagataaa
    51961 tctacaaatg aacagcttaa ttttgagagg gtgtatccca cttacaatga gtggtgtata
    52021 ttgttcaaag aattaggtct gaagctaatt gaatgtatac catgtttaga acttgaaaat
    52081 gatgttgaag aggaaatgaa ttggattata actcgtgcaa atgagctaat taaaaaatat
    52141 ccttctcaaa aagatatgtt tgaacaatat gttattagcc aaaaaaatga atatactgat
    52201 ttacagcagg accttgttgg agcaacttgg attttacaaa aagaataaga taaatattag
    52261 actagataat caatgttata gtgaattatc ccatgtctag tgaatataaa taacataaaa
    52321 aaccgtcaag atgaatagtt tattcgtgct tgacggtttt tagtatttgt tgaagtaaaa
    52381 ttttatttct ttagtatatc acttttagtc aatccatttg atttagcttg agtattccat
    52441 tgatgattcc ccataagttt atataggaat ctagggaagt taggtgaaat aaaaatagta
    52501 cttttgttgg aatcatctat atgtatatta tcactaagta tattttttga aagttctttt
    52561 aatgcaattc ctaaatcttt tttaggtcct ttacccaaag gtacggattc tagtgaacca
    52621 aacatctccc cagctccaat tccaatacct tgaacccatg taaagttgat ttttttacac
    52681 caatgctcta tcatttgaat tgccaaatga ttatgttcac cttcattgaa tccacagtta
    52741 actattgcat acactggaat aggtttttta ttttgtgttt ttaaaaattt ttcacatttc
    52801 tctaaaaaat gaagtaaatg agatggaata ccatctacat aaagaggaga tgcgattatt
    52861 aatctatcac aattaagtat ggcattaaga gcgtcaggat acttagatgt gttatctact
    52921 ttaaatgtaa aaactttatt atcattttga ataagttgtt ttaattcaga taaaaaatac
    52981 tgtgaattat ttttatttac ttttggacta ccatttatca ttactatatt catatggatt
    53041 cacctcttat atcttgtata ttttcataga aacaaacaga gtgttctttt atattgaaat
    53101 ttatagcatt tccatttact aatttcgtag cagtttcttt ttcagcttct gtaatacaat
    53161 ctccatagaa tatagctttt aaatttatct gtttatcata tctgctttta tgacgcatca
    53221 tattatcttt tattacaaag tatggaagaa tataattaat gcttttatca agtacgtttt
    53281 tgacaaaagg gctaaaccct ccgtaacagc atctgcttat tataataatt ccatcagagt
    53341 catttataag tttacccatg ttgctgtaat aatcttttac aacacattca gaaggagttt
    53401 taatccagca accaaaacaa ccaatacatt tgtggatttc ttttgtgttt ggaagtattt
    53461 ttatattgtc atcaagtttg ggtaataact tttctaattc tttgtcagtt aaatcatgta
    53521 ttaaaagcct cataaagtcc atctcctttt attatgtatg tttacttcta aaaattatat
    53581 cttatagatt tttcagtaaa tctttacacc aattaataac aaaattataa tagtcaactc
    53641 cataaatcat tgttgcatac atatatgtat attggtcaac acaatgattt tcttctgcat
    53701 catttttttg tttacttaat ttatttagaa gtaattctac ttcagttatt aacattttta
    53761 agtttgtttc aattatttct ttgggtagat acttgtaaaa gaatatatta acaaggtggt
    53821 cttgctttgt tttagaaaaa tttataggtt tctttaacca ttcaagaaat acttctttac
    53881 cagtattagt tatggaatat agttttttta atttgttacc atctataact tcgtgatagt
    53941 gtatatatcc ttttgtttct aatcttttaa gtgcaggata gatacttcca aagctggcgt
    54001 caaaaaagta cgaggtactt tctgacatta tttgttttaa gtcgtatcca cttaattctt
    54061 tttccattaa aaatcctaaa ataatgtatt ctaacatatt acctcctggt atcaattaga
    54121 tatatatcga ttcgatatat ttattattac agataataaa tcttacgtca agatgctttt
    54181 taagataagc taaaaagaat taggagttat tgataaatat gcaaaaaaat taatataaaa
    54241 ggtaattaaa tatcaataaa gatttaaaaa tagttaaatc aaagtaagag tctaatatat
    54301 aaaatttata gtaactttat ggtttaaata taaacttgtg tgctattgac aaagtataaa
    54361 attagcagta gaataattgc atgagcaaat agattgttgc gaacgcaaaa aaaggacaat
    54421 agatattaaa ggagagaata tgagagagct attaaaatgg gtttccatta taaatagata
    54481 caatacaaat tatattgaca ggaaattggc ggatattgga atcaataata gccaatattt
    54541 ttatgtatta cacatatgta ataatccagg tattacacag gacactatat ttgagaaaat
    54601 tcttgtgaat cctagtaata taacaagagc tttggcaaat ttagaaaaag aaggctttat
    54661 aacaagagaa ccaggtgtaa aggataaaag aacatggcat ttatatccta cagaaaaatc
    54721 tttaggatgt tatgatgaaa tactaaaaat aacaaatggg tatgttgagg agttgttgag
    54781 ttcatttgag aaagaagagc aagagttgtt tatgtcaatg ttaaagaaag ttgcattttt
    54841 ggctattgat atgaatgaag aagcaaaatt ggaggcgaag gaaaatggaa gaaaaatata
    54901 aggagccatt ggaatatgaa aaggtttcaa agttattaac taagtacgca attcctagta
    54961 ttatagcaat gttagtaagt gctttatata acattgttga ccaaatattt attgggcaag
    55021 gtgttggtgt attgggcaat gctgctacaa atgtcacttt tccactaaca acaatatgta
    55081 ctgcaattgc attattgtta ggaattggag gagcgtctaa gtgttcattg gaattaggtg
    55141 ctaaaaattc agaaaaagct acaaaagcag caggaaattc tatatgcttg atggctgttt
    55201 ttggaataag tttatttata gtagtatcaa tatttttaac accactatta aaattctttg
    55261 gctctacatc agaaatacta ccttatgcac acacatatac aaaaattaca tcaattggat
    55321 taccatttct tataatgtcc actggaatga gtaagttgat acttgcagat gggagaccga
    55381 aagcttctat gttttgtatg ttaataggag cagttattaa tacaattttg aatccattat
    55441 tcatttttgt ttttaatatg ggaattgctg ggtctgcttt agcaactgtt attgggcaac
    55501 ttatatcttt tggaataagt gttcattata taaagaattt tcaacatatt aaattacata
    55561 agaaaagttt taaattagat agtataattt ataaacatat atttgcgcta ggttcaagct
    55621 catgttttaa tcaattagca atgactgtaa cacagatagt tatgaataat acattggcat
    55681 attatggggc taggtcagtt tatggaagtg agattccact tgcttgtgtc ggtatcatta
    55741 ttaaagtaaa tatgattttt atatctataa ttattggtat atcacaaggt atgcaaccaa
    55801 ttatagggta taattatggg gctgaaaagt ataatcgtgt aaaagaagca tataagtttg
    55861 cagtgggaag tgcaactatt atatctgtta ttgcattctt atgtttccaa ttattcccaa
    55921 gacaaattac gtctatattt ggtaacggaa atgagactta ttttatattt gcagaacatt
    55981 attttagaac tttcttgttc ttaacattta taaatggtgt tcaaatagta tcatcaactt
    56041 tctttacatc aattgggaaa tcagtgttgg gactttttac ttctttgact cgtcaaattt
    56101 tatttttaat tccattgata gtaattttac caatgtttat gggaattgat ggagtaatgt
    56161 ttgcaggacc aatagcagat gcagcagcgg caatggtatg tatatacttt gcagttcatg
    56221 aaatgaaatc attgactata aagcaaaata atttgatgag taaccataat aagattgcag
    56281 aggtataaga caatatttaa gaagtataga aaattaattt aaagaagtat aataaactaa
    56341 tttaggaagt atagaaaatt aatctaaaga agtataataa actaatttag aaagtataga
    56401 aaattaatct aaagaagtgt aataaactaa tttaggaagt atagaaaatt aatctaaaga
    56461 agtgtaataa actaatttag gaagtataga aaattaattt aaagaagtat aataaactaa
    56521 tttaggaagt atagaaaatt aatttaaaga agtataataa actaattcag gaagtataga
    56581 aagctaatct aaagaagtat agtaaactaa tttaggaagt atagaaaatt aatctaaaga
    56641 agtataataa actaatttaa gaaatataga aaattaattt aaagaaatac aatacattaa
    56701 tttttaagta acattaaatt aatgtaagta aaataatgtt catatgaaga tttaaaggtg
    56761 cattttctga agctaagtat atgttgtaga gtgttaggtc tctctatcct gtgaagttta
    56821 atagctcaag aaaatgcact atttatgatg attattttgt tttatttcca attttggaaa
    56881 taactattct aattaaatct aaaattatac cataaataag aaaagaaagt atagatgcta
    56941 tgtaccaata aatcgaaatt gaccctgtaa ttgttctaca tgggatttgc atacctgaat
    57001 ccataaaaac aaaaaaacta tcaactctgg aaataataga caaaatagga tttaaaccta
    57061 ttagaacaat actttttgag tcttgaccaa tttgatgcat ataaatctca aataatgcaa
    57121 ttaaaaaaaa ccaaaatgta aaagatttaa taattttttt catcaaaata cctcacataa
    57181 tataaattct gtttgcacta tttgcttact acaactattt atctccattc agtcacatca
    57241 cttaattgta atctaggtct tcttgatggt tcttcatcag gataacccaa agatattgct
    57301 gccactaatt gactatctgt atttaaccat tcacataatt cacgatatgc aaagtataca
    57361 tcacaaatcc aaagactacc tagacctaat tccacagctg taagcgacat attctgaatt
    57421 gcagctccaa ttgattgcat gtttgccatt tcatagaatc gttcttcagg ggatagcttt
    57481 tctaaaggtg atttacctaa tatatttaaa ataaaaattg ttactggagc ttgtttcatg
    57541 atttcaactg tgtaatttgc accagcgata tgttgacgac ttcctggaag aagcccatta
    57601 tcattaattt cattttgaat acctttgctc atggctttaa gcatagattc tttttccttt
    57661 tcagtgatga caacaaaacg ccatggttgc ctgtttttag atgaaggtgc atttattcca
    57721 gcttcaatta ttttctctat agtttcatgt gaaatgcttt gatttttata ttttctgata
    57781 cttcgtcttt ttgatataga atcacttatc attttaagta acctccgttt attttttgga
    57841 aaaatctatt taatttttat tttctatttt aattatttta gcattaatca gaaaaaaagt
    57901 cattgatttt agtatacaat tattaatgat tatattaaga attgtatcaa aaagtatgtg
    57961 attatactaa gggattatat taaacattat atttaaaatt gtatgaaagg ttgtatttaa
    58021 tattatattg agagatatat atattaggat ttatatatat tcagatttat tattatattg
    58081 agccttatat taaattaagg actataattt gaaaataagc tataaaaact taatattgtt
    58141 ttgttcagag ataaaaaaag aatactttag gtgattttta ttaaaaatta agagtgataa
    58201 aattatatac tttataaatg taaatatgac gaataaaaat gataaatata ataatatata
    58261 tatttacatt aggagttttc tatactataa ttatttaaaa ctaaatataa atgttggaat
    58321 tatttaggac ttgaaattgt ctaaaaataa atacaagtga tgaagaggtg atgtgatgag
    58381 attagatatg gatagtatgt tatatgtact aatttatatg acattattgg tatctatcat
    58441 tggaagtata ttttattttt gtaaagacct cttaaatcat aaaattaagt atgttttaat
    58501 aagagacata tttgtaaata gaattacata ttctgaagaa cgactgccta aacagtatat
    58561 agtttttcag aaatatgata tttggaggta ttgtagtttg ttttaatttg aaatgaatct
    58621 attataaatt ctaaagttta aaaataaaaa ggagagaata aaatggattt catttcaagt
    58681 atattgcaag gattattaag tatattattt aattttacag gtgattttgg aatttctatt
    58741 gtacttataa ctttaatagt taaattagta cttatgccac tatcattaaa acaaagattt
    58801 tctgtaaaaa aacagcaaga attagctgaa aaaatggaat atataaaaga aaagtataag
    58861 aatgatacta aagaattgga aaagcaaata caagtaagtt ctgtagaaag tatgaagagt
    58921 atgctgggat gtcttatagt tttggttcaa atgccagtag tatatgcttt atatcatgta
    58981 tgtttagata tgacaaagga atttacaaca attataattc catggattgc taatttaggt
    59041 acatttgata atttgtttat attaccttgt atatatacat taattatgtt agcttcaaat
    59101 ttagtgaatt atataccata tttaaaaata aattctcaag taaagtttaa caaacaaatg
    59161 gctgtggtga ctaccataac aagtcttata ctaactgtta gaactccagt agccataggt
    59221 ctgtacttta taacaagtgc aatttattca ttaattgaag atatttgctt tagaatatat
    59281 tttaatcgaa aaaatagaat agtgacaaaa taatataatt attattagaa atattttagc
    59341 ctgctaacat agaaaaagtt agtaggctat ttttatctat gatatcaatt ccattaagaa
    59401 tagtctaaaa aatactatca aaatgctata aaaaatacta taaaaaaata gttgaaaaat
    59461 aaataaatta atataaacta aaataaagcc tacaaaaaag aggtgataaa tagaaatggc
    59521 taaaatacta gttgtagaag atgaaaaaag aatgcaaaat attattgtag aatatatgca
    59581 aaagggagga tatacttgta taactgctga tgatggagtc gaggcactta caatattaaa
    59641 gagcaacaat atagatttaa tgatattgga tattatgatg ccgtatttag atggattttc
    59701 agtgtgtaga gtttcacgtg aaatgactaa tatacctatt attatattga cagctaaagg
    59761 tgaagaggag gataaattaa agggttatga atatggcgca gatgattata taacaaaacc
    59821 atttagccca aaagtacttt tagcaaaagt taatgctttg ttacgtagat acactactga
    59881 tattcccaaa aattcattga gtttaggaaa gatttttatt atggtagcat caagacaagt
    59941 gtatgtagaa gataaattga ttgatttaac atataaagaa tttgaattat tgcgtttatt
    60001 tatggaaaac cctaatcaag ttttttccag agagaaactt ttaaattgta tatggggata
    60061 tgattttgaa ggaaacacac gaactgtaga tacacatata aaaaccttac gcaaaaagct
    60121 tggtagtgaa ggacaccata tagttacatt aattcgttca ggatataagt ttgaggttaa
    60181 ggaatgaata gtttaagaaa gattatagaa aaactgaaaa atgtagatat ttcaaattgg
    60241 attaaacaaa attttggact atattcagtt agaaaaaaag tgtttttact ttctaaatta
    60301 tcaggagcgt taattatatt attttatctg gttgttgaag aattttcgat aaactctaaa
    60361 tttgaatttt ggatttggtt tataatactg gttatattta ttatgagtat tgatttctta
    60421 ttgggaaaat ttatttcaga accaatcaca tctataaata aatctgcaaa aagtatgtcc
    60481 caacttgatt tttctaatcc atgtactgta aatactaatg atgaatttgg agaactttct
    60541 aggagcctga atacaatgtc tacaaatcta caacaggcat tatcagacct agaaagtgca
    60601 aatattcaac ttgaaaagga tgtaaataag gaaagaatgc tattggaaca aagaaaggag
    60661 ttggtagata caatttcaca tgaaatgaag actccacttg gcattatacg tgcgtataca
    60721 gaggggctta tagatgaagt tgatgaagaa aaaaagaaaa attatatgaa tgttataata
    60781 gaagaaactg atagaatgaa caatatgatt gtatcattat tagacttatc tgcattggaa
    60841 gcaggagttt ctaaacttaa cccagagcgt tttgatttta tagagtttgt tgaaactgtg
    60901 gcaggtcgtc ttttaattga tataccagat gccaattttt attttacata tgatttgcca
    60961 gagtatgaag tttttgtagt ggcagataaa atgagaatgg aacaagtagt agagaatcta
    61021 gttattaatg caaagaagca tgttgtatat aatggtaatt tagatttatc gattacatgt
    61081 gaaaatggct tgcttttatt tgaaatttat aatgatggta ggtttataga gcaagatgag
    61141 atttcaaaga tttggtctaa gttttatcgt agtgttcaat ctcagcgtac aggaggttca
    61201 ggtctagggc ttgcaattgt ttcacaaata cttacaatgc aagggttaga atatggagtg
    61261 aataatcgtg atagaggagt agagttttat tttatgattc caattgatga ataatttagt
    61321 attaatttat aaattataag tatctgatgt aaaatatttt tatttgtata cgtaagtatt
    61381 taaagagaat aaaataaaaa aacttaatga aaaagcttaa tgaaaaagtc taataaaaag
    61441 cttaatgaaa agcttaataa aaagtcttgt tttcctgatg aaaacaagat tttttattaa
    61501 gctttttatt atttcacttc gatttcacaa gagagacact ctgatttcac caaatagaaa
    61561 taaaataggt taaataaatt aaaaaataga agcgtaatta aataaggtta caagggggag
    61621 tacttatgaa atggtataca tggttgacta ttatattgat aatattgctt tctattccgc
    61681 ttaaaattaa atttataaaa tggtgggata gacgacaaaa aaatgataaa ggaggttatg
    61741 atagatgata aaagtaagag agttaaaatt ttcttatgga aaagataaac agatattgca
    61801 tggacttaat tttgaagtaa aagaaggaga aatctttgga ttccttggac ctaatggttc
    61861 aggaaaatcc acaacacaga aaatcttaaa tggtgtttta aaaggttaca atggtcacgt
    61921 atccattttt ggtaaggaag ttaaagcata cacagaatct ttatatcaaa agattggtgt
    61981 tttatttgaa tttccttatt tatataccaa tttaagtgca attgataatt tagaatattt
    62041 ttcgtctttt tatcctaaaa atcaaaggag agacatatat gaactcttag atttgttaga
    62101 gtttaagaaa gagtttataa ataagcctgt atcatcctac tcaaaaggta tgaagcaacg
    62161 tattagcatg gcaagagcat tggtaagtaa tccaaagttg ttatttttag atgagcctac
    62221 tagtggactt gacccatctg gagctgtact atttcgtaag attattgaag aagaacgaaa
    62281 aaaaggaaca actatctttt tgactactca taatatgcta gatgcagatt taatgtgtaa
    62341 caatgtggct tttattgcag atggaaagat tatggtaata gataaaccca aaaatttaaa
    62401 aatgaaaaat agcaataata aagttgaagt ggaatttgta tataatggaa atcgagatat
    62461 tgaaattgta gatatacaag agttagaatc tggaataact tttaaatatg atgaaatctt
    62521 aagtgtacat tcaaaagaac ctacactaga agaagttttt attaaataca caggaaggat
    62581 gttagtgtaa tgtattctaa attttttacc ttagtaaaaa aagatttttg gatgatgatt
    62641 tatggtaaat tttttgtgct gacacttggc tctctcatac tttattcgtg ttatattaat
    62701 tttggttatg taaagtttat ggatgaagat agttatcaca ataatgtata tctatataat
    62761 ccagagaata taagcatgag tgcatctcca ttaattaatc aagtttcttc tataggtgaa
    62821 ttaaaagcaa aacttgatga agatacaagt gcagtttgta ttgatatgag ttccagtaag
    62881 ccgaaagtaa ttttacatga aagtattaaa ggagttgaca attatagagc tgactatgca
    62941 ttgtcattat tatcatcaga aaaagaccat aatagcaaaa tatcagacaa caatgcaata
    63001 attcaaatta atgataagga tacatctgag ataaaacaaa gaaaagacat gacttgtgag
    63061 attttattct ttgaaattgt agctattgga tttttaggga ttgcctcttt attatttaaa
    63121 gaaaagcaga tgggagtaat gcgtattact ggtattttac ctgtaaaaag aagtcttttt
    63181 atattatcaa agatatttgc tttttttata tgtgacctat gttttacagt tcttttagta
    63241 gtatttaata ttggattttt agaaggaata aaaatacttc cacaagtatt agttcaagct
    63301 agtattttat caattattat gtctttgatt ggaataggat gctcaatgtt attgagagat
    63361 tttaagcaat tttctcttat atatcttgtg gttgctgtat tcataactac acctatattt
    63421 ctatctgcaa atacatcttt tgaaatagat tggattaaat atcatccctt ctatcatgtt
    63481 tatagtcagc ttaaaaatgc gtttttcatg aatttttcaa aagaattagt ttattttgta
    63541 gtgtgttctt tgacaataat agttctattt ttacttgtaa aatatatttt taataaagaa
    63601 ttggttaggg agggataatc ttgataggat tacgttacca gttaaagagt ataaaaaaag
    63661 ataaaatgtg tataatttcc ttctttttac cagttgttat ggcgatttta ataaatttta
    63721 tgggaacaat tgatatatct tcattaggag agatacgttt tggtatagtg aaggatacac
    63781 ttcctgtaca aacagagcag tggttaaaga agtatggtat ggtaagtgta tatgacacaa
    63841 aaatgcattt aatacgtgaa attaaggata ttaaaacgga cacaattgga gttgttagag
    63901 atggtaaagg aataaaaact gtgttttatg gaaatgagat taatgctata aaaaatgttg
    63961 gaaagacatt gccagagatg tttagactaa agggtgattt aaaagatgtt gaggttacaa
    64021 tattgcctaa agatagtatt ttaaaagagt ttcaaaatgt ttttattgct atgattttaa
    64081 ttactgctat gtttatggga tgcaccttta atgcaatgaa tattatatcg gaaaaagaag
    64141 atggaatatc atttataaat gaagttttgc cacagagtag aagtcagtat attatacaaa
    64201 aagtattttt gggtctttta tgtgggtgtt tatcttcaat gataactgta tttatatgtt
    64261 tggatatttc aatattagat atgataatga tgttgttact cgttgtattt tcagcattta
    64321 tttcatcact tataggttta tttattggaa agttgtcaga aggtcttatg gtaggaattg
    64381 tttatattaa aatagtaatg attttattta taggtactcc tttgttaata tatcttctag
    64441 gggttaatac cagtggtata gggaatttat gctatataat gccttcagtt gctacattta
    64501 atggtattat ggagattatt aatggtaatg tcattattat caaagatatt gtaattttgg
    64561 ctgtacattg tgtagtatgg tttatgatat atattatttt agataaaaaa agaaagttat
    64621 cttttagtag ataactcagt ataattataa ttgggacaat ttaataggtg atttaatata
    64681 ctttgtatag tgtaatttat gtagtgcaat ttgtatactt taatttatgt agtgtaatag
    64741 ttagttttat tttataatta ttcaatataa tttagtaaga agttcagtac aattagagct
    64801 acttagtgga aaacttaata ggtacttaaa ctatataaat actttatttt cctccatttg
    64861 tactataaat ttaatttatg atataaatgg aggtattatt atatgatttg ataaatttca
    64921 tcattataac ctacaagtaa aggtattatt atataaagtt aataaagata gtatcaaaat
    64981 attatttgct ataaagagag ggactcaaaa taaagataaa cctatttttc aatgttgaaa
    65041 tgataaaata tatttgattt catataaaaa attttcttca taaattaaaa agtccatttt
    65101 aagccccttc atttttaacc agataaatcg agttaaacta tttaaatata ttactcggat
    65161 tcatttgact tagatattcc ttgcttgtaa aattgttttg aataggggat agccaaagca
    65221 aaaaataaaa gtataatccc tgctatgatt attaaattat taatagaaat tacatctgcc
    65281 attggtccga aaatcatcat accaagagga ataaaaccag tatatataat aataggtaag
    65341 ctaagaactc tacctagcat ttgtggtgct acatgctctt gcaacatagt catagctgat
    65401 gcttgaatga ttggaattga aaaattcgta aaaaacataa atataaaaaa ttgccaagct
    65461 tgtgttacaa gacctagaat aattgaaaaa atagcatagg ataatattgc tagaaaaaag
    65521 gtcttatttc tatttttaaa accaccaaaa actcctataa tcaatccacc taaaaccata
    65581 cctaaaaatc caatcatttc aataatagac aggtatatat aacccttgcc aaatgttcgt
    65641 tcaataagaa gtcctataag aaatcctgat ggaacacaaa gaagcatgaa tgctccataa
    65701 gtaaaaagca cttttctaat gaacttatct gaaaaacagt actttatccc tgataccata
    65761 tctgcaaaaa atgagacttt ttcagtttgt tttggtatat catgtttagg aattttgatg
    65821 aatattaata atacaatagc aataattgca gtaaatacat caattaaaag aacttgattt
    65881 attttattac caaatccaag tattgcagca gctacaatag gaactataaa ttgtactata
    65941 gactgtagac tactatttat accattaaaa cgcattaaat gttcttctgg tacaagttga
    66001 ggaatcattg cgtttacagc aggtgtttgt acaccacttc ctagtgaacg tataacagat
    66061 attactgata tggctattaa ttcacttgtt gtgccatttg atgacatcat aaatagaatt
    66121 agaactaatg tagatatagc aattgttgaa tctgatacaa ttatgagtac ctttcgattg
    66181 tagtagtctg cccatacacc agcaaaaaaa gaaattatca tttgaggtat aaaggagcat
    66241 acagttaaaa ctgttaccca tacacctgat gatgtctgaa gtgtgacata ccatatcatt
    66301 gccatttgta caagtgatga gccaaataag gaaatatatt gacttgctaa aaaaagaatg
    66361 acttttttct tccatgtaga attagtattt ttattttcca tcctattcct cctttgattt
    66421 gtgtgttgaa tttttcttgc tcttaaggat aacacacaaa tcaaagtctg gagttagagt
    66481 ggagggctag gaaaattgtt ttttcataat ttgaagatga gatttcatgg tttttgcatt
    66541 atgttcagct tctttcaatg aagttatcag tttgtcacac actgagataa tttcgtcatc
    66601 atcttttgga gtgtcaagga cagttttaat attagtatta ggactagaag ataaagcatt
    66661 taacattcgt aaaatagctg aaagagaata gtttgcacaa cgaagtgcgc ttataatttt
    66721 aagtcgtttt atatcttcat cagtatatac acgataacca ttttgttttc tttttacttt
    66781 taacaaacca ttcatttccc aatttcttaa agtatctatt gtaacgttta agtgttctgc
    66841 agtttctttt ctagttaaaa agagtttatt tgtttctgga gtatttccat ttaaaatctg
    66901 tgcaacaata gtaagtgctt cctcggcatt agatttttct atttctaatt gttgcaagta
    66961 ttgatttaca agactaatag ccttatcaaa gtccctattc gctgatgttc ttacaatctc
    67021 aagggcatct tttcttaatc ccctttgtac cacttcaatt ttcaaggctg tacgagcaaa
    67081 tctaaattgt tctatatgaa aatcattaaa gatacgataa ccattggtat tacgcttagg
    67141 tttaggtatt aagtttagtt cttcatataa acgtactgta ttaggatgta caccaattaa
    67201 atctgctacc tctgatgtcg tgtaagtgtc cattagtatt caactccttt tagatatata
    67261 gtattagtca taataacacc aaacaaaagt ctggtgttat aatggagggt ttggctatct
    67321 aagagtaatt agtttatgaa agagtaatta gtttatgaaa gagtaattag tttatgaaag
    67381 agtaattaat ctattataga agtaagtata tatttttcaa tgaactccca tctatcacga
    67441 ggtttaaaca ctattttaga tggtatggct attactaagt catattgtgg aatacaacaa
    67501 atagcatttc ctccagttcc cattgctgaa taccacaaaa caccatcttt tttacatagc
    67561 caccacagat aaccgtattc attactattc attttaactg attcttcaat ccacgattta
    67621 gatataatac gtttattatt ccaaatacca tcatttaaat acagaaaacc aaatcgcaac
    67681 atatctctag cactcaatgt aagtccccag ccacctatag aataaccctg tctatctttt
    67741 gcccaaccct taagattttt tccaaagaaa tcttcaaaac caaaatcttt catatcataa
    67801 tctggtataa ctttcatacc aataggttta aataagtact cattagcaaa ttcacgagca
    67861 gattttccag tagtttttgt tataatagct gaaagtaggt gcgttccagc tgaagaatat
    67921 ttgaaagtac caatttcgcc tttttgacca agttgattca aggtatattt tatccaatct
    67981 ttttgtttgc aaagtctttc taaagactca gtcatatttt taaaagggta tggtgcagtc
    68041 attgtaagta ggtgacgtat agttactgct tttttacata tttcagaagg actacaagta
    68101 tattcaggaa aaaaatcaac aaccttttgg tcaacatctt ttatatatcc tttatctatt
    68161 gcaataccta ttaaggctga tataatactt tttgtaactg atgcaacatg aaaagtatca
    68221 tcagcattat atccattata gtacttttca aagacaattt ttccttttct tgcaataatt
    68281 ataccattta tattgctata ttgtgagatt attaaaggtt caagttgtga aagcttttct
    68341 gaactcatac caacacttga agggtctact ttttcaaaaa ttaagtctaa gcaattgttt
    68401 ttattcatta aagatacctc cctgttatag attttggatt ttcttttaga gtttttggag
    68461 aaccttctgc aattatataa cctcctttgt caccaccttc tggaccaagc tcaacaatcc
    68521 agtcacaaac atttaataca tctatatcat gttcaacaac aattacagaa tttccatttt
    68581 caaccaattc atctaataat tgaatcaact tagaagtatc atatagactt agaccagtag
    68641 ttggctcatc caatacataa aggatattac catttcgttt tttaccaatt tcttttgcaa
    68701 gtttgattct ttgggattca ccaccactta aagtcggtgt aggttggcct aattttatat
    68761 accccatacc tatttgttct aatacattta agtgtgaaac aatatttgga atatctttga
    68821 agaaatgtac agattcagaa acactcatat ttaaaatatc atgtatattt ttatttttat
    68881 atttaataga taaagattca tcattaaatc tttttccctg acattcactg catatatggt
    68941 ctatacttag attatttccc aaccagacct tttcatatcc actaccacta catttaggac
    69001 aagccccttt ggagttaaat gagaaatgac cagctgtaaa tccttgttct aacgattctg
    69061 gctgacctgc aaatagtgta cgtatcttat cccatatacc aatataagaa gcaggagttg
    69121 agttcatatt tttgcctata ggagattgag atatctctga atatccagaa atatgtttag
    69181 taccaatcag tctatctgca atagtttcaa caactgcata atcgtcttcc tcacctattt
    69241 cactctctga agaatttatt tgattattga tagtatggtt attaaattgg cttctaagaa
    69301 gaggaagtag ggtgtctgat ataagtgaac tcttgccact acctgatttt ccagatattc
    69361 caaccatagc acccaaaggt aatgatacag ttacattttt aagattattt gtatttgcat
    69421 tttgaatagt tatacaaggt attttatcag tatgtgtaat gtttttattg cttgttctat
    69481 taggcattgg atattttcca gatagatact gtccagtaag tgatttgtcg gattgaagta
    69541 gaccttctaa atctccttga tatactaatt gaccaccttc aacaccagct tttggaccaa
    69601 tatcaataat atgttctgcc atttcaattg tgtttttatc atgctcaact actatgaccg
    69661 tattgcctaa atctttaagt ttctttagtg attttaagat gtctattttt tctgattcat
    69721 gcaatccagc tgttggttca tcaagcacat aaattaatga gtccatctct gaatcgagat
    69781 gtgaatttaa aaatagtctt tgcatttccc caccactcaa agttgacatt tctcggtata
    69841 aggatagatg acctaatcgt gattctatta aatgttgagt tttggataaa atatcattta
    69901 caagatttgt accaaatgtg tttaaattac cttgatttat taagagttta aggaaatcat
    69961 caatttctaa aatcgtcatt tttccaagtt ctccaatatg ttttccgttt aaaagtactc
    70021 tacgtgcttc ttcaccaatt ttaaaaccat tgcaatctga acaggcagtc atagtataaa
    70081 ctccatttaa atcttcgccc cttttgtaac gattgtgaaa tacctttgat aaagaggaac
    70141 tttttttacc attttcataa tgaccataga gtacttcatt tcttatttct tcaggtagtt
    70201 gtaagaattg tatgtctaaa taatcattga attttttaga aaatactctc aaatatccag
    70261 gtgtaatctt tgctctatct aagacttgtt ttagggtatc atgcttatca aggactaatt
    70321 tttcaatatt aatctcaaaa tatgcaccat gtccagagca cttcatacac attccatctg
    70381 aagagttgta tgagaaataa cttggtctta atcgttcttc ctcatatcca caattattgc
    70441 aaattagatt atcgcttaca ggagtatcac acatagtaca cattatttga ccttccactg
    70501 aatacaatag tgtaagcatg ttgagaatat tggttcttgt gcctactgtt gaacgaggat
    70561 tgctctggcg aataatattt tgttgaacag ctatagtggg agctaaacct tgaatattat
    70621 caaacttatc ttcactatca atacctgcaa gtatacctaa agattgcaga tattgtttac
    70681 gcccttcctc aaatacaatg tcaaacataa ggctagactt acctgagcca ctgacacctg
    70741 ttgcaacaac aagcttatct tttggaatag aaacatctat atttttaaga ttgtgtatct
    70801 ttgctccatt aatttttatt tctttcattg gttcacctca ttttatcaat tttatcaaac
    70861 cgtaaaatag ggatatatta atccttaata caagaataga ttaggtgagg ttattaaaaa
    70921 ggttctatag gtaaatatat atcgaccaag tgtctatttt gagggtgatt gtgtgggttg
    70981 ttaagatata cttcaaaagg gaaggaggca cgtagcttat aattaccatt tgatagccat
    71041 tcattataca taaaatccca cgcatcacta tattcagatt ttgaaatatc aaaatgtccc
    71101 acaagatatt ttccagaagg tattatcata ttgccaagat tgtcattctc tttgacaaca
    71161 atgttatctg gaatggtcat gcaaatacta gtccttaatt gatgctcctg tgtaaattgt
    71221 ggattatcat gataaatggc taatatttgt gtgttttcaa gtccaagtag attctgctca
    71281 cttgcatatg tgaataaccg ttctaaaagt tttgggaaag tactggttag attaccatat
    71341 gaaccagtat atctagtgta aatagtattc atattatcaa gttctagaat ttcaatttca
    71401 cctttaacct ctctagtatt cttacattta ggttttgata tgcttctatt gtactgagaa
    71461 attttatatg gttctttgca attcttgcta taattgtttc tatattttat agggcttatt
    71521 ttatagtaat ttttaaatgc tctcgagaaa actgctgaat cagtaaagcc gaagtagtgt
    71581 gcaatatcag taacagtcat gtcagttcta tgaataagaa aagcagttgc attttctagt
    71641 tttagcctat ttacatattg tgccaaagtt tctttttcta ttgctttgaa gattctatga
    71701 aaatgaaatt ttgaaaaacc tgctatatta gaaagttcat caagagaaag aggttcatgt
    71761 aaatgttctt ctatatagtc ttgcactttg caaatacgat ttagatattc ttttttactt
    71821 ttagcatttg tcatatatag ccctccttat tgtgtaaaat gtgtatcaat taatttatag
    71881 caatatagta ataaaatttt atgtttttgt aatttatgat aaataagata gcgtttaatt
    71941 ttttataatt gataaaagat ataagatgcc ttatatttgt ctttgcatat aagtatagtc
    72001 ttcgtaataa ttagtatacc atagtgattt atttttaatt gtgtatttat ataaatacac
    72061 aacttatgat atggacgaat tattatgcaa ataagctgta attaaataaa ttgcaatata
    72121 aaccagttga aacataagtt agggaaatat tatcaaagtt attacttagc ataagagtat
    72181 agatggaata aaataagatt aaaaaattac atactaaatt taataaaatt tttatattaa
    72241 aaataatatt aagtttattg tttaaataaa aaagttaaat ctacactatt aacttattat
    72301 acttaaaact ttaaaatgaa aatatcaaag aatacttttt aataaaaata atcatttaat
    72361 aagttattta aaaatctaaa aactttacaa caaattatat atttaaattg gaggagtggg
    72421 aatatgagta atagttttta tcaattaaat tcagcagtat tatattttaa tgaaaaaaga
    72481 gatgtaaata gaataaggtt taatcactat gtaatgagaa aagaaaatat acaaagatta
    72541 aaaggaactc tgccaagagg acaatttatg atgacagtaa ggaaagctgc atctgacctt
    72601 gatgtatcta tatctacaat aagtagactt gtaaatgaat ttatagattt aggtatattg
    72661 agattaataa gtaggggagt aaagggaaat tgttgttctg tatatagtta tgtttgttct
    72721 gaaagtagta atgcagaaat tgtaacaaag aatggtgata ttttcaaaaa tatagagaaa
    72781 tacattgatg caactattaa caataaccaa aaaacaatga aatataaaca tagaaatgag
    72841 ttgtttaaga acagtaatac caacatatac agccgtataa atcaagagag tatagacaaa
    72901 gattatgatt tgataattca tactgggtat gaaacagaaa atgagacaaa gaaaaaagaa
    72961 ttattaaaaa ataatttaaa taaaaagaat ttaaataaaa atacctttga aaattcggat
    73021 gaagatttga ctgaagattc tacttacaaa aatccagaaa gcatacatga aattattata
    73081 agaaaattaa atagtgaatc aggaaaaaat tttaaagctg atttgagtat aactaaggca
    73141 cttatagata aaagattaaa agaagggtat agtttagaag atttttacaa ggttatagag
    73201 gcaaaggtaa gaagatggag atatacagat atggaaatat atatagaacc aacaattctg
    73261 tttgggtatg aatttgagtc gtatttaaat gaggagagtt ctttatctgc ttgtaattat
    73321 ggtgatatgt gttatgaaga tatgtattga gatatttatt aagatattag ttgcttttta
    73381 gttgtttaaa atatgtttat gtataaatag tgtattaaaa tggagttgtc tcaaaataga
    73441 gagaagtctc ttcttaattg tttaaatgat gaaaatatat ttgatttaat acaaaggaga
    73501 gtgctttatg agttagaaga tttattttga gacactcact ttttttaata tactggagaa
    73561 atataaccca ttttacaaga gtgcatagat atatataatg gcataatgtg gatttaaatt
    73621 aaaaaaataa aataaagcca taaatattga aaatttcaat atttatggct ttattgcttg
    73681 taataattaa tagaatatat attttttatt aatcatctat ttatattttt tattaatcat
    73741 ctatttcaaa ttctaatatt ttaccagtaa ttgcattaat tgttatctca tattcagttt
    73801 ttccttttat tatttcacct tcatattctt tgtcatcttc atcatactta aattttacta
    73861 ttttcccacc aggcacttta tctagcatta ttgatttagc tttttcagca ctaataatag
    73921 aactgttgtc attagtatta gagttattct tatcattatc atcaaagtca tcatcagaat
    73981 cattgtccat gtcaatatct acaattcttc catcaaatgc acttatctct aattcatatg
    74041 ttttcttatt ttttattact ttagcctcat attcgttatc ttcagcatca tatttacaat
    74101 agattaaatt accattagga atagcatcta atgctataga cttagcttta tccaatgata
    74161 tattttgtgt acctaaatta ttatcattta agtcatcatc tttttcaatt tctattattt
    74221 taccagagta ggcatcaatt tctatctcat ataggatatt atcctttata actttgcagt
    74281 catattcatt atcatcttca tcataataac aaactaaaat attgcttcct ggaagagctt
    74341 gttttaatat ttctttagcc tgtattaaag atattttttt agttttattt cttatgttca
    74401 cattttttag ttttaaaata tcttcaaatg ctttttgatt atatcctcct cctacttgtg
    74461 ttatttcatc tatatcttta tttttaataa attctttttg actatttaca aggctaccat
    74521 tagatatcat tataggagaa ttttctttag cagctagtac tcctattgat aatgaatcta
    74581 ctaatgcatt ttcttggtta ataccatctt tagctacaaa tacattattt atttttttat
    74641 ctttataaaa tttatcaata atttttgcat tagtattgtt tctatctgaa ccactgattc
    74701 tttctctgtt tggatatttc tttactgtat tgtctgataa aatcttattt cctccaacta
    74761 tgtaagattt ttttatagac ctattgttta agaaatttat actactatca ttgctgtttt
    74821 catctgatac taatattata ggcatattat gtattgctgc tggagaagct atactaactg
    74881 catcagatag tccctttagt ccatttacaa ctgcaacatt ttctatcttt tttatcttat
    74941 ctatttcttt aagtacattt gtagacattt catatatatt gtttcctact attttattta
    75001 tttttatgtt aagtgatttt atttcatttt ctactttaga agaaatgcta tttccactat
    75061 ctacaatgta cacattatct acaccaagcc ttttaagctc agccttagtt gaattttcaa
    75121 tactgttgtt gtttactaaa agtataggtg cattctttag cttagcaaat ggatttgcac
    75181 aaagcgcact ttgaatagaa ttaccattaa ctataatggc tgtttttgat tgaacccatc
    75241 ccaatttact tacttctact gctgtttcat atcttgtttt acctattaat ctttcttgct
    75301 ttgtagtatt gtctgcaaaa attgctgaag aactagaaaa aaacatcata cctgatatta
    75361 atatagctaa atttttctta ttcatatttt tacctcacaa tctttaaaaa tttgttattt
    75421 agcatactta ataaaatata atcttaaaat caaattgata ctgagtttga agttacaaaa
    75481 tcaacaaata agatttcttt aatacaaaat tttccttttt atatttaaca ttgtatcaca
    75541 aatataaaaa ggaaaaaact ttttaaaaag ggtatacact attcattttt tatcttataa
    75601 ataagtcttt atcactgttt tatatatttt aaaatagaca caagacctat ttctaaatct
    75661 tttataaata ttttaggtga aatttctttt taaacatatc taaaaagtat ttgtagtaat
    75721 attaatggac tgaatttctt aaagtatata tttctttaca tgttggagtt tgtgaagttt
    75781 gagaattgga gggtgaaaga aacatgtaat ggattaatat taaagaactg tatttttata
    75841 atatttgtct taaaaataaa aaaatctatt gacttgaagt taactccaag tagtaaagta
    75901 taattataca agaattatat acttgtaaga atagttaaag tagagagaaa aaacaaacaa
    75961 gttttaaagg gggaagtaaa acaatggagg caaaaaaatt aggatttgga ttaatgcgtt
    76021 taccaataaa agatgaaaat gatgttacaa ctattgatat ggaacattta aataaaatgg
    76081 tagacacttt tttagaaagg ggatttacat attttgatac ggcctatgtg tatcacatgg
    76141 gaaaaagtga gatagcactt agagaatctc tagtaaaaag acacaaaaga gagagtttta
    76201 ctatagctac aaaacttcca ttaatggctt taaagaaaaa agaagagcaa gaaaccattt
    76261 ttaatgagca attagaaaaa tgtggtgtag actattttga ctactatctt ttacacaata
    76321 taggcgtgtc acattatgaa gtagctaaaa aatttgatag ctttaagttt attgaagaaa
    76381 agaaaaaaga aggaaaaata aagaatattg gtttttcttt tcatgatagt gcagaattat
    76441 tggataaagt cttgagtgag catccagaag tagacttcgt gcaattacag attaattatt
    76501 tagattggga taatgaaagc atacaatcta gaaaatgcta cgaggtggca gagaagcata
    76561 ataagcctgt aattgttatg gagccagtaa aaggaggtac acttgcaaag ataccagaaa
    76621 aagcagagaa attattgaat gactacaatc cagatatgtc aatttcatct tgggcaatac
    76681 gttttgcagc aagtaaagat aatgttatga tggtcttaag tgggatgtca aatatggaac
    76741 aattattaga caatacagga tatatgcaaa atttcaaacc attcgtacaa gaggaatata
    76801 atattataga tgaagcagta gagattatca acgaatcaat tttaattcct tgtactgcct
    76861 gtcagtattg tgtagaaggc tgtccaaaaa atatcgctat tccaaactat tttgcgttgt
    76921 acaatgcaga aaaacaagct cttaatactg gattttcaac acagatggtc tactataata
    76981 attatactaa aacttatgga aaggcctcag attgtattga atgtaaacaa tgtgaagaaa
    77041 gctgtcctca acacattaaa attatagatg ctttaaagaa tgtagcagaa acctttgaga
    77101 aataattcaa tctatacaat atcaagagga gaagatatgt atgacgattt cagaagttag
    77161 taaaaaatac gagctttcag cggatacttt acgatattat gaacgaattg gtttaatacc
    77221 acctgtaaat agaaataaaa gtggaattag gtcttttaca gaagaagatt gtgagtgggt
    77281 taatttcata aagtgtatga gaggtgcagg tctttctatt gagacattaa ttgagtatgt
    77341 agctatgttt caacaaggga gcagtactat caaagctaga aaagaacttt taatagagca
    77401 gagaaaccaa ctagcaaaaa gaatagaaga aatgcaaaaa actttggaac gattaaattt
    77461 taagattgat agatatgaag aaggtattat tgagaaagaa aaagtattaa agagcagtag
    77521 aaataagaaa atggaggcag tatcttatga gtaaaaatgt attaatagta tcagctagtc
    77581 ctagaaaagg tggaaattct gatttattgt gtgaccagtt tatacaaggg gtattagaat
    77641 ctaaaaatca agtggagaag atatttttaa aagataaaga tattaactat tgtactggat
    77701 gtggtgcttg ttatgaaaaa gaagcaaatt gttcacagac agatgacatg ggagaaattc
    77761 ttgaaaaaat gattggggca gatgtgattg ttttagcgac tccagtttat ttttatacta
    77821 tgaatgcgca aatgaaaact atgattgata gaacttgctc tagatatact gaaatttgtg
    77881 ataaagattt ctattttatc gttacagcag cagatgaaaa tgtggctgat atggaaagaa
    77941 caatagaagg atttagagga tttacatcat gtctaaatgg ttctaaggaa aaaggtatag
    78001 tatatggtgt aggtgcttgg aatgtaggtg atattaaggg aagtaaggca atgaaacagg
    78061 catatgaaat gggtaagttg gcgtagtatg tttgtataaa attgtataaa attgaatata
    78121 ttcttatcat ttcaacaata aaaagaggct tatctgtatt ttgagacagc ctctttgtgc
    78181 tatatcattt atttttattc tatatcctta ttataccctt tattttttta tgcctattta
    78241 agtatctgtt gttactcata tattttaata attaccctta aaaaactata cagattcctg
    78301 cataatatta ttttctttag taattaattt ttctaggttt ttccaatcca tttcttccat
    78361 atttgcaaaa taatgaccac ttcctatgca agtcaggtaa gactttccat ctaattcaaa
    78421 cgaagaacct ccaatacact ttgaattaca tttcttacaa gtacgagttt tagttatact
    78481 atctttaata gttttagagc attcctccac agcatcttta tatgtattta gatgaaaaag
    78541 atttgcttta actctccatt ttttttcatt acattcaata gtaaataagc tacgttttgg
    78601 tttcttagtt gaatatacta ttttgtaaga acgagcacct gtttttggtt caattttaca
    78661 atctaatgat ttaccaagtt catgtaaatg acatgcaata tcataatctt taccacttag
    78721 tacttctaac atttcttctg ttgtttctgc tgttaattca cttttgctca tattaaaaaa
    78781 atccccctat ataaataata atttcatatg aaaataatta atataagtat attaaataaa
    78841 actattaaaa tcaataaaat tactgcaatc ttacattatt gggcatagaa tgagagctaa
    78901 tgatttatta gaaataagac ttaatagtat gaaaatttac ttagacgtgg tacaattcta
    78961 taaaagattt aaaactagga aaggagaaag ttgttgagat acggccaata taacaattta
    79021 tttataagtt gtaaatttat tatgagatta attagattgt taagtaatac tatcaaaagg
    79081 tagttttttg gattttcagc aacagtggta gatattgata attttttggt tattattata
    79141 tttagctgtt atattttcaa taggctctat gataactagg gtaaataagg tatgggtaaa
    79201 ggttttatta tttataatag tgggattgtc aactatagtt ctttcatatg taataacttg
    79261 attatgcaaa attctatgaa gcaggaaccc tgtgacttta gtcatgggag gttcagaatt
    79321 taaggttaaa aaataacttt aatctgtaaa ttctcaaaac aagaattctc atgttggtaa
    79381 atttctagat atgagaaaaa aattgacatc ataaaaaagt aattttagag cgttttttta
    79441 cgaaaaaatt cagaagtaac tattttgaat gacttcacaa aattttatat ataaataaag
    79501 tttggcacgt taattgcttt aataaaagtt aacaagacac aaataaacat aatcatctaa
    79561 gtattgatta tttgaagttt tagatttgaa gtttaatcta aaggttcgta ttaatattgg
    79621 tgtttaggaa attttatttt cctgtaaata taacttaata ataggaggtg aagtcatgtc
    79681 aaaagtagta atagctacag agaaagctcc aggagcaatt ggaccatatt ctcaagcaat
    79741 tcaagttgga aacatagttt ctacatcagg tcaacttcca atagatatga agactggcga
    79801 gttagtatct gacccaaaag aagcaacaaa agcttcttta gataatgtaa aagcaatatt
    79861 agaacaagct ggtacaagta tggataaaat atttaagact acagtattcg taaaagattt
    79921 aaaggatttt aatgatatta atgaagtata tgctacatat tttaaagaaa atccaccagc
    79981 aaggtcatgt gtacaagttg ctcaattacc aaaagatgca gttttagaaa ttgaagcaat
    80041 ggcagtatta taagtattat aacaataaaa ccaataacaa aactaataaa aattaaaaac
    80101 taataaaaaa agtctacaat taaaaaagtt tatattaaaa aagtctatat aaaaatctat
    80161 ctaaatattt aactattgag cttttctcat ataatgtata tttttatgtc aaaaatatat
    80221 ttgttatatg aggaaagctt ttttttatta ttgtattgtg atttatttta ttgtctgcat
    80281 attataatta aggttactat ataaaacaaa ctttttataa attaatattg tctgttttaa
    80341 cgcaaatata taaataagta atgttttata tatattttaa agagtgacta tatgttaaaa
    80401 tatagctaaa ctgataattt ggtaaattaa attctaatgg gggaaactat gttaagtaaa
    80461 ttaaaagaat ttcaacaaga aatgataaaa tacactgaaa cagtagctag tgtgttagat
    80521 gtagatattg aaatagttga cgatagatta ataagaatta gtggtacagg tctgtataaa
    80581 tcaaagataa atgaaagcgt tgttactgag ggctttattt atgacaatgt tatacagaca
    80641 ggtcaggaat tagtcgtatt ggatatatgt gataatcagc tttgtataga atgttcccat
    80701 tacatgaaat gcctaaataa agtaataata gcagttccaa taaagtataa taatcgaact
    80761 ataggagtaa ttggtgctat tagcacagat aaaactaaaa aagtagaaat aagtgcaaaa
    80821 atagataatt atttaaaatt tgtcaatcat atatgcgatt taatttctat gaaaatagaa
    80881 gaacatgaag cgtcaaaaaa tagcagtaga aaaatggata tgatgataga aatcattgaa
    80941 aatgttgaaa aaggcgttat aatactagac ataaatagca aaatatctta tataaacaat
    81001 atagctctaa aaaaattaga tatagataaa aatataatag aaaatatagt aaatatagta
    81061 tctgttgaat cttcctcaaa tggacatgaa ttactagaaa ttgatattga taacaaaatt
    81121 tataatataa atgccaaaat aattccggta tatccatata taaatcaata cgacaaaata
    81181 ataatatttg acaagacata tatcaatcat aaaggacatg gaaaagtgaa tagtggctgg
    81241 ggaaatagtg atatagagtc tataattgga aattcagaag caatgttaaa agtaaaagag
    81301 agaactaaga aattagcaaa gtcaaattca actgtactta taactgggga aagtggtacg
    81361 ggtaaagagc taattgctag ggctatacat gctgaaggta gcagatggaa caagccattt
    81421 attgcgataa actgtgctgc tattccagaa aatctccttg aaagtgagct atttggctat
    81481 ataaaaggtg catttagtgg agctagtagt ggagggaaag taggtaaatt tgaacttgca
    81541 aatgaaggtg ttatatttct tgatgaaata ggagatttgt caatgccttt acaagcaaag
    81601 ttacttagag ttttacaaga gagaaaattt gcgagaattg ggtcaaataa acttatagat
    81661 ttagatataa gagtgattgc tgctacaaat aaaaacttat tgaaattagt aaatgaaggt
    81721 aagtttaggg atgatttata ctatagattg aatgtaattc ctataaattt gccacctctt
    81781 agggaaagaa aggatgatat tgaggcaata atgatgaagt ttgcttctaa atattcttta
    81841 gaattaggta ttcagttaaa taaaatagaa gaaaatgtaa tgaatatgtt gattaactat
    81901 aattggccgg gaaatataag ggaactggaa aatgcagttg aatatatgat gaatttggtt
    81961 ggagatgatg gaataatata taaagatatg cttccattag atattttaaa ctattataat
    82021 attaatggaa atatttataa aaataaggat gtaaatataa tatttgaaga tgatatagtt
    82081 ggagggatag tagagaatca agaaaggata ctttcaatta aagaattaga gttgacttac
    82141 ataaacaagt tgttgaataa gtatggaaga gatacaaaga cgaagaagaa gatagcaaaa
    82201 gacttaggca taggtttggc tacactatat agaaaattgg aagaggaaca gtagtaatat
    82261 aatattaaaa tgataggtat ttgtgtgttt ttatagatag gtatttttac tttatggtgg
    82321 aggtgttatt atgcaatatg cgatagagct atattatgat aaaaaaacgg aaaagcaact
    82381 ttttgattta tctaaaaaaa tcgctgatga aaaaattagt acgaagtact tagaatggaa
    82441 aacaagacct catcttactt tggcttgttt caatgatgtg gatgaggctt gttgcataga
    82501 caagctaaag gggtttgcac aaaaccataa ggtaatacct gcttacattg gttcagtagg
    82561 catgtttaat gatactaaaa cggtgtttgt atcacctata atgaatagca atgtatcagt
    82621 ttcagagaga attatatgag gtactacaag attttgattc aaatggttgg gaatggtacc
    82681 accccaatcg ttgggtaccc cattgcacaa tagcacttac tggagatgat gaaagtgagg
    82741 ctttttttcg ggcaagtgat gtattactgc gtgagttcaa aaaaataagt ggtgagtttg
    82801 tctcaatagg attggttaaa attacatttc ctgtggaaga aatttttaca gtgaatatga
    82861 ataggtaact ttaactctgt tgtggatgtt atgaatattt tgtatagtgc atttcatcag
    82921 ataaatgcga agttgcgaat ttcgacagct caatagtcgc aagtagggca caatggtaca
    82981 catattgcac ttttgcttat tggggggacg accatgtaaa cttctgtaag aagctatgaa
    83041 aagatttaag ccattttgga ggctttgggt aataaagaat atttgggtaa taaagtatat
    83101 aaatttatag agtttatgcg taagaaggtt atagccatat atttatagaa aataaaagta
    83161 gtaatatatc tgacaaaaca atagacatat aaaaaataag agcataataa aggaagaatt
    83221 aagataaata aacgatttct cgaattgata attctcgtat tgataaaaat ttcccaatat
    83281 gagaattttt tcttttataa atcttatttt tcacactcaa aatttataaa ctttaaagaa
    83341 attttataaa agtatgtaat tccaacataa aaaaattgtt tttagaataa ataatattgg
    83401 cacggtaatt gctttgctat aaggcacaaa gataaaaaat taaaatgaca ccgaaaaatt
    83461 tgaaagggga atataaaata aatgagagaa ataaaatgga aattaaataa cttacctaaa
    83521 tcagaggaaa aagaaaaagg aattgaattt ttaaaagatg aagagattgc aaaggctaaa
    83581 gcttttcatg aaagctttcc acaatatgaa aagactcctt tagttaaatt agataactta
    83641 gcaaaatcac taggcgtaag cggaatatat gttaaagacg aatcttatag atttggctta
    83701 aacgcattta aagttttagg tggttcttac tctatgggta gatacttagc tcaaagatta
    83761 aatacagata tatctgagtt agggtatgac aaattgactt cgaaagaaat aaaagaaaaa
    83821 ttaggagaaa taactttctt tacagctaca gatggaaatc acggtagagg agttgcttgg
    83881 acagctaata aattaggtca aaaatctgtt gtattaatgc caaaaggttc ttctgaattt
    83941 agattaaata aaatcaaagg agaaggtgca gatgctagta taacagactt aaactatgat
    84001 gatgcagtaa gattagctaa tgattatgca gaagctgatg accatggagt aatggttcaa
    84061 gatacagcat gggacggata tgaagaaata ccagcatgga taatgcaagg atatggaact
    84121 atggctaaag aagctataga acaattaaaa gaatatggag tagatagacc aacacacgta
    84181 tttgttcaag caggagttgg ttcacttgct ggtgcagttc aagggtatgt tgcttcaata
    84241 tatgatgaat gcccaataac agtagtagta gaggctgatg aggctgattg ttactataaa
    84301 tcagcagaag ctggagatgg aaaaccaaga tttgttggag gagatatgcc aactataatg
    84361 gcagggcttg cttgtggaga accaaacact ataggttttg aagtgttaaa aaattattca
    84421 tcagcattcg tttcagcacc agactgggta tctgctaaag gtatgagaat attaggaaac
    84481 cctctaagag gagatgagaa agtaatctct ggagaatctg gagcagttac aactggagca
    84541 ttagtttcaa tccttgaaag tgaagattta aaagacttaa gagaagcttt gaaactagat
    84601 gagaactcta aagtattatt aataagtaca gaaggagata ctgaccctga taaatataga
    84661 gatatagttt ggaatggtga atgccaaagt aaataaaaga cttaaggaaa ataaaaactt
    84721 aacaaataaa tgaaaaattt aaggaaaata aaaacttaaa taagtgaaaa ctttaaataa
    84781 aataaaaact aaaacaaatg aaaaatctaa ataaatgaaa aagtaaagca aatgaaaaat
    84841 tcaaaataaa aactaaataa aattaaataa aaccaaataa aattaaaata aagtctaaat
    84901 aaaaatttaa taaataaaat ataaagaaat aaaaaatcaa tagattaagt gaaatgctaa
    84961 taaattaaaa aagtgaaata tcaaaataaa acgtcaacaa actaaaaatt atatggggga
    85021 atatcaaaat gttaaatgaa acaagaaaaa aacaattaac tgaagtatgc caagacttaa
    85081 taagaaatgc tagttattca ggtcaagaag aaaacgtagt aaaagctata gaagaaaatt
    85141 ttgctttact aggttttgat agttggtcaa gagatagata tggaaatata gtaggatgta
    85201 taaaaggaaa taaaccaggt aaaaaaatat tatttgacgg gcatatagat acagttccag
    85261 ttccagatgc aagtaaatgg agtgttcctc cttttgaagc gagaatagta gatgggaaaa
    85321 tatatggtag aggaacttct gatatgaagg ggcaagtaag tgctatgatg gctgctgttt
    85381 catactttgc agaagatact aacaaagact ttgaaggtga attgtatgta gcaggtgttg
    85441 ttcatgaaga aatatttgaa ggtgtttcag ctagagagat aagtaaggct gttcaacctg
    85501 attatgttgt aataggtgaa tcttcagaat taaacttaaa gataggtcaa agaggtagag
    85561 gagaaatagt agtagaaact tttggtaaac cagctcactc tgctaatcca gaaaaaggta
    85621 taaatgcagt ttataaaatg gctaatgtaa tccaaaagat acaacaatta gtacctccaa
    85681 ctcatccagt tttaggtgat ggaatattag ttttaacaga tataaaatct tctccatatc
    85741 caggagcatc agtagtgcca gattattgca aagctacttt tgatagaaga ttattagttg
    85801 gagaaacaag agaaggcgta ttagctccaa tacaagcttt attagatgaa atgatgaaag
    85861 aagacccaga attaaatgca aaagtttctt atgcagttga aaaagctgat tgctatacag
    85921 gaaatactat agaaagtgaa agattcttcc caggttggtt atatgatgaa gaagatgaat
    85981 ttgttcaagc agcgtataag ggattaaaag aagctggaat agattcagaa ataactcaat
    86041 actcattctg tacgaatgga agtcactacg caggtgaggc tggaataaga actataggat
    86101 ttggtccttc taaggaaaat cttgctcata caatagatga gtatatagaa ttagaccaat
    86161 tattcaaagg tgcagaagga tattatggta tattaaaatc agtttataaa aaataattag
    86221 gagatggttt tgtgagaact ttaataaaac atgggcttat agtagatgga aataaaacac
    86281 cagcatatga aggagatatt ttaatagaaa acgagaaaat attaaaaata tcacaagatt
    86341 taaacgaaga agctgacaaa gttatagatg caaaaggtag agttatatgt ccaggtttca
    86401 tagatactca tagccattca gacctagtta ttttagttaa tccatataat gaggtaaaga
    86461 ttagacaggg aattacaaca gaagtgttgg gccaagatgg tatatctatg gcccctctac
    86521 ctcaagagca tatatcttct tggagaaaaa atttagcagg tctagatggt gaaagtgatg
    86581 aaattgattg gaaatatgaa acaacagaga attatttaaa aatgatggat tacaatgggg
    86641 taggtttaaa tgaaacttat ttagtacctc atggaaacgt tagaatggaa gctatgggac
    86701 ttgaagatag acctgctact aaagaagaaa ttcaaaaaat gtgtgaaatc acagagagag
    86761 aattaaaagc aggagctata ggattgtcta ctggacttat atatatacct tgtgcatact
    86821 cattgactga agaaattata gagatgtgta aggtagtagc aaaatatgac ggagtatttg
    86881 tagttcacca aagaagtgaa gcagatacaa ttttaacttc aatggaagaa atcatagaaa
    86941 ttggaaaaca atcaggagta aaagttcatt tttcacattt taaggtttgt ggtaaagcaa
    87001 actggaagta tataccacaa gttatagagc ttttagaaaa agcagaaaag gaaggaataa
    87061 gagtatcttt tgaccaatat ccatatgcag caggaagtac aatgcttgga gtagttttac
    87121 ctccttgggc acattctgga ggaactgata agttaataga aagattaagt gatgaaaacg
    87181 aaagagcaaa aatgaaaaaa gatatagcaa atggaataga aggctgggat aattttatag
    87241 aatttgctgg aatagaccaa atatttgtaa caagcgtaaa aacagaaaag aataaagata
    87301 caattggtaa gagcttatta gaaattggaa aaatgagagg aaaagaccca ttagatgcaa
    87361 cgtttgattt attaaaagaa gaagaaaatg cagttgggat ggtagatttc tatggattag
    87421 aagaacatat aataggattc atgaaaagag acgagcaaaa tgtgtgtaca gatggtcttt
    87481 tagcaggtaa accacatcca agagcttatg gttctttccc taaaatacta ggaagatatg
    87541 ttagagagtt gaatgtgtta acaatcgaag aagctgttta taaaatgact aaaaaggcag
    87601 ctacaagctt tagtataaaa gatagaggcg aattaaaaga aggatatttt gcagatatag
    87661 ttatatttga caaggataca gttagtggtt gtgatgattt tatcaactct atgcagtacc
    87721 ctacaggtat agattacgta attataaatg gaaattgtgt tgttgaagaa ggaaaataca
    87781 ataaaattaa agcaggaaaa gtacttaaaa attaaatctt agctttaagg aggaataaat
    87841 ttatgatttt agtggggaat gggaggctaa taagccaaga ttctttaaat ccctatatgg
    87901 aagatggatg tgtagtaata aatgataatc taattgaaga tataggtact acagaagaaa
    87961 tgaaagctaa atatccagta catgaattta tagatgcagg caagaaaata atcatgccgg
    88021 gtctaataaa ttcacatatg catatataca gctcatttgc tagaggaatg gcagttccag
    88081 gaaaaccttc tgagaacttt ttagagatac taaataattt atggtggaga cttgacaaac
    88141 agcttacact ggaagataca aaatacagtg catatgcaac gtatatagaa tgtataaaaa
    88201 atggtgtaac aacagtttat gaccatcatg caagtccaaa tgcaattgaa ggcagtttgt
    88261 ttacaatatc agatgttgca aaggatttgg gaattagaac gtgtctttgt tatgaagtgt
    88321 ctgatagaga tggtggaaat acaatccaac aaggtatcaa tgaaaacgta aactttataa
    88381 aatacgctca aaaagatgat acagacatga taaaaggaat gtttgggctt catgctgcat
    88441 ttacactatc tgatgataca ttaaataaat gtgcttcaga gatggctggt cttgatacag
    88501 gttaccatgt acatgttgct gaaggactag cagacttaca atataatgta gataaatatg
    88561 gaaaaagggt tttagaaaga ttcaatgatt ttggagtact aaaagaaaaa acaatagcag
    88621 ttcattgtat atatataagt gcagaagaaa tcagtctttt aaataaaaca aatacatttg
    88681 tagttcataa tccagaatct aatatgggaa atgcagttgg atgttctcct gcaatagagt
    88741 tattaaaaag gggagttaca gtaggattag gaactgatgg atatactagc gatatgtttg
    88801 aatcattaaa agttgccaat ataattcaca aacatcactt aaaagaccca agagttggat
    88861 ttgaagaatc acaaacaatg ttatttgata acaatagaaa aatagctaaa gcttattata
    88921 aaaatgacct aggagtactt aaaaaaggtg cttatgcaga tgttatagta gttgattata
    88981 taccacatac tccattgaca gaaaatacaa tagggggaca cactattttt ggaatgagtg
    89041 gaagaagcgt agatacaact attataaatg gaaaggtact tatgaaagat agaaagttaa
    89101 taaacataga tgaagaaagt attttagcaa aaagtagaga attaagtcaa aatctatgga
    89161 atagaattta aataattgat attaatatac aagtaagaaa caagaattta gatgttaaaa
    89221 acagagctta aacaaaaata ggaatttaaa tgaagtatat aaataaaaaa tatacggaat
    89281 agaatattaa attaaatata gaagggagac ccaaaatgtc tcgagataaa agccctaaaa
    89341 tagctccagt agatgaaagg ttacctgtat ccaaatcttg ggtattttca ctacagcacg
    89401 ttttagcaat gtgtgcagga gcagtagcag ttcctatgat gataggaagt gctgcacgac
    89461 tagatcatgc tagtattgtt tttttaataa atgcttgctt gtttatggca ggtataggaa
    89521 cactcataca aagtgttggt ataggaaata ttgtaggtgc taaaatacca gtaatagaag
    89581 gaactagttt tgccgctgtg gcaggtatga cagcaatagc ctcatcatat agtgattcac
    89641 aagttgcaat acagacagta tttggctctg taatagtagc tggattgttt tgtatattac
    89701 ttgctccagt atttgaaaaa ttaataagat ttttccctag tgtggttact ggaacagttg
    89761 ttatggtaat aggtatttca ctatttccag ttgggataaa atggataact gacaacaaat
    89821 tggaagcggt tgaaccaaac tcattagcat tagctttagc agtattggca ataactttac
    89881 tttcatttaa attcttaaaa ggaatttgga atagtacagc tatattggta ggtatagtac
    89941 ttggtacact actttccatg gcagttggaa tggcagattt tagtgcagta aatggagttg
    90001 gttggcttaa cttaaatgta cctttaaaat ttggaatgcc tagatttgaa ccatctgcaa
    90061 tactatcatt gtgtttgatt atgttggtac ttatgacgga atcagttggt aatatgatag
    90121 ctattcatga aatggtagac aaagaagtaa caggtaaaaa tattaaaaga ggtctatttg
    90181 gagatggaat atctacagca ttatctggaa tattcaattc atttccaata actccatttg
    90241 gtcaaaatac aggaatagta ggtcttacag gtataaaatc aagatttata gcagtttacg
    90301 caggggttat attgctagta cttggattct taccaaaatt tgcagcaata ataggagcaa
    90361 tacctaagcc tgttcttgga ggcgtaggat ttgcaatgtt tggaatggta atggttggag
    90421 gagtaaaaac tttaagcaaa gtgaaatttg atggaactaa aaatggggtt atagtagcag
    90481 ttagtgttgg tttgtctatg ataccactaa caaatcctga tttctatcat aatttcccaa
    90541 cttgggtaca aacaatattc catagtggaa taacaacagg tagtttatca gcagtgcttt
    90601 taaacatatt cttcaatgaa ctaggttcta aaaaagaaaa aaataataaa gttgaagaag
    90661 caaaataaaa ataaaacaag taaaaatcta tattgactta aagtcattaa gcattaataa
    90721 aaataattca gagatattaa taattcaaca aaactatctt atattttaaa taatataaaa
    90781 aagtaaataa ataacgaata caaataaaag aatacaatct aaatattaaa aatatttaat
    90841 ttaagggaga gataataata tggctaattt aaaagttaat ttatatggaa tggaattttt
    90901 aaacccaatt atgacagcgg caggacctgg agcaaaagat ggtgctctct gtcaagaggc
    90961 agcaaaaggt ggagcaggag ctatatgtac aaaaactata tctgtattac cagctgatgt
    91021 accaagacca tgtatggcaa aaactaatag tggtttttta aacacagaat tatggtcaga
    91081 gcttccaaaa gagcaatgga tagaggaaga atacaaaaag gtaaaagaaa cagggcttcc
    91141 agtaatagta agtatgggat attcagcaga gcaaatagct gaggttgctc ctttagtaaa
    91201 gccttatgca gatgcagttg aattatctac tcattatgta ggtacagacg ttgcaccaat
    91261 agtaaatgct ttaaaagctg caaaagctgt tttagatgta ccagtattta tgaaaatgag
    91321 tcctcatact gacattcaaa ctattgcaaa agctgttgaa gaagcaggtg cagatggact
    91381 tgtaatgata aactcatttg gaccatgtat ggcaatagat gtaaatacag gataccctat
    91441 aatgggaagt aaagctggat acggatggtt atcaggtgca ccaataagac ctctagcaat
    91501 aagatgtata tatgaagctt ctcaagttgt aaatatacca ataatcggtg ttggtggaat
    91561 cacttgtgga aaagacgtgg ctgaaatgat gatggctgga gcaagtgctg ttcaagtatg
    91621 tacagaagca atccttaaag ggccttctat ctatggaaaa attgctaaag aattaaatga
    91681 atttttagat gagaatggat atgctgatgt taatgaaata aaaggattaa ctcataagaa
    91741 aatggcagct agagggttta gaactcattc agtagctcca gtagtggatg ataacaagtg
    91801 tatcaaatgt aagcaatgtg taacaagctg tgtatacgaa gctttagaag ttacagataa
    91861 gttgaacata gatgcagaca agtgttttgg atgtggatta tgtgtaacta gatgtccaaa
    91921 aggagcttta agcatctgct acaatcaagt agaagctatg aatgagtaat aattatatag
    91981 aattttggta attaacttag agtaataggt attaggataa taaaatatat cagataaaca
    92041 aacacgcatt atgcattaat aatacagtct aaagttaata attttattat attgatttaa
    92101 ctaaatatta gtttagctga atattaattt aattaggtat tggtttaatc ttaatataga
    92161 tttactacgt ataagtgaac taactagatt actttaagtt aattttttca tataaaataa
    92221 attgatacat tacaagtaag gtggagtcta tatgggaatt gttttaaaag gtgggaaagt
    92281 agtaacaagt gaaaaaactt actgtgcaga tgtaagaata gaagatgaaa aaatagtcga
    92341 tataggtctt gatatatcaa aagaaaatga tgaaatagtt gatgttagtg attcttatgt
    92401 tataccagga ggtatagata cacacacaca ctttgactta gatacaggcg ttactaagac
    92461 agcagataac tttgagacag gaacaaaagc tgctatagta ggaggaacta ctactatatt
    92521 ggattttgct acacaagcta aaggatgttc tttgaaagac ggattagaag aatggcatga
    92581 aaaagctaag gataaatcat attcagatta tggctttcat atggctataa cagattggaa
    92641 tgactcggtt tgtaatgaaa tggaggatat ggtgaaagag ggagtatctt catttaaact
    92701 gtatatggcg tataaaggaa gccttcaagt tgatgatggt gtaatctttg aagcattgag
    92761 aaaagcagaa gagataggag ggattattgg tttccattgt gaaaatgggg acataatatg
    92821 tgaacttgtg gataaagcaa agtcagaaaa taatttatct ccaaaatatc atcaattaac
    92881 tagaccagct ataatggagg cagaagctac atcaagactt atgaagatag ctgaagttgc
    92941 aaactctaaa gtatatgtag ttcacttaag ctgtaaagaa tccttagagg aggttttaaa
    93001 agctaagcaa agaggtgtgg atgtaatagt tgaaacttgt cctcaatacc ttctattaaa
    93061 tgatgaatta tatgatttag atggatttga aagtgctaag tatgtaatgt caccaccttt
    93121 aagaaataaa gaaaataatg aaatattatg gaatgctatt ttagataatc aaatagacac
    93181 tataggaaca gaccattgtt cttttaatta taagggacag aaggaacttg ggataaacga
    93241 tttcagtaag ataccaaatg gttctccagg tgtagaacat aggatgagtc ttttatacac
    93301 atatggagtc tgtaaaaata aaatatctat caacaagatg gtagaagtaa catcaactaa
    93361 tgcagcaaag ttgtttggaa tgtatcctaa taaaggaact atagaaatag gcagtgatgc
    93421 agatatatta gtcttaaatc caaacaaaaa atccaaaata gaagcaaaaa aacaattaca
    93481 aaatgtagat tatacacctt atgaagggta tgaagtggat tgtcaaatag aacatgttta
    93541 tttaagagga aaagaagtag ttagagatgg agaattaatt tgtaatactc caagtgggag
    93601 atatataaat aggcgtctaa caaagggggc tagagaatgg tagaatttat attaaatgga
    93661 gagaaagttg ttgcaaaaga aggcaaaaaa cttttagact tccttagaga agatatgaat
    93721 ataacttcag ttaaaaatgg atgttcagaa ggtgcttgtg gaacatgtat ggttataata
    93781 gatggtaaag ctactaaagc atgtgtattt aaaactgata aattagctgg gaaaaacata
    93841 acaactatag agggattatc agagagagaa agagatgttt ttgcatattc ttttgctagt
    93901 caaggagctg tacaatgtgg attttgtatt ccaggtatgg taattagttc aaaagcactt
    93961 atagacgtta ataataatcc tactgaagat gatataaaga aagctttaaa aggtaatata
    94021 tgtagatgta cagggtatgt aaaaataatt aaagctgtcg atttagcagc aaagattttt
    94081 agagaaaata tagatgtgcc aaaagtaaac tgtaaaggtc tagtaggtga aaatcttcct
    94141 agagttgatg cagttggcaa agcacttgga tattctgaat atgtagatga tatgagaatt
    94201 gaaggtatga tttatggttc agcagttaga gctaagtatc ctagagcttt agttaaaaaa
    94261 atagatatag aagaagcaaa agcttatcca ggagttgttg cagttctaac agctaaagat
    94321 attccaggaa ctataaaggt agggcactta aagaaggatt gggatacttt aataccagaa
    94381 ggtgaaataa ctagatactt aggagatgga atagttttag tagcagcaga aactagagaa
    94441 gcgttagaag aggcaaaaaa gctagttaag atagattatg aggaattaac accattaagt
    94501 actacagaag atgcgcttag agaagatgct ccaaagatac acgagacagg taatatactt
    94561 gttaaggaac atttagtaag aggaaacgct aaagaaaaga tagaaaattc aaaatatgtt
    94621 gtaactaaaa gatatactac acctgctaca gaacacgcat ttttagagcc tgaatgtgca
    94681 gtagctggtc cttatgaaga ggatggagta ataatctatt caacagacca aggggtgttt
    94741 gccactcaac atgaatgtgc agatatgtta gggctaccat atgagaaggt aagagttata
    94801 aacaaaatgg taggaggagg atttggtgga aaagaagaca tgagtgttca acaccatgca
    94861 gccttacttg cataccatac taagagattt gtaaaagtac agttaacaag aaaagaaagt
    94921 attattgttc atccaaaacg acatgccaca gaaatggaat ttacgacagc atgtgatgaa
    94981 aatggatact taacaggtat gaaggcaacg ataatatctg acacaggtgc atatgcctct
    95041 cttggaggac cagtgctaca aagactgtgt actcatgcag caggaccata taattatcaa
    95101 gatattgata taacaggaac agcagtatat actaataacc ctcctggagg agcatttaga
    95161 ggatttggag ttacacagag ttgttttgca actgaatgta atctaaattt acttgctgaa
    95221 atggttggaa tatctccttg ggagataaga tataaaaatg caataagacc tgggcaagtt
    95281 ttaccaaatg gtcaatttgc agatgaagga acagcaatgg cagagacact agaagctgta
    95341 aaagaagagt atgaaaagca tccacgtgca ggtatagctt gtgctatgaa aaatagtggg
    95401 gttggagttg gtatacctga tgttggaaga tgtagattgg tgataaaaga tggcaaagtc
    95461 cacataagaa caagcgcttc ttgtataggt caagggcttg gtactgttat gactcaagta
    95521 gtttgtgaaa ctgctagcct acttcctgaa aatgtagtgc atgaagttcc agatactcat
    95581 ttaacaccag actctggtaa tactacggct tcaagacaga cagtatttac gggagaagct
    95641 actaaggttg cgtcaaataa gttaaaagaa gctttagact ctggcaaaac tttacttgat
    95701 ttagagggag aagagtttta tggagaatat gaaagtatta cagataaaat gggttgtgac
    95761 aaagaaaatc cagtaagtca tgttgcttat ggatatgcaa cacaagttgt aattctggat
    95821 gaaaatggaa aattggaaaa agtagtagca gcacatgatg ttggaagagc tataaatcca
    95881 atcagtttag agggtcaaat agaaggtgga gtagttatgg gtcttggata tgctctaacc
    95941 gaagattacc cagtagttaa ctctgttcct acagctaagt ttggtacatt aggtttattt
    96001 aaatctacag atataccaga aatacaagct ttaatagttg aaaagaacaa agatttattg
    96061 gcttatgggg caaaaggtgt aggagaaatt tgtacagttc ctactgcacc agcagtacaa
    96121 aatgcctatt atgtatttga taaagaattt agaactgaac taccactaca aaatactcca
    96181 tatagtaaaa aaaagtaaca aaaaaaagaa atattaaata aaaaaataga tgaaattgta
    96241 aataaaaaaa tagatgaaat tgtaaataaa aaaatagatg aaattgtaaa taaaaaaata
    96301 gatgaaattg taaataaaaa aatagatgaa attgtaaata aaaaaaaccc ttttgcataa
    96361 ggtatatttt aaatgataga atatacatat acaggagggt ttttctttta taaaataagt
    96421 ttaataaaat tgagaggtga gcagaatgaa ttttaataat agtctagaat taactcagtc
    96481 tcagaagcta ataatgacta cacaacttaa gcaatcatta tcaatattaa atatgagtaa
    96541 gttagagtta gaagaagaga taaaaagaga agcagagaat aacccattag ttgaagtcga
    96601 gaaaagtggg gagataaatt gggaagagta tataaaagac atggataggt caagacgttt
    96661 agatagaaca gagataagct ataatcctga taatgaagtt aatctagaaa atttagttaa
    96721 atattcgtca aatttatatg aagatttaaa atttcagata agcctgtata aacttacaga
    96781 caaagaattg gaagtctgtg agtatataat tgatagttta gatgaggatg gatatttaag
    96841 aactgaggaa aaagtaattg ttgatacctt aaagatagat gaagaacttt ttgaaaaatg
    96901 tttaattagt gttcagcagt tggaacctag tggagtaggg gcaagaagtc tttcagaatg
    96961 tctgatgata caaatggcta gtttaggaat atataatgaa attttagagg aaatcgttac
    97021 aaaagactta aatttaattg caaataataa atacaaagag ataagtaaaa agtacaatat
    97081 gtcattacaa aaatgtgttg aactaataaa cataattaag acattagacc caaaaccagg
    97141 aagaacttgt tcagtagaga aaagtgtata cattcaacct gatgtaacag tagaaaaaat
    97201 tgatgatgaa tttattgtat atttaaatga aaaagattct tatcaaataa gaatcaatag
    97261 ttattataaa gacatattaa aaaattcaca gtctgatgaa agtgcaaaag aatttataaa
    97321 agaaagacta aattcagcaa caggacttat gaaaaatata gagagtagga aaactacagt
    97381 acttaagatt gcagaagaga tagtaaaagc tcaagatgaa tttttgagaa aagggacaaa
    97441 atatataaaa cctttgaaaa tgaaagacat agcagaaaaa ttagaatttc atgaatctac
    97501 tataagtaga ggtgtaaatg gtaaatatat gttaacacct tttggtgtat atgaatttag
    97561 atactttttc agtagtgcca ttgagactga gaataatgaa atggcatcta gtacaagcat
    97621 aaaaaaaatt ataaaggaaa caataaaaga cgaaaataaa aagaaacctt taagtgatga
    97681 ccatatatct aagttactaa aagaaaaagg aatcaatgtt gcaagaagaa cagttgccaa
    97741 atatcgtgaa gaattaggaa tcccatcttc aagtaagaga aaagaatact aataagtaaa
    97801 agacaaatat cagtatggta aggggaaaag gctaattaaa agatgaatgt agattgggct
    97861 aaaaatttta tgaagtaaaa taatagaata tggaaaagta ttaaaatgct ataagatatt
    97921 aaaaaactgg ggaacattaa aacattaaga tagcaaagaa cataaaaaac taaagaagat
    97981 taaaacatta aagaacatta gagctttgag gaatattaga actttaaaga atattaaaat
    98041 ttataaaata taaaaatact aaaaagaatt gaaaaactgg ggaacattaa aatattgtaa
    98101 aatgctaaaa aactagaaaa cataattaaa taagtgctta taaagaatga ttaaattaaa
    98161 taagtgtttg taaagaataa ttagatatta gaaaaagaag aatacctaga taaataaact
    98221 attattaaat ttaataatca taaaaggaaa acacagggta taaataaaaa tcttaactag
    98281 ataaaagtaa acttagttgt agataaaaat aactagaaat aaaagtaact agaaataaaa
    98341 ttatttatag taataaatat tagaatgaaa atataaaaaa atatatataa aaagccttat
    98401 ataaaaagaa aaaatactgt gatttgaaaa tggtggagaa atattttata aaataaaaaa
    98461 ataaaaaagt ttttgaaaaa ctattgaaat ctatacgcaa atcctataaa ataaaaatat
    98521 cttgtgggac ttaaataaac actagggacg aaaaaagtcc cgaaaggaaa gcaataagga
    98581 gtatgttatg aagaacttat tagaaattca aaagaaattg attccacagg caattgaact
    98641 tatggaaaga agatactcta ttttaagaca aatatcttta agtgaaccaa taggtaggag
    98701 aacattatca aatgtattag agattagtga aagaataatc aggtcagaaa ctgagttttt
    98761 aaaagaacaa ggacttatag acgtagctgt atccgggatg actatcacta aagaaggttc
    98821 tgatttgtta gataaactta aggacatcat gagtgacatc atgggattgt ctaagttaca
    98881 agatagagtc agagaaaagc ttggaataaa aagggtaata ttagttcctg gaagctgtga
    98941 tgaaaatgga agtttactaa aagatgtaac tagatatgga tgcgagtatt tcttaggtat
    99001 tttaaaagat ggagatatcg tttcaataac aggaggaagc actatgttgg agttttcaaa
    99061 cgttattaaa actgataaga gatacccaaa ctctacaata gttccagcta gaggaagtat
    99121 gggaactgat gtagagatgc aatctaataa tatagttgct tcgataagta agaaattaca
    99181 ttctaattgc aaacttttac atataccaga tgagttggat gaaagtgcaa tgaaaactct
    99241 tagccaagtg ccagagatta agacaacttt ggagtatatt aaaagaacag acattttagt
    99301 ttttagtata ggtagagcag atgtcatggc aaagagaaga aaacttccag aagacaaggt
    99361 tgatgagata ttatctaaaa atgcagttgg agaagcattt ggatattatt tcaacaaaga
    99421 tggagaaata gtttacaaac tgaacactgt tggaattgat ttagaaacag ttaaacaagt
    99481 aaaagaaact attgcaatct ttgcaggtac tgaaaaagta gaagccttat tagctatatc
    99541 aaatatgcat aaaaacatgg ttcttgtaac agatgaagaa agtgcttata agatattgtc
    99601 attattataa aagtcaagac ctagcacaga gctagaaaac atacatttac tttataggag
    99661 gtagcgaaaa tggttaaagt agctataaat ggatttggaa gaataggaag attagcatta
    99721 agaaaaatga tggagcaaca agataagttc gaagttgttg caataaacga cttaacagac
    99781 gctaaaatgt tagctcattt atttaaatat gatacagctc aaggaagatt taacggagaa
    99841 atagaagtta aagaaggtgc ttttgtagta aacggaaaag aaataaaagt aacagcagaa
    99901 agaaatcctg ctgacctacc atgggctgaa ttaggagtag atatagtatt agaatgtaca
    99961 ggattcttta catctaaaga taaagctgaa gctcatatac aagcaggggc taagaaagtt
   100021 gttatatctg caccagctac tggagattta aaaacaatag tattcaacac aaacagtgat
   100081 atattagatg gttctgaaac agttatatca ggagcttctt gtactactaa ctgtttagct
   100141 ccaatggcta aagtattaaa tgataaatac ggtatagaaa aaggattaat gactactata
   100201 catgcataca ctaatgacca aaatacttta gatggtcctc atccaaaagg tgatttaaga
   100261 agagctagag ctgctgctgg aaacatagtt ccaaacacta caggagctgc aaaagcaata
   100321 ggcttagtaa taccttcatt aaaaggaaaa ttagatgggg cagcacaaag agtaccagtt
   100381 gtaactggtt caataactga attagtttgt acattaggaa aaaatgttac agttgaagaa
   100441 ataaatgcag ctatgaaaga agcttcaaac gaatctttcg gatatactga agaaatgtta
   100501 gtatcttctg acataatcgg aataagctat ggttcattat ttgacgctac tcaaacaaaa
   100561 gttatggaag tagatggaaa acaattagtt aaagttgttt cttggtatga taatgaaatg
   100621 tcttatactt ctcaattaat aagaacttta ggatactttg cacaattagc aaaatagtca
   100681 gttttgagaa aatagaaaag tagattgaca aagtccgagt ttgtagttta atactacgga
   100741 ctcaggactt tttttaagaa aaaatatata aaatacacct aaataatgtt acatactata
   100801 tataaaaata tgataatatg atatatttaa tagggtaaaa gtatgtacta tattatactt
   100861 ggcaataaaa aattacttta ttaaaaggag agatatttat gtcaatgctt aacaaaaaaa
   100921 ctatagaaga tattgatgtg tgcggaaaaa aagtattagt aagatgtgac tttaatgtgc
   100981 cattacaaga tggtgtaatt actgatgaaa atagattgaa cggagcttta ccaactattc
   101041 aatatttaat ttctaaaggt gcgaaagtta tattatgctc tcacttagga aagccaaaag
   101101 gagaagctaa gccagaatta tctttagcac cagtagcaaa gagattatct gagatgttag
   101161 gaaaagaagt tgtatttgca gcagacgata atgttgtagg agaaaatgca aagaaagcaa
   101221 ctgaaaaaat ggaaaacgga gatgtagtat tattagaaaa tactagatat agaaaagaag
   101281 aaactaaaaa cgaagagaat ttctctaaag aattagcatc acttgctgaa atatttgtaa
   101341 atgatgcgtt tggaactgct catagagcac attgctcaac agttggtgca ggtgagttct
   101401 tacaagagag agtttgtgga tacttaattc aaaaagaatt aaaattctta ggagaagctg
   101461 ttgcaaaccc tgtaagacca tttacagcta tacttggagg agctaaagtt tctgataaat
   101521 tagctgttat aaacgaatta ttagaaaaag ttgataatct aataataggt ggaggaatgg
   101581 cttatacatt cttaaaagct cagggttatg aagtaggaac ttctttactt gaaatagata
   101641 aagttgaata tgctaaagaa atgatggaaa aagctaagaa taagggtgtt aacttattat
   101701 taccagtaga cgttgttatg gcagaccact ttgcaccaga tgctactcca atagtaacag
   101761 aagatgctaa tgtaaaagaa gattacatgg gactagatat gggacctaag actatagcaa
   101821 actttgtaaa aactataaaa gaatcaaaaa ctgtagtatg gaatgggcca atgggagtat
   101881 ttgaatttga aaactttgca aatggtacat tatcagtagc tagagctatg gcagagttga
   101941 ctgatgcaac tactgtaatt ggcggtggag atagtgcagc agcagttaat caattaggat
   102001 ttggtgacaa gatgactcac gtatcaacag gtggaggagc atcactagaa tttttagaag
   102061 gtaaagaatt accaggtatt gcagcattag ataataaata aactaatata tagaggagat
   102121 tgtaaaatga gaaaacctat aattgcagga aactggaaaa tgcataaaac aataaaagaa
   102181 gctttagaat ttgtaaatga agttaaagat aaagtaaatt ctgataaagt agaagctgtt
   102241 atatgtgcac catttacttt attaaaggat ttaaaagaag ctactaaggg tacaaatata
   102301 aagataggtg ctcaaaatat gcactttgaa gaaaaaggag catttacagg agaagtttca
   102361 cctcttatgt taaaagaaat agatatggac tatgttgtaa taggacattc agaaagaaga
   102421 caatacttca atgaaactga tgaaactgta aacaagaaag ttttaaaagc attagaagta
   102481 ggaatagacc caatattatg tgttggagaa actttagaac aaagagaagc tggaaaaact
   102541 aaagatgttt gtaaagttca agttgaaaaa gctttagaaa atgttcttaa agatgattta
   102601 gcaaaagtag ttgttgcata tgagccaatc tgggctattg gaactggtaa aactgcaact
   102661 gctgaagatg ctaatgacgt tatatcttat ataagagaag ttataaaagg attatatgga
   102721 gaattagcta atgaagttag aatacaatac ggtggaagtg ttaaaccttc aaatgtagcc
   102781 gaaataatgg gtcaaagtga tatagatgga gctttagtag gtggagctag tttagctagt
   102841 aatgattacc tagaccttgt taatttctaa ggagtgaaat gatgaaaaaa ccagttgctt
   102901 taattattat ggacgggttt ggatacaata aggatgttaa gggaaatgca attgctgagt
   102961 ccaaaactcc taatttagat agaataaaaa aagagtatcc aaacacattg ataaatgcta
   103021 gtggtcttga tgttggtcta cctgatggtc aaatgggaaa ttcagaagtt ggacacacta
   103081 acataggtgc aggtagaata gtatatcaag atttaactag aataacaaaa tctataaaag
   103141 atggtgactt ttttactaat aaagttttat gtgaagcaat ggataatgca aaagaaaatt
   103201 ctcttcatgt aatgggactt ttgtctgatg gaggagtaca ttcacatata gaccatctta
   103261 aggctataat caaaatggca aaagataaag gcgtacaaaa ggtgtatgtt cacgcattta
   103321 ctgatggtag agatactgac cctcaaagtg cattagaata tgccaaagaa gtacaagcta
   103381 gtatggatga aattggagta ggtgaatttg ctacagtttc tggtagatac tacgctatgg
   103441 atagagataa gagatgggaa agagtagaac ttgcatacaa tgccatggtt agaggtattg
   103501 gtgaaaaagc aaattctatt gaggaagcta ttcaaaactc ttatgatgat ggaaaaaatg
   103561 atgagtttat aatgccaaca gttattatga aagatgataa accagttgga agtataaagg
   103621 aaaatgattc aattatattc ttcaacttta gaccagatag agctagacaa ataactagag
   103681 ctttagtttg tgaagagttt gatggattta aaagagaaga tattaaaaac ttctttgtat
   103741 gcttaacaga gtacgatata actatagaga atgtgcatat agcatttgga cctcaatctt
   103801 tagccaacac tctaggtgag tatctagcta aaaatggaaa aactcaactt agagctgctg
   103861 aaactgaaaa gtatgcacat gtaactttct tcttcaatgg tggagtagaa gagccaaata
   103921 aaggtgaaga aagactattg ataccttctc caaaggttgc aacttatgat ttaaaaccag
   103981 aaatgtcagc atatgaattg acagataaag ctttagataa attaggagaa gataagtttg
   104041 actttatagt attaaacttt gcaaatcctg atatggtagg tcatacagga agtatagaag
   104101 cggctataaa ggctgttgaa actgtagata cttgtgtagg aagattgata gataaaatag
   104161 tagagttagg tggaagtgca ataataactg ctgaccacgg aaatgctgaa tatatgttag
   104221 acccagaaac aggaaaaact gtaacggctc actctattaa tccagtacca tttattgtag
   104281 ttggtcaaga atatgaaagt gcaaaattat tggatggagg aagattatct gatatagcac
   104341 cgactgtttt agatatgatg aagttagaaa agccagaaga aatgactggt cattcactta
   104401 tttcaaaata gtcgattctg ataagtagag aataatatat aaactacaat ataaatttaa
   104461 aaataatgca gtttaggttt attttgtaaa gtttagactt tatgacagaa gatttagatt
   104521 ttgtaagttt tggatattgt aaggtgtaga tgaagatata ttttataaaa tttacaagat
   104581 agacaattta taaaataaaa aattataata tagataataa tgtaaataat gatataaata
   104641 ataacaagat agacaataac aatataaata ataataatta atatatatta tataagcaaa
   104701 aattttagaa tcattagttg tacattttat gtttaatgtt ttaaatctag ttataatatt
   104761 tgtgtattta agattggttt tggattttag acaagttttt ttatattata taaattaaaa
   104821 tattataaaa aataaaataa aaataggaac ttttacaaat ttacccatca aataaatttg
   104881 tacctaattt tcaaaagcaa ctttatgtac tataatatag aaagtagatt aaaatagtag
   104941 acggatgttt acagtaaatg aaaatttaac taatagaaaa tcgaagggag atatacaaat
   105001 gtcagttatt gaattagtat atgctagaga agtattagac tcaagaggaa atccaactgt
   105061 agaagttgaa gtagtattag aagatggagc aatgggaaga gcaatagttc catcaggagc
   105121 atctacagga gcttttgaag ctgttgaatt aagagatgga gataagggaa gatacttagg
   105181 aaaaggtgta gaaacagctg ttgctaacgt aaatgaaata atagcacctg aaatagaagg
   105241 aatggatgca tttgaccaac cagctataga tgcaatcatg atagaattag atggaactcc
   105301 aaacaaaggt aaattaggag ctaatgctat attaggtgtt tcaatggcag tagctagagc
   105361 agctgctgat gaaataggtt taccattatt ccaataccta ggtggagtaa atgctaaaca
   105421 attacctgtt ccaatgatga acatattaaa cggtggagag catgctgata acaacgttga
   105481 tgttcaagaa tttatgatat taccagtagg agcttgttgt ttcaaagaag gtttaagaat
   105541 gggagcagaa gtattccatt cgttaaagaa agttttagga gaaaaaggat tagcttgtgg
   105601 tgtaggtgac gaaggtggat ttgctccaaa cttaggttca aacagagaag ctttagaatt
   105661 aatagttgaa gctataacaa aagctggata taagccaggt gaagacgtta tgttaggtct
   105721 tgacgttgct gctacagaaa tgtacaacaa agaaactaaa aaatacgttt tagcaggaga
   105781 aggaaaagag ttaactgctg ctgaaatggt tgctttatat gaagattggt caaacaactt
   105841 cccaataata actatagaag atggtttaga cgaagaagat tgggatggat ggaaattatt
   105901 aactgaaaaa ttaggaaata aattacaatt agttggtgac gacttatttg ttactaacac
   105961 agagagatta gaaaaaggaa ttgaaaatgg agtagctaac tctatattag ttaaagttaa
   106021 tcaaataggt acaataactg aaactttaga tgctatagaa atggctaaga gagcaggata
   106081 tactgctgtt atatctcaca gatcaggaga aactgaagat tctactatag cagatttagc
   106141 tgttgcagta aatgctggtc aaataaaaac tggtgctcca tcaagaactg atagagttgc
   106201 taagtacaac caattattaa gaatagaaga aatggttgga gagcaagcta gatattgtgg
   106261 attaaaatct ttctataact taaaaaaata gttattaaaa tggttactaa aaaagattaa
   106321 tgaagagaga atataagata tttaagctca tcttataaga tataaaagag ataagtgtta
   106381 attgattttt caattcactt atcctttttt atattttatt acttaatttt attcatagat
   106441 tcagaaaaaa tatgaataaa tgtttctatc tcatttttat ctaattgcat aggaggtttt
   106501 tattaaaaaa taaaagtgaa gacatatttt gatttaatca taattgtcat taaagtatta
   106561 ttgctaaatg tggattattt attttaaatt atgttgaaat taaaagttat atcaatattt
   106621 taaaatgatt gttttatttt ggtggctatt tataatatat acaatgagag tagattattt
   106681 taagtgttaa tttatgcatt aatttaaata gttttctctt ctaagtttta ttcattttta
   106741 tattgagaat atagtaatat attatagtaa caatatattt ttttgtatgt tatttatagc
   106801 ataatagtct tgaaatggct atattattgt gatacactaa agagtaatga aatttaagta
   106861 ataaacagat aggaggggca agaatgagca acattttaat gggtgtgcaa gtagtactag
   106921 ggattttact agtaattagc ataatgcctc aagattctaa gaatgcttta ccttcagaat
   106981 ttggtggaga aggaagccaa gcttacttta aaccaaaagg aaaacaagca tttcttgcta
   107041 gagttacaaa gataacagca gtattatttt ttataaatgc attggcatta cttatagtta
   107101 agaagtagtg atattgttga ataactggcc attatttaat tagtgcattt gctagacatt
   107161 taaaaattaa atttagtttt taataaaagt acatcaacat aaaaagtacg taaaataaaa
   107221 gctggactaa tgattttata tgattagtcc agtttttatt ttatagattg actatttgtt
   107281 ggcgtttatt atttgtattt atatattgtt tgtatttata tatttttttc aaactaaaaa
   107341 atatatagca acactacttt caccatgttt aatgagataa tatacacaaa gttatattat
   107401 atagtaaaaa tagtataata atatgttttt acgcaattaa atcgatttta tatatgtttc
   107461 tcataatacc aatttgtgtt atcaaatatc attaaataag attattctgc tttaaaataa
   107521 atattattaa aaatactgta attatagaaa atccagaagt aaatactaca atttgtccag
   107581 ctaattcact gtcagaatcc atctgttgtg ccattgtaaa tgaagaaact gcagttggag
   107641 cagataacat tatcataagt gaagctaatt ctacatttct aaatccaaga aaaatgctaa
   107701 ttggtaaaaa tatagcaggt acaagtataa gttttccaca tacgcccaat ataatggggt
   107761 ttatatgccc ctttatagca gaaaaactaa aagagccacc tagaattata agtgataaag
   107821 gagtagctat tttagaaata tcaccaatag ttttgtgtaa aaatgtaggt atattaatat
   107881 ttaaaattag cattgtcaat cctataaaag aggcgattat gagtggattt gttaagacgc
   107941 ttttaatcat atgttttata tttactttgc cacctctaaa aatttcaaga attacaacag
   108001 ataatacatt aaacataggt acaataactg caattaataa agatgtgact ccaatactct
   108061 tatcgccaaa tagtgaaatt gtcacaggaa taccaaatat aacgaaattg ctacgaaata
   108121 caccttgtat taatgcaccc cttgtcttat tatctttttc aattttagga ataataaaga
   108181 ctaagattaa gaagattgaa aaaataatta taacagctac agccataagc ctaaaattaa
   108241 gagaaccatc taaatctgta ttgtatatat taaaaaataa taataatggc aagaaagact
   108301 tgaagcagac attattcatt ttatttaaag tatgagtatc aaatagacct aattttttta
   108361 gaacatatcc aagtgacatt gtgagaaaca aaggaagaac aacatttatt gataggatta
   108421 aattttccaa ggtttactct ccgtgattct atgatttgat aattcaatta aatttccatt
   108481 agtttttttc aaataaatag atttcatatt accaaagaca cctgtacatt ctacaattcc
   108541 tcgcttaatt tgaatctcat tttgttctaa gtattttttt ggctcatcaa tatttgtgtt
   108601 tattttaaaa cataagttat ctctacttgc ttgtaaattt ttaacataag gtaaaaattt
   108661 ataacctttt atgttaagat ttatcttaat atttctagca ttaagtttat aatttttgct
   108721 catttcttta gatgaaaaac caaatttttt ataaaaattg atataatttt ctatattatt
   108781 attagtaatg accacatgtt c
//
LOCUS       DAEPID010000003        98724 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.003, whole genome shotgun sequence.
ACCESSION   DAEPID010000003 DAEPID010000000
VERSION     DAEPID010000003.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 98724)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 98724)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..98724
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.003"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            98..214
                     /gene="rrf"
                     /locus_tag="KR257_000194"
     rRNA            98..214
                     /gene="rrf"
                     /locus_tag="KR257_000194"
                     /product="5S ribosomal RNA"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00001"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: cmsearch."
                     /db_xref="RFAM:RF00001"
     gene            334..525
                     /locus_tag="KR257_000195"
     CDS             334..525
                     /locus_tag="KR257_000195"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003427633.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF378 domain-containing protein"
                     /protein_id="HBH0028924.1"
                     /translation="MKKVALILAIIGALNWGAIGILGTDLIGSIFGGTYEMVSRIIYF
                     IVGLAGLYLIPSLMSDDRE"
     gene            680..2089
                     /locus_tag="KR257_000196"
     CDS             680..2089
                     /locus_tag="KR257_000196"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003427634.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aminotransferase class I/II-fold pyridoxal
                     phosphate-dependent enzyme"
                     /protein_id="HBH0028925.1"
                     /translation="MFIINELNKIVNEEVISFHMPGHKKGQVYKKLGYKDILKNLYKM
                     DTTEILGTDNLHFPEGIIKNSQKKASRVFKSDYTCYLVNGSSCGIQSAIMSVCSPKSK
                     IITNRDCHQSVINGCILGDIDIEYVPCEISEETNILKGISISNVIDIIDKNLDAKAVL
                     LTYPTYYGMTYDLEYICNYAHSKKMVVIVDEAHGAHLGLSERLPKTALEQGADIVVQS
                     THKTLPAFTQSSMIHIQGDRVDIDKILNMLRITESSSPSYLLLSSLELAVDIYENKGK
                     ELMEELLNNIITFKNKVDSNINIYDTNDKTKIFISSKNMGLTGYELENILRNKYNIQV
                     ELSNYYGVLLICTIGNTAEDFSSLETALNNVVKEDFKFEKLENKKYPVVIPKKILTPR
                     EAFYKTKKSVKIYDSIGKVCGECIVPYPPGISVISPGEVISKEIIDYLMFCHSKGMIV
                     SGLKDVDLNFIQVIDLEDI"
     gene            2220..2909
                     /locus_tag="KR257_000197"
     CDS             2220..2909
                     /locus_tag="KR257_000197"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892113.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="thymidylate kinase"
                     /protein_id="HBH0028926.1"
                     /translation="MKGKLIIIESGSDASGKATQTEILYERLKKEGYMIKKVEYPNYE
                     SPSSALVKMYLKGDFGKNASDVDPYIASTFFTADRYASFKTDWEEFYNEGGIIIADRY
                     TTSNMVHQASKMDICDREEYLNWLADYEFNLFKIPQPDCVIFLDVPIEFSKKLMENRK
                     NKITGEEKKDIHESDIEYLEKSYNNALYIADKYDWKKINCVLDNKLRSIESIHNEIYK
                     IVLDSIKPMER"
     gene            2912..3847
                     /locus_tag="KR257_000198"
     CDS             2912..3847
                     /locus_tag="KR257_000198"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421505.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA polymerase III subunit delta'"
                     /protein_id="HBH0028927.1"
                     /translation="MYFENIIGQDFAKKYLTNSIKKNKLNNAYMFEGMDGIGKKKFAD
                     ELSKLLLDYENLENSPDYVLIKPDGNSIKIAQIRNLQSDIVIRPHKDYKIYIINNAEK
                     MTVEAQNALLKTLEEPPNYAIIILVTNNKESLLETIKSRCDIIKFSPIPIEDLKRYLI
                     NTGIEEERAQLLAIFSRGSIENALNLSQSSEFSMMREDIQQYIQIMLDKNIVEILNIP
                     NNMEKYRGKIIALLDMMINYFRDIILLKENVNKNMLINVDKLVFIQNMNGKISYSQLS
                     KIIDIIEDAKSKIKSNCNFNISIQVMSLNIYEVIK"
     gene            3844..4737
                     /locus_tag="KR257_000199"
     CDS             3844..4737
                     /locus_tag="KR257_000199"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003427637.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="stage 0 sporulation family protein"
                     /protein_id="HBH0028928.1"
                     /translation="MIKIVGIRFKSAGKIYYFDPVDFNIEQDMDVVVETARGLEYGKV
                     VVGPKDMDESELVSPLKPIIRIATEEDKKVYLENKEKAKETFELCQQKIKEHELTMFL
                     IDCEYTFDRNKLIFYFTAEGRIDFRELVKDLAAIFKTRIELRQIGVRDEAKSIGGLGP
                     CGRKLCCSSWLGDFQPVSIKMAKDQSLSLNPTKISGICGRLFCCLKYEHDVYSEAIEK
                     MPVVGALVQSDDGKGKVVEVNPLLEQIKVEFQDKTVKIYTREDIKILREPKKCDGCGG
                     KCKDNDGLDEATLRELKKLED"
     gene            4815..5561
                     /locus_tag="KR257_000200"
     CDS             4815..5561
                     /locus_tag="KR257_000200"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003427638.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA1(Val) (adenine(37)-N6)-methyltransferase"
                     /protein_id="HBH0028929.1"
                     /translation="MQLKDSERIDDLQLKGLKIIQDTNGFCFGIDAVLLANFTKIKKD
                     AKVVDLGTGTGIIPILIAGKSEAKKIIGVEIQEDVYEMATRSIKLNGLEERVEIINED
                     IKYIDKVLDINGYHVVTSNPPYMHIDGIKNPNDKKAISRHEVRCNLEDVIRAASRLVM
                     PRGKFFMIHRPTRLVDIITLGRKYKLEPKVIQFVHPRPQKAPNLVLVQFVKDGRPELK
                     ILDPLYVYGEDGNYTKELKAIYNNKDIGEL"
     gene            5562..6395
                     /gene="rsmI"
                     /locus_tag="KR257_000201"
     CDS             5562..6395
                     /gene="rsmI"
                     /locus_tag="KR257_000201"
                     /EC_number="2.1.1.198"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435873.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="16S rRNA
                     (cytidine(1402)-2'-O)-methyltransferase"
                     /protein_id="HBH0028930.1"
                     /translation="MSGKLYICPTPIGNLEDITYRTLRILKEVDLIAAEDTRHSIKLL
                     NHFEISKPLTSYHEHNKDSKGDYLINKLIDGENIALISDAGMPGISDPGEEIIKQAIQ
                     NNIEIEVLPGATAFVTALVGSGMDTHRFIFEGFLDRDKKVRKAQLEELKEESRTIIFY
                     ESPHRLKDTLKDMLKILGNRNISINRELTKKYQEIIRENIETTIKIFEEKEVRGEFVL
                     IVEGFHGEKSKKENYDGLTDREYVLKLIESGMNKKDAIKIVCKDRKLKKDVVYKQVLD
                     L"
     gene            6418..7122
                     /locus_tag="KR257_000202"
     CDS             6418..7122
                     /locus_tag="KR257_000202"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435869.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HDIG domain-containing protein"
                     /protein_id="HBH0028931.1"
                     /translation="MEIGKIIIESLKREDTHKIFIELDNKHELEKIIPKISCMKSVGE
                     CKYHVVNCFEHSINALKELEIVLNDKDFFPIHLRKHVSNYLKTYIEEGINKLHVLKLG
                     TFLHDIGKPDSMTLDETGRVHFTNHEKIGAQIIDNMGIKLELSTETYRLISKYVRYHM
                     ILLSLYKKNDLSRKELINVFNLVDEDTIGVIMLGYADIVSTVKLLGKSGEVSVLKTYM
                     EYILTNYLYKSNYTHV"
     gene            complement(7310..7738)
                     /locus_tag="KR257_000203"
     CDS             complement(7310..7738)
                     /locus_tag="KR257_000203"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007287587.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Lrp/AsnC family transcriptional regulator"
                     /protein_id="HBH0028932.1"
                     /translation="MDVTDYRIIEILQDDGRISMKDLGKIVGLTSPAVSERVKRLEES
                     GVIEGYKAIVNPDSLGRVIKAFIHISLPSNGYTEFIESAAKDPRIVECHHITGDDCLL
                     LKVIVKDMYELENVIDTIKKIGSTKTSVILSTPIQAKSIL"
     gene            complement(7775..9205)
                     /locus_tag="KR257_000204"
     CDS             complement(7775..9205)
                     /locus_tag="KR257_000204"
                     /EC_number="6.3.4.21"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421492.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nicotinate phosphoribosyltransferase"
                     /protein_id="HBH0028933.1"
                     /translation="MRNLTLLTDLYQLTMLNGYFEKNIHEDIVVFDMFFRKNACDGGY
                     TIVCGIDQVVEYIDNLHFSDEDLEYLKNLNLFSDKFLKFLKEFKFTGDIYAVEEGTIM
                     FPNEPLITVKAPLYQAQLIETALLTIVNFQSLIATKASRVCFAAQGDPVFEFGLRRAQ
                     GPDAGIYGARAAVVGGCAGTANVLAGKMFDIPIIGTQAHSWVQKFDNELEAFQAYADV
                     YPDKCLLLVDTYDVLNSGVPNAIKVFKNISEKGYKPMGIRLDSGDLAYLSKEAKKQLD
                     NAGFSDISITASNDLDEYTITSLKAEGATINSWGVGTKLITSFDSPSLGGVYKLAASC
                     EKGVLEPKIKISENPEKINNPGYKKVIRIYNEDNKAEADLIMLHDEVIDESKPLEIFH
                     PTYTWKTKVFTNYKVKELLKPLYIKGRCKYNKKAVLEIKNHVQYELSTIWEQYKRLSK
                     PHIYKVDLSRNLWYLKTQMIDSKKVL"
     gene            9337..9921
                     /locus_tag="KR257_000205"
     CDS             9337..9921
                     /locus_tag="KR257_000205"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421491.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="spore maturation protein A"
                     /protein_id="HBH0028934.1"
                     /translation="MIIIGKIWFYMVSIGIIGSLISKNMGELNKVILSETSKGIEFAI
                     SLAGIMALWMGIMNIAKESGLIEKIGQKLNPIMRRLFPSIPKGHKAMSYIVMNIALNM
                     LGAGNGATAFGLKAMSELQTLNNKKDTATNDMIMFMVINISSIQIIPFTIIKLRMDMG
                     AQNPSEIIFTTLFATIISTAVAIITCKFFQRRYR"
     gene            9937..10458
                     /locus_tag="KR257_000206"
     CDS             9937..10458
                     /locus_tag="KR257_000206"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003427661.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="spore maturation protein"
                     /protein_id="HBH0028935.1"
                     /translation="MEIFSNLLIPIIILYIVVYGKYKKIDVYDSFVKGAIDGLKAAWD
                     ILPYIIGIFLAIGIFKTGKGLDMLEWLFTPIANMMSIPKELIGLISVKPLSGSGALGM
                     YSELANRVGIGSLVEKMGATIVGSSETIFYTMAIYYGSLKIKNTRHTLSCAMISHVAG
                     VIAAVFICYVIFV"
     misc_binding    10524..10770
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00230"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="T-box leader; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /bound_moiety="tRNA"
                     /db_xref="RFAM:RF00230"
     gene            10854..12791
                     /gene="metG"
                     /locus_tag="KR257_000207"
     CDS             10854..12791
                     /gene="metG"
                     /locus_tag="KR257_000207"
                     /EC_number="6.1.1.10"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009894056.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="methionine--tRNA ligase"
                     /protein_id="HBH0028936.1"
                     /translation="MSKPSFYVTTPIYYPSGGLHIGHTYSTVAADTIARFKRFCGYDV
                     KFLTGTDEHGEKIQKKAIEQGMSEIEYLDGMIKDIKALWNTMDISYDDFIRTTEKRHT
                     DIIQKIFTKLYEQGDIYKGEYEGRYCTPCESFWTESQLLEGNKCPDCGRETYLVKEES
                     YFFRLSKYEDRLKELFKDDSFCFPAARKNEMVANFLDKGLEDLSVTRTTFDWGIKVPF
                     DEKHVIYVWVDALCNYITALGYMTDNDEEFKKYWPANVQIVGKEIVRFHTIIWPALLM
                     ALGLEVPKQVFGHGWILFADDKMSKSKGNVVYPEPIIERYGIDTLKYFLLREFAFGQD
                     GSYTHRNFVTRINYDLANDLGNLISRTVAMVEKYNNGIIPTAKVSTNFDADLKEQAVS
                     TRENFEAEMDKMQFHEALESVWKLVRRTNKYIDETMPWALAKDETKKDELDTVLYNLC
                     ESIRIIATLINPIMNETANKIYEHIGIKGQDDITTWESTKTFGLIGENVKVFKGEPLF
                     PRLDVEKEIEELTKMFSGKPPVEEKPLEHKEEITIDDLDKIELRVGKIISCEKHPKAN
                     KLLVSQVKIGPETRQIVSGIAEYYKPEDLVGKEVTVVCNLKPVKLRGVESQGMILAAG
                     DDGDPYVLPFTQGAKDGCEVR"
     gene            12821..13591
                     /locus_tag="KR257_000208"
     CDS             12821..13591
                     /locus_tag="KR257_000208"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898746.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TatD family hydrolase"
                     /protein_id="HBH0028937.1"
                     /translation="MLFDSHAHLNDESFDEDRDELIGSLKDKGVDLVVNPGADIETSI
                     TAIELAKKYDFIYSAVGVHPHDVSKLDDTAIETLRKLATENEKVVAIGEIGLDYYYDY
                     SPREEQKEWFKKQIELANELKLPIIIHDRDAHGDTFEIIKNTKNPEIGCVLHCYSGNV
                     ELAREYVKMGCYISIPGTVTFKNNKKTREVVREIPLERLFIETDSPYMSPEPHRGKRN
                     NPSQVSFVADKIAQEKGISYEEVCRVTKENAKKFFNIK"
     gene            13928..14359
                     /gene="phnG"
                     /locus_tag="KR257_000209"
     CDS             13928..14359
                     /gene="phnG"
                     /locus_tag="KR257_000209"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892105.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphonate C-P lyase system protein PhnG"
                     /protein_id="HBH0028938.1"
                     /translation="MYTVDSTKILINMNLEKLEKIYSMIKDTSSISIIKEPNLATVMV
                     RANESVKNTTFNLGEILVTECSVKVDESLGYGIVSENNNKKAIYLAVIDAVLHSNNSK
                     FDELKNYINKSVYEENLRYEQEIIDEFSLINKTKVQFNAMD"
     gene            14374..14949
                     /gene="phnH"
                     /locus_tag="KR257_000210"
     CDS             14374..14949
                     /gene="phnH"
                     /locus_tag="KR257_000210"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435864.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphonate C-P lyase system protein PhnH"
                     /protein_id="HBH0028939.1"
                     /translation="MVNYTQEIYRKMLDSASFPGKLNNIDNINIENNTKLLNGAIGIA
                     ITLLDQEVTFYIENYTQKDIKNIRALTMSNQIDYRKSDYIFLDINSEVDILQIKIGSF
                     EYPDESATIVHQVNDLSTYSQTKYIKLDLSGPGIKSKNSIYINGIREEFIERLSSINK
                     DYPIGIDLILVDKKGEIAFIPRSSKLSWEVL"
     gene            14952..16037
                     /locus_tag="KR257_000211"
     CDS             14952..16037
                     /locus_tag="KR257_000211"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003427680.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="carbon-phosphorus lyase complex subunit PhnI"
                     /protein_id="HBH0028940.1"
                     /translation="MAYVAVKGGEEAILQAKNILEFYRVKGDSLPIDVKQIEEQMSYA
                     VDKVMSEGSLYNKELSALAIKQAQGDILEASFYVRALRSTMPRITYSEPINTEEMRIK
                     RRISATFKDIPGGQYLGATRDYENRILNVELLEEDEKKNRHFRDSFINELETVDEIPE
                     FTKISNIFRKENLLQEEVCENKLEEVIDDITRNSLRFPVSRSAKLQALTRGESGVVSG
                     FAYAIVRGFGDEHPYISELRTGNVFIKVKHPIYEDEEIIIGDMLVTECEIVSKASQNK
                     TENSKTNSEDKNKMSLGYGLCMGNNENKAISMAILDKSLEPNSEKLAQDEEFVLLHID
                     GIDSLGFISHFKLPHYVDFKADVERIK"
     gene            16057..16926
                     /locus_tag="KR257_000212"
     CDS             16057..16926
                     /locus_tag="KR257_000212"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729334.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha-D-ribose 1-methylphosphonate 5-phosphate
                     C-P-lyase PhnJ"
                     /protein_id="HBH0028941.1"
                     /translation="MIYNYGFLDENTKKEIRRKILKAISIPGYQVPFGSRELPIAKGW
                     GTGGLQLTLSLIGKNDVVKVIDQGSDDSTNACNIRSFIASVSNVETTKDTLEATLIQT
                     RHRIPEEKLKSNQILIFQVPIPETLRIVEPSEVETRRMHSEEDYSRMWVYLYEDIVRF
                     NDISIAVEYPCKVNDRYLMNPSPIPRFDIKKLNMSDNLFLFGAGREKRIYAIPPYTKV
                     EPLEFEDYKFEEEKFEGKYCSLCNSTNTFLDEVYDSDTNEKYYSCSDTSYCEKVRLKN
                     NSIDVTIGGTWNE"
     gene            16919..17785
                     /locus_tag="KR257_000213"
     CDS             16919..17785
                     /locus_tag="KR257_000213"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009894050.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="HBH0028942.1"
                     /translation="MSKINDSKRLENIDKQVLIGRNINLIYGDGCEKCFESTGYESNN
                     ICKYCGSIVACNNVNLELYEGEVLGIVGESGSGKSTLLKILFFQEHANSGEVYISHYN
                     KDTNILELSDQKKRYIKNHFMGIVYQNPHLGLNLDFSSGGNIAEKLLMANLYNVEKIR
                     DRGKELLIKTNIPVERIDHKPKYFSGGMQQRVQIAKALSNNPPILLLDEVTTGLDVSV
                     QAEVLDLIREIQRELKISMIVVSHDFDVIKMLADRTIVMKNGSVIESGLTDQIMEDPQ
                     HPYTQQLINSLL"
     gene            17826..18539
                     /locus_tag="KR257_000214"
     CDS             17826..18539
                     /locus_tag="KR257_000214"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892101.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="HBH0028943.1"
                     /translation="MKETILEVNNFSKDFELHALNKTITACSNISFEVSKGEFLGIIG
                     KSGAGKSTILKSIYKTYIPTTGEIIFNSEIYGNVDLAKIGDREMINLRKKEIGYVSQF
                     LKTLPRITAIELVVHSLIESGFEKDCSYDMAKDILNQFEIKENLWDAYPNNFSGGEKL
                     RLNLAQAMVKKPRLLLLDEPTASLDNQSKIYVKEKMLELKSQGTTMIGIFHDIEFMET
                     VIDKTFTMTKGTISESGVA"
     gene            18540..19709
                     /locus_tag="KR257_000215"
     CDS             18540..19709
                     /locus_tag="KR257_000215"
                     /EC_number="3.6.1.63"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003427691.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha-D-ribose 1-methylphosphonate
                     5-triphosphate diphosphatase"
                     /protein_id="HBH0028944.1"
                     /translation="MIKLIHNANIVLEDMILENGHLIIEGDTIKKVSNDKIDYAFDFN
                     EIDEIIDAKNLYVIPGIIDIHSDAIEKEIEPRPSTLLPFNMAFYELDKKLPANGITTV
                     YHSISLGDGVGVRSIDNSLKMIKNIDSYKNIDSKSINHKVHLRYEVLYYEGLEKVLEL
                     LDENKIDYLSIMDHSPGQGQYTNPTFYKEYATKVWGVTENYVDTWLDDLVNLHDNLDW
                     NKIANIIGIAKTKNINVASHDDDTLEKMDFIKNIGINVSEFPITLEVAKHSKKLGVLT
                     CLGAPNIVRGKSHNNNLKAMDAILEDCCDIVCSDYLPSAMIKSMCIVAERINNLNKAV
                     SLFTSNPAKAVGIYDERGSIKENKKADLVLVDIDSEYPKVVNTIVNGKTVYKREV"
     gene            19713..20549
                     /locus_tag="KR257_000216"
     CDS             19713..20549
                     /locus_tag="KR257_000216"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003427695.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PHP domain-containing protein"
                     /protein_id="HBH0028945.1"
                     /translation="MLTELHCHTSISDNNFTTEEIIKKAAEKNINILAITNHDTLSGL
                     DEALVLGEHYGITIIPGIEISAYDYKNRKRVHILGYNIDLNSQEIKNLCNPMVCDRHK
                     ASVKMVNKIIDLGYKISLEDVKKYSSKTGIFKQHIMKALIDKGYTDNIYSNLYKELFH
                     RGNGKVYVSLKYVDYRDAIKAIKNSGGICVLAHPGQMDNFSAIEEMVKVGLDGIEVYH
                     PSHNKELEKESLSYAKKYNLVVTGGSDYHGFYSQHNYELGSKSLNKEDLFKFRLALGG
                     VL"
     gene            20550..21545
                     /locus_tag="KR257_000217"
     CDS             20550..21545
                     /locus_tag="KR257_000217"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861991.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="HBH0028946.1"
                     /translation="MSFLQVKNVGKSYGQVKVLKDISIDIEKGEFICLLGPSGCGKST
                     LLRIIAGLEDKHGGKIIINDKDMTNSPPESRNFGIVFQSYALFPNMNVYKNIAFGLEN
                     KNISKSNIDKKVKEVLEVVELSGYEKKYPSQLSGGQQQRVALARAIALEPDFLLLDEP
                     LSALDAKVRLKLREQIRSLHRKLGITTIMVTHDQEEALCLADKMVVMNRGEIIQVGTP
                     KEVYKNPETPFVADFIGTINFIDDGINKIAIRPEDIKVESNRDSKDKDIKVGEILDIE
                     FRGFNYRITVEYRSKQMKLDVVSKVAEQMKLCIGSKINFKIPKEGIVQYKSEGCA"
     gene            21563..23251
                     /locus_tag="KR257_000218"
     CDS             21563..23251
                     /locus_tag="KR257_000218"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009894042.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="putative 2-aminoethylphosphonate ABC transporter
                     permease subunit"
                     /protein_id="HBH0028947.1"
                     /translation="MITSKNKRRISDSTIQKYFLIFSVIVLIVFILFPLVSLLKNAFM
                     DTSGNFIGISNFSKYVENPSLIASFKNSIFVSTVSSLISLCLAFIYSYAITRTNIKFK
                     DFFKTMGMFPLFAPTMLYGISLIYLFGNKGIFTTMGLEVPLYGPLGIIISQILFTFPQ
                     AFLILSVALSMADYRLYEAADSLGASEFKKFCKITIPGIKYSLLSSFFVSFILAFTDF
                     GAAKVVGGNYNVLATDIYKQVVGQFNIPMGATVSMVMLIPVLIAFTLDKMASKKQGMT
                     ITAKSMPYKIKENKFRDRVFLIVCSFITLLIFILIFVSVIGSVIKLWPYNLSFTMEHY
                     TFKGILGSGIKTYLSSLKISTLTAIFGTIFVFFSAYMIEKVDKFPKLRQTAYLLSMIP
                     MALPGLVLGISYITFFNSASNPLNFLYGSTAILVIVNVVHFYSVCFITSNSSLKMLDK
                     EYELVAKSINIPFYKVFFNITVPMSITSILEIVVYYFVNSMVTVSALIFLYTPQTQTA
                     SISILKLDEIGYIGTSAAMAVLVLLTNIIVRLLYEFVTKKLKNNTQKWQQKDVA"
     gene            23263..24330
                     /locus_tag="KR257_000219"
     CDS             23263..24330
                     /locus_tag="KR257_000219"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898733.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="putative 2-aminoethylphosphonate ABC transporter
                     substrate-binding protein"
                     /protein_id="HBH0028948.1"
                     /translation="MKFKKLVSLGVLSTLLLSVITGCSTDSSGSDSKSDSKTKGDLTV
                     YTAIEEDSIEPYLATFKEKYPDIKLNIVRASTGDITARLLAEKDNPQADVVWGVAATS
                     LLVADDQGMLEPYAPKGSEEIESAFKDDKEVPSWVGIDAWMTGITVNTKELSDKNIPV
                     PSSYEDLIKPEYKGLISMPNPSSSGTGYLTVSALIQIMGEEKAWQYMDKLHENIGVYT
                     QSGSAPATSAASGEYPIGISFGYRGIKLKEEGYPVEVVFPKEGSGWDIEANALVKKDN
                     IKEASKVFLDWAISKDVMNEYSKNYAVTTISTGNPIPEGFPKKPLEQMIDNDLKSAAK
                     NREDILNKWISKYDGKTEKES"
     gene            24767..25762
                     /locus_tag="KR257_000220"
     CDS             24767..25762
                     /locus_tag="KR257_000220"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861991.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="HBH0028949.1"
                     /translation="MSFLQVKNVGKSYGQVKVLKDISIDIEKGEFICLLGPSGCGKST
                     LLRIIAGLEDKHDGKIIINDKDMTNSPPESRNFGIVFQSYALFPNMNVYKNIAFGLEN
                     KNISKSDIDKKVRDILEVVELSGYDKKYPSQLSGGQQQRVALARAIALEPDFLLLDEP
                     LSALDAKVRLKLREQIKSLHRKLGITTIMVTHDQEEALCLADKMVVMNNGEVIQIGTP
                     KEVYKSPKTPFVADFIGTINFIDDDVNMIAIRPEDIKVEFNRDFKEIDVKVGEILDIE
                     FRGFNYRITVEYCSKQIKLDVVSKVVEQMKLCVGSKINFKIPKERTIQYKSEGCA"
     gene            25780..27468
                     /locus_tag="KR257_000221"
     CDS             25780..27468
                     /locus_tag="KR257_000221"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009894042.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="putative 2-aminoethylphosphonate ABC transporter
                     permease subunit"
                     /protein_id="HBH0028950.1"
                     /translation="MITIKNKRRISDSKIQKCFLVFLVIALVVFILFPLISLLKNAFM
                     DTSGSFVGISNFSKYIENPTLIASFKNSIFVSTISSLISLCLAFIYSYAITRTNIRFK
                     NFFKTMGIFPLFAPAMLYGISLIYLFGNKGIFTIIGIEVPLYGPLGIIICQILFTFPQ
                     AFLILSVALSMADYRLYEAADSLGASEFKKFFKITIPGIKYSLVSSFFVSFILAFTDF
                     GAAKIVGGNYNVLATDIYKQVVGQFNIPMGATVSMVMLIPVLIAFTVDKIASKKQGMT
                     ITAKSMPYKIKENKFRDRVFLIACSFITLLIFILIFVSVIGSVIKLWPYDLSFTMEHY
                     TFKGISGNGIKTYLSSLKISILTAIFGTIFVFFSAYMIEKVDKFPRLRQISYFLSMIP
                     MALPGLALGISYITFFNSASNPLNFLYGSTTIMVIANIVHFYSVCFITSNSSLKMLDR
                     EYELVAKSINIPFYKVFFYVTLPMSITSILEVAVYYFVNSMVTVSALIFLYIPQTQTA
                     SISILKLEEIGYIGPSAAMAVLVFLTNIIVKLLYELTTKKLKTKTQKWQQKEVA"
     gene            27480..28547
                     /locus_tag="KR257_000222"
     CDS             27480..28547
                     /locus_tag="KR257_000222"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898733.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="putative 2-aminoethylphosphonate ABC transporter
                     substrate-binding protein"
                     /protein_id="HBH0028951.1"
                     /translation="MKFRKLVSLGILSTLLLSVITGCNNASSGSNLKSNNKIKGELTV
                     YTAIEEDSIDTYLTTFKEKYPDIKLNVLRLSVGDITARLLAEKDNPKADVLWGVAATS
                     LIILDDKEMLEPYAPKGFDKVNPVFKDDKKVPSWVGIDAWMTGITVNTKELSDKNIPV
                     PSSYEDLIKPEYKGLISMPNPASSGTGYLTVSELIQIMGEEKAWQYMDKLHKNIGVYT
                     QSGSAPAILAASGEYPIGISFGNRGIKLKGEGYPVEVVFPKEGSGWEIESNALVKKDN
                     IKEASKVFLDWAISKDAMNEYSKNFAVTTIDTGNPVPEGFPKNPLEQMIDNDLKSAAR
                     NREAILNKWIEKYDGKTEKES"
     gene            28739..29269
                     /gene="rnmV"
                     /locus_tag="KR257_000223"
     CDS             28739..29269
                     /gene="rnmV"
                     /locus_tag="KR257_000223"
                     /EC_number="3.1.26.8"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898732.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribonuclease M5"
                     /protein_id="HBH0028952.1"
                     /translation="MIKEIIVVEGRDDVTAVKRAIDAELITTGGFGFPKGVMERIKAA
                     NERRGVIIFTDPDFAGEKIRKKIASEVPGCKHAFLPREEAKKDGDIGIENATPQSIIA
                     ALNKVRTENTEKRDEFKQVDLIRNGLIGNEEASLRRDALGKILGIGYGNAKQFLNRLN
                     NYGVEREEFIDALKQI"
     gene            29440..30309
                     /gene="rsmA"
                     /locus_tag="KR257_000224"
     CDS             29440..30309
                     /gene="rsmA"
                     /locus_tag="KR257_000224"
                     /EC_number="2.1.1.182"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892086.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="16S rRNA
                     (adenine(1518)-N(6)/adenine(1519)-N(6))-
                     dimethyltransferase RsmA"
                     /protein_id="HBH0028953.1"
                     /translation="MDRLSSHNATKEVVQKYNFKFSKSLGQNFLIDSNIIDKILSGAR
                     ITRGDNIIEVGPGIGTLTREMGKIAEKVVAIEIDRNLIPILKDTLSDLDNTEVVNQDI
                     LKVDIQELVKDKLNGGPVKLVANLPYYITTPIVMKFLEEDIPVTDIVVMVQKEVADRM
                     NAIPGTKDYGALSIAVQYYCDTEIVAKAPRHMFIPQPNVDSTVIGLHVRDKRKYDVHN
                     EDIFFKTVKASFGQRRKTLLNSLGGLGFLNKDEIREVLKEANIDEKRRGETLSIEEFS
                     VLSNIINTKVSSK"
     gene            30375..31640
                     /locus_tag="KR257_000225"
     CDS             30375..31640
                     /locus_tag="KR257_000225"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729292.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0028954.1"
                     /translation="MGSKRKFKRDYIILEAKDINFRYKERVLPKAFAKVEVNDEKAII
                     ALYVENLKYVKDGYKAVAIKDDHGLIDLGNIILNEQGRGEFVLDLEDYDDEIKGIALL
                     YERNIPLIGFKGNKLENYEDILFQEVEEEEYEEYEELEEEDEEIEDNEESDRDEGSEE
                     EYIIEEYDEDEYEDYWEDDEDIDEGELKARTEVEDSGDEEIEEFNNYKEIENYNRVKV
                     QEEYIDIEYDEEEEEEEEVFEVNREEDRFVSSKPTKSKKVQKDQNNIEKIKRANGVSQ
                     GESGNKQTSTLLMPRQIKKGLKLFKEVKPFVTDYIDKTRWWKIEINPTTLCGYTMPYL
                     GYLNVLNYTMYSDAVLHSYKYRHYLFGVQYDEYNKRKHYIYAIPGNRNEQPDNGSTGF
                     LRYQACDNRTNSLGYWLCFIDSRQRNIVR"
     gene            31791..32906
                     /locus_tag="KR257_000226"
     CDS             31791..32906
                     /locus_tag="KR257_000226"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729293.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="M20/M25/M40 family metallo-hydrolase"
                     /protein_id="HBH0028955.1"
                     /translation="MINEQRILNEFLELVQIDSLSLKEGNVAKVLVKKLEEIGCSVVI
                     DNAGEKANGETGNIIATLKGNKEGKKILFSSHMDTVTPGIGVKPIVDEANGIIKSDGT
                     TILGSDDKAGIAAILEGLRYINENNIEHTDIQVVFSICEECGLVGAKNLDYGKIDSEY
                     AFILDSGGSPGEIIVKAPAQDVINVKILGKTAHAGLEPEAGISAIMVAARAIENMNLL
                     RIDEETTANIGIINGGTATNIVTGEVNIIAEARSLKENKLDVQTKHMVETFEKAAKDF
                     GAQIEIDVNRAYTPIDVSEDSEIIKLAKKAFSNLGIEGHTESTGGGSDTNILSKNGIE
                     AITLGIGMKNAHTLSEHIAIKDLYDSAKMVVEIIKEA"
     gene            33092..33988
                     /locus_tag="KR257_000227"
     CDS             33092..33988
                     /locus_tag="KR257_000227"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425940.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cation transporter"
                     /protein_id="HBH0028956.1"
                     /translation="METRYEEANKITIQSILWNVVLTIIKVIAGVIGNSSAMIADGLH
                     SASDIISSIGVLIGNYVSSRPGDREHNYGHEKAETLVSFVLSILLIFVSITIGIEAIK
                     SLFNLDALSVPSILPLVVSVISILIKEYQYRITIKVAKKINSPALKADAWHHRSDALS
                     SVAAFIGIGGSILGFKPLDPIASVVVAIFVAKVGISILISSVNELMDVSVDEEEIKEL
                     KFIVADTEGVKNLGDIKTRKHGAMAYVDLTICVDENLTVKQGHDIATKLEKHIIKHME
                     FVKGITVHVEPCTNCQGNKCNN"
     gene            34058..34855
                     /locus_tag="KR257_000228"
     CDS             34058..34855
                     /locus_tag="KR257_000228"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425938.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0028957.1"
                     /translation="MSKKRKLKKKAAILIGVVVFFIIYFISFRIGINMEKDKSEVPKK
                     VEKEEEDNRSLRTQIKEKKKVYISDKNIENIKIEEDMWDEIKLFFSDFKKVRNTTSSY
                     EAVYEGYSDDGVKFSTDLNFFRVYTVNKEEYYKVPVSSKDAFKKLLDESIYTSFDLLS
                     HYKDWKEVTITHGKEIKKVHRWKFDDLAHKMISKRVVGKVQPEKSKERSDYNFTINIK
                     GDNFDVKVDTMGKDYVKVTSKKNVSYYEVHTSLFDYLKNEIFEIGKK"
     gene            complement(34910..36262)
                     /locus_tag="KR257_000229"
     CDS             complement(34910..36262)
                     /locus_tag="KR257_000229"
                     /EC_number="6.3.2.8"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421457.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-N-acetylmuramate--L-alanine ligase"
                     /protein_id="HBH0028958.1"
                     /translation="MNIHFIGIGGISMSALAEICINKGYQVSGSDSNESYLLDKLRDQ
                     GATIYIGQKKDNISDDVNMVVYTAAVHPDNEELVAAKEKNKLVMNRATFLGQIMREYK
                     NSIAVSGTHGKTSTTSMLSTIFEYADLDPTILVGGNLSMIGGNVKIGNSNHFITEACE
                     YVDSFLNFNPKISIVLNVEEDHLDYFSGIDEIKASFNKFGKLLPPEGYFIINGDDENI
                     DDILYDVKATIIKYGRDSDNDAVIKDIHFDNSGHGIFRIEYEGRDLGEFELSVYGLHN
                     IYNASSAIMAALVSGIDLETIRKNIKIYKGVGRRFETKGYYKNALVVDDYAHHPTELK
                     ATLAAAKKLKKSTLWCIFQPHTYTRTKSLLGEFSEAFYAADKVIITDIYAAREKDPGD
                     IHSKDLVEKLYQNNVDAIYIKEFEDIVKYLRENVKDNDLVITAGAGPIYKVADLLVEK
                     "
     gene            36481..37359
                     /gene="purR"
                     /locus_tag="KR257_000230"
     CDS             36481..37359
                     /gene="purR"
                     /locus_tag="KR257_000230"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421455.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pur operon repressor"
                     /protein_id="HBH0028959.1"
                     /translation="MKFKRTERIGAIVKILSDNPNKIYTLSYFTNQFNAAKSTISEDL
                     LVVKNVFEKLHLGKVITISGAAGGVKYIPKTSIAENAEFLMELCERICDKSRILSGGF
                     LYLIDLIYDPTIAAKIGKIFASNIEYVDADYVVTMETKGIPMALMTAKAMNLPLVIIR
                     KDIKVSEGPTLSMTYVSGNSSKVESMSLPRKALKPDSKVIIIDDFMRGGGTIKGMVDL
                     MNEFGAEVIGTGVFISTTNPSEKMVKDYISLIQLDVNGDKIVVEPNLKTFKDEYRNED
                     LDEEEDSEFEFEIDED"
     gene            37515..37793
                     /gene="spoVG"
                     /locus_tag="KR257_000231"
     CDS             37515..37793
                     /gene="spoVG"
                     /locus_tag="KR257_000231"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421453.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="septation regulator SpoVG"
                     /protein_id="HBH0028960.1"
                     /translation="MKITDVRVRKLTEEGKMKCIVSITFDNLFVVHDIKVIEGHNGLF
                     IAMPSRKVGEGNFRDIAHPINAEMRQVLEDAVLQAYHEALVQWEVAAE"
     gene            38006..39385
                     /gene="glmU"
                     /locus_tag="KR257_000232"
     CDS             38006..39385
                     /gene="glmU"
                     /locus_tag="KR257_000232"
                     /EC_number="2.3.1.157"
                     /EC_number="2.7.7.23"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898727.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional UDP-N-acetylglucosamine
                     diphosphorylase/glucosamine-1-phosphate
                     N-acetyltransferase GlmU"
                     /protein_id="HBH0028961.1"
                     /translation="MNFKAIILAAGKGTRMKSKYPKVIHKVCGKEMVNHIIDVSKKSG
                     VKDTVVILGHEADVVKEKLAEEIIIAMQTEQLGTGHAVKMAKEYINDEDTIVVLCGDT
                     PLIKEETLKRLFEYHIENKYHATVLTTRVGNPTGYGRIIRDKKGDLLKIVEQKDANSE
                     EKMISEINSGIYCFNGKSLREALDLLNNNNSQGEYYLTDTAKIMRDKGLKVGAFAGST
                     IEELMGVNSRVELSKAEEIMRRRINESHMVNGVTIIDTNSTYIESDVMIGNDTIIYPG
                     VMLQGKTRIGSDCIIGMNSSITNSEIGDGTEIKNSTIIDSKVGENSTVGPYAYLRPKS
                     DLGNNVKIGDFVEVKNAIIEDGSKASHLSYIGDAHVGKNVNIGCGVVFVNYDGKNKFK
                     SIVKDNAFIGSNSNLVAPVVVEEKGYIATGSTITHDVPDGALAIARERQVIKEGWVEK
                     KNQKDDQSK"
     gene            39480..40430
                     /locus_tag="KR257_000233"
     CDS             39480..40430
                     /locus_tag="KR257_000233"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003361732.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribose-phosphate pyrophosphokinase"
                     /protein_id="HBH0028962.1"
                     /translation="MNTSGSEIKIIAGNSSKELAQKIADYIGVSVLDCEVGTFSDGEI
                     CVNMNETVRGCDVFVVQSTNSPVNDNLMELLILIDALKRASAGRITAVIPYYGYARQD
                     RKAKARDPITAKLVANLITAAGADRVLTMDLHAAQIQGYFDIPLDHLLGGTILANYFN
                     EKKIEDLVVVSPDLGSVTRSRKFANTLNGEVPIAIIDKRRPKANVCEVMNLIGDVKGK
                     NVILLDDMIDTAGTIVNAANALKEFGAKDVYACCTHGVLSGPAIERIANSEISELIVL
                     DTIQLPEEKRIDKIKIKTVAPLFGDAIRMIFSNESVSKLF"
     regulatory      41274..41359
                     /regulatory_class="riboswitch"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF01786"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="cyclic di-GMP riboswitch class II; Derived by
                     automated computational analysis using gene prediction
                     method: cmsearch."
                     /bound_moiety="cyclic di-GMP"
                     /db_xref="RFAM:RF01786"
     gene            41521..42042
                     /locus_tag="KR257_000234"
     CDS             41521..42042
                     /locus_tag="KR257_000234"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421446.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="prepilin-type N-terminal cleavage/methylation
                     domain-containing protein"
                     /protein_id="HBH0028963.1"
                     /translation="MKLKKNKKGFTLVELLVVIAIIGILAVVAVPALFSNINKAKVAS
                     VESDYSSVKSAALSYYSDTNKIPVTTTDKAGLTILETYMESLPDKADIGGKYKLIKVG
                     NKLVLQIGTDTEGVTLTEAQSAKLLSDIGKDKIYTGVTGDNFGDELTDTTKIDNKALY
                     IVLIDNTVMDSTK"
     gene            42194..43870
                     /locus_tag="KR257_000235"
     CDS             42194..43870
                     /locus_tag="KR257_000235"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898724.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type II/IV secretion system protein"
                     /protein_id="HBH0028964.1"
                     /translation="MAKKVRIGDKLVEKGYITEEQLKWALSEQKNSGKRLGEFLVQEG
                     LIDSNLLISVLKELLDIESIFLEGTEIDTLATKMVPENICKRYTVFPFKIDGNKICLA
                     MSDPQDREAVQDVRRMSGKDVEIFISSTEDINKAIGHAYAHSEINKAMTEYNKNRTGG
                     VRETVILEEDVNAAPIVRLVNNILENAVRMEASDIHIEQSENYMRVRFRIDGMLREYM
                     RMNSAPYKAVISRIKIMSDINISEKRIPQDGRIYLKVDNKPIDFRVSTMPTNRDEKIA
                     MRVLDKSNFMVSKEVLGIDEHGSKIYDELINTPYGLILVVGPTGSGKTTTLYSMLNQL
                     NTENRNLLTIEDPIEYELPGVNQSQINEKAGLTFASGLRAFMRQDPDIIMVGEIRDTE
                     TAEIAIRASLTGHLVLSTLHANTAVGAISRLLDMDVESFLITSSVLGVISQRLTRKIC
                     EHCKVSYEADIGEKKALGIDVNESVTIYRGKGCERCNNTGYKGRLGIFEMLEITPEIK
                     ELIDSSANQREILKMARKQGMVSLKEDIVKKVLNGKTTVEEMIRIILMTD"
     gene            43882..45090
                     /locus_tag="KR257_000236"
     CDS             43882..45090
                     /locus_tag="KR257_000236"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421443.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type II secretion system F family protein"
                     /protein_id="HBH0028965.1"
                     /translation="MKSFKYTVIKEDGKKQTDVIEANDFNEARNLLRKRNLRVIEIKE
                     SKNKNIRLSSRKRKKDLGADQISHFCRQFAIIVSSGINSISGLETLARRSTNITLREE
                     INRIVAEIKVGSTIADSMLSSKSKFPKLLGAMVATGEATGKLDEVLKSMASFYASEHR
                     VKQKLRNAATYPLIVLISSFIMIFIFTTFMVPKMINSITTVGATLPLITRIVMGFGMF
                     MKKFWIIVLLVIILFIYQFKKYLKTSVGRAHKDRVINKIPVLGKGINCMVATRFSRAL
                     YLFVSTGYPLVQGLDYIIDSVNNTMAEKILASAKDGITRGEGLAENLERYTYFDSVLV
                     QMIAIGEQTGELENISRQMAEFYEYESEIYLNRMASMIEPVLIIAVGIIVAILVVSIF
                     MPMLSIYDAM"
     gene            45105..46817
                     /locus_tag="KR257_000237"
     CDS             45105..46817
                     /locus_tag="KR257_000237"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437881.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PilN domain-containing protein"
                     /protein_id="HBH0028966.1"
                     /translation="MNKVYVSYYGDSISIVEGRYKHDKDKFYVKNFNVFSIEDIAQDF
                     SKEKYALLRYALENVKLKSRHVVFCLNTRDVILKPQKLPNMDKKDLDGFMKLEMDEMM
                     ALESDEYVFSYEVSSETPDNSDGDESSLNLIIGAIQKEEVNAIVEIMHEFDLVLDRID
                     TLSTAYLRMLKNLDYNDIMVTNISDNSTIINIYKKDTLFISDNIPIKITAKDMDMQLL
                     NVVEESKGLMNYYSSRNFGKVTDTILILGKRYSNKLIYETFSSAFSSYVSQGLTEIMD
                     ISDMITGDIDEDDINSIVELLGSMIEPKGKRDFENINFLPMDILRKQIKAKQMKNILK
                     IAPIVILILAIPYLCLIFSNNLANKELENVNGEIRNIESAYYQIGNIEKMIQSKSEEI
                     KVYDMLIGKKVKWENLLDDIDKNTPSKVELTSLSTTYQNLGTNNKADNSKSNKTTTDK
                     SSNNETKSSTKSDSNGDKTDNDLNEDKTTNVSEALTGNSETNSNNTDKDDKTPLYDKI
                     PNVINIEGNAKDSSYVGQFLYKLKGLYYFKDVKLHSIKSNAEDSNYTFSMTLYLKEGV
                     LTNE"
     gene            46810..47718
                     /gene="pilO"
                     /locus_tag="KR257_000238"
     CDS             46810..47718
                     /gene="pilO"
                     /locus_tag="KR257_000238"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425924.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type 4a pilus biogenesis protein PilO"
                     /protein_id="HBH0028967.1"
                     /translation="MNKDIFKKDIKDIFKMEVSLKGILIKVIILLAILSYGYFGLYPQ
                     YQKYIATKNSVKQATEKLNIYKEKTALMPKYEKQLEEVESELKEKSKNLLYDMQDGLF
                     LIGLDKKMKAYNIDLTSYDVGNVKEYEHFYGISTTISVRGDYRNVKKLMAYLEEQKNV
                     TQILDYTMTSYIEPEKEEEETTNNKDLIKNVNINKDTKIYWVEGENKWHLYKDCPLIK
                     EGEIIKNDKLLDRSTNYLCNTCVLRAATEKEAKKEVVAPKAEGVVDATFKFIMYTKEN
                     TTMILDTDNPSSWRPGKYNPFKSSAK"
     gene            47745..48311
                     /locus_tag="KR257_000239"
     CDS             47745..48311
                     /locus_tag="KR257_000239"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437877.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="prepilin-type N-terminal cleavage/methylation
                     domain-containing protein"
                     /protein_id="HBH0028968.1"
                     /translation="MSLYKNNEKGLTLLEVIIAVFILTIVLSISYKVFNGITSAVKKQ
                     QIITDAQVNINLINKYLNRDLENCKELTKTGSGNNYEYNIEMPDNVVKYEVSIETKKN
                     TEVYSVTRIQNNTIDTENEVREEIIYNQPLVQNNKEMKETPFKIEKQTGKSIYTVSIY
                     YNESVQESHKNSNLNNKTYTFDVMSRIG"
     gene            48348..48875
                     /locus_tag="KR257_000240"
     CDS             48348..48875
                     /locus_tag="KR257_000240"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425922.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="prepilin-type N-terminal cleavage/methylation
                     domain-containing protein"
                     /protein_id="HBH0028969.1"
                     /translation="MSKKNSERGFSLIEVLVAMAIMGIVLFAFFNIINTNNKANTKND
                     TDITSLNYVQSEIENLREKIKSGEFDFDSLDKLEDGTVVYEKLIDKSKKVVYDKVLSE
                     GDVSLYDTPYEKITTIKDEDGNLIDKGNITNKIKTIVEDKSGQIYKIAVTGKSMNDYS
                     SKKEVKIVTEIFKDK"
     gene            48896..50434
                     /locus_tag="KR257_000241"
     CDS             48896..50434
                     /locus_tag="KR257_000241"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425921.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0028970.1"
                     /translation="MRKWNKFKSERGAALVLVLVVVALLSIVGLIFSNQIANRIKSTK
                     TTNEGIQAKYLAETCVENSIDKAYEKLYDELEKMDNEFKSENQEKSISRSKLRNISDE
                     DFNNQDEENIEAERLGYMNNINFYLNKASSDLEKASMELKKLYDLDMLDYRDIEYVDA
                     NIISHRNSILEICKNYTSGDISKINEYILKEDIDSTTLIEAKLVNNDILLKKFLEENK
                     IENEHLNSAFSHTYKALDNISLAMQNMIEYRHTFHIDEPKVEVSNGIPDSQQYYELIQ
                     NPIINSMEYSWNSKWDTLENLLEILPNQTQGFNSLRVHLRNNVRKFEKLSDNISSGKK
                     NTAKNFLKYKELLYEISDQCNQLKSMSYEKIPVKYDNMALITTFDYIQNELLAEIKCR
                     LKELKPQEIDKTEGITIKIPFYKADYDMTKEGWPKLKENGSGAELSLMVTGDKNGIKE
                     VEVTDGKKNIIGLGVEENSNSKYKVDAIVNFNLNIDTNVVGNYDIKDKILINHDISSY
                     KKVN"
     gene            50534..51616
                     /locus_tag="KR257_000242"
     CDS             50534..51616
                     /locus_tag="KR257_000242"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437872.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type IV pilus twitching motility protein PilT"
                     /protein_id="HBH0028971.1"
                     /translation="MYIYDLLEQGIRLNASDIHITVGTNPVARVKGGFVKLSEQILTS
                     EVTMQMAKDIAGESMFKVIEEHGEADFSASLKTGERFRVNAYRQKGNYAIAIRTITAE
                     IPTFEKLGLPESIKSFTEKHKGLVLVTGPTGSGKSTTLASMINIINEKQQKHIITLED
                     PIEYVHHHKQSLVNQREVGTDTESFHSALRAILRQDPDVILIGEMRDPETVSIALTAA
                     ETGHLVFSTLHTVGAAKTIDRIVDMFQPSQQQQIKTQLSTVCEGVVSQQLLPTADGKG
                     RIAAIELMFATPAIKNLIREGKTYQIPNMIQTGVKVGMKTMDQDLMELYKNGKITKDM
                     ALSRCTDQEFMTRMIGGVNYNGYYNR"
     gene            51597..52379
                     /locus_tag="KR257_000243"
     CDS             51597..52379
                     /locus_tag="KR257_000243"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437871.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="prepilin peptidase"
                     /protein_id="HBH0028972.1"
                     /translation="MDIIIVNLYVFIVGIVFGSFFNVCIFRIPEGISISRPPSHCMSC
                     NTRLKPIDLIPVLSYLMSGRKCRYCYEKISSRYAIVELITGLLFLTVFMLYGISTSTI
                     YYLVLVSLLIIITFIDIDHFIIPDKILVFGAIFSMIFNLLFKEIPVKDSILGVFICGG
                     SVWIIVLLIEFVIKKECMGGGDIKLFAMLGFYMGVKNGLLTALLSVYVGAVYGICVII
                     ISRIKGKEYNSVIPYGPFISIGALITILSGKQLLELYFSMVI"
     gene            52481..53131
                     /locus_tag="KR257_000244"
     CDS             52481..53131
                     /locus_tag="KR257_000244"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425916.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="prepilin peptidase"
                     /protein_id="HBH0028973.1"
                     /translation="MEYIIIISLFFAHLINKSLCVFCDREKKNLYNTFFIYIITVVLS
                     VLIYLKFGISVECVQYMVLIPFLIIISIVDYYTIYVYDITIVSGIIVQGIIFLAFFNI
                     VQFDYINHIFGLLIGFIIPYIIAKLTKGLGYGDVGLYSLCCFALGNNYGFYVIVLSFI
                     LAFLFFIILYITKIFKDVDIRKQIPFTPFISLSTILIIFTEYNIFNFYYNLLYKFI"
     gene            53145..53705
                     /locus_tag="KR257_000245"
     CDS             53145..53705
                     /locus_tag="KR257_000245"
                     /EC_number="3.1.1.29"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421426.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aminoacyl-tRNA hydrolase"
                     /protein_id="HBH0028974.1"
                     /translation="MYVVVGLGNPGKKYEKTRHNVGFDVIDILAKEYNISVTKIKHKA
                     LIGEGRVGTEKVLLVKPQTYMNLSGETLIDIYKYYKVDLSNIVVVYDDIDLEVGKIRI
                     RKKGSGGTHNGMKSITKCLGSNDFPRVRVGVSKPEAGQDLADFVLSRFRKEESDNINE
                     ALEKAADAIDSIIRENIDMSMNKYNG"
     gene            53722..57108
                     /gene="mfd"
                     /locus_tag="KR257_000246"
     CDS             53722..57108
                     /gene="mfd"
                     /locus_tag="KR257_000246"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009894034.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcription-repair coupling factor"
                     /protein_id="HBH0028975.1"
                     /translation="MNDVFLYPLQNSKEYKDIINCIKNTKGSLLVNGLLPVQKPHISY
                     SIFNDLSRQMIFITSSDLEAKKVYEDLSFYMEDKVEYLGFQDIYFYHLDAKDRNEEAK
                     KLKVLLKLANKEKIILVTSIEAVLRKYIPKQVLLDSVSHYKVGDSLDLEKLTEKLVSL
                     GYERVSKIEGFGQFSIRGGIIDVFSLEYTNPIRMELFDDEIDSIRTFDVYSQKSIDKL
                     QQFSITPSREFIYPEKTTDALVKLKKETTKNTDEGTFQNIDYISSKTYFEGVENYIDY
                     IYPEENKSIFTYLADDAIVFINDITRLKERCENYINEFRENYKLNLERGLAIKNQGKL
                     LYHYTDLEYLVKDKSVVLNSLLPKSINNFSIKSIINFESREVPTFNGKVDLLVEELNR
                     LKYNGYKIILATNTLERANKLGKDLLDKGLETTISKDRDIEIKSSQVIIVPAHINSGF
                     QYKSIKFVVITDNEMIGVYKRASKTSNKKVKKGKKIESFLDLSVGDYVVHENSGVGRY
                     TGIEQITVNAIKKDYMKIVYQGGDNLYVPIDQMDKVQKYIGAEVEKVKLNKLGTNEWT
                     KAKAKVKKEIEDMTKDLIELYAKREKIQGYKFSKDTPWQAEFESLFPYQETEDQLKAI
                     EETKKDMESSKVMDRLVCGDVGYGKTEVAIRSIFKACMDQKQVAVLVPTTILAQQHYN
                     TFKERFENYPLRVEVLSRFKTPKQQKQIIEDAKKGLVDILIGTHRIISKDINLPNLGL
                     VVIDEEQRFGVKHKEALKKIKSTVDVLTLSATPIPRTLHMSLSGIRDMSVIEEPPQER
                     HPVITYVTESKESVIQDEIERELSRGGQVFFVYNRVEHIEEMASMIQKLVPDARVAVA
                     HGRMTSKSLENIILGFLNKDYDVLVCTTIIETGMDISNANTMIIYDADKMGLAQLYQL
                     RGRVGRSSRQGYAYLLYEKDKTLSEIAEKRLKAIREFTEFGSGFKIAMRDLEIRGAGN
                     ILGSQQHGHMAVIGYDLYVKMLNDAIKKVKGEPIVEEIDVEIDLSVNAYIPDNYIKDE
                     LIKIEMYKKIASIENKEDMLDIQEELEDRFSDIPKPVQTLLTIAYIKSLCKILKIEKI
                     RQLKDEILLVPITKYRTKQKIGYNIVTELEELLEKMCKVK"
     gene            57139..58134
                     /locus_tag="KR257_000247"
     CDS             57139..58134
                     /locus_tag="KR257_000247"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421422.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptidylprolyl isomerase"
                     /protein_id="HBH0028976.1"
                     /translation="MKKVITLVIAMILVVSVTACSSSKGETVATVEGTKISSDEFKKT
                     IALYKDSMEQTYGKDIWDKEVEKGVKYKDKFKDLILDQLITTEVIYSQAKKDNLLPKK
                     EDVEKSFKELKDAMGKDEKYKEQLKKLGIDDEFLRDQQEKDLAMQNYQSNFAKKTKIS
                     DEEMKKYYDTHKDEFKKDEVEASHILLKTVDDNNKPLSDKEKAEAKKKAEEALKEVKS
                     GEDFAKVAKKYSQDTSASDGGKLGFFSRGQMVAEFEDAAFSMKKGEVSDLVETQYGYH
                     IIKVTDRINEQTSFEDAKETIKDQLLKNKYQEQIEKLTKEAKVEKDEKVINKITI"
     gene            58258..58797
                     /gene="spoVT"
                     /locus_tag="KR257_000248"
     CDS             58258..58797
                     /gene="spoVT"
                     /locus_tag="KR257_000248"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892063.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="stage V sporulation protein T"
                     /protein_id="HBH0028977.1"
                     /translation="MKATGIVRRIDDLGRVVIPKEIRKTLRIREGDPLEIFTAKDGEV
                     ILKKYSPIGELNEFSQEYAETLAEVLGYGVLITDLDSIIAVSKLPKKDYKEKSISDEL
                     EAIISERTVKYSKDKNILPLFKEDQKEYTSQVIMPIISASGDCIGSIVVVSKDKDTIA
                     ESEEKSLKIAANFLGKQVQ"
     gene            58917..60530
                     /locus_tag="KR257_000249"
     CDS             58917..60530
                     /locus_tag="KR257_000249"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425909.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="polysaccharide biosynthesis protein"
                     /protein_id="HBH0028978.1"
                     /translation="MNNNKNKDSFLKGALILGLAGVIVKIMGGFFRIPLGNMIGSEGM
                     GYYQAAYPVYTLFLTLATAGFPTAVAKLVSEKVAIGNFKGANKIFKVSHTVLFITGII
                     SFCILFFGADYIVTNVMKNPGALYSMKAIAPALLFVPAMSAYRGYFQGRQDMTKIAVS
                     QVAEQFFRVVLGLTLAYLLMKSLGQTFGAAGAISGATIGSIASMLYLVFAYMLGRKER
                     RAEIDASQRFKDERVSYIFKKLLTVAIPITIGASVMPLVNMIDNVIVIRRLMEAGFTY
                     KVANSMFGQLTGMAMATINLPAVITTAMSMSLVPAISKAYALGNKSKARKDTKSAVKV
                     TLLIVLPCAFGMASLAIPIMGLLFPHEPSSVGTILFTLTPCVLFLGLIQTLTGIIQGM
                     GKPIVPVIALCVGMLCKIVISYTLTGIPDINVLGSAFGTVTAYFVAAMINLLYVKKHM
                     NVNFSKKEFIIKPFITVMTMFIMVKLSYGALVGFLGNSISTIIAICVGGIVYVVVILG
                     IGGIKKEEILTMPKGDKLYKLLKKVKLIR"
     gene            60637..62085
                     /gene="mazG"
                     /locus_tag="KR257_000250"
     CDS             60637..62085
                     /gene="mazG"
                     /locus_tag="KR257_000250"
                     /EC_number="3.6.1.9"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009894031.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nucleoside triphosphate pyrophosphohydrolase"
                     /protein_id="HBH0028979.1"
                     /translation="MGKISIVGLGPGDYSLISQGVLESLINSPKVFFRTEKHPIIDKL
                     KETIQYTSLDYFYEKEENFDNVYLKISEFIIEESAKGDLVYAVPGHPRVAEKTVSIIE
                     RLANEKHIAVEILPSMSFVDAMFNYLAIDPSEGFKLVDAFEIENSYIDLDTSMIITQV
                     YDKFIASNVKLKLMEHYDYNQEVCIVNGAGVKDLESKKFIKLCELDRNENFFDYLTSL
                     YIPKSSKKMYNTVHDLEIIVNTLRSPSGCEWDKKQTHQSLKNSVIEEAYELCNAIDNN
                     DIDEMVEELGDVLLQVIFHCQIGNEEGYFDLKEVVNGICKKLIHRHPHIFSGAKLDMS
                     KFEKTWEELKKEEKGESTITDGLRRIPKHLPALMKASKVQHKAALVGFDWDNVEDVFK
                     KIEEEYQELLDEHRVGNIKYIKEELGDLLFSIVNLARFLDIDSGEALNCTTEKFINRF
                     DFIEKSAMNLNKKLEDMTLEEMDEFWNQAKKQ"
     gene            62174..62452
                     /locus_tag="KR257_000251"
     CDS             62174..62452
                     /locus_tag="KR257_000251"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003153447.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HU family DNA-binding protein"
                     /protein_id="HBH0028980.1"
                     /translation="MNKAELVSKMAEKSGLTKKEAEAALNAFMSSVQDALVNNEKVQL
                     VGFGTFETRERAARQGRNPRDPEQVIDIPASKAPVFKAGKGLKDIING"
     gene            62524..62766
                     /locus_tag="KR257_000252"
     CDS             62524..62766
                     /locus_tag="KR257_000252"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421412.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RNA-binding S4 domain-containing protein"
                     /protein_id="HBH0028981.1"
                     /translation="MRLDKFLKVSRIIKRRTVAKDACDKGIVTINGKVAKSSSEVNIG
                     DTLEIQFGEKKMKFKINEVKEHVLKNDAKEMYKILE"
     gene            62828..63082
                     /locus_tag="KR257_000253"
     CDS             62828..63082
                     /locus_tag="KR257_000253"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421411.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sporulation protein YabP"
                     /protein_id="HBH0028982.1"
                     /translation="MEQNITLKDRSKLVISGVEHIYSFNDKRVELKTSVGEMVIEGEN
                     LDMSKLSIDENIISIDGTINSMVYAKPKKPQESFLKKVFR"
     gene            63083..63616
                     /locus_tag="KR257_000254"
     CDS             63083..63616
                     /locus_tag="KR257_000254"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421409.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0028983.1"
                     /translation="MIPFTQDVSIFYATIYGGILIGVLFDFYRGLRGNFKFINYFAII
                     FDVLFWFLATVIIFVTINLTEFFDLRYYHFVALFIGFILYYNTISKIVLSIINKIIRF
                     VRNSFKKVTHYIVSFLNNLYYVIIYSLHLLFDIIFYIPNIFIATRKSIKRKSNKKLKN
                     KKKSKPKKKKNKTKKRV"
     gene            63622..63906
                     /locus_tag="KR257_000255"
     CDS             63622..63906
                     /locus_tag="KR257_000255"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437861.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="septum formation initiator family protein"
                     /protein_id="HBH0028984.1"
                     /translation="MNLRKKFSGQIIVISLFLGISIFSMMTGFVFEYTKAKEYKKEIA
                     SLNKQLKKTEIQINSLKKDEKSYEGDLEDIARKRLNMVKPNETVYVDINR"
     gene            64019..64939
                     /locus_tag="KR257_000256"
     CDS             64019..64939
                     /locus_tag="KR257_000256"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009894028.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Ppx/GppA family phosphatase"
                     /protein_id="HBH0028985.1"
                     /translation="MKVGAIDIGTNSMRLLIADYRDGNFINRKKFVNTTRIGYGVDSK
                     GYIKEDAIKRNIKALKEFSDKCNDEKCEKIYCMGTSALRDSKNGDYFVKLAKEETGID
                     VDIVTGIEESNLGFKGVLEGIQGDDTIIVIDIGGGSTEFIVGDSEGIKFNKSENVGAL
                     RMTERFLKHDIIEDEEFEAMSSFIYDEIDKTLNHIKDRGLKTLIGIGGTITSLSAMNQ
                     ELEIYSMEKIHNSKIHKKEIEEILQKLIKMTLSDKKNLKGLQEKRADIITAGVKILNI
                     IMEKLEIEEITVSEYDNLEGLICQKSKKMY"
     gene            65029..67401
                     /gene="spoIIE"
                     /locus_tag="KR257_000257"
     CDS             65029..67401
                     /gene="spoIIE"
                     /locus_tag="KR257_000257"
                     /EC_number="3.1.3.16"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425898.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="stage II sporulation protein E"
                     /protein_id="HBH0028986.1"
                     /translation="MQRSVAVVKNKTVKPNVIKLISGYIDFTTAAFAVMGFLLSRSII
                     VDSVAPLGIAFFICASKIDKYKIPVFISTLLGILLSSNDFGNVAKYAVCLTIFMAMNK
                     KLKLSDSIAKVAFIGAIILLPISMGQAFFSNRYVYGLLIAGVEAIIMFISIYVFSYGI
                     GLMANVNNRMSVRTEEAISISLLLTFSIMGIGDISLFGISIRTILSTVLILLTSIVGG
                     ATMGASSGVIIGVASILNNMTSAVYMGIYSFSGLISGAFNKINKYFCILGYILSWTII
                     YLYTSGITSNMMQLRDILLGCLIVLVLPERLFNKIEKLIKSNVASNEIVYDYIMRSKN
                     LTNSRLNSIYKTYDDLADTFDKIREKDKVLDQRDIANVIDMIHNDECKSCSMRRMCWE
                     SRFNHTYTMIYNILEKIEEKGELSLNDIPKNFRKECMKPESIVKISNHYYKMFVLDYD
                     WSVKFSESRKLIANQIRSISKSIKSLSQDLEGDIMLDIEKEKNIYEQLERYDITVDKV
                     SYLTKSNSEFEISIEKKTCHDGCMCEDKIVNIISDLVGENMSVRKIGCHCLGGKCKAT
                     FVKSQKYKAVTEVSAMSRDGHILCGDNYTYMEINDGKYMMAISDGMGKGKKAYEESSA
                     TIDILEKMIDAKIKDEIVIDTINNMLLLKSSEEMFSTLDLGILDLKRGCLETIKMGAC
                     STYIKREDGEVDLISSSSLPVGILSDVKIDRKNVKVKEGDYVIMVSDGIVDAGRNNNL
                     GDNWLIYFLKNIETTNPKEISNLILDRALELQALQIEDDMTVLVTKICTK"
     gene            67752..69644
                     /gene="pepF"
                     /locus_tag="KR257_000258"
     CDS             67752..69644
                     /gene="pepF"
                     /locus_tag="KR257_000258"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898717.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="oligoendopeptidase F"
                     /protein_id="HBH0028987.1"
                     /translation="MNRKLCKAIIPLFISIFCMLIISIKADQGYQKNNDRAITVMNNN
                     DTEDDAEKKQEIDYEKTCWNLQSLFKSDDQWKKELKSFDKDTKELKNYIGKVTKSPTH
                     LSFALNIKEKLDIRLNKLSAYVKLKQDTNKNSYKYLDMNDSMSKSYGNYMGICSDLEL
                     EILKLSNKDYKKIISNKNINRKYGAYLRDIRRNKVHYLDDKSEDILSKVSSISSLPSQ
                     VYELFRNMDRKTNLTPAQYASELESSDRENRKKAYQDELITYNDNINTIAGLITGQVK
                     KNIFYSQERGYESSLEMYLEADNVDEKVYNNLIRTVNSNMDSLHKYIDLRKKVLKLDK
                     VHSYDMFVPMVKAVDNNINYEKAQSIVYSALSPLGKEYNDVVYKAFNEKWIDVYSHEN
                     KVSGGYCLSVYENHPYILLNYNNSLGSVSTLSHELGHAVYEYLSSKNQNYFNSNPSIF
                     THEVASTTNEALLYEMLIKEAKGNDEKAYYITQYLDLIKDTLYTQTMYAEFEKTIHEL
                     VEKGKSVNALVLNDVWGQLLKKYYGQSYELDQLSKVGWARIPHFYNSFYVYKYATGCS
                     AGVSFAQDILKNGSDNYMSFLKKGSSDYPINLLKSSGINLTNTKPIENTIKKFDSLVA
                     ELEKLL"
     gene            69758..70723
                     /gene="galU"
                     /locus_tag="KR257_000259"
     CDS             69758..70723
                     /gene="galU"
                     /locus_tag="KR257_000259"
                     /EC_number="2.7.7.9"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892053.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="UTP--glucose-1-phosphate uridylyltransferase
                     GalU"
                     /protein_id="HBH0028988.1"
                     /translation="MQVKVKKAVIPAAGLGTRFLPATKAQPKEMLPIVDKPTLQYIIE
                     EAVASGIEEILIITGRNKKSIEDHFDKSVELELDLEKKGKKELLEVVQNISNMINIHY
                     IRQKEPKGLGDAIYCARHFIGDEPFAVMLGDDIVDNDVPCLKQLTDAYEEYRTTILGV
                     QKVNQEDTNKYGIIEAKNIEGRVYKVKDMVEKPESGKAPSNIAILGRYIITPEIFDIL
                     KDLPPGKGGEVQLTDALKILSKKEAMYAYNFEGKRYDVGDKLGFLEATVDFALKKEDL
                     KEDFIKYLKHVCSEFDKNNNVLYNNTDEKIDLIEVNEARELEIQK"
     gene            71223..72827
                     /gene="rho"
                     /locus_tag="KR257_000260"
     CDS             71223..72827
                     /gene="rho"
                     /locus_tag="KR257_000260"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425893.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcription termination factor Rho"
                     /protein_id="HBH0028989.1"
                     /translation="MRRIFLILDDKVLEGLGSKTLVELREIAKELKIKSITTYKKNEL
                     IEIINSKSKNEEKVNEETKEKNEDIKEDIKNRKENIERESIEKEVEYKSPTKSYNKKE
                     IDTQNISQNQEHRNQRNDYNKTTSVNDSNKSSNISNRMVRNNNKNYYMPKQVDESKIV
                     DEFNTSKEDEVVGVLEILPDGFGFLRGSNYLSTEGDVYVSPSQIRRFNMKTGDKIKGI
                     TRHPKSGEKFRALLYVQKINDENPDTAIQRNAFETLTPIFPEERLTLETNRNEIATRI
                     IDLISPIGKGQRGLIVAPPKAGKTVLLKSVANSIAKNHPNVELIVLLIDERPEEVTDM
                     KESIEGDVIYSTFDQVSSHHVKVAEMVLNRAQRLVEHGKDVVILLDSITRLARAYNLT
                     ISPTGRTLSGGIDPGALHGPKKFFGAARNIRQGGSLTILGTALVETGSRMDDVIFEEF
                     KGTGNMELHLDRKLAEKRIFPAIDIYKSGTRRDDLLLDDEEKTALWRLRREMSNNSVM
                     EITDKVIELIKRTKDNKEFVKSIKNL"
     gene            72980..73180
                     /gene="rpmE"
                     /locus_tag="KR257_000261"
     CDS             72980..73180
                     /gene="rpmE"
                     /locus_tag="KR257_000261"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018591942.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L31"
                     /protein_id="HBH0028990.1"
                     /translation="MQKEIQPKYNPVEVRCACGNTFVAGSTKDEIKVEICSECHPFYT
                     GKQKNIEKGGRIDKFKKRFKMD"
     gene            73325..74218
                     /locus_tag="KR257_000262"
     CDS             73325..74218
                     /locus_tag="KR257_000262"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425891.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1385 domain-containing protein"
                     /protein_id="HBH0028991.1"
                     /translation="MAKQAVGGQAVIEGVMMQSKDKRAVAVRKSDGEIALKEDRIKSW
                     VRDKNIDKIPFVRGSFVMIDTMIQGIKSLNFSSEFFMEEAEEDKFDLFIKKIFKDKAN
                     DIIIIFSLVIAMLLSAGLFIFIPTLVGGAFSKVMPNDFMLNLIEGIIRIAILFAYIVL
                     ISRSKDIERVFQYHGAEHKSIYCYENDLELTVENARKFKRLHPRCGTNFLFIVMAVSI
                     ILFAFFGWPNPILRIFMRIICVPIVAGLSYEVIRVLGKYDNGFTKIIAYPGMMLQYFT
                     TKEPDDEQLEVALEALKAVVD"
     gene            74236..75084
                     /gene="prmC"
                     /locus_tag="KR257_000263"
     CDS             74236..75084
                     /gene="prmC"
                     /locus_tag="KR257_000263"
                     /EC_number="2.1.1.297"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437849.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptide chain release factor N(5)-glutamine
                     methyltransferase"
                     /protein_id="HBH0028992.1"
                     /translation="MTIKDIIIKYSDKLKDISDTPRLDTELLLQKTLGVDRLYIHLNL
                     NKELTEEQKTKFMGFAEERLNGRPIAYIVENREFMGLDFFVKEGVLIPRPDTETLVEE
                     IIEICREKKDVSILDIGTGSGAITISLAKYIENSKIMSFDISETALEIAKKNAIINEV
                     GEKIKYINSDLFTAISDSNIKFDIIVSNPPYIKKQDIETLHKQVKDYEPYNALEGGED
                     GLDFYRRITEQGKKYLNKCGILAYEVGHNQAEDVINIMKSNGYKKIYTKKDIQGIDRV
                     VIGYNI"
     gene            75128..76192
                     /gene="prfA"
                     /locus_tag="KR257_000264"
     CDS             75128..76192
                     /gene="prfA"
                     /locus_tag="KR257_000264"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421389.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptide chain release factor 1"
                     /protein_id="HBH0028993.1"
                     /translation="MLKKLEVLEDTYKDLSEKIGDPDVINDQKVWQKYIKEHADLEPI
                     VMKYREYKSVLDSIKESKEILQEESDEELRELAKMELAEMEEKVAPLEEEIKILLLPK
                     DPNDDKNVIVEIRGGAGGDEAALFAGDLFRMYSRYAERRRWKIELLSASDTGVGGYKE
                     VSFMIKGKGAYSRLKYESGVHRVQRIPSTESGGRIHTSTSTVAVLPEVEDVEVEINPN
                     DLRIDVFRSSGNGGQSVNTTDSAVRVTHIPTGEVVSCQDGKSQLKNKEQALKILKARL
                     YDKALAEQHKDIAAERKSQVGTGDRSERIRTYNFPQGRISDHRINLTLYKLDAFLDGD
                     IDEMIDALITVDQTEKMTAI"
     gene            76321..77001
                     /locus_tag="KR257_000265"
     CDS             76321..77001
                     /locus_tag="KR257_000265"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425887.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ZIP family metal transporter"
                     /protein_id="HBH0028994.1"
                     /translation="MILKVTIIGLLAGVIGTGLGGVISAIFKREVDKYLSFFMGLSGG
                     IMLAVVVFDLMKESMDKMGIINTVIFTFVGALITMYIKTKLDVSGNMASGYLIFISIL
                     LHNLPEGLAIGSSFMSTESLGITLAIVIGLHNIPEGLAMALGLVCNKMKLSKVILFTV
                     IAGLPMGLGSFLGVYFGGVFTSLIGVFLATAGGTMMYVVLEEIFPHSKSVYCIIGFLL
                     GTMIVNYI"
     gene            77030..78070
                     /locus_tag="KR257_000266"
     CDS             77030..78070
                     /locus_tag="KR257_000266"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009906516.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="threonylcarbamoyl-AMP synthase"
                     /protein_id="HBH0028995.1"
                     /translation="MKTIISNIDINNIDYEEIKIQAKLLREGKTVIFPTETVYGLGAN
                     ALDENAVKKIYEAKGRPSDNPLIVHIYEKEEVYDLAKDISDKAKLVIEKLWPGPITII
                     LNKKDIIPYKTSGGLDTVAIRMPSNVIARAIIKEAGIPIAAPSANISGRPSPTKAKHV
                     YEEMNGRVDGIVLGGDSNFGLESTVLDLTEETPMILRPGSITKEVLEELLGEVKLDPS
                     LSKKEDNQKAKAPGMKYKHYSPNADVYIISGKRENVATKINDMIKSNRDKGLKTGVMC
                     ISRNREFYDGEVIDLGNSLEEVASNLFDALIEMDKKGVDVIYSEEFPKTGVGQAIMNR
                     LLKSAGYKVIKA"
     gene            78087..78536
                     /locus_tag="KR257_000267"
     CDS             78087..78536
                     /locus_tag="KR257_000267"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437844.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="low molecular weight protein arginine
                     phosphatase"
                     /protein_id="HBH0028996.1"
                     /translation="MNILIVCTGNTCRSPMAEAILRKAIKESGRSIEEYSISSAGIST
                     ANGMGASENSIEVLKEIGIDLSNHRSKVITKKLIDESDIILTMTKSHKEILVQAVPKC
                     KEKVYTFKGFANKNEEDISDPFGGNLDIYRSTMREIMYSVNEIVKKI"
     gene            78553..79005
                     /gene="rpiB"
                     /locus_tag="KR257_000268"
     CDS             78553..79005
                     /gene="rpiB"
                     /locus_tag="KR257_000268"
                     /EC_number="5.3.1.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421381.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribose 5-phosphate isomerase B"
                     /protein_id="HBH0028997.1"
                     /translation="MKIGLGCDHGGYNLKKEIISYLESKGIECVDYGTNNATDSVDYP
                     VYGEIVANSVINKEVDYGILCCGTGIGISLAANKVPGIRCAVVSDVFSAKMSKAHNDA
                     NMLSLGERVLGKGLALEIVEAWINTDFEGDRHARRVNMIKSIEEKHNK"
     gene            79041..79670
                     /gene="upp"
                     /locus_tag="KR257_000269"
     CDS             79041..79670
                     /gene="upp"
                     /locus_tag="KR257_000269"
                     /EC_number="2.4.2.9"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437840.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="uracil phosphoribosyltransferase"
                     /protein_id="HBH0028998.1"
                     /translation="MSKVVETNHPLIQHKLTLMRDKNTGSKDFRELLTEIAMLMGYEI
                     TKDIPLKDVEIETPIQKTSSKVVAGKKLAIIPILRAGLGMVDGLVSLMPAAKVGHVGL
                     YRDPETLKPVEYYCKLPQDIGERDIIVVDPMLATGGSAVAAIDLLKSKGAKSIKLANL
                     VAAPEGIAEVQKYHDDVDIYVASVDERLNEHGYIIPGLGDAGDRLFGTK"
     gene            79971..80786
                     /locus_tag="KR257_000270"
     CDS             79971..80786
                     /locus_tag="KR257_000270"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898711.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="EF2563 family selenium-dependent molybdenum
                     hydroxylase system protein"
                     /protein_id="HBH0028999.1"
                     /translation="MKNCIVVRGAGDLATAVIHKLHNSGFKVVALEIEEPLAIRRQIS
                     FCEAVYEKKVTVEGVECIFCNTEKEIEEVLSQHKVALIIDPKGEKLSKLNPIVLVDGI
                     LAKKNLGTTKDMAPLTIALGPGFCAGEDVDVVIETMRGHNLGRIITNGRAEKNTGVPG
                     AIKGFSKERVMHSQYDGIMENVCKIGDIVEKGDLLCYINNYEKKHEVRATISGVLRGL
                     LKDGAKVNKNLKILDIDPRKEEVKNAFTISDKARCIAGGVLEAILNNGIYPQN"
     gene            81012..81449
                     /locus_tag="KR257_000271"
     CDS             81012..81449
                     /locus_tag="KR257_000271"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421374.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dCMP deaminase"
                     /protein_id="HBH0029000.1"
                     /translation="MRPSWDEYFMEIAEVVKKRSTCIRRQVGAVIVRDKQILTTGYNG
                     SPRNLEHCENIGCKRQELNIPSGERHELCRALHAEQNAIIQAAHNGISVDGATLYVTT
                     RPCVLCAKMCINAGILKIVYEGDYPDDMSTELLKEAGIELIKF"
     gene            81634..81861
                     /locus_tag="KR257_000272"
     CDS             81634..81861
                     /locus_tag="KR257_000272"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425867.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AtpZ/AtpI family protein"
                     /protein_id="HBH0029001.1"
                     /translation="MSKRNTHTEIAKLFSLISQIGLMIVISILGCTFLGKFLDSKLNT
                     TPVLTIIFLLLGVGGAFSGVYKTLIVYTRRK"
     gene            81866..82252
                     /locus_tag="KR257_000273"
     CDS             81866..82252
                     /locus_tag="KR257_000273"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425864.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP synthase subunit I"
                     /protein_id="HBH0029002.1"
                     /translation="MDIKLLNQVRSVTKGIVIFDVVLIVLMLITSTLSKPVLLGLIFG
                     SIIAMLNFRLLAISLEKSVTFPAGKAQAYASAQYAVRLFIMAVVLIASATVPHLNIIG
                     TALGLLSTKFVILSKNFINKLKRKEA"
     gene            82255..82959
                     /gene="atpB"
                     /locus_tag="KR257_000274"
     CDS             82255..82959
                     /gene="atpB"
                     /locus_tag="KR257_000274"
                     /EC_number="7.1.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437836.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="F0F1 ATP synthase subunit A"
                     /protein_id="HBH0029003.1"
                     /translation="MNQAHYYLIGNFKISETILVSWGIMAFLAIASYFLTRNLKKVPT
                     SKVQIFLEFAVGGLAKMVTDVMGKNTVKRMPYMIPYIGSLFLFFACSNLSPLLGLRSP
                     TTDLDTTAAWAMITFFMIYFAGVKFKGLSYFKELAQPLAIMLPINIIGELARPISLSF
                     RPFGNILGGTIIMGLFYQLLGFISSLIPGLSIPIGEILIPVPLHLYFDLFAGLLQAYI
                     FIMLTMVFISSAGELD"
     gene            83028..83288
                     /gene="atpE"
                     /locus_tag="KR257_000275"
     CDS             83028..83288
                     /gene="atpE"
                     /locus_tag="KR257_000275"
                     /EC_number="7.1.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421370.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP synthase F0 subunit C"
                     /protein_id="HBH0029004.1"
                     /translation="METAIVAAASAIGAGIAVATGIGAGIGQGIAAAKAAEAVGNQPE
                     AKGDITSTLLLGVAIAESSAIYGLVISIILLFVNPFFKYLGM"
     gene            83411..83908
                     /gene="atpF"
                     /locus_tag="KR257_000276"
     CDS             83411..83908
                     /gene="atpF"
                     /locus_tag="KR257_000276"
                     /EC_number="7.1.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009906514.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="F0F1 ATP synthase subunit B"
                     /protein_id="HBH0029005.1"
                     /translation="MEKALVGITWEFVFQIVNTFIIFLLLRKLLFKPVLNIIESREND
                     IKSDLVEGEKAKNEGLALKKEYESKINFAKDEGQEIIKQATIRAEQKSDDIVNTAKKD
                     ALDIKEKANKDIEQERQKVINEIKNDISNIALLAASKVIEKDLDKSKHEELIENFIKE
                     VGEAK"
     gene            83905..84450
                     /locus_tag="KR257_000277"
     CDS             83905..84450
                     /locus_tag="KR257_000277"
                     /EC_number="7.1.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425856.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="F0F1 ATP synthase subunit delta"
                     /protein_id="HBH0029006.1"
                     /translation="MINVIANRYAEALFQLGEEENSTDVLFKELEKVVDMMTKVSKDF
                     YKVLKSPLVSKSEKKNLVEIIFSKEVSSNIKNFLKVLVDKDRISYLEDIELAYKELLN
                     KKNNVIDGVAISAIPMSETDIKELEVKLSNKYNKNVTIENVVDKTILGGVLVRIGNEQ
                     IDGTVKTRLDKMKEKLSEVIS"
     gene            84467..85969
                     /locus_tag="KR257_000278"
     CDS             84467..85969
                     /locus_tag="KR257_000278"
                     /EC_number="7.1.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003405060.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="F0F1 ATP synthase subunit alpha"
                     /protein_id="HBH0029007.1"
                     /translation="MNLKPEEISSIIKQQIKNYENKVELTDTGSVLTVGDGIASVYGL
                     EKAMSGELLEFPGEIYGMALNLEEEVVGAVILGDDSEIKEGDIVKRTGRIVEVPVGEA
                     LIGRVVNSLGQPIDGKGPIAYTKTRPVESEAPGIIDRRSVYEPLQTGIKSIDSMIPIG
                     RGQRELIIGDRQTGKTSIVIDTILNQKGKDVICIYVAIGQKRSTIAQLVSSLEKGGAL
                     DYTIVVSATASESAPLQYIAPYAGAAMGEEFMYNGKHVLIVYDDLSKQAVAYREMSLL
                     LRRPPGREAYPGDVFYLHSRLLERAAKLSDELGGGSMTALPIIETQAGDVSAYIPTNV
                     ISITDGQIYLQPELFYSGVRPAVDPGISVSRVGGSAQIKAMKKVAGTLKLAYSQYREL
                     AAFSQFGSDLDEDTKKRLAQGERIVEILKQGEHQPIKVENQVMIIYAVINNHLEDIPI
                     DNIARFESELYAFVDNNYPEISRKILGGEDFTHDLTDAINEFKEKFVVEV"
     gene            85997..86875
                     /gene="atpG"
                     /locus_tag="KR257_000279"
     CDS             85997..86875
                     /gene="atpG"
                     /locus_tag="KR257_000279"
                     /EC_number="7.1.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421366.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP synthase F1 subunit gamma"
                     /protein_id="HBH0029008.1"
                     /translation="MAGAGIKAIKTRMGTVESTKQITKAMELVASSKLRKAKEKAEDS
                     REYFNTLYNTVKDIAQTTRGIRNEFLKEREVKNKCYVVVAGDRGLAGGYNSNVLKESV
                     SHMKGKKETVITVGKKAHEFFSKRNYNIAKDINSVEACGYEDATEISQTIIDLYKKGE
                     VDEVYIAYTKFKSALSQEVEILKLLPLVFEKDTDEQGMAVKEEKQNRSKVQYIPSAEA
                     VLSYIVPQFISGTVYGGILESFASEQGARRTAMESATDNANEMLSNLELSYNRARQSA
                     VTQEITEIVGGVEALK"
     gene            86888..88282
                     /gene="atpD"
                     /locus_tag="KR257_000280"
     CDS             86888..88282
                     /gene="atpD"
                     /locus_tag="KR257_000280"
                     /EC_number="7.1.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425850.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="F0F1 ATP synthase subunit beta"
                     /protein_id="HBH0029009.1"
                     /translation="MANVGKVVQIVGAVLDVKFDSEQSLPNLLNALVIKLGDKEIVAE
                     VAQHIGDDTVRCIAMSATDGLVRGMEVVDTGGPISVPVGDETLGRIFNVLGKPVDGKP
                     APKSAPKLPIHRPAPAYDELETTAEILETGIKVVDLLAPYLKGGKIGLFGGAGVGKTV
                     LIQELINNIAKQHGGISVFSGVGERTREGNDLYGEMSESGVINKTALVFGQMNEPPGA
                     RMRVALTGLTMAEHFRDEQGQDVLLFVDNIFRFTQAGSEVSALLGRMPSAVGYQPTLA
                     TEMGALQERITSTKKGSITSVQAVYVPADDLTDPAPATTFSHLDAKTVLSRQISSLGI
                     YPAVDPLESTSRILDPSIVGKEHYEVARGVQSILQRYKELQDIIAILGMDELSDEDKL
                     IVARARKIQRFLSQSFTVAEQFTGNPGQYVPVKETVRGFKEILEGKHDDLPESAFLFV
                     GTIEDAVRKAKGSM"
     gene            88285..88545
                     /gene="atpC"
                     /locus_tag="KR257_000281"
     CDS             88285..88545
                     /gene="atpC"
                     /locus_tag="KR257_000281"
                     /EC_number="7.1.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421364.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP synthase F1 subunit epsilon"
                     /protein_id="HBH0029010.1"
                     /translation="MASEFSLKVVTPSNTFYDGDVEMIVVRTTKGDKGVLKGHIPFVS
                     GIPVGTLKIKKEGSFKEAKIAEGFINVTQDKTVILTESAEWI"
     gene            89007..89387
                     /locus_tag="KR257_000282"
     CDS             89007..89387
                     /locus_tag="KR257_000282"
                     /EC_number="2.7.8.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861979.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="holo-ACP synthase"
                     /protein_id="HBH0029011.1"
                     /translation="MNIFDIGVDIIEIDRIRKAVDKNNRFLEKIFTDREIEYFNSKNF
                     KAESIAGNFAAKEAISKSIGTGIRVFNFKDIEVLRDEMGKPIVKTYNNLAKMCIDYNV
                     LEIKVSISHSKDYAIANAITIIKD"
     gene            89402..89863
                     /locus_tag="KR257_000283"
     CDS             89402..89863
                     /locus_tag="KR257_000283"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421362.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CBS domain-containing protein"
                     /protein_id="HBH0029012.1"
                     /translation="MMDKTAKEIMTTDVIVAKQDDSIADVANMLIAEKIGGLPVVDSE
                     NRVVGIISETDILKKEKYIEAPLYINLLQGLIFLDDLKKVEKDIKQVAAYKVGELMSK
                     DIIKVHEDDKFDDVANVMIKKSINRVPVVDDDNKLKGIICRYDIIKALYNE"
     gene            89884..90474
                     /locus_tag="KR257_000284"
     CDS             89884..90474
                     /locus_tag="KR257_000284"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892025.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0029013.1"
                     /translation="MRKKWTIVCIMFLALVIIVIGCQKRQSTKEEVYKDFQKQISDMN
                     YYSCKAEVEVVGNKSPHNYVLIHTYKKTDNYKLEVISPKHLKGKSIEYQGDKILVKNP
                     KISDVVELPNTGKNNQYLFVGDFIKNYLQNEEMKVKLSKGHLVLETFIPGDNKYFNKQ
                     VLYVNADTKNPEKMEVLDKEGVPRFTVKYKDFEYRN"
     gene            90489..91646
                     /gene="alr"
                     /locus_tag="KR257_000285"
     CDS             90489..91646
                     /gene="alr"
                     /locus_tag="KR257_000285"
                     /EC_number="5.1.1.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903781.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alanine racemase"
                     /protein_id="HBH0029014.1"
                     /translation="MQKITVPTWAEINLDNLRFNLNNIKNLLEEDIKICGVIKADAYG
                     HGAVEVAKLLEKEKVDYLAVARTAEGIELRQNGITLPILNLGYTPDEAFEDSIKNKIT
                     MTVYSLETAQKINEIAKSLGEKACVHVKIDSGMTRIGFQPNEESVQEIIELNKLEYID
                     LEGMFTHFATADEVSKEYTYKQANNYKFMSDKLDEAGVKIAIKHVSNSAAIMDCPDLR
                     LNMVRAGIILYGHYPSDDVFKDRLELRPAMKLKSKIGHIKQVEPGVGISYGLKYTTTG
                     KETIATVPIGYADGFTRIQKNPKVLIKGEVFDVVGRICMDQIMVRIDKDIDIKVGDEV
                     ILFGEGEVTAERIAKDLGTINYEVLCMISRRVDRVYMENNELVQINSYLLK"
     gene            91679..91966
                     /locus_tag="KR257_000286"
     CDS             91679..91966
                     /locus_tag="KR257_000286"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421359.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribbon-helix-helix protein, CopG family"
                     /protein_id="HBH0029015.1"
                     /translation="MYDKSKEKIEVTLPDSLISEVDSIVQMENSNREDFAKAAFQFYI
                     TQKKKIHIKESMKTGYREMGQINLSLAELGMTVEEVSSDDKNEGKIAQGEY"
     gene            91935..92318
                     /locus_tag="KR257_000287"
     CDS             91935..92318
                     /locus_tag="KR257_000287"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421356.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type II toxin-antitoxin system PemK/MazF family
                     toxin"
                     /protein_id="HBH0029016.1"
                     /translation="MKGRLPKVSTNCEIKRGDLYYADLSPVVGSEQGGVRPVLIIQND
                     VGNKYSPTVIVSAITSQINKAKLPTHVEISSNEYGLNKDSVILLEQIRTIDKKRLREK
                     IGCLDENMMIKVDDGLQISLGLFTF"
     gene            92489..93316
                     /locus_tag="KR257_000288"
     CDS             92489..93316
                     /locus_tag="KR257_000288"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425838.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transketolase"
                     /protein_id="HBH0029017.1"
                     /translation="MRDHKGLNEIARIIRRDIVSMIHRAKSGHPGGSLSVVEILTALY
                     FDEMNVDSSNPKMEDRDRFVLSKGHAAPALYATLAEKGYFDKEELNGLRKIGRMLQGH
                     PDMKGTPGVEISTGSLGQGFSVACGMAMASKLDNAPWNVYTLLGDGEVQEGIVWEAAM
                     SAAHYKLDNLIAFLDNNGLQIDGDIESVMSLGSIVDKFKAFGWNVIEIDGHDFDQIFA
                     ALDIAKSTVKKPTMIVAKTIKGKGISFMENQAGWHGTAPSDEELEKALLELGGADNE"
     gene            93309..94250
                     /locus_tag="KR257_000289"
     CDS             93309..94250
                     /locus_tag="KR257_000289"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903779.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transketolase family protein"
                     /protein_id="HBH0029018.1"
                     /translation="MSKMATREAYGKALVKLGQINDNVVVLDADLSKSTKTHDFYKSF
                     PDRFFNMGIAEQNLIGAACGLSTAGKIPFASTFAMFATGRAFEIIRNSVCYPKLNVKI
                     CATHAGLTVGEDGASHESVEDIAIMRAIPNMTVLVPADGVETEKIIFEIAKYNGPVYV
                     RLGRSSVPVLFDEDYKFEIGKGTVLREGKDVSIIACGIMVNEALLAQEKLQEEGISAR
                     VINMSSIKPIDKDLILESAKETNAIVTVEEHSIIGGLGSAVSEVVGESCPTIVKKVGI
                     KDTFGESGTPNELLKKYELTCDDIIKTVKEAIIAKRM"
     gene            94673..95767
                     /locus_tag="KR257_000290"
     CDS             94673..95767
                     /locus_tag="KR257_000290"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421350.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0029019.1"
                     /translation="MSEKVNVKTVISFAGAYVATVIGSGFATGQEIMQFFSFYGFAGI
                     IGGIISMVLFSWMGASVMSKGKELQLKEPIKIYRVYCGKYLGIFFEWFGPLFLFGVFV
                     VMISGAGATLTEYYGLNPFVGRVGMAVVALLTVSLGLDKLSKILGGIGPIIIIFTLLV
                     GGISLAKNIGNIGEAAQVLSTVKIAKPVPNAYLSGVIYTTYNTIVVMAFLTGLGASAA
                     NKKEAICGGILGGVALMAAAIMMHLAILSDIGNLYSKAIPSLFLADKISPVIGVLFSI
                     ILILGIYTTAVPLLWSVTNRFVDDKHPKFKLITLIAAILGLIGGFLPFDKLVGILYPY
                     TGYMGVIILVCVLYRQITKTSGYQEGISDK"
     gene            95993..96409
                     /locus_tag="KR257_000291"
     CDS             95993..96409
                     /locus_tag="KR257_000291"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009894025.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0029020.1"
                     /translation="MNVKFNIKGIIYGVIALVFVIGGFIFIPSMFVEKSKPIDYTVLQ
                     RNSIPEKILDVMDKYTNEERALAAKIDNKIYIIVTRGNNKYGIEMDKIESVVEEGKDV
                     LRVKIKYKDKEDSFPYIVVETNMSELPDRIELNATK"
     gene            complement(96591..97160)
                     /locus_tag="KR257_000292"
     CDS             complement(96591..97160)
                     /locus_tag="KR257_000292"
                     /EC_number="6.3.3.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421346.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="5-formyltetrahydrofolate cyclo-ligase"
                     /protein_id="HBH0029021.1"
                     /translation="MKKEFRKKVIESRKNKNANFVLSNSNLITEKLLQMEDIRNATNI
                     MLYLNFNNEVQTDNLIKKLLSLKKIVSSPITIKENHTLIPTQITDLKEGLRIGAYGIR
                     EPNEKSPTIDIKALDVVIVPAVAYDIHCYRLGYGGGFYDRFLENLRKDAITIGIAFDF
                     QIFDSIPKETHDAQLDYIVTETRIITPNS"
     gene            97314..98471
                     /locus_tag="KR257_000293"
     CDS             97314..98471
                     /locus_tag="KR257_000293"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425822.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="S41 family peptidase"
                     /protein_id="HBH0029022.1"
                     /translation="MYLVISKKKAIFLGVILVIITAMVTSAFQLTLGNKVVISKELYE
                     DYKKYDKLLGLESIIKQDFYKKVSDTDLVNGAAKGLFLGTNDKYSGYYTKDEMENLIN
                     DSEGSYVGVGMYIGASKDGGLVVVPMKDSPAEKAGVKSGDKLVKVNGKSVSYKNSDEA
                     VRMMKGKKGKTVELTILREDKQLNFKVKTDQIIEKSIESKVIDNDLGYIEITQFISST
                     YTDFDKALKELKAKNIKGLVIDLRNNPGGMLDICKEVADELIGEGTIVYTKDNKGNTE
                     YLKSDKEKLGLPIVVLTNGESASAAEILTAAIVDNKEGISVGTTTFGKGLVQSVVRLK
                     DGTGYKLTTAQYFTPNGDYINEKGIKPTIEEKDENKQLDVATKWLREQIDK"
BASE COUNT        39525 a        10653 c        18136 g        30410 t
ORIGIN      
        1 atgtgtagtt tttagagtgc taactctaaa gaaactagta ttactaggtt ctataaactt
       61 attaaaaact taatagaaat attaagcata aagattatgt ggttacaata gcagagagga
      121 tacacctgtt cccattccga acacagaagt taagctctct agcgctgatg gtacttggtg
      181 ggaaactgcc tgggagagta ggacgtagcc acgtaatttt ttttattttt tgtcaaaaaa
      241 aacaaaaaat acgtatttct tttttcattt cgggaaaact aaacacagga attatggact
      301 ttataaaaat ttaattcttg aggagtgata taagtgaaaa aagttgcttt aattttagct
      361 ataataggtg cgcttaactg gggtgcaatt ggtattctag gtacagactt aataggtagt
      421 atctttggtg gaacatatga aatggtaagt agaataatat acttcattgt aggtttagct
      481 ggattatact taataccaag tttaatgtct gatgatagag aataatttat gcttttatgt
      541 taaatacctc attctaaatg tttagaatga ggtatttaat tttataaaaa tattaatttg
      601 tttctttttt aatggtaaaa tagataagaa ttgaagtttt aaaaagaagt attatgtaaa
      661 aaaggagtac tattaatata tgtttattat taatgaatta aataagattg taaatgaaga
      721 agtaatatct tttcatatgc ctggtcataa aaagggacag gtttataaaa agttaggata
      781 taaagatata ctaaaaaatt tgtataaaat ggatacaact gagatattag gaacagataa
      841 tttacacttt ccggaaggaa ttataaaaaa ttcacaaaaa aaagcatcaa gagtatttaa
      901 aagtgattat acttgctatt tagtaaatgg tagtagctgt ggaatacaat ctgcaataat
      961 gtcagtatgt agtcctaaaa gtaaaataat aacaaataga gactgtcatc agtctgttat
     1021 aaatggatgt attttaggag atatagatat agagtatgtg ccttgtgaga taagtgaaga
     1081 gacaaatatc ttaaaaggga tatctataag taatgtgatt gatataatag ataaaaactt
     1141 ggatgcaaaa gcagtactgc ttacttatcc tacatattat ggaatgacat atgatttaga
     1201 atacatatgt aattatgcac atagcaaaaa gatggtagtg atagtagatg aagcacatgg
     1261 tgcgcattta gggcttagtg agaggcttcc taaaacagct cttgagcaag gtgcagatat
     1321 agttgtacag agtacacata aaactcttcc agcatttaca caatcgtcaa tgatacatat
     1381 acagggagac cgagttgata tagataaaat attgaacatg ttaagaatta cagaatcttc
     1441 aagcccttca tatttattat tatcttctct ggaattagca gtagatatat atgaaaataa
     1501 aggaaaagaa ttaatggaag agcttttaaa taatattata actttcaaaa ataaagttga
     1561 ttcaaatatt aatatatacg acacaaatga taaaacaaaa atatttatat catctaaaaa
     1621 catgggttta acaggttatg aactagaaaa tattttgaga aataaatata acatacaagt
     1681 ggagttatct aattattatg gagttctttt aatatgtaca ataggaaata ctgctgagga
     1741 tttctctagt ttagaaacag cattaaacaa tgttgtaaag gaagacttta aatttgaaaa
     1801 gttagaaaat aaaaaatacc ctgttgttat tccaaagaaa atattaacac ctagagaagc
     1861 attttataaa actaaaaaaa gtgttaaaat atatgacagt ataggtaaag tttgtggtga
     1921 atgtatagtt ccatacccac ctggaataag tgtaatatct cctggtgaag taataagtaa
     1981 agaaataata gactatctaa tgttttgtca ttctaaaggc atgattgtga gtggattgaa
     2041 agatgtagat ttaaatttta tacaagtaat agatttagaa gacatttaaa aattatgata
     2101 taaaagtaga tagaagtaga tagtttaaaa ttgtgaagag aaataaatag actgcttata
     2161 tagagatatc taataaaagt actaaaaaag taaaaagtgt ttgtatggag gatatgaaaa
     2221 tgaaaggtaa gttaataatt atagagagtg gttcagatgc aagtggaaag gctactcaga
     2281 cagaaatatt atatgaaaga ttaaaaaaag aaggctatat gattaaaaag gtagaatatc
     2341 caaattatga atctccatca tctgccttgg tgaaaatgta cctaaaagga gactttggta
     2401 aaaatgcatc agatgtagac ccatatatag catcaacttt ttttacagct gataggtatg
     2461 catcatttaa aaccgattgg gaggagtttt acaatgaagg tggaataatt atcgcagata
     2521 gatatacaac ctctaatatg gtacatcagg cctctaaaat ggatatttgt gatagagaag
     2581 agtatttaaa ttggttagct gattatgaat ttaatttatt taagatacca caacctgatt
     2641 gtgttatatt tttagatgtg cctattgaat ttagtaaaaa gcttatggag aatagaaaaa
     2701 ataaaattac aggggaagaa aaaaaggata ttcatgaaag tgacatagag tatttagaga
     2761 aatcttacaa caatgcttta tatatagcag ataaatatga ttggaaaaaa ataaattgtg
     2821 ttttagataa caaattaaga agtattgaaa gtatacataa tgaaatttat aaaatagttc
     2881 ttgattcaat aaaacctatg gagagataaa tatgtatttt gaaaatatta tagggcaaga
     2941 ttttgcaaag aaatatttaa caaattctat aaagaaaaat aaacttaata atgcgtatat
     3001 gtttgaagga atggatggaa taggaaaaaa gaaatttgca gatgaattat caaaactatt
     3061 acttgattat gaaaatctcg aaaatagtcc agactatgta ctcataaaac cagatggaaa
     3121 tagtataaaa atagctcaaa tcagaaattt acaatcagat atagtaataa gacctcataa
     3181 agactataaa atatatataa tcaataatgc tgaaaaaatg actgtggaag ctcaaaatgc
     3241 acttttaaag acgctagagg aacctccaaa ctatgctata ataatcttag ttacaaacaa
     3301 caaggaatct ttattagaaa ctataaaatc tagatgtgat ataataaagt tctcacctat
     3361 accaattgaa gacttaaaac gttatttgat aaatacaggt atagaagaag aaagagctca
     3421 attattggct attttttcga gaggaagtat tgagaatgct ctaaatctat ctcagtcttc
     3481 tgagttttca atgatgagag aagatataca acagtatatt cagataatgt tagataaaaa
     3541 catagtggag attttaaata taccaaataa tatggaaaaa tatagaggta agattatagc
     3601 tttattagat atgatgataa actattttcg agatatcatc ctattaaaag aaaatgtaaa
     3661 caagaacatg ttaataaatg tagataagct agttttcatt caaaatatga atggaaaaat
     3721 tagttattct caattgtcca agattattga tataatagaa gatgcaaaga gtaaaataaa
     3781 aagcaattgc aatttcaata taagcataca agttatgtct ttaaatatat acgaggtgat
     3841 taaatgataa agatagtagg tataaggttt aaaagtgctg ggaaaatata ttattttgac
     3901 cctgttgatt ttaatataga gcaagatatg gatgtagttg tagaaactgc aagaggcttg
     3961 gagtatggga aagtagtcgt tggtccaaaa gatatggatg aaagcgaatt agtttctcct
     4021 ttgaagccaa ttataagaat agctacagaa gaagataaaa aagtatatct agaaaataag
     4081 gaaaaggcaa aagaaacttt tgagttgtgc caacaaaaaa taaaagaaca tgagttaaca
     4141 atgtttttaa tagattgtga gtatacattt gataggaata agttgatttt ttactttaca
     4201 gcagaaggaa gaatagattt tagagaattg gtaaaagact tagctgctat atttaaaact
     4261 agaatagaac ttagacaaat aggtgtcaga gatgaagcta aatctatagg aggtctaggg
     4321 ccttgtggta gaaaactttg ttgttcatct tggttaggtg attttcaacc agtttcaata
     4381 aaaatggcaa aagaccaaag tctatctcta aatccaacaa aaatatctgg aatatgtggg
     4441 agattattct gttgcttaaa atatgagcat gatgtatata gtgaagcaat agaaaaaatg
     4501 cctgttgtag gtgcattggt gcaatcagat gatggaaaag gaaaagttgt agaagtgaat
     4561 cctttattag aacaaattaa agtggaattt caagacaaga cagtaaagat atacacaaga
     4621 gaagatataa aaatacttag agagcctaaa aaatgtgatg gctgtggtgg taaatgtaag
     4681 gataatgatg gattagatga agccacacta agagagctaa agaaattaga agattaaatt
     4741 taaggtaggg cttttcctac cttttttaaa gcaattaatg cttaaagtta ttaatatttg
     4801 aggagaattt atatatgcaa ttaaaagatt cagaaagaat agatgattta caattaaaag
     4861 gccttaaaat tatacaagat actaatggtt tttgttttgg tatagatgca gttttattag
     4921 ccaattttac taaaataaaa aaagatgcca aagtagtaga tttgggtact ggaactggca
     4981 ttatacctat tttgatagct ggaaaaagtg aagctaaaaa aattattggc gtggaaatac
     5041 aagaagatgt atatgaaatg gcaactcgtt ctataaaatt aaatggatta gaagaaagag
     5101 ttgagattat aaatgaagat ataaaataca tagacaaagt cttagacata aatggttacc
     5161 atgtagtcac atcaaatcct ccatatatgc atattgatgg aataaaaaat ccaaatgata
     5221 aaaaagcaat atcaagacat gaagtaaggt gcaatttgga agatgtaatt agagctgcat
     5281 ccagattggt tatgcctaga ggaaaattct tcatgataca tagaccaaca agattggttg
     5341 atataataac tttagggaga aaatataaat tagaaccaaa ggttattcaa tttgtgcatc
     5401 caagacctca aaaagcaccg aacttagttt tggttcaatt tgtaaaagat ggaaggccag
     5461 agcttaaaat attggaccca ttgtatgttt atggagaaga tgggaattat acaaaagaat
     5521 taaaagcaat atataataat aaagatatag gagagttgta aatgagcggg aaattgtaca
     5581 tatgtccaac accaatagga aacctagaag atataacata tagaacttta agaatattaa
     5641 aagaagtaga cttgattgca gcagaagata caagacatag tataaaactt ttaaatcatt
     5701 ttgaaatctc aaaaccacta actagttatc atgaacataa taaggattca aagggagatt
     5761 atttgataaa taaactaatt gatggtgaaa atatagctct gataagtgat gcaggtatgc
     5821 ctggtatatc tgacccagga gaagagataa taaaacaagc tatacaaaat aacatagaga
     5881 tagaagtatt gccaggtgca acagcctttg taacggcttt agttggctct ggtatggaca
     5941 cacatagatt tatttttgag ggctttttag atagagataa aaaagttagg aaagcacaat
     6001 tggaagaatt aaaggaagaa agtagaacta taattttcta tgaatcacca catagattga
     6061 aggatacact aaaagatatg cttaaaattc ttggtaatag gaatatttct ataaatagag
     6121 aacttacaaa aaaatatcaa gaaataataa gagaaaatat agaaactacc ataaaaatat
     6181 ttgaggaaaa agaagtaaga ggagagtttg tattaatagt agagggtttt catggtgaga
     6241 agtcaaagaa agaaaattat gatgggctta cagataggga atatgtttta aaactaattg
     6301 aaagtggtat gaacaaaaaa gatgcaataa aaatagtttg taaagataga aagttaaaga
     6361 aagatgtggt ttataaacaa gttttagatt tataaaacct gaatctgagg tgattttatg
     6421 gaaataggga aaattataat agagagttta aagagggaag atacacataa aatatttata
     6481 gaattagata ataagcatga attagaaaaa ataattccta aaataagctg tatgaagtct
     6541 gtaggtgaat gtaaatatca tgtagtaaat tgttttgaac attctataaa tgcattaaaa
     6601 gaattagaaa tagtattaaa tgataaggat ttttttccaa tacatctaag aaaacatgtg
     6661 tcaaactatt taaaaacata tattgaagaa ggaataaata agttacatgt attaaagctg
     6721 ggaacatttt tacatgatat aggtaagcct gacagtatga ccttagatga aaccggaaga
     6781 gttcatttca caaatcatga aaaaataggt gctcaaataa ttgacaatat gggaataaag
     6841 ttagagttat caacagagac atatagactt ataagtaaat atgtaagata tcatatgata
     6901 cttttgtctc tatataagaa aaatgatttg agtaggaaag aattaattaa tgtatttaac
     6961 ttagtagatg aggacactat aggtgtaata atgcttgggt atgcagatat agtgtctaca
     7021 gtaaaattat tgggcaagag tggagaagtc agtgtgttaa agacatatat ggaatatatt
     7081 ttaacaaatt acttgtataa gagtaattat acacatgtat aaatttagtt aatataattg
     7141 agttttagat gattaattga agtttgaaat atacggattt caaaaacata aaagaagttg
     7201 tctttgttgt aaaattatga aagacaactt tttttatatc aaaaattgaa attttattaa
     7261 ggatacttaa tggtctatta attaataaac cattagtatt taatttatat tacaatattg
     7321 attttgcttg tattggcgtt gatagtataa cagaggtctt agtagaacca attttcttta
     7381 tagtatcaat cacattttct agctcgtaca tatcttttac aattactttt aaaagtaagc
     7441 aatcatcacc tgttatatgg tgacattcta caatcctagg gtcctttgca gctgactcaa
     7501 taaattctgt atatccattg cttggaagag aaatatgaat aaatgccttt ataactctgc
     7561 ctaatgaatc tgggttgaca atagctttat atccttctat aacaccagac tcttctaatc
     7621 ttttgactct ttctgaaact gcaggagaag ttaaaccaac tatttttcct aagtccttca
     7681 tagaaattct cccatcatcc tgtaaaattt ctatgattct gtaatctgta acatccataa
     7741 ataaacagtc ccccttaaat aaaaataatt aatgctataa aactttttta gaatctatca
     7801 tttgtgtttt taaataccaa agatttctag ataaatcaac cttataaatg tgtggttttg
     7861 aaagtctttt gtattgttcc cagatagtac ttaattcata ttgtacatga ttttttattt
     7921 caagaacagc ttttttatta tatttgcatc tgccttttat atacaatggt ttaagaagct
     7981 ctttaacttt gtaatttgta aataccttcg ttttccatgt ataagtagga tggaagattt
     8041 ctaaaggttt agactcatct ataacttcat catgtaacat aatcaaatct gcctctgcct
     8101 tattgtcttc gttatatatt cttataactt tcttgtaacc aggattattt attttttctg
     8161 gattctcaga aatctttatc ttaggttcaa gaactccttt ttcacaagat gcagctaatt
     8221 tataaactcc tccaagagaa ggtgaatcga aagatgtaat gagctttgta cctactcccc
     8281 atgaatttat agtagctcct tctgctttaa gtgatgttat ggtatattcg tctaggtcat
     8341 tagatgcagt tatgctgata tctgaaaagc cagcattatc taattgtttt ttagcttctt
     8401 tagataaata agctaaatct ccagagtcaa gtcttatacc cataggtttg tatccttttt
     8461 cagaaatatt tttgaatact tttattgcat taggaactcc actgtttaat acatcataag
     8521 tatctacaag tagtaggcat ttatctggat aaacatcagc atatgcttgg aatgcttcaa
     8581 gttcattatc aaatttttgt acccaactgt gagcttgtgt accaattata ggtatatcaa
     8641 acattttccc tgctagtacg tttgcagttc cagcacaacc accaactacg gcagccctag
     8701 ccccatatat ccctgcatct ggaccttgtg cacgacgtaa tccaaattca aatacagggt
     8761 ctccttgagc tgcaaagcaa actctagatg ctttagtagc aataagagac tgaaaattaa
     8821 ctattgttaa caatgctgtt tcaataagtt gagcttgata taaaggtgcc ttaacagtaa
     8881 ttaatggctc attagggaac atgatagttc cttcctcaac agcatatata tctcctgtga
     8941 atttaaattc ttttaaaaat tttaagaact tgtcagaaaa taaatttaag ttttttaagt
     9001 actctaaatc ttcatctgaa aaatgaagat tatctatgta ttcaacaacc tgatcaatac
     9061 cacaaactat agtataccct ccatcacaag cgttttttct aaaaaacata tcaaatacaa
     9121 caatgtcttc atgaatattc ttttcaaaat agccatttaa catagtaagc tgatataaat
     9181 cagtaagaag tgttagattt ctcattattt ctctccttaa ttattattaa atattaaaaa
     9241 ttgtaaaaac tcccacactt atactaaaac ataatatagt acaactttca agtataaagt
     9301 attacctaac tatcataaaa ttatttaaag aggaggatga ttataatagg aaaaatatgg
     9361 ttttatatgg tatcgatagg aataatagga agcttgattt ctaaaaatat gggtgaatta
     9421 aataaagtta tattaagtga aacatcaaaa ggtatagagt ttgcaataag tctagctggt
     9481 atcatggcac tctggatggg gataatgaat atcgcaaaag aatcaggttt aattgaaaag
     9541 ataggtcaaa aactaaatcc tataatgaga agattatttc cttctattcc aaaaggtcat
     9601 aaagcaatgt cttatatagt tatgaatatt gctttaaata tgttgggtgc tggaaatggt
     9661 gcaacagcat ttggtttaaa agcaatgagt gagcttcaaa ctttgaataa caagaaagat
     9721 acagccacta atgatatgat tatgtttatg gtaatcaata tatcatctat acaaataatt
     9781 ccatttacta taatcaaact aaggatggat atgggggctc aaaatccaag tgaaataatt
     9841 tttacgactt tatttgcaac cataatatct acagcagtag caataataac atgtaaattt
     9901 tttcaaagaa gatatagata aaggggatgt agatacatgg agatattttc aaacttactt
     9961 ataccaataa taattctgta catagtagtt tatggtaaat ataaaaaaat agatgtgtat
    10021 gatagttttg taaaaggagc aattgatggg ttaaaagcag catgggatat cctaccatat
    10081 ataataggta tatttttggc aataggaata ttcaaaactg gtaaaggtct tgatatgtta
    10141 gaatggctat ttacaccaat agcaaatatg atgagtatac caaaagaatt aataggtcta
    10201 ataagtgtaa aacctttatc tggaagtggt gctttaggga tgtacagtga acttgcaaat
    10261 agagttggaa taggaagttt agtagaaaaa atgggtgcta cgattgtagg ttcttctgag
    10321 actatttttt acacaatggc aatatactat ggaagtctga agataaaaaa tactagacat
    10381 acattatcat gtgctatgat tagccatgtt gcaggtgtca tagcagctgt ttttatttgc
    10441 tatgtaatat ttgtataatt tgttgacaat atgggaaaaa ttttataata tagtgattat
    10501 atagaaacaa atagtaatac aaattacaag ctatgaaaag aagagtaaat aaaggttttt
    10561 tctatcagag agctaggtta ggtgaaagct agtgtcaaaa gctttattga agatggtctt
    10621 ggagcttttt atctgagcaa gtgtgctagg gtaaaacggt tggacacgtt atagtctact
    10681 aaggtatcta taaaatgttt ctacatttca tgtgaaacat aactattata gatgaattag
    10741 ggtggtaccg tgaataatct cgcccctatg ttaactcata ggaggcgatt ttttattatt
    10801 taaatgaaag aatcatatga ttacgaacga taaaaaatta ggaggtaaat aacatgagca
    10861 aaccgagttt ttatgtaaca acaccaatat actatccaag tggaggatta cacataggac
    10921 atacttattc aacagtagct gcagatacaa tagctagatt caagcgtttc tgtggatatg
    10981 atgtaaagtt cttaacagga acagatgagc atggtgaaaa aattcaaaag aaagccatag
    11041 aacaaggaat gtcagagata gagtatcttg atggaatgat aaaagatata aaggccttat
    11101 ggaatactat ggatatatct tatgatgatt ttataagaac tacagaaaaa agacatacag
    11161 acataataca aaagatattt actaaactat atgagcaagg tgatatatat aaaggtgaat
    11221 atgaaggtag atactgtact ccttgtgaga gtttctggac agaatctcaa ttactagaag
    11281 gaaataaatg ccctgactgt ggaagagaaa catatttagt aaaagaagaa tcttatttct
    11341 ttagattatc taaatatgaa gacagattaa aagagttatt taaagatgat agtttctgtt
    11401 ttcctgctgc tagaaaaaat gaaatggtgg caaacttttt agacaaagga ttagaagatt
    11461 taagcgtaac tagaacgact tttgactggg gtataaaagt tccttttgat gaaaaacatg
    11521 taatttatgt gtgggtagat gctttatgta actatataac agcattaggt tatatgactg
    11581 ataatgatga agaatttaaa aaatattggc ctgccaatgt tcaaatagta ggtaaagaaa
    11641 tagtgagatt ccatacaata atatggccag cgcttttaat ggctttaggt ctagaagttc
    11701 caaaacaagt atttggacat ggatggatac tatttgctga tgataaaatg agtaaatcaa
    11761 aaggtaatgt ggtttatcca gaacctataa tagaaagata tggaatagac acacttaagt
    11821 acttcttatt aagagagttt gcatttgggc aagatggaag ttatactcat agaaattttg
    11881 taacgagaat aaattatgat ttagcaaatg atttaggaaa cttaataagt agaactgtag
    11941 ctatggttga aaaatacaat aatggtataa taccaacagc aaaagtttca actaattttg
    12001 atgctgactt aaaagaacaa gctgtttcaa ctagagaaaa ctttgaagct gaaatggata
    12061 aaatgcaatt ccatgaagca ttagagagtg tatggaaatt agttagaaga actaacaaat
    12121 atatagatga aactatgcct tgggcactag ctaaagatga aactaagaaa gatgaattag
    12181 acacagtttt atataattta tgtgaatcta taagaataat cgcaacacta ataaatccta
    12241 taatgaatga gactgctaat aaaatatatg aacatatagg aataaaaggt caagatgata
    12301 taactacatg ggaaagtaca aaaacatttg gtcttattgg agaaaatgta aaagtattta
    12361 aaggtgaacc tttattccca agattagatg tagaaaaaga gatagaagaa ttaactaaaa
    12421 tgttctctgg gaaacctcca gtagaagaaa aacctttaga gcataaagaa gaaattacta
    12481 ttgatgattt agacaaaata gagcttagag tagggaaaat aataagctgt gaaaaacatc
    12541 caaaagcgaa taaattatta gtatcacaag ttaagattgg accagaaaca agacaaatag
    12601 tatcaggaat agctgaatac tataagccag aggatttagt aggaaaagag gttacagtgg
    12661 tatgtaactt aaaaccagtt aaattaagag gtgtagaatc tcaaggtatg atattagcag
    12721 caggtgatga tggagaccca tatgttttac catttacaca aggggctaaa gatggatgtg
    12781 aggttcgtta gtaggtaatt aaatagtaag gagattaaag atgttatttg actcacatgc
    12841 acatttaaat gatgaaagtt ttgatgaaga tagagatgaa cttattggtt cattaaaaga
    12901 taaaggtgta gatttggttg taaatccagg agcagatata gagacgtcga taacagcaat
    12961 tgaacttgcg aaaaaatacg actttatata ttcagcagtt ggggtacatc cacatgatgt
    13021 atcaaaacta gatgatacag caatagaaac tctaagaaaa cttgcaactg agaatgaaaa
    13081 agttgtagct attggagaga ttggattaga ttattattat gattattctc caagagaaga
    13141 acaaaaagag tggtttaaga agcaaattga attagctaat gagctaaaac ttccaataat
    13201 aatacatgat agagatgcac atggagatac ttttgagata ataaagaata ctaaaaatcc
    13261 tgaaatagga tgtgtacttc attgttatag tgggaatgta gagttagcta gagaatatgt
    13321 taagatgggt tgttatatat caattccagg tacggttact tttaagaata ataaaaaaac
    13381 tagagaagta gtaagagaaa tacctctaga aagattattc atagagactg attcaccata
    13441 tatgtcacca gagccacata gaggaaagag aaacaatcct tctcaagtat cttttgttgc
    13501 tgataagata gcccaggaaa aagggatatc ttatgaagaa gtatgtagag ttacaaaaga
    13561 aaatgcaaag aaatttttta atataaaata gacaaattaa atcttataat gatatatata
    13621 ataagtcatt ataagtatag gatgagagtg cctcaaaatg agttttttag tttatgaggc
    13681 actctttttg tatgaaatca aatatatttt catcatttca acaatgaaaa agaagtttat
    13741 catattttga gatagtttgt ttttatttat ttaattcata ttttaaaata tattttctta
    13801 acattgttaa aaaagaattt acaagatatt cattagaatt aactcaactc taatattcac
    13861 ttaacttaag ttgtttatta tattattaaa gagaagtaaa cgaaaagtag attaaggagg
    13921 ttgaattttg tatacagttg atagtactaa gatattgata aatatgaact tagagaaact
    13981 agaaaagata tactcaatga taaaagatac atcaagtatt tctataatta aagaacctaa
    14041 cttggctaca gtaatggtaa gagctaatga aagtgtaaaa aacacaacat ttaatttagg
    14101 agagatatta gttactgaat gtagtgtaaa ggtagatgaa agcttgggtt acggaatagt
    14161 ttcagaaaac aataataaga aagccattta tttagcagtt atagatgcag ttttacatag
    14221 caataacagt aaatttgatg agttaaagaa ttacataaat aaaagtgtat atgaagagaa
    14281 cttaaggtat gaacaagaga ttattgatga atttagcttg attaataaaa cgaaagttca
    14341 attcaatgct atggattaaa taggaggaga atcatggtaa attatacaca agaaatatat
    14401 agaaagatgc tagatagtgc ttcatttcct gggaaattaa ataatataga taatataaat
    14461 atagaaaata atacaaaact attgaatgga gcaattggta tagcaatcac tttattagac
    14521 caagaagtta ccttctatat agaaaattat actcaaaaag atataaaaaa tataagagca
    14581 cttacaatgt caaatcaaat agattataga aaatcagatt atatattttt agatattaat
    14641 tcagaagtgg atatattaca gattaaaata ggttcttttg aatatcctga tgaaagtgca
    14701 actatagtac atcaagtaaa tgatttatca acgtactctc aaactaagta tataaagctt
    14761 gatttgagtg gtcctggtat aaaatctaaa aatagtatat atataaatgg aattagagaa
    14821 gaatttatag aaagattatc tagcataaat aaagattatc caataggaat agatttgatt
    14881 ttagtagata aaaaaggaga aattgcattt ataccaaggt catcaaaatt aagttgggag
    14941 gtattataga aatggcttat gtagcagtta aaggtggaga agaagccata ttacaggcta
    15001 aaaatatact tgagttttat agggtaaaag gagatagctt gcctatagat gtaaagcaga
    15061 ttgaggaaca aatgtcttat gctgtagaca aagtaatgtc tgaaggaagt ttatacaaca
    15121 aggaactatc agcattggct ataaaacaag ctcaaggtga tatattagaa gcctctttct
    15181 atgtaagagc tttaaggtca acaatgccta gaattacata ttcagaaccc ataaatacag
    15241 aagaaatgag aataaaaaga agaatatcag ctacttttaa agatatacca ggaggtcagt
    15301 atcttggggc aactagagac tatgaaaata gaatattgaa tgtagaatta ttagaagaag
    15361 atgaaaaaaa gaatagacat tttagagata gttttataaa tgaattagaa acagtagatg
    15421 aaatccctga atttacaaaa atatctaata tatttagaaa agaaaattta ttacaagaag
    15481 aagtttgtga aaacaaattg gaagaagtta ttgatgatat tacaagaaat agtttaagat
    15541 ttccagtttc taggtcagca aagttacagg cattaactag aggtgaaagt ggagtagtgt
    15601 caggttttgc ttatgctatt gtaagaggtt ttggtgatga acatccatat ataagtgaac
    15661 ttagaactgg taatgtattt ataaaagtaa aacatcccat ctatgaagat gaagaaataa
    15721 taatagggga tatgctggtt actgaatgtg aaatagtttc aaaagcatca caaaataaga
    15781 ctgaaaattc taaaactaat tcggaagata aaaataagat gtctttagga tatggtcttt
    15841 gtatggggaa taatgagaat aaggctatat ctatggccat actagacaaa tctttggagc
    15901 caaatagtga aaaactagca caagatgaag aatttgtatt gcttcatata gatggaatag
    15961 attcattagg atttatatct cactttaagc ttcctcacta tgtagatttt aaagcggatg
    16021 tagaaagaat aaaatagttt gaggaggtaa gtttaggtga tatataacta tggtttttta
    16081 gacgaaaaca caaaaaaaga aataagaaga aagatattaa aagcaatatc aatacctggt
    16141 tatcaagttc cctttggttc aagagagttg cctatagcta agggatgggg tactggaggt
    16201 ttacaattaa cactatcatt aattggtaaa aatgatgtag taaaagtaat tgaccaagga
    16261 agtgatgatt ctacaaatgc ttgtaatata aggagcttta ttgcaagtgt aagtaatgta
    16321 gaaaccacaa aagatacatt agaagctaca ttgattcaaa cgagacatag aataccagaa
    16381 gaaaaactta aatctaatca aatactaata tttcaagtac caataccaga aacccttaga
    16441 atagtagaac ctagtgaagt agaaacaaga agaatgcatt cagaagaaga ttatagtagg
    16501 atgtgggtat atctttatga agatatagtt agatttaatg atatatctat agcagttgaa
    16561 tatccatgta aagtaaatga tagatattta atgaatccat cacctatacc tagatttgat
    16621 ataaaaaaat taaatatgtc agacaattta ttcttgtttg gtgcaggtag agaaaaaaga
    16681 atttatgcta ttcctccata tacaaaggta gaacctttag agtttgagga ttataagttt
    16741 gaagaggaaa agtttgaagg aaaatactgt agtttatgta acagtacaaa tacattttta
    16801 gatgaagtat atgacagtga cactaatgaa aagtactata gttgctcaga tacaagttat
    16861 tgtgaaaaag ttagattaaa aaataacagt atagatgtga caataggagg tacttggaat
    16921 gagtaaaata aatgactcta aaagattaga aaatatagac aagcaagtat taataggaag
    16981 aaatatcaat cttatttatg gagatgggtg tgaaaagtgt tttgaaagca caggatatga
    17041 aagcaataat atatgtaagt attgtggttc tatagttgca tgtaataatg taaatttaga
    17101 actttatgaa ggagaagtcc ttggaattgt aggtgaatct ggttcaggaa aaagcacttt
    17161 attaaaaata ctgtttttcc aagaacatgc aaatagtgga gaagtatata tatcccatta
    17221 caataaagac acaaatatac tagagctttc agaccaaaaa aagagataca taaagaatca
    17281 ttttatgggt attgtgtatc aaaatcccca ccttggttta aatttagact ttagtagtgg
    17341 tggtaatata gcagaaaaat tattgatggc aaatttatat aatgttgaaa aaataagaga
    17401 tagaggcaaa gaacttttaa taaaaactaa tatacctgta gaaagaatag accataaacc
    17461 aaaatacttt agtgggggaa tgcaacaacg agttcaaata gcaaaagctc tttcaaataa
    17521 ccctccaata ttgctattag atgaggttac aacaggttta gatgtttctg tgcaagcgga
    17581 agtattggat ttaataagag aaatccaaag agaacttaag atttctatga tagttgtatc
    17641 ccatgacttt gatgttataa agatgcttgc tgataggaca attgtaatga aaaatggaag
    17701 tgtaattgag tctggtctta cagaccaaat aatggaggac ccacaacacc catatactca
    17761 gcaacttata aattcattgc tataaatatc gtttgtaaat aagcaaaatg ggggttttta
    17821 ataaaatgaa agaaactata cttgaagtaa ataattttag taaagacttt gagttacatg
    17881 cattgaacaa gactataacg gcatgtagta atataagttt tgaagtttca aaaggtgagt
    17941 ttttaggaat aataggtaaa tctggagcag gtaagtctac catattaaaa agtatctata
    18001 aaacatatat accaacaact ggagaaataa tttttaattc agaaatatat ggtaatgtag
    18061 acctggctaa aattggagac cgagaaatga taaatcttag aaagaaagaa ataggatatg
    18121 tatcacagtt tttaaagaca cttccacgaa taactgcaat tgaactggta gtacattctt
    18181 taattgagag tgggtttgaa aaagattgtt cgtatgatat ggcaaaagat atacttaacc
    18241 aatttgaaat aaaggaaaat ttatgggatg cgtatccaaa taatttttct ggtggagaaa
    18301 aattaagatt aaatttagct caagctatgg ttaaaaagcc tagacttttg ttacttgatg
    18361 aaccaactgc atcacttgat aatcaatcta aaatatatgt aaaagaaaaa atgttggagc
    18421 ttaaaagtca aggaactaca atgataggaa tttttcatga tatagagttt atggaaactg
    18481 ttatagataa gacctttact atgacaaaag ggactataag tgaaagtggg gtagcctaga
    18541 tgataaaact aattcataat gcaaatattg tattagaaga tatgatttta gaaaatggtc
    18601 atttaatcat agagggagat acaataaaaa aagtatcaaa tgataagatt gattacgcat
    18661 ttgactttaa tgagatagat gaaataatag atgcaaaaaa cttatatgta atacctggta
    18721 ttatagatat tcacagtgat gccattgaaa aggaaataga gccgagacca agtacattat
    18781 taccatttaa tatggcattt tatgaactag ataaaaaact acctgcaaat ggaataacta
    18841 cagtttatca ttctatatct ttaggggatg gagtaggagt tagaagtatt gataactctt
    18901 taaagatgat taaaaatatt gattcatata aaaatataga tagtaagagc ataaatcata
    18961 aagttcattt aagatatgaa gtgttgtatt atgaaggttt agaaaaggtt ttagaactat
    19021 tagatgaaaa taaaatagac tacttatcaa taatggacca ttctccagga caaggtcagt
    19081 atacaaatcc aacattttat aaagagtatg ctactaaagt gtggggagtt acagaaaatt
    19141 atgtagatac atggttagat gatttagtaa atctgcatga taatttagat tggaataaaa
    19201 tagctaatat tataggtata gccaaaacta aaaatataaa tgttgcatca catgatgatg
    19261 atacattaga aaaaatggat ttcataaaaa atataggcat aaatgtatct gaatttccta
    19321 taactcttga agttgcaaaa cattcaaaga aattgggtgt tctaacttgt ttaggtgcac
    19381 cgaatattgt aagaggtaaa tctcataata acaatttaaa agcaatggat gctatattgg
    19441 aagattgttg tgacattgtg tgttcggatt atcttccatc agctatgata aagtctatgt
    19501 gtatagttgc agaaagaata aataatttaa ataaagcagt cagtttattt acctcaaatc
    19561 ctgctaaagc agttggtata tatgatgaaa gaggtagtat aaaagaaaat aaaaaagcag
    19621 atttagtttt agtagatatt gatagtgaat atccaaaggt tgtaaatact attgtaaatg
    19681 gaaaaacagt ttataaaagg gaggtataaa gattgctaac agagttacat tgtcatacaa
    19741 gtatatcaga taataatttt actactgaag aaataataaa aaaagcagca gaaaagaata
    19801 taaatatctt agcaataaca aatcatgaca cattatctgg attggatgaa gctcttgtgc
    19861 ttggagagca ttatggaata acaataatac caggtataga aatttcagcc tatgattata
    19921 aaaatagaaa aagagttcat attcttggat ataacataga tttaaacagt caagaaataa
    19981 aaaatttgtg caatccaatg gtatgtgaca gacataaagc atctgttaag atggtaaata
    20041 aaattataga tttaggatac aaaatatctc tggaagatgt aaagaaatat tcatcaaaga
    20101 ctggaatatt taaacaacat ataatgaaag ctcttataga taaaggatat acagataata
    20161 tatattcaaa tctatataaa gaattgtttc atagaggaaa cggcaaggta tatgtatctt
    20221 taaaatatgt ggattacaga gatgcaataa aagctataaa aaattctggt ggaatttgtg
    20281 tgttagctca cccgggtcaa atggataatt ttagcgctat tgaagagatg gtaaaagtag
    20341 gattagatgg aatagaagta tatcatccat ctcacaacaa agaactagaa aaagagtcgc
    20401 tttcttatgc taagaagtat aatctagtgg tcacaggagg ttcagattac cacggatttt
    20461 attctcaaca taattatgaa cttggaagca agagcttaaa taaagaagat ttatttaagt
    20521 ttaggttagc tttaggaggg gtattataaa tgtctttttt acaagtaaaa aatgtaggta
    20581 aaagttatgg acaagttaag gtgttaaaag acatatctat tgatattgaa aaaggagagt
    20641 ttatttgttt actaggtcca agtggttgtg gaaagagtac actacttaga ataattgcag
    20701 ggcttgagga taaacatggt ggaaaaataa taataaatga taaggatatg actaattcac
    20761 cacctgaaag tagaaatttt ggtatagttt ttcaatcata tgcattattt ccaaatatga
    20821 atgtttacaa aaacatagcc tttggactag aaaataaaaa cataagtaaa tctaatattg
    20881 ataaaaaagt taaagaagtt ctagaagttg tagaattaag tggatatgag aaaaaatatc
    20941 catcacaatt atcaggtgga caacaacaaa gggttgcatt agctcgtgcg attgctttag
    21001 agccagactt tttacttctt gatgaacctt tatctgcatt agatgcaaaa gtaagactta
    21061 aacttaggga gcagattaga agtttacata gaaaactagg cattacaact ataatggtaa
    21121 cgcatgacca agaagaagct ctttgtttag ctgataagat ggttgttatg aatagaggag
    21181 aaataataca agttggaacg ccaaaggagg tatataaaaa tccagaaaca ccttttgtag
    21241 ctgattttat aggaacaata aattttatag atgatggtat taataagata gctattagac
    21301 cagaagatat aaaagtagag tctaatagag attctaaaga taaggatata aaagtgggag
    21361 aaattttaga tatcgaattt agaggattta actatagaat tacagttgag tatcgttcta
    21421 agcaaatgaa attagatgta gtttccaaag ttgcagaaca aatgaaactg tgcataggtt
    21481 ctaaaataaa ctttaagata cctaaagaag gaattgtaca atataaatca gagggatgtg
    21541 cttaatagct aggggtgaat aaatgataac atcaaaaaat aaaagaagaa taagtgatag
    21601 cacaatacaa aaatatttct tgattttttc ggtaattgta ctaatagtat ttatattatt
    21661 tccattagta tcattattaa aaaatgcatt tatggataca agtggaaatt ttataggaat
    21721 ttcaaacttt agtaaatatg ttgaaaatcc aagtcttata gcatcattta aaaattcaat
    21781 ttttgtatct acagtctcat ctttaatatc actatgttta gcatttatat attcatacgc
    21841 aataacaaga acaaacataa agtttaaaga tttttttaaa actatgggaa tgtttccact
    21901 ttttgcacca actatgttat atggtatttc acttatatac ctttttggaa ataagggaat
    21961 ctttacaacc atgggtctgg aagtaccact atatggtcca ttaggaataa ttatttctca
    22021 gattctattt acatttccac aagctttttt aatattatct gtagcacttt cgatggctga
    22081 ttatagactt tatgaagcag cagatagctt gggtgctagt gaatttaaga aattttgcaa
    22141 aataacaatt cctggtataa agtactcatt acttagttca ttctttgtat cctttatact
    22201 tgcatttaca gattttggag cagctaaggt agtcggagga aactacaatg tactggctac
    22261 tgacatatat aaacaagtag ttggacaatt taacatacca atgggagcta ctgtttctat
    22321 ggtaatgtta attcctgtac taatagcatt tacattagat aagatggcaa gtaagaaaca
    22381 aggtatgacc ataactgcaa agtctatgcc atataagatt aaggaaaata agtttagaga
    22441 tagagtattt ttaatagtat gtagttttat aacattgcta atttttattt taatattcgt
    22501 ttcagttata ggttcagtta taaagttatg gccatataat ttaagcttta caatggaaca
    22561 ctatacattt aaaggtattt tgggaagtgg aataaaaaca tacttaagca gtttgaaaat
    22621 atcaacttta acagcaatat ttggaactat atttgtattt tttagtgctt atatgataga
    22681 aaaggtggat aagtttccta aattaagaca aacagcttac cttttatcaa tgataccaat
    22741 ggccttacct ggcttagttt taggtatatc atatataact ttttttaact cagcaagtaa
    22801 tccattaaat tttttatatg gaagtacagc aatattagtt atagtaaatg tagttcattt
    22861 ttattcagtt tgttttataa cctcaaattc atctttaaaa atgttggata aagagtatga
    22921 attagttgca aaatccataa atattccatt ctataaagta ttttttaata taacagttcc
    22981 aatgtctata acatcaatac ttgaaatagt agtatattat tttgtaaatt caatggttac
    23041 tgtttcagca ttaatatttt tatatacacc tcaaactcag actgcatcaa tatcaatact
    23101 aaagttagat gagataggat atataggaac atcagctgct atggcagtat tagtgctttt
    23161 aacaaatata atagtaagac ttttgtacga atttgtaaca aagaaattaa aaaataacac
    23221 acaaaaatgg cagcaaaaag atgttgcata ggggaggtaa aaatgaaatt taagaagcta
    23281 gtttctttag gagtattatc aacactttta ttaagtgtaa taacaggatg tagtactgat
    23341 tcatcaggtt cagattcaaa gtctgatagt aagacaaaag gggatttaac agtttacaca
    23401 gcaattgaag aagatagtat agagccatat ttagctacat ttaaagagaa atatccagat
    23461 attaaattaa atattgttag ggcatcaaca ggagatataa cagcaagatt attagcagaa
    23521 aaggataatc ctcaagcaga tgttgtatgg ggagttgcag ccacaagctt attggttgca
    23581 gatgaccagg ggatgttaga accatatgct ccaaaaggtt ctgaagaaat agagtctgca
    23641 tttaaagatg ataaagaagt tccttcttgg gttgggatag atgcttggat gacaggtata
    23701 acagtaaaca ctaaagaatt aagtgataag aacatcccag ttcctagttc ttacgaagat
    23761 ttaataaagc cagaatataa aggtcttata tctatgccta atccatcttc ttctggtaca
    23821 gggtacttaa cagtatcagc ccttatacaa attatgggtg aagaaaaagc atggcagtat
    23881 atggataaat tgcatgagaa tattggtgta tacactcaat ctggttcagc tccagctaca
    23941 tcagcagctt caggagaata tcctattggt atatcttttg gatatagagg tataaagtta
    24001 aaagaggaag gctatccagt agaagtagta tttccaaaag aaggttctgg atgggatata
    24061 gaagcaaatg ctcttgtgaa aaaagataat ataaaagaag catcaaaagt atttttagat
    24121 tgggctataa gtaaagatgt aatgaacgaa tactctaaga actatgcagt tactactatt
    24181 tctacaggaa atccaatacc agaaggattc cctaaaaagc cattagagca aatgatagat
    24241 aatgatttaa aatcagcagc aaaaaataga gaagatatac taaataaatg gatatcaaaa
    24301 tatgatggta agacagaaaa agagagttaa gtaaaactat acaaatggag taaaaagaaa
    24361 gaattttttt aagtagattt tattataata atataagttg agaataatat aggtcaagaa
    24421 aagtgaatat tctataaaaa tgtatagagt aagtatacca ttcagtttga atggtatatt
    24481 ttttattttt agagattaat ttagaaatag atatactaca gtttaaaata gtatatttta
    24541 atttcattat taaagtatag atattatata taaagtaaat aaattattga gcgattatta
    24601 ataagatatg tataaatttt aatttgggaa cttgtgttat atatcatgaa aaaagagaaa
    24661 aaataaaagg taaattgttt cttgataact tgaaattgga agtgagaata tttaactaga
    24721 gaagaattat ttaagtttaa gtcagcttta ggaggaggaa ttataaatgt cttttttaca
    24781 agtaaaaaat gtaggtaaaa gttatggaca agttaaggtg ctaaaagaca tatctattga
    24841 tattgaaaaa ggggagttta tttgcttatt aggtccaagt ggttgtggta aaagtacatt
    24901 gcttagaata attgcaggac ttgaggataa acatgatgga aaaataataa taaatgataa
    24961 ggatatgact aactcaccac ctgaaagtag aaactttggt attgttttcc aatcatatgc
    25021 actatttcca aatatgaatg tatataaaaa tatagccttt ggattagaaa ataaaaatat
    25081 aagtaaatct gatatagata agaaggttag agatatttta gaagttgtag aattaagtgg
    25141 atatgataaa aaatatccat cacaattatc aggtggacaa caacaaaggg ttgcactagc
    25201 tcgtgcgatt gctttagagc cagacttttt gcttcttgat gaacctttat ctgcattaga
    25261 tgcaaaagta agacttaaac ttagggaaca gattaaaagt ttacatagaa aactaggcat
    25321 cacaactata atggtaacac atgaccaaga ggaagctctt tgtttagctg ataaaatggt
    25381 tgttatgaat aatggagagg taatacagat tggaactcct aaagaagtct ataaaagtcc
    25441 aaaaacacct tttgtagctg attttatagg aacaataaat tttatagatg atgatgtgaa
    25501 tatgatagca attagaccag aagatataaa ggtagaattt aatagagact ttaaagaaat
    25561 tgatgtaaaa gtaggagaga ttttggatat agaatttaga ggattcaact atagaattac
    25621 agttgaatat tgttctaagc aaataaagtt ggacgtagtt tcaaaggtag tggaacaaat
    25681 gaaactatgt gtaggttcta aaataaactt caagatacct aaagaaagaa ccatacaata
    25741 taaatcagag ggatgtgctt aatagctaga ggtggataaa tgataacaat aaaaaataaa
    25801 agaagaataa gtgatagtaa gatacaaaaa tgttttttag tttttttagt gattgcatta
    25861 gtagtattta tattatttcc attaatatca ctattaaaaa atgcatttat ggatacaagt
    25921 ggaagttttg taggaatttc aaactttagt aaatatattg aaaatcccac tcttatagca
    25981 tcatttaaaa actcaatttt tgtatctaca atttcatcct taatatcatt atgtttagcg
    26041 tttatatatt catatgcaat aacaagaacg aatataaggt ttaaaaactt ttttaaaact
    26101 atgggcatat ttccgctttt cgcaccagct atgctatatg gtatttcact tatatacctt
    26161 tttggaaaca agggaatctt tacaattata ggcatagaag taccactata tggtccatta
    26221 ggaataatta tttgtcaaat actgtttaca tttccacagg cctttttaat attatctgta
    26281 gcactttcga tggctgatta tagactttat gaagcagcag atagcttagg ggctagtgaa
    26341 tttaagaagt tcttcaaaat aacaattcct ggtataaagt attcattagt tagttcgttc
    26401 tttgtatctt ttatacttgc atttacagat tttggagcag caaagatagt tggaggaaac
    26461 tacaatgtat tggctactga catatataaa caagtggtag gtcaatttaa cataccaatg
    26521 ggagctactg tctctatggt aatgttaatt cctgtactaa tagcatttac agtagataag
    26581 atagcaagta aaaagcaagg gatgactata actgcaaagt ctatgccata taagattaag
    26641 gaaaataagt ttagagatag agtattttta atagcatgta gttttataac tttattaatc
    26701 tttattttga tatttgtttc agttataggc tcagttataa aattatggcc atatgattta
    26761 agctttacaa tggaacacta tacgtttaaa ggtatatcag gaaatggaat caaaacatat
    26821 ttaagcagtt taaaaatatc aattttaaca gcaatatttg gaactatatt tgtatttttt
    26881 agtgcttata tgatagaaaa agtggataag tttcctagac tgagacaaat atcttatttt
    26941 ttatcaatga taccaatggc attacctggt ttggctttag gtatatcgta tataactttt
    27001 ttcaattcag caagtaatcc attaaatttt ttatatggaa gtacaacaat aatggttata
    27061 gccaatatag ttcattttta ttcagtttgc tttataactt caaattcatc tttaaaaatg
    27121 ttggatagag agtatgaatt agttgcaaaa tctataaata ttccatttta taaggtgttt
    27181 ttttatgtaa cacttccaat gtccataaca tcaatacttg aagtggctgt atattacttc
    27241 gtaaattcaa tggttactgt ttcagcatta atatttttat atatacctca aactcaaact
    27301 gcatcaatat cgatactaaa gttagaagag atagggtata tagggccatc agctgctatg
    27361 gcagtattag tgtttttaac aaatataata gtaaaacttt tgtatgaatt gacaacaaag
    27421 aaattaaaaa ctaagacaca aaaatggcaa caaaaagaag ttgcatagag gaggtaaaaa
    27481 tgaaatttag gaaattagtc tctttaggaa tattatcaac acttttattg agtgtaataa
    27541 ctggatgtaa taatgcttca tcaggttcaa atttaaagtc taataataag ataaaaggag
    27601 agttaacagt ttatacagca attgaagaag atagtataga tacatattta actacattta
    27661 aagagaaata tccagatatt aaattgaatg tacttagatt atcagtagga gatataacag
    27721 caagattatt agcagaaaaa gataatccta aagcagatgt gttatggggg gttgcagcta
    27781 caagtttgat aattttagat gacaaagaaa tgctagagcc atacgctccg aaaggctttg
    27841 ataaggtaaa tcctgtattt aaagatgata agaaagttcc ttcttgggtt ggaatagatg
    27901 cttggatgac tggtataaca gtaaatacta aagaattaag tgataagaac ataccagttc
    27961 ctagttctta tgaagattta ataaagccag aatataaagg tcttatatct atgcctaatc
    28021 cagcttcttc tggaacagga tatttaacag tatcagaact tatacaaatt atgggtgaag
    28081 aaaaagcatg gcagtatatg gataaattgc ataaaaatat tggtgtatac actcagtctg
    28141 gttcagcgcc agctatatta gcagcttcag gagaatatcc cattggtata tcttttggaa
    28201 atagaggtat aaagttaaaa ggtgaaggtt atccagtaga agtagtattt ccaaaagaag
    28261 gttctggatg ggagatagaa tcaaatgcac ttgtgaaaaa agataatata aaagaagcat
    28321 caaaagtatt tttagattgg gctataagta aagatgcaat gaatgagtat tctaagaatt
    28381 ttgcagttac tacaattgac acgggaaatc cggtgccaga aggatttcca aagaatccat
    28441 tagaacagat gatagataat gatttaaaat cagcagcaag aaatagagag gctatactaa
    28501 ataaatggat agaaaaatat gatggaaaga cagaaaaaga gagctaagcc ttgcaataaa
    28561 atttagtaca aaaagcgcct agaatataag ttttatatct aggctctttt gatatattta
    28621 tttaaaatgc atatttctat ataaaaataa atagtttagt accttgatta aattaaataa
    28681 aaaccttaaa ataaagagat gtaaagaaaa actaaaaacg aataaaaggt gaatttatat
    28741 gataaaagaa ataatagtag tagagggtag agatgacgtt acagcagtta agagagcaat
    28801 agatgcagaa cttataacta caggtggatt tggatttcca aaaggtgtaa tggagcgtat
    28861 aaaagctgct aatgaaagac gtggtgttat aatatttaca gacccagatt ttgcaggtga
    28921 aaaaataaga aaaaaaatag catcagaagt tccaggatgt aaacatgcat ttctaccgag
    28981 agaggaagct aaaaaggatg gagatatagg tattgagaat gctactcctc aaagtataat
    29041 agcagctctg aataaagtta gaactgaaaa tacagaaaaa agagatgaat ttaagcaagt
    29101 tgacttaatt agaaatggtc ttataggtaa tgaagaagca tcacttagaa gagatgcact
    29161 tggaaaaata cttggaattg gatatggaaa tgcaaaacaa tttttaaata gattgaataa
    29221 ttatggagtt gaaagagaag aatttataga tgcattaaaa caaatctaaa cgtaatgttt
    29281 aatgtatgaa aaatatgtat ataaaataaa ttgtggaatt acggttaatt taagatgaat
    29341 tatttataat atacacctta ttttaaatca atgtaaatac atataaataa gtataattaa
    29401 taaaattaaa tatcaaaata agttaaaaag gagtaaataa tggatagact atcttcacat
    29461 aatgcaacaa aggaagtagt acaaaaatat aattttaaat tttcaaagtc tttaggtcaa
    29521 aatttcttga tagatagtaa tataattgat aaaatcttat ctggagctag aatcacaaga
    29581 ggagataata tcatagaagt aggacctggt ataggaactc ttactcgtga gatgggtaaa
    29641 atagcagaaa aagtagtggc tatagaaatc gatagaaatt taattcctat attgaaagat
    29701 accttgtcag atttagataa tacagaggtt gtaaatcaag atatactaaa agtagacata
    29761 caggaattag taaaagataa attaaatggt gggccagtta agcttgtagc aaatcttcca
    29821 tattatataa ctactccaat agttatgaaa tttttagagg aagacatacc tgtaacagac
    29881 atagtagtca tggttcaaaa agaagttgca gatagaatga atgctattcc gggtactaaa
    29941 gattatgggg cattatctat agctgttcaa tactattgtg atacagagat tgtggcaaaa
    30001 gctccaagac atatgtttat accacaacca aatgtagatt ccacagttat aggtctacat
    30061 gtaagagata aaagaaaata tgatgttcat aatgaagaca tattttttaa aacagtaaaa
    30121 gcatcctttg gacaaagaag aaaaactctt cttaattcgt tgggaggtct tggttttctt
    30181 aataaagatg aaataagaga agtattaaaa gaagctaata tagacgaaaa aagaaggggt
    30241 gaaactctta gtatagaaga gttttcagtt ctttcaaata taataaatac aaaagtatct
    30301 tctaaataga aggtactttt tttaattttg ttaacatata ttgtttagag aaactgtgtt
    30361 aaggggggat tgcagtgggt tctaaaagaa agtttaaaag agactatata atactagaag
    30421 ctaaagacat aaactttaga tacaaagaac gagtactgcc aaaagctttt gcaaaagttg
    30481 aagtaaatga tgaaaaagca attattgcat tatatgtaga aaatctaaaa tatgttaaag
    30541 atgggtataa agcagtagca ataaaagatg accatggatt aatagactta ggaaatataa
    30601 ttttaaatga acaaggaaga ggtgaatttg ttttagattt agaagattat gatgatgaga
    30661 taaaaggtat tgcattattg tatgaaagaa atataccttt aattggattt aaaggaaata
    30721 agcttgaaaa ttatgaggac atattatttc aagaggtaga ggaagaagaa tatgaagaat
    30781 atgaagagtt ggaagaagaa gacgaagaga tagaggataa tgaggaaagt gatagagacg
    30841 aaggtagtga agaagaatat attatagaag aatatgatga agatgagtat gaagactatt
    30901 gggaagatga tgaagatatt gacgaaggag agttaaaagc aagaacggaa gtagaagatt
    30961 ctggtgatga ggaaatagaa gagttcaata attataagga aatagaaaat tataataggg
    31021 ttaaagtaca ggaagaatat atagacatag aatatgatga ggaagaagag gaagaagaag
    31081 aagtttttga agtaaataga gaagaagata ggtttgtttc ctcaaaacct actaaatcaa
    31141 agaaagttca aaaagatcag aataatattg aaaaaataaa aagagctaat ggagtaagtc
    31201 aaggagagag tggaaataaa caaaccagta cattacttat gccaagacaa ataaaaaaag
    31261 gtttgaaatt atttaaagaa gtaaaacctt ttgtaacaga ttatatagat aagacaagat
    31321 ggtggaaaat agagataaat cctacaacat tgtgtggata tacaatgcct tatttaggat
    31381 atttaaacgt gttgaattac accatgtata gtgatgcagt tttacattca tataaataca
    31441 gacactattt atttggagtc cagtatgatg aatataataa gagaaaacat tatatttatg
    31501 ctatcccagg aaatagaaat gaacagccag acaatggaag cacaggattt ttaagatatc
    31561 aagcttgtga taatagaaca aatagtttag gatattggct atgttttata gattctagac
    31621 aaagaaatat agttaggtaa aaataataaa aatgaaaaaa tttagactca attcttattt
    31681 tactgaaaaa attaatgaaa tgtagtacaa aactttaaaa actattgata atatttaaat
    31741 attacactac aatatatctt gaaataccta ttatattatg gaggaaaatt atgataaacg
    31801 agcaaagaat tttaaatgag tttcttgaat tagtacagat agatagttta tctttaaaag
    31861 aggggaatgt tgctaaagta ttagttaaaa aattagaaga aataggttgt tcagtagtaa
    31921 tagacaatgc tggtgaaaaa gcaaatggag aaactggtaa tataatagct acattaaaag
    31981 gaaataaaga aggaaagaaa atattattta gttcacatat ggatacagta actccaggta
    32041 taggggtaaa acctatagtg gatgaagcaa atggaataat aaaaagtgat ggtactacaa
    32101 tattaggttc tgatgataaa gcaggtatag cagctatatt agaaggctta agatatataa
    32161 atgaaaataa tatagaacat actgatatac aagttgtatt ctctatatgt gaggaatgtg
    32221 gattagttgg agctaaaaat ttagactatg gaaaaataga ttctgaatat gcatttatat
    32281 tagatagtgg tggttctcca ggtgaaataa tagtaaaagc tcctgcacaa gatgtaataa
    32341 atgttaagat attaggaaag actgctcatg caggtcttga acctgaagct ggaataagtg
    32401 ctataatggt agctgccaga gcaatagaaa atatgaattt acttagaata gacgaagaaa
    32461 caactgctaa cataggaatt ataaacggtg gaacagctac aaatatagta acaggagaag
    32521 ttaatataat tgcagaagcc agaagtctaa aagaaaataa attagatgtt caaactaaac
    32581 acatggtaga gacttttgaa aaagctgcaa aagattttgg agctcaaatt gagatagatg
    32641 tcaatagagc atatacacca atagatgtta gtgaggattc tgaaataata aaacttgcaa
    32701 agaaggcttt ttcaaactta ggtatagaag gtcatactga atctacagga ggaggtagtg
    32761 atacaaatat attaagtaag aatggtattg aagctataac tttaggaatt ggtatgaaaa
    32821 atgctcatac actaagtgaa catatagcta taaaagactt atatgattct gctaaaatgg
    32881 tagtggagat aataaaggaa gcataaattt aaataatagt gtataatata tatatcgcct
    32941 agcttaagct aggtgatttt tcattttata gaagattgat aatctctatt gaaagtaaag
    33001 agtatacatt tgcatataag agagtgttta atttatgttc aaatgtaggt tcttaataat
    33061 atttagattg tttcataagg gaggaataaa tatggaaaca aggtatgaag aagcaaataa
    33121 aataacaata caatcaatac tttggaatgt agtattaaca ataattaagg ttatagctgg
    33181 tgttattggt aattctagcg ctatgattgc ggatggatta cattcagcat cagatattat
    33241 aagttctata ggagtactaa taggcaatta tgtatcttct agacctggag atagagagca
    33301 taattatggt catgagaaag cagagacatt agtatcattt gtgttatcaa tattgcttat
    33361 tttcgtttct ataacaatag gtatagaggc aattaaatct ttatttaact tagatgcatt
    33421 aagtgttcca tcaatattac cattagtagt atcagttatt tcaatcctga taaaagagta
    33481 tcaatataga ataacaataa aagttgctaa aaagataaat tcaccagccc taaaagctga
    33541 tgcttggcat cataggtcag atgctttatc ttcagtagct gcttttatag gtataggtgg
    33601 ttctatttta gggtttaaac cattagaccc aattgcgtca gttgtagtgg ctatatttgt
    33661 agctaaagta ggaattagta tacttataag ttctgttaat gaattgatgg atgtttcagt
    33721 tgatgaagaa gagataaaag aattaaaatt tattgtagca gatacagaag gtgttaaaaa
    33781 tcttggtgat ataaagacta gaaaacatgg agctatggca tatgtagatt tgactatatg
    33841 tgtggatgaa aatttgacag ttaagcaagg tcatgatatt gctaccaagc ttgaaaaaca
    33901 tataataaaa catatggaat ttgtaaaagg cataacagtt cacgttgaac catgtactaa
    33961 ttgccaagga aataagtgta ataattaatt aaaacttaaa aaaaagtgta aaaagttata
    34021 taattgtttt atgattataa actctagggg tggttaaatg agcaagaaaa gaaaactaaa
    34081 gaaaaaagct gcaatattaa taggagtagt tgttttcttt ataatatact ttatatcctt
    34141 tagaatagga ataaatatgg aaaaggataa aagtgaagtg ccaaagaagg tagaaaaaga
    34201 agaagaagat aataggtctt taaggactca aataaaagag aagaagaagg tttatatatc
    34261 agataaaaat atagaaaaca taaaaattga agaagatatg tgggatgaaa taaagttatt
    34321 tttctcagat tttaagaaag taagaaatac tacttcttct tacgaagcag tttatgaagg
    34381 ttattctgat gatggagtta aattttctac tgaccttaac ttttttagag tatatactgt
    34441 aaataaagaa gaatattata aagtaccagt tagttctaag gatgctttta agaaactttt
    34501 agatgagagc atatatactt cgtttgacct tttaagtcat tataaagatt ggaaagaggt
    34561 tactataact catggaaaag aaattaaaaa agttcataga tggaaatttg atgatttagc
    34621 acataagatg atttcaaaga gggttgtagg aaaagttcaa cctgagaaaa gtaaggaaag
    34681 aagtgactat aattttacta taaatataaa aggtgataat tttgatgtaa aagttgatac
    34741 aatgggaaaa gattatgtaa aagttacttc taagaaaaat gtatcttact atgaggttca
    34801 tacaagttta tttgattacc ttaaaaatga gatatttgaa attggaaaga aataagactt
    34861 taagaaggct atcaaattag atatttgata gcctaaatta ttttatatat tatttttcaa
    34921 ccaacaagtc tgcaacctta taaattggac cagcaccagc agttattact aaatcattat
    34981 ccttaacatt ttcacgtaag tattttacta tatcttcaaa ttcttttata tagatggcat
    35041 ctacattgtt ttgatataat ttctcaacca agtccttaga atgtatatct cctgggtctt
    35101 tttccctagc agcatatata tctgttatga taactttatc agcagcatag aatgcctctg
    35161 aaaattcacc taaaagagat tttgttctag tataagtatg tggctggaag atacaccata
    35221 aagttgattt ttttaatttt ttggcagcag ctaaagttgc ttttaactca gttggatgat
    35281 gtgcataatc atctactact aaagcattct tataataccc tttagtttca aatcttcttc
    35341 cgacaccttt ataaattttt atattttttc ttatagtctc taagtcaata ccagaaacaa
    35401 gagctgccat tatggcagaa gaagcattgt atatgttatg aagaccatat acagaaagtt
    35461 caaattctcc taaatctctt ccttcatatt ctattctaaa tattccatga ccactattgt
    35521 caaagtgaat atcttttatt acagcatcat tgtcagaatc tctgccgtat tttataatag
    35581 tagctttaac atcatacaat atgtcatcaa tattttcatc atcgccattt attatgaaat
    35641 agccttctgg gggtaataat tttccaaatt tgttaaaaga agctttgatt tcatctattc
    35701 cagagaaata atcaagatgg tcttcttcaa catttaaaac tatagatatc tttgggttaa
    35761 aattaaggaa actatctaca tattcacatg cttcagttat aaagtggttg gaattaccta
    35821 tcttaacatt accacctatc atacttaagt taccaccaac tagtatagtt gggtctaagt
    35881 ctgcatattc aaagattgta gataacatag atgttgtaga agtttttcca tgtgttccag
    35941 aaactgctat agaattttta tattccctca tgatttggcc taaaaaagtc gctctgttca
    36001 ttaccaattt atttttttct ttagcagcca caagttcttc attgtctgga tgaactgctg
    36061 ctgtataaac aaccatattt acatcatctg atatattatc ttttttctga ccaatataaa
    36121 tagttgcccc ttggtcccta agtttgtcta ataggtatga ttcgtttgaa tccgaacctg
    36181 aaacttgata acctttattg atacatattt cagctaatgc actcatgctg ataccgccaa
    36241 ttcctataaa gtgtatattc ataataaaac cacctttctt tttaattaag tcctacaata
    36301 tgaactattt ctgtggtata ataatataat gttcaatatt ttataattaa tatgcatata
    36361 atattatatg tattttattt ttgaatataa taaaacataa gtaatattat accacaataa
    36421 gaattgttat gcattagtta gtttaacgtt atataaaggt acttgtagga ggaaataata
    36481 atgaaattta aaagaacaga gagaattgga gcaatagtta aaatactgtc tgataatcca
    36541 aataaaatat atactttaag ttattttaca aatcaattta atgcagcaaa atcaacaata
    36601 agtgaagatt tattagttgt aaaaaatgta tttgagaagc tacatttagg taaagttata
    36661 actatttcag gagcagcagg aggagtaaaa tatataccta aaacttctat agcagaaaat
    36721 gcagagttct taatggaatt atgcgagaga atatgtgaca agtctagaat actatctggt
    36781 ggttttttat acttgattga cctaatttac gaccctacaa tagctgctaa gataggaaag
    36841 atattcgcat caaatattga gtatgtagat gcagattatg ttgtgacaat ggaaacaaaa
    36901 ggtataccta tggcacttat gactgcaaaa gctatgaatt tacctctagt tataataaga
    36961 aaagatataa aggtatcaga aggtcctaca cttagcatga catatgtgag tggaaacagt
    37021 tctaaagttg aaagtatgag tttgccaaga aaagctctta aaccagatag taaagttata
    37081 attatagatg atttcatgag gggtggaggt actataaaag gaatggtaga ccttatgaat
    37141 gaatttggtg cagaggttat aggtactgga gtattcatat ctacaacgaa tccttcagaa
    37201 aaaatggtaa aagattatat ttcgttgatt caattggatg ttaatggaga taaaatagta
    37261 gtagaaccaa acttaaagac ttttaaagat gaatatagaa atgaagattt agacgaagaa
    37321 gaagattcag aatttgaatt tgagatagat gaagattaat aaaaaaaata tttagaaaaa
    37381 tatgtaaaaa taaaaagagg atatccctag ttgttcatag aattatttaa aaaacagttt
    37441 atattaattt attccagcga taataatttt aatataaatt aatttctgtc aaaatcaaag
    37501 ggggatattt tggtatgaag ataactgacg taagagtaag aaaattaaca gaagaaggta
    37561 agatgaaatg tatagtttca ataactttcg ataatttgtt tgtagtgcat gatataaaag
    37621 ttatagaagg ccataatggg ctatttatag caatgcctag cagaaaagta ggcgaaggaa
    37681 atttcagaga tatagctcat ccaataaatg cagaaatgag acaagtttta gaagatgcag
    37741 ttttacaagc gtatcatgaa gcattagttc aatgggaagt agctgctgaa taataataaa
    37801 tatataaaat ggagagagcc cgaacattta ggctcttttt aaatgtagaa tttctattaa
    37861 aatatgtact ttttagtaaa aaagtgctat attattagtg ataatgtata tgttgtatac
    37921 aaattgttag ataaatgtat tataatgtat attgattaag agaataatac gaataaaatt
    37981 aaattagatt gaatggagtg tatcaatgaa ctttaaagct ataatccttg ctgctggcaa
    38041 aggaacaaga atgaagtcta aatacccaaa agttatacat aaagtatgtg gaaaagaaat
    38101 ggttaaccat attatagatg tttcaaaaaa atcaggggta aaagatactg tcgtgatttt
    38161 aggacatgaa gctgatgtag ttaaagaaaa gcttgcagaa gaaattataa tagccatgca
    38221 aacagaacaa cttgggacag gacatgctgt aaagatggct aaagaatata ttaatgatga
    38281 agatacaata gttgtacttt gtggagatac tccacttata aaagaagaga cactaaagag
    38341 actatttgaa tatcatatag aaaataaata tcatgctaca gttcttacaa caagagttgg
    38401 aaatccaaca ggttatggta gaataataag agataagaag ggtgaccttc ttaaaatagt
    38461 ggaacaaaaa gatgcaaatt cagaagaaaa gatgataagt gagataaact ctggaattta
    38521 ttgttttaat ggaaagagtc ttagagaagc actagatttg ctaaataata acaattcaca
    38581 aggtgaatat tatttaactg atactgctaa aataatgaga gataaaggat taaaagttgg
    38641 tgcatttgca ggttcaacta ttgaagaact tatgggcgtt aactcaagag tagaattatc
    38701 aaaggcagaa gaaattatga gacgaagaat aaatgaatct catatggtaa atggagtaac
    38761 tataatagac actaactcta cctatataga atctgatgtt atgataggca atgatactat
    38821 aatatatcca ggtgttatgt tacaaggaaa aacaaggata ggttcagatt gtataattgg
    38881 aatgaattca tctataacaa attcagaaat aggtgatggt acagaaataa aaaattcaac
    38941 tataattgat agtaaggttg gagaaaattc tactgttggg ccatatgcat acttaagacc
    39001 aaagagtgac ttaggaaata atgtaaaaat aggcgatttt gtagaagtaa aaaatgctat
    39061 tatagaagat ggctcaaaag catctcacct ttcttatata ggagatgcac atgtcggtaa
    39121 aaatgtaaat attggatgtg gagtagtatt tgtaaactat gatggtaaaa ataaatttaa
    39181 atcaatagta aaagacaatg cgtttatagg ttcaaattct aatttagttg caccagtagt
    39241 tgtagaagaa aaaggatata tagcaacagg ttcaacaata acacatgatg tcccagatgg
    39301 tgctttggca atagcaagag aaagacaagt tatcaaagaa ggatgggtag aaaaaaagaa
    39361 tcaaaaagac gaccaaagta agtaattatg tagtttatta ttttggctaa aaaatttagc
    39421 tcgaaattat tataaattat attcattagt attttaaaat tttcaggagg gttacataaa
    39481 tgaatactag cggaagcgag attaaaatta ttgcaggtaa ttcatcgaaa gagttagcac
    39541 aaaaaatagc tgactatata ggtgtatcag tactagattg tgaagtaggt acatttagtg
    39601 atggtgaaat atgtgtaaac atgaatgaga cagtaagagg ttgtgatgtg tttgtagtgc
    39661 aatctactaa cagcccagta aatgataact taatggagtt attaatctta attgatgcgt
    39721 taaagagagc atcagcaggt agaataacag cagttattcc ttactatgga tatgcaagac
    39781 aagacagaaa ggctaaggca agagatccaa tcactgctaa attagttgca aatttaataa
    39841 ctgctgctgg agcagataga gtattaacaa tggatttaca tgcagctcaa atacaaggat
    39901 attttgatat accattagac cacttactag gtggaacaat attagcaaat tattttaatg
    39961 aaaagaaaat agaagattta gtagtagtat ctcctgactt aggaagtgtt actagatcaa
    40021 gaaaatttgc taatacttta aatggagaag ttccaatagc tataatagat aaaagaagac
    40081 cgaaagctaa tgtatgcgaa gttatgaact taataggtga tgttaaaggt aaaaatgtta
    40141 tactattaga cgatatgata gatacagcag gaacaatagt taatgctgca aatgcactta
    40201 aagagtttgg agcaaaagat gtttatgctt gttgtactca tggtgtgtta tcaggtccag
    40261 ctattgaaag aattgctaat tcagaaataa gtgagttaat agttcttgat actatacaac
    40321 ttcctgaaga gaaaagaata gataagataa agataaaaac agtagctcct ttatttggag
    40381 atgctataag aatgatattc tctaatgaat cagtaagtaa attattctaa tttattgtat
    40441 ttatgagagt tgtttaaaag gatataaacc ttttgagcaa ctcttttttg attttataat
    40501 tatggaatgt tatttttttc ttgttagaaa ggtatatatt attgtaaaaa gagattatag
    40561 tttaaaatta tgtatattta agtaaaataa acttaataaa gggcatatta ttcaaaatat
    40621 tatgaatata aaaaatatta caaaaaagta ttgaaaaaat tcagattatg tagtattatg
    40681 taaatataaa taaagaaaga aagaggtgtt tccaatggga aggttagaag atgaacccct
    40741 aataattaaa tgattcagtc acaatctaaa gtgaatataa aaatctattg aaagtttatt
    40801 tataagaatt gaaaatagta tctattctat ctttagtgtt tgtgagaggg ttctggatta
    40861 tataagatta ctgtaaagaa gtaattttgc acaataagca tatctgtaaa tgaagagttt
    40921 cgtttatata atgattgtgg ctgaatcata actataatag atagaatgtt tataatagat
    40981 gattttataa aatactatat tgtaatagct tttagctttc aaataaatat tagcaaagga
    41041 tggaaatgac aatgataaaa ctaaatgata atttataaat atctccttac gatatataat
    41101 aattgtaggg agatgtttct tttttttgta gagtataatt tttctagaaa ttctgtttca
    41161 atatgtaaaa agttggtata tataaatagt ataaacagtg ttgctaaaat atggtagata
    41221 ttatataata taaatggata tgtatataca ttatgagtta tataatttga atttaataaa
    41281 atagaaacgt tgatttatgt tctgtaatgt gggcaccttg gagcatattg agttagtggt
    41341 gcaaccggct atgaaattgt atttatttat aaatactatt attttcatag ctttttttat
    41401 ttaaaaaatg gttatatgtt agaaataaat ttggttagta cgtttaaata attttactta
    41461 gatttttaac cagatatatt ataagtaagt attaattaaa aaatttaagg gggaataaaa
    41521 atgaagttaa aaaagaataa aaaaggtttc actttagtgg aattattggt agtaattgca
    41581 attataggta tattagcagt agtggcagtt ccagctttat ttagtaatat aaacaaggct
    41641 aaggtagcaa gtgttgagtc tgattatagc tcagttaaga gtgcagcatt atcttattat
    41701 tcagatacta ataagatacc agttacaaca actgataaag ctggtttaac tattttagag
    41761 acttatatgg agtctttgcc tgataaagct gatataggtg gaaaatataa attgattaaa
    41821 gttggtaata aattggtatt acagataggt acagatactg aaggagttac attaacagaa
    41881 gcacaatcag caaaattatt gagtgatata ggtaaagata aaatatatac aggtgttaca
    41941 ggagataatt ttggagacga attaacagat actacaaaaa tagataataa agctctatat
    42001 atagtactta tagataatac tgtgatggac tcaacaaaat aattaaaact atatttttat
    42061 aaagaatatt gtaaatttaa tgaaaaatat aatataaaag acaggaagaa aatcttcctg
    42121 tttttttata ctattttctt taatgttcaa ttatgaatga tgatataatt gagatagtaa
    42181 aggagtgaaa cctgtggcta aaaaagttag aataggagac aaactggtcg aaaaaggata
    42241 tataacagaa gaacagctta aatgggcact atcagaacaa aaaaacagtg gaaaaagact
    42301 aggagaattt ctagtacaag aagggcttat agatagtaac ttactaataa gtgtattaaa
    42361 agaactcttg gatatagaaa gtatattttt agaagggaca gaaatagaca ctttagctac
    42421 aaaaatggtt ccagaaaata tatgcaaaag atatactgta tttccattta aaattgatgg
    42481 aaataaaata tgtctagcca tgtcagaccc acaagataga gaagcagttc aagatgtaag
    42541 gcgtatgtct ggtaaagacg tagagatatt tatatcaagt acagaagata taaacaaagc
    42601 aataggtcat gcttatgcac attcagaaat aaataaggca atgactgagt acaacaaaaa
    42661 tagaactggt ggagtaagag aaacagtaat acttgaagaa gatgtaaatg ctgctccaat
    42721 agtacgatta gtaaataaca tactagaaaa tgctgttaga atggaagcaa gtgatataca
    42781 tatagaacaa agtgaaaatt acatgcgtgt taggtttagg atagatggaa tgttaagaga
    42841 atatatgagg atgaactcag caccatataa ggcagtaatc agccgtatca agataatgtc
    42901 agatataaat atatctgaaa agagaatacc acaggatggt agaatctatt taaaagtgga
    42961 taataaaccc atagatttta gggtttctac aatgccaact aacagggatg aaaagatagc
    43021 tatgagggtt cttgataaga gtaattttat ggttagtaaa gaagtactag gaatagacga
    43081 acatggctct aagatatatg atgaattgat aaacactcct tatggtctta tattggttgt
    43141 tggccctact ggaagtggga aaaccactac attgtattca atgttaaatc aactaaatac
    43201 agaaaataga aatctattaa caatagaaga ccctatagag tatgaattac ctggtgtaaa
    43261 tcaatctcaa ataaatgaaa aggcagggct tactttcgcc agcggactta gagcttttat
    43321 gcgtcaagac ccagatataa taatggttgg agagataaga gatactgaga cagcagaaat
    43381 agcaattaga gcttctctta caggacattt agttttaagt acattacatg caaatacagc
    43441 agttggagca atttcacgtc ttttagatat ggatgtggaa agttttttaa taacttcatc
    43501 tgttttaggt gtaatatctc aaagacttac acgaaaaata tgtgagcatt gtaaggtttc
    43561 atatgaagca gatattggag aaaaaaaggc tcttggtatt gatgtaaatg aatcagtaac
    43621 tatttataga ggaaaaggtt gtgaaaggtg taataatact ggatataaag gacgtctagg
    43681 tatatttgaa atgcttgaaa ttactccaga aataaaagag ttaatagatt catctgcaaa
    43741 tcaaagagaa attttaaaga tggctagaaa acaaggtatg gttagcttaa aagaggatat
    43801 agttaaaaaa gttttaaatg gaaagacaac agtagaagaa atgattagaa taattttgat
    43861 gactgattaa aggatgatat tatgaaaagt tttaaataca cagtaataaa agaggacgga
    43921 aaaaagcaaa ctgatgtgat tgaagccaac gattttaatg aagctagaaa tcttcttaga
    43981 aagagaaatc ttagagttat tgaaatcaaa gaaagcaaaa ataaaaatat aagattatct
    44041 agtagaaaga gaaaaaaaga cttaggagct gaccagataa gccacttttg tagacaattt
    44101 gctattatag tatcttctgg tataaatagt atttctggat tagaaacatt agctagaagg
    44161 tcaactaaca ttacattaag agaagaaatt aatcgtatag tagcagaaat aaaagtaggt
    44221 tctactattg cagattcaat gctttcatca aaatcaaagt ttccaaagtt acttggtgct
    44281 atggtagcta caggtgaagc tacaggtaaa ttagatgaag tattaaaaag tatggcttca
    44341 ttttatgcaa gtgaacacag ggttaaacaa aagcttagaa atgctgcaac atatccatta
    44401 atagttttga tttcttcatt tataatgatt tttatattta caacatttat ggtgcctaag
    44461 atgattaatt caattacaac agtaggagca actcttccac ttataacaag aattgttatg
    44521 gggtttggta tgtttatgaa gaagttttgg ataatagtac ttttagttat tatattattt
    44581 atctatcagt ttaaaaaata tctaaaaacg tcagttggaa gggctcataa agatagagtt
    44641 ataaataaga tacctgtttt aggaaaagga ataaattgta tggtagctac acgattttca
    44701 agagcattgt atctatttgt atcaacagga tacccattag ttcaagggct tgattatatt
    44761 atagatagtg taaataacac tatggcagag aagattttag catcagctaa agatggaata
    44821 acaagaggag aaggcttagc agaaaattta gagagatata cgtattttga ctctgtgttg
    44881 gtacagatga tagctatagg ggagcagaca ggggaattag agaatataag tagacagatg
    44941 gcagaatttt atgagtatga atccgagatt tatttaaata ggatggcctc aatgatagag
    45001 cctgttttaa taattgcagt tggtattata gttgcgatac tggttgtatc aatattcatg
    45061 ccaatgctta gtatatatga tgccatgtag gagggaaagg acaaatgaac aaggtttatg
    45121 tatcatatta tggcgattct atttccatag ttgagggcag atataaacac gataaggata
    45181 agttttatgt aaaaaatttt aatgtgtttt caatagagga tattgcacaa gatttttcta
    45241 aggaaaagta tgctctattg agatacgcat tagaaaatgt taagttaaaa tcaagacatg
    45301 tagttttttg tttaaataca agagatgtaa ttttaaaacc ccaaaaactt cctaatatgg
    45361 acaaaaagga tttagacgga tttatgaagc tagagatgga cgaaatgatg gctttggagt
    45421 cagatgaata tgtattttcg tatgaagtat ctagtgaaac acctgataat tcagatggcg
    45481 atgaatcaag cttaaatctt attattggag ctatacaaaa ggaagaggta aatgcaattg
    45541 tagagataat gcatgaattt gatttagtat tagatagaat agatacatta tcaacagctt
    45601 acttaagaat gcttaaaaat ttagactaca atgatataat ggtaaccaat ataagtgaca
    45661 atagcacaat tataaatata tataagaaag atactttatt tattagtgat aatataccta
    45721 taaagataac tgctaaagat atggacatgc aattattaaa tgtagtagaa gaatcaaaag
    45781 gtcttatgaa ttactattcg tcaagaaact ttggtaaggt tacggatact atattaatat
    45841 taggaaaaag atattccaat aaattaattt atgaaacttt tagctctgca ttttcaagct
    45901 atgtttctca aggccttact gagataatgg atatatctga tatgataact ggagatatag
    45961 atgaagatga tataaattca attgtagagc ttttaggaag tatgatagaa cctaaaggga
    46021 aaagagattt tgaaaatata aactttttac caatggatat acttagaaaa cagataaaag
    46081 ctaaacaaat gaaaaacata ctgaaaattg ctccaatagt tattttgatt cttgctatac
    46141 cttatttatg tttaattttt tcaaataatt tagcaaataa ggaacttgaa aatgttaatg
    46201 gtgaaataag aaatattgaa tctgcatatt atcagattgg aaatatagaa aaaatgatac
    46261 agagtaaaag cgaagaaata aaggtatatg atatgttaat tgggaaaaag gtaaagtggg
    46321 aaaatttatt ggatgatata gataaaaata ctccaagtaa agttgaacta acaagtttat
    46381 caacaactta tcaaaatctt ggaactaata ataaagctga taattcaaaa agtaataaga
    46441 ctacaacaga taaatcaagt aacaatgaaa caaaatcaag tacgaaaagt gatagtaatg
    46501 gagataaaac agataatgat ttaaatgaag ataagactac aaatgtgtca gaagcattaa
    46561 ctggaaatag tgagactaat agtaataaca cggataaaga tgataaaact ccattgtatg
    46621 ataagatacc aaatgttata aatatagaag gaaatgctaa agattcctct tatgtaggtc
    46681 aatttttata taaattaaag ggattatact atttcaagga tgttaaatta catagcataa
    46741 aaagtaatgc agaagattct aactatacat ttagtatgac attatacctg aaagaaggtg
    46801 tattaactaa tgaataaaga tatatttaaa aaagatataa aagatatatt taaaatggaa
    46861 gttagtctaa aagggattct tataaaggtt ataattttat tagctatttt atcatatggt
    46921 tattttggac tttaccctca atatcagaaa tatattgcta caaaaaattc tgtaaaacag
    46981 gctactgaaa aattaaatat atataaagag aaaactgcac ttatgccaaa atatgaaaaa
    47041 caacttgagg aagttgaaag tgaattaaaa gaaaaaagca aaaatctttt atatgatatg
    47101 caagatggtc tttttttaat aggtttagat aaaaaaatga aggcttataa tattgactta
    47161 accagttatg acgttggaaa tgttaaagaa tacgaacatt tttatggtat atcaacaaca
    47221 ataagtgtta gaggtgatta tagaaatgtc aaaaaattaa tggcttattt agaagaacaa
    47281 aaaaatgtta ctcaaatact agattataca atgacttcat atatagaacc agaaaaagaa
    47341 gaggaagaaa caacaaacaa taaggattta attaaaaatg tgaacataaa taaagataca
    47401 aaaatatact gggtggaagg cgaaaataag tggcatttat ataaggattg tccattgata
    47461 aaagagggag agattataaa aaatgacaaa cttttagata ggtctactaa ttatctatgt
    47521 aatacttgtg tacttagagc tgcaacagaa aaagaagcaa aaaaagaagt cgtagctcca
    47581 aaggcagaag gtgtagtaga tgctacattt aaatttataa tgtacactaa agagaatact
    47641 acaatgatac ttgatacaga taatccatct tcatggagac caggaaaata taatccattt
    47701 aagtctagtg cgaaataaag ctaagtaagc tttaaagata ggtgatgagt ttgtacaaaa
    47761 ataatgaaaa aggtcttact ttattagaag taataatagc tgtttttata ctgacaatag
    47821 ttttaagtat ttcttataaa gtgttcaatg gtataacatc agcagtaaaa aagcaacaga
    47881 ttattacaga tgctcaagta aatattaatc taattaataa gtatctaaat agagatttgg
    47941 aaaactgtaa agagctaact aaaactggtt caggtaataa ttatgaatac aatatagaga
    48001 tgccagataa tgttgtaaaa tatgaagttt ctatagaaac taaaaaaaat acagaggtat
    48061 attctgtaac gagaatccaa aacaatacaa ttgatacaga aaatgaagtt agagaagaga
    48121 taatctataa tcaaccacta gttcaaaata ataaagaaat gaaggaaaca ccatttaaaa
    48181 tagaaaagca aactggtaaa tctatttata ctgtaagtat atactataat gaatcggtgc
    48241 aagaaagtca taaaaatagc aatttaaata acaaaactta tacatttgat gttatgtcaa
    48301 gaatagggta ataagaattt attaaaaaat aagtaggttg ataaaatatg agtaaaaaga
    48361 atagtgaaag aggattttcc ttaattgaag tgttagtagc tatggctatt atgggaattg
    48421 tactatttgc attttttaat attatcaata ctaataacaa agcaaacact aaaaatgaca
    48481 cagatataac ttccttaaac tatgtccaaa gtgaaataga aaatctaaga gaaaagataa
    48541 aaagtggaga atttgatttt gatagtttag ataaactaga agatggaact gtcgtatatg
    48601 aaaaattaat agataaatca aaaaaagttg tatatgataa agttcttagt gaaggtgatg
    48661 tgagcttata tgatactcca tatgaaaaga ttacaacaat aaaagatgaa gatggtaatt
    48721 taatcgacaa aggaaatatt acaaataaga taaagactat tgtagaagat aaaagtggtc
    48781 agatatataa aatagctgta actgggaaaa gcatgaatga ctattcaagt aaaaaagagg
    48841 ttaaaattgt aactgaaata tttaaagata aataatttta cttgggggtg agattttgag
    48901 gaagtggaat aaatttaaaa gtgaaagagg ggcagcttta gttttagttt tggttgtagt
    48961 agcattgctt tctattgttg gattgatatt ttcaaatcag atagctaata gaataaaatc
    49021 tacaaagact actaatgaag gtatacaagc aaagtattta gcagagacat gtgtggaaaa
    49081 tagtattgat aaagcatatg aaaaattgta tgatgagctt gagaaaatgg ataatgagtt
    49141 taaaagtgaa aatcaagaaa aatccatatc taggtcaaaa ttaagaaata tatcagatga
    49201 agattttaat aatcaagatg aggaaaatat tgaagcagaa agacttggat atatgaataa
    49261 tataaatttc tatttaaata aagcttcttc agacttggaa aaagctagta tggaattgaa
    49321 aaagctatat gatttagata tgttggacta tagagacatt gaatatgtag atgcaaatat
    49381 tatttcacat agaaattcta tcttagaaat ttgcaagaat tatacttctg gagatattag
    49441 taaaataaat gaatatattc tgaaagaaga tatagactca actacattga ttgaggcaaa
    49501 gttagtgaat aatgatattc ttttaaaaaa gtttttagaa gaaaataaaa ttgaaaatga
    49561 acatttaaat tcagcctttt cacatactta taaggcatta gataacattt ctttggcgat
    49621 gcaaaatatg attgagtata gacatacgtt tcatatagat gagccaaaag tagaagtatc
    49681 taatgggatt ccagactctc aacaatatta tgaactaata caaaatccta taataaatag
    49741 tatggagtat agctggaata gtaaatggga tacattagaa aacctattgg aaattttacc
    49801 aaatcaaact caaggattta attctttaag agttcatttg agaaataatg taagaaaatt
    49861 tgagaagtta agcgataata tatctagtgg taaaaaaaat acagcaaaaa atttcttaaa
    49921 gtataaagag ttattgtatg aaatatcaga ccaatgtaat caactaaaaa gtatgtctta
    49981 tgagaaaata cctgttaaat atgataacat ggctttgata acaacttttg actatataca
    50041 aaatgagctt ttagcagaga taaaatgcag attaaaagaa ttaaaaccac aagaaattga
    50101 taaaacagaa ggtattacta taaaaatacc tttttataag gctgactacg acatgacaaa
    50161 agaaggatgg cctaaattaa aagaaaatgg ttcaggggcg gagttaagct taatggtaac
    50221 tggtgataaa aatggaataa aagaagtaga agttacagat ggtaaaaaaa atattattgg
    50281 tttaggtgtt gaagaaaatt caaattcaaa gtataaggtt gacgccattg taaactttaa
    50341 tctaaatata gatacaaatg tagttggaaa ttatgatata aaagataaaa ttttgattaa
    50401 tcatgatata agttcataca aaaaagtaaa ctaaatataa gaagcaactt agtataaata
    50461 aataataaaa taattttatt atttactact aaaaaaataa gtaaactaat agaagatatg
    50521 gagagtaaat attatgtata tttatgattt attagagcaa ggtataagac taaacgcatc
    50581 agatatacac ataacagttg gaacaaatcc tgtagctaga gtaaaaggtg gatttgtaaa
    50641 actaagtgaa caaatattga catcagaagt aacaatgcaa atggcaaaag acatagcagg
    50701 ggaatctatg tttaaagtaa tagaagaaca tggagaagct gatttttcag cttctctaaa
    50761 aacaggagaa agatttaggg taaatgcata taggcaaaaa ggaaattacg caatagcaat
    50821 aaggactata acagcagaaa ttccaacatt tgaaaaatta ggccttccag agagtataaa
    50881 atcttttact gaaaagcata aaggattagt tttagttaca ggtccaacag gaagtggtaa
    50941 aagtacaaca cttgcaagta tgataaatat aataaatgaa aaacaacaaa aacatataat
    51001 tacacttgaa gacccgatag aatatgtaca tcatcataaa caaagtttag taaatcaaag
    51061 agaagtagga actgatacag aaagttttca ttcagccctt agagctattt tgcgtcagga
    51121 cccagatgta atactaatag gagagatgag agaccctgaa actgtttcaa tagcattaac
    51181 agcagcagaa acaggtcatt tagtattttc aacactacat acagtagggg cagctaagac
    51241 aattgataga atagtagaca tgtttcaacc atcccaacag caacaaataa aaacacagtt
    51301 atctacagtt tgtgaaggtg tggtatcaca gcagttactt cctacagcag atgggaaagg
    51361 cagaatagca gcaattgaat tgatgtttgc tactccagca ataaaaaacc tgataagaga
    51421 aggcaaaaca tatcaaattc caaacatgat acaaactgga gttaaagtag gtatgaaaac
    51481 tatggaccaa gatttaatgg aactttataa aaatggaaag attacaaaag atatggcact
    51541 tagtaggtgt actgaccaag agtttatgac aagaatgata ggtggagtaa actacaatgg
    51601 atattataat cgttaatcta tatgtattta tagtgggtat agtgtttgga agtttcttta
    51661 acgtctgtat ttttaggatt ccagaaggta tatctatttc tagaccacct tctcattgta
    51721 tgagttgtaa tactagacta aagccaatag acttaatacc agtgctaagc tatttaatga
    51781 gtggcagaaa gtgtagatat tgttatgaga aaatttctag tagatatgct atagtggaat
    51841 taattacagg acttttattt ttaacagtat ttatgttata tggaatatct acatcaacta
    51901 tttattattt ggttcttgtg tctttactga ttataattac atttatagat attgaccact
    51961 ttataatacc agataaaata ttggtttttg gagctatatt ttctatgatt tttaaccttt
    52021 tatttaaaga aattccagtt aaggattcaa ttctaggtgt ttttatttgt ggaggaagtg
    52081 tctggattat agttcttttg attgaatttg taataaaaaa agagtgtatg ggtggaggag
    52141 atatcaaact atttgcaatg ctaggttttt acatgggtgt taaaaatggt cttttgacag
    52201 ccttactaag cgtttatgtg ggagcagtct atggaatctg tgtaataatt ataagtagaa
    52261 taaaaggaaa ggaatataat tctgttatac catatggacc ttttatatct attggagcat
    52321 taataacaat cttatctgga aagcaattac ttgaacttta tttttctatg gttatataga
    52381 tgatagtcaa gttaaataaa gttttaattt aaaaaaatga attaaagtat ttaataagga
    52441 caatattatt attaacccta ttactaaagt gctacaaact atggagtata taataataat
    52501 ttccttattt tttgcacatt tgataaataa atctctatgt gttttttgtg atagagaaaa
    52561 gaaaaattta tataatacgt tttttattta cataataact gtagttttat ctgtattaat
    52621 atatctaaaa tttgggatta gtgtagaatg tgtacaatat atggttttaa ttccattttt
    52681 aataattata tccattgtag attactacac aatatatgta tatgatataa caatagttag
    52741 tggtataata gttcaaggta taattttttt ggcctttttc aatatagttc aatttgatta
    52801 tataaatcat atatttggac tattgatagg ctttattata ccttatatta ttgctaaact
    52861 aacaaaagga ttaggctatg gagatgtagg tctctatagc ttatgttgct ttgcattggg
    52921 aaataattat gggttttatg tgatagtttt atcatttatt ttagcgtttt tgttttttat
    52981 tattttatac ataactaaaa tatttaaaga tgtagatata agaaagcaaa ttccttttac
    53041 accttttatt tccttgtcaa caattttaat aatatttaca gagtataata tatttaattt
    53101 ttattataat ttgttataca aatttatata acaggaggta agaaatgtac gtagtagtag
    53161 ggttaggtaa tccaggaaag aagtatgaga agactagaca taacgttgga tttgatgtta
    53221 tagatattct tgctaaagaa tacaatatta gtgttactaa aataaagcat aaagctttga
    53281 ttggtgaagg gagagtaggt actgaaaaag tattattagt taaaccacaa acttatatga
    53341 atttaagtgg agaaacatta atagatatat ataaatatta taaggttgat ttaagtaata
    53401 tagtagtagt atatgatgat atagatttag aagttggaaa gatacgtata agaaaaaaag
    53461 gaagtggagg aactcataat ggcatgaaat ctataactaa gtgcctaggt tcaaatgact
    53521 ttccaagagt gagagtaggt gtatctaaac cagaagctgg tcaagactta gcagactttg
    53581 tactttctag atttagaaaa gaagaatctg ataacataaa tgaagcatta gaaaaagcgg
    53641 cagatgctat tgactcaata ataagagaaa atatagatat gtctatgaac aaatataatg
    53701 gatagtgaga gggagattta aatgaatgat gtttttttat atcctttgca aaattcaaaa
    53761 gagtataaag atataataaa ctgtataaaa aatacaaaag gctcattatt ggttaatgga
    53821 cttttaccag tacaaaaacc tcatatatcg tattctatat ttaatgattt atcacgacaa
    53881 atgattttta taacgagtag tgatttagaa gcaaagaaag tatacgaaga tttaagtttt
    53941 tatatggaag ataaagttga atatttaggt tttcaagata tttattttta tcacttggat
    54001 gcaaaggaca gaaacgaaga agcgaagaaa ttaaaagtat tgttaaaact agcaaataaa
    54061 gaaaaaatca ttttagtaac ttctattgag gcagttttaa gaaaatacat accaaaacaa
    54121 gttttgctcg atagtgtatc tcattataag gtgggagata gcttagactt agaaaagtta
    54181 actgagaaat tagtttcatt gggatatgaa agagtttcaa aaatagaggg gtttggtcaa
    54241 tttagtataa gaggtggaat tattgatgta ttttcacttg aatatacaaa tccaattcgt
    54301 atggaattat ttgatgatga gatagattcc atacgaactt ttgacgtata ttcacaaaaa
    54361 tcaattgata aattgcaaca attctctata actccatcta gggaatttat ttatcccgaa
    54421 aaaactacag atgcattagt taaattaaaa aaagaaacaa ctaaaaatac tgatgaaggt
    54481 acatttcaaa atatagatta tatatcaagt aagacttatt ttgaaggtgt agagaactat
    54541 atagattata tttatccaga agaaaacaaa agtatattta cttatttagc agatgatgca
    54601 atagtattta ttaatgatat aacgagactt aaagaaagat gcgaaaatta tataaatgag
    54661 tttagagaaa attataaatt aaatcttgaa agaggtctgg ctattaaaaa ccaaggtaaa
    54721 ttgttatatc actatacaga tttagagtac ttagtaaaag acaagtctgt ggtattaaac
    54781 tcgctattgc caaagtctat aaataacttt tctataaaat ctataataaa ttttgaaagt
    54841 agagaagttc ctacatttaa tggaaaggta gatttgcttg tagaagaatt aaatcggctg
    54901 aaatataatg gatacaaaat aattttagca acaaatacct tagaaagagc aaataaatta
    54961 ggaaaagatt tattggacaa aggcttagaa acgaccattt ctaaagatag agatattgaa
    55021 attaaatctt cacaagttat aattgtacct gcacacataa acagtggttt tcagtataaa
    55081 tctataaagt ttgttgttat aacagataac gaaatgatag gtgtttataa aagagcgtct
    55141 aagactagca ataaaaaagt taaaaaggga aagaaaatag aatccttttt agatttaagt
    55201 gttggagact atgtagtcca tgaaaatagt ggtgtaggta gatacacagg aattgaacaa
    55261 attacagtca atgctattaa aaaagattat atgaaaatag tatatcaagg tggagataat
    55321 ctatatgtgc caatagacca gatggacaaa gtacaaaaat atattggtgc agaagtagaa
    55381 aaagttaagt taaataagct tggaacaaat gagtggacga aagcaaaagc aaaagttaaa
    55441 aaagaaattg aagatatgac aaaagacttg attgagcttt atgcaaaacg tgaaaaaata
    55501 caagggtata agttttcaaa agatacacct tggcaggcag agtttgaatc gttgtttcca
    55561 tatcaagaaa cagaagacca attaaaggct atagaagaaa ctaaaaaaga tatggaatca
    55621 agtaaggtaa tggataggct agtatgtgga gatgttggtt atggaaaaac agaggtagct
    55681 attagaagta tttttaaagc ttgtatggac caaaaacaag ttgctgtatt ggttccaaca
    55741 acaatattgg cccaacaaca ttataataca ttcaaagaga ggtttgaaaa ttatcctttg
    55801 agagtagaag ttttaagtag gtttaaaaca ccaaaacaac aaaaacagat tattgaagat
    55861 gctaaaaaag gattagtaga tattttaatt ggaacacata gaataatatc caaagatata
    55921 aatttaccaa acttaggtct tgtagtcatt gatgaagaac aaagatttgg agtaaaacat
    55981 aaagaagctt taaagaaaat taaatctaca gtagatgtac ttacactttc agcaactcct
    56041 ataccaagaa cattacatat gtctttaagt ggaataagag acatgagtgt tatagaggaa
    56101 cctccacaag aaagacatcc tgtaataaca tatgttacag agagtaagga aagcgtaatt
    56161 caagatgaga tagagagaga attaagtaga ggtggacagg tattttttgt atacaataga
    56221 gttgaacaca ttgaagaaat ggcaagtatg attcaaaaac tcgtaccaga tgctagagtg
    56281 gctgttgcac atggaagaat gacttctaaa tcattagaaa atataatcct aggattttta
    56341 aataaagatt atgatgtact agtctgtact acaataattg aaactggtat ggacatatca
    56401 aatgcaaata caatgattat atatgatgca gataaaatgg gattggctca actttaccaa
    56461 ttgagaggta gggttggaag aagttcaaga caaggatatg catatctttt gtatgaaaaa
    56521 gataaaactt taagtgagat agcggagaag agattaaaag ctatcagaga atttacagag
    56581 tttggttctg gttttaaaat agcaatgaga gaccttgaaa taagaggagc aggaaatatt
    56641 ttaggttctc aacaacatgg tcatatggca gttataggtt atgatttgta cgttaaaatg
    56701 cttaatgatg caattaaaaa agtcaaaggt gaacctattg tggaggaaat tgatgttgaa
    56761 atagatttaa gtgtaaatgc atacattcca gataattata tcaaagatga gttgattaaa
    56821 attgaaatgt ataagaaaat agcttctatt gaaaacaaag aagacatgtt ggatatacaa
    56881 gaagaacttg aggatagatt ctctgatata cctaaaccag tccagacact tcttacaata
    56941 gcttatataa aatcgttatg taagatatta aaaatagaaa agataagaca attaaaagat
    57001 gaaatattat tagttccaat aacaaagtat agaactaaac agaaaatagg ttataatata
    57061 gttacagaat tagaagaatt attagaaaag atgtgcaagg taaaataact tgtaaattta
    57121 agaagggatg ttttaaattt gaaaaaggta ataacattgg taatagctat gattttggta
    57181 gtatctgtga ctgcttgcag ttctagtaaa ggagaaactg tggcaacagt tgaaggtaca
    57241 aagatatcat cagatgaatt taaaaaaact atagctcttt ataaagattc tatggaacaa
    57301 acttatggaa aagatatatg ggataaggaa gttgaaaagg gtgtaaaata caaggacaag
    57361 tttaaagatt taattcttga ccaacttata actacagaag taatatattc tcaagctaaa
    57421 aaagataact tacttcctaa aaaagaggat gttgaaaaaa gctttaaaga attaaaagac
    57481 gctatgggta aagatgaaaa atataaagaa caacttaaga aattaggtat agatgatgag
    57541 tttttaagag accaacaaga gaaagattta gcaatgcaaa actatcaaag taactttgct
    57601 aaaaagacta aaatatcaga tgaagaaatg aaaaaatact atgatacaca taaagatgaa
    57661 tttaaaaaag atgaggtaga agcttctcat attttattga aaacagtaga tgataataac
    57721 aagccacttt cagataagga aaaagctgaa gctaagaaaa aggctgaaga ggctcttaaa
    57781 gaagttaaat caggtgagga ttttgcaaaa gtagcaaaaa aatattcaca agatacttca
    57841 gcaagtgatg gtggtaaatt aggattcttt tcaaggggtc aaatggttgc tgaatttgaa
    57901 gatgctgctt tttctatgaa aaagggtgaa gtatctgatt tagttgaaac tcaatatgga
    57961 taccacataa ttaaagtgac agacagaata aatgagcaaa catcatttga agatgctaaa
    58021 gaaactataa aagaccaact gttgaaaaat aaatatcaag aacaaataga aaaattaact
    58081 aaagaagcta aggtagaaaa agatgaaaaa gtaataaata aaatcacaat ctaagactta
    58141 aaaaaagagt aatatgctta aaaaagctat atctggataa gatatagctt tttttgtata
    58201 tttttcttaa caatggtaaa aataaactta aagtaattta tggagggatt aaaaaatatg
    58261 aaagcaacag gtatagttag aagaatagat gatcttggaa gggtagttat cccaaaagag
    58321 ataagaaaga cattaagaat tagagaagga gaccctttag agatattcac agcaaaagat
    58381 ggagaagtca tacttaaaaa atactctcca ataggtgaat taaatgaatt ttcgcaagaa
    58441 tatgctgaaa cattagctga agtactagga tatggagtgt tgataacaga cttagattct
    58501 ataatagctg tgtctaagct tcctaaaaaa gattataaag aaaaaagtat aagtgatgag
    58561 ttagaagcaa taataagtga aagaacagta aaatattcaa aagataaaaa cattttacca
    58621 ttattcaagg aagaccaaaa agaatatact agtcaagtta tcatgcctat aattagtgca
    58681 tctggtgact gtataggttc aattgtagtt gtttcaaagg ataaagatac aattgcagaa
    58741 agtgaagaaa aatctttaaa aattgctgct aactttttag gaaaacaagt tcaataattt
    58801 tatcataaag accttttaca tgaaggtctt ttgaagtttt tgtgtaaaat attgaatata
    58861 gcattaaaaa tatggtatat taaagtttgt tatataaaca gtatggaggt tatgttatga
    58921 acaataacaa aaataaagac tcctttctaa aaggagccct tatacttggg ctagcaggtg
    58981 taatcgtaaa aataatgggt ggatttttta ggattcccct tggaaacatg attggttcag
    59041 aaggaatggg atactatcag gctgcttatc ctgtgtatac tctattttta acattagcta
    59101 ctgctggatt tccaacagct gtggcaaaat tggtttcgga aaaagttgca attggaaatt
    59161 ttaaaggtgc aaataagata tttaaggtat cacatacagt tttattcatt accggtataa
    59221 tatcattttg tatattattt tttggagccg actacatagt aacaaacgta atgaaaaatc
    59281 caggtgcgtt atactctatg aaagccattg ctccagcatt actatttgtt cctgcaatgt
    59341 ctgcatatag aggatatttt caagggagac aagatatgac taagattgct gtgtctcaag
    59401 ttgcagagca attttttaga gttgtattag gtcttacttt ggcttacttg cttatgaaga
    59461 gtctaggtca gacttttggt gcagcaggtg ctatatcagg ggctacaata ggttcaatag
    59521 catctatgct ttatttggtg tttgcttata tgctagggag aaaagagcgt agagcagaga
    59581 tagatgcaag ccaaagattt aaagatgaaa gagtgtctta tatttttaaa aagcttttaa
    59641 ctgttgccat tcctataaca ataggagcat cagtaatgcc acttgtaaat atgatagata
    59701 atgttattgt aataagaaga cttatggaag caggctttac atacaaagtg gcaaattcca
    59761 tgtttggtca attaacaggt atggcaatgg ccacaataaa tttaccagca gtcataacaa
    59821 ctgcaatgag tatgagctta gttccagcaa tttctaaagc atatgcatta ggaaataagt
    59881 caaaagctag aaaagatact aagagtgcag ttaaggtaac tttacttata gtattgcctt
    59941 gtgcgtttgg tatggcttct ttagcaatac caataatggg tcttttattt ccacatgaac
    60001 catcttctgt aggaactatt ttgtttactc ttactccatg tgtattattt ttaggattaa
    60061 tacagacatt gactggtata attcagggaa tgggaaaacc aatagtacct gtaattgctt
    60121 tatgtgttgg tatgctatgt aaaattgtaa taagttatac tttaacaggt ataccagata
    60181 ttaatgtact gggttcagca tttggtacag ttacagcata ctttgtggca gccatgatta
    60241 acttactata tgttaaaaaa cacatgaatg taaacttttc taaaaaagaa tttataataa
    60301 agccatttat aacagttatg acaatgttta taatggttaa gttgagttat ggtgctttag
    60361 ttggattctt aggaaacagc atatctacaa taattgcaat atgtgttggt ggaattgtat
    60421 atgtagtagt aatacttgga ataggtggaa ttaaaaaaga agagattcta actatgccaa
    60481 aaggtgataa attatataaa ttgttaaaaa aagttaaact tataagataa tataggaata
    60541 tatatgcaaa taaaggaaat actatacaaa tagtaaatct ccttatttgt ataataatat
    60601 aaaaataaag tgaaatttgc taataggagt gatgttatgg gtaagataag tattgtaggt
    60661 cttggaccag gagactattc tcttataagc caaggtgtgt tagaatcttt aataaatagc
    60721 cctaaagttt tttttagaac agagaaacat ccaataattg ataaacttaa agaaactata
    60781 caatacactt ctttagacta cttttatgaa aaagaggaaa attttgataa tgtttatttg
    60841 aaaatatctg aatttatcat agaagaatca gcaaagggtg acctagtgta tgctgttcct
    60901 ggtcatccaa gagttgcaga gaagactgta agtataatag agagattagc caatgaaaag
    60961 cacatagcag tagaaatatt gccttctatg agctttgtag acgctatgtt taactatttg
    61021 gctatagacc catctgaggg atttaaactg gtagatgctt ttgaaataga aaattcatat
    61081 atagacttgg atacaagtat gataataact caggtatatg ataaatttat agcatctaat
    61141 gtaaagttaa aacttatgga acattatgac tataatcaag aagtatgtat agtaaatgga
    61201 gctggtgtca aagatttaga aagtaaaaag tttataaagc tttgtgaatt agacagaaat
    61261 gaaaactttt ttgactattt aactagctta tatataccca aaagttctaa aaagatgtat
    61321 aatacagtac atgacttaga aataatagtt aatacactta gaagtccatc tggatgtgaa
    61381 tgggataaaa aacaaacaca tcaatcatta aaaaattctg ttatagagga agcatatgaa
    61441 ctttgtaatg caattgataa taatgatata gatgaaatgg tagaagagtt aggtgatgtt
    61501 cttttacagg ttatattcca ttgtcagata ggaaatgagg agggctactt tgatttaaaa
    61561 gaagtagtaa atggcatatg taaaaaatta attcatagac atcctcatat atttagtggt
    61621 gcaaaattag atatgtctaa gtttgagaaa acttgggaag aattaaagaa agaagagaaa
    61681 ggcgaaagta ctataacaga tggccttaga aggataccaa aacatttacc agctcttatg
    61741 aaggctagta aagttcaaca taaagcagca cttgtcggct ttgattggga caatgtagaa
    61801 gatgtattta aaaaaattga agaagaatat caggaattac ttgacgaaca cagggtcggg
    61861 aatataaaat acataaagga agagctaggc gatttattat tttcgatagt aaatctagct
    61921 agatttttag acatagactc aggagaagcc ttgaactgta ctacagaaaa attcataaat
    61981 agatttgact ttatagaaaa aagtgcaatg aacttgaata aaaaattaga agacatgaca
    62041 cttgaagaga tggatgagtt ttggaatcag gctaaaaaac aataaaattg tggaaggaaa
    62101 tttgtcaaaa atctagaact tttatcacaa agatagaagt ctatattata aacattttta
    62161 ggaggtaaat atcgtgaata aagctgaatt agtatcaaag atggcagaaa aaagtggatt
    62221 aacaaagaag gaagcagaag ctgcgttaaa cgcatttatg agttctgttc aagatgcact
    62281 agtaaataat gaaaaagttc aattagttgg atttggaaca tttgagacaa gagaaagagc
    62341 tgctagacaa ggaagaaatc caagagatcc agagcaagtt atagatatac cagcttctaa
    62401 agcaccagtt ttcaaagctg gaaaaggatt aaaggatata ataaatggat aattagaaat
    62461 cttgtgaaaa agtgtggata aatttgccac actttttcta tagaaccaag gaaggtgata
    62521 attatgagat tagataaatt tttaaaagta tctaggatta taaaaagaag aactgttgct
    62581 aaagatgcat gtgataaagg gattgtcact ataaatggaa aagttgctaa atcttcttca
    62641 gaggtgaata ttggagatac attagaaata caatttggag agaagaagat gaagtttaag
    62701 ataaatgaag taaaagagca tgtattaaaa aatgatgcaa aagaaatgta caaaatttta
    62761 gaataaaatt aatagtcctc tagtatatta atagtagtat tattgaaata tttactgggg
    62821 ggatattatg gaacagaaca taactttgaa agatagatca aagctggtta tttcgggagt
    62881 cgagcacata tactctttta atgacaaaag agtagagctc aaaacttctg taggcgagat
    62941 ggtaattgaa ggcgaaaacc tagatatgag caagctaagt atagacgaaa atataattag
    63001 catagatgga actataaatt ctatggtata tgcaaagcct aaaaagccac aagagagttt
    63061 cttgaaaaag gtatttagat agatgatacc ttttactcaa gatgtaagca ttttttatgc
    63121 tactatttat ggtggaatac tcataggggt gttgtttgat ttttatagag ggctaagagg
    63181 gaattttaaa ttcatcaatt attttgctat aatctttgat gtattgtttt ggtttctagc
    63241 tacggttata atattcgtaa caataaacct tacagaattt tttgatttaa gatattatca
    63301 ttttgtggct ttgtttattg gttttatttt atactataac accataagta aaattgtttt
    63361 atcaattatc aataaaataa ttcgttttgt gagaaattct tttaaaaaag ttacacatta
    63421 catagtcagt tttttaaata atttgtatta cgttataatc tattcactac acctactatt
    63481 tgatattata ttttatatac caaacatatt tatagcaaca agaaaaagta taaaaagaaa
    63541 atcaaataaa aaattaaaga acaagaaaaa atcaaaacct aagaagaaaa aaaataaaac
    63601 taaaaaaagg gtgtaggaaa aatgaactta agaaaaaaat tttcaggaca gattattgtt
    63661 atcagtttat ttttaggaat atcaattttt agtatgatga caggatttgt atttgagtat
    63721 acaaaagcta aggaatataa aaaagaaata gcaagtctaa ataaacaatt aaaaaagact
    63781 gaaatacaaa taaacagctt aaagaaagat gaaaaatcat atgaaggaga cttagaggat
    63841 atagcaagaa aaagattgaa tatggtaaaa ccaaatgaaa cagtttatgt agacataaat
    63901 cgttgattaa aacttgctaa taagtttaca gatgtattga ttttaaaatt taagatttaa
    63961 taaaaaagtc attcagttaa ggatggcttt ttgtttttat tgaggaggga atttcataat
    64021 gaaagtagga gctatagata ttgggacaaa ctcaatgaga ttattgatag cagattatag
    64081 agatgggaat tttataaaca gaaaaaaatt tgttaataca actagaattg gttatggtgt
    64141 ggatagtaaa ggatatataa aagaagatgc tatcaaaaga aatataaaag cattaaaaga
    64201 attttctgat aagtgtaatg atgaaaagtg tgaaaaaatt tattgtatgg ggacatctgc
    64261 tcttagagac agtaaaaatg gagattactt tgttaaatta gctaaagaag aaactggaat
    64321 agatgttgat atagttacgg gaatagaaga atcaaatttg ggctttaagg gtgttttaga
    64381 aggaatacaa ggtgatgata ctattattgt tatagatatt ggaggaggtt caacagaatt
    64441 tattgtaggt gattcagaag gaattaaatt taataaaagt gagaatgtag gtgctcttag
    64501 gatgacagag aggtttttga agcacgatat tattgaagat gaagagtttg aagctatgag
    64561 ttcatttata tatgatgaga ttgacaaaac gttaaatcat ataaaagaca gaggattaaa
    64621 aactcttata ggtataggag gtacgattac atcattatca gcaatgaatc aagaattaga
    64681 gatttactct atggaaaaaa tacataatag taaaatacac aaaaaagaaa tagaagaaat
    64741 tctacaaaaa ttaataaaga tgacattaag tgataaaaag aacttaaaag ggctacaaga
    64801 aaaacgtgcg gatattataa ctgctggtgt aaaaatattg aatataataa tggaaaaatt
    64861 agaaatagaa gaaataaccg taagtgaata cgataatttg gaaggcttaa tatgtcaaaa
    64921 gtcaaaaaaa atgtattaat attttttgat ttttaaaacc gattatgaca aaaaaaatta
    64981 ctcctctttg ttacaattct taatataaac aaaagaggag gtttttttat gcaaagaagt
    65041 gtagcagttg tgaagaataa gactgtaaaa ccaaatgtca taaaattaat aagcggatat
    65101 attgatttta ctacggcggc attcgctgtg atgggatttt tacttagtag gtctattata
    65161 gtagactctg tagctccttt aggaattgcc ttttttatat gtgcatcaaa gattgataag
    65221 tacaagatac ctgtattcat atcaacatta ttaggaatat tgttatcatc taatgatttt
    65281 ggaaatgtag caaaatatgc tgtgtgcctt acaatattta tggctatgaa taaaaaatta
    65341 aaattatcag attcaattgc taaggttgca tttataggtg caataatact acttccaatc
    65401 tccatgggac aagctttctt ttcaaatagg tatgtatatg gtcttcttat agcaggagta
    65461 gaagcaataa taatgtttat atctatatat gtgttttctt atgggatagg tttaatggcc
    65521 aatgtcaaca ataggatgtc tgtacggaca gaagaagcca tatcaataag tttactgcta
    65581 acctttagca taatgggaat aggagatata tctctgtttg gaatatcaat aaggaccatt
    65641 ttatcgaccg tattgatatt gctgacctca atagtaggtg gagctaccat gggagcatct
    65701 agtggtgtaa ttattggtgt agcatccatt ttaaataata tgacatcagc tgtttatatg
    65761 gggatatatt ctttttcagg attaataagt ggagcattta ataaaataaa taaatatttc
    65821 tgtatactag gatatattct aagttggaca ataatatacc tatatacttc tggtattact
    65881 tctaatatga tgcaattaag agatatacta ttaggttgtt tgatagtact agtattgcca
    65941 gagagattat ttaataagat tgaaaaatta ataaaaagta atgtggcttc aaatgaaatc
    66001 gtatacgatt atattatgag aagcaaaaac ctaactaata gcagattgaa cagtatttat
    66061 aaaacttatg atgaccttgc agatacattt gataagataa gagaaaaaga caaagtgcta
    66121 gaccaaagag acatagctaa tgtaatagat atgattcata atgatgaatg taaaagttgt
    66181 agtatgagaa gaatgtgctg ggagtcaaga tttaatcata catacactat gatatataac
    66241 attcttgaaa aaattgagga gaaaggggag ttaagtctaa acgatatacc taaaaatttt
    66301 agaaaggaat gtatgaaacc agagtcaata gtgaaaatat caaatcacta ttacaaaatg
    66361 tttgtattag attatgattg gagtgtgaag ttttcagaaa gtagaaagtt aatagcaaat
    66421 cagataagaa gtatttcaaa atccattaaa tccttatctc aagatttaga aggcgacata
    66481 atgctagata tagaaaagga aaaaaatata tatgaacagt tagaaagata tgatataaca
    66541 gttgataaag taagttactt aacaaaaagt aacagtgagt ttgaaatatc aatagaaaag
    66601 aaaacttgcc atgatggatg tatgtgtgaa gataaaattg taaatataat ttcagaccta
    66661 gtaggggaaa atatgtctgt tagaaaaata ggatgtcact gtttaggagg taaatgcaag
    66721 gcaacattcg ttaaatctca aaaatataag gctgttacag aagtttcagc aatgtcaagg
    66781 gatgggcata tcctttgtgg agacaattac acatacatgg agataaatga tggtaaatac
    66841 atgatggcta taagtgatgg tatgggaaag ggtaaaaaag catatgaaga atcttctgcc
    66901 actattgata tactggaaaa aatgatagat gcaaaaatta aagatgagat agtcattgat
    66961 actataaaca atatgttgtt gttaaaatct tcagaagaga tgttttcaac tctggatttg
    67021 ggaattttag atttaaaacg aggttgttta gaaactataa agatgggagc gtgttctact
    67081 tatataaaaa gagaggatgg agaagttgac ttaatatcat catcatcatt acctgtgggt
    67141 atattatcag atgtaaaaat tgatagaaaa aatgtaaaag ttaaggaagg agactatgtt
    67201 ataatggttt ctgatggaat tgtagatgca ggaagaaata acaatttagg agacaattgg
    67261 ttaatatact tcttaaagaa tatagagact acaaatccaa aggaaatttc aaatttaata
    67321 ttggatagag cattagagtt acaagcgtta caaatcgaag atgacatgac tgttttagtt
    67381 acgaaaatat gtacaaaata aggtttacaa gattatgtgt ataagatgtg gataacttgt
    67441 gtataatatg ttaatagact tttgaaaaaa gtatagttat taacaaaaat aacatataaa
    67501 tcaacaaaat ttgttgataa gtatggcaga aatgttaata aaatgtaaaa aaagaaaaaa
    67561 caaaagctat tatcaaaaga gattcatgtt gaaataacta aatttctaag taaagaaaac
    67621 ctgtgaatat gttgattatt atgtggataa ctattaattc gatatttatt tatatagtat
    67681 gaataattga ataatatatc taaaaaaagc catcctatta ttaagtaaac ttattgaaag
    67741 gatggctttt tatgaataga aaattgtgca aagcaataat acctttattt atttctattt
    67801 tttgcatgtt aataataagt ataaaagctg accaaggata tcaaaagaat aatgacagag
    67861 caattactgt catgaataat aatgatactg aagatgatgc tgaaaaaaaa caagaaatag
    67921 actatgaaaa aacatgttgg aatttgcaat ctttgtttaa aagtgatgac caatggaaaa
    67981 aagaacttaa gagttttgat aaagatacta aagagttgaa aaattacata ggtaaagtaa
    68041 caaaatcgcc aacacatttg tcttttgcct tgaacattaa agaaaaactt gatataagac
    68101 taaataaact ttctgcctat gtaaaattaa aacaagatac taataaaaat tcgtataagt
    68161 acttagatat gaatgatagt atgagtaaat cctatgggaa ttatatgggg atttgttcag
    68221 atttagagtt agaaatacta aaattatcaa acaaagatta caagaaaatt atttcaaata
    68281 aaaatataaa taggaaatat ggtgcatatt taagagatat aagaaggaat aaagtacatt
    68341 atttggatga taaatcagaa gatattctaa gcaaagtatc ttcaataagt agtcttccaa
    68401 gtcaagtgta tgaattattt agaaatatgg atagaaaaac taatttaaca ccagctcaat
    68461 atgcgagtga attagagtca tcagatagag aaaatagaaa aaaagcttat caagatgaac
    68521 ttataactta caatgataat ataaatacaa ttgcaggttt aattactggt caagttaaaa
    68581 agaatatttt ttattctcag gaaagaggtt atgagtcttc tttagaaatg tacctggaag
    68641 ctgataatgt agatgaaaaa gtatacaata atttgataag gactgtaaat agtaatatgg
    68701 acagtctaca caaatatata gatttaagaa aaaaagtatt aaaattagat aaggttcatt
    68761 catatgatat gtttgtgcct atggttaagg ctgttgataa taatattaat tatgaaaagg
    68821 cacaaagtat agtatattca gcgttgtcac ctttaggaaa agaatacaat gatgtagtat
    68881 ataaagcttt caatgaaaaa tggatagatg tttattcaca tgaaaataaa gtaagtggtg
    68941 gatactgctt atctgtttat gaaaatcatc catatatact tttaaattat aataattcat
    69001 taggttcagt ttcgacttta tcacatgagc ttggacatgc tgtatatgaa tacttaagtt
    69061 ctaagaatca gaattatttt aattcaaatc cgtctatatt tactcacgaa gttgcatcta
    69121 caacgaatga agcattactt tacgagatgc ttataaaaga agctaaaggc aatgatgaaa
    69181 aagcttatta tataacacag tatttagact tgataaaaga tactctttat acacaaacta
    69241 tgtatgctga atttgaaaaa actatacacg agttagtaga aaaaggaaaa agtgtaaacg
    69301 cattagtatt aaatgatgtt tggggacaac ttcttaaaaa atattatgga caaagctatg
    69361 aattagacca attatctaag gtcggatggg ctagaatccc acatttttat aatagtttct
    69421 atgtctataa atatgctaca ggttgtagtg caggagtaag ttttgcccaa gacatcctaa
    69481 agaatggttc agataactat atgagctttc ttaaaaaggg aagttcagat tatccaataa
    69541 acttgttaaa atcaagtggc ataaatttaa ctaatacaaa acccatagaa aatacaatca
    69601 aaaaatttga tagtttagta gcagaacttg aaaagctatt ataaacatta ttgtaatcca
    69661 catggtaaat atatcgaatt aatgataaaa tatactaaaa gtttaaagtc ctatcaagat
    69721 aggacttttt atttattaat tagtgggaga tgattctatg caagttaaag ttaaaaaggc
    69781 tgtaatacca gcagcaggtt taggaactag atttttgcca gctacaaagg cacaaccaaa
    69841 agagatgtta ccaatagttg ataagccaac tctacaatac ataatagaag aagctgtggc
    69901 ctcaggaata gaggaaatac taataataac aggtagaaat aaaaaatcta ttgaggacca
    69961 ctttgataaa tctgtagaat tggaacttga tttagagaaa aaaggtaaga aagaattgtt
    70021 ggaggtagta caaaacatat ctaacatgat taacatacat tatataagac aaaaagagcc
    70081 aaaagggttg ggagatgcaa tttattgtgc gaggcatttt ataggtgatg agccgtttgc
    70141 agtaatgtta ggggatgata ttgtagataa tgatgtacct tgtctaaaac aactaacaga
    70201 tgcatatgag gaatatagaa ctacaatatt gggtgttcaa aaggtaaatc aagaagatac
    70261 taataaatat gggataatag aagcaaaaaa tatagaaggt agagtttaca aggtaaaaga
    70321 catggtagaa aagccagagt caggaaaagc tccttcaaat attgctattt taggtagata
    70381 tataataact cctgaaatct ttgatattct taaggattta ccaccaggta aaggtggaga
    70441 ggtacaactt acagatgctt taaaaatatt atctaagaaa gaagctatgt atgcatacaa
    70501 ttttgaaggc aagagatatg atgttgggga caagctagga tttttagaag ctactgttga
    70561 ctttgctcta aagaaagaag accttaagga agattttata aaatatttga aacatgtatg
    70621 tagtgaattt gataaaaata acaatgtgtt atacaataat acagatgaaa aaatagattt
    70681 aattgaagtc aatgaagcta gagaacttga aattcaaaaa taattaatga aaggtgatgt
    70741 atggtggcaa aatcaagtca gaaaagaatt aatagaataa tagctgttgg gattgtggga
    70801 atcctcgtaa taacgagtat aacagctgtt ttgagtatga ttgcaactat gtaataagat
    70861 aaatgacagc agttgatata cataaatata aaaaccatat ataacttgat gtagtcaaaa
    70921 acttacaata ttttagttat atatggtttt tagaatttat aaatgtaaaa aaaaattttt
    70981 ataatagttg catattttaa aggaaaatat tattataaga tataaatata gtgataaatt
    71041 tataaaaacg tgctaagatt ggacttgaaa tacagtaata tagtaggtaa taatgtttta
    71101 aattttattt attgaccata atatataaat aatgatatta ttagacttaa ctgtttaaat
    71161 aaaacttttc tttttcatgc cttcaatttc caaaataagt atgtatataa atgaatatat
    71221 agatgaggag gatttttttg attttagatg ataaagtatt agaaggatta ggtagtaaga
    71281 ccttagttga gctacgagag atagctaaag aattaaaaat aaaatcaatt actacatata
    71341 agaaaaatga gttaattgag attataaatt ccaaaagtaa aaatgaggaa aaagtaaacg
    71401 aagagactaa agaaaaaaat gaagatatta aagaagacat aaagaataga aaagaaaata
    71461 tagagcgtga aagtatagaa aaagaagttg aatataagag ccctaccaaa tcatacaaca
    71521 agaaagaaat agatacccaa aatatttccc aaaaccaaga acatagaaat caaagaaatg
    71581 actataataa gacaacgagt gtaaatgata gtaataagtc atcaaatata tctaatagaa
    71641 tggtcagaaa taataataaa aactattata tgcctaaaca agttgatgaa tctaagatag
    71701 tagatgaatt taacacatca aaagaggatg aagtagtagg tgtacttgaa attctgccag
    71761 atggatttgg ttttttaaga ggttcaaatt atttgtctac tgaaggagat gtttacgttt
    71821 caccatctca aataagaaga tttaatatga aaacaggaga caagattaag ggaataacta
    71881 gacatccaaa aagtggagag aaatttagag cacttttata tgttcaaaaa ataaatgatg
    71941 aaaaccctga cacagctata caaagaaatg cgtttgagac attaacacca atatttccag
    72001 aagaacgact tacactggaa actaatagaa atgaaatagc tacaagaatt atagatttaa
    72061 tttcacctat aggaaaagga caaagaggat tgatagtagc acctccaaaa gctgggaaaa
    72121 cagttctttt aaaaagcgtt gcaaatagca tagctaaaaa tcatccaaat gttgaactta
    72181 tagtactcct tatagatgaa agaccagagg aagttactga tatgaaagaa tctattgaag
    72241 gagacgttat atattctact tttgaccaag tatcaagtca tcatgtcaag gttgcagaga
    72301 tggtgttaaa tagagctcaa agattagttg aacatggtaa agatgtagta attttactag
    72361 atagtataac tagattggca agggcatata atcttacaat atctcctaca ggtagaactt
    72421 tatctggagg tattgaccct ggtgcacttc atggacctaa aaagttcttt ggtgcagcaa
    72481 ggaatattag acagggtggt tctttgacaa tattaggaac agcattggtt gaaactggtt
    72541 ctaggatgga tgatgtaata tttgaggaat ttaaaggtac aggaaatatg gagctacatt
    72601 tagatagaaa attagcagaa aaaagaatat tccctgcaat agatatttac aagtctggta
    72661 caagaagaga tgatttattg cttgatgatg aagaaaagac tgctctttgg agattaagaa
    72721 gagaaatgag taataattca gtaatggaaa ttacagataa agtcattgaa cttataaaga
    72781 gaactaagga caataaagag tttgtaaaat caataaagaa tttgtaaaat caataataca
    72841 aatgcaaata tggattatat aaactaatag aaaaatcact tgaatggcat aataagttgt
    72901 gctataataa tgtagttgat aatgtaaaaa gaaagttaat ataattaatt tttttaaata
    72961 aagagaagag gtgactataa tgcaaaagga aatacaacca aaatacaatc cagttgaagt
    73021 gcgttgtgct tgtgggaaca catttgttgc tggttcaact aaggacgaaa taaaagttga
    73081 aatatgttca gagtgccatc cattctatac aggaaaacaa aagaacatag aaaaaggtgg
    73141 aagaatcgac aaattcaaga aaagattcaa aatggactaa tttttataaa agtggagttg
    73201 gaggaagcca actcctattt tattacaaaa aaacattcat attctacttt aaattgtctt
    73261 tttgtattat aataataaat atgtaaaatt gagtattcta aatacaataa aatgaggtga
    73321 gtggatggca aaacaagctg taggtgggca agctgttatt gaaggtgtaa tgatgcagtc
    73381 aaaagacaaa agagcggtag ctgttagaaa aagtgacgga gaaatagcac taaaagaaga
    73441 tagaataaaa agttgggtaa gagataagaa tatagataag ataccttttg ttagaggttc
    73501 ttttgttatg atagatacaa tgattcaagg cataaaaagc ttaaactttt cttcagagtt
    73561 ttttatggaa gaagctgaag aggataaatt tgatttattt ataaagaaaa tttttaaaga
    73621 taaggcaaat gatataatta taatattttc attggtcata gcaatgttac tttctgctgg
    73681 attattcatt tttataccta cattggtagg aggagctttt tctaaagtaa tgcctaatga
    73741 ttttatgctt aatttaatag aaggaatcat aaggatagct atattatttg catatatagt
    73801 attgatttca cgaagtaagg atatagaaag agtctttcaa tatcatggag cagaacataa
    73861 atctatatat tgctatgaaa atgatttaga acttacagta gagaatgcta gaaaatttaa
    73921 aagattacat cctagatgtg gtacaaattt cctatttata gttatggctg tatcaataat
    73981 attgtttgca ttttttggtt ggccaaatcc aattcttaga atatttatga gaattatatg
    74041 tgtgcctata gtagcaggtt tatcttatga ggtaattaga gttcttggga aatatgataa
    74101 tggatttact aaaattattg catatccagg aatgatgttg caatatttta caacaaaaga
    74161 gcctgatgat gagcaattag aagttgcttt ggaagcattg aaagcagtag tagattagag
    74221 aaaaggatat ttgttatgac gataaaagat ataattatta aatattcaga taaactaaaa
    74281 gatataagtg atactccaag attagataca gagttattgt tacaaaaaac attgggtgtt
    74341 gatagattat atattcactt aaatctgaat aaagagctaa ctgaagaaca aaaaacaaaa
    74401 tttatgggtt ttgcagaaga aagattaaat ggaagaccaa tagcatatat agttgaaaat
    74461 agggagttta tgggattaga tttttttgtt aaggaaggcg tattgattcc aagaccagat
    74521 acagaaactt tagtagaaga aataattgaa atatgtagag aaaaaaaaga tgtaagtata
    74581 ttagatatag gaactggttc tggagctatt acaataagtt tagcaaagta cattgaaaat
    74641 tctaaaatca tgtcttttga tatatcagag acagcattag aaatagctaa aaaaaatgct
    74701 attataaatg aagttggtga aaaaataaag tatattaatt ctgatttatt tacagcaata
    74761 agtgatagta acataaaatt cgatatcata gtttcaaatc caccatatat taaaaaacaa
    74821 gatatagaaa ctctgcacaa acaagttaaa gattatgaac catataatgc tcttgaaggt
    74881 ggagaagatg gattagactt ttatagaaga ataacagaac aaggtaagaa atatttaaat
    74941 aagtgtggaa tattagcata tgaagttggt cataatcaag ctgaagatgt aataaatatt
    75001 atgaaaagta atggatataa aaaaatatac acaaagaagg atattcaagg cattgataga
    75061 gttgttatag gttacaatat atgatataat caacaattga tatgttacat ttaatcgagg
    75121 tgaaagtatg ttaaaaaaat tagaggtatt ggaagataca tataaagact taagtgaaaa
    75181 aataggtgat ccggatgtaa taaatgatca aaaagtttgg cagaaatata taaaagaaca
    75241 tgctgacttg gaacctattg ttatgaaata cagagagtat aaaagcgttt tagatagtat
    75301 aaaagaatca aaagaaattt tacaagaaga gtcagatgaa gaattaagag aattagctaa
    75361 aatggagtta gctgagatgg aagaaaaagt agcacctctg gaggaagaaa taaaaatact
    75421 attattgcct aaagacccta atgatgataa gaacgttata gttgaaatta gaggtggagc
    75481 tggaggagat gaagcagctc tatttgctgg tgatttattt agaatgtact caaggtatgc
    75541 tgaaagaaga agatggaaaa tagaattatt gagtgcaagt gatactggag ttggtggata
    75601 taaagaagta tcttttatga taaaaggtaa aggtgcttat tcaagattaa agtatgaatc
    75661 tggagttcat agagttcaaa gaataccatc aactgaatct ggtggaagaa tacacacatc
    75721 aacttctact gttgcagtat taccagaagt tgaagatgta gaggttgaaa taaatccaaa
    75781 tgatttaaga atagatgttt tccgttcttc aggtaatgga ggacaaagtg tcaatactac
    75841 tgactctgct gttagggtaa cacatatacc tacaggtgaa gtagtatctt gtcaagatgg
    75901 aaaatcacaa ttaaaaaata aagagcaagc tttaaaaata ttaaaagcta gactttacga
    75961 taaagcattg gcagaacaac acaaagatat agcagcagaa agaaaaagcc aagtcggaac
    76021 aggagacagg tcagaaagaa taagaacata taatttccct caaggtagaa taagtgacca
    76081 tagaataaat ttaactttat ataagttaga tgcattctta gatggagata tagatgaaat
    76141 gatagatgct ttaattactg ttgaccaaac agaaaaaatg actgcaatat aagtaatgtt
    76201 ttaaagaagc tgtttcttcc tagaaattat tttctatttt gaaacagcta ttttgcattt
    76261 taggtcatgt tatcatattc tattgtatat aattgttata tacaagtata ggagggttat
    76321 atgatactaa aagtaacaat aattgggctt ttggcaggtg ttatagggac aggattagga
    76381 ggagtaatat cagccatttt taaaagagag gtcgataaat atctaagttt ttttatggga
    76441 ttatctggtg gaataatgtt ggctgtagtg gtgtttgatt taatgaaaga atccatggac
    76501 aaaatgggga taatcaatac agttatattt acgtttgttg gagctctcat aactatgtac
    76561 ataaaaacaa aattagatgt gtctggaaat atggcatctg gatatcttat attcataagt
    76621 atattactac ataatttacc agaaggacta gccattggtt cttcttttat gtcaactgaa
    76681 agtttaggta ttacacttgc tatagttata ggtctacata atataccaga agggttagct
    76741 atggcattag gcttagtttg caataaaatg aaactaagta aagttatttt gtttactgta
    76801 atagctggat tacctatggg tctaggaagt tttttaggtg tttattttgg aggagtattt
    76861 acttctctta taggagtatt tcttgctaca gcaggaggta ctatgatgta tgttgtattg
    76921 gaagaaattt ttccacattc aaaaagtgtg tattgtataa ttggtttctt gttaggtaca
    76981 atgattgtaa attatatata aaattaaaat gaaagcaggc atacaaaaga tgaaaactat
    77041 tataagtaat attgatataa ataatattga ttatgaggaa ataaaaatac aagcaaaact
    77101 tcttagagaa ggtaaaacag ttatttttcc aactgagaca gtatatgggt tgggtgcaaa
    77161 tgcattagat gaaaatgcag taaagaagat ttatgaagct aaaggaagac ctagtgacaa
    77221 tccattgata gtccatatat atgaaaaaga agaagtatat gacttagcca aagatataag
    77281 tgataaagct aaacttgtta tagaaaagct ttggccagga cctataacaa ttatattaaa
    77341 taaaaaagat ataattccat acaaaactag tggagggctt gatacagttg caataaggat
    77401 gccttctaat gttattgcca gggcaataat aaaagaagct ggtataccta ttgcagctcc
    77461 ttctgcaaat atctcaggtc gcccatctcc aacaaaagca aaacatgtat atgaagagat
    77521 gaatggaaga gtggatggaa tagttttagg aggagacagt aattttggat tggagtcaac
    77581 tgtattggat ttaacagaag agactcctat gatactgaga ccaggaagta taactaaaga
    77641 agttttagag gaacttcttg gagaagtaaa gcttgaccca tcattaagta aaaaagaaga
    77701 taatcaaaaa gctaaagctc ctggaatgaa atataaacat tattctccaa atgcagatgt
    77761 atatataata tctggaaaaa gagaaaatgt agcaacaaag attaatgata tgataaaatc
    77821 taatagagac aaaggtctaa agacaggtgt aatgtgtatt agtagaaacc gagagtttta
    77881 tgatggagaa gtaatcgatt taggaaactc tcttgaagaa gttgcaagta atctgtttga
    77941 tgctcttata gaaatggaca aaaagggtgt tgatgtcata tattcagaag agttccctaa
    78001 gactggagtt ggacaagcaa ttatgaatag actactgaag tcagcaggat acaaagtgat
    78061 aaaggcttaa gagggagttg taaaatatga atatacttat tgtgtgtaca ggtaatactt
    78121 gtagaagtcc tatggctgag gctatactaa ggaaagcaat taaagaatct ggaagaagta
    78181 ttgaagaata ttctatatca tcagcaggta tatctacagc aaatggaatg ggtgcttctg
    78241 aaaattctat agaagtacta aaagaaatcg gtatagactt atcaaatcat agaagtaaag
    78301 taattactaa aaaattaatt gatgaatcag atataatact aacaatgact aaatctcata
    78361 aagaaatttt agtacaagca gttccaaaat gcaaagaaaa agtgtatact tttaaagggt
    78421 ttgcaaataa aaatgaggaa gatatatctg acccatttgg tggaaatttg gatatttata
    78481 gaagcactat gagagaaata atgtattctg tcaacgaaat agtaaaaaaa atatgaaacg
    78541 gaggataaac aaatgaagat aggattaggc tgtgaccatg gaggatataa tttaaaaaaa
    78601 gaaataataa gctatttaga aagtaaaggc atagaatgtg tagattatgg aactaataat
    78661 gctacagatt ctgttgatta tcctgtttat ggagaaatag ttgcaaattc agttataaat
    78721 aaagaagtag attatggaat attatgttgt ggtacaggga taggaatatc tttagctgct
    78781 aataaggttc ctgggataag atgtgcagtt gtatcagatg tattttctgc aaaaatgtca
    78841 aaagcacata atgatgcaaa tatgttatca ttaggcgaaa gagttttagg aaaaggtcta
    78901 gcacttgaga tagttgaagc atggattaat acggattttg aaggtgatag acatgctaga
    78961 agagtaaaca tgattaaatc aatagaagaa aaacataata aataataaaa attacagttt
    79021 tatcaggagg aattatcaaa atgagcaaag tggtagagac aaaccatcca ttaatacaac
    79081 ataaattaac tttaatgaga gataaaaata ctggttctaa agactttaga gagcttttaa
    79141 ctgaaattgc aatgttaatg gggtatgaaa taacaaaaga tataccatta aaagatgtag
    79201 aaatagaaac tcctattcaa aaaacatcat ctaaagtagt tgcaggtaaa aaattagcaa
    79261 taattccaat tttaagagca ggtcttggaa tggtagatgg attagtgagc ttaatgccag
    79321 cagcaaaagt tggacatgta ggactatata gagacccaga aacattaaaa ccagttgaat
    79381 attattgtaa gcttcctcaa gacataggag aaagagatat aatagtagtt gaccctatgc
    79441 ttgcaacagg gggttctgct gtagcagcta tagatttact taagtctaaa ggagctaaaa
    79501 gtataaaatt agctaattta gtagctgcac cagaaggtat agcagaagtg caaaaatatc
    79561 atgatgatgt tgatatatat gttgcatcag ttgacgaaag attaaatgaa catggatata
    79621 taattcctgg tcttggtgat gctggagata gattgtttgg aactaaataa aaataaataa
    79681 ctataaatat ttattaggga ctttcttata tagtgtatat aattttatgt aagaaggttc
    79741 ttttttatat attttttctc aaaataggaa ttattgaatt gataaatttc tcgaattgag
    79801 aataaaaagt ttttaccaat taaaaaagat tgcttatttt acaaggtttt atagaatagt
    79861 agtctatttt aatgtggcat gttagttgct tacgattaag attataggta ttaagtgtat
    79921 tagttaaatt gagaattgaa tattaataat attattggga gtggtaatac atgaagaatt
    79981 gtatagtagt aagaggggct ggagatttag caacagcagt tattcataaa ttacacaaca
    80041 gtggttttaa agtagttgcg ttagaaatag aagagccatt agctataaga aggcaaattt
    80101 ctttttgtga ggctgtttat gaaaaaaaag taactgttga aggtgtagaa tgtatatttt
    80161 gcaatactga aaaagaaata gaagaagttt tatctcaaca taaagtagcc ttgattatag
    80221 acccaaaagg agaaaaatta tctaaattaa atccaatcgt tttggttgat ggaatactcg
    80281 ctaagaaaaa cttaggtaca actaaagata tggcaccact tacaatagct ttaggtcctg
    80341 gattttgtgc aggagaagat gtagatgttg ttatagagac aatgagaggt cataatctag
    80401 gaagaataat aactaatggt agagcagaaa aaaatacagg agtaccagga gcaataaaag
    80461 gtttttctaa agagagagtt atgcattcac agtatgatgg cataatggaa aatgtatgta
    80521 agataggtga tatagttgaa aagggagacc tactttgcta tattaataat tatgaaaaaa
    80581 aacatgaagt tagagcaaca atatctggag tccttagagg tttattaaag gatggagcaa
    80641 aggtaaacaa aaatttaaaa atactagaca tagaccctag aaaagaagaa gttaagaatg
    80701 cttttacaat atcagataaa gctagatgta tagctggagg ggttttagaa gccatactaa
    80761 acaatgggat ttatccccaa aattaattta tattagataa agctattaat attttattaa
    80821 gatgatataa taaatttaat agattaaaga gagcatatga cgggtattta aaatttaaat
    80881 ggtaaaaatg ctcttttttt attggacatt caattaacat gtgtatataa tataaaaata
    80941 agtatttatt taggttgaaa tctaataaat atataatacc agtacataag caaagaggag
    81001 aaaagtaaat tatgagacca tcatgggatg aatacttcat ggaaattgca gaagtagtga
    81061 aaaagcgttc aacttgtatt agaagacaag taggagctgt aattgtaaga gacaaacaaa
    81121 tattaacaac tggatataat ggttctccga gaaatcttga acactgtgaa aatattggat
    81181 gtaagaggca ggaattaaat attccctcag gagaaaggca tgaattatgc agagcattac
    81241 atgctgaaca aaatgcgata atacaagctg ctcataatgg tattagtgta gatggggcaa
    81301 ctttgtatgt tactacaaga ccttgtgttt tgtgtgcaaa aatgtgcata aatgcaggta
    81361 tattgaaaat tgtttatgaa ggtgattatc cagatgatat gtctacagaa ttattaaaag
    81421 aagcaggaat agaactcata aaattttagt ggataaaatt tatatgacaa taaatgtcaa
    81481 attatgacac tgaaatacaa tggtatcaaa tgattaaaag aaagtatttg aaaaatcatc
    81541 agattagtag taagatatat tttataatta aataaattta tgagatagat taattacatg
    81601 ttatttattt tataataatg agggatacta tttatgagta aaagaaatac acatacagaa
    81661 attgcaaagt tgtttagttt aataagccaa ataggattga tgattgtaat atcaatatta
    81721 ggatgtactt tcttaggaaa atttttagat agtaaattga atactactcc agttctgaca
    81781 ataatatttt tattgttggg tgttggaggt gcttttagtg gtgtttataa aactctaata
    81841 gtatatacac gaaggaagtg atatattgga tataaaatta cttaaccagg taaggtcagt
    81901 aacaaaaggt atagtaatat ttgatgtagt tttaattgtg ctaatgttga taacatcaac
    81961 attaagtaaa ccagtattat taggacttat atttggctct ataatagcta tgttaaattt
    82021 tagattattg gcgatatcac tggaaaaatc agtgacattt cctgctggga aggcacaagc
    82081 ttatgcatca gcacaatatg ctgttagatt atttataatg gcagttgttc taattgcatc
    82141 agctacagta ccacatttaa atataatcgg aacagcattg ggattattga gcacaaagtt
    82201 tgtcatatta tcaaaaaact ttataaataa attaaagagg aaggaggcat aagtatgaat
    82261 caagcgcatt attatctcat aggaaacttt aagattagtg aaacaatact agtaagttgg
    82321 ggaataatgg cctttttagc gatagcatct tattttttga ctagaaactt aaaaaaagtt
    82381 ccaactagta aagttcaaat attcttagaa tttgcagtag gtggtcttgc taaaatggtt
    82441 acagatgtta tgggtaaaaa tacagtaaaa agaatgccat atatgatacc atacatagga
    82501 agcttgtttt tatttttcgc atgttcaaat ttaagcccat tacttggatt aaggtcacca
    82561 acaaccgact tagatacaac tgctgcatgg gcaatgatta cattttttat gatttatttt
    82621 gcaggagtta aatttaaggg gttatcatac tttaaagaat tggctcaacc acttgccata
    82681 atgttaccaa tcaatattat aggtgagtta gctagaccaa tatcattaag tttccgtcca
    82741 tttgggaata ttttaggtgg aacaataata atgggtctgt tttatcaact tttaggtttt
    82801 atttctagtt taataccagg attatcaata ccaattggag aaatattaat accagtccca
    82861 ttacacttgt actttgactt atttgcagga ttgttacaag catatatatt tataatgtta
    82921 acaatggtat ttatatcaag tgcaggagag ttagattaag aaatcaactt atattaagat
    82981 aaaaataaaa taatttaaaa aattaaagtt ttaaggagga aataattatg gaaacagcaa
    83041 tagtagcggc agcatcagca ataggagcag ggatagcagt tgcaacaggt ataggtgcag
    83101 gtataggtca aggtatagca gcagctaaag ctgcagaagc agtaggaaac cagccagaag
    83161 ctaaaggtga tataacatca actttattac taggagttgc tatagcagag tcttcagcaa
    83221 tatatggttt ggttatatca ataatacttc tattcgtaaa tccattcttt aaatacttag
    83281 gaatgtagat ttagtcctta aatattttga gataggttta taggtaaatc atctcaaact
    83341 tataatcatg agatgaactt tatcatctcg tgattataag tagttatgat ttatggaaag
    83401 gaggataatt atggaaaaag cactagtagg tataacgtgg gaatttgtgt tccaaattgt
    83461 taatactttt ataatatttt tacttctgag aaagctttta ttcaagccag tattaaatat
    83521 aattgaatca agagaaaatg atattaaaag tgatttggta gaaggcgaaa aagcaaaaaa
    83581 tgaaggttta gctctgaaaa aagaatatga gtcaaaaatc aattttgcca aagatgaagg
    83641 tcaagaaatc ataaaacaag caactataag agcagagcag aaatcagatg atatagtaaa
    83701 tactgcaaag aaagatgctc ttgatataaa agaaaaagca aacaaagata tagaacaaga
    83761 aagacaaaag gttataaatg aaatcaaaaa tgatatatct aacatagcac tacttgcagc
    83821 atctaaagtt attgaaaaag atttagataa atctaaacat gaagaattga tagaaaactt
    83881 tataaaagag gtaggggaag ctaaatgata aatgtaatag caaatagata tgccgaagcc
    83941 ctatttcaat taggagaaga agaaaattca actgatgtct tattcaaaga actagaaaaa
    84001 gtagtagata tgatgactaa agttagtaaa gatttctaca aagttttaaa atcaccatta
    84061 gtttcaaaat cagaaaagaa aaacttggta gaaattattt ttagtaaaga agtaagttct
    84121 aacataaaaa actttttaaa agttttagta gataaagata gaatatcata tttagaagat
    84181 atcgaattag cttataaaga attattaaat aagaaaaaca atgtaattga tggagtagca
    84241 ataagtgcta ttccaatgag tgaaacagat attaaagaac ttgaagtcaa actttcaaat
    84301 aaatacaaca aaaatgttac tatagaaaat gttgttgaca agactatact agggggagtt
    84361 ctagttagaa ttggaaatga acaaatagat ggcactgtga aaactcgtct tgataagatg
    84421 aaagaaaagc tatctgaagt aatatcttaa gaatggcggt gaacccatga acttaaaacc
    84481 tgaagaaata agttctataa ttaaacagca aataaaaaat tatgagaata aagttgagtt
    84541 gacagataca ggtagtgttt taacagttgg ggatggtata gcgagtgtat atggattaga
    84601 aaaagctatg tctggtgagt tgctagagtt cccaggtgaa atatatggta tggcacttaa
    84661 cttggaagaa gaagtagttg gagctgttat ccttggagat gacagtgaaa taaaagaagg
    84721 cgatatagtt aagagaactg gaagaatagt tgaagttcca gttggagaag ctttaatagg
    84781 tagagttgta aactcactag gtcagccaat agatggaaaa ggacctatag cgtacacaaa
    84841 aactagacca gttgaatctg aggcacctgg tataatagat agaaggtctg tttatgaacc
    84901 attacaaaca ggaatcaaat caatagattc aatgatacca attggtagag gtcaaagaga
    84961 gttaataata ggtgacagac aaactggtaa aacatctata gttattgaca ctatactaaa
    85021 tcaaaaagga aaagatgtta tctgtatata tgtagcaatt ggacaaaaac gttctactat
    85081 agctcaatta gttagctctt tagaaaaagg tggagctttg gattatacaa tagtagtttc
    85141 agcaacagca tctgaatcag caccacttca atatatagca ccatatgctg gagcagctat
    85201 gggtgaagaa tttatgtaca atgggaaaca tgtacttata gtgtatgatg atttaagtaa
    85261 acaagctgtt gcatatagag aaatgtcatt gttacttaga agaccaccag gacgtgaggc
    85321 atatcctgga gatgtattct atttacattc aagattactt gaaagagcag ctaagttatc
    85381 tgatgaattg ggtggaggtt caatgactgc cttgcctata atagaaactc aagctggtga
    85441 cgtttctgca tatataccaa caaatgttat atctataaca gatggtcaaa tatacttaca
    85501 accagagtta ttctattcag gtgtaagacc agcagttgac cctggtatat cagtatcaag
    85561 ggttggtggt tctgcgcaaa ttaaagcaat gaaaaaagtt gcaggaacat taaaacttgc
    85621 atattcacaa tatagagaac ttgcagcatt ctcacagttt ggttctgact tagatgaaga
    85681 tactaaaaag agacttgctc aaggtgaaag aatcgttgag atattaaaac aaggtgagca
    85741 tcaaccaata aaagttgaaa atcaagttat gataatatat gctgttataa ataatcattt
    85801 agaggatatt ccgatagata atatagctag atttgaatca gaattgtatg catttgtaga
    85861 taataattat ccggaaatat caagaaaaat attaggtgga gaagacttca ctcatgattt
    85921 aacagatgca ataaatgaat ttaaagaaaa gtttgttgtt gaagtataat cctttttaaa
    85981 aaaggaggta aattaattgg caggagctgg aatcaaagca atcaaaacac gtatgggaac
    86041 tgttgaaagt acaaagcaaa taactaaagc aatggaatta gttgcatctt ctaagcttag
    86101 aaaagcaaaa gaaaaggctg aagattcaag agaatatttt aatactttat acaatacagt
    86161 aaaagatatt gcccaaacaa cacgtggaat tagaaatgaa tttttaaaag aaagagaagt
    86221 aaaaaataaa tgctatgtag tagtagctgg agacagagga cttgcaggtg gatacaattc
    86281 taatgtatta aaggaatctg tctctcatat gaaaggtaaa aaggaaacag tgattactgt
    86341 tggaaagaaa gcacatgaat ttttttctaa aagaaactac aatatagcaa aagatataaa
    86401 tagtgttgaa gcttgtggat atgaagatgc gacagaaatt tcacaaacta ttattgacct
    86461 gtataaaaaa ggtgaagtag atgaagttta tattgcttat acaaaattta aatctgcttt
    86521 atcacaagaa gttgaaattt tgaaattgct tccattagtc tttgaaaaag atacagacga
    86581 acaaggaatg gcagtaaaag aagaaaaaca aaatagatca aaagtacaat atataccatc
    86641 agcagaagca gttttaagtt atattgtacc tcagtttata tcaggtacag tatatggtgg
    86701 aattttggaa tcttttgcat cagagcaagg tgctagaaga actgcaatgg aatcagccac
    86761 agacaatgcg aatgaaatgc tatctaattt agagttaagt tataacagag caagacagtc
    86821 agctgtaact caagaaataa cagagatagt tggtggagtt gaagctctaa aatagggagg
    86881 ttaggaaatg gcaaatgtag gtaaagtagt acagattgta ggagctgtac tagatgttaa
    86941 gtttgatagt gaacaaagcc tacctaactt attaaatgcg ttagtaataa agttaggaga
    87001 taaagaaata gttgcagaag ttgctcaaca tataggtgat gatactgtaa gatgtatagc
    87061 tatgagtgca acagacggac ttgtaagagg tatggaagtt gtagatacag gagggccaat
    87121 aagtgttcct gttggagatg aaactttagg tagaatattc aatgttcttg gaaaaccagt
    87181 tgatgggaaa ccagctccaa aatctgcacc taaattacct atacatagac cagcaccggc
    87241 gtatgatgaa ctagaaacta cagcagagat actagaaact ggtattaagg tagttgactt
    87301 actagctcca tatctaaaag gtggaaaaat aggtctattt ggaggagcag gagtaggaaa
    87361 gacagttcta atacaagagc ttataaacaa tattgctaag caacatggtg gtatttctgt
    87421 attttcagga gtaggagaaa gaacaagaga aggtaacgac ctttatggcg aaatgagtga
    87481 gtctggagtt ataaataaaa cagctctagt atttggtcaa atgaatgaac cacctggagc
    87541 gagaatgaga gttgctttaa ctggacttac aatggcagaa cattttagag atgagcaagg
    87601 acaagacgtt ttacttttcg ttgataatat attccgtttc acacaagctg gttcagaagt
    87661 ttcagcactt ctaggacgta tgccatcagc tgttggttat cagccaacat tagctactga
    87721 aatgggtgca cttcaagaga gaataacatc aactaagaaa ggttcaataa catctgttca
    87781 agcagtatat gtaccagcag atgacttaac tgacccagca ccagctacaa cattctctca
    87841 cttagatgca aaaacagttt tatcaagaca aatatcatca ctgggtatat atccagcagt
    87901 tgaccctctt gaatctacat caaggattct tgaccctagt atagtaggaa aagaacatta
    87961 tgaagtagct agaggtgtac aatcaatact tcaaagatat aaagaacttc aagatataat
    88021 tgctatactt ggtatggatg aattatctga tgaagataag ttaatagttg cacgtgctag
    88081 aaagatacaa agattcttat ctcaatcatt cacagttgct gagcaattta caggaaatcc
    88141 aggtcaatat gttcctgtta aagagactgt aagaggattt aaagaaattc ttgaagggaa
    88201 acatgatgac ttaccagagt cagcattctt atttgtagga acaatagaag acgctgttag
    88261 aaaagcgaag ggaagtatgt agtcatggcc agtgaatttt cattgaaagt tgtaactcca
    88321 agtaatactt tttatgatgg agatgttgaa atgatagtag ttagaactac aaaaggagac
    88381 aaaggggtgt tgaaaggtca tataccattt gtttcaggta tacctgtagg aactttaaag
    88441 ataaaaaaag agggaagttt taaagaggcg aaaatagcag aaggattcat taatgtaact
    88501 caagataaaa ctgtcatatt gacagaatct gctgagtgga tttaataaat taatttagag
    88561 tataaaaagt cattttgacc aaaaaaactt ttgggtaaaa tggctttttt gtgttttggt
    88621 gttaataaaa taacgataaa attgtaagtt tttagtgata ataaattcac aaaatgttta
    88681 aatttactgc caaattatgt tgtaattaat aagataaaga agatttagat agcttttatg
    88741 taagtgaaaa agtcttcata taagaaatac atataaaatt tttataaaat ttaaaaaatt
    88801 tgcttagttg tgtagtataa taaataatat aatagatttg tatataatat tcattacaaa
    88861 taattttaaa agttacagtt ttattataat gattattaaa ttaagataag taacataaac
    88921 taaataataa tgtgtattat cgatagtaaa tttataaatt cattattaat tattgaaaga
    88981 agtattataa attttctgga ggaacaatga atatatttga tattggcgta gatataattg
    89041 aaattgatag aataagaaag gctgtagaca aaaataatag gtttttggag aagatattta
    89101 cagatagaga aatagagtat tttaattcta agaattttaa agcagaaagt atagcaggta
    89161 atttcgcagc caaggaagct ataagtaaat ctataggtac aggaattaga gtgtttaatt
    89221 ttaaagatat agaagttctc agagatgaaa tgggaaaacc aatagtaaaa acttataata
    89281 atctagcaaa aatgtgcata gattataatg ttttagaaat aaaagtttca atatcacatt
    89341 caaaagatta tgctatagca aatgcgataa ccataattaa ggactaagga gtgattacat
    89401 tatgatggat aaaacagcaa aagaaataat gacaacagat gtaatagtag caaaacaaga
    89461 tgatagtata gcagatgtag ctaatatgct aattgcagaa aaaataggag gtctgccagt
    89521 tgtagattca gagaatagag ttgttggaat aatttctgaa acagatattc ttaaaaaaga
    89581 aaaatatata gaagcacctc tctatataaa tctattacaa ggattgattt tcttagatga
    89641 cttaaaaaaa gttgaaaaag atataaaaca agtagctgct tataaggttg gagaacttat
    89701 gtctaaagat ataataaagg ttcatgaaga tgataagttt gatgatgtag ctaatgtaat
    89761 gattaaaaaa tcaataaaca gagttcctgt agtagatgat gacaacaaac ttaaaggtat
    89821 aatttgtaga tatgatataa taaaagcttt atacaatgaa taaactgaag taggaggtgt
    89881 gatgtgagaa aaaagtggac catagtatgt attatgttct tggcactggt tataattgta
    89941 ataggatgcc aaaaacgaca gtccacaaaa gaagaagtat acaaagattt tcaaaagcag
    90001 atttctgata tgaattatta cagttgtaaa gctgaagtag aagtagttgg aaataaaagt
    90061 ccacacaatt atgttttaat tcatacttat aaaaaaaccg ataactataa attagaagta
    90121 atttccccaa aacatttaaa agggaaaagt atagaatatc aaggtgataa aatattagtt
    90181 aaaaatccaa agattagtga tgtagtggag ttacctaata caggaaaaaa taatcaatat
    90241 ctttttgtag gagactttat aaaaaactat cttcaaaatg aggagatgaa agtaaagtta
    90301 tccaaaggac atttggtttt agagactttt attcctgggg ataataaata ttttaacaag
    90361 caagtattat atgtaaatgc tgacacaaaa aatcctgaaa aaatggaagt gttagataaa
    90421 gagggagtgc caagatttac agtaaaatac aaagattttg aatacagaaa ctaaggggga
    90481 ctaaagacat gcaaaaaata acagtgccta catgggcaga gataaatcta gataacttaa
    90541 gatttaactt aaataatatt aaaaatttat tagaagaaga tattaagatt tgtggagtaa
    90601 taaaagctga tgcatatgga catggtgcag tagaagttgc aaaattgcta gaaaaagaaa
    90661 aagtagatta cttagcagta gcaagaactg ctgaaggaat tgaacttaga caaaatggca
    90721 taacacttcc tattttgaac ttgggatata ctccagacga agcttttgaa gattctataa
    90781 aaaataaaat aactatgaca gtttattctt tagaaacagc acaaaagata aatgaaattg
    90841 caaaatcttt aggagaaaaa gcctgtgttc atgttaaaat agactcaggg atgactagaa
    90901 taggtttcca acctaatgag gagtcagtac aggaaataat agaattaaat aaattagaat
    90961 atatagattt agaaggtatg tttactcatt ttgctacagc tgatgaagta agtaaagagt
    91021 acacttataa acaagctaat aattataaat ttatgtctga taaattagat gaggctggtg
    91081 taaaaatagc tataaaacat gtatcaaaca gtgcagctat tatggattgc cctgatttaa
    91141 gattaaatat ggtaagagca ggaataatat tatatggtca ttatccatct gatgatgtat
    91201 ttaaagatag attagaatta agaccagcca tgaaattaaa atcaaaaatc ggacatataa
    91261 aacaagttga accaggtgta ggaataagtt atggactaaa atacacaact acaggtaaag
    91321 aaacaatagc tacagttcca ataggatacg cagatggatt tactagaatc caaaaaaatc
    91381 caaaggttct tattaaggga gaagtgtttg atgtagttgg tagaatatgt atggatcaaa
    91441 taatggttag aattgacaaa gatatagaca taaaagttgg agatgaggtt atactatttg
    91501 gagaaggcga agttacagct gagcgtatag ctaaagactt aggaactata aactatgaag
    91561 tgttatgtat gatatcaaga agagttgacc gtgtttatat ggaaaataat gagcttgtac
    91621 aaataaacag ttatttgcta aaataaaacc atgatattat aatctgggag gcgattttgt
    91681 gtacgataag agtaaagaaa aaatagaagt tactttacct gactctctga tttctgaagt
    91741 tgatagtata gttcagatgg agaacagtaa cagagaagat tttgcaaaag ctgcttttca
    91801 gttctatata actcagaaaa agaaaattca tattaaagaa tctatgaaaa cgggttatag
    91861 agaaatgggt caaattaatc tgtcactagc tgaattaggt atgacagttg aagaagtatc
    91921 ttctgatgat aaaaatgaag ggaagattgc ccaaggtgag tactaattgt gaaataaagc
    91981 gtggtgattt atattacgct gatttaagtc cagttgttgg ttcagagcag ggaggcgtta
    92041 gacctgttct gataatacaa aatgatgtag gtaataaata tagtcctaca gttatagtat
    92101 cagctataac atctcagatt aataaagcca agttacctac tcatgtagag ataagttcca
    92161 atgaatatgg gcttaataaa gactcagtaa ttcttttaga gcaaattaga actatcgata
    92221 aaaagagact gagggaaaaa attggttgtc tagatgaaaa tatgatgata aaagtagatg
    92281 atggacttca aataagttta ggattgttta ctttttaaag agggatttgt cttttattag
    92341 acaatccctt ttttctttta aatatctctt aaggtttaat tttaatgtac tatgttaata
    92401 aaattaaaaa taacgcaaaa aaatagcata aaagtgatat aataatatgg aattgatata
    92461 aaattacgaa ctcaagggag gtaattgcat gagagaccat aaaggattaa atgagattgc
    92521 gcgtatcata agaagagata tagtttcaat gatacataga gccaaatctg gacatccagg
    92581 agggtcatta tcagtagttg aaatacttac tgcgttatac tttgatgaaa tgaatgtgga
    92641 ttcttcaaat cctaaaatgg aggatagaga tagatttgta ttatcaaaag gacatgctgc
    92701 accagcatta tatgctacat tggctgaaaa aggttatttt gataaggaag aactgaatgg
    92761 attaaggaag ataggaagga tgttacaagg tcatccagac atgaaaggca cgccaggtgt
    92821 ggaaatatct actggttctt taggtcaagg tttttcagtt gcatgtggta tggctatggc
    92881 atcaaagttg gataatgctc cgtggaatgt gtatactttg cttggtgatg gtgaggttca
    92941 agaaggaatt gtttgggaag ctgctatgag tgctgcacat tataaacttg ataatttaat
    93001 tgctttttta gataataatg gacttcaaat agatggagat atagaaagcg taatgagttt
    93061 aggttcaata gttgataaat ttaaagcttt tggttggaat gtaattgaga tagatggaca
    93121 tgattttgac caaatatttg cggctcttga tatagctaaa tcaacagtta aaaaacctac
    93181 aatgatagtt gcaaaaacta taaaaggcaa aggaatatct tttatggaaa atcaagcagg
    93241 atggcatggg acagctccaa gtgatgagga gctagaaaaa gccttgcttg aattaggagg
    93301 tgctgacaat gagtaaaatg gcgacgagag aagcatatgg taaagcatta gtaaaattgg
    93361 gtcaaataaa tgacaatgtt gtagtattag atgcagattt atcaaagtct acaaaaacac
    93421 atgattttta caagtcattt ccagatagat tttttaatat gggtatagct gaacaaaatt
    93481 taataggcgc tgcttgtgga ttatcaactg ctggtaaaat accttttgca agcacttttg
    93541 ctatgtttgc tacgggaagg gcttttgaga ttataagaaa ttcagtttgt tatccaaagc
    93601 taaatgtaaa aatatgtgct actcatgcag gtcttactgt tggagaggat ggagcatctc
    93661 atgaaagtgt ggaagatatt gctataatga gagctatacc aaatatgaca gttcttgttc
    93721 cagctgatgg agttgaaaca gaaaaaatta tttttgaaat agctaagtat aatggacctg
    93781 tttatgttag attagggaga agttcagtac cagttttatt tgatgaagat tataaatttg
    93841 aaataggaaa aggtacagtc ttaagagaag gaaaggatgt atcaattata gcttgtggaa
    93901 ttatggtaaa tgaagctcta ttagcacaag aaaagttgca agaagaaggt ataagtgcta
    93961 gagttataaa catgtcctcg ataaaaccta tagacaaaga tttaatatta gaatcagcaa
    94021 aagaaacgaa tgctattgta actgtagaag aacatagcat aattggggga ttaggttctg
    94081 ctgtaagtga ggtagtagga gagtcttgtc caaccattgt aaagaaagtt ggaattaaag
    94141 atacatttgg agaatctggt actccaaatg aattgttaaa aaaatatgaa ttaacttgtg
    94201 atgacataat aaagactgtt aaagaagcta ttattgcaaa aagaatgtaa gagatataaa
    94261 ttattcatgt ttgttaataa tataatatat ttaaaagaga ggtataaagt gttatattaa
    94321 tttatatctc tctttttttt atatgatatc aatatatcaa aaatgtaata aaatattcaa
    94381 atttttacaa aaatagagaa aatattcaaa tatatattga ctattcagaa aaatatgact
    94441 aatatataat ttatagagaa actaatttta tatataatga ctacttagat aaaagaatct
    94501 aaaaaaatta tgagaggagg agtagggtat aaaatcagat tataagtttt aagttattat
    94561 actaaaaagc tataaaacag ttatcatgta ttttatgtta aaggaaattg taggtagttt
    94621 atcgaattgt ttaatcagaa gaaaaaattt cacatgggga ggtaactgag atatgtcaga
    94681 aaaagtaaat gttaaaacag tcatcagttt cgcaggtgcg tatgtagcaa cagtaatcgg
    94741 ttctggattt gcaacaggac aggaaataat gcaattcttc tctttttatg gttttgcagg
    94801 tattattggt gggataattt caatggtatt attctcatgg atgggtgctt cagttatgtc
    94861 aaaaggtaaa gagcttcaac ttaaagaacc tatcaaaatt tatcgtgttt attgtggtaa
    94921 gtatttagga atattctttg aatggtttgg acctttattc ttatttggtg ttttcgtagt
    94981 aatgatttca ggagcaggag caactttaac tgaatactat ggattaaatc catttgtagg
    95041 tagagtaggt atggcagtag tagcattatt aactgtttca ctaggtcttg ataaattatc
    95101 aaagatacta ggtggaatag ggcctataat aataatcttt acacttttag ttggtggtat
    95161 aagtttagct aaaaacatag gtaatatagg agaagctgca caagttctta gcactgtaaa
    95221 gatagctaaa ccagttccaa atgcctatct atctggtgta atatatacta cttataacac
    95281 aattgttgtt atggcattct taactggatt aggagcaagt gctgctaaca aaaaagaagc
    95341 tatttgtggt ggtatattag gtggagtagc acttatggct gcagctataa tgatgcactt
    95401 agctattctt tctgatatag gaaacttata ttcaaaagca ataccatcat tattcttagc
    95461 agataagatt tcaccagtaa ttggagtttt attctcaata attcttatat taggtatata
    95521 tacaacagct gtacctttat tatggtcagt aactaataga tttgtagatg acaaacatcc
    95581 taagtttaaa ttaataactt taatagcagc tatattaggt cttataggtg gcttcctacc
    95641 atttgataag ctggttggta ttttatatcc atatactgga tatatgggcg tcataatact
    95701 ggtttgtgtt ctttatagac agattacaaa aacatctgga tatcaagaag gaatcagtga
    95761 caaataagta ttttttaata ttgtaaactc aagagctata tgaaaacaat gaaaatgttt
    95821 tcatatagct ctttttattt tttagctcgt ttattatgaa atagaaaaaa catgtttttt
    95881 agttacatta catatattta taattatgta taaatatata ctaatcaata atttagagtc
    95941 taagataagt ttataaatca tatatttaga atatatggga ggagtgataa gattgaatgt
    96001 aaagtttaat attaaaggta taatttatgg agttatagct cttgtattcg ttataggggg
    96061 atttatattc ataccaagta tgtttgtaga gaaatctaaa cccatagatt atacagtatt
    96121 acaaagaaat tcaataccag aaaagatatt agatgtgatg gataagtata caaatgaaga
    96181 aagagcatta gcggctaaaa tcgataacaa aatatacatt atagtgacta gaggaaataa
    96241 taaatatggt atagaaatgg acaaaataga aagtgtggtt gaggaaggaa aggatgtttt
    96301 gagagtcaag ataaagtata aagataagga agattctttt ccatacatag ttgttgaaac
    96361 aaatatgagt gaacttccag atagaataga attaaatgcg acgaaataag aaggtatttt
    96421 ataattaaat aactgcatat tgtacaataa agtcatggtt tttattaatg taagtaaatt
    96481 gtgtatggtt cttattgttg taaaagccat gacttaaaat gcttataaag taagatatta
    96541 acagtagtat ttattactac attaaatggg gtctggaaat acttaatatt ctaactattt
    96601 ggagtgataa ttctagtttc agtaactatg tagtctaatt gtgcatcatg agtttctttt
    96661 ggaatagaat cgaatatctg gaagtcaaat gctatgccga tagttatagc atcttttctt
    96721 aagttttcta aaaatctatc ataaaatcct ccaccatatc ctaatctata gcaatgtata
    96781 tcatatgcta cagctggtac aattacaaca tctaaggcct taatatcaat tgtaggtgat
    96841 ttttcgttag gttctcttat tccatatgct ccaattctca atccctcttt taaatctgtt
    96901 atttgagtag ggattaatgt atgattttct tttattgtga tgggacttga tactattttc
    96961 tttagagaca aaagtttttt gattaaatta tctgtttgaa cttcattgtt aaaatttaga
    97021 taaagcatta tattagttgc atttcttata tcttccattt gaagtaattt ttcagttatt
    97081 aaatttgaat tactaagtac aaagtttgca ttcttatttt ttcttgattc aataactttt
    97141 tttctaaatt cttttttcat aaaataattc ctcccttaat atgttataat gtgtacagca
    97201 attgtattta atataaattt tagtataatt tattgtaata aagcaatata tttgggtaaa
    97261 tgtaataaaa ataacagcta gtcatataat aataatagtt tatgtaaaag gagatgtatc
    97321 ttgtgatttc aaagaagaaa gctatttttt taggggtgat tttagtaatt ataacagcta
    97381 tggttacatc agcatttcag ttgacattgg ggaataaagt tgtaatatcg aaagaactct
    97441 atgaagacta taaaaaatat gataagttgt taggactaga atctattata aaacaagatt
    97501 tttataaaaa agtatcagat actgatttgg taaatggagc agcaaaaggt ctatttctag
    97561 gaacaaatga taagtattct ggttattata ctaaagatga aatggagaat ctaattaatg
    97621 atagtgaagg ttcttatgtt ggtgtaggta tgtatatagg ggcatcaaaa gatggtggct
    97681 tagtagtagt tcccatgaaa gattctccag cagagaaagc cggtgtaaaa tcaggggata
    97741 aattagtaaa agtcaatgga aaatctgtct catataaaaa ttcagatgaa gctgttcgta
    97801 tgatgaaggg taaaaaaggt aaaacagttg aactgactat attaagagaa gataaacaat
    97861 tgaactttaa agtaaaaaca gaccagataa ttgagaagag tatagaaagt aaagtaattg
    97921 ataatgattt aggatatata gaaattaccc aatttatatc aagtacatat actgactttg
    97981 ataaagcttt aaaagaatta aaagcaaaaa atatcaaggg attagtaata gaccttagaa
    98041 ataatcctgg tggaatgcta gatatatgta aagaagttgc tgatgagtta attggtgaag
    98101 gaactatagt atatacaaaa gataataagg gaaatactga gtacttgaaa tctgataaag
    98161 aaaaattggg acttccaata gtagtgttaa ctaatggaga aagtgcttct gctgctgaaa
    98221 tattaacagc tgcaatcgtt gataataaag aaggtatttc tgtagggact acaacttttg
    98281 gtaaagggtt ggtacaatca gttgtaagat tgaaggatgg aacaggatac aagctaacta
    98341 ctgctcaata ttttacacct aatggggatt atatcaatga aaaaggtata aagcctacta
    98401 ttgaagagaa agatgaaaat aaacagttag atgtagcaac taagtggctt agagaacaga
    98461 ttgataaata ggatttaatt tttataaact tatactataa aataaagaac attataaaag
    98521 agatgtctca aaatgaactt tttagttcat gagggagtct ggaaatattt atgtgtattc
    98581 tttaaataaa aatttatttt ttaagtgata attaaatttt tacagacagg gctatggttt
    98641 taaaaatcat agccttattt tgatattttt taaaaacata ttgcaaccca gttgttccaa
    98701 atattatatc atttactttt aaaa
//
LOCUS       DAEPID010000004        98555 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.004, whole genome shotgun sequence.
ACCESSION   DAEPID010000004 DAEPID010000000
VERSION     DAEPID010000004.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 98555)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 98555)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..98555
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.004"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            154..621
                     /locus_tag="KR257_000294"
     CDS             154..621
                     /locus_tag="KR257_000294"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012816325.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0029023.1"
                     /translation="MKMLNGIIKLFYSEIVKTKINNLDSSGYSLRDECKEIRNITLKI
                     DSVFFKLLKLAFGSILLMVAFNLNMVLGIGVFLVGVVYILYKRNMEEQVKEHINNVKN
                     NIDISKITFMDEKGRTGLNALITLLLIGLLTGFNWILVASFVVVFVFTIKNVC"
     gene            664..2427
                     /locus_tag="KR257_000295"
     CDS             664..2427
                     /locus_tag="KR257_000295"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003427079.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SpoIIE family protein phosphatase"
                     /protein_id="HBH0029024.1"
                     /translation="MTNGSYKMKNLVEISAMVTESTDFFNIKDDIIEKMLEVVHPTKA
                     CVNLFYKNDSKYAYLVCSQTLEYVPQIFPINSLKGAKIDFDTYPEYIHEAVNEKKIIY
                     VENVFEDSRAEGERDLAKAEGYIGRIVFPFIINNVVVGFMTCFLKEDDYITEQDIDFI
                     SSVASLLSLSIEITNKNNNVQILIDKLRGSISAINEATKKLYLNKSIDGFLENLSKQA
                     CNITNSKEALIIINSHHNKDAIVSCYNVEQKKKTNLYPMIDMFLKKESLGGYLNNLKP
                     CSKKGINLESYIYYKLQDKNETIGCIVCANSKNYTSDDLNILSILSKQVSVGMQLYEH
                     NEKEVKHKVLENELNILNKQQQLIMDKGKMDCNDEKELYFYHKPARVVGGDFYYATKV
                     DDEHIVYIVADVMGHGMVSNYVVAMIKGAFKVLCNQYNTPREIMTNLNRMLYDEFDKM
                     GVFTTCLIGIIDTKENMITVSNAGHYSPVVVKKDGTIENNLNCKKGIPIGIMEDATYE
                     NNTLSMEDYAMVCMYTDGILEIKNSSKEEYGINRLENFLKENFRLNQQLIVENLKLDL
                     KNFSSKDNYDDDILIVMLKDR"
     gene            2435..3043
                     /locus_tag="KR257_000296"
     CDS             2435..3043
                     /locus_tag="KR257_000296"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890914.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flavodoxin family protein"
                     /protein_id="HBH0029025.1"
                     /translation="MDSNDKKGLKSPEIIIINGSPRINKNCSFIANEVKAMLEECGLS
                     CKIFNIYNMDIEYCTACGFCEKTGYCKFNDDMKPLYKMFDDSKGTIVISPVHFDSISA
                     KLKTVVDRTQAIYASKYVLNKPSIDRSKKRIGMYIAVGGSKSYDSQFKGGQIVMDFFF
                     KSINTKLLHNIYLNNTDDVSYIDNQEFKDIIYKNLKIYIDSI"
     gene            3115..3684
                     /locus_tag="KR257_000297"
     CDS             3115..3684
                     /locus_tag="KR257_000297"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861641.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphate propanoyltransferase"
                     /protein_id="HBH0029026.1"
                     /translation="MKLPIALSNKHVHLSQADIDVLFGAGHELTKFKPLSQPGQYACE
                     EKVDLVGPKGTLKGVRVLGPARAHTQVEISLADGFPLGVKAPIKESGDIAGTPGVKLV
                     GPAGEVEMKEGVIVASRHIHMSNEDAAKFGVTDKQIVKVKTSGPRALVFENVLVRASD
                     SFNLEMHVDMEEGNAAGVKNGDLVELIVD"
     gene            4202..7741
                     /gene="nifJ"
                     /locus_tag="KR257_000298"
     CDS             4202..7741
                     /gene="nifJ"
                     /locus_tag="KR257_000298"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009900447.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pyruvate:ferredoxin (flavodoxin) oxidoreductase"
                     /protein_id="HBH0029027.1"
                     /translation="MAKFMKTLDGNTAAAHVAYAFTDVAAIYPITPSSTMAEVVDEWA
                     SQGRKNIFGQTVNVVEMQSEAGASGTFHGSLQGGALTSTFTASQGLLLMIPNMYKVAG
                     ELLPGVFHVSARALASQALSIFGDHQDVMAARQTGCVLLASGSVQEVADIAPVAHLAA
                     IEGRLPFIHFFDGFRTSHEIQKVELLENEDYASLLNFEAVQAFRDNALSPNHPVARGT
                     AQNPDIYFQTREASNKYYQNIVGIVEKYMEKMSNLTGRKHSLFDYYGAEDAKYVLIAM
                     GSVTETIEETIDYLNAKGEKYGLVKVHLYRPFSMKHFLDAMPSTVERICVLDRTKEPG
                     STGEPLYLDVRDVFYGKENAPMIIGGRYGLGSKDTTPSDIKTVFDNLVSEQPKNGFTV
                     GIVDDVTNTSLTPSEPIKIASKGTIRCKFWGLGSDGTVGANKQAIKIIGDHTEKYAQA
                     YFDYDSKKSGGITMSHLRFGDTPIRATYLIDEADYIACHKQSYVYQYDLLKGLKKGGT
                     FVLNTIWDQAGLEEHLPAHMKQYIAKNDIKFYTVNAVKLGQEIGLGNRINMIMQSAFF
                     KLAEIIPEEDAVKYLKDSIVKAYGKKGEKIVNMNYAAVDAGINALVKVEVPASWENAV
                     DADKGEVKEPEFIKNILRPMTAQEGNNLPVSTFNGIEDGTFPCGTAAYEKRGIAVDVP
                     EWIIDNCIQCNQCSFICPHSCIRPVLVTEEELANAPEGFEAKKALGKGLEGLKYRMQL
                     SPLDCTGCGNCADICPAKEKALVMKPIDTQLDTELDNWAFAVNPDEVAPKGDVMPANT
                     VKGSQFRQPLMEFSGACAGCGETAYIKVVTQLYGDRMMIANATGCSSIWGASAPSIPY
                     TCNHEGKGPSWANSLFEDNAEYGFGMYTAVKQIRNKIVDAMTELVSMDICEDAKAVFT
                     EWLDSRNDGEASKVASAKVVELLEKPACDCTDEKAKELVKAIKDRKDYLVKRSQWILG
                     GDGWAYDIGYGGLDHVLASGEDVNVLVFDTEVYSNTGGQASKATPAAAMAKFAASGKK
                     SRKKDLGMMAMTYGNVYVAQVAMGADKNQFIKAVIEAEKHDGPSLIIAYAPCINHGLK
                     EGMGRTVANEAQAVACGYWHLYRFNPEVKAEGKNPFTLDSKEPTASFKDFILAQVRYS
                     AIAKQFPEEADGLFAKAEADAKERYEGYKKLAE"
     gene            complement(8133..9029)
                     /locus_tag="KR257_000299"
     CDS             complement(8133..9029)
                     /locus_tag="KR257_000299"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018112861.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sporulation protein"
                     /protein_id="HBH0029028.1"
                     /translation="MMRRNIPTKLKTILALGVLTLATASSAVTASASSLENNVNISNK
                     SLVYSNTKYKFSAKPNCSVKPELKPDKDNSCKDKNHNDKNCNNTNKPEDNNNSDSTNK
                     PGNNKPESNKPEDNNNSGSTNKPDNNKPESNKPEDNNNSGSTDKPEDNNNSDSTNKPD
                     DNNNSGSTSESFSAYQKEVVDLVNIERAKAGLNPLTLDSSISNVATKKSQDMIDNNYF
                     SHNSPTYGSPFDMLKKFGISYKTAGENIAMGQKTPKEVVNAWMNSEGHRKNIMNPNFS
                     KIGVGVAQKSGGSIYWTQIFVG"
     gene            complement(9525..10859)
                     /locus_tag="KR257_000300"
     CDS             complement(9525..10859)
                     /locus_tag="KR257_000300"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728489.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GntP family permease"
                     /protein_id="HBH0029029.1"
                     /translation="MSIIAPIGIIIGIIAIIYFSVKEIHITIAAPIATLIVVILNKMD
                     VVTSMLGADKNNYMGALGNYIMSYFAIFLLGSILAKFMEESGATVSIADFILNKFGSN
                     HPYRVLVAIFIVSFILTYGGISLFVVMFAVIPLARTLFKKLDISWNLIQIPLWLGIAT
                     ITMTIIPGTPAIQNVIPIQYLNTSLTAATIPSIVGSIGCATFGLVYMKYALNKSIRKG
                     ETYATYTSELEEESLDRELPGFFASIFPLLALVIIAITGSTFGSEFMKKNVIYIALIV
                     AILLSAFLFHKFLSSKIQTLSIGASGSIGPIFATSSAVAFGAVIMAAPGFDVFSKLIM
                     SIPGSPLISLTVLTSTMSAITGSSSGALGIVMPNFADYYLSTGLNPELIHRVATIASN
                     ILTIVPQSGVFLTFLSLSKLTHKTGFKETFIVVAVGSLIAEIIVITLGLLMY"
     gene            complement(10921..11697)
                     /locus_tag="KR257_000301"
     CDS             complement(10921..11697)
                     /locus_tag="KR257_000301"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890906.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="3-hydroxybutyrate dehydrogenase"
                     /protein_id="HBH0029030.1"
                     /translation="MVKDKVVFVTGAASGIGKQIAESFLKNGAKVMFSDINQEALNNT
                     ITELQKKGYDCMSVKCDVTKEEEINHAIDKTVEKYGRLDILINNAGLQHVSMIEDFPT
                     DKFEFMIKIMLTAPFIATKKAFPIMKKQGFGRIINMASINGVIGFAGKAAYNSAKHGL
                     IGLTKVAALEAADSGITVNALCPGYVDTPLVRGQFNDLSKTRNIPLENVLEEVLYPLV
                     PQKRLLDVQEIADYAMFLASDNAKGITGQACLLDGGYTAQ"
     gene            complement(11802..12467)
                     /locus_tag="KR257_000302"
     CDS             complement(11802..12467)
                     /locus_tag="KR257_000302"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416028.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="3-oxoacid CoA-transferase subunit B"
                     /protein_id="HBH0029031.1"
                     /translation="MDKLEMQEYIANRVSKELKDGAVVNLGIGLPTKVANYIPDNVNV
                     ILQSENGFLGLGSAEDGNSSDETIVNAGGQPVTILPGGCFFDSATSFGIIRGGHVDIT
                     VLGALQVDKYGNIANYMIPGKMVPGMGGAMDLVTGAKKVIVAMEHTSKGSAKILNNCT
                     LPLTATNAVDLIVTEMGVMEVTSDGILLKEINPAFTLDDVISATEAPLILSDSLNGKI
                     SVV"
     gene            complement(12467..13123)
                     /locus_tag="KR257_000303"
     CDS             complement(12467..13123)
                     /locus_tag="KR257_000303"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003427064.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CoA transferase subunit A"
                     /protein_id="HBH0029032.1"
                     /translation="MNKIVSIDEALSHVKDGDTIMVGGFMANGSPENLIDYLCSKNIK
                     DLTLICNDTGFIDKGVGKMVVNKQFKKIIASHVGLNKETGRQMNNNETDVELVPQGTL
                     AEQIRAAGYGLGGILTPTGIGTLVEEGKQKIVVDSKEYLLEKPIYADVALLFASKVDK
                     AGNLVYKGSMNNFNNLMASAAKITIVEADEIVEIGDIDPNEVNTPGIFVNYIIEGGNL
                     "
     gene            complement(13132..14310)
                     /locus_tag="KR257_000304"
     CDS             complement(13132..14310)
                     /locus_tag="KR257_000304"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000786547.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="acetyl-CoA C-acetyltransferase"
                     /protein_id="HBH0029033.1"
                     /translation="MKDVVIVSAVRTPIGSFGGVFKNTSAVQLGTITVKEAISRVGLN
                     LSEIDEVIIGNVLQTGLGQNVARQIAINAGIPNSVPSYTVNKLCGSGLKSVQLAAQSI
                     TSGENDVVIAGGTENMSQAPYIVPTARFGSKMGDITMVDSMLTDGLIDAFNQYHMGIT
                     AENIATKFEFTREMQDKLALESQSKAENAIKNNRFKEEIVPVDVLIRRGKIETIDKDE
                     YPKLGMTFEGLAKLKPAFKKDGTVTAGNASGINDGAAMLILMSQQKADELGIRPLAKI
                     KSYASAGVEPEVMGTGPIPATRKALKKAGLSINDIDLIEANEAFAAQALAVKNELQID
                     SSKLNVNGGAIALGHPIGASGARILVTLIYEMQKRKVETGLATLCIGGGQGISMVVSR
                     "
     gene            14665..15567
                     /locus_tag="KR257_000305"
     CDS             14665..15567
                     /locus_tag="KR257_000305"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416031.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LysR family transcriptional regulator"
                     /protein_id="HBH0029034.1"
                     /translation="MDIKQLKYFVEIVKSGFNLSIASKTLHISQPALSQIIKNFEESE
                     DVYLFERYKGRLNGLTPAGERFYVNAEHIINEYKNMMEDLREDSVQFKGKVRIGIPPL
                     ILGIAFSDVVAQLVANNPDIEFDIVEKGAYDLNRMLILQELDYAVLLHPHKIDKSVVT
                     EHVLQEDELTAFLNINHPLAKKDKIDWNDLNEQLLAIFNPTFMIHHKLMQKFTDENVK
                     LKRYIMSGSWDFLLLSTTNSDFITILPSPVHDFFENSKIIEKPFNHPITWKVILCRPK
                     KERYSHVDQHVFKFIIDFFSKKNS"
     gene            complement(15783..16595)
                     /locus_tag="KR257_000306"
     CDS             complement(15783..16595)
                     /locus_tag="KR257_000306"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416032.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBH0029035.1"
                     /translation="MFTSILKKLKKDKSFAFACITLSIIIILIIASFILNIDSNAIDT
                     TSKLQEPSLKHIFGTDELGRDYFSRALYGGRISLSVGILSMLISVVFGTAVGVISGYI
                     GGKLDQFLMRLIDMLMSIPSFLVLIVLNTYLTPKVSTIILIIGFLSWMEVSRIVRGET
                     LKIKENEYCLAAKATGIKTRNILLRHIVLNLKETIVVAGSLNIANAILTESALSFLGL
                     GIQLPLASWGNMLQDAQRHIFDKLYLAVFPGLLIFLTVMSLTIISKKFSSNT"
     gene            complement(16598..17557)
                     /locus_tag="KR257_000307"
     CDS             complement(16598..17557)
                     /locus_tag="KR257_000307"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897855.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBH0029036.1"
                     /translation="MLKLILNRVKVLIPMLILISILSFGLLELAPGDPADAYINPLMS
                     SQDIENIRVNMGLDKPVYIRYLNWLKNTLSGNLGISYINHMPVTEQIMEKMGNTFILM
                     GTSLIFSILVAIPLGIFLAVNKNSITSKVSSVFNYIGVSIPSFWIGMILISIFSVKLN
                     IFPSGGMHTIGNDSIGDLVKHLVLPVITLGLYNTAIFTNYVEASVNEQLKKQYVITAR
                     AKGLSEKVILFKHVLKNSLTSLVTILGMSIQKLVTGAFVTEVVFSWPGMGRLMIDSIF
                     SRDYTVIMAITMLSALFLILGNLVADILYLLIDPKIKSSKGGF"
     gene            complement(17663..19222)
                     /locus_tag="KR257_000308"
     CDS             complement(17663..19222)
                     /locus_tag="KR257_000308"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003427055.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="HBH0029037.1"
                     /translation="MKFKKLASLILVSSLMLTFTACASNDKDKSSGSKSGGTVVIPMA
                     SDPDIINGAFANVKEDSLASNIVYAPLYTYEKGNLVNYLAEKVDFKDSKELTIKLKSN
                     LKWHDGKPITAEDVLFTFNTVLDEKQNSPSRQYLLVGEKPVKVEKIDDLTVKITLPTA
                     SESFLYGISKISPIPKHVFEGESNIAKSEKNNNPVGSGAFKFKEWKKGESIVFEKNAD
                     YFGGEPKADSIALKIIPNEASQEAALNNGEISLMKTSAEGYEKAKSNSNLQTYTYSEE
                     RLNYIVFNQNISNMANKEVRQALSYALNRNEMIESAYGKEGSVPAKSILVPEADFYTE
                     EGVEGYDQDTNKAKDLLDKSGVKIDKLKIGYNTGRFGHKNYALVAQQELKKIGIEAEI
                     VPYESKAFFNILFSNSTECDMYVNGYAWGLEPNPYRGMFETGQYCNQTKYSNAEIDAL
                     WEKGFTELNKEKREEIYKQIQQDISKDAPIYTIDYEQNLMAAQKNLKGIKDAKPSPAI
                     LFEDWSKLYVE"
     gene            19441..20418
                     /locus_tag="KR257_000309"
     CDS             19441..20418
                     /locus_tag="KR257_000309"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454983.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBH0029038.1"
                     /translation="MSKALIEVKDLKVYFHTDKGIVKSVNEVSFNINEGETIGIVGES
                     GCGKSVTAMSLMKLLPTSKIEGGEIIFRGKDILKMNEDELMGIRGNEISMIFQEPMTS
                     LNPAFTVGSQIIEGIMIHQDLSKEEAKKKVIDMIKLVEIPRAEEIYNSYPHELSGGMR
                     QRIMIAMALSCNPKLLIADEPTTALDVTIQAQILDIMKNIKEKLNTSIMMITHDLGVV
                     AEMCDKVLVMYAGKIIEVAEVVELFKNPKHPYTIGLLKSKPALGKNKDKRLYSIPGQV
                     PNPIGMPDSCYFSDRCEKVCDKCRTQIPPLIELNSGHSIACWLYKKEEI"
     gene            20419..21390
                     /locus_tag="KR257_000310"
     CDS             20419..21390
                     /locus_tag="KR257_000310"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003427052.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dipeptide ABC transporter ATP-binding protein"
                     /protein_id="HBH0029039.1"
                     /translation="MKKEESLLKVEGLKKYFEVKSGLFDKKIKSVKAVDGISFDLKKG
                     ETLAIVGESGCGKSTAGRTILRLIEKTEGKVEFNGVDIYKLEKEELRKLRPKMQMIFQ
                     DPYSSLNPRLNVEQIISEAVIEHNLVPKNEIKDNILNVVESCGLSKYHLNRKPGEFSG
                     GQRQRIGIARALALNPEFIVCDEPVSALDVSIQSQIINLLMDLQDKYKLSYLFISHDL
                     SVVNHIAHRVCVMYLGSIIEIATKGELYLHSQHPYTKALMSAVPIQDPTIKKNRIILK
                     GDIPSPTNPPSGCKFHTRCPYCKEICKKEIPVLKEISRNHFVACHLV"
     gene            21542..23584
                     /locus_tag="KR257_000311"
     CDS             21542..23584
                     /locus_tag="KR257_000311"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728484.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sodium:proton antiporter"
                     /protein_id="HBH0029040.1"
                     /translation="MSILVTLLGLLVCTTISTVFSKKWSNIPLAIYQIVLGIILSILP
                     FKFSFSFNPEIFVICIIAPLLFSEGQNVSRKELLELRKPILLLAFGLVLITVFAGGIF
                     IHFLIPGMPLSVSFALAAVISPTDLVAVKSITQGLNFPKNIMSILEGESLLNDAAGVV
                     AFKVAVLATVTGVFSIEEAGIQFMITAFGGIIVGSILGYIIIKIRLSLHKWNLEEIPM
                     VIVIQIMTPLFVYFVAEEIGVSGILAVVMAGIAHGIEKEHLQNTTTKLRIISDNTWYV
                     LEYVLNGFVFTLLGFLLPSIYTGLSSKNENMALELTFISTLIVLILFVIRFIWVYLWH
                     NSFIKPKKNPLNNFFVGFLGFKDEEVIKESISKCKYSLIVATCGVHGTFTLATALSIP
                     FYLADKDVFPMRDTVLFISSEVILISLVLATILLPRLLKNNVQESEPLLSDKEAYKLI
                     LKEAILKLSNEKAQEVQPVIHDLNEQLVDSEKGILNTPDNKLISMMIAEADQQGLLAV
                     LKLLEDGKISDRAFKLYRFYITKSRKSVQKSIFKIVKLKISMWIINRKVKKEVKEKIT
                     KIVSENKEIIKEFHHAYALSTKTAISFINKNTDEDNRHEALIAIRFYNRYLNWITRKI
                     QNDDKFEARVEYYRVMAIQSQRDSVQQLVETKQISREVAKELLENILYDEMMMIES"
     gene            23845..24687
                     /locus_tag="KR257_000312"
     CDS             23845..24687
                     /locus_tag="KR257_000312"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897844.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PRD domain-containing protein"
                     /protein_id="HBH0029041.1"
                     /translation="MIIQQIYNNNVVLVLDENIKKELILTGCGIGFQKKKGQEIDKSK
                     IERTFVIQDESFLDKISKLASQVDEKFFEVSTEIIAYAEENLNTKLYEYIYVALTDHI
                     AFAIKRYHENITIKNDLLHEIKRIHKKEYEIGKWAVDYINKEFDVKFPVDEAGFIAMH
                     IVNSNYKGSSKESLLITKIVKDILNIIRYYYRVEFKEDDINYDRLLTHLKFFAKRLVK
                     KEKINDTNNEIIDIIKVKYEKDYDCAYKIKTHVEKNYDYYVSQDELLYLTLHIKRVIS
                     VLNL"
     gene            24990..27062
                     /locus_tag="KR257_000313"
     CDS             24990..27062
                     /locus_tag="KR257_000313"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416039.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS transporter subunit EIIC"
                     /protein_id="HBH0029042.1"
                     /translation="MKKVFGVLQKVGKSLMLPVALLPAAGILLGVSNALAGDALLAHF
                     PALANPTFQLIISIMESSGQIIFNNLPLIFAVGVAVGLTEGEGVAALAAIVGFLILNT
                     SMGVMAGVTEDMVDNSMYANIVGIPTIQTGVFGGIIIGIVAAYLYKKFYKIELPQYLG
                     FFAGKRFVPIVTSLVAIAIGIILSFIWPPIQEGLLSFSKNVIEANQTLAAFMEGSLER
                     LLIPFGLHHVFHNPFWYQFGEYVNKAGELVMGDQKIFFAQLKDGVNFTAGTFMTGAFP
                     FMMFGLPAAALAMVHEAKPEKKKFVAGIMASAALTSFLTGITEPIEFAFLFVAPVLFA
                     IHCLFSGLSYAIMQLLGVKIGFTFSGGLIDFLLFGVLPNRTPWYLAILVGIGFAVLYY
                     SVFRFMIRKFNLKTPGREDESETNAEVIEMSKNELASEILIALGNKDNLKSLDACITR
                     LRLVVNDINKVDKEKLKSLGAAGVMVIGNNVQAIFGPKSDSIKSDIKDIIEGKTKVES
                     TVTKNVDKNKVKKNMEVANMENALVEKIDSLTNGEILDIEEVPDSVFSSKLMGDGFAI
                     KSSDGLIYSPVDGTIGVIFPTKHAIIIKSQKSGVEILIHLGIETVNLEGNGFEVFVNV
                     GDEVKAGEKLVKMDLEYIEKNGLSTISPVVFTNLEQNQKLSIKKGVSTAKEENRVSIL
                     RDDIEKIG"
     gene            complement(27275..28144)
                     /locus_tag="KR257_000314"
     CDS             complement(27275..28144)
                     /locus_tag="KR257_000314"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897841.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="HBH0029043.1"
                     /translation="MDNKIGYLNDNFKIFNIRDKKDIQFEYHNHDFNKIIIFINGNVT
                     YFVDGIPYKLKPWDILFISNNEIHKPVIDSNVFYERIAIWISPEFMKKNSDASSDLEK
                     CFKIATENKCNRLRLNIHDIESIKSFIEQINISESNTEFGNEILRNALFIQLMIFLNR
                     IFLKNENMESTEDVFYDETIKKVLNYINSNIDDKLSIDSISSEFFISKYYLMRKFKSH
                     TGTSIHNYIVQKRLILAKSLITNGHLMSEVCNKCGFNDYSSFVRAFKKNYGVSPKNYI
                     NNKNPLDITLLDE"
     gene            28308..29762
                     /locus_tag="KR257_000315"
     CDS             28308..29762
                     /locus_tag="KR257_000315"
                     /EC_number="6.3.2.13"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454974.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,
                     6-diaminopimelate ligase"
                     /protein_id="HBH0029044.1"
                     /translation="MKLNDIIQGLDIINIKGELNIDINNVQYDSRKVTKGTLFICIKG
                     FVSDGHKYIKDAIEKGASAFLVEEDVEIKGCTFIKVKDTRKDMAKVADNFYNHPSQKF
                     NVIGVTGTNGKTSITTILNEILTLNKNKVGLIGTIKIFDGEKDIVSNSTTPESIDLQY
                     HFNNMLDNGCDYCAMEVSSHSLALNRVDETDFKLGIFTNLTPDHLDFHKDLEDYRKAK
                     EKLFFKTTMANIINIDDEGGKKIYENIKGINVPCYTYGVDTKADFMARDIKSDSDGVS
                     YRLITPSYEEVIFIPVPGMFTVYNTLAVIAACYVLGIPKPIYKEGLRLSNGVSGRFET
                     VPNDKGISVIVDYAHTPDALENVLKTTQQFAEGKIISVFGCGGDRDTEKRPLMGAIGQ
                     KYSDLCIITSDNPRTEEPEAIIKDILEGIDKKKENYHVVVDREQAIAEAISMAKKDDV
                     VIITGKGHETYQIIGKVKHHFDDKEVANECLSKM"
     gene            30033..32312
                     /locus_tag="KR257_000316"
     CDS             30033..32312
                     /locus_tag="KR257_000316"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897838.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="EAL domain-containing protein"
                     /protein_id="HBH0029045.1"
                     /translation="MLSDAKNNRYGLSIIAVISILVITISCLIYGSRLNKTLGEETNQ
                     YLSEIANQSVNVLKKQINGDIKLLESISIFIEGEESFEVDNILSILKRQAINSSFKRM
                     GVILPNGTAYTTDGYIEDFSKRDYFLKSMQGEVVITGKLKDVIEDDKNTNSNINVYSV
                     PIYKDNEVKGVIFATHSTKLYEKILSVPTFNGKGYSYITRSNGDIVLNPSSKNANSTK
                     ENLFSYIGRSDSISKSSINNMKSNIKNFKSGSLSYSMFGKGYYLSYAPIGINDWYLFS
                     EVPKTAISEKSYAIIKLTLSACVVLIIIFTALTIYILFIHKKSKEKLEEFAFKDNVTG
                     IGNSNKFNLEGGKFLSSHEKKNLVLIYFDIDKFKLVNDRFGYEEGDRVLKEIAEIIKN
                     IFKEQSVFSRISNDNFAIIFEKKNNRESIIEICELIRKKLSMIKTSLGVELNLIPSIG
                     VYFVEEGETNISTCLDKAMIAKTTVKRKYLKVYEIYAENLKETLIEERDIEQEMHDAL
                     KNEQFKVYLQPKVDLSTTKIVGAEALVRWQHPKKGLISPGVFIPIFEKNGFITELDMF
                     VFTQVCKNFKRWENENFPTFPISINLSRVHLENPGFISELERITKEYEIEPNLIEIEL
                     TESAIFDNTKILFKIMQTLKSVGFKISMDDFGSGYSSLNMLKDMPIDVLKLDRQFFIT
                     VGNAKKSQIVVSSIVQMAKQLDIKVVSEGVETVEQAEFLRFIGCDMAQGFLFARPMPI
                     EEYEKLILDRYSLNRKETN"
     gene            complement(32791..33888)
                     /gene="ychF"
                     /locus_tag="KR257_000317"
     CDS             complement(32791..33888)
                     /gene="ychF"
                     /locus_tag="KR257_000317"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416044.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="redox-regulated ATPase YchF"
                     /protein_id="HBH0029046.1"
                     /translation="MKLGIVGLPNVGKSTLFNAITQAGAESANYPFCTIDPNVGVVSV
                     PDERLNKLQELYNSEKIVPTAIEFCDIAGLVRGASKGEGLGNKFLSHIREVDAIVHVV
                     RCFEDENVVHVDGSVDPLRDIETINLELIFSDIEILERRINKTQKAAKADKTLGSELD
                     LLKSIMSTLEESKCVRTMEFTEDEQTFVNSLDLLTSKPVIYASNVSEDDLADNGENNK
                     YVQQVKAFAETEDAEVVVVCAQIEAEISELDSAEEKKEFLETLGLEQSGLDKLIKSSY
                     ALLGLISFLTAGPKEVRAWTIKVGSKAPQAGGKIHSDIERGFIRAETIAFNDLVEHGT
                     MAAAKEKGLVKLEGKEYIVKDGDVILFRFNV"
     gene            34204..35469
                     /locus_tag="KR257_000318"
     CDS             34204..35469
                     /locus_tag="KR257_000318"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454972.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="insulinase family protein"
                     /protein_id="HBH0029047.1"
                     /translation="MVNTKKIINLGNNINLTLIKTEKFKSNLISLYVQRLLDEKETTK
                     NALIPSIIASGSSKYPSARAISNKLDDLYGSSMGADAVKRGERQVLSFKVINISEKYL
                     DESIFEEVVEFFNEVINNTLVVDGGFKEEYLNIEKENLREKIQSIINDKKEYAQDKCI
                     EAMCKGERYSVSEFGYEDEIDSITSRELYEHYKNILKTSPIDIVVEGNFDEDKVVDII
                     SKNLKFEREEIINIPRADFIKNVDEVKVIDEQMEITQGKLVMGYRANVDYADIDKYYA
                     LVVGSNVLGGGPHSKLFVNVREKESLCYYIFSSIEKYKSIMFISSGIETKDYDKAVEL
                     IKKQVESVKAGDISDEELENSKLALVNSMKSITDNIGGMSDFVFSQSMAKTNSEVQDI
                     ISSIEKVTKKDIVEAIKNIELDTVYFLRN"
     gene            35484..36770
                     /locus_tag="KR257_000319"
     CDS             35484..36770
                     /locus_tag="KR257_000319"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728480.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="insulinase family protein"
                     /protein_id="HBH0029048.1"
                     /translation="MEKIVNDILKEEVYYEKLQNGLDVYFMPKRGFMKKYAILATNYG
                     SNDLEFVPIGEDKKIRVNEGIAHFLEHKMFEQPDGGDAFDKFSKLGVNANAFTNFTMT
                     AYLFSATENFYESLEHLIDYVQTPYFTDENVEKEKGIIAQEIKMYNDDPDWNVYFNCL
                     KAMYVNYPARIDIAGTVDSIYKITKEELYKCYNTFYNPGNMALFVVGDLDVEKVIDVT
                     KKSNNYKVDKLSKSIERFYPEEPEGVKEKEVIEKFPISMPMFNIGFKDSNVGLKGKEL
                     LRKEIVTDILVGMLFKKGSKLYEDLYMQGLINENFGAGFSSQVDYAFSIIAGDSKEPK
                     KVKEIILDYIEKSKKEGLSKEEFERTKKKKIGSFIKCFDSINFIGNSFISYVFKDINL
                     LEYLDVIKDITFEEVEERLKEHFKEEYCVISIVEPK"
     gene            37164..37910
                     /locus_tag="KR257_000320"
     CDS             37164..37910
                     /locus_tag="KR257_000320"
                     /EC_number="2.4.99.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890879.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="prolipoprotein diacylglyceryl transferase"
                     /protein_id="HBH0029049.1"
                     /translation="MDRVAFTLFGIDIMWYGILMACGMILGTLIAIKEAKRVGIKEDD
                     VLNIAIIAIPVGLICARIYYVVFNWSYYAQNMSQIFNFRGGGLAIHGGLIGGILAGYI
                     YTKIKNINFLKMADTVILGMPLAQAIGRWGNFINGEAHGGATNLPWGIMVDGVKVHPT
                     FLYESIWDFGIFIVLLLFRKNKKYEGQVIVTYITLYSIGRFFIEGLRTDSLMLGPLRM
                     AQVISLIGVIGGIIAHVYLSKKNKNNISEE"
     gene            37940..38875
                     /gene="rsmH"
                     /locus_tag="KR257_000321"
     CDS             37940..38875
                     /gene="rsmH"
                     /locus_tag="KR257_000321"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003427011.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="16S rRNA (cytosine(1402)-N(4))-methyltransferase
                     RsmH"
                     /protein_id="HBH0029050.1"
                     /translation="MEFHHVSVLLNECIENLNIKPDGVYVDCTMGGAGHSKEIVKKLS
                     DKGLFIGFDQDKNAISTAKERLSEYESRVKFVHSNFENIKEELEKIGVYKIDGVLADL
                     GVSSHQLDEADRGFSYMQDAPLDMRMDVRCEFSAYDVVNTYTEDELTKIIKDYGEDNW
                     AKRIAKFIVEERANKPIETTGELVDVIKKAIPKKARIDGPHPAKRTFQAIRIEVNNEL
                     GVITKMINDASSIMNEGGRICIITFHSLEDRIVKNAFKHLASDCICPQHLPICQCDKE
                     SEVKIITRKPILPSEEEIEVNPRSRSAKLRVAEKI"
     gene            39361..39708
                     /locus_tag="KR257_000322"
     CDS             39361..39708
                     /locus_tag="KR257_000322"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890875.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0029051.1"
                     /translation="MKKNYKIHNLNEYKNKKKNNYKKRNKKKIGAKCILLIATFSVII
                     LNLCGYSKISEMKYDIYYLQKDLRKKEIVLEELKAKETEKTSIKEIELKAKELLNMDY
                     PKDGQIKYIDVDN"
     gene            39720..41699
                     /locus_tag="KR257_000323"
     CDS             39720..41699
                     /locus_tag="KR257_000323"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416063.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="stage V sporulation protein D"
                     /protein_id="HBH0029052.1"
                     /translation="MRKVKRISKKRLVLVLILACALFFCLVIRTGYLQLMKGNWLSTK
                     ALEQQTRDIPIEPKRGTIYDRNMKELAVSVTKYTVWCKPVEVEDKKEAAEKVAEILDE
                     DYKDIYALISKKNMALVKVKRWIDDDKASQIRDAKLSGIWVAEDNQRYYPYGNFAPYV
                     LGHTSSDATGISGVEMQYDKKLKGKPGKLIVSTDASGREIPQGMEKYYEPVQGNGLVL
                     SIDEVIQHYTEKAVQKAYELNNAKKVTAIAMNPKTGDILALASKPDYDPNDSRTPIYP
                     YYQEELEKYNDKDKIKGYYQMWRNPAVSDTYEPGSTFKLITSSSALEEGVIKDGEKFT
                     CTGSVTVGGRKIKCWRHYRPHGTQEFKQAVQNSCNPVFVELGSRLGVGKMYDYIESFG
                     LMDKTGIDLPGEAKGILYNEKNVGPVELATISFGQSISVTPIQLITAISSIANGGDLM
                     QPRVVKSYTDNKGNITETVKPKKVRSVISKETSKKMLEIAESVVTEGGGKIAYIPGYR
                     LGGKTGTAQKVIDGKYAPGKYICSFVGIAPCDDPQIVVLAIVDEPTGVSAFGSTTAGP
                     IVKEIMNDSLKYLGVKPVYKEEEKAEYEKKQVKVPDVRNLKIGDAVKALEDAKLKPDL
                     DADIELPEDTKVKDIFPKPGVKVNEDSSITLYFEN"
     gene            41866..43239
                     /locus_tag="KR257_000324"
     CDS             41866..43239
                     /locus_tag="KR257_000324"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861626.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-
                     alanine ligase"
                     /protein_id="HBH0029053.1"
                     /translation="MECLTIKELVLATNGKLIYGDYNDCVSDIVIDSREANAQNAFVA
                     IVGENLDGHTFMKSAYDSGCKTFIKNESNGIKLESSDINLIEVKDTSLALGDISKYYK
                     EKFDIPFIGVTGSVGKTTTRDMIYSAISAKLNILKNEKNLNNHFGVPLTLFNLNKEHE
                     CAVIEMGMSGFNEIKYLVDIVNPKIAVISNIGLSHVEKLGSQEGILKAKMEITSNFDE
                     TNTLIVNGDDKFLSTLKEKEHVYKLKTFGFNKNNDVYCESYTMEEDSLTFICVINGKK
                     EEIFIPTIGEHNIYNAMSAILVGLCLNISLDYIKKGLKNFKGTKMRLDIIKNEKLTII
                     NDSYNASPDSMDAALKILGRYKGRRVAILGDILEMGEISEYGHRLVGKSSMNNTDIII
                     TIGENSVFIGEEAKQLGFNSANIYHFENREDVFNKLNELVKTGDTILVKGSRGMRLEK
                     IVEYLNK"
     gene            43280..44248
                     /locus_tag="KR257_000325"
     CDS             43280..44248
                     /locus_tag="KR257_000325"
                     /EC_number="2.7.8.13"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416067.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phospho-N-acetylmuramoyl-pentapeptide-
                     transferase"
                     /protein_id="HBH0029054.1"
                     /translation="MMLGITELTYTALIAFLIVIIIGPIFIPMLRKFKFGQTVRDDGP
                     QTHLAKNGTPTMGGIIMIVAILITGLTRVKVSHDMAVGLICIAGFGFIGFLDDFIKIK
                     LKRSLGLKAYQKIILQVALSFYVAFYQYTSSSSASQLMIPFTDFVINVGILYIPIMMF
                     IIVAIVNAVNLTDGLDGLASGVTLIVSVFFMLFASSIAGNTEVAVLAAATVGACLGFL
                     GFNSYPARVFMGDTGSMALGGAVVAFSVLTNSVLIIPIIGGIYFAEALSVLIQVGYFK
                     ATRKRFFKMAPIHHHFEQCGWPETRVVFIFWIITVVLAWISIIAVF"
     gene            44267..45622
                     /locus_tag="KR257_000326"
     CDS             44267..45622
                     /locus_tag="KR257_000326"
                     /EC_number="6.3.2.9"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454967.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-N-acetylmuramoyl-L-alanine--D-glutamate
                     ligase"
                     /protein_id="HBH0029055.1"
                     /translation="MDLKGKKVLLVGLAKTGISTIKHLDKLGASVIVNDIKDENKLRN
                     ILDELKSINDIKYILGHHPEDVDDIDMVVVSPGVPLDLPFILKLKNSGKYIIGEVELA
                     FKLSNNPIFIGITGTNGKTTTTSLVGEIFSRAKRDTYVVGNIGNPVIDTIETSSEESV
                     LVTELSSFQLESIDEFRPKVSAILNITEDHLNRHHTMEKYIEAKANIFMNQTVEDFCV
                     LNYDDEIVKSLADKCNAKVIYFSRTKKVNGGVYLENNDIIIDIDDKIKFLNKDDVSLP
                     GGHNLENCMAAIAIAYVCKIDLEVIKDVLMTFKGVEHRQEFVRNLDNVIYVNDSKGTN
                     PDSTIKAIQSYDRPIILIAGGMDKGSNFDELLETAKSYVKSLVLLGETASNIENCAKN
                     KGFNDIHIVKDMEEAVKTSYEISKSGDIVLLSPACASWDMYESFEVRGKDFKDNVNNL
                     K"
     gene            45674..46804
                     /gene="spoVE"
                     /locus_tag="KR257_000327"
     CDS             45674..46804
                     /gene="spoVE"
                     /locus_tag="KR257_000327"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426995.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="stage V sporulation protein E"
                     /protein_id="HBH0029056.1"
                     /translation="MPKENLKKQIDIRMKTEFDGVVFYTTMLLVFVGIVMVFSASFIQ
                     SSFKHNDAYYFLKKNVIYAVLGFIVMIITSRIDYSFWKKNATAIGAIAVVLLLLVLTP
                     LGIEANGAKRWLGIGALTFQPAEIAKFATIILTAKLIEKNYDKIKSLTKGVVPLLVVP
                     GIFFALIILQPNLSTAGTVILVTFVMIFVAGMDMKIVFAMIGSGAALFAALVIAEPYR
                     LSRVTSFLDPFQDPLGKGYQVIQGLYALGSGGLFGLGLGKSKQKYFYIPEPQNDFIFA
                     IIGEELGLIGCIIVIMLFVVLVYRCVRIALKTSNVFACMVVIGIGAQIGIQAALNIAV
                     ATSSMPATGVALPFISYGGTSLTIFMGAVGIVLNISKHVKIN"
     gene            46822..48048
                     /gene="murG"
                     /locus_tag="KR257_000328"
     CDS             46822..48048
                     /gene="murG"
                     /locus_tag="KR257_000328"
                     /EC_number="2.4.1.227"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893705.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="undecaprenyldiphospho-muramoylpentapeptide
                     beta-N-acetylglucosaminyltransferase"
                     /protein_id="HBH0029057.1"
                     /translation="MKVLLSGGGTGGHVYPAIAIANKIRDEHPDAEIIFVGTEKGIES
                     EIVPKYGFELKTVTVQGFKRKIDFDNVKRVFKLFKGLEQSRKIVKKFKPDIVIGTGGY
                     VSGPVLFNASMGKIPAIIHEQNSFPGVTNKILSKTVTKVLTSFEDSHKRFPEAAEDKL
                     VFTGNPVRKEILLSRKNIARKNLSISDEKRMVLCYGGSGGSRKINDAMRLVIKNMVNE
                     DIAFIFATGKSYYDEFMGSISDINLKPYQKVVPYLEDMANALAASDLVIGSAGAISLA
                     EITALGKPSIIIPKAYTAENHQEYNAKSIEKQGAGIAILEKNLTPESLNTAVFKLLGD
                     RELLVDMANASKTIGKPEAIDLIYDEIMKVYNSTQKSTSKKTKKEKVIKEVKEIKKET
                     TPSIEGQAKVIGIKKR"
     gene            48318..49058
                     /locus_tag="KR257_000329"
     CDS             48318..49058
                     /locus_tag="KR257_000329"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416077.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="FtsQ-type POTRA domain-containing protein"
                     /protein_id="HBH0029058.1"
                     /translation="MKKRRKLNTNNVMIVLVFILMLSFCICIIVKSDLFDVKKIDVIG
                     NKRVTKSNIMKELNVNLNENIFAYNFKDMKNKLIKNPYIENVEIKRKLPNKIIISLKE
                     KEIFAVLKDEDNYCYIDKKGNLLEELRGSNESKKDLIVDVDYSIDDNKSIKFKNYKTK
                     ENVFKTLNYLKEEGIYRKINYVNLKKESNIEMLTRSNIKILLSNDDNLDYNISRVSKI
                     LIDLQNKNTNGGTINLNYGKLAVYSPEG"
     gene            49081..49779
                     /locus_tag="KR257_000330"
     CDS             49081..49779
                     /locus_tag="KR257_000330"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416078.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF881 domain-containing protein"
                     /protein_id="HBH0029059.1"
                     /translation="MKKRFINKSIIIGSIVLGVLVSLQLKIINIENRGMTTFKRGEQL
                     TEELKSLKKEKENLQSEVNSVKKDIEIYRGKNNEGEQDILKSEIEKYETLAGYTDVEG
                     TGIKIEINSTKDLGNSDKNDSILYNYDLLLSMINKLNSAQASAISINDQRIVSNTYMY
                     LKEDKLYMNDTVIKEPIIIKAIGDSDTLASALNIKYGIVWEIETYYNAKVKVTKEDNI
                     EINGHSDINKAEGK"
     gene            49784..50458
                     /locus_tag="KR257_000331"
     CDS             49784..50458
                     /locus_tag="KR257_000331"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728479.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF881 domain-containing protein"
                     /protein_id="HBH0029060.1"
                     /translation="MKKKIVILGAFILGVFISTYIKSLDPNRVYITLGQTESIESEVE
                     NTKKEIKNLKETLKKNKKTLNEYKEAKKNGNESIQTLMQKELEEVKELSGYSTVTGPG
                     ITITMRDSERELKDGQNPNDLIIHDIDILRVLNDLKKAGARAISINGERVLATSKIKC
                     SGATITVNDTTYGQPFIIKAIGDIDLLSAAINSPESYAKSLKDIYGINIKVQENNGNK
                     VNLFAK"
     gene            50557..50910
                     /locus_tag="KR257_000332"
     CDS             50557..50910
                     /locus_tag="KR257_000332"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426985.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="small basic family protein"
                     /protein_id="HBH0029061.1"
                     /translation="MLWVLGGLAFGVVVGYYIPFTYSMDYSIYMSVAILAIMDSIFGA
                     IKSNFEDNYDNVIFITGFIGNAILAILLTYIGEKLGVSLYYVAVLVFGMRLFNNLSII
                     RRYIISNIMNKKRKN"
     gene            51100..52257
                     /gene="ftsZ"
                     /locus_tag="KR257_000333"
     CDS             51100..52257
                     /gene="ftsZ"
                     /locus_tag="KR257_000333"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009906025.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell division protein FtsZ"
                     /protein_id="HBH0029062.1"
                     /translation="MLNFDVELEECAQIKVIGVGGGGNNAVNRMVEAQLKGVEFISVN
                     TDKQALYTSKAEYKVQIGEKLTRGLGAGANPEVGKRAAEESKDEIVKLLQGADMVFVT
                     AGMGGGTGTGAAPVVAGLAKEMGILTVGVVTKPFAFEGKIRMKNAEGGIAELKSKVDT
                     LITIPNDRLLQIVQKNTSMLDAFAVADDVLKQGIQSISDLIAVEGLINLDFADVTTIM
                     KDKGLAHMGIGSASGETRAIDAARQAIQSPLLETSIQGAKGVLLNVTGGPNLGLFEVN
                     EASTLVMESCDPEANVIFGASIKEDLGDEIMITVIATGFEGLQNGALDLDTKPKSSIR
                     SSLNTTVKQAVKEIEEEVIAEEKIEPPKKASIIEEDDDESMEIPTFLRRRR"
     gene            52541..53815
                     /locus_tag="KR257_000334"
     CDS             52541..53815
                     /locus_tag="KR257_000334"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426980.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sugar ABC transporter substrate-binding protein"
                     /protein_id="HBH0029063.1"
                     /translation="MIKLKKVLSLVMVGILSVSILAGCSKKEDSKGKEGKEKLVVWSA
                     PLTDHDADAWKPIFEKFEKENNCEIEFQIVPWDNYAEKYATAISAGEGPDIGYMYAEM
                     FPQFIEMGAVEDLTPYLEKSGTSDNYLYLDDAKMMGGIYGLPIEAANPGVLYYNKDIL
                     EKLGEKPPKTWDDFKRICEKATKDTDGDGKIDQWGLAQGWGSKVFGSLNWNWYPYLWQ
                     AGGDIYNDDLKSVKFNNAEGLKAANFINDMKKYIPEDALSKDSNEMIESVFGPGKAAF
                     TIMLSSAATSTFDKSFPDLNWGYVTSLEDKTVGSFASVDDLTLMSACKNKELGFKLLE
                     YMLSKESMEAFHKEIPRAPVAKGEKYQGDPRFEEMVTRDKHMYRPLTVGPHGVEIYEY
                     LWKQLQMMIAGDITPEQALNESAKYANGLLAQ"
     gene            54105..54977
                     /locus_tag="KR257_000335"
     CDS             54105..54977
                     /locus_tag="KR257_000335"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012816317.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sigma-E processing peptidase SpoIIGA"
                     /protein_id="HBH0029064.1"
                     /translation="MFKGFKGGYMVYIEYYVIENLVINYIIISCTSILTKRYNPKKNK
                     LLGASLGGAYSVAYLYPSMNILFTVPFKIIIMSIITLISFRSKSKKDYVHVALVFYLV
                     NIFISGSTYFIIYFTGISHLKISFLIACTYVSCELLKYIYKDLKMLKYIKELTKTINI
                     NLLEKSFCCKALVDSGNLLKDPISQSDVIIVKSSVLEGFIPEKLLNINYEDIDMKKAQ
                     EIIGSLDDKTSGRVRIIPYKHAGSNKTSIIIGLKADYIEVDEQKIGNIILGISNFNDR
                     EYGAIMNPNILPGF"
     gene            55002..55724
                     /gene="sigE"
                     /locus_tag="KR257_000336"
     CDS             55002..55724
                     /gene="sigE"
                     /locus_tag="KR257_000336"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416098.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RNA polymerase sporulation sigma factor SigE"
                     /protein_id="HBH0029065.1"
                     /translation="MLRLKERIISFITMLGIKLKIIKPKGIYYMGGANILPPPLKPEE
                     EMELLQKLETDESVKSILIERNLRLVVYISRKFENTGIDVEDLISIGTIGLIKAVNTF
                     KLNKNIKLATYASRCIENEILMYLRKNNKKKTEVSFDEPLNIDLDGNELLLSDVLGTE
                     NDEIYKIIEEEIDRDLLVMALDRLSDREKQIMELRFGLIDKGIEKTQKEVAGMLGISQ
                     SYISRLEKKIISRLQKEMKKFV"
     gene            55816..56589
                     /gene="sigG"
                     /locus_tag="KR257_000337"
     CDS             55816..56589
                     /gene="sigG"
                     /locus_tag="KR257_000337"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011986856.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RNA polymerase sporulation sigma factor SigG"
                     /protein_id="HBH0029066.1"
                     /translation="MQVNKVEICGVNTSELPVLKNKQMKELLLQIKNGDEEARQQFVR
                     GNLRLVLSVIKKFNNRGENIDDLFQIGCIGLIKAIDNFDLSQNVRFSTYAVPMIIGEI
                     RRYLRDNNPIRVSRSLKDIAYKALQVRERLIRTNSKEPTVSEIAKELELEVESVVMAL
                     DAIQDPISLFDPVYQDNGDAIFVMDQVQDKKDTDENWLQEISLKEAIKKLNSREKLVL
                     DLRFYKGRTQIEVADEIGISQAQVSRIEKNALKNMRKYV"
     gene            56693..56956
                     /locus_tag="KR257_000338"
     CDS             56693..56956
                     /locus_tag="KR257_000338"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416105.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YlmC/YmxH family sporulation protein"
                     /protein_id="HBH0029067.1"
                     /translation="MIRVSDIMEKEIINVKNGKRMGFIIDIDMDIHEGKVVSFTIFGD
                     GSRSFFSRGGDEEVIFWNDILKIGCDTIIVNIGSELSLDEFEI"
     gene            56978..57439
                     /gene="nrdR"
                     /locus_tag="KR257_000339"
     CDS             56978..57439
                     /gene="nrdR"
                     /locus_tag="KR257_000339"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454958.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcriptional repressor NrdR"
                     /protein_id="HBH0029068.1"
                     /translation="MQCPYCNYKESKVIDSRHTDLKSIRRRRECESCKKRFTTYEKIE
                     TTPLMVIKKDNSREYFDREKIKYGLLKACEKRPVSIDEIESIVVHIENEINKCFIEEI
                     ETKKIGEMVMDKLKELDEVAYVRFASVYRQFKDINTFVNELKSILIEKGDK"
     gene            57436..58197
                     /gene="pgeF"
                     /locus_tag="KR257_000340"
     CDS             57436..58197
                     /gene="pgeF"
                     /locus_tag="KR257_000340"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416109.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptidoglycan editing factor PgeF"
                     /protein_id="HBH0029069.1"
                     /translation="MMKDYINIKNVQDIKEYVNLSGNCEELDEKLNSVNLVITCKNID
                     AKNREDMLKVCKECDLTFENLTSNSQIHSDIVNIVNKDTIGKRRDGDALITNLEKVPL
                     LLFTADCVPISIIDAKNKAIGLAHAGWRGTFSNIGHKTIKLMSECYKTVPEDLVCIIG
                     PSIGPCCYEVSEDLVEKFNTILTNNDEKFYIIKEGSYYLDLWKINEYMLRCSGVKKEN
                     IINLNLCTSCRADKFHSYRKHNKASERIGTVLQIK"
     gene            58212..58904
                     /locus_tag="KR257_000341"
     CDS             58212..58904
                     /locus_tag="KR257_000341"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416112.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HBH0029070.1"
                     /translation="MNTKVLVIDDEMHIVELLKFNLEVSNYEVSYSYDGFDGFIKAKE
                     IKPDLILLDWMLPNISGIEVLRKIRSDKDLKNIPVIMLTAKNMENDKVEGLEIGADDY
                     ITKPFSIKELLARISSVLRRYNLTSLGEENNILTTGNLKLDLSKHEVTKGSEKIELTL
                     KEFELLKLLIQNKGKVLSRNYLLDKIWGYEYYGETRTVDVHIRYLRKKIEDEDKSEKY
                     IETIRGVGYKID"
     gene            58933..60222
                     /locus_tag="KR257_000342"
     CDS             58933..60222
                     /locus_tag="KR257_000342"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422977.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding protein"
                     /protein_id="HBH0029071.1"
                     /translation="MEDLNSIYFFIVMLSIAIVILAVRYTITLRKYLKEFIYVSKKVS
                     NNEYHARLNISAKGELGELARNFNHMIKNMDKTLEEVQYKHLQLRSILKSISHGILAI
                     DVNGNILLINDEAKEMIKSEPNQLVEGHNINVVIKEEEILKQILQFIGSKDNETANIT
                     TKDDIVYKIKVDPVYLQNTNNVIIGSIVNIEDITKKVKLENMRSDFVANVSHELKTPL
                     TSISGFVETLKSNENIDVNTRNRFLEIIESESDRLKRLIDDILLLSFVENKDTLLMEN
                     VVVYDVFKEVYEITQHSASEKNIEVLYKCDDKSISILSNKDYIKQVFLNLVDNAIKYT
                     QDNGIVQVVVLKDEEKIVIKVIDNGVGIPKEDVERIFERFYRVDKARSRDVGGTGLGL
                     AITKHIVKSLNGCIKVKSELGIGSEFIVTILQKNFLK"
     gene            60277..61209
                     /locus_tag="KR257_000343"
     CDS             60277..61209
                     /locus_tag="KR257_000343"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454954.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YIEGIA family protein"
                     /protein_id="HBH0029072.1"
                     /translation="MEESLLNANLFRHSFIVALVVGILCRGLVLRVTDKQYPSRPQDY
                     LEQIIISGLSASLGAIALPALIDKEFAALTFFAVAIQQFQGLAEQERITLKNIDNEEL
                     VPKGDAYVEEIASTYESRSYISLFSALVSSIVYIVFARKYGLSFFYCTILAIVSGAIV
                     GLIFRRFLRRNSIADIADIVPAKISFEGPILMVNGVIITNIGLESTREKYRNECLAIE
                     VIPRDLGAFGIVNDIGQRQAIIHNLFIHMGIDRDVDEVDIVAISKTNLEKSTVVIPYM
                     PILKDIDVMIDVVKSTPIIETSKGKQSDFSRKTL"
     gene            61254..62186
                     /locus_tag="KR257_000344"
     CDS             61254..62186
                     /locus_tag="KR257_000344"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426964.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YIEGIA family protein"
                     /protein_id="HBH0029073.1"
                     /translation="MDRVFFVAVIIGITSRIIMLNLDQKQYPTQPNVLLSQLILAFVA
                     SSLGALLVPALINRSYTSITFLSLAAEQFRQVRANRRNTLQNLEEVQLVKRGAAFIEE
                     IARTYEVRNYMCIVTSFLTIGLYYVILAETKISEGMSLVISSICGLVLAFILKKLLTR
                     KSIGDIADVMPAEISFVDESILKVGDLKGITNIGLKSDREVYINRGVGIQIIPKNKDY
                     ANAGILFDSGQRQAIVYNIYSRLGLYGDYGEPSFVPLPRRNKEDESIMIAYLPVDKNV
                     EKVMEAVKSCPILSSSKGKNLSLKNYKIGKKGSA"
     gene            62188..62388
                     /locus_tag="KR257_000345"
     CDS             62188..62388
                     /locus_tag="KR257_000345"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454951.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0029074.1"
                     /translation="MGMDIGLNEYTLAIVTLDKNMKNGGGCPIFYANDEKDLQNKALL
                     MSKCVGGMVHDMTNGTLIIVKH"
     gene            62626..63954
                     /locus_tag="KR257_000346"
     CDS             62626..63954
                     /locus_tag="KR257_000346"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009906018.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF512 domain-containing protein"
                     /protein_id="HBH0029075.1"
                     /translation="MEVNVKKVNNIISKVYKDSIAEEIGIEVGDLLISVNEQPIHDII
                     EYRFLLSDEYLDVEIQKKDGEVYIYEIEKDYDEDLGVEFTNPIIDQAKSCRNKCMFCF
                     IDQLPEGMRETLYFKDDDSRLSFLQGNFVTLTNMSEEDINNIIKYRISPINISVHTTN
                     PELRQKMISNKFAGKLYGIMKRLADTHIEMNCQIVLCPGINDGKELDRTIKELAQLYP
                     YVNSVAIVPVGITKHRENLVELNIFNDKSASKTIEQIHQIQQKYLEKLGTRFAFLSDE
                     FYILSNSELPGYEEYEGFLQFEDGVGMIRKLKTEIEEYLNILPEKILKREKKVSIATG
                     HSAYEFIQSMADAMMDKFKNLQVNVYEIKNKFFGETITVSGLLTAKDLKEQLEDKELG
                     EALYITRSMLKADEEIFLDNIELNQLEELMRIKIIPCLNEGKDFVDKILK"
     gene            63988..65307
                     /gene="der"
                     /locus_tag="KR257_000347"
     CDS             63988..65307
                     /gene="der"
                     /locus_tag="KR257_000347"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012063975.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribosome biogenesis GTPase Der"
                     /protein_id="HBH0029076.1"
                     /translation="MSRPVVAVVGRPNVGKSTIFNKFAGKRISIVENTPGVTRDRIFA
                     EVEWLDKYFTLVDTGGIEPDSEDIILSQMRNQAMLAMDMSHVILFIVDGKAGITAADK
                     EIAQLLRKTKKPVILVVNKIDSQSQFDNIYDFYELGFGTPFAVSGANSMGFGDLLDEI
                     VENFPAGLDTEYEEDIIRVAITGKPNAGKSSILNKILGEERVIVSPIAGTTRDAIDTY
                     FEKNGQKFLLIDTAGLRRKSKIYETIEKYSVIRAMSAVDRADVVLIVIDALEGVTEQD
                     TKVAGIAHDEGKGCIFVINKWDLIEKDNKTMSNYTKDIKEKFPFMMYAPIVFVSAKTN
                     QRMNKILDTVEYVSNEHSKRISTSALNEVIGEAVMLNQPPSDKGRRLKIYYGTQTDIR
                     PPKITLFINDKDLTHFSYQRYLENKIRENFGFEGTSIKFEYRQKNKK"
     gene            65342..65956
                     /gene="plsY"
                     /locus_tag="KR257_000348"
     CDS             65342..65956
                     /gene="plsY"
                     /locus_tag="KR257_000348"
                     /EC_number="2.3.1.15"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426957.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycerol-3-phosphate 1-O-acyltransferase PlsY"
                     /protein_id="HBH0029077.1"
                     /translation="MEIFSYIIIAVVAYLLGNISTSYIVAKRIAGVDIRTQGSGNAGS
                     TNVLRTLGKRAGAMTFLGDVLKGVMAVLISEFAARLVGIDTLLAGYLAVICVVAGHNW
                     PAVLGFRGGKGVATSLGAMLAVNPVITLMCLAVFILVVAITKYVSLGSVVGIGCSPIF
                     MIMVKNKAGLIVALFLTASVIYNHRANIKRLLNGTERKIGQKKE"
     gene            65987..67006
                     /locus_tag="KR257_000349"
     CDS             65987..67006
                     /locus_tag="KR257_000349"
                     /EC_number="1.1.1.94"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009906016.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NAD(P)H-dependent glycerol-3-phosphate
                     dehydrogenase"
                     /protein_id="HBH0029078.1"
                     /translation="MEKVCVLGTGSWGSALALGLAKKGNDVSMWTRKEEQAKKINRTK
                     ENTDYLPGVLFPNNITISTDIEKTIKDCKVIVLAVPSQAVRSTCQKIKPFIKEGQVIV
                     NVAKGLEKGTGLRLSQVCEEELPQNPYVILSGPSHAEEVARDIPTTVVVASKDLKIAQ
                     MIQDLFMSPKLRVYTNPDIVGVELGGALKNIIAFGAGICDGLGYGDNAKAALMTRGIS
                     EMSRLGIAMGANMSTFAGLSGIGDLIVTCTSMHSRNRRAGILIGKGMSLEDTLKEVKM
                     VVEGITATEVAHDVAEKLDIDMPITNAIYSVIKKGSNPKEVGIELMMRSKKHEMEEVV
                     LGDDI"
     gene            complement(67163..67813)
                     /locus_tag="KR257_000350"
     CDS             complement(67163..67813)
                     /locus_tag="KR257_000350"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426952.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="HBH0029079.1"
                     /translation="MTNKELQKKRILMYFIEAAQNIMENEGIENITLRKVADMAGYNS
                     STLYKYFKNLDHLISFASIKYFKDYNLNISRCIENVNDEYKKYIIMWKLFCKHSFDNA
                     QAFYQVFFNLSSDELSYITKQYYDMFPEDLGIHDSDISLMITGESIKERNKILLNNLV
                     DTGYIPAKDLDIINDIIISFYQNLLFLKKNTGKNSDDDELTMKMISSIEYIIKHAK"
     gene            68132..69271
                     /locus_tag="KR257_000351"
     CDS             68132..69271
                     /locus_tag="KR257_000351"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454949.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aminopeptidase P family protein"
                     /protein_id="HBH0029080.1"
                     /translation="MSNNMRLERLRKYMNEKSIEIALIFEPDNQFYISGFKAITYSRP
                     IVTVVTQDKIELIVPGLEELHAKEVAKVDNVYVYYEIPEMKEHGISHKHYLDIILNKY
                     PKGTTVGIEKDIVSASFSEYITDKSFAIKDVGSKIFEMRYVKDAKEIEFLKIAGYLSD
                     IGIKGSLENVRVGMSELEFDVEGDNALLKYVSENYPDTYIGFANWTCSGIDRTAQPHL
                     DSNTRILQRGDIVIHSRQVWYENYRAENERTFIIGKPTERQKEVFKIAVEAQQAGLDT
                     IKAGIPARMVDEAARAVVAKYGLELYSNHRIGHGLGLSEHEEPYLRFDNELILEEGMV
                     FSMEPGIYIPGVGGFRHSDTAIVGKNGATIITNYPRSVEELILDI"
     gene            69323..70732
                     /locus_tag="KR257_000352"
     CDS             69323..70732
                     /locus_tag="KR257_000352"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890849.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amino acid permease"
                     /protein_id="HBH0029081.1"
                     /translation="MKKKIGFWDLVFMNISALFGIRWIAKSTASSFGLGLGSIPVWLL
                     FAFIFFVPASLICAELAATYPKDGGLGEWVKQAYGEKWGFMVSWLNWTSKIFWYSSFL
                     TFLAINIAYMLGNPDLSNNKMFILALSLIIFWLLSLVSTRGMAFGKFFTNTGALGSTI
                     PAILLIVMAFMSVVILKKAPSASIYTIQNIIPKIDANSLVSISAIIFALSGAETTANF
                     ITEMDNAKKNFPKAILTVAVLIGGIYILGSVAITMILPPDKIAASTGILDALAKVAQD
                     LGIGSWFIRIVAFGITLSVLGALILYIAGPVKMLFGNVREGVFPKQLTVTNKYNIPSN
                     AVIVQAIIVSLLLVGTNLLPSVDNIYNVLVTMTALTALFPYVLLFTSYIRLRKTRPNE
                     ERPYSIAKSDSVCINIARMVLVVTVVGILFSTAPVMETLKDNIIYEIEMIGGGLFVII
                     TGLMLWKNYEKKISNNSGR"
     gene            70916..72211
                     /locus_tag="KR257_000353"
     CDS             70916..72211
                     /locus_tag="KR257_000353"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903280.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MFS transporter"
                     /protein_id="HBH0029082.1"
                     /translation="MSVEVNKPSIWKNFKVLIILFVAGAFIYALPYLKNYYYDTFAQA
                     FNLTNTQMGSLGSIYGLLAMVSYLFGGFLADRISARKLLSGSLIITGISGLVLTLYPP
                     YIVVFLIHALWGITTILTFWPALVKAVRMLASENEQGKAFGFMESGRGITNAIHLSLV
                     LILFGYISSKVSDKSGLTAIIVLYSAINVIVGVLVFFKLKDNEKEVSAKFDKEAFFAV
                     IKMPHTWIITIIMFCSYSANMSFYYFTPYSTEAFGATVVFASAISILAQYCRPVASAA
                     SGLLGDKVGSSKIISYGFILMIAGLLGVIFTPTKSSMIYILLIGCVAIYVSMYAIQGL
                     HYSLLEEGNYSLSISGTAIGIVATLGYLPEVLCPLAAGKILDAFPGVTGYRYYFIVLT
                     IVAIIGLVFTFIWMNMTKERRKELIEMNNNSNENTTKVS"
     gene            72383..73858
                     /gene="spoIVA"
                     /locus_tag="KR257_000354"
     CDS             72383..73858
                     /gene="spoIVA"
                     /locus_tag="KR257_000354"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416145.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="stage IV sporulation protein A"
                     /protein_id="HBH0029083.1"
                     /translation="MNNNIYEDISKRTQGDIYIGVVGPVRTGKSTFIRKFMEKLVIPN
                     IDNEFKKDRTRDEIPQSGSGKTIMTVEPKFVPADGVEIKIKDTVSLKVRMVDCVGYIV
                     EGALGHEEGGKQRLVSTPWSQEAMTFEKAAEIGTKKVIKDHSTIGIVVLTDGSVTGID
                     RKSYVEPEERVIQELKNLKKPFAVVLNTLSPKSEETSMLRSELEEKYEVPVLPMNVVE
                     MEEEDIEEVMEAVLYDFPLTEIRINLPKWVEGLERNHWIKSSIITTLKQSIIDIGKIR
                     DIEGIIQGFSELEFLEDTGVDNVELGEGVINIDLQTKQDLFYNVLEEKSGFKIEGDYQ
                     LLSLITRLSKVKNEYDKIESALIDAKIKGYGVVAPSLEELSLEEPEIMKQGKQYGIKL
                     KANAPSLHIIKADISTEVSPIVGNQNQGEEMIKYLMEVFEEQPADLWESNMFGKSLHD
                     LVKEQLQSKLYTMPEEIRVKMQKTLQKIVNEGSSNIITILL"
     gene            74041..75996
                     /locus_tag="KR257_000355"
     CDS             74041..75996
                     /locus_tag="KR257_000355"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893688.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0029084.1"
                     /translation="MKKYEIFIFMSIIVLCFISFPHKVFGQEENCLEDFERWVQENKN
                     NKEEIVYTLSCDMVIDEEFRFYIPYDSNFTIDTNKYKILIKNHGRFIIDDNELNIIGE
                     GGKEGVIHIENGGSISIGINNIIATDGTALYVEEGGDLHIKSSYESVEKIKANGKDAI
                     GIYTENDIRILNKDIEVNGEHAIGVYSKGDVEIEETSIKAYSSNNESGLLRDNNKLAQ
                     SIISESKKVYIIDDYNELIPSIAEDSGYDIVKCCHRGIGVFSDEIKVSKDDKIENIKF
                     PKYMVLETSSGNRLDIDVEWDFTDYYEKLEKGENFNITGKFKTEMLNKEKIIINDDVV
                     PILNVSVIEKKPIDNLELEFQNTKNGYVAVLFYDMPYSASKVFVEYSSDGINWISEEQ
                     EDIRDQAILFFEDFKLRCFRVKVVGGLKEGYSNIVFKPGFIMGGGDNQETPDDEREND
                     DIDGDRGGGGRDDPDRDEDDNNQDGNNGNENNDSNNNQNNNNENNNNENDNSDEKQPN
                     TPKDDVESSTDSNENKNPHDIPKDGNKENNSDKEKGFYNKNSITENDDNYDLSSKSVF
                     GTNEHSFPYRESISNKNQDTNKNKSNISDYDGIINNNYKLESKEYNLKKDIIFLFCIL
                     TPIMIGSILIVNPDTRKSIIKFIKLKK"
     gene            76286..76555
                     /locus_tag="KR257_000356"
     CDS             76286..76555
                     /locus_tag="KR257_000356"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010963800.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ACT domain-containing protein"
                     /protein_id="HBH0029085.1"
                     /translation="MKAILTVIGKDKPGIVAGISDELYKQNINIVDISQKILQDYFTM
                     IMIVDLEKSLNSFEKTVEDLVERGKKLSVDVKIQREEIFNSMHNL"
     gene            76581..77936
                     /locus_tag="KR257_000357"
     CDS             76581..77936
                     /locus_tag="KR257_000357"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009170073.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PFL family protein"
                     /protein_id="HBH0029086.1"
                     /translation="MNVGNILETIKMIDEEQLDIRTITMGISLLDCIDPDGDKAREKI
                     YNKIMSSAKDLVKVGKDIEREFGIPIVNKRVSVTPISIIAGATDENDYVKFAQTLDKA
                     AEDLGIDFIGGFSALVQKGYTKGDKILIKSIPKALASTNKVCASVNVGSTRCGINMDA
                     VKEMGEIIKETAELTKDAKGFGCAKLVVFCNAVEDNPFMAGAFHGVGEADRIINVGVS
                     GPGVVKRALEKVKGEPFDVVSETVKKTAFKITRVGQLVAKEASSRLDVPFGIIDLSLA
                     PTPAIGDSVANILEEMGLEVVGTHGTTAALALLNDAVKKGGVMACSHVGGLSGAFIPV
                     SEDAGMIDAVIKGALSIDKLEAMTAICSVGLDMIAVPGNTTAGTLGAMIADEAAIGMI
                     NNKTTAVRIIPAPGCDVGDMVEFGGLLGRAPVMPINTNSSELFTQRGGRIPAPIHSFK
                     N"
     gene            complement(78399..79439)
                     /locus_tag="KR257_000358"
     CDS             complement(78399..79439)
                     /locus_tag="KR257_000358"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426938.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIC"
                     /protein_id="HBH0029087.1"
                     /translation="MSEILLGTGLLLLVLCCFTIFSYKAPYGMKAMGALANAACATFL
                     VEAFNLSLLGDVLGMEFFRSVGAANGSLGGVAAAILVPLALGVSPVYAVLIGLSCLDF
                     SILSGFVAGYFVSFLIKFIEKKVPPGVDLVVVILLCAPLSRLIASNVDPLVNSTLLQI
                     GQVLIEATNISPIIMGIILGGLITVVGTSPLSSMALTSIIGLTGLPMAIGALGAFGSA
                     FMNSTLFAKLKLGSKKDIISVAIEPLTQSDIISANPIPIYSTNFFGGAFSGIIVALMG
                     LVNMTPGTATPVAGFAIMFAYNPVQQVLITAGLCALFNVIAGFLGSKIFSTFKVLTAG
                     EIRGTDVEEEIA"
     gene            79820..80455
                     /locus_tag="KR257_000359"
     CDS             79820..80455
                     /locus_tag="KR257_000359"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897808.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0029088.1"
                     /translation="MKKVKYTRLVILGILIYLVFNILVMIISKNVDTLVLKNEKVDAK
                     IHVKGTIEKDANDQSNYLSTYISKEDSNNFEKNQNVIIEYHEQKLDAKVYKIYENNNK
                     IMVKLKISNQIVANQDTSVEEFDIIYNQMECLKIPKTSIKTKDNKRGVYVIDEQSQSV
                     KFVILEGITYENESSVFVDYYKNDINGVTSVNLYDKIILRPNSINTNIRIK"
     gene            80465..81169
                     /locus_tag="KR257_000360"
     CDS             80465..81169
                     /locus_tag="KR257_000360"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893687.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YggS family pyridoxal phosphate-dependent
                     enzyme"
                     /protein_id="HBH0029089.1"
                     /translation="MGSIKDNLSEIRNKIDKAAKKVDRDSKEITLLAVTKTVDVDLVN
                     EAMREGITSVGENKPQELARKYDIIGDKLNWHLIGTLQTNKVKYIIDKVCMIHSLDRI
                     ALCEEIQKRAEQINREIDCLVQVNISKEESKHGLDREEVVDFVKEVSEKYKNIKIKGL
                     MTMAPFIEDEDEIRGVFKGLKDLSKQIKELNIPNVGMDVLSMGMSHDYEIAIEEGATI
                     VRVGTSIFGERNYNKK"
     gene            81209..81667
                     /locus_tag="KR257_000361"
     CDS             81209..81667
                     /locus_tag="KR257_000361"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897807.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell division protein SepF"
                     /protein_id="HBH0029090.1"
                     /translation="MSNGIISKFKNWIVDEEEDYIEDEYESGMDDIVQEEEMNSGFST
                     AKANKIVNLHTTSQMKVVIVEPKVYDEAATIADHLKQRRAVIVNLEGLTNSEVRKSIF
                     NFMNGAVYVLDGSIQKVSKSIFILAPNNVDIDANMKKELESKAFFPWQNK"
     gene            81686..81943
                     /locus_tag="KR257_000362"
     CDS             81686..81943
                     /locus_tag="KR257_000362"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890838.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YggT family protein"
                     /protein_id="HBH0029091.1"
                     /translation="MGTIRIALYYLLDIIAWMIVIKSLMTWFPNGRQSKIFDILENLT
                     EPIEGPIRSIMYKYTNGPIDFSPLIAIVLLMFLRQLVLVIF"
     gene            81953..82738
                     /locus_tag="KR257_000363"
     CDS             81953..82738
                     /locus_tag="KR257_000363"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897805.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RNA-binding protein"
                     /protein_id="HBH0029092.1"
                     /translation="MDKLKLTNHIKDIDLKNKMFKVIDKANSCIKNYDVKSTEFLNPY
                     EVKNAVAILNSTNEIKYSVDGGYEQAERSTVFIYPFYMEYEDIEDTLRFLQIEGNFKF
                     KNISHKDYLGSILGLGIKREKIGDIIIHDSFCQVVVSSDICDFIIVNLEKVSRNNVIV
                     KEISRENIVNSSSKYKEVSFTVSSDRLDCVISGIYNISRQDSAKYINGEKVHVNYEKI
                     TSTSKIVKNDDLISIRGKGRAKVTQIGDITKKGKIKVQARLIV"
     gene            82773..83300
                     /locus_tag="KR257_000364"
     CDS             82773..83300
                     /locus_tag="KR257_000364"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416166.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DivIVA domain-containing protein"
                     /protein_id="HBH0029093.1"
                     /translation="MLTPIEIENKEFKKGLRGYRDEEVDEFLDIIKEDYESLCRENTA
                     LKEKLGLYQDQVNKYENIEETLKATLITAQSAAEDTCSAANKKAKIIVEEADLKARQI
                     IEQANNRVIEIRKEYDALVKEFKIFRNKFKSLLEDEIRSVDEIFYDVDEKCVNAFEGT
                     TVYNYSNDEAATTLE"
     misc_binding    83475..83707
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00230"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="T-box leader; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /bound_moiety="tRNA"
                     /db_xref="RFAM:RF00230"
     gene            83800..86907
                     /locus_tag="KR257_000365"
     CDS             83800..86907
                     /locus_tag="KR257_000365"
                     /EC_number="6.1.1.5"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728473.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="isoleucine--tRNA ligase"
                     /protein_id="HBH0029094.1"
                     /translation="MAKFKPLVDSSVKQAEAQVFDYWKDINILEKTLEKGKDDPSFVF
                     YEGPPTANGNPGVHHVLSRTLKDSVCRYKTMSGYQVKRKAGWDTHGLPVEIQVEKELG
                     LTSKQQIEEYGIAEFNQKCRESVFSFEKQWRIMTERMAYEVDLDNPYITLDNNYIESV
                     WWILNKFNKEGYIYEGHKILPYCPRCGTGLASHEVAQGYKEVKTNTVIAKFKKKDADE
                     YFLAWTTTPWTLPSNVSLTVNADVDYLKVKKGDEVYYVSKPLADKVLGEDYEVLEEMK
                     GKDLEGLEYEQLMPFVEVDKKAFFITVGDYVTTEDGTGIVHTAPAFGEDDYNTGKRYD
                     LPVIQPVDETGKFTSTPWEGRFVMEDGLDVEIIKWLASENKLYSKEKVVHNYPHCWRC
                     QTPLVYYAKPSWYIEMTKLKDKLIENNNGVKWFPSFVGEKRFGNWLENLNDWAISRTR
                     YWGTPLPIWRCECGHTDSVGSRAELAEKAIEDVNPETVELHRPYVDDIHLKCEKCGKP
                     MTRVTEVIDCWFDSGAMPFAQHHYPFENKENFDQLFPADYISEGIDQTRGWFYSLLAV
                     STFVLGKAPYKSVLVPDLVLDKDGKKMSKSRGNTVNPMELFDQYGADALRWYLLYVSP
                     PWTPTKFDMDGLKEIQSKFIGTMKNVYNFFTLYANTDDINPTEFFVEYKDRPELDRWI
                     LSKFNNLMKDVEENLAIFELNKTLRMIQDFINDDLSNWYIRRSRRRFWATELTEDKKA
                     VYNTTYELLHGLCRAIAPFAPYMSEEMYRNLTGEVSVHLAEYPKCNEELVDTKLEEKM
                     DLAKNLVTLGRASREVERIKVRQPLQKVLVDGKFEDTISDVVDLIKEELNVKEVIFAK
                     DLDEYMNFSLKPNFKEAGPLLGSKMNLFVGALSKLNAHETANKLEKGETLTVDLDGEA
                     FEFNKDLVLIGITAKEGFNVSVENNLFVILDTKLTEELINEGYAREFISKVQQLRKSN
                     NFEVLDNIVIEYCGDDEIAKAVDHFNEYIKSETLALEINRVDDKSLEEQNLNDHMTGI
                     KVIKK"
     gene            87194..88066
                     /locus_tag="KR257_000366"
     CDS             87194..88066
                     /locus_tag="KR257_000366"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426922.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YitT family protein"
                     /protein_id="HBH0029095.1"
                     /translation="MYGESKKLSIDNNIFLQYCLIILGMILSTLGINLYLAPAKLLSG
                     GVAGICVILYKLFGINQGISSFLMNIPIFIIARKYFDNKFLLISFVNMLLFSLALGLT
                     QDIAKYFPIDDTMLQCIYGGALTGIGMGLTFKARATAGGLDIIAAIMKRKYDIPMKNT
                     FLFINFFVVCAGAFLFGAKLVMYTLITMYIISFTMDIGKDCFDRKKSILLISNKYDEI
                     SKVIMNKMGRGVTFLEAEGAYTQNKKKMIYCIISANEIGKFKDLIYDMDSEAFISVNN
                     VEEVKGGGFKDKFL"
     gene            88193..88465
                     /locus_tag="KR257_000367"
     CDS             88193..88465
                     /locus_tag="KR257_000367"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009906007.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0029096.1"
                     /translation="MLRERFVVRNHHNPHTSGCCGTGGEGCCGGDNHEHSHQHSHSHG
                     HEHEHVNGVGHDHNHDDGFSGTHEHSHEHTHTHGHEHSDGHTHEHK"
     gene            complement(88628..89200)
                     /locus_tag="KR257_000368"
     CDS             complement(88628..89200)
                     /locus_tag="KR257_000368"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454936.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="HBH0029097.1"
                     /translation="MKTNNMKQAILSSATNLIAKNGVQNTSLADIAKDVNISKGTLYY
                     HYASKDDIIYDIADTHLEVITSAILNCVKNVKSKNSQIEMVNLILEKISTIESRGRVH
                     MYLICEAITSNNDLKERIRLKYIEWRTTLKSEIVESLEKYNSSENEQDAESFSFLLMS
                     IVDGLVVQSLLKTEKIPYENIASFLVNHWI"
     gene            89384..90226
                     /locus_tag="KR257_000369"
     CDS             89384..90226
                     /locus_tag="KR257_000369"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003431496.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DegV family protein"
                     /protein_id="HBH0029098.1"
                     /translation="MDKIKLIVDSACDLPDDIIEKYNIEVVGLNVSFGEESYISGKEI
                     DNETFYRKMSESKVLPKTSCPSPDKFLEAYHCQEESVLVINISSGLSGTYNSALLAKD
                     MFEKEGNNKKVEVIDSLSGSIGIGQLVLKAAILIKEGKEIEEIVSIINKYKDNPPFFG
                     TLETLENAIKGGRINPIAGKIINTLNFKAIIQVADGVVTPIDKARGEGNSLKKLITLV
                     ESKIKDKEEKVLFIGHANCPEKAQKVREVMEKDVKYKDVVICEVGSVMGTYTSKGAIL
                     ITAI"
     gene            complement(90343..91419)
                     /locus_tag="KR257_000370"
     CDS             complement(90343..91419)
                     /locus_tag="KR257_000370"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903275.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aminopeptidase P family protein"
                     /protein_id="HBH0029099.1"
                     /translation="MKAQRLNAVLEQMKKDDISQMLVSDPTSIFYLTGVLIHPGERLL
                     ALYLNLNGNNKLFINELFPVSEDLGVEMVWFNDTQNPVEIITEHIDKNATMGVDKNWP
                     ARFLLNLIELGGGSKFVNSSYIIDTLRMCKDEEEKELMRIASKLNDKAMEQLKATVSG
                     ELTEKQLVGKLSKIYEDLGTDGFSFDPIIGFGPNGANPHGEPGNALVKPGDAIILDIG
                     CIKDNYCADMTRTVFYKEIPEKGREIFEIVLEANKRAEAIVKPGVRFCDIDAAARDYI
                     TEKGYGQYFTHRTGHSIGLEVHDKGDVSSINTDTVQPGMIFSIEPGIYLPGEFGVRIE
                     DLVLVTEDGCEILNKHDKEICVVG"
     gene            91916..93319
                     /locus_tag="KR257_000371"
     CDS             91916..93319
                     /locus_tag="KR257_000371"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893682.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amino acid permease"
                     /protein_id="HBH0029100.1"
                     /translation="MEKKKIGLWSLVFMNVSALYGIRWIAKSTASSFGLGLGAIPMWL
                     LFSFIYFVPGALICAELASTYQKGDGGLYDWVKEAFGEKYGFLVSWLNWTAKIFWYSS
                     FLTFLAVNVSYTIGNPALADNKMFVLILSLIIFWALSLIATKGISFTKIFTNTGALGS
                     TIPSAILIIFSFVAVFVLKKHDIASTYTIASMTPKLNMDAFVAISAIMFGLAGAETAA
                     NFITEIDKPEKNFPKAILISAGIVASLYVLGSIAITMIIPPDQITASKGVLDALSAVC
                     ASLGIGSWLVQLIAFGIAFSVLGAIVLYIASPIKMLFGSVKKGIFPDSLVEVNEHKIP
                     SKAVILQAIIVTIILLVTTLMPSVDAIYNVLVTMTALTALFPYVLLYASYIKLRKERP
                     DEIRPYTMAKSTSTCLGLAKMVLVVTVVGILLSAAPVMPTFAENVIYEIEMIGGGLLV
                     ILSGLWLWNRYEKKTAK"
     misc_binding    93410..93650
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00230"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="T-box leader; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /bound_moiety="tRNA"
                     /db_xref="RFAM:RF00230"
     gene            93693..94391
                     /locus_tag="KR257_000372"
     CDS             93693..94391
                     /locus_tag="KR257_000372"
                     /EC_number="3.2.2.9"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890826.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="5'-methylthioadenosine/adenosylhomocysteine
                     nucleosidase"
                     /protein_id="HBH0029101.1"
                     /translation="MNVIGIIGAMDEEVSILVDLMDIRETIKKASLEFYKGILEGKNV
                     VLVKCGIGKVNSALCAQILISEFKVDAIVNTGVAGALNEKLDVNDIVISTDAIQYDVD
                     TTAFGDPKGVIPRMKTSVFKADERLIDAAYKSSVEEVKTHKVLKGRVVTGDKFINSKE
                     LKEELVNDFGGYCGEMEGGAIAHVCYLNNTPFVIIRAMSDKADGSADVTYDVFVHDAA
                     NNSKDIVLNMLKSI"
     gene            94414..95415
                     /gene="trpS"
                     /locus_tag="KR257_000373"
     CDS             94414..95415
                     /gene="trpS"
                     /locus_tag="KR257_000373"
                     /EC_number="6.1.1.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729405.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tryptophan--tRNA ligase"
                     /protein_id="HBH0029102.1"
                     /translation="MSEKKVILSGAQPSGKMTLGNYLGAIKNWTELQDNYDCYYSIVD
                     LHAITVPQDPKVLRANTIELLAQYIACGLDPEKNTIFIQSHVKEHVELMWVLNTMTYM
                     GELSRMTQFKDKSQKSEANLNAGLFTYPVLMAADILLYQTDLVPVGDDQKQHLELARD
                     LANRFNNRFSPTFVVPEGYYPKGGARVMSLQEPTKKMSKSDSNENAFILLADDSDSIK
                     RKIKRSVTDSLGVVKYNDEQPGIKNLIDIYSNLSKKSVEEIVNMYEGKGYGIFKEDVA
                     EVVSEALRPIREKYVDLLNNKDYLEKIYSMGAEKAEKQARKTLRKVYKKVGFIERRY"
     gene            complement(96067..97634)
                     /locus_tag="KR257_000374"
                     /pseudo
     CDS             complement(96067..97634)
                     /locus_tag="KR257_000374"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_021426623.1"
                     /note="frameshifted; internal stop; incomplete; partial in
                     the middle of a contig; missing N-terminus; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="iota toxin protein Ib"
     gene            complement(97970..98152)
                     /locus_tag="KR257_000375"
     CDS             complement(97970..98152)
                     /locus_tag="KR257_000375"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454925.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0029103.1"
                     /translation="MKKFRKHKSISNCISILLILYLTLGSLLPNNIYAQDLQSYSGKV
                     CNTTYKAPIERSEGFF"
BASE COUNT        38062 a        11256 c        16955 g        32282 t
ORIGIN      
        1 tttattaaaa atctatactt aactaataaa gcttcaataa cttatttaca ataaatacta
       61 aatcataaaa tatttgttat tttttattat taccaagtat aaaaaatatt ataattgtaa
      121 aacttacaaa tatatgtaaa atatttagga gtgatgaaaa tgttaaatgg gataataaag
      181 cttttttatt ctgaaattgt aaaaacaaag attaataact tagattcaag tggatattct
      241 ttaagagatg aatgtaaaga aatcagaaat ataactctaa agatagatag tgtatttttt
      301 aagcttttaa agttagcttt tggttcaata ttgcttatgg tagcttttaa tttaaacatg
      361 gttttaggta taggagtgtt tttagttggt gtagtttata tactatataa aagaaatatg
      421 gaagaacaag taaaagagca tataaataat gtgaaaaata atatcgacat ctctaaaata
      481 acttttatgg atgaaaaagg gagaacaggt ctaaatgcat taattacatt acttcttata
      541 ggattattga caggatttaa ctggatatta gttgctagtt ttgtcgttgt ttttgttttt
      601 actataaaga atgtatgtta aaatactaat aaatagttta atatataggg ggagaaattg
      661 agtatgacta atggcagtta taaaatgaag aatttagtgg aaatatccgc tatggtgact
      721 gaatctacag atttttttaa tataaaagat gacataatag aaaaaatgtt agaagttgtt
      781 caccctacaa aggcatgtgt gaatctattt tataaaaatg attctaaata tgcctactta
      841 gtatgttcgc aaaccttaga atatgtacct caaatttttc caataaatag tcttaaaggt
      901 gcaaaaattg attttgacac atatccagag tatatacatg aggctgtaaa tgaaaaaaaa
      961 ataatatatg tggaaaatgt atttgaagat tctagagcag aaggtgaacg agatttagca
     1021 aaagctgaag gttatattgg gagaatagtt tttcctttta taataaataa cgtagttgtt
     1081 ggatttatga cttgtttttt aaaagaggat gattatataa cagaacaaga tatagatttt
     1141 atatcatctg ttgcatcact cttaagttta tcaatagaaa taactaataa aaataataat
     1201 gtacaaattt taattgataa actaagaggc tcaataagtg ccataaatga agctactaaa
     1261 aaactatacc ttaataagag tattgatgga tttttggaaa atttaagtaa acaagcgtgt
     1321 aatattacta atagtaaaga agctttaata attataaata gtcatcataa taaggatgct
     1381 atagttagtt gttataatgt tgagcaaaaa aagaaaacaa atttatatcc tatgattgat
     1441 atgtttttaa agaaagagtc attggggggg tatttaaata atttaaaacc atgctcaaaa
     1501 aagggaataa atttggaaag ttatatatat tacaaacttc aggataaaaa tgagactata
     1561 ggatgtatag tttgtgcaaa tagcaaaaac tatactagtg atgatttaaa tattcttagt
     1621 atattgtcca aacaagtttc tgttggtatg caattatatg aacataatga aaaggaagta
     1681 aaacacaaag ttcttgaaaa cgagttgaac atattaaata aacaacaaca gcttattatg
     1741 gataaaggta aaatggattg taatgatgag aaagaacttt atttttacca taaaccagca
     1801 agggtagtag gtggagattt ttattatgct acaaaagtgg atgatgaaca tatagtttat
     1861 attgttgctg atgtaatggg acatggaatg gtatcaaatt atgttgttgc aatgataaaa
     1921 ggtgctttta aagtattatg caatcaatac aatacaccaa gagaaataat gacaaattta
     1981 aataggatgt tatatgatga atttgacaag atgggagtat ttacaacttg tttgataggt
     2041 attatagata ctaaagaaaa tatgattact gtgtctaatg caggtcacta tagtcctgta
     2101 gttgtaaaga aagatggcac aatagaaaat aatttaaatt gtaaaaaggg catacctatt
     2161 ggaataatgg aagatgctac ttatgaaaat aatactcttt caatggaaga ttatgcaatg
     2221 gtatgtatgt acactgatgg aattttagag ataaaaaatt catcaaaaga agagtatggt
     2281 ataaacagat tagaaaactt tctaaaagaa aattttagat taaatcaaca gttaatagta
     2341 gaaaatctaa aattggattt aaagaacttc tcatcaaaag ataattatga tgatgatatt
     2401 ttaatagtta tgttaaagga taggtagatt gattatggat tcaaacgata aaaaaggact
     2461 taaaagtcca gagattataa taataaatgg aagtccaaga attaataaaa attgcagttt
     2521 tatagcaaat gaagtaaaag ctatgctaga agagtgtgga ttaagttgta aaatatttaa
     2581 tatctacaat atggatattg aatattgcac agcatgtgga ttttgtgaaa aaacagggta
     2641 ttgcaagttt aatgatgata tgaagccatt atataaaatg tttgatgatt caaaaggaac
     2701 tatagtaata agtcctgtac attttgattc aatatcagct aaattaaaga ctgttgttga
     2761 tagaactcaa gctatatatg caagtaaata tgtattaaat aaaccttcaa ttgatagaag
     2821 taagaaacgg ataggaatgt atattgcagt gggagggagt aaatcatatg attcacagtt
     2881 taaaggtgga cagattgtta tggatttttt ctttaagagt ataaatacta aacttttaca
     2941 caatatatat ttaaacaata cagatgatgt atcttatata gataatcaag aatttaaaga
     3001 tataatatat aaaaatttaa agatatatat tgattcaata taatttgatt ttgtaggtaa
     3061 tattatgtat aattgtattg caataattta aataattaaa aggagggaat ttcaatgaaa
     3121 ttaccaatag cattatctaa taaacatgtt catttgagtc aagctgatat agacgtatta
     3181 tttggagcag gtcatgagtt aactaaattt aaaccattat ctcaaccagg gcaatatgcc
     3241 tgtgaagaaa aagtggattt agtaggacca aaaggaactt taaaaggagt tagagtacta
     3301 ggaccagcta gagctcatac tcaagttgaa atatctttag cagatggttt cccattagga
     3361 gtaaaagcac caataaaaga atctggtgat atagctggaa ctccaggtgt taaattagta
     3421 ggacctgctg gagaagttga aatgaaagaa ggagttatag ttgcttctag acatatacat
     3481 atgagcaatg aagatgctgc taaatttggt gtaactgata agcaaatagt aaaagttaaa
     3541 acatctggac caagagcatt agtatttgaa aatgtattag taagagctag tgacagcttt
     3601 aatctagaaa tgcatgttga tatggaagag ggaaatgcag caggcgttaa aaatggagat
     3661 ttagtagaat taatagttga ttaatattat aaatagactt tatgctagta gatattttat
     3721 ttgctagcat atttttaaat gtaataaatt tctataggat aaatttaatc aattagatta
     3781 atttataaaa taaaggggta ttataaaaaa tgtaataaaa acttacaaaa atatgatgta
     3841 atatggtaaa attatatata taaaaattta catgtaataa ggataagcat tttacttttt
     3901 atactaatat gaacaaatag ataaaaaagt ttgaaaaatc taacttaatt tattatatat
     3961 tgtatacaaa attatgaaaa aaacttaaca tatttaattt taaaaaaaat ctacttaaat
     4021 atgtaattaa tttacaattt tcaaaggaat tttatctaat ctgtagtatt atattagaag
     4081 atagagtatt tgcgcgacta tatgtgtgtt tatagttttg ttgtgtaaat tatatgtaaa
     4141 tataaaaaaa tagacttgtt ataaacaagt acaattgtag ctatcaagga ggatacatat
     4201 tatggctaag tttatgaaaa cacttgatgg aaatacagct gcagctcatg ttgcctatgc
     4261 gtttacagat gtagcagcta tatatccaat cacaccatct tcaactatgg ctgaagtagt
     4321 tgatgagtgg gcatcacaag gaagaaaaaa tatatttgga caaacagtta atgttgttga
     4381 aatgcagtca gaagcaggtg catcaggaac attccacggt tctttacaag gaggagcttt
     4441 aacttctact tttacagcat ctcaaggttt attattaatg atacctaaca tgtataaagt
     4501 tgcaggagag ttgttaccag gagtattcca tgtaagtgct cgtgctttag catctcaagc
     4561 tttatcaata tttggggatc accaagacgt tatggctgct agacaaactg gatgtgtatt
     4621 attagcttct ggttcagttc aagaagtagc tgatatagca cctgttgcac atttagctgc
     4681 aatagaaggt agattaccat ttatacattt ctttgatgga ttcagaactt cacatgaaat
     4741 ccaaaaagtt gaattactag aaaatgaaga ttatgcaagt ttattaaact ttgaagcagt
     4801 tcaagcattt agagataatg ctttatctcc aaatcatcca gttgctcgtg gtactgctca
     4861 aaacccagat atatatttcc aaactagaga agcttctaat aaatactatc aaaatatagt
     4921 aggtatagtt gaaaaataca tggaaaaaat gagtaattta acaggtagaa aacatagttt
     4981 atttgattac tatggagcag aagatgctaa atacgtatta atagctatgg gttcagtaac
     5041 agaaacaata gaagaaacta tagattactt aaatgctaag ggagaaaaat atggtttagt
     5101 taaagttcat ttatatagac cattctcaat gaaacatttc ttagatgcta tgccatctac
     5161 tgttgaaaga atatgtgtac ttgatagaac taaagagcca ggttcaactg gtgaaccatt
     5221 atacttagat gtacgtgatg tattctatgg aaaagaaaat gctcctatga taataggtgg
     5281 aagatacgga ttaggttcaa aagatactac tccttcagat ataaaaactg tttttgataa
     5341 cttagtttca gaacaaccta aaaatggatt tacagtaggt atagttgatg atgtaactaa
     5401 tacttcttta actccatctg agccaataaa aatagcttct aaaggaacta taagatgtaa
     5461 gttctgggga ttaggttctg acggtactgt tggagctaat aaacaagcta tcaaaataat
     5521 cggtgaccat actgaaaaat atgctcaagc ttactttgat tatgactcta aaaaatctgg
     5581 tggtataact atgtctcact taagatttgg tgatactcca ataagagcta cttatttaat
     5641 agatgaagct gattatattg cctgtcataa acaatcatat gtttatcaat atgatttatt
     5701 aaaaggtctt aaaaaaggtg gtacatttgt acttaacact atatgggacc aagcaggact
     5761 tgaagaacat ttaccagctc atatgaaaca atatatagct aaaaatgata taaaattcta
     5821 tacagttaac gctgttaaac taggacaaga aataggtctt ggaaacagaa taaacatgat
     5881 aatgcaatct gcattcttta aattagctga aataatacca gaagaagatg ctgttaaata
     5941 cttaaaagat tctatagtta aagcttatgg taaaaaaggt gaaaaaatag ttaacatgaa
     6001 ctatgctgct gttgatgcag gaataaatgc tttagttaaa gttgaagttc cagcttcttg
     6061 ggaaaatgct gttgatgcag ataaaggaga agttaaagaa ccagaattta taaaaaatat
     6121 actaagacca atgactgcac aagaaggaaa caacttacca gtaagtacat tcaatggtat
     6181 agaagatgga acattccctt gtggtactgc agcttatgaa aaacgtggta tagctgttga
     6241 tgttcctgaa tggataatag ataactgtat tcaatgtaac caatgttctt ttatatgtcc
     6301 tcattcatgt ataagaccag tattagttac tgaagaagaa ttagctaatg ctccagaagg
     6361 atttgaagct aaaaaagcat taggtaaagg attagaagga ttaaaatata gaatgcaact
     6421 tagtccactt gactgtacag gatgtggaaa ctgtgctgac atatgtccag ctaaagaaaa
     6481 agctttagtt atgaagccaa tagatactca acttgataca gagttagata attgggcatt
     6541 tgcagtaaat cctgatgagg tagctccaaa aggtgatgtt atgcctgcaa acactgttaa
     6601 aggaagtcaa tttagacaac cattaatgga gttttcagga gcatgtgctg gatgtggaga
     6661 aactgcatac attaaagtag ttacacaatt atatggagat agaatgatga tagctaatgc
     6721 tactggatgt tcttctatat ggggagcttc tgcaccatca attccttata cttgtaacca
     6781 tgaaggtaaa ggtccatctt gggcaaactc tttattcgag gataatgctg aatatggatt
     6841 tggtatgtac acagctgtta agcaaataag aaataaaata gtagatgcta tgacagagtt
     6901 agtttctatg gatatctgtg aagatgctaa agcggtattt acagagtggt tagattctag
     6961 aaatgatgga gaagcttcta aagtagcaag tgctaaggtt gttgaattat tagaaaaacc
     7021 agcttgtgat tgtacagatg aaaaagctaa agagttagta aaagctataa aagatagaaa
     7081 agattatcta gttaagagat ctcaatggat actaggtgga gacggttggg catatgatat
     7141 cggttacggt ggattagacc atgttcttgc atctggtgaa gatgtaaacg tacttgtatt
     7201 tgatacagaa gtatattcaa atacaggagg tcaagcttct aaagctactc cagctgctgc
     7261 tatggctaag tttgctgctt caggtaaaaa atctagaaag aaagatttag gaatgatggc
     7321 tatgacatat ggaaacgtat atgtagctca agttgctatg ggtgctgata aaaaccaatt
     7381 tatcaaagcc gttatagaag ctgaaaaaca tgatgggcca tctttaataa tagcttatgc
     7441 tccatgtata aaccatggat taaaagaagg tatgggaaga actgtagcta acgaagcaca
     7501 agctgttgct tgcggatact ggcatttata cagattcaat ccagaagtaa aagctgaagg
     7561 taaaaaccca ttcactttag attcaaaaga accaactgca agcttcaaag atttcatact
     7621 tgcacaagta agatattctg ctatagctaa acaattccca gaggaagctg atggattatt
     7681 tgctaaagct gaagctgatg ctaaagaaag atatgaagga tacaaaaaat tagctgaata
     7741 atattaaagt attataatgc ttatatagaa ttgataaaag agagtgtctc aaagtgagct
     7801 ttttagttca tgaggcactc tttttgtatg aaatcaaata tattttaatc atttcaacaa
     7861 tgaaaaaggc cttatctcta ttttgagaca gccttttttt atgaagatat taagatcctg
     7921 tttttaccta ttaaatatct ttttaagttt tccattttca tcttgccaat actttttata
     7981 tattgctcta cacactaaaa ttaagagaac aaataatatt tatagtatgt atatttggat
     8041 ttgataattt taaaatagat acaaaagagt atctcatttg tgttttttat cacttagaga
     8101 taatcttttg atatgtatgg aaaaagatta ttttatccta caaagatttg tgtccaataa
     8161 attgaaccac cacttttttg tgctactcca acacctattt tactgaaatt tggattcatt
     8221 atattttttc tgtgaccttc agaattcatc catgcattta caacttcttt aggagttttt
     8281 tgacccatag ctatattttc acctgctgtc ttatagctta ttccaaattt tttcaacatg
     8341 tcaaatggag aaccataagt tggagaattg tgtgaaaaat agttgttatc aatcatatct
     8401 tgagattttt ttgtagcaac atttgatata gaagaatcaa gagtaagagg atttaatcca
     8461 gctttagctc tttctatatt tactaagtca acaacttctt tttggtaagc tgaaaaactt
     8521 tcacttgtag agcctgagtt gttattatca tcaggtttgt tagtagagtc tgaattattg
     8581 ttgtcttcag gtttatcagt agagcctgaa ttattgttgt cttcaggttt attagactca
     8641 ggtttattat tatcaggttt attagtagag cctgaattat tgttgtcttc aggtttatta
     8701 gactcaggtt tattgttacc aggcttatta gtagagtctg aattattgtt gtcctcaggt
     8761 ttattagtgt tgttgcaatt cttgtcatta tgattcttat ccttacaaga gttatcttta
     8821 tcaggcttaa gttctggttt tacagaacaa tttggttttg cagaaaactt gtatttagta
     8881 ttactatata ctaaactttt gttacttata tttacattat tttcaagtga tgaagcactt
     8941 gcagtaacag cacttgaagc tgttgctaaa gttaacactc ctaaagctaa tatagttttt
     9001 aattttgttg gtatatttct tctcatcatt aaacacctct taatctaaaa attctaaaaa
     9061 tgttactgat ttgtaacctt tagtgtaggg ggttacccgt gaatctatac taacataaga
     9121 ttaagacttt ttttactgta aagatatgta aaaaagatat atatggaata aataggtata
     9181 tttcagtgtg tttgacaatt tgtattaaaa gcctgtatag tatggaatta cttagttaga
     9241 gaaaataata tttttataat aattccataa cgtaaattta tagttatgat aaattttttt
     9301 ttatttggtt aaatttattc agtagatgct ttcgtattag caacaaatta taattattta
     9361 aatctttaag aaataaaaag ggtctgtctc aaaatagaga taaggccttt tttattgttt
     9421 aaatgatagg catatgttat ttcatataaa aagagtgtct cattaagtaa aaagttcact
     9481 ttgagacacc acctttcata ttatgaattt taatttgttt tatattaata cattagtaat
     9541 cctaatgtaa ttacaataat ttctgctatt agtgaaccaa ctgcaactac aatgaaagtt
     9601 tctttaaatc cagttttatg tgttaactta gataagctta agaatgtaag aaaaacacca
     9661 ctttgtggaa ctatagttag tatatttgaa gctattgtag caacacggtg aattaattct
     9721 ggatttagac cagtacttaa ataataatct gcaaagtttg gcattactat tcctaatgca
     9781 ccagaagagg accctgttat tgctgacatt gttgaagtca aaacagtaag acttataagt
     9841 ggactacctg gtattgacat tataagtttg ctaaatacat caaaaccagg tgcagccatt
     9901 attactgctc caaatgcaac tgcagaagat gtagcaaata taggacctat agaaccacta
     9961 gcacctatgc tcaatgtctg tatcttagat gatagaaatt tatggaataa aaaagcagat
    10021 aaaagaattg caactattaa agctatgtaa attacatttt ttttcataaa ttctgaacca
    10081 aaagtacttc cagttatagc tataattacg agtgctaata gaggaaaaat acttgcaaaa
    10141 aatcctggta attctctatc taaagattct tcttctaatt ctgaagtata agttgcataa
    10201 gtttcacctt ttctaatact tttgtttaga gcatatttca tatagacaag tccaaacgta
    10261 gcacaaccta tactacctac aatacttggt atagtagctg cagtaagaga cgtatttaga
    10321 tattgaatag gtataacatt ttgaatggct ggtgttccag gaattatagt catagtaatt
    10381 gttgcaatac caagccaaag tggtatctga ataaggttcc aagaaatatc aagtttttta
    10441 aatagagttc ttgcaagtgg aatgaccgca aacataacta caaataagct tataccacca
    10501 tacgttaata taaaacttac tataaatata gcaactaaaa ctctataagg atgattagag
    10561 ccaaatttat ttaaaataaa atcagctatt gatacagtag ctccactttc ttccataaat
    10621 ttagcaagta ttgagcctaa taagaatatt gcaaaataac tcattatata gtttccaagt
    10681 gcacccatat aattgttttt gtcagcacct agcattgatg ttacaacatc cattttattt
    10741 aaaataacaa ctattaaagt tgctattgga gcagctatag ttatatgaat ttctttaact
    10801 gaaaaatata taatagctat gataccaata attataccaa ttggtgcgat aatactcata
    10861 aatatccctc cttagtagaa ggacctgaag aatactttct tcaagcccta aatataataa
    10921 ctattgtgca gtatatcctc catctagtaa gcaagcttgt cctgtaatac ccttagcatt
    10981 atcacttgct aagaacatag catagtcggc aatttcttga acatctaata ggcgtttttg
    11041 tggtacaagt gggtataaaa cttcctctaa gacattttcc aatggtatat tacgagtttt
    11101 tgaaaggtca ttgaactgac ctctgacaag tggagtatct acatatccag ggcataaagc
    11161 attaactgtt ataccagaat cggcagcttc aagagcagca acttttgtta gtccaataag
    11221 tccatgtttt gctgagttat aagcagcctt tccagcaaat cctattacac cattgattga
    11281 ggccatattt attatacgac caaagccttg ttttttcatt ataggaaatg cttttttagt
    11341 agctataaaa ggtgctgtca gcattatttt tatcataaat tcaaatttat cagttgggaa
    11401 atcttctatc atagaaacat gttgaagtcc agcattgttt attaatatat ctaatctgcc
    11461 atacttttca acagttttgt ctatagcgtg gttaatttct tcttccttag ttacatcaca
    11521 ctttacactc atgcaatcat aacctttttt ttgtaactct gttatggtat tatttaaagc
    11581 ttcttgattt atatcagaga acattacttt agcaccattt tttaagaacg attcagctat
    11641 ttgtttacct attccacttg cagctcctgt tacgaataca actttatctt taaccatttt
    11701 catttcctcc aattttattt tatttttata ttaatatttt aagcaataca aatttatatg
    11761 taatacgtct aagagatttt tattttctag ttttaattat tttaaacaac agatattttt
    11821 ccatttaatg aatctgacaa tattaaagga gcctcagtag cagaaataac atcatctaat
    11881 gtgaaagctg gatttatttc tttaagtaaa attccatctg atgttacttc cataactccc
    11941 atttcagtaa ctatcaaatc tacagcattt gttgcagtaa gtggaagagt acaattattt
    12001 aatatttttg cagaaccttt tgaagtatgt tccattgcta caataacttt tttagctcca
    12061 gttactaggt ccatagctcc acccatacct ggaaccatct tacctggaat catatagttt
    12121 gctatattac catatttgtc aacctgaagt gcgccaagaa cagttatatc aacatgacct
    12181 cctctgatta ttccaaaaga agtagcacta tcaaagaaac atcctccagg aagtatagta
    12241 actggttgac cacctgcatt tacaatagtt tcatcacttg aatttccatc ttcggctgaa
    12301 cctaaaccta aaaagccatt ttcagattgt aagataacgt ttacattatc cggaatataa
    12361 tttgctactt tggttggtag acctattcca aggtttacaa cggctccgtc ttttaattct
    12421 ttagatactc tatttgcaat atattcttgc atttctaatt tatccattat aaattacctc
    12481 cttcaatgat gtaattcaca aaaatacctg gtgtattaac ttcatttggg tcaatatcac
    12541 caatttcaac gatttcatct gcttcaacta ttgtaatttt ggcagcagat gccattaaat
    12601 tattaaaatt gttcatagag cctttataaa ctagattacc tgctttatcg acctttgatg
    12661 caaatagaag agcaacatct gcataaattg gtttttcaag aaggtattct ttgctatcga
    12721 caacaatttt ttgctttccc tcctcaacaa gagtaccaat accagtcggt gtgagtatac
    12781 ctcctagacc ataaccagct gcacgtattt gttcagcaag agttccctga ggaactaact
    12841 caacatctgt ttcattgtta ttcatttgtc ttccagtttc tttatttaat cctacatgag
    12901 aagcaattat ctttttaaat tgcttattta caaccatttt gccaactcct ttgtcaataa
    12961 agccagtatc attgcaaatt agtgtcaaat cttttatatt tttactacat aaataatcaa
    13021 ttaaattttc tggtgaacca ttggccatga atccaccaac cattattgta tctccatctt
    13081 ttacatgaga tagagcttca tcaatgctaa ctattttatt catatttcct cctatcgtga
    13141 aaccaccatt gatattcctt gaccaccacc aatacaaagt gttgcaagtc cagtttcaac
    13201 tttacgtttt tgcatttcat aaattaaggt aacaagtatt ctagctccac ttgctcctat
    13261 tggatgtcct aatgctattg caccaccatt aacatttaac tttgatgaat ctatttgaag
    13321 ttcattttta acagctaatg cttgggcagc aaacgcttca tttgcttcta ttaagtctat
    13381 atcattgatg ctaagtccag cttttttcag tgcttttcta gttgcaggga ttggaccagt
    13441 acccatgact tcaggttcaa caccagctga agcataggat tttattttag caagtggtct
    13501 aatacctagt tcgtctgctt tttgttggct cattagtatt aacatagccg caccatcatt
    13561 aatacctgag gcatttccag ctgttacagt accatctttt ttgaatgcag gtttaagttt
    13621 agctaaacct tcaaatgtca tacctaattt aggatattca tctttatcaa tagtttctat
    13681 ttttcctcga cgtattaaaa catctactgg aacgatttct tctttaaagc ggttgttttt
    13741 tatagcattc tcagccttac tttgactttc taatgccaat ttatcttgca tttctctagt
    13801 aaattcaaat ttagttgcaa tattttctgc agttattccc atatgatact gattgaaagc
    13861 atcaataagg ccatctgtta gcatactatc taccatggtt atgtcaccca ttttactacc
    13921 aaagcgagca gttggaacga tataaggagc ttggctcata ttttcagtac cacctgcaat
    13981 taccacatca ttttcaccag atgtgattga ttgggcagct agctggacac ttttaagccc
    14041 tgaaccacat aatttattta ctgtgtagct tggaacagaa tttggtatac ctgcatttat
    14101 agcaatttgt ctagcaacat tctgtccaag ccctgtttga agaacatttc caattattac
    14161 ttcatctatt tcagataaat taagtcctac acgtgatatc gcttctttaa cagtgatagt
    14221 tccaagttga acagctgaag tatttttaaa tacacctcca aaacttccta taggtgttct
    14281 gactgctgat acgattacta catctttcat atctaatagt tacctttctt gaatgataat
    14341 taaaaatttt ctgaataaag aaattaggaa acactataat aaagtacttt tttaatacaa
    14401 gcttgttttt aagtatttca attactttta ttcctaatgc tttaggtttt cctgtttcta
    14461 attatagatt acggcgaaaa aagcgttttg tctaagtcta attttttata tagtgtataa
    14521 gaaaaattta taggataaaa atttatagta gatttagaaa aatattttgt taaaatatta
    14581 atgaaattat gttgattttc ctataaaata tcattagaag aaaaaatata atctaaatta
    14641 tacttttggg gaagggggtt taaaatggat ataaaacagt tgaaatattt tgttgaaata
    14701 gtgaaatctg gttttaattt atcaatagca tctaagacac ttcacatatc tcaaccagca
    14761 ttaagtcaaa ttataaaaaa ttttgaagaa agtgaagatg tatatttatt tgaaaggtat
    14821 aaaggcaggt taaatgggtt aacaccagca ggagaaagat tttatgtaaa tgcagaacat
    14881 atcataaatg aatacaaaaa tatgatggaa gatttaagag aagattcagt tcaatttaaa
    14941 ggaaaagtta gaataggaat acctccactt atacttggaa tagcattttc agatgtagtt
    15001 gcacagttag ttgcaaataa tccagatata gaatttgata tagtagagaa gggtgcatat
    15061 gacttaaata gaatgcttat cttacaggaa ttagattatg cagtattgtt acatccacat
    15121 aaaattgata aaagtgtagt aactgaacat gtgcttcaag aagatgaact tacagcattt
    15181 ttaaatataa atcatccact tgctaagaag gataagatag attggaacga tttgaatgag
    15241 cagttacttg caatatttaa tcctactttt atgatacatc ataagctaat gcaaaaattt
    15301 actgatgaaa atgttaagtt aaaaagatat ataatgtctg gttcatggga ttttttgttg
    15361 ctatcaacca caaattctga ttttataaca attctaccat caccagttca tgattttttt
    15421 gaaaatagca aaattataga aaagcctttt aatcatccta ttacatggaa agttatatta
    15481 tgtagaccta aaaaagaacg ttatagccat gtagaccaac atgtatttaa atttattata
    15541 gatttcttta gtaaaaagaa ctcttaaaaa tgttattaaa ataacaaata aataaatcaa
    15601 tttttattat aataaactat tagtttttca tctatatgtt tgagagcaat aataggtttt
    15661 acataacatg gtagagtagt atttaaagtt ataatataca aaatatgtat ttttttaaac
    15721 gaaaaataaa aacagtgtat atctttagat aatcactgtt tttattttct atataaaatt
    15781 tgttaagtat tactagaaaa ttttttgctt attatagtca aactcatgac tgttaaaaat
    15841 ataagtaatc ctggaaatac agctaaatat aacttgtcaa aaatatgtct ttgagcatct
    15901 tgaagcatat taccccatga tgcaagaggc aattggattc caagacctaa aaaactaaga
    15961 gcagattcag ttaagatagc attagcaata tttaacgaac cagcaactac aatagtctct
    16021 tttaagttta aaactatatg tcttaatagt atatttctag tcttgatacc agtagcttta
    16081 gcagctagac agtattcatt ttcctttatt tttaatgttt cgccacgtac aattcttgaa
    16141 acttccatcc aacttaagaa tccaataatt agtataatag tggaaacttt aggtgttaga
    16201 taagtattta atacaatcaa aactaagaaa cttggtatac tcataagcat atctattaat
    16261 ctcatcaaga attggtctag cttacctcca atatatccac taataacacc tacagcagta
    16321 ccaaatacta cagaaataag cattgataaa ataccaacac taagtgaaat ccttccacca
    16381 taaagagctc tagagaagta atctctacca agttcgtctg taccaaagat atgctttaag
    16441 ctaggttctt gaagtttaga agtagtatca attgcattag agtctatatt taatataaaa
    16501 gaagctataa ttaatatgat tattatgcta agagtaatac atgcaaaagc aaaggattta
    16561 tcttttttta atttttttaa gatacttgta aacacaacta gaatcctcct ttgctagatt
    16621 ttattttagg gtcaattaat aagtatagta tatcagcaac taaattacct aaaattaaaa
    16681 atagtgctga taacatagtt attgccataa ttacagtata atctcttgaa aaaattgaat
    16741 caatcattaa tcttcccata cctggccaag agaaaactac ttctgtaaca aatgcaccag
    16801 tgactaattt ttgtatactc atgcctagga ttgtaaccaa tgatgtcagt gaatttttca
    16861 agacatgttt aaatagtatg actttttctg ataatccttt tgctcttgct gtaataacat
    16921 attgtttttt taattgttca tttacactag cttctacata atttgtaaaa atagcagtat
    16981 tatatagacc taaagttatt acaggcaaaa ctaaatgttt tactaagtct ccaatactat
    17041 catttccaat agtatgcata cctcctgatg ggaaaatgtt aagtttaact gaaaaaattg
    17101 aaatgagtat catacctatc caaaaagaag gtatagaaac acctatataa ttaaaaacag
    17161 atgatacttt actagttatt gaatttttat ttacagctaa aaatattcca agaggtatag
    17221 ctaccaatat tgaaaatatc aaagaagtac ccataagaat aaatgtattt cccatttttt
    17281 ccataatttg ttctgtaacg ggcatatggt ttatataaga aatacctaag tttccactta
    17341 aagtgttttt caaccagttt aaatatctta tatatactgg tttatcaagc cccatattaa
    17401 cccttatatt ttcaatatcc tgtgaagaca ttaaaggatt tatatatgca tctgctgggt
    17461 caccaggagc taattctaaa agtccaaatg ataatataga tattaagatt aacataggta
    17521 ttaaaacttt tactctattc aatattaatt ttaacataag taaattctcc taattaaaag
    17581 agatgtctcg ttttaaaata ataaaacaat attattttta gacatctcct tttctaatta
    17641 ataatataaa attttacatc aattattcta catacagttt agaccaatct tcaaataata
    17701 ttgcaggaga tggtttagca tcttttattc cttttagatt tttttgagct gccattaaat
    17761 tttgttcata atctatagtg taaataggcg catccttaga tatatcctgt tgtatttgct
    17821 tatatatttc ttcacgtttt tccttgttta actcagtaaa tcctttttcc cataaagcat
    17881 ctatttcagc attagaatat ttagtttggt tgcaatattg accagtttca aacatacctc
    17941 tatatgggtt tggttctaat ccccaagcat aaccatttac atacatatca cattcagtgc
    18001 tattactaaa tagtatattg aagaatgcct tactttcata aggaactatt tcagcttcta
    18061 taccaatttt tttcaactct tgttgagcta ctaaggcata gtttttatgc ccaaatctac
    18121 ctgtgttata acctattttt aatttatcaa ttttaacacc acttttatcc aataagtctt
    18181 tagccttatt tgtatcttgg tcatatcctt caacaccttc ttctgtatag aagtctgctt
    18241 ctggaactaa tatagattta gcaggtacag aaccttcttt tccatatgct gattctatca
    18301 tttcatttct atttaaggca tatgataagg cttgtcttac ttctttgtta gccatgtttg
    18361 atatattttg gttaaataca atgtagttta atctttcttc actataagta taagtttgta
    18421 agtttgagtt tgattttgcc ttttcatatc cttcagcaga tgtcttcata agtgaaattt
    18481 cgccattatt taaagctgct tcttgagatg cttcattagg aattattttt agcgctatag
    18541 aatctgcctt aggttctcca ccaaaataat ctgcattctt ttcaaatact atgctttcac
    18601 cttttttcca ttccttaaac ttgaatgcac cagaaccaac tggattatta tttttttctg
    18661 acttagctat atttgattct ccttcaaaca catgttttgg tattggagaa attttagata
    18721 taccatataa gaaagattca cttgcagttg gtaaagtaat cttaactgtt aaatcatcaa
    18781 ttttttctac tttaactggt ttctcaccca ccaataagta ttgtcttgat ggtgaatttt
    18841 gtttttcgtc taaaactgta ttaaatgtaa ataagacatc ttcagcagtt attggctttc
    18901 catcatgcca ttttaaattg gattttaatt ttatagttaa ttccttacta tctttaaaat
    18961 ctactttttc tgctaaataa tttactaaat ttcctttttc ataagtataa agaggagcat
    19021 aaactatatt tgatgcaaga gagtcttctt taacgtttgc aaaagctcca ttgattatat
    19081 ctgggtcact tgccataggt attacaacag ttccaccaga tttgcttcca ctagacttgt
    19141 ctttatcatt ggaagcacag gctgtaaatg taagcattaa tgatgaaact aagattaatg
    19201 atgccaattt tttaaatttc atattcttat aaaacctcca taaaataata tttaacacat
    19261 attttttatt gtataatagt aatcattatt aaatcaatat atatagaaat taactattat
    19321 attattataa ttaatagaaa aaaataataa aatgtaagaa aatgttgtaa tttaaatttt
    19381 tataaaatac aatcaaaagg tgtatgttat cttaagtaat tttgctgaga ggagaaaata
    19441 atgagtaaag cactaattga ggttaaagat ttaaaagttt attttcatac agataaaggg
    19501 attgtaaaga gtgtaaatga agtaagtttt aatataaatg aaggtgaaac tattggaata
    19561 gttggagaat caggatgtgg taagtctgta acagccatgt ctttgatgaa gttacttcca
    19621 acatcaaaaa tagaaggtgg agaaataatc tttcgaggca aagacatttt aaagatgaat
    19681 gaagatgaac ttatgggaat aagagggaat gagatatcaa tgatttttca agaaccaatg
    19741 acatctttaa acccagcgtt tactgttgga agtcaaatca ttgaaggtat tatgatacat
    19801 caagatttat caaaggaaga agctaagaaa aaggtaatcg atatgataaa actggtagaa
    19861 ataccaagag ctgaagaaat atataattca tatccacatg aattatcagg tggtatgaga
    19921 caacgaataa tgatagctat ggctttatca tgtaatccaa aattacttat agctgatgaa
    19981 ccaacaacag ctttagatgt tactattcaa gctcagattt tagatataat gaaaaatata
    20041 aaagaaaaat taaacacatc tataatgatg attacacatg atttgggagt agttgcagaa
    20101 atgtgtgaca aagtattagt gatgtatgct ggcaaaatta tagaagtggc agaggttgtt
    20161 gaattattta aaaatccaaa acatccttat actattggac ttctaaaatc aaagcctgct
    20221 cttggaaaaa acaaagataa aagattgtat tcgattccag gacaagtacc aaatccaatt
    20281 ggaatgccag attcatgtta ttttagtgat agatgtgaaa aagtatgtga taaatgtaga
    20341 actcagatac ctcctttaat agaattgaat agtggtcata gtattgcatg ttggttatat
    20401 aaaaaggagg agatataatt gaaaaaagaa gagagtttat taaaagtaga aggtcttaaa
    20461 aagtactttg aagttaaatc tggattattt gataagaaaa ttaaatctgt aaaggcagta
    20521 gatggaattt cttttgattt aaaaaaagga gaaactttgg ctatagttgg agaatcggga
    20581 tgtggaaaat caactgcagg aagaaccatt cttagattaa ttgaaaaaac tgaaggtaaa
    20641 gttgaattta atggtgtaga tatatataag ttagagaagg aagaacttag aaagttaaga
    20701 cccaaaatgc aaatgatatt tcaagaccca tatagttcat taaatccaag attaaatgtg
    20761 gaacaaataa tatccgaggc agttatagaa cataatttag tgccaaagaa tgaaataaaa
    20821 gataatatat taaatgttgt agaaagttgt ggtctttcta agtaccattt aaatagaaaa
    20881 ccaggtgagt tttctggagg tcaaagacag agaataggta tagcaagagc attagcatta
    20941 aatccagaat ttatagtttg tgatgaacct gtttctgcac tagatgtttc tattcaatct
    21001 caaattataa atttacttat ggatttacag gataaatata aactttcata tttatttata
    21061 tctcatgatt tgagtgtagt aaatcatatt gcacatagag tttgtgttat gtatctaggt
    21121 tctataatag aaattgcaac taaaggagaa ctttacttac attctcaaca tccatataca
    21181 aaagcactta tgagcgcagt accaatacaa gaccctacaa ttaagaaaaa tagaattata
    21241 ttaaaaggag acataccatc tccaacaaat ccaccaagtg gatgtaagtt tcatacaaga
    21301 tgcccttatt gtaaggaaat atgcaaaaaa gagattccag ttttaaaaga aatatcaaga
    21361 aatcattttg ttgcatgtca tctagtatag atatttcaaa aattaaattt gatgtatata
    21421 ataagaataa tagaataaac tgaaaatttt tttgattaag atgggatttc atgctgttaa
    21481 tattaagtta gttgatatat aagtttaatc tataatatta ttattgaaaa gagaggtagt
    21541 tatgtcaatt ttagtaacat tgttgggatt attggtttgt acaacgattt caactgtatt
    21601 tagcaaaaag tggagtaata ttcctcttgc aatatatcaa attgtactag ggattatatt
    21661 gtctattttg ccatttaaat tctcattttc atttaatcca gaaatatttg taatatgtat
    21721 catagctcca ttactattca gtgaaggaca aaatgtatcg agaaaagagc tattagagct
    21781 tagaaaacca attttgcttc ttgcatttgg tttagtttta ataaccgtgt ttgcaggtgg
    21841 aatctttata cattttctta ttcctgggat gccattatct gtttcatttg ctttggcagc
    21901 agtaatatct ccaactgatt tagtagcagt aaaatcaatt acacaaggat taaattttcc
    21961 taaaaatata atgagtatac ttgaaggtga atctttatta aatgatgctg ctggagtagt
    22021 agcatttaag gttgcagtac ttgctacagt tacaggagtt ttttcaatag aagaggcagg
    22081 gattcaattt atgattacag cttttggagg aataatagta ggaagtattt taggatacat
    22141 aattataaaa ataagactta gtttacacaa gtggaatttg gaagaaattc caatggtaat
    22201 agttatacaa ataatgactc cactttttgt atattttgta gcagaagaaa taggagtatc
    22261 tggaatccta gctgttgtaa tggcagggat agctcatgga attgaaaaag agcatttaca
    22321 aaatacaact actaaattaa ggataatatc agacaatact tggtatgttt tggagtatgt
    22381 attgaatgga tttgtcttta cactgcttgg ttttttgtta ccaagtatat atacaggact
    22441 tagtagtaaa aatgaaaata tggcattgga attgactttt atttctactt taattgtact
    22501 tattttattt gttataagat ttatatgggt atatttatgg cataattctt ttataaaacc
    22561 taaaaagaat cctttaaata atttttttgt aggtttttta ggttttaagg atgaagaagt
    22621 tataaaagag agtatttcta aatgtaaata ctcactaata gttgctactt gtggtgttca
    22681 tggtacattt acactagcaa ctgccttatc tatacctttt tatttggctg ataaagatgt
    22741 atttccaatg agagatactg ttttatttat atcatcagaa gttattctta taagtttagt
    22801 attggcaaca attttactgc caagattatt aaaaaataac gtacaagagt cagaaccttt
    22861 attatctgat aaagaggcat ataaactaat tttgaaagaa gccattttaa aacttagtaa
    22921 tgaaaaagca caagaagtac aaccagttat acatgattta aatgaacagt tggtagactc
    22981 agaaaaagga atactaaata ctccagataa taaacttata agtatgatga ttgcagaagc
    23041 agaccaacag ggattattag ctgttttgaa actattagaa gatggtaaaa tttctgatag
    23101 agcctttaaa ttgtatagat tttatattac aaaatcaaga aaatctgttc aaaaatctat
    23161 atttaaaatt gtaaaattaa aaataagcat gtggattata aatagaaaag taaagaaaga
    23221 agtaaaagaa aaaattacaa aaatagtatc tgagaataaa gaaataatca aagagtttca
    23281 ccatgcatat gcactttcta ctaaaactgc tatatcattt ataaataaaa atactgatga
    23341 agataacaga catgaggcct taatagcaat cagattctat aatcgttatt tgaattggat
    23401 tactagaaag attcaaaatg atgataagtt tgaggcaaga gtagaatact acagagtaat
    23461 ggcgatacaa agtcaaagag acagtgttca acaattagtt gaaactaagc aaatatcaag
    23521 agaagtggct aaagagttat tggaaaatat tctctatgat gaaatgatga tgatagaatc
    23581 ataaatataa tggaataaaa tttgattttt gatgttaaaa ttaatactaa aaaataggaa
    23641 atagttttca ataatttact tgacatatat atttatttat aatagaataa aaccataaat
    23701 tgaatacaat atataagcat taacaagctg gattgttact ggtaagcagg caatacctag
    23761 gttaaggtat acaggtgaat tgtatcttaa tttaggtatt tttttatgaa taagggaaat
    23821 tgtattttgg gagagatatt gattatgatt attcaacaaa tttataataa taatgttgta
    23881 ttagttttag atgaaaatat aaaaaaagaa ttaatattaa caggatgtgg aattgggttt
    23941 caaaaaaaga aaggtcaaga aatagataaa agtaaaattg aaagaacttt tgtaatacaa
    24001 gatgaaagct ttttagataa aattagtaaa ctagcaagcc aggttgatga gaaatttttt
    24061 gaggttagta ctgaaataat tgcttatgca gaggagaact tgaatactaa gctttatgaa
    24121 tatatttatg tagcacttac tgaccatatt gcatttgcaa ttaaaagata tcatgaaaac
    24181 ataactataa agaatgattt actacatgag ataaaaagaa tacataaaaa agaatatgag
    24241 attgggaaat gggctgtaga ttatataaat aaagaatttg atgtgaaatt tccagtagat
    24301 gaagctggtt ttatagcaat gcatatagta aattcaaact ataagggaag ttcaaaggaa
    24361 tcactattaa ttactaaaat tgtaaaagac atactaaata ttataagata ttattataga
    24421 gttgaattta aagaagatga tataaattat gataggcttc tgactcattt aaaattcttt
    24481 gcaaaacgat tagtaaaaaa agaaaaaatc aatgatacaa ataatgaaat tatagatata
    24541 attaaagtaa agtatgaaaa ggattatgat tgtgcatata aaataaaaac tcatgtagaa
    24601 aagaattatg attactatgt aagtcaagat gaactacttt atttaacatt acatatcaaa
    24661 agagttatat ctgtactgaa tttataataa agagtagttt aatacagaat gtatagattt
    24721 aatatattat gtttaatttt aatatattat ttaaaattta atataaaata ataattttaa
    24781 aacattaaga ttgttactga taatgcaggc aagacttatg tttataaaaa aattataata
    24841 gtttattttt aattctgaaa ttaggttaat ataggtttat ttatattaac ataagtttaa
    24901 ttttagaatt aagtatacta atgtaacttt ttataaactt aagtcttttt tatttaaaaa
    24961 aatataaaat aataaggaga gaaaagtaaa tgaaaaaagt atttggtgtt ttacaaaaag
    25021 taggaaaatc tctaatgcta ccagttgcat tacttcctgc agcaggtata ttacttggcg
    25081 tgagtaatgc tttagcagga gacgcattgt tggctcattt tccagctttg gcgaatccta
    25141 catttcaact tataataagt ataatggaaa gttcaggtca aattatattt aataacttac
    25201 cacttatatt tgcagttggg gtagctgttg gtttaactga aggagaaggt gttgcagcat
    25261 tggcagccat agtaggtttt ttaattctca atacatctat gggtgttatg gcaggtgtta
    25321 cagaagatat ggtagacaat tctatgtatg caaatattgt tggaatacca acaattcaaa
    25381 caggggtatt tggtggcatt attataggga tagtggctgc ttatctttat aaaaagtttt
    25441 ataaaattga attacctcag tatctaggtt tttttgcagg taaaagattt gtaccaatcg
    25501 ttacttcatt agttgctata gcaataggaa ttatattgtc ttttatttgg cctccaatac
    25561 aagagggatt acttagtttc tcaaaaaatg ttatagaagc aaatcaaaca ctagcagcat
    25621 ttatggaagg ttctttggaa agactattaa taccatttgg tttgcatcat gttttccata
    25681 atccattttg gtatcaattt ggagaatatg taaataaagc tggtgagctt gtaatgggtg
    25741 accaaaagat attctttgct caacttaaag atggagtaaa tttcacagca ggtactttta
    25801 tgacaggtgc atttccattt atgatgtttg gtcttccagc agcagctctt gctatggtgc
    25861 atgaagcaaa gccagaaaag aaaaaatttg tagcaggtat aatggcatca gcagcattaa
    25921 cctctttttt aacaggaata accgagccaa tagagtttgc gtttttattt gttgcaccag
    25981 tattatttgc aatacattgt ttattttcag gtttatcata cgcaattatg caattattag
    26041 gagttaaaat tggattcaca ttttcaggag gattaataga tttcttatta tttggtgttc
    26101 ttcctaatag aactccatgg tacttggcta tcttggtagg tattggtttt gcagtattat
    26161 actatagtgt atttagattt atgataagaa aatttaattt aaagacacca ggaagagaag
    26221 atgagtcaga aactaacgct gaagtcattg aaatgtctaa gaatgaatta gcatcagaga
    26281 ttttgattgc tttaggaaat aaagacaatt taaagagcct agatgcgtgt ataacaagac
    26341 ttagattggt tgtaaatgat ataaataaag tagataaaga aaaattgaaa tcacttggag
    26401 cagcaggtgt tatggttatt ggcaacaatg ttcaagctat atttggacca aaatcggatt
    26461 caataaagtc tgatataaaa gatataatag agggaaaaac aaaggttgaa agtactgtta
    26521 ctaaaaatgt tgataaaaat aaagtgaaaa aaaatatgga agttgcaaat atggaaaatg
    26581 ctttagtaga aaagattgat tcattaacaa atggagagat attagatata gaagaagtgc
    26641 cagattctgt attttcaagt aaactgatgg gggatggatt tgcaattaaa tctagtgatg
    26701 gattgattta ttcaccagtt gatggaacta ttggagttat atttccaact aagcatgcaa
    26761 taataataaa atcccaaaaa agtggagtag aaatacttat acatttaggg atagaaactg
    26821 taaatttaga aggaaatgga tttgaagtat ttgtgaatgt aggggatgaa gtaaaagcgg
    26881 gagaaaaatt agttaaaatg gacttagaat atattgaaaa aaatggtcta tcaacaataa
    26941 gtcctgtagt atttacgaat ttagaacaaa atcagaaatt aagcattaaa aaaggagtaa
    27001 gcacagcaaa agaggagaat agagtaagta tattaagaga tgatattgaa aaaataggat
    27061 agctatatga tagtgtaact aaaagttatg tgggatttaa taaatatata aataggttca
    27121 gttaacatgc aatttattta atatatattt taagtaatag aaatatatat cattatattt
    27181 tgatatattt taaaacatta aaaaacttga ggtattagta agataaatac actaatactt
    27241 caagttttat taaaataaaa tttacataaa ttatctattc atctaaaaga gtaatatcca
    27301 aaggattttt attgtttata taatttttag gagatacccc gtagtttttt ttaaatgccc
    27361 ttacaaaact agaataatcg ttgaatccac atttattaca aacttcactc ataaggtgac
    27421 cattggttat tagtgacttt gccaaaatta atcttttttg aactatataa ttgtgtatag
    27481 acgttccagt atgagattta aattttctca taagataata cttacttata aaaaattcag
    27541 acgatatgct atctattgaa agcttatcat ctatatttga atttatatag tttaatactt
    27601 tcttaatagt ttcatcataa aaaacatctt ctgttgattc catattttca ttttttagga
    27661 aaattctgtt taagaatatc ataagttgta taaataatgc atttctcaat atttcatttc
    27721 caaattcagt attggattcg gaaatattta tttgctcaat aaaactctta atagattcaa
    27781 tatcatgtat atttaaacgc aatctattgc atttattctc tgtagctatt ttaaaacatt
    27841 tttctaagtc actactagca tcactatttt ttttcataaa ttctgggcta atccatattg
    27901 caattctctc ataaaagaca tttgaatcta taactggttt atgtatttca ttattgctga
    27961 taaagagtat atcccaaggc tttagtttat agggaatacc atcaacaaaa taagttacat
    28021 ttccatttat aaatataatt atcttattaa aatcatgatt atggtattca aattgtatat
    28081 cttttttatc tctaatatta aatattttaa agttatcgtt taagtacccg attttattat
    28141 ccatagtttt tatagaagac ctttcctcag ttatattata gaaaattata gagcattttt
    28201 tgcaatgttt caagcatttt taaccattca catagtaaaa aattcttaat ataatattat
    28261 atgtagtgta attttagcag aaagagttta aagggaggaa agcatttatg aaattaaatg
    28321 atattataca ggggttggat ataatcaata tcaagggtga attaaatata gatattaata
    28381 atgtacaata tgattcaaga aaggttacaa aaggtacatt atttatatgt ataaaaggat
    28441 ttgtgtcaga tggtcataag tatataaaag atgccataga aaagggagca agtgcatttc
    28501 ttgttgaaga agatgtagaa ataaaaggat gtacatttat aaaggtaaaa gatacaagaa
    28561 aagatatggc aaaagtagct gataattttt acaatcatcc atctcaaaaa tttaacgtta
    28621 taggagttac aggtactaat ggaaaaacta gtataactac tatactaaat gagatattaa
    28681 ctttaaataa gaataaagtt ggacttatag gaactataaa aatttttgat ggagaaaaag
    28741 acattgtttc caattcaaca actccagaaa gtatagattt acaatatcat tttaataata
    28801 tgttggataa tggatgtgac tactgtgcga tggaagtttc atcacattca ttggcattaa
    28861 atagagttga tgaaacagac tttaaactag gcatatttac aaatttaaca ccagaccatt
    28921 tagattttca taaagattta gaggattata gaaaagcaaa agaaaaatta ttttttaaga
    28981 ctactatggc aaatataata aacatagatg atgaaggtgg aaaaaagata tatgaaaata
    29041 taaaaggtat aaatgtacct tgttacactt atggtgttga tactaaggct gattttatgg
    29101 ctagagatat aaaatcagat tcggatggag tatcttatag attaataaca ccttcatatg
    29161 aagaagtaat atttatacca gttccaggaa tgtttacagt atataatact ttagcagtta
    29221 tagctgcttg ctatgtactt ggcataccta aaccaatata taaagaaggc cttagacttt
    29281 ctaatggagt atcaggaagg tttgaaacag ttccaaatga taaaggtata agcgtaattg
    29341 tagactatgc tcatactcct gacgcacttg aaaatgtact aaagacaact caacaatttg
    29401 cagaaggaaa aataatttct gtgtttgggt gtggtggaga tagagatact gaaaagagac
    29461 ctttgatggg agcaattgga caaaaatatt ctgatttatg tattataact tctgataatc
    29521 caagaactga agaaccagag gcaataataa aagatatact tgaaggaatt gacaagaaaa
    29581 aagaaaatta ccatgttgtt gttgataggg aacaagctat agcagaagct ataagtatgg
    29641 caaaaaagga tgatgttgta attataacag gtaagggaca tgaaacttat caaattatag
    29701 gtaaagttaa gcatcatttt gatgataaag aagttgcaaa tgagtgttta agtaagatgt
    29761 agcataaaaa ttaaacaaaa tacaagaaca aaaatgtaat atcaagcttc actttgatat
    29821 tacatttttt tatatgtaaa taattgtaaa atagataatg caataatata aacactaata
    29881 tctatattaa ttaatttatt gttgtaataa agtttataat tttgtataat tacagtaaat
    29941 atggaaaaat aagtattatt ataaaatgtt tacaataatt gtcataagat aatgattata
    30001 catacataga ttcgagaaag gcaggaagca taatgttaag tgatgcaaaa aataataggt
    30061 atggtttgtc cataattgct gtcataagta tcttagtaat tacaatttcc tgtttgattt
    30121 atggttcaag gttgaataag acattaggtg aagaaacgaa tcaatatctt tcagaaatag
    30181 caaatcaaag tgtcaatgtg ttaaaaaaac aaattaatgg agatataaag ttactagagt
    30241 caatttcaat atttattgaa ggagaagagt cttttgaagt agataatatc ctttctatac
    30301 taaaaagaca agctattaat agttcattta aaagaatggg agttatttta ccaaatggta
    30361 cagcatacac tacagatggt tatatagaag acttctctaa aagagattat ttcttaaaat
    30421 caatgcaagg agaagtggtt ataacaggca aattaaaaga tgtaatagaa gatgataaaa
    30481 ataccaatag taatattaat gtatattctg taccaattta taaagataat gaggttaaag
    30541 gagttatatt tgccacacat agtacgaagt tgtatgaaaa aatactttct gtacctacat
    30601 ttaatggaaa aggatattct tatataacta gaagtaatgg tgatattgtt ttaaatccaa
    30661 gcagtaaaaa cgccaactct actaaagaaa atttattttc ttacattggc agaagtgatt
    30721 caatatcaaa atctagtatc aacaatatga agtcaaatat aaaaaacttt aaatcaggtt
    30781 cattaagtta tagtatgttt ggaaaaggat attatttaag ttatgcccca ataggaatca
    30841 atgattggta tcttttttct gaagttccta aaactgctat atctgagaaa tcatatgcta
    30901 ttataaaact tacattatca gcatgtgtag tcttgattat aatctttacg gcattaacaa
    30961 tttatatact atttatacat aaaaagagta aggaaaaatt ggaagaattt gcttttaaag
    31021 ataacgttac aggtattggc aattcaaata aatttaatct tgaaggggga aaatttttat
    31081 cctctcatga gaaaaagaat ctagttttaa tttattttga tatagataag tttaagctag
    31141 taaatgatag gtttgggtat gaagaaggag atagagtatt aaaggaaata gcagagataa
    31201 ttaagaatat atttaaagag caatctgtat tttcaagaat ttcaaatgac aattttgcta
    31261 taatatttga aaagaaaaat aatagagagt caattataga aatatgtgaa cttatacgta
    31321 aaaaattgtc aatgataaaa acaagtttgg gagtagaact caatttaatt ccatccatag
    31381 gtgtatattt tgttgaagag ggagaaacaa atatttctac ctgtcttgac aaagctatga
    31441 ttgcaaaaac tacagtaaaa agaaaatatt taaaagttta tgagatttat gctgaaaatt
    31501 taaaagaaac tctcatagaa gaacgtgata ttgaacaaga aatgcatgat gctttaaaaa
    31561 atgaacaatt taaagtttat ttacagccta aggttgattt atcaactact aaaattgtag
    31621 gtgctgaagc acttgtacgt tggcaacatc ctaaaaaagg tctaataagt ccaggtgtat
    31681 ttattcctat ttttgagaaa aatggcttta taacagaatt ggatatgttt gtatttaccc
    31741 aagtttgtaa aaattttaaa cgttgggaaa atgaaaattt ccccacattt cctatatcaa
    31801 taaacttatc aagagtacat cttgagaatc caggctttat ttctgagctt gaaagaataa
    31861 caaaagaata tgaaattgaa ccaaatttaa ttgagattga attgacagaa agtgcaatat
    31921 ttgacaatac aaaaatatta tttaaaataa tgcaaacttt gaaatctgtt ggatttaaaa
    31981 tttctatgga tgattttggt tctggttatt cttctttaaa tatgcttaaa gatatgccaa
    32041 ttgatgtatt gaaattagat aggcaattct ttataacagt gggaaatgca aaaaagagtc
    32101 aaattgtagt ttcaagtatt gttcaaatgg caaagcaact tgatataaaa gttgtttcag
    32161 aaggtgttga aactgtagag caagcagagt ttttaaggtt tataggttgt gatatggccc
    32221 aaggattttt atttgctaga ccaatgccaa tagaagaata tgaaaaatta atattagata
    32281 gatatagttt aaatagaaaa gaaacaaatt aaataaaatt gtgaattata acataaaaat
    32341 ttataaaaaa gtgaactttg ttaatcaatg ttcacttttt tatgtaaaaa tatactatta
    32401 taaaaacata aatcattgtt aggatattat tttaggaatt attgggcaaa gtttattaat
    32461 atgtagtatt ttttacattt gaatgttttt gaggtaagag tatatgggat tatagcaaaa
    32521 tactttagat agtaataata gtaatttcta taggtgtgtt atacatattt taaaaaataa
    32581 aaatataatt tataaattta aatgttatat atgtaagtaa ttttattata tcaaaaaaag
    32641 agtttttcat aatcatttat acaaatcatt tgaaatactc ttcttttatt tttaaattct
    32701 atataattat tataaggtaa tattgtatta ttataatctt agttttttag ttattatata
    32761 taatagtcaa agtgtatacg attaatcatt ttaaacatta aatctaaata atattacatc
    32821 tccatcttta actatgtatt ctttaccttc taatttaacc aacccttttt ctttagcagc
    32881 agccatagta ccatgctcaa ccaaatcatt aaaggctatt gtttctgctc tgataaatcc
    32941 tctttctata tcagaatgta tttttcctcc tgcctgagga gctttacttc caacttttat
    33001 agtccatgct ctaacttctt ttggaccagc agttaagaat gaaattaaac caagtaaagc
    33061 ataagaagat tttataagct tatcaagccc tgattgttca agacctaatg tttctaaaaa
    33121 ctctttcttt tcttcagcag aatcaagttc agaaatttct gcttctattt gtgcacatac
    33181 tacaacaact tcggcatctt ctgtttctgc aaatgcttta acttgttgaa catatttatt
    33241 attttctcca ttatcagcta aatcatcttc tgatacattt gaagcatata ttacaggctt
    33301 agatgtaagt aaatccaatg aatttacgaa tgtttgttca tcttctgtaa attccatagt
    33361 tcttacacac ttactttctt ctaaagtaga cattattgat tttaataaat caagttcaga
    33421 acctaaagtt ttatcagcct tagcagcttt ttgagtttta ttaattcttc tttcaagaat
    33481 ctctatatct gagaaaatta attctaagtt tatagtttct atatcacgaa gtgggtctac
    33541 agaaccatct acatgtacaa cattttcatc ctcaaaacat ctaacaacat gaactattgc
    33601 atcaacttct cttatatgtg ataagaattt atttcctaaa ccttctcctt tagaagctcc
    33661 tctaactaaa cctgctatat cacaaaattc tatagcagta ggaactattt tttcagaatt
    33721 atataattct tgtagtttgt ttaatctttc atctggaaca gatacaactc ccacatttgg
    33781 gtctattgta caaaaagggt aatttgcaga ttctgcacct gcttgagtta ttgcgttaaa
    33841 tagtgtgctt ttacctacat ttggtaaacc aactatacct aatttcatat taatcgtcct
    33901 ctctcttatt cttttttata ttctttatat aactttaaac aatcaatcta taggattgca
    33961 aaattgtttt aattatagac atacatattg attatacatc atatatatca agcttgtaaa
    34021 ctagacttta aagcatattg atttaaataa tatttgtatt taatttaaat aaaaatattg
    34081 cttttagaaa ataataaaaa ggatataatt aaatagaagg tttttatatg tgagtatatg
    34141 taattaaaaa ataaataaat ttcaatttta aaattgatgt ttaaataaaa ataggaggta
    34201 catatggtta atactaaaaa aataataaat ttaggtaata atattaatct tactttgata
    34261 aaaacagaaa agtttaaatc gaatcttata agtttatatg ttcagagact attggatgaa
    34321 aaagaaacta caaaaaatgc tctaatacca tcaataatag caagtggaag ctctaaatat
    34381 cctagtgcta gagcaatatc caataaatta gatgatttat acggttcatc tatgggagct
    34441 gatgctgtaa aacgtggaga acgtcaagta ttgagtttta aagtaattaa cataagtgaa
    34501 aagtatttag atgagagtat atttgaagaa gtagtagaat tttttaatga agtaataaat
    34561 aatacgcttg ttgtagatgg tgggtttaaa gaagaatatt taaatattga aaaagagaat
    34621 ttaagagaaa agatacaatc aataataaat gataaaaagg aatatgcgca agataaatgt
    34681 attgaggcta tgtgtaaagg agagagatat agtgtaagtg aatttggtta tgaagatgaa
    34741 atagatagta taacttcaag agagttatat gaacattata aaaacatact taaaacatca
    34801 cctatagata tagttgtaga aggtaatttt gatgaagata aagttgtaga tataataagt
    34861 aaaaatctaa aatttgaaag agaagaaatt ataaatatac caagagcaga ttttataaaa
    34921 aatgtggatg aggtaaaagt tatagatgaa caaatggaaa taactcaagg taagttagtt
    34981 atgggttata gagcaaatgt ggattatgca gacatagata aatattatgc tttagtagtt
    35041 gggagcaatg tcttaggtgg tggtccacac tctaaattat ttgttaatgt aagagaaaaa
    35101 gaaagtttat gttactatat attctcttca atagagaagt ataaaagtat catgtttata
    35161 tcatctggta tagaaactaa agattatgat aaagctgtag aattgataaa aaaacaagta
    35221 gaaagtgtaa aagcaggtga tatatctgat gaagaattag aaaacagtaa acttgcttta
    35281 gttaattcta tgaaatctat aactgataat ataggtggta tgtctgattt tgttttctct
    35341 caatctatgg caaagacaaa ttctgaagta caagatataa tatctagtat agaaaaggtt
    35401 acaaaaaaag atatagttga agctataaaa aatatagagc ttgatactgt atacttcttg
    35461 agaaattaat ggaggagatg tctatggaaa aaatagttaa tgatatattg aaagaagaag
    35521 tttattatga gaaattgcaa aatggattag atgtatattt tatgcctaaa aggggtttta
    35581 tgaaaaagta tgctatttta gctactaatt atggttcaaa tgacttagaa tttgtaccaa
    35641 ttggagaaga taagaaaatt agagtgaatg aaggtattgc acattttcta gagcataaga
    35701 tgtttgagca acctgatgga ggagatgcat ttgataaatt ttcaaaatta ggagtaaatg
    35761 caaatgcatt tactaatttt acaatgacag cctacttatt ttctgctact gaaaattttt
    35821 atgagagttt agaacatcta attgactatg ttcaaacacc ttattttaca gatgaaaatg
    35881 ttgaaaagga aaaaggtata atagcacaag agataaaaat gtacaatgat gaccctgatt
    35941 ggaatgtata ctttaattgc ttgaaggcaa tgtatgtaaa ttatcctgct agaattgata
    36001 tagcaggtac tgttgatagt atatataaga taactaagga agagctatat aaatgttata
    36061 atactttcta taatccagga aatatggctt tatttgttgt tggtgactta gatgtagaaa
    36121 aagttataga tgtaactaaa aagtcaaaca attacaaagt agataaactc tctaagagta
    36181 tagaaagatt ttatccagaa gaaccagaag gtgtaaaaga aaaagaggtt atagaaaaat
    36241 tccctatatc tatgcctatg ttcaacatag gttttaaaga tagtaatgtt ggtttaaaag
    36301 ggaaagaact tttacgtaaa gagattgtaa ctgatatact tgtagggatg ttatttaaaa
    36361 aaggaagtaa gctttatgaa gatttgtata tgcaaggttt aataaatgaa aattttggag
    36421 ctggattttc gtctcaagtg gattatgctt ttagcataat agctggagat tctaaagagc
    36481 ctaaaaaagt aaaagaaata attcttgatt atatagaaaa atcaaaaaaa gaaggattat
    36541 caaaagaaga gtttgagaga actaaaaaga aaaaaatagg gtcatttatt aagtgctttg
    36601 attctataaa ctttataggt aatagtttta tatcttatgt ttttaaggat ataaatctat
    36661 tggagtattt agatgttatt aaagatatta cttttgagga agttgaagaa agattaaaag
    36721 agcattttaa agaagagtat tgtgttattt ctattgtaga gcctaaatag aaacttaatc
    36781 ataataagaa taactaatta agtattagtt tatgttttta aatgtttatt ttggtaaaac
    36841 aaatttataa aatatattta tataaattga ggtaaaaatt taagagctat agataagaat
    36901 tagaagaggt tgatgtatat atgcatcaat ctttttgatt aaaaaatatc tatgtacact
    36961 tgtaacttta gtcatgagag attcagttta aaaaatttta tagtaattag atataatata
    37021 gtgtagggag ttgtagaata aattttaata ttttttgtag aattaacatt aatgtgttat
    37081 cataatttag tataattaca attaattgta attatagcat attgctttgg aaatattttc
    37141 aattaataca aagaggtgac gttatggata gagtagcatt tacactgttt ggcatagaca
    37201 tcatgtggta tggaatactt atggcatgtg gaatgatttt aggaacttta atagcaataa
    37261 aagaagcaaa aagagtggga attaaagaag atgatgtatt aaatatagct ataatagcaa
    37321 ttccagttgg actaatctgt gcaagaatct attatgttgt atttaattgg agttactatg
    37381 ctcaaaatat gtctcaaatt tttaatttta gaggtggtgg acttgctata catggagggt
    37441 taattggtgg aatattagct ggttatatat acactaagat taaaaatatt aacttcttaa
    37501 aaatggctga tacagttata cttggaatgc ctttagcaca agctattgga agatggggaa
    37561 attttattaa tggagaagca catggaggtg ctaccaattt accttgggga ataatggttg
    37621 atggagtaaa ggtacatcca acttttttat atgagtctat atgggatttt ggaatattta
    37681 tagttttatt actatttaga aaaaataaaa aatatgaagg tcaagttata gttacttata
    37741 taactttata ttcaatagga agatttttta tagagggatt aagaacagat agtttaatgt
    37801 taggaccact tagaatggca caagttataa gtctaattgg agttattggt ggcataattg
    37861 cacatgttta tttatcaaag aaaaataaaa ataatattag tgaagaatag tttaaaaagt
    37921 gaatttaagg gaggtaacta tggaatttca tcatgtatca gttcttttaa atgagtgtat
    37981 agagaattta aatataaagc cagatggcgt gtatgttgac tgtactatgg gaggagcagg
    38041 acattctaaa gaaatagtaa aaaaactgtc agataaggga ttatttatag ggtttgacca
    38101 agataaaaat gctataagca cagcaaaaga gagattgagt gaatatgaaa gtagagtgaa
    38161 gtttgttcac agcaattttg aaaatataaa agaggaatta gaaaaaatag gagtttacaa
    38221 aattgatggt gtattagctg atttaggagt ttcatctcac caacttgatg aagctgatag
    38281 aggattttct tatatgcaag atgcaccact tgatatgaga atggatgtta ggtgtgagtt
    38341 ttctgcatat gatgttgtaa atacttatac agaagatgaa ttaactaaga taataaaaga
    38401 ttatggagaa gataactggg ctaagcgtat agctaaattt atagttgaag aaagagcaaa
    38461 caaaccaata gaaactacag gagaattagt agatgtaatt aaaaaagcta tccctaagaa
    38521 agctagaata gatggacctc acccagctaa aagaactttt caggcaatac gaatagaagt
    38581 aaataatgaa cttggagtaa ttacaaagat gataaatgat gcttcttcta taatgaatga
    38641 aggtggaaga atatgtataa taacattcca ttcattagaa gatagaatag tgaaaaatgc
    38701 atttaagcat ttagcatcag attgtatatg tccacaacat ttacctatat gccaatgtga
    38761 taaagaatct gaggtgaaaa taataactag aaaacctata ttacctagtg aggaagaaat
    38821 agaagtaaat ccacgttcaa gaagtgctaa gctaagagta gcagaaaaaa tataagtagt
    38881 tataaggcta aagaataatc ttatatataa aataagatta ttataattaa ttaaaaagta
    38941 ttatatattt tgttgcactg gtaaagcaat taaaaaacaa ttaacactat aagaaatgtt
    39001 ctttgttatt gagatatata atgaaaattt agatataaaa atatagatat agatggtatt
    39061 aagtaatata atggagaact taggaatcag agagtagata gttagttaca tattatattt
    39121 atggaagaaa ttatctaaaa atactagaag tgataaaaat aaatagaaat taatatctaa
    39181 cctatagatt catataaaag tataagtgaa tttataggtt tttgttgtgt atagaaaaaa
    39241 atacaattag attgtgtaat agtgtattaa tttagcgatg aaattttaga ggaagaaata
    39301 tgattaataa caaatatagt atagaggaaa atttaaacta tatactatcg gggtgagaat
    39361 ttgaaaaaaa attataaaat acataatcta aatgaatata aaaataaaaa aaagaataat
    39421 tataaaaaga gaaataagaa aaaaatagga gctaaatgca ttttactgat tgcaactttt
    39481 tcagtaataa tattgaatct atgtggttat tcaaaaatct cggaaatgaa gtacgatatc
    39541 tattatttac aaaaagattt aagaaaaaaa gagatagtat tagaggaact aaaggcaaaa
    39601 gaaactgaaa aaacatcaat aaaagaaatt gagctaaagg ctaaggaatt gctcaatatg
    39661 gactatccaa aagatggaca aataaagtat atagatgtgg ataactaggg ggaatagatt
    39721 tgagaaaagt aaagaggata agtaagaaaa ggctggtact cgttcttatt ctagcatgtg
    39781 cattgttttt ttgccttgtt attaggactg ggtatctaca acttatgaag ggaaattggt
    39841 tgagtacaaa agcactagaa caacaaacaa gagatatacc aatagaaccc aaaagaggaa
    39901 ctatatatga tagaaatatg aaagagttag cagtaagtgt aactaagtat actgtttggt
    39961 gtaaacctgt ggaagtagaa gataaaaaag aagcagccga aaaggtagct gagattttgg
    40021 atgaagatta taaagatatt tacgctttaa taagcaaaaa aaatatggct cttgtaaaag
    40081 taaaaagatg gatagatgat gataaggcaa gtcaaataag agatgctaaa ttaagtggaa
    40141 tatgggtggc agaagataat caaagatatt acccatatgg gaattttgca ccatatgtgt
    40201 taggacatac ttcttcagat gcaacaggta tatctggtgt agaaatgcaa tatgataaaa
    40261 agttaaaagg aaagcctgga aaacttatag taagtactga tgcttcagga agagaaatac
    40321 cacaaggaat ggaaaaatat tatgagcctg tacaaggtaa tggtcttgtg ttgtctatag
    40381 atgaagtaat tcaacactat actgaaaaag cagtacagaa agcttatgag ttaaataatg
    40441 caaaaaaggt tactgcaata gctatgaacc ctaaaacagg tgatatactt gctttagcat
    40501 caaaaccaga ttatgaccct aatgactcaa gaacgccaat atatccatat tatcaagaag
    40561 aacttgaaaa atataatgat aaagataaaa taaaaggcta ttatcaaatg tggagaaatc
    40621 cagcagtaag tgatacatat gaaccaggtt ctacatttaa gcttattaca tcttccagtg
    40681 ctcttgaaga aggagtaatt aaagatggag aaaaattcac atgtacaggt agtgtaactg
    40741 ttggaggaag aaagattaaa tgttggagac attacagacc tcatggaaca caagaattta
    40801 aacaagcagt acaaaactct tgcaacccag tatttgttga gttgggaagc agattaggtg
    40861 ttggaaaaat gtatgattat atagaatcat ttggtcttat ggataagaca ggtatagatt
    40921 taccaggaga agctaaggga atactgtata acgaaaaaaa tgtaggacca gttgaattgg
    40981 ctacaatatc atttggtcaa tctatatcag taactccaat acaacttata acagctatat
    41041 catcaatagc taatggtgga gatttaatgc aaccaagagt ggtaaaatct tatactgaca
    41101 ataaaggaaa tataactgaa acagtaaaac caaaaaaagt aagaagtgtt atatctaaag
    41161 aaacatctaa aaaaatgtta gaaattgcag aatcagttgt aactgaaggt ggaggaaaga
    41221 tagcatatat accaggttat agacttggtg gtaaaacagg tacagctcaa aaagttatag
    41281 atggtaagta tgctccagga aaatatatat gttcatttgt tggaatagca ccttgtgatg
    41341 acccgcaaat agtagttctt gctattgttg acgaaccaac aggagtaagt gcatttggta
    41401 gtactacagc aggaccaata gtgaaagaaa taatgaatga ctctttaaaa tatttgggag
    41461 ttaaaccagt atataaagaa gaagaaaaag ctgagtatga aaagaagcaa gttaaagtgc
    41521 cagatgtaag aaatctaaaa ataggagatg ctgtaaaggc attggaggat gcgaagttaa
    41581 aaccagactt agatgcagat atagaacttc cagaagatac aaaggtaaag gatatattcc
    41641 caaaacctgg agtaaaagtt aatgaagact caagtataac cctatatttt gaaaactaaa
    41701 aagtaacaga taattaacat atacccataa acatcttcaa aaaaacagaa atatagtata
    41761 taattataaa gttaagagtt atcgtaggca atgtatatat aacggtatac attgcctttt
    41821 gttgctaaga gaatatagct aaggttttaa aggaggagtt taataatgga gtgcttaaca
    41881 ataaaagagt tagtacttgc aactaatggg aagttaatat atggagatta taatgactgt
    41941 gtaagtgata tagttataga tagcagggag gcaaatgccc aaaatgcatt tgtagccata
    42001 gttggagaaa atttagatgg gcatacattt atgaagtctg catatgatag tggatgtaaa
    42061 acttttataa aaaatgaaag taatggaata aaattagaaa gttcggatat aaatttaata
    42121 gaggtaaaag atacatcttt ggctctagga gatatttcaa aatactataa agaaaaattt
    42181 gatattccat ttataggtgt tacaggtagt gtgggaaaaa ctactactag agatatgatt
    42241 tactctgcca tatctgcaaa gttaaatata ctaaaaaatg aaaaaaactt aaataatcat
    42301 tttggagttc cattgacttt atttaatcta aataaagaac atgagtgtgc tgtaatagag
    42361 atgggtatgt ctggattcaa tgaaataaaa tatttagtgg atatagtaaa tcctaaaatt
    42421 gcagtcatat cgaatatagg attatcacat gtagaaaaac taggttcaca agagggtatt
    42481 ttgaaagcaa agatggagat tacttcaaac tttgatgaaa caaatacttt aattgtaaat
    42541 ggagatgata agtttttatc tacattaaaa gaaaaagaac atgtatataa gttaaaaaca
    42601 tttggcttta ataaaaacaa tgatgtttat tgtgaaagtt atactatgga agaggatagt
    42661 ttaacattta tatgtgtaat aaatgggaaa aaagaggaaa tatttatacc aacaatagga
    42721 gaacataata tatataatgc aatgtctgct atattagttg gtttgtgtct aaatatttct
    42781 ttagattata taaaaaaagg tttaaaaaat tttaaaggga caaaaatgag attagacata
    42841 ataaaaaatg aaaaattaac aataattaat gattcatata atgctagtcc agattctatg
    42901 gatgctgctt taaagatact tggaagatat aaaggtagaa gggtagcgat acttggagat
    42961 atactagaaa tgggtgaaat ttcagagtat ggtcatagat tagttggaaa atcatctatg
    43021 aataatactg atattataat aactataggt gaaaattcag tgtttattgg agaagaagca
    43081 aaacaattag gattcaattc agccaatata tatcactttg agaatagaga agatgtgttt
    43141 aacaagttaa atgaattagt aaaaacagga gacactattt tagtaaaagg ctcaagaggc
    43201 atgagattag aaaaaatagt cgaatatcta aataaataag cttaaactaa tgagttaatt
    43261 gacaagggag aggagtttta tgatgttagg aataacagag cttacgtaca ccgcattgat
    43321 tgcgttttta atagtaatta taataggacc aatatttata ccaatgctta gaaaatttaa
    43381 atttggtcag acagttagag atgatggacc ccaaacacat ctagctaaaa acggaacacc
    43441 tactatgggt ggaattataa tgattgttgc aattctaata actggactta caagagtaaa
    43501 agttagtcat gatatggcag taggtcttat atgtattgca ggttttggtt ttattggctt
    43561 tttagatgat tttataaaaa taaagctaaa aagatcactt ggactaaaag catatcaaaa
    43621 aataatcctt caagttgcat tatcttttta tgttgctttt tatcagtata catcatcatc
    43681 aagtgcttca caacttatga taccatttac agattttgtg ataaatgttg gaatattata
    43741 tataccaata atgatgttta taatcgtagc aatagtaaat gctgtaaact tgactgatgg
    43801 attagatgga ttagcatcag gagtaacatt aatagtttct gtattcttta tgctatttgc
    43861 aagttctatt gctggaaata cagaagtcgc agttttagca gcagcaactg ttggagcatg
    43921 tttaggtttc ttaggattta attcatatcc ggctagagtg tttatgggcg acacaggttc
    43981 aatggcatta ggaggtgcag ttgtagcatt ttcagttcta actaactcag tgcttataat
    44041 acctataatt ggaggaattt attttgcgga ggctctatca gttttgattc aagttggata
    44101 ttttaaggca acaagaaaga gattctttaa gatggctcca atacaccacc actttgaaca
    44161 gtgtggttgg ccagaaacaa gagttgtatt tattttttgg attataacag ttgttttagc
    44221 ttggataagt ataatagcag tattttaggg ctagggggaa tgaaaaatgg acttaaaagg
    44281 aaaaaaagtt ttattagtag gacttgcaaa aactggtata tctacaatta aacatttaga
    44341 taaattgggt gcaagtgtaa tcgtaaatga tataaaagat gaaaataaat tgagaaatat
    44401 acttgatgaa ttgaaatcta taaatgacat aaaatacata ttaggacatc acccagaaga
    44461 tgtagatgat atagatatgg ttgtagtgtc tccaggtgta ccactagacc taccattcat
    44521 attgaaatta aaaaattcag gcaagtatat aattggtgag gtagaattag cttttaaact
    44581 atcgaataat ccaattttta tagggattac aggtacaaat ggaaagacaa ctacaactag
    44641 tttggtagga gaaatttttt caagagcaaa acgagataca tatgtagttg gtaatatagg
    44701 aaatcctgta atagatacta tagaaacttc aagtgaagag tctgtgttag taactgaact
    44761 aagcagtttt cagcttgaga gtatagatga atttagacct aaagtaagcg caatattaaa
    44821 tattacagag gaccatttaa atagacacca tactatggaa aaatacatag aagcaaaggc
    44881 aaatatattt atgaaccaaa ctgttgagga tttctgtgta ttaaactatg atgatgagat
    44941 agtaaaatct ttagctgata aatgcaatgc caaagtaatt tacttttcaa gaactaaaaa
    45001 agtaaatgga ggagtatatt tagaaaataa tgacataata atagatatag atgataaaat
    45061 caaatttcta aataaagatg atgtaagttt acctggaggt cataacttag aaaattgtat
    45121 ggcagctata gcaatagcat atgtctgcaa aattgattta gaagttataa aggatgtact
    45181 tatgacattt aaaggagtgg aacacagaca agagtttgta agaaatttag acaatgtaat
    45241 atatgtaaat gattcaaagg gaactaatcc agattccact ataaaagcta tacagtctta
    45301 tgatagacct ataatactta tagcaggggg gatggataag ggaagtaatt ttgatgaact
    45361 tcttgaaact gcaaagtcat atgttaaatc attggtctta ttaggagaaa ctgcatcaaa
    45421 tatagaaaat tgtgctaaaa ataaaggatt taatgacata catatagtaa aagatatgga
    45481 agaagcagtt aagacttctt atgaaatttc aaaaagtgga gatatagtgc ttctttcacc
    45541 agcttgtgca agttgggata tgtatgaaag ttttgaagta agaggaaaag acttcaaaga
    45601 taatgtaaac aatttaaaat aatctcttac ctctaaactt acttaaatgg aagaatggag
    45661 gtagattagt tggatgccta aagaaaattt gaaaaaacaa attgacataa ggatgaagac
    45721 tgaatttgat ggagtagtgt tttacactac tatgctttta gtatttgtag gaatagttat
    45781 ggtgtttagt gcaagtttta tacaatcttc atttaaacac aatgatgcgt actattttct
    45841 aaaaaagaat gtaatatatg ctgtacttgg atttatagtt atgattatta catcaagaat
    45901 agattatagt ttttggaaga aaaatgctac agcaattgga gctatagcag tagtattatt
    45961 attgttagtt ttgacccctt tagggataga agcaaacgga gcaaaaagat ggttgggaat
    46021 aggagcttta acatttcaac ctgcagaaat cgcaaagttt gctacaataa tattaactgc
    46081 aaaattaatt gaaaaaaatt atgataaaat aaaatctttg acaaaaggtg ttgtaccact
    46141 tctcgtagtt ccagggatat tttttgcgtt gataatactt cagccaaatt tgtcaacagc
    46201 aggtactgta attctagtta cttttgtaat gatatttgtt gctggaatgg atatgaaaat
    46261 tgtatttgct atgataggga gtggggctgc tttatttgct gcattagtaa ttgctgaacc
    46321 ctatagactt agtcgtgtta catcattttt agaccctttt caagaccctc ttggtaaggg
    46381 gtatcaggta atacaaggtc tatatgcact aggttcaggt ggattgtttg gtctaggctt
    46441 aggaaagagt aaacaaaagt atttttatat accagagcca caaaatgact ttatatttgc
    46501 tataatagga gaagagttag gattgattgg ttgtataata gttattatgc tatttgtagt
    46561 tttagtctac agatgtgtaa gaatagcttt gaagacttct aatgtatttg cttgtatggt
    46621 tgttataggt ataggtgcac aaattggaat acaagcagct ttaaatatag cagttgcgac
    46681 atcatcaatg ccagctacag gtgtagcact accatttata agttatggag gaacttcact
    46741 caccatcttt atgggagctg taggaatagt gttaaacatc tcaaagcatg tcaaaattaa
    46801 ttaacaggag atgatgattt gatgaaagtt ttattatcag gcggtggaac tggagggcac
    46861 gtgtatccag ctatagctat tgcaaacaaa ataagagatg agcatccaga cgctgagata
    46921 atttttgttg ggacggaaaa gggaatagag tcagaaatag ttcctaagta tggatttgaa
    46981 ttaaagactg taacagttca aggctttaag cgaaaaatag atttcgataa tgtaaaaaga
    47041 gtttttaagc tttttaaagg tttggagcaa tcaagaaaga ttgttaagaa atttaaacca
    47101 gatatagtta taggaactgg tggatatgtt agtggacctg ttttatttaa tgcatctatg
    47161 gggaaaatac cagccataat acatgagcaa aattcttttc ctggtgtaac taataagatt
    47221 ttatctaaaa cagttacaaa ggtacttaca agttttgaag attcgcataa aagatttcca
    47281 gaggcagcag aagataaatt agtttttaca ggaaatccag ttagaaaaga aattttatta
    47341 tcaagaaaaa atattgcaag aaagaatcta tcaataagtg acgaaaaaag aatggtactt
    47401 tgctatggtg gtagtggagg ttcaagaaaa ataaatgatg caatgagact tgtaataaag
    47461 aatatggtaa atgaagatat agcttttata tttgctacag gcaaaagcta ttatgatgaa
    47521 tttatgggaa gtattagcga tataaatctt aaaccatacc aaaaagttgt gccttactta
    47581 gaagatatgg caaatgcact tgcagcaagt gatttggtta taggtagcgc aggagcaatt
    47641 tcattagctg agataacggc tcttggaaag ccatctataa taatacctaa agcttatact
    47701 gctgaaaatc atcaagagta taatgccaag agtatagaaa aacaaggggc aggaattgct
    47761 attttagaaa aaaatctaac tccagagagc ctaaatacag cagtatttaa acttttagga
    47821 gatagagaac ttttggttga tatggcaaat gcaagtaaaa ctataggtaa gcctgaagcc
    47881 atagacctta tatatgatga gataatgaaa gtatacaatt caacacaaaa gtcaacttct
    47941 aaaaaaacaa aaaaagaaaa agttattaag gaagtaaaag aaataaaaaa agaaacgact
    48001 ccaagtatag aaggtcaagc taaggtaata ggaataaaga aaagataagt aaatatttac
    48061 ccctaattta taatatatta gattttctaa attattataa attaggggtt tatttgtatg
    48121 tatacagatt taaatatata aatagtatgt agtatgctat gtttattttg atgaaatatt
    48181 gatttattta taaaatttaa taccttattt ggatgttatg taataaaatg caaaaatttg
    48241 actttaaata ttataatttt tttgtaggaa aaacaagctc taaaggtgta tttattaacc
    48301 aaaggggttg attatatttg aaaaaaagaa gaaagttaaa tacgaataat gtcatgatag
    48361 ttttagtttt tatacttatg ttatcttttt gtatatgtat aattgtaaaa agtgatttat
    48421 ttgatgtaaa gaaaatagat gtaattggaa ataagagggt gaccaaatca aatataatga
    48481 aagaactaaa tgtaaatcta aatgaaaata tttttgcata caattttaaa gatatgaaaa
    48541 ataaacttat aaaaaatcca tatatagaaa atgtggaaat aaaaagaaaa cttcccaata
    48601 agataattat aagtttaaaa gaaaaagaaa tatttgcagt attaaaagat gaagataatt
    48661 attgttatat agataaaaaa ggaaatttat tggaagaact aagaggttct aatgaaagta
    48721 aaaaagactt gatagtagat gtagattata gcattgatga taataaatct ataaaattta
    48781 aaaattataa aactaaggag aatgtattta aaactttaaa ttatttaaaa gaagaaggaa
    48841 tttatagaaa aataaattat gtaaacttaa aaaaagaaag caatatagaa atgcttacaa
    48901 gaagtaatat aaaaatctta ctttctaatg atgataactt agattataat atatctaggg
    48961 taagtaaaat tctgattgac ctgcaaaata aaaatactaa tggagggact ataaatctta
    49021 actatggaaa gttggcagtg tatagtccag aaggatagac aattgtaagg aagtgatata
    49081 ttgaaaaaaa gatttataaa taaaagtata atcataggaa gtattgtatt gggtgttctt
    49141 gttagtttac aacttaaaat tattaatata gaaaatagag ggatgacaac ttttaaaaga
    49201 ggagagcaac ttacagaaga acttaaatct ttaaaaaaag aaaaagagaa tctacaatca
    49261 gaagttaata gtgtgaagaa agatatagag atttatagag gcaaaaacaa tgaaggagaa
    49321 caagacatac ttaagtcaga aatagaaaaa tatgaaacat tagctggata tacagatgtt
    49381 gaaggaacag gcataaaaat tgagataaat tctacaaaag acttaggaaa ctctgataaa
    49441 aatgatagta tactatataa ttatgattta ttattatcaa tgataaataa attaaattca
    49501 gcacaagcaa gtgccatatc tataaacgac cagagaatag tttctaatac atatatgtat
    49561 ttaaaagaag acaagcttta tatgaatgac actgtcataa aagaaccaat tataataaaa
    49621 gcaattggtg attctgatac attggcttcg gcacttaata taaagtatgg tattgtctgg
    49681 gaaatagaaa catattataa tgccaaagta aaagtgacca aagaagacaa tatagaaata
    49741 aatggtcata gtgatataaa caaagcagag gggaaataat agtatgaaaa agaaaatagt
    49801 tatattagga gcattcatat taggcgtttt catatcaact tatataaaat cactagaccc
    49861 aaatagagta tacataacat taggtcaaac tgaaagtatt gaaagtgagg tagaaaatac
    49921 aaaaaaagaa ataaaaaact taaaagaaac tcttaaaaag aacaaaaaaa ctttgaatga
    49981 atataaagaa gcaaaaaaga atggaaatga atctatccaa acacttatgc aaaaagagct
    50041 tgaagaagtt aaagaattaa gtggttattc aactgttaca gggccaggca taactattac
    50101 tatgagggat agtgagagag agttaaaaga cggacagaat ccaaacgatt tgattataca
    50161 tgatatagat attttgaggg ttttaaatga tttaaaaaag gctggagcaa gagcaatttc
    50221 tataaatgga gaaagagtac tagcaacaag taagataaaa tgttcaggag ctactattac
    50281 agtaaatgat actacatatg gacaaccatt tataataaaa gctataggag atatagattt
    50341 attgagtgca gctataaact ctccagaatc atatgctaaa tctcttaagg atatatatgg
    50401 aattaatata aaagttcagg aaaataatgg aaataaagtg aatttatttg caaaataaaa
    50461 cgaaaaatac aaaaaaataa agaaaaagta aaaaaaatta ataaaaagga ttgtaatgta
    50521 gttgtgtttc aaagtaaaat aaagaggtga agatttatgt tatgggtttt aggaggatta
    50581 gcatttggtg tagtagtagg ttactatatt ccatttacat attctatgga ttattccata
    50641 tatatgtcag tagctattct tgcaataatg gattctattt ttggagcgat aaaatccaat
    50701 tttgaagata actatgataa tgtaattttt attactggtt tcataggtaa tgctatattg
    50761 gctatattat tgacttatat aggagaaaag ttaggagttt ctctttacta tgttgctgta
    50821 ttagtttttg gtatgagatt gtttaataac ttatctataa ttagacgata tattattagt
    50881 aatattatga acaaaaaacg taaaaattaa agagcattta atatatacgt aaattatttt
    50941 atacttaaag agtaatattt gacaatataa gtaagaaatt taaaaaggaa aatttacgtt
    51001 tttgtggaat atgttactta aaggttaaca aaataaaaga agaaaatgat ataattaata
    51061 catacgataa ctttgaatca tgagagaagg gggtttatga tgctaaactt tgacgtagaa
    51121 ttagaagaat gtgcacaaat taaagtaata ggtgtaggtg gcggtggaaa caatgctgtc
    51181 aatagaatgg tagaagctca actaaaaggc gttgaattta tatcagtaaa tacagataaa
    51241 caagctttat atacatcaaa agctgaatat aaagttcaaa taggagaaaa attaactaga
    51301 ggacttggag caggagcaaa tccagaagta gggaaaagag ctgctgagga gagtaaagat
    51361 gaaatagtaa agttacttca aggagctgat atggtctttg taacagccgg aatgggcggt
    51421 ggtactggta caggagctgc tccagtggtt gcaggcttgg caaaagaaat ggggatactt
    51481 acagtaggtg tagttaccaa accttttgca tttgaaggta agataagaat gaagaacgct
    51541 gaaggtggaa tagcagaact taaatcaaaa gtagatactc ttataacgat accaaatgat
    51601 agacttttac agatagtaca aaaaaataca tcaatgttag atgcttttgc agttgcagat
    51661 gatgtgttaa aacaaggtat acaatcaatt tcagacctta tagcagttga agggttaata
    51721 aacttggact ttgcagatgt tactactata atgaaagaca agggacttgc tcatatgggt
    51781 ataggtagtg ctagtggtga aactagagca attgatgctg caagacaagc tattcaatct
    51841 ccacttctag aaacatcaat acaaggagct aaaggagtac ttcttaatgt tacaggtggt
    51901 cctaacttag gattatttga agttaatgag gcatcaactt tagttatgga atcctgtgac
    51961 ccagaagcaa atgttatatt tggagcttct ataaaagaag atttaggtga tgaaataatg
    52021 attacagtaa tcgcgacagg atttgaagga ttacaaaatg gtgccttaga tttagatact
    52081 aaacctaaat caagcatacg ttcttcatta aatacaacag taaaacaagc tgtaaaagaa
    52141 attgaagaag aagtaattgc tgaggaaaaa atagagcctc ctaaaaaggc aagtataatt
    52201 gaagaagatg atgatgagag catggagata cctacattcc taagaagaag aagataatat
    52261 gtaagcttat aaagaagtca atagacttct ttttattttg ctcaatttag atagttagtt
    52321 tgtggctaga cttaaaaaaa tttttaaata ttgataaaat ttaaaaagta agtttttagt
    52381 atgaattaaa tctaataggt atagaaaaaa aatatagtta taggagttag tatagttttt
    52441 tatgattaga caagagtaat cttatttgtt aatattaaat ctgaattaaa tgtaaacatt
    52501 tgaggaaaaa gacaaattaa agtctgaaag gggattaagc atgattaaac taaaaaaggt
    52561 tctttcttta gttatggtag ggattctatc agtatcaatt cttgcaggat gttcaaaaaa
    52621 agaagattct aaaggcaaag agggtaaaga aaaattagtt gtatggtctg caccattaac
    52681 agaccatgat gcagatgcat ggaagccgat atttgaaaaa tttgaaaaag aaaataactg
    52741 tgaaattgaa tttcagatag taccatggga taactacgca gaaaaatatg caacagcaat
    52801 aagtgcaggt gaaggtccag atataggata catgtatgca gagatgtttc ctcaatttat
    52861 agaaatgggt gcggtagaag atttaacacc ttatttagaa aaatcaggaa cttcagataa
    52921 ttatctatac ttagatgatg caaaaatgat gggtggtatt tatggtttac ctatagaagc
    52981 tgctaatcca ggcgtattgt actacaataa agatatacta gaaaaattag gagaaaaacc
    53041 tccaaaaaca tgggatgatt ttaaaagaat ctgtgaaaaa gcaacaaaag atactgatgg
    53101 agatggaaaa atcgaccagt ggggtcttgc acaaggttgg ggttctaaag tatttggaag
    53161 cttaaactgg aactggtatc cgtatttatg gcaagctggt ggagatatat ataatgatga
    53221 tttaaaatca gttaaattta ataatgcaga aggcttgaaa gctgcaaact ttataaatga
    53281 tatgaaaaag tatattccag aagatgcttt atcaaaagat agtaatgaaa tgattgaaag
    53341 tgtatttgga ccaggaaaag ctgcatttac tataatgcta tcctctgctg ctacaagtac
    53401 atttgataaa tcattcccgg atttaaactg gggatatgta acatcattag aagataagac
    53461 agttggaagt tttgcttcag tagatgattt aacattaatg tcagcatgta aaaataaaga
    53521 acttggattt aaacttcttg agtatatgct aagcaaagaa tcaatggaag ctttccacaa
    53581 agaaatacct agagctccag ttgctaaagg tgaaaaatac caaggagacc caagatttga
    53641 agaaatggtg acaagagata aacatatgta tagaccattg acagttggac ctcatggagt
    53701 agagatatat gaatatttat ggaaacaact tcaaatgatg atagctggag acataactcc
    53761 agaacaagca ctaaatgaat ctgcaaaata tgcaaatgga ttactagcac aataatttat
    53821 atttgaattt acagactata taatttgatt ttatataagt aaaagattta cttgatatat
    53881 tattaaatta tgtagtcttt ttttgtaaat ataccaaaag tagagcgaat aacttctacc
    53941 tagatatatt ggattctaca aaaaagtcta tttgtttggc attaaaaaaa tatcttttga
    54001 cgacataaag tataagacat atatcattgt tctttttaaa tagaatttgt tttggattcg
    54061 accatcaaaa gtgacataaa attttgtaca tactatctta taatatgttt aaaggtttta
    54121 aggggggata catggtgtat attgagtact atgttataga aaacctagta ataaattata
    54181 ttattataag ttgtacttct attcttacta aaagatataa tcctaaaaaa aataagttat
    54241 tgggggctag tttaggaggt gcctattctg ttgcttattt gtatccatca atgaatatac
    54301 tatttactgt accatttaaa ataataatca tgagtataat aactttaatt tcatttagaa
    54361 gtaagagcaa aaaagattat gttcatgtag cgttagtttt ttatctagta aacattttta
    54421 tttctggaag cacttatttt ataatttatt ttacaggaat aagtcactta aaaatatctt
    54481 tcttaattgc atgtacttat gtgagttgtg aattattaaa atacatttat aaagatttga
    54541 aaatgcttaa gtacattaag gagcttacaa agactataaa tataaactta ctagaaaaaa
    54601 gtttttgctg taaggcttta gtagatagtg gtaatttgtt aaaagaccca ataagtcaaa
    54661 gtgatgtaat aatagttaag tctagtgtgt tagaaggatt tattccagaa aaactattaa
    54721 atattaatta tgaagatata gatatgaaga aagcacaaga aattatagga agtttagatg
    54781 ataaaacttc aggtagagtt agaataatac cttataaaca tgctggaagt aataagacaa
    54841 gcataataat aggcttaaaa gctgactata tagaagtaga tgagcaaaag ataggaaata
    54901 taatacttgg tatttcaaat tttaatgata gagaatatgg agcaataatg aatccaaata
    54961 tattgcctgg attttaggtg aaaatttaag ggggacaagg aatgttacga ttgaaagaaa
    55021 gaataataag ctttattact atgttaggta ttaaattaaa aataataaag ccaaagggaa
    55081 tatactatat gggaggggca aatatacttc ctcctccatt gaaaccagaa gaagaaatgg
    55141 agcttttaca aaagctagaa acagatgaaa gtgtaaagtc aattttaata gaaagaaatc
    55201 ttagattagt agtctacata tcgagaaaat ttgaaaatac aggtatagat gtagaagatt
    55261 tgatttcaat aggaactata ggtttgataa aagcagttaa tacttttaaa ctgaataaaa
    55321 atataaaatt ggcaacttat gcttcgagat gtatagaaaa tgaaatatta atgtacttaa
    55381 gaaaaaataa taaaaagaaa acagaagtat catttgatga acctttaaat atagatttag
    55441 atggaaacga acttttatta tctgatgtat tgggtacaga aaatgatgaa atatacaaaa
    55501 taattgaaga agaaatagat agagatttgt tggttatggc acttgacaga ttaagtgaca
    55561 gagaaaagca aattatggaa ttaagatttg gtcttattga taaaggtatt gaaaaaacac
    55621 aaaaagaagt tgctggaatg cttggaatat cacagtccta catatctaga cttgaaaaga
    55681 aaataatctc aaggttgcaa aaagaaatga aaaaatttgt ataatgctaa attaattctt
    55741 cttaaaaagt ataaaaaaat tggaaatgta aataatttca atagatgaat acttttgaga
    55801 gaggactgaa aatatatgca agttaataag gttgaaatat gtggtgttaa tacatcagaa
    55861 cttccagttc ttaaaaataa gcaaatgaag gaacttttat tacaaataaa aaatggtgat
    55921 gaagaagcca gacaacagtt tgtaagaggg aatttaagat tagtcttgag tgtaataaaa
    55981 aagtttaaca acagaggaga aaatatagac gatttatttc aaataggttg tattggtctt
    56041 ataaaagcga tagataactt tgatttaagc caaaatgtaa ggttttcaac ttatgctgtt
    56101 cctatgatta taggagaaat tagaaggtat ctaagagaca ataacccaat tagagtaagt
    56161 aggtcattaa aagatatagc atataaggca ctacaagtta gagaaagatt aattagaaca
    56221 aattctaaag aacctacagt atcagaaata gcaaaggaat tagaattaga agtagaatca
    56281 gttgtaatgg cacttgatgc catacaagac ccaatatctc tgtttgaccc agtatatcaa
    56341 gacaatggag atgcaatatt cgttatggat caggttcaag ataaaaaaga tactgatgaa
    56401 aattggttgc aagaaatatc acttaaagaa gctattaaga aattaaatag tagagaaaag
    56461 ttggtattag atttaaggtt ttacaaagga agaactcaga tagaagttgc tgatgaaatc
    56521 ggtatatctc aagcacaagt atcaagaatt gaaaaaaatg ctttaaagaa tatgagaaaa
    56581 tatgtataag taatccatgg actgtaaaca ttattttaat ttaaatgacc tatataggtc
    56641 attttttttt acttcgatac atatttattt ttaaagaaag ggtgagtaca atatgattag
    56701 agtttctgat ataatggaaa aagaaattat aaatgtaaaa aatggaaaaa ggatggggtt
    56761 tataatagac atagacatgg atattcacga aggtaaggta gtctcattta ccatttttgg
    56821 agatggaagt agaagttttt tttcaagagg aggggatgaa gaagttatat tttggaatga
    56881 tatacttaaa ataggttgtg atacaataat agtaaatata ggttcagaat taagcttaga
    56941 tgagtttgag atatagttaa acaaaggagg aatatagatg caatgtcctt attgtaatta
    57001 taaagaatca aaggtaatag attctagaca tacagattta aaatctatca gaagaagacg
    57061 tgagtgtgaa tcatgtaaaa agaggtttac tacgtatgag aaaatagaaa caactccttt
    57121 aatggtcatt aaaaaggata atagtagaga atattttgat agagaaaaga taaaatatgg
    57181 attgctaaaa gcatgtgaaa aaagacctgt ttctattgac gagattgaaa gtattgttgt
    57241 acatattgaa aatgaaataa ataaatgttt tatagaagaa attgaaacca aaaaaatcgg
    57301 tgagatggta atggataaat tgaaagagtt agatgaggtt gcctatgtaa gatttgcttc
    57361 tgtgtataga caatttaaag atataaatac ttttgtaaat gaacttaaaa gtatactgat
    57421 agaaaaagga gacaaatgat gaaagattat ataaatataa aaaatgtaca agatattaaa
    57481 gagtatgtta atttaagtgg taattgtgaa gaacttgatg aaaaattaaa ttctgtaaat
    57541 ctagttataa catgtaagaa tatagatgca aaaaatagag aagatatgtt aaaagtatgt
    57601 aaagaatgtg atttgacatt tgaaaatcta actagtaatt ctcaaataca ttcagatata
    57661 gttaatatag tcaataaaga tactataggg aaaagaagag atggagatgc acttataaca
    57721 aacttggaaa aagtaccact tttactgttt acagcagact gtgtacctat atcaattata
    57781 gatgctaaaa ataaagccat aggactggct catgcaggtt ggagagggac ttttagtaat
    57841 ataggtcata aaacaataaa attaatgtct gaatgctata aaacagttcc tgaagattta
    57901 gtatgtataa ttgggccatc aattggacca tgttgttatg aagtgtctga agatttagta
    57961 gaaaaattta acacaattct tacaaataat gatgaaaagt tctatataat aaaagaggga
    58021 agttactatt tagatttatg gaaaattaat gagtatatgc ttagatgtag tggagttaaa
    58081 aaagaaaata taataaattt aaatttatgc actagttgta gagcagataa attccactct
    58141 tatagaaaac ataataaggc atcagaacga ataggaacgg tactacagat aaaatagaga
    58201 ggagcttttt aatgaatact aaagtgcttg ttatagacga tgaaatgcat atagttgagc
    58261 tattaaaatt caatttggag gtgtcaaatt acgaagttag ttattcatat gatggatttg
    58321 acggatttat aaaggctaag gaaattaaac cagatttaat acttttagat tggatgttac
    58381 caaatataag tggaatagaa gttttgagaa aaataagaag tgataaggac ttaaaaaata
    58441 ttcctgttat aatgcttact gctaaaaata tggaaaatga caaggttgaa gggcttgaaa
    58501 taggtgctga tgactatata actaagccat ttagtataaa agagttgtta gctaggatta
    58561 gttctgtttt aaggagatat aatttgacta gcttaggtga agaaaacaat atacttacta
    58621 caggtaattt aaaactagat ttatcaaaac atgaagttac caaaggctct gaaaagatag
    58681 agttaactct taaggaattt gaattgttaa aattattaat tcaaaataaa ggaaaagtac
    58741 tttcaagaaa ttatcttttg gataaaatat gggggtatga atactatgga gaaactagaa
    58801 cagtagatgt tcatataaga tatttaagaa aaaaaataga agatgaagat aaatcggaaa
    58861 aatatataga gactataaga ggtgtaggat acaaaataga ttaaaaaggt tatattttag
    58921 gagtgttatc ttgtggaaga tttaaatagt atatattttt ttattgttat gttgtccata
    58981 gccattgtta tattagctgt aagatacaca ataacattaa ggaaatattt aaaagagttt
    59041 atatacgtct caaaaaaagt aagtaataat gaatatcatg ctaggcttaa catatcagcc
    59101 aaaggagaac ttggcgaatt agctagaaat tttaatcata tgataaagaa tatggataaa
    59161 accttagaag aagtacagta taaacattta cagctaaggt ctatattaaa gagtatatct
    59221 catggaattt tagctataga tgtaaatgga aatatacttc tgataaatga tgaagcaaaa
    59281 gaaatgataa agagtgaacc aaatcaatta gttgaaggtc ataatattaa tgttgtaata
    59341 aaagaagaag aaatattaaa acaaatactt caatttattg gttctaaaga taatgaaact
    59401 gctaatatta ctactaaaga tgatatcgta tataagataa aagtagaccc agtttatctt
    59461 cagaatacta acaacgtaat aataggttcg atagtaaata tagaagatat tactaaaaaa
    59521 gttaaacttg aaaatatgag aagtgatttt gttgcaaatg taagtcatga acttaaaaca
    59581 ccacttacat ctataagtgg gtttgttgaa acactaaagt caaatgaaaa tatagatgtg
    59641 aatactagaa atagattctt agaaataata gaaagcgaat cagatagatt aaaaaggttg
    59701 attgatgata tattgctgtt atcatttgta gaaaataaag atactcttct tatggaaaat
    59761 gttgtagtat atgatgtatt taaagaggta tatgaaataa ctcaacattc agctagtgaa
    59821 aaaaatatag aagttttata taaatgtgat gataaatcaa taagtatact atccaataaa
    59881 gactatataa agcaagtgtt cttaaaccta gttgataatg ctataaagta tacccaagat
    59941 aatgggattg tacaagttgt agtgttaaaa gatgaagaaa aaatcgtaat taaagttata
    60001 gacaatggtg tagggatacc aaaagaagat gtagaacgca tatttgaacg attttatagg
    60061 gtagataaag caagaagtag ggatgtagga ggaacgggtt taggattggc tataacaaag
    60121 catatagtca aatcactaaa tggatgtata aaagtaaaaa gtgaacttgg cattggtagc
    60181 gaatttatag ttacaatatt acaaaaaaat ttccttaaat agaagggaat tttttttgtt
    60241 ttttgcacaa actatataag agaaggagct gagaaaatgg aagaaagttt attgaatgca
    60301 aatttattta gacactcttt tatagttgca ttagttgtag gaatattatg tagaggatta
    60361 gttttaagag ttacagacaa acaataccca tcaagaccac aagattattt agaacagata
    60421 attatatctg ggctttcagc ttcgttaggt gctatagcat tacctgcact tatagataag
    60481 gagtttgcag ccttgacatt ttttgcagta gcaatacaac agtttcaagg tcttgcagaa
    60541 caagaaagaa taacactaaa gaatatcgat aatgaagaat tagtaccaaa aggagacgct
    60601 tacgttgaag aaatagcatc tacgtatgaa tctagaagtt atataagtct tttttctgca
    60661 ctggtatctt cgatagttta tatcgttttt gcaagaaagt atggccttag ctttttttat
    60721 tgcacaatcc tagctattgt gtcaggagct attgttggtt tgatttttag aagattttta
    60781 agaaggaaca gtatagcaga tatagcagat atagttcctg caaaaataag ttttgaagga
    60841 cctattttaa tggtaaatgg tgtaataata actaacatag gtctagaaag tacaagagaa
    60901 aagtatagaa atgaatgtct ggccatagaa gttataccaa gagatttagg tgcatttgga
    60961 atagtaaatg atatagggca aagacaagct ataatacata atctatttat tcatatgggg
    61021 atagatagag atgtagatga ggttgatatt gttgctatat ctaagaccaa tttagaaaaa
    61081 agtactgtgg ttataccata tatgccaata ctcaaagata tagatgtcat gatagatgta
    61141 gtgaaaagta cacctatcat agaaacatca aaaggaaagc agagtgattt ttctagaaag
    61201 actttgtaga tttacatgta aaatttcaaa ttaaatattt taggagtgat ttaatggata
    61261 gagtattttt tgttgctgtt attattggta taacatctag aattataatg ttgaatttag
    61321 accaaaaaca gtatccaacg caaccaaatg ttttactatc tcaacttata ttagcattcg
    61381 tcgcttcttc attaggagca ttattggttc cagctcttat aaatcgttct tatacatcta
    61441 taactttttt atccctagca gcagagcaat ttagacaagt gagagcaaat agaagaaata
    61501 cattgcaaaa cttagaggaa gttcaacttg taaagagagg agctgcattc atagaagaga
    61561 tagctagaac ctatgaagta agaaattata tgtgtatagt tacatctttt ttaacaatag
    61621 gattgtatta tgtaatactt gcagaaacga aaataagtga aggaatgagt ttggtaataa
    61681 gttcaatttg tggattagtg ttagccttta tattaaaaaa acttcttact agaaaaagta
    61741 ttggagacat agctgatgta atgcctgctg agattagttt tgtagatgag tctatattga
    61801 aggtaggaga tttaaaggga ataacaaata taggtctaaa aagtgataga gaagtatata
    61861 ttaatagagg tgtaggaata caaataattc ctaaaaataa agattatgct aatgcaggga
    61921 tattatttga ctcaggtcaa agacaggcaa tagtatacaa tatatattca aggttaggtt
    61981 tatatggaga ttatggagaa ccttcattcg taccattacc tagaaggaat aaagaggatg
    62041 aaagtataat gattgcttat ttaccagtag ataagaatgt ggaaaaagta atggaagccg
    62101 taaagtcatg cccaatactt tcaagttcta aaggaaaaaa cttatcacta aaaaattata
    62161 aaataggaaa gaaaggaagt gcataagatg ggaatggata taggtttaaa tgaatatacc
    62221 ctagctatag ttacacttga taagaatatg aaaaatggtg gaggttgtcc aatattttat
    62281 gcaaatgatg agaaagactt acaaaataag gcattgttga tgtcaaagtg tgtaggtgga
    62341 atggttcatg atatgacaaa tgggacgtta atcatagtaa aacattaaat ttataaaatt
    62401 tttttaagaa caaataatat tcaaattttt aagaaactta aatttgaata ttatttgttc
    62461 taatctattt tatagctatt tacttatatt gactattaga attaaaatgt gttattatga
    62521 catgaaatgc ttaaaaatgc tatcataaaa tataataaat aaataaattg catattaaaa
    62581 tatattataa taagcattga tgaatacaaa agagtggtga aaatattgga agtaaatgta
    62641 aaaaaagtaa ataatattat aagtaaggtt tataaagata gtattgcaga agaaataggt
    62701 atagaggtag gagatttact tatatctgtg aatgaacagc caatacatga tataatagag
    62761 tatagattct tactaagtga tgaatattta gatgtagaaa tacaaaaaaa agatggcgaa
    62821 gtctacatat acgagataga aaaagactat gatgaagatt tgggtgttga atttacaaat
    62881 ccgataattg accaagctaa aagctgtaga aataagtgta tgttttgttt tatagaccaa
    62941 ttgccagaag gtatgagaga aactctttat tttaaagatg atgattcgag attatctttt
    63001 ttacaaggaa attttgtcac acttacaaat atgagtgaag aagatataaa taatattata
    63061 aaatatagaa taagtcctat aaatatatct gtgcatacaa ctaatccaga gttaagacaa
    63121 aaaatgataa gcaataaatt tgcaggaaaa ttatatggta taatgaagag attggcagat
    63181 actcatatag aaatgaactg tcaaattgtt ttatgtccag gtataaatga tggaaaggaa
    63241 ttggatagaa caataaaaga actagctcaa ctttatccgt atgtaaacag tgttgcgata
    63301 gttccagttg ggattacaaa gcatagagaa aatctagtag aattaaatat atttaatgat
    63361 aagagcgcaa gtaaaactat agagcaaata catcaaatac aacagaaata tcttgaaaaa
    63421 ttaggtactc gatttgcatt tttatcagat gaattttata tactatctaa tagtgaattg
    63481 cctggatatg aagaatatga aggtttttta cagtttgaag atggtgtagg tatgatacgt
    63541 aagttaaaaa cagagattga agagtatcta aatatattgc ctgagaagat tctaaaaaga
    63601 gagaagaaag tatcaatagc tactggtcat tctgcatatg aatttataca gagtatggca
    63661 gatgctatga tggacaagtt taaaaatctt caagtaaatg tatatgaaat caaaaacaag
    63721 ttttttggag agacaataac tgtatcaggt cttttaacag ctaaggattt aaaagaacaa
    63781 cttgaagata aagaattagg agaagctctt tatataacaa gaagtatgct aaaagcagat
    63841 gaagaaattt tcttagataa tattgaatta aatcaattag aagaacttat gagaataaaa
    63901 attatccctt gtttgaatga aggaaaagat tttgtggata aaattttaaa atagaaaaca
    63961 aaagatggaa ggagaaataa aatgagtata agtaggccag ttgtagctgt agttgggaga
    64021 ccaaacgttg gtaagtctac aatatttaat aaatttgcag gaaaaaggat atcaatagtt
    64081 gaaaatacac ctggagttac aagagataga atatttgctg aagtagaatg gttagataaa
    64141 tattttacat tagtggatac aggaggaatt gaacctgata gcgaagatat aatattatct
    64201 caaatgagaa atcaagccat gcttgcaatg gacatgtcac atgtaatact ttttatagtt
    64261 gatggtaaag ctggaataac agctgctgat aaagaaattg cacaattgct tagaaagaca
    64321 aaaaaaccag taatcttagt ggttaataag attgatagtc aaagtcaatt tgataatata
    64381 tacgattttt atgagttggg atttggaacg ccttttgcag tttcaggagc caatagtatg
    64441 ggatttggag atttattaga tgagatagtt gaaaattttc cagcaggatt agatacagag
    64501 tatgaagaag atataataag agtagctata acaggtaaac caaatgcagg aaaaagttct
    64561 atactcaata agatacttgg agaagaaaga gtaattgtaa gtccaattgc aggaactact
    64621 agagacgcaa ttgatactta ttttgaaaaa aatggacaga aatttcttct aatagataca
    64681 gcagggctta gaagaaaaag taaaatatat gagacaatag aaaaatacag tgtaataaga
    64741 gctatgagtg ctgtagatag agcagatgta gtattgatag taatagatgc cttagaaggt
    64801 gtaacagaac aagatacaaa ggttgcaggt atagcacatg atgaaggaaa aggatgcata
    64861 tttgtaatca ataaatggga tttaatagag aaagataata agactatgag taattacaca
    64921 aaagatataa aagaaaaatt tccatttatg atgtatgctc caatcgtatt tgtttctgca
    64981 aaaactaatc aaagaatgaa caagatacta gatacagttg aatatgtgtc aaatgaacat
    65041 tctaagagaa tatcaacttc agcactgaat gaagtaattg gagaagctgt aatgttaaat
    65101 caaccaccat ctgacaaagg tagaagatta aaaatttact atgggactca aactgacatt
    65161 agacctccta aaattacatt gtttataaat gataaggatt taactcactt ctcatatcaa
    65221 agataccttg agaataagat aagagaaaat tttggatttg aaggaacttc cataaagttt
    65281 gagtatagac aaaaaaataa aaaataaata tcttaaaata taactaaagg ggggaaattc
    65341 agtggagata tttagttata taattattgc tgtagttgca tatcttttag gaaatatatc
    65401 tacctcatac atagttgcaa agcgaattgc tggggttgat ataaggactc aaggttctgg
    65461 taatgcaggt tcgacaaatg tacttaggac acttggaaaa agagcaggag caatgacatt
    65521 tttaggtgat gttcttaaag gtgtaatggc tgttttaata tcagaatttg cagcaagatt
    65581 ggttggaata gatactcttt tagctggata tctggcagtt atatgtgttg tagcaggtca
    65641 taattggcca gcggttttag gatttagagg aggcaaaggt gttgcaactt cactaggggc
    65701 aatgctagct gtaaatccag taataacact aatgtgtcta gcagtattta tattggtggt
    65761 agctataaca aagtatgttt cattgggttc tgttgtagga ataggatgtt caccaatatt
    65821 tatgattatg gtaaaaaata aagctggttt aatagtagct ctgttcttaa ctgcatcagt
    65881 aatatataat cacagagcaa atataaagcg attattaaat gggacagaga gaaaaattgg
    65941 tcaaaagaaa gaatagtaaa tatattatac tcaggtggtg ttaaacatgg agaaagtatg
    66001 tgtattaggt actggaagct ggggaagtgc attagcttta gggcttgcaa aaaaaggtaa
    66061 tgatgtgagc atgtggactc gaaaagagga acaagctaaa aaaataaaca gaactaaaga
    66121 aaatacagac tatttaccag gagtattatt tccaaataat ataactataa gtactgatat
    66181 agaaaaaact ataaaagatt gtaaggtaat agttttagca gttccatcac aggctgtaag
    66241 aagtacttgc caaaaaataa aaccatttat aaaagaagga caagttattg ttaatgtagc
    66301 taaaggtctt gaaaaaggga ctgggcttag attatcacaa gtctgtgaag aagaattacc
    66361 acaaaatcca tatgtaatac tatctgggcc atctcatgct gaagaagtag caagggatat
    66421 tcctactacc gtagtagttg cttctaaaga tttaaaaata gcacagatga tacaagattt
    66481 gtttatgagc cctaaactta gagtttatac gaatccagac atagttggag tagaacttgg
    66541 aggagcatta aaaaatatta tagcatttgg agctgggata tgtgacggat tagggtatgg
    66601 tgataatgca aaagctgccc ttatgacaag aggtattagt gaaatgagca gacttggaat
    66661 tgctatggga gctaatatgt ctacctttgc aggtctttca ggtattggag atttaatagt
    66721 tacttgtaca agtatgcata gtagaaatag aagagctggt atactcatag gtaaagggat
    66781 gagtttagaa gatactttaa aagaagtaaa gatggttgta gaaggcataa ctgctactga
    66841 agtagcacat gatgttgctg aaaaattaga tatagatatg cctataacta atgctatata
    66901 ttctgtaata aagaaaggtt caaatcctaa agaagttgga atagaactaa tgatgagaag
    66961 taaaaagcat gaaatggaag aagtagtttt aggtgatgat atataaacta ttgtataata
    67021 aataataaat ttattttagg ggtgtctcaa aatgaacttt ttagtttacg aggcactcat
    67081 ttttatatga aattaaatat atttttatta tttcaacaat aaaaaaggct tatctctatt
    67141 ttgagacagc catattttaa ttttatttag catgttttat tatgtattca atagaagaaa
    67201 tcattttcat agttaattca tcatcatcag aattttttcc tgtgttcttt tttaagaata
    67261 atagattttg ataaaaagaa ataattatat cattgattat gtctaaatct ttagctggta
    67321 tatatccagt atctacaaga ttgtttaata gtatcttatt tctttccttt atactttctc
    67381 ctgtaatcat taaagatatg tcactatcat gaatacctaa atcttctgga aacatatcat
    67441 aatattgttt tgttatatag ctaagttcat cactagacaa gttaaaaaat acctggtaaa
    67501 aagcttgagc attatcaaaa gaatgcttac aaaataattt ccacataatt atatatttct
    67561 tatattcatc attgacattt tctatacatc ttgaaatatt caagttataa tctttaaaat
    67621 attttataga tgcaaatgat attaaatggt ctaaattttt aaagtattta tatagagttg
    67681 aactattata gccagccata tctgcaacct tacgaagtgt aatattttct ataccttcgt
    67741 tttccataat attttgagca gcttctatga aatacatcaa tatccttttc ttttgtaatt
    67801 ctttatttgt cattttattc acctacaaat aatcaatata gtttatataa tcgtgatttt
    67861 atcattaaac ttaccataaa tcaagaataa tattacaaaa tacaatgtat actcgttata
    67921 ttttagataa tttaaaatca ctagaatata aaaaattttt taaaataaaa tcatgattga
    67981 caaaataatc atgattatga taaaataatc acaaataaaa ttaatttaca tacaaatacg
    68041 acaagtacta aaaatattaa gaattttaaa ataatatatt catccttgtt gtattgaata
    68101 aattatctga atattaagaa agaggtgcat tatgtcaaat aatatgagac tagaaagatt
    68161 gagaaagtac atgaatgaaa aaagcattga aattgcttta atatttgaac cagacaatca
    68221 attttatatt agtggattta aagcaataac ttattctaga ccaattgtaa cagtagtaac
    68281 tcaagataaa atagaattaa tagtacctgg attagaagaa ttacatgcta aagaagttgc
    68341 aaaagttgat aatgtatatg tgtattatga aataccagaa atgaaagaac atggaatatc
    68401 acataaacat tacttagata taattttaaa taaataccct aaaggaacaa ctgttggaat
    68461 agaaaaagat atagtatctg caagcttttc agagtatata actgataagt catttgctat
    68521 caaagatgtt ggaagtaaaa tatttgaaat gagatatgta aaagatgcaa aagaaataga
    68581 atttttgaag atagcaggtt acctatctga tataggaata aaagggtctt tagaaaatgt
    68641 tagagttggg atgagtgaat tggagtttga cgttgaaggg gataatgctt tactaaaata
    68701 tgtttctgaa aattatcctg atacatatat aggatttgca aactggactt gttcagggat
    68761 tgatagaaca gcacaacctc atttagattc taatactaga atacttcaaa gaggagatat
    68821 agtaatacat agtagacagg tttggtatga aaactataga gcagaaaatg aaagaacttt
    68881 tattataggc aaaccaacag aaagacaaaa agaagtgttt aagattgcag tagaggctca
    68941 acaagctgga ttagatacaa taaaagctgg tataccagca agaatggtgg atgaagcagc
    69001 aagagctgtt gttgcaaagt atggtctaga gttatattca aatcatagaa ttggtcatgg
    69061 tttaggtttg tcagaacatg aagagccata tttaagattt gacaatgaat taatattaga
    69121 agaaggaatg gtattttcta tggaaccagg gatatatata cctggagttg gaggatttag
    69181 acactcagat acagcaatag taggtaagaa tggtgctaca attataacta attatccaag
    69241 aagtgttgaa gaacttatac ttgatattta aatcaataca tagtgtatga gtttgaataa
    69301 atttgaaatt ggaggaatta cagtgaaaaa gaaaattgga ttttgggatt tagtatttat
    69361 gaatatatca gcactatttg ggattagatg gatagctaaa tctactgcct ctagttttgg
    69421 attgggtctt ggttctatac cagtttggtt attgtttgct tttatattct ttgttcctgc
    69481 atcacttata tgtgcagagt tggctgcaac atatccaaaa gatggtggac ttggagaatg
    69541 ggttaaacaa gcttatggag agaagtgggg atttatggtg tcatggctaa attggacatc
    69601 aaagatattt tggtattctt ctttcttgac atttttagct ataaatattg catatatgct
    69661 tggaaatcca gatttatcaa acaataagat gtttatttta gcactttcac tcataatatt
    69721 ttggctgttg tccttagtaa gtactcgtgg gatggcattt ggaaaatttt ttacgaatac
    69781 aggagcatta ggttctacaa ttcctgctat attacttata gtgatggcat ttatgtctgt
    69841 agttattctc aaaaaagctc catcagcatc gatatataca atccaaaata taataccaaa
    69901 aatagatgcc aattcattag tttctatatc tgctataata tttgcattat caggagctga
    69961 aacgactgct aatttcataa ccgaaatgga taatgctaag aaaaactttc ctaaagctat
    70021 attaactgtg gctgttttaa taggaggaat ctatatctta ggttcagtag caataacaat
    70081 gatacttcct ccagataaaa ttgcagcatc tacagggata ctagatgcat tagctaaagt
    70141 tgcacaagat ttaggtatag gaagttggtt tataagaata gtagcatttg gaataacttt
    70201 atcagtacta ggagcattaa tactttatat agcaggtcca gtaaagatgc tttttggaaa
    70261 tgtaagagaa ggtgtatttc ctaagcaatt gactgttaca aataaataca atataccatc
    70321 aaatgcagta atagttcagg ctataatagt gagtctactt cttgtaggaa caaacttatt
    70381 accatcagta gataatatat acaatgttct tgttactatg acagcattaa cagcattatt
    70441 tccatatgtc ttgcttttta catcttatat tagacttaga aagacaagac caaatgaaga
    70501 aagaccatat tcaattgcaa aaagtgattc agtttgtatc aatattgcca gaatggtact
    70561 tgtagtaact gtagttggca tacttttctc aacggcacca gttatggaga ctttaaaaga
    70621 taatataatc tatgagattg aaatgatagg aggaggtctt tttgttataa taacaggttt
    70681 aatgctatgg aagaactatg aaaaaaagat atctaataac tctggacgtt agtataaata
    70741 aaaatataat tattatggtg agctaaaaga gtttactttt agctcataac tcaccataaa
    70801 ttattgatag attaacctaa tatattaata aatattccga aatattgaat aaacaataca
    70861 ataagcaata attaattatc atgaaaattt acaggtattt acataaggag gaagtatgtc
    70921 agttgaagta aataaaccaa gcatttggaa aaatttcaaa gtcttgataa tactctttgt
    70981 agcaggagca tttatatatg ctttaccata tttaaagaat tattattatg atacttttgc
    71041 acaagcattt aatcttacaa atacacaaat gggaagctta ggaagtattt atggtctact
    71101 tgcaatggta tcataccttt ttggtggttt tttagcagac cgtatttcag ccagaaaatt
    71161 gctttcaggt tctttaatta ttacaggaat atctggtctt gtattaacac tttatcctcc
    71221 atatattgtt gtgtttttaa tccatgcctt atggggaata acaacaatac ttactttttg
    71281 gccagctctt gtaaaagctg ttagaatgtt agcatctgaa aatgaacaag gaaaagcttt
    71341 tggatttatg gaaagtggtc gtggaattac caatgcaatt catctatctc tagtattgat
    71401 actatttggg tatatttcat caaaagtaag tgataaatct ggtcttacag ctattatagt
    71461 attatactcg gcaataaatg taatagttgg agtattagta tttttcaaat taaaggataa
    71521 tgaaaaagag gtatcagcaa aatttgataa agaagccttt tttgcagtaa taaaaatgcc
    71581 tcatacatgg ataataacaa taataatgtt ttgttcatat tcagctaata tgtcatttta
    71641 ttattttacg ccttattcaa ctgaagcatt tggagctact gtggtgtttg catctgcaat
    71701 ctcaatatta gctcagtatt gtagaccagt agcatcagct gcttctggat tacttggaga
    71761 taaagttggt tcatcaaaga ttatatctta tggatttata cttatgattg caggtctttt
    71821 aggtgtaata tttacaccaa caaaatcatc tatgatttat atactattga ttggatgtgt
    71881 tgcaatatat gtatctatgt atgcaattca aggtttacac tattcgttac ttgaagaagg
    71941 taattattca ttatcaatat caggaactgc tataggaata gttgctacat taggatatct
    72001 tccagaagta ctttgtcctt tagcagcagg gaagatattg gatgcatttc cgggtgtaac
    72061 tggatatagg tactacttca tagttcttac tatagtagcc ataattggat tggtgtttac
    72121 atttatatgg atgaacatga caaaagaaag acgtaaagaa cttattgaga tgaataataa
    72181 ttcaaatgaa aatactacta aagtcagtta atataataca ctactatttg gaccagcaat
    72241 attaatttaa tttacattga aatttacaaa tttctatatg taaattaaat taatattgct
    72301 ggtctttatt tttctatttt aagaatatta acccttaact ctaaatataa tttaataaga
    72361 ttagatgtat aggaggaata atatgaataa taacatatac gaagatatat ccaaaaggac
    72421 tcagggggat atatatattg gagtagttgg acctgtaaga acaggaaaat caacttttat
    72481 aagaaaattt atggaaaagt tggttatacc taatatagac aatgaattta aaaaggatag
    72541 aacaagagat gagatacccc aaagtggttc aggtaaaacg ataatgacag tggaaccaaa
    72601 atttgtacca gcagatggtg tagaaataaa aataaaagac acagtatctt taaaagtaag
    72661 aatggtagat tgtgttggat acatagttga aggagcttta gggcatgagg aaggtggaaa
    72721 acaaagatta gtatccactc cttggtcaca agaagctatg acatttgaaa aggcagcaga
    72781 gataggaact aaaaaagtta taaaagacca ttctacaata gggatagttg tcttgacaga
    72841 tggttcagtt actggaattg acagaaaaag ctatgtagaa ccagaagaga gagttataca
    72901 agaattgaaa aatcttaaaa aaccatttgc agtggtttta aatacgttaa gtccaaaaag
    72961 tgaggaaacg agtatgctta gaagtgaatt ggaagaaaag tatgaagttc cagttcttcc
    73021 aatgaatgtg gttgaaatgg aagaagaaga tatagaggag gttatggaag ctgtattata
    73081 tgattttcca cttacagaaa taagaatcaa cttaccaaaa tgggttgaag gtcttgaaag
    73141 aaatcattgg ataaaaagta gcataataac aacattaaaa caaagtatta tagatatagg
    73201 taaaataagg gatatagaag gtattataca aggattttct gagttagagt ttttggaaga
    73261 tacaggtgtt gataatgtag agctaggaga aggtgttata aatattgatt tacagacaaa
    73321 gcaagattta ttctataatg tccttgaaga aaaaagtgga tttaaaattg aaggagatta
    73381 tcaactgctt agtctgataa ctagactatc taaagttaaa aatgagtatg ataaaataga
    73441 aagtgcttta atagatgcca agataaaagg atatggagta gtagctcctt ccttagaaga
    73501 acttagtctg gaagaaccag aaataatgaa acaaggaaaa caatatggta tcaagttaaa
    73561 agccaatgca ccatcacttc atattataaa agcagatata tctacagagg tttctccaat
    73621 agttggaaat caaaatcaag gtgaagagat gataaaatat cttatggaag tatttgaaga
    73681 gcaaccagca gatttatggg aatcaaatat gtttggtaaa tcactacatg acttagtaaa
    73741 agagcaatta caaagtaaat tatatactat gccagaagag ataagagtta aaatgcaaaa
    73801 gactttacaa aaaattgtaa atgaaggaag ttctaatatt ataactattt tgttataaaa
    73861 atatagctac ttattaaagt gaaacgtctg tttgctttag taagtagctt tttatttata
    73921 acaattaata aagatactta tataaattga caataattga taattgtgga aaaattatag
    73981 tgggtgaagt atatgtttcg acaggattgt ttcaaagcta aaaatttcta ggagtgtaag
    74041 atgaaaaagt atgagatatt tatttttatg agtataatag ttttgtgttt tataagtttt
    74101 ccacataaag tttttggaca agaggaaaat tgtcttgaag attttgaaag gtgggttcaa
    74161 gaaaataaaa ataataaaga agaaatagtt tatactcttt cttgtgatat ggtaatagat
    74221 gaagagttta gattttatat tccttatgac agtaatttta caatagatac caacaaatat
    74281 aaaatattga taaaaaatca tgggagattt attattgatg ataatgaatt gaatataata
    74341 ggtgaaggag gaaaagaagg agtaatacat atagaaaatg gtggaagtat aagtattggt
    74401 ataaacaaca taattgctac tgatgggaca gccttatacg ttgaagaagg aggagactta
    74461 catattaaat catcctacga atctgttgaa aaaataaagg caaatggaaa agatgcaata
    74521 ggaatttata ctgaaaatga tattagaata ctaaataagg atattgaagt gaatggagaa
    74581 catgctatag gtgtttattc taaaggtgat gttgagatag aagaaacttc aataaaagca
    74641 tatagtagca acaatgaaag tgggttacta agagataata ataagttggc acaatcaatt
    74701 atatcagaaa gtaagaaagt ttatataatt gatgattata atgagcttat accttctata
    74761 gctgaagatt ctggctatga tattgtgaaa tgttgtcata ggggaattgg tgtatttagt
    74821 gatgaaataa aagtaagtaa agatgataaa atagaaaata taaaatttcc caaatatatg
    74881 gtattagaaa catctagtgg taatcgactt gatatagatg tagaatggga ttttactgat
    74941 tattatgaaa agttggaaaa gggagaaaat tttaatataa caggaaagtt taaaacagaa
    75001 atgttaaata aagaaaaaat tataataaat gatgatgtag ttcctatttt gaatgtatct
    75061 gttatagaga aaaaaccaat agacaatttg gaactggaat ttcaaaatac aaaaaatgga
    75121 tatgtagctg ttttatttta tgatatgccg tatagtgcaa gtaaggtttt tgttgaatat
    75181 tcaagcgatg gaatcaattg gatatctgaa gaacaggagg atattagaga tcaagctata
    75241 cttttttttg aagattttaa gttgcgttgt tttagagtaa aagtggtagg aggattaaaa
    75301 gaagggtatt caaatatagt ttttaaacca ggatttataa tgggaggcgg agacaatcaa
    75361 gagacgccag atgatgaacg ggaaaatgat gatattgatg gtgaccgtgg aggaggaggt
    75421 agagacgacc cggatagaga tgaggatgat aacaatcaag atgggaataa tggaaatgaa
    75481 aataatgata gtaataacaa tcaaaacaat aataatgaaa ataataataa tgaaaatgat
    75541 aattctgatg agaaacaacc aaatactcct aaagatgatg tagaatcaag tactgatagc
    75601 aatgaaaata aaaatcctca tgatatacct aaagacggta ataaagaaaa taattctgat
    75661 aaagaaaaag gattttacaa taaaaattca attacagaaa atgatgataa ttatgattta
    75721 agctcaaaat cagtatttgg taccaatgaa cattcttttc cttataggga aagtatttct
    75781 aacaaaaatc aagatacaaa taaaaataag tcaaatataa gtgattatga tggaataata
    75841 aataataatt ataaattaga atctaaagaa tataatctaa aaaaagatat tattttttta
    75901 ttttgtatac taacaccaat tatgattggt tctatattaa ttgtaaatcc tgatactaga
    75961 aaaagtataa ttaaattcat aaaattaaaa aaataatttt tagaaaggta ttatttagaa
    76021 aatcatgaga ttgctaagta atacctttca ttattatgaa aactgtattt gttgttgaga
    76081 aaacatatat aatatatgaa ttttctaaat agtataaaaa taatagaata ttgaaaaaaa
    76141 attgacaaat gaatgtatag gtattaaaat atattaaata tatacataaa aagtggttta
    76201 ctaacaaata aatgaaatat atgttaacac atagttcaat ttgtaaaaat ataagattta
    76261 taaaaaaata agggaggata ttattatgaa agcaatttta acagtaattg gaaaggataa
    76321 accaggtata gtggcaggaa ttagtgatga attatacaag caaaatatca acatagtaga
    76381 tatatcacaa aaaatattac aggattattt tactatgatt atgatagttg atttagagaa
    76441 atcattaaat tcttttgaga aaacggttga ggacttggtt gaaagaggta agaaattatc
    76501 agtggatgta aaaattcagc gagaagaaat atttaattca atgcataatc tgtagtagac
    76561 agtaagggga ggtgataata gtgaatgtag gaaatatact tgaaacaata aagatgatag
    76621 atgaagaaca gttggatata agaactataa ctatggggat ttctttatta gattgtatag
    76681 accctgatgg agataaagct agagaaaaaa tatacaataa gattatgagt tctgctaaag
    76741 atttggtgaa ggttggaaaa gatatagagc gtgaatttgg tatcccaatt gtaaataaaa
    76801 gggtatcagt aactccaatt tccattattg caggtgcaac agatgaaaat gactatgtaa
    76861 agtttgcaca gacattggat aaggctgcag aagatttagg tatagatttt attggtggat
    76921 tctcagcatt agttcaaaag ggatatacaa aaggtgataa gatactaatt aagtcaattc
    76981 caaaagctct agcaagtact aataaagtat gtgcttcagt aaatgtaggt tctacaagat
    77041 gtggtataaa tatggatgca gtgaaagaaa tgggagaaat cataaaagaa actgcagaat
    77101 taacaaaaga tgcaaaaggt tttggttgtg caaaattagt agtattttgt aatgcagtag
    77161 aagataatcc atttatggca ggagctttcc atggtgttgg tgaggctgat agaattataa
    77221 atgttggtgt aagtggccct ggtgttgtta agagagcttt agagaaagta aagggagagc
    77281 cttttgatgt tgtttcagaa acagttaaaa agactgcatt taaaattaca agagttggac
    77341 aacttgtggc aaaggaagct tctagtagat tggatgttcc atttgggata atagacttat
    77401 cactagctcc tacacctgct attggtgatt cggtagcaaa tatattagag gaaatgggtc
    77461 ttgaagttgt tggtactcat gggactacag cagcattagc acttttaaat gatgctgtta
    77521 aaaaaggtgg agtaatggca tgttcacatg ttggaggact tagtggagcg tttataccag
    77581 tatctgaaga tgcaggtatg attgatgctg ttattaaagg tgctttaagt atagataagc
    77641 ttgaagcaat gactgctatt tgttctgtag gtcttgatat gatagctgtg ccaggaaata
    77701 ctacagcagg tacgcttgga gccatgatag ctgatgaggc agcaataggt atgattaata
    77761 ataagactac agccgttaga attataccag ccccaggatg tgatgtaggt gatatggtag
    77821 aatttggagg acttttagga cgagcaccag taatgcctat aaatacaaat tcatctgaat
    77881 tatttactca aagaggagga aggattccag ctcctataca ttcatttaaa aattagttat
    77941 attacatata ataatattta attaaatatt tagatggtta aattaaagaa gtctatgcat
    78001 ttaaatatta tataagataa tgaactttgt taagataata aactttaaaa atcagttgtt
    78061 aagattatgg caaaaataaa gcgatacatg gacatttaaa aattcatgta tcgcttttat
    78121 tttaataata tctaattaat ataaaatttt ttatgtatct aaaaagttat gctatctaac
    78181 tagtaataaa ctatactaat ttttattcct aatatatcaa ccaaataaaa aactaaacaa
    78241 aaatctaaat aaaaataata aataaaaatt tatctaaata ttcaacacac ataataatca
    78301 taaacataaa taaaaaataa aacgtttgca attaataaaa ttgcctacaa tataaaactc
    78361 tactacttga gatataaatt tataaatctt attgtttttt aagcaatttc ttcttctaca
    78421 tcagtaccac gtatttcacc agcagtaaga actttaaagg tactgaatat ttttgaacct
    78481 aaaaatcctg caattacatt gaataaagca cataaaccag ctgttataag aacttgttga
    78541 actggattat aagcaaacat tatagcaaaa ccagccacag gtgtagctgt acctggtgtc
    78601 atgtttacaa gacccatcaa ggctacaatg ataccagaaa aggctcctcc aaagaaatta
    78661 gtagaatata taggtattgg attagctgaa attatgtctg attgggttaa tggttcaata
    78721 gcaacagata taatatcttt tttagaacct aatttcaatt ttgcaaatag tgttgagttc
    78781 ataaaagctg aaccaaaagc acctaatgct cctattgcca taggaagacc agtaagacca
    78841 attatagatg taagagccat tgaactaagt ggagacgttc caactactgt tattagacct
    78901 cctagtataa ttcccattat tatagggcta atgttggtag cttctatcaa aacttgtcca
    78961 atttgtagta gtgtactatt aactaatggg tctacatttg atgctataag acgagatagc
    79021 ggtgcacata gaagaattac aaccactaaa tccactccag gtggcacttt tttctctata
    79081 aacttaatta agaaagaaac aaagtatcca gcaacgaatc cagataatat agaaaaatct
    79141 aaacaagata atcctattaa aactgcataa actggagata cacctaaggc taaaggcaca
    79201 agtatagcag cagcaactcc accaagacta ccattagcag ctccaacact tctaaaaaat
    79261 tccataccta aaacatcacc aagtaaagaa aggttgaatg cctctactaa gaaagtagca
    79321 catgcagcgt ttgctagagc tcccatagcc ttcataccat atggggcctt gtaactaaaa
    79381 attgtgaaac aacatagaac caataaaagt aaacctgttc ctaataaaat ttctgacata
    79441 agaaaatcct ccttgtattt tttttaggac ataaactttt gttatgataa cgttatccta
    79501 attcataaat gattacctaa ataaatgtca acataacaaa agttatttta aatcttaatt
    79561 ggttttatat tgcatctaaa aataaaaata actataaaaa catataaagt aagcttaacg
    79621 tataaaatgt aaattaaact tatactttat aatacaatta tatataaata atgcagtctt
    79681 gtataggaag attgataaaa aataaattta atatggaaaa aataattatt agaacgtaaa
    79741 atattagctt ataaaaaagg aataaacatt ttttagaaga agtacttata atgaaagtaa
    79801 ttttataggg ggagagtctt tgaaaaaggt aaaatatacc agattagtga tacttggtat
    79861 tcttatatat ttagtattta atatattagt aatgataatt agcaaaaatg tagatacgtt
    79921 ggtgttaaaa aatgaaaaag ttgatgcaaa gattcatgta aaaggaacta tagaaaaaga
    79981 tgccaatgac cagagtaatt atctatctac atacatcagt aaagaagatt ctaataactt
    80041 tgaaaaaaat caaaatgtaa taattgaata tcatgagcaa aaattagatg caaaagttta
    80101 caaaatatat gaaaataata ataaaataat ggtaaaatta aaaataagta accaaattgt
    80161 tgcaaatcag gatacaagtg tcgaagaatt tgatataata tataatcaga tggaatgttt
    80221 aaaaatacct aaaacttcta taaaaacaaa agacaataaa cgtggtgtat atgtaattga
    80281 tgaacaatca caaagtgtaa aatttgtcat attagaagga ataacttatg agaatgaatc
    80341 ttctgtattt gtggattatt ataaaaatga cataaatgga gttacaagtg ttaatctata
    80401 tgacaaaata attttaagac ctaacagtat aaacacaaat ataaggataa agtaggtgat
    80461 aataatgggt tctattaaag acaatttgtc tgagataaga aacaaaattg ataaagctgc
    80521 aaaaaaagta gatagagaca gcaaagagat tacccttttg gcagtcacaa agactgttga
    80581 tgtagactta gttaatgagg caatgaggga aggaatcact tctgttggtg aaaataaacc
    80641 ccaagaatta gctagaaagt atgatattat aggtgataaa ttaaactggc acctgatagg
    80701 aactttgcaa accaataaag ttaagtacat aatcgataaa gtttgtatga tacactcttt
    80761 agatagaatt gcattatgcg aagaaattca aaaacgtgca gaacaaataa acagagaaat
    80821 agattgctta gtacaagtga atatatctaa agaagagtct aagcatggac ttgatagaga
    80881 agaagttgta gactttgtca aagaagtgtc agaaaaatat aaaaatataa aaataaaggg
    80941 tctaatgaca atggcacctt ttatagaaga tgaagatgag ataagaggtg tatttaaagg
    81001 tcttaaagat ttatcaaaac aaataaaaga actaaacatc cctaatgtag ggatggatgt
    81061 tttgtcaatg ggaatgagtc acgattatga aattgctata gaggaagggg ctaccattgt
    81121 tagagttgga acatcaatct ttggagaaag aaactacaat aaaaaataat tactcaaatt
    81181 tgaataaatt ttaaggagga agttaataat gtcaaatgga ataatatcta aatttaagaa
    81241 ttggatagtt gatgaagaag aagattacat tgaagatgaa tatgaaagtg gcatggacga
    81301 tatagttcaa gaagaagaaa tgaacagtgg ctttagtact gcaaaagcaa ataaaattgt
    81361 aaatttacat acaactagcc aaatgaaagt tgtaatagtt gaacctaagg tttatgatga
    81421 agctgcaact atagcagacc atctaaaaca aagaagggca gttatagtga atttggaagg
    81481 attgactaat tctgaagttc gtaaatctat atttaacttt atgaatgggg cagtttatgt
    81541 cttagatgga agtatacaaa aggtttctaa atcaatattt atactagctc ctaataatgt
    81601 ggatatagat gcaaatatga aaaaagaatt agaaagtaaa gcattcttcc cttggcaaaa
    81661 taaatagtaa aaaggcggtt aatatatggg aacaataaga attgcacttt attatctttt
    81721 agatataata gcatggatga tagttataaa aagcttgatg acttggtttc caaatggaag
    81781 acaaagtaaa atttttgata ttttggaaaa tcttacagag ccaatagaag ggccaataag
    81841 gtctataatg tataaatata caaatggacc tatagatttt tctcctttaa ttgcaatagt
    81901 attattgatg ttcctaagac aattagtatt ggttatattc taaggtgata ggatggataa
    81961 attaaaacta acaaatcaca taaaggatat agacttgaaa aataaaatgt ttaaagtgat
    82021 agacaaggct aatagttgta taaaaaacta tgatgttaag tctacggagt ttcttaatcc
    82081 atatgaagtg aaaaatgctg tagcaatatt aaattctaca aatgaaataa aatacagtgt
    82141 ggatggaggt tatgaacaag ctgaaagaag cactgtattt atttatccat tttacatgga
    82201 atatgaagat atagaagata ctcttagatt tttacaaata gaagggaatt tcaaatttaa
    82261 aaatatatct cataaagatt acttagggtc aatactgggt ctaggtataa aaagagaaaa
    82321 aattggagat ataattatac atgatagctt ttgtcaagta gttgtaagta gtgatatttg
    82381 cgattttata attgtaaact tagaaaaggt ttcaagaaat aatgtaattg taaaggaaat
    82441 ttccagagaa aatattgtta atagttcttc aaaatataaa gaagtatcat ttacagtatc
    82501 ttcagatagg ttagattgtg tgataagtgg tatttacaat atatctagac aagatagtgc
    82561 aaaatacata aatggagaaa aagtccatgt caattatgaa aagataactt caacttctaa
    82621 aatagtaaaa aatgatgatt tgatttctat tagaggcaaa ggaagagcta aggtaacaca
    82681 aataggagat attactaaaa aaggaaaaat aaaagttcaa gcaagattaa ttgtataagg
    82741 actaatttaa attatagctg ggaggaaatg taatgctaac tccaattgag atagaaaata
    82801 aagagtttaa aaaaggttta agagggtata gagatgaaga ggttgatgaa tttttagata
    82861 tcatcaagga agattatgaa tctctatgta gggaaaatac agctcttaaa gaaaaattag
    82921 ggttatatca agaccaagta aacaagtatg aaaatattga agaaacacta aaagctactt
    82981 taataactgc tcaaagtgca gcagaagaca cttgtagcgc ggctaataaa aaggctaaga
    83041 taattgttga agaagctgat ttaaaagcta gacaaattat agaacaagct aataaccgtg
    83101 ttatagagat aagaaaagag tatgatgctt tagtcaaaga atttaagata tttagaaata
    83161 aatttaaatc actgttagaa gatgaaataa gaagtgttga tgagattttt tatgatgtag
    83221 atgaaaaatg tgtaaacgca tttgaaggaa caacagtgta taattatagt aatgatgaag
    83281 ctgctacaac tttagaataa gcttgtaatt tgtttatttt ttatgtagaa taattgtgtg
    83341 agtttgagaa atctataaca aagattaaaa ataggataaa aatgtaagaa aaatagaaat
    83401 tattatattt ttcaaaaata tattgactat tcaaattatt tgttatagaa tttcatataa
    83461 acacagataa atttttaaaa gcgttgatag agacatttat ctttagataa ttttacagag
    83521 aattgggtat gctgagaacc aatgaattta taaagataaa aatcactctt gagctgcagg
    83581 ctgaacgatt aaattctact aagctgtgcc ggttagtacc gttatactat tagagtgtta
    83641 tatgtagcta gtatttagtt tacatataga attagggtgg taacgcgatt tataactcgt
    83701 ccctttggtt taaagggggc gagtttttta gtatttaaat ttatgtgaaa gaataaaaaa
    83761 ttttggaatt ataatattta gtaggaaagg gtgatttaca tggcgaaatt taagccattg
    83821 gtagacagtt ctgtaaaaca agcagaagca caagtttttg attattggaa agacataaat
    83881 atacttgaaa aaactttaga aaaagggaaa gatgacccaa gtttcgtatt ctatgaagga
    83941 cctccaacag ctaatggaaa tcctggagta caccatgttt tatctagaac gcttaaagat
    84001 tcagtttgta gatataaaac aatgtctggt tatcaagtaa agagaaaagc tggttgggat
    84061 acacatggat taccagttga aatacaagta gagaaagagt taggacttac tagtaagcaa
    84121 caaatagaag aatatggaat agctgaattt aaccaaaaat gtagagagtc agttttctca
    84181 tttgaaaaac aatggagaat aatgactgag agaatggctt atgaagttga tttagataat
    84241 ccatatataa ctttagataa taactatata gagtctgtat ggtggatact aaacaaattc
    84301 aacaaagaag gatatatata tgaagggcat aaaatacttc cttattgccc aagatgtgga
    84361 actggtcttg ctagtcatga ggttgcacaa ggatataaag aagtaaaaac taatacagtt
    84421 atagctaaat ttaagaaaaa agatgctgat gaatacttct tagcatggac aacaactcca
    84481 tggactttac catcaaatgt ttcattaaca gtaaatgctg atgtagatta tttaaaagtt
    84541 aaaaaaggtg atgaggtata ttatgtatct aaacctttag ctgataaagt actaggtgaa
    84601 gattatgaag ttttagaaga aatgaaaggt aaagacctag aaggtttaga atatgaacaa
    84661 ttaatgcctt ttgtagaagt tgacaaaaaa gcatttttta ttacagtagg agattatgta
    84721 actactgaag atggaactgg tatagttcat acagcaccag catttggtga agatgactac
    84781 aacacaggta aaagatatga tttaccagtt attcaaccag tagatgaaac tggtaaattt
    84841 acatctactc cttgggaagg tagatttgta atggaagatg ggctagatgt tgaaataata
    84901 aaatggctag cttctgaaaa taaattatat agcaaagaaa aagtagttca taattatcca
    84961 cactgctgga gatgtcaaac tccattagta tactatgcaa aaccaagctg gtatatagag
    85021 atgactaaac ttaaagataa attaatagaa aataataatg gtgtaaaatg gttcccaagt
    85081 tttgtaggag agaagagatt tggaaactgg ttagaaaatc taaatgactg ggcaatatca
    85141 agaactagat attggggaac tccacttcct atatggagat gtgaatgtgg tcatacagat
    85201 tcagttggtt caagagctga attagctgaa aaagctatag aagatgtaaa tccagaaaca
    85261 gttgaacttc atagaccata tgtagatgat atacacttaa aatgtgaaaa atgtggaaaa
    85321 ccaatgacaa gagtaacaga ggttatagac tgttggtttg atagtggggc tatgccattt
    85381 gctcaacacc actatccatt tgaaaataag gaaaactttg accaattgtt cccagctgac
    85441 tatatatcag aaggtataga ccagactaga ggttggttct actcattact tgcagtatca
    85501 acatttgtat taggaaaagc accatataag agtgttttag ttccagacct tgtacttgat
    85561 aaagatggta agaaaatgag taaatcaaga ggaaatacag taaatccaat ggaattattt
    85621 gaccaatatg gagcagatgc attaagatgg tatttactat atgtttctcc accatggact
    85681 ccaactaaat ttgatatgga tggattaaaa gaaatccaaa gtaaatttat aggtactatg
    85741 aagaatgtat ataacttctt tactttatat gcaaacacag atgatataaa tccaactgaa
    85801 ttttttgtag aatataaaga tagaccagaa cttgatagat ggatattatc taagttcaat
    85861 aatttaatga aagatgtaga agaaaattta gctatatttg agttaaataa aactttaaga
    85921 atgatacaag attttataaa tgatgattta tctaactggt atataagacg ttcaagaaga
    85981 agattttggg caactgaatt aacagaagat aaaaaagcag tgtacaatac aacttatgaa
    86041 ttgttacatg gtctttgtag agctatagct ccatttgcac catatatgtc agaagaaatg
    86101 tatagaaact taacaggaga agtatctgtt catttagctg aatatcctaa atgtaatgaa
    86161 gagttagtag atactaaatt agaagaaaaa atggatttag ctaaaaactt agttacttta
    86221 ggtagagctt caagagaagt agaaagaata aaagttcgtc aaccattaca aaaagtgtta
    86281 gtagatggta agtttgaaga tacaataagt gatgtagttg atttaataaa agaagagctt
    86341 aatgttaaag aggtaatatt tgctaaagat ttagatgagt atatgaattt tagtttaaaa
    86401 ccaaacttta aggaagcagg gccattatta ggttctaaga tgaatttatt cgttggagca
    86461 ttaagtaaat taaatgctca tgaaactgct aataaacttg aaaaaggtga gactttaaca
    86521 gttgatttag atggtgaagc ttttgaattt aataaggatt tagtattaat aggtataact
    86581 gctaaggaag gatttaatgt atctgttgaa aacaatcttt ttgttatact agatactaag
    86641 ctaactgaag agttgattaa tgaaggttat gctagagaat ttatatctaa agtacagcaa
    86701 ttaagaaaat ctaataactt tgaagtatta gataatatag taatagaata ctgtggtgat
    86761 gatgaaattg ctaaagctgt tgaccatttt aatgaatata tcaagtctga aactttagct
    86821 ttagaaataa acagagtaga tgataaatct ttagaggaac aaaacttaaa tgaccatatg
    86881 acaggtataa aagttataaa aaaatagtta gttaatcaaa atccctatag aaattagttt
    86941 atagatttct atagggattt tttatgtaat ataattatct attcaataaa atgttttaat
    87001 attccaaaat ttacaataaa taaatctgta taaatcatat aaattattta tgtcatgtga
    87061 tagaatatta atgaataaac gtttaagtga ggatgaataa tatttttagg aaactacttc
    87121 tgataaattt atttgtaaat ttatcgtgtg ttatgcaggg tggtttattt attatgcaaa
    87181 ggggtgcgtt ttgatgtatg gtgaaagtaa aaagctaagt attgataata atatattttt
    87241 acaatattgt ctgattatat tgggtatgat tctatcaacc ttaggaataa atttatatct
    87301 agcaccagcc aagttattaa gtggaggagt agctggaatt tgtgttatat tatacaaatt
    87361 atttggtata aatcagggaa tatcaagttt cttgatgaac ataccaatat ttattatagc
    87421 tagaaagtat tttgataata aatttttgct aataagtttt gtcaatatgt tactattttc
    87481 tctagcactg gggctaacac aagatattgc taaatatttc ccaatagatg atactatgct
    87541 acagtgtatt tatggtggtg cattaactgg tataggtatg gggttaactt ttaaagcaag
    87601 agctactgct ggaggacttg atataatagc agccataatg aaaagaaagt atgatatacc
    87661 tatgaaaaat acatttttat ttattaattt ttttgtagta tgtgcaggag cttttttatt
    87721 tggagctaaa ttggtgatgt acactttaat tacaatgtat ataatttctt ttactatgga
    87781 tataggaaaa gattgctttg atagaaaaaa atctatactt ttaatatcaa ataaatatga
    87841 tgaaatatcc aaagtgataa tgaataaaat gggtagagga gtcacttttt tggaggcaga
    87901 aggtgcatat acacaaaata agaaaaagat gatttattgc ataatatctg caaatgaaat
    87961 aggtaaattt aaagatttaa tttatgatat ggatagtgaa gcttttattt ctgtcaataa
    88021 cgttgaagaa gtaaaaggtg gaggttttaa ggataaattt ctttaagatt atatatgtta
    88081 attatatatg ttaaaaaatg acatatgtat tgagattata cctagttaga tgtataccat
    88141 agttaatggg gtacatgaag tactcaataa tatactagga ggtataagaa ttatgttaag
    88201 agagagattt gtagtaagaa atcatcataa tccacataca agtgggtgtt gtgggactgg
    88261 aggagaagga tgctgtggag gagataacca tgaacattca catcaacatt ctcacagtca
    88321 tgggcatgaa catgagcatg taaatggtgt aggtcacgac cataatcatg atgatggttt
    88381 ttcaggtact catgagcata gccatgagca tacacataca catggtcatg aacattcaga
    88441 tgggcataca catgaacata aataaaaaca ttttaaattt ataagagatt tttattttgt
    88501 gattccatga aggtttaaat aaaaattgaa tgttttaagt aaaaattatt gagaataaat
    88561 aagaaagtga actgttaaag tagataactt aaatagttca cttttattaa ttatctaagt
    88621 attaagttta aatccaatga ttaactaaaa aagaagctat attttcataa ggtatttttt
    88681 ctgtttttaa taaactttgg acaactaaac catcaactat tgacatgagt aaaaaagaaa
    88741 atgattcagc atcctgttca ttttcgctac tattatattt ttctagtgat tcaacaattt
    88801 cagatttaag agtagttctc cattcaatat attttaatct tattctttcc tttaaatcat
    88861 tatttgaagt aattgcctca caaataagat acatatgtac cctaccacga ctttctatag
    88921 tagatatttt ctctaagatt aagttaacca tttctatttg agaatttttt gatttgacat
    88981 tttttacaca gtttagtata gcactagtta taacttctaa atgagtatcc gcaatatcat
    89041 atataatatc atctttagat gcgtagtgat aatacaaagt acctttactt atatttacat
    89101 cttttgcaat atcagcaagg ctagtatttt gaactccatt tttggctatt aaattggttg
    89161 cagatgataa aatagcctgt ttcatattat ttgttttcat aaaacctacc tttccatgta
    89221 tatttataac aaattaataa cattataagc ttatggatat ttattgtcaa taaagcgaga
    89281 atctatatct attgactttt tttcattcaa tatataaaat aataattaaa tcggtcgtac
    89341 gaccgactga ataaataaaa taatatctta tagtgaggtt aatatggata aaataaaatt
    89401 gatagtggac agtgcatgtg acttacctga tgatataata gaaaaataca acatagaagt
    89461 tgttggttta aatgtatctt ttggagaaga aagttatata tctggaaagg aaatagataa
    89521 tgaaactttc tatagaaaaa tgagtgagag taaagtacta ccaaaaacat catgtccttc
    89581 tcctgataaa tttttagaag cataccattg tcaggaagaa agtgtattag tgattaatat
    89641 aagttcagga ttatctggga cttataatag tgcactttta gcaaaagata tgtttgaaaa
    89701 ggaaggaaat aacaagaaag ttgaggttat agattcactt agtgggtcaa ttggaatagg
    89761 acaattagtg ttaaaagcag caatattaat aaaagaagga aaagaaattg aagagattgt
    89821 ttcaataata aataaatata aagataatcc tccatttttt ggaacacttg aaactttaga
    89881 aaatgctatt aagggtggta gaataaatcc aatagcagga aaaattataa ataccttaaa
    89941 ttttaaggcg ataatacaag ttgcagatgg cgttgtaact cctatagata aggcaagagg
    90001 tgaaggaaac agtttgaaaa agctgattac tttagtagag tcaaaaatta aagataaaga
    90061 agaaaaggtt ttatttatag gacatgctaa ttgcccagaa aaggctcaaa aggtaaggga
    90121 agttatggaa aaggatgtaa aatacaaaga tgttgtaatc tgtgaagttg gttcagtgat
    90181 ggggacatat acttcaaagg gtgcaatctt aataactgca atataaatac tgcaatataa
    90241 ataatggatt gaaataaatc atagattgag aaattaaagc catataaaaa tgtttaaaac
    90301 atttttatat ggctttttaa ttttatcaaa ttgattttag aattaaccaa ctacacatat
    90361 ttctttgtca tgtttgttta atatctcaca accatcttca gtaacaagta ctaaatcttc
    90421 tattctaact ccgaactcac ctggtaaata tatacctggc tctatagaga atatcattcc
    90481 tggttgtaca gtatctgtat ttatagaaga tacatctcct ttatcatgaa cttcaagtcc
    90541 tatagagtga ccagttctat gagtgaagta ctgtccatat cccttttcag ttatgtagtc
    90601 acgagcagca gcatctatat cacagaatct aacacctggt tttacaatag cttcagctct
    90661 cttattagct tcaagaacta tttcaaatat ttctctacct ttttcaggta tttctttata
    90721 gaatacagtt cttgtcatat cagcacaata gttatctttt atacaaccta tatctaagat
    90781 tattgcatct cctggtttca caagtgcatt tccaggttca ccatgtggat tagctccatt
    90841 aggtccaaaa cctataatag ggtcaaatga aaatccatca gtacctaggt cttcatatat
    90901 tttagataat ttaccaacaa gttgtttttc tgtaagttca ccagaaacag tagctttaag
    90961 ttgttccata gccttgtcat ttaattttga agctattctc attaactctt tttcttcttc
    91021 atctttacac attcttaaag tatctattat ataagatgaa tttacaaact tacttcctcc
    91081 acctaattct attaagttta ataagaatct agctggccag tttttatcaa cacccatagt
    91141 agcatttttg tctatatgtt cagttattat ttctactgga ttttgagtat cattgaacca
    91201 aaccatttca acacctaaat cttctgaaac tgggaataat tcatttataa ataatttatt
    91261 attgccattt aaatttaagt ataatgctaa tagtctttcg cctggatgga ttagtactcc
    91321 tgtaagataa aatatagaag tagggtcact tactaacatt tgagaaatat catctttttt
    91381 catttgttca agtacagcat ttaatctttg agctttcata ataatttcct cctaatcaaa
    91441 attcaataca aatcaatttt agcattatta aacaaaaaag agtatacttt tcttctagaa
    91501 atataaaaaa aatttgttat atatttttta tattaagttt aatctctact tttgcattaa
    91561 atacggaagt aaaatgactt tttattgtga aaattctata aaagtaataa attaagtcta
    91621 taaagttatg tattttatct ttttatatac taatgaaaaa taataaataa aattttataa
    91681 taaaataata ttgaaacaat tttaaaaatt tagtatcatt agaattaaag tggtaaaact
    91741 tttaaattta tcatttttaa taagatttga tttcaaagta tttaaggttt attattaaaa
    91801 ctgtttttga atatgcaaat attttgaaaa atatcagttt aataataatg aatctatttt
    91861 attaattttg aaattaaatt taaaataatt aatagagagg ggaaattaaa ttaggatgga
    91921 aaagaaaaaa ataggcctat ggagtttggt atttatgaat gtatcagctt tatatggtat
    91981 aagatggata gctaaatcta cagcatcaag ctttggttta ggattaggtg caatacctat
    92041 gtggttatta ttctcattta tatactttgt accaggagct ttaatttgtg ctgaattagc
    92101 ttctacatat caaaaaggtg atggaggtct ttacgattgg gttaaggaag cctttggaga
    92161 aaagtatgga tttttagttt cttggttaaa ctggacagct aaaatatttt ggtattcttc
    92221 atttttaact ttcttagcag taaatgtttc ttatacaata ggaaatccag cccttgctga
    92281 taataagatg tttgtactta tattatcttt aataatattc tgggcattat ctcttatagc
    92341 aactaaagga ataagtttta caaaaatatt tactaataca ggtgcattag gttcaacaat
    92401 accaagtgct atacttataa tattttcatt tgtagcagta tttgtattga aaaaacatga
    92461 tatagcttct acatacacaa tagcttcaat gactccaaaa cttaatatgg atgcatttgt
    92521 tgctatatca gctataatgt ttggtttagc aggagcagag actgctgcta acttcataac
    92581 agaaatagat aagcctgaaa agaacttccc taaggcaata ttaatatcag ctggaatagt
    92641 agcttcatta tatgtattag gttcaattgc aataacaatg ataataccac cagaccaaat
    92701 tactgcttct aaaggtgtat tagatgcact ttctgctgtt tgtgcgtctt taggaattgg
    92761 ttcttggttg gttcaattaa tagcttttgg tatagctttt tcagtattag gagcaatagt
    92821 tctttacata gcatcaccaa taaaaatgtt atttggtagt gttaaaaaag gaatatttcc
    92881 agatagttta gtagaggtaa atgaacacaa gataccttct aaagcagtta tacttcaagc
    92941 aataatagtt actataatac tattggtgac tacattaatg ccttctgttg atgctatata
    93001 caatgttctt gtaactatga cagcattaac tgcattattc ccatatgtat tgttatatgc
    93061 ttcttatatt aaactaagaa aagagagacc agatgaaatt agaccttata ctatggcaaa
    93121 atcaacaagt acttgcctag gtttagcaaa aatggtttta gttgtaactg tagtgggtat
    93181 attattatct gcagcaccag ttatgcctac atttgctgaa aatgttatat atgagataga
    93241 gatgattggt ggaggtcttc tagttatatt atctggtcta tggttatgga atagatatga
    93301 aaagaaaaca gctaaataaa atgtatttta aaaatttctt ttggatatta taatatatag
    93361 ttgacaattt atagtgtaag gaatattata aaataaagaa attaataaat taaatcctga
    93421 gataagaaat agtaaataaa tatatttttg cacagagaat taaggatgct gagaacttaa
    93481 taaaaagtat ttattgaatg ggtctttgag gagtaaaatg aaatgtaatt taagattaca
    93541 gagtatttga tatcgtgtat gcacgttata gcatatatta agatatatat attcaatttt
    93601 gagtgtatat aaatttaggt ggtaccacgg aaaatatatc cgtcctattg atttaggacg
    93661 gattttttaa tatagaaaat ttaggaggaa aaatgaacgt aataggaatt ataggtgcaa
    93721 tggatgaaga agttagtatt ttagttgatt taatggatat tagagagact ataaaaaaag
    93781 ctagcttaga attttataag ggaattttgg aaggtaagaa tgtagtgtta gtaaagtgtg
    93841 gcataggtaa ggttaactct gctctttgtg cccagatact aataagcgaa tttaaggttg
    93901 atgctattgt taatacaggt gttgcaggag ctttaaacga aaaacttgat gttaatgata
    93961 tagtaatatc aactgatgct atacagtatg atgtagacac tacagcattt ggagacccta
    94021 agggagttat accaagaatg aagacttctg tatttaaagc agatgaaaga cttatagatg
    94081 ctgcttacaa atcttctgtg gaagaagtaa agactcataa agtattaaaa ggaagagtag
    94141 ttacaggaga taaatttata aattctaaag aattaaaaga agaattagta aatgattttg
    94201 gtggatattg tggagaaatg gaaggtggag ctatagctca tgtatgctat ttaaataata
    94261 ctccatttgt aataataaga gcaatgtctg ataaggcaga tggaagtgct gatgttactt
    94321 atgatgtatt tgtacatgat gctgccaata actctaaaga catagtttta aatatgttaa
    94381 aatcaatata aatatataag gaggtacaaa aaaatgagtg aaaaaaaagt tatattaagt
    94441 ggtgcacagc catcaggcaa aatgacttta ggaaattatt taggagctat aaaaaactgg
    94501 actgaacttc aagacaatta tgattgttat tatagtatag ttgatttgca tgcaataaca
    94561 gtacctcaag accctaaagt tttaagagcc aatactatag aattacttgc tcaatatata
    94621 gcttgtggat tagacccaga aaaaaatact atatttatac aatcacatgt caaagagcat
    94681 gttgaactta tgtgggtatt gaatactatg acttatatgg gtgaattaag tagaatgact
    94741 caattcaaag ataaatcaca aaagagtgaa gcaaatctaa atgcaggttt attcacatat
    94801 ccagttctta tggctgctga catattgttg tatcaaactg acctagttcc agttggagat
    94861 gaccaaaaac aacatttaga attagctcgt gatttagcaa ataggtttaa taatagattt
    94921 tcacctactt ttgtagttcc agaaggatac tacccaaaag gtggagcaag agtgatgagt
    94981 ttgcaagagc caactaaaaa aatgagtaaa tccgattcaa atgaaaatgc atttatacta
    95041 ttagcagatg attcagattc tataaagaga aagataaaaa gaagtgttac tgattcttta
    95101 ggtgttgtaa aatacaatga tgaacaacca ggtattaaaa acctaattga tatatattct
    95161 aatttaagta aaaagagtgt agaagagatt gtaaacatgt atgaaggaaa gggttatggc
    95221 atatttaaag aagatgtggc tgaagtagta tcagaagctt taagacctat aagagaaaaa
    95281 tatgttgacc ttcttaataa taaagattat ttagaaaaaa tatatagtat gggagcagaa
    95341 aaagccgaaa aacaagctag aaaaactctt agaaaagttt ataaaaaagt tggatttata
    95401 gagagaagat actaattatt agctatcttt acttgataaa taaattttaa agttattaaa
    95461 aaggtatatg atatgaaaga gagagtctca aagtgaactt ttgttcatga ggcactcttt
    95521 tttgtatgaa ataaaatata ttttaatcat ttcaacaatg aaaaagagga ttatctctat
    95581 tttgagacag catcttttga taataaaaaa agatgagctt ttgctcatct caaaggggtt
    95641 agattattct tactttgggg aaagtagaat aaaggtaaaa gttaactgat gtcaactttg
    95701 tcttttttgc atatcactac tgagcataaa aaaatcagaa aaccatagcc ttctgaaaca
    95761 acttctaaca tacattgtat tttataccca atatgtaatt tatgagttaa ttttaactct
    95821 tataatgaaa attgtcaata atatatcaaa aaaatatttt ttaaatttat ataattaaat
    95881 gaatttatgt ttatatatag gtgatatgat acagataatt atctttttaa tacaatatag
    95941 ttctaaaaaa gaatatatta gaagaagata atatttaaat aaaaaatacc ttataaagtt
    96001 aattttttaa tactttataa ggtaaataca tattgtattg tggggataaa tttaaatcat
    96061 ttgatactaa tcaacactaa gaaccaataa ctctctatca tcttgagtaa ttgtatatat
    96121 tcttaatttc ttgtatgtca taatattttc tccacctgta aaataactcc taagattaac
    96181 acaatcagtt ttaggttgat ttgtatctcc taaataatta cgcaattctt tatctttagt
    96241 ttcaatatct ttaaatccaa aatattgtaa agtagcttca actctatatt tttggacata
    96301 atcgagagct tctttattag tttatgttgg tgtaaaatac ataccattta tataagcctt
    96361 tattgtactt ggattaaatt taaaatctgc agaatatatt ttatgtgtaa ctattatttc
    96421 ttgaacagtt ggaattttaa cttctggttc atcaagtatt tcaggagtac tatttagctc
    96481 tgtaatagat aagttatcta agtatattgt atcactatca attaatgcta tatttatatt
    96541 agaagaatct ttttcagtag tttcaaattc ataactaaat tttgtatatc cttgttctag
    96601 taccaaataa tccgtttttt cttcttttac ttttatattt acaattattg aattatatgt
    96661 taaaggattt tttgaatttt actaaaaaca taacgtttat aaggttttag ttcagacata
    96721 ggtattttaa tcttcgtctc accatttaat ctatttgctg agccttttaa accatcttga
    96781 tttgtagtat taacattact ccatatacta gggtaattat tgtaatcatc aaaattagta
    96841 aagtaagttg gtgtttttat aagtatattc attcctcttt caagtttaac attacatatt
    96901 tgtttatcag acaaagtttt taaactgtct ttaatcttat tgcctatatt atcatcaaat
    96961 atgagttcaa cacaactttc atctattggt atattattaa aatataacaa accatctttt
    97021 ttagtagtgc caaaagtttt ttcaattgct tctccaattg taagttcagg tgttttatct
    97081 tctgggacct gtaaactttt agcagtaatt cttcttttgt aagattcatt ttctgtatct
    97141 aatataatag atacagaaat actgtcaatt tgacctatat cgtcttacca actatttcat
    97201 tctgttacta tttgtccaga accatttttt gtaccaaaat ttccacttac ttgtgttgtt
    97261 tctaatttaa tttgctttcc atcatctaat ttttttaatt aattataatt tataggaatc
    97321 agtctagaac taaattgata cattgtgtta agagccatag gtgaaaatcc ttttttgaga
    97381 taagtatttc caggagatag attattgcca atttgatttt cttgtgcttt gatagttgat
    97441 aatgcatctc catctaacac taaatttgtt gttggtgtca ctttgtacat aggtgcagta
    97501 cctgtgttgt agtatctaat atttgcattt atatatgcag attctccttt gtttatactt
    97561 aatccagtat ttcatgatta tccattgcta ttttgaacag cagttgaatt atctgttgta
    97621 tggtaataat ttgtcttgta tagtttcttt aaactcatta aatttttcta atgaaatttc
    97681 gttttgattt tttgttctta ttactttatt aaatgcaaat ttttctggag attcaaaata
    97741 atatacatac ataggtttat ctattttatt ttttgatata gcatttcgaa gttctctata
    97801 ttctttttct caagaatttg cttctatttg ataatcataa aaataatttc ttgtctgaga
    97861 atatttgctt atctctatag aatctttttt atatgatcct aatacttctt tttcagattt
    97921 ttcaagtttt tgatcttttc tttctcattc tttagccttt tctttatctt taaaaaaatc
    97981 cttctgatct ttctatagga gccttgtaag tagtattaca aacttttcca ctatagcttt
    98041 gtaaatcttg tgcataaatg ttattaggta acaaactacc taaagttaga tataatatca
    98101 acaatataga tatacaatta ctaatacttt tatgtttcct aaattttttc atttattctc
    98161 cctacaaata ttagtttagt taacttttga attttaattt atttagatta tataatctaa
    98221 ataagaattt tttatataaa tttcataaaa tatgtaggta tatatcataa aaatatgtat
    98281 ttatatgata tgtcagtaca aaataacaac tgaatatttt aaagagacta tttcgtactt
    98341 ttatgattta atgagctatc ttatcgaatc ataatctagg aacaattgtt ataatatcta
    98401 atagtagtta tatatgatat agtcagtatg tgttttttca caatatgatt attatataga
    98461 ggattcttag ggattactct ttttgtataa aaaagagatg gttcaaattt ttatcttgag
    98521 acatctcctt tttctattta ttatgtttta ataat
//
LOCUS       DAEPID010000005        95278 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.005, whole genome shotgun sequence.
ACCESSION   DAEPID010000005 DAEPID010000000
VERSION     DAEPID010000005.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 95278)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 95278)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..95278
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.005"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            565..1214
                     /locus_tag="KR257_000376"
                     /pseudo
     CDS             565..1214
                     /locus_tag="KR257_000376"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429361.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="tyrosine-type recombinase/integrase family
                     protein"
     gene            1755..3110
                     /locus_tag="KR257_000377"
     CDS             1755..3110
                     /locus_tag="KR257_000377"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438549.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MATE family efflux transporter"
                     /protein_id="HBH0029104.1"
                     /translation="MDTKISINENMSLGKRFFKYLAPSVVAMWVFSLYTMVDGIFVSK
                     GVGELALAAVNISMPFINFIFAVSLLFSTGASTIIAIYLGKKDIKSANEVFSFNLVSI
                     IILSIIILAITFFNLDRLALFLGATESTIGMVKDYLGIIIFFNGFFIVSYSLEVIIKT
                     DGFPILATVGVIISALTNIILDYLFVIEFGWGVKGAGIATGLSQVFSTIFFLIHFLRK
                     NSTLNFSKFRIDFKTLRKIVFIGFPDSTTELSCGIVVLLFNLSLTKYIGENALIYYSV
                     INYINTLVLMTMMGITQGMQPLTSFYYGAGNIDNVKKLLKMGIKATIIASVAVFAICM
                     AFSGPIVSLFIHPEETMLFNEGVRVFKIFSISFLLVGINVIISGFFVSVEKPSISTVI
                     SLGRGLVIVVLSLISMILIFGGQGIWMTTIVSEFICLILSLVFLKKNFSTLDSNLNKV
                     A"
     gene            complement(3228..3896)
                     /locus_tag="KR257_000378"
     CDS             complement(3228..3896)
                     /locus_tag="KR257_000378"
                     /EC_number="6.3.1.14"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429358.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="diphthine--ammonia ligase"
                     /protein_id="HBH0029105.1"
                     /translation="MKEVLKLADEKFVMSFSGGKDSILALNRMLKKGYKPVALLTTIS
                     EEHGKSWTHNLEYNMLKQVSSNIGLPLLVAECGVEGYEESFERALIKAKNMGATICAY
                     GDIDIESHRKWDTDRCEAVGMKVDLPLWQESREDLVYEFIDSGFCSVVTKVNLKHLGE
                     EFLGKKLTRELVEKIKNAGADPCGEHGEYHTFVVDGPIFKKPVEYEVKGTLIKDGYGY
                     LEIK"
     gene            complement(3963..4391)
                     /locus_tag="KR257_000379"
     CDS             complement(3963..4391)
                     /locus_tag="KR257_000379"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429356.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DMT family transporter"
                     /protein_id="HBH0029106.1"
                     /translation="MTKLWAIIFALLAGGSTALEAFINGELGKSTTALVATFISLTVG
                     AIFFLASIIVTGDLKCLVSINGFNYKLLLGGVFGGLIIYFTVKAIPNLGVSNTLILTL
                     VSQVLVGFFIDSVILGQETMHLYKYIGVILLILGTFFIVN"
     gene            4498..5091
                     /locus_tag="KR257_000380"
     CDS             4498..5091
                     /locus_tag="KR257_000380"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419829.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF308 domain-containing protein"
                     /protein_id="HBH0029107.1"
                     /translation="MNFCYNCSIDFGGDFMYTNFNIDFNNFNKKENAIKFMLMGVLLI
                     ILGLLCLTFKTLGIKLISWTFGIALLFFAYLNLKNINELKRYATKEEIKPSINIQWVL
                     IIACILLFVFPQKIQSIFSLFLGFYLIFNQLVALVNSKNNPYSKFTTWNIVKILFGIC
                     LILSPLFLSRFIVSIMSFFIILFGLVLFFSGNTARKY"
     gene            5210..6145
                     /locus_tag="KR257_000381"
     CDS             5210..6145
                     /locus_tag="KR257_000381"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893027.1"
                     /note="This family includes YhcC from E. coli K-12, an
                     uncharacterized radical SAM protein; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TIGR01212 family radical SAM protein"
                     /protein_id="HBH0029108.1"
                     /translation="MDKFKYAFDNKRYHTWNYYLRNTFGEKVFKVSINAGFTCPNIDG
                     SLGYGGCTYCSKEGSGDFAGNPKDNLISQFYNIKEMMLKKWPHAKYIGYFQAYTNTYA
                     PLEVLKEKYETILELEDVIGLSISTRPDCLPDDVVEYLSELNKRTNLWVELGLQTIHD
                     STSKIINRGHDYKTFVEGVEKLKSKNIKVVVHIINGLPGEDYNMMMETAKAVGKMGVD
                     GIKIHLLHVIKDTPMEKMLQNGMLTLMEQDEYINLVCDQLEILPETMIIHRLTGDGKR
                     DELVGPIWSLKKWEILNQIDDTLKARNSYQGCKFV"
     gene            complement(6416..7360)
                     /locus_tag="KR257_000382"
     CDS             complement(6416..7360)
                     /locus_tag="KR257_000382"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438541.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="EamA family transporter"
                     /protein_id="HBH0029109.1"
                     /translation="MGEKSKGYVFIAIAGLLWATLGLFGKFLMGNGLTSEQVAFTRLF
                     FGFIVLGVYSSIRTPQILKISKKGIIYSVIIGIICQAMFNLCYFKAIDIAGVSIAAVL
                     LYTSPLFLAIFSKICYKENITRSKLFSLILCFIGAIMAVTGGRLDFQGLNAFGLLLGV
                     LSAIAYALMPTISKNALKEFSSSTILVYSFLFGAIFMIPSSRPWEILNYAKDLDVLSC
                     MLMLGIVPAALAYIFYAAGISKGVELSVAGVVASVELVGSVIIGCTILGESFSLGKLF
                     GVMLMLISAVVALNLSYDEIRIFYKSNKLKQIEKTESI"
     gene            7678..9108
                     /locus_tag="KR257_000383"
     CDS             7678..9108
                     /locus_tag="KR257_000383"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729573.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sigma 54-interacting transcriptional regulator"
                     /protein_id="HBH0029110.1"
                     /translation="MNLDLEFYQKILEASHDEICVSDDKGIIIYCNKAFEENYGLKKE
                     DILGKNVSFLEDSGYSTKSPIPIVLKTKTKFSLEQDTQTGKKLIITATPIFDENGNLE
                     FTVENCRDITELNNIKNKLEDTKKQVKKYKSEVETLYRTALRIEDTVIMDGIVMRPII
                     NTVNHVSKTDVSVLLLGESGTGKSSLARYIHHNSNRSNGPFITINCATISPQLLESEL
                     FGYTSGAFTGASTKGKVGLVELANGGTLFLDEIGDIPQNLQAKFLQLIQDRTFTPVGS
                     LKNKKVDIRIISATNVDLVSKVKEKKFREDLYYRLNVIEIKLPPLRERRDNLVEIIKY
                     YFNRYSSDFNLNKTISKEAMDAIANYRFPGNIRELQNIIQKILLTCTDNHITIDDLPN
                     ILTKNIHITNNGNKTHISQINKVIISDSKSTNYKNKNFDTLIKEYEKNIILDAYEKFG
                     SSYKVAKHLEISQSKANRLIRKYTNT"
     gene            9308..9892
                     /locus_tag="KR257_000384"
     CDS             9308..9892
                     /locus_tag="KR257_000384"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419819.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="zinc dependent phospholipase C family protein"
                     /protein_id="HBH0029111.1"
                     /translation="MLMNTHFIMAKSILDNIDENKTFFISEKNFIYGNIKPDAFSKYK
                     LKKHYLDESFNMIVSKINYLCSLNIDSLSKYFSVSRLSQELGVICHFLCDFFCVAHSE
                     RWEFKHSLNKHVTYERELGAFAKDVDLSKIKCGTINSSFEKFFTKLYSDYKKKTDYMN
                     DLKFSAYTCNSVINYILDSILSNTIKSYHIANCG"
     gene            complement(9996..10775)
                     /locus_tag="KR257_000385"
     CDS             complement(9996..10775)
                     /locus_tag="KR257_000385"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419804.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Cof-type HAD-IIB family hydrolase"
                     /protein_id="HBH0029112.1"
                     /translation="MIKHIFCDLDGTLYENGTITKEDIVAIEEIEKKGVQFNVATGRI
                     FKQAHNIIKDSLDMNGYYVCENGSFIYDKDYNVIFKRTIDDNLVKKVIDRFESSDAQL
                     YFKYKGDVIVGSDTTAFRHYSSDFIVDPDFEKRSSFDNLIGNIGVCSENLEELSRIEL
                     YLKSEFSEVLEIYFSGTYTLNIVPKSVSKRGSIEHVIKTLNVSPDEVATIGDSPNDIC
                     MLEGFKYSFAMSKAREDVKQSANYVVDSVKSAIDVIMEINS"
     gene            complement(10833..12089)
                     /locus_tag="KR257_000386"
     CDS             complement(10833..12089)
                     /locus_tag="KR257_000386"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011591286.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="competence/damage-inducible protein A"
                     /protein_id="HBH0029113.1"
                     /translation="MKAEIISVGTEILLGDIVNTNSQFLAKELASLGIEVYHQSTVGD
                     NKQRLLECFDESLKRSDFVITTGGLGPTGDDMTKETAAEYFGQKLELHKPSLEVLESF
                     FVKTGKKMAENNMKQVYFPKDAIVLKNNNGTAPGAILKKDGKFIIVLPGPPREMKAMF
                     NESVKPYLQQFTNEMLVSKTLRLYGIGESNLELEILDIINEQTNPTVALYAKELEVTI
                     RITAKAENEREAFKLIKPVEEKIKSRVGKYVYTEGDISISEGETALEDAVSKLLVEKN
                     LTIAVAESCTGGLVSSSLINYPGISSVFLEGCVTYSNDSKMKRLGVKRETLEEFGAVS
                     EQTAIEMAEGVAKGLKANIGISTTGVAGPGGGTKEKPVGLVYTAIYINGKTIVKKNIF
                     NGDRRKIRLRATRDLLNELRIQLEKL"
     gene            12347..13246
                     /locus_tag="KR257_000387"
     CDS             12347..13246
                     /locus_tag="KR257_000387"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429344.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="D-alanine--D-alanine ligase"
                     /protein_id="HBH0029114.1"
                     /translation="MKIAVIMGGISSEREVSLNSGKEIYNNLDKNKYEVVKVIIDDKK
                     DIFTKIPEDIDFAILALHGKFGEDGCIQSILETMDIPYSGCGPLCSGMCMDKNITKKM
                     LRDSNLPTAPWVLVKSVDEIDYDEIDNIGYPVFIKPNSGGSSVATFFIHSKDEVEEAV
                     RKGLEVDEFVMIEKYIPGGEYTSFILNGEVFPTISIKSDSGFFDYEAKYSVEKGAKEE
                     VVYLDEELQKRVNEISETCWKIFNCKAYVRVDMIISEGIPYVLELNTLPGMTQTSLIP
                     RSAAARGIKYSELLDKLIEYSLN"
     gene            13270..14718
                     /gene="ddlR"
                     /locus_tag="KR257_000388"
     CDS             13270..14718
                     /gene="ddlR"
                     /locus_tag="KR257_000388"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902483.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcriptional regulator DdlR"
                     /protein_id="HBH0029115.1"
                     /translation="MIFSNLKLNDNEPIYIQLKNYISDMISKGLIPDNSKLPSTRELS
                     QLLQVSRNSVVLTYEELKSEGLIYSISGKGTFVKSKNKSSNTTWSLNWDCLENTYSKK
                     ANELDIIKSEIPWSSDLISFKSISPDGDLFDIEELKKSFLNRISLEGHKLLNYGYAQG
                     YKPLIDYLLEYMTNKGADISNKDILITNGFTEGFDIIMSSFTQEKDYIICENPTHNTA
                     IKIMKSHNLNILGVDINEDGLDFNMLEDNLVKYKNKIKFAYITPSYHNPTGIVMTPEN
                     RYKFYNLMKKYNIAIIEDGFNEELLYNSSHIFPICSLDNMNNGVVYIGSFSKILFPGM
                     RIGWIFADKKVINKLESVKRCRNIHVSFLDQGILFDYLSNGGFEKYIKKIRKFYGDKF
                     NFAYKCIKKYIKTEYILGDGGLHIFIKLKNIDTRVLLEKCYEKNVIFMPGDLFFTDNS
                     GFDTLRLGFSRLSFEDIEIGIKIIGETINEMF"
     gene            14777..15583
                     /locus_tag="KR257_000389"
     CDS             14777..15583
                     /locus_tag="KR257_000389"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012816121.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="M15 family metallopeptidase"
                     /protein_id="HBH0029116.1"
                     /translation="MNLILGDNMSKKSKRRKINKLKLTIVITVLFLALLSIYEILFSN
                     PNKKGNIKSQETMQNKNNTTDDSKNNQSSTKKQEDNNIKPTFSYSSIPDNIKNKMIGK
                     SMPTDEPISFDSLSYLKLTYYGFDEKTHQGEMIVNSELAPEVVDIFKELYEKKYPIEK
                     IKLIDDYDAVDEKSMSDNNTSSFCYRTIAGTNVVSNHGKGRAIDINPLQNPQVSGNDV
                     TPKVSTVYADRSSTKFGMIKKGDDCYNAFVSRGWSWGGYWKNPDYQHFEK"
     gene            15609..17528
                     /locus_tag="KR257_000390"
     CDS             15609..17528
                     /locus_tag="KR257_000390"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_071223118.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC-F family ATP-binding cassette
                     domain-containing protein"
                     /protein_id="HBH0029117.1"
                     /translation="MNLMTLENISKSYSEKKLLENISLGINEGEKIGLIGVNGTGKST
                     LLKIIAGVEESETGNITKTNGIRIEYLPQNPTYNENSTVLEQVFNGTSEELKLLGEYQ
                     EILEKLNSNFTEELNKKLLSVHEKIDALNLWDLESEAKSVLTKLGINDFNQKIAELSG
                     GQRKRVSLASALITPCEFLILDEPTNHLDNDTIDWLEEYLNSRKGSLLMITHDRYFLD
                     RVTNRIIELDKGRLFSYDGNYSIFLEKKMERLSLEASIEDKRQNLIRTELAWVRRGAQ
                     ARSTKQKARLQRFDELINRDSFKPDENLDISVASSRLGNKIIEIHNISKSFEENTVID
                     NLEYTLTRTDRIGIIGKNGMGKSTLINILNGEIEPDSGYISIGETVKIGCFSQDDSHM
                     NIDMRAIDYVKEASDYIETSDGTRITASQMCERFLFNGTMQYTLIGKLSGGERRRLHL
                     LKILMTAPNVLLLDEPTNDLDIETLKILEEYLDEFKGVVVTVSHDRYFLDRICNKIFA
                     YEGNGKIHIYTGNYSDYLIYREIQGIEFEESKKESVKKDDSTTLKKEKPKNDKKLKFS
                     YNEQREFENIDSDIEKLESKIATLDESTAKFSTDFTKLQEILDEKSKLEKELEYKYER
                     WEYLNNLADEIANNK"
     gene            complement(17770..18117)
                     /locus_tag="KR257_000391"
     CDS             complement(17770..18117)
                     /locus_tag="KR257_000391"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419773.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PqqD family protein"
                     /protein_id="HBH0029118.1"
                     /translation="MSKSNDVLDIVFKITDGLEYEVAENRVVTILEKQDHKIQKFFRK
                     LKARIPKYKKIELDEYSSFVFLQIDGQRTVREIGKNLEAKYGEESHPLYERLLVFLNH
                     IEVNCHYIERLDI"
     gene            complement(18104..20032)
                     /locus_tag="KR257_000392"
     CDS             complement(18104..20032)
                     /locus_tag="KR257_000392"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902476.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="oligopeptide transporter, OPT family"
                     /protein_id="HBH0029119.1"
                     /translation="MNKKLPKGAYGEVSGKDYVPYITDKSRTGGNVAVLIIGIILAAI
                     FAASTTYSGMKAGLTVAAGIPGAIIGSAFVGAFARSKGILGKNLIQGMSSGGESVASG
                     FIFVLPAVILIGSQITFFEGLAVGVGGVLFGIGIAAIVHNYLIVEEHGKLMYPESMAI
                     SETLVASEAGGDSIKYMGIGFVISGFITVLTGSFLNVANNVMSLVGSKFYKWKFDIEV
                     NPLLLGIGFIVGLEVSLTMFAGSILSNFGIAPLIGYFTDMAKDGAMVWNNPAMPLNQM
                     DVGAISSSYVKYIGAGMMLCGGIIGAIKLIPTIIASIKETLKAKSSAGEGEEGSSIQM
                     ILLLGGVVIGFLAAFLISGNIVMAIIGAIISLLLSLLFVIVAGRLTGTIGTSNLPVSG
                     MTIASLVIVTLVFVIMGWTDLEANKSLLLFGSFIVVAIAIAGGYTQSQKVTYIIGGSK
                     NEMQRYFTIASIVGVIVVVGVILLLSDQLRATGDNVQFALPQANLMSTLTSGIMSGSL
                     PWVMIIVGVFMAIVLYALNLPIMTIAIGFYLPIATTSIILVGALIRLFVELVSKTEKE
                     KEVKVSNGISLSSGLVAGGSIIGLIGIILQVTGVVTPKVPSGFAATNSMAIALLVVLV
                     VLTALPIVLSKVKNNEQE"
     gene            complement(20443..22632)
                     /locus_tag="KR257_000393"
     CDS             complement(20443..22632)
                     /locus_tag="KR257_000393"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419766.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amino acid adenylation domain-containing
                     protein"
                     /protein_id="HBH0029120.1"
                     /translation="MYEVNLERAMNYWMDLLDDYTNIAKIPNDFFYKDCSDEVVDEVF
                     KMNIEKHERLIQYSKVNNISIDSIIETIYGLILQKYIYEDDVVFGKTMNIIPIRVRVR
                     QSEKFIDVVRKLKRQWSRSLEYGYYLLSDIENKNHLNTKLINTIFIAKSFDLSYDYDI
                     EKKGYDLSVIVYTKRALKIKIKYKPSIYKRETIRRILNQFDYIIEQIIEDNDILIEDL
                     EFVCKEEEKVLLEDFNNNQYEIPYDKSYVDLFREQVKVTPSNIAARDENRKLTYKELD
                     EVTDKLAGYLNHIGVESEDIVAVMLPRDINIIITAIGIMKSGGAFFPIDTSNPEERLN
                     YLLEDSNAKVVITTDELKSKVVNENTIVLDINDEEMFKLGYELTEKITSSNCAYTIST
                     SGSTGRPKTIAIEHKSLVNMCYYSVKSISATENDICGIYLSFSFDAVMKQLFPYLLVG
                     ASIDIMPEEAKFDEYTVNEYCEENDITILALPTAFARLFIQNCNNNSLRVVQTGGERL
                     KGYRKRNYELYNEYGPTEFTVVSTSFHVDREYGKIPIGKPIFNTYAYVLDKKNKLCPI
                     GAPGELCLSGIQISRGYLNKKGLTEQVFVENPYKTCEHNKLMYRTGDLVRWLDDGNLD
                     YIGRMDNQVKIDEFRIELYEIENIINNITEIKSVVCISRTNDDGDMYICAYYVIDEED
                     SGKINERTIREYLNEHLPPYMIPTIIMRIDKIPVTPIGKVNKRALPE"
     gene            22963..23694
                     /locus_tag="KR257_000394"
     CDS             22963..23694
                     /locus_tag="KR257_000394"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861199.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycerophosphodiester phosphodiesterase"
                     /protein_id="HBH0029121.1"
                     /translation="MNIYAHRGFSGKYPENTILAFKKCLDMDIYGIELDVHRTKDGKI
                     VVIHDEKVDRTFNGHGFVKDFTLRKLKTLNSSFEGYQSNKECKIPTLEEVLILISPTD
                     LILNIELKTDKINYPNIEKDVLELILKYNMKNRVLISSFNSNSLKNFHKLDPSIKTGL
                     LCYLPINNVVNFAKFLGNSYLHPPLVLVNESLIELCHKNLLGVNVYTVNEEGDILHCL
                     KLNVDGIFTNYPDIASNLLHSKQYS"
     gene            23774..24409
                     /locus_tag="KR257_000395"
     CDS             23774..24409
                     /locus_tag="KR257_000395"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861198.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cysteine hydrolase"
                     /protein_id="HBH0029122.1"
                     /translation="MDNLLNELEALKSNLDNLPIEKIENYDLSKTALFIIDVNNGFAR
                     QGALYSPRVESLIKPIEMFTKKISNKLNRVIAFTDSHTPKSIELLSYPVHCLENDVES
                     ELVDELKSIENLQILPKNSTNGFFALENLDFDNIDNIIIVGDCTDICIYQFAITLKSY
                     FNQHNIEKNIVVPMNLVDTYDIPNVHPAEILNLVFFNSMIQNGVNVLKEIR"
     gene            complement(24660..25253)
                     /locus_tag="KR257_000396"
     CDS             complement(24660..25253)
                     /locus_tag="KR257_000396"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419758.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3867 domain-containing protein"
                     /protein_id="HBH0029123.1"
                     /translation="MSDDRIIDFNELKNKVKDSDVDKFEQYIYNLYFSVMDGKMSMAE
                     FSRKIFDYMRDNNISQEKFMKIQKQFMERYGMDTEEVEKQLRNFGIDPSTAGFMSNNT
                     SSKVSTEDLESFKKSAGFYEKYGEKIQPKSCITTFIKNDLNDINVIIDQEKIMLCSDR
                     KINLMDSELNEFLLEYKNMFNKKIKVVMCETTNKYDY"
     gene            complement(25324..26187)
                     /locus_tag="KR257_000397"
     CDS             complement(25324..26187)
                     /locus_tag="KR257_000397"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419753.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LD-carboxypeptidase"
                     /protein_id="HBH0029124.1"
                     /translation="MLGIIAPSGPLRNTSLEEIKFNLESYGYEVKFSESCSLNYKGYL
                     AGNDDIRARDIEDMFLDKDVDIIMCLRGGYGTTRILDKINYDIIKQNPKPFIGFSDIT
                     GLNLAFYKNCGLLPYHGIMAANVGKWGKFTYKSLVNALEFKDELYLENPKEEKIYTVC
                     EGKAEGIIMGGNLSLIIATMGTKYEIDAKDKILFIEEIGEPQYKLDRMLTQLYSSGKL
                     EECNGIIFGDFKDCIEENDLMELLIEFANKVNKPSIYNLQSGHCIPMITIPLGRMCEL
                     DATEKIVKLKK"
     gene            26350..27519
                     /locus_tag="KR257_000398"
     CDS             26350..27519
                     /locus_tag="KR257_000398"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902464.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amidohydrolase"
                     /protein_id="HBH0029125.1"
                     /translation="MLNIKTLCHEINDWVINIRRDLHKTPELGLEEFQTKKKIIKYLN
                     EIGINYIEYKNHTGITAYINVSPNFETVAIRADIDALPITEELNYSYKSINIGKMHAC
                     GHDAHTAILLGTCNILFKLKDYLNVNVKFFFQPAEETIGGAQLMIEDGCLEKPNVKYI
                     FGLHVNPNINKNLIELKYNTLNASTNTLQLTVHGSKCHGAYPHQGIDAIVISAHIITA
                     LQTIVSRNTNPTDSVVISLGKIEGGIKENIVCDKVVIRGTLRTLTPETREFSKKRIRE
                     ICDFTCKTFGGSISVEIEEGYPALINSNHLVDYVKQNAVELFGEENIILKDSPTLGAE
                     DFSYFLRHCEGAFYHLGCANREKNITSPLHTSTFDIDEDCLITGVMLHVKNVLSF"
     gene            27620..28096
                     /locus_tag="KR257_000399"
     CDS             27620..28096
                     /locus_tag="KR257_000399"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419749.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SAM-dependent methyltransferase"
                     /protein_id="HBH0029126.1"
                     /translation="MKEILINPIGKICIQGEEVFIKLDKKYVPALNELDDFSHLNVFW
                     WADGFDNPELRSILETPKPYKSGPDVIGIFATRSPIRPNPIALTAVQIINIDHENGII
                     KIPYIDANDNSPVIDLKPYTPSVDRVENPSVPKWCSHWPKSVEKSGEFNWEDEIEF"
     gene            28662..29456
                     /locus_tag="KR257_000400"
     CDS             28662..29456
                     /locus_tag="KR257_000400"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889182.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="M55 family metallopeptidase"
                     /protein_id="HBH0029127.1"
                     /translation="MKLYLSADIEGTCGIVNWDETKLECEFSQHYRTQMSKEITAACD
                     GATQSGVHEILVKDAHDSGRNINPNILPENVKILRGWTKDPLVMMAGIDESFDACIFT
                     GYHSGATCNGNPLSHTMDIDYDYFKINDEIASEFTINAYIAAYYNVPVAFLSGDEMLC
                     ESAKKLNPNIVTVPVSKGIGNGSISIHPNLALKKIEKGVKKALSGDLSRHLIKLPDKF
                     KIEIKFREHYKAFKASFYPNMKKIDSQTVLFETEDYYEFLRMLLFI"
     gene            29480..29923
                     /locus_tag="KR257_000401"
     CDS             29480..29923
                     /locus_tag="KR257_000401"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438483.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="regulatory YrvL family protein"
                     /protein_id="HBH0029128.1"
                     /translation="MIKISNKRRIPLGEFISVFLFFAVFFGITFCIFTVIGIGFLSFL
                     GFEYKSLGAVLIFFLIYFCITTPIDFLCTTILDIFRYVNKLPYSIYKLCEFIIDFILT
                     FLAMNIIDTFMDSVTIPLSTEILFALLSYLLSECMDFFDRDKKKP"
     gene            complement(30012..31298)
                     /locus_tag="KR257_000402"
     CDS             complement(30012..31298)
                     /locus_tag="KR257_000402"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438480.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Gfo/Idh/MocA family oxidoreductase"
                     /protein_id="HBH0029129.1"
                     /translation="MEKVKVAVIGAGNRGTYAYAPYIYENSDVCEIVAVAEPKKGRRE
                     LFTQKYNLDSKNVFETLEDFFKHDKMADAVIIATNDDRHYDVAKLALEKGYHVLLEKP
                     MSNSLDGLVHIDDLCDKYKDKIFMICHVLRYSPFYNKLKEIVESKKLGELVSIQYNEN
                     IGYWHFAHSFTRGNWRNSNETSPLILAKSCHDMDILLYLVGSRCKKISAFGSLKHLNN
                     QNASGEMAQNCLQCLVEKKCPYSAKRIYLEKDRSINRAVHINPTEENLLNILKTSPYG
                     RCVYRCDNNVVDNMVNILQFENGVTATFNLCAFTKENGRTIKLMFSHGEVGGDLNKNE
                     IRIKEFGKNEEIVMNPSNQQNMVEEYDRNLIAEFIKLVSNKELEKGRVAAKEAIQSHV
                     MAFAAEYSRVSDEVVYIEEFFDSAKQMTKEIEETIF"
     gene            complement(31516..32406)
                     /locus_tag="KR257_000403"
     CDS             complement(31516..32406)
                     /locus_tag="KR257_000403"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861195.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DMT family transporter"
                     /protein_id="HBH0029130.1"
                     /translation="MSSTIKSNRIKGIMFIIASALGFAMMSAFVKLAGDLPSFQKVFF
                     RNLVSAIIAFWLIIKHKGSLTGKKENLKVLLYRSIFGTLGVIFNYYAIDKLMLSDANM
                     LNKMSPFLVVIFCAIALKEKINVKQIGAIIIAFIGALFIIKPTFSVEVIPYLGGIAGA
                     VFAAMAYTCLRVLGDREDYYTIVFFFSVFSLVTVGPIAFAVYEPMTLMQLIYLLLGGV
                     FASLGQFGITLAYKYAPAKEISIFDYSNIIFSAILSIFLFNVYPDMLSVVGYLIVFSA
                     AFYMFLYNKKLDKLDKEKKK"
     gene            32698..33042
                     /locus_tag="KR257_000404"
     CDS             32698..33042
                     /locus_tag="KR257_000404"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896298.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RidA family protein"
                     /protein_id="HBH0029131.1"
                     /translation="MEIKRYEGTGRMSRAVVHNNTVYLCGQTHAEGGVIEQTTEVLAK
                     IEDLLNKYGSDKQHLLSVTIYLRDMKDFEAMNSVWDAWVEKGFEPARACVEARLAREH
                     LLVEMSVVAATK"
     gene            complement(33201..35297)
                     /locus_tag="KR257_000405"
     CDS             complement(33201..35297)
                     /locus_tag="KR257_000405"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896296.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CocE/NonD family hydrolase"
                     /protein_id="HBH0029132.1"
                     /translation="MIKFKLYISGLYSGNVIFDGDLLIEKLNPFTNKIESLKPISKEE
                     NTYYLNLTKIDLKSLFNNFDVYTKSLVNTDKDTVINNLGETHSKLNEYIWVQRNKKFP
                     LDIIIVDNKIVGFICLSRETCTILIMDGYEEYTVLKEWEKTHKNEEIYSIRFGGNYMI
                     DMKDGIKLSTDVYLPDFVDSAKKAPTILMRTPYGKENDKEIYYKYVQRGYAVVIQDVR
                     GRNESEGKWEPMIHEREDGDSTINWIVSQEWSSGIVGMLGASYLGYVQWAAASSGNKH
                     LKALVSIVTSGSPFIDIPRKGGAFVSGMLAWAFMVSRNKVDRSKMVRDDWDDVLNIRP
                     IENIPVEALGYRIEFLEEWLKRVEKDEYWDLMDWHLQKDKINVPALVVSGWYDDNSMG
                     TTEALDVIKDYEKGKRKAILGPWMHNSNTLRDINGISLGNSSLRYDLDYNYLLWFDKY
                     LKGIENNIDTTAPVEYYSVGSNKWKTEENWPIINKIDKSMYLISDGNANTSLGNGRLV
                     FDNDLEEKYDSYIYNPKDPSVQLIDMSENEVGVPNNYKDLEKRSDMLCYTSDAFSEEF
                     TVTGDIKLEFFASSSAKDTDWVIKIMDVDLDGNSIKLADGILSARFRNSFYKSEFMEE
                     GEIYKFTIITSKISNTFKVGHKIRLDITSSAKNFIFQNSNTTEGYNSIEYIEAKNTIY
                     HGGKYPSKLILPIENK"
     gene            complement(35310..36470)
                     /locus_tag="KR257_000406"
     CDS             complement(35310..36470)
                     /locus_tag="KR257_000406"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419720.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF819 family protein"
                     /protein_id="HBH0029133.1"
                     /translation="MNTLFSNPGSILAVMTSMIALGFYLQRYKAIKSLGPALTIIIMG
                     IILSNLKVVPVSTELYGTISTYAIPISMTIMLMSVDLKEMTKLSREPLIAIFVAVLTV
                     SIMAFLFGLVFAEKISEGWKVAGMFVGTYTGGSANLTAIGTGLNVSRQTLAAANAADY
                     VIGVPTLIFMFALPAILKNSKKFKKLWPYHVEESELEDCQNEEFMESKEWSIKDIAWM
                     LAIGFVVTEVSTILAGYFNSSFSSAARILLVTTISIIIAQLKPVKKLKGNLDLGLFVA
                     LFFLCTIGFSVDIKEFLGSTFTITLYCFSIIFASFVFHLGITRLLKIKYQYVILSIVG
                     AIADGPTSALVAASAKWNSLVSVAVVMGVIGGVLGNYAGISVAYAIKMSLGL"
     gene            complement(36489..37556)
                     /locus_tag="KR257_000407"
     CDS             complement(36489..37556)
                     /locus_tag="KR257_000407"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902456.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dipeptide epimerase"
                     /protein_id="HBH0029134.1"
                     /translation="MKITDIKFEKLRIKLKKPVVVSFGVIEYGESIILKIETDEGYCG
                     FGEAAPLAAVTGEVLDNVLSVLLMFKKELIGKDPLDIETIHTIMDGIIIGNTSAKAAI
                     DIALYDIKGKIMNAPLYKVLGGFDSKVQTDITISIDKPEKMAVEALERVKEGFRILKL
                     KAGINPEDDIEAVKLIREAVGESIRIRIDANQGWNVNSSINTIKKLEEFNVDAIEQAL
                     PHWDLDGTAYIRNKSNTKIMIDESLHSPIDAIKAIKKNAVDTFNIKLMKSSGIYPAIK
                     INNIAEASGVNCMLGCMLETRIGITAAANLIASKKNITEADLDSFMFCEELEGISGGF
                     VMDGDIMNLVNKPGLGIEVNL"
     gene            37908..38474
                     /locus_tag="KR257_000408"
     CDS             37908..38474
                     /locus_tag="KR257_000408"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428136.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HBH0029135.1"
                     /translation="MLGEKMRNIRKSKKKTLSDVSKLTDLSISYISQIERDAIEPSLS
                     SLRKIAEVLDTPLYMFMDDNNTDDLVIRKEDRVMMKFPKSEMFYEIVSPMPTTEFTPS
                     ILFVEFELKPESEDAKDYIYHASEEIMVVTSGVVDICMGEKVVRLNPGDSTFIKANVP
                     HKIINPSKDTIARGYGVISPPIWPIKSK"
     gene            complement(38669..39655)
                     /locus_tag="KR257_000409"
     CDS             complement(38669..39655)
                     /locus_tag="KR257_000409"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896290.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="biotin-dependent carboxyltransferase"
                     /protein_id="HBH0029136.1"
                     /translation="MGFKVELGGFQTLIQDRGRVGYGQYGVSGCGAMDEYAHRVGNIL
                     VGNSEDEASLEVLMLGPTITFDEYTQIAVTGGDLGAKINGKEIQNWRSYQINPGDVLS
                     FRGVKSGARAYVSIAGGIDVPLAMGSKSTYTRAKIGGFEGRALKKGDYINTFIQEKDF
                     TINKKLSSKYIPTYSSEIVLRIVKGPQFDAFSNGEVEKFLSNKYKVTNEIDRMGCRLD
                     GESIKHLNGADIISDGISYGAIQVPGHGKPIIMLSDRQTSGGYTKIGNVISVDLYKLA
                     QAKPNDVVKFELVDIYEAHRLLREQEDKIQDIYKSMKNIRVVKAKVLNDIAV"
     gene            complement(39685..40380)
                     /gene="pxpB"
                     /locus_tag="KR257_000410"
     CDS             complement(39685..40380)
                     /gene="pxpB"
                     /locus_tag="KR257_000410"
                     /EC_number="3.5.2.9"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889166.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="5-oxoprolinase subunit PxpB"
                     /protein_id="HBH0029137.1"
                     /translation="METRYLISGDKAVVAEFGNEISEDINKKVISFMRAIEISNLKGI
                     VTEMVPTYRSLMISYNPLEIDFDSLIENLKKIEDNLESIVLPKPKIHEIPVCYDEVFG
                     IDIKNVASYNNLTVDEVIKIHTSREYLIYMLGFTPGFPYLGGMDERIATPRLEVPRTK
                     IYGGSVGIAGSQTGVYPIDSPGGWQIIGRTPLKLYDENREEQILLRAGDFIKFVPITL
                     DEFIEIEKNNLSI"
     gene            complement(40400..41620)
                     /locus_tag="KR257_000411"
     CDS             complement(40400..41620)
                     /locus_tag="KR257_000411"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419704.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="divalent metal cation transporter"
                     /protein_id="HBH0029138.1"
                     /translation="MSTKNITDKTKNKKDVGALIGAAFIMATSAIGPGFLTQTAQFTQ
                     DFGPNFSFVILITTILFIGAQVNVWRVIGVSGLRGQDIANKIIPGLGYLVAFLVALGG
                     LAFNIGNVGGAALGMNVMFNMNMTLGTVLSGLIAIFVFMSKNSNSLVDKITKFLALGM
                     IIIVGYVAISNHPPVGEAVSRMVKPENPKGLIFPIITLLGGSVGGYITFAGGHRLIDG
                     GITGEENIKEITKSSLLGILVATMMRVLLFLAILAVVSKGLQLDPENPAASAFKFSAG
                     AIGYKFFGLVLWSAAITSVIGAAYTSVSFLKTLNPFIDKYEKYFIIAFIAISTLIMAF
                     IGKPATLLILAGALNGLILPITLGIMLIASKRKDIVGDYKHPTWLLIFGLIVVLISAY
                     TGITSLSSLGALFA"
     gene            complement(41649..42440)
                     /locus_tag="KR257_000412"
     CDS             complement(41649..42440)
                     /locus_tag="KR257_000412"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896287.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LamB/YcsF family protein"
                     /protein_id="HBH0029139.1"
                     /translation="MYKVDLNSDLGESFGTYKIGLDEEVLKYISSANIACGFHAGDPS
                     HMEKTVQLAKKNGVKIGAHPGFLDLIGFGRREMKITKQEAKDYTKYQLGALMAFASSN
                     GCNIQHVKPHGALYNMAAKDKELAMGICEAIYEVDKDIILLGLYNSEMINSAKEIGLR
                     FANEVFADRAYDNNGFLVPRNVEGAVIHDTKHAIDRVVRMVKEGTVETLTGEVIHIKA
                     DSICVHGDNPKAIEFVKEIRKRFELESIEVCPLENIEVCSSENIV"
     gene            43028..43657
                     /locus_tag="KR257_000413"
     CDS             43028..43657
                     /locus_tag="KR257_000413"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419696.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GntR family transcriptional regulator"
                     /protein_id="HBH0029140.1"
                     /translation="MDKNYTMPIYQKIALDIANKIYTGEIQEDSVLFGRSVLAGKYNV
                     SPETIRRSVKILEDIGVVKSIKGKGVIVLSPDKASSFIKKYRDITNISSYKSTLYNLI
                     DTKSNLENEILDTINKILDYSNRLEIINPLVPVQFTINSNCKYIGQTAAQTKFWQNTG
                     ATIVAIKRGEELIISPGPYIEFLEGDILLVVGDQHIYNSIPMFLYENEK"
     gene            complement(43771..45285)
                     /gene="glpK"
                     /locus_tag="KR257_000414"
     CDS             complement(43771..45285)
                     /gene="glpK"
                     /locus_tag="KR257_000414"
                     /EC_number="2.7.1.30"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009905427.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycerol kinase GlpK"
                     /protein_id="HBH0029141.1"
                     /translation="MEKKYVMALDQGTTSSRAILFNKKGEIVKIAQKEFNQIYPKAGW
                     VEHDPMEIWGSQSGVMREVIETAGIRPEEIASIGITNQRETTVVWSRYTGKPIYNAIV
                     WQCRRTSEICDELKNKGLEESIKEKTGLLIDAYFSATKVKWILDNVEGAREKAEQGEL
                     LFGTIDTWLIWNLTRGKVHVTDYSNASRTMMYNINDLEWDEDILRELDIPISMLPLVK
                     PSSYVYGHTDERMLSGAKIPIAGCAGDQQAALFGQNCVEEGTAKNTYGTGCFLLMNTG
                     SNIVKSKHGLLTTIAWGVDGKVTYALEGSIFIGGASVQWLRDELKIIESAKDSEMYAN
                     RVEDTNGVYVVPAFTGLGAPYWDMYARGSILGLTRGAKKEHIVRATLESIAYQTKDVL
                     EAMQNDSKLKLKSLKVDGGASNNNFLMQFQSDILNVDIDRPKIVETTALGAAYLAGLS
                     VGFYIGRNEITSKWSVEKEFNPNMSEEKRCKLYKGWKKAVSRALSWEKEDELDI"
     gene            45529..46071
                     /locus_tag="KR257_000415"
     CDS             45529..46071
                     /locus_tag="KR257_000415"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861191.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="HBH0029142.1"
                     /translation="MPKILENVKEDILKVSRDMILEEDYSNISIRKIAQRCGISAGTV
                     YNYFNSKQEIIEYITKSEWDLLIRRIEYSNKNTEDYIKKLNIIFTEIRNFINKVHNIQ
                     YNDFLNTFETERFFEMKKHKDDFHEQLSNKVYEALEKESFFNNDKLVCNIIIKMFFSY
                     STYLHIEFEDLKPYIEKLIH"
     gene            46085..48577
                     /locus_tag="KR257_000416"
     CDS             46085..48577
                     /locus_tag="KR257_000416"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896283.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MFS transporter"
                     /protein_id="HBH0029143.1"
                     /translation="MNHNTSIKNKDSNPKIFLVLTLYLLGIFMGAIDTGIVSPARTII
                     QNSLGVNEKTGIWMITIYTLTYASVIPISGKLADKIGRKYVYLVSIFLFGSGSLICGL
                     SSLFSNFYILLIGRVIQAIGGGGIMPIATAEFGTTFPENKRGMALGLVGATYGIANIL
                     GSSIGSTILSIFGTQNWKWLFFVNLPICLIILIGGVFCIKNNKSESKEKIDKLGTLML
                     ICIIVSLLYGLMNIDFFNFKNSIQDISVYPYLLTFIVLIPIFIFIENRAKDPILSFEY
                     FLNPRILIVLILSLIVGIGMMGMVFVPQYAENALKINAGSGGYFVAILGLFAGIAAPL
                     SGRLIDKFGAKKILLLGFSVSMIGSLYLVLIALKTNTVFSVCVSLIFMGLGMGFTMGT
                     PLNYMMLSNTRLEESNSALATLSLIRSIGTSISPAIMIGFIAHAGLSVQDNIMDLVGK
                     PSTPKIVQLEELENMIDDLKSDPEMAKNLKNVSIPNMNDTSNINMDMTGGKLPKSLLN
                     KVQSADTTNITNITKEISTTMFDEKVPSIITKIQKNVQKGIDGTQSGINGIEDGENKL
                     NSGIKGVQTGIDNMVKARAGINQGIDGVKKGIAGVDKGIKGMEQGLEKQDEAIKELTT
                     AYNKIPTTEKTPTDNENNSNEQNQSNTSNSESDDTKNDSTENKNNNSSENKPNVNEQK
                     ESLNAQIQQLKKTRDDLNTKLQKNKTQKNELSKKLRSMESQKKELQSKLNNSISQKKD
                     MEKSLDTMQQQKKSLQAVLAKTQEVKTEIPKAFDKSKLDYINSIENNRTKIENTLQST
                     LNSGFKQMYITVFCVNLLAFIILLFYKENKTR"
     gene            48998..49396
                     /locus_tag="KR257_000417"
     CDS             48998..49396
                     /locus_tag="KR257_000417"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889162.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="HBH0029144.1"
                     /translation="MDTLGKRIAYLRNSKKLTQRKLMDILKFENLGKYETGDRKPNCD
                     ILMSIADYFNVTTDWLLYGKEKVNVNSSVKEDKEDYLHVTNDEMTILNLYRQLNERDK
                     IKIEGILELKISEYKDLKKHSSNNNEDKMV"
     gene            complement(49613..49822)
                     /locus_tag="KR257_000418"
     CDS             complement(49613..49822)
                     /locus_tag="KR257_000418"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009905424.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0029145.1"
                     /translation="MCKLDSDGVIECCRAIDDFITALSNIKSLNMERLNTLTKYSSTC
                     SILLKEGNYEGCTIVYRKMLEELKT"
     gene            complement(49854..50063)
                     /locus_tag="KR257_000419"
     CDS             complement(49854..50063)
                     /locus_tag="KR257_000419"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419680.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HBH0029146.1"
                     /translation="MDARKKWIPFLGVQVKQRLIELNMTQRELAKKIGVNENYLSAIL
                     NGRRTGKKYKSSIYQLLNIEYSEDD"
     gene            50362..50781
                     /locus_tag="KR257_000420"
     CDS             50362..50781
                     /locus_tag="KR257_000420"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428147.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HBH0029147.1"
                     /translation="MDTLGERIVYLRKAKNLKQYELEEMLGCDNLSKFERNIRKPNYE
                     ILKSIAEIFNVSVDWLLNGDNLSHKSDLICDSSSNYPLNSINSNEIKLLNNFRKLNDY
                     DKAKIEGMIELKLHEYEKEKDLGKIEYNKNKDEKIDK"
     gene            51009..51464
                     /locus_tag="KR257_000421"
     CDS             51009..51464
                     /locus_tag="KR257_000421"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419674.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0029148.1"
                     /translation="MGLRDKFAQSFARSKTMSGPEKKANEIMGKLLLKKAILPIVLMF
                     VIIIAGAMLKINSWVTLGINLVIAVGAFFYIRNSSKKYQNFKPYVGNLISLEKKGKKE
                     YVAIIKQGKLPVKLQIAYGGEDLEHVKKNQMVQISYNPDAKIAILVNRQ"
     gene            complement(51671..51931)
                     /locus_tag="KR257_000422"
     CDS             complement(51671..51931)
                     /locus_tag="KR257_000422"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438465.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0029149.1"
                     /translation="MDKLITELSSLGAIGILCALLFKNTMQEKKEDRDMYKKTVENFI
                     ELSTQQQEINKNILVQMGIMKTDVEEIKEDVTDIKGMLQNGV"
     gene            complement(52194..52547)
                     /locus_tag="KR257_000423"
     CDS             complement(52194..52547)
                     /locus_tag="KR257_000423"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419667.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0029150.1"
                     /translation="MFKFDKNKIEQIKQGRKVEMQYKDISDISIGQVKQDDDITNNFI
                     ANVEIYEMLLNQSSVNEASNISTFSVRKSGGESGMVEVYVALILRGKKTIEEVPAVIR
                     EQVRIRCKELEIPVE"
     gene            complement(52564..57885)
                     /locus_tag="KR257_000424"
     CDS             complement(52564..57885)
                     /locus_tag="KR257_000424"
                     /inference="COORDINATES: protein
                     motif:HMM:NF012632.1,HMM:NF024930.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0029151.1"
                     /translation="MKRTKLLQRGNFFGDKNMVVDEFDEGYDNYDFINFFTGCCNYTF
                     GLKNNNILYGCGDNSNFQLGLGEDNTTRKLFTKIPNISTNIKKVACGESHAVILTSDG
                     ELLVAGINTDGQMGLGLEKVGKTVSTFEKVPEIKGVKDIACGLQSTYLLYNDGTLYVA
                     GNNLYGQLGLGTNGASANVNTFTKVDVDNVKAVFSYNKSAFIIKNDNKCYSTGFNNQG
                     QLGLGDKNNRDLFSLVSINDVKTIACGSEHTVLMTYNNDIYGCGKEKCFGNALQSSLF
                     TKIEEVNIKTIACGHGNTMLIDNKGTLKVAGNNDIYQLGIANYSENIDNSFIDLKNIV
                     AKNIFIGLSHSILIDSNNDSYCTGDNTYGQLGSFFDDMHIVEFKKMDSEKYSYSNYIN
                     LIKSEDKLTLLKEEMEIKDIELPLDIHSVRDVVFSPYCTLVILGNGDVYGLGNNRYKG
                     MGSDLPSQLNELTKLSISNVKSIVASKNISGGIFYIKNDDTCYYSGPNSNSIAGVLPS
                     NSDVFKKISIDNVKKVVINTDLSNWFSLIVTNNKQIYTSGKSSSYVNGLSNALISQYT
                     EISLSNVTDAYSSYNATFIVVDEKKVYATGINTNYLLGFSTSDGSNVNLGLLSDWYYI
                     NISGSSYSRVSCTNNITKINNIIIYEYVTVFCTNIGSFLTGYHGTSWTKPTDSSYRVQ
                     YQGISYAGYLDSYIYNYYPTRCTQSSSSTTFAYLYNGESSSNLKNVNPDNLLISGGSS
                     YIHQYGRNYLNNQSSNNIAASNINSGPITSDKAIFLYKALLYLSSNTLYGFGNISESA
                     KELDVSDTQDGYNATNYKKVMKNIKNIFIPPYDLSRDKTRFAILTDKSLFICGYNSKG
                     THGISVNSSLNLNNKINYNKKNSSSEISSNIQEIYSHSKSTYLLTNNNMLYSVGLNDV
                     GQLGVGDEINRKVFTKINIDNIKSINVNRFTDNSKHAFAIKNDNTCYAVGLNNSGQLG
                     IGDNVNRNIFTKINVENVKYVAVYGNTSLLLTNDGLLYGAGNNGKGQLGLGDTTSRNI
                     FTRIPINGVRDVYLCNDVSIIVKNDNTCYVCGLVNGYFGFTEGSISTFTKINIENVKS
                     VVTAGSEATFFITNDNMIYTTGKKERVFFSTETNDIKGIRVINNIINAKKIVVNGYTS
                     AILTNDNKLFVGGLSGYGSIANNNNTNSVEDVKDVFVTANNTLYIDNNNNLISSGRDT
                     YGISDESYRDMSVPYYKVSIKKDVDTVFSSYNTIFIKDIYGKFYSSTGDNRYNHLGIH
                     HRYDNDKNEALEGSLHSYFKTDNTSDKIVFNKKNEKLVMFNDKYIKTNNKYINYKNIF
                     KDNFKYTSIILPFEVSDIDISKTHSLAVAKDGKLYGIGSNSYKEINQTLEDIELLTLT
                     EVNISDVKKVACGDNYSYIIKTDNTLWSYGKNTEYQLGVGHNNDVRELQKVTGLPSVK
                     DISIYNSMTLVLTNEGELYAQGYNTNGLFGLGESEKDKIIRTFTKVLTNVKEIKSHND
                     DHILVIKNDNSLWITGKNKSMYKISISITDLYEFTKIPIPEHLNDILDIELSDDTIYM
                     ITKVDTSKASIEIVEKSISQVRVVVQDPNNVIEKLEMFINDELISTKTNLEINSIIFE
                     IPQNKIVLGENKILIKASSPTGDLYSSMFIFKSETGLKVKKDSILMINNKVYSIINIT
                     ENNTDLIVTLNEGLKDDMMENNPIYQLINKTKVQVKINKSDLFKDMKLVEIKKSDSSY
                     QEIYELEEANIKSAQPKIIVEKGDKWTAIKRPSMIFRYDAENNEPQA"
     gene            complement(57902..58885)
                     /locus_tag="KR257_000425"
     CDS             complement(57902..58885)
                     /locus_tag="KR257_000425"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889153.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phage tail protein"
                     /protein_id="HBH0029152.1"
                     /translation="MEEKFYIILTKIGREKIANATALGELVGLTKFQVGDSNGEYYEP
                     TEEQTALKNVVWEGNINSLRIDEKNPNWIVIETILPGTVGGFMIREAAVLDNENNIIA
                     IGKYPETYKPRAEDGSIKDLVVKMILQLSNTSNVTLEVDPTLVFVTQKDIQDLDDKFD
                     KNIKEIKVKIGEELLSTEAKNLSGAINEVVEKIKNISIDDVIGGQIQTELSVLKNSYN
                     KLSEKVLDILIYLELESEIDVDEAGYWYDTLTNAKNIIAIEGLKLDLNRKCITGELGS
                     VTFKNVVLPFNANRVRYIHEMDNNFVETKSNRAYSIGQTDITLNKYSYEIR"
     gene            complement(58886..59584)
                     /locus_tag="KR257_000426"
     CDS             complement(58886..59584)
                     /locus_tag="KR257_000426"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428156.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF2313 domain-containing protein"
                     /protein_id="HBH0029153.1"
                     /translation="MKLIDKLPSFDRNYIVEEIQGAYDTELNILKEDIDDTFNQLFVD
                     TATWGLDMWEDILCIEKKELDFDTRRSNIKAKMRSRGTSTIEVIKSICEAYTKSETDI
                     KVYSDEFTFVLSFIANNCDYKTLLDCSDMIERVKPAHLLHYLEPIILDKSMVYCGGGM
                     VCSEEVKVHPYFEPIIKCSAVVNCGAGMISREEIKVYPLSIKCIENNCKINIAIANDT
                     GVENVVVYPKSEVV"
     gene            complement(59581..60633)
                     /locus_tag="KR257_000427"
     CDS             complement(59581..60633)
                     /locus_tag="KR257_000427"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428158.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="baseplate J/gp47 family protein"
                     /protein_id="HBH0029154.1"
                     /translation="MYSDQTYEVIKNRTLENINLDIYKGEGSFLNNMVSGNNLELSKI
                     YLELSKMHKMAFIQDTYNQFLDKRVNEFGVYRKLGTESNGEVEFIGEKGTVINNGTII
                     SYRDLLFVVIKDVTIGSEEGDNSPVQALEVGKKYNLPTNCEFKLVDNISGVTKITNTR
                     SFEGGTDIETDEELKERFYKIQRNQATSGNKAHYEEWALEVDGVYNVKVYPRWDGPGT
                     VKVLIFGKNNQAVDTETIERCQQHIDEEKPIGPTITVVTPLPIEISISAVMKLEDGYT
                     LDNVKESFLESINTYFRDIRGEIIYTKVMGILINTTGVHDLSNLLINGSTDNITINED
                     KIPSVTTVNFSEVENQ"
     gene            complement(60626..61054)
                     /locus_tag="KR257_000428"
     CDS             complement(60626..61054)
                     /locus_tag="KR257_000428"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419656.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF2634 domain-containing protein"
                     /protein_id="HBH0029155.1"
                     /translation="MSTIFPFIGVPEDYILPKTEELPIFREVAWDFEKDEPILEKGDF
                     KIIEKKEALKVWIYKCIKTNRYEHEIYSLEYGTELSELIGQKYTKGLTESEASRFIKE
                     ALLINPYILEVNVKSANFNRDILSANVKVSTIYGEVEINV"
     gene            complement(61054..61380)
                     /locus_tag="KR257_000429"
     CDS             complement(61054..61380)
                     /locus_tag="KR257_000429"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438447.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF2577 family protein"
                     /protein_id="HBH0029156.1"
                     /translation="MANPINEFIGIIREEGKYHNQPSFFIGKIKSKLPDLKIETNNII
                     LEKEDILIDSWMIDRQLETFDTETNQEHQHEVKNPFIDNFESGDMVIMFRIGEKFAVV
                     SKLVSL"
     gene            complement(61396..62925)
                     /locus_tag="KR257_000430"
     CDS             complement(61396..62925)
                     /locus_tag="KR257_000430"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419653.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="C40 family peptidase"
                     /protein_id="HBH0029157.1"
                     /translation="MIINRSKDSSSNEISFVSKDMGFLLTQSEVSYNFKDKLVEDIAK
                     QVFAENRLSVGIIAKTNVKYTKMFIGVNGYDTIMSAYTEASKKTKKKYMIEANLDKFN
                     VIEKGTVTLSVMFEEGFNIINTTFSESMENVKNKVIVVDQYGSKISEKIDNEIFKEVN
                     VIMQKVIQQQENQDVDIDSEFNGIEKSCSLKGYGDVSCITGRGVKVKDSYTKLVGLFY
                     IDTDKHTWQNGEYQIELELNFQNLMDEKSAGQDEPKEESNLGGEDYAGGKEFTAEFTA
                     YCPRKEEGGDTDCRKKKLDPSKKTCAAPMVGKYEQTYYTKEFLNKHPLLNYGDEIQVI
                     TGVSGRDGVYKVNDVGPAITIEKNGTYHIDILFGNVEEASKFGRRKGKIIIGGYSGNV
                     SDKAKIVISEAKKHLGKPYKWGGNGPSSFDCSGLMVYCFKKVNVSLPRTSNQQSKKGK
                     KVEQKNLQAGDLVFFHNPVSHVGLYIGNGEFLHAPQKGDVVKISKLSSRRDFNTARRV
                     L"
     gene            complement(63207..63629)
                     /locus_tag="KR257_000431"
     CDS             complement(63207..63629)
                     /locus_tag="KR257_000431"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889143.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0029158.1"
                     /translation="MEMWLRQAEDRFRFPVFPSSFSINGKAAVNSSSILKIGEIATFG
                     GVALKSISISSFFPNKDYTFCDYTGFPSPYDCVNKIEKWMKEGFILRFTITETNINME
                     VIIEGFSYEERDGTRDVYFTLDLKEYKRIKIPKVTPKQ"
     gene            complement(63629..66082)
                     /locus_tag="KR257_000432"
     CDS             complement(63629..66082)
                     /locus_tag="KR257_000432"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889141.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0029159.1"
                     /translation="MGNVREEGINMYLTDNYTPKMNQIISVTDNFRRATVAVSLSTNV
                     MASSIKNSIGSASNRVNSLNSSLRKVQTTASSVSSTMTKLSSSINAVSGVIGSLNGSI
                     MRLAITIAMIIDYFNKLIQKKNEFNSNIMIILIFKAKSDEVEKTKNKLLGNLKKIGGK
                     IWNIVIKAKDMTKRVISSILGKLKQVEKRPYQGSINLKDMVSSAMGRILPKLMLFKNT
                     FWSGVIAIKDMASGIISKVFPKLRLFAGKVWSGAIAVKDMASGILGSIKGKISDLTNG
                     ATIGVAVKKGVDLLGQEQNQKVVLESVMKRNTGKVNQIDVDDYYGSLVRMANDTPFDP
                     EDVVAMGTKAKMISNITGGKKEKDITQAMVDVRALNMNTSSEQDVSAAFLSAAKGNME
                     SLNTLVGENYKTFDEALEGISVKQMGLAKEMSNTIPGIISGAQTSINNGLKSIVKPFD
                     DILGQGLKKIKTFIESGLGNLAGLSEKMAGKIGNVMNGKIIIGNKYDQMQSRSVKNGK
                     EFSDSTQYRISNEAEKRKMMVENKQERFENHAATMIGNAPKAIVNAGSTLLQNIDFTA
                     LIDSLLPVVNLVNNLLDSINNKSPIAQGLISIFGTIVTTAFQLIGPVVEAVSPIITRI
                     FTFLGEYAPQINNFIETLGVIWKTVWETLGPLLETGWKIIEPILGAFFNILDKVCKIV
                     KDICKWWQTMINKIKNGSITGTVLNLVEKSKKNYKDNPYAGTKAGDSGKAYSGKKGNN
                     AFGLNYVPYNDYQTRLHEGEMVLTKQEANQYRSRKNGGNINIAKLADTIVIREEADIE
                     KITSKLVASIQLAQLGGVL"
     gene            complement(66082..66249)
                     /locus_tag="KR257_000433"
     CDS             complement(66082..66249)
                     /locus_tag="KR257_000433"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428173.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0029160.1"
                     /translation="MYYYWKKKGIRPSLFYAMDKGELKLIEAFFALEIEEEVEKMKHG
                     YGVCPLTGGGM"
     gene            complement(66276..66722)
                     /locus_tag="KR257_000434"
     CDS             complement(66276..66722)
                     /locus_tag="KR257_000434"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428176.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phage portal protein"
                     /protein_id="HBH0029161.1"
                     /translation="MSENGLSKNINIVDLLLNSDTENLERPSTIVELKRLSTIFGQEF
                     KVMCRALTISKDEEIQNTCLKIDENMKTDIDLPEMQMLTIIEGVCDLDGKLLFKNKEL
                     MDKFKAPTPKELARKLLLPGEITNLYRILQDVMGYGKNAVIEEVKN"
     gene            complement(66836..67264)
                     /locus_tag="KR257_000435"
     CDS             complement(66836..67264)
                     /locus_tag="KR257_000435"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896262.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phage tail tube protein"
                     /protein_id="HBH0029162.1"
                     /translation="MANMEARNVMSGTWGELWLDGNKVAEVKKFQAKMEFTKEDIIIA
                     GQMGTDTKYMGYKGKGSITLYHVSSRMHKLIGEKIKRGSEPRFVAISKLNDPDSYGAE
                     RIAVKNIAFDDLTLADWEVGVKGEIEAPFTFTEYDFLDII"
     gene            complement(67278..68342)
                     /locus_tag="KR257_000436"
     CDS             complement(67278..68342)
                     /locus_tag="KR257_000436"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861188.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phage tail sheath subtilisin-like
                     domain-containing protein"
                     /protein_id="HBH0029163.1"
                     /translation="MAIGLPSINISFKELATTVKERSARGIIAMVLKDAKALGLNEIH
                     EKEDIPVDLSAENKEYINLALMGNVNTPNKLLVYVIEGEADIQTALDFLETKEFNYLC
                     MPKAVEADKTAIKNWIIKLRDIDKVKVKAVLGKVVGNHEGIINFTTEDVLVGEKKYSV
                     DEFTSRVAGLIAGTPLSQSVTYTKLSDVVDIPKMTKVDAESRVNKGELILIKEAGAIR
                     IARGVNSLTELTAEKGEMFQKIKIVDTLDIIHSDIRKVIIDDYIGKVTNSYDNKCLLI
                     VAIKSYLEELEKSALIESDSTVEIDFEAQKSYLKSKGVDLSYMTLQEIKEANTGSKVF
                     LKAKIKVLDAMEDIDLSIEI"
     gene            complement(68347..68790)
                     /locus_tag="KR257_000437"
     CDS             complement(68347..68790)
                     /locus_tag="KR257_000437"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428180.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0029164.1"
                     /translation="MLKYKEILETIIEILKKNFTESIFIDDESVQGSEGSCFFVSILS
                     VICTPVMLNTNNKDIVISIKYLPKPQSKSIRMYEISDELNKLFNRNIKVTDRKLNITK
                     LEQSIKKEESIYVLNFTFTLNYLDSVYEEDVVYENMKEINLNLGE"
     gene            complement(69039..69479)
                     /locus_tag="KR257_000438"
     CDS             complement(69039..69479)
                     /locus_tag="KR257_000438"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419643.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0029165.1"
                     /translation="MENKKDILFKETDKRLHNYKYLDIKIKNINLDIKRCENEYSGCG
                     AMVYTEKTSNTYNISSSVENEVLKREERLRKLKMEKEDIEIEKEKIENALTCLNDIEM
                     EFFNLFYNSKTKNNMTYISMKLHLDRTSCYNLKKKMIFKLSEIL"
     gene            complement(69584..69781)
                     /locus_tag="KR257_000439"
     CDS             complement(69584..69781)
                     /locus_tag="KR257_000439"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419641.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HBH0029166.1"
                     /translation="MFKNNLKYYRKCKGMTQIQLARKAGITNDYISQIERGIKNPGLL
                     MAKKISSILEQNIEEVFFIQL"
     gene            69950..70270
                     /locus_tag="KR257_000440"
     CDS             69950..70270
                     /locus_tag="KR257_000440"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428185.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="XRE family transcriptional regulator"
                     /protein_id="HBH0029167.1"
                     /translation="MFAKRLRELRKEFGLTQRELGEKVGVSQRVLGYYETENRFPDEH
                     ILNKLADVFNVSVDYLLGRTLVKENIDTVAAHRKNPHEELPEEAQEQLNDYIEFLLNK
                     YKKK"
     gene            70352..70858
                     /locus_tag="KR257_000441"
     CDS             70352..70858
                     /locus_tag="KR257_000441"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419636.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0029168.1"
                     /translation="MNNLDKLFELASQEEIIIHYTTYIAGDLEGLYINKHGIKIISLL
                     SNLKQNSKKLTSILAEELGHHFTSLGYYVSSYNDYYTKIIIDKCENKALKWACEFLIT
                     EEDIINIINSGITCVYEMADILNVDITFFQKRLEFLSLKKQSLQLGNNKYLILTNLPY
                     FYIFDPIS"
     gene            71559..72314
                     /locus_tag="KR257_000442"
     CDS             71559..72314
                     /locus_tag="KR257_000442"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889131.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptidylprolyl isomerase"
                     /protein_id="HBH0029169.1"
                     /translation="MEKKVLATVGEKEITNIDIENALKSLDPYQAMQFKTEEGKKHLL
                     NDLVNQELFFLDAKEEKLDEEEIFKLEMKKIEENVLKQFAINKVLSSVNVTEDEKVKF
                     FEANKSSFSKPESATAKHILVDSDEKAKEILAQIKSEEISFEDAALKHSSCPSKDMGG
                     DLGTFGRGQMVPEFEEAVFSMAKGEVSEPVKTQFGYHIIKLEDLQESTESTFDEVKAE
                     VEKSLLYQKQNEVYGNKINALNAKYGNLVKYND"
     gene            complement(72457..72885)
                     /locus_tag="KR257_000443"
     CDS             complement(72457..72885)
                     /locus_tag="KR257_000443"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889129.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CBS domain-containing protein"
                     /protein_id="HBH0029170.1"
                     /translation="MNILFFLTPKSEVAYIYEDYTIRQALEKMEYHKYSAIPIISKDG
                     KYVGTITEGDFLWTLKNDLNLDLKGLEDVPVTDINRKMDNSPVSINADIEDLVIKSLN
                     QNFIPVIDDQDTFIGIIKRRDVIGYCYEIIRGYKNLANDN"
     gene            complement(73306..73506)
                     /locus_tag="KR257_000444"
     CDS             complement(73306..73506)
                     /locus_tag="KR257_000444"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:YP_499930.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cold-shock protein"
                     /protein_id="HBH0029171.1"
                     /translation="MKTGVVKWFNNEKGFGFISVEGEGDVFVHFSAITGDGYKTLEEG
                     QSVEFEVVDGAKGPQAANVVRL"
     gene            complement(73689..74858)
                     /locus_tag="KR257_000445"
     CDS             complement(73689..74858)
                     /locus_tag="KR257_000445"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428190.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amidase domain-containing protein"
                     /protein_id="HBH0029172.1"
                     /translation="MGGVALKILKNKNKYIKGIMAFVFLSLATTAGVFLINDLSMKNM
                     EEKVMESANVEGDDVKDQYKLLLENLFDYRNKAILEKNENILKGLYETDKKFGLWAYE
                     NEVKKMKYLENWSSKQGVKFKDIKTRVKIKKIKEKEKDLYGIICSVSTEYKYSYENQK
                     DKENAFRIGTYHYLNVKIIDNQYVITKEWYTDPFADSLNLENIKSDDIRNYIGQQDGV
                     ELQLTDEQKKAIDYAHKYCGAAADEEHGMKFNPNYRDYNPEGGDCANFASQIMFESGR
                     FKKNSIWNYSERAGTKAWVNAQAFKNYALYSGRGSLIAKGSYEEVYKEAYNLRPGDFV
                     GYEKKGRITHVSTVTGLDSRGYPLVTCHNTDRMLVPWDLGWSDKSIRFHIIKINY"
     gene            75094..75915
                     /locus_tag="KR257_000446"
     CDS             75094..75915
                     /locus_tag="KR257_000446"
                     /EC_number="2.7.1.35"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428191.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pyridoxamine kinase"
                     /protein_id="HBH0029173.1"
                     /translation="MQKKVAAINDLSGIGKCSLSVAIPILSALKVQCCPFPTAILSSQ
                     TGYPEFTFLDFTDEMVKYSNVWKNLKVNFDSIYSGFLGSKHQIEIVANFINDYPNAFI
                     VVDPVMGDNGVMYPIFTEEMRHEIKELVKHSDLTTPNLTEACFLTGNDYTKSDYNRDE
                     LIYIAKSVSDLGPSKVVITGILEDDNILNLAYDRDNDHVFFTSVKYNNCSYSGTGDIF
                     TSILCGMLVNKHDLGVAVNTATDFIYKTINYTSQFDTDRNDGVMFENFLSDLTNI"
     gene            complement(75991..77379)
                     /locus_tag="KR257_000447"
     CDS             complement(75991..77379)
                     /locus_tag="KR257_000447"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861185.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="two-component system sensor histidine kinase"
                     /protein_id="HBH0029174.1"
                     /translation="MLGGKKSNNKKVEKLRTIFIKYLSLFFIMTISIVLLLMLSFSVL
                     LSSGVILPANYAEKQFNKYKEQIISSEKVTEDIIPSIYEYGVYTLDGSLISGTFNKKE
                     SKEVWNLMRDIEERHAYSESYIKFFKKDEVFIIKYKIVSEYSSPILRAYLPKPETLGM
                     IIFSIIFFIEIVILSKVFGKKFNIEMELLKNTTEKIEQQDLDFVVESSKIYEINNVLF
                     SMDKMKLALKDSLEKQWMLEENRKEQISALAHDIKTPLTIIHGNTDLLIEINENPELL
                     EYMEYISKGVTQIEKYINTLIDISKTENGYILNKEAISMSEFIKDVLVQIEALASTKN
                     LDVEFYKQDNLPKNITIDRELLFRAIMNIISNAIDYSPSQSKLYISVSVRNKYLKFVV
                     TDCGSGFSKADLSKATEQFYTGDLSRNSKSHYGMGLYIVNNIVQKHNGILYIENSVKT
                     GGAMVTIEIPIV"
     gene            complement(77514..78272)
                     /locus_tag="KR257_000448"
     CDS             complement(77514..78272)
                     /locus_tag="KR257_000448"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729590.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="lantibiotic immunity ABC transporter MutG family
                     permease subunit"
                     /protein_id="HBH0029175.1"
                     /translation="MRQLIRIFCSDLIKLKRNFIILMHICIALMGMGLFLWYYKVSGA
                     DNILKIVAYLQVIAIAFPLLSGVVCSMFVEQEYYAGNYKHMLTTSNPKYLTLISKYII
                     LVCLGFVATLVSVLGFKFGISKAYFASSFYMISILILIGCNLFEYILHLFLSLRFGKG
                     TSIGVGIVEMLLSALLLTGLGSGIWQYFPCAWGVRFITIWSSFSSSKTVEYIKVESIK
                     AYQSTGLMCGFVTILAFVILCIWFSKWEGKKSEE"
     gene            complement(78274..78990)
                     /locus_tag="KR257_000449"
     CDS             complement(78274..78990)
                     /locus_tag="KR257_000449"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729591.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="lantibiotic immunity ABC transporter MutE/EpiE
                     family permease subunit"
                     /protein_id="HBH0029176.1"
                     /translation="MERFIRVEFQKMKGTFGMKLIWIVPVFCILLCGLGGGQNAAFNW
                     WYTTFLPGALTLISSLIVLKDEKSKYRGILPLPIEMKDVWTGKMIYCIICCFIASIIS
                     AIGVVFVGIIYKETISIGQNIIATILIILLFMWQIPLCMFLASKFGIFVTVLINMFFT
                     IVGVAVFSTTEMWYMFPYSIPSRLMAVVLHILPNGLPVPEGSEFLNNAVILPGVLISI
                     VLFVLFALATRVWFNNREVK"
     gene            complement(78992..79699)
                     /locus_tag="KR257_000450"
     CDS             complement(78992..79699)
                     /locus_tag="KR257_000450"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902422.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="lantibiotic protection ABC transporter
                     ATP-binding protein"
                     /protein_id="HBH0029177.1"
                     /translation="MSNYILQVKGVSKKFKEQMAVDNISLAIKSNSIYGLLGPNGAGK
                     STLLKMITGILNPTSGKIMFEGHRWTRKDLSNIGSLIESPAIYENLTARENLKVHTTL
                     LGLPDSRIEEVLETVDLRDTFKKRSGQFSLGMKQRLGIAIALLNHPKLLILDEPTNGL
                     DPIGIEELRELIRSFPKQGITVILSSHILSEVEQVVDEIGIISNGVMGYQGEVSKEQN
                     LEKLFMKVVAENRKRGQ"
     gene            complement(79815..80351)
                     /locus_tag="KR257_000451"
     CDS             complement(79815..80351)
                     /locus_tag="KR257_000451"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419598.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="lipoprotein"
                     /protein_id="HBH0029178.1"
                     /translation="MNKIAVSFLIIATTLLSTACMDYSISAVELVDSKESAVVKKDED
                     AKEETTSKMINSKKTTKIPIEIISKDEKIVKYLQIDEESSLKDKLRLILDTLSNEYFN
                     GLDMEVEVKEKDNLVKINLIEPDKKSRVSWKDDYLNEQNIIYTINNIIKNVIQEEDNS
                     IWIEEVEIYYNGKLIELR"
     gene            complement(80453..81523)
                     /locus_tag="KR257_000452"
     CDS             complement(80453..81523)
                     /locus_tag="KR257_000452"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428197.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4097 family beta strand repeat protein"
                     /protein_id="HBH0029179.1"
                     /translation="MNKKLAIFAAVLLVIGIIGTTWSGILVMPSLINFGLEKEAEFKK
                     ENKLYQEKVNIDKLDIAVDNINVTIKKSSSEDVRVTTRGNNEFYKYNVTLKDKTLVVK
                     GERKYENKIKKIKNFDQLLNTSINSMFSHDYREIIIYVPNNVDINASSISSHLFVYDN
                     VASNTITYKTSYGGFSRAITENKVNRLENLNLISNNNLHLSTKSILGVKNVNIESESL
                     YISSENEDVFINNIEEYIPENVNIKEKIGRNSNYESEFYLYSDMPIAKFLDIEVPNSK
                     VRLDIPVNKYKFNCDIKSKEAIEEFNNDEEYDNDSYDYEHSEEHSNKYRNTREIKGLL
                     NKNLSNLEKEYTIKINSNSLEL"
     gene            complement(81516..82574)
                     /locus_tag="KR257_000453"
     CDS             complement(81516..82574)
                     /locus_tag="KR257_000453"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428198.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1700 domain-containing protein"
                     /protein_id="HBH0029180.1"
                     /translation="MNLNKTEFLEILKDYLKKDFSESEVNDILRDYEEYFVDGLIEGK
                     SDMEIIASLGSPKSIAKELILQTKEKNIEEEKIINTDVLNDKFSKFKSDMKKGYSILK
                     DEAKEKYSKSKENIDGKIMNTDILNGKFSRFKSNVKKDYSILKDEAKEKYNKSKENIN
                     DKLTPSIEEGVGGLSRQVIKGLLVVLSLFLIVPAFAFVCAIVSATIALVCSLIAFVIL
                     IPFVIKFIAMVPDVMMFCIFATIAFVGLEILAWQILLFAIKLGKQLLNNYIHWIKRKN
                     IYIKANEKMEKRKKATLNDEDLNKDINEDSYNNDYYNREEESIKETDEYNDDSINFEA
                     IYKDLEDIENKKGEDKHE"
     gene            complement(82561..82893)
                     /locus_tag="KR257_000454"
     CDS             complement(82561..82893)
                     /locus_tag="KR257_000454"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009905416.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PadR family transcriptional regulator"
                     /protein_id="HBH0029181.1"
                     /translation="MNTQFRKGVLEICVLALISKKDMYGYEIVHNISKVIDVNEGTIY
                     PILRRLTKDLYFETYILESNEGPARKYYRITSLGKENLSNLMEEWREFVKAVEILISE
                     DEGGNELE"
     gene            83092..84213
                     /locus_tag="KR257_000455"
     CDS             83092..84213
                     /locus_tag="KR257_000455"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438374.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="galactosyldiacylglycerol synthase"
                     /protein_id="HBH0029182.1"
                     /translation="MKDDKTILILTAQFGAGHISAAKAVKECIIEKYSNYNVVIQNFI
                     NASIPMMNKPMVKLYENNTKYTPGLYNYYYYFKKSFDSRHDLSHKLYTPKLSEYIADI
                     NPDLIISTFPLAAACVNNFKIKNPDINIPTLTVITDVVDSMEWVFENTDLYFVPSPEI
                     KNRFFQKGINPDSIKVTGVPVDKRFQIESKELCCDKYRLLLLGGGRGLFDIDEDFMHW
                     IDEFIEEHSNSIEITIVTGKNKKLYDNLTHKKPLKNIKVLGFVNDMYNLIRECDLMLT
                     KPGGATIFEAIQSQTPVLVKMPKVGQEIENAKFIIDKGLGMIYSDDLDLKNIFYKLVS
                     NEFDSIINFMKKNLKEFKTVIHPEKIADYISELIDNHYS"
     gene            complement(84341..86239)
                     /locus_tag="KR257_000456"
     CDS             complement(84341..86239)
                     /locus_tag="KR257_000456"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428202.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glutamine synthetase"
                     /protein_id="HBH0029183.1"
                     /translation="MDSLLYVIEKDKHTNEELREILKSNKNIRFVSLMGVDLGGNATD
                     EKIPVELFLEDIDKFLESAIQTDGSSVELYNIATLNNAKVDLMPDKSCHWYVDYNMEY
                     IDEEVGLPVGTLKIPAFLIHDNKKVCSRGVLQKADKYFKKSMYEIFREYPHVINNIGI
                     DSVDDIEEIMLTAATELEFWVNTPEDKADLEKLYVSQSLKEQYWKRTHGIIRTCLEKS
                     LIILQKLGVNPEMAHKEVGGIQSSISIDGRTNHAMEQLEVSWKFSTPLQAADNELLVR
                     DVIEDVFTSHGLEVTFKAKPIHGVAGSGGHTHVGVSAKLKDGSIKNLFAPKDLKEDYL
                     SELGYGALMGLLYNYEVLNPIVTASNDGFNRLVPGFEAPVCIVTSLGHSYEIPSRNRS
                     VLVGLIRDMKNPKTVRFELRSPSPLSNTYLVIAGCYQTMLDGIKAAAKSGLSTKELEK
                     ELSKNVGEESFYLEKDRAYRDENDVFEHYSLEERNARFGIPPATVYENMKNLEIYASK
                     LKSLKQGDVFTDSIIESFKIGAIDKWQKKLKTRIIEAGIQKIRSIVKIHTKENMDALD
                     EVVWNSISDLKFNIMKDTLTRESLFTRVREAIENKDYQTASDLQIELKRSMEEIQQLY
                     MQYKKNIY"
     gene            86554..87330
                     /locus_tag="KR257_000457"
     CDS             86554..87330
                     /locus_tag="KR257_000457"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889114.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="exonuclease domain-containing protein"
                     /protein_id="HBH0029184.1"
                     /translation="MEYIIFDLEFNQGFDKKLNKTVSNEKCPFEIIQIGAIKLDSKFN
                     IIDTFNSYVKPTIYKDIHPFISRMTNIKNSDFNDSPTFPEVYNNFIKFISSQDPILCV
                     WGAGDLKELYRNINYHKLPSNSLPKSYINIQQHASKYFNNPAGKSIGLQNAISILELD
                     EKMSYHNALNDAYYTAKVFIKIYNPSIVPDIYLYTSIKPKTIRYSNKKRVDYDKLFDE
                     FRKILNRELTKDEKKIINLAYNMGKTNQFTLENVKQRKNK"
     gene            complement(87422..88174)
                     /gene="xth"
                     /locus_tag="KR257_000458"
     CDS             complement(87422..88174)
                     /gene="xth"
                     /locus_tag="KR257_000458"
                     /EC_number="3.1.11.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428204.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="exodeoxyribonuclease III"
                     /protein_id="HBH0029185.1"
                     /translation="MKFISWNVNGIRACVGKGFLDFFKEVDADIFCLQETKLQEGQIE
                     LDLPGYFQYWNYAERKGYSGTAIFTKKEPLKVMYGINIEEHDKEGRVITLEFEDFYFV
                     TVYTPNSQSELKRLEYRTRWEDDFIDYLTKLDNHKPVIVCGDMNVAHKEIDLKNPKNN
                     MKNAGFTKEEREKFSKLLDSGFIDTYRYFNPDKEGVYSWWSYRFNARKNNAGWRIDYF
                     CASKKLEDRLVSADIHTEILGSDHCPVELEIK"
     gene            complement(88335..89285)
                     /gene="galT"
                     /locus_tag="KR257_000459"
     CDS             complement(88335..89285)
                     /gene="galT"
                     /locus_tag="KR257_000459"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438360.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="galactose-1-phosphate uridylyltransferase"
                     /protein_id="HBH0029186.1"
                     /translation="MKELRIDPITNDVVIFATDRLKRPLDTADIPNEDEETNEYDEEC
                     PFCKGNEAHATDALFEIESEEGWLVKSVYNKFPIIDDMARDVYGVHEVMIESDKHNRS
                     FYNMSQKEFEDVFFMYRNRFRDLSKDDKVEYVSIFKNFLRKAGASLMHPHAQILSMSF
                     IPPEITNELLVSKEYYDSNKSSLYDDLIENEISLDRRVVYNGEAFLVLIPYATKYSGE
                     VRIIFKDKIEFGELNDNNIQELSTIFEKLFKKLYNINGYMPFNLCIHTHPTKIETKSY
                     FNVHMHIIPRKYNFGGFELGTNMYVSSMSPEDLTKKLKID"
     gene            89670..90866
                     /locus_tag="KR257_000460"
     CDS             89670..90866
                     /locus_tag="KR257_000460"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419570.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pyridoxal phosphate-dependent aminotransferase"
                     /protein_id="HBH0029187.1"
                     /translation="MNYSNRVSAMQASPIRKLVPFAQAAKDKGIKVYHLNIGQPDIKT
                     PKGFFDAVKNFDSEVLEYATSEGIPELLEALQNYYKTYDMNFEKDELLVTNGGSEALL
                     FTMMAVCDPGDNLLVPEPFYTNYNGFGQSVNVEVNAVTTKAENGFHLPSKEEILSKVD
                     DKTKAIILSNPGNPTGAIYTKEELNILAEIAKEKDLWIIADEVYREFVYDGLEYTSCG
                     NLEGVQDRVIIIDSVSKRYSACGARIGSIACKNKGLIAQILKLCQGRLCVPTLEQIGA
                     VELYKTPVSYFKEVNEEYKKRRDVLYNELMKVEGVICKKPTGAFYIVAKLPVENAEDF
                     TIWMLKEFNKDNETVMVCPAEGFYATPGLGRDEIRLAYILNEKDLHRAATLLKEGLEQ
                     YVALQK"
     gene            complement(90978..92318)
                     /locus_tag="KR257_000461"
     CDS             complement(90978..92318)
                     /locus_tag="KR257_000461"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428207.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="6-phospho-alpha-glucosidase"
                     /protein_id="HBH0029188.1"
                     /translation="MKKRYNIAIVGGGSTWTPGLLKSLCKMSDRFPLNKVTMLDVVEE
                     RQRLIGEFGKILFKEEYPKATLEYTTNPDEAFIDVDFVFVQMRTGGLKMRELDEKIPL
                     QFGLVGQETCGAGGFAYGLRSIGDMIEMVKTVRKYSPKAWILNYTNPAAIVAEALKRV
                     FPDDKRLLNMCDQPVNLLRSYGRLLDMDSRTFEPVYFGLNHFGWFTHLYDKNGEDLVP
                     KIKDLVANSGFQPVDAEQRDKSWLDTYGMVKDMLEDVPDYLPNTYVQYYLYPDKKVAK
                     SNINCTRAREVMNGREKRVFEECKSVIEKGTSIGSNLVHNDAHGEFIVEVAEAIAHNK
                     HQIAIVITENNGAISNLPDDAMVEVAAILTKNGPRPLHVGNIPTFYKGLLEGQLAYEK
                     LAVDAYFEQSYEKAILSLTLNRTIISPTKARQVLDALIKVNKDYWPTLYKENEK"
     gene            complement(92457..93209)
                     /locus_tag="KR257_000462"
     CDS             complement(92457..93209)
                     /locus_tag="KR257_000462"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892977.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MurR/RpiR family transcriptional regulator"
                     /protein_id="HBH0029189.1"
                     /translation="MNLIDKLDINQKKLSTNEISLLNYFLKNSEKINQKKIKDIANET
                     FNSTAYIVRFCQKLGFSGYSEFKNFLVFSYSNRNERNKEFTKSQSDIFTDVMDTQNLI
                     NVENIDMCLNEIHNSKHIYFFGVGSSRLVCTEMSQRFSAIGVNVKYYDDSTLMYLAAS
                     NITKDDLVIAVSMSGETAQVIKACNIAKTNQVKVISLTNISVNSLSNIADIKLFVSSP
                     QYNFNSVNYTSRVPALSLMEYMFHKYIEKYNR"
     gene            complement(93357..94934)
                     /locus_tag="KR257_000463"
     CDS             complement(93357..94934)
                     /locus_tag="KR257_000463"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428209.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS transporter subunit EIIC"
                     /protein_id="HBH0029190.1"
                     /translation="MKQKMKGFFLQLGKSFLLPIALISAAGIFLGISSAFSNPNIVSD
                     MPFLANNFIQGILGFTKAITGVLFGNLAIFFAISISVGLAKEEKAVSAFSGFVGYLVL
                     HTSVNYMLGCRGIIAEPDMMREMGQAVTLGIQTLELGVFGGIVVGIITASLHNKYYNI
                     KLPDYLGFFGGTRFVPIITTVVFSILGIIIPYIWPYVNTIIQSVGIGIASLGYLGTFV
                     FGFLERLLIPFGLHHILNAMFRFTEVGGSLVVGGQEVFGALNIFLAQLSDPETISFST
                     EATRFLAQGKIPIMVFGLPAAAYAMYKTAKPENRSKVKGILLAGALATFVTGITEPLE
                     FSFLFVSPILFVIHAFLSGISFMMMHIFGVAIGNTQGGIIDLVVFGVMQPNTKWIYSI
                     ILGLVYAIVYYNVFKILILRFNLQTPGREEITDINFDLKPLSNKVEIAQSGETTKRAL
                     SIIKYLGGKDNIEDITNCITRLRVVVKDMSKVDENAFKKYTGAMGVIKVSDKDIQIIY
                     GPSVSQVRDEVSFAMSI"
BASE COUNT        32648 a        15325 c        11109 g        36196 t
ORIGIN      
        1 ctctttttaa atttctcagt tttccatgga actttacttt atttatttct gtattagttg
       61 tattttttat gcatttttct ttaaaatcat attttctgat tcaactctta tattataaaa
      121 tttctttact aaattattct ctttttctat atcttcatat atatttttta atcgcctttt
      181 acctaatctt ttatctaaca ttactaatga tttaactaat atattatatg attttatcgc
      241 atcttctatt gagatattta aacatatatt tactgcttca taaaaatcaa attcattaaa
      301 aaatccattt ttatttacaa tcttatatcc ctttgcatct ctttctaaat actcttccta
      361 aatactcttc aaaactttca tcatctaatc taaatcctat atcactatga aaaataggtt
      421 ttgcatttgg atatagttct attgttttat caaaagtttc gaataccaag ttattattat
      481 tcgattttcc aacagtccac tataaacaat aataagtttg ttgctccaaa taatgtaaca
      541 cttgtagaaa gatgttacag atatataaaa gatagagaat gtagtttttc tcctaatact
      601 attagaaata gaaaaaatat gattaaaaat caaattgaag ttttctttaa agatatgaaa
      661 ttaatagata taactccttc tattttacag tcttatataa ataacatata caatgagcac
      721 atgttaaatt caacaaaaaa ccaagtcgat tttataaaat cagtattgaa agaatcttat
      781 agattaaaag aaatatcaga aaatatttgt gattttgtta caaccccaat caaaaaaaat
      841 agttcaactt ctaagcttta tacaaaacaa aaagctcaat tattattaga aaaatcaaaa
      901 aatattccta taggtatacc aatttttttg atgctaactc ttggattacg ttttggtgaa
      961 gctgtatcac ttatatggtc agatgtagac cttgataaaa aatctcacat gtaaatcaaa
     1021 cattagttta tgtatacaat aaaataatct tcaaaggccc taaaacccct agattcaaaa
     1081 gaagattatt tgttcctgat gaacttataa gtttgtttaa aggggaaaaa ttaaaacaaa
     1141 ataagttaaa attacagggt atattgaaaa atgaatttga tttgatatgc ttaaataaaa
     1201 gattcaaccc gtgagttcaa ccaacttttg ttgttcattt taaaaaacta ttaagagata
     1261 ataatcctag agatataaaa gtacatgaat taatacatgc aaatgcgact ttgatattac
     1321 tttcaggtac taacataaaa gctatttata aaatattagt acatgcagat ataaaaatag
     1381 ctatgaatat atattccata ttctcactta ttagatgaaa tgaataaaga aacatctgaa
     1441 aatataagca aaatactatt caaataatgt tcagttttat gtcaattaaa tgtcactcaa
     1501 agtgcttttt ttccatttgt cagttaaatg tcacttaaag tacctttttc ctatttgtca
     1561 gttaaatgtc agtaatatat aaataagata tatttataag acccttaaaa tcactattat
     1621 ttaataaaat ttataattat atactatttg ctgttgacat tggtattata ccatagttta
     1681 tcatttatat tagaataaaa ttattaatta atagtttcgt aattttataa tagatttaca
     1741 gggagtgata ataaatggat acaaaaatat ctataaacga aaacatgagt ctaggtaaaa
     1801 gattttttaa atacctagca ccatctgtag ttgcaatgtg ggttttctca ctatatacaa
     1861 tggttgatgg aatatttgta agtaaaggag ttggagaatt agctttagct gctgtcaata
     1921 tatcaatgcc ttttattaat tttatatttg cagtttctct attattttca actggtgcat
     1981 ctaccataat tgcaatctat ctggggaaaa aagatattaa atctgctaac gaagtctttt
     2041 catttaactt agtatcaata attatattat caataattat attagctata acttttttta
     2101 atttagatag attagcacta tttttaggag ctacagaatc tacaattggt atggttaaag
     2161 attatttagg aataataata ttttttaacg gattctttat agtgtcttat tctttagaag
     2221 ttataataaa aactgatggc tttccaatat tagctactgt tggtgtaata atatctgctc
     2281 ttacaaacat catacttgat tacttgtttg taattgaatt tggatggggt gtaaaaggtg
     2341 ctggtattgc aactggtttg tctcaagtct tttctactat tttcttctta atacattttt
     2401 taagaaaaaa ctctactttg aatttttcaa aatttagaat tgattttaag acacttagaa
     2461 aaattgtatt tataggtttt cctgattcaa ctactgaatt aagttgtggt atagttgttt
     2521 tactttttaa cttaagtctt actaaatata ttggagaaaa tgctcttatt tattatagtg
     2581 tcataaatta tataaataca ttagtactta tgactatgat gggtataact caaggtatgc
     2641 aaccacttac tagcttttat tatggtgcag gaaatataga taatgtaaaa aaattattaa
     2701 aaatggggat aaaagccaca ataatagcat cagttgctgt atttgcaatt tgtatggctt
     2761 tttcaggacc aatagtctct ttatttatac atccagaaga aacaatgcta ttcaatgaag
     2821 gagttcgtgt atttaaaata ttctctatat ctttcttatt ggtaggaatt aatgtaataa
     2881 tttctggatt ctttgtatca gtagaaaaac catcaatttc tactgttata tctcttggta
     2941 gagggcttgt aatagttgtt ttaagtctaa tttcaatgat actaatattt ggtggacaag
     3001 gaatatggat gactactatt gtttctgagt ttatatgtct tattttatca ttagtttttc
     3061 taaaaaagaa tttttctaca ttagactcta atctaaataa ggttgcttag atgataagag
     3121 tgacaatata tgaaaatatc taaataaaaa atacctatta tacaatcttg caaatattaa
     3181 acctttgcaa aaattaggat tatataatag gtattttatt tatgtaatta ttttatttct
     3241 aaatatccat agccatcttt tattaaagtt ccttttactt catattctac aggtttttta
     3301 aatattggac catctacgac aaatgtatga tactctccat gttctccaca tgggtctgca
     3361 ccagcatttt ttatcttctc cacaagttct ctagttaatt tttttcctaa aaattcctct
     3421 cctaagtgct ttaagtttac ttttgttaca acactacaaa atccactgtc tataaattca
     3481 tatactaaat cctctctact ctcttgccat aatggtaaat ctactttcat accaactgct
     3541 tcacatctat cagtatccca ttttctatga ctttctatat ctatatctcc atatgcacat
     3601 atcgttgctc ccatgttttt agcttttatt aaagccctct caaagctctc ttcatatcct
     3661 tctacgccac actcagcaac taataaaggt aatcctatgt tgctacttac ttgcttaagc
     3721 atattatatt ctaaattatg tgtccatgac tttccatgtt cttcacttat agttgtcaag
     3781 agtgccacag gcttatatcc ttttttcaac attcgattta atgctaatat actatcctta
     3841 ccaccactaa atgacattac aaatttttca tcagccaatt ttaacacctc tttcatctaa
     3901 ctttgtttta ttaacataat tataccaaat ttttgagttg catagcaaat tatattaaat
     3961 tgttaattca ctataaagaa tgtccctaat attaaaagta taacccctat gtatttgtat
     4021 aaatgcattg tttcttgtcc caaaattacg ctatcaataa aaaatccaac taaaacttgg
     4081 gatacaagag ttaatataag tgtatttgat actcctaaat ttggaattgc ctttactgta
     4141 aaatatatta ttagacctcc aaatactcct cctaataaca acttataatt aaaaccattt
     4201 atagatacta gacactttaa gtcacctgta actattatac ttgccaaaaa aaatattgct
     4261 cctacagtta agcttataaa ggtggccact aatgctgttg tactttttcc tagctctcca
     4321 tttataaaag cttcaagagc tgtagaacca cctgctaata atgcaaatat tattgcccat
     4381 aattttgtca tggacaaacc tccttctata taattctatt aatagaagtt tatgatacaa
     4441 cctattaatt aattactaag tatagtttaa tttttataca ctaggcttta tttggatatg
     4501 aatttctgtt ataattgttc tatcgatttt ggaggtgatt ttatgtacac aaattttaat
     4561 atcgatttta ataactttaa taaaaaagaa aatgctatta aatttatgtt aatgggagta
     4621 ttactcatta tattaggatt attatgcctt acatttaaga cattaggtat aaaattaatt
     4681 tcttggactt ttggtattgc acttttattc tttgcatatt taaatttaaa aaatattaat
     4741 gagttaaaaa gatatgctac taaagaagaa attaaaccct ctattaatat ccaatgggtt
     4801 ctaataattg catgtatatt actttttgta tttcctcaaa aaatacaaag catattttca
     4861 ttatttttag gattttattt aatctttaat caactagtag cacttgtaaa tagtaagaat
     4921 aatccttatt ctaaatttac aacttggaat atagttaaga ttctatttgg tatatgcctt
     4981 atattatctc cacttttttt atctagattt atagtatcga taatgtcttt tttcataata
     5041 ttatttggac tagttctatt tttctctgga aatacagcga gaaaatatta attattttct
     5101 cgctgtattt ttatattact taaaatagaa tttgtttaag ttatctattt gtggtaatat
     5161 gttttttgta caagctcagc gtacaatttt attagaaata ggtgattttt tggataaatt
     5221 taaatatgct tttgataata aaagatatca tacttggaat tactatctta gaaatacttt
     5281 tggagaaaaa gtttttaagg tatctataaa tgcaggattt acttgcccaa acattgatgg
     5341 aagtcttggt tatggcggat gtacctattg tagcaaagaa ggctcaggtg attttgctgg
     5401 aaaccctaaa gataatctta tcagtcaatt ttataatata aaagaaatga tgttaaaaaa
     5461 atggcctcat gcaaagtata ttggctactt tcaagcctat acaaatacgt atgctcctct
     5521 tgaagtttta aaagaaaaat atgagactat attagaactt gaagatgtca taggtctttc
     5581 aatatccaca agacctgact gtttgccaga tgatgttgta gaatacttat ctgaactaaa
     5641 taaaagaacc aatttatggg ttgaacttgg acttcaaaca attcatgatt ctacatctaa
     5701 aattataaat agaggtcatg attataaaac atttgttgaa ggtgttgaaa aactaaagtc
     5761 taaaaatata aaggttgtcg tacacattat aaatggtctt cctggtgaag attataatat
     5821 gatgatggaa acagcaaagg cagttggtaa aatgggtgta gacggtataa aaatccatct
     5881 attgcatgtt ataaaagata ctcctatgga aaagatgtta caaaatggta tgttaactct
     5941 tatggaacaa gatgaatata tcaatcttgt ctgtgaccaa ttagaaatac ttcctgaaac
     6001 tatgataatc catagactca ctggtgatgg taagagggat gaactagtag gtcctatatg
     6061 gagcctaaaa aaatgggaaa ttttaaatca aattgatgat actttaaagg ctagaaattc
     6121 ttatcagggc tgtaagtttg tttaatacaa aataataact atagaaatgg ttatataaat
     6181 atagtccttt ctatagttat ttagtattta caaaacaaaa tattaatttg tacatttata
     6241 caatatataa taaaaaatag atagtctaaa ctgtatctac ttatatttta tttgtactgt
     6301 ccactttatt ctataaaatt tataaatagt tattttttaa taccaaatat aatttggtat
     6361 aatttttgtt ggactctaaa atgtatacca ataaatcctt tttaagtata taattctaaa
     6421 tactttcagt tttttcaatc tgctttaact tgttggactt ataaaatatt cttatttcat
     6481 cataagaaag attaagtgct actactgcag atattaacat caacatcact ccaaataact
     6541 tccctaagga aaaactttct cctaatatag tgcaaccaat tattactgaa ccaactaatt
     6601 ctactgatgc cacaacacct gcaactgaca actctacacc tttagatata cctgctgcat
     6661 aaaaaatata tgcaagtgca gctggaacaa tgcctaacat tagcatacaa gataaaacat
     6721 ctaaatcctt agcataattt aagatttccc aaggtcttga agaaggaatc ataaatatag
     6781 ctccaaataa gaaactgtat actaatattg ttgaacttga aaattccttt aaagcatttt
     6841 tactaatagt tggcataagt gcatatgcta ttgctgataa taccccaagt aaaagtccaa
     6901 aagcgtttaa accttgaaaa tccaaacgtc caccagtcac tgccataatt gcaccaataa
     6961 aacaaagaat aagtgaaaat aatttgcttc tagtaatatt ttctttataa catatttttg
     7021 aaaatattgc taaaaacagt ggtgatgtat atagtaaaac tgctgcaatt gatacacccg
     7081 caatgtcaat tgctttaaaa taacataaat taaacattgc ctgacatata atacctatta
     7141 ttactgaata tataattcct tttttgctta tctttaagat ttgtggtgtc cttatagatg
     7201 aatatacgcc taaaactata aatccaaaaa acaatcttgt aaatgctact tgttctgatg
     7261 tcagtccatt tcccattaaa aactttccaa ataatccaag tgtagcccat aataaccctg
     7321 ctattgctat aaatacatac cctttacttt tttctcccat tttaaattcc cttctatttt
     7381 tatttagtca atttacactc ttctttttaa gcaaaaacta tgccatctta aatcaatata
     7441 tatcgactct aaaaccctag tctttccaat aatactaata aattttcaat ttttttatat
     7501 ttatttttca cttactttaa gttgatttag acttatttta attgtaaaat gagttatata
     7561 taacttattt aaagttaaaa tagactgaaa cttatatata aatatcaaat tttaagtata
     7621 ttaatcaatt aaacctattt taatatatca ttaaaaattt aggaggaaaa tataaaaatg
     7681 aatttagatt tggaatttta tcaaaaaata ttagaagctt cccatgatga aatatgtgtt
     7741 tctgatgata aaggaataat aatatattgt aataaagcat ttgaagaaaa ttatggtcta
     7801 aaaaaagaag atattttagg aaaaaatgtt tcttttttag aagactctgg atattcaaca
     7861 aaaagcccca taccaattgt attaaaaaca aagactaaat tttcactgga acaagatact
     7921 caaacaggga aaaagcttat cataactgct acccctatat ttgatgaaaa tggaaactta
     7981 gaatttactg ttgaaaattg tagagatata actgaactta ataatataaa aaataaactt
     8041 gaagacacaa aaaagcaagt aaaaaaatat aaatctgaag tagaaacact atacagaact
     8101 gcacttagaa ttgaggatac tgtaattatg gacggaatag ttatgagacc aatcataaac
     8161 acagtaaatc atgtttctaa aacggatgta agtgtacttt tattgggtga atctggaaca
     8221 ggaaaaagct cacttgctag atatatacac cacaacagca atagatctaa tggcccattt
     8281 ataacaataa attgtgcaac tatatctcca caacttcttg aatctgaact ttttggatat
     8341 acttcaggtg cttttacagg tgcaagtact aaaggtaaag ttgggctcgt agaattagct
     8401 aatggaggaa ctcttttttt agatgaaata ggagatatac cacaaaatct acaggcaaaa
     8461 tttttgcaat taatacagga tagaactttt actccagttg ggagcttaaa aaataaaaag
     8521 gtcgatataa gaattatatc tgctacaaat gttgatttag tttcaaaagt aaaagaaaaa
     8581 aagtttagag aagatttata ctatagatta aatgttatag aaataaaatt gcctcctctt
     8641 agagaaagaa gggataatct agtggaaatt ataaaatatt attttaatag gtactcaagt
     8701 gacttcaatc taaataaaac tatttctaaa gaagctatgg atgctattgc aaattataga
     8761 ttcccaggca atataagaga attacaaaat ataattcaaa aaatcttgct tacttgtaca
     8821 gataatcata taacaataga tgacttacca aacattctta caaaaaatat acatattacc
     8881 aataatggaa ataaaacaca tatatcccaa attaataagg ttattatatc tgactcaaaa
     8941 tctactaatt ataaaaataa aaattttgac actttaatta aagagtatga aaaaaatata
     9001 attttggatg cttatgaaaa atttggtagt tcttataaag tagccaaaca ccttgaaatc
     9061 tcacagtcta aagccaatag gttaattaga aagtatacta atacttaatt ttaaatttga
     9121 taaataaaaa cttaacacta tttacatatt gtaaatttgg ccatttactg ttattatgaa
     9181 tatggttgaa attatttaaa taaatactgt tgacttagtt tcatatattt accattaaac
     9241 ttttatcata aatatcatat cataataata tatttaataa gtctaataaa ctatacgagg
     9301 tgtaaatatg ttaatgaata cccattttat tatggcaaaa tcaatacttg ataatataga
     9361 tgaaaataaa acattcttta taagcgaaaa aaattttata tatggcaata taaagcctga
     9421 tgctttttct aaatataaat taaaaaaaca ttatttagat gagtcattta atatgattgt
     9481 ttctaaaata aactatctat gcagtcttaa tatagatagc ctttctaaat acttttcagt
     9541 aagtagactt agtcaggaac taggagtcat atgtcatttt ttatgtgatt ttttctgtgt
     9601 agctcacagt gaacgttggg agtttaagca tagcttaaat aaacatgtta cttatgaaag
     9661 agaacttgga gcatttgcaa aagatgttga tttatctaaa attaaatgtg gtactataaa
     9721 tagtagtttt gagaagtttt ttactaaact ttatagcgat tacaaaaaga aaactgatta
     9781 tatgaatgat ttaaaatttt cagcttatac ttgtaatagt gtcataaatt atatacttga
     9841 ctctatttta tctaatacaa taaaatcata tcatatagca aattgcggtt aacttaagaa
     9901 tttttaaact tatataaact tataattgaa tataattaaa atgactgctc tatagaatat
     9961 aattttatac ttctctagga cagtcatttt ttatactaac tatttatctc cattataaca
    10021 tctatggcac tttttacact atctactaca taatttgcac tttgctttac atcttccctt
    10081 gccttagaca ttgcaaaact atatttaaat ccttctaaca tgcaaatatc atttggagaa
    10141 tccccaatag tagcaacttc atctggactt acatttaacg tttttattac atgctctata
    10201 cttcctcttt ttgacacact tttaggaact atatttaaag tatatgttcc agaaaaatat
    10261 atttctaaga cttcactaaa ctcacttttt agataaagtt ctattctgga taactcttcc
    10321 aaattttcag aacatacgcc tatatttcct ataagattat caaaactact tcttttttca
    10381 aagtctgggt caactataaa gtcactagaa taatgtctaa aagcagtggt atcactaccc
    10441 acaattacat cacccttata tttaaaataa agttgtgcat cacttgactc aaatctatca
    10501 atgacttttt ttactaaatt atcatctatc gttcttttaa aaattacatt ataatcttta
    10561 tcatatataa atgaaccatt ttcacataca tagtatccat tcatatctaa actatctttg
    10621 ataatattat gtgcttgttt aaaaattcta cctgtagcaa cattaaactg tactcccttt
    10681 ttttctattt cttcaattgc tactatatct tcttttgtta tggttccatt ttcatataga
    10741 gttccatcta aatcacaaaa tatatgtttt atcataaatt aaaagcctcc aaaaacaatt
    10801 ttatatttta ctaatacttt aatcaaaata acttaaagct tttctaattg tattctcaac
    10861 tcattaagca aatctctagt agctcttaat cttatctttc ttctatcccc attaaatata
    10921 tttttcttta ctattgtttt tccatttata tatattgcag tataaaccag tcccacaggc
    10981 ttctctttgg ttcctccacc aggtccagct actccagttg tagatatacc tatattagct
    11041 ttaagtcctt tagcaacgcc ctcagccatt tctatagctg tttgctcact tactgctcca
    11101 aactcttcca aagtttctct ttttactcct aatcttttca ttttagaatc attagaatat
    11161 gttacacaac cttcaagaaa tacagaggat atacctggat agtttataag agatgaagaa
    11221 accaaacctc cagtacaaga ttcagccact gctattgtta gatttttttc tacaagtagc
    11281 ttagaaacag catcttctaa agcagtctcc ccttcagata tggaaatatc tccttcagta
    11341 tatacatatt taccaactct actttttatt ttttcttcta ctggttttat taatttaaaa
    11401 gcttctcttt cattttcagc ctttgcagtt attcttattg taacttctaa ttcttttgca
    11461 tataaagcaa ctgttggatt agtctgctca ttaattatat cgagaatttc taattctaga
    11521 tttgactcac ctattccata taatcttaaa gtcttagata ctagcatttc atttgtgaat
    11581 tgttgtaagt aaggtttgac actctcatta aacatagctt tcatttctct tggaggtcca
    11641 ggcaatacta ttataaattt accatctttt tttaaaattg cccctggagc tgtaccatta
    11701 ttatttttta gtactatagc atcttttgga aagtacactt gtttcatatt attttcggcc
    11761 atttttttcc ctgttttaac aaagaaagat tccaaaacct ctagtgaagg tttatgtagt
    11821 tctaatttct gaccaaagta ttctgcagca gtttcttttg tcatatcatc accagttggc
    11881 ccaagaccac ctgtagtaat tacaaaatca cttctcttta agctttcatc aaaacattct
    11941 aaaagtcttt gtttgttatc tccaacagta ctctgatggt atacttctat tcccaatgat
    12001 gcaagttctt tagctaaaaa ttgagaattt gtatttacta tatctcccaa taatatttct
    12061 gttcctacac ttattatttc agctttcaaa atttatcact ccttgattta tagccattaa
    12121 gactagtctt aagttcataa caataatttt agcaaaaata ataacataaa taaagttaaa
    12181 aaatcattta aacatatctt taaactagat tattattcta aaaccacaca taatataaac
    12241 ttcgtatata gtggtacttt catcctcaac tgttaattca tataattaag tatgtaaata
    12301 aaaagtttac tttaaaataa taaaaattaa aataggagtg tataatatga aaatagcagt
    12361 tataatgggt ggaatatcat cagagagaga agtttcttta aattcaggaa aagagatata
    12421 taataacctt gataaaaata aatatgaagt tgtaaaagta ataatagatg ataaaaaaga
    12481 tatatttaca aagataccag aagatataga ttttgcaata cttgctttac atggaaaatt
    12541 tggtgaagat ggatgtatac aatcaatact tgagactatg gatataccat actctggatg
    12601 tggacctctt tgcagtggga tgtgtatgga taaaaatata actaaaaaaa tgcttagaga
    12661 ttcaaaccta cctactgctc catgggtttt agtaaaatca gttgatgaaa tagactatga
    12721 tgaaatagat aatataggtt atccagtatt tataaaacca aactcaggag gttcaagtgt
    12781 agccacattc tttattcatt ctaaggatga agttgaagaa gcagttagaa aaggtctgga
    12841 agttgatgaa tttgtaatga ttgaaaaata tataccaggt ggagaatata cttcattcat
    12901 attaaatgga gaagtgttcc ctacaatatc tataaaatct gattcaggat tctttgatta
    12961 tgaagctaag tactcagttg aaaaaggtgc aaaggaagaa gttgtttact tagatgaaga
    13021 acttcaaaaa agagtaaacg aaatttctga gacttgttgg aaaattttta attgcaaagc
    13081 atatgtaaga gttgatatga ttataagtga aggtattcca tatgttcttg aactaaatac
    13141 tcttcctgga atgactcaaa ctagtttaat tcctagaagt gctgctgcta gaggtattaa
    13201 gtacagtgaa ctattagata aacttataga atactcttta aattagatga aataatttga
    13261 ggtggtaatt tgatattttc aaatctaaaa ctaaatgata atgaaccaat ttatatacaa
    13321 cttaaaaatt atataagtga tatgatatca aaaggactaa ttccagacaa tagtaagctc
    13381 ccttctacaa gggagcttag tcagctttta caagttagcc gaaattctgt agttttaact
    13441 tatgaagaat taaaatcaga aggattaatc tactctattt caggaaaagg tacatttgtt
    13501 aaatcaaaga ataagtcttc aaatactaca tggtcattaa actgggattg tttagagaat
    13561 acatactcta aaaaagccaa tgaattggac attataaaaa gtgaaattcc ttggagctct
    13621 gacctgattt cctttaaaag tatttctcca gatggagatt tattcgacat agaagaatta
    13681 aaaaaatcct ttttaaatag aatttcacta gaaggacata aattactcaa ctatggatat
    13741 gcacaaggtt ataagcccct tattgactat ttactagaat atatgacaaa taagggtgct
    13801 gatataagta ataaagatat actaataaca aatggattca cagaaggctt tgatattatt
    13861 atgtcatctt ttacccaaga aaaagactac ataatatgtg aaaatcctac tcataatact
    13921 gctataaaaa ttatgaaatc tcataacctc aatatcttag gtgtagatat aaatgaagat
    13981 ggtttggact tcaatatgct agaagacaat ttagttaagt ataaaaataa aataaagttt
    14041 gcatacatta caccctctta tcacaatcct acaggaattg taatgactcc tgaaaatagg
    14101 tacaaattct ataatcttat gaaaaaatac aatatagcaa ttatagaaga tggatttaat
    14161 gaagaattac tctacaatag ttctcatata tttcctatct gttccctaga taatatgaat
    14221 aatggggtcg tatatattgg tagtttttca aaaattttat ttcctggaat gagaattgga
    14281 tggatatttg cagataaaaa agtaatcaat aagctagaaa gtgtaaaaag gtgcagaaac
    14341 atacatgtat cctttttgga ccaaggaatt ttatttgatt atttaagtaa tggaggtttt
    14401 gaaaaataca ttaaaaaaat acgtaaattc tatggggaca aatttaactt tgcatataag
    14461 tgtataaaaa aatatataaa aacagaatat atcttgggtg atggtggttt gcatatattt
    14521 ataaaactaa aaaatataga tactagagtt ttattagaaa aatgttatga aaaaaatgtt
    14581 atatttatgc ctggagattt attttttaca gataactctg gttttgatac tttaagactc
    14641 ggattttcta ggttgtcttt tgaagacatt gaaattggaa taaaaataat tggagaaact
    14701 ataaatgaaa tgttctaggt taactaaata ttgttagcct agtttatttt tatgaggtat
    14761 aatatatata gtttatatga atctaatact gggggataat atgagtaaaa agtcaaaacg
    14821 aagaaaaatt aataaattaa aattaacgat tgtaataact gtattatttc ttgctttatt
    14881 atctatatat gagatactgt tctctaatcc caacaaaaaa ggtaatataa agagtcaaga
    14941 aactatgcaa aataaaaata atacaacaga tgattctaaa aataatcaaa gctctaccaa
    15001 aaagcaggaa gataataata tcaagcctac tttttcatat tcttcaatac cagataatat
    15061 aaaaaataaa atgattggta aatctatgcc tactgatgaa cctataagct ttgatagtct
    15121 atcttattta aaacttacat attatggatt tgatgaaaaa actcatcaag gagaaatgat
    15181 agtaaacagt gaactagctc cagaagtagt ggatattttt aaggaattat acgaaaaaaa
    15241 atatccaatt gaaaaaatta agttaataga tgactatgat gctgtagatg aaaaatctat
    15301 gtctgataat aatacctcat cattttgtta tagaactata gctggtacaa atgtagtttc
    15361 aaatcatggt aaaggacgtg ctatagatat aaacccatta cagaatcctc aagtttctgg
    15421 aaatgatgtt acacctaaag taagtacagt ttatgctgat aggtctagca caaaatttgg
    15481 aatgataaaa aaaggtgatg attgttataa tgcttttgta agcagaggtt ggagttgggg
    15541 tggctattgg aaaaacccag attatcaaca ttttgaaaaa taatagatta gaaataaagg
    15601 tgaattatat gaatttaatg acattggaaa atataagtaa aagctattct gaaaaaaaat
    15661 tactagaaaa tatatctctt ggaataaatg aaggggaaaa aataggactt attggtgtaa
    15721 atggtactgg taaatctacc ttactcaaaa ttattgcagg agttgaagaa agtgagactg
    15781 gtaatataac aaaaactaat ggtattagga tagaatatct acctcaaaat ccaacttaca
    15841 atgaaaattc aactgtactt gaacaagtat ttaatggaac ttctgaagaa ttaaagctac
    15901 ttggtgaata tcaagaaatc ctagaaaaac ttaattcaaa ctttacagag gaattaaata
    15961 aaaaattatt atcagtacac gaaaaaatag atgccttaaa tctttgggat ttagaaagtg
    16021 aagctaagtc agtacttaca aagcttggta taaatgactt taatcaaaaa atagcagaac
    16081 tttctggtgg gcaaagaaag agagtctctc tggcatcagc ccttattaca ccttgtgagt
    16141 ttttgatact agatgagcct acaaaccatc tagacaatga tactatagat tggcttgagg
    16201 aatatcttaa ttccagaaaa ggctcattgc ttatgataac tcatgataga tactttttag
    16261 accgtgttac aaatagaatt attgaactgg acaaaggtag attattcagt tatgatggga
    16321 attattcaat atttttggaa aagaaaatgg aaagactttc gctagaagca agtattgaag
    16381 ataaaagaca aaatttaata agaacagagc ttgcgtgggt aagacgagga gctcaggctc
    16441 gtagcactaa acaaaaagct cgtttacaaa gatttgatga acttataaat agagattctt
    16501 ttaaacctga tgaaaatctt gatatatctg ttgcatcaag tagacttgga aataaaataa
    16561 tagaaataca caatatatct aaatcatttg aagaaaatac tgttatagat aatttagaat
    16621 acactttaac tcgtacagat agaattggta taataggcaa aaatggtatg ggtaaatcta
    16681 cccttataaa tatacttaat ggagaaatag agcctgatag tggatatatt tcaattggag
    16741 aaacggttaa aataggttgt ttttctcaag acgactctca tatgaatatt gatatgaggg
    16801 ctatagacta tgtaaaagaa gctagtgact atatagaaac ttcagatggt actaggatta
    16861 cagcttctca aatgtgtgaa agattccttt tcaatggtac tatgcaatat actttgatag
    16921 gtaaattatc tggtggtgaa agaagaagac tacatcttct taaaatcctt atgacagctc
    16981 ctaatgtgct tcttttagat gaacctacaa atgatttaga tattgaaacg cttaaaatat
    17041 tagaagaata cctagacgaa tttaaaggtg tagtagttac agtatcacat gatagatatt
    17101 tcttagatag aatttgtaat aaaatatttg catatgaagg taatggaaaa attcatatct
    17161 atacaggtaa ttacagtgat tatcttattt atagagagat tcaaggaatt gaatttgaag
    17221 aatctaaaaa ggaatcagtt aaaaaagatg actctactac cctaaaaaaa gaaaaaccta
    17281 aaaatgataa aaagcttaag ttctcatata atgaacaaag ggagtttgaa aatattgact
    17341 ctgatataga aaaactcgaa tctaaaattg caacacttga tgaaagtact gcaaaatttt
    17401 caactgattt tactaaactt caagaaattt tagatgagaa atctaaacta gaaaaagaac
    17461 ttgaatacaa atatgaaaga tgggaatatt taaataatct agctgatgaa atagctaata
    17521 ataagtaata ttaaaataat cttaagttta ataagttttg ctttaaatct gtaatttata
    17581 aatattttaa aggaagtgtc tcaaaatgaa ctttttagtt ttatgagaca ctctttttta
    17641 tgagaaatca aatatatttt catcatttca acaatacaaa agaggcttat ctctattttg
    17701 agacagcctc tttcataatt accttctaat ttatatgctc taatatatct ataataattc
    17761 ttattatatc tatatatcca gtctttcaat ataatgacaa ttaacttcaa tatgatttaa
    17821 aaatactaac aacctttcat aaagtggatg agattcttct ccatatttag cttctaggtt
    17881 cttgcctatt tctctaacag tcctttgacc atcaatttgt aaaaaaacaa aactggaata
    17941 ttcatctagt tctatttttt tgtatttagg tattctagct tttaactttc taaaaaactt
    18001 ttgaatttta tggtcctgtt tttcaagtat agtaacaact ctattttcag ctacttcata
    18061 ttcaagtcca tcagtaattt taaatacaat atctaaaaca tcattactct tgctcattat
    18121 tttttacttt agataaaaca ataggtaatg ctgtaagcac aactaaaact actaataaag
    18181 caattgccat tgaatttgtt gcagcaaatc cacttggtac ctttggagtt acaactccag
    18241 ttacttgtaa tattatacct attaaaccaa tgatagaacc accagcaaca agaccagaag
    18301 ataaacttat accattagaa actttaactt ctttttcttt ttcagtttta gatactaatt
    18361 caacaaataa acgaattaat gctccaacta atattataga agttgttgca attggtaaat
    18421 agaatcctat agctatagtc attattggta aatttaatgc atatagaact attgccataa
    18481 atactccaac aataatcata acccaaggta aactacctga cataatacca gaagttaatg
    18541 ttgacattaa gtttgcttgt ggtaatgcaa attgtacatt atcaccagtt gctctaagtt
    18601 ggtcagaaag taataaaatt actcctacaa caactataac accaactata cttgcaattg
    18661 taaagtaacg ttgcatttcg tttttgctac caccaataat ataagttact ttttgagatt
    18721 gagtataacc tccagctata gcaatagcaa caactataaa tgaaccaaat aaaagtaatg
    18781 atttattagc ttctaaatca gtccatccca ttataacaaa cactaatgtt acaataacta
    18841 gagaagctat agtcatacca gaaactggaa gatttgatgt tccgattgtt cctgttaaac
    18901 gaccagctac tatgacaaat aataaagata ataaaagaga tatgatagct ccaataattg
    18961 ccataacaat gttaccagaa attaagaatg ctgctaaaaa tccaataact actccaccta
    19021 ataaaagtat catttgtata gatgaacctt cttctccttc tccagcactt gatttagctt
    19081 taagtgtttc ttttatagaa gcgattatag ttggtataag ttttattgca ccaataatac
    19141 ctccacaaag catcatacca gcacctatat attttacata actactagat attgctccaa
    19201 catccatttg gttaagaggc attgcaggat tattccatac catagctcca tctttagcca
    19261 tatctgtaaa gtatcctatt aaaggtgcta taccaaagtt tgataaaata cttcctgcaa
    19321 acattgttaa agaaacttca agccctacta taaatccaat tcctaaaagt agaggattta
    19381 cttcaatatc aaatttccat ttgtagaatt tgcttcctac aagactcatt acattgtttg
    19441 ctacatttaa gaatgaacca gttaatacag taataaatcc acttattaca aatccaattc
    19501 ccatgtactt aattgaatct ccaccagcct ctgaagcaac aagtgtttca gatatagcca
    19561 ttgattctgg gtacataagt ttaccatgtt cttcaactat tagatagttg tgaactatag
    19621 cagcaattcc tataccaaat aaaactccac caactccaac agctaagcct tcaaagaatg
    19681 taatttggct tccaattaat ataactgctg gtaatacgaa aataaatcca cttgcaacag
    19741 attctccacc acttgacata ccttggatta agtttttacc aagaataccc tttgaacgag
    19801 caaatgctcc aacaaaagca gaacctatta tagctcctgg aatacctgcg gcaactgtaa
    19861 gaccggcttt cattccagag taagttgtag atgcggcaaa aatggcagct aaaataatac
    19921 cgataatcag tacagctaca tttccaccgg ttctggactt atctgtgata tatggaacgt
    19981 aatcttttcc actaacctca ccataagcac ccttaggtaa ttttttgttc ataaaatttt
    20041 cacccctttt caatttgtat atattataac atatatacat ataaaactta actttttatt
    20101 attttacaaa tagcgagtca aaactactaa aatttaaccc tatattatta atttctactt
    20161 ttagatattt ttatgctaat tttcttttta tttttcaatt ctactaaaaa ctattaagat
    20221 ataaaataaa aaaatttttt aatgtaaaat taattttgta aaaaaaatgc tttaaaacac
    20281 ggaaaagtat aaaaaataca ataatcattc ttataaataa attttcacca tagtaaatat
    20341 atacagaaaa ttcttgtttt tatgcaaatt gattctttta taaaaataag tgtcataaag
    20401 aaatgtctga aatcacttta tgacacctat cataataaaa aattattctg gtaatgctct
    20461 tttatttact tttccgattg gtgtaactgg tatcttatct atcctcatta ttattgttgg
    20521 aatcatatat ggaggtagat gctcatttaa atattctcta atagttcttt catttatctt
    20581 accactatct tcctcatcaa ttacataata tgcacatata tacatatctc catcatcatt
    20641 tgttctcgat atacaaacaa cacttttaat ttctgtaata ttatttatta tattttcaat
    20701 ctcatatagc tctatcctaa actcatcaat ttttacctga ttgtccatcc ttccaatata
    20761 atctaaattt ccatcatcta accatcttac taaatcacca gttctataca ttaacttatt
    20821 atgttcacaa gttttgtaag gattctctac aaatacttgc tctgttagcc cttttttatt
    20881 taaatatcct cttgatattt gaatgcctga tagacatagc tctcctggtg ctccaattgg
    20941 acatagtttg ttctttttat ctaatacata tgcataagta ttaaatatag gttttcctat
    21001 tggtattttt ccatattctc tgtccacatg aaaagaagtc gatacaacag taaattcggt
    21061 tggtccatac tcattatata gttcataatt acgctttcta tatcctttta atctttctcc
    21121 tccggtctgt acaactctaa gtgaattatt attgcaattt tgtataaata accttgcaaa
    21181 tgctgttggc aatgctagta tagttatgtc attttcctca cagtattcat ttactgtata
    21241 ttcatcaaat ttagcttctt caggcataat atctattgat gcacctacaa gcaaataagg
    21301 gaatagttgt ttcattacag catcaaaact gaaacttaag tatataccac atatatcatt
    21361 ttctgtagcg cttatagatt ttacgctata ataacacata tttactaaac tcttatgttc
    21421 tatagctatg gtctttggcc taccagttga ccctgaagta gatatcgtat atgcacaatt
    21481 tgatgatgtt attttttcag ttaattcata tccaagctta aacatttctt catcatttat
    21541 atcgagtact atggtattct catttacaac cttacttttg agttcatctg tagttatcac
    21601 tacttttgca ttactatctt caagaaggta attcaatctt tcttctggat tacttgtgtc
    21661 tattggaaaa aatgctcccc ctgatttcat aatccctatt gctgtaataa ttatgttaat
    21721 atctcttggt aacattacag ctactatgtc ttcactttcc actcctatat gatttaaata
    21781 acctgcaagt ttatcagtta cttcatccaa ttctttatat gttaactttc tattttcatc
    21841 cctagcagct atattactag gtgttacctt aacttgctcc ctaaataaat caacataact
    21901 tttatcatat ggtatttcat attgattatt attaaagtct tccaataata ctttttcttc
    21961 ttccttacat acaaattcta aatcttctat taaaatatca ttatcttcta ttatttgctc
    22021 tattatataa tcaaattgat ttaaaattct tctaatagtt tctcttttat atatagatgg
    22081 tttatacttt atttttattt taagtgccct cttagtatat actattacag ataaatcata
    22141 tccttttttt tctatgtcat aatcatatga taaatcaaaa cttttagcta taaatattgt
    22201 gtttataagc ttagtattta gatgattttt attctctata tctgataaca aatagtatcc
    22261 atactctaaa gacctgctcc actgcctttt tagcttcctt acaacatcta taaatttttc
    22321 actttgtcta actcttactc ttattggaat tatattcatt gttttaccaa aaactacatc
    22381 atcttcatat atatactttt gaagtataag gccatatata gtttctatga tagagtctat
    22441 gctaatattg ttcactttag aatattgaat taacctttca tgtttctcaa tattcatctt
    22501 aaaaacctca tctactactt catcagaaca atctttataa aaaaaatcat ttggaatttt
    22561 tgctatattc gtataatcat ctaacaaatc catccaataa ttcatagctc gttctaaatt
    22621 aacttcatac atatcaaaat tcccccttac tactaagtct atagaaaaaa ttcttttgga
    22681 attttatttt cacaatatat aaatatatta ataatacata tgcaagctct aaaaacatga
    22741 gcttgcataa aattacactt attatgacta ctaaattcgt aatatttaca atgtttaaaa
    22801 tatattataa cacatatatg attttatttt tctacattta tataatatat aaattacaaa
    22861 tagttattta actaatatat aacaatacct tttggaatat gatatattat attaattaaa
    22921 tttttataag ataagttata cttataggag ggaaccatat aaatgaatat ttatgctcat
    22981 agggggttta gtggaaagta tccagaaaat actattctag cttttaaaaa atgtttggat
    23041 atggatatat atggaataga acttgatgtc cacagaacta aggatggaaa aattgtagtt
    23101 attcatgatg aaaaggttga tagaactttt aatggacatg gttttgtaaa agactttact
    23161 ttaagaaaat taaaaactct aaactcatct tttgaaggat atcaaagcaa taaagaatgt
    23221 aaaattccaa ctttagaaga agtattaatt ctaatttcac ctacagacct tattttaaat
    23281 atagaactaa aaactgacaa aataaactat cccaatatag aaaaagacgt tttagagctt
    23341 attttaaagt ataatatgaa aaatagagtt cttatatcta gtttcaacag caatagttta
    23401 aaaaactttc ataaattaga ccctagtata aaaacaggat tattatgtta tttacctata
    23461 aacaatgtag tcaattttgc taaatttctg ggtaatagtt atcttcatcc acctctagtt
    23521 ttagtaaatg aatctctaat tgaactttgt cacaaaaatc tacttggtgt caatgtatat
    23581 actgtaaatg aagagggtga tatactacac tgtctaaaac tcaatgtaga tggtattttt
    23641 actaactatc cagatattgc ttcaaatctt ttacactcaa aacaatacag ctaattatac
    23701 aatagtttgt actccttgac ttttatataa ttaatatgta caattttatt aaatttatct
    23761 tggaggtata actatggata acttattaaa tgaacttgaa gctttaaaga gtaatttaga
    23821 taatctacca atagaaaaaa tagaaaatta tgatttgagt aaaactgctt tatttataat
    23881 tgatgttaat aatggctttg caagacaagg tgcattatac tctcctagag tagagtcttt
    23941 aataaagcca attgaaatgt ttacaaaaaa aatatcaaac aaattaaata gagtaatagc
    24001 atttactgat tctcatactc ctaaatcaat agaacttttg agttatcctg ttcactgttt
    24061 ggaaaatgat gtagaaagtg aattggttga tgaacttaag tcgatagaaa acctacaaat
    24121 tcttcctaaa aattctacta atggattttt tgcattagaa aatttggatt ttgataatat
    24181 agataatata attatagttg gcgattgcac agatatatgt atatatcaat ttgcaataac
    24241 tctaaaatca tattttaatc aacataatat tgaaaaaaat atagttgtac ctatgaattt
    24301 agtagatact tatgatattc ctaacgttca ccctgctgag attttaaact tagtattttt
    24361 caacagtatg attcaaaatg gagttaatgt attaaaagag attcgttaag cttctaatac
    24421 tttacatccc atataataca attatcagat atttattttt aataaaattt ctaatagaaa
    24481 aacacagttt tagtgagaag attacaattt aaaacactat ctattattac taatcttcac
    24541 aatataaaaa atcgcagttt agatattcct tatacaaatt tataaggaat aataaattgc
    24601 gatttttatt tttaagtagt acaattaatt tatactactt cagtatttaa attcattttt
    24661 taataatcat acttattcgt agtttcgcac attactacct ttattttttt attaaacata
    24721 ttcttatatt ctaataaaaa ctcatttagt tctgaatcca taagatttat ttttctatca
    24781 ctacaaagca ttatcttttc ttggtcgatt attacattaa tatcatttaa gtcatttttt
    24841 ataaatgttg ttatacaact ctttggttgg attttttctc catatttctc ataaaatcct
    24901 gcactcttct taaatgactc taaatcttct gtagatactt tgctggaagt attattactc
    24961 ataaaacctg ctgtagaagg gtcgattcca aagtttctaa gttgtttttc tacttcttca
    25021 gtgtccatac catatctctc cataaattgc ttttgtattt tcataaattt ttcttgagat
    25081 atgttgttat ctctcatata atcgaatatt tttcttgaaa actcagccat agacatcttt
    25141 ccatccataa cagaaaaata taagttatat atgtattgct caaatttatc tacatcagaa
    25201 tctttaactt tgttctttag ttcgttaaag tctattattc tatcatcaga catttttcat
    25261 cctcctagct aaatttttac ttgtataaga ttataccata tttctattat atttatatac
    25321 acactatttt tttaatttaa cgattttttc tgtagcatct aattcgcaca ttctgcccaa
    25381 aggaatagtt atcattggga tacaatgtcc tgactgaaga ttatatatag aaggtttatt
    25441 gaccttattt gcaaattcta ttagtaattc catcaaatca ttttcttcaa tacaatcctt
    25501 aaaatctcca aaaattatac cattacattc ctcaagtttt cctgaagaat atagttgtgt
    25561 taacattcta tccagtttat attgaggttc tccaatttcc tcaataaaca aaattttatc
    25621 ttttgcatct atttcatatt ttgttcccat tgtggcaatt attaaggata aatttcctcc
    25681 cattattatt ccctctgctt taccttcaca tacagtataa atcttttctt cttttggatt
    25741 ttctaaatat aattcatctt taaattctaa agcatttacc aatgatttat aggtaaattt
    25801 accccattta cctacatttg ctgccattat tccatgatat ggtaaaagac cacaattttt
    25861 atagaaagct aaatttaaac ctgttatatc agaaaaacct ataaatggtt ttggattttg
    25921 ctttattata tcataattta ttttatccaa tattcttgtt gttccataac ctcctcttaa
    25981 gcacataatt atatctacat ctttatctaa aaacatatct tctatatccc ttgctctaat
    26041 atcatcatta ccagctaaat aacctttata atttaaacta caactttcag aaaacttaac
    26101 ttcgtaacca taactttcta aattaaactt tatttcctcc aaacttgtat ttcttaatgg
    26161 cccagatggc gcaattattc ctaacattta aacacctctt cttataaaat gatatattct
    26221 tctccatact aaatatctct aatataatta taagatattt tatttgtact tgatacataa
    26281 taatgattta cataaaataa tataattaat gaagaaaaat aaatttttaa tatagttagg
    26341 atgtgtttta tgcttaatat aaaaactctt tgtcatgaga taaatgattg ggttataaat
    26401 ataagaagag atttacataa gactccagaa cttggattag aagaatttca aactaagaaa
    26461 aaaattatta aatacttaaa tgaaataggt ataaattata ttgaatataa gaatcataca
    26521 gggataactg catacattaa cgtgagtcca aactttgaaa cagttgctat aagagctgat
    26581 atagatgcct tacctataac agaagaactt aattattctt ataaatctat taatattggc
    26641 aaaatgcatg catgtggtca tgatgcacac actgctattt tactgggtac ttgtaatata
    26701 ctatttaaat taaaggatta cttaaatgta aatgtaaaat tcttttttca acctgctgag
    26761 gaaactattg gtggggctca acttatgata gaagatggat gtcttgaaaa accaaatgta
    26821 aaatatatat ttggactcca tgtaaatccc aatatcaaca aaaatctaat tgaattaaaa
    26881 tacaacactc taaatgcttc caccaataca cttcaattaa ctgtacatgg ttcaaaatgt
    26941 catggagctt atccacatca aggtattgat gctattgtta tatctgctca tattattaca
    27001 gctctacaga caatcgttag tcgaaacaca aatccaactg attctgtggt tatttctcta
    27061 ggaaagattg aaggtggaat caaagaaaat atagtttgtg acaaagtggt tataaggggt
    27121 actttgagaa ccttgactcc tgaaactaga gagttttcaa aaaaacgaat tagagaaatt
    27181 tgcgatttta cttgtaaaac atttggagga agtatttctg ttgaaattga ggaaggttat
    27241 ccagctctta tcaattcaaa ccatctagta gattacgtca aacaaaatgc tgtagaattg
    27301 tttggtgaag aaaatattat ccttaaagac tcgcccactc ttggtgctga agacttttcg
    27361 tattttctaa gacactgtga aggagctttt taccaccttg gttgtgcaaa tcgtgaaaaa
    27421 aacattactt cccctttgca tacctctact tttgatattg acgaagattg ccttattact
    27481 ggtgtcatgc tccatgtaaa aaatgtatta tcattctaac tattaatatt tttatttatt
    27541 attttatatt gaccctcaca tgatgtcatg ttatacccta aaattacaaa tgataaatta
    27601 aatagttgga ggtaatatta tgaaagaaat attaataaat cctataggta aaatatgtat
    27661 tcaaggcgaa gaggtcttta ttaaattaga caaaaagtat gtacctgcat taaatgaact
    27721 cgacgatttc agtcatttaa atgtattttg gtgggctgat gggtttgata atcctgaact
    27781 aagaagtatt ttagaaaccc caaaacctta taaaagtgga ccagacgtta taggaatatt
    27841 tgcaacaagg tcacctataa gacccaatcc aatagcattg actgctgtac aaattatcaa
    27901 tatcgaccat gaaaatggca taataaaaat accatatatt gatgctaatg ataatagtcc
    27961 tgttattgac ttaaagccat atactccaag cgttgatagg gttgaaaatc cgtccgttcc
    28021 taaatggtgt agtcactggc ctaagagtgt agaaaaatca ggagaattta attgggaaga
    28081 tgaaattgaa ttttaaatta cttttttctt gatttcatta acttgttttc cacatttatt
    28141 ttatttacac ttaccaagat tttatgtcac atatacatat aatattaggc tgtattatat
    28201 aatacaacct aatattatat aataaatttc tatttttccc ttaaatcatt cacattcttt
    28261 ctaagctaca taagattttt ctattatttc tttttgagtt taatttagca ttatgttgag
    28321 gaaaaaacat ttcatgcatt ttaataaatt aaatttttct tttattctgc gattttataa
    28381 taatcaattt aacttaaaaa taatacctaa ctattttaac tatgttaaac tagtaaatgt
    28441 aaccacttat atgttacaat tttatataaa catcaaatat aaaaaactat ataaataaat
    28501 gacacatagt gttatatttt tttataccaa tttagttatt tttcagttac agatttaata
    28561 atagttaata gtaagacata atatttttat gccctttatt gattatgtat tttctgttat
    28621 ctgttattat catcaataat aaacataagg gggtatatat tatgaaattg tatttaagtg
    28681 ctgatataga aggtacttgt ggtattgtaa attgggatga aacaaaactt gaatgtgaat
    28741 tttcgcaaca ctatagaacg caaatgagta aagagataac agcagcatgt gatggagcta
    28801 ctcaatctgg tgtacatgaa atacttgtta aagatgcaca tgacagtggt agaaatatta
    28861 atccaaatat tttacctgaa aacgtcaaaa tacttagagg atggaccaaa gacccactag
    28921 ttatgatggc aggaattgat gaaagctttg atgcatgtat attcaccggc tatcactctg
    28981 gagctacttg taatggtaat ccactttctc atactatgga tattgattat gactatttta
    29041 aaataaatga tgaaatagca tctgaattta ctataaatgc ttatattgct gcatattata
    29101 atgttcctgt agcattttta agtggagatg aaatgctttg tgagagtgca aaaaaactaa
    29161 atccaaatat agtcactgtt cctgtgtcaa aaggaattgg aaatggttca atttcaatcc
    29221 atccaaacct tgcactaaaa aaaattgaaa aaggtgtcaa aaaagcttta tctggagatt
    29281 tatctaggca cttaataaaa ttgccagata aatttaagat agaaataaaa tttagagaac
    29341 attataaagc ttttaaggcc tctttttatc caaatatgaa aaaaatagat tctcaaacag
    29401 tactatttga aacagaggac tattatgaat ttttaagaat gttattattt atataaattt
    29461 catatcataa attaaggagt tgattaagat aagtaataaa agaaggattc ctttaggcga
    29521 atttatttct gtatttttat tttttgctgt tttttttggt ataacttttt gtattttcac
    29581 ggttatagga attggcttct tatcattctt aggatttgaa tataaatctc ttggagctgt
    29641 attaattttc tttttaatat atttttgtat aaccactcca attgattttc tatgcactac
    29701 tattttagat atattcagat atgtaaacaa attaccatac tcaatatata aactttgcga
    29761 atttataatt gattttatac taacttttct agctatgaac ataattgata cctttatgga
    29821 ttcagtaacg attcctttaa gtacagaaat cttattcgct ttactttctt atcttttatc
    29881 agaatgtatg gatttttttg atagggataa gaaaaaacct taataaaaaa gatagattcc
    29941 ttaatagaac acatattttc gtatttctat tatttaatct atctttattt tatttaataa
    30001 atttttatta attaaaatat agtttcttct atctccttag tcatttgctt agcactatca
    30061 aaaaattctt ctatatacac tacttcatca ctgaccctag aatattctgc tgcaaatgcc
    30121 attacatgac tttgtatagc ttcttttgct gctactctac ccttttctag ttctttattt
    30181 gaaactaatt taataaattc agctataaga tttctatcat attcctctac catattctgt
    30241 tgatttgatg gattcataac tatttcttcg ttttttccaa attctttaat tcttatctca
    30301 tttttattta aatccccacc aacttcacca tggctaaaca ttaactttat agttcttcca
    30361 ttttctttag taaatgcaca taaattaaaa gtagccgtca ctccattttc aaactgtagt
    30421 atatttacca tattgtctac aacattatta tcacatctgt aaacacatct tccatatgga
    30481 cttgtcttaa gtatattcaa tagattctct tcagttggat ttatgtgaac agctctattt
    30541 atacttctat ctttttctaa ataaattctc tttgctgaat atggacattt tttttcaact
    30601 aaacactgaa gacaattttg tgccatctct ccactagcat tttggttatt aagatgcttt
    30661 aagcttccaa atgcagatat ttttttgcat ctacttccta ctaaatataa caaaatatcc
    30721 atgtcatgac aactctttgc taaaattaaa gggctggttt cattgctatt tctccaattc
    30781 cctctagtaa agctatgtgc aaaatgccaa tatcctatat tttcattata ttgtatacta
    30841 actagctctc ctaatttttt gctttctaca atttctttta atttattata aaatggagaa
    30901 tatctcagta catggcaaat cataaaaatc ttatctttat acttatcaca caagtcatct
    30961 atatgtacca gaccatctaa actattagac attggctttt ctaatagtac atgataacct
    31021 ttttcaagag ctagttttgc tacatcataa tgtctatcat catttgtagc tattattact
    31081 gcatctgcca tcttgtcatg tttaaaaaag tcttctaaag tttcaaatac atttttacta
    31141 tctaggttat atttttgtgt aaatagttct cgtcttcctt ttttaggttc tgctacagca
    31201 actatttcac atacatcaga attttcataa atatatggag catatgcata cgttcctcta
    31261 ttacctgctc caatcacagc aactttcact ttttccatac tttaatttat cccctttata
    31321 ttatttatac tactctatta tagtctattt ttacagacat ttggatattt ttaataaaag
    31381 aaacagcagt tataattttt caattttaac tgctgttata agttaatata ccaaacattt
    31441 ttaattaaat tttctttaat tttaatacaa agacttaaat attaaataca aattataaaa
    31501 acacttttat ctagtttact tcttcttttc tttgtctaat ttatctaact tcttattgta
    31561 taaaaacata taaaatgctg ccgaaaatac tattaaatat ccaacaacac ttaacatatc
    31621 tggatagaca ttgaataaga atatacttaa aattgctgaa aagattatat tactatagtc
    31681 aaatatagag atttccttag caggtgcata tttatatgct agagttattc caaattgacc
    31741 tagacttgca aatactccac ctagtaatag atatataagt tgcataaggg tcattggttc
    31801 atatactgca aaagcaattg gccctacagt aactaatgaa aaaactgaaa agaaaaatac
    31861 aattgtatag taatcttctc tatctccaag aactcttaaa caagtatatg ccattgctgc
    31921 aaatacagct cctgcaattc ctccaagata tggaattact tctacactaa atgttggttt
    31981 tattatgaat aaagctccta taaatgcaat tataatagct cctatctgct ttacatttat
    32041 tttttctttt agagcaattg cacaaaatat tactacaagg aagggactca ttttatttag
    32101 catattagca tctgaaagca tcaacttgtc aattgcatag tagttaaata taactcctag
    32161 agttccaaat attgacctat ataaaagtac ttttaaattt tcttttttac cagttagact
    32221 tcctttatgt tttatgataa gccaaaaagc tattatagct gataccagat ttctaaagaa
    32281 cactttttga aaacttggta aatctccagc tagctttacg aatgcagaca tcattgcaaa
    32341 gccaagcgct gatgctatta taaacattat accttttatt cgatttgatt tgattgtgct
    32401 actcatacgt acctcttttc tatataaatg tataaagcca tattaattaa aaacttagct
    32461 tatacattaa ataataatta tctaaatatt ccaatttata ctataattaa aagtgtaaac
    32521 tatgtcaagt aactaataaa tcttttcaat taataacaat aataattata gctaaaaagt
    32581 tatatgtttt tatggattat tatcagaata tataatataa ttttatatag tatagacttt
    32641 ttttaattta ttatttagat ttttaataga ttttttaact atggaggtat ttaaaatatg
    32701 gaaataaaga gatatgaagg aactggaaga atgagtagag ctgtagttca taacaataca
    32761 gtttatttat gtggacaaac tcatgctgaa ggaggagtaa ttgaacaaac aactgaagtt
    32821 ttagctaaaa tagaagattt attaaacaaa tatggttcag ataagcaaca tttgctatct
    32881 gttactattt atttaagaga tatgaaagac tttgaagcta tgaactctgt ttgggatgct
    32941 tgggttgaaa aaggatttga acctgctaga gcttgtgttg aagctagact tgctagagag
    33001 catttgttag ttgaaatgag cgttgttgca gctacaaaat aatcaattta gcttatagga
    33061 ggctatctca aaacagagag ataagcctct ttttcattgt tgaaatgatg aaaatatatt
    33121 tgatttcgta taaaagaaag tgtctcacga actaaaaaat tcattttgag acacctcctc
    33181 actatttaat ctatataaat ttacttattc tctattggca atatcaattt agatggatat
    33241 ttacctccat ggtaaatcgt attctttgct tctatatatt caatactatt atatccctct
    33301 gtcgtgttgc tattttggaa aataaagttt ttagcactag acgttatatc tagtctaatt
    33361 ttatgaccaa ctttaaacgt gtttgatatt tttgaagtta taatcgtaaa cttataaatc
    33421 tctccttctt ccataaactc tgacttataa aaactatttc taaatctagc actaagtata
    33481 ccatcagcta atttaattga atttccatct aaatccacgt ccataatttt tataacccag
    33541 tcagtatctt tggcagaact tgatgcaaaa aactctaact ttatatcacc tgttacagta
    33601 aattcttcac taaaagcatc tgatgtataa cacaacatat cacttctttt ttctaaatct
    33661 ttgtagttat ttggaactcc aacttcattc tctgacatat caattagttg tactgatggg
    33721 tcttttggat tatatatata actatcatac ttttcttcta aatcattatc aaatactaat
    33781 ctaccatttc ctaaagatgt gttagcattt ccatcactta ttagatacat acttttatct
    33841 atcttattta ttattggcca attttcttct gtcttccact tattagaacc tacagagtaa
    33901 tactctactg gagcagtcgt atctatgtta ttttctatac cttttaagta tttatcaaac
    33961 cataatagat aattataatc caaatcatat cttaatgaac tatttcctaa agaaatacca
    34021 tttatatctc ttaaagtatt tgaattatgc atccatggac ctagaatagc ctttctcttt
    34081 cctttttcat agtcctttat aacatctaag gcctctgtag ttcccatact attatcatca
    34141 taccacccag atacaaccaa tgcaggtaca tttattttat ctttttgtaa atgccagtcc
    34201 atcaaatccc aatactcatc tttttctact ctctttaacc attcttccag aaattcaatt
    34261 ctatatccaa gagcttcaac aggtatattt tctattggtc gtatgtttaa aacatcatcc
    34321 caatcatctc ttaccatttt gcttctatca actttatttc ttgataccat aaatgcccat
    34381 gcaagcatac cagatacaaa agctcctcct tttcttggta tatcaataaa agggcttcct
    34441 gatgttacta tactaactaa agctttaaga tgcttattgc ctgaagatgc agctgcccat
    34501 tggacataac caagatatga tgctccaagc attccaacta ttccacttga ccattcctgt
    34561 gatactatcc aatttatggt actatctcca tcttccctct catgaatcat aggttcccac
    34621 ttaccttctg attcatttct tcccctaaca tcttgtatta caacagcata tcctctttgt
    34681 acatatttat aatatatttc tttatcattt tcttttccat atggagttct cataagaatt
    34741 gtcggtgctt ttttggcaga atctacaaaa tcagggagat atacatctgt agaaagtttt
    34801 ataccatctt tcatatcaat catataattt ccaccaaatc ttatagaata tatctcttca
    34861 tttttatgag ttttttccca ttcttttaat acagtatact cttcatatcc atccataatt
    34921 aatatagtac aagtttctct agataaacag ataaaaccta ctattttatt atctacaata
    34981 attatatcta gtgggaactt tttgtttctt tgaacccata tatattcatt aagtttagaa
    35041 tgcgtttctc ctaagttatt tataactgtg tctttatctg tgtttactaa gcttttagta
    35101 tatacatcaa aattattaaa taaagacttt aaatctattt ttgtaagatt taaataatat
    35161 gtattttctt ctttgcttat tggttttaaa ctttctattt tatttgtaaa aggattcaac
    35221 ttttcaatta ataaatctcc atcaaagatt acatttccac tgtatagtcc agatatgtat
    35281 aatttaaatt ttatcaatta aactcccccc tataatccta gagacatctt tattgcatat
    35341 gccactgata tacctgcata atttcctaat actccaccaa ttactcccat tacgactgct
    35401 acacttacaa gcgaattcca ctttgcagaa gcagctacta aagctgaagt aggaccatca
    35461 gcaattgctc ctactataga aagtattaca tattgatact ttatctttaa aagtctagtt
    35521 atgcctaaat ggaaaacaaa tgaagcaaaa attatactaa aacagtaaag tgttatagta
    35581 aaagttgaac ctaaaaactc ttttatatct actgaaaaac ctattgtaca taaaaagaat
    35641 aatgcaacaa ataatcctaa atctaaattt ccctttagtt tctttactgg ctttaattga
    35701 gcaattataa ttgaaattgt tgtaactaaa agtattcttg ctgcactact aaaacttgaa
    35761 ttgaaatatc cagcaagtat tgttgaaact tctgtaacaa caaaacctat agccaacatc
    35821 caagctatat ctttaatact ccattctttt gactccataa attcttcatt ttgacaatct
    35881 tctaattctg attcttctac atgatatggc caaagttttt taaacttctt tgaatttttt
    35941 aatattgctg gtagagcaaa cataaatatc aatgttggta ctccaattac atagtctgct
    36001 gcatttgctg ctgcaagagt ttgtctactt acattaagac ctgttccaat agctgtaaga
    36061 ttagcacttc caccagtata tgtacctaca aacattccag caaccttcca accttctgat
    36121 attttttctg caaatactaa tccaaataaa aatgccatga tacttacagt taatacagct
    36181 acaaaaattg caattaaagg ttctcttgat aattttgtca tttcttttaa gtcaacactc
    36241 atcaacatta tagtcataga aattggaata gcatatgttg aaatagttcc atataactca
    36301 gtacttactg gaactacttt taagtttgaa agtattattc ccattatgat tattgtaagt
    36361 gctggtccta agcttttaat ggctttgtat ctttgtaagt aaaaacccaa tgcaatcatt
    36421 gatgtcatta cagcaagtat actacctgga tttgaaaaaa gtgtattcat atttaacctc
    36481 caaatttatc ataagtttac ttctattcct aaacctggtt tattgacaag attcataata
    36541 tctccatcca ttacaaatcc tccagatata ccttctaatt cttcacaaaa cataaaacta
    36601 tcaaggtcag cttctgttat gttcttttta gatgctatta aatttgctgc tgctgttata
    36661 ccaattctcg tttccagcat acatcctaac atacaattta ctccacttgc ctcagctatg
    36721 ttgttgattt ttatagcagg atatattcca cttgatttca tcagcttaat attaaatgta
    36781 tcaactgcat tcttttttat agccttaatt gcatctattg gtgaatgtaa tgattcatct
    36841 atcataattt ttgtgttact tttatttctt atgtaagcag taccatctaa atcccaatgt
    36901 ggaagtgctt gttcaattgc atcaacatta aattcttcta actttttgat agtatttata
    36961 ctgctattta cgttccatcc ttgatttgca tcaattctaa ttcttatact ctctccaacg
    37021 gcttctctaa ttaactttac agcttcaata tcgtcttcag gatttatacc tgctttaagc
    37081 ttcaatatcc taaaaccttc ttttactctt tctaaagctt ctactgccat tttttctggc
    37141 ttatctatac ttatagtaat atccgtttgg actttactat caaatcctcc aagaacttta
    37201 taaagaggtg cattcataat ttttccttta atatcatata aagctatgtc aatagctgct
    37261 tttgcagaag tattacctat aataattcca tccatgatgg tatgtatggt ttcaatatct
    37321 agtgggtctt tgcctattaa ctctttttta aacataagca atactgaaag aacattatcc
    37381 aaaacttcac ctgtaactgc tgcaagaggt gctgcttcgc caaatccaca atacccttca
    37441 tcagtttcaa tttttaaaat tatactttct ccatactcaa ttactccaaa tgaaactact
    37501 acaggttttt ttaatttaat tctaagcttt tcaaatttga tatctgttat cttcatatta
    37561 ccctccttat tttttgaagt tataattcaa tttttaaaat tttatacttt aaattatatt
    37621 attacttcaa tatatatgtc aagataattt actgaaaatt tactcttttc caaaatataa
    37681 tgtgataatc ttaattcaat taatactctt ctattaaatt tttttattat tattttcttt
    37741 gtattaattt aacaataatt cattttcata gacttttatt tggatttaat taaattttaa
    37801 ttgtcaaaat ctactatgta ttcttattgc cactacttct atgttgtgct ataattactt
    37861 tgttttaagc gaatatttta tattaatttt attatttgga ggttcttatg ctaggtgaaa
    37921 agatgagaaa tataagaaaa agcaagaaaa aaacattaag tgatgtttcc aaattgacag
    37981 atttatctat aagttatatc tctcaaatag aaagagatgc tattgaacca tccttgtctt
    38041 cattgagaaa aatcgctgaa gttttagaca ctcctttata tatgtttatg gatgacaata
    38101 atactgatga tttagtcatt agaaaagaag atagagttat gatgaaattt ccaaagagtg
    38161 aaatgtttta cgagatagta tctccaatgc ctacaactga gtttacacct tcaattttat
    38221 ttgtagagtt tgaacttaaa ccagaaagtg aggatgccaa agattatata tatcatgcat
    38281 cagaagaaat tatggtggta acgagtggtg tggttgatat ttgtatgggt gaaaaggtag
    38341 ttagattaaa tccaggtgac tcaacattta taaaagctaa tgtaccacat aaaatcatca
    38401 atccaagtaa agatacaata gctcgtggat atggagttat atcacctcca atttggccaa
    38461 taaaatctaa ataaactcaa tatgacacac ctactttttg tagataatat aatagattta
    38521 aatattgctt ttattttaaa tttaaaatat ttactcaaac taaaaaaata gctatttgac
    38581 taatctaaac catcttaatt atggtaaata gtaaatagct atttgtaagt tatattataa
    38641 attataataa aaattgtatt tgttaaaatt aaactgctat atcatttaat acttttgcct
    38701 ttacaactct tatatttttc atactcttgt agatatcttg aatcttatct tcttgctctc
    38761 tcaatagtct atgtgcttca tatatatcta caagttcaaa ttttactaca tcatttggct
    38821 ttgcttgtgc taacttatac aaatctacac ttataacgtt ccctatctta gtatagccac
    38881 cactagtctg tctatctgat aacattataa tcggttttcc atgaccaggt acttgtatag
    38941 ctccataaga aataccatca gatataatat ctgctccatt aaggtgcttt atactctctc
    39001 catctagtct acaacccatt ctatctattt cattcgtaac tttgtattta tttgataaaa
    39061 atttctctac ttcaccgtta gaaaaagcat caaattgagg accttttaca attcttagta
    39121 cgatttctga actataagtt ggaatatatt ttgaacttaa ttttttattt attgtaaaat
    39181 ctttttcctg aataaaagta tttatataat ctcctttttt aagtgctcta ccttcaaatc
    39241 caccaatttt agctcttgta taagttgact tacttcccat tgcaagtgga acatctattc
    39301 caccagctat tgacacatag gctctagcac ctgatttcac acctctaaat gataatacat
    39361 cacctggatt tatttgatat gacctccagt tttgaatttc ttttccattt attttagccc
    39421 ctaaatctcc cccagttact gctatttgcg tatattcatc aaaggtaatt gtaggaccta
    39481 acattaaaac ttctaaagaa gcctcatctt cagaatttcc tactaatata tttcctactc
    39541 tatgtgcata ctcatccatt gctccacatc cagatacacc atattgacca tagccaactc
    39601 tacctctgtc ttgtattaat gtttggaaac ctcctaattc aactttgaat cccatatata
    39661 ccactccctg tactataacg atatttaaat acttaagtta tttttttcga tttctataaa
    39721 ttcatctaat gttattggaa caaattttat aaaatctcca gctctaagca aaatctgttc
    39781 ttctctattt tcatcatata attttaaagg tgtcctacca attatttgcc atccaccagg
    39841 actatcaata ggatatacac cagtctggga acctgctatt ccaacactcc caccataaat
    39901 tttagtcctt ggcacttcta atctaggtgt agctattctt tcatccatac cacctagata
    39961 tggaaatcca ggagtaaaac ctagcatata tatcaagtac tctctgcttg tgtgtatttt
    40021 tataacttca tctacagtga gattattgta gcttgcaacg tttttaatat ctataccaaa
    40081 aacctcatca taacatactg gaatctcatg tattttaggt tttggtaata ctatactttc
    40141 caaattatct tctatttttt ttaaattctc aatcaaacta tcaaaatcta tttctaatgg
    40201 attataactt atcataagtg acctatatgt tggtaccatt tctgttacaa tacctttaag
    40261 attcgatatt tctattgctc tcataaatga aattactttt ttgtttatat cttctgatat
    40321 ctcatttcca aattcagcaa ccactgcctt atcccctgat atcaagtatc tagtttccat
    40381 aaatgtcacc tcttctaaat taagcaaata aagcacctag gctgctaaga gaagttattc
    40441 ctgtatatgc agatattaaa actactatta atccaaatat taaaagccat gtaggatgct
    40501 tgtaatctcc aacaatatct tttcttttag atgctataag cataattcct aatgtgattg
    40561 gaagtatcaa tccatttaaa gctcctgcta aaattaataa agtagctggt tttcctataa
    40621 atgccattat aagtgttgat attgctataa atgctattat aaaatatttt tcatatttat
    40681 ctataaaagg atttagtgtc tttaagaaag aaactgatgt ataagcagct cctataactg
    40741 atgtaattgc agcagaccat aatacaagtc caaagaattt atatcctatt gctcctgcac
    40801 taaatttaaa agctgaagca gctggatttt ctgggtcaag ttgaagacct tttgaaacca
    40861 ctgccagtat tgctaaaaat aaaagaactc tcatcattgt ggcaactaat atacccaaaa
    40921 gagaagattt agttatttct tttatatttt cttctcctgt tattccaccg tctattaatc
    40981 tatgtcctcc agcaaaagtt atataacctc caacacttcc tccaagtaga gttattattg
    41041 ggaatatcag tccttttgga ttttctggtt ttaccattct tgatactgcc tctccaacag
    41101 gaggatgatt tgatattgct acatatccaa ctataattat cattcctaat gctaaaaatt
    41161 tagttatctt atcgactaga gaatttgaat tttttgacat aaatacaaat atggctatta
    41221 atccacttaa tacagttcct aatgtcatat tcatattaaa cattacattc ataccaagtg
    41281 cagctccacc aacatttcct atattaaaag ctaatcctcc aagagctact aaaaaagcta
    41341 ctaaataacc taatcctggt attattttat ttgctatatc ctgacctcta agtcctgata
    41401 caccaattac tctccataca tttacttgag cccctataaa aaggattgtt gtaattaaaa
    41461 ttacaaatga aaaattcggt ccaaaatctt gggtaaattg tgcagtctga gttaaaaacc
    41521 ctggtccaat tgctgatgtt gccattataa atgcagcccc tataagtgct ccgacatctt
    41581 ttttattttt agttttatct gtaatatttt ttgtactcat attttatctc cccctcatgt
    41641 tatcagtctt atactatgtt ctctgacgaa caaacttcta tgttttctaa tggacaaact
    41701 tctatacttt ctaattcaaa acgctttctt atttctttga caaactctat tgcttttgga
    41761 ttgtccccat gtacacatat agaatctgct ttgatatgta taacttcacc tgttaaagtt
    41821 tctacagttc cttcttttac catcctaaca accctatcta ttgcatgttt tgtatcatgt
    41881 ataactgctc cttctacatt tcttggaacc aaaaaaccat tattatcata agctctatct
    41941 gcaaatactt catttgcaaa cctaagtcca atttctttag cagaatttat catttcacta
    42001 ttatatagcc ccaacagtat aatatcttta tcgacttcat atatagcttc acaaatcccc
    42061 atagctaact ctttatcttt agctgccata ttgtataatg ctccatgtgg ttttacatgt
    42121 tgtatattac atccatttga acttgcaaat gccattaaag cacccaattg atattttgta
    42181 taatctttag cttcctgctt tgttattttc atctcacgtc ttccaaatcc tattaaatct
    42241 agaaaacctg gatgtgcgcc tattttcact ccattttttt tagctagctg tactgttttt
    42301 tccatatgac tagggtcacc tgcatgaaac ccacaagcta tattagctga tgaaatatat
    42361 tttaaaactt cttcatctaa accaatctta tacgttccaa aactttctcc taaatcacta
    42421 tttaaatcta ctttatacaa tttatgaccc ctccttgcta acattttgat agaataagta
    42481 gttttaattt ttaaattttg tttattttat atattgcatg aaatatttta tcacttgtat
    42541 tcaattttat ttttgcaact attctattgc atttaattaa tataatttta ccatttaagg
    42601 aatatttttg caattatttt aattgaacat tcatttgtat ttctttttca aaaaatcttt
    42661 ttaccatttt ttagttaata attaattatt ttcacttaaa ataagggctt taacctttat
    42721 ttttaaagta tttttcattt ttaatcactt tatatgcaag acagaatcat ttttcttcat
    42781 tcatttgttt ctttcatcta tataattatc attctttgta agtaaaatat ctttatattt
    42841 ttataattaa ttctttatat agttttaagt ataataaaat catgtatact aaatgcatgt
    42901 taaaatatta ttttaaaaca tgcacaatat ttgtacatat tgtagacata taaacctata
    42961 aattatacaa tagtattgtt aagattatat atttttttaa cataaatttt gtattggggg
    43021 aaaaacaatg gataaaaact atacgatgcc aatataccaa aaaatagcgt tggatattgc
    43081 aaataaaata tacacgggtg aaatacaaga ggattcagta ctatttggac gctctgtttt
    43141 ggctggtaaa tacaatgtat ctccagaaac gataagaaga tctgtcaaaa ttttagagga
    43201 cattggcgtt gttaaaagca taaagggtaa aggtgttatt gtactatctc cagacaaagc
    43261 ttcttctttt ataaaaaaat atagagatat tacaaatata tcatcatata aatcaacact
    43321 ttataattta atagatacta aatctaattt agaaaatgaa atattagata ctataaataa
    43381 aattttagac tattctaaca gacttgaaat aatcaatcct ttagtgcccg ttcagttcac
    43441 cataaattct aattgcaaat atattggtca aacagctgca caaactaaat tttggcaaaa
    43501 tacaggtgct acaatagttg caattaaaag aggtgaagaa cttataatat ctcctggacc
    43561 atatattgaa tttttagaag gagacattct cttagtagtt ggtgaccaac acatttacaa
    43621 ttctatacca atgtttttat atgaaaacga aaaataaatt atataattta gtatgattat
    43681 ataaaaatgc aaaattaaca acaaaaaaag agcttcatat tttacataaa gctcttttta
    43741 aattcaaata aatttaactt tgattaattt ttaaatatcc aattcatctt ctttttccca
    43801 gcttaaagct ctcgatacag cttttttcca tcctttatat aatttacatc tcttctcttc
    43861 actcatattt ggattaaact ctttttctac tgaccacttt gaagtaattt catttcttcc
    43921 aatatagaat ccaacagaca accctgctaa ataagcagct cctaaagctg tagtttctac
    43981 tattttgggt ctatctatat ctacatttaa tatatctgat tgaaattgca ttaaaaaatt
    44041 attattactt gctccaccat caacttttaa tgattttagt tttaattttg aatcgttttg
    44101 cattgcttct aaaacatcct ttgtctgata agcaattgat tccaatgtgg ctcttactat
    44161 atgttctttt tttgctcctc ttgtaagtcc taaaattgaa cccctagcat acatatccca
    44221 atatggagct ccaagacctg taaatgctgg cactacatat acaccattag tatcctctac
    44281 cctatttgca tacatttcac tatcttttgc agattcaatt atctttaatt catctctaag
    44341 ccattgaaca gatgctcctc caataaatat acttccttct aatgcatatg ttacttttcc
    44401 atcaactccc caagcaattg ttgtaagtaa cccatgctta gatttaacta tgttactgcc
    44461 tgtattcata agtaagaaac aacccgttcc ataagtattt tttgcagtac cttcttcaac
    44521 acaattttga ccaaataatg ctgcttgttg gtctccagca catcccgcaa taggtatttt
    44581 agctcctgat aacatgcgct catctgtatg accataaaca tagctagaag gttttactaa
    44641 tggcaacatg cttattggta tgtccaattc tcgtaatata tcctcatccc attctaaatc
    44701 atttatattg tacatcattg ttctagatgc atttgagtaa tctgttacat gtacttttcc
    44761 acgagttaaa ttccatatta accatgtatc tatagttcca aataataact ctccttgttc
    44821 tgctttttcc ctagctcctt ctacattatc taatatccat tttacttttg ttgctgaaaa
    44881 gtatgcatct attaaaagac ctgttttttc ttttattgat tcttccaatc ctttattttt
    44941 aagttcatca catatttctg acgttctcct acactgccat actattgcgt tataaatagg
    45001 tttaccagta tacctactcc aaacaaccgt agtctctctt tgattagtta tccctattga
    45061 agcaatttct tctggtctta tacctgctgt ttctataact tctctcatta ccccactttg
    45121 tgacccccat atttccatag ggtcatgctc tacccatcca gcttttggat aaatttgatt
    45181 gaactctttt tgtgcaattt tcactatttc gcctttttta ttaaatagta tagctcttga
    45241 actggttgtt ccttggtcta atgccattac atacttcttt tccatcacca tattctcctt
    45301 atcatataat atttaattta ttaaaaagaa aaatttaata tcacatattt caataaataa
    45361 tcatacttaa gtacaaattt aatataatag atatttagta agaagacact tattttctat
    45421 catatctata taataatatt atacattata gcttacatat tgattaataa attttaaagg
    45481 agtataataa acagtgttca taataatttt aataaaagag gtggtaatat gccaaagatt
    45541 ttagaaaatg taaaagaaga tatattaaaa gtgtctcggg atatgatttt agaagaagat
    45601 tactcgaata ttagcataag gaaaatagct caaaggtgtg gtataagtgc aggtacagtg
    45661 tataattact ttaattcaaa acaagaaata atagaatata tcacaaaatc tgaatgggat
    45721 ttattgataa ggcgaattga atactccaat aaaaacactg aagattacat aaaaaaacta
    45781 aacattattt ttactgaaat aagaaatttt ataaacaaag ttcataatat ccaatacaat
    45841 gactttttaa acacttttga aacagagaga ttttttgaaa tgaaaaaaca caaagacgac
    45901 tttcatgaac agctttcaaa taaagtatat gaagctttag aaaaagaaag tttttttaat
    45961 aatgacaaat tagtatgcaa tatcataata aaaatgtttt tttcatattc aacatatctt
    46021 catatagaat ttgaagattt aaaaccctat attgaaaaat taatacatta aggtggtgtt
    46081 taccttgaat cataatacta gtattaagaa caaggacagt aatccaaaaa tatttttagt
    46141 acttacactt tatctattag gtatatttat gggagctatt gatactggaa tagtatcacc
    46201 agcaagaacg attatacaaa atagccttgg agtaaatgaa aaaacgggaa tttggatgat
    46261 taccatatac acattaacat acgcttctgt aattcctatc tctggaaaat tagcagataa
    46321 aataggaaga aaatatgtgt atctagttag tatatttcta tttggtagtg gttcattaat
    46381 atgtggatta tcatcactat tttccaattt ctatatttta ttaattggtc gtgttattca
    46441 agcaattggt ggtggtggaa tcatgccaat tgctacagca gaatttggaa ctaccttccc
    46501 agaaaacaaa agaggcatgg ctttaggttt agttggggca acatatggta ttgccaatat
    46561 tttaggttca agcattggta gcacaattct aagtatattt ggaactcaaa attggaagtg
    46621 gctatttttt gtaaatcttc caatttgttt aatcatactt attggtggag ttttctgtat
    46681 taaaaacaat aagtctgaat ctaaagaaaa aatagataag cttggtacat tgatgttgat
    46741 atgtataatc gtatcactat tatatggtct tatgaatata gactttttta attttaaaaa
    46801 ttctatacaa gatatatcag tttatccata tttattgaca tttattgtac ttatacctat
    46861 tttcatattt attgaaaata gagctaaaga ccctatttta agctttgaat attttttaaa
    46921 tccgagaata ttgatagtac ttattttatc tttaattgtt ggtattggaa tgatgggtat
    46981 ggtattcgtt ccacagtatg ctgaaaatgc attaaagata aatgctggtt ctggtggata
    47041 ttttgtagct atattgggat tatttgcagg tattgctgct cctttaagcg gaagacttat
    47101 tgacaagttt ggggcaaaaa aaatactatt actaggattt tctgtatcta tgataggctc
    47161 tctttaccta gttttaattg ctctaaaaac caatactgta tttagtgtat gtgtaagttt
    47221 aatatttatg ggattaggaa tgggatttac tatgggaact cctctaaact atatgatgtt
    47281 atcaaataca agattagaag aatctaattc agcacttgca acattatcct tgatacgctc
    47341 aattggtact tcaatttctc cagctataat gattggattt atagcacatg caggattatc
    47401 tgtgcaagat aatattatgg acttagttgg aaagccctca actcctaaaa tagttcaact
    47461 tgaagaactt gaaaacatga tagatgactt aaaatcagac cctgaaatgg caaaaaattt
    47521 aaaaaatgtc tctatcccaa atatgaatga tacttcaaat ataaatatgg acatgacagg
    47581 tggcaaactt ccaaaatcct tacttaataa agttcagtca gcagatacaa ccaacattac
    47641 caatataaca aaagaaatat caacaacaat gtttgatgaa aaagttccat ctataattac
    47701 taaaatacag aaaaatgtac aaaaaggaat agatggaaca caaagtggaa taaacggtat
    47761 tgaagatggt gaaaataaac taaatagtgg tattaaagga gttcaaactg gtattgacaa
    47821 tatggtaaaa gctagagctg gtattaatca aggaatagat ggtgtaaaaa aaggtattgc
    47881 tggtgttgac aaaggtataa aaggtatgga acaaggtctt gaaaaacaag atgaggccat
    47941 caaggaactt acaactgctt ataataaaat acctactaca gaaaaaactc ctactgataa
    48001 cgaaaataac tcaaacgaac aaaaccagag taataccagt aattctgaat cagatgacac
    48061 taagaatgat tctacagaaa ataagaataa caattccagc gagaataaac caaatgtaaa
    48121 tgaacaaaaa gaaagtttaa atgctcaaat acagcaacta aaaaagacaa gagatgactt
    48181 aaatacaaag ttacaaaaaa ataaaactca aaagaacgaa ttaagtaaaa aactaagatc
    48241 aatggaatct caaaagaaag agctacaaag caagttaaat aattctataa gccaaaagaa
    48301 agacatggaa aaaagccttg atacaatgca acagcaaaaa aaatcactcc aagcagtttt
    48361 agcaaagaca caagaggtaa aaactgaaat accaaaggct tttgataaat caaaattgga
    48421 ttatataaat tccatagaaa ataatagaac aaaaatagaa aacacactac aatctactct
    48481 aaactcagga tttaaacaga tgtatataac agtattctgt gtaaatctac tagcatttat
    48541 aatattattg ttctataaag aaaataaaac tagataaaag agtgttatag tattatattg
    48601 taaatttatc ttattcttaa atattttatt ctaaagaata aattcataaa atttttgtaa
    48661 ttgattaata taaattacaa tataatacta tttttctctt aatctttttc tcttttacag
    48721 acaatcaaaa agcaatctta gtttatcgaa ataaatttat acaatctatt catacacccc
    48781 tttacattta tataacaatt aaacctattg ttatatatac aaatcaaaat aaaccatata
    48841 ttttcaacta taatatgtta aaatcatatt atgagcatat taatttaagc aaaatgtcat
    48901 ttagacttta atttagtagt tttatattat aaatttatat atttttaatt ttaaatgtca
    48961 tttagacatt actcataaaa agaaaggagt gtattttgtg gatactttag gaaaaagaat
    49021 tgcttatttg agaaactcca aaaaacttac tcagcgcaaa cttatggata ttttaaaatt
    49081 tgaaaactta ggcaagtatg aaacaggaga tagaaaacct aattgtgata tactaatgtc
    49141 aatagctgat tattttaatg ttacgactga ctggcttctc tatggtaaag agaaggtaaa
    49201 tgtcaatagt agtgtaaaag aagataaaga agattactta catgttacta atgatgaaat
    49261 gacgatatta aatctataca gacaactaaa cgaacgtgat aaaataaaaa tagaaggaat
    49321 acttgaactt aagatatctg aatataaaga cttaaaaaag cattcctcta ataataatga
    49381 agataaaatg gtttaaacat acataatttg atacgatttt acatcatcta ttaaccttct
    49441 ttttttgtag tatattacta aaatatggat attggattat ttaaaaacaa gtatagtcta
    49501 atttcaagca catttataat atttagatta tcttatccat attttagttt aagtactttg
    49561 aaaaatataa tacatctcta tgtataactt atattcctaa gaaatgcatt actcatgttt
    49621 ttaattcttc caacatcttt ctatacacaa ttgtacatcc ttcataattc ccctctttaa
    49681 gaaggattga acatgtacta gaatatttag ttaaagtatt taatctttcc atatttaagc
    49741 tttttatatt actgagtgct gtaataaaat catcaattgc tctacaacac tctataaccc
    49801 catctgaatc caatttacac acaagaatat tcacctactt tatatactat ttattaatca
    49861 tcttctgaat attctatatt aagtaattga taaattgatg atttatattt tttacctgtt
    49921 cttcttccat ttaaaatagc tgacaaatag ttttcattaa cacctatttt cttcgctaat
    49981 tccctttgag tcatatttaa ttcaataagt ctttgcttga cttgcactcc caaaaaaggt
    50041 atccattttt ttcgagcatc catttatcaa cttcctttct aagcgattta tatttacttt
    50101 tatattattt tagcttacgc accccctcta tttagtatat atttttaata tgtacacata
    50161 ttaagtatat aaatttattt aatactaaat aagatttttt gattactttg tgctaaaatt
    50221 aggatgtaaa ttcgtatcat taagttaatt ataaagtcat tttgacctta agtcaatggt
    50281 ttttatgtca ttttgacctt taatttgaaa ctatttacat cttaaaaagt ctttttgaca
    50341 ttaattgaat ggagagtgtt tatggatact ttaggagaaa gaattgttta tttgagaaaa
    50401 gcaaaaaacc ttaaacaata tgaactagaa gaaatgttgg gctgtgacaa cttaagtaaa
    50461 tttgagagaa acattagaaa accaaattat gaaatattaa aatctatagc tgagatattt
    50521 aatgtttcag tagactggct attaaatgga gataatctat cacataaatc agatttaatt
    50581 tgcgattcct cctcaaacta tccacttaat agcataaact ctaatgaaat aaagctttta
    50641 aacaatttta gaaaattaaa tgattatgat aaagctaaaa tagaaggtat gattgaatta
    50701 aaacttcatg aatatgaaaa agagaaggat ttaggaaaaa ttgagtataa caaaaataaa
    50761 gatgagaaaa tagataaata atttttatgt tgcttttgat acgattttac atcatttctt
    50821 tgttctaata tttttatttc atttattttc ttttttataa ttttatgata aaataattag
    50881 tatattttgc tttacttgaa tgtaattatt tatacaaaag tcaaacataa tataaatgta
    50941 gtaaattttt agtttcaagt aatatctcgt tattataact aaatatttat taaaattagg
    51001 aggataaaat gggcttaaga gacaaattcg cgcaatcatt tgctagatca aaaactatga
    51061 gtggccctga gaaaaaggct aatgaaataa tgggtaaatt gcttcttaag aaagctatat
    51121 tacctatcgt tttaatgttc gtgataataa tcgctggagc tatgcttaaa atcaattctt
    51181 gggttacact tggcataaat ttagttattg ctgttggtgc tttcttctac ataagaaatt
    51241 ctagtaaaaa gtatcagaac tttaaacctt atgttggcaa tttgattagt ttagagaaaa
    51301 aaggtaaaaa agagtacgtt gctattataa aacaaggtaa gttaccagtt aagttacaaa
    51361 tagcttatgg tggtgaagac cttgaacatg ttaagaaaaa tcaaatggtt caaataagtt
    51421 ataatccaga tgctaaaata gctattttgg ttaatagaca ataatttaat aaaaaaaagg
    51481 agttgtctta aaattgattt tttctaatca aatttaagct caactccttt tttaattttt
    51541 atatgttatt tttattactt tttttaatta atattttaaa tattaaatcc ttctcaataa
    51601 aatagtgaac tatctacaat actactttat cttttcctaa caatatataa tctggtgcta
    51661 ctctttcatg ttatacacca ttttgtaaca taccttttat atcagtaaca tcttccttaa
    51721 tttcctctac atctgttttc attataccca tttgaacaag tatatttttg tttatttctt
    51781 gttgttgtgt agataattct ataaaatttt ctacagtttt tttatacatg tctctatctt
    51841 cttttttctc ctgcatagta tttttaaata atagagcaca tagtatacct attgccccta
    51901 gactactcaa ttcggttatt aatttatcca ttatagcctc ctattgtcta aattttttat
    51961 acttatagct ttaatttttg ttgtattctt acatcatgca atattatatt ttcaggatta
    52021 tcaatttaat cttctgtact ttaaattgta ggtgtaattt atagattgaa taaataataa
    52081 atatatatac aagttctaat gtaacaaaaa ataagtacaa ggcttactta ttaaagttaa
    52141 gaccttgtac tttacataaa aaaaataact aatacatagt tattctaaat ttactattca
    52201 actggtattt ctaattcttt acatctaatt ctaacttgct ctctaattac tgctggtact
    52261 tcttctattg tttttttgcc tcttaaaatt aaagctacat atacttctac cattccactc
    52321 tcacctccag attttcttac actaaaagtg cttatattac ttgcttcatt gacagaactt
    52381 tgatttaaca acatctcata tatttctaca tttgctataa aattatttgt tatatcatca
    52441 tcttgcttta cttgacctat acttatgtct gaaatgtctt tatactgcat ttctactttt
    52501 ctaccttgtt tgatttgttc tattttattt ttatcgaatt taaacaattt tcacacctcc
    52561 attttaagct tgtggctcgt tgttttcagc atcatatcta aaaatcatag atggacgttt
    52621 tatagctgtc catttatctc ctttttctac tatgatttta ggctgagcac tttttatgtt
    52681 ggcttcttct aattcataga tttcttggta acttgagtct gattttttga tttcaactag
    52741 tttcatgtct ttgaataagt cagatttatt tatttttact tgaactttag ttttatttat
    52801 taattgatat ataggattgt tttccatcat atcatccttt aatccctcat ttaatgttac
    52861 tattaagtca gtgttatttt cagtaatgtt tatgattgaa tatactttat tgtttatcat
    52921 taaaatagaa tcctttttta ctttaagccc tgtttctgat ttaaatataa acatacttga
    52981 atataaatcg cctgtaggac tactggcttt aatcagtatc ttattttctc ctaatactat
    53041 tttattttgt ggtatctcaa atataatgct atttatttcc aaattagtct tagtagatat
    53101 taattcatca tttataaaca tttcaagttt ttctataaca ttattagggt cttgtactac
    53161 aactctcact tgagatattg atttttcaac tatttctata gatgctttac ttgtatctac
    53221 ttttgttatc atgtatattg tatcatctga aagctctata tctaaaatat catttagatg
    53281 ttcaggaatt ggtattttag taaattcata taaatcagta attgatatag atattttata
    53341 catagattta tttttaccag ttatccatag actattatca tttttaatta ctagtatgtg
    53401 gtcatcatta tgtgacttaa tttctttaac attagttaat actttagtaa aagttcttat
    53461 tatcttatct ttttcacttt ctcctagtcc aaataatcca tttgtattgt acccttgagc
    53521 gtacaactct ccctcattag ttaaaacaag tgtcattgag ttatatatac ttatatcttt
    53581 aacagaaggt aatccagtaa ccttttgtaa ctctcttaca tcattattgt ggccaactcc
    53641 caattggtac tcagtattct ttccatatga ccatagagta ttatctgtct taataatata
    53701 ggagtagtta tctccacaag caactttttt gacatctgat atatttactt cagtaagagt
    53761 taataattct atatcttcaa gggtttgatt aatttcttta tatgaattac ttcctattcc
    53821 atataacttg ccatccttag caacagccaa tgaatgtgtt tttgatatat caatatcaga
    53881 tacctcaaat ggcaatatta ttgaagtata cttaaaatta tctttaaata tgtttttata
    53941 atttatatac ttattatttg tttttatata cttatcatta aacattacta gcttttcatt
    54001 tttcttatta aaaactattt tatctgatgt gttatctgtt ttaaaatatg aatgtaggga
    54061 accttcaaga gcttcatttt tatcattatc atatctatgg tgaataccta aatgattata
    54121 tctattatct cctgttgaag aataaaattt tccatatata tctttaataa atatagtatt
    54181 gtaactagaa aatacagtat caacatcttt ctttatagat actttataat atggaactga
    54241 catatcccta taagattcat cagatatacc ataagtatct ctacctgatg atatcaaatt
    54301 gttattatta tctatataaa gtgtattatt agctgttaca aaaacatctt taacatcttc
    54361 cacactattt gtattattat tatttgctat acttccatat ccactaagac ctccaacaaa
    54421 tagtttattg tcatttgtta aaatggctga agtatatcca ttaactacta ttttttttgc
    54481 atttataata ttattaatta ctcgtatccc ctttatatca ttagtctctg ttgaaaagaa
    54541 taccctctct tttttccctg tagtataaat catattgtca tttgttataa aaaatgtagc
    54601 ttcacttcct gctgtcacaa cagattttac attctcaata tttatttttg taaatgtact
    54661 tatacttcct tcagtaaacc caaaatagcc atttacaagt ccacatacat agcatgtatt
    54721 atcattttta acaatgattg atacatcatt acatagatat acatctctaa caccatttat
    54781 aggtatacgt gtaaatatat tcctacttgt agtatcaccc aatcctaact gtccttttcc
    54841 attattacct gctccatata aaagaccatc attagttaat aatagagatg tgtttccata
    54901 tacagctaca tattttacat tttcaacatt tattttagta aatatatttc tatttacatt
    54961 atctcctatt cctaactgac cagaattatt taaaccaaca gcataacagg tattatcatt
    55021 ttttatcgca aatgcatgtt tactattgtc agtaaatcta tttacattta tagattttat
    55081 attatcaata tttattttag taaatacctt tctatttatc tcatctccca ctcctaattg
    55141 acctacatca tttaaaccaa cactgtaaag catattatta ttagttaata aatatgtaga
    55201 ctttgaatgg ctatatattt cttgtatatt agaagatatt tcactactgc tattcttttt
    55261 attgtaattt atcttattat ttaaatttaa actactatta actgatatac catgcgtacc
    55321 cttagagtta tatccacata taaataagct cttatcagtt aatattgcaa atctagtttt
    55381 atctctactt aaatcataag gaggtataaa tatatttttt atatttttca ttaccttttt
    55441 ataattagtg gcattatatc catcttgtgt atctgaaaca tctagttctt ttgcactttc
    55501 agatatattc ccaaaaccat atagcgtgtt agaagataaa tacaatagag ctttatataa
    55561 aaatatggct ttatcagagg taataggacc tgaatttata ttagatgctg caatattatt
    55621 agatgattga ttgttaagat aattccttcc atattgatgt atataagatg aacctccaga
    55681 aataagtaaa ttatctggat tgacattttt taaattactt gacgattccc cattatataa
    55741 ataagcaaaa gttgtagaag atgatgattg tgtacatctt gtaggataat aattatatat
    55801 ataagaatca agatatcctg catatgaaat tccctgatat tgaactctat agcttgaatc
    55861 agttggtttt gtccatgaag taccatggta tccagttaga aaagatccaa tgtttgtaca
    55921 aaatacagtt acatactcat atatgataat attattaatt ttagtaatat tattcgtgca
    55981 tgaaactcta ctataacttg accctgatat atttatataa taccaatcac ttaataaacc
    56041 tagatttaca ttagatccat cagaagtact aaaacctaac aggtaatttg tatttatacc
    56101 agttgcatat accttttttt catcaactac aataaatgtt gcattatatg aactataagc
    56161 atcagttaca ttactaaggc taatctcagt atattgactt attaatgcat tactaagtcc
    56221 attaacataa cttgaactct ttccagaagt gtatatttgc ttattattag ttacaattaa
    56281 tgaaaaccag tttgataaat cagtatttat aacaactttt tttacattat ctatagatat
    56341 tttcttaaat acatctgaat tagaaggaag aacacctgct attgagttac tatttggtcc
    56401 agaataataa caagtatcat catttttaat gtagaatatt cctccagaaa tattttttga
    56461 tgctactata gactttacat tagagatact taattttgtc aactcattta attgacttgg
    56521 taagtcagaa cccattcctt tgtatctatt atttcctaga ccatatacat ctccattccc
    56581 taaaataacc agagtacaat aaggactaaa aacgacatct cttacagaat gtatatctag
    56641 tggaagttca atatccttta tttccatttc ttcttttaat aaagttaatt tatcctcaga
    56701 tttaattaaa tttatataat tactataact atatttttca ctatccattt tcttaaattc
    56761 tacaatgtgc atatcatcaa aaaacgaacc taattgtcca taagtattat ctcctgtaca
    56821 atatgaatca ttatttgaat caattagtat gctatgtgat aaaccaatga aaatattctt
    56881 agctacaata ttttttaaat ctataaatga attatctata ttctcagagt aatttgctat
    56941 acctaactga tatatatcat tatttccagc aacctttaaa gtacctttgt tatctataag
    57001 catagtgtta ccatgaccac atgcaatagt ttttatattt acttcttcta tcttagtaaa
    57061 tagtgatgat tgaagtgcat ttccaaaaca tttttccttt ccacaaccat atatatcatt
    57121 attatacgtc attaacacag tgtgttcaga accacaagct atagtcttaa catcattaat
    57181 agaaactaaa ctaaataaat ctctattatt cttatctcct aaacctagtt gaccttgatt
    57241 attaaaacca gtagaatagc atttattgtc attctttatt ataaaagctg atttattata
    57301 tgaaaataca gcctttacat tgtcaacatc tacttttgta aatgtattta catttgcaga
    57361 tgctccatta gttcctagac ctaattgacc atacaaatta tttccagcaa catataaagt
    57421 tccatcattg tataaaagat atgttgattg aagtccacat gcaatatcct ttacgccttt
    57481 tatttctgga accttctcaa atgtagaaac tgttttccct actttttcta atcccaatcc
    57541 catttgacca tctgtattta tacctgcgac aagtaattct ccatctgaag taagtataac
    57601 tgcatgagat tctccacatg caactttttt aatattggta gatatatttg gtattttcgt
    57661 aaataatttt cttgttgtat tgtcttctcc caatccaagt tgaaagttac tattatctcc
    57721 acatccatac aagatattat tattttttag accaaatgta tagttacaac atccagtaaa
    57781 aaaattaata aagtcataat tatcataccc ttcatcaaat tcatcaacta ccatattttt
    57841 atcgccaaag aaattacctc tttgaagtag tttagttctt ttcattataa aaacctccta
    57901 attatcttat ttcatacgaa tatttattta aagttatatc tgtctgacca attgaatatg
    57961 ccctattaga ttttgtttca acaaagttat tatccatttc atgtatatat ctaactctat
    58021 ttgcattaaa tggtagcacc acattcttaa atgtaacact accaagttct ccagttatac
    58081 actttctatt taaatctaac ttaaggcctt ctatagctat tatgttttta gcattagtta
    58141 aggtatcata ccaatatcca gcttcatcta catctatttc tgactctaat tctaagtata
    58201 ttaagatatc taatactttt tcagataatt tattgtaact attttttaat acagatagtt
    58261 cagtttgtat ttgacctcct attacatcat caatagatat atttttaatt ttttctacta
    58321 cctcatttat agctcctgat aagtttttag cttctgtaga taagagttct tcgccaattt
    58381 ttacttttat ttcttttata tttttatcaa acttatcatc taaatcttga atatcctttt
    58441 gagttacaaa aaccaacgtc gggtctactt ctaatgtaac atttgaagta ttggacaatt
    58501 gtaaaatcat ttttacaacc aaatctttaa tactgccatc ttcagcacgt ggcttatacg
    58561 tctctggata cttacctata gctattatat tattctcatt atccagaaca gcagcttctc
    58621 ttatcataaa tccaccaact gttcctggta aaatagtctc tataactatc caattaggat
    58681 ttttttcatc aattcttaga gaatttatat ttccttccca aactacattc tttaaagcag
    58741 tttgttcctc tgttggctca taatattctc cattactatc tccaacttga aacttggtta
    58801 atccaacaag ctctcctagt gcagttgcat ttgctatttt ttctctacca attttggtta
    58861 atattatata aaatttttct tccaattata ccacctccga tttaggataa actactacat
    58921 tttctacacc tgtatcattt gcaatagcta tattaatctt acaattattt tcaatgcatt
    58981 taatgcttaa aggataaacc tttatttctt ctctacttat cattccagct ccacagttta
    59041 caacagcact acattttata attggttcaa agtatggatg aacttttacc tcttcactac
    59101 ataccatacc tccaccacaa tagaccatac ttttatctag tattattggt tctaaatagt
    59161 gtaataagtg agcaggtttt actctttcaa tcatatcgct acaatctaaa agagttttat
    59221 agtcacagtt atttgctata aaactcaata cgaatgtaaa ttcatcacta taaactttta
    59281 tatctgtttc tgattttgta tatgcctcac atatactttt tataacttca atagtactag
    59341 tacctctgct tctcatttta gcttttatat tgctacgtct tgtgtcaaaa tcaagttctt
    59401 ttttttcaat gcagagtatg tcttcccaca tatctaatcc ccatgttgca gtgtcaacaa
    59461 ataattggtt aaaggtatca tcaatatctt ctttaagaat atttaattct gtatcgtatg
    59521 caccttgtat ctcctctaca atgtaatttc tatcaaatga tggtagttta tcaattagct
    59581 tcattgattt tccacctcac taaaattaac agttgttaca ctaggtattt tatcttcatt
    59641 aatagttata ttatctgtac ttccatttat aagtaggtta cttaaatcgt gtacaccagt
    59701 agtatttata agtattccca ttacttttgt atagattatc tctcctctaa tatctctaaa
    59761 gtatgtattt atactttcta ggaaagattc ttttacattg tctaatgtat atccatcttc
    59821 tagtttcatt actgcactta tacttatttc tattggtaat ggtgtcacaa ctgttatagt
    59881 tggtccaata ggcttctctt catctatatg ttgctgacac ctttcaattg tttctgtatc
    59941 aacagcttga ttatttttcc caaatatcaa gaccttaact gttcccggac catcccatct
    60001 tggataaacc ttaacattat agactccatc tacttccaaa gcccattctt catagtgagc
    60061 tttatttcca cttgtagctt gatttctttg gattttataa aatctttctt ttagttcttc
    60121 atctgtctct atatctgtac caccttcaaa acttcttgtg ttagtaatct ttgttactcc
    60181 agatatatta tcaactagtt taaattcaca atttgtaggt aaattatatt tcttaccaac
    60241 ttccagagct tgaactgggc tattgtcacc ttcttcacta ccaatagtta catcttttat
    60301 tactacaaat agtaaatctc tatatgatat tattgtgcca ttatttatta cagtaccttt
    60361 ctctccaata aattcaactt ctccatttga ctctgtacct aactttctat atacaccaaa
    60421 ttcattgact cttttatcaa gaaactggtt atatgtgtct tgtataaaag ccattttatg
    60481 catctttgaa agttctagat atatcttcga aagttctaga ttatttccag ataccatgtt
    60541 gtttagaaaa gaaccttctc ctttataaat atcaagatta atattttcaa gagttctatt
    60601 ttttattact tcatatgtct ggtcactata catttatttc cacctcccca tagatagtgg
    60661 atacttttac atttgcactc aatatgtctc tgttaaagtt agcacttttt acgtttactt
    60721 ctaatatata tggatttatt agaagggcct cttttatgaa tctactagct tcactttctg
    60781 taagaccttt tgtatatttt tgtcctatta gttctgaaag ctctgtccca tattctaaag
    60841 agtatatctc atgttcatat ctatttgtct ttatacactt gtatatccaa acttttaagg
    60901 cttctttttt ttcaattatt ttaaagtcac ctttttctaa aataggttca tctttttcaa
    60961 aatcccatgc cacttcacga aagattggca attcttctgt tttaggtaag atataatcct
    61021 ctgggacacc tataaaagga aatattgtac tcattataag ctcaccaact tacttacaac
    61081 agcaaatttt tcgcctattc taaacattat taccatatcc ccagattcaa agttatctat
    61141 aaaaggattt tttacttcat gctggtgttc ttgatttgtt tctgtgtcaa atgtttctag
    61201 ctgtctatca atcatccaac tatctatcaa aatatcttct ttttctaata tgatgttatt
    61261 tgtctctatt tttaaatctg gtaatttact tttaattttt ccaataaaaa aagaaggttg
    61321 attatgatac tttccttctt ctcttattat tcctataaat tcatttattg gattagccat
    61381 tatatcacca tccttttata atactctcct agctgtgtta aaatctcttc tactacttaa
    61441 cttacttatt ttaactacat cacctttttg tggagcatgt aaaaattctc cattacctat
    61501 atataatcca acatggctga ctggattatg aaaaaatact aaatctcctg cttgaagatt
    61561 tttttgttct actttcttgc cttttttaga ttgttgattt gacgttcttg gcaaactaac
    61621 attaactttt ttaaaacaat agaccattaa accagaacag tcaaaactac ttggtccatt
    61681 tccaccccat ttataaggtt tacctagatg tttttttgct tctgatatta ctattttagc
    61741 tttatcagat acattaccag aataaccacc aataataatt tttccttttc ttcttccaaa
    61801 tttactagct tcttcaacat ttccaaataa aatatctata tggtatgttc cattcttttc
    61861 tatagttatt gcaggtccta cgtcatttac tttatagact ccatcacgac cagaaactcc
    61921 tgtaattacc tgtatttcat ctccatagtt taataaagga tgtttattta aaaactcttt
    61981 tgtataataa gtttgctcat atttaccaac cataggagca gcgcaagttt ttttagatgg
    62041 gtcaagtttt ttctttctac aatctgtatc tccaccttct tcttttctag gacagtaagc
    62101 tgtaaattct gctgtaaact cttttcctcc tgcataatct tctcccccta aattactttc
    62161 ttccttaggt tcatcctgtc ctgctgactt ttcatccata agattttgaa aattaagttc
    62221 aagctcaatt tgatattctc cattttgcca agtatgtttg tctgtatcta tataaaatag
    62281 tcctacaagc tttgtataag aatctttaac ttttactcct ctaccagtta tacaacttac
    62341 atctccataa cctttaagag aacagctttt ttctatccca ttaaactcgc tatcaatatc
    62401 tacatcttga ttttcttgtt gctgaattac tttttgcatt attacattta cttccttaaa
    62461 aatttcatta tctatttttt cgctaatctt gcttccatac tggtctacca ctattacttt
    62521 attttttaca ttttccatgc tctccgaaaa ggtggtattt ataatattaa atccctcttc
    62581 aaacataaca cttaatgtaa cagttccttt ttcaataaca ttaaacttat ctaaattggc
    62641 ctctatcata tactttttct ttgtcttttt acttgcttct gtatatgcac tcattattgt
    62701 gtcataacca tttactccta taaacatctt tgtatacttg acattggtct ttgctattat
    62761 tccaactgaa agcctatttt cagcaaatac ttgctttgct atgtcttcaa ctaacttatc
    62821 tttaaaattg tatgacactt cactttgtgt aagtaaaaat cccatatctt tagatacaaa
    62881 actaatttca ttactgcttg aatctttaga cctattaatt atcattcctc taaagagttc
    62941 tttctcatct acatagaaac agactgtact agctattggt atatcgattt gttggaaatt
    63001 tacatcaaat gatgattgta ttattgaaaa ctctagtgtc cttgatggag atttataatc
    63061 acctgaccat gataccttgt ctactatgtc agttatgtca tatatacttc cgttttttat
    63121 gtgtacccaa atcttaataa taaaaaatca cctgcctttt catttaattc tatcagcagt
    63181 tatttataac ttattatcta taatagttat tgttttggag ttacttttgg tatctttatt
    63241 cttttatact cttttaaatc taatgtaaaa tatacatctc gagtcccatc tctttcttca
    63301 taactaaacc cttcaattat gacttccata tttatatttg tttccgtaat tgtaaatctt
    63361 aatataaaac cttccttcat ccatttttct atcttattta cacaatcata tggtgatgga
    63421 aaacctgtat agtcacagaa agtatagtct ttatttggaa aaaaacttga tattgaaatg
    63481 cttttaagag ctacaccacc aaaagttgct atttcaccta ttttgagtat actagaagag
    63541 tttacagcag cttttccatt aatactaaag gaagatggaa atactggaaa tctaaatcta
    63601 tcttcagctt gtctaagcca catttccatt ataagacacc ccctaactgt gccaattgga
    63661 tacttgcaac taattttgat gttatctttt ctatatcagc ttcttctcta atcactattg
    63721 tatcagctaa cttagctatg tttatatttc caccattttt tctgcttcta tattgatttg
    63781 cttcttgttt agttaaaacc atttcacctt catggagtct ggtttgatag tcattataag
    63841 gaacatagtt caatccaaat gcattattac ctttcttacc tgaataagct ttaccagaat
    63901 caccagcctt tgttccagca tatggattat ctttgtaatt ttttttactc ttttccacta
    63961 gatttaaaac tgttcctgtg atgcttccat tttttatctt attaatcata gtttgccacc
    64021 atttacatat atctttaact attttacata ctttatctaa tatgttaaaa aaagctccca
    64081 atattggctc tataattttc catccagttt ccaacagagg tcctaaggtc tcccatacag
    64141 ttttccaaat aacacccagt gtctctataa aattgtttat ttgaggtgca tattcaccta
    64201 aaaaagtaaa aattcttgtg ataataggac taacagcttc aactacaggt ccgattagtt
    64261 ggaatgctgt agttactatt gtaccaaata tacttattaa tccttgtgca attggtgatt
    64321 tattgtttat actatctagt aaattattta ctaagtttac tactggaagt aatgaatcta
    64381 ttaatgctgt aaaatcgata ttttgtaata gtgtacttcc tgcgttaaca attgcttttg
    64441 gtgcattccc tatcattgtt gctgcatgat tttcaaaacg ttcttgctta ttttcaacca
    64501 tcattttacg cttttcagcc tcattagaaa ttcgatattg agtagaatca gaaaactctt
    64561 ttccattttt tacacttcta gattgcatct ggtcatattt gttgccaata attatcttac
    64621 cattcattac attgcctatt ttaccagcca ttttttcaga taagccagct aaattgccta
    64681 atccactttc tataaaagtt tttattttct ttagtccttg acctaaaata tcatcaaaag
    64741 gtttaacaat actcttcaag ccattgttaa tgcttgtttg agctcctgat attatacctg
    64801 gtattgtatt actcatttct ttagctaacc ccatctgctt tacacttatg ccttccaatg
    64861 cttcatcaaa agttttataa ttttctccta ccagagtatt aagagattcc atgtttcctt
    64921 ttgctgcact taagaaagct gctgatacat cttgttcact acttgtattc atatttaaag
    64981 ctctaacatc taccatagct tgagttatat ctttttcttt tttgccacca gtaatattac
    65041 taatcatttt agctttagtt cccattgcaa caacatcttc agggtcaaaa ggcgtatcat
    65101 ttgccattct tactaaactg ccataataat catcaacatc tatttgatta acttttccag
    65161 tatttctttt cattacactt tctagaacaa ctttctgatt ttgttcctga ccaagtaaat
    65221 caacaccctt tttcacagcg acacctatag tagcaccatt tgtcaaatca gatatcttcc
    65281 cttttatcga accaagtatt ccacttgcca tatcctttac agctattgca ccactccata
    65341 ccttacctgc aaataatctc aatttgggaa atactttact tataatgcca cttgccatat
    65401 cttttatagc tattacacca ctccaaaaag tatttttaaa caacattaac ttaggcaaaa
    65461 ttctacccat agcactactc accatatctt taagattaat acttccttga taaggacgtt
    65521 tctctacttg ttttaatttt cccaagatac tacttatcac tctcttagtc atatcttttg
    65581 cttttattac gatattccaa atcttgccac caatcttttt taaatttcca agtaatttat
    65641 ttttagtttt ttctacttca tcacttttag ctttaaatat taatataatc ataatatttg
    65701 aattaaactc atttttcttt tgaatcaact tattaaaata atcaataatc atagctatag
    65761 ttattgctag tctcataata cttccattta aacttccaat aactcctgaa acagcattta
    65821 tgctagaact taattttgtc atagttgaac ttacactact agcagtagtt tgaacttttc
    65881 ttaacgagga atttaaactg tttactctat tacttgcact tccaatagaa ttttttatgc
    65941 tactagccat tacattagtg gaaagtgaaa cagccacagt tgctctccta aaattatcag
    66001 ttactgatat aatttgattc atttttggtg tgtaattatc tgtaaggtac atatttatac
    66061 cttcttctct cacatttccc attacatacc acctcctgtc aaaggacaca ctccatatcc
    66121 atgtttcatt ttttcaactt cttcctcaat ttctaaggcg aaaaaagctt caataagctt
    66181 taattcgcct ttatccattg cataaaaaag ggacggtctt ataccttttt tcttccaata
    66241 atagtacatt attgtagtcc tggtatccgt ccctattagt tttttacctc ttctatcact
    66301 gcatttttac cataacccat aacatcttga agtattctat ataagttggt aatttcacct
    66361 ggtaataata attttcttgc taattctttt ggtgttggag ccttaaattt atccattagc
    66421 tccttatttt taaataaaag ctttccatcc aaatcacaaa caccttctat aattgtaagc
    66481 atctgcatct ccggtaagtc tatatccgtt ttcatatttt catcaatttt aagacaagta
    66541 ttttgtattt cttcatcttt acttattgtt aaagctctac acattacttt aaattcctgc
    66601 ccaaatatag ttgataatct cttaagttca actatagtac ttggtctttc taagttttct
    66661 gtatctgaat ttaaaagtaa atctactatg tttatatttt ttgataatcc attttcactc
    66721 attattattt gctcctttat caatcaaatt caatcaacta acttttttac ttattaacta
    66781 tctgaattta ttaagtatat acttactaaa tatcagtata aaactaaata taaaactaaa
    66841 ttatatcaag aaaatcatac tcagtaaatg tgaaaggagc ttctatctct ccttttactc
    66901 caacctccca atcagctaaa gttaaatcat caaatgctat attttttact gctattcttt
    66961 ctgctccata agaatctggg tcatttaatt ttgatatagc aacaaatcta ggttcagaac
    67021 ctctctttat cttttctcca attaacttgt gcattcttga actaacgtgg tatagagtta
    67081 ttgagccttt tcctttatat cccatatact ttgtatcagt acccatttga cctgctatta
    67141 taatatcttc ttttgtaaat tccatctttg cttgaaattt ctttacttct gctactttgt
    67201 ttccatcaag ccaaagttct ccccaagtac cactcattac atttctagct tccatatttg
    67261 ccatattaat aatcctccta tatttctatt gataaatcta tatcttccat agcatcaagt
    67321 acttttattt ttgcttttaa aaatacttta gaacctgtgt tagcttcttt tatttcttgt
    67381 aatgtcatat aagataaatc tactcctttt gattttaaat acgatttttg tgcttcaaaa
    67441 tctatttcaa cagtagaatc agattctata agtgctgatt tttctaattc ttctaaataa
    67501 ctttttatag ctactatcaa taaacatttg ttgtcataac tgttagtaac ctttcctata
    67561 tagtcatcta ttatcacctt tcttatgtca ctatgtataa tatctaaagt gtcaactatt
    67621 tttattttct ggaacatttc tcctttttct gctgttaatt cagttaaaga atttactcct
    67681 ctagcaattc ttatagctcc tgcttcttta ataagtataa gctctccttt attaaccctt
    67741 gattctgcat caactttcgt catcttaggt atatcgacta catcactaag tttagtataa
    67801 gttactgatt gacttaaagg tgtacctgct ataagtccag ccaccctgct tgtaaactca
    67861 tcaacactgt atttcttttc tccaactaac acatcttctg tagtaaaatt aattatccct
    67921 tcatgatttc ctacaacttt tcctaataca gctttaacct taaccttatc tatatctcta
    67981 agtttaatta tccaattttt tatagcagtc ttatcagctt ctactgcttt tggcatacat
    68041 agataattaa attccttagt ctctaaaaaa tctaatgcag tttgaatatc tgcttctcct
    68101 tctattacat aaactaataa tttatttgga gtgttaacat ttcccatcaa agctaaattt
    68161 atatattctt tattttcagc agataaatca actggtatat cctctttttc atgtatttca
    68221 ttaagaccta gtgccttagc atctttaagt accattgcaa ttattcctct agctgaacgt
    68281 tctttaacag ttgtagctag ctccttaaat gatatgttga tacttggtaa tcctatagcc
    68341 atactatcac tctcctaaat ttaaattgat ttctttcata ttttcatata ctacatcttc
    68401 ttcatataca ctatccagat agtttagtgt aaatgtaaag ttcaatacat aaattgactc
    68461 ttctttttta atactttgtt ctagctttgt tatatttaat tttctgtctg ttacctttat
    68521 atttctgtta aatagcttat ttaattcatc tgaaatttca tacattctaa tactctttga
    68581 ctgtggtttt ggtaagtatt ttatagagat aacaatatct ttgttattcg tatttaacat
    68641 tacaggtgta caaataactg atagtatact tacaaaaaaa caagaccctt cagagccttg
    68701 cacactttca tcatcaataa aaatactttc agtaaagttt tttttgagaa tctcaataat
    68761 tgtttctaat atttccttgt atttaagcaa ataatcacca cactatcact aaatattctt
    68821 gcttaatctg ataatcttac tataaatgat ataagtcatt tttaaatata tatctcattt
    68881 attcctgtca agtatcttct atatttttag gtaatattat tcttttcaat ctatcacctc
    68941 cttcaatatg gatttctttc acaataacat tatctcacat attttattgc ctattgttgc
    69001 aatggtgtat ataaagtgtt gtaaaattgt cctatttttt ataatatctc actcaattta
    69061 aatatcatct ttttctttaa attgtagcaa gatgttctat ctaagtgtag tttcatagaa
    69121 atatatgtca tattgttttt tgtcttacta ttataaaaaa gattaaaaaa ttccatttct
    69181 atatcattta gacacgttag agcattttct atcttctctt tttctatttc tatatcttct
    69241 ttttccattt ttaattttct taatctttcc tctcttttta acacctcatt ttccacagaa
    69301 gagcttatgt tatatgtgtt actagtcttt tctgtatata ccattgctcc acatccagag
    69361 tattcattct cacatctttt tatgtccaag ttaatattct ttatctttat atccaaatac
    69421 ttataattat gtaatctttt atctgtttct ttaaataata tatctttttt gttttccata
    69481 gtacttcccc ttttttatat acttattatt agcttcaaat ttacaataat ctctttagtg
    69541 cacagttttt tactaatctc acaactttca agaacatatt gttctataac tgtataaaaa
    69601 aaacttcttc tatattttgt tctaaaatac tagaaatctt cttagccata agaagtccag
    69661 gattttttat acctctttct atttgagata tataatcatt tgtaattcca gcctttctgg
    69721 caagttgaat ttgtgtcata cctttgcatt ttctataata tttcaagtta tttttaaaca
    69781 ttgttttata cctccattac tattaagaat attttgttct tcctcactta gattatatag
    69841 aattatttgt tctttatcaa tagattttag aaaaaaatat tcttttatat tttattagtt
    69901 ttatttttta gaacaatttg ttataatcta tacataaggt ggtgttataa tgtttgccaa
    69961 aagattaaga gaacttagaa aggaatttgg attgactcaa agagaacttg gagaaaaagt
    70021 aggcgtttcc caaagagtct tagggtacta tgaaacagaa aacagatttc ctgatgaaca
    70081 cattttaaat aaattggctg atgtatttaa tgtatcagtt gattaccttc ttggaagaac
    70141 cttagttaag gaaaatattg atacagtagc tgcacataga aaaaatccac atgaagagtt
    70201 acctgaagaa gcacaagaac aacttaatga ttatatagaa tttttactaa ataaatataa
    70261 aaaaaaataa accatatgat gagcagtcta tttttctgct cttttaatat aatttaaagg
    70321 caaacataca ttctatttta gggggatttt tatgaataat ttggataagc tttttgaatt
    70381 agcttctcaa gaagagataa taattcatta taccacttat attgcaggtg atttagaagg
    70441 actatatata aacaaacatg gtattaaaat tatatcatta ctcagtaatt taaaacaaaa
    70501 ctcaaaaaaa ttgacatcca tcttagctga agaacttgga catcatttca ctagccttgg
    70561 atactatgta tcctcttata acgattatta tacaaaaatt attatagata agtgcgaaaa
    70621 taaagcctta aaatgggctt gtgagttctt aattactgaa gaagatataa taaacataat
    70681 taactctggc atcacttgcg tttatgaaat ggcagacata cttaatgtgg atattacttt
    70741 ctttcaaaaa agattagaat ttctatcatt aaaaaaacag tctttacaac ttggaaataa
    70801 taaatattta atattaacta atttgccgta tttctacata tttgatccaa tttcataata
    70861 aaaatagtag taattttaac tggcttaaca gtaaaatcta tatatttatt ttaacaaatt
    70921 ttggtttcta taaattcaat attaatatat aataatgata tcatattatt taaaattcta
    70981 aaaacaaata tatgcttttg ttaagaaagg ttgtttgatg aatgtataaa gaaaagttgt
    71041 ttgataatta ttttaagttc ttagcactat tattttggcc aattatgtgg tataagtgga
    71101 tagtaatttc aaatggtact cttgaaaata tgttatttac catatatgca atcgtcgcaa
    71161 ttgttttcat cattttatat tcggtgttta tgataaaata taaagacatt acacaaatag
    71221 atttctttta caggataagt actctacttg cttttatatt tacacttttt agctttttaa
    71281 tatacccaaa gagtttattt ttcttgtatt taaagattat ttttactgga atataccttt
    71341 attattcaat agtaaaaact cttaaattta aagatgacga aggtgtagtg ggtattatga
    71401 gctcactttt attaattgta ataactttgt tctactaaat ttaattctat ttgacttaat
    71461 atggctttaa atattagaca tctacattat tttctgatat tatttaagat ggtagtctta
    71521 tattaataat gaaatacact atgaaggagt taactattat ggaaaaaaaa gttttagcaa
    71581 cagttggaga aaaagagata actaatattg atattgaaaa tgcattaaaa tcattagacc
    71641 cttatcaagc tatgcaattt aaaactgaag aaggaaaaaa acacttatta aatgatttag
    71701 tgaatcaaga attattcttc ttagatgcta aagaagaaaa attagatgaa gaagaaatat
    71761 ttaaattaga aatgaaaaag atagaagaaa atgtattaaa gcaatttgct ataaataaag
    71821 ttttatctag tgttaatgta acagaagatg aaaaagtaaa attctttgaa gctaataaga
    71881 gctctttctc taaaccagaa agtgcaactg ctaaacatat attagtagat agtgatgaaa
    71941 aagctaaaga aatacttgct caaataaaat cagaagaaat atcttttgaa gatgcagctc
    72001 ttaaacattc ttcttgccca tctaaagata tgggtggtga tttaggaaca ttcggtagag
    72061 gacaaatggt tcctgaattt gaagaagctg tgttctctat ggctaaaggt gaagtaagtg
    72121 aaccagttaa aactcaattt ggataccata taataaaatt agaagacctt caagaaagta
    72181 cagagtctac atttgatgaa gttaaggctg aagttgaaaa aagtttatta tatcaaaaac
    72241 aaaatgaagt ttatggaaat aagataaatg ctcttaatgc taagtacgga aaccttgtaa
    72301 aatacaacga ttaatcataa ggtcatatat aaaaaagctg tcttttcaca atatttatta
    72361 gaaaagacag ctttttatat taaagtttaa atattcagtt tcatattatc attcttttat
    72421 tgtaaagaac tcagcttaaa agtttaaata agatttttaa ttatcattag ctaaattttt
    72481 atatccacgt attatctcat aacagtaacc tattacatct cttcttttta ttatcccaat
    72541 aaatgtgtct tggtcatcta taacaggaat gaaattttga tttaaagatt ttataactaa
    72601 atcttcaata tctgcgttga tggaaacagg agaattatcc atttttctat ttatatctgt
    72661 cactggaaca tcttccaatc cctttaagtc cagatttaaa tcatttttta atgtccataa
    72721 aaaatcacct tctgttatag ttccaacata tttaccatcc ttacttatta ttggaattgc
    72781 agagtatttg tgatattcca ttttttctag ggcttgcctt atagtgtagt cttcatatat
    72841 atatgctact tcactttttg gtgttagaaa gaataatatg ttcattacac tacccaccgt
    72901 tactgaaaac ttataaatat tactcaatat ttataatgtt acttttttgc agtaactttc
    72961 tcctttctta ttttctaagt attcttaata ctatacgctg taacaagcgt ttttcctttg
    73021 ctcattttaa tcttattatg ctttattaat atttttatat ggtctatcag tatcacttat
    73081 tctcttttta gaaaatttac taaaaattaa ttgacttaaa cttagccata ataattttac
    73141 tctacactat taattttaac atatttatct cattattaat gattttattt taataatttt
    73201 aatttatttt gctattaatt ttatttacaa aaactgaaaa aaccgctaaa tgattagcgg
    73261 cttatctctc atattactag aacactaata tatatgaatt tttaattata atctaactac
    73321 gttagcagct tgaggacctt tagctccatc tactacttcg aactcaacgc tttgtccttc
    73381 ttctaatgtt ttgtatccat ctccagttat agctgagaaa tgtacgaaaa catctccttc
    73441 accttctaca gatatgaatc caaatccttt ttcgttgtta aaccatttaa ctacaccagt
    73501 tttcattaat aaatcctcct aaaaaaacac aaatatttag ctactctttt ctgtaacctt
    73561 attactactc tatcatatat agctatgttt gtcaattatt attattttta tacattaata
    73621 atcaattttt ttactttata attttaaatg attattatct tttacacttt atttttcttt
    73681 ataatttttt aataatttat ttttattata tggaatctta tggacttatc actccaacct
    73741 aaatcccatg gcaccaacat tctatcagta ttatgacaag ttaccaaagg ataccctctt
    73801 gagtctaatc ctgtcactgt cgaaacatgt gttattctgc ctttcttctc ataaccaaca
    73861 aaatcccctg gacgtaaatt ataagcttct ttgtatactt cttcatagga acctttagca
    73921 attaatgaac ctcttccact atacagtgca taatttttaa aagcttgtgc atttacccat
    73981 gcttttgtac ctgctctctc gctataattc caaattgagt tctttttgaa ccttccactt
    74041 tcaaacatta tctgtgatgc aaagtttgca caatctccac cttctggatt ataatcccta
    74101 tagtttggat taaatttcat accatgttct tcatcagctg cggctccaca gtatttatgt
    74161 gcataatcta tagccttttt ttgttcatct gtaagctgta actctacacc atcttgttga
    74221 ccaatataat ttcttatatc atcagatttt atattttcta aatttaaaga gtctgcaaaa
    74281 gggtctgtat accactcttt agttatgaca tattgattat ctataatttt tacatttaga
    74341 taatgatatg tacctattct aaaggcattt tctttgtcct tttgattttc atatgaatac
    74401 ttatattcag tcgatactga acagattata ccatagaggt ctttttcttt ttcttttatt
    74461 tttttaatct taacccttgt ctttatgtct ttaaatttta caccttgctt actagaccaa
    74521 ttttctaaat acttcatctt ttttacttca ttttcataag cccacagacc aaatttttta
    74581 tccgtctcat aaagaccttt taaaatgttt tcatttttct ctaatattgc cttatttctg
    74641 taatcaaata agttttcaag caatagttta tattggtctt ttacatcatc accttcaaca
    74701 tttgcagatt ccatgacttt ttcttccata tttttcatac ttaaatcatt gattaaaaat
    74761 acacctgctg tagtagctaa agacaaaaat acaaatgcca ttataccttt gatgtactta
    74821 ttcttatttt tcagtatttt caaagctaca cctcccaaat agtacacctt acaaatcaaa
    74881 ttacaaagaa tattctgtca catatagtaa ttttcatatt taataattct ctattttatt
    74941 atgtccaata ttaaaaatta attgtatcaa tacactgttt tttttacaat tttttatttt
    75001 ataatctact tttttctttt ttttatagta atatatatgt atataaatat tttggtatca
    75061 ttataattaa tacatactaa tggagggttt tttatgcaaa aaaaagtcgc agcaattaat
    75121 gacttatctg gaataggaaa atgctcatta tcggttgcta tacctatact ttcagcatta
    75181 aaggttcaat gttgtccatt tccaacggcc atactttcaa gtcaaactgg ttatcctgaa
    75241 tttacttttt tagactttac cgatgaaatg gtaaaatatt caaatgtttg gaaaaattta
    75301 aaagtcaatt ttgatagtat atatagtggt tttttgggtt caaagcatca aattgagata
    75361 gtggctaatt ttataaacga ttatcccaat gcttttatcg tagttgaccc tgtgatgggt
    75421 gataatggag ttatgtatcc aatattcaca gaagaaatga gacatgaaat taaagaatta
    75481 gttaaacatt cagatttaac tactcctaat ttaacagaag cttgtttctt aactggaaat
    75541 gattatacca aaagcgatta taatagagat gagcttatat atattgcaaa atctgtatct
    75601 gatttgggac ctagcaaagt cgttattact ggtatattag aagatgataa tatattaaat
    75661 ttggcttacg atagagataa tgaccatgta ttctttacat cagtcaaata taataattgt
    75721 tcttatagtg gaactggaga tatattcaca tctatacttt gtggtatgtt agtaaataaa
    75781 catgatttgg gagtagcggt taatactgca acagatttta tatataaaac tataaattac
    75841 acatctcaat ttgatactga tagaaatgat ggagttatgt ttgaaaactt tttatcagat
    75901 ttaactaata tataaagtca aaaaaactat ccattttata aatacctata aatcataaaa
    75961 tttaggtatt tacaaaatgg atattattta ctaaactatt ggtatttcaa ttgttaccat
    76021 agcaccacca gttttcacag aattttcaat atataaaatc ccattatgtt tttgtacaat
    76081 attatttaca atatagagtc ccattccata atgagattta gaatttctac tcaaatctcc
    76141 tgtataaaac tgttctgtag cttttgacaa atctgcttta gaaaaaccac ttccacaatc
    76201 tgtaactaca aattttaagt atttattacg tactgataca cttatgtata gtttactctg
    76261 gcttggtgaa taatctatag catttgaaat tatattcata atagctctga ataacagttc
    76321 tctatctata gttatatttt taggcaaatt atcttgttta taaaactcca catctaagtt
    76381 tttagtacta gctaatgctt ctatttgcac taagacatct tttataaact cactcatact
    76441 gattgcttct ttatttaata tatagccatt ctctgttttt gatatatcta ttaaagtatt
    76501 aatatatttt tctatttgag tgacaccctt tgagatatat tccatgtatt ctaataactc
    76561 aggattttca tttatttcaa ttaataagtc agtatttcca tgtataattg ttagtggtgt
    76621 ttttatatca tgtgccagtg cagatatctg ttcctttcta ttttcttcta gcatccattg
    76681 tttttctaaa gaatctttta acgccaactt cattttatcc atagaaaaaa ggacattatt
    76741 aatttcataa attttactag attctacaac aaaatctaaa tcctgttgtt ctattttttc
    76801 tgtagtattt tttaaaagct ccatttcaat attaaatttc ttgccaaata cttttgataa
    76861 tataacaatt tcaataaaaa atattatact aaaaataatc atacccaatg tctctggttt
    76921 tggtaaatat gctcttaaaa ttggagaact atactctgat actattttgt attttattat
    76981 aaaaacttca tctttcttaa aaaactttat ataactttct gaatatgcat gcctttcttc
    77041 aatatctctc attaaattcc atacttcttt tgattctttt ttattaaagg tccctgaaat
    77101 taaactccca tccaaagtat aaaccccata ctcatatata cttggaatta tatcttcagt
    77161 tactttttca cttgaaataa tctgttcttt atatttatta aattgttttt ctgcataatt
    77221 agctggtaaa attacacctg atgataataa tacagaaaat gataacatta aaaggagtac
    77281 aattgaaatt gtcataataa agaataaaga taaatatttt ataaaaatag ttcttaactt
    77341 ttcaactttt ttgttgttag attttttacc tccaagcatt tgtaccctgt cctccaatag
    77401 tttaattaat tcataattaa tatctaacca gttttttatt tgattatttt atatcttttt
    77461 attgctaagt tatattttaa cataataata taaataaaca gtcaattttt actctattct
    77521 tctgattttt taccttccca tttagaaaac caaatacata aaattacaaa tgctaaaatt
    77581 gttacaaaac cacacattaa acctgttgat tgatatgctt ttattgattc aacctttata
    77641 tattcaaccg ttttagaact cgaaaaagac gaccaaatag ttataaatct aacaccccat
    77701 gcacaaggaa aatactgcca aataccagaa cccaatccag ttaataataa tgctgaaagt
    77761 aacatttcaa ctatacctac tccaattgat gttccttttc cgaaccttaa acttaagaat
    77821 aaatgtaata tgtattcaaa taaattacac ccaattaaaa ttagaattga aatcatataa
    77881 aagcttgatg caaagtaagc cttagatata ccaaatttaa aacctaatac agacactaat
    77941 gttgctacaa aaccaagaca tactaagatt atatatttac ttataagagt aagatatttt
    78001 ggattagatg ttgttaacat atgtttataa ttccctgcat aatattcttg ttcaacaaac
    78061 attgaacaca caacacctga caataaagga aaagctattg ctataacttg taaatatgct
    78121 actatcttta gtatattatc agctcctgaa accttataat accataaaaa caatcccatc
    78181 cccattaaag caatgcaaat gtgcattagt attataaaat ttctctttaa ttttattaaa
    78241 tcagaacaaa atattcttat taactgtctc atattacttc acctctctat tattgaacca
    78301 aacccttgta gctaaagcaa ataatacaaa taaaacaata gatattaata ctcctggcaa
    78361 aataacagca ttatttaaaa attcacttcc ctctggtaca ggaagaccat ttggcagaat
    78421 atgcaataca acagccatta atcttgaagg aatcgaatat ggaaacatat accacatttc
    78481 tgtagttgag aaaacagcaa ctccaacaat agtaaagaac atatttatta gaactgtaac
    78541 aaatatacca aattttgaag ctaaaaacat acaaagagga atctgccaca taaatagtaa
    78601 aataattaat atagttgcaa tgatattttg acctattgaa atagtttctt tatagattat
    78661 cccaacaaaa actacaccta ttgcagaaat aattgatgct ataaaacaac aaataataca
    78721 gtaaatcatt tttccagtcc aaacgtcttt catttcaatt ggcaatggta aaataccacg
    78781 atatttactt ttttcatctt ttaatactat taaagaagat attaatgtta atgctcctgg
    78841 aagaaatgtc gtataccacc agttgaaagc agcattttgc cctccaccta gtccacataa
    78901 aagtatacaa aacactggaa ctatccatat caacttcatt ccaaaagttc ctttcatctt
    78961 ttgaaattcc actctaataa atctttccat attactgccc tctctttcta ttttcagcta
    79021 caactttcat aaaaagtttt tctaagtttt gttcttttga tacttctcct tgataaccca
    79081 ttactccatt agaaattatt cctatttcat ctacaacttg ttcaacttca gacaagatat
    79141 ggcttgataa aataactgta attccttgtt ttggaaaaga acgaatcaat tctctaagtt
    79201 cttcaatacc aatagggtca agaccatttg taggctcatc taagattaaa agttttgggt
    79261 gatttaataa tgcaatagca ataccaaggc gttgcttcat gcctagagag aattgacctg
    79321 aacgcttttt aaaggtatct cttaaatcta cagtctctaa aacttcttca atgcgagagt
    79381 caggaagacc aagtaaagta gtatggactt ttaaattttc tcgtgctgtt aaattctcat
    79441 atatagcagg agactcaata agagaaccaa tatttgataa atcctttcta gtccatctat
    79501 gtccctcaaa cattattttt cctgaagttg gatttaaaat cccagttatc atttttaata
    79561 aagtagattt cccagctcca tttggtccta ataatccata tatagaatta gatttaattg
    79621 ctagtgaaat gttatcaact gccatctgct ccttaaattt tttagaaact ccttttacct
    79681 gcaaaatata attactcata attttcatcc tttcttttgt caaacttatt tacaagaatc
    79741 attctaaatc ataaatataa ggattttata agaattaaaa aacaaaaaaa gatgtgttaa
    79801 aaacacatct ttttttatct taattctatt aattttccat tgtagtatat ctctacttct
    79861 tcaatccaaa tgctattatc ttcttcttgg atgacatttt taataatatt atttatagta
    79921 tatattatat tttgttcatt caaataatca tctttccaag aaactctact ttttttatct
    79981 ggttctatca agtttatttt aacaagatta tctttttcct taacttctac ttccatgtct
    80041 aaaccattaa aatactcatt tgataatgta tctaagatta atcgcagttt atccttaagt
    80101 gaactttctt catcaatctg taagtacttt actattttct catcctttga aattatctct
    80161 ataggtattt tagtagtttt tttagaatta atcattttac tagttgtttc ttcttttgca
    80221 tcttcatcct tctttacaac tgctgattct ttagaatcaa ctagctcaac tgcactgatg
    80281 ctataatcca tacatgccgt actcaataaa gtagtagcaa ttattaaaaa acttactgct
    80341 attttattca taagtatccc tctcctaatt ctctttcgat acttattata ccatagtata
    80401 gattatattt ttatactttt aaatcaattt ataaattatt atagtaaatt atttacaatt
    80461 ctaagctatt tgaatttatt tttatagtat attctttctc taaattcgac agatttttat
    80521 tcaaaagccc ttttatttct ctcgtatttc tatacttgtt gctatgttct tcactatgtt
    80581 cataatcata tgaatcattg tcatattctt catcattatt aaattcttca attgcttctt
    80641 ttgactttat atcacaatta aatttatact tatttactgg tatatcaagt cttaccttag
    80701 aatttggaac ttctatgtcc aggaacttag caattggcat atcagagtac aagtaaaatt
    80761 cactttcata atttgaattt ctacctattt tctcttttat atttacattt tcaggtatat
    80821 actcttctat attattgata aatacatctt cattctctga agatatatac aatgactctg
    80881 attctatgtt tacattttta acgcctaaaa ttgattttgt tgacaagtga agattgttat
    80941 tagatattaa gtttaggttt tctaatctat ttactttgtt ctctgttata gctctactaa
    81001 aacctccata agaagtttta tatgttatag tatttgaagc tacattatcg tatacaaata
    81061 agtgtgagct tatacttgat gcatttatgt ctacattatt tggtacatat attataattt
    81121 ctctataatc atgtgaaaac atactattta tagatgtatt taataattgg tcgaaatttt
    81181 taatcttttt aattttattt tcatattttc tttcaccttt tacaactaaa gtcttatctt
    81241 ttaaagttac attgtatttg taaaactcat tatttcctct tgttgttaca cgcacatctt
    81301 cacttgaact tttctttatt gtaacgttta tattgtcaac agctatatct aacttgtcaa
    81361 tatttacttt ttcttgataa agtttatttt cttttttaaa ttcagcttcc ttttctaaac
    81421 caaagtttat taggcttggc ataactaaaa tccctgacca tgttgtccct attataccta
    81481 ttaccaataa aaccgcagca aatatagcaa gttttttatt catgtttatc ttctcctttc
    81541 ttattttcta tatcttcaag gtccttatat atcgcctcaa aatttatact atcatcatta
    81601 tattcatcag tttcttttat gctttcttct tctctattgt agtaatcatt attatatgaa
    81661 tcttcattaa tgtctttatt caaatcttca tcatttaaag tagctttttt tcttttttcc
    81721 atcttttcat ttgcttttat ataaatattt tttctcttta tccaatgtat ataattattt
    81781 agtaattgtt tacctagttt tatggcaaat aataaaattt gccatgcaag tatctcaagc
    81841 cctacaaatg ctatggttgc gaaaatacaa aacatcataa catctggaac cattgctata
    81901 aatttaatca caaatggaat taatataaca aaagcaatta atgagcatac taatgcaata
    81961 gtagcagata caatagcaca tacaaacgca aatgctggaa caattagaaa taaagataac
    82021 actactaata acccctttat aacttgtctg gataatcctc ctacaccttc ttctatactt
    82081 ggtgtaagtt tatcatttat attttctttt gatttattgt acttttcctt agcttcatct
    82141 ttcaagatag aataatcctt ttttacattt gatttaaatc tactaaattt accatttaat
    82201 atgtctgtat tcattatttt tccatctata ttttcttttg atttactata cttttctttt
    82261 gcttcatctt ttaagataga gtaacctttt ttcatatctg atttaaattt actaaactta
    82321 tcattcaaaa catctgtatt tattattttt tcctcttcaa tatttttttc tttagtttgt
    82381 aagataagtt cttttgctat agattttggt gagccaagtg atgctattat ctccatatca
    82441 ctctttccct ctataagacc atctacaaaa tactcttcat aatctctcaa tatatcatta
    82501 acttcgctct cagaaaaatc tttttttaga taatccttta aaatttcaag aaactcagtt
    82561 ttattcaagt tcattacctc cctcatcttc acttattaaa atctcaacag cctttacaaa
    82621 ttctctccac tcttccatca gattggataa attctctttt cctagtgaag ttattctata
    82681 gtattttcta gcaggacctt cattagattc tagtatatat gtttcgaaat acaaatcttt
    82741 tgtaagtctt cttagaatag gatatattgt tccttcattt acatctatta ctttagagat
    82801 gttatgtact atctcatatc catacatatc tttcttagat atgagagcaa gtacacaaat
    82861 ttctaaaaca ccctttctaa attgtgtgtt catatactcc atcctttctt taaatacaca
    82921 gtattgtgtt ttacaaggta ctatgttaaa acttcttata tcctcataat aacacagtac
    82981 tatgttctgc acaatagtta tttttaaata ttcttgttga ttaaatcctt ctataaatgt
    83041 ataatactct aatcagatat attttatgaa agtggtgata aattggctaa aatgaaagat
    83101 gataaaacaa tattaatcct aactgctcaa tttggtgctg gacatataag tgctgcaaaa
    83161 gcagtcaaag aatgtattat tgaaaaatat agtaactata atgttgttat acaaaacttt
    83221 ataaatgcaa gtattcccat gatgaataag cctatggtaa aactttatga aaacaataca
    83281 aaatatactc ctggattata taattactat tattacttta agaaatcgtt tgattcaaga
    83341 catgatttat ctcataaatt atatacacct aaactttctg agtatattgc tgatataaat
    83401 ccagatttga ttatctctac atttccacta gctgctgctt gtgtaaataa ctttaagata
    83461 aaaaatcctg atataaatat acctacactt acagttataa cagatgttgt agatagtatg
    83521 gaatgggttt ttgaaaatac agatttgtat tttgttcctt ctcctgaaat aaaaaataga
    83581 ttttttcaga aaggaataaa tcctgactcc ataaaggtta ctggagttcc tgttgataag
    83641 agatttcaaa ttgaaagtaa agaactatgt tgtgataaat atagactatt acttctaggt
    83701 ggaggaagag gtctatttga tatagatgag gattttatgc attggataga tgaatttatt
    83761 gaagaacata gtaattctat agaaattaca atagttactg gtaaaaacaa aaaattatat
    83821 gacaatctaa ctcataaaaa acctctaaaa aatattaaag tacttggatt tgtaaacgac
    83881 atgtataatc taataagaga atgtgaccta atgctaacta agcctggagg agcaactata
    83941 tttgaagcta ttcaatcaca aactccagta ctcgtaaaaa tgccaaaagt tggacaagaa
    84001 attgaaaacg ctaaatttat aatagataag ggtcttggca tgatttatag tgatgaccta
    84061 gaccttaaaa acatatttta taaattagta tcaaatgaat ttgattctat aataaacttt
    84121 atgaaaaaaa atttaaaaga atttaaaaca gtcattcatc cagagaaaat tgctgattat
    84181 atatcagaat taatagataa tcattacagt taaattgtac tattaaaaaa tttcaaacat
    84241 aaaattaaag gcaatcaagt atgattttac acttgagaat ttactcatag tgtttaataa
    84301 tacttgattg cctttatcat atcaaaatca aattgttata ttagtatata tttttcttgt
    84361 actgcatata cagttgttgt atttcttcca tacttctctt taattctatt tgtaaatctg
    84421 aagcagtctg gtaatcctta ttttctatag cttctctcac tctagtgaat agtgattctc
    84481 tagttaaagt atccttcata atattgaact ttaaatccga tattgagttc caaactacct
    84541 catcaagcgc atccatattt tcttttgtgt gtatcttgac aatacttctt attttttgaa
    84601 tcccagcctc tattattcta gtttttaatt tcttttgcca cttatctata gctccaatct
    84661 taaatgattc tattatacta tcagtaaata catcaccttg ttttaaagat tttaattttg
    84721 aagcatatat ttctaagttt ttcatatttt cataaactgt agctggtggt attccaaatc
    84781 ttgcatttct ttcttccaaa ctataatgtt caaatacatc attttcatct ctatatgctc
    84841 tatctttttc taaatagaaa ctttcttcac ctacattttt agataactct ttttcaagtt
    84901 cttttgtact aagaccactc ttagctgctg cttttatacc atccaacatt gtttgataac
    84961 atcctgctat tactaaatac gtgttagata gagggcttgg tgaccttaat tcaaatctta
    85021 cagtctttgg atttttcata tctcttatta atccaacaag cactgaccta tttcttgatg
    85081 gaatctcata actatgccct aaagatgtaa ctatacatac aggagcttca aatccaggaa
    85141 ctaatctatt aaatccatca ttagaagctg ttacaattgg gtttaatact tcataattgt
    85201 aaagaagtcc cataagagcc ccatatccta gttcacttag ataatcttct tttaaatctt
    85261 ttggagcaaa tagatttttt atacttccat cctttaactt cgcacttact cctacatgtg
    85321 tatgtccacc acttcctgct actccatgaa ttggttttgc tttaaatgta acttctagtc
    85381 catgtgatgt aaatacatcc tctataacat ctcttactaa taattcattg tctgctgctt
    85441 gtaatggtgt agaaaacttc caagaaacct ctaattgctc catagcatgg tttgttcttc
    85501 catctatact aatagaactt tgtattcctc cgacctcttt gtgagccatt tcagggttta
    85561 cacctagctt ttgaagtata attaaacttt tctctaaaca agttcttata ataccatgag
    85621 ttcttttcca gtattgctct tttaggcttt gtgatacata taatttctct aagtcagctt
    85681 tatcctcagg agtattaacc cagaactcaa gttctgtagc tgctgttaac attatttcct
    85741 ctatatcatc tactgaatct attcctatgt tatttattac atgtggatat tctctaaata
    85801 tttcatacat tgacttttta aagtacttat ctgctttttg aagtactcct ctagaacata
    85861 cttttttatt atcatgtatt aaaaatgcag gtatctttaa tgttccaaca ggtagaccta
    85921 cttcttcgtc tatatattcc atattgtaat ctacatacca atgacaactt ttatctggca
    85981 ttaaatctac tttcgcatta tttaatgtag ctatattata aagctcaaca cttgaaccat
    86041 cagtctgtat agctgattcc aaaaatttat ctatatcctc caaaaataat tctacaggaa
    86101 tcttttcatc tgttgcattt cctcctaaat caacccccat taaggaaaca aatcttatat
    86161 ttttattgct ttttaggatt tctcttaatt cttcattagt gtgtttatct ttctctatta
    86221 cgtataatag actatccatt tttccactct cccataattt ttatgtatat tttattttgt
    86281 taaatacaag ataaatttca ttttccttac atttatgaat ttttcttgca aattattcgt
    86341 gttttattcg tgtttttatt tatattatta tatatcaagt ataaaaagtt cgcaatattt
    86401 tttattggaa aaaatattat acatacaata gtttaacatt tttacaaata tggggtatac
    86461 taaaataaaa gtatttttat ttgaaaattt aattttattt ataatataat ctatagtaaa
    86521 agaaataata aaaaaattta ggagataaac tttatggaat acataatttt cgatttggaa
    86581 tttaaccaag gatttgataa aaaactcaat aaaactgtat ccaatgaaaa gtgtcctttt
    86641 gaaattatac aaataggagc aattaaattg gattctaaat tcaatataat agatacgttt
    86701 aatagttatg taaaacctac aatttataaa gacatacatc cctttattag tcgtatgact
    86761 aatattaaaa attctgattt taatgattcg cctactttcc ctgaggtcta caacaatttt
    86821 ataaaattta tatcatcaca agaccctata ttatgtgttt ggggagctgg agatttaaag
    86881 gaattataca ggaatatcaa ctatcacaag ctaccatcaa attccttacc taaatcttat
    86941 attaatatac aacaacatgc atctaaatat ttcaataatc cagcaggaaa aagcattggc
    87001 ctacaaaatg ctatttctat attagaactt gatgaaaaaa tgtcttatca caatgcttta
    87061 aatgatgcat attatactgc taaagttttt attaagatat acaatccaag tatagtccca
    87121 gatatatatc tttatacaag tataaaacct aaaactataa gatattctaa caaaaaaaga
    87181 gttgattatg ataagttatt tgatgaattt aggaaaattt taaatcgtga attaactaaa
    87241 gacgagaaaa aaatcattaa cttagcttat aatatgggga aaacaaatca atttacatta
    87301 gaaaatgtta agcaaagaaa aaacaaatag agtttattta gataaaaaat aggcatgtag
    87361 attaaaaaac tagttaactt taaatttata tctacagccc aatttttatc ataattaatt
    87421 tttattttat ctctaattca actggacaat ggtctgaacc taatatttca gtgtgtatat
    87481 ccgcacttac taatctatct tctaattttt tggatgcaca aaaataatct attctccacc
    87541 ctgcattatt ttttcttgca ttaaatctat atgaccacca actataaaca ccttctttat
    87601 caggattaaa atatctatat gtgtctataa acccactgtc taataattta gaaaacttct
    87661 ctctttcttc tttagtaaaa cctgcatttt tcatattatt tttaggattt tttaaatcta
    87721 tttctttatg tgcaacgttc atatctccac acacaattac aggcttatga ttatctagtt
    87781 tggttaaata atctataaag tcgtcttccc atctagttct atattctagt ctctttaatt
    87841 cagattgaga atttggcgta tatactgtaa caaagtaaaa atcttcaaac tctagagtta
    87901 tcactctacc ctctttgtca tgttcttcta tatttattcc atacattact tttaaaggct
    87961 ctttttttgt aaatatagca gtacctgaat aaccctttct ctcagcataa ttccaatatt
    88021 gaaaatatcc tggtaaatct aactctattt gcccttcttg caatttagtt tcttgtaaac
    88081 aaaatatatc tgcatctact tctttgaaaa agtctaaaaa tcctttccca acacaagctc
    88141 ttattccatt aacattccat gatataaatt tcatacttat actcctcatc taaacattga
    88201 cacactcccc atagctaaag atgggggctt ttcaacaatt ttattgtaaa ttcttaattc
    88261 acttttattt taacaatgct atactataat ttcatctaaa attactattt acttaatacc
    88321 taaaaatata tgttttaatc aatttttaac ttttttgtta aatcttcagg gctcattgaa
    88381 gaaacataca tatttgttcc aagttcaaat cctccaaaat tatattttct tgggattatg
    88441 tgcatatgaa cattaaaata cgattttgtt tcaatctttg ttggatgagt gtgaatacat
    88501 aaattaaatg gcatatatcc attgatatta tataacttct taaacaactt ttcaaatatt
    88561 gtagaaagct cctgtatatt attatcattt aactcaccaa actctatttt atctttaaat
    88621 attattctta cttctccact atacttggtt gcatatggta taagtaccaa aaaagcttct
    88681 ccattataaa caactcttct atctaaactt atttcatttt ctattaaatc atcatacaaa
    88741 gagcttttat tgctgtcata atactccttt gaaaccaaca gttcattcgt aatttcaggt
    88801 ggaataaaag acatagacaa tatttgagca tgtggatgca tcaaagatgc tcctgccttt
    88861 ctcaagaagt ttttgaagat actaacatac tctactttat catctttcga caaatctcta
    88921 aatctatttc tatacataaa aaaaacatct tcaaattctt tttgactcat gttataaaaa
    88981 ctacgattat gtttatcgct ctctatcatt acttcatgaa caccatatac atctcttgcc
    89041 atatcatcaa ttataggaaa tttattgtag acagatttta caagccatcc ttcttcactt
    89101 tctatttcaa ataatgcatc agttgcatga gcttcatttc ctttgcaaaa tgggcattct
    89161 tcatcatatt cattagtttc ttcatcttca tttgggatat ctgctgtatc taaaggtctt
    89221 tttaacctat ctgtagcaaa tataacaaca tcattggtaa ttggatctat tcttaattct
    89281 ttcataatta acacctctta gttaatagcc tttaatataa ttatatgata tttatcgtat
    89341 ctgttaaata aatttataat attttttata attttgcata tttattatta tatattttgt
    89401 ctatagctga aagattataa ctaaaaaatc actatcagta tatcagaata ttatcttact
    89461 ataaattaat ttatgaatac ataatttagt ggcataaaca tgggtatttt actataattt
    89521 gttaaaagtt tattttaaag ctatattaat tttttttgat gatttttacc cataagtatg
    89581 ttattattat cttgtaaaga tgtcttgtat tcaaacatac aatttacata atacaatata
    89641 cgtatttaaa ttaaataggg ggtattaaaa tgaattattc aaacagagtt agtgcaatgc
    89701 aagcctctcc aatcagaaaa cttgttccat ttgcacaagc agcaaaagat aaaggaatca
    89761 aagtatatca cttaaacata ggacaaccag acataaaaac tcctaaagga ttttttgatg
    89821 ctgttaaaaa ctttgatagc gaagtcttag aatatgctac atcagaaggt attccagaat
    89881 tattagaagc acttcaaaat tactataaaa cttacgatat gaattttgaa aaagatgaat
    89941 tattagtaac taatggtggt agtgaagctt tacttttcac tatgatggca gtttgtgacc
    90001 caggagataa tctattagtt ccagaaccat tctatacaaa ctacaatgga tttggtcaat
    90061 ctgtaaacgt agaagttaat gctgttacaa caaaggcaga aaacggtttc caccttccat
    90121 ctaaagaaga aatattgtct aaagtagatg ataaaactaa ggctataatt ctttctaacc
    90181 caggaaatcc aactggtgca atttatacaa aagaagaact taatatccta gctgaaatag
    90241 ctaaagaaaa agatttatgg ataatagcag atgaagttta tagagaattt gtttatgatg
    90301 ggcttgagta tacaagctgt ggtaacttag agggtgtaca ggatagagtt ataataatag
    90361 acagtgtttc taagagatac agtgcttgtg gtgctagaat tggttctatc gcttgcaaaa
    90421 ataaaggtct tatcgctcaa atccttaaat tatgtcaagg aagactttgt gttcctacat
    90481 tagagcaaat aggagctgtt gagttataca aaactcctgt ttcttacttc aaagaagtta
    90541 atgaagagta caaaaaaaga agagatgtat tatacaatga attaatgaag gttgaaggtg
    90601 ttatatgtaa aaaaccaact ggtgctttct atatagttgc taaattacca gttgaaaatg
    90661 cagaagattt cacaatttgg atgttaaaag aatttaacaa agataatgaa acagttatgg
    90721 tttgccctgc tgaaggattc tatgctactc caggtttagg acgtgatgaa ataagattag
    90781 cttacatctt aaatgaaaaa gaccttcata gagctgctac attattaaaa gaaggtttag
    90841 agcaatatgt agctttacaa aaataatttt ttaaacttaa tttatataaa tttaatgata
    90901 taaaatgtcc ccttttcaga tattatttga aaaggggaca tttcttaatt aatatattaa
    90961 ttaagactta gacctgacta tttttcattt tctttatata gtgttggcca gtaatcttta
    91021 ttcactttaa ttaaagcatc taaaacttgt cttgccttag ttggagagat tatagttcta
    91081 tttaatgtta aagataaaat agctttttca taagattgtt caaagtatgc atcaactgct
    91141 aacttttcat aagctagttg accttctaac agtcccttat aaaatgttgg tatattacct
    91201 acatgtaaag gtctcggtcc attctttgta agaatcgcag ctacttctac cattgcatca
    91261 tcaggtaagt tgctaatagc cccattattt tctgttataa ctatggctat ttggtgtttg
    91321 ttatgagcta ttgcttctgc aacttcaact ataaattccc catgagcatc attatgcact
    91381 aaattagaac ctatagatgt tcctttttct ataacagatt tacattcttc aaatacacgc
    91441 ttttctcttc cattcataac ttctcttgct ctagtacaat ttatatttga tttagctact
    91501 tttttatcag gatatagata atactgtaca tatgtattag gtaagtaatc tggtacatct
    91561 tccaacatat ctttaaccat tccataagtg tctaaccaag atttatctct ttgttctgca
    91621 tcaacaggtt ggaatccaga gtttgctact aaatctttta tcttaggtac caaatcttca
    91681 ccatttttat catacaaatg tgtaaaccat ccaaagtgat ttaatccaaa gtatacaggc
    91741 tcaaatgttc ttgaatccat gtctaacaat cttccataag accttaacaa gttaactggt
    91801 tggtcacaca tattaagtaa tcttttatca tctggaaata ctctttttaa tgcttctgca
    91861 acaatagcag caggatttgt ataatttaat atccatgctt taggagagta ttttcttaca
    91921 gtcttaacca tttctatcat atcacctata gaccttaacc cataagcaaa tccaccagct
    91981 ccacaagttt cttgaccaac cagtccaaat tgtagaggaa tcttttcatc taattctcgc
    92041 atcttaagac caccagttct catttgaaca aatacaaaat ctacatctat aaatgcttca
    92101 tctgggtttg tagtatattc aagtgttgct ttaggatatt cttctttaaa taatattttt
    92161 ccaaattccc ctattaatct ttgacgttct tctactacat ctaacatagt tactttattt
    92221 agaggaaatc tatcactcat tttacataaa gactttaaaa gtcctggagt ccaagtactg
    92281 cctcctccaa ctatagctat attgtatctt tttttcattg tcatattaat cacccctgtt
    92341 ttttattaac taacttgtaa gatgattata atatataaag ttttctacat gaatactttt
    92401 aggtaatcat taaaaatagt tcaattttag tatttttttc aaaattgtaa tttttttcat
    92461 ctattgtatt tttcaatgta tttatgaaac atatattcca taagagaaag tgctggcact
    92521 ctagatgtat agttaacact attaaaatta tattgtggag aagatacaaa taattttata
    92581 tcagctatat ttgataatga attgacactt atatttgtca gagaaattac tttaacttga
    92641 tttgtttttg ctatattaca tgccttaata acttgagcag tctctccaga catagataca
    92701 gcaattacaa ggtcatcttt agtaatattt gatgcagcca aatacatgag agttgaatca
    92761 tcatagtatt ttacatttac acctatagct gaaaaacgtt gagacatttc agtacatact
    92821 aatctagaag acccaacacc aaaaaaatat atatgcttag aattatgtat ttcatttaaa
    92881 cacatatcta tattctctac atttattaaa ttttgtgtat ccataacatc agtaaaaata
    92941 tcactttgac ttttagtaaa ctccttattt ctttcatttc tatttgaata tgaaaaaact
    93001 aaaaagtttt taaattcact atatccagaa aagccgagct tctgacaaaa ccttactatg
    93061 tatgcagtcg aattaaaagt ttcatttgct atatctttaa tctttttttg atttattttt
    93121 tcagaatttt ttagaaaata gtttaaaaga gatatttcat ttgtagataa ttttttttga
    93181 tttatatcta atttgtctat taggttcatt tatacctcca taataatgat ttgtagttaa
    93241 acaactttct catatttatt atataaatat acactataca gcatttatct tatgtttatt
    93301 atactataaa aaagacaata caaattataa attagtattg ccttttaata tttactttaa
    93361 atagacattg caaaagaaac ttcgtctctt acttgagata cagatggccc ataaattatt
    93421 tggatatctt tatcagatac ttttataact cccattgcac ctgtatattt tttaaaagca
    93481 ttttcatcta ctttactcat atctttaact actactctta agcgagttat acagtttgtt
    93541 atatcttcta tattgtcctt accacctaaa tatttaatta tagataatgc tctcttagta
    93601 gtttctccac tttgagctat ttctacttta tttgataaag gttttaaatc aaaatttata
    93661 tctgttattt cttctcgtcc tggagtttgt aagttaaatc taagtatcaa aatcttaaat
    93721 acattataat aaactattgc atacactaaa ccaagtatta tagaataaat ccactttgta
    93781 tttggttgca taactccaaa tactactaaa tctattatgc caccttgagt atttcctatt
    93841 gctactccaa atatatgcat catcataaat gatatacctg ataaaaatgc atgtataaca
    93901 aataatattg gtgatacaaa taagaatgaa aattccaatg gttccgtaat tcctgttaca
    93961 aatgttgcta aagcaccagc tagtaatata cctttaacct tcgacctatt ttcaggcttt
    94021 gcagttttat acatggcata tgcagcagca ggaagaccaa ataccattat aggtattttc
    94081 ccttgagcta aaaatctagt tgcttctgtt gaaaaactga ttgtttcagg gtcacttagt
    94141 tgagctaaga atatgttcaa tgctccaaat acttcttgcc ctcccacaac taaagaacct
    94201 cctacttcag taaatctaaa catagcattt aatatatgat gtaatccaaa tggtattaaa
    94261 agtctttcaa gaaatccaaa tacaaatgtt cctaaatatc ctaaactagc tataccaata
    94321 cctacactct gaataattgt atttacatat ggccatatat atggtattat tatccccaaa
    94381 atagagaata ctactgttgt tattattgga acaaacctag ttccaccaaa gaatcctaaa
    94441 taatctggca gttttatatt atagtattta ttatgtaatg atgctgttat tataccaact
    94501 acaattccac caaatactcc taattctaat gtttgtatgc ctaaagttac agcttgaccc
    94561 atttctctca tcatgtcagg ttcagcaata atccccctac accctaacat ataatttaca
    94621 ctagtgtgta atactaaata accaacaaaa ccagaaaatg cagaaactgc tttttcttct
    94681 ttagcaagac caacagatat tgatatagca aagaatattg ctaagtttcc aaaaagtact
    94741 cctgttatag cttttgtaaa acccaatatt ccttgaataa aattatttgc taaaaaaggc
    94801 atatcactaa ctatattagg atttgaaaat gctgaactta ttcctaaaaa tatacctgct
    94861 gcagatatta atgctattgg caataaaaat gattttccta actgtaaaaa gaaccctttc
    94921 attttttgtt tcatttctat ccctccattt ttaaattttt aaaacgtttt ctatgtcata
    94981 attatatatt tttattttgt ttttgaaact ttataatttg ttttaaaata tttttacata
    95041 aatagtaatt ttttcaaaac tgtaaatttt ttcaaacaaa gacatagtaa cgttgtaaca
    95101 tatataaatt taaaaagagc ttagaaaata aaattattga atataaaatg gaaaaatata
    95161 aattacacaa agagatatga gtacgtacta acaaatacga aaatgtataa gaaattataa
    95221 aaaagtacat caagaaaatt taagatgtac tttttagatt gtatttagac ttataatt
//
LOCUS       DAEPID010000006        83950 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.006, whole genome shotgun sequence.
ACCESSION   DAEPID010000006 DAEPID010000000
VERSION     DAEPID010000006.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 83950)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 83950)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..83950
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.006"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            complement(269..1423)
                     /locus_tag="KR257_000464"
     CDS             complement(269..1423)
                     /locus_tag="KR257_000464"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003427194.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MFS transporter"
                     /protein_id="HBH0029191.1"
                     /translation="MINKAIKFKFIIFYFFSYIIFAFASTKFTPFLSKLGYSAFERGI
                     ILSSYAITNILFQLLFGVLADKYQTMKKIVLISLSVYGIASVIMFSTESATFIIYLLL
                     VALSGGLLNTCCSLYDTWIIGCGDNINNYLSFIKTFGSIGWAIGSMVASYLILRFSYF
                     GLSVAIGLIVVLLIINILLLPDIEKINKKINVTNKDIIELLKDKKYILLVCILFLLYS
                     MVVANNCTVIDKMIALNATNSQISLKWSLQSLLEIPTYLAGSYLLKKYSSLNLLKLSA
                     IMITVQFLLFALTNDSNIIIILCVFQVFSTPLILITSKRLIFEVSPKKLRSSSQLIAL
                     SIFMGGSSLIIPTVAGFLSINIGYNYTLMVLSLFGCLAYCLIVLLNYLQE"
     gene            complement(1426..1893)
                     /locus_tag="KR257_000465"
     CDS             complement(1426..1893)
                     /locus_tag="KR257_000465"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891369.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS glucose transporter subunit IIA"
                     /protein_id="HBH0029192.1"
                     /translation="MFFKRKKEAITINSYIDGKIINLGEIPDKVFSTKVMGDGFAMIA
                     KDNILKSPTKGVISFIAQTNHAIGIKLQNDVQILIHIGLDSATTKKENFKLEVKQGQE
                     VNMGEKLVEIDNKLLENTLYIPLVIVENPNTVKYHLSNLNQEGNSGIKVINFD"
     gene            complement(1907..2395)
                     /locus_tag="KR257_000466"
     CDS             complement(1907..2395)
                     /locus_tag="KR257_000466"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003431368.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0029193.1"
                     /translation="MITNKIKNITAVLKDENIFLSVVMVCFLILPVLYIVYLELTSLF
                     TNISFSQLLNNDVNASLNLISNFSAVYSAYVIYNIKKNKEIKENMIAFYLVLLGQIFQ
                     IYTITIVIMFTYIYKFVGIKQIISSIKELQWGKSYKALFSSIAVCLISLFVMIIRIKL
                     IM"
     gene            complement(2409..3740)
                     /locus_tag="KR257_000467"
     CDS             complement(2409..3740)
                     /locus_tag="KR257_000467"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891372.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="6-phospho-alpha-glucosidase"
                     /protein_id="HBH0029194.1"
                     /translation="MERKRQRILIAGGGSTYTAGIVTMLIESVAKFPIESIKLYDNND
                     ERQRKVAEACAIIVREKNPEIKFSYTTNPEEAFTDIDFVMAQIRVGLYALREQDEKIP
                     LKYGVVGQETCGAGGIAYGLRTIGPIIEMIDYMEKYSPNAWMLNYSNPAAIVAEACRV
                     LRPNSRIINICDMPVCLEEIFARVLGLNSRKDFDVRYYGLNHFGWWTSIKDKEGNDLM
                     PKLQEYCAKKGYEEFTPQGQHKESSWLETMRAAKDLLEIEPTTLPNTYLKYYLMADET
                     VEHANPNYTRANEIMDRREKDTFEECERIIKNGTARDTWFDASEHSQFIVELACALAF
                     NTQERFLLIVPNNGAIENFADDAMVEIPCLVGKDMVEPMSIGKIPTFQKGLMEQQVAS
                     EKLAVEAWIEKSYQKLWQSFTMSKTVPSAKVAKEILDEMIVANKDFWPTFK"
     gene            complement(3754..5319)
                     /locus_tag="KR257_000468"
     CDS             complement(3754..5319)
                     /locus_tag="KR257_000468"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003233606.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS transporter subunit EIIC"
                     /protein_id="HBH0029195.1"
                     /translation="MMKKIQRFGGAMFTPTLLFAFAGIMVGFSIVFQNQSIMGSLATP
                     ENIWYQFWGVISSGAWMVFNQLPLLFAISLPIALAKKQQARACMEALATYLTFNYFVG
                     SMLSFWGKSFGVDFAAEISAGSGLVSIAGIKTLDTGMVGALLISGIVIYIHNRFYDKE
                     LPDFIGLFRGSSLVVAICFFVMIPVALLTCFIWPHIQNVIRHLQTFFINSGNIGVWCY
                     AFLQKILIPTGLHHFVYAPICYDSVVVPGGTSVYWATHIQDFQTSAKTLKEMYPIGFS
                     LSGLSKVFGSLGVFGAFYVTAKPEKKKKVLGLMIPATLTAVLTGITEPLEFTFLFVAP
                     LLFLVHAFLDACLQTISFALGVVGDFGGGIINWVVLNWLPLGMYHWKVYVVQVVVGII
                     FSFIWFFVFTFLIKKFDMKTPGREEDSEETKLYTKNEYLETKDEKGNKLSKASQQASE
                     YIKLVGGAENVVDVTNCATRLRLTLKDDSIISKEEDFKAVGAHGLVHNGKAIQIIIGL
                     SVPSVREEFENLL"
     gene            complement(5489..6274)
                     /locus_tag="KR257_000469"
     CDS             complement(5489..6274)
                     /locus_tag="KR257_000469"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422510.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MurR/RpiR family transcriptional regulator"
                     /protein_id="HBH0029196.1"
                     /translation="MRLEEMIFLNYNKLNDTDLLIWKYITANKKHCSKMSINELAMKC
                     NVSRATITRFVKKLDLKGFSEFKVLLSWESEKVHVIENQSFDIACNSIIKYVEDQKNK
                     DYDALCKLLYESRTIYAYGSGDIQNVVAKQIKRMFLSCQEIIYDFEGRTFDDSFYNIV
                     SKNDVMIIISLSGENENTLNIARRLKLIGTKIISITEFKNNTLTDLSDESIYISATNI
                     SFLQMHPSYKLTMLYFILIELLFIKYSIYKRHRMITEGIDCKL"
     gene            complement(6441..7640)
                     /locus_tag="KR257_000470"
     CDS             complement(6441..7640)
                     /locus_tag="KR257_000470"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898126.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptidase S41"
                     /protein_id="HBH0029197.1"
                     /translation="MKKKVLFLVIILAFIILLGNSTYSQKNQLSEEEKVDDFNYVYNV
                     VKTGYPYLGVNKRLNNIDWLANKDEYTKRIKNTENDEEFIEEMSSILSDLNNKHTEVI
                     DNKKRYELFKKSYSNNDWYDFLNDKKVVDRYDSMNLKIKMPDDIFVKKELILKDVIKG
                     QIGYMYLPSMSSKNGSINNDLKIIGDYIDTLEKHKALIIDIRGNLGGSDSYWQGIVSK
                     LIKNDVKINGYRIYRNNNEIVKQYTNARNIKLNPVENLPTSVKENAPKEIIKDFNDFE
                     DTSYTIKSTDDSKFKGNIYLLVDRKIYSSSESFAMFCKETKFATLVGETTGGDGGCID
                     PVLFNLKNSGLIVRMASCMYLNKNGICDEEFKTIPEFKVKDCKRTADFKDDNCIRKAL
                     ELENINY"
     gene            complement(8162..9499)
                     /gene="xylA"
                     /locus_tag="KR257_000471"
     CDS             complement(8162..9499)
                     /gene="xylA"
                     /locus_tag="KR257_000471"
                     /EC_number="5.3.1.5"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891378.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="xylose isomerase"
                     /protein_id="HBH0029198.1"
                     /translation="MSEIFKGIGQIKFEGVKSDNELAFRYYNPEQVVGNKTMKEHLRF
                     AMSYWHTLCGEGNDPFGVGTVERPWNNITDPIEIAKIKVDAGFEFMSKMGIEYFCFHD
                     RDIAPEGRDLEETNKILDEIVEYIKVNMEKTGIKLLWGTANMFGNPRFVHGASTTCNA
                     DVYAYAAAQVKKAMEITKYLGGENFVFWGGREGYETLLNTNTELEMDNFARFLQMAVD
                     YAKEIGFTGQFLIEPKPKEPTKHQYDFDTATVLGFLRKYNLDKYFKMNIEANHATLAG
                     HTFQHELNIARINNVLGSIDANQGDLLLGWDTDQFPTNIYDATLAMYEVLKQGGIAPG
                     GFNFDSKVRRASFEVEDLFLAYIAGMDTFAKGLLIAHKLLEDEVFENFTKERYASFSE
                     GIGKDIVEGKVGFKELESYALQMPVIKNKSGRQEMLEAILNRYIYEVDTISNK"
     gene            complement(9595..11145)
                     /gene="xylB"
                     /locus_tag="KR257_000472"
     CDS             complement(9595..11145)
                     /gene="xylB"
                     /locus_tag="KR257_000472"
                     /EC_number="2.7.1.17"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012816371.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="xylulokinase"
                     /protein_id="HBH0029199.1"
                     /translation="MKLEYVLGVDIGTSGTKTVLFDKLGNTIKSCTYEYPLIQEKSGW
                     AEQDANDWWKAVVESIREVVQSSNISSECIKGIGLSGQMHGLVMLDNEGKTLRNSIIW
                     CDQRTVKECEEITDLVGEERLIEITANPALTGFTASKILWVRNNEPDIYKNTNKILLP
                     KDYIRYKLTGEYATEVSDASGMQLLDIRKRDWSDEVLEKLNIDKNLLGKVYESQEITG
                     YVTRDVASLTGLKEGTIVVGGAGDQAAGAIGNGIVKDGVVSSTIGTSGVVFAYTKEPK
                     IDKEGRVHTFCHAIPNTWHVMGVTQGAGLSLKWFKDNFCQSEVEVSNSLGEDVYEIIN
                     NQVSQVPTGCNGLLYLPYMMGERTPHLDPYARGVFFGLSPIHSKKEIARSIMEGVSYS
                     LKDCMDIIENLNIDVNEVRASGGGGKSKVWRQMQADMFNQDVYTINSSEGPALGVAIL
                     ALVGAGIYENIQKACDAIIKTSTKLEPISENVDTYNIYHRLYKRIYKSLKDDFKLLDE
                     VVNAKINN"
     gene            11353..12513
                     /locus_tag="KR257_000473"
     CDS             11353..12513
                     /locus_tag="KR257_000473"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903434.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ROK family transcriptional regulator"
                     /protein_id="HBH0029200.1"
                     /translation="MVTDKYTIREMNERLVLEQIIKNGPISRASIASTIGLNKATISA
                     ITKKLIDESLVHEIGIGNSTHSGGRKPILLVFNKCAGISLSMDIGYDYIFSSLSYLDG
                     TIINSKKLTDIQVSKDNVIQLIDEIINSYNISKIDTPYKVIGLTLAIHGITCENKVLF
                     TPYYNLNEIDLYSILSKKYDFPIHIENEANLTALAENTFSTVHNSLLSLSIHSGFGSG
                     IIINNKLYSGRNGMSGEIGHTIIMPNGKLCPCGNRGCLEQYCSEKKVFEQLSSLENIP
                     KIDSDIVKQLYYEDNHNAKKVIHEFCSYLTIAINNAITTYAPEIIYLNSQIISDIPEI
                     LQITKDMLVSSFNKGINIEISSLGSEASLYGGSAVNIKSFLNIQNLTLINEI"
     gene            complement(12669..13073)
                     /locus_tag="KR257_000474"
     CDS             complement(12669..13073)
                     /locus_tag="KR257_000474"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422503.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIA"
                     /protein_id="HBH0029201.1"
                     /translation="MNSIILMSHGNMAEEVLNSAKMIIGDSIDYPTVNMKQDDGIEGT
                     IEKLKKALEVYKESSEIIIMADLLGGTPCNAALLVANNDSRIKIISGLNLGMVIESAF
                     LDTKELAAKLEKIGKDNISMVEQNASLLSDDE"
     gene            complement(13094..13576)
                     /locus_tag="KR257_000475"
     CDS             complement(13094..13576)
                     /locus_tag="KR257_000475"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009906215.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIB"
                     /protein_id="HBH0029202.1"
                     /translation="MEMKGIKNIRIDDRLIHGQVATMWSNKLGVTRLMVVNDAVANNS
                     VQKQVLRMATPAGIASSIITEETAIKNITAGKYEGQNVLLIVKSPVDLIPFVEAGFKI
                     HNINVGNMSSRKDTTVLRPNISVTEEEKEAFKRLLDEGIEITTIMTPDDKKTYLVDIL
                     "
     gene            complement(13596..14405)
                     /locus_tag="KR257_000476"
     CDS             complement(13596..14405)
                     /locus_tag="KR257_000476"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003427216.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS system mannose/fructose/sorbose family
                     transporter subunit IID"
                     /protein_id="HBH0029203.1"
                     /translation="MSDKVSLNKSNEKVKKSVLWRWFFTSSVSSNYEKMQALAYCYAV
                     LPFLKVVYKDNPEKLQSAVLNHLQFFNTNPWVAPYILGINVAMEELSSEETEEAVASI
                     KTGLMGPVAGLGDSLFVVIPWTIFGAIAANMAIDGSPFGILLWIVVSVALKLLSIPLF
                     NAGYTSGTKLISSIEKSLKILTESTSILGLMVVGALIPSVVKANVALNFQQGDFTMKG
                     QEILDQIMPGLVPAILVVIVYWALKKNIKPIYLILGVMVVSIILYALGILK"
     gene            complement(14398..15177)
                     /locus_tag="KR257_000477"
     CDS             complement(14398..15177)
                     /locus_tag="KR257_000477"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422498.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIC"
                     /protein_id="HBH0029204.1"
                     /translation="MEPQLWQLLLIVLYGFFINYEKNSTMFGTYQPVTAGFITGLILG
                     DINTGLYIGGTLQLLSLGISNFGGASIPDYQTASIVATFITITTKQEASVGISIGIPV
                     ALLMVQLDVLRNTIGIWLVHKAEDGAKKGNYKNITYMQMLGVLLTAATTGIPVALSVI
                     FGPSLINTILKYTPEWLTGGLTVAGGLLPAVGIGLLLRYLPAKEYFSYLVIGFVLAVY
                     MKVPLLGVALIGGAIALIIYKKNLENQEQQYTVVGGMDEDE"
     gene            complement(15177..17255)
                     /locus_tag="KR257_000478"
     CDS             complement(15177..17255)
                     /locus_tag="KR257_000478"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422496.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyl hydrolase"
                     /protein_id="HBH0029205.1"
                     /translation="MIKISEDYIEKRFDNELLRIEAWGKNSLRIRSFVDQNFVDENYA
                     LNEKPKLNKDDITINKNEDGSAIIKNGKIKAVLDHRDRITFYNDKNEILLKEYIRLRA
                     VKHDDGGEDVGTIEITKDFNSTLKLKSREYRPSYSGEFEVTTRFESEPSEKIFGMGQY
                     QHKFLDLKNTVLELAQRNSQISVPFYISSLGYGLLWNNPGIGKVSFAKNMTEWKMFST
                     NFIDYWITCGESPKELNKNYSQVTGTVPMMPENLLGLWQSKLRYRTSEEVLDVVKEYS
                     KRGIKLSSIAIDYFHWPKQGEYKFDLDYWKNPKELVKKLKEEYSVEPIVSVWPTVQSD
                     AENYNDYLENGYLVNVNRGVRMTMQIQGNTVFVDMTNENAREYVWDRIDKNYKQLGID
                     YYWLDVAEPGYSVYDFDNYRYKKGNVLSCGNIYPIDYLKMIYDGLHNDIESVVTLVRG
                     AWAGAQKYGALVWSGDIDSSFEAFNNQVNTGLNMGLAGIPWWTTDIGGFHGGNPKDPE
                     FRELMVRWFQYATFSPILRMHGDRLPHSKPLSNKGGGSMVTGAPNEIWSYGEEVEVIL
                     TKFIKIRESLKTYLKKLMKEAHEDGTPVMRTLFYEFPEDDKTWEVDNTYMLGDEILVA
                     PIMNYKDRSRKVYLPKGHTWENIFSGVSYEGGKTYEVECPLEEIPIFLKQDSSYNFKE
                     LKNILGEVKS"
     gene            complement(18054..18575)
                     /locus_tag="KR257_000479"
     CDS             complement(18054..18575)
                     /locus_tag="KR257_000479"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861802.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF523 domain-containing protein"
                     /protein_id="HBH0029206.1"
                     /translation="MKRNREIVVVCHCILNCNSKVEGLSEFKGAQNIAIDLINKGYGI
                     IQLPCPEMIMYGINRWGHVKEQFDNLFFREQCRQMLIPHVRQFDEYLKNDYDIKSIIA
                     IDGSPSCGYNKTCSSKRWFGELSGCNELMDKINDIQMVDGKGIFIEELEKLLKEYNLN
                     IPIVGFDELREDK"
     gene            18741..19307
                     /locus_tag="KR257_000480"
     CDS             18741..19307
                     /locus_tag="KR257_000480"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898142.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ECF transporter S component"
                     /protein_id="HBH0029207.1"
                     /translation="MDTKKVTFSSMCIVINIVLGMVISMINIPLLFLDTIGTVLGAVV
                     LGPFWSALIGGCTNLVLGVISGPTNIPFALVNIVLGLIVGYISKKKGFGYKEAIITGV
                     ILSIVCPLIGTPISVLLFGGLSGSGADLLVGFLVQSGQKIFTAAFFPRILSNIVDKPL
                     SCIMVVYFISKMPKGFIKQYSKNTSSSY"
     gene            complement(19524..21587)
                     /locus_tag="KR257_000481"
     CDS             complement(19524..21587)
                     /locus_tag="KR257_000481"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003439939.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF262 domain-containing protein"
                     /protein_id="HBH0029208.1"
                     /translation="MKAGEIEFLSYLEGSNKSFVVPVYQRNYNWKKEQCKRLFDDLED
                     IIDSGFRTHFLGSVVSIYSMGKEYLIIDGQQRVTTVSILLIAMCQIIKEFGESKGIIT
                     TEEQIKECYLINKHSRDKDGKIKLKPIAEDRKAYYELFEEEMNTDRNSNIVSNYLYFY
                     NRIKEDNISIDDLFDAIQKLTIVEIELKNGEDDPQLIFESLNSTGLDLSEADRVRNFV
                     LMGRSSKLQEEFYNNYWYKIEKNTSSNVSSFIRDYLTIKERSIPNKNKVYFSFKRYVS
                     DNGIDIEILLKDLLKFSNYYREISYSCTDDNDVNKVLKRINKLEIFVSYPFILELFDD
                     YNEGIINKKVLVESLNLVECFILRRIVCDVPPNALNKVFMNLGREIKKFSDYKENYSN
                     ILRYIFINKKSSQRFPTDSEFSNAFETKDIYNTKSKNKLYILERLENYNNKEIVDLEN
                     LINNNMLNIEHIMPQTLTNKWKESLGDNYKEIHDKYLHTIGNLTLTGYNSKLSNKTFE
                     EKKEMEDGFKDSRLYLNKYISSIDKWNEEEIKNRTKILLDRAVEIWKYPSVTYEPPSN
                     SENIFTLEDDDVNFTNESIVSFSILGESYKAKNWTEFYEQVALTLYDLDSVRFNSIVD
                     KTYKRDFIDNIKSRDAYKLRKGIKISENIYLETNLNTEAKLNIIRFLLNEFDIELNEV
                     IFSIK"
     gene            complement(21968..25303)
                     /locus_tag="KR257_000482"
     CDS             complement(21968..25303)
                     /locus_tag="KR257_000482"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003439941.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DEAD/DEAH box helicase family protein"
                     /protein_id="HBH0029209.1"
                     /translation="MGNFDFLQKKKNFNSFNTACLEAEKSILVSPSTCATITRRALEL
                     AVKWLYANDSDLVLPYQDNLSTLIHNNSFIELIDYDMLPLLKYIVKLGNLSVHTSANI
                     ERGEAILSLNNLHQFVSWIDYCYSDEYTAEDFNEDLLLHGEEKRTRPDELKNLYERLS
                     SKDKKLEEVIKENEELRKSLTEKRKVNTVNYDFKIDEVSEFETRKRYINIELKLAGWE
                     FGKDIWEEIEVQGMPNESGVGYVDYVLYGENGKPLAVVEAKRTSKDPKIGQQQAKLYA
                     DCLEKRYSQRPVIFLTNGFDMYIWDDYSDRKVYGFYKKSELQLMIDRRKSKKSLSSVT
                     INDEISNRYYQKEAIRAVCEALENKQRKTLLVCATGTGKTRIAISIVDVLSRHNWIKN
                     ILFLADRKALVKQAKKSFTKLLPNLALCNLLDSKDSPEDARMIFSTYPTMMNAIDDTK
                     SKDGKRLFTPGHFDLIIIDESHRSIYKKYKSIFDYFDSYLMGLTATPKDEIDKNTYSV
                     FDMENGVPTYAYEYNKAVEDGYLVDYTSIEFKTKIMEDGIKYDELSDEEKEEYENTFN
                     DDESIGDEIGNNAVNEWLFNSDTIDLVLNKLMTEGLKIEGEEKIGKTIIFAKNTKHAR
                     AIVERFNKLYPKYGGNFVKAVDYSINYVDSIIDDFSDKNKLPQIAVSVDMLDTGIDIP
                     EILNLVFFKKVRSKTKFWQMIGRGTRLCPDLLGVDMDKERFLIFDFCNNFEFFKFNPK
                     GFEGNKTETLTEKLFNIKVSMVKELQDIKYIEGEYAELRKELLEELITSVKALNEDSY
                     IVRMNLSYVHKYKNENVWSNIGAVAQNEIREYISPLITSYSDDELAKRFDVVMYNIQL
                     AYLQNNNASKGIRHVMATAEKLSKLGTIPQIQQQKYTIEKAMTEDFWEDSDIFEVEEV
                     RISLRELIKYLEKSSQKIYYTSFEDMIVAEDRNDSVYNANNLKNYKKKVEYYLNSHKD
                     ELAIFKLRNNKKITKQDVETLEEILLKQLGNCDDYKKEFGDTPVSQLVRRLVGLDREA
                     ANEAFSEFLNNKSFNTKQIHFVKLIVDYVVKNGFIEDNKVLMEDPFRTVGSIIDLFEN
                     HIEERNKLIKTINKIKENASEIG"
     gene            complement(25353..25781)
                     /locus_tag="KR257_000483"
     CDS             complement(25353..25781)
                     /locus_tag="KR257_000483"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003427232.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0029210.1"
                     /translation="MVIRNKLSWNSIEEVNRDFGSCLYDLQNFKILYDKEEMPELWAR
                     YIKEGFKSYMVSFLELTKAMLYYKSIDLNIKSKNFYDYLLACEYHNLLPKNSSIVIET
                     LRKLRNDDSHGYDIPQFEDMYELFTENEEVFVSIRNSCKK"
     gene            complement(25771..26151)
                     /locus_tag="KR257_000484"
     CDS             complement(25771..26151)
                     /locus_tag="KR257_000484"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003439944.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nucleotidyltransferase domain-containing
                     protein"
                     /protein_id="HBH0029211.1"
                     /translation="MRNIPNEIKNSIINVFPKENTLAIIIFGSYGTDKHTSESDIDIA
                     WIPIKKVPITELATKTEALRNILDIDVDLKIVTDNYTIALKKAILEGEVIYKSKDFKD
                     YINKFYFENSDVIDILDWRDMYGN"
     gene            complement(26184..26492)
                     /locus_tag="KR257_000485"
     CDS             complement(26184..26492)
                     /locus_tag="KR257_000485"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903439.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0029212.1"
                     /translation="MNQIELDLYHNMVNIYKEADLQCNYKPTRFLQLINNKGALLAAK
                     ELINKEGATEGFTRLWECKRLDLSLEVLVLKEKYKELFTDEEREICINRLKDYGYKFN
                     "
     gene            complement(26537..27697)
                     /locus_tag="KR257_000486"
     CDS             complement(26537..27697)
                     /locus_tag="KR257_000486"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003427237.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="restriction endonuclease subunit S"
                     /protein_id="HBH0029213.1"
                     /translation="MEYRLNEVFEFIRNGASIKQFDTKFGYPITRIETIANSYIDTNK
                     MGYADIKELGKLEDYLLKNGDILMSHINSEKHLGKSAIYEDINKKIIHGMNLLCLRPD
                     KEVCYPKYLNYFFNSNEFRRQLPRIIKKSVNQASFSVNDLKNLKVDLPEMEAQKDISK
                     VLDKAQELIDKRKEQIEALDELVKSRFIEMFGNFKEQKFVLLKDCTNFIDYRGKTPIL
                     SENGIRIINAKSVGNGVFKYINEYISENTYNSWMKRGFPVAGDVLFVTEGHTFGNVCR
                     IPKDLKKFAMGQRIITIQGDKKILNNAFLAQYMQTKAFRVEIDKYKTGSSAQGIRSKE
                     LQKILIPVPSIELQNKFEEFVNQVDKLKVGIKTSLKELEDNFNSLMQKAFKG"
     gene            complement(27701..29164)
                     /locus_tag="KR257_000487"
     CDS             complement(27701..29164)
                     /locus_tag="KR257_000487"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891388.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SAM-dependent DNA methyltransferase"
                     /protein_id="HBH0029214.1"
                     /translation="MITGELRSKVDKIWETFWTGGLTNPLEVIEQFTYLLFIKGLDEV
                     ETKNEAEATLLGVSFEKIFDDEHQHLRWSKFSNEGNSEKMYEIVQNEVFPFIKKLHGN
                     KESAYAKYMGDAIFKIPTPLMLSKIVDGISNLELSKDRDTKGDLYEYLLSKVATAGTN
                     GQFRTPRHIIDMIVRLIKPTPEDIIVDPAAGSAGFLVSSQQYLRDNHSSLFLVQGLKE
                     HFNNGMFYGFDMDRTMLRIGAMNMMLHGVDNPNIEYKDSLSEVNTDKDKFTLVLANPP
                     FKGSLDYEAVSADLLKVTKTKKTELLFLALFLRVLKIGGRCACIVPDGVLFGSTGGHK
                     SIRKEIVDNHKLEAIISMPSGVFKPYAGVSTAIMIFTKTGTGGTDKVWFYDMKADGYS
                     LDDKRNEIKDSDIEDIIKRFDNLDGEVDRKRTEQSFFVDVEEIRENGYDLSINKYKEV
                     VYEEVVYDAPSVIIGRVRELEKEIVDGLEELERMLEV"
     gene            complement(29673..30542)
                     /gene="gatY"
                     /locus_tag="KR257_000488"
     CDS             complement(29673..30542)
                     /gene="gatY"
                     /locus_tag="KR257_000488"
                     /EC_number="4.1.2.40"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003439953.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tagatose-bisphosphate aldolase subunit GatY"
                     /protein_id="HBH0029215.1"
                     /translation="MALVTTKQILLDAQEGHYAVGAFNVENMEMVMAVIEAAEELKSP
                     VILQTTPSTIKYAGLDYYLANVKVASEKASVPVAMHLDHGSSFGLAMQALRVGYTSIM
                     IDGSHESYEDNISISKSVVDACMPSDIPVEAELGKVGGKEDDLDGGDGGAYTDPLEAK
                     EFVERTGVSSLAVAIGTAHGLYKGEPKLDLDRLSEIREVVSVPLVLHGGSGIPDEVIK
                     ESIKRGICKVNYATELRIAYSNGVKDVLNSDPEVIDPKKYGKKGLESVKDFVKSRMEV
                     CGCVGKAIEIVKC"
     gene            complement(30562..32478)
                     /locus_tag="KR257_000489"
     CDS             complement(30562..32478)
                     /locus_tag="KR257_000489"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003439955.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS fructose transporter subunit IIABC"
                     /protein_id="HBH0029216.1"
                     /translation="MGKKMILGVTGCPTGIAHTFMAEEALKNSARELGCDIKVETNGA
                     IGVENKLTAKDIEMADAIIVACDKNVDMDRFNGKPVIEVPVKEGIHKANELIQRCIDG
                     KVAIRKGNLSSSKIAEEGNLSFGQKLYKDLMNGVSHMLPLVVAGGVLTAISFLWGIYS
                     FDPNSEQYNQIAATLKSVGGYSMNLMVPVLAAFIAQSISGRAGMLAGLVGGMISFDTG
                     SGFLGGIISGFLAGYLVKLFVHLLRKLPRQLEGLKSIFIIPIVSVGLVGVAMLLLGGP
                     CSALNNAMMNFLSGLQNSSPIILGIVIGCMSAFDMGGPVNKAAYVTGTMLLGQGNYLF
                     MAGVSAACITPPLVIAIASTLFKNRFTEEDRAAGLINYILGSTHITEGAIPFAAKNPL
                     KVLPVLMIASSISSILTYIMKIEVPAPHGGFLVLGLVNKPLLWVGCIFVGSLVGAVLY
                     MMVTPKVVNEKNTIENTNVTKDEHKNESAESENVSNNISLYSEETVILDVKGKNKTDV
                     IDEMIGILDKSSVLLDKKKFKEEILKREEISSTGFGMGIAIPHAKTDAVKVPRVAVGL
                     SKEGFDFESEDGSLAHIIFMIAATDNGDNLHLKTLSQLSSKLMNEEFLNELLNSKTSR
                     EIVSKLNNEEIKSV"
     gene            complement(32481..33401)
                     /locus_tag="KR257_000490"
     CDS             complement(32481..33401)
                     /locus_tag="KR257_000490"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009906218.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="1-phosphofructokinase family hexose kinase"
                     /protein_id="HBH0029217.1"
                     /translation="MIYTLTTNPAIDMNISTNGIKRKLVNRTSNAVYSPNGKGLNVTF
                     VLGHYGIESKILGFFGGFSGKYIVEESEKRGFDVLPTWVEDTTRINIFLNDGSDEFKF
                     VNSGSYVNEKQKLDMLDKIQSLEDISYLSISGSLPPGIDDNYYEDIFKICENKSIKTI
                     LDISSPKLKELLQYNPYLIKPNDEEIKDIFGIIVRDEEDIKDVLKLLHLKGAQNILLT
                     LGEKGSYFYNGKSIYYASAQPVTVVSSACAGDSALAAFLSIWLENPEHIEEALKRSAA
                     TGASVAESNGIGNLENVEDYIKNIRVRKVV"
     gene            complement(33503..34255)
                     /locus_tag="KR257_000491"
     CDS             complement(33503..34255)
                     /locus_tag="KR257_000491"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003427244.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MurR/RpiR family transcriptional regulator"
                     /protein_id="HBH0029218.1"
                     /translation="MIIELNKSNSENLTKTELEIIKFINENESILPELSIVEIAHETY
                     SSPATVSRAIRKCGLNGFNELRYRLTVKDENDDIQNMGDIINKSFIEAQRVIEQISLT
                     TLINIIKTVNKSSKIYILARGLTEYVAKEFSLKLQLLDFNVVFINDPNIMKIKSKSIK
                     KDELIIIFSLNGNTIELVESAQNANLVGAKVITCCCSESAKLIKYSDLYIVGYKHEHI
                     SISEYEVSSRLPLYIISRIIIDYMVRYNNSEN"
     gene            complement(34647..36092)
                     /locus_tag="KR257_000492"
     CDS             complement(34647..36092)
                     /locus_tag="KR257_000492"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003427245.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycoside hydrolase family 1 protein"
                     /protein_id="HBH0029219.1"
                     /translation="MIKLGKFPKGFLWGGAVAANQLEGAWNEGGKGWCLADVHMYDKD
                     RDISKPYESDMTIERIKFAMKDNNGYYPKRSGIDFYHTYKEDLKLLKELGLKCFRFSI
                     NWARIFPNGDDLEPNEEGLKFYDNLINEVIDNGMEPIVTLLHYETPLNLVLKYKGWSN
                     RKVVDFFVRYAELILNRYKNKVKYWIVINQINLIHYESFNSVAFCVDQVDNVEETRYQ
                     AIHHQFIATALTKKLGKEINSDMMIGMMMADCTSYPEDCDPENVVFALKRNRLQYFFT
                     DVSFRGEYPVYIKRFFKENNINIVMEEGDDKILKENTMDFLALSYYYSTTVSASKNTM
                     NPTDNIKNPYLKANPWGWAIDPKGLYNTLSQYYDRYQKPIMIAENGFGMHDKFEDGKV
                     HDSYRIDYLGKHIEQIGEAIADGTEILAYCMWSPIDIVSCSSQEMEKRYGFIYVDIDN
                     NGNGSKKRYKKDSFYWYQNVIRTNGEELKEK"
     gene            complement(36114..36467)
                     /locus_tag="KR257_000493"
     CDS             complement(36114..36467)
                     /locus_tag="KR257_000493"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891397.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS lactose/cellobiose transporter subunit IIA"
                     /protein_id="HBH0029220.1"
                     /translation="MTIEEHIIDEELVEVAMQIILRAGEARTEIKHALNDLEKFDYRN
                     ADLKLAKAKGFMTEAHRAQTKIIQGEAGGEKRAHSLLFAHAQDTLMTIFSELNITMSL
                     VGIVKSIEYKVNNSK"
     gene            complement(36496..37743)
                     /locus_tag="KR257_000494"
     CDS             complement(36496..37743)
                     /locus_tag="KR257_000494"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003427247.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIC"
                     /protein_id="HBH0029221.1"
                     /translation="MGRVFMNKFIDFLSEKFTPVVNNMTKNIWVQSVQSTIMKVLPMV
                     FVGSLVTIVSVLKNYISFLPDLSPINQYTFGLLGLFIAFLLPMEIMKNKKFESMSVVA
                     GLAGAGLMLMMIRPEITNEGAIFNFNRFGGEGMLVSLVAGLFSGLIMSLFGSFSFFGE
                     DSALPDFVSKWFDNMLPITVIMFVGWGLIYGLNFDMFEIIVRVFKPVSDIAQTLPGFV
                     LLNFLVVFIYSLGISGWVLSPITYSIQLGAIAANAAAVASGGVATNIYVYEVIQTGWI
                     TLGGLGATLPLVIMMCLSRVGRIKAIGRACIVPSIMNINEPVIFGAPVAWNPFLMLPM
                     WIGTVVISITTYLSMSMGFVTIPSKVFNLWYVPFGISTFTVNQDVRGLIVLAINIVLL
                     FMIWYPFFKAYEKEEIKLESQEV"
     gene            complement(37751..38068)
                     /locus_tag="KR257_000495"
     CDS             complement(37751..38068)
                     /locus_tag="KR257_000495"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891401.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIB"
                     /protein_id="HBH0029222.1"
                     /translation="MKNIRVLLACGSGASTGFMATSMRKSAKKKGIEADIKARSESEI
                     DKYLSEIDCLLLGPHLDYMKEEIQQKANEYNVPVACISKTAYGRLDGAKALEEALELI
                     SNK"
     gene            38310..40223
                     /locus_tag="KR257_000496"
     CDS             38310..40223
                     /locus_tag="KR257_000496"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903449.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIA"
                     /protein_id="HBH0029223.1"
                     /translation="MKTSKKELFLNFIKTQHDWIDSSTLANYLNVSTRSIRKYVNEIN
                     SNGEFILSSKKGYKVNLNNNCQTKVDSSENISPDNRLNLILKELIVNSNGINIFDLSE
                     DLFVSPATIEGDIVKANKFIGSYNLKIKQSKFLLKLIGNESAKRKLMSSIIFKETGSD
                     FLSLFDVQKIYQEYNLTKLKENIIYILKKYNLFINEYAINNILLHLMITIDRIKKNNY
                     IESVEVVNYIDNNNDISISRDISNFLESEYNITLTSAELYYLVFQLTNKTTVLNYHEM
                     DTKSLPNYIDEHFVKLTKKIIKNVYDLYFIDLSDDEFVVKFTLHVKNLISRAKNNQVL
                     RNQIPQKLKDSYPLIYDISVYICNQIQILENIEIDEDEISYISLHVGSFFDRQKLLED
                     KILCALITPNYYDLQFKIVRDLEKRFNESIEIIQIFSDTHNLDFDNKVDMVITTLPIS
                     DRCPIPFVYVNPYLNRKDYDNIQSKFIQIKDRKNILTVQNHLEMYFSESLFMKNIYLD
                     SAKDYIRFMGNILYENKYVKPNYIDDVLIREKMSSTAFNNNVAIPHSMKMDALKTGVC
                     LIVNDKPVKWGEEKVQIIAMIPINEKEKEKFNYIFESFIEILSEWNNVKELTKADNYS
                     SFMNRIAYLIQNI"
     gene            complement(40346..41500)
                     /locus_tag="KR257_000497"
     CDS             complement(40346..41500)
                     /locus_tag="KR257_000497"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891405.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycerate kinase"
                     /protein_id="HBH0029224.1"
                     /translation="MKILISIDSLKGSLSSIEAGNAIKKGILKVKEDAQVKILPLADG
                     GEGTVDALVQGMNGKKDTIEVTGPIAKKVDATYGLLKNTSTAIIEIAQASGLTLVPTE
                     LRNPLYTTTYGVGEIIKEAINKGYRNFIVGIGGSATNDAGIGMLQALGFEFYDENNKL
                     VGLGGKVLNEIRHIKIENRLKELDECKFKIACDVNNPLFGKNGAAYIYGSQKGATSEI
                     IEELDNGLRNFSKVVKNYLSKDVANVEGAGAAGGLGFAFLAFLNSKLESGIKIILEEI
                     KLEEELKDADFVITGEGRLDNQTAMGKAPIGVAKLAKKYGVKVIGLAGATTEDAVKCN
                     EEGIDAYFSIVNRAMTIEEAMDKATASENMTATTTQIFNLITSIQQSKNM"
     gene            complement(41760..44375)
                     /gene="mngB"
                     /locus_tag="KR257_000498"
     CDS             complement(41760..44375)
                     /gene="mngB"
                     /locus_tag="KR257_000498"
                     /EC_number="3.2.1.170"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728444.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="mannosylglycerate hydrolase"
                     /protein_id="HBH0029225.1"
                     /translation="MKKNVHIVPHMHWDREWYFSTEESRILLVNNMEEIMDMLENNHN
                     YPYYVMDGQTAILEDYLAVKPECKERIKKLVQEGRLIIGPWYTQTDEMVVGGESILRN
                     LLYGIKDCDEFGEYMKIGYLPDSFGQSAQMPQILNGFDIKYSMFWRGCSERKGTNKTE
                     FNWKSDDGSSVLVQILPLGYAIGKYLPMNEDELRTRMDKYLPVLDKGATTDHIILPNG
                     HDQMPIQKNIFEVIYKLKECYPERKFFLSRYENIFKELEKNEDIDTIKGEFLDGKYMR
                     VHRSIFSTRMDIKSANARIESKITNILEPLASIAYSLGFEYHHGLIELIWKEIMKNHA
                     HDSIGCCCSDKVHHEIMNRFFLAEEKVDQLITFYKRRIVDAMSCEMALDKLVAFNLMP
                     YDRNEIVSAQVITKMKAFEIFDKDNNKLDFEVVHKEVIDAGLIDRQIVHYGNYDSFMV
                     YTINFKDKIPAMGYKAYMIKEVEHMLEKAYEVCDMVDNDFYTIQVNENGTLKIFDKKL
                     NKTFENVLLMENGGDEGDEYDFSPLPNEKLIFNDNIVANSTIKKNRFNNEIKINYRLK
                     VPKDIQARKNNRADSFIDFDIVINVPNDKAIIDVVFNINNQARDCRVRTYIPTNIASK
                     FSVSDNQFGHIKRSVYDDAMEVWQQEEWSERPDSIYPMLTFVGLSDKEHGVAVLTNST
                     REFEIVGEKFDTIAITLFRSVGFLGKEEMARRPGRPSGIKLPTPDSQMIGDIKIDLAI
                     VTHEKSTLEANVANMAKEYLTKIQTYNKMPYNAMKLNQSEIEVDYSYSLLKETNKDLV
                     LSVVKKAEKQEALVVRFYNSKEETKSANIVFNKNIKTAKWINLNEKELESISIDNNSV
                     NVECLMNQVKTILVK"
     gene            complement(44519..46444)
                     /gene="mngA"
                     /locus_tag="KR257_000499"
     CDS             complement(44519..46444)
                     /gene="mngA"
                     /locus_tag="KR257_000499"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728445.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS 2-O-a-mannosyl-D-glycerate transporter
                     subunit IIABC"
                     /protein_id="HBH0029226.1"
                     /translation="MEFKKITNENLVFLKQKIKTKKDAIKFLARKLYDEGKLTSYEEY
                     LEAVMYRETLSPTGFERGLAIPHGKSKSVKEAAFAAMTLETPIENWESVDPNNKVEII
                     FLIAVPENEGGNTHIQILSELVTRLSNEDYMNMLLNSKTKKELFNNLDIKEKKEQIKE
                     EIRIQNESKKIILAITACPAGIAHTYMSAEALIKAGKEIGVDVYVEKQGANGMVDPHT
                     PDIIKRADAIIYATDVAPKNTERFEHLPNIKTSVAAPLKRAKEIIYEALEVAQKQGKG
                     DYIEKSSDISYCEKSSWKKDVKSAILTGVSHIIPLIVAGGMILAFAVLASQAFGLQEL
                     YNQEGSWLWQLRKLSGGMLGTLMVPVLSAYMSYSLAEKPGLGPGFAAGLAADLIGSGF
                     LGGMLGGLLAGYIVKFLKKNIPAKGTLAGFVSFWVYPVVGSLVVGLLMLFVVGKPVAA
                     LNNGLINWLNGMTGVNAILLGAIIGAMVSFDLGGPINKAAYTFAIGAIASGNFIPYAI
                     FASVKMVSAFGVTIATVLGRDLFSESEKEIGKQTWILGLAGITEGAIPFMIEDPIRVI
                     PSLVAGSAITGSIVAFFNIGLQVPGAGIFSLALLEGSMSGFIIASIWFFAAVLGAIIS
                     AVLLIITRKQKNQRKIH"
     gene            complement(46574..47299)
                     /locus_tag="KR257_000500"
     CDS             complement(46574..47299)
                     /locus_tag="KR257_000500"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898159.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MurR/RpiR family transcriptional regulator"
                     /protein_id="HBH0029227.1"
                     /translation="MEFYERAKKYEYKFTDTEDMIIEYMRKNKEEIVKLSIQSLADKF
                     FTVPNTIVRLCKKMEYDGFSQLKNNLKEELKNEDKEPKNGFESDIKKTLELIDYEKIN
                     KVADIIQKSRSIIVYGIGQNIPLCEILVKEIRGGHDNITYYSQRHEVLHDIGKLGEQD
                     MFFALSLSGETKEVIEVAKTAVNKGCKVVALTHICENQLQQIADISLYCYSTIKQVNG
                     YNISDKVPIMMIMRAIIEQYWLR"
     gene            complement(47562..48332)
                     /locus_tag="KR257_000501"
     CDS             complement(47562..48332)
                     /locus_tag="KR257_000501"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003439975.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ChbG/HpnK family deacetylase"
                     /protein_id="HBH0029228.1"
                     /translation="MKKLVVRADDIGYSEGVTLGIISSYKNGIVTSAGIMVNMPFSRQ
                     AIEMVKNDDVCFGLHVNLVIGEPCCKEHIKIKNLLDEGGKFVSSKIRRTQLLTGKEVF
                     NYEEVYEEVCAQIETYKLYMSKLPEYIDIHGIEEDVSISAMCDAAKEYGIPSCPYYLD
                     SCISMPSKYPQNDFYKLNKSFVKLFEEKYINLDKDITLMVTHPGFIDYSLIKSSSLIQ
                     ERVYEHAMLCDKEVKMWLKRNNIELVDFKDIFKSNNYI"
     gene            complement(48334..49761)
                     /locus_tag="KR257_000502"
     CDS             complement(48334..49761)
                     /locus_tag="KR257_000502"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903457.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS transporter subunit EIIC"
                     /protein_id="HBH0029229.1"
                     /translation="MMQQLSLLGKTMLVPIAVMPAAGILGLLFGPNMLNVPAISNISN
                     IVFSNVDYLFLLGAASAYSKSKDKTSVMVAAVVAYMIFKSNLELLNDTLNAGVFGGII
                     VGACIAWTYNKTYKVKVPAFLSFFAGEKCVITLSPVVALILSYIFSLLWIYPQAAMNQ
                     FGFWLGGAGAIGIFLFLFCNRALIPTGLHQVLNAYILFEMGEYTTSTGEVIRGEIPRF
                     MAGDPNAGFFWTGFYIIMMFSIPAISYAIYKTAQDKKKQEVKGAMTAGALTSFMATVT
                     EPIEFSFLFASPKLYIIHSFYSGLGGVVLYLLGVRLGSFNGASIIDYVLSFSYGDKAW
                     LVIPVGVVFFVLYYVTFKYIIIKDNVQTPGREVEIEIGDKVSEKEKNLKLSHGNFSYM
                     AKQIIKNCGGYENIVTLNNCMTRLRLEVKDATILNDDNIKKTGAKGVIKLSNTSVQII
                     IGTDVVKVKDEMEMQLDELRKQADA"
     gene            50152..50874
                     /locus_tag="KR257_000503"
     CDS             50152..50874
                     /locus_tag="KR257_000503"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861813.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GntR family transcriptional regulator"
                     /protein_id="HBH0029230.1"
                     /translation="MAKNKFSEIYEVLKEEILDGKYTSNMMLPTELQLIERFSCSRNT
                     VRRAISQLNTEGYVQSIKGKGVVVLENSCSNDFFLNMHNFKGVESIVEDKKVNTATSV
                     LHFSKILIDNKLSKKTGFKVGSEVYYLHRLRYIDNIPKILDINYFLCSIVKDLDVSIA
                     QGSIYKYIEECLGTKIVSSRKIFKIEKATELELKTLPLNDYNCVGVIKNSVYTDDGKL
                     FEYTESKHTPETFVFMDVTQRY"
     gene            51071..52738
                     /locus_tag="KR257_000504"
     CDS             51071..52738
                     /locus_tag="KR257_000504"
                     /EC_number="3.2.1.93"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898161.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha,alpha-phosphotrehalase"
                     /protein_id="HBH0029231.1"
                     /translation="MKNWWKKATVYQIYPKSFKDSNNDGIGDINGIIEKLDYLYYLGV
                     DLLWLTPMYVSPQRDNGYDIEDYYNIDPKYGTMSDFEKLLKEAHKRDIKIMMDMVLNH
                     TSTEHKWFKESKKSKDNPYRDYYFWKDAKPDGSVPNNWISRFSGTAWKYDETTNQYYL
                     HLFEETQADLNWENEKVREECYKILEFWADKGIDGFRLDVVNLLSKTPGLPDDPITGP
                     KGDGRTHYADGPRIHEYLHNMNQKVFKPKNIVTVGEMSSTTPEECINYTRENREELSM
                     VFSFHHMKTDYKGGAKWTNEMFSLDKLKKAQSDFQYKMYEGKGWNALFYSNHDQPRAL
                     SRFGDDRFFRQESAKMLAITLFGLQGTTYIYQGEEIGMTNAYFTKIDEYDDAESKNAY
                     YHMIKSGIDEKEALLILQQKSRDNARTPMQWDNTIYKGFSNHKPWLKVNNDNISVENE
                     LNDSRSVFYTYQRLIKYRKQYDIFTEGTYRLLDENHKNLFVYEREYKNQNLLVISNFT
                     HDNVVYKLPETYLNKLNYTILETNYTRDIIENKMEIKPYESIMIYYK"
     gene            complement(52834..54153)
                     /locus_tag="KR257_000505"
     CDS             complement(52834..54153)
                     /locus_tag="KR257_000505"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003439983.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amino acid permease"
                     /protein_id="HBH0029232.1"
                     /translation="MEKGIKLGFWSIVLLGINAIIGSGIFGLPGDAYTDIGPASILVL
                     VFCMLLAVSIALCFAEAGSWFDTDGGPYLYAKEAFGDFVGFEVGFMKWIVSMIAWATM
                     ANFFAVTLSSVWPQAAEPLIKNIIIGILVVGLGIINFMGMKQSKHLNNIMTIGKLLPI
                     VLFIAVGLFFIKGSNFTPFVIIQKGQSASSAFVAVSITLFYAFTGFESLAVAAKDMEN
                     PKKNVPKALVMVMFVVSVIYMLILGISIGVLGNGLAGSATPVADAAIKMLGPIGGYII
                     TIGTIVSVGGINIASSIFTPRSAAALVEQGLMPKSIRQTNKNGAPYIAIIVSVIGTLL
                     IAWSGSFTTLSQISVVSRFIQYIPTCLAVLILRKKYAGKDVNFRIPGGAIIPIFAVII
                     SILLLIKAGIDEPMKIVWGLGGMIIVVPIYFYMTKVYSKKYNDVEVK"
     gene            complement(54194..54940)
                     /locus_tag="KR257_000506"
     CDS             complement(54194..54940)
                     /locus_tag="KR257_000506"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012816377.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="gamma-glutamyl-gamma-aminobutyrate hydrolase
                     family protein"
                     /protein_id="HBH0029233.1"
                     /translation="MKKLAKKKYPIIGISGNLLIDEGGMFPGYERAYVNNDYIQSVVM
                     CKAIPYIVPIVYDDEIIKEQVSNIDALILSGGQDVNPLIWKEEPHNKLGAISPKRDSF
                     DMKLLKHALDMKKPVLGICRGEQIINVTEGGSLYQDLSLIEGAYIKHNQQHLSNVPTH
                     TVQIKEGTKLYEILGEKEVLVNSFHHLVVNKVAPGYIVSATSKDGLIEAIEKEGSEFV
                     IGIQWHPEMMTRDYDNMKKIFMAIVKEASK"
     gene            complement(55184..57193)
                     /locus_tag="KR257_000507"
     CDS             complement(55184..57193)
                     /locus_tag="KR257_000507"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003427266.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sigma 54-interacting transcriptional regulator"
                     /protein_id="HBH0029234.1"
                     /translation="MKTIAVVTDGLSKLECFLNKNLEMIFKDKVMIKNYYLNKITEKE
                     LIKDDIILVMIDDRVLKIKKYVEDVSKIITINRSIKQKDIYKLFSLPEGIDVLVVNDN
                     KHTVLETISNLYNIGINHLNFIPYNPNEEYRNIKIAITPGESSLVPKYIEEVIDLGHR
                     YIDSSTFIQIIAKLKLDDKEITERLIKYTDEIISLYSGINTKYKELTIKADELNSIIN
                     LSNLGMAMVSDKGNIIICNNSLRDILDIQSNIIGKNIDELENENIKKIFSLSKAHDEV
                     IKFNNKYLNVNKYNIESFGRVTGYYFCIQEITYIRKLEQNLSKKLREKGQVARYTFDD
                     IKTVSTKMERTKKLGMKIAESDYTILITGESGTGKELMAQSIHNASPRHSQPFIAINC
                     AAMPENLLESELFGYEEGAFTGALKGGKKGLFEQANNGTIFLDEIGDMPIYLQSKLLR
                     VLQENQVMRVGGENVIDIDVRVIAATNKNLLEMIKGDRFRADLYYRINVLPINIPPLR
                     ERKEDIEVMLKHFMKRKRAISQDVQDIINAYEWPGNIRELKNTAMYINIMSSEDVILI
                     NDLPHNLLNITEDFSKEISILKDRTSIEKVKLVMECLKNANNLNKNIGRNGIVNSINE
                     LGYNITEGEVRGILNMLKELDLIICESGRKGSELNRRGKNILNSI"
     gene            complement(57587..59020)
                     /locus_tag="KR257_000508"
     CDS             complement(57587..59020)
                     /locus_tag="KR257_000508"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861817.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycoside hydrolase family 1 protein"
                     /protein_id="HBH0029235.1"
                     /translation="MALRKDFLWGGATAANQCEGAWNLDGKGPSCSDMCTGGSQKVSK
                     RITRVIEKGTFYPSHEAIDFYHRYKEDIALFAEMGFKVFRFSIAWTRIFPTGMEKEPN
                     EAGLKFYENVIDECLKYNIEPLITISHYEIPFAITEKYNGWVSRDVIDLYMNYCETIF
                     KRYKGKVKYWLTFNEINSATMPMGGYLSQGILNEGTTDFINQVDIPQLRFQGLHHQFV
                     ASAKAVKLAHEIDSNYQVGCMQIFATMYPYTCNPDDAVKTQRDSRVMNYFCGDVQVRG
                     EYPTYMNRYFGENNIEIKMEKGDLEILKEGCVDFYTFSYYMSTCVSSDSKEDNTSGNI
                     LGGVKNPYLKSSEWGWQIDPEGLRYALNEIYDRYRIPMMVVENGLGAYDKKESNGVIN
                     DDYRIEYLKAHIEQMKEAVEDGVDLFGYTPWGCIDLVSASTGEMAKRYGFIYVDKYDD
                     GSGDLSRIKKKSFDWYKQVIESNGERL"
     gene            complement(59107..61023)
                     /locus_tag="KR257_000509"
     CDS             complement(59107..61023)
                     /locus_tag="KR257_000509"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898181.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS glucose transporter subunit IIA"
                     /protein_id="HBH0029236.1"
                     /translation="MRKYEQLSKEIIANVGGKDNISSLSHCITRLRFKLKDESIANDD
                     VLKKMDGIVTVMKSAGQYQVVIGNHVPDVYEVVCDLAGLGGDTIDNSDSDAPKGLLNK
                     FIDIISGVFQPILGVLCAAGMIKGFNAVFTALGLYGETDGAYIMLNAIGDAMFQYMPI
                     ILGYTAAKKFKLKPFIGMLIGAVLCYSGIQLDTLASTGQPLYNLFTGTIFESPVYITF
                     LGLPVIAMNYTSTVVPVILIVLLAAKLEKVFAKIIPDVVKNFFVPMAVLLVSLPLGFM
                     VIGPIATYASNIVGNGFLALFNFSPILCGALTGLLWQVLVIFGLHWGLVPIAMSNLMT
                     MGFDTILVGVFVPSFAQTAVVAAMYFKLKDKKIKELCIPAVISGICGVTEPAIYGITL
                     PRKTPFIYSCVGGAVAGAVMGIMNVKSYVMGGLGIFGIPNYINPTTGDMKGVYATIIA
                     IIVAIVVGFVLTLFFWKDDAIVEISKDDNGQGVIEKNKREVVYSPIKGEVKALEQIQD
                     AAFSTGILGKGVAITPKEGKVVAPFDGTVMTLFPTKHAIGIISDNGCELLIHIGLNTI
                     QLEGKYFKSFVNQGDKIKKGQTLITFDIESISKEGYCLETPVVVTNYSDYVDIVENTQ
                     KHVNNSQKLITVLA"
     gene            complement(61097..61957)
                     /locus_tag="KR257_000510"
     CDS             complement(61097..61957)
                     /locus_tag="KR257_000510"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003439998.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PRD domain-containing protein"
                     /protein_id="HBH0029237.1"
                     /translation="MIIEKILNNNVIITTDENHKEIVVMGRGLAYKKRTGEHISKDKI
                     DKIFKLSDPNISDKFKELIADIPIRYMELSDEIILYAKEKLGKRLNDSIYISLTDHMY
                     TAIERAREGVSVKNVLLWDIKRFYKSEFKIGLEALDYIEKKFEIRLSEDEAGFIALHI
                     VNAQMDQSIKTIYEITQIIQEISNMVKYHYRIVFDEDSVYYHRFITHLKYFAERIVSN
                     NLHENNEDDLLNVIKVKYKNAYKFIEKLDEFIHKKYNYDLTDEEKLYLTIHVERVVSK
                     SIKSDINPNN"
     gene            complement(62308..63495)
                     /locus_tag="KR257_000511"
     CDS             complement(62308..63495)
                     /locus_tag="KR257_000511"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003439999.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="M20 family metallopeptidase"
                     /protein_id="HBH0029238.1"
                     /translation="MIESIKKRAYEIENELGKEIEEVCNFIFNNPELGEEEYISSKYL
                     VEKMKEYGFDTVYPYCNMETAFRAELGDNDGPTIAFLAEYDALPGYGENKEPAHACGH
                     NWIAASTLGACIVLSKLKENFKGKIVLIGTPAEETTGGKCDLVKAGAFDDVDVSYQMH
                     IEAFNNINCKALAIDSLEFSFEGVSAHAASHPHMGVNALDAVQLTFAGINALRQHVKS
                     DVRIHGIVSNGGEAPNIVPEKAACKFFVRAAERSYLDEVTKKVINCAKGAELMTGAKL
                     SYRYFENSFDNIINNKVLQKITKNNLIEAGITDILEGKDGPVGSTDIGNVSQVCPTMY
                     TEIALDISPMVYVHEKEFLNYANSEEAYDKLHKAVKAMVGCALEIYLEDGLLDEIKKN
                     HLN"
     gene            complement(63509..64900)
                     /locus_tag="KR257_000512"
     CDS             complement(63509..64900)
                     /locus_tag="KR257_000512"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422454.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YfcC family protein"
                     /protein_id="HBH0029239.1"
                     /translation="MSSLKKKKFTMPQTLTIIFLLIVLMAILTWIVPSGNFERVDIDG
                     RSVVVAGTYEKAPSNPQGITDVFTAPINGFIDAAEVVGFVLIVGGAFGIVNKTGAIEA
                     VIAHTVNKMKKFQFLIIPISMILFGLGGTTFGMSEETLPFYMIFIPLMTSMGYDSLTA
                     VATVFIGATAGFGAATTNPFSVGIAQALSQIAPGSGIEFRVVMFIIYMAISIGFVMMY
                     ANKVKKDPKKSLVHDISLNQESMVNSDTNIKEFTKREAMVIAIFTIGMAIMIYGVLKL
                     GWYITEIAMIFTAIGIISGIASGLKQDDIVNSFISGAGDLMTAGLCIAFARGIVIIAE
                     NGFIIDTILNSAANLLNGLPKTIFINLTFLIEGLIAFLIPSASGLASLTIPVLAPLGD
                     LVDVSRQMIVTAYQFGIGVTNLITPTSGVLMGALAVANIPWSKWVRFVIPLMVVLTIL
                     VMAFLTIGLYLGF"
     gene            complement(65495..67195)
                     /locus_tag="KR257_000513"
     CDS             complement(65495..67195)
                     /locus_tag="KR257_000513"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422452.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS transporter subunit EIIC"
                     /protein_id="HBH0029240.1"
                     /translation="MHYIAWHFNKNGGNNTMKDKLQVLSGAMMIPVILLVVAGVFIGL
                     GSAFANMENVSALGLSGLIKEGSFINVFFKVINDLGFMVMRYLPIFFVTGIAFGLSKK
                     EKGWGALGGIVLFIGMHTVISTLLAANGINSDTVTAEAFMASGLGEAEAYSRSSLYGS
                     FLGIFSYDCSIFGAIIAGFVASAVHNKFVDIELPSALSFFSGPRFSMIMMFIASIVLG
                     TAMYFIWPPVGLALSKLGNWIGSSGLLGTFTFGAMDKALLPFGIHHLIAFPIEYTRVG
                     GTMEVGGAIYEGVNNIRLAQMGDPDTLSYITRNFTTGRLLIHFAILPAAALAMYKLAD
                     NANKKKAISILIPAIVTAMLVGVTEPIEYTFLFVAPLLYFVAYVPLAGLTYVFTEMFN
                     VSIMGESFRNMFPNLLQPQKVDALPLLFLIPIFFIVTYIIFTWAIKKFDIKTPGRSSE
                     EVKLYSKKEYRERQSVDAGKTAYNNAVEEEVDDKDTKLVHSIIEGLGGSNNIKNVTNC
                     ATRLRVELNSIDGFYEDGFWVNELGASGVVKKKNSVQVIFGPRVITIASKLKAVLGVD
                     "
     gene            complement(67167..68570)
                     /locus_tag="KR257_000514"
     CDS             complement(67167..68570)
                     /locus_tag="KR257_000514"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891439.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="M20 family metallopeptidase"
                     /protein_id="HBH0029241.1"
                     /translation="MIVNKELIIDYLKSNQENIINDIRSLVEIPSIRDESTTDINQPF
                     GIEIRNAFDKLIQIAKDKDFVVKDFDGYAIHIEYGEGEEVVGVLNHIDVVPIYNKELW
                     KSKPFKVCQKDNYLYGRGVNDNKGPLIGILYALLFLRELNEKPKRKIRLIVGGAEETT
                     WECMEHYFSVNEQPKFAFSPDGNFPIVNGEKGILYFNLRKKIDKDKFRNHNLVDIKSN
                     KEDGFVCDKIEAVFKTNDKKDLVESLAYYTEIEELEEGKVLVRYTGERALSRNPHRSY
                     NCAFSLAKDLEKIKKLNDKGVIIRDILNSYFTDDNHGKKLGIYKEDVDMGVSTICIMS
                     IFLEKNELNMKIDFRYPKGISWEFITNRINEIGKKENLIVDIYKDLKLLYVKPDSELI
                     NKLSNAYKQGFGKEAELFTKGAASYARVLKNGVAFGPTIEGDNPNSHQANENISIDTL
                     YKAIEVYIYALYSLAFQ"
     gene            complement(68834..69325)
                     /locus_tag="KR257_000515"
     CDS             complement(68834..69325)
                     /locus_tag="KR257_000515"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728636.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS glucose transporter subunit IIA"
                     /protein_id="HBH0029242.1"
                     /translation="MFNIFKKKENKIEKIYSPFKGNLVNLEDVPDAVFAQKMMGDGVA
                     IIPSEGKLYSPVDGEIVNVFDTKHAIMIKSNDNTNILIHVGLETMSLEGKPFDVKVKA
                     GDKVKAKDLIMEVDLDFITSNDLNIITPVVIMDDADSVKRTVKDRIEPGNVDINSIIM
                     EVE"
     gene            complement(69351..70163)
                     /locus_tag="KR257_000516"
     CDS             complement(69351..70163)
                     /locus_tag="KR257_000516"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003440004.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Cof-type HAD-IIB family hydrolase"
                     /protein_id="HBH0029243.1"
                     /translation="MRYKLICTDMDGTLMGKGFEVSEENIKALKEVMEKGIKVALVTG
                     RPYNAMKYFTSVLGDDIYIISTNGTYFKLLGYEYKKVLSKEALKKIYTIGEKYNLSKH
                     FKGCKIVISNNEIGEEHPYRLINSKNKEEDRIEIIENASCETLLEKADNEILKCILFS
                     ENVDSLREAKEEFKKQEDLEVVSSGKINFEVMSKGTSKGIAVKKFCDILGIDSKEVIC
                     IGDNENDISMIKFAGLGIAMGNATDEVKSMADFVTDTNVNDGVAKALRKILS"
     gene            complement(70176..71327)
                     /locus_tag="KR257_000517"
     CDS             complement(70176..71327)
                     /locus_tag="KR257_000517"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422425.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="iron-containing alcohol dehydrogenase"
                     /protein_id="HBH0029244.1"
                     /translation="MINFYQPSRINFGQGTLSELPRIIGKYGKKCLLVTTPNVEPLDK
                     LYKRVTLNLIEKGIEVVHFDRVEPNPTVELINEGFELAKKESVDVVLAVGGGSSIDTA
                     KVLALTFGLEKIDWDYMFSTYTNPFKIYDKVSEKELPLIAVSTTSGTGSQVTQAAVIS
                     RGSEKNTIFHQNCFSKECIVDPELMLTLPERITASTAFDAFTHAFESYINPNANDFTE
                     IMSEKSMELVINYLPKVMEDKNNIEYRTKLAVADTLGGSSLANAGAAAPHPLSEIIGG
                     VTHIPHGEALAIVFPKFAEKFYKDNIEKFAKVARMLNQELEKVEDDEAAKTLGNEIES
                     FLKRVGLKTKMSEFNVTKEQLEQITSCPVLGFLPFGKKEDLVEILEKSY"
     gene            71597..72238
                     /locus_tag="KR257_000518"
     CDS             71597..72238
                     /locus_tag="KR257_000518"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003427306.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aldolase"
                     /protein_id="HBH0029245.1"
                     /translation="MKYLIDSANLDEIQKCLKYGFKGITANPSMYLKEKVNFHEFIET
                     CANLNPEILTAEVIGNNLYELINSCDKILNINKNTIIKINFSEVGLELINILNSKGVK
                     TACTLIFNVNQASLAINAGADYLFPFIGRNDENGNDGIKNLTEICNLISINGYNTKVV
                     AASIKNVFHLTQASLCGCDYAAVTYDLFKKASFNQLTIDGANTFERDWSKVNK"
     gene            72264..73808
                     /locus_tag="KR257_000519"
     CDS             72264..73808
                     /locus_tag="KR257_000519"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422422.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcription antiterminator"
                     /protein_id="HBH0029246.1"
                     /translation="MNKRLLDIAELLLNSSDYITVDTIAEELKVSNKTIRNDLVILDE
                     WLLEFNLSLDKKTGSGVIILGNEDIKLKVIRDINDKSNCIYAYSPEDRKRYILSKLFI
                     KNSKFRIRDICNELHVSRATVHKDLVVIQNFLQNFKVTLVRKTNNGVYLEGKEKDIRK
                     AIFELATVNKSYTELKEILFSKSNECKDTPSTKIFKELFNYDFEKLSQITLHTLQVEK
                     SNLSDEYYINFLIHIAICIKRISIKRYINLSEGFFRELLEHEYFEKSKILCANLSEAF
                     DVEFIDEEVCYILLHIEGLLKSIKKTTTLEPLKNEEITEYNLSEAIAVHWGSILNLNL
                     KDDLILIKSLANHLKSVLHRINYGFTITNPILNDIKRTFPYTYKAAKESNTVIKQLMN
                     YEVNDDEIGYLALYLISAIDRSKSPLNTILICHCSDGVSNLLVQKLSFEFNQINIVKS
                     IPLSSISFTNFDDVDLILTTAPVDFEHNAELININALLSKNDISRLSTIIKKLYSEKN
                     KILSYK"
     gene            complement(74008..74634)
                     /locus_tag="KR257_000520"
     CDS             complement(74008..74634)
                     /locus_tag="KR257_000520"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003427309.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YitT family protein"
                     /protein_id="HBH0029247.1"
                     /translation="MKKEMIKDYLLITISAFLMALAVNFFFAEHTLAPGGITGLSVVL
                     STFLSMPVENISLGISMPLLVMGLLFLGKGFGIKTLYITLMGPLFLKVIPQTHITDNL
                     LVAGVIGGLLVGTAIGIAIIRGCSTGGTDLVAMLINKVIKFLKLPVILFMLDGFIIVA
                     SGIISKNFMISIYSLISLLLIIKTIGFVTTKFGKNTEEINNINNACAQ"
     gene            complement(74769..75485)
                     /locus_tag="KR257_000521"
     CDS             complement(74769..75485)
                     /locus_tag="KR257_000521"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422419.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pentose-5-phosphate 3-epimerase"
                     /protein_id="HBH0029248.1"
                     /translation="MKHIKIAAGLAHVNYGHISAVVKEAMDAGVDYVHSDAADMHDLK
                     NMQLMGGHQIIEAIRPVTDKPIECHIYTRDCDRLFIEKIAAAGCNLLIIPAEHFLGAP
                     LAYIINYCREFGMKVGLTIGCYTPLCFVDEAIYDIDRLQIVVHGVDETDGKDNWGWRK
                     SAVDLVKRARKMIDEKNPKCELAIDGGLRADNMEPLIECNPDVVILSSAIFKDKDGIT
                     AGVKNCRKAIDKAATKFGLE"
     gene            75911..77125
                     /locus_tag="KR257_000522"
     CDS             75911..77125
                     /locus_tag="KR257_000522"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891452.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="6-phosphofructokinase"
                     /protein_id="HBH0029249.1"
                     /translation="MRNCIIAQSGGPTAVINASAVGIYEKNLETKYFDKVYFGINGIE
                     GILNKNIIDSDSLNKDNVLNLKQTPSSGLGSCRYKLADYKINSYDYDRVINILDEYEI
                     DTLFYIGGNDSMDTVMKFSQYCKNTTCKIKFIGIPKTIDNDLLGTDNCPGFGSAAKLI
                     STLIMETYLDFSIYKNNGIFIVETMGRDTGWLAASSSLARLNDTPLVDLIYLPEIDFY
                     EDKFIEDVRKIFKEKNKAYIVASEGIRDKYGNFICEQKTSAHDKFGHSQLGGVSNYLK
                     NLIVSSSITTRVKTLELGVIQRCAMHLASDTDLKQAAEVGAYGIELSKKGYTGVMAII
                     NRTCNNPYKYEVSHTDISKIANKTKYFPKEWINEECNYITDEALNYLYPLIQGKPDIK
                     YKNGLPYFSIIY"
     gene            77745..79073
                     /locus_tag="KR257_000523"
     CDS             77745..79073
                     /locus_tag="KR257_000523"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422415.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0029250.1"
                     /translation="MMKIAVITTEFLKEFVDNSIKKLNINAEIEIYIYRDFSHVGDLY
                     LEIEDRFDGFAVSGPIPKKAITKKAGTIKKPLVDFGTDLQSYYDMFLKLIFKYNTLDF
                     SRAYFDLTDWADNPKDISYYLSNGTFGDLMDSIDENASKMSLSDIAKLEKKIAKKHIN
                     LWNEGKIDFSTTRFSSIVPMLQNAGVNFHFIYPDIDLLKNTFNNLIKDIHLHRMKGNQ
                     PSVIYITVKDTNYDDSTLDQVYKILNSIKKDKLTDFIIEKNSNSFKIFTKCETIKSLT
                     KNFTACYIKESIENSTNIKVCVGYGIGNDIKQAMSSAISANKESKINHLNYSFLVNEN
                     YETIGPLLCDKLLTVSNKVTPHINTIAKSSKLSTLTIQKIISVTEILQRDEVTPKELS
                     SCLNVTVRTANRFLSSLLKSGNATILYEKQNSTKGRPERVYKLFISENKY"
     gene            complement(79201..80391)
                     /locus_tag="KR257_000524"
     CDS             complement(79201..80391)
                     /locus_tag="KR257_000524"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861827.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amidohydrolase"
                     /protein_id="HBH0029251.1"
                     /translation="MKNFFKEAQSIEGEIIRWRRYLHENPEIGCNLPKTVTFVTSTLE
                     KMGYSPKLTSNNGIVAVLDSKNGGKTLLLRADMDALPIMEETDLPFKSKNKDASHSCG
                     HDNHTAMLLGAAKILMDNKHLLKGRVKFVFEPDEETTRGAKSMIDDGILENPQVDAAM
                     AFHSMVGKFLNTGQVAYSRGPAMASADIFEITVEGKATHGASPEFGVDPINIMSHIQI
                     ALNTILSREKPQKEPVVLTIGMFNAGSVPNAIPNKASMSGTLRTFDQSVREKLKNRII
                     EISTGIAKSFGGNAKVEFKMGTPAVINDLDVGDEIVSYVKEVIGNENVIDFPSAMGSE
                     DFSEILLRVPGVFLWIGMGSISQGYNFGMHNPKAIFNEEGLVYGSALFAHCAVKWLEN
                     NFSR"
     gene            complement(80497..81876)
                     /locus_tag="KR257_000525"
     CDS             complement(80497..81876)
                     /locus_tag="KR257_000525"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422413.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amidohydrolase"
                     /protein_id="HBH0029252.1"
                     /translation="MIGSISINEIDKKRFKLDDLSKKIWENPEKAFKEFKACENTANF
                     LRSEGFDVEVGVGGLATAIRASFGSGKPVIGFMGEFDALPGLNQKVSTKQEAFELGAY
                     GHGCGHNLLCTAHVGAVVGLKREMIENNLSGTIVFYACPGEEQLTGKGFMARGGAFEG
                     LDLAINFHPNKISEATIGTSTAVNSVKFHFKGKTAHAGSDPQNGRSALDAVELTNVGA
                     NYLREHVTSDVRIHYTITDGGVAPNIVPDKASVWYYTRALSREAVESTYERLVKVAKG
                     AAMMTETEVEVEFLGGCYNTLNNHVLANLVSECMNEIKQEPWTREELDFAAELDRQSP
                     QQYKAMISKYNLPEGTHLYYGGGNVTNFNSYGSTDIGDVMHIVPTAYFFTGCTNLGAP
                     GHSWQFTSCAGSSIGEKGMIYASKIMAMFGAKILNNPEIAKKAKEEFDKSMNGKTYKC
                     PIPDDIPTP"
     gene            complement(81907..83115)
                     /locus_tag="KR257_000526"
     CDS             complement(81907..83115)
                     /locus_tag="KR257_000526"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422412.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0029253.1"
                     /translation="MENFWNPLTCFTVCVMIYAFSEFLSKKTKGAISTLLFVCIIFLL
                     GFWTNILPKDITGASGILAAMSNFGIALLITNLGTLINLEDLCHEWKTVVIALVGIVG
                     IGVGCLTVGSMLFGREYALIAAPPIAGSTVAGIIVTTVAEAANRPELAAFVILVLSFQ
                     KFFGIPITTYCINKELKFKRDNGDFLKDESKSNFKLPSMRIFKEDLGKKSSTLVYLAK
                     LSFVAMIGNFVGLATLIPGFTPANYYLNPNIACLLVGLIFTRIGFLEKGILDKSQSNG
                     IIMFGCMLMLPGGLAKVTPTALFGMIIPTIGILVVGSVFIILFTAIVGKLLGYSPRMS
                     AAIGVTCMLAYPATQIISNEGIDAMEGTEEEKQRATDYLLPKMIIGGFVTVTIASVAF
                     ASIIGPIIFG"
BASE COUNT        27581 a        14886 c         9172 g        32311 t
ORIGIN      
        1 ggttttatat aaataaatcc ttaagtaaat attacatttt aactgttagc attacacttt
       61 tgtaacatat ggaagactat tataattata gtagaaatat cttaaaataa aagcatgatt
      121 tacttctttg tataaacaaa gaaaagaagc tcctaagaag cctctaatct atacaattat
      181 tcttctctat aaaaaaccaa aatacacatt gattgtggca aatacagata ctataaacaa
      241 gtgatattac tactatatat taaaacaatt attcctgaag ataattcaat aagactatca
      301 agcaataagc taagcatcca aaaagactta ataccattaa tgtataatta tacccaatat
      361 taatgcttaa aaaaccagca acagttggaa taatcagaga tgaacctccc ataaatatac
      421 ttaaagctat taattggcta ctacttctaa gttttttagg agaaacttca aatattaatc
      481 tttttgaagt aattaaaatt aaaggagtag aaaacacttg aaaaacacac agtataataa
      541 tgatatttga atcatttgtt aaagcaaata atagaaactg aactgttatc ataatagcac
      601 ttaattttaa taagtttaaa ctgctatatt tttttaataa ataagaacca gccagatatg
      661 ttggtatctc taacaatgac tgtaaagacc actttaaaga tatctgagaa tttgtagcat
      721 ttaaagctat cattttatct attacagtac agttatttgc taccaccatt gagtataata
      781 agaataaaat acatactagt aagatatatt ttttatcttt taataattca ataatatctt
      841 tattagttac atttattttc ttattaatct tttcaatatc aggtaataat agtatattta
      901 taataagtaa tactacaatt aaaccaatcg ctacagataa tccaaaatat gagaatctaa
      961 gaatcaagta agatgctacc atacttccaa tagcccatcc aatcgaccca aaagtcttaa
     1021 taaatgacaa ataattatta atattatctc cacaacctat tatccatgta tcatataaac
     1081 tacagcaagt atttaataat cctcctgata aagcaacaag taataagtat attataaaag
     1141 ttgcagattc agtagaaaac ataataactg atgcaattcc ataaactgat aaactaatta
     1201 aaacaatttt tttcattgtt tgatacttat cagctaatac tccaaataat aattgaaata
     1261 atatattggt tattgcataa ctcgataata taattcctct ttcaaacgct gagtaaccta
     1321 attttgataa gaaaggtgtg aattttgttg aagcaaaggc aaaaataata tatgagaaaa
     1381 aatagaatat gataaattta aatttaatcg ctttattaat cataatcaat caaaattgat
     1441 aactttaata ccactatttc cttcctgatt taagtttgaa agatgatatt ttaccgtatt
     1501 aggattctct acaataacta aaggaatata taaagtattt tcaagtaact tattatcaat
     1561 ttctactaac ttttccccca tattaacttc ttgaccttgt ttaacttcta atttaaagtt
     1621 ttcttttttt gttgttgcac tgtccaatcc aatatgaata agaatttgaa catcattttg
     1681 caatttaatt cctatagcat ggttagtttg agcaataaaa cttattactc ctttagtcgg
     1741 tgatttaaga atattgtcct ttgctatcat agcaaatcca tctcccatta ccttagttga
     1801 aaatacttta tcaggaattt ctccaagatt aattattttt ccatcaatgt atgaattaat
     1861 tgtaattgct tctttttttc ttttaaagaa cattatagac actcctctac ataattaact
     1921 ttattctaat tatcattaca aataacgata ttaagcatac tgcaattgag gaaaaaagag
     1981 ccttatagct ctttccccat tgtagttctt taatactgct tatgatttgt ttaattccaa
     2041 caaatttata aatataggta aacatgataa caatagttat tgtgtaaatt tggaatatct
     2101 gccctaataa gactaaatag aaagcaatca tgttttcttt tatctcttta ttctttttta
     2161 tattgtaaat aacatatgca ctgtatactg cactaaagtt agagattaaa tttaaacttg
     2221 cattaacatc attgtttaaa agttgtgaaa atgaaatatt tgtaaataat gatgtcaatt
     2281 ctaaatacac tatatataaa acaggtaata ttagaaaaca aaccataacc actgaaagaa
     2341 atatattttc atcttttaat actgctgtga tattttttat tttatttgtt atcatgtttt
     2401 tgttctcctt atttaaaagt tggccagaaa tccttattag ccacaatcat ttcatctaag
     2461 atttcttttg ctacttttgc acttggaaca gttttactca tagtaaacga ctgccataat
     2521 ttttgataac ttttttctat ccatgcttct acagctaatt tttcagaagc aacttgttgt
     2581 tccattaaac ctttttggaa agttggaatt ttacctatag acataggttc aaccatatct
     2641 tttccaacaa ggcaaggaat ttcaaccatt gcatcatctg caaaattttc aatagctcca
     2701 ttattaggaa caatcagtaa aaatctttcc tgagtattaa atgctaatgc acaagctaat
     2761 tcaacaataa attgagaatg ctcacttgca tcaaaccatg tatcccttgc tgtgccattt
     2821 tttataattc tttcacattc ttcgaatgta tccttttctc ttctatccat aatttcattt
     2881 gctcttgtat aatttggatt agcatgttca acagtttcat cagccattaa ataatatttt
     2941 aaataagtat taggtaatgt agttggttct atttctaata agtcctttgc tgctctcata
     3001 gtttctaacc aactagattc tttgtgttga ccttgaggtg taaattcctc atatcctttt
     3061 ttagcacaat attcttgtaa tttaggcatt aaatcatttc cttctttgtc cttaatactt
     3121 gtccaccacc cgaaatgatt caatccataa tatctaacat caaagtcttt acgagaattt
     3181 aaacctaaaa ctctagcaaa tatttcctct aaacatactg gcatatcaca aatattaata
     3241 attcttgaat ttggtcttaa tacacgacat gcttctgcaa ctatagctgc tggatttgaa
     3301 taattaagca tccaagcatt tggagaatat ttttccatat aatcaatcat ttcgattatt
     3361 ggacctattg ttcttaatcc ataggcaatt ccacctgccc cacaagtttc ttgaccaaca
     3421 accccatatt ttagtggaat tttttcatct tgttcacgta aagcatataa accaacacga
     3481 atttgtgcca ttacaaaatc aatatcagta aatgcttctt ctggatttgt tgtataacta
     3541 aatttaattt ctggattttt ctctctaaca attattgcac atgcttcagc aacttttctt
     3601 tgtctctcat cattattatc atataattta attgattcaa taggaaattt agcaacactt
     3661 tcaattaaca ttgttacaat tccagcagta taagtactac ccccaccagc aattagtatc
     3721 ctctgtcttt ttctttccat ctttccttct cctttataat aaattttcaa attcttctct
     3781 tacacttggt actgaaagcc caataataat ctgaatagct tttccattat gcactaaacc
     3841 atgtgcacct actgccttaa aatcttcttc tttagaaata attgagtcat ctttcaaggt
     3901 taatctcaac ctcgtagcac agtttgtaac atctacaaca ttttctgctc caccaactaa
     3961 ttttatgtat tcagatgctt gttgagaggc tttactcaat ttatttcctt tttcatcttt
     4021 agtttctaag tattcatttt tagtatatag ttttgtttct tcactatctt cttctctacc
     4081 aggagttttc atatcaaact tcttaattaa gaaagtaaat acaaagaacc agataaatga
     4141 aaatataatc cctacaacaa cttgaacaac atataccttc cagtgataca ttccaagagg
     4201 aagccaattt aatacaaccc agttaataat tcctccacca aaatcaccaa caactcctaa
     4261 ggcaaacgaa atcgtttgca agcacgcatc taaaaatgca tgtactagga ataaaagtgg
     4321 tgctacaaat aaaaatgtaa attctaacgg ctcagtaatt ccagttaata ctgcagtaag
     4381 agtagcagga atcattaaac ctaatacttt tttctttttt tctggctttg cagttacata
     4441 gaaagcacca aatacaccta atgaaccaaa caccttcgat aatccggata atgaaaatcc
     4501 gattggatac atttccttta gagtcttagc tgaagtttga aaatcctgaa tatgagtagc
     4561 ccaatatact gatgtaccac ctggaacaac aacactatca taacaaattg gtgcatatac
     4621 aaaatgatgt aatccagttg gtattaaaat cttttgtaag aatgcataac accaaactcc
     4681 tatatttcca ctatttataa aaaacgtttg caaatgtcta ataacatttt gaatatgagg
     4741 ccaaataaaa caagttaata atgcaactgg tatcataaca aagaaacaaa ttgcaactac
     4801 aagtgatgag cctctaaata atccaataaa atctggtagt tctttatcat aaaatctatt
     4861 atgaatataa atgacaatac ctgatattaa caaagcacca accataccag tatctaatgt
     4921 tttaatacca gcaatgctta caagtccact tccagcactt atttcagctg cgaaatcaac
     4981 tccaaagctt tttccccaaa aacttaacat agaacctaca aaataattaa aagtcaaata
     5041 cgttgctaaa gcctccatac aagctcttgc ttgttgcttt tttgcaagtg ctattggtaa
     5101 agaaatagca aataataatg gtaattgatt aaataccatc caagctccac tagatattac
     5161 accccaaaat tggtaccaaa tattttctgg tgtagcaagt gaacccataa ttgactgatt
     5221 ttgaaataca attgagaatc caaccattat cccagcaaaa gcaaataata gtgttggtgt
     5281 aaacattgcc cctccaaaac gctgtatttt cttcatcata taaattactc ccctcctcat
     5341 atttttagtt tatctttggc cttagatatc tattatttta acaggttaat aaatatatac
     5401 aatctttagg gtacatttgg agcttattca cagtcaaata agtttttgca catttttatg
     5461 ttcaaattct cataaaaaaa aagaatgact acaatttgca atcaatccct tctgtaatca
     5521 ttctatgcct tttataaata ctatatttaa taaataataa ctcaatcaat ataaaatata
     5581 acattgtcaa tttataacta gggtgcattt gtaaaaatga gatattagtc gctgaaatat
     5641 aaattgattc atcacttaaa tcagtcaatg tattattttt aaactctgta attgaaatta
     5701 ttttagttcc tattaatttt aatcttctag caatattaag tgtattctca ttctcaccac
     5761 ttagggatat aataatcata acatcatttt tactgacaat attgtaaaaa gaatcatcaa
     5821 atgttcttcc ctcaaaatca tatattattt cttgacatga taagaacatt ctctttatct
     5881 gttttgcaac tacattttga atatcacctg aaccataagc gtatattgtt cttgattcat
     5941 aaagaagttt acacaatgca tcataatctt tatttttttg atcttcaaca tacttaatta
     6001 ttgaattaca tgcaatatca aatgactgat tttctatgac atgaaccttt tctgattccc
     6061 agcttaataa tactttaaac tcactgaaac cttttaaatc taatttttta acaaatcttg
     6121 taatagttgc acgagacaca ttacatttca tagcaagttc atttattgac atcttactac
     6181 aatgtttttt atttgcagtt atatatttcc atattaataa atctgtatca ttcaatttat
     6241 tataatttaa aaaaatcatt tcttctaatc tcataaacta ttaccccctt taattaaaaa
     6301 tcgtcataaa tattatacca atattcaaca ttaaattaca gcgtattctt atatttacta
     6361 tttagcccat aaaattgact ataaaaaata ctgctataat tgatgtttaa aaaaatgtag
     6421 ttttaatttt attcttttat ctaataatta atattttcaa gttctagtgc ttttcttata
     6481 caattatcat ctttaaaatc agcagtcctt ttacaatctt ttactttaaa ttctggaata
     6541 gttttaaatt cctcatcaca tattccattc ttatttaaat acatacaact tgccattcta
     6601 actattagac cactattttt taaattaaac aatacagggt ctatacaccc tccatctccg
     6661 ccagtagttt caccaactaa agtcgcaaat ttagtttctt tacaaaacat tgcaaatgac
     6721 tctgatgatg aatatatttt tctatcaaca agtaagtata tattaccctt aaattttgaa
     6781 tcatctgtag attttatagt ataggaagta tcttcaaaat cattaaaatc ttttataatt
     6841 tctttaggtg cattttcctt tacacttgtt ggtaaatttt ctacaggatt taattttata
     6901 tttcttgcat ttgtatattg ttttactatt tcattattat ttctataaat tctataacca
     6961 tttattttga catcattttt tatgagttta gatacgattc cctgccaata actatcactt
     7021 ccacctaaat tacctcttat atcaataatt aaagctttat gtttttctaa agtgtcaata
     7081 taatctccaa ttatttttaa atcattattt atagagccat tctttgatga cattgatggt
     7141 aaatacatat atccaatctg acccttaata acatccttta aaattaattc tttttttaca
     7201 aaaatatcat ctggcatttt tattttaaga ttcatagagt catatctatc tacaactttt
     7261 ttatcattaa gaaaatcata ccaatcatta ttagagtatg atttcttaaa aagttcatat
     7321 cttttcttat tatctattac ttctgtgtgt ttattattta aatcagataa tatagatgac
     7381 atttcttcta taaattcttc atcattttca gtgtttttta ttcgttttgt atattcatcc
     7441 ttatttgcta accaatcaat attattaagc ctcttattta cacctagata tggatatcct
     7501 gtctttacaa cattatacac ataattaaag tcatccacct tttcctcttc agacaactga
     7561 ttcttttgag aataagtaga attacctaat aagattataa atgctaaaat aattactaaa
     7621 aataatactt tctttttcat gtaattctca tccactttca gattttatat tttaatacat
     7681 tgtatcatta ttttattatc acctaaacag ttaaaagaaa ttcttgaaga tatattccac
     7741 tattattctc tttaaaaatt tttatttgta ttttcaaaat tatttcatga aagttataaa
     7801 ataacaatta tattcaaata tctattttac tgctatatcc tgaaggtaaa ttcttatcag
     7861 tgatatacta aaaaagatat gctaaaaaat ttatccatta taatgactta aatttagata
     7921 ctttactgat ttttatttat tagttgagaa agatattgat aattaaaaat attgataact
     7981 atagaaatga ttatttttta tagaaatttt aaggatataa actaattata cttaagtcta
     8041 tatccttaat ttatcatgat tatgagaatt tttacaaata cttatctttg tccgttttag
     8101 aataaaaaca agaacatatc ctgttatttt attcaaacat ccaaatttaa ttactacaca
     8161 attacttatt agaaattgta tctacttcat atatatatct gttaagtata gcttctagca
     8221 tttcttgtct tccagactta ttctttataa ctggcatttg cagtgcataa gattctaact
     8281 ctttaaatcc aaccttacct tctactatat ccttacctat accttcacta aaacttgcat
     8341 atctttcttt agtaaagttt tcaaatacct catcttctaa taatttatga gctattaata
     8401 atccctttgc aaatgtatcc attcctgcaa tataagctag gaataagtct tctacctcaa
     8461 aagatgctct tcttacttta gagtcaaagt taaatcctcc tggtgctatt ccaccttgct
     8521 ttaacacttc atacatagca agtgttgcat catatatatt tgttggaaat tggtctgtat
     8581 cccaacctaa taataggtct ccttgatttg catctatact acctaaaaca ttgtttattc
     8641 ttgctatatt taattcatgt tggaaagtat gtcctgcaag tgttgcatgg tttgcttcta
     8701 tattcatttt gaagtattta tccagattat actttcttaa aaatcctaaa acagtagcag
     8761 tatcaaaatc gtattgatgt ttagtaggct cttttggctt aggctctatt aagaattggc
     8821 cagtgaatcc tatttcctta gcataatcta cagccatttg taagaatctt gcaaagttat
     8881 ccatttcaag ttctgtatta gtgttaagta aagtttcata accttctctt ccaccccaga
     8941 atacaaaatt ttctcctcct aagtacttag ttatttccat agctttttta acctgagctg
     9001 ctgcatatgc atatacatct gcattacatg ttgtagatgc accatgaaca aatcttggat
     9061 ttccaaacat attggcagtt ccccataata actttatacc tgtcttttcc atattaactt
     9121 ttatatactc aactatttca tctaatatct tatttgtctc ttctaaatct cttccttctg
     9181 gtgctatatc tctgtcatga aaacagaaat actcaattcc catcttagac ataaattcaa
     9241 atcctgcatc aactttaatc tttgctatct caattgggtc tgttatatta ttccaaggtc
     9301 tctctactgt gcctactcca aatgggtcat taccctctcc acataaagta tgccaatagc
     9361 tcattgcaaa tcttaagtgt tctttcatag tcttattacc taccacttgt tcaggattgt
     9421 agtatctaaa tgctaattca ttgtcagatt ttactccttc aaattttatc tgtcctattc
     9481 ctttaaatat ttcactcatt tcatgtcctc ctaatatttt acacatataa tatatgtagt
     9541 atgttttctt aatttaaaac tattttctat ctttattttt ctttttaagc taatttaatt
     9601 atttattttt gcattaacta cttcatctaa taacttaaag tcatctttca aagatttgta
     9661 tattctttta tacaatctat gatatatatt gtatgtatct acattttcac ttattggttc
     9721 taatttagtt gaagttttta ttatagcatc acatgctttt tgtatatttt catatattcc
     9781 agctcctact aatgcaagaa ttgcaactcc aagtgctggt ccttcacttg aatttatagt
     9841 atatacatct tgattaaaca tatctgcttg catctgtctc catactttac tttttccacc
     9901 tccacctgag gctcttactt cattaacgtc tatattaaga ttctctatta tatccataca
     9961 gtctttaaga ctatatgaaa caccttccat tattgacctt gcaatttctt ttttagaatg
    10021 gattggagat aatccaaaga acacacctct tgcataaggg tcaagatgag gagttctttc
    10081 tcccatcata tatggtaagt aaagcaatcc attacatcct gttggtactt gacttacttg
    10141 attatttata atctcatata catcttcacc taaagaattt gaaacttcca cttcactttg
    10201 acagaaatta tctttaaacc attttaatga caagccagct ccttgagtaa ctcccataac
    10261 atgccatgta tttggtattg catgacagaa agtatgaact ctaccttctt tatcaatttt
    10321 tggctctttt gtataagcaa atactacacc tgatgtacct atagtagatg aaactactcc
    10381 atctttaact attccatttc ctatagctcc tgctgcttgg tctccagctc ctcctaccac
    10441 tattgttcct tctttaagcc ctgtcaaact tgctacatct ctagtcacat aacctgtaat
    10501 ctcttgtgat tcataaactt tacctaaaag atttttatct atatttaact tttctagtac
    10561 ttcatcgctc caatctcttt ttcttatatc gagcaactgc ataccacttg catctgatac
    10621 ctctgtagca tattcacctg tcaatttgta tcttatataa tcttttggaa gaagtatttt
    10681 attagtattt ttatatatat ctggttcatt gtttctaacc cataatatct ttgatgctgt
    10741 aaatcctgta agtgctggat tagcagttat ttcaatcagt ctttcttcac ctactaaatc
    10801 agttatctcc tcacactctt ttactgttcg ttggtcacac catattatag agtttctcaa
    10861 tgttttacct tcattgtcca gcataactag accatgcatc tgtcctgata atccaattcc
    10921 ttttatacat tcactgctta tatttgaact ttgaactact tctcttatag attcgactac
    10981 agctttccac caatcatttg catcctgctc tgcccaacct gatttctctt gtataagagg
    11041 atattcatat gtacaacttt ttatagtatt tcctagttta tcaaataaaa ctgttttagt
    11101 acctgatgta ccaatatcca cacctaatac atactccaac ttcatccctc cttgaatgcc
    11161 acttcataac tatcgttttc ctatcctaat ttttttatat tttaggtata ttttacttgc
    11221 tttatttttg ttagtatatt aaactaactt atgaactaat aataaaatat ttaattatct
    11281 ttgtcaatgc aaaataacct tttatttttg tgtaaaaagt attacaatat tattttaagg
    11341 aggaatatca aattggttac tgataaatac actattcgag aaatgaatga aagattggta
    11401 cttgaacaaa ttataaaaaa tggtcctatt tctagggcaa gtatagcttc tactatagga
    11461 ttgaataaag caactatatc cgctattacc aaaaaactta ttgatgaatc tctagttcat
    11521 gaaatcggaa ttggaaatag tactcatagt ggcggaagaa aacccatatt attagtattt
    11581 aataaatgtg cagggatttc tttaagtatg gacattggat acgactatat attttcttct
    11641 ctatcttact tagatggaac tattataaat tctaagaaat taacagatat acaagtaagt
    11701 aaagacaatg ttatacaatt gatagatgaa attataaata gttataacat atccaaaata
    11761 gacactcctt ataaggtaat tggtcttact ttggctatac atgggattac ttgtgaaaat
    11821 aaagtattgt ttactccata ttacaatctt aatgagattg acttatatag catccttagc
    11881 aaaaagtatg actttcctat tcatatagaa aatgaagcaa acttaacagc tttagctgag
    11941 aatacttttt caactgtaca taactcacta cttagtctca gtattcacag tggatttggt
    12001 tcaggcatta taataaataa taaattatat agtggcagaa atggtatgag tggagaaatt
    12061 ggtcacacta tcatcatgcc taacggtaaa ctatgtcctt gtggaaatcg tggctgttta
    12121 gaacagtatt gttcagaaaa aaaggtattt gaacagcttt cttctttaga aaatattcct
    12181 aaaatagatt ctgatatagt aaagcaacta tattatgaag ataaccataa tgccaaaaaa
    12241 gttattcatg agttttgtag ttacttaaca atagctataa ataatgctat tacaacttat
    12301 gctcctgaaa taatatattt aaatagccaa ataattagtg atatacctga gatattacag
    12361 attacaaaag atatgttagt tagctctttt aacaaaggaa taaatataga aatttcatca
    12421 ttagggtctg aggcatctct atatggtggc tctgctgtaa atatcaagag ctttttgaat
    12481 atacaaaatt taactttaat taatgaaata taagggttat gactatatac agccataacc
    12541 ctttaaatta tacattctaa aattagattt attatatagt ttatgcaaga ttagctatat
    12601 tttttaaaaa ttgtatatca attaagtatt aacataagta cttcgtttta aatattaata
    12661 taatcttcct actcatcatc agataataaa cttgcatttt gttcaaccat agaaatatta
    12721 tctttaccta ttttctctaa ttttgctgcc aattcctttg tatctaaaaa agctgattca
    12781 ataaccatac ctaaatttag ccctgaaata attttaattc gactgtcatt attggctact
    12841 aataaagcag cattgcatgg agttccacct agtaaatctg ccattataat tatttctgaa
    12901 ctttccttgt acacttctaa agcttttttt aatttttcta ttgttccttc tattccatca
    12961 tcttgtttca tatttacagt aggataatct atagaatccc ctattatcat ttttgcagaa
    13021 tttaagactt cttcagccat attgccatga ctcatcaaaa taatactatt caatttaata
    13081 cacctcttta aatctataag atgtctacaa gataagtttt cttatcatca ggcgtcatta
    13141 tagttgtaat ttcaattcct tcatctaaaa gtcttttaaa tgcttctttc tcttcttcag
    13201 taacactgat attaggtctt agaactgttg tatcttttct acttgacata tttcctacat
    13261 ttatattatg tattttaaat cctgcctcta caaatggaat aaggtccaca ggagacttaa
    13321 caattaataa tacattttgt ccttcatact ttcctgcagt aatatttttt atagcagtct
    13381 cttctgtaat tatagatgac gctatacctg caggtgtagc cattcttaaa acttgttttt
    13441 gaacagaatt gttagctact gcatcattta ctaccattaa tcttgtaaca cccaatttat
    13501 tactccacat agttgcaact tgaccatgga ttaaacggtc atctatacga atatttttaa
    13561 tacctttcat ttccatatct aatatcatcc tttccttatt ttaaaatacc taatgcatat
    13621 aaaattattg aaacaaccat tactcctaaa attaagtata taggttttat attcttttta
    13681 agagcccaat aaacaatcac aactagaatt gcaggaacta acccaggcat aatttggtct
    13741 aatatttctt gacctttcat tgtaaaatca ccttgttgaa agttcaaagc aacattagct
    13801 tttacaactg aaggtattaa tgcacctaca accattaaac ctaaaataga tgtactctca
    13861 gttaaaatct ttaaactttt ttcaattgaa gatattagct tagtacctga tgtataacca
    13921 gcattaaata gtggtatact taataatttc aatgctacac tcactacaat ccacagtaag
    13981 attccaaatg gacttccatc tatcgccata ttagctgcta tagctccaaa aattgtccac
    14041 ggaataacga caaataaact atctcctaaa cctgctactg gtcccatcaa gcctgtttta
    14101 attgaagcaa cagcctcttc agtctcttca cttgataact cctccattgc tacattaata
    14161 cccaaaatat aaggggcaac ccaaggatta gtgttaaaaa attgtaaatg atttaataca
    14221 gcactttgta acttttctgg attatctttg tatactactt ttaaaaaagg tagtactgca
    14281 taacagtatg ccaaggcctg catcttctca taatttgaag aaacagaact agtaaaaaac
    14341 cagcgccata agacactttt tttcaccttt tcatttgatt tatttaatga taccttatca
    14401 ctcatcttcg tccatacctc ctactacagt atattgttgt tcttgatttt ccaaattctt
    14461 tttgtaaatt ataagtgcaa ttgctccacc aattaaagct acacctaata atggtacttt
    14521 catatatact gctaaaacaa aaccaattac taagtaacta aaatactcct tagcaggaag
    14581 atatctaagt aataatccta tccctactgc tggaagtagt cctccagcta ctgttaaacc
    14641 acctgttaac cattcaggtg tatatttcaa aatggtatta attaaagaag gtccaaatat
    14701 tacagataga gcaactggaa tacctgttgt agctgctgtt aatagtactc ctaacatttg
    14761 catataggtt atatttttat aatttccttt tttagctcca tcttctgctt tatgaactag
    14821 ccatatacca atagtatttc taagaacatc taattgtacc atcaataaag caactggaat
    14881 acctatagag attcctacag atgcttcttg cttagtcgta atagttataa atgtggctac
    14941 tatacttgct gtttgataat caggtattga tgctccacca aagttactaa tacctaatga
    15001 taatagctgt aatgtacctc caatatataa ccctgtattt atatctccta agataagacc
    15061 agtaataaaa cctgctgtta ctggttgata tgttccaaac attgttgaat ttttttcata
    15121 gtttataaaa aatccatata gtacgattaa taataattgc cataattgtg gctccattat
    15181 gatttcacct ctcccaaaat attttttagt tctttaaaat tataactgga atcttgcttt
    15241 aggaaaatag gaatttcttc cagtgggcat tcaacttcat aagttttccc accttcataa
    15301 ctaactccac taaatatatt ttcccatgta tgtccttttg gtaaatatac ttttctactt
    15361 ctatctttat aattcattat tggagctacc aaaatttcat ctccaagcat atatgtatta
    15421 tccacctccc aagttttatc atcttcagga aattcataaa ataaagttct cataactggt
    15481 gttccatctt catgcgcttc tttcatcagt ttttttaaat aagtttttaa gctctctcta
    15541 atttttatga attttgtaag aattacttca acttcttcac cataagacca tatttcatta
    15601 ggagctccag ttaccattga gcctccacct ttatttgata atggtttact atgaggcaat
    15661 ctatctccat gcattctcaa aattggtgaa aaagtagcat attggaacca tcttaccata
    15721 agttctctaa attctgggtc tttaggattt cctccatgga aacctccaat atcagtagtc
    15781 caccatggta tacctgccag tcccatattt aaccctgtat ttacttgatt attaaaagct
    15841 tcaaaactag aatcaatgtc accagaccat actaaagctc catacttttg agctcctgcc
    15901 caagctcctc ttacaagagt tacaacagac tctatgtcat tatgtaaacc atcataaatc
    15961 atttttaaat aatcaatagg ataaatatta ccacaactta aaacatttcc ttttttatat
    16021 ctatagttat caaaatcata cacagaatag ccaggttcag ctacatctaa ccaataatag
    16081 tcaatcccaa gttgtttata atttttatct attctatccc aaacatattc tcttgcattt
    16141 tcatttgtca tatctacaaa gactgtattt ccttgaattt gcattgtcat tctaacacca
    16201 cgattaacat tgactaaata gccattttct aaataatcat tgtagttttc tgcatcactt
    16261 tgaactgtag gccatacaga tactattggt tctactgaat actcttcttt caatttttta
    16321 actaattctt taggattttt ccaataatct aagtcaaatt tatattcacc ttgcttaggc
    16381 caatgaaaat agtcaattgc aattgatgaa agcttaattc ctcttttaga atattccttc
    16441 acaacatcta aaacttcttc tgaagttcta tatcttagtt tactttgcca tagtcctaaa
    16501 aggttttcag gcatcatagg aacagttcca gtaacttgag aataattttt atttaactct
    16561 tttgggcttt ctccacaagt aatccaataa tctataaaat ttgtagaaaa catcttccat
    16621 tctgtcatat ttttagcaaa agatactttt ccaattcccg gattattcca taaaagtcca
    16681 taacctagac tagaaatata aaaaggaact gatatttgag aatttctttg ggctaactcc
    16741 aaaacagtat tctttaaatc taaaaattta tgttgatatt gtcccattcc aaaaatcttt
    16801 tcagaaggct cagattcaaa tctagtagtt acttcaaatt ctccactata gcttggtcga
    16861 tattctcttg attttaactt tagagtagag ttaaagtctt tggtaatctc aattgtccct
    16921 acatcttctc caccatcatc atgttttaca gctcttaatc gaatatattc tttcaataat
    16981 atttcatttt tatcattata aaaagtaatt ctatctctat ggtctaagac agcttttatc
    17041 tttccatttt taatgattgc acttccatct tcatttttat taattgtaat atcatcttta
    17101 tttaacttag gtttttcgtt aagagcatag ttttcatcaa caaaattttg gtctacaaac
    17161 gacctaatac gtaaagagtt ttttccccat gcttctattc gcaatagttc attgtcaaat
    17221 cttttttcaa tatagtcttc agatattttt atcacggcta cctcctaaat caatggtata
    17281 atattctatc tttgtgtagc ttaagttaaa taatgtcgtt tagtatcgtt atttataaat
    17341 taggttttat atataattca tttgtacatt aaactaactt accaataata tactttattt
    17401 gactttgttt gtcaatcgct ttccggattt tagtaaaatt ttctaatata ttgctggaaa
    17461 gtcgttctta atatctttta tttatacttt taatatctgt gatgatacct atatacatct
    17521 agttttttta aaacacatac aggaataaca tttgcctatt atgtagataa tatcggactt
    17581 gaaaatatgt atagtgacct tataaataca gataataata tattagatat tgttcaaaac
    17641 aatggatttt ataattataa ataatttatt aaattattta agaaaatata caattgtata
    17701 ccaagtcaaa aacgacaaca aataaataaa actaaaaaag atgttgtctc aaaatataga
    17761 taaatttatt tttcattgct aaaatgatta aaatatattt gatttaatat acttgattta
    17821 atataaaaaa agagtgtctc ataaactaaa aagttcactt ttagacactc ctttatatat
    17881 attatctact tcttaattca tttattacct ctctacattt tctttcaact agtggataca
    17941 tctttataag tactaattac tccacttaaa aatgattcag gtactgtcca tcagtcatat
    18001 ttttctgcca aatataatgg tgtttcataa tgagacaata aatatttata tctctactta
    18061 tcttctctaa gctcgtcaaa tccaactata ggtatattta aattatattc tttaagtagc
    18121 ttttctagct cttctataaa aatacctttc ccatccacca tttgtatatc atttatttta
    18181 tccatcaatt cattgcaacc acttaactca ccaaaccaac gtttagaact acatgtctta
    18241 ttataaccac aacttggact gccatctatt gcaatgatac tttttatatc ataatcattt
    18301 tttaaatatt catcaaactg ccttacatga ggtattaaca tttgcctaca ttgttctcta
    18361 aaaaacaaat tgtcaaactg ttcttttaca tgtccccacc tatttattcc atacataatc
    18421 atttctgggc atggtagttg aattattcca taccctttat ttattaaatc tatcgctata
    18481 ttttgtgctc ccttaaattc tgacaatccc tctactttag aattacaatt taatatacaa
    18541 tgacatacta ctacaatctc tctatttctc ttcataataa tctccttagt tattcttaat
    18601 tttaatgata ctacatattt tgataattat attatttatt tgttctatat ttccaatatt
    18661 ctatatagaa atatacaatt agtaatcttt tataatctat actatgataa atgtatatat
    18721 ttttttagga ggtattataa ttggatacta aaaaagtcac attttcttca atgtgcatag
    18781 ttattaatat tgtcttaggt atggttatat ctatgataaa tataccatta ttatttttag
    18841 atacaattgg tactgtactt ggggctgtcg tattaggtcc tttttggagt gctcttattg
    18901 gtgggtgtac aaacttagtt ttaggtgtta tatcaggtcc tacaaatata ccttttgccc
    18961 ttgtaaatat tgttcttggt cttattgttg gatatatttc taagaaaaaa ggttttggtt
    19021 ataaagaagc tattattaca ggagtaattt tatctattgt ttgtccttta attggtactc
    19081 ctatttcagt tttattgttt ggtggtttaa gtggaagtgg tgctgattta ttggttggtt
    19141 ttttagttca gtctggtcag aagatattta ctgctgcgtt ctttccaagg attcttagta
    19201 atatagtaga caaacctttg tcttgtatta tggtggtata ttttataagt aaaatgccta
    19261 aaggttttat aaaacaatat agtaaaaata cttctagttc atattaataa atcatttatt
    19321 atgtaagatt tattactctt taaaatgcta tatactcatt tttatataac atttttatta
    19381 ataatttaat tagatagtat ttgtattatt ttaattaaac gtaacctctt gatataaatt
    19441 tgagctataa atctatatca agaggtgcta ttttattttt aatataatta atattctatt
    19501 acgcaaaaaa tacatatatt tcattatttt atggaaaata ttacttcatt taactctata
    19561 tcaaactcat taagtaaaaa tctaattata tttaatttag cctctgtatt taaatttgtt
    19621 tctaaatata tattttctga tattttaata ccttttctta atttatatgc atctctagac
    19681 ttaatattat ctataaaatc tcttttataa gtcttgtcta caatactgtt aaaccttaca
    19741 gaatccaaat catataaagt aagagcaact tgttcataaa attctgtcca atttttagcc
    19801 ttatatgact ctcctaatat actaaatgat actatacttt catttgtaaa attaacatca
    19861 tcatcctcta acgtaaatat attttcactg ttacttggag gttcatatgt aacacttgga
    19921 tatttccaaa tttctacagc tctatctagt aatatcttag ttctattttt tatttcttct
    19981 tcattccatt tatctataga tgaaatatat ttatttagat aaagcctact atctttaaat
    20041 ccatcttcca tttctttctt ttcttcaaat gttttattac ttagttttga attatatcct
    20101 gtcaaagtta aatttccaat tgtatgtaaa tatttatcat gtatctcctt atagttatct
    20161 cctagtgatt ccttccattt atttgttaat gtctgtggca ttatatgctc tatatttagc
    20221 atattattat tgattaaatt ttctaaatca acaatttctt tattattata attctctaac
    20281 ctctcaagta tatataactt attctttgac ttagtattat atatatcttt agtttcaaaa
    20341 gcatttgaaa attcactgtc agtaggaaat ctttgagatg atttcttatt tataaaaata
    20401 tatcttaata tattagaata gttttcttta taatcactaa attttttaat ttcccttcct
    20461 aagttcataa atactttatt cagtgcatta ggaggtacat cacatactat tcttcttaat
    20521 ataaaacatt ctactaaatt aagggattct acaagtactt ttttatttat tataccttca
    20581 ttataatcat caaataattc taatataaac ggatatgata caaatatttc aagtttgttt
    20641 atccttttca aaactttgtt tacatcatta tcatcagtac atgaataaga tatctctcta
    20701 taatagttag aaaatttaag taaatctttt aataaaattt ctatatctat accattatct
    20761 gatacatacc ttttaaaact aaaatatact ttatttttat tcggtatact tctctccttt
    20821 atagtcaaat agtctcttat aaaactactt acgttgctac ttgtattttt ttcaatttta
    20881 taccaataat tattataaaa ttcctcttgt aacttagagc ttctacccat taacacaaag
    20941 tttcttactc tatcagcttc acttaaatct aagccagttg aatttagact ttcaaagatt
    21001 aattgagggt catcttcacc attttttaac tctatttcta ctatagttaa tttctgtata
    21061 gcatcaaaca aatcatctat tgatatatta tcttctttta ttctattata aaaatataaa
    21121 taatttgaaa ctatattaga atttctatct gtattcattt cttcttcaaa tagttcatag
    21181 tacgcttttc tatcttctgc tattggtttt aactttattt ttccatcttt atctcttgag
    21241 tgcttgttta taagataaca ctccttaatc tgttcttctg ttgtaataat tccttttgat
    21301 tccccaaact cttttattat ttgacacatg gcaatcaata atattgacac agtagtcact
    21361 ctttgttgtc catctattat taaatattct tttcccatac tatatataga tacaactgac
    21421 cctaagaaat gagttctaaa tccagaatct attatatcct ctaaatcatc aaacaatctt
    21481 ttacattgtt ctttcttcca gttataattt ctttgatata caggtactac aaaacttttg
    21541 tttgacccct ctaaataact aagaaattca atttctcctg ctttcatatt aactccccct
    21601 ataagttaaa taaattccat tcataactcc atgtatctat atattatatc aaaattttga
    21661 ctcataaatg tatatgaaag ccttattata taccttttta tacctgtttt tattttatta
    21721 aagtaaatac atgattattc tataaaatat acaaatactt aattttaaaa attattattt
    21781 aatcttcttc atgagtaatt catagttatt tatcaattaa aaagagatat tgcataatta
    21841 ttcaatacct ctctttgtat atttacatta tccatatcta gttatctatt tcaacccaat
    21901 attagactac ctactaataa atttattctc tacatcatta acaataattt tgcactaaat
    21961 aacatcatta gcctatctct gatgcatttt ctttaatttt atttatagtt ttaatcaatt
    22021 tatttctctc ttcaatatga ttttcaaata aatcaattat acttccaaca gttctaaatg
    22081 ggtcttccat caacactttg ttatcctcta taaatccatt cttgactaca taatcgacta
    22141 taagtttaac aaaatgtatt tgcttagtat taaagctctt attatttaaa aactctgaaa
    22201 aagcttcatt tgcagcttct ctatccaatc ccactagtct tctcactaat tggcttactg
    22261 gagtatctcc aaactccttc ttataatcat cacaattacc taactgtttt aagagtattt
    22321 cctccaacgt ttcaacatct tgctttgtta tctttttatt atttcttaat ttaaatattg
    22381 ctaattcatc tttatggcta tttaaataat actctacctt ctttttataa ttcttaagat
    22441 tgtttgcatt atatacagaa tcatttctat cttctgctac aatcatatct tcaaaacttg
    22501 tataatatat cttttgacta gacttttcaa gatacttaat aagctctctt aatgatatac
    22561 gtacttcttc tacctcaaat atatctgaat cttcccaaaa atcctctgtc attgcttttt
    22621 caatagtata tttttgttgc tgaatctgtg gtatagtccc aagttttgaa agtttttctg
    22681 ctgtagccat tacatgcctt atacctttac ttgcattatt attttgtaag tatgcaagtt
    22741 gtatattata cataactaca tcaaatcttt tagccaattc atcatcacta tatgaagtta
    22801 tgagtggtga tatatattct cttatctcat tttgtgctac tgctccaata ttgctccaaa
    22861 cattttcatt tttatactta tgtacataac ttaaattcat cctaactata taactatcct
    22921 catttaaagc ttttacagaa gttataagtt cttctaacaa ttcttttcta agttctgcat
    22981 actcaccttc tatatattta atatcttgaa gttctttaac catacttacc tttatattaa
    23041 ataatttttc agtaagtgtt tctgttttat ttccctcaaa tcctttagga ttaaatttaa
    23101 aaaattcaaa attattacaa aaatcaaata ttaagaatct ttccttatcc atatcaacac
    23161 ctaataaatc tggacataat ctagttcctc tacctatcat ttgccaaaac ttagtcttac
    23221 ttctcacttt cttgaaaaaa acaagattta gtatttcagg tatgtcaatt cctgtatcaa
    23281 gcatatctac tgaaactgct atttgaggta atttattctt atcagaaaaa tcatctatta
    23341 tagaatctac ataatttata ctatagtcaa ctgcttttac aaagttccca ccatactttg
    23401 gatacagttt attaaatctt tcaactattg ccctagcatg ctttgtattc tttgcaaaaa
    23461 ttatagtctt accaatcttt tcttctcctt ctattttcaa cccctctgtc attagcttat
    23521 ttaaaactaa atctattgtg tcagaattaa atagccactc atttactgca ttattcccta
    23581 tttcgtctcc aatactctca tcatcattaa atgtattttc atattcttcc ttctcttcat
    23641 cagaaagctc atcatactta attccatctt ccataatctt agtcttaaac tcaatactag
    23701 tataatctac taaatatcca tcctcgactg ccttattata ctcataagca tatgtaggta
    23761 ctccattttc catgtcaaaa actgaataag tatttttatc tatctcatcc tttggtgtag
    23821 cagtaagacc cattaagtaa gaatcaaaat aatcaaagat tgacttatac tttttataaa
    23881 tacttctatg cgattcatct attataatta aatcaaaatg accaggtgta aacaatctct
    23941 ttccatcctt agacttcgta tcatcaattg cattcatcat tgttggatat gtagaaaata
    24001 tcatcctagc atcttctggg ctgtctttgc tatccaataa attacataac gccaagttag
    24061 gtaatagctt agtaaaactt tttttagctt gctttaccaa tgcttttcta tctgctagaa
    24121 ataatatatt tttaatccaa ttatgtcttg aaagtacatc aactatagat atagcaattc
    24181 ttgtttttcc tgtaccagta gcacatacca aaagagtttt gcgttgctta ttttcaagag
    24241 cctcacatac agccctaata gcttcttttt gataatatct attggatatt tcatcattta
    24301 ttgttacaga acttaaagac ttcttactct ttcttctatc tatcataagt tgtaattctg
    24361 attttttata aaatccataa actttcctat ctgaatagtc atcccaaata tacatatcaa
    24421 aaccattagt caaaaatatt accggtcttt gactatatct cttttccaaa caatctgcat
    24481 ataatttagc ttgttgttga ccaattttcg ggtctttact cgttcttttc gcctcaacta
    24541 ctgctaatgg cttaccattt tcaccataaa gaacataatc tacatatccc acaccacttt
    24601 cattaggcat accttgtact tctatttctt cccatatatc ttttccaaat tcccaacctg
    24661 caagctttaa ttctatattt atatatcttt ttcttgtctc aaattcgctt acttcgtcta
    24721 tcttgaaatc atagtttaca gtattaactt ttctcttttc agttagtgac tttcttaatt
    24781 cctcattttc ttttattact tcttcaagct ttttatcttt tgaacttaat ctctcataaa
    24841 gatttttaag ttcgtctggt ctcgtccttt tctcttcccc atgaagtaat aaatcttcat
    24901 taaagtcttc tgctgtatat tcatctgaat aacaatagtc tatccaacta acaaattgat
    24961 gcaaattgtt aagtgaaagt attgcttctc ctctctctat gttcgcacta gtatgtacag
    25021 ataaattacc taatttaact atatatttta ataaaggtaa catatcatag tctataagtt
    25081 ctataaaact attattatga atcaacgtac taagattatc ttgataaggc aatactaaat
    25141 cactatcatt agcatatagc cattttactg caagctctaa agctcttctt gttatagttg
    25201 cacaagtaga tgggctaact agtatacttt tttctgcttc taagcaagca gtattaaaac
    25261 tattgaaatt tttcttcttt tgtaaaaaat caaaattacc caaggctttt atcccccttt
    25321 tgtcccttag ttaaaataaa tctctctaaa aactatttct tacagctgtt tcttatacta
    25381 acaaatactt cttcattttc tgtaaacaat tcgtacatat cttcaaactg tggtatatca
    25441 tatccatgag aatcatcatt tctcaatttt ctaagtgttt ctataactat agaagaattt
    25501 ttaggtaata aattgtgata ctcacaagct aaaaggtagt cataaaagtt tttagatttt
    25561 atgtttaaat caattgattt ataatacaac attgcttttg ttaattctag aaatgatacc
    25621 atatagcttt taaagccttc ttttatgtat ctagcccata actcaggcat ttcttcctta
    25681 tcatataaga ttttgaagtt ttgcaggtca tacaagcaag aaccaaaatc cctatttact
    25741 tcttctattg agttccaaga taatttgttt ctaattacca tacatgtccc tccaatctaa
    25801 gatatctatt acatcactgt tttcaaaata gaatttattt atataatcct taaaatcttt
    25861 agatttataa ataacttcac cttctaaaat agctttttta agtgctattg tataattatc
    25921 tgtaacaatt tttaggtcta catcaatgtc taatatattt cttagagctt ctgtcttagt
    25981 tgcaagttct gtaattggta cttttttgat gggaatccaa gctatgtcta tatcactttc
    26041 tgatgtatgt ttatctgttc cataactacc aaatattatg attgctagag tattttcttt
    26101 tggaaataca tttattattg agtttttaat ctcatttggt atatttctca tttaatcacc
    26161 tcttgtttat taggtaatat tgcttaattg aatttatatc cataatcttt taatctattt
    26221 atacatattt ctctttcttc atcagtaaac aactctttat acttttcttt taatactaat
    26281 acttctaatg ataaatctaa tctcttacac tcccatagcc ttgtaaatcc ttcagtagct
    26341 ccttctttat tgattaattc tttagcagct aataaggctc ctttgttatt tatcagttgt
    26401 aaaaatcttg ttggcttata gttacattgt aaatcagctt ctttatagat atttaccatg
    26461 ttatggtata aatctagctc tatttgattc atagatttta ttcccccatt ttaataattg
    26521 tattttagtt gaataactat cctttaaaag ctttttgcat taatgagtta aagttgtctt
    26581 ctagttcttt tagacttgtt tttattccta ctttcaattt gtctacttga ttaacaaact
    26641 cttcaaactt attttgaagt tctattgatg gtactggtat taatattttt tgaagttctt
    26701 tgcttctaat tccttgtgca gagctaccag ttttatattt atctatttct accctaaaag
    26761 cttttgtttg catatattgt gctaaaaaag cattatttaa aattttttta tctccctgaa
    26821 ttgttataat cctttgaccc atagcaaact tttttaaatc ctttggtatc ctacatacat
    26881 ttccaaatgt atgaccttct gtaacaaaaa gtacatctcc agctactgga aaacctcttt
    26941 tcatccaaga attataggtg ttttcagata tatattcatt aatatattta aatacaccat
    27001 tccctacaga ttttgcattt attattctaa ttccattctc tgaaagaatt ggagttttac
    27061 cacgataatc aataaaattt gtacaatctt tcaataatac aaacttttgt tccttaaaat
    27121 ttccaaacat ttcaataaat cttgatttaa ctaattcatc caatgcttct atttgctctt
    27181 ttcttttatc tattaactct tgagctttat ctaaaacttt tgatatatct ttttgagctt
    27241 ccatttcagg taaatctact tttaaatttt ttaaatcatt aactgaaaaa cttgcttgat
    27301 taactgattt ttttattatc cttggtaact gtcttctaaa ttcattacta ttaaaaaaat
    27361 aatttaaata ctttggataa caaacttctt tatctggtcg taaacataaa agattcattc
    27421 catgtataat ttttttattt atatcttcat atattgcact tttccctaaa tgtttttcac
    27481 tattaatatg tgacattagt atatctccat ttttcaataa atagtcttct aattttccta
    27541 actcttttat gtcagcatat cccattttat tagtatcaat ataagagttt gctatagttt
    27601 ctattcttgt aattggatat ccaaattttg tatcaaattg tttaatacta gccccatttc
    27661 taataaattc aaaaacttca ttcaatctat attccatact ctacacctca agcattcttt
    27721 ctaattcctc taatccatct acgatttcct tctctaactc cctaactcta cctataataa
    27781 cactaggagc atcataaact acttcctcat acactacctc tttatactta ttaatagata
    27841 aatcataccc attctctctt atctcttcca catcaacaaa aaagctttgc tctgttcttt
    27901 ttctatctac ttcaccatca agattatcaa atctcttaat aatatcctct atatcactat
    27961 cctttatctc atttctctta tcatccaaag aataaccatc agctttcata tcatagaacc
    28021 ataccttatc agttccacct gttcctgttt tagtaaatat cattatagct gtagatactc
    28081 ctgcataagg cttaaacact ccacttggca ttgatattat agcttccaat ttatgattat
    28141 caactatttc ttttcttatc gatttatgtc cacctgttga accaaacaat actccatctg
    28201 gcactataca tgcgcatctt ccaccaattt ttaaaactct taaaaaaagt gccaagaata
    28261 ataactctgt tttctttgtc ttagtcactt ttaataaatc tgctgacact gcttcataat
    28321 ctaaacttcc cttaaaagga ggatttgcta acaccaatgt aaacttatct ttatctgtat
    28381 taacctccga taaagaatcc ttatactcta tattaggatt gtcaacgcca tgcaacatca
    28441 tattcatagc acctattcta agcatagttc tatccatatc aaatccatag aacataccat
    28501 tattaaaatg ctccttcagc ccttgcacta agaaaagact tgaatgatta tcccttaagt
    28561 attgttgtga tgatactaaa aaacctgccg aacctgctgc cgggtctact ataatatctt
    28621 ctggtgttgg tttaataagt cttactatca tatctattat gtgtcttgga gtcctaaatt
    28681 gaccattagt acctgctgta gccactttgg ataataaata ctcatacaaa tctccctttg
    28741 tatctctatc cttacttaat tctaaattac taataccatc aactatttta gataacataa
    28801 gaggcgtagg aattttaaat attgcatctc ccatgtactt tgcataagct gattctttat
    28861 ttccatgtaa tttttttatg aaagggaaca cttcattttg tactatttca tacatttttt
    28921 ctgaatttcc ttcattagaa aacttactcc accttaaatg ttgatgttca tcatcaaata
    28981 tcttttcaaa agaaacaccc aaaagagttg cttctgcttc attttttgtt tctacttcat
    29041 ccaatccttt aataaataaa agatatgtaa attgttctat aacttctaat ggattagtta
    29101 atccaccagt ccaaaaagtc tcccaaatct tgtccacttt actccttaat tctcctgtaa
    29161 tcatatatga ctttccctcc agtgttcata aaataattta aatatatatt ttagtcgtac
    29221 gccttaatag ttagtgtctt atgttaaatc caagttttta ctacacaatt attaaattat
    29281 ttttcctatt tacatatttt agctaaaaaa ctaatgcaat actcttattt tatgattatt
    29341 atatatacca tacaaaatta ttttatcata tatccatcat agaagtcatc tacctggata
    29401 actcttacca tattataact ttttaatatt aatttaaact tagaaagaaa ttttttattt
    29461 aattatatca tcttccttat ttcaaatttc tcaattacaa tcttaatcaa aaaataaaat
    29521 aagatgctgt ctcaaaatag atataatctt cttttttatt gtcggaatga tgaaaatata
    29581 tttaatttca tacaaaaaag agtgcctcat gaactaaaag ttcattttga gacacccctt
    29641 aatttaatct tacttattct ttccctttat tattaacact tcactatctc tattgctttt
    29701 cctacacatc cacaaacttc catcctactc ttaacaaaat ctttaactga ctctaaacct
    29761 tttttaccat attttttagg gtcaattacc tctgggtcag aattaagcac atccttaacc
    29821 ccattgctat aagcaatcct taattcagtt gcataattaa ccttgcaaat ccctcttttt
    29881 atagactcct taataacctc atctggtatt ccagacccac catgtaatac taatggaact
    29941 gatacaacct ctctaatttc agataatcta tctaaatcaa gttttggctc tcccttatat
    30001 agcccatgtg ccgtacctat tgctactgct aaagatgata cccctgttct ctctacaaac
    30061 tcttttgctt ctaatgggtc tgtatatgct ccaccatcac caccatctaa atcgtcttcc
    30121 ttacctccaa ctttacctaa ttcagcttca acaggtatat ctgaaggcat acatgcatct
    30181 acaacagatt tagatattga aatattatct tcataacttt catgagaacc atcaatcata
    30241 atagaagtat atccaactct aagtgcctgc atagctagtc caaagcttga accatggtct
    30301 aagtgcattg ctactggaac acttgccttc tctgatgcta cctttacatt cgctaaataa
    30361 taatctagtc ctgcatactt tattgttgaa ggtgttgttt gcaatattac tggtgattta
    30421 agttcttcag cagcctctat tactgccata accatctcca tattttcaac attaaatgca
    30481 cctactgcat aatgcccttc ttgtgcatct aataatattt gtttagttgt cactaatgcc
    30541 ataatttctc ctcctatatg tttatactga tttaatttct tcgttattta attttgatac
    30601 tatttctcta cttgttttgc tatttaataa ctcatttaaa aattcttcat tcattaattt
    30661 tgaagatagt tgagataatg tttttaagtg taaattatca ccattatctg tagctgctat
    30721 cataaatata atatgtgcca agcttccatc ttctgattca aagtcaaacc cttcttttga
    30781 tagacctact gctacacgtg gtacctttac tgcatctgtt tttgcatgtg gtatcgctat
    30841 ccccatacca aaacctgtag atgatatttc ttctctttta aggatttctt ctttaaactt
    30901 ctttttatct aaaagaacac tagatttatc aagtattcca atcatttcat caattacatc
    30961 tgttttattt tttcccttaa catctaaaat tactgtttct tcgctatata aagagatatt
    31021 attagatacg ttttccgatt ctgcactttc atttttatgt tcatcttttg ttacatttgt
    31081 attttctata gtatttttct catttactac tttaggtgta accatcatat aaagtacagc
    31141 acctactaat gaacctacaa atatacaccc tacccataaa agtggcttat tgactaatcc
    31201 tagaaccaaa aaccctccat gtggagctgg tacttctatt ttcattatat aagttaaaat
    31261 tgatgatatt gatgatgcaa tcataagtac tggcaacact tttaatggat tttttgctgc
    31321 aaaaggtatt gccccctctg ttatatgagt actacctagt atataattga ttaatcctgc
    31381 tgctctatct tcttctgtaa atctattttt aaataaagta gatgctattg ctattaccaa
    31441 tggtggtgtt atacaagctg cagatacacc tgccataaat aaataatttc cctgtcctag
    31501 aagcatagtt ccagttacat atgctgcttt atttactgga cctcccatat caaatgctga
    31561 catacatcct attactattc ccaaaattat agggcttgaa ttttgtaacc ccgatagaaa
    31621 gttcatcata gcattgttaa gtgctgaaca tggcccacca agtaacaaca ttgctacacc
    31681 cacaagacct acgctgacaa taggaattat aaaaatcgat ttaagacctt ctaattgtcg
    31741 tggtaatttt cttaacaaat gtacaaatag tttaactaag taacctgcta aaaatcctga
    31801 tatgattcca cctaaaaacc ccgaacctgt atcaaatgat atcattcctc caacaagtcc
    31861 tgccaacata ccagctcttc ccgatataga ttgagctata aatgctgcca atacaggaac
    31921 catcaagttc atagaatatc caccaacaga ttttaatgta gctgctattt gattatattg
    31981 ttctgaattt gggtcaaatg aataaatccc ccataaaaat gatatagcag taagtactcc
    32041 acctgctact actaaaggta acatgtgaga tacaccattc attaagtctt tatacaactt
    32101 ttgaccaaac gataaatttc cttcttctgc aattttactg cttgataagt ttccttttct
    32161 aatagctact tttccatcaa tacatctttg tataagttca ttagctttat gtataccttc
    32221 tttgacaggt acttctatta ctggctttcc attgaatctg tccatatcaa catttttatc
    32281 acaagcaact attattgcat ctgccatttc gatatctttt gctgttaact tattttctac
    32341 acctatagct ccattcgttt caacttttat gtcacaccct aattccctgg ctgaattttt
    32401 taatgcttct tctgccataa aagtatgagc tattccagtt ggacaacctg ttacccctag
    32461 aatcattttc tttcccattt ttataccacc tttctgactc ttatattttt tatataatct
    32521 tccacattct ccaaattacc tataccatta ctttcagcca cacttgctcc tgttgctgct
    32581 gaccttttta atgcttcttc aatatgttct ggattttcca accatatact taaaaaagca
    32641 gctaatgcag aatcaccagc acatgcagag ctgactactg taactggttg agcactagca
    32701 taataaattg attttccatt ataaaaataa gaaccttttt ctcctaaagt tagcaatata
    32761 ttttgagcac cttttaaatg tagtaattta agtacatcct taatatcttc ttcatctctt
    32821 acaataattc caaatatatc tttgatttct tcatcatttg gttttatcaa atatggatta
    32881 tactgtagta actcctttaa ttttggtgaa cttatatcga gtattgtctt tatactttta
    32941 ttttcacaaa ttttaaatat atcctcatag taattatcat caataccagg aggtagactt
    33001 ccacttattg ataagtaact tatatcttct aatgactgta tcttatctag catatctagt
    33061 ttttgttttt cgtttacata tgacccagag tttacaaatt taaattcatc acttccatca
    33121 tttaaaaata tatttatacg agttgtatct tctacccaag taggcaatac gtcaaatcct
    33181 ctcttttcgc tttcttcaac tatatatttt cctgaaaatc ctccaaaaaa tcctaatatc
    33241 ttagattcta taccataatg acctagtaca aaagttacat ttaatccctt tccattagga
    33301 gaatatacag catttgatgt acgatttact aattttctct ttatcccatt agtagatata
    33361 ttcatatcta ttgcaggatt tgtagttaat gtatatatca ttgtcttccc ccttgcttgt
    33421 gctgtgtatg ttttcattat aataaaaaag tctatgaaaa tcttttcaca aatagaaaat
    33481 cgattttcat agacttttca atttaatttt cagaattatt atatctgacc atataatcta
    33541 taattatcct agatataata tacaagggca atctggaaga tacttcatat tcagaaattg
    33601 atatatgttc atgtttgtat cctacaatat ataaatccga atactttata agttttgcac
    33661 tttcactaca acagcaagtt ataaccttag ctccaactaa attggcattc tgtgctgatt
    33721 ctacaagctc tattgtattt ccattcaatg aaaatataat tataagttcg tcttttttta
    33781 ttgatttaga ttttattttc attatgttgg ggtcatttat aaaaacaaca ttaaaatcaa
    33841 gtaattgcaa tttaagacta aactcttttg ctacatattc agtaagccct cttgctaaaa
    33901 tatatatctt actagattta tttacagttt ttattatatt gattagtgta gttaaagata
    33961 tttgttctat aactctctgt gcttctataa aggatttatt tattatatcc cccatatttt
    34021 gtatatcatc attttcatct tttactgtta atctatacct aagttcattg aatccattta
    34081 aaccacattt tctaattgct cttgaaacgg ttgctggaga tgaatatgtt tcatgagcaa
    34141 tctctactat agataattct ggtaatattg attcattttc atttataaat ttaattattt
    34201 caagttccgt cttggttaga ttttcagaat tacttttgtt tagctcaatt atcatatgtt
    34261 atctcccctt atataagttt tatttgtcta aatttatcga gtaatataat atattacctc
    34321 ttaactactt atttttatat acaattaaga tttagtcaat gtctatatat gtaaatttat
    34381 aatataataa ttttttgctt aaagtttatt atgttatctt atagcatttt aaaataaaaa
    34441 agaattgtac ctctaccaaa atttggatga agtgcaatag atattcctta tactgatatg
    34501 tttatgatta aaagtataaa tataaatttc gctatgaatc atataattaa taaatcattt
    34561 tatttacaat tataaccccc cttataaaac tatattaata atatatacag tatttataag
    34621 gggggttgtt tatatttaaa aactatttac ttttctttta attcttctcc attagttctt
    34681 attacatttt gataccaata aaaactatct tttttataac gttttttact tccatttcca
    34741 ttgttatcta tatctacata tataaatcca tatctttttt ccatttcttg agatgaacaa
    34801 cttactatat ctattggtga ccacatacaa taagctaata tttcggttcc atcagctata
    34861 gcttcaccta tttgttctat atgttttcct aaataatcta ttctgtaact atcatgaact
    34921 tttccatctt caaatttatc atgcattcca aatccatttt cagctatcat tattggcttt
    34981 tggtatctat cataatattg agataaagta ttgtataatc cttttgggtc aattgcccac
    35041 ccccaaggat ttgcttttaa atatggattc tttatattgt cagttggatt catggtgttt
    35101 ttacttgctg atactgttgt agaataatag tatgataaag ctagaaaatc catagtattt
    35161 tcttttaaga ttttatcatc accttcctcc ataactatat ttatgttatt ttctttgaaa
    35221 aatctcttaa tatagactgg atactctccc ctaaaactta catcagtgaa aaaatattgt
    35281 agcctatttc tttttaaagc aaatactaca ttttcagggt cacaatcttc tggataagat
    35341 gtacaatctg ccatcatcat acctatcatc atatctgaat ttatttcttt tccaagcttc
    35401 ttagtcaaag ctgtagctat gaattgatga tgaatagctt gatatctagt ctcttctaca
    35461 ttatctactt ggtctacaca aaatgcaact gaattaaatg attcataatg tattaaattt
    35521 atttgattta taactatcca atatttaact ttatttttat atctatttag tattaattct
    35581 gcatatctaa caaagaaatc taccactttt ctattagacc atcctttata ttttaatact
    35641 aaattcaaag gagtctcata gtgaagtagt gttacaatag gttccatacc attatctatt
    35701 acttcattta taagattatc ataaaacttt aatccctctt cattaggctc taaatcatct
    35761 ccatttggaa atattctagc ccaatttatt gaaaatctaa aacactttaa ccctagctct
    35821 ttcaaaagct ttaaatcttc tttgtatgta tgataaaagt ctattccact acgcttagga
    35881 taatatccat tattatcttt catagcaaac tttattcttt ctatagtcat atcagactca
    35941 taaggtttag atatatctct atctttatca tacatatgta catcagctaa acaccaacct
    36001 ttgccacctt cattccatgc accttctaat tgattagctg ctacagctcc tccccataaa
    36061 aaacctttag gaaacttacc caatttaatc actccttatt ttatttattt aaatcattta
    36121 ctattattta ccttatattc tatagacttt actattccta ctaaagacat agttatattt
    36181 aactcgctga atatggtcat aagagtatct tgagcatgtg caaataacag cgaatgtgct
    36241 cttttctctc caccagcttc cccttgtata atcttggttt gagctctatg tgcttctgtc
    36301 ataaaccctt ttgctttagc tagttttaaa tcagcatttc tataatcaaa cttttccaaa
    36361 tcattaagag catgtttaat ttctgttcta gcctcacctg cacgaagtat tatttgcatt
    36421 gccacctcta ctaattcttc atctattata tgttcttcaa ttgtcatatt tataatttcc
    36481 tttcaatttc taaatttaaa cctcttggct ctctaatttt atctcttctt tctcataagc
    36541 tttaaaaaat ggataccata tcataaatag caatactata tttattgcta aaacaataag
    36601 acctctaaca tcttgattta ccgtaaaagt agatatacca aaaggaacat accataaatt
    36661 aaacacctta cttggaattg tcacaaatcc catactcatt gataagtaag tagttattga
    36721 tattactact gttcctatcc acataggtaa cattaaaaat gggttccatg ccactggagc
    36781 tccaaatatt actggttcat ttatattcat tatagaaggg acaatacatg ctcttcctat
    36841 tgcttttatt cttccaactc tggataaaca catcattata actaatggta atgtagcacc
    36901 caaccctcct aaagttatcc aacctgtttg aataacttcg taaacatata tattagttgc
    36961 tactcctcct gatgctactg ctgctgcatt agctgcaatt gcaccaagtt gaattgaata
    37021 agttatagga gatagtaccc acccacttat tcctaaagaa tatataaata ctactaaaaa
    37081 gtttaagagt acaaatccag gtaatgtctg tgctatatct gatactggtt taaatactct
    37141 aactattatt tcaaacatgt caaagttgag tccataaatt aatccccagc ctacaaacat
    37201 tatcactgtt ataggtaaca tattatcaaa ccacttgctt acaaaatccg gaagtgctga
    37261 atcttctccg aaaaatgaaa aagaaccaaa taaggacatt attaatccag agaataatcc
    37321 tgcaactagc gatacaagca ttccttctcc tccaaacctg ttgaagttaa atatagctcc
    37381 ttcattcgta atctctggac gaatcatcat taacattaat ccagcacctg caagaccagc
    37441 gactacactc atactttcaa atttcttatt cttcattatt tccataggca ataaaaatgc
    37501 tataaataat cctaaaagtc caaatgtata ttgatttatt ggacttaaat caggtaaaaa
    37561 gcttatgtaa ttcttcaaga cagaaactat agttactaat gagcctacaa ataccattgg
    37621 caaaactttc attatagttg attgaactga ttgtacccat atattcttag tcatattatt
    37681 tacaacagga gtaaattttt cacttaaaaa atctataaat ttattcataa acactctccc
    37741 cataaatatt ttatttgttt gatattagtt ctagtgcttc ttccaaagcc tttgccccat
    37801 ctagtcttcc atatgcagtt ttagatatac atgctactgg aacgttatat tcattagcct
    37861 tttgttgaat ttcttccttc atataatcta aatgtggtcc tagtaataaa caatctattt
    37921 ctgataaata cttatctatc tctgactcac ttctcgcttt tatatctgct tctatacctt
    37981 ttttctttgc actctttctc atactagttg ccataaaacc tgtacttgct cctgaaccac
    38041 acgccaaaag cactcttata tttttcataa tgatacctcc aatattttta tccatcaatt
    38101 tatttcttaa tgaacttttt attttattat gtttatattg tacttaccaa ataagttcat
    38161 ttcacataaa tatatttcct aataatagga aatcagttac tcttaattaa acatattaat
    38221 atagtataat gtatcttata atacgtacat tcaattatat aattatcata tcatccagat
    38281 tttattttaa aactatgcga gggaatctaa tgaaaacatc taaaaaagaa ctatttttaa
    38341 atttcataaa aacacaacat gattggatag attcatctac attggctaat tatcttaatg
    38401 tctcaacgcg ttcaattaga aaatatgtaa acgaaattaa ttccaatggt gaatttatat
    38461 tatcctctaa aaaaggatat aaagtaaatc tcaataataa ttgtcaaacc aaggttgata
    38521 gttcagaaaa tatatcacct gataacaggt taaatttaat tttaaaagaa cttatagtta
    38581 atagtaatgg aattaatata tttgatttaa gtgaagactt gtttgttagt ccagctacta
    38641 ttgaaggaga tatagtcaaa gctaataaat ttataggaag ttataattta aagataaagc
    38701 aatcgaaatt tttattgaaa ctaattggaa atgagtctgc aaagcgcaaa ttaatgagct
    38761 ctataatatt taaagaaacg ggaagtgatt ttttaagctt atttgatgta caaaaaatat
    38821 atcaagagta taatttgacc aaactgaaag aaaatataat atatatatta aaaaaataca
    38881 atttgtttat aaatgagtat gctataaata acatacttct tcatttaatg ataactatag
    38941 acagaataaa aaagaataac tacatagaat ctgtcgaagt agtaaactac atagataata
    39001 ataatgatat aagcatttca agagatatat caaatttttt agagtctgaa tacaatataa
    39061 ctttaactag tgcagaatta tactacttag tatttcagtt aacaaacaaa accacagtct
    39121 taaattatca tgaaatggat actaagtcat tgccaaatta tatagatgaa cattttgtta
    39181 aattaactaa aaaaataatt aaaaatgtat atgacttata ctttatagat ttatctgatg
    39241 atgaatttgt tgtaaaattt actcttcatg taaaaaattt aatcagtagg gctaaaaata
    39301 atcaagtttt gagaaatcaa atacctcaga agttaaaaga ttcctaccct ctgatatatg
    39361 atatatctgt ttatatttgt aatcagattc aaattttaga aaacatagaa atagatgaag
    39421 atgaaatatc gtatatatct cttcatgtag gttcattttt tgatagacaa aaattactag
    39481 aagataaaat tctctgtgca ttaattactc caaattacta tgatttacaa ttcaaaatag
    39541 taagagacct tgagaagaga tttaatgaat ccatagaaat tattcagatt ttttcagata
    39601 ctcataatct tgattttgac aataaggtag acatggttat tactacttta ccaattagcg
    39661 atagatgccc tatacctttt gtttatgtaa atccttacct aaatagaaag gattatgata
    39721 atattcaaag taaatttatt cagattaaag atagaaaaaa tatacttact gtacaaaatc
    39781 atttagaaat gtactttagt gaatctttgt ttatgaaaaa tatatattta gatagtgcta
    39841 aagattatat aagatttatg ggaaatattc tgtacgaaaa taaatatgtc aaacccaatt
    39901 atatagatga tgttcttata agagaaaaaa tgtcttcaac tgcatttaat aacaatgtag
    39961 caattcctca tagcatgaaa atggatgctt taaaaaccgg agtatgttta attgttaacg
    40021 ataaaccagt taaatggggt gaggaaaaag ttcaaattat agctatgata cctataaatg
    40081 aaaaagaaaa agaaaagttc aattacatat ttgaaagctt tattgaaata ttatctgagt
    40141 ggaataatgt taaagaactt actaaggcag ataactatag tagttttatg aatagaatag
    40201 cttatcttat tcaaaatatc taaatcaatt aatttatttc caatatatgt ttcttaagtt
    40261 attaacataa aatagataag ctgtcacact aaaaagtcta aattaatatg tgacagcttt
    40321 ttacctaata taccttgttt taatactaca tattttttga ctgttgtata ctagttataa
    40381 gattgaatat ttgtgttgtt gtagctgtca tattctcact agcagttgct ttatccattg
    40441 cttcttctat tgtcatagct ctatttacta tagaaaaata agcatctata ccctcttcat
    40501 tacatttaac tgcatcttct gttgtggctc cagccaaacc tattactttt accccatatt
    40561 tttttgccag ttttgcaact cctattggag ccttgcccat agcagtttga ttgtccaatc
    40621 taccttcacc agttatgaca aaatctgcat cttttaactc ttcctctaat ttaatttctt
    40681 ctaatattat ttttattcca gattctaatt ttgaatttaa aaatgctaaa aaagcaaaac
    40741 ctaatcctcc tgctgctcct gctccttcta cattagctac atctttactt aagtaatttt
    40801 taactacttt ggaaaaattt ctaagcccat tatctaactc ctcaattatt tctgatgttg
    40861 cacctttttg agacccgtat atgtatgcag ctccattttt cccaaacagc ggattattta
    40921 catcacaggc tattttaaac ttacattcat ctaattcctt taatctattt tctattttta
    40981 tatgtcttat ttcatttaaa acttttccac ctaatcctac taacttgtta ttttcatcat
    41041 aaaactcaaa ccctaaggct tgaagcatac ctatcccagc atcattagta gcacttccac
    41101 ctatcccaac tataaaattt ctatagcctt tatttattgc ttcttttatt atttccccaa
    41161 caccataagt tgtagtgtat aaaggatttc taagttcagt cggaaccaat gttagtcctg
    41221 atgcttgagc tatttctatt attgctgtac ttgtattttt taataatcca tatgttgcat
    41281 ccactttttt agctattggt ccagtaactt ctatagtatc ttttttacca ttcatccctt
    41341 gaactaaggc atctactgtc ccttcaccac catcagcaag tggcaatatc tttacttgcg
    41401 catcttcttt aaccttcaat atcccctttt ttattgcatt tcctgcctct attgaagata
    41461 agcttccttt caaagaatct atagaaatta atattttcat atttatctac tcctttttat
    41521 tactccttat tttaaacata taattttata agcttaattt atcttttatt ttatactcta
    41581 catctctctt tgtatacaac ttataccatt aatattcttt tatcttataa aaagggagtg
    41641 tctcaaaata aatttcttag ttcatgagac actctttttg tataaaatca aatatatgtt
    41701 tattatttca acaatgataa ggaggattat ctctatttta agataattcc tttttagcac
    41761 tatttaacca gtatagtttt aacttggttc attaagcact ctacatttac agagttatta
    41821 tctattgata tagattctaa ttctttttca tttaggttaa tccatttagc tgttttaata
    41881 tttttgttaa atactatgtt agctgatttt gtttcttctt tagaattgta aaatctaact
    41941 actaatgcct cttgtttttc agcctttttt acaacactta acacaaggtc cttattagtt
    42001 tccttaagta aactatatga ataatctact tctatttctg attgattcaa tttcatagca
    42061 ttatatggca ttttattata agtttgtatt tttgttaaat actctttagc catatttgca
    42121 acatttgctt ctagtgtaga tttttcatga gtaactattg ctaagtctat ttttatatct
    42181 cctatcattt gagaatctgg agtaggcaac tttattcctg atggacgacc tgggcgtctt
    42241 gccatttctt ctttacctag gaatcctaca cttctaaata atgttatagc tattgtgtca
    42301 aatttttccc ctactatttc aaactctctt gtactgtttg taagaacagc tactccatgc
    42361 tctttgtcag acaatccaac gaatgttagc attggatata tagaatctgg tctttcactc
    42421 cattcttcct gttgccaaac ttccatagca tcatcataca cacttctctt tatatgtcca
    42481 aactgattat cagacacaga aaactttgaa gctatatttg ttggtatata agttctaacc
    42541 ctacaatctc ttgcttggtt atttatgttg aatactacat ctattatagc tttatcattt
    42601 ggaacattta taactatatc aaagtcaata aatgaatctg ctctattatt ttttctagct
    42661 tgtatatctt ttggtacttt taatctataa tttatcttta tctcattatt aaatctattt
    42721 ttctttatag tggaatttgc tactatatta tcgttaaata ttaatttctc atttggaagt
    42781 ggtgaaaaat catactcatc tccttcatct cctccatttt ccatcaataa tacattttca
    42841 aaagttttat ttaatttttt atcaaatatc tttaatgtcc cgttttcatt aacttgaata
    42901 gtataaaagt cattatctac catgtcacat acttcataag ctttttctaa catatgttca
    42961 acttctttta tcatatacgc cttatacccc attgcaggta ttttatcttt aaagtttatt
    43021 gtatatacca taaatgaatc atagtttcca taatgaacaa tttgacggtc tattaatcct
    43081 gcatctatta cttctttatg taccacttca aaatccaact tattattatc tttatcaaat
    43141 atttcaaatg ctttcatttt agttataact tgagcgctta ctatttcatt cctatcgtaa
    43201 ggcattaagt taaatgctac taacttatct aaagccattt cacaactcat tgcatcaact
    43261 attcttcttt tgtaaaatgt tattaattgg tctacttttt cctcagctaa gaaaaatcta
    43321 ttcattattt catggtgaac tttatctgaa caacaacatc caatgctgtc atgagcatga
    43381 tttttcatta tttctttcca aattaactct attaatccat gatgatattc aaatcctaga
    43441 gaatatgcaa tagaagctag tggctccaat atgttggtta tctttgattc tattctagca
    43501 tttgctgatt ttatatccat tcttgttgag aatatacttc tatgaaccct catatatttc
    43561 ccatctaaaa attccccttt tattgtatct atatcctcat ttttttctag ctctttaaat
    43621 atgttttcat atctacttaa gaaaaatttt ctctctggat aacattcttt taatttatat
    43681 ataacttcaa atatattctt ttgaattggc atttggtcat gtccatttgg aagtattata
    43741 tggtcagtag ttgcaccctt atcaagaacc ggtaaatatt tatccattct tgttcttagc
    43801 tcatcttcat tcattggtag atattttcct attgcataac ctaatggaag tatttgaacc
    43861 aaaacagaag acccatcatc actcttccaa ttaaactctg ttttattagt tccttttctt
    43921 tcagaacatc ctctccaaaa cattgagtat tttatatcaa acccatttag tatttgtggc
    43981 atttgagcac tttgaccaaa tgaatctggt aaatatccta ttttcatata ttctccaaat
    44041 tcatcacaat cttttattcc atatagtaaa tttctaagta tggattctcc accaactacc
    44101 atttcatcag tttgagtata ccaaggacct attattagcc ttccttcttg aactaatttt
    44161 tttattctct ccttacattc aggcttaact gctaaataat cttctaatat agcagtttga
    44221 ccatccatca cataatatgg atagttatga ttattttcta acatatccat tatttcttcc
    44281 atattattta caagtaatat tctagattcc tcagttgaga agtaccattc tctatcccaa
    44341 tgcatatgag gaactatgtg tacatttttt ttcattgctt atcctccaaa acttatctga
    44401 taatattttc tgtctaatta aaaatccaat aaaaatacta ctgagtttac aaaatttttt
    44461 aatatttatt ttatcactat aattaaacct ttgatttaaa tatctaataa cgtatctttt
    44521 aatgtatctt tctttgattt ttttgtttcc tagttattat taataatact gctgatatta
    44581 tagctccaag tactgccgca aagaaccata ttgatgctat aataaatcct gacatacttc
    44641 cctctaaaag cgccaatgag aatatccccg ctccaggcac ttgaagacct atattgaaga
    44701 atgctactat agacccagtt atggctgaac cagctaccaa tgatggtata acacggattg
    44761 ggtcctctat cataaatggt attgcacctt cagttattcc agccaatcct aatatccaag
    44821 tttgctttcc tatttccttt tctgattctg aaaataaatc tctgcctaaa acagtagcta
    44881 ttgtaactcc aaaagctgaa accatcttaa ctgatgcaaa tattgcataa ggtataaaat
    44941 ttccacttgc tattgctcct attgcaaatg tataggctgc tttatttatt ggtccaccta
    45001 agtcaaatga aaccatagct cctattattg cacctagtag tattgcattt actccagtca
    45061 tcccatttaa ccaatttata agaccattgt taagtgctgc tacaggcttt cctactacaa
    45121 ataacatcaa taaacctact accaaagaac caactactgg atatacccaa aaacttacga
    45181 atccagctaa tgtgcctttg gctggtatat tcttctttaa aaattttact atataaccag
    45241 caagtaaacc tcctaacata cctccaagaa atccactacc tattaaatca gctgctagac
    45301 ctgctgcaaa tcctggtcca agacctggtt tttcagctag tgagtaagac atatatgctg
    45361 ataatactgg aaccatcaat gtacctaaca tacctccaga aagctttctt aattgccata
    45421 accaagaacc ttcttgattg tatagttctt gtagaccaaa tgcttgagat gctaatactg
    45481 caaatgcaag tatcatacct cctgccacaa taagtggtat tatatgagat actcctgtaa
    45541 gtattgctga ttttacatct tttttccatg atgatttttc acaatatgat atatcagatg
    45601 atttttctat ataatcacct ttaccttgtt tttgtgctac ttctaaagct tcgtatatta
    45661 tttcttttgc tctttttagt ggagctgcta ctgacgtttt tatgtttggc aaatgttcaa
    45721 atctttctgt atttttaggt gctacatctg ttgcatatat tattgcatct gcccttttta
    45781 ttatatctgg tgtatgaggg tccaccatac cattagctcc ttgcttttct acatacacat
    45841 ccacaccgat ttctttacca gctttaatta atgcttctgc tgacatatat gtatgtgcta
    45901 tacctgcagg gcatgctgtt attgctaata taattttttt tgattcattt tgaatcctaa
    45961 tctcttcttt tatttgttct ttcttttctt ttatatctaa gttattaaat aactctttct
    46021 tagtttttga atttaacaac atattcatat aatcttcatt tgacagtcta gtaactaact
    46081 cagaaagtat ttgtatgtgt gtatttccac cttcattttc tggtactgct attaaaaata
    46141 ttatctctac tttattattt gggtctacgc tttcccaatt ttctattggt gtctctaagg
    46201 tcatagctgc aaatgcagct tctttaactg acttagattt tccatgagga attgcaagcc
    46261 ctctttcaaa gcctgttgga gataaagttt ctctgtacat tacagcttct aaatattcct
    46321 cataagatgt taacttgcct tcatcatata gctttcttgc taagaacttt attgcgtctt
    46381 tctttgtttt tattttttgt tttaaaaaaa caaggttttc atttgtgatt ttcttaaatt
    46441 ccaaaattac gccctcctta aatcatttaa tgctatgaat atagcataaa ataaattatg
    46501 aaaatgtttt tttgaaatta tacacacaat ttcttcttaa aaaataaaga tttgtgtatt
    46561 tatacacaaa tctctatctt aaccagtatt gctctattat tgctctcata atcatcataa
    46621 ttggaacctt atctgatata ttgtacccat ttacttgttt aattgttgaa tagcaatata
    46681 aacttatatc tgcaatttgt tgcaattgat tttcacatat atgtgttaga gctactacct
    46741 tacaaccctt attaactgct gtctttgcta cttctataac ttctttcgtt tctccactta
    46801 aactaagtgc aaaaaacata tcttgttcac ctaattttcc tatatcatga agtacttcat
    46861 gtctttgact atagtaagtt atattatcat gcccacctct aatttctttt actaatatct
    46921 cacataaagg aatgttttga cctattccat aaactataat actcctagat ttttgaatta
    46981 tatctgctac tttatttatt ttttcataat ctattagctc taatgtcttt tttatatctg
    47041 attcaaaacc attttttggc tctttatcct cattttttaa ctcttctttt aaattatttt
    47101 ttagttgaga gaaaccatca tactccattt ttttacatag cctaactatg gtatttggga
    47161 cagtaaaaaa tttatctgct aaagattgta ttgataattt tactatttct tctttgtttt
    47221 ttctcatata ttcaattatc atgtcttctg tatctgtaaa tttatactca tatttttttg
    47281 ctctttcata aaattccata gtttctcctc catctatttt attattcata agtaaaattc
    47341 aaaaatatta gctaaaattt tcgttaatat aattataatt taatattttt aatttattaa
    47401 tgcatactac tctttttatt atacataaaa aatgtgtact tcctatattg atagagatga
    47461 ttcaagtttt tattttgata catctctatc aatatttttt tagaaaatac acattttttt
    47521 caaatactta tttttaatta aaactttagg taatctattc tttatatata attattagac
    47581 ttgaaaatat ctttaaaatc aaccaattca atattatttc tttttaacca cattttaact
    47641 tccttatcac atagcattgc atgttcatat actctctctt gaataagaga agatgatttt
    47701 ataagactat aatctataaa tcctggatga gtaaccatca atgttatatc tttatctaaa
    47761 tttatatatt tttcttcaaa taatttaaca aaagatttat ttaacttgta aaaatcattc
    47821 tgaggatatt tacttggcat gctaatacat gaatccaaat aatagggaca acttggtata
    47881 ccgtattctt ttgcagcatc acacattgct gatattgata catcttcttc tataccatgt
    47941 atatcaatat actcaggcaa tttactcata tacaacttgt aagtttcaat ttgagcacaa
    48001 acttcttcat atacttcttc ataattaaaa acctctttac ctgtcagtag ttgcgttctt
    48061 cttattttgc tagaaacaaa ttttccacct tcatctaaca aattctttat cttaatatgt
    48121 tctttgcaac aaggttctcc tattactaaa ttaacatgta aaccaaaaca tacatcatca
    48181 ttttttacca tttctatagc ttgtcttgaa aaaggcatat tcaccatgat tccagcactt
    48241 gtaacaatac cgttcttata agaagatatt atccctagtg taacaccttc tgaatatcct
    48301 atatcatctg ccctaactac tagtttcttc attttatgcg tctgcctgct ttctcaactc
    48361 atcaagttgc atttccatct catcctttac tttaacaaca tccgttccta tgatgatttg
    48421 aactgatgta ttactcaatt taattacccc tttggctcct gtttttttaa tattatcatc
    48481 attcaaaata gtagcatcct tcacttctaa acgtaatctc gtcatacaat tattaagagt
    48541 cactatattt tcataaccac cacaattttt aattatctgt ttagccatat atgaaaaatt
    48601 accatgagaa agttttaaat tcttttcttt ttcactaact ttatcaccta tctctatctc
    48661 aacttcacgt cctggtgttt gcacattatc ttttattatt atatatttaa atgttacata
    48721 atataataca aagaatacaa ctcctacagg tataactaac cacgctttat ctccataact
    48781 aaaacttaag acatagtcaa ttatacttgc tccattaaat gaacccaagc gaacacccag
    48841 taaatatagt acaactccac ctagaccaga ataaaaagaa tgaattatat ataactttgg
    48901 agatgcaaat aaaaacgaaa attctattgg ttcagttact gttgccataa aagaagtcaa
    48961 tgctccagcg gtcattgcac cttttacttc ttgcttcttt ttatcttgtg ctgttttata
    49021 tatagcataa gaaatagcag gtattgaaaa catcataatt atgtaaaatc ctgtccagaa
    49081 gaatcctgca tttgggtctc ctgccataaa tctaggaatt tctcctctta taacttctcc
    49141 tgttgatgtt gtatattcac ccatttcaaa taatatgtaa gcatttaaaa cttgatgtaa
    49201 cccagttggt attagtgcac ggttacagaa taaaaacaag aatattccta ttgcaccagc
    49261 tcctcccaac caaaaaccaa attgattcat tgcagcttgt ggatatatcc ataataaact
    49321 aaatatatat gataaaatta aagcaaccac tggtgatagt gtaattacac atttttctcc
    49381 tgcaaagaag cttaaaaatg ctggaacttt aactttatat gttttattgt aagtccatgc
    49441 tatacaagct ccaacaatta tcccaccaaa tacacctgca tttaatgtat cattcaataa
    49501 ctctaaattt gacttaaata tcatatatgc aactacggct gcaaccatta cacttgtctt
    49561 gtctttagac tttgagtagg cactagctgc tcctaataaa aataagtagt ccacatttga
    49621 aaatactata ttagatatat tagatatagc tggcacattg agcatatttg gaccaaataa
    49681 taatcctaat atacctgctg ctggcattac agctattggc actagcatag tctttcctaa
    49741 aagtgacagt tgttgcatca ttttgtttaa gaacctcttc atatccaatc ccctttctat
    49801 ttcggtttaa ttttttgtga aaacgattta ttcacatttt atattttaaa tattatattt
    49861 gtttaaacaa attgtcaata ttttttattc attttatttt tatcatttag tttaacatat
    49921 aaatcctttt aagtgtattg ctatatctag tctatttttt taattcattt tttttatttt
    49981 aaaaatatgt ttaaccatgt atttgaaaca acccacaaaa taattctatt ttgtcctttt
    50041 tatggttgat atgattctat tttcactata catgtctaaa cacatttgat ataatttgtt
    50101 catatcagtt caataatatt actaaagacc tttaaggagg gataggggta tatggctaaa
    50161 aataaatttt cagagatata tgaagtattg aaagaggaaa tacttgatgg taaatataca
    50221 agtaatatga tgctgcctac tgaacttcaa cttattgaaa ggttttcatg tagcagaaac
    50281 actgtacgta gagcaatttc tcaattaaac acagaaggat atgttcaaag tataaaaggc
    50341 aagggtgttg tagtgttaga aaatagttgt tctaatgatt tttttctaaa tatgcacaat
    50401 ttcaaaggtg tagaatcgat tgtagaagat aaaaaggtta atactgctac tagtgttctc
    50461 cacttcagca aaatcttaat tgataataag ttatctaaaa agacaggttt taaagttggt
    50521 agtgaagtat attaccttca cagactaaga tatattgata acatacctaa aattctcgac
    50581 attaactatt ttctatgtag tatagttaaa gaccttgatg tttctatagc acaaggctct
    50641 atttataaat atatagaaga gtgtctaggt acaaaaattg tttcatccag aaagatattt
    50701 aaaattgaaa aagctacaga gcttgagtta aaaacgctac ctctaaatga ttataattgt
    50761 gttggtgtta ttaaaaatag tgtatatact gatgatggaa agctttttga atatactgaa
    50821 tcaaagcata cacctgaaac atttgtattc atggatgtta ctcaaagata ttaaaaaaat
    50881 tatgtttaat taaacataat ttttttacgt ttagacactt tatcccatac taacctcact
    50941 attctatata caattatgtg tttatacaaa taattattta ttgtatattt tagctttaat
    51001 attagtttaa tgcttgacaa tttgtttaaa catattataa ttaacttata aattacagga
    51061 ggtatcaatt atgaaaaatt ggtggaaaaa agcaactgtc tatcaaatat atccaaaaag
    51121 tttcaaagat agcaacaatg atggtatagg tgatataaat ggtattatag aaaaattaga
    51181 ttatctgtat tatttaggtg ttgatttatt atggttgact cctatgtacg tttctcctca
    51241 aagagataat ggatatgata tagaagatta ttataatata gacccaaaat atgggacaat
    51301 gagtgacttt gaaaaactct taaaagaagc tcataaaaga gacataaaaa taatgatgga
    51361 tatggtccta aaccatacat ctactgaaca taaatggttt aaagaatcta aaaaaagcaa
    51421 agacaatcca tatcgtgatt attatttctg gaaagatgct aaacctgatg gttctgttcc
    51481 taataactgg atatccagat ttagtggaac tgcttggaaa tatgatgaaa ccactaacca
    51541 atattattta catttatttg aagaaactca agctgattta aattgggaaa atgaaaaggt
    51601 tcgtgaagaa tgttacaaaa tactagaatt ttgggctgat aaaggtattg atggttttcg
    51661 tttagatgta gtcaacctac tctccaaaac acctggatta cctgatgacc ctataacagg
    51721 accaaaagga gatggaagaa ctcactacgc tgatggtcct cgtatacacg aatatttaca
    51781 taatatgaat caaaaagttt tcaaacctaa aaatatagtt actgtaggtg aaatgtcatc
    51841 tactacacct gaagagtgta tcaactatac tagagaaaat cgagaagaac tatctatggt
    51901 ttttagcttc catcatatga aaacagatta taaaggaggc gcaaaatgga ctaatgaaat
    51961 gttctctctg gataaattaa aaaaagcaca atctgacttt caatataaaa tgtatgaagg
    52021 aaaaggatgg aatgctctat tttactctaa tcacgaccaa cctagagctt tatctagatt
    52081 tggagatgat agattttttc gtcaagaaag tgctaagatg ttagccataa cactatttgg
    52141 tctacaaggt actacataca tatatcaagg tgaagaaata ggtatgacaa atgcctactt
    52201 tactaaaata gatgaatatg atgatgctga aagtaagaat gcatactatc atatgattaa
    52261 atctggtatt gatgaaaagg aggcattgct tatacttcaa caaaaatcca gagataatgc
    52321 ccgtactcct atgcaatggg ataatactat ttataagggg ttttctaatc ataaaccgtg
    52381 gttaaaagtt aataatgaca atattagtgt agaaaatgag cttaatgatt ctcgttcagt
    52441 attttatact tatcaaagat taatcaaata tcgtaaacaa tatgatattt ttacagaagg
    52501 tacttataga ttgttagatg aaaatcataa aaatctattt gtttatgaaa gagagtataa
    52561 aaaccaaaat cttcttgtta taagtaattt cactcatgat aatgtagtat ataaattacc
    52621 tgaaacttat ttgaataaat taaactacac aatacttgaa accaattaca ctagagatat
    52681 aattgaaaat aaaatggaaa taaaacctta cgaaagtata atgatatatt ataaataaag
    52741 ttatttatgt aaaaataggt ataacaccct ggtgttatac caattttact aaattcaaag
    52801 taatgtttat agaatatcta tagattacaa taattatttg acttctacat cattatattt
    52861 ctttgaatat actttagtca tatagaaata tataggaact acaattatca tcccacctaa
    52921 tccccaaact atcttcatag gttcatcaat acctgctttt atcagtaata atatacttat
    52981 aataactgca aatattggta taattgctcc tccaggtatt ctaaaattta catctttacc
    53041 agcatacttc tttctcaata ttagtacagc taaacatgta ggaatatatt gaataaatct
    53101 agatacaaca cttatttgag ataatgttgt gaatgaaccc gaccatgcta ttagtaaagt
    53161 tcctatgaca gatactataa ttgctatata aggagctcca tttttattag tttgtcttat
    53221 agacttaggc attaatcctt gttcaaccaa agcagcagca gaccttggtg taaatatgga
    53281 tgatgcaata tttatacctc caacagatac tatagttcct attgtaatta tatacccacc
    53341 tataggacct aacatcttaa tggcagcatc tgcaacagga gtagctgacc ctgctaagcc
    53401 attacccaac acccctatac ttattcccag tataagcata tatattactg atactacaaa
    53461 cattaccatt accaatgctt taggtacatt tttcttaggg ttctccatat cttttgctgc
    53521 aacagctaaa gattcaaatc ctgtaaaagc ataaaataaa gttatagata ctgctacaaa
    53581 agctgatgac gcactttgac ctttttgtat tattacaaat ggggtaaaat tagaaccctt
    53641 tataaagaat aatcctacag ctataaataa aactattggt aataattttc ctatagtcat
    53701 gatattattt aagtgcttag attgtttcat tcccataaaa tttataatcc caagccctac
    53761 aactaatata ccaattatta tatttttaat aagtggttct gctgcttgtg gccatacaga
    53821 tgatagtgtt acagcaaaga aatttgccat agtagcccaa gcaatcatac taactatcca
    53881 cttcataaat ccaacttcaa atccaacaaa atctccaaat gcctcttttg cataaagata
    53941 gggccctcca tcagtatcaa accaactacc tgcttcagca aaacataaag caatagaaac
    54001 agctaaaagc atacaaaaaa ctaatactaa tatacttgct ggacctatat ctgtataagc
    54061 atcaccaggt aacccgaata tacctgaccc tattattgca ttgattccta atagtacaat
    54121 actccaaaaa cctaacttaa tgcctttttc cattgttatt ccccccaaag ccaacttaat
    54181 atatttgtat tttttattta gatgcttctt taactattgc cataaatatt tttttcatat
    54241 tatcataatc tctagtcatc atttctggat gccattgtat ccctattaca aactcacttc
    54301 cttccttttc tatagcttca attaaaccgt ctttagatgt agctgaaaca atatatcccg
    54361 gtgctacttt gttgacaact aagtgatgaa aactattaac taaaacttct ttttctccta
    54421 gtatttcata taattttgtc ccctccttta tctgtactgt atgtgtaggt acattagata
    54481 gatgttgctg attgtgttta atataagcac cttcaattaa agataaatct tgatacaaac
    54541 tacctccttc agttacattt ataatttgtt ctcctctaca tatacctaaa actggttttt
    54601 tcatatctaa agcatgtttt aataatttca tatcaaaact atctctcttt ggtgatattg
    54661 cccccaactt attatgaggt tcttctttcc atatgagtgg atttacatct tgtcccccag
    54721 atagtataag cgcatctata ttagatacct gctcctttat aatctcatca tcatatacaa
    54781 tcggtacaat atatggtata gctttacaca taactactga ttgtatataa tcattattta
    54841 cataagccct ttcatagcca ggaaacattc ctccttcatc aattagtaaa ttacctgata
    54901 ttcctattat tggatatttc tttttagcca atttcttcac cccttaactt atttgtgaac
    54961 aataaaaaat gctacttctc ttaaagagca agtagcatac caagatttta tttatttgaa
    55021 cattataatt tattttagaa atactttttt tgaatacgag taatataaat aactttattt
    55081 acttatattt tattttaatc ctgtttagtt tgactttttt aaattgtttt aagtacaact
    55141 aataggtaaa ataggcattt agattttcct ttttatcaac ctattaaata ctgtttaata
    55201 tattttttcc ccttctattt aattcacttc cctttctacc agattcacat attatcaaat
    55261 ccagctcttt taacatatta agtattcctc ttacctcacc ttctgttata ttgtagccta
    55321 attcatttat tgaattaaca ataccatttc tacctatatt tttattaaga ttattggcat
    55381 tttttaaaca ctccattact aactttactt tctctataga tgttctatcc tttaatatgc
    55441 ttatttcttt actaaaatct tcagttatat ttaataagtt atgaggtaaa tcatttatta
    55501 aaataacatc ctcagaactc ataatgttaa tatacatagc agtatttttt aattctctta
    55561 tattacctgg ccattcatat gcattaataa tgtcttgaac atcttgacta attgctctct
    55621 tccttttcat aaaatgcttt aacataactt ctatatcttc ttttcgctct cttaaaggtg
    55681 gtatatttat gggcaataca tttatcctat agtataaatc tgctctaaat ctatctcctt
    55741 ttatcatttc taataaattt ttatttgtag ccgcaattac tctaacatct atatctatta
    55801 cattttctcc tccaaccctc attacttgat tctcttgtaa tactctaagt aatttgcttt
    55861 gtaagtatat aggcatgtct cctatttcat ccaaaaatat agttccattg ttagcctgtt
    55921 caaataatcc ttttttacct ccttttaaag ctcctgtaaa agcaccttct tcatatccaa
    55981 aaagttcact ttcaagtaaa ttttctggca tagctgcaca gtttattgct ataaatggct
    56041 gactatgtct tggtgatgca ttatgaatag actgagccat gagttctttt cctgttccac
    56101 tttctcccgt tataagaatt gtataatcag attcagctat tttcatacct aatttcttag
    56161 ttctttccat cttcgttgaa actgttttta tatcatcaaa agtatatcta gcaacttgtc
    56221 ccttttctct aagcttcttt gataggtttt gctccaattt tcttatgtaa gttatttctt
    56281 gaatacaaaa ataatatcca gtaacccttc caaaactctc tatattatac ttatttacgt
    56341 ttaagtactt attattaaat tttataactt catcatgtgc cttactcaaa ctaaaaatct
    56401 ttttaatatt ctcattctct aattcatcta tatttttccc tataatatta ctttgaatat
    56461 ctagtatatc ccttaaacta ttattacaaa taattatgtt tcccttatct gataccattg
    56521 ccatacctaa gtttgataaa tttattatgg aatttagttc atctgctttt atagtaagtt
    56581 ctttgtattt agtatttatt cctgaatata aactaattat ttcatctgta tacttaatta
    56641 gcctctcagt aatttcttta tcatccagtt tgagttttgc tattatttga ataaacgttg
    56701 aactatcaat atacctatgg cctaaatcaa taacttcttc tatatatttt ggaactaaac
    56761 ttgactctcc tggcgttata gctatcttaa tatttctata ttcttcattg ggattgtatg
    56821 gtataaaatt caaatgattt attcctatat tgtataaatt agatattgtt tccaatacag
    56881 tatgcttatt atcgtttact actaatacat ctattccttc tggcaatgaa aataacttat
    56941 atatatcctt ttgctttatg ctcctattta tagttattat ctttgagaca tcttccacat
    57001 atttttttat ttttaatact ctatcatcta tcattaccaa tattatgtca tcttttatta
    57061 attccttctc tgttatttta tttaaataat aattttttat cattacttta tctttaaaga
    57121 tcatttctag atttttattt aagaaacatt ctaatttaga caacccatca gttactactg
    57181 ctattgtttt catttgatta ctccttttaa aatatactct actcttttat aatatacatt
    57241 tgattttcac tttaataaca caaaaaattg tacatttagt atactaacat attcctttat
    57301 tagttttatg tccataaata tcatagttgc aatatctatc atatttctta aacttctata
    57361 aagcaaaaat tgtgccaaat taataatttt cttaatttta ttctaaagtt cctcaatagt
    57421 atttacagac ttagcactta tagcttataa gtctttatat tattaatcta tttttatagg
    57481 ttaattgtac aaatcatata tcacttttac ctattaaatg cattataaaa aattgtattt
    57541 ataaacacta tttactactc ttctaagtac aaacagtatc tacatactat aacctttcac
    57601 cattagattc tattacttgt ttataccagt caaaactctt tttcttaatc ctagacaagt
    57661 ctccacttcc atcatcatac ttatccacgt atataaaccc atatctcttg gccatctcac
    57721 cagtagatgc acttactaaa tctatacatc cccatggagt atatccaaat aaatcaacgc
    57781 catcttctac agcttccttc atttgctcta tatgtgcttt taaatactct atacgatagt
    57841 catcatttat cactccatta gattcttttt tatcataagc tcctaaacca ttttcaacta
    57901 ccatcatagg tattctatat ctatcataaa tttcatttag tgcatatcta agcccttcag
    57961 ggtctatttg ccatccccat tcactagact taagatatgg atttttcact ccacctaata
    58021 tgttgccact tgtattatct tctttagaat cactacttac acatgtagac atataataac
    58081 taaatgtata aaaatctaca caaccttctt ttaaaatttc taaatctcct ttttccattt
    58141 ttatttcaat attattttct ccaaaatatc tattcatata agttggatat tcgccacgca
    58201 cttgtacatc tccacagaaa taattcatta ctctactatc tctttgagtt ttaactgcat
    58261 catctggatt acaagtataa ggatacattg ttgcaaatat ttgcatacat ccaacttgat
    58321 aatttgaatc tatttcatga gctaacttaa cagccttagc acttgctaca aattgatgat
    58381 gtaacccttg aaaacgaagt tgaggtatat ctacttggtt tataaaatct gtagtccctt
    58441 catttaatat tccttgtgat aagtagcctc ccataggcat tgtagctgaa tttatttcat
    58501 taaatgtcag ccaatatttt acttttcctt tatatctttt aaatattgtt tcacagtaat
    58561 tcatatacaa gtctattaca tctcttgaaa cccatccatt gtatttctct gttattgcaa
    58621 atggtatttc atagtgagat attgttatta atggttctat attatatttt aaacattcat
    58681 ctatcacatt ttcataaaat ttaagtcctg cttcatttgg ttctttctcc attccagttg
    58741 gaaatattct agtccatgct attgaaaatc taaatacctt aaatcccatt tctgcaaata
    58801 aagctatatc ttctttgtat ctgtgataaa aatctattgc ttcatgactt ggataaaatg
    58861 ttcctttttc tataactctc gttattcttt tacttacttt ttgagaacct ccagtacaca
    58921 tatctgaaca agaaggacct ttcccatcta aattccatgc tccttcacat tgatttgctg
    58981 ctgttgctcc accccataaa aaatcttttc taagtgccat aattctacct ccaataattt
    59041 atttatagta actttatttt aaaataaaaa tacatatata taattcttaa ttaatagaac
    59101 tctcttttac gctaaaacag ttatcaattt ctgactatta tttacatgct tttgtgtatt
    59161 ttctacaata tccacataat cagaataatt agtaacaact actggtgttt ctaagcaata
    59221 tccttctttt gaaatacttt ctatgtcaaa agttattaat gtctgacctt ttttaatctt
    59281 atccccttga ttaacaaaag atttgaaata tttaccttcc aactgaatag tatttaaccc
    59341 tatatgtatc aatagttcac aaccattatc agatataatt cctattgcat gttttgttgg
    59401 aaataaagtc attacagtcc catcaaatgg tgccactact tttccttctt taggtgttat
    59461 tgctacacct tttcccaata tacctgttga aaacgctgca tcttgtatct gctccaaagc
    59521 ctttacttca ccttttattg ggctatatac tacttctctt ttgttttttt ctataacgcc
    59581 ttgcccatta tcatctttag aaatttctac tatagcatca tctttccaaa aaaataatgt
    59641 taaaacaaat cctactacaa tagctactat tattgctatt atagttgcat aaacaccttt
    59701 catatctcca gttgttggat ttatataatt aggtatacca aatattccaa gtccacccat
    59761 tacataactt tttacattca ttatccccat tacagctcct gccacagcac cacctacaca
    59821 actatatatg aatggtgttt ttcttggtaa agttattcca tatattgcag gctctgttac
    59881 accacatatc cctgaaataa ctgcaggtat acacagctct tttatcttct tatcttttaa
    59941 tttaaagtac attgctgcta ctactgctgt ttgtgcaaaa gatggtacaa atactcccac
    60001 taatattgtg tcaaacccca tagtcataag gtttgacata gctattggta ctaatcccca
    60061 atgtagacca aatattacaa gcacttgcca caataaacca gttaatgcac cacataaaat
    60121 tggtgaaaag ttaaataaag ctaaaaatcc atttccaact atattagaag cataggtagc
    60181 tataggccct ataaccataa atcccaatgg taaagaaact aataaaactg ccattggtac
    60241 aaagaaattc tttactacat ctggtattat tttagcaaac actttctcca acttagctgc
    60301 taataatact attaaaatta ctggtactac tgttgaagtg tagttcattg ctattactgg
    60361 taatcctaag aaagttatat atactggtga ttcaaatatt gttccagtaa atagattgta
    60421 taaaggttga cctgtagatg ctagagtatc taattgaata cctgaatagc ataaaactgc
    60481 acctataagc attccaataa atggttttaa tttgaatttc ttagcagctg tatatccaag
    60541 aattattggc atatactgga acattgcatc tccaattgca tttaacataa tatatgcacc
    60601 atcagtttct ccatacaaac ccaatgctgt aaatactgca ttaaatcctt ttatcatacc
    60661 agcagcacac agaactccta atattggttg aaaaactcct gatattatgt ctataaactt
    60721 attaagtaat ccttttggcg catctgagtc tgaattatct attgtatctc ctcctaatcc
    60781 agccaaatcg cacacaactt cataaacatc tggaacatga ttaccaataa ctacttggta
    60841 ttgacctgca cttttcatta cagtaactat accatccatt ttttttagca catcatcatt
    60901 tgctattgac tcatctttta atttaaaacg tagcctcgtt atacagtgag ataaactgct
    60961 aatattatcc tttcctccta cattcgcaat gatttctttt gatagttgtt catactttct
    61021 cattttttct cctccatttt ctttttgaaa tatgaaggtt tggccaactt aatgtcacca
    61081 cccaatatat ataaacctaa ttattaggat ttatatccga cttaatactt ttacttacca
    61141 ctctttcaac gtgaatagtt aagtataatt tttcctcatc tgttaaatcg tagttgtatt
    61201 ttttatgtat aaattcatcc aacttttcta tgaatttata agcattttta tatttaactt
    61261 ttattacatt taataaatca tcttcattat tttcatgtaa attattacta acaattcgtt
    61321 ctgcaaaata ctttaagtga gtaataaatc tatgataata aactgaatct tcatcaaata
    61381 ctattctgta atggtattta accatatttg aaatttcttg tattatttgt gtaatctcat
    61441 atatagtttt tatactttga tccatttgtg cattaactat atgcagtgct ataaatccag
    61501 cttcatcttc tgatagtcta atttcaaatt ttttttctat ataatccaat gcctctaacc
    61561 ctattttaaa ttcactctta taaaatcttt ttatatccca aagtaataca ttttttacac
    61621 ttactccttc acgagctctt tctattgcag tatacatatg gtctgttaaa gaaatataaa
    61681 tactatcatt taatcttttc cctagttttt ctttagcata taaaattatt tcatctgata
    61741 attccatata tcttatagga atatctgcta ttagttcttt aaatttatca gatatatttg
    61801 ggtctgaaag tttgaatatc ttatcaattt tatcctttga tatatgctct cctgtacgtt
    61861 ttttataagc taaacctctc cccataacta ctatttcctt atgattttca tcagttgtaa
    61921 taattacatt attattgagt attttttcaa taatcattgt gatgccccct ttattagcat
    61981 taagttaaaa taaatctttt ttaattattt agaatattta aaatgtaatt tattacataa
    62041 aaaaaaacct atttattaca cattaaatag actcccatga gtcctgagta ataaataggt
    62101 ttagcttgta tttaaacaat cactatccgt ttgtatttta ttttaattat tatttattat
    62161 atgttagcaa atttattttt tagtgtcaac tttttctcaa tattttaatt ttaaataaat
    62221 tatataaatt gaatcttcaa agtactattt ttatcaataa acaaaataaa aaaggtatta
    62281 ctttctttaa gtaataccca tttatttcta atttaagtgg tttttcttaa tctcatcaag
    62341 tagtccatct tctaaataaa tttctaatgc acatcctacc attgccttta ctgctttgtg
    62401 aagtttatca taagcttcct cagaatttgc ataatttaga aattcttttt catgaacata
    62461 taccattgga cttatatcta aggctatttc tgtatacata gtagggcaaa cttgacttac
    62521 attacctata tctgtagaac ctactggacc atctttacct tctaatatat ctgttatacc
    62581 tgcctcaatc aaattattct ttgttatctt ttgaagtact ttgttattta ttatgttgtc
    62641 aaaagaattt tcaaagtatc tataagaaag cttagctcct gtcattaact ctgcaccttt
    62701 tgcacagttt ataacttttt tagttacttc atctaaataa cttctttcag cagctcttac
    62761 gaaaaactta caagctgctt tttctggaac tatatttgga gcctctcctc catttgaaac
    62821 tataccatgt attctaacat ctgattttac atgttgtctt agtgcattta tcccagcaaa
    62881 agtaagttgt actgcatcta gtgcattgac tcccatatga gggtgactag ctgcatgtgc
    62941 tgatacccct tcaaaactaa actctaatga atctatcgcc aaagccttac agtttatatt
    63001 attaaaagct tctatatgca tttgataact tacatcaaca tcatcaaaag ctcctgcctt
    63061 aactaaatca cattttcctc ctgttgtttc ttcagctggt gttcctatta gtacaatttt
    63121 tcctttaaaa ttttctttta acttacttaa tactatacaa gctcctagtg tagatgctgc
    63181 aatccagtta tgtccacaag catgagctgg ttctttattt tctccatatc caggaagtgc
    63241 atcatactca gctaaaaatg ctatggtagg tccatcatta tctcctaatt cagctctaaa
    63301 agcagtctcc atattacaat atggataaac tgtatcaaat ccatattcct tcattttttc
    63361 tactaagtat tttgatgata tgtattcttc ttcccctaat tcaggattgt taaatataaa
    63421 attacaaact tcttcaattt cttttccaag ttcattctct atctcataag ctctcttctt
    63481 tatactctct atcataattt acctcctact agaatcctag atataatcct attgtcaaaa
    63541 atgccattac aagaattgtt aatactacca ttaaaggaat tacgaatcta acccactttg
    63601 accaaggaat attggctact gctagtgctc ccattaaaac acctgatgta ggtgttatca
    63661 agttagttac acctatacca aattgataag ctgtaactat catttgtctt gatacatcta
    63721 ctaagtcgcc aagtggtgca agtacaggta ttgtaagtga tgcaagccct gatgctgatg
    63781 gtattaaaaa tgctattaat ccttctatta agaaagttaa atttataaat atagtttttg
    63841 gtaatccatt taataaattt gctgcagaat ttaaaattgt atctattata aatccatttt
    63901 ctgctattat tacaattcca cgtgcaaatg ctatacacaa tcctgctgtc attaaatctc
    63961 ctgctccact tataaatgaa ttaactatat catcttgttt aagacctgat gctatacctg
    64021 atattatacc tatagctgta aatatcattg caatttcagt tatataccat cccaacttta
    64081 aaactccata tatcataatc gccataccta ttgtgaaaat tgctattacc atggcttctc
    64141 tttttgtaaa ttcctttata tttgtatcac tattaaccat tgattcttga tttagtgata
    64201 tatcgtgtac taaagatttt ttagggtctt ttttaacttt attggcatac atcataacaa
    64261 atcctataga tatagccata tatattataa acataacaac tctaaactct attccagaac
    64321 ctggtgctat ttgtgataat gcttgtgcta ttcctacaga gaaaggattc gtagtagctg
    64381 ctccaaatcc agctgttgct cctataaata ctgtggccac tgctgtcaat gaatcatatc
    64441 ccatactggt cataagtgga ataaatatca tataaaaagg tagtgtctct tcactcattc
    64501 caaacgtcgt cccacctagt ccaaatagaa tcattgaaat cggtattatt aaaaattgaa
    64561 acttcttcat tttatttaca gtatgagcta taacagcttc tatagctcct gttttattaa
    64621 ctatcccaaa agctcctcca actattaaaa caaatccaac tacttcagca gcatctataa
    64681 acccgtttat aggtgctgta aatacatcag taattccttg tggatttgat ggtgcttttt
    64741 cataagttcc agctacaaca actgaccttc cgtctatatc tactctttca aaatttccac
    64801 ttggcactat ccaagtaaga attgccatta acactattag caaaaatatt attgtaagtg
    64861 tctgtggcat agtaaacttt ttctttttta aactgctcat ttttaatctc cccacttttt
    64921 aaattaaata ttttattatt gcatcccttt atcctatttt gtatagatgt aaaaaagctc
    64981 aacatggata catgttgagc taaatgtgct aaatacaaca tacctgcatc ttccctttat
    65041 cttgtttaag atagctctcc atcaaaattc gggataattt tgatgacagt actgtaccta
    65101 ttaaatacag tcccagcact agcttcggac actagcactt cggcacttac tccttttata
    65161 ttgcctcatt ggtttccaac ctcttcaata ttaatcttag taaatgcaac ctctacctca
    65221 atctgtttgt tagatgaggt aattcttatt aatttttatt aattcaaagt aattgtagca
    65281 taatatgtcg agattgtaaa tattttcagt ataataattc ttactttatg atttcattcc
    65341 atttttcaca aataattttt tctccatata atttaaatac tgtagtatat tttaaataca
    65401 cacaaacttt ccacaaattt taaattatta taataccttt ataataaaaa ataaaagcta
    65461 tgtaaactta tcaatttaca cagctttata tacattaatc tactccaagt acagctttaa
    65521 gctttgatgc tattgtaata actcgtggac caaatataac ttgaactgag tttttctttt
    65581 taacaactcc acttgcaccc aattcattta cccagaagcc atcttcatag aatccatcaa
    65641 ttgaatttag ctctacccta agtctagttg cacagtttgt aacatttttt atattattac
    65701 ttcctcctaa accttctatt atagaatgta caagctttgt atctttatca tctacttcct
    65761 cttctactgc attgttgtat gctgttttac cagcatctac agattgtctt tctctatatt
    65821 ctttcttact ataaagctta acttcttctg aacttcttcc tggtgttttt atatcaaact
    65881 tcttgattgc ccatgtaaat attatataag taactataaa aaatattggt atcaaaaata
    65941 ataatggtaa cgcatccact ttttgtggtt gtaataaatt aggaaacata tttctaaatg
    66001 attctcccat tatagaaaca ttaaacattt ctgtaaatac atacgtcaat cctgccagtg
    66061 gtacatatgc tacaaaatac aataatggtg caacaaatag gaatgtatac tctattggtt
    66121 ccgttacccc taccaacatg gctgttacta ttgctggtat caatatactt attgcttttt
    66181 tcttattagc attatcagcc aacttataca tagctaaagc tgctgctggt aatattgcaa
    66241 aatgtattaa taaacgacct gttgtgaagt tacgagttat ataagatagt gtatctgggt
    66301 ctcccatttg agctaatctt atattattaa caccctcgta aattgctcca cctacttcca
    66361 ttgttccacc tactcttgta tattctatag ggaatgcaat taagtgatgt ataccaaatg
    66421 gtaataatgc tttatccatt gctccaaaag taaatgttcc taataatcca ctagaaccta
    66481 tccaattacc aagtttagat aatgccaacc ctactggtgg ccatataaag tacattgctg
    66541 tacccaatac tattgatgct ataaacatca taatcattga aaatcttgga cctgagaaaa
    66601 aagataatgc actaggaagt tctatgtcaa caaatttgtt atgtactgca ctagctacaa
    66661 atccagctat tatagctcca aatatactac aatcatatga aaagattcct aagaaagaac
    66721 catataaaga acttcgacta tatgcttctg cctctcctaa tccagatgcc ataaacgctt
    66781 ctgctgtaac tgtatctgaa tttataccat ttgctgctaa caatgtactt ataactgtgt
    66841 gcattcctat aaataaaaca attcctccta atgcacccca tcctttttcc tttttagata
    66901 atccaaaggc tatacctgta acaaagaata ttggtaagta tctcattacc ataaatccta
    66961 aatcgtttat tactttaaag aatacattta taaatgaccc ttcttttatt agtccgctaa
    67021 gccctaatgc agaaacgttt tccatatttg caaaagctga ccctagtcct ataaatactc
    67081 ctgctacaac aagtaatata acaggtatca tcattgctcc agaaagtact tgtaatttat
    67141 ccttcatagt attatttcct ccatttttat tgaaatgcca ggctatataa tgcatatata
    67201 tatacttcta ttgctttgta taatgtatct atacttatat tttcatttgc ctgatgtgaa
    67261 tttggattat ccccctctat tgtgggtcca aatgcaactc cattttttaa cactcttgca
    67321 taagatgcag ctccttttgt aaaaagttcg gcttcttttc caaaaccttg tttatatgca
    67381 tttgataatt tatttattaa ttcactatct ggttttacat acagtaattt taaatcctta
    67441 tatatatcaa ctattaaatt ttcttttttt ccaatttcat taattctatt agttataaac
    67501 tcccaactta tacccttagg atatctaaag tctattttca tattcaattc atttttctct
    67561 aagaagatac tcattataca tattgtagaa actcccatat ctacatcttc tttatatatc
    67621 cctaattttt ttccatgatt atcatctgta aagtatgaat ttaaaatatc ccttattata
    67681 acgcctttat catttagttt tttaattttc tctaaatctt ttgctaaact aaatgcacag
    67741 ttatatgacc tgtgtggatt tctcgataaa gccctttctc ctgtatatct tactaatact
    67801 ttaccttctt ctagttcttc tatctctgta taataagcta atgattctac taaatctttc
    67861 ttatcattag ttttaaaaac agcctcaatt ttgtcacata caaatccatc ttctttgttt
    67921 gactttatat caactaaatt gtgatttcta aatttatctt tatctatttt ctttcttaga
    67981 ttgaagtata aaataccttt ttctccattt actattggga agtttccatc tggagaaaat
    68041 gcaaattttg gctgttcatt gacactaaag taatgctcca tacattccca agtcgtctct
    68101 tcagctccac ccactatcaa tctaatcttt ctcttcggct tttcattaag ttctcttaag
    68161 aaaagtaatg catataaaat ccctatcaaa ggtcctttgt tgtcattaac tcctctacca
    68221 taaagatagt tatctttttg acatacttta aaaggtttac tcttccaaag ttctttatta
    68281 tatattggca ccacatctat atgattaagc acccctacta cttcttctcc ttctccatat
    68341 tctatatgaa ttgcatatcc atcaaagtct tttacaacaa aatctttgtc ttttgctatt
    68401 tgaataagct tatcgaaggc atttcttatt tctatcccaa atggttgatt tatatctgtt
    68461 gtactttcat ctctaattga aggtatttca actaaacttc taatatcatt tatgatattt
    68521 tcttgattgg attttaaata atcaataatt agttctttgt ttactatcat cttaattatt
    68581 tatcacccct ttatattaat tttacaaagc atttcagttc atatctacat tataaatttt
    68641 gaatattatt ttttcaatat ttcaaatact tctctaagtt accataatga tacggtaaac
    68701 aatcaacaga ttatgacaaa atcatactat acctattact aatattttaa cttatctatt
    68761 acgtcttttt taatgtaagt ttattccaaa aatacataaa aaaagatgta gccttagcta
    68821 caccttctta tatctattca acttccatta ttatgctatt aatatctaca tttccaggtt
    68881 ctatcctatc ttttactgtt ctcttaacag aatcagcatc atccattata actacaggag
    68941 ttattatatt taaatcattt gacgttataa aatctaaatc tacttccatt attaaatctt
    69001 tagcttttac cttatctcct gcctttacct taacatcaaa cggctttcct tctagtgaca
    69061 ttgtctctaa acctacatgt attaatatat ttgtattatc attactctta atcattattg
    69121 catgctttgt atcaaataca ttgactattt caccatcaac aggagaatat aacttacctt
    69181 cacttggtat tattgctact ccatctccca tcatcttttg ggcaaaaact gcatctggaa
    69241 catcttctaa gttcactaaa tttcccttaa aagggctata tattttctca atcttatttt
    69301 cttttttctt aaatatatta aacataacac actctccaca ttataaaatt ttatgataat
    69361 atttttctta aagcttttgc tacaccatca tttacattag tatcagttac aaaatctgcc
    69421 atagatttta cttcatctgt agcatttccc atagcaatac caagacctgc aaatttaatc
    69481 atggatatat cattttcatt atcacctata caaataactt ctttgctatc tatacctaat
    69541 atatcacaaa attttttaac tgcaatacct tttgaagtac ctttactcat aacttcaaag
    69601 tttatctttc cagaacttac tacttctaaa tcttcttgtt ttttaaattc ttcctttgct
    69661 tctctcaaag aatctacgtt ttctgagaaa agtatacatt ttaaaatttc attatcagct
    69721 ttttctaata aagtttcaca acttgcattt tctattattt caattctgtc ttcttcttta
    69781 tttttactat ttattaatct atatggatgt tcttcaccta tttcattgtt ggatataact
    69841 attttacagc ctttaaaatg tttgcttaaa ttatactttt cacctattgt atagattttc
    69901 tttagagctt ctttgctcaa aaccttctta tactcatatc ccagtaattt aaaatatgtc
    69961 ccattagttg atataatata tatatcatcc cctaaaacac ttgtaaaata tttcatagca
    70021 ttataaggtc ttcccgtaac taaggctacc ttgataccct tttccatgac ttcttttagt
    70081 gctttaatat tttcttctga tacttcaaat cctttaccca tcaaagtacc atccatatca
    70141 gtacaaatta atttatatcg catttgtatc acatcctagt aagatttttc taatatttca
    70201 acaaggtctt ctttctttcc aaaaggtaaa aatcctaaaa ctggacagct tgttatttgt
    70261 tctaattgtt cctttgttac attaaactca gacatttttg tcttaagtcc cactctcttt
    70321 aaaaaacttt ctatttcatt tcctaaagtt ttagctgctt catcatcttc cactttttct
    70381 aattcttggt ttagcattct cgctactttg gcaaatttct ctatattatc cttatagaac
    70441 ttttctgcaa attttgggaa cactatagcc aaagcctcac catgaggaat atgtgtaact
    70501 cctcctatta tttcacttag tggatgtggt gctgctgctc cagcatttgc cagtgaactt
    70561 cctcctaatg tatctgctac tgctaacttt gttctgtatt ctatattatt tttatcttcc
    70621 attactttag gtagatagtt aatgactaat tccatagatt tttcagacat tatctctgta
    70681 aaatcattag catttggatt tatataactt tcaaatgcat gagtaaaagc atcaaatgct
    70741 gttgatgcag taattctctc tggcagagtt aacataagct ctgggtcaac tatacattct
    70801 tttgagaaac aattttgatg aaatattgta tttttctcgc ttcctctcga tattactgct
    70861 gcttgtgtaa cttggcttcc tgttccagaa gtagttgata cagctattaa tggtaattct
    70921 ttttcactta ccttatcgta tattttaaat ggatttgtat atgtactaaa catataatcc
    70981 caatctatct tttctaaacc aaaagtcaat gctaatactt ttgcagtatc tatacttgaa
    71041 cctcctccaa cagctaaaac aacatctaca gattcttttt tagctaattc aaacccttca
    71101 tttattaatt ctacagttgg gtttggctct actctatcaa agtgtacaac ttctatacct
    71161 ttttctatta aattcaatgt aactctttta tataacttgt ctaatggctc tacatttgga
    71221 gtagtaacta acaaacattt ctttccatat tttcctatta ttctaggtaa ttcacttaaa
    71281 gttccttgtc caaaatttat tcttgatggt tgataaaagt taatcatatt tttcctccct
    71341 taaattattg ccttcatatt caaattatac atatcatagg atttttaagg caataccttc
    71401 actgttaact cttatttact aaagcttatg gcaattatta gacaatcaat gttttattat
    71461 taccatatca ttatgtaaat tttattaagt acccatgtta taattttata atcaatctta
    71521 ttgtataatt gacttaataa taaaaataga gtatatacac ttttttatga caaatagctt
    71581 aaaggagaat taaattatga aatatttgat agacagtgct aatcttgatg aaattcaaaa
    71641 gtgtttaaag tatggattta agggaataac agctaatcca tctatgtatc ttaaagagaa
    71701 agtaaacttc catgaattta ttgagacatg tgctaattta aatccagaaa tattaactgc
    71761 tgaagtcatt ggaaataatt tatacgaatt aattaattca tgtgataaga tattaaatat
    71821 aaataaaaac actataataa aaataaattt ctctgaagtt ggcttagaac ttataaacat
    71881 attaaatagt aaaggtgtaa aaactgcatg taccttgatt ttcaatgtaa atcaagcatc
    71941 attagctata aatgcaggtg ctgattacct attccctttt ataggtagaa atgatgaaaa
    72001 tgggaatgat ggtataaaaa accttacaga aatatgtaac cttatatcaa taaatggata
    72061 taatactaaa gttgttgcag cttctattaa aaatgtattc cacttaactc aagcatctct
    72121 ttgtggatgt gattatgcag ctgtaacata tgatttattt aaaaaagctt cttttaacca
    72181 gcttacaata gatggtgcca atacttttga aagagattgg tccaaggtta ataaatagta
    72241 actaagattt aggagggttt gcattgaaca aaagattatt agatattgct gaattattac
    72301 tcaacagctc agactatatt actgtagata ctattgccga agaattaaaa gttagtaata
    72361 aaactattcg taatgacctt gttattttag atgaatggct tttagagttt aatttatccc
    72421 tagataaaaa aactggttca ggggttatta ttctaggtaa tgaagatata aaacttaaag
    72481 ttattagaga tatcaatgat aaatcaaatt gtatatatgc atactctcct gaagatagaa
    72541 aaaggtatat tctaagtaaa ttatttatta aaaattctaa gtttaggatt cgtgatattt
    72601 gcaatgaact acatgttagt agagctactg tgcataaaga cttggtagtt attcaaaatt
    72661 ttttgcaaaa ctttaaagtg actctagtta gaaaaaccaa taatggagta tatttagagg
    72721 gaaaagagaa agatattcga aaagcaattt ttgaacttgc tacggttaat aaaagttata
    72781 ctgaacttaa agaaatatta ttctcgaaat ctaatgaatg caaagatacc ccttcaacaa
    72841 aaatatttaa ggagctattt aactatgatt ttgagaaatt atctcaaatc actctacaca
    72901 ccttacaagt agaaaaaagt aaccttagtg atgagtatta tataaacttc ttaatacata
    72961 tagctatatg tattaaaaga atttcaatta aaagatatat taacttatct gaaggttttt
    73021 ttagagaatt attagaacat gaatactttg aaaaatcaaa aattttatgt gctaacctaa
    73081 gtgaagcttt tgacgtagaa tttattgatg aagaggtctg ttatatcctt cttcatatag
    73141 aaggattact taaatcaata aagaaaacta ctactcttga acctcttaaa aatgaagaaa
    73201 ttacagagta taatctatct gaagcaatag ctgttcattg gggaagtata ctaaatttaa
    73261 acttaaagga tgatttaata ttaataaagt ctcttgctaa tcaccttaaa tcagttctac
    73321 acagaataaa ctatgggttt actattacaa atcccatatt aaatgatata aagagaacat
    73381 ttccttatac ttataaggct gctaaagagt ctaatactgt tatcaaacag ttgatgaatt
    73441 atgaagtcaa tgatgacgaa ataggatatc ttgctttata tttaatatca gcaatagata
    73501 gaagcaaatc tccccttaat actattttaa tatgtcactg tagtgatggt gtatctaatt
    73561 tattagtcca aaagttaagt tttgaattta atcagattaa tatagttaaa tctatacctc
    73621 tatcttctat ttcatttacg aactttgatg atgtggactt aatactaacc actgctcctg
    73681 tagactttga acataatgct gaactgataa atataaatgc tcttttaagt aagaatgata
    73741 tttctagact tagtacaatt ataaaaaaac tatattctga aaaaaataaa atattatctt
    73801 ataaataaac aaaaataggc ttgtctcaac atagagataa acctattttt cattgtctaa
    73861 atgataaaaa tatatttgat ttcatagaaa aagtgcctca tgaactaaaa aattcatttt
    73921 gagacacctc cattttttat atttaagctt tttatttaag cttttatatt ttttaaactt
    73981 ttatatttaa agtaaatttt attattttta ttgagcacaa gcattattta tattattaat
    74041 ttcttcagta ttcttaccaa actttgtagt tacaaatcct attgttttta ttatgagtaa
    74101 taaagatatc aatgaatata tagatatcat aaaattctta cttattattc cagacgctac
    74161 tattataaat ccatctagca taaataatat aactggcaac ttcagaaact taattacctt
    74221 attaataagc attgcaacta aatcagttcc accagtacta cagcccctta ttattgctat
    74281 ccctatagca gttcctacca ataacccacc tatcactcct gctactaata gattgtcagt
    74341 tatgtgagtt tgtggtatta cttttaagaa taatgggccc ataagagtta tatataatgt
    74401 ttttattcca aaacctttcc ctaaaaataa taatcccatt actaaaagtg gcatagatat
    74461 tcctaatgat atattctcaa caggcattga taagaatgtg ctaagtacga ctgataatcc
    74521 tgttatccct cctggagcta atgtatgttc tgcaaagaaa aaattaactg ctaatgccat
    74581 taaaaatgct gatattgtta tcagtaaata atcttttatc atttcttttt tcatttaata
    74641 acctcctatg attatattat ttcagtataa aaaatcaatt aaattagtct agcttcctgt
    74701 agtttttcat aaaattaatg cttccttaaa acattaagaa agcatctctt ttatcatagt
    74761 ttattatctt attctaaacc aaactttgta gctgctttat ctatagcttt tctacaattc
    74821 ttaacacctg ctgttatacc atctttatcc ttgaatattg ctgaagataa tattacaacg
    74881 tctggattac attctattaa tggctccata ttgtctgctc ttagtccacc atctattgct
    74941 aattcacact taggattctt ttcgtctatc atttttctag ctctttttac taaatcaaca
    75001 gcactctttc tccatcccca gttatctttt ccatcagttt catcaacacc atgaacgact
    75061 atttgcaatc tatctatatc atatatagct tcatcaacaa aacataatgg tgtgtaacat
    75121 ccaattgtta atcctacttt cataccaaat tctctacagt aatttattat gtatgcaaga
    75181 ggagcaccta aaaaatgttc tgctggtatt atcaacaagt tacatcctgc tgctgctatt
    75241 ttttctataa ataatctatc acaatctctt gtgtatatat ggcattctat tggtttatct
    75301 gtcactggtc ttattgcttc tattatttga tgaccaccca taagttgcat attttttaag
    75361 tcatgcatat ctgctgcatc tgaatgcacg tagtctacac ctgcatccat tgcttcttta
    75421 actacggctg atatatgacc gtaatttaca tgtgctaatc ctgctgctat ttttatgtgt
    75481 ttcatatttg tatacctcca tattttactt taattagtat taaatattag tttttgatat
    75541 ttttttaata ttttttaatc cagtattact tttatttagc attactttta ttgctgtata
    75601 tatttctttt atgaacttat tctgcttttg ttaactgtga acttattttg ctttgtaaat
    75661 taatattaca ctgatatatt ttttttcaca acactttgac tactccttaa aagtaccttt
    75721 atattgtggt aaattataga cattaattgt atataaaaag ttagtttttt accacattct
    75781 tatggcattt attgtctata ctaactcaat tgatatagct agttcattta atatataatc
    75841 agactataaa tataaattta ctcgataaaa agtaccattc ataacaatat taatgaaagg
    75901 gagatgtaaa atgagaaact gtattattgc ccaatctgga ggccctacag ctgttatcaa
    75961 tgcttctgca gttggtattt atgaaaaaaa tttagaaact aaatactttg ataaagtata
    76021 ttttggtatc aatgggattg aaggtatatt aaacaaaaat ataatagatt cagactcctt
    76081 aaacaaagat aatgtattaa atttaaagca aacaccttcg tctggtcttg gttcttgtag
    76141 atacaaactg gctgattata aaataaattc ttatgattat gatagagtta taaatatact
    76201 agatgaatat gaaatagata cattatttta tataggcgga aatgattcta tggacacagt
    76261 gatgaaattt tctcaatact gcaaaaacac tacttgtaaa ataaaattta taggtattcc
    76321 taaaacaata gataatgatt tattaggaac tgacaactgt cctggatttg gttctgctgc
    76381 aaagcttatt tctacactaa taatggaaac atacttagat ttttctatat acaaaaataa
    76441 tggtatattt atagtagaaa ctatgggtag agatactgga tggttagcag cttcttcttc
    76501 actagctaga cttaatgata ctccacttgt tgatttaata taccttccag aaattgattt
    76561 ctatgaagat aagtttatag aagatgttag aaaaatattt aaagaaaaaa ataaggctta
    76621 tatagttgcg tcagaaggta taagggataa atacggcaac tttatatgcg aacaaaaaac
    76681 ttctgctcat gataaatttg gtcattccca attaggtgga gtaagcaact atctaaagaa
    76741 tcttatagta tcatcatcaa ttacaacaag agtaaaaacc ttagaacttg gtgtaataca
    76801 aagatgtgct atgcatttag cttcagatac tgatttaaaa caagcagctg aagttggtgc
    76861 atatgggata gaactatcta aaaaaggata tacaggagtt atggctatca ttaatagaac
    76921 atgcaataat ccttataagt atgaagttag tcatactgat atttctaaaa tagctaacaa
    76981 gacaaaatat tttcctaaag agtggataaa tgaagaatgt aattatataa ctgatgaagc
    77041 cctaaattat ctatatccac ttattcaagg taaaccagat atcaaatata aaaatggact
    77101 accttatttt tcaattattt actaggaaat tattataatt tgatatacac tcaattctat
    77161 cgctcttaaa tacctaagtg gctgttaaat aaaattataa attgttatat gacagtcact
    77221 taatcgttta attatttaac tgtttagttt tttaattttt taatcttttt taatactaat
    77281 acgatttgtt gtaataatat ctcacaccca ttttcatttt ggatagatta taattagtta
    77341 gacaataaat attttgtcat gatattatta tatatagtga tacaaataga aatactttta
    77401 tcatggctag aaaaacaaag attacacaaa ggatttaaaa atcaaacaac ttcaattaaa
    77461 ataaatggtt aaaataactt ctaaatcaac tactataaac aataaaagaa cataaagtag
    77521 ttaagtctac aattataaaa ttagtaagac tataataact taaataaaat taaagttaac
    77581 aaagactatt aaagttagca aatattcctc tacctaaata attgcttttt ataaagagtt
    77641 atttatttta attgaattta attgaaatac gattttaact agaacaatag attaatgtaa
    77701 tatttaatat aaaataatta taataattga aaaggaagta atctatgatg aaaatagcag
    77761 tcataacaac cgaattttta aaagagtttg tagataattc tataaaaaag ttaaatatta
    77821 atgcagaaat tgaaatatat atctatagag atttttctca tgttggagat ttatatttag
    77881 aaatagaaga taggtttgat ggatttgcag ttagtggccc catccccaaa aaagctatta
    77941 caaaaaaggc tggaactatt aaaaaacctc tagttgattt tggtactgac ttacaaagtt
    78001 actatgatat gtttctaaag cttatcttta aatataatac attagatttt tctagagcgt
    78061 actttgactt aacagactgg gcagataatc caaaagatat atcatattat ttatcaaatg
    78121 gcacatttgg agacttaatg gatagtattg atgaaaatgc atctaaaatg agtttatctg
    78181 acatagcaaa acttgaaaaa aagattgcaa aaaaacatat taatctatgg aatgaaggga
    78241 aaatcgattt ttctactact cgttttagta gtattgttcc tatgttacaa aatgcaggag
    78301 taaactttca tttcatatac cctgatatag atttattaaa aaatactttt aataacttaa
    78361 taaaagatat tcatttacat agaatgaagg gaaatcaacc aagtgtaata tatataacag
    78421 ttaaagatac aaattatgat gactctactc tagaccaagt ttataaaata ttaaatagta
    78481 ttaaaaaaga taaattaacc gattttataa ttgaaaaaaa tagtaattct tttaaaattt
    78541 tcactaaatg tgaaacgatt aaatcattaa ctaaaaattt tactgcatgt tatataaaag
    78601 aatctattga aaatagtaca aatattaaag tatgtgttgg atatggaatt ggtaatgata
    78661 taaagcaagc tatgtctagt gccataagtg ctaataagga atctaaaata aatcatttaa
    78721 attacagttt cttagtcaac gaaaattatg agacaatagg acctttactg tgtgataagt
    78781 tacttactgt ttcaaataaa gtaactccac atataaatac aattgccaaa agttctaaat
    78841 tgtctactct tactattcaa aagattatat ctgttactga aattctacaa agagatgaag
    78901 ttactcctaa ggaattatct tcatgtttaa atgtaacagt tagaactgct aatagatttc
    78961 taagtagtct cttaaagtct ggaaacgcta ctatattata tgaaaaacaa aactcaacaa
    79021 aaggtagacc tgaaagagta tacaaattat ttatatcaga aaataaatat taaaatccaa
    79081 aatgcataaa aatattttat catctaatat taagtaaaat tatatatgac tttctaaaag
    79141 gtatatcttt gcatcttttt aagatatacc ttttataata tttaataata ttttatgtta
    79201 ttatctacta aaattatttt ctaaccattt tactgcacaa tgagcaaata aagctgaacc
    79261 ataaactaat ccctcttcat taaaaattgc tttaggatta tgcataccaa aattatatcc
    79321 ctgactaata cttcccattc caatccataa aaatactcct ggaaccctta gtaaaatctc
    79381 tgaaaaatct tctgaaccca ttgcagatgg aaagtctatt acattttcat ttcctataac
    79441 ttctttaaca taagatacaa tctcatctcc tacatccaaa tcatttataa ctgcaggagt
    79501 ccccatttta aattccactt tagcatttcc tccaaatgat ttagctattc ctgtagatat
    79561 ttcaataatt ctatttttta atttttctct aacagattgg tcaaatgttc ttaaagtacc
    79621 tgacatagat gctttatttg gtatagcatt tggtacgctt cctgcattaa acataccaat
    79681 agttaaaact acaggctctt tctgaggttt ttctcttgaa agtatagtgt ttaatgctat
    79741 ttgtatatgt gacattatgt ttattgggtc cactccaaat tcagggcttg ctccatgagt
    79801 tgcttttcct tctactgtta tttcaaatat atctgcagat gccatagctg gaccacgtga
    79861 ataagctact tgacctgtgt taagaaattt acccaccata ctgtgaaatg ccatagctgc
    79921 atcgacctga ggattttcta atataccatc atcaatcatt gattttgcac ctctggtagt
    79981 ctcttcatct ggttcaaata caaactttac tctaccttta agtaagtgct tattatccat
    80041 aagtatttta gctgctccta agagcattgc tgtgtgatta tcgtgtccac aactatgaga
    80101 tgcatcttta ttcttacttt taaaaggtaa atccgtctcc tccataatag gaagtgcatc
    80161 catatctgcc cttaataata aggtctttcc accattttta ctgtctaaaa cagctactat
    80221 tccattatta gacgtcaatt tcggagaata tcccattttt tctaaagtac tggtaacaaa
    80281 ggttactgtt ttcggtagat tgcaaccaat ttcgggattt tcatgtaaat atcttctcca
    80341 tctaataatt tccccttcta ttgactgcgc ttctttaaaa aaatttttca tattccttcc
    80401 tcctaatcag atagtcagca aaatctcact ttcttttagt aatgaaatga tgctgatata
    80461 aaaattataa ttttatatat taaatttcat gtctttttaa ggagttggaa tatcatctgg
    80521 aataggacat ttatatgttt taccattcat agatttatca aattcttctt ttgccttttt
    80581 agctatctct ggattattta atattttagc tccaaacata gccataatct ttgatgcata
    80641 tatcatacct ttttctccta tagaacttcc tgcacaagat gtaaactgcc agctatgacc
    80701 tggtgctcct agattcgtac accctgtaaa aaagtatgct gtcggaacta tatgcattac
    80761 atctccaata tcagtagagc cataactatt aaagtttgta acatttcctc caccataata
    80821 tagatgagtt ccttctggca aattatattt acttatcata gccttatatt gttgtgggct
    80881 ttgtctatct aattcagctg caaaatccaa ttcctctcga gtccaaggct cttgtttaat
    80941 ctcattcata cattctgata caagatttgc taaaacatga ttgtttaaag tattataaca
    81001 ccctcctaaa aactctactt caacttcagt ttcagtcatc attgcagctc cttttgctac
    81061 ctttacaagt ctttcatatg tactttctac agcttctcta cttaaagctc ttgtataata
    81121 ccatactgat gctttatcag gaactatgtt gggtgctact cctccatctg taattgtata
    81181 atgaatcctt acatcagaag taacatgttc tctcaaataa ttagctccca cattagtaag
    81241 ttccacagca tctagtgcac ttcttccatt ttgagggtct gagcctgcat gtgcagtctt
    81301 tcccttaaag tgaaacttta cagagttaac agctgttgaa gtaccaattg tagcttcact
    81361 aattttattt ggatgaaaat ttatagctaa gtctaaccct tcaaacgctc cacctctagc
    81421 cataaatcct ttacctgtta attgttcttc tcctggacat gcataaaata ctatagtccc
    81481 acttaagtta ttttctatca tctctctttt aagccctact actgccccta catgtgctgt
    81541 acataataaa ttatgcccac atccatgacc atatgcaccc aattcaaatg cttcttgttt
    81601 tgttgaaact ttttgattta aaccaggtaa tgcatcaaat tctcccataa aacctataac
    81661 tggtttacct gaaccaaaac tagctctaat agccgtggct aaacctccta cacctacttc
    81721 cacatcaaat ccttcacttc ttagaaagtt tgctgtattt tcacatgctt taaattcttt
    81781 aaatgctttt tctggatttt cccatatttt cttacttaaa tcatcaagtt tgaatctttt
    81841 tttatctatc tcatttatag atatacttcc tatcattttc tattcctcct ataaatctat
    81901 ttactatcaa ccaaatataa ttggacctat tatactagca aatgccactg atgcaatggt
    81961 tacagtaaca aatcctccta taatcatctt tggtaataaa taatctgttg ccctttgttt
    82021 ttcttcttca gttccttcca tagcatcaat accttcattg gaaattatct gtgttgcagg
    82081 ataagctagc atacaagtta caccaattgc agctgacatt cttggagaat atcccaatag
    82141 ttttcctaca attgcagtaa atagtattat aaatacagag cctacaacaa gtattcctat
    82201 agttggaata atcatcccaa acaatgctgt tggagttacc ttagcaagtc ctccaggtaa
    82261 catcaacata caaccaaaca ttataattcc attagattga gatttatcta aaattccttt
    82321 ttctaaaaaa cctattcgtg taaaaatcaa ccctactaac aaacatgcta tgttgggatt
    82381 taaataatag tttgcagggg taaatcctgg tattaaagta gccaatccta caaaattacc
    82441 aatcatagca acaaatgaaa gctttgcaag atatactaaa gtagatgatt ttttacctaa
    82501 atcttcttta aaaattctca tacttggaag tttaaaatta ctttttgact catctttcaa
    82561 aaaatccccg ttatctcttt taaattttaa ttctttattt atacaatatg tagttatcgg
    82621 aatgccaaag aacttttgaa atgataatac tagaattaca aatgcagcaa gttcaggtct
    82681 atttgcagct tctgcaacag ttgttacgat aataccagca acagtagaac ccgctattgg
    82741 aggtgctgct attaaagcat actctctacc aaataacata ctacccactg ttaaacagcc
    82801 aacccctatt cctacaatac ctactaatgc aattacaacc gttttccatt catgacataa
    82861 gtcttcaaga tttataagtg ttcctaagtt agttattaat aaagctatac caaagttgct
    82921 cattgcagct aatatccctg atgctcctgt aatgtctttt ggtaaaatat ttgtccaaaa
    82981 tcctagtaaa aatataatac atacaaataa caatgttgaa attgcacctt ttgttttctt
    83041 agataaaaac tcactaaaag cataaatcat tacacataca gtaaagcaag taagtggatt
    83101 ccaaaaattt tccattgttg tttcctccta aatataataa ttttttatca ataaaacaat
    83161 aattataaaa tgtatattat gcagttattc ttaactacat atggtatagc ttgatatttt
    83221 ttgatgatat tatatacgtc ctaaattatt cctaaaatat ctaaataaat ataactagag
    83281 ttaactctct aaatattaac tatagttatc aacttactag atttcttttt gatttttact
    83341 ttctacataa ttttacgagt tagaattgta cttcaactat tctctatatt agtatacatg
    83401 ttggaagact tatatttatt taaatattag atatagaata tatttttata aacgtcttaa
    83461 attattctta aaatatctaa aacgaaataa taatataccc attaaaccaa tattatcaga
    83521 atatacttca ctttaagtct tctttatata gaaattttat ctattagtgc atcccctccc
    83581 ttgtaaatta gactatttct aagcgaattt agatatctta ttcctagaga ctattactaa
    83641 aaacaaaaat tatttattat attaaatcaa tgataagcca tactttaaaa ttctttctat
    83701 acaagtataa tttatcatat aatgacatct atacctttat ctttatagta gtcctaaatt
    83761 attcttaaat tgacaataaa aataatttca ctatttataa aaatacttgt ttttatattg
    83821 tcaaactatt cttaatatag attataattt taaatctttt ctttgtcaat atattctgac
    83881 atttttccag aaaatttata aagttatata gtgagtaaat catactattt ttatataatg
    83941 agtaaattat
//
LOCUS       DAEPID010000007        81267 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.007, whole genome shotgun sequence.
ACCESSION   DAEPID010000007 DAEPID010000000
VERSION     DAEPID010000007.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 81267)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 81267)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..81267
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.007"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            <1..2228
                     /locus_tag="KR257_000527"
     CDS             <1..2228
                     /locus_tag="KR257_000527"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729234.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=3
                     /transl_table=11
                     /product="GGDEF domain-containing protein"
                     /protein_id="HBH0029254.1"
                     /translation="SRYKKNSLVLSIILCSLIISILVITVFNTVKLHNISNKQSKNYL
                     NDVSTQIVMNVDSKIKFILSDLRIMADFIKQYEGDSRYEYLSKRKTSYKYYDVGIIDL
                     EGKAEFLSGKKFDLKNTVSYKKGIEGKEYSEVIESMGFVLYSVPIFNDNHEVSSILIG
                     VSNKESMNEILNIDNFNGKGTIEIINSKGKPLFIGKNTELIKDLSHKYKSSGDEPWAQ
                     KMLEDFKNDKSGNITITSSKGVQCLLTYHPITRGLNDWHFLLIVPEDAVLGELNKLNS
                     FTITMTFIITCIIGIITLILYIIRRKYVNQIENIAYLDSITNGINSTKFSMLVKPLIS
                     ESPDSTYMMIAMNIKDFKLINDCFGSEKGNMTLKHLYNILYKNIDENEEFVCRHDADL
                     FYLLIKNRPVLEALELLYKIEADTNYFNKNRENPYFLRLSVGIYTIENHNEDLITIQD
                     HANTARKSFNKTHQSDFSFYSDIERKRLISEKEISNLMEKALENKEFFMCLQPKIDIK
                     SGKISGAESLVRWKNSEKGIIYPSDFIPLFEKSGFICKLDLYILEETCKLISKWIKEG
                     KEVLRISVNVSRQHLNDKLFLEKYKHICNKYNVPTCLIDLELTESIFLENPEAIDIIE
                     DIHSNGFKCSIDDFGFGYSSLGILKDFKVDIIKLDRSFFVSKNNIDRGKVVIKSIIEL
                     SKRLGMKVTAEGIEELEQVEFLKNVGCDYIQGYVFSKPLLISDFENFAYENNKIKNIH
                     Y"
     gene            2484..4514
                     /locus_tag="KR257_000528"
     CDS             2484..4514
                     /locus_tag="KR257_000528"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420949.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIA"
                     /protein_id="HBH0029255.1"
                     /translation="MISGRMLLIMNFLKGKNKTSYKDISKQLSIEERKVRYDINNLNI
                     VLRSLNKSVIQKMNKGVLIIPDDFQVVCINNNEYVFSLTERVSIMKIISMFKIDNLNL
                     EKLSKEFQVSRSSIKNDLNVLSSELERNQITITYDKSFKISGEEDIIYKQRLNILKSY
                     SYLFGKEKSDLSVFEKYLVNVIEKIFKGIYLIDIYNWSMNLLLQMGWTLNDESFTWYV
                     SNIFLFTWYIHSDEKHPLESASLSEPCFENKFDQEFETIIQKKLTKEQIFLLKSFVFF
                     TNKYASLNEDMDLISTEIIVQDLIYNMSEILEISFKEDMILYKGLLNHIAPLIERIKQ
                     NIQIYEELLHVIPDKYQYVLEATKVSIQKNRVLSQIKNENETILLAIHFLGSIHRNER
                     NNYKNILLVCGFGYGVIAMLKDSLVNDYQINIVESIPSYKLQDYKDWESIDFIITTSK
                     IVIDLPKTIIEINPFLQEEDYLKFEEKGIKRKNVLTNYMSIKKRLDFLEEDAQKRVLS
                     IICQELGYSDERILFRQLNLSDLIGIDTIRIIDGDMKWEDAVKFSSNILANCDFVSAQ
                     YAENIIDILKNVGFYAVKDNEFALLHGNDSSLVKVSSISLLICKEAVSFGDKKVKIIF
                     CLASRDKKEQIPAIINLTKMVYKTNFIAMLESAKTKEEAEVLIHKYEKEVTV"
     gene            4511..4963
                     /locus_tag="KR257_000529"
     CDS             4511..4963
                     /locus_tag="KR257_000529"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888039.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIA"
                     /protein_id="HBH0029256.1"
                     /translation="MNKLVNVKCSFKIHVNSKEEAIISLVDVVSKEGYLIDKNQFLKD
                     VLKREETLSTYIGHGIGLPHSQSVGVKNSCITIGKLDTPIEWTEEGEKVDLIFLISVT
                     KDNENNLHLKILSKLARLLMHESFRNQIRCSDEQTVYNLIKEKIEEED"
     gene            4965..6020
                     /locus_tag="KR257_000530"
     CDS             4965..6020
                     /locus_tag="KR257_000530"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435041.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS fructose transporter subunit EIIC"
                     /protein_id="HBH0029257.1"
                     /translation="MRILKFLQKHLMTATSYMIPFVVAGGILFALSVTLSGQAAVPET
                     GWLAKLNQIGAAGLALFIPILGGYIAFSMADKPGLAPGMIGAYLAKEVNAGFIGGIIA
                     GFIAGFVVLQLKKIKLAPTMRTLGSIFIYPLVGTLITGGIIVFLIGEPIASFMTWMTN
                     WLNGMSGVSKIPLGGILGGMIASDMGGPINKVAATFAQTQVDTLPYLMGGVGVAICIP
                     PIGLGLATLLFPKKFSKEERDSGKASLLMGCVGITEGAIPFATSDPVRVIPCIMAGSI
                     VGNIMAFLLGCLNHAPWGGLIVLPVVDNRLGYIASVLTGAVVVAVLMKLVKKDVKEDE
                     EIEEDLDESIELIFEEL"
     gene            6087..6395
                     /locus_tag="KR257_000531"
     CDS             6087..6395
                     /locus_tag="KR257_000531"
                     /EC_number="2.7.1.202"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425302.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS fructose-like transporter subunit IIB"
                     /protein_id="HBH0029258.1"
                     /translation="MKIVAVTSCPSGVAHTYMSAESLELSAKKFGIEIKVETQGSSGI
                     DNELSLKDIDEATCVILTNDVEIRNMERFKGKKVVRMSVSEIIKKSDALIKKIKDTFQ
                     "
     gene            6499..7764
                     /locus_tag="KR257_000532"
     CDS             6499..7764
                     /locus_tag="KR257_000532"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895305.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="class II D-tagatose-bisphosphate aldolase,
                     non-catalytic subunit"
                     /protein_id="HBH0029259.1"
                     /translation="MKKLPIKTVVQRLLNLQEEGKSATLLGIGPMSPNLLQASFELAK
                     DDDFPLMFIASRNQVDADELGGGYVNGWNQETFTKDIKKVADKVGFDGLYYLCRDHGG
                     PWQRDKERNDHLPVDEAMELGKKSYLADIEAGFDLLMIDPTKDPFEIGKVIPLDVVLE
                     RTVELIEYCENERKRLNLPDIGYEVGTEETNGGLTSTETYETFITRLKVELDNRGLPM
                     PTFIVGQTGTLTRKTEQVGTFNFRNAYDLAQMAKKYGVGLKEHNGDYLDDVTLLEHIP
                     SQIIATNVAPQYGTEETRAYLKLAEVECKLEKEGLVEKTSNIRHVLLVNAIECGRWRK
                     WVVGEQKNLTTEEIFKDEVLSNEILDIAGHYTFNNDDVKKEIEVLYDNLSKNNIDGQR
                     FVVDHIKRPLRDYAECYNLKGVTTRILNK"
     gene            7852..8568
                     /locus_tag="KR257_000533"
     CDS             7852..8568
                     /locus_tag="KR257_000533"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009901731.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HAD family hydrolase"
                     /protein_id="HBH0029260.1"
                     /translation="MINLIFDVDDTLYNQLTPFYTAYNKVFSSIKDISIEDLYMSSRK
                     YSDEVFHMTENGEMPIKEMHIYRIMKAFEELGNSITEKDAQSFQDEYIYQQSQITLIP
                     EVERILNFSKERNINLGIITNGPSNHQRMKLKQLNIENWVDKSNIFISSEVGFSKPDT
                     NIFRVAENVMNLDRENTYYVGDSYRNDVLGAKKAGWKSIWLNHRGHEVEELFYKPDFV
                     ILEHKDLISLFIKICSYKNM"
     gene            complement(8763..9056)
                     /locus_tag="KR257_000534"
     CDS             complement(8763..9056)
                     /locus_tag="KR257_000534"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420959.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="spore coat protein"
                     /protein_id="HBH0029261.1"
                     /translation="MRNMIENLIKNNTYIDDKVIMLSMLSSAKASANMYLNSALTSST
                     PELRAIYSASLTQMVEGHTALTELSINKGWVKPYDKPIQQLTCSYKESQNVID"
     gene            complement(9062..9277)
                     /locus_tag="KR257_000535"
     CDS             complement(9062..9277)
                     /locus_tag="KR257_000535"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860675.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0029262.1"
                     /translation="MRILSETEKISLAAVIKMESDGLLMQRAINMLISDEDLKRQSES
                     SILATEGRIKAMQQFIVENEILISEEV"
     gene            9726..10124
                     /gene="tnpA"
                     /locus_tag="KR257_000536"
     CDS             9726..10124
                     /gene="tnpA"
                     /locus_tag="KR257_000536"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011291581.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS200/IS605 family transposase"
                     /protein_id="HBH0029263.1"
                     /translation="MYKSNKNIVYDCKYHIVFCPKYRKPVLVGEVEKMLKEILPYKAD
                     ELGAEIIEMETDKEHVHLLISCDPQYGIHKVVKGLKGFSSRVLRENFPHLKSSMPSMW
                     TNSYFVGTVGSVSLEVVKQYIENQQVRTKK"
     gene            10121..11284
                     /locus_tag="KR257_000537"
     CDS             10121..11284
                     /locus_tag="KR257_000537"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435058.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
                     /protein_id="HBH0029264.1"
                     /translation="MIKTHRVKLNLTRTQFELVREKQMESANCWNYIVNLSKEYYFEH
                     KQWIKKNDIQKLIKGKYNLHSQTIQAISDKFDANRKTISELRKKGNTKAKYPYKTKKF
                     YIIPFKASAINRNAKGNLKLSMSKGRYLELDFNVENIKTAEIVWRNGYYLYYTFDNEL
                     NGVVAKGTNTVGVDLGEIHSIASVTNEGVGLILSNREGRSIKQFRNKMYAYISKRLSK
                     CKKGSRQSKKLWRLKNKIRSKTDNQLMNLYHQTTRKFIDFCVEQKVCEIVLGDIKGVE
                     KDTKKKKRLNRVNRQKISQMEYGRIKDYIKYKAKEQGIEVKLVKENYTSQTCPKCSKK
                     HKPTGRTYSCTCGYETHRDIVGAWNILNKKHKYGLVDFRINHKQPINLKVSTV"
     gene            complement(11668..12180)
                     /locus_tag="KR257_000538"
     CDS             complement(11668..12180)
                     /locus_tag="KR257_000538"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895309.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nitroreductase family protein"
                     /protein_id="HBH0029265.1"
                     /translation="MLEVIKNRRSIRTYIDKNIEEDKITEILKSAMQAPSSKNAQPWE
                     FIIVDDKELLKQLSKSQHRAKHIEFAPLCIVVLGNRDKFLKPGKWIQDLGACTQNLLL
                     EVTNQGLAACWAGVFPKNKVVNKVRQTLDLPLKLVPYALISIGYSEEKNEFIDRFDEN
                     KIHRNVYKNR"
     gene            12630..13106
                     /gene="purE"
                     /locus_tag="KR257_000539"
     CDS             12630..13106
                     /gene="purE"
                     /locus_tag="KR257_000539"
                     /EC_number="4.1.1.21"
                     /EC_number="5.4.99.18"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425290.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="5-(carboxyamino)imidazole ribonucleotide mutase"
                     /protein_id="HBH0029266.1"
                     /translation="MKVAVVMGSKSDYPKLEEGIKLLEKYGIEVVARALSAHRTPEQL
                     SIFLKEIEDDTDVIIAAAGKAAHLPGVIASQTLIPVIGLPIKSSTMDGLDSLLSIVQM
                     PKGIPVATVTIDLGLNAALLALQIMTLKYPKLKEDLKSYREEMAQKVLEDDKNLRG"
     gene            13112..13810
                     /locus_tag="KR257_000540"
     CDS             13112..13810
                     /locus_tag="KR257_000540"
                     /EC_number="6.3.2.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007285750.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphoribosylaminoimidazolesuccinocarboxamide
                     synthase"
                     /protein_id="HBH0029267.1"
                     /translation="MLLYEGKAKQVYSTDNENEYVVYYKDDATAFNGEKKAEISSKGI
                     LNNKISTIIFEMLKENNINTHFIKSLSDREMLVKKVEILPLEVIVRNIAAGSICKRVG
                     LEEGVVFDEPIFEISYKNDAYGDPMLNDDYAVAMKLATREELKFLREETLKINELLKA
                     FFLKLNLKLVDFKIEFGKDSEGNIILADEVSPDTCRLWDVNTNEKLDKDRFRKDLGDL
                     VEGYTEVLSRMNNK"
     gene            13822..15189
                     /gene="purF"
                     /locus_tag="KR257_000541"
     CDS             13822..15189
                     /gene="purF"
                     /locus_tag="KR257_000541"
                     /EC_number="2.4.2.14"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425288.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amidophosphoribosyltransferase"
                     /protein_id="HBH0029268.1"
                     /translation="MCGVLGIYSNKDVTKELYYSLYSMQHRGQESCGLALLDDGEIKY
                     KKDMGLVGDVFKENELSKLKGNIGIGHVRYSTAGGSHVSNCQPLVGSCRKRQLAIAHN
                     GNLVNANYLKDMLEEDGYMFQTNSDTEVILYILARYYKGDIVESLKVTMDYIKGAYAL
                     VIMSQEELVAVRDPHGFRPLVLGKKGDEYIFASENCAIDILGGEVIRDVEPGEIIVVK
                     DGELKSYFYSENYKPVKKSCIFEHIYFARNDATIDNVNAYEFRIKCGERLAQNETVKA
                     DMVVPVPDSGWPGAIGYANASGLKISEGLVKNRYVGRTFIKPTQEEREIAVKIKLNPL
                     STIIKGKSIILVDDSIVRGTTSKQLVKSLREAGAKEIHLRITSPPVAYSCYYGIDTPN
                     RSKLIASSNNVEEMREYIGCDSLKFLDIEGMLDATEHKSTFCKACFDGEYPVKKIDKE
                     ELLSC"
     gene            15183..16259
                     /locus_tag="KR257_000542"
     CDS             15183..16259
                     /locus_tag="KR257_000542"
                     /EC_number="6.3.3.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895312.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphoribosylformylglycinamidine cyclo-ligase"
                     /protein_id="HBH0029269.1"
                     /translation="MLTYKESGVDIDEGNRAVDLIKGKIKGTYDGNVVGDLGNFSGLY
                     SLKDFVGMKEPVLLASTDGVGTKLKIAQMMDKHDTVGIDLVAMCVNDLICQGAKPLFF
                     LDYIALGKLVPEHIEKIVGGIADGCKMSGCALIGGETAEMPGMYGEDDYDLAGFSVGI
                     ADKEKIVSGNNVKSGDVLVGISSSGVHSNGFSFIRKIFLETYNYKMEQYVEELGMTVG
                     EALLTPTKIYVKLALDVLAKHDIKAIAHITGGGLIENITRVIPKGLGLDINKKSWEKP
                     PIFKMIEGFNAVDERELHKSFNMGIGLVLIVDKENADDVVNFINNRENDNAAYVDKKY
                     SELLEDKAYIIGEVVDSHEGVELC"
     gene            16253..16846
                     /locus_tag="KR257_000543"
     CDS             16253..16846
                     /locus_tag="KR257_000543"
                     /EC_number="2.1.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420972.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphoribosylglycinamide formyltransferase"
                     /protein_id="HBH0029270.1"
                     /translation="MLNIGVLISGGGTNLQAVIDGTESGEIKGQVKVVISSKQGAYGL
                     ERAKNHNIKAICETDEDKIIEILKENKIDLVVLAGYLKIISPKLVNEFRNKMINIHPS
                     LIPSFCGAGFYGEKVHQGVIDYGAKVTGATVHFVDEGADTGPIIMQDVVKVNQDDDAK
                     TLAKRVLEVEHRILKESISLFCENKLKLQGRRVFINE"
     gene            16839..18371
                     /gene="purH"
                     /locus_tag="KR257_000544"
     CDS             16839..18371
                     /gene="purH"
                     /locus_tag="KR257_000544"
                     /EC_number="2.1.2.3"
                     /EC_number="3.5.4.10"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436063.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional
                     phosphoribosylaminoimidazolecarboxamide
                     formyltransferase/IMP cyclohydrolase"
                     /protein_id="HBH0029271.1"
                     /translation="MSKRALISVTDKTGVVEFAKELNKLDYEIISTGNTFKTLKENGV
                     NVMQVEDVTNFPEILDGRVKTLNPYIHGGILYKRDKESHVETVNEHKIHSIDLVAVNL
                     YDFEGTLKAGKSHDEIIENIDIGGPSMIRSAAKNYKDVIVVVDIKDYDSIIEKLKTDT
                     MTLEDRKKLSYKAFSTTGRYDALISSYFAGEVGDTYPDILNLTFQKEQTLRYGENPHQ
                     NGFLYSQSNAKNPILNYEQLGGKELSFNNLNDLHGCLEVMREFKDSEEVVSVAIKHAN
                     SCGVGLGKDAFEAYTKCYEADKVSIFGGIVGITSTIDKATAEKLNEIFLEIVVAYDFE
                     PEALEILKQKKNLRILKLAKIENSLQPYEMKYLDGKLLIQDRNNILAEKSENVTKEKP
                     TDAQLKDMEFGMRVVKNMKSNAIAVVKNGQTLALGCGQTSRIWALKNALENNKDKDFT
                     GAVLASDAFFPFDDCVTLAHEYGISAVVQPGGSIKDKDSIEACDKYDMVMVFTGIRHF
                     KH"
     gene            18382..19632
                     /gene="purD"
                     /locus_tag="KR257_000545"
     CDS             18382..19632
                     /gene="purD"
                     /locus_tag="KR257_000545"
                     /EC_number="6.3.4.13"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888045.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphoribosylamine--glycine ligase"
                     /protein_id="HBH0029272.1"
                     /translation="MKILVVGGGGREHAICWKLSKEKNVEKIYCAPGNAGIANVAECV
                     NIGDTNIEELLKFAKENEIGLTIVGPEVPLVMGIVDEFEKEGLRVFGPNKKCAQLEGS
                     KAFSKEFMIKHNIPTAKYKEYTNLEEAISEIDSFGYPVVIKADGLAAGKGVVIPENRE
                     DAIATLKEMMSDKKFGAAGDKIVIEEFLKGIETSILAFVDNDTIVPMASAKDHKKVNN
                     YEQGPNTGGMGTFSPSEIYTEELANKVKETVLEKTLEGFKKDGLNFKGILFVGLMITE
                     DGEKVLEYNVRFGDPETQSVLFRLETDLHEIMEAILDNKLKDIEINYSDDEAVCVMLT
                     SGGYPDSYEKGKIITGLENLDDDIVVFHSGTKMFDGNLVTNGGRVIGITAKSTRVKDA
                     AEKVYENIKKINFEGMHYRTDIGR"
     gene            19657..23463
                     /locus_tag="KR257_000546"
     CDS             19657..23463
                     /locus_tag="KR257_000546"
                     /EC_number="6.3.5.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860677.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphoribosylformylglycinamidine synthase"
                     /protein_id="HBH0029273.1"
                     /translation="MLNTENKDSMVRRVLVEKREGFDLEAKALKKDLVESLHIDNIEN
                     LRILNRYDVEGISEEVYENAAKTIFSEPNLDVVYYEEIPKLNDERVFAIEFLPGQYDQ
                     RGDWAAQCVQIVNQGIRPAINTAKVYILSGKITDEEFSKIKDYCINPVDSREASLEKP
                     ETLKMETEIPTTVEVLDGFIDLDENGLRTFVSEKGLAMTLGDLQHVQKYFKDTEKRNP
                     TITEIKVLDTYWSDHCRHTTFMTEIENVKIEDGKFNDIVKEAYQMYLNSRDNVYVNRH
                     KDICLMDIATVAVKELKKNGKLNDLDESEEINACSINVDVEVDGKMEKYLVMFKNETH
                     NHPTEIEPFGGAATCLGGAIRDPLSGRSYVYQAMRVTGSADPRTTLEDTLPGKLMQRK
                     ITTEAAHGYSSYGNQIGLTTGQVAEVYDENFVAKRMEIGAVIAAAPKENVVRERPEAG
                     DVIVLLGGKTGRDGCGGATGSSKEHSEESILTCSAEVQKGDAPNERKIQRFFRNKEVA
                     QMIKRCNDFGAGGVCVAIGEIADSLDINLDLVPKKYDGLDGTELAISESQERMAVAIK
                     KENKDKFIQLAVEENLEATHVATVTDTGYLRMFWNGKAIVDINREFLDTNGVKQTTDV
                     HVTKVDEENTFFSSNEIVKDVKCASMKDKFTKVLSDLNVCSQKGLVEMFDNTIGGNTV
                     LMPFGGKYQATPTQGMVAKIPVLGGETNTSTIMTYGYNPKVGKWSPFHGALYAVVESV
                     CKLVAIGGNYSTTRLTFQEYFEKLGNNPEKWGKPFSALLGAFYAQSKFEIPAIGGKDS
                     MSGTFKDIEVPPTLVSFAVDTVDAKKVVSPEFKKADSKVVMLCVNKAENDVVDFEELK
                     RNLDKVRELIHGNKVLSTYALGFAGVGEAISKMAFGNKIGFKFSEEAEKAFTDNKLFE
                     ASYGNIVLELANDDLSMLEGYNYVVIGSTVKEASIFIKGEELALDELYKAHCSTLEPI
                     FPTKTEEVKSKIETISYISQGEAKKSSLSIATPRVFIPAFPGTNCEYDSARAFERAGA
                     NASIRVFKNLTYKDIEDSIDTIVNEIKSSQIIMLPGGFSAGDEPDGSGKFIATVFRNP
                     RVQEAINEFLTQKDGLMLGICNGFQVLIKLGLVPYGEIRVPSESAPTLTYNNIGRHQA
                     KIARTRISSNKSPWLAQTNVGDIHNIAISHGEGKFVASEDVMRELIANGQVATQYVDF
                     NNEATYDIEFNPNGSFYAVEGITSADGRVFGKMGHSERIGEEVYKNIIGEKDQKIFES
                     GVKYFR"
     gene            23669..24541
                     /gene="rfbD"
                     /locus_tag="KR257_000547"
     CDS             23669..24541
                     /gene="rfbD"
                     /locus_tag="KR257_000547"
                     /EC_number="1.1.1.133"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895318.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dTDP-4-dehydrorhamnose reductase"
                     /protein_id="HBH0029274.1"
                     /translation="MKILITGSNGQLGKELVNQLEAINQSINQPKYVILATTRSDLDI
                     SNQTNVDNFILHNKPDVVVNCAAYTKVDACEDNIEIAYKINALGVRNLAIASEKVNAK
                     LIHISTDYVFNGFSKYPYREDNKTEPNSVYGKSKLMGEKFVEQFSHKYFILRTAWLYG
                     NGNNFVKTMIKLSLENKEVNVVNDQFGTPTSTVDLAKIIIRIMETEHYGVYHATCEGE
                     CSWYDFAKKIFKLKNIDIKVNPIKSNEFKCKAPRPLYSVLDNFMLKLIGLNSFRKWEE
                     SIEEYLERYDINEK"
     gene            24650..25519
                     /gene="rfbA"
                     /locus_tag="KR257_000548"
     CDS             24650..25519
                     /gene="rfbA"
                     /locus_tag="KR257_000548"
                     /EC_number="2.7.7.24"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436059.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glucose-1-phosphate thymidylyltransferase RfbA"
                     /protein_id="HBH0029275.1"
                     /translation="MKGIILAGGSGTRLYPITKCISKQTLPIYDKPMIYYPMSVLMLA
                     GIQDILIISTPRDIKAFEELFGDGSSLGLNITYAIQEKANGIAEAFIIGEEFIGNDRV
                     SLVLGDNIFYGYGFSERLENAVKRKGATIFGYHVSNPNSFGVVEFDKDFNVLSIEEKP
                     TVPKSNYAIPGLYFYDNDVVEIAKLVEPSDRGELEITSINSEYLKRGKLKVELLGRGM
                     AWLDTGTHKGLLDASNYVEVVQTRQGLYIACLEEIAYTKGYISREQLMKLAKPLIKTE
                     YGQYLLKLASEDM"
     gene            25568..26125
                     /gene="rfbC"
                     /locus_tag="KR257_000549"
     CDS             25568..26125
                     /gene="rfbC"
                     /locus_tag="KR257_000549"
                     /EC_number="5.1.3.13"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888049.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dTDP-4-dehydrorhamnose 3,5-epimerase"
                     /protein_id="HBH0029276.1"
                     /translation="MGKINVIKTKIEGLYIVEPNVFYDERGYFMESYNKKDFIEQGLD
                     MCFIQDNESSSRKGVLRGMHFQVKYPQGKLVRVTEGEVFDVAVDLRKDSQTFGKWEGV
                     ILSDKNKKQFYIPEGFAHGFLVLSEKAVFSYKCTNYYYPEFENGFIWNDKQISIEWPL
                     KGIEEIFLSEKDKKQKSFKDICTRR"
     gene            26163..27146
                     /gene="rfbB"
                     /locus_tag="KR257_000550"
     CDS             26163..27146
                     /gene="rfbB"
                     /locus_tag="KR257_000550"
                     /EC_number="4.2.1.46"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009904815.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dTDP-glucose 4,6-dehydratase"
                     /protein_id="HBH0029277.1"
                     /translation="MKKILITGGAGFIGSNFIHYMLNKYVDYFIVNLDLLTYAGNLET
                     LIEIQDNSNYKFVKGDISNREQVYKLFEEERFDIVVNFAAESHVDRSVENPDLFIKTN
                     IIGTQVLLDASIKYGVKRYHQISTDEVYGDLPIDRKDLFFTEQSSINPSSPYSASKAS
                     ADLLVSSYYRTYGLLTTISRCSNNYGPYHFPEKLIPLMILNALENKQLPVYGNGENVR
                     DWLHVYDHCTAIDLIIHKGNIGEIYNIGGHNERSNLEVVKMILNLLGKSEELISYVND
                     RPGHDLRYAIDATKIENELGWKAKYDFDLGIKETVKWYIENESWWKAVLSV"
     gene            27176..27844
                     /locus_tag="KR257_000551"
     CDS             27176..27844
                     /locus_tag="KR257_000551"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420984.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="lytic transglycosylase domain-containing
                     protein"
                     /protein_id="HBH0029278.1"
                     /translation="MNEISSLINILALTQLSGSNTTNQCNCTYNNSSGFDMIMMTLLK
                     ALSQNNQHTSNSYNLLSNSENLFNELDNVVNNTTSRFIDVDTKDKNVKLRIENAVDQA
                     SKKYNVDSNLIKAIIKVESDFNPNTVSSAGAKGLMQLMPENCRDLGVTDPFNIEQNID
                     AGTRHIKEYIDMFGGSIEMGLMAYNGGPGRMKSRGVESISDLYKMPKETQNYIPKVMK
                     YYRG"
     gene            27853..28281
                     /locus_tag="KR257_000552"
     CDS             27853..28281
                     /locus_tag="KR257_000552"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860679.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YaaR family protein"
                     /protein_id="HBH0029279.1"
                     /translation="MGINIDKLNISPSINMEVKKLKESNKFSDKLNSLKQSSSLEDIK
                     RNLESVKKAGERLVLTQNYGDISIYKNAVKEYLKSVVDNMYSLDKNSSFWEHQYYKNV
                     KIVDSKLEDMTSKLISEEKENIDIVSTVDMIQGLLIDMYR"
     gene            28305..28619
                     /locus_tag="KR257_000553"
     CDS             28305..28619
                     /locus_tag="KR257_000553"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888052.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="FliM/FliN family flagellar motor switch protein"
                     /protein_id="HBH0029280.1"
                     /translation="MNSKKEDIYELNFGQLIEEKSGVIEENQNVFNAKVNVAVSIGNT
                     TETIKNILDLKEGSIIKLSKNVDEKLDIYANDRLFAYGESIITNERLSVRLSKIEDPD
                     VN"
     gene            28771..29046
                     /gene="flgM"
                     /locus_tag="KR257_000554"
     CDS             28771..29046
                     /gene="flgM"
                     /locus_tag="KR257_000554"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009901737.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flagellar biosynthesis anti-sigma factor FlgM"
                     /protein_id="HBH0029281.1"
                     /translation="MDIKNVSSNIVVNNYLKNTSGIKKVEEVKKINKTDKIELSKFAK
                     EMASVSNMSDENIRNKKVDEIKNALENGTYKIKPKEIAKKMIEDMRG"
     gene            29051..29467
                     /locus_tag="KR257_000555"
     CDS             29051..29467
                     /locus_tag="KR257_000555"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420988.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flagellar protein FlgN"
                     /protein_id="HBH0029282.1"
                     /translation="MITDLKVIIYEEKNIISKMMELLKEQFDYIVEKDLENLNMLNPK
                     LEDISRELASIEIKRRQLFGDDISMSEVVENSNDGYLKEIYTDLKHILALAKNQQESN
                     DSLIKKELIFTKKMINFIKPADKQTTTYNSYGNIRK"
     gene            29485..30795
                     /gene="flgK"
                     /locus_tag="KR257_000556"
     CDS             29485..30795
                     /gene="flgK"
                     /locus_tag="KR257_000556"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420989.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flagellar hook-associated protein FlgK"
                     /protein_id="HBH0029283.1"
                     /translation="MAGLFSILNTANSGMNAHQKAIQTISHNISNLDTDGYSRQRTEF
                     ATNSPMYMPSLSNSIARGQLGTGVHVTDVTRARNSFYDYQFRAEAHKYGKTVSKYDYY
                     NTIETILNEPSDYGISAGIDDFFKGWESLSKDINSDSKKSLVVENASNLATLISESYK
                     KLDKLKEDIDSNIDTEIKQINDMLKSLEDLNKSIDIISGSGSTPNDLLDERDRILDNL
                     SFKLDFENSDVKNMLADGKLELNELKNPDGTWKTGISGTLQGLFEMHGKIDTYKSDLK
                     DVSDGLAKQINDVYNTSAGITVTDFFITSNVDGEDIIKINPAIKSNPNELKLTADEAS
                     KIAKLKDEKIDIGVAGGKVSTISDHYKAFAESIGLDSQKVNQDEANQRKIINNIDNSR
                     MSVSGVSLDEEMTELIKIQRSYQASAKVMSTAVQLLDVVINGII"
     gene            30814..31746
                     /gene="flgL"
                     /locus_tag="KR257_000557"
     CDS             30814..31746
                     /gene="flgL"
                     /locus_tag="KR257_000557"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860684.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flagellar hook-associated protein FlgL"
                     /protein_id="HBH0029284.1"
                     /translation="MRVSTGMMSSSYLNSLQDNLQRLDKVNRQVNTTKEINKLSDNPY
                     KAIKILNSKSEIKTMETYVENCKDTGNWLETTDTALDQLGKLLSDIKKTLVASGDGAY
                     SDDELKTLSNETNEKMKEIANALNATHEGKYIFSGSNTGVPPVECIDNADGSVSLKFN
                     SSLNLNKLNDSLSMDIAQGISVDYNVKLSSLGFDPTKTDPFEELNNISKKLANPDADA
                     IKELTTTCLGDMEQLIENTVNVRSIYGTKANTVEAMKEKNDDSLIQLKDILSQNEEID
                     YGEKLVQLKAAELTYQASLQTGGKLFNVSILDYI"
     gene            31762..32154
                     /locus_tag="KR257_000558"
     CDS             31762..32154
                     /locus_tag="KR257_000558"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420991.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flagellar assembly protein FliW"
                     /protein_id="HBH0029285.1"
                     /translation="MMKVTLKKGILGFENLKEYELLDIEDNDYLKEFNSTEEEGIGFV
                     VVSPFEIINEYEIVLNQETIEKLEVKSPKDVVLFNIITLGQIFEESTVNMKAPIVINI
                     KTNFGMQIILQDDKYSIRHPLLRGDSGC"
     gene            32148..32360
                     /gene="csrA"
                     /locus_tag="KR257_000559"
     CDS             32148..32360
                     /gene="csrA"
                     /locus_tag="KR257_000559"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011987028.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="carbon storage regulator CsrA"
                     /protein_id="HBH0029286.1"
                     /translation="MLVISRKKDEAVLIGESIEVKIVGVDGNNVKLAISAPNNISILR
                     KEIYEKVKSENIKATNKNIKILKSLK"
     gene            32382..32777
                     /gene="fliS"
                     /locus_tag="KR257_000560"
     CDS             32382..32777
                     /gene="fliS"
                     /locus_tag="KR257_000560"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860686.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flagellar export chaperone FliS"
                     /protein_id="HBH0029287.1"
                     /translation="MYGENPYNSYKQNAVFMASKEQLLLMLVDGAVKYTKIAKTAILD
                     KNTQKAHRELIRVQDIFTELMVTLDQNAGQWAKDMYRVYDFVRYELSRANIRKDIQII
                     DNVLPVIEQIKDTWHEADKKSKEERSRYK"
     gene            32777..33133
                     /gene="fliS"
                     /locus_tag="KR257_000561"
     CDS             32777..33133
                     /gene="fliS"
                     /locus_tag="KR257_000561"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895325.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flagellar export chaperone FliS"
                     /protein_id="HBH0029288.1"
                     /translation="MELNLAELDKLSKEELLLMLVDGTVKYTNISKEALLNNDYLKAH
                     NELVRVQNIFTELMTTLDQDAGQWAKDMYKVYEFIKSELAIADENKDIKIIDDILPIV
                     KQIRDTWHEVYNQLKI"
     gene            33154..34677
                     /gene="fliD"
                     /locus_tag="KR257_000562"
     CDS             33154..34677
                     /gene="fliD"
                     /locus_tag="KR257_000562"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895326.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flagellar filament capping protein FliD"
                     /protein_id="HBH0029289.1"
                     /translation="MSSISPIRVTGLSGNFDMEGIIEASMIRDKEKVDKAKQEQQIVK
                     WKQEIYRNVIQESKDLYDKYLSVNSPNSIVSEKAYSSTRITSSDESIIVAKGSAGAEK
                     INYQFAVSQMAEPAKFTIKLNSSEPIVQQFPPNASGASSLTIGDVNIPISEQDTTSTI
                     VSKINSLCADNDIKASYSEMTGELIISRKQTGSSSDINLRVIGNDNLAQQIANDNGIT
                     FINDAGGNKVANVYGKNLEADVTDEHGRVTHISKEQNSFNIDNIDYNVNSKGTAKLTS
                     VTDTEEAVKNMQAFVDDYNKLMDKVYGLVTTKKPKDYPPLTDAQKEDMTTEEIEKWEK
                     KAKEGILRNDDELRGFVEDIQSAFFGDGKNIIALRKLGINESENYNKKGQISFNADTF
                     SKALIDDSDKVYKTLAGYSSNYDDKGMFEKLKDIVYEYSGSSTSKLPKKAGIEKTASA
                     SENVYSKQIAEQERNISRLVEKMNDKEKRLYAKYSALESLLNQYSSQMNYFSQAQGN"
     gene            34680..35015
                     /gene="fliT"
                     /locus_tag="KR257_000563"
     CDS             34680..35015
                     /gene="fliT"
                     /locus_tag="KR257_000563"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436034.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flagellar protein FliT"
                     /protein_id="HBH0029290.1"
                     /translation="MDKLKEKLNLYKDISLQIINLIEKEEYIKISIKLGERQEIINSV
                     SEIDRNDFIQLYNRMELIEIDSRIRDILQGQLLEVKKELHEYKLTKQVNTMYYNLNRE
                     KVNIFNKKV"
     gene            35117..35989
                     /locus_tag="KR257_000564"
     CDS             35117..35989
                     /locus_tag="KR257_000564"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860690.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flagellin"
                     /protein_id="HBH0029291.1"
                     /translation="MRVNTNVSALIANNQMGRNVNAQSKSMEKLSSGVRIKRAADDAA
                     GLAISEKMRAQIKGLDQAGRNVQDGISVVQTAEGALEETGNILQRMRTLSVQSSNETN
                     TAEERQKIADELLQLKDEVERISSSIEFNGKKLLDGSSTEIRLQVGANFGTNVAGTSN
                     NNNEIKVALVNTSSIMSKAGITSSTIASLNADGTSGTNAAKQMVSSLDVALKELNTSR
                     AKLGAQQNRLESTQNNLNNTIENVTAAESRIRDTDVASEMVNLSKMNILVQASQSMLA
                     QANQQPQGVLQLLG"
     gene            36082..38223
                     /locus_tag="KR257_000565"
     CDS             36082..38223
                     /locus_tag="KR257_000565"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888063.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase"
                     /protein_id="HBH0029292.1"
                     /translation="MLLSIVMIVKNEEKILEKTLKSLTTLRNSIESELIIVDTGSTDD
                     TIKISKKYTEKVYFHNWNNDFSSMRNISISYAKGEWLLILDADEILIDSSTIVKFFKD
                     GLDKKFNSASIQLKNLYSYDKKLYGYCSVLRLFKNVDFRYHGKVHEQPIYKNPIFNNV
                     ADFEHYGYLFEDEEIRLNKVKRNEKLLFQELKENDNSPYTNYQLGKNFIILGKYQEAL
                     YYLEKSYELYSKLELAPGYLITSLVKTYLYLGKHKKCERLCLKYIKKDMNNIDIYYYI
                     AQAQVDLGKYENSIDSYKRYIYLLDNYEISTQANSLFSDTDTVGLRDEAIITLIKIYY
                     KLEKYEFVISEYNNIEDVEKKKNVYFSLFMSLYKLNRFEDIKNYYKEVSNSKIEKNSF
                     YRNIEEVINNIKEDEKEYVYKILCDIEGNYGILNQIRINKCVSIDKCKEILNEEKEII
                     YAYIIKIAFEEKIDLLDIFYEMEYVWIEKYLKYLLALERSFNLVLYKYIISRPNTSDM
                     EKIRVYKAISKVVLESISLSDEKYKEIFYLYIMYSYKYIRYIYSNLSDFELIKFVCND
                     LDKFTIEFKHLLDIKNKVNNANEKLEYIHSMRKLLNEYPFYNKIIKILIGELEENIKE
                     SEEFKDLKDSFIISIENMIETGKINDAKLLVDDYSKTFVDDIKILNIKGILYMFENKL
                     DKADFMLKKALSLDVENEDTIYNIEYLKSLR"
     gene            38247..40124
                     /locus_tag="KR257_000566"
     CDS             38247..40124
                     /locus_tag="KR257_000566"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892587.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase"
                     /protein_id="HBH0029293.1"
                     /translation="MNIPIVVNEKSKDIIKDWQYTCTNEDIKFTSIIILTYNQIEYTK
                     LCIESIRKFTPKNKYEIIIIDNNSSDGTVEWLKGQSDIKSVYNNKNLGFPKGCNQGIE
                     LATGENILLLNNDVIVTPNWLYNLNKALWSQDNIGAVGPITNACSYYQQIDVDYKSIE
                     DMFIFAHKINKSNINLWKYRLKLVGFCMLIKKTVLDNVGVLDELFTPGNFEDDDLSFR
                     MIESGYKLLLCQDTFIHHFGSVSFKENRNKYTDIMYINRRKFETKWGFNPEYSGMIRT
                     DLISKIDDSLEANINVLEIGCGIGATLLEIKNIYKNASIYGIEISESAGKLAKYSADV
                     LIANIEKVKLDYKKDFFDYIILGDVLEHLIDPWKIVNELKQYLKKDGYLVSSIPNIMH
                     VSVLRNLVLGNFTYEDSGILDKTHLRFFTLNEITKMFNDSNYIINSITATSMPLSEID
                     NSFIDTICKESCKEMRQQYESYQYIVKASKILDTKRYSSISMINLKYALMRIDNELDV
                     DSNLSYIFDNYNITEPCFVDDIEYLIDTFVINKATLLNRLGVEAFNRGLGDFSINMFM
                     TVLEMDRDDIDSIYNITSVLCELEEFDTAYNLIKNSSEKVQSESDIQEILCFIEGKKY
                     E"
     gene            40117..42231
                     /locus_tag="KR257_000567"
     CDS             40117..42231
                     /locus_tag="KR257_000567"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892588.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyl transferase"
                     /protein_id="HBH0029294.1"
                     /translation="MNNDKICFITCVNDERLYEECLVYINSLDIPKNFSIETVALRGA
                     DSIASAYNKAMRETDSKYKVYLHQDTFIINKNFIHDILEIFKKNTDVGMIGVAGVKDM
                     PVNGIWWDSDKKAGKVYDSHTGKMDIYEFSNFEECFNEVMAIDGLIMITQYDVFWRED
                     KFDGWHFYDLSQSMEFRQNKYKVIVPKQNKPWCMHDSGVVNINNGYDEYRIKFVKEYI
                     NLDLYRENFYEFDKKKASTILKSNKHVMDCMKEELTEQLRLKNYKDVLGIVSKIAHFS
                     VFNHTGLYSCEECERALLECANNLPEIENTKLFTKKDLKRRKVLHVLSEGYSTGGHTR
                     LVKNWIEIDKDSVHSVVTTWQSDTLPDWLLKAINDSGGEVISLDLISDDYLKRAVALR
                     KIAYDWADIVILYVHMWDTIPVVAFGVDGKIPILHVNHYDSTFWLGTSIADIVIDFSE
                     TSQLITLDKRGIDKSEILPMPLKEKEVFSKSEVRKRYNLEDDVTIILTIASERKYNSV
                     NDINYFKIAKTLIENTDNTIIIVVGVDTENLYWKTLSNVTDNRVICFGTTANIDDFYK
                     ISDIYLESFMVGSHTSKLDAILYDLIPVKFKNEVSPIFTNMWNFIDKFDYKNIKEVID
                     MIRRYNTSEFDRDKIKAKQSEIKHFVIDKHCIEIKNYIDKIYNEVNHHKVKYDLYKND
                     EIEDYQLFVALYGYMVKNKNMS"
     gene            42240..43235
                     /locus_tag="KR257_000568"
     CDS             42240..43235
                     /locus_tag="KR257_000568"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436022.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptidoglycan bridge formation glycyltransferase
                     FemA/FemB family protein"
                     /protein_id="HBH0029295.1"
                     /translation="MNNIHINKFEKSCEKNWDYFVENKSINGTFLQTRNFLNYHEEGK
                     FTDHSLIICKGEEILAVVPACETYEDGERIFFSHLGSTFGGIIIRSGFNDIRHVNAIT
                     NKLEIYLQEQNFDKVYLKNTSRIFCKEDTSLLEYFLFKNNYMFYDELSMFLELSKYKE
                     DILANFKYSKRRDFKYSLKNNLTFKRLYSDEDIVCFFNLLSNCLDSKGAKVIHSVEEL
                     LEFKNNRLKDIVEFYAVYIDDIMICGSMVFNFQERVYHTQYLASNSTYNKYYPMIFLY
                     YNLIKDALERNFKYLSFGISTLNRGKYLDEGLATFKEGFGSSAICNRTYYKNINK"
     gene            43327..44559
                     /locus_tag="KR257_000569"
     CDS             43327..44559
                     /locus_tag="KR257_000569"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888065.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-grasp domain-containing protein"
                     /protein_id="HBH0029296.1"
                     /translation="MKRLMILGSIKYFENIVMSAKREGIYTIVCDNRIDTPAKKICDE
                     AIDVDVFDFDKIKNIAIDKKIDGILTGFTDSLMKPYVYIANELNLPCVISCNQLESVT
                     NKAVMKNYFKNNGIPTTDYCIIESLKDLEKIQGLNFPLVIKPVDGYGSRGVYFVSNIE
                     ELIEKFEYSKEASQDGQVIIEEFYESEEIQGLAWVHNGESHVFYIGDRELVNIHTGRA
                     GKPDRLIYPSKYCFQYEEEIKSIYQNITQAFGIKNGPLYVQMLVGAYGIKVSEVMPRL
                     PGGCDYMAISQITDLDIGSLFANFSVNNEVNFDEIKKYNMHLSKCVYALPIYIRPGTI
                     KKINNIDKIENLDYVTQFLLLVKEGDTIGLYEDERQDCGRVYGVANNVFDANIKKKCI
                     HEMIEILDENNENMIENF"
     gene            44579..45523
                     /locus_tag="KR257_000570"
     CDS             44579..45523
                     /locus_tag="KR257_000570"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895329.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ornithine cyclodeaminase"
                     /protein_id="HBH0029297.1"
                     /translation="MKLITHEQIMSLNISQKQGYEWIKESFLTKKDCQLPPKISMVEE
                     GHVFYNVMPSLNHNHKIGGIKMVTRLPGRNPSLNSEIFLYNMEDAKLKAILDGNYITA
                     FRTAAVAALAIDTFAKKDFNTIAIMGLGVTASAIMNMLSYTLKDKNINIKLLKYKDQA
                     ESFVKKYEKNEQFSFEICDTHEELIVDSDVVISTVTYTDEYLSEFKWFKKGALLLPVH
                     VMGFGNVDYLFDKVYLDDYNHLKHLENIDRYKYSCEFYDVLSKQAKGRENDDERIISY
                     NIGLSIHDILFANKIYELCETLSCEEIELKEPKEKYWI"
     gene            45617..46024
                     /locus_tag="KR257_000571"
     CDS             45617..46024
                     /locus_tag="KR257_000571"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895330.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="WxcM-like domain-containing protein"
                     /protein_id="HBH0029298.1"
                     /translation="MDKYNLIRFVSIGNEYIGNLVALESNKAIPFDIKRVYYIYDVPN
                     NVKRGFHAHKNLEQVLVCLNGSVKIKCYDGVKETIFNLHKNDVGLYIGTGVWHEMFDF
                     DEKTVLISIASEHYNEEDYIRDYKEFLKYLNNV"
     gene            46111..47202
                     /locus_tag="KR257_000572"
     CDS             46111..47202
                     /locus_tag="KR257_000572"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009901743.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DegT/DnrJ/EryC1/StrS family aminotransferase"
                     /protein_id="HBH0029299.1"
                     /translation="MLVKFNNLLKQFQTHKEEYEQKIKDVMESGYYILGNEVKHFEEE
                     FANYVGSKYCVGLASGLDALIIAFRALGISKGDEVIVQSNTYIASVMGISINGATPVF
                     VEPNEYYNIDSSKIEEKINSKTKAILVVHLYGQASNMKDIQELCDKYNLYLIEDCAQS
                     HGAKYDGKMTGTFGDIGCFSFYPSKNLGAFGDAGAIVTSNEEIADKVKILRNYGSEKR
                     YYNKFVGYNSRLDEIQAGLLRVKLKYLNEIEIEKSKIVDRYLNEINNPKVILPKIENN
                     CTHVWHLFVLQVEKRDTFMEYLKKSGIESIIHYPIPPHLSEAYAYLGYKKGSFNIAEN
                     YSDKVVSIPLFIGMEDEEVSYIIKIINEY"
     regulatory      47511..47601
                     /regulatory_class="riboswitch"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF01051"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="cyclic di-GMP riboswitch class I; Derived by
                     automated computational analysis using gene prediction
                     method: cmsearch."
                     /bound_moiety="cyclic di-GMP"
                     /db_xref="RFAM:RF01051"
     gene            48012..48329
                     /gene="flgB"
                     /locus_tag="KR257_000573"
     CDS             48012..48329
                     /gene="flgB"
                     /locus_tag="KR257_000573"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860696.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flagellar basal body rod protein FlgB"
                     /protein_id="HBH0029300.1"
                     /translation="MNTYDIIKMGLDATNLRSQTIANNIANINTEGYKRHYITFEETL
                     NDAMPKIEEKTDNSKGLRVDGNNVDIEEEKVNQAMATLQYNALISFANGKIAMTKSII
                     SGR"
     gene            48337..48741
                     /gene="flgC"
                     /locus_tag="KR257_000574"
     CDS             48337..48741
                     /gene="flgC"
                     /locus_tag="KR257_000574"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425244.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flagellar basal body rod protein FlgC"
                     /protein_id="HBH0029301.1"
                     /translation="MSVFSGMRISASGLTAESLKMDIISSNVANINATRGPNGEAYRR
                     KVVSFEENYDNKLGMLGVKVTSVEDDKSPLKEVYDPSHPDAKPNGYVEYPNVNILVEM
                     TDLITASRAYDSNVDTLNAQKSMISKALEIGK"
     gene            48751..49068
                     /gene="fliE"
                     /locus_tag="KR257_000575"
     CDS             48751..49068
                     /gene="fliE"
                     /locus_tag="KR257_000575"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425242.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flagellar hook-basal body complex protein FliE"
                     /protein_id="HBH0029302.1"
                     /translation="MPITQINNLMQGAKLDNLIGEAKPLTLNNKEEKKNFEDVIIDTI
                     DKVNFQQVTADDMKEKFIKGEDVSMHEVMLIGQEAQLSMQYLIEVRNKIHDAYQEMNK
                     VQI"
     gene            49093..50643
                     /gene="fliF"
                     /locus_tag="KR257_000576"
     CDS             49093..50643
                     /gene="fliF"
                     /locus_tag="KR257_000576"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425240.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flagellar M-ring protein FliF"
                     /protein_id="HBH0029303.1"
                     /translation="MITSFKNKIKEQVAKSRTKISSLKKGTKIALGIGVIAICLALVF
                     TAISASKNKYAVLFSELDAQDAADISAELESKKIDTKVKGSTIYVPRTEVDKLRLELA
                     PSLTGGSKGFALMDDSSSIGLTDEEFQIKKQRMIQGEIEKTIKSFPQVEDTRVHITFG
                     ESSVFEKEAVPGSAAVYLMLKPGTTLEKNQIKSVMALISGSVTNIPEKNVQVIDNKMN
                     LLSEGILEDENVDENNQPINSGISVDKNKASEQALNKQLEKSILEMLEPIFGKGKVKA
                     TVNADLSFDTAEKTEIKIDPDKVAIKETRSKNSSKSAANNVQGVDANMNNQGNNNGTN
                     TEDSLDESFEYETGKIETHTIVAPGELNRLTASVAIDGKIAKGVQADVEDIVNNAIGM
                     DGARGDTLSVVSMVFDPEGKKEAKQELEEIKKEGFKKNIIKAVIGVVAVIAVGAIGYL
                     IYKKRSEREDMDYEDEDYISKSDSVDRKDNPLLGDDPELTLEEAVKMYAEEKPDQVTE
                     IIKTWLNE"
     gene            50656..51726
                     /gene="fliG"
                     /locus_tag="KR257_000577"
     CDS             50656..51726
                     /gene="fliG"
                     /locus_tag="KR257_000577"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009901747.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flagellar motor switch protein FliG"
                     /protein_id="HBH0029304.1"
                     /translation="MSTEITNVNAFDLSDINESDKNEKVEGEGLKKAAVLLMTLGPNV
                     SSDIIKSLPDKQVQKIGLEIANISSIASKERREILKEFVEINRAKDYVIEGGLEYARE
                     LLSNALGNVKANKLLEGISINTSTKPFKHIIKLDVKKILEILRNESAQTIAVLLAHME
                     PENGAEVLSYLDFDLQNEVAMRISSMGSISPEVIKVIESSLEDKLHSISGDDFNDYGG
                     VSTLVQILINSDRKTEKNILGTIEEQNPDLAAQIKSHIFVFEDIVKLDDISIQKVLKE
                     VTMKDLVYALKGVDDEISDAIYRNQSSRAADALKEEMEMVGVIKVTQVEASQQKIANI
                     VRKLEREGAITIVRNFGGDFVE"
     gene            51719..52450
                     /locus_tag="KR257_000578"
     CDS             51719..52450
                     /locus_tag="KR257_000578"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860699.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flagellar assembly protein FliH"
                     /protein_id="HBH0029305.1"
                     /translation="MNNKIIKSKKALYKGVLDLTIIDKVRVGESNVNKENDCRFRDEV
                     IKEAIESAEIKKNEILEEAKINAQNIEKQAYEKGYSQGQKNGYEDGYKESYDEYTQKA
                     KDEADFIKNQANLILLQANEKMTEYIKEKNKEIVRLAINMASSVLKKHFEDEESMSDL
                     LKQIIQDYEGSSSFIVRCNSFYKDNIEKEFELFKEETSLKSSVFVIADDSIDKGNAII
                     QKENGRIIVGIDCAMEKLKEELLGE"
     gene            52454..53773
                     /gene="fliI"
                     /locus_tag="KR257_000579"
     CDS             52454..53773
                     /gene="fliI"
                     /locus_tag="KR257_000579"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009901749.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flagellar protein export ATPase FliI"
                     /protein_id="HBH0029306.1"
                     /translation="MYKTDISIDFDKINKKIENLELTISEGRVKKIIGLTVEVEGIKA
                     FVGELCVIYNQVNKPVNCEVVGFKDKEVILMALGELTLIAPGCKVISKGIPLSVMCSD
                     NLLGKVLDGLGNPIDNSDAVLGDRYNLNNEPPDPMKRKKIRNIMETGVRAIDAFTTCG
                     EGQRIGIFAGSGVGKSTTLGMIARNAKADVNVIALIGERGREVLDFIDKDLGEEGMKK
                     SVVVCATSDKAPLVRLKGALTATAIAEYFRDQGKKVILMMDSVTRFAMAQREVGVAIG
                     EPPAQKGYTPSVFAMLPKLMERTGTSDKGSITAFYTVLVDGDDFNEPIADTTRGILDG
                     HIVLSRDLANKNHYPSIDVLNSLSRLMNEIASKEDIKIASFARDMLAEYREAEDLINI
                     GAYASGTNKKIDEAIYYHEHIINFLKQGINEKSSFNETISSLRRVFE"
     gene            53804..54250
                     /gene="fliJ"
                     /locus_tag="KR257_000580"
     CDS             53804..54250
                     /gene="fliJ"
                     /locus_tag="KR257_000580"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012815984.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flagellar export protein FliJ"
                     /protein_id="HBH0029307.1"
                     /translation="MELDKNFKFRLQKVLDLKVKDEEEIKMEFAKIQQKKIDIETNLE
                     NLESNYSKYSISKNNDSIQNQKITINYLLALNNSIMDLSEELDKSTNELEKARKQLIS
                     KQIERKSLEKLKEKKYGQYYKEENLKEQNTNDEFASMSYLRNRQVL"
     gene            54279..55484
                     /locus_tag="KR257_000581"
     CDS             54279..55484
                     /locus_tag="KR257_000581"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435997.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flagellar hook-length control protein FliK"
                     /protein_id="HBH0029308.1"
                     /translation="MKIQADSYNIIKDIGDRKSSSKNKNIKNNKFEDNLYKATDHKKV
                     KDRREVSKQNISSDKPENSDNECHLDEDKSNHLEDENTYEKDCSKNNEALQQLLNLLK
                     DNYKKDKDINTILNNIEKLSISDELKQELKLNKNILNKIANQNSELNKANINNSNDIE
                     NLDIVKLRELLEDNANKDIEVITKTTENDTKNIDLYSFDSNRMDNLNSNKQKDDSSDI
                     LEKLAGVNGNKSGNFGQVINKNVDMNKIKNDNVNLKQIESNVMDDSIKAIKHMKTNDI
                     QELTIKLRPKELGDMNIQLLKDGESMRAVVTVFNKDVFDSINKNIADLKQHLELTNVN
                     IKDVSVQMHSDNTNTSDTFDKAFEQQNRQNNQENMSKKNTNDKHNNVVIEDDIKENTI
                     DDDRVDLLA"
     gene            55502..56110
                     /locus_tag="KR257_000582"
     CDS             55502..56110
                     /locus_tag="KR257_000582"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860703.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flagellar biosynthesis protein FlgD"
                     /protein_id="HBH0029309.1"
                     /translation="MYGIATALAGTQGNYRSNNLSQLERNINDIANKQVRSKGNQTVT
                     DNGTPIIGQGDDADKDLFMKILVAQMGNQDPMNPQDPTEYVSQLAQFATLEKMSAMNE
                     KLDVLLALSNSTLINSALSMATSLIGKEVEVSGEEKEDENIVGVVKSTYIKDGEVHLE
                     LEVDGSDKTVGVKYEKLLKIGEVDENSGEENDSSEHESPEEA"
     gene            56137..57120
                     /locus_tag="KR257_000583"
     CDS             56137..57120
                     /locus_tag="KR257_000583"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435994.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flagellar hook-basal body complex protein"
                     /protein_id="HBH0029310.1"
                     /translation="MIKAMYSGVSGMKANQTKLDVIGNNVANAGTTSFKKSSARITDS
                     FYQTVLYASAPTAALGGTNLGQVGVGSKISSINKDMVQGNVQPTNRPSDLMIDGDGYL
                     PVVRQGTVMYTRDGSFNLDTGFKAADGALKNIKGGRLVNGDGYMLQGMIYDGEYKADT
                     GEFVKKGDAKGKEPIVIPLQSISPKDGTVQNVLEYNISKDGTVEFLLSDGQRTQFVYD
                     IPDGAKVGDTPAGIDKLKGTIQKVQTYAFQNPAGLDAEGGNLFKPSANSGDPQIAGAT
                     GTIIQGAIEASNVDIAEEFTEMIIASRSFQANSKIISTSDEILQEIINLKR"
     gene            57133..57336
                     /locus_tag="KR257_000584"
     CDS             57133..57336
                     /locus_tag="KR257_000584"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425222.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flagellar FlbD family protein"
                     /protein_id="HBH0029311.1"
                     /translation="MIRVTDLNGRKYILNSDLIVRIDSVPESRILLTTGEKNLVKESV
                     DEIVDKVIKYKRKINVGYIRSEK"
     gene            57336..58154
                     /locus_tag="KR257_000585"
     CDS             57336..58154
                     /locus_tag="KR257_000585"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009901756.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MotA/TolQ/ExbB proton channel family protein"
                     /protein_id="HBH0029312.1"
                     /translation="MKKTDSLTFIGLIVSTVLVLVGAAKGSSSGLKNFFDVSSILITV
                     LGSFGALMITFTIDDIKLIKNALQYSFKTMSVSKLDLLEQFKTLSKKARKEGLLSIES
                     DVMGIEDPFMKKGLELCIDGLEINEIRSILELEIDSVEDTNNRYSKLFKTWGTFAPAF
                     GMLGTLIGLIQMLADLTSPDLIASGMGKALITTFYGSLLANIALNPIAYNIDEKTEKE
                     IYVKEMMLEGIISIQSGESSIVVEERLATYLSNNEKLEIMKSNKNTERAMSNGA"
     gene            58144..58839
                     /locus_tag="KR257_000586"
     CDS             58144..58839
                     /locus_tag="KR257_000586"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425218.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="OmpA family protein"
                     /protein_id="HBH0029313.1"
                     /translation="MARKKNKKKDEINPDAWLATYADTITLILTFFVLLYATSVVDME
                     KFKNIADALKGQFSGTSIFSTGSSTSEKSPIDSVLVDKNDKSNLEQDLKDKVNNSNLQ
                     NSVTVKDDSRGILLELDDSILFDSGISELKVDSKATLNKVYDMIKMMKNKIVIEGHTD
                     NVPVKSSTHESNWDLSSSRAVSVVRYFVEEKGMDPRLFSATGCGEYQPLVSNETAKGR
                     AENRRVNILITID"
     gene            58851..59294
                     /locus_tag="KR257_000587"
     CDS             58851..59294
                     /locus_tag="KR257_000587"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435981.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flagellar basal body-associated FliL family
                     protein"
                     /protein_id="HBH0029314.1"
                     /translation="MFKNKKIIIIILILIIFSAGAGFFILGEGGNKQVDKIADLFIPT
                     GKGKDEVKTENLDLEEMVLKLADEGVRYLKVSITVSYDSSYKDIEKNTPLIRDNIINC
                     FMAKRADDFTADNLKNIKEEIKNTLNIQLGENVIQNIYFTNIVVQ"
     gene            59309..59683
                     /locus_tag="KR257_000588"
     CDS             59309..59683
                     /locus_tag="KR257_000588"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009901759.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flagellar biosynthesis protein FliZ"
                     /protein_id="HBH0029315.1"
                     /translation="MILYLLKILICIPIILILIVLSLKISQGTLLKKYNDKYVKILDI
                     VNISKNNSIIILKIGEEGCIMASSSSSMSKIKDLTKEEILKIENDIKERNFKIQDFKM
                     ERIKKKYDFSRYIGKFTKKEDK"
     gene            59684..60349
                     /gene="fliP"
                     /locus_tag="KR257_000589"
     CDS             59684..60349
                     /gene="fliP"
                     /locus_tag="KR257_000589"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425215.1"
                     /note="The bacterial flagellar biogenesis protein FliP
                     forms a type III secretion system (T3SS)-type pore
                     required for flagellar assembly; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flagellar type III secretion system pore protein
                     FliP"
                     /protein_id="HBH0029316.1"
                     /translation="MELLSKLPLADVPYTSSMQLFLFLTALMFLPFVMFMMTSFVRIV
                     ISLSFLKSALGAQQAIPSQILVGLAIVLTIFIMRPVLNEINEKALQPYMKEEVTMEEA
                     MKEAEGPIKEFLLTQTRQTDLDLFVEQAGLKEKKLTRENIPLSVVVPAFAISELKTAF
                     QIGFLIYIPFLIIDLVVASVLMSMGMFMLPPVMISLPFKLLLFVMVDGWNLIVKTLIL
                     GFG"
     gene            60362..60631
                     /gene="fliQ"
                     /locus_tag="KR257_000590"
     CDS             60362..60631
                     /gene="fliQ"
                     /locus_tag="KR257_000590"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425214.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flagellar biosynthesis protein FliQ"
                     /protein_id="HBH0029317.1"
                     /translation="MSEFMIMSVLKNGMFTGAMIAAPVLIVSLVVGLLISVFQATTQI
                     QEQTLTFVPKLIAILLVVAIGGSWMLHTLISFTSEIFNMISLITK"
     gene            60643..62457
                     /locus_tag="KR257_000591"
     CDS             60643..62457
                     /locus_tag="KR257_000591"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860706.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="fused FliR family export protein/FlhB family
                     type III secretion system protein"
                     /protein_id="HBH0029318.1"
                     /translation="MIFVFIRIVAFFGTLRILFPAGTPALFKSLFAIIISILISSTMQ
                     IEYATNIDNIVLFTLYGVNETITGIMLGYITNLCFYSIRMAGSMMDQQMGLSMINMFD
                     PNSMTQTTLIDNLMNWTALMIFFSMDGHHVLIRGIRYSFELIPIGKPFVDNNIDYIIN
                     IFVQCFLTGFKIAIPIVLCLLMADFILGLISRSVPQLNVMIVGMPLKILVGIALFIIS
                     IPLIVNQISHLLSQIPKMYEGTFALAPMFFMGSADKTEEATPKKKGEQRKKGNIAKSR
                     ELPVAMTLLAFTLLVPTLFSYVVDTLKSSLNYFLSLDFYMNINYSNLEKLVIAGLMDF
                     FKIFLPIAIPFLVLGIIANLFQVGILFTGETLKPNLSKLNPISGFKNMFSMRSLSTLI
                     KDTAIISILAYIGYTFFQDNYLDILKLGNIYLPTLMYTVKDLVYSILSKICVAMIAIA
                     VADYVYQRYSHKKQLRMTKQEVKDEYKNSEGDPEVKAKIKQKQRQISSQRTMQAVPSA
                     TVIVTNPTHLSIAVRYEKGKDQAPVVVAKGADYLAFKIREIAKGNNIPIIENKPIARL
                     LYKQVEIDQEIPEDMYQAFAEILVAVYKIKNRYKVPKR"
     gene            62466..64541
                     /gene="flhA"
                     /locus_tag="KR257_000592"
     CDS             62466..64541
                     /gene="flhA"
                     /locus_tag="KR257_000592"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895344.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flagellar biosynthesis protein FlhA"
                     /protein_id="HBH0029319.1"
                     /translation="MNKFNLKENMDVIVAFGVVGIVLMMIVPLPTFILDILLAINISL
                     SVLILLMTLFTTNVLDLSIFPTVLLVTTLFRLGLNLSSTRLILTQGYAGEVIEAFGSF
                     VVGGNYVVGIIIFLIILIVQFVVITNGSGRVSEVTARFTLDAMPGKQMSIDADLNAGV
                     IDDKTARKRRKELQQEADFYGSMDGANKFVKGDAIAGLIVTAINIIGGIVIGAVMLNM
                     TLMGAAQTYVRLTIGDGLVSQIPALLISTSAGIIVTRASTDENFGDLVGKQLTAIPKA
                     VMMTGCVLIVLGMMPGLPKPAFFSLGIGAIAAGYFLGREKKDTLEDLEFEKPDMVNPD
                     KNEVEDVTNLINVESIEVEIGYGLISLADESAGGDLLQRIASIRRQCAIDMGIVVQPI
                     RIRDNLQLNPNQYNIKIKGNVVGGYEIMPNMVLCMDPMNQGFSIFGIKTIEPTFGIEA
                     LWIESDKVEDAELKGYTVVDSSTILITHLLDIIKSNAHELLGRQEVKTIIDAARENYS
                     AVVDELIPDLMTLGEIQKVLKNLLREKVNIKDRVTILETLADQSRNTKDIELLTEYVR
                     IALARSICNNLVDDDKTIVVATLSPETEELVSNNLQRSVNGTYPAVDPENTNKIFESI
                     QEVMSNVYFNHNIPVIVVSPKIRAPFRKLVEIVYPNLTVLSLNEIPNDIKIKAEGVVS
                     IYDDEKVYS"
     gene            64516..65532
                     /gene="flhF"
                     /locus_tag="KR257_000593"
     CDS             64516..65532
                     /gene="flhF"
                     /locus_tag="KR257_000593"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425210.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flagellar biosynthesis protein FlhF"
                     /protein_id="HBH0029320.1"
                     /translation="MMTKKYTANTIQDAMNLAKMELGDNITLIDKKEVRKSGIQGIFS
                     KKDIELTIGWEKRENVEQKDLKREIEQLKSIINNMGFDNKNDNDIDKICKNLLSLELN
                     EEIVESIRIDLQEMKFNGIDTSKNLVEILKKKIKIENQVINGKIALVGPPGVGKTTTI
                     AKLAAKLVFEENKKVGVITIDTYRIGAVEQLKIYTDIMNIPFKGVISPDEMELALDEM
                     KDCDVVLIDTTGRGYKNSMQILEIKNLIDKAETDNIHLVLNCTTRESDTKAIIDSYRN
                     VNFKSLIITKLDETITYGSIFNIMNYAQKPISYITTGQNVPDDIIKPNEDKIIRLLLG
                     VESI"
     gene            65529..66407
                     /locus_tag="KR257_000594"
     CDS             65529..66407
                     /locus_tag="KR257_000594"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435971.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MinD/ParA family protein"
                     /protein_id="HBH0029321.1"
                     /translation="MIDQAQILRKIAMEKRGLDEFIVENENVPKIITIASGKGGVGKS
                     NLATNLSICLTKLNKKVLILDADIGMSNIDIIMGVNVKGTIIDVINGEKNIEDIISQT
                     KYGVNIISGGSALNHIEDFTEAQRNKFIHSIEQIHDVDFIIIDTGAGMSKSLLSFIYC
                     STEFFLITTPEPTSLTDAYSLLKAISNFGIKRSANIIINRVIDLEEAKSTYKRIKMVV
                     DKFLNLNLELYGYIIDDKKVSLCVKKQIPFILEYPTSIASKCIIAIAKRMVSQSREDI
                     VDNKSFLRKMFSIFKS"
     gene            66421..67122
                     /locus_tag="KR257_000595"
     CDS             66421..67122
                     /locus_tag="KR257_000595"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009901765.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="FliA/WhiG family RNA polymerase sigma factor"
                     /protein_id="HBH0029322.1"
                     /translation="MNREELIKENMPLVKSIARKFFIPGKGFEYQDLVNSGVIGLIDA
                     INKFDAEKGAKFSSYSYIKIKSAILDEIRNQSPISKHNLTKVNKYNRVVEKLQSKLLR
                     EPTSYEIAKELKVSEKELHDIESNIDMLNIVSLNYVIFEDTNETVQDVISDREEEAPE
                     NIIEEEEKLEILSKAISNLNEREKLILSLYYYEDLNLKEIGKVLGVSESRVSQLHRKS
                     IRNLRNKIKELKYSI"
     gene            67138..67560
                     /locus_tag="KR257_000596"
     CDS             67138..67560
                     /locus_tag="KR257_000596"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729253.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flagellar protein"
                     /protein_id="HBH0029323.1"
                     /translation="MIQIILIVVSILIIVTIVINLHKESKNKDNRYFDKIFEQEYEAN
                     DRLIIAEKRRFFLDKVLAEKRINSHIKVYENYNLIKANEERKENIFIESKKEVRQENE
                     LSLKVKHLISSGYDDVEICKMLDIGKGELLLIRSCYKI"
     gene            67545..67730
                     /locus_tag="KR257_000597"
     CDS             67545..67730
                     /locus_tag="KR257_000597"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425206.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flagellar protein"
                     /protein_id="HBH0029324.1"
                     /translation="MLQNIRILLCDKKVFLGIGIGILISTLCIMLFSNNDMSKAEIEK
                     KARALGMKYTSEMKVLE"
     gene            67771..68544
                     /gene="flgG"
                     /locus_tag="KR257_000598"
     CDS             67771..68544
                     /gene="flgG"
                     /locus_tag="KR257_000598"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425203.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flagellar basal body rod protein FlgG"
                     /protein_id="HBH0029325.1"
                     /translation="MIRGLYTAVSAMITNQQKQNVVVNNLANMDTNGYKSKQLLTKSF
                     DELKLEGYNNYANGTKQKQIIGDISPGISMDETITNFNQGPIKTTDNKMDVAIQGKGF
                     FLVSDAAGNQFYTRNGNFRTDNQGDLITSEGYYVLGTNTATGAVGHINVGNQKFEVAK
                     DNTISLDGNAMYKFNIVDFNNYNNLKKEGDNLYSGGGAMKVNNALTIQSAIESSNVDM
                     VSEINNMMTISREYEANQKIIQAMDSKLAKIASEIGSVR"
     gene            68565..69326
                     /gene="flgG"
                     /locus_tag="KR257_000599"
     CDS             68565..69326
                     /gene="flgG"
                     /locus_tag="KR257_000599"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895351.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flagellar basal body rod protein FlgG"
                     /protein_id="HBH0029326.1"
                     /translation="MYTMFYTSKTALSANQSKLDIISNNIANSDSTGYKKINMEYSDL
                     VDEVLNRPSYPTNGNDISTGTGAKATAPMRNYEQGALAPTDSKSNLAIDGEGFFRVIR
                     KDGTYAYTRNGGFNVDALGKIVDDNGNILDVQFDAGYNYNNTNIDSTNLTVSRNGELF
                     VDNKKIGKINLYQPIGTQNFISEGDSLFVATDAAQIKQVEKVDIVQGYRERSNVSLQE
                     EFVDLIATQRAFQMNSKGIKTADEMWQIANNLRAK"
     gene            69349..70230
                     /locus_tag="KR257_000600"
     CDS             69349..70230
                     /locus_tag="KR257_000600"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435965.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="FliM/FliN family flagellar motor switch protein"
                     /protein_id="HBH0029327.1"
                     /translation="MNDMKEYDFGKPQSYSRENLTCLNFLLAEFCKKYKNYIIYELKC
                     NSSMVVDSIDQVNYQTFLDRVTSSCVVVQNAMEPVMKNFSFRIDRSVADMWIDITSGG
                     TGVVKDNDRELTELDKKVLLHLMDDLVRNMHLFEGFENIQVLDTHTHINLPQLCSPTA
                     PVCVVDLKVLNDNEYIGSVSLCFPYNGLEALLESISVIEFFDNDVGDDSEEFTQKIYN
                     SVSNIELSVIAEIGKVSINVEDLLKLEVGDVIVTNKKINDYIDIFVENSKSYTATPGF
                     ISSKKGVKINDAVGKEV"
     gene            70233..70607
                     /locus_tag="KR257_000601"
     CDS             70233..70607
                     /locus_tag="KR257_000601"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888109.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="FliM/FliN family flagellar motor switch protein"
                     /protein_id="HBH0029328.1"
                     /translation="MDNSNLISDEEAKMLLNDKVESEVDGDDELALDVSEVNRNNIQR
                     ILDLKLELSVVIGRTKMTLRDILNLHKGSLIELDTLADQDVEILIDNKVLAYGKVVVV
                     DLNFGVKITSIVSEEDMVKSLV"
     gene            70639..72042
                     /locus_tag="KR257_000602"
     CDS             70639..72042
                     /locus_tag="KR257_000602"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009901769.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tetratricopeptide repeat protein"
                     /protein_id="HBH0029329.1"
                     /translation="MVLILNLNDIKKDILKLNKKDSCSLYNESINNINNNCISTGLKF
                     LKQARDLNPDDVDILNLTGLVNLLKCNFDDAVESFYKSSLCEKTALCEKYINMLTSEE
                     FLIFFEKYNQLIRLINKGMYKEAIQGFKLITDQYCDLIEPYELLALLYDKEEEYIKFD
                     ECLEVLKIIDKENYLLNQENNTLYMYNSANIQTKSNIKVDDYKNEFLHKSSSNHKIND
                     YNDVTKEKSSSKNQKSSDSNKKKSIKKNKYLYIAIILGILLVGQSIYSSYKMNNLTDK
                     ISKNNETKNEESIDSNLTKKENNIEENEDMSKASNINKSNKNINKEDDVKSKKNTVEN
                     EDDKDSDLFTEDELMSKANTLKSEKKTKSSIQLYKKVADIGENKGNTSEATYQVAILS
                     EKLKDYKTAEEYYKMYVENYSEKDAYFDESYYNLGMMYYNNGDLKNSKLTLKKLVNKV
                     PNSMYNNSKVKEILKEE"
     gene            72158..74095
                     /gene="htpG"
                     /locus_tag="KR257_000603"
     CDS             72158..74095
                     /gene="htpG"
                     /locus_tag="KR257_000603"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435963.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="molecular chaperone HtpG"
                     /protein_id="HBH0029330.1"
                     /translation="MEFEKGSISIHTENIFPIIKKWLYSDKDIFIRELISNGCDAVSK
                     HKRLVSLGEISENKSSDYKITVSVNKGEGTLKFIDNGIGMTEEEIKKYINQVAFSGAE
                     DFFNKYKDKMEESNDIIGHFGLGFYSAFMVSKKVQIDTLSYTEGATPVRWISEGGTEY
                     EISESDARNDRGTTITLFIDDDSKEFLDEFTVRGIINKYCSFLPVEIYLEDVERLERE
                     AKEAEEKAKKQKEDGKEEIVDAKVIEPLNDTNPLWLKSPKDCTDEEYKEFYRKVFNVF
                     DEPLFWIHLNVDYPFNLKGILYFPKLKNEFELTEGKVKLYNNQVFVADNIKEVIPEFL
                     LLLKGVIDCPDLPLNVSRSFLQNDRDVSKISKHIIKKVADKLKSLCKNEREEYNKFWD
                     DIQIFIKYGCLKDESFYEKVKECILFKTIDDEYITLQDYLEKCKDKHENKVFYVSDKE
                     QQSQYIKLFKEYDLSAVVLNSSIDTHFISFMEYKENGVKFNRIDADLSDVLKDKNENK
                     DSEENKEEIAKIEGLFKEAVGERVKNYSVEGLKNEDTPAMVLVSEQSIRMAEMQSRFA
                     GMDLGMNFEEEKTLVINENSPIIKKLVSLKDDEEKKDKITLICNQIADLALLSNKELK
                     PDELDSFVQRSNKLMSLLIEL"
     gene            74482..75612
                     /locus_tag="KR257_000604"
     CDS             74482..75612
                     /locus_tag="KR257_000604"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435962.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="iron-containing alcohol dehydrogenase"
                     /protein_id="HBH0029331.1"
                     /translation="MNFNYNLPVNILFGRGRINDVGKEVSKYGKKVLIVTGKNSTKKT
                     GLLDKTIDLLKDSKIEYEVFDRVEQNPLITTIYSGVEIIKSTGCDCVLGLGGGSIMDA
                     AKSIAFSYKNPGDLNDYIFGIRQGEEALPIILVPTTSGTGSEGNCFAVLTNSETKDKK
                     SIKKNSMYAKASIIDPELMVTMPKHIIASVGFDALAHNMEAYLSNGRNPLADVQAIYG
                     IELISENLIKVYNDVNDLEAWEKITLASTIGGMTIGTAGTALPHGMEHPVSGLRDVMH
                     GKGLAALTPTIIESSWDSDIERFGNISKVLGGTCAEDCSDAIRNFLKKIDLDIKLSDL
                     GIEKSDIDWLTDNCMKISVANIKRHPKYFNKEQIKEMYHKSL"
     gene            75839..76861
                     /gene="splB"
                     /locus_tag="KR257_000605"
     CDS             75839..76861
                     /gene="splB"
                     /locus_tag="KR257_000605"
                     /EC_number="4.1.99.14"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421014.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="spore photoproduct lyase"
                     /protein_id="HBH0029332.1"
                     /translation="MFNPKRIIFEKGTLDTDVGKKIYNKFRDNKDVEIINISSNRIKE
                     HIPGENLYEQYRSGKQTMVVGIRKSLKFQTCKPSANYQLPLVSGCMGRCEYCYLNTQL
                     GDKPFIRVFVNVDEILEQTKKYIEDRKPQVTIFEGAATSDPVPVEPYTNSLKKTIEFF
                     GREEKGRFRFVTKYSDVDSLLDAEHNNHTEIRFSINTPRIINEHEHYTASANKRIESA
                     VKLARAGYQIGFIIAPVFLYEGWKEEYKNLIISIKEALPKDFDKKIIFEVISHRYTTK
                     AKNRILEIYPDTLLPMENEDRKFKYGQFGYGKYVYDKEQLDDMKEFFLKEINGVFKNS
                     LIKYII"
     gene            77043..77954
                     /locus_tag="KR257_000606"
     CDS             77043..77954
                     /locus_tag="KR257_000606"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435959.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AraC family transcriptional regulator"
                     /protein_id="HBH0029333.1"
                     /translation="MHAWESIQITLDLIEANLSEEISINELANKANLSPFYYQRLFKR
                     LVNKTVMEYIKLRRLARASEYLAEHKNRILDVALNFGFASHETFTRSFKKAYGLTPEK
                     YRANPVKLNHFIKPELILNYAMVDEGVPLIADDIVIEVNRKTLSNPRTFVGIEIEVPI
                     CQLVGGETTGIAIVEELWMKLGSQRHNIPNQIPGGNEFAALYMGNAKEGNCMYMAGVE
                     VESGTSVEGYSTFELPAKEYLVCGFEAENFNELVNSAVFKADKFMERWMKKHNLTTTD
                     FAIEMYYPTTPEAAYLEHWIVPVPIEQ"
     gene            77969..78385
                     /locus_tag="KR257_000607"
     CDS             77969..78385
                     /locus_tag="KR257_000607"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888119.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3788 domain-containing protein"
                     /protein_id="HBH0029334.1"
                     /translation="MNWQDAFFQDTKPTFEQINEFINNPLWDKLNKTLVSTYNVEPKL
                     EYSKCSMQRGWNVKYKKRGKSLCTLYPQEGYFKALVIVSESNRVEVDLFINTCCDYIK
                     KIYNEVNFFNGSKWLMIQVDSLLVLNDMLELIKFRA"
     gene            complement(78485..78877)
                     /locus_tag="KR257_000608"
     CDS             complement(78485..78877)
                     /locus_tag="KR257_000608"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435954.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HBH0029335.1"
                     /translation="MSINTEKNITKNVEELTCPIRYALDIVGGKWKLPIICMLAVENP
                     IRYSSIKRKLDGITNTMLAQSLKDLESTGIVHRKQYNEIPPKVEYTLTSKGKSIVPIL
                     QQFANWGATNMQEKNTCGLSCKECRKIK"
     gene            79018..79413
                     /locus_tag="KR257_000609"
     CDS             79018..79413
                     /locus_tag="KR257_000609"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435952.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pyridoxamine 5'-phosphate oxidase family
                     protein"
                     /protein_id="HBH0029336.1"
                     /translation="MKALEFLNKARVYYLATVDENNQAHVRPLGFVMEYNGKLTFCTS
                     NQKDMFKQLIFNPKVELCCIDQNLNTLRILGEAVFVTSKETQAKALEIMPSLGQMYSV
                     GDGKFEIFSIDKAKVSCCSMSGKKIDVEL"
     gene            79816..80022
                     /locus_tag="KR257_000610"
     CDS             79816..80022
                     /locus_tag="KR257_000610"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435950.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0029337.1"
                     /translation="MSKYSSLWEYFKKNNSQSFKLTFEEIKDIAGIEIDHSFLKYKKE
                     LNEYGYQVGKISLKEKTVIFDKIG"
     gene            complement(80179..80910)
                     /locus_tag="KR257_000611"
     CDS             complement(80179..80910)
                     /locus_tag="KR257_000611"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435948.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0029338.1"
                     /translation="MLSKKNVSLIILVIILSLLTAIFIFNNKNTNNKLKEVTKNNEEI
                     VPKNLEGLSIEQLIEIRDKAIDKNLEGLREFGEDSVKKRKDSILNFEFGLVAFVNKNY
                     SNLTEKEKLIRQINIVNYENSINDIMDPSGSFFELANQNYQVNEFLLKNGKDYKEWSY
                     EGLDFLIDHLEELCKFVDFDVKDVIDIIDPTIKTDLSEEQKKSLNDKLKKISSSDTLS
                     EEVKKEIKNWENNLNNLNMNKNNSN"
BASE COUNT        33011 a         8384 c        14613 g        25259 t
ORIGIN      
        1 tatcaaggta taagaaaaat agtttagttc tgtctataat tttatgttca cttattattt
       61 caatccttgt aattactgtt tttaataccg taaaactaca caatatatct aataaacaat
      121 ctaaaaacta tttaaatgat gtatctacac agattgtaat gaatgttgat tctaaaatca
      181 aatttatttt atccgactta agaataatgg cagattttat taagcaatat gaaggtgata
      241 gtcgatatga gtatttatct aaaagaaaga ctagttataa gtattatgat gttggaataa
      301 tagatttaga aggtaaagct gagtttttaa gtggaaaaaa gtttgactta aagaatactg
      361 tttcctataa aaaaggaatt gaaggtaaag aatactcaga agtaatagag tcaatgggtt
      421 ttgttcttta tagtgtacct atatttaatg ataatcatga agtatctagt attttaatag
      481 gtgtatccaa taaagaaagt atgaatgaga ttcttaatat agataacttt aatggaaaag
      541 gaactattga aattattaat agtaagggaa aacctctttt cataggaaaa aatactgaat
      601 taataaagga ccttagccat aaatataaga gttctggaga tgaaccttgg gcacaaaaga
      661 tgcttgagga ttttaaaaat gataaatcag ggaatattac aataacctca tcaaaaggtg
      721 tacaatgctt attaacttat catccaatta caagaggttt aaatgattgg cattttcttc
      781 tcatagtacc tgaagatgct gtacttggtg aacttaataa attaaactct tttacaataa
      841 caatgacatt tataattaca tgtattattg gaattataac attaatttta tatattataa
      901 gaagaaaata tgtaaatcaa atagaaaata ttgcatattt agatagtata acaaatggta
      961 taaattcaac taagtttagt atgctagtca aacctttaat ttcagaatca cctgatagta
     1021 cttatatgat gatagcaatg aatataaaag attttaagct aataaatgat tgtttcggta
     1081 gtgaaaaggg aaatatgaca ctaaaacatc tttacaatat tttgtataaa aacattgatg
     1141 aaaatgaaga gtttgtgtgc cgtcatgatg cagacctttt ctatttgctt attaagaata
     1201 gaccagtgtt agaagccctg gagttattat ataaaataga agctgacaca aattatttta
     1261 ataaaaatag ggaaaatcca tactttttaa gactatcagt aggtatttac acaattgaaa
     1321 atcataatga agatttaatt acaatacaag accatgcaaa tacagcaaga aaaagcttta
     1381 ataaaactca tcaaagtgat ttttcttttt atagtgatat agaaagaaaa cgattaatat
     1441 ctgaaaagga aatttcaaat ttaatggaaa aagcccttga aaataaagaa ttttttatgt
     1501 gcttacaacc taaaattgat ataaaaagtg gaaaaattag tggagcagag tctcttgtgc
     1561 gttggaaaaa ttcagaaaag ggcataattt atccaagtga ttttattcct cttttcgaaa
     1621 aaagtggatt tatatgtaag ttagatttat atatactaga agaaacatgc aaattgattt
     1681 ctaagtggat aaaagaaggt aaagaagtgt tgagaatttc tgttaatgta tcacgtcaac
     1741 atctgaatga taaattgttt ttagaaaaat ataagcatat atgcaataaa tacaatgtac
     1801 caacatgtct gatagattta gaacttactg aatctatttt cttagaaaat ccagaagcta
     1861 tagatataat agaggatatt cattctaatg gatttaaatg ttctatagac gattttggat
     1921 ttgggtactc atcattaggg atattaaagg attttaaagt tgatataatt aagttagacc
     1981 gttcattctt tgttagcaaa aataatatag accgtggtaa ggtagttatt aagtctatta
     2041 ttgaacttag caaaaggcta ggtatgaaag taactgctga aggaattgaa gaattagaac
     2101 aagttgagtt cctaaaaaat gtgggatgtg attatattca aggttatgtt ttttcaaaac
     2161 cattattaat ttctgacttt gaaaattttg catatgaaaa taataaaatt aaaaatatcc
     2221 attattaaat gtacaagata aaaaatttag gcaagttata taattaaaaa tataacttgc
     2281 cttttttatt tatatattta ataaaaatat atttgcagat tttgtaaaaa taattttcaa
     2341 atgttgtaag ttgtggctaa agctttattg tattattctg aatatagaaa gatagttact
     2401 gtcttagata aaaactgaaa catacataat aatataaaat ttgctatatt aataactcta
     2461 attattttgg aaggagggaa aatatgataa gtgggagaat gttactcatc atgaattttc
     2521 taaaaggaaa aaataagaca agttacaagg atattagcaa acaacttagt atagaagaaa
     2581 gaaaagttag atatgatata aataatttaa atattgtttt gcgttcatta aacaagtcag
     2641 taatacaaaa gatgaacaaa ggtgtgttaa ttattcctga tgacttccaa gtagtatgta
     2701 taaataataa cgaatatgta ttttccttaa ctgagcgagt atctattatg aaaattatat
     2761 caatgtttaa aatagataat ctaaacttag aaaaattaag taaagaattt caggtttcta
     2821 gaagttcaat taaaaatgac cttaatgttt tgtcaagtga attagaaaga aaccaaataa
     2881 ctattactta tgataaatct tttaaaataa gtggagaaga agacattata tataagcaaa
     2941 gattgaacat attaaaatcg tattcttatc tttttggtaa ggaaaaatct gatttaagtg
     3001 tatttgagaa gtatttagtg aatgtaattg aaaaaatatt caaagggatt tatttgattg
     3061 atatatataa ttggtctatg aatttattat tgcaaatggg atggacttta aatgatgaat
     3121 cttttacatg gtatgtgtca aacattttcc tttttacatg gtatatacat tcagatgaaa
     3181 aacatccttt agaatctgct tcattaagtg agccgtgttt tgaaaataag tttgaccaag
     3241 aatttgaaac aattattcaa aaaaagttga ctaaggaaca aatttttctg ttaaagagtt
     3301 ttgtattttt tacaaataaa tatgcaagtt taaacgagga tatggatttg attagtacag
     3361 aaattatagt tcaagaccta atttacaata tgtcagaaat attagagatt agctttaaag
     3421 aagatatgat tctttataaa ggattactca atcatattgc cccattgata gagagaatca
     3481 agcagaatat acagatttat gaggaattac ttcatgtaat accagataaa tatcaatatg
     3541 tacttgaagc tactaaggtt tctattcaaa aaaacagagt tttaagtcaa ataaagaatg
     3601 aaaatgaaac aatacttttg gcaatacatt tcttaggaag tatacataga aatgagagga
     3661 ataactacaa aaatatattg ttagtttgtg gatttggata tggtgtaatt gctatgttaa
     3721 aggatagttt agtaaatgat taccagataa atatagtaga gagtattcca tcatataagt
     3781 tacaagatta taaagactgg gaaagtattg acttcattat aacaacatca aagatagtaa
     3841 tagacttgcc taaaacaatt attgagataa atccattttt acaagaagag gattatttga
     3901 agtttgaaga aaaagggata aaaagaaaga atgtcttaac taattatatg tcaataaaaa
     3961 aaaggttgga ctttttagaa gaagatgccc aaaaaagagt attaagtatt atatgtcaag
     4021 aacttggata cagtgatgag agaatattat ttagacaact taatttaagt gatttaatag
     4081 ggattgatac cataaggata attgatggag atatgaaatg ggaagatgct gtaaaattta
     4141 gttcaaacat acttgctaat tgtgattttg tatcagcaca atatgctgag aatattatag
     4201 atattttaaa aaatgtgggt ttttatgctg taaaagataa cgaatttgct ttactacatg
     4261 gcaatgatag ttcattagtc aaagtaagtt cgataagttt attaatatgt aaagaagcag
     4321 ttagttttgg agataaaaag gttaaaatca tattttgcct agcaagcaga gataaaaaag
     4381 agcaaattcc tgcaataatt aatctaacta aaatggttta taagactaat tttattgcta
     4441 tgttagaaag tgcaaagaca aaagaagaag cagaagtttt aattcataaa tatgagaagg
     4501 aggtcactgt atgaataaat tagttaatgt aaaatgttca tttaaaatac atgttaattc
     4561 aaaagaagaa gccattatat cgttagttga tgtagtgtca aaagaaggat atttaataga
     4621 taaaaatcaa tttttaaaag atgttttaaa gagagaagaa acattgtcga cttatattgg
     4681 acatggtata ggtcttcctc atagtcaaag tgtaggtgtt aaaaactctt gtattacaat
     4741 aggaaagctt gatactccta ttgaatggac agaagaagga gaaaaagtgg atttaatatt
     4801 tttgatatca gtaacaaaag acaatgaaaa taatcttcat ttaaagattt tatcaaaatt
     4861 agcacgttta ttgatgcatg aaagttttag aaatcaaatt agatgttcag atgaacaaac
     4921 tgtttataat cttataaaag aaaaaataga ggaggaagat taaaatgaga attttaaagt
     4981 ttttgcaaaa acatcttatg acagcaacat cttatatgat tccatttgtg gttgcaggag
     5041 gaatattatt tgctttatca gtaactttaa gtggacaagc tgctgttcct gaaacaggct
     5101 ggttggctaa actgaatcaa attggagctg ctggcttggc tttattcatt cctatattag
     5161 gtggatatat agcatttagt atggcagata aaccaggatt agctccaggt atgataggtg
     5221 catatttagc aaaagaagta aatgcaggtt ttataggtgg tatcatagca ggatttatag
     5281 caggatttgt tgttttacaa ttaaagaaaa ttaaattagc tcctacaatg agaactttag
     5341 gttctatatt tatttatcct ttagttggta cattgattac aggtggtata attgtatttt
     5401 taattggaga acctatagct tcttttatga catggatgac aaactggtta aatggaatgt
     5461 ctggtgtttc taaaattcct ttaggtggaa tcttaggagg aatgatagcc tcagatatgg
     5521 gtggccctat aaataaggtt gctgctactt ttgcccaaac tcaagttgac acacttccat
     5581 atttaatggg tggagttggc gttgcaattt gtatacctcc aattggttta ggattagcta
     5641 cattattgtt tccaaaaaaa tttagcaagg aagaaagaga ttcaggtaaa gcttcactat
     5701 taatgggatg tgttggaatt acagaaggag ctattccatt tgcaacatca gatccagtta
     5761 gagtaatacc ttgtattatg gctgggtcga ttgtaggaaa tattatggct tttttattag
     5821 gatgtttaaa tcatgcaccc tggggaggtc tgatagtgtt acctgtagtt gacaataggt
     5881 tggggtatat tgcatcagta ttaactggag cagtagttgt tgcggtatta atgaaattag
     5941 taaaaaaaga cgtgaaagaa gatgaagaaa ttgaagaaga tttagatgaa tcaattgaat
     6001 taatatttga agaattataa atataaatgg aaggaatttg tataaaaaag taaatataaa
     6061 actataaatt taaaggagat aagaatatga aaattgtagc agtaacatct tgtcctagtg
     6121 gagtagcaca tacttacatg tcggctgaat cacttgaatt atcagccaaa aaatttggta
     6181 tagaaataaa ggttgagact caaggaagct ctggaataga taatgaattg tcacttaaag
     6241 atattgatga agcaacttgt gtaatattga ctaatgatgt tgagattaga aatatggaac
     6301 gttttaaagg aaagaaggta gtaagaatga gtgtatctga gataattaag aaatctgatg
     6361 cattaattaa gaaaataaaa gatacttttc aataaaaatt gatttatttt acatataact
     6421 caaagatgtt tttaaagaaa tttttattaa aagcatcttt gaaaatatct taaaaataga
     6481 ataaaaggag atatagtcat gaaaaagtta ccaataaaga ctgtcgtgca aagattacta
     6541 aacttacaag aagaggggaa aagtgcaact cttttaggaa ttggtcctat gtcaccaaac
     6601 ttgttacaag caagttttga actagcaaaa gatgatgatt ttcctttaat gtttatcgca
     6661 agtagaaatc aagtagatgc agatgaacta ggtggcggtt atgtaaatgg ttggaatcag
     6721 gaaactttta caaaagatat taagaaggtt gccgacaaag ttggatttga tggtttatat
     6781 tatttatgta gagaccatgg tgggccatgg caaagagata aagagagaaa tgaccatttg
     6841 cctgttgatg aagcaatgga gttaggaaaa aaatcttatt tagcggacat tgaagcaggt
     6901 tttgacctat tgatgattga ccctacaaaa gacccatttg aaattggaaa agtaattcca
     6961 ctagatgtag tactagaaag aactgtagaa ttaattgagt attgtgaaaa cgagagaaaa
     7021 agacttaatc taccagacat aggttatgag gttggtacag aggaaaccaa tggaggtctg
     7081 acttcaactg agacgtatga aacatttata actagactaa aggttgaact cgataataga
     7141 ggtttgccaa tgccaacatt tatagttggt caaactggta ctttaactag aaagacagaa
     7201 caagtaggaa cttttaattt tagaaatgct tatgatttag ctcaaatggc taagaaatat
     7261 ggagttggtt taaaagagca taatggcgat tacttagatg atgtaacttt attagaacat
     7321 ataccatctc aaattattgc tacaaatgta gctcctcaat atggtactga agaaactagg
     7381 gcatatttaa aattagcaga agttgagtgt aaattagaaa aagagggctt agttgagaaa
     7441 acttctaata tcagacatgt tcttcttgtt aatgcaattg aatgtggacg ttggagaaaa
     7501 tgggtagtag gagaacaaaa aaatctaact actgaagaga tatttaagga tgaagtttta
     7561 tctaatgaaa tactagatat tgcaggacat tatacattta ataatgatga tgttaaaaaa
     7621 gaaatagaag tgctttatga taatttaagt aagaataata ttgatggtca aagatttgtt
     7681 gtagaccata ttaaacgtcc tttgcgtgat tatgcagaat gctataactt aaaaggtgtt
     7741 actacgagga ttttaaataa ataataggac ttatagtggt gagtattgtt atactaggta
     7801 tttatagtta taattatact taccactatt aaatttagga ggactaatat tttgattaat
     7861 ttaatttttg atgtagatga tactttatat aatcaattaa cgccttttta cactgcatat
     7921 aataaagtgt tttcttcaat aaaggatatt tctattgaag atttatatat gagtagtaga
     7981 aagtatagtg atgaggtatt tcatatgact gaaaatggag aaatgccaat caaagaaatg
     8041 catatttata ggataatgaa agcttttgag gagttgggaa attctattac agaaaaagat
     8101 gcacaaagtt ttcaagatga gtatatatat caacaatcac aaattacact aataccagaa
     8161 gttgagagga ttttaaattt ttctaaagaa agaaatatta atctaggaat tataactaat
     8221 ggcccatcaa accatcaaag aatgaagtta aagcagttaa atattgaaaa ctgggttgat
     8281 aaaagtaata tttttatttc tagtgaggtt ggattttcta agccagatac taatattttt
     8341 agagtagctg agaatgttat gaatttagat agagaaaata catattatgt gggtgattct
     8401 tatagaaatg atgtattagg tgctaaaaaa gctggttgga agagtatatg gttgaaccat
     8461 agaggacatg aggtagaaga gttgttttac aaacctgatt ttgtaatttt ggaacataag
     8521 gatttgatat ctttatttat aaaaatatgt agttataaaa atatgtagta aaaaaatgtt
     8581 aataatagaa ttgtataaaa taattaataa taactatata aaattatatg tttagattgt
     8641 gagcaatcta ttttatgtta aaaatagatt atttagaaga aggggaaatc ttaaaaaaat
     8701 ttgaatatcc cctttttatt atttaattaa aatgaaatag ttagaaatat attttattta
     8761 gtttagtcaa taacattttg ggattcttta taactacatg ttaactgttg aataggttta
     8821 tcatatggtt taacccatcc tttattaata cttaattctg taagtgctgt gtgaccttct
     8881 accatttgag ttaatgaagc tgaatatata gctcttaatt caggtgtact acttgtcaat
     8941 gcagaattaa gatacatatt ggcagatgct ttagcagatg aaagcatact taacattatt
     9001 actttatcgt ctatataagt attgttctta attagatttt ctatcatatt tctcatgtta
     9061 tctatacctc ctcagaaatt agtatttcat tttcaactat aaattgttgc atagctttaa
     9121 ttcttccttc tgttgctaat atactagatt ctgattgtct ttttaggtct tcatctgata
     9181 ttaacatatt tattgctctt tgcataagta atccgtcaga ctccattttt ataactgctg
     9241 ctaaagatat tttttcagtt tctgaaagta ttctcattta atcatctcct atattgtaat
     9301 ttatgcttta atagtatgtc tttcttttca aggaaataac cattacactt ttttacagta
     9361 ttttatattc tctttatatc aaaatttagt cgacctaata tattaataat aattttgtag
     9421 gatatttatc attaaatatc tataaaataa attatttgaa tattcataaa gcaaaattta
     9481 tttgtatgta cttcttcaag agtcaatatg agttttttca aaaaattaat ttttatgata
     9541 atcattaagg gctatatttt tcttaaagtt gtgattatca ttattaattt acaataaaat
     9601 tgccgaaaag ccctctcctt taggtgtagg gatgaaaggt aaggtcttaa tataaaaaaa
     9661 gttagaataa tgcttgtaat ctaataccgc tactgatacc ctatatttag gaggtgttag
     9721 tttttatgta taaatctaac aaaaatatag tttatgattg caaatatcat attgtatttt
     9781 gccctaagta tcgtaaacct gttttagttg gcgaagttga aaagatgtta aaagaaatac
     9841 taccatataa agcagatgaa cttggagcag aaataataga aatggaaact gataaagaac
     9901 atgtgcactt attaatatct tgtgaccctc aatatggaat tcataaagta gtaaaaggtt
     9961 taaaaggctt tagttcgaga gtattaagag agaactttcc acatttaaag tctagtatgc
    10021 ctagcatgtg gactaatagc tattttgtag gtactgttgg ttctgtgagt ttagaagtag
    10081 ttaaacaata tatagaaaat caacaagtta ggacaaagaa atgataaaaa ctcatagagt
    10141 gaaattaaac ctaactagaa cacaatttga attagtaagg gaaaagcaaa tggaaagtgc
    10201 taactgttgg aactacatag ttaacttatc taaagaatac tattttgaac ataaacaatg
    10261 gattaaaaag aatgatatac aaaagttaat caaaggtaag tacaatcttc atagtcaaac
    10321 tattcaagct atatcagata aatttgatgc aaatagaaag actatatcag aattaagaaa
    10381 aaaaggtaat actaaagcaa aatatccata caagactaag aaattttata taataccttt
    10441 taaagctagt gctattaata gaaatgctaa aggcaactta aaattatcaa tgtcaaaagg
    10501 caggtattta gaattagatt ttaatgttga gaatataaaa actgctgaaa tagtatggcg
    10561 aaatggatat tatttatact acacttttga caatgaatta aatggagttg tagccaaagg
    10621 cactaatacc gtaggtgtag acttagggga aatacattcg atagctagtg taacaaatga
    10681 aggtgtaggg cttattctat ctaatagaga aggcagaagt attaaacaat ttagaaataa
    10741 gatgtatgct tatatatcta aaagattaag taaatgtaaa aaaggtagta gacaatcaaa
    10801 gaagttatgg agattaaaaa ataagataag aagtaaaaca gataatcagt taatgaattt
    10861 atatcatcaa acaactagaa agtttataga cttttgtgta gagcagaagg tatgtgaaat
    10921 agttcttggg gatataaaag gggttgaaaa agatactaag aaaaagaaaa gattaaacag
    10981 agttaataga cagaaaatat ctcaaatgga gtatggtcga ataaaggact atataaaata
    11041 taaagcaaaa gagcaaggta ttgaagttaa gttagttaaa gaaaactaca cttctcaaac
    11101 ttgcccaaag tgttctaaaa aacacaaacc aactggtaga acttatagtt gtacttgtgg
    11161 ttatgaaact catagagata tagttggtgc ttggaatatt ttaaataaaa agcataaata
    11221 tggtttagta gattttagaa taaatcataa gcaaccaata aatttaaaag tatctaccgt
    11281 ttgagccatg tgtgggcgaa taactttaag gtagtagtgg cgaagacacc gtccgaagta
    11341 gcttggcttt gtaaccacct ctgttgtact gtttaagtat aaataagtgt gttagccacc
    11401 aagaatcccc ttgctttagc tatggggagt gtgtcaataa aatactttaa tgaaaaatag
    11461 ctaactttaa ttgtaggata ttcttaatat atttgaaata aataaaaata ttgaaggata
    11521 taatattcaa ttggtatata aataataaat gatagttaaa ttttacctta gaggctaatt
    11581 aggtgtttag tcaaagctaa tgcctttaga atacaaatgt attctaaagg catttttact
    11641 atgtattttc atttatatta ctaaacatta tctattttta tatacatttc tatgtatttt
    11701 attttcatca aatcggtcta taaactcatt tttttcttca ctatatccaa tagatataag
    11761 tgcataagga actaatttta atggtaagtc taaagtttgt ctaactttat ttaccacttt
    11821 atttttagga aatactcctg cccaacaagc agctagacct tgattagtaa cttctaataa
    11881 taaattttgt gtgcaagcac ctaaatcttg tatccattta ccaggtttta agaatttatc
    11941 tctatttcca agcactacta tacataatgg tgcaaattct atatgctttg ctctatgctg
    12001 tgactttgag agctgtttca gcagttcctt atcatctact ataataaatt cccaaggttg
    12061 agcatttttt gatgaaggtg cttgcatagc tgattttagt atttcagtta ttttatcttc
    12121 ttctatattt ttatctatat atgttcttat tgaacgtcta ttttttataa cttctaacat
    12181 acagattctc ctttaaataa aattatttct atttatataa tatcattact ttaaatttta
    12241 gctattactt atataaagaa taaactttgt gttggtttta tctaagtaaa agtaacattc
    12301 agaactaaaa aacaagacta taaatccaaa gtattaatta aaaaagaagt aataaaaaat
    12361 aatatacaag atttaaaaaa gagtattggg cttaaaattt aattagaaaa ccaattttga
    12421 gataatctgt tttttatttt aacaaaaaaa cacaaataaa gttcgatacg tagcgaatga
    12481 aaaaattaca agaaatattt tttttaaaaa atttcaaaaa agagttgata atatatgtat
    12541 attaatataa aatttaaggt gtataattcg tataataata cgaatgattt gtagtgtaaa
    12601 ataacttata aacggagagg ggaagtctaa tgaaagtagc agtagttatg ggttcaaaat
    12661 cagattatcc aaaattagaa gaagggataa aactgcttga aaaatatgga atagaagttg
    12721 tagcaagagc attatcagct catagaacac cagaacaact ttcaatattc ctaaaagaaa
    12781 tagaagatga tactgatgta ataatagcag cagcaggaaa agcagcacac ttaccaggtg
    12841 taatagcttc acaaacatta attcctgtaa taggattacc tattaaatca tcaactatgg
    12901 atggactaga ctcactttta tcaatagttc aaatgccaaa aggaatccca gttgcaacag
    12961 ttacaataga cttaggttta aacgcagctt tattggcatt acaaataatg actttaaaat
    13021 acccaaaatt aaaagaggat ttgaaatcat atagagaaga gatggcacaa aaggtgttag
    13081 aagacgacaa gaatttaagg gggtagcaga aatgttatta tatgaaggaa aagcaaaaca
    13141 agtatattct acagataatg aaaatgaata tgttgtttat tataaagatg atgcaacagc
    13201 atttaatgga gaaaaaaaag cagaaatatc ttcaaaaggt atactaaata ataagatatc
    13261 aacaataatc tttgaaatgt taaaagaaaa taatataaat actcacttta taaaaagttt
    13321 atcagataga gaaatgttag ttaaaaaagt agagatttta ccattagaag taatagtaag
    13381 aaatattgct gctggttcta tctgtaaaag agttggtctt gaagaaggtg tagttttcga
    13441 tgagccaatt tttgaaataa gctacaaaaa tgatgcttat ggtgacccaa tgctaaatga
    13501 tgattatgca gtggcaatga agttagcaac tagagaagag ttaaaattct taagagaaga
    13561 aactttaaaa ataaatgagt tactaaaagc atttttctta aaattaaacc taaagttagt
    13621 tgactttaaa atagaatttg gtaaggattc tgaaggaaat ataatattgg cagatgaagt
    13681 atcaccagac acttgtagac tttgggatgt aaatacaaat gaaaagttag ataaggacag
    13741 atttagaaaa gaccttggag accttgtaga aggttatacg gaagtacttt caagaatgaa
    13801 taataaatag gaggcaaatg tatgtgtgga gttttaggga tttactctaa taaagatgta
    13861 actaaagaac tatattattc tttatattct atgcaacaca gggggcaaga aagctgtggt
    13921 ttagctcttt tagatgatgg agaaattaag tacaaaaaag atatgggatt agttggagat
    13981 gtttttaagg aaaatgaatt atctaagtta aaaggaaata tagggattgg acatgttaga
    14041 tattcaacag ctggaggaag tcatgtttct aactgtcaac ctttagttgg aagttgtaga
    14101 aaaagacaat tagccatagc tcataatgga aatctagtta atgcaaatta tttaaaagat
    14161 atgctagaag aagatggata tatgttccaa actaattcag atacagaagt gattttatat
    14221 atacttgcta gatattacaa aggggatata gtagaaagtt taaaagtgac aatggattat
    14281 ataaaaggtg catatgctct tgtaataatg agtcaagaag aattggttgc agttagagac
    14341 ccacatggat tcagacctct tgtacttggt aaaaagggtg atgaatatat atttgcatca
    14401 gaaaattgtg caatagatat acttggcgga gaagttataa gagatgtaga gccaggagag
    14461 ataatagtag tcaaagatgg agaactaaaa tcatattttt attcagaaaa ttataaacca
    14521 gttaagaaaa gttgtatatt tgaacacata tactttgcaa gaaatgatgc aactatagac
    14581 aatgtaaatg catatgaatt tagaattaaa tgtggtgaga gattagctca gaatgaaact
    14641 gtaaaggcag atatggtagt tccagttcca gattcaggtt ggccaggagc tattggttat
    14701 gcaaatgcta gtggattaaa aataagtgaa ggcttagtta aaaatagata tgtaggaaga
    14761 acatttataa aacctacaca agaagaaaga gaaatagcag taaaaataaa attaaatcct
    14821 ctttcaacaa taataaaagg aaaatctata attttagtag acgactcaat tgtaagagga
    14881 actacatcta aacaattagt aaaatcttta agagaagcag gagcaaaaga aattcatctt
    14941 agaataactt ctcctccagt agcttactct tgttactatg gaatagatac tccaaatcgc
    15001 tctaaattaa ttgcatcaag taacaacgta gaagaaatga gagaatatat tggatgtgat
    15061 agtttaaaat tcctagatat agaaggaatg ttagatgcaa cagaacataa gtctactttc
    15121 tgtaaagctt gttttgatgg agaataccca gttaagaaaa ttgataagga ggaactactt
    15181 tcatgttaac atataaagaa tcaggtgtag atatagatga aggaaataga gcagtagacc
    15241 ttataaaagg taaaataaaa ggaacttatg atggaaatgt agttggagat ttaggtaact
    15301 tcagtggatt atacagttta aaagattttg taggtatgaa agaaccagtt ttgcttgcat
    15361 ctacagatgg tgttgggact aagttaaaaa tagctcagat gatggacaag catgatactg
    15421 ttggaataga tttagttgca atgtgcgtga atgatttaat ttgtcaagga gcaaaaccat
    15481 tattcttcct tgactatata gctcttggga aattagtgcc tgagcatatc gaaaaaatag
    15541 ttggtggaat tgcagatggt tgtaaaatgt ctggttgtgc actaattggt ggagaaactg
    15601 ctgaaatgcc tggaatgtat ggagaagatg actatgattt agcaggattt tctgtaggaa
    15661 tagcagacaa agaaaagatt gtttctggaa acaatgttaa atcaggagat gtattggttg
    15721 gtatatcttc aagtggagta cacagcaatg gattttcttt tataagaaag atatttttag
    15781 aaacttacaa ttataaaatg gaacaatatg ttgaagaact aggaatgaca gttggagaag
    15841 cacttttaac accaactaaa atatatgtta aattagcttt agatgtatta gctaaacatg
    15901 acataaaagc tatagctcac ataactggtg gagggcttat agaaaatata acaagagtta
    15961 tacctaaagg gttaggacta gatatcaata aaaaatcttg ggagaagcct cctatattta
    16021 aaatgataga aggttttaat gctgttgatg agagagaact tcataagagt tttaacatgg
    16081 gtattgggct agttttaata gtagataaag aaaatgctga tgatgttgta aactttataa
    16141 ataatagaga aaatgacaat gctgcttatg tagataaaaa atatagtgaa ttattagaag
    16201 ataaagctta tataattggt gaagtagtag atagtcatga aggtgtagaa ttatgctaaa
    16261 tataggagtt ttaatatctg gtggaggaac aaatttacaa gcagttatag atggtactga
    16321 gtctggagaa ataaaaggtc aggttaaagt agttatctca agtaagcaag gtgcttatgg
    16381 gctagagaga gctaaaaatc ataacataaa agcaatttgt gaaactgatg aagacaagat
    16441 aatagaaatt cttaaggaaa ataaaataga tttagtagtt ttggctggtt atttaaaaat
    16501 aatcagccca aagctggtta acgagtttag aaacaaaatg ataaacatac atccatcatt
    16561 aattccttca ttttgtggag ctggattcta tggagaaaaa gttcatcaag gtgttataga
    16621 ttatggagct aaagtaactg gtgctacagt tcattttgta gatgaaggtg ctgatactgg
    16681 accaatcata atgcaagatg tagttaaggt aaatcaagat gatgatgcaa agacacttgc
    16741 aaaaagagtg ttagaagttg aacataggat tttaaaagaa agtataagtc ttttttgtga
    16801 aaataaatta aaacttcaag gtaggagagt gtttataaat gagtaagaga gctttaataa
    16861 gtgtaactga caagactggt gtagtggaat ttgctaaaga gttaaataaa ttagattatg
    16921 aaattatatc tacaggaaat acatttaaaa cattaaaaga aaatggtgtt aatgtaatgc
    16981 aagttgaaga tgttacaaat tttccagaaa tattagatgg aagagtaaaa acattaaatc
    17041 catatataca tggtggtata ctttataaaa gagataaaga atctcatgta gaaactgtaa
    17101 atgaacacaa aatacattca atagatttag tagctgtaaa tctatatgat tttgaaggaa
    17161 ctttaaaagc tggaaaaagt catgatgaaa taattgaaaa tatagatatt ggtggaccat
    17221 ctatgatacg ttctgctgcc aaaaactata aggatgtaat agtagtagta gatataaaag
    17281 attatgattc tataatagaa aaattaaaaa cagatacaat gacattagaa gacagaaaaa
    17341 aattatcata taaagctttc tcaactacag gaagatatga tgcgttaata tctagttatt
    17401 ttgctggaga agttggagat acgtatcctg acatattaaa tttaactttc caaaaagaac
    17461 aaactttaag atatggagaa aatccacatc aaaatggttt cttatattca cagtcaaatg
    17521 caaaaaatcc aatcttaaat tatgagcaat taggcggtaa agaactttct tttaacaact
    17581 taaatgattt acatggatgt ttagaagtaa tgagagaatt taaagatagt gaagaagtag
    17641 tttcagtagc tataaaacat gctaattcat gtggggtagg tttaggaaaa gatgcttttg
    17701 aagcatatac aaaatgttat gaagcggata aggtttcaat atttggagga atagtaggaa
    17761 taacttctac tatagataaa gctacagcag agaaattaaa tgaaatattc ttagaaatag
    17821 tagtagcata tgattttgaa ccagaagctt tagagatact taaacaaaag aaaaatctaa
    17881 gaatattaaa attagctaaa atagaaaata gtttacaacc atatgaaatg aaatatttag
    17941 atggaaaatt attgatacaa gatagaaaca atatattagc agaaaaaagt gaaaatgtaa
    18001 caaaggaaaa accaacagat gcacaactta aggacatgga atttggtatg agagtagtaa
    18061 aaaatatgaa atcaaatgca attgcagtag taaaaaatgg acaaactcta gctttaggtt
    18121 gtggacaaac atcaagaatt tgggcattaa aaaatgctct tgaaaataac aaagataaag
    18181 attttacagg agctgttttg gcgtcagacg catttttccc atttgatgat tgtgtaacat
    18241 tagctcatga atatggaata tcagcagtag ttcaaccagg tggctctata aaagataaag
    18301 attcaataga agcttgtgac aagtatgata tggttatggt atttacagga ataagacact
    18361 tcaaacacta aggaggatat tatgaagata ttggttgtag gcggtggcgg aagagagcat
    18421 gctatatgct ggaaactaag caaagaaaaa aatgtagaaa aaatttattg tgcaccaggt
    18481 aatgcaggaa ttgcaaacgt agcagaatgt gtaaatatag gtgatactaa tatagaagaa
    18541 cttttaaaat ttgccaaaga aaatgaaata ggtctgacaa tagtaggacc agaagtacca
    18601 ctagttatgg gaatagtaga tgagtttgaa aaagaaggat taagagtatt tggacctaat
    18661 aaaaaatgtg ctcaacttga aggaagtaaa gctttttcaa aagaatttat gataaaacat
    18721 aacataccta ctgcaaaata taaagaatat acaaacttag aagaagctat atcagaaata
    18781 gatagttttg gatatccagt agtaataaaa gcggacggat tagctgctgg aaaaggtgtt
    18841 gtaatacctg aaaatagaga agatgctata gcaactttaa aagaaatgat gtcagataag
    18901 aagtttggag ctgctggaga taaaatagta attgaagagt ttttaaaagg aatagaaact
    18961 tcaattctag catttgtaga caatgataca atagttccta tggcaagtgc aaaagaccat
    19021 aaaaaagtaa acaactatga gcaaggtcca aacactggag gaatgggaac tttttcacct
    19081 agtgaaatat atacagaaga attagcaaat aaagtaaaag agacagtatt agaaaaaact
    19141 ttagaaggtt tcaaaaaaga tggacttaat tttaaaggta ttttatttgt tggtcttatg
    19201 ataactgaag atggagaaaa agtacttgaa tataatgtaa gatttggaga ccctgagaca
    19261 caatctgttt tatttagatt agaaacagat ttacatgaga taatggaagc tatactagat
    19321 aataagttaa aagatataga aataaactat agtgatgatg aagctgtatg tgttatgctt
    19381 acatcaggag ggtatccaga cagttatgaa aaagggaaaa ttataactgg tcttgaaaac
    19441 ttggatgatg atatagtagt attccatagt ggcactaaga tgtttgatgg taatttggtt
    19501 accaatggag gaagagtaat tggtataact gcaaagtcaa ctagagttaa ggatgcagca
    19561 gaaaaagttt atgaaaacat aaagaagata aactttgaag gaatgcacta tagaacagac
    19621 ataggaagat aatttttcta aaatggagga taaggtatgt tgaatactga aaataaagac
    19681 tcaatggtta gaagagtatt ggttgaaaaa agagaaggtt ttgaccttga ggctaaagct
    19741 ttaaaaaaag acttagtaga aagtttacac atagataata tagaaaattt aagaatatta
    19801 aatagatatg atgtagaagg aatatcagaa gaagtttatg aaaatgcagc aaagacaata
    19861 ttctctgaac caaatttaga tgtagtatat tatgaagaaa taccaaaatt aaatgatgaa
    19921 agagtatttg caatagaatt tcttcctggt caatacgacc aaagaggtga ttgggcagct
    19981 caatgtgtac aaattgtaaa tcaagggata agacctgcta ttaatacagc aaaagtttat
    20041 atattatcag gcaaaataac tgatgaagag ttttctaaaa taaaagatta ctgtataaat
    20101 ccagtagata gtagagaagc atctttagag aaaccagaaa cgttaaaaat ggaaactgaa
    20161 ataccaacaa cagttgaagt attagatgga tttatagatt tagatgaaaa tggattaaga
    20221 acatttgtaa gtgaaaaagg attagcaatg actttaggag acttacaaca cgttcaaaaa
    20281 tactttaaag atacagaaaa gagaaatcca actataacag aaataaaagt attagatact
    20341 tattggtctg atcattgtag acatactact tttatgactg aaatagaaaa tgtaaagata
    20401 gaagatggta agtttaatga tatagtaaaa gaagcgtatc aaatgtatct taactcaaga
    20461 gacaatgtat atgtgaacag acataaagat atatgtttaa tggatatagc cactgttgca
    20521 gtaaaagaat taaagaaaaa tgggaaatta aatgacctag atgaaagtga agaaataaat
    20581 gcatgtagta taaacgtaga tgttgaagtt gatggtaaga tggaaaaata tctagtaatg
    20641 tttaaaaatg aaactcacaa ccatccaact gaaatagaac catttggtgg agcagctact
    20701 tgtttaggag gagctataag agacccatta tcaggaagaa gttatgttta tcaagcaatg
    20761 cgtgttacag gaagtgctga cccaagaacg actttagaag atactttacc tggaaaactt
    20821 atgcaaagaa aaataactac agaagctgct catggatata gttcatatgg taaccaaata
    20881 ggtcttacaa ctggacaagt tgcagaagta tatgatgaaa actttgttgc aaagagaatg
    20941 gaaataggtg cagttatagc agcagcacca aaagagaatg tagtaagaga aagacctgaa
    21001 gcaggagatg taatcgttct tcttggagga aaaacaggaa gagatggctg tggaggagca
    21061 actggttcat ctaaagaaca tagtgaagag tcaatcttaa cttgtagtgc agaagttcaa
    21121 aaaggagatg ctcctaacga aagaaaaata caaagattct ttagaaataa agaagttgct
    21181 caaatgataa aaagatgtaa tgattttgga gcaggtggag tttgtgttgc tataggagag
    21241 attgctgata gcttagatat aaacttagac ttagttccta aaaaatatga tggacttgat
    21301 ggaactgagc ttgcaatttc agagtcacaa gagcgtatgg cagtagccat aaaaaaagaa
    21361 aataaagata aatttataca attagcagta gaagaaaact tagaagctac gcatgtagct
    21421 acagtaacag atacaggata tttaagaatg ttctggaatg gaaaagcaat tgtagatata
    21481 aatagagagt ttttagatac aaacggagta aaacaaacta ctgatgttca tgttactaaa
    21541 gtagatgaag aaaatacatt ctttagctct aatgaaatag taaaagatgt taagtgtgca
    21601 agtatgaaag acaagtttac aaaagtacta tctgacctta atgtttgttc tcaaaaagga
    21661 ttagtagaga tgtttgataa tacaattggt ggtaatacag tacttatgcc atttggagga
    21721 aagtatcaag cgactccaac acaaggtatg gttgctaaga taccagtact tggaggagaa
    21781 actaatactt ctacaataat gacttatgga tacaatccaa aggtaggaaa atggagccca
    21841 ttccatggtg ccttgtatgc agtagtagaa tctgtgtgta aattggttgc tattggagga
    21901 aattatagta caacaagact tacattccaa gagtattttg aaaaacttgg taacaatcca
    21961 gaaaaatggg gtaaaccatt ctcagcactt ttaggagcgt tttatgcaca aagtaaattt
    22021 gagatacctg ctataggtgg aaaagacagt atgtctggta catttaaaga tattgaagtt
    22081 ccaccaacat tagtttcatt tgctgttgac acagtagatg cgaagaaagt agtatctcca
    22141 gaatttaaaa aagcagactc aaaagtagta atgttatgtg taaacaaggc agaaaatgat
    22201 gttgtagatt ttgaggaatt aaagagaaac ttagataaag taagagaact tatacatgga
    22261 aataaagttt tatcaacata tgcattagga tttgcaggtg taggtgaagc aataagtaaa
    22321 atggcttttg gtaataaaat aggatttaag tttagtgaag aagctgaaaa agcatttaca
    22381 gataataaat tatttgaggc tagttatgga aatatagtac ttgaattagc aaatgatgat
    22441 ttaagtatgt tagaaggata caattatgtt gtgattggaa gtacagttaa agaagctagt
    22501 atatttatca aaggtgaaga acttgcatta gatgaattat ataaagcaca ttgtagtact
    22561 ttagagccta tattcccaac taaaacagaa gaagtaaaat caaagataga aactataagt
    22621 tatatatcac aaggagaagc taaaaaatca tcattaagta tagctactcc aagagtattt
    22681 ataccagcat tccctggaac aaactgtgaa tatgactctg caagagcatt tgaaagagca
    22741 ggagctaatg caagtataag agtatttaag aatttaactt ataaagacat agaagattct
    22801 atagatacaa tagtaaacga aataaaatct tctcaaataa taatgttacc aggtggattt
    22861 agtgctggtg atgagccaga tggttctggt aaatttatag ctactgtatt tagaaatcct
    22921 agagtgcaag aagctataaa tgaattttta actcaaaaag atggactaat gttaggtatc
    22981 tgtaatggat tccaagtatt aattaaatta gggttagttc catatggaga aataagagtt
    23041 ccaagtgaaa gtgctccaac acttacttac aataatattg gtcgccatca agctaagatt
    23101 gctagaacta gaatttcatc taataaatct ccttggttag ctcaaactaa tgttggagat
    23161 attcataata tagcaatttc tcatggagaa ggtaagtttg ttgccagtga agatgttatg
    23221 agagaattaa ttgctaatgg acaagtagca actcaatatg ttgactttaa taatgaagct
    23281 acttatgata ttgagtttaa tccaaatggt tcattctatg ctgttgaagg tataactagt
    23341 gctgatggta gagtgtttgg taaaatggga cattctgaaa gaattggtga ggaagtatat
    23401 aagaatatta taggtgaaaa agaccaaaag atatttgaat ctggagttaa atattttaga
    23461 taaagctttg atgtttaatt gatagctaga atatataatt tagatattta gatttaaaga
    23521 gatgtaataa tatgatgata atcatttaat attacatctc ttttttattt atctaagaaa
    23581 taataagttc aacctaagtt aaaatacaag ctgtgttata attaattatt aagtaaaatt
    23641 gaatatttat tggagggcaa cataattaat gaaaatatta ataacagggt ctaatggtca
    23701 attaggaaaa gaattggtta accaattaga agcaatcaat caaagtataa accaaccaaa
    23761 atatgttata ttagctacaa caagaagtga tttggacata tccaatcaga ctaatgtaga
    23821 taattttatt ttgcataata aacctgatgt agttgtaaac tgtgcagcat atacaaaggt
    23881 tgatgcatgt gaagataata tcgaaattgc atacaaaata aatgctttag gagtgagaaa
    23941 tctagcaata gcatcagaaa aagttaatgc taagcttatt cacatatcaa ctgactatgt
    24001 attcaatggt ttttctaaat atccatatag ggaagacaat aaaactgaac ccaattctgt
    24061 atatggaaaa agtaaactta tgggagaaaa atttgttgaa caattctcac ataagtactt
    24121 tatattgaga acagcatggt tatatggtaa tgggaataat tttgtaaaga ccatgataaa
    24181 actttcttta gaaaataaag aggttaatgt ggttaatgac cagtttggaa ctccaacaag
    24241 tacagtagac ttagcaaaaa ttataataag aatcatggaa acagaacatt atggagttta
    24301 tcatgctaca tgtgaaggtg agtgtagttg gtatgatttt gccaaaaaga tatttaaact
    24361 aaaaaatata gatataaaag taaatccaat taagagtaac gaatttaaat gtaaggctcc
    24421 aagaccacta tattctgtat tggataattt tatgttgaag ttaattggtt taaattcttt
    24481 tagaaagtgg gaagaatcca ttgaagaata tttagaaaga tatgatataa atgaaaagta
    24541 aatgtattat tttgagaaaa gaaaataaga tattataaaa aatataaata tttcttttat
    24601 ttatccgata atcataatat gacaaaaaca aatttaagga tggaaaaaga tgaaaggaat
    24661 tattttagca ggagggtctg gtacaagact atatcctata acaaaatgta tatcaaaaca
    24721 aacacttcca atatacgata aaccaatgat atattaccct atgtcggttc ttatgttggc
    24781 agggatacaa gatatattaa taatatctac accaagagat ataaaagcat ttgaagaatt
    24841 atttggagat ggaagttcac tagggcttaa cataacatat gcaattcagg agaaagcaaa
    24901 tggaattgca gaagcgttta taataggaga agaatttata ggaaatgaca gagtgtctct
    24961 tgtattaggg gataatatat tttatggata tggatttagt gaaaggttgg agaatgcagt
    25021 taaaagaaaa ggagcaacta tatttgggta tcatgtaagt aatccaaatt cgtttggagt
    25081 tgtagaattt gataaggatt ttaatgtatt gtcaatagaa gaaaaaccta cagttcctaa
    25141 atctaattat gctataccag gattatattt ttatgataat gatgttgtag agatagcaaa
    25201 gctagttgaa ccgtcagata gaggtgaatt agaaataacc tctataaaca gtgaatatct
    25261 aaaacgagga aaactaaaag tggaacttct aggaagaggt atggcttggc ttgatactgg
    25321 tacacataaa ggtctattgg atgcttctaa ttatgttgaa gtggttcaaa caagacaggg
    25381 actgtatata gcatgtttag aagagattgc atatacaaaa ggatatataa gtagagaaca
    25441 attaatgaaa ctagccaagc cactgataaa aactgaatat ggtcaatatc tattaaaatt
    25501 ggctagtgaa gatatgtaat atggtagata aaatttatta taaattttat taagggagtt
    25561 tattataatg ggaaaaatca atgttataaa gactaaaata gaaggattat atatagtcga
    25621 accaaatgta ttttatgatg aaagaggata ttttatggaa agctataata aaaaggattt
    25681 tatagagcag ggtcttgata tgtgttttat tcaagataat gagtctagct caagaaaagg
    25741 cgttttaaga ggaatgcatt ttcaggttaa atatcctcaa ggaaaattag tcagagttac
    25801 agagggagaa gttttcgatg ttgcagttga tttaaggaaa gattcacaaa catttgggaa
    25861 atgggaaggt gtaatattgt ctgataagaa taaaaaacaa ttttatattc cagaagggtt
    25921 tgcacatgga tttttagttt tatcagaaaa agcagtattt agttacaaat gtacaaatta
    25981 ttattaccca gaatttgaga atggctttat atggaatgac aagcaaatat ctattgagtg
    26041 gcctttaaaa ggaattgaag aaatattttt atcagaaaag gacaaaaaac aaaaaagttt
    26101 taaagatatt tgtacaagac gttaataaaa atttattaga attaacattt aggagaaaaa
    26161 atatgaaaaa aatactgata actggaggag caggatttat tgggagtaat tttatacatt
    26221 atatgcttaa caagtatgta gattatttta ttgttaacct agacttgttg acttatgctg
    26281 gtaatttaga gacattaata gaaatacaag acaattccaa ttataaattt gttaaaggag
    26341 atatttcaaa tagggagcag gtgtataagc tatttgaaga agaaaggttt gatatagttg
    26401 ttaactttgc cgctgaatct catgtagata ggtcagttga gaatcctgat ttatttatta
    26461 aaacaaacat tataggaaca caagtacttt tagatgcatc tataaaatat ggagttaaaa
    26521 ggtatcatca aatatctaca gacgaagtgt atggtgattt accaattgat agaaaggatt
    26581 tattctttac agaacaatct tctatcaatc caagttctcc atattcagct tctaaagcat
    26641 cagcagattt attggtaagt tcttattata gaacatatgg attgttaaca actatatcta
    26701 ggtgttccaa caattatggg ccatatcatt ttcctgaaaa attgattcct cttatgattt
    26761 taaatgcttt ggaaaacaaa caattgccag tatatgggaa tggggaaaat gtaagagatt
    26821 ggttacatgt atatgaccat tgtactgcta tagacttaat aatacataaa ggaaatatag
    26881 gggagattta caatatagga ggtcataatg aaagaagtaa tctagaagta gtaaaaatga
    26941 tattaaatct tttaggtaaa tctgaagagt taatatccta tgtaaatgat agacctggtc
    27001 atgatttaag atatgctatt gatgcaacta aaatagagaa tgagttaggt tggaaggcaa
    27061 aatatgactt tgatttgggt ataaaagaaa ctgttaagtg gtatatagaa aatgaatctt
    27121 ggtggaaagc tgttttatca gtataacttt aaaatttaga aaggggcgtt ttatattgaa
    27181 tgagataagt tcactaatta atatattagc attgactcaa ttatctggta gtaatactac
    27241 aaatcaatgt aattgtacat ataataattc atctggattt gatatgatta tgatgacctt
    27301 gttaaaagca ttatcacaaa ataatcaaca tacttctaat agctacaatt tattgtctaa
    27361 ttctgagaat ttatttaatg aacttgataa tgtagtaaat aataccacta gtagatttat
    27421 agatgttgat acaaaagata aaaatgtaaa gttgagaatt gaaaatgctg tagatcaagc
    27481 atcaaaaaaa tataacgtag attcaaatct tataaaagca ataattaaag ttgaatcaga
    27541 ttttaatcca aataccgttt cttctgctgg tgctaagggt cttatgcaac ttatgccaga
    27601 aaactgcaga gacttaggag ttacagaccc ttttaatata gaacagaata tagatgctgg
    27661 aactagacat attaaggaat acattgatat gtttggaggg agcatagaaa tgggattgat
    27721 ggcatataat ggtggtcctg gaagaatgaa aagtagagga gtagaatcaa tctctgacct
    27781 gtataaaatg ccaaaagaaa cacaaaatta tattcctaag gttatgaaat attatagagg
    27841 gtaggcttta ttatgggaat aaatatagat aagctaaaca taagtccaag tataaatatg
    27901 gaggttaaaa aactaaaaga gagtaataaa ttttctgaca aattaaactc tttaaaacaa
    27961 tcttcttcat tggaagatat aaaacgaaat ttggaaagtg taaaaaaggc aggagaaagg
    28021 cttgtactta ctcaaaacta tggcgatatt agtatatata aaaatgcagt aaaagaatac
    28081 ctaaaatctg ttgtagataa tatgtattca cttgataaaa atagtagctt ttgggagcat
    28141 cagtattata agaatgtaaa gattgttgat agtaaacttg aggatatgac tagtaagtta
    28201 attagtgaag aaaaagaaaa catagatatt gtttctactg ttgacatgat acaaggctta
    28261 ttgatagata tgtatagata aggttataca aggagaaaaa ttttatgaat agcaaaaaag
    28321 aggatatata tgaattgaat tttgggcaat taatagaaga aaaatctggt gttatagaag
    28381 aaaatcaaaa tgtttttaat gcaaaagtaa atgtagctgt ttctatagga aatacaacag
    28441 aaacaataaa aaatatatta gatttaaaag aaggctctat aataaaatta agtaagaatg
    28501 tggatgaaaa attagatata tatgcaaacg atagattgtt tgcttatgga gaaagcatta
    28561 ttacaaatga gaggttatct gtaagattat ctaaaataga agatccagat gtaaattagc
    28621 attttaaata gtatcccttt aggctattct gtatgagttt agctaagggg atatttttat
    28681 aaaaaattta aaatatgtgt gaattatata aatattttta ttttatgagc gataactaaa
    28741 ttataagtat gtaattttgg aggtgaaact atggatatta aaaatgtaag ttcaaatatt
    28801 gtagtgaata attatttaaa gaatacatct ggtataaaaa aagtggaaga ggttaaaaaa
    28861 attaataaaa cagataagat agagttatct aaatttgcaa aggaaatggc aagtgtgtca
    28921 aatatgagtg atgagaatat tagaaataaa aaagtcgatg aaataaaaaa tgcattagaa
    28981 aatggaactt acaaaataaa accaaaagaa attgcgaaaa aaatgataga ggatatgcga
    29041 ggataaagtc atgattacag acttaaaagt tataatatat gaagaaaaaa atataattag
    29101 taagatgatg gaattattaa aagaacaatt tgattatata gttgaaaaag acttagaaaa
    29161 tttaaatatg ttaaatccta aactagaaga tattagcagg gagcttgcat ccatagaaat
    29221 aaagagaaga caactttttg gtgatgatat ttcaatgagt gaagttgttg aaaatagtaa
    29281 tgatggatac ttaaaagaaa tatatacaga cttgaaacac attcttgctt tagctaaaaa
    29341 tcaacaagaa tcaaatgatt ctctaataaa gaaagaactt atttttacga aaaaaatgat
    29401 taatttcata aaaccagctg ataagcaaac tacaacttat aattcttatg gaaatattag
    29461 aaaataaata ttaggaggag aaatatggca ggattatttt ccattttaaa tacagctaat
    29521 tcaggaatga atgcgcacca aaaagcaata cagacaattt ctcataatat aagtaatcta
    29581 gatacagacg gttattctag gcaaaggacc gagtttgcca caaatagtcc aatgtatatg
    29641 cctagtttga gtaattcaat tgcaagagga caattaggga ctggagtaca tgtaacggat
    29701 gtaacaagag ctagaaatag tttttatgat taccaattta gggcagaagc tcataagtat
    29761 ggtaagacag tttcaaaata tgattattac aatactatag aaactatact aaatgaacca
    29821 tcagactatg gaatatctgc aggtatagat gattttttta aaggatggga gtcattatca
    29881 aaggatataa atagtgacag taaaaaaagt ctagtggtag aaaacgcatc taatttagca
    29941 actttaataa gtgaaagtta taagaagctt gataagttaa aagaagatat agattctaat
    30001 atagacactg agataaaaca aataaatgac atgttaaaaa gtcttgaaga tttaaataaa
    30061 tctattgata ttatatctgg ttctggctct acaccaaatg atttacttga tgaaagagat
    30121 agaattttag ataacttgag ttttaaacta gactttgaaa atagtgatgt taaaaatatg
    30181 cttgcagatg gtaaattaga acttaatgaa ttaaaaaatc cagatggaac ttggaaaaca
    30241 ggtatatcag ggaccttaca aggcttgttt gaaatgcatg gtaagattga tacatataaa
    30301 agcgatttaa aagatgtatc tgatggatta gctaaacaga taaatgatgt ttataatacg
    30361 tctgcaggaa taacagtaac agattttttt ataacttcaa atgtagatgg tgaagatatt
    30421 ataaagataa atccagctat aaagagtaac ccaaatgaat taaagcttac tgctgatgaa
    30481 gcttcaaaaa ttgctaagtt aaaggatgaa aaaatagata ttggggtggc tggtggaaaa
    30541 gtaagtacaa taagtgacca ctataaagcc tttgcagaat caatcggttt agattctcaa
    30601 aaagtaaatc aagatgaagc aaatcaacgt aaaattataa ataatattga taactcaaga
    30661 atgagtgttt caggtgtatc tttggatgaa gaaatgacag agcttataaa aatacaacgt
    30721 tcatatcaag ctagtgcaaa agttatgtca acagctgtgc aactactgga tgttgtaata
    30781 aatggaataa tttaatagaa gggggaattt ataatgagag tcagtacagg tatgatgtct
    30841 agcagctatc taaactcact acaagataat ctacaaagat tggataaggt taatagacaa
    30901 gttaatacaa caaaagaaat aaacaagcta tcagataatc catataaagc aataaagata
    30961 ttaaactcaa aaagtgaaat aaagactatg gagacttatg ttgagaattg taaagataca
    31021 gggaattggt tagaaactac tgatactgca ttagatcagc ttggaaaatt attatcagac
    31081 ataaagaaaa ctttggtggc aagtggtgat ggtgcatact cagatgatga attaaagact
    31141 cttagtaatg aaactaatga aaaaatgaaa gaaattgcaa atgctttaaa tgcaacacat
    31201 gaagggaagt acatattttc aggttcaaat acgggggtac cacctgttga atgtatagat
    31261 aatgctgatg gttcagtgag tttaaagttt aattctagtc taaatcttaa taaattaaat
    31321 gactctttga gtatggatat agctcaagga ataagtgtag attataacgt taaattgagt
    31381 agccttggat ttgacccaac aaaaactgac ccatttgaag agttaaataa catatcaaaa
    31441 aaattagcaa atccagatgc tgatgctata aaagagctta caacaacttg tttgggcgat
    31501 atggaacaac taatagaaaa tacagtaaat gttaggtcta tatatgggac aaaagcaaat
    31561 acagtagagg ctatgaagga aaaaaacgat gatagtttga tacagttaaa ggatattttg
    31621 tcacaaaatg aagaaataga ttatggtgaa aaacttgttc aattaaaggc agcagagtta
    31681 acttatcaag cttcactaca aacaggagga aagttattta atgtatctat attagattac
    31741 atataataaa ataacgcaga tatgatgaag gttacattaa aaaaaggtat attaggtttt
    31801 gaaaatttaa aagaatatga gcttttagat atagaagata atgattattt aaaagaattt
    31861 aattctactg aagaagaagg tataggattt gttgttgtat ctccatttga gattatcaat
    31921 gaatatgaaa tagttttaaa tcaggaaaca atagaaaaac tagaagtgaa atctccaaag
    31981 gatgttgtat tatttaatat aattactctt ggtcagatat ttgaagaatc aactgtgaac
    32041 atgaaagctc ctatagtgat aaatataaaa actaattttg gaatgcaaat aattttacag
    32101 gatgataaat attcaataag gcatccatta ttgagaggtg atagtggatg ctagtaattt
    32161 caagaaaaaa agatgaagca gtacttatag gagaaagcat agaagtaaaa attgtagggg
    32221 tagatggaaa caatgtgaaa ctagctatat cagcgcctaa caatataagt atattaagaa
    32281 aagaaatata cgaaaaagta aagagtgaga atataaaagc tacaaataaa aatataaaaa
    32341 ttttaaagtc attaaaataa taagcttgga ggaagtaata tatgtatgga gaaaatcctt
    32401 ataattctta taaacaaaat gctgttttta tggcatcaaa ggaacaattg ttacttatgc
    32461 ttgttgatgg agcagtaaaa tataccaaaa tagccaaaac agctatctta gataaaaata
    32521 cacaaaaagc gcatagagag cttataagag ttcaggatat atttacagaa ctaatggtta
    32581 cattagacca aaatgcaggt caatgggcaa aggatatgta cagagtttat gattttgtaa
    32641 gatatgaact ttcaagagct aatattagaa aagacattca aataatagat aatgtgttgc
    32701 ctgtaataga acaaattaaa gatacttggc atgaagctga taaaaaaagt aaagaagaaa
    32761 gaagtaggta caaataatgg aattaaattt agctgaatta gataagttat caaaagagga
    32821 attactattg atgcttgtag atggaacagt aaaatatacc aatatatcca aagaagctct
    32881 tttaaataac gactatttga aagcacataa tgaacttgta agagttcaaa atatatttac
    32941 agaactaatg actacattag accaagatgc aggtcaatgg gcaaaggata tgtataaagt
    33001 ttatgaattt ataaaatctg aattagcaat agctgatgaa aataaagata ttaaaataat
    33061 tgatgatata ttgccaatag taaaacaaat tagagataca tggcatgaag tttacaatca
    33121 actaaaaata taattggatg gagggataaa ggtatgtcaa gtataagtcc tataagagtt
    33181 acaggtcttt caggaaattt tgatatggaa ggcataatcg aagctagtat gattagagac
    33241 aaggaaaaag ttgataaagc aaaacaagaa caacaaatcg ttaaatggaa gcaagaaata
    33301 tatagaaatg ttatacaaga atcaaaagat ctttatgata aatatctaag cgtaaattct
    33361 cctaatagta tagtaagtga aaaagcatac tcttctacaa gaataaccag ttctgatgaa
    33421 agtattatag tagcaaaagg ctcagctggt gcagaaaaaa taaattatca atttgcagtt
    33481 tctcaaatgg ctgaaccagc aaaatttact attaaattaa attcaagtga acctattgtt
    33541 caacagtttc ctccaaatgc tagtggagcg agttctttaa ctataggaga tgtaaatata
    33601 ccaatatctg aacaagatac tacaagtact attgtaagta agataaactc cctttgcgca
    33661 gataatgata taaaggcttc ttatagtgag atgacaggtg aattgattat ttcaagaaaa
    33721 cagactggtt cgtcatcaga cattaattta agagtaattg gaaatgacaa tttagctcag
    33781 caaattgcta atgataatgg tatcacattt ataaatgatg ctggtggaaa caaagtggca
    33841 aatgtatatg gaaagaatct agaagctgat gtaactgatg aacatggaag agtaactcat
    33901 ataagtaaag aacaaaattc atttaatata gataatattg actataatgt aaattcaaaa
    33961 ggaactgcaa agttgacttc tgtcactgat actgaagaag ctgttaaaaa tatgcaagca
    34021 tttgtggatg attataataa actgatggac aaggtctatg gtttagttac tactaaaaaa
    34081 ccaaaagatt atccgcctct tacagatgcc caaaaagaag atatgacaac tgaagaaata
    34141 gaaaaatggg aaaagaaagc taaagaaggt atacttagaa atgatgatga gttaagaggt
    34201 tttgttgaag atattcaatc tgcatttttt ggagatggaa aaaatattat tgcattaaga
    34261 aaactaggta tcaatgaaag tgaaaattac aataaaaaag gtcaaatatc atttaatgca
    34321 gatacttttt caaaggctct tatagatgat agtgataagg tatacaaaac actagcaggt
    34381 tattcttcga attatgatga taagggaatg tttgaaaagc taaaagatat tgtatatgaa
    34441 tattctggaa gttcaacttc taaacttcct aaaaaagcag gtatagaaaa aactgcttct
    34501 gctagtgaaa atgtatattc aaaacaaatt gcagagcaag aaagaaatat aagcaggtta
    34561 gttgaaaaaa tgaatgataa agagaaaaga ctttatgcta aatattcagc cttagaatct
    34621 ttgttgaatc agtattcttc ccaaatgaat tatttctcac aagcacaggg taattaatta
    34681 tggataaatt aaaagaaaaa ttaaatttat ataaagatat atctttacaa attataaatt
    34741 tgattgaaaa ggaagaatat ataaagataa gtattaagtt aggtgaaaga caagagatta
    34801 taaatagtgt aagtgaaatt gatagaaatg attttataca gctttataat agaatggaat
    34861 taattgaaat tgatagcagg ataagagata ttttacaagg acaattatta gaagtaaaaa
    34921 aagaattaca tgagtataag cttactaaac aagtgaacac aatgtattat aacttaaata
    34981 gagaaaaagt aaatattttt aataaaaaag tataaagtta tgtaccatct tgtccgatta
    35041 tataaatgaa gaattaataa aaaagattaa aagtagaaat gacaaggatg tcaactatac
    35101 taaggagggt aaaataatga gagttaatac aaatgtaagt gctttgatag caaataacca
    35161 aatgggaaga aacgtaaatg cacaaagtaa gtctatggag aagctatctt ctggtgttag
    35221 aattaagaga gctgctgacg atgctgctgg gcttgctata tctgagaaaa tgagagctca
    35281 aataaaaggt ttagaccaag caggaagaaa cgttcaagat ggtatatctg ttgtacaaac
    35341 agcagaaggt gcattagaag aaactggtaa catactacaa agaatgagaa ctttatcagt
    35401 acaatcttca aatgaaacta atactgctga agaaagacaa aagatagctg atgagttact
    35461 acaattaaaa gatgaagttg aaagaatatc aagctcaatt gagtttaatg gtaagaaatt
    35521 acttgatgga agttctacag aaataagatt acaagttgga gcaaactttg gaacaaatgt
    35581 tgcaggaaca tctaacaaca acaatgaaat aaaagttgct ctagtaaata cttcaagtat
    35641 aatgagtaaa gcaggtataa caagttctac aatagcaagc ttaaatgcag atggaacttc
    35701 tggaacaaat gcagctaaac aaatggtatc tagcttagat gtagctctta aagaattaaa
    35761 tacatcaaga gcaaaattag gggcacaaca aaatagacta gaatcaactc aaaacaactt
    35821 aaataatact atagaaaatg ttacagcagc tgaatcaaga ataagagata cagatgttgc
    35881 ttcagaaatg gttaacttat ctaaaatgaa tatattagtt caagcatcac agtcaatgct
    35941 tgctcaagct aatcaacaac cacaaggagt tttacaatta ttaggataaa ataattttgt
    36001 atattggata tagaagaaag ggtaaggctt tgctttactc ctttcttttt ttacaaatat
    36061 acttttgaaa ggaaaattta tatgttactt agtatagtta tgattgttaa aaatgaagaa
    36121 aaaatacttg aaaaaacttt aaaatcatta accacattaa gaaattctat agaaagtgaa
    36181 cttataatag tcgatacagg ttctacagat gatactataa aaatatctaa gaagtacacg
    36241 gaaaaagtgt attttcataa ttggaataat gatttttcta gtatgagaaa tatatcaata
    36301 tcctatgcta aaggtgaatg gttacttata ttagatgcag atgaaatact aattgattct
    36361 tcaactattg taaaattttt taaagatggt cttgataaaa aatttaattc tgcttcaata
    36421 caattaaaaa atctttactc atatgataaa aaattatatg gatattgttc agtgcttaga
    36481 ctttttaaaa acgttgattt tagataccat ggtaaagtac atgaacaacc aatatacaaa
    36541 aaccctatat ttaataatgt tgctgatttt gaacattatg gatatttgtt tgaagatgaa
    36601 gaaataagat taaataaggt gaaaagaaat gaaaaactat tatttcaaga gttaaaagag
    36661 aatgataatt ctccatatac aaactatcaa ttagggaaaa attttattat attaggaaaa
    36721 tatcaggagg ctttatacta tcttgagaaa tcttatgaat tatattctaa actagaattg
    36781 gcacctggtt acttgataac aagccttgta aaaacatatt tatatttagg aaaacataag
    36841 aagtgtgaaa gattgtgctt aaagtatatt aagaaagaca tgaataatat tgatatatat
    36901 tattatattg cacaagcaca agtagattta ggaaagtatg aaaatagtat agattcgtat
    36961 aagagatata tttacttgtt agataattat gaaataagta cacaagcaaa tagtttattt
    37021 tcagacactg atactgtagg gcttagagat gaggctatta ttacactgat aaagatttat
    37081 tataagcttg aaaaatatga gtttgtaatt tcagagtata ataacattga agatgtggaa
    37141 aagaaaaaga atgtgtactt tagcttattt atgtcactat ataaattgaa tagatttgaa
    37201 gatataaaaa attattataa agaagtttca aattctaaaa ttgaaaaaaa tagtttttat
    37261 agaaatatag aagaagttat aaataatatt aaagaggatg aaaaagagta tgtatataaa
    37321 atcctttgtg acattgaagg taattatggc attttaaatc aaataaggat aaataaatgt
    37381 gtatctatag ataaatgtaa agaaatactc aatgaagaaa aggaaataat ttatgcatat
    37441 attataaaaa tagcttttga agagaagatt gatttactag atatttttta tgaaatggaa
    37501 tatgtatgga tagagaaata tctaaaatat cttttagcat tagaaagaag ttttaattta
    37561 gtactatata agtacataat tagtcgtcca aatacatcag atatggaaaa gataagagta
    37621 tataaagcta tatctaaagt agttttagaa agtataagct taagtgatga aaaatataag
    37681 gagatttttt atctttatat aatgtattct tataagtaca taagatacat atatagcaat
    37741 ttaagtgatt ttgaattaat aaaatttgtt tgtaatgatt tagataagtt cactatagaa
    37801 tttaagcatc tacttgatat taaaaataaa gtaaataatg ctaatgaaaa attagagtat
    37861 atacatagta tgaggaaatt actaaatgag tatccttttt ataataaaat aataaaaata
    37921 cttataggtg aattagaaga aaatataaaa gaaagtgaag aatttaagga tttaaaagat
    37981 agttttatta ttagtataga aaatatgatt gaaactggca aaataaatga tgcgaaatta
    38041 ttggtagatg actattcaaa aacatttgtg gatgatataa agattttaaa tataaaggga
    38101 attttataca tgtttgaaaa taagcttgat aaagctgatt ttatgttaaa aaaggcatta
    38161 tcattagatg tagaaaatga agatactata tataatatag aatacttaaa aagtttaaga
    38221 taagtcaaaa ataggagaat tgaagaatga atataccaat agtggttaat gaaaaatcta
    38281 aagacataat aaaagattgg caatatacat gtacaaatga agatataaaa tttacaagca
    38341 taataatatt gacatataat caaatagaat atactaaatt atgtattgaa agtattagga
    38401 aatttacccc aaagaataaa tatgaaataa taataattga taataactct tctgatggaa
    38461 cagttgagtg gttaaaggga caatctgata taaaatctgt gtataataac aaaaacttag
    38521 gatttccaaa aggatgcaat caaggtattg agttagctac tggtgaaaac atattgttgt
    38581 taaataatga tgtaatagtt actccaaatt ggctctataa tttgaataaa gctttatggt
    38641 ctcaagataa tataggtgct gtaggaccta ttacgaatgc atgttcatat tatcagcaaa
    38701 ttgatgttga ttataagtca attgaggaca tgtttatatt tgcacacaaa ataaataaat
    38761 ctaatattaa cctatggaaa tatagattga agttagttgg attttgcatg ttaataaaaa
    38821 aaactgttct ggataatgta ggggttttag atgaattatt cacacctgga aattttgaag
    38881 atgatgattt atcttttagg atgatagagt caggatataa gttattatta tgccaggata
    38941 cttttataca ccattttgga agtgtgtctt ttaaagaaaa tcgtaataaa tatacagata
    39001 taatgtatat taatagaaga aaatttgaaa ctaagtgggg atttaatcca gaatatagtg
    39061 gaatgataag aacagatttg atttctaaaa tagatgatag tttggaggca aatattaatg
    39121 ttttagaaat aggatgcggt ataggggcta ctcttttaga aataaaaaat atatataaaa
    39181 atgcatcaat atatggaata gaaattagtg agtcagcagg taaacttgca aagtatagtg
    39241 cagatgtact tatagcaaat atagaaaaag taaaattgga ttataaaaaa gatttttttg
    39301 attatataat attgggagat gtacttgaac atttgattga cccatggaag atagtcaatg
    39361 aattgaaaca atatctaaag aaggatggtt atctggtatc tagtatacca aatattatgc
    39421 atgtttctgt tttaagaaat cttgtgttag gtaattttac atatgaagat tcaggaattt
    39481 tggacaagac tcatttaagg ttttttacat taaatgagat aacaaaaatg tttaatgata
    39541 gtaattacat aattaatagt attacagcta ctagtatgcc actttcggaa attgataata
    39601 gcttcattga tacaatatgt aaggaaagct gtaaagaaat gagacaacag tacgaatctt
    39661 atcaatatat agtaaaagcc tctaaaatcc tagatactaa aagatattct agtattagta
    39721 tgattaattt aaaatacgct ttaatgagaa ttgataatga attagatgta gatagtaatt
    39781 taagttatat atttgataat tataatataa ctgaaccatg ttttgttgat gatattgaat
    39841 atctaattga tacatttgtg ataaataaag caactctatt aaatagatta ggagttgagg
    39901 catttaacag aggtctagga gattttagta taaacatgtt tatgacagta ttagagatgg
    39961 atagagatga tattgactca atatataata taacaagtgt attatgtgaa ttagaagaat
    40021 ttgatactgc ttataattta attaaaaata gtagcgaaaa agtacagagt gaaagtgata
    40081 tacaagagat actttgtttt attgagggga agaaatatga ataatgataa gatatgtttt
    40141 ataacctgtg taaatgatga aaggctttat gaagaatgtc ttgtatatat aaatagccta
    40201 gacattccta aaaactttag tatagaaaca gtagctttaa gaggagccga ttctattgcc
    40261 tctgcttata ataaagctat gagagaaaca gattctaagt ataaggtata cttacatcaa
    40321 gatactttta taattaataa aaatttcata catgatattt tagagatatt taaaaaaaat
    40381 acagatgtcg gaatgattgg tgtagctgga gtaaaagata tgcctgtgaa tggaatttgg
    40441 tgggattctg ataaaaaagc agggaaagta tatgatagtc atacaggtaa aatggatatt
    40501 tatgaattta gtaactttga agaatgtttt aatgaagtta tggctataga tggattaatt
    40561 atgattactc aatatgatgt attttggaga gaggataagt ttgatgggtg gcatttttat
    40621 gatttgtcac agagtatgga gtttagacaa aataaataca aagttattgt accaaaacaa
    40681 aataagcctt ggtgtatgca tgattctgga gtagtaaata taaataatgg atatgatgaa
    40741 tataggataa aatttgtaaa agagtacata aatcttgatt tatatagaga aaatttttat
    40801 gaatttgata agaagaaagc aagtaccata cttaagagta ataagcatgt aatggattgt
    40861 atgaaagagg agcttacaga acaattaaga ttaaagaatt acaaggatgt tttaggtatt
    40921 gtttctaaaa ttgctcattt ttctgttttt aatcatactg gtttgtattc ttgtgaagaa
    40981 tgtgagagag cattgctaga atgtgcaaat aatttaccag aaatagaaaa tacgaaatta
    41041 tttacaaaaa aagatttaaa aagaagaaaa gtattacatg ttttaagtga aggatattca
    41101 acaggaggtc atacaagact agttaaaaat tggattgaaa ttgacaaaga ctctgttcat
    41161 tcagttgtaa ctacatggca atcagataca ctgccagact ggttattaaa agcaataaat
    41221 gatagtggtg gcgaagttat atctttggat ttaatttcag atgattattt aaaaagagct
    41281 gtagctttga ggaaaatagc ttatgactgg gctgatatag ttattttata tgttcatatg
    41341 tgggatacaa tacctgttgt tgcttttgga gttgatggga aaatacctat tttacatgtt
    41401 aatcactatg atagtacttt ttggttaggg acaagtattg cagatattgt cattgatttt
    41461 agcgaaacta gtcaattaat tacattagat aaaagaggca tagataaatc tgaaatatta
    41521 ccaatgccat taaaagaaaa agaagtattt tcaaaatctg aagttagaaa acgatataat
    41581 ttagaggatg atgtgacaat aatattgact attgctagtg aaagaaaata caatagtgta
    41641 aatgatatta attactttaa aattgctaaa acattgattg aaaatacaga taatacaatt
    41701 attattgttg taggagttga tacagagaat ctctattgga aaactttaag taatgttaca
    41761 gataatagag ttatatgttt tggaacaaca gcaaatatag atgattttta taagatttcg
    41821 gatatatacc tagagtcttt catggtagga agtcatactt caaaattaga tgcaatttta
    41881 tatgatttaa ttcctgttaa gtttaaaaat gaagtttcac caatttttac aaatatgtgg
    41941 aattttatag ataagtttga ttataagaat ataaaagagg ttatagacat gataagaagg
    42001 tacaatacta gtgaatttga cagggataag ataaaagcaa aacaatcgga aataaaacat
    42061 tttgttatag ataaacattg tattgaaata aaaaactata tagacaaaat atataatgaa
    42121 gttaatcatc ataaagttaa gtatgattta tataaaaatg atgaaatcga ggactatcag
    42181 ctttttgtag cattatatgg ctatatggta aaaaataaaa acatgtcata ggtggtaaaa
    42241 tgaacaatat tcatatcaat aaatttgaaa aaagctgtga aaaaaactgg gattattttg
    42301 tagaaaataa atctataaat ggtacatttc tgcaaactag aaatttcctt aattatcatg
    42361 aggagggaaa attcactgac cactcattaa taatatgtaa aggtgaagaa atactagcag
    42421 tcgtacctgc atgtgaaact tatgaagatg gtgaaagaat atttttttct catttaggga
    42481 gtacttttgg tggcattata ataagaagtg gttttaatga tattaggcat gtaaatgcca
    42541 ttacaaataa gttagaaata tatttacagg aacaaaattt cgataaagta tatttaaaaa
    42601 atacatcaag aatattttgt aaagaggata cttcattact agaatatttt ttatttaaga
    42661 ataattacat gttttatgat gaattaagta tgtttttaga attaagtaag tataaagaag
    42721 atatattagc caattttaaa tacagtaaaa gaagagattt taaatattct ttgaagaata
    42781 atcttacctt taaaagactg tatagtgatg aagatatagt ttgttttttt aatttacttt
    42841 ctaattgttt agatagtaaa ggagctaaag taatacattc agtagaagaa cttttggagt
    42901 ttaaaaataa tagattaaaa gatattgtag aattttatgc agtatatatt gatgacatta
    42961 tgatttgtgg gagcatggta tttaactttc aagaaagagt ttatcatact caatatctag
    43021 catcaaattc gacatataat aaatattatc caatgatatt tttatactat aatctaataa
    43081 aagatgcttt agagagaaat tttaagtatc tttcttttgg aattagcact ctaaatagag
    43141 gcaaatactt agatgagggt ttagctacat ttaaagaagg ttttggttca agtgcaattt
    43201 gtaacagaac atactataaa aatataaata agtgagaatc atgttttata gagtttttag
    43261 agtatagtaa atatctagta ctataatatt acataaaaat aattagttta taaagaaggt
    43321 ttgtatatga aaagattaat gattttaggc tcaattaagt attttgagaa tattgttatg
    43381 tcagctaaaa gagagggaat atacacaatt gtttgtgata atagaattga tactcctgcg
    43441 aaaaagattt gtgatgaagc aatagatgtt gatgtatttg attttgataa aataaagaat
    43501 atagctatag ataaaaagat agatggaatt ttaactggat ttacagattc tttaatgaag
    43561 ccatatgttt atattgcaaa tgaactaaat ttgccatgtg tgatttcttg caatcaactt
    43621 gaatctgtaa ctaataaggc tgttatgaaa aattatttta aaaataatgg aatacctaca
    43681 actgattatt gtattattga aagtttgaaa gatttagaaa aaatacaagg attaaatttt
    43741 ccacttgtaa taaaacctgt tgatggttat ggttcaagag gtgtatattt tgtatcaaac
    43801 atagaagaat taatagaaaa atttgaatat tctaaggaag cctcgcaaga tggacaagta
    43861 ataattgagg aattttatga aagtgaggaa atacaaggac tagcttgggt tcataatgga
    43921 gagtcacatg tattttatat tggagataga gagcttgtaa atatacatac aggaagagct
    43981 ggaaaaccag atagattaat ttatccatca aagtattgtt ttcaatatga agaagaaata
    44041 aaatccatat atcaaaatat aacgcaggct tttggcataa aaaatggacc tctttatgta
    44101 caaatgttag tgggagcata tggaataaag gtatctgaag taatgccaag attacctgga
    44161 ggttgtgact atatggctat ttctcaaata acagatttag acataggaag tttatttgca
    44221 aactttagtg tgaataatga agtaaatttt gatgaaataa agaaatataa tatgcatcta
    44281 tcaaaatgtg tatatgcatt accaatatac ataagacctg gcacaataaa aaagataaat
    44341 aatatagata aaatagaaaa cttagattat gtcactcaat ttctattact agtaaaagaa
    44401 ggagatacaa taggattata tgaagatgag agacaggatt gtggaagagt ttatggagta
    44461 gcaaataatg tatttgatgc aaatataaag aagaaatgta ttcatgaaat gatagaaata
    44521 cttgatgaaa ataatgaaaa tatgatagaa aatttttaaa taagggagta tgatagatat
    44581 gaagctaata actcatgaac aaattatgtc attaaacatt tctcagaaac aaggatacga
    44641 gtggataaaa gaatcctttt taacaaaaaa agattgtcaa ttaccaccaa aaataagcat
    44701 ggtagaagaa gggcatgtat tttacaatgt aatgccgtcc ctaaatcata atcataagat
    44761 tggtggaata aaaatggtta caagattgcc agggagaaat ccaagtttaa attcagagat
    44821 atttctatat aatatggaag atgctaaatt aaaggctatt ttagatggca attatattac
    44881 agcttttagg actgctgctg ttgctgcctt ggctatcgat acatttgcta aaaaagattt
    44941 taatactatt gctattatgg gtttaggtgt aactgcttct gctataatga atatgctttc
    45001 atatactctt aaagataaaa atataaatat aaagttactt aaatataaag accaagcaga
    45061 gtcgtttgta aaaaagtatg aaaaaaatga acaatttagt tttgaaatat gtgacacaca
    45121 tgaagaactt attgtagatt cagatgtagt tatttctact gtgacatata cagatgaata
    45181 tttatcagaa tttaaatggt ttaaaaaagg tgctttatta ttacctgtac atgttatggg
    45241 atttggaaat gttgattatc tatttgataa agtatatttg gatgattata atcatttgaa
    45301 acatctagaa aatatagata gatataaata ttcttgtgaa ttttatgatg ttttaagtaa
    45361 acaagctaaa ggaagagaaa atgatgatga gagaataata tcttacaata taggtttgtc
    45421 aatacatgat atattatttg caaataaaat ttacgaattg tgtgaaacac taagctgtga
    45481 agaaatagaa ttaaaagaac caaaagaaaa atattggata tagtttattt cattcatatt
    45541 tacaatagtt tattgtaaat atgaatatga agtaatatat tgttagaaaa ttagcatgaa
    45601 taggatagat aaatttatgg ataaatataa tttaattagg ttcgtatcta ttggaaacga
    45661 atatatagga aatttagttg cattagaatc aaataaagca ataccttttg atataaagag
    45721 agtttattac atatatgatg taccaaacaa tgtaaagaga ggatttcatg cacacaaaaa
    45781 cttggaacaa gtactagttt gcctaaatgg aagtgtgaag ataaaatgtt atgatggtgt
    45841 aaaagagact atatttaatt tacataaaaa tgatgttgga ttatatatag gaacgggagt
    45901 gtggcatgag atgtttgatt ttgatgaaaa aactgtttta atttctatag catctgaaca
    45961 ttataatgaa gaagattata ttagagacta taaagaattt ttaaagtatt taaataatgt
    46021 gtagttatta tacaattagt gatgtatttt cttaattaaa taaatttaag atagccacat
    46081 agagaataga tagattagga tgtgaattta ttgttggtta aatttaataa tttattaaaa
    46141 cagttccaaa ctcataaaga agaatatgaa cagaagatta aggatgtaat ggaaagtgga
    46201 tattatatcc ttggaaatga agtaaagcat tttgaagaag aatttgctaa ctatgtaggt
    46261 agcaaatatt gtgttggttt agccagtggt ttagatgcac tgataattgc ttttagagca
    46321 ttaggaataa gcaaaggtga tgaagtaatc gtgcaatcaa atacatatat tgctagtgtt
    46381 atgggaatca gtataaatgg agcaacacca gtatttgtag aaccaaatga atattataat
    46441 atagattcat ctaagataga agaaaagata aatagcaaaa caaaagctat attagtagtg
    46501 catttatatg gtcaagcaag taatatgaaa gatatacaag aattatgtga taagtataac
    46561 ttgtatttaa ttgaagattg tgctcaatct catggagcta aatatgatgg aaaaatgaca
    46621 ggaacatttg gtgatatagg ttgttttagt ttttatccaa gtaaaaattt gggtgcattt
    46681 ggagatgcag gagctatagt aactagtaat gaggaaatag ctgataaagt gaaaattctt
    46741 agaaactatg gctcagaaaa gcgatattat aataaatttg tcggatataa ttcaagattg
    46801 gacgaaattc aggcaggttt attaagagta aaacttaaat atctaaatga aattgaaatt
    46861 gaaaaatcaa aaatcgtaga tagatatctt aatgaaatta ataatcccaa agtcatactt
    46921 ccaaagatag aaaataattg tactcatgta tggcatttat ttgttttaca agttgaaaaa
    46981 cgagatacat ttatggaata cttaaagaaa agtggtatag agtctataat acattatccg
    47041 ataccaccac atctatctga agcatatgct tatttgggat ataaaaaggg gagttttaat
    47101 atagctgaga actattcaga taaagttgtt agtatacctt tatttattgg tatggaagat
    47161 gaagaagtta gttatataat taaaattata aatgaatatt aaactactca taataatatc
    47221 aaaaataaat tttttatata tcatttattt aaatttcgtt aattgacatt tttaaatatt
    47281 gatatattgt acaaataaaa ttgaaatata tggaaaaata tagaattaag atgagatttg
    47341 tcttatattt ttataaatta aaaatatttt caaagagttt attataaaat tgtaaactat
    47401 agtgtttata atctttgtaa ttattggtaa ttaaatttaa aaaataaaat atttaattat
    47461 acacaaaaaa gatatttaaa aaatttgtta tttattgtat acttaagtta aaactaaata
    47521 ggcaaatcta gagaaatcta gtgacgcaaa gctataggga ctaaggttta tatacataaa
    47581 ctatgtcagc cagttgccaa aaagagtcct aggtgtattg tatacctaag aaaagtctat
    47641 aatgactgcc tttttggcag tcattttgtt atggaaaaat cactttattt cagtagaaaa
    47701 tacacataat aacatatttt accaattata acataaaata aagaaaaatt atctcaaaaa
    47761 gttactattt tacaaaaaaa atgacttctt tatttattta aattaatcgc atttccatta
    47821 cattaataca ataatgtatc aatttagtaa gaaaactaat atttttttaa tgaagtccca
    47881 tgaaaatata aaaaaatttt aatatgtatt taaatatttc ttcgaaaagt tgctcttttt
    47941 tgtaatatag caacttcatt ttttttatta ataaacaaaa tagataaaat atattttgag
    48001 gaggggtgag tgtgaataca tatgacatta taaaaatggg attagatgca actaatctaa
    48061 gaagtcagac aatagcaaat aatatagcaa atataaatac tgaaggatat aaaagacatt
    48121 atataacttt tgaagaaaca ctaaatgatg ctatgcctaa aatagaagaa aaaacagaca
    48181 attctaaagg tttaagagta gatggtaata atgtagacat agaagaagaa aaagtaaatc
    48241 aagcaatggc aacattacaa tataatgctt tgataagttt tgcaaatgga aaaatagcaa
    48301 tgaccaaatc aataataagt gggaggtaat tagaagatga gtgtgttcag tggaatgaga
    48361 atatctgcta gtggattaac agcagaaagt ttgaaaatgg atatcatatc atccaatgta
    48421 gctaatataa atgctacaag aggtccaaat ggagaagcat ataggagaaa agttgtttca
    48481 tttgaagaaa actatgataa taaattaggt atgctaggag taaaagttac atctgttgaa
    48541 gatgataaat cacctcttaa agaagtatat gacccatctc atccagatgc aaagccaaat
    48601 ggatatgtag aatatccaaa tgtaaatata ttggtagaaa tgacagattt aataacagct
    48661 tcacgagcat atgattctaa cgtagataca ttgaatgctc agaagtctat gatatcaaaa
    48721 gctttggaaa taggaaagta gggataaatt atgccaatta cacaaattaa caatttaatg
    48781 caaggtgcaa agttagataa tttgattgga gaagcaaagc cattaactct taataataaa
    48841 gaagaaaaaa agaattttga agatgtaata atagatacta tagataaagt taattttcaa
    48901 caagtaacag cagatgatat gaaagaaaaa tttataaaag gcgaagatgt ttctatgcat
    48961 gaagttatgt taataggtca agaagcacaa ctatctatgc aatatttaat agaagttaga
    49021 aataagattc atgatgcata tcaagaaatg aataaggtgc aaatttagcc ttttgaacag
    49081 gagtaataat caatgataac cagttttaaa aataagatta aggagcaagt tgctaaatct
    49141 aggacaaaga taagttcttt aaaaaaggga actaaaatag cattaggtat aggggttatt
    49201 gctatatgtt tagcgctagt atttacagca atatctgcga gcaaaaataa gtatgcagtc
    49261 ttattttcag aactagatgc tcaagatgct gcagatatat cagcagagct agagtctaaa
    49321 aagatagata ctaaggtaaa aggaagtacg atttatgtac ctagaacaga agttgataag
    49381 ttaaggctgg agttagcgcc aagtcttaca ggtggttcta aaggatttgc actaatggat
    49441 gatagttcat caatagggct tactgatgaa gaatttcaga ttaagaaaca aagaatgata
    49501 caaggtgaaa tagaaaaaac aataaagagt tttccacaag tggaagacac tagagtacat
    49561 ataacatttg gagagtcatc agtatttgag aaggaggctg ttccagggag tgcagcagtt
    49621 tatttgatgc taaaaccagg gacgacttta gaaaaaaacc aaataaagtc tgttatggca
    49681 cttatatcag gaagcgttac aaatatacca gagaaaaatg ttcaggttat tgataacaaa
    49741 atgaatttat tatctgaagg tattttggag gatgaaaatg ttgatgaaaa taatcaacca
    49801 ataaatagtg gcattagtgt tgataaaaat aaggcatctg aacaagcatt gaataaacaa
    49861 ctagaaaagt ctattttaga aatgctagaa ccgatatttg gtaagggaaa ggtgaaagct
    49921 acagtaaatg ctgatttaag ttttgataca gctgaaaaaa ctgagataaa aattgaccct
    49981 gataaagttg caataaagga gacaaggtcg aaaaattcat ctaaatctgc tgcaaataat
    50041 gttcaaggtg tagatgctaa catgaataac caaggaaata acaatggtac taatacagaa
    50101 gatagtttag atgagagttt tgagtatgaa acaggtaaga ttgaaactca cactatagtt
    50161 gcgcctggag aacttaatag attgacagct tctgttgcaa tagatggaaa aatagctaaa
    50221 ggtgttcaag ctgatgtaga ggatattgtt aataatgcta taggtatgga tggagcgagg
    50281 ggagatactc ttagcgttgt ttcaatggta tttgacccag aaggtaagaa agaggctaaa
    50341 caagagctgg aagagattaa aaaagaagga tttaaaaaga acataataaa agcagttatt
    50401 ggagtagtag cagtaatagc agttggagct attggatact taatatataa gaaaagaagt
    50461 gaacgagaag atatggatta tgaagatgaa gattatattt ctaaatctga ttctgttgat
    50521 aggaaggata atcctctatt aggagatgat ccagaactga cattagagga agctgttaaa
    50581 atgtatgcag aagaaaagcc agaccaagta acagagataa taaagacttg gttaaatgag
    50641 taagggggat agaaagtgtc cacggaaatt acaaatgtta atgcgtttga cttaagtgat
    50701 ataaatgaaa gtgataagaa tgagaaggta gaaggtgagg gtttaaaaaa agctgctgta
    50761 ttattaatga cattaggccc aaatgtgtct agtgatataa taaaaagctt gcctgataaa
    50821 caagttcaaa aaataggttt ggaaattgca aatatttctt caatagcttc aaaagaaaga
    50881 agagaaatct taaaagagtt tgtagaaata aatagggcaa aagattatgt tatagaaggt
    50941 gggcttgaat atgcaagaga gttattaagt aatgctttag gaaatgttaa agcaaacaaa
    51001 ttacttgaag gtatatcaat aaatacaagt acaaagcctt ttaaacatat tataaaacta
    51061 gatgtaaaga agatattaga aatacttagg aatgaaagtg cacaaactat agccgtttta
    51121 cttgcacata tggaaccaga aaatggagca gaagttttat catacttaga ttttgattta
    51181 caaaatgaag tagctatgag aataagctca atgggttcaa tatctccaga agtaataaag
    51241 gtaattgaaa gttcattaga agataaatta cattcaataa gtggtgatga ttttaatgat
    51301 tatggagggg tgtctacctt agttcaaata ttgattaatt ctgatagaaa aacagaaaag
    51361 aatattttgg gaactattga agaacaaaac ccggatttag cagctcaaat taaatctcat
    51421 atatttgtct ttgaagatat tgtcaagtta gatgatataa gcatacaaaa agtgttaaaa
    51481 gaagtgacta tgaaagattt agtatatgcc ttaaaaggtg tagatgatga gatttcagat
    51541 gctatatata gaaatcaatc ttctagagca gcagatgcac ttaaagaaga aatggaaatg
    51601 gttggtgtta taaaggttac acaagttgag gcttctcaac aaaagatagc taatatcgta
    51661 agaaaacttg aaagagaagg tgccataact attgtaagga attttggtgg tgactttgtt
    51721 gaataataag attattaaaa gtaaaaaagc attatataaa ggagtgctag atttaaccat
    51781 aatagataaa gttagagtgg gagaatcaaa tgtaaataaa gaaaatgatt gtagatttag
    51841 ggatgaggta ataaaagaag ctatagaatc tgctgagata aaaaagaatg agatattaga
    51901 agaagcaaaa ataaatgcac aaaatataga aaagcaagca tatgaaaaag ggtatagtca
    51961 aggtcaaaaa aatggatatg aggatggata taaagagtca tatgatgaat atacccaaaa
    52021 agctaaagat gaagcagatt ttataaaaaa tcaggcaaat ttaatcttat tacaagctaa
    52081 tgagaagatg actgagtaca taaaagaaaa aaataaagag attgtaagac ttgctattaa
    52141 tatggccagt tctgttttaa aaaagcattt cgaagatgaa gaatctatga gtgatctgtt
    52201 aaagcaaatt attcaagatt atgaaggaag tagttcattt atagtaagat gtaattcttt
    52261 ctataaagat aatatagaga aagagtttga attattcaaa gaggaaacat cactaaaatc
    52321 aagtgtattt gttattgcag atgatagtat agataaaggc aatgctatta tccaaaagga
    52381 aaatggaaga ataatagttg gtattgattg tgctatggaa aaactaaaag aagaattgct
    52441 tggtgaataa agtatgtata aaactgatat atctatagat tttgacaaaa taaataagaa
    52501 aatagaaaat ttagaactca ctatatcaga aggtagagta aagaagataa taggacttac
    52561 tgtagaagtt gaaggaataa aagcttttgt tggggagtta tgcgttatat acaaccaagt
    52621 taataaacca gtgaattgtg aagtagtagg ttttaaagat aaagaagtca tattaatggc
    52681 gttgggagaa ttaacattga tagcacctgg ttgtaaagtt atttctaagg ggataccttt
    52741 aagtgttatg tgtagtgata atttactagg taaagtactt gatggtcttg gaaatcctat
    52801 agacaactca gatgctgttt taggagatag atacaacctg aacaatgaac ctcctgatcc
    52861 aatgaagaga aaaaagatac gaaatataat ggaaacaggt gtaagagcaa tagatgcatt
    52921 tactacttgt ggtgaaggac agagaatcgg catatttgca ggaagtggag taggtaagag
    52981 tacgactcta ggtatgattg ctaggaatgc aaaagcagat gtaaatgtaa ttgctcttat
    53041 tggagaaaga ggaagagaag tactagattt tattgataaa gatttaggtg aagagggaat
    53101 gaaaaaatct gttgttgtgt gtgcaacatc agataaagcc cctctagtta ggttaaaagg
    53161 tgctcttact gctactgcaa tagcagaata ttttagagac caaggcaaaa aagtaatact
    53221 tatgatggat tcagtaacta gatttgctat ggcacaaaga gaagttggtg tagcaatagg
    53281 agagccacca gctcaaaaag gatatacacc atctgtattt gcaatgttgc caaaacttat
    53341 ggagagaaca gggacatcag ataaaggttc tataactgca ttttatacag tattagttga
    53401 tggagatgac tttaatgagc caatagcaga tacaacaaga gggatacttg atggtcatat
    53461 agttttatct agagacttgg caaataagaa tcactatcct tctatagatg tattaaacag
    53521 tttaagtagg cttatgaatg aaattgcttc aaaagaagac ataaaaatag cgtcttttgc
    53581 aagagacatg cttgctgagt atagagaagc agaagatttg ataaatatag gtgcatatgc
    53641 ttcaggtaca aataaaaaaa tagatgaagc aatctattat catgagcata ttattaattt
    53701 tttaaaacaa gggataaatg aaaagagttc ttttaatgaa actataagta gtttgagaag
    53761 agtttttgaa taaacaatta aaaaaatatt tgaataggtt gtgatggaat tggataaaaa
    53821 ctttaagttt agattacaga aagttttaga cttaaaagtg aaagatgaag aagagataaa
    53881 aatggaattt gctaagattc aacaaaaaaa aatagatata gagactaatt tagaaaactt
    53941 agaaagtaat tatagcaaat attctataag taaaaataac gatagtattc aaaatcaaaa
    54001 aataactatt aactatttac tagctttaaa caattctata atggatttat cagaagagtt
    54061 ggataagtca acaaatgaac ttgaaaaagc tagaaagcag cttataagca aacagataga
    54121 gagaaaatca ttagaaaaat taaaagaaaa aaagtatgga cagtattata aagaagaaaa
    54181 tttaaaagaa caaaacacta atgatgagtt tgcaagtatg agttatttaa ggaatagaca
    54241 agttctataa gaatagtagg aagtgaggat attattgtat gaagatacaa gcagattctt
    54301 ataatattat taaagatatt ggggatagaa aaagttcatc taagaacaaa aatataaaaa
    54361 ataataaatt tgaagataat ctatataagg caacagacca taaaaaagtt aaagatagaa
    54421 gggaagtaag taagcaaaat attagctcag ataaaccgga aaatagtgat aatgagtgtc
    54481 atttagatga agataaaagt aatcacttag aagatgaaaa tacatatgaa aaagattgta
    54541 gtaagaataa tgaagctttg cagcaattac tgaatctttt aaaggataat tataaaaaag
    54601 ataaagatat aaacactata ttgaataata tagaaaaact aagtatatca gatgaattaa
    54661 aacaagaact taagcttaat aaaaatatat taaataagat tgcaaatcaa aattcagagc
    54721 taaataaagc taatataaat aactctaatg atatagaaaa tttagacata gttaaattaa
    54781 gagaactttt ggaagataat gctaataaag atattgaagt aattactaaa actacagaaa
    54841 atgataccaa aaatatagat ttgtatagtt ttgatagcaa tagaatggat aatcttaact
    54901 caaataaaca gaaagatgat agctctgata ttttggaaaa actagcaggg gtaaatggaa
    54961 ataagagtgg gaattttgga caagtaataa ataaaaatgt tgatatgaat aaaattaaaa
    55021 atgataatgt caatttaaaa cagatagaat caaatgtaat ggatgactct ataaaagcta
    55081 ttaagcatat gaaaacaaat gatatacaag aattgacaat taaattaaga ccaaaagaat
    55141 taggagatat gaatatacaa ttgttaaaag atggtgaaag tatgagagct gttgtgactg
    55201 ttttcaataa agatgtcttt gactctataa ataaaaacat agcagattta aagcaacatc
    55261 ttgaacttac taatgtaaat ataaaagatg tatcagtgca aatgcacagc gataatacaa
    55321 atacatctga tacctttgat aaagcatttg aacaacagaa tagacaaaat aaccaagaaa
    55381 acatgagtaa gaagaataca aatgataagc ataataatgt agtcatagaa gatgacatta
    55441 aagaaaatac tattgatgat gatagagtag atttactagc ttagtaaggg ggaagtattg
    55501 catgtacgga atagcaacgg ctttggcagg aactcaggga aactataggt caaataactt
    55561 aagccaactt gaaagaaata ttaatgatat tgccaataaa caagttagaa gcaaaggaaa
    55621 tcagacagta acagacaatg ggactccaat tataggacaa ggtgatgatg ctgataaaga
    55681 cttgtttatg aagatacttg tggcacagat gggtaatcaa gacccaatga atccgcaaga
    55741 cccaacagaa tatgtgtcac aattagcaca gtttgcaact ttagaaaaga tgtcagctat
    55801 gaatgagaag ctagatgtac ttttagcctt aagtaattcc actctaataa actctgcttt
    55861 aagtatggca acatcattaa ttggtaaaga agtagaagta tctggggaag agaaagaaga
    55921 tgaaaacatt gtaggagtag taaagtccac atatataaaa gatggggaag tacacttaga
    55981 attagaagta gatggaagtg acaaaactgt aggtgttaaa tatgaaaaat tacttaaaat
    56041 aggagaggta gatgaaaatt caggagaaga aaatgattct tcagaacacg aatctccaga
    56101 agaagcataa tattaaatga gaaaagaggt aaattcatga taaaagcaat gtattcaggt
    56161 gtaagtggaa tgaaagcaaa tcaaacaaaa ttagatgtaa taggtaacaa tgtagccaac
    56221 gctggaacta cttcttttaa gaaaagttca gctagaataa cagattcatt ttatcaaact
    56281 gtactatatg caagtgctcc aacagctgca ttaggaggaa caaacttagg acaagtaggt
    56341 gtaggtagta agatatcaag tataaataaa gatatggtac aaggaaatgt acaaccaact
    56401 aatagaccat ctgatttaat gatagatgga gatggatatc ttccagtagt aagacaagga
    56461 acagttatgt atacgagaga tggttctttt aatttagata caggatttaa agcagctgat
    56521 ggtgctttga agaatattaa aggtggaaga cttgtaaatg gtgatggata tatgttacaa
    56581 ggtatgattt atgatgggga atataaagct gatactggag aatttgttaa aaagggtgat
    56641 gctaaaggaa aagagcctat tgtaatacca cttcaaagta taagtcctaa ggatggaaca
    56701 gttcaaaatg tactagagta taatatatca aaggatggaa cagtagaatt tttattgagt
    56761 gatggtcaaa gaactcaatt tgtctatgat atacctgatg gtgctaaggt aggagataca
    56821 cctgctggaa tagataaatt aaaaggtaca atacaaaaag tgcaaacata tgcattccaa
    56881 aatccagcag gactagatgc agaaggagga aacttgttta aaccatcagc aaactcagga
    56941 gacccacaaa tagcaggagc tacaggcaca ataatacaag gggcaataga agcttccaat
    57001 gtagatatag cagaagaatt tacagaaatg ataatagcaa gtaggtcttt ccaagcaaac
    57061 agtaaaataa tatcgacatc agacgagata cttcaagaaa taataaatct taagagatag
    57121 taggtacata ttatgataag agtaacggat ttaaacggaa gaaaatacat attaaattca
    57181 gaccttatag tgaggattga ttctgtacca gaaagtagga ttctccttac aacaggagaa
    57241 aaaaaccttg taaaagagtc ggtagatgag atagtagata aagtaataaa gtataaaaga
    57301 aaaataaatg taggttatat taggagcgaa aaataatgaa aaaaacagat tcactgacat
    57361 ttattggact aatagtatct acagtattag ttttagttgg tgccgcaaaa ggaagtagtt
    57421 cagggttaaa gaattttttt gatgtttcat caatattaat cacagtgctt ggttcatttg
    57481 gagctctaat gattacattt actatagatg atataaaact tataaaaaat gcattacaat
    57541 actcatttaa gacaatgagt gtatcaaagt tagatttact agaacaattt aaaacacttt
    57601 ctaaaaaagc tagaaaagaa ggtcttttat caatagagag tgatgtaatg ggaatagaag
    57661 atccatttat gaagaaaggg ttagagctgt gtattgatgg attggaaatc aatgagataa
    57721 ggtccatctt agaactagag atagattctg ttgaagatac aaataacaga tactctaaac
    57781 tatttaaaac ttggggaacc tttgcacctg cttttgggat gttgggaaca ctaataggtt
    57841 taatacaaat gttagctgac cttacatctc cagatttaat agcatctggc atgggaaagg
    57901 cattaattac aacgttttat ggttctttac ttgccaatat cgctttgaac ccaattgcat
    57961 ataatataga tgagaagact gaaaaagaaa tttatgtaaa ggaaatgatg ttggaaggta
    58021 taataagcat acaatctggg gagagcagta tagtagttga ggaacgttta gccacatacc
    58081 tttcaaacaa tgagaagtta gaaattatga aatccaataa aaatacagaa agagcaatga
    58141 gcaatggcgc gtaaaaaaaa taagaaaaag gatgagataa atccagatgc atggctggct
    58201 acttatgcag atactataac actgattctt acatttttcg tattattgta tgcaacatca
    58261 gttgtagata tggaaaaatt taaaaacata gcagatgcgt taaaaggtca gttttctggg
    58321 acaagtatat ttagtacggg ttcaagtaca agtgagaaat ctccaataga cagtgtttta
    58381 gtggataaaa atgataaatc aaatttagaa caggatttaa aagataaagt taataattct
    58441 aacttacaaa atagtgtaac agtcaaagat gatagtagag ggattttact agagttagat
    58501 gattcaattt tatttgactc tgggatttct gagttaaaag tagatagtaa agctactctt
    58561 aataaagtat atgacatgat aaagatgatg aaaaataaga tagttataga aggccatact
    58621 gataatgtac ctgtaaaatc aagtacacat gaatccaatt gggatttatc ttctagtaga
    58681 gcagtaagtg ttgtaagata ctttgtagaa gaaaagggca tggaccctag actattttcg
    58741 gcaacaggat gtggagagta tcaacctttg gtttcaaatg aaacagcaaa gggaagggct
    58801 gagaatagaa gagttaatat acttataact attgactagg aggaagaggt ttgttcaaaa
    58861 ataaaaaaat tattataatt attttgatac tgattatttt ctcagcggga gcaggttttt
    58921 ttatattagg agaaggtgga aataaacaag ttgacaagat tgcagatttg tttattccaa
    58981 caggaaaagg taaagatgaa gtaaagaccg aaaatcttga cttagaagag atggtattaa
    59041 agctagctga tgaaggtgta agatatttaa aagtatcaat aactgtatct tatgattctt
    59101 catataaaga tatagaaaaa aatacgcctt taattaggga taatattata aattgtttta
    59161 tggcaaaaag ggcagatgat tttactgctg ataatttaaa gaacataaaa gaagaaataa
    59221 aaaatacatt aaatatacaa ctaggtgaaa atgtaattca aaatatatat ttcacaaata
    59281 tagtagtgca ataaaaggat ggtaagacat gatactttat ttactaaaaa tattaatatg
    59341 tatcccaata attttaatat tgatagtctt atctttaaaa attagccaag gaactttatt
    59401 aaaaaaatat aatgataaat atgtaaaaat actagatatt gtaaatataa gtaaaaacaa
    59461 tagcataata attttaaaaa taggtgaaga aggatgcatt atggcatctt cttcttctag
    59521 catgagtaaa ataaaagatt tgaccaaaga agaaatatta aaaatagaaa acgacattaa
    59581 agaaagaaat tttaaaattc aagattttaa aatggaaaga attaaaaaga aatatgattt
    59641 cagtagatat attggaaaat ttacaaaaaa ggaagataag taaatggaac tattatcaaa
    59701 attacctttg gctgatgtac catatacaag ttcaatgcaa ttgtttttat ttctaactgc
    59761 attaatgttt ttaccatttg taatgttcat gatgacaagc tttgtcagaa tagttataag
    59821 tttatcattt ttgaaatcag cattaggagc acagcaagca attccaagtc aaattttggt
    59881 aggacttgca atagtattga caatatttat aatgagacca gtattaaatg agataaacga
    59941 aaaggcatta caaccatata tgaaagaaga agttactatg gaagaagcta tgaaggaagc
    60001 agaaggacct attaaagagt ttttattaac acaaaccaga cagacagatt tagatttatt
    60061 tgtagaacag gctggtttaa aagaaaagaa attaactcgt gaaaatatac cactatctgt
    60121 tgtagttcca gcatttgcta taagcgaact aaaaactgct tttcaaatag gttttttaat
    60181 atatatacca tttttgataa tagaccttgt tgtggcaagt gttttgatgt ctatgggtat
    60241 gtttatgttg cctccagtca tgatatcatt accatttaag ttattattat ttgtaatggt
    60301 ggatggatgg aacttgatag taaaaacatt gatattggga tttggatagg agaaaaatag
    60361 tatgagtgaa tttatgataa tgagtgttct taaaaatggc atgtttacag gagctatgat
    60421 tgcagctcca gtactcattg tttctcttgt agttgggctt ttaataagtg tgtttcaagc
    60481 tacaactcaa atccaggagc aaactttgac ttttgtacca aaactaatag ctattctttt
    60541 agtagtagct attggtggaa gctggatgtt acatactctt attagtttta cttctgagat
    60601 attcaatatg atatctctta taactaaata agtaggatac atatgatttt tgtatttatt
    60661 agaatagtag cattctttgg aacactaaga atactatttc cagctggtac acctgcttta
    60721 tttaagtcac tctttgcaat cattatatca atattgattt caagtactat gcaaattgaa
    60781 tatgcaacaa atatagacaa cattgtattg tttaccttat atggtgtaaa tgagaccata
    60841 actgggatta tgcttggata tataaccaac ctatgttttt atagtatcag aatggcgggt
    60901 tctatgatgg accaacagat gggattatca atgattaata tgtttgaccc aaattcaatg
    60961 actcagacaa ctttaattga taatcttatg aactggacag cacttatgat attttttagc
    61021 atggatggtc atcatgtttt aattagaggt ataaggtata gttttgagtt aattccaata
    61081 ggaaaaccat ttgtagataa taacatagat tatataataa acatatttgt gcagtgcttt
    61141 ttaactggat tcaaaatagc aatacctatt gtactttgtc tgcttatggc agattttatt
    61201 ttagggctta tatcaagaag tgtacctcaa ttaaatgtaa tgatagttgg tatgccatta
    61261 aaaatattgg ttggtattgc attatttatc atatcaatac ctttaattgt caatcaaata
    61321 agtcatttat taagtcaaat accaaagatg tatgagggaa cttttgcact agctcctatg
    61381 ttttttatgg gttcagcaga taaaacagaa gaagctactc caaagaaaaa gggagaacaa
    61441 agaaagaaag gtaatatagc aaagagtaga gaattacccg ttgcaatgac tctacttgca
    61501 ttcaccttat tagtacctac attattttca tatgtagtag atacacttaa atcttcgctt
    61561 aattattttt tgagtctaga tttttatatg aacataaatt attcaaacct agagaaatta
    61621 gttatagcag gattaatgga tttttttaag atatttttac caatagctat tcccttttta
    61681 gttttaggca taatagcaaa cctatttcag gtgggaatac tgtttactgg tgaaacttta
    61741 aaaccaaatt tatcaaaatt aaatccaatt agtggattca aaaacatgtt ttctatgaga
    61801 agtttgtcaa ccttaataaa ggatacagcg attatatcta ttttggctta cataggatat
    61861 acattcttcc aagataatta tttagatata ttaaagctag gtaacatata cctaccaact
    61921 ttaatgtaca cagttaaaga cttagtatat tcaatattga gtaagatttg tgtagctatg
    61981 atagctatag cagttgcaga ttatgtttat caaagataca gtcataaaaa gcaactgaga
    62041 atgacaaaac aagaagttaa agatgaatat aaaaactcag aaggagaccc agaagtaaaa
    62101 gctaagataa aacaaaaaca aagacaaatt tcgtctcaaa ggacaatgca agcagtacca
    62161 agtgctactg taatagtaac caatccaacc cacttatcta tagcagtgag atatgaaaaa
    62221 gggaaagacc aagctccagt agtggtggca aaaggtgcag attatctagc ttttaaaata
    62281 agggaaattg caaagggaaa taacatccct ataatagaaa acaaacctat tgctaggttg
    62341 ttatataagc aagtagaaat agaccaagaa attccagagg acatgtatca agcttttgca
    62401 gagatattag tggcagtata taaaatcaaa aatagataca aagtccccaa aaggtaggat
    62461 aagtaatgaa taagtttaat ttaaaggaaa atatggatgt aatagtggca tttggtgttg
    62521 tagggattgt tcttatgatg atagtgccat tacctacatt tatattagat attttactgg
    62581 caattaacat aagtttatct gtgctaattt tactaatgac attatttaca acaaatgtac
    62641 ttgatttatc tatatttcca acagtgttac ttgtgacaac actatttaga ttgggattaa
    62701 atctttcatc aactagattg attttaacac agggatatgc aggtgaagtt atagaggcat
    62761 ttggaagttt tgttgtaggt ggaaattacg tagtaggaat aattatattc ttaattatat
    62821 taattgttca atttgttgtt ataaccaatg gttctggaag agtatctgaa gtaacagcta
    62881 gatttacgtt agatgccatg ccaggtaagc agatgagtat agatgcagat ttaaatgcag
    62941 gagttataga tgacaaaact gctagaaaaa gaagaaaaga gcttcaacaa gaagcagatt
    63001 tttatggttc tatggatgga gcaaataagt ttgtaaaggg agatgccata gcaggtctta
    63061 tagtaacagc aataaacata ataggtggaa ttgtaatagg agctgtaatg ctgaatatga
    63121 ctcttatggg tgcagcacag acatatgtaa gacttactat aggggatggt cttgtaagtc
    63181 agatacctgc tctattaata tctacatcag caggtataat cgtaacaaga gcttctactg
    63241 atgaaaactt tggtgactta gtaggtaaac agttaacggc aataccaaaa gcagtaatga
    63301 tgactggttg tgttctaatc gtacttggta tgatgcctgg attacctaaa ccagcatttt
    63361 tttcactagg tataggagct atagcagcag gttacttttt aggaagagaa aagaaagata
    63421 ctttagaaga cttggagttt gaaaaacctg atatggtaaa cccagataaa aatgaagtag
    63481 aagatgtaac aaatttaata aatgtagaat caatagaagt agaaattgga tatggtttaa
    63541 tatccttagc tgatgaatca gcaggaggag atttacttca gagaatagca tcaataagaa
    63601 gacaatgtgc aatagatatg ggtatagtcg tacaacccat aagaataaga gataacttac
    63661 agttaaatcc aaaccaatac aatataaaaa taaaaggaaa tgtagttggt gggtatgaga
    63721 taatgcctaa tatggtttta tgtatggacc ctatgaatca aggatttagt atatttggaa
    63781 taaagacaat tgaacctact tttggaatag aggcactttg gatagaaagt gacaaggtag
    63841 aagatgcaga gttaaagggt tatacagttg tagattcatc cacaatactt ataactcact
    63901 tactagatat aataaaatca aatgcacacg aattactggg aagacaagaa gttaagacta
    63961 ttatagatgc agcaagagaa aattatagtg ctgtagtaga tgaattgata ccagatttga
    64021 tgacacttgg tgaaattcaa aaagtactta aaaatctgtt aagagaaaaa gtaaatataa
    64081 aggatagagt tacaatactt gaaacgcttg cagaccagtc tagaaataca aaagatatag
    64141 agcttcttac tgaatatgta agaatagcct tggctagaag tatttgtaat aatttagttg
    64201 atgatgataa gacaattgta gtggctacat tgtctccaga aactgaagag ttggtatcta
    64261 ataatttaca gaggtctgta aatggaactt atccagcagt tgacccagaa aatacaaata
    64321 aaatatttga aagtatacaa gaagtaatga gcaatgtata tttcaatcat aatataccag
    64381 taatagtagt atcaccaaag ataagagctc catttagaaa attagttgaa attgtatatc
    64441 ctaatttgac tgtattatca ttaaatgaaa tacctaacga tattaaaatc aaagcagaag
    64501 gtgtggtgag catatatgat gacgaaaaag tatacagcta acacaattca ggatgctatg
    64561 aatctagcca aaatggaatt gggtgacaat attacattaa tagataaaaa agaggtaaga
    64621 aagtctggaa tacaaggtat cttttcaaaa aaagatattg aactaactat tggatgggaa
    64681 aagagagaaa atgtagaaca aaaagattta aaacgagaga tagaacaatt aaagtcaatt
    64741 attaacaata tggggtttga taataagaat gataatgata tagataaaat atgtaaaaat
    64801 ctactaagtt tagaattgaa tgaagaaatt gtagaatcta taagaattga tttgcaagaa
    64861 atgaagttca atggaatcga tacaagtaaa aatttagtag aaattttaaa gaaaaagatt
    64921 aaaatagaaa atcaagtaat aaatggtaaa attgctctag tcggaccacc aggagtaggt
    64981 aaaacgacta caatagcaaa gttagccgca aaattagttt ttgaagaaaa taaaaaagta
    65041 ggagtaataa ctatagatac atacaggatt ggtgctgtag aacagttgaa gatatatact
    65101 gatataatga atattccctt taaaggggta ataagtcctg atgaaatgga attggcactt
    65161 gacgagatga aagattgtga tgttgtatta atagatacaa caggtagagg ctacaaaaac
    65221 tctatgcaaa tactagaaat caaaaatctt atagataaag ctgaaactga taatatacat
    65281 ttagttttga attgtacaac aagagaaagt gatacaaaag caattataga ttcatataga
    65341 aatgtgaatt ttaaaagctt aataattaca aagctagatg aaacaataac atatggctca
    65401 atatttaaca taatgaatta tgcgcaaaaa ccaatatcat atattacaac aggacaaaat
    65461 gttcctgatg atattataaa acctaatgaa gataagatta taaggttact attaggagtt
    65521 gaaagtatat gatagaccaa gctcaaattt tgagaaaaat agcaatggaa aaaagaggac
    65581 ttgatgagtt tatagtagag aatgagaatg tacctaagat aattacaata gcttctggta
    65641 aaggcggtgt tggaaagagc aatctcgcta caaatttgtc tatatgcttg accaaactta
    65701 ataaaaaagt tcttatatta gatgcagaca taggaatgtc taatatagat ataataatgg
    65761 gggtaaatgt aaaagggact ataattgatg taattaatgg cgaaaaaaat atagaagata
    65821 taatttcaca gactaagtat ggtgtaaata taatatctgg aggttctgcc cttaatcata
    65881 tagaagactt tacagaagct caaagaaata agtttataca tagcatagaa caaattcacg
    65941 atgtggattt tataataatt gatacaggag ctggtatgag caaaagccta ttgtcattta
    66001 tatactgtag tactgaattt ttcttaataa caactccaga accgacatca ttgactgacg
    66061 catatagttt attaaaagct ataagtaatt ttggcataaa gagaagtgca aatataataa
    66121 tcaatagggt aattgattta gaagaagcaa aatctacata caaaagaata aaaatggttg
    66181 tggacaaatt tctaaacctt aatctagaat tgtatggata tataatagat gacaaaaaag
    66241 taagtttatg tgtaaaaaaa cagataccat tcattttaga atatcctaca agtattgcat
    66301 caaaatgtat tatagccata gcaaagagaa tggtaagtca gtcaagagaa gatattgttg
    66361 ataataaaag ttttctaaga aagatgttta gtatatttaa aagctaagga ggcgtagtta
    66421 atgaatagag aagaattaat aaaagagaat atgcctcttg taaagagtat agcaagaaaa
    66481 ttttttatac cagggaaagg ttttgaatat caagacttag taaatagtgg agtcattgga
    66541 ttgattgatg caataaataa atttgatgct gaaaaagggg caaagttttc tagttactct
    66601 tatataaaaa taaaatctgc tatattagat gaaattagaa atcaaagtcc aatttctaaa
    66661 cataatctaa ctaaagtaaa taagtataat agagtggtag aaaagttgca atctaaatta
    66721 ttaagagagc caacttcata tgaaattgca aaagaattaa aggtttcaga aaaagaactt
    66781 catgatatcg aaagtaatat agatatgtta aatattgtat cattaaacta tgtaatcttt
    66841 gaagatacaa atgaaactgt acaagatgta ataagtgata gagaagagga agctccagaa
    66901 aatataatag aagaagaaga aaagttagag attctatcca aagcaattag taatttaaat
    66961 gaaagagaaa aattaatact ttcactgtac tattatgaag atttaaatct aaaggagata
    67021 gggaaagtgc taggtgtttc agaatcaaga gtttcacaac tccacagaaa atcaataaga
    67081 aacttaagaa acaagataaa agaacttaaa tattctatat agatggtgat tgataagatg
    67141 atacaaatta tattaatagt agtgtctatt ttaataatag taactatagt tataaattta
    67201 cataaggaat caaaaaataa agataacaga tactttgata aaatatttga gcaagaatat
    67261 gaagcaaatg atagattaat aattgcagaa aaaagaagat tctttttaga caaagtactt
    67321 gcagaaaaaa gaattaatag tcatataaaa gtttatgaaa attataacct aataaaggct
    67381 aatgaagaaa gaaaggaaaa catatttata gaatcaaaaa aggaagtaag acaagaaaat
    67441 gagttatctc ttaaagtgaa acatcttata agttcaggtt atgatgatgt ggaaatatgt
    67501 aagatgctag atattggaaa gggggaactg ttattaataa ggagttgtta caaaatataa
    67561 ggatattatt atgtgataaa aaagtattct taggaatagg tattggtata ttaatatcaa
    67621 ctttatgtat aatgcttttt agtaataatg atatgagtaa ggcagagata gaaaaaaagg
    67681 ccagagcgtt aggcatgaaa tatacaagtg agatgaaagt tttagaatag atgatattgt
    67741 ttagacattt acaaaaaagg aggtcataat gtgataagag gattatatac agcagtttct
    67801 gctatgataa ctaatcaaca aaagcaaaat gttgttgtca ataacctagc taatatggat
    67861 acaaatggat ataaaagtaa acaacttttg actaaaagtt ttgatgaatt aaagttggag
    67921 ggttacaata actacgcaaa tggaactaaa caaaagcaga ttataggcga tataagtcca
    67981 ggtatttcta tggatgaaac tatcacaaat tttaatcaag gacctataaa aactactgat
    68041 aataaaatgg atgtagctat tcaaggtaag ggattttttc tagttagtga tgcagctgga
    68101 aatcaatttt acactagaaa tgggaacttc agaacagaca atcaaggtga ccttataaca
    68161 agtgaagggt attatgtact tgggacgaat actgctactg gtgctgtagg tcatataaat
    68221 gtaggaaatc aaaaatttga agtggcaaaa gataatacaa tatcactaga cggaaatgct
    68281 atgtataaat ttaatattgt agattttaat aactacaata acttaaaaaa agaaggagat
    68341 aacttatatt ctggaggagg agctatgaaa gtaaataatg cacttacaat acaaagtgcg
    68401 atagagtcct ctaatgtaga tatggtatct gaaattaata atatgatgac aatatcaaga
    68461 gaatatgagg caaatcaaaa gataattcag gctatggatt ctaaattagc aaaaatagca
    68521 agtgagattg gttcagtaag ataggtaata ggaggtgaat ttttatgtac acaatgtttt
    68581 atactagtaa aacagcttta tcagcaaatc aaagtaaact agatataata tctaacaata
    68641 tagcaaattc tgattcaaca ggatataaaa aaataaatat ggaatattct gatttagtgg
    68701 atgaagtact aaatagacca tcatatccta caaatggcaa tgatatatcg actggaacag
    68761 gagctaaggc aacagctccc atgagaaatt atgaacaagg tgcattggct cctacagata
    68821 gtaagagtaa tttggcaata gatggagaag gattctttag agtgataaga aaagatggta
    68881 catatgcata tacaagaaat ggtggattta atgtagatgc tttaggtaag attgtagatg
    68941 ataatggaaa tatattagat gtccaatttg atgcaggata taactataat aatacaaata
    69001 tagatagtac aaacctgaca gtttcaagaa atggagagct attcgtagat aataaaaaaa
    69061 taggaaaaat caacttatat caacctatag gaactcaaaa ttttatatct gaaggagata
    69121 gtttattcgt cgcaactgat gcagcacaga ttaaacaagt tgagaaagtc gatatagttc
    69181 aaggctatag agagaggtca aatgtttctt tacaagaaga atttgttgac ttaatagcca
    69241 ctcaaagagc atttcaaatg aactcaaagg gaataaagac agcagatgaa atgtggcaaa
    69301 tagcgaataa tttaagagct aaataattat gtaaggtgag gaatattcat gaatgatatg
    69361 aaagagtacg attttggcaa acctcagagt tattcaagag aaaatttaac ttgtttaaat
    69421 tttttattag ctgaattttg taaaaaatat aaaaactata taatttatga acttaagtgt
    69481 aattctagta tggttgttga tagtatagac caagtaaatt atcagacttt tttagataga
    69541 gtaacttctt catgcgtagt agtacaaaat gcaatggaac ctgttatgaa aaacttttct
    69601 tttagaatag atagaagtgt agctgatatg tggattgata taacttctgg aggaactgga
    69661 gttgtaaagg ataatgatag agaacttaca gaacttgata aaaaagtgct tttacacctt
    69721 atggatgatt tagtaagaaa tatgcactta tttgagggtt ttgaaaatat acaagtattg
    69781 gatacacata cacatattaa tttgccacaa ttatgttctc caactgcacc agtatgcgtt
    69841 gtagatttaa aagtgctaaa tgataatgag tatattggaa gtgtttctct ttgctttcca
    69901 tacaatggtt tagaggctct gttagaaagt atatctgtta tagaattttt tgataatgat
    69961 gtaggagatg attcagagga atttacccaa aaaatctata atagtgtatc taatatagaa
    70021 ttatcagtta ttgcagagat aggaaaagta tcaattaatg ttgaggattt actcaaacta
    70081 gaagttggag atgtaatagt aacaaataaa aaaataaatg attatataga tatatttgta
    70141 gaaaattcaa aatcatacac agcaacacca ggatttatat caagtaaaaa aggtgtaaaa
    70201 ataaatgatg ctgttggaaa agaggtgtag ttatggacaa tagtaatctt atttcagatg
    70261 aagaagcaaa gatgttatta aatgataaag ttgaaagtga agttgatgga gatgatgagt
    70321 tagccttaga tgtctctgaa gttaatcgaa ataatataca aaggatactt gaccttaagt
    70381 tagaattatc tgtagttata ggaagaacta agatgactct aagagatatt ttaaatttac
    70441 ataaaggttc tcttattgaa ctggatactt tggcagacca agatgtggaa atactaatag
    70501 ataataaggt tttggcttat ggaaaagtag tggtggtaga tttaaatttt ggtgtaaaga
    70561 taacaagtat agtaagtgaa gaagacatgg taaaatctct tgtttagaga taacatcaat
    70621 taatacttaa ggcatgaggt ggtacttatt ttaaacttaa atgatataaa aaaagatata
    70681 ctaaaactca ataaaaaaga ctcatgttct ctatataatg aatctattaa taatataaat
    70741 aataattgta tatcaactgg attaaaattt ttaaaacaag caagagattt aaacccagat
    70801 gatgttgata tattaaatct cacaggtctt gtaaacttac taaaatgtaa ttttgatgat
    70861 gctgtagaaa gtttctataa gagttcactt tgtgaaaaaa ctgctctgtg tgaaaagtat
    70921 ataaacatgc ttacatctga ggagttttta attttctttg aaaagtacaa tcaacttata
    70981 aggttaataa ataaaggaat gtataaagaa gctatacaag ggtttaaact tataactgac
    71041 caatactgtg atttaataga accttatgag ttgcttgcct tactgtatga caaggaagaa
    71101 gaatatataa aatttgatga atgtttagaa gtattgaaga ttattgataa ggaaaattat
    71161 ttattaaatc aagaaaataa cacattatat atgtataata gtgctaatat acaaactaaa
    71221 agtaatataa aagtagatga ttataagaat gagttcttac ataaaagtag tagtaaccat
    71281 aaaattaatg attataatga tgtaactaaa gaaaagagtt caagcaaaaa ccagaaaagt
    71341 tcagattcta ataagaaaaa aagtattaaa aaaaataagt acctatatat agccataata
    71401 ttaggaatat tattagtagg acaaagtata tatagttctt ataagatgaa taatttaact
    71461 gataaaatat ctaaaaataa tgaaactaaa aatgaagagt caatagattc taacttgact
    71521 aagaaagaaa ataatataga agaaaatgaa gatatgagta aggcttctaa tataaataag
    71581 agtaataaaa acattaataa agaggatgat gtaaaatcta aaaaaaatac tgtagaaaat
    71641 gaagatgata aagattctga cttatttaca gaggatgaat tgatgtctaa ggcgaatact
    71701 ttaaaatcag aaaagaaaac taaatcttct atacaactat ataagaaagt tgcagatata
    71761 ggtgaaaata aagggaatac atctgaagca acttatcaag ttgctattct cagtgaaaag
    71821 ttaaaagact ataaaactgc tgaagaatat tataaaatgt atgtagaaaa ttactcagaa
    71881 aaagatgctt attttgatga atcttattat aatttaggta tgatgtacta taacaatggt
    71941 gatttaaaaa attctaaatt gacattaaag aagttggtta ataaggtacc aaatagtatg
    72001 tataataatt caaaagtaaa agaaatttta aaagaagaat agttaaatta gataagaaaa
    72061 ataaattatt ttattttaaa ataatatgat tataatatat tgacatacca ttttaaaaaa
    72121 tttaaaatat taattataaa atgaggaggg ataaaaaatg gaatttgaaa aagggagtat
    72181 ttcaattcat acagaaaata tttttcctat aattaaaaaa tggttatact ctgataaaga
    72241 catatttata agagagctta taagtaatgg atgtgatgca gtaagtaaac ataaaagact
    72301 tgtatcacta ggagaaatat cagaaaataa gtcatcagat tataaaatta cagtatctgt
    72361 aaataaagga gaaggtacac ttaaatttat tgacaatgga attggtatga ctgaagaaga
    72421 gataaaaaaa tacataaatc aagttgcttt ttcaggtgct gaagatttct ttaataaata
    72481 taaggataaa atggaagagt caaatgatat aataggtcat tttggattag gattttattc
    72541 tgcatttatg gtgtctaaaa aggtacaaat agatacactt tcatatacag aaggagcgac
    72601 tcctgtaaga tggatatctg aaggtggtac agaatacgaa atatctgaat cagatgctag
    72661 aaatgataga ggaactacta taacactatt tattgatgat gatagtaaag aatttttaga
    72721 tgaatttact gtaagaggaa taataaataa atactgttct ttcttaccag tagaaatata
    72781 tttagaagat gttgaaagat tagaaagaga agctaaagaa gcagaagaaa aagctaaaaa
    72841 acaaaaggaa gatggaaaag aagagattgt agatgcaaaa gtaattgagc ctttaaacga
    72901 cactaatcct ctatggttaa aatctccaaa agactgtact gatgaggagt ataaagagtt
    72961 ttatagaaag gtattcaatg tatttgatga acctttattt tggatacatt taaatgtaga
    73021 ttatcctttc aatttaaagg gtatacttta cttccctaaa ttaaaaaatg agtttgaact
    73081 gactgaagga aaagtaaaat tatacaacaa tcaagtgttt gtggctgaca atataaaaga
    73141 agttatacca gaatttttac ttttattaaa aggagttata gactgcccag acttaccatt
    73201 aaatgtatca agaagtttct tacaaaatga cagggatgta agcaaaattt ctaaacatat
    73261 aattaaaaaa gtagctgata agttgaaatc tctttgtaaa aatgaaagag aagaatacaa
    73321 taagttttgg gatgatatac aaatatttat taaatatggt tgcttaaaag atgaaagttt
    73381 ctatgagaag gtaaaagaat gtatattatt caaaactatt gatgatgagt atataacatt
    73441 acaagattat ttagaaaaat gtaaggacaa acatgaaaat aaggtatttt atgtaagtga
    73501 taaggaacag caatctcaat acattaaact atttaaagaa tacgacttaa gtgctgttgt
    73561 tttaaactca tcaatagata ctcattttat ttcatttatg gaatataaag agaatggagt
    73621 taagtttaat agaatagatg cagacctttc tgatgtatta aaagataaaa atgaaaataa
    73681 agatagtgaa gaaaacaaag aagagatagc taagatagaa ggtctgttta aagaagctgt
    73741 cggagaaaga gtgaagaatt attctgtaga aggattgaaa aatgaagaca ctccagctat
    73801 ggtattagta tcagaacaat ctattagaat ggcagaaatg cagtcaagat ttgctggaat
    73861 ggatttagga atgaattttg aggaagaaaa aactcttgta ataaatgaga acagtccaat
    73921 aatcaaaaaa ttggtttctc ttaaagatga tgaggaaaag aaagataaga ttacgcttat
    73981 ttgtaaccag atagcagatt tagctttact ttctaataaa gaattaaagc cagatgagtt
    74041 agattcattt gtacaaagaa gtaataagct tatgagtctt ttgatagaat tataagattg
    74101 aatttgaata cattgaagca aatttataaa aagtattcaa tatcagtgat aagaaagaag
    74161 tgtctcaaaa tgaacttttc agttcatgag gcgctttttt tatgtgaaat taaatttatt
    74221 ttaatcattt caacaatgaa aaatatattt atctctattt tgagacagac cattctttat
    74281 ttttttatct ttggttaatt ttaaatattt aagtaggttc taataaaaaa ctctatttag
    74341 ttaaatatag ttaacttgat atataataag ataatacata taattaagta aaagattgtt
    74401 ttttagttta tgtttaaata cataattaca ctttgttaaa aacataaaat tattactaaa
    74461 gtagaaatag gaggttttag aatgaatttt aattataatt tgccagtaaa tatcttattt
    74521 gggagaggca gaattaatga tgtgggaaaa gaagtatcta aatatggcaa aaaagtattg
    74581 atagtaacag gtaaaaatag tacaaagaaa actggattac ttgataaaac aatagattta
    74641 ctaaaagact ctaaaataga atatgaagtt tttgatagag tagaacaaaa tcctcttata
    74701 actactatat attcaggagt agaaattata aaatcaactg gatgtgattg tgttttaggt
    74761 cttggtggtg gaagcattat ggatgctgcc aagagtatag ctttttctta taaaaaccca
    74821 ggagatttaa atgattatat atttggaatt agacaaggtg aagaagcttt acctataatc
    74881 ttagttccaa caacatcagg tacaggtagt gaaggaaatt gttttgcagt acttacaaat
    74941 tcagaaacta aagataaaaa atctataaag aagaatagta tgtatgcaaa agcatcaata
    75001 attgacccag aacttatggt tacaatgcca aaacatataa ttgcatcagt tggatttgat
    75061 gcacttgccc ataatatgga agcatatctt tctaatggaa gaaaccctct tgcagatgta
    75121 caagctattt atgggattga acttatatca gaaaacctaa taaaggtata taatgatgtt
    75181 aatgatttag aagcatggga aaaaataaca cttgcaagta ctattggagg aatgacgatt
    75241 ggtacagcgg gtacagcctt gccacatgga atggagcatc ctgtaagtgg tcttagagat
    75301 gtaatgcatg gaaaaggact tgcagctttg actcctacta ttatagaaag ttcatgggat
    75361 agtgatattg aaagatttgg taatatttca aaggtattag gaggaacttg tgcagaagat
    75421 tgttcagatg caattagaaa tttccttaaa aaaatagatt tagatataaa actaagtgat
    75481 ttaggtattg aaaaatcaga tatagattgg ttaactgata attgtatgaa aatatcagtt
    75541 gcaaatatta agagacatcc aaagtatttt aataaggaac aaataaagga aatgtaccat
    75601 aagtctttat aatttgactt tacatattta gttttatata aaaattataa attaataata
    75661 aaaaattata agtaattaat agtaaaaaaa ttgtgtatag aagttatata tataataaat
    75721 ttgtcttaag cttttatttt actttctaat aaataaagga gtttaaaaaa gggaagatta
    75781 attaagtaat attttataaa attcttcgat ttaaaaactt taagtagagg tgaaataaat
    75841 gtttaatccc aaaagaataa tattcgaaaa aggaacttta gacactgatg tgggtaaaaa
    75901 aatatacaat aaatttagag ataataaaga tgtagagata attaatatat catcaaatag
    75961 gattaaagaa catattccag gtgaaaatct atatgaacaa tatagaagtg ggaagcagac
    76021 tatggtagtt gggattagaa aaagtctgaa gtttcaaaca tgtaaacctt ctgctaatta
    76081 tcaactacca cttgtcagtg gatgtatggg aagatgtgag tattgttatt tgaacacaca
    76141 attaggtgat aaaccattta taagggtgtt tgtaaatgta gatgaaatac ttgaacagac
    76201 aaaaaaatat attgaagata gaaagccaca ggtaaccata tttgaagggg cagctacatc
    76261 agacccagtt ccagtagagc catatactaa ttctttaaag aaaacaatag agttttttgg
    76321 aagagaggaa aaaggaagat ttagatttgt tactaaatac agtgatgtgg atagcttatt
    76381 ggatgctgaa cataataatc atacagaaat acgatttagt atcaatactc ctagaattat
    76441 aaatgaacat gagcattata cagcctctgc aaataaaaga atagagtcag ctgtaaaact
    76501 tgctagggct ggttatcaga ttggtttcat aatagcacct gtgtttttat atgaaggttg
    76561 gaaagaagag tataaaaatc tgattataag tataaaagaa gctttaccaa aggattttga
    76621 taaaaaaatt atatttgaag ttatatctca tagatataca actaaagcaa aaaatagaat
    76681 actagagatt tatccagata cactattgcc aatggaaaat gaggatagaa agtttaaata
    76741 cggtcaattt ggatatggta agtacgtgta tgataaagaa caattagatg atatgaaaga
    76801 gttctttctt aaggaaataa atggagtatt taaaaatagt ttaataaaat atataatata
    76861 gcaaatctta cctaaagatt tgctatattt tatttttata cattttatgt ttataataaa
    76921 gcaatgagat ttagcactat catataagaa aattaaaaag ggcactatct atcaagaaca
    76981 ttttttctag ttttgatact ataaaggata agagtaacaa aaatatcagg aggagttata
    77041 gtatgcatgc atgggagtct attcaaatta cattggattt aatagaagca aatttatcag
    77101 aagaaatatc aattaatgaa ttagcaaata aagcaaattt atcaccattt tactatcaaa
    77161 gactatttaa aagattggta aataagactg taatggagta tataaagctt cgtcgtcttg
    77221 caagagcttc tgaatactta gcagaacata agaatcgtat acttgatgta gctttaaatt
    77281 ttggatttgc tagtcatgag acatttacac gttcctttaa aaaagcatat ggattaactc
    77341 cagaaaaata tagagcaaat ccagtaaaac tcaatcactt tattaagcca gaattaattt
    77401 taaattatgc tatggttgat gaaggtgttc cactgattgc agatgatata gtgattgaag
    77461 tcaatcgtaa gacattgagt aatccaagga catttgttgg aatagaaata gaagtaccta
    77521 tttgccagtt ggtgggcggt gaaacaactg gaattgcaat agtagaggaa ttatggatga
    77581 aacttggaag tcaaagacat aatataccaa atcaaattcc aggtggaaat gaatttgctg
    77641 ctctttatat gggaaatgca aaagaaggaa attgtatgta tatggcaggt gtagaggtag
    77701 agtcaggtac atcagtagaa ggatatagta cttttgagtt gccagctaaa gaatatttag
    77761 tatgtggatt tgaggcagaa aactttaatg agttagttaa ttcagctgtt tttaaagcag
    77821 ataaatttat ggaaagatgg atgaagaaac ataatttaac aactactgat tttgcaattg
    77881 agatgtatta ccccactaca cctgaagcag catatctgga acattggatt gttccggttc
    77941 ctattgaaca atagaaagga tgatgaatat gaattggcaa gatgcgtttt ttcaagatac
    78001 taaacctaca tttgagcaaa ttaatgaatt tattaataat ccattatggg acaagttaaa
    78061 taaaactttg gtttctactt ataatgtaga acctaagctt gaatacagta aatgttcaat
    78121 gcaaagaggt tggaatgtaa aatataaaaa aagaggtaaa tcactatgta ctttatatcc
    78181 acaagaaggt tattttaaag ctttggttat tgtaagtgaa agcaatagag tagaggttga
    78241 tttatttatt aatacttgtt gtgattatat caaaaaaata tataatgagg taaacttttt
    78301 taatggaagt aaatggctaa tgattcaagt agatagttta ttggtattaa acgatatgct
    78361 tgaactaatt aaatttagag cttaacatat agaacaggat gaatatataa gtcatcctgt
    78421 ttttatattc aatcagataa attaatatat agtctataat atgaataatt tagtaaattt
    78481 aaatttactt tatctttcta cattctttgc aactaagtcc acatgtgttt ttttcttgca
    78541 tattagtagc accccaatta gcaaattgtt gtaaaatagg cacaatactt ttacctttac
    78601 ttgttaatgt atattcaact tttggaggaa tttcattata ttgtttacga tgaacaatac
    78661 cagtagactc taaatctttt aatgattgag ctagcatagt atttgtaatg ccatccaatt
    78721 ttctttttat gctactatat ctaattggat tttcaactgc taacatacat ataataggta
    78781 atttccactt accaccgaca atgtctaatg cataacggat tggacaggtt aattcttcaa
    78841 cgtttttagt tatatttttt tcagtattta tactcatttt aattactcct tagttatagt
    78901 agtatctttt ttatacttta tcagaaaaaa ctgcatactt gttttttctg tattttatat
    78961 taaaattata tcaaaggata atccttaata caagtattta aaaggggtgt aagaattatg
    79021 aaagcattag aatttttgaa caaggcacga gtttattatt tagcaacagt tgatgagaac
    79081 aatcaagcac atgtgcgtcc tttaggattt gttatggaat acaatggtaa acttacattt
    79141 tgcacatcta atcaaaagga tatgtttaag caacttattt ttaatccaaa ggttgaactt
    79201 tgttgtatag accaaaacct taatactcta cgtattttag gtgaagcagt atttgttaca
    79261 tcaaaagaaa cacaagctaa ggcacttgaa ataatgccaa gtttaggtca gatgtactct
    79321 gtaggagatg gtaagtttga aatattctct attgataagg caaaagttag ttgttgttca
    79381 atgagtggta aaaagattga tgtagagctt taattataat tgaatcgaca tccatagtga
    79441 aaattaagaa aacgttatta ctgaaatgtt gatagattta atttaaatgc aataaaaaga
    79501 tttttaaata atgaatatgt aaaaattttt agttattaga tgtgtatttc aataatgata
    79561 tactattttg aataattaca tactagaaat aagataatta aaatttactt tataatggga
    79621 tagatttctt ttaaaaaata ttttaactat aattgatttt tatttaatct gaaaaaaata
    79681 ttatgactat aaaaaattgc tacttattat ttggatattt ttatatataa ataataagta
    79741 gcatgacttt atacattaat aatgatagaa tataaattaa tagataagat atgattttaa
    79801 aaggagtgat ataagatgag taaatatagt tctttatggg aatattttaa gaaaaacaat
    79861 agtcaatcgt ttaaattaac ttttgaagaa ataaaagata ttgctgggat agagatagac
    79921 cattcgtttt tgaaatataa aaaggaatta aatgaatatg gatatcaagt aggaaaaatc
    79981 tctttaaaag agaagactgt tattttcgat aaaattggtt aagacataaa taattacata
    80041 taataaaata atttgtattg atgattatta caaataaaaa agggcgtagc actatttttt
    80101 agtgtcacag cccctttttt gtttataatt atgtacattt cacattatca cgatataagc
    80161 atttttctta tgagaaaatt aattagaatt atttttattc atatttaaat tatttaaatt
    80221 gttttcccag ttttttatct cctttttaac ttcttcactt aaagtatcac ttgaagatat
    80281 tttctttaat ttatcattca aagatttctt ttgttcctct gaaaggtctg tttttattgt
    80341 aggatcaata atatctatta catcttttac atcaaaatca acaaatttgc acagttcttc
    80401 tagatgatca attagaaaat ctagaccttc atatgaccat tctttataat cttttccgtt
    80461 ttttaataga aactcattca cttggtaatt ctgatttgct aattcaaaga atgaacctga
    80521 aggatccatt atatcattta tagagttttc atagttaaca atattaattt gtcttattaa
    80581 tttctctttt tctgttaagt tgctataatt cttgttaaca aaagctacta atccaaattc
    80641 aaagtttaaa attgaatctt tacgtttttt tactgaatct tctccaaatt ccctaagacc
    80701 ttctaaattt ttatcaatgg ctttatctct aatctctatt aattgttcta tacttaaacc
    80761 ttctaagttt ttaggtacta tttcttcatt attcttagta acttctttca atttattgtt
    80821 agtattttta ttattgaaaa taaatatagc agttaataaa cttaaaatta ttactaaaat
    80881 aattaaactt acattttttt tacttaacat attaaacctc cttttttaaa taagtattgt
    80941 acttgtgaaa aataaatttg tttatgaaga taacatttac tactgtttgt tctaaagatt
    81001 ataatagaat atttttttga tataatctat atttttctta ttaaattttc ttattagata
    81061 tttaatatca atatttttta gatagaaaag attttaataa ctccaaatat ttaataagta
    81121 aaataaaatt attgctttaa aatatatttt tatatgtttt aagttttata ataagtaata
    81181 ttgtatgata aattaaattt aaatatttag agataagcta ttatagaatt tgcttagttt
    81241 aagttaaatt ttaaaatatt caaaaag
//
LOCUS       DAEPID010000008        79253 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.008, whole genome shotgun sequence.
ACCESSION   DAEPID010000008 DAEPID010000000
VERSION     DAEPID010000008.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 79253)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 79253)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..79253
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.008"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            complement(130..324)
                     /locus_tag="KR257_000612"
     CDS             complement(130..324)
                     /locus_tag="KR257_000612"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728535.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0029339.1"
                     /translation="MFQVINFLCLFCVGFLVLDVMIYFCKDAMDIFEGTTNVNKVKSI
                     NVWADRVRANSYSYENKIAK"
     gene            complement(633..2162)
                     /gene="lysS"
                     /locus_tag="KR257_000613"
     CDS             complement(633..2162)
                     /gene="lysS"
                     /locus_tag="KR257_000613"
                     /EC_number="6.1.1.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434963.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="lysine--tRNA ligase"
                     /protein_id="HBH0029340.1"
                     /translation="MKNNQQSNEEAQIQEDLSEVLQVRRDKLKKLQESGRDPFKESRY
                     DRTHYSMDIKDNFDSLEGKTTKIAGRIMSKRIQGKAGFIDIQDQEGRIQSYVRLDAIG
                     EEEYSVFSTYDIGDIVGIEGEIFKTKKGEISVKAKSVVLLCKSLQVLPEKYHGLKDQE
                     LRYRQRYVDLIVNPEVKNAFLIRTKALKALRAYLDDRGFLEVETPILNTIAGGANARP
                     FITNHNTLHIPMYLRIANELYLKRLIVGGFDKVYEMGRMFRNEGMDLKHNPEYTAIEL
                     YQAYADYTDMMEITENVIAHMAEVATGSMIVNYQGTEINFTPPWKRMSMEDCVKEYSG
                     VDFSTINTDEEALEVAREKGIEIKPGMRRGEVINAFFEEFGEDKLIQPTFITHHPVEV
                     SPLSKRNVEDPRRTDRFEAFANKWELANAFSELNDPIDQKGRFIDQLRKRELGDDEAF
                     EMDEDFLKALEVGLPPTGGLGIGIDRVIMLLTNSPSIRDVLLFPTMKPIDNNPNKEEE
                     N"
     gene            complement(2177..2656)
                     /gene="greA"
                     /locus_tag="KR257_000614"
     CDS             complement(2177..2656)
                     /gene="greA"
                     /locus_tag="KR257_000614"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003514606.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcription elongation factor GreA"
                     /protein_id="HBH0029341.1"
                     /translation="MEENKEFLLTQEGYDKLEEELENLKVVKRKEVAERIKVAISFGD
                     LSENAEYDEAKKEQAQVEERILKLENMVRKAVIIDESKIDLNVVTIGSIVKVKDLEFD
                     EEVEYTIVGSTEADPYDGKISNESPVGKALLGRAAKEVVEVQVPDGVAKFEILEIRR"
     gene            complement(2765..3733)
                     /gene="dusB"
                     /locus_tag="KR257_000615"
     CDS             complement(2765..3733)
                     /gene="dusB"
                     /locus_tag="KR257_000615"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434962.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA dihydrouridine synthase DusB"
                     /protein_id="HBH0029342.1"
                     /translation="MKIGNLELKNKVFLSPMAGVTDLPFRLICKEQGCGLLYTEMING
                     KALCYDDENTKKMLKIEEEEHPVAVQIFGSEPEFMGRAAEIMNDYSNEILDINMGCPA
                     PKVVKNGDGSALMKNPKLAEEVLRAVVKNSKKPVTLKIRKGWDDNSVNAVEIAKIAED
                     CGISALAIHGRTREQFYTGKADWDIIAEIKKNLSIPVIGNGDVFTIEDSINMLDKTGC
                     DAIMIGRGAQGNPWIFKRINHYMNTGEILPEPTLNEKISTAIKHLKLAVEEHGEYVAV
                     REMRKHIAWYLKGLRNSAKLRDEINKIEDYQEVVSKLEYYMEDSLT"
     gene            complement(3870..4640)
                     /locus_tag="KR257_000616"
     CDS             complement(3870..4640)
                     /locus_tag="KR257_000616"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861999.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type III pantothenate kinase"
                     /protein_id="HBH0029343.1"
                     /translation="MLLVFDVGNTNMVLGIYKGDKLVNYWRIKTDREKTSDEYGILIS
                     NLFDYDNVNISDIDDVIISSVVPNVMHSLENFCIKYCKKQPLIVGPGIKTGLNIKYDN
                     PKQVGADRIVNAVAGIEKYGAPSILVDFGTATTFCAISEKGEYLGGTIAPGIKISSEA
                     LFQSASKLPRVELAKPGMTICKSTVSAMQSGIIYGYVGLVDKIISMMKKELNCDDVKV
                     IATGGLAKLIASETKSIDYVDGFLTLEGLRIIYEKNQE"
     gene            complement(4659..5249)
                     /locus_tag="KR257_000617"
     CDS             complement(4659..5249)
                     /locus_tag="KR257_000617"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892118.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ECF transporter S component"
                     /protein_id="HBH0029344.1"
                     /translation="MMNTSASVRKVNVRKMTIIGVLSAISIMLSMTPLGFIPVGPTKA
                     TIMHIPVIIGAIMEGPIVGAAIGFIFGISSLLNAITNPTVTSFVFINPLVSILPRVMI
                     GVLAYYVYQLIIKATNKVYISGLITGAIGSLLNTAGVLGMIYVLYADKYLHAMGKSGS
                     AGKVIMALAAANGVPEAIVGALVVAAVATVLKKSKK"
     gene            complement(5433..6401)
                     /locus_tag="KR257_000618"
     CDS             complement(5433..6401)
                     /locus_tag="KR257_000618"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892121.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="P1 family peptidase"
                     /protein_id="HBH0029345.1"
                     /translation="MYNNILDIEGLKVGQVEDRNGLTGCTVVICEEGATCGVDVRGSA
                     PGTRETDLLDPVNMVQKVHAVVLAGGSAYGLESTCGVSRYLEEKGIGFDVGVGKVPIV
                     VGAVLFDLGVGSFKCRPDLKMGYRACEVANTDILNQGNYGAGCGATVGKIRGQEYAMK
                     GGIGSYSIKLDNGLIVSALIAVNALGDVYENGKVIAGALNDKKTETIDTYKLMKQGES
                     KGGFSVDNTTIGIIATNAKLTKAGCKKISQMGHDGYAKSIFPIHTPHDGDTIFTISTG
                     EIEADITLVGSLAVEVVEKSIINAVKKADSVENIMAYKDIVKKREI"
     gene            complement(6394..7371)
                     /locus_tag="KR257_000619"
     CDS             complement(6394..7371)
                     /locus_tag="KR257_000619"
                     /EC_number="6.3.4.15"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422214.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="biotin--[acetyl-CoA-carboxylase] ligase"
                     /protein_id="HBH0029346.1"
                     /translation="MRDKIIEIILNNKSEFISGEELSKQLGVSRAAIWKHMKALKEEG
                     YNIESVNKKGYRLAENPTDLLSPQNIYYKLDTEFIGKNIEHLDTIDSTNEHAKRIAIN
                     SVDGTVILSEHQDMGKGRLGRRWDSKPHEGIWMSIILKPDMEPFKAPFITLIAGASVT
                     KALNNLGANTLIKWPNDVILNGKKICGILTELSAEIERTNYVVLGIGINVKIMDFEQE
                     IADKATSLYKEGYMLSRVDIVRNVLTEFEKLYLDYTVNNSKEKTLKICRDYSAIIDKN
                     IYVLKGDNRELVKCLDINEEGNLLVQRSDGSIKEIISGEVSIRGEKGYV"
     gene            complement(7686..9656)
                     /gene="ftsH"
                     /locus_tag="KR257_000620"
     CDS             complement(7686..9656)
                     /gene="ftsH"
                     /locus_tag="KR257_000620"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892124.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-dependent zinc metalloprotease FtsH"
                     /protein_id="HBH0029347.1"
                     /translation="MNKLLKGAGFYLLVFIIIVGIVQFSGKPTEKIKDLKFSEVYREL
                     TDENISRLYFVNQTSVEGTIKDTNTKFKSYVPTEVMGNKLADEVLDQAKAGKLTFGGE
                     AKPSTPWFVEMLPTLLLIFFMVIIWFVFMNQSQGGGGKVMSFGKSKAKVHKDDEKTRV
                     TFKDVAGLDEEKEDLQEVVDFLKNPKKYIELGARIPKGMLMVGPPGTGKTYLSRAVAG
                     EAGVPFFSISGSDFVEMFVGVGASRVRDLFEQAKKSAPAIIFIDEIDAVGRKRGAGLG
                     GGHDEREQTLNQLLVEMDGFGVNQGIIIMAATNRPDILDPALLRPGRFDRQVVVGTPD
                     VKGREAIFKVHSRNKPLSDDVKMDVLARRTPGFTPADIENLMNEAAILTARKREKKIK
                     METIEEAITKVIAGVAKKSKVISEKERRLTAYHEGGHAVCAHVLEEVSPVHQVTIVPR
                     GRAGGFTMQLPVEDKFYATKNEMKENIVVLLGGRVAEELVLKDVSTGASNDLERVTAT
                     ARSMVTKYGMSSKLGPMSFDSDDEVFLGNSFSSKRNYSEEVAFEIDQETKRIVDGAYD
                     KTRSILQENMDRLEYVAQALLIYETLDAEQFVKAFNKELPLNEIENAVTEENSSKEVE
                     EQLTIKLEKDEEERNNVIDINKNLEDKSDKDK"
     gene            complement(9690..11078)
                     /gene="tilS"
                     /locus_tag="KR257_000621"
     CDS             complement(9690..11078)
                     /gene="tilS"
                     /locus_tag="KR257_000621"
                     /EC_number="6.3.4.19"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898757.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA lysidine(34) synthetase TilS"
                     /protein_id="HBH0029348.1"
                     /translation="MIFDKVLSTINKHNLIQKGDKIVLGLSGGPDSVCLLHVLNRLKK
                     DFNIEIYAAHLNHQIRGIEAQKDALYVSKLCEDMGIIFFVKSINVPKYCENEGLSLEE
                     GARKLRYEMFYEIKDKIKANKIAIGHNLNDQAETVMMRIMRGTGLKGLKGIDYIRDNC
                     IIRPILDVERNEIEEYCEAYNLNPRIDKTNLENIYTRNKIRLDLLPYMKDNFNSNVIE
                     SIVRMSNSLKSDNDYIEKEAEAKFREVSNIKEKGFVEINLDDFVCLHDAIKVRVLRNS
                     IKHILGDTNFVDQRHIEDIMSLEDNSKVNKMLTLPRNIFVYRKKDSIILTNEEIVNEE
                     IEFYYNVPSNGFIKIKELKQIIETQVMSIDRYKSMKLDNSSKGFDFNKVKGGIVIRSR
                     RQGDKIKLAMGSKKVKDLFIDLKIPREERCKIPIITDSEGIICVGDYKISENYKIDEN
                     TKEVLKINFNKL"
     gene            complement(11261..11689)
                     /locus_tag="KR257_000622"
     CDS             complement(11261..11689)
                     /locus_tag="KR257_000622"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012816442.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1934 domain-containing protein"
                     /protein_id="HBH0029349.1"
                     /translation="MEEKSLSVKISINTRQYDEKGNMDTIEMTAFGKIFYKNDGIYVI
                     YKEKEEDIEITNTIKILKNQVSIKKFGAINSTMLFKCGESSTTKYVTPQGTLLIDIDT
                     RELDINIQEGEHIKLKIDYNIKVQDLFLGRNKIDIYIGTK"
     gene            complement(11706..12512)
                     /locus_tag="KR257_000623"
     CDS             complement(11706..12512)
                     /locus_tag="KR257_000623"
                     /EC_number="5.1.1.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425992.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glutamate racemase"
                     /protein_id="HBH0029350.1"
                     /translation="MNNKPIGVFDSGLGGLTVLKEIMKILPNEDIIYFGDTARIPYGS
                     RSKETIIKYTFQAINFLKTKGVKAIVIACNTATARSLKEAQEKYDIPIIGVIEAGART
                     AVSSTKNKIVGIIGTEGTISSKAYNLEISKIDESIEIVNKACPLFVPIVEEGWANTEV
                     AKLTAKIYLQELKEKNIDSLVLGCTHYPILKRTIGEEVGEHIKLVNPAKETAKDLKKI
                     LEVQNIINNTEIHGTYQYYVSDIPEKFSDIAREFLKKKIDKIQKVEIQKY"
     gene            complement(12714..13199)
                     /locus_tag="KR257_000624"
     CDS             complement(12714..13199)
                     /locus_tag="KR257_000624"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009906547.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell wall hydrolase"
                     /protein_id="HBH0029351.1"
                     /translation="MATLLALTFIFMPIKEVFAYEPTENIKKVNKQEKNIAKKEVINL
                     SDNDLMLLSKLVAGEARGESYEGQVAVAAVVINRVLDPRFPDTIEEVIYQKNAFSVVL
                     DGSIKMAPTDSARKAAQEALYGTDPTNKAVYFWNPEIATCKWINRLNPYMRIGNHVFA
                     K"
     gene            complement(13250..13909)
                     /gene="spoIIR"
                     /locus_tag="KR257_000625"
     CDS             complement(13250..13909)
                     /gene="spoIIR"
                     /locus_tag="KR257_000625"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425996.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="stage II sporulation protein R"
                     /protein_id="HBH0029352.1"
                     /translation="MRKIKIRLGLLILSLISVISIMTIVINGEVKKVDNISKDYKDKL
                     IRFHVIANSNTDEDQELKLKVRDEVIKYLQPKLQNSKSIKESEAIIKKEYSSLEEISK
                     NIILKNGYNYSVKVGIQYSNFPTKQYSNIVLPAGEYKALKIIIGKGEGKNWWCVMFPP
                     LCFVDESNGVIDKSTDDKLKEVLTDKEYKLIKQDTPKKTSRVKIKFKVLEVVKDLEKK
                     F"
     gene            complement(14054..14734)
                     /locus_tag="KR257_000626"
     CDS             complement(14054..14734)
                     /locus_tag="KR257_000626"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009906549.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GntR family transcriptional regulator"
                     /protein_id="HBH0029353.1"
                     /translation="MENLTKLNLDNYKPLRDVVFENLREAILEGKLKPGQRLMEVQLA
                     EQLGVSRTPVREAIRKLELEGLVVMLPRKGAYVANMSLKDIMDVLEVRASLEGLAAYL
                     AAERISDEDIKKLKDISEEFKKSTLESDVDALLKLDVEFHECIFKATNNKKLIQLINS
                     LWEQVYRFRVTYMSAYDTSHNIVEEHKYLLDAIIKGDSELSKKYATEHIEKAEQFMID
                     KAMISKDL"
     gene            complement(14718..15608)
                     /locus_tag="KR257_000627"
     CDS             complement(14718..15608)
                     /locus_tag="KR257_000627"
                     /EC_number="2.7.1.148"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004453273.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="4-(cytidine
                     5'-diphospho)-2-C-methyl-D-erythritol kinase"
                     /protein_id="HBH0029354.1"
                     /translation="MDFIRLKSRAKINLSIDVLGKRQDGYHFVEMIMQTIDLYDIVKI
                     KELDEDEIKVKSTSLDIPLDEDNIVYKAAKILKNKFYIKKGVEIFIEKNIPVAAGMAG
                     GSSNAAAVLVGLNHLWELRLSEDELKEIGLNLGADVPFCISGRPALAQGIGEKLTNIK
                     GLPCDTNILICKPDLFVSTKEVYQGLDLNNIKKRPNNKYLIECLKSEDIKAVSESMVN
                     ILENVTIGKHKEISDIKQVMMKNNALGSMMSGSGPTVFGLFKNKEDALIGKKELLKKY
                     KQVYVVNSSQKGVEICGEFN"
     gene            complement(15726..17276)
                     /locus_tag="KR257_000628"
     CDS             complement(15726..17276)
                     /locus_tag="KR257_000628"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898760.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3794 domain-containing protein"
                     /protein_id="HBH0029355.1"
                     /translation="MELIKDVIKVDNRIDFGKFQTFIEAEAVVPDKKLDVYEIVKTEG
                     YISLKKIEMADGKILCRGSFNYNVIYIADDKNTISNVDGKVDINEVIEKDNVVQDMEY
                     MLFSEVEHMDCTIMNERKIKVGALMNIRGSLFEKQRLDIVKDVAQVEGIQKHRKEICF
                     QDIVGIEKAESSIRDTITINTEEIQSIISLNPCVKVKESRVTDNKVIIGGVLEINPLA
                     CTYEGELVELDRVGIEFTQFVEVPGVSDGMTEEVLLSMSDFNHIFKQNSESNTGLLEI
                     DCMACCKVKVTDEVTREVLQDAYSPQKIIKFDHKPIQLNKTLRRSEETFMVREGIRND
                     NDDIQIKDIVSVCPTMSIENSYIEGNKSIIQGIIKVEILFVPVEGLKLVYKISEEIPF
                     EHDIEMDNLTDTASVFNTACIDKVEVDLNRDQIDLIIKIKRFTEALDKKAENFIIKGE
                     DQGVYDLSKAPSIIVYICKEGDTFWNIAKKYNTTENEIAELNDIKLDEPIKPGKCLIL
                     EKKVVLVD"
     gene            complement(17370..17636)
                     /locus_tag="KR257_000629"
     CDS             complement(17370..17636)
                     /locus_tag="KR257_000629"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892135.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Veg family protein"
                     /protein_id="HBH0029356.1"
                     /translation="MATVQTLDKIRVSLERHIGKKILLKANKGRKQIITKEGILEKVY
                     PSVFVIKLDDESNGYPRVSYSYSDLLTSNVKLQVFRDQDKLQIS"
     gene            complement(17784..18644)
                     /gene="yabG"
                     /locus_tag="KR257_000630"
     CDS             complement(17784..18644)
                     /gene="yabG"
                     /locus_tag="KR257_000630"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422239.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sporulation peptidase YabG"
                     /protein_id="HBH0029357.1"
                     /translation="MKVGDIVARKSHNKDIVFKIVSFGVDENNEKIAILKGIAFRVIA
                     DAYIDDLELVKAPDIKDILIDKNVENLLYKSVRKAKERQKRMTRAVPKLQLNPNTYGM
                     PGKVLQIDGDKEYLKICLDVYAQLGIPAVGVAVSEQNQYKEVRALLEKYNPDILVITG
                     HDAMTIKRGDIEDMSNYRNSSNFVKTVKEARKWQPNLDNLVIFAGACQSNYEKIISAG
                     ANYASSPGRIMIHALDPVFIVEKIACSRIDVVVPIDEVIEQTITGVKGIGGSETRGKF
                     RWAMPKTILH"
     gene            complement(18728..19666)
                     /locus_tag="KR257_000631"
     CDS             complement(18728..19666)
                     /locus_tag="KR257_000631"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898762.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dipeptidase"
                     /protein_id="HBH0029358.1"
                     /translation="MKFIDLHCDTIAKLMENVETSELKSNKYSVDIDRLKKGDSLAQT
                     FALFVDTEEVKHPFDYCMSMANKFHEEMKKNSDEIALATNYEEIMKNQSEGKLTALLS
                     IEEGAVLEGKLENLKKFYDLGVRMMTISWNHVNELSFPHNKVEYREKGLTDFGREVVH
                     KMNELGMLVDVSHISDGGFYEIAKISSKPIIATHSNSRAMMNHSRNLTDDMIKVLANK
                     GGVTGINFFHLFLSDKSESKLEDMVRHIKHIVNVGGIDVVSLGSDFDGIDSKVEIEDI
                     SQMGKLYEPLKKEGFSEDDIEKIYYKNALRVIKEVL"
     gene            complement(19776..19937)
                     /locus_tag="KR257_000632"
     CDS             complement(19776..19937)
                     /locus_tag="KR257_000632"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426006.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0029359.1"
                     /translation="MFILRFADDDDNLSVKDFTSLTDLKKYISENNIDKTWHQIEEVK
                     KVIPNLKEE"
     gene            complement(19947..20444)
                     /locus_tag="KR257_000633"
     CDS             complement(19947..20444)
                     /locus_tag="KR257_000633"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434936.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SEC-C domain-containing protein"
                     /protein_id="HBH0029360.1"
                     /translation="MSLYTEWRNLSDNHESQEAEVKFWEEYLKVEAGIYNEILNNKMD
                     VVEGKVSELAEKFGTTNEFFMGFIDGISESLKEDIVLEEVEADKEVSIKIDWEKLYNN
                     MVTVEAHWLYNLQGWEDILPADQRKEIIKAYKKSKTIVKEAKIGRNDSCPCGSGKKYK
                     KCCGK"
     gene            complement(20559..21269)
                     /locus_tag="KR257_000634"
     CDS             complement(20559..21269)
                     /locus_tag="KR257_000634"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434933.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="UPF0489 family protein"
                     /protein_id="HBH0029361.1"
                     /translation="MENYEYSGFYIEKPVGNNVFSYDKRENKSIYVPKLINGTLNDVR
                     LGNEVVFNEVDENKEIKAKGLENMVEYVLGNKKIYVFDNHNHAFYFWAKSLLKGEFTK
                     GCKLVHVDQHKDTREPENYDVDVNNLKDVFRYTNEVLNVGSFIKPALKYNIFSELIII
                     DSLYGFDLEVESEFVLDIDLDIFSSDMDYIPFELKFYKIKNLIKKAKVITIATSPYFI
                     NQEYAIKVLKELFNYDII"
     gene            complement(21445..21975)
                     /locus_tag="KR257_000635"
     CDS             complement(21445..21975)
                     /locus_tag="KR257_000635"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434931.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0029362.1"
                     /translation="MDIRALPIRITKEEAIEIAKSGKNSLFSKLILKNKYAHEVRLHY
                     IEFKIITLKIHKTKSIFKNRRYSNDINELKILVNGSTGSGSIVQDFPTYEVVKNVDCN
                     IVQYSDKDERRVKAKANKMAMRLTHRFMGGIPEIEIVKIESIFRPYWVVFFGKVELNR
                     RVSYLPIEADGFVIGM"
     gene            complement(21992..22222)
                     /locus_tag="KR257_000636"
     CDS             complement(21992..22222)
                     /locus_tag="KR257_000636"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434928.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0029363.1"
                     /translation="MSKLVSKVKKDLEIKWLGIDGFLVLLYFLITGFIFYGILTRNDI
                     IVGKIIPYGVMSVVIVIFFDYIYRVLKMTRKK"
     gene            complement(22237..23631)
                     /locus_tag="KR257_000637"
     CDS             complement(22237..23631)
                     /locus_tag="KR257_000637"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892151.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sodium:solute symporter family protein"
                     /protein_id="HBH0029364.1"
                     /translation="MLTFWENGIIVIFAFILLGIGYYFSRNVKDMESYYLGNRSLPWS
                     LIVGTLVASWYGGVGTVGSVEYAAIYGISAWAVWSIAAHIGRMPLALWVGPRIHIRTN
                     ITVPDLLESFYGKHVAIIGAILMFIYCAQLGEITAMGTIGNVAWKIDKELIGLIMVGV
                     VVVLTVLGGLMGVAITDMVLFFCMVFGLTMVMPGQFEQIGGFQGLTEALKDAPQLMHP
                     TKGMSAMKALMLIVYSFGAYSDPTFYQRFSAADSPKVGRRALLTCFSLWICFDMVLTM
                     TGLIVRATYPEMAPAAGYITLVLDTLPQGIRVIFIIGILGSIISTLDSYYLAAGATLA
                     NDIYGRITKKELSQKQLVKFTRIGVCLAAVMGLSVAFRFENVYDACIFVGSIWMGSAF
                     VPIVGGLLGNGRRTSMGGILGMIVGGVTFGYFKIFPVQSFELEPLVIAIPFSFIAWMI
                     GNRIGENLNTQNNL"
     gene            complement(23757..25010)
                     /locus_tag="KR257_000638"
     CDS             complement(23757..25010)
                     /locus_tag="KR257_000638"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892153.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MFS transporter"
                     /protein_id="HBH0029365.1"
                     /translation="MESKNNVKRFLIIFILAFGTTAMYSLPYMKSSFYDPMQQALALS
                     HTQIGNLLSLYGLVGMVSYFIGGWFADRFSVRKLITFSLIASGILGFYFSTFPSYSMI
                     LLIFVLWGFTTILTFFSASVKVVRMQGSESEQGRIFGFYEGLSGVSGTLISFIGLYFF
                     GKFAEITVGFKYVVWLYSAASIICGILLFFLVEEKKDSGASDEGLSIKSLLKVVTMPK
                     AWLIGLIIFSTYLVFSSLTYLSPYLSEVYVMPMTLVSALSIIRTYVIKMGASPVAGVI
                     TDKVGSSIRVMFVGFILMTVSTAAYLVIPKSTGFIWIAVINMIILSVILFGFRGIYFA
                     SVSESNISLETTGAVVGFASFIGFSPDAFYYTIAGNWLDKYGQTGYTYIFILSVVCAV
                     IGIFATYALNKINKRENKGLNNKIA"
     gene            complement(25061..26215)
                     /locus_tag="KR257_000639"
     CDS             complement(25061..26215)
                     /locus_tag="KR257_000639"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892155.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aminotransferase class I/II-fold pyridoxal
                     phosphate-dependent enzyme"
                     /protein_id="HBH0029366.1"
                     /translation="MSNNINQDLETKIIHWGHSADPTTGALATPICQTATFAAKTVEH
                     FEELCMTWGYVYTRECNPTLTELEAKLAMLENAESAISSTSGMGAITSTILALVKSGD
                     HIVSSDGIFSHTKLFMSELLSKFGVEVTFVDAVNPQNVKEAMRPNTKIVYIESPLNPS
                     LDLVDIKTIAEIAHENKSLAIVDSTFGTPIVQRPIDLGADLVIHSLTKFINGHGDTLG
                     GAVAGSKELIDLVRWPSLCCFTGASLPPMSAWMILRGMKTLDMRMKKHCENGLAVAEF
                     LEEEENVELVKYPALKSHPQYELCKTQMNGLGGGVVSFKLKDGINGLTRDQASRRLMN
                     SLELATIATSLGEEHTLVQMNGENLIRIAVGLESSNDIINDFKQAIEKLK"
     gene            complement(26775..27344)
                     /locus_tag="KR257_000640"
     CDS             complement(26775..27344)
                     /locus_tag="KR257_000640"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426023.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
                     /protein_id="HBH0029367.1"
                     /translation="MIIIYGYCRVSTKNQTDNNSLYQQQQEILNKYNDAKIIKETYTG
                     TTTNRPKFEKIISSLKKGDLLVATKLDRLARSTSEGIQLIEGLFAKEVSVHILNIGLL
                     ENTSMGKFFLTTLLAVAELERNMIIERTQLGKEFAKKKKDFKDGRPKKYSNQQIQYAL
                     GLLNSKPYREVVKMTGISKSTLIRAKKSI"
     gene            27547..27774
                     /locus_tag="KR257_000641"
     CDS             27547..27774
                     /locus_tag="KR257_000641"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009906553.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="single-stranded DNA-binding protein"
                     /protein_id="HBH0029368.1"
                     /translation="MNSLLKEAIDELKNIHCGEVFLLKELFKGYEWNRLEMNIRLKLG
                     KLFLYEVVTNPNLNVEVINKNSAYQQMYKKK"
     gene            complement(27993..28736)
                     /locus_tag="KR257_000642"
     CDS             complement(27993..28736)
                     /locus_tag="KR257_000642"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434912.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3298 domain-containing protein"
                     /protein_id="HBH0029369.1"
                     /translation="MENYQSTNTCTYNILYVQFNEDFERSKYFSYDVKYPVIYNIRNQ
                     STYVNPVILNNINNAVRMTVNNFKNGLQEEEREYNNATSQNSLPKQSYWVSTSYAVTF
                     NKNYVLSMILNLMGFANNYGPKYNTLNNYNIDLTTGKELLLNDIFRDGVDYINIITDY
                     IKSQINENREMYYSNVELVIPEDQAFYLTDNGIIIYFGVDEIAPESFGIPKFELKFSD
                     FGNFINLRFYCISPDIYVQSRGRAKHFMG"
     gene            28904..29776
                     /locus_tag="KR257_000643"
     CDS             28904..29776
                     /locus_tag="KR257_000643"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422265.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="HBH0029370.1"
                     /translation="MLLLADKWKDYELIDMGNGEKLERWGSYVLRRPDPQVVWPMESE
                     WALWKNPHGHYHRSNKGGGQWEHKKRYPEQWTINYKNLKFHIKPTGFKHTGLFPEQAA
                     NWDWMIEKIKKANRPIKVLNLFAYTGGATVACASAGAEVCHVDAAKGMVNWAKENIEL
                     SGLKNQTVRFIVDDVVKFVEREIRRGKKYDAIIMDPPSYGRGPKGEVWQIEEKLYSFV
                     DLCMGVLSDNPLFFLINSYTTGFSPIVLENVLSTTIGKKTNTGDIYGGELGIPASRDG
                     KILPCGIFGRWEKK"
     gene            29776..30441
                     /locus_tag="KR257_000644"
     CDS             29776..30441
                     /locus_tag="KR257_000644"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892161.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RluA family pseudouridine synthase"
                     /protein_id="HBH0029371.1"
                     /translation="MIKVIYEDNHLLVVEKPVNILSQGDNTNDKDMVNLLKDYIKKKY
                     NKPGNVYIGLIHRLDRPVGGVMVFAKTSKAASRLSEQVRSKTFKKTYLAVVHGKIKSN
                     SDILKDFLYKNKKTNMVTVVKKSHKDAKEAELNYNVLDFKENLSLVQVNLKTGRSHQI
                     RVQFASRKHPLYGDQRYGKEINKIGQQISLWSNKIEICHPTTKEKMEFTCHPPDKYPW
                     NIF"
     gene            30462..31319
                     /locus_tag="KR257_000645"
     CDS             30462..31319
                     /locus_tag="KR257_000645"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892163.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MerR family transcriptional regulator"
                     /protein_id="HBH0029372.1"
                     /translation="MSKKFSIGEMSKLHKISIQTLRYYDQIDLFKPVHVDQESNYRYY
                     SIDQFSQLDIIKYLKYLGMPLKEIKSKLDENNEEILKLLTNKINIVDEKIKELELIKK
                     VLSTKKETMEKGMKVDEVGKIVRKHIPRRSILSIEYEEGLSSEETMELSRRQIANILE
                     DNISVFYGGVSGLVSIDKFLKEDKVIYDNSFVTVERDLFDIKSQKHITEISSGDFICM
                     TYKGPYKENYTAFKKLVDYVEYKRIPIENYIYEIPIIDPLSTNNEEELLTEIQIQVKK
                     REIDLRCLV"
     gene            complement(31475..34021)
                     /locus_tag="KR257_000646"
     CDS             complement(31475..34021)
                     /locus_tag="KR257_000646"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434900.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="FtsX-like permease family protein"
                     /protein_id="HBH0029373.1"
                     /translation="MNIFNKVALQGLKKNRTRTLVTIIGVVLSAAMITAVTTFGVSLM
                     NYMTNGAIIKYGDWHVQFLDVDSSFVQEQRVNDEVANTATFENIGYATLEGNRNPDKP
                     YLFIAGFSKEAFDTLPITLISGRLPENSREILVSSKVATDGGVKFAVGDTISLDVGKR
                     MSENEKLGQSDPYTAGSEVFVPQDKKTYTVVGICRKPVFEESSAPGYTLITKEDKQVK
                     TDSLSLFVTLKNPHQIRSYISSTKDHASIFNDNVLRFIGVSDNNLFNMFLYSVGGIVL
                     AIIMLGSIFLIYNSFNMSLNERTHQFGILSSVGATAKQLRNSVLFEGICIGAIGIPIG
                     VAIGIVSIGLVISVIAKNFANILYVNVPLTLTLSIPAIIVAAVVSMVTILISAYIPAR
                     KAANTPVMECIRQTNEVKIESKSVKTSKLTQRVYGLEGVLAMKNFKRNKKRYRSIVLS
                     LVLSIVLFISTSALVADLKQMSNQRSEVTDQDIIFSTQGMKDNEMLKLYDKLKTANGV
                     YEGLYQKLMTYSCVAKVSELTDDYLNYEGSHSMSEMLELPVDMQFLDDRTYLNIIKSL
                     GLPAEEYTGQNAKLIAVSMVTKDNNIIDIFNSSSMNVSLTPETNGKLEIPERQNVNIS
                     FVKVVPPDSPPGIRSSDVKKASFRVLAPYSAKDKFEIPGVSTGIESLSFQSKNPTQSV
                     AEMEQIIESEGVTNEYNLYNMYGMMDENRNYIFIANVFAYTFIIMISLISIANVFNTI
                     STNIKLRRRELAMLRSVGMSEHDFQKMMNFECAFYGMRALFFGLPIAVISSWLIHKVM
                     VTDDIDFVIPWFSIGISIFSVLFIVFITMLYTINKIKKENIIDALRDDMA"
     gene            complement(34021..34707)
                     /locus_tag="KR257_000647"
     CDS             complement(34021..34707)
                     /locus_tag="KR257_000647"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422273.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBH0029374.1"
                     /translation="MAFLKIEDLCKVYGKNENKVTALDHVSLTIEKGEFTAIIGSSGS
                     GKSTLLHSIAGVDVPTSGKIYLEGQDVYGQSNEKLAIFRRRQVGLIYQFHNLIPTLNV
                     VENITLPILMDKRKVNQERLNDLLELLGLKERKTHLPNQLSGGQQQRVAIGRALMNAP
                     AVMLADEPTGSLDSKNGQEIIQLLKESHSKYHQTLIIVTHDENIALQADRIICISDGK
                     VVRDERKVNR"
     gene            complement(34790..35779)
                     /locus_tag="KR257_000648"
     CDS             complement(34790..35779)
                     /locus_tag="KR257_000648"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434897.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HAMP domain-containing histidine kinase"
                     /protein_id="HBH0029375.1"
                     /translation="MFRNREFRKFAILFLLITILTVALGFAISIMTGILSIVSATTFG
                     IAFFVFTKNRYKSIAQISEQINLVLHNANHLYIAESDEGELSILQSEITKMTLRIREQ
                     NYALKKEKEHLADSLADIAHQLRTPLTSVTLILSLLENTSDEDERKELIRETEELLIR
                     MDWLITSLLKLSRLDAGIVVFQKEQIDVNNLISSALHQLLIPMELHNITLHIDIPKGV
                     RILGDLNWLSEAIQNIFKNCMESVGDNGKIDIICEDNFLFTQLTIHDNGAGFKKEDLP
                     CLFNRFYRGKNSSTAGYGIGLALCKTIIMRQGGTITAQNHPQGGAIFVIRFPK"
     gene            complement(35766..36452)
                     /locus_tag="KR257_000649"
     CDS             complement(35766..36452)
                     /locus_tag="KR257_000649"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434895.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HBH0029376.1"
                     /translation="MKRIFLVEDDKAIAKNLILLLNSEGFIVTHVSTRSEALVEIAKN
                     KFDLALIDISLPDGNGFTICTEIKEKQDIPVIFLTASGDESSVVTGLNMGADDYITKP
                     FRPRELIARIRTALRKSGRFGSTFEICGLYVDTATGVVKKNGNEVFLSALEYRLLLVF
                     ISNPKSIITRVRLLDELWDAAGEFVNDNTLTVYIKRLREKIEDDPSSPQIILTVRGTG
                     YRLGGSYVSK"
     gene            complement(36952..40158)
                     /gene="carB"
                     /locus_tag="KR257_000650"
     CDS             complement(36952..40158)
                     /gene="carB"
                     /locus_tag="KR257_000650"
                     /EC_number="6.3.5.5"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011862003.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="carbamoyl-phosphate synthase large subunit"
                     /protein_id="HBH0029377.1"
                     /translation="MPKLDSIKKTLVLGSGPIIIGQAAEFDYSGTQACQALKEEGIEV
                     VLVNSNPATIMTDKEIADKIYIEPLTIEFIEKIIEKEKPDSLLAGMGGQTGLNLAVEL
                     HDAGILDKYNVKVIGTSIESIKKGEDRDLFREVMKEINQPVIVSDIVTNLEAGLEFAN
                     KIGYPVVVRPAYTLGGTGGGIADTEEELREILSHGLQLSPVGQVLLEKSIKGWKEIEY
                     EVMRDGNGNCITVCNMENVDPVGVHTGDSIVVAPSQTLSDEEYQLLRKASIDIINAIE
                     VQGGCNVQIALNPHSLEYAIIEINPRVSRSSALASKATGYPIAKVAAKIALGYTLDEI
                     ENAVTKKTYACFEPTLDYVVVKIPKWPFDKFRHANRKLGTKMMATGEIMSIGSNFEAA
                     ILKGIRSLETGKYSLVHAPSEGRTLEELKARVVVPDDERLFDLAEMIRRGYKVEMISE
                     ITGVDKWFINKFKWIVEQEEKLKVLKIEDLDKEYLHELKKKGFSDKGISDLMKISPEK
                     LYELRSLYNIQPVYKMVDTCGGEFEALSPYYYSTYEQYDEVVVSDKRKVVVLGSGPIR
                     IGQGIEFDYCSVHCVKSLRKMGIETIIVNNNPETVSTDFDTSDKLYFEPLTEEEVLNI
                     IEKEKPEGVILQFGGQTAIKLAKFLHEKNIPILGTDFRDIDAAEDREKFDDLLERLDI
                     NRPKGKGVWTTNEGVEIAKELGYPVLVRPSYVLGGQGMEITYNEEKLIQYLDDAFDRD
                     HKNPVLIDKYLTGREIEVDAICDKEDILIPGIMEHLERAGVHSGDSTTMYPSQNISDE
                     IKEKIVEYTKKIALDLNVLGMVNIQFIEFQNELYIIEVNPRASRTVPYISKVSGVPIV
                     DLATKCMLGAKLKDLGYSTGVYKEPKLVSVKVPVFSMSKLSKVEVSLGPEMKSTGEVL
                     GVGENLEEALYKGFLAAGRHMSDERGVVLATVNNHDKDEFIEIAKDMKELGYTFVATE
                     GTAKSLRENGIEADIVNRIEEPRPNILDAIRNKQVDIVINTPTKGNDSTRDGFKMRRT
                     AIEFSTEIMTSLDTLKALVEVKKKHLNKDKLKVYNIAE"
     gene            complement(40351..41400)
                     /gene="carA"
                     /locus_tag="KR257_000651"
     CDS             complement(40351..41400)
                     /gene="carA"
                     /locus_tag="KR257_000651"
                     /EC_number="6.3.5.5"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002845470.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glutamine-hydrolyzing carbamoyl-phosphate
                     synthase small subunit"
                     /protein_id="HBH0029378.1"
                     /translation="MKARLILEDGTVFIGKAFGYLEESVGEVVFNTSMIGYGEVLTDP
                     SYYGQIVTMTYPLVGNYGINLSSAESEKVQVKGFIVREKSDSPSNFRCEIDIDQYLKQ
                     NKVIGLEGIDTRALTKILRNNGTMKGIITLEDSKLEDVKHKLDKFSNTEAVRTVTRKE
                     VEHIKGNGPKVAVMDFGVKRNILRSFIARGCDITIFPATTSPEDVLSINPDLIFLSNG
                     PGDPEDLEDVIENIKALIGKKPIVGICLGHQLLALALGGKTAKLKFGHRGGNHPVKDL
                     EEGKVFITSQNHGYYVSEVPEQMKVTHINLNDNTVEGMRHEKLDVYSVQYHPEACPGP
                     KDNDYIFDKFLELVK"
     gene            complement(41657..44863)
                     /gene="carB"
                     /locus_tag="KR257_000652"
     CDS             complement(41657..44863)
                     /gene="carB"
                     /locus_tag="KR257_000652"
                     /EC_number="6.3.5.5"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011862003.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="carbamoyl-phosphate synthase large subunit"
                     /protein_id="HBH0029379.1"
                     /translation="MPKLDSIKKTLVLGSGPIIIGQAAEFDYSGTQACQSLKEEGIEV
                     VLINSNPATIMTDKEVADKIYIEPLTIEFIEKIIEKERPDSLLAGMGGQTGLNLAVEL
                     YEKGILDKYGVKIIGTSVESIKKGEDRDIFREVMKEINQPVIVSDIVTDLQAGLDYAL
                     TIGYPVVVRPAYTLGGTGGGIADNEEELREILSHGLQLSPVGQVLIEKSIKGWKEIEY
                     EVIRDSKGNCIVVCNMENIDPVGVHTGDSIVVAPTQTLSNKECAMLKKASLDILNAVE
                     VQGGCNVQFALNPHSFEYAVIEINPRVSRSSALASKATGYPIAKVSSKIALGYTLDEI
                     ENAVTKKTYACFEPTIDYVVAKIPKWPFDKFKKANRKLGTKMMATGEIMSIGSNFEAA
                     ILKGIRSLETGKYSLVHTPSEERSIEELKKRVVVPDDERLFDLAEMIRRGYKVEMIEQ
                     ITGIDKWFINKFKWIVEQEEKLKVMKIEDLTKDYLLELKKKGFSDKGISDLMKISPEK
                     LYELRSLYNIKPAYKMVDTCAGEIDAISPYYYSTYEQYDEVVVSDKKKVIVLGSGPIR
                     IGQGIEFDYCSVHCVKSLRKMDIETIIINNNPETVSTDFDTSDKLYFEPLTEEEVLSI
                     IEKEKPEGVILQFGGQTAIKLAKFLHEKNIPILGTDFDDIDAAEDREKFDDLLERLDI
                     NRPKGKGVWSLNEGIEVANELGYPVLVRPSYVLGGQGMEITYNEEKLSQYLQDAFDRD
                     HKNPVLIDKYLTGREIEVDAICDKEDILIPGIMEHLERAGVHSGDSTTMYPSQNISDE
                     IKEKIVEYTKKIALDLNVLGMVNIQFIEFQNELYIIEVNPRASRTVPYISKVSGVPIV
                     DLATKCMLGAKLKDLGYGTGVYKEPKLVSVKVPVFSMSKLSKVEVSLGPEMKSTGEVL
                     GVGENLEEALYKGFLAAGRHMSDERGVVLATVNNHDKDEFIEIAKDMKELGYTFVATE
                     GTANSLRENGIEADIVNRVEESRPNILDAIRNKQVDIVINTPTKGNDSTRDGFKIRRT
                     AIEFSTEIMTSLDTLKALVEVKKKHLNKDELKVYNIAE"
     gene            complement(44916..45959)
                     /gene="carA"
                     /locus_tag="KR257_000653"
     CDS             complement(44916..45959)
                     /gene="carA"
                     /locus_tag="KR257_000653"
                     /EC_number="6.3.5.5"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011862004.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glutamine-hydrolyzing carbamoyl-phosphate
                     synthase small subunit"
                     /protein_id="HBH0029380.1"
                     /translation="MKGKLILEDGTVFEGKAFGYLKEAIGEVVFNTSMAGYGELLTDA
                     TYYGQIVTMTYPLIGNYGINLEDVESNKVQVKGLIVREKSDNPNNFRCEMDIDTYLKQ
                     NKVIGLEGIDTRALTKIIRNNGTKRGIITLENVSLQDVQSKLEEHCNKDSVKNVTRKE
                     IENIKGTGAKVVVIDFGVKNSVLESLKACNCDITIVPAMTTVEEILNINPDLILLSNG
                     PGNPEDINDIVENIKKLIGKKPLTGIGLGHQILALALGGKTSKLVFGHRGGNHPVKCL
                     ETGKVFITSQNHGYNVSEMPENTEVTHINLNDNTIEGMRHKELPIYSVQYIPEYTTKE
                     DLDCIFNKFLALI"
     gene            complement(45985..46701)
                     /gene="pyrF"
                     /locus_tag="KR257_000654"
     CDS             complement(45985..46701)
                     /gene="pyrF"
                     /locus_tag="KR257_000654"
                     /EC_number="4.1.1.23"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422297.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="orotidine-5'-phosphate decarboxylase"
                     /protein_id="HBH0029381.1"
                     /translation="MINGKEKLIVAIDTDEFDKAKELIDRLEDSVDIFKVGLEQYVAT
                     KGKTIDYLKEKGKKIFLDLKFHDIPNTMKSAVKAAVRDNVWLMTIHVSDMEGMRQCAL
                     IAREEAERLNIEKPLVVGVTVLTSLSNQDLQDIGCNMTTEELAIKRAKLAKESGIDGV
                     VCSAQEVDKIVEACGTDFITVCPGIRPKSAEVGDQKRVVTPSDAIKKGAHYLVVGRPI
                     TKAENPRESAINIVREIENA"
     gene            complement(47077..47712)
                     /locus_tag="KR257_000655"
     CDS             complement(47077..47712)
                     /locus_tag="KR257_000655"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422299.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1847 domain-containing protein"
                     /protein_id="HBH0029382.1"
                     /translation="MYKCGKCNLRGCSNGNMDKLMKICPTREIELQQKAKQLYEEEEN
                     RKIAYNAGLVEAEGYCQYTRLKEIIEFAKKCGYKKIGIAFCIGLKREMQTVQKIFEHH
                     GFEVFSVICKNGAMPKSTIGLEASQTISKCSDEVMCNPIGQALFLNEAKVDLNVILGL
                     CVGHDTLAMKYMEAPITTLVVKDRVTGHNPVAAIYNAESYFEKKLFDKDEE"
     gene            complement(47736..48650)
                     /locus_tag="KR257_000656"
     CDS             complement(47736..48650)
                     /locus_tag="KR257_000656"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892179.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0029383.1"
                     /translation="MELYEAIFYRKSVRNFSSKKIKKPLMEEIKRSCKNLEYLNEDLN
                     IKAHVVDRGHIIHFLMGKECKVKAPHYIVVTSDKGEDYLQNIGFATEGVVLRLTTLGI
                     ATCWLEGNLKREDILEFVDIGNKNFEEDEEDDLDYLAGIKTEEDDENKIENPYIIIAF
                     GYPAKNEELFRTRYARPDRKPVKDMINKINRNRKWKDILELTRRAPSVKNSQPWYFHK
                     DERGLHLFEKRPKKHCEDMNKVSLGVALRHFDIACIKNKIDVSYEKLPIRNKIGKSYF
                     ITVVEHVKPEEETQEENVTLEKEESQDE"
     gene            49251..50480
                     /locus_tag="KR257_000657"
     CDS             49251..50480
                     /locus_tag="KR257_000657"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429165.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aminopeptidase"
                     /protein_id="HBH0029384.1"
                     /translation="MNLNRNLEKYAELAIKVGVNIQPGQILLIKSPIECADFARNALK
                     EAYKCGAKNVYIEWSDEESTLIKYLYAPDEAFHEFPKWTAEQYVDIAKEGGAFLSVYA
                     QNPDLLKDVDPERVANFQKASGKALKEWRSYTLTDKCKWNIVSVPTKDWAKKVFPNLS
                     EDKAIEKLWDAIFKCSRVDGQDPIKAWEEHNENLKSKMDFLNKNNFKTLKYKSSKTDL
                     TLDLPKGHVWLSGASKDPNGISFNPNIPTEEIFGMPHKFKVNGTVYSTKPLVYGGNII
                     DNFFLTFKDGKIIDFSAEKGLDTLEKLIETDEGSHYLGEVALVPYNSPISNTDIIFYN
                     TLYDENASCHFAIGSAYKTCLEGGNNLKDEELDEHGVNDSLTHVDFMIGSADMDIIGE
                     TYDGKQIQIFKNGNWAF"
     gene            complement(50685..53066)
                     /locus_tag="KR257_000658"
     CDS             complement(50685..53066)
                     /locus_tag="KR257_000658"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729141.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="homocysteine S-methyltransferase family protein"
                     /protein_id="HBH0029385.1"
                     /translation="MEIRQYLKNNILIFDGAMGTMLQQKGLKLGENPEVFGLQNPDKL
                     IEIHTAYLEAGSNVILTNTFGCNELKLDSKYTVEEVIDNAVLVARKAIENVDNTKPRY
                     VALDIGPIGEMLEPMGTLSFDKAYEIFKRQVLQGVKSGVDVIVIETMMDLYEAKVAVL
                     AAKENSDLPIFCTMTFDEGGRSFTGCMPECMVATIEGLGVDAIGVNCSLGPKQLLPIV
                     EKIASRATVPVMVQANAGLPNIVDGEAIYDVDAKEFFEGVKKFVEVGATIIGGCCGTN
                     PSFIKEISENINSVTKGCIEKIDKCVVCSPSKFVEVQSPTVVGERLNPTGRKSLQEAL
                     KNENVDYAINLGLEQVNAGAQILGVNVGLPEIDEKKLMPKLIREIQAVVDTPLQVDSS
                     NVEALEQGLRYYNGRTIVNSVNGKEESLESILPIVKKYGSCVVGLTLDEKGIPKKAEE
                     RFEIAKRIVNRAVSYGIKPKDIFIDCLSLTVSAQQEEAIETIKAITMVKTLGVKTILG
                     VSNISFGLPNRKALNASFLTLALGAGLDLAIINPNEYSMMEAINSFKILNNTDKGCIN
                     YINQYSNINNSKKSDSSTKIDKDLPLDILVERGLKDEAKNVTLNLLKEKDENYILDEI
                     LIPALDKVGKRYDSGDIFLPQLIQSAETVKVSLNTIKETLLSKSSNNVSKGKIIVATV
                     KGDIHDIGKNIVKIMLENYGYEVIDLGKDVPIEEVVEVAKKRNIKLVGLSALMTTTVQ
                     SMKDTIQALRDNEINAKVFVGGAVLTEEYAEEMGADYYSKDAKSAVEIAKLNF"
     gene            complement(53038..53763)
                     /locus_tag="KR257_000659"
     CDS             complement(53038..53763)
                     /locus_tag="KR257_000659"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422307.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Vitamin B12 dependent methionine synthase,
                     activation domain protein"
                     /protein_id="HBH0029386.1"
                     /translation="MENNLIGREDISINQSEVLRYLQYRGQEIDKDLKYTIDECVAIT
                     KNKINPRYLSRIYPIRINKDNVVELEGTNLTLESKYVYELLKECNECVIMAATIGIDI
                     EKEIRRHSYSNLTKGLIIDSCGTTAIEEVCDIVQNNLEKVFLKQDKFITMRYSPGYGD
                     LPIEKNIDILNVLNAQKQIGLTITSNGIMIPRKSVVAIIGISNTRINKSKKEKSCENC
                     KNYRNCTYRKGANSCGNKTISEK"
     gene            complement(53753..54208)
                     /locus_tag="KR257_000660"
     CDS             complement(53753..54208)
                     /locus_tag="KR257_000660"
                     /EC_number="4.4.1.21"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429171.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="S-ribosylhomocysteine lyase"
                     /protein_id="HBH0029387.1"
                     /translation="MEKVESFKLDHTKVKAPFVRKCSVLDGVKGDKVTKFDLRFLQPN
                     VESFGTAAMHGLEHLLATYLRDTLDGVIDLSPMGCRTGFYLILWGDVDAKTVKIGLEE
                     ALKKVLESDKMPAATAIECGNYRDLSLFGAKEYAKDVLDKGFSLNIYGE"
     gene            complement(54490..55671)
                     /locus_tag="KR257_000661"
     CDS             complement(54490..55671)
                     /locus_tag="KR257_000661"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729142.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GHKL domain-containing protein"
                     /protein_id="HBH0029388.1"
                     /translation="MKNKSLLNHMFRPILDLIISCALTSMLILTSMYIIKSLYVNSDM
                     SVVNQLVYQARDFRSLIGYDLFYPFLFTITSLAIYSIISYKRNKQIVDFIRKTNRKNQ
                     KLEIIKSAVNLMDEGNLEKSIDIEYDLDILKDKEKDDIDELAHKINNIVHQLRNITIE
                     ERQAQQTKTDLITNVSHDLRTPLTSIMGYLGVIEEGKYKDEVQMMYYVDIAYEKSKNL
                     NVLINDLFELTKMQNNTIKLNKIEINLVELLSQVVSQFEIYFKQEFMVSRINFNEEKL
                     IVKADPNKLVRAFENLITNAVKYGKDGHYVDIVTEKKEDMAVVKVINYGEPIPVLDLP
                     NIFDRFYRVEKSRNRNVGGSGLGLAITKNIVNLHDGEITVSSDKYQTVFEVQLPIIQS
                     A"
     gene            complement(55661..56353)
                     /locus_tag="KR257_000662"
     CDS             complement(55661..56353)
                     /locus_tag="KR257_000662"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011948339.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HBH0029389.1"
                     /translation="MNNTVLVVDDEKEIRDLIEIYLLNSGYNVIKAEDGKEALDILKK
                     ENIHLMILDIMMPKMDGIEVCRKVRESLNIPILMLSAKSEDMDKIQGIMTGADDYLTK
                     PFNPLELTVRVKSLIRRAYYFSGANNEDKDVIKVGVVIIDKEKHSVTVAGNEIILTSR
                     EFDILYLLANNKGRVYSTEEIFEKVWKEKYYQSNNTVMVHMSRIRDKIEKYTDGEKII
                     HTVWGVGYKIEK"
     gene            complement(56487..57203)
                     /locus_tag="KR257_000663"
     CDS             complement(56487..57203)
                     /locus_tag="KR257_000663"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422315.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="M15 family metallopeptidase"
                     /protein_id="HBH0029390.1"
                     /translation="MKKFKLIGAIILVVFISVFISKDRLLKKDKDPIVAAQHDSEQDV
                     EANSQNKNHSNSISNILLVNKTNGISKNYTPENITKVNIPFVEEATEEEKQMAGEPAK
                     AVEDLVKQANSEGIQFLGSSAYRSYDTQLDTYTRRVKSQGREKADAYVAKPGYSEHQT
                     GLCIDLTNPERWFVGSTKEAKWLAENAHKFGFIIRYPEGKEDITGTAYEPWHIRYVGK
                     DAAEEIYSKGLTLEEYLQNK"
     gene            57328..58062
                     /locus_tag="KR257_000664"
     CDS             57328..58062
                     /locus_tag="KR257_000664"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009894078.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA 2-thiocytidine(32) synthetase TtcA"
                     /protein_id="HBH0029391.1"
                     /translation="MSIQKLLSKARKAIQDFDMIQENDKIAVGLSGGKDSLTLLHILK
                     SYQRFSPQNFELIAITLNTGGVDNSPLDKLCKEINVPFYEFQTDIKEIVFDIRQEKNP
                     CALCANLRRGALNDNAKKLGCNKVALGHHKDDAIETFLMSMFYEGRVNCFSPKTYLDR
                     QDLTVIRPMVYIEEYMTKKISKDSNYPIITNPCPANGHTRREYIKNLIANLNKEMPDF
                     KRNVFGALNNSEKLFIWDKEKIKNFK"
     gene            complement(58347..59198)
                     /locus_tag="KR257_000665"
     CDS             complement(58347..59198)
                     /locus_tag="KR257_000665"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892187.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="metallophosphoesterase"
                     /protein_id="HBH0029392.1"
                     /translation="MNSKIKYFLKFFILIFILIFIYSVAIEPSLLIVKKYNISENGTL
                     IKSDTIESKSERIKVVQISDTQIGSFYSTKNLKKVANKINTLNPDIIVFTGDLIDYSN
                     KNPSVDEITTILSSMNARLGKFSVFGNHDYMYKLPRYYRQIMKNSNFNLLVNENKKIK
                     LKDDKYINILGVDEILNGNPNIKYLESQIDNKNFNLLLAHEPDLVDMLSKDTMNLVLS
                     GHSHGGQIRLPIKGALVTPPYGRKYTKGFYDINGNHLYVSSGLGSTKLPFRFFNIPEI
                     IEFNIII"
     gene            complement(59224..60162)
                     /locus_tag="KR257_000666"
     CDS             complement(59224..60162)
                     /locus_tag="KR257_000666"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429183.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SDR family oxidoreductase"
                     /protein_id="HBH0029393.1"
                     /translation="MKSILIMGGSDFIGSALAKRLIKCGYQIDILTNGKKEIDYNGFK
                     EHLICDRKVRKDMENIITGRKYDYIYDMTAYTKEDVSNLIDFISMDNLKKYIVLSAGA
                     VYKDSGRNIKEENEKGENENWGKYGLNKKEAEDFIINSPIPYIIIRPTYIYGENNNLY
                     REYYFFEKIEKNEKIPVPKGKQVSNQFIYIGDLVKVLESIMKNPHVREAYNVTNPQLI
                     SWDDLIYTCGEIIGKEPIIKYVDMEKVEFRERTYFPFRNIDFNLDINKLIEHGLYIPN
                     VLLKEGLTATYKWFSANKPKMHDRKMNKVESVMQIV"
     gene            complement(60265..60915)
                     /locus_tag="KR257_000667"
     CDS             complement(60265..60915)
                     /locus_tag="KR257_000667"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422319.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HAD family hydrolase"
                     /protein_id="HBH0029394.1"
                     /translation="MKKNYEIVLFDLDGTLTDPKEGITKSIQYSLNSFGIKEDLENLD
                     QFIGPPLHDTFKEYYKFEDKKTKEAVEKYREYFADKGIFENKIYENIKEILEMLYKNG
                     KILLVATSKPTVFAETILRYFDIDRYFKYIAGSNLDGTRVNKNEVIQYVLDLCNVKDK
                     DKVIMVGDRKYDIIGAKKIGIDSIGVLYGYGSFEELSESEPTYIVENVESIKDILL"
     gene            complement(61065..61253)
                     /locus_tag="KR257_000668"
     CDS             complement(61065..61253)
                     /locus_tag="KR257_000668"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422320.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ferredoxin"
                     /protein_id="HBH0029395.1"
                     /translation="MKAFVDKDVCVACGACIGTCPDVFSMSDEGHSVAIEGEIPADLQ
                     DLCKEAEEGCPVSAITVK"
     gene            complement(61360..62544)
                     /locus_tag="KR257_000669"
     CDS             complement(61360..62544)
                     /locus_tag="KR257_000669"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009894081.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amidohydrolase family protein"
                     /protein_id="HBH0029396.1"
                     /translation="MKNLLIRNGTIISPTDGIKFEKRDILVLHGKIYAIGLNLKEKIR
                     KEKLLTNKEFEIINADNMYISPGFIDVHTHCYKRKLPTGMDSDSIGIEKGSTVIFDAG
                     TAGPLNYYDFKKKYMDECKTEVYSFLNVTNEGLNILNESTSLDVINFDKVESVVEKNI
                     EKIKGIKVKASKFQSNESGIDIIKKSKQVAKKLNLPLVVYIGEYPSYIDEVMNILGKG
                     DVVTPVYGNSTNGILKESGTLRKSVINAKNRGVLFDVCHGLNQFDFKVFKKAIKQGLE
                     PDLISTDMHIKNMKDVNYSLLSVINKIMELGISLEKCIEKVTEYPTKIFDLHGNKGRI
                     KIGGEGDFTIFTMEECNDIIKDYNNNELVLNKKLRLQYTVKSWMKSSEVYRHGYENTI
                     IN"
     gene            complement(62686..63603)
                     /locus_tag="KR257_000670"
     CDS             complement(62686..63603)
                     /locus_tag="KR257_000670"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429188.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SufD family Fe-S cluster assembly protein"
                     /protein_id="HBH0029397.1"
                     /translation="MNKIDLNLLEKVAELRGTPLGAYNIRKNGQGVERHSTENVTIIP
                     KTDKPGIDIIVKPNTKGENVHIPVIVTETGVQDMVYNDFEIGENADVVIIAGCGIHNC
                     GCDDSEHNGIHRFFLRKGARLKYVEKHYGEGDGEGKRILNPVTIVNMDEDSYCEMETI
                     QIKGVDSTKREMDANLGKGAKIVVFEKLLTHGNQVAESNMKVILEGENSSAQVVSRTV
                     GQDNSKQKFNPCVIGDSLCSAHVQCDSIIMGNSQISAIPEIAANHPDALLVHEAAIGK
                     IAGDQILKMMTLGLTEEEAEQQILNCFLK"
     gene            complement(63625..64353)
                     /locus_tag="KR257_000671"
     CDS             complement(63625..64353)
                     /locus_tag="KR257_000671"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429190.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="HBH0029398.1"
                     /translation="MLEIKNLSFNVESNNEELGIINDVSLSFERGKLIVITGPNGGGK
                     STIAKLIMGIEKATSGQIILDGEDITNLSITERAKKGIGYAFQQPPRIKGMTVENLLT
                     LAHGKPLSTDVCCQYLTDVGLCSKDYLNREVDNSLSGGEMKRIEIATLFARDLKVSIF
                     DEPEAGIDLWSFGKLNESFKKIHEESNQTIIIISHQERILELADEIIVLQDGSVKSHG
                     TKEAILPEIMCQVNSSCELMKDMN"
     gene            complement(64549..64749)
                     /locus_tag="KR257_000672"
     CDS             complement(64549..64749)
                     /locus_tag="KR257_000672"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420681.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0029399.1"
                     /translation="MFKKMAVLKDIATKIGRKKAYELLEMVEGNDAFVAEVKIKKNGI
                     ESKKEEIMLKDNQKIILEYIEG"
     gene            complement(64874..65254)
                     /locus_tag="KR257_000673"
     CDS             complement(64874..65254)
                     /locus_tag="KR257_000673"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729145.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="VOC family protein"
                     /protein_id="HBH0029400.1"
                     /translation="MINKIGKITLYVNNQEDAKLFWTEKLNFVVTYEKEMGPNMKWVE
                     VAPSKNEFTTFVLYDKNLMMRQNKEINVSHPSIILSTRDINGTYEQMANNEVEVGELM
                     EMPYGRMFSFKDQDGNDYLVREDK"
     gene            complement(65527..66885)
                     /locus_tag="KR257_000674"
     CDS             complement(65527..66885)
                     /locus_tag="KR257_000674"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729146.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MATE family efflux transporter"
                     /protein_id="HBH0029401.1"
                     /translation="MFIRKNVIKLAIPIMIEQTFVMLLGVFNTMMAGHIGEEAVSAVG
                     MVDSINNIFISVFAALSVGATVVVAQQIGKKDGEKVNETIKQALVSGVILSFTITILM
                     WVFRTGVINLFYGSAEELVKSNAKLYIEFTLFTYPFIATQQIANGLLRGCGDVKKPMY
                     VTMFMNIVNVTLGYILIYGIDLNPLGINLQTPSYGITGAAISIAIARIIGCIVIIRAL
                     FKGNEFISMGKIFPFKIDVETQKSIFNIGIPAGVEQLLFNAGKLIVQVFIVTMGTSAI
                     ASNAIGMSIASIINVIGNALALSATTLVGQYIGRGDIKGAKSTLLYLTKFATICLFIV
                     GAIFIPIAPWISSMYTQNASVIDISTQLIRSDCLAMVIWPISFVLSAGLKGAGDTRYT
                     MMTAVIGMWIFRIFTGYVLGVVLEFGVLGIWIGMYTDWLVRGTLYCLRLRGTKWLKHK
                     VA"
     gene            67333..67785
                     /locus_tag="KR257_000675"
     CDS             67333..67785
                     /locus_tag="KR257_000675"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892191.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0029402.1"
                     /translation="MVNLNANNLNVNMVYPISSTAPIRFRRYTVSYLENMENIYLTIA
                     TYFDTLGLGTMNIDKVYGQWAWFTDNIYDLNLFVFVGNYPYQIAKNRYDTFVDILPVA
                     ITSIVNGDRIFLISNPCLLNSKITVRFISSHPTLNRTVDYGNIRDFIF"
     gene            complement(67942..68559)
                     /locus_tag="KR257_000676"
     CDS             complement(67942..68559)
                     /locus_tag="KR257_000676"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903837.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF488 domain-containing protein"
                     /protein_id="HBH0029403.1"
                     /translation="MEIFAIGHSNYPYDKLINMIKKYDINCVVDIRETPYSKYNIQYN
                     KEAFNESLRNSGFLYIYMGKEFGAKRTNKDVYTQEGYADFEKVAKEDIFLNGIERLKK
                     GCQMGYRIVLLGAMQEPIRCHRSILVGKVLNKEGFDVKYIMHEGNLAYQEDIEESLLD
                     KYFSDRKQLSIDNLLGSALTREEMIQEGYKLANKEIGYRTEKLGK"
     gene            complement(68982..69794)
                     /locus_tag="KR257_000677"
     CDS             complement(68982..69794)
                     /locus_tag="KR257_000677"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420667.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MerR family transcriptional regulator"
                     /protein_id="HBH0029404.1"
                     /translation="MFSIGMFSKINKITTKTLRYYEDIGLLKPEYVDEFTKYRYYTTE
                     QLPKLHQIITLKQMGLSLAEIKKAVENPEEVENILMNKEKEMLDVIKSEEYKIIKLRN
                     YLMNLKGEVNMNDVIIKSLPKVKVASMRKVLKGYDELFNLFPNVMAEEMMKTGCTCAV
                     PDYCFNIYHDGEYRETDMDVEMCQAINDLKEDTDILKFKELDAVENAVCILHNGPYST
                     LGKTYADAFKWIEDNKYKVVGNPRESYIDGIWNKESEEDWLTEVQIPVKRML"
     gene            complement(69870..71288)
                     /locus_tag="KR257_000678"
     CDS             complement(69870..71288)
                     /locus_tag="KR257_000678"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420665.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="potassium/proton antiporter"
                     /protein_id="HBH0029405.1"
                     /translation="MTELMIISGLVLLICITSSKVLYKFGVPILLIFILLGMLFGSDG
                     MVGIYFDNYELTKQLCSIGLIFIMFFGGFGTNWNMAKPVAIPSILMSSLGVIITAGVT
                     GMFCHMVIGTSLLEGLLIGAIAASTDAASVFAVLRSQKLNLKGSLASLLEVESGSNDP
                     IAYMLTLILLTLMNNSGVELIAPMVIKQIAFGLAIGFILAKLSVYILRHSNFEIEGFY
                     TIFITAIAILSYAFSEYLGGNGYLSVYISGIIIGNSRIPLKKSLVHFFDGISWIMQIM
                     LFFMLGLLSFPSKLPNVFGIAMAISIFMIVIARPLATFIVLAKFKFSNKEKLFISWVG
                     LRGAASVVFAIYAVTQGVAIENDIFHIIFFIALLSVGIQGSLIPTVARKLDLVDDNTP
                     VLKTFNDYDGEISSKLIEVNVDEGNKWANKSIIDSNIPDDILIVMIKRKEQVLIPKGS
                     TIIKTGDILVLSGDRIEELIQL"
     gene            complement(71772..72689)
                     /locus_tag="KR257_000679"
     CDS             complement(71772..72689)
                     /locus_tag="KR257_000679"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011862008.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF2268 domain-containing protein"
                     /protein_id="HBH0029406.1"
                     /translation="MVNMNIIEIRSDKIYKKIMDAPINKKEDIYRYELMKPFEFKWKC
                     MNVPIVARQKGGYDVIIASEMLGVLSPKDIDEKQKKNINVLSADKIWATCKETIENSI
                     NAFIKEGYDLNIKDYKYSILLANPNSPYTILSDGYWGDGGIPGYIFLSLVPNEYTINR
                     LPVLIAHECNHNIRFQFIEWNNNITLEEMMINEGLAENFATWMFGEEMLGPWVSRTDI
                     ETLNTYIKPIIKSALKETGFQNITSYLYGDDIAKMQGYFPVGLPYCAGYACGYYMIKY
                     YLEKTNKSIIEATLLPYSEIIEAVKEFWE"
     gene            72951..73328
                     /locus_tag="KR257_000680"
     CDS             72951..73328
                     /locus_tag="KR257_000680"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729148.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="VOC family protein"
                     /protein_id="HBH0029407.1"
                     /translation="MLTPYLIFNGTCEKAFNFYAEAFGGGKTIFARLDSNPNNPIMHA
                     SVTFTKYEGCIMGADTDKPVVISGMAICVVLPSREAIEEISVKLAEGGTLVQEFLPHP
                     PPHQNDGAAEVLDRYGYTWYLST"
     gene            complement(73484..73933)
                     /locus_tag="KR257_000681"
     CDS             complement(73484..73933)
                     /locus_tag="KR257_000681"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011862010.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HBH0029408.1"
                     /translation="MKSGIILEMKQINSTEYDEMLQVWESSVRATHDFLTEKDIESLI
                     PLVEIGLKEVENIVCIKDNDIIKGFIGIDKDKIEMLFIEDKYRGNGIGKKLIKYAIDK
                     YNVKYVDVNEQNKKAVGFYIHLGFKVFDRSEIDGQGNPFPILHMKLI"
     gene            complement(74100..74504)
                     /locus_tag="KR257_000682"
     CDS             complement(74100..74504)
                     /locus_tag="KR257_000682"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429200.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YmaF family protein"
                     /protein_id="HBH0029409.1"
                     /translation="MSYQNYKCERDYVYDDYKYNKCNKCYNDYEEMTHVHEYSESVKL
                     AEECEDRHNHRAAGVTGEAIPINGGTNHVHKINDNVDFLDHFHKICVTTGPAIRIPGT
                     DKHIHLICGETTVNDGHCHKFLFTTQIEAPLV"
     gene            complement(74617..75483)
                     /locus_tag="KR257_000683"
     CDS             complement(74617..75483)
                     /locus_tag="KR257_000683"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898806.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pentapeptide repeat-containing protein"
                     /protein_id="HBH0029410.1"
                     /translation="MIDIHKNIYDNKLFEELKIDCKKCFGLCCVALYFSASDGFPIDK
                     ESGKPCINLQPDFKCSVHNSLMKRGFKGCTAYDCFGSGQKVAQVTYKGIDWMQSSELT
                     NQMSEVFLIMRQLHEMLWYLKEASVLNISDTIKSKIDLIIEETEKITNMSPEQIINLD
                     IISHRIKVNLLLSQASESVMGKVKSFIKTSTLKNMKKLSKNIDLIGADLRKINLIGAD
                     LRGRFLIAANLRNTDLSGANLIGADLRDCDIRGANLENSIFLTQLQVNTAKGDSSTKL
                     PASLIRPKYWEK"
     gene            complement(76053..76397)
                     /locus_tag="KR257_000684"
     CDS             complement(76053..76397)
                     /locus_tag="KR257_000684"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000212737.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alkylphosphonate utilization protein"
                     /protein_id="HBH0029411.1"
                     /translation="MENLPNCPKCNSEYTYEDGTLLVCPECSHEWALGLGAEEDSNII
                     KDVNGNVLNDGDSVTVIRDLKVKGSSSSIKIGTKVKNIRLIHDSSDGHDIECKIDGFG
                     AMKLKSSVVKKA"
     gene            complement(76586..77203)
                     /locus_tag="KR257_000685"
     CDS             complement(76586..77203)
                     /locus_tag="KR257_000685"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892262.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBH0029412.1"
                     /translation="MISLINISKKFKDKSIIDKFNLEISKGEFVAITGNSGSGKTTLL
                     NIMGLLEKPNSGDIIINNIKNPNSKQIRILQRDFYGYLFQNYALIENENVENNLKIAL
                     KYQKNINHNKKINYALESVGLRKYNKKKIYELSGGEQQRVALARVILKECEVIFADEP
                     TGNLDKKNRDIVFDILKSLNKNGKTIVFVTHDLELSEQADRVIKL"
     gene            complement(77208..>79253)
                     /locus_tag="KR257_000686"
     CDS             complement(77208..>79253)
                     /locus_tag="KR257_000686"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435766.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1430 domain-containing protein"
                     /protein_id="HBH0029413.1"
                     /translation="ISVMFKDYKKLNKNYSKWIKDIADENNVTISKYVFNNNEKLSIY
                     TTDTSLNNNIKLKSGKFPNTNSNEFISNINTNNSNQVGKFSTMSKDISILIRDFGKIS
                     EVGESGILYISTQNEDTINKILRELNVDRSIFVARLHDRYVNSNLYLNPSIIRDLILI
                     ILCFLATIIHYSISVSREASILRLNGYSKLDIIARVIKNILRIMILSSVTALLIYIIY
                     ILKLNIGVRACLYFAMFSIICILINILISILIVGFNSRSSKYVLSLNGKKSYGFVNIM
                     HFTLKIVFVSFLILSINNCILNYNMLQTQLGNLSEWDKAKNVYNLTLKDTGEQSLGKE
                     EVIKNAKIKGFYKNLVEEKDAFLIDSTNFEKLEDGSYMYEINSKGKNPEVSQYGKNIK
                     INKNYLKVNPIYSNGKEIFNLIDYDDKTINLLVPKKLQVHENEIKKEFRELFYFEKIE
                     VENMYNKELNRALNKTKKSDLNVNIIYVDNNQSYFTYNSLVMDDNRNLIDDPIAIVDI
                     DNIDDSFYLSYISRCVYFNSKKLDALADISSIIEAQGVEAHIQSLHAVYNEYGLEINK
                     LEKYLNSEIFTIIIIAISNLMITYNIVASYYERNKYKLYIKKIFGYSTTARSMLLIVS
                     LILTNIIPIGIISTRVDLSNNIILFGLLILVIEVIVSIVLDKIISNSSFNKIIKGEH"
BASE COUNT        25205 a        14308 c         8511 g        31229 t
ORIGIN      
        1 tttcgtcaat actttttttg ttttttattt taaaaaaggt tataactttt gtttttttta
       61 ataaatataa ttaaaactaa tagatataac ccttgatatt acaaacaata catgcatata
      121 taattttacc tattttgcaa ttttattttc ataagaatat gaattagctc tcactctatc
      181 tgcccaaaca tttatactct taactttatt aacattagtt gtaccctcaa aaatatccat
      241 tgcatcctta caaaaatata tcataacatc aagaaccaaa aatccaacac aaaataaaca
      301 taaaaaatta attacttgaa acatcagaca ttcccccaat aattttttat atatagtatt
      361 ctcataaatt attcttttta ccttctcata aattattcta aatattttca taataaatta
      421 ctttcaatca tattttctaa atataaagtc tcaatcaaca aaaactaata tcaatttcta
      481 acgtttgttg gtaatttata aattaaatat ctaaaagaat ctttgaagca tataaaaagc
      541 attctacact gacattttaa ataaaattta gctatttatt gataatttaa tagctaaact
      601 ttatttaaaa cttagtagaa tgctaatatt tcttagtttt cttcttcttt atttggattg
      661 ttatcaatag gtttcatagt cgggaataat aatacatctc ttatagatgg agagttagtt
      721 aataacataa ttactctatc tatacctatt cctagtcctc ctgtaggagg tagacctacc
      781 tctaatgctt ttaagaaatc ttcatccatt tcaaaagctt catcatcacc taattctctt
      841 tttcttaatt ggtctataaa tcttcctttt tggtcaatag ggtcattaag ttcagaaaat
      901 gcattagcta actcccactt attagcaaat gcctcaaatc tatcagttct tcttgggtct
      961 tcaacatttc tcttagataa tggagatact tcaactggat gatgagttat aaatgttggt
     1021 tggattaatt tatcttctcc aaattcttca aagaaagcat ttattacttc tcctcttctc
     1081 attccaggtt ttatctctat acctttttct ctagcaactt ctagtgcctc ttcatctgta
     1141 tttatagtag aaaaatctac accagaatat tctttaacac aatcttccat actcattctt
     1201 ttccaaggtg gtgtaaagtt tatttctgtt ccttgatagt taactatcat acttcctgta
     1261 gcaacttcag ccatatgtgc aataacattt tctgttattt ccatcatatc agtatagtct
     1321 gcatatgctt gatataattc tattgcagta tattcaggat tatgttttaa atccatacct
     1381 tcatttctaa acattcttcc catttcataa actttatcaa atccaccaac aataagtctt
     1441 tttaaataca attcattcgc tattcttaaa tacattggta tatgtaaagt attatgatta
     1501 gttataaatg gtctagcatt tgccccacct gctatagtat ttaatattgg agtctcaact
     1561 tctaaaaatc ctctatcatc taagtatgct cttaatgctt ttaatgcttt tgttctaatt
     1621 aaaaaagcat tttttacttc tggatttact attaagtcaa catatctttg tctatatctt
     1681 agttcttggt cttttaatcc atgatatttt tctggtaaaa cttgtaaaga tttacatagt
     1741 aatactacag atttagcctt tacagatatt tcaccttttt tagttttaaa gatttctcct
     1801 tcaattccaa ctatatctcc aatatcatat gttgaaaata cactatattc ttcctctcct
     1861 atagcatcta gtcttacata agattggatt cttccctctt ggtcttgaat atctataaag
     1921 ccagctttcc cttgtattct cttgctcatt atacgtcctg ctatttttgt agttttaccc
     1981 tcaagagaat caaagttatc ttttatatcc atagaataat gagttctatc atatctactt
     2041 tctttaaaag gatctctacc tgattcttgt aattttttta gtttatctct tcttacttga
     2101 agtacttcac taaggtcttc ttgaatttgc gcttcttcat tgctttgttg attatttttc
     2161 atttttttcc tccaaattat cttcttattt ctaatatttc aaacttagca actccatcag
     2221 gaacttgcac ttccacaact tctttcgcag ctctacctaa aagtgctttc cctacaggag
     2281 attcgtttga tattttacca tcatatgggt ctgcttctgt cgaaccaact atagtatatt
     2341 caacctcttc atcaaattct aaatccttaa ctttaactat tgatcctatt gtaacaacat
     2401 taaggtctat tttgctttca tctatgataa cagcttttct aaccatattt tctaatttta
     2461 aaattctttc ttcaacttgt gcttgttcct ttttagcttc atcatactca gcattttcag
     2521 ataaatcacc aaaagatata gcaactttta ttctctctgc aacttctttt ctctttacaa
     2581 cctttaagtt ttctaattct tcttctaatt tatcatatcc ctcttgtgtc aataaaaact
     2641 ctttattttc ttccattata aatacaactc cttcacaaat ttcttaggaa ttttcctaat
     2701 tatattttaa aaattttata atcttttttt aatttatgcg ctatattata agtcactatt
     2761 atttttatgt caaggagtct tccatatagt actccaattt cgacacaact tcttgatagt
     2821 cttctatttt gttaatttca tcccttaatt ttgcagagtt tctaagtcct tttaaatacc
     2881 aagcgatgtg ttttctcatt tcccttacag ctacatactc tccatgttct tctactgcaa
     2941 gttttaaatg cttaatggca gtacttattt tttcgttaag agttggctct ggcaaaatct
     3001 cgcctgtatt catataatgg tttattcttt taaatatcca agggttacct tgagcacccc
     3061 tacctatcat tatagcatca caaccagttt tgtctaacat atttattgaa tcttctattg
     3121 taaatacatc accatttcct ataacaggta tactcaaatt tttcttaatc tctgcaatta
     3181 tatcccagtc tgctttgcct gtataaaact gttctctagt tcttccatgt attgctaaag
     3241 cacttattcc acaatcctct gctatctttg ctatttcaac agcatttaca ctattatcat
     3301 cccagccttt tcgaatcttt aaagtcactg gcttttttga gttcttcact actgccctca
     3361 atacctcttc tgcaagctta ggatttttca taagtgctga accatctcca tttttaacta
     3421 cttttggagc tggacacccc atatttatat cgagaatctc atttgaataa tcattcatta
     3481 tctctgctgc tcttcccata aactctggtt ctgaaccgaa tatctgaact gctacaggat
     3541 gttcttcctc ttctatctta agcatttttt tagtattttc atcatcatag caaagtgcct
     3601 taccatttat catttctgta tataaaagcc cacatccttg ttctttacaa attaatctaa
     3661 atggaaggtc tgttacacct gccataggtg atagaaaaac tttatttttc aattctaaat
     3721 ttcctatttt cattgttttt ctcctatttt tgcctttatt ttgtgattta actttaaatt
     3781 cttatttcct cattataata taccacatat agctagaaat ctatcataaa aagggaattg
     3841 gatatataac ccaattccct gtatattaat tattcttggt ttttttcata tattattctc
     3901 aatccttcta gtgttaaaaa accatctaca taatctatac ttttcgtctc tgaagcaatc
     3961 agtttagcta acccacctgt agctataacc ttaacatcat cacaattcaa ttctttcttc
     4021 atcatactta ttattttgtc aactaaacca acatatccat aaattattcc agattgcatg
     4081 gctgatacag tactcttaca aatagtcata cctggcttag ctaattctac tctaggtaat
     4141 ttagacgcac tttgaaataa cgcctcacta gatattttta ttcctggtgc tattgttcca
     4201 cccaaatatt cacctttttc agagatagca caaaatgtag ttgctgttcc aaaatcaaca
     4261 agtatacttg gtgctccata cttttctatc cctgctacag cattaactat tctatctgcc
     4321 ccaacttgtt ttggattatc atattttata tttagacctg tttttatgcc tggacctact
     4381 attaatggct gttttttaca gtactttata caaaagtttt caagagaatg cataacattc
     4441 ggaactacag atgatattat aacatcatca atatcactta tattcacatt atcataatca
     4501 aataggttac ttattaggat tccatattca tcagacgttt tttctctatc tgttttaatt
     4561 ctccagtaat taactaattt gtcaccttta tatataccta aaaccatatt agtatttcca
     4621 acatcaaata ctagaagcat atgtcattaa ccttctttct attttttgct tttcttaagt
     4681 acagtggcaa cagcagctac tactaaagcc cctactattg cttctggcac cccatttgct
     4741 gcggcaagag ccattattac ttttcctgct gaaccacttt tacccattgc atgaagatac
     4801 ttgtcagcat ataagacata tatcattcct aaaactccag ctgtatttaa cagagaacct
     4861 attgcccctg taattaaacc tgatatgtat accttatttg tagccttaat tattaactga
     4921 tatacataat aagctaatac acctatcata actcttggta atattgaaac taatggattt
     4981 ataaaaacaa aagatgttac tgttgggttt gttatagcat ttaagagact tgatatccca
     5041 aatataaatc ctattgctgc cccaactatt ggtccttcca taatagctcc aataataact
     5101 ggtatgtgca ttatagttgc ttttgtaggt ccaactggaa taaatcccaa tggagtcata
     5161 gatagcataa tagaaatagc tgatagtact cctattatag tcatctttct tacatttact
     5221 tttcttactg atgcacttgt gttcatcata aaaaatacac ctccgttcca gctcattaag
     5281 atgccggact acttaatttt ttaatttttt tcgttttttt cttataacta tgagtcaagc
     5341 taccattgta ggatgcccgc tctaacaaga ataattttat caagatgagt tgccattgtc
     5401 aacaatttga caagaaaaat atgctaattt catcatattt ctcgtttttt tactatatct
     5461 ttatatgcca ttatattttc tacactatcc gcttttttta ctgcatttat tatacttttt
     5521 tccacaacct ctacagccaa tgaacctact aatgttatat ctgcttctat ttctcctgtt
     5581 gatattgtga atattgtatc tccatcatga ggtgtatgga taggaaaaat agacttagca
     5641 tatccatcat gtcccatttg agatatcttt ttacatccag ctttggttaa cttagcattt
     5701 gttgcaatta tcccaattgt agtattatct acactaaatc cacctttact ttcaccttgt
     5761 ttcattaatt tatatgtatc aattgtttct gtctttttat catttaaagc accagctata
     5821 accttaccat tttcataaac atctccaaga gcatttacag caattaatgc agatacaatt
     5881 agaccattat ctaattttat agaatagcta cctattccgc ctttcatagc atattcctga
     5941 cctcttatct ttccaacagt ggctccacaa cctgctccat aatttccttg atttaaaata
     6001 tcagtatttg caacttcaca agctctataa cccatcttta aatctggtct acatttaaag
     6061 ctccctactc ctaaatcaaa taaaactgct cctacaacta taggcacttt acctacacct
     6121 acatcaaatc caattccttt ttcttctaag tatctactta caccacaagt ggattcaaga
     6181 ccatatgcag aacctccagc caaaactact gcatgaactt tttgaaccat atttacaggg
     6241 tctaataaat cggtttctct agtacctgga gcagagcccc ttacatcaac accgcaagta
     6301 gctccttctt cacatattac tactgtgcac ccagtaagac catttctatc ctcaacctgc
     6361 ccaaccttta agccttctat atccaaaata ttattataca tatccttttt ctcctcttat
     6421 agaaacttca cctgaaataa tttcttttat acttccatca cttctttgaa ctaataaatt
     6481 tccctcttca tttatgtcta aacatttcac tagttctcta ttatctcctt ttaatacata
     6541 tatattttta tctataattg cagaataatc tctacatatt tttaaggttt tttctttgga
     6601 attatttaca gtataatcta aatataattt ttcaaattca gtcaatacat tcctaacaat
     6661 atctactctg gataacatat acccttcttt atacaatgat gtggctttgt cagctatttc
     6721 ttgttcaaaa tccattattt taacatttat tccaattcca agaacaacat aatttgttct
     6781 ttcaatttca gcagataact ctgttaatat accacatatt ttttttccat ttaaaataac
     6841 atcatttggc cattttatta atgtatttgc tcctagattg tttaaagctt tcgttacact
     6901 tgctcctgct attaaagtta taaatggggc tttgaatggt tccatatctg gttttaatat
     6961 aatactcatc cagattcctt catgaggttt tgaatcccat cttcttccca atcgtccttt
     7021 ccccatatct tgatgttcac ttaaaatcac agtcccatct acactattta tagctatcct
     7081 tttagcatgt tcatttgttg aatctatagt gtcaagatgt tcaatatttt ttccaataaa
     7141 ctctgtatct aatttatagt aaatattctg tgggcttaat aaatcagttg gattttccgc
     7201 taatcgatac ccttttttat ttacagattc tatattatat ccctcttctt ttaaggcttt
     7261 catatgtttc catatagctg cacgtgacac ccctaattgt tttgataatt cttctcctga
     7321 aataaattca gatttattat ttaatataat ctctattatt ttatctctca tatttcacct
     7381 ctaatatgac ataatttcat gacttatttt cttctaataa ataattatac attattaata
     7441 tacttttaat actattaatt ttaaatttcc tttttaatta ttataatggt tgttttatat
     7501 tttatattga tgatttatat aattttacat tttatttaaa taattttaaa ataataaaaa
     7561 aactgaaagt atcaattaaa ttaatacatg caaatataat ttgcttatta atttaatatt
     7621 atactttcag ttttagtatt taatccacat cagataataa tcttaaaatg accaaggtct
     7681 taaaactatt tatctttatc agatttatct tctaaatttt tatttatatc aataacattg
     7741 tttctttctt cttcatcttt ttctaatttt atagttaatt gttcttcaac ttctttagaa
     7801 gaattttcct ctgtaactgc attttcaatt tcattcagag gtaactcttt attaaatgct
     7861 tttacaaatt gttctgcatc taaagtttca tatataagta aagcttgtgc tacatactct
     7921 aatctatcca tattttcttg taatatactt cttgtcttat catatgcacc atcaactata
     7981 cgctttgttt cttggtctat ctcaaaagca acttcttcag aataatttct cttacttgaa
     8041 aaactattac ctaggaatac ttcatcatca ctgtcaaatg acattggacc aagtttagaa
     8101 ctcattccat actttgttac catacttctt gcagtagctg taactctttc taagtcattt
     8161 gaagcacctg tagatacatc cttaagtact agctcttctg ctactctacc accaagtaaa
     8221 actacaatat tttctttcat ttcatttttt gtagcataga acttatcttc aacaggaagt
     8281 tgcattgtaa accctccagc tcttcctctt ggaactattg taacttgatg aacaggactt
     8341 acttcttcaa gtacatgggc acaaactgca tgccctcctt catggtatgc tgtaagtctt
     8401 ctttctttct cacttattac tttcgatttt ttagccacac ctgctataac ctttgttata
     8461 gcttcttcta tagtttccat cttaattttc ttttctcttt ttctagctgt taatattgca
     8521 gcctcattca ttaagttctc tatatcagca ggagtaaatc ctggtgttct tctagccaag
     8581 acatccattt ttacatcatc acttaatggt ttatttcttg agtgaacttt aaatatagcc
     8641 tctctacctt ttacatctgg tgtaccaaca acaacttgtc tgtcaaatct tcctggtcta
     8701 agtaaagctg ggtcaagtat atctggtcta tttgtagctg ccatgattat tataccttga
     8761 tttaccccaa atccatccat ttcaactaga agttgattaa gagtttgctc tctttcatca
     8821 tgacctccac caagacctgc acctcttttt ctaccaactg catcaatttc atctatgaat
     8881 atgatagctg gagcactttt cttagcctgt tcaaataaat ctcttactct tgaagcacca
     8941 accccaacaa acatctcaac gaaatcagaa ccacttatac tgaaaaaggg aactcctgct
     9001 tctcctgcaa ctgctcttga tagatatgtt ttaccagttc caggaggtcc taccataagc
     9061 attccttttg gtattcttgc acccaattca atatatttct taggattctt taagaaatct
     9121 actacctcct gcaaatcttc tttttcctca tctagtccag ctacatcttt aaatgtaact
     9181 ctagtttttt catcatcttt atgaacctta gcttttgatt tgccaaaact cataaccttt
     9241 ccgcctccac cttgagactg attcataaac acgaaccaaa taatcaccat gaagaatatt
     9301 aacagtaatg taggcaacat ttcgacaaac caaggtgtag atggcttagc ttcaccacca
     9361 aaagttagtt tcccagcctt agcttggtct aacacctcat ctgcaagttt atttcccatc
     9421 acttctgttg gaacatatga cttaaacttt gtatttgtat cttttatagt accttctaca
     9481 gaagtttgat ttacaaagta taatcttgat atattctcat ctgttaattc tctatatact
     9541 tcagagaatt ttaaatcttt tattttttct gtaggcttac ctgagaattg aactatacct
     9601 actataatta taaaaacaag tagataaaaa cctgcccctt ttagcaactt attcaatata
     9661 gaagccctcc tttcatacat tgctttgccc tataatttgt taaaattaat ttttaatact
     9721 tcttttgtgt tttcatcaat tttataattt tcactgattt tataatctcc aacacatatt
     9781 attccttcac tatctgtgat tataggaatt ttacatcttt cttctcttgg gatttttaaa
     9841 tctatgaata aatctttcac ttttttactt cccatagcaa gctttatctt atcaccttgc
     9901 cttctgcttc ttattactat accccctttt accttattaa aatcaaaccc tttagatgaa
     9961 ttgtctaatt tcatactctt atacctatct atgctcatta cttgggtctc aataatttgt
    10021 tttaattctt ttattttaat aaacccatta ctaggtacat tgtaataaaa ttcaatttcc
    10081 tcattaacaa tttcctcatt cgttaatatt atactgtctt tttttctata aacaaatata
    10141 tttcttggaa gagttaacat tttatttact tttgaattat cttctaaaga cattatatct
    10201 tctatatgtc tttggtcaac aaaattagta tctcctagta tatgttttat ggaatttcta
    10261 agaactctaa ctttgatagc atcatgtaag caaacaaaat cgtctaaatt tatctctaca
    10321 aagccttttt cttttatatt tgaaacttct ctaaatttag cttctgcctc tttctcaata
    10381 taatcgttat cactttttaa actattgctc atcctcacta tagattctat tacatttgaa
    10441 ttaaaattat ccttcatata tggtaaaagg tctaacctta tcttatttct agtgtatata
    10501 ttttctaaat ttgttttatc tatcctcgga tttaaattat aagcttcaca atactcctct
    10561 atctcatttc tttccacgtc taatatgggt ctaattatgc aattatctct aatataatca
    10621 attcccttta agccttttaa acctgttcct ctcatgatac gcatcataac cgtttcggct
    10681 tggtcattga gattatgacc tattgctatt ttattggctt taatcttatc cttaatttca
    10741 taaaacattt catatcttag cttccttgct ccttcttcta atgataatcc ctcattttca
    10801 caatattttg gtacattaat agactttaca aagaatataa ttcccatatc ctcacaaagt
    10861 ttagatacat ataatgcatc tttttgagct tctatccctc ttatttgatg gtttaaatgt
    10921 gctgcatata tttctatatt aaaatctttt tttaatctat ttagtacatg caataaacaa
    10981 actgaatcag gtcctccaga aagacctaaa actattttat cgcctttttg tattaaatta
    11041 tgtttattta tagtacttag taccttatca aatatcatat ttatccctct tacacttagt
    11101 tttattcact tttaagtata ctttctataa aaaaacgcta aacccttgta tcaattttaa
    11161 gaaattaaag tttaatataa atataataat accaaataaa ttaaataaaa ggtagttttt
    11221 tcactacctt tataaaattt ctggaaaata gccatagtta ttatttagta cctatgtata
    11281 tatctatttt attcctacct aaaaataaat cttgtacctt tatattatag tctattttca
    11341 attttatgtg ttccccttct tgtatattta tatctaattc tcttgtatca atatcaatta
    11401 ataaagtacc ttgtggggtc acatactttg tagtactact ttctccacat ttaaacagca
    11461 ttgttgagtt aatagcacca aactttttga tactaacttg atttttaagt atctttatag
    11521 tattagttat ttctatatct tcttcttttt ccttgtaaat aacatatatt ccatcatttt
    11581 tataaaaaat tttaccaaag gcagtcatct ctatggtgtc catatttcct ttttcatcat
    11641 attgtctagt atttatactt atttttacac tcaacgattt ttcctccata gattcttcat
    11701 ataaactagt atttttgtat ttctactttt tgaatcttat caattttttt ctttaagaac
    11761 tctcttgcta tatctgaaaa tttttcaggt atatctgata cataatattg ataagttcca
    11821 tgaatttctg tattgtttat aatattttgc acctctaaaa tcttttttaa atcctttgca
    11881 gtctctttag ctggattaac aagttttata tgctctccaa cttcttcacc tattgttctc
    11941 tttaaaatag gataatgagt acatcctaac actaaagaat ctatattttt ttctttcaat
    12001 tcttgtaaat atatctttgc tgtcagttta gccacttctg tatttgccca tccttcttca
    12061 acaataggca caaataaagg acatgcttta ttaacaattt ctatactctc atctatttta
    12121 gatatttcca agttgtatgc ttttgaactt atagttcctt cagttcctat tattcctaca
    12181 attttgtttt ttgtagaact tacagctgtt ctagctcctg cttctataac tccaattatc
    12241 ggtatatcat atttttcttg agcttctttt aagcttcttg cagtagcagt gttacatgct
    12301 ataactatag cttttacacc ttttgttttt aaaaagttta tagcttgaaa agtatattta
    12361 attatagttt ctttggatct tgaaccatat ggtattctgg cagtatctcc aaagtatatt
    12421 atatcctcat ttggtaatat cttcattatc tcttttagaa ctgttaatcc acctaatccc
    12481 gaatcaaaaa ctcctattgg tttattgttc atctttatac aacacctact ttacattttt
    12541 gtgtttaaca acaacttatt tatcgctaaa atttatattt atattcataa ttaatatatt
    12601 attacctaaa tgattattat agtttatttt acacaaaaaa taaaggagct atcttaaatt
    12661 agaaaataat ttctacaaaa agacaactcc tttcactact taaaaattta aatttatttt
    12721 gcaaacacat gatttcctat tctcatataa ggattcaatc tatttatcca tttgcaagtg
    12781 gctatttctg gattccaaaa atatactgct ttattagttg ggtcagttcc ataaagagct
    12841 tcctgagctg ctttacgtgc tgagtctgtt ggtgccatct ttattgaacc atcaagcaca
    12901 actgagaaag catttttttg atatatgact tcttctattg tgtctggaaa tctagggtcc
    12961 aatactctat ttattactac agctgctaca gcaacctgtc cctcatagct ttctcctcta
    13021 gcttctcctg caaccaactt agataataac atcaagtcat tatcagataa atttattact
    13081 tctttctttg ctatattttt ttcttgtttg tttactttct taatattttc tgttggttca
    13141 tatgcaaata cctctttaat aggcataaat ataaaagtca aagctaatag tgtagccatc
    13201 agtttactcc acctgtccat gattaaaacc actccttaca ttcttatttt taaaattttt
    13261 tctctaaatc cttgactact tcaagtactt taaatttaat ttttactcta cttgtttttt
    13321 ttggtgtatc ttgttttatt aacttatatt ctttatcagt taaaacttcc ttcaacttat
    13381 catctgtaga tttatctatc actccattag attcatcaac aaaacatagt ggagggaaca
    13441 taacacacca ccagtttttt ccttcacctt tcccaatgat aatctttaat gctttatatt
    13501 caccagctgg aagaactata ttagaatatt gtttagtagg gaaattgcta tattgtatac
    13561 ctacctttac actgtaatta tatccatttt taagaataat atttttactt atttcttcca
    13621 aactactata ttcctttttt ataatagctt cactttcttt tatacttttt gaattttgaa
    13681 gctttggctg taaatatttt attacttcat ctctaacttt tagtttaagt tcttggtctt
    13741 catctgtatt gctgtttgct ataacatgaa atcttattaa tttatcttta taatcttttg
    13801 atatattgtc tacttttttt acctcaccat ttattactat tgtcattatt gatatgactg
    13861 atataagact taatattaat agtcccaatc taatcttaat ttttctcatt gaaaattccc
    13921 cctcaagata aatttatatc atcaattatg tccaattaaa tttaatttat tcataatatt
    13981 ttttaatact aataaaaaaa gctatcttaa aatgattaca atcattttaa aatagctttt
    14041 taaaccttat attttataag tctttactaa tcatagcctt atctatcata aactgctctg
    14101 ctttttctat atgctctgta gcatacttct tggatagctc actatcacct ttaattatag
    14161 catcaagtaa atatttatgc tcttcaacaa tattatgtga tgtatcataa gcagacatat
    14221 aggtaactct aaatctatat acttgttccc acaatgagtt tattaattgg attaattttt
    14281 tattattagt tgctttaaat atacattcat gaaattctac atcaagtttt aataacgcat
    14341 ctacatcgga ttccaaagtg ctttttttaa attcttctga tatatcttta agctttttaa
    14401 tatcttcatc actaattctt tcagcggcaa gatatgctgc taagccttct aggcttgctc
    14461 ttacttctaa tacatccata atatccttta atgacatatt tgccacatac gcaccttttc
    14521 taggcaacat aacgactaaa ccttctaatt caagctttct tattgcctct ctcactggag
    14581 tcctacttac tcctaattgt tctgctagtt gcacttccat tagcctttga ccaggcttta
    14641 attttccttc taagattgct tctcttaaat tctcaaagac tacatctctt aatggcttgt
    14701 aattatccaa gttcagttta gttaaattct ccacaaattt caaccccttt ttgactgcta
    14761 ttaacaacat acacctgttt atattttttt aataattctt tttttccaat tagagcatct
    14821 tctttatttt taaatagtcc aaaaactgta ggaccacttc cactcatcat agaacctaaa
    14881 gcattatttt tcatcattac ttgttttata tcacttattt ctttgtgttt acctatagta
    14941 acattttcaa gaatatttac catgctttct gatacagctt ttatatcttc agattttaaa
    15001 cactctatca aatatttatt atttggtctt tttttaatat tattcaaatc taatccttga
    15061 taaacttctt tagtagaaac gaataagtct ggtttgcata tcaatatatt tgtatcacat
    15121 ggtaaacctt tgatgtttgt tagcttttct ccaatacctt gagctaaggc aggtcttcct
    15181 gatatacaaa aaggaacatc tgcgcccaaa ttaagtccta tttcttttaa ttcatcttca
    15241 gataatctaa gttcccatag gtgatttaaa cctactaata ctgcggctgc attagaactt
    15301 cctccagcca tccctgctgc tacaggaata tttttttcta tgaatatttc tacacctttt
    15361 tttatataaa atttattttt aagtattttg gcagctttat aaacaatatt atcttcatct
    15421 aaaggaatat ctaaactagt gctttttacc tttatttcat cttcgtctaa ttcttttatc
    15481 tttactatat cgtataaatc tatcgtttgc attatcattt caacaaaatg ataaccgtct
    15541 tgcctttttc ccaagacatc aatggataaa tttatttttg ctctactctt tagtcttata
    15601 aaatccattc tatcctcctt gtttaaagaa taatgcatca ctaacaataa tattatacta
    15661 caaaaaataa aataataggg tattataata ccctattata cttaattact ttaaattttt
    15721 taatattaat ctactaatac gacttttttt tctaaaataa gacacttacc aggcttaatt
    15781 ggttcatcaa gttttatatc attaagttct gcaatttcat tttctgttgt attgtatttt
    15841 tttgctatat tccagaaagt atctccttct ttgcatatat atacgattat gctaggagct
    15901 ttagataaat catatacacc ttggtcttct cccttgataa taaaattttc tgctttctta
    15961 tctaatgctt cagtaaatct cttaattttg ataatcaagt ctatctggtc cctattcaaa
    16021 tcaacttcga ctttatcaat acatgctgta ttaaacacag atgctgtatc agttagatta
    16081 tccatttcta tatcatgttc aaatggaatt tcctcactaa ttttataaac caattttaaa
    16141 ccttcaactg ggacaaataa aatttcaact tttatgattc cttgtataat gcttttattt
    16201 ccttcaatat aactattttc tatagacatg gttggacaaa cgcttacaat atcttttatt
    16261 tgtatatcat cattatcatt tcttatgcct tctctaacca taaatgtttc ttcactacgt
    16321 cttaaagtct tatttaattg aataggtttg tggtcaaatt ttattatctt ttgaggcgaa
    16381 tatgcatctt gtaatacttc tcttgtaact tcatctgtaa cttttacctt acaacaagcc
    16441 atacaatcta tttctaaaag acctgtgttg ctttcactat tttgcttgaa aatatgatta
    16501 aaatctgaca tagacaacaa tacttcttca gtcataccat cactaactcc agggacttct
    16561 acaaattgag taaactcaat acctactcta tccaactcta caagttcacc ctcatatgta
    16621 caagctaacg gatttatttc taatactcca ccaataataa ctttattgtc agtcactcta
    16681 ctttctttta ctttaacaca tggatttaaa cttattatag attgaatttc ctctgtgttt
    16741 attgttatag tatctcttat agaactttct gctttttcta ttccaactat atcttgaaaa
    16801 caaatttcct ttctgtgctt ttgtatgcct tccacttgcg ccacatcttt tacaatgtct
    16861 aacctttgct tttcaaacaa acttcccctt atattcataa gagctcctac tttaatcttt
    16921 ctctcattca ttatagtaca atccatatgc tctacttctg aaaataacat gtattccata
    16981 tcttgaacaa cattgtcttt ttctattact tcgtttatat ctacttttcc gtctacatta
    17041 gaaatagtat ttttatcatc tgcaatatag attacattat aattaaaact acctctgcaa
    17101 agtatcttcc catctgccat ttcaattttt ttaagtgata tgtatccttc tgtttttaca
    17161 atttcatata catctaattt tttgtctggt acaactgcct ccgcttcaat gaatgtttga
    17221 aattttccaa agtctattct attgtcaact ttaattacat ctttaattaa ttccatagtc
    17281 tacctcctta agtattataa aaatatcaca ctatatttat atttaaggag caaaaaaaaa
    17341 attacaccta tttttaaata ggtataattt taacttattt gtaatttatc ttgatctcta
    17401 aaaacttgca actttacatt agatgttaat aaatctgagt aactataaga tactctagga
    17461 tatccattac tttcatcatc taactttata acaaacacgc ttggataaac tttttctagt
    17521 ataccctctt ttgtaataat ctgctttctt cctttattag ctttcaacaa tattttcttt
    17581 cctatatgtc tctctaagct tactcttatc ttatctagag tttgaacagt agccacaata
    17641 tcaccttctt taacgtttat atgtttacat aatatcacat ataaacattt ttgtcaaatg
    17701 tttaaactaa ttattttata tattttttgc aaaaatgtca atactatttt tgaagatata
    17761 cagtataatt atgttaattt ttgctaatgt aatattgttt ttggcattgc ccatctaaat
    17821 tttcctctgg tttcagaacc accaattccc ttaacacctg taatagtctg ctctataacc
    17881 tcatcaatag gaactactac atcaattctt gaacaagcaa ttttctccac tataaaaaca
    17941 gggtctaatg catgtatcat tatccttcca ggcgaacttg catagtttgc tcctgcactt
    18001 attatttttt cataatttga ttggcatgct cctgcgaata tgacaagatt atccaaattt
    18061 ggttgccatt tacgtgcttc ttttactgtt ttaacaaaat ttgaagagtt tctatagtta
    18121 ctcatatctt ctatatctcc tctttttatt gtcattgcat catgacctgt tattactagt
    18181 atatccggat tatatttttc tagtagtgct cttacttctt tatactgatt ttgctctgaa
    18241 acagctacac ctactgcagg tattccaagt tgagcatata catccaagca aatttttaaa
    18301 tattctttat ctccatctat ctgtagtact tttccaggca ttccatatgt gttaggattt
    18361 aattgaagtt ttggaactgc tctagtcatt cttttttgtc tttctttagc ttttcttact
    18421 gacttatata ataaattttc tacattttta tctattaata tatcttttat atcaggtgct
    18481 tttactaatt ctaggtcatc aatataagca tctgctatta ctctaaatgc aattcccttt
    18541 agtatagcta ttttctcatt attttcatct acaccaaaag agactatttt aaatactata
    18601 tctttgttat gtgactttct agctacaatg tctcctacct tcatagttaa acctccaata
    18661 aatttttatc ttagtttata ctatgttcga tataaaactt tgtttcctaa tgtcaaaaaa
    18721 acatttctta taatacttct tttatcactc ttaaagcatt tttatagtat atcttttcta
    18781 tatcatcttc actaaaccct tcttttttta gaggttcata cagtttaccc atctgagata
    18841 tatcttcaat ctcaactttt gaatctattc catcaaaatc tgaccctaga gatacaacat
    18901 ctattcctcc aacatttaca atatgtttta tgtgtctaac catatcttca agtttacttt
    18961 cacttttatc acttaaaaat aagtggaaga agtttatacc tgtaactcca cctttatttg
    19021 ctaatacttt aatcatatca tcagttaaat ttctagaatg attcatcatt gctcttgaat
    19081 tagaatgtgt agcaattatt ggtttagaag aaatctttgc aatttcataa aatccaccat
    19141 ctgaaatatg agaaacatca accaacattc ccaattcatt catcttatgt accacttctc
    19201 ttccaaaatc agtaagccct ttttctctat attctacttt attatgagga aagctcaatt
    19261 cattcacatg attccaactt attgtcatca ttctaacccc taagtcgtaa aatttcttta
    19321 aattttctaa tttaccttca agtactgcac cttcctcaat agataaaaga gctgtaagtt
    19381 taccttctga ttggtttttc ataatttctt catagttagt agctaaagct atttcatcac
    19441 tatttttttt catttcctca tgaaatttat ttgccatact catgcaataa tcaaaaggat
    19501 gttttacttc ttcagtatca acaaaaagag caaatgtttg agctaatgaa tccccctttt
    19561 tcaatctgtc tatatcaaca gaatatttat tagacttaag ttcacttgtt tctacatttt
    19621 ccattaattt tgctatagta tcacaatgta aatcaataaa tttcatattt ataccccctg
    19681 tatattttat atttatatct aaaaatagaa atagttgtcc ttatagacaa ctattgacaa
    19741 ctatttttta atattctttt taatattact taatcttatt cttcttttaa gttaggtatt
    19801 acttttttaa cttcttcaat ttgatgccat gttttatcta tattattttc actaatatat
    19861 ttttttaaat cagttaaaga tgtaaaatct ttaactgata aattgtcatc atcatctgca
    19921 aatcttaaaa taaacatgag actcccttac tttccacaac atttcttata tttttttccg
    19981 cttccacatg ggcatgaatc atttcttcct atttttgctt ctttaactat tgttttagac
    20041 ttcttataag cctttattat ttcttttctt tggtctgctg gtagtatatc ttcccaacct
    20101 tgtaaattat atagccaatg agcctcaaca gttaccatat tgttatataa tttttcccaa
    20161 tctattttta tagaaacttc tttatcagct tctacttctt ctaaaactat atcttctttt
    20221 aagctttcac ttattccatc tatgaatccc atgaaaaatt cattagtagt tccaaatttt
    20281 tcagccaatt cacttacttt accttcaaca acatccattt tattatttaa tatttcattg
    20341 tatattccag cttcaacttt caaatattct tcccagaatt ttacttctgc ttcttgactt
    20401 tcatgattat cacttaaatt tctccattca gtatataaac tcatactttt tcctcctaag
    20461 tatacctata tttttatagt ttttatagta taaaatcttt tagttagatt ggaagtttct
    20521 tctttttgat tataccatat tctatttaaa gttaactctt atattatatc ataattaaac
    20581 aattctttta atacttttat agcatactct tggtttataa aataagggct tgtcgcaatt
    20641 gttattactt tggctttttt aattaagttt tttatcttgt aaaatttgag ttcaaatggt
    20701 atatagtcca tatcacttga aaatatatcc aaatctatgt caagaacaaa ctctgattct
    20761 acttctaaat caaatccata tagactatct attattatta attctgaaaa tatgttatat
    20821 tttaaagcag gttttataaa acttcccaca tttaaaactt catttgtata tctaaataca
    20881 tcttttagat tatttacatc tacatcatag ttctcaggtt ctctagtatc cttatgttgg
    20941 tctacatgca ctaacttgca tccttttgta aactcaccct ttaacaaaga ctttgcccaa
    21001 aaataaaatg catggttatg attgtcaaac acatatatct ttttatttcc caggacatat
    21061 tcgaccatat tctccaatcc ttttgctttt atttccttat tttcatctac ttcattaaat
    21121 actacctcat tgcctaacct tacatcattt aatgtaccat ttataagttt tggaacgtat
    21181 atgctcttat tttctctttt atcatatgaa aatacattat ttcctactgg tttttctata
    21241 taaaatccac tatattcata attttccata aaactttatt tcctccattg ttatataaat
    21301 atataagtta taattttaaa aattaaaatg cacttattgt aaatcatatc atctattata
    21361 gaaaacatct tatataacta aatataatat cttctctcaa tatgtattat acaataagtg
    21421 taaaatatat ttatataaaa tatactacat tcctataaca aaaccatcag cttcaattgg
    21481 aagataacta actcttctat tcaactccac ctttccaaaa aatactaccc aatatggtct
    21541 aaaaatactt tcaattttaa ctatttcaat ctctgggatt cctcccataa acctatgagt
    21601 taatctcata gccattttat ttgcctttgc ttttactctt cgttcgtcct tatcactata
    21661 ctgcacaata ttacaatcca cattttttac aacttcatat gtaggaaaat cttgtactat
    21721 actaccagaa cctgtagaac cattcactaa aatttttaat tcatttatat cattagaata
    21781 tctcctattc ttgaaaatgg atttcgtttt gtgaatttta agtgtgataa ttttaaactc
    21841 tatataatga agtctaactt catgagcata tttgttcttt aatattagct tactaaataa
    21901 agaatttttt ccacttttag ctatctctat agcttcttct tttgtaattc ttataggtaa
    21961 cgctcttata tccataaaat cattctcttt cttatttttt tcttgtcatt tttaaaactc
    22021 tatatatata atcaaaaaat attacaatta caactgacat aactccatat ggaattattt
    22081 ttccaactat aatatcattt ctagtcaata taccataaaa tataaatcct gttattaaaa
    22141 agtacaataa tactagaaaa ccgtctattc caagccattt tatttctaaa tcttttttta
    22201 ccttagacac taatttagac atagcagttt ctccttttat agattatttt gtgtatttaa
    22261 attttcacct attctattac caatcatcca tgcaataaat gaaaaaggta tagctatcac
    22321 aagaggctct aactcaaagc tctgaactgg aaatatttta aaataaccaa aagtcactcc
    22381 accaacaatc attcctaaaa taccacccat agatgttctt cttccatttc caagaagccc
    22441 acctactata ggtacaaatg ccgaacccat ccaaatactt cctacaaata tacatgcatc
    22501 atatacattt tcaaatctaa atgctacgct aagccccata actgctgcta aacatacacc
    22561 tattctagta aactttacta attgtttctg agataactct ttttttgtaa ttcttccata
    22621 tatatcattt gctaatgtag ccccagctgc tagataatag ctatccaatg ttgatattat
    22681 agaacctaaa attcctatta taaatattac tcttattcct tgtggtaatg tatctaaaac
    22741 taaagttata tatccagcag ctggagccat ttctggataa gtagctctta ctataagtcc
    22801 tgtcatagtt aacaccatgt caaaacatat ccatagtgaa aaacaggtta ataaggctct
    22861 tcttccaacc ttaggagaat ctgctgctga aaatctttga taaaaagttg ggtctgaata
    22921 agctccaaaa gaatatacaa ttaacatcaa tgctttcata gctgacatac cctttgtagg
    22981 gtgcataagc tgtggtgcat ctttgagtgc ttctgtaaga ccttgaaacc ctcctatttg
    23041 ttcaaattga cctggcataa ccatagttaa accaaatacc atacaaaaaa acaataccat
    23101 atctgtaatg gcaactccca taagcccacc aagtactgta agtacaacga ctactcctac
    23161 cattattaat cctattaatt ctttatctat tttccatgct acgttaccta tagttcccat
    23221 agcagttatt tctccaagtt gtgcacaata tataaacatc aaaattgccc caattatagc
    23281 aacatgcttg ccataaaaac tttccagtaa atcaggaact gttatattgg ttcttatatg
    23341 aatccttgga ccaacccaca atgctaaagg cattctccca atatgtgcag ctattgacca
    23401 aactgcccat gcagatattc catatatagc cgcatactct acactaccta ctgtaccaac
    23461 tcctccatac catgatgcaa ccaaagttcc tactattaag gaccatggta aacttcgatt
    23521 tcctaggtaa taactttcca tatcttttac atttctagaa aaataataac ctattcctaa
    23581 taatataaat gcaaatataa ctataatccc attttcccaa aatgttaaca tatctaatct
    23641 ccacattctt atattttaat ttttaacttt aatatctaaa tatgaacaac tctacccatt
    23701 tccataaaaa taggtagagt tatataataa ttataagtat ttaagtaatc ttgttattaa
    23761 gcaattttat tgtttaaacc tttattttct cttttattta ttttatttaa agcataagta
    23821 gcaaatatcc ctataactgc acatactaca gataaaataa atatatatgt atatcctgtt
    23881 tgtccatatt tatctaacca attacctgca atagtgtaat aaaacgcatc tggagaaaat
    23941 cctataaatg aagcaaatcc aactactgct cctgtagttt ctaaagatat attagactct
    24001 gaaacagatg caaagtatat acctctaaat ccaaataaaa ttacacttag tattatcatg
    24061 tttattacag ctatccatat aaatcctgta ctcttaggaa taaccaagta agcagctgta
    24121 cttactgtca ttaatataaa tcctacaaac attactctta tagatgaacc aactttatct
    24181 gttataacac cagcaactgg agatgctccc atttttataa cataagttct tattattgat
    24241 aaagcagaaa ctagagtcat tggcattaca taaacttctg ataagtatgg acttaaataa
    24301 gttaaacttg agaatactaa ataagttgaa aatattataa gaccaattag ccaagccttt
    24361 ggcattgtaa ctacttttaa caatgactta atacttaatc cttcatctga tgctccacta
    24421 tcttttttct cttccactaa gaaaaataga agtataccac atattataga tgctgcagaa
    24481 tataaccata ctacatattt gaatcctact gttatttcag caaatttacc aaagaagtaa
    24541 agacctataa aagaaattaa tgtacctgat acacctgata acccttcata aaaaccaaat
    24601 attcttcctt gctctgactc acttccttgc attctaacaa ccttaacaga ggctgagaag
    24661 aaagttaata ttgttgtaaa tccccataat acaaatatta aaagtatcat actatatgat
    24721 gggaatgtag agaaataaaa tccaagtatt cctgaagcaa ttaaagaaaa agttattaat
    24781 tttctaactg agaatctatc tgcaaaccat cctcctataa aataagatac cattcctact
    24841 aatccatata aactcaataa gttccctatt tgtgtatgac ttaatgctaa agcttgttgc
    24901 attgggtcat aaaatgatga tttcatatat ggtaaactat acatagctgt tgttccaaat
    24961 gccaatatga atattatcaa aaatctttta acattatttt tgctttccat tgattctctc
    25021 tccttaaaat tttattgttt ataatctcat tcatataatt ttattttaat ttttctattg
    25081 cttgtttaaa atcatttatt atatcatttg aagattctaa tcctacagct attcttatta
    25141 gattttcccc attcatttga actaatgtat gctcttcccc taagcttgtt gctattgttg
    25201 caagctctaa agaattcatt aatcttctac tagcttggtc tcttgtcaat ccattgatac
    25261 catccttaag tttaaatgaa actacacctc cacctaaacc attcatttga gttttacaaa
    25321 gctcatattg aggatgagat tttaatgctg gatactttac caattccaca ttctcttctt
    25381 cctctaaaaa ttctgctact gctaatccat tttcacaatg ctttttcatc ctcatatcta
    25441 acgttttcat accccttaaa atcatccatg cactcattgg tggtaaagat gctcctgtaa
    25501 aacaacataa acttggccat ctaactaaat ctattaattc ttttgaacct gctactgctc
    25561 cccctaaagt atccccatgt ccatttataa acttagtaag actatgtatt actaaatctg
    25621 cacctaaatc tattggtctt tgtacaattg gtgtcccaaa agtactatca actatagcta
    25681 agcttttatt ttcatgagca atttctgcta ttgtttttat atctactaag tctaatgatg
    25741 gatttaaagg actttctata taaactattt tagtatttgg tctcattgct tcttttacat
    25801 tttgtggatt tactgcatct acaaatgtaa cttcaactcc aaatttagat aacaactcag
    25861 acatgaataa tttagtgtgt gaaaatattc catctgaact aactatatgg tcaccacttt
    25921 ttaccaatgc taatatagta gatgttattg cccccatccc tgatgtacta gatatggcac
    25981 tttctgcatt ttcaagcata gccaacttag cttctaactc tgtaagagta ggattacact
    26041 ctcttgtata cacatatccc catgtcatac acaactcttc aaaatgctct actgtctttg
    26101 cagcaaatgt tgctgtttga catattggtg tagccaatgc acctgttgtt gggtctgcac
    26161 tatgtcccca atgtattatt tttgtctcta aatcttgatt aatattgtta ctcattttga
    26221 tttcctccca ttttgactta tttatacaac gttttcccta ccaaatttca tcaatttagc
    26281 ttagtcttaa tacatttttt caagtatact tttttatttg ttataatttc taaaaatatg
    26341 acacttattt tgttttttta cagttctaat tataaactct atagtaacta tagagtcaat
    26401 atgtttttga tatttttttt acaatgttta aaatagtcag tacaaaaata ggtatatctt
    26461 agaataacta aagtcatcct aagatatacc tatttttata tcacaatata aataattaca
    26521 tataagcatt agttttttta tcataaatag atttttcaag atttatcatc ttttcataaa
    26581 tatattatag ttaaatattt taatattacc taacatctac aataaaatat actcttaaaa
    26641 taaaattata taattaaaaa tactctataa aagctaaaaa gtttttctat tcgctacatc
    26701 taaaaataat tagatagagg tataaatgta tttagtttat ttatacctct agtcttttat
    26761 aaattatatc tctactaaat tgatttttta gcacgaataa gtgtgctctt ggagatacca
    26821 gtcatcttca caacctctct atatggctta gaatttaata accccaatgc atattgtatc
    26881 tgttgattgc tgtatttctt tggcctacca tctttaaagt cctttttctt tttagcaaat
    26941 tcttttccta attgagtacg ttctattatc atatttctct caagttctgc aactgcaagt
    27001 aatgtagtca aaaagaattt acccattgaa gtattttcta aaaggcctat atttaaaata
    27061 tgaacactta cttctttagc aaataaacct tctattagtt gtattccttc tgatgtactt
    27121 ctagctagtc tatccagctt agttgcaaca agtaagtctc ccttttttag agatgatata
    27181 attttttcaa atttaggcct gtttgtagta gtgcctgtat aagtttcctt tattatttta
    27241 gcatcattat atttattcaa aatttcttgc tgttgctgat acaaactgtt gttgtctgtt
    27301 tgattttttg tacttacacg gcaatatcca tatataataa tcatcacttc ctaacataaa
    27361 gattttgtac agaagttacc cagaagcttg tttttactta tctttatcca ttttactaaa
    27421 acgatttttg ggtgtcaata ctgttaactt ttgacaccat aataattcct ttataatttg
    27481 tttgactatg tcaaaaatta ccaatataat gaaattaatg agtttataca aattggagga
    27541 aataatatga atagtctgtt aaaagaagca atagatgaat taaaaaacat ccattgcggg
    27601 gaagtttttt tattaaaaga attgttcaaa ggctatgaat ggaacaggtt ggagatgaat
    27661 atcagattga aattaggaaa actttttttg tatgaagtgg taactaatcc caatttaaat
    27721 gtagaggtca tcaataaaaa ttctgcttat cagcaaatgt ataaaaaaaa atagtgactt
    27781 aaatgtatat aatagtataa tcttcttatt gattcaaaag ttaaaacttt taatacaaaa
    27841 caatcattct attttaacat ttatcaatat gtctaaattt atataattaa cacatacgaa
    27901 tagtattgtt taaatcacat tatttaagat agataaatct taaccctact ccagcataaa
    27961 tactaaaata gggcttagaa ttatctatat ttttatccca taaaatgctt agctcttcct
    28021 cttgattgaa catatatatc tggggaaata caatagaagc gtaaatttat aaaatttcca
    28081 aagtcagaaa acttcagttc aaacttaggt ataccaaaac tttcaggtgc tatttcgtca
    28141 acgccaaaat agatgataat tccattatct gtaagataaa atgcttggtc ttcaggtata
    28201 actaactcaa cattagaata atacatttct ctattttcat ttatttgaga tttaatgtaa
    28261 tcagtaatta tattaatata atcaactcca tctctaaaaa tgtcattaag taaaagttct
    28321 tttccagttg tcaaatctat attgtaatta ttcaatgtat tgtatttagg cccatagtta
    28381 ttagcaaacc ccataaggtt taatatcata ctcagtacat aatttttatt aaaagtaact
    28441 gcgtaactgg tagataccca atagctttgt tttggaagtg aattttgaga agttgcgtta
    28501 ttatattctc gttcttcttc ctgtaagcca tttttaaaat tatttacagt cattcttaca
    28561 gcattgttta tgttatttaa aataactggg tttacatacg tggattgatt tctaatattg
    28621 tatataacag gatactttac atcatatgaa aaatacttac ttctttcaaa atcttcatta
    28681 aattgtacat ataatatatt atatgtacag gtatttgtag attgataatt ttccattaaa
    28741 atcctccccc ttttataaaa aaatcagata caatataata tgcttaaaac agtaataatg
    28801 ttaatggtaa atgtaaagaa tagaaagtat ctaaaacagc aaaaaatgac taattttgtg
    28861 gtataataca taggattgag agttatttta taggaggaaa aatatgttat tattagcaga
    28921 taaatggaaa gattatgaac ttatagatat gggaaatgga gaaaaattag aacgttgggg
    28981 aagttatgta cttagaagac cagacccaca ggttgtatgg ccaatggaat ctgaatgggc
    29041 tttatggaaa aaccctcatg gacattatca cagaagcaat aaaggtggag gtcaatggga
    29101 acacaaaaaa agatatccag aacaatggac tataaattat aaaaacttaa agtttcacat
    29161 taaaccaact ggctttaaac atactggatt attcccagag caagcagcta actgggattg
    29221 gatgatagag aaaataaaga aagctaacag acctataaaa gtgttgaatc tttttgcata
    29281 tacaggtgga gctactgtag catgtgcatc tgctggtgca gaagtatgtc atgttgatgc
    29341 tgcaaaaggt atggttaatt gggcaaaaga aaatatagaa ttatcaggtc ttaaaaatca
    29401 aacagtaaga tttatagtgg atgatgttgt aaagtttgtt gaaagagaaa taagaagagg
    29461 taaaaaatat gatgcaataa taatggaccc tccttcttat ggaagaggtc ctaaaggaga
    29521 agtatggcaa atagaagaaa agttatacag ttttgtagat ttatgtatgg gagttttatc
    29581 agataaccct ttatttttct taattaattc ttatacaaca ggattttctc caatagttct
    29641 tgaaaatgta ttgtctacaa caataggtaa aaagacaaat acaggagata tatacggtgg
    29701 ggaattagga ataccagctt ccagagatgg taagatactt ccttgtggta tatttggaag
    29761 atgggagaaa aaataatgat aaaagtcata tatgaagata accatttatt agttgtagaa
    29821 aaaccagtta acatattgtc tcaaggagat aatactaatg ataaagatat ggtaaatctt
    29881 ttaaaagact atattaaaaa aaagtataac aaacctggaa atgtatatat tggtttaata
    29941 catagattgg atagaccagt aggtggagtt atggtgtttg caaaaacatc aaaagcagca
    30001 tctagattgt ctgagcaggt aagaagtaag actttcaaaa aaacttatct agctgttgtt
    30061 catggcaaga taaaatctaa ctcagatata ctaaaagatt ttttatataa aaataaaaaa
    30121 actaatatgg taactgtagt gaaaaaaagc cataaagatg ccaaagaagc tgaacttaac
    30181 tataatgtat tagattttaa agaaaatcta agtttagttc aagttaattt aaagactggt
    30241 cgttctcatc aaataagagt tcaatttgca agcagaaaac atccattata cggagaccaa
    30301 agatatggca aagaaataaa taagattgga caacaaatat ctctttggtc caataagata
    30361 gaaatttgcc atcctactac aaaagaaaaa atggaattta catgtcatcc acctgacaaa
    30421 tatccatgga atatatttta aatctcaaat gaggtgatta tatgagtaaa aaattttcaa
    30481 taggagaaat gtctaaactt cataaaataa gcatacagac actaaggtac tatgaccaaa
    30541 tagatttatt taaacctgtt catgttgacc aagaaagcaa ttacagatat tactcaattg
    30601 accaattttc acaattagat attataaaat atttaaaata tttaggtatg cctttaaaag
    30661 aaattaagtc aaagcttgat gaaaataatg aagaaattct aaaattacta acaaataaaa
    30721 ttaatatagt ggatgaaaaa attaaagaat tagagcttat aaagaaggta ctaagcacaa
    30781 agaaagaaac tatggaaaaa ggtatgaaag tagatgaagt tggtaaaata gtgagaaaac
    30841 atattccacg aagaagtatc ttatctatag agtatgaaga aggattaagt agtgaagaaa
    30901 ctatggaact ttccagaaga caaatagcaa atatattaga agataatata tctgtgttct
    30961 atggtggagt aagtggactt gtatctatag ataaattttt aaaagaagat aaagttattt
    31021 atgacaatag ttttgttact gttgaaagag acttatttga tataaaatca caaaaacata
    31081 taacagaaat ttcatctggt gattttattt gtatgacata taaagggcct tacaaagaaa
    31141 attataccgc ttttaagaaa ctggttgatt atgttgaata taaaagaata cctattgaaa
    31201 attatatata tgaaatacct ataatagacc ctctgtctac aaacaacgaa gaggaacttc
    31261 taacagaaat tcaaatacaa gttaaaaaga gagaaattga cttaagatgt ctagtgtagt
    31321 aatctagttt acttacacat cttaatatag ttgtctatta tcaacatatg atttttctag
    31381 atagtgattc ctaacagtga gattttcaaa aaataggagg aaatatggct aatgctaatt
    31441 ccctcctatt tttaattaag ccatatcatt ttaattaagc catgtcatca cgaagtgcat
    31501 caataatatt ttcttttttt atcttattaa tagtatacaa cattgtaata aatactataa
    31561 ataaaacact aaatatacta attccaatac taaaccatgg aatcacaaaa tcaatatcat
    31621 ctgtaaccat tactttatga attagccatg aagaaattac tgctatagga agtccaaaga
    31681 acaatgctct catgccataa aaggcacact caaaattcat catcttttgg aaatcatgct
    31741 cagacattcc tacagagcga agcatggcaa gttctctacg acgtaactta atattagttg
    31801 aaattgtatt aaacacattg gcaatcgaaa tcagagaaat cataattatg aaagtataag
    31861 caaaaacatt ggcaataaaa atgtaattac ggttctcatc catcattcca tacatattgt
    31921 acagattgta ctcattcgta actccctcac tctcaataat ttgctccatt tctgcaactg
    31981 actgagtagg atttttcgat tgaaagctta aactttcaat tcctgtagaa acaccaggaa
    32041 tctcaaactt atctttggct gaataaggag ccaatactct gaagcttgct ttcttcacat
    32101 ctgaacttct gattcctgga ggagaatcag gtggcactac tttgacaaat gaaatattca
    32161 cattttgtct ctcaggtatc tccaacttgc cattagtttc aggagtgagg ctaacattca
    32221 tagaagaact gttgaaaata tcaataatat tattatcctt tgttaccata gaaacagcaa
    32281 tcagttttgc attttgtcca gtatattctt ctgctggtaa tccaagactt ttaataatat
    32341 tcagataagt tctatcatca agaaattgca tatctactgg taattcaagc atttcactca
    32401 tagaatgtga accctcatag ttcaaataat cgtctgtaag ctcacttact ttggcaacac
    32461 atgaataggt cataagtttc tgatacaaac cttcgtaaac accatttgca gtttttagct
    32521 tatcgtaaag cttcaacatt tcgttgtctt tcataccttg tgtagaaaaa ataatatcct
    32581 ggtcagtaac ctctgacctc tgatttgaca tctgttttag gtctgctact aaagcacttg
    32641 tagatataaa tagaactatg cttaaaacaa gcgacaatac aatacttcga taacgtttct
    32701 tgtttctttt aaagtttttc atagcaagaa ctccctcaag accataaact cgctgtgtta
    32761 gttttgatgt cttcacagat ttagattcaa tttttacctc atttgtctga cgaatacact
    32821 ccatcactgg tgtgttggca gcctttcttg ctggtatgta agcagaaatt aagattgtaa
    32881 ccatacttac cactgctgca acgatgattg cagggataga caatgttaat gtcaacggaa
    32941 cgtttacata gagaatattt gcaaagtttt tagctatgac agaaatcaca agtccaatac
    33001 tgactatacc gattgcaaca ccaattggta taccaatcgc accaatgcaa attccttcaa
    33061 atagcaccga atttcgtaac tgttttgctg tagctccaac agatgaaagt attccaaatt
    33121 gatgtgttcg ctcgttcaat gacatgttaa atgaattata tattagaaaa attgagccta
    33181 gcatgattat ggcaagcaca atgccaccaa ccgagtacaa aaacatattg aacaaattgt
    33241 tatcagaaac acctatgaag cgcaacacat tgtcattgaa aatggaagca tggtctttag
    33301 tgctacttat gtaagagcga atctgatgtg gatttttcaa tgtgacaaaa aggctaagac
    33361 tgtcagtctt gacttgttta tcttctttgg ttatcaaggt atatcctggt gcagaagatt
    33421 cttcaaatac gggctttcta cagataccca caactgtata agttttctta tcctgtggca
    33481 caaaaacttc actcccagca gtgtatgggt cactctgacc aagcttttca ttttcactca
    33541 ttcgtttccc tacatccaaa gaaatagtat cacctactgc aaatttgaca ccaccatctg
    33601 tcgcaacttt acttgaaaca agaatctctc tactattttc aggtaatctt ccagaaatta
    33661 aagttatagg caaagtatca aaagcttctt tgctaaatcc agcaataaaa agatatggtt
    33721 tatctggatt tctgttacct tcaagtgttg catagccaat attttcaaat gttgcagtat
    33781 ttgcaacttc atcattgact ctttgttcct gtacaaaaga agaatccaca tccaaaaact
    33841 ggacatgcca atcaccatat tttataatag ctccatttgt catatagttc atcaaagaaa
    33901 ctccaaaggt agtaactgct gtaatcatag cagctgacag aacaactcct ataattgtta
    33961 caagagttcg agtgcgattc tttttcaatc cttgcagagc aactttgtta aaaatgttca
    34021 ttaacgattc accttcctct catcacgcac tacttttcca tctgaaatac agataattct
    34081 atctgcctgt aaagcaatgt tttcatcatg tgtgacaata atgagagttt ggtgatattt
    34141 actatggctc tctttcagta actggataat ctcttgtcca tttttactgt ctaagctacc
    34201 tgtaggctca tcagcaagca taactgctgg tgcattcatc aatgcacgac caatggcaac
    34261 acgttgctgt tggccaccag aaagttgatt tggtaaatgt gtttttcgtt cttttaaacc
    34321 aagcaattct aacaagtcat ttaaccgttc ttgattgacc ttacgcttat ccataagtat
    34381 aggcaatgtg atattttcta ctacatttaa tgtgggtatc agattgtgaa actgataaat
    34441 caatccaact tgtcgcctac gaaaaatagc aagtttttca ttgctttggc catatacatc
    34501 ttgcccctcc agatatatct ttccacttgt tggtacgtct actcctgcaa tggaatgtag
    34561 tagtgtagat ttaccagaac cagaagaacc aatgattgca gtaaactctc ctttttcaat
    34621 agtaagtgag acatggtcaa gtgcagtaac cttattttca ttcttaccat aaaccttaca
    34681 taaatcttca atctttaaaa acgccattat ataagtctcc tttcatattt tataaatata
    34741 tcataggact ttcaacttac atttaagtga catttaaatg agagattcgt cactttggaa
    34801 aacgaataac aaatattgca ccaccttgtg ggtgattttg tgcagtaatt gttcctcctt
    34861 gtctcataat aatcgtctta caaagtgcca atcctattcc ataaccggct gtgcttgaat
    34921 ttttcccacg ataaaatctg ttaaatagac atggtaaatc ttctttttta aagcctgctc
    34981 cgttgtcatg aatagtaagt tgagtaaaca aaaagttgtc ctcacaaatg atatcaattt
    35041 ttccattatc acccacactc tccatgcagt ttttaaatat attttgaatt gcttctgaaa
    35101 gccaatttaa atcacccaaa atccttactc cttttggtat atcaatatgt aaagtgatat
    35161 tgtgcagttc catgggaatc aaaagttgat gaagtgcaga actaatcaaa ttattcacat
    35221 caatttgttc tttttgaaag actacaatac ctgcatctaa acgtgataat tttaaaaggg
    35281 aagtaatcag ccagtccatt cgtataagta attcctctgt ttctcgtatc aactcttttc
    35341 tctcatcttc atcagaagta ttctctaaca gtgacaaaat aagagttact gatgtaagag
    35401 gagtgcgaag ctggtgggct atgtcagcta gtgagtcagc aaggtgttct ttttcttttt
    35461 tcaatgcgta attttgctct ctaatacgta acgtcatttt agttatttca ctttgcagaa
    35521 tagaaagttc accctcatct gattcagcaa tatacagatg gttagcatta tgaagcacaa
    35581 gattaatttg ttctgaaatc tgtgcaatac ttttgtatcg atttttagta aacacaaaaa
    35641 atgctattcc aaaggtagtg gcagaaacaa tagaaagtat tccagtcata atactgattg
    35701 caaatcccag ggctacagtg agaatagtaa ttaataagaa taaaatagca aattttcgaa
    35761 actctctatt tcgaaacata acttcccccc aatctatacc ctgtcccacg aacagtcaaa
    35821 attatttgtg gacttgaagg gtcatcttct atcttctctc gcaagcgttt gatgtacaca
    35881 gtcaatgtgt tgtcattaac aaactcacct gccgcatccc acaattcatc aagtaatctt
    35941 accctcgtaa taatactttt aggattgcta ataaacacca ataacaaacg gtattctaaa
    36001 gctgaaagaa aaacctcatt gccattcttt ttcacaacac cggttgccgt atctacataa
    36061 agcccacaaa tttcaaaagt tgacccaaaa cgcccacttt ttcgtagtgc tgttctaatt
    36121 cgcgcaatca gttcacgtgg acgaaaaggt ttagtaatat aatcatctgc acccatattc
    36181 agtccagtaa caacacttga ttcatcaccg gaagctgtca aaaagataac aggaatgtct
    36241 tgcttttctt tgatttctgt gcaaatcgta aacccatttc catcaggtaa agaaatatca
    36301 ataagtgcca aatcaaattt attcttagca atctctacaa gtgcttcact tcttgtggat
    36361 acatgggtta ctataaatcc ttctgaatta agcaaaagaa taagattttt ggcaattgct
    36421 ttatcatcct caactaaaaa tatccgtttc atttactttc atcctccttt attttattag
    36481 ttttatatat tccagcagag caatagtaca ctactatttt acttatcatt acacaatttt
    36541 cagtagtttc ttttgttctt atataatcca tgcataatac ctccattgat ttattatatt
    36601 tcttataaca taaatacaca agataagaca aaaaacataa tgtaagtgca agttttttaa
    36661 ctcactaact tataaacata cactcctact aacactactt tcttgatgac acatcttaca
    36721 agcttatatt catacatcaa tgaaaaatta aatttatcca tttattaaaa taaaaggcaa
    36781 tagcttctat agctaatgcc ctttatctta aaatgattta aatactatac aatttttata
    36841 aatggctata aataaactcg tatagaatat aaaatttatc tacagtcttt tgttatacaa
    36901 aatttataac ctcttataga acaaatttac cactttgcaa acttatcact tttactcagc
    36961 tatattataa acttttaatt tatctttgtt taaatgtttc ttcttaactt ctactaaagc
    37021 ttttagcgta tccaaagatg tcattatttc agtagaaaat tcaatggctg ttcttctcat
    37081 cttaaatcca tctcttgtag agtcatttcc tttagttggt gtatttatta ctatatcaac
    37141 ttgtttattt cttatagcat ctaatatgtt tggtctaggc tcttcaattc tatttactat
    37201 atcagcctct attccatttt ctcttaaact cttcgctgtt ccttctgtag caacaaaagt
    37261 atatcctaat tctttcatat cttttgctat ctctataaac tcatctttat catgattatt
    37321 tacagtagca agtactactc ctctttcatc agacatatgt ctacctgctg ccaagaaccc
    37381 tttatataag gcttcttcta aattttctcc tacacctaga acttctcctg tagacttcat
    37441 ttcaggtcct agacttactt caactttaga taatttagac attgagaata ctggtacttt
    37501 tactgatact aattttggct ctttgtaaac tcctgtacta tatcctaaat cctttaattt
    37561 agctcctaac atacacttag tagccaagtc aactattggt actccactta ctttacttat
    37621 atatggaact gttctactag ctctagggtt aacctcaatt atatataatt cattttgaaa
    37681 ttctataaat tgtatattaa ccataccaag cacattaagg tctaaagcta tttttttagt
    37741 gtattctact attttttctt ttatttcatc agatatattt tgacttggat acattgttgt
    37801 actatctcca gagtgaactc cagctctttc taaatgctcc attataccag gtatcaatat
    37861 atcttcttta tcacatatag catctacttc tatttctcta ccagttagat atttatctat
    37921 aagtactgga tttttatggt ctctatcaaa tgcatcatcc aaatactgaa ttagtttttc
    37981 ttcgttataa gttatttcca taccttgacc accaagtaca taagatggtc taactaatac
    38041 tggataacct aactccttag caatttcaac accttcatta gttgtccata caccttttcc
    38101 ttttggtcta tttatatcta gtctctctag taaatcatca aatttttctc tatcttctgc
    38161 tgcatctata tctctaaagt ctgttcccag tataggtata tttttttcat gtaaaaactt
    38221 agccaatttt atagctgttt gtccaccaaa ctgtagtatt acaccttctg gtttttcttt
    38281 ttctattata tttaaaactt cttcttctgt taatggttca aaatacaact tatcagatgt
    38341 atcaaaatcc gtacttacag tttcagggtt attgtttaca attatagttt ctattcccat
    38401 ttttcttaaa gattttacac agtgaactga acaatagtca aattctattc cttgacctat
    38461 tcttattgga ccagaaccca atactacaac ttttctctta tcactaacta ctacctcatc
    38521 atattgttca taagttgaat agtaataagg tgatagagct tcaaattctc ctccacatgt
    38581 atcaaccatt ttataaactg gttgtatatt atataaactt ctcaattcat ataatttttc
    38641 tgggcttatc ttcattaagt cagatatacc tttatcagaa aatccctttt tctttaattc
    38701 atgtaaatat tctttatcta agtcttctat ttttagaact tttaactttt cttcttgttc
    38761 tactatccat ttaaatttat ttataaacca cttatcaaca ccagttattt ctgatatcat
    38821 ttctacttta tagcctcttc ttatcatttc agctaagtca aatagtctct catcatcagg
    38881 tactactact ctagccttta attcttctaa tgttctacct tctgatggag catgaaccaa
    38941 tgaatatttt cctgtttcaa gtgatcttat acctttaaga atagcagcct caaagttact
    39001 tcctatactc atgatttcac cagttgccat catcttagtt cctaattttc tattggcatg
    39061 tctaaattta tcaaatggcc actttggtat ttttactacc acataatcta atgttggctc
    39121 aaaacaagca taagtttttt tagttactgc attttctatc tcatccaaag tataacctaa
    39181 agctatctta gctgctactt ttgctattgg gtatcctgta gcttttgatg ctagggctga
    39241 tgacctacta actcttggat ttatttctat tatcgcatat tctaaactat gtgggtttaa
    39301 agctatttga acgttacatc caccttgaac ctctattgca tttattatgt ctattgatgc
    39361 ctttctaagt agttgatact cttcatcact tagagtttga cttggagcaa caactatact
    39421 gtctcccgta tgaactccaa ctgggtctac attttccata ttacatacag ttatacagtt
    39481 tccatttcca tccctcatta cttcgtattc tatttctttc caacctttta tactcttttc
    39541 aagaagaact tgtccaacag gacttagctg tagtccatgt gaaagtattt ctcttaattc
    39601 ttcctcagta tcagctatac ctccaccagt tccacctagc gtatatgctg gtcttacaac
    39661 tactggatat cctatcttat tggcaaactc aagacctgct tctaaatttg taactatatc
    39721 actaactatt actggttgat ttatttcttt cattacttct ctaaataaat ctctatcttc
    39781 gccctttttt atagattcta tagatgttcc tataactttt acattatatt tatctaatat
    39841 accagcatca tgtaattcta cagctaagtt taatcctgtc tgaccaccca tacctgcaag
    39901 taaactatct ggtttttctt tttctattat tttttctata aattctattg ttaatggttc
    39961 tatatatatt ttatctgcaa tttctttatc agtcattata gtagctgggt tactatttac
    40021 taatacaact tcaattccct cttcttttaa tgcttggcag gcctgtgttc ctgaatagtc
    40081 aaactctgca gcttgaccta ttattattgg ccctgaccct aatactaaag ttttctttat
    40141 actatctaat ttaggcataa ctctttctcc ttatctaaac aattttcaca gttcttatct
    40201 tcatcatcta tacaatcaac tttaattact ttattttatc ttaaattcaa atttactcat
    40261 caatacatct atttaataca tctatgttaa ttaaaccaaa ctttttgatt taagttattc
    40321 ttgtttttta gttagctatt ctaatgttat ttattttact aattctaaaa atttatcaaa
    40381 aatatagtca ttatcttttg gtcctgggca agcttcagga tggtattgaa cactgtatac
    40441 atctagtttc tcatgtctca ttccttcaac agtattatca tttaaattta tatgtgtcac
    40501 tttcatttgt tcaggaactt ctgaaacata ataaccatga ttttgagaag ttataaatac
    40561 ttttccttct tctaaatctt taactggatg atttccacct ctatgcccaa atttaagttt
    40621 agcagttttt cctccaagag ctaaagctaa aagttgatgt cctaagcata ttccaactat
    40681 aggtttttta ccaataagag cttttatatt ttctataaca tcttctaggt cttctgggtc
    40741 tccaggtcca tttgacaaga atattaagtc agggtttata ctcaatacat cttctggaga
    40801 tgttgtagct ggaaatattg ttatatcaca tccacgagct ataaatgatc ttaatatatt
    40861 tctttttact ccaaaatcca taacagccac ttttggacca tttcccttta tatgctctac
    40921 ttcttttctt gtaacagttc taactgcttc tgtatttgaa aacttatcca atttatgttt
    40981 aacatcttct aatttactgt cttctaatgt aattatacct ttcatggttc cattatttct
    41041 aagtatctta gtcaaagctc ttgtatctat tccttcaagt ccgataactt tattttgctt
    41101 taaatattgg tctatatcaa tttcacatct aaaattactt ggagaatcac ttttctccct
    41161 tactatgaat ccctttactt gaactttttc agactctgct gatgataaat ttataccata
    41221 atttcctaca agaggataag tcatagtaac tatttgacca tagtaagaag ggtctgttaa
    41281 aacttcacca tatcctatca ttgaagtatt aaatactact tctcctacac tttcttctaa
    41341 atatccaaat gcctttccta taaaaactgt tccatcttct aatattaacc ttgctttcat
    41401 actacagtac ctcctataat tctctttaga caaactaaag aacattaact aaatataagc
    41461 ttttaaatat ctatatctat ttttcacttt tacattctag ttttatactt atttacattt
    41521 attttttatc tttttctatt atactacaaa tttcttaaaa aaaagaagtt atctcaaaag
    41581 taaaaactcc tagaaaaaat aacctctttt ttttatttaa taattaaatt cttaaactat
    41641 acaatcaact taatttctat tcagctatat tgtaaacttt taactcatct ttatttaaat
    41701 gtttcttctt aacttctact aaagctttta gtgtatccaa agatgtcatt atttcagtag
    41761 aaaattcaat agctgttctt cttatcttaa atccatctct tgtagagtca tttcctttag
    41821 ttggtgtatt tattactata tcaacttgtt tatttcttat agcatctaat atgtttggtc
    41881 tagattcttc tactctattt actatatcag cctctattcc attttctctt aagctattag
    41941 ctgttccttc tgtagcaaca aaagtatatc ctaattcttt catatctttt gctatctcta
    42001 taaactcatc tttatcatga ttatttacag tagcaagtac tactcctctt tcatcagaca
    42061 tatgtctacc tgctgccaag aaccctttat ataaggcttc ttctaaattt tctcctacac
    42121 ctaggacttc tcctgtagac ttcatttcag gtcctagact tacttcaact ttagataatt
    42181 tagacattga gaatactggt acttttactg atactaattt tggctctttg taaactcctg
    42241 taccatatcc taaatccttt aatttagctc ctaacataca cttagtagcc aagtcaacta
    42301 ttggtactcc acttacttta cttatatacg gaactgttct actagctcta gggttaacct
    42361 caattatata taattcattt tgaaattcta taaactgtat attaaccata ccaagcacat
    42421 taaggtctaa agctattttt ttagtgtatt ctactatctt ttcttttatt tcatcagata
    42481 tattttgact tggatacatt gttgtactat ctccagagtg aactccagct ctttctaaat
    42541 gttccattat accaggtatc aatatatctt ccttatcaca tatagcatct acttctattt
    42601 ctctaccagt tagatattta tctataagta ctggattttt atggtctcta tcaaatgcat
    42661 cttgtaggta ttgagataat ttttcttcgt tataagttat ttccatacct tgaccaccaa
    42721 gtacataaga tggtctaact aatactggat aacctaactc attagcaact tcaatacctt
    42781 cgttaagtga ccatacaccc tttccttttg gtctatttat atctagtctc tctagtaaat
    42841 catcaaattt ttctctatct tctgctgcat ctatatcatc aaaatcagtt cccagtatag
    42901 gtatattttt ttcatgtaaa aatttagcca attttatagc tgtttgtcca ccaaactgta
    42961 gtattacacc ttctggtttt tctttttcta ttatacttaa aacttcttct tctgttaatg
    43021 gttcaaaata cagcttatct gatgtatcaa agtctgtact tacagtttca gggttattgt
    43081 ttatgattat agtttctatg tccatttttc ttaaagattt tacacagtga actgaacaat
    43141 agtcaaattc tataccttga cctattctta ttggaccaga acctaatact atcacctttt
    43201 tcttatcact aacaactacc tcatcatatt gctcataagt tgaataatag taaggagata
    43261 tagcatctat ctcacctgca caagtatcaa ccattttata tgctggtttg atattgtata
    43321 gacttctcaa ttcatataat ttttctggac ttatcttcat taggtcagat atacctttat
    43381 cagagaatcc ctttttcttt aattcaagaa gatagtcttt agttaaatct tcaattttca
    43441 taacttttaa tttttcttct tgctctacta tccatttaaa tttatttata aaccatttat
    43501 ctatacctgt aatttgttct atcatttcta ctttatagcc tcttcttatc atttcagcta
    43561 aatcaaatag tctctcatca tcaggtacta caactctttt ctttaattcc tcaatgcttc
    43621 tctcctcaga tggtgtgtga actaatgaat attttcctgt ttcaagtgat cttatccctt
    43681 taagaatagc agcctcaaaa ttacttccta tactcataat ttcaccagtt gccatcatct
    43741 tagttcctaa ttttctattt gcttttttaa atttatcaaa aggccatttt ggtatttttg
    43801 ccaccacata atctatagtt ggttcaaaac aagcataagt ttttttagtt actgcatttt
    43861 ctatctcatc taaagtataa cctaaagcta tttttgatga aactttagct attggatatc
    43921 ctgtagcttt tgatgctaaa gctgatgacc tactaactct tggatttatc tctataactg
    43981 catattcaaa actatgtgga ttaagtgcaa attgaacgtt acaaccacct tgaacttcta
    44041 ctgcatttaa tatatctaaa gatgcttttt taagcattgc acattctttg ttacttaaag
    44101 tttgagttgg agcaacaact atactgtctc ctgtatgaac tccgactggg tctatatttt
    44161 ccatgttaca tacaactata caatttccct ttgaatctct tattacctca tattctattt
    44221 ctttccaacc ttttatactc ttttcaatta atacttgtcc aacaggactt aattgtagac
    44281 catgtgaaag tatttctctt aattcttcct cattatcagc tataccccca ccagttccac
    44341 ctagtgtgta tgctggtctt acaactactg gataaccaat tgtaagtgca taatcaagac
    44401 ctgcttgtaa atctgtaact atatcactaa ctattacagg ctgatttatt tctttcatta
    44461 cttctctaaa tatatctcta tcttcacctt ttttgataga ttctactgaa gtacctatta
    44521 tttttactcc atatttatct agtatgcctt tttcataaag ttcaactgct aggtttagcc
    44581 ctgtttgtcc acccatacct gcaagtaaac tgtctggtct ttctttttct attatttttt
    44641 ctataaattc tattgttaat ggttctatat atattttatc tgccacttct ttatcagtca
    44701 ttatagtggc tggattacta tttattaata caacttcaat cccttcctct ttcaaagact
    44761 ggcaagcttg tgttcctgaa tagtcaaact ctgcagcttg acctattatt attggtcctg
    44821 accctaatac taaagttttc tttatactat ctaatttagg cataaatttt tctccttatc
    44881 taaatggttt ttactatctg taaataatac taaatctata ttaatgctaa gaatttatta
    44941 aatatacaat ctaaatcttc ttttgttgtg tattctggaa tgtactgaac actatatatt
    45001 ggtaattcct tatgtctcat tccttctata gtattgtcat ttaaatttat gtgagttact
    45061 tctgtatttt ctggcatttc tgaaacatta tatccatgat tttgagaagt tataaatacc
    45121 tttccagttt ctaaacattt aactgggtga ttacctcctc tatgtccaaa tacaagcttt
    45181 gaagtctttc ctcctaatgc caatgctaaa atttgatgtc ctaaacctat tcctgtcaat
    45241 ggctttttgc ctattaattt ttttatattt tcaactatat catttatatc ctctggattt
    45301 cctgggccat tagataataa gattaagtca ggatttatat ttaaaatttc ttctactgta
    45361 gtcattgctg gtactatagt tatatcacag ttacaagcct taagagactc tagtacacta
    45421 tttttaacac caaagtctat aactacaact ttagctccag taccttttat attttcaatt
    45481 tcttttcttg taacattttt tactgaatct ttgttacaat gctcttctaa tttagactga
    45541 acatcttgta atgatacatt ttctaaagtt ataattcctc tcttagttcc attgtttcta
    45601 ataattttag ttaatgctct tgtatctatt ccttcaagtc ctattacctt attttgcttt
    45661 agatatgtgt ctatatccat ttcacatcta aaattatttg ggttatcact tttttctctt
    45721 acaataagtc cttttacttg caccttattt gattcaacat cttctaaatt tattccatag
    45781 tttcctataa gtggataagt catagtaact atttgtccat aataagttgc atctgtcaat
    45841 agttctccat acccagccat tgaagtatta aatacaactt ctccaatagc ttcctttaga
    45901 tatccaaatg cttttccttc aaatactgtt ccatcttcta aaattaattt ccccttcatg
    45961 taagctacct cccaaatatt ttatctaagc attttctatt tctcttacaa tattaatagc
    46021 tgattctctt ggattttctg cttttgttat aggtcttcca acaactaaat aatgagcacc
    46081 tttttttatt gcatctgatg gagttacaac tcttttttgg tctccaacct ctgctgattt
    46141 aggtcttatt cctgggcaaa ctgttataaa atcagttcca catgcttcta ctattttatc
    46201 tacttcttgc gctgaacaaa caaccccatc tattcctgat tcttttgcca gtttagctct
    46261 ctttatagct aactcttctg ttgtcatatt acatcctatg tcctgtaaat cttggttgct
    46321 taatgaagtt aaaactgtta ctccaactac taatggcttt tctatattta atctttctgc
    46381 ttcttcccta gcaattagtg cacattgtct cattccttcc atatctgata catgtattgt
    46441 cattaaccaa acattatctc tcactgcagc tttcactgca cttttcatag tatttggtat
    46501 atcatggaat ttaaggtcta aaaatatttt tttacctttt tctttaagat aatctattgt
    46561 tttacctttt gtggcaacgt attgctctag ccctacctta aatatgtcta cactatcttc
    46621 taatctgtct attagttctt tagctttatc aaattcgtca gtatcaattg caactatcaa
    46681 tttttcttta ccatttatca tttttacatc tcctttttaa taaagcctaa ataatcataa
    46741 aaaaatcctc acaccaaaag aggcataagg attttatcta tacataactc tattcattag
    46801 ctatgagata tctttcccag tctctctgga ctagtttaaa agactttatt atatttaaat
    46861 ttttatttta tactcatcaa aaacctctag aagatttact agaggttata tactaacatt
    46921 atctataacc ctttagtctc tctggactac tttaaggaat ttagctgtaa tatttttctt
    46981 tatttatata actttatgta tctataggat aatttaaagt tttatctttt ttataattaa
    47041 accactaatt gctttttatg tcaataagtc tttgaattat tcttcatctt tatcaaacaa
    47101 ttttttctca aaatatgatt ctgcattata tattgcagca actggattat gcccagttac
    47161 tctatctttg acaactaaag ttgttatagg agcttccata tatttcatgg ctaaagtatc
    47221 gtgaccaaca cataatccaa gaattacatt aaggtcaacc ttagcttcat ttaaaaataa
    47281 agcttgtcct attggattgc acattacctc atctgaacac tttgatattg tttgagatgc
    47341 ttctagtcca attgtactct taggcattgc cccattttta catataacag aaaatacttc
    47401 aaacccatga tgttcaaata ttttttgcac tgtttgcatt tctcttttta gtccaataca
    47461 aaatgctatg ccaatctttt tataaccaca ctttttagca aactctataa tctcttttag
    47521 tctagtatat tgacaatacc cctctgcttc aactaatcca gcattataag ctatttttct
    47581 attctcttct tcttcataaa gttgctttgc tttttgttgt agttcaattt ctctagttgg
    47641 acatatcttc attaatttat ccatatttcc attagaacag cctctaagat tacattttcc
    47701 acacttatac atatccaata tccccttcca aaattttatt catcttgcga ttcttctttt
    47761 tctagagtta cattttcttc ttgggtttct tcttctggtt tcacatgctc gactacagtt
    47821 ataaaatatg attttcctat tttattcctt ataggaagtt tttcatatga aacatctatt
    47881 ttatttttta tacaagctat atcaaaatgt cttaaggcta cacctaagct aaccttattc
    47941 atatcttcac agtgtttctt aggtctcttt tcaaataaat gaagacctcg ttcatcctta
    48001 tggaaatacc acggttgaga attttttaca gatggagctc ttcttgtcaa ttctaagata
    48061 tctttccact ttctattcct atttatctta tttatcatat cttttactgg ctttctatca
    48121 ggtctagcat atctcgtcct aaacaactct tcattttttg ctggatatcc aaatgctatt
    48181 attatataag gattttctat tttgttttca tcatcttctt ctgtttttat tccagctaga
    48241 taatctaaat catcttcctc atcttcttca aaattcttat tcccaatatc tacaaattcc
    48301 aagatatctt ctctctttaa gtttccttcc aaccagcaag tagctattcc caatgttgta
    48361 aggcgcaaaa ctacaccttc tgtagcaaat cctatattct gtaaatagtc ctcacctttg
    48421 tctgatgtaa ctactatata atgaggtgcc tttactttac attccttacc catcaaaaaa
    48481 tgtattatat gacctctatc aacaacatgt gctttaatat ttaaatcttc atttaagtat
    48541 tctaaatttt tacaacttct ttttatttct tccatcaatg gcttttttat cttcttactg
    48601 gaaaaatttc ttacagattt tctataaaaa atggcttcat aaagctccat ttatgccctc
    48661 ctaactgaaa tcttctgacg tataaactct ataaatttat ataaatactt tatatttttt
    48721 atagttttat ttcctttttc ctcctgccct attttgaaat tcataagaat atctactcta
    48781 gtttaatata gcattcaaaa ggcttaaatt ctaccttatc aatgtctata cattagcata
    48841 atttttttat ttgattttct atgctaattt aaataacaac actagctatt acctttttaa
    48901 ttaagctttg ccagaaaaat tttttttcat ttataaatat ctatctcatt attatattat
    48961 aagttttttt cggtattctt gtatagcttt tcactaaaaa agtattttta tttctacttt
    49021 aatattatta tcaacaaaaa acatactgct taaataagtt tgttatcctc ataatttgtt
    49081 ttaattaaaa tatttttttt atttctcaat ctataaagta taaatatttt gaatatgacc
    49141 caaaatctaa gtaaagttat aatattttat aagttgttca atattaaaaa cataagtaat
    49201 gttataatac tttataagtt attcaatatt aaaaatatag gaggataaat atgaatttaa
    49261 atagaaattt agaaaaatac gctgaattag caataaaagt tggagttaac atacagccag
    49321 gtcaaattct acttataaag tcaccaatag aatgtgctga ttttgcaaga aatgcactta
    49381 aagaagcata taaatgtggt gctaaaaatg tttatataga gtggtctgat gaagaaagta
    49441 ctcttattaa atacttatat gctccagatg aagcatttca tgagttcccc aaatggacag
    49501 cagaacaata tgtagatata gcaaaagaag gtggggcatt tttatcagtc tatgcccaaa
    49561 atccagattt attaaaagat gttgaccctg aaagagttgc aaattttcag aaggcatctg
    49621 gaaaagcttt aaaagaatgg cgttcttaca ctctaactga taaatgtaaa tggaatatag
    49681 tctctgtgcc aacaaaagat tgggcaaaaa aagtgtttcc aaatttatca gaagataaag
    49741 caatagaaaa actgtgggat gctatattta aatgttcaag agtagatggt caggacccta
    49801 taaaagcatg ggaagaacat aatgaaaatc ttaaatctaa aatggacttt ctaaataaaa
    49861 ataactttaa aactttaaaa tataaatcct caaaaactga tttgactcta gacttgccaa
    49921 agggtcatgt ttggctaagt ggagcatcca aagaccctaa tggaataagt tttaatccga
    49981 atattccaac tgaagagatt tttggaatgc cacataagtt taaagtaaat ggaactgttt
    50041 atagtacaaa acctcttgtt tatggtggaa acataattga caatttcttc ttaacattta
    50101 aagatggtaa aataatagat ttctctgctg aaaagggact agatacacta gaaaaactta
    50161 ttgaaacgga tgaaggctct cattatttag gagaagtcgc tcttgttcca tacaactcac
    50221 caatatccaa tacggatata attttttata atactctata tgatgaaaat gcttcttgcc
    50281 actttgcaat tggttctgct tataagactt gtctggaagg tggaaataat ttaaaagatg
    50341 aagaattgga tgaacatggt gtaaatgaca gtttaacaca tgtagatttt atgattggtt
    50401 ctgctgatat ggatattatt ggtgagactt atgatggaaa gcaaatacag atttttaaaa
    50461 atggtaattg ggctttttaa catatgattt taactaaaaa gggctgatgg aagttatacc
    50521 agacttccca gcccttttta atgttgatga taaatatttt ttatattaat taatctcatt
    50581 attatagatt aattcctatt gttttaaaca taagtatcta aaacttatat ttatattata
    50641 tataaaatat cctatttagt aaaaccttta ttttaattta tatgctaaaa atttaacttt
    50701 gctatttcaa cagcagactt tgcatccttt gaataataat cagcacccat ttcttcagcg
    50761 tattcttctg tcaaaactgc acctcctaca aatacctttg catttatctc attatctctc
    50821 agtgcctgaa ttgtatcttt catactttga acagtcgtag tcataagtgc acttaatcct
    50881 actaatttta tatttctctt tttagcaact tccactactt cttcaatagg gacatcttta
    50941 cctaaatcta taacttcata tccataattt tctagcatta tttttactat atttttccca
    51001 atatcatgga tatcaccttt tactgtagca actattattt ttcctttgga tacattattg
    51061 ctacttttac ttaataaagt ttcctttatt gtatttaatg aaacttttac cgtttctgct
    51121 gattgaatca attgtggtaa aaatatatct ccactatcat atctttttcc tactttatca
    51181 agagcaggaa ttaaaatctc atctaatata taattttcat ccttctcttt taaaagattc
    51241 agtgttacat tttttgcttc atcttttaat cctctttcaa ctaaaatatc caagggcaaa
    51301 tctttatcaa tctttgtaga tgaatccgat ttttttgaat tatttatatt gctatattga
    51361 tttatatagt ttatacatcc tttatctgtg ttatttaata ttttaaaaga attgatagct
    51421 tccatcatac tatattcatt tggatttata attgctaaat caagccctgc ccctaaagct
    51481 aatgttagaa aagaagcatt aagtgctttc ctatttggaa gaccaaatga aatatttgaa
    51541 acacctaata tagtttttac tcctagtgtc tttaccattg ttatagcttt tatagtttct
    51601 attgcttctt cttgttgtgc tgaaacagtt aatgataaac agtctataaa tatatctttt
    51661 ggttttatcc cataagaaac tgctctatta actatccttt ttgctatttc aaatctttct
    51721 tcagcctttt taggtatccc cttttcatca agtgtaagtc caaccacaca tgaaccatac
    51781 tttttaacta ttggtaatat actttctaaa gactcctctt tgccatttac agagtttact
    51841 attgttctac cattataata tctaagtcct tgctctaagg cctctacatt ggaagaatca
    51901 acttgtaaag gtgtatctac tactgcttga atctctctta ttaattttgg cattagtttt
    51961 ttttcatcaa tctctggaag accaacattt actccaagta tttgtgctcc agcatttact
    52021 tgctctaaac ctaaatttat agcataatca acattttcat tttttaatgc ttcttgtaga
    52081 gattttctac ctgtgggatt caatctttct ccaacaactg taggcgattg tacttccaca
    52141 aattttgatg gtgaacagac tacacattta tcaattttct cgatacatcc ctttgtaaca
    52201 gaatttatat tctcagatat ttcttttata aaacttggat tcgtaccaca acatccacct
    52261 attatagtag caccaacttc aacgaacttt ttaacccctt caaaaaattc ttttgcatcg
    52321 acatcatata tagcctctcc atcaactata tttggaagac ctgcatttgc ttgaaccata
    52381 acagggactg tagctcttga tgctattttt tcaactattg gtaaaagttg tttaggtcct
    52441 aatgaacaat taactcctat tgcatctaca cctagacctt ctatagtagc caccatacat
    52501 tctggcatac atccagtaaa acttcttcca ccttcatcaa atgtcatagt acagaaaata
    52561 ggtaaatcag agttttcttt tgctgctaat acagctactt tagcttcata taaatccatc
    52621 atagtctcta ttactattac atcaactcca gatttaacgc cttgtagtac ttgtctttta
    52681 aatatttcat atgctttatc aaaacttaaa gtacccatag gctctagcat ttctcctata
    52741 ggaccaatat ctaaagctac atatcttggt ttagtattat ctacattttc tatagctttt
    52801 ctagccacca aaacagcatt gtcaatcact tcttctacag tatacttact atctaatttt
    52861 agttcattac atccaaaagt atttgtaaga attacattcg aacctgcctc taagtatgct
    52921 gtatgtattt ctataagttt atctggattt tgaagaccaa atacttctgg attttcacct
    52981 aactttaacc ctttttgttg aagcattgtt cccattgcac catcaaatat taatatatta
    53041 tttttcagat attgtcttat ttccacaaga gttcgctccc tttctatatg tacagtttct
    53101 atagttttta caattttcac acgacttttc tttcttagat ttatttattc ttgtattaga
    53161 aatacctata atagccacta ctgactttct cggtatcata attccattag aagtaattgt
    53221 tagacctatt tgtttttgag cattcaaaac gtttaatata tctatatttt tttctattgg
    53281 taaatctcca tatcctgggc tatatcgcat agttataaat ttatcttgct ttaaaaaaac
    53341 cttttctaaa ttattttgaa caatgtcaca cacttcttct attgctgttg ttccacatga
    53401 atcaattatt agtccttttg ttaaatttga ataagagtgt cgtcttattt ctttttctat
    53461 atctatccct atagtagctg ccataattac acactcatta cattctttta aaagttcata
    53521 tacatattta ctctctaatg ttaaatttgt tccctctaat tctacaacat tatctttatt
    53581 tattctaata ggataaatcc tagataaata tctaggattt attttatttt tagttatagc
    53641 tacacattca tcaatagtat atttaaggtc tttatctatc tcttgacctc tgtattgtaa
    53701 atatcttaaa acttcacttt gatttatgct tatatcttct cttccaatta aattattctc
    53761 catatatatt taaagaaaat cctttatcta aaacatcttt tgcatattcc tttgccccaa
    53821 ataaagataa gtctctgtag tttccacatt ctatagctgt agctgctggc attttatctg
    53881 attcaagaac tttttttaat gcttcttcta aaccaatctt aactgttttg gcatctacat
    53941 ctccccatag tattaaataa aatcctgttc tacatcccat tggagataag tctattacac
    54001 catctaatgt atctcttaaa taagtagcta aaagatgctc taaaccgtgc atagcagcag
    54061 ttccaaaact ttctacattt ggctgtaaaa atctcaagtc aaatttagtt actttatctc
    54121 cctttactcc atcaagtaca ctacactttc ttacaaaagg agcttttact tttgtatggt
    54181 ctagcttaaa actttctact ttttccatta tttaatcctc cattatactt taaaatttgt
    54241 tacattaatt ctaaaaaaaa ctcttcctat ctattattga taagaagagt atattatttc
    54301 aagtcatctc atcgttgtta gcaggaccac ctgataaaag gttggtatag gatcactgag
    54361 ctaactctct cccctaactc ttgataagta tcttattaaa ctgacttaaa ttatatatta
    54421 cttttttatt tttgtaaaca ctttattgtt ataatattta tatcacataa tcgtactttt
    54481 attttataac taagctgatt gtattattgg cagttgtact tcaaacacag tttgatattt
    54541 atcgcttgaa acagtaattt ctccatcatg taaatttaca atattttttg taatcgcaag
    54601 acccaatcca gaacctccaa catttctatt tctcgatttt tcaactctat aaaatctatc
    54661 aaatatattt ggtaaatcta acactggaat tggttcccca taatttatca cttttacaac
    54721 cgccatatct tcctttttct ctgtgactat atctacataa tgcccatctt ttccatattt
    54781 cacagcatta gttataagat tttcaaatgc tcttaccaat ttatttggat cagcttttac
    54841 aattaatttt tcttcattaa aattaattct actaaccata aattcttgtt taaaataaat
    54901 ttcaaattga gatactactt gacttaataa ctctactaaa tttatttcta ttttgtttaa
    54961 ttttattgta ttattttgca ttttagtcaa ttcaaacaaa tcatttataa gaacatttaa
    55021 atttttcgat ttttcatatg caatatcaac atagtacatc atctgaactt catctttata
    55081 cttaccttct tctatcactc ctaaataacc cattatggat gtcaaaggtg ttcttaagtc
    55141 atgtgacaca tttgttatta aatctgtttt tgtctgctga gcttgtctct cttcaatagt
    55201 tatatttcta agttgatgga ctatattatt gattttatgt gctagttcat caatatcatc
    55261 cttttcttta tcctttaata tatctaaatc atactcaata tctatacttt tttctaagtt
    55321 accttcatcc attaaattta cagcactttt aatgatttct aatttttgat tttttctatt
    55381 agtctttctt ataaaatcta caatttgctt atttctcttg tacgatataa tggaataaat
    55441 tgctaatgat gtgattgtaa ataaaaatgg ataaaataaa tcatacccta taagacttct
    55501 gaaatctctt gcttgatata caagttgatt aactacagac atatcactat tgacatataa
    55561 tgattttatt atatacatac ttgttaaaat aagcattgaa gttaaagcac agcttattat
    55621 aagatctaat atgggtcgaa acatatgatt taataaactt ttatttttca attttatatc
    55681 ctactcccca tacagtatga attatttttt ctccatctgt atatttttca attttatccc
    55741 ttattctgct catatgaacc attacagtat tattagattg gtaatatttc tctttccata
    55801 ccttttcaaa tatttcttct gtactatata ctctgccttt attatttgct agtaaatata
    55861 atatatcaaa ttctcttgat gtcaaaatta tttcatttcc agccactgtt acactatgtt
    55921 tttccttatc tataattact actccaacct ttatgacatc tttatcttca ttattagcac
    55981 cactaaaata atatgctctt ctaatcagcg acttcactct cacagtaagt tcaagtgggt
    56041 taaatggttt tgtcaaatag tcatctgcac cagtcattat cccttgtatt ttatccatgt
    56101 cttctgattt tgcacttaac ataagtattg gtatattcaa actttctcta acttttctac
    56161 aaacttctat cccatccatt ttaggcatca ttatatccaa tatcattaaa tgaatatttt
    56221 ccttttttaa aatatctaga gcctcttttc catcttcagc tttaattaca ttatatccac
    56281 tatttaaaag atatatctct ataaggtctc ttatttcctt ttcatcatcc acaacaagaa
    56341 ctgtattatt catttttaca catcctaact taatctttgt atatagcttt attcatataa
    56401 aattatacta tattttagtt agtgtaatct ataaatttat taatttctaa atttccaata
    56461 taatacaaat tatttacaca tttatattat ttattttgta aatattcttc taaagttaat
    56521 ccttttgaat aaatttcctc agcagcatcc ttaccaacat atctaatatg ccatggttca
    56581 tatgctgtac ctgttatatc ttctttacct tcaggatatc ttattataaa tccaaacttg
    56641 tgagcatttt ctgccaacca tttagcttct tttgtacttc caacaaacca tctttctgga
    56701 tttgttaaat caatacaaag tccagtttgg tgctcactgt aaccaggctt tgctacatat
    56761 gcatctgcct tttctcgccc ctgagatttt acccttcttg tataagtatc cagttgagta
    56821 tcataagatc tgtatgctga agaccctaaa aactgtattc cttctgaatt agcttgctta
    56881 actaaatctt caactgcctt tgcaggttct cctgccattt gtttttcttc ctctgttgct
    56941 tcttcaacaa aaggtatgtt taccttagta atattttcag gagtatagtt tttgctaatt
    57001 ccatttgtct tgtttaccaa taatatattt gatatactat ttgagtgatt tttattttga
    57061 gaatttgcct caacatcttg ttctgaatca tgttgagcag ctactattgg atctttatct
    57121 ttcttaagta atctatcttt agatataaat acacttataa atactactaa aataatggct
    57181 cctattaatt taaatttttt cataattaaa tcttctcctt tttgttatgt ttgctataat
    57241 gttaatttta gagtataaga cttaagtatt ttataagtaa atcttaaata aatcttaaat
    57301 ttaatatttt taaaggatgg tgataaaatg tctatacaaa aacttctaag taaagctcgt
    57361 aaggctatac aagattttga tatgatacaa gaaaatgata aaattgcggt tggactttct
    57421 ggtggaaaag atagtttaac tctacttcat atacttaaaa gttatcaaag attttctcca
    57481 caaaactttg aattgatagc cataacatta aatactggag gtgttgataa ttctccacta
    57541 gataaattgt gtaaagaaat aaatgttcct ttttatgaat ttcaaactga cataaaagaa
    57601 attgtatttg atataagaca agaaaagaat ccttgtgcat tgtgtgctaa tttaagaaga
    57661 ggtgctttga acgataatgc taaaaaactt ggatgtaata aagtagctct tggtcatcat
    57721 aaagatgatg caattgagac atttttaatg tctatgtttt atgagggtag agtaaattgt
    57781 ttttccccaa agacatacct agacagacag gatttaacag ttataagacc tatggtttac
    57841 atagaagagt atatgactaa gaaaatttca aaagattcta actatcctat tatcacaaat
    57901 ccctgccctg caaatggtca tactaggaga gagtacataa aaaatcttat tgctaattta
    57961 aataaagaga tgcctgattt taaaagaaat gtatttggtg ctttaaataa ttctgagaaa
    58021 ttgtttatat gggataaaga gaagataaaa aattttaaat aataattaaa atttttaaat
    58081 aaaaaagcaa gattgtatta attgtaaata atctttatat aatctacaca atcttacttt
    58141 tttatttatt atatgttatt atctttaatc tatattttaa tagttcttaa tagtatttat
    58201 tttgtctaat acattaatta taacttaaat attttatata ttaatttaat ctattaattc
    58261 attcaatcta ctggtttaat ccatttttac agtatataca tctacatatt ataaaaagca
    58321 aaattatatt ttctaaatat tttatgttag attataatat taaattctat tatctctggt
    58381 atattaaaaa atctaaatgg taactttgta cttccaagac ccgaactcac atataaatga
    58441 tttccattta tatcataaaa ccctttagta tatttccttc catatggagg agtaactaat
    58501 gctcccttaa taggtaatct tatttgacca ccatgactat gcccagatag aactaaattc
    58561 attgtatctt tactaagcat atctactaaa tctggttcat gtgctaacaa taaattaaaa
    58621 ttcttattat ctatttgact ctccagatat tttatattag gatttccatt taatatttca
    58681 tcaacaccta atatattaat atatttatca tcttttaatt ttattttttt attttcattt
    58741 actaaaagat tgaagttgga atttttcata atctgcctat aatacctagg aagtttatac
    58801 atataatcat gattgccaaa tactgaaaat tttcccaacc tagcattcat acttgataaa
    58861 atagttgtaa tttcatctac acttggattt ttattggagt aatcaattaa atcaccagta
    58921 aatactatta tatctggatt caaagtgtta atcttattag ctactttttt gagattctta
    58981 gttgaataaa aactacctat ttgagtatct gaaatttgaa ctacttttat cctttcagat
    59041 ttactctcaa ttgtatcact ttttatcaat gttccatttt cacttatatt atattttttc
    59101 acaattaata gactcggctc tatcgcaact gagtatataa aaatcaaaat aaatattaag
    59161 ataaaaaatt ttaaaaaata cttaattttt gagttcaaaa tatctaccta cttatttatt
    59221 tttttaaact atttgcatta cagactcaac tttgttcatt tttctgtcat gcatttttgg
    59281 cttatttgct gaaaaccatt tatatgttgc tgtaagacct tcttttagta acacatttgg
    59341 tatataaagc ccatgttcaa taagcttatt tatatcaaga ttaaagtcta tatttctaaa
    59401 tgggaaatac gttctttctc taaactctac tttttccata tctacatatt ttattatagg
    59461 ttctttgcca ataatttctc cacatgtata tataaggtca tcccaagaaa ttaactgtgg
    59521 atttgtcaca ttataggcct ctcttacatg aggatttttc attatgcttt ccaatacctt
    59581 taccaaatcc ccaatatata taaattgatt actaacttgt tttccttttg gtactggtat
    59641 cttttcattt ttttctattt tttcaaagaa ataatactct ctatataaat tattattttc
    59701 accatatata taagttggtc taataattat atatggtata gggctattta taataaaatc
    59761 ttcagcctct tttttattta acccatattt tccccagttt tcattttcac ctttctcatt
    59821 ttcttctttt atatttcttc cactatcttt atatactgct cctgctgaca atactatata
    59881 cttttttaag ttatccatac ttataaaatc aatcagatta cttacatctt cttttgtata
    59941 tgctgtcata tcatatatgt aatcatattt tcttcctgtg ataatgtttt ccatatcttt
    60001 tcgaactttt ctatcacaaa ttagatgttc tttaaaacca ttataatcta tttccttttt
    60061 accatttgta agtatatcaa tttgataccc acatttaatc aagcgcttag caagtgcaga
    60121 acctatgaag tcgcttccac ccataattaa aatagatttc attttaagtg catcctcctc
    60181 ttttttaaat gacttcctta actataatat catattttta aatatgcgac accattttgt
    60241 aatatttttg tctataaaag atatttataa caaaatatct tttatagact ctacattttc
    60301 gacaatataa gtaggttcac tttcactaag ttcttcaaaa gaaccatacc catacaacac
    60361 tccaatagaa tctataccta tttttttggc tccaattatg tcatactttc tatctccaac
    60421 cataataact ttatctttat cttttacatt acataggtct agtacatatt gtataacttc
    60481 atttttattc actcttgtac catcaagatt gctacctgct atatatttaa aatatctatc
    60541 tatatcaaaa tatctaagta tagtttctgc aaaaactgtt ggcttagaag ttgctactaa
    60601 taatatttta ccatttttat agagcatttc taatatctct tttatattct catagatttt
    60661 attttcaaat atccctttat cagcaaaata ttctctatac ttttcaacag cttctttagt
    60721 ttttttatct tcaaatttat aatactcctt aaaagtatca tgtaatggtg gtcctataaa
    60781 ttggtctaag ttttccaaat cttcttttat gccaaagcta tttaaagaat actgaataga
    60841 ctttgttatt ccttctttag ggtctgtaag tgttccatct aaatcgaata atactatttc
    60901 ataatttttt ttcatatttc agtcctccat atttgtaaaa agtaatatct tatatattaa
    60961 gtttatctat tttaaaaagc tatagtaata gaaatttcta atactatagc ttaagtaccc
    61021 aattaaatct tatatattta ttttaaaaat aaatttaaac agctctattt aactgttata
    61081 gctgaaactg gacatccttc ttcggcttct ttacataaat cttgtaagtc tgctggtatt
    61141 tctccttcaa ttgctactga atgcccttca tcgctcatac taaaaacgtc tggacatgtt
    61201 cctatacatg ctccacaagc tacacataca tccttatcaa caaatgcttt catactaaaa
    61261 tacctcccct aaaattatta ttttttaatt gttgtttcct tagatattta tccaatatat
    61321 accaatttaa acatatattt attattttat cactattgtt tagtttatta tagtattttc
    61381 gtatccatgt ctataaactt cactgctttt catccatgat tttacagtat attgcaatct
    61441 taatttttta tttaaaacaa gttcattatt attgtagtct tttataatat cattacactc
    61501 ctccattgtg aatattgtaa aatcaccttc tccaccaatc tttattctgc ctttatttcc
    61561 atgtaaatcg aaaatctttg ttgggtattc agttactttt tctatacact tttctaagga
    61621 tatcccaagt tccataattt tatttataac acttaaaaga gaatagttta cgtctttcat
    61681 gttttttata tgcatatcag tacttattag gtctggctct aaaccttgct ttattgcttt
    61741 tttaaaaact ttaaaatcaa attggttcaa tccatgacat acatcaaaca atactcctct
    61801 gttctttgca tttattactg attttcttaa tgtgccagat tctttaagga ttccatttgt
    61861 actatttcca tatactggtg taaccacatc tccttttccc aaaatattca ttacttcatc
    61921 tatatatgat ggatactctc ctatatatac cactaagggt aaatttaatt ttttggcaac
    61981 ttgctttgat ttcttaatta tatctatacc actttcatta gattgaaatt tactcgcttt
    62041 tacttttata ccctttatct tttctatatt tttttctaca actgactcaa ccttgtcaaa
    62101 atttataaca tctaaagaag ttgattcatt caatatattt agtccctcat ttgtaacatt
    62161 taaaaaagaa tatacttctg ttttacactc atccatatac ttttttttaa aatcatagta
    62221 gtttaaagga ccagctgtac ctgcatcaaa tataactgta gaaccttttt caattccaat
    62281 tgaatcagaa tccatacctg taggtaattt tctcttataa caatgggtgt gaacatctat
    62341 aaatcctggg gaaatataca tattatcggc atttattatc tcgaactctt tatttgtaag
    62401 taatttttct tttcttattt tctctttaag gttcaatcca atagcatata ttttcccatg
    62461 taaaaccaag atatctcttt tttcaaattt gataccatct gttggagata ttattgtccc
    62521 atttcttata agcaaatttt tcatttattc cacatcctaa ttacaatata atttctctaa
    62581 tagcttttct tacataaaga aaataagcct aaaaataaaa atattttaga cttattcact
    62641 atattatact atattaatta tattaaatta aataaaatct ttaatttact ttaagaagca
    62701 attaagtatc tgttgttcgg cttcttcttc agtaagacct aatgtcatca tctttagtat
    62761 ttgatctcct gcaatctttc caatagctgc ttcatgtact aaaagagcat ctggatgatt
    62821 tgcagcaatt tcaggtatag cactaatttg agaatttccc ataattattg aatcacattg
    62881 aacatgtgca gaacaaaggg aatccccaat aacacaagga ttaaactttt gcttagaatt
    62941 atcttgccca actgtacgag aaactacttg agcagaagag ttttccccct ctaagataac
    63001 cttcatatta gattctgcaa cttgattacc atgagttaat aatttctcaa atacaactat
    63061 tttagctcct ttacctaggt ttgcatccat ttctctttta gttgaatcta cacccttaat
    63121 ttgaattgtt tccatttcac aatatgaatc ctcatccata ttgacaatag taactggatt
    63181 taaaattctc tttccttctc catcaccttc accataatgt ttttctacat attttaggcg
    63241 agctccttta cgtaagaaaa atctatgtat accattatgt tcactatcat cacaaccaca
    63301 gttatgtata ccacacccag caattataac aacatctgca ttttctccaa tttcaaaatc
    63361 attatatacc atatcctgta caccagtctc tgttactatt actggtatat gtacattttc
    63421 tccttttgta tttggcttta ctataatatc tattccaggt ttatcagttt taggaattat
    63481 agttacattt tcagttgaat gtctctctac tccttgccca tttttacgta tattgtatgc
    63541 tcctaatgga gttccacgaa gttcagcaac tttttctaaa agatttaaat ctattttgtt
    63601 catttaattt gccttccttt ctaattaatt catgtctttc attaattcac aacttgaatt
    63661 aacttgacac atgatttcag gtaatatagc ctcttttgtt ccatggcttt ttactgaacc
    63721 atcttgtaga acaattattt catcagctaa ctctaatatt ctttcttggt gagaaattat
    63781 gattatagtc tggttagact cttcatgtat tttcttaaaa ctttcattga gtttcccaaa
    63841 gctccaaagg tctatccctg cttcaggttc atcaaatata gaaaccttta aatctctagc
    63901 aaaaagagtt gctatctcaa ttcttttcat ttcccctcca gaaagagagt tatcaacttc
    63961 acgatttaaa tagtcttttg aacacaatcc aacatctgta agatattggc aacatacatc
    64021 agtagacaat ggttttccat gagcaagtgt aagtaaattt tcaactgtca taccttttat
    64081 tcttggtggt tgttgaaatg catatcctat tccttttttt gctctttctg taatactaag
    64141 atttgttata tcttctccat ctaaaattat ctgaccactc gtagcttttt caattcccat
    64201 aataagctta gcaattgtag attttcctcc accatttggc cctgtgataa caataagttt
    64261 tcccctctca aatgaaaggc taacatcatt tattattcct agttcctcat tgttagactc
    64321 aacattaaag gaaagatttt ttatttcaag cataataccc ctcttttcta taaaatatta
    64381 cattaatatc cattctttta ttatatcagt aatttttata tatcagcaac tctaagcaga
    64441 taaaatgtat attaaataat aaaacaaagt tattgaaaag taaaaaagat gagttttatg
    64501 taaactcatc tcagaaattt agtatatcaa cttatatgta tttaaaaatt agccttctat
    64561 atactctaat attatttttt gattatcttt taacataatt tcttcttttt tagattctat
    64621 tccattcttt tttatcttca cctcagctac aaaggcatca ttaccttcaa ccatttctaa
    64681 tagttcataa gcttttttac gacctatttt agttgctata tcttttagta ctgccatttt
    64741 cttaaacatt ttatcacctc tactcaaaat ttacacttaa tttttaatta tataattcta
    64801 atcctagact agtttataat aattattgtc tctaattata tcagatattg agtaaattta
    64861 atactttgta aaattattta tcctctctga ccaaataatc atttccatct tggtctttaa
    64921 aagaaaacat ccttccatat ggcatctcca ttaattcccc aacctcaacc tcgttatttg
    64981 ccatttgttc ataagttcca ttaatatctc ttgtacttaa aattattgat ggatgagata
    65041 catttatctc tttgttttgt ctcatcatta gatttttatc atacaacaca aatgttgtaa
    65101 attcattttt acttggtgct acttccaccc atttcatatt tggacccatt tccttttcat
    65161 aagttactac aaagttcaat ttttctgtcc aaaacaactt tgcatcctct tgattattta
    65221 catagagagt tatttttcct attttattta tcataacaat acccaccttt attattaaat
    65281 aaatacctaa tattttttat atttaataat atacccatat atattatttt ctatagatat
    65341 atatttctaa tatttatcgc caaattatgt aattctgctc aatatataat ttatagtatc
    65401 catactatta taggctttat ttatgtaatt taatcacctt atatatcata cttataatta
    65461 tgataataac tacataaaaa atcacttcta aatagagtta tccatctaaa agtgatttca
    65521 tatattctat gcaactttgt gttttagcca ctttgttcct cttaatctta aacaatataa
    65581 agtccctcta acaagccaat cagtatacat acctatccaa attcctaaca ctccaaattc
    65641 taatacaacc cccaatacgt aacctgtaaa aattctaaaa atccacatac ctattactgc
    65701 agtcatcatt gtatatctag tatcaccggc tccctttagc cctgctgata atacaaagga
    65761 tataggccat attaccatag ctaaacaatc acttcgaatt aattgtgttg agatgtcaat
    65821 tacactagca ttttgagtat acatacttga aatccaaggt gcaattggta taaatatagc
    65881 tcctactata aataaacaaa ttgttgcaaa tttagttaaa tataataaag tactcttagc
    65941 tcctttaata tctccacgtc ctatatactg tcccaccaag gttgtagcag acaaagctaa
    66001 agcattccca attacattta ttatggatgc aattgacatt cctattgcat tggatgcaat
    66061 tgctgatgtt cccatagtaa ctataaatac ttgaacaatc aatttacctg cattaaaaag
    66121 tagttgttca actccagctg gtattcctat attaaatata gacttttgag tttcaacatc
    66181 aatcttaaat ggaaatattt tacccataga tataaattcg tttcctttaa ataaagctct
    66241 tataattact atacatccaa ttattctagc tatagcaata gatatagctg cacctgttat
    66301 gccataggat ggtgtttgca aatttattcc tagaggattt aaatcaatac catatataag
    66361 tatatatcct aatgttacat ttactatatt cataaacata gtcacataca taggtttctt
    66421 tacatctcca caccctctta aaagaccatt tgctatttgt tgtgtcgcaa taaatggata
    66481 cgtaaataat gtaaactcta tgtataattt tgcatttgat tttaccaatt cttctgcgga
    66541 accataaaat aaattaatta caccagttct aaaaacccac atcaatattg ttattgtaaa
    66601 ggataatatt actccagaca ctagagcctg cttaatagtt tcattcacct tttcaccatc
    66661 tttttttcct atttgttgag ctacaacaac agtagctcca acagatagtg cagcaaatac
    66721 agatataaat atattgttta ttgaatcaac cattccaact gcagatacag cttcttcccc
    66781 aatatgacct gccatcattg tattaaatac tcctaaaagc atgacaaacg tctgctctat
    66841 cattatagga attgctaact ttataacatt tttccttata aacatcccta ttcctctttt
    66901 ccctctttat ataaatttaa tttttaatta gtttatcgaa ctgtaaattg acaatgcaaa
    66961 gtttagaatt gtattgttcg cattataata tactgctttc aaataatata aatcttgttt
    67021 aatatcattt gaacacagta tatctttata attatcttat gtttattatt ttttatggat
    67081 accacattta aaatatttat taatttaata taaatatttt ccgttattat taaaagtagc
    67141 tatatttcgt taatattgta tcactatcgt gtagcaataa caataagtac attttatata
    67201 ttttttataa tattatttaa tcatccaaac ttttaccact ttttcaatat ataaaatatt
    67261 acactttaga tgtaacaaaa tcgcatccat ttaaatattg tattttatag actaatttta
    67321 ggatgtgata ctttggttaa tttaaatgca aataatctaa atgtaaatat ggtttatcct
    67381 atttcttcca cagcacccat acgtttcaga agatatactg tttcatattt agaaaacatg
    67441 gaaaatattt atttaactat agcaacatac tttgatacac ttggtttagg cacaatgaat
    67501 atcgacaaag tttatggtca atgggcttgg tttactgata atatatatga tttaaatcta
    67561 tttgtttttg taggaaatta tccttatcaa attgctaaaa acagatatga tacatttgta
    67621 gatattttgc cagtagctat tacttctatt gtcaatggag atagaatatt tttaatttca
    67681 aatccttgtt tgttaaattc aaaaattaca gttagattta tatctagtca tcctactctt
    67741 aatagaacag ttgattatgg caatattaga gattttattt tttaaaactg caacatgatg
    67801 tgctattaaa aaatacccta aatttaatga tattattaaa taactagaat atttttaatt
    67861 ggcacatcat gcctagctat tataaattca taatattatt ttacttaaga taagtactgt
    67921 attttatcta cttgtatatt tttatttacc tagtttctca gttctatatc ctatttcttt
    67981 attagctagc ttataacctt cttgtatcat ttcttctctc gttaatgcac tccctaataa
    68041 attgtcaata ctcagttgct ttctatcact aaaatactta tccaataatg attcctctat
    68101 atcttcctga tatgccaaat ttccttcatg cattatatat tttacatcaa aaccttcttt
    68161 atttaatact tttcccacca agatacttct atgacatctt ataggttctt gcatagctcc
    68221 taataaaact atcctataac ccatttgaca accctttttt aatctttcta ttccgtttaa
    68281 aaaaatatct tcttttgcta ctttctcaaa atctgcataa ccttcttgcg tatatacatc
    68341 tttattagtt cttttagctc caaattcttt tcccatgtat atatataaaa atccggaatt
    68401 tctaagagat tcgttaaatg cctctttatt gtattgaata ttatatttag aatatggagt
    68461 ttctctaatg tcaactacac aatttatgtc atattttttt atcatattaa taagcttatc
    68521 atatggataa tttgaatgtc ctattgcgaa tatttccata taaacaccct cctattcttt
    68581 gaaattagta tctatatatg tagatacccg atttacttaa aattaaataa agtattactt
    68641 taaataccca atatcttttt ttcttgatat tgtatatttt tttactttat atccttaaaa
    68701 aaatatacaa ctttatatat aaaacatcaa tatttatata tattttgtat attaaataca
    68761 attatttata aagtctttaa taaaaattta taaatagagc atctttagaa aactattata
    68821 ataaaaaaat aagaggctgt ctaaaaatat agataagcct tttttcataa tcgtaattat
    68881 aaaaatatac ttgatttcat atgaaaaaga gtgtctcata aactaaaatg tttactttga
    68941 gacaccacct tttttattct tatttatact ttgtagacat attataacat gcgtttcact
    69001 ggtatctgaa cttctgtcaa ccagtcttct tcactctctt tattccatat accatctata
    69061 taagattctc taggatttcc aaccacttta tatttattgt cctctatcca tttaaatgca
    69121 tctgcgtaag tttttcctaa tgttgaatat ggaccattgt gtaatataca aactgcattt
    69181 tcaactgcat ctaattcttt aaattttaat atatccgtat cttcctttaa atcatttata
    69241 gcttgacaca tttcaacatc catatcagtc tctctatatt caccatcatg atatatatta
    69301 aaacaataat caggaactgc acatgtacac cctgttttca tcatttcttc agccattaca
    69361 tttggaaata gattaaaaag ttcatcatac ccctttaaca cttttctcat agaagcaact
    69421 ttaacttttg gtaaagactt aataattaca tcattcatat tgacttctcc tttcaaattc
    69481 ataaggtaat tacgtagttt aattatttta tattcttcac ttttaattac atccaacatt
    69541 tctttttctt tattcattaa aatattttca acttcttcag gattttctac agcttttttt
    69601 atctcagcta atgataaacc catttgtttt aaagttatta tctgatgtaa tttaggtaat
    69661 tgctctgttg tataatacct atattttgta aattcatcta catattctgg ttttaacaac
    69721 cctatatctt cataatacct taatgtcttt gtagttattt tatttatttt agaaaacatt
    69781 cctatagaaa acatctcatc acctgcgcat tagatttgat taatttaagt ttaaactttc
    69841 cccttaggtt aaagtcaata caaaataaat tataattgta ttaattcttc aattctatct
    69901 ccactcaata ccaaaatatc ccctgttttt ataatggttg aacctttagg tattaaaacc
    69961 tgttcctttc tttttatcat aactattaat atatcgtctg gtatattaga atctattata
    70021 ctcttattag cccatttatt accctcatca acatttactt cgataagttt agagctaatt
    70081 tctccatcat aatcattaaa tgtttttaat acaggtgtat tatcatcaac taaatccaac
    70141 tttctggcta cagttggtat caatgaacct tgtattccta ctgaaagcaa cgctataaaa
    70201 aatattatat ggaatatgtc attctctatg gctactcctt gagtaacagc ataaattgca
    70261 aaaactactg aagccgcacc tctaagacct acccacgata tgaataattt ttctttattt
    70321 gagaatttaa attttgctag aactataaat gttgctaatg gtcttgcaat aactatcatg
    70381 aatatagata tggccattgc tataccaaat acatttggta acttagaagg gaaagataac
    70441 aatcctaaca taaagaataa cattatttgc ataatccatg aaattccatc aaagaaatga
    70501 accaaacttt ttttaagagg tatcctacta tttcctataa taatacctga aatgtaaaca
    70561 cttaaatatc catttcctcc aagatactcg ctaaatgcat aagaaagtat tgcaatagct
    70621 gttataaata tagtataaaa tccttctatc tcgaagtttg aatgtcttaa aatataaaca
    70681 gataattttg ctagtataaa tcctatagct aacccaaaag ctatttgttt tattaccatt
    70741 ggtgcaataa gttctacccc agaattattc atcaatgtca aaagaattag tgtcaacata
    70801 tacgctattg ggtcattact tccactttca acttctaata atgatgcaag tgaacccttt
    70861 aagtttagtt tttgagaacg caacacagca aacacagatg cagcatctgt tgaagctgca
    70921 attgccccaa ttaataaacc ttcaagtaaa ctagttccta ttaccatgtg gcaaaacata
    70981 cctgtaaccc cagccgtaat tattacaccc agtgaagaca ttaatataga aggtatagca
    71041 acaggtttag ccatattcca gtttgttcca aaccctccaa aaaacattat aaatattagt
    71101 ccaatagaac ataattgttt tgtcagttca tagttatcaa aatagattcc taccatccca
    71161 tcagacccaa ataacatccc tagtaagata aaaatcaata atattggtac tccaaattta
    71221 tacaatacct tgctagaagt tatacaaatc aatagtacta acccacttat aatcattaat
    71281 tctgtcatag catcaactcc atttcatata aattttgtag attaatttac atctacaatt
    71341 ttattactta ttcaaatata acatgacata aattttataa gttatggtac ataaagttca
    71401 acaaaaattt cacaatacat taaaatgtga gtgttatact taaatttata tatttgtttt
    71461 aattatattc atttaatatt tataatttga attttttttt attaatattt cattttttag
    71521 ttgattgttt aatatatttc attttttata gtaattttat atataactac gaaatataaa
    71581 gtaattagat aagtaacaag aaactaacat gtaatgttag gtactctaga tatgaaatct
    71641 taaaactttt aaatattgaa atatttcttt atatatatta ttgtatattt cttataaatt
    71701 attgtcaatt tattttttct taaaaataaa ataattgcat aatttatttc aaattatgca
    71761 atttataaaa tttattccca aaactctttt actgcttcga ttatctcact ataaggcaat
    71821 aaagtcgctt cgattattga tttatttgtc ttttctaaat aatacttaat catataatat
    71881 ccacaagcat atcctgcaca ataaggcaac cctactggaa aatatccttg cattttagct
    71941 atatcatcac cataaagata agatgttata ttttgaaatc cagtttcttt taaagcactt
    72001 tttattattg gctttatata agtatttaat gtttcgatat ctgttctact gacccaaggt
    72061 cctaacattt cctctccaaa catccatgtt gcaaaatttt ctgcaagacc ttcatttatc
    72121 atcatttctt ctaatgttat attattattc cactctataa actgaaatct aatattgtga
    72181 ttacattcat gtgctattaa tactggtaat ctattgatag tatattcatt aggaaccaat
    72241 gatagaaata tatatccagg aatcccacca tcaccccagt atccatcact taatattgta
    72301 taaggactat ttggattcgc caataatatt gaatatttat agtccttaat atttaaatca
    72361 tacccttctt ttataaaagc atttatagag ttttctatgg tttctttaca agtggcccaa
    72421 attttatcag cagataacac atttatattc tttttttgtt tttcatcaat atccttaggc
    72481 gataaaaccc ctaacatttc acttgctata attacatcat atccaccttt ctgtctagca
    72541 actattggaa cattcataca cttccactta aattcaaaag gcttcatcaa ttcatatctg
    72601 tatatatctt cttttttgtt tattggtgca tccattatct tcttgtatat tttatctgag
    72661 cgaatttcta taatattcat atttaccatc tcctttaaga caaagtatat acaattacgt
    72721 agcgtcaatg tcaatataca ttttttataa tgtcacctta atctttttat tatattttat
    72781 cctgtaaacc ttccgtacat ataacatttt tttaaattaa taaatttgta taatataata
    72841 ataaaaaatt atatacttca aggtttccct atgatacaat ttactaaatc ataatttaga
    72901 ttatcaggtg caactataaa ttattctata tcaaggagga tatattggtc atgctaactc
    72961 catatttaat atttaatggt acttgtgaaa aagcatttaa tttttatgct gaggctttcg
    73021 gaggaggaaa aactatattt gcgcgattag acagcaatcc aaacaatcct attatgcacg
    73081 caagtgttac tttcacaaaa tacgaaggtt gtataatggg tgcggataca gacaagcctg
    73141 ttgtaatttc tggcatggcg atttgtgttg ttctaccatc tcgagaagcg atagaagaaa
    73201 tatctgtaaa acttgccgaa ggtggtacac ttgtacaaga atttttacca cacccaccac
    73261 cacatcaaaa tgatggcgct gctgaagtac ttgataggta tgggtatact tggtatttaa
    73321 gtacatagtt aaaataaaaa aacgacatct aataatcata atatagaaca gataaatttc
    73381 aatttaatag tgtagtaaaa aagtcgtgtc ctaagactgt cacgactttt atttgtataa
    73441 aaatttaagt aaatattttt gcgaataaat gagaagtata actttaaatt aatttcatat
    73501 gtagtattgg aaatgggtta ccttgtccat ctatttcaga cctatcaaac actttaaatc
    73561 ctaagtgaat ataaaatcct acagcttttt tattctgctc atttacatca acatatttta
    73621 cattgtattt atctatagca tattttatta attttttacc aataccattt cctctatatt
    73681 tatcttctat aaagagcatc tcaattttat ctttatctat tcctataaag ccctttatta
    73741 tatcattatc ttttatacaa actatatttt ctacttcttt aagtccaatc tcaactaatg
    73801 gtatcaaaga ttcaatatct ttttctgtta aaaaatcatg cgttgctctt actgatgatt
    73861 cccagacttg caacatttcg tcatattctg ttgaatttat ttgtttcatt tcaagaatta
    73921 ttccagattt cataaaaatt tcctccctat atcactttta attgcataac acttttttat
    73981 acaaaactta gaaaggacta cgaaggttaa atatcatagt cctcattaag tttaaatatt
    74041 atctattata tattattata ctataatcta gcaaattcac tacaataatt cacatcagct
    74101 tatactaaag gtgcttctat ttgagtagta aaaaggaatt tatgacaatg accatcatta
    74161 acagtagttt ctccacatat taagtgaatg tgtttatcag ttccaggtat tctaattgct
    74221 ggccctgttg taacacatat cttatggaaa tggtcaagga aatctacatt atcatttatt
    74281 ttatgaacat gatttgtacc tccatttatt ggtatagctt caccagtaac ccctgctgca
    74341 cggtggttat gtctatcctc acattcttct gctaacttaa cactttctga atattcatga
    74401 acatgtgtca tttcctcata atcattatag cacttgttgc acttattgta tttataatca
    74461 tcatacacat aatctctttc acatttataa ttttgataac tcatttttat atctctccct
    74521 atattatatt aagaaattct tgtaaagaat ctctaatgta taatatgaat taaagtcaaa
    74581 aaagttcatg ttttgtaaaa ttatgtatta atttaattat ttttcccagt atttagggcg
    74641 tattagtgaa gctggtaact tcgtactaga atctcctttt gcagtattta cttgtaattg
    74701 tgttaaaaat atactatttt caagattagc acctctaata tcacaatctc ttaagtctgc
    74761 tcctattaaa tttgccccac tcaaatctgt atttcttaaa tttgctgcta ttagaaatct
    74821 acctcttaaa tctgctccta ttagatttat ttttctaagg tctgctccta ttaaatctat
    74881 atttttactt aattttttca tgtttttaag agtagaagtc ttgataaatg atttaacctt
    74941 tcccatcaca gactcactcg cttgtgataa taataaatta acctttattc tatgtgatat
    75001 gatatccaaa ttaattatct gttctgggct catattagtt atcttttcag tttcttcaat
    75061 tattaaatca atttttgatt tgattgtatc tgatatattt aatacagatg cttctttaag
    75121 ataccataac atttcatgta attgtctcat aattaaaaac acttcagaca tttgatttgt
    75181 tagttctgat gattgcatcc agtctatccc cttatatgtt acttgtgcta ctttttgacc
    75241 tgaaccaaaa caatcatatg cagtacaccc tttaaaacct cgcttcataa gactattatg
    75301 tacagaacat ttaaaatctg gttgtaaatt aatacagggt tttcctgatt ccttatcgat
    75361 aggaaatcca tctgaagcag aaaaataaag agctacacag caaagtccaa agcacttctt
    75421 acagtcaatc tttagctcct caaataactt attatcatat atatttttat gtatatctat
    75481 catatttttt ctcctcttaa actttatttt taatattata ttatctataa ctaaatgata
    75541 atcaagtccc ttatttaaca gttcttattc tttattataa tttaaggtat tatttattcc
    75601 aatagcatac ataagtttct ttatacttgt aacaatacct ttatactaag acttatttta
    75661 aatgtagcac tgtaataata aattgtttat atactcataa tgtatttgat aaattgtaaa
    75721 tctttataga agttgaaatt tttaatgatt ttagaatcaa gatataataa taaatacaat
    75781 ttataaaatc agaaatatat aaattaacta tacaaaccta aataacatag catttaaatt
    75841 tacaatttca gtataaatag tacaaagtat attaatttaa ataagattgg cttatttgta
    75901 gaggagagaa tattttggtg ttcaataaaa tttatattta ataaaaccat aagaaaatat
    75961 aaagataaat aaacaaactt ttattactta atagattctt atggttttat actgtactga
    76021 aaaacaataa acactacagc ttatttataa tattacgctt ttttaacaac agaagacttt
    76081 agcttcatag ctccaaaacc atctatctta cattctatat catgtccatc tgatgagtca
    76141 tggattaaac ggatattttt cacttttgtt ccaatcttta tagatgatga acttcctttt
    76201 actttaaggt ctctaattac tgtaacagaa tctccatcat ttaatacatt tccatttaca
    76261 tctttgataa tatttgaatc ttcttcagct cccaatccta atgcccactc atgagagcat
    76321 tctggacaaa ctaaaagagt tccatcttca taagtatatt ctgaattaca tttcgggcaa
    76381 tttggtaaat tttccatctt tatatgtcct ccatttgtta tttttagatt tcttattata
    76441 taaaatttct tttgagcctt tatgatatca tattatactt atatttacaa actactaatt
    76501 tacttaatgt ttaaattcta ttcgtattat tattaaactt gatttagctg taatctcttt
    76561 cttatattta ttatagttga tattattaca attttataac tctatctgcc tgctccgata
    76621 actctaaatc atgagttaca aatacgatag ttttaccatt cttatttaga cttttaagta
    76681 tatcaaatac tatgtctcta ttttttttat ctaaattacc tgtaggttca tctgcaaata
    76741 ttacttcaca ttcttttaat attactcttg ctaatgctac cctttgttgt tctcctccac
    76801 tcaattcgta tatctttttt ttattgtatt ttctaagacc tacagactca agtgcgtaat
    76861 ttattttttt attatggttg atattttttt gatactttaa agcaattttc aagttatttt
    76921 caacattttc attctcaatt aaagcataat tttgaaatag atagccataa aaatcccttt
    76981 gtaaaattct tatctgttta ctatttggat tttttatatt atttattata atatcaccag
    77041 aattaggttt ttctaataat cccattatat taagtaaagt tgtcttacct gaaccactat
    77101 ttcctgttat cgctacaaac tcgcccttag aaatttctag gttaaatttg tctattatag
    77161 atttatcttt aaatttttta gatatattta ttaatgaaat catcttttta atgttctcct
    77221 tttataattt tattaaatga actatttgag ataatcttgt ctaatacaat agatacaatt
    77281 acttctataa ctaatattag aagtccaaat aagataatat tattacttaa atctactctt
    77341 gttgatataa tgcctattgg aataatgttt gttaatatta atgagactat taacaacata
    77401 cttctagctg tagttgaata accaaatatt tttttaatat ataacttata tttatttctt
    77461 tcatagtagc tagctactat attgtaggta atcattaagt ttgatattgc tattattatt
    77521 atagtaaaaa tttcactatt caaatatttt tctagtttat ttatttctaa accatactca
    77581 ttataaacag catgtaaact ttggatatgc gcttctacac cttgagcttc aataatgcta
    77641 cttatatctg caagggcatc taatttctta gaattaaaat atacacatct agatatataa
    77701 gaaagataaa aagaatcatc aatattatct atgtcaacta ttgctattgg gtcatcaatg
    77761 agattcctat tgtcatccat aacaagggag ttataagtaa aatagctttg attattatct
    77821 acatatatta tattaacatt taaatctgac ttctttgttt tgtttaacgc tctatttaac
    77881 tctttattgt acatattttc tacttctatt ttttcaaaat aaaataattc tctaaactct
    77941 tttttaatct cattttcatg tacttgtaac tttttaggaa ctaataaatt tatagtctta
    78001 tcgtcataat cgattagatt aaatatttct ttgccatttg agtaaatagg gttaacttta
    78061 agatagtttt tatttatttt tatattttta ccatattgac ttacttctgg gtttttaccc
    78121 tttgaattta tttcatacat gtaacttcca tcttcaagtt tttcaaaatt agttgaatct
    78181 attaagaaag catctttttc ttctaccaaa tttttataga aacctttaat cttggcattt
    78241 ttaattactt cttcctttcc taaagattgt tcgcctgtat ctttaagagt aagattataa
    78301 acattttttg ctttatccca ctcagataga tttcctaact gagtttgtag catattataa
    78361 tttaaaatac agttatttat ggataatata agaaatgata caaatacaat tttcaatgtg
    78421 aaatgcatta tatttacaaa accataagat ttttttccat ttagagatag cacatattta
    78481 gaacttctac tattaaaacc aactattaat atagatatca aaatatttat caaaatacat
    78541 ataatcgaaa acatagcaaa gtataagcat gctctaacac ctatatttaa ttttaaaata
    78601 tagattatat atattaataa tgctgtgaca gatgataaaa tcataattct aagtatattt
    78661 tttataactc tagcaattat atctagctta gagtatccat ttaatcttaa aatagaagcc
    78721 tctctactca cactaattga ataatgtatt attgtagcca agaaacaaag gataattagt
    78781 attaaatctc taattattga aggatttaag tataaatttg agttaacata tctatcatgt
    78841 aatcttgcta caaaaatact tctgtctaca tttagttctc ttaatatttt atttattgta
    78901 tcttcatttt gagttgaaat atataagatt cctgattctc caacttcact tattttacca
    78961 aaatccctaa ttaaaattga tatgtcttta ctcatagttg agaatttacc tacttgatta
    79021 ctattattag tgtttatatt actaataaat tcatttgaat tagtattagg aaattttcct
    79081 gattttaact ttatattgtt attcaaactt gtatcagtcg tatatataga taatttttca
    79141 ttattattaa aaacatactt tgatatagtc acattatttt catctgcaat atctttaatc
    79201 cacttactat aatttttatt taacttttta taatctttaa acattacaga tat
//
LOCUS       DAEPID010000009        78215 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.009, whole genome shotgun sequence.
ACCESSION   DAEPID010000009 DAEPID010000000
VERSION     DAEPID010000009.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 78215)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 78215)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..78215
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.009"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            <1..995
                     /locus_tag="KR257_000687"
     CDS             <1..995
                     /locus_tag="KR257_000687"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903172.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=3
                     /transl_table=11
                     /product="GGDEF domain-containing protein"
                     /protein_id="HBH0029414.1"
                     /translation="EVYLEKIKNHSLKEVEKFDLFISLAMYYAKSNEKSFEQSICYLD
                     RAKNILNMIKNIEEYIIYDLEIIYHQAKIYYIFGYYDNALNTNKKLLEKSKNAKNYNY
                     VKLAYKSIYLCFEKIQNYEMSMKYFKMYYELKMMYIKARNRNYIDSLNYRHEYIEKEI
                     NNMRKVKLDLDKKKYVDHLTSAYNRTFLNDFLEKQEVSEYCTAFMIDVDYFKEYNDTY
                     GHYNGDIALKNITIIIKKYLKKDMLMIRYGGEEFLILSVCKDYKKSKIFGRKLCRIVK
                     KFLNNNLTVSIGIDTCKNSSIDIKEIIENADKALYKAKESGRNRCLHYHDFKNF"
     gene            1022..2908
                     /locus_tag="KR257_000688"
     CDS             1022..2908
                     /locus_tag="KR257_000688"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897561.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GGDEF domain-containing protein"
                     /protein_id="HBH0029415.1"
                     /translation="MKRSLIEDLKRNINKIEYDMLTKFYLNLTDLNYILDYHKDLLNT
                     KLEDNSRVYTLYLISLINYIKKDREASYNYLIESLKYIKKLSLKDDSDIISKIYIYLT
                     LSAISIRKYDKVNNFYFSAKKIIRQNHLNELLVLLNMSLCVEISALYQTKTDVIALVE
                     EVSFFKTLKNKALVSRANYIFGRVYLYLFNNFIKSMEYLIECLKLAQENNLYSIEAFC
                     KCIISLCYLESGNNVEAIKYINNVLDVAHSNNSISVTERVSIKIDLIWAYLKEDMNKE
                     AEVILLKTIKLMKVVEGVYKDYLYSFIFLYSAEIELKKDNCSFEKVNTYLILSKNIYK
                     SFGDVFIYNSKLDYIYKLYGDLYIKFGNIDEGISCYIKGLNLVKKSSLNLRKISIFYG
                     LIANGYELKKDFKLAIEYYKSMDWYSDRWEKNNSYKTSQAIHKQYELRQKQESLRLLV
                     DDNKKLENDILKDGLTKLYNRRYLEQQLDLFNETRDKNMVAILVDIDCFKSYNDNYGH
                     LAGDKVIVKVTDIIRSVFIDITEHIIRYGGEEILILVDSIESIGVEEIDNIELYIKRV
                     FKLLEFEGIEHIYSKIKNYITISAGVSIKRCRSRKDVEILIEDADKNLYKSKKAGRNQ
                     YIII"
     gene            2916..4916
                     /locus_tag="KR257_000689"
     CDS             2916..4916
                     /locus_tag="KR257_000689"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454679.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sigma 54-interacting transcriptional regulator"
                     /protein_id="HBH0029416.1"
                     /translation="MILLRKKIGIIASDIELKERIEELYREDVENGTIIIDILNLDLM
                     ENQGRILVEKGAQAIIGRGGGYSLVIDTVNVPVIPMNMKSTDLLRAIEIAKKYSKKVV
                     LILGDNEVSFDYVGWRNVISTEITEEWFESKYEIRSKVVKYIDQKDEIVIVGGGLACS
                     FARQYGIDSVFATASDESIREAVEYCKKLLDTLGEEKFNNEVLRNILDGIKDGVIAID
                     SNGSIILYNESAKNMLKVERKCALNKYILDVFPKMEWMLDCLHEKEDVEDRKIRNINN
                     LIVNTRTTLIKVDNSTYGVLGIIQDITKLQNLERKIRFDLNQKGLYARYTFDDFLFKD
                     KLTKEFIEEAKKIGKSDYTTLLYGESGSGKEIIAHSIHNISKRKDRPFVAINCATIAE
                     NLLESELFGYEEGAFTGARKGGKRGLFELAHGGTLFLDEINSLSFNIQTKLLRVIEER
                     QIMRIGSDYIIPLDIRIIAATNESLTEKIVMGTFRADLFYRLSSLEINIPPLRDRRED
                     IIPLFNNFVNEVLKDDGLNGINSIDENFVLTKDEMDKLYNYSWPGNVRELKTIAQKYV
                     VTGKIKLRQDRDFKTKKLLPNSEVDKFNSETTASVEVQDESINISKINDGKISIDIKE
                     VNKYVEEKIISMLFAQGLSKNEVAQVLGISRTSLWKKYNKNI"
     gene            5178..6437
                     /locus_tag="KR257_000690"
     CDS             5178..6437
                     /locus_tag="KR257_000690"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430809.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aminotransferase class I/II-fold pyridoxal
                     phosphate-dependent enzyme"
                     /protein_id="HBH0029417.1"
                     /translation="MSQSMVGKHAMWPKENDVIFSISGRAQAAEKAFGMDNVINATIG
                     ALMDDSGKLITMKTVYEEYKALDNCEIGAYAALEGQPDYLEAVKKVFFRDYLPEGHIR
                     VLASPGGSGAIKLAVWNYTNEGDEVLTSDWFWSPYVSIAEEANRKVVNYQLFDENRRF
                     NFESFKEKFVNIAEKQGRVFTIINTPAHNPTGYSVADDEWDKILDLSKEVAKDKDKKI
                     IFFVDSAYIDFAGDDDVCRKFFKKFSNLPENVLVLVGFSMSKGFTAYGMRMGAIICIS
                     SSEDVAEEFHYSCVHSCRANWSNCNRSAMAVLSNIVNDPKKFKEYEDEKEIYKNMLTR
                     RADVFVKEAERVGLEILPYIAGFFVSIPCDNPKEVCEELTKHNLFAVPLKMGLRFAVC
                     AVSEDKCKKAPSIIKEALESLEVKINN"
     gene            6498..8285
                     /gene="iorA"
                     /locus_tag="KR257_000691"
     CDS             6498..8285
                     /gene="iorA"
                     /locus_tag="KR257_000691"
                     /EC_number="1.2.7.8"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416787.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="indolepyruvate ferredoxin oxidoreductase subunit
                     alpha"
                     /protein_id="HBH0029418.1"
                     /translation="MKQLMTGNEAIARGAYEAGVKYASAYPGTPSTEILENIATYKDA
                     IVAEWAPNEKVALEAAIGGSIAGARTMASMKHVGLNVAADPIFTYAYTGVNGGMVLIT
                     ADEPGMHSSQNEQDNRMYAKFAKIPLFEPSTSQEAKDMIKEAFEVSEKYDTPVLYRVT
                     TRLCHSKGLVECYDREEVEIKEYVKNAKKMVTVPANAQIRRGVVEERMEILKKFSNET
                     DLNYYEINDTKIGVIASGMCCNFAKEVFGKNASYMKLGFTNPLPYEKIKEFAEKVDKI
                     YVIEENDPFIEEQIKAYGIDCIGKDVIPPYGEMTPDVLRKAIFGKTNDTIEYKSELVT
                     PRPPSFCAGCPHRGFFYELGKRKNLIVGGDIGCYTLGFAPPYNGIDYVVCMGSAFGTA
                     HGAQKVLNMKDDNEKRLVGVLGDSTFFHTGINGLLDVVYNRGNSISVILDNRITGMTG
                     HQENPGSGYTLQGAKTKEVDIEGLVKACGIEHVRVINPNNLKEVNEALDWALAIEDEP
                     SVIITRWPCVLKKFSKEDIEEFNNPFKTKCKVDHDKCIGCKLCLKTGCPALSFDKENK
                     LSNIDRNQCVGCGVCAQVCPKQAIVKEEK"
     gene            8287..8862
                     /locus_tag="KR257_000692"
     CDS             8287..8862
                     /locus_tag="KR257_000692"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430806.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="indolepyruvate oxidoreductase subunit beta"
                     /protein_id="HBH0029419.1"
                     /translation="MTKSILLVGVGGQGTILASKLLTMGLMEAGYDVKMSEIHGMSQR
                     GGSVSSQVRYGDCVHSPVIEIGGADILVSFEKMEALRWFNYLKPEGKALVNNHRIDSM
                     TVLIGGAEYQESDIDAELSRLNAKVINAADKAEELGNSKIMNVILLGCLVKSMQLESI
                     DWEKIISENVKPKFVELNIKAFHEGMEMVSK"
     gene            8915..9985
                     /gene="buk"
                     /locus_tag="KR257_000693"
     CDS             8915..9985
                     /gene="buk"
                     /locus_tag="KR257_000693"
                     /EC_number="2.7.2.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454677.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="butyrate kinase"
                     /protein_id="HBH0029420.1"
                     /translation="MTYRILAINPGSTSTKIAVYDGEEQILVKTIDHPAEEIAKYNTI
                     QDQFEMRKEAVLNILKENSIDLKSLSAIVGRGGVLPPVKSGAYLVNEEMIDVLRHRPV
                     LEHASNLGAVVAHAISEPLGINSYIYDSVAVDELIDVARISGLCGMDRSSAGHALNTR
                     AMALKYAKDKGKDYKSLNLIVAHIGGGVSIYLHEKGRMVDMLSDDEGPFSPERSGRVP
                     ATKLVAACYSGQYSEREMTKKIRGKGGIVSYLNTVDAREVEKMIAEGNEEAKIIYEAM
                     AYQLAKGIGELATVVDGKVDAIIITGGIAYSEMFTSMVKKKVEFIAPVEIMAGENELE
                     SLAFGTLRVLNGEEEARIYSEN"
     gene            10203..10904
                     /locus_tag="KR257_000694"
     CDS             10203..10904
                     /locus_tag="KR257_000694"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416796.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0029421.1"
                     /translation="MGKISLKSMIRLFSGFFIFAISSVLMINAHVGLMPWDVLHQGLS
                     IKLGITIGQASIMVGVVIVILDAVFGENIGWGTLLNMTFIGIFIDLVIFSGVIPHASN
                     TYIGVFMVVIGIILAAIASFLYLGVCLGSGPRDGLMIALQKKTNKSVRLVRTILEILA
                     LVVGWLLGGSVGIGTLVSALGLGYVLQIVFRIFKFDTKLLKHRFIIDDIREWKEKKSN
                     EHKCKSSIVIKNEQN"
     gene            10964..11470
                     /locus_tag="KR257_000695"
     CDS             10964..11470
                     /locus_tag="KR257_000695"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416798.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NUDIX domain-containing protein"
                     /protein_id="HBH0029422.1"
                     /translation="MELWDLYNADGIKTGNVIKRGNSIEEGYYHLAVEVWILNSNSQI
                     LIQKRSKSKKTLPNMWGMTTGCIVSGEDSLEGAIREAKEEIGIDITKDEMKVFRSMIH
                     EDTLWDVYLVKKEYDISKAILQEEEVSDIKWVSTDEIRQLLKEGLFFEYPEIYELLYE
                     IDNNKLNI"
     gene            11645..12667
                     /locus_tag="KR257_000696"
     CDS             11645..12667
                     /locus_tag="KR257_000696"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416801.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AI-2E family transporter"
                     /protein_id="HBH0029423.1"
                     /translation="MEDNKGLARDSSKYKIVSISVVVIILITFWYMLNMVLLTFIMTF
                     IFYNLLVATRKRIKKFSSLNIPDSLIIIVLYALFAILLVLISYAVVPIIIVQLTELSR
                     VFSDFDVNQFAQSLGPKLYPIVSKLDFNKYISQAGLLIASTATKVGSFGVNILLAFLL
                     SLLLLLEKNEIKNFGDKLSDSKISFIYNSLVFFGKSFVKNFGEVMKVQVMIAFINSVV
                     SMIFLGFMGFPQIWALGFMIFVLGLIPVAGVIVSLIPLTVIAFNTGGITKVFGVLLMI
                     CIVHAVETYILNPKLMSNRTKLPVCFVFIILLVGEHYLGVWGLLIGVPIFMFLMDILG
                     VKFTSR"
     gene            complement(12814..13122)
                     /locus_tag="KR257_000697"
     CDS             complement(12814..13122)
                     /locus_tag="KR257_000697"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430798.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1540 domain-containing protein"
                     /protein_id="HBH0029424.1"
                     /translation="MKNNNLNCAATNCAYNTSGYCYAGSIKVDGMQATTTENTYCASF
                     EDKYTSGITSRSNETNQVDTDNIHCEAVKCKYNKNELCKAEKVHINERNASCETFEMK
                     "
     gene            complement(13182..13610)
                     /locus_tag="KR257_000698"
     CDS             complement(13182..13610)
                     /locus_tag="KR257_000698"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430796.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0029425.1"
                     /translation="MNNKLHELEKNLPEISCSFCTHLSFKGPSLDYRYDIRCVISDTK
                     PDFRGCCEYFEPEYTELNTGDLDNLYINFLETCLKVNYNDYINSMYWKLFKERTLLEN
                     NFKCSICGSTENVDVYHVNKNLGRETSKDVVVKCDKCNCK"
     gene            complement(13833..15290)
                     /locus_tag="KR257_000699"
     CDS             complement(13833..15290)
                     /locus_tag="KR257_000699"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890565.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="carbon starvation protein A"
                     /protein_id="HBH0029426.1"
                     /translation="MTTFLIGLAILLIGGALYGAYCEKVFGPDDRKTPALAQSDGVDY
                     VPMKKWKNSLIELLNIAGTGPILGPIQGILFGPIAFILIPIGCVFGGALHDYMSGMIS
                     IREKGAQMPSLISRFLGNKVFQVYNIFLCLLMLLVGAVFIYTPGDLVVTQILNMKSTI
                     NNPVVWIVYGLIFLYYLCATLFPIDKIIGKVYPIFGAILLLSAAGVGIGIFTQGYDLA
                     NLSLANWKGIHPDGIPLIPTFFVTVACGIVSGFHSTQATLIARSVSNEKEGKTTFYNM
                     MILEGLIAMIWAAAAMGIYNKGIPKELVGSPDVIGLVARDLLGSIGGIIAIIGVIVLP
                     ITSGDTALRSLRLMLADYFHYDQKEKKHRVILSICIFIPVIAILIFAKLSASGFNILW
                     RYFSWSNQTIAIFAFAMITVYLIIKEKNYIISLIPGMFYSFVIFSYIFNAQIGFNLNI
                     NISYVLAAIFTVLYAILTVRSGRKLKSKADTKLAD"
     gene            15708..16622
                     /gene="nadA"
                     /locus_tag="KR257_000700"
     CDS             15708..16622
                     /gene="nadA"
                     /locus_tag="KR257_000700"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416811.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="quinolinate synthase NadA"
                     /protein_id="HBH0029427.1"
                     /translation="MDKDLTYQIKELKKEKNAIILAHFYQPPEIQELADAVGDSYYLS
                     EIARDCKEEVVVFCGVRFMGESAKILSPEKTVLMPVSNAGCAMADMVDEEGVIKLKQQ
                     YPNALVVCYINSTAKVKAHCDVSVTSSSAIKILENIDNKEIIFLPDKNLGGYIAEQFP
                     DKNFIFWDGYCKYHNNIRAEEIIELKDKYKNAEVLVHPECKKEIRDLGDYVGSTSGII
                     KYATNSKNKDFIIATEEGILHELKKNNPNKNFYIPGGKILCTDMKKTTLENLYSTLKN
                     MENEVIVEDEIMEKALNSLLNMHKLAEG"
     gene            16635..17936
                     /locus_tag="KR257_000701"
     CDS             16635..17936
                     /locus_tag="KR257_000701"
                     /EC_number="1.4.3.16"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903160.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="L-aspartate oxidase"
                     /protein_id="HBH0029428.1"
                     /translation="MNLEQDVLIVGSGVSGLYCALNLDKSLNVLVVSKSTIENNNTYL
                     AQGGISTARNIDDIESFVEDTMKAGQYKNRVEAVQVLADESIENVGQIVEYGMPLDKE
                     NGEIDYTREGAHSVNRIVHSKDNTGEVVFKTLLKEAKTRENITLIEDAYLLDILKDGN
                     KCIGARIFKSKKEIHVFSKIVVLATGGIGGLFKNSTNQRHLTGDGIAIALRNNIKIEN
                     LEYIQIHPTAFYEENNEGRRMLISESLRGEGAKLLNKNKERFVDELLPRDVVSKAIFE
                     QMEKDKLPYVYLDATHLDSEYLINRFSFIYNECLARGTDITKECIKVSPAQHYFMGGI
                     HVDLDSKTSMENLYAVGEISCTGVHGANRLASNSLLEGLVFSKRAAKNINSVIDNVKV
                     KFIDVPDMDIDIEQVKKENKILVIKEIERTSEDFGDELFDY"
     gene            17917..18753
                     /gene="nadC"
                     /locus_tag="KR257_000702"
     CDS             17917..18753
                     /gene="nadC"
                     /locus_tag="KR257_000702"
                     /EC_number="2.4.2.19"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454666.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="carboxylating nicotinate-nucleotide
                     diphosphorylase"
                     /protein_id="HBH0029429.1"
                     /translation="MNYLIIDRMIQDALIEDVPSEDITTNSIVDENSKSTVDLICKQD
                     GIIAGLGVFKRVFEILGDVDVKLYKNDGDRVKNREKIAVLTGSTRNLLVGERVALNYL
                     QRMSGIATITSRYVEKLEGTNTKLLDSRKTIPNLRILDKYSVKVGGGCNHRFNLSDGI
                     LLKDNHIGAAGSVKKAVELARKNTSFVRKIEVEVETLDMVKEAIEANADIIMLDNMSL
                     EMAKQAVDIINGRAIVEFSGNVNLDTIEDIGKIGVDVVSVGALTHSVKALDISMKNLR
                     NI"
     gene            19009..19341
                     /locus_tag="KR257_000703"
     CDS             19009..19341
                     /locus_tag="KR257_000703"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430785.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DsrE family protein"
                     /protein_id="HBH0029430.1"
                     /translation="MKVAYIFSSTNTHKILDKMIIPQLEQGTHGVDVLGMFFFMDNTL
                     FLSKGNPVGERLSKLHEKTDMIIMACDQCAIERGIENNLVDGATIGCFPNLYACLGSA
                     GVDQVITL"
     gene            19503..19688
                     /locus_tag="KR257_000704"
     CDS             19503..19688
                     /locus_tag="KR257_000704"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416821.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0029431.1"
                     /translation="MSEKYADKLEIKLYQAGKDFSYIKKYGIITKGTLIINQKKKYDR
                     LNKDTIERAIVEAINNN"
     gene            19715..20800
                     /locus_tag="KR257_000705"
     CDS             19715..20800
                     /locus_tag="KR257_000705"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416824.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="permease"
                     /protein_id="HBH0029432.1"
                     /translation="MNILEIVLNGVKDTIVASIVTLNGASGWLMISFILAGVLHNVLT
                     PRRFQKQLGNKKFSSLIKSTISGMFLPICSCGVIPLGISMYYSGAYLGPVLAFMTSTP
                     IINPIAVVLCLGLLGPKVTIIYLIAGFLVPFLVGFLGNCFGKEELSLHNDSEEEVIEL
                     EEEKRSFMENMIDGLKWSFGELALTISKYVVMGMVFAGFITTIFPNSIIQKYLGNPGL
                     LSLGSIAILACVMYVCAVGHIPFIAALVASGASPGIAITFLIAGAATNLPELISMFKL
                     IGKRTVIIYSVTLTLSSIIIGYITNLLLVNNNSVNLDATNSSIQLANKLMLNIPDSFE
                     YVCTILIILFAFKSIIPKMKEVIGNHA"
     gene            20793..21251
                     /locus_tag="KR257_000706"
     CDS             20793..21251
                     /locus_tag="KR257_000706"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430779.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0029433.1"
                     /translation="MLKKIVIISCIVVVLIILSKIVDDNIKEDASIPNVNKETLEYFR
                     KNYKEDIITCAEEDLNNDGKKDLVVIYKKSNNSNEMVVVVSDKNSHYITKPIPAPIEN
                     QTITFKNIDDKAPIEVIVSGSKNGNVGYAIYRVEGKKFVDLFGEDMDKCC"
     gene            21286..22377
                     /locus_tag="KR257_000707"
     CDS             21286..22377
                     /locus_tag="KR257_000707"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454662.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="HBH0029434.1"
                     /translation="MKLSKKIQALILFGVMGTSILTGCSSKPKEKEEAKTGKDDYTIT
                     VGYYNCDHMTAGPVAESAGIYKDLGLNVKTVGNGKVPEAMAAGKMDAGYIGTKGLVGA
                     IPKGSPITIAANNHTGGSEYLIVSKDIKEPKDLIGKKIATDMSDFLWTSDYGPETGLP
                     TDPSKYEVVNMDSDKDKYLALKTGKIQAFTSCDPWGSVAENDGAGKIIASTQYKEKAN
                     GKEYNCCSFSLNKNFIKEHPDLAKKLVLAHTKAIEYIYTNPAEAAKIFAKYYNVEEEV
                     ALRTIYKKTVGEGRTLTWKVTGEEYKNNLQMYKDLKALDDIPKYEDTIDTSLLDSCGA
                     DDFDKFIKEKVNPEFPEGMSYEDWKAKVL"
     gene            22382..22606
                     /locus_tag="KR257_000708"
     CDS             22382..22606
                     /locus_tag="KR257_000708"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454661.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0029435.1"
                     /translation="MENMKNIIILFIIILGSIFIIFFNFEDKEEIKGKLRIGVSDDTS
                     GFVINYMVNRDYFENIKVSDIMDIFTINDC"
     gene            22616..23179
                     /locus_tag="KR257_000709"
     CDS             22616..23179
                     /locus_tag="KR257_000709"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430776.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0029436.1"
                     /translation="MQWALSSEEIDIAIICKDAAKQYVNVNSGFEIVGTVVQNSDIFL
                     LSDNNPEKIGVIQNRDYQSELVKKYYKNVEVAPLLGTALAYGLESNLVDGVVIDCIKS
                     IGLEGKRKSTTKLGDYDTYVLVVSKEFKKSKAYSDFITLYNKSVDALKNKATFKKALK
                     EYRNIRNIDMEEISNWKLKFLKIKAID"
     gene            23140..23769
                     /locus_tag="KR257_000710"
     CDS             23140..23769
                     /locus_tag="KR257_000710"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416848.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBH0029437.1"
                     /translation="MEIKISKDKSDRLTKKKTDGSMDILYKIILLVIIFLVWHFAAKD
                     IGSSLLLPMPVDVIKGFFFCVTDAETVTNLFITLQRVLKGFMYALLFGLPIGFIMGFS
                     KTFERVLSPVVDSVRQVPIMAWVPLTIVWFGIGDGPTIFLIAFSGVFPIILNTIQGVR
                     AISKDYYNAARSMGASPIVIFTNVIVPASLPDILTGSRIAISTGWMSVI"
     gene            23946..24698
                     /locus_tag="KR257_000711"
     CDS             23946..24698
                     /locus_tag="KR257_000711"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430772.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBH0029438.1"
                     /translation="MKLSVRDINKTFVNNRVHTKVLEDISMDIDDGQFVCLLGPSGCG
                     KTTLLTIIGGFQKSERGDVFINDKRVKKPGIDRAFIFQNYALFPWKTIRGNVLFPMKQ
                     QKIPKEKREEMLEELLVMSDLKGKEKLFPHQLSGGMKQRVAMIRALACNPEVLLMDEP
                     LGAVDFQMRQNLQEELERIWIKKKITALMVTHDVDEAVYMSDRVIVMSRDKGRIIDDI
                     NIDIPRPRIRGSQKYEEYKNKLTDTLSKCYEV"
     gene            24711..25196
                     /locus_tag="KR257_000712"
     CDS             24711..25196
                     /locus_tag="KR257_000712"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890560.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0029439.1"
                     /translation="MSQIEKYNSLDNTQQKIRISIMDMIIDKGSSVTLQEVTEYISKK
                     LNIEKEYIERTLQYFIYKNIMVVDGNSINFIYPVSALPTNHKVTLRDNRSFSAMCAID
                     AIGTSCTFNQDIKINSICSATGKEIEVIIKNEKIEYVNNPNLRVLHINLDKHLNWAAS
                     C"
     gene            25203..25352
                     /locus_tag="KR257_000713"
     CDS             25203..25352
                     /locus_tag="KR257_000713"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454658.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0029440.1"
                     /translation="MNFFWTKSDFDAWTNEAGLSNDEDIYCLDINEAIVESYKIFKLK
                     QKVLS"
     gene            complement(25489..26310)
                     /gene="yidA"
                     /locus_tag="KR257_000714"
     CDS             complement(25489..26310)
                     /gene="yidA"
                     /locus_tag="KR257_000714"
                     /EC_number="3.1.3.23"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897541.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sugar-phosphatase"
                     /protein_id="HBH0029441.1"
                     /translation="MYKLIALDIDGTILNTQKRITPEVFESIQEAKRAGAKVVITTGR
                     PLPGVKELLNQLNLTDEGDYVICFNGAIIQEVKSEKIIHDVEMSLDDFDFIYNNVCKK
                     YKTKIHINTMTNLITPNETPGKYTLHEAKLNNIEVKYIQKDKIDESIKICKIMIVDEP
                     ERLEEIIQQLPKNLFNKYTIVRSAPFYLEFLGKTTNKGTALKTLCTNLNIPIENAIAV
                     GDEENDQHMIKYAGLGVAMGNARNSIKEIADYVTDTNNENGVAKVINKYILNKAI"
     gene            26803..28497
                     /locus_tag="KR257_000715"
     CDS             26803..28497
                     /locus_tag="KR257_000715"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454655.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="M3 family oligoendopeptidase"
                     /protein_id="HBH0029442.1"
                     /translation="MKFSEFKYERPNYNSMKKEFLSCVEDINNSRNYKEQQKNIHKIN
                     LLRNKIETLSNIASIRYSTDTFNKFYKEEKNYWDEYMPLYEELNSYFYNAIVNSKFKY
                     DLIKEFGEQFFTIVEYSLKSFSKEIISELQEENKLCSEYTRLLASAEIMFDGKIRNLS
                     GMGKFMYSKNRKTRELANKAYYNFFEENETKFDDIFDKLVKLRDKMSKKLGFEDFVEL
                     GYVRMMRSDYREYMIKNVRKQVLKYVVPMANELYEKQAKRIGLEYLSYIDEGVEFLTG
                     NASLKGDSRYIIKNGKRMYSELSKETNEFFDFMLENELMDLETKKGKGAGGYCTYIPD
                     YKSPFIFSNFNQTADDIDVLTHEAGHAFQLYMSRWIDMPEINFPTLDSCEIHSMSMEF
                     ITWPWMDLFFKEDTDKYKFTHLSSSIKFIPYGVIVDEFQHYIYKNPNVDKSKRKEIWR
                     FLEKKYLPHRKYGDNSFLERGCWWFKQGHIFKNPFYYIDYVLAQICALQFWKKMIQDR
                     DAGWKDYINICKVGGTKSFLDIVSMGNLYSPFDDGCIESIIGDVKSWFDEINDSKL"
     regulatory      28829..28939
                     /regulatory_class="riboswitch"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00504"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="glycine riboswitch; Derived by automated
                     computational analysis using gene prediction method:
                     cmsearch."
                     /bound_moiety="glycine"
                     /db_xref="RFAM:RF00504"
     gene            29043..29414
                     /locus_tag="KR257_000716"
     CDS             29043..29414
                     /locus_tag="KR257_000716"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903157.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GrdX family protein"
                     /protein_id="HBH0029443.1"
                     /translation="MIIITNNPKVKEEVQGREVLFKDTTYIGILEASRDLIHEGYELL
                     SHPLYGSVKPNETPYRTVILKKGNRLDINSLTLIEEAIITASKFQNNKKTPKWTESVQ
                     DDFRVIDYDIFYNTIQRMQYE"
     gene            29511..30458
                     /gene="trxB"
                     /locus_tag="KR257_000717"
     CDS             29511..30458
                     /gene="trxB"
                     /locus_tag="KR257_000717"
                     /EC_number="1.8.1.9"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416869.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="thioredoxin-disulfide reductase"
                     /protein_id="HBH0029444.1"
                     /translation="MENVYDLVIIGSGPAGLAAGLYGARAKLKTLILEKDKTGGQIVI
                     THEIANYPGSVPNATGPSLIARMVEQCKEFGAEMLRDNIVDTELDGDIKVLKGEKAEY
                     RAKAVIIGTGATPRKIGCPGEKELTGKGVSYCATCDADFFEDFEVFVVGGGDSALEEA
                     MYLTKFARKVTIVHRRQGFRCAKSVEEKAKANPKIEFLLDTVIEEIKGDGILESVVFK
                     NKVTGETHEYFADEEDGTMGVFVFVGLDAQTDLFKGKVDMDEKGYIITDEDMRTNIPG
                     VFAAGDCRSKTLRQVVTATNDGAIASIVAEKYIDEKFGN"
     gene            30562..30879
                     /locus_tag="KR257_000718"
     CDS             30562..30879
                     /locus_tag="KR257_000718"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416870.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="thiol reductase thioredoxin"
                     /protein_id="HBH0029445.1"
                     /translation="MLDLDKATFEEEVLNAEGFVFVDFWSEGCEPCKALMPDVHKLAE
                     TYGDKIKFCKMDTTKARRLAIKQKVLGLPTMAIYKDGEKVDEVTKDDATVPNIENMIK
                     KYL"
     gene            31148..32434
                     /locus_tag="KR257_000719"
     CDS             31148..32434
                     /locus_tag="KR257_000719"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006439082.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycine/sarcosine/betaine reductase component B
                     subunit"
                     /protein_id="HBH0029446.1"
                     /translation="MRLELGKIFIKDIQFGDVTEVKDGVLFINKQEMLQEIGGDEHIK
                     SIDIELARPGESVRITPVKDVIEPRVKVEGNGGIFPGIMSKVDTVGEGKTHALKGVAV
                     VTTGKIVGFQEGIIDMTGEGAKYTPFSKLNNVVVIAEPIDGLKQYAHEKAVRMIGFKA
                     AMYLGEVARNLTPDEVSVYETKPLLESIKEYPELPKVGYVYMLQTQGLLHDTYVYGVD
                     AKQIVPTLLYPTELMDGAIVSGNCVSACDKNPSYVHINNGVVEDLYARHGKDINFVGV
                     IITNENVYLADKERSSNWTSKLCKYLGLDAVIVSQEGFGNPDTDLIMNCKKIEMQGVK
                     TVIVTDEYAGRDGGSQSLADADVRADAVVTGGNANQVVVLPKLDKVIGHLEVVDVIAG
                     GSDGSLRADGTIEVEIQAITGATNETGFGHLTAKGY"
     gene            32546..33019
                     /locus_tag="KR257_000720"
     CDS             32546..33019
                     /locus_tag="KR257_000720"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011986236.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_except=(pos:32678..32680,aa:Sec)
                     /transl_table=11
                     /product="glycine/sarcosine/betaine reductase complex
                     selenoprotein A"
                     /protein_id="HBH0029447.1"
                     /translation="MSLLSNKKVLIIGDRDGIPGPAIEECVKTVEGAEVVFSSTECFV
                     UTAAGAMDLENQNRVKDAADKFGAENVVILLGAAEAEAAGLAAETVTAGDPTFAGPLA
                     GVALGLSVYHVVEEPIKSLFDESVYEDQISMMEMVLEVEEIEEEMSGIREEFCKF"
     gene            33051..34361
                     /gene="grdB"
                     /locus_tag="KR257_000721"
     CDS             33051..34361
                     /gene="grdB"
                     /locus_tag="KR257_000721"
                     /EC_number="1.21.4.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861534.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_except=(pos:34098..34100,aa:Sec)
                     /transl_table=11
                     /product="glycine reductase complex selenoprotein B"
                     /protein_id="HBH0029448.1"
                     /translation="MGKLKAVHYINQFFAGIGGEEKADTKPHVAETLPPISLQLDKLL
                     GEDIEIVGTVVCGDSYFNENIDSASEEVLSMVKGFEPQLFIAGPAFNAGRYGVAAGTI
                     TKVVKDALNIPALTGMYVENPGADMFKKDVYVVETSDSAAGMRKALPKIAKLAVKLAN
                     GEEIGTPKDEGYIARGIRVNYFHEDRGSKRAVDMLVKKIKGEPFETEYPMPNFDRVDP
                     SKAVKDLSKCKIALVTSGGIVPKGNPDRIESSSASKYGTYSIAGVMDLTEETYETAHG
                     GYDPVYANLDADRVLPVDVLRDLEKEGVIGKLHETFYTTVGNGTSVANSKKYASEIGA
                     ALVADGVDAVILTSTUGTCTRCGATMVKEIEKTGLPVVHMCTVVPISLTVGANRIVPT
                     IAIPHPLGNPALDPTEEKALRRGLVEKALNALTTEVDGQTVFEK"
     gene            34617..36149
                     /locus_tag="KR257_000722"
     CDS             34617..36149
                     /locus_tag="KR257_000722"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014520415.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ketoacyl-ACP synthase III family protein"
                     /protein_id="HBH0029449.1"
                     /translation="MTYPVLKGAGYVLIHTPDMIVQNGSTCTVERATNPDSEFLKEVS
                     NHIRSYEDVVNYMPNQVYIGNRRPEELRDLPMPWCEQKIEGTRNGKFGEIMPQDEFIA
                     LMQISDAFDLVKLSQEFIDEVKPKIENNYPEIAPFVGKLKGDDIEEGKELVATHIAEG
                     LYHDGKFVGYVKRAHDVDVNLNAHTMFENLVVKASGVLSAIQMLRHSKIDPAEIDYVI
                     ECSEEACGDINQRGGGNFAKSIAEIAGLQNATGSDTRGFCAAPTHALIQAAALVKAGI
                     HKNVMVVAGGASAKLGMNAKDHVKKGLPVLEDVVGGFAVLVSENDGVNPVIRTDLTGK
                     HTVGTGSSPQAVMTALITSGLDRANLKITDVDVYSVEMQNPDITKPAGAGDVPEANYK
                     MIGALAVKRGDLEKKELKDFVSNKGLPGWAPTQGHIPSGAPYIGFLIDDLTTGNRNRA
                     MIVGKGSLFLGRMTNLFDGVSFIAERNTGVTEETSGISKDEIKKIIAESMKKLALDML
                     EE"
     gene            36160..37305
                     /locus_tag="KR257_000723"
     CDS             36160..37305
                     /locus_tag="KR257_000723"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903155.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycine reductase"
                     /protein_id="HBH0029450.1"
                     /translation="MSKKVIADVFLEVANAIESGEFGKKVKIGVTTLGSEHGVENMVN
                     GAQLAKSNLFDIVLIGPKVETDLEVVEVNDEKEMHAKMEELLDSGYIDACVTMHYNFP
                     IGVSTVGRVITPAKGKEMILATTTGTSATNRIEAMVRNAIYGIATAKSMGNKCPKVGI
                     LNVDGARQVEKCLKELKDNGYDMEFADSIRADGGCVMRGNDLLVGAPDVMVTDTLSGN
                     IFMKVFSSYTTGGDYEAQGFGYGPGVGEDYDRKVLIVSRASGSPVVANALKYAYDVVK
                     GDISNVARNEFAKVKKAKFDDIISSLTKKEVKAEKVEVKMPDKEIVTRQIAGVDIMDL
                     EDAVSELWKNGIYAESGMGCTGPIVLVNEAKGDLAVETLVKAGYTAK"
     gene            37615..38694
                     /locus_tag="KR257_000724"
     CDS             37615..38694
                     /locus_tag="KR257_000724"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430749.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aminopeptidase P family protein"
                     /protein_id="HBH0029451.1"
                     /translation="MSRVKNVVELLETKGVDALYLTKKTNVNYISGFPDEEAYAVICK
                     DGNFLVTDSRYMELAEKVCKDFEIINWHNFDRSVAKAVKSVCDKVGIKKLGFERTNIV
                     FDKYEELKNLIEKDNGELIPTENIVETLRYVKDKDEIKNTRKACEIADKALEELIPHI
                     KAGVSEIELATRLEYFMKMNGAQNIGFETILISGAKTSLLHGKPSDKIIEKGDFVLID
                     YGAMYNGYISDTTRTFIVGGASEKQLEIYNLVKEAQNVGVENMKAGVHATIPDAEIRK
                     VVKKYEDYYYQGIGHGVGRDVHEEPFIGNYGDKIIEEGCIITMEPGIYFPGWGGVRIE
                     DTVLITKNGPERLTKFPKDLMILDK"
     gene            38807..39406
                     /locus_tag="KR257_000725"
     CDS             38807..39406
                     /locus_tag="KR257_000725"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903154.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0029452.1"
                     /translation="MYKKHKFIKNIKKAWYKIKLIDRCLIIVMAILMFQSIYNLFVNE
                     VNSQDTTTIDVVVRTTSAAIFGYFLSANFIKRPLRKYTNTDVSSNLFIDNNLSPKGQE
                     SNQNNIMNVKNTIGFTSEADNYEKKIPINNNEGFEEGETSELQIIIATVICIVALTVL
                     FVVRNFTTTTSASLGTISQMRDFVSGCVGFLLGCPSKPD"
     gene            complement(39593..40465)
                     /locus_tag="KR257_000726"
     CDS             complement(39593..40465)
                     /locus_tag="KR257_000726"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893591.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LysR family transcriptional regulator"
                     /protein_id="HBH0029453.1"
                     /translation="MNINYLYYFQTVCKYKNMTKAAESIHISQPSITLAIKELEKELG
                     FELFYRIGNKIELTPEGKIFLDKSKHFIKQFEDFQCDALDLGKKRKASLKIGIPTVLG
                     TFLLSKILPRFNVIYPDIELKIFEVPTFVGAKMIEESTLDFCIGIIDSDIYDDIDSKT
                     IYKTELYLVTNPKNELAKHPIISNYMLKNVPFVILSEGSYHYKIITKRLEKAKPNIIL
                     HSNQLSTIRYLLENDLASTILYKEIFQNTENLCSIPLERAITANIGVLWRRNQYISHS
                     MKLFIEYMASIHIN"
     gene            40882..42285
                     /locus_tag="KR257_000727"
     CDS             40882..42285
                     /locus_tag="KR257_000727"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430743.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0029454.1"
                     /translation="MKGSDLVKFELMDFLMNPFVLMFAAVITGILFGKIKFGKFNFGV
                     SGALFTGLFIGWLAYSLGNLIIAKGETAAGYKAATVMMGNGIISSDFFDFFLIIFVAA
                     VGLLAAKDMKAVLKKYGARFVILGVLITFIGGSMTYAMTLLSSDKGSSAYEVSGVYTG
                     ALTSSPGLAAALETAGKHAEDVSKEFEKASIKDKKEILKVVDPEGKLDVNTTTSLTQE
                     QIDKYIAYAEAGVGIGHAVAYPFGVLIVILGVNFLPKLFRMDLKEERRKYEKEMKEAR
                     DSVSGKTIPEVPFNIITFFLTCLAGYLVGGIHVFMGPLGYFTLGATGGSLIVSLVLGY
                     IGKIGVVNFRMEEKVLNILKQIGLVFFLAIVGLRYGGKVVDSIMTSGMHLALVAIAVG
                     VTAMMIGFLVGKYVFKLNWILLSGAVCGGMTSTPGLGAAVDALDSDDPAAGYGATYPF
                     ALLTKVILVIVLHKLPM"
     gene            42312..43856
                     /locus_tag="KR257_000728"
     CDS             42312..43856
                     /locus_tag="KR257_000728"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861532.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="acetyl-CoA hydrolase/transferase family protein"
                     /protein_id="HBH0029455.1"
                     /translation="MNNEGAFEELSGRLRNKELCDLIMNADEAAKIIEDGMVIGVSGF
                     TPSGYPKAVPLAVSERAKSGEKIKLTVYSGASLGPEVDGAWSEAGIIERRLPYQTNSI
                     LRNNINKGVVDYIDMHLSHSTQFLNYGTIPKVDVAIVEALAITEEGNIIPTSGIGNSP
                     SFIKSADKVIVEINLAKPMEMEGMADIYITENPPNRKPIEINHPKDRIGTTYIPCGLD
                     KIAGVVITNMQDKTRPLGVVDEASKKISNNIIAFLREEVKSGRLSKNLLPLQSGVGSV
                     ANAVLYGLCESEFENLTCYTEVVQDSMLDLIRMGKVTMASTTSVSPSPEGLIKFEKDI
                     DFFKDKIILRPQEISNNPEIARRIGVIAMNTAIEVDIYGNVNSTHIMGSKMMNGIGGS
                     GDFARNGAITIFSTESIAKNGDISSIVPMVSHVDHTEHDVMVIVTEQGYADLRGLAPR
                     ERAIKIIENCAHPDYKEQLRDYLNRACKSGAKQTPHILDEALSWHSKFMSTGTMKKAE
                     TFKSAL"
     gene            43887..45278
                     /locus_tag="KR257_000729"
     CDS             43887..45278
                     /locus_tag="KR257_000729"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454646.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aldehyde dehydrogenase family protein"
                     /protein_id="HBH0029456.1"
                     /translation="MEKAVENFEDLSKEYINGYIERARKAQREFECYTQEQVDKIVKI
                     VGKVVYYNAEYLAKLAVEETGMGVYEDKVAKNKSKAKVIYNNLKDKKSVGIIDIDRET
                     GITKVAKPVGVVAAITPCTNPIVTPMSNAMFALKGRNAIIITPHHKAIGCSTKTVEMI
                     NEELEKIGAPENLIQILDQQSRENTRNLISSADVVIATGGMGMVKAAYSSGKPALGVG
                     AGNVQCIIDRDVDIKEAVPKIIAGRIFDNGIICSGEQSVIVAEEMFDKIMDEFKNNKG
                     FIVRDKVQKEAFRNAMFVNKSMNKDAVGQSVHTIAKIAGVEIPEDTKIIVIEADGPGE
                     EDIIAKEKMCPVISAYKYKSFEEGVAIAKANLNVEGKGHSVSIHSNTVKNIEYAGENI
                     EVSRFVINQCCATSAGGSFFNGLAPTNTLGCGSWGNNSISENLDYKHLINISRIAYYM
                     PENEVPTDEELWG"
     gene            45471..46967
                     /gene="abfD"
                     /locus_tag="KR257_000730"
     CDS             45471..46967
                     /gene="abfD"
                     /locus_tag="KR257_000730"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430738.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="4-hydroxybutyryl-CoA
                     dehydratase/vinylacetyl-CoA-Delta-isomerase"
                     /protein_id="HBH0029457.1"
                     /translation="MALMTGAQYIESLRKLNTKVYMFGEEVKNWVDHPMIRPSINCVA
                     ATYDLAHDPEYADLMTVTSNITGEKINRFGHLHQSVDDLIKKVKMQRLCGQKTASCFQ
                     RCVGMDAFNAVYSTTFECDKAHGTNYHDNFVKYLTYIQENDLVVDGAMTDPKGDRSLS
                     PSAQPDPDMFLHIVERREDGIIVRGAKAHQTGSINSHEHLIMPTISMTEADKDYAVSF
                     AVPSDAEGVFMIYGRQSCDTRKLEEGADVDLGNKEFGGQEALVVFDNVFVPNDRIFLC
                     GEWDFSGMLVERFAGYHRQSYGGCKVGVGDVIIGAAALAADYNGANKASHIKDKLIEM
                     THLNESLYCCGIACSSEGHKTEAGNYQIDLLLANVCKQNVTRFPYEIVRLAEDIAGGL
                     MVTMPSEKDFKSDLKVGTSGMTIGEVCNKYFKASSVASTEERMRILRFLENICLGSSA
                     VGYRTESMHGAGSPQAQRIMISRQGNINQKKELAKKIAGIKKEEALNL"
     gene            47102..47377
                     /locus_tag="KR257_000731"
     CDS             47102..47377
                     /locus_tag="KR257_000731"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430736.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0029458.1"
                     /translation="MTCGVRFCGGCNPRYERGKALTIIKEHFNGRVDFSIAQENVEYD
                     LLLIIGGCATLCASYQQYKVKNECVKMWDFSHIERVINVIESAICET"
     gene            47401..48708
                     /locus_tag="KR257_000732"
     CDS             47401..48708
                     /locus_tag="KR257_000732"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454645.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="acetyl-CoA hydrolase/transferase family protein"
                     /protein_id="HBH0029459.1"
                     /translation="MSWQELYQSKLCSATEAVKQIKNGDTVVFAHCVGEPPALVEAMI
                     ENAEQYKDVEIKHMVSLGSGGYTAKGMEAHFRVNPMFVSGNVRKAIENGDGDFTPAFF
                     HEVPKLLREKRLKCDVVLAQVTPPDEHGYCSLGTSVDYTYEAIKTARTVIVQVNDQFP
                     RTYGEVVHVSEFDYIVEKSQPLFELQPAKIGEVEEAIGKNCASLIEDGSTLQLGIGGI
                     PDAVMLFLTDKKDLGIHSEMISDGTLALYEKGVINGKYKNFDKEKMTVTFLMGTKKLY
                     DFANNNPAVEVKPVDYVNHPAIIMKQHKMVSINSAIQVDLMGQVVAEAMGLRQFSGVG
                     GQVDFIRGVSMGEDGKAIIAMPSITTKKDGTVISKIVSIVDEGAPITTSRNDVDYIVT
                     EYGIAELKGKSLRERARNLINIAHPSVRESLAVEFEKRFKEKY"
     gene            48728..49846
                     /locus_tag="KR257_000733"
     CDS             48728..49846
                     /locus_tag="KR257_000733"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903149.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="4-hydroxybutyrate dehydrogenase"
                     /protein_id="HBH0029460.1"
                     /translation="MEALRVVPKIFYFDTFKEFNEEFKIGKNDLVITNEFIYEPYMKP
                     LGIDTNLIFQEKFGTGEPSDEMIDSMTKEMKKYNFDRIIAFGGGTIVDICKILALDVP
                     EKSIDLFEGEVSPKKVKELVVVPTTCGTGSEVTNVAIAELKSKHTKKGLAVEETYADY
                     AVLIPETVKGLPYKFFVTSSVDALIHAIESYLSPKASPFTEMYSLQAIKMIMDGYKKI
                     VDKGEEERFNHLRDFVLASNYAGIAFGNAGCAAVHALSYSIGGAFHVAHGEANYQFFT
                     EVFKMYSRKKPNGKIIKCTKILADALECDPNCDVYGELEKFLNKLIAKKALREYGMVE
                     SQIDEFTDSTIANQQRLLANNYVELSREEIREIFANLY"
     gene            50133..51053
                     /locus_tag="KR257_000734"
     CDS             50133..51053
                     /locus_tag="KR257_000734"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430730.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="5-bromo-4-chloroindolyl phosphate hydrolysis
                     family protein"
                     /protein_id="HBH0029461.1"
                     /translation="MYKSENFSKKSVLINSFLSKFLKIIGWGLVSLFTLSALVLSTIS
                     IIIGWAVILPIQVCAVFLLIGGVCIFKGKRLGDQISRYKKYCTIINNRNIIPVELIAE
                     NTSKSLNFIIKDVQKMIDKNYFINTYIDKRNNQIVLTNEDFVPPRYEDVAYEVKEEEK
                     TDESNEVDTIINKGMNYLTQIKEANKNIKSESMGDKIVQVEDVTSKIFDVVKHDPSKL
                     TQIQKFMDYYLPTTLKLLNSYHTLEEQGIDRENITTTMESIENTMNTIVVAFENQLDY
                     LFEDEAIDISTDITVLENMLVQEGLTSGKF"
     gene            51168..52325
                     /locus_tag="KR257_000735"
     CDS             51168..52325
                     /locus_tag="KR257_000735"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454642.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="toxic anion resistance protein"
                     /protein_id="HBH0029462.1"
                     /translation="MNNLDDIPVMPTLTLDPFGEESNTNDIDNSDLLMKKDEKDPEEE
                     KLSESERKMVKEFAEKIDITNTNMILQYGAGAQKKVASFSETALKSVKTRDLGEVGDM
                     LTNLVTDLKAFSADEKEQSGFLGIFKKANNKISNLKTKYDSAEVNVDKVSKELQKHQV
                     KILKDIAMLDKMYELNLAYSKELTMYIIAGKQKLKDMKEYEMPKLREKARLSGSTEDA
                     QSVNDMVSLCDRFEKKIHDLELTRMVSLQMAPQIRLVQNSNNLMAEKIQSTIVNTIPL
                     WKNQIVLALGISHLNQAMKAQREVSNMTNELLLKNAETLKMGTIETAKESERGIVDID
                     TIKKTNQSLISTIDEVVKIQHDGRIKRQEAEVELSKIENELKSKLLEFTVK"
     gene            complement(52406..53302)
                     /locus_tag="KR257_000736"
     CDS             complement(52406..53302)
                     /locus_tag="KR257_000736"
                     /inference="COORDINATES: protein motif:HMM:NF033516.0"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS3 family transposase"
                     /protein_id="HBH0029463.1"
                     /translation="MLKKVKYPIGQVKVSDKFKTIKLLSRKYSISSMCKLISVSRSGY
                     YKWLSYSKKSSDRGIKDRIIKDYIIEIHKKYRGTYGRKRICTYLNKILDTPINHKRVY
                     RLMKELGIKSIIRKKVYRRKFKSYEIYDNILNREFRANQPLEKICMDITYIPIGKKFL
                     YMNVAKDLFNGEIVAYEISTKMDTKLVNNTVNQLINMNLAKDCILHTDQGSQYTSRSY
                     SKRLKDNGIIQSMSRRGNCWDNAPIESFFSHFKSELIYLIDTTDPKEMISLINDYIYF
                     YNNERIQLKNGMSPIEYRTHSE"
     gene            complement(53260..53577)
                     /locus_tag="KR257_000737"
     CDS             complement(53260..53577)
                     /locus_tag="KR257_000737"
                     /inference="COORDINATES: protein motif:HMM:NF013677.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
                     /protein_id="HBH0029464.1"
                     /translation="MSKKHKKYSKELKLKAVNLYIKEGYSSYKIAEMLNIRSKTQVQN
                     WVKDYKNKGKTAFDDETRGRFKNISLENDNRKFKSVEEELKYLRMENEFLKKLSTLLD
                     KSK"
     gene            complement(53714..55213)
                     /locus_tag="KR257_000738"
     CDS             complement(53714..55213)
                     /locus_tag="KR257_000738"
                     /EC_number="1.1.1.205"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430726.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IMP dehydrogenase"
                     /protein_id="HBH0029465.1"
                     /translation="MAFYFDTPSHTFSEYLLVPGFSSTDCIPANVSLKTPVTKFKKGE
                     EADIYMNIPLTSAIMQSVSDDKMAIALAKEGGISFIYGSQTIEDEAAMVARVKSHKAG
                     FVVSDSNIKPDNTLKDILDLKEKTGHSTVAVTEDGTSTGKLLGIVASRDYRISRMDLD
                     TKVSEFMTPMSSIVYANKDVTLKEANNIIWDHKLNSLPVLDDNGNLMYMVFRKDYSSH
                     KENPLELLDSSKRYVVGAGINTRDFAERVPALVEAGADVLCIDSSEGFSEWQKITLDF
                     IREKYGDTVKVGAGNVVDREGFLYLAEAGADFVKVGIGGGSICITREQKGIGRGQATS
                     IIEVAQARDEYFEKTGIYIPICSDGGIVYDHHITLALAMGADFIMLGRYFSRFDESPT
                     NKVNINGSYMKEYWGEGSARARNWQRYDLGGDKKLSFEEGVDSYVPYAGSLKDNVTLS
                     LSKVRSTMCNCGALSIPELQKNAKLTLVSSTSIVEGGAHDVMLKDNRNL"
     gene            55809..57233
                     /locus_tag="KR257_000739"
     CDS             55809..57233
                     /locus_tag="KR257_000739"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454640.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS mannitol transporter subunit IICB"
                     /protein_id="HBH0029466.1"
                     /translation="MSSSNQSTIKTSIQRVGKFLSGMVMPNIGAFIAWGLITALFIPT
                     GWMPNEKLSTIGDPMIKYLLPLLIAYTGGKAIAGQRGGVIGAAAAMGVIVGADIPMFI
                     GAMIMGPFAGWVIKKFDKFVDGKIPTGFEMLVNNFSIGIIGMLLAILGFYAIGPAIVA
                     GTALIESGVQFIVSKSLLPLVSVFIEPGKVLFLNNAINHGILGPIGIAEAKEAGKSIM
                     FLLESNPGPGLGVLLAYWMFSRGSVKQSAPGAVIIHFFGGIHEIYFPYILMNPVLILA
                     TMAGGAAGILTFSILGAGLVAAPSPGSIFALMALAPKGGLLPVLAGVAVATVVSFLVA
                     APFVKRASANESEEDSTSLEEAKAKMSDMKSASKNSEKNIEKKQLEVNEIKKIVFACD
                     AGMGSSAMGASRFKNRIKNLDLDIEITNSSVDNLPDDTQIVVTHNTLVERVAKNNSSV
                     EIVSINNFLNDPNLDTLFKRLESK"
     gene            57268..59397
                     /locus_tag="KR257_000740"
     CDS             57268..59397
                     /locus_tag="KR257_000740"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009905855.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="BglG family transcription antiterminator"
                     /protein_id="HBH0029467.1"
                     /translation="MKKKKITSRQKKIILMIVENSKKNIPITISEIAGTLELSSRTVL
                     RDMSGIEKWFDENDFNFVKKPGVGLILEENIENQNFIIELLEEEKIEKEYSKEERNLI
                     ILSKLLVSNEPVKSYYFAKILKVSEGVLNNDFSLASKWLERFDIELVRKPGLGVYLKG
                     QEKSFREAYVNLIYDSFNEKEILDMVRNISENIQTDKAIEILSENRLLNLMDRCIIIK
                     VEATLTKKLSDLDVNLADSAYIGLVVHISLALQRIKNGENITMDKEFLKELSITEEFK
                     LAKEIVKGMETDFNMDIPVDEVGYITMHIRGAKQRSSSNHKALNLDDIEIMEITNKMI
                     DLAEDEFKISLKNDERLFKDLANHLGPSINRLNMGLEIRNPLLDEIKSKYSYAYDGVE
                     KISRIIKDKLNINSIPESEIGYIAMHFASAIEKNLMMNTNINIVVACPTGIGTSRFLS
                     TKIENKFPNLNILETISAINIDEEYLKGKDVDLIVSTVELNTSLNYICVGPFMSLDDE
                     QIIKEKIKSIAQNKLINLNTKNDTKSKNKVYEQITESMNIGKDILQFLEEIRFEKFES
                     KDLSELIEDSSKIFAKSSEDIMSIKESLKERLKISIPYIEESKILLLHCMSERIDIMK
                     LSIIKLENRIVLDSNEEIDNVVFMLLPKNSPSYQRQIMSEISGSLIDNIIFTNKINKF
                     SIEEMTLEVKDIVFNFYTNRLKAFIDE"
     gene            59427..59849
                     /locus_tag="KR257_000741"
     CDS             59427..59849
                     /locus_tag="KR257_000741"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430721.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIA"
                     /protein_id="HBH0029468.1"
                     /translation="MSKVLNENNIFLGLDSVSKEEAITLAGRKLVENGYVKEEYIPAM
                     LEREKVMTTYMGMGVAIPHGVNEAKKEILSSGIVILQFPNGIDFDGEKAYLLIGIAGV
                     GDEHLEILSNIAVVLDDDLTERLKNSNDKQAFMEAFAK"
     gene            59868..61019
                     /locus_tag="KR257_000742"
     CDS             59868..61019
                     /locus_tag="KR257_000742"
                     /EC_number="1.1.1.17"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897524.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="mannitol-1-phosphate 5-dehydrogenase"
                     /protein_id="HBH0029469.1"
                     /translation="MKKAIQFGAGNIGRGFIGGLLVKSGYHVVFADVNEEILNSINKD
                     KKYTIHIRDVECIDEVIDNISAVSSIKEEIIDEIVQAEIITTAVGPLVLTKIASTIAK
                     GIKARKEKGLTSNLNIIACENAIYASSSLKEEVLKYLNKEEVEYLEIYVGFPNCSVDR
                     IVPPGKNENPLDVTVENFYEWNVEKQGFKGEIPTIVGMNLADNLMAYIERKLFTLNTG
                     HAITAYIGYLKGYKTIEESIKDKFICDIVKSAMVESGEGLIKKYNFDSEAHYKYIDKI
                     LNRFKNPYLNDDVLRVGREPLRKLSDKDRLIKPLMTAKSYGLSVDNLILGIGAALHYN
                     NSEDTQSVELQELIKSNGVKKAVAKIANISNDEELLNNIEKSYIFMKNL"
     regulatory      61125..61226
                     /regulatory_class="riboswitch"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00167"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="purine riboswitch; Derived by automated
                     computational analysis using gene prediction method:
                     cmsearch."
                     /bound_moiety="guanine and/or adenine"
                     /db_xref="RFAM:RF00167"
     gene            61409..61981
                     /locus_tag="KR257_000743"
     CDS             61409..61981
                     /locus_tag="KR257_000743"
                     /EC_number="2.4.2.22"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423114.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="xanthine phosphoribosyltransferase"
                     /protein_id="HBH0029470.1"
                     /translation="MKALQEKILREGSVSGNDILKVDSFLNHQIDVAFLNEIGREFKE
                     RFKEEKVDKIFTIEASGIAIASIVSQYFDNAPVVFAKKSESKNLDKDVYETNVYSFTK
                     AREYSVKVSKKYINKGENILIVDDFLANGRAALGLKDLIEQAEANLVGVGIVIEKGFQ
                     AGGALLKANDVRLESLAVVESIDNGTVKFR"
     gene            62045..62695
                     /gene="fsa"
                     /locus_tag="KR257_000744"
     CDS             62045..62695
                     /gene="fsa"
                     /locus_tag="KR257_000744"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423115.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="fructose-6-phosphate aldolase"
                     /protein_id="HBH0029471.1"
                     /translation="MIFFIDTANIEEIKEANDLGVICGVTTNPSLIAKEGRDFIEVVK
                     EISEIVDGPISAEVISLEHEGMIEEAEKLSKIHKNIVIKIPMTAEGLKAVKVLSSKGI
                     KTNVTLIFSAGQALLAARAGATYVSPFVGRLDDISQNGLDLIEEIVDIFSVNSIEAQI
                     IVASVRNPIHVLQAARMGADIATVPLKVINQMIKHPLTDKGIDSFMKDWEGASLKL"
     gene            62847..65771
                     /locus_tag="KR257_000745"
     CDS             62847..65771
                     /locus_tag="KR257_000745"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897518.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sigma 54-interacting transcriptional regulator"
                     /protein_id="HBH0029472.1"
                     /translation="MDKILREIQREDKKNPYTDQELAEMLNVARSEVISVRKKNNILD
                     SRERRKKILIKDISKIVSENPQMSERKITEILIENGYNISRSAVSKLLKEENLNQSKI
                     GIKDKEPASSGKYVKVSKVVEEDGFEELIGIKGSLKEKVNLAKSAIMYPPNGLHTIIY
                     GETGVGKSELATCMYKYAIKNNIKEENSPFIVFNCADYAENPNLLIAQLFGVVKGAYT
                     GADANREGLVEQANNGILFLDEIHRLPAAGQEILFSLIDRGEFRRLGESSSNRKANVL
                     IISATTENPDSNLLQTFRRRIPMVINLPNMSERPKSERYEIIIKFFEREAKRVNKNFI
                     ITKEVMCALMNYKCTGNIGQLKSDIQVTCARAFSKSIFSSDKVIIDLDSLRDYIKSGY
                     YDCNCKNEKYSEFSVEDIYIDISELVSGKNRMLSDNEISEIYNYAEKELKVLESKCFS
                     EEELKNAFIEKLDKKFNAIKNNKNLSDRRSRIDWGGQLKESTLEIMDKVIVFIKEQFK
                     HVNQGLYLALAIHIEHAIGRIKDGKTIINPSLDKIKASMPMEYELSRYIMGIVEDLTQ
                     VTFPEDELGYLAYYINKFCYNEESIKDKVKVVIVTHGKVGIEMSKVVNHILGIECTLG
                     IEIALTDSPSEGIEHVLEELQKIEARKGILVLIDMGSLVILGDEVEKRLGIRCKTVNR
                     VDTLLAMEAGKLATIEGKSLDGIIADLKKNKNYAMINTNKFSYRKNEYGKKNVIITLC
                     LSGVGTALNLKEHIEKQIKEYDTLIEVKPVAFLNNNLEEELNDIEAEYNIIAICGTID
                     IDYKNVPFISYNEVLGKNGINKVLEHLNSKQPVLNIENQLNNLIHEDLILYNFEGISK
                     EYIIDTLVSKLEEGGYVDSKYILSVYKREAMGSVVMASKVAVPHGLPENVIKPAIAIA
                     RLNKPIVWDNKFMVDLVVLLALKENNKKEIRSLFSKINDQHTLEVLLNTEDKNEIKEL
                     LS"
     gene            66348..66806
                     /locus_tag="KR257_000746"
     CDS             66348..66806
                     /locus_tag="KR257_000746"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861526.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIA"
                     /protein_id="HBH0029473.1"
                     /translation="MEFINFVSDKVIDLKMDCKTKEDFFKEIHNKVFDLGFVKEEFGE
                     KILARENVFPTGLNLGDYGVAIPHTDAEYIKEQFISVCTFNEPVVFSSMEDQDEKVPV
                     NLAFVLGLNQPHSQLSVLTELMGIMQNKELVDKLMSSTDKEEVLKTLKSL"
     gene            66867..67142
                     /locus_tag="KR257_000747"
     CDS             66867..67142
                     /locus_tag="KR257_000747"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423118.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIB"
                     /protein_id="HBH0029474.1"
                     /translation="MKKILVACGAGIATSTVVCDKVERLVKENNIQAEVIQCKIAECA
                     TKQEGADLIVSTTILPTTYNIPAIKATAYITGVNTAALDKKILDALK"
     gene            67201..68475
                     /locus_tag="KR257_000748"
     CDS             67201..68475
                     /locus_tag="KR257_000748"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012951111.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS galactitol transporter subunit IIC"
                     /protein_id="HBH0029475.1"
                     /translation="MDKLLAVVQYILNMGPTVILPITIVVLGMIFRIKFTKALKSGLT
                     IGIGFVGINLVVNLLTSTLGPAAQGMVERFGLNLTVIDVGWPTTASATWASPVAPILI
                     PVCLLVNLLLLYFNKTKILNVDIWNYWHFIVAGAVGYIVTGSYVWAIFCAILMELLVL
                     FIAEKTAKNVQEFYDLEGIALPTGSTASFAPLGYLVGKFVEKIPGINKIQADPDSIQK
                     RFGIFGEPMMMGIILGIILGALAGYDVAGIFNVGISMGAVMLLMPRMVRILMEGLIPI
                     SESIRDFLQAKYGDRELYIGLDAAVATGHPAVISTALILVPITLFLAVILPGNKVLPF
                     GDLATIPFYMAFIVCFRKGNIVQSVITGTIVIAISLYMATNFADVHTQLLQQANMMPE
                     GTTMVTSIDTGGNLLKWGILKLSQLVSSFGIF"
     gene            68605..69657
                     /locus_tag="KR257_000749"
     CDS             68605..69657
                     /locus_tag="KR257_000749"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430708.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="galactitol-1-phosphate 5-dehydrogenase"
                     /protein_id="HBH0029476.1"
                     /translation="MKAAVLHGTNDMRFEDIEIKPCESDEVKIKVMAAGICGSDPPRV
                     LKHWKYPVPAIPGHEFSGVIAEVGKDVKNVKVGDRVVAIPFIPCNECEYCKRGLFSLC
                     DDHGMLGAKSFGAFAEYVNIKATNVLPIGDMNFEDAAMIEPLAVAMHGVLNIGVQVGD
                     TVAVMGSGTMGQLVIQGLKIAGAGTIIAVDISDNKLRESKELGADIIINAKDINPVEK
                     IKELTGGKGVDIALECAGSKITQEQCLLITKKKSKIGFLGIAYSDITLSEEAFENIFR
                     KELELKGFWNSYSAPFPGQEWTKGINLVNEGKIKLKEMVSHRFSLEDTYKAFEMIRDR
                     KEEFNKILILPQGVEK"
     gene            69657..70688
                     /locus_tag="KR257_000750"
     CDS             69657..70688
                     /locus_tag="KR257_000750"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012986518.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="zinc-binding dehydrogenase"
                     /protein_id="HBH0029477.1"
                     /translation="MKAVVKTKPGYDNVEVLEVEEPKATGDKVKIKVEYSGICGSDIH
                     SFKGEYANIKAPVTLGHEFSGIVVEVGEDVKNIKVGDRVTSETTFATCEKCIYCETKD
                     YNLCPTRKGIGTQVNGSFAEYVLSREESIHVLPENVSLLSAALTEPLACCVHAALEKT
                     TIESSDTVLIIGPGPIGLLLAQVVKSQGATVIMSGVTKDKERLEIAKNLGVDRTVNVM
                     EESLADVVNEMTDGNGVNKGFDCSGFMPAVNEALRLLRKKGTFVQVGIFAKKLNEMDQ
                     EAIIQRELQYIGSRSQKPSSWITALDLMANGKVNTEALVTRTVGLDEFKEGITALMNG
                     EEIKVAVKS"
     gene            70780..71592
                     /locus_tag="KR257_000751"
     CDS             70780..71592
                     /locus_tag="KR257_000751"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423126.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transketolase"
                     /protein_id="HBH0029478.1"
                     /translation="MSTLRDHSNNIRKNIIKMVAEAKSGHPGGSLSIADMLTVLYFDK
                     MNVCAENPKMADRDRFVLSKGHAAPALYATLAEKGFFPEEELITLRKFGSKLQGHPDM
                     KKVAGIDMSTGSLGQGLSAANGMALAGKLDNKDYTVYTILGDGEIQEGQIWEAAMTAS
                     HYKLDNLIAFVDLNGLQIDGSNEEVMNVSPVDDKFKSFGWNVIVINGHSFEEIGNAVD
                     EAKKVTGKPTVIIAKTVKGKGVSFMENNAAWHGTAPNAEQAEQALKDLEGGL"
     gene            71595..72515
                     /locus_tag="KR257_000752"
     CDS             71595..72515
                     /locus_tag="KR257_000752"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430702.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transketolase family protein"
                     /protein_id="HBH0029479.1"
                     /translation="MGIATREAYGQVLKELAENKDIVVLDADLGKATKSISFKEVAPD
                     RFFDMGIAEGDMIGTAAGLATCGKIPFASTFAIFAAGRGYEQIRNSVAYPNLNVKIAA
                     THAGVTVGEDGGSHQAIEDISLMRGIPNMVVLNPADALEARQAILTSIDYNGPVYIRL
                     GRAATPDVNSENYKFEIGKGTVLREGSDITVIATGIMVAKALEAAEELAKEGINVEVV
                     NISTIKPLDEALIKETAKKTGKVVTAEEHSIIGGLGSAVCEALAETKDVVVRRIGVKD
                     VFGQSGTPADLLKHYGLTTEDIVKNIKELL"
     gene            72690..73136
                     /gene="rpiB"
                     /locus_tag="KR257_000753"
     CDS             72690..73136
                     /gene="rpiB"
                     /locus_tag="KR257_000753"
                     /EC_number="5.3.1.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430700.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribose 5-phosphate isomerase B"
                     /protein_id="HBH0029480.1"
                     /translation="MKISIGCDHGGYELKEYIKENLINKGIEVEDVGTNSKESVDFPI
                     YAKKVSQNVQSKKSDLGILCCGTGIGMSIAANKFKGIRAAVVSDCFSAKATREHNNTN
                     VLCLGERVIGKGLAMRIVEEWLNSSYNGERHARRLQMIDDIEKENL"
     gene            73166..73831
                     /locus_tag="KR257_000754"
     CDS             73166..73831
                     /locus_tag="KR257_000754"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728811.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribulose-phosphate 3-epimerase"
                     /protein_id="HBH0029481.1"
                     /translation="MSIICASIMCADQMKLKEELEALEEAGVKLLHCDVMDGIFVKNL
                     AMGPELLKSISENTTIPLDIHLATETPDKYIDMMSYIKPKYISFHVESSTNVKADIQK
                     LRNYGIGPVLAISPQTSVDKIEEYISLVEGILVMTVNPGFAGQKFNLSVLDKLDKLTE
                     ILKDYDNPPFIEVDGNINKDTIKLMNGKKVDIYVVGTSALFNDKPPISYKDKIEELKE
                     SIK"
     gene            73941..75443
                     /locus_tag="KR257_000755"
     CDS             73941..75443
                     /locus_tag="KR257_000755"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890519.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphomannomutase/phosphoglucomutase"
                     /protein_id="HBH0029482.1"
                     /translation="MGDLYKLQNGTDIRGIAYENDSKEVNLTVEEVKKIAKAFHIWLK
                     EKTKKDKVTVAIGTDSRITGSQFRSTVIETLTNDDCNVIDCEIATTPAMFMTTIMDGY
                     NSDGAIMITASHLPYYYNGLKFFTESGGLEKTDIKEMLDIAVKNDSVDYEEVNKKGEV
                     IVKNLIEDYSNLLIDKIRKGVNSSKNYEKPFSGLKILVDAGNGAGGFFAEKVLHILGA
                     DTTGSQFLNPDGMFPNHIPNPENKEAMESICKAVLDNKSDLGIIFDTDVDRAAIVGKN
                     GKPINKNALIAVISSIVLEEHPKTAIVTDSITSEGLAKFINELQGRHHRFKRGYKNVI
                     NEAIRLNSEGEECHLAIETSGHAALKENYFLDDGAYLIAKILIKVAKLSLEGKTIEEL
                     IENLEEAQEEKEVRIGINKEDFRTYAEDILKDLDSHVKSIDGWSVAPNNFEGIRVNCD
                     ESNGDGWFLLRISLHEPLLALNIESNKIGGAEQIYSKLKLFLEKYDLKGL"
     gene            complement(75755..77344)
                     /locus_tag="KR257_000756"
     CDS             complement(75755..77344)
                     /locus_tag="KR257_000756"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897499.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sensor histidine kinase"
                     /protein_id="HBH0029483.1"
                     /translation="MVTKLKNLIINDSKAKFILLLLLFLLVSILFEAVYDLNNNFSNI
                     NYYYREFALPYFYFFGTPVHLSKVELEFVCIGIILSSFLLTILCFTLYKKNKQTKVKF
                     LENVINLFSKVKIELTLILTLILLTLRFHAFTSNKMFYNTNLIIYNFIIISIVYIIYE
                     NIKYNNYNLKDMSITYVFFSNLLSMYNKKTINKKLAIVFLISIVVQAIIQYLVLIFFM
                     YIYYAEAIAIVILFTLVNTVFHFYIYNFLSVKFNYINNISKNIKNIENGNLKYKLEVI
                     GDDEISTLAKSINNITGGLETAVDANIKNERMKAELITNVSHDLKTPLTSILSYVDML
                     KNNDFDRETINDYINILDKKSQRLKLLIDDIFEASKLSSGDVEFNITKTDIRELLIQS
                     IVEFEDKIQNSSLDFIIETPEYAVFTMIDGKKTWRVFENLICNILKYSMPNTRVYIDM
                     FIKEENIILTFKNISNDKLNLKPEELIERFRRGDISRKTDGSGLGLSIAQNIIELENA
                     HMEIIIDADLFKVMLTFRKVN"
     gene            complement(77313..78029)
                     /locus_tag="KR257_000757"
     CDS             complement(77313..78029)
                     /locus_tag="KR257_000757"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890517.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HBH0029484.1"
                     /translation="MNQNILVVDDDREIVDAIEFYLRPDNFNVLKAYDGLEALDILIE
                     NDIKLIIMDVMMPNLDGLKTTLKIREKRNIPIILLSAKSEDMDKIIGLNMGADDYITK
                     PFNPLELTARVKSQLRRYINLGDFSNTNNSNDTNYILKSGGLELNTDTKIVSLDGEEI
                     KMTPLEYKILTLLMSRKGKIFSSHEIYENVWNEDAYSCERTIAVHIRRIREKIEINPK
                     EPKYLKVVWGIGYKIEKLNY"
BASE COUNT        30732 a         8587 c        14153 g        24743 t
ORIGIN      
        1 ctgaagtata tctagaaaaa attaaaaatc atagcttaaa agaagtagag aagtttgatt
       61 tatttataag tttagccatg tattatgcaa aaagtaatga aaaatctttt gaacaatcaa
      121 tatgctattt agatagagct aaaaacatat taaatatgat aaaaaatata gaagaatata
      181 taatatatga tttagaaata atttatcacc aggcaaagat atattatatc tttggatatt
      241 atgataatgc cttaaacaca aataaaaaac tccttgaaaa atctaaaaat gctaaaaatt
      301 ataattatgt gaagttagca tacaagagta tatatttgtg ttttgaaaag attcaaaatt
      361 atgaaatgag tatgaaatac tttaaaatgt attatgagtt aaaaatgatg tatataaaag
      421 ctcgaaatag aaattatata gattccttaa attatagaca tgagtatata gaaaaagaaa
      481 taaataacat gagaaaagta aaacttgatt tagataaaaa aaagtatgtt gaccatttga
      541 caagtgcata taatagaact tttttgaacg attttttaga aaaacaagaa gttagtgaat
      601 attgcacagc atttatgata gatgtagatt actttaaaga atacaatgat acttatggac
      661 actataatgg agatattgct cttaaaaata taactataat aataaaaaaa tatctaaaaa
      721 aagacatgct tatgataagg tatggtggag aagaatttct gatattatct gtatgtaaag
      781 attataaaaa aagtaaaata tttggaagaa aattatgtag gattgtaaag aaatttttaa
      841 acaataattt gacagttagt attggcattg atacatgtaa aaatagtagt atagatataa
      901 aagaaataat tgaaaatgct gataaagctt tatataaagc aaaggaaagt ggtagaaata
      961 gatgtttgca ttatcatgat tttaagaatt tttaactgtt gaaataggat tggtgattta
     1021 cttgaaaagg agtttaatag aagatttaaa gagaaatata aacaagatag aatacgatat
     1081 gttgactaaa ttctatctaa atttgacaga tttaaactac atcttggatt atcacaaaga
     1141 ccttttaaat acaaaattag aagataatag tagagtctat actttatatt taattagtct
     1201 tataaactat ataaaaaaag atagagaagc atcatacaac tatttgatag agtcattaaa
     1261 gtatattaaa aaattgtcat taaaagatga ttcagatata atatctaaaa tttatattta
     1321 tcttacttta tcagctattt ctataagaaa atatgataag gtaaataatt tttatttctc
     1381 agcaaaaaaa attataagac aaaatcattt aaatgagttg ttggtattgt taaatatgag
     1441 tttatgtgta gaaataagtg ctttatatca gaccaaaacg gatgtaatag ctttagtaga
     1501 agaagtgtct ttttttaaaa ctttaaaaaa taaagctctt gtaagtaggg caaattatat
     1561 atttgggaga gtttatctat atttatttaa taactttata aaaagtatgg aatacttaat
     1621 tgaatgtcta aaattggctc aagaaaataa tttatactct atagaggctt tttgtaaatg
     1681 tataataagt ttgtgttatt tagagagtgg aaataatgta gaagctataa aatacataaa
     1741 taatgtatta gatgttgcac acagtaataa ctcaatatca gtaactgaaa gagtgtctat
     1801 aaaaatagac cttatatggg catatttaaa agaagatatg aataaagaag cagaagttat
     1861 tttattaaag actataaaat taatgaaagt tgttgaaggt gtatataagg attatttata
     1921 ttcatttata tttttatatt cagctgaaat tgagttaaag aaagataatt gtagttttga
     1981 aaaggtaaac acctatttaa ttttatcaaa aaatatatat aaaagttttg gagatgtttt
     2041 tatatataat tctaaactag attacatata taagttgtat ggagatttat atataaaatt
     2101 tggtaatata gatgaaggta taagttgtta tataaaaggt ttaaatttag ttaaaaagag
     2161 ttcattgaat cttagaaaaa tatctatatt ttatgggcta atagcaaatg gatatgagct
     2221 aaaaaaagat tttaaactgg caatagaata ttataaaagt atggattggt attctgatag
     2281 gtgggaaaaa aataattcct ataaaacatc tcaagcaatt cacaaacaat atgaactcag
     2341 acaaaaacaa gagagtttaa gattactagt ggatgataat aagaaattag aaaatgatat
     2401 tttaaaagat ggacttacta aactatataa tagaagatat ctggaacagc agttggattt
     2461 atttaatgaa accagagaca aaaatatggt cgcaatactg gtcgatatag attgttttaa
     2521 aagttataat gataattatg gtcatctagc aggagataaa gttatagtta aggtaactga
     2581 tattataaga agtgtattta tagatattac cgaacacata atcagatatg ggggagaaga
     2641 aattttaata ttagtagatt ctatagaatc aatcggtgtt gaagagattg ataatataga
     2701 attatatatt aaaagagttt tcaaacttct tgaatttgag ggtattgaac atatatattc
     2761 taaaataaaa aactatataa ctataagtgc tggagtaagt ataaaaagat gtcgtagtag
     2821 aaaagatgtt gaaatattaa ttgaagatgc agataagaac ctatataaat caaaaaaagc
     2881 aggtagaaat caatacatta taatttaaaa ttgaggtgat tttgttgcga aaaaaaatag
     2941 gaattatagc ctctgatatt gaattaaaag aaagaataga agaattatat agagaagatg
     3001 tagaaaatgg aactataata atcgacatac ttaacctaga cttaatggaa aatcaaggtc
     3061 gtatacttgt tgaaaaaggt gcccaagcta taattggtag aggtggaggt tatagtttag
     3121 taatagatac agtaaatgta cctgttatac caatgaatat gaagtcaact gaccttttaa
     3181 gagcaataga aatagcaaag aaatattcta aaaaagtagt attgattctt ggagacaatg
     3241 aagtttcttt tgactatgtt ggctggagaa atgtcataag tactgaaata actgaagaat
     3301 ggtttgaatc taagtatgag ataagaagta aagttgtaaa atatatagac caaaaagatg
     3361 aaattgtaat cgtaggagga ggtttggcat gttcttttgc aaggcaatat ggaattgata
     3421 gtgtatttgc aactgctagt gatgaatcta taagagaagc tgtagaatat tgtaaaaaat
     3481 tattagatac attaggtgaa gaaaagttta ataatgaagt gttacgaaat atacttgatg
     3541 gtataaaaga tggagtaatt gctatagata gtaatggcag tataattttg tacaatgaaa
     3601 gtgcaaaaaa catgcttaaa gtagagagaa aatgtgcact taataaatac atcttagatg
     3661 tatttcctaa aatggagtgg atgttagatt gtttacatga aaaagaggac gtagaagata
     3721 gaaagataag aaatataaat aatctaattg ttaatactag gacaacattg ataaaagttg
     3781 ataatagtac ttatggagtt ttaggaataa tacaagatat aaccaagcta caaaacttag
     3841 aaagaaaaat aagatttgac ttgaatcaaa aaggtctcta tgctagatat acttttgatg
     3901 attttttatt taaagataaa ttaactaaag aatttattga agaagctaaa aaaattggaa
     3961 aaagtgatta tacaacttta ctttatgggg aaagtgggtc tggtaaagaa attatagctc
     4021 atagtataca caatataagt aaaagaaaag ataggccttt tgttgctata aattgtgcta
     4081 ctatagcaga aaatttactt gaaagtgaac tttttggcta tgaagaaggt gcatttactg
     4141 gtgctagaaa gggtggaaaa agagggctat ttgaacttgc tcatggaggg actctttttt
     4201 tagatgaaat aaatagtcta tcctttaata ttcagacaaa actattaaga gtaatagagg
     4261 aacgtcaaat aatgagaatt ggttctgatt atataatacc tctggatata aggattatag
     4321 cagcaacgaa cgaatcttta accgaaaaaa tagttatggg tacatttaga gcagacttat
     4381 tttatagatt gagtagttta gagataaata tacctccttt aagagacaga agagaagata
     4441 taataccttt gtttaacaat tttgtaaatg aagtattaaa ggatgatggt ctcaatggaa
     4501 taaacagtat agatgaaaat tttgttttga ctaaagatga aatggataag ctatataatt
     4561 atagctggcc tggaaatgta agagagttaa agacaatagc tcaaaaatat gttgtgacag
     4621 gtaaaattaa attgagacaa gatagagatt ttaaaactaa aaaattactt cctaactctg
     4681 aagtagacaa atttaattct gaaacgacag caagtgtaga agtccaagat gaatctataa
     4741 atataagtaa gataaatgat ggtaagataa gtatagatat aaaagaagta aataagtatg
     4801 ttgaagaaaa aataataagt atgctttttg ctcaaggact ttctaaaaat gaagttgcac
     4861 aagttcttgg aataagcagg acatctttat ggaagaaata caataaaaat atttaaatat
     4921 aattacatat aaattatttt gaagtaatgt taatttttta aaacaagtgt taagaaaaat
     4981 taacattact tttttgcaaa tttttatttt tttagacagg catatatatt tataagaaaa
     5041 atagttaaaa cacttaattt aataatgaaa aaaataataa ttctaaacaa aatcaatttt
     5101 acataaagtg ggatttattg gcatagtaat tgcttaatat ataatgtaag agtaaataca
     5161 attttagggg tgatggtatg agtcaaagta tggttggtaa gcatgcaatg tggccaaaag
     5221 aaaatgatgt tatatttagc atatctggca gagctcaagc agcagagaag gcttttggta
     5281 tggataatgt aataaatgca acaataggcg ctctaatgga tgattcagga aaattgataa
     5341 caatgaaaac tgtatatgaa gaatataaag cattagataa ctgtgagata ggtgcatatg
     5401 cagctcttga aggtcaacca gattacttag aagcagttaa aaaagtattt ttcagagatt
     5461 acttaccaga aggacatata agagtattag cttcaccagg aggaagtggt gcaataaaat
     5521 tagctgtatg gaactatact aatgaaggag atgaggtatt aacatctgat tggttctgga
     5581 gtccatatgt aagtatagct gaagaggcta atagaaaagt agttaattac caactttttg
     5641 atgaaaatag aaggtttaat tttgagtcgt ttaaagaaaa atttgtaaat atagcagaaa
     5701 aacaaggtag agtctttaca attataaaca caccagcgca taatccaact ggatatagtg
     5761 ttgcagatga tgagtgggat aaaatattag acttatcaaa agaagtcgca aaagataaag
     5821 acaaaaagat aatatttttc gtagattcag catatattga ctttgcaggt gatgatgatg
     5881 tatgtagaaa gttttttaag aaattttcta atttgcctga aaacgttctc gtattggttg
     5941 gattcagtat gtcaaaagga tttacagctt atggtatgag aatgggggct ataatttgta
     6001 tatcttcaag tgaagatgta gctgaagagt tccattactc atgtgttcat tcatgtagag
     6061 caaattggtc aaattgtaat agaagtgcca tggcagtatt atctaacatt gtaaatgacc
     6121 ctaaaaaatt caaagaatat gaggatgaaa aagaaatata caaaaacatg cttactagaa
     6181 gagcagatgt atttgtaaaa gaagctgaaa gagtaggatt agaaattctt ccatatatag
     6241 caggtttctt tgtaagtata ccatgtgata atccaaaaga agtatgtgaa gaattgacta
     6301 aacataattt atttgcagtt ccattaaaaa tgggtttaag atttgcagtt tgtgcagttt
     6361 ctgaagataa atgtaagaaa gcaccaagta ttataaaaga agcacttgaa agtttagaag
     6421 taaaaataaa taattaattt cattgaacaa attgggtgga ctatgaattt aataattgta
     6481 gatggaggga attttatatg aaacaattga tgacaggtaa tgaagcaatt gcacgtggag
     6541 cctatgaggc tggtgttaaa tatgcatctg catatccagg gactccaagt acagaaatat
     6601 tagaaaatat agcaacatat aaagatgcaa tagttgcaga gtgggctcca aacgaaaagg
     6661 tagcacttga ggctgctata gggggttcaa ttgcaggagc aagaacaatg gcttctatga
     6721 aacatgttgg tttgaatgtt gcagctgatc caatatttac ttatgcatat acaggggtaa
     6781 atggtggtat ggtacttatt acagcagatg agccgggaat gcattcatct caaaatgagc
     6841 aagacaatag gatgtatgca aaatttgcaa agataccttt atttgagcca tcaactagtc
     6901 aagaagctaa agatatgata aaagaagctt ttgaagttag tgaaaaatac gatacaccag
     6961 ttttatatag agttacaaca agactttgtc attcaaaagg attagtggag tgctatgata
     7021 gagaagaagt tgaaattaaa gagtatgtta aaaatgctaa gaaaatggta actgttccag
     7081 caaatgctca aataagaagg ggcgttgttg aagaaagaat ggaaattctt aaaaaattct
     7141 caaatgaaac tgatttaaac tactatgaaa taaatgatac aaaaataggt gttatagcct
     7201 ctggtatgtg ctgtaatttt gccaaagaag tttttggaaa aaatgcatca tatatgaaac
     7261 taggatttac aaatccatta ccttatgaaa aaataaaaga atttgcagaa aaagttgata
     7321 aaatatatgt tatagaagaa aatgacccat ttatagaaga acaaataaaa gcatatggaa
     7381 tagattgtat tggaaaagat gtaataccac catatggaga aatgacacca gatgttttaa
     7441 gaaaagctat atttggaaaa acaaatgata ctatagaata caaatctgaa ttagtaacac
     7501 caagaccacc aagtttctgt gcaggatgtc cacatagagg attcttctat gaacttggaa
     7561 agagaaaaaa tttaatagtt ggtggagata taggttgtta tactcttgga tttgctcctc
     7621 catataatgg aatagattat gttgtttgta tgggttctgc ttttggaact gcacatggag
     7681 ctcaaaaagt tcttaatatg aaggatgata atgaaaaaag attggtaggt gtacttggag
     7741 actcaacatt cttccataca ggaataaatg gacttttaga tgttgtttac aatagaggta
     7801 attctatttc ggttatatta gataatagaa taactggaat gacaggtcac caagaaaacc
     7861 caggttcagg atatacttta caaggtgcta aaactaaaga agttgatata gaaggattag
     7921 ttaaagcttg tggaatagaa catgtaagag ttataaaccc taataattta aaagaagtaa
     7981 atgaagcact agattgggct ttagctatag aagatgaacc atcagtaata ataacaagat
     8041 ggccatgtgt acttaaaaaa ttctctaaag aagatataga agaatttaat aatccattta
     8101 agactaagtg taaagttgac catgataaat gtataggatg taaattatgt ttgaaaactg
     8161 gatgtccagc tctatcattt gataaagaga ataagttatc aaatatagat agaaatcagt
     8221 gtgtaggatg tggagtatgt gcacaagttt gtccaaaaca agcaatagtt aaggaggaaa
     8281 aataatatga ctaagagtat acttttggta ggtgtaggag gtcaaggaac tatacttgct
     8341 agtaaattat taactatggg attgatggaa gctggatatg atgtaaagat gagtgaaata
     8401 catggaatga gtcaaagagg aggttcagtt tcctcacaag ttagatatgg agattgtgtt
     8461 cattctccag ttatagaaat tggtggagca gatatattag tatcttttga aaaaatggaa
     8521 gctttaagat ggttcaatta tttaaaacca gaaggaaaag ctttagtaaa taatcatagg
     8581 atagattcta tgactgtttt aatcggagga gctgaatatc aagaaagtga tatagatgca
     8641 gagttaagta gattaaatgc aaaagttata aatgcagctg ataaagctga agaactagga
     8701 aattcaaaaa taatgaatgt tattttatta ggatgtctag ttaaatctat gcaattagag
     8761 tctattgatt gggaaaaaat tataagtgaa aatgttaaac caaaatttgt tgaattaaac
     8821 ataaaagctt tccatgaagg tatggaaatg gttagcaaat agtttataat agatataaat
     8881 agactataga aattaaggtg aaaggaagaa aattatgact tacagaatat tagccataaa
     8941 tccaggttct acttctacaa aaatagcagt atatgatgga gaagaacaaa ttcttgtgaa
     9001 gacgatagac catccagctg aagagattgc aaaatataat actatacaag accagtttga
     9061 aatgcgtaag gaagcagttt tgaatattct taaagaaaat agtatagact taaaatctct
     9121 tagtgcaata gtaggaagag gtggagtttt accaccagta aaatcaggag catatttagt
     9181 aaatgaagaa atgattgatg tactaagaca tagaccagta cttgaacacg cttccaattt
     9241 aggtgctgtt gtggcacatg caatatcaga acctcttgga atcaactcat atatttatga
     9301 ttctgttgca gtagatgagc ttatagatgt agcgagaata tctggacttt gtggaatgga
     9361 tagatcaagt gcagggcatg cattaaatac tagagcaatg gctttaaaat atgctaagga
     9421 taaaggaaaa gattataaga gcttaaactt aatagtagct cacattggtg gaggagtaag
     9481 tatttatctt catgaaaaag gaagaatggt tgatatgcta tctgatgatg aaggaccatt
     9541 ttctccagaa aggtcaggaa gagtacctgc tacaaaatta gtggctgcct gttattcagg
     9601 tcaatattca gaaagagaaa tgactaaaaa gataagaggt aaaggtggta tagtttcata
     9661 cctaaatact gtagatgcta gagaagttga aaaaatgata gcagaaggaa atgaagaagc
     9721 aaaaattatt tatgaagcaa tggcttatca gttagcaaaa ggtattggag agttagcaac
     9781 tgtagtagat ggaaaggtag atgctataat tataacaggt ggaattgcat attctgaaat
     9841 gtttacttca atggttaaaa agaaagttga gtttatagca ccagtagaaa ttatggcagg
     9901 agaaaatgag ttggaatcac ttgcttttgg aactttaaga gtactaaatg gagaagaaga
     9961 agctagaatt tatagtgaaa attaataaga aaaactaaaa atgtttatat actaaaaaag
    10021 tggtatatcc gttttttata cacgaaagct tagagtatag gtgaaaatgt ataaaatttg
    10081 gattgccact ttttataatt aaaattttat cttaacctaa taaataattc tgtaaaattt
    10141 cgtatttata tatatatttt attggtattt attgttatta ttattatgag gagtgatttt
    10201 tgatgggaaa aataagttta aaaagtatga taagattatt ttcaggtttt tttatatttg
    10261 caatttcttc tgtgcttatg attaatgcac atgtaggtct tatgccttgg gatgtacttc
    10321 accaaggttt atctataaag ctaggcataa ctataggtca ggcttctata atggtaggag
    10381 ttgtaattgt tatattggat gcagtttttg gtgaaaatat aggatggggt actttactca
    10441 acatgacatt tataggaatt tttattgatt tagtaatatt ttctggagtg atacctcatg
    10501 caagcaacac ttatataggt gtgtttatgg ttgttatagg aattattttg gcagctatag
    10561 caagttttct atacttaggt gtttgtttag gaagtggacc gagagatggg cttatgattg
    10621 ctcttcagaa aaaaactaat aaatctgtac gtcttgttag aacaattctt gaaatactag
    10681 cattagttgt tggatggtta ttaggaggtt ctgtaggtat tggtacgctt gtaagtgctt
    10741 taggtttagg atatgtatta caaatagtgt ttagaatatt taaatttgac acaaaattgc
    10801 tgaaacatag atttattata gatgatataa gagaatggaa ggaaaagaaa agcaatgaac
    10861 ataaatgtaa atcaagtatt gtaataaaaa atgagcagaa ttaattatgc taaaatatat
    10921 ttgtagttta tctaatttat agtaaagtca aggagatttt gaaatggaat tatgggattt
    10981 atataatgct gatggaatta aaacaggaaa tgttataaaa agaggtaatt ctattgaaga
    11041 aggttattac catttggcag ttgaagtgtg gattttaaat agtaactctc aaattttaat
    11101 tcagaaaagg tctaaaagta aaaaaacatt gccaaatatg tggggaatga caactggatg
    11161 tattgtttct ggggaagaca gtttagaagg agcaattcgc gaagcaaagg aagaaatagg
    11221 gatagatata actaaagatg agatgaaagt ttttagaagt atgattcatg aagatactct
    11281 ttgggatgta tacttagtta aaaaagaata tgatatatct aaagctattt tacaggagga
    11341 agaagtaagt gatataaagt gggtaagcac agatgaaata agacaattac taaaagaggg
    11401 tttgtttttt gaatatccag agatatacga attgctatat gagatagata ataataaatt
    11461 aaatatatga tgtagagcag atttcagtat aagtaagatt atttaaaatg tatcttctct
    11521 aaattttaat attgttttat gaaaattaat aagttatttt tagtattttt ctacttgttt
    11581 tttgagatta aaataaaaag ggcagtcatt ataaagtcat aaaaatttgg ggaggattta
    11641 aactatggaa gataacaaag gattggcacg tgacagttca aaatataaaa ttgtttctat
    11701 atctgtcgta gtaattattc taattacatt ttggtatatg ttaaatatgg tgcttttaac
    11761 atttattatg acttttattt tctataactt gcttgtagcc acaagaaaac gaattaagaa
    11821 gttttcttct ttaaatattc cagattcatt gataattata gtgttatatg cactatttgc
    11881 tatattgtta gtattgatta gctatgcagt tgtaccaata attatagttc aacttacaga
    11941 gttgagtagg gtttttagtg attttgatgt aaatcaattt gctcaatctt taggaccgaa
    12001 attgtatcct attgtctcaa agctggattt taataaatat atttcacaag cagggctact
    12061 tatagcatca acagcaacaa aagttggaag ttttggagta aatatattat tggcattttt
    12121 actgagttta ctccttttac ttgaaaaaaa tgaaattaaa aattttggag ataaactttc
    12181 tgatagtaag atttctttta tttataattc gcttgtattt tttggaaaga gctttgttaa
    12241 aaattttggt gaagtaatga aagtacaagt tatgattgcc tttataaatt ctgttgtttc
    12301 tatgattttc ttaggtttca tgggattccc tcaaatatgg gctttaggat ttatgatttt
    12361 tgtgttgggt cttattccag tagcaggagt tatagtgtct ttgattccat taactgtaat
    12421 agcatttaat acaggaggaa taacaaaggt ttttggagtt ttacttatga tttgtatagt
    12481 gcatgcagta gaaacataca tattaaaccc taagttgatg tcgaatagaa ctaaacttcc
    12541 agtttgtttt gtttttatta ttttacttgt aggagagcat tatttaggtg tatggggatt
    12601 actaattgga gttccaatat ttatgttcct tatggatatt ctgggtgtta aatttacttc
    12661 taggtaatat attaaaataa taatttattt ttatatataa attatgaatt gttttaaaaa
    12721 agaacctata aatagacatc attaataaag acatctattt gataggttca attttgcttt
    12781 gtataaatac tataaaacta aataaaaaga aatttatttc atttcaaaag tttcacaact
    12841 tgcatttctt tcatttatat gaactttttc agctttgcaa agttcatttt tattgtattt
    12901 acattttaca gcttcacaat gaatgttatc tgtatcaact tggttagttt cattagaacg
    12961 actagttata ccagatgtat atttgtcttc aaaagaagca caataagtat tttctgtagt
    13021 agttgcttgc attccatcta cttttatact accagcataa caatatccac tagtattata
    13081 agcacaatta gtagcagcac aatttaaatt attatttttc ataaataacc tcctaagttt
    13141 tatttaaact tattatgtga agttatctaa attttataca cttatttaca attacattta
    13201 tcacatttaa caactacatc tttggaagtt tcccttccta aatttttatt aacatgatac
    13261 acatcaacat tttcagttga tccacatata gaacatttaa aattgttttc tagtagggtt
    13321 ctttctttaa ataacttcca atacatagaa ttgatgtaat cattataatt taccttgagg
    13381 catgtctcaa gaaagtttat gtatagattg tctaaatctc ctgtatttaa ttctgtatat
    13441 tctggttcaa aatattcaca acatcctcta aaatcgggct ttgtatctga aataacacat
    13501 ctaatatcat atctatagtc taggctaggc cccttaaatg aaagatgtgt gcaaaaagaa
    13561 caagatattt ctggtagatt tttttcaagt tcatgtaatt tattattcat aagtattcct
    13621 ccaaaaaatt tattttaagt atataaatga atagattatt ttaaaacttt tatttattta
    13681 tattagagat ttaggataaa tattccaata aggagtaaat acttaagtat ttattactgt
    13741 attaaataaa aaagaggcaa atctaacttg agattgccta cttttttatc attttttaat
    13801 aaaatttatt ctaagtatta ttttatttag atttagtcag ccaacttagt atctgctttg
    13861 ctttttaact ttctaccaga gcgtacagtt aaaatagcat ataatacagt aaatatggca
    13921 gctaaaacat atgatatatt tatgtttaag ttaaatccaa tttgagcatt aaatatataa
    13981 ctgaatataa caaaggaata aaacatacca ggaattaagc ttataatata attcttttct
    14041 tttattataa ggtaaactgt aatcattgca aatgcaaata tggcaatagt ttgattactc
    14101 caagagaagt atctccacaa tatattaaat ccagaagcac taagctttgc aaatataagg
    14161 atggctatga caggaataaa tatacagatt gacaatataa cacgatgttt cttttccttt
    14221 tggtcataat gaaagtaatc tgcaagcatt aatcttaaag atcttaaagc tgtatctcca
    14281 gaagttattg gtaaaacaat tacacctatt atagctatga taccaccaat agaaccaagt
    14341 aaatctcttg caaccaaacc tattacatca ggagaaccta ctaattcttt aggtattcct
    14401 ttattgtaaa tacccatagc agctgcagcc caaatcattg caattaaacc ttctaaaatc
    14461 atcatattat aaaaagtagt ttttccttct ttttcatttg aaactgatct tgctataaga
    14521 gtagcttgag ttgagtggaa tccagaaaca ataccacaag caactgtaac aaagaatgta
    14581 ggaataagag gaataccatc aggatgaata cctttccaat ttgcaagact taaattagct
    14641 aaatcataac cttgtgtaaa gattccaatt ccaacaccag cagcagataa aagtagaata
    14701 gctccaaata ttggatatac ctttcctatg attttatcaa ttggaaatag tgttgcacac
    14761 aagtaatata gaaagataag tccataaact atccagacaa ctggattatt tatagtcgat
    14821 ttcatattta aaatttgagt aacaactaaa tccccaggtg tataaataaa aactgcacca
    14881 actaaaagca ttaaaagaca aaggaatata ttatagactt gaaatacttt attacctaaa
    14941 aatctactga taagagaagg catttgtgct cctttttctc ttatactaat cattccactc
    15001 atatagtcat gcaaagctcc tccaaataca cagccgatag gtattagtat gaatgctatt
    15061 ggaccaaaca atataccttg gataggtcct agaattggtc ctgtaccagc tatattaagc
    15121 aactcaatta gactattttt ccattttttc attgggacat agtctactcc atcactttga
    15181 gcaagtgcag gtgtttttct gtcatctggg ccaaatactt tttcacaata agcaccatat
    15241 aaagcacctc ctattagtaa tatagccaag ccgattaaga atgttgtcat aatatcaccc
    15301 catttataaa attttttggt ctttgtatac atattatcta aatgtgtaga tttatattga
    15361 atttaattct ggacaaccta caaattctat aaagtattac aactaatata atttcagaaa
    15421 taaatacata tacataacca tgtacttagt atacaggtat ttggtaatat tttcaatgtt
    15481 atagcaataa agaatataaa caaaattctg ataatatttt acaaaaaaat taaaaaatat
    15541 aaaaattagt ttaaatagat ggagaaaaaa ggaaaatcaa ttgagaatat aaatgtctat
    15601 atcttaacaa tattaagagg tttaaaattc ttgaagaaag aatagtcaag tgatataatg
    15661 ggtttacagg tgtatataca ctagtacata tagaaagcgg tgcaattatg gataaagatt
    15721 taacatatca aatcaaagag ctaaagaaag aaaaaaatgc aataatactt gcccattttt
    15781 atcaaccacc agaaatacaa gaattagcag atgcagttgg tgactcatat tatttaagtg
    15841 agattgctag agattgtaaa gaagaagtgg ttgtattttg tggagtaagg tttatgggag
    15901 aaagtgctaa gatattatca cctgaaaaaa ctgtattgat gccagtaagt aacgctgggt
    15961 gtgctatggc agatatggta gatgaagaag gcgtgataaa attaaagcaa cagtatccaa
    16021 atgctttggt tgtatgttat ataaactcta cagctaaagt taaggcacat tgtgatgttt
    16081 ctgttacatc ttctagtgca attaaaatac tagaaaacat agataataaa gaaattatat
    16141 tccttccaga taaaaattta ggaggatata ttgcagaaca atttccagat aaaaacttta
    16201 tattttggga cggatattgt aaataccata acaatataag agctgaagaa ataattgagt
    16261 taaaagataa gtataaaaat gcagaagtat tagtacatcc agaatgtaaa aaagaaataa
    16321 gagatttagg agattatgta ggtagtacat caggaataat aaaatatgct actaatagta
    16381 aaaacaaaga ctttataata gcaactgaag aaggtatatt acatgaatta aagaaaaata
    16441 atcctaataa aaacttttat attcctggtg gaaaaatact atgtacagat atgaaaaaga
    16501 caacattaga aaatttatat agtacactta aaaatatgga aaatgaagtt attgtagaag
    16561 atgaaatcat ggaaaaggct ttaaattcac tgcttaacat gcacaaatta gcagaaggat
    16621 agagggatag acttatgaat ttagaacaag atgttttaat agttggaagt ggagtttcag
    16681 gattatactg tgcattaaat ttagataaaa gtttaaatgt gctagtagta tcgaaatcaa
    16741 caattgaaaa caacaataca tatcttgcac aaggtggaat ttcaactgct agaaatattg
    16801 atgatataga atcctttgta gaagatacaa tgaaggctgg gcagtataaa aatagagttg
    16861 aagcagttca agtacttgca gatgaatcta tagaaaatgt aggtcagata gtagaatatg
    16921 gtatgccttt agacaaagaa aatggagaga tagattacac aagagaagga gcacatagtg
    16981 taaatcgaat agttcatagt aaggataata ctggagaagt tgtttttaaa actttattaa
    17041 aagaagctaa aactagagaa aatataactc ttatagaaga tgcatatctt ttagatatat
    17101 taaaagatgg caataaatgt ataggagcta gaatttttaa atctaaaaaa gagattcatg
    17161 ttttttcaaa aatagtagtt ttagctacag gtggaattgg tgggcttttt aaaaattcta
    17221 ctaatcaaag acatcttaca ggtgatggaa ttgcaatagc tttaagaaat aatataaaaa
    17281 tagaaaattt agaatatatt caaatacatc ctacagcctt ttatgaagaa aataatgaag
    17341 gtaggagaat gcttatatct gaatcattaa gaggagaggg agctaaactt ttaaataaaa
    17401 ataaagaaag atttgtggat gaacttcttc ctagagatgt agtttcaaaa gctatttttg
    17461 agcaaatgga aaaagataaa ttaccttatg tgtatttaga tgcaacacat ttagatagtg
    17521 aatatttaat taatagattt tcttttattt ataatgaatg tttagctaga ggaacagaca
    17581 taacgaaaga atgtataaag gtatctcctg cacaacatta ttttatgggc gggatacatg
    17641 tagatttgga ttcaaaaaca tctatggaaa atttatatgc agttggtgaa attagttgta
    17701 caggtgttca tggagccaat agattggcaa gtaattcatt acttgaaggg cttgtatttt
    17761 caaaaagagc agctaaaaat ataaactcag ttatagataa tgtaaaagtt aagtttatag
    17821 atgtaccaga tatggatata gatatagaac aggtaaaaaa agaaaataaa atattagtca
    17881 taaaagaaat tgaaagaaca agtgaggatt ttggcgatga attatttgat tattgataga
    17941 atgatacagg atgctttgat agaagatgtt ccaagtgaag atataacaac taattctatt
    18001 gtggatgaaa attctaaatc tactgtagat ttaatttgca aacaagatgg tataatagct
    18061 ggcttaggtg tatttaagag agtttttgag atacttggtg atgtagatgt aaaattatat
    18121 aaaaatgatg gtgatagagt aaagaatcgt gaaaagatag ctgtattaac aggtagtact
    18181 agaaacttac ttgtaggaga gcgtgtagca ttgaattatt tacagagaat gagtggtata
    18241 gctactatta caagtaggta tgttgaaaag cttgaaggta caaatacaaa attattagat
    18301 agtagaaaaa cgatacctaa tcttagaata ttagataagt attctgtcaa agtaggtgga
    18361 ggatgcaatc atagatttaa tttatctgat ggaatattgc ttaaagacaa ccatattggg
    18421 gctgctggta gtgttaagaa ggcagttgaa ttagctagaa aaaatacttc ttttgttaga
    18481 aagatagaag tggaagtgga aactttagac atggtaaaag aagcaataga agccaatgca
    18541 gatataataa tgttggataa tatgagtttg gaaatggcaa aacaagcagt agatattata
    18601 aatggaagag ccattgtaga attttccgga aatgtaaatt tagatactat agaagatata
    18661 ggaaaaattg gtgtggatgt tgtttctgta ggagcgctta cacattctgt taaagctctc
    18721 gatataagta tgaagaattt gagaaatata taaattttat attgaaataa acttaattaa
    18781 aatagactcc ttaaatttgt tttataaatt taaggagtct attttttatt cattaaaatt
    18841 aataaaaata gaaaaaaatc aatcaataat ttaataaaaa tagataaata ctatatacac
    18901 ttttaataat atagttaata tctattttac agataaataa gaataaactt ataatataat
    18961 tgtatctgta aaattttgta aaatataaaa agtatagggg gaataaaaat gaaagtagct
    19021 tatattttta gtagtactaa tacacataaa attctagaca aaatgataat accacaactt
    19081 gaacaaggaa ctcatggagt agacgttcta gggatgtttt tctttatgga taatacctta
    19141 tttttatcta aaggtaatcc tgtaggcgag agactaagta aattacatga aaaaactgat
    19201 atgataataa tggcttgtga ccaatgtgct atagaaagag gtatagagaa taatttggtt
    19261 gatggagcta caattggatg tttcccaaac ctatatgctt gtttaggcag tgcaggtgtg
    19321 gaccaagtta taacgttata aattagtata ggatacaatc catagaaaaa tttattttct
    19381 gtggattatt ttaagtaaaa gataaattgt ttaaagtagg ggatgaacaa atgtctaaaa
    19441 ttttagttga atttataaac acttgaccat cttgtgatga acatggagtg tttataaaaa
    19501 aaatgtcaga aaagtatgct gataaattgg aaataaaatt atatcaagca gggaaagatt
    19561 tttcgtatat aaaaaaatat gggattataa caaaaggaac tttaataata aatcagaaaa
    19621 agaaatatga tagattaaat aaagatacaa ttgaaagggc aatagtagaa gctataaaca
    19681 ataattaaaa gtttaaaaat taggagtatc aaaaatgaat atattagaaa ttgttttaaa
    19741 tggagttaaa gatactatag tagcttctat agttacactg aatggagcat caggatggct
    19801 tatgataagt tttatcttgg caggtgtact tcacaatgtt ttaactccaa gaaggtttca
    19861 aaaacaactt ggaaataaga aattttcttc tttaattaaa agtactatct caggaatgtt
    19921 tttaccaata tgtagttgtg gagtaatacc acttggaata agtatgtatt attcaggagc
    19981 atatttagga ccagtacttg cttttatgac atcaactcca ataataaatc caatagctgt
    20041 agttctttgt ctaggtcttt taggtcctaa agttacaatc atttatctaa tagctggttt
    20101 tttagtacca tttttagtag gatttttagg aaattgtttt ggaaaagaag aattatcact
    20161 tcataatgat tcagaggaag aagtaataga attagaagaa gaaaaaagaa gttttatgga
    20221 aaatatgatt gatggtctta aatggtcttt tggtgaatta gcccttacta ttagtaaata
    20281 tgtagtaatg ggtatggttt ttgcaggatt tataacaact atttttccaa atagtataat
    20341 tcaaaaatat ttaggaaatc caggtttgct atctcttgga agtatagcaa tacttgcatg
    20401 tgttatgtat gtatgtgctg taggacatat accgtttata gcagcccttg ttgcaagtgg
    20461 agcatctcct ggtatagcga taacatttct aatagctgga gcagctacaa atctaccaga
    20521 acttataagt atgtttaaac ttattggaaa aagaactgtt attatatatt ctgtaacttt
    20581 gacactgtct tcaataataa ttggatatat aacaaattta cttttagtga ataataactc
    20641 agtaaattta gatgcaacaa attcttcaat acagttggca aataaactaa tgttaaatat
    20701 acctgatagt tttgagtatg tatgtactat tttaattatt ttatttgcat ttaaatcaat
    20761 aataccaaag atgaaagagg tcataggaaa tcatgcttaa aaagatagtt ataatatcct
    20821 gcatagtagt tgtgttaatc attttatcaa aaatagttga tgataacatc aaagaagatg
    20881 cttctattcc aaatgtgaat aaagaaacat tagaatattt tagaaaaaat tataaagaag
    20941 acataataac ttgtgctgaa gaagacttaa ataatgatgg gaaaaaagat ttagtagtta
    21001 tatataaaaa aagcaataat tcaaatgaaa tggtagtcgt agtttctgat aaaaatagcc
    21061 actatataac aaagccaata ccagcaccta tagagaatca aactataacc tttaaaaata
    21121 ttgatgataa agcaccaata gaagtaattg tatcagggtc taaaaatggt aatgtaggat
    21181 atgctattta cagagtagag ggtaaaaaat ttgttgattt atttggcgaa gatatggaca
    21241 aatgttgcta aaaataaaaa taatacataa aggtgggaaa tttatatgaa attatctaag
    21301 aagattcaag cattaatctt atttggtgta atgggtacat ctatattaac aggatgtagt
    21361 agtaaaccaa aagaaaaaga agaagcaaaa actggaaaag atgattatac aataacagta
    21421 ggttattata attgtgacca tatgactgcg ggaccagtag cagaatcggc aggaatatat
    21481 aaagatttag gtcttaatgt aaaaactgtt ggaaatggta aagttcctga agctatggca
    21541 gcaggaaaaa tggatgcagg ttacatagga actaaggggt tagttggagc aatacctaag
    21601 ggttcaccaa taacaatagc agctaacaac catactggtg gttctgaata tttaatagtt
    21661 tcaaaagata taaaagaacc taaagattta ataggtaaaa aaattgcaac agatatgagt
    21721 gatttcttat ggacaagtga ttatggtcca gaaacaggtc taccaactga cccatcaaaa
    21781 tatgaagttg taaatatgga ttcagacaaa gataaatatt tagctcttaa aactgggaaa
    21841 attcaagctt ttacatcttg tgacccttgg ggttctgtag ctgaaaatga cggtgcagga
    21901 aaaataatag catctactca atataaagaa aaagctaatg gcaaagaata taactgttgt
    21961 tcattctcat taaacaaaaa ctttataaaa gaacatccag atttagcaaa aaaattggtt
    22021 ctagcacata caaaagcaat agaatatata tatacaaatc cagctgaagc agctaaaata
    22081 tttgcaaaat attataatgt agaagaagaa gttgcactta gaactatcta taagaagact
    22141 gttggagaag gtagaactct tacttggaaa gttacaggtg aagaatataa aaataattta
    22201 caaatgtata aagatttaaa ggctttagat gatataccta aatatgaaga tacgattgat
    22261 acaagcttat tggactcttg tggagctgat gattttgaca aatttataaa agaaaaagtt
    22321 aacccagagt ttcctgaagg tatgagttat gaagactgga aagcaaaggt attataaata
    22381 aatggagaat atgaaaaata taataatact ttttatcatt attttgggaa gtatatttat
    22441 aatatttttt aattttgaag ataaagaaga aataaaagga aaattaagaa taggggtatc
    22501 tgatgatacc tctggttttg taataaatta tatggtaaat agagactact ttgaaaatat
    22561 aaaagtaagt gatataatgg atatttttac aattaatgat tgctgagcaa gtacaatgca
    22621 gtgggctctg agttcagagg aaatagatat agcaatcata tgtaaagatg ctgcaaaaca
    22681 atatgtaaat gtaaatagtg gatttgaaat tgttggtact gtagttcaaa attctgatat
    22741 atttctatta agtgataata atcctgaaaa gataggagtc attcaaaata gagattacca
    22801 gtcagaattg gttaaaaaat actacaagaa tgtggaagta gctcccttat tagggactgc
    22861 actagcatat ggattagaaa gtaatttagt agatggtgtt gtaatagatt gcataaagtc
    22921 aattgggtta gagggcaaaa gaaaatctac aactaaatta ggagattatg atacctatgt
    22981 attagttgta agtaaagagt ttaaaaaaag taaagcatat agtgatttta taacacttta
    23041 caataaaagt gttgatgctt taaagaataa agctacattt aagaaagcat taaaagagta
    23101 caggaatata agaaatatag atatggagga aataagcaat tggaaattaa aatttctaaa
    23161 gataaaagcg atagattaac taagaaaaaa actgatggta gtatggatat tttatataaa
    23221 ataatactat tagttattat atttttagtc tggcattttg cagcaaaaga tatagggagt
    23281 tctttgttac ttccaatgcc agtagatgta ataaaaggtt tctttttctg tgtgacagat
    23341 gcagagacag tcactaatct ttttataaca ttgcagagag tacttaaagg ttttatgtat
    23401 gcattattgt ttgggcttcc aataggattt attatgggat tttctaaaac ttttgaaagg
    23461 gttttatctc cagtagtaga ttctgtaagg caagttccaa taatggcatg ggttcctctt
    23521 actatagtat ggtttggtat aggagatggt ccaacaatat ttttaatagc tttttcaggg
    23581 gttttcccta taattttaaa tactattcaa ggagtaagag caatatcaaa ggattattat
    23641 aatgcagcta gaagtatggg agcatcgcca attgtgatat ttacaaatgt aattgttccc
    23701 gcatctcttc cagatatact aactggttca aggattgcta taagtacagg atggatgtct
    23761 gttatctgag ccgagtttat agctacgagt gccggtctcg gttactcaat ggtacaagct
    23821 caaacattaa tgcatacaga tgtattaatt gggcttatga tatttgcagc tttaatagga
    23881 tttataatag atagggtatt aaagtttata aataaaatcc tttgtagatg gaggtttgca
    23941 gattaatgaa gttaagtgta agagatataa ataagacatt tgtaaataat agagtacata
    24001 caaaggtttt agaagatata agtatggata tagatgatgg acaatttgtc tgtcttttag
    24061 gaccatcagg ttgtggaaaa acaactttac ttactataat aggtgggttt caaaaatcag
    24121 aacgtggaga tgtttttata aatgataaaa gagttaaaaa accgggcata gatagagctt
    24181 ttatatttca aaattatgct ttatttcctt ggaaaactat aagaggtaat gttctatttc
    24241 ctatgaaaca gcagaaaata ccaaaagaaa aaagagaaga aatgctagaa gaacttttgg
    24301 ttatgtcaga cttgaaagga aaagaaaaac tgtttccgca tcaattatct ggaggaatga
    24361 aacaaagagt ggccatgata agagctttag catgtaatcc agaggtatta ctaatggatg
    24421 aaccattagg agctgtagat tttcaaatga gacaaaattt acaggaagag ctagaacgaa
    24481 tatggataaa gaagaaaata actgcattaa tggtaactca tgatgttgat gaagctgtat
    24541 atatgagtga tagagttata gtaatgtcga gagataaagg aagaattatt gatgatataa
    24601 atatagatat tccaagacct agaattagag gaagccaaaa atatgaagag tacaaaaaca
    24661 aattaactga tactttatca aagtgttatg aagtttaaag aggagtagac atgagtcaaa
    24721 tagaaaaata caatagtttg gataatacac aacagaaaat aagaatctct attatggata
    24781 tgataataga taaaggttct agtgttacac ttcaagaagt gactgaatat ataagtaaaa
    24841 agttgaatat agaaaaagaa tatatagaaa ggacactaca atattttatt tataaaaata
    24901 taatggttgt tgatgggaat agtataaatt ttatatatcc tgtatcagca ttgccaacaa
    24961 atcataaagt aactttgaga gataatagaa gtttcagtgc aatgtgtgct atagatgcta
    25021 taggaacctc ttgcacattc aaccaagata taaaaataaa ctctatttgt agtgctacag
    25081 gtaaggaaat agaagtaatt ataaaaaatg aaaagattga gtatgtgaat aatccaaact
    25141 taagagtgct tcatataaat cttgataagc atctaaattg ggctgctagt tgctgaaata
    25201 taatgaattt cttctggacg aagagtgatt ttgatgcttg gacaaacgaa gcgggattat
    25261 ctaatgatga agatatatat tgtttagata ttaatgaggc aatagtagaa tcatataaaa
    25321 tatttaaact caaacaaaag gtactatcat agatatacat atatgaaaaa ctaaaaatga
    25381 cctttagata aaaatgatag gtaatatcca tactatataa attagtatag agtagggatg
    25441 tgaaaagtat ttaaatctaa aggtatattt ttagtttttt ttagatgatt agatagcctt
    25501 attaagtata tatttattta taacctttgc aactccattt tcattattag tatcagtaac
    25561 ataatctgca atttccttta tactattacg tgcattcccc atagccacac caagacctgc
    25621 atactttatc atatgttggt cattttcttc atcgccaaca gcaatagcat tttctatagg
    25681 tatatttaga ttcgtacata atgttttaag agcagttcct ttattagtag ttttacctaa
    25741 aaattctaga taaaaaggag cagaccttac tatagtatat ttattgaata aatttttagg
    25801 tagttgctgt atgatttctt ccaatctttc tggttcatca actatcataa ttttacagat
    25861 tttaatagat tcatcaattt tatctttttg tatatatttg acttctatat tatttaattt
    25921 cgcttcatga agtgtatatt tgccaggcgt ttcatttggt gtaattaaat ttgtcattgt
    25981 atttatgtgt attttagtct tatatttttt acaaacgtta ttatatataa aatcaaaatc
    26041 atctaaactc atttctacat catgtatgat tttctcactt ttaacttctt gaataattgc
    26101 tccattaaag catataacat aatcaccttc atctgttaaa tttagttgat ttagaagttc
    26161 ttttacacca ggaagaggtc tgcctgttgt tataactact tttgccccag ccctttttgc
    26221 ctcctgaatg gactcaaaga cttcaggagt aatccttttt tgtgtattta atattgttcc
    26281 atcaatgtct agtgcgatta atttgtacat atcaacctcc aataaattat atactcaaat
    26341 ttcctgtgaa aacgttgaca cagctagtgt tgaacaaagt ttcagtggga aatatggttt
    26401 gttttgtata ctattatatc aagagataag taatttagaa agtttaataa tattaatttt
    26461 ttgataaaaa tattacttat gtgagatgag aatgtaaaaa ctttgtaatc aataattcca
    26521 aaattcttaa ttacaaataa tggtatcgtt tgcattgtta atataaataa atgtatatta
    26581 tatagttaga agtttgaata aatagactga tggtaatttg ttatattagt tagttttgtg
    26641 ttataaaata ttgtaattcc attaatcata tgttattatt caacatgatt ataatataaa
    26701 gaatatttga tatatataat aatttataaa agagtattac atagtacatg taaatctata
    26761 tttataaata caataaagta aagttgtaaa ggagtgcttt aaatgaagtt ttcagagttt
    26821 aagtatgaaa gacccaatta taatagtatg aaaaaagagt ttttgagttg tgtagaagat
    26881 ataaataatt ctcgtaatta taaagagcaa caaaaaaata tacataagat taatttatta
    26941 agaaataaaa tagaaacgtt gtcaaatata gcttcgataa gatatagtac agacacattt
    27001 aataaattct acaaagaaga aaaaaattat tgggatgaat atatgccttt gtatgaagaa
    27061 ttaaattcat atttttataa tgccattgta aattcaaaat ttaaatatga tttgataaaa
    27121 gagtttggag agcaattttt cacaatagta gagtattctt taaaaagttt ttccaaagaa
    27181 ataataagtg aattgcagga agaaaataaa ttgtgttcag agtatactag acttttagct
    27241 tcagctgaga taatgtttga tgggaaaata agaaatttat ctggtatggg gaaattcatg
    27301 tattctaaga atagaaaaac aagagaatta gcaaacaaag catattataa tttctttgaa
    27361 gaaaatgaaa ctaaatttga tgacatattt gataaattgg ttaaacttag agataagatg
    27421 tctaaaaaat taggttttga agattttgta gagcttgggt atgttagaat gatgagaagt
    27481 gactacagag aatatatgat aaaaaatgtt agaaaacaag tactaaaata tgttgttcca
    27541 atggcaaatg agctttatga aaaacaagct aaaagaattg gtctagaata tttaagttac
    27601 atagatgaag gcgtggaatt tttaacagga aatgcaagtt taaagggaga ttcaagatac
    27661 ataattaaaa atggtaaaag gatgtattct gaactgtcaa aagaaacaaa tgaatttttt
    27721 gattttatgt tagaaaatga acttatggat ttagaaacga agaaaggaaa aggagctgga
    27781 gggtattgta cttatatacc agattataag tcaccattca ttttttctaa ttttaatcaa
    27841 actgctgatg atatagatgt attaacacat gaggcaggac atgcatttca gttgtatatg
    27901 tctagatgga ttgatatgcc agaaattaat tttccaacgc ttgatagttg tgaaatccat
    27961 tcaatgagta tggaatttat aacatggccg tggatggatt tattttttaa agaagataca
    28021 gataagtaca aattcactca cttatcatct tcaattaaat ttatacctta tggagtaatt
    28081 gttgatgaat ttcaacacta tatttacaaa aatcctaatg tagataagtc aaaacgaaaa
    28141 gaaatctgga gatttttaga gaaaaaatac ttacctcata gaaaatatgg tgataattct
    28201 tttttagaga gaggttgttg gtggtttaaa caaggacata tatttaaaaa tccgttttat
    28261 tatatagatt atgtattagc tcaaatttgt gcgttacaat tttggaaaaa aatgattcaa
    28321 gatagagatg caggatggaa agattatata aatatctgta aagttggagg aacaaaatca
    28381 tttttagata ttgtgagtat gggaaatttg tattctccat ttgatgatgg ctgtattgag
    28441 tctattatag gtgatgttaa atcttggttt gatgaaataa atgacagcaa attataaaaa
    28501 attatgagaa ttttattgta taaaagtgaa aaattaaaaa atatataaaa agtgattatt
    28561 tgttgtgaaa atagtcttgt ttttaactaa attgataaaa taaactaaaa aagatttgta
    28621 cttaaaaaaa aaagaaaata caagaaatat gcaatatcaa catttggaaa aaaaagtaaa
    28681 aatgtataca aaatacatat aaaaaaacta ttgcaaattt tatagaatgt ttatatactt
    28741 aagtcaacag agatagaaaa aagctattta tagaaaacaa aggataaatt gcttaatttt
    28801 aaattttctg aaaaaaataa taatccggat gaagagtatg ggagactgct ttataaaaag
    28861 cgaccgaagg gacaagttta atcttactta cccaaaagat tagatgaaat tctcaggtaa
    28921 aggtgactgt acttggacgg ggctctgaaa atgattttaa cagggaagac aaattgggag
    28981 atttgttttt cctgtttttt atttatcaag taataaataa aagtttgaaa gagagtaaaa
    29041 aaatgataat aattacgaat aatccaaaag taaaagaaga agttcaaggc agagaagttt
    29101 tgtttaaaga cacaacttat attggaatct tagaagcaag tagagatttg atacatgaag
    29161 gttatgaact tttatctcat ccactctatg ggagtgtaaa gccaaatgaa acaccttaca
    29221 ggactgttat actaaagaaa ggaaatcgtt tggatataaa ctctttaacc ttaattgaag
    29281 aagcaatcat cactgcaagt aaatttcaga ataataaaaa gactccaaaa tggacagaaa
    29341 gtgttcaaga tgattttaga gtaattgatt atgatatatt ttataataca atacaaagaa
    29401 tgcagtatga ataaaaaaaa attgttaaaa agttattaaa acagcctaaa tattaaatct
    29461 aatttaatat taaataaaat gagaaattta attggggagg ataagtcaaa atggaaaatg
    29521 tgtatgactt agtaataatt ggttcaggac cagcagggct tgcagcaggt ctttatggag
    29581 caagagcaaa gttaaaaact ctaatcctag aaaaagacaa gactggtgga caaattgtaa
    29641 taacacatga aattgcaaat tatccagggt cagttccaaa tgcaacagga ccaagtttaa
    29701 tagctagaat ggttgaacag tgtaaagagt ttggagcaga aatgctaaga gacaacattg
    29761 ttgatactga gctagatgga gatataaaag ttttaaaagg ggaaaaggca gaatatagag
    29821 caaaagcagt aataatagga acaggagcaa caccaagaaa gattggttgt cctggagaaa
    29881 aagaacttac tggtaaaggg gtttcatatt gtgcaacttg tgatgcagat ttctttgaag
    29941 attttgaagt atttgttgta ggtggaggag acagtgcatt agaagaagca atgtatttaa
    30001 ctaaatttgc tagaaaagta acaattgtac atagaagaca aggatttaga tgtgctaaga
    30061 gtgttgaaga aaaagcaaaa gctaatccaa agatagagtt tttattagat acagtaattg
    30121 aagaaatcaa aggtgatgga atattagaat cagttgtatt taaaaataaa gttactggag
    30181 aaactcatga atactttgca gatgaagaag atggaacaat gggagtattt gtgttcgttg
    30241 gattagatgc tcaaactgat ttattcaaag gtaaagttga tatggatgaa aaaggttaca
    30301 taataactga tgaagatatg agaactaaca taccaggcgt atttgcagca ggagattgta
    30361 gatctaagac tctaagacag gttgtaactg caactaatga tggagcaatt gcatctatag
    30421 tagctgagaa atacattgat gaaaaatttg ggaactagaa tctgtaaatt aagaaatagt
    30481 gtctgtaaat ttaatgaata atatttaaaa ttaaaattaa tatttaaaat taaaataaaa
    30541 atttcaaggg ggaataagaa aatgttagat ttagataagg ctacatttga agaagaagtt
    30601 ttaaatgcag aaggttttgt atttgttgat ttttggagtg aaggttgtga gccttgtaaa
    30661 gctttaatgc cagatgttca taaattagct gagacttatg gggataaaat aaaattctgt
    30721 aagatggata caacaaaagc tagaagatta gctataaaac aaaaagtatt aggtcttcca
    30781 actatggcta tatacaaaga tggagaaaaa gtagacgaag ttactaagga tgatgctaca
    30841 gttcctaata tagaaaacat gattaaaaaa tatctttaat atgttgataa attattaaca
    30901 ttaaaagaaa aaatctattt ttatctgaag ataagaagaa aaaggttttt atgtccaact
    30961 ttgttaaaaa aataatttta aataaaataa tttttttaca ataaatattt tttagtaata
    31021 aaataaagat ttaaggcata aaaacacaat aatatatctt taaaaaaata agataaattg
    31081 taaaatgata taattttgag aaaaactcaa atgcatatac acaaattaaa taacaggagg
    31141 tgcaagtatg cgtcttgaat tagggaaaat ctttataaaa gatattcaat ttggtgatgt
    31201 aacagaagta aaagatggag tattattcat caataagcaa gagatgctac aagaaattgg
    31261 tggagatgag catattaaat ctatagatat agaattagct cgtccaggtg aaagcgtaag
    31321 aataacacct gtaaaagatg ttattgagcc aagagtaaaa gttgaaggta atgggggaat
    31381 cttccctggt atcatgtcta aagttgacac tgtaggagaa ggaaaaactc atgctttaaa
    31441 aggtgtagct gttgtaacta ctggaaaaat agtaggtttc caagaaggta taatagacat
    31501 gactggagaa ggagctaagt acactccatt ttctaaatta aataatgtag tagtaatagc
    31561 tgaacctatt gatggtttaa aacaatacgc tcatgaaaaa gctgttagaa tgataggatt
    31621 caaagcagca atgtacttag gagaagtagc aagaaatctt actccagatg aagtttcagt
    31681 atatgaaact aaacctcttc ttgaatcaat aaaagaatat ccagagcttc caaaagtagg
    31741 atatgtttac atgcttcaga ctcaaggttt attacatgat acttatgtat atggagtaga
    31801 tgcaaaacaa atagtaccaa ctttattata tccaacagaa ttaatggacg gagcaattgt
    31861 aagtggtaac tgtgtttctg catgtgacaa aaacccaagt tatgttcata taaacaatgg
    31921 ggttgttgaa gacttatatg caagacatgg taaagatata aactttgtag gtgtaattat
    31981 aactaatgaa aatgtttatc tagcagataa agaaagatct tcaaactgga cttctaaatt
    32041 atgtaaatat ttaggattag atgcagttat agtttcacaa gaaggttttg gaaatcctga
    32101 tactgacctt ataatgaact gtaagaagat agaaatgcaa ggtgttaaaa cagttatagt
    32161 tacagatgaa tatgctggac gtgatggagg ttctcaatca cttgcagatg cagatgtaag
    32221 agctgatgct gttgtaacag gtggaaatgc caaccaagtt gtagttcttc ctaagttaga
    32281 taaagttatt ggacatttag aagtagtaga tgtaatagct ggtggttctg atggaagttt
    32341 aagagctgat ggaactattg aagttgaaat ccaagctata acaggtgcaa ctaatgaaac
    32401 aggatttggt catttaactg ctaaaggata ttaagaagta ttttattaaa cgattgagta
    32461 atgttaataa aacatattat agataattat aataagtgtt atagatatat aaaaatatat
    32521 tagaaatata ataaggagga ttattatgag tttacttagt aataaaaagg ttcttataat
    32581 aggtgaccgt gatggtatac caggacctgc gatagaagaa tgtgtaaaaa cagtagaagg
    32641 agcagaggtt gttttctcat ctacagaatg ctttgtctga acagctgctg gggctatgga
    32701 cttagaaaat caaaacagag ttaaagatgc tgctgataaa ttcggagctg aaaatgttgt
    32761 gattttacta ggtgctgctg aagccgaagc tgcaggtctt gcagccgaaa cagtaactgc
    32821 tggagatcca actttcgctg gaccacttgc tggagttgcc ttaggattaa gtgtttacca
    32881 cgttgttgag gaaccaataa aatcattatt tgatgaaagt gtatatgaag accaaataag
    32941 tatgatggaa atggttttag aagttgaaga aatagaagaa gaaatgtctg gtataagaga
    33001 agaattttgt aaattttaat gcctaaaagc aaaaggggtg aaactaagag atgggaaaac
    33061 taaaagcagt acattatatt aatcagttct ttgctggtat aggtggagaa gaaaaagctg
    33121 atactaagcc acatgtggca gaaactttac ctccaataag tttacaactt gataaattat
    33181 taggtgaaga tattgaaata gttggaacag tagtttgtgg agatagctat ttcaatgaaa
    33241 atatagatag tgcaagtgaa gaagttttat caatggtaaa aggttttgaa ccacaacttt
    33301 tcatagctgg tcctgcattt aatgctggta gatatggggt tgctgctgga acaataacta
    33361 aagttgtaaa agatgctttg aatataccag ctttaacagg tatgtatgtt gaaaatccag
    33421 gagcagatat gttcaaaaag gatgtttatg tagtagaaac ttctgattct gcagcaggta
    33481 tgagaaaggc acttcctaag atagctaaac ttgcagtaaa acttgctaat ggagaagaaa
    33541 ttggaactcc taaagatgaa ggatacatag ctagaggaat aagagttaac tacttccatg
    33601 aagacagagg ttctaagaga gctgttgaca tgttagttaa gaaaataaaa ggtgaaccat
    33661 ttgaaactga atacccaatg ccaaactttg atagagttga cccaagtaaa gctgtaaaag
    33721 atttatcaaa atgtaaaata gctttagtta cttctggtgg tatagttcca aaaggaaatc
    33781 cagatagaat agagtcttct tcagcttcta aatatggaac ttattctata gcaggagtta
    33841 tggatttaac agaagagact tatgaaactg cacatggtgg atatgaccca gtgtatgcaa
    33901 atttagatgc agatagagta ttacctgttg atgttcttag agatttagaa aaagaaggtg
    33961 taattggaaa attacatgag actttctata caactgtagg taatggtaca tctgttgcaa
    34021 actctaaaaa atatgcttct gaaattggag cagcattagt ggctgatggt gtagatgcag
    34081 taatattaac ttctacatga ggtacttgta ctcgttgcgg tgcaacgatg gtaaaagaaa
    34141 tagaaaaaac tggacttcca gtagttcata tgtgtacagt agtacctatt tcattaacag
    34201 taggggctaa tagaatagtt ccaactatag caatacctca tccacttgga aatccagcgc
    34261 ttgaccctac agaagaaaaa gccctaagaa gaggccttgt agaaaaagca ttaaatgctt
    34321 taactacaga agtagatggt caaacagtat ttgaaaaata aaaataacac acacatatat
    34381 tatatagata aaaatataaa cacacactaa aaataaaaaa taactataca caaaaaaata
    34441 atatagattt catgaatgga taaattggag ttattcattc atgaaatctt aaaaaatgcc
    34501 aaaatacata aacaataata gaatcaaata tacaataaaa tacaatgatt agagctttta
    34561 ataagtttaa taagattaaa aaataagtgt tcataaaatt tatggaggtg cacaaaatga
    34621 cttatccagt tttaaaaggg gcaggctatg tacttattca tactccagat atgatagtgc
    34681 aaaatggaag tacttgtaca gttgaaagag caacaaatcc agattcagaa tttttaaaag
    34741 aagtaagtaa tcatataaga agttatgaag atgtagttaa ctacatgcca aatcaagttt
    34801 atataggaaa tagaagacca gaagaattaa gagatttacc aatgccatgg tgtgaacaaa
    34861 agattgaggg aactagaaat ggtaagtttg gagaaataat gcctcaagat gagttcatag
    34921 ctttaatgca aataagtgat gcatttgatt tagtaaaatt atcacaagaa tttattgatg
    34981 aagtaaagcc aaaaatcgaa aataactacc ctgaaattgc accatttgta ggtaaattaa
    35041 agggtgatga tatagaagaa ggtaaagaat tagtagcaac acacatagct gaaggattat
    35101 accatgatgg aaaatttgtt ggttatgtaa aaagagcaca tgatgtagat gttaacttaa
    35161 atgcccatac aatgtttgaa aatctagtag taaaagcatc tggagtttta tctgctattc
    35221 aaatgctaag acatagcaaa atagaccctg ctgaaataga ttatgttatt gagtgttcag
    35281 aagaagcttg tggagatata aaccaaagag gtggaggaaa ctttgctaaa tcaatagctg
    35341 agatagcagg acttcaaaat gcaactggtt ctgacacaag aggattttgt gcagcaccaa
    35401 ctcatgcatt aattcaagca gcagctttag taaaagctgg catacataaa aatgtaatgg
    35461 tagtagcagg tggagcaagt gctaaacttg gaatgaatgc taaagaccat gttaaaaaag
    35521 gtcttcctgt acttgaagat gttgttggag gatttgcagt acttgtatct gaaaatgatg
    35581 gtgtaaatcc agttataaga actgatttaa caggtaagca tactgttgga actggttctt
    35641 caccacaagc agttatgaca gcacttataa cttcaggtct tgatagagct aatttaaaaa
    35701 taacagatgt tgatgtgtat tcagttgaaa tgcaaaaccc agatataact aagccagcag
    35761 gagcaggaga tgttccagaa gcaaactaca aaatgatagg ggcacttgct gttaaacgtg
    35821 gagacttaga aaagaaagaa ttgaaagatt ttgtttctaa caaaggatta ccaggatggg
    35881 caccaactca aggacatata ccatcaggag ctccttatat aggattttta atagatgatt
    35941 taactacagg aaatagaaat agagctatga tagttggaaa aggtagttta ttcttaggaa
    36001 gaatgactaa cttatttgat ggagtatctt ttatagctga aagaaataca ggtgttactg
    36061 aagagacttc aggaatatct aaggatgaaa ttaagaagat aatagctgaa tctatgaaaa
    36121 aactagcatt agatatgtta gaagaatagg ggtgaggata tgtcaaaaaa agtaatcgca
    36181 gatgtattct tagaagtagc taatgcaata gaaagcggcg aatttggcaa aaaagtaaaa
    36241 attggtgtta ctacacttgg aagtgaacat ggtgtagaaa acatggttaa tggtgcacaa
    36301 ttagcaaaat ctaatttatt tgatattgtg cttattggac caaaagtgga aactgacctt
    36361 gaagtagttg aagttaatga tgaaaaagaa atgcatgcaa aaatggaaga attattagat
    36421 tcaggatata ttgatgcttg tgttactatg cattataatt ttccaatagg tgtatctaca
    36481 gtaggtagag taataactcc agcaaaagga aaagaaatga tacttgcaac aacaacagga
    36541 acaagtgcta ctaatagaat agaggcaatg gtaagaaatg ccatttatgg tattgctaca
    36601 gctaaatcaa tgggtaacaa atgcccaaaa gttggaatac ttaatgttga tggagcaaga
    36661 caagttgaga agtgcttaaa agaattaaaa gataatggat atgacatgga gtttgcggat
    36721 tcaattagag cagatggtgg atgtgtaatg agaggtaatg atttacttgt aggtgcacct
    36781 gatgttatgg ttactgatac attatctgga aatatattta tgaaagtatt ttcttcatat
    36841 actacaggtg gagattatga agctcaaggc tttggatacg gacctggagt tggagaggac
    36901 tatgatagaa aggtacttat agtatcaaga gcatcaggtt ctccggtagt agcaaatgct
    36961 ttaaaatacg cttatgatgt tgtaaaggga gatataagta atgttgcaag aaatgaattt
    37021 gcaaaggtta aaaaagcaaa atttgatgac attatatcct ctcttactaa aaaagaagtt
    37081 aaagctgaaa aagtagaagt taaaatgcca gataaagaaa ttgttactcg tcaaatagct
    37141 ggtgttgata taatggattt agaagatgca gtatctgagt tatggaaaaa cggaatctat
    37201 gctgaaagtg gtatgggttg tacaggtcca atagttttag taaatgaagc taaaggagac
    37261 ttagcagttg aaactttagt taaagctgga tatactgcaa aataagtaca ttttttatat
    37321 gtaaataaga acatatagtt ataattttat tgattataat tatatgttct ttttatttta
    37381 tatcttgtca atatttatat attaacacaa tccatttatt tgattctcta gctaatttat
    37441 tatatttatt caattaaaat taagctttct aactaaataa aaactaatga agtattaaaa
    37501 tgaaattgat aaaatatgaa aaaattttag gaataaagta tctgttagat aaaaataaga
    37561 ttaattagtg atataatata attaagataa aatttattat ttggaggtaa aatcatgagc
    37621 agagtaaaaa atgtagtaga attgttggaa actaaaggtg ttgatgcact atatctaaca
    37681 aagaaaacta atgtaaacta tataagtggt tttcctgatg aagaagcata tgcagtgatt
    37741 tgcaaagatg gaaacttttt agttactgat agtagatata tggagcttgc agaaaaggtt
    37801 tgcaaagatt ttgaaattat aaattggcat aattttgata gaagtgtggc aaaggcagtt
    37861 aaaagtgtat gtgataaagt gggtataaag aaacttggat ttgaaagaac taatatagtg
    37921 tttgataaat atgaagaact taaaaatctg attgagaagg ataatggaga attaatacct
    37981 acagaaaata ttgtagagac tttgagatat gtaaaagaca aagatgaaat caaaaataca
    38041 agaaaagctt gtgaaatagc ggataaggca ttagaagaat tgattccaca tataaaagct
    38101 ggagttagcg aaattgaact ggctacaagg ttagagtact ttatgaaaat gaacggagca
    38161 caaaatatag ggtttgaaac tatactgata tcaggagcaa agacttcatt gcttcatggt
    38221 aagcctagtg ataagattat agaaaaaggt gattttgtac ttatagacta tggtgctatg
    38281 tataatggct atatatctga tacaactaga acttttatag ttggaggagc ttctgaaaag
    38341 caattagaaa tatataattt agttaaggaa gctcaaaatg taggggttga gaacatgaaa
    38401 gctggtgtac atgcgacaat tccagatgct gagataagaa aagttgtcaa aaaatatgaa
    38461 gactattact atcaaggtat aggacatgga gtcggtagag atgttcatga agaacctttc
    38521 attggtaatt atggtgataa aatcatagaa gagggatgta taataacaat ggaaccaggt
    38581 atttatttcc ctggatgggg tggagttaga atagaagata ctgttttgat tactaaaaat
    38641 ggtccagaaa gacttactaa attccctaaa gatttgatga ttttagacaa ataatttaat
    38701 ttatatatat ttttttacat aaaatataac ataatctcac tattaagctc tatttacata
    38761 ttatagtaaa gagggcttaa ttttattgtg agaggtgata gtatatatgt ataaaaaaca
    38821 taaatttata aaaaatataa aaaaagcctg gtataaaatc aaattaattg atagatgcct
    38881 tataattgta atggcaatat taatgtttca atctatatat aacttatttg ttaatgaagt
    38941 aaattcacaa gatactacaa ctattgatgt agtagtaaga accacttcag cagctatatt
    39001 tgggtatttt ttaagtgcta attttataaa gagaccttta aggaagtata caaatactga
    39061 tgtatcttca aatcttttta tagataataa tttatcccca aaaggtcaag agtctaatca
    39121 aaataatata atgaatgtca aaaataccat tggatttact tcagaagctg ataattatga
    39181 aaagaaaata cctattaata ataatgaagg ttttgaagaa ggagaaacta gtgaattgca
    39241 aattattata gctactgtaa tttgcatagt agcattaaca gtactttttg ttgtaagaaa
    39301 ttttacaact acaacatcag cttctttagg tactatttca cagatgagag attttgtctc
    39361 aggatgcgtg ggttttttgc taggttgtcc aagtaaacct gattaaaaaa gtattatcaa
    39421 taaaaggtat tttaaaaagt atcagtataa taatatttag atttaaatgt atacaattat
    39481 aattctgtaa cattctatat tgtattttta tactgatact ctaaactata ctatttatta
    39541 aaatatttta acattgtatt taaacaaaat attatatctg tataatataa atttagttta
    39601 tatgaataga tgccatatac tcaataaaaa gtttcatact atgagatatg tattgatttc
    39661 ttctccaaag aaccccaata tttgcagtaa ttgcacgttc taatggtatt gaacagagat
    39721 tttctgtatt ttgaaatatt tctttataca atattgttga agccaagtca ttttctagta
    39781 aataacgtat ggtagaaagt tgatttgagt gtaaaattat atttggctta gctttttcaa
    39841 gtctttttgt aataatctta tagtgataag aaccttcaga taagattaca aaaggtacat
    39901 tttttaacat ataattcgat ataataggat gttttgccaa ttcatttttg ggatttgtaa
    39961 ctaagtataa ttctgtttta tagattgtct ttgaatctat atcatcataa atatcactgt
    40021 caattatacc aatacaaaaa tcaagtgtag attcttcaat cattttagct ccaacaaatg
    40081 ttggaacttc aaaaatttta agctctatat ctggataaat tacattaaac ctaggaagta
    40141 tttttgaaag caaaaacgta cctaaaactg taggaatacc tattttgaga gaagcttttc
    40201 tcttttttcc taaatcaagt gcgtcacatt gaaaatcctc aaattgtttt ataaaatgtt
    40261 ttgacttgtc taaaaaaatt tttccttcag gcgttaactc tattttatta cctattctgt
    40321 aaaaaagttc aaagccaagt tctttttcta attctttaat tgctaatgtt atggatggtt
    40381 gagaaatatg aatactttcc gcagccttag tcatgttttt atatttacag acagtttgaa
    40441 aatagtataa atagtttata ttcatttggt attagttcct ttcatttaca tattagtgac
    40501 aagtatataa ttaacaatag cataagtttt gtatattgtt gtaaaaaaat agaatagttt
    40561 taaactatca tagcataagt ttttgatatt ttcaatctat taagaatagt gctattatta
    40621 aattaacaaa agagaatagc tggtatggtt tagagtaaat caatctatat tacagttata
    40681 tcaacgaata tcaaaaaatt atctattaaa aaataaaaat tatttttaca attaaattgt
    40741 taattaaatc ataaagaaaa aagtgatatt aacaagataa aattttttta atcagaaatg
    40801 ttaatttaat aacaaaatag agtattgggg agaaaggaga aatatatttt ttaataatat
    40861 ttgttaattt aataacgaaa aatgaaaggg agtgatttag tgaagtttga attgatggat
    40921 tttttaatga atccttttgt ccttatgttt gctgcagtaa ttacaggaat tttatttgga
    40981 aaaattaaat ttgggaagtt taattttggg gtatcaggag cattatttac aggattattt
    41041 attggatggc ttgcatatag cttggggaat ctaataatag caaaagggga aacagcagca
    41101 ggatataagg cagcaactgt aatgatgggg aatggaatta tttcttctga cttctttgat
    41161 ttctttttaa taatatttgt tgcagcagtt ggtctattgg cagcaaaaga tatgaaagct
    41221 gtattaaaga agtatggagc aagatttgta attttaggag ttcttataac ttttataggt
    41281 ggctctatga cttatgcaat gactttacta tcaagtgata aaggaagtag tgcttatgaa
    41341 gtttctggcg tttacacagg agcattaaca agttcgcctg gattagctgc tgctttagaa
    41401 acagctggta aacatgcaga agatgtatca aaagaatttg aaaaagcttc aataaaagat
    41461 aaaaaagaaa ttttaaaagt agtcgaccca gaaggcaaat tggatgtgaa tacaactaca
    41521 tcactgactc aagagcaaat agataagtat attgcatatg ctgaagctgg tgttggtata
    41581 ggtcatgcag tcgcatatcc ttttggagtt ttaatagtaa tcttaggtgt aaatttcctt
    41641 ccaaaattat ttaggatgga cctaaaagaa gaaagaagaa aatatgagaa ggaaatgaag
    41701 gaagcaagag atagtgtttc tggtaaaacg ataccagaag ttccatttaa tataataaca
    41761 tttttcttga catgtttagc tggatactta gttggaggaa tacatgtatt tatgggacca
    41821 ctagggtact tcacactagg tgcaacagga ggttcactaa ttgtatctct agttcttgga
    41881 tatataggta agataggggt agtaaatttc agaatggaag aaaaggtttt aaatatttta
    41941 aaacaaatag ggctagtgtt tttcttagca atagttggat taagatatgg tggaaaagta
    42001 gttgattcaa ttatgacatc tggtatgcac ctagccttag tagcaatagc agtaggtgtt
    42061 acagctatga tgataggatt cttagttggc aaatacgtat ttaaattaaa ttggatttta
    42121 ttatctggag ctgtctgtgg tggtatgaca tcaacaccag gtcttggagc tgctgttgat
    42181 gctcttgata gtgatgaccc agcagcaggt tatggtgcta cgtatccatt tgcattatta
    42241 actaaagtta tattggttat agttttacac aaacttccaa tgtaaataag attttatatg
    42301 gggggatatt tatgaataat gaaggagcat ttgaagaatt aagtggaaga ttaagaaata
    42361 aagaattgtg tgatttaata atgaatgcag atgaagctgc taaaattata gaggatggca
    42421 tggttattgg agttagtgga tttacacctt caggctatcc aaaagcagta ccattagcag
    42481 tttcagaaag agctaaaagt ggagaaaaga taaaattaac cgtatattca ggagcatctt
    42541 taggtccaga agttgatgga gcatggtcag aagcaggtat aattgaaaga agacttcctt
    42601 atcaaactaa ttcaatactt agaaataata ttaataaagg tgttgttgat tatatagata
    42661 tgcacctaag tcattctact caatttttaa attatggaac tatacctaaa gtagatgtag
    42721 ctatagtaga agcacttgca ataactgaag aagggaatat tataccaact agtgggatag
    42781 gtaattctcc atcttttata aaaagtgcag ataaagtaat agtagagata aatcttgcaa
    42841 aaccaatgga aatggaaggt atggcagata tatatattac ggaaaatcca ccaaatagaa
    42901 aaccaataga aataaatcat cctaaggata gaattggaac aacatatata ccttgtggtt
    42961 tggataaaat tgcaggagta gtaattacca atatgcaaga taagacccgt ccattggggg
    43021 ttgtagatga agcttcgaaa aaaatatcaa ataatattat tgctttttta agagaagaag
    43081 taaagtcagg cagattatca aagaatttac ttcctcttca atctggtgta ggaagtgtag
    43141 caaatgcagt attatatgga ttatgtgaat ctgaatttga aaatttaact tgttatacag
    43201 aggttgtaca ggactctatg ttggatttaa taagaatggg taaagttaca atggcatcta
    43261 ctacatctgt aagtccatct ccagaaggat taataaaatt tgaaaaagat attgattttt
    43321 ttaaggataa gattatatta agacctcaag aaattagtaa caatccagaa atagccagaa
    43381 gaattggtgt aattgcaatg aacactgcaa ttgaagttga tatttatgga aatgtaaatt
    43441 ctactcacat aatggggtca aagatgatga atggaattgg tggttctggt gattttgcta
    43501 gaaatggagc aataactata tttagtactg agtcaattgc aaaaaatggt gatatatcat
    43561 caatagtacc tatggtatct cacgtagacc acactgaaca tgatgtaatg gtaattgtaa
    43621 cagaacaagg atatgctgat ttaagaggtc ttgcacctag agaaagagct ataaaaataa
    43681 tagaaaattg tgcccatcca gattataaag aacaacttag ggattattta aatagagctt
    43741 gtaaaagtgg agcaaaacaa acacctcaca tattggacga agctttatca tggcatagta
    43801 aatttatgag tacaggtaca atgaaaaagg ctgaaacttt taaaagtgca ttataaaata
    43861 tttaataaat tggaggtaga ttttaaatgg aaaaagcagt ggaaaacttt gaagatttaa
    43921 gtaaggaata cattaatggt tatattgaga gagcaagaaa agctcaaaga gagtttgaat
    43981 gttatactca agaacaagta gataaaatag taaaaatagt tggaaaagta gtgtattata
    44041 atgctgaata tttagctaaa cttgctgtag aagagactgg aatgggagta tatgaagata
    44101 aggtagctaa aaataaaagc aaagcaaaag ttatatataa caatttaaaa gataaaaaat
    44161 cagttggtat aattgatata gatagagaaa ctggaataac aaaggtagct aaaccagttg
    44221 gagtagtagc ggcaataact ccttgtacaa atccaatcgt tacacctatg agcaatgcaa
    44281 tgtttgcact taagggaaga aatgcaatta ttatcacacc tcatcataaa gcaattggat
    44341 gtagtacaaa aactgtagag atgattaatg aagaattaga aaaaatagga gctccagaaa
    44401 atttaataca aatacttgac caacaatcaa gagaaaatac aagaaattta atttcatcag
    44461 cagatgtagt aattgccact ggaggaatgg gaatggtaaa agctgcgtac tcaagtggaa
    44521 aaccagcact tggtgtaggg gcaggaaatg ttcaatgtat catagataga gatgtagaca
    44581 ttaaagaagc agtacctaaa atcatagcag gaagaatttt tgataatggt atcatttgtt
    44641 caggtgaaca gtcagtaata gtagcagaag aaatgtttga taaaataatg gatgaattta
    44701 aaaataataa aggttttata gttagagata aagtacaaaa agaagctttc agaaatgcta
    44761 tgtttgtaaa taaatctatg aataaagatg cagtaggtca atcagttcat acaattgcaa
    44821 aaattgcagg tgttgagata ccagaagata caaaaataat agtaatagaa gctgatggac
    44881 caggagaaga ggatattatt gcaaaagaaa aaatgtgtcc agttatatct gcatacaagt
    44941 ataaaagttt tgaagaaggt gtagctattg caaaagcaaa tttaaatgta gaaggaaaag
    45001 gacatagtgt atctatacat tcaaatacag ttaaaaatat agaatatgca ggagaaaata
    45061 tagaagtatc aagatttgtt attaatcaat gttgtgctac tagtgctgga ggaagtttct
    45121 ttaatggtct tgcacctact aatactctag gttgtggttc ttggggaaat aacagcatct
    45181 ctgaaaatct tgattataag catctaatta atatttctag aattgcttat tatatgccag
    45241 aaaatgaagt ccctacagat gaagaacttt ggggataaaa tttagacaaa aaatattcat
    45301 tctaaattaa agtaggaata tattttaatt tagaatgaat ttaagacata aattaaattt
    45361 aaattagttt attggactaa atttaaaata ttaagagaca tatagaagaa ggaagtatta
    45421 taatttaaaa taaataaaaa aatctataaa agagaaggag tggttttatt atggcattaa
    45481 tgacaggagc tcaatatatt gaaagtttga gaaaattaaa tactaaggtt tatatgtttg
    45541 gtgaagaggt taagaattgg gttgaccatc ctatgattag accatctata aattgtgtag
    45601 cagcaactta tgacttagct catgacccag aatatgcaga tttaatgaca gttacttcaa
    45661 atatcacagg tgaaaaaata aatagatttg gtcatcttca tcaaagtgtt gatgatttga
    45721 taaaaaaagt aaaaatgcaa agactatgtg gtcaaaaaac agcttcttgt ttccaaagat
    45781 gtgttggtat ggatgcgttt aatgcagtgt attcaacaac atttgagtgt gataaagccc
    45841 atggaactaa ttatcatgat aattttgtaa aatacttaac ttatatacaa gaaaacgatt
    45901 tagtagttga tggagctatg actgacccta agggagatag aagtctatca cctagtgctc
    45961 aacctgaccc agatatgttc cttcatatag tagaaagaag agaagatggg ataattgtaa
    46021 gaggagcaaa ggcacatcaa actggttcaa taaattcaca tgagcacctt ataatgccta
    46081 ctataagtat gactgaagca gataaagact acgctgtatc atttgcagtt ccttcagatg
    46141 ctgaaggagt gtttatgatt tatggaagac aatcttgtga cactagaaaa ttagaagaag
    46201 gtgcagatgt tgatttagga aataaggagt ttggaggtca agaagcttta gtagtatttg
    46261 ataatgtatt tgttccaaat gatagaattt tcttatgtgg agaatgggat ttctctggta
    46321 tgttagtaga gagatttgca ggataccata gacaaagtta tggtggatgt aaagtaggag
    46381 taggtgatgt aataatagga gcagcagctt tagcagctga ttataatgga gcaaacaaag
    46441 cttcacatat aaaagataaa ctaatagaaa tgactcacct taatgaaagc ttatattgct
    46501 gtggtatagc atgttcatca gaaggtcaca aaacagaagc tggaaactat caaatagatt
    46561 tacttcttgc aaatgtgtgt aaacaaaatg taactagatt tccttatgaa atagtaagac
    46621 ttgcagaaga tatagctgga gggcttatgg ttactatgcc ttcagaaaaa gactttaaat
    46681 cagaccttaa agttggaaca agtggaatga ctattggcga agtatgtaac aagtatttta
    46741 aagcttcttc agtggcttca acagaagaaa gaatgagaat attaagattc ttagaaaata
    46801 tatgccttgg ttcatctgct gttggttata gaactgagtc aatgcatggg gcaggttcac
    46861 cacaagctca aagaataatg atttcaagac aaggaaacat aaatcaaaag aaagaattag
    46921 ctaagaaaat tgcgggaata aaaaaagagg aagctttaaa tttataaaaa gttgatatat
    46981 aaagggaaat tatatattaa tgtgtattaa ttaatgaaaa aatatgtagt ataagagata
    47041 gttataaaat tatggtggtt tttagctaag taaagaaatt tttaataagg agaatttaca
    47101 catgacctgt ggagttagat tttgtggggg ctgtaaccct agatacgaaa gagggaaggc
    47161 tcttacaata atcaaagagc acttcaatgg tagggtagat tttagtatag cacaagagaa
    47221 cgtcgagtat gatttgctac ttataattgg aggatgcgca actctatgcg catcctatca
    47281 acaatataaa gtgaaaaatg aatgtgttaa gatgtgggat tttagccata tagaaagagt
    47341 tataaatgtg attgaatcag caatttgtga aacttaaaaa agctaaatgg ggggatttca
    47401 ttgagttggc aagaattgta tcaaagtaaa ttatgtagtg ctacagaagc tgtaaaacag
    47461 attaaaaacg gtgatactgt agtatttgca cattgtgtag gtgaacctcc tgcactagta
    47521 gaggctatga ttgaaaatgc tgaacaatat aaagatgttg agattaaaca tatggtaagc
    47581 ttgggtagtg gtggatatac tgctaaggga atggaagctc attttagagt aaatccaatg
    47641 tttgtaagtg gaaatgtaag aaaggcaatt gaaaatggag atggtgattt tacacctgca
    47701 ttcttccatg aagtaccaaa gttgcttaga gaaaaaagat taaaatgtga tgttgtttta
    47761 gcacaggtaa ctccaccaga tgaacatggg tattgtagct taggaacatc agttgattat
    47821 acttatgaag ccattaaaac tgctagaaca gtaattgttc aagtgaatga ccagtttcct
    47881 agaacctatg gtgaggtagt ccatgtatca gagtttgact atatagtgga aaaatcacaa
    47941 cctttatttg aactacaacc tgcaaagatt ggagaagtag aagaagcaat tggtaaaaat
    48001 tgtgcttcat taattgaaga tggttctact ttacagctag ggattggtgg gataccagat
    48061 gcagttatgt tatttttaac tgataaaaag gatttaggga ttcattcaga aatgatttca
    48121 gatgggactt tggcccttta tgaaaaaggt gttataaatg gtaaatataa aaattttgat
    48181 aaagaaaaaa tgacagttac cttcttaatg ggtactaaaa aattatatga ctttgcaaat
    48241 aataaccctg cagtagaggt aaaaccagta gactatgtga atcatccagc aattataatg
    48301 aaacaacata agatggtttc tataaattct gctatacaag ttgatttaat gggacaggta
    48361 gttgcagagg ctatgggact tagacaattt agtggtgttg gaggtcaagt tgactttata
    48421 cgtggagtgt ctatgggtga agatggaaag gcaattatag ctatgccttc aataactacg
    48481 aaaaaagatg gtacagtaat ttcaaaaatc gtgtctattg tggatgaagg tgcacctata
    48541 acgacatcaa gaaatgatgt tgactatatt gtaacagaat acggtatagc agaattaaaa
    48601 ggaaaatctc ttagagaaag agcgagaaat ttaataaata tagctcatcc aagtgtaaga
    48661 gaaagtctag cagtagaatt tgaaaagaga tttaaggaga aatattaata atagaggggt
    48721 gttaataatg gaagcactta gagtagttcc aaagatattt tactttgata catttaaaga
    48781 atttaatgaa gaatttaaaa taggaaaaaa tgatttagta attactaatg agtttatata
    48841 tgagccatat atgaaacctc ttggaataga tacaaattta atttttcaag aaaagtttgg
    48901 aacaggtgaa ccatctgatg aaatgataga ctccatgaca aaggaaatga agaaatacaa
    48961 ttttgataga attattgcat ttggaggagg aacaatagtt gatatatgta agatattagc
    49021 acttgatgtt ccagaaaagt ctattgattt atttgaagga gaagtatcac ctaaaaaagt
    49081 aaaagagtta gtagtagttc ctacaacatg tggtacaggt agtgaagtaa caaatgtagc
    49141 tattgcagag ttaaaatcta aacatactaa aaaggggctt gcagtagaag aaacatatgc
    49201 agactatgca gtgttaattc cagagacagt aaaagggtta ccttacaaat tctttgttac
    49261 aagttcggta gatgctctta tacatgctat tgagtcttat ctttctccaa aagcaagtcc
    49321 atttacagag atgtattctc tacaagcaat aaaaatgatt atggatgggt ataagaagat
    49381 agttgataaa ggagaagaag agagatttaa tcatcttaga gactttgtac ttgcatcaaa
    49441 ttatgcagga attgcttttg gaaatgctgg ttgtgcagca gttcatgcac tatcttattc
    49501 aataggtgga gctttccatg ttgcacatgg tgaagcaaat tatcagttct ttactgaagt
    49561 atttaagatg tattctagaa aaaaacctaa tggaaaaatt ataaaatgta caaaaatttt
    49621 agcagatgcc cttgaatgtg accctaactg tgatgtttat ggagaattag aaaagttttt
    49681 aaataaatta atagctaaaa aagctttgag agaatatgga atggtggaaa gtcagataga
    49741 tgaatttaca gatagtacaa tagcaaatca acaacgacta cttgctaata attatgtaga
    49801 gcttagtaga gaggaaataa gagagatatt tgcaaatctt tattaataca attttttatt
    49861 tatatgtata gtcaacataa acaatgctaa ttatatttat gtacaaataa aaataaggga
    49921 acttaaattt taattaaagt taagttctct tatttttata tggagttaaa tataagtata
    49981 tttttaattt aaaatatgct tatatttaag tctattactt tatttgaaac aatttgtaga
    50041 atttcaaatt ccttgacagt aataagtaag taattgtata atcaaactgc aatatattaa
    50101 taatattagt gaaaatgaaa ggattataaa atatgtataa atcagaaaat ttttcaaaaa
    50161 aatctgtatt aataaattca tttttaagta aatttttaaa aataattgga tggggtttgg
    50221 taagcttatt tacattatca gccttagtac tttcaactat ttccattata attggatggg
    50281 ctgtaatact tcctattcaa gtatgtgcag tatttttact tataggagga gtttgtattt
    50341 ttaaaggtaa gagattagga gaccaaattt ctcgttataa aaaatattgt acaattataa
    50401 acaatagaaa tattattcca gtagaactta ttgcagaaaa cacatctaaa tcattaaatt
    50461 ttataataaa agatgtacaa aagatgatag acaaaaacta ctttataaat acttatattg
    50521 ataaaagaaa taatcagatt gtgttaacaa atgaagattt tgttccacca agatatgaag
    50581 atgtagcata tgaagtcaaa gaagaagaaa agactgatga atccaatgaa gttgatacaa
    50641 ttataaataa aggaatgaat tatctaacac aaataaaaga agctaataaa aatattaaat
    50701 cagaatcaat gggcgataaa attgtacaag tagaagatgt tacaagtaaa atatttgatg
    50761 ttgtaaaaca tgacccatca aaacttactc aaatacaaaa atttatggat tattatcttc
    50821 caaccacttt aaaactatta aattcatatc atacattgga agaacaagga attgatagag
    50881 aaaatataac aacaactatg gaaagtattg aaaatacaat gaatacgatt gtagtagctt
    50941 ttgaaaatca attggactat ctgtttgaag atgaagccat tgatatttct acagatatta
    51001 ctgttttaga gaatatgtta gtccaagaag gattaacgag tggtaaattt taacttcaat
    51061 agaaaaaata ttctgttatt tttaaacaat taattagtca taaagtataa aatgtgtatt
    51121 atataagtta atcagtactt tatgaaggaa gaggagagaa agatacaatg aataatttag
    51181 atgatatacc agttatgcca actttgacac ttgacccatt tggagaagaa tcaaacacta
    51241 atgatataga taattctgac ttattaatga aaaaggatga aaaagaccca gaagaagaaa
    51301 aactgtctga atctgaacgc aagatggtaa aggaatttgc ggaaaaaata gatattacaa
    51361 atacaaatat gattttgcaa tatggagctg gtgctcaaaa aaaggtagca agtttttctg
    51421 aaacagcttt aaagagtgta aagacaagag atttaggaga agttggagat atgcttacaa
    51481 atctagttac tgatttaaaa gcattttcag cagatgaaaa agaacaaagt ggttttttag
    51541 gaatttttaa aaaggcaaat aataaaattt caaatttaaa aactaagtat gatagtgcag
    51601 aggtaaatgt ggataaagta agcaaagagc ttcaaaagca tcaggttaaa atattgaaag
    51661 atatagcaat gcttgataag atgtatgaat tgaacttagc ttactcaaaa gagcttacta
    51721 tgtatattat agcaggaaaa caaaaattaa aggatatgaa agaatatgag atgccaaagt
    51781 tgagagaaaa agctcgttta tctggttcaa cagaagatgc tcaatctgta aatgatatgg
    51841 tttcactttg tgacagattt gaaaagaaga ttcatgactt agaattaact agaatggtat
    51901 cgcttcaaat ggctcctcag ataagattgg ttcaaaatag taataatctg atggcagaaa
    51961 agattcaatc aactatagta aataccattc cattatggaa aaatcaaata gtgcttgctc
    52021 ttggaatttc tcacttaaat caagctatga aagcacagcg tgaagttagt aatatgacaa
    52081 atgagctttt attaaagaat gcagaaactt tgaagatggg aacaatagaa acagcaaaag
    52141 aatcagaaag aggaattgta gatatagaca caattaagaa aactaatcaa tctctaatat
    52201 ctactattga tgaggtagtt aagatacaac atgatggtag aataaagaga caagaagcag
    52261 aagttgaatt atcaaaaata gaaaatgaac ttaaaagcaa gcttcttgaa tttacagtta
    52321 aataaaaatt atactaagat aaaaagagac tgtctcaaaa ttggatatgt ccctgtcaag
    52381 tagacagact taaaaaaggc tatctttact cggaatgagt tcgatattca atcggactca
    52441 ttccgttttt taattgtatt ctttcattat tataaaaata aatataatca tttattagac
    52501 taatcatttc ctttggatct gtagtatcaa ttaaatatat taattcagat ttaaaatgac
    52561 tgaaaaaact ttctatagga gcattatccc agcagttgcc ccttcgggac attgattgta
    52621 taataccatt atccttaagc cttttagagt aagatctact tgtatattgt gaaccttgat
    52681 ctgtatgtaa aatacaatct ttagctaaat tcatatttat tagttgattt actgtattat
    52741 taactaattt agtatccatt tttgtactta tctcatatgc cactatttca ccattaaata
    52801 aatctttggc tacattcata tataagaatt ttttaccgat aggtatgtat gttatatcca
    52861 tacaaatttt ttctaatggt tgattagctc taaattcacg atttaatata ttatcatata
    52921 tctcatatga tttaaactta cgtctatata ctttctttct aataatagat ttaataccta
    52981 gttctttcat caacctatat actctcttat gattaatagg ggtatcaagt attttattta
    53041 aataagtaca aattcttttt ctaccataag ttcctctata ttttttatgt atttcaatta
    53101 tataatcctt aataattcta tctttgatac ccctatcgga agatttttta gaataactta
    53161 gccatttata gtaaccgctt cttgacacac ttatcaactt acacatacta gaaatactat
    53221 acttcctaga cagaagttta attgttttaa atttatcgct tactttgact tgtccaatag
    53281 ggtacttaac ttttttaaga attcattctc catgcgtaag tacttcaatt cttcttcaac
    53341 agatttaaat tttctattat cattttctag actaatattt ttaaatctgc ccctagtttc
    53401 atcatcaaat gcagttttgc ctttattttt ataatctttt acccagtttt gaacttgtgt
    53461 tttgcttctt atattcagca tctcagcaat tttgtatgat gagtatcctt cttttatata
    53521 taagtttaca gcttttagct taagttcttt gctatatttt ttgtgttttt tagacataga
    53581 aaaaccccct tagagtatac gctttttaga cctattataa tagcctttta tttaaatgtc
    53641 tactataagg ggattatact aaaatagaga taagtctctt tttcattgtt taaatgatta
    53701 aagtatattt atattataaa tttctattat cttttaacat aacatcatga gctccacctt
    53761 caactatact agtagaagat acaagtgtaa gtttagcatt tttttgaagt tcaggaatgc
    53821 taagtgctcc acagttacac atagtagaac gaactttact taaagaaaga gttacattgt
    53881 ctttcaaaga accagcataa ggaacataag agtcaacacc ttcttcaaaa gaaagtttct
    53941 tatctccacc aaggtcatat ctttgccagt ttctagcacg agcagaacct tctccccaat
    54001 actctttcat ataactacca tttatattaa ctttgttagt tggactctca tcaaaacgag
    54061 agaagtatct accaagcatt ataaaatctg cacccatagc taaagctaaa gttatatgat
    54121 ggtcataaac gataccacca tcagaacaaa ttggaatata aatacctgtt ttttcaaagt
    54181 attcgtccct agcttgagca acttcaatta tagaagtagc ttgtccacgt cctatacctt
    54241 tttgttcacg agttatacat atagaaccac caccaatacc aactttaacg aagtcagcac
    54301 cagcttcagc taggtaaagg aatccctcac ggtcaactac atttccagct cctaccttaa
    54361 ctgtatcacc atatttttca cgaatgaaat caagtgttat tttttgccac tcagaaaaac
    54421 cttctgaaga atctatacat aaaacatcag caccagcttc aactaaagca ggaacacgtt
    54481 cagcaaagtc tctggtatta ataccagctc caactacata tctcttagaa gaatctaaaa
    54541 gttcaagtgg attttcttta tgagaagagt aatctttacg gaataccata tacataagat
    54601 taccattgtc atcaagtaca ggaagagaat taagtttgtg gtcccatata atgttgtttg
    54661 cttcctttaa agtaacatct ttgttagcat aaactataga tgacatagga gtcataaatt
    54721 cactaacttt agtatctaaa tccatacgac ttatacgata atcacgactt gcaacaatac
    54781 ctaataattt accagttgaa gttccatctt cagtaacagc tactgtagaa tgtccagttt
    54841 tttcttttaa gtcaagtatg tcttttaatg tgttatcagg tttaatattt gaatcactta
    54901 caacaaaacc agctttgtgg gatttaacac gtgctaccat agcagcttca tcttcaatag
    54961 tttgagaacc gtatataaat gaaataccac cttctttagc aagtgcaata gccattttgt
    55021 catcagaaac agattgcata atagcagaag tcaaaggtat attcatataa atatctgctt
    55081 cctcgccctt tttaaattta gtaacaggtg tttttaaact tacattagca ggtatacaat
    55141 cagtagaaga gaaacctggt acaagaaggt attcactgaa agtatgtgat ggtgtatcaa
    55201 aataaaacgc cattttttaa tcactcctta tatttttata ctttttataa ttgatagtat
    55261 taattataac ttattcttta attttattaa agtattttgt caaatattga gatttttgaa
    55321 aaatttaaac tattttaatt gaatttgttt aatatatatt gccttatagg gtaaagttgt
    55381 atattaaata atgtttagtg tttaatagta gctaatttga aattaatctt tagttattca
    55441 tataattaca tttgtatagt ttatattgat aatattgcta gagagtgcat aaacctcaaa
    55501 aatacagata aattaaatct atattagtat atccaaaagt acatttaata aatttattta
    55561 actgaattat tattttcatt tctattaaat ttaaatattt tataaaaata gtattattta
    55621 caaaatcata tactccaaaa tactacataa ataaaattaa acaaaaacta aaatgacaaa
    55681 tgtcattatc taaagtgaca tagaaacggt ttcttaaagt tgttactata aaatataaac
    55741 tctataataa aagtataaca aaagggaatc atatcgatat agaatataat tcaagaggag
    55801 gtaaaattat gagtagttct aatcaatcga caataaagac atctatacag cgagtaggga
    55861 aatttttaag tggtatggta atgccaaata taggagcttt tatagcatgg ggtcttataa
    55921 cagcattatt tataccaaca ggatggatgc ctaatgaaaa attgagtact ataggcgacc
    55981 caatgataaa atacctttta ccactattga tagcttatac tggtggtaaa gcaatagcag
    56041 gacaaagagg tggcgtaata ggtgcagcag cagctatggg agtaattgtt ggggcagata
    56101 taccaatgtt tatcggagca atgataatgg gaccatttgc aggatgggta attaagaagt
    56161 tcgataaatt tgtagatgga aagataccaa caggatttga aatgttagta aataactttt
    56221 caataggtat aataggtatg cttcttgcaa tactaggatt ttatgcaatt ggaccagcaa
    56281 tagtagcagg gacagctctt atagaatctg gagttcaatt tatagttagc aaaagtttat
    56341 tgcctttagt ttcagtattt atagaacctg gaaaagtatt attcttaaac aatgcaataa
    56401 atcatggtat attagggcct ataggtatag ctgaggcaaa agaagcaggt aaatctataa
    56461 tgttcttact agaaagtaac cctggaccag gtttaggagt tctattagca tattggatgt
    56521 ttagtagagg aagtgtaaaa caatcagcac caggagctgt aataatacat ttctttggtg
    56581 gtatccatga aatttacttc ccatatattt taatgaatcc agttttaata ttggctacaa
    56641 tggcaggtgg agcagcagga atattgactt tttcaatatt aggagctggg cttgtagcag
    56701 caccatcacc aggaagtata tttgcactta tggcactagc tccaaaggga ggattacttc
    56761 cagtattagc aggggttgca gtggcaacag ttgtatcatt cttagtggca gcaccatttg
    56821 ttaagagagc ttcagcaaat gaaagtgaag aagacagtac ttctttagaa gaagctaaag
    56881 caaaaatgag tgatatgaaa tctgcaagta agaactctga gaaaaatatt gagaaaaaac
    56941 agcttgaagt aaatgagatt aagaagattg tatttgcatg tgatgcagga atgggttcga
    57001 gtgcaatggg agcttctaga tttaaaaata gaataaaaaa cttagattta gatatagaaa
    57061 ttacaaattc atctgttgat aatcttccag atgatacaca aatagtagta actcacaata
    57121 cattagttga aagagttgct aagaacaatt caagtgttga gatagtttca ataaacaatt
    57181 ttttaaatga cccaaattta gatacattat ttaaaagatt agaatctaaa taaaaataaa
    57241 aagtaccact aattaggagt ggataatttg aaaaaaaaga agattacatc taggcaaaaa
    57301 aagataatac taatgatagt agaaaattca aagaaaaaca ttccaataac tatttctgag
    57361 attgcaggga cgttagagtt aagttcaaga actgtactta gagatatgtc tggaattgaa
    57421 aaatggtttg atgaaaatga ttttaacttt gtaaaaaaac caggagtagg attgatttta
    57481 gaggaaaata tagaaaatca aaactttata attgagttgt tagaagaaga aaaaatagaa
    57541 aaagaataca gcaaggaaga aagaaattta attatattat caaagctact agtttctaac
    57601 gagccagtaa aatcttatta ttttgcaaaa atattaaagg tatctgaagg ggtactgaat
    57661 aatgattttt cattagcaag taaatggttg gaaagatttg atattgagct tgttagaaaa
    57721 ccagggcttg gtgtctacct aaaaggtcaa gaaaaaagct ttagagaggc atatgtaaat
    57781 cttatatacg attcattcaa tgaaaaagaa atactagata tggtcagaaa tataagtgaa
    57841 aatatacaaa cagataaagc aatagaaatt ttaagtgaaa atagactttt aaatttaatg
    57901 gataggtgca taataataaa agttgaagct acattaacaa agaagctttc agatttagat
    57961 gtaaatttag ctgatagtgc atatataggg cttgtagttc atatttcatt agccttacag
    58021 aggataaaaa atggtgaaaa tataactatg gataaagagt ttctaaaaga attatctata
    58081 acagaagagt ttaaattagc taaagaaatc gtaaaaggta tggaaacaga ttttaacatg
    58141 gatataccag tagatgaggt tggatatata actatgcata taagaggtgc aaagcaaagg
    58201 tcatcttcaa atcataaggc tttaaacttg gatgatatag aaataatgga aattacaaat
    58261 aagatgatag atttggctga agatgaattt aaaataagtt taaaaaatga cgagaggtta
    58321 tttaaagacc tagcaaatca cttaggacct tctataaata gattgaatat gggattagaa
    58381 ataagaaatc ctcttttaga tgaaataaaa agcaagtatt catatgccta tgatggagtt
    58441 gaaaaaattt ctagaattat aaaagataaa ctaaatataa attcaatacc tgaatcagaa
    58501 ataggatata ttgcaatgca ctttgcatca gccatagaaa aaaatcttat gatgaatact
    58561 aatataaata ttgttgtggc atgtcccact ggaataggta cttcaagatt cttatcaact
    58621 aagattgaaa ataaatttcc taatttaaat atacttgaaa ccatatcagc tataaacata
    58681 gatgaagagt atttaaaggg aaaagatgtt gatttaatag tgtctacagt tgagttaaat
    58741 acaagtttaa attatatatg tgtaggtcca tttatgagtt tagatgatga acagataatc
    58801 aaggaaaaaa taaaatctat agctcaaaat aaattaatta atttaaatac aaaaaatgat
    58861 actaaaagta agaataaagt atatgaacag ataacagaaa gtatgaatat aggaaaagat
    58921 attcttcaat ttttagagga aattagattt gaaaaatttg aaagtaaaga tttaagtgag
    58981 cttattgaag actcatcaaa aatatttgca aaatctagtg aagatataat gtctataaaa
    59041 gaatcgttaa aagaaagatt aaaaatctca attccatata tagaagaatc aaaaattcta
    59101 ttattacatt gtatgagtga aagaatagat attatgaagt tatcaataat aaaactggag
    59161 aatcgaatcg tgctagattc aaatgaagaa atcgacaatg tagtttttat gttacttcct
    59221 aaaaattcac caagttatca aagacaaata atgagtgaaa taagtggttc attaatagac
    59281 aatataattt ttactaataa gataaataaa ttctctatag aagagatgac attagaggta
    59341 aaagatatag tttttaattt ttatacaaac agattaaaag catttataga tgaataaaat
    59401 taatattaaa aaggaaggtt gatactatga gtaaagtatt gaatgagaat aatatatttt
    59461 tagggttaga tagtgtttca aaggaagaag ctataacttt agcaggaaga aaattagttg
    59521 aaaatggata tgtaaaagaa gaatatatac cagcaatgct agaaagagaa aaagtaatga
    59581 ctacatatat gggaatggga gttgctattc cacatggtgt aaatgaagca aaaaaagaaa
    59641 tattatcttc tggaatagtt atactacaat tccctaatgg tatagatttt gatggagaaa
    59701 aagcatactt attaatagga atagctggtg ttggagatga acatttagaa atactatcta
    59761 atatagcagt agttttagat gatgacttaa cagaaagact aaaaaattca aatgacaaac
    59821 aagcttttat ggaagctttt gccaaataat cttaggaggg atttaaaatg aaaaaggcaa
    59881 tccagtttgg agcaggaaat attggaagag gttttattgg aggcttgtta gttaagtcgg
    59941 gttatcatgt agtatttgct gatgtaaatg aggagatatt aaactcaata aataaagata
    60001 aaaagtatac tatacacata agagatgtag aatgtataga tgaagtaatt gataatataa
    60061 gtgcggtttc atctataaaa gaagaaataa tagatgagat tgtacaggct gaaataataa
    60121 ctacagcagt tggaccttta gttttgacta aaatagcctc tacaattgca aaaggtataa
    60181 aggctagaaa agaaaagggt ttaacaagta atctaaatat aatagcctgt gaaaatgcaa
    60241 tatacgcaag ttcttcttta aaagaagagg tacttaagta tttaaataag gaagaagtag
    60301 aatatttaga gatatatgtt ggttttccaa actgttcagt tgatagaata gttcctcctg
    60361 gtaaaaatga aaatcctctt gatgtaacag ttgaaaattt ttatgagtgg aatgttgaaa
    60421 aacaaggatt taaaggggaa ataccaacta tagttggaat gaatttagct gacaacctta
    60481 tggcttatat agagcgtaaa ttgtttacac tgaatacagg tcatgctata acagcttata
    60541 taggatattt aaaaggatat aagactatag aagagagtat aaaagataaa tttatctgtg
    60601 atatagtcaa aagtgcaatg gtagaaagtg gagaaggatt gattaaaaaa tacaattttg
    60661 actcagaagc gcactataaa tatattgata aaattttaaa tagatttaaa aatccatatc
    60721 ttaatgatga tgtattaaga gttggaaggg aaccattaag aaaactaagt gataaagata
    60781 gattgattaa acctttaatg acagcaaaat catatggatt atcagttgac aatttgattc
    60841 ttggaatagg tgcagcgctt cattataata atagtgaaga tactcaaagt gtagaattac
    60901 aagagttgat aaagtctaat ggtgtaaaaa aagctgttgc taaaatagct aatataagca
    60961 atgacgaaga acttttaaat aatatcgaaa aaagttatat atttatgaaa aatttataaa
    61021 tttacttgaa aaaaagtagt tctgataaag taactataat atattattct acacagtttg
    61081 aattatttgt tgaataatag agaattataa tatataatta aaaggaataa attaatatat
    61141 ttacctgtat atgtttgata atatggttca aatgtttcta ctaagctacc attaatagct
    61201 tgactacagg agtgaagaag atatagttta tacttatttt aaattatata ttaagttaat
    61261 tactttgaat tttaagctcc tgtctatgat atagacagga gcttttttag tattttaata
    61321 taaaatactt acaagaatag atagcaaaat tagaacaaat ataatttttt tattaatata
    61381 actttagaaa gggctaggtg gaagttcaat gaaggcttta caagaaaaga tattgagaga
    61441 aggcagtgtt tcaggaaatg atatactaaa agttgatagt tttttaaacc atcaaattga
    61501 tgtagctttt ttaaatgaaa taggaagaga atttaaagag agatttaaag aagaaaaggt
    61561 ggataagata tttacaatag aggcttcagg aatagctata gcatcaattg tttcacagta
    61621 ttttgataat gcacctgtag tatttgcaaa aaaatcagaa tctaaaaatt tggataaaga
    61681 tgtatatgag actaatgtat attcatttac taaggcaaga gaatattcag ttaaagtttc
    61741 taaaaagtac ataaacaaag gtgaaaatat attgatagtg gatgattttt tggcaaatgg
    61801 aagagctgct cttggactta aagatttaat tgagcaagca gaagctaatt tagttggagt
    61861 aggaattgtc attgaaaaag gatttcaagc tggaggagca cttttaaagg ctaatgatgt
    61921 aagattagag tctttggcgg tagttgaatc tatagataat ggaactgtaa aatttaggta
    61981 atttatgata ttatatactt gtgtttagca catattttaa ctatgtaatt atggaggatt
    62041 ttttatgata ttttttatag acacagccaa tattgaagaa ataaaagaag caaatgattt
    62101 aggtgtaata tgtggtgtaa ctactaatcc atctctaata gctaaagaag gtagagattt
    62161 tatagaggta gttaaagaaa taagtgaaat agtagatgga ccaataagtg cagaagtaat
    62221 aagtttagag catgaaggta tgatagagga agcagaaaaa ttatctaaga tacataaaaa
    62281 tatagttata aagataccta tgacagcaga aggtctaaaa gcggtgaaag tactatcaag
    62341 taaaggtata aaaactaatg taacacttat attctctgct ggacaagctc ttttagctgc
    62401 tagagctgga gctacatatg taagtccttt tgttggtaga ttggatgata tatcacaaaa
    62461 tggtcttgat ttaattgaag aaatcgttga tatatttagt gtaaatagta ttgaggctca
    62521 aataatagtt gctagtgtta gaaatccaat acatgtttta caagctgcta gaatgggagc
    62581 agatatagca acagttcctc ttaaagttat aaaccaaatg attaagcatc ctttgacaga
    62641 caaaggaata gatagcttta tgaaggattg ggaaggtgct tctttaaaat tataattata
    62701 aactacgctt tataagtata ttaaagaggt tattatggaa attctaagta ataaggctag
    62761 gctattttgc ctagtcttat tttggtgtat aatatattga aacatattat tgaaatagat
    62821 taatttttta agtgaggagg cgaaaaatgg ataaaatatt aagagagata caaagagaag
    62881 ataaaaaaaa tccatatact gaccaagaac ttgctgaaat gttaaatgta gctaggtctg
    62941 aagtgatatc agtgaggaaa aaaaataata ttttagattc gagagaaaga agaaaaaaaa
    63001 tattaataaa agatatatca aaaattgtaa gtgaaaatcc tcaaatgtct gaaagaaaaa
    63061 taactgagat attaatagag aatggatata atatatcgag aagtgcagtt tcaaaattat
    63121 taaaagaaga aaatttaaat cagtcaaaga ttgggattaa agataaagag ccagcatcat
    63181 caggaaagta tgtgaaggtg agtaaagttg tagaagaaga tggatttgaa gaattgatag
    63241 gtataaaggg aagtttgaaa gaaaaggtaa atctagctaa gtcagcaata atgtatcctc
    63301 ctaatggcct tcatactata atatatggag aaacaggggt aggtaaaagt gaattagcta
    63361 catgtatgta taaatatgct ataaaaaaca acatcaaaga agagaacagc ccatttatag
    63421 tgtttaactg tgcagactat gcagaaaatc ctaatctatt gatagctcaa ctctttgggg
    63481 tagtaaaagg tgcatataca ggagctgatg caaatagaga aggtcttgta gaacaagcta
    63541 ataatggaat attgttttta gatgaaattc atagattgcc tgctgctggg caagaaatct
    63601 tattttcatt aatagataga ggagaattta gaaggttagg agaaagtagt tctaatagaa
    63661 aggcaaatgt tctcataata agtgctacaa cagaaaaccc agattctaat ttacttcaaa
    63721 catttagaag acgtatacca atggtaataa atttacctaa tatgagtgaa agaccaaaat
    63781 ctgaaagata tgaaataata ataaagtttt ttgaaagaga agcaaagcga gtaaacaaga
    63841 attttataat aactaaagaa gttatgtgtg cacttatgaa ttataagtgt actggaaata
    63901 taggtcagtt aaagagtgat atacaagtaa cttgtgctag agcttttagt aaatcaatat
    63961 tttctagcga taaggtaatt atagatttag atagtttaag ggattatata aaaagtggat
    64021 attatgattg taattgtaaa aatgaaaagt attctgagtt ttcagttgag gatatatata
    64081 tagatatcag tgaattggtg agtggaaaaa atagaatgtt atctgataat gagataagcg
    64141 agatatataa ttatgcagaa aaagagctta aggttttgga aagtaagtgt ttttcagaag
    64201 aagagttaaa aaatgcattt atagaaaagt tagataagaa gtttaatgct attaaaaaca
    64261 ataaaaattt atctgataga agaagtcgaa tagactgggg aggacaatta aaagagtcta
    64321 cattggagat aatggataag gtaattgtat ttattaagga gcagtttaag catgtaaatc
    64381 aaggattgta cttggctcta gcaattcaca ttgagcatgc tataggtagg ataaaagatg
    64441 gaaaaactat aataaatccg agtttagata aaataaaagc atcaatgcca atggaatatg
    64501 aattgtcaag atatataatg ggtatagtgg aagatttgac acaagtaaca tttccagaag
    64561 atgaacttgg atatttggct tattatataa ataaattttg ttataatgag gaaagtataa
    64621 aagataaagt taaagtagta atagttacgc atggtaaagt tggaattgaa atgtctaaag
    64681 ttgtaaatca tattttaggt atagaatgta cactaggtat agaaatagca cttacagatt
    64741 caccatcaga ggggatagag catgtattag aagagcttca aaagatagaa gctagaaaag
    64801 gtattctagt tctaattgat atgggttctt tggtaattct tggtgatgag gttgaaaaaa
    64861 gacttggaat tagatgtaaa actgtaaaca gagtagatac gttattggca atggaagcag
    64921 gaaaacttgc aaccattgaa ggaaaaagtt tagatggtat aatagcagat ttaaagaaaa
    64981 ataagaatta tgccatgata aatacaaata aatttagtta cagaaaaaac gagtatggaa
    65041 agaaaaatgt aatcattact ttatgtttga gtggtgtagg tacagcttta aatttaaaag
    65101 agcatataga aaaacaaatt aaggaatatg acactttaat tgaggtaaag ccagttgctt
    65161 ttttaaataa taatttagaa gaagagttaa atgatattga agctgaatat aatattattg
    65221 ctatctgtgg aactatcgat atagattata aaaacgtacc ttttatttct tataatgagg
    65281 tacttggtaa aaatggtatt aataaagtat tagagcattt aaacagtaaa caaccagttt
    65341 taaatattga aaaccagttg aataatttaa tacatgaaga tttgatttta tacaattttg
    65401 aaggaatttc aaaggagtat ataattgata ctcttgtttc aaagcttgaa gaaggtggat
    65461 atgttgactc aaagtatata ttaagtgtat ataaaagaga agcaatggga agtgttgtaa
    65521 tggcctctaa ggtagccgtg ccacatggac ttccagaaaa cgttataaag cctgcaatag
    65581 caatcgcaag gttgaataag cctatagtgt gggacaataa atttatggtg gatttggtag
    65641 tactactggc acttaaagaa aataataaga aagaaatacg aagcttattt tcaaagatta
    65701 atgaccaaca tactttagaa gttttattaa atactgaaga taaaaatgaa ataaaagaac
    65761 ttttaagcta attattagta cagagaagaa agacaaaaaa tttgctttag tataaaattt
    65821 aaaactactt aattgctaag tagttaatta ctcgatataa ggctagttct atgaaattta
    65881 tttatatgat tttatagaat tagctttttt cttggtaaat aaaatatatg aatttattta
    65941 tgcaaaaagt aaattttatt ggacaattct atgagaattt ttcctatatt tcttataaaa
    66001 tatagaatat ataaaaataa attaaattca taataaataa ttttataaaa tagttgttaa
    66061 acataaaaaa ccatttgtaa aaaacaaaaa aatcatttct ctaacaaaaa aaaccacaaa
    66121 aaatataaaa aagtatggct agttaagtga ttaacaagta aaaattaaaa taaaaatcaa
    66181 aaaaaattta tcaatgaaag tcagctaaaa tcctggaaga gagcattatt tttgggaaaa
    66241 cattttcttt tgtttcacaa aaaaagccac tttttggcac acaacatgct ttatataaag
    66301 tcaagaaaaa ctaaggtata agacaaaggc aattaggagg tgtaaatatg gagtttataa
    66361 attttgtaag tgataaagtt atagacctta aaatggattg taaaacgaaa gaagatttct
    66421 ttaaagaaat acataataaa gtttttgatt taggctttgt aaaagaagaa tttggagaaa
    66481 aaatattagc aagagaaaat gtatttccaa caggtttaaa tttaggagat tatggagtag
    66541 caataccaca tacagatgca gaatatatta aagagcaatt tatatcagtc tgtactttta
    66601 atgaaccagt agtgtttagt tctatggaag accaagatga aaaagtacct gtaaatttgg
    66661 ctttcgtatt aggacttaat caaccacaca gtcaattatc tgtattaaca gaattaatgg
    66721 gaattatgca aaataaagag ttagttgata agttgatgag ttctactgat aaagaagaag
    66781 ttttaaagac actaaagtct ttataaaaat aaaaaagtac taaaaataaa aaatataaaa
    66841 ataaaaatta ttaggaggaa ataaaaatga aaaaaatatt agtagcatgt ggagcaggaa
    66901 tagcaacatc aacagtagtt tgtgacaagg tagagagatt agttaaggaa aataatatac
    66961 aagcagaagt tatacaatgc aaaatagctg aatgtgcaac aaagcaagaa ggagcagatt
    67021 taatagtatc aacaactata ctaccaacaa cttataatat accagcaata aaagcaacag
    67081 catatataac tggagtaaat acagcagcat tagataaaaa aatattagat gctttaaaat
    67141 aatcctatca tagatacatt gaaataatat tttataaaac agaaaaagga ggatttataa
    67201 atggataaat tattagcagt agtacaatac attttaaata tgggaccgac agtaatacta
    67261 ccaataacaa ttgtagtact aggaatgata tttagaatta agtttacaaa agctttaaag
    67321 tcaggtctta caattggtat aggatttgtg ggtataaact tagttgtaaa cctattaaca
    67381 tcaacactag ggccagcggc tcaaggaatg gttgaaagat tcggacttaa tttaacagta
    67441 atagatgttg gttggccaac aacagcatca gcaacatggg cttcaccagt tgcaccaata
    67501 ttaataccag tttgtttatt agtaaactta ctattattat acttcaataa aacaaagata
    67561 ttaaacgttg atatatggaa ttattggcac tttatagtag caggtgcagt tggatatata
    67621 gtaacaggaa gttatgtttg ggctatattc tgtgcaatac taatggagtt attagtactg
    67681 tttattgcag aaaagacagc aaaaaatgtt caggagtttt atgatttaga aggtatagca
    67741 ttaccaactg gttcaacagc ttcatttgct ccacttggat atttagtagg taaatttgtt
    67801 gaaaaaatac caggaataaa taaaatacaa gcagacccag actctataca aaaaagattt
    67861 ggtatatttg gagaaccaat gatgatgggg attatactag gtataatact tggagcactt
    67921 gcgggatatg atgtagcagg aatattcaat gtaggtatat caatgggtgc agtaatgtta
    67981 cttatgccta gaatggttag aatattaatg gaaggtttaa ttccaatttc agaatcaata
    68041 agagatttct tacaagcaaa atatggagac agagaacttt atataggtct ggatgcagca
    68101 gtagcaactg gacatccagc agttatatca acagctctta tacttgttcc tataactttg
    68161 ttcttagcag ttatactacc aggaaacaaa gttttaccat ttggagactt agcgacaata
    68221 ccattttata tggcatttat agtgtgtttt agaaaaggta atatagttca atcagttata
    68281 acaggaacaa tagtaatagc tatatcactt tatatggcta caaactttgc agatgttcat
    68341 acacaattat tacaacaagc aaatatgatg ccagaaggaa caacaatggt tacaagtata
    68401 gatacaggtg gaaacttgct aaaatgggga atattgaaat tatctcaatt agtttcttca
    68461 tttggaatat tctagtatgt agttaataga gattactctt ttttagtaaa gtatgcgaaa
    68521 atttaacatt tagcagctac taaaaaagag taatattttt tataaatttt taaaaataca
    68581 aaatacaaga ggaggagatt tatcgtgaaa gcagcagtat tacatggcac aaatgatatg
    68641 agatttgaag atatagaaat aaaaccatgt gaaagtgatg aagtaaaaat aaaagttatg
    68701 gcagcaggaa tatgtgggtc agatcctcca agagtattaa aacattggaa atatccagtt
    68761 ccagctatac caggacatga gttttctgga gtaattgctg aagttggtaa ggatgtaaaa
    68821 aatgtaaaag ttggagatag agtagttgca attcctttta taccttgtaa tgaatgtgaa
    68881 tattgtaaaa gaggattatt ttcattgtgt gatgaccatg gaatgttagg agctaaaagt
    68941 tttggagctt ttgcagagta tgtaaatata aaagctacaa atgtacttcc aataggagat
    69001 atgaactttg aagatgctgc aatgatagag ccactagcag ttgctatgca tggagtactt
    69061 aatataggtg ttcaagttgg agacactgta gctgtaatgg gtagtggaac aatggggcag
    69121 ttggtaatac aaggacttaa aatagcaggg gcaggaacaa ttatagcagt tgatatatct
    69181 gataataaat taagagaatc aaaggaatta ggggctgata taataattaa tgctaaagat
    69241 attaacccag tagaaaaaat aaaagaactt actggtggaa aaggtgttga catagctctt
    69301 gaatgtgcag gttcaaaaat aactcaagaa caatgtttac ttataactaa aaagaaaagt
    69361 aagataggat ttttagggat agcatattca gatataactt tatcagaaga agcatttgaa
    69421 aatatattta gaaaagaact agaattaaaa ggtttttgga actcttattc tgcaccattt
    69481 ccaggacaag aatggactaa gggaatcaat ctagttaatg aaggaaagat aaaattaaaa
    69541 gaaatggtat ctcatagatt ctcacttgaa gatacttaca aagcatttga aatgataaga
    69601 gatagaaaag aagaatttaa caaaatatta attttaccac aaggggttga aaaataatga
    69661 aagcagtagt taaaactaaa ccaggctatg ataatgtaga agttttagaa gtagaagaac
    69721 caaaagctac aggagacaag gttaaaataa aagtagaata tagtggtata tgtggttcag
    69781 atatacattc atttaaaggt gaatatgcaa atataaaagc cccagtaaca ttaggtcatg
    69841 aattttctgg aattgttgta gaagtaggag aagatgttaa aaatataaaa gtaggggata
    69901 gagttacatc agagactact tttgcaactt gtgagaaatg tatatattgt gaaactaaag
    69961 attataactt atgcccaact agaaaaggta ttggtactca agtaaatgga agttttgctg
    70021 agtatgtatt atcaagagaa gaaagcatac atgtacttcc tgaaaatgta tctttattat
    70081 cagcagccct tacagagcca ctagcttgtt gtgttcatgc agctcttgaa aagactacta
    70141 tagaaagttc tgatacagtt ttaataatag gaccaggacc aattggttta ttattagctc
    70201 aagttgttaa atctcaaggt gctacagtta taatgtctgg tgttacaaaa gataaggaaa
    70261 gattagaaat agctaaaaat cttggagtag atagaactgt aaatgtaatg gaagaaagtt
    70321 tggcagatgt agtgaatgaa atgactgatg gaaatggagt aaacaaagga tttgattgtt
    70381 ctgggtttat gccagcagtt aacgaagcct taagactgct tagaaaaaaa ggtactttcg
    70441 tacaagttgg aatctttgct aaaaaattaa atgaaatgga ccaagaagca ataatccaaa
    70501 gagagttaca atatatagga agcaggtctc aaaagccaag ttcttggatt acagcattag
    70561 atttaatggc aaatgggaaa gtaaatacag aagctttagt tactagaact gttggtttag
    70621 acgaatttaa agaaggtatt acagctttaa tgaacgggga agaaataaaa gtagcagtaa
    70681 aatcttaaaa aaacatttgt attattttaa aaaaaattgt aaaatctact gtaggataaa
    70741 aaaatgtaag gtcttaaaaa ataacaggag gaagaaagta tgagcactct tagagatcat
    70801 tctaataata ttagaaaaaa cataataaaa atggttgcag aagctaaaag cggacatcca
    70861 ggtggttcat tatcaatagc tgatatgttg acagtattat attttgataa gatgaacgta
    70921 tgtgcagaaa atccaaaaat ggctgataga gatagatttg ttctatcaaa aggtcatgca
    70981 gcaccagctt tatatgctac attagcagaa aaaggatttt tcccagaaga agaattaata
    71041 acactaagaa aatttggttc taagttacaa ggtcacccag acatgaaaaa agtagcagga
    71101 atcgatatgt ctactggttc tcttggtcaa gggctatctg cagcaaatgg tatggcactt
    71161 gcaggaaaat tagataacaa agactataca gtatatacta tattaggtga tggagaaatc
    71221 caagaaggtc aaatatggga agctgcaatg acagcatcac attacaaatt agataattta
    71281 attgcatttg ttgacttaaa tggattacaa atagatggtt ctaatgaaga agtaatgaat
    71341 gtaagtccag tagatgacaa attcaaatct tttggatgga atgtaatagt aataaatgga
    71401 cattcttttg aagaaatagg aaatgcagtt gatgaagcta aaaaagttac aggaaaacca
    71461 actgtaataa tagctaaaac agtaaaaggt aaaggtgttt catttatgga aaataatgct
    71521 gcatggcatg gaacagctcc aaatgcagaa caagcagagc aagcattgaa agatttagaa
    71581 ggaggtctat aggaatggga atagcaacta gagaagctta cggacaagtg ttaaaagaac
    71641 ttgcagaaaa taaagatata gtagtattag atgcagattt aggaaaagct acaaaaagta
    71701 tatcatttaa agaagttgcc ccagatagat tttttgacat ggggatagca gaaggtgaca
    71761 tgattggtac agcagcaggt cttgctactt gtggaaaaat accttttgcg agtacttttg
    71821 caatatttgc agcaggaaga ggctatgagc aaataagaaa ctctgtagca tatccaaatt
    71881 taaatgtaaa aatagcagct actcatgcag gtgtaacagt aggtgaagat ggtggtagcc
    71941 atcaagctat agaggatata tctctaatga gaggtatacc aaatatggtt gtattaaatc
    72001 cagcagatgc tttagaagca agacaagcta ttcttacatc tattgattat aatggacctg
    72061 tttatataag attaggtaga gctgcaactc ctgatgtaaa cagtgaaaat tataaatttg
    72121 aaataggaaa aggaactgtt ttaagagaag gttctgacat aacagtaata gctacaggaa
    72181 taatggtagc aaaagcctta gaagcagcag aagaacttgc taaagaaggt ataaatgtag
    72241 aagttgttaa tatatctaca ataaaaccat tagatgaagc attaataaaa gaaactgcta
    72301 agaaaactgg aaaagtagtt acagcagagg agcacagtat aataggtggt ttaggttcag
    72361 ctgtatgtga agctttagca gaaactaaag atgtagtagt tagaagaatt ggtgttaaag
    72421 atgtatttgg tcaatcaggt acaccagctg atttattaaa acactatggt ttaactacag
    72481 aagatatagt aaaaaatata aaagagttgt tatagatata aatatatcta aataacaaat
    72541 tgatttgaca taagtcaatt aaagctgtct taaaaataga aagaaatttc tacaatggga
    72601 cagctttatt tttacaatac tttattttta tgataattat aaaatagtct gaaagtaatc
    72661 aaaaaaatta taaaaagagg tgctatttaa tgaaaatatc tattggatgt gaccatggtg
    72721 gttatgaatt aaaggaatat ataaaggaaa atttaataaa taaaggtata gaagttgaag
    72781 atgtgggtac aaattcaaaa gaaagtgtag attttccaat atatgcaaaa aaggtaagtc
    72841 aaaatgttca aagtaaaaaa tctgatttag gcatactttg ttgtggaaca ggaataggta
    72901 tgtctattgc agcaaataag tttaaaggaa tcagagcagc tgttgtttct gactgttttt
    72961 cagctaaggc aactagagaa cacaataata caaatgtact ttgtttagga gaaagagtta
    73021 ttgggaaagg attagcaatg agaattgttg aagaatggtt aaattcaagt tataatggag
    73081 aaagacatgc aagaagatta caaatgattg atgatataga aaaagaaaat ttataaatat
    73141 ataatttaca acaaggggga gcgttatgtc tattatttgt gcttcaataa tgtgtgcaga
    73201 ccaaatgaag ttaaaagagg aattagaagc tcttgaagaa gcaggtgtaa aattacttca
    73261 ttgtgatgtt atggatggaa tatttgttaa aaacttggct atgggaccag agttattaaa
    73321 atcaataagt gaaaatacaa caataccttt agacatacac ttagccacag aaactccaga
    73381 taaatatatt gatatgatgt cttatataaa gccaaaatat atttcttttc atgtagaatc
    73441 aagtacaaat gtaaaagctg atatacaaaa gttaagaaat tatggtatag ggccagtgtt
    73501 agcaataagc cctcaaacaa gtgtggataa aatagaagaa tatataagtt tagttgaggg
    73561 tatcttagta atgacagtaa atccagggtt tgcaggtcaa aagtttaatc tttctgtatt
    73621 ggataagttg gataaactta cagagatact aaaagattat gataatcctc catttataga
    73681 ggttgatgga aatataaata aggatactat taaacttatg aatggtaaaa aagtagatat
    73741 atatgttgtt ggtacttcag ctttatttaa tgataagcct ccaatttcat ataaagataa
    73801 aatagaagaa ctaaaagaaa gtataaagta accatgtaat aaaattataa tatgtttctg
    73861 tttaatagta aaaatttagg tggaaacaag aaattttata atatttaata aaaattttgg
    73921 ttgagtaagg agaatttttt atgggagacc tatataaact acaaaatggt actgatatta
    73981 gaggaatagc gtatgaaaat gattctaaag aagttaacct aactgtagaa gaagtaaaaa
    74041 aaatagctaa agcgtttcat atttggttaa aagaaaagac taagaaagat aaagtaactg
    74101 ttgccatagg aactgattct aggataacag gaagccaatt tagaagtact gttattgaaa
    74161 ctttaactaa tgatgattgt aatgtaattg attgtgagat tgccacaact ccagctatgt
    74221 ttatgacaac tattatggat ggatacaatt ctgatggggc gattatgatt acagcaagtc
    74281 acttacctta ttactataat ggtttaaagt ttttcacaga aagtggaggt ttagaaaaaa
    74341 ctgatataaa agagatgttg gatatagctg ttaaaaatga tagtgtagac tatgaggaag
    74401 taaataaaaa aggtgaagtt atagtaaaaa atttaataga agattattct aatttattga
    74461 tagataaaat tagaaaaggt gtaaattcaa gtaaaaatta tgaaaagcct ttttctgggc
    74521 ttaagatatt ggttgatgca ggaaatgggg ctggtggatt ctttgctgaa aaagttttac
    74581 acatactggg agcagatacg acaggtagtc agtttttgaa cccagatggt atgttcccaa
    74641 atcatatacc taatcccgaa aacaaagaag caatggaaag catatgtaaa gctgtgttgg
    74701 ataataagag cgacctagga ataatctttg atacagatgt agacagagct gctattgtag
    74761 gtaaaaatgg caaaccaata aataaaaatg ctcttatagc tgttatatca tcaatagtat
    74821 tagaagaaca tccaaaaaca gctatagtaa cagattcgat tacttctgaa ggacttgcta
    74881 aatttataaa tgaattacaa ggaagacatc atagatttaa aagaggatat aaaaatgtaa
    74941 taaatgaagc tataagatta aatagtgaag gtgaagagtg ccatttagct atagaaacgt
    75001 ctggacatgc tgctttaaaa gaaaattatt tcttagatga tggggcatat ttaatagcta
    75061 aaattttaat aaaagtagca aagctatcct tggaaggaaa gactatagaa gaattgatag
    75121 aaaaccttga agaagctcaa gaagagaaag aagttagaat aggcattaat aaagaagatt
    75181 ttagaacata tgcagaggat atattaaaag atttagattc tcatgttaag agtattgatg
    75241 gatggtctgt agcaccaaat aattttgaag gcataagagt taattgtgat gaatcaaatg
    75301 gagatggatg gtttttactt agaatatcac tacatgaacc attattagct ttaaatattg
    75361 aatcaaataa aattggcgga gcagaacaaa tttattctaa gttaaaactt ttcttagaaa
    75421 aatatgattt aaaaggtctt tagggtaaat agaaagaata tatttatatt gaagaataaa
    75481 tgtaaatttg tacctaagat tacaaatatt acaaaattgt aatcttaggt aacagagatg
    75541 taactgatta tggaaacact atgtgatatt atagatacag agagatgaaa tatgtgatga
    75601 attatagaga aatataattt aaaatgtatt aatatcacac caaaaaggta taatcaaaaa
    75661 atatgtaaat ataaacccca acatttagaa aaagacctct aaggaggttt ttttcttgtt
    75721 taaataactt aaaatatatt tttatattaa tatatcaatt aacttttcta aaagtaagca
    75781 ttaccttaaa taaatcagca tctataatta tttccatgtg tgcattttct aattcaatta
    75841 tattttgagc aattgataaa ccaagaccag agccatctgt ttttctagat atatcacccc
    75901 ttctaaatct ttctattaac tcttctggtt ttagatttag tttatcattt gaaatatttt
    75961 taaacgttaa tattatattt tcttccttta taaacatatc tatatagacc ctagtgttag
    76021 gcatagagta ttttagtata ttgcaaatta gattctcaaa aactctccaa gtttttttac
    76081 catctatcat ggtaaaaaca gcatattcag gtgtttctat tataaaatct aaactgctat
    76141 tttgaatttt gtcttcaaat tctacaatac tttgaattaa aagttctctt atatcggttt
    76201 ttgttatatt aaattctaca tctccactac ttagcttaga tgcttcaaat atgtcatcta
    76261 ttaataattt taatctttgt gattttttat ctaaaatatt tatatagtca tttatagtct
    76321 ctctgtcaaa gtcattattt tttaacatat caacatagct taatatagat gtaagtggag
    76381 tttttaagtc atgagatacg tttgtgataa gctctgcctt catcctttca ttttttatat
    76441 tagcatctac agcagtttca agaccgcctg ttatattatt tatacttttg gctaaagtag
    76501 atatttcatc atctcctata acttctaatt tatactttaa attgccattt tctatatttt
    76561 ttatattttt tgatatgtta tttatgtaat taaacttaac agataaaaag ttgtatatat
    76621 aaaaatgaaa aactgtgttt acaagtgtaa ataaaattac tatagctatt gcctcagcat
    76681 aatatatata cataaagaat atcaaaacaa gatattggat aatagcttgt acaactatag
    76741 atattaaaaa tactatagct aattttttat ttatagtttt tttattatac atactaagta
    76801 agtttgaaaa gaatacatat gttatagaca tatcttttag attatagtta ttatatttaa
    76861 tattttcata tattatatag actatagata taattataaa attgtagatt attaaattag
    76921 tgttgtaaaa cattttatta cttgtaaatg catgaaacct taaggttaat agtatcaaag
    76981 ttaatataag tgtaagttct atttttacct tagaaaaaag gtttatgaca ttctctaaga
    77041 atttgacttt agtttgttta ttttttttat acaatgtaaa acatagtata gtcaataaaa
    77101 aacttgataa tataatacct atgcagacaa actctaattc tacttttgac aaatgtacag
    77161 gagtaccgaa aaaataaaaa taagggagag caaactctct ataataataa ttaatattag
    77221 aaaagttatt attcaaatca taaactgctt caaataatat agaaactaat agaaacagta
    77281 ataataataa aataaatttt gctttagaat cattaataat taagtttttc aattttgtaa
    77341 ccaatgcccc acaccacctt taaatatttt ggttcttttg gattaatttc aatcttttct
    77401 ctaattcttc taatatgaac agcaatagtt ctctcacaac tataagcatc ctcattccag
    77461 acattttcat aaatctcatg agaagagaaa attttacctt ttcgtgacat aagaagtgta
    77521 agtattttat attcaagtgg tgtcatttta atttcctcac catctaaaga aactattttt
    77581 gtatctgtat ttagctctag gccaccactt tttagaatat aattagtatc atttgagtta
    77641 tttgtattac taaaatcacc taaatttata taccttctaa gttgagattt tactcgagca
    77701 gtaagttcta gtggattaaa tggtttagtt atatagtcat cagcacccat attaagacct
    77761 ataattttgt ccatatcttc tgattttgca gataagagaa ttattggtat attccttttt
    77821 tctcttattt taagtgtagt tttaagccca tctaaattgg gcatcattac atccattatt
    77881 attaatttaa tatcattttc gattagtatg tccaatgctt caagtccatc atatgccttt
    77941 aaaacattaa agttatcagg tctcaaatag aactctatag catcaactat ctctctatca
    78001 tcatctacaa ccaatatatt ttgattcaat ttattaaccc ccttgaaatt ttatttttaa
    78061 ccaattttta ttttatacca aaaagaggta ttagaaaaca gtaagcccgt tcattatgaa
    78121 ataaaaacta gtacttttaa tatattgtca atgcatatag taaatttaaa agtatagacg
    78181 cccatattaa tctgaaggta aaagtttatg aaaat
//
LOCUS       DAEPID010000010        74783 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.010, whole genome shotgun sequence.
ACCESSION   DAEPID010000010 DAEPID010000000
VERSION     DAEPID010000010.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 74783)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 74783)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..74783
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.010"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            complement(138..1229)
                     /locus_tag="KR257_000758"
     CDS             complement(138..1229)
                     /locus_tag="KR257_000758"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902002.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Rpn family recombination-promoting
                     nuclease/putative transposase"
                     /protein_id="HBH0029485.1"
                     /translation="MIEKVEEKSKIIKTSKEYKRTIIEEKDKEWTKKLNDILSRSSFS
                     NDELDKIKALIPKEILTNENVGEVVTEDGYAKPEYDEVFKSLFTLNNEYDLLVNFIND
                     ILKDAPYANRNIKPFTQIKRIIRVETDPTINYIGEKRPKLDILAEDEENNHINIEMQR
                     AFENDYLERAEYYLSRVHGRKLEEGKEYKEIGKTIGIHILNHVKYNHIEDYVNCLRLT
                     MDGHPDIYSSKTALYFIELPKIHKSDYIVNRIMLWGKLISNPSNLDVRVIAKNDSIIK
                     KALDRLKELGSNEEYLLNLKRGAYIMNKSRNFKEEIERETAIRVAKEKDYKIIIMLKK
                     NGFKLDDILNKFNDFDLSEDEIKEVYENN"
     gene            complement(1997..3916)
                     /gene="thrS"
                     /locus_tag="KR257_000759"
     CDS             complement(1997..3916)
                     /gene="thrS"
                     /locus_tag="KR257_000759"
                     /EC_number="6.1.1.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009904969.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="threonine--tRNA ligase"
                     /protein_id="HBH0029486.1"
                     /translation="MIKVALKDGSIKEFENAISVMDVAKSISEGLARNVVAASVNGEV
                     VGLDHIIDTDCDLNLFKFEDKEGKEVFRHTSAHILAQAIKRLYPEAKLAIGPSIENGF
                     YYDIDLDHRLVPEDLEKIEAEMKKIAKEDLKIERFELPRNEALELMKEQGEDYKVELI
                     SDLPESEIISFYKQGDFTDLCRGPHLPSTKKVKAVKLQSVAGAYWRGDENNKMLQRIY
                     GTSFEKNKDLEEYLHLLEEAKKRDHRKLGKELGLFMIPEEGPGFPMFLPKGMELKNEL
                     LKFWREIHRKAGYIEIESPIILNRKLWETSGHWYHYKENMYTVKIDDEDYAIKPMNCP
                     GGLIYYNSQLHSYRDFPMRVAELGRVHRHELSGALQGLMRVRAFTQDDSHIFMLPEQI
                     KDEIKGVANLIDGIYKTFGFEYNLELSTRPENSMGSDEEWEAAENGLREALEELGLPY
                     TINEGDGAFYGPKIDFHLKDCLGRTWQCGTIQLDMQLPRQFDNTYIGQDGEKHRPVMI
                     HRVAFGSIERFIGILIEHYAGKFPVWLSPTQVKILPISDKFMDYANEVKKELFDKGIR
                     VELDDRAEKIGFKIREAQLEKVPYMLIVGEKEVADNNVSVRSRDKGEIGSIKLDEFIA
                     SISKEIESRESIIQD"
     misc_binding    complement(3980..4217)
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00230"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="T-box leader; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /bound_moiety="tRNA"
                     /db_xref="RFAM:RF00230"
     gene            complement(4676..5278)
                     /locus_tag="KR257_000760"
     CDS             complement(4676..5278)
                     /locus_tag="KR257_000760"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429652.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF445 family protein"
                     /protein_id="HBH0029487.1"
                     /translation="MDNLIRILILAVIGGFIGYVTNVVAIRLIFRPIEPIKIPILNIE
                     IVGLIPKRRAEIAANVGEIIQEEFLSMDEILANIITDEDKEEVVRYIKARVKIIIHEK
                     VSFIPSGIKNMIQDYLGEIIESEVKQSIDELSKNIINKANERIDIQKMVEDKINELDL
                     YELEEIIIRIAKKELKHIEFLGLVLGFLIGIAQGLITMFI"
     gene            complement(5458..6276)
                     /locus_tag="KR257_000761"
     CDS             complement(5458..6276)
                     /locus_tag="KR257_000761"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003417993.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="putative sporulation protein YtxC"
                     /protein_id="HBH0029488.1"
                     /translation="MVEKDNISSMKFLRNNNVNDRLIYTNDIVEVVIDSAKQEVLNKK
                     ILNGTKAEQRALNIDEISTEITSMIISIMKEKLLKEYILKCYGRTYPEDKNNIYIYSL
                     NIFAKKEIFMRETVFTRVRNYIEENDFINVEGFIRFRMREFMKYISAIGDIAVEEYLI
                     KKDQDEFIRVLKYFIDTQEEKIDLLKVHIMEDNTFVLYDKNGNKIDSIDDEEIINMVI
                     RENLNYEDFLISTLLTLCPKKIEILDLLNNNCSKEIIDTVEAIFENKVSIIMEN"
     gene            complement(6279..7040)
                     /locus_tag="KR257_000762"
     CDS             complement(6279..7040)
                     /locus_tag="KR257_000762"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003417991.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0029489.1"
                     /translation="MEFTREPFILDDDLCLALVDKRISYLMENELKLRNIEIIKTIEC
                     KELYESIKYHPDICICNLGKGDIIVAPNVYNQYKELLSRYKFNIIKGEANLLNRYPYD
                     IPYNIAIVGDYAIHNFKYTDKAILDYIENNKLKKINIEQGYSKCSICIVDRTSIITSD
                     KGIWKSMKNTEIECLLIEKGHINLFEMNYGFIGGCTGLISKDKLAFCGDVKKHPDYER
                     IKSFVESKNKEIVTLSCENLLDIGSIVPLMTRKER"
     gene            complement(7530..8642)
                     /locus_tag="KR257_000763"
     CDS             complement(7530..8642)
                     /locus_tag="KR257_000763"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860859.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="BMP family ABC transporter substrate-binding
                     protein"
                     /protein_id="HBH0029490.1"
                     /translation="MKIKRILMACFVVVFTIFILAICNFDFGFDKVNKNNSNIDSAKS
                     KQSESKSLPTSAEKDKSNSKSKNKEDDTEDDSYVRKTIGVLLDTENLNNESYNNNVLS
                     ALKRADEDFDVRIKLEKPKTSKSFKESIEKLHKYEPDLIIAVGARFAEPIKEAATEYP
                     KQQFAIVDYTYKVQPANVISVSFQDNVTGYLAGLIAGKMTDTGKVGFIGGVEGSSRDK
                     YESGFRKGLKTSNKDAELLVKYSNIFENPESARTIAKEMRDSDRDVVFSATEDDSKRA
                     IQVARENGGKVIAINKDQYDMAPDNVISSIIKDVEQPVYELIKNVAKDGFKGSKVMEF
                     KIKDGELGLTSKSSRNIPPDVLEYIKKEYNKVKDTY"
     gene            complement(8768..9772)
                     /locus_tag="KR257_000764"
     CDS             complement(8768..9772)
                     /locus_tag="KR257_000764"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860858.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="BMP family ABC transporter substrate-binding
                     protein"
                     /protein_id="HBH0029491.1"
                     /translation="MRFKRILILMLTVAMIAGMLVGCANNPSNNPSSSKDNKSDISDK
                     SNSKKSVSMILDIEGTNNEAMNNSALLALNNAQKKLNIDTNKVESDDSSTFSNSIDIL
                     CNDNYDLIIAVGARFAKPLEMVAKKYPKQQFAIIDYEYDKQPSNITSISYEDNKSGYL
                     AGLIAGKMTESDKVGFIGGTKSSSRDKFESGFREGVKFSNSSIKDISVEYADVFKDSK
                     SVESIAKKMMDNGVDIIFSTTEDDSKAVIDAVRAKNKKVIATNKDQHELAPENVISSI
                     VKDFENPTYNLIQSFVKGNYKGGKVIENTVKSGSTGLAQNSSQNIPPDVLEYVNKNNK
                     "
     gene            complement(10077..10925)
                     /locus_tag="KR257_000765"
     CDS             complement(10077..10925)
                     /locus_tag="KR257_000765"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888355.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DegV family protein"
                     /protein_id="HBH0029492.1"
                     /translation="MKNLKIICDSLSDVPKDLLDKYDIDIVSLTVILEEREYKDRIDI
                     SGDEFYKKLREENVYPKTSQATYAQFKEIFEKYTNEDREILYIAGSATATGTYQSAVM
                     AKNDVDGKIYTYDSNLLCMGTGLLVIKAGELASEGKSVAEILPVLDELKEKAFVIFSV
                     DTLEYLQKGGRISSTKAAIGSILNIKPILEIRDGLVSQISQVRGKKNVISKMMELIKS
                     NCGDDLSDQIVYIGYSDDFKEKEQLSKVMQDELRPKEIRFFQIGVCIGAHAGPGVTGI
                     ICLKNK"
     gene            complement(10961..11431)
                     /gene="trmL"
                     /locus_tag="KR257_000766"
     CDS             complement(10961..11431)
                     /gene="trmL"
                     /locus_tag="KR257_000766"
                     /EC_number="2.1.1.207"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429657.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA
                     (uridine(34)/cytosine(34)/5-
                     carboxymethylaminomethyluridine(34)-2'-O)-
                     methyltransferase TrmL"
                     /protein_id="HBH0029493.1"
                     /translation="MSLNIVLVEPEIPQNTGNIIRTCAATGSTLHLVKPLGFSLDDKH
                     LKRCGLDYWDIADIQYYDSFEELQEKYPNSKYFFSTTKAKQSHSDVKYEENCFIVFGK
                     ETKGLPEPLLKANMDTCIRVPMLDVEKARSLNLSNSVAIVVYEALRQIGYPNMR"
     gene            complement(11625..12842)
                     /gene="nth"
                     /locus_tag="KR257_000767"
     CDS             complement(11625..12842)
                     /gene="nth"
                     /locus_tag="KR257_000767"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895583.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="endonuclease III"
                     /protein_id="HBH0029494.1"
                     /translation="MKNVNLKEINEKDVILEEEINKKGMDKKNIIEKEEINKKGIDKK
                     DIIEKEEINKKGIDKKDIIEKKEINKKGIDKKDIIEKKEINKKEMDKKDIIEKEEINK
                     KGMNKKDIIEKEEINEKEIDKMIGKKDEIIDEKDIENFMDIEEDKKSIKVSKKSTKKG
                     ETEKKTKKSSSNKATQKTSKETKSKFKIKNESANEKDVNKILDELEKLYPDAKCELNY
                     GTAFELLIATILSAQCTDVRVNKVTSELFKKYNTARDFANLSIEEISKEIKSCGIYKS
                     KSQKIKDTSEQLCELYDGEVPDSLEKLIKLPGVGRKTAGVVLSNAFNHPAIAVDTHVF
                     RVSNRIGIVDEPNPQKTEFALMEAIPKERWSHSHHVLIFHGRRMCKARNPECASCPIK
                     EDCNYYKELNETK"
     gene            complement(13040..15277)
                     /locus_tag="KR257_000768"
     CDS             complement(13040..15277)
                     /locus_tag="KR257_000768"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888352.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AAA family ATPase"
                     /protein_id="HBH0029495.1"
                     /translation="MKYNNTSEINPLDYILGQERAVEAMELGLKINNPAYNIYIAGEP
                     GTGKSTYALKVLNEYASKKNTHKDWCYIYNFENPREPIIVELEKGFGRELKKDMEKLI
                     ESLLEDFKNAFESENFEIEKNKLLDEYEIEKDMLLKQIKKYGEEKGFKLKQSKMGIVF
                     IPLKEEEDESDESDEEFYKAKRELENMAIQVVYKIRNLEEIAEKAVLELEEEIAKLVV
                     EPHIKRLCEKYENYDKIQTYLENIKKDIIEYMYLFYLDEEELKDKYDKEHFIKYKINL
                     FVDNGSSKNKESAPVVVEINPSPANLFGKAEYDYANGNIKTDFTKLLSGAFHRANGGY
                     LVLYADQLLKYTMSWEILKKTLQTKKVILETQTAIKPENMPLDVKLVLIGSHYIYDIL
                     YRYDEDFEKYFKVFVDFDSEMDKNEDNEEGIARFIAYQCDKNNLRHFTKSAVEEVIKF
                     STRLSGDLEKLSTKFNKIMEVVIEGSAYAEFRNSEYTKQCDVKKAISEKRKRINRVET
                     HMDESIENGFTLIETEGRKVGVINGLSVLSTGEYSFGRASRITATTSPGSKGIVNIER
                     EVNMSGSIHNKGVLILGGYLSENFAQDLLLSLNAYVCFEQNYGGIDGDSASSAELYVL
                     LSSLSGVSIKQNIAVTGSINQKGDIQVVGGISEKIEGFYSICKTKGLNGEQGVIIPRK
                     NQRNLVLSDEVNDAVRDGKFKIYTVERVEEAIEILTDVKFEEIKKLVKEKLISFSKIQ
                     TVSKE"
     gene            complement(15383..16297)
                     /gene="queG"
                     /locus_tag="KR257_000769"
     CDS             complement(15383..16297)
                     /gene="queG"
                     /locus_tag="KR257_000769"
                     /EC_number="1.17.99.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888351.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA epoxyqueuosine(34) reductase QueG"
                     /protein_id="HBH0029496.1"
                     /translation="MDNKELKAFCNLIGLNCVGVAGVDKYDNLEKILKNRQQKGYLTG
                     MEEPIIESRINPRHIMKDANSIIVCAFPYHINRQEKNKNSNLSKYCHGKDYHIVVKDF
                     LQQICDYISKTVTDFKYKLFADNGPLVDRYLAYLSGIGYFGINNNIITDEYGSYVFIG
                     YIVNNYKFEEDKPLEKSCFKCGKCVKYCPGNAILGNYDMNPKKCLSYITQKKGDLSEK
                     EKVVLKNGKKVFGCDICQEVCPHNVEIPTTHILEFKENIIDYLDYDEIQNISNKEFKR
                     RYGDRAFSWRGRNIIKRNMEIILDKYDD"
     gene            17138..17542
                     /locus_tag="KR257_000770"
     CDS             17138..17542
                     /locus_tag="KR257_000770"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888350.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RusA family crossover junction
                     endodeoxyribonuclease"
                     /protein_id="HBH0029497.1"
                     /translation="MIKITIPGRPISKSNFKLHNINGQAWMPSKGKYSKYLAYENMIA
                     GFINQQYQGETVEENLITVLKLFFPNKRMGDLHNYPKSICDGIEKSGIIKNDKQLKPV
                     LLFDFIDKDNPRVEIELYPVSKYDISYNIFEK"
     gene            complement(17799..18794)
                     /locus_tag="KR257_000771"
     CDS             complement(17799..18794)
                     /locus_tag="KR257_000771"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888349.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aldo/keto reductase"
                     /protein_id="HBH0029498.1"
                     /translation="MRNLGNTNMKIKRVGFGGIPIQRITQDDTNLVINELEKQGINFI
                     DSARGYTISEEAIGIAIEGKRDKFFLATKSMSRDYDSMKRDVEISLNNFKTDFIDLYQ
                     FHNVKEEEYDNLFKDKMAYSALLEAKEQGKIKHIGITSHNLNTIEKAIEDGKFDTIQF
                     PYNIVEGQADEVFKKAHEKGIGIIVMKPLAGGALDNATLAIKYILSKDYIDVVIPGME
                     SVEQVRQNVAVLENLVLDEKDNKEIEEIRNSLGKKFCRRCEYCMPCAVGINIPLSFLC
                     EGYYTRYGLKEWAKEKYEVMDVKPTECIDCGLCESRCPYELPIREMLKTVVEKLG"
     gene            complement(19078..19914)
                     /locus_tag="KR257_000772"
     CDS             complement(19078..19914)
                     /locus_tag="KR257_000772"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429666.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="deoxyribonuclease IV"
                     /protein_id="HBH0029499.1"
                     /translation="MIKLGTHLSIAKGFANAAETAVYIGANTFQFFSRNPRGGNAKEF
                     DEKDIIKFQEIRKENNFAPLLAHAPYTMNLGGTKDDVYEFATRVIDEDIRRMDSLGIE
                     YMCFHPGSHVGGGVDFGIDRIVKGLNNAIKGDENITILLETMSGKGTEIGFKFEQLKS
                     IIDKIEHKEKIGVCLDTCHIFSAGYDIVNDLDGVLEEFDKVIGIERLKTVHLNDSMMP
                     FGDKKDRHAPIGEGKIGLKALIDFMEHPSLKHLPFFLETPFDDEGHKKELKMIKEILS
                     SK"
     gene            complement(20402..20965)
                     /locus_tag="KR257_000773"
     CDS             complement(20402..20965)
                     /locus_tag="KR257_000773"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003417965.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HBH0029500.1"
                     /translation="MKEVLVLRDLECIKAIAHPRRIDILKAFDKSPLSAKQLSQLLEE
                     PHAKINYHIKMLYKVGILELVEEKIKSGIVEKYYYPSAKNVVIGNRILNFSLDNGEEK
                     EELYISKFENMSEVFYKAAEEDVLENENIVDYHDISLTHDELVELSDTMKSKIDEILN
                     KRQHNVEGSKYDIAMVIVPTLEEECPS"
     gene            complement(21063..21992)
                     /gene="glsA"
                     /locus_tag="KR257_000774"
     CDS             complement(21063..21992)
                     /gene="glsA"
                     /locus_tag="KR257_000774"
                     /EC_number="3.5.1.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003417962.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glutaminase A"
                     /protein_id="HBH0029501.1"
                     /translation="MNTLDETLLKEIISSNKKYTNYGQVASYIPELKNARRNDLGICI
                     IDSENNLYSAGNCSTKFTIQSISKPIVLAMALMDNDWEDVFSNVGMEPSGDPFNSIMK
                     LEINDTKKPCNPMINAGAIVTTSLINGSCLEEKEERMLSFFRKLAKNDNIGINYDVYK
                     SEKMTGDRNRAMAYLLKSDGFIRGNVEDVLDLYFKQCSIEIDSVDLARIGINLANYGV
                     DIENGEHLMSEMVSRIVKTFMMTCGMYDASGEFAIKVGIPAKSGVGGGIMASVPGRMG
                     IGVYGPALDKKGNSVAGVKVLEELSNKLKLNIF"
     gene            complement(22541..24208)
                     /locus_tag="KR257_000775"
     CDS             complement(22541..24208)
                     /locus_tag="KR257_000775"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425132.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nucleoside kinase"
                     /protein_id="HBH0029502.1"
                     /translation="MKKINLKIEGKDKEYSLEENSPGIRLGDIAKEFCDEHKGYITLA
                     VVDNKLKELNCRVKKDCEINFLDTTNEDGERVYFRVMSFIFVMACREIFWDSRVTIEH
                     SLSDGLYCEVHIDRKLKEADVENIKNKMKEIVNNDYVIEKIEVTRNEAISIFENNEMY
                     EKAELLKYKEYDSAKVYKCRNYIDHFYGYMLPSTGYIKSFDIKLYNGGVIILGPSEED
                     KTLPMKFVPQPKLSSVYYEAEEWSRLMGIDKVVSLNKIIENNEYGDIIRTFEALHEKK
                     LSQIADMIKDGNKRVVLIAAPSSSGKTSFAHRLSIHLRVNNLNPISISLDDYFIDRKH
                     TPLDEYGNYDFESIYAIDLEKFNLDLKKLLAGEEIDDIRFNFKEGKREYTGKKIKIDS
                     NQPIILEGIHGLNPILTSSIPDEDKFKIYISALTQINLDDHNRIPTADLRMIRRIVRD
                     YNFRGYSADNTILQWASVRRGEKKNIFPYQEEADAIFNSACVYELAVLKRFAKPLLEE
                     IKEDNPAHIEATRLLKFLQYFVELDDTSDIPGISILREFIGGSKIVD"
     gene            complement(24282..25037)
                     /locus_tag="KR257_000776"
     CDS             complement(24282..25037)
                     /locus_tag="KR257_000776"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860855.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TIM barrel protein"
                     /protein_id="HBH0029503.1"
                     /translation="MAVGIASLLFNIEEALNICESIKQITHLEIGIDNISECSELCKY
                     KERISKLGLSIGIHLPMELNTCENIEYIRNSWINFIEKIEFELKGFDLRYFNLHLGYV
                     MTNRVRKNRDKYLGNSVDFLDKLNTNSYVCIENTYSKGGDFSNIGNISYDFEYIFKRI
                     KNSKICFCYDTGHCLIDEDAYVKNLKDKIRLIHLSDNDGINDTHVGIGRGILSEEGIK
                     EVLTLDAEYLVLEINYEDIEDTISKLNNIVGEG"
     gene            complement(25047..25583)
                     /gene="lepB"
                     /locus_tag="KR257_000777"
     CDS             complement(25047..25583)
                     /gene="lepB"
                     /locus_tag="KR257_000777"
                     /EC_number="3.4.21.89"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003417934.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="signal peptidase I"
                     /protein_id="HBH0029504.1"
                     /translation="MNETIKEEIVEWIKIIITALFFAFIITRFIKPTLVNGESMYPTL
                     KSHDYLVANRMTYKLSEPKCGDIMIFKTDLLQENGRKKELVKRVIGVPGDHLKIKDSK
                     VYINGKLLNEVSYIHDNYTEGDIDMVIPKGKVFAMGDNREVSLDSRYKEVGLVDEENI
                     KGKVILRVFPFTDIGIFE"
     gene            complement(25749..26285)
                     /gene="lepB"
                     /locus_tag="KR257_000778"
     CDS             complement(25749..26285)
                     /gene="lepB"
                     /locus_tag="KR257_000778"
                     /EC_number="3.4.21.89"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003417931.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="signal peptidase I"
                     /protein_id="HBH0029505.1"
                     /translation="MGEAVKKEVVEWIKVIVIALVLAFAITRFIVPTIVKGESMYPTL
                     VERDYLIVNRIAYKVGEPKYKDIIVFKTDLTEENGKKKDLVKRVIGVPGDHVKIQDSK
                     VYVNDKLLDETSYIHNNRTDGDIDIVVPEGKLFAMGDNREKSLDSRYDEVGLVDEHTI
                     LGKVLVRLYPFSKIGTID"
     gene            complement(26385..27695)
                     /locus_tag="KR257_000779"
     CDS             complement(26385..27695)
                     /locus_tag="KR257_000779"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436985.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RsmB/NOP family class I SAM-dependent RNA
                     methyltransferase"
                     /protein_id="HBH0029506.1"
                     /translation="MTELPNEFLEDIEEILKDEYDDFIKSYEESKTTGLRINTLKIDK
                     KKLFDLELFDLNQIPWAEEGFYYDDKIDRPGRNPLHEAGAYYLQEPSAMSVIPKADIK
                     EGEKVLDMCAAPGGKSTYILSKLNDTGLLVSNEINASRIKALGENLERFGARNCIITN
                     TDSNSLRKTFNGYFDKVIIDAPCSGQGMFRKDEVAISDWSYAKVVECQSIQKEIIRDG
                     YKMLKKDGILIYSTCTFSREENEHVINEFISEYPHAELIEMERLWPHKIKGEGHFVAK
                     IKKLEEEECNVKELKIKNLDKEIKDYREFEKKFLKVDFYSNKKNKFYLRGENLYLLPE
                     IYPDTKKLKVLRYGLHLGVLKKNRFEPSHALSHYLKVEDVKNVENFSVQSESILKYLK
                     GDVVNSNDSRGWVLVSVEGIPLGWGKESSGVIKNHYPKGLRKVF"
     gene            complement(27774..28490)
                     /locus_tag="KR257_000780"
     CDS             complement(27774..28490)
                     /locus_tag="KR257_000780"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009901989.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PrsW family intramembrane metalloprotease"
                     /protein_id="HBH0029507.1"
                     /translation="MKLDLFLLAIVPILIGMFWIRSKDRYCREPLIHLIKFFLIGAFL
                     SVIIILLENLLMKFNVFEGYSELIYVSFVVAGLVEEGVKALILIPALIKEKHFTEKLD
                     GIIYSVFLALGFATIENMVYIFSESRNLALQVGINRAVISIPAHVMFAITMGYYISKY
                     KFEGNKNKRREYLFMAVLIPILLHGVFDFILMIEYRWAIILLIVYVIILWKINLDKLE
                     KYMNHSKKVFFGNLRKKKKK"
     gene            28735..30006
                     /gene="sleC"
                     /locus_tag="KR257_000781"
     CDS             28735..30006
                     /gene="sleC"
                     /locus_tag="KR257_000781"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425119.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="spore cortex-lytic protein SleC"
                     /protein_id="HBH0029508.1"
                     /translation="MQDGFLTVSIIDATNNRPIQNAVVNIYSMSNGSQSSSTLYQNLR
                     SNESGQVTGLVLPAPDVDYSLQPSDVRPYSQYIVEAIADGYETVVIEGTQLLATIEAR
                     QGVPMSPRTRSKRSFSRQSELIFDIGEHTLYGTYPPKIPESNLKPLPPPTGFVVLDNP
                     VVPEFIVVHDGLPEDSSAPNYWIPFKEYIKNIASSEIYSTWPEQTIYANVIAIISFTL
                     NRVFTEWYRNKGYNFTITSTTAYDHKFINNRNLFEPINVVVDAIFNTFIKRPPTSRQP
                     LLAQYCDGQKSQCPDQMTQWGSKDLGDQGYDYESILRYFYGDEIVFERAPIVSGVPVS
                     FPGTTLQVGSSGQYVRTIQNQLNAISNSYPAVPKVIEDGIYGTDTENAVKIFQGIFGL
                     PQSGVVDFKTWYEISRVYVATTRIASLNPLI"
     gene            complement(30514..31170)
                     /locus_tag="KR257_000782"
     CDS             complement(30514..31170)
                     /locus_tag="KR257_000782"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003417924.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0029509.1"
                     /translation="MKKGDFIWSGVLICIIAVLAIPSSREVFMEATGAHPYIGGFLKF
                     AVLATMGDLLGARILYKDWKIPVGVFYRAIVWGIIGVVTTYGMSIYSSGVGQAQVDGM
                     LPFEGIAFANALFKSATMNILMSPTVFLFHKVMDCFIDKKYEVGKGIKVKLKDVVNIV
                     DWNAYLGFSVLKTIPFFWIPCHTIVFLFPAEYRVIASAFASIALGLILALANKSKVAV
                     "
     gene            complement(32442..32852)
                     /locus_tag="KR257_000783"
     CDS             complement(32442..32852)
                     /locus_tag="KR257_000783"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003439126.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0029510.1"
                     /translation="MKIKKSLISAMMVSAMVLGGTGAVFANGNDSSNIALPKLESLIK
                     SGITDPTELEKYGVEHYTYEEYAKHIQELKDYAKDPNAVKDVSQKDLEETIKKMEQEL
                     EKIKTEGLKIMKPITIENEDGSQISIAYNYAAID"
     gene            complement(33068..34450)
                     /locus_tag="KR257_000784"
     CDS             complement(33068..34450)
                     /locus_tag="KR257_000784"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425112.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="M56 family metallopeptidase"
                     /protein_id="HBH0029511.1"
                     /translation="MFIKLLEMSFTSGVLLLIVIFIRACLFKKLPKKVFVLLWLIVLF
                     KLLIPVSLNSGFSIYSIIESTFDVELGNTSTENYTLKKASDSTGKNNSDEFEIMSNIE
                     NIMMLEMLGILSFIVTIMFSILLCFRYFKIINLFKTSIHIKNHEFIKKWMCKNSRFRR
                     FIVCISEFTRTPLTSGILKPRIILPKQMNYANNQTLDFVLTHEMVHINSFDNLLKLFM
                     LVALVVHWFNPLVWVMFFLLNKDIEFSCDEKVMSILGEEYRADYATTLISLAEENNPF
                     SMTICSGFGKTKIEKRIVNIMKFKKSTYVTFLVSTVLVCGTGLVFATENKEINEVESF
                     GLTKNEQSDKIGFSISSKSTDLYSPKVESDILVSKAKSDGETHFSTAKVSVIEFREHE
                     ESSMSKVTNSENSEETYVNKSSNGKDVLYTDSGEVSIEQSGYNDNRFVISRKGNLLAV
                     NKEQYRTWIE"
     gene            complement(34461..34820)
                     /locus_tag="KR257_000785"
     CDS             complement(34461..34820)
                     /locus_tag="KR257_000785"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888340.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="BlaI/MecI/CopY family transcriptional regulator"
                     /protein_id="HBH0029512.1"
                     /translation="MEIKLFDSELKVMEVLWERGESKAGELVKILKEETGWNRNTTYT
                     VIKKLVSKGAIERIEPNFVCKALISKEEVQKQETETLINKMFGGSSEKFLSAFINKEN
                     LSSDEITKLKQIVEKLK"
     gene            complement(35025..35804)
                     /locus_tag="KR257_000786"
     CDS             complement(35025..35804)
                     /locus_tag="KR257_000786"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888339.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF975 family protein"
                     /protein_id="HBH0029513.1"
                     /translation="MVSRQELKRVSKAQLSGNWGICAISMAVYIALIVLISIVGLPFE
                     PLTTIVVAVIAFCVSAGFTCMFLKITKDEKVKIGDIFVSGRIYLRSFGFYLFESIIVY
                     IYSFIITIIGAFLSFGVLLTSGAIEYLSSDNVGIGTVISTGITLVLIILVLMLPVYIL
                     LLYVSQATFLICEDKDNMGVFKSMGASLDMMKGNVLKLFVLNFSFIGWYILSIATLGI
                     GLLWLIPYVGVTNCNFYRQLVKENPDVEDILLDKEKSYTMY"
     gene            complement(36265..36876)
                     /locus_tag="KR257_000787"
     CDS             complement(36265..36876)
                     /locus_tag="KR257_000787"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003439113.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="lipoprotein"
                     /protein_id="HBH0029514.1"
                     /translation="MKMVKKLILSTIMALVLVLTIGCSNAEEKVKSNFEANLAALEMY
                     KYDEKGISDALTEAEYKQIQTYNSKDKVSMIAQLTPLYGKENAEKIYETIVKLIQGVE
                     KTVTVESSSKDKITLKVVSKALDTSKVMSEANTLVKSYVTDEKNYDKKEKEVQDDMTK
                     MIIDLYNKKPTKEVTTMITYTKKDGKWQPPSNIQKLCEGIYTI"
     gene            complement(36968..37957)
                     /locus_tag="KR257_000788"
     CDS             complement(36968..37957)
                     /locus_tag="KR257_000788"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003439110.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ornithine cyclodeaminase family protein"
                     /protein_id="HBH0029515.1"
                     /translation="MLLLKKDDIKKVFTMRDAIEADKEAFRIYCEGKSVNPLRTNISV
                     PSQDASMLFMPGYIEELGCGGIKIVSVFPKNAQKGKPVIPATVLLLDGETGEVSAVLD
                     GTYVTQIRTGAASGAAIDVLAKKDSKIGALIGLGGQGEPQLEAMIEARNLDEVRVFSR
                     NKESREKFAEEMNLKLSKYNTKIVAVESSDEAINNADVIVLATPSKQPVLNGNLVKKG
                     ALISAVGSYMPDMQELCPNCLTRASKIFFESTDAVLSESGDILIPLKEGKISKDDFSG
                     DLGNVINGTIPGREDDDEIIVFKTVGIGVQDVVTAKRIYDKAKENGIGIDWKW"
     gene            complement(38024..38887)
                     /locus_tag="KR257_000789"
     CDS             complement(38024..38887)
                     /locus_tag="KR257_000789"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728560.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3298 and DUF4163 domain-containing protein"
                     /protein_id="HBH0029516.1"
                     /translation="MKFFKVDTKAKVLRYVFVLTLTIMAVLAIKHDYKYNNLRKDASI
                     NLNSNKEAVTVMSNQSLPKGNTNSKQTLSVSTIGSKTIVKNDEYLESTINMPVITNSN
                     KIVERSTNDKIKNDIFEFYNKSYKEAKQYLKDNPDEKNKFVANVDFELKKNTDSALSI
                     KVRYYTYSGGAHGFYQDIAYNVDMRTGKFLELMDLFKDNTKYKEVIDEEIKRQIAELE
                     KKDEENIGIYNFKGIKENQNFYLQDENLVVYFDLYDITPYAAGIPEFSINKALISSML
                     KPEYVDLFDLK"
     gene            complement(38993..39589)
                     /locus_tag="KR257_000790"
     CDS             complement(38993..39589)
                     /locus_tag="KR257_000790"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895569.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="chemotaxis protein CheB"
                     /protein_id="HBH0029517.1"
                     /translation="MERFNNMVIAIGASVGGTEAILEIIKDLPKSTPGIVVVQHMPAI
                     FTYMYAQRLDKQCIMNVREAKNNDRVEQGNVLIAPGGYQMKLCTDKQGYYVTCEKGER
                     ISGHCPSVDVLFDSVAEVAGKNSIGIILTGMGYDGANGLLKMKENGSFTIGQDENSCI
                     VYGMPMVAFDRGSVMLQLPLGEISNCLIRHINILKQKD"
     gene            complement(39629..40432)
                     /locus_tag="KR257_000791"
     CDS             complement(39629..40432)
                     /locus_tag="KR257_000791"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003417907.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="protein-glutamate O-methyltransferase CheR"
                     /protein_id="HBH0029518.1"
                     /translation="MIKLTDEEFIVLVNYVKKEYGIDLSKKRALIEGRLYNTMIEKKL
                     SSFSQYMNLLFKDKTGNEAINLINRLSTNHTFFMREPQHFEFIQNSILPFWEENNKIR
                     NINIWSAGCSSGEEAYSIAMTLDDYFGYNKELWNIKIIATDISTNSLEKAKRGIYIES
                     NVNNVPELWKKKYFIDNKDGTFKICDKIRKSVIFKPFNLMNDFSYQHFDLIFCRNVMI
                     YFDLKTREELINKFYNATKKDSFLFVGHAEVINRSSTKYKYVKPAIYKR"
     gene            complement(40468..40908)
                     /locus_tag="KR257_000792"
     CDS             complement(40468..40908)
                     /locus_tag="KR257_000792"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003439104.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="chemotaxis protein CheW"
                     /protein_id="HBH0029519.1"
                     /translation="MAKDEIIKQVLTFYVNDVIYGIELENVIETIRFQSITYVPCLPT
                     YISGVINLRGRIIPVINMHIKYNLPKADYNERTCIIITKVDEYQVGIIVDKVVDVIHI
                     ENLNLLETTNSNNTNINKDIKEIAKVEDNSILILDIRKFLINSI"
     gene            complement(40921..43023)
                     /locus_tag="KR257_000793"
     CDS             complement(40921..43023)
                     /locus_tag="KR257_000793"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860851.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="chemotaxis protein CheA"
                     /protein_id="HBH0029520.1"
                     /translation="MRQMLDMFIFETSLLLEQLDEIMIQIEKEKVFTHNNINETFRIM
                     HTIKGSASMMGLDNISALAHSVEDLFYAIREGKIEVLDNDLLFDLVFQSLDFIRRDID
                     ELQSRGCISSDYSNFIEGIEEYVSTLELSSSMKSKDNANLESKDEKEVIDSNFEYKED
                     SDVVKIIFEQGCMMENVRAFMLVFELRDYCEFIDFYPKDVETNAESTEYIKSYGFYIQ
                     FVAKEDKAIVYKTIEDNLYVKEYINISKKEIEMKNTSNNDAVENKLKDNNKVSKSYQN
                     NYTEDEIQEDVLNEKTDMEKDSLSEENEHLPISKQSIMSVNLEKLDLLQNIVGEIVIM
                     ESMVVNSVNSTGVDIDNFNKATRQLHKLTDELQDIVMSMRMIQIAGVFQKMHRIVRDM
                     NKKLDKNVELITIGAETEVDKSVIDNLAEPFMHLIRNAMDHAIEPIEERIAKGKEEVG
                     KIVLSAENLGGEAVISISDDGRGIMRDKILAKAKEQGLLKHQSNEYTDDEVNSLIMTP
                     GFSTKESITEFSGRGVGMDIVRKSIEKVGGSIEVKSKQDEGTTFTIKIPLTLSIVEGM
                     KFKVGDSLFTLPISSIRRTFKLTDLNQIITEGNKTELITIYGACIPIIRLHKIYNIQT
                     KVTNLMNGNMIIIENEHKAVCIFVDEIIGNQQVVVKPFPVYFNRFNIKNKGLSGCTIL
                     GDGSISLIIDADSIIEIY"
     gene            complement(43284..44987)
                     /locus_tag="KR257_000794"
     CDS             complement(43284..44987)
                     /locus_tag="KR257_000794"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888334.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HAMP domain-containing protein"
                     /protein_id="HBH0029521.1"
                     /translation="MKREVKLSKLAIVLLIIIVLAVLAGIFSSISSYKAFEKVEKSIN
                     DMNNLRTQSQYIKDTTREISDVLRRYVFTGEKKNKDIYEKELYGKTRESALNKLEKIG
                     LTKSESNKILEAKEISDSLVPTEQSAIKAVESNDKSKAQSIIFGSDYINSQEKMDSLI
                     NEFQEDIVTRSNSKIVEVKKELQSLILRTIFILSLLIILTIIEYTVIKLKIVIPINKV
                     EKHFSRIASGDLRTSIDVEESKSEIGLLVSSVKKMQSMLLNYIDLIDSTLTSIAKGDL
                     RVEIDQEFIGDFKSIKISLESIINSFNGDFSEINLSAEQVASASEQVAAGAQALSQGA
                     TEQASSVEELASTINEISDGIKKCADSASLACEVSDQSASQVGFGSRCMDDMMTSMGE
                     ISEKSSEISKIIKTIDEIAFQTNILALNAAVEAARAGQYGRGFAVVADEVRSLAGKSA
                     KAAQNTAILIEEAIKTVENGVRIAKETANALDLVVNGVEKTTNYINGISSAVHSQEVA
                     ITQILSGIEQISIVVQMNSATAEESAAASEEMSAQAQILKELVEKFHLKESEVRESSW
                     V"
     gene            complement(45013..45972)
                     /locus_tag="KR257_000795"
     CDS             complement(45013..45972)
                     /locus_tag="KR257_000795"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895564.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="diguanylate cyclase"
                     /protein_id="HBH0029522.1"
                     /translation="MKNKQQGTILVVDDSVLMCDLIDKTLTKDNFKVKKAFNAIEAKE
                     FIEEFIPDIILLDIILPDNSGFEFCKEVKSNARTADIPIIFITSKNTDTDIVKGFGVG
                     AIDYMVKPFSMTELKARVIAHLEVKKSQDKLKKINNELESSLEKLNRLVVRDYLTGLY
                     NRRHIINQLMEQRRINKYSETSISLILGDIDDFKVINDTYGHEAGDFVLTVISSIIKK
                     NCRQIDTVSRWGGEEFLIMLTNTPIEGAKILSERIRKEIKEFDFNYKEHKIKCTITLG
                     VVEVNSNISLEENISLADKAMYEGKNLGKDCSVVSTMKGLKKI"
     gene            complement(46108..46626)
                     /locus_tag="KR257_000796"
     CDS             complement(46108..46626)
                     /locus_tag="KR257_000796"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003439100.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="purine-binding chemotaxis protein CheW"
                     /protein_id="HBH0029523.1"
                     /translation="MRFPDDPYLDYGLIDEGIKYLKFRVDEQDFGVELEKVIEITGNQ
                     EIIFIPELPTYSKGIINLRGKIIPIIDMRLRLKKDELMTTNCMYIVVTEIKDLVVGFV
                     VDRVDDIVSLEKSKISPPPRVTIEYSDYFVSGVGELEGKIITLLDLEKLLTDKDEVLI
                     DELINGFDCTIM"
     gene            complement(46669..47154)
                     /locus_tag="KR257_000797"
     CDS             complement(46669..47154)
                     /locus_tag="KR257_000797"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425085.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="chemotaxis protein CheD"
                     /protein_id="HBH0029524.1"
                     /translation="MNREIVVNIADMKIAYRPNVLVTYALGSCVGVCLIDKVAGIGGM
                     LHVMLPYSKDAINIENKCKFADTGINELIKSMENIGANRIYIKAKIAGGAQMFLGSSN
                     SVIASIGHRNVEAVKKTLLGLNIPILAEDTGMNYGRTIRFYTETGELLVDSINKGKKK
                     L"
     gene            complement(47151..47768)
                     /locus_tag="KR257_000798"
     CDS             complement(47151..47768)
                     /locus_tag="KR257_000798"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860850.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="chemotaxis protein CheC"
                     /protein_id="HBH0029525.1"
                     /translation="MINYLELDDVHIDALREIGNIGSGNAITALASMINSNVEVLIPM
                     VKILEYNEATNLLGGPENKVVCILLDMKGDINGMFMFLLDESITQLMLSSLFNKEEAF
                     LDEIEAIEISAIKEIGNIMASSYVNAIASMLNMTISVSIPDICIDMVGAVLNVPMIRF
                     SDVGDKVLFIENKFKMSDNYFTSHILMIPEMSSLREILVRLGLEV"
     gene            complement(47833..48195)
                     /locus_tag="KR257_000799"
     CDS             complement(47833..48195)
                     /locus_tag="KR257_000799"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425081.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator"
                     /protein_id="HBH0029526.1"
                     /translation="MENKILIVDDAIFMRMIIKEALSKSGYNNLIEANDGEEACNIFK
                     YEKPDLMLLDITMPKKDGLEVLREIKKLDSSAKVVMCSAIGQENMIVEAIKLGALDFI
                     VKPFKTETLVKVVDNALK"
     gene            complement(48939..49436)
                     /locus_tag="KR257_000800"
     CDS             complement(48939..49436)
                     /locus_tag="KR257_000800"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728567.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="effector binding domain-containing protein"
                     /protein_id="HBH0029527.1"
                     /translation="MNYEIVEINEKIVIGISKETTNKDGQAVNDIGELWKKFMGKGIY
                     NAIKGKKNDKTIGLYTDYQGDFTSPYSFVACCEVNSNSDKEKNLEELNTNNTVGESII
                     SKVIPAGKYAKFVIVGGQKEVGDFWFEFWQMDFDRTYISDFEEYQCNTFDTKKQEVHI
                     YIGIK"
     gene            complement(49611..50522)
                     /locus_tag="KR257_000801"
     CDS             complement(49611..50522)
                     /locus_tag="KR257_000801"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003439096.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YafY family transcriptional regulator"
                     /protein_id="HBH0029528.1"
                     /translation="MKINRLTEIIVILLNKKLVTAKELADRFEVSTRTIYRDIETLSM
                     SGVPVYMTKGKGGGISLIEEYSIDKAILSKKDKESLIVALKTLQATKYPEINSVVNKI
                     GSIFGEQNFSNWIEIDFTEWGSNFNEDDKFTKIKEAILRRNTINFNYVNSLSSQTNRT
                     VEPLKLMYKSKTWYLYGFCKLKDDFRIFRISRIRNLSIKDEVFSRKIIEEVCLNDSKV
                     IKENTITLKLRFKEKMLFRVFDDFNKDLITKNEDDTYDVITEFPIGEWIYGYILSFGD
                     NVEVLEPKDVRDNVITRLRELSKIYSL"
     gene            51447..52298
                     /locus_tag="KR257_000802"
     CDS             51447..52298
                     /locus_tag="KR257_000802"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425075.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3100 domain-containing protein"
                     /protein_id="HBH0029529.1"
                     /translation="MEINKKHFIQVFLTCLILVVICEFIGQRTIAIGKASIVLFPMLY
                     AVIIGLIITPDLLGKKIKALKKVVGEKEINIAGEVVGIALVMLGIKYGTTVGPNIDKI
                     IQAGPAFIAQEFGHILAPIVALPLALMFGMKREAVGATASISREPSLGVISEKYGINS
                     PEGSGVLGTYLMGTVLGTIYFSVLGSISIYSGLHPYALGMACGVGSGSMMTAAAGSLS
                     TMVPPEMADTILAYAATSNMMSSITGIIFLVFVSLPFTNFMYKILEPKFSRNKKTKEI
                     KSTEGEC"
     gene            52302..52772
                     /locus_tag="KR257_000803"
     CDS             52302..52772
                     /locus_tag="KR257_000803"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003417884.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0029530.1"
                     /translation="MFANLNLKKSSYQLLVMSVIGVIILIGQRISVGTSIVTALPGMV
                     MLILAAMAAMIIKDLFPKSIFPAFGFATIIGLLLSMPYSPTSEVFLTNTNNINFMAIT
                     TPLLAFAGISVGNKIEALKEMSWKIVIISLIVFTTIFFACASIAHIVLSIQGKI"
     gene            52785..54095
                     /locus_tag="KR257_000804"
     CDS             52785..54095
                     /locus_tag="KR257_000804"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888329.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amidohydrolase"
                     /protein_id="HBH0029531.1"
                     /translation="MNKEQLKSLVIKTIDENREKILKIGQGIYKNPEYGYKEFKTTEA
                     VSNFFEQELNLSVEKNIAVTGCKADANSSKKGPHISILGELDGISCKEHKDANEIGAS
                     HTCGHNIQIAGMLGAAVGLVKSGVLEHLDGKVSFMATPAEEFIELEYREQLKKEGKIT
                     YFGGKQELIKRGYFDDIDISMMFHASDLGEDKALVGPESNGFVGKKVKFIGKESHAGS
                     APHDGINALNAAMLAINNVNALRETFKESERVRFHPIITKGGDIVNVVPADVHMESYV
                     RARTINGMIDANERINKALMAGGMAVGADVEITEIPGYLPILRYKSLDNLFKNNLEDL
                     GLKGKVIDGGDFTGSFDFGDVSHIMPTLHPMIGGVKGALHTRDFEIVDEDLAYIIPAK
                     AMALTVVDLLFDNAKDAKDILDTFTPVMTKEEYLTFLEKHDKTL"
     gene            54307..55053
                     /locus_tag="KR257_000805"
     CDS             54307..55053
                     /locus_tag="KR257_000805"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009901983.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MBL fold metallo-hydrolase"
                     /protein_id="HBH0029532.1"
                     /translation="MFNAGNRIINTWLYPIQDGFVLIDTGYENGFKHFKKRISKFNIK
                     IKDIRYIFLTHAHDDHVGFLNQILDESPNTKIVMHDKALEILYKGQNSFIGGCTSRTA
                     FLFCQIMKLFGKGEHSFSPLKQEFEKRCILVSDKNRKEIEKELNGKIIDTPGHTADSI
                     SLLIDEGVLFCGDSAMNGFPSTHKITIFAESKLEFIQSWKTIINTKPKMIYPGHGKPF
                     EYSKLEQNLIYVNKINLYPLHNSKDIHRFL"
     gene            55415..56956
                     /locus_tag="KR257_000806"
     CDS             55415..56956
                     /locus_tag="KR257_000806"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003417871.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AbgT family transporter"
                     /protein_id="HBH0029533.1"
                     /translation="MNDNVVKKKNFFDRTLNRIETVGNKLPDPVTIFLGLCVLLLILS
                     SLVGSMGISVVHPGTGETITAVNLLTVEQLQILLGNIVSNFQGFAPLGLVLVTMIGAG
                     VCDKTGLMTATIKASVSKIPETRVTLVVMTIGMLANIASDAGTILFPPLAALVYLGVG
                     RHPLIGLFSGYAAVCLGFAANIMISVNDILAASFTVPAAQMIDSGFQANATMNLFFMI
                     ASTFVLILLATWVTEKIVAPRFGKYEGNAELDVDGSLSDVEKKGLKKAGISILIYVAI
                     IVALSVIGKKPFLADPETGDLLSNNAPLMKGMVPIIALAFFIPGVVYGKTIGKIKKDK
                     DVVSIMASAMSDMGGYIILAFAASQFLQLFTNSNLGLILAVKGGEFLKSAGINGPLLL
                     IGFIILSCFINLFIGSASAKWAILAPIFVPMFMMVGYNPALTQMAYRIGDCITNPLSP
                     LFPYFPIILAFTRKYDKDAGMGTVIANMIPYSISFLIVWTILLILFMVFNIPLGPGIL
                     PSYSM"
     gene            56991..58097
                     /locus_tag="KR257_000807"
     CDS             56991..58097
                     /locus_tag="KR257_000807"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003417868.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="M20/M25/M40 family metallo-hydrolase"
                     /protein_id="HBH0029534.1"
                     /translation="MLDKNRLINNFMDMVRIDSPSNQELEMSKWLVNYLKERNIDAII
                     DDAGEKYGGNTGNVIAYIKGEEGSRPLCLCAHMDQVQPCLGVKPILDGNVVRSDGTTT
                     LGADDKAGIAAILEALEHVITEKIPHRDIYLCFTICEEAGMHGVKNFNPDNLPCKDMV
                     ILDSGGAIGSIAYKAPAQQSIKISFHGKKAHAGIEPEKGLNAILVASHAISNMHIGRI
                     DSLTTSNIGKIEGGGATNIVTDKVTLTAEIRSHIPETLEYELNHMEKCCKDAASKFNT
                     TYTFEHSMSYPSFELSRDSHVFKLSEEAIRQVGVVPNPMVIGGGSDANILANLGYNCA
                     ILSLGMYDVHTVNEYVNIDELYDTAKIVYHMIKL"
     gene            complement(58428..59714)
                     /locus_tag="KR257_000808"
     CDS             complement(58428..59714)
                     /locus_tag="KR257_000808"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003417866.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcriptional regulator"
                     /protein_id="HBH0029535.1"
                     /translation="MIVGIIGPSDSGFKIKDDLKQIDSDLKTKIYVREKVVDTIEVIS
                     KCEDECDAIIFTGCAVYEFIKSKYEISKPHSFVPRSGTSIMKAFWAIKSANIKLDKFS
                     IDVVDRYVVEDALKEFDIKATSVFCNPFSLEVGESELVEWHIKLFEENKTDIMLTGFG
                     AVYNELKERGYPVFRLQATIQLIKESYDKVKSEYALSKARFSQIAVEILSLIDYKEKI
                     DNYYSDMIKKSDMDKLVVNYVRSIQGSLFLLGRNDYVVFVHKGVADNEYNYDKLFNLK
                     REIKDMGFSLSIGIGTGVTAYQAENNAHKALRHSIDSKEIGIYLVDEDENIRGPLASE
                     NELNYSLMLSDEKVIEISKKTGMSCESVAKIIAINENRKSKIYDSKELAEYLNVSERS
                     ARRILNKIVNAGLGRICAKETSIGGGRPKNITEILF"
     gene            complement(59837..62935)
                     /locus_tag="KR257_000809"
     CDS             complement(59837..62935)
                     /locus_tag="KR257_000809"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009904951.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional diguanylate
                     cyclase/phosphodiesterase"
                     /protein_id="HBH0029536.1"
                     /translation="MDVINLIDELDEIVYVSSLDTYELLYINEIGKKAMGLNDISHLK
                     CYKALQGKDSPCEFCTNSILKEDEYYIWENTNTRTNRHFILKDKLIKWEGKHARLEIA
                     LDITEKEDISKSIAEKLEIKELLVGCIKHLITESNFSDAVNLVLTNIGKFHKADRAYV
                     FEVSEDRTKVTNTYEWCNEGVDEQKQALTNLDINELKNWFLLFEQKGFVIIDDIENIK
                     EEQPIEYEILKPQKIESLMTSSLKQDDKVVGFIGVDNPHKAVGDTSLLTSLSYFLLTE
                     MKKRKVENKLNYMSYYDFLTGAYNRNKYIKYIDNFQKGKVKSIGVVFVDINGLKDIND
                     NFGHANGDSAIVSACVIIKKYFHSYNVYRIGGDEFVVLCEDISKQLFEELVSWLSEEF
                     KDEMIYSVAVGSIWSDDNIDIHKLIKVADERMYQDKKRYYNKNKLRNNEMKVISDLAD
                     STNNILFKHKELVDKVYFDDLMIKGYSKAYEKLAYNTYDIILSICIDTNLITPIYQSE
                     SNIFSFPIKENLEKTFSYIKKYLIHPDDIILFNDNHLLKSLDSLNNSKQDDLELNFEY
                     RRLGIDKKYYWALIYMLKISSKNKLGEKQTHILVAIKNIDYLMQLHKNQKDTLTGLYN
                     YESFCEQISLMLKRYPDKRYAIIMMDIDKFKVINDIYGVRGGDKALIYVAELIQKNIG
                     SNGICCRMYADVFCIFYESYSDRDIHKVIYKIKNSLNRKKFEYMLVPCFGVYRILDNH
                     IPITNACEMAGYAHKKVKKQSINNYIFYDDTIRNDALEEKQMEREMEYALENGQFHVY
                     LQPKYNLNANKIVGAEALVRWVHPEKGIIPPIKFISLFEKNGFIIRLDMYVWEQVCSL
                     IRKWIDLGEEPVPISVNVSRLHLHNPHFKEIVLSLINKYSIPKSFLELELTESLFIKN
                     IKLFTKIIADLRMDGIVLNMDDFGSAYSSLNMLKNINIDTLKIDCGFFNEEGITDREK
                     IVLKHTIAMAKDLDMDVVAEGVETKEQAEFLVSLDCVVIQGYYYCKPIPSSDFEKLLY
                     QK"
     gene            63660..63812
                     /locus_tag="KR257_000810"
     CDS             63660..63812
                     /locus_tag="KR257_000810"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895551.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0029537.1"
                     /translation="MKIFSFLLFVVGICFCIAGFMGHSSAFSGATLSFFATTMIAVRQ
                     VKTKKK"
     gene            complement(64105..64809)
                     /locus_tag="KR257_000811"
     CDS             complement(64105..64809)
                     /locus_tag="KR257_000811"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003439080.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HBH0029538.1"
                     /translation="MEIKPLVLIVEDDKPICKFIKVSLETQNYRCVETDNGGTAISLI
                     HSLDPDLIILDLGLPDIDGIEVIGRVRACAKTNKIIVVSAREHERDKVEALDGGADDY
                     LTKPFSVTELLARVRVALRNKAQQDNINNDAPKSFEVKNLKIDYENHIVSINGEEIHL
                     TPIEYKIIELMSKYSGRVLTHKFIIDKVWGNYYESENQSLRVFMASIRRKIEKNPAQP
                     EYILTEVGVGYRMADE"
     gene            complement(64800..66407)
                     /locus_tag="KR257_000812"
     CDS             complement(64800..66407)
                     /locus_tag="KR257_000812"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003417858.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4118 domain-containing protein"
                     /protein_id="HBH0029539.1"
                     /translation="MKKERLQHEDLKEYDYDEDGYLSKKIIIKDFIKTILVMTIATGI
                     SVVFEKVGFNESNIILVYILGVLFATSITYGYFFGILSSVIGVLSFNFFFTHPLYTFL
                     AYRKDYPMTFCIMLMAAIITSTLTSRIKREVRLSHKREKMIRLLYENNKTLLKAKNKN
                     QIIEFCGSNLVNILNRTVIVTIADENNNLGKPSIYICNNDGSENIFHSVLEKEAIKEA
                     FRTGNPVGIGTKYCKNSSAYYFPIKGQESNVLGVIGVACFKIDIITENEKILLEAVST
                     QVALAIDRENLFEKNKKANLEAERERLRGNLLRSISHDLRTPLTSILGSSSTILENDD
                     VIDKETRVELLKNIYEDTSWLTHSVENILSMTRIDEGKLDIEKRPEVVDEIIAESILR
                     VKKFANSRDIKTNIPDEIIIVHVDVLLIEQVLVNLIDNAIRHTPKNSKIELTVKKESN
                     QVLFEVADNGKGIPNEDIGNIFNRFYTKNKSRNLERRGIGLGLEICKSIVEAHGGEIV
                     AFNNPSGGATFRFSIPMYDEEGKDKWK"
     gene            complement(66661..67839)
                     /locus_tag="KR257_000813"
     CDS             complement(66661..67839)
                     /locus_tag="KR257_000813"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003439078.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0029540.1"
                     /translation="MEKLSDKRRVKAVSMETFVFIVLLAVGFGYVGSIMGAGMMFKVI
                     MSTAHALLLDTVFLIMAMAVLAGALSALLSEFGVISLVNKIFKGLMRPIWGLPGASIA
                     GVVATYLSDNPAIIPFAKDKTFTQYFKKYQVPALCNLGTAFGMGLIVTTFMIAQGKEY
                     VLPAIIGNVGAIIGSIISVRIMLTFTKKYYNYDPKNDTEKQINDKGAKLEEFREIRDG
                     NVFQRTLDAILEGGKLGVEMGMAIIPGVLVVCTLVMLLTFGPSTDPATGQAVYTGAAY
                     EGIKLLPAIGDKISFIIEPLFGFTSPEAIAFPVTALGAVGAAISLVPEFIKSGAITPN
                     DIAVFTAMGMCWSGYLSTHIGMMDALDARPLAGKAILSHTIGGLCAGICAHFIFMLVG
                     "
     gene            complement(68065..68559)
                     /locus_tag="KR257_000814"
     CDS             complement(68065..68559)
                     /locus_tag="KR257_000814"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003417852.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="threonine/serine exporter family protein"
                     /protein_id="HBH0029541.1"
                     /translation="MHLFIEVIAAFFTALSFGVLFNMKGKNLILAGIGGSIAWFSYKF
                     LLNMGVTENLCFFIATVCFAIYCELCARIYMTPATTLSVCCLIILVPGYGIYNTMYSV
                     LTNNYIKAVEYGVSTLSCASSIALGLVFITTVFRKVNLYGVLTKIKENEKYKKSINKI
                     KQQK"
     gene            complement(68560..69321)
                     /locus_tag="KR257_000815"
     CDS             complement(68560..69321)
                     /locus_tag="KR257_000815"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888325.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="threonine/serine exporter family protein"
                     /protein_id="HBH0029542.1"
                     /translation="MDIDRILNFSSNAGKAMLQSGGETYRVEETIARICQSFGIDHVD
                     VFATPTAVMASVFVDGKLHSAIKRISSRRVDLNLVHEVNSLSRAISINNLDIELCEKI
                     LDEISEDNYYSDLITIFFAGIAAATFSILFGGNVEEFIAAFTVGILTKFVIMYLSKSS
                     LNDFFVNAIGAVIIASCSILILKLGFIKTLDHLIAGAIMLLVPGLALTNALRDLLDGQ
                     LISGLAKLAEVFFVGVSIAVGMFLVLGLYFKLGGI"
     gene            70043..72877
                     /locus_tag="KR257_000816"
     CDS             70043..72877
                     /locus_tag="KR257_000816"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003417846.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sigma 54-interacting transcriptional regulator"
                     /protein_id="HBH0029543.1"
                     /translation="MLRKDKVLLSLHKLCENMTLKDLQSDKTGFTTIEIANHSSLDRS
                     NTSKELNNLYNEKKVLKISGKPILFLHASIIENLIGRTLNSDEFSINNCNELLKSSKN
                     DSEDIFSTLLGHDSSLKLPIEKAKSAILYPPKGLNTLLIGPTGVGKSTFAETMYKYAV
                     ESKIFSSESKFVVFNCAEYAENANLLLSNLFGYVKGSFTGANKDKFGIVAQADGGILF
                     LDEIHRLPPEGQEMLFLLMDKGIYRRLGESDIVHKANVFIVCATTEDIHSSLLGTFLR
                     RIPVTINLPALQDRSLKERLSLIKYFFIIESKYTNATIKVHKDVIKSLLLYDCFGNIG
                     QLKSDIQLMSARAFLNYKTGLKDNIEIDLSLVPDYIYIGLLKLNENRSNLNKLSELDY
                     MLFYEFNGNNLEVEYTKELSKYNIDTSNNGFKYSTEIPYLENDIRSMFINYMEKYSTK
                     LLSISSVTHSDYTSNEIFKVINPKIYYAVEHSLKEAEKISRNKYTKQTYIALSMHISA
                     LIENINQDTYNPKYNLYNDKIFLDKDLNIAKIVLSIIENDLQTSLPKDEVKFISMFLN
                     SMYLEPNNQSESIGVIILAHGNSTASSMCDVANSLLGTNHCNAIDMPLDVKVSTILDK
                     TIELVKECDEGKGVLLLTDMGSLIAFGELISEKTKIKTRSIEMVSTPIVLEAVRKSTL
                     PEMTLDELANSLSSLNPYIGRAAIDSTEINYPEKSREYVIITTCITGYGSAMKVADFI
                     NSSLKNISKYNINLVPHNIESFKMYKNKFSNTKILAVVGSVDFNVANTPFIHIEELLN
                     GYGLDMLNKIIEGTFNANSITNIKETNLSYNSLIINFMTQNLELLDSVKLFNYVNSSL
                     FTIIELIDENLKSKFKLGYILHCSFMIERCFKNTTFPYNNITELISKNHELYSLIREA
                     FKPTEAYFNILIPDEEIAYIIDMINEYLNK"
     gene            72920..74164
                     /locus_tag="KR257_000817"
     CDS             72920..74164
                     /locus_tag="KR257_000817"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003439074.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="D-alanyl-D-alanine carboxypeptidase"
                     /protein_id="HBH0029544.1"
                     /translation="MEDEILKGKIKQLTILALIFIFITPVFAFADTPPVPNSSRAALL
                     IDQETKRILFEKNIDEKMPLASLSKMMTFLLAIEAVDKNQVKETDMVKIDKSTASVGG
                     STCKLKDGDEISLGELMQGLMLVSGNDAAIAIAKHIGKTEKNFVNMMNKKAEEIGMID
                     TYYFNPNGLPIYTDPEHKEPPIENMSTAHDIVTLGKYMYDHYENQVTRITTMQVYNDT
                     KKDFTHYNTNPLLVSVPGVDGIKTGYTDNAGYCLAFSMMVPKDAKNERNHRLIGVVLG
                     DGNKKNRISSSATLLKYGKDNFHSKKIAHKGDIIETPCVDGIDDFKITVKVDKDLYGV
                     VSDNENINPKVVFKNMNYPIHKGDIVGVVKYYNDSGKFVGSVDVKSESNIGCIPLKDK
                     IKIKVAKINKKLEIKNSVCFKA"
BASE COUNT        24729 a        13018 c         7889 g        29147 t
ORIGIN      
        1 acagtatcat aaaaatataa ttaactgtac ttctaaatta ttgtttttaa aataaatttt
       61 cattcattaa aaaatacaca taaatatttc cagactccga ttcagcaaac ttatataagt
      121 tcacttttta tttatcatca attattttca tatacttctt ttatctcatc ttcacttaag
      181 tcaaaatcat taaatttatt taatatgtca tctaatttaa aaccattttt tttcaacatt
      241 ataattattt tataatcttt ttcttttgca actctaattg ctgtctctct ttcaatctct
      301 tctttaaaat ttctactttt attcatgata taagcacctc ttttcagatt taataaatat
      361 tcttcattgc tacctaattc ttttaatcta tcaagtgctt ttttaataat agaatcattc
      421 ttagctataa ctcttacatc taagttagaa ggattactaa taagttttcc ccatagcata
      481 attctattta ctatatagtc agatttatga atttttggaa gctctataaa atataatgca
      541 gttttactag aataaatatc tggatgcccg tccattgtta atctcaggca atttacataa
      601 tcttctatgt gattatattt tacatgattt agtatatgta ttccaatagt ttttccaatt
      661 tctttatact ctttaccttc ttctaacttt ctaccatgta cacgactaag ataatattca
      721 gctctttcca aataatcgtt ctcaaaagct ctttgcatct caatatttat atgattattt
      781 tcttcatctt cagccaaaat atcaagttta ggtcttttct ctccaatgta attaattgtt
      841 ggatcagttt caactctaat tattctcttt atttgagtga acggtttgat attcctgtta
      901 gcatatggag catcttttag aatatcattt ataaaattta caagtaaatc atattcatta
      961 tttaaagtga acaatgattt aaatacctca tcatactcgg gcttagcata tccatcttca
     1021 gtcacaactt ctccaacatt ttcattagtc aaaatctctt ttggaattaa cgccttgatt
     1081 ttatctaatt catcattaga aaaactactt ctactaagta tatcatttaa ttttttggtc
     1141 cattctttat ctttttcttc aattatagtt cgcttatatt cttttgatgt tttaataatc
     1201 ttagattttt cttctacttt ttctatcatt tcaacacctc tctttttcct cttttgtatt
     1261 tatcatttct tgaaattaaa ctaagtcact acctctttta aaagttcttg ctccataaac
     1321 actttcttaa actctaatgt ctgtgtatgt acttgacatt ctctctctat ctaaagttaa
     1381 ataaattaat ctatgtatag agggtaagtc caaaaataac ataaaacact aattaatcat
     1441 ttataaagca ttaattaatc actgacaatg ctgttattgt caccacatag caccaacata
     1501 gattcttcta ttatagggca attatctatg aaaaatagac tcataagatt agaaaatgta
     1561 cttaaatttt agttcattta aatattcatt ttgaagaaag aaatttaact ttagactaaa
     1621 aaggaaatat ttcaagagga ttaagaaatt ttcttaaagg gataataatt tttatgaaaa
     1681 tggaacaaat atgaaaataa agttatgatt tttacagcca taaccttacc aacaagcact
     1741 taattatcac tcaaaaaata aacgtttatt taaagaatgc acataaatat ttccatgttc
     1801 aaaacacttc tatgatatat ttattaataa atctaccata caaaaaacta gaggtacatt
     1861 aatcataaaa atatgattaa ctgtacctct aattatactc atcttttcat aaatttaatc
     1921 actatgcatc aacatatcaa catattgatt aaacttatct tatataacaa tatcttagct
     1981 actaatataa tatatattag tcttgaataa tactttctct tgattcaatt tcttttgaaa
     2041 tactagctat aaattcatct aatttaatac tacctatttc acctttatct cttgatctaa
     2101 cagaaacatt attatcagct acttcttttt cacctactat tagcatgtat ggcacttttt
     2161 caagctgagc ttctcttatc ttaaatccaa ttttttcagc tctatcatct aattcaactc
     2221 ttataccctt atcaaataac tctttcttaa cttcatttgc ataatccata aatttatcag
     2281 atataggaag tatcttaact tgagttggag ataaccaaac tgggaattta ccagcataat
     2341 gctctattaa tatacctata aatctttcta tactaccaaa agcaacccta tgaatcataa
     2401 ctggtctatg cttttcacca tcttgaccaa tataagtatt atcaaattgt cttggaagct
     2461 gcatatctaa ttggatagta ccacattgcc aagttcttcc taaacaatct tttagatgga
     2521 agtctatctt aggaccatag aatgctccat caccctcatt aatagtatat ggtagaccta
     2581 actcttctaa agcttctctt aatccatttt ctgctgcttc ccactcttcg tcgcttccca
     2641 tagagttctc tggtcttgta gataattcta aattatattc aaatccaaaa gttttgtata
     2701 taccatctat taagttagct actcctttta tttcgtcctt aatttgctct ggtaacatga
     2761 atatatgtga atcgtcttga gtaaatgctc taactctcat taatccttgt aatgcaccag
     2821 ataactcatg tctatgaact ctaccaagct ctgcaactct cattgggaaa tctctatatg
     2881 aatgtagttg agagttataa taaattaatc caccaggaca gttcataggt tttatagcat
     2941 aatcctcatc atctatttta actgtataca tattttcttt gtaatgatac cagtgtcctg
     3001 aagtctccca taattttcta tttaatatga ttggagattc tatctcaata tatccagctt
     3061 ttctgtgtat ttctctccag aattttaata attcattttt aagttccata ccttttggta
     3121 aaaacatagg gaatcctgga ccttcttcag gtatcataaa taatcctaat tctttaccta
     3181 attttctgtg gtctctcttt ttagcttctt ctagtaaatg taagtactct tctaagtctt
     3241 tgtttttctc aaaagaagtt ccatatattc tttgaagcat cttattattt tcgtcaccac
     3301 gccaatatgc acctgctaca ctttgtaatt taacagcttt taccttttta gtagatggta
     3361 aatgtggtcc tctacataaa tcagtaaaat caccttgctt gtagaaagat attatttcac
     3421 tttcaggtaa atcagatata agttctacct tatagtcttc tccttgttct ttcataagct
     3481 ctaaagcttc atttctagga agttcaaatc tttctatttt taaatcttct ttagctattt
     3541 ttttcatttc agcttctatt ttctctaggt cctctggaac taatctatgg tctaaatcta
     3601 tatcatagta gaatccattt tctatacttg gtcctatagc aagctttgct tctgggtaaa
     3661 gtctttttat agcttgagct aatatatgtg ctgatgtatg tctaaaaact tccttacctt
     3721 ctttatcttc aaacttaaat aaattcaagt cacaatcagt atctataatg tggtccagac
     3781 ctacaacctc tccgttcaca gacgctgcta ccacatttct agctaatcct tcactaatgg
     3841 atttagctac atccataaca gaaatagcat tttcaaattc ttttattgag ccatctttta
     3901 aagcaacttt aatcattgtt ttttcctcct tattgaaata atttttagat tttttgtaat
     3961 aaaaaatcgc cccaaatatg tttgggacga tattaattcg cggttccacc caagttggcg
     4021 tatacaagta tatacaaccc tcttgatgac tataaggtcg tcacccgagc actttcacgt
     4081 atagtacaaa acaaatactg ctaataagct cagctccaag gtagttttca aatagaccta
     4141 ttacatgggc tctcagccat agacccaaat tctctgagaa tggtttctac tctactcttc
     4201 ctcttcaaca ctatgatttt taatatattt tcattataac agatagttat acatcaatca
     4261 acattaatgt aatatattaa ttacccatta tttttcatct caatcagctg taaaccaata
     4321 ttcttatatt tttatattaa attaatctct tgatttatag tgatattata atattttcat
     4381 aaatttaaaa tttttaaaac gtatccacat gcatgataga tatgactaga taaatactaa
     4441 aactaatttt tattaaaact aacttctaat ttttgtactc tttttaggtt ttgtatactt
     4501 aaatacaatc aatacttaat atagttaata agtagtacag taaatactta aatactatta
     4561 ataagtaaca caatcaaata aataaataca attaatatct aaatgctatt aataagtaat
     4621 tcactcaaat aggtaaatat aattagtact taaataaatg ctacttctca tatatttaaa
     4681 taaacatagt aattaaccct tgagctatac ctattaaaaa ccctaagaca agccccaaaa
     4741 actctatatg ttttaattct ttcttagcta ttcttattat tatctcttcc aattcatata
     4801 aatctagttc attaatctta tcttcgacca ttttttgtat atctatacgt tcatttgctt
     4861 tatttattat atttttactc aattcatcta tactttgctt aacttcagac tcaattatct
     4921 ctcctagata atcttgtatc atgtttttta taccactcgg gataaatgaa actttctcat
     4981 gtattataat ttttaccctt gcttttatgt atcttacaac ttcttcctta tcttcgtcag
     5041 taatgatatt tgcaagtatt tcgtccatag aaagaaattc ttcttgaatt atttctccta
     5101 catttgctgc tatttctgct cttctctttg gtataagacc tactatttct atatttaaaa
     5161 taggtatttt aataggctct attggtctaa atatcagtct tatagcaact acattcgtaa
     5221 cataacctat aaatccacca ataacagcta atatcagtat cctaattaaa ttatccatta
     5281 taaaattact ccttatcaat tgtatatttg ccagctatat tgtattaatc aagtagatat
     5341 tctttatact taataacact agttatacta tagctttata tacaattata agtcttttgt
     5401 gtcgatttaa aaagaatttt tttaatttta tatggatagc ttttatatgc ttagattcta
     5461 gttttccata attatactaa ctttattttc aaaaattgct tctacagtat ctataatttc
     5521 ctttgagcaa ttattattta acaaatccaa tatttctatt tttttgggac atagagttaa
     5581 taaggtactt attaaaaagt cctcataatt taaattttct cttattacca tatttataat
     5641 ttcttcatca tctatactgt ctatcttatt tccattttta tcgtataaaa caaatgtatt
     5701 atcttccatt atatgaactt taagcaaatc aatcttttct tcttgagtat ctataaagta
     5761 ttttaaaact cttataaatt catcttggtc tttctttatt aaatactcct caactgcaat
     5821 atcacctata gcagaaatat atttcataaa ttctctcatt ctaaatctaa taaaaccttc
     5881 tacatttata aaatcatttt cttctatata atttctcacc ctagtaaata ctgtttctct
     5941 cataaaaatc tcttttttag caaatatgtt cagtgaatat atgtatatat tatttttatc
     6001 ttcaggatat gtacgcccat agcattttag aatgtattct ttcaaaagtt tctctttcat
     6061 tatacttatt atcatactag ttatttccgt tgatatctca tcaatattta aagctctttg
     6121 ttcagcttta gtaccattaa gtattttttt atttaacact tcttgctttg cagaatctat
     6181 cactacttct acaatgtcat tcgtatatat taatctatcg tttacattat tattcctcaa
     6241 aaatttcatg gaagaaatat tatccttctc aaccaaagtt atcgctcctt tcttgtcatg
     6301 agaggaacta tagaacctat atctagtaaa ttttcacagc taagtgtaac tatctccttg
     6361 tttttacttt ctacaaaact ttttatacgt tcatagtcag gatgtttttt aacatctcca
     6421 caaaaagcta gtttatcctt agaaatcaac cctgtacatc cacctataaa tccataattc
     6481 atctcaaata aatttatgtg acctttttct atcaataaac actctatttc tgtattcttc
     6541 atacttttcc aaataccttt atctgatgtt attatagacg ttctatctac tatacagatt
     6601 gagcatttag aatagccctg ctctatattt atctttttaa gtttattatt ttcaatataa
     6661 tctaatattg ctttgtcagt atacttaaaa ttgtgtatag catagtcacc aactatcgca
     6721 atattgtaag gtatatcata agggtatcta tttaataaat tagcttctcc cttaattata
     6781 ttaaatttat atctacttaa taactctttg tattgattat atacattcgg cgcaacaatt
     6841 atatctcctt ttcctaaatt acaaatacat atatccgggt gatattttat gctttcatat
     6901 aattctttac attctattgt ttttattatc tctatatttc ttaattttaa ttcattttcc
     6961 attagataac taattctttt gtccaccaaa gctagacaca aatcgtcatc tagtataaat
     7021 ggttctcttg taaattccat tttttactcc tttttctttt ttttgataaa ttttttatgt
     7081 gaatataaat aaagtgtgta gcagaatttt tctgcccaca cacttattgt tataatttta
     7141 tatagttaat ctaagcttaa ttagtatagc tttgtacagt tggttcaaat ttaataaata
     7201 tatcttttta tcactaatct aaacttaagc agtatattcc gtacagttag cacaaattta
     7261 ataaatatat ctttttattg ctaatctaaa ctcaatcaat atattttgta cagttagact
     7321 aaatttaata aatatatcct tttatcacca atctaaactt aagcagtata ttccatactg
     7381 ttaacacaaa tttaataaat atatcttttt atcactaatc taaacttaat caatatattt
     7441 tgtacagtta gcacaaattt aataaatata tccttttatc accaatctaa acttaagcag
     7501 tatattttta taatcttcta catcaataat taatatgtat ctttcacttt gttatactct
     7561 ttttttatgt attccaaaac atctggtggt atatttctac tgctctttga agtcaagcca
     7621 agttctccat cttttatttt aaattccatt actttacttc ccttaaaacc atcttttgca
     7681 acgttcttta tcagttcata tacaggttgt tctacatctt ttataattga acttattaca
     7741 ttatctggag ccatatcgta ttggtcttta ttaatagcta taactttacc tccattttct
     7801 cttgctacct gaatagctct tttactatca tcctctgtag ctgaaaatac aacatctcta
     7861 tcagaatctc tcatttcctt tgcaatagtt ctagctgatt cagggttttc aaatatattt
     7921 gaatacttaa ctagtaactc agcatcttta tttgaagttt taagcccctt tctaaatcca
     7981 gattcatact tatctctact agaaccctca actcctccta taaaaccaac cttcccagta
     8041 tcagtcattt tacctgcaat aagtcctgct aaatatccag taacattatc ttgaaatgat
     8101 acagaaatta cattagctgg ctgaacttta taagtatagt caactattgc aaattgctgt
     8161 ttgggatatt cagtagcagc ttctttaatt ggctctgcaa atctggctcc aactgctatt
     8221 atcaaatctg gttcatactt atgcagtttt tctatactct ctttaaaact tttagaagtc
     8281 tttggttttt caagttttat cctaacatca aaatcttcgt cagccctttt taaggctgat
     8341 agtacattgt tattatatga ttcgttattt aagttttcgg tatctaacaa tactccaata
     8401 gtttttctta catatgaatc atcttctgtg tcatcttctt tattcttact tttactattt
     8461 gatttatcct tttctgctga agttggcaaa cttttagact cactctgttt cgatttagca
     8521 ctatctatat tagaattatt cttatttact ttatcaaacc caaaatcaaa attacatata
     8581 gctaatataa aaattgtaaa aactactaca aagcaagcca tcaatatcct ttttattttc
     8641 acaaaattca ctccctgatt tagataggtc tgacctacat ctgcatatgt ctttctatat
     8701 atgtctatta taacatccaa ttcacctcat aactaaagtc ataagtattc ttggatatta
     8761 tagtagatta tttattgttc ttattaacat attctaacac atctggagga atattttgag
     8821 aactattttg ggcaagccca gtacttccag acttaactgt gttttctata acttttccgc
     8881 ctttataatt tccttttaca aaactttgta tcagattata agtaggattc tcaaaatctt
     8941 ttacaataga acttataaca ttttctggag ctaactcatg ttggtcttta ttcgttgcta
     9001 taactttttt attttttgcc cttactgcat ctattacagc ttttgaatca tcttcagtag
     9061 tagaaaaaat aatatccact ccattatcca tcattttttt agctatagat tctactgatt
     9121 tgctatcttt aaaaacatct gcatactcaa ctgaaatatc ctttatacta ctattagaaa
     9181 atttaacacc ctctctaaaa cctgattcaa atttatctct actagaactc tttgttcctc
     9241 ctataaaacc aaccttatcg ctttcagtca tttttccagc aattaatcca gctagatatc
     9301 cagatttatt atcttcataa gaaattgaag ttatattaga aggttgcttg tcatactcat
     9361 agtctataat tgcaaattgt tgctttggat atttcttggc taccatctcc aatggttttg
     9421 caaatctagc tcctacagct ataattaaat cgtaattgtc attacataaa atatctatac
     9481 tattagaaaa agttgaggaa tcatctgatt ccactttgtt tgtatctata ttaagtttct
     9541 tttgagcatt gtttaatgct aataaagctg aattattcat agcttcatta tttgttcctt
     9601 caatatctag tatcattgat acagattttt ttgaattact tttatcgctt atatcacttt
     9661 tattatcttt gctagagcta ggattattgc ttgggttatt agcacaccca accaacattc
     9721 cagctatcat tgctacagtt aacatcaata tcaatattct tttgaaacgc attaaatttc
     9781 actcctcata catttacgat atttttatat cctatttact tttacatcct atttactttt
     9841 acatcctatt tataattttt ttatatacaa tttacaagta cattttgaaa tttttttaat
     9901 aaatcttact ataaaaaagt gtgcaataga ttcttatcta tttacacact tccctacaaa
     9961 ctaaatctaa tatatcaaca cttaatttca tccaaaataa atccaattta acatctcaat
    10021 aattaatatt ctatcctaat ttaataaaaa aataaataat gtcatccaaa aatatattat
    10081 ttatttttta agcatatgat accagtaaca ccaggaccag catgtgcacc tatacacaca
    10141 ccaatttgga aaaatctaat ttctttaggt cttaattcat cttgcataac cttagataat
    10201 tgttcttttt ccttaaaatc atcactatat cctatatata caatttggtc tgataaatca
    10261 tcaccacaat ttgattttat caattccatc atcttagaaa ttacattctt ctttcctctt
    10321 acttgagata tttgcgaaac taatccatct cttatttcaa gaatcggttt tatatttaat
    10381 atacttccta ttgctgcctt agtagatgat attctacctc ccttttgtaa atattccaat
    10441 gtatctactg aaaatataac aaaagccttc tcttttaatt catccaaaac aggcaatatt
    10501 tcagcaacag actttccttc acttgcaagt tctcctgctt ttattacaag taaaccagtt
    10561 cccatacaaa gcaagttaga gtcatatgta tatattttac catctacatc attctttgcc
    10621 attacagcac tttgatacgt acctgtagct gtggcagacc ctgctatata aagtatctct
    10681 ctatcctcat ttgtatattt ctcaaaaatt tccttaaatt gggcataagt agcttgagaa
    10741 gtttttggat atacattttc ttctctaagc tttttataaa attcatctcc agatatatca
    10801 attctatcct tgtattctct ttcctccagt ataactgtta atgaaactat atctatatca
    10861 tatttatcta acaaatcttt tggcacgtcc gataaactgt cacagattat ctttagattt
    10921 ttcattaagt atgctccttt ctcatttagg cttgttgaaa ctacctcata tttgggtatc
    10981 ctatttgtct taaagcctcg tacactacaa tagcaactga atttgataaa tttaatgacc
    11041 tagctttttc aacatccaac ataggcactc taatacaagt atccatattt gctttcaaca
    11101 aaggttctgg taatcccttt gtttctttcc caaatactat aaaacaattt tcttcatatt
    11161 tcacatctga atgtgactgt ttagcctttg ttgtagaaaa aaagtattta ctatttggat
    11221 acttttcttg taattcttca aagctatcgt aatattgtat atcagctata tcccaatagt
    11281 caagcccaca tctttttagg tgtttatcat ccaatgaaaa acccagtggt tttactaaat
    11341 gtaaagttga acctgttgct gcacaggttc ttattatatt tcctgtattt tgaggtattt
    11401 ctggttctac taatactata tttaatgaca ttttaatcct ccctaagtat cgcttttatt
    11461 tatcaaattt tattttataa acagaataac aataatatta tactattata taaaataatg
    11521 ttaataataa tttttatttc atgtatataa tagtttttta tctaacattt tcacaagtat
    11581 tattatatca gaaaatccct cttgtacaac ttactttcta aaagttattt cgtttcatta
    11641 agttctttat aataattaca atcttctttt attgggcaac ttgcacattc tggatttcta
    11701 gctttacaca ttcttcttcc atgaaaaatt aatacatgat gtgagtgtga ccatctttct
    11761 tttggtatag cttccataag tgcaaattct gttttttgag gatttggctc gtccactatt
    11821 cctattctat tgctaactct aaatacatga gtatctacag ctattgctgg atgattaaaa
    11881 gcgttactaa gtacaacccc tgccgttttt cttccaacac caggtaattt tataagcttt
    11941 tctaagctat caggtacttc accatcatat aattcacata gctgttcaga tgtatccttt
    12001 attttttgag acttgctttt gtaaatacca caactcttta tctctttact aatttcttca
    12061 atgctcaaat tagcaaagtc tctagctgtg ttgtactttt taaacaactc tgaagtaact
    12121 ttattcactc ttacatcagt acattgtgct gataaaatag ttgctattaa aagttcaaag
    12181 gctgtcccat aatttaactc acatttagca tctgggtaca gtttttctaa ctcgtctaaa
    12241 atcttattta cgtctttttc atttgctgac tcatttttaa ttttaaactt acttttagtt
    12301 tctttacttg ttttttgtgt agccttatta gaactactct tctttgtttt tttctccgtt
    12361 tcaccttttt tagtactttt tttacttact ttgatacttt ttttatcttc ttcaatatcc
    12421 ataaaattct ctatatcttt ctcatcaatt atctcatctt ttttaccaat cattttatct
    12481 atttcttttt catttatctc ttccttctca attatatctt tcttattcat tcctttttta
    12541 tttatctctt ccttctcaat tatatctttc ttatccattt cttttttatt tatctctttc
    12601 ttctcaatta tatctttctt atctattcct tttttattta tctctttctt ctcaattata
    12661 tctttcttat ctattccttt tttatttatc tcttccttct caattatatc tttcttatct
    12721 attccttttt tatttatctc ttccttctca attatatttt tcttatccat tcctttttta
    12781 tttatctctt cttccaaaat tacatctttt tcatttatct cttttagatt tacatttttc
    12841 ataattatcc cccttcaaaa taccaattta taaaacgcta tttataaata gtttaatcat
    12901 atcaacaaaa aaataaacat caatatataa aacatacaaa ataagaattt aatttatata
    12961 tatttacaaa aaaagcaaaa acctattaaa gttcttgctt tttattatac ataaataccc
    13021 attaaattct ataataaact tattcttttg acacagtttg tatcttgctg aaagatatta
    13081 atttttcttt taccaatttc tttatttctt caaatttaac atctgtcaat atctctatag
    13141 cctcttctac tctttcaaca gtatatatct taaattttcc atctcgcact gcatcattaa
    13201 cttcatctga taaaacgaga tttctttgat tttttctagg aattatgacg ccttgctcac
    13261 catttaaccc tttagtttta catatagaat aaaatccttc tatcttttca cttataccac
    13321 caactacttg tatatcaccc ttttgattta tagaacctgt aacagcaata ttttgtttaa
    13381 ttgatactcc actaagagat gataatagta catataattc tgcagaagat gcactatctc
    13441 catctattcc accataattt tgttcaaaac aaacatatgc atttagtgac aatagtaaat
    13501 cctgtgcaaa attctcagaa agatagccac ctaatataag tactcctttg ttatgtatag
    13561 agccactcat atttacttct ctttctatat ttactatgcc tttacttcct gggctagtgg
    13621 tcgctgtaat ccttgaagct ctaccaaaag agtattctcc tgtacttaag actgacaaac
    13681 catttatcac tcctactttt cttccctctg tttctattag agtaaatcca ttttcaattg
    13741 attcatccat atgtgtttcc actctattga ttctttttct cttttcactt attgcttttt
    13801 taacatcaca ctgctttgta tactccgaat ttctaaactc tgcataagca cttccttcta
    13861 ttacaacttc cattatttta ttaaacttag ttgataattt ttctaaatca ccagataatc
    13921 tagtgctaaa tttaataacc tcttcaactg ctgatttagt aaaatgcctt aaattattct
    13981 tatcacattg gtatgctata aatcttgcta ttccttcttc attatcttca tttttatcca
    14041 tttcactatc aaagtctaca aatactttaa aatatttttc aaaatcttca tcatatctat
    14101 ataaaatatc atatatatag tggcttccaa tcagtactaa tttaacatcc aatggcatat
    14161 tttctggttt aattgctgtt tgtgtttcca atattacttt tttagtctgc aaagtctttt
    14221 taagaatttc ccaagacatt gtatatttta gtaattggtc tgcataaagt actaaataac
    14281 caccattagc cctatgaaat gctcctgata atagttttgt gaaatcagtc tttatatttc
    14341 catttgcata atcatactct gcctttccaa atagatttgc tggacttggg tttatctcta
    14401 ctacaacagg tgctgattct ttattctttg agcttccatt gtctacaaat aggttaattt
    14461 tatatttaat aaaatgctct ttatcatact tatcttttaa ctcctcttca tctaaataga
    14521 ataaatacat atattctatt atatctttct ttatattttc cagataagtt tgaatcttat
    14581 cataattttc atatttttca cacaatctct tgatatgagg ttctactaca agtttagcta
    14641 tctcttcttc aagctctaac actgcttttt cagctatttc ttctaagttt ctaattttat
    14701 atacgacctg tatcgccata ttttctagtt ctcttttagc tttgtaaaac tcttcatcag
    14761 actcatcact ttcatcttcc tcttctttca aagggataaa aactattccc attttactct
    14821 gttttaattt aaatcctttt tcttctccat attttttaat ttgcttcaaa agcatatctt
    14881 tttctatttc atattcatcc agaagtttat ttttttctat ttcaaaattt tcactttcaa
    14941 acgcattttt aaaatcttct aaaagacttt caattaattt ctccatatct ttcttaagtt
    15001 ctcttccaaa ccccttttct aattcaacta taataggctc tctagggttt tcaaaattat
    15061 atatataaca ccaatcttta tgcgtatttt ttttggatgc atactcattt aaaaccttta
    15121 aggcataagt acttttacca gttccaggtt caccagctat atatatgttg tacgctggat
    15181 tatttatttt caaccctaat tccatagctt ctacagctct ttcttgaccc aatatataat
    15241 ctagtggatt tatttcagat gtattattat atttcaatat tcccccacct ccccatattt
    15301 aactttaatg atataatatg acttttacac aacaagtgtt aaagtaaata cacattaaag
    15361 tatatgaaac agactcttat tattagtcat catacttatc taaaattatt tccatatttc
    15421 tctttattat atttctacct ctccagctaa aagctctatc tccatatctc cttttaaatt
    15481 ctttatttga aatattttgt atctcatcat aatccaaata atctattata ttttctttaa
    15541 attccaaaat atgagttgtt ggtatttcaa cattatgtgg acatacttct tgacaaatat
    15601 cgcatccaaa tacctttttg ccattcttta aaacaacttt ttctttctct gacaaatctc
    15661 cttttttttg agttatatat gataaacatt ttttggggtt catatcataa tttcccaata
    15721 tagcatttcc cggacaatat tttacacact taccacattt aaaacaactt ttttctagtg
    15781 gtttatcttc ttcaaattta taattattta ctatataccc tataaatacg taagaaccat
    15841 attcatcagt tatgatatta ttatttattc caaaatatcc tattcctgat aaataagcta
    15901 aatacctgtc aactaatggt ccattatcag caaataactt gtatttaaaa tctgttactg
    15961 ttttagaaat ataatcacaa atttgttgta aaaagtcctt tactacaatg tgataatcct
    16021 ttccatgaca atattttgat aaatttgaat ttttattctt ttcttgtcta tttatatgat
    16081 atggaaatgc acagactatt atagagttag catccttcat tatatgtctt gggttaattc
    16141 tgctctcaat tattggttct tccataccag ttaaataacc tttttgttgt ctgttcttaa
    16201 gtatcttttc taaattatca tatttatcta cccctgctac tcctacacag tttaatccta
    16261 ttaaattaca aaatgctttt aattccttat tatccataaa attattcctt tttaatctaa
    16321 ttgacttttt aaatttattt aattttttta gtctttttaa ccttttctag ctactaactc
    16381 ttttaaatac ttaatctttt tagctattca attttcttac ctgcttaact cttttagata
    16441 cttcgtcttt ttatctattt aattttttta cctactaact cttttaggta cttcgtcttt
    16501 ttacctattt aattttttac ctactaactc ttttagatac ttcatctttt tacctattta
    16561 gttttttacc tactaactct tttagatact tcatcttttt tatttactta tttaactttt
    16621 ttacctacta actcttttag atacttagcc tttttcattt acttatttaa cttttttacc
    16681 tacttaactc ttttagatac ttagcctttt taatctattc aacctttttt acccacttaa
    16741 ccttcttacc ttttaatata aactctaaaa cttcaaatat cattagttat attttgacat
    16801 tctttctata gttaagcaaa aagattgatt ttttcttata attaatatcc catttacatt
    16861 gccatttatt aagtctttac ttgacttata tggatttctt tttactctct ttactaaact
    16921 tatacttatt aatattatga aggtcttata atagtctaat atgaatatgc ccatcatata
    16981 tcaaatttta aaatttgtaa gcaaaatact tatcttatat tactacatct aaagtggaaa
    17041 attttacaaa caagctctgt aaaaacactt taaataacaa tttgctttta aatcatatac
    17101 agattataat aaatactgta taaggatggt gaaaaatttg attaaaataa caattccagg
    17161 tagacctatt agtaaatcta attttaagct tcataacata aatggtcaag catggatgcc
    17221 ttcaaaggga aaatattcta agtatcttgc atacgaaaac atgattgcag gttttataaa
    17281 ccaacagtat caaggggaaa ctgttgaaga aaatctaata acagtcttga aattattctt
    17341 cccaaataag agaatggggg atttacataa ttatccaaaa agtatttgtg atggtattga
    17401 aaaaagtgga ataataaaaa atgataaaca acttaagcca gtacttttat ttgattttat
    17461 agataaagat aaccctaggg ttgaaattga actttatcca gtatctaaat acgatatatc
    17521 ctataatatt tttgaaaaat aaagatttta tgtgttattc gacattatat tgatactcca
    17581 gtatttgaaa ctatactaat acaacaataa taattgtgtt atgtctatac tcaaacaaat
    17641 gtttttaaaa agcattaagt aaatatttaa taagtattaa acaaatatta aatttatata
    17701 atagctataa ctatgtaaat ttaatatttg tatataagac cacatctaat aaaaagaaat
    17761 cggagtaaat ttaatacacc gatttcaata aataaaatct atcctagctt ttcaacaaca
    17821 gtcttaagca tttctcttat aggaagttca tatggacatc tactctcgca aagcccacag
    17881 tcaatacact cagtaggttt aacatccata acctcatatt tttctttagc ccactctttt
    17941 aatccatatc tagtataata accttcacat aaaaaactca atggtatatt tattcctaca
    18001 gcacaaggca tacaatattc gcatcttcta cagaattttt tacctaaaga atttcttatt
    18061 tcttcaattt ccttattatc tttttcatct agcacaagat tttcaagtac agcgacattt
    18121 tgtctaacct gttcaacact ctccatacct ggtataacta catctatgta atctttagat
    18181 agtatatatt taatagccag tgttgcattg tctaaagcac ctccagctaa aggtttcatt
    18241 actattatcc caattccttt ttcatgagct tttttaaaca cttcatctgc ttgtccttca
    18301 actatattgt aagggaattg tatagtgtca aattttccat cttctatagc tttttctata
    18361 gtatttaaat tgtgactagt tataccaata tgttttatct taccttgctc ctttgcctct
    18421 aaaagggcac tataagccat tttatcttta aaaagattat catactcctc ttctttaaca
    18481 ttatggaatt gatataaatc tataaaatca gttttaaaat tatttaaact tatttcaaca
    18541 tctctcttca ttgaatcata atctctggac atacttttag tagctaagaa aaatttatct
    18601 ctttttcctt caatggcaat tccgattgct tcctcactta ttgtataccc tcttgcacta
    18661 tcaataaagt ttattccttg tttttctaac tcatttataa ctaagttagt atcatcttga
    18721 gtaatccttt gtattggaat gcccccaaag ccaactctct ttattttcat gttagtattg
    18781 cctaaatttc tcatatcttt ccccacctaa cttttaataa ttttttatat aatataaata
    18841 tgtcatcttt aattatacaa caaattatga gaatctttgc aatatattta catactattc
    18901 atagtataat tatattttat atcagtctat tcataatata atcatacttt atacccagtt
    18961 aatttgtata caatttttgt tattcctatc cattaattta aattatcaca tttcatgatt
    19021 gtatctccac cctaattatg ttgagggtga agtatttcac atatttttaa taaaggttta
    19081 tttactagat agtatttctt ttatcatttt aagctctttc ttgtgacctt catcatcaaa
    19141 aggagtttct aagaaaaatg gtaaatgttt tagactagga tgttccataa aatcaattaa
    19201 tgcttttaat cctatctttc cttcccctat aggagcatgt ctgtcttttt tatctccaaa
    19261 tggcatcata ctatcattta gatggacagt tttcaatctt tctatgccta taaccttatc
    19321 aaattcttcc aaaaccccat ctaaatcatt cactatatca taaccagctg aaaaaatatg
    19381 acatgtatca agacacacac ctattttttc tttatgctca attttgtcta ttatactttt
    19441 taattgctca aatttaaaac ctatttcagt tccctttccc gacatagttt caagaagtat
    19501 agttatattt tcatcaccct ttatggcatt gttcaatcct tttactattc tatctatgcc
    19561 aaaatctaca ccaccaccta catgacttcc aggatgaaaa cacatgtatt caattcctaa
    19621 tgagtccatc cttcttatat cctcatctat cacccttgtt gcaaattcgt atacatcatc
    19681 ctttgtacca cccagattca tagtatatgg tgcatgtgca agcagtggtg caaaattatt
    19741 ttcttttcta atttcttgaa atttaattat atctttttca tcaaattctt tagcatttcc
    19801 tcctcttgga tttctactaa aaaattgaaa tgtatttgca ccaatatata cagctgtctc
    19861 agccgcatta gcaaatcctt ttgctattga aagatgtgtt cctaatttaa tcatattaat
    19921 ctccttttat ttgtactact acttgtactc aattttaatt ttgaactact ccaccttaac
    19981 tacatttagc caacatatga agatggagat tcctatttga tagtactttt tcactaaaaa
    20041 ttcgtaagct ctaagggatg ttctatccca actaatctca gtcctctttt aacatatttc
    20101 tagcattgat ttaatttata ttaattttta attttaatat ttacacttta attataccca
    20161 ttttaatcaa tttcaaatat tataatctta catactttgt atattatcta agcacttctt
    20221 agatagtgta tacatcttac actatacata ttatttacaa atacaatagg tataaaaaaa
    20281 caaaaaaata gagattaaaa atcattgttt tacccatacc aaaaactatt ttttgattat
    20341 taagtaaatt ttgatgttca atctctaata ttatatcttt aattaatcca taattaattc
    20401 tctaactagg acattcctcc tcaagagtag gaactataac catagctata tcatacttag
    20461 aaccttcaac attgtgttgt cttttattta aaatttcatc tatctttgac ttcatagtgt
    20521 cactaagttc aactaattca tcatgagtaa gagaaatatc atgataatca actatatttt
    20581 cattttctaa aacatcttcc tctgctgcct tataaaaaac ttcactcata ttttcaaatt
    20641 ttgatatgta caattcttct ttttcttccc cattgtctaa agaaaaatta agtatcctat
    20701 tccctataac cacatttttt gcacttggat aatagtactt ttccacaatc cccgacttta
    20761 ttttttcctc aactaattct aaaataccaa ctttgtataa catttttata tggtagttta
    20821 tttttgcatg aggttcttcc aataattgag ataattgttt tgctgacaat ggcgatttgt
    20881 caaatgcttt tagaatatct attctacgtg gatgcgcaat agcctttatg cactccaaat
    20941 ctcgtaatac caatacctct ttcattgacc cctcctaaaa aatttattta attcatattt
    21001 ctttacaatt taattatata ttaaattata tgttgttgtc aaaaaaatcc tttcttaata
    21061 ttttaaaaaa tatttaattt gagtttattt gacaactcct ctaaaacttt aactcctgcg
    21121 acgctgttac cttttttgtc aagcgcaggt ccataaacac caatccccat gcgtcccggc
    21181 acagaagcca ttataccacc cccaactcca gattttgcag gaatgccaac tttaatagca
    21241 aattccccag aagcatcata cattccacaa gtcatcataa atgtcttgac aatcctagaa
    21301 accatttcac tcattaaatg ctcaccattt tctatatcta ctccataatt tgcaagattt
    21361 attccaattc tcgctaaatc tacagaatct atctcaattg agcattgttt aaaataaagg
    21421 tctagaacat cttctacatt ccctctgata aatccatcac ttttcaataa gtaagccata
    21481 gctctgtttc tatctccagt cattttttca gacttataga catcatagtt tattcctata
    21541 ttatcatttt ttgctaactt tctaaagaaa ctaagcattc tttcttcttt ttcttctaaa
    21601 caactcccat ttataaggga agtggttact atagcccctg catttatcat tggattacag
    21661 ggtttttttg tgtcattaat ttcaagtttc attattgaat taaatgggtc cccacttggc
    21721 tccattccaa cgtttgaaaa aacgtcttcc caatcattat ccataagtgc catagcaagc
    21781 acaattggtt ttgaaatact ttgtatagta aactttgtgc tacagtttcc agcactataa
    21841 agattatttt cgctatctat gatacaaatt cctaaatcat ttcttctagc gttttttaat
    21901 tctgggatgt aactagcgac ttgtccataa ttagtatact tcttattaga acttataatt
    21961 tcttttaata atgtctcatc taacgtattc atatgcacct cttatattat gttatatatt
    22021 ctattttagc acaagtttat actataataa aacaatgtta aaaaaaatta tactttaaaa
    22081 ttattttcta caagaatcaa ttcatttttc aaacaattta aatagtttaa agagcttaat
    22141 aatttagtaa ttcaataatt taacaaccta gtaatttagc aatccagcaa tctaataatc
    22201 cagtaattta aatttttata acaccaaaaa tttctaaccc aacacctttt actcttttac
    22261 tcttttactc ttttactctt ttactctttt actcttttac tcttttactc ttttaaaaaa
    22321 taatcacata aactaacaaa atattaaaca aaaaagtaaa atttaaaata aaaagcttgc
    22381 ttcatacaaa agtataaaac aagccttttt atatatcaac tcaaacttta aaatctgtat
    22441 caatttaatt ctccacttta cacttaatat acttaacata aaccaataac actacttgct
    22501 atgccattta atcttcataa aacaatctat aatacacaca ttaatcaact attttacttc
    22561 ctccaataaa ttccctaaga attgaaatac ctggtatgtc agaagtatcg tccaattcaa
    22621 caaaatactg caaaaacttt agtaatctag tagcttcaat atgtgcagga ttatcttcct
    22681 ttatctcttc caacaaaggt ttcgcaaatc gttttaaaac tgccaattca tatacacaag
    22741 cagagttaaa tatagcatct gcctcctctt ggtacgggaa tatattcttc ttttctcctc
    22801 ttctaactga tgcccattgt aaaatagtat tatcagcact atatcctcta aaattatagt
    22861 ctctaacaat tcttcttatc attctcaaat cagcagtagg gattcgatta tggtcatcca
    22921 aatttatttg agtaagggca cttatgtata tcttaaattt atcttcatct ggtatagatg
    22981 atgttaaaat aggatttagc ccatgtatac cttctaatat aattggctga tttgaatcta
    23041 tctttatctt tttaccagtg tattctctct taccttcttt aaaattgaat cttatatcat
    23101 caatttcttc accagctaaa agtttcttta agtctaagtt aaacttctct aaatctattg
    23161 cataaattga ttcaaaatca taatttccat attcatctaa aggagtatgt tttctatcta
    23221 taaaataatc atctaaagaa attgaaatag gatttaaatt atttactcta agatgtattg
    23281 ataatctgtg agcaaaactt gtttttccag atgaagatgg agctgctatt aaaactactc
    23341 tcttattgcc atcctttatc atatccgcta tttgagatag cttcttttca tgcaatgctt
    23401 caaatgtcct tattatatct ccatattcat tgttttctat tattttatta agagatacta
    23461 ccttgtcaat tcccataagt cttgaccatt cttctgcttc ataatataca cttgatagct
    23521 taggttgagg tacaaatttc ataggaagag tcttatcttc ttcactaggt cctaaaatta
    23581 taacgcctcc attataaagc ttaatatcaa atgattttat ataaccagtt gatggcaaca
    23641 tataaccata aaaatggtct atatagtttc tacacttata tactttagca ctatcatact
    23701 ctttgtattt caaaagctct gccttttcat acatttcatt attttcaaag atagaaatag
    23761 cttcatttct tgtaacttca attttttcta taacataatc gttgtttact atctctttca
    23821 tcttgttttt tatattttca acatctgctt ctttaagctt tctatctata tgaacttcac
    23881 aatatagccc atctgatagt gaatgttcta ttgtaactct gctatcccaa aagatttctc
    23941 tacatgccat tacaaatata aatgacatga ctctaaagta aactctctct ccatcttcat
    24001 tagtagtatc taaaaaattt atctcacaat ccttcttaac tctacaattt agctctttta
    24061 gtttattgtc tacaactgca agtgttatat aacccttatg ctcatcacaa aattcttttg
    24121 ctatatctcc caatctgatt ccaggggaat tttcttctaa tgaatattcc ttatcttttc
    24181 cttctatttt taagtttatt tttttcactt caacatctcc ttccttttga tgaatataaa
    24241 ttttaattaa tgaggcatat caacaagata aagagaggta tttaaccctc tcctacaata
    24301 ttattcaatt tacttatagt atcttcaatg tcttcgtaat ttatttctaa tactaaatat
    24361 tctgcatcta atgttaagac ctctttaatc ccctcttcag ataaaattcc tcttcctata
    24421 ccaacatgtg tatcattgat accatcatta tcacttaagt gtatcagtct tattttatcc
    24481 tttaagttct ttacataagc atcctcatca attaaacagt gtccagtatc gtaacaaaaa
    24541 caaatcttag aatttttaat cctcttaaat atatattcaa aatcataaga tatatttcca
    24601 atatttgaaa aatccccacc ttttgaataa gtattctcta tacatacata tgaatttgta
    24661 tttaatttat ctaaaaaatc cacactattt cctaaatatt tgtctctatt ctttctaact
    24721 ctatttgtca taacatatcc caaatgaagg ttaaaatacc ttaaatcaaa tccttttagt
    24781 tcaaattcta tcttctcaat aaaatttatc catgaatttc gtatatactc tatgttttcg
    24841 caagtattta attccatagg caagtgtatc cctatagata atcctaactt agaaattctc
    24901 tctttatatt tacataactc actacattca gatatattgt caattccaat ctctaaatga
    24961 gttatttgct ttatactctc acaaatgttt aaagcctcct caatattaaa caataaggac
    25021 gctataccaa ctgccataca aatcacctac tcaaaaatac ctatatctgt aaaaggaaat
    25081 actcttaaaa taacttttcc tttaatattt tcttcatcta ctaatcccac ttctttatat
    25141 ctactgtcta aactaacttc tctattgtct cccatcgcaa atacttttcc cttaggaatc
    25201 accatatcaa tatcgccttc agtataatta tcatgtatat atgaaacttc atttaataac
    25261 ttaccattta tataaacctt agaatcctta atttttagat ggtcaccagg aacacctata
    25321 acccttttta caagctcttt tttccttcca ttctcttgta ataaatcagt cttaaatatc
    25381 attatatctc cacattttgg ttctgataac ttatatgtca tcctgtttgc taccaaataa
    25441 tcatgtgatt taagtgttgg gtacattgat tctccattta ctaatgttgg ttttataaaa
    25501 cgagttataa taaatgcaaa aaaaagtgca gtaataatta tttttatcca ctctacaatc
    25561 tcttctttaa tagtttcatt cattcacaaa ttctccttta tagttatatt atctttattg
    25621 ataatgtctc ttaaacacta tcttttagat aagtctacta aataaggtgt tgtctttttt
    25681 atatagacaa ctattgtgta tggtctggtg atttcagcta atcagcgatt gctccaaatt
    25741 ttatatgttt agtcaatagt tcctatctta gaaaatggat acaatctgac tagaaccttt
    25801 cctaaaatgg tatgctcgtc gaccaatcca acctcatcgt atctactatc taaacttttt
    25861 tctctattat ctcccattgc aaataatttt ccttctggaa ctacgatatc aatatctcca
    25921 tcagtacgat tattatgtat ataggaagtc tcatctaaca acttatcatt tacatatacc
    25981 ttggagtctt gtatttttac atggtcacca ggaacaccta taactctttt tactaaatct
    26041 tttttctttc cattttcctc tgttaagtcg gttttgaata ctattatatc tttgtatttt
    26101 ggctctccta ccttgtacgc aattctgtta actatcaaat aatcacgttc aactaatgta
    26161 ggatacattg attctccttt gactattgtt ggcactataa aacgagttat tgcaaatgcc
    26221 aaaacaagag ctatgacaat cacttttatc cattctacaa cttctttttt aactgcttca
    26281 cccactaaaa tcgtctcctc tgtgttaaat attaagtcaa tctacagcaa aataatctac
    26341 cataaaccta caatataaat attatacttc ttttttctaa tagtttaaaa tacttttcta
    26401 agacctttag gataatgatt cttaattaca ccagaagatt cttttcccca acctaaaggt
    26461 attccttcaa ccgaaaccaa aacccatcct ctactatcat tagaatttac aacatcccct
    26521 tttaaatatt taagaattga ttcactctgt acactgaagt tttcaacatt ttttacatct
    26581 tcaactttta agtaatgaga tagtgcatga gaaggctcaa atctattctt ctttaaaacc
    26641 cctaaatgca aaccatatct caatactttt agttttttcg tatctggata tatttcagga
    26701 agtaggtaca aattttctcc tcttaaataa aatttatttt ttttattact ataaaaatca
    26761 acctttaaaa atttcttttc aaactcccta taatccttta tttctttatc taaatttttt
    26821 atttttaatt ctttgacatt acattcttct tcttctaatt tttttatttt ggcaacaaaa
    26881 tgaccttctc cctttatctt atgaggccat aatctttcca tttcaataag ttctgcatgt
    26941 ggatattcac tgataaactc atttataaca tgctcatttt cctcccttga aaaagtacaa
    27001 gttgagtaaa ttaaaatgcc atccttcttt aacattttat atccatctct tataatctct
    27061 ttttggatgg attgacattc tactaccttt gcataactcc aatctgatat ggcaacctca
    27121 tccttcctaa acataccttg cccagaacaa ggtgcatcta taataacctt atcaaaatac
    27181 ccattaaacg tctttcttaa gctattagaa tcggtgtttg ttataataca atttctcgct
    27241 ccaaatcgct ctaaattttc ccctagagcc ttaattctac tagcattaat ttcattagaa
    27301 accaataaac ctgtatcgtt tagcttagat agtatatatg tagattttcc accaggagca
    27361 gcacacatat cgagaacttt ttcaccctct ttaatatctg cctttggtat tacactcatt
    27421 gcagaaggct cttgcaaata gtatgctcca gcctcatgca gtggatttct accaggtctg
    27481 tcaattttat catcataata aaaaccttct tctgcccatg gtatttgatt caaatcaaac
    27541 aactccaaat caaataattt tttcttgtca atttttaaag tatttattct aagcccagta
    27601 gtcttacttt cctcataact ttttataaaa tcatcatatt catcttttag tatttcttca
    27661 atatcttcta aaaattcatt tggtaattct gtcaaatcta taatccccct tcaatctgct
    27721 ttacttgtgt gtcatttatt atactttaat tatttatgtc tttcctttaa attttatttc
    27781 ttcttctttt tcctaagatt accgaaaaac acttttttag agtgattcat atatttctca
    27841 agtttatcaa gatttatctt ccacaaaatt attacataaa ctataagtaa tataatagcc
    27901 catctatatt ctatcatcaa tatgaaatca aaaactccat gtaataaaat tggaattaac
    27961 actgccataa acaaatactc acgtctttta tttttatttc cctcaaattt atacttagaa
    28021 atatagtagc ccatagtaat tgcaaacatt acatgagctg gtatagagat aactgcccta
    28081 ttaataccaa cttgcagtgc tagatttcta ctttcagaaa aaatataaac catattttca
    28141 attgttgcaa atcctaaagc taaaaataca gagtaaataa taccatctaa cttttcagta
    28201 aagtgttttt ctttaattag ggcaggaatc agtatcagag cttttacacc ttcttctaca
    28261 agtcctgcaa ctacaaatga tacatatatt agttctgaat acccttcaaa tacattaaac
    28321 ttcatcagta aattttctaa aagtataatt ataacactta gaaaagcacc tattaaaaaa
    28381 aatttaatta gatggattag gggttctcta caatatctat ctttagacct tatccaaaac
    28441 attcctatca atataggaac tattgctaat aaaaataaat ctagcttcat agattatttt
    28501 cctttcaaaa tttttgattt atttatgatt tatatcatct acttattttt aacttattcg
    28561 tgttttaaat acatactaaa atatacatta aattatttta aattatttaa atacaaatat
    28621 actcaaatac tcaaaaaaat ttaaatttat atctatatta tttaacaaat tttaagctat
    28681 attcatatct tgaaatataa gggaactaaa ttcatttaaa gaaagggtga tttgatgcaa
    28741 gatggtttct taacagtaag cataattgat gctactaaca atagacctat tcaaaatgca
    28801 gtagtaaaca tatattcaat gtctaatggt agccaaagct catcaacttt ataccaaaac
    28861 ctaagaagta atgaatctgg tcaagtgact ggtttagtat taccagcacc agatgtagat
    28921 tactctctac aaccatctga tgttagacct tatagccagt atatagtgga agccatagca
    28981 gatggatatg agacagttgt catagaagga acacagttgt tagctacaat tgaagcaaga
    29041 caaggagttc ccatgtctcc tagaacaaga agtaagcgtt ctttctcaag acaaagtgag
    29101 ttgatttttg acataggaga acatactcta tatggtactt atcctcctaa gattccagaa
    29161 agtaacttaa aaccattacc acctcctact ggtttcgttg tattagataa ccctgtagtg
    29221 cctgaattta tagtagttca tgatggtttg ccagaagatt catcagctcc aaactattgg
    29281 attccattta aagagtacat taaaaacata gcatcatctg aaatatattc aacttggcct
    29341 gaacagacaa tttatgcaaa tgtaatagct ataatatcat ttactttaaa tagagtcttt
    29401 actgaatggt atagaaataa aggatataac tttacaataa cttcaacaac agcatacgac
    29461 cataagttta taaataatag aaacttattt gaaccaatta acgtagttgt agatgctatt
    29521 tttaatactt ttataaaaag acctcctaca tcaagacagc cactattagc acaatattgt
    29581 gatggacaaa aatcccaatg tcctgaccaa atgactcaat ggggcagtaa agacttaggt
    29641 gaccaaggat atgactatga gagtatacta agatatttct atggagatga gatagtattt
    29701 gaaagagcgc ctatagtaag tggtgtacca gtgtcattcc ctggtactac actacaagtt
    29761 ggttcttctg gacagtatgt tagaaccata caaaatcagt taaatgctat atctaattct
    29821 tatccagctg taccaaaagt tatagaagat ggtatctatg gaacagatac agaaaacgct
    29881 gttaagatat tccaaggaat ctttggttta cctcaaagcg gagtagtaga ttttaaaaca
    29941 tggtatgaaa tatccagagt ttatgtagct acaactagaa tagcttcttt aaatccttta
    30001 atttaaagct tgatttagaa cataaactca aattattgaa taaaattatt aatttaaaat
    30061 aaaaatggct gttatgaact aatatatacc ataagtatta cttataagta ttgtagtctt
    30121 aacagccatt ttttagttat aacttgtttt tttagaatct taaaacttta aatgggggat
    30181 tttaagcttc ttaaaaacag tgcttagcaa cttagatttc tttaaaatat tatatttatt
    30241 tttaagttta ataaaatgct attctaacga aaaacctact ttttatttaa aatctcactt
    30301 attatttaaa atgctacttc tcacttagag tattactcct tattatttaa aacactatct
    30361 atcacttaga gtattacttc ttattattta aaacactatc catcacttag aatattactt
    30421 cttatataaa ttattattta ttataaatac aaataatatt aatttaaaaa gttattccta
    30481 atttaaataa tactactatc ttcatcagtg aacctaaact gcaactttag acttattagc
    30541 taaagccaat attagaccta aagctataga tgcaaatgca gaagcaatta ctctatactc
    30601 agcagggaat aagaatacaa ttgtatgaca tggtatccag aaaaatggta tagtttttaa
    30661 aacactaaaa ccaaggtaag cattccagtc cacaatattt accacatctt taagttttac
    30721 cttaatcccc tttccaacct catatttttt atctataaaa cagtccataa ccttatggaa
    30781 taaaaataca gttggtgaca ttagtatatt catagttgca ctcttaaata gagcatttgc
    30841 aaaagctatt ccctcaaatg gaagcatacc atccacttgt gcttgaccta cacctgatga
    30901 gtagattgac attccatatg tggtaactac acctattatt ccccaaacta ttgctctata
    30961 aaatactcct actggtattt tccaatcctt atacaaaatt ctagcaccaa gtaaatctcc
    31021 cattgtagct aatacagcaa actttaaaaa acctccaata tatggatgtg cacctgttgc
    31081 ttccataaat acttctctac tacttggtat tgctaagaca gcaataatac aaataagaac
    31141 tccactccat ataaaatcgc cttttttcat atttataaat actatttaat atataaatag
    31201 ttctcctttc tattaaagat ttatttaatt tacaatctat ctacaattat ttattaatca
    31261 cttattatta gatattcatt ttccatattt aaatttattc tatcccttta tctatttatt
    31321 ttcttactac tctatccacc attatctata tatttatttt acgattactc tttcacccta
    31381 accctttaat tatctatttt ttctgatatt cttatctacc atcatccata tatttatttt
    31441 acgattactc tttcacccta accctttaat tatctatttt ttctgatatt cttatctacc
    31501 atcatccata tatttatttt acgattactc tttcacccta accctttaac tatctatttt
    31561 ttcttactat tcttatccac atcatccata tatttatttt acgattactc tttcactcta
    31621 accctttaac tatctatttt ttctgatatt cttatccacc atcacccata tatttatttt
    31681 acaattactc ttttacccta accctttaac tatctatttt tttctggtat tcttatctac
    31741 tattatctgt atatttattt tatgattact cttttaacct accccctata ctttatagta
    31801 atatgttttt aacctttttc attattccca atatgcttta taactacaaa tactctcccc
    31861 ccttaaaaat aataataaaa ttaatcaata aatttataat catattatta ctctatgtat
    31921 taagcaatta ctatgccaat aaactttgat ttttttaaac aaatcttaaa aatcctaaaa
    31981 tgctaatttt ctttaacttt taatgaatct aatagataac atttaatttt cgttatattt
    32041 ttcagaatat ttctattatt atttttaaga aaaaaaaata atgttaacat ttcttaacat
    32101 acattaaaaa atgttaacat tataaattgg gtttaatact tttactttga ctcgatttac
    32161 ttttattcta cttcttactt tatttttaac ttagacttta tttttttatt acttatttga
    32221 gtcttattta ttttattatc actccatatg ttcaattaca tttgtctaaa ttctttgata
    32281 cttttattac ataattttaa caagcttaag tgttatttgg gtagtgcagt tgataattat
    32341 ttaaataatc atcaactgca tgtttatatc attacagtag cttaatgtat ttaatcatac
    32401 ttacttagga ttttgaaata tcttagagat tatatttaac attagtcaat tgctgcataa
    32461 ttgtaagcaa ttgaaatttg agacccatct tcattttcta tagtgatagg cttcataatt
    32521 tttaatcctt cagtttttat cttttctaat tcttgttcca ttttcttaat tgtttcctca
    32581 aggtcttttt gacttacatc tttgactgca ttagggtctt tagcatagtc ttttaattct
    32641 tgaatatgtt tagcatactc ttcataagta taatgctcaa caccatactt ttccaattca
    32701 gtagggtcag ttattcctga ttttattaga gattcaagtt taggtaaagc aatattagat
    32761 gaatcatttc catttgcaaa tactgctcca gttcctccta gtaccattgc agataccatc
    32821 attgcactta taagggattt ttttattttc ataaccaatc ttcctttctt agagatttat
    32881 ttgggtagtg tagtttgaaa tgactattgc aatagttatc aaccacatcc ttagactatc
    32941 acagtagtca tgtttatgtc aagccttttt aaaaaacttt tcaataaaaa atactatctc
    33001 aaaacaaaat taattatttt gagatagtat tttaattcta aatcttttat attactaaga
    33061 tttatggtta ctctatccat gttctatatt gttctttatt aactgctaac aaattccctt
    33121 ttcttgatat gacaaagcga ttatcattat agccactttg ctcaattgaa acttctcctg
    33181 aatcagtata aagtacatcc ttaccattac tagatttatt tacatacgtt tcttcgctat
    33241 tctcagaatt agttactttg ctcatagatg attcttcatg ctctctaaat tcaattacag
    33301 atacttttgc cgtactaaaa tgagtctctc catcactttt agctttacta acaagaatat
    33361 cagattctac tttgggagaa tataaatcag ttgatttact acttattgaa aatccaattt
    33421 tatcactttg ttcatttttt gttaaaccaa aagattcaac ctcattaatc tctttatttt
    33481 ctgttgcaaa aacaagacct gtcccacaaa ctaatacagt tgaaactaaa aaagtaacat
    33541 aagttgattt tttaaatttc ataatattaa ctattctctt ttctattttt gtctttccaa
    33601 atccactaca tattgtcatt gaaaatggat tattctcctc tgctagactt attagtgtgg
    33661 ttgcataatc agccctatat tcttcaccaa gtatactcat aaccttttca tcacaactaa
    33721 attctatgtc tttatttagt aaaaaaaaca tcacccaaac taagggatta aaccaatgga
    33781 caacaagagc tacaagcata aataacttta acagattatc aaagctatta atatgaacca
    33841 tttcatgagt taaaacaaag tctaaagttt gattattagc ataattcatt tgctttggca
    33901 aaataattcg tggttttaaa ataccagatg taagtggtgt cctagtaaat tcagatatgc
    33961 aaacaataaa tcttctaaaa cggctattct tacacatcca ttttttaatg aactcatgat
    34021 tttttatatg aattgaagtt ttaaaaagat taattatttt aaaatatcta aagcataaaa
    34081 gtatgctaaa cataatagta actataaaag acaaaatgcc caacatttcc aacatcataa
    34141 tattttcaat attagacatt atttcaaatt cgtcagaatt gtttttacct gtagagtcac
    34201 tagctttctt aagagtataa ttttctgttg atgtattacc caattccaca tcaaaagtcg
    34261 attcaattat actataaata ctaaaaccag aatttaaact tactggtatt agaagtttaa
    34321 ataaaacaat caaccacaat aatacaaata cctttttagg taatttttta aataaacatg
    34381 ctcttataaa aataactatt aaaagtaata ctccagaagt aaaactcatt tctaacaatt
    34441 taatgaacat aaatcttacc tcactttaat ttttcaacaa tttgtttaag ttttgtaatc
    34501 tcatcacttg aaagattttc tttattaata aaagctgaaa gaaatttttc tgaagaccct
    34561 ccaaacattt tattaattaa agtttctgtt tcctgttttt gtacttcctc tttgcttatt
    34621 aaagctttac aaacaaaatt cggctcaatt ctctctattg caccttttga cactaatttt
    34681 tttataacgg tatacgtagt gtttctattc catcctgttt cttcttttaa aatttttact
    34741 aactctccag ccttgctttc tcctctctcc catagaactt ccattacttt aagttctgaa
    34801 tcaaataatt ttatctccat ataaaatcgc tcctcaaata tagttatcac aatagtcatt
    34861 actataataa aaaactatca tagtagtcta tactatgtca atcatttatt ttttaataat
    34921 aaaaactgtc tttttaaaaa attcttataa aagacagttt tatcaatgtt atactttaat
    34981 ctttaattaa agccatattt tatttaaata tataactata tatcttagta catagtataa
    35041 gatttttctt tatctaatag tatatcctct acatctgggt tttcttttac taattgtcta
    35101 taaaaattac aattagtaac acctacatat ggaattagcc atagtagacc tattccaaga
    35161 gtagctattg aaagtatata ccatcctata aaactaaagt ttagtacaaa taatttaagt
    35221 acatttcctt tcatcatatc taaactagca cccattgatt taaatacacc catattatcc
    35281 ttgtcttcac aaattaagaa agtagcttga gaaacatata atagcaatat ataaaccggt
    35341 aacataagaa caagtattat aagaactaga gttattccag tagaaataac agtccctatt
    35401 ccaacattat cacttgataa atattcaatt gctccactag taagtaaaac tccaaatgat
    35461 aaaaacgctc ctataattgt gattataaaa gaataaatat aaacaataat tgattcaaat
    35521 aaataaaaac caaaacttct taaataaatt ctcccactta caaagatatc tcctatcttg
    35581 actttttcat ctttagtaat tttcaagaac atacatgtaa atcctgctga aacgcaaaaa
    35641 gctattacag ccactacaat agtagtcaat ggttcaaaag gtaatcctac aattgatatt
    35701 aatactatca atgcaatata tactgccata gaaattgcac atatccccca gtttccagat
    35761 aactgagctt tagatactcg ttttaattct tgccttgata ccataaaaaa cacccctttc
    35821 attttataaa aaaactttta aaaatataaa taatctttta acgtataata ttaatatatc
    35881 atattttcga ctatataaga tacaattatt caccatgttt tatcaagata taccataatt
    35941 gtattactag ttttatatag tcaacattac caaatacatc aaataaattt gattaattat
    36001 tcaacaagta ataaaataat ttctattaat tatactttat ttagtaaaca aattatttaa
    36061 taaaaaaatt acctaataca gtaaattaat tggtaagata aattatttat tattagtaaa
    36121 gtaaattatt tactatttat caagataaat tatttataaa ataaatcatt tataaaatat
    36181 aatttatact ttgaaaataa aataaactat cttccaaaca ttttattata tgcttaaaag
    36241 atagttttgt gtctttaaaa taaattaaat tgtatatatt ccttcacata acttttgtat
    36301 attactaggt ggttgccatt taccatcttt tttagtatat gtaatcatag ttgtaacttc
    36361 cttagttggt ttcttattgt aaaggtctat aatcattttt gtcatatcat cttgaacttc
    36421 tttttctttt ttatcgtaat tcttttcatc agttacataa gattttacta aagtgttcgc
    36481 ttcactcatt actttactag tatctaaagc tttacttaca actttcaaag ttatcttatc
    36541 cttactagaa gattccactg ttactgtctt ttcaacacct tgaattaatt taacaattgt
    36601 ttcgtatatc ttttcagcat tttctttacc ataaagaggt gtcaattgag caatcattga
    36661 aaccttgtcc ttgctgttat aagtttgaat ctgtttatat tcagcttctg ttaatgcatc
    36721 agaaattcct ttttcatcat acttatacat ttctaatgca gctaaattag cttcaaaatt
    36781 cgactttact ttttcttctg cattagaaca ccctatagtt agaactaaaa ctagagccat
    36841 aatcgtagat aatattaact tttttaccat tttcatacaa acatcctccc tcaattaaaa
    36901 taataaaaaa tttatttatc aacattataa cataaatttg tctaactata gaattatttt
    36961 gaatatttta ccacttccag tctattccaa taccgttttc ttttgcttta tcgtatattc
    37021 tttttgctgt tacgacatct tgtacaccta tcccaacagt tttaaataca attatctcat
    37081 catcatcttc tcttccagga atagttccgt ttataacatt ccctaaatca ccactaaaat
    37141 catctttact tatcttacct tcttttaatg gaattaatat atctcctgac tcagataaaa
    37201 ctgcatctgt tgattcaaaa aatatcttag acgctctagt taaacagttt gggcacaact
    37261 cttgcatatc tggcatatat gaacctactg cacttattaa agctcctttt ttcactaagt
    37321 ttccattaag tactggttgt tttgatggag tagctaaaac tatcacatct gcgttattta
    37381 tggcttcatc agatgattca actgcaacta ttttagtatt atatttactt aattttaagt
    37441 tcatttcttc tgcaaatttt tctctacttt ccttgtttct actaaaaact cttacctcat
    37501 ccaaatttct agcttctatc atggcttcaa gttgtggctc accttgtcct cctagaccta
    37561 tcaaagctcc aatcttagaa tcttttttag ccaatacgtc tatagctgct ccagaggctg
    37621 ctccagtacg aatctgagtt acataagtgc catccaatac tgcactaact tctccagttt
    37681 ctccatctaa taatagtact gttgctggaa ttactggttt gcctttttga gcatttttag
    37741 gaaatacaga tacaattttt attcccccac agcctaattc ttctatgtat cctggcataa
    37801 ataacatact agcatcttga cttggaacag atatattggt tctcaaagga tttacactct
    37861 ttccttcaca ataaattcta aaagcttcct tatcagcttc aattgcatct ctcattgtaa
    37921 atactttttt tatgtcgtct ttttttaaaa gtagcatttt tataccccca attttaataa
    37981 gtctctatgc taaatattat agcataacat ttaatttaat cttctatttc aaatcaaata
    38041 aatctacata ctctggtttt agcatagaac ttatcaacgc tttatttatt gaaaattctg
    38101 gtattcctgc tgcatatgga gttatatcat ataaatcaaa atatacaact agattctcat
    38161 cttgcaaata aaagttttga ttctctttta tacctttaaa attatatatt ccgatatttt
    38221 cttcatcctt tttttcaagt tcagctattt gtcttttaat ttcttcatct ataacttctt
    38281 tatatttagt attatcctta aacaagtcca ttaattctaa aaattttcca gttctcatat
    38341 ccacattata tgctatatct tgataaaatc catgtgctcc accactataa gtataatatc
    38401 tcacttttat actaagagca gaatcagtat tctttttaag ttcaaagtct acatttgcaa
    38461 caaacttatt tttctcgtca ggattatcct taagatactg ctttgcttct ttatatgatt
    38521 tattataaaa ttcaaatatg tcatttttta tcttatcatt tgtagacctt tcaacaattt
    38581 tatttgaatt tgttattaca ggcatgttta tagtactttc taaatactca tcatttttca
    38641 ctattgtttt acttcctatt gtacttactg ataaagtttg tttactattt gtattaccct
    38701 ttggtaatga ctggttactc ataacagtca ctgcttcctt attactattt aaattaattg
    38761 aagcatcttt ccttaaatta ttatatttat agtcatgttt aattgccaaa acagccatta
    38821 tagtcaatgt taaaacaaat acatatctta aaactttagc ttttgtatcg actttaaaaa
    38881 atttcatatt atcattttcc tcctaaatat aaatctctct tattatattt ggagtttcta
    38941 gggtttttta tccatataat ttaataaaag attaattttt atttataaaa aattaatctt
    39001 tttgttttaa aatattaata tgtcttatca aacagtttga aatttcacca agaggtaatt
    39061 gtaacataac agaacctcta tcaaaagcta ccattggcat tccatatact atacaagaat
    39121 tttcatcctg tccaattgta aatgaaccat tttctttcat ttttaaaagt ccatttgctc
    39181 catcataacc catacctgta agtattattc ctattgaatt tttacctgct acttctgcta
    39241 ctgaatcaaa caaaacgtct actgatggac agtgaccact tattctttct cccttttcac
    39301 aagttacata atatccttgt ttatctgtac acaatttcat ctggtaaccc ccaggtgcaa
    39361 ttaacacatt tccttgttcg actctatcat tattcttagc ttctcttaca ttcataatac
    39421 actgcttgtc aagccgttgt gcatacatat aagtaaatat agctggcata tgttgaacta
    39481 caacaatccc tggtgttgat tttggtaggt cttttataat ttcaagtatt gcttctgtac
    39541 cacctacaga tgcgcctata gcaataacca tattattaaa acgttccaca ttaccgcctc
    39601 caaaaaatca tatatcaaaa ataccttttt atcgtttata tatagcaggt tttacatatt
    39661 tgtatttagt actacttctg ttgattactt ctgcatgtcc tacaaacaaa aaactatctt
    39721 ttttggtagc attataaaat ttatttataa gttcttctct tgtttttaaa tcaaaataaa
    39781 tcataacatt tctacaaaaa atcaaatcaa aatgttgata tgagaaatca ttcattaaat
    39841 taaacggctt aaaaattaca ctttttctaa tcttatcaca aattttaaat gtaccatcct
    39901 tgttgtctat aaaatacttc ttcttccata actcaggaac attgttaaca tttgattcta
    39961 tgtatatacc tcttttagct ttttcaagtg agttagttga aatatctgtg gctatgattt
    40021 taatgttcca caactcttta ttatatccaa aataatcatc caaagtcata gctattgaat
    40081 acgcttcttc tccactagaa catcctgcac tccatatatt tatgtttctt attttattat
    40141 tttcttccca aaaaggaagt atactattct gtataaactc aaaatgttga ggttctctca
    40201 taaaaaatgt gtggttagta ctcaatctat ttattaggtt tatagcttca tttcctgtct
    40261 tatctttaaa taatagattc atatattgac taaaagaact aagttttttc tctatcattg
    40321 tattgtataa gcgaccttca attaacgctc tttttttact taaatcaata ccatattctt
    40381 tttttacata gtttacaaga actataaatt cttcatctgt gagttttatc atgcaaaaac
    40441 ttcctcctgc taatttatca gaactaacta tatgctatta atcaaaaact ttcgaatatc
    40501 taaaattaat atagaattat cttcaacttt cgcaatctct tttatatctt tattaatatt
    40561 agtgttgtta gaattagtcg tctctagtaa atttagattt tctatatgaa taacatcaac
    40621 aactttatct acaataattc caacttgata ctcatcaacc tttgtaatta ttatacaagt
    40681 tctctcatta taatcagctt taggaagatt gtactttata tgcatattaa taactggtat
    40741 tattcttcct ctcaaattaa taactccact tatatatgtt ggaagacatg gtacatacgt
    40801 tattgattga aatcttatgg tttcaatcac attttctaat tctattccat aaataacatc
    40861 attgacataa aatgttaata cttgtttaat aatttcatct ttagccatac tttaaatccc
    40921 ctaatatatt tctataatgc tatctgcatc tataattaaa cttatacttc catccccaag
    40981 tattgtacat cccgataaac ccttattttt tatattaaat cggttaaaat aaactggaaa
    41041 tggtttcaca acaacttgct gattacctat tatttcatca acaaaaatgc atactgcttt
    41101 atgctcattt tcaataatta tcatattacc attcatcaga ttggttactt ttgtttgaat
    41161 attatatatt ttatgtaacc ttataatggg aatacatgct ccatatattg taattaactc
    41221 tgtcttattt ccttctgtaa ttatttgatt taagtctgta agtttaaatg ttcttcttat
    41281 ggatgatatt ggtaaagtaa atagtgaatc tccaacttta aacttcatac cctctactat
    41341 agaaagagtt aatggtattt ttatagtaaa ggttgtccct tcatcttgtt tactttttac
    41401 ttcaattgaa cctccaactt tttcaatact tttacgaaca atgtccatgc ctactcctct
    41461 tccagaaaat tcagttatag attcttttgt agaaaagcct ggagtcataa tcaaagaatt
    41521 gacctcgtca tcagtatact cattactttg atgtttaaga agaccttgtt ccttagcttt
    41581 tgccaaaatc ttatctctca taatgcctct accatcatct gaaatactta tcacagcttc
    41641 tccgcctaga ttttcagcag ataaaactat ctttcccact tcttctttac ctttcgctat
    41701 acgctcctca ataggctcta ttgcatggtc catagcattt cttataaggt gcataaaagg
    41761 ttctgctaaa ttatcaatta cactcttatc tacctctgtc tctgctccta tagttattaa
    41821 ctctacattt ttatctaatt ttttattcat atctcgtaca attctatgca ttttttgaaa
    41881 tacaccagca atttgaatca tacgcataga cattactata tcttgcaatt catctgtaag
    41941 cttgtgtaat tgtcttgttg ccttattgaa attatctata tcaacacctg tagaatttac
    42001 gctatttaca accattgatt ccataattac aatttctcca actatatttt gaagtaagtc
    42061 caatttttct aaatttacac tcataatact ctgcttactt attggtaaat gttcattttc
    42121 ttcacttaga ctatcttttt ccatatcagt tttttcattt aaaacatctt cttgtatctc
    42181 atcttctgta tagttatttt gataactttt acttacttta ttattatctt ttaatttatt
    42241 ttctactgca tcattgtttg atgtattttt catttctatt tcttttttac taatatttat
    42301 gtattctttt acatagagat tatcttctat agttttataa actattgcct tatcctcttt
    42361 agctacaaat tgtatataaa acccataact tttaatatac tctgtagact ctgcatttgt
    42421 ttctacatct tttggataaa aatctataaa ttcacagtaa tctctaagtt caaatacaag
    42481 catgaaagct ctcacatttt ccatcatgca accttgttca aagattattt ttactacatc
    42541 agagtcttct ttgtattcaa aatttgaatc gattacttct ttttcgtctt tactttctaa
    42601 atttgcatta tcctttgatt tcatagaact tgataattcc aaagtactca catactcttc
    42661 aattccttca ataaaattag agtaatcaga agatatacaa cctcttgatt gtaactcatc
    42721 tatatctctt cttataaaat ctaatgattg aaagactaaa tcaaataata ggtcattgtc
    42781 taaaacttct attttacctt cacgtatagc ataaaacaag tcttctacac tatgtgctaa
    42841 agcagatata ttgtctaacc ccatcataga tgctgaacct tttatcgtat gcattattct
    42901 aaaagtttca ttaatgttgt tatgagtaaa tactttctct ttttctattt gaatcataat
    42961 ttcatctaat tgttcgagta ataaacttgt ctcaaatata aacatatcta acatttgtct
    43021 catactcggt tcaatataat tcacatttat cacctacgac ctacaaataa ttttctatta
    43081 tatatgcatc tcataattta aatccttgat gattctctta tctcactata tgtacctcat
    43141 aatttaaata cacaattatt ctcttacttc aatatatata catctcataa tttaaataca
    43201 tgataattct cttatttcaa tatatataca tctcataatt taaatacatg ataattctct
    43261 tacttcaata ttcacctcat aatttaaacc catgatgatt ctcttacttc actttccttt
    43321 agatgaaatt tttctactaa ttcttttaaa atttgagctt gagcagacat ctcttctgag
    43381 gctgctgcac tttcctctgc tgttgctgag ttcatttgga ctactatgga aatttgctct
    43441 attccagata aaatctgtgt aattgctact tcttgactat gtacagccga agaaatacca
    43501 ttaatataat tagtagtttt ttctacacca tttactacca agtccaatgc atttgcagtc
    43561 tctttagcaa ttctgacacc attttctact gttttaatag cttcttctat gagaatagct
    43621 gtattttgag ctgcttttgc acttttacca gccaaagacc taacttcatc tgctacaact
    43681 gcaaatcctc taccatattg acctgctctt gctgcttcaa cagctgcatt taatgcaaga
    43741 atattagttt ggaatgctat ctcatctatt gttttgatta tttttgatat ttcactcgat
    43801 ttttcactta tttcacccat tgatgtcatc atatcatcca tacatctact tccaaaacca
    43861 acttgtgatg cagattggtc agatacctca catgcaagac tagcactatc tgcacacttc
    43921 ttaattccat ctgatatctc attaatcgtg gaagctaatt cttctactga actagcttgt
    43981 tcagtagcac cctgtgaaag agcttgtgca cctgctgcaa cttgttctga agcacttgca
    44041 acttgctctg ctgataaatt tatttcagaa aaatcaccat taaaagagtt tattatactt
    44101 tctaaagata ttttaattga tttaaaatca cctataaatt cttggtctat ctctactctt
    44161 aaatctcctt ttgcaatact agttaatgta ctgtctataa ggtctatgta atttaaaagc
    44221 atactttgca tctttttgac agaactcact aatagcccta tttcagattt actttcttca
    44281 acgtctatac ttgttcttaa gtccccagat gcaattcttg aaaagtgttt ttctacttta
    44341 ttaataggaa tcactatttt taattttatt actgtatatt ctattattgt caatattatt
    44401 aaaagggaaa gtataaatat tgttcttaat attagacttt gtaattcttt ttttacctct
    44461 acaattttgg aatttgaacg ggtaactata tcctcttgaa attcatttat taaagaatcc
    44521 attttctctt gggagtttat atagtcacta ccaaaaatta tactttgagc tttactctta
    44581 tcattacttt cgactgcctt tattgcactt tgttctgttg gtactaaaga atctgatatt
    44641 tcttttgctt ctaagatttt atttgactcg ctctttgtaa gaccaatttt ttctaatttg
    44701 tttaaagctg attctcttgt ttttccgtat aattcttttt cataaatatc tttattcttt
    44761 ttttctcctg taaatacata tcttcttaat acatcactta tctctctagt tgtatctttt
    44821 atatactgac tttgagtcct caaattattc atatcattaa tacttttttc tactttttca
    44881 aatgctttat aagatgaaat agaagaaaaa atccctgcta gaacagccaa tactataata
    44941 atcagcaata caattgctaa tttagaaagc tttacttctc ttttcatatc tgtactcctt
    45001 cataaagtaa gtttatatct tttttaatcc tttcattgta ctcactacgc tacaatcttt
    45061 tcctaagttt ttaccctcat acattgcttt atctgctaag gatatgtttt cttctaatga
    45121 tatatttgag tttacttcta ctactcctaa tgtaatagtg cactttattt tatgttcttt
    45181 atagttgaaa tcaaactcct ttatctcttt acggattctt tctgaaagta tcttagcacc
    45241 ttctattgga gtatttgtga gcattatcaa aaactcttct ccaccccatc ttgatacagt
    45301 atcaatttgt ctacaattct tttttattat acttgatatt actgttaaca cgaaatcccc
    45361 tgcttcatgc ccataagtat cattgataac cttaaagtca tcaatatcac caaggataag
    45421 ggatattgat gtttcactat atttattaat tcttctttgc tccataagct gattaattat
    45481 atgtcgccta ttgtaaagac ctgtaagata atctcttaca acgagtctat tcaatttttc
    45541 aagagaagat tccagttcat tatttatctt ttttaattta tcttgagatt tctttacttc
    45601 aagatgagct ataacacgag cttttaattc tgtcatacta aaaggtttca ccatatagtc
    45661 aattgctcct acaccaaatc cttttactat gtctgtatct gtattttttg aagttataaa
    45721 aattataggt atatctgctg tacgagcatt agattttact tccttacaaa actcaaaacc
    45781 agagttatct ggtaaaatta tatcaagcaa aataatgtct ggtataaatt cttcaataaa
    45841 ttcttttgcc tctattgcat taaatgcttt tttaacctta aaattatctt ttgtaagtgt
    45901 tttatctatt aagtcacaca tcagaacact atcatcaacg actaaaattg ttccctgttg
    45961 cttatttttc atatacaaac ctctcttaaa cataatatat tcaaatttta atgatttaaa
    46021 atttttatac ttaataatta taccactata ttcttaaatg ttctcatcac aatcttttta
    46081 taataacact ccaactacat ccctatgtta catgatagtg caatcaaacc cattgattaa
    46141 ttcatctatt aaaacttcat ctttatctgt caaaagtttc tctaaatcta gtaaagtaat
    46201 tattttacct tctaattctc caactccact tacaaaataa tccgaatatt ctatagtaac
    46261 tcttggtgga ggtgatattt tacttttttc taagcttact atatcatcaa ctctatcaac
    46321 cacaaatcca actaccaagt cctttatttc agttactact atatacatgc aatttgtagt
    46381 cattaattca tcttttttaa gtctcaaacg catgtctatt atcggaatga tttttcctct
    46441 tagatttatt atgcctttag aatatgtagg tagttctgga ataaatataa tttcttgatt
    46501 tccagtaatt tctattacct tttcaagttc aaccccaaag tcttgctcat ctactctaaa
    46561 ctttagatac ttaattcctt catcaattag tccataatct aaatatgggt catctggaaa
    46621 tctcatttaa tacctccctc ctaaaataca ctttctatga aatatatatt ataatttctt
    46681 cttaccttta tttattgaat ctacaagtaa ttcacccgtc tcagtgtaaa aacgtattgt
    46741 tctaccataa ttcatacctg tgtcctcagc taatattgga atatttaatc ctaaaagagt
    46801 tttttttact gcctcaacat tcctatgtcc tatacttgca attactgaat tgctacttcc
    46861 taaaaacatc tgagcacctc cagcaatttt tgcttttata tatattctat ttgcacctat
    46921 attctccata gatttaatga gctcatttat tcctgtgtca gcaaatttac acttattttc
    46981 aatgttaata gcatctttac tatatggcaa cataacgtgt aacattccac caattccagc
    47041 tactttatct atcaaacata ctcctacaca agaaccaagt gcataagtaa ctaaaacatt
    47101 tggtctatag gctatcttca tatctgcaat gttcactact atctctctat tcatacttct
    47161 aatcccaacc tcacgagtat ttctctaagt gagctcattt ctggaatcat caaaatgtga
    47221 ctagtaaaat aattatcact cattttaaat ttattttcta taaataagac tttgtcacca
    47281 acatctgaaa atcttatcat aggtacattt agaacagctc caaccatatc aatacatata
    47341 tctggaattg aaacacttat agtcatgttt aacatagatg caatagcatt tacatatgaa
    47401 cttgccataa tatttcctat ttccttaatt gctgaaattt caattgcctc aatctcatct
    47461 aaaaaagctt cttctttatt aaaaagagaa cttagcataa gttgagttat tgattcatcc
    47521 aacaaaaaca taaacattcc attgatatca cctttcatat cgagtaaaat acatactact
    47581 ttgttttctg gaccaccaag caaatttgtc gcttcattat attcaagtat cttgaccata
    47641 ggtattaata cttctacatt gctatttatc atggatgcaa gtgcagtaat tgcattccca
    47701 gagcctatat taccaatttc tctaagagca tctatatgaa catcatcaag ttctaaataa
    47761 tttataatat aaacccctcc ctttattatt gcatttattt gcttttcatt gtattagtgt
    47821 atatttacac ttttatttta aagcattatc tacaacttta actaatgttt ctgttttgaa
    47881 gggcttcact ataaaatcta acgctccaag ttttatggct tctacaatca tattctcttg
    47941 tcctattgca gagcacatta caaccttagc acttgaatcc aactttttta tttctcttag
    48001 cacctctaaa ccatcttttt ttggcattgt aatatcaagc aacatcaaat caggcttttc
    48061 atatttaaat atattacacg cttcttctcc atcatttgct tctattaaat tattatagcc
    48121 acttttactc agagcttctt taattatcat tctcataaaa atagcatcat ctactatcaa
    48181 aattttattt tccataaaac taactcctcc atatgtacaa caataaacgc ttttatcttc
    48241 agttattgtc tatactatct gactattttt cgctacacaa taaatacatt tcattgataa
    48301 ataaaagtaa ttatttatgc catattatac ttaattctct taacataatt tgtcaacaaa
    48361 aaaacttata tatctattgt aatatatgtt tggcgttttg acgagttatt aaaaatataa
    48421 ttgtataaaa cataaaaagt tatcaaaagt aattaaatta taataaaaca actttatacc
    48481 ttttttatgt ttgtataaaa aaatttttca gattcattaa aatcatttct gtagattcat
    48541 ataggatttg actttctcaa tatctaatag atagttgttt atttacttaa ttatatttct
    48601 ctatatgtat tatcgattaa attagattta gctttataca ttatttttta tatttttcaa
    48661 attgtatact cataaatcca gaagtattct aatgtgttta taatactttt tttcatattt
    48721 taaattaaat aacaaatcat tatatttaca agtatcattt atcaataaac aatattaaat
    48781 gaagaatatg tctgaagatt caaagtgata ctgataatat taattactaa aaaagcagta
    48841 aatcttttac agatttactg cttatagtta taaataataa aactatctat aataaatgta
    48901 ctatactcaa tacttcattc aatatagtaa taacaaatct actttattcc tatataaata
    48961 tgaacttctt gtttctttgt atcaaaagta ttacattgat actcttcaaa atcacttata
    49021 taagtcctat caaaatccat ttgccaaaac tcaaaccaaa aatctcctac ttctttttga
    49081 cctcctacta taacaaactt tgcatactta cctgctggta taactttact aataatactt
    49141 tctccaacag tattattagt gtttaattct tctaaattct tctctttatc agaattacta
    49201 tttacttcac aacatgcaac aaagctatac ggacttgtaa aatcaccctg gtaatctgta
    49261 tatagaccta ttgtcttgtc attcttttta ccctttatag cattatatat ccctttgccc
    49321 ataaattttt tccacaattc acctatatca tttaccgctt gtccatcttt atttgtagtc
    49381 tccttcgata ttcctataac tattttctca tttatctcta ctatttcata attcatactt
    49441 tatacctcac tttgttttta ttaatatatt ttattttgaa ctaattcaat tataatttat
    49501 aatatacgac acctttatgt catattttta atataattaa actcagtgag atattatata
    49561 ctaaatgcaa gatattatat atttaataaa atctttaatc tagcattata ttataatgaa
    49621 taaattttag acaactccct tagtctagtt attacattat ccctaacatc tttaggttca
    49681 agtacttcaa cattgtcacc aaatgataaa atatatccat aaatccattc accaatagga
    49741 aattctgtaa ttacatcata tgtatcatct tcatttttag ttattaaatc cttattaaaa
    49801 tcatcaaata ctctaaaaag catcttttct ttaaacctca atttcaacgt tatagtattt
    49861 tccttaatta ctttagaatc attcaaacat acttcttcta ttatctttct tgaaaatact
    49921 tcatccttta tagataaatt ccttatccta ctaattctaa atatcctaaa atcatctttt
    49981 agtttacaaa atccatacaa gtaccaagtc ttactcttat acataagctt cagtggttcg
    50041 acagttctgt ttgtctggct tgacaaacta tttacataat taaaatttat agtattacgc
    50101 cttaaaatag cttcttttat ttttgtaaat ttatcatctt cattaaaatt acttccccat
    50161 tcagtaaagt ctatttcaat ccagtttgaa aaattctgct ctccaaatat tgagccaatt
    50221 ttatttacta ctgaatttat ttctggatac ttagtcgcct gtaatgtttt cagtgccact
    50281 attaaactct ctttatcttt ttttgacaat atagccttgt ctatagaata ttcttctatt
    50341 aaagatatcc ctcctccttt gcctttcgtc atatatactg gtactcccga catagacaga
    50401 gtttctatat ctctatatat ggttcttgta gaaacttcaa atctatctgc caactcttta
    50461 gctgttacta attttttatt taatagaatt actattattt ctgttaatct atttattttc
    50521 attcattacc acctactaaa attattaaat ttatttaatc taaattaatc atactaattt
    50581 ttaaataaat aaaatcttag aatcttatct aaattattct tacatgattt tatttacttt
    50641 ctattatctt tctcactttg gatattatca tcttaattta tttattacta tatcaattta
    50701 cttattatca tctcatttgt tatcgtctta cttaatttac ttatttctat atcaattcac
    50761 ttattattac ctcacttgtt atcatcttac ttaatttact tatttctata tcaatttact
    50821 tattatcatc tcatttgtta tcgtcttact taatttactt attgctatgt caattcattt
    50881 attattatct cacttgttat cgtcttattt aatttactta tttctatatc aattcactta
    50941 ttatcatctt aattcatttg attattatca tttactttat tcaatttcta tatcaaaaat
    51001 tagtatttgt acttaatact taaaattaat ttaaagtctt tacatattat ttatttttta
    51061 ttgtaatatt aatttccata ctttgctaag ctacttccac tcatttattt taaaatttca
    51121 atttactatt tctcaattct atattattat ttttcaattt tatattacta attttaaagc
    51181 tttttagcta ttattcctac aatatttaaa caatttttta ataataaagc tatattacaa
    51241 tatattcaaa atatgtaata ttttagatat ttttcgttga caatgttaaa tttttgtttt
    51301 atccttaatt aaggacatgt tattgacatt tctgaaactt atttgaaata gttttttcat
    51361 tttatttagg aaaacgtatt atacctaaga aaacgtattt tctcatttca gataagtaaa
    51421 atatttattc ttttggggag gaaatcatgg aaattaataa aaaacatttt attcaagtat
    51481 ttttaacttg cttaatcttg gtagtaatat gtgaatttat agggcaaaga actatagcta
    51541 ttggaaaagc ctctatagta ctgttcccta tgctttatgc agttataatt ggacttataa
    51601 taacaccaga tttattaggt aaaaaaatta aagcacttaa aaaagtggtt ggagaaaaag
    51661 aaataaatat tgctggtgaa gttgttggaa ttgcactagt aatgcttggt ataaaatatg
    51721 gtactacagt tggaccaaac attgacaaaa taattcaagc tggaccagca tttatcgctc
    51781 aagaatttgg tcatatactt gcaccaatcg ttgcattacc tcttgcatta atgtttggaa
    51841 tgaaaagaga agctgttgga gctactgcaa gtataagtcg tgaaccttct ttaggagtta
    51901 tatcagaaaa atatgggata aactcaccag aaggtagtgg tgtacttggt acatatttaa
    51961 tgggaacagt tcttggtact atatacttta gtgtactagg ttcaatatct atttatagtg
    52021 gtcttcaccc atatgctttg ggaatggcct gtggtgttgg tagtggaagt atgatgacag
    52081 cagctgctgg ttcattatct accatggtac cacctgaaat ggcagataca atacttgcct
    52141 atgctgcaac aagcaatatg atgtctagta taacaggaat tatattctta gtttttgtat
    52201 ccttaccatt tactaatttt atgtataaga ttttagaacc taaattttcg agaaataaaa
    52261 aaactaaaga aattaaatct acagaaggag agtgctaata aatgtttgct aatttaaatt
    52321 taaagaaaag ttcatatcaa ttattggtta tgtctgttat tggagttata attcttatag
    52381 gacaaagaat tagcgttggt acatctatag ttacagctct tcctggtatg gtgatgctaa
    52441 tattagctgc tatggcagct atgattataa aagatttatt tcctaaatca atctttccag
    52501 cttttggatt tgcaactata atcggccttt tacttagtat gccatatagt ccaacatctg
    52561 aagtattctt aactaacact aataatatta actttatggc tataactact ccactactag
    52621 cttttgcagg aatttctgtt ggaaacaaaa tagaagcttt aaaagaaatg tcatggaaaa
    52681 tagttataat ttcacttatt gtatttacaa ctatattctt tgcatgtgcg agtatagctc
    52741 atatagtttt aagtattcaa ggtaaaatat aggaggaatt tattatgaat aaagaacaat
    52801 taaaatctct agtaataaaa actatagatg aaaatagaga aaaaatatta aaaataggtc
    52861 aaggaatata caaaaatcca gaatatggat ataaagaatt taaaactaca gaagctgttt
    52921 caaacttttt tgagcaagaa ttaaatttat ctgtagaaaa aaatatagca gttacaggat
    52981 gcaaagcaga tgcaaattct agcaagaaag gtcctcatat atctatactt ggagaattgg
    53041 atggtatatc atgtaaagaa cataaagatg ctaatgaaat aggtgcttct catacttgtg
    53101 gacataatat tcaaatagct ggaatgttag gtgctgctgt tggtttagta aaaagtggcg
    53161 ttttagaaca tttagatggt aaagtatctt ttatggctac tcctgctgaa gagtttattg
    53221 agttggaata cagagagcaa ttaaaaaaag aaggaaaaat aacttatttt ggtggaaaac
    53281 aagaattaat aaaaagaggt tattttgatg atatagacat atctatgatg tttcatgctt
    53341 ctgatttagg agaagataag gctctagttg gtcctgagag taatggattt gttggaaaaa
    53401 aggttaaatt tataggtaaa gaatctcatg ctggttctgc tccacatgat ggaataaatg
    53461 ctttaaatgc agcaatgctt gctataaaca acgtgaatgc acttagagaa acttttaaag
    53521 agtctgaaag agttagattc caccctatca tcacaaaagg tggagatata gtaaatgttg
    53581 ttcctgctga tgttcatatg gaatcatatg ttagagctag aactataaat ggtatgattg
    53641 atgctaatga aagaataaat aaggctttga tggctggtgg aatggcagtt ggagctgatg
    53701 ttgagataac tgaaattcct ggatatcttc caatattacg atacaaaagt cttgataatt
    53761 tatttaaaaa caatcttgaa gatttaggtc taaaaggaaa agttattgat ggtggagatt
    53821 ttacaggctc ttttgatttt ggagatgtgt ctcatataat gcctactctt caccctatga
    53881 ttggtggtgt aaaaggagct cttcatacaa gagattttga aatagttgat gaagatttag
    53941 cttacataat tcctgctaaa gcaatggcac ttacagttgt agaccttctt tttgataatg
    54001 ctaaggatgc taaagatata ttagatacct ttactccagt tatgactaaa gaagaatatc
    54061 taacattctt agaaaaacac gataaaactt tataagtcta tttttataat agggtggtat
    54121 ctactgtaaa agttatacca ctctttgttt ttgtaacagt atacttcttt tcttttagtt
    54181 tttagattaa actaagatat attatcctcc ttaaaacttt tagagctacg ttgaaatatc
    54241 agtagaacta tgctatattc tttctaatta atataaattt ctattctaat tcaaggtggt
    54301 gaaaaaatgt ttaatgcagg aaatcgaatt ataaatacat ggttgtaccc tattcaagat
    54361 ggctttgtct tgattgatac tggatatgaa aatggtttta aacatttcaa aaaacgaatt
    54421 tctaaattca acataaaaat caaagatatt cgatacatat ttctaactca tgctcatgat
    54481 gaccatgttg gttttctaaa tcagattcta gacgaatctc ctaatacaaa gattgttatg
    54541 catgataaag ctttagaaat tctatataaa ggtcaaaact cttttattgg tggttgtacc
    54601 agccgtactg cctttctctt ttgccaaatt atgaaactat ttggaaaagg tgagcatagt
    54661 ttttctccac ttaaacaaga atttgaaaaa aggtgtattc ttgtgtctga caagaatcgt
    54721 aaagaaattg aaaaagaact aaatggaaaa attatagata caccaggaca tactgctgat
    54781 tcaatttcac tactaattga tgaaggtgtt ttattttgtg gagattctgc aatgaatgga
    54841 tttccaagta ctcacaaaat taccatattt gcagaaagca aactagaatt tattcaatct
    54901 tggaaaacaa tcatcaatac aaaacctaaa atgatttatc ctggacatgg aaaaccattt
    54961 gaatacagta aattagaaca aaatctaatc tatgtaaata aaataaattt atatcctcta
    55021 cataattcaa aagatattca caggtttttg tagaaaatac aaagtaaatt tatttgatta
    55081 attaaaaaat ctaacacttt actacgctac ttattttaat aacttaatct tccactagct
    55141 tttcataaaa ttttgtttta aaattaattt taaagcgcat atgttattta aatacattag
    55201 ataaaattcg tcattaatct acttaaagca tatttaacta acaccactca accagaaaat
    55261 tcagaaaact gcattgacac aggaaaaagt ttattttata ctttttttag gacatattgt
    55321 ggacacgtct taaatcgaca aacagaattt aaattgtaag attaaccaca atacttattt
    55381 tttaattata tttttaaaca ttagggagga tattatgaat gataacgtag ttaagaagaa
    55441 aaactttttt gacaggacat taaacagaat agaaactgtt ggtaataaac taccagaccc
    55501 agttacaata tttttagggt tatgtgtact tttacttata ctatctagtc tagttggttc
    55561 tatgggtata tcagtagttc atcctggtac tggagaaact ataaccgctg taaatttatt
    55621 gactgtagaa cagcttcaaa ttcttttagg aaacatagtc agcaatttcc aagggtttgc
    55681 tcctttgggt ctagttctag taactatgat aggtgctggt gtatgtgaca aaacaggact
    55741 tatgacagca acaatcaaag catcagtaag caagattcct gaaacaagag taactcttgt
    55801 tgtaatgact ataggtatgc ttgccaatat agcttcagat gcaggtacaa tattatttcc
    55861 accattagct gcacttgtat atcttggtgt tggtagacat ccacttatag gtttattttc
    55921 tggatatgca gcagtctgtc taggatttgc cgcaaacatt atgataagtg tcaatgatat
    55981 acttgctgca agttttacag ttccagcagc tcaaatgatt gattctggat ttcaagccaa
    56041 tgcaacaatg aacttatttt ttatgatagc atcaactttt gttctaatac ttttggcaac
    56101 atgggtaaca gaaaaaattg tagctcctag atttggtaaa tatgaaggaa atgcagaact
    56161 agatgttgat ggaagtctta gtgatgtaga aaagaaaggg cttaaaaaag ctggtataag
    56221 tatattaata tatgtggcta ttatagtagc tcttagtgta atcggtaaaa aaccattctt
    56281 agctgaccca gaaacaggag atttactatc aaacaatgct cctcttatga aaggtatggt
    56341 acctataata gcactagcat ttttcatacc tggtgttgta tacggaaaaa ctataggtaa
    56401 aataaagaag gataaggatg tagtctctat aatggctagt gcaatgagtg atatgggtgg
    56461 atatataata ctagcatttg ctgcttcaca atttttgcaa ttattcacaa atagtaattt
    56521 aggtctgata ctagctgtaa agggcggaga atttttaaaa tcagcaggaa taaatggacc
    56581 tttattgttg ataggattta ttatattatc atgttttata aatttattta taggtagtgc
    56641 atctgcaaag tgggctattc ttgcacctat atttgtacca atgtttatga tggttggata
    56701 caatccagca cttactcaga tggcttatcg tataggtgat tgtataacaa atccacttag
    56761 cccattattt ccgtacttcc ctattatact agcattcaca agaaaatacg ataaagatgc
    56821 tggtatgggt actgtaattg ctaatatgat accatactct atatcattct taatagtgtg
    56881 gactatacta ttaatattgt ttatggtatt taatattcca ctaggacctg gaatacttcc
    56941 ttcatatagc atgtaattta tttaaatctt tctaaaagga gaaataattt atgttagata
    57001 aaaatagact tataaataat tttatggata tggttagaat tgatagccca tctaatcaag
    57061 aattagaaat gtctaagtgg ttggtaaact acttaaaaga aagaaatata gacgccatta
    57121 tagatgatgc aggtgaaaaa tatggtggta atacaggtaa tgtcattgcc tatataaaag
    57181 gtgaagaagg aagtagacca ctttgtttat gtgcacacat ggaccaagtt caaccttgtt
    57241 taggtgtaaa accaatacta gatggtaatg tagttagaag tgatggaact actacacttg
    57301 gtgcagatga taaagctgga atagctgcta tacttgaagc tttagaacat gttattacag
    57361 aaaaaatacc acatagagat atttatcttt gttttacaat ctgtgaggaa gccggtatgc
    57421 atggtgtcaa aaactttaat cctgacaact tgccttgtaa agacatggtg attttagatt
    57481 ctggtggagc tattggttcg atagcataca aagctcctgc tcaacaatct ataaaaatct
    57541 cttttcatgg aaagaaagca catgctggta tagaacctga aaaagggtta aatgctatat
    57601 tagtagcctc tcatgcaata agcaacatgc acataggcag aatagattca ttgactactt
    57661 caaatatagg taaaatagaa ggtggtggag ctacaaacat agtaactgat aaggttacat
    57721 tgactgctga aattaggtct catatacctg aaactttaga gtatgagctt aatcatatgg
    57781 aaaaatgttg taaggatgct gcatctaaat ttaatactac ttatactttt gaacatagta
    57841 tgtcttaccc tagttttgaa cttagtagag atagtcatgt tttcaagtta agtgaagaag
    57901 caataagaca agttggtgtt gttccaaatc caatggtaat tggtggtgga agtgacgcaa
    57961 atatattagc taatcttgga tataattgtg ctatattaag tctaggtatg tatgatgtac
    58021 acacagttaa tgaatatgta aatatagacg aattatatga tactgccaaa atagtttatc
    58081 atatgattaa attataaata tcataatata actctttaaa ttataaaaat aaaaacctat
    58141 gtatcttcaa ctttataagt tatatattaa agttgtttta cataggtttt agtattttat
    58201 ataataattt gttttaacat ttttcataat aagcttcaat attttgcata ataatttgtt
    58261 ctagcatttt taataacaag ctttagtatt ttatattaat aatttattct agtattttac
    58321 ataatcattt gttctaattt ttttcataat aagctttaat actttatata gtaatttgtt
    58381 gtagaatttt atacaatata atgatttata cagttttata aaatatctta aaacagtatt
    58441 tcagtaatat tttttggtct tcctccacca atactagtct cttttgcaca tattcgacct
    58501 aaacctgcat ttactatttt atttaatata cgtcttgcac ttctttcact tacatttaga
    58561 tactctgcta actcttttga atcataaatc ttactttttc tattctcatt tatagcaata
    58621 atttttgcaa ctgactcaca actcattcca gtctttttag atatttcgat taccttttca
    58681 tcagatagca tcaaagaata atttaattca ttttcggaag ctaaaggtcc tcttatgttt
    58741 tcatcttcat ctaccaaata tataccaatt tcttttgaat ctatggagtg tcttaatgct
    58801 ttatgtgcat tattttcagc ctgatacgca gttactccag taccaattcc tatactaaga
    58861 gaaaagccca tgtcttttat ctctctcttt agattgaata gcttatcata attatactca
    58921 ttatcagcta cccctttatg aacaaataca acataatcat ttcttccaag taaaaataag
    58981 gaaccttgaa tacttcttac atagtttact acaagcttat ccatatctga tttttttatc
    59041 atgtcagaat aatagttatc tatcttctct ttataatcta ttaaactcaa tatttcaaca
    59101 gcaatttgag aaaatcttgc cttacttaga gcatattcac tctttacctt gtcataactt
    59161 tctttgatta attgtatagt agcttgtaaa cgaaatacag gatagcctct ttcttttaat
    59221 tcattatata ctgcaccaaa accagttaac attatatccg tcttattttc ttcaaataat
    59281 tttatatgcc attctacaag ttcagactct cctacttcca aagaaaatgg attacaaaat
    59341 acactcgttg ctttaatatc aaattcttta agtgcatctt ccacaacata tctatcaact
    59401 acatctatac tgaatttatc taattttata tttgcacttt ttattgccca aaatgccttc
    59461 attatactcg tcccacttct cggtacaaat gaatgtggct tacttatctc atacttagat
    59521 tttataaatt cataaactgc acatcctgta aatataatag catcacattc gtcttcacat
    59581 ttagaaataa cttctattgt atctactact ttttctctta catatatttt agtctttaaa
    59641 tcactgtcta tctgttttaa atcatccttt atcttaaacc cagagtctga aggacctata
    59701 atacccacta tcataaactt cgctcctaat ccataaatat tatacttttt aaaaattata
    59761 tcctcactat tttctacttc tatttaatta ttttgaacta ctccatccta cctacattta
    59821 gaatggaata attagcttat ttttgataaa gtaacttctc aaaatcagaa cttggaatag
    59881 gcttacaata ataataacct tgaattacca cacaatctaa actcactaaa aattcagctt
    59941 gttcttttgt ctctacacct tctgccacta catccatatc taaatctttt gccatggcta
    60001 tagtgtgctt taaaactatt ttttctctgt ctgtgattcc ttcctcatta aagaaaccac
    60061 aatctatctt taatgtatca atattaatat tttttaacat atttaatgaa gaatatgctg
    60121 aaccaaagtc atccatattt aaaacaatac catccattct aaggtcggct attatcttag
    60181 taaataattt tatattttta ataaataaac tttctgtaag ctctaattct aaaaaagatt
    60241 ttggtatact atatttattt attaaactta aaacaatttc tttaaaatgt ggattatgca
    60301 aatgtaatct tgatacattt acagagatag gaactggctc ttcacctaaa tctatccatt
    60361 ttctaatcaa agaacatact tgttcccata catacatatc taatctgata ataaacccat
    60421 tcttctcaaa tagtgaaata aatttaattg gaggtattat acctttttct ggatgaaccc
    60481 atctaaccaa tgcttctgca ccaacaattt tatttgcatt aagattatac ttaggttgta
    60541 aatatacatg gaattgccca ttttcaagtg cgtattccat ttccctttcc atctgttttt
    60601 cttcaagtgc atcatttctt atagtatcat cataaaatat atagttgttg atactttgtt
    60661 tctttacttt tttgtgagca tatcctgcca tttcacacgc atttgtaatt ggaatatgat
    60721 tatccaaaat tctataaacc ccaaaacatg gtactaacat atattcaaat ttttttctat
    60781 ttaagctatt tttaatctta taaattactt tatgaatatc tctatcagag taactctcat
    60841 aaaaaatgca aaatacatct gcatacatac gacaacatat accattagaa ccaatgtttt
    60901 tttgaatcaa ctctgcaaca tatattaaag ctttatctcc tcctctaact ccataaatgt
    60961 cattaattac cttgaactta tctatatcca tcattataat tgcataacgc ttgtcaggat
    61021 atcttttaag cattaaactt atttgttcac aaaaactttc ataattgtat agtcctgtta
    61081 atgtatcttt ttggttttta tgtagttgca taagataatc tatatttttt atagcaacta
    61141 aaatatgtgt ttgtttctca cctaacttat ttttactact aatctttaac atataaatta
    61201 atgcccaata gtacttttta tctattccta aacgtctata ctcaaaattt agttctaaat
    61261 cgtcttgctt gctattatta agactatcaa gagattttag aaggtggtta tcattaaata
    61321 atattatatc atcaggatga attaaatatt tttttatgta tgaaaaagtt ttttcaagat
    61381 tttcctttat aggaaaacta aaaatattgc tctctgattg ataaattgga gtaattaaat
    61441 tcgtatcaat gcaaatagat aaaattatat catatgtatt ataagctaat ttttcataag
    61501 ctttagaata cccttttatc attaaatcat caaaataaac cttatcaact aactctttat
    61561 gtttaaataa aatattattc gtcgaatcag ctaagtcact aattactttc atttcattat
    61621 ttctaagttt gttcttatta taatacctct tcttatcttg gtacattctc tcatcagcaa
    61681 ctttaattag cttatgtata tcaatattat cgtcactcca aatactgccc actgctacac
    61741 tatatatcat ctcatcctta aattcttcac ttaaccaact cactaattct tcaaatagtt
    61801 gttttgatat atcttcacat aatacaacaa actcatctcc tccaatacgg taaacattat
    61861 aagaatgaaa gtattttttt attattacac atgctgacac aatagcagaa tcgccattag
    61921 catgtccaaa gttatcatta atatctttta acccatttat atctacaaat acaactccta
    61981 tggatttaac ttttcctttt tgaaaattat ctatatactt aatatattta tttctattat
    62041 atgcaccagt caagaagtca tagtagctca tataatttaa tttattttct acttttcttt
    62101 ttttcatctc agttaataaa aaataagata gggatgtcaa aagagaggta tctccaacag
    62161 ctttatgtgg attatcaact ccaataaacc ctactacttt atcatcttgt tttagtgaag
    62221 atgtcattaa actttcaatt ttttgaggtt ttaaaatttc atattctatt ggctgttctt
    62281 cttttatatt ttctatatca tcaattatta caaaaccttt ttgttcgaat aataaaaacc
    62341 aattctttaa ttcattaata tcaagatttg ttagtgcctg tttttgttca tcaacacctt
    62401 cattgcacca ttcatatgta ttagttactt ttgttctatc ttctgatact tcaaaaacat
    62461 atgctctatc agctttatga aatttaccaa tattggttaa tacaagattt acagcatcag
    62521 aaaaattaga ttctgttata agatgtttaa tacatccaac taataactcc tttatctcta
    62581 atttttctgc tattgactta cttatatctt ccttttctgt aatatcaaga gctatttcta
    62641 atcgtgcatg tttgccctcc catttaatta acttgtcctt taatataaaa tgtctatttg
    62701 ttcgagtatt cgtattttcc catatgtaat attcatcttc ttttaaaata gagtttgtac
    62761 aaaattcgca gggagaatct ttcccctgta atgctttata acattttaaa tgggatatat
    62821 cattaagtcc cattgccttt ttcccaattt cattaatata taaaagttca tatgtatcta
    62881 aagaagaaac atatacaatt tcatccaact catctattaa atttattaca tccatttata
    62941 tatatctcct tttattcatt ttccagattg aatttttaaa gcttttaaaa ttttgctata
    63001 tatttggcaa tgatattata cttctttatg ttttaaaata gtaccttaat gaggttctat
    63061 tttttagtaa atagaattat tattgtgtca atcgtacaat agagttttgt aatacttaat
    63121 ttaatatatt tataattaac tatcttatta tgtatttaca attaattctc atataaatga
    63181 caaatctcca cctcaattaa gtattccaat catatatgag gataatactt cattcattta
    63241 aaaatataaa actattatat attaaaattt cttcaataat aaattattta gattgttact
    63301 ttgatatatt atataatatc acaaaggctg atataaaaag acaaaaaggg caattttttt
    63361 atatcaaaaa aaatgttaaa ttgatattat ccatatataa attgatatta tccatatagg
    63421 tgctatattt aacaattcta cttacttccc ttacacttat tagcatatag ttattaagag
    63481 tttgttgcaa aacaacactt agcacacttt aaaaagtgtg gtctaataag taatcaacga
    63541 agaagacata ataaagcata aaataggata tacttttcca cgtcatcaaa attgaggatt
    63601 ttattattaa tatatgataa aatatgctta ataaattaaa ttttaatggg agaatagtta
    63661 tgaaaatatt tagtttcttg ttgtttgtag tgggaatatg tttttgtatt gctggattta
    63721 tggggcattc ctcagctttt tctggtgcaa cattgagttt ttttgcaact acaatgatag
    63781 ctgtaagaca agtcaaaact aagaaaaaat gaaataggca aatcctaact ttataagtta
    63841 atattacata agtaattagt ctaaaattag atactttttc tattacaaaa atacatcatc
    63901 cactttgtat tctcttaaaa aaaataaaat agctatgtaa attcaagatt agatagacta
    63961 actctctatc catttcattg taaaatatac atagctattt gtattcgatt taaaatactt
    64021 agattttctt acataacaaa taatttctat ctgattatta ctcatgttca tttattaacc
    64081 actcagcaac taatcattta gtatctattc atccgccata cggtaaccta ccccaacctc
    64141 agtcaaaata tattctggct gagcaggatt cttttcaatt ttccttctta tacttgccat
    64201 aaaaactcta agcgactgat tttcactttc atagtaattt ccccaaactt tatctattat
    64261 aaacttatgg gttaagactc ttcctgaata cttagacatc aactcaataa tcttatattc
    64321 gattggagtt aaatgtattt cttcaccatt aattgacaca atatgatttt cataatctat
    64381 ctttaggttt ttaacttcaa aagactttgg agcatcatta tttatattat cctgttgagc
    64441 tttatttcta agagccacac gtactctagc caaaagctct gttacactaa aaggtttagt
    64501 taaataatcg tctgctcctc catctaaagc ttccacctta tctctctcat gctctctcgc
    64561 tgaaacaaca attattttat tagtctttgc acatgcccta actcgtccta ttacctcaat
    64621 cccatcaata tctggtagtc ctaaatccaa aattatcaaa tctgggtcaa gagaatgtat
    64681 aagtgatata gctgttcctc cattatctgt ctctacacac ctataatttt gagtttcaag
    64741 agatactttt ataaatttac aaattggctt atcatcttct acaattagaa ctaatggctt
    64801 tatttccact tgtctttccc ctcctcatca tacataggta tgctaaatct aaatgtagct
    64861 cctccagaag gattattaaa ggcgacaatt tctccaccat gagcttctac tatagattta
    64921 catatctcca atccaagacc aatacctctt ctttcaagat ttctagactt attcttagta
    64981 taaaacctat taaaaatatt cccgatatct tcatttggta ttccttttcc attatctgca
    65041 acttcaaata gtacttgatt tgactctttt tttacagtta gttctatctt agaattttta
    65101 ggtgtatgcc ttatagcatt atcaattaga tttactaaca cttgttctat taataataca
    65161 tccacatgaa cgattattat ctcatctgga atatttgttt ttatgtctct actattggca
    65221 aactttttga ctcttaatat agattcagct attatttcat caacaacctc tggtcgtttt
    65281 tcaatatcca attttccttc atctattctg gtcatactaa gtatattctc aacagaatga
    65341 gttagccaac tcgtatcttc atatatattt ttcaataatt ctactctagt ttctttatct
    65401 atcacatcat cattttcaag tattgttgaa gatgaaccca atatacttgt aagtggagtt
    65461 cttaaatcat gagaaattga cctaagcaag tttcctctta acctctctct ctctgcctca
    65521 aggtttgctt ttttattttt ctcaaataaa ttttctctat caattgccaa cgcaacctgt
    65581 gttgaaactg cttctaatag tatcttttca ttttctgtaa taatatctat cttaaaacac
    65641 gcaacaccta taacaccaag aacatttgat tcttgacctt ttatagggaa ataatatgca
    65701 ctgctgtttt tacaatattt tgtcccaatt ccaactgggt tacctgtcct aaaagcttct
    65761 tttatagctt ccttttctaa tactgaatgg aatatattct cacttccatc attgttacaa
    65821 atataaatac ttggcttacc tagattatta ttctcatctg caatagtcac tattacagtt
    65881 ctatttaata tatttactaa attagaccca caaaattcaa taatttgatt tttatttttt
    65941 gctttaagca acgttttgtt attctcatag agcaatctta tcattttttc tctcttatga
    66001 gaaagtctca cttctctttt tatcctagaa gttaaagtac ttgttataat tgctgccatt
    66061 agcataatac aaaaggtcat aggataatct tttctataag ctaaaaaagt atataatgga
    66121 tgcgtaaaga aaaaattaaa tgatagcact cctattactg aagaaagtat tccaaaaaaa
    66181 tatccatagg ttatacttgt agcaaatagt acacctaata tgtatactag tataatatta
    66241 gattcattaa aacctacctt ttcaaaaact actgatattc cagtagcaat tgtcataacc
    66301 aatatagttt ttatgaagtc cttaataatt atctttttac tgagatagcc atcttcatca
    66361 taatcatact cttttaagtc ttcatgttgt agtcgttcct ttttcattta ctacaattcc
    66421 tccttattgt tactgtttaa attggctcta ttttatataa tacaatttta tcataataaa
    66481 ttcaatcaat acatttaatt aatgtactta aattactaaa aggtgctgtc ttaaaatgaa
    66541 aataaatctc tatttcaaaa cagcacctat atatttaaat tactaattta gtttttacat
    66601 acttaaatca atagttttat tcaatttcat aaattataat acttcaatta taaaacattt
    66661 ctatccaaca agcataaata taaagtgggc acatatacct gcacataaac cacctatagt
    66721 atgcgaaagt atcgctttac cagccaatgg tcttgcatct aaagcatcca tcatacctat
    66781 gtgtgtactt aaatatccac tccaacacat acccattgct gtgaatactg ctatatcatt
    66841 aggagttata gcgcctgatt ttataaactc tggtactaaa gatattgctg ctccaacagc
    66901 tcctaatgca gttacaggga atgctattgc ctctggtgat gtgaatccaa ataatggttc
    66961 tattatgaag ctaatcttat caccaatagc aggtaataat tttatacctt catatgcagc
    67021 tcctgtgtaa acagcttgac ctgtagcagg gtctgtagat ggtccaaaag ttaataacat
    67081 aactaatgta caaactacta aaactcctgg tattatagcc atacccattt caacacctaa
    67141 cttaccacct tcaagtatag catccaatgt tctttggaat acattaccat cccttatttc
    67201 tctaaactct tcaagttttg cacctttatc atttatttgc ttttcagtat catttttagg
    67261 gtcataatta taatactttt tagtaaaagt caacataatt ctaacactaa taatactacc
    67321 tattattgcc ccaacattac ctattatagc tggtagtaca tattctttac cttgagctat
    67381 cataaaagtt gttacaataa gtcccatacc aaaggctgtt cctaaattac ataaagcagg
    67441 tacttgatac ttcttaaaat attgtgtaaa tgttttgtct ttagcaaatg gtataatagc
    67501 tggattatca gataaatatg ttgcaactac tcctgctata ctagcaccag gtaagcccca
    67561 tataggtctc ataagaccct taaatatctt attaactaaa gatattactc caaactctga
    67621 aagcaatgca ctaagtgcac ctgcaagaac tgccatagcc attattaaaa atactgtgtc
    67681 taataaaagc gcatgtgctg tactcattat tactttaaac atcattcctg cacccatgat
    67741 gcttcctaca tatccaaatc ctaccgccaa tagtacaata aatacgaagg tttccatact
    67801 tactgccttg actcttctct tatccgacag cttttccatc ttgaaatctt ccccctttta
    67861 attttaaatt aaggttccta acattggtac aaattttttg gtacaaactg agttctaaaa
    67921 cttacactcg taatgcaagt tgtcagtttt ttgaaataaa aaaaaattac gtttatagaa
    67981 taagaatatc ctctttaatt tggatactct tattctattt tatgttatta tattatcatc
    68041 cttttgttta aaagtcaatt ttttctattt ttgttgttta attttattta tactcttttt
    68101 atatttttca ttttctttta tctttgtaag tactccatat aagttgactt ttctaaatac
    68161 agtagttata aataccaatc ctaatgcaat tgaacttgca cacgataatg tactcacccc
    68221 atattctaca gcttttatat aattattggt caaaacagaa tacatagtat tatatattcc
    68281 ataacctggc actaatatta ttaaacagca aacacttaat gtagttgctg gagtcatata
    68341 aattcttgca cataactcac aatatatcgc aaaacaaact gtagctataa aaaaacataa
    68401 gttttctgtt actcccatat ttaaaagaaa tttatacgaa aaccaagcta tacttccacc
    68461 gattcctgct agtattaagt tttttccttt catattaaat agcactccaa agcttaaggc
    68521 agtaaaaaaa gctgctatta cttctataaa caaatgcact tatatccccc ctaacttgaa
    68581 gtacaatcca agtaccaaga acattcctac tgctatagat acacctacaa aaaatacttc
    68641 tgctaatttt gcaagaccag aaatcaactg tccatctaac aaatctctta atgcattagt
    68701 caaagcaagc ccgggaacta agagcattat tgctcctgct attaaatggt ctaacgtctt
    68761 tatgaatccg agctttaaaa ttaaaattga acaagaagct ataataactg ctccaattgc
    68821 atttacaaaa aagtcattaa gggaagattt acttaaatac ataataacaa acttagtcag
    68881 aatcccaaca gtaaatgcag ctataaattc ttccacattt cctccaaata atatcgaaaa
    68941 agttgctgct gcaatacctg caaaaaatat tgttattaaa tccgagtaat agttatcttc
    69001 acttatttca tctaaaattt tctcacataa ttcaatatct aaattattta tacttattgc
    69061 tcttgataat gagttaactt catgaaccaa gtttaggtct actcttcttg agcttattct
    69121 tttaattgct gaatgtaatt tcccatctac aaatacagat gccattacag ctgttggagt
    69181 tgcaaataca tctacgtggt ctattccaaa agattgacat attctagcta tcgtttcttc
    69241 aactctatag gtttctcctc cactttgcaa catagcttta cctgcatttg aggaaaagtt
    69301 taaaattcta tctatatcca caaaacatat ctcccattct tttatagtat tattcatatt
    69361 ttaatacaag atattattta tttaaactat tttaaataat tcatatccaa catttacatt
    69421 ttatgaaaaa acttgttttt tatgcttgtc aaaatcaaat tttaagcttg tttacaccat
    69481 aaaatggctg aattaatatt tgacaaacac tttcaaccat ttatataacc ttctaaattg
    69541 tataactttt tactacaaat aaaattatat ctcttttaat tctttctctt gagtatttag
    69601 cttatagtaa cttcatattt atatatgtac aatataaaac attattttta tgatacaaaa
    69661 tataatttgt aaatgtatat atgtattaac tgtgtatata taaattattc ttaaccttat
    69721 cagttttttc atatatcttc atctataccg accatatatt aattacattg accatatatt
    69781 aataaatgat attacataga cttaagtata ttaaaaaact taaatttagt tatttaacaa
    69841 cataatactc taatttaatc tataaaaatc catacctaat ataatgcaac tcttatttta
    69901 acaccatcta ttacacaaaa caacatatta aaaagtaaaa tacaaaatat ctactataaa
    69961 ccttatttta atactgaata tatattataa tatatttaat gtagcttaaa tatagtttaa
    70021 acataaagaa aggaaacggt atatgctaag aaaagataaa gttctattat ctctacataa
    70081 attatgtgaa aatatgactt taaaagacct tcaatcagat aaaacaggat tcactacaat
    70141 agaaattgct aaccattcat ctcttgatag aagtaatacc agtaaagaat taaataacct
    70201 atacaatgaa aaaaaagttc tgaaaatatc tggtaagcca attttatttc tacatgctag
    70261 tattatagaa aatttaattg gccgtacttt gaacagtgat gaattttcta taaataattg
    70321 taatgagcta cttaaatcaa gtaaaaatga ctcagaagat attttttcaa cattacttgg
    70381 acatgattct agtcttaaac tacctataga aaaagctaaa tctgctatac tctatcctcc
    70441 aaaaggtctt aatacattac taataggacc tactggtgtt ggaaaaagta catttgctga
    70501 aacaatgtac aaatatgctg tagaaagtaa aatcttttct tctgaaagca aattcgtagt
    70561 atttaactgt gctgaatatg cagaaaatgc taacttatta ttaagtaatt tatttggtta
    70621 tgtcaaaggt tcttttactg gtgctaataa ggataaattc ggcatagttg cacaggctga
    70681 tggaggcata ttattcttag atgaaataca cagattacca ccagaaggtc aagagatgct
    70741 ttttcttttg atggacaaag gcatatacag acgattagga gaatctgaca ttgtgcataa
    70801 agctaatgtc tttattgtgt gtgccacaac agaagatata cattcttctc tgcttggaac
    70861 ttttttaaga agaatccctg ttacaatcaa cctacctgct ttacaggata ggtctttaaa
    70921 agaaagatta tctcttatta aatacttctt tattatagaa tcaaaataca ccaatgcaac
    70981 tataaaagtt cacaaagatg taattaaatc attactcctt tatgattgtt ttggtaatat
    71041 aggtcagctt aaatctgaca tacaacttat gagtgcaaga gccttcttaa attacaaaac
    71101 tggacttaag gataatatag aaatagattt atcccttgtt cctgattaca tctatattgg
    71161 tcttttaaaa ttgaatgaaa atcgtagtaa tctaaataaa ttatcagaac ttgattatat
    71221 gcttttttat gaatttaatg gtaataactt agaagttgaa tatacaaaag aactatctaa
    71281 atacaatata gatacatcaa acaatggatt taaatactct acagagattc cttatctgga
    71341 aaatgatata aggagtatgt ttataaatta catggaaaag tactctacaa aattactttc
    71401 gatatcttca gtaactcatt ctgattatac aagtaatgag atttttaaag taatcaatcc
    71461 aaagatttac tatgctgttg aacattcttt aaaagaggct gaaaaaatat cgagaaacaa
    71521 atacacaaaa caaacttata ttgctctttc aatgcatata agtgcactta tagaaaatat
    71581 aaatcaagac acatataatc ctaagtacaa tttatataat gataaaattt tcttagataa
    71641 agatttaaat atagctaaaa tagttttaag tataattgaa aatgacttac aaacatcttt
    71701 acctaaagat gaagtaaaat ttatatccat gtttctaaat agcatgtatc ttgaaccaaa
    71761 caatcaatct gaaagtatag gagtcataat acttgctcat ggaaattcaa cagcaagcag
    71821 tatgtgtgat gtagcaaatt cattgcttgg tacaaaccat tgtaatgcaa ttgacatgcc
    71881 tcttgatgta aaagtaagta ccatacttga taaaactata gagttggtaa aagaatgtga
    71941 cgaaggtaag ggtgtacttc ttttaacaga tatgggctct cttatagctt ttggagaact
    72001 tatttcagaa aaaacaaaaa tcaaaactcg ctcaattgaa atggtatcta ctccaatagt
    72061 tttagaagca gtaagaaaaa gtacactacc agaaatgact ttggatgaat tagctaattc
    72121 cttaagctct ttaaatccat atattggacg agcagcaatc gattcaacag aaataaacta
    72181 tcctgaaaag tcaagagagt atgtaataat aactacttgt ataacaggat atggttcagc
    72241 tatgaaagta gcagacttta taaattcttc acttaaaaat attagtaaat acaatattaa
    72301 tttagttcct cataatatag aaagttttaa aatgtataag aataaattta gtaatactaa
    72361 aattctggca gttgttggaa gtgtagattt taatgtagct aacacccctt ttatacacat
    72421 agaggaacta ctaaatggat atggcctaga tatgctaaac aaaataatag aaggtacatt
    72481 caatgccaat agtattacaa atataaaaga aacaaatcta tcatacaaca gtttaataat
    72541 aaactttatg acccaaaact tagagctttt ggactctgtt aaattattca actatgtcaa
    72601 ttcttcctta tttacaataa tagaattaat agatgaaaac ttaaagagca aatttaagct
    72661 aggatatata ctacattgct cttttatgat agaaagatgt tttaaaaata caacttttcc
    72721 atataataac attactgaat taattagtaa aaatcatgaa ctatatagtt taatacgtga
    72781 agcctttaag ccaacagaag cttattttaa tattttgata ccagacgaag aaattgctta
    72841 tataatagac atgattaatg agtatctaaa taaataaaat ttatagcact tattttgtgc
    72901 atattaatta atatatgaaa tggaggacga gattttgaaa ggaaaaataa aacagttaac
    72961 aatacttgca ttaattttta tatttataac tcctgtattt gcatttgcag atactccacc
    73021 agtaccaaat tcttcaagag cagcactact tatagaccag gaaactaaaa gaatattatt
    73081 tgaaaaaaac attgatgaaa aaatgccatt agcgagttta agtaaaatga tgaccttttt
    73141 attggcaata gaagcagttg ataaaaatca agttaaagag actgatatgg tgaaaataga
    73201 caagtctaca gcttcagtag gaggttctac ttgtaaactt aaagatggtg atgaaatatc
    73261 tctaggtgag cttatgcagg gtctaatgct agtatctgga aatgatgctg ctatagccat
    73321 agctaaacat attggtaaaa ctgaaaagaa ttttgtaaat atgatgaaca agaaagcaga
    73381 agaaatagga atgattgata cgtattattt taatccaaat gggcttccta tatatactga
    73441 cccagaacat aaagaacctc ctattgaaaa tatgtcaact gctcacgata tagttacact
    73501 tggaaagtat atgtacgacc attatgaaaa tcaagttaca agaataacca ctatgcaagt
    73561 atataatgat actaaaaagg attttacaca ttataacaca aatcctctgc ttgtttcagt
    73621 acctggtgtt gatggaataa agacaggata tacagataat gctggatatt gccttgcatt
    73681 ttctatgatg gtacctaaag atgctaaaaa cgaaagaaat catagattga taggtgttgt
    73741 acttggtgat ggtaacaaga aaaatagaat ttcttcttcc gctactttat tgaaatatgg
    73801 taaagataat ttccattcta aaaagatagc acataagggt gatattatag agactccttg
    73861 tgttgatggt attgatgatt ttaagataac agttaaggtt gataaagatt tgtatggtgt
    73921 tgtttcagat aacgaaaata tcaatcctaa ggtagtgttt aaaaatatga attatcctat
    73981 ccataaggga gatattgttg gtgttgtaaa gtattataat gactctggta aatttgttgg
    74041 aagtgttgat gtaaaaagtg aaagtaatat aggatgtatt cctttgaagg ataagattaa
    74101 gattaaggtt gctaagataa ataaaaaact tgagattaaa aattctgttt gttttaaagc
    74161 atagtaaagc atattattaa aagggtatgt taaatttata aagactccac tttgtggagt
    74221 ctttttgttt tttacaaaaa attaaaatag tggcaacaat tgaggatgtg agggagagtt
    74281 gccactattt tgtatagggt attatattat gtttttaagc tagttttact atcttctatg
    74341 tttatataat aactcttgtg tgtgaattta attgataatt aatatgaaaa ttatgtgaag
    74401 ttttaagtta gttgacttag actattgtaa attttttcag aaaaattctg ttcataagtc
    74461 tattagacca ccgaattatt tacctataat attccgatca aaaaatctat tcttttttaa
    74521 aagtaaggtc atgattattg tacatatata aaaattccga aaattaatct acacactagt
    74581 aacattaagt ataataaatt tattttagta aaactattaa aataacctca taagaaacta
    74641 tagattaaat caatcaatct aatctacagt ttcttgatta ttccttaata tttataattt
    74701 acattatttg tttattttaa aactatctgt tacaaatcta gtcaatgttg aaaataaatt
    74761 cgctctgaat atagtagatg atg
//
LOCUS       DAEPID010000011        69619 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.011, whole genome shotgun sequence.
ACCESSION   DAEPID010000011 DAEPID010000000
VERSION     DAEPID010000011.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 69619)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 69619)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..69619
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.011"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            complement(121..894)
                     /locus_tag="KR257_000818"
     CDS             complement(121..894)
                     /locus_tag="KR257_000818"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420464.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SigB/SigF/SigG family RNA polymerase sigma
                     factor"
                     /protein_id="HBH0029545.1"
                     /translation="MKNVANATHYLNMDTKELFNLYNKNKNVDIRNILIERHLYLARL
                     LAKKYINKGVDFEDIYQVASLALIYAIDRYDVEKGFEFSSFATPTIVGEIKKYFRDKV
                     WTLRVPRRIQELSKKISDAKIKLEQENKKHPKVKDIADYIGVSEEDVLEAMEASYGYQ
                     PMSLDSSSNDDSEDKDITLIDKIGKEEGNFGSIEYEDFINKFIETLNELEVKIFKDRF
                     FFDKTQSSIAKELGISQMTVSRLEKKVVEKLKKEYEKNL"
     gene            complement(894..1280)
                     /locus_tag="KR257_000819"
     CDS             complement(894..1280)
                     /locus_tag="KR257_000819"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429308.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding protein"
                     /protein_id="HBH0029546.1"
                     /translation="MEITTNPDYVSIIRLTASGIANKMGFPIDDIEDIKVAVSEACTN
                     AIKHSKDDVFNIVFNILDNAINIEIQDNGKGYDVSSISTPDLENPKESGLGLFIIKTL
                     MDDVDIESEHNQGTKIKMTKYLGVDI"
     gene            complement(1305..1622)
                     /locus_tag="KR257_000820"
     CDS             complement(1305..1622)
                     /locus_tag="KR257_000820"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009894128.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="STAS domain-containing protein"
                     /protein_id="HBH0029547.1"
                     /translation="MSMNIDSNLDSQNKFWNVCLDGELDVSTADKLKEHLHALIEKNM
                     LDVKINLKDLDYIDSTGLGAMIGVLKKLKINEKEIYIVNPKSNVRKIFTITGLDKIFK
                     VEG"
     gene            complement(1634..1894)
                     /locus_tag="KR257_000821"
     CDS             complement(1634..1894)
                     /locus_tag="KR257_000821"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420469.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF948 domain-containing protein"
                     /protein_id="HBH0029548.1"
                     /translation="MNAWGWQIGAVLVGSSALIVAIYLAKTLNSINKVVEKAYKIVDY
                     NERHIQDIVENASSISKGIDDIVYVINKILSIGNIFKIIKRK"
     gene            complement(1894..2190)
                     /locus_tag="KR257_000822"
     CDS             complement(1894..2190)
                     /locus_tag="KR257_000822"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420471.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YtxH domain-containing protein"
                     /protein_id="HBH0029549.1"
                     /translation="MCNKRSCKKGGFLLLGAILGFIFGMFFAPKKGSELRKETKEKFN
                     DVKENPKEVLHETFNDVKERIINLVDDDNNEEDIKISEEDIVISKSFDDEGDVN"
     gene            complement(2259..4685)
                     /gene="gyrA"
                     /locus_tag="KR257_000823"
     CDS             complement(2259..4685)
                     /gene="gyrA"
                     /locus_tag="KR257_000823"
                     /EC_number="5.6.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422332.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA gyrase subunit A"
                     /protein_id="HBH0029550.1"
                     /translation="MEENNKILPIEIAEEMKKSYIDYSMSVIAGRALPDVRDGLKPVH
                     RRILYSMSELNLTPDKPYRKSARIVGDVLGKYHPHGDTAVYYAMVRMAQDFSTRALLV
                     DGHGNFGSVDGDSPAAMRYTEAKMSKLSLELLRDIEKETVDFKPNFDESLKEPSVLPA
                     RYPNLLVNGSNGIAVGMATSIPPHNLAEVIDATVYLIDNPECSVDDLIKFVQGPDFPT
                     AAIIMGKESIAEAYRTGRGKVKVRSRAFIEELPKGKQQIIVTEIPYQVNKAKLVERIA
                     ELVKEKRIEGISDLRDESNRNGMRIVIELKRDANANIVLNNLYKHSQMEDTFSIIMLA
                     LVDGQPRVLNLKQILYHYIKHQEDVVTRRTKFELNKAEARAHILEGLKIALDNIDAVI
                     SLIRASKTGQEAKLGLIEKFKLTEIQAQAILDMRLQRLTGLERDKIEAEYEDLIKKIN
                     RLKEILADERLLLNVIKDEITIIKENYSDERRTEIRHAEGEIDMRDLISDEEIAITLT
                     HFGYIKRLPSDTYKSQKRGGRGISALTTREEDFVRHLVTTTTHSRLLFFTNKGRVFKL
                     NAYEIPEGKRQAKGTAIVNLLQLSADEKIATLIPIDGNDENEYLLLATKKGIVKKTKR
                     EEFKNINKSGLIAIGLRDDDELIGVELTDGKQEVLLVTKEGMSIRFDENDIRYMGRTA
                     MGVKGITLSKEDFVVSMNLCSKGTDVLVVSKNGFGKRTNIEEYRSQIRAGKGIKTYNI
                     SEKTGTIVGADMVNEDDEIMIINSDGVLIRIRVNEISLFGRVTSGVKLMKTNDEVNVV
                     SIAKINIEEE"
     gene            complement(4705..6606)
                     /gene="gyrB"
                     /locus_tag="KR257_000824"
     CDS             complement(4705..6606)
                     /gene="gyrB"
                     /locus_tag="KR257_000824"
                     /EC_number="5.6.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003226808.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA topoisomerase (ATP-hydrolyzing) subunit B"
                     /protein_id="HBH0029551.1"
                     /translation="MKQEYGASQIQVLEGLEAVRKRPGMYIGSTSPRGLHHLVYEVVD
                     NSIDEALQGYCSDIYVSINEDGSVLVKDNGRGIPVEIHPKTGKSTLETVLTNLHAGGK
                     FGGGGYKVSGGLHGVGVSVVNALSKWMVAEVYLNGKRYKQTYEKGLPTSKLEVVGESQ
                     DKGTMIQFMPDETIFDEIEFKYETLEYRLRELSFLNKGIKIVFEDKREGQEKRKEFHY
                     TGGLVEYIKYLNKSRTGIHDDIVYIDKKVDDCFVELAMQYTDGYTENIYSFANNINTH
                     EGGSHLSGFKAALTKTVNDYAKRNKFLKENDVNLLGEDIREGLTAVVSVKLPEPQFEG
                     QTKTKLGNSFMRGIVDSVTVDELGSFLEENPSTARIIVDKALRAQRAREAAKKARELT
                     RRKSVLESTSLPGKLADCAEKDPSKSEIFLVEGDSAGGSAKQGRDRNSQAILPLRGKI
                     LNVEKSRLDRILSSDEIKNMITAYGCGIGEDFDIDKARYHKIIIMTDADVDGAHIRTL
                     LLTFFFRYMRPLIDEGYVYAAQPPLYKVTKQKKEHYVYSDKELNILLDEIGRNGVELQ
                     RYKGLGEMNAEQLWETTMNPETRTLLQVTVEDAAIADEVFSMLMGDKVAPRKEFIEEN
                     ARFVRNLDI"
     gene            complement(6607..7722)
                     /gene="recF"
                     /locus_tag="KR257_000825"
     CDS             complement(6607..7722)
                     /gene="recF"
                     /locus_tag="KR257_000825"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420477.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA replication/repair protein RecF"
                     /protein_id="HBH0029552.1"
                     /translation="MKLKSLQLVNFRNYKKLHLEFNGKVNLLVGKNGQGKTNIVESIY
                     MLSFGKSFRTNKDKEMVRFNSENLYIGGSFSKYNKYSLIELIIGKDKKGIRINKVPLQ
                     KIQELLGNLNVVIFSPEDLRLVKEGPKERRAFIDKEISQIIPKYYKYLTNYNKTLSQR
                     SRVLKNIHVDEALLDVYDDTLAKYGSYIYILRRDFIKKIANISENMHMNLTNGVERLS
                     IRYKNQINITDEDTIDTVYNKFLAKLSSNRPNDIESKTTRYGIHKDDLNIFINDLDAR
                     LFGSQGQQRTASISLKLSEIELIKNEVEEYPVLILDDVFSELDEARQKLLVNNLSNVQ
                     MFITSAEVSHKKIFDEKNVTIFNIENGDVISIENGGN"
     gene            complement(7739..7945)
                     /gene="yaaA"
                     /locus_tag="KR257_000826"
     CDS             complement(7739..7945)
                     /gene="yaaA"
                     /locus_tag="KR257_000826"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420479.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="S4 domain-containing protein YaaA"
                     /protein_id="HBH0029553.1"
                     /translation="MTEITIESEYIKLDQFLKLAEIASTGGHAKFLIQEGLVTVNDEI
                     ELRRGKKIKSGDIVEIEGTKIKVL"
     gene            complement(8082..9188)
                     /locus_tag="KR257_000827"
     CDS             complement(8082..9188)
                     /locus_tag="KR257_000827"
                     /EC_number="2.7.7.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420481.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA polymerase III subunit beta"
                     /protein_id="HBH0029554.1"
                     /translation="MKIICNQKILANRIGIAQKAINGKTTIELLKGILISTEEGQLKL
                     TGYDAEIGIETYVQAEIIEKGDVVVDARLFGDIIRKLPDSFVEIETDSENNIYINCVN
                     SRFKIKGYAAKEFPKLPELNEEDLYSIPQEILKNMIKQTVFAISQDQTKPVLMGELLE
                     IVDRNLNLVAIDGYRLAVKSCSVDSLTENIKVIIPGKTLIDVNSLLSGEDNVKVGFNE
                     KNAIFIINDTKIITRLLEGDFIDYKKLLPREHNSRVKLNTKELLNSIERASLLSQSEK
                     NNLIKLSIRDKVMAITSNTEKGNVYEEVEIDLDGDYLDIAFNSRYFIEGLKNIDNEEI
                     FIEFTTNVNPCIIKPTDDVNYIYLLLPVRISSNI"
     gene            complement(9430..10752)
                     /gene="dnaA"
                     /locus_tag="KR257_000828"
     CDS             complement(9430..10752)
                     /gene="dnaA"
                     /locus_tag="KR257_000828"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000428021.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="chromosomal replication initiator protein DnaA"
                     /protein_id="HBH0029555.1"
                     /translation="MMDIVSLWDKTLQLIKGDLTSVSFNTFFKNIVPLKIHLNDLILL
                     APSDFNKDILENRYLHLIEDAISQLSLKKYNIKFVLSEKEVADLNSDSTDLNYRVLYP
                     NLNPKYTFDTFVIGNSNRFAHAACVAVAESPAKAYNPLFLYGGVGLGKTHLMHAIGHH
                     IVSQKKDSKVVYVSSEKFTNELINSIKDDKNEEFRNKYRNVDVLLIDDIQFIAGKERT
                     QEEFFHTFNTLHEANKQIIISSDRPPKDIPTLEDRLRSRFEMGLITDIQAPDFETRIA
                     ILRKKAQLERIDVPNEVMSYIAKNIKSNIRELEGALTRVVAYSSLSNRVISFDLATEA
                     LKDIITTSKNEEINVLRIKEKVSSVFNLKMEDFNSKKRTRSIAYPRQIAMYLTRELTD
                     LSLPKIGEEFGGRDHTTVIHAHDKVSKDIEESEEIKTKIDKIISDLKG"
     gene            11408..11545
                     /gene="rpmH"
                     /locus_tag="KR257_000829"
     CDS             11408..11545
                     /gene="rpmH"
                     /locus_tag="KR257_000829"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420485.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L34"
                     /protein_id="HBH0029556.1"
                     /translation="MSKRTYQPKKRQRSKEHGFRKRMKTSNGRNVLKRRRAKGRNRLT
                     H"
     gene            11623..11967
                     /gene="rnpA"
                     /locus_tag="KR257_000830"
     CDS             11623..11967
                     /gene="rnpA"
                     /locus_tag="KR257_000830"
                     /EC_number="3.1.26.5"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420486.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribonuclease P protein component"
                     /protein_id="HBH0029557.1"
                     /translation="MDFNRTKGLKKDSDFRKVYKHGKSFANKYLVIYILKNKSDYSRV
                     GISVSKKVGKAITRNRVRRLIKEAYRLNIDEKIKPGYDIVFIARVSSKDATFKDIDKS
                     IKNLVKRTDISI"
     gene            11999..12250
                     /gene="yidD"
                     /locus_tag="KR257_000831"
     CDS             11999..12250
                     /gene="yidD"
                     /locus_tag="KR257_000831"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892330.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="membrane protein insertion efficiency factor
                     YidD"
                     /protein_id="HBH0029558.1"
                     /translation="MNKIIYILKEISKHLSNLCIYLVRFYQKYISPLKGPTCRFYPTC
                     SQYSIEAFKKYGFVKGMYLTIRRLLKCHPFHPGGYDPLK"
     gene            12282..12989
                     /locus_tag="KR257_000832"
     CDS             12282..12989
                     /locus_tag="KR257_000832"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429300.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="membrane protein insertase YidC"
                     /protein_id="HBH0029559.1"
                     /translation="MNIIGNFLGLILKVIFEFVNHYGISIILFTILVKIILLPLTIKQ
                     TKSTKAMQDIQPRIKEIQEKYKNKPEKQNEEIVKLYGEAKINPLSGCLPLLIQFPILI
                     GLFSVLREPVAHGVFANKAAFLAADNGFLWIKSLTSPDYVLAVFSGASAYVMQKVMTP
                     KDQLQGSMKVMTYVMAGMSFYWGFIFPAGLTLYWTVSNLFSIAQYYLIMNPLKAKLAA
                     NSKEEKVNEKKPKINKK"
     gene            12958..13587
                     /locus_tag="KR257_000833"
     CDS             12958..13587
                     /locus_tag="KR257_000833"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434235.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="protein jag"
                     /protein_id="HBH0029560.1"
                     /translation="MRKSLKLIKSKSKEEAISKAIAELNLKAEDIEVEILENPSKGFL
                     GFIGAKDGTYEIFVIEREVDVAKNFIEVMLKNANVDAKVNVSQKDNLIMVDIEGKEAA
                     SLIGRRGETLDSIQFLTGLALNKINKDSHTRVLVDIENYRSKREESLIRYANKVAREV
                     AKTRKTKKLDYMNPYERRIIHSALQNDKYVITYSEGTDPYRRLVIECKR"
     gene            13699..15078
                     /gene="mnmE"
                     /locus_tag="KR257_000834"
     CDS             13699..15078
                     /gene="mnmE"
                     /locus_tag="KR257_000834"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898860.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA uridine-5-carboxymethylaminomethyl(34)
                     synthesis GTPase MnmE"
                     /protein_id="HBH0029561.1"
                     /translation="MFIDDTIAAIATAPGEGGIGILRISGEKALKVAEEIFKSMSGKS
                     IEEYNKRTLIYGNIVDNENVIDEVLLAYMKGPNSYTGEDVIEINCHGGFISVKKILEL
                     ILSKDVRLAEAGEFTKRAFLNGRIDLSQAEAVIDVIKAKTDIAHEVAQNQLEGSLSKK
                     IRELRDKVTEILAHVEVAIDYPEEDIEHITYQTLKEKTDELKKDIKKLYDTAESGKIL
                     REGLKTVIVGKPNVGKSSLLNSILGENRAIVTDIPGTTRDVIEEFVNIKGIPLKIVDT
                     AGIRDTDDIVEKIGVEKSKESFTSADLIVMVLDASRKLSEEDIEILEKLKDKQTIVLL
                     NKNDLKQEIEEEKILKYVENNSIIKISALQQEGIEELQDKIESMVYKGSIKNNSSLVV
                     TNSRHKDALSKAYKSATDALIALEQSMPFDFVEVDLKNIWDYLGYINGDTVTEDLLDN
                     IFHNFCIGK"
     gene            15176..17068
                     /gene="mnmG"
                     /locus_tag="KR257_000835"
     CDS             15176..17068
                     /gene="mnmG"
                     /locus_tag="KR257_000835"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012065747.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA uridine-5-carboxymethylaminomethyl(34)
                     synthesis enzyme MnmG"
                     /protein_id="HBH0029562.1"
                     /translation="MKFEAGKYDVIVVGAGHAGCEAALATARMGYKTLIITMSLDSIA
                     LMPCNPSIGGTGKGQLVKEIDALGGQMGLNIDKTYIQSRMLNTAKGPAVHSLRAQADK
                     FKYHEEMKKTLEDEPNLDIAMDEVVEILHEGNVVIGVGTKLGCSFKSKAVILATGVYL
                     NSKIYMGEVAFYEGPNALGYAKYLTDSLVELGLRMRRFKTGTPARVHRDSIDFSVMSL
                     QEGDEKVTPFSFMNENIEKKQEPCYLTRTTEETQKVILDNLKRSAMYSGVIESTGPRY
                     CPSIEDKVVRFSDKTSHQLFIEPEGLNTKEMYIQGISTSLPFEVQLDMYKTIKGLENC
                     KIMRPAYAIEYDCVDPTQLKISLEIKGVENLFSAGQFNGTSGYEEAAAQGLMAGINAV
                     RKIEGKEPFVLDRSEAYIGVLLDDLVTKGTNEPYRMMTSRAEYRLYLRQDNADMRLTQ
                     KGYDIGLVKKDRYERFLNKKAAVEKEFERLKNERVTPKEVNSLLEEKGATPIKVGISL
                     YEFLKRPEVTYELLEELGKGAGEDVSREVKEQCVIITKYEGYIEKQLKQIDQFKKLEN
                     KKLDEKINYSSIEGLRLEARQKLDDIKPISIGQASRISGVSPADISVLLIYLEQIRRT
                     RGGKGE"
     gene            17061..17780
                     /gene="rsmG"
                     /locus_tag="KR257_000836"
     CDS             17061..17780
                     /gene="rsmG"
                     /locus_tag="KR257_000836"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729282.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="16S rRNA (guanine(527)-N(7))-methyltransferase
                     RsmG"
                     /protein_id="HBH0029563.1"
                     /translation="MNNIELLKNGIEGFNIDTNDSMLEKFKIYREILVEWNKKMNLTG
                     IEDEKEVYIKHFLDSISAVKNGYIKNGMSIIDVGTGAGFPGIPLKICLDSLELTLLDS
                     LNKRINFLEEVSRVLELDNITFIHGRAEDFGKNEDYREKYDVATARAVAGLPILMEFC
                     VPFVKVGGYFICLKGPNANLELEESQKAIDVLGLEYIEKIDVELPEVDLNHNILVFKK
                     VMETPVKYPRKAGKPAKNPIK"
     gene            17943..18728
                     /gene="noc"
                     /locus_tag="KR257_000837"
     CDS             17943..18728
                     /gene="noc"
                     /locus_tag="KR257_000837"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429292.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nucleoid occlusion protein"
                     /protein_id="HBH0029564.1"
                     /translation="MEDKRVMEIPIEDVVPNPYQPRKIFSQVSLEELSNSIKVYGIIQ
                     PITVRAKDGKYELIAGERRLRAAKLAELKTIPAIINNMNDESSAVLALLENLQREDLN
                     FIEEAIGYENLIKEHAFTQQQLAEKLGKNQSTVANKLRILKLPNDIKMKLIENNLTER
                     HARAFLKLPSEDLMQSVLDKVIKNELTVKKTEKLIQDVLEETKVQEEPDKKQNIKGAM
                     SIRIYINTIKQAFDAISNTGIDAKYNEIDKGDYMEVVVKIPKK"
     gene            18863..19636
                     /locus_tag="KR257_000838"
     CDS             18863..19636
                     /locus_tag="KR257_000838"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420496.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ParA family protein"
                     /protein_id="HBH0029565.1"
                     /translation="MGKVIAVFNQKGGVGKTTTNVNLSASLGTLGKKILVLDLDPQGN
                     TTSGYGINKNEVENTIYEIMLDGLHIKEAIISTEFENVDVVPSATELSGAEIELTSKT
                     NREYILKNSIKAVIDEYDYIFLDCPPSLGMLTINCLTAVDSVLIPIQCEYYALEGVSQ
                     LMETIKLVKSRLNADIEIQGVVLSMFDGRANLSIQVVEEVKKYFKGSVYTTLIPRNVR
                     LAEAPSHGKPVIYYDKRCRGSVAYLELAEEFIDLEEEEW"
     gene            19638..20501
                     /locus_tag="KR257_000839"
     CDS             19638..20501
                     /locus_tag="KR257_000839"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429290.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ParB/RepB/Spo0J family partition protein"
                     /protein_id="HBH0029566.1"
                     /translation="MENKSKRSNRLGRGLSALIPEIKGETSEKEIVNIDIDKIYPNEV
                     QPRKQFDEEKIKVLSDSIKNYGVLQPIVVKMDENNKYMIIAGERRFRASKLANKNQIP
                     AIIKDIDMKDIMEIALIENLQREDLNSIEEALAYKSLIEHYNVTQEEISEAVGKSRPH
                     ITNTLRLLNLGQDVIEMIDSGRITAGHGKALLRIADKDLQLQIAKKIEEEELSVREVE
                     NIAKKISENKQEEPKKSKPKDVFILDVEDKLRNIFGTKVNISKGKKKGKIEIEYYNDD
                     DLNSIVSMLLE"
     gene            20534..21676
                     /locus_tag="KR257_000840"
     CDS             20534..21676
                     /locus_tag="KR257_000840"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892319.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aminotransferase class V-fold PLP-dependent
                     enzyme"
                     /protein_id="HBH0029567.1"
                     /translation="MIYLDNAATTYPKPERVYNAVLDCMKNYCANPGRAGHKLAMRAA
                     REIYDTRENIAKLFNVSNPMNIVFTSNATDSLNLAIKGVLQEGDHVITTSMEHNSVIR
                     PIKALEKRGIENTVVKCDYEGFLDYEDLEKSIKNNTKLIVTTHASNVCGTLIDIKKVG
                     EIAKKHNILFLVDASQTAGVYDIDVNECNIDMLAMPGHKCLFGPQGTGILYVREGLNL
                     NILKEGGTGSKSEEIVQPELFPDKYESGTHNTPGIAGLNQGILFIFERGINNIRQHEE
                     ELCQYMIDKLEEVPDIKIYGPKDSKKRASVIALNIGDMDSGEVTFLLDSDYNIATRSG
                     IHCSPLAHTTLGTLKQGAVRFSIGYFNTKDEIDKAVEALKKISKNK"
     gene            complement(21810..22385)
                     /locus_tag="KR257_000841"
     CDS             complement(21810..22385)
                     /locus_tag="KR257_000841"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898849.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GerMN domain-containing protein"
                     /protein_id="HBH0029568.1"
                     /translation="MKNKKIMLVLSILSISIFAVGCTNAQNGSDSSKKETKSNTNVEQ
                     PKEENNTEKEVPNNKAKPTPKEETKAQSATIYSFDVDKTDLIENKVDLNKIDENTLFE
                     ELQKLKVVPESAKLNSFTTKDIDGVKTGILDVSSDFTKSNLGSDAETLMLDSVARTYI
                     KNMNVEQIKITVDGSNYESGHIVLEEGDYLK"
     gene            22645..23937
                     /locus_tag="KR257_000842"
     CDS             22645..23937
                     /locus_tag="KR257_000842"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898847.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tetratricopeptide repeat protein"
                     /protein_id="HBH0029569.1"
                     /translation="MEILSLGEKIKKLRKEKNMTLKELAGDRITAAQISHIERDKSHT
                     SYELLEYLGDKLDVSVEYLLETKEMQSKKITDNLILQSEIYIKENELNKAEDQIKEVL
                     DICKRYDLMENYGRCNFLMANINLKKSNYNDAIENFEKALYFFIKNSDSENILKCYLN
                     IGKIYMQEDFYKGAISHFNFAEEILSESKFEDVNIHKELYSKMAYCYIKLDNPNMSLK
                     YIEKINEIDNRNDRKEDVDILVLKANNMLEIGKYEESRDYFKKALKILESEDNKTGLA
                     NVYLTICDVYRKIGETDRVLEYSQKVYDIKKNDEDEYMMSGLFKIIEAYIDKEDYDLA
                     RKYCKIALASSIKNKNKFNEYKALRFYANMYKNQNEVTLAIEYLIKCIKIVSDLGNNR
                     ILANLYIDLGQLYSNISKEKELEYYQKGVFMYKNLEIM"
     gene            24042..24644
                     /gene="yedF"
                     /locus_tag="KR257_000843"
     CDS             24042..24644
                     /gene="yedF"
                     /locus_tag="KR257_000843"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009906589.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sulfurtransferase-like selenium metabolism
                     protein YedF"
                     /protein_id="HBH0029570.1"
                     /translation="MSIKIDARGLACPKPVINTKRELDNLEEGVVVTIVDNETAKENI
                     LKLAKSLSCEANIVDEKENFISIEIRKGKNILDKQNVVDNKESELDNTCIFISSDKMG
                     LGNDELGKVLIKGFIYTLTESKPYPKYVLLVNGGVKLSAENEETIENLKILENMGVEV
                     LSCGTCLDYYNLKDKLQVGTVTNMYTIVETLKNASNTISI"
     gene            24717..24980
                     /locus_tag="KR257_000844"
     CDS             24717..24980
                     /locus_tag="KR257_000844"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434250.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3343 domain-containing protein"
                     /protein_id="HBH0029571.1"
                     /translation="MNQMYIVSFNSTHHAIRSEKLFGENSLKVMALPTPREITASCGI
                     SIKFSFEDMEKIKTILVENNVDIKGIYCISKLENGSKEVEKLD"
     gene            24995..25180
                     /locus_tag="KR257_000845"
     CDS             24995..25180
                     /locus_tag="KR257_000845"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898844.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF951 domain-containing protein"
                     /protein_id="HBH0029572.1"
                     /translation="MPMDLKIGDIVELKKQHACGCKEFEIIRTGMDIKIKCTKCSRLI
                     MLDRETLEKRVKKLIKK"
     gene            25283..26479
                     /locus_tag="KR257_000846"
     CDS             25283..26479
                     /locus_tag="KR257_000846"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429271.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PLP-dependent aminotransferase family protein"
                     /protein_id="HBH0029573.1"
                     /translation="MAVKYAKRMQGLQGSEIRELLKLTQQPQIISFAGGMPAPELFPV
                     EEMKKVSVAVLEENGRSAMQYTTTEGYEPLREKIAARMNDKNKTNVNKDDILVTSGSQ
                     QGLDFAGKVFIDEGDVILCESPSYIGAINAFKSYQPKFIDVPTDSDGMIMEELEKILE
                     TTDRIKMIYVIPDFQNPTGRTWPLERRKKFMEIVNKFEIPVIEDNPYGDLRFEGETLP
                     SLKSMDTKGLVIFLGTFSKIFCPGYRLGWTCASPEILSKFNFAKQGADLQASTISQME
                     VSKFMDMYDLDAHVDKIKAVYVKRRDVMLKTMEEEFPEGLVFTHPEGGLFTWVELPSN
                     LNAKELMPKCLDKNVAYVAGGGFFPNGGRENTFRLNYSNMPEEKIIEGIKNIAAVLKE
                     AMGVEA"
     gene            26693..26971
                     /locus_tag="KR257_000847"
     CDS             26693..26971
                     /locus_tag="KR257_000847"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420522.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S6"
                     /protein_id="HBH0029574.1"
                     /translation="MRNYELVYVVKPNSDEEVREAILNKVKEVVATDGEIVKVDTWGT
                     KKLAYPIAKFTEGFYVLVNFKSAVDVPKEIDRNLKINENVIRHMIVVA"
     gene            27008..27442
                     /gene="ssb"
                     /locus_tag="KR257_000848"
     CDS             27008..27442
                     /gene="ssb"
                     /locus_tag="KR257_000848"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420524.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="single-stranded DNA-binding protein"
                     /protein_id="HBH0029575.1"
                     /translation="MNQVVLVGRLTRDPELRYIPGTGTPVASFTIAIDRDYVKKDGSK
                     ETDFIPVEVMGKSAEFCANYITKGRLVALQGSIRVDNYQTQSGEKRTFTKVSTRSVQA
                     LDSKNKSENSYRESAPAFEPSFEPQGLDPQGFQAIDDDDIPF"
     gene            27461..27688
                     /locus_tag="KR257_000849"
     CDS             27461..27688
                     /locus_tag="KR257_000849"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420527.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S18"
                     /protein_id="HBH0029576.1"
                     /translation="MMNKKRRKKKRVCQFCADKNAKIDYKSTQRLQKYITERGKILPR
                     RISGTCAKHQRELTVAIKRARNIALLPYTLD"
     gene            27831..28151
                     /locus_tag="KR257_000850"
     CDS             27831..28151
                     /locus_tag="KR257_000850"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420530.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MazG-like family protein"
                     /protein_id="HBH0029577.1"
                     /translation="MKIDKGSEITRNIKIIEWMKTEILMSVSDLFNLLFKGVKPLDEA
                     IQDTLANIIMITYLLAKRLGISFRDVDYKVKEKIKIGIDEDHSVERWYGDLSNLKKHM
                     DNRE"
     gene            28159..29115
                     /locus_tag="KR257_000851"
     CDS             28159..29115
                     /locus_tag="KR257_000851"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434254.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YybS family protein"
                     /protein_id="HBH0029578.1"
                     /translation="MNNKIRLSKAMSIIVLAIIIALVIAYIPMLGIFSMLAAVPYVII
                     GAITDRKYSLISILVTFCVLILFADISYALNICIMYSLPGIVIGKMLKRSFEQEDSNK
                     FEPIYGGTIIFVLSMLVYFFVLKTFLNVNLLDEVSKMISEIVNIQKNSFSATELKVFD
                     KMKPDEIVSYFTNMLPMMLFLQGLLSAFVTYYLSVFFIKRITKMNIRFPKFADFYLPG
                     NAILTTFLLYLLVLFIQIIGSKLYTELIMTNLQLVFNLMFVIQGIAVCIYFLKKWIRQ
                     GPNKIMFFSGIILCLFGFMGISFVGMVDSIIDFRKVRSYKST"
     gene            29126..31120
                     /locus_tag="KR257_000852"
     CDS             29126..31120
                     /locus_tag="KR257_000852"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420536.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DHH family phosphoesterase"
                     /protein_id="HBH0029579.1"
                     /translation="MSNKQTFKLNMPEINLYIIVIGISSIILLYYNLYVGCLFFCIFV
                     YMVFHNWRTTNIRRHEWTEYIQNLSLDIDETTKKAIINLPIPLCILEFDGNISWYNGK
                     FYDMIGQKDLLDKNIEDIVKNLNLRKVLNENKEMYTEINYKEKEYTIIYNVIKNDQEK
                     NPKYLMILYWIDKTEYLKVKQNYDDEKNAMMLIQVDGYDEVLKSAAEDKRALINVEVE
                     KILSALELNSNGALRRTSKDKFFLVMHKKELKKLEAEKFSILDTIRHIDYGNNLPVTI
                     SIGIGIDGDTLNENLKLATGALDLALGRGGDQAVVKTKDKFVFYGGKSKAVEKKTKVK
                     SRLIGHALREVIQQSDQVYIMGHKYPDMDAMGAAVGVYDICKSCNKTANIVLQSVNES
                     IEIFINKINENNYYKKLFIGKEEAIDNCTKNTLVVVVDTHRPNYTECEELLKLSEKVV
                     VIDHHRRGVEFINDAVLLFHEIYVSSTCEMVTELVQYMDEDVTINKLTAEGLLAGISL
                     DTKNFAFKTGVRTFEAASYLRKVGADTIEVKKFFNSDVKDFIIKAEIIQSTKIINNRI
                     CLAYSSTEIDSINVIIAQTADELLNIKEVEASFVLGEKDDTIFISARSLGQINVHVLM
                     EKLGGGGHIDIAGAQLKNVSLKEAYKMVNKIIEEYLEEEE"
     gene            31121..31570
                     /locus_tag="KR257_000853"
     CDS             31121..31570
                     /locus_tag="KR257_000853"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420538.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L9"
                     /protein_id="HBH0029580.1"
                     /translation="MKVILLKDVKGTGKKGEMKEVSDGYARNFLFPKKMAVQADSVAI
                     KELNEKNKSKEIKAQKEYEEAVLLGKQMEEINIEIYSKAGEGGRLFGSITSKEIAEQL
                     KKQKDIDVDKRKILLDEPIRSLGSTFVEIKIHQKVTTKIRVDVKEKQ"
     gene            31589..32917
                     /gene="dnaB"
                     /locus_tag="KR257_000854"
     CDS             31589..32917
                     /gene="dnaB"
                     /locus_tag="KR257_000854"
                     /EC_number="3.6.4.12"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429266.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="replicative DNA helicase"
                     /protein_id="HBH0029581.1"
                     /translation="MEDMTRIPPHSVESEQSILGSILLDKDAIITVTETIKPDDFYKE
                     AHKIIYECMITLSNKGEPIDLITLTEELRKQGHLNDIGGISYITSLSTIVPTTSNVKY
                     YADIVKEKSVLRKLIKASNEIINLGYSGATKIEDVLEQAEKSIFDISQEKTSDDFKSI
                     NLVLMDAYDMIEKLYTNKSDVTGITTGFKDLNKKINGLQRTDLILIAARPAMGKTAFS
                     LNLVQNAALKGDASVAVFSLEMSKEQLVQRMLSSQSSVELKKIKTGTLNDNDWPRIID
                     AMAVLSDAKIHIDDTPGIKISELRSKCRKLKIEKGLDLVLIDYLQLMEGEGNNESRQQ
                     EISKISRSLKILAKELNCPVVALSQLSRAPEQRADHRPMLSDLRESGAIEQDADIVMF
                     LYRDEYYHADSESKNIGEVIIAKNRHGETGSVELVWLGEVQRFGDKLRDL"
     gene            33122..33430
                     /locus_tag="KR257_000855"
     CDS             33122..33430
                     /locus_tag="KR257_000855"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011862026.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0029582.1"
                     /translation="MEKISLKYIYPNIIKVLDEINLFRVIDNNLRESIVVYANNVDNQ
                     YHINMTNTNFGNIINICKLEKLLDVDKFMEKVIKYEKEIIEKEEFSKIEEYMLNIGEY
                     "
     gene            33512..34801
                     /locus_tag="KR257_000856"
     CDS             33512..34801
                     /locus_tag="KR257_000856"
                     /EC_number="6.3.4.4"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420547.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="adenylosuccinate synthase"
                     /protein_id="HBH0029583.1"
                     /translation="MKTVAIVGSQWGDEGKGKVIDYLATQADVVVRGQGGNNAGHTLV
                     VEGKKYALHLIPSGVLNPNTVNIIGNGIVFDPKGFLEELEMFKTDNISTENIKISDRA
                     HVIFPYHKELDALSEEARGDLKIGTTKKGIGPCYMDKTERSGIRICDLMDKDKFAIKL
                     KAQIDAKNEIVKNIYGKEELFDFETIYNEYLGYAEQIRKYVADTSVIVYDAVRAGKKV
                     LFEGAQGTLLDLDLGTYPFVTSSHPTSGGFAIGAGIGPNMIKDVVGIVKAYTTRVGEG
                     PFVTEQINETGDKIREQGHEFGVTTGRPRRCGWFDAVIVKYAARVNGLTSISFMLLDV
                     LTGFDKIKVCTSYKMGDKIITDFPASLDDLAKCEPVYEELDGWNEDITQIDNFDDLPE
                     NAKKYVAKIEELVGVSVDMVSVGPNRAQTIIRRNIFA"
     gene            35127..35202
                     /locus_tag="KR257_000857"
     tRNA            35127..35202
                     /locus_tag="KR257_000857"
                     /product="tRNA-Lys"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:35160..35162,aa:Lys,seq:ttt)
     gene            35209..35283
                     /locus_tag="KR257_000858"
     tRNA            35209..35283
                     /locus_tag="KR257_000858"
                     /product="tRNA-Glu"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:35242..35244,aa:Glu,seq:ttc)
     gene            35288..35363
                     /locus_tag="KR257_000859"
     tRNA            35288..35363
                     /locus_tag="KR257_000859"
                     /product="tRNA-Val"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:35321..35323,aa:Val,seq:tac)
     gene            35397..35471
                     /locus_tag="KR257_000860"
     tRNA            35397..35471
                     /locus_tag="KR257_000860"
                     /product="tRNA-Thr"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:35429..35431,aa:Thr,seq:tgt)
     gene            complement(35854..36846)
                     /locus_tag="KR257_000861"
     CDS             complement(35854..36846)
                     /locus_tag="KR257_000861"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892306.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding protein"
                     /protein_id="HBH0029584.1"
                     /translation="MNEDKIRKILAKYAKRRDDNELLLEHRKNEVYNRIPEIKSIDDE
                     ISKIGLSLAKIVLLNPKSKDEIVKKTKENIESLKVKKERLLAESNIPLDYLEIKFQCI
                     SCKDKGFLPNGEKCSCLKQEIVNEAYKMSNLDRILSQENFSNFNLNIFSPKKGSDGEI
                     SPRENMLNNLSICENFVHDFKKDNSENLLFYGSTGLGKTYMCNCIAKELLDKGNVVIY
                     QTSFRILDILEDYKFRRDTNNQISEDNYKNLFDCDLLIIDDLGTELNNSFTSGEIFNI
                     VNTRLVAGKKIIISTNLTPSQIGNTYTQRTLSRILDKFRILEFTGDDLRWERFK"
     gene            complement(36855..37913)
                     /locus_tag="KR257_000862"
     CDS             complement(36855..37913)
                     /locus_tag="KR257_000862"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420554.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DnaD domain protein"
                     /protein_id="HBH0029585.1"
                     /translation="MFFKESNEIDLGEITIPNIFIDIFMPMADGLYVKVYLLGYRQAC
                     DITSNPKFDNNSIAKNLNIPLSDVLSAWKFWEEKKIIKIHDNEEYDNFNYSIEFLDLK
                     NFYIENILSNNSSIKSNTDKVVSTSENPSIRKMFNSINKIVGRYLDPSEKMSIMDIMN
                     KYNMSPDMILCAYEYVKDKTGTSKPVKYIEGIIRNWYDSNLYTPKDVEESFLVRSERY
                     ILYKTIFNELGFSRQPSKSEKELMDTWFDKFNMDIDLIINACSKSKNISNPSISYING
                     IIKNWNEKNIKNLNDLKQKEEERIVKENINKKQINTTQNNNTYKKTKFHNFNETFTQY
                     TSDELDEIIKKSQKEKFK"
     gene            38038..39501
                     /locus_tag="KR257_000863"
     CDS             38038..39501
                     /locus_tag="KR257_000863"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420558.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="M1 family metallopeptidase"
                     /protein_id="HBH0029586.1"
                     /translation="MVIKFNQKVRRTLSVAILFMVLIIGCFIEKDDSLETYKEKTNSK
                     INQYNMDVIFDDETKRLMCNQNVDYINNTKSNIDKIYFHIYPNAFSKKDFAPFEKSEM
                     TRAYPNGFNEGYIDIKNILNNNSKMEYKIKGDKNDILEIELGKELKPNERMSLDIKYN
                     VKIPNSIGRFGYGENTINVTNWFPIACVNDERGWNLKSYETIGDPFYSETSDFHVKLL
                     IPNKYKIAHTGKLIDDKHDNKKMLYEIEAENVRDFAFILSSKFDVNKVDSKGVAINTY
                     NLNKKLSKKATEVAKDSINIFSELFGKYPYKEFSVVASDFFIGGMEYPMLVMIDQSLY
                     NEKNEFLLEYVIAHETAHQWWYSAVGNDEISEPWLDEALTEYSTIVYFEQKYGKDMAN
                     KLIKTMEIQTKSYLSENIFKPANEYKNSTEYSLNVYTKGAIAFNEIRKEVGDKVFFET
                     LNEYYNKYKHKNANGRAFVELWNSKGVDINKIISECK"
     gene            39603..40400
                     /locus_tag="KR257_000864"
     CDS             39603..40400
                     /locus_tag="KR257_000864"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435698.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MBL fold metallo-hydrolase"
                     /protein_id="HBH0029587.1"
                     /translation="MLKYCSVGSGSSGNCHYIGYKNTNILVDAGLSGKRITTGLKDIG
                     VDADKLKGIFITHEHVDHIKGAGILSRKFDIPVFANIKTWCSMKDKLGDIKDKNMKVF
                     ENDKTYSLGDIIVRPFSIEHDASDPVGYNFYTESDEKMSIATDIGCITQNIKKHLYKS
                     KLVVLESNYDPNMLMMGSYTYALKKRVMSSTGHLSNEDAANFCVELINEGTESILLAH
                     LSKENNFPELAYETSKGVLASNDIVVGQDVKLDVLSRNDVSNVYEMK"
     gene            40413..42515
                     /locus_tag="KR257_000865"
     CDS             40413..42515
                     /locus_tag="KR257_000865"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429254.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIC/EAL
                     domain-containing protein"
                     /protein_id="HBH0029588.1"
                     /translation="MLKRNFENVEDNKILYSIKQGMILAIPAIMTGSTALVILNLPIK
                     AYQEYLSGLFNGEVTNILNFINDSTLGIISLIILLTISYSYGKIYGSKYTVLVPIVAM
                     CSFLVFSHGNELNSYIEIFKTKWLFTSIIVSMTSSVLFVKLTESFVTSVKFHTEGADA
                     DFNMVVSAIVPFIIVVFLFSIFRVVMISLIGSSNFQDIFYNLFSNVFNKMGTNLMSAL
                     LFIFLMHFMWFFGIHGSNVLDTVAKNLFENSMAININLVNNNQLPTEIFTKTFFDTMV
                     LLGGCGSLLCLVIAIFLSEKRINVRKLAKIASIPALFNINEMLVFGIPIVFNYIMFVP
                     FVITPIILTVTSYVAMSTGIVPCTVSAVEWTSPIFLSGYMSTGSIRGSLLQVFNLCVG
                     VMIYIPFIKMSQNRYTYMFKNNIENLTNLLKRYELTGEQPNLLNHNGKIGSISKMLAS
                     DLKFAMKRGEIELFYQPQVNYNGNVVGAEGLLRWKHSIGGFIYPPLVIILAKEEGFLD
                     ELGEYIINKACIDLKKSEKLLRNPVKFSVNISPDQLDDPKLPEQIKNIISSNDINPNM
                     LGIEITEQIALSGSQIIIERINAIHNLGIKLIMDDFGMGHSSLIYLQNNNFDIVKLDG
                     SLVKEILTNKRSSEIIMTIVNLSKNLDFDIVVEYVENIDQRDKLYGLGCEIYQGYYYS
                     KAIPFEEFVEYANQEREI"
     gene            42583..43062
                     /gene="rlmH"
                     /locus_tag="KR257_000866"
     CDS             42583..43062
                     /gene="rlmH"
                     /locus_tag="KR257_000866"
                     /EC_number="2.1.1.177"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001027003.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="23S rRNA
                     (pseudouridine(1915)-N(3))-methyltransferase RlmH"
                     /protein_id="HBH0029589.1"
                     /translation="MNISIVVVGKIKEKYLKLGIDEFKKRLSKYCKLEIIELDDEKAP
                     ENLSVKEMEIIKDKEGKKILGKIKHNSYVIALAIDGKGLSSEELAKTMSDLAVRGNSS
                     LCFIIGGSLGLSDEVLGRADYRLSFSKMTFPHQMMRLILLEQIYRAYRINNGEPYHK"
     gene            43211..43522
                     /locus_tag="KR257_000867"
     CDS             43211..43522
                     /locus_tag="KR257_000867"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420570.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIB"
                     /protein_id="HBH0029590.1"
                     /translation="MIKIMLACSAGMSTSLLVTKMESAAKENGIESQIWAIPESTIQN
                     EIEKCDVLLLGPQVRYVLPKAQEIAKPYNIPVEVINMMHYGTVNGEAVLNRAIELNNT
                     K"
     gene            43570..43887
                     /locus_tag="KR257_000868"
     CDS             43570..43887
                     /locus_tag="KR257_000868"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435715.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS lactose/cellobiose transporter subunit IIA"
                     /protein_id="HBH0029591.1"
                     /translation="MDEKTIEISFNIIGYAGEGKGLAFEAIKEAKNGNIEKAKELLKE
                     SREVINKAHRYQTELIQNEASGNRTEISVILIHAQDHLMNGMNFQQLAEEIVDLHLKL
                     QDK"
     gene            44100..44801
                     /locus_tag="KR257_000869"
     CDS             44100..44801
                     /locus_tag="KR257_000869"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435717.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GntR family transcriptional regulator"
                     /protein_id="HBH0029592.1"
                     /translation="MLRNQPLYIQVVDILKQKILNNEYKIDENIPTERELEQEFGVSK
                     ITIRKAIEILESEGYVEKKSGKGTKVISNSLFNKLSKAESFSSILLSKGHKLSKKTIS
                     IEKIINDTNSQVFSIFGEKCSKITRMYYLDSKPYIFFTHYIPFDENLTVESFNNESSL
                     YMYLYRRNINITRFEDEFFIEESELEVSKALNLAKDILLGRKRKTYDENDNIVELSFA
                     RYNTEVQNYVIKYEI"
     gene            45025..46326
                     /locus_tag="KR257_000870"
     CDS             45025..46326
                     /locus_tag="KR257_000870"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892292.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIC"
                     /protein_id="HBH0029593.1"
                     /translation="MEKFASFLERKIMPVAAKISNQRHMRAVRAGIIATLPLTIVGSF
                     FTILLNIPIDAYMDFIAPFKAILDIPFRYTVGFLSLYATFGIASSLAKSYDLDTTGVG
                     MLAVMAFLVSTIVPTQVVEPVGGVIEAGRWMDMAKLNSPSLFGAIVTSLITVEIYRFM
                     KEKNITIKMPAGVPVEVSNSFTALLPTAVILMLFWVIRHILGFDISVALSAMLSPLKG
                     FLSGNSLGGGLLTVFLITLFWVLGIHGPAIMGPVIRPIWDMSIAENITAFTEGVSAHA
                     MPNIFTEQFLQWYVWIGGAGATLALVVMFMFSKSQYLKSLGRLGFLPGLFNINEPIIF
                     GAPIVMNPILGIPFIIGPIIMTILSYVLTITGVIPMMVARLPFAMPAPIAAVMSTNWS
                     ILAGILVLINFVISFAVYYPFFKVFEKQQLQREQEEMSENL"
     gene            46463..47557
                     /locus_tag="KR257_000871"
     CDS             46463..47557
                     /locus_tag="KR257_000871"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892290.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF871 domain-containing protein"
                     /protein_id="HBH0029594.1"
                     /translation="MERRLGISVYPEHSNMEDDKAYIKMASKYGFKRIFMCMLSITRP
                     KEEVKKHFKEIITYARELGFEVILDIAPNIFDILQISYDDLTFFSELNASGIRLDYGY
                     DGSKEAMISFNPYDLKVELNMSNDVAYLDNIITYKPNVNNIYGCHNFYPQRGTGLPYD
                     FFVRCSNRFKKYGIRTAAFVNSKYATIGPWNINDGLCTLEMHRNLDIATATKHLFATG
                     LIDDVIVGNAYASEDELKRMSEVNKYQVVFNVVTEEKTSEVEKTIMANEQHFRRGDIT
                     NQVARSTEVRKKYAKENFPKHDNTTIFKRGDVVIGNDDFGKYKGELQLILQDCADERK
                     NKVGRIKEDEIMLLDFIEPWSKFKLILEGE"
     gene            47559..48692
                     /locus_tag="KR257_000872"
     CDS             47559..48692
                     /locus_tag="KR257_000872"
                     /EC_number="3.5.2.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892288.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amidohydrolase/deacetylase family
                     metallohydrolase"
                     /protein_id="HBH0029595.1"
                     /translation="MKIDILIKGGKTVDKSIIDIAILDDKIIEVKNQIDDSKYQANQI
                     INLDGEKFISAGWIDIHTHCYERLDLYKDYPDEVGIKSGVTTVVDAGTTGALDIGKFY
                     EDTKKYKTNVYALINIAKQGITSQDELSSMMNIDEYELKRAVKKYKDFVVGIKARMSK
                     SVVISNDVEPLKVAKRIKNELNLPMMVHFGSSPPTIEDIFDYMEKGDILTHIYNGKPN
                     GILRGNEVKKEIIEARERGIILDVGHGTESFSMDIAMKSKDAGIFPDTISTDIYIKNR
                     INGPVYNLSTTMEKFIYMGYSLEDIIDKVTKNAADAISLKNKGLIKEGYDADLTIFDV
                     VNEEKELQDSLNKSVITSTSIKPRAVVVNGEYLNIGKSIGENE"
     gene            48710..49819
                     /locus_tag="KR257_000873"
     CDS             48710..49819
                     /locus_tag="KR257_000873"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009894111.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DgaE family pyridoxal phosphate-dependent
                     ammonia lyase"
                     /protein_id="HBH0029596.1"
                     /translation="MSSIFEKYSVRRVINASGKMTILGVSTVDKEVIEAIGEGCKNFF
                     IIEELINKTGEYIANLLGCESALIVSSASAGIAQSVGAMIAKDDMSLVYNVNNPKKQV
                     KREIIIPKGHNVDYGVPVEVMIRLGGGEVVEAGYANMCNKEHIIREINENTAAIMYIK
                     SHHCVQKSMLSVLDAVQVAKEYNLPLIVDAAAEEDLNVYYELGADLVIYSGAKAIEGP
                     SSGLVIGKKKYIDNVKLQSKGIGRAMKIGKENIVGLTCAIERYISNDKVTLKEMEDKL
                     NPFIDKINTIKGVSASITRDSAGREILRGEIDFNEDIINKSTQQIINELRSGEIAIYT
                     RDYKANEGKIEIDIRSVTGSDLDTIYNRIKNIVES"
     gene            49884..50624
                     /locus_tag="KR257_000874"
     CDS             49884..50624
                     /locus_tag="KR257_000874"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729158.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="KDGP aldolase family protein"
                     /protein_id="HBH0029597.1"
                     /translation="MNCIPQYYKNRVCLNVLAGSIKNAKEVYDACDGYVLIGVLSKNY
                     STVEAAIEDMKKYSKEIDNAISVGLGAGDPNQSNMVSQISKELQPQHINQVFTGVATS
                     RALLGQNDSIINGLVSPTGKPGFVKISTGPLSSKEKDGIVPIETAIAMMKDMGGSSIK
                     FFPMGGLKTKDEYIEVAKACAKHNFYLEPTGGIDLDNFKEIVQIALDAGVEKVIPHVY
                     TSIIDKETGETKVEDIGVLYKIMKELLG"
     gene            50629..51621
                     /locus_tag="KR257_000875"
     CDS             50629..51621
                     /locus_tag="KR257_000875"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429232.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sugar kinase"
                     /protein_id="HBH0029598.1"
                     /translation="MNILAFGEIMMRLSVPDYKFLTQTNELNYIITGTGLNILSGLKN
                     FGYNTYMLTKLPNNNVGKASSANIRKLGVKDDFITYGGNHIGVYFLENGYGERPSEVT
                     YLNRLNSSFCESKLQDYDIDKCLEEMDIVLICGIAMQLTDSIKEIALELARKSYEKGI
                     KVFFDFNFRQSLNPERTYDDLVNDYKKILPYCHGLFASYRDINKILNIDSLNIKSSSE
                     LIKKEYDIGIVAGTMRRFDDMNNRFIKGYISNDDGYFESREYKLEIYDRVGAGDGYVA
                     GIIYSYLENMKSEDIVEFGVASSVLAHTTYGDNSLVSTGHVLRLMNNEKIDILR"
     gene            complement(51809..52690)
                     /locus_tag="KR257_000876"
     CDS             complement(51809..52690)
                     /locus_tag="KR257_000876"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429230.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LysR family transcriptional regulator"
                     /protein_id="HBH0029599.1"
                     /translation="MNTKQLEYFISVAENLSFTKTAEKFYISQTAVTQQIKALEEQIN
                     VTLFTRSKRHVELTPAGKVFLSEARTIIKNINDAIAKTQQFAHGFFGTLSIGTLIGYE
                     KNKLQQYLKEFSNTYPNISMDICTNEITELLNLVKNNSMDLAFVINPENQPLKDFEYK
                     TVERYSLVALLPPGHPLYNEDSIDLIELQHDKFIFVKETGDEYGQKSMIQNRYREAGF
                     VPNVVQRSNNLNTIESLVSSNMGISILPSFCVTDTMIERDIAIVPIKEVENRIEVVVV
                     WNKKNTNPALEKFISII"
     gene            52963..54351
                     /locus_tag="KR257_000877"
     CDS             52963..54351
                     /locus_tag="KR257_000877"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729155.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0029600.1"
                     /translation="MEDKFYAKGNGNNGYIKNLEVCSFNNLDGTCGMFQMALYKRDEK
                     YYLYGCCFGGNKKNGVMISDITDPYNPQFIKHFQMLDPKEYPTTTTPKIQIADDLMIV
                     AMSCGSGPGALVDQAKLANIKCEAGIRIYSLKEDPLNPKFLGYWDCGLKHVMGVHRFM
                     YNGGRYVHLSSDCVGFEGLIYRVIDIINPTNPVEIGKWWRPDQYADGYPNRTFDAGAP
                     HCPEFMDKGWLHGPPFVRDGKAYCGYGGAGLVVLDVEDLTRPRCLGELPFMPAFSSRL
                     AGARTHTALPLPGRDLVVVQNEGERFQFFKPDNITDVQAMNNIHMVDVSDPTKPTLIA
                     QFPYPEVPKDFPYPNFNVAGLGKPGPFGPHNLHEPMDNKPWLEQRGDRVYCCYFHAGL
                     RVYDVSDPYYIKELAYFIPPNPNKTPEESYFPGFPGPRLAVTEDLIVDDRGYIIIDAL
                     DDGFYILKMKED"
     gene            54379..55332
                     /locus_tag="KR257_000878"
     CDS             54379..55332
                     /locus_tag="KR257_000878"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729154.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NAD(P)H-dependent oxidoreductase"
                     /protein_id="HBH0029601.1"
                     /translation="MKILGISFGTKNGNNDTMCKVALKGAKEAGAEVEFIQMSSINIK
                     HCTGCCACVKTLLSGKGSMCVLKDDFEWLLDKMKDADGIVVSDPIFEEGASGLFHTIM
                     DRFGPRADRGNNIIGTKVAEAIGGKIPDSRMLNDKVISFMGIGGSDWGTRVQCEHAML
                     ALIPMWKVIDNAWFPWAKELVMDDTRLVQVHQIGLNIVEAAKDFEKASYQGEEGVCPH
                     CHNRLFYLEPGTKKAICALCGIVGELDTISGKTIFSFPEEQLGHAHDTLPGKFIHGDD
                     IKKMEGHYAEVRKTQEFKERKTSYNFIETLTKEKQAGVSLG"
     gene            55392..55616
                     /locus_tag="KR257_000879"
     CDS             55392..55616
                     /locus_tag="KR257_000879"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429224.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0029602.1"
                     /translation="MNEKPSFKQIEVILAVIFLVLTYYKVRLTPAFIVIFIPLYLSYF
                     AVSMIVNQIAIKLLEIRQAREATNYNIGNG"
     gene            55609..56121
                     /locus_tag="KR257_000880"
     CDS             55609..56121
                     /locus_tag="KR257_000880"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009894099.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1097 domain-containing protein"
                     /protein_id="HBH0029603.1"
                     /translation="MDRKKKEILTLSMGIALLPPLWAVLAPYIGIKTGAVALICAGLY
                     VTNGNKQEDGLKIMFGFWCGDLWAVLVILIMGYMNFNQNLELFLTLSILGFFAVVIAS
                     LFEKIIFLPSWLCGWAIGLTIMTGENIINLQDICIQIAVAMAVGVWYVGAGVDLFTIY
                     ILSKDRKKGN"
     gene            56153..57007
                     /locus_tag="KR257_000881"
     CDS             56153..57007
                     /locus_tag="KR257_000881"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011862019.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="acetyl-CoA hydrolase"
                     /protein_id="HBH0029604.1"
                     /translation="MAMGFEFKIMRSLIYVGLAKEEYRPKLMDWLYRHHIPDSISTFG
                     PYCTKYAFYQAYPTPNEGERFGARKMQLTEHYWLVDEHMPEMANRIMTEYMPMDVLRW
                     QGCIPDVENKRVHENAESGDAGRAVGGDNGCPPFIFAFVPINWEEDFRGKGRTVQDGP
                     NYRWQFMIKYPDGISKEEGEKWFYDEVVPYFTNCCYVNRFVSSKIMINYGATAFDRVS
                     ELWFEGEEEWYKAVVEETKSFIKKPEWAQEEEFPYLKPQFNIASVFLGDIATMDAYSQ
                     YRGYIPMR"
     gene            57541..58335
                     /locus_tag="KR257_000882"
     CDS             57541..58335
                     /locus_tag="KR257_000882"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435749.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MerR family transcriptional regulator"
                     /protein_id="HBH0029605.1"
                     /translation="MYTIGQVSKFLGISRDTLKFYEDKGLVNPKKNDENGYRIYNQVD
                     IYDIATINFYREIDIEIKKIQEIRKSKSINNLELLLEEKEQIILKEIEYKKLLLKKVQ
                     LVKEDCDKIKTYFGKYTIKEMKPLEVKGKIKHVTNYEEYEALKENTNNLKKAVTLTDL
                     RRVINFNEEGIIEEKFIIVREVDDYNKIIEGEVLSHPNCIYTIIEDGRWSTGGENIDN
                     KVEDRLREIAIENECELLGIVYVNILLTTYEEGIERIFLEIYAPIK"
     gene            58439..59245
                     /locus_tag="KR257_000883"
     CDS             58439..59245
                     /locus_tag="KR257_000883"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011862018.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CPBP family intramembrane metalloprotease"
                     /protein_id="HBH0029606.1"
                     /translation="MRTEKSLKRPIASFIILTNIIFLPLFLLVVVTIMLKLPTVISDI
                     ALCISAWSSTFAFMILFKKIYPGKKFLVHVKDRFRNKLKFSTVSIIISIQVLIAVVVI
                     FILASKNHGIMPNFTVSSWGAFIYLFLKNLFAGSLGEELGWRGFVQNHLQKRHSPLKA
                     SITVGFWWGMWHLPIWFTTGFKGLDLIKYIIFFMIAIISISIIMTTFYNLNKTLIIPI
                     AIHQLFNFLIGIINEDLIELINYYAMLYLIFAIALIVINPGNVLYKNIRE"
     gene            59307..59828
                     /locus_tag="KR257_000884"
     CDS             59307..59828
                     /locus_tag="KR257_000884"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003374619.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cysteine hydrolase"
                     /protein_id="HBH0029607.1"
                     /translation="MVLLIVDAQKLITNERLYKFNEFVVNVENLIDTARKNNIEVIYV
                     RHDDGVENELTKGKNGFEIYEKFKPCNGEKIFDKKVNSAFKETGLLEYLTNNGEKDII
                     IAGLQTDYCIDATIKCGFEHGFNIIVPAYSNTTVDNFFMSAEQSYKYYNEFIWNERYA
                     KCISLEETLRKMK"
     gene            60243..62330
                     /locus_tag="KR257_000885"
     CDS             60243..62330
                     /locus_tag="KR257_000885"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011862017.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcription antiterminator"
                     /protein_id="HBH0029608.1"
                     /translation="MVVDKEIVSILQILLNSTLITTNGLQEESNSSKRQITYRINKIN
                     DMLKVKNVPLICLRADKDIIVRKETKKAIKEILEKNYSKNTYYFSKTERLLYMYLMLF
                     INMEDISINHFINSIKVSRSTVNLDFKDLIPELEKKNIKVKNNRINGYYIVGNEMEIR
                     RVLIKNIIETLSNEKSSRVFDIFIKEYNLDSFEEAKKIILKLIKKYEITFVEDRLIEF
                     IYIFIFLKARMYSTRIVTQENVDIPNISVMSSMKEYKFAKELLEVYGSEDKIKPHNIM
                     YISAWILGISVGNYEEDTEDKDVISKIVNKMMTKFGYLSGVYYISQEKIFKQLYSHFR
                     PAYYRLLFKLPIYNPICEKVKEEYKLVYRIVSNAMKEFCGLFGEEIQEEELAYLTMHF
                     ATLFSNKKEFDGFRKRIALIVCSNGVGSSAILHAELTNLFPDLHFIPMSESVGLENIS
                     EPVDIVFTTNYNAEGLKTDVPVIKVSPVMTTKEKYKITREVYIQLGDIFLRQPKIDEV
                     MDIIKKYANVTSESILSSELLAYFTQIENFTSKEGEGPMLSEITNETLVKIKVKAKNW
                     EEAIRQSASVLVENNKVTEGYVDAMINSAKASGPYIVITKHVALPHARPEAGSKEIAI
                     GIATLDSPIEFGNNENDPVKYVFCLSAIDNNSHLRAMSELVELLEEDEFFKVLDSAKE
                     AKEIIDFIKTHEL"
     gene            62345..62632
                     /locus_tag="KR257_000886"
     CDS             62345..62632
                     /locus_tag="KR257_000886"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420619.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIB"
                     /protein_id="HBH0029609.1"
                     /translation="MYKILIACRAGVGSSLMLKIKTQQIIKENNFPIEVEHGSLDSLN
                     GFNGDAVETLIDVAEELKNKNLKFDIIGIHNIVDRNEIKTALEKFLASKEG"
     gene            62659..63930
                     /locus_tag="KR257_000887"
     CDS             62659..63930
                     /locus_tag="KR257_000887"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420622.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS transporter subunit IIC"
                     /protein_id="HBH0029610.1"
                     /translation="MEFIISLLSTPAVLLGVVACIGLILQKKSAVEVFTGSSKTLIGF
                     LIFGIGASAMTGALQNFNKLFQHGFGITGVIASPEAATALAQGTYGFAVSCTLILGFI
                     LNLVFARITKFKNIFFTTGHSLFFSCVLVLIMKAHGFDNTITILIGGTILGFMSAALP
                     QFCQPFMRELTGGDEQAIGHFNMIGYGLSGYIGRLFSKHKDDTTETIEFPKWLSIFRD
                     FLMGLSIVMLILFYIATLKAGQAFTQEIAGSTHWLVFPLIEAFTFVAGMSILMSGVRM
                     FLAEITAAFVIISEKYIPGSRPALDVPTVFPYAPNAVIIGFISAYAAGLLAIAIMASF
                     PSIFPVVIIPAAHICFFSGGTAAIFGNTSGGWRGAIAGSFVVGLLLAFLPVILYPVYG
                     TLGIEGATFPNIDYNVVGSILHNILQFIKPI"
     gene            63988..64587
                     /locus_tag="KR257_000888"
     CDS             63988..64587
                     /locus_tag="KR257_000888"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429210.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SIS domain-containing protein"
                     /protein_id="HBH0029611.1"
                     /translation="MENTLSEFLDNISNELSEFIASIDETSINKACELILEAEKNHGR
                     VHVTGIGKPGHVSGYISSLLSSTGTSAYILHGTEAVHGSSGQVVEGDVVIAISNSGET
                     QELKATLKTLKVNGAKIIGVSGNESSFLKNISDIFLFAGVKQEGDCLNKAPRASILAE
                     TIILQSLSVVLQYAKGLNTQQYLKWHPAGSLGKSIREGI"
     gene            64592..65497
                     /gene="dapA"
                     /locus_tag="KR257_000889"
     CDS             64592..65497
                     /gene="dapA"
                     /locus_tag="KR257_000889"
                     /EC_number="4.3.3.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009894092.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="4-hydroxy-tetrahydrodipicolinate synthase"
                     /protein_id="HBH0029612.1"
                     /translation="MKYKGIICAMITPFDENQNINSQATCQLIDYLIEKGIYGLFILG
                     TNGECHVLTDDEKVEFAKIVINHTNNRVPVFVGTGGNSTREVVDLSKRMEAIGASALS
                     IITPYFVTPTQQELILHYKTIANSVNLPIIMYNMPSKTGINIEPESVRELSKIKNIVG
                     IKDSSGKLDNMKAYIEATKNENFSVFSGSDSLILDSLKAGSQGAVAATTNFLTEIGIS
                     IYENFMKGDLEEAQKAQSSIEELRRILKLGTIPSVMKKTIVLNGINVGTARLPVTEPT
                     GEVLEEIKRVVENYRTILNKSSENR"
     gene            65603..66235
                     /locus_tag="KR257_000890"
     CDS             65603..66235
                     /locus_tag="KR257_000890"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892267.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ketohydroxyglutarate aldolase"
                     /protein_id="HBH0029613.1"
                     /translation="MKKMNITKRMSECGALAIVREENLNRACEIAEGCIKGGITVIEM
                     SYTLNNAGEIIQGLNKKYGETLCVGAGTVLDSETARHAILHGAQFIIAPNYNECVAKI
                     CNRYQIPYAPGCTSLTEAVDALSLGATFIKAFPISDFYGPKLVKVFKTPIPDMPVLAS
                     GGINIENLHIWLENGVDVCGFGGLLTKGSVEDIAKNAKKIREIIKNIRKI"
     gene            66713..69220
                     /locus_tag="KR257_000891"
     CDS             66713..69220
                     /locus_tag="KR257_000891"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011862014.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="diguanylate cyclase"
                     /protein_id="HBH0029614.1"
                     /translation="MKEDIRLHRMCKKEQATKNEVISEDILKSMSIGVSKHFLDDSFT
                     IIWGNTSFYQLLGYTEEEFLVKFSSLKDYYEQNLYHFESMKNHFLEAYHHGEKSIEYQ
                     ICISANNGDPVWVIMTGILIESQDNEKSMVYILYSKINELKIKQEELSDMEKESTENF
                     KWMMSEYAGNVYISDMDTYELLYLNKHSCNTLQASANELIGRKCYEVIQGRTSPCPFC
                     TNSYLKKDDIYEWEFYNKKLKRTFIIKDRMLNWQGRRVRIELSYDMYSAEYKLAKKDQ
                     ERESILKTIPAGMVRLDARDYLTILWCNDIFLNMIEYTKEQFAEELNNQCGYLFSEDY
                     KRSKKLAQDLKESGDNVVFEAKIYTRSREERIWTVTLCYISGEDSWDGIPSFYSIGID
                     ITKERKQIEKLQHISEKDALTGIYNRAETERQIKKYFEKNLNVMGALFMIDTDNFKQI
                     NDTEGHMIGDIVLTEMASGMKKIMRDSDVVGRIGGDEFTIFMKNISSVKDAEKKAEEL
                     LYMFRHLFQKEKSFLKVTCSIGIAIYPKDGTTFKEIYARADKALYQAKNMGKNNYVIY
                     NQDYFKELEEFDCSSLGTVIDSEKQYAEYPDNLTRYIFRMLYQTDDIDQAINMILEVV
                     GKQFDVSRVYIFENTEDGRYTSNTYEWCNEGISSQMAYLQNSNYQDYEDYEKLFEDEL
                     VFYCRDIHTLSPKLEELFSSQGIHSTLQCAYKEDRVFSGFVGFDECTGLRLWSQEEIS
                     TLSLISQIISMFLQRKKNNKLNQQIQQYQNILDNIDQCICVINKENNFLLYVNKKFKN
                     TYSKFQIGQPYYLDSIDIHKISIIWNKKEAYLCTSTI"
BASE COUNT        26464 a         8353 c        11675 g        23127 t
ORIGIN      
        1 atataaatta acctactgtt taattttcaa tgttcgtgtt tatttcttgt tccttttttc
       61 aaggacaagt aatactatac catctttaaa acagtaggtc aatacttttt ttatattttt
      121 ttataaattt ttttcatatt cttttttcag cttctctact acctttttct ctagtctaga
      181 aacagtcatc tgtgatatcc ctagttcttt agctatacta gattgtgttt tatcaaagaa
      241 aaatctatct ttaaaaattt taacttctaa ttcatttaaa gtttcaataa acttattaat
      301 aaaatcttca tactctatac ttccaaagtt accttcttct tttccaatct tatcaataag
      361 agttatatct ttatcctctg aatcatcatt acttgatgaa tccaaagaca ttggttgata
      421 tccataagaa gcctccatag cctctaaaac atcttcttca ctaacgccta tataatcagc
      481 tatatctttt acctttggat gcttcttatt ttcttgttct aatttaatct tcgcatcact
      541 tatctttttg cttaattcct gtattcttct tgggactcta agtgtccata ctttatctct
      601 aaaatacttt tttatttctc ctactatagt tggtgttgca aagctggaga actcaaatcc
      661 tttctcaaca tcatatctat caatagcata aattaatgcc aatgaagcaa cttgatatat
      721 atcttcaaaa tcaacacctt tgtttatata cttcttagct aacaatcttg ctaaatacag
      781 atgtctttca ataagaatat ttctaatgtc tacattttta tttttattat ataaattaaa
      841 tagctctttt gtatccatat ttaggtaatg tgtagcatta gctacatttt tcattaaata
      901 tcaactccta aatatttagt catttttatt tttgtccctt gattatgttc tgattcaata
      961 tctacatcat ccattaaagt tttaattata aacaatccaa gaccactctc ttttggattc
     1021 tctaaatctg gtgtacttat tgagctaaca tcatatcctt ttccattatc ttgaatttct
     1081 atattaattg cattatctaa aatattaaat actatattaa atacatcatc tttactgtgt
     1141 tttattgcat ttgtacatgc ttcagatact gctaccttta tatcttctat atcatctatt
     1201 ggaaaaccca tcttattggc aattccagat gctgttaatc ttattatact aacataatct
     1261 ggatttgtag taatttccat ctttatagtc tcacaagcca aagtttatcc ctccacttta
     1321 aatattttat ctagacctgt tatagtaaaa atctttctta cgttactctt aggatttact
     1381 atgtatatct ctttttcatt tatttttaat ttttttaata cacctatcat agctcctaag
     1441 cctgttgagt ctatataatc taaatcttta agattaatct ttacatctaa catatttttt
     1501 tctattaaag catgtaaatg ttcctttagt ttatctgctg tagaaacatc aagttctcca
     1561 tcaagacaaa cattccaaaa tttattttgt gaatctaaat ttgaatcaat attcatagac
     1621 atgtaaaaac ctcctatttc cttttaataa ttttaaatat atttcctata ctcaatattt
     1681 tattaattac ataaactata tcatctattc cctttgatat tgatgatgca ttttcaacaa
     1741 tatcttgtat atgtctttca ttataatcta caatcttata tgccttttca acaaccttat
     1801 ttatgctgtt tagagtttta gctaaataaa ttgctactat aagagcagag cttcctacta
     1861 acactgctcc aatttgccac ccccatgcat tcattagtta acatctccct catcatcaaa
     1921 gcttttactt attactatat cttcttctga aatctttata tcttcttcat tattatcatc
     1981 atccactaaa tttattattc tctctttaac atcattaaat gtttcatgta gaacttcttt
     2041 tggattttct ttaacatcat taaacttctc ttttgtttct tttcttagtt cagaaccttt
     2101 tttaggtgca aaaaacatac caaatataaa ccctaaaata gctcctaata ataaaaatcc
     2161 acctttttta caacttcttt tattgcacat aacaattact cctttcaatt ttaaattttt
     2221 atctaactac attatacaaa aagaatagga tatttatcct attcttcttc aatatttatt
     2281 ttggcaatcg aaactacatt gacttcatca ttcgtcttca ttaatttaac accacttgta
     2341 actcttccaa acagtgatat ttcattgact cttattctaa taagaactcc atcagaattt
     2401 ataatcatta tctcatcatc ttcgttgacc atatctgcac ctacaattgt accagttttt
     2461 tcagatatat tataagtttt aattccttta ccagctctta tttgacttct atactcttct
     2521 atatttgttc tctttccaaa accattctta cttacaacta acacatctgt acctttactg
     2581 caaaggttca tagacacaac aaaatcttct ttacttaaag ttataccttt tacacccatt
     2641 gctgttctac ccatatatct tatatcattt tcatcaaatc ttatagacat accttcttta
     2701 gttactaaaa gtacttcttg ttttccatct gtaagttcta ctccaataag ctcatcatca
     2761 tctcttaaac ctatagcaat aagaccagat ttatttatat ttttgaactc ttctctctta
     2821 gtctttttaa caataccttt tttcgttgca agtaataaat attcattttc atcattacca
     2881 tcaataggta ttagagtagc aattttctca tctgctgaca attgaagtaa attcactata
     2941 gcagtacctt tagcctgtct cttaccttct ggtatttcat atgcatttaa tttaaatact
     3001 ctacctttat ttgtaaagaa taatagtcta ctatgagtag ttgtagttac caagtgcctt
     3061 acaaaatctt cttctctagt tgtaagtgct gaaatacctc ttccacccct tttttgactc
     3121 ttataagtat cagatggaag cctttttata tatccaaagt gagtaagagt tattgctatt
     3181 tcttcatcac ttataagatc tctcatatct atttcgcctt cagcatgtct tatttctgtt
     3241 cttctctcat cagagtaatt ttcttttatt attgtaattt catcctttat tacatttaaa
     3301 agtaatcttt catcagctaa aatctctttt aatctattta tcttcttgat taaatcttca
     3361 tattcagctt ctatcttatc tctttctaaa cctgtaagtc tttgaagtct catatctaat
     3421 atagcttgtg cttggatttc agttaatttg aatttttcta ttaaacctag cttagcttct
     3481 tgcccagtct ttgaagctct tatcaagctt ataacagcat ctatattatc taaagcaatc
     3541 tttaatcctt ctaaaatatg tgctcttgct tcagctttat ttagttcaaa tttagttctt
     3601 cttgtaacaa catcttcttg atgtttaata taatgatata atatttgttt aagatttaaa
     3661 actcttggct gaccatctac aagtgcaagc attattatac taaaagtatc ttccatttga
     3721 gaatgtttat acaaattatt taatactata ttagcattag catccctctt taattctata
     3781 acaattctca taccatttct attactttcg tctcttaggt ctgatatacc ttctattctc
     3841 ttttctttaa ctaactctgc tattctttca accagtttag ccttatttac ttgataaggt
     3901 atttctgtaa ctattatttg ctgttttcct tttggtagct cttctataaa agctctagac
     3961 ctaactttaa cttttcctct tccagttctg tatgcttctg ctatactttc ttttcccatt
     4021 ataattgcag ctgtagggaa atctggtcct tgaacaaatt ttattaaatc atctacacta
     4081 cactctggat tatctatcaa atatacagtt gcatcaatta cttctgctaa attatgtgga
     4141 ggtattgaag ttgccatacc aacagctata ccatttgagc catttactaa taaattagga
     4201 tatctagctg gcaatactga aggctctttt aacgactcat caaagtttgg tttaaagtct
     4261 acagtttcct tttcaatatc tctcagtagt tctaatgata atttactcat tttagcttct
     4321 gtataacgca tagcagctgg tgaatcccca tcaacagaac caaagttacc atgaccatct
     4381 actaaaagtg ctctagttga aaaatcttgt gccattctta ccatagcata ataaacagca
     4441 gtatctccat gaggatggta cttacctaaa acgtccccaa caatacgagc tgacttcctg
     4501 tatggtttat ctggagttaa atttaactca ctcattgaat ataatattct tctatgaact
     4561 ggctttaaac catctctaac atcaggaaga gcacgtccag ctataacact cattgaataa
     4621 tcaatatacg attttttcat ttcttccgct atttcaatag ggagtatttt gttattttct
     4681 tccatgtata ctaatcccct ctctctatat atctaagttt ctaacaaatc ttgcattttc
     4741 ttctataaat tcttttcttg gagcaacctt atcacccata agcattgaaa atacttcatc
     4801 tgcaattgca gcatcttcta cagtaacttg taataaagtt cttgtctcag gattcatagt
     4861 tgtttcccat aattgctctg cattcatctc tccaagacct ttgtaccttt gaagttcaac
     4921 accatttctt ccaatttcat ctaataagat atttaactct ttatctgagt aaacataatg
     4981 ttccttcttt tgctttgtca ctttatataa aggtggctgt gctgcataaa catacccctc
     5041 atctataaga ggtctcatat atctaaagaa gaatgttaat aataaagttc ttatatgggc
     5101 tccgtctaca tcagcatcgg tcataattat aattttatga tacctagcct tatctatatc
     5161 aaaatcttct ccaataccac aaccataagc tgttatcata ttttttattt catctgaaga
     5221 tagtatccta tctagtcttg atttctcaac attaagtatt ttccctctta atggaagtat
     5281 agcttgacta tttctatctc taccttgttt agctgaacct cccgctgaat ccccttcgac
     5341 taagaatatt tcacttttag atggatcttt ttctgcacaa tctgcaagtt ttccaggtaa
     5401 agatgtactt tctaatacac tttttctcct tgttaattct cttgcttttt ttgcagcttc
     5461 tctagctctt tgtgctctta aagctttatc aactatgatt cttgctgttg atgggttttc
     5521 ttctaggaaa gaccccagtt catcaactgt tacactatca actatacctc tcataaagct
     5581 attacctagc tttgttttag tttgaccttc aaattgaggt tctggtaatt taactgatac
     5641 tactgctgta agaccttctc ttatgtcttc accaagtagg ttaacatcat tttcctttaa
     5701 aaatttattt ctcttagcat aatcatttac agttttagta agagctgctt taaatccact
     5761 taaatgagaa ccaccttcat gtgtatttat attgtttgca aaagaatata tgttctctgt
     5821 ataaccatct gtatattgca tagctagttc aacaaaacaa tcatcaacct ttttatctat
     5881 ataaactatg tcatcatgta taccagttct agatttattt aaatacttaa tatattctac
     5941 caaaccacct gtatagtgaa attcttttct tttttcttgt ccttctcttt tatcttcaaa
     6001 tactattttt attcctttat tcaagaaaga aagttctcta agcctatact ccaatgtttc
     6061 atatttaaac tctatttcat caaatattgt ctcatctggc ataaattgaa tcattgttcc
     6121 tttatcttga gattctccaa ctacttcaag cttagatgtt ggcaatcctt tctcatatgt
     6181 ctgcttatat ctctttccgt ttaaataaac ctctgctacc atccattttg acaatgcatt
     6241 aactacagaa acaccaactc catgaagacc tccagatact ttatatcctc cgcctccaaa
     6301 ctttcctcct gcatgaagat tagttaatac tgtttctaaa gttgatttac cagttttagg
     6361 atgtatttca acaggtatac ctcttccgtt atcttttact aaaacactgc catcttcatt
     6421 aatagataca tatatgtctg aacaatatcc ttgtaaagcc tcatctatac tattatctac
     6481 aacttcataa actaagtgat gtaaacctct agggcttgta ctaccaatat acatacctgg
     6541 tctttttcta acggcttcta atccctctaa tacttgtatc tgacttgcac cgtattcttg
     6601 tttcatttaa tttcctccat tctctatgct aataacatcg ccattttcaa tattaaatat
     6661 tgtaacattt ttttcatcaa atattttttt atgtgaaact tcagcacttg ttataaacat
     6721 ttgaacattg cttaaattat ttactaaaag tttttgtctt gcttcatcta actcactaaa
     6781 aacatcatct aaaattaata ctggatattc ttcaacttca ttttttatta attctatctc
     6841 tgataacttt aatgatattg aagcagttct ttgttgacct tgtgaaccaa aaagtcttgc
     6901 atctaaatca tttatgaata tatttaagtc atctttgtgt ataccatatc tggtagtctt
     6961 agattctata tcattaggtc tattcgatga caacttggct aaaaatttat tatatactgt
     7021 atctatagta tcttcatcag ttatatttat ttgattttta tatcgaattg ataatctttc
     7081 aactccatta gtcaaattca tatgcatatt ttcagatata ttagctatct tttttataaa
     7141 gtctctacgc aaaatataaa tataacttcc atactttgct aacgtatcat catatacatc
     7201 taataaagct tcatcaacat gtatattttt aagcacccta ctcctttgag aaagtgtttt
     7261 attataattg gtaagatatt tataatattt aggtataatc tgactaatct ctttgtctat
     7321 aaatgccctt ctttctttag gaccctcttt aaccaacctt aaatcctcag gagaaaatat
     7381 aacaacattt aagttgccaa gtagttcttg tatcttttgt aaaggaactt tatttattct
     7441 tatccctttt ttatcttttc caataattag ctctattaga ctatatttat tatattttga
     7501 aaaacttcct ccaatatata agttttcact attaaatcta accatttctt tatctttgtt
     7561 agtcctaaat gattttccaa aagaaagcat ataaatagat tctactatat ttgtctttcc
     7621 ttgaccattt ttaccaacaa gtagatttac tttcccatta aattccagat gcaacttttt
     7681 ataatttcta aaattaacaa gttgcaaact tttaagtttc acaaaaagtt ctcctttttt
     7741 acaatacttt tattttagtt ccttctattt caactatatc tcctgatttt atcttttttc
     7801 ctcttcttaa ttctatttca tcatttactg tcactaaacc ttcttgaatt aaaaattttg
     7861 catgacctcc tgttgatgca atctctgcta atttaagaaa ttgatccaac tttatatatt
     7921 ctgattctat agttatttca gtcataatag ttcctccttg tcactatttt aaacaaattc
     7981 ctattgatac actaaaagta tattatacca taaatatgct tataaaagga gttgtctaag
     8041 attagaaaaa ttttctacaa aagacaactc cttcatgtct gctatatatt tgatgatatt
     8101 cttactggaa gcagtaagta aatataatta acatcatctg ttggtttaat tatacaagga
     8161 tttacatttg tagtaaattc tataaatatt tcctcattat ctatattttt caaaccttcg
     8221 ataaaatatc tagaattgaa agctatatct aggtaatctc catctaaatc tatttcaact
     8281 tcttcataca catttccttt ttctgtatta gaagtaattg ccattacttt atctcttata
     8341 gataacttta taagattatt tttttctgat tgagacaata aagacgctct ctctatacta
     8401 tttaaaagtt ccttagtatt taatttaact ctgctgttat gttctcttgg caataatttt
     8461 ttataatcaa taaaatctcc ttcaagcaat cttgtaataa ttttcgtatc attaattata
     8521 aaaatagcat ttttttcgtt aaatccaact ttaacattat cctctccaga aagcaaacta
     8581 tttacatcta taagtgtctt tccaggaatt atgactttta tattttcagt taaactatca
     8641 accgaacaac tttttacagc taatctatat ccatcaattg ctactaaatt taagtttcta
     8701 tctacaattt ctaaaagttc tcccattaaa acaggttttg tttggtcctg tgagatagca
     8761 aatacagttt gtttaatcat attttttagg atttcttgag gtatgctata taaatcttct
     8821 tcatttaatt ctggtaattt aggaaattct tttgctgcat aacctttaat tttaaatctt
     8881 gaatttacac aatttatgta aatattattt tctgaatcag tttctatctc aacaaaggaa
     8941 tctggtaatt ttctaattat atctccaaat agccttgcat ctacaacaac atcacctttt
     9001 tctatgattt ctgcttgtac ataagtttct attcctattt cagcatcata tccagtaagt
     9061 tttaattgac cttcttctgt agatataagt atacctttta ataattctat tgttgttttt
     9121 ccattaatag ctttttgagc aattccaatt ctatttgcta ggattttttg attacaaatt
     9181 attttcaatg tggataacct cctctggctt tttatatata aaaataagtt aaaatcatag
     9241 tagtaatagt agtaggtgtt gttgataatg ttaataagta tgtataacat tataaataca
     9301 aagatattaa catgtgtata agatgttaat atctttgtta ttttagactt gataatttgt
     9361 taataatttt tgttcaaaaa aagtattaac aggttattca agagatataa acatacaatt
     9421 gtgtataaat tatcccttca aatctgatat aattttgtct attttagtct taatttcttc
     9481 actttcttct atatccttag atactttgtc atgagcatga attactgttg tatggtctct
     9541 acccccaaac tcttcaccta ttttaggaag ggataaatca gtaagctcgc gcgttaaata
     9601 catagctatc tgtcttggat aagctattga acgtgttctt tttttagaat taaaatcttc
     9661 catctttaaa ttgaatacag aagatacttt ttcttttatt ctgagaacat ttatttcttc
     9721 atttttagaa gttgttataa tatcttttaa agcttctgta gcaagatcaa aagatattac
     9781 cctattgcta agagaagaat aagcaaccac tctagttaat gcaccttcta gttcccttat
     9841 gtttgactta atattttttg ctatatatga cataacctca tttggcacat ctatacgttc
     9901 tagttgagcc ttttttctaa gtatagcaat tcttgtctca aagtcaggtg cttgaatatc
     9961 agttataagt cccatttcaa atctcgatct tagcctatct tctagtgtag gtatgtcttt
    10021 tggcggtcta tcactagata taattatttg tttgtttgct tcatgaagag tattgaatgt
    10081 atggaaaaac tcttcttgag ttctttcttt tcctgctata aattgaatat cgtcgattag
    10141 taatacatct acgtttctat atttattcct aaattcttcg tttttatcgt cttttataga
    10201 gtttataagt tcattagtaa atttttctga agaaacgtaa actacttttg agtctttttt
    10261 ttgactaaca atatgatgac ctatagcatg cattaggtga gtcttaccta atccaactcc
    10321 tccatacaaa aaaagtgggt tataagcttt agctggagat tctgcaactg caacgcatgc
    10381 agcatgtgca aatctattac tattaccaat aacgaatgta tcaaatgtgt attttggatt
    10441 tagattgggg taaagaactc tataatttaa atctgtgcta tcagaattta aatcagcaac
    10501 ctctttttcg ctcaatacaa atttaatatt atattttttt aatgacagtt gactaatagc
    10561 atcttcaatt aaatgtaaat atctattctc taagatatct ttattaaaat cactaggagc
    10621 cagtaagatt aaatcattaa gatgtatttt taatggtacg atgtttttaa aaaaggtatt
    10681 aaaacttact gaagttaagt caccttttat taattgtagg gttttgtccc ataaagaaac
    10741 tatatccata atataaacct ccgaacagaa taattaatat tttccacaaa gttattaaca
    10801 gaaaagcaaa aatatatata aattttacag aataactaaa tttatggata atggtgttga
    10861 taaattaata atagtataaa ttattaaaaa aatatgaaaa gatataaaca atatgtagat
    10921 aaagttataa ataacataaa catacaataa atggtgatta taactagagt attgtcagta
    10981 atcttaaaag ttatacacaa aagtatccac aagctgtgaa taatttctaa taagttgata
    11041 acatttatgc acattatcaa caagtatatt tataatatca aaatatatgt caaacttcaa
    11101 tgatttgtaa ctaatttatc cacaatatta actaattgtt gataaaaata taaacatgtt
    11161 aaaattactt tatttgtgta tataattgaa aaaaataatt tagaataaaa ttaaatagat
    11221 ttttactagt attttcaata aaaaaaatac ataatatata tatggtagat tttgtgatat
    11281 aagcgtccca aaaactcgtt gacaacagta gtaaaagtat ttataattat atgtgttatg
    11341 tttactttga gggtaaagtt attattttta taaacggaaa ataaaatctg aaaggcggtg
    11401 caaaataatg agtaaaagaa cttatcaacc aaaaaagaga caaagaagta aagaacatgg
    11461 tttcagaaaa agaatgaaga cgtctaacgg aagaaacgtg ttaaagagaa gaagagctaa
    11521 aggaagaaat agattaactc attaattaca aaagggccgc tgcaaaggtg gcctttttgt
    11581 gtaaataatt acaattcata gctgtgttta tggaggttaa ctatggactt taataggact
    11641 aaagggttga aaaaagactc tgattttaga aaagtatata aacacggcaa atcttttgca
    11701 aacaaatatt tagtaatata tatacttaaa aataaatcag attatagtag agtaggtatt
    11761 tctgtttcaa aaaaagtagg aaaagctatt actaggaata gagtaagaag attaataaaa
    11821 gaagcctaca gattaaatat tgatgaaaaa attaagcctg gatatgatat agtatttata
    11881 gcaagggtat ctagtaagga tgctactttt aaagacatag acaagtctat aaaaaattta
    11941 gttaaaagaa cggatatttc tatttaattg tatgctataa atatggaggt taatgacttt
    12001 gaataaaata atttatatat taaaggaaat aagtaagcat ttatcgaatt tatgtattta
    12061 tttagtgaga ttttatcaaa agtatatatc tcccttaaag ggacctacct gtagatttta
    12121 tccaacttgc tcacaatatt caatagaggc gtttaagaaa tatggatttg taaaaggtat
    12181 gtatttaacg ataagaagac ttttaaaatg tcatcctttt catccaggag gttacgaccc
    12241 tctaaaataa aagagagtaa ctattaggag gtataaaaaa attgaatata ataggaaatt
    12301 tcttaggatt gattcttaag gtaatatttg aatttgttaa tcattatggt atttctataa
    12361 tactttttac gatacttgta aagattattt tattaccatt aacaattaag cagactaagt
    12421 caacaaaggc aatgcaagat atacaacctc gtataaaaga gatacaagaa aaatataaaa
    12481 ataagccaga aaaacaaaat gaagaaattg ttaagttata tggagaagct aaaattaatc
    12541 cactatctgg ttgtttacct ttattaatac agtttcctat attaatagga ttatttagcg
    12601 ttttgagaga accagttgct catggcgttt ttgcaaacaa agctgcattt ttagcagctg
    12661 acaatgggtt tttatggata aaaagcttaa catcaccaga ttatgtatta gcagtatttt
    12721 caggagcaag tgcatatgtc atgcaaaaag taatgacacc aaaagatcag ttacaaggct
    12781 ctatgaaagt aatgacatat gtaatggcag gtatgtcttt ctattgggga tttatattcc
    12841 cagcaggact tacattgtac tggacagtaa gtaacttatt ctcaatagct caatattact
    12901 taataatgaa tcctttaaaa gctaaactgg ctgctaactc taaggaggaa aaagttaatg
    12961 agaaaaagcc taaaattaat aaaaagtaag agtaaagagg aagctataag taaagctata
    13021 gcagagttga atttaaaagc agaggatata gaagtagaaa tacttgaaaa tccaagtaaa
    13081 gggtttttag gttttatagg tgctaaagat ggtacttatg aaatttttgt tatcgagagg
    13141 gaagtagatg tagctaaaaa ttttatagag gtaatgttga aaaatgcaaa tgttgatgcc
    13201 aaagtcaatg tatctcaaaa agataattta atcatggttg atattgaagg caaagaagct
    13261 gcaagtttaa ttggtagaag aggggaaact ttagattcta ttcaattttt gactggatta
    13321 gctcttaata aaataaataa agattctcat acaagagtac ttgtagatat agaaaattat
    13381 agatcaaaac gagaagaatc tttaataaga tatgctaata aagttgctag agaagtagcg
    13441 aaaacaagaa aaactaaaaa attagattat atgaatccat atgagagaag aataatacat
    13501 tcagctcttc aaaatgacaa atatgtaatt acatatagtg aaggaaccga tccatataga
    13561 agattagtaa ttgagtgtaa aagataaagt caacctccta aacattaggg ggttttattt
    13621 tttaatatta ttaaatcatt aatggttggt taaatgtaaa tctatatgta aaaaattatg
    13681 aattaagagg tgataaattt gtttatagat gatacaattg cagcaatagc tacagcacct
    13741 ggagaaggtg gtataggtat acttagaata agtggagaaa aagctttgaa ggttgcagaa
    13801 gaaatcttta aatctatgtc tggaaagagt attgaagaat acaataagag aacattaata
    13861 tatggaaata tagtggataa tgaaaatgta attgatgaag ttttattggc atatatgaaa
    13921 ggaccaaatt cctatacagg agaagatgtt atagaaatta attgccatgg tggatttatt
    13981 tcggtaaaga agatattaga attaatacta tcaaaagatg ttagattagc agaggctggt
    14041 gagtttacta aaagagcatt cttaaatgga agaatagatt tatctcaagc agaggctgta
    14101 attgatgtta taaaagccaa aactgatata gctcatgaag ttgctcaaaa tcaattagag
    14161 ggttctttat caaagaagat aagagaattg agagataaag tcactgagat attagctcat
    14221 gtagaagttg ctatagatta tcctgaggaa gatattgagc atataacata tcaaactctt
    14281 aaagaaaaaa ctgatgaact taaaaaagac attaaaaaat tatatgatac agctgaaagt
    14341 ggaaaaatac ttagagaagg cttaaagacg gtaattgttg ggaaaccaaa tgtaggtaaa
    14401 tcttcactac ttaattctat tttaggagag aatagagcaa tagttactga tataccagga
    14461 actactagag atgttataga agagtttgta aacataaaag gtataccttt aaaaattgtt
    14521 gacacagcag gtataagaga tactgatgat attgttgaaa aaataggtgt tgaaaagtct
    14581 aaagaatcat ttactagtgc agatttgata gtaatggttt tagatgcatc tagaaagttg
    14641 tcagaagaag atatagagat attagaaaaa cttaaggata aacaaacaat agtgctgtta
    14701 aataagaatg atttgaaaca agagattgaa gaagaaaaaa tacttaaata tgtagaaaat
    14761 aatagtataa taaaaatatc agctttacaa caagaaggaa tagaagaatt gcaagataaa
    14821 atagagtcta tggtatataa aggtagtatc aaaaataatt ctagtttagt agtaacaaat
    14881 tcaagacata aagatgcact tagtaaagca tataaatctg caacagatgc tttaattgct
    14941 ttggaacaaa gtatgccatt tgactttgta gaagtcgatt taaaaaatat atgggactat
    15001 cttggatata ttaatggtga tacagtaaca gaggatttac tagataatat attccataat
    15061 ttctgtattg gtaagtaatg tacaaaagta aacttgtttt tattatagag atttttaaaa
    15121 aatttgaagt gtttctcatg aaacattaat tttgaaaaga aaggaattat aaatgataaa
    15181 gtttgaagca ggaaaatatg atgttatagt agtcggagca ggacatgctg gatgtgaagc
    15241 tgctttggct actgcaagaa tgggatataa aactttgata ataacaatgt ctttggattc
    15301 catagcatta atgccttgta atccatcaat tggagggact ggtaaaggtc aattagttaa
    15361 agaaatagat gccttaggcg gtcagatggg attaaatata gacaagacat atatacaaag
    15421 tagaatgtta aatactgcca aaggtccagc ggtacactct ttaagagcac aagcagataa
    15481 atttaaatat catgaagaaa tgaaaaagac attagaagat gaaccaaatc ttgatatagc
    15541 tatggatgaa gttgtagaaa tacttcatga aggaaatgtt gtaataggag ttggaactaa
    15601 actaggatgt tcatttaaat ctaaagctgt aatattggcc actggagttt atctgaactc
    15661 aaagatatat atgggtgaag ttgcatttta tgaaggtcct aatgcattag ggtatgcaaa
    15721 atatcttaca gatagcttag ttgagcttgg ccttagaatg agaagattta agacgggaac
    15781 tccagcaaga gttcatagag atagtataga cttctctgta atgtctttac aagagggtga
    15841 tgaaaaagta actccattct catttatgaa tgaaaatata gaaaaaaaac aagaaccttg
    15901 ttatttaaca agaactacag aagaaactca aaaagttata ctggataatt taaaaaggtc
    15961 tgctatgtat agtggagtaa tagaaagtac tggtccaaga tactgtcctt ctatagaaga
    16021 taaagtagta agatttagtg ataaaacatc acatcaatta tttatagaac cagaagggtt
    16081 aaatactaaa gaaatgtata tacaaggaat ttcaactagt ttaccttttg aagttcaatt
    16141 agatatgtac aaaactataa aaggacttga aaattgtaag ataatgagac ctgcatatgc
    16201 tattgaatat gattgtgttg acccaactca actaaaaata agtttggaaa taaagggtgt
    16261 tgagaactta tttagtgcag ggcaatttaa tggaacttct ggatacgagg aagcagcagc
    16321 tcaagggctt atggctggta taaatgcagt tagaaagata gaaggaaaag agccatttgt
    16381 attagaccgt tcagaagctt atataggtgt cttattagat gaccttgtta ctaaaggaac
    16441 taacgagcct tacagaatga tgacatcaag agcagaatat cgactatatt taagacaaga
    16501 taatgcagat atgagattaa ctcaaaaagg ttatgatata ggattagtta aaaaagatag
    16561 atatgaaagg ttcctaaata aaaaggctgc tgtagagaaa gaatttgaaa gactaaaaaa
    16621 tgaaagagtt acaccaaaag aagtaaatag tttgttggaa gaaaaaggag caacaccaat
    16681 aaaggttgga atatctctat atgaattttt aaagagacca gaggttactt acgaattgct
    16741 tgaagaatta gggaaaggcg ctggagaaga tgtttcaaga gaagttaaag aacagtgtgt
    16801 aataataact aaatatgaag gttatataga gaaacaattg aaacaaatag accaatttaa
    16861 aaaacttgag aataaaaagt tggatgagaa aataaattat tcatctatag aaggtcttag
    16921 attagaagct agacagaaat tagatgatat aaaacctatt tcaatagggc aagcatctcg
    16981 tatatctggt gtttctccag ctgatatatc agttttactt atatacctag aacaaatcag
    17041 aagaactaga ggtggcaaag gtgaataata tagaacttct gaaaaacggg attgaaggtt
    17101 ttaatataga tacgaatgac agtatgttag aaaaatttaa aatctataga gagatattag
    17161 ttgaatggaa taaaaagatg aatcttactg gaatagaaga tgaaaaagaa gtgtatataa
    17221 aacatttttt agactctatt tcagctgtaa aaaatggata tataaaaaat gggatgtcta
    17281 taatagatgt tggtacaggt gctggttttc ctggaatacc attgaaaata tgtttagata
    17341 gcttagaact tactttgtta gattcgttaa ataaaagaat aaacttttta gaggaagtta
    17401 gtagagtact agagttagat aatattacat ttatacatgg aagagctgaa gattttggta
    17461 aaaatgaaga ctatagggaa aaatatgatg ttgctacggc aagagctgtt gctggattac
    17521 cgattcttat ggaattttgt gtaccatttg taaaagttgg agggtatttt atttgcttaa
    17581 aaggtccgaa tgctaattta gagctagaag aatcacaaaa ggctattgat gttttaggat
    17641 tggagtatat tgaaaaaata gatgtagagt taccagaggt agatttaaat cataatatat
    17701 tagtttttaa aaaagtgatg gaaacaccag ttaagtaccc tagaaaagct ggtaaaccag
    17761 ccaaaaatcc tattaagtaa tgaaaaattt attattggta agcttaatta tttctcagga
    17821 aataattaag cttactgtaa aaaaacaaaa ataaaggaat tattaaagta gatgcagaaa
    17881 taaatttgta tgtacatata gagaacaaaa ataatttata tctaaaataa gagaggtatg
    17941 ttatggaaga taaaagagtt atggagatac ctatagaaga tgtagttcca aatccatatc
    18001 aaccaagaaa aatattttca caagtttcat tggaggaatt gagcaattct ataaaggtat
    18061 atggtataat tcaacctata acagttagag caaaagatgg caaatatgaa ctaattgcag
    18121 gagaaagaag attaagagca gctaaattag cagagcttaa aaccatacca gcaattataa
    18181 ataatatgaa cgatgaatct tctgctgttc tagcgttatt agaaaatttg caacgagaag
    18241 acttaaattt cattgaagaa gcaattggtt atgaaaactt aataaaagaa catgctttta
    18301 ctcaacagca attagcagaa aaattgggca aaaatcaatc tactgtagca aataagctta
    18361 gaatattaaa gcttccaaac gatataaaaa tgaagctaat agagaataat ttaacagaaa
    18421 gacatgctag agcatttctt aaactaccaa gtgaagattt aatgcaaagt gtgttagaca
    18481 aagtcataaa aaatgaattg actgttaaaa aaacagaaaa attgatacaa gatgtattag
    18541 aagaaactaa agttcaagaa gagcctgata aaaaacagaa tataaagggt gctatgagta
    18601 taagaattta cataaatact ataaagcagg cctttgatgc tatatcaaat acaggaattg
    18661 atgctaagta taatgaaata gataagggag attatatgga agttgttgta aaaatcccta
    18721 aaaaatagag attactgctt accagtaatc tttttttgta atataagcct tgtaatataa
    18781 attgatttat agacattatt tatacttaaa aaacacctat tcaacattta aaattaattt
    18841 aattcttaaa ggggggaaca tcatgggcaa agttatagct gtattcaatc aaaagggtgg
    18901 agtcgggaaa actacaacaa atgtaaattt aagtgctagc ttaggaactt tgggaaagaa
    18961 aatattagta ttagatttag acccacaagg aaatacaact agtggatatg gtattaataa
    19021 aaacgaagta gaaaatacaa tctatgaaat tatgttagat gggttacata ttaaagaagc
    19081 aataataagt actgaatttg agaatgtaga tgtagttcca tcagctactg aactatcagg
    19141 tgcagagata gagcttacat ctaaaactaa tagagagtat attttaaaaa attccataaa
    19201 agcggtaata gatgaatatg attatatatt tttagattgt ccaccctcac tggggatgct
    19261 tacaataaat tgtttaactg ctgtagatag tgttttaatt ccaatacaat gtgaatatta
    19321 tgctttagaa ggtgttagtc aattaatgga gactataaaa ttagtaaaat caagattaaa
    19381 tgctgatata gaaattcaag gtgttgtttt aagtatgttt gatggaagag ctaatttatc
    19441 aatacaagta gttgaagaag ttaagaaata ctttaaaggt agtgtatata caactttaat
    19501 tccaagaaat gtaagacttg cagaagctcc aagtcatgga aaacctgtaa tttattatga
    19561 taaaagatgt agagggtctg tagcttattt ggaactagca gaagaattta tagatttaga
    19621 agaggaggaa tggtagtatg gagaataagt ctaaaagaag taatagatta ggtagaggtc
    19681 ttagtgcatt gataccagaa attaaaggag aaacttcaga aaaagaaata gtcaacatag
    19741 atatagacaa aatatatcca aacgaagttc aacctagaaa gcaatttgat gaagaaaaga
    19801 taaaagtatt gtcggattct ataaaaaatt atggtgtttt acagccaata gtggttaaaa
    19861 tggatgaaaa taataaatat atgataatag ctggagaaag aagatttaga gcatcaaaac
    19921 ttgcaaataa aaatcaaata cctgctataa ttaaagatat agatatgaaa gatataatgg
    19981 agatagcctt aattgaaaac ttacagaggg aagatttaaa ttcaatagaa gaggctctag
    20041 catataagag tttaatagag cattacaatg taactcagga agaaatatca gaagctgttg
    20101 ggaagagtag acctcatata actaatacac taagactttt aaatcttgga caagatgtta
    20161 tagaaatgat agacagtggt agaattacag caggccatgg taaggcttta ttgagaattg
    20221 cagataaaga tttgcaactt caaatagcga aaaaaataga agaagaagaa ctttctgtaa
    20281 gagaagtcga aaatatagct aaaaaaatat ctgaaaataa acaagaagaa cctaaaaaat
    20341 ctaaacctaa ggatgtattt attttagatg ttgaagataa acttagaaat atatttggaa
    20401 caaaggtgaa tatttctaaa ggaaagaaaa aaggtaaaat agagatagaa tactataatg
    20461 atgatgattt aaatagtatt gtatcaatgc ttcttgaata gaacaaaaat ataaaacaga
    20521 gaggaagatt gttatgattt atttagataa tgctgcaact acatatccaa aaccagaaag
    20581 agtgtataat gctgttttag attgtatgaa aaattattgt gcaaatccag gtagagcagg
    20641 ccataaactt gctatgagag ctgctaggga gatatatgat acaagagaga atatagctaa
    20701 gttgttcaat gtaagtaatc ctatgaatat agtatttaca tctaatgcaa cagattcttt
    20761 aaatttagcg ataaaaggtg tattacaaga aggagaccat gtaataacaa cgtctatgga
    20821 gcataattca gtaataagac ctataaaagc attggaaaaa aggggtattg aaaatactgt
    20881 agtaaaatgc gattatgagg gatttttaga ttatgaagat ttagaaaaat caataaagaa
    20941 taatactaaa ttgattgtaa caacacatgc gtctaatgta tgtggaactt taatagatat
    21001 aaaaaaagtt ggagaaatag ctaaaaaaca taatatacta tttttagtag atgcatcaca
    21061 aacagcaggt gtttatgata tagacgtaaa tgaatgtaat atagatatgt tggcaatgcc
    21121 aggtcataaa tgcttatttg gacctcaagg aacaggtata ttatatgtaa gagaagggtt
    21181 gaacttaaat atattaaaag aaggtggaac aggtagtaaa tcagaagaaa tagttcaacc
    21241 agagttattc ccagataaat atgaatcagg aactcataat actccaggta tagcaggtct
    21301 taaccaaggt atactattta tatttgaaag aggaatcaac aatataagac aacatgaaga
    21361 agaattatgt caatatatga tagacaaatt agaggaagta ccagatataa agatatatgg
    21421 accaaaggac agtaaaaaaa gagcatcagt aatagctcta aatataggag atatggattc
    21481 tggagaggtt actttcttat tagatagtga ttataatata gcgactagat caggaataca
    21541 ttgttcacca ctagcacata ccactttagg tactttaaaa caaggtgcag taaggttcag
    21601 tataggatat ttcaacacaa aagatgagat agataaagca gtggaagctt tgaaaaaaat
    21661 ttcaaaaaat aaatagcatg agatttaata atatagaaat aaaaaaaggg gatatttcaa
    21721 aataaaaatt tgaatcatct ccttttttgt acaaaaaaga aaaggggttc ctaagaacct
    21781 ctaatctatt tgataatagt ttcaagaaat tactttaagt aatctccttc ttcaagaact
    21841 atatgaccac tttcgtaatt agaaccatca acagtaattt ttatttgttc aacattcata
    21901 ttttttatgt aagtacgagc aactgaatca agcattaaag tttctgcatc actacctaag
    21961 tttgactttg taaagtcaga gctaacatct aatataccag tttttacacc atcaatgtct
    22021 tttgtagtaa atgaatttaa ttttgcagat tctggaacaa ctttaagttt ttgaagttct
    22081 tcaaataaag tgttctcatc aattttattt aaatcaactt tattttcaat taaatctgtc
    22141 ttatctacat caaaagagta aatagtagct gattgagctt tagtttcttc ttttggagta
    22201 ggtttagctt tgttattagg aacctctttt tcagtattgt tttcttcttt tggttgctca
    22261 acatttgtat tgctcttagt ttctttttta gatgaatcac ttccattttg agcattagta
    22321 caaccaactg cgaatataga tatagataat atacttaaca ctaacattat tttcttattt
    22381 ttcataaaaa tttctcctct cttaaaaact attcttatat ataattatag tcgttatgag
    22441 caaatatatg aatacaaaat agtaacaaat ttaaaaaatg atttatttaa attaataaaa
    22501 ctcaaaataa actaaatttt agtcattttt atgggaaatc atttaatgta cagtgaaaat
    22561 attgtaaaat aaaagtagtg tttttaaaat aaatataagt tataattata ttataaaaaa
    22621 atgtcttcaa aaggtgggaa tagtatggaa attttgagct taggagaaaa gattaaaaag
    22681 ttaagaaaag aaaaaaacat gacattgaaa gaattagctg gagataggat aacagcagca
    22741 caaataagcc atatagagag agataaatct catactagtt atgaactgtt ggaatatcta
    22801 ggcgataagc tagatgtaag tgtagaatac ttattagaga ccaaggaaat gcaatcaaaa
    22861 aagataactg ataatttaat actacagagc gaaatttata taaaagaaaa tgaattaaac
    22921 aaggctgagg accaaataaa agaagtttta gatatatgta agagatacga tttaatggag
    22981 aactatggca gatgtaattt tttaatggct aatattaatt tgaaaaaatc taattataat
    23041 gatgctatag aaaactttga aaaggcattg tacttcttta taaaaaatag tgatagtgaa
    23101 aatatactta agtgttattt aaacataggg aaaatatata tgcaggaaga cttttataaa
    23161 ggtgctataa gccactttaa ttttgcagag gaaattttgt cagagagtaa atttgaggat
    23221 gttaacatac acaaggaact atatagtaag atggcatatt gttacataaa actagataat
    23281 ccaaatatgt cattgaagta catagaaaag ataaatgaaa tagataatag aaatgataga
    23341 aaagaagatg tcgatatttt ggtgttaaaa gcaaataata tgcttgagat tggaaaatat
    23401 gaagaatcaa gagattactt taaaaaagca ctaaaaatac ttgagagtga ggataataaa
    23461 actggattag caaatgtgta tttaacaatt tgtgatgttt acagaaaaat aggtgaaaca
    23521 gatagagtac ttgaatattc acaaaaggta tatgacataa agaaaaatga tgaagatgaa
    23581 tacatgatgt caggattatt taagataata gaagcatata tagataaaga agattatgat
    23641 ttagctagaa aatattgtaa gatagcctta gcttcatcaa taaaaaataa aaataaattc
    23701 aatgaatata aagcattgag attctatgct aatatgtata aaaatcagaa tgaagtaact
    23761 cttgcaattg aatatctgat taaatgcata aaaatagtat cagatttagg caacaataga
    23821 atattggcca atttatatat agacttaggt caattatatt caaatatatc aaaagaaaaa
    23881 gagttagaat attatcaaaa aggtgtattt atgtacaaaa atttagaaat aatgtagggt
    23941 aaataaacct ataagggtat agaaacaatc tataacaagc aagataatat ctatgataaa
    24001 atataaattg tatgaatatt tttaaggaga tgaatcagac aatgagtata aaaatagatg
    24061 cgagagggct tgcttgtcct aaaccagtta taaatacaaa aagagaattg gataacctag
    24121 aagaaggtgt tgtagttaca atagttgata atgaaacagc taaggagaat atattaaaac
    24181 ttgctaaatc tttaagttgt gaagcaaata ttgttgacga aaaagagaat tttatatcta
    24241 tagaaattag aaaaggtaaa aatatactag ataaacaaaa tgttgtagat aataaagaaa
    24301 gtgaattaga caatacatgt atatttatat cttcagataa gatgggactt ggaaatgacg
    24361 aattaggaaa agtgttaata aaaggattta tatatacatt aacagaatct aaaccttatc
    24421 ctaagtatgt acttttagtt aatggaggag taaaattaag tgctgaaaat gaagaaacca
    24481 tagaaaatct aaaaatactt gagaatatgg gtgtagaagt tttatcttgt ggtacttgtt
    24541 tagattatta taatttaaaa gacaaattac aagtaggtac agttacaaat atgtatacta
    24601 tagttgagac attaaagaat gcatcaaata ccatttctat ataatgtatg tatgtttaat
    24661 aatataaaac taacaataaa gattaactca aatagatagt cagaaaggat taagtaatga
    24721 atcaaatgta tatagtgtca tttaattcga cacatcatgc gataagatca gaaaagttat
    24781 ttggtgaaaa tagtctaaaa gtaatggctc ttccaacacc aagagaaata acagcaagtt
    24841 gtggaatatc aattaaattt tcttttgaag atatggaaaa gataaaaact attttggttg
    24901 aaaataatgt agatataaaa ggaatttatt gtataagtaa attagaaaat ggttcaaaag
    24961 aagtagagaa gttagattag gaggctaatt atttatgcca atggatttaa aaataggtga
    25021 tattgttgaa ttaaaaaagc aacatgcatg tgggtgtaaa gagtttgaaa tcataagaac
    25081 gggaatggat ataaagataa aatgtactaa atgttcaagg ctaataatgc ttgatagaga
    25141 gaccttagaa aagagagtaa aaaagctaat aaaaaagtga taaaaattta acacttaaaa
    25201 aatgtcaaat accgtatatt aatatccaaa attttggtat aataagaatt gaagaaaaca
    25261 ttttcatggg ggtgctttaa ttatggcagt taaatatgca aaaagaatgc aaggattaca
    25321 aggatcagaa atacgtgagc ttttaaaact tactcaacaa ccacaaataa tatcttttgc
    25381 tggtggaatg ccggctccag agttatttcc agttgaggaa atgaaaaaag tatcagttgc
    25441 agtgcttgaa gaaaatggaa gatcagctat gcaatatact acaacagaag gatatgaacc
    25501 attaagagaa aaaatagcag ctagaatgaa tgataaaaac aaaactaatg taaacaaaga
    25561 tgatatatta gttacaagtg gttctcaaca aggtctagat tttgcaggaa aagtatttat
    25621 tgatgagggt gatgtaattt tatgtgaaag tccatcttac ataggagcta taaacgcatt
    25681 taaatcttat caacctaaat tcatagatgt tccaacagat tctgatggaa tgataatgga
    25741 agaattagaa aagatactag aaacaactga tagaataaaa atgatttatg taatacctga
    25801 cttccaaaat ccaacaggaa gaacttggcc acttgaaaga cgtaaaaaat tcatggaaat
    25861 agtaaataaa tttgaaatac cagtaataga agataatcca tatggagatt taagatttga
    25921 aggagagact ttaccatctt taaaatcaat ggatacaaaa ggattagtaa tattcttagg
    25981 aactttctct aaaatattct gcccaggata cagattagga tggacttgtg cttctccaga
    26041 aattttatct aagtttaact ttgcaaaaca aggtgcagac ttacaagcat caactatatc
    26101 tcaaatggaa gtaagcaaat ttatggatat gtatgaccta gatgcacatg ttgacaaaat
    26161 aaaagcagtt tatgttaaac gtagagatgt aatgcttaag actatggaag aagagttccc
    26221 agaaggatta gtatttactc atccagaagg tggattattt acatgggtag agcttccaag
    26281 taatttaaat gctaaagaat taatgccaaa atgtttagat aagaatgttg cttatgttgc
    26341 tggaggagga ttcttcccta atggtggtag agaaaatact ttcagactta actattcaaa
    26401 tatgccagaa gaaaaaataa tagaaggtat aaaaaatata gcagctgtat taaaagaagc
    26461 tatgggtgta gaagcttaat taaaaataat aacttatata taatacaagg gatggttgtt
    26521 gccatccctt gtttgtttga aaagtatata attcacctta tactaaactt tgtccaaaat
    26581 ttaaattgac agaaataaga ataaatgata aaatgtgtag gtatgagatt ttagtctcat
    26641 ttctctgctc taagagtgta gagccgttaa gtccaaaggg aggtgaatta tagtgagaaa
    26701 ttatgaatta gtttatgtgg taaagccaaa ctctgatgaa gaagtaagag aggctatact
    26761 aaacaaagtt aaggaagttg ttgcaactga cggagaaata gttaaagttg atacttgggg
    26821 aactaaaaaa ttagcttatc caatagctaa gtttacagaa ggtttctatg tattagttaa
    26881 cttcaaatca gcagtagacg ttcctaaaga gatagacaga aacttaaaga taaatgaaaa
    26941 cgtaataaga cacatgatag ttgttgctta ataactggtt ttattataaa aaataggtgg
    27001 tgtttttatg aatcaagttg tattagtggg aaggttgact agagaccctg aattaagata
    27061 catcccaggt acaggaacac cagtggcatc ctttacaata gccattgata gagactatgt
    27121 aaaaaaagat ggatctaaag aaactgattt tatacctgtt gaagtaatgg gtaaatctgc
    27181 tgaattttgt gctaactaca taactaaagg tagattagta gcacttcaag gatctataag
    27241 agtagacaat tatcagacac aatcaggtga aaagagaact tttacaaaag taagtactag
    27301 atcagtacaa gctttggata gtaagaataa atcggaaaat tcatatagag agagtgctcc
    27361 agcttttgag ccaagctttg aacctcaagg tttagaccca caaggtttcc aagctataga
    27421 tgatgacgat ataccatttt aaaaaggagg gaaaaaagtc atgatgaata aaaaaagacg
    27481 taagaaaaaa agagtttgtc aattttgtgc tgacaaaaac gctaaaatag attacaaaag
    27541 tactcaaaga ttacaaaagt atataactga aagaggaaag atattaccaa gaagaatatc
    27601 tggaacttgt gctaagcatc aaagagaatt aacagttgct ataaaaagag cgagaaatat
    27661 agcactttta ccatatacat tagactaaaa aaatgagcct tgtgctcatt ttttattata
    27721 tgtatttata tatctaaatg aggcgagcta taaagctcgt ttttttgttt atatacttaa
    27781 atatattatt atttatgata taatattata tattaaggag ggttgtaaac gtgaaaatag
    27841 ataaaggttc tgagataacg agaaacataa agataataga atggatgaaa acagaaatat
    27901 taatgagtgt aagtgatttg tttaatttat tgtttaaagg ggtaaaacca ttagatgaag
    27961 caattcaaga tactttagca aatataataa tgataacata tctcttagca aagagattag
    28021 gaattagttt tagagatgtg gattataaag tcaaggaaaa aataaaaatt ggtatagatg
    28081 aggaccatag cgttgaaaga tggtatggag atttatctaa tttaaaaaaa catatggata
    28141 atagggagtg atattaaatt gaataataaa attagactat ctaaggcaat gtctataata
    28201 gttttagcta taataatcgc tttagtaata gcctatattc caatgctagg aatatttagt
    28261 atgttagcag ctgttccata tgtaattata ggtgctatta ctgatagaaa gtattctctt
    28321 atatctattt tggttacatt ttgtgtactg attctatttg cagacatttc ttatgcatta
    28381 aatatatgta taatgtattc tttaccaggt atagtaatag gaaagatgct aaagagaagc
    28441 tttgaacaag aggacagtaa taaattcgaa ccgatatatg gtggaaccat aatatttgta
    28501 ctttcaatgc ttgtatattt ttttgtatta aagacatttt taaatgtgaa tctattagat
    28561 gaagtttcta agatgatatc agaaattgta aatattcaaa aaaatagttt ttctgcaact
    28621 gaacttaaag tgtttgataa aatgaagcca gatgagattg taagttattt tacaaatatg
    28681 ctaccaatga tgttattttt acaagggttg ttatcagcgt ttgtcacata ttatttgagt
    28741 gtatttttta taaaaaggat tacaaagatg aatataagat ttcctaagtt tgctgatttt
    28801 tatttaccgg gaaatgctat actcacaact ttcttacttt atttattagt cttatttatt
    28861 caaattattg gttcaaaatt atatacagaa ttaataatga ctaatttaca gctagttttt
    28921 aatttaatgt ttgtaattca aggtatagca gtttgcattt atttcttaaa gaaatggata
    28981 agacagggac caaataaaat tatgtttttt tcagggataa ttttatgttt atttggattt
    29041 atgggaatat cttttgttgg tatggtagat agtataattg actttagaaa ggtaagaagc
    29101 tataaatcca cttaggagga tagaaatgag taataaacaa acctttaaat taaatatgcc
    29161 agaaataaat ttatatataa ttgttattgg tatttctagt ataattttgc tttattacaa
    29221 cttgtatgta gggtgtttat ttttctgtat ttttgtatat atggtttttc acaattggag
    29281 aactactaat attagacgtc atgaatggac agagtatatt caaaatttat ctttagatat
    29341 agatgaaaca actaaaaaag ccataataaa tcttccaata ccattatgta ttttagaatt
    29401 tgatggaaat atatcctggt ataatggaaa gttttatgat atgattggtc aaaaagattt
    29461 acttgataaa aatatagagg atatagttaa aaatcttaat ttaagaaaag tattaaatga
    29521 aaataaagag atgtacacag aaataaacta taaagaaaaa gaatatacaa taatttataa
    29581 tgttataaaa aatgatcaag aaaaaaatcc taaatatttg atgatattat actggataga
    29641 caagactgaa tatttaaaag taaaacaaaa ttatgatgat gaaaaaaatg caatgatgct
    29701 aatacaagta gatggatatg atgaagtatt aaaaagtgca gcagaagata agagagcttt
    29761 aattaatgtt gaagtagaga aaatactttc tgctttagaa ttaaattcaa atggtgcatt
    29821 gagaagaact tcaaaagaca aattcttctt ggtaatgcat aaaaaagagt taaaaaaatt
    29881 ggaagctgag aagttttcta ttttagatac aataagacat attgattatg gaaataatct
    29941 tcctgttact ataagtatag gaattggtat agatggagat acattaaatg agaacctaaa
    30001 acttgctacg ggtgctctcg atttagcact tggtagaggt ggtgaccagg ctgttgtaaa
    30061 aacaaaagat aaatttgtgt tttatggagg aaaatctaaa gctgtagaaa agaaaaccaa
    30121 agtaaaatcc agattaatag gtcatgcttt aagagaggtt atacaacaaa gtgaccaagt
    30181 ttatataatg ggacataaat atcctgatat ggatgctatg ggagcagcag ttggtgttta
    30241 tgatatatgt aaatcctgta acaaaactgc aaacatagtt ttacaatctg taaatgaatc
    30301 tatagaaata tttataaata aaataaatga aaataattac tataaaaagt tgtttattgg
    30361 aaaagaggaa gctattgaca actgcactaa aaatacatta gttgtagtag ttgatactca
    30421 tagaccaaat tatactgaat gtgaagaact gttaaagcta tcagagaagg tagtagttat
    30481 agaccatcat agaagaggtg tagagtttat aaatgatgca gtgcttttat tccatgagat
    30541 atatgtatcc tcaacgtgtg aaatggttac agagttagtt cagtatatgg atgaagatgt
    30601 aacaataaat aaacttacag ctgaagggct tttagcaggt ataagtctag atactaaaaa
    30661 ctttgcattc aaaacaggtg ttagaacttt tgaagctgct tcttacctta gaaaagttgg
    30721 agcagatact atagaggtaa agaaattctt caattctgat gtaaaagatt tcataataaa
    30781 agctgaaata attcaaagta ctaaaataat taataataga atatgtttag catattcaag
    30841 tactgagata gatagtataa atgttataat agctcaaact gctgatgagt tattaaatat
    30901 caaagaagta gaagcttcct ttgtattagg tgaaaaagat gatactatat ttataagtgc
    30961 gaggtcttta ggacaaataa atgtacatgt acttatggaa aaattaggag gcgggggaca
    31021 catagatata gctggagcac agttaaaaaa tgtttctcta aaagaagctt ataagatggt
    31081 aaataaaata atagaggagt atttggagga ggaagaatag atgaaagtta tattattaaa
    31141 agacgtaaaa ggaactggta aaaagggaga aatgaaagaa gtaagtgatg gatatgcaag
    31201 aaatttctta tttcctaaaa agatggctgt gcaagcagat agtgtagcaa taaaagaatt
    31261 aaatgaaaag aataaatcta aagaaataaa agcacaaaaa gagtatgaag aagcagtttt
    31321 attaggtaag caaatggaag aaattaatat agaaatatat tcaaaagcag gagaaggtgg
    31381 aagattattt ggttcaataa cttctaaaga aattgctgag caattaaaga aacaaaaaga
    31441 catagatgta gataaaagaa aaatattatt agatgaacca ataagatctt taggttcaac
    31501 tttcgtagaa ataaaaatac atcaaaaagt aactactaaa ataagagtgg atgtaaaaga
    31561 aaaacagtaa taactagagg tgattaagat ggaagatatg acgagaattc ctcctcatag
    31621 tgtagaatca gaacaatcaa tattgggttc tatacttcta gataaagatg ctataataac
    31681 ggttacagaa actataaagc ctgatgattt ctataaagag gctcacaaaa taatatatga
    31741 atgtatgata actttaagta ataaaggtga gcctatagac ttgataacat taacagaaga
    31801 actaagaaaa caagggcatc ttaatgatat tggaggaatc agttatatta caagtctttc
    31861 tactatagta ccgacgactt caaatgtaaa atactatgct gatatagtaa aagaaaagtc
    31921 tgtacttaga aagcttataa aagcttctaa tgaaataata aatctaggat atagtggagc
    31981 aactaagatt gaagatgttt tagaacaagc tgaaaagagt atatttgata tatcacagga
    32041 gaaaactagt gatgatttta aatctataaa cttagttttg atggatgcct atgatatgat
    32101 agaaaaatta tacactaaca agagtgatgt cactggtata actactggtt ttaaagattt
    32161 aaacaaaaaa ataaatggtc ttcaaaggac tgatttaata ttaattgcag ctagaccagc
    32221 aatgggtaaa actgcctttt ctttaaactt ggttcaaaat gcagccttaa aaggtgatgc
    32281 ctctgtagct gtatttagtt tagagatgtc taaggaacaa ttagtacaac gtatgttatc
    32341 ttcacaatct agtgtagaat taaaaaaaat aaagactgga acacttaatg ataatgattg
    32401 gcctagaatt atagatgcta tggcagtatt atcagatgcc aaaatacaca tagatgatac
    32461 tcctggtata aaaatatcag aactaaggtc aaagtgtaga aagttaaaaa tagaaaaagg
    32521 actagattta gtgcttattg attatcttca acttatggaa ggtgaaggta ataatgaaag
    32581 cagacaacaa gagatatcta agatatcaag gtcactaaaa atattagcaa aagaattaaa
    32641 ctgtcctgta gtagcactat ctcagttatc acgtgcacca gaacaaagag cagaccatag
    32701 acctatgtta tctgatttaa gagagtctgg agcaatagaa caggatgcag atatagttat
    32761 gttcttatac agggacgaat attatcatgc tgattctgag agtaaaaata taggagaagt
    32821 aataatagca aaaaatagac acggtgaaac tggttctgtg gaacttgttt ggcttggtga
    32881 agttcaaaga tttggggata agttgagaga cctataatct aacgaatatc cacagaacgt
    32941 cctttctttc tacaggaaaa atgtggatac atgtcactaa atatgtccaa acattgaaat
    33001 ttagctaaaa aactatccac actatccaca gatggcctgt tgataagtgt gaataagtag
    33061 ataaagcaag cttttggctt gctttatctg tgtataaata ttaattatta ggaggaataa
    33121 tatggaaaaa ataagcttaa aatatatata tcccaatata attaaagtac ttgatgaaat
    33181 aaacttattt agagtaattg acaataattt aagagaatct attgttgttt atgctaataa
    33241 tgtggataat cagtatcata taaacatgac taatacaaac tttggaaata taattaacat
    33301 atgtaaatta gaaaaacttt tagatgtgga taaatttatg gaaaaagtta taaaatatga
    33361 aaaagaaata atagagaaag aagagttttc aaaaatagaa gaatatatgt taaatattgg
    33421 agaatactaa aaaagttgaa aaaaatacga atgtttgata gaataagtaa gtaaagtgtt
    33481 cgagagtata taaaatatag aggtgaatta catgaaaaca gttgcaattg ttggttctca
    33541 atggggagat gaaggtaaag gtaaagttat agattatctt gctactcaag cagatgtagt
    33601 agtaagaggg caaggtggaa ataatgcagg acatacatta gttgtagaag gtaaaaaata
    33661 cgcattacat ctaattccat ctggagtttt aaatccaaat acagtgaata taatcggaaa
    33721 tggaatagtg tttgacccta aaggattttt agaagaattg gaaatgttta aaacggataa
    33781 tataagtaca gaaaatataa aaataagtga tagagcacat gtcatattcc catatcataa
    33841 agaactagat gcattgtcag aagaagccag aggcgattta aagataggta caacaaaaaa
    33901 aggtattgga ccttgttata tggataaaac agagagatct ggtattagaa tatgtgactt
    33961 aatggataaa gataaatttg ctataaaatt aaaagctcaa atagatgcta aaaatgaaat
    34021 agttaaaaat atatatggaa aagaagaatt atttgatttt gaaactatat ataacgaata
    34081 tctaggatat gcagagcaaa taagaaaata tgtggcagat acgtctgtta ttgtatatga
    34141 tgcagtaaga gcaggtaaaa aagtattgtt tgaaggagca caagggactt tattagattt
    34201 agatttagga acttatccat ttgttacatc ttctcatcca acatctggtg gatttgcaat
    34261 tggtgcaggt atagggccaa atatgataaa agacgttgtt ggtatagtaa aagcatatac
    34321 tacaagagtt ggagaaggac cgtttgttac agagcaaata aatgaaactg gagataagat
    34381 aagagaacaa ggacatgaat ttggggtaac tactggtaga ccaagaagat gtgggtggtt
    34441 tgatgcagtt atagttaagt atgcagctag agttaatgga ttgactagta tttcatttat
    34501 gttacttgat gtattaactg gatttgataa gataaaagtt tgtacgtctt ataaaatggg
    34561 cgataagata ataacggatt tcccagcttc attagatgat ttagcaaaat gtgaacctgt
    34621 atatgaagaa ttagatggat ggaatgaaga tataactcaa atagataact ttgatgacct
    34681 tccagaaaat gcaaagaaat atgtagcaaa aatagaagaa ctagttggag taagtgtaga
    34741 tatggtttct gttggtccaa atagagctca aactataata agaagaaata tatttgctta
    34801 atattttatc aattaaataa tttaaaatag ttgaagaaga gtatctcaag ataatgttta
    34861 tagttattag agatgctctt ttatatttga cttacattga ttttttatta agttaaagct
    34921 acttatacat attctaactg aaattaaagt tgaatttatg tagatacata taggtttttt
    34981 aaaaagaatt ttgttgaaaa taaatggcta aagatgattt taattatatt ctaaaaaaag
    35041 taaaaaaaac tattgactaa aaattatata gacgctataa tataacttgt gagtgaaaga
    35101 aacgacgaaa aaagtcgaaa aaatgtggtc tattagctca gtcggtagag cacctgactt
    35161 ttaatcaggg tgtcccgcgt tcgagtcgcg gatagatcac caaaatatgg ctcgttggtc
    35221 aagaggttaa gacaccgccc tttcacggcg gtaacagggg ttcaattccc ctacgagtca
    35281 ccagtatggg actatagctc agctgggaga gcacctgcct tacaagcagg gggtcacagg
    35341 ttcgagccct gttagtccca ccaaattttg aattagagat aaatactaga ttatatgctg
    35401 gtgtggctca acggtagagc agctgacttg taatcagcag gttgtaggtt cgattcctat
    35461 caccagctcc acaaagtaca taaattcaaa ttaatataat tttctatgtt acaggatact
    35521 tttaagtatc tttttttaat ttcattttta ttgtattaaa aatgaaatta aacatacaac
    35581 aaaattttga attacttgca atgtgatagt tttaaatata aaatttagaa tcattctagc
    35641 ataatattat gtaatatagc aaatttaatt tatagtatca ataaatatag actactaaga
    35701 atgtaaatga tttgttagat taaggtacat tagatatgta aatagaaaaa taaaaagtat
    35761 gttttaattt atgtgatata agttttaaac agagaagcaa gtttgctctt acctctctat
    35821 ttaaaaataa aaaaatgttt tttaagggct attttattta aatctttccc atctcaaatc
    35881 atctccagta aattctaaaa tcctaaactt atctaatatt ctagagagag ttctttgagt
    35941 gtaagtattt cctatttgag atggtgttaa gttggttgaa ataatgattt ttttaccagc
    36001 aacaagtctt gtatttacaa tattgaagat ttctccacta gtaaaagaat tattaagttc
    36061 agttccaagg tcatctatta ttaataaatc acaatcaaac aagtttttat aattatcttc
    36121 acttatttga ttatttgtgt ctcttctaaa tttataatct tcaagaatat ctaaaattct
    36181 aaaagaagtt tgatagatta caacattgcc tttatctaac aattcctttg caatacaatt
    36241 gcacatatag gtctttccta gtccagtaga accataaaac agtagatttt cactattatc
    36301 cttcttaaaa tcatgaacaa aattttcgca gatacttaaa ttatttagca tattttctct
    36361 aggagatatt tcaccatcag agcctttctt aggagaaaat atattcaagt taaaattcga
    36421 aaaattttcc tgacttaaaa tcctatctaa attagacatt ttataagctt catttacaat
    36481 ttcttgtttg aggcaagaac atttttctcc attaggtaaa aatcctttat ctttacaaga
    36541 aatacattga aactttattt ccaagtaatc aagaggtatg ttactttcag ctaaaagtct
    36601 ttctttcttt acttttaaag attctatatt ctctttagtc ttctttacaa tttcatcttt
    36661 agacttagga tttaaaagta ctatcttagc taaactgaga cctattttag aaatttcatc
    36721 atctatagat tttatctcag ggattctatt atatacctca ttttttctat gttctaataa
    36781 gagttcatta tcatctcttc tcttagcata tttagcaagt atttttctta ttttatcctc
    36841 attcatttaa tcacctactt aaacttttct ttttgacttt ttttaataat ctcatcgagc
    36901 tcatcagagg tatactgagt gaatgtttcg ttgaaattat gaaacttagt ttttttgtaa
    36961 gtattgttgt tttgagtagt attaatctgc ttcttattaa tattctcctt aactatacgt
    37021 tcttcctctt tttgctttaa atcatttaaa ttttttatat ttttttcatt ccaattttta
    37081 attataccat ttatataaga tatacttggg tttgaaatat tcttagactt agaacatgca
    37141 tttattatca aatctatatc catattaaat ttatcaaacc aggtgtccat aagttctttt
    37201 tctgattttg atggttgtct tgaaaatccc aattcattga aaatcgtttt atataaaata
    37261 tatcgttcac ttcttaccaa aaagctttct tcaacatctt ttggcgtata taaatttgaa
    37321 tcataccaat ttctaataat gccttcaatg tatttaactg gctttgatgt accagtttta
    37381 tctttgacgt attcatatgc gcaaagtatc atatcggggc tcatattgta tttattcatt
    37441 atatccataa tactcatctt ttcacttggg tcgagatatc gcccaactat tttatttata
    37501 gaattaaaca tttttctaat acttggattt tcagaagtag atacaacttt atctgtatta
    37561 gattttatag atgaattatt gcttaatata ttctcaatat agaaattttt taaatctaaa
    37621 aattctattg aataattaaa attatcatat tcttcattgt catgtatttt tataatcttc
    37681 ttttcttccc agaatttcca agcagataac acatcagaca atggtatatt taggtttttg
    37741 gctattgaat tattgtcgaa cttaggatta gaagtaatat cacatgcttg tctatatcct
    37801 aaaagataaa cttttacgta taacccgtcc gccattggca taaatatatc tataaagata
    37861 ttgggaatag tgatttcacc taaatctatt tcattgcttt ctttaaaaaa cattttatca
    37921 cctcagatta aattatatca ttttttatat tatatttgtc tgtaaacaaa taaaaggtca
    37981 caagattagc atgtaaatat tttctaaaag tattcatttt gaaaaggagg agatattttg
    38041 gttataaaat tcaaccaaaa agtaagaaga acattatcag tagcgattct atttatggta
    38101 ttaataatag gttgctttat agaaaaggat gacagtttag aaacatacaa agaaaaaact
    38161 aattcaaaaa taaatcagta taatatggat gttatatttg atgatgagac taagaggtta
    38221 atgtgcaatc agaatgttga ctacataaat aatacaaaat caaacataga taaaatatat
    38281 ttccatatat atccgaatgc tttttccaag aaagattttg ctccttttga aaaaagtgaa
    38341 atgacaaggg cttatcctaa tggatttaac gaaggatata tagatataaa gaatatatta
    38401 aataataata gtaaaatgga gtataaaatt aaaggagaca aaaatgacat attagaaata
    38461 gaattaggga aagagttaaa accaaatgaa agaatgtcat tagatataaa atataacgta
    38521 aaaataccaa attcaattgg aagatttgga tatggagaaa atactataaa tgttactaat
    38581 tggtttccta tagcttgtgt aaatgatgaa aggggatgga atttaaagag ttatgaaact
    38641 attggcgacc cattttatag tgagactagc gattttcatg tgaaactatt gattccaaat
    38701 aaatataaaa ttgctcatac aggaaaactt attgatgata aacatgataa taagaaaatg
    38761 ctatatgaaa tagaagctga aaacgttaga gattttgcat ttatactaag tagtaaattt
    38821 gatgtaaaca aagtagattc aaagggagta gctatcaata catataattt aaataaaaag
    38881 ctttctaaaa aagcaactga agtggcaaaa gattcaataa atatatttag tgaattattt
    38941 ggaaagtatc cttacaaaga attttctgtt gtagcaagtg acttttttat aggggggatg
    39001 gaatacccta tgcttgttat gatagaccaa agtttatata atgaaaaaaa tgaattttta
    39061 ctagaatatg ttattgccca tgagacagca catcaatggt ggtattctgc tgttggaaat
    39121 gatgaaataa gtgaaccctg gttagatgaa gcacttactg aatattctac aatagtttat
    39181 tttgaacaaa agtatggtaa agatatggca aacaagctta taaaaactat ggagatacag
    39241 acaaaaagtt atttgagtga aaatatattt aagccagcaa atgagtataa aaattctact
    39301 gaatacagct tgaatgttta tacaaaaggc gcaatagcat ttaatgaaat aagaaaagaa
    39361 gttggagata aagtattctt tgagacttta aatgagtact ataataaata taagcataaa
    39421 aatgctaatg gaagagcttt tgtggaacta tggaatagta aaggtgtaga tataaataag
    39481 attataagtg aatgtaagta aatagtgaat gtaagtaaat tttgtgcaga gtattaaatt
    39541 ttatttaata ctctgttttt ttggtataat ataatttata aggcagaaaa agaggtgaag
    39601 gaatgctaaa gtattgttca gtagggagtg gtagtagtgg taattgccac tatatagggt
    39661 ataaaaatac taatatacta gtagatgcag gattaagtgg caagagaata actacaggtc
    39721 ttaaagacat tggtgtagat gcagataaat taaaaggaat atttataaca catgagcatg
    39781 ttgaccatat aaaaggagca ggtatattat caagaaagtt tgatatacca gtatttgcta
    39841 atataaaaac atggtgttct atgaaggaca aattaggtga catcaaagat aaaaatatga
    39901 aagtatttga aaatgataaa acctactcat taggtgatat catagtaaga cctttttcaa
    39961 tagaacatga tgcgtctgac ccagttggat ataattttta tacagagagt gatgaaaaaa
    40021 tgtctatagc tactgatata ggatgtataa ctcaaaatat aaaaaaacat ctatataaat
    40081 ctaaattagt agtattggaa tcaaattatg accctaatat gcttatgatg ggttcatata
    40141 catatgcttt aaagaaaaga gtaatgtcaa gtactggtca tttatccaat gaagatgcag
    40201 ctaatttctg cgttgaactt attaatgaag gtacagaatc tatattatta gcacatttaa
    40261 gcaaagaaaa taattttcct gagttagcgt atgagacttc aaaaggagta ttagcatcaa
    40321 atgatatagt agttggacaa gatgtaaaac tagatgtact atcacgaaat gatgtttcta
    40381 atgtttatga gatgaagtag aggtgaataa ctttgctaaa gagaaatttt gaaaatgttg
    40441 aggataataa aattttatac tctataaagc agggtatgat tttagcgata cctgctatta
    40501 tgactggttc aactgctctt gtaattttga atcttccaat aaaggcttat caagaatatt
    40561 tatcaggctt gtttaatgga gaggttacaa atattcttaa ctttataaat gattctactt
    40621 taggaattat ttcattaata atattattaa caataagcta tagttatgga aaaatatatg
    40681 ggagcaagta tacagtactt gttcctatag ttgcaatgtg ctctttttta gtattttcac
    40741 atggtaatga gcttaattct tatatagaaa tatttaaaac aaagtggtta tttacatcta
    40801 taattgtttc tatgacatct tctgtattgt ttgtaaaact tacagaatct tttgttacaa
    40861 gtgtaaagtt tcatacagaa ggggctgatg cagactttaa tatggtagtt tcggctatag
    40921 ttcctttcat aatagtagta tttttgtttt ctatttttag agtggtaatg ataagtctaa
    40981 ttggcagttc aaactttcaa gatatatttt ataatttatt ttcaaatgtt tttaataaaa
    41041 tgggaacaaa ccttatgagt gctctgttgt ttattttttt aatgcacttt atgtggtttt
    41101 ttgggattca tggtagtaat gtattagata ccgtcgcaaa aaatttattt gaaaatagta
    41161 tggcaattaa cataaattta gttaataata atcaattacc aacagaaatt tttactaaga
    41221 ccttttttga tacaatggtt ttattgggag gatgtggctc tttactatgt ttagtaattg
    41281 caatttttct tagtgaaaaa cgtataaatg taagaaagtt agctaaaatt gcttcaatac
    41341 cagctctttt taatatcaat gagatgctag ttttcgggat accaattgtt tttaactata
    41401 ttatgtttgt accttttgta attactccta taatcttaac cgttacaagt tatgtggcta
    41461 tgtctacagg tattgtacca tgtacagttt cagctgtaga atggacctca cctatatttt
    41521 taagtggata tatgtctaca ggttcaataa gaggtagttt gttgcaagta tttaatttat
    41581 gtgttggtgt tatgatttat attccgttta taaaaatgtc gcaaaataga tatacatata
    41641 tgtttaaaaa taatatagaa aatttaacaa acttattaaa aaggtatgaa ttaacaggtg
    41701 aacagcctaa tcttctaaac cataatggta aaataggttc aatttcaaaa atgttggcat
    41761 cagacttgaa gtttgctatg aaaagaggag aaatagagct tttttatcaa ccacaagtca
    41821 attataatgg aaatgttgtg ggagcagagg gattacttag atggaaacat tcaataggag
    41881 ggttcattta tccaccacta gttataattt tggctaaaga agaagggttc ttagatgagc
    41941 ttggagagta tattattaat aaagcatgta ttgatttaaa gaagagtgaa aagctattga
    42001 gaaatcctgt taagttctct gtaaatatat ctccagacca acttgatgac cctaagttac
    42061 cagagcaaat aaaaaatatc attagtagta atgatataaa tcctaatatg ttaggtatag
    42121 aaataacaga gcaaattgca ttatcaggtt cacaaataat tattgaacgt atcaatgcga
    42181 tacataactt gggaataaag ttaattatgg atgattttgg gatggggcat agctctctta
    42241 tatatcttca aaataataac tttgatatag ttaaattgga tggttcatta gttaaagaga
    42301 tacttacaaa taaaagaagt agtgaaatta taatgactat tgtaaatctt tcaaaaaatt
    42361 tagattttga tatagttgtt gagtatgttg aaaatataga ccaaagggat aagttatatg
    42421 gtttaggatg tgaaatatat caaggatatt attatagcaa agcaatacct tttgaagagt
    42481 ttgtagaata tgcaaatcaa gaaagagaga tataatttta taagagcttg taaattctag
    42541 taatgcatag atttgtaata aaattaagtt taggagaaat atatgaatat aagtatagta
    42601 gtagtaggta aaattaaaga aaaatattta aaattaggta ttgatgagtt taagaaaagg
    42661 ctttctaagt attgtaagtt agaaattata gagttggatg atgaaaaagc tccagagaat
    42721 ttgagtgtta aggaaatgga aattataaaa gacaaagaag gaaagaaaat tttagggaag
    42781 ataaagcata atagttatgt tatagccttg gctattgatg gtaagggttt atcctctgaa
    42841 gagcttgcta agactatgag tgatttagca gttagaggta atagtagtct ctgttttata
    42901 ataggaggtt ctttagggct ttctgatgag gttttaggaa gggctgatta taggttatcc
    42961 ttttctaaga tgacttttcc tcatcagatg atgagattga tattgttaga acagatttat
    43021 agggcttata ggataaataa tggagaaccg tatcataaat aaatgatacg gtttttgtta
    43081 atttgacact taataatatt aaaataacaa aaaagtattg aaagtatatt gcatttaagg
    43141 tagaattaaa taaaatatta taacattata atgtttatat ggttgttaat aaaaatttgg
    43201 aggaaaatat atgataaaaa taatgttggc ctgttcagca ggaatgtcta caagtttatt
    43261 agttactaaa atggaaagtg cagctaaaga aaatggtata gagtcgcaaa tttgggcaat
    43321 accagaatca actatacaaa atgaaataga aaaatgtgat gtattattac taggaccaca
    43381 agttagatat gtattaccta aggctcaaga aattgctaag ccatataata taccagtaga
    43441 agttataaat atgatgcact atggaacagt taatggagaa gctgttttaa atagagcgat
    43501 agaacttaac aacactaagt aatataaatt ataatgtatt tttaatatat aaattgggag
    43561 aatcaaagga tggatgaaaa gactatagaa atatctttta atataatagg ttatgcaggt
    43621 gaaggtaaag gattagcttt tgaagcaata aaagaggcta agaatggaaa tatagaaaaa
    43681 gcaaaagaat tattaaaaga gtccagggaa gttataaata aagcacatag atatcaaaca
    43741 gaattaatac aaaacgaagc tagtggaaac aggactgaaa taagtgtcat acttatacat
    43801 gcacaggacc acttaatgaa tggcatgaat tttcaacagt tagctgagga aatcgttgat
    43861 ttacatttga aattacaaga taaataaaaa ttaaagataa taaattaaga gagttcttaa
    43921 aagatacatt atgtgtagca cactaattgt tagattattg attcaatatt tagtgagtaa
    43981 tacattagga ttattttgag gactcttttt atatttagtt taaagttaat aaatatttat
    44041 tattaataat ataagattat atgttataat attataacat ataatttaag aggtgaatca
    44101 tgttaagaaa tcaaccatta tatatacaag ttgtagatat attaaagcaa aaaatattaa
    44161 ataacgaata taaaattgat gaaaatattc caacagaaag ggagttagag caagagtttg
    44221 gagtcagtaa aattactatt agaaaagcta ttgagatatt agaatcagaa gggtatgtag
    44281 agaaaaaaag tggaaaaggg acaaaagtaa taagtaatag tctttttaat aagctatcaa
    44341 aagcagagtc tttttcaagt atacttttat ctaaaggtca taagttatct aaaaagacta
    44401 tttcaattga aaaaataata aatgatacaa attcacaagt atttagtata tttggagaaa
    44461 aatgtagcaa gattactaga atgtattact tagatagtaa gccatatata ttttttactc
    44521 attatattcc ttttgatgaa aatctaactg ttgaaagttt taataatgaa agttctttat
    44581 atatgtactt atataggaga aatataaata taactagatt tgaagatgaa ttttttatag
    44641 aagaatcaga actagaggta tcaaaggctc taaatctagc taaagacata ttattaggaa
    44701 gaaaaagaaa gacctatgat gagaatgata atatagttga gctatcattt gcaagatata
    44761 atacagaagt acaaaactat gtaattaaat acgaaatata ataagaatcc tgagtttatt
    44821 gaaatgataa tatgctcagg atttttgttt agttgtaaaa ataaaaaata ttataacatt
    44881 ataatgttta caactaaaca ttataatgtt ataatatttt taataaacaa gtgatattat
    44941 caattacata aaaattagtt tatgttatga aatcgttatt gcattataaa taaaggataa
    45001 tatcaataat acagggggat aactatggaa aaattcgcaa gttttttaga gcgcaagatt
    45061 atgcctgtag cagcgaagat aagtaatcag agacatatga gagctgtaag agcaggtata
    45121 atagcaacat taccactaac aatagtgggg tcatttttca caatattatt aaacatacct
    45181 attgatgctt atatggattt tatagctcca tttaaagcaa tattagatat accatttaga
    45241 tatactgtag gatttttatc tctatatgct acttttggga tagcatcatc acttgctaaa
    45301 agctacgatt tagatacaac aggtgttggt atgcttgcag ttatggcatt tttagtttct
    45361 acaatagttc caactcaagt agttgaacca gtaggtggag ttatagaagc tggtagatgg
    45421 atggatatgg caaaacttaa ttcgccatca ttatttggag ctatcgtaac atcattaatt
    45481 acagttgaaa tatatcgttt tatgaaggaa aagaatatta caattaagat gccagcagga
    45541 gttccagtag aggtttcaaa ttcatttact gcattattac cgacagcagt aattttaatg
    45601 ttattctggg taataagaca tattttagga tttgatataa gtgttgcact aagcgctatg
    45661 ttatcacctt taaaaggatt cttatcagga aatagtttag gtggtgggtt actgacagta
    45721 ttcctaataa ctttattctg ggtacttgga atacatggtc cagctataat ggggccagta
    45781 ataagaccta tatgggacat gtctatagca gaaaatataa ctgcattcac agaaggagta
    45841 tcagctcatg caatgccaaa catatttaca gaacaatttt tacagtggta tgtatggata
    45901 gggggagcag gggctactct tgcattagtt gtaatgttta tgttttctaa gtcacaatat
    45961 ctaaaaagtt taggtagatt aggattttta ccagggttat tcaacataaa tgaacctata
    46021 atatttggag caccaatagt tatgaatcca atactaggga taccatttat aattggacct
    46081 ataataatga caattctatc atatgttctt actattacag gggttatacc tatgatggta
    46141 gcaagattac catttgcaat gccagcacca atagcagcag taatgagtac taactggagt
    46201 atattagcag gtatcttagt attaatcaac tttgtgatat catttgctgt ttattatcca
    46261 ttcttcaaag tttttgaaaa acaacaatta caaagagaac aagaagaaat gagtgaaaat
    46321 ttataaaaat acatagatat agaggttttg tactatataa aatatagaaa aaacttataa
    46381 gttattaagg gtgaaggtag gaggaatgac ctttgccttt aattttatat attttaaata
    46441 atgtaatttg aggaggagaa agatggaaag aagattagga atatcagtat atccagagca
    46501 tagtaacatg gaagatgata aggcatatat aaaaatggct tcaaaatacg gatttaaaag
    46561 aatatttatg tgcatgcttt caattacaag acctaaggaa gaagttaaaa aacattttaa
    46621 agagattata acctatgcaa gagaattagg atttgaagta atccttgata tagctccaaa
    46681 catatttgat atattacaaa tatcttatga tgatttaaca ttttttagtg agttaaatgc
    46741 tagtggaata aggcttgact atggatatga tggaagtaaa gaagctatga tttctttcaa
    46801 tccatatgat ttaaaagtgg aactaaatat gagtaatgat gtagcatact tggataatat
    46861 aattacttac aagccaaatg taaataatat atatggttgt cacaattttt atcctcaaag
    46921 gggtacaggc ttgccatatg atttttttgt aagatgttca aatagattta aaaagtatgg
    46981 aataagaact gctgcttttg ttaattcaaa atatgcaaca atcggacctt ggaatataaa
    47041 tgatggactg tgtacgcttg aaatgcatag aaacttagat attgctacag caactaagca
    47101 cttattcgca acaggattga ttgacgatgt aattgtaggg aatgcatatg caagtgaaga
    47161 tgaattaaaa agaatgtctg aagtaaataa atatcaagtt gtatttaatg tagtaactga
    47221 ggaaaaaact tctgaagtag aaaagacaat aatggcaaat gagcaacact ttagaagagg
    47281 ggatataacc aaccaagtag caaggtctac agaagtaaga aaaaaatatg ctaaagaaaa
    47341 tttccctaag catgataata cgaccatctt taaaagagga gatgtagtga ttggtaatga
    47401 tgactttgga aagtataaag gggaattaca gttgatactt caagattgtg cagatgaaag
    47461 aaaaaataag gtaggtagaa taaaggaaga cgaaataatg cttttagact ttattgaacc
    47521 ttggagtaaa tttaaactta ttttagaggg agagtaaagt gaagatagac atattaataa
    47581 aaggtggaaa aacagtagat aaaagtataa ttgatatagc tatattagac gataaaataa
    47641 tagaagtaaa aaatcagata gatgattcta agtatcaggc aaatcaaatt ataaacctag
    47701 atggagaaaa atttattagt gctggttgga tagatataca tacgcattgc tacgaaagac
    47761 tagaccttta taaggattat ccagatgagg ttggaataaa aagcggtgtt actactgtag
    47821 tagatgcagg aacaacagga gctttagata taggtaaatt ttatgaagat actaaaaaat
    47881 ataaaacaaa tgtatatgct ttaataaata ttgctaagca gggaataaca tctcaagatg
    47941 aactttcaag tatgatgaat attgatgaat atgaacttaa aagagcagtt aaaaaataca
    48001 aagattttgt tgttggaatc aaagctagaa tgagtaaaag tgttgtaatt tcaaatgatg
    48061 ttgaaccttt aaaagtagct aaaagaataa aaaatgaact taatctacct atgatggttc
    48121 actttgggag ttctcctcca acgatagagg atatatttga ctatatggaa aaaggagata
    48181 tattaaccca tatatataat ggaaagccaa atggaatact tagaggcaat gaggttaaaa
    48241 aagaaatcat agaagctaga gaaagaggta taatccttga tgtaggtcat ggaaccgaaa
    48301 gttttagtat ggatattgca atgaaatcta aggatgcagg aatttttcca gacactataa
    48361 gtacagatat atatattaaa aatagaataa atggtccagt gtataatcta tctacaacaa
    48421 tggaaaagtt tatatatatg ggctattcac ttgaagatat aatagataaa gttactaaaa
    48481 atgcagcaga tgcaataagt ttaaaaaata aaggtttaat aaaagaagga tatgatgctg
    48541 atttaactat atttgatgtg gttaatgaag aaaaagaact tcaagattct ttgaataagt
    48601 cagtaatcac aagtacgtct ataaagccaa gagcagtagt agtcaatgga gaatatttaa
    48661 atataggtaa gtctatagga gagaatgagt agaagggaga aactattgta tgagtagtat
    48721 atttgaaaaa tactctgtaa gacgtgttat aaatgcttca ggcaaaatga ctatactagg
    48781 agtatcaaca gtagataagg aagttattga agcaataggt gaagggtgta aaaatttctt
    48841 tataatagaa gaacttataa ataaaacagg tgaatatata gcaaatttat tagggtgtga
    48901 aagtgcacta atagtttcta gtgcatctgc tgggattgca cagagtgtgg gagcaatgat
    48961 agcaaaagat gatatgagtc tagtttacaa tgtaaataat cctaagaaac aagttaaaag
    49021 ggaaataata attccaaagg ggcataatgt tgattatgga gttccagtag aagtaatgat
    49081 aagacttgga ggaggagaag ttgttgaggc cggctatgct aatatgtgta acaaggaaca
    49141 tataataaga gagataaatg aaaatacagc agcaattatg tatattaaat ctcatcattg
    49201 tgttcaaaag agtatgctaa gtgtattaga tgcagtacaa gttgctaaag aatataattt
    49261 acctttgata gtagatgcag cagcagaaga agatttaaat gtatattatg aattgggagc
    49321 agacctagtg atatacagtg gtgctaaggc tatagagggt cctagctcag ggttagtaat
    49381 aggtaagaaa aaatacatag ataatgtaaa gcttcaatca aagggtatag gaagagctat
    49441 gaaaatagga aaagaaaata ttgtaggtct aacatgtgca attgagagat atataagtaa
    49501 tgataaagta actttaaaag aaatggagga caagctaaat ccatttatag acaagataaa
    49561 tactataaag ggagtgagtg ctagtataac tagagattca gcaggtagag aaatacttcg
    49621 tggagaaatt gactttaatg aagatataat aaataagtca acacaacaaa ttataaatga
    49681 acttagaagt ggagagatag ctatatacac tagagactat aaggctaatg aaggcaagat
    49741 tgagattgat ataagaagtg taactggaag tgatttagat actatttata ataggataaa
    49801 aaatatagta gaaagttaga gtgtagagta agtgacatta taatgattta ataaattaaa
    49861 ttttaccaat ggaggggata aatatgaatt gtataccaca atattataaa aatagagttt
    49921 gtttaaatgt tcttgcagga agcataaaaa atgctaaaga agtatatgat gcttgtgatg
    49981 ggtatgtatt gataggagta ctatcaaaga attacagtac tgtagaagca gctattgaag
    50041 atatgaaaaa atactcaaag gaaatagata atgcaatatc tgtggggctt ggagctggag
    50101 acccaaatca gtcaaatatg gtatctcaga tttctaaaga acttcagcca caacatataa
    50161 atcaagtgtt tacaggtgtg gctacgtcta gagcattgct tggtcaaaat gatagtataa
    50221 taaatggatt agtttctcca actggtaaac caggatttgt aaaaatatcc acaggtccat
    50281 taagttcaaa agaaaaagat ggtatagttc ctatagaaac agcaatagct atgatgaaag
    50341 atatgggagg aagctcaatt aagttttttc caatgggagg gcttaaaaca aaggatgaat
    50401 atatagaagt tgcaaaagct tgtgcaaagc ataattttta tttagaacca acagggggta
    50461 tagacttaga taacttcaaa gagatagttc aaattgcact tgatgctggt gtagaaaaag
    50521 ttatacctca tgtttataca tcaataattg ataaagaaac aggtgaaacg aaagtggaag
    50581 atataggagt actttataaa ataatgaaag aattattggg atagatttat gaatatatta
    50641 gcttttggtg aaataatgat gagactttca gtacctgact acaagttctt aacacaaacc
    50701 aatgaactaa attatataat tacaggcaca ggattaaata tattatctgg acttaaaaac
    50761 tttggataca atacctatat gttgacaaag ttgcctaata ataatgtagg taaagcatca
    50821 agtgcaaata taagaaagct tggagtaaaa gatgacttta tcacatatgg agggaatcat
    50881 ataggagtgt attttcttga aaatgggtat ggagaaagac cttctgaagt gacttatttg
    50941 aataggttaa atagttcatt ttgtgagagt aaattacaag attatgatat tgataaatgt
    51001 ttagaagaaa tggatatagt ccttatttgt ggtattgcta tgcaacttac agattcaatt
    51061 aaagagattg ctttagaact agctagaaaa tcttatgaaa aggggataaa agtattcttt
    51121 gattttaatt ttagacaatc attaaatcca gaaaggactt atgatgattt agtaaatgat
    51181 tataagaaaa tactaccata ttgtcatggt ctatttgcta gttatagaga tataaataag
    51241 atacttaata tagatagtct aaatataaaa tctagttcag aattgattaa aaaagagtat
    51301 gatataggta ttgtagctgg aactatgaga agatttgatg atatgaataa tagatttata
    51361 aagggatata tatcaaatga tgatggttat tttgaaagta gggagtataa gttagaaata
    51421 tatgacaggg ttggtgccgg agatggatat gtagcaggaa ttatatattc atatttggaa
    51481 aatatgaaga gtgaagatat agttgagttt ggggttgcta gttcggtgtt agctcataca
    51541 acttatgggg ataattcttt agtaagcaca ggtcatgtac ttagacttat gaacaatgaa
    51601 aaaatagata tattgagata atacatttgt atataataaa atttttatct tttttagaca
    51661 cacttttgac ttgtttatat ttgttaaaca gagttatttt taatgattat aaatattaaa
    51721 ttaaaagtta aataataaaa tagtagaaaa tagcattaac tatagaaaaa atggttaatg
    51781 ctatttttat cgttaatatt gattaatttt atattataga aatgaacttt tctaatgctg
    51841 gatttgtatt ttttttattc catacaacta caacttcaat tctattttct acttctttta
    51901 taggtactat tgcaatatca cgttctatca ttgtatctgt aacacaaaat gaaggtaaaa
    51961 tggatattcc catgttagaa gataccaatg attcaatagt attaagatta tttgaacgtt
    52021 gtaccacatt aggtacaaac cctgcttcac gatatctatt ctgtatcatt gacttttgtc
    52081 catactcatc ccctgtttct tttacaaaaa taaatttatc atgttgtaat tcaattaaat
    52141 cgatagaatc ctcattgtaa agtggatgac caggaggtaa aagagctacc aaagaatatc
    52201 tttctacagt tttatattca aaatctttta atggttgatt ttctggatta ataacaaaag
    52261 cgaggtccat agaattattt tttactaagt ttaaaagttc ggttatttca ttagtacaaa
    52321 tatccataga tatattaggg tatgtattag aaaattcttt taaatattgt tgaagtttgt
    52381 ttttttcata tcctattaag gttccaatgc tcaaagttcc aaaaaaacca tgtgcaaatt
    52441 gttgtgtttt tgcaatagca tcattgatat tttttattat agtacgtgcc tcagataaaa
    52501 aaacttttcc agctggtgtt agttcaacat gacgtttact tcttgtaaat agagttacat
    52561 ttatttgttc ttctaaagct tttatttgct gtgtaacagc agtttgagaa atataaaatt
    52621 tttctgctgt tttggtaaaa cttaaatttt ctgctacaga tataaaatat tctaattgtt
    52681 tagtattcaa ataatcaccc ctatttaaac ttgattgttt gtaaacctta tttatctata
    52741 attaaagctt attatagtat aagaaaattt acttttaaag aatattagaa aatatttgta
    52801 taaaaatata tgttttaagt atatctttac attagatttt ataaatttat taataagaat
    52861 aacttatata ttccaatgaa aacgatattg gatttaagta agtttgtctc ataaaatgaa
    52921 agtatatcaa ttgataatac tttaaataag aagggagaaa aaatggaaga taaattttat
    52981 gcaaaaggca acggaaataa cggatatatt aaaaatcttg aagtttgttc ctttaataac
    53041 ttagatggaa cttgtggaat gtttcaaatg gctctgtaca aaagagatga aaaatactat
    53101 ttatatggat gctgttttgg aggaaataaa aaaaatggag taatgattag cgatattaca
    53161 gacccttata atccacaatt tataaaacat tttcaaatgt tagaccctaa agagtatcct
    53221 acaacaacaa ctcccaaaat tcaaatagca gatgatttaa tgatagtagc aatgagttgt
    53281 ggaagtggac caggagcact tgttgaccaa gctaaattag caaatattaa gtgtgaagca
    53341 ggaattagaa tatatagttt aaaagaagac cctttaaatc ctaagttttt aggatattgg
    53401 gattgtggct taaagcatgt aatgggtgtt catagattca tgtacaatgg tggaagatat
    53461 gtacatttat caagtgattg tgttggcttt gaaggtctga tttatagggt catagatata
    53521 ataaatccta ctaatccagt ggaaataggt aaatggtgga gaccagacca atatgcagat
    53581 ggatatccaa atagaacttt tgatgcagga gcacctcatt gcccagaatt tatggataaa
    53641 ggatggcttc atggacctcc atttgtaaga gacggaaaag catattgtgg ttatggagga
    53701 gctggtttag ttgtattaga tgttgaagat ttaacaagac caagatgctt aggtgaattg
    53761 ccatttatgc ctgcattttc tagtagactt gcaggtgcaa gaactcatac agcattacca
    53821 ttgccaggaa gagatttagt cgttgttcaa aatgagggag aaagattcca gttctttaaa
    53881 ccagataaca ttacagatgt tcaagctatg aataatatac atatggttga tgttagtgac
    53941 ccaacaaaac caacattaat tgctcaattt ccatatcctg aagttccaaa agatttccct
    54001 tatcctaact ttaatgttgc aggattagga aaaccagggc catttggtcc acataatctt
    54061 catgaaccaa tggataataa accatggtta gagcaaagag gagatagagt atattgctgt
    54121 tatttccatg cagggctaag ggtttatgat gtatcagacc catattatat caaagagcta
    54181 gcatatttta taccaccaaa tccaaataaa acaccagaag aatcttattt cccaggattc
    54241 ccaggaccac gcttggcagt aacagaagat cttatcgttg atgatagagg ctacatcatc
    54301 atagatgctt tagatgatgg attctatata ttaaaaatga aagaagatta aataaatact
    54361 aaagagggag agttgaaaat gaaaatacta ggtatttctt ttggaacaaa aaatggaaat
    54421 aatgacacaa tgtgtaaagt tgcacttaaa ggtgccaaag aagcaggggc tgaagtagaa
    54481 tttattcaaa tgtcatctat taacattaaa cattgtactg gatgttgtgc gtgtgttaaa
    54541 actttattat ctgggaaagg tagtatgtgt gtattaaaag atgattttga atggttgctt
    54601 gacaaaatga aagatgcaga tggtatagta gtttcagacc ctatttttga agaaggggca
    54661 tcaggattat tccatactat aatggaccgt tttggaccca gagcagatag aggaaataac
    54721 attataggaa caaaagttgc agaagctata ggaggaaaaa ttccagattc aagaatgctt
    54781 aatgataaag taatatcatt tatgggaata ggaggttctg actggggtac aagagttcaa
    54841 tgtgaacatg ctatgctagc tctcatacca atgtggaaag ttatagataa tgcttggttc
    54901 ccatgggcaa aggaattagt aatggatgat acaaggcttg ttcaagttca tcaaattggt
    54961 ttaaatatag ttgaagcagc aaaagatttt gaaaaagctt catatcaagg agaagaaggt
    55021 gtatgtccac attgccacaa tagattattc taccttgagc caggtactaa aaaggcaatt
    55081 tgtgctctat gtggtatagt tggagagtta gatactataa gtggaaaaac tatatttagt
    55141 tttccagaag agcaattagg tcatgctcat gatactttac caggtaagtt tatacatggt
    55201 gatgatatta agaaaatgga aggtcattat gcagaagttc gtaaaacaca agaatttaaa
    55261 gaaagaaaaa catcttataa ttttatagag acattaacta aagaaaaaca agctggagtt
    55321 tcattaggat aataattaaa atactaagac tcttttttaa gggatgttag atgttatagg
    55381 aggcttattg tatgaatgaa aagccaagtt ttaaacaaat tgaagttatt ttagcagtta
    55441 tttttttggt acttacatat tacaaggtta gattaactcc agcatttatt gttatattta
    55501 taccactata tttaagttat tttgcagtat ctatgattgt aaatcaaata gcaattaagc
    55561 tattggagat aaggcaagct agggaagcta ctaattacaa tataggaaat ggatagaaag
    55621 aaaaaagaaa tattaacact gtctatgggg attgctttac tacctccttt atgggcagta
    55681 ttagcacctt atataggaat aaaaactgga gctgtagcac taatctgtgc aggattatat
    55741 gtaactaatg gtaataaaca agaagatgga ttaaaaataa tgtttggttt ttggtgtgga
    55801 gatttatggg cagtgttagt cattttaatt atgggatata tgaatttcaa tcaaaaccta
    55861 gaattatttt taacacttag tatattaggt ttttttgcag ttgtaattgc atccttattt
    55921 gaaaaaataa ttttcctacc atcatggctt tgtggttggg ctataggtct aactattatg
    55981 acaggtgaaa atattattaa tttacaagat atttgtattc aaattgctgt agctatggca
    56041 gtaggagtat ggtacgtggg tgcaggtgta gatttgttta caatatatat tttgagtaaa
    56101 gataggaaaa agggaaattg aaagcatgtg aatatacttt gattatagga ggatggctat
    56161 gggttttgaa tttaaaataa tgagaagttt aatatatgta ggacttgcca aggaagaata
    56221 tagacctaag ctaatggact ggttatatcg tcaccatatt ccagatagta ttagcacttt
    56281 tggaccatat tgtactaaat atgcctttta tcaagcatat cctacaccaa atgaaggtga
    56341 gcgttttggt gcacgtaaga tgcaactaac agaacattat tggcttgtag atgaacatat
    56401 gcctgagatg gcaaatagaa ttatgacaga atatatgcct atggatgttc tacgttggca
    56461 agggtgtata ccagatgtag aaaataaaag ggttcatgaa aatgcagaaa gtggagatgc
    56521 aggacgtgca gtaggtggag ataatggatg tccaccattt atatttgcct ttgttccaat
    56581 aaactgggaa gaagacttta gaggaaaagg acgtactgta caagatggac caaactatcg
    56641 ttggcaattt atgattaagt atccagatgg tatctctaaa gaagaaggag aaaaatggtt
    56701 ctatgatgag gtagtgccat actttacaaa ctgttgctat gttaatcgtt ttgtcagtag
    56761 taaaataatg attaattatg gagcaactgc ttttgaccgt gtgtcagaac tatggtttga
    56821 aggggaagaa gaatggtata aagctgtggt tgaagagaca aagtcgttta ttaaaaaacc
    56881 agaatgggca caagaagagg agttcccata tttaaaacca caattcaata tcgcatcagt
    56941 attcttaggt gatatagcaa ctatggatgc atactcacag tatcgtggat atataccaat
    57001 gagataaaaa ttatagtttg tgataagtag agaaggcatt tactcttact ggtagaagaa
    57061 gacttattgt atccttaaaa gtaggtgaat atatagtttt atatttaaat ttatataaaa
    57121 ctaagactaa taaatatgaa acaatagaat tagaataatt tgataatatt tgttaaaaga
    57181 gcatttagaa tgtgtttaaa gattaagata ttccttttat ggtagcagat agttgaaata
    57241 ataaaactgt tatcatgaaa ggaatatttt tatgtatagg aaatttttaa aaataaaagt
    57301 taaatatgtt taagaacatc ttaaagtgaa agaatcattg ttagaaatat gtagacaata
    57361 tagtatttat aacgtatcat attaacaagt ttacacttgg attatgaaat aaaaagagta
    57421 attctaaagg ttgtaaatac tatgctgact ttgatacttc aaagtttagg tgattttgta
    57481 attgttaata gaaatacgtt taatgagcat aaagaattta tctaataata ggagaatata
    57541 atgtatacaa ttggacaagt atctaaattt ttaggaatat ctagagatac actaaaattt
    57601 tatgaagaca aaggattagt aaatcctaag aaaaatgatg aaaatggata tagaatatat
    57661 aatcaggttg atatctatga tattgcaaca ataaactttt atagagaaat tgatatagaa
    57721 attaaaaaga ttcaagaaat aagaaaaagt aaaagtataa acaatttaga actcttacta
    57781 gaagagaagg aacaaatcat actaaaagag atagaatata aaaagcttct cttaaaaaag
    57841 gttcagttag tcaaagaaga ttgtgacaaa atcaaaacat attttggaaa atacacaata
    57901 aaagaaatga agcctttgga agtaaaaggt aaaataaaac atgttactaa ctatgaggaa
    57961 tatgaagcct taaaagagaa tacaaacaac ttaaaaaaag cagttacatt aactgattta
    58021 agaagagtaa taaattttaa tgaagaaggt ataatagaag aaaaatttat aattgtaagg
    58081 gaagtagatg actacaacaa aatcatagaa ggtgaagttc tatctcatcc caattgtatt
    58141 tatactatta ttgaagatgg cagatggtca actggaggag aaaatattga taataaagtg
    58201 gaagacagat taagagaaat agcaatagaa aatgaatgtg aattacttgg aatagtctat
    58261 gttaatatat tgcttactac ttatgaagaa gggattgagc gtatattttt agagatttat
    58321 gcacctataa aataatataa aagcattgac ctgggactta ctcataggtt taaactcatg
    58381 atataagcag ttataactta tatagcaatt aaatattaat ttgaaatgag gattacttat
    58441 gagaacagag aaatcattaa aaaggcctat agccagtttt attattctaa caaatataat
    58501 ttttttacca ctttttttat tggtagtagt gactataatg ttaaaacttc caacagtgat
    58561 atctgacatt gcgttgtgta tatcagcgtg gtcatccact tttgcattta tgatattatt
    58621 taaaaaaatt tatccaggta agaaattttt agtacatgta aaagatagat ttagaaataa
    58681 acttaaattt tcaacagtat ctataataat tagtatacaa gtcctaatag ctgtagtagt
    58741 tatatttata ttagcatcta aaaatcatgg aataatgcct aactttacag tttcatcatg
    58801 gggagcattt atatatttat ttttaaaaaa tttatttgca ggatcattag gtgaggaatt
    58861 aggttggaga ggatttgttc aaaatcatct tcagaaaaga cattctcctt taaaagcatc
    58921 cataacagta ggtttttggt gggggatgtg gcatttacca atatggttta caacaggatt
    58981 caaaggactt gatttaataa aatatattat attttttatg attgcaatta tatcaatcag
    59041 tattataatg acaacttttt ataatctaaa taaaactttg ataataccta ttgcaataca
    59101 tcaactattt aattttttaa tagggataat taatgaagat ttaatagagc ttataaatta
    59161 ctatgcaatg ttatatttaa tatttgcaat tgcattaata gttataaatc caggaaatgt
    59221 attatataaa aatattagag agtaatatat atctttatgg taagatataa agatattatt
    59281 agaagaacat ccaaggagga ataaacatgg ttttactgat tgttgatgca caaaagttaa
    59341 taacaaacga gaggttatat aaatttaatg aatttgtagt aaatgtagaa aatttaattg
    59401 atacagctag aaaaaataat atagaagtaa tatatgtacg tcatgatgat ggagttgaaa
    59461 atgaattgac taaaggtaaa aatggctttg aaatatacga aaaatttaaa ccatgtaatg
    59521 gagaaaaaat atttgataaa aaagtaaata gtgcttttaa agaaactggt ctattagaat
    59581 acctaacaaa taatggtgaa aaagatatta ttattgctgg tctccaaaca gattattgta
    59641 ttgatgccac tataaaatgt ggatttgaac atggatttaa tataatagtt ccagcttatt
    59701 caaatacaac tgttgacaat ttttttatgt cagcagaaca atcatataaa tactacaatg
    59761 aatttatatg gaatgaaaga tatgcgaagt gtatttcatt agaggaaaca cttagaaaaa
    59821 tgaaataaaa atagagtatg aattgtatat gtacataagt tgatttcata aaaaaggatg
    59881 ttaaattcca agttaaaaat tagattaaat atattatatt atagataagg cacatcaatt
    59941 ttattttaaa ttaatgtgct ttttaattgt agtaatttat ttataatcaa tatgattttt
    60001 attatttaaa tcaatttttc ttgagtttct ttgtctaaag aaactttttt tatttataaa
    60061 atctacagtt atattatagt atctatttta gatgagttta atttttgtat caatctaaaa
    60121 caaaagttat acttaaatga aattgaaaac gataaaattc tcaaataaaa taagtattgt
    60181 ggaggtgatg aaagaatcca atgataatat gaagactaat cttaataaga aagtaggggt
    60241 taatggtagt ggacaaagaa attgtatcaa ttctccagat tttattaaat agcacattga
    60301 ttacaactaa tggattacaa gaggagtcta attcatcaaa gagacaaatt acttatagaa
    60361 taaataaaat caatgacatg cttaaagtaa aaaatgtacc acttatatgt ttaagagccg
    60421 acaaagatat tatcgttaga aaagaaacaa aaaaagcaat taaagaaatt ttagaaaaaa
    60481 actattctaa gaatacttat tattttagta agacagaaag acttttatat atgtatttaa
    60541 tgctttttat taacatggag gatatttcaa ttaatcattt tataaattct ataaaagtaa
    60601 gtaggtctac tgtaaatctt gatttcaagg atttgatacc agagcttgaa aagaagaaca
    60661 ttaaagttaa gaacaatcgt ataaatggat attacatagt tggcaatgag atggaaatta
    60721 ggagagtact tattaaaaac attatagaaa ctttgtctaa tgagaaaagt tcaagagtat
    60781 ttgatatttt tattaaagaa tataatttag atagttttga agaggctaaa aaaattatat
    60841 taaagctaat aaaaaaatat gaaattactt ttgttgaaga tagattaata gaatttatat
    60901 atatatttat ctttctaaaa gcaaggatgt attcaactag aatagttact caggaaaatg
    60961 tagatattcc taatatttca gttatgagtt caatgaagga gtataaattt gctaaggaat
    61021 tattagaagt atatgggagt gaagataaga taaagcctca caatataatg tatattagtg
    61081 cttggatttt aggtatatca gtaggaaatt atgaagaaga tacagaagat aaggatgtaa
    61141 tttcaaaaat tgtaaataaa atgatgacaa agtttggata tttaagcgga gtttactata
    61201 taagccaaga aaaaatattt aaacaattat attctcattt tagacctgcc tactatagac
    61261 ttttatttaa attacctatc tataatccga tttgtgaaaa agtaaaagaa gaatataaat
    61321 tagtttatag aattgtaagt aatgcaatga aagagttttg cggattattt ggagaagaaa
    61381 ttcaggaaga agagttagca tatcttacaa tgcactttgc aacacttttt tcaaataaaa
    61441 aagaatttga tggttttaga aaaagaatag cattaatagt ttgttcaaat ggcgttggta
    61501 gttcagctat tttacatgca gaacttacaa acttatttcc tgacttacac tttataccaa
    61561 tgtcggaatc agttggatta gaaaatataa gtgaacctgt agatattgta tttactacta
    61621 attataacgc agagggttta aaaacagatg taccagtaat taaagtaagc cctgttatga
    61681 ccacaaaaga aaaatataag attacacgtg aagtgtatat tcaattaggt gatatttttt
    61741 taagacaacc taaaatagat gaggttatgg atataataaa aaaatatgca aatgtaacct
    61801 ctgaaagtat tctttcaagt gagctattag cttattttac acagatagag aattttacat
    61861 ctaaggaagg agaggggcct atgctaagtg agattactaa tgaaacacta gtaaaaataa
    61921 aggtaaaagc taagaattgg gaggaagcta ttagacagtc agcttctgta ttagttgaaa
    61981 ataacaaagt aactgaaggg tatgtagatg ctatgattaa ctcagcaaaa gcatctggac
    62041 catacatagt aattacaaaa catgttgcac ttccacatgc tagaccagaa gctgggtcaa
    62101 aagagattgc aataggcatt gctactttag atagtcctat tgagtttggg aataacgaaa
    62161 acgaccctgt aaaatatgta ttttgtctaa gtgcaataga caataatagc catttacgtg
    62221 ctatgtctga gctagttgaa ctattggaag aagatgagtt ttttaaggtt ttagatagtg
    62281 ctaaagaagc taaagaaatt attgatttta taaaaacaca cgaattataa aggaggattt
    62341 aattatgtat aaaattttaa tcgcatgtag agcaggagtt ggctcaagtt taatgttaaa
    62401 aataaagact caacaaatta ttaaggaaaa taactttcca attgaagtag agcatggttc
    62461 attggattca ctaaatggat tcaatggaga tgctgtagaa acattaattg atgttgctga
    62521 agaattaaaa aataaaaatt tgaagtttga tataattggg attcacaata ttgttgaccg
    62581 taatgaaata aagacagcac tagaaaaatt ccttgcttca aaagagggat aaatttaaga
    62641 tgataaggag gaatatttat ggagtttatt attagtttgc tgagtacacc tgctgttttg
    62701 cttggcgtag ttgcatgtat aggattgatt cttcaaaaga aatcagctgt tgaagtattt
    62761 acaggctctt caaaaacact tatcggtttt ttgatatttg gtattggtgc ctctgctatg
    62821 acaggagcac ttcaaaattt caataaactg ttccaacatg gctttggaat tactggtgtt
    62881 atagcttcac cagaagcagc tacagcactt gcacaaggta catatggttt tgcagtttca
    62941 tgtacattaa ttcttggatt catattaaat ttagtatttg cacgtattac aaagtttaag
    63001 aatattttct ttacaacagg tcatagtttg ttcttttctt gtgtattagt tttaattatg
    63061 aaagcacatg gatttgataa tacaatcact attttaatag gtggaactat cttagggttt
    63121 atgtctgctg cactacctca attctgtcaa ccatttatgc gtgaattaac aggtggcgac
    63181 gaacaagcta ttggtcactt taacatgatt ggttatggtt tatcaggtta tattgggcgt
    63241 ttattttcaa aacataaaga tgatacaaca gagactatag aatttcctaa gtggttatca
    63301 atattcagag acttcttaat gggtctatcc atagttatgt taatcttatt ttatattgca
    63361 acattaaaag ctggtcaagc atttactcaa gaaattgctg gttcaacaca ttggttggtt
    63421 tttccgctta tagaggcatt tacatttgtg gcaggtatgt caatattgat gtcaggtgtt
    63481 cgtatgttct tagctgaaat aactgcagca tttgtaatca tttcagaaaa gtatattcca
    63541 ggttcacgtc ctgcgctaga tgttccaaca gtattcccat atgcaccaaa tgcagttatt
    63601 attgggttta tatcagcata tgctgctggt ctattagcaa ttgctattat ggcatcattt
    63661 cctagtatat ttcctgtagt aattattcca gctgctcaca tatgtttctt ctcaggaggt
    63721 acagctgcaa tatttggcaa tacttcagga ggatggagag gggctattgc tgggtcattt
    63781 gttgtggggt tattacttgc atttttacca gttatactat atccagttta tggcactctt
    63841 ggtatagaag gagcaacttt ccctaatatt gattacaatg tagttggttc gatattacat
    63901 aatattttac aatttataaa acctatttaa actaaattat ataaaagtat agtcatagtt
    63961 actatgattt caaggaggat acatcttatg gaaaatacat tatctgaatt tttagataat
    64021 atatctaatg aattgtcaga atttattgcc tcaatagatg agacatctat aaataaagca
    64081 tgcgaattaa ttcttgaagc tgaaaaaaat cacggacgtg tacatgtgac tggtattggc
    64141 aaaccaggac atgtatcggg atatatttca tcattgcttt catctactgg aacgtcagca
    64201 tatatattgc atggtacaga agcagtacat gggtcaagtg gtcaagtagt tgaaggagat
    64261 gttgttattg caatatcaaa tagtggtgaa actcaagagt taaaagcaac tcttaagact
    64321 ctaaaagtaa atggagcaaa gataattggt gtaagtggta atgagagttc atttttaaaa
    64381 aatatttctg atatattcct gtttgcaggt gttaaacagg aaggagattg tcttaataaa
    64441 gctcctcgtg cttcaatttt agctgaaaca ataatattac aatcattaag tgttgtatta
    64501 caatatgcta aaggtcttaa tacacagcag tatttgaagt ggcatccagc aggaagtctt
    64561 ggaaagtcta ttagagaggg aatataattt tatgaaatat aaagggatta tatgtgcaat
    64621 gataacacca tttgatgaaa atcaaaatat taattcacaa gcaacatgtc aattaattga
    64681 ttatttgatt gaaaagggaa tttatggatt atttattttg ggcactaatg gtgaatgtca
    64741 tgtattaaca gatgatgaaa aagttgaatt tgcaaagatt gttattaatc atacaaataa
    64801 tcgtgtacct gtttttgttg gaacaggggg taattcaact cgtgaagttg tagatttatc
    64861 taagagaatg gaagcgattg gagcaagtgc attatctatt attacaccat actttgttac
    64921 accaacacaa caggaattaa tcttacatta caaaactatt gctaattcag ttaatttacc
    64981 tattataatg tataatatgc caagtaagac tggaattaat attgaaccag agtcagtacg
    65041 tgaattatca aagataaaga atattgttgg aattaaggat agtagtggta aacttgacaa
    65101 catgaaagct tatattgaag caacgaagaa tgagaatttt agtgtgtttt caggctcaga
    65161 ttcacttatt ctggatagtc taaaagctgg tagtcaagga gctgttgcag caacaacaaa
    65221 cttcctcaca gagattggta tctctatcta tgaaaacttt atgaaagggg atttggaaga
    65281 agctcaaaaa gctcaaagta gtatagaaga acttcgacgt atactgaaac ttggaacaat
    65341 tccatctgtt atgaagaaaa ctattgtctt gaatggaatt aatgttggaa ctgcacgact
    65401 tcctgtaact gaaccaactg gggaagtact tgaagaaatt aaacgagtag ttgaaaatta
    65461 taggacaata cttaataaaa gtagtgagaa tagataatat aaatagggaa attacactgg
    65521 tatataatta atatatatat tataaaacat gactaaaatt aatgaataag taaagtggtt
    65581 tgatgagtat agaggtgata atatgaaaaa gatgaatata accaaaagaa tgtcagaatg
    65641 tggggctctt gcaattgtaa gagaagaaaa tcttaaccgt gcatgtgaaa ttgctgaagg
    65701 atgtataaaa ggtggtataa cagttataga aatgagttat accctaaata atgctggaga
    65761 aataattcaa gggcttaata aaaagtatgg tgaaacactt tgtgtgggag caggaacagt
    65821 tttggatagt gaaacagctc gtcatgctat attacatgga gctcaattta ttattgcacc
    65881 aaattacaat gaatgtgtag cgaagatttg caatagatat cagattcctt atgctccagg
    65941 atgtacatca ttgactgagg cagtagacgc actaagttta ggagcaactt ttataaaagc
    66001 tttcccaata tcagatttct atggacctaa actagtaaag gtatttaaga caccaatacc
    66061 tgatatgcca gttttagcaa gtggagggat taatattgaa aacctacata tatggttaga
    66121 aaatggagtt gatgtatgtg gatttggtgg tttattaact aaaggttctg ttgaagatat
    66181 tgctaaaaat gctaaaaaga ttcgtgaaat cattaaaaat ataagaaaaa tttaacatag
    66241 ggctgtatca tagtatctta taattactat gatacagcct ttttaatatt attcaaatta
    66301 aaaacagttt acatttctat tatattacat ataatttcag taattttatc ttaatttttc
    66361 tatctggaaa aaaatgattt aaaacttaag ttatgatata atttcattaa aagaaggcga
    66421 tttttagtaa atatgagaaa ataatgtgtt tttaggggaa aagttaaata cagatttaag
    66481 tgaacaagaa tcgataatta agatattaaa tggtgaatag ggcatcaaaa aaattactaa
    66541 attaaaagtt ttagagggag aatcttagca agtgtgtgtg aaaattcaat ttcaaacaaa
    66601 aaataattgt aaatgaaatc aatttataca cgttgaagat tcacttttat cattatatta
    66661 aaaagcagag tgaattaaaa gtgagtctaa agataggagg ataattaaaa caatgaaaga
    66721 agacattagg ttacatcgaa tgtgtaaaaa agaacaagca acaaagaatg aagttatatc
    66781 agaggatatt ctaaaatcta tgagtattgg ggtcagtaaa cattttttag atgattcatt
    66841 tacaataata tggggaaata catcattcta tcaattatta ggatatacag aagaagaatt
    66901 tttagttaaa ttttctagtt taaaagatta ttatgaacag aatctttatc attttgaatc
    66961 tatgaaaaat cattttttag aggcttatca tcatggcgaa aagagtatag aatatcaaat
    67021 ttgcatttca gcaaataatg gagaccctgt ttgggtaata atgactggta tattaattga
    67081 atcacaagat aatgagaaat caatggtcta tatattgtat tcaaaaatta atgagttaaa
    67141 aataaagcaa gaagaactat ctgatatgga aaaagagagt acagagaatt ttaaatggat
    67201 gatgtcagag tatgctggga atgtttatat tagcgatatg gatacatatg aattactata
    67261 cttaaataag cactcatgca atactttaca ggcatcagca aatgaactta ttggaagaaa
    67321 atgttatgag gtaattcaag gtagaacttc gccatgtccg ttttgtacaa attcgtattt
    67381 aaaaaaagat gacatatatg aatgggaatt ttataataaa aaactgaaac gaacatttat
    67441 aattaaagac cgtatgttga attggcaagg gcgaagagtt cgtattgaat tatcttatga
    67501 tatgtatagt gctgaatata aattagcaaa aaaagatcag gaaagagaat caattttgaa
    67561 aactattcca gcaggaatgg ttagattaga tgcaagagat tatcttacta tactttggtg
    67621 taatgatata tttttgaata tgattgaata tacaaaggaa cagtttgcag aggaacttaa
    67681 taatcaatgt ggatatttat tttctgaaga ttataaacgt agtaagaaac tggcacaaga
    67741 tttgaaggag tctggggata atgttgtatt tgaagcaaaa atatatacac gttcaaggga
    67801 agaacgtata tggactgtta cattgtgtta tatcagtggg gaagacagtt gggatggaat
    67861 accatctttt tatagtatag gtattgacat aacaaaggaa agaaaacaga ttgagaaatt
    67921 acagcatata tcagagaaag atgcattaac aggaatttat aatcgtgctg agactgaaag
    67981 gcagattaag aaatattttg aaaaaaattt aaatgttatg ggtgcactgt ttatgattga
    68041 tacagataat tttaaacaga ttaatgatac agaagggcat atgattggag atatagtact
    68101 tactgagatg gcatcaggta tgaaaaaaat aatgcgtgac agtgatgttg ttggaagaat
    68161 aggtggagat gagtttacaa tttttatgaa gaatatttcc tcagttaaag atgcagaaaa
    68221 gaaagcagaa gaactattgt atatgttccg tcatctattt cagaaagaaa aaagttttct
    68281 aaaagtaact tgtagcatag gaatagctat atatccaaag gatggtacta cattcaagga
    68341 aatatatgca agagctgata aagccctgta tcaagcaaaa aatatgggaa aaaataatta
    68401 tgtaatctac aaccaagatt attttaaaga attagaagaa tttgattgtt cttctcttgg
    68461 tacagttatt gattcagaaa aacaatacgc tgaatatcct gataatctta cacgttatat
    68521 attccgtatg ctttatcaga ctgatgatat agaccaggcg attaatatga tacttgaggt
    68581 tgttgggaaa cagtttgatg taagtcgtgt ttatattttt gaaaatacag aagatggtag
    68641 atatacttct aatacttatg aatggtgtaa tgaaggaatc tcttctcaaa tggcttattt
    68701 gcaaaacagc aattatcaag actatgagga ttatgaaaag ctttttgagg atgaattagt
    68761 tttttattgt cgagatatcc atacattaag tcctaaacta gaagaattgt tttctagtca
    68821 aggtatccac tctacacttc aatgtgcata taaagaagat agagttttca gtggatttgt
    68881 tggatttgat gaatgcacag gactacgtct atggtcacaa gaggaaataa gtacattatc
    68941 attgatttct caaattatat caatgttttt acaacgtaaa aaaaataata aacttaatca
    69001 acagattcaa caataccaga atattttaga taatattgac cagtgtattt gtgtgattaa
    69061 taaagaaaat aattttttat tatatgtaaa taaaaaattt aaaaatacat attctaaatt
    69121 ccaaattgga caaccttatt atcttgattc tatagatatt cataagatat ccattatatg
    69181 gaataaaaaa gaagcatacc tatgtactag cacgatttaa tggtaaagta aagtttatat
    69241 tggacttaaa ttaaatttcg ttttaaataa gatattattt tagttgctta ctgaaaagac
    69301 tagaatctat attaatgaat tatactaatt ttataccact attaaaatat tgtttgctaa
    69361 aaataaaaaa tagccttaaa acagttgatt ataaaaaatt aactgcttta aggctatttt
    69421 tatctttgtg acgaaataga cacttgccat ttagaatgtg acaatatagt agttgtttag
    69481 aaaaggcaca aagcattata ctttaactaa agtaaaatgt attttgcttt tagaataaaa
    69541 acaattagga gggagctata attgaaaaag ataatatatg tattatttac aattgaacta
    69601 ttaatagtat ctttattag
//
LOCUS       DAEPID010000012        64666 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.012, whole genome shotgun sequence.
ACCESSION   DAEPID010000012 DAEPID010000000
VERSION     DAEPID010000012.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 64666)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 64666)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..64666
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.012"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            112..948
                     /locus_tag="KR257_000892"
     CDS             112..948
                     /locus_tag="KR257_000892"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891338.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PRD domain-containing protein"
                     /protein_id="HBH0029615.1"
                     /translation="MNIKKIFNNNVVVSSLEDGTEIIVTGAGVGFKKKVGDLIDENLI
                     SKKYFVQDDQRDKYNQILNKTSIEYFKISEEIIEKANEVLNTQVNDSIILALTSHIEF
                     AVQREKQGIKLPNLILNETKQLYREEFEFGLWAIDEIEKRIGIKLPEDEAGYIAIHII
                     NGLENSQKDEGINILEFSKQVIQIIEEVHGFKLDVNSLNYTRLITHLKFFVQRILRKE
                     TYNDSDIEDMYKLVNKNYNKPKVCTEEIAALVLDRFEYKISKEEELYLMIHINKITNS
                     GC"
     gene            1301..2878
                     /locus_tag="KR257_000893"
     CDS             1301..2878
                     /locus_tag="KR257_000893"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003439882.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS transporter subunit EIIC"
                     /protein_id="HBH0029616.1"
                     /translation="MKKNKLGLWNFFQMLGKTFMFPIALLSVSGMMLGLGAGFTDPKM
                     IEMVPFLGNEYVNLVLNFMLTIGLFAFNNLGALFAMAIPLGLLKKEKEFGAFSGLVGF
                     IAMHIGTNFYLTRADLLVPAEQMSTNGQAMIMGIQTYNTSVLGGIVAGLIVYAIYDKV
                     SNLKIPESLGFYSGPRLVPIVSLIVMSIVGLLIPIVWPPFFNAFQSLGRWISSAGPLG
                     YFSYAVAERVTIPFGLNHLVTSVFRFTPIGGTAVIDGETYFGTLNMFMAYVENNQIIP
                     LDLAGKMEQGKLMIQYGLAGAALAIYRTAKPENRKALKGLLISGVLTVIIGGISEPIE
                     FLFLFISPALFAFHTFMNGIANMVLPYLGVLMGFTGDLIAFISFGVLRGTATGWPIAV
                     LVAVLYFAIYYFVFKWAIIKFNIKTPGREDKEIKVSEGNGSDFKNLSTYKGQQMISAL
                     GGQSNILSLDNCVTRLRLKLQDVSLINEDAIKEAGGIAVVKLDEHTIQVIIGTQVYSL
                     RKQMDKAMEGHLEACND"
     gene            2871..4055
                     /locus_tag="KR257_000894"
     CDS             2871..4055
                     /locus_tag="KR257_000894"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003439880.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PatB family C-S lyase"
                     /protein_id="HBH0029617.1"
                     /translation="MINFDKKVDRLGTYCTQWDYVEDRFGKKDLLPFTISDMDLEFPF
                     EITEVLQERLNHRVLGYSRWKHDDFRNSVTNWYIKRFNCSVDSNWIYYSPSVMYSISK
                     LIEMLSNEGDGILINTPAYNAFYDVIINNNRNIIKSHLVNRNGFYSIDFNDFEKKCKK
                     SKIFILCNPHNPTGRVWSELELVKMIGICKNNDVKIISDDIHMDIVYDNRMTPILNVA
                     KDYLDSVFICTSASKSFNIPALTGSYVIIPNEGIRNKFENITRYRDFVNSPAILAILA
                     TMVCYDDCEYWLDELLKYLKENLKYTIDYIKDNLEPLKLVMPEGCYFAWIDFSELKIS
                     GEKFQKLLMDIGEVAIMSGSVYGEEGEFYLRLNVACSREKLEDGLNRIKKTMDYIAKR
                     IL"
     gene            4073..4672
                     /locus_tag="KR257_000895"
     CDS             4073..4672
                     /locus_tag="KR257_000895"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903412.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SIS domain-containing protein"
                     /protein_id="HBH0029618.1"
                     /translation="MGYLKTMVDVMTTEMNAIRCLIDEAGIEYESIVSEIANCEGKVI
                     FMGVGKSAHIGKKLAATFASTGTPSFFVHATEAVHGDLGMIESKDITILISNSGNSME
                     VVNCIKYIKAIGSKTIAFTSNRNSVLAKECDYALIYPAKDEADHLNLAPTTSSTITLV
                     LGDSIACALSKSSNFGSSDFYKYHPGGSLGEKLKTANNG"
     gene            4696..5166
                     /locus_tag="KR257_000896"
     CDS             4696..5166
                     /locus_tag="KR257_000896"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003439878.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS glucose transporter subunit IIA"
                     /protein_id="HBH0029619.1"
                     /translation="MFKMFKKKSIKSPISGKVIELSKIQDGVFSQKIMGEGVAIDSTG
                     DIVYAPINGKIVVVAETKHAFVIELENGMELLIHVGLDTVNLKGEGFEVLVSMGEQVK
                     EGTPMLKINRPLIESKGISLITPVTITNHSEYNMNTCNVGNSVEGGKDTVIEFK"
     gene            5538..6284
                     /locus_tag="KR257_000897"
     CDS             5538..6284
                     /locus_tag="KR257_000897"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891335.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF2087 domain-containing protein"
                     /protein_id="HBH0029620.1"
                     /translation="MKIENLSIDDIKRGYIFNDDLNCYSCIKCTKTYEVGEIYKIGNR
                     FFEASKAIELHMELEHSDYLEQLLNSDSKYNTLTENQKQLFQLFISDLPDKEIAKQVG
                     VSTSTIRHQKFIFREKAKQAKLYLALYESVFEDKSNKSSTIIPIHEHARMVDERYVVT
                     EEERKHILDTSFESMNPLKLKVFSSKEKKKVVILSKILEQFERGKKYSEKEVNQILES
                     IYDDFATIRRYLIEYGFMSRNKECTKYWLT"
     gene            6345..7019
                     /locus_tag="KR257_000898"
     CDS             6345..7019
                     /locus_tag="KR257_000898"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861786.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="epoxyqueuosine reductase"
                     /protein_id="HBH0029621.1"
                     /translation="MNDELKSILYNKGVDIVRFVDISEFPINQTQGFSKAILFCIGLS
                     KKFITDIYNNLPTDSDEFLEKEEKVEELADWISKYIQNKGYRAYSQSEKNNLEHGYFE
                     KAYINPEMQSGISPLPHKTIANISGIGFMGKNNLFVTEEYGCAFSMCTVLTDAPISVE
                     RYPLIDSKCMDCNVCVENCPAKAIHGNEWTLPGKRESIIDVSKCFCVLRCMMSCPWSL
                     RYANQK"
     gene            7388..8734
                     /locus_tag="KR257_000899"
     CDS             7388..8734
                     /locus_tag="KR257_000899"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898101.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycoside hydrolase family 55 protein"
                     /protein_id="HBH0029622.1"
                     /translation="MEIETKTPDWINVLELNSKIDITGKYDVSNMIQNIVSDKSLEGS
                     IIYFPKGNYLFEKGIKISQQITLQGDSYYGGGNQVSNLDKKQSIIGTTNFITRGVSNM
                     SIITLSGTSQCIKNINFYYDSHDIEKIPPKNVSAITEYGETQGLSHFEHLFISGFSGI
                     GIEIPYYSTGNDITVSSCGLGMRLGEKSMLSSSKIYECKNGMEITTGVSLNNVRIEEI
                     KEIGINNKGFGFNLIMNLMVDQCGYCGFMFEKMCYSQITARITRCGQYYKSVDYNAYE
                     NMEDRKEEAYSIFYGDILENCNIVLMNSNIDTLENDSLDEHKIYVIKANETNNVMLTC
                     YAEADNFIQCAKGNLLLENGENTYKFYNGEICSVGGVQISDIDEKDLIKIIENTLYID
                     DKGKYLMVPRLKKNTVIYSVLDSTEEINKLHGGIWEQIDVKVLAGESMYYYKKIKD"
     gene            8761..10161
                     /locus_tag="KR257_000900"
     CDS             8761..10161
                     /locus_tag="KR257_000900"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903406.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0029623.1"
                     /translation="MEESIIIKDISGWINVLDYGICNDETKDVSFKLQEIMDAVPEDS
                     IIYFPKGKYLFESGVKIKKRLTLCGDSYILANVPKNTAGVTQFTFKGKKNPKSENIAI
                     ITAKSVRHCIKSICFYSDSCDRDMTSNHEPPTDGKPRFHHNVIINYRNISAIVCEDKQ
                     GESGHYKNLSFSGFSGIALDMPNNSTANDITIFTSGLGISTGENSTIANSKVWGCVDG
                     MIISTGTFINGMRVEEIKKVGIKNIGRGLNFITNITIDQCGYCGVWFDSISNVQISGN
                     ITRCGQYYYDVSYDNYLMLDNRVKEAYSLFYGNLLESSNIVLSNTNKDNWEDFKEDKH
                     KVYLVEALETKNVLLTCNIDATDWIVKSEKGNLTYNNMRQTVIFYDGKLSSINGIGIS
                     DEDYGDKVKIKKGNIYINSKDKDIKMHKPEVGDIMSTIIKDKSILSAHYGGTWEKIGE
                     KIEFGITVHYYKLIEK"
     gene            10371..11807
                     /locus_tag="KR257_000901"
     CDS             10371..11807
                     /locus_tag="KR257_000901"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898097.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycoside hydrolase family 55 protein"
                     /protein_id="HBH0029624.1"
                     /translation="MEGRTGIKDGRWINVVERGIKNDGSYNVGPALQDIIDEIETDFC
                     VLYFPKGKYLFTSGVKINKEIVLQGDSNSSTGTTQFITRGVENMSIITLTGKKQCIKN
                     INFYSDSCEIQVNKEPPTKGNPKYHYEMIINKNEKNVEMNNVSAILYDNSKNMIKGLG
                     HYENIYISGFSGTGIRIPYYSIVNDITVSSCGLGIDTGIDTIISNSRISKCQNGMRIR
                     TGTSINNVRIEKIQKVGLISSQVKGYEGYGSYKINNITIDQCGYCGFSFDSMKDSYFS
                     GIIRRCGQYYYNTDYDTYLSIKDRVEEAYSLFYGNYFTECNIDLVSDNKDNWDDGLEY
                     KHKVYVFKTLQIPKLTLRCNIDAYDYIVKSVHGGGNLMLKNNFNNYIFIDSSNPEVIN
                     GINFNYQKNGNLLRLNNGKLSYKNGKEETAIFRPNYGLIVASTDSECEQIETSYGGKW
                     EKLGSEVIGEETVYYYKHHEPDKTNQIQ"
     gene            12151..13095
                     /locus_tag="KR257_000902"
     CDS             12151..13095
                     /locus_tag="KR257_000902"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728993.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1848 domain-containing protein"
                     /protein_id="HBH0029625.1"
                     /translation="MIVSVSRRTDIPAFYSKWFFNRLKEGFVYVINPMNPKQVSKIEL
                     NPHTVDCFVFWTKDVTPMLYDLNKLKDYKYYFHYTITSYGKEVETCILDKRKVIDSFK
                     ELSRKIGKERVILRYDPIFLSEKYTVDYHIKAFASLCNQLDGFTEKCIISFIDLYKKT
                     KFNTKALHIKPIEITEIETLSKEISKIAHKHGITLEMCSEEYNLSKFGIGKSKCIDDR
                     LISKIIGCEVEVKKDSTQRDICGCVKSVDIGQYNTCRHYCLYCYANFNYAKVEENCRL
                     YKEDNKLLIDTLRDDAKISIRDMKTIKVDKNKQISIFD"
     gene            13264..14196
                     /locus_tag="KR257_000903"
     CDS             13264..14196
                     /locus_tag="KR257_000903"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018112805.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TDT family transporter"
                     /protein_id="HBH0029626.1"
                     /translation="MNLLKKYPIPIASLILSIFTLGNLLQSYSESLRNVIGFIGFILY
                     AIYIVKIILLRKGVKEQLENTLISSTFPTITMATMIFATYIKPLSLELSIMIWSIGIV
                     GHLVLIVLFSKKFLVKFSIKTVFPSWYIVYVGIVAASVTAPAFNQLLIGKIAFWIGFV
                     SYIVLIPVILKRVWIIKEMPEPSLPSIAILAAPGSLLLSGYINSFSDKNNVVLYLLFI
                     LSIVFYIIVLGYLPKLLRLPFYPSFAAFTFPMAISAMGMKLMNGYLTKSGHFISWISY
                     ASKLEEIIATVIILYVLVLFIIYLSKSETTSKAK"
     gene            14301..14768
                     /locus_tag="KR257_000904"
     CDS             14301..14768
                     /locus_tag="KR257_000904"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003431999.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="C_GCAxxG_C_C family protein"
                     /protein_id="HBH0029627.1"
                     /translation="MKTKEEYLKEVRNISEEYFRKGEFFCSEAVLQTINDALGQPLSP
                     EITKLASGFPIGLGKAQCLCGAISGGEMALGIVYGRVHGEAMNPKMFEHAKGLHDYIK
                     KEYGATCCRAITKKWDGDNFMSPERKEHCIKITGQVTEWVADKLIEDEKLNIK"
     gene            complement(15012..15866)
                     /locus_tag="KR257_000905"
     CDS             complement(15012..15866)
                     /locus_tag="KR257_000905"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009912760.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glucose uptake protein"
                     /protein_id="HBH0029628.1"
                     /translation="MLTIIIALLPVMGWGLMPIVANLKKSSPHEQLLGTSISAFIFST
                     IITLVIHPEITFFSFCISMISGIFWSLGQLMQFKAIQIASVSKVMPISNGSQLTFTTL
                     LAVILFNEWTSSKMLLIGSLSILCIILGILLTNYQTKKSTDKNMLKCVGVVLLSSLFL
                     SLYVVTNQIFLIEGYRIILPQSVGMLITSSIIVKYFSKEIVYRENVLFNLITGILWSI
                     ANLGMFITTNTLGVTISFSISQSCVIVATLGGIIFFKEKKNKKEWLAIFIGIILIMSG
                     VFMLSIIK"
     gene            16032..17996
                     /locus_tag="KR257_000906"
     CDS             16032..17996
                     /locus_tag="KR257_000906"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018112804.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcription antiterminator"
                     /protein_id="HBH0029629.1"
                     /translation="MLTDMIQNREIKIIKFLLKEGHTTVKAIADDLDVSEKTVSKSLK
                     EVEAVLKKIGLSLIRKPKIGVYIDGDLKKILPYLDNKGSQIPTTREERVIYIYSVLLK
                     SNDYITIQQLSDELYISRGTIERDLAEVEKLLKNEGISIYKKPSKGIKLNISERDKRQ
                     LTAKFIHKFWSRNWYIKQEQESFYQAFEKIQADVNGIFSEDDLSIIIDILRNFSRERK
                     FEFSDYEFQSLVIHLAIAVERIRKGEYIEESLYTGNIENNQMSNTNYLAKQLEEKFSI
                     LLPKSEIGYINLHLVASDQHRDTNELKNTSTNPCETSTNNISNLREIIKNTLYETAYD
                     KDLIDGLTSHVHSSINRLKYGLSIKNPYVNTIKQNFSLSFEQALDLKKVIEFIYDIRI
                     NDDECAYIALHFEAFRERMKELPQNIRVILVCSTGLGSSRLLSARIKKYFPMIKIEKV
                     LSVQELVSSKIDADLVISTIYLELETIPTIVVSPILNESDIRTLERNIQNVSSCTSKK
                     YKSFRNLIFEENILLNIEASNYEDAIKYITDNLIKKGFAKEGIAKSAIERENLSYTSF
                     QSIATPHANPSYIKKSNISVATLKNPITWGNEKVEVIFFISLENDKNLELDEIYEVFY
                     DFIDNKKNINDILSATSTKEVYDLLVEESI"
     gene            17996..18457
                     /locus_tag="KR257_000907"
     CDS             17996..18457
                     /locus_tag="KR257_000907"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422574.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIA"
                     /protein_id="HBH0029630.1"
                     /translation="MKISDVLKKEQIVFNLDTNTKEETIKKLSSIFVENGIVDNEEEY
                     VKSVLEREEHSTTGIGNGIAIPHGKSNAVKKSSIIFAKTKHKIEWDALDEKPVDSIFL
                     LAISNIDKDSNHLVLLSKLATKLMDDDNVDALKLANSEQEIINIFSEEGEM"
     gene            18460..18780
                     /locus_tag="KR257_000908"
     CDS             18460..18780
                     /locus_tag="KR257_000908"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_463956.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS fructose transporter subunit IIB"
                     /protein_id="HBH0029631.1"
                     /translation="MKRKIIAVTACATGVAHTYMAAQALKKASKKMGHLIKVETQGAT
                     GIDNELTTKDAQIAEVVIFAVDTKVRNAERFEGKEILEVPVNAPIKDAEKVINDALKL
                     IDTK"
     gene            18796..19896
                     /locus_tag="KR257_000909"
     CDS             18796..19896
                     /locus_tag="KR257_000909"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891322.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS fructose transporter subunit IIC"
                     /protein_id="HBH0029632.1"
                     /translation="MLKKIVSELKKHVLTGISYMIPLVIAGAMIMAISRVGGSFYNIP
                     DIWDAKYAESASSIVRLLHDLDGFGGTALGLMFPVIAAFIGFSIADKLAIVPGLVGGM
                     IAKDIGAGFLGALAVGLIAGYTCLFIKNHVKLPKSAASIVPIFIVPVFGTLITVVLIN
                     YVIGIPFATLNTGLENWLNGLSGTNQILMAAIIGAMMAVDLGGPVNKAALTTSLALLT
                     SGIYAPNTAAMVGIVIPPLGLGLATILAKQKYNKQLREAGKSSLIMGLIGVSEGAIPF
                     AVESPLKVIPSCVIGTAIASAMAVGLGSVNATPISGFYGWFTVENWPMYVLSIAVGTV
                     IVAGLVIVLRGNPVIEDDEFEDDDFDEAEWES"
     gene            20016..22616
                     /locus_tag="KR257_000910"
     CDS             20016..22616
                     /locus_tag="KR257_000910"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903397.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha-mannosidase"
                     /protein_id="HBH0029633.1"
                     /translation="MIKAHIVNHTHWDREWYFTSGDALVLSEQLFTDVIDELERNPDV
                     SFVLDGQLSILDDYVQLHKEKIEIIKKLIKEDRLHIGPWFTQTDAFFARGESILRNLM
                     IGIFESKKYGKYMKIGYLPDTFGFNAQMPILLKHVGLDNIFFWRGIHLGKQVQSPYFK
                     WKSLNGESYIYAVNMPHGYGTGMLLEPSLKYVNGRLDPAIDFIKSYTDVDEVLIPSGN
                     DQLNIIGDFKNKIKAINDIGKYSYITSSYQEFLKYIKSIESLESYRGEFREPVLARIH
                     KSIGSSRMDIKLACDKLENKLIKRIEPLLVIAKKSKIEISNQLLINTWKKLLEGQAHD
                     SLAGCVTDTVTDDILHRIREANEICDSIENTIVKKISEGLKLSKNDILVFNTEAKRFN
                     GYKEIQVVSDSKNIYFKDNLDATIIEETYVKPRENVLEETPAGNIFIEEPGYYILKVR
                     INVQLPALGYKVVSFELSDKEMVSLDKSNDTFISNDNYKIIYEDGSLNLQLKDGTYIS
                     NFLTLKDSGNAGDTYDFSPLKNDENIKLSFDKVYTEKALGYEKMVVKGTTLLPLTLED
                     RKNKYLNGKLNVKVSIVLSKENPLMDVKLCVDNTIYNHRLRVHIKTDIKDNKNIASLP
                     FGYITRKNGVLDNWEDIYSEMPIDLEPLESNITLTNQNRSCTVFTRGIKEYQHIEDEI
                     ALTLLATTDELGKPDLLYRPGRASGDTTKKGHIRIKTDKAQMLKELEFSFAIYMDSKS
                     FDELEIANLTHNYLRECVNYQLQDYNFFLYHIDNKIQKSIVNKTVSRELEIISLPENY
                     LISACYPSYYSKDKFIIRVENPSSNRMILDEQIFKNRNGKIVNAIEDVEEEQVYEIAP
                     FDVISILLDL"
     gene            23085..23420
                     /locus_tag="KR257_000911"
     CDS             23085..23420
                     /locus_tag="KR257_000911"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004453818.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HBH0029634.1"
                     /translation="MYNIDDMIYNCPVEALSNILGKKWVAIIIWKIQEDKKRFGELQR
                     AIPDCSKKMLVQQLDFLIEQGIIVNQKKLVNNVVESTYFLSESGLRLLPVMEKMIMWS
                     NKNLNCDKY"
     gene            23557..24834
                     /locus_tag="KR257_000912"
     CDS             23557..24834
                     /locus_tag="KR257_000912"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891317.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="redoxin family protein"
                     /protein_id="HBH0029635.1"
                     /translation="MQNVNLFLVFIEGIVSFFSPCILPILPIYLSILSNSSVENLKEG
                     KTSFIGSSLFKNTIFFALGISTTFFILGSSVKVLSMFFNENKDLIMFIGGIIIIIMGL
                     FYMGIIKSSILNREKRFNVKFKEMKAITAFILGFTFSFGWTPCIGPILASVLVMVSSS
                     SNHLSANLLIAVYTIGFILPFIITAMFYSKLFKTIDKIKSNMEIIKKIGGIILIVSGI
                     LMMVNGFGSISKHFNTSQNSKIESKQEENKRENSTDKEENSDGNDSQKDSNNDNNDKG
                     SNDEDRIKSIDFTLTDQYGKTHKLSDYEGKVVFLNFWATWCPPCKEEMPYIEQLYKDY
                     NKNNDDVVILGVASPNLGREGSREHVVNFLKEQGYTFPVVLDEDGALAYQYGINAFPT
                     TFIIDKEGYVTQYIPGAMDKATMASFIENQRNK"
     gene            24955..26343
                     /locus_tag="KR257_000913"
     CDS             24955..26343
                     /locus_tag="KR257_000913"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422581.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NAD(P)/FAD-dependent oxidoreductase"
                     /protein_id="HBH0029636.1"
                     /translation="MKKTFDAIIIGFGKGGKTLAGDLANRGLKVALIEKSNKMYGGTC
                     VNVACIPTKSLENSANSVKTKNINSWDEVQAEYEKAIDKKETLITKLREANYNKLNSN
                     ENVTIFTGMGTFIDEKTVQVKTENEIYELVADNIFINTGSRPFIPNIKGIENKNIVYD
                     SESLMNLRVLPKKMTIIGAGFIGLEFAGIYSSFGAEVTILNSNNGILPNEDVEDSEEI
                     IKLLAKRNVKIVNNANIKEIKEVSELAIVEYEVDGKSKELTSNMILVATGRKANTEGL
                     GLENAGIELNERGFIKVSETLKTNKEHIWAIGDINGGPQFTYISLDDYRIVINQLFGD
                     KTRTTNDRKNIPNSIFISPAFSRVGLNVKQAKEKGYEVLVAKMPVEAIPRAKQIGKAD
                     GFIKIVIDKKSNKILGASMICENSSEIIHLIQLAVDLEVEYTYLRDRVYAHPTMTEAL
                     NDILSPNMIKEV"
     gene            26547..27260
                     /locus_tag="KR257_000914"
     CDS             26547..27260
                     /locus_tag="KR257_000914"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017208807.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF434 domain-containing protein"
                     /protein_id="HBH0029637.1"
                     /translation="MNKISKRGFDDSDKRWFSSKELTRLIKAKEEIEWLLNRDYKIDP
                     VVTFVGDRYQFSIRQRDALKRAVCTDEKNIIRQSKRLSLDKIKEDTVNIDGFNLIISI
                     EVGLSGGTLVIGSDGNIRDLAGLRGTYKIIDKTEEALNLIGKFFNKYNAQNLKFYLDA
                     PVSNSGNLKYRILEHAKTWGIETEVELVKNADVVLEKLDRVVSSDAVIVDKCISYFNV
                     ARGIIEEYIKECNIINLNK"
     gene            27378..28247
                     /locus_tag="KR257_000915"
     CDS             27378..28247
                     /locus_tag="KR257_000915"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422583.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SH3 domain-containing protein"
                     /protein_id="HBH0029638.1"
                     /translation="MRGWICVKLTKLNIKKYRAPIYKYALANINLRSAKSTNSSIITV
                     IPQGAKMEVLDEEDDWIKVMYNSQEGYVYKELVSVSEYAWSNLNLREDKSTTSNIITV
                     IPEKSRVEVLQVDGDWSKVVYDDKIGYVFNYFLSIDGNKPNELDYKYFYTDMIKFVNE
                     NNIKSTSDYLIVTDLRNKYTYIFKKDNGGWGQLYKWQCTIGKPETPTITGIFYISGRK
                     PSFGTDEYSVKYATRIKGGYYYHSVLYDSTGSYIIDGRLGEALSHGCIRLSTENAKWI
                     YDNIPDTTTVIIH"
     gene            complement(28402..29547)
                     /locus_tag="KR257_000916"
     CDS             complement(28402..29547)
                     /locus_tag="KR257_000916"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903393.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="iron-containing alcohol dehydrogenase"
                     /protein_id="HBH0029639.1"
                     /translation="MSIYYVPPINLLGKGCLNEAKDSIKSLGTKKAFIVSDKFLVSNG
                     TVKKVTDILSQIDIDFVVYDEVKQNPTVTNVNKGLKILKSENCDFVITIGGGSPQDCG
                     KAISILATNGGDIRDYEGINKTSKKCLPIIAITTTAGTSAEVTINYVITDEDRHVKMI
                     MVDTNSLATMTVNDPELMISKPSNLTAATGMDALTHAIEAVVANGAYDVTDSTALYAI
                     KQIFKYLPRAVKNGNDIEAREQMCYACFLNGIAFSNAGLGNVHAMAHQLGGLYDLPHG
                     VCNAMLLPIVEEENAKSAPAKFRPIAEVIGMDVNNKSDKECVDFVIDKIKALSEEVGI
                     PKSLKDVGVDNPNFELLAENSMKDACAGANPVFFDKDKIIELFMKIS"
     gene            complement(29880..30656)
                     /locus_tag="KR257_000917"
     CDS             complement(29880..30656)
                     /locus_tag="KR257_000917"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422585.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IclR family transcriptional regulator"
                     /protein_id="HBH0029640.1"
                     /translation="MTSDNHRPTARILDILEALAESENGYTLTEIADVINAPKSSIFP
                     IVHTLNARKYITIDKNTSKYSIGIRSYTLGSSFFEKRTIFNYIIDEMTNIVNSCSETC
                     QLGILDNNEVLYIGKVDSPEPIRLISYVGKKIPANCTGLGKALLCDFDKEKLISLYPD
                     GLKGFTEKSITDFDVLYDQLLEVQRTQIASECEESMEHLKCLAVPIRKNGCIRAAVSV
                     TLPLFRANDEKIELIKKLLLNAQKNIQSMMEERNEDIVIN"
     gene            31238..32212
                     /locus_tag="KR257_000918"
     CDS             31238..32212
                     /locus_tag="KR257_000918"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422586.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="2-keto-3-deoxygluconate permease"
                     /protein_id="HBH0029641.1"
                     /translation="MIMDFIKKIPAGMMIVPMFIAAFINTFCPDIVQIGSFTTAVFSS
                     VGSATIIGVQLVCLGTQLQFREMPKVLKRGGILLGSKFAIGALIGILIGKLFGMDGVL
                     GLTTLAVISAVTNSNGSIYLSLMTSYGDETDCATMSLLTLNDGPFFTLIALGTSGLAN
                     VPLLSLLAAIVPILVGMIIGNFDKKMKEFLEPGCNLLVPFVGFALGSSINLASILKGG
                     LSGVLLGLISVFVGGIFIVFCDKFIGKRPGYAGWAVATTAGNAIAVPAAVALVDPSWQ
                     PYVATATTQVAAAVVVTAILVPLITSWWAKKYGCPKFPKQNEDGTITA"
     gene            32310..32615
                     /locus_tag="KR257_000919"
     CDS             32310..32615
                     /locus_tag="KR257_000919"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422587.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="UxaA family hydrolase"
                     /protein_id="HBH0029642.1"
                     /translation="MINAVIIDEKDNVAVAIEAIAKGSEISFKLKDKTVKTITALDDI
                     TIYHKLAIKDMAKGDKVTKYGEHIGEANQEIKSGQHVHIHNVRSVREDLDKQVMTNI"
     gene            32771..33931
                     /locus_tag="KR257_000920"
     CDS             32771..33931
                     /locus_tag="KR257_000920"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003439842.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="UxaA family hydrolase"
                     /protein_id="HBH0029643.1"
                     /translation="MKFYGYKRPDGRVGIRNHILILPTSVCASDTTRIIASQVQGAVT
                     FNNQNGCSQVHSDQQLTMDVMAGYAANPNVYGVIVVSLGCENCQNDLVVDAIKERTNK
                     PIKTLVIQEEHGTLKTIEKAVRYAREMAQEASLLRKEEFPISELILGTECGGSDPTSG
                     LAANPLIGELSDKLVDLGATSILSETTEFIGAEHILARRAVNEEVKEKILHIVHRYEN
                     SLKLVGEEVREGNPSPGNIAGGLTSLEEKSLGCIHKGGHRQISEVYDYAKQIDKKGLV
                     IMDTPGNDASSVAGMVAGGAQIVVFSTGRGTPSGNPIAPVIKITGNKITFANMEDNMD
                     FDASPVIYGPQTMEELTDDLLNMVVDVANGKQSKAESLGYTEMAIARVCNYV"
     gene            33981..34883
                     /locus_tag="KR257_000921"
     CDS             33981..34883
                     /locus_tag="KR257_000921"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429073.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="fumarylacetoacetate hydrolase family protein"
                     /protein_id="HBH0029644.1"
                     /translation="MKFVSFTEGENECKRTGVFSKDELFIIDVNSLNLSRNFKDLNEL
                     IQNVSSEDIIKLKTIINESTFYNYDVFKRERCTVHVPIEKPIHDILCVGVNYKDHLEE
                     TQTHFDDSFEEPQKTVYFTKRVTKAIGPEDEIDGHFEINNQLDYEVELGVVIGKTGVN
                     IRKEEVEDYIFGYTVINDISARKLQKEHVQWFRGKGLDTFTSLGPCILHKSAVPFPIK
                     LKVCSRVNGEERQSSNTGLFISDVSDIVSELSKGMTLEAGDIIATGTPSGVGMGFSPP
                     RYMSSGDVVECEIESIGILKNYIK"
     gene            34963..35856
                     /locus_tag="KR257_000922"
     CDS             34963..35856
                     /locus_tag="KR257_000922"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891302.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dihydrodipicolinate synthase family protein"
                     /protein_id="HBH0029645.1"
                     /translation="MKAEFLTPVVTIFDEEGNLDKEGNKKVYDHLIDGGVDGLVIMGS
                     TGEFFNMSMDMQKELIDLVTSHVNKRVKVFIGTSRMCINESIELSNYAHNSGADGVMI
                     ISPYYFSLDDDSIELFYSEIAKNTEAEIYLYNYPDRTGYDLSPELTLRLARKHKNIVG
                     YKDTVTLMGHTRDLINTMKIEFPEFKVYSGYDENFIHNLMSGGAGCIGGLSNLIPEVC
                     SKWAEAYNNRDMEKVIEIQKYINKAMDFYLITNPFIPAMKKAMNIRGLQISDYMTAPF
                     VKPNEKQVCEIKKLMNELNIC"
     regulatory      35909..36090
                     /regulatory_class="riboswitch"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00174"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="cobalamin riboswitch; Derived by automated
                     computational analysis using gene prediction method:
                     cmsearch."
                     /bound_moiety="adenosylcobalamin"
                     /db_xref="RFAM:RF00174"
     gene            36318..37448
                     /locus_tag="KR257_000923"
     CDS             36318..37448
                     /locus_tag="KR257_000923"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728987.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="HBH0029646.1"
                     /translation="MKFKSNVLKQFFLIAMVIFMVGGLIGCSKSDKENKQASTGKKLE
                     LKYASGFSVEDLEDGIKKVTDGDNRELILIPKKIKIPEKYKNANIVRTPVDNVLIAST
                     TQACSLRTIDELDSIKAVTTEEQYWTIKEIKDLMKDGKIHYVGSNLAPDYEKIVDLNP
                     DLTIVSSGLSEADTKFIDKLKELGLNYVVDNEYKEQNPFGRMEWTSLIAAFYDKEDMA
                     TSELNKTVQKVEEVSKKIKNKAKPKVVWASVYEGSAYIAPKDSYVDNMIKMAGGINAC
                     ASIDSNEGRVSIEQLHEVAKDADIFVYSSSSDYAPNLDSIKSSAPVLADLDVVKNGNL
                     WVFAPDYYQSVDKTDELIVDLVEMFHPGTTGEKIKHYINYDK"
     gene            37520..38545
                     /locus_tag="KR257_000924"
     CDS             37520..38545
                     /locus_tag="KR257_000924"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429076.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="iron ABC transporter permease"
                     /protein_id="HBH0029647.1"
                     /translation="MDFINKMRIRNTTIFIVLIISMILTFLVCVAFGSVKIEFKEVID
                     VVLRGMDNTEHYKIIYNIRIPRVLATMVGGACLAVSGILLQIFFKNPIVEPYILGVSS
                     GSTLSVALMILGGYTLGFESVNSMSIFVAAFIGALIVMSIVILFANKVKNITTLLIIG
                     IMTGYVCSGITNVLQSFANSDKLKEFTMWSMGSFSGFTWEKVEILIIVGILGLLMTVF
                     IIKPLNAFLLGEEYAKSIGINIRFFRVLIVFISSILAAIVSAFAGPIGFIGLAVPQIS
                     KMIFKTSDNRVLIPVVIFLGSIVTALCDLISRVILSPVELPISTITSLLGAPIVVMLL
                     VKRKDRA"
     gene            38548..39744
                     /locus_tag="KR257_000925"
     CDS             38548..39744
                     /locus_tag="KR257_000925"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429077.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBH0029648.1"
                     /translation="MLKTNNLSVGYNNKVVISNINVEVKNGEILCLLGSNGAGKTTLL
                     RSLSKLISPIKGEIYLNGVNINCISRKALSKKMALVLTNRLLGDLMTVQDIVNIGRYP
                     YTGFFGSLSKKDLIMVDEALESVDALHLKKRYFDELSDGEKQKVLVARALVQEPEIII
                     LDEPTTHLDIKHRLELINILKKLSKEKSISVILSLHEIDIALKSCDKVALIKNNKVIA
                     YGQPEDVVDEDIINSLYELDDKNFNSLLGSVEISNKSKNEVFIIGGGGKATPIYRAFT
                     KKGIGLYSGIIHENDIDYEIGRTMGIKMFTENPFEPISDESFNLAIRNLNDSKIIIDT
                     GFSVGETNKRNIDIIKEALKLDKKVYSFRNRDESKKYYDSLDSKIEHIDKVSQIINSA
                     DINNLL"
     gene            complement(39872..40597)
                     /locus_tag="KR257_000926"
     CDS             complement(39872..40597)
                     /locus_tag="KR257_000926"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861779.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pentapeptide repeat-containing protein"
                     /protein_id="HBH0029649.1"
                     /translation="MKTISKQELEKTLEKHYLWLKNNNAGEKADLKELRLENMDLRGY
                     CLSNIDFSWSDLINLNLEKADLENSIFNNSYLSDCSLKNSILKNADLSGASFRFCDLS
                     NSDIRGANLENSNLEHATLNGVISDESTRFFKLYCPETGAFIGYKKCFNFRMVQLLIP
                     SDAKRVSATSNACRCDKAKVLSITSIDGKESFKSARAYADENFIYRVGETIVAEDFNE
                     NRWKESTTGIHFFLTREEAIGYL"
     gene            41075..43174
                     /gene="nrdE"
                     /locus_tag="KR257_000927"
     CDS             41075..43174
                     /gene="nrdE"
                     /locus_tag="KR257_000927"
                     /EC_number="1.17.4.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422595.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="class 1b ribonucleoside-diphosphate reductase
                     subunit alpha"
                     /protein_id="HBH0029650.1"
                     /translation="MNWIELNNQVIIKNEQGKYQLEKDKEALSSYIEEFIQPKLRKFN
                     NLEERLKYLIDEGYYSKEVINQYSIDVIKNIYDMIDKHKFEFQSYMSANKFYQNYALK
                     SNDGKEILETYNDKVLIVALTLGNGDKDLALNLADKIVKQEFQPATPTFLNAGRKRAG
                     EMVSCFLLSVEDSTEGISYAISSSNHLSKIGGGVALNLSKLRASGESIKDIEGAAGGV
                     VGVAKMLEQSFSYFNQMGARQGSGAVYLTVFHPDFELLMDTKKINADEKIRLATLSLG
                     AIIPDKFMELAEKNEVAYAFYPHTVYKKYGVSLDEIEMDEWYDKLVNDSDIRKKEINP
                     RQMLTKIAQMQQESGYPYVVYIDTANREHTLKDVGIIKMSNLCCEIFQYQTPSEIEGY
                     GGKNEWGQDISCNLGSLNIANVMDNKTIESTVETAIRALSFVADSTDIKPVPTVSNSN
                     SKSHSIGLGAMNLHGYLVRENILYTSDDAIDFSNVFFAMVRYYSIKASMKIAIERNQT
                     FEGFDKSEYVKGRNSKVLSKYYEQSYLPKSEKVRALFEGIYIPTKEDWTKLLDEVKEK
                     GIYNAYLMAVAPTQSISYVQNATSSIMPITEPVEVRTYGDSTTIYPMPFLTNDNMLYY
                     QSAYRMDMRKVIDLVATVQNHVDQGISTTLFVTDEKTTRDIARHYIYAYKKGLKSLYY
                     TRTKMTRDTHECLVCSV"
     gene            43186..44157
                     /gene="nrdF"
                     /locus_tag="KR257_000928"
     CDS             43186..44157
                     /gene="nrdF"
                     /locus_tag="KR257_000928"
                     /EC_number="1.17.4.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728983.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="class 1b ribonucleoside-diphosphate reductase
                     subunit beta"
                     /protein_id="HBH0029651.1"
                     /translation="MTFNLHKIHNAVNWNREEDGFTQAFWEQNVKQFWLPEEISVSKD
                     IKVWNELSNKEKELYKKVLGGLTLLDTKQGNNGIPSMMSLTENLQRKAVLSFMGTMEE
                     IHAKSYSSIFMTLLSNLEIDELFEWIETEPTLQRKADLVLAQYENTTNQEGLYLSMVT
                     SVFLESFLFYSGFFYPLYLSGQGKMVASGEIISLILRDESLHGKYIGLLAQEIYDSFD
                     KMDKEMLEEKMYSILYSLMENEIEYTNVIYRESGLEKEVVNFLKYNANRALENLGFEK
                     LYTVDAINPIVLNGLSTETKTHDFFSTKGNGYQKGVYEELEDEDFII"
     gene            44233..44859
                     /locus_tag="KR257_000929"
     CDS             44233..44859
                     /locus_tag="KR257_000929"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429081.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GyrI-like domain-containing protein"
                     /protein_id="HBH0029652.1"
                     /translation="MKYEWRKRDKELYLPKKNPVIVEIPEQKFIMLKGSGDPNSKEFT
                     EAIGVLYSLAYAIKTMPKKGIVPEGYFDYTVFPLEGIWDKGEKSKGLDVLIKEDLIYT
                     IMIRQPDFVTQDLLDKATDIVKKKKPHNLLEKVRFGSINEGLCVQMLHIGSYDNEPES
                     FDIMNEFCKKNKLIRKSYTHREIYISDARKVSPESLKTVLRFEVEREV"
     gene            45254..45883
                     /locus_tag="KR257_000930"
     CDS             45254..45883
                     /locus_tag="KR257_000930"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903387.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0029653.1"
                     /translation="MNKYLLINPVAERMYGEKFHLIKANLIKKGYIITECEPQLEYVK
                     KQYKEYTKKTENTMLDCRCPESISLLKRNNLINNFEVPMIEPILVRTCRVLYDKYIKS
                     KDDMLVVTCPCTQLRDFASEKFKDKGNAMFYTWKEFAEQEGVKSLGKIDESPIPLGYF
                     KDTFEKVLEVSSEDEILSEIQKIRNGFEDKYDIVEMFYCKDGCNNGDGL"
     gene            45884..46666
                     /locus_tag="KR257_000931"
     CDS             45884..46666
                     /locus_tag="KR257_000931"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429083.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBH0029654.1"
                     /translation="MVNKFNNKFLRLVKSVLIFFIILLLWKITNYLGIWSDYILPSPE
                     KVYSTFLNMISDGSIFINVYASMKRVLIGFAISTAIGVPLGIFFGIYSGVYEYFKSLI
                     NFLRNTPPLALIPMLILWFGIGEESKIIIIVLASFFPIFTSTLKGIKNCDSKLIEVGR
                     VFEFSKLQIIFKIIIPNAILDIAVGLKLALGYSFRAIIGAELVAASSGLGYLISDGKE
                     MSRTDVVIVGIIVIGLLGIITDYIFSIIVKKVSKGKMVEAYE"
     gene            46659..47537
                     /locus_tag="KR257_000932"
     CDS             46659..47537
                     /locus_tag="KR257_000932"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728980.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBH0029655.1"
                     /translation="MNNLVCDSGYIIRNLYKSYKVDNKEHVVLSDISLNIDRNHITVI
                     LGESGCGKTTLLRAIASLEGINSGEIRFINDNKEYRPNVGFVFQESRLMPWLNVSENI
                     AFHNQRKNTILNKVLRKFKHNKRIRSKIINDNFRSLETNDNLNKSNKYNRKSNIDVEK
                     YLKMMNLQKFKNSYPNELSGGMAQRVSIARALSFNPDMLLMDEPFSALDYFTRIDMQN
                     EVIRIHKSTNKGVIFVTHDIDEALKIGKKIVVFTDERKVKEFNIEDGYNRDLTSDYYI
                     KLKKDILMTMKSNKGI"
     gene            47570..48529
                     /locus_tag="KR257_000933"
     CDS             47570..48529
                     /locus_tag="KR257_000933"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728979.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NrtA/SsuA/CpmA family ABC transporter
                     substrate-binding protein"
                     /protein_id="HBH0029656.1"
                     /translation="MKLKKLLIGITILTLATASLAGCAKKNNGEKLSEINLTYVKSPL
                     NVPSIIQKQDDLFGKEFKKDNIKVNFHEITTGPEQTQALAAGEIDFLHALGGTSALIA
                     ASNGVELKILNTYSRSPKGFMILTNNNSIKSAADLVGKKVAGPKGTILHQVLISALDK
                     EGLSMDDVEFVNMGIPEASAALSDGSVDAALIAGPAALKAMKSGSKLVANGEGLVDGI
                     IVTAVSTDFAEKHPEIVERFMKVEKETLEYVNNNFDEAMEKVAKEVDLSLEETKELYA
                     WYDFSLDITDKDISSLEDTQDFLIKNKLQEKKVNIKELIYNAK"
     gene            48843..49535
                     /locus_tag="KR257_000934"
     CDS             48843..49535
                     /locus_tag="KR257_000934"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011987369.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HBH0029657.1"
                     /translation="MSYKVYIVEDDISISTLLKDYIEKYGFEVIVEENFDDIMITFES
                     FKPHLVLLDVNLPKFDGFYWCRCIRQQSNLPIIFISARDGNVDQIRALESGADDYITK
                     PFYYDVVMAKIKSHIRRVYGEYSPKIDERIVELDGLKFYPERLELELNGENLIITKKE
                     GILIECLIKRYPKVVSRDYLLEKIWDDIEFVEENTLNVNVSRIRKRFEELGIDNAVQT
                     VRGLGYKLNKNW"
     gene            49545..50549
                     /locus_tag="KR257_000935"
     CDS             49545..50549
                     /locus_tag="KR257_000935"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422603.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HAMP domain-containing histidine kinase"
                     /protein_id="HBH0029658.1"
                     /translation="MKLFLKDYKGYIFIYYIGIVMTIIYCNLMKFISFGESLYILLFS
                     SFILLCFLIYKYYKNREVYNLFEKGVHSLEESFLYLGSSFLGRNISVILKQQHKLYQS
                     MIQEHKKIHSEHLTFINQWIHQMKTPISVISLQLQDYEGEEVTENIRKEIDRLNKGLD
                     MAMHFARADNFQKDFIVEKAKLNEIVSSIVNEEKRLFIKSGMIPKIQVDKFTYVYTDV
                     KWMKFIIGQLITNGVKYSKDYSNYLTIKSEENNKYVILSIIDEGIGIVSKDLKRVFAP
                     FFTGENGRKFGESTGMGLYLVKKVCDDLGHKVSIKSEVGKGTEVSIYFNKGVNSLIKM
                     "
     gene            50797..51648
                     /locus_tag="KR257_000936"
     CDS             50797..51648
                     /locus_tag="KR257_000936"
                     /EC_number="3.6.1.27"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728978.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="undecaprenyl-diphosphate phosphatase"
                     /protein_id="HBH0029659.1"
                     /translation="MSLDVIFILKSVIIAIVEGLTEFIPVSSTGHMILVGNLIDFKGQ
                     FAEMFEVVIQLGAILAVVVLYWKKIKDSVIEFFKFIFTGGKEGKIGFRFGMNVIIGCI
                     PFAIIGVLFYDNIKSLFNLQSVIIGFIVGGILLLVVETLFRKKNHSTDNIDKITPIQA
                     LKVGTLQVLSAWPGMSRSASTIMGGWIAGLNSPTAAEFSFFLAVPAMVASSGKDLFEF
                     DYSIMTPTLWIALVVGFIVAFIVSIIVMEKFVNFLKKKPMRVFAVYRIIMGVVLAVLA
                     FTNIISV"
     gene            51752..52498
                     /locus_tag="KR257_000937"
     CDS             51752..52498
                     /locus_tag="KR257_000937"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001637630.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBH0029660.1"
                     /translation="MKILTVNNLSKVYGKKIIFNALNDINFSIEDGEFVGIMGPSGSG
                     KTTLLNMISTIDKPTTGTMELKGKNPLLLRGEELALFRRRELGFVFQDFNLLDTLTIG
                     ENIVLPLTLDKVSVKEQDERLNEVSTILGIKDLLGKRTFEVSGGQAQRTAIARALINN
                     PSILLADEPTGNLDSKSSKVVMELFQKINKENKVTTMMVTHDPLAASYCSRILFIKDG
                     SIYNEIYKGSSREQFYQEIMDVLTLLGGDN"
     gene            52498..54414
                     /locus_tag="KR257_000938"
     CDS             52498..54414
                     /locus_tag="KR257_000938"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003439793.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBH0029661.1"
                     /translation="MNIKQFAINNISRNIKAYLGYLASIVISSSLLFSFIMFTSHPDL
                     DVSQFPDYLKEGLKMSKIIAYLFLFFFVFYSVSVFLKSRYKEFGILYITGISKRQVMK
                     LIFIENMIINIVSSVIGIIIGLIFAKIFLVVMSTFLELSPLKFYIPFNAILSTLIYFM
                     ILAVLTSIFTSFIVKENQVLKLLKGTKTPKPEPKTSLMLAILSICLFIIAYYNAITST
                     DQYTTYLRLVPVTSLTIVATYLFFSQFSVFFMKKLKLNKRFYRKNTNMLWISNLIYKV
                     KDNARIFFLITITSAVAFTAIGTVYSFWKDVERQINLIYPNTIYYSTMTLHNDPKKPD
                     SKEKDKERMMFIENNLKKENVDYTRINGEFKTVFPKKSDFNVRIMKESKYLEITETIG
                     VKPISFEDNECISLLSSSLPGNKNVKENIIVGNRGLKVAKQVEECVMPAYYKNMYVVK
                     DNFYDSIESKFIVDRFTAFEVEDSSKTIEICREFENKFNNESGMQPYLFFSKELMIGT
                     GKLMYSTFIFLAIFIGLIFFVTTSSFLYNKFYMDCQVDKKKYEQLNKLGMTYNEIKKA
                     STIEIGIVFLFPYVVAVIHSIFALTALKNSFDIEVASSAVLVMGSLFLVQIVYFLIVR
                     NNYLKEIRLNLVNF"
     gene            54693..55610
                     /locus_tag="KR257_000939"
     CDS             54693..55610
                     /locus_tag="KR257_000939"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861773.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="WYL domain-containing protein"
                     /protein_id="HBH0029662.1"
                     /translation="MMILIQSRGKMKCKELSEELEVSERQIKSYKMYLEQAGIFINST
                     PGIYGGYEIDKCNSISLIKLLDSEVSILDMINSQLEYNNDIYKNEFNNIVEKIKAVLN
                     TGEKSDTYMDYFTVQAQRNCDYESEKNKCNEIIRAYTTKHKFWIEYYSLNSGNSERIV
                     HPYGLFNYKSDTYMVAFCEKRFKFIDFKLCRIKDYKVLEEKYNVDKSFSWDEYSKNSI
                     GIYKGEEINVVIKISHPFSTIIKEKVWVNNQQIIEYDDKSIMFKAKMRGYEEIKSWIL
                     SMGAYVEVVEPDRLRNDILLEIEKMKKIY"
     gene            55688..56425
                     /gene="cas6"
                     /locus_tag="KR257_000940"
     CDS             55688..56425
                     /gene="cas6"
                     /locus_tag="KR257_000940"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891270.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CRISPR-associated endoribonuclease Cas6"
                     /protein_id="HBH0029663.1"
                     /translation="MKMKIEFSTGCIPISYNSLFMSIIKEAIRKSNEDYYKNMYYYKE
                     KNNKKTKNFTFSVYIKKYSIEGDNFIIEDKVILNISTPDLELGFHIYNGLMTSKKCLY
                     KDYELTRIRIDLSREKKVTEERVLFNALSPICVKSKEGKFLEITDDRYIEELNYITNE
                     VVKNYRGNGLKRKLEFENIGLKKVVVKESLREFKKITGKEYQYINGYKGKFILKGDID
                     DLNLIYNLGIGFRRAQGFGDVDILEWR"
     gene            56431..58281
                     /gene="cas8a1"
                     /locus_tag="KR257_000941"
     CDS             56431..58281
                     /gene="cas8a1"
                     /locus_tag="KR257_000941"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893753.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type I-B CRISPR-associated protein Cas8b1/Cst1"
                     /protein_id="HBH0029664.1"
                     /translation="MKLRVYRGDWFFNMGIVGFLNIIKKADKQAEIFIMEDYIEFDSL
                     FLENFHEYYFNYFMDEYDVSKRIKKNIDYSINFIKSKPDRIKDGIKKIKDSVKQQNDK
                     IKKFDEEKFNMIKEKLDSMSKIKSYDEFDSLEALVDETIDIFKIKSINDRLTANLYKY
                     VVQDNYFGQVSFFNVAKAKLDLDGLKQVMFNDYLRQIIYFGELEDLLEENDYDKLKNY
                     LNDRLNSIAKDINEKKVSKSSINTIEKIMKEINKNFIKKNKSIEDIKKYMDSLEVCEM
                     CGLYKGILDEYSESNFAPLGVSTNNARNMFWNQAYVPSICDICKLILFCTPAGATYTR
                     KNYLINEENEFYLFVNMDTCINELFERNNSLKAQKSEYSDSKDENPFNQLIKSIVEEN
                     TLKSEWQLRNILFVEFKASIDSKKCKINYFNIPTYLAKFFVKENKKIQSIYDYKLKSN
                     VLDLILKSKDLKHLINNTLRNIVKSNLESNNKSNISGLSCFNVVQLRTILNNYKRGVY
                     KMDYKKLRKIYESGCEIHDYYIDKNAKNKIEGITYKILNLIKVGNKNDFMQTILRIFS
                     PSEKTPPEEILQIFVEEDLDFESVGYAFVTGLISGKYEGKDKLPNEKEEK"
     gene            58283..59197
                     /gene="cas7i"
                     /locus_tag="KR257_000942"
     CDS             58283..59197
                     /gene="cas7i"
                     /locus_tag="KR257_000942"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861770.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type I-B CRISPR-associated protein
                     Cas7/Cst2/DevR"
                     /protein_id="HBH0029665.1"
                     /translation="MKRGLTFTVIAQAQSLNYGEGIGNISELKKLSRDDGNIYTFASR
                     QCLRYDIVRLAAELFNWNLQVVDKEKGTIQFKDNISIRESEEMDLFGYMKTNKKDEKD
                     KKGGSLTREATVRLSNAISLEPYRSDMDFLNNKGLADRIGEHPNLANIEQHLSYYTYT
                     VTIDLSKIGKDGDIELDNKEKCRRVVEFLEIIKVLNRNIRGRQENLSPLFVVGGVYEI
                     ANPFFLGRIKLKGDKNGFKINKQAIEEVIQGTFLGKDLKEFTYVGMVDGVFINKEEFK
                     GLFEDNFLSVDKFFGQLVKEVKEYYGVN"
     gene            59199..59900
                     /gene="cas5b"
                     /locus_tag="KR257_000943"
     CDS             59199..59900
                     /gene="cas5b"
                     /locus_tag="KR257_000943"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422614.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type I-B CRISPR-associated protein Cas5"
                     /protein_id="HBH0029666.1"
                     /translation="MKVLKLDLFQETACYKKPFAMKITETYPLPPYSTINGLIHKILN
                     ATEYIPFNISVQGTYESIFNNYQTTYFYKKDSITSMPMNSHMLLNVNLIIHIGGDFDL
                     LEEIYDSLLNYDEHLSLGRKEDLVRINDIRFVEVNKFEVDEDIQLDDYENYKLSECNI
                     RMPIYIPKTSLQDTDIDGISYRLNNYYDNNAVEDKKRVWNKVDSYYVEDGNTISIGDI
                     LLDNEGDLLYFNNIN"
     gene            59911..62232
                     /locus_tag="KR257_000944"
     CDS             59911..62232
                     /locus_tag="KR257_000944"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898075.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CRISPR-associated helicase/endonuclease Cas3"
                     /protein_id="HBH0029667.1"
                     /translation="MLYAKSNPVETLREHTDELLKQMNVLRESYGKNINSLDFLEEEI
                     FWQLLDFVIEFHDIGKAFSPFQELIKSRMDTKINEPKIVTYLENNVGHNYLSPAFIDY
                     SYIDRKKNKELRAVLNQVIVYHHERDIFIDKDFKNLIQKILDEDLINKVYELQHEFKV
                     RYPIKTEKLSKVYLQSVEKRIDKNHKYYNLYIMLKGILHRLDHSASAHEVVECNNVIN
                     IGEQTENYLMKEFGSLREAQSFAKSNRNKNIILIASTGMGKTETALIWIDKDKAFFTL
                     PLRVSINALFDRAKNIVGVGESNDTFLGLLHSTAIDYLEESNQENSSEIVDLAKLLSC
                     KLTFSTIDQIFKFPFLYRGYEKVYSTLAYSKVVIDEIQAYSPEIAAVLVKGIEMIHKI
                     GGRFMIMTATMPTIYIDELKKRGVMNSNLAELTCNTEKIRHCVSIVENSIDENLGKII
                     QSGMNKKVLVIVNTVKSAVEKYELIEEIVKPKGIDVNLNLLHSMYIQEDRAKLEKYIK
                     EFANSDRNGIWITTQLVEASLDIDFDELHTENSTLDSLFQRFGRCYRSREYEENSPNI
                     FIYTEKATGIGSIYDKDIVEKGLELLKTFINGKECVKMKEKYKVEMVKILYSKESLEG
                     TAFEKRFTSALNILDTITPYSLGSKDAQNILRNIEGYTVIPEDIYNKIEETLIKDYEE
                     LGQELINAYSNDDRQLINKIKSKRKKARREIIKKTVNLPIYKAKQNVIDIQVKGLEDL
                     KILLYKYDIYENKHTKQIFGKGVLISNEIDQFI"
     gene            62247..62798
                     /gene="cas4"
                     /locus_tag="KR257_000945"
     CDS             62247..62798
                     /gene="cas4"
                     /locus_tag="KR257_000945"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012816355.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CRISPR-associated protein Cas4"
                     /protein_id="HBH0029668.1"
                     /translation="MWLKFTKEGDFVPIDLEVLKVQGVKINYYYVCKRKLWLFSKGIT
                     MEQNSSRVLSGKIVHEDSYKRMKNKEILIDDILKLDIIKDEYVKEVKISSKMKEADEM
                     QLYYYLYYLKNSMGIEKKGTINYVKEKKQEELILTEEKERIIENTLININEINMQLSP
                     PKIEKKHYCTKCAYYEFCFVKEE"
     gene            62801..63781
                     /gene="cas1b"
                     /locus_tag="KR257_000946"
     CDS             62801..63781
                     /gene="cas1b"
                     /locus_tag="KR257_000946"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003439781.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type I-B CRISPR-associated endonuclease Cas1"
                     /protein_id="HBH0029669.1"
                     /translation="MYKDYYIISNGDIKRKENTIYYYNLEGEKKILPVEQVDDIHIYG
                     EVDLNTKLINYISKYGVMLHFYNYYGYYSGTYYPRKKNVSGFSLVCQSACYLDKNERL
                     YLAKSFVESASYHILRNMRYYKVDESLIDTIKDELNDLNDVKEISELMGKEGRIRKTY
                     YKSFNQILKDDFEFYKREKRPPKDPVNALMSFGNSIMYTNVLSEIYKTQLDPTISFLH
                     EPSTKRFSLSLDIAEIFKPIIIDTIIFSLINNKRINKNDFEYQDKICYLSEKGKKKFL
                     QEFENKMQTTIKHRNLNRKVSYRMFIRLECYKLIKHFINDERYKVLKVWW"
     gene            63784..64050
                     /gene="cas2"
                     /locus_tag="KR257_000947"
     CDS             63784..64050
                     /gene="cas2"
                     /locus_tag="KR257_000947"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891261.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CRISPR-associated endonuclease Cas2"
                     /protein_id="HBH0029670.1"
                     /translation="MFVIVTYDIVEARSLNRIRRILRKYLTWTQNSVFEGNITEGKLH
                     KCISEIENIIDNSEDSIYVYEIKNPNSIKKKCYGIDKYSDEMFI"
     repeat_region   64234..64656
                     /inference="COORDINATES: alignment:crt:1.2"
                     /rpt_family="CRISPR"
                     /rpt_type=direct
                     /rpt_unit_range=64234..64262
                     /rpt_unit_seq="gttttatattaactaagtggtatgtaaat"
BASE COUNT        25607 a         6486 c        11338 g        21235 t
ORIGIN      
        1 tagggtaaat tgcaaaatat atacgaaagt aaaattttaa atattgacat taaattaaat
       61 atactatact atgtaagtgt gatgagagaa tttttttaga ggggatttat agtgaatata
      121 aaaaagatat ttaataacaa tgtagtagta agctccctag aagatggcac agaaataatt
      181 gtcactggtg ctggagtagg atttaagaaa aaagtaggcg atttgataga tgaaaatttg
      241 atttctaaga aatattttgt tcaagacgat caaagggaca aatacaatca aatacttaat
      301 aagacctcta ttgaatactt taaaatttca gaagaaatta tagaaaaggc taatgaagtt
      361 ttaaatactc aagtgaatga ttcaataata ttagccttaa ctagtcacat agaatttgct
      421 gtccaaagag aaaaacaagg tataaaatta ccaaacttaa tattgaatga gacaaaacaa
      481 ctttataggg aagaatttga atttggatta tgggcaattg atgaaattga aaaaaggata
      541 ggaataaaat tgcctgaaga tgaagcagga tatattgcta ttcacataat caatggtttg
      601 gaaaattctc aaaaagatga aggtattaat atactagagt tttcaaaaca agttattcag
      661 ataattgaag aagtacatgg atttaaattg gatgtaaatt cattaaatta tactagactt
      721 ataactcact taaagttttt tgttcaaagg attctccgaa aagaaactta caatgatagt
      781 gatattgaag atatgtataa gttagtgaat aaaaattaca ataaacctaa agtgtgtact
      841 gaagaaattg cagcattggt attagacaga tttgaatata agattagtaa agaagaagaa
      901 ttatatttaa tgattcacat aaataaaata acaaacagtg gttgttagga ttgtaactga
      961 taaagcaggc aaaacctaag tcattgagct taactattag attaagtttt ttgatttagg
     1021 tttttttatt agatacaatc aaaatacaga cagtgacttt taggattgta actggttaag
     1081 caggcaaaac ctaaatcatt gaatttaact attaggttaa gttttttgat ttaggttttt
     1141 ttattagata caatcaaata cagacagtga cttttaggat tgtaactggt tgagcaggca
     1201 aaacctaaat cattaaactt aattattaaa ttaagttttt tgatttaggt ttttctataa
     1261 atttgattat gtttttagat aaaaatagga ggggaaaatt atgaaaaaaa ataagttagg
     1321 tttatggaac ttcttccaaa tgttaggaaa aacgtttatg ttcccaatag cactacttag
     1381 tgtttctggg atgatgctag gacttggggc aggttttaca gaccctaaga tgattgaaat
     1441 ggttccattt ttagggaatg aatatgttaa cttagtttta aacttcatgt taacaatagg
     1501 attatttgca tttaacaact tgggagcatt atttgcaatg gcaattccac taggattatt
     1561 aaaaaaagaa aaagagtttg gtgctttttc aggattagta ggatttatag caatgcatat
     1621 aggtacaaat ttttatttaa caagagctga tttgttagta ccagcagaac agatgtcaac
     1681 taatggtcaa gctatgatta tgggtataca aacatataat acaagtgttt taggtggtat
     1741 tgtagcagga ttaattgttt atgcaatata tgataaagtt agtaatttaa agataccaga
     1801 atcattagga ttctacagtg gaccaagatt agttccaatt gttagtttaa tagttatgag
     1861 tatagttgga ttattaatac ctattgtttg gccaccattt ttcaatgcat tccaaagttt
     1921 aggaagatgg atttcttcag caggaccatt aggatatttt tcatatgcag tggcagaaag
     1981 agttacaatt ccatttggac taaatcatct tgtaacatct gtattccgtt ttacaccaat
     2041 aggtggaact gctgttattg atggagaaac gtactttggt acattgaaca tgtttatggc
     2101 atatgtagaa aataatcaga ttatacctct tgatttagct ggtaaaatgg aacaaggtaa
     2161 attgatgatt caatatggat tagctggtgc tgcattggct atctaccgta cagcaaaacc
     2221 agaaaataga aaggcactta aaggactttt aatatcagga gtgttgacag ttattatagg
     2281 tggtataagt gaaccaatag agtttctatt cttattcata tcaccagcat tatttgcttt
     2341 ccatacattt atgaatggta tagcaaacat ggtacttcca tacttaggcg tgttgatggg
     2401 attcacagga gatttaattg catttataag ttttggtgtg ttaagaggaa cagctacagg
     2461 atggccaata gcagtattag tagcagtttt atattttgca atatactatt ttgtatttaa
     2521 gtgggcaatt attaagttta atataaagac cccaggacgt gaggataaag aaataaaagt
     2581 atctgaagga aatggttcag atttcaaaaa tttgtctaca tataaaggac aacaaatgat
     2641 atctgcttta ggtggtcaat ctaatatatt atcactagat aattgtgtaa ctagattgcg
     2701 tttaaaacta caagatgtat cattaataaa tgaggatgca attaaagagg ctggtggtat
     2761 agcagttgtt aaattagatg agcatacaat acaagtaatt ataggaactc aagtgtattc
     2821 tttaagaaag cagatggata aagctatgga aggtcatttg gaggcatgta atgattaatt
     2881 ttgataaaaa agtagaccga ttgggtacat attgtaccca gtgggactat gtagaagata
     2941 gatttggtaa gaaggatttg cttcctttta caatttcaga tatggattta gagtttccat
     3001 ttgaaataac agaggtgttg caggaaaggt taaatcatag agttttggga tacagtagat
     3061 ggaaacatga tgattttaga aattcagtta cgaattggta tattaaaaga tttaattgta
     3121 gcgttgatag taactggata tattatagtc caagtgtaat gtattcaatt agcaaactta
     3181 ttgagatgtt aagtaatgaa ggagatggaa tccttataaa tactcctgca tacaatgctt
     3241 tttatgatgt gataataaat aacaatcgta atattataaa gtcacatctt gtaaatagga
     3301 atggattcta ttcaattgat tttaatgatt ttgagaaaaa gtgtaaaaaa tctaagatat
     3361 ttattttatg taatcctcac aatccaactg gtagagtatg gagtgagtta gaacttgtta
     3421 agatgatagg aatttgtaag aataatgatg tcaagataat atcagatgat atacacatgg
     3481 atattgtata tgacaataga atgacaccta tcttaaatgt tgcaaaggac tatttagatt
     3541 ctgtattcat ttgtacatca gcgtctaaat ctttcaatat accagcattg actgggtcat
     3601 atgtgattat accaaatgaa ggtattagaa ataaatttga aaatatcact agataccgtg
     3661 attttgtaaa ttcgccagca attctagcaa tattagctac aatggtctgt tatgatgact
     3721 gcgaatattg gttagatgaa ctattaaaat accttaaaga gaatcttaaa tatacgattg
     3781 attatataaa agataattta gaaccattga aattggtcat gccagaaggc tgttactttg
     3841 cttggataga tttttccgaa cttaaaataa gtggtgagaa attccaaaaa ttattgatgg
     3901 atattggaga agttgctatt atgtcggggt ctgtatatgg tgaagaaggt gagttttatt
     3961 taaggttaaa tgtggcatgt tcaagagaaa aacttgaaga tggtttaaat aggattaaaa
     4021 aaactatgga ttatattgca aaaagaattt tatagtagga agggagatag ttatgggata
     4081 tttaaaaaca atggttgatg ttatgactac tgaaatgaat gccataagat gtttaataga
     4141 tgaagcagga atagaatatg aaagtatagt tagtgaaatt gcaaattgtg aaggcaaagt
     4201 aatttttatg ggtgtaggaa aatctgcaca tataggtaag aaattggcag ctacatttgc
     4261 tagtactggt acacctagct tttttgtaca tgcaacagag gcagtgcatg gagatttagg
     4321 aatgattgaa agtaaggata ttacaatttt aatatcaaat agtggaaatt ctatggaagt
     4381 ggtaaactgt ataaaatata ttaaagcaat aggttctaag acaattgcat ttacttcaaa
     4441 cagaaattca gtactggcaa aagagtgtga ttatgcttta atatatcctg caaaggatga
     4501 agcagaccat ttaaatctag caccaacaac atcatctaca attactttgg ttttaggaga
     4561 ttctattgca tgtgcattat ctaagagtag taattttggt tcttcagatt tttataagta
     4621 ccatccagga ggaagtttag gtgagaagtt aaaaacagct aacaatggat aaaagcaaaa
     4681 aggagagtag tttttatgtt caaaatgttt aaaaaaaaat caataaaatc acccatatca
     4741 ggaaaagtaa tagagttatc taaaatacaa gatggtgtat tttctcaaaa aattatggga
     4801 gagggtgtag ctatagattc tacaggagac attgtatatg ctccaatcaa tggaaagata
     4861 gtagtagtag cagagactaa acatgcattt gtaatagaat tagaaaatgg gatggaactt
     4921 cttattcatg ttggtttaga tactgtaaat ttaaaaggcg aaggttttga ggtattggtg
     4981 agtatgggag aacaagtgaa ggaaggaaca ccaatgttga aaattaaccg tcctttgatt
     5041 gaatcaaagg gtatatcact tattactcca gttacaataa ctaatcattc agagtacaat
     5101 atgaatacat gtaatgtagg caatagtgtt gaaggtggga aagatactgt aattgagttt
     5161 aaataaagaa ctaaaataca aggttaatat ttataaatac ctataaactt atgttttata
     5221 agattgattg tatagatttg ttgtatagat ttgttgtata aaaaagaact ctttaattat
     5281 aaattaagga gttctttttt attttgtaaa tattgtttag atttatatag aaaaacactt
     5341 agtaataaat agaataaata agtatttata tagctaaaaa tctaaatagt tttgtttaaa
     5401 tatattttta tattttgtaa tttcaaatta ataaataatt agatttaata aacaaaaaat
     5461 aaaaatgttg attatattaa taaactttaa tataatatat ttatgaaaaa tgtaaactgt
     5521 gaaatggagg tagtaacatg aaaattgaaa atctttctat tgatgatatt aaacgaggct
     5581 atatatttaa tgatgattta aattgttata gttgcattaa atgtacaaaa acatatgagg
     5641 taggagaaat atataaaata ggtaatagat tctttgaagc ttcaaaagct attgaacttc
     5701 atatggaatt agaacatagt gattatttag agcaattgct taatagtgat tcaaaataca
     5761 acacattgac tgaaaatcaa aaacaattat ttcaattatt tattagtgat ttaccagata
     5821 aggagatagc aaaacaggtt ggagtatcca catctactat acgccatcaa aaatttattt
     5881 tcagagaaaa agcaaaacag gctaagctct atttagcact atatgaatct gtatttgaag
     5941 ataaatctaa taaaagtagt actataatac caatccatga acatgctcga atggtagatg
     6001 aaagatatgt agtaactgaa gaagagagaa aacacatttt ggatacatca tttgaaagta
     6061 tgaatccttt aaaattaaaa gtattttctt caaaagaaaa gaaaaaggtc gtaattttat
     6121 ctaagatttt ggaacaattt gaacgtggga agaaatattc agaaaaggaa gttaatcaga
     6181 ttttagaatc tatatatgat gattttgcaa caattagaag atatctaatt gagtatggtt
     6241 ttatgagtag aaataaagaa tgtacaaaat attggttaac ataattaaaa taataaattt
     6301 tactaatgtg taatgttatt tttatctagg gggaggagtc aaatatgaat gatgaattaa
     6361 aatctatttt atacaataaa ggtgtagaca ttgttcgctt tgttgatata tctgaatttc
     6421 caataaatca aacacaaggt ttttctaaag caattttatt ttgtataggg ttatcaaaaa
     6481 aatttattac agatatatac aataacttac ctacagatag tgatgagttt ttggaaaaag
     6541 aggagaaagt agaagaatta gctgactgga tttcaaaata tattcaaaat aaaggatata
     6601 gagcatattc tcaatcggag aaaaacaatc tagaacatgg atattttgaa aaagcctata
     6661 ttaatccaga aatgcaatca gggattagtc ctttaccaca taagacaata gcaaatatta
     6721 gtggcattgg atttatggga aaaaataatt tgtttgtaac agaggaatat ggatgtgctt
     6781 ttagcatgtg tacagtactt acagatgctc caatttctgt tgaaagatat cctttgattg
     6841 attcaaaatg tatggattgc aatgtttgtg tagagaactg tcctgcaaaa gctatacatg
     6901 gaaatgaatg gactttacct ggaaaaagag aatctattat tgatgtttca aagtgttttt
     6961 gtgtattgag gtgtatgatg agttgcccat ggtcattaag atatgcaaat caaaaataac
     7021 tttactagag aaggtattaa attgaatatt ataaaatttt taaaatgtaa gattatataa
     7081 gatttctcaa aataaaaatt tgtatagaac actcagaaat gagtgttttt ttattgggat
     7141 taaattatat tgatacaaag cttaactatt ttaatcatta tataaaattt gtattaaaaa
     7201 attaagaata acttggtaat agtgaaaata taatgagatt ataattgatt tataatataa
     7261 ctataatgat attgtaaaaa tgaaaattgt cctctcaaaa ttcccaaaga gagtaaaagt
     7321 cacttcagtt atagtcaaaa aaatttttct gtgaaaagaa tttagatttg aaaaggagga
     7381 attaatcatg gaaattgaaa ctaaaactcc agattggatt aatgtactag aattaaacag
     7441 taaaatagat attactggga aatatgatgt aagtaatatg atacaaaata ttgtctctga
     7501 taagtcacta gaaggttcca ttatatattt tccaaaaggt aattacttat ttgagaaagg
     7561 tattaaaatt agtcaacaaa taacacttca aggagattct tattatggag gaggtaatca
     7621 agtatcaaat ttagataaaa aacaatcaat cataggaaca accaatttta taacccgagg
     7681 agtttctaat atgagtatta ttacattgtc aggaacaagt caatgtatca aaaatattaa
     7741 tttttattat gatagtcatg atatagagaa aataccgcct aaaaatgtat ctgctattac
     7801 agaatatgga gaaacacaag gactatctca ttttgaacat ctgtttattt ctggattttc
     7861 agggatagga attgaaattc catactattc aactggtaat gatattactg ttagttcatg
     7921 tggtcttggt atgaggcttg gagagaagtc aatgctttct agtagcaaga tttacgaatg
     7981 taaaaatgga atggagatta ctactggtgt tagcttaaat aatgtgagaa tagaagaaat
     8041 aaaagaaata ggtattaata ataaaggatt tggttttaac ctgattatga atcttatggt
     8101 cgaccaatgt ggatattgtg gatttatgtt tgaaaaaatg tgctatagcc agataactgc
     8161 cagaattact agatgcggtc agtattataa aagtgttgat tataatgctt atgagaatat
     8221 ggaagatagg aaagaagaag cttattccat tttttatgga gatattttag aaaattgcaa
     8281 tattgtattg atgaatagta atattgatac cttggaaaat gattcacttg atgaacataa
     8341 gatatatgta atcaaggcaa atgaaacaaa caatgtaatg ctaacatgtt atgctgaagc
     8401 agataacttt atacaatgtg caaagggcaa cttgctgtta gaaaatggtg aaaatactta
     8461 taaattttat aatggtgaga tttgttctgt aggaggtgtt caaatttctg atatagatga
     8521 aaaagattta atcaaaataa tagagaacac tttgtatata gatgataaag gtaagtattt
     8581 aatggttcct agattaaaaa agaatactgt aatatattca gtactagatt ctacagaaga
     8641 aataaataaa ttacatggtg gaatatggga acagattgat gtaaaagtat tagctgggga
     8701 atccatgtac tattataaaa agataaaaga ttaaattatc aaactaggag gtagtgatta
     8761 atggaagagt ctataataat taaagatata agtggctgga ttaatgtcct tgattatgga
     8821 atttgtaatg atgaaacaaa agatgtaagt tttaagttgc aagagattat ggatgctgta
     8881 ccagaagatt ctattatata ttttccaaaa ggaaaatact tatttgaaag tggtgttaag
     8941 attaagaaac gattaacttt atgtggagat tcttatattt tggcgaatgt tcctaaaaat
     9001 actgctggag taacacaatt tacttttaaa ggaaagaaaa atcctaaaag tgaaaatata
     9061 gcaattataa cagcaaaaag tgtaagacac tgtattaaga gcatttgctt ttattcagat
     9121 agttgtgata gagatatgac atctaatcat gaacctccaa cagatggaaa acctagattt
     9181 catcataatg taattataaa ttatagaaat atatcggcta ttgtatgtga agataaacag
     9241 ggagaatcag gtcattataa aaatctatct tttagtggtt tttctggaat tgcacttgat
     9301 atgcctaata attctacagc aaatgatatt acaattttta catccggact tggaattagt
     9361 acaggagaaa attcaactat tgctaacagt aaggtttggg gctgtgttga tggaatgata
     9421 atttctactg gaacttttat aaatggtatg agggtagaag aaataaaaaa agttggaatt
     9481 aaaaatattg gtagaggttt aaattttatt acaaatatca caattgacca atgtggatat
     9541 tgtggagttt ggtttgattc tatatccaat gttcagatat caggaaatat cacaaggtgt
     9601 gggcagtact attatgatgt aagctatgat aattatttaa tgttggataa tagagttaaa
     9661 gaagcatatt ctttattcta tggtaattta ttggaatcaa gtaatatagt tttatcaaat
     9721 accaataaag ataattggga agatttcaaa gaagataagc ataaggtgta tcttgtagaa
     9781 gcacttgaaa ccaagaatgt actattaaca tgcaatatag atgctactga ctggattgtt
     9841 aagtcagaaa aaggaaattt aacgtacaat aatatgcgac aaactgttat attttacgat
     9901 ggaaaactaa gtagtatcaa tggaattggt atatctgatg aagattatgg ggataaagtc
     9961 aagataaaaa aaggaaatat atatataaat agtaaggata aggatattaa gatgcataaa
    10021 ccagaggtag gtgacattat gtcaacaatt attaaagata aaagtattct ttctgctcat
    10081 tatgggggaa catgggagaa aattggtgaa aaaatagagt ttggaataac tgtacactat
    10141 tataaattga tagagaaata agtaaatacg tagtatttga atagatgtat tttattggag
    10201 agctaggact atagttttaa tgtaaatggt ttggtaatag catggattga ataatataaa
    10261 aataatataa aaaattaatt tgattatgta aaattctatg aagtagtaaa actgtgactt
    10321 tagtcatagg aggttcaaac taagtaaaag ggaaaggaat atataatatt atggaaggaa
    10381 gaactgggat taaagatgga agatggatta atgtagtaga aagaggtatt aaaaatgatg
    10441 gttcgtacaa cgtaggtcct gctttgcagg atattattga tgaaatagaa acagattttt
    10501 gtgtcttata ttttccaaaa ggtaaatacc tatttacaag tggtgttaaa attaataaag
    10561 aaattgtatt gcaaggtgat tctaattcat ctacaggcac tacacaattt ataactcgtg
    10621 gagtagaaaa tatgagtatt attacattga cagggaaaaa acaatgtatt aaaaatataa
    10681 atttttattc tgatagttgt gagatacagg taaataaaga accaccgaca aaaggtaatc
    10741 ctaaatatca ttatgagatg attattaata agaatgaaaa gaatgttgag atgaataatg
    10801 tatcagcaat cctgtatgat aacagtaaga atatgattaa aggtctaggt cattatgaaa
    10861 atatttatat aagtggtttt tcgggtacag gaattaggat accatattac tcaattgtaa
    10921 atgatattac agtttcatct tgtgggctgg gtattgatac aggaatagac acaattattt
    10981 ctaatagtag aatatctaag tgtcaaaatg gaatgaggat tagaactgga actagtataa
    11041 ataatgtaag gattgaaaaa atacagaaag ttggtcttat aagtagtcaa gttaaggggt
    11101 atgaggggta tggaagttat aaaattaata atattacgat tgaccaatgt gggtattgtg
    11161 gcttttcatt tgattcaatg aaagatagtt atttttctgg tattataaga aggtgtggtc
    11221 agtattatta taatacagat tatgacacat atttaagtat taaagataga gtagaagaag
    11281 catattcttt attttatgga aattatttta cagaatgtaa tattgattta gttagtgata
    11341 ataaggataa ctgggatgat ggcttagaat ataaacataa agtttatgta tttaaaaccc
    11401 ttcaaatacc aaaattaaca ttgagatgca atatagatgc ctatgattat atcgttaaat
    11461 cggtacatgg aggaggtaat ttaatgttaa aaaataattt taacaattat atatttattg
    11521 attcatctaa tccagaagtt attaatggaa ttaattttaa ttatcaaaag aatggaaact
    11581 tgttaaggtt aaataatggt aaattaagtt ataaaaatgg aaaggaagaa acagctatat
    11641 tcagacctaa ttatggtctt attgtagcat caacagattc agaatgtgaa caaatagaga
    11701 ctagctatgg aggaaaatgg gagaagcttg gttctgaagt aattggagaa gaaacggtat
    11761 attattataa acatcatgaa ccagataaaa caaaccaaat acaataaaat ttgtattata
    11821 taatgatata aagttttaat atatagtgtt tacctttaat gtaatattgg tatatttgta
    11881 tagtattaaa tttgttaaaa agtaaaattg tagggtgctt gaaaatagca ccttttttag
    11941 tttcattata aaattagttt tgaaagttta ggaataatgt atatttattt ttaaagaatt
    12001 ataaccttat taaggatatt ttaaatgcta gaaatgaatc agtaaatcat actggaatta
    12061 tcttaaatgt tttgattaaa ttaagtattt agagctataa ttatattaaa aatatattag
    12121 aacataatta tattactatg gaggttaaat atgatagtaa gtgtgagtag aagaactgat
    12181 atacctgctt tctatagtaa gtggtttttt aacagactta aagaaggttt tgtttatgta
    12241 attaatccaa tgaatccaaa acaggttagt aagatagagt taaatccaca tactgttgat
    12301 tgttttgtat tttggacaaa ggatgtaact ccaatgttat atgatttaaa taaattaaaa
    12361 gactataaat attattttca ctatactata acatcatatg gaaaagaagt agagacatgt
    12421 attttagata aaagaaaggt aatagattca tttaaggaat tgtctagaaa aataggcaaa
    12481 gaaagagtaa ttttaagata cgacccgatt ttcttaagtg aaaagtacac agtagattat
    12541 catatcaaag catttgcgag tttatgtaat cagcttgatg gatttacaga aaaatgtata
    12601 ataagtttta tcgatttata taagaaaaca aaatttaata ctaaagcatt acatataaag
    12661 ccaatagaaa ttacagaaat agaaacatta tcaaaagaga tttctaagat tgctcataag
    12721 catgggataa cacttgaaat gtgttctgaa gaatataatt taagtaaatt tgggattgga
    12781 aaaagtaagt gtattgatga tagattaata tcaaaaatta taggatgtga agtagaggta
    12841 aaaaaagata gtacacaaag agatatttgt ggatgtgtta aaagtgtcga tataggacaa
    12901 tacaatactt gcagacatta ttgtctgtat tgttatgcta actttaatta tgcaaaagta
    12961 gaagaaaact gtaggcttta taaagaagat aataaattac tcatagatac tttaagagat
    13021 gatgcaaaaa taagcattag agatatgaag actattaaag tagataagaa taaacaaatt
    13081 agtatatttg attaaaataa atatactaat taccttaata tattaagaat atagatactt
    13141 ttgataacaa aattaaactt aatagatatt ttctatataa gaaagatggt cataatatgt
    13201 caatttgacc atctttttga tataattaaa acacaaataa tttagtaaca aaggaggcag
    13261 aacttgaatt tattaaaaaa atatcctata cctattgcaa gtttgatttt gtcaatcttt
    13321 actttaggta acttattaca atcttatagt gaatcattac gtaatgtaat tggatttata
    13381 ggatttattt tgtatgcaat ttatatagtc aaaataatat tacttagaaa gggtgttaaa
    13441 gagcaattag agaacacttt aatatcaagt acatttccaa ctataacaat ggcaacaatg
    13501 atatttgcta catatataaa accattatct ttagaattaa gtattatgat ttggagcata
    13561 ggaattgtgg gtcatcttgt gttaatagtc ttatttagta agaagttctt agttaaattc
    13621 tcaataaaaa cggtatttcc atcttggtat atagtatatg ttgggatagt tgcagctagt
    13681 gttacggcac cagcatttaa tcaacttttg attggcaaaa ttgctttttg gataggattt
    13741 gtatcttata tagttcttat accagtaatt ttaaagagag tatggataat caaggaaatg
    13801 cctgaaccat ctttaccaag tatagctata ttagctgcac cagggtcact attattgtct
    13861 ggatatatta attctttttc agataaaaat aatgtagtat tatacttgtt attcatatta
    13921 tcaattgtat tttatattat agttttggga tatttaccga aattattaag attgcctttt
    13981 tatccgagtt ttgctgcatt tacatttcct atggcaataa gtgcaatggg tatgaaacta
    14041 atgaatggtt atttaactaa atcaggtcat tttataagtt ggatttcata tgcttctaag
    14101 ttagaagaga taattgctac agtgattatt ttatatgttt tagttttgtt tattatatat
    14161 cttagtaaat ctgaaactac atctaaagct aaataagaat tattaaatat gtgtatttaa
    14221 taggaatatt gatataaata tatgaagata agataaacca tagaaactta atttagctta
    14281 attttattgg aggaaaacaa atgaaaacaa aagaagaata tttaaaagaa gttagaaaca
    14341 tatcagaaga atactttaga aaaggagagt ttttttgctc tgaagcagtt ctccagacaa
    14401 taaatgatgc tttaggccaa cctttaagtc cagagataac taagttagca tcaggatttc
    14461 cgataggact tggaaaggca caatgtcttt gtggagcaat atctggggga gagatggctt
    14521 taggtatagt atatggaaga gttcatggtg aagctatgaa tccaaagatg tttgagcatg
    14581 ctaaaggttt gcatgattat attaaaaaag agtatggtgc aacatgttgt agagctatta
    14641 caaagaaatg ggatggtgat aactttatgt ctcccgaaag aaaagagcac tgtattaaaa
    14701 taacaggtca agttacagag tgggttgcag ataagcttat agaagatgaa aaacttaata
    14761 tcaaatagtg taatattagt tggtgaattt ataaagttaa atttacttat agtataagat
    14821 acttgatatt ctcgtattga tagaaaaatt tatagcatat gtatttaatg aaatatactt
    14881 atatttagag tgtggtttaa tttcataaat acatatgcta ttattttaag tatataagca
    14941 aatttattta aataaataga aacagttaat ttatatgtac aaaactatat atgattagtg
    15001 taaataaata cctattttat aatactcaac ataaagacac cagacatgat tagtattata
    15061 ccaataaaaa tagcaagcca ttcttttttg ttcttctttt ctttaaaaaa tataatccct
    15121 cctaaagtgg ctactatcac acaactctga gagatagaaa aacttattgt aactcccaat
    15181 gtattagtcg ttatgaacat acctaaattt gctattgacc acaatatacc agtaattaaa
    15241 ttgaataaaa cattttccct atatacaatc tctttagaaa aatacttgac aataatagat
    15301 gaagttatca acataccaac agattgaggt aatataattc tatatccttc aattaaaaat
    15361 atttgattag ttacaacata taatgataaa aatagagatg ataataatac aactccaaca
    15421 cattttaaca tatttttatc tgtagatttt ttagtttgat aatttgtgag aagtatacca
    15481 agtattatac ataatattga taaagaacca atcagtaaca ttttagaact ggtccattca
    15541 ttaaacaaga ttacagctaa taatgtcgta aaagttaatt gtgaaccatt tgaaattggc
    15601 attactttag atacactagc aatttgaatt gctttaaact gcattaattg tcccaaactc
    15661 cagaatatgc cagaaatcat acttatacaa aatgaaaaaa atgtaatttc aggatgtata
    15721 accagagtta ttatagtgga aaatataaac gcacttatgg atgtacctaa aagctgttca
    15781 tgaggagaac ttttctttag atttgcaact atgggcatca atccccatcc cattacagga
    15841 agtaaagcaa taattattgt cagcattaaa ctatttcctt tcatattaaa tttagacagc
    15901 ttttaattta tcatctaaaa ttaaagtgtt caatacataa aaattaccgt atttaatcag
    15961 gaaatattag tagtttttta gaaaaacatt ttccattaaa ataaagacaa agggaaggag
    16021 taaaattgaa aatgttaact gatatgattc aaaatcgtga aattaaaata ataaagtttt
    16081 tattaaaaga aggtcataca actgtaaaag caatagcaga tgatttagat gtttcagaaa
    16141 aaacagtttc aaaatctctt aaagaagtag aagcagtgct taaaaagata ggtctttctt
    16201 taataagaaa acctaagata ggtgtttata ttgatggaga tttaaaaaaa atacttcctt
    16261 acctagataa taaaggaagt caaattccta caaccagaga ggagagagtt atctatatat
    16321 attcagtact tttaaagagt aatgattata ttactataca acaactttct gatgaactat
    16381 atataagtcg tggaactatt gaaagggatt tagcagaagt tgaaaaactg ctaaaaaacg
    16441 aagggatttc catatataag aaacctagta agggaataaa gttaaatata agtgaaagag
    16501 ataaaagaca acttactgct aagtttatac ataaattttg gagtagaaac tggtatatta
    16561 agcaagagca agaaagcttt tatcaagcat ttgaaaagat acaagcagat gtaaatggta
    16621 ttttttcgga agatgattta tcaataatta ttgatattct taggaatttc agcagagaaa
    16681 gaaaatttga gttctctgat tatgaatttc agtcattagt tattcatttg gcaatagctg
    16741 tagagagaat tagaaaaggc gaatatatag aagaaagttt gtatactggt aatatagaaa
    16801 ataatcaaat gtcaaatacc aattatttag caaaacaatt agaagaaaaa ttttcaatat
    16861 tattaccaaa atctgaaatt ggatatataa atttacattt agtagcgtct gaccaacata
    16921 gagatactaa tgaactaaaa aatacttcaa ctaatccttg tgagacaagt acaaataata
    16981 tatcaaatct tcgggaaatt ataaaaaata cattgtatga gacagcttat gacaaggatt
    17041 taattgatgg attgacttca catgtacatt catcaataaa tagactgaaa tatggactta
    17101 gtattaaaaa tccatatgta aatacaatca aacaaaactt ttctttatca tttgagcaag
    17161 ctttagattt aaagaaagta attgaattta tatatgatat taggataaat gatgatgaat
    17221 gtgcttatat agcattacat tttgaagctt ttagagaaag aatgaaagaa cttccacaaa
    17281 atattagagt aattctagta tgcagtacag gattaggttc atctaggtta ttgtctgcaa
    17341 gaataaaaaa atactttcca atgataaaga ttgaaaaagt actttccgta caagaattag
    17401 tatccagtaa aattgatgca gatttagtaa taagtactat ttatttagag ttagaaacaa
    17461 ttccaaccat agtagttagt cctattttaa atgaaagtga tataagaacc ttggaaagaa
    17521 atatacaaaa tgtttcaagt tgtacttcta agaagtataa atctttcaga aacttaatct
    17581 ttgaagaaaa tatattgttg aatattgaag cttcaaacta tgaagatgca attaagtata
    17641 taacagataa cctaataaaa aaaggttttg caaaagaagg tatagctaaa agtgcaattg
    17701 agagagaaaa tttatcttac acttctttcc aatcaatagc tacacctcat gctaatccta
    17761 gttatattaa aaaatctaat atatctgttg caacgttaaa aaatcctatt acatggggaa
    17821 atgaaaaggt ggaagttatt ttctttattt cattagaaaa tgacaaaaac ctagagcttg
    17881 atgaaatata tgaagttttt tatgacttta ttgacaataa aaaaaatata aatgacatat
    17941 taagtgcaac ttccacaaag gaagtgtacg atttgctagt ggaggagagt atatagtgaa
    18001 aatatcagat gtattgaaaa aagagcaaat tgtttttaat cttgatacaa atacaaagga
    18061 agaaacaata aaaaaattaa gtagtatatt tgttgaaaat gggattgtgg acaatgaaga
    18121 agaatatgtt aagtctgttt tggaaagaga agaacattca actacaggta ttggtaatgg
    18181 tattgctatt cctcatggga aaagtaatgc tgtcaaaaaa tcttctataa tatttgcaaa
    18241 gactaagcat aagattgaat gggatgcttt agatgaaaaa ccagtagata gtattttctt
    18301 attggctata agcaatattg ataaggatag caatcatctt gtactattat ctaaattagc
    18361 aactaaactt atggatgatg acaatgtaga tgcactaaaa ttagccaatt cagaacaaga
    18421 aataatcaat atatttagtg aagaaggaga gatgtagaaa tgaaaagaaa aattatagca
    18481 gttacagcat gtgcaacagg agttgcacat acatatatgg cagctcaagc attaaagaaa
    18541 gcttcaaaaa agatgggtca ccttataaaa gttgaaacac aaggagctac aggaatcgat
    18601 aatgagttaa ctacaaagga tgcacaaatt gcagaagtag taatatttgc agtagatact
    18661 aaagtcagaa atgctgaacg ttttgaggga aaagaaatac tagaagtacc agttaatgca
    18721 cctataaagg atgcagagaa agtaataaat gatgcattaa agttaattga cactaaataa
    18781 atggagggaa atgtaatgtt gaaaaagata gtctctgagt taaaaaagca tgtcttaact
    18841 ggaatctcat atatgattcc attagtaatt gcaggtgcta tgataatggc gatatctcgt
    18901 gtaggtggtt ctttctataa tataccagat atatgggatg ctaaatatgc agaaagtgct
    18961 agtagtattg ttagattatt acatgattta gatgggtttg gaggtactgc attaggatta
    19021 atgtttcctg taattgctgc atttatagga ttttctatag ctgataaatt agctattgta
    19081 ccaggtcttg ttggaggtat gattgctaaa gatataggtg caggattttt aggagctttg
    19141 gcagttggtc ttatagcagg atatacatgt ttgtttatta aaaatcatgt taaattacca
    19201 aaatcagcag cttcaatagt accaatattt atagtaccag tatttgggac attaatcact
    19261 gttgtattaa tcaattatgt gataggtata ccttttgcca cattaaatac tggattagaa
    19321 aattggttaa atggattatc tggtacaaat cagatactaa tggcagctat tataggggct
    19381 atgatggcag ttgacttagg tggaccagtt aataaagcag ctttaacaac atcacttgca
    19441 ttattaacaa gtggaattta tgcgcctaac actgctgcaa tggtaggaat agttatacca
    19501 ccactaggat tgggacttgc tactatacta gcaaaacaaa aatataataa acagttacgt
    19561 gaagctggaa aatcatctct tataatgggt ttaattggag taagtgaagg agcaattcct
    19621 tttgcggtag aatctccatt aaaagtaata ccttcatgtg taattggaac agcaattgct
    19681 tcagctatgg cagttggttt aggttcagta aatgcaactc caattagtgg attttatgga
    19741 tggtttacag tagagaattg gccaatgtat gtgttatcaa tagcagttgg aacagtaatt
    19801 gtagctggat tagttatagt attgcgtgga aatccagtga ttgaggatga tgaatttgaa
    19861 gatgatgatt ttgatgaagc agagtgggaa tcttaaaatt taataactat ttaagacgtg
    19921 ttataagcta tattcaatat gaatcttata ctaaataaag tgttaaatat tcagtttaga
    19981 cttaaatata aaagataaag aacagaggag aataaatgat aaaagcacat attgttaatc
    20041 atacacactg ggatagagaa tggtatttta cttctggaga tgcattagta cttagtgaac
    20101 aactatttac agatgtaatt gatgaattag aacgtaatcc agatgtaagt tttgtacttg
    20161 atggacaact ttctattttg gatgattatg tacaattaca caaagaaaaa atagaaatca
    20221 ttaaaaagtt aataaaagaa gatagactac atattggacc atggtttact caaactgatg
    20281 cattctttgc tagaggagag tctattttaa gaaacttaat gattggaatt tttgaaagta
    20341 aaaagtatgg taagtatatg aaaattgggt atttgccaga tacatttgga tttaatgcac
    20401 agatgcctat actattaaag catgtaggtc ttgataatat attcttttgg agaggtatac
    20461 atcttggtaa acaggttcaa tcaccatatt ttaagtggaa aagcttaaat ggagaaagtt
    20521 atatatatgc agtaaatatg ccacatggat atggaactgg tatgctttta gagccttcat
    20581 taaagtatgt taatggacgc ttagacccag ctattgattt tattaaatca tatactgatg
    20641 tagatgaggt gttaatacct tctgggaatg accagttaaa tataataggt gatttcaaaa
    20701 ataaaattaa agcgattaat gatatcggaa agtattcata tataacgagt tcatatcaag
    20761 agtttttaaa atatataaag tccatagaat cactagaaag ctatagaggt gaatttagag
    20821 aacctgtatt agcaagaata cataaatcaa ttggttctag tagaatggat ataaaattag
    20881 catgtgataa actagaaaac aagctgatta aaagaataga gccattatta gtaattgcta
    20941 aaaagagcaa aattgaaata agcaatcagt tacttataaa tacatggaaa aaacttttgg
    21001 aaggacaagc acacgatagt ttagctggat gtgtaactga tactgtaaca gatgatattc
    21061 ttcaccgtat aagagaagca aatgaaatat gtgacagtat tgaaaatact attgtaaaaa
    21121 agatttcaga agggcttaaa ttatctaaaa atgatatttt agtatttaat acagaagcta
    21181 agcgttttaa tggatataaa gagatacaag ttgtaagtga tagtaaaaat atttatttta
    21241 aagataattt agatgctact ataattgaag aaacttatgt aaaaccgaga gaaaatgtat
    21301 tagaagaaac acctgctggt aatatattta ttgaagaacc aggatattat atattaaaag
    21361 taagaataaa tgtacagctt cctgcacttg gttataaagt tgttagtttt gaattaagtg
    21421 ataaagaaat ggtgtcactt gataaatcta atgacacttt tatatctaat gataattata
    21481 agataatata tgaagatgga agcttaaatt tacaacttaa agatggaact tacatatcaa
    21541 actttttaac attaaaagat agtggtaatg caggtgatac ctatgacttt tctccactaa
    21601 aaaatgatga gaatataaaa ctttcgtttg ataaagtgta tacagaaaaa gctttaggat
    21661 atgaaaaaat ggtggttaaa ggtactactt tactaccact tacattagaa gatagaaaaa
    21721 acaaatatct taatggtaaa ttaaatgtaa aagtaagtat tgtcttatct aaagaaaacc
    21781 cattgatgga tgtaaaactt tgtgttgata acacgatata taatcataga ctacgtgttc
    21841 atataaaaac tgatataaaa gataataaaa acatagcatc attgccattt ggatatataa
    21901 caagaaaaaa tggagtttta gacaactggg aagatattta cagtgaaatg cctatagatt
    21961 tagaaccttt ggaaagtaat attacgctta caaaccaaaa tagaagttgt actgtattta
    22021 ctagaggaat aaaagagtat caacatattg aagatgaaat tgcattgacc ttacttgcta
    22081 ctacagatga actaggaaag cctgatttat tatatagacc aggacgtgct tctggtgata
    22141 caactaaaaa aggtcatata agaattaaaa cagataaagc tcaaatgctt aaggaattag
    22201 aattttcatt tgcaatatat atggattcta aatcatttga tgaattggaa attgcgaatt
    22261 taacccacaa ttatctaagg gaatgtgtaa attatcaatt acaggattac aatttctttt
    22321 tatatcatat agataataag attcaaaaat caattgtcaa taaaactgta agtagagaat
    22381 tagaaataat atctttacca gaaaactatc ttatatcagc atgttatcct tcttattaca
    22441 gtaaagataa atttataata agagtggaaa atccaagtag taatagaatg atattggatg
    22501 agcaaatatt taaaaataga aatgggaaaa ttgtaaatgc aatagaagat gtagaagagg
    22561 aacaggtata tgaaatagca ccttttgacg ttatttcaat attattggat ttataagtgt
    22621 aaaagtaagt ttattgttta aagtctgaca gatattaatc tgccagactt tttaatttgt
    22681 ataaatttgg gtaaatatta atgaatggtt ttagtattta agtatgaatt tagtatttaa
    22741 tatagaattt attgaagtag aataattagt ttaacaggat aagcagttta aataaagaat
    22801 tattatatta gagtgatttt atatataatt taaaataata aaattttaat aaaatgagtt
    22861 aaagattgta tattaataga gttgatgtag ttacaaaaaa gttaccaatt gttatgtatt
    22921 tacaaaactg atatattaat tacataaaat ctaaaatagt ttgtaatagg agtatatata
    22981 ataaaaattt taattaaata aagctaggta tatttataat attaataaat atattgctat
    23041 aaaagtttgt ttaataaatt aaataaagaa aagaggagaa taaaatgtac aacatagatg
    23101 atatgatata taattgtcca gtagaagctt tatcaaatat tttaggtaaa aaatgggtgg
    23161 ctataattat atggaaaata caagaagata aaaaacgatt tggagagcta caaagagcta
    23221 taccagactg tagtaagaaa atgttagttc aacaactaga ttttttaatt gaacagggga
    23281 ttatagtcaa ccaaaaaaag ttggttaata atgttgtaga gtcaacatat tttttaagtg
    23341 aatcaggatt acgattgctt cctgtcatgg aaaaaatgat tatgtggagc aataaaaatt
    23401 taaattgtga taaatactaa aatttactct gtaagtaatg aaaatttaat taagctatga
    23461 gtagaaaaat gtattaaaat tacataattt tttagttaga ttttaattta gaaatgggat
    23521 tgtaatattg gaaataaaat aaggaggaat tttaatttgc aaaatgtaaa tttattttta
    23581 gtatttatag aaggtatagt atcattcttt tcaccatgta tactgccaat tttgcctatt
    23641 tatttgagta tattgtcaaa tagtagtgta gaaaatttaa aagaaggaaa gacgagtttt
    23701 ataggaagtt ctttatttaa aaatactata ttttttgctc ttggaatctc aacaacattc
    23761 tttatattgg gttcatcagt aaaagtattg agtatgtttt ttaatgaaaa taaagattta
    23821 ataatgttta ttggtgggat tataattatt atcatgggat tattttacat gggaataatt
    23881 aaatcttcaa tattgaatag agaaaaaaga tttaatgtta agtttaaaga aatgaaagca
    23941 ataacagctt ttatattagg ttttacgttt agttttggat ggacaccttg tattggtcca
    24001 atattggcat ctgtattagt catggtttca agttcaagta atcatcttag tgccaatctt
    24061 ttaatagcag tatatactat tggttttatt ttgccattca taattacagc tatgttttac
    24121 agtaaactat ttaaaactat agataagata aaatctaaca tggaaattat taaaaaaata
    24181 ggtgggatta tacttatagt atcaggaata ttaatgatgg taaatggatt tggaagtata
    24241 agcaaacact ttaatacgtc acaaaatagt aaaattgaaa gcaagcaaga agaaaataag
    24301 cgagaaaatt ctactgataa agaagaaaat tctgatggta atgatagtca aaaagactct
    24361 aataatgaca ataatgataa agggtctaat gatgaagata gaataaagtc tattgatttt
    24421 actttaacag accagtatgg taaaacacat aaattaagtg attatgaagg caaagttgta
    24481 ttcttaaatt tctgggctac atggtgtcct ccatgtaaag aagaaatgcc ttatatagaa
    24541 caactgtata aagactataa taaaaataat gatgatgtag taattttagg agtagcttca
    24601 cctaatttag gtagagaagg ttcaagggaa catgtagtta acttcttaaa agaacaaggt
    24661 tatacattcc ctgttgtact tgatgaagat ggagcattag catatcaata tggaattaat
    24721 gcttttccaa ctacatttat aattgacaag gaaggatatg taactcagta tattccagga
    24781 gctatggata aggcaactat ggcatcattt attgaaaatc agagaaataa ataaaagtat
    24841 ttaagtataa gtttataaat caatttaagg ttacaaaaaa gtgcctaatt gtaccaccta
    24901 aataatcttg ttatagtaaa agtataaaca atacaagaaa gggttgaatt ttatatgaaa
    24961 aaaacatttg atgctataat aataggattt ggaaaaggtg gaaaaacatt agcaggggat
    25021 ttggcaaaca ggggattaaa agtagcttta atagaaaagt caaacaagat gtatggtgga
    25081 acatgtgtaa atgtggcatg tataccaaca aaaagcttag aaaattcagc aaacagcgta
    25141 aaaacaaaga atataaattc ttgggatgaa gtacaagctg aatatgagaa agctatagat
    25201 aaaaaagaaa ctttaattac aaaactcaga gaagctaact ataataaatt aaattcaaat
    25261 gagaatgtaa ctatattcac aggaatggga actttcattg atgaaaaaac agttcaagtc
    25321 aaaactgaaa atgaaattta tgagttagta gcagataata tatttattaa tactggttca
    25381 agaccattta tacctaatat taagggaatt gaaaataaga atatagtata tgatagtgag
    25441 tctcttatga atctaagagt tttacctaaa aaaatgacaa ttataggagc tggatttata
    25501 ggtttagaat ttgctggtat ttatagttca tttggagcag aagttacaat attaaactct
    25561 aataatggca ttttaccaaa tgaagatgtt gaggattcag aagaaataat aaaattactt
    25621 gcaaagagaa atgtaaaaat tgttaataat gcaaatataa aagagattaa agaagtttct
    25681 gaattagcaa tagtagaata tgaagtagat ggtaaatcta aagaattaac aagtaatatg
    25741 atacttgtag ctacaggaag aaaagcaaac actgaagggc tagggctaga aaatgcaggt
    25801 atagaattaa atgaaagagg atttattaaa gtctcagaaa ctcttaagac taataaagag
    25861 catatatggg ctataggaga tataaatgga ggtccacaat ttacttatat ttcattggat
    25921 gattatcgca tagttattaa tcagttattt ggagataaga ctagaacaac taatgataga
    25981 aagaatatcc caaattctat atttataagt ccagcatttt caagagttgg tcttaatgtt
    26041 aagcaagcta aagaaaaggg atatgaagta ttagtggcaa agatgccagt agaagcaatt
    26101 ccaagagcta aacagattgg caaggcagat gggtttataa aaatagtgat agataaaaaa
    26161 tccaataaga tacttggagc tagtatgata tgtgaaaatt caagtgagat tatccatctt
    26221 attcaattag ctgtagattt agaagtagag tatacatatt taagagaccg tgtttatgca
    26281 catccaacta tgacagaagc tcttaatgat attctatctc ctaatatgat aaaagaagta
    26341 taacataagt ttaatatata aatctaaaat tatcattata agtagatttt agaaagaggc
    26401 tatctcaaaa aatagagata agtctctttt ttactgttta aataataaaa atatatttta
    26461 atggtattaa aaattatctt aaaaggtgaa ataatctgta tttaatgtag tacagttata
    26521 tctttaaagc aaggtggtga aatgatataa ataagatatc taaaagaggg tttgatgata
    26581 gtgataaaag atggttttca agtaaagaat taacaagact tataaaggct aaagaagaaa
    26641 tagaatggtt attaaatagg gattacaaaa tagacccagt cgttactttt gttggtgata
    26701 gatatcagtt ttctataaga caaagagatg cattaaaaag ggcagtctgt actgatgaaa
    26761 aaaatattat aagacaatca aagaggcttt ctctagataa aatcaaagaa gataccgtaa
    26821 atatagatgg ctttaatttg ataatatcca tagaggtagg attatctggt ggtactctag
    26881 taataggaag tgatggcaat ataagagatt tagcaggtct taggggaacc tataagatta
    26941 tagataaaac agaagaagct ttgaatctga taggtaaatt ttttaataaa tacaatgcac
    27001 agaatcttaa attttattta gatgctccag tttctaattc aggaaattta aagtatagga
    27061 tattagagca tgccaaaact tggggaattg aaactgaagt agaattagta aaaaatgcag
    27121 atgttgtatt ggaaaaatta gatagagtag ttagtagtga tgcagtcata gttgacaagt
    27181 gtataagtta ttttaatgtg gctagaggta taattgaaga gtatattaaa gaatgtaata
    27241 tcataaattt aaataaatag ataaatatag gtgagaatat ataagtatat gtagcaatat
    27301 tcttagtaat acaagtaaag tttgaaaata ggagaacgaa tacatatcga atttcataaa
    27361 atgttgtaaa aagacatatg agaggatgga tatgtgtgaa attaactaaa ctaaatatta
    27421 aaaaatatag agcacctata tataaatatg ctttagcaaa tataaatttg aggtctgcta
    27481 aatctaccaa ttcaagtatc ataacagtaa tacctcaggg agccaaaatg gaagtattgg
    27541 atgaggaaga tgactggatt aaggtgatgt acaattctca agaaggatat gtgtataagg
    27601 agttggtatc agtaagcgaa tatgcttgga gtaacttaaa cttaagagaa gataaatcta
    27661 caacttccaa tataattaca gtaattcctg aaaaatctag ggttgaagtc cttcaagtag
    27721 atggagattg gagtaaggtt gtatatgatg ataaaatagg atatgttttt aattattttt
    27781 tatcaattga tgggaataaa ccaaatgaat tagattataa gtatttttat actgacatga
    27841 ttaaatttgt taacgaaaat aatattaaaa gtactagcga ttatctaatt gtaacagacc
    27901 ttagaaataa atatacttat atttttaaga aagataatgg aggatgggga caactttaca
    27961 agtggcaatg tactataggc aagcctgaga ctccaactat aacaggtata ttttatataa
    28021 gtggaagaaa accttctttt ggaacggatg agtattcagt taagtatgct actagaatta
    28081 aaggtggata ttactatcat tctgtactat atgattcaac aggaagttat ataatagatg
    28141 gcagacttgg tgaagctctt agtcatggat gtataagatt aagtacggaa aatgcaaagt
    28201 ggatatatga taatatacca gatacaacaa cagttataat tcattaagaa aaattttgag
    28261 ttttttattg ggataatgat tcttaaatta ataggattat atattaactt ctcataaaga
    28321 gtactattta aaaagtgtaa taagagagtg ctattaacaa aacaaagata ttttgaggca
    28381 ctctcttata aatatacata attaagatat tttcataaac aattctataa tcttatcttt
    28441 atcaaagaaa acaggattag caccagcaca agcatctttc atagagtttt ctgcaagcaa
    28501 ttcaaaatta ggattatcaa cacctacatc ttttaaagat tttgggattc caacctcttc
    28561 agaaagagct tttatcttat ctattacaaa gtcaacacac tctttatctg atttattatt
    28621 tacatccatt ccaataactt cagctattgg tcggaatttg gcaggggctg atttagcatt
    28681 ttcctcctca actattggaa gtagcatggc attacatact ccatgaggta aatcatataa
    28741 acctcctaat tgatgagcca tagcatgtac atttccaaga cctgcattac taaaggcaat
    28801 tccatttaaa aaacaagcat aacacatttg ttctctagct tctatgtcat taccattttt
    28861 aacagctctt ggaaggtatt taaatatctg ctttatagca tataaggcag ttgaatctgt
    28921 aacatcataa gcaccattag ctactacagc ttctatagca tgagttagtg catccatacc
    28981 agttgctgct gttaaattag atggtttgct aatcattaat tctgggtcat ttactgtcat
    29041 tgtggctagt gaattggtat caaccattat catctttaca tgtctgtctt catcagttat
    29101 aacatagttt attgtaactt cagcagatgt accagcagta gtagttatag ctatgatagg
    29161 aagacatttt ttagaagttt tgttgatacc ttcatagtct ctaatatctc ctccattagt
    29221 ggctaatata gagatagctt taccacagtc ttgtggagaa ccacctccta tagttataac
    29281 gaagtcgcaa ttttctgatt ttaatatttt aagtccttta ttcacattag ttacagttgg
    29341 attttgttta acttcatcat aaacaacaaa gtctatatct atctgagata aaatatctgt
    29401 tacttttttt acagtaccat ttgaaactag aaatttatca ctaacaataa atgctttttt
    29461 agttcctaat gatttaattg aatctttagc ttcattaaga catcctttcc caagtaaatt
    29521 tattggtggt acataataaa tgctcataac taaaatctcc ttttattttc attgattttt
    29581 atgtaaaaat atatatctaa caattttcac taatttactc ataatatatc gtatcttaga
    29641 ttgagatagg gttgctggtt cttatataag aacttaattc gtaattacga ttatgattag
    29701 aatttaacat agtattttta tcatgtcaat aaaaatataa aaaatattat aaaaaaaaca
    29761 aagttactgt agttaaatca gcaactttgt ttttatagta taaatcaaat aaatacatta
    29821 gtttaaaaca aaatttttaa ttattatgtt ttgatatctt ccatatacag aatattaatc
    29881 taatttatta caatgtcttc attacgttct tccatcattg attgaatatt tttctgagca
    29941 tttaagagta atttttttat cagttctatt ttttcgtcat tagctctaaa taaaggcagt
    30001 gttacactaa cagcagctct tatacatcca ttttttctta ttggtacggc aagacatttt
    30061 aggtgttcca ttgattcctc acactctgaa gctatttgtg ttctttgaac ttcaagaagc
    30121 tggtcgtata aaacatcaaa atctgtaatt gatttttctg taaaaccttt tagaccatct
    30181 ggatataagc ttattagttt ttccttgtca aaatcacata aaagagcttt tccaagacct
    30241 gtacaattag caggtatttt ttttccaaca taagaaataa gtctaatcgg ttctggagaa
    30301 tctacttttc caatataaag aacttcatta ttgtcaagta taccaagctg acaagtttca
    30361 gaacaggaat taactatatt agtcatttcg tcaattatat agttaaaaat agttcttttt
    30421 tcaaaaaatg aagaccctaa tgtgtaagaa cgtatcccta tagaatattt ggatgtgttt
    30481 ttatcaatag taatgtattt tctagcatta agtgtatgaa ctataggaaa gatgctactt
    30541 tttggagcat tgataacatc tgctatttct gtaagagtat atccattttc ggattctgct
    30601 aatgcttcta aaatatctaa tatcctagct gttgggcgat gattatctga agtcataaat
    30661 ttccccctct ttttattaat ttaaagtatt agaatatgtt gattttagca cactatacga
    30721 tattttacaa tgtagaaaat aaatatgtaa atttatatat aaataagctc ttgatttaga
    30781 tacagataga tattttttta gactgtacat taaggaataa ctaatttcca aaatatacct
    30841 aaagaaagta agtgatattt agttatataa tttaagtaaa tatatgcaat agttattttt
    30901 atatgtaaat atcaaaatat tatgaactta tattttatct attttttaca ctgtataaaa
    30961 actttatagt tttgaatact atataatttt aaatacgctg tatttttgca tataaggaag
    31021 tcatttgata atatacaagg tattatcaga aagtttgaaa aaattttgac aaaaatttat
    31081 tttttttatt gactcataaa taggaaaatg ctatcattaa ttcaaagatt cgtaattaaa
    31141 aacttagttc ttaaatacga accgaaacgg ccgttagaat taaagctaaa aacttaataa
    31201 gagtaattaa atatcatgtt ttaggaggat taactttatg ataatggatt ttattaaaaa
    31261 aattcctgca ggtatgatga tagtgccaat gtttatagca gctttcatta ataccttttg
    31321 cccagatatt gtacaaatag gttcgtttac gacagcagta ttttcaagtg ttgggtctgc
    31381 aactataatt ggggttcaac tggtatgctt gggaactcag cttcaattta gagaaatgcc
    31441 aaaagtttta aagagaggtg gtatacttct tggttctaaa tttgctatag gtgctttgat
    31501 aggtatactt ataggaaagc tatttggaat ggatggtgtc cttggtctga caacattggc
    31561 tgttataagt gcagttacaa atagtaatgg tagtatatat ctttcattga tgacttcata
    31621 tggagatgaa acagattgtg caactatgag tttacttact ttaaatgatg gaccattttt
    31681 tacattaata gctcttggga cttcaggtct tgcaaatgta ccattgttgt cattattggc
    31741 tgcaatagtg ccaatacttg ttggtatgat aataggaaat tttgacaaaa aaatgaaaga
    31801 gtttttagag ccagggtgta atttactcgt accttttgta gggtttgcac ttggtagtag
    31861 cataaatctt gcaagtatac taaaaggagg tttatcagga gtattacttg gattaatatc
    31921 tgtatttgta ggaggtatat ttatagtatt ctgtgataaa tttataggaa aacgtccagg
    31981 atatgcagga tgggctgtag ctacaactgc tggaaatgca attgctgtac ctgctgctgt
    32041 tgcattagtt gacccatcat ggcaaccata tgttgcaaca gctacaacac aagtggcagc
    32101 cgcagtagtt gtcactgcaa tattagtacc tcttataact agttggtggg ctaagaagta
    32161 tggatgtcct aagttcccaa aacaaaatga ggatggtaca ataacagctt aatttatatt
    32221 acagtgagtt gttggtaaaa taataaattc tttaattaga ttttaggata ttaataaaat
    32281 tatattattt ataaaggaga gcaagaataa tgataaatgc agtgataatt gatgaaaaag
    32341 ataatgttgc agtagctatt gaagcaatag ctaaaggtag tgaaattagt tttaaattaa
    32401 aagacaaaac agtaaaaacg attacagcac tagatgatat aactatttat cataaattgg
    32461 ctataaaaga tatggccaaa ggtgataaag ttactaaata tggtgaacat ataggagaag
    32521 caaatcagga aataaaaagt ggccaacatg tacatattca taatgttaga agtgttagag
    32581 aggatttgga taaacaagtt atgactaata tataaaataa tatttataga gttataaaag
    32641 ttgtattcat tgcttttagt gtcaaatagt ttttaaatag gtttttagct gtttgattag
    32701 tgagtgtaat aaaaattata atatataaaa attatagaaa gtatatagac tattttagga
    32761 ggaaatcagt atgaaatttt atggatataa aagaccagat ggaagagttg gtataagaaa
    32821 ccacatatta atattgccta cgagtgtgtg tgcatcagat acaactagaa taatagcatc
    32881 acaagttcaa ggggcagtta cctttaataa tcagaatgga tgttcacaag tacattcaga
    32941 ccaacaatta actatggatg ttatggctgg ttatgcagca aatccaaatg tatatggtgt
    33001 aatagttgta tctttgggat gcgaaaattg ccaaaatgat ttggtagttg atgcaataaa
    33061 agagagaaca aataagccaa taaaaactct tgtaatacaa gaagaacatg gaactttaaa
    33121 aactatagaa aaagctgttc gttatgctag agaaatggca caagaagctt ctttgcttag
    33181 aaaagaagaa tttccaatat ctgaacttat actaggaact gaatgtggtg ggtctgaccc
    33241 aacaagtgga ttagcagcaa atccattaat aggtgaatta agtgataaac ttgtcgattt
    33301 aggagcaaca tcaattttaa gtgaaactac tgaatttata ggtgcagagc atatactagc
    33361 taggagagca gtaaatgaag aagtaaaaga aaaaatatta catatagtac atagatatga
    33421 aaattcatta aaattggttg gagaagaagt tagagaaggt aatccatctc ctggaaatat
    33481 agctggtggt ttaacaagtt tagaagaaaa atcacttggt tgtatacata aaggtggtca
    33541 tagacaaata agtgaagtat atgattatgc caaacaaatt gataagaaag gtcttgttat
    33601 aatggatacc cctggaaatg atgcttcatc tgttgctggt atggtagcag gaggagcaca
    33661 aatagtggta tttagtacag gaagaggaac accatcagga aatccaatag caccagtaat
    33721 aaaaataact ggaaataaaa taacttttgc aaatatggaa gataatatgg attttgatgc
    33781 tagtccagtt atctatggtc cacaaacaat ggaagaatta acagatgatt tgttaaatat
    33841 ggttgtagat gtagcaaatg gaaaacaatc aaaagcagag tcccttggat atactgaaat
    33901 ggcaatagct agagtatgca actatgtata atctttaagt aagaaaataa atacatagaa
    33961 ttttaataaa gggtgagatt atgaagtttg taagttttac tgaaggagaa aatgaatgta
    34021 aaagaactgg agttttttct aaagatgaat tatttattat agatgttaac tctttaaatc
    34081 tcagtagaaa ttttaaggat ttaaatgaat taattcaaaa tgtatctagt gaagatatta
    34141 ttaagttgaa aactattata aatgaaagta cattctataa ttatgatgtt tttaaaagag
    34201 agagatgtac ggtacatgtt cctatagaaa aaccaataca tgatatctta tgtgtgggag
    34261 tgaactataa agaccatctt gaagaaactc aaactcactt tgatgatagt tttgaagaac
    34321 cacaaaaaac ggtttatttt acaaaacgtg tgacaaaggc aataggtcca gaagatgaga
    34381 tagatggtca ttttgagata aataatcaac tagactatga agttgaactt ggagtagtaa
    34441 taggtaaaac aggtgttaat attagaaaag aagaggtaga agattatatc tttggttaca
    34501 ctgttataaa tgatatttct gctagaaagt tgcaaaaaga acatgttcaa tggtttagag
    34561 gaaaaggatt agatacattt acctctttag gtccatgtat tttacataaa agtgcagttc
    34621 cttttcctat aaaacttaaa gtatgtagta gggtaaatgg tgaagaaaga caaagttcta
    34681 atacaggatt attcatatca gacgtttcag acatagtttc agaactttca aaaggtatga
    34741 ccttagaggc tggagacatt atagctactg gaacaccttc tggagtaggg atgggatttt
    34801 cacctcctcg atatatgagt agtggagatg tagttgaatg tgagattgag agtattggaa
    34861 ttttaaaaaa ttacattaag taactgtttt aatataatta atattaaagc taaatctgat
    34921 gtattaatga acatattaaa ataaatttta ggagtttaaa ttatgaaagc agaatttttg
    34981 acaccagttg ttacaatatt tgatgaagaa ggaaatttag ataaagaagg taataaaaaa
    35041 gtgtatgacc atcttataga tggaggtgta gatggactag tcataatggg aagtactgga
    35101 gagttcttta atatgtctat ggatatgcaa aaagaactta tagatttagt aactagtcat
    35161 gtaaataaga gagtaaaagt gtttataggt acaagtcgta tgtgtataaa tgaatctata
    35221 gaactttcaa actatgcaca taatagtgga gcagatggtg ttatgataat aagcccttat
    35281 tatttctctc ttgatgatga tagtattgag ttattttata gtgaaatagc taagaataca
    35341 gaggctgaaa tatatttgta caattatcca gatagaactg gttatgattt aagtccagaa
    35401 cttacattaa gacttgcaag aaaacataaa aacatagttg gatataagga tacagtaact
    35461 ttgatgggac ataccagaga tttaataaat actatgaaaa tagagttccc agaatttaag
    35521 gtttatagtg gttatgatga aaactttata cataatctaa tgtctggggg agcaggttgt
    35581 ataggggggt tatcaaattt aattccagaa gtttgctcca aatgggctga agcttacaat
    35641 aatagagata tggagaaggt tatagaaatt caaaaatata ttaataaagc aatggatttt
    35701 tacttaataa ccaatccatt tataccagca atgaaaaaag ctatgaatat cagagggtta
    35761 caaataagtg attatatgac tgctccattt gtaaaaccaa atgaaaaaca agtatgtgaa
    35821 attaaaaaat tgatgaatga attaaatata tgttaaatca accttgcaaa gaggtcaaca
    35881 ataaattaca attatcttaa taaaaattaa attaaaataa tactagggta ctatattagt
    35941 ttaataggga aagtgatgaa aattcactac agcccccgct actgtatacg gatacgaaat
    36001 caaaatccac tgaaatttat aaaaattttg ggaagggtga tggaggaaaa gccgtgagtc
    36061 aggagacctg cccagtatta tataagttca atttagggtg gagattgtaa tttataataa
    36121 aatgaagtat caattcgttt ttgtaaagtt gatatatgaa cttctcctta ttaaattagg
    36181 agaagttttt tattttatta aaaggttata cttattaaag atgactttag gataacttta
    36241 ataagtatac tttaaaaagc atatattatt aaagtttttt agccactcat aaaaaataag
    36301 atattggagt gaaagagatg aaatttaaat caaatgtttt aaagcagttt tttttaattg
    36361 ctatggtaat ttttatggta ggaggtctta tagggtgtag taaaagtgac aaagagaata
    36421 aacaagctag tactggtaag aaattagaat taaaatatgc tagtggattt agtgttgaag
    36481 atttagaaga tggaattaaa aaagtaactg atggagataa tcgagaactg attttaatcc
    36541 caaagaagat taaaattcct gaaaaatata aaaatgctaa tatagttaga acgcctgtgg
    36601 acaatgtatt aatagcatct acaacacagg cttgttctct gagaacaata gatgaactag
    36661 atagtataaa agccgtaaca acagaagagc agtactggac tattaaagaa attaaagatt
    36721 taatgaaaga tggaaaaata cattacgttg gttcaaattt agcaccagat tatgaaaaaa
    36781 tagtagactt aaatcctgac ttaactatag tgagtagtgg tttatcagag gctgatacaa
    36841 aatttattga caaattaaaa gaattagggc ttaattatgt tgtagacaat gagtataaag
    36901 agcaaaatcc atttggaaga atggagtgga caagtttaat agctgcattt tatgataaag
    36961 aagatatggc tactagtgaa ctaaataaaa ctgtacaaaa ggtagaagaa gtaagtaaaa
    37021 aaataaaaaa caaagctaaa cctaaagttg tatgggcatc tgtatatgaa ggaagtgctt
    37081 atatagctcc taaagattca tatgtggata atatgataaa aatggctggt ggaataaatg
    37141 catgtgcttc aatagattca aatgaagggc gagtaagtat tgaacaattg catgaagttg
    37201 caaaagatgc agatatattt gtatactcat caagttcaga ttatgcacca aatttagatt
    37261 ctataaaatc tagtgcacct gtattggctg atttggatgt tgtaaaaaac gggaacctat
    37321 gggtgtttgc tccagattat tatcaatcag tagataagac ggacgaatta atagtagatt
    37381 tagttgagat gttccaccca ggtactacag gtgaaaaaat caaacattat ataaattatg
    37441 ataaatagta cagagaggac acaaaaagat aggttttata gattttagtt aatatagctt
    37501 tgctaagagg agtatacaaa tggattttat caataaaatg agaataagga atacaacaat
    37561 atttatagta ttaattataa gtatgatact tactttttta gtgtgtgtag catttggctc
    37621 tgtaaaaatt gaatttaaag aagtaataga tgttgtatta agaggtatgg ataatacaga
    37681 acattataaa ataatataca atataagaat ccctagagta cttgcaacca tggtaggtgg
    37741 agcatgccta gcagtatcag gtattttatt acagatattt tttaaaaacc caatagttga
    37801 accgtatata ttaggagtat cttcaggttc tactttatca gtagctctca tgattttggg
    37861 aggatacaca ttgggatttg agagtgtaaa ttcaatgagt atatttgtag cagcttttat
    37921 aggagcttta attgtaatgt ctatagtcat tttatttgca aataaggtaa agaatataac
    37981 aactctttta ataataggaa ttatgaccgg atatgtatgt agtggtataa caaatgtgtt
    38041 acaatcattt gcaaatagtg ataaattaaa agaatttact atgtggtcta tgggaagttt
    38101 ttctggattt acatgggaaa aggtagaaat acttataata gttggtatat taggtctttt
    38161 gatgactgta ttcataataa aacctttaaa tgctttttta ctaggagaag agtatgcaaa
    38221 aagtattggc ataaatataa gattttttag agttttgata gtatttatat ctagtatatt
    38281 agcagcaata gtatcagcat ttgcaggacc tatagggttt attggacttg cagtgccaca
    38341 aatttcaaaa atgatattta aaacatcaga taatagagtt ttgataccag tagtaatatt
    38401 tttaggcagt atagttacag ctctttgtga tttaatatca agagtaattt tatcaccagt
    38461 agaattacca ataagtacga taacatcttt attaggagct ccaattgtag taatgttatt
    38521 ggtgaaaagg aaggataggg cttagacatg ttgaaaacta ataatttaag tgtaggatac
    38581 aataacaaag ttgttataag taatataaat gtagaagtaa aaaatggaga aatactatgt
    38641 cttttgggaa gtaatggagc tggaaaaact accctattaa ggtccttatc taaacttata
    38701 tcaccaataa aaggtgaaat atatttgaat ggtgtaaaca taaactgtat atcaagaaaa
    38761 gcattatcaa aaaaaatggc tttagtactt acaaatagat tattaggtga tttaatgact
    38821 gtacaagata tagtcaatat aggaaggtat ccatatacag gattttttgg gagtctatct
    38881 aagaaagatt taataatggt agatgaagca ttggagtctg tagatgcctt acatttaaag
    38941 aaaagatatt ttgatgaact aagtgatgga gaaaaacaaa aggtgttggt tgcaagggct
    39001 cttgttcaag aaccagaaat aattatatta gatgagccta caactcactt ggatataaaa
    39061 catagattgg aactcataaa catactgaaa aaattaagta aagaaaagtc aatatcagta
    39121 atactttcat tgcatgaaat agacatagca ttaaaaagtt gtgataaagt tgctcttata
    39181 aaaaataata aagtcatagc ttatggtcag cctgaagatg tagtagatga ggatattata
    39241 aattcgcttt atgaattgga tgataaaaac tttaatagtc ttttaggttc agtagaaatt
    39301 agtaataaat ctaaaaatga agtttttata attggtggtg ggggtaaagc aacaccaatt
    39361 tatagagctt ttactaaaaa aggtataggt ctgtattctg gaataataca tgaaaatgat
    39421 attgattatg aaattggtag aactatgggg ataaagatgt ttacagaaaa tccatttgag
    39481 cctataagtg atgagagttt caatttggct attagaaatt taaatgattc caagattata
    39541 atagatacag gatttagtgt aggagagaca aataagagga atatagatat tataaaagag
    39601 gctttaaaat tggataaaaa agtttattct tttagaaata gagatgagag taagaagtat
    39661 tatgacagtt tggatagtaa gatagaacat atagataaag tttctcaaat aatcaatagt
    39721 gcagatataa ataatttatt ataatttatg aaataaaatg tacttatgtg ctatagaaaa
    39781 aagagtatag attataattt ttttgaaatt acaatctata ctcttttgtt attttgttta
    39841 tgtatttata tatttataaa actttagcat tttatagata accaatagct tcctctctag
    39901 ttaaaaaaaa gtgaatccct gtagtcgatt ctttccatct attttcatta aaatcttcag
    39961 ctacaatcgt ttctcctact ctatatataa aattttcatc agcatatgca cgagcacttt
    40021 taaaagattc tttaccatct atactagtaa ttgacagtac ttttgcctta tcacatctac
    40081 aagcgtttga tgtagcagac actctttttg cgtcgctggg tattaataat tgtaccattc
    40141 taaaattaaa acatttttta tagcctataa atgctcctgt ttcaggacaa tacaatttaa
    40201 aaaaacgggt actttcatct gatattactc catttaaagt agcatgttct aaatttgaat
    40261 tttctaaatt agctcctcta atatctgagt tagataagtc acaaaatcta aaacttgcac
    40321 cacttaagtc tgcatttttt aatatagaat tttttaatga acaatccgaa agataagaat
    40381 tattaaaaat agagttttct aaatctgctt tttctaaatt taaattgata aggtcagacc
    40441 acgaaaagtc aatattactt aagcagtatc ctcttaagtc catattttct aatcttaatt
    40501 cttttaaatc tgccttttct ccagcattat tgtttttaag ccataaataa tgtttctcaa
    40561 gtgttttttc taattcttgt ttagaaatag ttttcattaa aatcaccttc ataaatttat
    40621 ttttatatat gtagtagcaa aatagtcata tatttaatta tataacaata aataaaaaac
    40681 ttctaaataa tatataaaat atcatcttga aagtactttt ttcaatatat cagaatatat
    40741 ttttaagcta tttagagata atttaaattt ttaaacagga cataataagc ttgtattgtt
    40801 ttatatttga gttgataaaa atttctttaa ataaaaataa tgtcaattat aaagtaataa
    40861 aagtttagat ataaaaaaat ttgtgtatat actatatgta gtatataata gataaagcac
    40921 tgactatatg tagtgctttt gtttttgaaa aatacttatt gcatttctat aattatagat
    40981 taattttggg atttcaactg ataagtacca aaagaaataa taagcaaatt aagtgaaatt
    41041 atggcacaag attatgttaa aaggacggta aataatgaat tggatagagc ttaacaatca
    41101 agtgataatt aaaaatgaac aaggcaagta ccaattggaa aaggataagg aagccttaag
    41161 tagttacata gaagaattta tacagccaaa gttgagaaaa tttaataacc tagaagaaag
    41221 attgaagtat ttaatagatg aaggttatta ttcaaaagaa gtaataaatc agtatagcat
    41281 agatgttatt aaaaatatat atgatatgat tgataaacat aagtttgaat ttcaatcata
    41341 tatgagtgca aataagtttt atcaaaatta tgcattaaag agcaatgatg gaaaggaaat
    41401 attagaaaca tataatgata aagtgttaat tgtagctttg acactaggaa atggtgataa
    41461 agatttagct ttaaacttgg cagataaaat agtaaaacaa gaatttcaac cagctacacc
    41521 tactttttta aatgctggaa gaaaaagggc tggagaaatg gtatcatgtt ttttactatc
    41581 tgtagaagat agtacagaag gtatatcata tgctatatct tcatcaaatc acttatcaaa
    41641 gattggtgga ggagttgcac taaatttatc taaacttaga gcatctggcg aatctatcaa
    41701 agatatagaa ggtgcagctg gaggtgttgt tggagtagct aaaatgttag aacaatcatt
    41761 tagttacttt aatcaaatgg gagctagaca aggttctggt gcggtgtacc ttactgtatt
    41821 ccatcctgat tttgaattgt tgatggatac taaaaagata aatgcagatg aaaaaataag
    41881 gcttgctaca ttatcattag gagctataat accagataaa tttatggagt tggcagaaaa
    41941 aaatgaagta gcatatgcat tttatcctca tactgtgtat aagaaatatg gagtttctct
    42001 tgatgagata gaaatggatg agtggtatga taaattggtt aatgatagtg atataagaaa
    42061 aaaagaaata aatcctaggc agatgttgac aaaaatagca cagatgcaac aagaaagtgg
    42121 atatccatat gtagtgtaca tagatacagc taatagagaa catacattaa aagatgttgg
    42181 aattattaaa atgtctaact tatgttgtga gatatttcaa tatcaaacac cttcagaaat
    42241 agaggggtat ggaggaaaaa atgaatgggg acaagatata agttgtaacc taggttcttt
    42301 aaacatagct aatgtaatgg ataataaaac tatagaaagt acagttgaaa cagcaataag
    42361 agcactgtca tttgtagcag atagcacaga tataaaacca gtgccaacgg taagcaatag
    42421 taacagcaag tctcattcta taggattagg agctatgaat ttacatggat acttagtaag
    42481 agaaaatatt ttatatactt cagatgatgc tatagatttt tctaatgtat tttttgcaat
    42541 ggttagatac tattcaatta aagcttctat gaaaatagct atagaaagaa atcaaacttt
    42601 tgaaggattt gataaatcag aatatgttaa gggaagaaat agcaaggttt tatcaaaata
    42661 ctatgaacaa tcttatctac ctaagtcaga aaaggtaaga gcattatttg aagggattta
    42721 tataccaaca aaagaagact ggacaaaatt attggatgag gtaaaagaaa aagggatata
    42781 taatgcatat ttaatggcag tagcaccaac tcaaagcatt agttatgttc aaaatgctac
    42841 atcaagtata atgccaatta ctgagccagt agaagtaaga acatatggag actctactac
    42901 aatatatcca atgccatttt taacaaatga taatatgttg tattatcaat cagcatacag
    42961 gatggatatg agaaaggtca tagatttagt ggcaacagtt caaaaccatg ttgaccaagg
    43021 tatatcaaca acactgtttg ttacagatga aaagacaact agagatatag ctagacatta
    43081 catatatgcc tataaaaaag gtttgaaaag tttatattac acaagaacaa agatgacaag
    43141 agatactcat gagtgtctag tgtgttcagt atagggagag aaattatgac atttaattta
    43201 cataaaatac ataatgcagt taactggaat agagaagaag atggatttac acaagctttt
    43261 tgggaacaaa atgtaaaaca attttggctt cctgaagaaa tatctgtttc taaagacata
    43321 aaggtatgga atgaactaag taataaagaa aaggaattat ataaaaaagt attgggtggt
    43381 ttaacattac tggatacaaa acaggggaat aatggaatac catctatgat gagtttaaca
    43441 gaaaacctac aaagaaaagc tgtcttgtct tttatgggga ctatggaaga aatacatgca
    43501 aaaagttatt cttctatatt tatgactcta ctttctaatt tagaaataga tgaattattt
    43561 gaatggatag aaacagaacc aacattacaa agaaaggctg atttagtttt agctcaatac
    43621 gaaaatacta caaatcaaga gggattatac ctatcaatgg ttacaagtgt atttttagag
    43681 agtttcttgt tttattcagg attcttttat ccattgtatc tatctggtca aggaaagatg
    43741 gtagctagtg gagaaataat atcgcttatt cttagagatg agtctttaca tggtaagtat
    43801 ataggattgc tagcacaaga aatatacgat tcatttgata aaatggataa ggagatgtta
    43861 gaagagaaga tgtattctat actttatagc cttatggaga atgagataga gtatacaaat
    43921 gttatataca gagaaagtgg gcttgaaaaa gaggttgtga actttttaaa atacaatgca
    43981 aatagagctt tagaaaatct agggtttgag aagctatata ctgtagatgc tataaatcca
    44041 attgtattaa atggtcttag cactgaaacc aaaacacatg attttttttc aactaagggt
    44101 aatggatacc aaaaaggagt gtatgaggaa ttagaggatg aagattttat aatataattt
    44161 ataattatga cacactgttg tcacttttag cgtgataata tcaatgtata aaatatatat
    44221 ggaggtattt ttatgaaata tgaatggaga aaaagagata aagagttata tttacctaaa
    44281 aagaatcctg taatagttga aataccagaa cagaaattta tcatgttaaa agggagtgga
    44341 gacccaaatt ctaaagaatt tactgaagca ataggagtac tttattcttt ggcatatgca
    44401 ataaaaacca tgcctaaaaa aggaattgta ccagaagggt attttgacta tacggttttt
    44461 cctttagaag gtatatggga taagggagaa aaaagtaaag gcttagatgt acttattaaa
    44521 gaagatttaa tttacactat aatgatacgt cagccagatt ttgttacaca agacctgttg
    44581 gataaagcta ctgatatagt aaagaagaaa aaacctcata atcttcttga aaaagttaga
    44641 tttgggtcta ttaatgaagg gctatgtgtt caaatgcttc atataggttc atatgataat
    44701 gaaccagaaa gctttgacat tatgaacgaa ttttgcaaaa aaaataaact tataagaaaa
    44761 tcttacacac atcgtgaaat ttatataagt gatgctagaa aagtatcgcc tgaatcattg
    44821 aagacggttt tacgttttga agtagaaagg gaagtataaa tattttgaat aatttataag
    44881 agttataaaa agtgaagtct gttgagactt cattttttga tgcaatttta aaattaaatt
    44941 tgatgtttca taatatttta aaaactttct acttttatta gtgtgaataa ctgttgctat
    45001 taaataataa tactaattat ataagtatta ttatataata tttatagatt attatataaa
    45061 tagattatta gtaagatgta tgcattatta attaaaataa attacatata ctatttaata
    45121 tttcatttaa aatattaaaa aatgtagata aaaattgttt tattaagaaa aaattaatat
    45181 attgacaaaa tttaagtgct catttaaact attaattgat aataatattc aatattaaat
    45241 aataggaggc gttatgaata aatatcttct aataaatcca gtggcagaaa gaatgtatgg
    45301 agaaaagttt caccttatta aagcaaattt gataaaaaag gggtacataa taacagaatg
    45361 tgaaccacag ttagaatatg taaaaaagca gtacaaagag tatacaaaaa agactgaaaa
    45421 tacaatgttg gattgtagat gtccagaaag tataagtctt ttaaaaagaa ataatttgat
    45481 aaataatttt gaagtaccta tgatagaacc aatattagta aggacttgta gggttttata
    45541 cgataaatat ataaaaagta aagatgatat gttggtagta acctgtccat gtacacaatt
    45601 aagagacttt gcaagtgaaa agtttaagga taagggtaat gctatgtttt atacatggaa
    45661 agagtttgct gaacaagaag gtgtaaaatc acttggaaaa atagatgaat caccaattcc
    45721 attaggatat ttcaaagata cttttgaaaa agttcttgaa gtatcaagtg aagacgaaat
    45781 attaagtgaa atacaaaaaa taagaaatgg ttttgaagat aagtatgaca tagtagaaat
    45841 gttttattgt aaagatggtt gtaataatgg agatggtttg taaatggtca ataaatttaa
    45901 taataagttt ttaaggctag taaagagtgt tctgatattt tttataattc ttttattatg
    45961 gaaaattaca aattatcttg gtatttggag tgattatata ttaccatcac ctgaaaaggt
    46021 atatagtaca tttttaaata tgataagtga tggttcaata tttattaatg tatatgcaag
    46081 tatgaaaaga gttttgatag gttttgcaat aagtactgct ataggtgtgc ctttagggat
    46141 attctttgga atttatagtg gagtatacga atactttaaa tctctaataa attttttaag
    46201 gaatacacct ccccttgctt taataccaat gcttatatta tggtttggta taggagagga
    46261 atcaaaaatt ataattatag ttttagcatc ttttttccca atctttacaa gcacattgaa
    46321 agggattaaa aattgtgact caaaactgat tgaagtgggt agagtatttg agttttcaaa
    46381 gcttcagata atatttaaaa taataatacc aaatgccatt cttgatattg ctgttgggtt
    46441 aaagttagct cttggatata gctttagagc aattattggg gcagaacttg tagcagcttc
    46501 atctggtctt ggatacttga tatctgatgg aaaagaaatg tctagaacag atgttgttat
    46561 tgtagggata atcgtaattg gacttttagg aataattaca gattacatat tttcgattat
    46621 tgtgaagaag gtaagtaagg gaaagatggt ggaagcatat gaataattta gtatgtgact
    46681 ctggatatat aattagaaat ttatataaaa gttataaagt tgacaataaa gaacatgtag
    46741 ttcttagtga tatctcttta aacatagata gaaaccatat aacagtaatt ttaggtgaaa
    46801 gtggttgtgg aaagactacc ttgcttagag caattgcatc acttgaaggt ataaatagtg
    46861 gtgaaattag gtttattaat gataataaag agtatagacc taatgttggt tttgtttttc
    46921 aggagagtag attaatgcct tggttaaacg taagtgaaaa tatagctttt cataatcaaa
    46981 gaaaaaatac tattttaaac aaggtgctta gaaaatttaa acacaataaa agaattagga
    47041 gtaaaattat aaatgataat tttagaagct tagaaacaaa tgataatttg aacaaatcaa
    47101 ataaatataa taggaaaagt aatattgatg tagaaaaata tcttaagatg atgaacttgc
    47161 agaaatttaa aaactcttat ccaaatgaat tgtcaggagg tatggcgcag agagtaagca
    47221 tagctagagc tctttctttc aatccagata tgttgcttat ggacgagcct ttttcggcat
    47281 tagattattt tacaaggatt gatatgcaaa atgaagttat aagaatacat aagtcaacta
    47341 ataaaggcgt gatatttgta actcatgata ttgatgaagc gttaaagata ggcaagaaaa
    47401 tagttgtttt cacagacgaa agaaaagtaa aagaatttaa tatagaagat ggttataata
    47461 gagatttaac ttcagattac tatattaaat taaaaaaaga tattttaatg acaatgaagt
    47521 caaataaagg catttaaaga aattaataat attttaagga gtaaagtaaa tgaaattaaa
    47581 aaagctattg ataggtataa cgatattaac acttgcaaca gcatctttag ctggatgtgc
    47641 taaaaaaaat aatggagaaa aactttcaga aataaattta acttatgtaa aatcaccatt
    47701 aaatgttcct tctataattc agaaacagga tgatttattt ggaaaggaat ttaaaaagga
    47761 taatataaaa gttaacttcc acgaaattac tacaggtcca gagcaaacac aagctttagc
    47821 tgctggagaa atagacttct tacatgcact aggtggtaca tcagctttaa tagctgcatc
    47881 taatggagta gagttaaaga tattaaacac ttatagcagg tcaccaaaag gatttatgat
    47941 tttgactaat aataattcaa taaaatcagc agcagattta gtaggtaaga aggtggcagg
    48001 cccaaaaggg actatattac atcaggtatt gatttcagca cttgataaag aaggattaag
    48061 tatggatgat gtggaatttg ttaatatggg tattccagag gcatcagcag ctctttctga
    48121 tggcagcgta gatgctgcat tgattgctgg gccagcagct cttaaagcta tgaagtcagg
    48181 tagtaaactt gtagcaaatg gtgaaggttt agtagatggt ataatagtaa ctgctgttag
    48241 cacagacttt gcagagaaac atccagaaat agttgaaaga tttatgaagg ttgaaaagga
    48301 aactttagaa tatgtaaata ataattttga tgaagctatg gaaaaagtag ctaaagaagt
    48361 tgatttaagt cttgaagaaa ctaaagaatt atatgcttgg tatgatttta gtttagatat
    48421 aacagataaa gacatatctt cgcttgaaga tacacaagac ttcttaataa aaaataagtt
    48481 acaagagaaa aaagtgaaca taaaagaatt aatctataat gctaagtaga aactatgata
    48541 aaataatact aagtaagaaa tataataaaa gtttaagtta ccttattaag gtaacttttt
    48601 ctattttgaa ttagtaattt caatttattt tagaatgatt agttgataat aatgattaat
    48661 taatcataaa aagatacttt tttatagagt tttattaaga tgtctaataa tatggttata
    48721 cttatgaagt cagtaattgt gaagttagta atatgattaa atttatatat tgtaaaaaga
    48781 ttataatata ttaaaattgg actgttatat gatgagtaaa taggtatatt aggaggaatt
    48841 atatgagtta taaagtatat attgtggaag atgacatatc aataagtaca ttacttaaag
    48901 attatattga gaaatatgga tttgaagtga ttgttgaaga gaactttgat gatataatga
    48961 ttacatttga aagttttaag ccacacttag ttctattaga tgtaaattta cctaaatttg
    49021 atggtttcta ctggtgtaga tgtattaggc aacagtcgaa tttacctata atttttatat
    49081 cagctagaga tggtaatgta gaccaaatta gagctttaga aagtggagca gatgattata
    49141 taacaaaacc tttttactat gatgtagtaa tggcaaaaat aaagagtcat ataagaaggg
    49201 tatatggtga atattcacct aaaatagacg aaagaatagt ggagctagat ggattaaaat
    49261 tttatccaga aaggttagaa ctagaattaa atggtgagaa tctaattata actaaaaaag
    49321 aaggtatact gattgaatgt cttatcaaga gatacccaaa agtagtaagt agagattatc
    49381 ttttagaaaa gatatgggat gatattgagt ttgtagagga aaatacttta aatgtaaatg
    49441 ttagcaggat aaggaaaaga tttgaggaat taggtataga taatgctgtt cagactgtcc
    49501 gagggttagg atataaatta aataagaatt ggtaaggaga aagtatgaag ttatttttaa
    49561 aagattataa aggttatatt tttatatatt atataggcat agttatgaca attatttact
    49621 gtaatcttat gaagtttatt agttttggag agagtttata tattctttta tttagttctt
    49681 ttatattgtt atgtttttta atatataagt attataaaaa tagagaagta tataatctgt
    49741 ttgaaaaagg agtacattct ttggaggagt catttttgta tttaggaagc tcattcttgg
    49801 ggagaaatat atcagttatt ttaaaacaac aacataaatt gtatcaatca atgatacaag
    49861 agcataaaaa gatacatagt gaacatttaa ctttcatcaa ccaatggatt catcagatga
    49921 aaacaccaat atcagttata agccttcagc tccaagatta tgagggagaa gaagtaactg
    49981 aaaatataag aaaagaaata gatagattga ataaagggtt agatatggct atgcattttg
    50041 caagggcaga taattttcag aaagacttta tagttgaaaa agccaaatta aatgaaattg
    50101 tatctagtat tgtaaatgaa gaaaaaaggt tatttataaa aagtggaatg attcctaaga
    50161 ttcaagtaga caagtttact tatgtttata cagatgtaaa atggatgaaa tttataatag
    50221 gtcaattaat tacaaatgga gtgaaatatt ctaaagatta tagtaactac ctaactataa
    50281 aatctgaaga aaataataaa tatgtaattt taagtataat agatgaagga attggaattg
    50341 tttctaaaga tttaaaaagg gtatttgccc cattttttac aggagaaaat ggtcgtaagt
    50401 ttggagaatc tacaggtatg ggtctttatc tagtaaaaaa ggtatgtgat gatttaggtc
    50461 ataaagtaag tataaaatca gaagtaggaa aaggtacaga agtttcaatc tactttaata
    50521 aaggtgtaaa tagtttgata aagatgtaaa ttatctgtta caatagggtt tttagttaat
    50581 tgtacttttt tattatacaa tttattaaat gaaatattca tagttaaata atcaaaattt
    50641 aagagagttt atttgcaaac cttacataga tgtaaggttt gtgtaatgtt tgcagatagt
    50701 taaattttct aatctaaatt acaattaata taagaaataa cataagagaa ataacataaa
    50761 aaaagaaatt ttgtaaaaaa ggaaggatgt ttattgatga gtttagatgt tatttttata
    50821 ttgaaatcag tcataatagc tatagtagag gggcttacag aatttattcc agtttcatct
    50881 acaggtcata tgattttggt tggtaattta atagatttta aggggcaatt tgctgaaatg
    50941 tttgaggttg taatacaact tggggctata ttagcagtag tagtacttta ttggaaaaag
    51001 ataaaagata gcgttataga attttttaaa tttatattta ctggtggaaa agaaggaaag
    51061 attggtttta gatttggaat gaatgtaatt ataggttgta taccatttgc gattatagga
    51121 gttctatttt acgataatat aaaatcattg tttaatttac aatctgtaat tataggattt
    51181 atagtgggtg ggattttatt attagtagta gaaactttgt ttagaaaaaa gaatcattcc
    51241 acagataata tagataaaat tactccaata caagctttaa aggttgggac attacaagtt
    51301 ttgtctgcat ggccaggtat gtcaaggagt gcatctacta ttatgggtgg atggatagca
    51361 ggacttaatt ctcctacagc agctgagttt tctttctttt tagcagtacc agctatggtg
    51421 gcttcttcag gaaaagattt atttgaattt gattattcaa taatgacacc aacattgtgg
    51481 attgctttgg tagttgggtt tatagtagct tttattgtat caataatagt tatggaaaaa
    51541 ttcgtgaatt ttttaaagaa aaaaccaatg agagtgtttg ctgtatacag aataatcatg
    51601 ggtgtagtac ttgcagtatt agcttttact aacataatta gtgtatagaa aaaatagatt
    51661 tattatctat aaaaattaaa ctaagataaa ttataattaa caattatata tatgttattt
    51721 caaaaattaa attaggaagg atagttaaat aatgaaaatt ttaactgtaa ataatttaag
    51781 taaagtatat ggtaaaaaaa taattttcaa cgcattaaat gacataaatt ttagtataga
    51841 agatggagaa tttgtaggaa ttatgggtcc atctggtagt ggaaaaacta ctcttttaaa
    51901 tatgatttct actattgaca agccaactac aggaactatg gaattaaagg gcaagaatcc
    51961 tttattgtta agaggtgagg aacttgcatt atttagaaga agagagttag gttttgtatt
    52021 tcaggatttt aatttattgg atacattaac tataggagaa aatatagtat tgccattgac
    52081 attagataag gtcagtgtaa aagagcaaga tgagagattg aatgaagtat ctacaatatt
    52141 aggtataaaa gatttattag gaaaaagaac ttttgaagta tcaggtggtc aagctcagag
    52201 gactgctatt gctagagcat tgattaacaa tccatcaata cttttagcag atgaaccaac
    52261 aggtaattta gattcaaagt catcaaaggt tgtaatggag ctatttcaaa agataaataa
    52321 agaaaataaa gttactacta tgatggtaac tcatgaccca ttagcagcga gctactgtag
    52381 tagaatctta ttcataaaag atgggtctat atataatgaa atatataagg gtagtagtag
    52441 agagcagttt tatcaagaga taatggatgt acttacatta ttgggaggcg ataactaatg
    52501 aatataaaac agtttgctat taacaatatt tcaagaaata ttaaagcgta tttaggatac
    52561 ttagcaagta ttgttatatc atcttcactg ctattttctt ttattatgtt tacaagtcat
    52621 ccagatttag atgtatctca atttcctgat tatttaaaag aaggtctcaa gatgagtaag
    52681 ataattgcat atctattctt attcttcttt gtgttttatt cagttagtgt gtttcttaaa
    52741 agtagatata aagaatttgg aatactttat attacaggta tatcaaagcg ccaagtaatg
    52801 aaattaatct ttatagaaaa tatgataata aatatagtat cttctgtaat tggaataata
    52861 ataggcttaa tctttgcaaa gatattttta gtggttatgt ctactttttt agaattatca
    52921 ccattaaaat tctatatacc atttaatgcg atattgtcta ctttaatcta ttttatgatt
    52981 ttagctgtat taacatcaat atttacttct tttatagtta aagaaaatca ggtgttgaag
    53041 ttacttaaag gtacaaaaac tccaaaacca gagcctaaaa catcactaat gcttgctata
    53101 ttaagtattt gtttgtttat aatagcgtat tataatgcta ttacctcaac cgaccaatat
    53161 acaacatatc tgcgcttagt tccagttaca tcccttacta tagtagcaac ttacttgttc
    53221 ttttctcaat ttagtgtatt ttttatgaag aagctaaaat taaacaagag attttataga
    53281 aaaaatacaa atatgctttg gatttcgaac ttgatttata aggtaaagga taatgctaga
    53341 atatttttct tgataactat aacttctgca gtggcattta ctgctatagg tacagtttat
    53401 tccttttgga aagatgtaga gcgtcaaatt aatttaatat atcctaacac aatatattat
    53461 tcaacaatga cattgcataa tgaccctaaa aagcctgata gcaaagaaaa agacaaggaa
    53521 agaatgatgt ttatagaaaa taatctaaaa aaagagaatg tagactatac aaggattaat
    53581 ggtgaattta aaactgtatt tcccaagaaa agtgatttta atgtcagaat tatgaaagaa
    53641 tctaagtact tagaaattac agaaactata ggggttaagc ctataagttt tgaagataat
    53701 gaatgtatat cattattatc atcaagttta ccaggaaata agaacgtcaa agaaaatatt
    53761 attgtaggga atagaggttt aaaggtggca aaacaagtgg aagaatgtgt tatgccagcg
    53821 tattacaaaa atatgtatgt ggtaaaggat aatttttatg atagtataga atcaaaattt
    53881 atagtggata gatttactgc atttgaagta gaggattcaa gtaaaactat agagatatgc
    53941 agagaatttg aaaataaatt taataatgag tcagggatgc aaccatattt gtttttctct
    54001 aaagaattaa tgataggaac tgggaaatta atgtattcta catttatatt tttagcaata
    54061 tttataggtt taattttctt tgttactaca agtagttttt tatataataa attttatatg
    54121 gattgccaag ttgataagaa aaagtatgaa cagttaaata aattgggtat gacatataat
    54181 gagattaaaa aagcttcaac aattgagatt ggaatagtat ttttgtttcc ttatgtagtg
    54241 gctgttatac attcaatatt tgcacttact gcactgaaaa attcttttga tatagaagta
    54301 gcatcatcag ctgttttggt aatgggaagc ttgttcttgg ttcaaatagt ttatttttta
    54361 attgtaagaa ataattattt aaaagagata aggttaaatt tagtcaattt ttagttacta
    54421 ttattaaatg ataataaaaa gggtttagaa ttaattaata ttactggaat tatagatgtt
    54481 tattttttca gtaatatttt ttattgtatt aactattaaa attttgtaca aatataaaat
    54541 ataatatggt aaatgtcaaa attataaaaa aattctactt atataaaata taaagaggtt
    54601 atatgtacat atgtgtagaa ataaataata aaaatatcaa ttaatgttat tagggggggt
    54661 tactcattag taaattagct aatacactta gaatgatgat attaattcaa agcagaggca
    54721 aaatgaaatg caaagaatta tcagaagagt tggaagtaag tgaaaggcaa ataaaaagtt
    54781 acaagatgta tttagagcaa gctggtatat ttataaattc aacacctggg atttatggtg
    54841 gttatgaaat agataaatgt aatagcatct cattaattaa attattagat agtgaagttt
    54901 caattctaga tatgataaat tcacagttag agtataataa tgatatttac aaaaatgaat
    54961 ttaataatat tgtagaaaaa ataaaagcag tattaaatac aggagaaaaa agcgatacat
    55021 atatggatta ttttacagtt caagcacaac gtaattgtga ttatgagtct gaaaaaaata
    55081 agtgtaatga aataattaga gcatatacca caaaacacaa attttggata gaatattatt
    55141 cattaaattc aggaaatagt gaaagaattg ttcatccata tggtttattt aattataaat
    55201 cagatactta tatggtagct ttttgtgaaa aaagatttaa gtttatagac tttaaattat
    55261 gtaggattaa agattataag gttttagaag aaaaatataa tgtagataaa agttttagtt
    55321 gggatgaata tagtaaaaat agtataggaa tttataaggg agaagaaatt aatgttgtta
    55381 taaaaattag tcatccattt tcaacaatta taaaggagaa agtttgggtt aataatcaac
    55441 aaatcataga atatgatgat aaatctataa tgtttaaagc taaaatgaga ggttatgagg
    55501 agataaaaag ttggatttta agtatgggag cttatgttga ggttgtagaa ccagatagac
    55561 ttagaaatga tatattgtta gagattgaaa aaatgaaaaa aatttactga ttttttcaaa
    55621 taatttatac ttggaccaat atacttcacg gtctagtgtt aatatattaa ttgagagagg
    55681 tgatattatg aaaatgaaaa ttgaatttag tacaggttgt ataccaatat cttataattc
    55741 gctctttatg agtattataa aagaagcaat aagaaaatct aatgaagatt actataaaaa
    55801 catgtactat tataaagaaa agaataataa aaaaactaaa aattttacat tttcggttta
    55861 tataaaaaag tatagtattg aaggtgacaa ttttattata gaagataaag taatattaaa
    55921 tataagtact ccagatttag aattgggttt tcatatatac aatgggttaa tgacttctaa
    55981 aaaatgttta tataaagact acgaacttac aagaattaga atcgatttat caagagaaaa
    56041 gaaggtaaca gaagaaaggg tactatttaa tgcattgtct ccaatctgtg taaagtctaa
    56101 agaaggaaaa ttcttggaga taactgatga tagatacata gaagaactaa actatataac
    56161 taatgaagtg gttaaaaatt atagggggaa tggattaaaa agaaagttag aatttgaaaa
    56221 tataggtctc aaaaaggtag tagttaaaga gagtttaaga gaatttaaaa aaataacagg
    56281 taaagagtat caatatatta atggttacaa aggtaaattt atattgaaag gtgatattga
    56341 tgatttaaat cttatctaca atctaggaat tggttttaga cgtgctcagg gatttggaga
    56401 tgtagatatt ttagaatgga ggtgagataa atgaagttaa gagtttatag aggagattgg
    56461 ttttttaata tgggtatagt tggattttta aatataataa agaaagcaga taaacaagct
    56521 gaaatattta ttatggaaga ttatatcgaa tttgatagct tatttcttga aaactttcat
    56581 gagtattatt ttaattactt tatggatgaa tatgatgtat caaaaagaat taaaaaaaat
    56641 attgattaca gtataaattt tattaaatct aagcctgata gaatcaaaga tggaattaag
    56701 aaaattaaag atagtgtgaa acaacaaaat gataagatta aaaaatttga tgaagaaaaa
    56761 tttaacatga taaaagagaa gctagatagt atgtctaaga taaaaagtta tgatgaattt
    56821 gatagtttag aagctttagt agatgagact atagatatat ttaaaataaa atcaataaat
    56881 gacaggctta cagcaaatct ttataaatat gtagttcaag ataattattt tggacaagtt
    56941 agttttttta atgttgctaa ggcgaaatta gatttagatg gattaaaaca ggtaatgttt
    57001 aatgattatt taagacaaat tatatatttt ggagagttag aagatttatt agaagagaat
    57061 gactatgaca agttgaaaaa ctatttaaat gatagattaa atagtatagc taaggatata
    57121 aatgaaaaaa aagttagtaa gtctagtata aatactatag aaaaaattat gaaggaaata
    57181 aataaaaact ttataaagaa aaataaaagc atagaagata taaaaaagta tatggatagt
    57241 ttagaagtat gtgaaatgtg tggtttatat aagggaatat tagatgaata ctcagaaagt
    57301 aattttgctc cacttggagt aagcaccaat aatgctagga atatgttttg gaatcaggcg
    57361 tatgtaccat caatatgtga tatttgtaag ctaatattgt tctgtactcc agcaggggct
    57421 acttatacaa gaaagaatta tttaattaat gaagaaaatg agttttattt atttgttaac
    57481 atggatactt gtataaatga gctttttgaa agaaataata gtttaaaagc tcaaaaaagt
    57541 gagtattcag attccaaaga tgaaaatcct tttaatcagc ttataaaaag tatagtagaa
    57601 gaaaatacat taaaaagtga atggcaactt cgtaatatac tttttgtgga atttaaagca
    57661 agtatagatt ctaaaaaatg taaaataaat tattttaata ttccaactta tttagcaaag
    57721 ttttttgtaa aagaaaataa aaaaatacaa agtatatatg attataaact taaatcaaat
    57781 gtgttagatt taattttaaa aagtaaagac ttaaaacatt taattaataa cactttaagg
    57841 aatatagtta agagtaattt agaaagcaat aataaatcaa acatatcagg gttatcttgt
    57901 ttcaatgttg ttcaattaag aacaatatta aataactata agagaggagt gtataaaatg
    57961 gactataaaa agttgagaaa gatttatgag tcaggttgtg aaatacatga ttattatatt
    58021 gataagaatg ctaaaaataa aatagaagga ataacatata aaattttaaa tttaattaag
    58081 gttggtaata aaaatgattt tatgcaaaca attttaagaa ttttttcacc aagtgaaaaa
    58141 acaccaccag aagaaatttt acagatattt gttgaagaag atttagattt tgaatctgta
    58201 gggtatgcat ttgtaacagg attaatttct ggaaaatatg aaggaaaaga taaactacca
    58261 aacgaaaagg aggaaaaata agatgaaaag agggttaaca tttacagtaa tagcacaggc
    58321 tcaaagttta aactatgggg aagggatagg taatatatca gaattaaaaa aattaagtag
    58381 agatgatgga aatatatata catttgcatc tcgccagtgt ttaagatatg acatagtacg
    58441 attagcagca gaattgttta attggaattt acaggttgtc gataaagaaa aaggcactat
    58501 tcaatttaaa gacaatataa gtataagaga atcagaagaa atggatttat ttggatatat
    58561 gaaaacaaat aaaaaagatg agaaagataa aaaaggaggt tctttgacta gagaagctac
    58621 tgtaagatta agtaatgcaa tttcccttga gccatataga agtgacatgg actttttaaa
    58681 taataaagga ttagcagata gaataggaga acatcctaat cttgctaaca tagagcaaca
    58741 tttaagttat tatacatata cagtgactat agatttatct aaaataggta aggatggaga
    58801 tatagaactt gataataaag agaaatgtag aagagtagta gaatttttag aaataataaa
    58861 agtattgaat agaaatatta gaggtagaca agaaaattta tctcctctat ttgtagtagg
    58921 aggagtatat gaaatagcaa atccattttt cttgggtaga attaaattaa aaggagataa
    58981 aaatggattt aaaataaata agcaagctat agaagaagta attcaaggta cttttttagg
    59041 aaaagattta aaagaattta cctatgttgg aatggtagat ggggtattta taaataaaga
    59101 agaatttaag ggattgtttg aagataattt tttaagtgta gataaatttt ttggacaact
    59161 agttaaagaa gtaaaggaat attatggggt gaattaatat gaaggttttg aaattagatt
    59221 tatttcaaga aactgcatgc tacaaaaaac catttgctat gaagattaca gagacatatc
    59281 cactgcctcc atattctaca ataaatggat taattcacaa aatattaaat gctacagaat
    59341 atataccatt taatataagt gtacagggaa catatgaaag tatatttaat aattaccaga
    59401 caacatattt ttataaaaaa gatagtatta catctatgcc aatgaatagt catatgctat
    59461 tgaatgtaaa tttgataatt catataggtg gggattttga tttattggaa gaaatatatg
    59521 atagtttatt aaattatgac gagcacttat cattaggtag aaaagaagat ttagtaagaa
    59581 ttaatgatat tagatttgta gaagtcaata aatttgaagt agatgaggat atacaattag
    59641 atgattatga aaattataag ttatcagaat gtaatataag aatgcctata tatataccaa
    59701 aaacaagttt acaagataca gatatagatg gtataagtta cagactcaat aattactatg
    59761 ataataatgc tgtggaagat aaaaaaaggg tttggaataa ggtagatagt tattatgttg
    59821 aggatggaaa tactatatca attggagata tattattaga taatgaagga gatttattat
    59881 attttaataa tataaattag gagggagatt atgttatatg ctaaatctaa tccagtggaa
    59941 acacttagag aacatactga tgaactttta aaacaaatga atgtattaag agaaagttat
    60001 ggaaaaaata taaatagctt agattttcta gaagaggaga tattttggca attacttgac
    60061 tttgttatag aatttcatga tattggaaaa gcattttcac cgtttcaaga gttaataaaa
    60121 agcagaatgg atactaaaat aaatgaacct aaaatagtaa cttatttaga aaataatgta
    60181 ggccataatt atctttctcc tgcatttatt gattatagtt atatagacag gaaaaaaaat
    60241 aaagaactta gagcagtatt aaatcaagtt attgtatatc atcatgaaag agatatcttt
    60301 atagataaag attttaaaaa tttaatacaa aaaatattag atgaagattt aataaataaa
    60361 gtttatgaac tacagcatga atttaaagtt agatatccaa taaaaacaga aaaattgagt
    60421 aaagtatatc tacaaagtgt agaaaaaaga atagataaaa atcacaagta ctataattta
    60481 tatattatgt taaaaggaat actacataga ctagaccata gtgcttctgc tcatgaagtt
    60541 gtggaatgca ataatgttat aaatatagga gaacagacag aaaattattt aatgaaagag
    60601 tttggtagtt tgagagaggc tcaatcattt gctaaatcta atagaaataa gaatataata
    60661 ctgattgcat ctacaggaat gggaaaaaca gaaactgcct taatttggat agataaagac
    60721 aaggcatttt ttacacttcc attaagagta agtataaatg cattatttga tagagcaaaa
    60781 aatatagttg gtgttggaga atcaaatgat acattcttag gtttgttaca ttcaacagca
    60841 atagattatc tagaagaaag taatcaagaa aattcaagtg agattgtaga tttagcaaag
    60901 ttattatctt gcaaactgac attttctaca atagaccaaa tatttaaatt tccttttttg
    60961 tatagagggt atgaaaaagt gtactcaaca ttagcatatt caaaagtagt aatagatgag
    61021 atacaagcat attcaccaga aatagcagct gtattggtaa aaggtataga aatgatacat
    61081 aagataggtg gcagatttat gataatgaca gctactatgc caaccatata tatagatgaa
    61141 ttaaaaaaaa gaggtgtaat gaatagtaac ttagctgaat tgacatgtaa tacagaaaaa
    61201 ataagacatt gtgtttctat tgtagaaaat tcaatagatg aaaacttagg taaaataata
    61261 caaagtggaa tgaataaaaa agttcttgta atagtaaata cagttaaaag tgctgtagaa
    61321 aaatatgagt taatagaaga aatagttaaa ccaaaaggaa tagatgtcaa cttaaatctt
    61381 ttacattcta tgtatataca agaagataga gcaaaattag aaaaatatat aaaagaattt
    61441 gccaatagtg atagaaatgg aatttggatt acaacacaat tagtagaggc atctcttgat
    61501 attgattttg atgagcttca tacagaaaat tcaacacttg acagtctatt tcaacgattt
    61561 ggtagatgtt atagaagtcg tgagtatgaa gaaaatagcc caaatatatt tatatataca
    61621 gaaaaagcta caggaatagg tagtatttat gataaggata ttgtagaaaa aggacttgag
    61681 ctactgaaaa cttttataaa tggaaaagaa tgtgtgaaga tgaaagaaaa atataaggta
    61741 gaaatggtta agatactata ctctaaagaa agtctagaag gtacagcttt tgaaaagaga
    61801 tttaccagtg ctttaaatat tttagatact ataacgccat atagtttagg ttctaaagat
    61861 gcacaaaata tacttagaaa tattgaagga tatacagtaa ttccagagga tatatataat
    61921 aaaattgaag aaactttaat caaagattat gaagagttgg gacaagagct tataaatgca
    61981 tatagtaatg atgatagaca attgataaat aaaataaagt ctaagagaaa aaaagcaaga
    62041 agagagataa ttaaaaaaac tgtaaattta ccaatatata aagctaaaca aaatgtaatt
    62101 gacatacagg tgaaaggtct tgaagattta aaaatacttt tatataaata tgatatatac
    62161 gaaaataagc atacaaaaca gatatttggt aaaggtgtgc ttataagtaa tgaaatagac
    62221 caatttattt gatttttata ttaacaatgt ggctaaaatt tactaaagaa ggtgattttg
    62281 tgccaataga tttagaagta ttaaaagttc aaggtgtaaa aataaattat tattatgtat
    62341 gtaaaagaaa actatggcta ttttctaaag gaataaccat ggaacaaaat agtagtagag
    62401 tattgtctgg gaagatagta catgaagatt catataaaag aatgaaaaat aaagaaatat
    62461 tgattgatga tatcttgaag ctagatataa taaaggatga gtatgtaaaa gaagtaaaaa
    62521 taagttcaaa gatgaaagaa gcagatgaaa tgcagttata ctattactta tactatttaa
    62581 agaatagtat gggtatagag aaaaaaggta ctataaatta tgttaaggaa aagaaacaag
    62641 aagaattgat attgacagaa gaaaaagaaa gaattattga aaacacactt ataaatataa
    62701 atgaaataaa tatgcagtta tctcctccca aaattgagaa aaaacattat tgtacaaaat
    62761 gtgcttatta tgaattttgt tttgtgaagg aggagtaaca atgtataaag actattatat
    62821 tataagtaat ggggatataa aaaggaaaga aaatacgatt tactattaca atttagaagg
    62881 tgagaaaaaa atattaccag tagaacaagt tgatgatatt catatatatg gagaagtaga
    62941 tttaaataca aaacttataa attacataag caaatatggg gtgatgcttc atttctacaa
    63001 ttactatgga tattattcag gtacatatta tccaaggaag aaaaatgtat caggattcag
    63061 tttagtatgt caatcagcct gctatttaga taaaaatgaa agattatact tagcaaaatc
    63121 ctttgtggaa agtgcatcat accatatttt aagaaatatg agatattaca aagttgatga
    63181 aagtttaatt gatactataa aggatgaact aaatgatttg aatgatgtca aagaaatatc
    63241 agaacttatg ggtaaagaag gcagaataag aaaaacatac tataaatcat ttaatcaaat
    63301 attaaaagat gattttgaat tttataaaag agaaaaaaga cctcccaaag acccagtaaa
    63361 tgctcttatg tcttttggaa atagcataat gtatacgaat gttttaagtg agatatataa
    63421 gacacaactt gaccctacaa taagcttttt acatgaacca tcaacaaaga gattttcttt
    63481 aagtttagat attgcagaaa tttttaagcc aattataatt gacacaataa tttttagcct
    63541 gattaataat aaaagaatta ataagaatga ttttgaatat caagacaaaa tttgttattt
    63601 aagtgaaaaa ggaaagaaga aatttttgca agaatttgaa aataagatgc agacaactat
    63661 aaaacataga aatctaaata gaaaagtttc atatagaatg tttataaggt tagagtgtta
    63721 taaattaatt aaacatttta taaatgatga aaggtacaaa gttttaaagg tgtggtggta
    63781 agtatgtttg ttattgttac ttatgatatt gttgaagcaa ggtcgttaaa tagaattaga
    63841 aggatactta gaaaatattt gacttggacg caaaattctg tttttgaagg caatattact
    63901 gaaggaaagt tacataaatg tatttctgaa atagaaaata ttattgataa tagcgaggat
    63961 tcaatctatg tttatgagat aaaaaatcct aattcaatta aaaagaaatg ttatgggatt
    64021 gataagtatt ctgatgaaat gtttatatag gtttgcagtg agcgatattt atgctaaaat
    64081 aggtgttaac agttggaata taagggattg aaggtgtatg ataattgtta tcaattgcac
    64141 tactgctcgc tcactgcaaa ttttgatgtt tttattgaat tataattgct tgattgaagt
    64201 gtttgcaatg tattcaaata tacctatttt ggggttttat attaactaag tggtatgtaa
    64261 ataatttttt cggatattta ataatttatt ttaaatttag ttttatatta actaagtggt
    64321 atgtaaatct caacagtatc tacaagaact tctatatctt ctaagtttta tattaactaa
    64381 gtggtatgta aattaattta gggtaacttt tatattattt tcttctatcg ttttatatta
    64441 actaagtggt atgtaaattt ggttgatata gatattagtc ctattatttc tgcttgtttt
    64501 atattaacta agtggtatgt aaataaatta gataatttat aagtcaataa aataagtcca
    64561 agttttatat taactaagtg gtatgtaaat aaatttgtaa tattatataa tcatcctaaa
    64621 acaaaaggtt ttatattaac taagtggtat gtaaattcga atgcta
//
LOCUS       DAEPID010000013        61420 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.013, whole genome shotgun sequence.
ACCESSION   DAEPID010000013 DAEPID010000000
VERSION     DAEPID010000013.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 61420)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 61420)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..61420
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.013"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            <1..302
                     /locus_tag="KR257_000948"
     CDS             <1..302
                     /locus_tag="KR257_000948"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729376.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=3
                     /transl_table=11
                     /product="AraC family transcriptional regulator"
                     /protein_id="HBH0029671.1"
                     /translation="NIKAFCDDTNINIKTLERICLKYTGYTPKILKRIYRFKMASNQL
                     IYNYKDDELFDFIYENEYYDQAHFIKEFKKFSGTSPIKFIGENKTIKENIKYSYL"
     gene            380..691
                     /locus_tag="KR257_000949"
     CDS             380..691
                     /locus_tag="KR257_000949"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416389.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="antibiotic biosynthesis monooxygenase"
                     /protein_id="HBH0029672.1"
                     /translation="MKIITEIVEFNVEENLSKEEFIEIVNDLELKFHSIQSGFIDTEL
                     LYDEKSQKWIMIQHWESIEDLKSASSKMFKDSSTEKFRKALKNQTVKMNIIPQIKSWK
                     L"
     gene            complement(818..2821)
                     /locus_tag="KR257_000950"
     CDS             complement(818..2821)
                     /locus_tag="KR257_000950"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416397.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha amylase C-terminal domain-containing
                     protein"
                     /protein_id="HBH0029673.1"
                     /translation="MKSQKRFKILDIDVYLQPFESDIKKRMKHYENMKSKTLKNYKDF
                     SSFANAHLYYGFHQTNDGFFYREWAPNADSLSLIGDFNNWNRKSHPLRKIGSGNWEIF
                     IPGQNSLPHKSEVKVQVTANGKTFDRIPLYIKRVIQKDFGGFNGQIWQPKTPFIWTDN
                     DFDLKNITYPLIYECHIGMSTESESIGTYNEFTEKILPKIKKAGYNTIQLMAIMEHPY
                     YASFGYQVSNFYAISSRFGTPEDLKNLINTAHSMGIAVLLDLVHSHAVKNTLEGINEF
                     DGSEHQFFHSGSKGNHPAWGTKLFNYGKPEVIHFLLSNIKFWLNEYHFDGFRFDGVTS
                     MLYHNHGLGVSFDSYEKYFSMNTDIEAITYLQFANELIKEIKPNSISIAEDMSGMPGM
                     CIPIKDGGIGFDYRLAMGVPDFWIKTISNLSDEDWDLGKMWYELTTRRPGEKNIGYCE
                     SHDQALVGDKTIIFWLADKEMYWNMEINSNNHVINRAISLIKLIKLITFSLAGEGYLN
                     FMGNEFGHPEWIDFPREGNNWSYKYARRQWSLSEDNNLKYKQLLNFDKSMLELTKYSD
                     IFIQNSHELIHMDNDKKILVYSKGKYLFIFNFHPNLIQSVDISKFQNTNYKTILNTDM
                     VEFGGNTKKENLRDYDVYFSSTPPSSKMPIASRTAIVLLDSSI"
     gene            complement(2974..3612)
                     /gene="recX"
                     /locus_tag="KR257_000951"
     CDS             complement(2974..3612)
                     /gene="recX"
                     /locus_tag="KR257_000951"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003431050.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombination regulator RecX"
                     /protein_id="HBH0029674.1"
                     /translation="MGIITKIEQQKRNDDRVNIYVDDKFFIAIFKELVYTFNLKKGNE
                     INEEELKPILDDEMYIKAKNKALNILSHADQSEKKLKEKLSSEFDENIIERVIDFLKS
                     YNLVNDSVLAQKIVNTNVNLNKCGKNRIKQNLYNKGINRSTINEAVSELDKDTEFENA
                     MYLAKKRYERVKKEDKKKIYQKISQHLSYKGFDYDIIKRVLNKLLNFDEYDI"
     gene            3888..4577
                     /locus_tag="KR257_000952"
     CDS             3888..4577
                     /locus_tag="KR257_000952"
                     /EC_number="2.7.7.18"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416411.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nicotinate-nucleotide adenylyltransferase"
                     /protein_id="HBH0029675.1"
                     /translation="MRSENLVKMAELKNTEKLEKFNRHKGKIKIGILGGTFDPIHYAH
                     LATAEFIRDKYDIDKIIFIPSGNPPHKLCITTDKYDRYNMTLLATESNEDFLVSKVEI
                     ERKKRTYTIDTLKYLKKKYKNADIYFITGADAICSVEEWKDVKKNFELATFIAATRPG
                     ISLLRSQETIEKLTKKYNADIITVYVPSLDISSTYIREQLNEGKSIRYLVPENVENYL
                     YENKLYQYGDD"
     gene            4578..5150
                     /gene="yqeK"
                     /locus_tag="KR257_000953"
     CDS             4578..5150
                     /gene="yqeK"
                     /locus_tag="KR257_000953"
                     /EC_number="3.6.1.41"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416414.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bis(5'-nucleosyl)-tetraphosphatase (symmetrical)
                     YqeK"
                     /protein_id="HBH0029676.1"
                     /translation="MNLENINQRLNQMLPVGRLSHSKNVAKCAEKLCEIYGCDKEKAY
                     LAGMIHDCAKYLSDKEIEDYVNKYEIYLDPIEDGNRSLSHSVIGAYICEYEFEVEDED
                     IINAIKYHTTGREDMSLLEKIIYIADLIEEGRKFPVVDTLRELAYGGKLDEALLTSFN
                     NTLMFVINKKEEIHPRTVMARNYLIKEKLL"
     gene            5267..5617
                     /gene="rsfS"
                     /locus_tag="KR257_000954"
     CDS             5267..5617
                     /gene="rsfS"
                     /locus_tag="KR257_000954"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416416.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribosome silencing factor"
                     /protein_id="HBH0029677.1"
                     /translation="MTVEQMTKIAYDAIEDKLGQDTVIINIGKVSSLCDYFIITTASS
                     QRQVKAIADNVEDELAKLGLEPRGKEGQGTQTWVLLDYGDIMVHVFNEENRGFYNLEK
                     LWKDAPYIDIDTLA"
     gene            5971..8391
                     /locus_tag="KR257_000955"
     CDS             5971..8391
                     /locus_tag="KR257_000955"
                     /EC_number="6.1.1.4"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416419.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="leucine--tRNA ligase"
                     /protein_id="HBH0029678.1"
                     /translation="MSVYNFKEVESKWQKIWKDNNQYKMDTAQTEKPNYYTLEMFPYP
                     SGKIHMGHVRNYSIGDVVARFKKMEGYNVLHPMGWDSFGLPAENAAIKHGIHPHKWTM
                     ENIEEMKEQLNLLGISYDWDKEVATSTPEYYRFTQEIFLKFLEHGLAYKKKSYVNWCP
                     SCETVLANEQVVQGACERCKATVLKKDLEQWYFKTTEFAEELLNDLDTLDGWPEKVKT
                     MQKNWIGKSTGADLVFDIDGTDKSMTVFTTRPDTTYGVTYMVLAPEHELVKELVAGTE
                     YEADVEAFVQKMHTMTEIERTAADVEKEGMFIGRYVINPLNGKKVPLWIANYVLVEYG
                     TGAIMAVPAHDERDRDFAEKYNLDIIDVITEDNKMINSEEFNGLDASEGFEGIIDKLE
                     KEGRGKRTINYRLRDWLVSRQRYWGCPIPVVYCDECGIVPVKKEDLPVLLPTDVEFTG
                     KGESPLTTSKQFMSTTCPHCGKPARREVDTMDTFVDSSWYFLRYVDSNNENEPFSKEL
                     VNRWHPVDQYIGGVEHAIMHLLYARWFVKAFKSMGMVDFNEPFKNLLTQGMVLMDGSK
                     MSKSKGNTVSPMDIIDEYGADTARLFVLFAAPPERDLDWSEQGVDGCFRFLNRVYRLV
                     DELADVVKKDVEFGELNSQDKDMRYTIHSTLKKVTADLSEKFGFNTAISALMELINDM
                     YKYKELDNINEAVIKEGVQTIVTIIAPFAPHLGEELWTMIGKEGSVFDIDWPKYDEKA
                     LVKDEIEVVVQVNGKVRGKLTVNSNISKDEMEKVALEDEKIKGLVEGKTIVKVVAVPK
                     KLVNIVVK"
     gene            9227..9895
                     /locus_tag="KR257_000956"
     CDS             9227..9895
                     /locus_tag="KR257_000956"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861580.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="VanZ family protein"
                     /protein_id="HBH0029679.1"
                     /translation="METVTNNQSGVEIQLSLFEAIKDLLLINPIFLLGIILIGIFLVV
                     IFKKNSDIPKVKTSILSLAMYYYLCLTLSHIVGIPTFGEYIRLSQLGETFFNPNINLI
                     PFSDGFSLSFILNILLFVPLGFLCPLISKTFERLRNTFLIGFGLSLFIETIQLFTLHR
                     ATDIDDLLTNVIGTIIGYFCFKLIAKLRIVKLHSDDDSMEQDYTVCIPIAIIIVALIL
                     GFFS"
     gene            complement(10213..10485)
                     /locus_tag="KR257_000957"
     CDS             complement(10213..10485)
                     /locus_tag="KR257_000957"
                     /inference="COORDINATES: protein motif:HMM:NF012798.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tyrosine-type recombinase/integrase"
                     /protein_id="HBH0029680.1"
                     /translation="MSKHQFKSVSTFFTKKNVSQFYKKNNLKKIRIHDLRYTSATLLL
                     LGGTNMKVVSERLGHTDIKITMNRYSHVLKEMDKEASDNLSELLFK"
     gene            complement(10716..11137)
                     /locus_tag="KR257_000958"
                     /pseudo
     CDS             complement(10716..11137)
                     /locus_tag="KR257_000958"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003431042.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
     gene            complement(11156..11254)
                     /locus_tag="KR257_000959"
                     /pseudo
     CDS             complement(11156..11254)
                     /locus_tag="KR257_000959"
                     /inference="COORDINATES: protein motif:HMM:NF026008.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus and C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="Arm DNA-binding domain-containing protein"
     gene            11537..12907
                     /locus_tag="KR257_000960"
     CDS             11537..12907
                     /locus_tag="KR257_000960"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861578.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell wall-binding protein Cwp29"
                     /protein_id="HBH0029681.1"
                     /translation="MKLKKLLSLGLAVSMFAAGPISANALDTIYTIQGKDKYETAALI
                     ADEQNYTTAILINADSTMADGLSASGLAGATNAPIFLTKKNNIPNATLKRVEKAKKVY
                     IIGGESSIDKATETLLKDKGIEAKRLQGSDRIKTSYNVAKEINSINKVNKVILTNAFK
                     GEPDAMSAAPVAVRDKAAIVLTDGKSVPFNTTGVESYVIGGTSSMSDKLVNDTNSTRL
                     GGVDRYDTNKKIVNKFYNGAKEFYIASGTDLVYALVASPMAKNNPIVLVDIGSNKDIL
                     KNAAKVTGIGNLSDKIMLECENTINNISLPSSNKNIICGLKIDFDSKHIIWQDKGSYL
                     ECYDDNLEYYTEKYKDPTVPINIENTSTQNLDVTKLKVYGEANSTLYMGQYAKIKMDF
                     NSFGVLKPGEKCTIYLDIISLDPSRSMTLTFSYVGDKENYKYEQGLASRILFYNPDGE
                     DFFEYK"
     gene            13266..13424
                     /locus_tag="KR257_000961"
     CDS             13266..13424
                     /locus_tag="KR257_000961"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003431040.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0029682.1"
                     /translation="MDNFLQGILASLSASLIVYIASKLFRKRKKPLKAATKSGWEFDL
                     KIRFHKTK"
     repeat_region   13710..14067
                     /inference="COORDINATES: alignment:crt:1.2"
                     /inference="COORDINATES: alignment:pilercr:v1.02"
                     /rpt_family="CRISPR"
                     /rpt_type=direct
                     /rpt_unit_range=13710..13738
                     /rpt_unit_seq="gttttatattaactatatggaatgtaaat"
     regulatory      complement(14209..14306)
                     /regulatory_class="riboswitch"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF01051"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="cyclic di-GMP riboswitch class I; Derived by
                     automated computational analysis using gene prediction
                     method: cmsearch."
                     /bound_moiety="cyclic di-GMP"
                     /db_xref="RFAM:RF01051"
     gene            14532..14915
                     /locus_tag="KR257_000962"
                     /pseudo
     CDS             14532..14915
                     /locus_tag="KR257_000962"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003431032.1"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="BlaI/MecI/CopY family transcriptional regulator"
     gene            complement(15104..16099)
                     /locus_tag="KR257_000963"
     CDS             complement(15104..16099)
                     /locus_tag="KR257_000963"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003431031.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="asparaginase"
                     /protein_id="HBH0029683.1"
                     /translation="MSIKKKVAIVFTGGTISMTVDDKVGAAIPTLSGEQILSMVTNID
                     KVADVEVFNFDEIPGPHITPYRMMELKNYVNDLLARKDITGVVITHGTDSLEETAYFL
                     DLTIDNIKPVIVTGAMRSSSELGYDGSSNLSASVCTAVSKDAMGKGVLVVLNNEVLLA
                     SEATKTNTLSLNTFKSLTSGPLGIIDCNELVLTRDIVNRTIIDTDKVESKVALFKAYV
                     GENADFIRFAVDSGYKGIVIEAMGRGNIPPQMLSGVEYAREKGLPVVIVSRCHSGRVF
                     DSYGYFGSGRDLKNLGCIFGGDLPGQKARIKLILALGKTDNLDEIKDFFEKGIYC"
     gene            complement(16220..17848)
                     /gene="aspD"
                     /locus_tag="KR257_000964"
     CDS             complement(16220..17848)
                     /gene="aspD"
                     /locus_tag="KR257_000964"
                     /EC_number="4.1.1.12"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416436.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aspartate 4-decarboxylase"
                     /protein_id="HBH0029684.1"
                     /translation="MKNHTYKEIKNIYGKISPFEFKDKLIDIAKYTAKENNRELLDAG
                     RGNPNWTCSTAREAFFTFGHFAITETRSNWDLGHLAGMPQKKGIKERFFKFINENIDM
                     PGAYLARDIINFGINELGFDGDEFVHELADGIIGDNYPLPDRMLPHMEKIVHDYLVQE
                     MKYDISGKYGDVEIFAVEGATAAMCYIFDSLMANELLKKGDTIALMTPIFTPYLEIPN
                     LPRYDFKVVNINANEVDEKGAHTWQYTKKELEKLRDKSIKALFVVNPNNPASIAMDET
                     SCNNLIDVIENYNKDLMIISDDVYGTFVEDFSSLMSKLPYNTVGVYSYSKYFGVTGWR
                     LGTFALHKKNVFDKKINDLTGELKKSVDKRYSDMSLNPSSLSFMERVVADSRLVALNH
                     TAGLSTPQQVQMAFFSAFALIDKVDAYKKLNMSICHRRQKLLFEALELPINENKNNAA
                     YYTQFDIEEWAKLNYGEDLFKFISKTASPVDVLYKLANDYSVVLLSGNGFYGPEWSIR
                     ISLANLYDEAYTKIGKAIREILNGYIVEWQKIKK"
     gene            18507..19724
                     /locus_tag="KR257_000965"
     CDS             18507..19724
                     /locus_tag="KR257_000965"
                     /EC_number="4.3.1.19"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009905953.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="threonine ammonia-lyase"
                     /protein_id="HBH0029685.1"
                     /translation="MMNVTLTDVKEARETIKNIVKRTDLLESVKLSEKTGANVFYKCE
                     NLQKTGSFKLRGACNKIASLTDEEKANGVIASSAGNHAQGVALGAKMTGIKSTIVMPA
                     TAPLAKVSATKGYGAEVVLNGAVYDDAYAKAVEIQKETGATFLHPFNDKYVIAGQGTI
                     SLEIFEQLDNKVDTILCPVGGGGIISGVAVAAKALNPNVKIVGVQTANIPSMKESIKN
                     GKVTTAFNDTTIADGIAVKTPGDLTFEIINELVDEIVVVEETEIAESILFMMESQKIV
                     SEGAGAVCTAAILSGKYVPAKDENVVCIISGGNIDINTLYRIIGVALAKEGRRYSFST
                     IMEDKPGNFAELTRIISENGGNILSANQGKLSAGEALGKQSAEFILETIDYDHIARIK
                     KAIEEKGFKIIEL"
     gene            19819..20199
                     /locus_tag="KR257_000966"
     CDS             19819..20199
                     /locus_tag="KR257_000966"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416451.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RidA family protein"
                     /protein_id="HBH0029686.1"
                     /translation="MKHEVIHTNDAPAALGPYSQAIKAGNLLFVSGQVPLVPETMEVV
                     EGDVQAQTAQSLKNLKAILAESGADFSNVVKTTVFIKDMNEFGAINEVYAEYFGENKP
                     ARACVEVARLPKDVKVEIEVIAVL"
     gene            20483..20965
                     /locus_tag="KR257_000967"
     CDS             20483..20965
                     /locus_tag="KR257_000967"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416454.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS glucose transporter subunit IIA"
                     /protein_id="HBH0029687.1"
                     /translation="MLNFFKKNKSYKLHAVVSGNSINIEKVNDSVFSKKLMGDGVAII
                     PNSNVVVAPCNGKVTVLTESKHAFGMVSDEGVEILVHIGIDTVSLQGEGFKNEVSQGD
                     TVKKGSPIISFEREKINSQGIDCTTIIIVLNHSEFSEINCMVENEVVAGQDTVIEIMK
                     "
     gene            20986..21801
                     /locus_tag="KR257_000968"
     CDS             20986..21801
                     /locus_tag="KR257_000968"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009905948.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PRD domain-containing protein"
                     /protein_id="HBH0029688.1"
                     /translation="MRVVKIFNNNALSTVTNDRKEAILLGLGIGFNKRPGDKVNEDKI
                     EKIYYVQDHMQTKFLELLKNVSPEVMDASQQIISLIPGNEGKFNNKGILSLVEHISFA
                     IDRMKNNVFLPNLMLLDIKMMYSKEFELGVKALEIIYRVCHIHLPEDEAGYIALHFVN
                     LQSNDNLAYDTLKFVKGSIDLIKECYGLELDESSLSTLRFRTHLKFLAQRIFKNEICQ
                     DDKMIEMYDYLINNHPKNKEYLEKLNVYIEKEFRYKLDKPEKIYLLLHLTKIL"
     gene            21854..23404
                     /locus_tag="KR257_000969"
     CDS             21854..23404
                     /locus_tag="KR257_000969"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003431026.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS transporter subunit EIIC"
                     /protein_id="HBH0029689.1"
                     /translation="MKEKLLGGLETFAKAMVQPLMYLSSAGILMVVGVLLTNDMLLGV
                     LPFFKWEPIQIFGSLIYNCIMAIINNLAVIFAIGIPAALAKKEKHKAALIGFMSYIIY
                     LTASNTMLTSLGQLAKESKMLGLIGTGQATILGIQVVDTSVFGGIILGYIAGYVFNRT
                     SNKTFKGALQIYSGANFSFICMFFVSILIGVVSNFIWPLAQQGIASLANVIKDTGTFG
                     LFLYGFLERILVPTGLHHLIYTPFQFSDLGGVLKVGADTVSGAYAIVMTEMNLPVERF
                     SDSIYYMATGFTKMFGYIGIGAAFIYTAYKQNKKKVKATIIPLIITAVLASVTEPLDF
                     MFVFCAPLLFFVHAVIAGLFIALLKIFDVTALCGGNLLVSVIMNTTVGVEKTHWPVMM
                     ILGLAQIIVYFVVFSFLIKKFNYKTPGREDESTATGEEQSKQLNLDAGIENIIDGLGG
                     KENINTVENCITRLRVNVKDESKINEDIINLTPNSGIVRKGKDIQIIFGLHVHEVRRA
                     VEDFLEAY"
     gene            23501..24853
                     /locus_tag="KR257_000970"
     CDS             23501..24853
                     /locus_tag="KR257_000970"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003431025.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="6-phospho-alpha-glucosidase"
                     /protein_id="HBH0029690.1"
                     /translation="MIITIVGGGSTFTPGIVKSIALREKELELEEIRLFDIDKKRQDK
                     VAVVVNWILKEDVKTDVKLTVTNCEKEAYTDATFIFAQMRVGKYEMREQDEKIPLKYG
                     CVGQETCGCGGMAYGLRTIQPMIKVIDDVEKYAKKDYWILNYSNPAAIVSEACRKLRP
                     NARIINICDMPIAIIDMIAGSLNINDVHNIRYDYFGLNHFGWFTSIDYKHRDLMEEIK
                     EYIKENKILLPKSYIENLNKSRSTGNRHAVSSWIHVWESVYTMLESFPKYLPNTYLTY
                     YLLSKETVEHSNINRTRANEVMESREKDLFEGVRHYLETGEISEKAFYAGSHGDWISD
                     LAVSIKNDTRSRFLVITENRGAIPNMPYDAMVEIPAYIGKDGPEVIARGPIPLFQQGL
                     MMQQLNSEKLIVEAYIENSYEKALQAFTLNKTIPSMNVAKEILDEMIEVNKEYWPELR
                     "
     gene            24984..25742
                     /locus_tag="KR257_000971"
     CDS             24984..25742
                     /locus_tag="KR257_000971"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897697.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HBH0029691.1"
                     /translation="MNIINKIFWQEDRIGMITNNLEADTHSHCMLQLFLGIEDSIEIT
                     VNEKLVKCNCIIVDKNISHSFSARKKVYYSAIIEPTSIYAEQLTSKMNDFGYWICDND
                     GLEKLRQQGTFLISNSSKEQYLRFMEMLNNYLNIPITLKHYDDRITELFNLLHTCNCD
                     NHTISSFADKVSLSASRLSHLFKEQIGIPLKSYILFHQMECAFRELLSGKNVTEASMT
                     AGFDTPSHFAGTVKRMMGMPVSLSLKDSEFLKVY"
     gene            25789..26508
                     /locus_tag="KR257_000972"
     CDS             25789..26508
                     /locus_tag="KR257_000972"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728769.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transglutaminase domain-containing protein"
                     /protein_id="HBH0029692.1"
                     /translation="MNKEYLEETKMLNYNEPQLKLLVSSKNWLELDDFHKIKSIYEFV
                     QNDILFGYNASDMLSATQVLNDGMGQCNTKATLLMALLRAVNIPCRLHAFDVTKDFQR
                     GATSKLISLLAPKYILHTWVEVFYQDRWIALEGVITDKKYLEAIQKKFFNHGGTFKKY
                     AIATNDLKNTSIDWDGKDTFIQKEAIVYDYGIFPSPDVFFSTHSQHMSKLKNFIYVHL
                     IRKIMTKNVCKARNNYIDKNE"
     gene            complement(26632..28032)
                     /locus_tag="KR257_000973"
     CDS             complement(26632..28032)
                     /locus_tag="KR257_000973"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416474.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="multidrug efflux MFS transporter"
                     /protein_id="HBH0029693.1"
                     /translation="METQSNNKKGNLIIAIVMTGAFISSLSQTLLSTALPNIMSDFKI
                     TADVGQWLTTIYLLIAGIIVPTTAYLINRFSTRKLFITSMSIFSIGCIIALFSNNFST
                     MLIARVLQAMGSGSLMPLLQVIILYLCPEEKRGAAMSLVGITVGFAPAIGPTLSGWLV
                     DSFGWHSLFLFLSPIAILDVILSFILLRNVGETQKLKLDIPSIVLSSLGFGGLLIGFT
                     NQGNYGWTNIATYLPILIGIMSLILFTLRQLKSKEPFLELRVFKNKPFLISTILIMIV
                     YASMMSATLMIPLYVQSVRGFSALSSGSLMLPGAILMVVLNPIAGRHLDKYGPHALSI
                     LGTGCLFLGTLSFAFLGRDTSLIHVSLMYCIRMIGISMVLMPLTTWGIKTLDRELISH
                     ATAINNTLRQISGAIGSAILITIMTSATKKAHMSSNMLSNIHGIDVAFSIAATLAFTG
                     LIVSICFIKRHQIIRS"
     gene            complement(28036..28944)
                     /locus_tag="KR257_000974"
     CDS             complement(28036..28944)
                     /locus_tag="KR257_000974"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454802.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="HBH0029694.1"
                     /translation="MKGDNKVTEKQRLIITIAQKIFDQKGFQNTSISDVVKECKMSKA
                     TFYKHFETKESFICEIINYYDEKFLEIIHSINENNDIPASEKLNRKIIAVWKNIFSRT
                     TINTYIRENFSEEQRKATSKLQTKSRANLLNEYKLSLFDNYGDKIEKIIFDLVFLLDA
                     LIHQFIYIIHVQKREINVYFIAKFTIQILDLVVENMDNLNPLIEKSMFLHKQEDEVYF
                     SLHNKSLFFKMIQDIEELIKTDTSLLENPKLLEAIKKLYVEGKNQQYDSLIMDAMIAY
                     LEKEDTLRPKVLLLNSIKNQLKKETL"
     gene            29205..29852
                     /locus_tag="KR257_000975"
     CDS             29205..29852
                     /locus_tag="KR257_000975"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416477.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="M15 family metallopeptidase"
                     /protein_id="HBH0029695.1"
                     /translation="MKKKICVAIIFALFIVFVEMFIDSSSEGSKIMTAELSKYRKGVN
                     VLSINNIIVANKKYSLPKDYSPQESSEARDAFYKMNKDAQKSGLNLKAFSTYRSYEYQ
                     DRLFKSYVKEHGEKEANRFSAKPGESEHQTGLAFDIGGDDQSCWANKKFNNTKEAKWL
                     YENAYKYGFILRYPEGKENITGYMYESWHYRYVGTEHSKNFAMNNLTLEEYLHIN"
     gene            30176..32815
                     /locus_tag="KR257_000976"
     CDS             30176..32815
                     /locus_tag="KR257_000976"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861573.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cation-translocating P-type ATPase"
                     /protein_id="HBH0029696.1"
                     /translation="MSYKSTYQEVIKNLDSSLSGLSKERAEELLEKNGANELKEADKV
                     PTYKLFLESFKDPLVIILLIAALVQIFLGETVESIIIFAVIIINSVLGVVQTKKAESS
                     LESLKNLSAPNAKVIRDNKKMTIPAKNLVVGDIVFLEAGDYIPADGRLIEAQSLKVVE
                     GMLTGESEPVLKHTEKISEDVSLGDQKNMVFSGAVVVYGRGSFVVTGTGMDTEMGKIA
                     GLLESAENKLTPLQQKIEDFSKKLGVGIVILALLIFIIQVARNYFMAGNGEMTQIILD
                     SFMFSVAVAVAAIPEALSSIVTIVLAVGTNSMAKKQAIIRKLPAVETLGSTSVICTDK
                     TGTLTQNKMTVVDYYMYGTNNDELDKEKVNYSYHAKLLTMVSTLCNDSHITSDGKEVG
                     DPTEVALINYSSKNDLDYDKLRSKYIRINEIPFDSDRKLMSTVNSIYGDYIMFTKGAP
                     DIVFSRCKYALKNGSKVDITDEIIEEYKHKNEEFSNRALRVLAFAIKDVPEEDFIPSI
                     DDEHDMTLVGIMAMIDPPREEVMDAVKEAKSAGIKTVMITGDHKTTAAAIAKEIGIME
                     EGDLALTGKELDALSEEQLYEKLENISVYARVSPENKIRIVKAWQHKNNITAMTGDGV
                     NDAPALKQADIGIGMGSGTDVAKDASAMVLVDDNFASIVNAVEVGRTVYSNIIKSITY
                     LFAGNLGAIVSIVFAVFAGWSNPFTALQLLFINLVNDSLPAIALGFEKSEKNIMNKPP
                     RHPDESILAGGTLKAVAIRGCIIGVVTIIAQYIGLQVSPELGVAMAFSTLILARIMQT
                     LPARSNNQTVIKLGFFSNKYVIGAVLVCLGLYSLTLIPVLRGIFSIPTTFGLYQLGIC
                     LGLALISSILMELNKLINRSEVK"
     gene            complement(32873..33976)
                     /locus_tag="KR257_000977"
     CDS             complement(32873..33976)
                     /locus_tag="KR257_000977"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416482.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="histidinol-phosphate aminotransferase family
                     protein"
                     /protein_id="HBH0029697.1"
                     /translation="MKLKINKAIEMQLKKSYAIESGHSEDVFEIDCGEGINTVSYSNK
                     AVEAFNALKFDMIRGYPHSIALKDNIVDYWKDFIALDTDRICLADGSIHVIYLLNRLF
                     IEKGDKVLGYSPQFSEYETDIKMHGATYDYVLLKKEDNFKFNEKEFIEKINPEYKVIY
                     IDNPNNPTGQIIHLSSIENIVKEAAKYDIAVMVDEAYGEYMPKENSAVKLLNNYDNVI
                     ALKTFSKGFGLAGLRAGYAVLPEQLVSPIKKISTPYEVSEISRSIAANLLDDVQFIEE
                     LKEKTKDIKNQLLIPWKNLNIAETSDTVSIMTVEHKNKDIDLQQEFAKLKIRVISGSD
                     FTGLDKNFIRFRMPEEKELPEVIKAFQIIDNIE"
     gene            34337..35158
                     /locus_tag="KR257_000978"
     CDS             34337..35158
                     /locus_tag="KR257_000978"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454798.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Cof-type HAD-IIB family hydrolase"
                     /protein_id="HBH0029698.1"
                     /translation="MGYKLIVTDMDGTLLGNNHKVTDENKTALQKVIKSGINVTLATG
                     RAFDSAKCNVDFLKEDMPIIACNGSLIREQNGNIIYSNKIDTRTCLNILDVLDKYDIY
                     YQCNSIDSMLSKKIEGREDRLSVFLGSETEVIVKDDLREEIFKKDILKFVIIEEKNPS
                     ILDEIRKELRKVQGIKITSSWPNNIEVMNEGVDKGNAVKILAEKMNIDREDIIAFGDN
                     YNDIEMIKFAGLGVAMGNAEELIKQEADYVTDTNQDSGVAKAIYKFLELKESLSS"
     misc_binding    35237..35448
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00230"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="T-box leader; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /bound_moiety="tRNA"
                     /db_xref="RFAM:RF00230"
     gene            35535..36851
                     /gene="argH"
                     /locus_tag="KR257_000979"
     CDS             35535..36851
                     /gene="argH"
                     /locus_tag="KR257_000979"
                     /EC_number="4.3.2.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012101354.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="argininosuccinate lyase"
                     /protein_id="HBH0029699.1"
                     /translation="MKLWGGRFRKAENQLMEEFNKSFGYDCVLYKKDIEGSVAHVHMQ
                     VKCGLLTEEEGKSITEGLKGILEDVENGKLVLDGEYEDIHSFTEINLIQRIGDVGKKL
                     HTARSRNDQVAVDMRLYAKEKANDLVGLISEFKATIKDVADKNPVMMPGYTHLQRAQV
                     VTFKHHLMAYYSMFDRDEKRIKNAIEILDESPLGCGALAGTTHDIDRSITCEQLGFKK
                     VVDNFMDGVSDRDYLLELMSDFSIIMMHLSRLSEELILWSSQEFGFVEIDDLYTTGSS
                     IMPQKKNPDGAELIRGKTGRVYGNLFGLFTVMKGIPLAYNKDMQEDKEGFFDSVHTLE
                     MCIQIMDRMIATLKVNEDKMKQAVKNGFLNATEVADYLVKNNVAFRDAHGIVGSIVIY
                     CEDNKKAIEDLTLEELHKFSDAFKEDIYDFIDYESILNKGIKKNLK"
     gene            37100..37438
                     /locus_tag="KR257_000980"
     CDS             37100..37438
                     /locus_tag="KR257_000980"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890712.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF2325 domain-containing protein"
                     /protein_id="HBH0029700.1"
                     /translation="MNLLVIGGHERMEKDYMVMAKKKGYKTKVYTTMSSKLNNSIGRP
                     DAVVILTSTVSHKMSRTVESQAKKQDILIVRHKNSSKVAFNECLDMVDECLGNCSKCK
                     LKDKQKQKNI"
     gene            complement(37565..38854)
                     /locus_tag="KR257_000981"
     CDS             complement(37565..38854)
                     /locus_tag="KR257_000981"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454794.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="D-alanyl-D-alanine carboxypeptidase"
                     /protein_id="HBH0029701.1"
                     /translation="MKRNLSLLLICLLIFTSFLGSSNISFADNEPAIVAKHAVLMDYE
                     SGKILYNKDGNSKLYPASTTKVWTACLVLKEVKDLNQVIEIKDLPQIDGSSMYLKNGE
                     SFTVKQLLDALLVHSANDAAFVLARYVGGGNVQKFIDLMNSEAKKIGATNTHFNNPHG
                     LPDPNHYTTAHDMALIAREAMNNDTFRQIVKTKSLKFEATKAYPYERYFVNTNKFLTS
                     HDKITYKGQPINIKYDIVDGIKTGYTDAAGKCLLSSAVKDGRRVIVAVFNSTNADLYL
                     DSRILIDYGFDNFKCATIVDKEKYTDTKKVLFTKQHELIYEPKNSYRIFLEKDESQGN
                     YDTKTELNKIDLPIKKGAKVGTLNVYNNGKLENSIDLIAKNNLDSSLPFFTGNNILMT
                     FVKIIAGILVLLVLFIIASNIKKKKRKKARSKKNMKK"
     gene            38934..39638
                     /locus_tag="KR257_000982"
     CDS             38934..39638
                     /locus_tag="KR257_000982"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728771.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-hairpin-helix domain-containing protein"
                     /protein_id="HBH0029702.1"
                     /translation="MKKKVKFISFFVLFILIISSIIVYKSLIFKDDIYVVSKKNLPNE
                     KTHVVENEIKGEDNNHNKVTKDIDKNFQNNKITIYISGAVNRPGIVTIESDKRLYDAV
                     ELLGGTTKEADLNGVNLSVRLEDEQHYIIPKIGEATSVTSNDDSNKPNQRNESRGEPK
                     NKSNKNISNESKVNINVATIEELDSLPGVGEATANKILQHREENGQFSSIEEIKNVNG
                     IGDKKYENIKDLICVD"
     gene            39730..40776
                     /gene="selD"
                     /locus_tag="KR257_000983"
     CDS             39730..40776
                     /gene="selD"
                     /locus_tag="KR257_000983"
                     /EC_number="2.7.9.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015617929.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_except=(pos:39778..39780,aa:Sec)
                     /transl_table=11
                     /product="selenide, water dikinase SelD"
                     /protein_id="HBH0029703.1"
                     /translation="MKKEQKKLTEMTTAGGUAAKIGPEVLASVLSQLPKNDNIENLLV
                     GLDTADDAAVYKLNDDMALIQTLDFFTPMVDDPYVFGQIAASNSLSDVYAMGGKPLVA
                     MNIVCFPSCHDMDVLAEILKGGFDKVKESGALLVGGHTVDDKEPKYGLSVSGIVSPNK
                     VLSNATAKPGDKLIITKPIGVGVLNTAMKEGMVEQHIADKVIEIMIHLNKYAAMSFEK
                     FDVNSVTDITGFGLLGHTLEMAKASEVSIEIESKHVPIIEGAIEMAQMGIIPAGMYKN
                     MHYVSKDVEVVGNIEVAVQDILYDPQTSGGLLISVKEELAEELVKDMKLNGAIEAKII
                     GSVVPKGEKYITVL"
     gene            40794..42206
                     /locus_tag="KR257_000984"
     CDS             40794..42206
                     /locus_tag="KR257_000984"
                     /EC_number="2.9.1.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454789.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="L-seryl-tRNA(Sec) selenium transferase"
                     /protein_id="HBH0029704.1"
                     /translation="MIVLSKRELFAMLPSVDEVLSDNRIVEIINEYPRSLVLESVREV
                     IDLKRQFILRLKEDASNSVTIEFGEIIESAIERVKLNYSLSLKKVINATGTVIHTNLG
                     RSLLSEDIKDELWCAASRYSNLEYDLDNGERGSRYSHLTSTIKRLTGAEDVLVVNNNA
                     AAVLLVLSTMAKGGEAIVSRGELVEVGGSFRIPSIMALSGAELVEVGSTNKTHLKDYK
                     EAITEDTNVLMKVHTSNYRIMGFTESVSIEELVNLGKKYKLPVIEDLGSGVFIDLSKY
                     GLSYEPTVLDSIRQGADVVTFSGDKMLGGPQAGIIVGKKEYIEKMKKNQLTRALRVDK
                     LTICALEATLRMYLDETKAIENIPTLKMLTYKIEELEVKANKLFEKITALNLNANINI
                     EDGFSQVGGGSMPLETISTKVISITPEHMNVSSLEKKLRLSEAHIIARVYDNKYVLDV
                     RTIFDDEFDVIVEELRKAFN"
     gene            42320..44203
                     /gene="selB"
                     /locus_tag="KR257_000985"
     CDS             42320..44203
                     /gene="selB"
                     /locus_tag="KR257_000985"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416497.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="selenocysteine-specific translation elongation
                     factor"
                     /protein_id="HBH0029705.1"
                     /translation="MKNVVIGTAGHIDHGKTTLIKALTGRETDTLDEEKKRGISINLG
                     FTYFDLPNNRRAGIVDVPGHEKFIKNMLAGASGIDIVLLVVAADEGVMPQTVEHLDIL
                     SFLNIKNGIVVLTKSDTVDDEFRELVKEDICEKIKGTFLEDAEIIEVDSISKRGIDTL
                     IEKIDKMSDDIEDKNENSPARLNIDRVFSIKGFGTVITGTLIEGKISIEDDLVIYPQV
                     LKTKIRSIQVHGENKDTAYAGQRTAINISNVKVDDIKRGDVLAAPNSLEESMMLDVKL
                     SLVNHLDKGLKHWDRLRLYHGTREILCRAVPLDKELIESGESGYVQLRLEESIVSKKG
                     DTFVVRRYSPMETIGGGVIIDPSPKKHKKFDEKVIEALKIKEKGELKDIIEEYLKRNL
                     KNYPNIKEIMSYSGAHEEDVKRALETLISEDKVFIIGNMYMHINQYNKLKENTIKLLS
                     EYHKKYRLRKGILKEEVRSKIESNFKTREMDILLEKLSTENAIKIENNIVSLLDFEVI
                     LNDKQKEIAKKIEKRLKSCGVSSILTIDEVSEGNHNYAEVLESMIGNKVEKLDDLYIM
                     DKDIYENAKNILINYIKENKEITLGEYRDLIDSSRKNCMIILENFDRNKITKRVENKR
                     ILF"
     gene            44308..47046
                     /locus_tag="KR257_000986"
     CDS             44308..47046
                     /locus_tag="KR257_000986"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454784.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sporulation-associated two-component system
                     sensor histidine kinase"
                     /protein_id="HBH0029706.1"
                     /translation="MKNIIPDVKPDIKEREDMSLLFIIMGSVLLLFIIKDIEKYETLL
                     HAIYTIFLVATGVIIFNTTKFKVDSFSTFLGLIFIATGVLECIYLFNSLGIKTKSIME
                     INITISAITDLFPILGVYLSFKFVKDNKQIYSSVILFIATATLTITSLFIISGICDYL
                     GNGKSQYALGVIISIFIIIISIISGIELNSSSNKGKWEYDEKKIFNRIIVIIILSRVP
                     NLLHIVIDNRNVERILSQIIINVALYYLYNYIVSKNIKKTALELHDTNEELTKKTESL
                     KEKNKKLIYETEKIEELKGILMKRESRLQSTLDVAVNSIVVFSKDGEITYANKSFRNT
                     FGDYKEQDKLTDKIKNFNDLIESIHYVFVHEKNAEKLISTSDNKVYQAIFAPLIIASQ
                     TEGVLCVLEDKTKKKEYERKLIEANKRSKDFLESIGDGIVVLEGNNKIYVNNACREIF
                     KNNLESIDFSLVCKSEESIEKRYVIDGEVKYVEMSFSQYTNAGTNKTIIVIRDTTSRK
                     ISQIKLEESQSSYSRFIDILPDGICLLKEDLSINYANKSFLDMLAFTNIDDIKDSNIK
                     LLMNANTEEKMKFTDNMAKVLNENRSILLLEYELINSYDDIVEVELSALPFAIYNTRY
                     IMLIIKDLVHKKYSEQAEKELLERFKTDKIKTEFFANMSHELKTPLNVISSSNQLVDS
                     FYRNEKIKDYNNNIKSHVDLVRQSSYRLQRLINNIIDLTKMESGFYTLKLAKYNIVSV
                     IEDLFMNIEEYALRKDIKILFDTDLEEINVYIDKVEIERIMLNLLSNCIKFTDNGGWI
                     YVSIHYKIDKVIISVKDTGVGIPQDKLELIFEEFSQVDKTLSRNTEGSGIGLAIVKNL
                     VSLHGGDIEVVSEVNKGTEFLISLPMKGFSSEHYTEDKRIYNIQEKIKIEFSDIYY"
     gene            complement(47165..48109)
                     /gene="manA"
                     /locus_tag="KR257_000987"
     CDS             complement(47165..48109)
                     /gene="manA"
                     /locus_tag="KR257_000987"
                     /EC_number="5.3.1.8"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430987.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="mannose-6-phosphate isomerase, class I"
                     /protein_id="HBH0029707.1"
                     /translation="MEPLFLKPIFMDRIWGGTALKDKFNYEIDSPTTGECWAISSHKN
                     GDCLIENGKYKGKKLSELWNKNRELFGNTPGDKFPLLTKILDANDNLSVQVHPNDEYA
                     KKNENGELGKTECWYVIDCSDDAEIIIGHNAKSHKEFVNMVNNNEWDKLLRKVNIKKG
                     DFFYVPSGTIHAICKGTLILETQQNSDTTYRVYDYDRTDNSGNKRELHVQKSIDVTNV
                     PHINFDTDYKIVSTSDFKCTTFVSNEFFSVYKLDVFGKCNFTHNTPFSLYSVLDGNGK
                     LIHNSVEYNLKKGMHFILPNDFGDFSFEGNLEIICSHI"
     gene            48282..49643
                     /locus_tag="KR257_000988"
     CDS             48282..49643
                     /locus_tag="KR257_000988"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728775.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="M20 family metallopeptidase"
                     /protein_id="HBH0029708.1"
                     /translation="MELFKAESKKYKKEFLKLLEQWVSIPSFYDRKTVSKDMPFGKGV
                     YDALNWFENLGRENNFKVKNIDNHAVQIEYGNGKEYVDIFGHCDVVNPGEGWDSEPFK
                     LNIIGDKLVARGVSDNKGPMIVNFLALKMIKDLDINLKRKVRLIAGGNEESGFKCIKH
                     YYSKEPYGVCGFTPDAKFPVLNGEKGGAIIKLISNIDDKSLYISGGIEFNTIPDKVYI
                     KNVEKLGKDNICFDINNISINYDNGNYIVYGKGGHSSKPEKSINPILATIKLLSENID
                     EKWTKDLYKLINQDNINGNLFGLNIEGKCGILSMVPTIINIVDGKLEVVLSVRYPEIL
                     TIEDIIKKFNLYMEQNNINKFELIGENLKQANYIDRNSKLVRSLHDIYIKYSGDLKND
                     VRVTSAGSYASEMNNSVIFGCEFPDGSFGNVHSANEFASLDRFITAIGIYAEAIITLC
                     NKI"
     gene            49731..51620
                     /locus_tag="KR257_000989"
     CDS             49731..51620
                     /locus_tag="KR257_000989"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890703.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcription antiterminator"
                     /protein_id="HBH0029709.1"
                     /translation="MITKKHAIIVKSLSNKDGYMTSNELAIKLDVSTKTIKRYIADLN
                     SVLSKYDLVIASSRGIGYKLSGSKNNIARAVKEANKYIDGFLDDSEESRMSNIICMLI
                     NRNYMSIEAMAEELNLSIAAINKLSSKLKRKLEKYDLVIKSKPYYGSYIHGEEINIRQ
                     LITDYAIKLDEKSKVKVFLDDISENDIHCIESILEKHLREKDTIISDKDFNLLLSKII
                     VSVFRSKRGHSNNINLMDTSYRFHNYYFIENLMKEISDKIGFKLIEDEVIYISNYSGV
                     IAYKGTQGRKNTSEIEERISTVISSALQDIFLISGSDYTKDDEFMVAISDHIKRFLNR
                     ARANVKSNNPLLHQIKEKFPIAFNLAVFLSNKLETEFNLKLDEDELGYIAIHFAASNE
                     RMKKNTSKKICIVCHYGIGTGQLISEKLKQNISDLSVVGVYPVRYLDMAISQDVDLIV
                     STVELKGYEKPVLYIENIFDDSLIENVNKAFYEKEERRKIISNMFDEKAFFSIKASTK
                     EEVIISLSNKLKERDFIEESSIKSIIDRENISSTEIGNLVAIPHTIVKGDKKSIIGVG
                     ILENPIIWDKQEVQLVFMVFFNTKEKHNFSIFKYLYNFIKDEGGVRGIIKICDFNKLM
                     ALIGN"
     gene            51635..52090
                     /locus_tag="KR257_000990"
     CDS             51635..52090
                     /locus_tag="KR257_000990"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430982.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIA"
                     /protein_id="HBH0029710.1"
                     /translation="MGTNIFNKEYVFLNVDAKSKVEVLKFISKKAKDLNLAEDESLVY
                     EGLMAREEQFTTNLGESIAIPHTKNDAIENPAVVVLKFNEDVVWNEGEDKVKLAISLL
                     MPGKSKENIHLKLLSSLSRKLINKEFKDSLLKSDNVEEISNLINEALGL"
     gene            52149..52466
                     /locus_tag="KR257_000991"
     CDS             52149..52466
                     /locus_tag="KR257_000991"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_311294.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS fructose transporter subunit IIB"
                     /protein_id="HBH0029711.1"
                     /translation="MNKKLVALCACPMGLAHTFMAAEAIEQAAKALGYEAKVETQGAD
                     GVQNELTRDDILGATMIIHAVAITPEGMERFDGCEVYEVELQEAIKNAEGVIKEIEED
                     LGI"
     gene            52491..53753
                     /locus_tag="KR257_000992"
     CDS             52491..53753
                     /locus_tag="KR257_000992"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728777.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS fructose transporter subunit IIC"
                     /protein_id="HBH0029712.1"
                     /translation="MAIKKKVINSSGASTTGGNNVGKSTPSSPTQSKGNGKWKEISKH
                     IMTGISYMIPVLVMGGLIGALSQLIPYAILGLDPSVGIVDAMNSGEFTGFKLSLLNIA
                     QLMSNFGFTLFGFAIPLFAAFCANSIGGKTALIAGFIGGYIANKPVGVPQFVDGQWTE
                     VVPVASGFLGAILIAFIIGYFVKWLNKSIKVSHNWLAFKTTFLIPLIASLACMVLMIF
                     IITPFGGLINESMKNFLTAAGAAGEYVYATALAAATAFDLGGPINKAAGFVALGLTTE
                     NVLPITARTIAIVVPPIGLGLTTLLDKRLVGRRVYDRQFYQAGKTSIFLSFMGISEGA
                     IPFALERPGFVIPLNIVGSVIGAITGIILGAIQWFPESAIWAWPLVDNLFGYIIGIAV
                     GAIFIAVGNIFYRNKLIKDGKLVVDYID"
     gene            53858..54922
                     /locus_tag="KR257_000993"
     CDS             53858..54922
                     /locus_tag="KR257_000993"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893615.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aminopeptidase P family protein"
                     /protein_id="HBH0029713.1"
                     /translation="MDKIEKVREYFREYDIDGFLINSPTNKFYVGNLFSSSGYVFITK
                     ESQYIIVDFRYFEEIKRKSSLFNVVLMDKTRTHFDIINDICREQNIKEIGFEGNEVSF
                     DLYRSMSNKLSATLKSVDLSTLRETKNEDEIKYIKKACEIVDATFYHIVDFIKVGMTE
                     KQVENEIVRIIKDLGGQKESFDTIVASGLRGALPHGKASEKVIEYGDFVTFDFGAKYN
                     NYCSDITRTICMGTINKELEEIYNIVRKANEECIRVLRPGMTTGEIDKVARDIIGSYG
                     YANNFGHNLGHGVGIMVHEYPALAPESNEVLKEGMIVTIEPGIYVPSLGGVRIEDDVL
                     ITQDGCMRLTTSTKDLIVVS"
     gene            54976..56154
                     /locus_tag="KR257_000994"
     CDS             54976..56154
                     /locus_tag="KR257_000994"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861570.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PatB family C-S lyase"
                     /protein_id="HBH0029714.1"
                     /translation="MYNFDDKPDRVSEKCRKWDLNIIRDKFGDIREDFIPMWIADMDF
                     KIPTEIENKFIEAVRRGVFGYTYCYDEFYDSVIGWQKNMHEVNVEKEWITLTYGTVST
                     LHYVVQAFCKKGDSIILNTPVYDPFESSAKKQGVNVICNTLDVVNDRYYINFDKLEVQ
                     IKENKPKLMMFCTPHNPSGRIWTIEEMTRVATICKENNVILVADEVHAEHIHYGTFNS
                     ILKIGKELLENVILLTSPNKGFNLGGLKTSYSIVINKDIRDKFRNKLKQNSITSPNVF
                     GIIGLITAYNECHEWLSGVNEYIKSNYELLETWVNKYNKIKLMKMESSYLAWMDISGL
                     GISASEFTDKLAIDTGVLLEDGSHFVKDGEKYVRINLGTQKENVIEALNRMDLFLKSL
                     "
     gene            complement(56345..57403)
                     /locus_tag="KR257_000995"
     CDS             complement(56345..57403)
                     /locus_tag="KR257_000995"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893613.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="FAD:protein FMN transferase"
                     /protein_id="HBH0029715.1"
                     /translation="MNKKKITFIFVILILALILFSFFRSSSQNTKYSKTSYYLGTVNE
                     VTVFNVKESKSDKILNECDSILRYIDNKMSTHIPGSDVSKINDNAGKKFVRVSDDTFF
                     VVKEAIQYSKLSDGYFDITIGPLSNLWAIGTDKAKVPSDSKIQKLLPLIDYKNIILDE
                     KNKSIKLTKENMKIDLGAIAKGYAADKIVAYLKSEDVKKGLVNLGGNIFTLENGKNDK
                     PFKIGIQDPTSKNGESIGNIETTNKSVVTSGIYERFIEKDGKIYHHMLNPFTGYPFEN
                     NLSSVTIISDKSINCDALSTSTFGLGLEKGMNLINKIDNVDAIFITKDKKVYLTKGIK
                     DNFKLTDKSFSIEKLNKQ"
     gene            57470..57841
                     /locus_tag="KR257_000996"
     CDS             57470..57841
                     /locus_tag="KR257_000996"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890696.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NusG domain II-containing protein"
                     /protein_id="HBH0029716.1"
                     /translation="MKKKDILLILGILVVITACYGIINVINSKNAGNIEIYVDNKLYK
                     TVSINAKEEFKIESRGGYNIVKIHDKGVEIVDASCPDKVCVHTGFINKPSQSIVCIPN
                     RVSIKINTNEKNDNQEDIISK"
     gene            57878..58552
                     /locus_tag="KR257_000997"
     CDS             57878..58552
                     /locus_tag="KR257_000997"
                     /EC_number="3.2.2.27"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416528.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="uracil-DNA glycosylase"
                     /protein_id="HBH0029717.1"
                     /translation="MVNLGNDWDELLKEEFEKDYYLNLRKFLIEEYKTRQIFPNMHNI
                     YEALKHTSYKDTKVLILGQDPYHGDNQAHGLAFSVQPQVKTPPSLLNMYKELKDDLGC
                     FIPNNGYLMPWADQGVLLLNTALTVRAHEANSHKNKGWEIFTDRVISILSEREDPVIF
                     VLWGSNARKKVELIDTSKHYILEAPHPSPLSASKGFFGCKHFSKINEILKKLGKEPIN
                     WQIENI"
     gene            58801..59640
                     /locus_tag="KR257_000998"
     CDS             58801..59640
                     /locus_tag="KR257_000998"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454771.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="G5 domain-containing protein"
                     /protein_id="HBH0029718.1"
                     /translation="MNFKKLSNAKVSVMAVVLSVGILSGYSALNKQVTLVVRGEERTI
                     STFSSNVGDLLESQNISYDSNDIVTLDENTKLSNGDKIEVIDVKEKTVVETKDIPFEV
                     TVVEDGSLLKGDSKVKEEGKSGKSELIYKETYHNGKKVEKEFVKKVVKAEPVNKVVSK
                     GTKVEMQVASSRGESSRRMASSSSSSSSSNNGKNMRVVATAYTGHSITATGTKPKWGT
                     IAVDPKVIPYGTKVYIPQFDMVFTAEDCGGAIKGNKIDIYMNDSKTVYNWGRKTIDIR
                     ILK"
     gene            59884..59980
                     /locus_tag="KR257_000999"
     tRNA            59884..59980
                     /locus_tag="KR257_000999"
                     /product="tRNA-Sec"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:59918..59920,aa:Sec,seq:tca)
     gene            60135..60842
                     /locus_tag="KR257_001000"
     CDS             60135..60842
                     /locus_tag="KR257_001000"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416532.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA threonylcarbamoyladenosine dehydratase"
                     /protein_id="HBH0029719.1"
                     /translation="MENNFTTRTSFLVGDDGIKKLNNSNIIVFGVGGVGSFTVEALAR
                     AGVGNITIVDFDDVDITNINRQIPALHSTVGRYKVDVMEERILDINPNINIKKIRSLY
                     NKDTSDEILTERYDYVVDAIDMVSSKIHLIETCEKKGLKIISSMGMGNKLDPTKIVVT
                     DIHKTSTCPLAKVMRKELRDRGIKKLKVVYSTEQPIELKKKVMNGRKVTPGSVSFVPS
                     VGGLIIASVIVNELLGQ"
     gene            complement(60984..>61420)
                     /locus_tag="KR257_001001"
     CDS             complement(60984..>61420)
                     /locus_tag="KR257_001001"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861569.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=3
                     /transl_table=11
                     /product="MBL fold metallo-hydrolase"
                     /protein_id="HBH0029720.1"
                     /translation="VLNIDNNINIYVLSPSYIQEESNLNSIVFKLTFNDNSFLFMGDA
                     EEENEKEILHSFKLNNINFIKIGHHGSNSSSSLEFIKKISPDIAAISCGYKNQYGHPH
                     REVINNLKQNHVSIYRTDRIGDIVFYSDGEIIFTKYNYEIDT"
BASE COUNT        23661 a         7112 c        10243 g        20404 t
ORIGIN      
        1 gcaatataaa agcattttgt gatgatacaa atataaatat taaaacattg gaaagaatct
       61 gtttaaaata tacagggtat acacctaaga ttttaaagag aatttacaga tttaaaatgg
      121 caagcaatca acttatttat aattataaag atgatgaact ttttgatttt atttatgaaa
      181 atgagtacta tgaccaagca cactttataa aagaatttaa aaaattttca gggacgtcac
      241 caattaaatt tattggtgag aataagacga ttaaagaaaa tataaagtac agctatttat
      301 aattatactg tcgatttttt acaatacctc caatttattt tttgatatga tataggaaaa
      361 taaattggag gttttacata tgaaaattat tacagaaata gttgagttta atgtggaaga
      421 aaatttatca aaagaagagt ttatagaaat tgtaaatgac ttagaattaa aatttcattc
      481 tattcaatct ggttttattg atactgagct tttatatgat gaaaagtctc aaaagtggat
      541 tatgatacaa cattgggaat ctatagaaga cctcaagagt gcttctagta aaatgtttaa
      601 agattcttca actgagaaat ttagaaaagc tttaaagaat caaactgtta agatgaatat
      661 aataccacaa attaaaagtt ggaaattata gaacttaatg taaaagatag ttaaatagta
      721 tcaaactaaa ttagccaaat aacattttgt atttaaattg ttatttggct tttagtgttt
      781 attttaatat gagtgttata tactagaaaa accaacctta aatactacta tctaaaagca
      841 ctattgctgt acgagaggca ataggcattt tagaagaagg aggagttgag ctaaagtata
      901 catcataatc tcttaagttt tctttttttg tgtttcctcc aaactctacc atatcagtat
      961 ttaatatcgt tttgtagttt gtattttgaa actttgaaat atcaactgat tgtattagat
     1021 tagggtggaa attaaatata aataaatatt tgcccttact gtacaccaaa atctttttat
     1081 cattatccat atgtataagt tcatgactat tttggataaa aatatcactg tattttgtaa
     1141 gttcgagcat agatttatca aaatttaata attgtttata ctttaagttg ttatcttctg
     1201 aaaggctcca ttgtcttctg gcatacttat agctccaatt gttgccttct cgtggaaaat
     1261 caatccactc aggatgtcca aattcatttc ccataaaatt tagatatcct tcacctgcta
     1321 gagaaaaagt tattaattta attaatttaa taagagatat tgctctattg ataacatggt
     1381 tatttgagtt tatttccata ttccagtaca tttccttgtc agctagccaa aaaataattg
     1441 ttttatcgcc aactaatgct tggtcatggg attcacaata tcctatattt ttttctccag
     1501 gtcgtctagt agtaagttca taccacattt ttcccaaatc ccagtcttca tcagataagt
     1561 tagagatagt ttttatccaa aaatcaggta ctcccattgc gagtctatag tcaaatccaa
     1621 ttccgccgtc ttttataggg atacacatac caggcattcc actcatatct tctgcaatac
     1681 ttatcgaatt aggtttaatt tcttttatta attcatttgc aaattggaga tatgttatag
     1741 cttcaatatc tgtattcata ctaaaatatt tttcataact atcaaatgaa actccaagac
     1801 catggttatg atataacatt gaagtcacac catcaaacct aaagccatca aaatggtact
     1861 catttaacca aaattttata tttgaaagca aaaaatgtat tacttcaggt ttaccatagt
     1921 taaaaagttt tgtaccccaa gcaggatgat ttccctttga acctgagtgg aaaaattgat
     1981 gttcacttcc atcaaactca tttattcctt ctaaagtatt ctttacagca tgagaatgaa
     2041 ctaaatccaa taaaacagca atccccattg aatgagcagt gtttatgagg ttttttaagt
     2101 cttcaggagt accaaaccta gatgagattg cataaaagtt tgaaacttgg tatccaaaag
     2161 atgcataata tggatgttcc ataatagcca taagctgaat ggtattgtat ccagcttttt
     2221 ttatcttagg aagtattttt tcagtaaatt cattataagt tccaatagat tcgctttcag
     2281 tagacatacc tatatgacat tcatagatta gtggataagt tatgtttttt aagtcaaaat
     2341 cattgtcagt ccagataaat ggagtttttg gttgccatat ttgtccatta aatccaccaa
     2401 aatctttttg aattactctt tttatatata atggtatacg gtcaaatgtt tttccatttg
     2461 cagtaacttg tacctttacc tctgatttgt gaggtaagct attttgacca ggaataaata
     2521 tttcccaatt accagaccca atttttctta gaggatgaga ttttctattc caattattaa
     2581 agtcaccaat tagtgacaaa ctatctgcat ttggagccca ttccctatag aagaatccat
     2641 catttgtctg atgaaatcca tagtaaagat gagcatttgc aaaagaacta aaatctttat
     2701 agtttttcaa tgtttttgat ttcatattct cataatgttt cattcgcttt tttatatcag
     2761 attcaaatgg ttgtaggtat acatcaatat ctaaaatttt aaatcttttt tgacttttca
     2821 ttgtatttct cctccataat aaatattaca tctaaaaaat aatatttatc tcatactatc
     2881 ttctctatat aattgatata tattatataa tcctaataaa aagcttaagc caccaatgat
     2941 taatttcata atttacctcc ctagtattta tacttatata tcgtattcat caaaatttaa
     3001 aagtttgttt aaaactcttt taataatatc ataatcaaag cctttatagg aaagatgttg
     3061 agaaattttt tgatatattt tctttttatc ttctttcttt actctttcat accttttttt
     3121 tgctagatac atagcatttt caaattcagt gtccttgtct aattcagata ctgcttcatt
     3181 gattgtactt ctattgatac ctttattata taaattctgc ttaattctgt ttttgccaca
     3241 tttatttagg ttaacatttg tgttaacaat tttttgagct aatacactgt catttacgag
     3301 attataactt ttaagaaaat ctatgaccct ctcaattata ttttcatcaa attctgatga
     3361 tagtttttct tttaattttt tttcagattg gtcagcatga gataaaatat ttaatgcttt
     3421 atttttagct tttatataca tttcatcatc taaaataggt tttaattctt cttcatttat
     3481 ttcattcccc ttttttaaat taaatgtata aacaagttct ttaaatatag caataaaaaa
     3541 tttatcatct acataaatat taactctatc atcatttctt ttttgttgtt ctatttttgt
     3601 aattataccc ataagtcctc cttttttata tgtaattata ttaacaaaag caactaataa
     3661 aatttaacaa aaaacttata tttgtatgtt atattttatc aaaattaaga caaaatagta
     3721 aaaagttatt tttattaaaa agtaaagtag aatcatgtta aataattatt tttttaagtg
     3781 ttttttagca tataaatata attatatacc caaaaaaaca aattataagc tttaagaaat
     3841 aaaaaataat ggtacaatag tattataaca ttaaaaggag acaaaatatg agaagtgaaa
     3901 atctagttaa gatggcagag ttgaaaaata ctgaaaaact agagaaattt aatcgccata
     3961 aaggcaaaat caaaataggt atattgggag gtacttttga ccctatacac tatgctcatt
     4021 tagcaacagc agaatttatt agagacaagt atgacattga caaaataatc tttataccat
     4081 caggaaatcc accacataaa ttatgtatca ctacagataa gtatgataga tataatatga
     4141 cacttctagc aactgaaagc aacgaagatt ttttagtttc aaaagtagaa atcgaaagaa
     4201 agaaaaggac ttatacaata gatacattaa aatacttaaa gaaaaaatac aaaaatgcag
     4261 acatttattt tataacaggt gcagatgcaa tttgtagtgt tgaagagtgg aaagatgtaa
     4321 agaaaaactt tgagttagct acttttatag ccgcaactag accaggaatt agtttgttaa
     4381 ggtcacaaga gactatagaa aaactaacta agaagtataa tgctgacatt ataacagttt
     4441 atgttccatc actggatata tcgtccacat atataaggga acagctaaat gaaggcaagt
     4501 caatacgtta cttagtaccc gaaaatgtag aaaattattt atatgaaaat aaactatatc
     4561 aatatggaga tgattaaatg aacttagaaa atattaacca aagactaaat caaatgctac
     4621 cagtggggag gcttagccat tcaaaaaatg ttgcaaaatg tgctgaaaaa ttatgtgaga
     4681 tttatggatg tgacaaagaa aaagcttact tagcaggaat gattcatgat tgtgcaaagt
     4741 atttaagtga caaggaaata gaggattatg taaataagta tgaaatatat ttagacccaa
     4801 tagaggatgg aaatcgttcc ttgtctcata gcgtaattgg ggcgtacata tgcgagtatg
     4861 aatttgaagt agaagatgaa gatattataa atgcaatcaa atatcataca acagggagag
     4921 aggacatgtc tcttttagaa aaaataattt acatagctga tttaattgaa gaaggaagaa
     4981 aattcccagt tgtagataca ttaagagaat tagcatatgg agggaagctt gatgaagcac
     5041 ttttaacttc ttttaataat actttaatgt ttgtcatcaa taaaaaagaa gagatacatc
     5101 caagaacagt tatggcaaga aactatctaa ttaaagaaaa gttattataa aaaagctata
     5161 taaaggcaaa catattaata aatttaaatt tgactatgtt acaaaatcgt attaatatgt
     5221 tacaataact aagtgtattt taattaggaa agtgaggaat ttttatatga cagtggaaca
     5281 aatgacaaaa atagcatatg atgccataga agataaacta ggtcaagata cagttataat
     5341 aaatatagga aaagtttcta gtttgtgtga ttattttatt attactacag catcttctca
     5401 gagacaggta aaagctattg ctgacaatgt ggaagatgaa ttagcaaaac taggattaga
     5461 gccaagaggt aaagaaggac aaggaactca aacttgggta ctccttgatt atggagacat
     5521 aatggttcat gtatttaatg aggaaaatag agggttttat aatttagaaa aattatggaa
     5581 agatgcacct tatatagata ttgacacatt agcataaaca tgataatata tgttattata
     5641 attagaaaat ttcaaaaatt atattaaatt gaatagacta gagcagtaaa agattatatt
     5701 ttttcagaga gttagtggaa ggtgagaact aatattatat aactttgaac ttactagatt
     5761 aaaatctatt ctccatggct ggattaaaag ctatctaaga gagtctatat atgtagtagg
     5821 ctaattaggg tggtaccgcg aagatttatc ctcgtcccta aacgtaagtt tagtgacgag
     5881 gattttttat tttcaaagaa ttatttggaa attataagta aataatacta aataaggtag
     5941 ttatacacaa ttaaaaatag gaggcaaaat atgagcgtat ataattttaa agaagtagaa
     6001 tcgaaatggc aaaaaatctg gaaagataat aatcagtata aaatggatac tgcacaaact
     6061 gaaaaaccta attattacac attagaaatg ttcccttatc catctggaaa aatacacatg
     6121 ggacatgtta gaaattattc tataggtgat gttgtcgcaa gattcaaaaa aatggaagga
     6181 tataatgtac ttcatccaat gggatgggat tcttttggat taccagctga aaatgcagct
     6241 ataaaacatg gaatacatcc gcataaatgg acaatggaaa atatagaaga aatgaaagag
     6301 caattaaatt tattagggat tagttatgat tgggataaag aagttgcaac ttcaactcca
     6361 gaatactata gatttacaca agaaatattt ttgaagtttt tagagcatgg gcttgcatat
     6421 aagaaaaaat catatgttaa ctggtgtcct tcttgtgaga ctgttcttgc aaatgagcaa
     6481 gttgttcaag gagcatgtga gagatgtaaa gcaacagtat taaagaaaga tttagaacaa
     6541 tggtatttta agactactga gtttgcagaa gaattactta atgacttaga tacattagat
     6601 ggatggccag aaaaagttaa aacaatgcaa aaaaattgga taggtaaaag tacaggagca
     6661 gatttagttt ttgatataga tggaactgat aaatctatga cagtatttac aactagacca
     6721 gacacaactt atggagttac ttatatggta cttgctccag agcatgaatt agttaaagaa
     6781 ttggttgcag ggactgaata tgaagcagat gttgaagctt ttgttcaaaa aatgcatact
     6841 atgacagaaa tagaaagaac agcagctgat gtagaaaaag aaggaatgtt tataggtaga
     6901 tatgttataa accctttaaa tggcaagaaa gttcctctat ggatagctaa ctatgtatta
     6961 gttgagtatg gaacgggtgc tataatggca gttccagcac atgatgaaag agatagagat
     7021 tttgctgaaa aatataattt agacataatt gatgtaataa cagaagataa caaaatgata
     7081 aattcagaag aatttaatgg attagatgct tcagaaggat ttgaaggaat aatcgataag
     7141 ttagaaaaag aaggtagagg aaagagaaca attaattata gacttagaga ctggttagtt
     7201 tcaagacaaa gatactgggg ttgtcctata cctgtggttt attgtgatga atgtggaata
     7261 gttccagtta aaaaggaaga tttaccagtt cttttaccaa cagatgttga atttactgga
     7321 aaaggggaat ctccacttac gacttcaaag caatttatgt caacaacttg tcctcactgt
     7381 ggaaaaccag ctagaaggga agttgatact atggatacat ttgttgattc ttcttggtat
     7441 ttcttaagat atgtggatag caataatgaa aatgaaccat ttagtaagga attagttaat
     7501 agatggcatc cagtagacca atatataggt ggagtagaac atgctataat gcatttactt
     7561 tatgcaagat ggtttgtaaa ggcatttaag agtatgggaa tggtagactt caatgagcca
     7621 tttaaaaact tacttactca aggaatggta cttatggatg gttctaaaat gagtaagtct
     7681 aaagggaata cagtatctcc tatggatata atagatgagt atggagcaga tactgcaaga
     7741 cttttcgtat tatttgcagc accaccagaa agagatttgg actggtcaga gcaaggtgtt
     7801 gatggatgct ttagattctt aaatagggtt tatagattgg ttgacgagtt agcagatgtg
     7861 gttaaaaagg atgtagagtt tggagaatta aattcccaag ataaggatat gagatatact
     7921 atacactcta cacttaaaaa agttactgct gatttaagtg aaaaattcgg atttaatact
     7981 gctatatcag ctcttatgga attaataaat gatatgtata aatataaaga gttagataat
     8041 ataaacgaag cagttataaa agaaggtgta caaactatag taactataat tgcaccattt
     8101 gcccctcatt taggtgaaga actatggact atgataggta aagaaggaag tgtatttgat
     8161 atagactggc ctaaatatga cgaaaaagct ttagtaaaag atgaaataga agttgttgta
     8221 caagttaatg gaaaagttag aggaaaatta actgttaact caaatatatc taaagatgag
     8281 atggaaaagg tagctttaga agatgaaaaa ataaaaggat tagttgaagg taaaactata
     8341 gttaaagttg tagctgtacc taaaaaatta gtaaatatag ttgttaaata actcaaaaat
     8401 atgaacaaaa atataaattt ataaaataaa tgaggctgtc tcaaaataga gataagcctt
     8461 ttttcattgt tgaaattata aaaatagatt tgattttata caaaaaaatg attaaagaac
     8521 taaaaagttc attcttatat accctagttg ttgttttaaa tattattata attaatgtta
     8581 aatcgagtta atgtattaag tggtatgtaa atcattcagt ttccaaagtg ttgttcgtca
     8641 aggaactgct ctaagcttaa acgaaaaaaa tataattatt gtattttgaa atttttttct
     8701 atataatgaa aacaggcaaa aaaggtgcat atctatgctt tatatgaaac acccagacaa
     8761 cgaaattcag attcatataa tagctaccat gtttctaaaa aggaacttgt aaaaaagata
     8821 gcgtttcaac ttcccagttg attaaaatta tcagcaggaa aacaagtatg gtcagcagtg
     8881 gtattctaat gggtgttgtc gatatatcca agttgggatt gtctgaggat gttatcaaat
     8941 aacttgtgat aggtgcagta gatgtggaga ttcctgatac ggatttattc tcaggggatg
     9001 gttgcttcgg gagatatgga gcgtaaccag tttattgata tggtaaccat tttttgtcta
     9061 atttgatgaa agaatcccaa gaataccata cagaagtaag acaggaatta actggtggta
     9121 taaactgata aaggcaaatt taaaaatttt gataggatga ttttaagatt tatcttctat
     9181 tttgtttttt agaaataatt gaaatgttat gaggaggtat gtacaaatgg agactgtaac
     9241 aaataatcaa tcaggtgtag aaattcaact cagtctgttt gaagctatca aagatttatt
     9301 gttaattaat cctattttct tgttgggaat tatcttgatt ggtattttct tagttgtaat
     9361 attcaagaaa aatagtgata ttccaaaggt caaaacatct attttatcac tggcaatgta
     9421 ttactactta tgtttaacac tatcgcatat tgttggtata cctacattcg gtgaatatat
     9481 aagactgtca cagttagggg aaacgttctt taatccaaac ataaatctta ttccttttag
     9541 tgatggattt agtttgagtt ttattttgaa tattttactt tttgtcccat taggtttttt
     9601 atgtccgctt ataagcaaaa cctttgaacg tttgagaaat acattcttga ttggttttgg
     9661 attatctctt tttatcgaaa ctattcagct ttttacgtta cacagagcaa ccgatataga
     9721 cgacttactc acgaacgtaa ttggaacaat aataggctat ttctgcttca aactgattgc
     9781 taaattgcga attgtaaaac tacattcaga tgatgactct atggaacagg attacacagt
     9841 atgtattccg attgccatta taatagttgc ccttatatta ggatttttta gttaagttcc
     9901 aaatagctaa tttgggaatc cagacaatat aacagatact atgttacctt ttacaggagc
     9961 atactatctg ttatattgtc aacatcctat tttatggttt gtgtgtagtt tcctgtaaac
    10021 tgaactaaat aattaaatag aagctattag aattaataat aacagataga tattaataag
    10081 cataaacaaa tagtaaaatg tgtagatata gacgttttta agtgaaacta ttataaaata
    10141 attgactgat aatcaactga caaaacctat ttttttaggt ttaactgaca tttaactgac
    10201 agtcagtttt tactatttaa atagaagttc gcttagattg tcggaagctt ctttgtccat
    10261 ttctttaagt acatgagaat atctattcat agttattttt atatctgtat gacccaatct
    10321 ttcagaaaca actttcatat tagttccccc taaaagcagc agagtggcac ttgtatatct
    10381 taaatcatgt attctaatct tttttaaatt attttttttg taaaattgtg aaacgttttt
    10441 cttagtgaag aaggtagaaa cggatttaaa ttggtgttta gacaaactaa gttatttctg
    10501 ttttccagga taccttacaa ttttaatttg ctttgtctta gtttttcaat tttcaatttt
    10561 tcaattaatt cttttggagc tgataaagct ctttttgatt ttggtgtttt tggctcttta
    10621 aaagatattt tgccattaga atagacaaga atttgattaa catttatcag attgttatct
    10681 aagtcaacat ctgaccacct aagcccaata gcttctcaca ttcttaaacc tagaagtaac
    10741 attaaaagaa taggtatttc tatattatta ccaagtaact tttctattag caataatact
    10801 tcttctctat tgtatatttc atttgtagaa tatttttctt tagaaggaag ttttataaaa
    10861 tcacatgaat tttcttgtat ttctcttaat ctatacgctt cccttattac agaacttaga
    10921 aagctatacc ttactttagc actagtaaag gtagaattat taaagttata atttacaaaa
    10981 gcttgtactg aactaggatt tacttctgtg agttttagat tcttaaaaaa ggttctatgt
    11041 aatttttaac ccaagatttt gtatttgtaa cagtatatgg agaccaatta tttttattca
    11101 tgtctatata tttataacat ctttctacaa atgtcatacc ttttggagca acaaacttat
    11161 tattatttat agtagacttt atttcaatta aatgtttttc agcatccttt ttctttttat
    11221 agcttccata acttttttgt ttctttttgc cagtttctta ttccacatat acatagaatt
    11281 tttcccatct ttttcttata aaagctgatt tgatattcat atatgtacgc tccctttata
    11341 agttagtttt ataaaagaac agttggactg ctctaattat gtcattatct ttttaattct
    11401 ttacagttac attataacac gtatttgtat acacttaaat taacaggaag ataaatatcg
    11461 ttaaaggagg aaaagaaaat ttaatgtaga attatgtaag atatatagta tttcatatat
    11521 aaaaggggga gatattgtga aattaaagaa attattatca ctagggttag ccgtgtcaat
    11581 gtttgctgct ggtcctatat cagctaatgc acttgataca atttatacta ttcaaggaaa
    11641 agataaatat gaaacggctg ctcttatagc tgatgaacaa aattatacta cagctatatt
    11701 aattaatgca gacagcacaa tggctgatgg attaagtgcg agtggacttg caggagcaac
    11761 aaatgcacca atttttttaa ctaagaaaaa taacatacct aatgcaactc ttaaaagagt
    11821 agagaaagct aaaaaggtat acataatagg tggagaaagt tctattgata aagcaacaga
    11881 aactcttcta aaagataaag gaatagaggc taaaagactt caaggtagtg atagaattaa
    11941 gacaagctat aatgttgcaa aagaaataaa ctcaattaac aaagtaaata aagttatatt
    12001 gactaatgct tttaaaggag agcctgatgc aatgagtgct gcacctgtag cagttagaga
    12061 taaagcagct atagtattaa ctgatggaaa aagtgttcca tttaatacaa ctggtgtaga
    12121 aagttatgta ataggtggta cttcatcaat gagtgacaaa ctagttaatg atactaattc
    12181 aactagatta ggtggagtag atagatatga tactaataaa aaaatagtaa ataagttcta
    12241 taatggcgca aaagaatttt atatagctag tggtactgat ttagtttatg ctttagttgc
    12301 ttcaccaatg gctaaaaata atcctattgt actagttgat attggaagta ataaagatat
    12361 acttaaaaat gctgcaaaag tgactgggat aggaaatcta agtgataaaa ttatgctaga
    12421 gtgtgaaaat accatcaata atattagtct tccgtcttca aataaaaata taatatgtgg
    12481 attaaagatt gattttgatt caaagcacat aatttggcaa gataaaggaa gttatcttga
    12541 atgttatgat gataaccttg aatattatac tgaaaaatat aaagacccaa cagttcctat
    12601 aaatatagaa aatacaagta cacaaaattt agatgtaaca aaattaaaag tttatggaga
    12661 agctaattca acattatata tggggcaata tgctaaaata aaaatggatt ttaatagttt
    12721 cggtgtatta aagccaggag aaaaatgtac tatttattta gatataattt cattagatcc
    12781 atcaagaagc atgacattaa cattttctta tgtaggtgat aaagaaaatt ataaatatga
    12841 acaaggattg gcaagtagaa tattatttta taacccagat ggagaagatt tttttgaata
    12901 taaataacta gtgggtatgt aaattaataa gggttttata agtttaattt ttttattttc
    12961 gttttatatt aactatgtgg tatgtaaatg tctcgatatt gctcatatgt tgagttatta
    13021 tatttagttt catatgaact atatggattt taaaattaaa aatacttaaa aacatttact
    13081 ttaatagtag gtgttttttt gattaaaaga atattattat aatgtaaaaa gtaataaata
    13141 ggtaaaatat gtaagaatta tatgttataa tatttttagc aagaagatgt aatctacaat
    13201 ttatagagtg gagttcatgt atcaaaaaat tatcctcccg acgctaagaa gggaggtgaa
    13261 tatacatgga taatttttta caaggcatac tagcaagtct atctgctagc ttaatagttt
    13321 atatagctag caaactattt agaaagcgta aaaaaccact caaagcggca actaagagtg
    13381 gttgggaatt tgatttaaaa atcagattcc ataaaactaa gtaatttcta aattatgaac
    13441 tccactctac agcaaaatag attgtagttc ttcttgcttt tattatatca caaattggta
    13501 cagatattca aaaataatat ttttatgata taataaagtc atagaaattt tgcagtgttc
    13561 gattttttga agaaattaag gcttaacagt tgaaatataa ggcattgagg acttgtgata
    13621 agtgttatca attgcactac tcatggttca ctgcaaattt gagagatttg tatatgtgta
    13681 ggcattggaa atactcaatt tattttgggg ttttatatta actatatgga atgtaaatat
    13741 tttttttata tataaacttc taaactttta caaaagtttt atattaacta tatggaatgt
    13801 aaatacactt ccaacaagca ttgtagggtt gaagtctaca ggttttatat taactatatg
    13861 gaatgtaaat taaatcgtat ttataattat atctacactt agtaaatgtt ttatattaac
    13921 tatatggaat gtaaatccaa tagaccctcc aataactcca gatattcctt ctggttttat
    13981 attaactata tggaatgtaa ataatgaact atctaaacca aggtcataat ttaattgagt
    14041 tttatattaa ctatatggaa tgtaaattgt atccaaaaaa ttacaataat catacgaatt
    14101 gctaatataa gcagtcaata tatgtgtaca tttatccatt ttatctctaa acatataaat
    14161 tattatcccc ctaaaaaact ttcataaaaa caaaaagaac aatatctctt tggcaactgg
    14221 ctaacataac tcataagata tttatataag tcttagtccc tatagctttg cgtcactaga
    14281 tttctctagt tttgccgatt tagttttatt ctataactaa ataatacaat agaattagtt
    14341 attattcaac aagattgttt gaaaattgaa taaatttata ggtatgaacg taatttcaca
    14401 cttaaaaaca gactaaatac gtagaatata tagaaaaatt tacctgtagt ttttgtgata
    14461 aaaagctcct attattaatt taagctagat aagtttgagg aagtgacata aattgaaaga
    14521 aggaatatat tatgttgaat aaaaaattac cagatgcaga attaaaaatt atgaaataca
    14581 tatggaatac tggttataaa actgtaatat caaaagatgt tgcagattaa atagaaaaaa
    14641 catatgcttg gaagcataca actacaatta cacttttagc tagattaact aaaaaaggtt
    14701 ttttcatatc gcagagaatt gggaaacatg tacactatag agtattaata aaagagaaag
    14761 aatatctcaa aatagaggga aaaagaattt ttggaggtct acataacaat ccattatcag
    14821 aactaatttc aaaattacat gatggagaag aaataactga agaaaaaata atagaaatag
    14881 gaaattggat aaaaagctgg aaagatgaag attaataaat aaaaggtagc tactaatata
    14941 agtgctacct tttttcttgt ggataatatt ggggataagt tgtggaaaat ttgtgtaaaa
    15001 attgtggata aaatattttg ctgacattta actgacataa gtattagatt ttgatttaaa
    15061 aatgttgaaa tatcaataaa taattaaata gaagttatta gaattaacaa tagattcctt
    15121 tttcaaagaa gtctttgatt tcatcaaggt tatcagtttt tccaagtgct aagataagtt
    15181 ttattctagc tttttgacct ggtaagtccc caccaaatat acaaccaaga ttttttaaat
    15241 ctctaccaga accaaagtaa ccataactat cgaatactct acctgaatga catctagaaa
    15301 ctataactac aggaagtcct ttttctctag catattcaac tccagaaagc atttgaggag
    15361 gaatattacc tctgcccatt gcctcaataa ctataccttt ataaccacta tcaacagcaa
    15421 atcttataaa gtcagcattt tctcctacat atgctttaaa taaggcaact ttagattcta
    15481 ccttatcagt atctataatt gttctattta caatatctct tgtaaggaca agttcgttgc
    15541 agtcaattat tcctaatggg ccactagtta gagatttaaa tgtatttaga gaaagagtat
    15601 ttgttttagt agcttcagaa gctaataata cttcattgtt taaaactaca aggactcctt
    15661 ttcccatagc atctttggat actgcagtac aaactgatgc agataaatta cttgaaccat
    15721 catatccaag ttcagaacta cttctcatag cacctgtgac tattacaggt ttgatgttgt
    15781 caattgtaag gtctagaaaa taagctgttt cctctaaact atctgtacca tgtgttatta
    15841 caacacctgt aatatctttt cttgctaata aatcatttac ataatttttc aattccatca
    15901 ttctataagg tgttatgtga ggtcctggaa tttcatcaaa attaaaaact tcaacatctg
    15961 caactttatc aatgttggta accattgata gtatttgttc acctgataaa gttggtatag
    16021 ctgctccgac tttatcatct actgtcatag atatagttcc accagtaaaa actatggcaa
    16081 cttttttctt aatactcata ctattctctg cctttcataa ataaaattta taattccgat
    16141 aggattatat caaaaaaagt agttaaggtc tacataaact cttttattca tataatttag
    16201 atatttcagt gtaatataat tatttcttaa ttttttgcca ttcaacgata taaccattta
    16261 atatctctct tatggctttt cctatcttag tataagcttc atcatataga tttgctagag
    16321 atattctaat tgaccattca gggccataga atccatttcc actaagtaaa actactgaat
    16381 agtcattagc taatttataa agaacatcta ctggagatgc agttttactt ataaatttaa
    16441 ataagtcttc tccgtagttt aatttagccc attcttcaat atcaaattga gtgtaatatg
    16501 cagcattgtt tttgttttca ttaattggaa gctctaaagc ttcaaataat agtttttgac
    16561 gtctatggca gatactcata ttaagttttt tgtaggcatc tactttgtca atcaatgcaa
    16621 aagcagagaa aaacgccatt tgtacttgct gtggagtaga aagaccagca gtatggttga
    16681 gagcaacaag tctgctatca gcaacaactc tttccataaa ggaaagacta gaagggttaa
    16741 gactcatatc actgtaacgc ttatctactg atttttttaa ttctccagtt aaatcattta
    16801 ttttcttatc aaaaacattt ttcttatgaa gggcaaatgt accaagtctc catcctgtaa
    16861 ctccaaaata ttttgaataa gaatatactc caacagtgtt gtaaggtagt tttgacatta
    16921 aggatgaaaa atcttctaca aaagttccat atacatcatc tgatattatc attaaatctt
    16981 tattataatt ttcaattaca tctattagat tattacaaga tgtttcatcc atagctatag
    17041 aagcaggatt attaggatta acaacgaata aagctttaat agatttgtca cgaagtttct
    17101 ctaattcttt ttttgtatat tgccatgtat gagcaccttt ttcatcaact tcattagcat
    17161 ttatatttac cactttaaag tcgtaacgag gaaggttagg tatttcaaga taaggtgtaa
    17221 atattggagt cattaaggct atggtatctc ctttttttag aagttcattt gccattaatg
    17281 aatcaaatat atagcacata gcagctgtag caccttcaac agcaaaaatt tctacatcac
    17341 catatttacc tgatatatca tatttcattt cttgaactag gtaatcgtgt actatttttt
    17401 ccatatgagg taacattcta tctggaagtg gatagttatc accaataatt ccatcagcta
    17461 gttcatgaac aaattcatct ccatcaaatc caagttcatt tataccaaag tttataatat
    17521 ctctagctaa atatgctcca ggcatatcta tattttcatt tataaattta aaaaatcttt
    17581 ctttaatacc ctttttttga ggcattccag ccaaatgacc taaatcccaa ttagaacgag
    17641 tttcagtaat agcgaaatga ccaaaagtaa aaaaggcttc tctagcagtt gaacaagtcc
    17701 agtttggatt tccacgacct gcatcaagta attctctgtt attttctttt gcagtgtatt
    17761 ttgcaatatc tattaatttg tccttaaatt caaaagggct tatttttcca tatatgtttt
    17821 tgatttcttt ataagtatga tttttcatgt taaattcctc cttatgtaat aagtttcaca
    17881 tttttataat aaaataaaca agttgcaaaa atgattatac tttaattata ataggtttat
    17941 agaaaaagta aagtatgaaa ttaaaataat aactctattt agccttatta aatatatgtt
    18001 aaaataaaaa atacctttta ataaaaaatg attgttatat aaaataaata ttcaatttaa
    18061 ttatcacctt agttttttta ttgtatttta ttatatatgt atagttttct aattttgaat
    18121 aaaaataaag taaaactttc ttttatattg aagttgttta gtaagatatg tattttatta
    18181 atttattaat cttaataatg ttaaataaaa tcaaaaaaat agattttggg taaataaaat
    18241 aatataaaat ataaatttta ataaaaataa taaagtatat attattgctt taataagaat
    18301 gtaaaaaata tttttaaatt atcatttaat gtaatttaaa tgaattgaag atatatgttt
    18361 attgtatgca attgttgtat ttttaggttt tttgtgatta attaaaaaat tataaaaatc
    18421 gtttacatgt tgatttttaa aaaaaaaaga tatagaatta tatagaaagt aataaacaaa
    18481 aattggattt acgggagtgg aatgaaatga tgaatgttac cttaacagat gtaaaagagg
    18541 ctagagagac cattaagaac atagtaaaaa gaactgactt acttgaaagt gttaaactta
    18601 gcgaaaaaac aggagcaaat gtgttctata aatgtgagaa tcttcaaaaa acaggttctt
    18661 ttaaattaag aggagcttgt aacaaaatag cgagtttaac agatgaagaa aaggcaaatg
    18721 gagttatagc ttcaagtgca gggaatcatg ctcaaggagt tgcattggga gcaaaaatga
    18781 ctggtataaa atctacaata gtaatgccag caactgcgcc tttagcaaaa gttagtgcaa
    18841 ctaaaggtta tggagcagaa gtagttttaa atggtgcggt ttatgatgat gcatatgcaa
    18901 aagctgttga aatacaaaaa gaaacaggag caactttctt acatccattc aatgataagt
    18961 atgttatagc aggacaagga actatatctc ttgaaatttt cgaacaatta gacaataaag
    19021 ttgatactat actatgccca gttggtggag gaggaatcat ctctggtgtt gctgttgcag
    19081 caaaagcatt aaatcctaat gtaaaaatag tcggtgttca aactgcaaat ataccttcaa
    19141 tgaaagagtc aataaaaaat ggaaaagtaa caacagcatt taatgatact acaatagctg
    19201 atggtatagc tgttaaaact ccaggagatt taacttttga aataataaat gaattggttg
    19261 atgaaatagt agtggttgaa gagacagaaa ttgcagaatc aatattattt atgatggaaa
    19321 gtcaaaaaat agtttcagaa ggtgctggtg ctgtatgtac agctgctata ttaagtggta
    19381 agtatgtacc agcaaaagat gaaaatgtag tttgtataat atctggtggt aatatagaca
    19441 taaatacgtt atatagaata ataggtgttg ctttagctaa agaaggaaga agatattcat
    19501 ttagtacaat tatggaagat aagccaggaa actttgctga gttaactaga ataataagtg
    19561 agaatggtgg aaacatttta agtgctaatc aaggtaaatt atcagcaggg gaagctctag
    19621 gaaaacaaag tgcggaattt atattagaga caatagatta tgaccatata gctagaataa
    19681 agaaagctat agaagaaaaa ggttttaaaa ttatagaatt ataataaaaa gtgtatataa
    19741 tatacaagaa aaatagtata atagtgtatg aagatacatt ttatgtgtat tagattaacg
    19801 aattaggagg attttaaaat gaaacatgaa gtaatacata ctaatgatgc accagcagct
    19861 ttaggaccat attctcaagc tataaaagct ggaaacttgt tatttgtatc tggacaagtt
    19921 cctcttgtac cagagactat ggaagtagtt gaaggagatg tacaagctca aactgctcaa
    19981 tctttaaaaa atcttaaagc tatattagct gaaagtggag ctgatttttc aaatgtagtt
    20041 aagactacag tatttataaa agatatgaat gaatttgggg ctataaacga agtttatgct
    20101 gaatattttg gagaaaataa accagcaaga gcttgtgtag aagttgctag attaccaaaa
    20161 gacgttaaag ttgaaataga agtaatagct gtattataaa aatacaatat ttttaatttg
    20221 aaaaggctga aaaactatat tctagtgatt cagccttttt ataaaaaaat aaatcacaat
    20281 aaagaacatg ataaatattg tcgaattaaa aaataaaatt aaaataaata ttgcaatatt
    20341 tttgagaagg ttttataatg agtatataat ttgaaacgtg taactattaa attaggcatg
    20401 agttcttgga tatttttatc ctgaggattc atgccttttt tgtattgaaa ttcaaaaatc
    20461 tatttaataa ggaggaagta ctgtgttaaa ttttttcaag aaaaataaaa gctataagtt
    20521 acatgcagta gtgagtggta acagcattaa tattgagaaa gtaaacgatt ctgtgttttc
    20581 aaaaaagtta atgggagatg gagttgcaat tattcctaat agtaatgttg ttgtagcccc
    20641 ttgtaatggt aaagtaactg tgcttacaga atcaaagcat gcctttggta tggtctcaga
    20701 tgagggtgtt gaaatattag tccacatagg aattgataca gttagtttac agggtgaggg
    20761 gtttaaaaat gaagtgtctc aaggagatac tgttaaaaaa ggtagtccaa taataagttt
    20821 tgaaagagaa aaaataaatt ctcagggaat tgattgtaca acaataataa ttgtattaaa
    20881 tcatagcgaa ttttcagaaa taaattgcat ggtagaaaat gaagttgttg cagggcaaga
    20941 tactgttatt gaaattatga aataatagaa agggattaat tcaatatgag agtagtaaaa
    21001 atctttaata ataatgcatt atctacagta actaatgata ggaaagaagc tattttacta
    21061 ggtcttggta taggttttaa taaacgtcca ggagataaag ttaatgaaga taaaatagaa
    21121 aagatttatt atgttcaaga ccacatgcaa acaaaatttt tagaattatt aaaaaatgtt
    21181 agtccagaag tgatggatgc ttcacaacaa attataagtc ttataccagg aaatgaggga
    21241 aaatttaata ataaagggat attatcttta gtggaacata ttagttttgc aatagataga
    21301 atgaaaaata atgttttttt acctaattta atgcttttgg atataaagat gatgtattca
    21361 aaagagtttg aattaggagt aaaagcttta gaaattatat atagagtatg tcatatccat
    21421 ttgcctgaag atgaagcagg ttacatagct ttacattttg tcaatttaca atcaaatgat
    21481 aatttggcat atgatacttt aaaatttgta aaaggtagta ttgatttgat taaagaatgt
    21541 tatggattag aattagacga atcgagttta agtacattac gttttagaac tcatcttaaa
    21601 tttcttgctc aaagaatttt taagaatgaa atttgtcagg atgataaaat gattgaaatg
    21661 tatgattatt taattaacaa tcatcctaaa aataaagaat atttagaaaa gttaaatgta
    21721 tatattgaaa aggagtttag gtataaatta gataaacctg aaaaaattta tctactacta
    21781 cacctaacaa aaatcttata agaatgagat gaattagtaa tagaaatata tataatttta
    21841 gggggggata agattgaaag aaaaactact tggaggactg gaaacatttg caaaggcaat
    21901 ggttcagcca ttaatgtatt tatcgagtgc aggaatatta atggtggtag gtgtactact
    21961 tacaaatgat atgttattag gagtacttcc attttttaaa tgggagccaa ttcaaatatt
    22021 tggaagccta atttataact gtataatggc tattattaat aatcttgctg ttatatttgc
    22081 tataggtatt cctgctgcac tagcaaaaaa agagaagcac aaagcagcgt taataggatt
    22141 tatgagttat ataatatacc ttacagcttc caacactatg ttaacatcac taggtcaact
    22201 agcaaaagaa agcaagatgc ttggactgat agggactgga caagctacta ttttaggtat
    22261 tcaagttgta gatacaagtg tatttggtgg aattatttta gggtatatag ctggatatgt
    22321 atttaatcgt acaagcaaca aaacatttaa aggagcttta cagatatact cgggagcaaa
    22381 ttttagtttt atatgcatgt tctttgtatc cattttaatt ggagttgtga gtaactttat
    22441 atggccatta gctcaacaag gaatagcttc tcttgcaaat gtcatcaaag atacaggtac
    22501 atttggttta ttcttatatg gttttttaga gagaatatta gtaccaactg gacttcatca
    22561 tttaatttat acaccatttc agttttctga tttaggagga gtgcttaaag ttggtgcaga
    22621 tacagtttca ggagcctatg ctatagttat gacagaaatg aatttaccag ttgagcgttt
    22681 ctcagatagt atatactaca tggcaactgg atttacaaag atgtttggtt atataggtat
    22741 aggagctgcc tttatttata ctgcatataa gcaaaataag aagaaggtta aggcaacgat
    22801 tattccacta ataattacgg cagtattagc ctctgtaaca gaaccattag actttatgtt
    22861 tgtattctgt gcaccacttt tattctttgt acatgcagtt atagctggtc tttttatagc
    22921 tttattaaaa atatttgatg ttactgcatt atgtggaggg aacttattag tatcagttat
    22981 aatgaatact acagtaggcg tagaaaaaac acactggcca gtaatgatga tattaggact
    23041 tgcacaaatt attgtatatt ttgtagtatt tagtttttta attaagaaat ttaattataa
    23101 aactccaggt cgtgaagatg agagtacagc tacaggcgaa gaacaatcaa aacaacttaa
    23161 tttagatgca gggatagaaa atataattga tgggttaggc ggaaaagaaa atattaatac
    23221 agtagaaaat tgcatcacta gattacgtgt taatgtaaaa gatgaaagta agattaatga
    23281 agatataatt aatttaacgc caaatagcgg gattgtaagg aaaggaaaag atatacaaat
    23341 aatttttgga cttcatgtgc atgaggtaag acgtgcagta gaagattttt tagaagctta
    23401 ttaaagatat atatttatat agcaagggta aataacagct ttaagtgctg tttactattt
    23461 attaaagata catataattt atagaggagg aataattatt atgattatta ctattgttgg
    23521 tggaggaagc acatttactc caggtattgt taagtcaatt gcattaagag aaaaagagtt
    23581 agagcttgag gaaattcgtt tatttgatat tgataaaaaa cgtcaagata aagtagctgt
    23641 agttgtcaac tggatactaa aagaagatgt taaaacagat gttaaactaa ctgtaactaa
    23701 ttgtgaaaaa gaagcgtata cagatgctac atttatattt gcacaaatgc gtgttggtaa
    23761 atatgaaatg cgtgagcagg atgaaaaaat tccattgaaa tatggttgtg taggtcaaga
    23821 aacttgtggt tgtggaggga tggcatacgg actgcgtaca atacaaccaa tgataaaggt
    23881 tattgatgat gtagagaaat atgctaaaaa agattattgg atattaaatt actctaatcc
    23941 tgctgcaatc gtttctgaag cttgtcgtaa gttaagacca aatgcaagga ttataaatat
    24001 ctgtgatatg ccaatagcta ttatagatat gatagcgggg tcattaaata tcaatgacgt
    24061 tcataatata cgctatgatt attttggtct aaatcatttt ggctggttta cttcaataga
    24121 ttataaacat agagacttaa tggaagagat taaggaatac ataaaagaaa ataaaatatt
    24181 attaccaaaa tcttatatag aaaacttaaa taaaagtcgt agtacaggaa atcgccatgc
    24241 tgtaagtagc tggatacatg tttgggaatc tgtttataca atgttagaaa gcttcccaaa
    24301 atatctgcca aacacttatt taacatacta tcttttaagt aaagaaacag tggaacattc
    24361 aaacataaat cgtactcgtg caaatgaggt tatggaaagc cgtgaaaaag acttatttga
    24421 aggtgtgaga cattacttag aaactggaga aatttctgaa aaagcatttt atgcaggttc
    24481 acatggagat tggattagtg atttggcagt ttcaattaaa aatgatacac gtagtcgttt
    24541 tttagttata actgaaaatc gtggagctat accaaacatg ccatatgatg caatggtaga
    24601 aattccagca tatattggta aagatggtcc agaagttatt gctcgaggtc caatacctct
    24661 atttcaacaa ggattaatga tgcaacaact taacagtgaa aaattgatag tagaagctta
    24721 tatagaaaat agttatgaaa aagctttaca agcattcaca ttaaataaaa ctattccaag
    24781 tatgaatgtt gctaaagaaa ttttggatga aatgatagaa gttaataagg aatactggcc
    24841 agaattaaga tagtaggata aaagaaaggg tttttattta atcattagat atgttttcag
    24901 agtcttttat caaaatgtat tcacaaacat atggcaatat attaaaataa agagtgatat
    24961 ttttagaaga atggggtgat gcaatgaaca ttataaataa aattttttgg caagaagata
    25021 ggattggcat gattacaaat aatttagagg cagatacaca tagccactgt atgttacaac
    25081 tgttcttagg gatagaagac agcattgaaa taacagttaa tgaaaaatta gttaaatgta
    25141 attgtatcat agtagataaa aatatctctc attcattttc agcaagaaaa aaagtttatt
    25201 actctgctat tattgaacct acatctatat atgcagaaca gcttacctca aaaatgaatg
    25261 attttggcta ctggatatgt gacaatgatg gattagagaa attacgtcaa caaggaactt
    25321 ttttgatatc taactctagt aaagaacaat atttaagatt tatggaaatg cttaataact
    25381 atttgaatat acctataact ctcaaacatt atgatgacag aattactgaa ttgttcaatt
    25441 tattacatac ttgtaattgt gataatcata ctatttcaag ttttgcagat aaagtgtctc
    25501 tatcagcaag tagattatca catctgttta aagaacaaat agggatacct ttaaaaagct
    25561 atatcttatt tcatcaaatg gagtgtgctt ttagagaatt actttctgga aaaaatgtta
    25621 ccgaagcttc tatgactgct ggattcgata ctccatcaca ctttgcaggg acagttaagc
    25681 gaatgatggg aatgcctgtt tctttatctt tgaaagatag cgagtttttg aaagtatatt
    25741 aaatattctc gttatataat gaagttgtac taagaaaggg gctttgttat gaataaagaa
    25801 tatttagaag aaacaaaaat gttaaattat aatgaaccac aacttaagct tttggtatca
    25861 tcaaagaatt ggttggaatt agatgatttt cataaaataa aatctattta tgagtttgta
    25921 cagaatgata ttttatttgg atataatgct tctgatatgt taagcgcaac acaggtatta
    25981 aatgatggta tgggacaatg caatacaaaa gctactcttt taatggcatt attacgtgca
    26041 gtgaatatcc cttgtaggct tcatgctttt gatgtaacaa aagattttca acgaggagct
    26101 acatccaaat tgatttcact attagcacca aaatatattc ttcatacttg ggtagaggta
    26161 ttttatcaag ataggtggat tgctctggag ggtgtcataa ctgataaaaa atatttagaa
    26221 gcaattcaga agaaattttt taatcatggt ggaacgttta aaaagtatgc aatagctaca
    26281 aatgatttga aaaatacatc tattgattgg gatggtaaag atacttttat ccaaaaagaa
    26341 gctatcgtgt atgattatgg tatttttcca tcaccagacg tatttttttc tactcattca
    26401 caacatatgt caaaattaaa aaatttcata tatgtacatc ttatcagaaa aataatgaca
    26461 aaaaatgtat gtaaggctag aaacaattat attgataaaa atgaatgagt gtttaagagg
    26521 taactatata ggaaatatat agaataatta aaactgtact ggttaaaatg aataaaaagg
    26581 agttatcaca gagcaaactt aaattgttca taggataact ccttttctgt attaacttct
    26641 aataatttga tgtcttttta taaaacatat agatacaatt aaaccagtaa atgcaagagt
    26701 agctgctatt gaaaatgcaa catctattcc atgaatgtta gacagcatgt ttgaactcat
    26761 atgagctttc ttagtagcac ttgtcattat agtaataagt atagcagaac ctatagctcc
    26821 agatatctga cggagtgtgt tattaattgc tgtggcatga gatataagtt ctctatctaa
    26881 tgttttaatt ccccatgtag ttaatggcat taaaaccatt gaaataccaa tcatacgaat
    26941 acaatacatc aatgacacat gaattaaaga tgtatctctg cctaaaaaag cgaaggataa
    27001 agttcctaaa aacaaacatc ctgttcctaa tattgataga gcatgaggtc catatttatc
    27061 taaatgacgt cctgcaattg gattgagtac aaccatcaat atagcaccag gtaacattaa
    27121 tgaacctgaa gataatgcag aaaatcctct tacagattga acgtacagag gaatcattaa
    27181 tgtagcagac atcattgagg catatacaat cataattaat attgtagaaa taagaaatgg
    27241 tttattttta aaaaccctca attctaaaaa aggttcttta gattttaatt gacgcaatgt
    27301 aaataaaatt aatgacataa ttcctattaa tattggtaaa tatgtggcaa tattagtcca
    27361 cccataatta ccttgattag taaatccaat taataaacca ccaaaaccta gagatgatag
    27421 tactattgaa ggtatatcta attttagttt ttgagtttcc ccaacatttc ttaataaaat
    27481 aaatgatagt ataacatcta atatagcaat aggggaaaga aacagaaata aactatgcca
    27541 accaaatgaa tctactaacc atcctgataa agttggacct attgctggag caaatcctac
    27601 tgtaatacca actaaactca tagctgcacc acgtttttcc tcagggcata aatagagtat
    27661 aataacttgt aaaagtggca ttagagaacc agaacccatt gcctgcaaca cacgagcaat
    27721 caacatagtt gaaaaattat tagaaaaaag tgcaataata catcctatag aaaagataga
    27781 cattgatgta ataaataact ttctagtact aaatcgattt attaaataag ctgttgtggg
    27841 tacaataata cctgcaataa gtagataaat tgttgttaac cactgaccaa catcagcagt
    27901 aattttaaaa tctgacatta tattaggtaa tgctgttgac aatagtgttt gactgagaga
    27961 acttataaaa gcaccagtca ttacaattgc tattattaaa tttccttttt tattgttact
    28021 ttgggtttcc ataatttata acgtctcctt ttttaattga tttttaatgc tgttcaataa
    28081 aagtactttt ggtcttaaag tgtcttcttt ttctaaatat gcaatcattg catccataat
    28141 taaagaatca tattgttgat tttttccctc gacgtataat ttttttattg cttctagtaa
    28201 tttaggattt tcaaggagag aagtatcagt tttgattagt tcttctatat cttgtatcat
    28261 tttaaaaaat agcgatttat tatgaaggga aaagtaaact tcatcttctt gtttatgtaa
    28321 aaacattgat ttttcaatta aaggatttag attatccata ttttctacaa ctaaatctag
    28381 aatttgtata gtaaatttgg caataaagta tacatttatt tctctttttt gtacatgaat
    28441 aatgtatata aactgatgaa ttagagcatc caataagaaa actaaatcaa atataatttt
    28501 ttctatttta tcaccatagt tatcaaataa gcttaatttg tattcattca ataagttagc
    28561 tcgtgatttt gtttgcaatt tacttgtagc cttacgttgc tcttcagaaa aattttctct
    28621 tatataggta tttatggtag ttctagaaaa aatatttttc catacagcaa ttatctttct
    28681 gtttaacttt tctgatgctg gaatgtcatt attttcattt atggaatgta taatttctaa
    28741 aaacttttca tcataataat tgattatttc gcagataaaa ctttccttag tttcaaaatg
    28801 cttgtaaaaa gtagctttag acattttaca ctcttttaca acatccgata ttgaagtatt
    28861 ttgaaaaccc ttttggtcaa aaattttttg tgcaatagtt ataatgagcc tttgtttttc
    28921 tgtcacttta ttatctcctt tcacgcaaaa acgtttagta ctatagagta cctacaagtt
    28981 ttaataaata tattatacat catttggaaa aaaaatcaat atatagactg taatatgaaa
    29041 tttttgaaaa atttgttgtt atttttagtc gtataaaaaa gaaacttaag agtttcttaa
    29101 gaattgttta aagaagttgc aataaattag tggtatgatt atagtatgaa agagaatgtc
    29161 ttgaaatttt tctgtatcaa attccaatta tggaggtgta gtatatgaaa aagaaaattt
    29221 gtgtagcaat aatttttgct ctatttatag tttttgtaga aatgtttatt gatagctcta
    29281 gcgaaggaag taaaattatg acagctgaat taagtaaata caggaaaggc gtaaatgtat
    29341 tatcaataaa caatattata gtagcgaata aaaaatatag tttgcccaaa gattattctc
    29401 ctcaggaaag cagtgaagcg agagatgctt tttataaaat gaataaagat gctcaaaagt
    29461 caggattaaa tttaaaagct tttagtacat atagaagtta tgaatatcaa gatagattat
    29521 ttaagtcata tgtaaaagaa catggagaaa aagaagcaaa tagattttca gctaaacctg
    29581 gagagagtga gcatcaaact ggacttgctt ttgatattgg aggagatgac cagtcttgtt
    29641 gggcaaataa aaagttcaac aatacaaaag aagctaagtg gttgtatgaa aatgcatata
    29701 aatatggttt tatacttaga tatccagaag gtaaagagaa tataacagga tatatgtatg
    29761 aatcttggca ctatagatat gttggaactg aacatagcaa aaactttgca atgaataatt
    29821 tgactttaga agaatattta catataaatt aagagatggt ttgttaaaat taggttaaaa
    29881 taaaaaataa cctagactat tagctgtgta aagtgatata atgtaaatac aatttagata
    29941 actactcgaa ggggagtagc ttacacgaaa gtggtaatta atcgtcaaga cagtagaaat
    30001 actcggttaa ttagcaaggg attccttgat agcaagacct tcaaaataag cattaggtat
    30061 gtttgttttg gggtcttttt ttattcaagg aatttttatt taaaaaaatt taaatttcaa
    30121 gtatacataa gagcccccaa acataaaata aatttattga agaggagggc aacaaatgtc
    30181 ttacaaaagt acttatcaag aagtaattaa aaatttagac tcaagtttat ctggtttgag
    30241 taaagaaaga gcagaagagt tgttagaaaa aaatggagct aatgaattaa aagaagcaga
    30301 taaggttcct acttataagc ttttcctaga aagttttaaa gacccattag taataattct
    30361 attgatagct gctttagtac aaatattttt aggtgaaaca gtggagtcta taataatttt
    30421 tgcagttatt attataaact ctgttctggg tgttgtacaa acaaaaaaag cagaaagttc
    30481 attagaaagt ttgaaaaatt tatctgcacc aaacgcaaag gtaataagag acaataaaaa
    30541 aatgacaatt ccagcaaaaa atctagtagt tggagatatt gtattcttag aagctggcga
    30601 ttacatacca gcagatggaa ggcttataga agcacaatct ctcaaggttg tagaagggat
    30661 gttaactgga gaatcagaac cagttttaaa gcatacagaa aaaataagtg aagatgtaag
    30721 tttaggtgac cagaaaaata tggtatttag tggtgctgta gttgtttatg gtagaggttc
    30781 ttttgtagtg actggaacag gtatggatac tgaaatgggt aaaatagctg ggcttttaga
    30841 aagtgctgaa aataaactta caccattgca acaaaaaata gaggatttta gtaaaaaact
    30901 tggtgtaggt attgtaatac ttgctctttt aatatttata attcaagtag caagaaatta
    30961 ctttatggct ggaaatggag aaatgacaca aattatttta gattcattca tgttctctgt
    31021 agcagtagca gtagcagcta taccagaagc tctatcatca atagtcacta tagtattggc
    31081 tgttggaaca aatagtatgg caaaaaaaca agccataata agaaaattac cagcagtaga
    31141 aactttaggt tcaacaagtg taatatgtac tgataaaaca ggtactctta cacaaaataa
    31201 aatgacagta gttgattatt atatgtatgg aactaataat gatgagttag ataaagaaaa
    31261 agtaaactat tcttatcatg ctaaattatt gactatggtt tctacattgt gtaatgactc
    31321 tcatataact agtgatggta aagaagttgg tgacccaaca gaagtagctt taataaatta
    31381 ttcaagtaaa aatgatttag attatgataa attaagaagt aagtatatca gaataaatga
    31441 aataccattt gactcagaca gaaagcttat gtctactgta aatagtatat atggagatta
    31501 tataatgttt acaaaaggtg ctccagatat tgtgtttagt agatgtaaat atgctttgaa
    31561 aaatggttca aaagtagata taacagatga gataatagaa gaatataaac ataaaaatga
    31621 agagttttca aatagagcac ttagagtatt agcttttgca ataaaagatg tcccagaaga
    31681 agattttata ccttcaattg atgacgaaca tgacatgaca ttggttggaa taatggcaat
    31741 gatagaccca ccaagagaag aagtaatgga tgcagtaaaa gaggcaaaga gtgctggtat
    31801 aaaaactgtt atgataactg gtgaccataa aacaacagca gcagcaattg caaaagagat
    31861 tggtataatg gaagaaggag acttggctct tactggaaaa gagcttgatg ctttgagtga
    31921 agaacaacta tatgaaaaac tagaaaatat aagtgtatat gccagagtct cgccagaaaa
    31981 taaaattcgt atagtaaaag catggcaaca taagaataat ataacagcaa tgactggtga
    32041 tggtgttaat gatgcacctg cattaaaaca agcagatata ggaatcggta tgggaagtgg
    32101 tactgatgta gcaaaagatg cttctgctat ggtattggtt gatgataact ttgcaagtat
    32161 agtaaatgct gttgaagttg gtagaacagt atacagtaat ataataaaat caattactta
    32221 tctatttgca ggaaacttag gagctatagt atccatagta tttgcagtgt ttgcaggttg
    32281 gtcaaatcca tttacagctt tacaactttt gtttataaac ttagtaaatg actctttacc
    32341 agcaattgca ttagggtttg aaaagtcaga aaaaaatata atgaataaac ctcctagaca
    32401 cccggatgaa agtatactag caggaggaac attgaaggca gttgctataa gaggttgtat
    32461 aataggtgta gttacaataa ttgcacaata tataggatta caagtatctc cagaacttgg
    32521 agtagcaatg gcattttcaa cattgatatt agctagaata atgcaaacat tacctgcacg
    32581 ttctaataat caaacagtaa taaaattagg ttttttcagc aataaatacg ttataggagc
    32641 agttttagtc tgtcttgggc tttactcttt aacactaata ccagtgctaa gaggaatatt
    32701 ctctatacca acaacgtttg gattgtacca gttggggatt tgcctagggt tagcattaat
    32761 ttcatcaata ttaatggaac ttaacaaatt aataaataga agtgaagtaa aataatcaaa
    32821 aaattaaagg gcatattgat tttaacaata tgccttttat aaatagtcta atttattcta
    32881 tattatcgat tatttggaat gcttttataa cttcaggtaa ttctttttct tcaggcattc
    32941 taaatcttat gaaattttta tcaagtccag taaaatcact tccagatata actcttattt
    33001 ttaatttagc aaactcttgt tgtaaatcta tgtccttgtt tttatgttca actgtcataa
    33061 ttgatacagt atcactagtt tcagctatat taaggttttt ccatggaatt aataattgat
    33121 tttttatatc ttttgttttt tcttttaatt cttctataaa ttgaacatca tctaataaat
    33181 ttgctgcaat actacgagat atttcagaca cttcgtaagg agtagaaatc tttttaatag
    33241 ggctaacaag ttgttctgga agaactgcat atcctgctct tagtcctgct aaaccgaatc
    33301 cttttgaaaa tgtttttaaa gcaattacat tatcataatt atttagaagc ttgacagctg
    33361 aattttcttt tggcatgtat tcaccataag cttcatctac cataactgct atatcatatt
    33421 tagctgcttc ctttactata ttttcaattg atgataaatg tataatttgt cctgtaggat
    33481 tgtttggatt gtctatgtaa attactttat attctggatt tattttttca ataaattctt
    33541 tttcattaaa cttgaaatta tcctctttct ttaaaagaac ataatcataa gttgcaccat
    33601 gcatttttat atctgtctca tattctgaga actgaggtga atatcctaaa actttatctc
    33661 ccttttcaat aaatagtcta tttaaaaggt aaataacatg tatagaacca tctgccaaac
    33721 aaattctgtc agtatctaat gctataaaat ctttccaata atcgactata ttatctttta
    33781 aagcaattga atgaggatat cctcttatca tatcaaattt taaagcatta aaagcttcta
    33841 cagctttgtt tgagtaagac acggtattta taccttcacc acagtctatc tcgaatacat
    33901 cttctgaatg tccagattct attgcataac tttttttcaa ctgcatttca atagctttgt
    33961 taatttttag tttcatactt tatcactcct tatttagtca ataataaatg ttataaaagt
    34021 tgctagattt aaaatattat gaaaatatat aatagtaaaa aatgaatata aatattataa
    34081 tagctcactt tatttaatat gattatatat catatattgt aaaatttcta gcattataag
    34141 actataaatt gaaaatattc agaaaaatac tacaagaaac gatttatttt gctcttaaaa
    34201 taagttaaat gaatgttatt aattttgtaa attgaaatag tttaagtata aagttatgat
    34261 ataatctaat aagggtaatt ctttagatta tattaaggaa atataggtat acaataaaaa
    34321 gttatggagt tggattatgg gatataaatt aattgtaaca gatatggatg gaactttatt
    34381 aggcaataat cataaagtta cagatgaaaa taaaactgca ctacaaaaag ttataaaaag
    34441 cggtattaat gtaactttag caacaggaag agccttcgat tcagctaaat gcaatgtaga
    34501 ttttcttaaa gaggacatgc caataatagc ttgtaatggt tcattaataa gagagcaaaa
    34561 tggaaatata atatattcaa ataagattga tacaagaaca tgtttaaaca ttttagatgt
    34621 attagataaa tacgatattt actaccaatg taatagtata gattctatgc tttcgaaaaa
    34681 aatagaagga cgtgaagata gattaagtgt atttttaggc tctgaaacag aagtaattgt
    34741 aaaagatgat ttgagagaag aaatctttaa aaaagatata ctaaaatttg taatcataga
    34801 agaaaaaaat ccatctattt tagatgaaat aagaaaagaa ttgagaaaag ttcaaggaat
    34861 aaagataact tcttcatggc caaacaatat tgaagtcatg aatgaaggtg ttgataaagg
    34921 taatgcagtt aaaattttag ctgaaaaaat gaatatagac agagaagata taattgcatt
    34981 tggagacaat tacaatgaca tagaaatgat aaagtttgct ggtcttgggg tagctatggg
    35041 aaatgcagaa gaattgatta aacaagaagc tgattatgtt acagatacaa atcaagacag
    35101 tggagttgca aaggcaattt ataaattcct agagttaaaa gaatcactta gctcttaaaa
    35161 cagtatataa taggaaaaaa taggttgact attttgtaga tagtaattat aatacaaata
    35221 gataaaacat aaaaatttag attcagtgaa aaagagagta gatatagaga aaatctcagc
    35281 gaattggggg atggtgtgag cctaatgata acactttata ttgaaaagaa ctttggagaa
    35341 tactacttga aattcagtat ggtagtaggt aatctcgcct taagagaata gagtgggtaa
    35401 acattgttta ccaactagag tggtaacacg gaatatttcg tctcttggtc tttttgacca
    35461 agagattttt tagtttcatt gagttacaag acttataatt aaaatacaaa aaattaaaat
    35521 atgaggtgaa agttatgaaa ttatggggcg gacgctttag aaaagcggaa aatcaactta
    35581 tggaagaatt taataaatct tttggctatg attgtgtact gtacaaaaaa gatatcgaag
    35641 gaagtgtagc acatgttcat atgcaagtaa aatgtggact tttaacagaa gaagaaggaa
    35701 agtctataac agaaggttta aaagggatac ttgaagatgt agaaaatgga aagttagtat
    35761 tggatggaga gtatgaagat atacatagtt ttactgagat aaatttaatt caaagaattg
    35821 gagatgttgg caagaagctt catacagcac gtagtagaaa tgaccaagtt gcagttgata
    35881 tgagattgta tgctaaagaa aaagcaaatg atttggtggg tttaatatct gaatttaaag
    35941 ctactataaa agatgttgct gacaaaaacc cagtgatgat gccaggctat actcatcttc
    36001 aaagagctca agtagtgaca tttaagcatc acttaatggc atattatagt atgtttgata
    36061 gagatgagaa aagaataaaa aatgctatag aaatattaga tgaatcacct ttaggctgtg
    36121 gagctttagc aggaactacg catgatatag atagaagtat aacttgtgaa caattaggat
    36181 ttaaaaaagt agtagataat tttatggatg gagtaagtga tagagattat ttactagagc
    36241 taatgagtga tttttcaatt ataatgatgc acttaagtag attaagtgaa gagttgatac
    36301 tttggagttc tcaagaattt ggatttgttg agatagatga tttatataca actggaagta
    36361 gtataatgcc tcagaagaaa aatccagatg gtgcagagct tataagaggt aagactggca
    36421 gagtatatgg aaacttattt ggtcttttta cagtaatgaa aggaatacca ttagcatata
    36481 ataaagacat gcaagaagat aaagaaggtt ttttcgatag tgtacatact cttgaaatgt
    36541 gtatacaaat aatggataga atgatagcca cactaaaggt aaatgaggat aaaatgaaac
    36601 aagcagtaaa aaatggtttt ttaaatgcaa cagaagttgc ggattatttg gttaaaaata
    36661 atgttgcttt tagagatgca catggtatag taggaagtat cgttatatat tgtgaagata
    36721 ataaaaaagc aatagaagat ttaacattag aagaattaca taagttttca gatgctttta
    36781 aggaagatat ttatgatttt atcgactatg agagtatatt aaataaggga ataaaaaaga
    36841 atttaaaata atgtatttat ttttaaaagc tgtaaatttg aatgttatca tttaaattta
    36901 cagcttttta ttgtgtaaga ttttattata taaaagtaag aaacttaaaa gtagtagtat
    36961 ttaaaataaa tacaaataaa aaattgttat taaaatgata attaatatca ataagtattg
    37021 acaaaattat ttctaaatac tattatatat aatataaata ataatgaaaa tcaatatcaa
    37081 ataaatggga ggaaatctaa tgaacttatt agtgattggt ggtcatgaaa gaatggaaaa
    37141 agattatatg gttatggcca agaaaaaagg ttataagaca aaggtatata ctaccatgtc
    37201 atctaaatta aataattcta taggaagacc agatgcagtt gtcatactta catcaactgt
    37261 ttcacataag atgtctagaa cggttgagtc tcaagctaaa aaacaagata tattaatcgt
    37321 aaggcataaa aatagtagta aggtagcatt taatgaatgt ctagatatgg ttgatgaatg
    37381 tctgggaaat tgttcaaaat gtaagcttaa agacaaacaa aaacaaaaaa atatataggt
    37441 ataaaaaata cataaacata aaattaaaag tactgagata atagttataa ttattatctc
    37501 agtactttta gatttataag gataagtata ttataaattt tttattataa tttccaacta
    37561 cttgttactt tttcatattt tttttacttc tagctttttt tctttttttc ttctttatat
    37621 ttgaagctat tataaataaa actaaaagca ctagaatacc tgcaataatc ttaacaaaag
    37681 tcattaaaat attatttcca gtaaaaaatg gaagactgct atcaagatta ttttttgcaa
    37741 ttaagtctat actgttttct agtttaccat tattatatac atttaaagta ccaaccttag
    37801 cccctttttt tataggcaaa tcaattttat ttaactctgt tttggtatca taattgcctt
    37861 gagattcatc tttttctaag aatatcctat aactattttt tggttcataa atcaattcat
    37921 gttgttttgt aaacaatact tttttagtat ctgtgtattt ttctttatca acaatagtag
    37981 cacacttaaa gttatcaaat ccataatcaa tcagaatacg tgagtctaaa tataaatcag
    38041 cattagttga attaaataca gcaacgataa ctcttctgcc atcttttaca gcactcgata
    38101 aaagacattt accagcagca tcagtatatc cagtttttat accatcaact atatcatatt
    38161 ttatatttat aggttgacct ttgtatgtaa tcttatcatg tgatgtcaaa aacttattag
    38221 tgtttacaaa gtatctctca taaggatatg cttttgtagc ttcaaattta agtgacttag
    38281 tttttacaat ttgtctaaaa gtatcattat tcatagcttc tctagctatg agagccatat
    38341 catgagctgt tgtgtagtga tttgggtctg gtaatccatg aggattatta aaatgagtat
    38401 tagtagctcc aatttttttt gcctcagagt tcataaggtc aataaatttt tgtacattgc
    38461 caccaccaac atatctagct aatacaaaag cagcatcatt agcagaatga accaaaagag
    38521 catctagtaa ctgctttaca gtaaaagatt ccccattttt tagatacata ctagagccat
    38581 ctatttgagg taaatcttta atttctatta cttgatttaa atctttaacc tcctttagaa
    38641 ctaaacaagc tgtccatact ttagttgttg aagctggata aagcttagaa tttccatcct
    38701 tattatatag tattttgcca gactcatagt ccattaaaac tgcatgttta gcaactatag
    38761 ctggttcatt atctgcaaaa gagatattag agcttcctaa aaatgaagta aatatcaata
    38821 aacagattaa taaaagtgat aaatttcttt tcattgtgag cctccaaatt ttaaattcat
    38881 cttttagtat agcatatatt tgtcaataat taaaagaaag gagtgattaa tatatgaaaa
    38941 aaaaagtaaa atttatttcg ttttttgttt tatttatttt aataatatca tcaataatcg
    39001 tttataaatc gcttattttc aaagatgata tttatgttgt aagtaaaaaa aatttaccta
    39061 atgaaaaaac acatgttgta gagaatgaaa ttaaaggtga agataataat cacaataaag
    39121 taactaaaga catagataaa aattttcaaa ataataaaat aactatatac ataagtggag
    39181 cagtaaatag acctggaatt gtaactatag agtcagacaa gagactttat gatgctgtag
    39241 aattactagg aggaacgaca aaagaagcag atttaaatgg agtcaatcta tcagtaagat
    39301 tagaagatga acaacattac ataataccca aaataggtga agcaacatct gttacaagta
    39361 atgatgattc caataaacca aatcagagga atgagtcaag aggtgagcct aaaaataaat
    39421 ccaataaaaa tatatctaac gaatcaaaag taaatataaa tgtagcgact atagaagagt
    39481 tggattctct acctggggtt ggagaagcta cagccaataa aattttacaa cacagagaag
    39541 aaaatggaca gttcagttca attgaggaaa taaaaaatgt aaatggtatt ggagataaaa
    39601 agtatgaaaa tataaaagat ttaatttgtg tagactaaaa tataatacaa aacttacata
    39661 tagatatgtt attataaata tgtatgtata tgtgtgtaca tgtggaaatt tagtaaagga
    39721 ggcactttta tgaaaaaaga acaaaaaaaa cttacagaga tgacaacagc aggtggttga
    39781 gccgctaaaa tagggccaga ggttctggca tcagttttat ctcaattgcc taaaaatgat
    39841 aatatagaaa atttattagt aggactagat acagcagatg atgctgcagt ttataaatta
    39901 aatgatgata tggcacttat ccaaacttta gacttcttta caccaatggt agatgaccca
    39961 tacgtatttg gtcaaattgc tgcatcaaat tcactatcag atgtatatgc tatgggaggc
    40021 aaacctttgg ttgctatgaa tattgtttgt tttccatcat gccatgatat ggatgtactt
    40081 gcagaaatat taaaaggtgg gtttgataaa gtgaaagaaa gtggagcact tttggttgga
    40141 gggcatactg tagatgacaa agagcctaaa tatggtcttt cagtttctgg gattgtaagt
    40201 ccaaataaag ttttatcaaa tgctactgca aaacctggtg ataagttaat tataacaaaa
    40261 ccaattggag tgggtgtatt aaatacagcc atgaaagaag gtatggtaga acaacatata
    40321 gcagataaag taatagaaat aatgatacat ttaaataaat atgcagcaat gagttttgag
    40381 aaatttgatg taaattcggt tacagatata actggttttg gtctacttgg tcatacttta
    40441 gaaatggcca aagcttctga agtaagtatt gaaattgaat caaaacatgt accaattatt
    40501 gaaggtgcaa tagaaatggc acaaatggga attatacctg ctggtatgta taaaaatatg
    40561 cattatgtat ctaaagatgt agaagttgta ggaaatatag aagttgcagt tcaagatatt
    40621 ttatacgacc cacaaacatc aggagggttg ttaatttcag taaaagaaga acttgcagag
    40681 gaacttgtaa aagatatgaa attaaatgga gcaatagaag ctaaaattat aggttctgta
    40741 gttccaaaag gggaaaaata tattacagtt ttataaaata ttatagagaa agagtgattg
    40801 ttttgagcaa aagagaattg tttgcaatgt tgccttcagt tgatgaagta ttaagtgata
    40861 atagaattgt agaaataata aatgaatatc ctagaagttt agttttagaa tctgtgagag
    40921 aagtaataga tttaaaaaga caatttatat taagattaaa agaagatgca tcaaactctg
    40981 taacaataga gtttggtgaa ataatagaat ctgcaataga gagagttaag ttaaattact
    41041 cattatcttt aaaaaaagtt ataaatgcaa ctggtacagt tattcataca aatttaggaa
    41101 ggtctttact tagtgaagat ataaaagatg aattatggtg tgctgcttca aggtattcaa
    41161 acttagaata cgatttggat aatggagaaa gaggttcaag atactctcat ttaactagta
    41221 caataaaaag acttactgga gcagaagatg tactagttgt aaataataat gcagcggcag
    41281 tacttcttgt acttagcaca atggctaaag gaggagaagc aattgtatct cgtggagaat
    41341 tagttgaagt aggtggttca tttaggattc caagtataat ggctcttagt ggtgcagaat
    41401 tagttgaagt tggttcaact aataaaactc atttgaaaga ttacaaggag gccattacag
    41461 aagatacaaa tgtattgatg aaggttcata caagtaatta tagaataatg ggattcacag
    41521 agagtgtttc tatagaagaa ttggttaatt taggtaaaaa atataaacta cctgtaatag
    41581 aagacttagg aagtggagtt tttatagatt tatcaaaata tggtttatct tatgaaccaa
    41641 ctgtattgga ttctattcga caaggtgcag atgtagtaac ttttagtgga gataagatgc
    41701 ttggaggtcc gcaagcaggt attatagttg ggaaaaaaga gtatatagaa aaaatgaaga
    41761 aaaatcaact tactagagca cttagagttg ataagcttac aatatgtgct cttgaagcaa
    41821 cattgagaat gtatttagat gagacaaaag ctatagaaaa tatacctact ttaaaaatgt
    41881 tgacatataa aattgaagaa ttagaagtaa aagcaaataa actatttgaa aaaataactg
    41941 ctttaaactt aaatgcaaac ataaatatag aagatggatt ttcacaggtg ggaggagggt
    42001 ctatgcctct tgaaactata agtacaaagg taatatcaat aactcctgaa catatgaatg
    42061 tttcatcttt agaaaaaaaa ctaagactta gtgaagcaca tataatagcc agagtgtatg
    42121 ataataaata tgtactagat gtaagaacta tatttgatga tgaatttgat gtaatagttg
    42181 aggaattgag aaaagcattt aattaaataa atttgagtta ataaatatta aatttagaag
    42241 tataagtatg aagttttgat taaaaaatag ctacacacac ttgtgacttt agtcatagca
    42301 ggtttagagg gggcaaaaaa tgaaaaatgt agtaattgga acagcaggtc atattgacca
    42361 cggaaaaact actcttataa aagcattgac tggaagagag actgatacgt tagatgaaga
    42421 aaaaaagaga ggtatttcaa taaacttagg atttacttat tttgatttac caaacaatag
    42481 aagagctgga attgttgatg tcccaggaca cgaaaaattt ataaaaaaca tgttagctgg
    42541 agcatcagga attgatatag ttttacttgt tgtagcagca gatgaagggg ttatgccaca
    42601 gacagttgag catttagata ttctaagctt tttaaatatc aaaaatggaa tagtggttct
    42661 aactaagtct gatactgtag atgatgaatt tagagagcta gtaaaagaag atatttgtga
    42721 aaaaataaaa ggaacttttc ttgaagatgc tgaaataatt gaagttgatt ctatatctaa
    42781 aagaggtata gacactctta ttgaaaaaat agataaaatg agtgatgata tagaagataa
    42841 aaatgaaaac tctccagcaa gacttaatat agacagagta ttttcaataa aagggtttgg
    42901 tactgtaata acaggcactt taatagaagg aaagataagt atagaagatg atttggttat
    42961 atatccacag gtattaaaaa caaaaataag aagtatacaa gttcatggag aaaataaaga
    43021 tacagcttat gcaggtcaaa gaacagcaat caatatatca aatgtaaaag tggatgatat
    43081 aaaaagagga gatgttttag ctgcaccaaa ctcattggag gaatcaatga tgttagatgt
    43141 aaaattatca ttggtaaatc atttagataa aggattaaag cactgggata gattaagatt
    43201 gtatcatgga actagagaga tactttgtag agcagttcca ctagataaag aattaattga
    43261 aagtggagaa agtggctatg ttcagttgag acttgaagaa agcatagtat ctaagaaagg
    43321 tgatacgttt gtagtgagac gttattctcc aatggaaact ataggtggag gtgtaataat
    43381 tgacccatct cctaaaaaac ataagaaatt tgatgaaaaa gttatagaag cattaaaaat
    43441 aaaagaaaaa ggcgaactaa aagatataat agaagagtac ttaaaaagga atttaaaaaa
    43501 ttatccaaat ataaaagaaa taatgagcta tagtggtgct catgaagaag atgtaaaaag
    43561 agcgcttgaa acacttatat cagaagataa agtatttatt ataggaaata tgtatatgca
    43621 tataaatcaa tacaataaat taaaagaaaa tacaataaag cttttaagtg agtaccataa
    43681 gaagtatagg cttagaaaag ggatactaaa agaagaagta aggtctaaga tagagagtaa
    43741 ttttaagact agggagatgg atattttatt agaaaaattg tctacagaaa atgctataaa
    43801 aatagaaaat aatatagtat ctctattaga ttttgaggtt attttaaatg ataagcaaaa
    43861 agaaatagca aaaaaaatag aaaaaagatt aaaatcatgt ggagtttctt ctatactgac
    43921 aatagatgaa gtttctgaag gaaatcataa ctatgctgaa gtattggagt caatgatagg
    43981 taataaagta gagaaattag atgatttgta tataatggac aaagatattt atgaaaatgc
    44041 aaagaacatt ttgataaatt atataaaaga aaataaagaa ataacattag gagaatacag
    44101 agatttgatt gattctagca gaaagaattg catgattata ttggaaaact tcgatagaaa
    44161 caaaataact aaaagagtag aaaacaaaag aattttgttt tagcagaaaa tgtctgtttt
    44221 tgctttaagg tataaagaag gaattataat gtcgagtatc gtataattaa ttagtataaa
    44281 atattaatta agaggaagtg taaagtattg aagaatataa tacctgatgt aaaaccagat
    44341 ataaaagaaa gagaagacat gagcctttta tttataataa tgggctcagt acttttatta
    44401 tttattataa aagatataga gaaatatgaa actttattac atgccatata tacgatattt
    44461 ttagtagcta caggagtaat tatatttaat actacaaaat ttaaagtaga ttcattttct
    44521 acatttttag gattaatttt tatagctact ggagtattgg agtgtatata tttatttaat
    44581 tccttgggga ttaaaactaa gtctataatg gagattaaca tcacaatatc agcaataaca
    44641 gatttatttc ctatactggg tgtatactta agttttaaat ttgttaagga taacaaacaa
    44701 atttattcaa gtgtaatttt atttatagca actgctacat taacaataac atctttattc
    44761 ataatatcag gaatttgtga ctatctggga aatggtaaat cacaatatgc tttaggagtt
    44821 ataatatcta tattcataat aattatttct atcattagtg gaattgaatt aaattcaagt
    44881 tcaaataaag gtaaatggga atatgatgaa aaaaagattt ttaacagaat aatagtaata
    44941 ataatcttat caagagttcc aaatctattg catatagtta ttgataatag aaatgtagag
    45001 aggatattat cacaaataat aataaatgta gccttatatt atttatataa ttacatagta
    45061 tctaagaata ttaagaaaac agcactggaa ttgcatgata cgaatgaaga attaacaaaa
    45121 aaaacggaaa gtttaaaaga aaagaataaa aaattaatct atgagacaga aaagatagag
    45181 gaacttaagg gaatacttat gaaaagagaa tctaggctac aatctacatt agatgtagca
    45241 gtaaatagca tagtagtatt tagcaaagat ggagaaatta catatgcaaa taagagcttt
    45301 agaaatactt ttggagacta taaagaacaa gataaattga ctgataaaat aaaaaacttc
    45361 aatgatttga tagaaagcat tcattatgtg tttgttcatg agaagaatgc agagaaactt
    45421 attagtacaa gcgataataa agtttatcaa gctatatttg cacctttaat tattgcttca
    45481 caaacagaag gagtattgtg tgtactagaa gataagacta agaaaaagga gtacgaacgc
    45541 aaacttattg aagcaaataa gagaagtaaa gattttttag aaagtattgg agatggcata
    45601 gtagtgcttg aaggtaataa caaaatatat gttaataatg catgtaggga aatttttaaa
    45661 aataatttag agagtattga tttttcatta gtatgtaaaa gtgaagaaag tatagaaaaa
    45721 agatatgtaa tagatggtga agtaaagtat gtagagatga gtttttctca gtatactaat
    45781 gctggtacta ataaaactat tattgtaata cgtgatacaa cctctcgaaa aatatctcaa
    45841 ataaaacttg aggaaagtca atcatcatat tcaagattta tagatatatt acctgatggc
    45901 atatgcttat taaaagaaga tttaagtata aactatgcaa ataagtcgtt tttagatatg
    45961 ctagctttta caaacataga tgatataaaa gattctaata ttaaactatt aatgaatgcg
    46021 aatactgaag aaaaaatgaa atttacggat aatatggcta aagttttaaa tgaaaataga
    46081 agtatacttt tactggaata tgaattgata aatagttatg atgatatagt agaagtagaa
    46141 ttaagtgcat taccttttgc tatatacaat actagataca taatgcttat tataaaagat
    46201 ttagtacata agaaatattc cgagcaagca gaaaaagaac tgcttgaaag atttaaaaca
    46261 gataaaatca aaacggagtt ttttgcaaat atgtctcatg aactaaaaac tccactaaat
    46321 gttatatcta gttcaaatca actggtagat tctttctata gaaatgaaaa gataaaagat
    46381 tacaataaca atattaaatc tcatgtggat ttagttagac aaagttctta taggcttcaa
    46441 agattaataa ataacattat agatttaaca aagatggagt ctgggttcta tacactaaaa
    46501 cttgcgaaat acaatattgt atctgtaata gaagacttat ttatgaatat agaagagtat
    46561 gcacttagaa aagacataaa aattcttttt gatacagacc ttgaagaaat taatgtttat
    46621 atagacaagg ttgaaattga gagaattatg ttgaatctat tgtcaaactg tattaagttt
    46681 actgataatg gaggctggat atatgtaagt attcattata aaatagataa agtaatcata
    46741 agtgtaaaag acactggagt tggaatacca caagataaat tagagttgat ttttgaagaa
    46801 ttttcacaag ttgataagac tttatccaga aatactgaag gaagtggaat agggcttgct
    46861 atagttaaga atctagtaag tcttcatggt ggagatatag aagtagtaag tgaagtgaat
    46921 aaaggcacag agttcttaat ttcacttcca atgaagggat ttagtagtga acattacaca
    46981 gaagataaga gaatatataa tattcaagaa aaaataaaaa tagaattttc tgatatatat
    47041 tattaaaaat gattatgagc aaaaataaaa taaaaatact atttgtttaa atatttaagt
    47101 tgtaagaaat aggctatcat aaggtaaatt attatgatag cctattttta gctaggtttt
    47161 atatctatat gtgagaacat ataatctcta aattaccttc aaaactaaaa tctccaaagt
    47221 cgtttggtag tataaaatgc ataccctttt ttaaattgta ttctacagaa ttgtgtataa
    47281 gttttccatt tccatccaac acactgtata aagaaaaagg tgtattgtgt gtaaaattac
    47341 attttccaaa aacatctaat ttataaacac taaaaaattc gtttgacaca aatgttgtgc
    47401 atttaaagtc tgatgttgat acgattttat agtcagtatc gaaatttata tgaggaacat
    47461 tcgtaacatc tattgatttt tgaacatgaa gttcacgctt attacctgaa ttgtcagttc
    47521 tatcataatc atagactcta taagtagtat ctgagttttg ttgagtttct aaaatcaatg
    47581 ttcctttgca tatagcatgt atagtgccac ttggaacata gaaaaagtct ccctttttta
    47641 tattaacctt tctaagtagt ttgtcccatt cattattatt taccatattt acaaattctt
    47701 tatgagattt tgcattatga cctattataa tttctgcatc atcagaacaa tctattacat
    47761 accaacactc tgtcttacct aactctccat tttcattttt tttagcatat tcatcatttg
    47821 gatgaacttg aactgataaa ttatcatttg catccaatat ttttgtaagt aaaggaaact
    47881 tatcaccagg tgtgtttcca aataattctc tatttttatt ccacaattca gatagttttt
    47941 tacctttata ttttccattt tctattaagc aatctccatt tttatgagag cttatagccc
    48001 aacattcacc agttgttggc gaatctattt cataattaaa tttatcttta agtgcagtac
    48061 caccccatat tctatccata aaaataggtt ttaaaaataa tggttccata atcctgttcc
    48121 tcctatgata ttaaatttat cctacaaata attatatata aatagattat aaaatcaata
    48181 gtaaaaaagt tttgtccctt gaaatgacat aaagtataag gagttattaa ataagataaa
    48241 ctatgatata taatataaag ttctaaattg gagtgataat tatggagttg tttaaggcag
    48301 aaagcaaaaa atataaaaaa gaatttttaa aattattgga gcaatgggtt agtatacctt
    48361 cattttatga tagaaaaact gtatctaaag acatgccttt tggaaaagga gtatatgatg
    48421 cattaaactg gtttgaaaat ctaggtagag aaaacaattt caaagtaaaa aatatagata
    48481 atcatgctgt tcaaattgaa tatggaaatg gtaaagagta tgtagatata tttggacatt
    48541 gtgatgttgt aaatccaggt gaaggatggg atagtgaacc atttaaacta aatattatag
    48601 gtgataaatt agttgctaga ggtgtatctg ataataaagg gcctatgata gtgaattttt
    48661 tagcactaaa aatgataaag gatttagata ttaatttaaa aagaaaggtt agattaatag
    48721 ctgggggaaa tgaagagagt ggatttaaat gtataaagca ttattatagc aaagagccat
    48781 atggtgtatg tggatttact ccagatgcta aatttcctgt attaaatgga gaaaaaggtg
    48841 gagcaataat aaagttaatt tcaaatatag acgataaatc tttatatata agtggtggaa
    48901 tagagtttaa tacaatacca gataaagttt atataaagaa tgtagaaaaa ttgggtaaag
    48961 ataatatatg ttttgatatt aacaatatat cgataaatta tgataatggc aattatattg
    49021 tgtatggaaa aggtggtcat tcatctaaac ccgaaaaatc aataaatcct atattagcta
    49081 caattaaact tttgtcagaa aatattgatg aaaaatggac aaaagattta tataagttga
    49141 taaatcaaga taatataaat ggaaacttat ttggtttaaa tattgagggg aaatgtggaa
    49201 ttttatcaat ggtgccaaca ataataaata tagtagatgg aaaattagaa gtagttttaa
    49261 gcgttagata tccagaaata ttaaccattg aagatataat aaaaaaattt aatttgtata
    49321 tggagcaaaa taatattaat aaatttgagc ttattgggga aaatttaaag caagcaaatt
    49381 atatagatag aaattcaaaa cttgtaagaa gtttgcatga tatatatata aagtattctg
    49441 gagatttaaa aaatgatgtt agagtaacta gtgcaggaag ttatgcttct gaaatgaata
    49501 attcagtaat atttggttgt gaatttcctg atggtagctt tggcaatgtc catagtgcga
    49561 atgaatttgc tagcttagat agatttataa ctgcaatagg tatatatgca gaggcaataa
    49621 ttacattatg taataaaata taaatacaaa atgtccctta tatagacata ttatatatac
    49681 aattaaaatt ttacttgata tataattgaa atcaaagaga aggtgataca atgataacta
    49741 agaaacatgc aataatagta aagagtttaa gcaataaaga tggatatatg acatcaaacg
    49801 aattagctat caaattggat gtgtctacta aaactattaa aagatatata gcagatttaa
    49861 atagtgtttt aagcaaatat gatttggtaa tagcttcttc tagaggtata ggatacaagt
    49921 taagcggttc taaaaacaat atagccagag ctgttaaaga agcaaataaa tatattgatg
    49981 gttttttaga tgactctgaa gagtcaagaa tgtcaaatat aatatgtatg cttattaata
    50041 gaaattatat gagtatagaa gcaatggcag aagaattaaa tctaagtata gccgctataa
    50101 ataaattgtc tagtaagctt aaaagaaaac ttgaaaagta tgacttagtt ataaaatcta
    50161 aaccttacta tggaagctat atacatggtg aagaaattaa tataaggcaa ttaattactg
    50221 actatgcaat aaaattagat gaaaaaagta aagtgaaggt gtttttagat gacattagtg
    50281 aaaacgatat acactgtata gaaagtattt tagaaaagca cttaagagaa aaagatacaa
    50341 taatttcaga taaagatttt aatcttttgc tttcaaaaat aatcgtttct gtatttagga
    50401 gtaagagagg tcatagtaac aatataaact taatggatac aagttataga tttcataact
    50461 actactttat agaaaatcta atgaaagaaa tatctgataa aattggattt aaacttattg
    50521 aagatgaagt aatttatatt tcaaattatt ctggtgtaat agcctataaa ggtacacaag
    50581 gaagaaaaaa cacaagtgaa attgaggaac gaataagtac tgttataagt agtgcacttc
    50641 aagatatatt ccttatttca ggtagtgatt atacaaaaga tgatgagttt atggttgcaa
    50701 tctctgacca tataaagaga tttttaaata gagctagagc taatgtaaaa tcaaataatc
    50761 ctttacttca tcaaataaaa gagaagtttc ctatagcttt taatttagcc gtgtttttat
    50821 caaataaact agaaactgag tttaatttaa aacttgatga agatgagctt ggatatatag
    50881 ctatccactt tgctgcttca aatgaaagaa tgaaaaaaaa tactagtaag aaaatttgta
    50941 tagtttgtca ttatgggata ggaacaggac aacttatttc tgaaaagcta aaacagaata
    51001 taagtgattt aagtgttgtg ggtgtttatc cagttagata tctcgatatg gctataagtc
    51061 aagatgttga tttgatagta tctacagttg aattaaaagg atatgaaaaa cctgtcttat
    51121 atatagaaaa tatatttgat gatagcttaa ttgaaaacgt aaacaaagcc ttttatgaaa
    51181 aggaagaaag aagaaagata ataagtaaca tgtttgatga aaaagctttt ttcagtataa
    51241 aggctagtac taaagaagag gtcataattt cactttcaaa taaactaaaa gaaagagatt
    51301 ttatagagga aagttctata aaaagtataa tagatagaga aaatatttca tcaactgaaa
    51361 taggaaatct agtagcaata ccccacacaa tagtgaaggg agataaaaaa tctataatag
    51421 gagttggaat acttgaaaat ccaataattt gggataagca agaggttcag ctagtattta
    51481 tggtattttt taatactaaa gaaaaacata atttctcgat atttaaatac ctttataatt
    51541 ttataaaaga tgaaggagga gtaagaggaa ttattaaaat atgtgacttt aataaattaa
    51601 tggcacttat aggtaattaa ggaggaaatt aataatggga acaaacatat ttaacaaaga
    51661 atatgtattt ttaaatgttg atgctaagtc aaaggttgaa gttttaaaat ttatatcaaa
    51721 aaaagctaaa gacttaaact tggcagaaga tgagagctta gtatatgaag gtttaatggc
    51781 tagagaagaa caatttacta caaatttagg agaatctata gcaatacctc acactaaaaa
    51841 tgatgcaatt gaaaatccag cagtagtagt attgaagttt aatgaagatg ttgtttggaa
    51901 tgaaggtgag gataaggtta aattagcaat aagcttactt atgccaggaa aaagtaaaga
    51961 gaatattcat cttaaattat tatcatctct ttcaagaaaa ttaataaata aagaatttaa
    52021 agattctctt ttaaaaagtg ataatgttga agaaatatct aacttaataa atgaagcttt
    52081 aggtttataa ttaaacacta aggttataaa ataaaaaaat aattaactaa aaataggagg
    52141 aatttgaaat gaataaaaaa ttagtagcat tatgtgcttg tccaatggga ctagctcaca
    52201 ctttcatggc agcagaagca atagagcaag cagcaaaggc attaggttat gaagcaaaag
    52261 ttgaaactca aggtgctgat ggtgtacaaa atgagttaac aagagatgat atattaggag
    52321 caactatgat aatacatgca gtagcaataa caccagaagg tatggaaaga tttgatggtt
    52381 gtgaagttta tgaagttgaa ttacaagaag ctataaaaaa tgcagaaggt gttataaaag
    52441 aaatagaaga agatttagga atataataaa tttattgtgg aggaaataga atggcaatta
    52501 agaaaaaagt tataaacagt tcaggtgctt ctacaacagg aggaaataat gtaggaaaat
    52561 ctactccatc tagtccaact caatcaaagg gaaatggaaa atggaaagaa ataagtaaac
    52621 atataatgac aggtatatca tatatgatac cagttttagt aatgggtgga cttatagggg
    52681 ccttatctca attaatacca tatgctatat taggacttga cccatctgta ggtatagttg
    52741 atgctatgaa ctcaggagaa tttacagggt tcaagcttag tcttttaaat atagcacaat
    52801 taatgtcaaa tttcggattt actttgtttg gatttgcgat accactgttt gcagcatttt
    52861 gtgcaaactc tataggtgga aaaacagctt taattgcagg atttataggt ggatatatag
    52921 ctaataaacc tgtaggtgta ccacaattcg ttgatggaca atggactgaa gttgttccag
    52981 ttgcatcagg atttttaggt gcaatactaa tagcatttat aataggatat tttgtaaaat
    53041 ggttaaataa atctataaaa gtttctcata actggttagc ttttaaaaca acatttttaa
    53101 taccattaat agcgtcatta gcttgtatgg tattgatgat atttataata actccatttg
    53161 gtggattaat taatgaaagt atgaaaaact tcttaacagc agcaggagca gctggagaat
    53221 atgtatatgc aacagctttg gcagcagcta cagcattcga cttaggagga ccaataaata
    53281 aagcagcagg attcgttgca cttggtttaa ctacagagaa tgtacttcca ataacagcaa
    53341 gaacaatagc tatagttgtt cctccaattg gattaggatt aacaacatta ttagataaaa
    53401 gattagtagg aagaagagta tatgatagac aattctatca agcaggaaaa acttctatat
    53461 tcttatcatt tatgggtata tctgaaggag caataccatt tgcacttgag agaccaggtt
    53521 ttgttatacc tttaaacata gttggaagtg taataggagc tattacaggt ataattctag
    53581 gagcaattca atggttccca gagtcagcta tatgggcatg gcctctagta gataacttat
    53641 ttggatatat aataggtata gcagttggtg ctatattcat agcagtagga aatatattct
    53701 atagaaataa attaataaaa gatggtaaac ttgttgtaga ttatatcgac tagtatttaa
    53761 tttttactat ctataaataa ctttggctgg taatatggtt ttaatcaata ttaccagcct
    53821 tacctatatg attaattaaa ggcggtggag ataagatatg gataagatag aaaaagtaag
    53881 agagtatttt agagaatatg atatagatgg atttcttata aatagtccta caaacaagtt
    53941 ttatgttgga aatttattta gctcttcagg ttatgttttt ataactaaag aatcacaata
    54001 tataatagta gattttagat attttgaaga aattaaaaga aaatctagtt tgtttaatgt
    54061 agtattaatg gacaaaacta gaactcattt tgatataatt aatgatattt gtagagagca
    54121 gaatataaag gaaattggat ttgagggaaa tgaagtatct tttgatttat atagaagtat
    54181 gagtaataag ttaagtgcaa ccttaaaatc agttgattta tctacattaa gggaaacaaa
    54241 aaatgaagac gaaataaaat atataaaaaa agcttgtgaa atagttgatg ctacatttta
    54301 tcatatagta gactttataa aggttggtat gactgaaaag caagttgaaa atgaaattgt
    54361 tagaattata aaagatttag gtggtcaaaa agaatctttc gatacaatag ttgcatctgg
    54421 gcttagagga gcattacctc atggaaaagc aagtgaaaaa gttatagagt atggagattt
    54481 tgttaccttt gactttggtg ctaagtataa taattattgt tcagatatta ccagaaccat
    54541 ttgtatgggt actataaata aagagttaga agaaatatat aatatagtaa gaaaagctaa
    54601 tgaagagtgt ataagggttt taagaccggg aatgactact ggagagatag ataaagttgc
    54661 aagagacata attggttcat atggatatgc caataatttt ggtcataatc tgggtcatgg
    54721 tgtaggaatt atggttcatg aatatcctgc attagctcct gaatcaaatg aagtattaaa
    54781 agaaggaatg attgtaacta tagagcctgg tatatatgtt ccaagtcttg gaggcgtaag
    54841 aatagaagat gatgtactta taacacaaga tggatgtatg agattgacta catctactaa
    54901 ggatttaata gttgtaagct aaaaataaat tagataaata ttttataaca ataagaaaag
    54961 aagaggtaaa tttaaatgta taattttgat gataaaccag atagagtaag tgaaaagtgt
    55021 agaaaatggg atttaaatat tataagagat aaatttggag atattagaga agattttata
    55081 ccaatgtgga ttgctgatat ggattttaaa ataccaacag aaatagaaaa caaatttatt
    55141 gaagctgtaa gaagaggtgt atttggatat acatactgtt atgatgaatt ttatgattca
    55201 gttattggtt ggcaaaaaaa tatgcatgag gtaaatgtag aaaaagaatg gattacatta
    55261 acttatggaa ctgtatcaac acttcattat gtagtacaag ctttttgtaa gaaaggtgat
    55321 agtataatat taaatacacc agtttatgac ccctttgaat catcagcaaa aaaacaaggt
    55381 gtaaatgtaa tttgtaatac attagatgtt gtaaatgata gatattatat aaattttgat
    55441 aaattagaag ttcaaattaa agaaaataag cctaaattaa tgatgttttg tacaccacat
    55501 aatccatctg gaaggatatg gacaattgaa gaaatgacaa gggtagcaac tatatgtaaa
    55561 gaaaataatg ttattttggt tgcagatgaa gtacatgcag agcatattca ttatggtaca
    55621 tttaattcaa tacttaagat tggaaaagag cttttagaaa atgttattct attgacatca
    55681 ccaaataaag gatttaatct tggtggatta aagacttctt attcaatagt tataaataag
    55741 gatataaggg acaaatttag aaataaatta aagcaaaatt ctataacttc tccaaatgtg
    55801 tttggaataa taggattgat aaccgcttat aatgaatgtc atgagtggtt aagtggtgta
    55861 aatgaatata taaaatcaaa ttatgaactt ttagaaactt gggtaaataa atataataag
    55921 ataaaattga tgaaaatgga atcatcttac ttagcttgga tggatataag tggattaggt
    55981 attagtgcaa gtgagtttac agataaattg gctatagata caggagtatt attagaagat
    56041 ggaagtcatt ttgtaaaaga tggtgagaag tatgttagaa taaatttagg aactcaaaag
    56101 gaaaatgtaa ttgaagcctt aaatagaatg gatttatttt taaagtcttt ataaaaattt
    56161 ggttgaatta gtattttata taaatttaaa ctattaatat ggtatataca taagtagaat
    56221 ttgttttaga ttacttaagt atataccata ttttatataa aaattaaatt tgcattagtc
    56281 atgtgataac tatttaaatt catatgtatt ttgtatgtat aatagatata attattattt
    56341 aaacttattg tttatttaat ttttcaatag aaaaagattt atctgtaagt ttaaaattat
    56401 cttttatacc cttagttaag tatactttct tatccttagt tatgaatata gcatctacat
    56461 tatcaatttt attaattaaa ttcatacctt tttcaagacc aagaccaaat gtagaagtgg
    56521 ataaggcatc acaattaata gatttatcag agattattgt aacactactt aaattgtttt
    56581 caaaaggata ccctgtaaat ggatttaaca tatgatgata tatttttccg tctttttcga
    56641 taaatctttc ataaattcca gaagtaacaa cagacttatt tgtagtttct atgtttccta
    56701 tggattcacc atttttacta gttgggtctt gaatacctat tttaaaaggt ttatcatttt
    56761 taccattttc taaagtaaat atatttcctc ctaagtttac taaacctttt tttacatcct
    56821 ctgattttaa ataggctaca attttatcag cagcatatcc tttagctatg gcacctaaat
    56881 caattttcat attttctttg gttaatttta tagatttatt tttttcatcc aatatgatgt
    56941 tcttataatc aataagaggc agaagttttt gtatcttaga atcacttgga actttagctt
    57001 tatctgttcc aatagcccat aaatttgata atggaccaat tgttatgtca aaatatccat
    57061 ctgataattt ggaatattgt atagcttctt ttacgacgaa aaatgtatca tcagaaactc
    57121 tgacaaattt tttaccagca ttatcattta ttttagaaac atcacttcct ggtatatgag
    57181 tgctcatttt gttgtcaata tatcttaaaa ttgaatcaca ttcatttaag attttatcac
    57241 ttttggattc ttttacatta aatacagtaa cttcgtttac tgtaccaagg tagtagctag
    57301 ttttactata tttagtattc tggcttgaac tcctaaaaaa tgaaaataaa attaatgcta
    57361 aaatcaatat cacaaaaata aatgtgattt ttttcttatt catggtatat tcctcctatg
    57421 aaattgtgtt attattttat tataacataa tttcatagga ggacaaaaaa tgaagaaaaa
    57481 agacattctt cttattttag gcattttggt tgttattaca gcatgttatg ggataataaa
    57541 tgttataaat tctaaaaatg ctggaaatat tgagatttat gtagataata aattgtataa
    57601 aactgtttca ataaatgcca aagaagaatt taaaatagag agtagagggg ggtataacat
    57661 agtaaagatt catgataaag gggttgagat agtagatgct tcatgccctg ataaggtttg
    57721 cgtacatact ggatttataa acaagccaag tcaaagcata gtttgtatac ctaatagagt
    57781 gagcataaaa ataaatacaa atgaaaagaa tgataatcaa gaagatataa tttctaaata
    57841 aaataataaa aataattgaa aggaattggt gataattatg gttaacttag gaaacgattg
    57901 ggatgaatta ttgaaagaag aatttgaaaa agattactac ttaaacttaa gaaaatttct
    57961 tatagaagaa tataaaacac gccaaatttt cccaaatatg cacaatatat atgaagcttt
    58021 aaaacacact tcatacaaag acacaaaagt cttaatatta ggacaagacc cttatcatgg
    58081 agataatcaa gctcatggtt tagctttttc agttcaacca caagtgaaaa ctccaccatc
    58141 tttattaaat atgtataaag aattaaaaga tgatttaggt tgttttatac ctaataatgg
    58201 atatttaatg ccttgggcag accaaggagt gttactttta aatactgctc ttactgttag
    58261 agcgcatgaa gctaattctc ataagaacaa aggatgggaa attttcactg atagagtaat
    58321 atctatttta agtgagcgtg aagacccagt tatttttgta ctatggggaa gtaatgcacg
    58381 taaaaaagta gagttgattg atacaagtaa acattatatt ttggaagcac ctcatccaag
    58441 cccattgtca gcaagtaaag gcttttttgg atgtaaacac ttctctaaga taaatgaaat
    58501 tttgaaaaag ctaggaaaag aacctattaa ttggcagata gaaaatatat aaaagtaaaa
    58561 ggtaacaaaa tgataacaaa acaacaataa acaatgacat tgttgtaact aatagaaata
    58621 tgcttaaata gttgaaaata ctatgtatgc atatttctat ttttttgtca agttgacaac
    58681 tcttgaaaaa atagttacaa tttagttaca caaaaaacac aaataaaaaa agaaacttac
    58741 aaagcagaat tttatgaagc aaaatatata gtgtaaaaaa tcttagggag gaaattttat
    58801 atgaatttta aaaaattgag taatgctaaa gtctcggtaa tggcagttgt tttatcagtt
    58861 ggaatattat cgggatactc tgcgcttaat aaacaagtaa cattagtagt aaggggagaa
    58921 gaaagaacta tatcaacatt tagttctaat gtaggagacc ttttagaatc tcaaaacatt
    58981 agctatgatt caaatgatat agtaacttta gatgaaaata caaagttatc taatggagat
    59041 aaaatagaag taattgatgt aaaggaaaaa acagttgtag aaactaaaga cattccattt
    59101 gaagttacag ttgttgaaga tggctcttta ttaaagggtg attctaaggt taaagaagaa
    59161 ggaaagtctg gtaaaagtga attaatatat aaagaaactt atcacaatgg aaagaaagta
    59221 gaaaaggaat ttgtgaaaaa ggttgttaaa gctgagccag taaataaggt tgtaagcaaa
    59281 gggacaaagg tagaaatgca agtagcctca tcaaggggag aaagttcaag aagaatggct
    59341 tcatcatcat ctagtagcag tagtagtaac aatggtaaaa atatgagagt ggtagcaact
    59401 gcatatactg gtcacagtat aactgcaaca ggaacaaaac ctaagtgggg aacaatagct
    59461 gtagacccta aggttatacc atatggaact aaagtttata tacctcaatt tgacatggtg
    59521 tttactgcag aagactgtgg tggagcaata aaaggaaata aaattgatat ctacatgaat
    59581 gattcaaaaa cagtttataa ctggggaaga aaaactatag atatacgtat attaaaatag
    59641 ttaaataatt tatattttta ctggaaatta tattttgatt atatagagaa gaaactcttt
    59701 atagattcta aaaatataat ttccagtttt ttattttgga tatgtaataa aacaggtaaa
    59761 ttttaaccat gtatagataa aagctattta aattataatt tactatcata taaatctata
    59821 aaaattgttg caaagagtca aaatatatga tattatagat ttcgttgaga aggatttcat
    59881 tatgggagtg gatgggtgcc ggtgtgccct ctagtcttca aaactagtat gaggggttaa
    59941 gagcctctta ggtgggttcg attcccacgc attcccgcca atatgtaaaa ggtatctttt
    60001 aattaaaaga taccttttta aatttatttt aagataattt atttttaata atatataatg
    60061 ttttgtatta tataatgtaa attttctaat acaaaacatt atatatttag ataaaaatct
    60121 aggagtgtgg aaagatggaa aataatttta caacgagaac tagttttcta gttggagatg
    60181 atgggataaa aaaacttaat aattcaaata taatagtatt tggagttgga ggagttggta
    60241 gttttactgt tgaagcttta gcaagagctg gagtaggcaa tattactatt gtagattttg
    60301 atgatgtaga tataaccaat ataaatagac aaataccagc cctacattca actgtaggaa
    60361 gatacaaagt tgatgtcatg gaagaaagaa tattagatat aaatcctaat atcaatataa
    60421 aaaaaataag aagtctttat aataaagata ctagtgacga aatactaact gaaagatatg
    60481 attatgttgt ggatgcgata gacatggtaa gttccaaaat acatctaatt gaaacttgtg
    60541 aaaaaaaagg attgaaaata ataagttcta tgggtatggg aaataaatta gacccaacta
    60601 aaatagtcgt tacagatata cacaaaacaa gtacttgtcc tctagctaaa gttatgagga
    60661 aagaacttag ggatagaggt atcaaaaagt taaaagtagt atattctact gaacaaccaa
    60721 tagaacttaa gaagaaagta atgaatggta gaaaagtaac acctggtagt gtatcatttg
    60781 tcccatctgt aggaggttta ataatcgcat ctgtaatagt aaatgaacta ttaggacaat
    60841 aagttttaaa tattttaatt tataaatttt atatacaaat ttgaaggcta gaagcatgaa
    60901 tacaaagcaa ttttatattc atacttttag cctaattatt ttatattacc ttattttatg
    60961 tagttgtagt tttatttttt agattatgta tctatttcat aattatattt tgtaaatata
    61021 atttctccat cactataaaa aacaatatct cctattctat ctgttctata aattgataca
    61081 tggttttgtt ttagattatt aataacctcc ctatgtggat gaccatattg atttttatat
    61141 ccacatgata ttgcagctat atctggacta atttttttta taaattctaa agatgaagaa
    61201 gaattacttc catgatgacc tatttttata aaattaatat tatttaattt aaaagaatgt
    61261 aaaatttctt tttcattttc ttcttcagca tcacccataa ataaaaaaga attatcatta
    61321 aaagttaatt tgaaaactat agaatttaaa ttagattctt cttgtatata tgatggactt
    61381 aatacatata tatttatatt gttatctatg tttaaaacat
//
LOCUS       DAEPID010000014        61084 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.014, whole genome shotgun sequence.
ACCESSION   DAEPID010000014 DAEPID010000000
VERSION     DAEPID010000014.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 61084)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 61084)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..61084
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.014"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            212..541
                     /locus_tag="KR257_001002"
     CDS             212..541
                     /locus_tag="KR257_001002"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419063.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HBH0029721.1"
                     /translation="MQLNKEVLKGYIDILIVSILEKKDCYGYEIAKQVRERSEFELKE
                     GTMYLALKRMESKNLIKSYYSNEQSSGGRRKYYNLTNEGKDFLEIKKQEWRFIKKVMN
                     QFLGEVD"
     gene            545..1336
                     /locus_tag="KR257_001003"
     CDS             545..1336
                     /locus_tag="KR257_001003"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419065.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0029722.1"
                     /translation="MKLIDEYLDKLYKKCDNKSTIELKQEMRCHLIESANEFKLEGLD
                     EEEACKKAIERFDDGDEMQYELCNIIKELSLSLDRHKSIVMGFKKVLGYISIIAFLIS
                     GFMWYYNNSLQHNMYNLGKELDGEIKQLAERHDMTKIGEYKLELEKILDKDKYSKVKA
                     LRLYVIDMKDGNTNLSSSGLNANMVYEREADYNNISNFIQHLGYNGKDFLDKNGNIVN
                     PDIFLEYFFYFESEMLIPVAFAFGLLCIIAYFILRFKISLIKNNN"
     gene            1900..2982
                     /locus_tag="KR257_001004"
     CDS             1900..2982
                     /locus_tag="KR257_001004"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861129.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transglutaminase domain-containing protein"
                     /protein_id="HBH0029723.1"
                     /translation="MKKIRKLATKLLIAMMVLTSCMSVTVYGMTAKDVTAKTPKSYVA
                     GTNSIYGPKLSQAQLNSVAQATADFMNKKITKNMTTDAKIRVAYNHIKNNTTYVNWNA
                     AEGANTAYTLVTKKGACSGMCRSLKALCDAMGIECYYVHSTTNDHQWNLIRFEDGRLY
                     HVDIDANKSAGADIIYKSLTHPLPFDKKAYPAVGEVVKTQNPTPTVKKPTPAKPSAPV
                     GPGNHTMIADQQGAILDEVYGNNLRPKIEMYEGVPCSLINSSINTIKFTSKNSNLDPS
                     KHTVTVIGFMNTPYGMVALAPDGVPDEYPFEYDKPFSLDFTGKNLSAAELSKKCKENN
                     VIIKVEIGETASNSGRGMVAYARYVN"
     gene            complement(3194..4387)
                     /locus_tag="KR257_001005"
     CDS             complement(3194..4387)
                     /locus_tag="KR257_001005"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428474.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="FprA family A-type flavoprotein"
                     /protein_id="HBH0029724.1"
                     /translation="MSKVFEVKKDIYFTGVVDEGLKVFDIIMETEFGTTYNSYLIKDE
                     KTVLFDTVKANFKDEFLSNLSEVTDIAKIDYVVIHHTEPDHAGSLKYLLDINPNIEVY
                     CTKAAKLYLDGQINRPFNCHVIKDGEILNIGKRNLRFITAPFLHWVDTMFTYIEEDKT
                     LLTCDAFGCHFASVDAEVVNSEDYLKSAKHYYDCIVKPFAKHVLSAVDKVVGLNIEFD
                     TILTSHGPMLTKDPMAAVKRYVEWSTEAVNTTNQNQVSIFYLSAYSNTLEMAKKIKEG
                     LDKEGAKAELYDLEDMTLTEMHDTLVVSKVILLGSPTINKTMVKPMWDLFSVIDPMAN
                     QGKIAGVFGSFGWSGEGITMAETLLKSMSFKMPVESLKKKFFPSEETLKECMAFGAEF
                     AKLVK"
     gene            4706..6550
                     /locus_tag="KR257_001006"
     CDS             4706..6550
                     /locus_tag="KR257_001006"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428473.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TIGR03960 family B12-binding radical SAM
                     protein"
                     /protein_id="HBH0029725.1"
                     /translation="MNKVDLKKILKKVEKPARYLGNEINSIHKDTSNSELIRYAHCFP
                     DLYEVGMSHLGSHILYDVINKDEDVFCERVYSPAVDMENIMREKSIPLFALESREPIT
                     NFDFVTFTLQYELSYTNILNILDLANIPILKEERTLEDPFIMVGGPCAYNSEPLADFV
                     DVVILGEGEEVNLEVVNEYKEWKKNKTTREDFLYKISSIEGVYIPSFYDVKYNEDGTV
                     QSVTPNREGITKNPTKRIIKDVETVDYPEKLIVPYIDTVHDRIVLELFRGCTRGCRFC
                     QAGMIYRPIREKSVKRLKEILDKLVKNTGYDEISLSSLSTSDYSKLSELTDYLVDEYA
                     SNNIGISLPSLRLDNFSMEIADKIQQVRKSGLTFAPEAGTQRLRDVINKGVTEEDLEN
                     ATERAFEMGWNSVKLYFMIGLPTETYEDLDGIAKLAYKVIDIYRKVNGGKLKRSFSVT
                     VSTSTFVPKPFTPFQWHGQDTTEEVINKQRHLVNKLRNNNIKYNYHDSKTSLMEAVVA
                     RGDRRIGKVIYDAFRLGAKFDGWAEHFNLDIWKEAMEKNNLSIDFYAHRNRNYEEVFP
                     WDHIDVGISKKFLIREDENAKKEKITSDCRHNCNGCGINIHDIGRGLC"
     gene            6552..7253
                     /locus_tag="KR257_001007"
     CDS             6552..7253
                     /locus_tag="KR257_001007"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438070.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF2344 domain-containing protein"
                     /protein_id="HBH0029726.1"
                     /translation="MSKIIRVKFKKEGDMIYISHLDLQRLLQRAFRRAEINLSHSQGF
                     NPHPKMSYGNALALGTESQGEYVDIEIEEDDLSVEEFLNKVSIQLPDGIDFIKAKEID
                     RQTPSLSSVIDYGEYLFNIDLKRPMTKEFVKRKVIDFMNNKEIIITKKNKKGKMVEVD
                     IRPMIRTFDVLNLEDEHITLTATIATGSKTNLNTNILIPKILEMFELDIDPLDVDILR
                     RDLYVLEDGELVTPM"
     gene            7271..8692
                     /locus_tag="KR257_001008"
     CDS             7271..8692
                     /locus_tag="KR257_001008"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428469.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Rne/Rng family ribonuclease"
                     /protein_id="HBH0029727.1"
                     /translation="MKKIVIESLIGSQKTAVLEDERLTELFVEDNLNKKTVSNIYRGI
                     VKKVIPGIEACFVDIGFKKLAYLQLKKGSTIKSGQDILVQINKEEIGTKGAKLNTEIS
                     ISGRYIVYIPSNDRTTISNKITDEKERFRLKKITKAVNKENLGLIIRTEAQGCTHDEI
                     KKDIEELKLKYENILKEYKLGIGPKLLYKSLDFATKYVKDNVNDDIESIITNSYDKYS
                     ELKSILRGIDKTYVDKLCLEENRDVFDLYRIESKIEKLLNKKVWLKSGGYLIIEKTEA
                     LTVIDVNTGKFIGTGKLDETVYKTNLEAAKEIVRQLRIRDIAGIIIIDFIDMHKKKHQ
                     KEILHILEEEFNKDKRKAEVLGMTKLGLVEVARRREKESIDKYYLMSCPCCDGEQTIK
                     SVHYILDSIEKEIMRISEHTVYKNIMVEFNDFIFEQIKEYYMDIIDKIGEKYNIKISL
                     NANSTLKHNKTNVIFDKIVDNKM"
     gene            8793..9104
                     /gene="rplU"
                     /locus_tag="KR257_001009"
     CDS             8793..9104
                     /gene="rplU"
                     /locus_tag="KR257_001009"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012063435.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L21"
                     /protein_id="HBH0029728.1"
                     /translation="MYAIVKTGGKQYKVSEGDVLFVEKLEANAGDVVTLNEVLACSKD
                     GELKLGSPVVEGASVQAKVVEQGKAKKVIVFKYKAKKDYRRKQGHRQSYTKIVVEKIN
                     A"
     gene            9119..9436
                     /locus_tag="KR257_001010"
     CDS             9119..9436
                     /locus_tag="KR257_001010"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438074.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribosomal-processing cysteine protease Prp"
                     /protein_id="HBH0029729.1"
                     /translation="MIKVKYYYNDDFLLQGFCLKGHADFAEIGYDIVCAAVTSNAIAV
                     INSLDKLQKIEFEKVVGEEGHIECIVKDTHVKDAQLLLNHFQLAVKEIKREYPKNIKI
                     LKK"
     gene            9450..9740
                     /gene="rpmA"
                     /locus_tag="KR257_001011"
     CDS             9450..9740
                     /gene="rpmA"
                     /locus_tag="KR257_001011"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419086.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L27"
                     /protein_id="HBH0029730.1"
                     /translation="MLNMNLQLLASKKGVGSSKNGRDSISKRLGVKRFDGQLVTAGSI
                     IVRQRGTKIHPGTNVGKGSDDTLFALVDGTVKFERKDKKRKKVSIYPVAIAE"
     gene            9851..11128
                     /gene="obgE"
                     /locus_tag="KR257_001012"
     CDS             9851..11128
                     /gene="obgE"
                     /locus_tag="KR257_001012"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000469293.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GTPase ObgE"
                     /protein_id="HBH0029731.1"
                     /translation="MFIDKARIFVKAGNGGNGSVAFRREKYVPAGGPDGGDGGRGASI
                     IFEVDLGLRTLMDFKYQKKYQAQNGGDGSKGKRAGKNGENLVLKVPAGTVIRDEATGL
                     VLADLKKEGDTAIVAKGGIGGKGNQHFANAVRQAPAFAKSGTDGEERWITLELKMIAD
                     VGLLGFPNVGKSTFLSVVTKAKPKIANYHFTTLTPNLGVVQTKFGDSFVLADIPGIIE
                     GASEGIGLGHEFLRHVERTKVLIHIVDISGLEGRDPIEDFDKINDELKLYNEKLSKRP
                     QVVVANKFDILEDESKFEKFKSELEGRGYTVFKMSAATRQGIDEVIAYVSKMLKEVED
                     VELVSEEEMYRPELDIGTEEELSIDIEDGVYVVTGKALRRIMYSVNFDDMESLQYFQK
                     AMESQGVFDRLREMGIEDGDVVKIYELEFEFYN"
     gene            11180..11548
                     /locus_tag="KR257_001013"
     CDS             11180..11548
                     /locus_tag="KR257_001013"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428464.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YhbY family RNA-binding protein"
                     /protein_id="HBH0029732.1"
                     /translation="MLKGKQRAYLRSLANTLKPTTQIGKEGVTESFLEQLDGMLRTRE
                     LVKVTILENAGLDTKETANAVCEALRAEFVQAIGFKFTIYKRNIEEPKILFPGHEQAK
                     AKTKNNNVTKKGKPTKRAVR"
     regulatory      11640..11746
                     /regulatory_class="riboswitch"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00162"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="SAM riboswitch class I; Derived by automated
                     computational analysis using gene prediction method:
                     cmsearch."
                     /bound_moiety="S-adenosylmethionine"
                     /db_xref="RFAM:RF00162"
     gene            11849..13054
                     /locus_tag="KR257_001014"
     CDS             11849..13054
                     /locus_tag="KR257_001014"
                     /EC_number="1.1.1.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729519.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="homoserine dehydrogenase"
                     /protein_id="HBH0029733.1"
                     /translation="MKIAILGYGTVGSGLIDLIENNTSKRDIEVVGILVKNKEKHKYK
                     KYFDKITTDIEDIFDKDIDILVEVIGGLNPAFDYVTRALNKKIHVVTANKDLLAEKGS
                     DLIELANLNNVSIKFEASVAGGIPVLKPLIESLEGNNIKSINAILNGTCNFILSKMYD
                     ENLPYDVALKQAQELGFAEVNPDADVLGYDSARKLSILSTLSYGKIVYWKDLLLEGIT
                     SIDEKDIEYAKKLNCKIKLVARSKYESGEVSGFVRPALVDNNNMLSKIDNEFNVVILV
                     GDSVGELSFVGKGAGRGATGSAVYADIIDIIDNRSSNIKSFSKGKLDLSGLIEDECSA
                     VVRFGGYNNKDGILECLDKYVDSYDIIDDEELAIFVSAKSEHEIDRVLEIVKRNNYSE
                     SAKKLLKID"
     gene            complement(13255..13821)
                     /locus_tag="KR257_001015"
     CDS             complement(13255..13821)
                     /locus_tag="KR257_001015"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438082.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tyrosine-type recombinase/integrase"
                     /protein_id="HBH0029734.1"
                     /translation="MATRPIEIDEYKKIMELLHTGFTYSENGVEKRFRKNPKVALALM
                     LEANLGLRISDILRLKIGNFKGNMLEINEKKTGKLQYRPVNKNIIESINEHARKYNLK
                     SNDYLVNIKTKAIQKQLRIICKHLNLYNISTHSFRKLYATTQFEKSNNNLELVKELLN
                     HSSVATTQRYIRVTQQAINEASENFFIG"
     gene            complement(14101..15360)
                     /locus_tag="KR257_001016"
     CDS             complement(14101..15360)
                     /locus_tag="KR257_001016"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896088.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sporulation integral membrane protein YlbJ"
                     /protein_id="HBH0029735.1"
                     /translation="MKKNKIIAFFAPSIIVGVLVLGIILYPNEAIKSAREGFSIWSNV
                     LVPSLLPFIIGANLIVDLKIVDIIGFIINPITRFVFNVSGKSALAFAISTVSGYPVGV
                     SLASEFRSNGQISKYEAQRLVSFCSTSGPLFIIGSVGTGMFQNSNLGYLMILCHYLGT
                     ILVGLFFRNYGNENLPKTKLDLKTNIKNVINIRNSSGNGFFVLFGNAVFNGVNTLLTV
                     GGFVIVFSVVFKILSLFNVISLIASVIYLPLSFLGVSKELCQAFVSGLFEITIGCNKV
                     SSITSSPEILRASLASFLIGFSGLSILAQCCTFLSKTDIDLKLYILSKFAHGVLAAIF
                     IFILYPIANSAVLVSSFADTYNVIYNNLIWFYYLSYYDTILQIVVIIYLISAVFIAKK
                     HMKTLSTNGKLMRYKNTFFTKKFSRKK"
     gene            15485..16198
                     /locus_tag="KR257_001017"
     CDS             15485..16198
                     /locus_tag="KR257_001017"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896090.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="FadR family transcriptional regulator"
                     /protein_id="HBH0029736.1"
                     /translation="MFNSIASKKVYEQVIEQIQYKILNGELKKGDKLLSERELSEQMN
                     VSRTSIREAIRVLETMGVIESRQGEGNFICTNIEKTLIEPLSMIFKLNNGTLEDILEL
                     RIILEIEIAKLASKRITSSEVIELKHIIDEMRVETNKKDNNRVLVLLDQKFHSKLATL
                     SKNYLIQSLFMTASKLFDGFIEDAREKIIAEPFNENILLKQHEAIYNAVVENDVELAC
                     EKAKEHMDFISKNYRKNEN"
     gene            16316..17590
                     /gene="larA"
                     /locus_tag="KR257_001018"
     CDS             16316..17590
                     /gene="larA"
                     /locus_tag="KR257_001018"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438088.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nickel-dependent lactate racemase"
                     /protein_id="HBH0029737.1"
                     /translation="MVKLKVPYSKQGMILEIPDERFLGVLESKSDNYIEHKTQEEIVE
                     ESMNNPIGSNSLEELVKGKKNVVIITSDHTRPVPSRITMPIILRRIRNVNPEIDVKII
                     VATGFHRPSTREELIYKMGEEIVDNEDIVMHISTDDKSMCKVGILPSGGDLYINKLAY
                     EAELLIAEGFIEPHFFAGFSGGRKSVLPGIASAKTIMYNHCSDFIDSDNSRTGKLNNN
                     PIHEDMVYAAKVAKLAFILNVVIDKDKKIIASFAGDVEKAHTKGCRFVTELSKVNSIK
                     SDIVVTTNGGYPLDQNIYQSVKGMTAAEATCKDGGVIIMISACNDGHGGQSFYENVAN
                     ADSPKQLLDKIRSVDRVDTIPDQWEFQILARILSKYTVIMVTDKCNPEMIKKMHMKHA
                     FNFKEALEMANSIVGKESKVVVIPDGVSVIVK"
     gene            17607..18395
                     /locus_tag="KR257_001019"
     CDS             17607..18395
                     /locus_tag="KR257_001019"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003402402.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="electron transfer flavoprotein subunit beta/FixA
                     family protein"
                     /protein_id="HBH0029738.1"
                     /translation="MEILTCIKQVPGTTSVEVDETTGVLKRDGVDSKMNPYDLYALET
                     ALRIKEDKKANLKVLSMGPPQAKKVIEESFMMGADEGALISDRRFGGADVLATSYTIS
                     QGIKKMGKVDLIICGKQTTDGDTAQVGPEVAEFLDIPHVTNVTKLIEVKDESIVVEID
                     MPNDLQVCEIEYPCLITVEKDIFQPRLPSFKLKLNTKDREIPVYSLDDFEDKNENNYG
                     LNGSPTQVVRIFPPKPNTDKNIVRGNADELSFALVNKLEELKLV"
     gene            18409..19629
                     /locus_tag="KR257_001020"
     CDS             18409..19629
                     /locus_tag="KR257_001020"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428453.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="FAD-binding protein"
                     /protein_id="HBH0029739.1"
                     /translation="MSKIVVNQDKITDLKRILEICPFGAIEEKSGIVEISAGCKMCKL
                     CVKSGPKGAFEFIESSKVQINKDEWRGIAVYVEHHNGNIHPVTYELIGKAREMASKIK
                     QPVYCVFVGKDIKDKCSNLISYGVDEVFVYDEDEFKDFRIEPYSKAIENFIDKIKPTI
                     VLVGGTTLGRSLAPRLAARFRTGLTADCTILDIQSNTDLDQIRPAFGGNIMAHINTPN
                     NRPQFATVRYKIFSAPEKIENTTGKITLCKVEKKELKSKIKVLSVKEKNKEVGLEEAE
                     VIVVASRAIKKQEDMEMIYKLADKLNAQVAGTRPVIEAGWIDAKKQIGLSGRTVKPKL
                     IITCGVSGAVQFVAGMQGADYIVAINKDDKAPILDVAHLALIGDIYDIIPKLIEKIEN
                     NKDNNQKYMASAAK"
     gene            19640..21031
                     /locus_tag="KR257_001021"
     CDS             19640..21031
                     /locus_tag="KR257_001021"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729521.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="FAD-binding oxidoreductase"
                     /protein_id="HBH0029740.1"
                     /translation="MYKLIDKKDIDFLIDTCGEENVLVGSDINEDFSHDELGGIEKYP
                     EVLVNVLETEQVSKIMKYAYKNNIPVTPRGQGTGLVGAAVAINGGIMINLCKMNKILE
                     VDYENLTLTVEPGVLLMTIGQYVQDRDLFYPPDPGEKSATIAGNINTNAGGMRAVKYG
                     VTRDYVRGLEVVLPNGEIINVGGKVVKNSSGYSIKDLLVGSEGTLGIVTKAILKLLPL
                     PKKSISLLIPFPDLSMAIETVPKIIKSKSIPTAIEFMERDVILAAEEFLGKKFPDNTS
                     DAYLLLTFDGNSTEDIEKEYEKVANLCLENGALDVFISDTQERNDSIWSARGAFLEAI
                     KASTTQMDECDVVVPRDKIAEFIRYTHELQDKLKIRIKSFGHAGDGNLHIYILKDGMD
                     DNTWKIRLKETFDYMYKKSRELSGQVSGEHGIGYAKKEYLHESNSDAYMMLIKNIKLA
                     FDPKNILNPGKIY"
     gene            complement(21294..22574)
                     /locus_tag="KR257_001022"
     CDS             complement(21294..22574)
                     /locus_tag="KR257_001022"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896097.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nucleotidyltransferase"
                     /protein_id="HBH0029741.1"
                     /translation="MNILGLIVEYNPFHNGHIYHLSKSIEKTNATHTVAIMSGNFLQR
                     GEPALFDKYTRAKIAVENGVDLVIELPTLFACQSAEIFSHGAITILNSLNCINSICFG
                     SEEGNTEILYNIAEILANEPNEFKLLLKKYLDDGLLFPTARANALFDYIHQDKKNNFI
                     QNYSKEQLSKTLNSSNNILGIEYIKNLIHLNSSIKPFTISRVQSEYNSEEIESDICSA
                     TAIRTSLKENTDLFHLKNVIPEKTYNILNEKIDNGFLPMFDDFFFDILKTIILRDMDT
                     LKEYFEVNEGIENRIYKDIFTSEFLHELQLAIKSKRYTLTKIKRTLNNILLGIKKSDM
                     QLIKNIDTIPYIRILAFNDKGREILKEIKNKSEIKIINKFSNISFSLDDTIFKTLISY
                     DIKATNIYNSIYYKNNKDLVKGPMDFYTHPIYVK"
     gene            23037..24233
                     /locus_tag="KR257_001023"
     CDS             23037..24233
                     /locus_tag="KR257_001023"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419109.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="acetate kinase"
                     /protein_id="HBH0029742.1"
                     /translation="MKILVLNCGSSSLKYQLIDMNNEEVLCIGLVERIGIEGSILKHE
                     KAGRDDKYVVEQPMKDHKDAIALVLEAVAHPEFGAVKEMKEIDAVGHRVVHAGEKFAT
                     SVVITPEVEEALKECIDLAPLHNPANIMGIDACKAILPDVPMVGVFDTAFHQTMPKSS
                     YLYGLPHELYTKYGVRRYGFHGTSHNYVSQRAAEILGKDIKDLKIVTCHLGNGASIAA
                     VDGGKCVDTSMGFTPLEGLIMGTRCGDIDPAILPFLMRKEGLDADGLDKLMNKESGVY
                     GMTGISSDFRDIEDAAKNGDERAQATLEAYVKKVQKYIGAYAAEMNGLDVVVFTAGVG
                     ENGKAIRADIASNMEFLGMKLDKEANDVRGKETVISTADSKVKMLLIPTNEELMIARD
                     TLRLVK"
     gene            24326..24850
                     /locus_tag="KR257_001024"
     CDS             24326..24850
                     /locus_tag="KR257_001024"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419111.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF177 domain-containing protein"
                     /protein_id="HBH0029743.1"
                     /translation="MKVSIEKINRKETDKIDLNFCEKIDTISYCDEIYKLVSPVNLKG
                     KVSKTNKGLYLDIDVNFTIVDNCSRCLKEVEIPLEYSIQGFLVKEEDYDEDEFEEFDP
                     FIFDGEEIDLIDIIEQTLDFNVPHKVLCSENCKGLCQVCGANLNEEECSCSEITNDEE
                     YIDPRFAKLKDLFN"
     gene            24875..25051
                     /gene="rpmF"
                     /locus_tag="KR257_001025"
     CDS             24875..25051
                     /gene="rpmF"
                     /locus_tag="KR257_001025"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419113.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L32"
                     /protein_id="HBH0029744.1"
                     /translation="MAVPKRKTSKSNTKMRRAANSKMEATGFVSCPQCHEPKLPHRVC
                     PDCGYYKGKEVVSK"
     gene            25258..25815
                     /gene="fapR"
                     /locus_tag="KR257_001026"
     CDS             25258..25815
                     /gene="fapR"
                     /locus_tag="KR257_001026"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419115.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcription factor FapR"
                     /protein_id="HBH0029745.1"
                     /translation="MKKKSKAQRQKELIDMLKTDPFYTDEELSSLFDVSIQTIRLDRM
                     SLNIPELRERVKSIAETQSSKVKTLGVKEITGEIIDLSVGRLGISMLEVTQDMIYSKT
                     NTLKDTYIFSLADSLAMAIIDAPKVIMRVANVKSFKLIEQQDRLIAKAEVYRNIDKKH
                     YVKVVINNKAQEQIFRGKFIFEELD"
     gene            25826..26848
                     /gene="plsX"
                     /locus_tag="KR257_001027"
     CDS             25826..26848
                     /gene="plsX"
                     /locus_tag="KR257_001027"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419116.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphate acyltransferase PlsX"
                     /protein_id="HBH0029746.1"
                     /translation="MKIVIDGMGGDNAPKSNVEGAVNAIKEYQVDLIITGDKDLLEKE
                     FSNYEFDRNKLEIVHTTEIIENEDKPVKAIRSKKDSSMVVALNLVKEGKADAIISAGN
                     TGALLAGGLFVVGRIKGIDRPCLCSAIPNVKRGMTLIADCGANADCKPKNLVEFAAMS
                     NIYSRKVLGLENPKVALANVGLEEGKGNDLVKRSYEEIKKLDLNFIGNVEAREVINAY
                     TDIIICDGFTGNILLKSAEGVALSVMSLIKETFMASTKSKIGALLIKDDLRKLKSFID
                     YSEYGGAPLLGLNGGVIKAHGSSDAKAIKNAINQGIKFSKGKVVEDINQFISKYNEEN
                     KNNEDE"
     gene            26874..27860
                     /locus_tag="KR257_001028"
     CDS             26874..27860
                     /locus_tag="KR257_001028"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438099.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ketoacyl-ACP synthase III"
                     /protein_id="HBH0029747.1"
                     /translation="MNTKAGILGVGSYLPEQSYDNFHFEKIMDTSDEWISTRTGIKER
                     RFAKESEATSDLASKAALKAIECAKLNVEDIELIILATITPDMSLPSTACIVQDAIGA
                     VNATAFDISAACSGFVYGVTIAKQFVETGCYKNVLVIGAETCSKFLNYDDRTTAVLFG
                     DGAGAAVIGPVNEGGILSTHMGSDGKGKDCLKVPAGGSRLKASKETVEANLHTIEMAG
                     SDVFKFAVRKMAETSLRALEKANLNTTDIDYLVPHQANIRIIQASSKRLELDMKKVYV
                     NIDKYGNMSAASIPVALDEAYREGKIKKGDNVVLVGFGGGLTWGASVVKWTL"
     gene            27969..28898
                     /gene="fabK"
                     /locus_tag="KR257_001029"
     CDS             27969..28898
                     /gene="fabK"
                     /locus_tag="KR257_001029"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419125.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="enoyl-[acyl-carrier-protein] reductase FabK"
                     /protein_id="HBH0029748.1"
                     /translation="MNKICKILNIKYPVIQGGMAWVATASLASAVSNAGGLGIIAAGN
                     APKEAIKKEIVECKKLTDKPFGVNVMLMSPFVDDIIDLIIEEKVQVITTGAGNPAKYM
                     DRLKEAGTKVIPVVPTIALAQRMEKLGATAVIAEGTEGGGHIGELTTMVLVPQVADAV
                     NIPVIAAGGIVDGRGIAASFALGASAVQVGTRFICSEECSVHSNYKNLVLKAKDRDAI
                     VTGRSTGHPVRTLKNKLSKEFLKMEQNGATPEELDKKGTGALRFATVDGDIEKGSFMA
                     GQSAAMVKEITPCKEIIEAMVNQAREIMPAIEL"
     gene            28914..29864
                     /gene="fabD"
                     /locus_tag="KR257_001030"
     CDS             28914..29864
                     /gene="fabD"
                     /locus_tag="KR257_001030"
                     /EC_number="2.3.1.39"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902293.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ACP S-malonyltransferase"
                     /protein_id="HBH0029749.1"
                     /translation="MGKVALVFPGQGAQYVGMAKDLYENNTVAKSVIDEASDALNMDL
                     KNLMFNGNEEELSKTENTQPAMVTHSVAVLKAVQAQVDLKYSACLGLSLGEYSALVAA
                     DAIDFKDAVCLVKKRGKFMQDTVPTGVGAMAAILGLDRSILENVVKDIQGGIVEVANY
                     NSPGQIVISGENEKIEEAMVKCKEAGAKRAVKLNVSGPFHSSMLREAGVKLASELEKV
                     NITKPKVDVVANVNADYYKNEGKDLLIKQVSSSVLWEDSIERLLNDGYDTFIEMGPGK
                     TLKAFIKKIASNKKANVNIYNIDGIDSLNEFVQNYRNGEI"
     gene            29864..30613
                     /gene="fabG"
                     /locus_tag="KR257_001031"
     CDS             29864..30613
                     /gene="fabG"
                     /locus_tag="KR257_001031"
                     /EC_number="1.1.1.100"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888925.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="3-oxoacyl-[acyl-carrier-protein] reductase"
                     /protein_id="HBH0029750.1"
                     /translation="MINLTGQVAVVTGGSRGIGKEIAKKLASFGADVVINYTSKEDEA
                     LKTKNEIESMGVKCTSIKCDVSKFDEVNQMIDSVVSEFGKIDILVNNAGITKDGLLMR
                     MKEEDFDRVIDINLKGVFNCTKAVTKPMMKKKYGRIINMTSVVGIMGNAGQTNYCASK
                     AGVIGFTKASARELASRNININAVAPGFIETDMTKVLSDDVKESTLANIPKKSYGKPE
                     DVANAVAFLVSDMSSYITGQVINVDGGMVMQ"
     gene            30667..30891
                     /gene="acpP"
                     /locus_tag="KR257_001032"
     CDS             30667..30891
                     /gene="acpP"
                     /locus_tag="KR257_001032"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419132.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="acyl carrier protein"
                     /protein_id="HBH0029751.1"
                     /translation="MFNKVVEIIIEQLGVEDKEITMETSLMKDLEADSLDAVEIIMAL
                     EDEFGIEIPDTEAENFKSIGDIVKYIEANK"
     gene            30920..32158
                     /gene="fabF"
                     /locus_tag="KR257_001033"
     CDS             30920..32158
                     /gene="fabF"
                     /locus_tag="KR257_001033"
                     /EC_number="2.3.1.179"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438103.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="beta-ketoacyl-ACP synthase II"
                     /protein_id="HBH0029752.1"
                     /translation="MNKRVVITGLGCVTPLGTGKEEFWSNIKSGVSGIDKITNFDAST
                     YQTQIAGEVKNFHPEEYISKKELKRLDKFAQFAIVSAKLAVEDANLDLDKVDRERFGV
                     IIGSGIGGVEAIETQHKILLEKGNKRVSSLFVPMMIGNMAAGQVSIFLGAKGPNTNVC
                     TACASGTHSIGDAFKVIQRGDADIMVAGGSEAAVTGLAFAGFCNMKAMSTRNDDPKTA
                     SRPFDKDRDGFVMGEGAGIVILEDLEHALARGAKIYAEVVGYGLTADAYHMTTPAENG
                     EGAARSMNMALKDGNVPLEEVDYINAHGTSTYYNDLYETMAIKTVFGEKAYDLCVSST
                     KSMTGHLLGASGAIEAVVCAMSIEDSFVPPTINIQEVGEDLDLDYVPNQGKEKNIRYA
                     LSNSLGFGGHNATIVLKKYV"
     gene            32384..34102
                     /locus_tag="KR257_001034"
     CDS             32384..34102
                     /locus_tag="KR257_001034"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892922.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GGDEF domain-containing protein"
                     /protein_id="HBH0029753.1"
                     /translation="MNFRLPKKRLPKKIIFICIILISIILFIKHDQNGLKEREIINKG
                     KYMSESLVADKEYDEAKKVVKTSFESIPEKKYNKVYNEVWDMLKTISYVPDGTKIVID
                     SLEKMRESDVKLSDECRFNIEKRLASVYIMDNNYSKAVDLTVKSIKLAEKLGNNYEKA
                     RLDVDLASIFLKIGGYETGEKLIKDSFKIDIDEGEKNGMVRLYAIINLAEIYVEEGEY
                     DKAIEISSRIKDYKKFVNTDNYNDFDIMASIMQSNAYVGKNNIQKAKTFLEKADYLIK
                     SDRTVYILDKDMYYYMAMGNLEYKSENYNSAIDNYKKSLEISTKRKLTQEKIKNLNKI
                     LNIYEKQGNIESLNEYQKMLINEYKENKSIRDSETSFYIIDKVSNESKLFEKTKKEIK
                     YYKILFTVILIAILGSTFLYNRLKYFKAQNLHDGLTNVYNRKSFDIMYEKYREKDDNF
                     ALVMIDIDNFKLINDNYGHKFGDTVIKGITNTICVMLEQDDKVFRYGGEEFSVLIRNK
                     SGDEVADIIDSIRVAIANKKWNDDVTVTISAGVAHVSDSKDVLEEADKNLYKAKQLGR
                     NKVVYK"
     gene            34133..36133
                     /locus_tag="KR257_001035"
     CDS             34133..36133
                     /locus_tag="KR257_001035"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018112784.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sigma 54-interacting transcriptional regulator"
                     /protein_id="HBH0029754.1"
                     /translation="MKQSIAIVTDKITKLSSFLEENIRLVLGNYIDINHYYLEVLKEN
                     DKIQGDFVLVMNDDRLNSMRKHLVQDSKIIVIRRTLKENEIYGLFSIPNGTEVLVVND
                     TKETTLETISLFYKIGVKNLKFTPYIEGKIYKNIDIAITPGVKGKVPSYINKVIDLGN
                     RYIDISTFIEIINGLRIDVKEIRKNLMAYSESLISLDNGVKDNYRQLFLKIEEQDVIL
                     NLSKDGIIFTSADGIINTFNKEALKILGINENPQGKNIEDIISEDLNILLEDKEIIDE
                     VVFTNKKYINVNKKSIFSMGNKAGIYYNLQEITYIKKLEQNLTNKLREQGQIARYTFK
                     DIKTKNKNMVKCVELAKKISKSELSVLIIGESGTGKELLSQSIHNASNRSNQPFIAVN
                     CAAVPDSLLESQLFGYEKGSFTGALREGKKGLFELANNGTIFLDEIGDMPPLLQTKLL
                     RVLQEKQVMPIGSHNVINIDVRVIAATNKNLLKMIREGKFREDLYYRLNVLPIDVPSL
                     RNRKEDIITLMNFFLKNNIRLSPEVITILEKYNWPGNIRELQNVASYVSLMCDSMVFR
                     DDLPPYIRVECANNYEDGFGYTRKEFEEILRILYERRESSSGIGRGFIIEKLIQEGIE
                     ISESKVRKVLSYLSECGYISSKSGRGGSQITSEGIKLYNNIN"
     gene            36484..36729
                     /locus_tag="KR257_001036"
     CDS             36484..36729
                     /locus_tag="KR257_001036"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419141.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TIGR03905 family TSCPD domain-containing
                     protein"
                     /protein_id="HBH0029755.1"
                     /translation="MKYKTTGTCATEIEFEVKENKVTNVNFIGGCDGNLKGLKVLVEG
                     MNIEDVIQKLKGIECKTKPTSCPDQLSLALENYMNIK"
     gene            36764..37489
                     /locus_tag="KR257_001037"
     CDS             36764..37489
                     /locus_tag="KR257_001037"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438111.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="gamma-glutamyl-gamma-aminobutyrate hydrolase
                     family protein"
                     /protein_id="HBH0029756.1"
                     /translation="MKPIIGILGNLIIMENGMFPGLERSYVNNDYINAVLKGGGSPVI
                     IPVNTDKEVIKKQIEMVDGVLISGGWDINPQLYGEETREETTFIYPEVDEFDLIAISI
                     ALELKKPILGVCRGLQILNVSLGGTLYQDNNLIEGSYIKHTQSSKRHVATHKVDVKEG
                     SILEGILGKQLLTNSYHHQSVNQLGKGLKAIAYSKDGIIEAIEKEDENFVVGVQWHPE
                     MMVDYCDKMEKLFKYFINICSNL"
     gene            37511..38824
                     /locus_tag="KR257_001038"
     CDS             37511..38824
                     /locus_tag="KR257_001038"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419145.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amino acid permease"
                     /protein_id="HBH0029757.1"
                     /translation="MNEKNKMGLISIILLGINAVVGAGVFLLPGDAMKSFGVASIFVY
                     IFDMLLVLSMAFCFAEVAGKFNKNGAAYVYTKEAFGDFCGFEVGLMKWVIGCISWGAL
                     IVGFPTSLSAVWAPAGEPHIQKIIIVVMIVGLTIINLLGVSLSKIVQNVITVGKLIPL
                     ILFIGIGIFFIKGVNFTSSTMVPPGAGATEFGAAALLMFYSFTGFESIAVAAEDMENP
                     QKNIPIAIISVIVIASIIYILNQVVCVGILGDSLSSTSTPVADAARICFGNMGAGLVT
                     FGTLVSVGGICMCGAFVNPRSCVALADDKMLPRIFARKDKKGTPYVAIIATMLITIPI
                     ALSGSFAELAAISAVARFIQYIPTSLSVLVFRKKRPELVGTFKTPFGAVIPLIAVCVG
                     TWLLFQASMHQLIMGLGALAIGVPLYFIMKSYNRKVYDENLKKIV"
     gene            39030..39569
                     /locus_tag="KR257_001039"
     CDS             39030..39569
                     /locus_tag="KR257_001039"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009905353.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HBH0029758.1"
                     /translation="MPTITLKNGVDVLIREGVREDAQSIIDFYNEVGGETHFLSFGKD
                     EYKISLEEQENAIESAKASDNSVKLIAFIDGEIVGIATIDSNQKAKGKHVGVLGIVVK
                     EKYWGIGLGKRLMLDLIEWCKSNGITKKITLVTNEENYNAIGLYKKVGFEVESILKKE
                     CYYNGVYTDLIGMSLLLGI"
     gene            39658..41643
                     /locus_tag="KR257_001040"
     CDS             39658..41643
                     /locus_tag="KR257_001040"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428429.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="fructose-1,6-bisphosphatase"
                     /protein_id="HBH0029759.1"
                     /translation="MKNLCKISDDYLNSKLKYLKLLSKQYPSISKASTEIINLEAILN
                     LPKGTEHFITDVHGEYEPFVHVLKNGSGVIKRKIEELFSNTIRDSEKKMLATLVYYPE
                     QKLDLIIKQEENIDDFYRINIYRLIELCKYASSKYTRSKVRKLLPENFKYIIEELLHE
                     HVKSEHKEEYYKSIVETIVDIGIAKEFIIAISTVIQKLVVDRLHVIGDIYDRGPRPDI
                     IVDKLIEHHCVDIQWGNHDILWMGAASGEKTCIANALRISARYANLDIVEDIYGINLL
                     PLATFAIEMYKDDPCKEFIPKVNDQSVTTTEKSLMAKMHKAISIIQFKLEGEVIRRRP
                     EFEMEHRLLLNMINYDEGTINLKGKTYKLKDTYLPTIDKKDPYKLTMEERNVIDKLVS
                     SFRGSEKLQKHVSFLFSKGSIYLKANSNLLIHGCVPLNEDGSFMSMNIMGKEYKGKAL
                     MDKMESLAREGFFFKDKAEEKLYGMDIMWYLWTGKCSSLFGKDDMTTFERYFIAEKET
                     HKENKNPYFKLRENEMACKRLFEEFDLELDESHIINGHVPVESKNGESPIKANGKILV
                     IDGGFSRAYQKTTGIAGYTLIYNSRTLQLVSHEPFNSAEEAIANESDILSTTVVVEHK
                     AKRKMVRDTDEGVKIQEEIEDLKLLLMAYKKGLIKEM"
     gene            41867..42835
                     /gene="spoIIIAA"
                     /locus_tag="KR257_001041"
     CDS             41867..42835
                     /gene="spoIIIAA"
                     /locus_tag="KR257_001041"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896114.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="stage III sporulation protein AA"
                     /protein_id="HBH0029760.1"
                     /translation="MNKLSDEIINSLSTTIREKVEKVSNNNLNIEEIRLRSQKPLILN
                     ANSKDYFYNQKTMTLDLNQQNSYVVTREDVEQTFQIICKYSIHSFMDDIKKGFITLRG
                     GHRVGLVGKAIVEDGQVKNIKHISSLNIRVSREIIGCSDKILSHIIKGKNQINNTLII
                     SPPQCGKTTLIRDIVRNLSNGNEDYGFKGLKVALVDERNEIAGAYLGVPQMDVGIRTD
                     IIETCPKDLGITMLLRSMSPNVIVTDEIGSEKEIKALYTALNGGIGLITTVHGDSIED
                     IQNRKELNRLLDKELFKKVIILSAKRGAGTIEKIYDLEEKRWYFAN"
     gene            42825..43346
                     /locus_tag="KR257_001042"
     CDS             42825..43346
                     /locus_tag="KR257_001042"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419153.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="stage III sporulation protein AB"
                     /protein_id="HBH0029761.1"
                     /translation="MQIKIIIIAFLIGSSYLIGEQIYKTYTRRHKQLNDLIRVLEILR
                     MDLSFGLYTLEEIFNRIGGNKEFCFWKFFYQISEGLHNEQSKTLEIIISENIDVLSKE
                     TYLGNKEIEELKNLILTLGKSDIESQQRMIDLSIENLKKQTYETKEDINKKGVLYKKL
                     VTFIGIGICIILI"
     gene            43363..43560
                     /gene="spoIIIAC"
                     /locus_tag="KR257_001043"
     CDS             43363..43560
                     /gene="spoIIIAC"
                     /locus_tag="KR257_001043"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018589775.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="stage III sporulation protein AC"
                     /protein_id="HBH0029762.1"
                     /translation="MEISLILKVAGVGILISVLNMILEKTDRKDWAGLTTLAGVIIVL
                     GMVITEISDLFNTVRTMFQLY"
     gene            43576..43962
                     /gene="spoIIIAD"
                     /locus_tag="KR257_001044"
     CDS             43576..43962
                     /gene="spoIIIAD"
                     /locus_tag="KR257_001044"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419158.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="stage III sporulation protein AD"
                     /protein_id="HBH0029763.1"
                     /translation="MEIMQLIGIAIISTTLCLVIKKDRPEIANFIAIITGVIILLSVM
                     FKLNFIVDSIQDLANKANIPTMYISLIIKLIGIAYLMEFAIQLCKDCGEGNIASKLEF
                     GGKIIVMSMSFPILLSIVEMVVNIIP"
     gene            44047..45252
                     /gene="spoIIIAE"
                     /locus_tag="KR257_001045"
     CDS             44047..45252
                     /gene="spoIIIAE"
                     /locus_tag="KR257_001045"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428423.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="stage III sporulation protein AE"
                     /protein_id="HBH0029764.1"
                     /translation="MKKRFLPMIIGFLFTFFFVNIFAIMIFANEVPSSEDKEYGETKN
                     SIDKYIDGQLDKLDINEIQDYINKEIVINDVNLKSFVKDLISGEKNILDLFNKDGLKI
                     LMFDEFKASLKVVAVILVLALLSSILKSLENSFSSGAVSQIATYIIFITMVSLTLIGF
                     KDVLQICYDAIDHTVGLMQVIMPILITFLLLIGFPITSTTLNPIFIGGVTFINVFFKN
                     FLFVSITVAFGILIINNLSKNIRLKRFFSFVKQINYVSIGAMFTVYLGLVSIQGLYVT
                     SFDKFSVKTAKFAIGNFIPVVGGFVSDSVDILLSSSQLIKNIFGGIGLILLVGICLLP
                     VIKILSVIVVYKLAAIIVEPVGEDGISNFLNEVANLMIIMLASVIAITVMFFVTVAIL
                     TSISVVSQG"
     gene            45312..45929
                     /locus_tag="KR257_001046"
     CDS             45312..45929
                     /locus_tag="KR257_001046"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428421.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="stage III sporulation protein AF"
                     /protein_id="HBH0029765.1"
                     /translation="MLEGIKAWIVSVLIGAFIVNIVDMILPSSKIKPYVNLVLNFMFV
                     FIVITPVVGFFSKDMSLEDRILKSMGNYNKQYVDSTNALAKETGNNSLSKGYEDGLKE
                     VLKLKLDEYGYDLEDIELNGANINNIKIKEKNNSAKSNNSSNEENKNNSTKREEENIN
                     SNDKENSKQVFKKGTEYGLNLNEEKLKNDLIKVLDVSIEDIQIDK"
     gene            45941..46495
                     /locus_tag="KR257_001047"
     CDS             45941..46495
                     /locus_tag="KR257_001047"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419164.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="stage III sporulation protein AG"
                     /protein_id="HBH0029766.1"
                     /translation="MLKNLNDKDKRKVYSLITIAGICVVSLVLLSCFPSSKSDKQVGK
                     TETNKNAEKQVTKEQEKDDLESKLTAILSKIDGAGDVDVMVTFESSEEIQPAFNSNNT
                     TETTEEKDAQGGERTVTTSSENKTMITSNSSDPVVIKTTEPKIKGVIVVASGASDPSV
                     KETLYSAVQTSLQVAGHQVEIYSK"
     gene            46522..47211
                     /locus_tag="KR257_001048"
     CDS             46522..47211
                     /locus_tag="KR257_001048"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888947.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SpoIIIAH-like family protein"
                     /protein_id="HBH0029767.1"
                     /translation="MKFNYKGRGFVIITLTAMLVVVGTVNYQLSKKSLLETSKEFKAY
                     EEAQLQKNTDDSYSSKTEDSSNVDKQGGKESADIDIVDSKASKVKEKATETSKEIKAQ
                     LSSEKNMKKASYILDMKMNREKQRNELVQDLNEMINNPSTTEESRKEASNMKLNIVKI
                     QEKELQIENLLSTKGYEEALVYISDNKVNVVVNEAKLEKKDAAKIFDLVAEQANVKYE
                     NIKLTNNNSNK"
     gene            47321..47683
                     /locus_tag="KR257_001049"
     CDS             47321..47683
                     /locus_tag="KR257_001049"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419170.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Asp23/Gls24 family envelope stress response
                     protein"
                     /protein_id="HBH0029768.1"
                     /translation="MEDNKFGQVKISNDVIATIAGLAALEVEGIETTATLTDKLLKNN
                     GVKIQIEEEDVNLDVMVTIKYGMSIPDTAFKVQENVKNTVETMTGLKVSQVNIHIQGI
                     SFKKDKVDKEEAKATKKN"
     gene            47768..48274
                     /gene="nusB"
                     /locus_tag="KR257_001050"
     CDS             47768..48274
                     /gene="nusB"
                     /locus_tag="KR257_001050"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428415.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcription antitermination factor NusB"
                     /protein_id="HBH0029769.1"
                     /translation="MKKDRAQKSTTREYIMKLIYQININKEDFETLEDKVDNFLKDNS
                     EHIINRYKELALQYSKNTNLKLEDTEIEDVIDKKYINTVCKALKENHDKIDELINKHA
                     KNWTVDRMPKVDVSILRLSVCEILYLDTPNKVSINEAVELAKIYCDDKSPKFINGILG
                     SVVDEIGK"
     gene            48258..49328
                     /locus_tag="KR257_001051"
     CDS             48258..49328
                     /locus_tag="KR257_001051"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018112785.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="O-sialoglycoprotein endopeptidase"
                     /protein_id="HBH0029770.1"
                     /translation="MKLGNNIIIGIDTSCYTTSIAAISLDKKVIFNEKIMLEVRDNSK
                     GLRQSEAVFQHINNLGILSDRIKSFKDKFNVEGVCSSKKPRPVENSYMPVFNVGHNFG
                     KLLSSIYGCRFYETTHQENHIEASLLNSKLKNNNKFISVHMSGGTTEILLTSKQDSHH
                     NVCDTNLGKIAKISIKKDDKSKLYNNFGYNIDIIGGSKDISFGQLIDRVGIKLGYKFP
                     SGKYLDENALNCNLKIESGLKTSVRDGYMNLSGLENQVNKIINDNGDNTNQKEYISKL
                     VLDSVVRNMFKSLVYLCETYNVNEVVFAGGVSASKYILRELSMKLRKKHIEAYFTEPQ
                     YSTDNAVGCAIIGLNNFLGERV"
     gene            49325..50530
                     /locus_tag="KR257_001052"
     CDS             49325..50530
                     /locus_tag="KR257_001052"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902301.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="exodeoxyribonuclease VII large subunit"
                     /protein_id="HBH0029771.1"
                     /translation="MKLRALDISEANSYIKRILINDPILSNLKVKGEISNFKVHSSGN
                     VYLSLKDETSKLNCVIFKSNFNRNLKLDNGVKIIANGYISVYERDGAYQLYINEIEIE
                     GIGNLHIEFNRLKEKLNKEGLFDPKYKIPIPKMPNSIGVITSPTGAVIRDIINVIKRR
                     YPKVNIKLYPVTVQGDKSAEEICEAIRFFNHMKNVDTLIVGRGGGSIEELWSFNDEMV
                     AREVFNSQIPIISAVGHETDFTICDFVSDMRAPTPSAAAEIATPSLDDINYKLGNIKS
                     RMSKSLTNQIELDQYRLETVFNKINNYLDSYTIKDKVIQLDKIYDKIIFGIENNLKLE
                     DEKLVKIGALLHNLSPLATMDRGYSITQKNGKVINSIKGLKIKDSIDIVLKDGNLECM
                     IDKIENKEG"
     gene            50532..50747
                     /gene="xseB"
                     /locus_tag="KR257_001053"
     CDS             50532..50747
                     /gene="xseB"
                     /locus_tag="KR257_001053"
                     /EC_number="3.1.11.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419178.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="exodeoxyribonuclease VII small subunit"
                     /protein_id="HBH0029772.1"
                     /translation="MNLTYEEAYKRLESILSELESKNASLDESLSLYEEGISLYKHCN
                     KLLDDAKLKISKFNQLGIEEDFKIEEE"
     gene            50750..51637
                     /locus_tag="KR257_001054"
     CDS             50750..51637
                     /locus_tag="KR257_001054"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428409.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="polyprenyl synthetase family protein"
                     /protein_id="HBH0029773.1"
                     /translation="MEFKQCLKEKASFVEKVLKEYMPKEEGYQKTVIEAMNYSLSAGG
                     KRLRPILTLEACKIVGGNEDEAIPFAIAIEMIHTYSLIHDDLPALDNDDLRRGRPTNH
                     KVYGEAMGILAGDALLNYAFEVMLAGSINKENPEKYLKAINEIAKGAGIYGMIGGQVV
                     DVESENKQIEKEKLDYIHMNKTAAMMVGCMRAGATIGGANSEQMEEITKYAKNIGLSF
                     QIVDDILDIVGDEAKLGKKVGSDIENHKSTYPSLLGLDKSKEIAHNLIDEAKKSIEKL
                     SDDVDFLKGLAEYIIDREY"
     gene            51667..52104
                     /locus_tag="KR257_001055"
     CDS             51667..52104
                     /locus_tag="KR257_001055"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428407.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="divergent PAP2 family protein"
                     /protein_id="HBH0029774.1"
                     /translation="MDFFSEIFNNGALGISLIACFLAQFIKIFTGKEKRIELSRILIS
                     GGMPSSHSSFVTSLATVVGIEKGFNSTDFAIITVLALIIMYDAAGVRRAVGKQATILN
                     QMVADIQHGKHIEQKKLKELIGHTPLEVWFGALLGIVTALILM"
     gene            52138..54003
                     /locus_tag="KR257_001056"
     CDS             52138..54003
                     /locus_tag="KR257_001056"
                     /EC_number="2.2.1.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438134.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="1-deoxy-D-xylulose-5-phosphate synthase"
                     /protein_id="HBH0029775.1"
                     /translation="MYKYLDKVNSPKDIKNMSIEEMDLLAKDIRKFLVKSVSKTGGHL
                     ASNLGVVELTLALHKVFDSPKDKIVWDVGHQSYVHKIVTGRKDCFVSLRQFNGLSGFP
                     KENESPHDIFDTGHSSTSISIATGIACARDIKKENYSVISVIGDGSITGGMALEALNQ
                     LGYIDTNMIVILNDNEMSIDKNVGGMSKYLSSIIRNSTVEKMTDEVDKILNVTQTGEI
                     LSKTAHRFKDKLMYSFSPQDCSFFDSLGIRYYGPIDGHNTKELIDILRKAKHKKGPVL
                     LHVITKKGKGYRFAEEQPDKYHGVSKFDIKTGVTSAKVKSMSISVGEKLVDMANSNEN
                     IVAITAAMPSGTGLNLFESAYPKRYYDVGIAEQHATGFAAGLAKNGMKPYFAVYSSFL
                     QRAYDQVIHDVCITKKPVTFLIDRAGLVGNDGETHHGMFDLSYLNSIPNIVVMAPKDT
                     REMELMMDLSLKLDCPLAIRYPRGSSYYLDKGEYGEIVLGKYEVLDDGQDTVILCIGS
                     MVKHALEAKEILSREGINPTIVNARFLKPIDEGMLKALLKNHKNVVTIEDNIVTGGFG
                     SRINKFIIDNEYNVNILNIAIPEEFVKHGNIDELYDFVGLSPKSIADKIRKLVIE"
     gene            54136..54948
                     /locus_tag="KR257_001057"
     CDS             54136..54948
                     /locus_tag="KR257_001057"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428401.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TlyA family rRNA
                     (cytidine-2'-O)-methyltransferase"
                     /protein_id="HBH0029776.1"
                     /translation="MKKRIDLLLVEQGYFESRERAKKAIMAGLVFVDNQRCDKAGTEV
                     KEDCSIEVKGNPIPYVSRGGLKLEKAMKNFDLTIDGKVCMDIGASTGGFTDCMLKNGA
                     IKVFSIDVGYGQLAWKLRQDDRVVCMERTNIRNVTIEDTKQFADFASIDVSFISLKLV
                     LPKAKELVRHDGEVVALIKPQFEAGREKVGKKGVVREKSTHIEVIKMISDFSVENGFE
                     ILGLDFSPIKGPEGNIEYLIHLRNGNEGYEFDGETYNNKIVEVVEASHNLDK"
     gene            54968..56647
                     /gene="recN"
                     /locus_tag="KR257_001058"
     CDS             54968..56647
                     /gene="recN"
                     /locus_tag="KR257_001058"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888953.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA repair protein RecN"
                     /protein_id="HBH0029777.1"
                     /translation="MILELYMKNCALVEELRLNIDKNLNILTGETGSGKSIIIDALGL
                     CLGDKYDRSFLRKGTDKGLVEAVFFSDNRYLKKILEENDISMEDDNLLVITRLIYSDG
                     KSTARVNGRTVKVSLLKEIASTLIDIHGQHQNQALFNKDTHLKFLDLFGENELEEFKI
                     AYKNVYHKYSEVKKALNCLTENKDEMQIQREIDLLRFQINEIEAANLNKNEYEDLLKQ
                     REVYRNSEKIYNNLNSSYSKLHNGEYNVIDLIGLASKELNDISKYDSVLSEYSDTVER
                     IMYELQDISGEIRNYKDNIDFEPYELEQIELRIDEINNLRRKYGDSIDDIFEYYGKIK
                     DRLDEILNRDERVEQLRSKLMNIEEDLKIKASKLTKARIEVATTLEKILLDELKSLNM
                     KNVMFKVNFEKGPFTLDGVDDIEFMISFNLGEDIKPIYKVASGGEMSRFMLAFKTILA
                     DIDDIDTLVFDEIDTGISGIAAQIVGEKLSDIAKKKQIICITHLPQIAANADTHYCIE
                     KDTSNNRTFTNVSKLNESQRKNEIARLIAGNNITEKTIEHASEIIELAKKC"
     gene            56862..57728
                     /locus_tag="KR257_001059"
     CDS             56862..57728
                     /locus_tag="KR257_001059"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861142.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0029778.1"
                     /translation="MNKKDTMHLIFIIVIFILLWYIVVAVSEINKNIESCSNKLDYLS
                     QELMSTKSDISNTINEEMSKSYITKSIDLKVKKIEKKECIIDIDVQLSKLGKNGKVFF
                     MYKEDSDKWNETEMTKHGELSYACEIKINTGSEYDYKVVTSGAISESSDVQKLTKSDY
                     MPEQPIFNSGIRDNREYFIEIVENSNLFNHESEKSKNKVYDNIRLEKVDIIVNEGKKD
                     TIYKAKLAEGLDDGKTNNSNRNQVNYEVSFPKRDIDDIIYIKAKLTYNNGVEYTKDIT
                     EDITMGLQDLEK"
     gene            complement(57821..58312)
                     /locus_tag="KR257_001060"
     CDS             complement(57821..58312)
                     /locus_tag="KR257_001060"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419191.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HBH0029779.1"
                     /translation="MADKMAQNITLQFVEEKDLENLENVKLLFTEYSNSLNIDLCFQD
                     FNNELKTLPGKYKKPSGSLILAFVDENLAGCVALKKLEGKICELKRLYVRNQFRGLKI
                     GKILLEEIIEEAKKFGYTHMRLDTLPSMKSAQGLYEKFGFYDIEPYTYNPIEGARYME
                     LKL"
     gene            complement(58373..58813)
                     /locus_tag="KR257_001061"
     CDS             complement(58373..58813)
                     /locus_tag="KR257_001061"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861143.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HBH0029780.1"
                     /translation="MKLNVRIADINNWHDLVSLSVDKSQLDYIESNALSIAESKFITA
                     WVPVGIYDENSLIGFAMYGRLEDDRVWLDRFMIDSKYQGKGYGKASLDFLVNHLKNEY
                     NCDELYLSIFEDNKMAIKLYKDFGFEFNGELDYGGEKVMVLKSN"
     gene            58974..60032
                     /locus_tag="KR257_001062"
     CDS             58974..60032
                     /locus_tag="KR257_001062"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428391.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptidase S55"
                     /protein_id="HBH0029781.1"
                     /translation="MNKINKNFKNIWIILGAVSIFTMVIIFNKNCNVNKETQIEAFTI
                     KNHDKKFVYPMGNIIGVKANTDGVLVLGYEEEDVDYIGGIQIGDNIVKIDNKRIKNSQ
                     DVSEILNKIKKSKVEVTFERKNKYKTEVIETKKENGKYKLGLWVRDKISGIGTMTFYD
                     PSMEKFKAIGHAIKDSDTNELLKIKQGYIYKPEQLKIVKASNEKVGKIKGDFNDSNLM
                     GNFSNNSELGISGNITENHNKEFNVANKEKQLIEVGRPQDVKIGGAVILFEDKNKNIT
                     SYDIKIESIVYDKGNYRDMVIKVVDDKLLEYTGGIVQGMSGAPIIQNNKIIGAITHVF
                     RDNPKKGYGIFIDEMIKL"
     gene            60174..60998
                     /gene="spo0A"
                     /locus_tag="KR257_001063"
     CDS             60174..60998
                     /gene="spo0A"
                     /locus_tag="KR257_001063"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419197.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sporulation transcription factor Spo0A"
                     /protein_id="HBH0029782.1"
                     /translation="MGGFLVEKIKIVLADDNKDFCQVLKEYLSNEDDIDILGIAKDGI
                     EALDLVKKTQPDLLILDVIMPHLDGLGVIEKLNTMDIPKMPKIIVLSAVGQDKITQSA
                     INLGADYYIVKPFDFVVFINRIRELVSNRVTQVEPKPRPVQETQMTRSDFVKNVGNIE
                     TEITNIIHEIGVPAHIKGYLYLREAIKMVIDNVELLGAVTKELYPSIAKKFNTTPSRV
                     ERAIRHAIEVAWSRGKVDTINQLFGYTVHNTKGKPTNSEFIAMIADKLRLEHSMVK"
BASE COUNT        24433 a         6422 c        11182 g        19047 t
ORIGIN      
        1 atgacaacat taataaaaca aaaatttatt tttaaaattt gataaatagc tgtatattag
       61 tatttataga ttaaatatta atatacagct atttattatt tttaagtcta ttgtagaata
      121 taaaccttgc aatatagagt actatgtaat attatagtaa atataagtac tatacattat
      181 agagtagtag gtgaaaaggc ggtggtacat aatgcagtta aataaagaag tgttaaaagg
      241 ttatatcgat atattaattg tttctatatt agaaaagaaa gattgttatg gatatgaaat
      301 tgcaaagcaa gtaagagaaa gaagtgagtt tgaattaaaa gaaggaacaa tgtatcttgc
      361 acttaaaaga atggaatcta aaaatttaat taaatcttat tatagcaatg aacaaagttc
      421 aggtggaaga agaaaatatt ataatttaac taatgaaggt aaagattttt tagaaataaa
      481 gaaacaagaa tggagattta ttaaaaaggt tatgaatcaa tttttgggag aggtggatta
      541 atttatgaaa ctaatagatg aatatttaga taaactatat aaaaaatgtg acaataaaag
      601 tactatagaa ttaaaacagg aaatgagatg ccatcttata gaatctgcaa atgaatttaa
      661 attagaagga ttagatgaag aagaagcatg taaaaaagca attgaaagat ttgatgatgg
      721 tgatgaaatg cagtatgaat tatgtaatat aataaaagaa ctatctttat cattggatag
      781 gcataaatca attgtaatgg ggtttaaaaa agtattaggt tacataagta taattgcatt
      841 tttaatttct ggatttatgt ggtattacaa taatagttta caacataata tgtataattt
      901 aggaaaagaa cttgatggag aaataaagca attggcagaa agacatgata tgacaaagat
      961 tggtgaatat aagttagaac ttgaaaaaat acttgataaa gataagtata gtaaagtcaa
     1021 agctcttaga ctatatgtaa tagatatgaa agatggaaac actaatttaa gttcttctgg
     1081 attgaatgct aatatggtat atgagaggga agcagattat aataacataa gtaattttat
     1141 acagcattta ggatataatg gaaaagattt tttagacaag aatgggaata tagtaaatcc
     1201 agatattttc ttagaatatt tcttttattt tgaatcggag atgttaattc cagtagcatt
     1261 tgcatttgga ttattatgta taatagcgta ttttatatta agatttaaaa tttctttaat
     1321 aaaaaataat aattaaataa ttcaccaaat aatcttaatt tgtagagtaa ataagatgtt
     1381 tcaaaataaa atttgaatca tcttattttt tattgtttgt tatactcttt tcttttatat
     1441 ttctccatag tggattgtat ctatacataa tcacatattt tgatataatt atactttcca
     1501 aaaaatgtat tgaatataca aattataatc tgtataatgt tgttagggga gaatgtatga
     1561 agtgtataca attttaattt taaatgtatt attgacaatt ctcctcactc tcgccattac
     1621 caataattgg aaaattgaca tacctgttac agaccaacat ttttgaatat attaattatt
     1681 atcattttat tgtgatgata tcaaaaatgc aggtttgtga gttggattgt atacgaacta
     1741 tataggaaat atagaacaga ttttccaaga aatctaaata ttctatgacc acgtgaattg
     1801 ctatgcatac atgttgataa tccatatttt aaatctaaaa tgaacttaat taatggtagg
     1861 gaattgaaag taaaatatat tataaaggag aatgctaata tgaaaaaaat caggaaatta
     1921 gctactaaac tattgattgc aatgatggtt ttaacctcat gtatgagtgt aacagtttat
     1981 ggtatgacag ctaaagatgt tactgcaaag acaccgaaaa gttatgtagc tggaaccaac
     2041 agtatatatg gtccaaagtt atcacaagct caacttaatt cggtagcaca agcaacagca
     2101 gactttatga acaagaaaat tacaaagaac atgaccacag atgctaagat tagggttgct
     2161 tataatcaca ttaaaaacaa cacaacatat gttaactgga acgcagcaga gggagccaat
     2221 actgcttata cattggttac taaaaaaggt gcttgttctg gaatgtgtag gagcttgaaa
     2281 gctttatgtg atgctatggg aattgaatgt tattatgtac atagtacaac aaatgaccat
     2341 cagtggaatc ttattcgttt tgaggatgga cgtttgtatc atgtagatat tgatgccaac
     2401 aaatcagcag gagcagacat catatacaag agtcttactc acccattacc atttgacaag
     2461 aaagcatatc cagctgttgg cgaagtagta aagacacaga atccaacgcc aactgttaag
     2521 aaacctacgc cagctaagcc ttctgcgcca gttggacctg ggaatcacac tatgatagca
     2581 gatcaacaag gggcaatact tgatgaagtt tatggaaata atctacgtcc aaaaattgaa
     2641 atgtatgagg gagttccgtg tagtttaatc aactcatcaa taaatacaat taagtttaca
     2701 agcaaaaatt caaatttaga cccatcaaag catacagtta ctgtaatagg gtttatgaat
     2761 acaccatatg gtatggttgc attagctcca gatggtgtac ctgatgagta tccttttgaa
     2821 tatgataagc cattttcttt agattttact ggtaagaacc tttctgcagc agaattatca
     2881 aaaaagtgta aagaaaataa tgtaattatt aaagtggaaa ttggtgaaac ggcatctaat
     2941 tctggaagag ggatggtagc atacgctaga tatgtgaatt aatacaaata tactagtgta
     3001 caaatagaac atattataaa taatgcaccc tcgcacaaag ggtgcattta tcattatatc
     3061 agtcatttta gaaaataaaa aaggagttga acttaaaatt agattagaaa aattaatttt
     3121 gagacaactc cattttaatt tatttttaaa tataaaatca tttattttaa ataatattat
     3181 gtttgattaa tggctattta actaattttg caaattctgc accaaatgcc atacactctt
     3241 ttaatgtctc ttcactaggg aagaattttt tcttaagaga ttctacaggc attttgaatg
     3301 acatagattt aagtaaagtc tcagccatag ttataccttc accactccaa ccaaatgaac
     3361 caaatactcc tgctatcttg ccttggttag ccattgggtc tataacagag aataaatccc
     3421 acataggttt aaccatagtt ttgtttatag ttggagaacc tagtaatatt acttttgaca
     3481 ctactaatgt atcgtgcatt tctgttaatg tcatatcttc taaatcatat aattcagcct
     3541 ttgcaccttc tttatcaagt ccttctttta tctttttagc catctctaaa gtattactat
     3601 aagctgataa gtagaatata gaaacttgat tttgattagt tgtattaaca gcttctgtag
     3661 accactcaac atatctttta acagcagcca ttgggtcttt agtaagcatt ggaccatgag
     3721 aagtcaatat agtatcaaat tctatgttta gtcctaccac cttatctaca gcacttaaaa
     3781 catgtttagc aaatggctta actatacaat catagtagtg tttagctgat tttagataat
     3841 cttcactatt cactacctct gcatcaacac ttgcaaagtg acaaccaaat gcatcacaag
     3901 ttaaaagagt cttgtcctcc tcaatgtaag taaacattgt atcaacccaa tgtaagaatg
     3961 gagcagttat aaatctaaga tttcttttac cgatatttaa aatttcacca tcttttatta
     4021 catgacagtt aaaaggtcta tttatttgac catctaagta tagtttagca gctttagtac
     4081 aataaacttc tatattagga tttatatcta ataagtattt taaactacct gcatggtctg
     4141 gttctgtgtg atgaattaca acatagtcaa ttttagctat atcagtaacc tctgataaat
     4201 tacttaaaaa ctcatcttta aaatttgcct ttacagtgtc aaataaaacc gttttttcgt
     4261 ccttgattaa ataagagttg taagttgtcc caaactcagt ttccattatt atgtcgaata
     4321 cttttaaacc ttcatctact actccagtaa agtagatatc tttttttact tcaaaaactt
     4381 tactcatttt taaccctcct aaaatttatc attatataag taacataccc cattttgagg
     4441 tgaatgaaac aaaagatgtc atgataagtc atgtaaaaca atagttttat gtttataata
     4501 tatcatactt tgtaaaaaaa ttgtatttca ataaaaattt aatagaaaat attcttaaat
     4561 atttttagct attctatttt gtgaataata tgtattttaa attcaatatt ttagttatat
     4621 ttttgataga aaatatttta tcgtgtataa tattacttat aaataagaat aaaaataaag
     4681 agcttgtttg gaggaatttt aataaatgaa taaagtagac ttgaaaaaaa tcttaaaaaa
     4741 agtagaaaag cctgctagat atcttggaaa tgaaataaat tcaattcata aagatactag
     4801 taatagtgaa ttgataagat atgcacattg ctttccagat ttatatgaag ttggtatgag
     4861 tcacttaggg agtcatatat tatatgatgt aataaataag gatgaagatg tattttgtga
     4921 gagagtgtat tctcctgcag ttgatatgga aaatataatg agagaaaaaa gtataccatt
     4981 atttgcatta gagtcaagag agcctataac aaactttgat tttgtcactt ttacacttca
     5041 atatgaactt tcatacacta atatcttaaa tatattagat ttagccaata taccaatatt
     5101 aaaagaagaa agaactttgg aagacccatt tataatggtt ggtggtcctt gtgcttataa
     5161 ttccgaacca ttagcagatt ttgtagatgt agtaatatta ggtgaaggtg aagaggttaa
     5221 tttagaagta gtaaatgagt ataaagaatg gaagaaaaat aaaacgacta gagaagattt
     5281 tttatataaa atatctagca tagaaggagt atacatacca agtttttatg atgtcaagta
     5341 caatgaagat ggtacagttc aaagtgtaac tcctaataga gaagggatta ctaaaaatcc
     5401 tactaaaagg ataataaaag atgttgagac tgtagattat ccagaaaaac taatagtacc
     5461 ttatatagat actgttcatg atagaatagt actagaatta tttagaggat gtactagagg
     5521 atgtagattc tgtcaagcag gtatgatata cagaccaata agagaaaaga gtgttaaaag
     5581 acttaaagaa atattagata aattagttaa gaatactgga tatgatgaaa tatcattatc
     5641 atcacttagt acgagtgatt atagtaagtt atcagagttg actgattatt tggtagatga
     5701 atatgcatct aataatattg ggatttcgct tccatccctt agattagata atttttcaat
     5761 ggaaattgct gataaaatac aacaagtaag aaaatctgga cttacttttg ctccagaagc
     5821 aggaactcaa agacttagag atgttataaa taaaggtgtt acagaagaag atttggaaaa
     5881 tgcaacagaa agagcttttg agatggggtg gaatagtgtt aagttgtatt ttatgattgg
     5941 tttaccaact gagacttatg aagatttaga tggtatagct aaattagctt ataaagttat
     6001 tgatatttat agaaaagtaa atggaggaaa gctaaagaga agttttagtg ttacagtgag
     6061 tacttctaca tttgtaccaa agccatttac acctttccaa tggcatggtc aagatactac
     6121 agaagaagtt attaataagc agagacattt agtaaataaa ttaagaaata acaatataaa
     6181 atacaattat catgattcaa agactagttt gatggaagca gtagtagcta gaggcgatag
     6241 aagaatagga aaagttatat atgatgcatt tagactaggt gctaaatttg atggatgggc
     6301 agaacatttt aatttagata tatggaaaga agctatggaa aagaataatc tttctataga
     6361 tttttatgca catagaaata gaaactatga agaggtattt ccttgggacc atatagatgt
     6421 aggtattagt aaaaaattct taattagaga agacgaaaat gctaaaaaag aaaaaatcac
     6481 ttctgattgt agacataact gcaatggttg tggaataaat atacatgata taggaagggg
     6541 gctttgctaa tatgagtaag ataataagag taaaatttaa aaaggaaggc gacatgatat
     6601 atatatcaca tcttgacctt cagagattgt tacaaagagc gtttagaaga gctgaaataa
     6661 acttatcaca ttctcaagga tttaatcctc accctaaaat gagttatggc aatgctttgg
     6721 ctttagggac agaaagtcaa ggtgagtatg tagatattga aatagaagaa gatgatttat
     6781 cagtagagga atttttaaat aaagtatcaa ttcaacttcc agatgggata gattttatca
     6841 aagcaaaaga aattgataga caaacacctt ctctttcttc tgtgatagac tatggagaat
     6901 atttgtttaa tatagatttg aaaagaccta tgacgaaaga gtttgtaaaa agaaaagtaa
     6961 ttgactttat gaataataaa gaaataatca taacaaaaaa gaataaaaaa ggtaagatgg
     7021 ttgaagtaga tataagacct atgataagaa cctttgatgt tttaaattta gaagatgaac
     7081 atattactct tactgctact atagctacag gctcaaaaac taatttaaat actaatatac
     7141 ttataccaaa gatattagag atgtttgaac ttgatattga cccattagat gttgatatat
     7201 tgagaagaga tttatatgta ttagaagatg gggaattagt gactcctatg taagctcgag
     7261 aggtgaagtt gtgaaaaaga tagttattga gtccctaata gggtcccaga aaacagcagt
     7321 acttgaagat gaaagattaa cagaactttt tgttgaagac aatttaaata agaagactgt
     7381 atccaatata tatcgtggaa tcgtaaaaaa agttatacca ggaatagaag cttgttttgt
     7441 agatattgga tttaagaaac ttgcttattt acaattaaaa aagggaagta ctataaaatc
     7501 tggtcaggat attttggttc agataaataa agaagaaata ggaactaaag gcgcaaaatt
     7561 aaacactgag attagtattt ctggaaggta tattgtctat ataccttcca atgatagaac
     7621 tacaatatca aataaaatta ctgatgaaaa agaacgattt agattaaaaa aaattactaa
     7681 ggcagtaaat aaggaaaatc taggattaat aataaggact gaggctcaag gttgcactca
     7741 tgatgaaata aagaaagata tagaagagtt gaaattaaag tatgaaaaca ttttaaaaga
     7801 atataaactt ggtataggtc cgaaattatt atataagtct ttagattttg caactaaata
     7861 tgtaaaagat aatgtgaatg atgatattga atctataatt accaatagtt atgataagta
     7921 ctctgaactt aagtctattt taagaggtat agataagact tatgttgata aactgtgtct
     7981 tgaggaaaat agagatgtat ttgatttata cagaatagaa tctaaaatag aaaaattatt
     8041 aaataaaaaa gtatggttaa agagtggagg ttatttaata attgaaaaaa cagaagctct
     8101 tacggttata gatgtaaata cgggtaagtt tattggaact ggtaaacttg atgaaaccgt
     8161 ttataaaact aatcttgaag ctgcaaaaga aattgtaaga cagcttagaa ttagagacat
     8221 agctgggata ataataatcg attttattga tatgcataaa aagaagcatc aaaaggagat
     8281 tttacacatc ctagaagaag aatttaataa agataaaaga aaagctgaag tattaggtat
     8341 gacaaaactt ggtttagtag aagttgctag gcgtagagaa aaagaatcca ttgataagta
     8401 ttatttaatg tcttgtccat gttgtgatgg tgaacaaaca ataaaatctg tacattatat
     8461 actagatagt attgaaaaag aaattatgag aataagtgaa catactgttt acaaaaacat
     8521 aatggtagaa tttaatgatt ttatttttga acaaataaaa gaatattata tggatataat
     8581 tgataaaatt ggtgaaaaat ataatataaa gatttcttta aacgcaaata gtacattaaa
     8641 gcacaataaa accaatgtta ttttcgataa aatagttgac aataaaatgt aaatatttta
     8701 taattaataa ttgtaatgcc gcacagtaaa ggtttaaatc ttcaaatgaa gtaccttgta
     8761 ctggcgagtt tgaggccgag gaggtgtatt taatgtacgc tatagtaaag actggtggaa
     8821 agcaatataa agtttctgaa ggtgatgtat tattcgttga aaaattagaa gctaacgcag
     8881 gtgatgttgt tactttaaac gaagtattag cttgctctaa agatggagaa ttaaaattag
     8941 gttctccagt agtagaagga gcatctgttc aagctaaagt tgttgaacaa ggtaaagcta
     9001 agaaagttat agttttcaag tataaagcaa aaaaagatta cagaagaaaa caaggacatc
     9061 gtcaatcata cactaagata gttgtagaaa aaataaacgc ttagttattg gttaagttat
     9121 gataaaagtt aaatattatt ataatgatga tttcttgttg caaggttttt gtttaaaggg
     9181 acatgctgat tttgctgaaa taggctatga tatagtatgt gctgcagtta catctaatgc
     9241 tattgcagtt ataaattctt tagacaaatt acaaaagatt gaatttgaaa aagtagtagg
     9301 agaagaaggt catatagagt gtatagtcaa agatacacat gtaaaagacg cacaattatt
     9361 actaaatcac tttcaattag cggttaaaga aattaaacgg gaatacccaa aaaatataaa
     9421 aattttaaaa aagtaggggg tgactccata tgttaaacat gaatttacaa ttattagcat
     9481 ctaaaaaagg ggtaggttct tctaaaaatg gtagagattc tatatctaaa agattaggtg
     9541 ttaagagatt cgatggtcaa ttagtaactg ctggaagtat aatagttaga caaagaggaa
     9601 ctaaaataca tccaggaact aatgttggaa aaggtagtga tgatacttta tttgcattag
     9661 ttgatggtac tgttaaattc gaaagaaaag acaagaagag aaaaaaagtt agtatatatc
     9721 cagtagctat agctgagtaa tatacataaa aggagtgttg aggcactcct ttttcttata
     9781 atactgatga atttataatg gtatttttgg taatgctaat taaaagtttt taattaagta
     9841 ggtgaagaat ttgtttatag ataaggcaag aatatttgtt aaggctggaa atggtggaaa
     9901 tggttcggta gcatttagaa gagaaaaata cgttccagct ggtggtccag acggtggaga
     9961 tggtggtcgt ggagcaagca tcatatttga agttgatttg gggcttagaa ctctaatgga
    10021 ctttaagtac cagaaaaaat atcaagctca aaatggtggc gacggaagca aaggaaaaag
    10081 agctggtaaa aatggagaaa atttagtatt aaaagtacca gcaggtacag taataagaga
    10141 tgaggctaca ggtcttgtat tagcagattt aaaaaaagaa ggagatacag ctatagttgc
    10201 aaaaggtggt ataggtggta aaggtaacca acactttgca aatgcagtaa gacaagctcc
    10261 agcttttgca aaatctggta cagatggaga agaaagatgg ataactcttg aacttaaaat
    10321 gatagcagat gttggtcttt taggatttcc aaatgtaggt aaatcaacat ttctatcagt
    10381 tgtaactaaa gctaaaccca aaattgcaaa ctatcatttt acaacactta caccaaatct
    10441 aggtgttgtt caaactaagt ttggagatag ttttgtactt gcagatatac ctggaattat
    10501 agagggtgct tctgaaggca taggattagg tcatgagttc ttaagacatg ttgagagaac
    10561 aaaggtattg atacatattg tagatatatc tggattagag ggaagagacc ctattgaaga
    10621 ttttgacaag ataaatgatg agcttaaatt gtacaatgaa aagctttcaa agagaccaca
    10681 agttgtagtt gcaaataaat ttgatatatt agaagatgag agtaagtttg agaagtttaa
    10741 gagtgaatta gaaggcagag gatatacagt atttaaaatg tcagcagcaa ctcgtcaagg
    10801 catagatgaa gtaatagcct atgtttctaa aatgctaaaa gaagtagaag atgtggagct
    10861 agtttcagaa gaagaaatgt atagaccaga acttgatatt ggtactgaag aagagttaag
    10921 tatagatatt gaagatggtg tgtatgtagt tacaggtaaa gcacttagaa gaataatgta
    10981 ttctgtaaat tttgatgata tggaatccct tcaatatttc caaaaagcta tggagagtca
    11041 aggtgttttt gataggctta gagaaatggg aatagaagat ggagatgtgg ttaaaattta
    11101 tgaattagaa tttgagtttt acaattaatt taaatataga ttatagataa tttaagtata
    11161 gaattataga ggtgagaata tgttaaaagg aaaacaaagg gcgtatttaa gatctttggc
    11221 aaatacttta aagcctacta cacaaattgg taaagaaggt gttacagaga gtttcttaga
    11281 gcaattagat ggtatgttaa gaactagaga attagtaaaa gttactatat tagaaaatgc
    11341 aggtcttgat actaaagaaa ctgctaatgc agtatgtgaa gctttaagag ctgaatttgt
    11401 gcaggctatt ggttttaaat ttactattta caagaggaat attgaagagc ctaaaatact
    11461 ttttccagga catgaacagg cgaaagcaaa gactaaaaat aataatgtta caaaaaaggg
    11521 taaaccaact aaaagagctg ttagataata gtttatatcc ttttagggaa ataagttaaa
    11581 aaaatagtga caattggaag aaattgtatt atactattaa acataaattt aaattagcaa
    11641 tcttatcaag agtggcagag ggactggccc tgtgaagccc ggcaaccagt atatttaatt
    11701 atacattggt gctaaatcct gcagcattta tgctgaaaga tgagtataaa cccgtcatat
    11761 ggcttgagtt tatactcaag ctttttttat tggtatattt atatatataa ataatttaat
    11821 ataatcaaaa tgatgggggt atgttacagt gaagatagca atattagggt atggaacagt
    11881 aggaagtgga ttaattgatt taatagaaaa taatacttca aaaagagata tagaagttgt
    11941 tggaatttta gttaaaaata aagaaaaaca caagtataag aagtactttg ataagataac
    12001 tactgatata gaagatatat ttgacaagga tattgatata ctagttgaag taattggagg
    12061 attaaatcca gcttttgatt atgtaacaag agcgttaaat aaaaaaatac atgtagtgac
    12121 agctaataaa gatttactgg ctgaaaaagg tagtgacctt atagaattag ctaacttaaa
    12181 taatgttagc atcaagtttg aagcatctgt ggcaggtggt attccagttt taaaaccatt
    12241 gatagaatca ctggaaggca acaatataaa gagcataaac gctattttaa atgggacttg
    12301 taattttata ttatcaaaga tgtatgatga aaatttaccg tatgatgtcg ctttaaaaca
    12361 ggcacaagag ttgggatttg cagaagttaa tccagatgca gatgttttag gatatgatag
    12421 tgctagaaag ttatctatat tgtctacttt atcttatgga aaaatagtat attggaaaga
    12481 tttattatta gaaggaataa cttcaataga tgaaaaagat atagaatatg caaaaaaatt
    12541 aaattgtaag ataaaattgg ttgctagaag taagtatgaa tcaggagaag taagtggatt
    12601 tgttagacca gcattagtgg acaataataa tatgctttca aagatagata atgagttcaa
    12661 cgtagttatt ttagtaggtg attcagtagg tgaactttct tttgtaggta agggagctgg
    12721 aagaggtgca acaggaagtg ctgtttatgc agatattata gatataatag ataatagaag
    12781 ttcaaatata aagtcttttt caaaagggaa attggattta agtggactta tagaagatga
    12841 gtgtagtgca gtagttagat ttggtgggta taataataaa gatggaattt tagaatgttt
    12901 agataaatat gtagatagtt atgatattat agatgatgaa gaattggcga tttttgtaag
    12961 tgcaaagtca gaacatgaga ttgatagagt tttggaaatt gtaaaaagaa ataattacag
    13021 tgaatcagct aaaaaattat tgaagataga ttaatatgtt tatgcaagaa ttatgaaaat
    13081 ttaatagggt gtctcaaaat agagagataa gccttttttc cagtgttgaa ataataaaaa
    13141 tatatttgat tttataaaaa aagagtgtct tatgaactaa aaagttcatt ttgagacact
    13201 cttttttaat atctggtgaa ttaataagat aatagaaaaa tgtatacgtt ataattaacc
    13261 aataaagaaa ttttcactag cttcattaat agcttgctga gttaccctta tatatcgctg
    13321 tgtagtggct acagagctgt gatttaaaag ttctttaacc aactctaaat tattgttact
    13381 cttttcaaat tgagtagtag catagagctt tctaaagcta tgtgtactta tattatacag
    13441 atttaagtgt ttacaaatta tcctcaactg tttttgaata gcctttgtct ttatatttac
    13501 taagtagtca tttgatttaa gattatactt tcttgcatgt tcatttatgg actcaattat
    13561 atttttatta actggtctat actgtaattt gcccgtcttt ttttcattta tttccaacat
    13621 attaccttta aaattaccta tctttaatct taaaatatct gatattctta gacctaaatt
    13681 agcttctaac attagtgcca atgcaacttt aggatttttt ctaaatcttt tttcaacgcc
    13741 attttcacta taagtaaagc cagtatgtaa tagttccatt atctttttat attcgtctat
    13801 ttctataggt cttgttgcca ttttcaacca ctcctcttag tttgatttgg taagtttagg
    13861 tcggtattta ttatataata taaatgaaat attatataat ggaaaaattt cccagtaaac
    13921 ttatacaagt gtgatatatg tgattaagga gaattttttg aaaaatattt ctaataaaat
    13981 tattaaattg tgatgaaata actatgctgt taaactaatt aaaaaggtta ttaaaattat
    14041 gacaaatata ataaaaaaat ggaagtattt agttaagttt tattagtttt atttttagtt
    14101 ttattttttt cgtgaaaatt tcttagtgaa aaaagtattt ttatatcgca ttagtttccc
    14161 atttgtagat aaagttttca tatgtttttt tgcaataaat acggctgaga ttagataaat
    14221 tattactaca atttgaagaa ttgtatcata atagctaagg taataaaacc agattaaatt
    14281 attatatata acgttgtatg tatcagcaaa gctagaaacc aacacagcag agtttgcaat
    14341 tggataaagt ataaatataa agatagcagc taaaactcca tgcgcaaatt tacttagtat
    14401 gtataatttt aaatctatgt ccgtttttga tagaaatgta caacattgag ctaggatgga
    14461 taatccacta aatcctatca aaaaactagc taaagatgct cttaaaattt ctggagaact
    14521 tgttatacta gatactttat tgcatcctat agtaatttca aatagaccac ttacaaatgc
    14581 ttgacagagt tctttactaa cacctaaaaa tgaaagaggc aaatatataa ctgatgctat
    14641 taatgagatt acattaaaaa gagatagtat tttaaatact actgaaaaaa caattacaaa
    14701 tccaccaact gtaagtaatg tgtttactcc attaaataca gcatttccaa ataaaacaaa
    14761 aaaaccattc ccacttgaat ttctaatgtt gattacattt tttatatttg tttttaaatc
    14821 caattttgtc tttggaaggt tttcattacc ataatttcta aagaaaagac caaccaatat
    14881 agttcctaga taatggcaga gaatcattaa ataacctaag tttgaatttt ggaacatacc
    14941 tgtaccaacc gaacctatta tgaataaagg tcctgatgta gaacaaaaag acacaagtct
    15001 ttgtgcttca tacttagaaa tttgtccatt actcctaaat tcagaagcta aacttactcc
    15061 tactggataa ccagatactg tagatatagc aaaagctaaa gcgctctttc ctgaaacatt
    15121 aaatacaaat ctagttatgg gattgatgat aaaccctata atatccacta tttttaaatc
    15181 aacaattaag tttgctccaa ttataaatgg tagtagtgat ggaactaaaa cattagacca
    15241 tatagaaaag ccttctcttg cagattttat agcttcattt gggtatagga taatccctaa
    15301 aactagaact ccaactatga tagatggagc aaaaaaagca ataattttat tttttttcat
    15361 aatatcacct gtaaatttga gttataagat attatattaa aagtaataaa aatatatgaa
    15421 tgtaatggct taagatatat aatagatata tattacaaca acgattatca tattggagga
    15481 aaaaatgttt aatagtatag ctagtaaaaa agtttatgaa caagtaattg agcaaataca
    15541 atataaaata ctaaatggag agttaaaaaa gggggataaa ttactatcag aaagagaact
    15601 gtctgaacaa atgaatgtga gtagaacttc cataagggaa gctattaggg tattagagac
    15661 tatgggagtg atagaaagca gacagggtga aggaaatttt atatgtacaa atatagaaaa
    15721 aactttaata gaacctttat ctatgatttt taaacttaat aatggtacac ttgaagatat
    15781 attagagctt agaataatcc tagaaattga gattgcaaaa cttgcttcaa agagaataac
    15841 ttcttctgaa gttatagaat tgaaacatat aatagatgaa atgagggtag aaactaataa
    15901 aaaagataat aatcgagtac tggtattatt agaccaaaaa tttcacagta aactagcaac
    15961 attaagtaaa aattatttaa ttcaaagtct ttttatgaca gcatcaaaat tatttgatgg
    16021 atttatagaa gatgcaagag aaaaaataat cgcagaacct tttaatgaaa atatattgct
    16081 taaacagcat gaagctatat acaatgcagt tgtagaaaat gatgtagaac ttgcatgtga
    16141 gaaagcaaag gaacatatgg attttataag taaaaattat agaaaaaatg aaaattaaaa
    16201 gtttgttata aaataaatta ttcttgcaaa tggtagataa tggtactatt atataaatgt
    16261 aaaactggta tgaccacata ccaattttat agtttattat aatgggagat taaaaatggt
    16321 aaagttaaaa gtaccgtatt caaaacaagg aatgatttta gaaatacctg atgaacgttt
    16381 tctcggtgtt ttggagtcaa aatcggataa ttatatagaa cataagactc aagaagagat
    16441 agttgaagaa tctatgaata atcctatagg ctctaattct ctggaagaac tggttaaggg
    16501 gaaaaagaat gtagtcataa ttacaagtga ccatacaaga cctgtaccaa gtagaataac
    16561 tatgccaatt atattaagaa ggattaggaa tgttaatcca gaaattgatg tgaagattat
    16621 agtggcaact ggatttcata ggccaagtac aagggaagag ctaatttata aaatgggaga
    16681 agaaatagta gataatgaag atatagttat gcatatatct actgatgata aatctatgtg
    16741 taaagtaggg atattgcctt caggtggaga tttatatata aacaaactag catatgaggc
    16801 agaacttttg atagcagaag gttttataga acctcatttc tttgcaggtt tttcaggtgg
    16861 cagaaaaagc gtacttccag gaatcgcatc tgcaaagact ataatgtaca atcactgtag
    16921 tgactttata gatagtgata attcaagaac tggaaaattg aataataatc ctattcatga
    16981 ggatatggta tatgcagcta aagttgcaaa attagcattc atattgaatg ttgtaataga
    17041 taaagataaa aaaataattg cttcctttgc tggtgatgtc gaaaaagcac atactaaagg
    17101 atgtagattt gtaacagagt tatcaaaagt aaattctata aaatctgata ttgttgtaac
    17161 tacaaatggt ggatatccac tagaccaaaa tatttatcaa tctgttaaag gaatgacagc
    17221 agctgaagct acttgtaaag acggtggagt aataataatg atttcagcat gtaatgatgg
    17281 tcatggaggt caatcttttt atgaaaatgt agcaaatgca gattctccaa aacaactttt
    17341 agataaaatt agaagtgtcg atagagtaga tacgattcca gaccaatggg aatttcagat
    17401 actagcgaga atattatcta aatatactgt gataatggta acagataagt gtaatcctga
    17461 aatgataaaa aaaatgcata tgaaacatgc atttaacttt aaagaagctt tagaaatggc
    17521 gaatagtata gttggtaagg agagcaaagt agtagttata cctgatggag tatcagttat
    17581 agttaaataa aaaaggagtg tactttatgg aaattttgac atgtattaaa caagttcctg
    17641 gaacgacttc agtagaagtt gatgaaacta caggagtact aaaaagagat ggagtagatt
    17701 caaaaatgaa tccctatgac ctatatgctt tagaaacagc tcttagaata aaggaagata
    17761 agaaagcgaa tctaaaagta cttagcatgg gtcctcctca ggcaaagaag gtaattgaag
    17821 aaagttttat gatgggagct gatgaaggag cattaataag tgataggaga tttggaggag
    17881 cagatgtatt ggctacttcc tataccatat cacaaggtat taagaagatg ggaaaggtag
    17941 acctaataat ttgtggaaaa caaactactg atggtgatac agcacaggtg ggacctgaag
    18001 tagctgaatt tttagatata cctcatgtta ctaacgttac aaaattaatt gaagttaaag
    18061 atgaaagtat agttgttgaa atagatatgc caaatgattt acaagtatgt gagattgaat
    18121 atccatgttt aataactgta gaaaaagaca tttttcaacc aagactacct tcatttaaat
    18181 taaaacttaa tactaaagat agagaaatac ctgtatatag cttagatgac tttgaagata
    18241 aaaatgaaaa taactatgga cttaatggtt ctcctactca agttgtaaga atatttcctc
    18301 caaagccaaa tacagataaa aatattgtaa gaggaaatgc agatgaacta agttttgcac
    18361 ttgtaaataa attagaggaa ttaaagttgg tgtaaggggg agtaataaat gtcaaagata
    18421 gttgtaaatc aagataaaat aactgactta aagagaattt tagaaatatg tccttttggg
    18481 gctatagaag aaaagtcagg tatagtagaa ataagtgctg gctgtaagat gtgcaagttg
    18541 tgtgtcaaaa gtggaccaaa aggcgcattt gaatttatag agagtagtaa agtacaaatt
    18601 aataaagatg aatggagggg aattgcagta tatgttgaac atcataatgg aaatatacat
    18661 cctgtaacgt acgagcttat aggtaaagct cgtgagatgg catcaaaaat aaaacaacct
    18721 gtgtattgtg tatttgtagg aaaagacata aaagataagt gcagtaattt gatttcttat
    18781 ggggtggatg aagtatttgt atatgatgaa gatgaattta aagattttag gatagaacca
    18841 tattcaaaag caatagaaaa ctttatagat aaaataaaac caacgatagt attagttggt
    18901 ggaactacat taggtaggtc attagctcca agacttgccg ctagatttag aacaggtctt
    18961 acagcagatt gtacaatact tgatattcaa tcaaatactg atttagacca aataagacca
    19021 gcatttggtg gaaatataat ggctcatata aacacaccta ataatagacc acaatttgcc
    19081 actgtaagat ataaaatatt ttcagcacca gaaaaaatag agaatactac aggaaagata
    19141 actttatgta aagtagaaaa aaaagaacta aaatctaaaa ttaaggtact gagtgtaaaa
    19201 gaaaaaaata aagaagttgg tctggaagaa gctgaagtga tagttgtggc aagtagagca
    19261 ataaaaaaac aagaagatat ggagatgata tataaattag ctgataagtt aaacgctcaa
    19321 gtggcaggaa caagacctgt aatagaagca ggttggatag atgctaaaaa acaaataggt
    19381 cttagtggta gaactgtaaa acctaaattg ataataactt gtggtgtatc tggagctgtt
    19441 caatttgttg cagggatgca gggtgctgac tatatagtag caataaataa agatgataaa
    19501 gcgcctatac ttgatgtagc acatttagct ttaataggtg atatttatga tattattcct
    19561 aaattgattg aaaaaataga aaataacaaa gataataatc aaaaatatat ggcatcagca
    19621 gctaaatagg gggatagaaa tgtataaatt aatcgataaa aaagatatag attttttaat
    19681 agatacttgt ggagaagaaa atgtattagt tggaagtgat ataaatgaag atttttcaca
    19741 tgatgaactt ggagggattg agaagtaccc tgaagtttta gtaaatgtac ttgaaactga
    19801 acaagtatct aaaataatga aatacgcata taaaaataat ataccagtca caccaagagg
    19861 tcaaggtact ggtcttgtag gtgctgctgt tgccataaat ggtggaataa tgattaatct
    19921 atgtaaaatg aataaaatac ttgaagttga ttatgaaaat ttaacattga cagtagaacc
    19981 aggtgtttta ttgatgacaa taggtcaata tgttcaagat agagatttat tttacccacc
    20041 tgacccaggt gaaaaaagtg ctacaattgc aggtaatata aacactaatg caggtggtat
    20101 gagagcagta aaatatggcg ttacaaggga ttatgtaaga ggtcttgaag ttgtactacc
    20161 aaatggagaa attataaatg taggtggaaa ggtggttaaa aatagttctg gatatagtat
    20221 aaaggattta ttagtgggct cagaaggtac tttaggaata gttactaaag ctatattaaa
    20281 attgcttcct ttaccaaaga aaagtataag tttgcttata ccatttccag atttatcaat
    20341 ggcaatagaa actgttccta aaataataaa atcaaaatca ataccaacgg ctatagaatt
    20401 tatggaaaga gatgtgatat tggcagcaga agaattttta ggtaaaaagt ttccagataa
    20461 tacatcagat gcttatcttt tgcttacatt tgatggaaat agcactgaag atatagaaaa
    20521 agaatatgaa aaagtagcta atttatgttt agaaaatggt gcattagatg tatttatatc
    20581 agatacacaa gaaagaaacg attctatatg gtcagccaga ggtgcatttt tagaagctat
    20641 aaaggcatct acgacacaaa tggatgaatg tgatgtcgtt gttccaagag ataagatagc
    20701 agagtttata agatacactc acgagcttca agacaaatta aaaataagaa taaaaagttt
    20761 tggtcatgca ggagatggaa atctacacat atatatttta aaagatggta tggatgataa
    20821 tacatggaaa ataagattaa aagaaacttt tgactatatg tataaaaaat ctagagaact
    20881 tagtggtcaa gtttctggtg aacatggcat aggatatgct aaaaaagagt acttacatga
    20941 atcaaattca gatgcttata tgatgttaat taaaaatata aagttagctt ttgaccctaa
    21001 aaatatttta aatccaggga aaatatatta gaaatattaa tttaataata tttacaaaac
    21061 aaaaaatatt aaattagatt taaatataat attttaaact ttacttttaa atctgaagct
    21121 aaattgtaaa atttttagga tggcaatatt tacttaaatt tagaaagtaa cataatattt
    21181 aagttgatgt tgtcatccta aaagcatgtg tacataaata aagtaagact attgtatctt
    21241 atataataaa gagttaataa aatgattttt ataaatatag ttattttaaa aaactacttt
    21301 acatatattg gatgagtata aaaatccata gggcctttta ctaaatcttt attgttttta
    21361 taatatattg aattatatat atttgtagct tttatatcat aacttatgag tgttttaaaa
    21421 atcgtatcat ctaatgaaaa tgatatattt gaaaacttgt ttattatttt tatttcagat
    21481 ttatttttta tctcttttag aatttctcta cctttatcat taaaagcaag tattcttata
    21541 taaggtatag tatctatgtt ttttataagt tgcatgtcgc tttttttaat acctaacaat
    21601 atattgttta gagttcgttt gattttggtt aaagtgtatc gcttggattt aattgctaat
    21661 tgtagttcat gtagaaattc agatgtaaag atatctttat agattctgtt ttctatgcct
    21721 tcatttactt caaaatactc ttttaaagtg tccatatctc taagtataat tgtttttaaa
    21781 atatcaaaga agaagtcatc aaacataggt aaaaaaccat tatctatttt ttcatttagg
    21841 atgttataag ttttttctgg aataacattt tttaaatgaa aaaggtctgt attttcttta
    21901 agtgaagttc ttatagcagt agcagaacaa atatcactct caatttcttc ggaattatac
    21961 tctgattgga ccctggagat agtaaatggt tttatactac tgtttaaatg gatgaggttt
    22021 tttatgtatt ctatacccag tatgttgttt gatgaattta atgtttttga taattgttcc
    22081 tttgaataat tttgtataaa attatttttt ttgtcttgat gtatataatc aaaaagtgca
    22141 ttagctctag ctgttggaaa taacagacca tcatctaaat atttttttaa aagtaactta
    22201 aattcatttg gttcatttgc taaaatttca gctatattat aaagaatttc tgtatttcct
    22261 tcttcactac caaaacatat agaatttatg cagtttagtg aatttaaaat tgttatagca
    22321 ccatgagaaa aaatttcagc actttgacaa gcaaataaag ttggtaattc tataactaag
    22381 tctacaccat tttcgacagc aatttttgct ctagtgtatt tatcaaataa agctggttcg
    22441 cctctttgta gaaaatttcc actcattatt gctacagtat gtgttgcatt tgttttttct
    22501 atagatttag ataaatgata tatgtgtcca ttatgaaatg ggttatattc aactattaat
    22561 ccaagtatgt tcataaaata ctccttttat ctttaattat tttatatata tcacaattta
    22621 ttataatatg tataaaattt aaatttttaa ttataaaatt aaaaaacgta aaaaaattta
    22681 taaaaatgta gaaatgttac ctacataaaa aactggttaa atgttattaa aataacttta
    22741 ttagctcttt atattatatt attataacaa atgggaaaga ataatctaca ttaagttaac
    22801 ttgttaatat attattagtg aaatacacaa tttaccatac tagaaatatg atataatata
    22861 aaaaaaaagt atatactttt atattaaaag gtgatatatt atttatgaaa atcgtttaat
    22921 gtatacaata atatatctat aacaaaataa taaaagatag agttttattt agacatttat
    22981 tacaaatcaa aatttattac atattattta taaaaaaatc taaggaggaa ataataatga
    23041 aaatattagt attaaactgt gggagttctt cattaaaata tcaattaata gatatgaata
    23101 atgaagaagt tttatgtata ggattggttg aaagaatagg aatagaaggt tctatattaa
    23161 aacatgaaaa agcaggtaga gatgataaat acgttgttga acaaccaatg aaggaccaca
    23221 aagatgcaat agcattagtt ttagaagctg ttgctcatcc agaatttggt gcagttaaag
    23281 aaatgaaaga aatagatgca gtaggacata gagttgtaca tgctggagaa aaatttgcaa
    23341 cttcagtagt aataactcca gaagtagaag aagctttaaa agaatgtata gatttagctc
    23401 cacttcataa tccagcaaac ataatgggaa tagatgcttg taaagctata cttccagatg
    23461 taccaatggt aggtgtattt gatactgctt tccatcaaac aatgcctaaa tcttcatact
    23521 tatatggttt acctcatgag ctatatacta aatatggggt aagaagatat ggattccacg
    23581 gaacttctca taattatgta tctcagagag cagcagagat attaggaaaa gatataaaag
    23641 atttaaaaat agtaacttgt cacttaggaa atggtgcttc tatagctgct gttgatggtg
    23701 gaaaatgtgt agatacatct atgggattca ctccattaga aggattaata atgggaacta
    23761 gatgtggaga tatagaccca gctatattac cattcttaat gagaaaagaa ggtttagatg
    23821 ctgatggatt ggataaatta atgaataaag aatctggagt atatggaatg actggaattt
    23881 ctagtgactt cagagatata gaagatgcag ctaaaaatgg agacgaaaga gctcaagcta
    23941 cattagaagc gtatgttaaa aaagtacaaa aatatatagg cgcttatgct gctgaaatga
    24001 atggattgga tgttgtagta tttactgcag gcgttggtga aaatggaaag gctataagag
    24061 cagatattgc ttctaacatg gagtttttag gaatgaaatt agataaagaa gctaatgatg
    24121 ttagaggaaa agaaacagta atatctactg ctgattctaa agtaaaaatg cttttaatac
    24181 caactaatga agaattaatg atagctagag atacattaag attggtaaaa taattaaatt
    24241 aaacctatgc ctatcaagta aaaatacttg acaaacaaat gctagatttg tataataaat
    24301 ttggtgatat gttgaggtga acttaatgaa agttagcata gaaaaaataa atagaaaaga
    24361 aactgacaaa atagacttga atttttgtga aaaaattgat actattagtt attgtgatga
    24421 gatttacaaa ttagtatcac ctgtaaattt aaaagggaaa gtgtcaaaga ctaataaagg
    24481 tttgtatcta gatatagatg tcaattttac aattgttgac aattgttcaa gatgtcttaa
    24541 agaagtagaa ataccactag agtattctat acaaggtttt ttagtaaaag aagaagatta
    24601 tgatgaagat gagtttgagg aatttgatcc ttttatattc gatggtgaag aaatcgacct
    24661 tattgatata atagaacaga cattagattt taatgtacct cataaagttc tttgtagtga
    24721 aaactgtaaa ggtctttgtc aagtatgcgg ggcaaactta aatgaagaag agtgttcttg
    24781 cagtgaaatt acaaacgatg aggaatacat agatcctcgt tttgctaaat taaaagattt
    24841 atttaattaa attttgacta aggaggtggc gtaaatggca gtaccaaagc gtaaaacgtc
    24901 taaatcaaac acaaaaatga gaagagcagc taactcaaag atggaagcaa caggatttgt
    24961 aagttgccca caatgtcatg agccaaaatt accacataga gtgtgtccag actgtggata
    25021 ttataaaggt aaagaagttg tgtctaagta atagcttcta aaaagcatgt agagtatact
    25081 ctacatgttt tttttgtaca tataaaaaaa taagatgatt tactagagaa aataagtgga
    25141 ttttatgcat attaaaaaat agaaaaataa taatataagt attgaaaatt tttgtgtgtt
    25201 actatatact actattagta gctggtacta attacagcta taaaatttgg agggaacatg
    25261 aaaaagaaaa gtaaagccca aagacaaaaa gagcttatag atatgctaaa gacagatcct
    25321 ttttatactg atgaagaatt atcaagtctg tttgatgtaa gtatacagac cataagatta
    25381 gatagaatga gtctaaacat accagagcta agagaaagag tcaaatcaat agcagaaact
    25441 cagagttcaa aagtaaagac tttaggagta aaggaaatta caggagaaat cattgattta
    25501 tctgtagggc gattaggtat atctatgtta gaagttacac aggacatgat ttactctaag
    25561 actaatactt taaaagatac gtatattttt tctctagcag attcattggc aatggctata
    25621 atagatgcac ctaaggttat tatgagagtt gcaaatgtaa aaagttttaa gttgatagaa
    25681 caacaagata gacttatagc aaaagcagaa gtgtatagaa atatagataa aaagcattat
    25741 gtaaaagttg ttatcaacaa taaagcccaa gagcaaatat ttagaggaaa gtttatcttt
    25801 gaagaattag attaggaggg aaattatgaa aatagtaatt gatggaatgg gtggagataa
    25861 tgcacctaaa tctaatgtag aaggcgcagt aaatgctata aaagaatatc aggttgattt
    25921 aataatcaca ggagataaag atttacttga aaaggaattt tcaaattatg aatttgatag
    25981 aaataaatta gagatagttc atactactga gattatagaa aacgaagata aaccagtaaa
    26041 ggctataaga agtaaaaaag attcatctat ggtagtagca ttaaatcttg taaaagaagg
    26101 aaaggcagat gctataatat cagctggaaa tacaggagcc ttacttgctg gtggattatt
    26161 tgttgttggt agaataaaag gaatcgatag accttgctta tgttcagcaa taccaaatgt
    26221 aaagcgagga atgacactta tagcagactg tggcgcaaat gcagattgta aacctaagaa
    26281 tctagttgaa tttgcagcta tgagtaatat ttattcaaga aaagttttag gtcttgaaaa
    26341 tcctaaggta gcattagcaa atgttggact agaagaaggc aaaggcaatg atttagtcaa
    26401 aaggtcatat gaagaaatta aaaaattaga tttaaatttt atagggaatg tagaagctag
    26461 agaagttata aatgcataca cagatataat catatgtgat ggatttacag gtaatatatt
    26521 acttaaatct gctgaaggtg tagcactttc agttatgagt cttataaagg aaacttttat
    26581 ggccagtaca aaaagtaaaa taggagcatt acttataaag gatgatttaa gaaaattaaa
    26641 aagttttata gattattctg agtatggggg agctccactt ttaggtctaa atggaggagt
    26701 tataaaagct catggtagtt ctgatgctaa agctataaaa aatgctataa atcaaggaat
    26761 aaaattttca aagggaaaag tcgttgaaga tattaaccaa tttataagca aatacaatga
    26821 agaaaataaa aataacgaag atgaataaac tcgttttgga ggtttaatat ataatgaata
    26881 caaaggctgg aatattagga gtaggaagtt atctacctga gcaatcatat gataattttc
    26941 acttcgaaaa aataatggat acatcagatg agtggataag tactagaact ggtattaagg
    27001 aaagaagatt tgccaaagag tctgaagcaa cttctgactt agcatctaaa gctgccttaa
    27061 aagctataga atgtgcaaag ttaaacgtag aggatataga gctgattata ttagctacaa
    27121 ttactcctga tatgtctttg ccttcaactg catgtatagt acaagatgca ataggagcag
    27181 taaatgctac tgcatttgat atatcagcag cttgttctgg atttgtatat ggagtaacta
    27241 ttgcaaagca atttgtggaa acaggttgct ataaaaatgt gcttgtaata ggagcagaaa
    27301 cttgttctaa gtttttaaat tatgatgata gaacaacagc agtattgttt ggagatggag
    27361 ctggagcagc tgttattggc cctgtaaatg agggtggaat actgtctaca catatgggct
    27421 ctgatggtaa aggaaaagat tgtttaaaag tacctgctgg aggttcaaga cttaaggcaa
    27481 gtaaagagac tgtagaagct aatctacata caatagaaat ggcaggtagt gatgtgttta
    27541 aatttgcagt tagaaagatg gcagaaactt ctttaagagc tcttgaaaaa gcaaatctaa
    27601 atacaactga tatagactac ttagtgccac atcaagctaa tataagaatc atacaagctt
    27661 cttctaagag attagagctt gatatgaaaa aagtttatgt aaatatagac aaatatggaa
    27721 atatgtctgc tgcatctata ccagtagcat tagatgaagc ttatagagaa ggtaaaatta
    27781 aaaagggtga taatgtagtt ttagttggct ttggtggagg tctaacttgg ggggcttcag
    27841 ttgtcaagtg gactttatag tataaaatat ctaaaatgat ttaattaaca aaattaaact
    27901 tatacacaaa ataaagttga ttaataataa aaagtttact tttatgattt caagtgaagg
    27961 agaattgtat gaataaaatt tgcaaaatat taaatataaa atacccagtt atccaagggg
    28021 gaatggcatg ggtagctact gcatcattag caagtgctgt atctaatgca ggaggacttg
    28081 gcataatagc agcaggaaac gcaccaaaag aagctataaa gaaagaaatt gttgagtgta
    28141 aaaaattaac agataaacct tttggagtaa atgtaatgct tatgtcgcca tttgttgatg
    28201 atataattga tttgattata gaagaaaaag ttcaagttat tactactggt gctggaaatc
    28261 ctgcaaagta tatggataga ttaaaggaag ctggaacaaa ggttattcct gtagtaccta
    28321 caatagcttt ggcacaaaga atggaaaagc taggagctac agcagtaata gcagaaggta
    28381 ctgaaggtgg aggacatata ggagaactta ctactatggt cttagttcca caagttgctg
    28441 atgctgtaaa catacctgta atagctgctg gaggaattgt agatggtaga ggaattgcag
    28501 catcatttgc attaggtgcc agtgcagttc aagtaggaac tagatttatt tgcagtgaag
    28561 agtgttctgt ccattcaaac tataaaaact tagtactaaa agcaaaagat agagatgcaa
    28621 ttgtaacagg aagaagtact ggtcatccag taagaacatt aaaaaataaa ctatcaaaag
    28681 aatttttaaa gatggaacaa aatggagcta ctcctgaaga actggataaa aaaggtacag
    28741 gagctttaag atttgcaaca gtagatggag acatagaaaa aggttcattt atggcaggtc
    28801 aaagtgctgc tatggtaaaa gaaataacac cttgtaagga aattatagag gctatggtaa
    28861 atcaagcaag agagattatg ccagcaatag aactgtaaat caggaggagc aagatgggaa
    28921 aagttgcact agtattccct ggtcaaggag ctcaatatgt aggtatggcc aaggatttat
    28981 atgaaaataa tactgttgct aaaagtgtaa tagatgaggc tagtgatgcc ttaaatatgg
    29041 atttaaaaaa ccttatgttt aatggaaatg aagaagaact ttctaaaact gaaaacactc
    29101 aacctgctat ggttacacat agtgtagctg tattaaaagc agtacaagcc caagtagatt
    29161 taaaatatag tgcatgttta ggtttatctt taggagagta tagtgcattg gttgcagcag
    29221 atgcaattga ctttaaagat gctgtatgct tggtcaaaaa aagaggtaag tttatgcagg
    29281 atacagttcc aacaggtgtt ggagctatgg cagcaatttt aggtctagat agaagtatat
    29341 tagaaaatgt agttaaagat atacaaggag gtattgtgga agtagcaaat tataattctc
    29401 ctggtcaaat agttatatct ggtgaaaatg aaaagataga agaagcaatg gtgaaatgca
    29461 aagaagcagg agcaaaaaga gctgttaaat taaatgtaag tggacctttt cactcatcaa
    29521 tgctaagaga agctggtgta aaattggcca gtgaattaga aaaagttaac ataactaaac
    29581 ctaaagttga tgtggtggca aatgtaaatg cagattacta taaaaacgaa ggtaaagacc
    29641 tgcttataaa acaagtaagt tcatctgttc tttgggaaga ttctatagaa agacttttaa
    29701 atgatggata tgatactttt atagaaatgg gacctggaaa aactttaaaa gcatttatta
    29761 agaaaatagc ttccaataaa aaagcaaatg tcaatattta taatatagat ggtatagatt
    29821 ctcttaatga atttgtacaa aattatagaa atggagagat ataatgataa atcttacagg
    29881 acaagtagca gttgttactg gtggctctag gggtatagga aaagaaatag caaaaaaact
    29941 agcatctttt ggagctgatg tagtaatcaa ttatacttct aaagaagatg aagcactaaa
    30001 aactaaaaat gaaatagaaa gtatgggggt aaagtgtacc tctataaaat gtgatgtgtc
    30061 taaatttgat gaagtgaatc aaatgataga ttctgttgta agcgaatttg gaaaaattga
    30121 tatattggtt aataatgcag gcataactaa agatggtctg cttatgagaa tgaaagaaga
    30181 agattttgat agagttatag atataaactt aaaaggtgtc tttaattgta caaaagcagt
    30241 tactaaacct atgatgaaaa agaagtatgg aagaataata aatatgactt cagtagttgg
    30301 aattatgggt aatgcagggc aaactaatta ttgtgcatca aaagcaggtg taattggatt
    30361 tacaaaagct tctgcaagag agttagcatc aagaaacata aatataaatg cagtagcacc
    30421 tggatttata gaaacagata tgactaaagt actaagtgat gatgtaaaag aatcaacact
    30481 agcaaacata ccaaagaaat cttatggtaa accagaagat gtagccaatg ccgtagcatt
    30541 tttagttagt gacatgtcaa gttatataac aggacaagta ataaatgtag atggtggaat
    30601 ggtaatgcaa taataattta aaaagtagag aaatctatta aaataaaaaa ttttaggagg
    30661 tacacaatgt ttaataaagt tgtagaaata ataatagagc aattaggagt agaagataaa
    30721 gaaataacta tggaaacatc attaatgaag gatttagaag cagattcatt agatgcagta
    30781 gaaataataa tggcacttga agatgaattt ggtatagaaa taccagatac agaagcagaa
    30841 aacttcaaat ctataggaga tatagttaag tatatagaag ctaataaata gtcgagcttt
    30901 aaaaaagtgg aggtatccga tgaataaaag agtagtaata acaggacttg gatgtgttac
    30961 gccgttggga acaggaaaag aagagttctg gagtaatata aaatctggag tatctggtat
    31021 agataaaata actaattttg atgctagcac atatcaaact cagatagcag gagaagttaa
    31081 gaattttcat ccagaagaat atataagtaa aaaagaattg aagagattag ataaatttgc
    31141 tcaatttgca atagtatctg ctaaattagc agttgaagat gcaaatcttg atttagataa
    31201 agttgataga gaacgttttg gtgttataat aggttctgga ataggtggag ttgaagctat
    31261 agaaactcaa cataaaattc ttttggaaaa aggaaataaa agagtaagtt cactttttgt
    31321 acctatgatg ataggaaata tggcagctgg tcaagtttca atatttttag gagcaaaagg
    31381 gcctaacact aatgtatgta cagcttgtgc atcaggaact cattcaatag gtgatgcttt
    31441 taaggtaatt caaagaggtg atgcagacat catggtagca gggggttctg aagctgctgt
    31501 aacaggtctt gcttttgctg gattctgtaa catgaaggct atgtcaacta gaaatgatga
    31561 ccctaaaact gcatcaagac catttgataa agacagagat ggttttgtaa tgggagaagg
    31621 agcaggtatt gttatcttag aagacttaga acatgcttta gcaagaggcg ctaaaatata
    31681 tgcagaagta gttggatatg gtttaactgc tgatgcatac catatgacaa ctccagctga
    31741 aaatggagag ggagcagcta ggtctatgaa tatggctttg aaagatggaa atgttccatt
    31801 agaagaagta gattatataa atgctcatgg aacttcaact tattacaatg atttatatga
    31861 aactatggct ataaaaactg tatttggaga aaaggcatat gacttatgtg tgtcatcaac
    31921 aaaatctatg actggtcact tattaggagc atcaggtgct atagaggctg ttgtttgtgc
    31981 tatgagtata gaagatagtt ttgtgcctcc aactataaac atacaagaag ttggtgaaga
    32041 tttggattta gattatgttc caaatcaagg taaagaaaaa aatattagat atgcactatc
    32101 aaattcttta ggatttggtg ggcataatgc tacaatagta ctaaaaaaat atgtataaat
    32161 aaatattaaa tataaaacta aaaaacaagc acttgtttta actgtataaa tttatattag
    32221 cttaaattta aagtctccta aattatttta ggagactttt ttattaagat ttaagtctag
    32281 catatgttgt aaatcatttt gatatattgt attattaatt attaagaggt tatttatata
    32341 tgtaagtttt cattctacaa tatacaaaag gaggactaaa attttgaatt ttagactacc
    32401 aaagaaaagg ttacccaaaa agataatttt tatatgtata atacttatta gtattatttt
    32461 gtttataaag catgaccaaa atggattgaa agaaagagaa attataaata agggaaaata
    32521 tatgtctgaa agccttgtgg cagataagga gtatgatgaa gcaaaaaaag tggttaagac
    32581 ttctttcgaa tctattccag aaaaaaaata caataaagta tataatgaag tttgggatat
    32641 gttaaagact atttcatatg ttccagatgg aacgaagata gtcattgatt ctttagaaaa
    32701 gatgagagaa tcagatgtga aattatctga tgaatgtaga tttaatatag aaaaaagatt
    32761 agcatcagtg tatataatgg ataataatta ttctaaggca gtagatttaa ctgtaaagtc
    32821 tataaagttg gctgagaaat tggggaataa ttatgaaaaa gcaagactag atgttgattt
    32881 ggcgagcata tttttaaaga taggtggcta tgaaacagga gagaaattaa taaaggattc
    32941 ttttaaaata gatattgatg aaggtgaaaa aaatggaatg gttagattat atgctattat
    33001 aaatctagca gaaatatatg tagaagaggg cgaatatgat aaagctattg aaataagtag
    33061 caggataaaa gattataaaa agtttgtaaa tacggataat tacaatgatt ttgatataat
    33121 ggcctctata atgcagtcaa atgcgtatgt gggcaaaaat aatatacaaa aggcaaagac
    33181 ttttttagaa aaagctgatt atcttataaa atcagataga acagtttata tattagataa
    33241 agatatgtac tattatatgg caatgggaaa cttagaatat aaaagcgaaa attataattc
    33301 tgcaatagat aattataaaa aaagtttaga gatatctact aaaagaaagt taacccagga
    33361 gaaaataaaa aatttaaata agatattaaa tatatatgaa aaacaaggaa atatagaatc
    33421 tttaaatgag tatcaaaaga tgttaataaa tgaatataaa gagaacaaaa gtataagaga
    33481 ttcagagact agtttctata taattgataa agtatcaaac gaaagtaagc tatttgaaaa
    33541 aactaaaaaa gaaataaaat attataaaat attatttaca gtaattttaa ttgctatatt
    33601 agggtctact tttttataca accgattgaa gtattttaaa gcacaaaatt tacatgatgg
    33661 tcttacaaat gtttataata gaaaaagttt tgatattatg tatgaaaagt acagagagaa
    33721 agatgataat tttgcacttg tgatgataga tattgataat ttcaagctca taaatgataa
    33781 ttatggacat aaatttggtg acactgttat aaagggaata acaaatacca tttgtgttat
    33841 gttagaacaa gatgataaag tctttaggta cggaggagaa gaattttctg tattaataag
    33901 aaataaatct ggtgatgaag tagcagatat aattgacagt ataagggttg caattgcaaa
    33961 taaaaagtgg aatgatgatg tgactgtgac tataagtgca ggtgtagctc atgtttcaga
    34021 tagcaaagat gtactagaag aagctgataa aaatttatat aaagcaaaac aacttggtag
    34081 aaataaagta gtatataagt aattatatac tatataaata agaggtataa atatgaaaca
    34141 atcaatagct atagtaactg ataaaataac taaactatca tctttcttag aagaaaatat
    34201 acgtttggtt ttaggtaatt atattgatat aaaccactat tatctggaag ttttaaaaga
    34261 gaatgataaa atacaaggtg attttgtact agtaatgaat gatgatagat taaacagtat
    34321 gagaaagcat ttagtacaag atagtaagat tatagtgata aggagaacac ttaaagaaaa
    34381 tgaaatatat ggattatttt caataccaaa tggaactgaa gtattggttg taaatgatac
    34441 aaaagaaact accttagaaa cgataagctt attttacaaa ataggagtaa aaaatttaaa
    34501 gtttactcca tatattgaag gaaaaattta taaaaatata gacatagcta taacgcctgg
    34561 agtaaaggga aaagtaccaa gttatataaa taaagtaatc gaccttggaa atagatatat
    34621 tgatatatct acctttatag aaataataaa tggtcttaga atagatgtta aagaaatacg
    34681 taaaaattta atggcatatt ctgagagttt aataagttta gataatggag ttaaagataa
    34741 ttataggcaa ctgtttttaa aaatagaaga acaagatgtt atattgaatc tatcaaaaga
    34801 tggaataata tttacttcag cagatggtat aataaacaca tttaataaag aagctttaaa
    34861 aattttaggt ataaatgaaa atccacaagg caaaaacata gaagatatca tttctgaaga
    34921 tttaaatatt ttacttgaag acaaagaaat aattgatgaa gtggtattta caaataaaaa
    34981 atatataaat gtaaataaaa aaagtatttt ttctatgggg aataaagctg ggatatatta
    35041 taacttacaa gaaataacgt atataaaaaa attagaacaa aatcttacta ataaattaag
    35101 agaacaaggt cagatagcaa gatatacatt taaagatata aaaactaaaa ataaaaatat
    35161 ggtaaagtgt gtagaattgg ctaaaaaaat atctaaatca gaactttctg tattaataat
    35221 aggagaaagt ggtactggta aagaattatt atcacaatca attcataatg cttccaatag
    35281 aagtaatcaa ccgtttatag cagttaattg tgcagcagtt ccagatagtc tattagaaag
    35341 tcaactgttt ggatatgaaa aaggctcttt tacaggagct ttaagagaag gaaaaaaggg
    35401 tctatttgaa cttgctaata atggaactat atttctggat gaaattggag atatgcctcc
    35461 attgctacag acaaagttac taagggtatt acaagaaaag caggttatgc ctataggttc
    35521 ccataatgtt ataaacatag atgttagggt catagcagca acaaacaaaa acttactaaa
    35581 gatgattaga gaaggaaaat ttagagagga cctgtattat agactaaatg tattgccaat
    35641 agatgtacca tcattgagga atagaaaaga agatataata acacttatga atttcttttt
    35701 gaaaaacaat ataagacttt cgccagaagt tataactatt ttagaaaaat ataattggcc
    35761 aggaaatata agagagttac aaaatgttgc ttcttatgta agtctaatgt gtgatagtat
    35821 ggtttttaga gatgacttac caccatatat aagggtagaa tgtgctaaca attatgaaga
    35881 tggatttggt tatacaagaa aagaatttga ggaaatactg aggattctat atgaaagaag
    35941 agagtcatcc tctggaattg gaagagggtt tataatcgaa aagcttatac aggaaggtat
    36001 tgagatttct gaaagcaaag ttagaaaggt gctatcttat ttaagtgaat gtggatacat
    36061 atcatctaaa tctggtagag gaggaagtca aataacctca gaggggataa aactttataa
    36121 taatataaat taagctaagt atttgatatt gaaatcacat attttgaatt tagatattta
    36181 aataataata aacttttata tttatagaga ttaatttata ttatgtcaga aagaatattg
    36241 taatttataa ttaaatatta ataggttttt aaaataggat tagataggta ataggttaag
    36301 ttagaataac ccattaccta tttttatttg taagaaaagt gtacatagaa ttagaagtaa
    36361 aaaatacaac taataaaact attgaaaata ctagataaat aataaataaa aataattata
    36421 gattttggca tacatattgc taattataga gataagacga caaaataatt gggaggttta
    36481 atgatgaaat acaaaacaac agggacttgt gctacagaaa ttgaatttga agtaaaagaa
    36541 aataaagtta caaatgtaaa ctttataggt ggatgtgatg gaaatttaaa agggctaaaa
    36601 gtattagttg aaggcatgaa tatagaagat gtaatacaaa agttaaaagg aatagagtgt
    36661 aaaacaaagc caacatcttg cccagaccaa ctgtctctag cattggaaaa ttatatgaat
    36721 ataaagtaat acataaaaca atcgattagt taggagttta attatgaaac caataatagg
    36781 gattttagga aatttaataa taatggaaaa tggtatgttt ccaggtcttg aaaggtcata
    36841 tgtaaataat gattatataa atgcagtgct aaaaggagga ggtagtccag taataattcc
    36901 tgtaaataca gataaagaag ttataaaaaa acagattgaa atggttgatg gagtcttaat
    36961 atctggggga tgggatatca atcctcaact gtatggagaa gaaacaagag aagaaacgac
    37021 atttatatat ccagaagtgg atgaatttga tttaattgca ataagtatag cattagaact
    37081 taaaaagcct atattaggtg tatgtagggg actacaaatt ttaaatgtaa gtttaggagg
    37141 aactttatat caagataata atcttataga aggaagttat ataaaacata cacaatcttc
    37201 taaaagacat gtagctactc ataaagttga tgttaaagaa ggaagtattt tagagggaat
    37261 tttaggaaaa caattactta caaatagtta tcatcatcaa agtgtcaatc agcttggaaa
    37321 aggattaaaa gccatagcat actcaaaaga tggtataata gaagctattg agaaagagga
    37381 tgaaaatttt gtagtaggag tacagtggca tccagaaatg atggtagatt actgtgataa
    37441 aatggaaaaa ctatttaaat attttataaa tatttgttca aatttataat ataccttggg
    37501 gggattgaac atgaacgaaa agaacaaaat gggattaata agtattatac ttttaggtat
    37561 taatgcagta gtaggagctg gagtttttct attaccagga gatgcaatga aatcatttgg
    37621 tgtagcaagt atatttgtat atatatttga tatgttgtta gttttatcta tggcattctg
    37681 ttttgctgag gttgcaggta aattcaataa aaatggtgct gcctatgtat atacaaaaga
    37741 agcttttgga gatttttgtg gttttgaagt aggtcttatg aaatgggtaa taggatgtat
    37801 ttcttgggga gctttaatag taggttttcc tacatcatta tcagcagtat gggctccagc
    37861 aggtgaacca catatacaaa aaattataat tgtagtcatg atagttgggc ttacaattat
    37921 aaacttatta ggtgtatctc tatcaaaaat tgtacaaaat gttataactg taggtaaact
    37981 aattccatta atactattta taggaatagg tatatttttt ataaaaggag ttaattttac
    38041 ttcttcaaca atggtacctc caggagctgg agcaacagag tttggagcag cagcactttt
    38101 aatgttttat tcatttacag gatttgaatc tatagcagtt gcagcagaag atatggagaa
    38161 tccacaaaaa aatataccaa tagcaattat aagtgtaata gtaattgcat caataatata
    38221 tatattaaat caagttgtat gtgttggtat actaggagat tcgttatcta gtacatctac
    38281 accagtggca gatgctgcaa gaatatgctt tggaaatatg ggagctggat tggttacctt
    38341 tggaaccttg gtttctgttg gtggaatttg tatgtgtggt gcttttgtaa atccaagaag
    38401 ctgtgtagct ttagctgatg ataaaatgtt accgagaata tttgcaagaa aagataaaaa
    38461 aggtacacca tatgtagcga taatagctac tatgctaatc actataccaa tagctctatc
    38521 tggaagtttt gctgaattag cagcaataag tgcagttgct agattcatac aatacatacc
    38581 aacatcttta tccgtattag tgtttagaaa gaaaagacca gaattagtag gtacttttaa
    38641 aactcctttt ggagcagtga ttcctctaat tgctgtatgt gttggaacat ggttattatt
    38701 ccaagcatct atgcatcaat taattatggg attaggagct ttggcaattg gagtaccatt
    38761 atactttata atgaagtctt ataatagaaa agtctatgat gaaaatttaa agaaaatagt
    38821 ttaattatgt tataacaatt tattgagtta aaattagaca ttggcataaa attaaataca
    38881 aataagtatc tacaaggcta tattaaaata ttattaattt tttattttaa tatagcctta
    38941 tattgttatc aataaatgaa aaatattgta acaatagaag aacaatagta ttatgtttat
    39001 agacaaaaaa cttattagga ggtaaattta tgccaacaat aacattaaaa aatggtgtag
    39061 acgtacttat tagagaaggt gtaagagaag atgctcaaag cattatagat ttttataatg
    39121 aagtgggtgg agaaactcat tttctgtcat ttggaaagga tgaatataaa atatctttgg
    39181 aggaacaaga aaatgctata gaatcagcaa aagcatccga taattctgtt aaactgattg
    39241 catttataga tggtgaaata gttgggattg caacgattga ttctaatcaa aaagcaaaag
    39301 gaaagcatgt tggagtatta ggaattgttg taaaagaaaa atattgggga attggattgg
    39361 gtaaaaggct tatgttagac cttatagaat ggtgtaaatc aaatggaata accaagaaga
    39421 taactcttgt cactaatgaa gaaaattata atgctatagg attatacaaa aaagttggat
    39481 ttgaagtaga aagcatacta aagaaagaat gttattataa tggtgtttat actgatttaa
    39541 taggaatgtc acttttattg ggaatataat tagtgtacat tttatctcga aaaaagtata
    39601 ttaagtatgg tataattaaa aaagaatata acttaatata attttggagg acgaattatg
    39661 aaaaatctgt gtaaaatatc agatgattat ttaaacagca agcttaagta tttaaagtta
    39721 ttatcaaaac aatatccaag tatatcaaaa gcaagtacag aaataataaa tttagaggct
    39781 atattaaatc ttccaaaggg aacagagcat tttataacag atgtacatgg tgaatatgaa
    39841 ccatttgtac atgtattaaa aaatggttct ggtgtaataa agagaaaaat agaagaattg
    39901 ttttcaaata caataagaga cagcgaaaaa aaaatgttag caactcttgt atattatcct
    39961 gaacaaaagt tagacctaat aattaagcaa gaggaaaata tagatgattt ttatagaata
    40021 aatatttata gacttataga actttgtaaa tatgcttcta gcaaatatac taggtctaaa
    40081 gttagaaaac tgttaccaga aaattttaaa tacataatag aagaactttt gcatgagcat
    40141 gttaaaagtg aacataaaga agagtattat aaaagtatag ttgaaacaat agttgacata
    40201 ggaatagcta aggagtttat aattgctatt tctacagtta tacaaaaatt ggttgtagat
    40261 agacttcatg taataggaga tatttatgat agaggtccaa gaccagatat aattgtcgat
    40321 aagcttattg aacatcattg tgtagatatt caatggggaa atcatgatat attgtggatg
    40381 ggtgcagcct caggtgaaaa aacttgtata gcaaatgcac tgaggatatc agctagatat
    40441 gcgaatttag acattgtaga agacatatat ggaataaatc tattgccttt agccactttt
    40501 gctatagaaa tgtataaaga tgacccttgt aaagaattta ttccaaaggt taatgaccaa
    40561 agtgtaacaa caacagaaaa gtctttaatg gcaaaaatgc acaaagcaat aagtataatt
    40621 caatttaagc ttgaaggtga ggttatcaga cgaagacctg aatttgaaat ggaacataga
    40681 ctcttgctta atatgataaa ctatgatgaa ggtacgatta atttaaaagg taaaacatat
    40741 aaattaaaag atacttattt acctacaata gacaaaaaag acccatataa attaactatg
    40801 gaagaaagaa atgttattga taaattagta tcttcattta gaggtagtga aaaattacaa
    40861 aaacatgttt catttttgtt ttctaaagga agtatatatt taaaggctaa ctcaaattta
    40921 ctgattcatg gatgtgtacc gttaaatgaa gatggaagct ttatgtctat gaatataatg
    40981 ggaaaagagt ataaaggtaa ggctcttatg gataagatgg agtctctagc aagagaagga
    41041 tttttcttta aagataaggc agaagaaaaa ctgtatggca tggatattat gtggtattta
    41101 tggactggga aatgttcatc attatttggt aaagatgata tgactacatt tgaaagatac
    41161 tttatagctg aaaaagagac tcataaagaa aataagaacc catattttaa acttagagaa
    41221 aatgagatgg cttgtaaaag attatttgaa gaatttgatt tagaacttga tgaatctcat
    41281 ataataaatg gtcatgttcc tgtggagagt aaaaatggag agagcccaat aaaagctaat
    41341 ggtaaaattc tcgttataga tggtggtttt tctagggctt accaaaaaac tactggtata
    41401 gctggataca ctttgatata caattctaga actttgcaat tagtatcgca tgaaccattt
    41461 aattctgctg aagaagccat tgcaaatgaa agtgatatct tatcgacaac tgttgtagta
    41521 gagcataagg caaagagaaa aatggtgaga gatactgatg aaggagtaaa gatacaagag
    41581 gaaatagaag atttaaaact acttttaatg gcttataaga aagggctaat aaaagaaatg
    41641 tagatgttat agaggcactt catgattgaa gtgtcttttt gttaatactt attaaatata
    41701 ttataaagat taataatagt agtttatatt atacttacta agtgaatcca agataaatgg
    41761 gttcactttt tttatttata aacattatta aaaaaatata gatgttttgg ttatattcct
    41821 tgtcctttat aaatagaatt atataaacaa aggaggagga caagagatga ataaactttc
    41881 tgatgaaata ataaactctc tttctacaac tataagagaa aaggtagaaa aagtctcaaa
    41941 caataatctg aacatagaag aaattaggtt acgctcacaa aaaccattga tactaaatgc
    42001 aaactctaaa gattattttt acaatcaaaa aactatgaca cttgatttaa atcaacaaaa
    42061 ctcatatgta gtaacaagag aagatgtaga gcaaactttt caaataatat gtaaatattc
    42121 aatacattca tttatggatg acataaaaaa aggattcata actttgagag gaggtcatag
    42181 agtagggtta gttggaaaag caatagtaga agatggacaa gtcaaaaata taaagcatat
    42241 atcatcttta aatataaggg tatcaaggga aattattgga tgctcggata agattttaag
    42301 tcatatcata aagggaaaaa atcagattaa taatactttg ataatatcac cacctcaatg
    42361 tggaaaaaca actttaataa gagatatagt aagaaattta agtaatggta atgaagatta
    42421 tggatttaaa ggtttaaaag tggctttagt agatgagcgt aatgagatag caggagctta
    42481 tctaggtgtt ccacaaatgg atgtgggaat aaggactgat ataatagaaa cttgcccaaa
    42541 agacttgggt attacaatgc ttttaaggtc tatgtcacca aatgttattg tgacagatga
    42601 aattggaagt gaaaaagaaa taaaggcatt atacacagca ttaaatggag gtataggatt
    42661 aataactact gtgcatggag attcaataga ggatatacaa aatagaaaag aattaaatag
    42721 acttctggat aaagagttat ttaaaaaggt tataattctt tctgcaaaaa gaggagcagg
    42781 aacaattgaa aaaatttatg atttagaaga aaagagatgg tattttgcaa attaaaataa
    42841 ttattatagc tttcttgata ggaagtagtt atttgatagg tgaacaaata tacaaaactt
    42901 atactcgtag acataaacaa ttaaacgatt taataagagt tttagaaatt ttgaggatgg
    42961 atttatcttt tggactttat acattagaag aaatctttaa taggataggt ggaaataaag
    43021 agttttgttt ttggaaattt ttctatcaaa tatcagaagg acttcacaat gaacaaagta
    43081 aaactttgga aataataata tcagaaaata ttgatgtctt aagtaaagaa acttatctag
    43141 gcaataaaga aattgaggaa ctgaaaaatc taatacttac tttagggaaa agcgatatag
    43201 agtcacaaca aagaatgata gatttatcta tagaaaattt gaaaaaacaa acctatgaga
    43261 caaaggaaga tataaacaaa aaaggcgtat tgtataaaaa attagtgaca ttcataggta
    43321 taggtatatg tattatattg atttaatatg gggaggttta ttatggaaat atcattgata
    43381 ttaaaggttg caggtgtcgg tattctaata tcagtattga atatgatatt ggaaaaaaca
    43441 gatagaaaag attgggcagg tcttactaca ttagcaggtg taataatcgt attgggtatg
    43501 gtaataacag aaataagtga cttgtttaat actgtaagaa caatgtttca actttactaa
    43561 agaggaggga gtaatttgga aataatgcaa ttaataggaa ttgcaatcat ttcaactaca
    43621 ctctgtttag taattaaaaa agatagacca gagatagcaa atttcatagc tataataact
    43681 ggagtaataa tactattgtc agttatgttt aagctaaatt ttatagtaga tagtatacaa
    43741 gatttggcta acaaggctaa catcccgact atgtatatat cattaataat aaaattaatt
    43801 gggatagcat acttaatgga atttgcgata caactttgta aagattgtgg ggaaggaaac
    43861 attgcttcaa aactagaatt tggaggtaaa ataatagtta tgtcaatgtc tttccctata
    43921 cttttgtcca ttgtagaaat ggtggtgaat ataattccat agatgtgtat cttggaatga
    43981 atataagtat attagagagc ttttgttgta ttgaggttta tagagtgaag agaggcatgg
    44041 ttgcttatga aaaaaagatt tttaccaatg attataggtt ttttatttac tttctttttt
    44101 gtaaatatct ttgctattat gatatttgct aatgaagtac caagtagtga agataaagaa
    44161 tatggtgaaa caaaaaatag catagataag tatatagatg gtcaattaga caagctagat
    44221 ataaatgaga ttcaagacta tataaataaa gaaatagtta ttaatgatgt taatttaaaa
    44281 tcatttgtaa aagatttaat tagtggagaa aaaaatatct tagatttatt caataaagat
    44341 ggattgaaga tattgatgtt tgatgaattt aaagcaagtt taaaggtagt agcagtaatt
    44401 ttggtactgg ctctgttatc atctatttta aagagtctgg aaaactcttt ttcatcaggt
    44461 gcagtaagtc aaatagcaac atatataata tttatcacaa tggtatcact tacacttatt
    44521 ggttttaaag atgtattaca gatttgctat gatgcaatag accatactgt aggtcttatg
    44581 caagttataa tgccaatatt aataacattt ttacttttaa ttggattccc aataacgtcg
    44641 actactttga atcctatctt cataggagga gtaacattta taaatgtatt ttttaaaaat
    44701 tttctatttg tatctattac tgttgcattt ggaattttaa taataaacaa tttatcaaaa
    44761 aatataaggc taaagagatt tttctccttt gtaaaacaaa taaattatgt ttctattgga
    44821 gctatgttta ctgtttactt aggtcttgta tccatacaag gattgtatgt aaccagtttt
    44881 gataaattca gtgtaaagac tgctaaattt gctataggta attttattcc tgttgtaggt
    44941 ggatttgtat ctgactctgt ggatatttta ttatcttcat ctcagcttat aaaaaatata
    45001 tttggaggaa tagggcttat cttacttgtt ggaatttgct tacttccagt aataaaaatt
    45061 ttatcagtaa tagtagtgta caaattagca gcaataattg tagagcctgt tggagaggat
    45121 ggaatatcta attttttaaa tgaagtggca aatttaatga taataatgct agcatcagta
    45181 attgctataa cagtaatgtt ctttgtaact gtagctatct tgacctcgat aagtgtcgta
    45241 agtcaagggt aatttatata tcagtgaaaa ataattacat ttaatctaat gtttttagag
    45301 aggaggatgc tatgttagag ggcataaagg catggatagt tagtgttttg ataggagcat
    45361 ttatagtaaa tatagtagat atgattttac caagttctaa gataaaacct tatgtcaacc
    45421 tagttttaaa ctttatgttt gtatttattg taataactcc agtagtagga tttttttcaa
    45481 aagatatgag tttagaagat agaatattaa aatctatggg aaactacaac aagcagtatg
    45541 tagatagtac aaatgctttg gcaaaagaga ctggaaataa tagtctatcc aagggatatg
    45601 aggatgggtt aaaagaagta cttaaattaa aacttgatga atatggttat gatttagaag
    45661 atatagagct taatggggca aatataaata atataaaaat aaaagaaaag aataatagtg
    45721 caaaaagtaa taacagttcc aatgaagaaa ataaaaataa tagtactaaa agagaggaag
    45781 aaaacataaa ctctaatgac aaagaaaatt ctaaacaagt cttcaaaaaa ggtacagagt
    45841 atgggttgaa cctaaatgaa gaaaaattaa aaaacgactt aataaaggtg ctggatgttt
    45901 ctatagaaga tatacaaatt gataaatagg agttgggaga atgttgaaaa acttaaatga
    45961 caaagataag agaaaggtat attcactaat aactatagca ggaatatgtg tggtttcatt
    46021 agtattatta tcttgttttc ctagtagcaa aagcgataaa caagttggaa aaacagagac
    46081 taataaaaat gctgaaaagc aagtcactaa agaacaagaa aaagatgatt tagagtcaaa
    46141 attaacagca atactatcta aaattgatgg tgcaggagac gttgatgtaa tggttacatt
    46201 tgaatcaagt gaagaaatac aacctgcttt taattcaaat aatacaacag aaacaacaga
    46261 ggaaaaagat gcacaaggtg gagaaagaac agttacgact tctagtgaaa ataaaacaat
    46321 gataacttca aattcaagtg accctgtagt tataaaaact acagagccaa agataaaggg
    46381 agtgatagtg gtagcaagtg gagcaagtga cccaagtgtt aaagagacac tttatagtgc
    46441 agtacaaaca tcattacaag tagctggtca tcaagtagaa atatattcta aataaataca
    46501 tataaccggg gggataaatg aatgaagttt aattataagg gaagaggatt tgtaataata
    46561 actttaactg caatgttagt ggtagtagga acagtgaatt atcaactaag taagaaatct
    46621 ttattagaaa catcaaaaga gtttaaggca tatgaagaag cacagttgca aaaaaatact
    46681 gatgatagtt atagtagtaa gacagaggat tctagtaatg tagataaaca aggtggtaag
    46741 gaaagtgctg atattgatat agtcgatagc aaagctagta aagtaaaaga aaaggcaact
    46801 gagacaagta aggaaataaa agctcaatta tcatcagaga aaaatatgaa aaaggcatct
    46861 tatattttag atatgaaaat gaatagagaa aaacaaagaa atgagttagt tcaagattta
    46921 aatgaaatga taaataatcc atctacaaca gaagaatcta gaaaagaagc ttctaatatg
    46981 aaattaaata tagttaaaat tcaagaaaaa gaacttcaaa tagaaaacct tttgagtaca
    47041 aaaggatatg aagaagcgtt agtttatata agcgataaca aagttaatgt agttgtaaat
    47101 gaagctaaat tagaaaagaa agatgcagca aaaatatttg atttagttgc agaacaagcc
    47161 aatgtgaagt atgaaaatat taaacttaca aataataata gtaataagta aagtataaac
    47221 ctcagaatta actgaggtta ttttcttgca aagtagactt gtatttggta ttattatact
    47281 tataaaaata gttccttaaa atcaggaggt aagttttaat atggaagata ataaatttgg
    47341 acaagtaaaa atatctaatg atgtaatagc tacaatagct ggtttagcag cattagaagt
    47401 tgaaggcata gaaactacag caacattaac agataagttg ttaaaaaata atggagtaaa
    47461 aatacaaatc gaagaagagg atgttaattt agatgtaatg gttacgataa agtatggaat
    47521 gtcaatacca gatacagctt ttaaagttca agaaaatgta aaaaatactg ttgagacaat
    47581 gacaggactg aaggtttctc aagtaaatat acacattcaa ggaatcagct ttaagaagga
    47641 taaagttgat aaagaagaag caaaagcaac taagaaaaat taatattagc cctctgaaaa
    47701 gtcagagggt tttttgctgg taattgattt tatatggata attaaactta aaggagaatt
    47761 ttgattgatg aaaaaagata gggcacaaaa gagtacaaca agagaatata taatgaaact
    47821 tatataccaa ataaatatta ataaagaaga ttttgaaact ttagaagata aagtagataa
    47881 ttttttaaaa gataattcag aacatattat aaatagatat aaagaacttg cacttcaata
    47941 ctcaaaaaat acaaatttaa agttagaaga tactgaaatt gaagatgtta tagacaaaaa
    48001 atatataaat acagtatgca aagcattgaa agaaaatcat gacaaaatag atgagttaat
    48061 aaataagcat gctaaaaact ggacagtaga tagaatgcca aaggtagatg tttctatact
    48121 tagattgtct gtgtgtgaaa tactttattt agacactcct aataaagtat caataaatga
    48181 agcagtagaa cttgcaaaaa tatattgtga tgataagtct cctaaattta taaatggtat
    48241 attgggaagt gttgttgatg aaattgggaa ataatataat aattggaatt gatactagct
    48301 gctatactac ttctatagca gctatctctt tagataagaa agttatattc aatgaaaaaa
    48361 taatgttaga agtaagggat aattcaaaag gtttaaggca aagtgaagct gtatttcaac
    48421 atatcaataa tttagggatt cttagtgata ggataaaatc ttttaaagat aagtttaatg
    48481 tagaaggagt ttgctcatca aaaaaaccga gacctgttga aaactcatat atgcctgtat
    48541 tcaatgtagg tcataatttt ggaaaattat tgtctagtat atatggttgt agattttatg
    48601 agactactca tcaagagaat catattgaag caagtttatt aaatagtaaa ttaaaaaata
    48661 ataataaatt tatttctgtt catatgtctg gtggtactac agagatactt ttaacaagca
    48721 aacaagatag tcatcacaat gtatgtgata ctaatttagg taaaattgcc aaaataagta
    48781 ttaaaaaaga tgataaaagt aagttataca ataattttgg atataatata gatataattg
    48841 gaggaagtaa agatattagc tttggtcaac ttatagatag agtaggaatt aagcttggat
    48901 ataaatttcc ttcaggaaag tatttggatg aaaatgcttt aaattgtaat cttaaaatag
    48961 aaagtggtct gaaaacttct gtaagagatg ggtatatgaa tttatcagga ttagaaaatc
    49021 aggtaaataa gattataaat gataatggag ataatactaa tcaaaaagaa tatatatcta
    49081 aattagtatt agattcagta gttagaaata tgtttaaatc tctagtgtat ttatgtgaaa
    49141 cttataatgt aaatgaagta gtatttgctg gtggagtttc tgcaagtaag tatattctta
    49201 gagaattaag catgaagtta agaaaaaagc atatagaagc ttattttaca gaaccacaat
    49261 attcaactga taatgctgtc gggtgtgcta taataggatt gaataacttt ttaggagaaa
    49321 gagtatgaaa ctaagagctt tagatataag tgaagcaaac tcatatatta aaagaatttt
    49381 aataaacgac ccaatacttt ctaatcttaa agttaaagga gaaatttcta attttaaggt
    49441 tcatagtagt gggaatgtat atttatcact taaagatgaa acatcaaagt taaactgtgt
    49501 aatttttaaa agtaatttta atcgcaattt aaaattagat aatggtgtaa aaattatagc
    49561 taatggatat atatcagtct atgaaagaga tggtgcgtat caattataca ttaatgaaat
    49621 tgaaatagag ggaataggaa atttgcacat agagtttaat agattaaagg aaaaacttaa
    49681 taaagaagga ttatttgacc ctaaatacaa gatacctata cctaaaatgc caaactcaat
    49741 tggcgttata acatctccaa caggtgctgt tataagagat ataataaatg taataaaaag
    49801 aagatatccg aaagttaata taaagcttta tccagtaacg gttcaaggag ataaatcagc
    49861 tgaagaaatc tgtgaagcaa ttagattttt caatcatatg aagaatgttg atacacttat
    49921 agttggtaga ggtgggggtt caatagaaga actttggtct tttaatgatg aaatggtagc
    49981 aagagaggtt tttaattctc aaattccgat aatatcagca gttgggcatg aaacggattt
    50041 tactatttgt gactttgtgt ctgatatgag agccccaacg ccatcagcag cagctgagat
    50101 tgctactcca tcattggatg atataaacta taaacttgga aacataaaaa gtaggatgag
    50161 taagtctctt acaaatcaaa tagagctaga ccaatatagg ttagaaacag tatttaataa
    50221 gataaataac tatttagatt cgtacacaat aaaagataaa gttatacaat tagacaaaat
    50281 atatgataaa ataatttttg gaatagaaaa taatttaaaa ttagaagatg aaaaattagt
    50341 aaaaattgga gcattactcc ataatttaag tccattagct actatggata gaggttatag
    50401 tataactcaa aaaaatggaa aagtaataaa tagtataaaa ggattaaaaa taaaggatag
    50461 tatagatata gtattaaaag atggaaattt agaatgtatg atagataaaa ttgaaaataa
    50521 agagggatag tatgaattta acctacgaag aagcttataa aagattagaa agtattttaa
    50581 gtgaattaga atctaaaaat gctagcttgg atgaatcttt aagcctatat gaagaaggta
    50641 taagccttta taaacattgt aataagcttt tagatgatgc taaattgaaa ataagtaaat
    50701 ttaatcaatt gggaatagaa gaagacttta aaatagagga ggaataaaat tggaatttaa
    50761 acaatgtcta aaagaaaaag caagttttgt agaaaaagta cttaaagaat atatgcctaa
    50821 agaagaaggg tatcaaaaaa ctgttattga agctatgaac tatagcttaa gtgctggagg
    50881 taaaagatta agaccaatac ttacattgga ggcttgtaaa atagttggag gtaatgaaga
    50941 tgaagctatt ccttttgcta ttgcaattga aatgatacat acatattcac taatacatga
    51001 tgatttgcca gctcttgata atgatgattt aagaagagga agaccaacaa atcataaagt
    51061 atatggagaa gctatgggga ttttagcagg agatgctttg ttaaactatg cttttgaagt
    51121 aatgcttgca ggctcaatca ataaagaaaa tccagaaaag tatctaaaag ctataaatga
    51181 aattgccaaa ggtgctggta tatatggaat gataggtggt caagtagtag atgtagaaag
    51241 cgaaaataaa caaattgaaa aagaaaaatt agattatata catatgaata aaactgctgc
    51301 aatgatggta ggctgtatga gagcaggagc tactataggt ggagcaaatt ctgaacaaat
    51361 ggaagaaata actaaatatg caaaaaatat cggattatca ttccagatag tagatgatat
    51421 actagacata gtaggagatg aagctaagtt aggtaaaaag gttggaagtg atatagaaaa
    51481 tcataagtca acatacccat ctcttttagg tttagataaa tctaaagaaa ttgcacataa
    51541 tttgattgat gaagcaaaga aaagtataga aaaattatct gatgatgtag attttttaaa
    51601 gggattggct gaatatataa tagatagaga atactaaaat atacagctaa aatcgaggag
    51661 ggaaaaatgg attttttttc ggagattttt aacaatgggg ctttgggaat aagtctgatt
    51721 gcttgtttct tagcacaatt tataaaaata tttactggta aggaaaaaag aattgagtta
    51781 tcaagaatac ttatttcagg aggtatgcct agttcccata gttcttttgt tacaagttta
    51841 gctacagtgg taggtattga aaaagggttt aattctactg attttgctat aattaccgtg
    51901 cttgccttaa ttataatgta tgatgcagca ggtgttagac gggctgttgg taaacaagct
    51961 actatattaa atcaaatggt ggcagatata cagcatggaa agcatataga gcagaagaaa
    52021 ttaaaagaat taataggtca tacaccacta gaagtttggt ttggagcttt acttggaata
    52081 gtaacagctt taatattgat gtaaattgaa aatttacaga ataaaggtga ggataatatg
    52141 tataaatatt tagataaagt aaattctcca aaggatataa aaaatatgag tatagaagaa
    52201 atggatttac ttgcaaagga tataagaaag ttcttagtaa aatctgtttc aaagacagga
    52261 ggacacttag cttctaatct aggagtggtt gagttaacat tagcacttca taaagtattt
    52321 gatagcccta aagataagat tgtatgggat gtagggcatc aatcttatgt tcataaaata
    52381 gttactggaa gaaaagattg ttttgtatct ttgagacagt ttaatggact aagtggtttt
    52441 ccaaaggaga atgaaagtcc tcatgatatt tttgatacag gacatagcag tacatctatt
    52501 tctatagcta caggtattgc ctgtgctagg gatataaaaa aagaaaacta tagtgttata
    52561 tctgtgatag gagatggttc tataacagga ggtatggcac ttgaagcttt aaatcaatta
    52621 ggatatatag ataccaatat gatagtaatc cttaatgata atgagatgtc catagataaa
    52681 aatgttggag gaatgtctaa atatctgtca agtattataa gaaactcaac agttgagaaa
    52741 atgacagatg aagttgataa aattttaaat gttacacaaa caggtgaaat tttatctaag
    52801 actgcacata gatttaaaga taaactaatg tatagctttt ctcctcagga ctgttcattt
    52861 tttgattcat taggtataag atattatgga cctatagatg gccataatac taaagaacta
    52921 atagatatat tgagaaaagc taaacacaaa aaagggcctg ttcttttaca tgtaattacg
    52981 aaaaaaggaa aagggtacag atttgcagaa gaacaacctg ataaatatca tggagtatca
    53041 aagtttgata taaagacagg tgttacatct gcaaaagtta agtctatgtc aattagtgtt
    53101 ggagaaaaac ttgttgatat ggctaatagt aatgaaaata tagtagcaat aacagctgca
    53161 atgccatctg gtacagggtt aaacctgttt gaaagtgcat atccaaaaag atattatgat
    53221 gttggtatag ctgaacaaca tgcaacagga tttgcagcag gtcttgcaaa aaatggtatg
    53281 aaaccttact ttgctgtgta ctcatcattt ttgcaaaggg catatgacca agttattcat
    53341 gatgtatgca taacaaaaaa gccagttact tttcttatag atagagctgg attagttgga
    53401 aatgatggag aaactcatca tggtatgttt gatttaagtt acttaaattc tattccaaat
    53461 attgtagtaa tggctccaaa agacacaaga gagatggagc ttatgatgga tttgtcatta
    53521 aaattagatt gtccactagc aattagatac ccaagaggaa gtagttatta cctagataag
    53581 ggagagtatg gagagattgt actgggtaaa tatgaggtat tagatgacgg tcaagataca
    53641 gtcatacttt gtattggaag tatggtaaaa catgctttag aggctaaaga aatattatca
    53701 agagaaggaa taaatccgac aatagttaat gctagattct taaagccaat tgatgaaggt
    53761 atgttaaaag cattattaaa aaatcataaa aatgtagtta ctatagagga taatattgta
    53821 actggaggat ttggaagtag aataaataag tttattatag ataatgaata taacgtaaat
    53881 atacttaata tagcaatacc agaagaattt gtaaaacatg gcaatataga tgaattatat
    53941 gactttgtag gattatcgcc aaaaagtatt gctgataaga taaggaaatt agttattgag
    54001 taaaaatcta atgtagatat tgtaaattaa aatttatata aaatatagaa tttatcaatt
    54061 agaataaata tcaagtgtgt tacttcaagc tactttagtt atcattaaag tagcttttaa
    54121 cagaaaggta attgtatgaa aaaaagaata gatttattat tagtagaaca agggtacttt
    54181 gaaagtagag aaagagccaa aaaagcaata atggctggat tggtttttgt tgataatcaa
    54241 aggtgtgata aggctggtac agaagtaaaa gaagattgta gtatagaagt aaaaggaaat
    54301 ccaataccat atgtcagtag aggtggttta aagcttgaaa aagcaatgaa aaactttgat
    54361 ttgactattg atggaaaggt atgtatggat ataggggcat ccacaggtgg ttttacagat
    54421 tgtatgctca aaaatggagc aataaaagta ttttctatag atgttggtta tggtcaactt
    54481 gcatggaaat tgagacaaga tgatagggtt gtgtgtatgg aaagaaccaa tataagaaat
    54541 gtgacaatag aagatacaaa gcagtttgct gattttgcgt caattgatgt gtcttttata
    54601 tcgttaaagt tagtacttcc aaaggcaaag gagttagtac gtcatgatgg ggaagttgtc
    54661 gctttaatta aacctcaatt tgaagcagga agagaaaaag taggtaaaaa aggagtagtt
    54721 agagaaaaat ctacacatat agaagttata aaaatgattt ctgatttctc agtcgaaaat
    54781 ggatttgaga ttttagggtt agatttttct cctattaaag gtcctgaagg taatatagaa
    54841 tatctaattc atttgagaaa tggaaatgaa ggatatgaat ttgatggtga gacatacaat
    54901 aacaaaatag tagaagttgt tgaagcttct cataatttag acaaataggt taaaaggggg
    54961 cttagatttg atcctcgaat tatatatgaa aaattgtgcc ttagttgaag aactaaggtt
    55021 gaatattgat aaaaacttaa atatacttac aggtgaaact ggttcaggaa aatctataat
    55081 aatagatgca cttggacttt gtttaggtga taaatatgat aggtcttttt taagaaaagg
    55141 aacagataag ggacttgttg aggctgtatt tttttcagac aatagatatc ttaaaaaaat
    55201 attagaagaa aatgatataa gtatggaaga tgataattta ttggtaataa ctaggttgat
    55261 atactcagat ggtaagagta ctgctagagt aaatggaagg actgttaaag tgtctcttct
    55321 taaagaaatt gcatctacac ttatagatat acatggtcaa catcaaaatc aagctttgtt
    55381 taataaagat actcatttaa aatttctaga cctttttgga gaaaatgaat tggaagagtt
    55441 taaaattgct tataaaaatg tgtaccataa gtatagtgaa gtaaaaaaag ctttaaattg
    55501 cttgacagaa aataaagatg agatgcaaat tcaacgagaa atagatttat taagatttca
    55561 aataaatgaa attgaagctg caaatctaaa taagaatgaa tatgaagatt tattaaaaca
    55621 aagagaagtt tatagaaata gtgaaaagat atataataat ctaaattcga gttatagcaa
    55681 gttacataat ggtgagtata atgttattga cctaataggt cttgcatcta aggaacttaa
    55741 tgacatatct aaatatgaca gtgttttaag tgaatatagt gatactgtag aaagaatcat
    55801 gtatgagtta caagacatat ctggtgagat aagaaattac aaagataata tagactttga
    55861 accttatgag ctagagcaga ttgagcttag aatcgacgag attaataact taagaagaaa
    55921 atatggagac agtatagatg atatatttga gtattatgga aaaattaaag atagattaga
    55981 tgaaatatta aacagagatg aaagagttga acagttaaga agcaaactga tgaatataga
    56041 agaagattta aaaataaaag ccagtaaatt gactaaagca agaatagaag tagcaactac
    56101 tttagaaaaa atacttcttg atgaattaaa aagcttaaat atgaaaaatg taatgttcaa
    56161 ggttaatttt gaaaaaggtc catttacttt agatggagta gatgatattg aatttatgat
    56221 atcttttaac ttaggagaag atattaagcc tatatataaa gttgcatcag gtggtgagat
    56281 gtccagattt atgttagcgt ttaaaaccat attggctgat atagatgata ttgatacatt
    56341 agtgtttgac gagatagata ctggaataag tgggatagca gcacagatag ttggtgagaa
    56401 attgagtgat atagcaaaga aaaaacagat aatatgtata actcatttac ctcaaattgc
    56461 tgcaaatgca gacactcatt attgtataga gaaagatact tcaaataata ggacgtttac
    56521 caatgttagt aagttaaatg aatctcaacg aaaaaatgaa attgccagac ttatagcagg
    56581 taacaatata acagaaaaaa ctattgaaca tgcaagtgaa attattgagt tggctaaaaa
    56641 atgttagtga aaaacaagca ttttaatagg tgtaaagaat ttttatagaa atgctttaca
    56701 tctatttttt atgatgaaat tattttaaaa tatctagtgc ctatattgaa gaaaagtagg
    56761 tttgaaaatg gaatgaactt tgtataaatt tgtaactttg aaatttctaa atgcttaagt
    56821 ataatattat ttattaaggt agtagtgagg ggaggcataa aatgaataaa aaagatacta
    56881 tgcacttaat ttttataatt gtaattttta ttttattatg gtatattgtg gtagcagtaa
    56941 gtgagattaa taaaaatatt gaaagttgta gtaacaaatt agattatttg tcacaagagc
    57001 ttatgagtac taagtcggat attagtaata ctataaatga agaaatgtca aaaagctata
    57061 taacaaaaag tattgactta aaagtgaaaa aaatcgagaa aaaagaatgt attattgata
    57121 tagatgttca attaagtaaa cttggaaaaa atggaaaagt attttttatg tataaagaag
    57181 atagtgataa atggaatgaa actgagatga caaaacatgg agaattatca tatgcatgtg
    57241 aaattaagat aaatacagga agtgaatatg actataaagt agttacaagt ggagctatat
    57301 ctgaaagttc tgatgtgcaa aaattgacta aatctgatta tatgcctgaa caacccatat
    57361 ttaattctgg gataagagat aatagagaat actttattga aatagtagaa aatagtaatc
    57421 ttttcaatca tgagagtgaa aagtcaaaaa ataaagttta tgataatatt agattagaaa
    57481 aagtagatat tattgtaaat gaaggaaaaa aagacactat atacaaagcc aaattagctg
    57541 aaggcttaga tgatggcaaa actaataatt caaatagaaa tcaagtgaat tatgaagtaa
    57601 gttttcctaa aagggatatt gatgacataa tttatattaa agctaaactt acatacaata
    57661 atggagtaga atatacaaag gatataactg aagatataac tatgggatta caagatttag
    57721 aaaaataaat acatatttaa ataaatattc aaatagattt gttcaataaa atagagtata
    57781 aataaaactg tagtagtttt acttatactc tattaaaaaa ttataatttt aattccatat
    57841 atctagcccc ttcaattgga ttataagtat aaggttctat atcataaaaa ccaaactttt
    57901 cgtataatcc ttgtgcactt ttcatgcttg gaagagtatc taatctcatg tgtgtatatc
    57961 caaatttttt agcttcttca atgatttctt ccaatagtat ttttcctatt tttaatcctc
    58021 taaattgatt tcttacatat aatcttttta attcacatat tttaccttca agttttttta
    58081 aagcaacaca acctgccaaa ttttcatcaa caaatgccaa tatcaatgag cctgaaggtt
    58141 ttttatattt tcctggaagt gtttttaatt cattattaaa gtcttgaaaa cataagtcta
    58201 tatttagaga atttgaatat tcagtaaata gaagttttac gttttcaagg ttttctaaat
    58261 ctttttcttc aacaaattgt aaagttatat tttgagccat tttatccgcc attatataca
    58321 catgtttata taatgacttc acctccttga tatatgtata tttttcttaa tatcaattag
    58381 attttaatac cattactttt tcaccaccat agtcaagctc tccattaaac tcaaatccaa
    58441 aatctttata aagcttaata gccattttat tgtcttcgaa tatactaaga tatagttcat
    58501 cacagttata ttcattttta agatgattta caagaaaatc taatgatgct tttccatatc
    58561 ctttaccttg atattttgaa tcaatcataa atctatcaag ccaaactcta tcatcttcta
    58621 aacgaccata catagcaaat cctattaaag aattttcatc atatattcca acaggtaccc
    58681 aagctgttat aaatttagat tcagcaatag aaagtgcatt gctttctata taatctaact
    58741 gacttttatc tacagacaaa ctaactaaat catgccaatt atttatgtct gcaattctta
    58801 catttaattt caagatatta ccgcccttca aactttttgt tacaatctaa tactatcata
    58861 ttatgtatta aaaatcactt attaagattt taaataaact ttttaaatga ataaattctc
    58921 aggaaaaagg aattataaat acataataat acagcatagg agtagatgga tatatgaaca
    58981 aaataaataa aaatttcaaa aatatttgga taatattagg agctgtatcg atttttacca
    59041 tggttataat ttttaataaa aattgtaatg ttaataaaga gactcaaata gaagctttta
    59101 caattaagaa tcatgataaa aaatttgtat atcctatggg aaatataatt ggagtaaaag
    59161 caaatacaga tggtgtattg gtcttaggat atgaggaaga ggatgtagac tatattggag
    59221 gcatacaaat cggtgataat atagtaaaaa tagataataa aaggataaaa aatagtcaag
    59281 atgtatcaga gattttgaat aagattaaaa aaagtaaagt tgaagtgact tttgagagaa
    59341 aaaataagta taaaacagaa gtaatagaga ctaaaaaaga aaatggcaag tataaacttg
    59401 gattatgggt aagagataaa atatctggaa ttggaactat gactttttac gaccctagta
    59461 tggaaaagtt caaagcaatt ggtcatgcca taaaagattc ggatactaat gaactattaa
    59521 agataaagca aggatatata tataagccag aacaattaaa aatagtaaaa gctagtaatg
    59581 aaaaagtagg taaaataaaa ggagatttta atgacagcaa tttaatgggt aatttctcaa
    59641 ataattcaga gttaggtata agtggtaata ttacagaaaa ccataataaa gagtttaatg
    59701 tagcaaataa agaaaagcaa ttaatagaag ttggaagacc gcaagatgta aaaataggag
    59761 gtgcagtaat tctttttgag gataaaaaca aaaatataac aagctatgat ataaaaatag
    59821 aaagtatagt atatgataaa ggaaattata gagatatggt aataaaagta gtagatgaca
    59881 agttattgga atacacagga ggtatcgtac aggggatgag tggagctcca ataatacaaa
    59941 ataataaaat tattggtgca ataactcatg tttttagaga taatccgaaa aaaggatatg
    60001 gtatttttat agatgaaatg ataaaattgt aggtgaggca ttaaaaaatt ttattatttt
    60061 atcaattatc taggaggaat ataattttgg agtgtcgaat atgctttaga gtagataatt
    60121 aggaagcaat tgtgtaaaaa gtttagtttt ctgtaataag aagatgtttt ttaatggggg
    60181 gatttttagt ggaaaaaatc aaaatagttt tagcagatga caataaggat ttttgtcagg
    60241 tattaaaaga gtatttgtct aatgaagatg atatcgatat attaggcata gctaaggatg
    60301 gaattgaagc attagactta gtaaaaaaga cacaaccgga cttattaata ctagatgtaa
    60361 taatgccaca tctagatgga ttaggtgtaa ttgaaaaatt gaatactatg gatataccta
    60421 aaatgccaaa aataatagta ctatcagcag taggtcaaga taagataact caaagcgcaa
    60481 taaatctagg agcagattac tacatagtaa agccatttga ttttgttgtg tttataaaca
    60541 gaattagaga gctagtttct aatagagtta cacaagttga gccaaaacct agaccagttc
    60601 aagagactca aatgactaga agtgattttg ttaagaatgt aggaaatata gagacagaaa
    60661 tcacaaatat aatacatgaa ataggagtac cagctcatat aaaaggatat ttatatttaa
    60721 gagaagcaat aaaaatggtt attgataatg ttgagctttt aggtgcagta acaaaagagt
    60781 tatatccaag tatagctaaa aaattcaata caacaccaag tagagttgaa agagcaataa
    60841 gacatgcaat agaggttgca tggagtagag gaaaagttga cacaataaat caattatttg
    60901 gatatacggt acacaatact aaaggaaaac caactaattc agaatttata gcaatgattg
    60961 ctgataaatt aagactagaa catagtatgg ttaaataaac aagacataaa aagtaaggct
    61021 ttttaattaa ggcattggct ataaatgcgt attacaagca gcgaaacggt ataaccacta
    61081 gggt
//
LOCUS       DAEPID010000015        60065 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.015, whole genome shotgun sequence.
ACCESSION   DAEPID010000015 DAEPID010000000
VERSION     DAEPID010000015.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 60065)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 60065)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..60065
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.015"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            complement(<1..247)
                     /locus_tag="KR257_001064"
     CDS             complement(<1..247)
                     /locus_tag="KR257_001064"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437519.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cysteine-rich small domain-containing protein"
                     /protein_id="HBH0029783.1"
                     /translation="MGENYKFFNHKDCEFFPCHKTNKPEEFNCLFCYCPLYALGENCG
                     GNFKYTDKGIKDCSSCILPHKKDNYNYIMSKFQDLVKI"
     gene            464..1747
                     /gene="hflX"
                     /locus_tag="KR257_001065"
     CDS             464..1747
                     /gene="hflX"
                     /locus_tag="KR257_001065"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004453679.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GTPase HflX"
                     /protein_id="HBH0029784.1"
                     /translation="MKEIQEKALLVGLNLTTIVKKNDDIDTNESMEELKELTKAAGAE
                     VVGSLIQNKHSVDAAYYIGKGKVEEIRAYSDSLDATLVIFNDELSGAQIRNIENVVGR
                     KVIDRTTLILDIFAQRALSKEGKLQVELAQLKYRLPRLYGMGGEMSRTGAGIGTRGPG
                     EQKLEIDKRHILNKAADIRRELKEVKKNRETQRVKRLKSNIPIVALVGYTNAGKSTLL
                     NELIKTHKDYEQEKEVFVKDMLFATLDVTLRKALLPNKKEFLVVDTVGFVSKLPHDLV
                     EAFKATLEEVQYADLILHVIDATNTSYELQKSTTEGVLKELGVNDKKHILVYNKVDKL
                     ELDIYPKSQEDIVYISAKQGINMDKLLNMIEIALMENTYSVSLMLPYERGDIFSRIKD
                     KYNVENFEYGESGITLDVDLDEEDFNIYREYILEK"
     gene            1755..2432
                     /locus_tag="KR257_001066"
     CDS             1755..2432
                     /locus_tag="KR257_001066"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888586.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HEAT repeat domain-containing protein"
                     /protein_id="HBH0029785.1"
                     /translation="MDINWENIDNLEDYFITYLLYKESKTVSQISKIRNISSTEASEQ
                     LIQAKLKIKEMQKDDFEASKDILDKFLELDKIKRLDFMDSLDDEKMVYFKRKVFKRIL
                     VEKNAEDLIVLIWATGELKDDRFLKLLHQLTNHRHSDIRRITYSAIRKIESPSSREVL
                     QKGLYDKNAQTRQYCAKALSKLGDENSLKILQQLKDKNKNFEKEYVLRAYDKAIKSLE
                     NAKNLKK"
     gene            2518..2961
                     /locus_tag="KR257_001067"
     CDS             2518..2961
                     /locus_tag="KR257_001067"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418457.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NUDIX hydrolase"
                     /protein_id="HBH0029786.1"
                     /translation="MIVRRCAGGVVFYANKVLIVKNDRGEWTLPKGKILGGGLPYESA
                     VQRVKVETGIDAKMIDVAGDTMYEFFSRSRQQEVCNAIMWYVMEACNTDCVLAPEFQE
                     GGFYKVKDALEMLSHHKEQALVEVSYKKFKELKKLVSEGDDVPAN"
     gene            3266..3910
                     /locus_tag="KR257_001068"
     CDS             3266..3910
                     /locus_tag="KR257_001068"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888588.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YigZ family protein"
                     /protein_id="HBH0029787.1"
                     /translation="MSNYRTLHEFGMDEITIEKSVFIGYAKPIKSEEEALEFINEIKK
                     KHKDATHNVWAYTVGKNMNIQRYSDDGEPQGTAGIPTLEVIKKEDLRDVAVVVTRYFG
                     GTKLGAGGLVRAYTKGAKLGLEAGKIIYKVMYQEVKVKIDYTQLGKVQNELMNLGYFI
                     KDTVYEDNVEIVVYSRLEDVEKLSEKMIDITSGTGKIVLGEEFYLSEQNGEILI"
     gene            complement(3996..4373)
                     /locus_tag="KR257_001069"
     CDS             complement(3996..4373)
                     /locus_tag="KR257_001069"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004453676.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sulfite exporter TauE/SafE family protein"
                     /protein_id="HBH0029788.1"
                     /translation="MLFALIGFFAGIIGGMGMGGGTILIPALVLLAGIDTKIAQSVNL
                     LSSIPMTLIALAIHIKNKNVIFKLVIPIAVFGVLGAVFGSLLANYLSSDILKKIFGIF
                     LLLVGLFEVKKGFCAKSDKKPLN"
     gene            complement(4373..4759)
                     /locus_tag="KR257_001070"
     CDS             complement(4373..4759)
                     /locus_tag="KR257_001070"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418463.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sulfite exporter TauE/SafE family protein"
                     /protein_id="HBH0029789.1"
                     /translation="MKKTDDLKKKYFDFNLKNTIIGVFTGFINGVFGSGGGTLLVPIL
                     NDIVKVEEHKSHATALSIIIFLTTASSVLYVSKGTYDVNLTIKVAVGSILGGIIGAKL
                     LNKVTGKFLRISFGIIMIIAALRMVF"
     gene            4938..5693
                     /gene="nadE"
                     /locus_tag="KR257_001071"
     CDS             4938..5693
                     /gene="nadE"
                     /locus_tag="KR257_001071"
                     /EC_number="6.3.1.5"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888593.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NAD(+) synthase"
                     /protein_id="HBH0029790.1"
                     /translation="MSNIKIQIDKTVEWLINKVNEANAKGLIVGVSGGIDSAVVANLI
                     KKAFPENSMGVIMSIKSNPQDREDALKVIEGCDIEYLDLDLIEPQSAILDMVVGNLKD
                     KHLYREEYLKMTDANLRARVRMSTIYTIANNLGYLVVGTDNAAEIHTGYFTKFGDGGV
                     DILPIANLTKGEVYEWAKELGVHEDLINKAPSAGLWEGQTDEDEMGTTYNMIDAVLEG
                     RLDEVPKRDQEIIERLHRLSEHKRKTPAQPPKF"
     gene            5776..6495
                     /locus_tag="KR257_001072"
     CDS             5776..6495
                     /locus_tag="KR257_001072"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418467.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YebC/PmpR family DNA-binding transcriptional
                     regulator"
                     /protein_id="HBH0029791.1"
                     /translation="MGRIGNIINRKGKQDAQRAKIFTKHARAIAVAAKEGGADPEYNA
                     ALKTAIEKAKADNMPNDNIDRAIAKGAGAGAGEDYETIVYEGYGPGGVAVIVETLTDN
                     KNRTAGNVRYYFDKNGGNLGTSGCVSFMFDKKGQILVGLGDGVSEEELMDVALEAGAE
                     DFITEEDGYEIITTPEDFSSVRDELKAKGYEFISADVKMIPQTTTVLTEESHLKMMNK
                     LVDMLEEDDDVQDIYHNWEVE"
     gene            complement(6662..7666)
                     /locus_tag="KR257_001073"
     CDS             complement(6662..7666)
                     /locus_tag="KR257_001073"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437541.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="substrate-binding domain-containing protein"
                     /protein_id="HBH0029792.1"
                     /translation="MATIKDIAKDCGLSSATVSYVLSGKGNERRIPLHTQELILNSAD
                     KLGYKRSTPIKHNNIKIAFYWQDEGFELASTNILQAINHIISLEHLNINIIIRPYKVG
                     HLCDDEYFFANNYYDGIVLTGINADDIEYLVKNKPKIPVVVVNREIPGFSSVSIDNEE
                     TGRIAALHAIQNGKNDIAVVFNPTSFTCMTLRGKSFLKTCKEHGIHLSDSIYYCSNKI
                     DSGYDIAQKMLAKNSLKKVIFCNHDVVALGMMNAFHESGIVIGEDIQIFAASNGPSRL
                     MARSIPPLTVIDLKMEETAERSLRMIIDTVTGRINGIQQQVIYPSIIYRQSSPAQNLL
                     "
     gene            7932..8828
                     /locus_tag="KR257_001074"
     CDS             7932..8828
                     /locus_tag="KR257_001074"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892786.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hydroxymethylglutaryl-CoA lyase"
                     /protein_id="HBH0029793.1"
                     /translation="MSKVNIFEVGPRDGFQNLKEFLETDKKLKIIDGLIASGIKQLEI
                     SSFVSPKAIPQMKDAKEVATYCVEKYPDVKLYALVPNLYGAKVAWECGIRDISYVISL
                     SETHNKKNINRTHEESIDELKKIMNTYPDMNICIGMATVFGCPFEGLPKIEDAIRFAK
                     RLWENGIREMNLADTIGIADPKQVRETISALVEALPECRWQVHIHDTRNMGMVNTLVA
                     IESGITTVQSTLGGLGGCPFAPGASGNTATEDLVYMLERMGYDTGVDFVKLLELSKYQ
                     KSFVNGVYSGHHVNIKSDSCNC"
     gene            8966..10228
                     /locus_tag="KR257_001075"
     CDS             8966..10228
                     /locus_tag="KR257_001075"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888596.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0029794.1"
                     /translation="MDIIALLLFLGVIIIAFVRKNNAGILALAIGVIAVRIFGMDDKE
                     LYGAISNSMFTTLVGITLLFAIVNSTGALKLVAEKIVAASGKRVWLIPIAVFIAGFVV
                     AGVGPGAIPALAIIPAMAVPVAITVGYNPVMLALIGECGLMAGRMTPITPEGQIITTV
                     AEGVGIENVMPTILACQTLSTIVFSIVLFIIFKGYKLKKPINVIDSKQIEKFNIKQII
                     SLISIVVMIAFIIIFDMNVGLAAFAVSAVLIFFNIADEGECIKSIPWSTIVMVLGVGA
                     MMTIVDAAGGIDLMSNALSSLMNSKTATPIMSISAGLMSMVSSALAVVYPTMMPMCVD
                     IAKAVGGVDPLALIAAVGVGGSLAGVSPLSTGGALILAAMGSSKKDFNKEEQNKVFVQ
                     LFIMSAVGLLVIAVVSILSFNAITHLMN"
     gene            10304..11497
                     /locus_tag="KR257_001076"
     CDS             10304..11497
                     /locus_tag="KR257_001076"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888598.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CoA transferase"
                     /protein_id="HBH0029795.1"
                     /translation="MKKGALSNIKVLDLTRVLAGPYCTMMLADFGADVIKIEMPRKGD
                     DTRGFGPFVNGESLYYANINRNKKGITLNLKSEEGKNIFLEMVKHADVVVENYRPGVM
                     EKLGLGYDELAKVNNQIIYGAVSGFGCYGPYSERPGYDIIAQAMGGLMSITGQEGGEP
                     TRVGNAMGDVLGGMNLTIGILTALNARKIIGKGQRVDVSLVDSVVSSLETGIQRYFDS
                     GQPELMGNRYASAYPYDSFKASDGSFVIGCGNDKLFEKLCKKVLFREDLLIDERFKTN
                     LNRCEHYKALKPEIEKWSIKHTIKEAVDLISEAGVPAAPIYNLDCVTTDEHIAKAREM
                     IVDISHPIIGNMKVNGNPVKLMTTKAKIDMPAPSLGESNEEIYNGWLGFDSDKIKDLK
                     ENGVI"
     gene            12126..12920
                     /locus_tag="KR257_001077"
     CDS             12126..12920
                     /locus_tag="KR257_001077"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418469.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="enoyl-CoA hydratase/isomerase family protein"
                     /protein_id="HBH0029796.1"
                     /translation="MESVMENLNNLKVEVKDKVCVITINRPKALNALNSDTLRELSQV
                     IDVVSENEAILGVIITGEGKVFVAGADIRQMQNYKSEEGRKYAGYAQGVFDKIEALEK
                     TVIAAVNGYALGGGCELAMSCDIRIASEKAIFGQPEVNLGVIPCFGGTQRLSRLVGTG
                     IAKELIFTGRQVNAEEAKSIGLINKVVPSDLLLEESMKMMNQIVEKAPIAIRYAKVVI
                     NKGIDMDLKNALELEKDIAGLTFATRDKQEGMNAFIEKRKPVFENK"
     gene            13015..14355
                     /locus_tag="KR257_001078"
     CDS             13015..14355
                     /locus_tag="KR257_001078"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437552.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GntP family permease"
                     /protein_id="HBH0029797.1"
                     /translation="MNTGVIISLVGIIIALSLLVVMVMKGINIFIIAIVCSSLVAITG
                     SLNVYDALKVDYMTGFVGFLQANFFIFLTGTLMGKIMEITGGAKSIAKMIVRWIGKDK
                     ALLSIPIACGILAYGGVSVFVVSFAVFPIALEIFKEADLPRRFIPAALTFGCSTFAMV
                     APGAPQIQNIVPASTLGTDIMAGAVNGFISCAVMFIVGSTILYKMVSKEKANGGHFIA
                     HESDIFDEAEATNSKRENGPNGVIALIPLIVSILIINVKVNGKAIVPIEVGVFIGALL
                     VYLLLNKYQDNTKIVGHVGDACKTTVVAICNTCAVVAFGSVVKSAVGFDFIVNAMTNI
                     PGPPIAGAAVGTTVIAGICGSASGGLGIAAPLLGPVFLAKGVSAAALTRTMAISSAAL
                     DSLPHNGYIVTVTNGLCKETHKDAYMPIFWVTVLTPFIGTIVAVLLFTMFPGLP"
     gene            14492..15724
                     /locus_tag="KR257_001079"
     CDS             14492..15724
                     /locus_tag="KR257_001079"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418473.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CoA transferase"
                     /protein_id="HBH0029798.1"
                     /translation="MLNKPLEGVKVIDLTYFVAGPGTSKILADWGADVIKVEPSFGDP
                     GRKTGATMTMPIDDYNNPFYSTYNSNKRGLSINLKSETGIEIMDKLLSEANVFVSSYR
                     TGALKRLGLDYESLSKKHPHLIWGQINGFGDFGPAKDNAGFDTVAFWARSGAMLDIAE
                     KDTSPINPPIAFGDATTSCSLSGGICAALYQQAKTGKGQKVMASLFGQAIWNASSLLA
                     STQFSDEYPKTRKNAISPVINSYRCKDGKWIFLSILEHERYFEALCRLFGREDLIKEE
                     KFASSVESKKNATELINILDGEFAKFTQNEMVEKLTAADIAHEKIQHVNDVVTDEQAI
                     ANNYIYEHTSKDGNKTMLASTPVKFGNIEVNMTCDAPLIGEHSDEILRELGYSDSDIE
                     ALIESGIVTMNKEACEIC"
     gene            15764..16906
                     /locus_tag="KR257_001080"
     CDS             15764..16906
                     /locus_tag="KR257_001080"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437554.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="acyl-CoA dehydrogenase family protein"
                     /protein_id="HBH0029799.1"
                     /translation="MDFRLTEAQLMLQRVAKEFAENEIAPIAAETDKTGIFPRELFSK
                     MAKIGFNGIGTPVEYSGSGGADIEKVIVVTEIAKKCAASAAILSIHTIYAQAILKFGT
                     EEQKKKYLPMMAEGGCVGAFALTEPNAGSDAARAATTAIIDEETDEYVLNGTKCFISG
                     GGQAESLIIFALTDPSKGIKGMSAIIVDKGTPGFSIGKIEEKMGIHGSETAELIFDNC
                     RVPKSNLLGKEGKGFNIAMTCLDGARIGVGAQAVGIAEGALEESIKYSKERVQFGKPI
                     SALQGIQWYIADMATMVESAKLLVYYAADLKARGEKHTKEAAMAKYNASRTAREVTNL
                     ALQIHGGYGYMKDYPLERMYRDAKITEIYEGTSEIHKVVISRAVLG"
     gene            16917..17711
                     /locus_tag="KR257_001081"
     CDS             16917..17711
                     /locus_tag="KR257_001081"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009899720.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="electron transfer flavoprotein subunit beta/FixA
                     family protein"
                     /protein_id="HBH0029800.1"
                     /translation="MNIVVCLKQVPDTNEVKINKETGTLIRDGVPSIINPDDRNALEE
                     ALKMKDELGAVIKVISMGPPQAKSALKEALAMGADEAYLISDRAFGGSDTWATSTIIA
                     AAIEKVGKYDVIFCGRQAIDGDTAQVGPEVAEFLGIPQVTYAKEVKVQDDKLLVTRYT
                     ETGDYLIEAKMPVLLTAIKELNNPRYPSVKGILEAYNNGDAKITVLTLADLDVDTTQI
                     GLKGSPTNVYKSFVPVKDKHNEIIEGINKKEKAEKLIEILFDLKLV"
     gene            17722..18744
                     /locus_tag="KR257_001082"
     CDS             17722..18744
                     /locus_tag="KR257_001082"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437556.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="electron transfer flavoprotein subunit
                     alpha/FixB family protein"
                     /protein_id="HBH0029801.1"
                     /translation="MMRAKVNQGINLNDYNGVWVIGEQREGKINPVTIELIGEGRKLA
                     DQLGKELAVVIAGYEVEKEVKELLHYSVDKVYYINDPLLKDFTTDGYAISIANLIERK
                     KPEVVLVGATSIGRDIAPRIAGKVGTGLTADCTKLEIDSTDNKLLQTRPAFGGNLMAT
                     IVCPKNRPQMSTVRPGVMAKAVRNESETGILEVVTPELTEKMIRTRLVEILPQEKKSV
                     NLTDARIIVSGGRGLKRAEGFELIKELADKLGAEIGASRAAVDSGWIEHSHQVGQTGT
                     TVRPELYIACGISGAIQHLAGMSDSKYIVAINKDAKAPIFSICDYGIVGDLYEIIPEM
                     IESLNR"
     gene            18843..20219
                     /locus_tag="KR257_001083"
     CDS             18843..20219
                     /locus_tag="KR257_001083"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888607.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sigma-54-dependent Fis family transcriptional
                     regulator"
                     /protein_id="HBH0029802.1"
                     /translation="MKEQWYKDIFARVLSMTDDGFIVVNRSGVIIDINDKYCDFLGKE
                     RKDIIGQNIQSIIPNTKMLDVMKNKYCEEGAIHHYSGGNTKEKSVIVSRSYVENDNGE
                     VVAGVAQVKFRLQSFDVAKKLMSEYMELQYYKEQFKDNCGFDKLIGENRDFIELKKTG
                     VKASKTNFPVLLTGETGTGKEVFARAIHNNSSRSDKPMVSINCAAIPEELLESELFGY
                     DEGAFTGAKKGGKKGKFLVANNGTIFLDEIGDMPLTMQAKLLRVLQESEIEPVGGLKT
                     IKIDVRVISATRKNLSKMVEEGLFREDLYYRLNVINIHMMELKDRQDDILLLANYILN
                     KLNVEYKELKVLSDKVKNCFINYTWPGNIRELQNVIKSAYAVSDDMVIMMCDLPSKMD
                     NISRVAQCNVDSNCSIHEMVENYEKSLIIDVLRKYNWKCSKAAEVMGIHKSLLYKKIK
                     KYEIELNN"
     gene            complement(20551..20895)
                     /locus_tag="KR257_001084"
     CDS             complement(20551..20895)
                     /locus_tag="KR257_001084"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418478.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0029803.1"
                     /translation="MDQIKRLHELQQKSYLTKEEFEELKNNTYIERFELRDECDNSYI
                     YTFYTNDKCNDIKFIKSQFIVTLIKIGFLCECGGVFRQKKIVDEYDYGYNAIYKCDSC
                     GKELDKEVENYD"
     gene            complement(21477..21872)
                     /locus_tag="KR257_001085"
     CDS             complement(21477..21872)
                     /locus_tag="KR257_001085"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009265990.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0029804.1"
                     /translation="MLKEQDIKQYLNEKGSAFKENTSIIGVIFPSKFTYALGPVATAL
                     SMQYYAINFGDSGIAVIGLNNVTGKLENEAFLFVPKEEVTSVKFNKKLMSYELEISTS
                     QGTLAFKVNKTMVGASWHKENLATILKSL"
     gene            complement(21972..22715)
                     /locus_tag="KR257_001086"
     CDS             complement(21972..22715)
                     /locus_tag="KR257_001086"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009587569.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0029805.1"
                     /translation="MRYKKILLGVIASVLCLGLLNSCSGYSHDFNSSEEAQKYILSKL
                     KDKYNEEFIITEVKKYKEEKIGLNWIMAEVSSKENSSQTATVYTRNTGLFEDSYHVYY
                     YFDEIKELATPLFQDKPFIRDYQIEVQGHTATTEWNGKESVEEYLKKREYEIETSIYL
                     NEGKTDEEYAEEISYIMQEIVESDLVFNISVYTNDNNLIFYSLPEQHSQPEVEVILEK
                     MEDVKRQQETKKDFKEWKKQNLNNETNSD"
     gene            complement(22761..23090)
                     /locus_tag="KR257_001087"
     CDS             complement(22761..23090)
                     /locus_tag="KR257_001087"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004221612.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4274 domain-containing protein"
                     /protein_id="HBH0029806.1"
                     /translation="MIYNDLRSKLNEYNWDDGFEIPKQILADSSCDLALALEIFYLSD
                     GYAFLDDSTKTADLKEWGRFITVLYDDILNNKFPKTSTAFEIPLSQVQKYKLQKKDIS
                     KIFLTDL"
     gene            complement(23143..23919)
                     /locus_tag="KR257_001088"
     CDS             complement(23143..23919)
                     /locus_tag="KR257_001088"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009587605.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0029807.1"
                     /translation="MMNGQMFQIASIVATSKKALQLSEPIRFSQLEYENKIEFVFLPQ
                     KKFLRTEKYTASNVSLWFEQIKKNGIQDIKLLCPYSVKDRQFLGFSNTTESSILCFYK
                     SGKVTYFTADWQFDSMQKKWNILYSEHEWTNPPSKKPYFENNINSFRDVLLSIKELAK
                     KIECENFANIFTSAINLLDGCSEYPDEKYGLSLPPIPQQNLQMFEAASISDVFGAMGS
                     WNDSPAYMAHKKGLSEEYETLSSELLKNVRLAILYAINEW"
     gene            complement(24197..24868)
                     /locus_tag="KR257_001089"
     CDS             complement(24197..24868)
                     /locus_tag="KR257_001089"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008393244.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HBH0029808.1"
                     /translation="MEHYEKKISFLGENIQTIRKHRGMKQQELADKIGINMQSLSKIE
                     RGVNYPTFDTLEKIMDVLGVTPNELLSGEWKYIDHTEPYIMDIIKREQDFNVSLDYLS
                     ENEFFDNENEYRFYMETILIRYISNYLSNEVVEIEELMEIKQLIQRQKIERMMKVHKE
                     MRGLDRYREQPKEYKYHNPYDDWIFRQLADIDNRKNIPNTSPQVDFNEGDYEDYLKAK
                     WNRGL"
     gene            25335..26426
                     /locus_tag="KR257_001090"
     CDS             25335..26426
                     /locus_tag="KR257_001090"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018594174.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="replication initiation factor domain-containing
                     protein"
                     /protein_id="HBH0029809.1"
                     /translation="MTTHKNLSVKIDYISIVFDTATAEDVIMHILGLPTDIFNVYPAS
                     IKYKTYQARWQIGDIYVSGDARKTEDNPQGLGCYLVMTGRGCDDIFRILDSRNYTFGD
                     MFRRCERRYGLDNFHFTRLDIAIDDKNEKPFFTIEQIKKKCEKEEFISNSEGYHFDES
                     KFDDFDTAKTVYIGAGKSGLSYRFYDKDKEVCSKHNKTLEEVGSWKRTEMQLRDDKAH
                     AFAMTFKDRPLELGELAFGLLANNLRFVVPNRNESNKSRWKTCRFWERFLGAVEVLKL
                     QVPKQQNSLEETQQWLTEGGVISAVKSFYFLEEHDALGGLEKVGTMLDKARYSNSLSS
                     KLTAHLQRINRTDLIPYIQYDTKHGKGGI"
     gene            26426..26629
                     /locus_tag="KR257_001091"
     CDS             26426..26629
                     /locus_tag="KR257_001091"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006730246.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="excisionase"
                     /protein_id="HBH0029810.1"
                     /translation="MKNNDIPVWEKYTLTIEEASKYFRIGENKLRRLAEENKDAGWLI
                     MNGNRIQIKRRQFEQVIDKLDAI"
     gene            26708..27901
                     /locus_tag="KR257_001092"
     CDS             26708..27901
                     /locus_tag="KR257_001092"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005336078.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="site-specific integrase"
                     /protein_id="HBH0029811.1"
                     /translation="MKEKRRDNKGRILHTGESQRTDGKYLYKYVDAFGNTKYVYAWRL
                     TPTDPTPKGKREKPSLRELEQQIRRDIEDGIDSTGKKMTLCQLYAKQNAQRANVKKST
                     MKQREQLMRLLKEDKLGARSIDTIKPSDAKEWALRMKDKGFSYNTINNHKRSLKASFY
                     IAIQDDCVRKNPFDFKLSEVLENDTKEKVALTEEQEQVLLSFIKTDNVYHKHYDDVLI
                     LLKTGLRISELCGLTVADIDFKNEVVIIDHQLLKSKEQGYYIETPKTKSGIRQVPLSR
                     ETIQAFQRVMKKRPKAEPFVIDGRSNFLFVNHKGKPKVAINYNALFIRMVKKYNKHHK
                     DNPLPHITPHTLRHTFCTRLASKNMNPKDLQYIMGHSNISITMNWYAHASIDTAKSEV
                     QRLIA"
     gene            28210..29220
                     /locus_tag="KR257_001093"
     CDS             28210..29220
                     /locus_tag="KR257_001093"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018112772.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4116 domain-containing protein"
                     /protein_id="HBH0029812.1"
                     /translation="MHEDKNDIFESIDTEDFDNKTEEECLELVRKNGLNLIYIKNQTE
                     EICLEAVRQNCNAIKCVQNQTEKICIEAVKQDWRMLEFVEEPTEEICMLAINQDGTAL
                     KYIENQTEELCLRAVEKNGAALEYVKEQTEEICIEAVRNSEFGLARVKNQTEKICMEA
                     VKHCSYNLKWVENQTEEICMEAVRQNGLDLKFVKNQTETICLRAVRQNGMALEFVKEQ
                     TVGICLKAVRQYGMALKFVKEQTEEICTEAIKQDKRALSFVKGDKEKYKALYDNNEPF
                     AKRYVRNVIEKENRALIKKGEENAKIKIAGKLYDRGMSFEDISDIVEIEISKLKVSLG
                     VF"
     gene            29331..29819
                     /locus_tag="KR257_001094"
     CDS             29331..29819
                     /locus_tag="KR257_001094"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888613.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flavodoxin family protein"
                     /protein_id="HBH0029813.1"
                     /translation="MKITVLYQTRSGNTERVAKLIEEGAKKVDGVDVKLMRLDNIDLD
                     YLNESKAVIFGTPTYLANTTWEVKKWFDEDSKKVNLAGKLGAVFATCDYICGGPDVAI
                     LTIVGHLMVKGMLVYSGGGSLGKPFIHLGHVHSIEGPELQDEKAIIFGERIATKAKEL
                     FA"
     gene            29995..31923
                     /locus_tag="KR257_001095"
     CDS             29995..31923
                     /locus_tag="KR257_001095"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437567.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="EAL domain-containing protein"
                     /protein_id="HBH0029814.1"
                     /translation="MVWHIEYEIFSAIIVIFLMVYFFRSKFIPTLQNKIYCALLIFSF
                     LFIISNILGSFCLNNIDKIPIFITFLLNQIYLLLLPIPAALVSFYVMAIIYQDIRYMK
                     KRLLFLSIPLIICIILSITNPFTHILFGLSKETGYIRGCGYVATFASFFFYAIYSAFL
                     SFKYRKAMHESKIWAIRGFLIVSIVAIILQAIFLQYLLTGTACACSLLLTYLSMQNRG
                     LIIDDLTGVLNRQSFIQELDLNINTEQSGFIITIALDDFKFMNETFGTKNGDIALKEV
                     GKYLIQIHDVNHVYRIGGDIFSIVVNSQLGIEPDDIIRKIEERFKKPWLVEEISFNLA
                     TSIAVVYYPENAETTEDVIVAIDFSIHEAKRSESRRVVYADASISEKIKKKHVIKNCL
                     KEALKNDGFEVYYQPIFSNSRGRFTSAEALLRLEHKELGFIPPDEFIPIAEQTGLINS
                     IGLVVFEKVCRFIASDEFEDLKLDNIAVNLSVVQCMQKNLADDLLYLMNKYNVSPTKF
                     KLEITETVAMGSFNIIKETMERLIDLGVKFALDDFGIAYSGVTNMLSLPFSVIKLDKS
                     LIWSMNEDSRHKLTVETIIALINKLNMKAVAEGVETIKCAEDLIAMECEYLQGYYFSK
                     PVPEDVFKNLLKENTFTS"
     gene            32100..32510
                     /locus_tag="KR257_001096"
     CDS             32100..32510
                     /locus_tag="KR257_001096"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418487.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="universal stress protein"
                     /protein_id="HBH0029815.1"
                     /translation="MNKKKILVPIDGTERSMHSLEFIKGIFKKDEVEVEIMNVKELVF
                     IDGISLAEEIKNSENLGRRILDKAAEIMGEYDVKVHFTFGYPGDEIIRKAKEDNVDFI
                     VMTKSTKKGLTRMIGSVTASVVKQAKCIVMIVPE"
     gene            32532..32834
                     /locus_tag="KR257_001097"
     CDS             32532..32834
                     /locus_tag="KR257_001097"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418488.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIBC"
                     /protein_id="HBH0029816.1"
                     /translation="MNKKIVAVCESERSLNSLKTAANDLGFDLVYEIQENDNIKNELS
                     IYDIEDASIVLFVTSDSIESIEKIDRFIDREFYEVDPKYIIEDAKSIVSEILIDLN"
     gene            complement(33051..33743)
                     /locus_tag="KR257_001098"
     CDS             complement(33051..33743)
                     /locus_tag="KR257_001098"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888618.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="FadR family transcriptional regulator"
                     /protein_id="HBH0029817.1"
                     /translation="MKSLNATEKIIDYIKLNILNGTFKINSKLPSERKIADLFNISRI
                     PVRNAINILCKEGILRAVPYSSPIVEGFKKVDLFDDGEIYKNHNIQEFYVESLRARQL
                     IESEATKLAILNATSKELQKIKYTYLKSIEELDKVSHGLIEECYDADLQFHKEIILAS
                     HNPIFIKYYELIPKTVSSNQYFGFKYRNSLKDMISHHNKIMIAFDSKDSYLGYTSMYN
                     HLEDVIQLFQHD"
     gene            complement(33769..34956)
                     /locus_tag="KR257_001099"
     CDS             complement(33769..34956)
                     /locus_tag="KR257_001099"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009905132.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MFS transporter"
                     /protein_id="HBH0029818.1"
                     /translation="MKKISNQKLLLLSIVTFFWFSQYVYIPFQNPYLSACNVSTNMIG
                     IIIGAYGISQCLLRLPVGVFADSINKHKIFILSGIFFAGLASLIRVFSPGGNGFLIAN
                     ILSGISSSTWISYMVHYTNFFSTEHQQKATSTIILVNNLGMLIGFVMSTLFYEKLGMT
                     ALCIMSVLSSVIGTILALNIKNHNSKKIPEKISIKKYLSICKDKRLVFFSFMALIQQG
                     IQMSTTMSFTTQILKNLGSSSTLIGLSSIFYMVCAVASSGFASTKFCTKYGPKFWIPL
                     VFILVSAYCFLVPTIKNINIIFVLQVLPGISTGILLSYLTSESMKNVPKHQKSTAMGF
                     FQAIYAIGMSVFPMIVGKISEYTSIQYGYFILAIIAILASILSYTYYKKVDLTLNYDI
                     IQS"
     gene            35292..37169
                     /locus_tag="KR257_001100"
     CDS             35292..37169
                     /locus_tag="KR257_001100"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895840.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS glucose transporter subunit IIA"
                     /protein_id="HBH0029819.1"
                     /translation="MDYKNIAQEILLNVGGKENVNEVTHCMTRLRFKVKSASKVNKDK
                     LSKTEGVITVVESMGQIQVVIGNKVKKVYDEVIKIVPQSNNVGKKNESQEKQGIINSI
                     LSAVAGIFTPTIPAIAGVGMIKGILSVLAMYYMNKNGVDIKETQSYIILNAMADSIFY
                     FMPIILGYTAAKVFNANKIISMVLGATLCYPTFTALMAGEESVRFLGLAVTKATYTSS
                     VIPIIIAIWALSYVEKVLEKYIPEVIKIIMVPTLSLVVMLPATLFLFGPIGIYIGNVI
                     NFSYKYIYELSPALCGAFVGGLWCVLVIFGAHRALLPIGISDVAQTGRQNLLAFAGAA
                     NFSQAGAALGVFFKTKNQGLKTISMSATITALFGITEPAIYGANLRLKKPMVCAVICG
                     AFGGAIMGMGGAYGNAFANQGVLTIPVYAEAGALGFLSYLGGCAIAFFGSAISTYLVG
                     FEDLEESSNKENSSIKVETKDGVIDITSPVEGECIELSEVKDDVFASKAMGEGIAVLP
                     TKGVITAPTDCEVASLFPTLHAIGLKLDNGAEMLIHVGINTVELNGKYFTKHVNQGDL
                     VKKGDKLISFDIDKIKKVGYDVTTPVIVNNTFDFGQVVSCKSSYVSTNDNIISLVLAG
                     N"
     gene            37479..38885
                     /locus_tag="KR257_001101"
     CDS             37479..38885
                     /locus_tag="KR257_001101"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860965.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycoside hydrolase family 1 protein"
                     /protein_id="HBH0029820.1"
                     /translation="MNTGFPKDFLWGASSSAFQVEGAWDKDNKGKTVADYNSFKKSHL
                     QADTKVASDFYHNYEEDIELMKELGMKTYRFSISWARIIPDGEGEINQKGLDFYNKII
                     DKLIECDIEPFVTLYHFDLPFKLVEKYNGWESRETVYAFERFAKICFKHFGDRVKYWQ
                     PHNEQNLIVRVEERINIYDETDSWKIDKMRAQMDYNLCLAHALAVNACHEMIKESKIG
                     AAVSSSVTYPLTSKPEDIYAARMNDNFKVYYMLDMHHYGEYPGYYMKYLEKRNIVPHM
                     EDGDKEILKKAKMDFIAVNYYRTNCAEALPEDSQHPFGLREGTVDFSMYGLFKMSMNP
                     NLEASEYGAAIDPSGLRVALNEYWQRYHLPVIITENGLGAKDILEDGKIHDDYRIDYL
                     RSHINACKLAIEDGVEMIGYCPWSFTDLLSSSQGFNKRYGLVYINRTDHEILDLKRIK
                     KDSFYWYKEVIENNGIVK"
     gene            38913..39761
                     /locus_tag="KR257_001102"
     CDS             38913..39761
                     /locus_tag="KR257_001102"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454252.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PRD domain-containing protein"
                     /protein_id="HBH0029821.1"
                     /translation="MYITKVLNNSLLLAKDDNDEEIILMGKGIGHNYKAGSELNEKDI
                     EKIFVLHDENIKKSIIQLATEIDAEYFGIAQMIIAYGIEKYNLKLMNHIYLALTDHIA
                     FAVRRFKEGIMIENHYLFEIKEFNPKEYDIGKYAITVFKEVLGLDLPEEEIGNIAGHF
                     INAQQDNPYSDRNKRSAKIVNAILQIVHYHFSIVYNKESFYYRRFVMHLKAFSQRFLA
                     NEPSREKIDFIYEQVQKNCKEEYECVKKVGAYMYKEYSRELPRQEELYLMIHIHKILG
                     ELCENS"
     gene            40263..40955
                     /locus_tag="KR257_001103"
     CDS             40263..40955
                     /locus_tag="KR257_001103"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003020373.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HBH0029822.1"
                     /translation="MNKVLIIDDDKDLCILLKKSISIEQIEANYCHSGRDGLVELSKQ
                     DYQLVVLDVMMPGMDGFETMEQIRKYSSIPILMLTSKSDNYSKVHGLRAGADDYLTKP
                     FEITEFTARVLSLIRRYTRFNPKNEEPQQLSFKGLLIDLDQHTVTTNGEPMLLPPKEF
                     GVLLYCARHQGKILTKQQIYEAVWGEPYVYDDSNIMAIISRLRKKIELDPSSPIYLQT
                     IKGIGYQFNTEV"
     gene            40952..41887
                     /locus_tag="KR257_001104"
     CDS             40952..41887
                     /locus_tag="KR257_001104"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418502.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HAMP domain-containing histidine kinase"
                     /protein_id="HBH0029823.1"
                     /translation="MKMDEQTIILFLLLLSIGLLFLSIFAFSKLGHIHKRLKDIEEIL
                     ADVQIGDENRKILIKPCDVMAPLVYQLNEIVYDYENKLLSLKKSDKASKQLMTSLSHD
                     VRTPLTTLIGYLDAVHSGIVIEQEREEYLEIARRRAYDLKDYIDVLFDWFRLNSDEFT
                     LSIESVEIAELSRNILKDWIPIFHEKKLNFEIDIPENRLMVNLDPDGYSRVVNNLVQN
                     VLAHSKARQIKITMSEDSRMVLLRVEDDGVGIARENLPHIFERLYKCDKGRSEKGSGL
                     GLSIVSQMVERMGGQVSVESEIGKYTVFTVSLPLI"
     gene            42035..42958
                     /locus_tag="KR257_001105"
     CDS             42035..42958
                     /locus_tag="KR257_001105"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013273760.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBH0029824.1"
                     /translation="MNNLIIETKNLTKQYGAQKSVSNLNIHVQKGRIYGLLGRNGAGK
                     TTTMKMLLGLTKPTTGEIKIFGQDIHNNEKKLLPRIGCLIESPGFYPNLTGTENLKIF
                     ARLRGIPKKNAVESALDVVGLPNNDKKLFSQYSLGMKQRLAIALAIMHDPQLLILDEP
                     INGLDPIGIAEVRTFIRDLCTERGKTILISSHILSEIALLADDIGIIDHGILLEEESL
                     AQLEEKNSKYIHFAVSDAAQAARLLETQLNLKNFKVADNYNIMLYDTDVSVAEINRAF
                     ILNNIEVSESHLCEDTLEDYFKKVTGGEGIA"
     gene            42942..43712
                     /locus_tag="KR257_001106"
     CDS             42942..43712
                     /locus_tag="KR257_001106"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012816056.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBH0029825.1"
                     /translation="MKELLDIISCEFSKLKRLKFILISILGACLFPIPATILIAKDNL
                     PFEQLFKLVVNFGYFLLLPIVLSIVASQLFFIERDNDVLKNLATVPVPKGKLALAKLA
                     VLLFISLFYSVAGLGATIIGGFIVGIVEGVAVKLGMSIAFGIMFFVTVLPVVVLIVYF
                     NRSYIFSIILSFVYAIFNFSISLNIINFEPNNPLLSVLPAPVIMRWWMAFWGDPTGEY
                     TVLRQPYLLSTPACVGILCLITIIAVLLICMIYKKQEN"
     gene            43722..44504
                     /locus_tag="KR257_001107"
     CDS             43722..44504
                     /locus_tag="KR257_001107"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418511.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBH0029826.1"
                     /translation="MLDIITTEFQKIKRYNILWIGVVAVLFSALLAVFQVVSSHGSDP
                     LTYESFANGVIWNNFSLSFPFGITLIGGYLINREYTDQTLKNILTVPISLRKLLVGKL
                     IAVGGITVLLSLFSFLCTFILGLLFCNINISVILVVKSLVQILSVNLYCYVAVLPIIA
                     YFGRKQNAFLTGVGIAFVYGFCGVFVAGRNLTDFYPITAGLGLVGYNNGAGTVYQPLI
                     GAMTLIVILILTTILLVFTPNYDKVMTISKKKGIKHKKYSHK"
     gene            44881..45417
                     /locus_tag="KR257_001108"
     CDS             44881..45417
                     /locus_tag="KR257_001108"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418513.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="rubrerythrin family protein"
                     /protein_id="HBH0029827.1"
                     /translation="MNLKGTKTEKNLMAGFAGESEARNKYTYYASKARKEGYNQIAAI
                     FEETANNEKEHAKLWFKLLHDGMPSTEENLKDAAAGENYEWTDMYAKFAKEAREEGFD
                     KIAYLFEAVGKIEKEHEERYLKLLENLNEGKIFKRDEEVVWQCQNCGHVYVGTEAPEK
                     CPVCDHPKAYFNIKAENY"
     gene            45449..45838
                     /locus_tag="KR257_001109"
     CDS             45449..45838
                     /locus_tag="KR257_001109"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009905140.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcriptional repressor"
                     /protein_id="HBH0029828.1"
                     /translation="MKFSKQRELILNEILNNPVHPTADYLYENLKKDNPNLSLGTVYR
                     NLAQLTEHGFIRKVSIPGYPDRFDGRIDNHYHIICEVCGEVYDLESEVLNNLQELISE
                     ETDIKITSYNISFKGICNNCKRCSQVG"
     gene            45875..46261
                     /locus_tag="KR257_001110"
     CDS             45875..46261
                     /locus_tag="KR257_001110"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004453642.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="desulfoferrodoxin"
                     /protein_id="HBH0029829.1"
                     /translation="MCSEQKFFICETCGNLVGMIQSGGVPIFCCGKPMKELVPNTTDA
                     AVEKHVPVIEVDGNNVTVKVSSTTHPMTKEHHIAWVYLMTEQGGQRKCLAVDGEPVVK
                     FALNDDDKVISAYAYCNLHGLWKAEL"
     gene            46388..47830
                     /locus_tag="KR257_001111"
     CDS             46388..47830
                     /locus_tag="KR257_001111"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418516.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha-hydroxy-acid oxidizing protein"
                     /protein_id="HBH0029830.1"
                     /translation="MSIYKCSVCGYIYDESKNDKTWDELSEDWECPVCTKGRSYFGKI
                     STVYYEEDEKIAEDIVEDESKLNTEKEGDLNYLSTYLRRDDEVEKHMDIIHEMAVTGK
                     SIIEPMRTKLPVISWDDILIMGAQLNPLPLNEHDEVNTTTIIGKKAKKPMIIENPVYI
                     SHMSFGALSKELKIALAKGAAQNKTAMCSGEGGILPEEKEASYKYIFEYVPNKYSVTE
                     ENLKNSDAIEIKIGQGTKPGMGGHLPGEKVTEEIAKVRNKPVGQDVISPSCFEEIQSK
                     EDLKKLVDELREVSEGRPIGVKISAGHIEKDMEFIAYAKPDFVTIDGRGGATGASPKL
                     LKDATSIPTIFALYRARKYIDTHGLDIDLVITGGLRISTDFAKAIAMGADAVAIASSA
                     LMAAACQQYRICGSGKCPVGVATQDEELRKRLHIENSANRVANFLNVSLEELKTFARI
                     SGHKDIHDLSVDDLYTVNSEISNYTNIQHV"
     gene            48127..48942
                     /locus_tag="KR257_001112"
     CDS             48127..48942
                     /locus_tag="KR257_001112"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728724.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MBL fold metallo-hydrolase"
                     /protein_id="HBH0029831.1"
                     /translation="MERLKIQVLVDNNTYIDRYFVGEPAVSYYIEIDGNRILFDSGYS
                     DVFISNAEKLNIDLGNLTHVVFSHGHNDHTRGIQFLENRYDLSTVELISHPNCFIPRK
                     HGEKSIGAPFSAEEIKNIFMYNPKDKPFNLSKNCVFLGEIPSINDFEKRAKIGKCKIG
                     DLWEDDYVLDDSAIVCKTDKGIFIVTGCSHSGICNIVEYAKKVCGDDRVIGILGGFHL
                     FELNNRLDSTIQYLDKEEIRMLYPCHCVSFKVKAKMNEILNINEVGVGLTISI"
     gene            49544..50728
                     /locus_tag="KR257_001113"
     CDS             49544..50728
                     /locus_tag="KR257_001113"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004453637.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0029832.1"
                     /translation="MQKSVKKAKVTGSMLAIFGVASVLFSSHAGGGFATGNQETQYYV
                     QYGWTAPLMAILAMIILTATMREVIIMYNNNNCRNYKDLFCELWRPYPKLEIIWEIYY
                     YLMVLIAVSAVIAGAAAVFQSIGVNYFVAVFIIGVVLLVFTIFGAMLVSKAATAMTIA
                     ILVCTLTIFIVGIKAKVPEITEILSNRTSFTPGYIKPILNTFIYAGFQSVVIPTLAGC
                     SRPLLKNSKEATKAMIISFVMNAIALGLAVTMLMGWYREIIAAGQTTLPTLYVAGQSG
                     NHTIYIIYNVALFLCLMSTGVTTIFGLVNRFEDHKALSFLSSRMKRRVFTACAIMVVS
                     MLISLTGLSNIVKYGYGYCGYLGLFTIVIPFLTLGHYKNKKFAKENPEAKWPAELNEN
                     VN"
     gene            complement(51105..52214)
                     /locus_tag="KR257_001114"
     CDS             complement(51105..52214)
                     /locus_tag="KR257_001114"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888643.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DEAD/DEAH box helicase"
                     /protein_id="HBH0029833.1"
                     /translation="MDFKSLGISENTINILKKSGITTPTPIQKESIKLIKEGKDVIAE
                     AQTGTGKTLAFLLPIFENISLDINDIQVLILSPTRELAIQITEEAMKLKESKDVSILA
                     AYGGKDIGSQIKKLKGNIHMIIATPGRLLDHLNRKTIDLSKLKTFVLDEADQMLLMGF
                     KNEVEAILKETSNKKQTLCFSATINSQVKKLAYRYTKNPVVVSIQKEEITLNNIKQEV
                     VETTDRKKLDALCKVLDEDNPFMAIIFCRTKRRVDNLEEALAIRGYNCQKLHSDIAQS
                     KRERIMKSFRNLDIQYLIATDVASRGLDISGVSHIYNYDLPETPEDYIHRIGRTGRAG
                     EEGYTCAFIDPKNERMLSEIETAIESKISRRIIEL"
     gene            52676..53869
                     /gene="nifV"
                     /locus_tag="KR257_001115"
     CDS             52676..53869
                     /gene="nifV"
                     /locus_tag="KR257_001115"
                     /EC_number="2.3.3.14"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418528.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="homocitrate synthase"
                     /protein_id="HBH0029834.1"
                     /translation="MCVISKDRAKEIKIVDTTLRDGEQTAGVVFANREKIMIAEMLSD
                     LGVDQIEVGIPTMGGDEKNVIKHICSRNLKSDIMAWNRAVIKDVEESISCGVDAVAIS
                     ISVSDIHIENKLRTSRGWVLENMAKTVEFAKKNGLYVSVNGEDASRADIDFLTEFINV
                     GKQAGADRFRYCDTVGVMNPFSIKNAIETLYERTNFDIEMHTHNDFGMATANALAGIA
                     AGANYVGVTVNGLGERAGNAALEEVLMALKCVYKCDLNNIDTRKFRGICEYVAQASGR
                     ILPTWKPVVGDNMFIHESGIHADGALKDPHNYEPFDPSEVNLERKIVIGKHSGRAAVV
                     NKLSEYEMYISPENATKLLNAIRATSIRLKRSLMDKEILQLYCDILAHEKGTTEEEAV
                     RGSYI"
     gene            53894..55819
                     /locus_tag="KR257_001116"
     CDS             53894..55819
                     /locus_tag="KR257_001116"
                     /EC_number="4.2.1.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895860.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aconitate hydratase"
                     /protein_id="HBH0029835.1"
                     /translation="MGDNIVYKIIKKHIVDGEAVAGSSIGIKIDQTLTQDSTGTMTYL
                     QLEAMGIDKVKTKRSVAFVDHNMLQQGFENADDHKYIQTVADKYGVYFSKPGNGICHQ
                     VFLERFSTPGDTLLGSDSHTPTAGGVGMMAIGAGGLDVALAMAGGAYYIKAPKVCKVN
                     LVGKLNNMVSSKDIILEVLRKQTVKGGVGKVYEYGGEGVKSLSVPQRATITNMGAELG
                     ATTSIFPSDEKTLEFFKSQGREEAWIELKPDADAVYDEEITINLDELKPLAAKPHSPD
                     NVDEVENIGKIKIDQVAIGSCTNSSYEDLMKVAQILKGNKVHKDVSLVIAPGSRQVME
                     MIARNGALADIISAGARILENSCGPCIGMGQSPGTDSVSLRTFNRNFYGRSGTLSAQV
                     YLVSPEVAAVSAIKGVLTDPREFDIKFTNLDVNEFLIDDSMIIKPADVGSDVEVVRGP
                     NIKPFPLNTELSQSIGGKVILKTEDNITTDHIMPSNAKLLPFRSNIPYLANYCFNTVD
                     TEFPQRAKDNNGGFIVGGDNYGQGSSREHAALAPLYLGVKGVIVKSFARIHKANLINS
                     GIIPMEFCDEKDYENISLLDNLEIPNILDNLGSGILEVKNTTKGTSFKVKVELSAKEV
                     DVLKAGGKLNYTKNQAN"
     gene            55841..56836
                     /locus_tag="KR257_001117"
     CDS             55841..56836
                     /locus_tag="KR257_001117"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902188.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="isocitrate/isopropylmalate dehydrogenase family
                     protein"
                     /protein_id="HBH0029836.1"
                     /translation="MYKVTLIPGDGIGPEVAKAMKKVVEATGVEIEWEEVNAGEAVIE
                     EYGTPLPEYIIDSIKKNKIAIKGPITTPVGKGFRSVNVTLRQALDLYVNLRPIKSFKG
                     IKSRYEDVDLVVVRENTEDLYAGIEHKIGDYAAESIKIITRSASERIVDFACNYVKDN
                     KRKKVTAIHKANIMKMSDGLFLDVFREVASKHGVEYDDLIVDAAAMNLVLNPENYDVM
                     VMPNLYGDILSDLGAGLVGGLGIIPSANIGKDCAIFEAVHGSAPQIAGQNKANPTALI
                     QSSVMMLRYLGEYENAQKIETALEKVFLEGSKLTVDLGGSASTTEFADEVCKYIV"
     gene            57162..57635
                     /locus_tag="KR257_001118"
     CDS             57162..57635
                     /locus_tag="KR257_001118"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012816057.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MarR family transcriptional regulator"
                     /protein_id="HBH0029837.1"
                     /translation="MVVSVEVCLIKTLDSNILREVGTLSRAVNSINDIKYKELKLQKG
                     QFTFLTRICENPGINLVELSNMLKVDKATTTKAIQKLIKAGYVDKKQDKFDKRGYNLT
                     PTDKSLEVYELIIEEENRSIEICFDNFTDEEKQVVTKLLEKMSKNVENEWFKVKR"
     gene            57669..58163
                     /locus_tag="KR257_001119"
     CDS             57669..58163
                     /locus_tag="KR257_001119"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004453626.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HBH0029838.1"
                     /translation="MIRKANMNDLESIMQIIKSTVEEMKTYNNTQWDENYPLEKDFVS
                     DIKKQDLYIYEVDGEVAGFICLNYEEPEEYLGLNWSSNKKAMVIHRMAVNPNFRKTGI
                     ASKLVDFAEKLAVENNVSYLKSDTYSINSKMNLLLTKCGFIKIGEMSFLGKEKSFYCY
                     DKIL"
     gene            58260..58781
                     /locus_tag="KR257_001120"
     CDS             58260..58781
                     /locus_tag="KR257_001120"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895862.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nitroreductase family protein"
                     /protein_id="HBH0029839.1"
                     /translation="MIGFLKKRRSIRKYKDVEVEKEKLDKILKAALLAPSSKGLRTWE
                     FIVVDDKEKLINLSQCRTKGGGFFLKNAPLAIVIIADKEKNDVWIEDASIAASYIQLQ
                     AHELGLGSCWIQVRNRMHDDNIEADKYIREELKVPSKYSVECIISIGYPDEEKKAYGD
                     SDLDYKKVHFNNF"
     gene            58970..59281
                     /locus_tag="KR257_001121"
     CDS             58970..59281
                     /locus_tag="KR257_001121"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004453624.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA-binding protein"
                     /protein_id="HBH0029840.1"
                     /translation="MGIFKTKMDEDWKVNYIKEFNEMRDSYESKLQKKQFEVDSLKSE
                     LDRLRSYKNSLKPKEKQITDDDINNIKSLRRDGLSYKEISNQTSWSKATVSRVLNGLY
                     D"
     gene            59309..59995
                     /locus_tag="KR257_001122"
     CDS             59309..59995
                     /locus_tag="KR257_001122"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895864.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CPBP family intramembrane metalloprotease"
                     /protein_id="HBH0029841.1"
                     /translation="MKYSYKKCIIDSILLMFIVQILRMILNYVLLSQFEFTLENFNII
                     NLISFTLVGLSLILFLKDNSLYNKVRNRKITEAFEENKNNILIEKCKLILFVVVLSLA
                     IIVTYCTKGYVLFNVTMMTLSVLIVPIFEELFFREYIWNYLSNFIKSKSKIICITSIL
                     SGIYNIGYIDVIRNYVILYNNSSYTFEVIISKIMIGTVFGIVLGLVKYRFRDVGFCIL
                     LRSLFAIFIR"
BASE COUNT        22173 a         7417 c        11095 g        19380 t
ORIGIN      
        1 tgattttaac taaatcttga aatttactca taatgtaatt gtaattatct tttttatgag
       61 gtaatataca actactgcaa tctttgatac ctttatctgt atacttaaag tttccaccac
      121 agttttctcc taaagcatac aaaggacaat agcaaaatag acagttaaac tcttctggtt
      181 tattagtttt atgacaaggg aaaaattcgc aatctttgtg attaaaaaac ttataatttt
      241 cgcccatatt ttcctcctaa ttaaataaaa tttaaatttt ttatactata taagattttg
      301 gtgataatat aattatacta aataatttta tgaatagtcg ataatatagt attattaatc
      361 atagtattaa tggtataatt agtcaacaga aaaataatgt aaaaataatg taagtgtatt
      421 ttgtaattag aatatgtttt ataacaaaaa atgaggtgat taagtgaaag aaattcaaga
      481 aaaagcactt cttgtaggtc tgaatttgac tacaatagtg aaaaaaaatg atgatataga
      541 cactaatgaa tctatggaag aattaaaaga actaacaaaa gctgctgggg cagaagttgt
      601 aggtagctta attcaaaata aacactctgt agatgcagct tattatatag gaaaaggtaa
      661 agtagaagaa ataagagcct atagtgactc tttagatgct actttagtaa tttttaatga
      721 tgaattatct ggtgctcaaa tcagaaatat agagaatgtt gttggaagaa aagtaataga
      781 tagaactact ttaattttag atatatttgc tcaaagggca cttagcaaag aaggtaaatt
      841 acaagttgaa ttagcacaat taaagtatag attgccacga ctttatggaa tgggtggtga
      901 gatgagtaga acaggtgcag ggattggtac tagaggtcct ggagaacaaa aactagaaat
      961 agataagaga catatactta ataaagcagc agatataaga cgtgaactta aagaagtaaa
     1021 aaagaataga gagacacaga gagttaagcg tttaaagtca aatataccga ttgtagcact
     1081 tgttgggtat acaaatgcag gaaaatctac cctgttgaac gaattaataa agacacacaa
     1141 ggattatgaa caagaaaaag aagtttttgt aaaagatatg ctttttgcaa ctttagatgt
     1201 aaccttgaga aaggctcttt tgccgaataa aaaagaattt ttagtagtag atactgttgg
     1261 atttgtaagt aaacttcccc atgatttagt agaagcgttt aaggcaacat tggaagaagt
     1321 acagtatgca gatttaatct tacatgtaat tgatgcaaca aatactagtt atgaattgca
     1381 aaaaagtacg actgaaggtg tattaaaaga acttggtgta aatgataaaa aacatatact
     1441 tgtatataat aaagtggaca agctagaatt ggatatatat cctaaaagtc aagaagatat
     1501 tgtgtatatt tctgcaaaac aaggcataaa tatggataag ttattaaata tgatagaaat
     1561 tgctttaatg gaaaatactt attcagtaag tttgatgtta ccttatgaga gaggtgatat
     1621 atttagtaga ataaaagata aatataatgt ggagaatttt gagtatgggg aaagtggtat
     1681 aacgctagat gtagatttag atgaagaaga ttttaatatc tatagagagt acatactaga
     1741 aaaataggtt gaatatggat ataaactggg aaaatataga taatcttgaa gattatttta
     1801 taacctatct tctttataaa gaatctaaaa cagtatctca aattagtaaa attagaaata
     1861 tttcaagtac tgaagcaagt gagcaactta tacaagcaaa gttaaaaata aaggaaatgc
     1921 aaaaagatga ttttgaggca tctaaggata ttttggataa atttctagaa ctagataaaa
     1981 ttaagagact tgattttatg gatagcttag atgacgaaaa aatggtatac tttaagagaa
     2041 aggttttcaa aagaatcctt gtagaaaaaa atgctgaaga tttaattgtt ttaatttggg
     2101 cgacaggtga gctaaaagat gataggtttt tgaaattgct tcatcagctc acaaaccaca
     2161 gacactcaga tattagaaga ataacttatt cagcaatcag aaagattgaa tcaccaagta
     2221 gtagagaagt actgcaaaaa ggtctctacg acaaaaatgc acagactagg cagtactgtg
     2281 caaaagctct ttcaaaattg ggagatgaaa acagtttaaa gattttacag cagttgaaag
     2341 acaagaataa gaattttgaa aaagaatatg tgcttagagc ttatgacaaa gccattaagt
     2401 cattggaaaa tgcaaaaaat ttgaaaaagt aattttttat taaagcaatt tgtttactta
     2461 atgatgtatt tctaaagttt aacaaggtaa taaataaatt aatgggaggg gtttcaaatg
     2521 atagtaagac gttgtgcagg tggagtagtg ttttatgcta ataaagtact tattgtaaaa
     2581 aatgataggg gtgaatggac acttccaaaa ggaaagatac taggaggggg acttccatat
     2641 gagagtgctg ttcaaagagt taaagtagaa actggcatag atgctaaaat gatagatgtg
     2701 gctggcgata ctatgtatga atttttctca agaagtagac aacaagaagt ttgtaatgca
     2761 ataatgtggt atgttatgga agcttgtaac actgattgtg tacttgctcc tgaatttcaa
     2821 gaaggtggat tttataaagt aaaggatgct ttagaaatgt tatcacatca taaagagcaa
     2881 gctttagtag aagtatctta taaaaagttt aaggaattaa agaaattagt ttcagagggc
     2941 gatgatgttc cagcaaatta attgtgaatt tagaggattc tgaggaaggg atagcccctt
     3001 ccttttttaa ttgaagcagt tttaagcgta aattatatag tctctttaaa ctatgattta
     3061 tcaatttaga gatttagtag tttatattta aaatcagtaa gatatattta aaataaaaat
     3121 taaaaagtat acaattttat tatataattg tcttatgatg ttgattaaag aattattaaa
     3181 agtccattta tttttaaata gaataatttt ataaatatat atttgatgtg tatattagaa
     3241 aatgattaaa ataggaggaa atacaatgag caattacagg acattacatg aatttggaat
     3301 ggatgaaata acgattgaaa agtctgtttt tattggatat gctaagccta taaagagtga
     3361 agaagaagca ttagagttta taaatgaaat aaagaaaaag cataaagatg caactcacaa
     3421 tgtgtgggct tatactgtag gtaaaaatat gaatatacaa agatatagtg atgatggaga
     3481 accacaagga acagctggga tacctacatt agaggttata aaaaaagaag atttgagaga
     3541 tgtagcggtt gttgttacta ggtattttgg aggaacaaaa ttaggtgcag gtggtctagt
     3601 tagagcttat acaaaaggtg ctaaactggg acttgaagca ggtaagataa tttataaggt
     3661 aatgtatcaa gaagttaagg ttaagataga ttatactcaa cttggaaaag tgcaaaatga
     3721 gttaatgaat ttggggtatt ttataaaaga tactgtatat gaggataatg ttgaaatagt
     3781 agtatattca agattagaag atgtagagaa attatcagaa aaaatgattg atataacaag
     3841 tggaacagga aaaatagttt taggagagga attttatttg tctgaacaaa atggagaaat
     3901 tttaatataa tctaaaaggt tattagaata gttaatacct caaatagcca attagtattt
     3961 ttaagtgaaa agccattaaa ttgatttaat ctaaatcaat ttaatggctt tttatcggat
     4021 tttgcacaga atcctttttt tacttcaaat aaaccgacta aaagtaaaaa tatcccaaat
     4081 atttttttta atatatctga agacagataa ttagctaata gtgaaccaaa tacagctcct
     4141 aaaaccccaa acacagctat aggtataacc aatttaaaaa ttacattttt attttttata
     4201 tgtatagcaa gtgctataag tgtcataggg atagatgaaa gtaaatttac gctttgtgct
     4261 attttagtgt ctatgccagc aagtaaaacg agtgcaggta taaggattgt tcctccaccc
     4321 attcccattc ctccaataat tcctgcaaaa aatccaatta gagcaaataa cattaaaaca
     4381 ccatccttaa tgctgcaatt atcataatta ttccaaaaga aattctaaga aactttccag
     4441 taaccttatt tagtaattta gctcctataa taccaccaag aatacttcca actgcaactt
     4501 taattgttaa gttaacatca taagtacctt tagatacata taaaacagaa cttgctgtcg
     4561 ttaagaatat tattatagaa agagcagttg catgagattt atgttcttct accttaacga
     4621 tgtcatttaa tattggaact aaaagagtac ctcctccaga accaaaaact ccatttataa
     4681 atcctgtaaa aactccaatt atcgtatttt ttaagttaaa atcaaagtat tttttcttta
     4741 aatcatcagt ttttttcata aaaatcacct tctgaaatag ttttaccaaa ataggcaaat
     4801 tatatttata taaaataaga ttaaatataa tctttcatgt ttgtttaatt ttgcataaaa
     4861 aaaaacatat taaaacaaca tattaatata tggtataata tattaaaaca aagtagcaaa
     4921 tttgagagga gataacaatg tcaaatataa aaatacaaat agacaaaact gtagaatggc
     4981 ttataaataa ggttaatgag gcaaatgcaa aaggattaat tgttggtgta tctggaggaa
     5041 ttgattcggc agtagttgct aatttaatta aaaaggcatt tccagaaaac tctatgggag
     5101 ttataatgag cataaaaagt aatcctcaag atagagaaga tgcacttaag gttatagagg
     5161 gatgtgatat agaatacctt gatttagacc ttatagaacc acaaagtgct atattagaca
     5221 tggtagtagg aaatttaaaa gataaacatt tatatagaga agaatattta aagatgacag
     5281 atgcaaactt aagagcaaga gtaagaatga gtacaattta tacaattgct aacaatctag
     5341 gatatctggt tgttggtaca gacaatgctg cagaaataca cacaggatat tttactaaat
     5401 ttggtgatgg tggagttgat attttaccta ttgcaaattt aactaaagga gaggtgtatg
     5461 aatgggcaaa agagcttggt gttcatgaag atttaataaa caaagctcct tcagcaggtc
     5521 tttgggaagg tcaaacagat gaagatgaaa tgggaactac ttacaatatg atagatgctg
     5581 tgttagaagg tagattggat gaagttccta aaagagacca agagataatt gaaagacttc
     5641 atagattaag tgaacacaag agaaaaacgc ctgcacaacc tcctaagttc taatttacta
     5701 tttataagat ttgtgataaa atttacaagt gatgaaaatt agaataatta attgtacgta
     5761 ttaaggagtg gaaatatggg acgtataggt aatataatta atagaaaagg taaacaagat
     5821 gctcaaagag caaagatatt tactaaacat gctagagcaa tagcagttgc agctaaggaa
     5881 ggtggagcag acccagagta caatgcagcg ttaaaaacag ctatagaaaa agctaaggca
     5941 gataatatgc caaatgataa tatagataga gctatcgcta aaggtgctgg agcaggtgct
     6001 ggagaagact atgaaactat agtttatgaa ggatatggac ctggtggagt tgctgttata
     6061 gtagaaactt taactgacaa caaaaacaga actgctggta acgtaagata ctattttgac
     6121 aaaaacggag gaaacttagg aactagtgga tgtgtgtctt ttatgtttga taaaaaagga
     6181 caaatattag ttggtttagg agatggagtt tcagaagaag aattgatgga tgttgcatta
     6241 gaagcaggag ctgaagattt cataacagaa gaagatggtt atgaaataat aactacacca
     6301 gaagattttt ctagtgttcg tgatgagtta aaagctaaag gatatgagtt tatatctgct
     6361 gatgtgaaga tgatacctca aactacaact gtattgactg aagaatctca tttaaaaatg
     6421 atgaataaat tagttgatat gcttgaagaa gatgatgatg ttcaagatat atatcataac
     6481 tgggaagtag aataaatagt ataagcatat tgaaatttat aagtattgaa tcaattttaa
     6541 catgtgataa attttataga ataagaaaca ctaaaataga catacgcacc tctaacctat
     6601 atttgcataa taatatgtaa gcataggtaa ggggtgtttt tatatttata ggttaagaaa
     6661 tttaaagtaa attttgagct ggactcgatt gtctataaat aattgatggg tatataactt
     6721 gttgctgaat accatttata cgcccagtta ctgtatcaat aatcatccta agactacgtt
     6781 ctgctgtctc ttccattttt aaatctataa ctgtcaaagg aggaatactt cttgccatta
     6841 gtcgtgaagg tccattactt gctgcaaata tttgaatatc ctctccaatt acaattcccg
     6901 attcatgaaa tgcattcatc ataccaagag ctaccacatc atgattacaa aaaattactt
     6961 tttttagtga attttttgca agcatttttt gagcaatatc atatccacta tctattttat
     7021 tagaacaata atatatagaa tctgatagat gtattccatg ttctttacat gtttttaaaa
     7081 aagatttacc ccttaaagtc atacatgtaa aggaagttgg gttgaataca acagcaatat
     7141 catttttacc attttgaata gcatgtaaag ctgctatacg accagtttcc tcattatcaa
     7201 tagatacact tgaaaaacca ggtatttcac gatttacaac aactacagga attttaggtt
     7261 tattttttac tagatattct atatcatcag cattgatacc tgttaaaaca attccatcat
     7321 aataattatt tgcaaaaaag tattcatcat cacatagatg accaactttg taaggtcgta
     7381 tgatgatatt tatgtttaaa tgttctaaag aaattatgtg gtttattgct tgaagtatat
     7441 tggttgatgc caactcaaat ccctcatcct gccaataaaa agctatttta atattattat
     7501 gtttaatagg agtagagcgt ttatatccaa gcttatcagc tgaatttaat ataagctctt
     7561 gtgtatgtag cggaatcctg cgttcatttc ctttaccact taagacgtac gagacagttg
     7621 ctgaagaaag accacagtct tttgcaatat ctttgattgt tgccatgata aaatcctcct
     7681 taaatagttg cttaaatttg cttataccaa taatcttaac atatattcaa ctaaagaaca
     7741 atattctaca aggtgcatat tttacagaat tagaataaat aaatttaaaa aaacttctta
     7801 cttatgttga cataatttag tttataggat tataatatgc ttaaataagc ttattattaa
     7861 cttaaattaa gcaaagttaa gcaggaacat gcaatgctag cttgcaatgt gactgtaaag
     7921 ggggaaaagg tatgagtaag gtaaatatat ttgaagttgg tcctagagat ggatttcaaa
     7981 acctgaaaga gtttttagaa actgataaaa agcttaagat tattgatggt cttattgctt
     8041 cagggattaa acaacttgaa attagttcat ttgtaagccc aaaagcaata cctcagatga
     8101 aagatgcaaa agaagtagca acttattgtg tagaaaaata tcctgatgtg aaactttatg
     8161 cattagttcc aaatttatac ggtgctaaag ttgcatggga gtgtggtata agagatatat
     8221 cctatgttat atctttgagt gaaactcata ataaaaaaaa tataaatcgt acccatgaag
     8281 agtctattga tgagcttaaa aaaataatga atacttatcc agacatgaat atatgtattg
     8341 gaatggctac tgtatttgga tgtccttttg aaggtttacc aaaaattgaa gatgccataa
     8401 gatttgctaa acgcctttgg gaaaacggta tcagggagat gaatctagca gatacaatag
     8461 ggattgctga ccctaagcaa gtaagagaaa ctattagtgc attagttgaa gctttaccag
     8521 agtgcagatg gcaggtacat attcatgata ctagaaatat gggaatggtt aatactcttg
     8581 tggctattga atctggaatt actactgttc agtctacact tggaggatta ggaggatgcc
     8641 catttgctcc tggagcatct ggcaatactg caactgaaga tttagtatat atgcttgaac
     8701 gtatggggta tgatacagga gttgattttg ttaaacttct tgaattatca aagtatcaga
     8761 agagttttgt aaatggagta tatagtggtc atcatgtaaa tataaagtct gatagttgta
     8821 attgttagtt ctattgatta atcgattaaa aaaatatgtt gattaaaaaa atatgctgat
     8881 tggtaaaata gatttattga taaaaaatat aaattataaa atacattatc taataaaaca
     8941 aataaaaaaa ttgaggggga ttagtatgga tattatagct ttacttttat ttttaggagt
     9001 tattattatt gcatttgtac gtaagaataa tgcaggtatt ttggctctag ctattggtgt
     9061 catagctgtt agaatttttg gaatggatga taaagaactt tatggagcta taagcaactc
     9121 aatgtttact acacttgttg gtataacact actctttgca atagtgaact caacaggagc
     9181 attaaagctt gttgcagaaa aaattgtagc tgcttctggt aaacgtgttt ggcttatacc
     9241 tatagcagtt tttatagcag gatttgttgt tgctggtgtt ggacctgggg caattccagc
     9301 acttgcaatt atcccagcaa tggctgttcc tgtagccata acggttggtt ataatcctgt
     9361 aatgcttgca cttataggtg aatgtggatt aatggcaggt cgtatgactc ctattactcc
     9421 agaaggtcaa attataacaa ccgttgcaga aggggttgga attgaaaatg ttatgcctac
     9481 tatcttagcc tgtcaaactc tttctacaat tgtattttca atagtattgt ttataatttt
     9541 caaaggatat aaacttaaaa aacctataaa tgttatagat agtaagcaaa tagaaaaatt
     9601 caatataaag cagataattt ctctaataag catagtagtt atgattgctt ttatcataat
     9661 ttttgatatg aatgttgggc ttgcagcttt tgcagtttca gctgtactta tttttttcaa
     9721 tattgctgat gaaggagaat gtatcaaatc aattccatgg agcacgatag taatggttct
     9781 tggagtaggt gcaatgatga caatcgtaga tgcagcagga ggtattgact tgatgagtaa
     9841 tgcattatca tcactgatga atagtaaaac agctactcca attatgagta tttcagcagg
     9901 acttatgtct atggttagtt ctgctttagc agtagtttat ccaactatga tgcctatgtg
     9961 tgttgatata gctaaggcag ttggaggagt agacccacta gcacttattg ctgcagttgg
    10021 tgttggaggt tctcttgctg gtgtaagccc actttctact ggtggggcat tgattttagc
    10081 agctatgggt tcaagtaaga aagactttaa taaggaagaa caaaataagg tttttgtaca
    10141 gcttttcatt atgagtgcag ttggcttatt ggttattgca gtagtatcaa tattatcatt
    10201 taatgcaata acacatttaa tgaactaatt agaataactg aaaataaatc attaaattta
    10261 acttttaata ttaatcaata taatataatt tggaggggaa gttatgaaaa aaggagcatt
    10321 aagcaatata aaggtacttg accttacaag agttcttgca ggtccatatt gtacaatgat
    10381 gttggcggat tttggagctg atgttataaa aatagagatg ccaagaaaag gtgatgatac
    10441 aagaggtttt ggaccttttg taaatggaga gagtttatac tatgcaaata taaatagaaa
    10501 taaaaaaggt atcactctaa accttaaatc agaagaagga aaaaatatat ttttagaaat
    10561 ggtaaaacat gctgatgttg tagtagaaaa ttacagacca ggtgtaatgg aaaagttagg
    10621 tctgggttat gatgagttgg ctaaagttaa caatcaaata atttatggag ctgtatcagg
    10681 atttggatgt tatggaccat attcagaacg tccaggttat gatattattg cacaggcaat
    10741 gggtggtctt atgagtataa cagggcaaga aggaggagaa ccaacgagag ttggtaatgc
    10801 tatgggtgat gtactaggtg gaatgaattt aactattggt atactcacag cactcaacgc
    10861 tagaaaaata ataggaaaag gacaaagagt agatgtttcc ctcgttgatt ctgttgtatc
    10921 gtctctcgaa actggtatac agagatactt tgattcagga caacctgaac ttatgggtaa
    10981 tagatatgct tcagcctatc cttatgactc ttttaaggca agtgatggaa gttttgtaat
    11041 aggctgtggt aatgacaaac tttttgaaaa gttatgtaaa aaagttcttt ttagagaaga
    11101 ccttttaata gatgagagat ttaaaacaaa tcttaatcgt tgtgaacatt acaaggctct
    11161 taaaccagaa atagaaaaat ggtctattaa gcatacaata aaagaagcag ttgacttaat
    11221 atcagaggct ggagttcctg ctgctcctat ctataatctt gattgtgtta caacagatga
    11281 acatatagca aaagcaagag aaatgattgt agatattagt catcctatta taggaaatat
    11341 gaaagtcaat ggaaatccag ttaagttgat gacaacaaaa gctaaaattg atatgccagc
    11401 accatctcta ggggaaagta acgaggagat ttataatggt tggcttggtt ttgatagtga
    11461 taaaataaaa gatttaaaag aaaatggagt tatttgatta aaaaatagct aaacacactt
    11521 gtgactttag tcaggggagg ttcagttaga ataatatcaa aaaatattaa atcaatactg
    11581 taaatcaaat atagaattgt cagaagcatt taagatggga aaagctactt agacattgag
    11641 tctttgtggc ttttcctatt ttcattaaga attttatatt atcagaatag atatgtacta
    11701 aactaaagta ttaacaattt aaattaatag aaaataaact acctaattat gttgaataaa
    11761 gactacttta gtgaaaataa acttatagag atgctattta aattatttta atggaaatat
    11821 caaaaatgag actgcattct caaaaatgag actgcgtttt ttaagtattt tctcgaaaat
    11881 gagacaaaaa tattgtttta tgggttttat tgaagaaaaa ttcttctgtg aattacaatt
    11941 taatcaattt taaagttgaa aattattaaa aatttagtga aatttatgta tatttcgttt
    12001 attttattaa aaataacaat tttttactaa aaataaagaa cttcaatggt gattggcata
    12061 gtacttgcta ttttatatta acaagaaatg tagaaaaaat aacaatgtat aatgggggga
    12121 atatgatgga atctgtaatg gaaaatttga acaatcttaa ggtggaggtt aaggacaaag
    12181 tctgtgttat tactataaat agacctaaag ctttaaatgc tcttaatagt gacactctta
    12241 gggaactatc acaagttatt gatgtagtat cagaaaatga ggcaatatta ggagttatta
    12301 ttactggaga aggtaaagtt tttgtagccg gtgctgatat acgccagatg caaaactata
    12361 aaagtgagga aggcagaaaa tatgcaggtt atgctcaggg agtttttgat aaaattgaag
    12421 ctcttgaaaa aacagtaata gcagcagtta atggatatgc attaggtggt ggatgtgaac
    12481 ttgctatgag ttgtgatatt agaattgcat cagaaaaggc tatatttgga caacctgaag
    12541 ttaatttagg agttattcca tgttttggtg gaactcaaag attatcaaga cttgttggaa
    12601 ctggaatagc taaagagtta atttttacag ggagacaagt aaatgcagaa gaagctaaat
    12661 ctattgggct tattaataaa gtggttccaa gtgatttact tttagaagag tctatgaaga
    12721 tgatgaacca aatagttgaa aaagcgccaa tagcaataag atatgcaaaa gttgttatta
    12781 acaaagggat agatatggat ttaaagaatg ctcttgaact agagaaagat attgcaggtt
    12841 taacttttgc tacaagagat aagcaagaag gaatgaatgc atttatagaa aagagaaagc
    12901 cagtttttga aaataagtag ctattataac taaaattgga acaatgtaga atatattcaa
    12961 aatctaaatt tcgtgaaaaa atacatatag tttaatttta aaaggagtta atttatgaat
    13021 acgggagtaa ttataagttt agtagggatt atcatagctc tatctcttct agttgtaatg
    13081 gttatgaagg gaataaatat ttttattata gcaattgtat gttcatcatt agttgctata
    13141 acaggaagcc taaatgtgta tgatgcactt aaagtggatt atatgacagg gtttgttgga
    13201 tttcttcagg caaatttctt tattttccta acagggacat taatgggaaa aataatggag
    13261 attactggtg gagcaaaatc tattgctaag atgattgtaa gatggattgg gaaggataaa
    13321 gcactacttt ctattccaat agcttgtgga atattagcct atggtggagt aagtgttttc
    13381 gttgtaagtt ttgcagtgtt tccgatagct ttagaaattt ttaaagaagc tgatttgcca
    13441 cgaagattta taccagcagc tttgactttt ggatgctcaa cttttgctat ggttgcacca
    13501 ggggcaccac aaattcagaa tattgttcca gcatcaacat tagggacaga tattatggct
    13561 ggagcagtaa atggttttat atcatgtgca gtaatgttta tagttggaag tacaattttg
    13621 tacaaaatgg tttcaaaaga aaaagccaat ggtggtcatt ttatagcaca tgaatcagat
    13681 atatttgatg aagcagaagc aactaattct aagagagaaa atggtcccaa tggtgtaatt
    13741 gccttaattc cattgatagt gtcaatttta ataattaatg taaaagttaa tggaaaagcg
    13801 atagtaccaa ttgaggtggg agtatttatt ggagctttat tagtatattt attgttaaat
    13861 aaatatcaag ataatactaa aatagttgga catgttggtg atgcatgtaa aactacagta
    13921 gtagcaatat gtaatacttg tgctgtagtt gcatttggtt cagtagtaaa atcagcagtt
    13981 ggttttgact tcatagttaa tgctatgact aatattcctg gtcctcctat tgcaggggct
    14041 gcagttggaa ctacagttat tgcaggtatt tgtgggtcag cttcaggtgg actaggaatt
    14101 gcagctccac ttcttggacc agtattttta gccaagggtg tttccgctgc agcattaact
    14161 aggactatgg caatttcatc agcagcatta gattcacttc cacacaatgg atatattgtt
    14221 actgtaacaa atggtctttg taaagaaaca cataaggatg cctatatgcc aatattctgg
    14281 gtaactgttt taaccccatt tattggaacc atagtagcag tcctactgtt tacaatgttc
    14341 ccgggattgc cataagagaa aagataaaag gtataaatta tattttgatg ttataaaatc
    14401 aattttcaaa atatatacaa taaatttcat gttttaatac tgtaaatatg tatttaaaat
    14461 aacaaattga ccatataagg aggaattgaa agtgttaaat aaaccattag agggagttaa
    14521 ggttattgac ctaacgtatt ttgtagcagg tccagggact tctaaaatat tagctgactg
    14581 gggtgctgac gttattaagg tagagccaag ctttggagac ccaggaagaa agacaggggc
    14641 aacaatgaca atgccaatag atgattataa taatcctttt tacagcacat ataattcaaa
    14701 taaaagaggt ttgtctataa atcttaagag tgaaactgga attgaaatta tggataagct
    14761 tttaagcgaa gcaaacgtat ttgtttcaag ttatagaaca ggagcattaa aaagactagg
    14821 tcttgattat gaatcattaa gtaaaaagca tccacacctt atctggggtc agataaatgg
    14881 ttttggcgat tttggacctg ctaaggataa tgcaggattt gatacagttg ccttttgggc
    14941 aagaagtggg gctatgcttg atatagcaga aaaagataca agtccaataa atccacctat
    15001 agcctttgga gatgcaacaa cttcttgtag tttatctgga ggaatatgtg cagctttgta
    15061 ccagcaagct aagactggaa aaggacaaaa agtaatggca tctttatttg ggcaagcaat
    15121 atggaatgca tcatctttat tagcatctac acagtttagt gatgagtatc caaaaactag
    15181 aaaaaatgct atttcaccag taataaattc ttatcgttgt aaggatggaa agtggatatt
    15241 cttaagtatt ttagagcatg aaagatattt tgaggcactt tgtagattat ttggaagaga
    15301 agacttaata aaagaagaga aatttgcatc ttcagtagaa agtaagaaaa atgctacaga
    15361 acttattaat attttagatg gtgaatttgc aaagtttact caaaatgaga tggttgaaaa
    15421 acttactgct gctgatatag ctcatgaaaa aattcaacat gttaatgatg tagtgactga
    15481 tgaacaggct attgctaata actatatata tgaacataca agtaaagatg gaaataagac
    15541 aatgcttgca tctactccag ttaaatttgg aaatattgaa gttaacatga cttgtgatgc
    15601 tccacttata ggagaacatt cagatgagat attgagagaa cttggataca gtgattctga
    15661 tatagaggct ctaattgaat ctggaattgt aacaatgaat aaagaagcat gtgaaatatg
    15721 ttaataaaca tgtgaagtat gttaataaat aggagggaat tttatggatt ttagattaac
    15781 agaagcacaa ttaatgcttc aaagagtagc aaaagaattt gcagagaatg aaatagcacc
    15841 aatagctgct gaaacagata aaacaggtat ttttccaagg gagcttttta gcaaaatggc
    15901 taaaatagga tttaatggaa ttggaacacc tgtagagtat agtggttctg gtggggcaga
    15961 tatagaaaag gtaattgttg ttactgagat tgccaaaaaa tgtgcagcat ctgcagcaat
    16021 attatcaata cacacaatat atgctcaagc tattttgaaa tttggtactg aggaacaaaa
    16081 gaaaaaatac cttccaatga tggctgaagg tgggtgtgta ggtgcttttg ccttaaccga
    16141 acctaatgct ggttcagatg ctgcgagagc tgcaacaact gcaattattg atgaagaaac
    16201 tgatgaatat gttttaaatg gaactaagtg ttttatttct ggtggaggtc aagcagaatc
    16261 attaataata tttgcattga cagacccatc aaagggaata aagggaatgt ctgctatcat
    16321 tgtcgacaaa ggtacgccag gtttttcaat aggaaaaatt gaagaaaaaa tgggtattca
    16381 tggttcagaa actgcagagt taatatttga taactgtaga gttccaaagt ctaacttatt
    16441 aggaaaagaa ggtaaaggat ttaatatagc tatgacttgt ttagatggag caagaattgg
    16501 agttggagct caagctgtag gaattgctga aggggcttta gaagaaagta tcaaatattc
    16561 taaagaaaga gtccagtttg gcaagccaat ttcagctttg caaggtattc aatggtatat
    16621 agcagatatg gcgacaatgg tggaatcagc aaaattatta gtatattatg ctgcagattt
    16681 gaaagctaga ggagaaaaac acactaaaga agctgctatg gcaaaataca atgcgtcacg
    16741 tactgcaaga gaggttacaa atttagccct tcaaatccat ggtggatatg gatatatgaa
    16801 ggattatcca ttagagagaa tgtacagaga tgccaaaata acagaaattt acgaaggtac
    16861 ttcagaaata cacaaagttg ttatttcaag agcagtacta ggataggagg aaaagaatga
    16921 atatagttgt ttgcttaaag caagttccag atactaatga agttaaaata aataaagaga
    16981 caggtactct aataagagat ggtgtaccaa gtataatcaa tccagatgat agaaatgctt
    17041 tagaagaagc tctaaaaatg aaagatgaac taggagcagt gattaaggtt ataagcatgg
    17101 gacctcctca agctaaaagt gctttaaaag aagctttggc aatgggagct gatgaagctt
    17161 atttaatctc agatagagct tttggtggtt cagatacttg ggctacatct acaattattg
    17221 ctgctgctat agagaaggtt ggaaagtatg atgtaatatt ctgcggaaga caagctatag
    17281 atggagatac agctcaggtt ggaccagagg ttgcagaatt tttagggata ccacaagtta
    17341 cttatgcgaa agaagtaaag gttcaagatg acaaattact agtaactcgt tatacagaga
    17401 caggggatta tttaatagaa gcaaagatgc cagttttatt aactgctata aaagagttaa
    17461 acaatccaag atatccaagt gtcaagggaa tcttagaagc ttataataat ggagatgcaa
    17521 agattactgt attaacactt gcagatttag atgttgatac aactcaaatt ggattaaagg
    17581 gttcacctac aaacgtttat aagtcttttg taccagttaa agacaagcat aatgaaataa
    17641 tagaaggtat aaataaaaaa gaaaaagctg agaaactaat agaaatacta ttcgatttga
    17701 aactagtata ggagtgttaa gatgatgaga gcaaaagtta atcaaggtat aaatttaaat
    17761 gattataatg gtgtttgggt aataggagag caaagggaag gtaaaattaa tcctgttacg
    17821 atagaactta ttggtgaagg aagaaagctt gctgaccaat taggaaaaga gcttgcagtt
    17881 gtgatagctg gatatgaagt agagaaagaa gtgaaggaat tacttcacta tagtgttgat
    17941 aaagtatatt acatcaatga ccctcttctt aaagatttca ctactgatgg atatgcaatt
    18001 tcaattgcaa atttaatcga aagaaaaaag ccagaggttg tattggttgg tgctacttct
    18061 ataggaagag atatagcgcc tagaattgca ggtaaggttg gaacaggtct aactgctgac
    18121 tgtacaaaac ttgaaataga ttcaacagat aataagttat tacaaacaag accagcattt
    18181 ggtggaaatt taatggccac tattgtttgt ccaaaaaata gaccacagat gtcaacagtt
    18241 cgtccaggag ttatggcaaa agctgtaaga aacgaatcag agactggaat tttagaagtt
    18301 gttactccag aacttactga aaaaatgatt agaactagat tagtagagat acttccacaa
    18361 gaaaagaaat ctgtaaatct aactgatgct agaataatag tatcaggagg aagaggatta
    18421 aaaagagcag aaggatttga gcttataaaa gaattggctg ataaattggg ggcagagatt
    18481 ggtgcttcaa gagcagcagt agattcaggg tggatagaac attctcatca agtgggacaa
    18541 acaggaacta ctgttagacc agaactatac attgcatgtg gaatatctgg agcaatacaa
    18601 catttagcag gtatgagtga ttctaaatat atagttgcta taaataaaga tgcaaaagcc
    18661 cctattttta gtatatgtga ctatggaata gtaggagatt tatatgaaat tatacctgaa
    18721 atgatagaat cattaaatag gtaactttta gaaaacattg aatatgtaga atgataagtc
    18781 ttataatatt gtattgtaag acttattatt tttgctgaag gttatagtgg ggagatgaaa
    18841 caatgaaaga gcagtggtat aaggatatat ttgcaagagt attatctatg actgatgatg
    18901 gttttattgt tgtaaataga agtggagtaa taatagatat taatgataaa tattgtgact
    18961 ttttaggaaa agaaagaaaa gatataatag gacaaaatat acaaagtatt ataccaaata
    19021 caaaaatgct agatgttatg aaaaataagt attgtgaaga aggagctata catcattatt
    19081 caggtggaaa tacaaaagaa aaaagtgtaa tagtaagtag gtcttatgtg gaaaatgaca
    19141 atggagaagt agttgcagga gtagctcaag ttaaatttag attgcaatca tttgatgtag
    19201 ctaaaaagtt aatgtcagaa tatatggagc tccaatatta taaagagcag tttaaggata
    19261 actgtggttt tgacaagctc ataggtgaaa atagagactt catagaactt aagaaaacag
    19321 gtgtgaaagc ttctaaaaca aactttccag tacttttaac gggtgaaaca ggtacaggaa
    19381 aagaagtctt tgctagagca attcacaata atagcagtag gtcagataaa cctatggtta
    19441 gtataaactg cgctgcaata ccagaagaat tattagagtc agagctattt ggctatgacg
    19501 aaggagcttt tacaggagca aaaaagggtg gtaaaaaagg taaattttta gttgcgaata
    19561 atggtacaat ctttttagac gagataggtg acatgccttt gaccatgcaa gcaaaacttt
    19621 taagagttct tcaggaaagt gagatagaac cagtgggagg tcttaaaact ataaagatag
    19681 atgtaagagt aatctctgcc acaagaaaga atttaagtaa aatggttgaa gagggattat
    19741 ttagagaaga cctatactat agattaaatg taataaacat tcatatgatg gaattgaagg
    19801 acaggcaaga tgatatttta ttgctagcaa attatatatt aaacaaatta aatgttgaat
    19861 acaaggaatt gaaggtttta agtgataagg ttaaaaattg ttttattaac tatacttggc
    19921 cgggaaatat aagagaacta caaaatgtaa taaaaagtgc ctatgctgta agtgatgata
    19981 tggtcattat gatgtgtgac cttccatcta agatggataa tatcagcaga gtagctcaat
    20041 gtaatgtgga tagcaattgt tcaattcatg aaatggttga gaattatgaa aagagcttaa
    20101 ttattgatgt gttaaggaag tataattgga aatgttctaa ggcagcagag gttatgggaa
    20161 tacacaagag tcttttatat aagaaaataa aaaagtatga aattgaatta aataattaag
    20221 ataaattgaa ttaaggcaat gctaaaaaaa cgcccttatt caaagcgaac tgtataaact
    20281 gttttatgca gttaaaacgt gtaaaagtag atgtgaagta ctaatgtcaa tcattagtac
    20341 ttttttatta tatttataat tactatctat atttcagtat cttttgatat ctaagattat
    20401 tatgtttaat ttaggatata acaaaaccct cttagttatg gacagttttt tatattttaa
    20461 ctgtctacta agaggggata gtttagttta aatttagagt aaattttatc tagcatttat
    20521 aaaaaatatt ttgaatagct tttttgttat ttaatcataa ttttctactt ctttatcaag
    20581 ttctttgcca caagaatcac acttatatat agcattgtat ccgtaatcat attcatcaac
    20641 tattttcttt tgtctaaata caccaccaca ctcacatagg aaaccaattt ttataagtgt
    20701 aacgataaat tgtgatttta taaattttat atcattacat ttatcgttag tgtaaaatgt
    20761 ataaatataa gagttatcgc actcatctct taattcaaat ctttcaatat atgtgttatt
    20821 ttttaattcc tcaaattctt ctttagttaa atatgatttt tgttgcaatt catgtaaacg
    20881 cttaatttgg tccattattt atatcctccc aataatttta gtattttaag cttagataag
    20941 gaatctaagt tttattaaat ttatcccaag gaattattta aatcatattt agttttatta
    21001 attacaacat atataaatta cacgaaaata aaactaattg taaaaataat atcctgtgaa
    21061 aacctaaact actaacccct tactaacccg aaaactaaaa aaagaaaata tatccaaata
    21121 taagtgatat ataaataaag atgtttcata taaatttaac tttaaatatt ctgacaataa
    21181 tatatataaa tatattatag ttaaaatata ccacatattt tgggtattgt atactggaat
    21241 tattgtcaaa ttttatatct aattttagat tatctgcata aacactatac ttttaagcat
    21301 tttgaaatat aagaaaacac tcattttacc acgaatttac cacgattgaa tgagccttga
    21361 tatgacctat aaagtaacac cagaaagaca tcattatacc taaatggtgt ctttttaaaa
    21421 agcagtcaat cataagacta actgctttgt gtgtacagat ataaattttt gaaaacttat
    21481 aaactcttta aaattgttgc taaattttct ttatgccatg aagcaccaac cattgttttg
    21541 ttcactttaa aagctaatgt tccttgtgat gtactaattt ctaattcata agacattaac
    21601 tttttattga atttaacact tgttacttct tcttttggta cgaaaaggaa tgcttcattt
    21661 tctaatttgc ctgttacatt atttaaaccg ataacagcaa taccgctatc gccaaaattt
    21721 attgcgtaat attgcattga aagagcagtt gcaactggac cgagagcata tgtaaactta
    21781 ctagggaaga taacaccaat aatagatgta ttctccttaa aggcactacc tttctcgtta
    21841 aggtattgtt taatgtcttg ttcttttagc attttaattg tcctcctata aaattatttt
    21901 tcgcataact tactgttttc attttatcat ttcaatatag tgattacaat gtatttcgtg
    21961 aaattacaac atcaatcaga atttgtttca ttgttcagat tttgtttttt ccattcctta
    22021 aaatcttttt ttgtttcttg ttgtctttta acatcttcca ttttttccaa aatcacttct
    22081 acctctggtt gactgtgctg ttcgggtaga gaatagaaaa taaggttatt atcgtttgta
    22141 tatactgaaa tattaaaaac caaatcactt tctacaattt cttgcatgat ataggaaatt
    22201 tcttctgcat attcttcgtc tgtttttccc tcgttaagat atatacttgt ttctatttcg
    22261 tattctcttt ttttcagata ttcttctaca ctttccttac cattccattc tgttgtggct
    22321 gtatgccctt gaacttcaat ttgataatct cttataaaag gcttatcttg aaataaagga
    22381 gttgcaagtt cttttatttc atcaaaatag taataaacat ggtaactgtc ctcaaaaagt
    22441 ccagtatttc gtgtatatac agtagcagtt tgagaagaat tttctttact ggaaacttct
    22501 gccataatcc agtttaatcc tattttttct tctttgtact tcttcacttc tgtaatgata
    22561 aattcttcat tgtatttgtc ctttaatttg gataagatat atttttgtgc ttcttcacta
    22621 gagttaaaat catgcgaata accgctacaa ctatttaata gtcctagaca aagcacgctt
    22681 gctataacac ctaataaaat ttttttatat cgcataatcg ccacctcaat gtgatttaat
    22741 acaattctac aaactgatag ttataagtca gtcaaaaaaa tttttgaaat atcttttttc
    22801 tgaagtttgt atttttgaac ttgggataat ggaatttcaa atgctgtgct tgtctttgga
    22861 aatttattgt tcaatatatc atcatagaga actgtaataa atctccccca ttcttttaag
    22921 tcagctgtct ttgttgaatc gtctaagaaa gcataaccat cacttaaata aaatatctct
    22981 aatgctagtg ctaaatcaca actggagtca gcaagtattt gttttggaat ttcaaatccg
    23041 tcatcccagt tatattcatt tagcttactt ctcaaatcat tatatatcat ttttatattc
    23101 cccaaattct aatttgcatg tatgaaatat aggattataa tcttaccatt catttatggc
    23161 atacaaaata gcaagtctta cattttttaa caactcagaa gatagagttt cgtattcttc
    23221 agataaccct tttttgtgag ccatatatgc tgggctatca ttccacgaac ccattgctcc
    23281 aaaaacatcc gaaatacttg cagcttcgaa catttgaaga ttttgctgtg gaattggtgg
    23341 taaactcaaa ccatactttt catctggata ttcgctacag ccatctaaaa ggtttatagc
    23401 agaagtaaaa atattagcaa aattttcaca ctcaattttt ttagccaatt ctttaatcga
    23461 taataataca tctcgaaatg agttaatgtt attctcaaaa tatggttttt ttgatggtgg
    23521 gttagtccac tcatgctctg aatatagaat attccatttt ttttgcatag agtcaaattg
    23581 ccaatcagca gtaaagtatg ttacttttcc gcttttgtaa aaacacaaaa tggaactttc
    23641 tgttgtattt gaaaatccta aaaattgtct atcctttact gaatatggac atagcaactt
    23701 tatatcctgt atcccatttt tctttatttg ttcaaaccac aatgaaacat tagaagcagt
    23761 atatttttct gtccttaaaa atttcttttg aggtaaaaag acaaattcaa ttttattctc
    23821 atattctaat tgtgaaaatc taattggttc tgataattgc aacgcttttt tgctcgtcgc
    23881 tacaatagat gcaatttgaa acatttgtcc attcatcatt tcgcctcccc ttaatatgaa
    23941 taatactgtt ctttcaaaaa ttctaatttg tcgctttttt catatccata ttataacagt
    24001 tccatatatc tgccacaata aaaatcaaca taccctttaa atattttctg cattgaacat
    24061 acacactttt tctttcttcc tcttgattac ccaccacaga aaagaaaaag ccctgtcaag
    24121 agccttgcca ccattggtgg tgctttgcac tctttactgg gctttttgtt tgctgtatct
    24181 tccatgcaag aggaaattaa agacctctgt tccatttcgc ctttagataa tcttcataat
    24241 ctccctcatt aaagtctact tgtggagaag tattaggaat attttttctg ttatctatat
    24301 ctgcaagttg acggaatatc cagtcatcat aagggttgtg atatttgtat tctttcggct
    24361 gttctctgta tcggtctaac cctcgcattt ccttatgtac tttcatcatg cgttctattt
    24421 tttgacgctg tatcaactgt ttgatttcca taagttcttc aatttctaca acctcattag
    24481 aaagataatt gctgatgtat ctaatcaata tggtttccat gtaaaatctg tattcgtttt
    24541 cattatcgaa aaattcattt tcagacagat aatctaaaga aacattgaag tcctgttccc
    24601 gtttgataat atccatgata tatggctcgg tgtggtcgat atacttccat tctcccgaca
    24661 ataattcatt gggcgttact cccagcacgt ccattatctt ttccagcgta tcaaaggtgg
    24721 ggtaattcac acctcgttca atcttggaaa ggctctgcat attgataccg attttgtccg
    24781 ccagttcctg ttgtttcatt cctctgtgtt ttcttatggt ctgtatgttt tctcctaaga
    24841 aactgatttt cttttcgtaa tgctccatga cttagtataa acactccttt cattgctttt
    24901 cttggtattt ataagcatat catacttaat atatatcaaa aagtcaacaa aaaattcttg
    24961 acaagtaatt ctaatggcgt tattatcgta tcagatagag tgattaagca caatagggtc
    25021 aatcacacgc ttgagtaagc atagaaaaga tgtgttttca ttttgatagc atgaataagc
    25081 atggactatc agaccgaaaa taaggtttct gactggggct gttccgttta gccacgagcc
    25141 ttacaaggct cgtgagcgtt aagaacggat cagacacagg aagaaaagga acgcctttag
    25201 gcgttcataa agggcgtata tgtaacaccg ccctgcgcat acatgtcata gtacctagaa
    25261 actgtgataa ataaaggaaa aaacacgatt tttaccccgc aaaaaaacgg gaagtacgaa
    25321 aggagaaatg cactataact acacacaaaa atttatccgt taagattgat tacatcagta
    25381 ttgtatttga tactgcaacc gctgaagatg taatcatgca cattttaggt ttaccgactg
    25441 acattttcaa tgtctatccg gcaagcatta aatacaaaac ctatcaagca cgctggcaga
    25501 ttggagatat ttatgtatcg ggggacgcaa gaaaaacaga ggataaccca cagggactag
    25561 gctgttatct tgttatgact ggcagaggtt gtgatgatat tttccgtatt ctcgacagta
    25621 ggaattatac ctttggggat atgttccgac gctgtgagcg aagatacgga ctggataact
    25681 tccacttcac aaggcttgat attgccattg atgataagaa cgaaaagcca ttctttacca
    25741 tagagcagat aaagaagaaa tgcgaaaaag aggaatttat ctccaatagt gagggctacc
    25801 actttgatga aagcaagttt gacgatttcg acaccgcaaa gactgtttat atcggtgctg
    25861 gaaaatctgg attatcctac cgcttttatg ataaggataa ggaagtctgt tcaaaacata
    25921 ataagacgct tgaggaagtc ggcagttgga aacggacaga aatgcaactg cgtgatgata
    25981 aggctcatgc ctttgccatg acatttaaag acagaccgct agaacttggg gaactggctt
    26041 tcgggctatt ggcaaacaac ctacgctttg tcgtgccaaa cagaaacgaa agtaataaaa
    26101 gcaggtggaa aacgtgtcga ttttgggaac gctttttagg ggctgtggaa gtcttgaaac
    26161 tgcaagtacc aaaacagcaa aattcccttg aggaaacaca gcaatggctc acagagggtg
    26221 gcgtgatttc cgctgtcaaa agtttttatt tcttagaaga acatgacgca ttaggtggac
    26281 tggaaaaagt aggaactatg cttgataagg caagatacag caattccctt tccagtaaat
    26341 taaccgccca tttacagagg ataaaccgca ccgaccttat cccctatatc cagtatgaca
    26401 cgaaacatgg gaaagggggt atctgatgaa gaacaacgat attcccgtat gggaaaaata
    26461 cacccttacc attgaagaag cgtcaaagta tttccgtatc ggagaaaaca agttaagacg
    26521 attggcagag gaaaacaagg acgctggctg gctcattatg aatggcaacc gcatacagat
    26581 taaacgccga caatttgaac aggttattga taaattggac gcaatctaat gcaaatgagc
    26641 cttgtatgtg ttatgatgaa cacaagtcat atcaaggctc tttccaacaa ggaaaggagc
    26701 agacaccatg aaagaaaaaa gacgggataa caaaggtcgt atcctgcata ctggagagag
    26761 ccaacgaaca gacgggaaat acttatataa atatgtggac gcatttggaa acacaaaata
    26821 tgtgtatgct tggagattga cacccacaga cccgacacca aagggaaaac gggaaaaacc
    26881 ctcacttcgt gaactggaac agcagataag acgggatatt gaggacggta tcgacagcac
    26941 aggcaagaaa atgacgcttt gccaacttta cgccaaacag aacgcacaga gggcaaacgt
    27001 aaagaaaagc acaatgaaac aacgggaaca actcatgcgg ttattgaaag aggataagtt
    27061 aggtgctagg agcattgata caatcaagcc ctctgacgct aaagaatggg cgttacgcat
    27121 gaaagacaaa ggcttttcct acaataccat taacaatcat aaacgctcgt taaaagcgtc
    27181 attctatatc gccatacaag acgattgtgt aaggaaaaat ccctttgatt tcaagttaag
    27241 tgaagtccta gaaaatgata ccaaagagaa agtcgcattg acagaggaac aggaacaagt
    27301 cctactctca tttatcaaga cggacaatgt gtatcataag cattatgatg atgtgctaat
    27361 attattaaag acaggacttc gtatctcgga actgtgcgga ctgacagtag ccgatattga
    27421 tttcaagaat gaagttgtga ttatcgacca ccagttacta aagagcaagg aacagggcta
    27481 ttatattgaa acgcctaaaa caaagagcgg aataaggcaa gtgccattaa gcagagaaac
    27541 gatacaggca tttcaacggg ttatgaagaa acgcccaaag gcagaaccat ttgtgataga
    27601 cggacggagc aattttctgt ttgtcaatca taaaggcaag cccaaagttg cgattaatta
    27661 taacgcctta tttatccgta tggtaaagaa atacaacaaa caccacaagg acaatccctt
    27721 gccacatatc acaccgcata cgctacgcca tacattctgc acaaggctgg caagcaagaa
    27781 catgaacccg aaagatttac agtatatcat gggacattca aacatcagta tcacaatgaa
    27841 ctggtacgct catgcgtcca tagacaccgc aaaatcagag gttcagcgtc taatcgcata
    27901 gaagtattta ccacgatttt aaccacgatt gatagggaaa atataagaag atagacctag
    27961 atatgtgagg tttaccacaa aagaaaaatg cccgtagagc cgataaaata aggctttgcg
    28021 gacatttaag aagatataaa aagatagtca aaaagacata tataatttag agtaattaat
    28081 ttatttttta acatacaaat gattttatga aaaaaaacaa gactcaaaaa tttttatatt
    28141 ctttgataga ataaaattga gagtaaattt attgaatttt ataaaattta taaggggtga
    28201 gtctaagata tgcatgaaga taaaaatgat atatttgaat caatagatac tgaggatttt
    28261 gataataaaa cagaagaaga atgtttagag ctagtaagaa aaaatggatt gaatttaata
    28321 tacataaaaa atcaaacaga agagatatgt ctagaggctg ttagacaaaa ttgtaatgca
    28381 ataaaatgtg ttcagaatca gacagaaaaa atatgtatag aagcagttaa acaagattgg
    28441 agaatgttag aatttgtaga agagccaaca gaagaaattt gcatgttggc tattaaccaa
    28501 gatggaacag cattaaaata tatagaaaat cagacagagg agttatgctt aagagccgtt
    28561 gaaaaaaatg gtgcagcttt ggagtatgta aaagaacaaa cagaagaaat atgtatagaa
    28621 gcagttagaa acagcgaatt tggattggca agagtgaaaa atcaaacaga aaaaatatgt
    28681 atggaagcag ttaagcattg tagctataat ctaaaatggg tagaaaatca aacagaagaa
    28741 atatgtatgg aagcagtgag acaaaatggg cttgatttga aatttgtaaa aaatcaaaca
    28801 gaaacaatct gtttaagagc agtaagacaa aatggaatgg cattagaatt tgtaaaggaa
    28861 cagactgttg gtatatgctt aaaggcagta agacaatatg gaatggcatt aaaatttgta
    28921 aaagaacaaa cagaagaaat ttgtacagaa gctataaaac aagataaaag agcacttagt
    28981 tttgtaaaag gagataagga aaaatacaag gctctatatg ataataatga accatttgca
    29041 aagagatatg ttagaaatgt aatagaaaaa gaaaacagag cattgattaa aaaaggagaa
    29101 gaaaatgcaa aaatcaaaat tgcaggaaaa ctttatgata gaggcatgtc ttttgaagat
    29161 atatcagata tagttgagat tgaaataagc aagttaaaag tgagtttagg tgttttttaa
    29221 gggaaatagt taataaaaaa ataatcgact agctctttgt aggacagcaa aattagtgat
    29281 ataatttgat gtataataaa ttatttttat tagataaggg ggaattaaag ttgaagatta
    29341 cagtattata ccaaacaaga agtggaaaca cagaaagggt cgctaagctg atagaagagg
    29401 gcgctaaaaa ggtggatgga gtagatgtaa agcttatgag acttgataat attgatttag
    29461 attatttaaa tgaaagtaaa gcagtaatat ttggaacacc tacttattta gcaaatacaa
    29521 cttgggaagt aaaaaaatgg tttgatgaag attcaaaaaa agttaattta gctggaaaat
    29581 taggagctgt ttttgctaca tgtgattata tatgtggagg tccagatgtt gcgatactta
    29641 ctatagtagg acatttgatg gttaaaggga tgcttgtgta ttctggaggt ggttctttag
    29701 gaaagccatt tatacattta ggacatgtac attcaattga aggtccagag ttacaagatg
    29761 agaaggctat aatatttggt gaaagaattg ctactaaggc aaaagaacta tttgcttaat
    29821 ttctatatgc ataataatga ttagagtaaa tttagggttt taatggagat ttgaagtaaa
    29881 agttataaaa taaaaaattt tccataaaat tactcaagat gaattataat ataattataa
    29941 ataaattata ttattaaaat atttaaaatc aaacgtcaat agcgagggaa gtttatggta
    30001 tggcatatag aatatgagat tttttctgca attatagtta tttttttaat ggtatacttt
    30061 tttagaagta aatttatacc tactttacaa aacaaaatat attgtgcact tttaatattc
    30121 tcatttttat ttataatttc aaatatttta ggttcatttt gtctaaataa tatagacaaa
    30181 attccaattt ttattacttt tttattgaat cagatatact tattgttatt gccaatacca
    30241 gcagcacttg tatcatttta tgttatggct attatttatc aagatataag gtatatgaaa
    30301 aaaagattat tatttttatc tataccactt ataatttgta taatcttatc tattacaaat
    30361 ccttttacgc atattctatt tggattgtca aaagaaacag gttatatacg aggttgtgga
    30421 tatgttgcaa cttttgcatc ttttttcttt tatgcaatat attcagcatt tttatctttt
    30481 aaatatagaa aagcaatgca tgaatcaaaa atatgggcta ttagaggttt tcttatagtt
    30541 tcaattgtgg caattatctt acaggcaatt tttttacagt atcttcttac aggaactgca
    30601 tgtgcatgta gtttactttt gacatatctt tctatgcaga atcgaggtct tattattgat
    30661 gaccttactg gtgtactcaa tagacaatct tttattcaag agctagattt gaatatcaat
    30721 actgaacaat caggatttat tattacaatt gcgcttgatg attttaagtt tatgaatgaa
    30781 acttttggaa caaaaaatgg agatattgca ctaaaagaag ttggaaaata tttgattcag
    30841 atacatgatg taaaccatgt atatagaata gggggagata tattttctat tgttgtcaat
    30901 agtcaattag gtatagaacc agatgatatt atcagaaaga tagaagaaag atttaaaaag
    30961 ccttggctag tagaagagat aagttttaat ttagcaacta gtattgctgt tgtttattac
    31021 ccagaaaatg cagaaacgac agaagatgta attgttgcta tagatttctc tatacatgaa
    31081 gcaaaacgtt ctgagtcaag gcgagttgtt tatgcagatg cgtctataag tgaaaagata
    31141 aagaagaaac atgttattaa aaattgttta aaagaagcat taaaaaatga tgggtttgaa
    31201 gtgtactacc aacctatatt ttctaatagc aggggcaggt ttacttcagc agaggcatta
    31261 cttaggctag aacacaaaga gttaggtttt atacctcctg atgaatttat tccaattgca
    31321 gaacaaacag gattgattaa ctcaattgga ttagtagtct ttgagaaggt atgtagattt
    31381 atagctagtg atgagtttga agatttaaaa ttggataata tagctgtgaa tctttctgta
    31441 gtacaatgta tgcaaaaaaa cttagctgat gatttacttt atcttatgaa taaatataat
    31501 gtatcaccaa ctaaatttaa acttgaaatt actgagactg tggctatggg ctcttttaat
    31561 ataattaaag aaacaatgga aagattaatt gatttaggtg ttaagtttgc acttgatgat
    31621 tttggaattg cttattctgg agttactaat atgctttctt taccattttc agtaattaag
    31681 ttagataaga gtttgatttg gtctatgaat gaagatagta ggcataaact tacagttgag
    31741 acgattatag ctcttataaa taaattgaat atgaaggctg tagcagaagg tgttgaaacc
    31801 attaagtgtg ctgaagattt aatagctatg gagtgtgaat atttgcaagg gtattatttt
    31861 tctaaaccag ttccagaaga tgtttttaaa aatttgttga aagaaaatac ttttacaagt
    31921 taacaccctt tattttttta attacaactt tgttcattga cactgccagc gatatattat
    31981 aaaattaaca caataataaa tattaaattt attatacata ttattaatat taattaatgg
    32041 agtaaagatt tattatatat tttatttaat tatcctaaag tgagaaagga agatgtgaca
    32101 tgaataaaaa gaaaatatta gtgccaattg atgggacaga aagaagtatg cattctttgg
    32161 aatttataaa aggaatattt aaaaaagatg aagttgaagt agaaataatg aatgtaaaag
    32221 aactagtatt tattgatggc atatccctgg ctgaagagat aaaaaattct gaaaatttag
    32281 gaagaagaat cttggataaa gcagcagaga taatgggaga gtatgatgtt aaagtacatt
    32341 ttacttttgg atatccagga gatgagataa ttagaaaagc aaaagaagat aatgtagatt
    32401 ttatagttat gacaaaatct actaaaaaag gtcttacaag aatgataggt tcagtaacag
    32461 caagtgtagt taaacaagca aaatgtatag tgatgattgt accggagtag aattagaaag
    32521 gtatttgaaa tatgaataaa aagatagtag cagtttgtga aagtgaaaga agtttaaatt
    32581 ctcttaagac agctgcaaat gatttaggat ttgatttagt ttatgaaatt caagaaaatg
    32641 ataatataaa aaatgaactt tctatttatg atatagaaga tgcatccata gtgttatttg
    32701 ttacaagtga ttctatagaa agcatagaga agattgatag atttatagat agagaatttt
    32761 atgaagttga tccaaagtat ataatagagg atgcaaaatc tatagtaagt gaaattttaa
    32821 tagacttaaa ttaatcgtgg gtgtcgcact aagaatagag cgacgccttt ttatatattt
    32881 tacacaagaa ataaagaggt tgtatcaaaa tatagataag agtctttttc attgttgaaa
    32941 tgatgaaaat atatttgatt tcatacaaaa aagagtacct cataactaaa aagttcactt
    33001 tgagacactc catttttata tgttagttgc atttaaggta aaatagaagt ttaatcatgt
    33061 tgaaataact gaattacatc ttctaaatga ttgtacattg atgtataacc taagtaagag
    33121 tctttactat caaatgcaat cattatcttg ttatggtggc taatcatatc cttgagagaa
    33181 tttctatatt taaaaccaaa gtattggtta gaagaaactg ttttaggtat taactcataa
    33241 tattttataa aaattggatt atgagaagct aaaattatct ctttgtgaaa ttgcaagtca
    33301 gcatcataac attcttctat caaaccgtga gaaaccttat ccaattcttc tattgacttt
    33361 aggtaagtat attttatttt ttgaagttct ttagatgtag catttaaaat tgctagttta
    33421 gtagcttcac tttcgataag ttgtcttgct cttaaagatt ctacataaaa ttcttgtatg
    33481 ttatgatttt tatagatttc accatcatca aataggtcaa cttttttaaa tccttcaact
    33541 ataggacttg aataaggcac agctctaagt attccttcct tacagagtat atttatggca
    33601 tttcttacag gtattctact tatgttaaat aggtcagcaa tctttctctc acttggtaat
    33661 ttactattaa ttttaaaagt tccatttaga atgtttaatt taatataatc aataattttt
    33721 tcagtggcat ttaagctttt cataaaaact cctaaacata taattttttt atgattgtat
    33781 tatatcatag ttaagagtta aatctacttt tttataatat gtataagaca ggatagaggc
    33841 caaaatagct ataatagcca agataaagta tccatattgt attgaagtat attccgatat
    33901 tttaccaact atcattggaa atacagacat tcctatagca taaattgctt gaaaaaaacc
    33961 cattgcagta gatttctgat gttttggtac atttttcata gactcgctag taaggtaaga
    34021 aaggagtata cctgtagata tacctggtag tacttgtagt acaaatatta tattaatatt
    34081 ttttattgtt ggaactaaaa agcaataggc tgaaactaaa ataaaaacta aaggaatcca
    34141 aaattttggc ccatacttag tacaaaattt agtagaagca aagccagaag aagcaacagc
    34201 acacaccatg taaaatatag aagatagacc tatgagggta gaactagaac ctaagttttt
    34261 aagaatttga gtagtaaatg acattgttgt agacatttga ataccctgtt gaattaatgc
    34321 cataaaggaa aaaaatacaa gtcttttatc cttgcagata gataaatatt ttttaattga
    34381 tattttttca ggtatttttt ttgaattatg attttttata tttaaggcta gaatcgttcc
    34441 aataactgaa gacaatacac tcatgataca taaggctgtc attcctaatt tttcataaaa
    34501 taaagtactc ataacaaatc caatcaacat tcctagattg tttactaata ttattgtact
    34561 tgtagctttt tgttgatgtt ctgtagaaaa aaagttggta tagtgaacca tgtaagaaat
    34621 ccaagttgat gatgatattc cagataaaat gttagctata agaaaaccat tgcctccagg
    34681 agaaaagact cttataagag atgctaaacc agcaaagaaa attccagaca gtataaatat
    34741 tttatgttta tttatggaat cagcaaatac tccaacagga agccttaata aacattgtga
    34801 gattccatat gcacctatta ttataccaat catatttgta gatacattac atgcacttaa
    34861 atatggattt tggaaaggta tatatacata ttgtgaaaac cagaaaaatg taacaataga
    34921 aagtaaaagt aatttttgat tagatatttt tttcatatta tcctccgtat ggtattttta
    34981 taatgcaaat aatataccat ttggattttt taatcaagta ctttctctat taaaaaaaat
    35041 ttaaatatat aattattatt tacaaaaaaa ttatacttta tagttgaatt aagaaaacgc
    35101 ttatgatact ataaagttaa caaatttgaa tatataacag tagacgtgtt actggtaatg
    35161 caggcaagat cgaatcaatt tttatagatt atctatagag tactatgggt ataatctatt
    35221 tatttggttc gatttttttg tttaattggc cataaaacaa aaagcctata gttgaaaatg
    35281 gaggattttt tatggattat aaaaatatag ctcaagaaat tctactaaat gtaggaggaa
    35341 aagagaatgt aaatgaagtg actcattgta tgacaagact tagatttaaa gtcaaaagcg
    35401 cttctaaagt gaataaggat aaattatcta aaactgaagg agtaataact gttgttgaga
    35461 gtatgggtca aatacaagtt gtaattggaa ataaagtaaa aaaagtatat gatgaggtta
    35521 taaaaattgt acctcaatca aataacgtag gtaaaaagaa tgaaagtcaa gaaaagcaag
    35581 gtataattaa ttctatatta tcagcagtag ctggtatatt tacacctaca atacctgcta
    35641 tagcaggggt tggtatgatt aaaggtattt tatcagttct tgctatgtat tatatgaata
    35701 aaaatggagt agatataaaa gaaacgcaaa gctatattat cttaaatgcc atggctgatt
    35761 ctatattcta ttttatgcct attatactag gatatactgc ggctaaagta tttaatgcaa
    35821 ataaaataat atctatggta ttaggagcta cactttgtta tccaactttt actgctttga
    35881 tggcaggtga agaatctgtt agatttttag gattggcagt aacaaaagct acgtatacat
    35941 catctgttat tccaataatt attgctatat gggctctttc atacgttgaa aaagtattag
    36001 aaaagtatat acctgaggta attaaaataa taatggttcc aactttatca ttggtagtaa
    36061 tgttacctgc aacattattt ttatttggac caatcggaat ttatatagga aatgtcataa
    36121 acttttctta taagtatatt tatgaattaa gcccagcatt gtgtggagca tttgtaggtg
    36181 ggttatggtg tgtgttggtt atatttggtg ctcatagagc attattacca ataggtataa
    36241 gtgatgttgc tcaaacagga agacagaatt tattggcatt tgcaggagct gcaaactttt
    36301 cacaagcagg ggctgctcta ggagtattct ttaaaactaa aaatcaagga ctaaaaacaa
    36361 tttctatgtc tgcaactata acagctttat ttggtataac tgaacctgca atatacggtg
    36421 ccaatcttag attaaaaaag cctatggtat gtgccgtaat atgtggtgca tttggaggtg
    36481 cgataatggg aatgggtgga gcttatggta atgcatttgc aaaccaaggt gttttaacta
    36541 tacctgtata tgctgaagca ggtgcattag gtttcttaag ttatctaggt ggttgtgcta
    36601 tagcattttt tggttcagct atttcaactt atctagttgg atttgaagat ttggaagagt
    36661 cttctaataa ggaaaattca tctataaaag tagaaacgaa ggatggtgtt attgatataa
    36721 cttcacctgt agagggcgaa tgtatagaat tgtcagaagt aaaggatgat gtatttgctt
    36781 caaaagctat gggagaaggt atagctgtgt tacctacaaa aggagtaata acagccccta
    36841 ctgattgtga agtagcttct ttatttccaa cattacatgc aataggatta aaattagata
    36901 atggagcaga aatgttaata catgttggaa tcaatacagt agagttaaat ggtaaatact
    36961 ttaccaaaca tgttaatcaa ggagatttag tgaaaaaagg tgataaactt atatcgtttg
    37021 atatagataa aataaaaaag gttggttatg atgtaactac gccagttata gtaaacaata
    37081 catttgattt tgggcaagta gtttcttgta aatctagtta tgtttcaacc aatgataata
    37141 taatttcatt agtattagct ggtaattaag ttaatttgac tagagataag taaattgatt
    37201 taaaaggaaa taagtaaatc aacaattaaa tacatctaaa agtaagttta ttgcaatgaa
    37261 ttgttaaaga aaataattaa tatggagtaa atctattgca atgaagtaac aaagaaaata
    37321 attaatatag agtaagttta ttgtaatgaa ttgttaaaga aaataattaa tatagggtaa
    37381 atctatttca atgaaataac aaagaaaaga gttaatatag agtgaactta ttgcaatgaa
    37441 tcaacaaaga aaataattaa taaaaaggag aaatatttat gaatacagga tttccaaaag
    37501 actttttatg gggagcatca tcttctgcat ttcaagtgga aggagcttgg gataaagaca
    37561 ataaaggaaa aaccgtagcc gactataatt cttttaaaaa gtctcattta caggcagata
    37621 ctaaagtcgc atcagacttt taccataatt atgaagaaga tattgaatta atgaaagaat
    37681 tagggatgaa aacatatcgt ttttcaattt catgggcaag gataatacca gatggtgaag
    37741 gagagataaa ccagaaaggt ttagactttt ataataagat aatagacaaa ctaatagagt
    37801 gtgatattga gccattcgtg actttatacc attttgacct tccatttaaa ttagtagaga
    37861 aatataatgg ttgggaaagt agagaaactg tctatgcttt tgaaagattt gctaaaatat
    37921 gctttaagca ttttggagat agggtaaagt attggcaacc tcataatgaa cagaatttaa
    37981 ttgttagagt ggaggagaga attaatatat atgatgaaac agattcatgg aagatagata
    38041 aaatgcgtgc tcagatggat tataatcttt gcttagcaca tgcattagca gtcaatgcat
    38101 gtcatgagat gataaaagaa agtaaaattg gagcagcagt atcatcatct gtaacatatc
    38161 ctcttacttc taagccagaa gatatatatg cagctagaat gaatgataat tttaaagtgt
    38221 actatatgct tgatatgcat cattatggag aatatccagg gtattatatg aagtatcttg
    38281 aaaaaagaaa tatagttcct cacatggaag atggggataa agagatactt aaaaaagcta
    38341 aaatggattt tatagctgta aattattata ggacaaattg tgcagaagct ttacctgaag
    38401 attcacaaca tccatttgga ttaagagaag gaactgttga ttttagtatg tatggactat
    38461 ttaaaatgtc aatgaatcct aacttagagg cttctgagta tggagcagca atagacccat
    38521 caggtcttag agttgcctta aatgaatatt ggcaaagata tcacttacct gttataataa
    38581 cagaaaatgg tctaggagct aaagatatat tagaagatgg aaaaattcat gatgactatc
    38641 gtatagacta tttaagaagt catataaatg catgtaaact agctattgaa gatggtgtag
    38701 agatgattgg atattgtcca tggtcattta cagacctttt aagttcttct caaggtttta
    38761 ataagcgtta tggacttgtt tatataaata gaactgacca tgaaatttta gatttaaaaa
    38821 gaatcaagaa agatagtttt tactggtata aagaagttat agagaacaat ggaatagtaa
    38881 aataaacata aatatatatt gagggtttta gtatgtacat tacaaaggta ttaaataatt
    38941 cgttgctact tgcaaaggat gataatgatg aagaaataat attgatgggg aaaggcattg
    39001 gccataatta taaggccggg tctgagttaa atgaaaaaga tatagaaaag atttttgttc
    39061 ttcatgatga aaatataaaa aagagtatta tacaattggc aacagaaata gatgcagaat
    39121 attttggtat agctcaaatg ataattgcat atggaataga aaaatataac ttaaaactta
    39181 tgaaccatat atatttggcc ttaactgacc acattgcctt tgcagtgaga cgttttaaag
    39241 aaggtataat gattgaaaat cactatttgt tcgaaatcaa ggaatttaat ccaaaagagt
    39301 atgatatagg aaaatatgct attactgttt ttaaggaggt tcttggttta gacctaccag
    39361 aagaagagat tggtaatata gcaggccatt ttataaatgc acaacaagat aatccttata
    39421 gtgatagaaa taagagaagt gctaaaattg taaatgctat tttgcaaata gttcattatc
    39481 acttttctat tgtatataat aaagagtcat tttattatag gagatttgta atgcatctaa
    39541 aggccttttc acaaagattt ctggctaatg aaccatcaag agaaaaaata gattttatat
    39601 atgagcaagt tcaaaaaaat tgtaaggaag agtatgaatg tgtgaaaaag gtaggagctt
    39661 atatgtataa ggaatactcc agagaattac caagacaaga ggagttatat ttgatgattc
    39721 atattcataa gattttagga gaattatgcg aaaatagtta gaatatctta atatgctagt
    39781 aatattataa aaaattaaaa attaactgca ctttaaatat gaataattgc attacttaag
    39841 ggggttgtct taaaattgat ttttttaatt aaatttgaag ctcaactcct tttttaaacc
    39901 tttatatcat tacaacttta atgtttatac gcctgtactt cagatgtata tctacttttt
    39961 acatttctca acatgcaaat ctaccattct gtatatagta aatgtattat catgtttgtt
    40021 ttattcaagc acacttataa tacgcttgat tttttcacaa tgatgaaata tactaatggg
    40081 tgttataggt ataagaatcg cattacactt gaagaagtaa gtgataaatg agatataaat
    40141 cctcatatga taaactacta tttcattgag gaacatattc taagtgatgt caagatacta
    40201 caatatgact aaattcctag tgataaaaaa gtctacgaat gagtgtagaa aggggaacta
    40261 agatgaataa agttttaatt atagatgatg ataaagatct ttgtattttg ttaaaaaaga
    40321 gtatttcaat tgaacagatt gaagcaaact attgccattc tgggagagat ggactggttg
    40381 aactttcaaa acaagattat cagttagtag ttctagatgt gatgatgcca ggtatggatg
    40441 gttttgaaac tatggaacaa atacgaaaat atagcagtat tcctatctta atgctgacat
    40501 caaaaagtga taattacagc aaagtgcatg gattgcgagc tggtgcagat gactatctaa
    40561 ccaaaccatt tgaaattaca gaatttactg ctcgtgtact gtctttaatc cgacgttaca
    40621 cccgttttaa tccaaaaaat gaggagccac agcaactttc tttcaaaggt ttgttgattg
    40681 accttgacca gcatacagtt actaccaatg gcgaacctat gttgcttcca cccaaggaat
    40741 ttggtgtact tctttactgt gcaaggcatc agggtaagat tttgacaaaa cagcagattt
    40801 atgaagccgt gtggggtgag ccatatgtat atgatgacag caatatcatg gctattatca
    40861 gtcgcctaag aaaaaaaatt gaactagacc catcatctcc catctatttg caaacaataa
    40921 aaggaattgg gtatcaattc aacacggagg tatgaaaatg gatgaacaaa cgataattct
    40981 tttcttactc ttgctgtcga ttggtctact ttttctttcc atatttgctt tttccaagct
    41041 tgggcatatt cacaaacgct taaaagatat agaggagata ctcgctgatg tacaaattgg
    41101 agacgaaaat cgtaaaatac taattaagcc atgtgatgtt atggctccat tggtttatca
    41161 gcttaatgag attgtctacg attatgaaaa taagttactt tctctgaaaa agtcggataa
    41221 agctagcaaa caacttatga caagtttatc tcatgatgtt cgtacaccat taacaactct
    41281 gattggttat ctggatgctg tacacagtgg tatagttatc gaacaagagc gggaggaata
    41341 ccttgaaatc gctaggcgta gagcctacga cctcaaggat tacattgatg ttctttttga
    41401 ctggtttcgg ttgaactctg atgaatttac gctgtcaata gaatctgtgg aaattgcaga
    41461 gttgtcacgc aatattttga aagactggat tcctatattc catgaaaaga aactgaattt
    41521 tgaaattgat attccagaaa atcgactaat ggtaaacctc gacccagatg gatattcccg
    41581 tgtggtcaat aatctggttc aaaatgttct tgctcacagt aaggctcggc aaatcaagat
    41641 taccatgagt gaggattcca gaatggtatt actccgtgtt gaggatgatg gtgttgggat
    41701 tgccagagaa aatttaccac atatttttga gcgactgtat aagtgtgata aaggacgttc
    41761 agaaaaagga agtggtcttg gtctatctat tgtcagtcaa atggtggagc gaatgggtgg
    41821 tcaggtttcc gtagaaagtg agattggaaa gtataccgta tttacagtga gcttaccatt
    41881 aatataaaat tgtttttccc ccatgtgaca tgtatacaca gggggatttt ttgtaagtta
    41941 taaagttgca aggttaatac aaggttgttg caaggttaat gtaagattga ggtggtatga
    42001 taactttaat aaacaaagga ggcttttatt atttatgaat aatttaatta ttgaaacaaa
    42061 aaatctcact aagcaatatg gtgctcaaaa gagcgtttct aatttgaata ttcacgttca
    42121 gaaaggtcgc atttacggat tgctaggaag aaacggtgcg ggtaagacga caactatgaa
    42181 aatgttattg ggcctaacaa aaccaactac tggagaaatt aaaatatttg gtcaggacat
    42241 tcacaataac gagaagaagc ttcttcctcg aattggatgt ttgattgaat caccagggtt
    42301 ttatcctaat ctgacaggaa cagaaaatct caaaatcttt gcaaggctta gaggaatacc
    42361 aaaaaaaaat gcagtagaat cagcactgga tgtagtcggt ttgccaaaca atgacaaaaa
    42421 gttattttct caatactctc ttggtatgaa acagaggttg gcgattgctc ttgccattat
    42481 gcatgaccca caactgttga ttttggacga gcctatcaat ggacttgatc ctattggtat
    42541 tgcagaagta agaacgttta ttcgtgatct ctgcacagaa cgaggtaaaa ctattttgat
    42601 ttccagtcac attctttctg aaattgcctt gttggcagat gacattggca ttattgacca
    42661 tggtattttg ttggaggaag aaagtcttgc ccaattagaa gaaaaaaaca gtaaatacat
    42721 acattttgct gtatctgatg cagcacaggc agcaaggctt ctggaaaccc aacttaacct
    42781 gaaaaatttc aaagtagcag ataattacaa tattatgcta tatgatacag atgtttctgt
    42841 tgcagaaata aatcgtgctt tcattctaaa caacattgag gtatcagaat ctcatttatg
    42901 cgaagatact cttgaagatt acttcaagaa agtaacaggg ggtgaaggaa ttgcttgata
    42961 taatttcatg tgaattttca aaactcaagc ggttaaaatt tatactgatt tctattttag
    43021 gtgcttgctt atttccaatt cccgcaacaa ttttgattgc aaaggacaac ttgccctttg
    43081 agcaattgtt caaattagtt gtcaattttg gatatttctt gctattacca attgtattaa
    43141 gtattgttgc tagccaacta ttttttatag aaagagataa tgatgtatta aaaaatcttg
    43201 caacagtgcc agtgccaaaa ggaaaactgg ctctggcaaa attggctgtg ttgctgttta
    43261 tatcattgtt ctactctgtt gcagggttag gagctactat cattggaggt ttcattgttg
    43321 gaatagtaga gggggttgct gtaaaattag gaatgagcat tgcttttgga attatgtttt
    43381 ttgttactgt acttcctgtt gtggtactca ttgtatattt caatcgcagc tatatttttt
    43441 ctattatact ttcttttgta tatgctattt tcaattttag tatatcctta aatattatca
    43501 attttgaacc aaataaccca ctattaagcg tattacctgc tcctgttata atgcgttggt
    43561 ggatggcatt ttggggagat cccactggcg aatacacggt acttagacag ccatatttgc
    43621 tctcaactcc tgcttgtgta ggtattttat gtttgataac cattatagca gtcctgctga
    43681 tttgtatgat atacaaaaag caggagaatt aggaggtatc tatgcttgat ataattacta
    43741 cagaatttca aaaaataaaa agatataata ttctatggat tggtgttgtt gctgttctgt
    43801 tttcagcact attggcagtt tttcaggttg taagttcaca cggcagtgac cctctaacgt
    43861 atgagagctt tgcaaacgga gttatctgga ataatttcag tcttagtttt ccatttggga
    43921 ttacacttat tggaggatat cttattaacc gtgaatatac agaccaaacc ttaaaaaaca
    43981 tcctaactgt tcctatttca ttacgcaaat tgctagtggg aaaattaatt gcggttggag
    44041 gaattactgt attgttaagt cttttcagct tcttatgcac atttattttg gggttgttat
    44101 tttgcaatat caatatatct gttatactcg ttgtaaaatc cttagttcag attttgtctg
    44161 ttaatctgta ttgttatgtt gctgttttgc cgattattgc ttattttggt cgtaaacaaa
    44221 atgcatttct gacgggtgta gggattgcat ttgtatacgg tttttgtggt gtgtttgttg
    44281 ctggaagaaa tctgacagac ttttatccaa tcacagcagg tcttggtcta gttggataca
    44341 acaatggtgc tggtactgtt tatcagccac ttatcggtgc tatgactttg attgtaattc
    44401 taatcttgac aactattcta cttgtattta cacctaatta tgataaagtt atgaccatat
    44461 ctaagaaaaa agggataaag cataaaaagt attctcataa ataacataaa tattgtttct
    44521 attatttaag ttgctagaca gtgaaaagaa aaaatctgtc gtacagtggc tatatgctca
    44581 tgtattcaag aagctacagt tttgattttt cataactgta gcttcttttt gtatttatta
    44641 aatcacgact atcataatac ttgcaatagg tatagtaaca agagagagta ctgtcatatg
    44701 tgttttatat attacattaa gtatattcta aaatatatgt tttaaataat atatttgaaa
    44761 ataggaatat ttaaataaaa aaaataatat tatatatagt tgacaaaaat tggcaaatga
    44821 tatactatat aaatatagaa atagtaatca ttactattat taaaaaggga ggaattaatt
    44881 atgaacttaa aaggaactaa aacagaaaag aatttaatgg caggatttgc aggagagtca
    44941 gaagcaagaa ataaatatac atactacgct tcaaaagcaa gaaaagaagg ttataatcaa
    45001 atagctgcta tatttgaaga aactgctaac aatgaaaagg aacatgctaa attatggttt
    45061 aaacttttac atgatggtat gccttcaaca gaggaaaatt taaaggatgc agcagcaggt
    45121 gaaaactatg aatggactga tatgtatgca aaatttgcta aagaagctag agaagaagga
    45181 tttgacaaga tagcttattt atttgaagct gttggaaaaa tagagaaaga gcatgaagaa
    45241 agatacttaa agcttttaga aaacttaaat gaaggaaaaa tatttaaaag agatgaagaa
    45301 gttgtttggc aatgtcaaaa ctgtggtcat gtgtatgtag gtactgaagc accagaaaaa
    45361 tgcccagtat gtgaccatcc aaaagcatat tttaatataa aagctgaaaa ttattaaaaa
    45421 ttatcattat taaaaaggaa tgttaactat gaaattttct aaacaacgag aactgatttt
    45481 aaatgaaata ttaaataatc cggttcatcc tactgcggat tacctatatg aaaacttaaa
    45541 aaaagataat ccgaatttaa gcttaggaac tgtgtataga aatttagctc agctaacgga
    45601 acatggcttt ataagaaagg ttagtattcc agggtatcca gatagatttg atggtcgaat
    45661 agataatcac tatcatatca tatgtgaagt atgtggagag gtatacgatt tagaatccga
    45721 agttcttaat aatttacaag aattaatatc tgaggagaca gacataaaaa taacatctta
    45781 taacataagt tttaaaggga tttgtaataa ttgtaaaagg tgtagccaag taggttagtt
    45841 ttcaaattct aaaaataatt aatgaggtga gtttatgtgt agtgaacaaa aattttttat
    45901 atgtgagact tgtggaaacc ttgtaggaat gatacaaagt ggtggtgtac ctattttctg
    45961 ttgtggaaaa cctatgaagg aacttgttcc taatacaaca gatgcagcag ttgaaaaaca
    46021 tgtacctgta attgaagtgg atggaaataa tgttactgtt aaagtaagta gcacaactca
    46081 tccaatgact aaagaacatc atatagcatg ggtgtatctt atgactgaac aaggtggtca
    46141 acgcaaatgt ctagcagtag atggagaacc tgtagttaaa tttgctttga atgatgatga
    46201 taaagtgatt tctgcctatg cttactgtaa tttacatgga ttatggaagg ctgaactgta
    46261 atatttaaat aaattgagtc aaaaaggagg ctataaatgt attttcatac aaatagcctc
    46321 ctataaattt atataaattc aagttttaat tttgtttaat gtcaatataa tataaggaga
    46381 aaataatatg tcaatttata aatgtagtgt ttgtggatat atttatgatg aatctaagaa
    46441 tgataaaaca tgggatgaat taagtgaaga ttgggaatgc cctgtatgta caaaaggtcg
    46501 tagttatttt ggaaagataa gtactgttta ctatgaagaa gatgaaaaga tagcagaaga
    46561 catagttgaa gatgaatcta aattaaatac tgaaaaagag ggagatttaa attacttaag
    46621 tacatattta agaagagatg atgaagttga gaaacatatg gatataattc acgaaatggc
    46681 tgttacagga aaatctataa tagaacctat gagaactaaa ctaccagtaa tttcttggga
    46741 tgatatttta attatgggtg ctcaattaaa tccattacct ttaaatgagc atgatgaagt
    46801 aaatacaaca acaataatag gaaaaaaagc aaagaaacct atgattatag aaaatccagt
    46861 ttatatttcc cacatgtcat ttggagcttt gtctaaagaa ctaaaaatag ctttagcaaa
    46921 gggtgcagcc caaaataaga cagctatgtg tagtggtgaa ggaggtatat taccagaaga
    46981 gaaggaagct tcatacaagt atatttttga gtatgtacca aataaatata gtgtaactga
    47041 agaaaatctt aaaaattctg atgctataga gataaaaatt ggtcaaggaa caaaacctgg
    47101 tatgggaggt catcttcctg gcgaaaaagt aactgaagaa atagcaaaag taagaaataa
    47161 gcctgtaggt caagatgtaa taagtccatc ttgttttgag gaaatacaat ccaaagagga
    47221 tttaaagaaa cttgtagatg aacttagaga agtttcagaa gggcgtccaa taggtgttaa
    47281 aatttcagca ggtcatattg aaaaagatat ggaatttata gcttatgcta aacctgattt
    47341 tgtaactatt gatggtcgtg gtggagctac tggagcaagt ccaaagttgc ttaaagatgc
    47401 aacttcaatt ccaacaatat ttgctcttta tcgtgctaga aaatacatag atacacatgg
    47461 attagatata gatttggtta taacaggtgg gcttcgtata tctactgatt ttgctaaggc
    47521 aattgctatg ggggctgatg cagttgctat tgcaagttct gctcttatgg cagcggcgtg
    47581 tcaacaatat cgtatatgtg gttctggtaa gtgtcctgta ggagtagcta ctcaggatga
    47641 ggaattgaga aaaagattac atatagaaaa tagtgctaat agagtggcaa actttttaaa
    47701 tgtaagttta gaagaactta agacttttgc tagaatttct ggtcataaag atatacatga
    47761 tttaagtgtt gatgatttat atactgttaa ctctgaaata tcaaattata caaacataca
    47821 gcatgtatag attgaagttt gaaactatta gattttagac agctataaaa gtaaatgata
    47881 aatatatttt ataaaagaga gtgtcttaaa atgaactttt tagttcataa gtcactcttt
    47941 tttgtatgaa gccaaatata tttatcattt tagcaatgaa aaagaatctt atctctttat
    48001 tttgagatag actccttcta tttatgaaaa ttaaagatat taaattgtaa aatattctgt
    48061 gatgtcgtac tattaaacta aagattctgt actttaaagt aaataaaaat ttaaggagtg
    48121 attattatgg aaagattgaa gatacaagtt ttagtcgaca ataatactta tattgataga
    48181 tactttgttg gagaaccagc agtaagctat tatattgaga ttgatggaaa taggattttg
    48241 tttgactcag ggtattcaga tgtattcata tcaaacgctg aaaaattaaa tatagattta
    48301 ggaaatttaa ctcatgttgt tttttctcat gggcataatg accatacaag aggtatccag
    48361 tttttagaaa ataggtatga tttatctaca gttgaactta tttcacatcc taactgtttt
    48421 atacctagaa aacatggaga gaaaagcata ggagctccat tttctgctga ggaaattaaa
    48481 aatattttta tgtataatcc taaggataag ccatttaatc taagcaagaa ttgtgtgttt
    48541 ttaggtgaaa taccttctat aaatgatttt gaaaaaagag ctaaaattgg taaatgtaaa
    48601 ataggagatt tgtgggaaga tgattatgtt ttagatgatt ctgctatagt ttgtaaaact
    48661 gataaaggta tttttattgt tacaggatgt tctcatagtg gaatttgtaa tatagtagag
    48721 tatgctaaaa aggtatgtgg agatgataga gttattggta tactaggtgg ttttcatctt
    48781 tttgaattga ataataggtt agatagtaca atacaatatt tggataaaga agaaataaga
    48841 atgttgtacc cttgtcactg tgtttctttt aaggtaaaag cgaagatgaa tgaaatattg
    48901 aatataaatg aagttggagt agggctgacc ataagtatat agtatttgaa agtatataag
    48961 atttaagttg aaggttaaaa agatattttc tatagaaaat atcttttttg ttacgtttat
    49021 tttaagagaa atcaatatac ttttatatga aatattgtaa aaaaatttat ttttaatgag
    49081 aatatatttt cattaataaa caattttatt atgtattaat aatgttagaa taaatataaa
    49141 taaatcaaag ttacttacat tacagtatat tttttcacaa aatatattga tttattcttt
    49201 taaagtttga taattccaat gaatgtaata aaagaaggaa ttttatacta tactattatt
    49261 attataaaat aataaagaaa aaattatata ataataaaga aaaaatgtat aatatttaac
    49321 attaaaaaag atatttcata aaattaaaaa acaaagtgaa tttgaatact atttaaaaaa
    49381 taaaataaat atataaaaaa tatttaatat aaaggtagaa ataagttgaa aatgtaaagt
    49441 cattggaaaa atatagttga atttaatgag caaaaatgtt attgttttat caataaagtg
    49501 ttaaaataaa aacttttaat atcattttag ggaggatgat ttcatgcaaa aaagtgtaaa
    49561 gaaagcaaaa gtaacgggct ctatgttagc catttttggt gttgcaagcg ttctttttag
    49621 ttcacatgca ggaggaggat ttgctacagg gaatcaagaa actcagtact atgtgcagta
    49681 tggatggaca gcaccactta tggcaatttt agcaatgatt atacttactg ctaccatgag
    49741 agaagttatc ataatgtata ataataacaa ttgtaggaat tataaggatt tattttgtga
    49801 gctttggaga ccatatccaa aacttgaaat aatatgggag atatattact atctaatggt
    49861 tttaatagct gtaagtgctg ttatagcagg tgcagcagca gtatttcaaa gtataggagt
    49921 aaattatttt gtagctgtat ttattattgg agttgtactt cttgtcttta ctatatttgg
    49981 tgctatgctt gtatctaaag cagctacagc aatgacaata gctattctag tatgtactct
    50041 tactattttt attgttggta taaaagctaa agtaccagaa ataactgaaa tattatcaaa
    50101 tagaacgagt ttcacacctg gctatatcaa gccaatactt aatactttta tttatgcagg
    50161 ttttcaatcg gttgttatac ctacacttgc aggatgttca agaccacttc ttaagaactc
    50221 aaaagaagct actaaggcaa tgataatttc atttgttatg aatgcaattg cattaggact
    50281 tgctgtaact atgctaatgg gatggtatag agaaattatt gctgctgggc aaacaacact
    50341 ccctactctt tatgttgcag gtcaatctgg aaatcatact atatacataa tttataatgt
    50401 tgcattattc ctttgtttaa tgtctacagg agtaactact atatttggtc ttgtaaatag
    50461 atttgaagac cataaagcac tttctttcct ttcttcaaga atgaaaagaa gggtatttac
    50521 agcttgtgca ataatggtag tgtcaatgct tatatcactt acaggattaa gtaatattgt
    50581 taaatatgga tatggatatt gtggttatct tggtctattc actatagtaa ttccattcct
    50641 tacactagga cattataaga ataagaagtt tgcaaaggaa aatccagaag ctaaatggcc
    50701 agcggaatta aatgaaaatg taaattagat gtagtagcaa aaaatattgc taaagagaat
    50761 actatagata agaatactat agataatata tctgcatgtt tattaagatt atttgcaaaa
    50821 tctaatatta aacaactata aacaagcaat ataaaactaa gaataaaaga taaaaagagg
    50881 gtgtctcaaa atggactttt agtttataag gcactctttt ttatatgaag tcaaatatat
    50941 tttcattatt ttgacaataa aagagactaa tcctactttg gatagcctct tttttcttta
    51001 atataaaata gtataacagc aaagtataga ttgatacatg ttttctgtag ctttctatat
    51061 attacagtgt ttgtgtggca ttggtatttt aagcaatcta taaattataa ttctataatt
    51121 cttctactaa ttttagattc tatagccgtc tctatttcac ttaacattcg ttcattttta
    51181 gggtcaataa aagcacatgt atagccttct tcaccagctc taccagttct accaatacgg
    51241 tggatgtagt cttctggtgt ttctggtaaa tcgtaattat atatatgact tactccagat
    51301 atatcaagac cacgagaagc tacatctgta gctattaagt attgtatatc taaatttcta
    51361 aatgatttca ttattctttc tcgttttgat tgagcaatat cactatgaag tttttgacaa
    51421 ttatatcctc ttatagcaag agcttcttca agattgtcaa cccttctctt agttctacaa
    51481 aatattattg ccataaaagg attatcttca tctagtacct tacataaggc atctaatttt
    51541 tttctatctg tagtttctac tacttcttgt tttatattat taagagtgat ttcttctttt
    51601 tgaatagaaa ctacaacagg attttttgtg tatctataag ctaatttttt tacttgagaa
    51661 tttatagttg cagaaaagca tagtgtttgc tttttgtttg aagtctcttt taaaatagct
    51721 tccacttcat ttttaaatcc cataagcaac atttggtctg cttcatctaa aacaaaagtc
    51781 tttaacttac taaggtctat tgtttttcta tttagatggt ctaaaagcct acctggtgta
    51841 gctataatca tatgaatatt tccttttagt ttctttattt gagaaccaat atcttttcct
    51901 ccatatgctg caagaatact tacatcttta gattctttaa gtttcatagc ttcttctgtt
    51961 atttgaatag ctagttctct tgtaggagaa agtataagta cttgtatatc atttatatct
    52021 aatgatatat tttcaaatat cggaagtaaa aaagctagtg tttttcctgt tccagtttga
    52081 gcttctgcta ttacatcttt tccttctttt attagtttaa tactttcttt ttgtataggt
    52141 gtaggtgttg ttattcctga tttttttaga atatttattg tattttcact aatccctaag
    52201 cttttgaaat ccattgttat cttacctttc atgaaaaatt ttctttttta ttaaccaatt
    52261 aataatatca tatttataag tatttttagt aaatttttta attattattt atatagctta
    52321 aaaatatatt aagatacttt aaaatggaat gtaacttaaa ttaaatttta gtaggaattt
    52381 tataggttta tttttaaagg ttttttgaaa ataaatctat ttaaaaatta aattaaaatg
    52441 caagaaaaac ataataactt tcatttttaa gaagttttca caaaaaagaa aaaatatagt
    52501 gcaataaatg atacaaagta atataataga ttacaagata tgaaaagcta aaaaaataaa
    52561 ttgcaaatga aattaaaatg aataaaaaat aaaaaaataa tcataagtta gaggtatcaa
    52621 tgaaaaataa gacttaatgt tttaaaatta aaagtatact aaggggggca ttaatatgtg
    52681 cgttatatca aaagatagag caaaggaaat aaaaatagta gatactactt taagagatgg
    52741 agagcaaaca gctggggttg tatttgcaaa tagagaaaaa ataatgattg ctgaaatgtt
    52801 aagtgaccta ggtgttgacc aaattgaagt tggtatacct actatgggtg gagatgaaaa
    52861 aaatgtaata aagcacatat gtagtagaaa tttaaaatca gatataatgg cttggaatag
    52921 agcagtaata aaagatgttg aagaatctat ttcttgtggt gttgatgcag tagctatatc
    52981 aatatcagta tctgacattc atatagaaaa taaattgaga acttctagag gctgggtttt
    53041 agaaaatatg gctaaaacag ttgaatttgc aaagaaaaat ggattatatg tttcagtaaa
    53101 tggagaagat gcttcaagag cagatataga cttcttaact gaatttataa atgttggaaa
    53161 acaagcaggg gcagatagat ttagatactg tgatacagta ggagttatga atcctttttc
    53221 tataaagaat gcaatagaaa ctctttatga aagaactaat tttgatatag aaatgcatac
    53281 acataatgac tttgggatgg caactgcaaa tgcacttgca ggaatagcag caggagcaaa
    53341 ttatgttggt gttacagtaa atggattagg tgaaagagca ggaaatgcag cattagaaga
    53401 agttttaatg gcacttaagt gtgtttataa atgtgattta aataatatag atactagaaa
    53461 atttagagga atatgtgagt atgtagcaca ggcatcagga agaatacttc ctacatggaa
    53521 accagtagtt ggggataata tgtttataca tgaatctggt atacatgcag atggagcttt
    53581 aaaagaccca cataactatg aaccatttga cccaagtgaa gtaaatcttg aaagaaaaat
    53641 agtaataggt aaacattcag gaagagctgc agttgtaaat aagttgagtg aatatgaaat
    53701 gtatatttct ccagaaaacg ctaccaagct attaaatgct ataagagcta catctataag
    53761 attaaaaaga agtttaatgg ataaagaaat tcttcaatta tattgtgata tactagcaca
    53821 tgagaaaggc acaacagaag aagaagcagt tagaggttca tatatttaag atataattgt
    53881 ttaggaggaa aatatgggag ataatatagt ttataaaata attaaaaaac atatagtaga
    53941 tggagaagct gttgctggaa gttcaattgg tataaaaata gaccaaactt taacacaaga
    54001 ttctactgga acaatgacat atcttcaact agaagctatg ggaatagata aagtaaagac
    54061 taaaagaagt gtggcatttg tagaccataa tatgttacaa caaggatttg aaaatgcaga
    54121 cgaccataag tatatacaaa cagtggcaga taaatatgga gtttatttct ctaagccagg
    54181 aaatggtatt tgtcatcaag tatttttaga aagattttca acaccaggag atacactttt
    54241 aggttctgat agccacacac ctactgctgg aggtgtgggc atgatggcta ttggagctgg
    54301 tggattagat gttgctttag ccatggcagg aggagcatac tatataaaag caccaaaagt
    54361 ctgtaaggtg aatctagttg gaaaattaaa taatatggta tcatcaaaag atataatatt
    54421 agaagtgtta agaaaacaaa ctgtaaaagg tggagtaggt aaagtttatg aatatggtgg
    54481 agaaggtgtc aaaagcctat ctgttccaca aagagctaca ataacaaata tgggggctga
    54541 acttggagca actacttcaa tcttcccaag tgatgaaaaa acactagaat tttttaagag
    54601 tcaaggaaga gaagaggcat ggatagagct aaaaccagat gcagatgcag tttatgatga
    54661 agagattact ataaacttgg atgaattaaa accattagct gcaaaacctc atagcccaga
    54721 caatgtagat gaagttgaaa atataggcaa gattaaaata gaccaagtgg caataggaag
    54781 ttgtacaaat tcttcttatg aagacttaat gaaagtagca caaatcctga aaggaaataa
    54841 agtacataag gatgtgagtt tggtaatagc accaggttca agacaagtta tggagatgat
    54901 tgctagaaat ggggctttgg cagatataat aagtgctgga gctagaatac tagaaaattc
    54961 ttgtggtcca tgtattggta tgggtcaatc tccaggtact gactctgtgt ctttaagaac
    55021 tttcaataga aatttctatg gtagaagtgg gactttgtca gcacaagtat atttagtaag
    55081 tccagaagtg gcagcagtaa gtgcaatcaa gggagtgctt acagacccaa gagaatttga
    55141 tattaaattt acaaatttag atgtaaatga atttttgata gatgatagca tgataattaa
    55201 acctgctgat gtaggaagtg atgtagaagt agttagagga cctaatataa aacctttccc
    55261 tcttaataca gagctaagtc agtctatagg tggaaaagtt atattaaaga cagaagataa
    55321 tataactact gaccatataa tgccatcaaa tgctaagtta cttcctttta gaagtaatat
    55381 accgtatctt gcaaactatt gtttcaatac tgtagataca gaatttcctc agagagcaaa
    55441 agacaataat ggtggattta tagttggtgg agataattat ggtcaaggtt caagtagaga
    55501 acatgcagct ttagcaccat tatatctagg tgttaaaggg gtaatagtta agagctttgc
    55561 aagaatccac aaggctaact tgataaatag tggtataatt ccaatggagt tttgtgatga
    55621 gaaagattat gaaaatatat ctcttttaga taatctggag ataccaaata ttttagacaa
    55681 tctaggtagt ggaattttag aagttaagaa tacaactaaa ggaacttctt ttaaggtcaa
    55741 agtagaattg tcagcaaaag aagttgatgt attaaaagct ggtggaaaat taaactacac
    55801 taaaaatcaa gctaattaat atgaaaagag ggaatattga atgtataaag tgacacttat
    55861 accaggagat ggaataggac cagaagttgc gaaagctatg aaaaaggtag tagaagctac
    55921 tggagtagaa atagaatggg aagaagttaa tgcaggagag gcagttattg aagagtatgg
    55981 tactccactt cctgaatata ttatagatag tataaaaaag aacaaaatag ctataaaagg
    56041 cccaattact actcctgtag gtaaaggatt taggagtgta aatgtaactt taagacaggc
    56101 attagatttg tatgtcaatt taagacctat taaaagtttt aaggggataa aatcaagata
    56161 tgaagatgtt gatttagtgg ttgtaagaga aaatacagaa gatttatatg ctggaataga
    56221 acataaaata ggtgattatg cagctgaaag tataaagata ataacaagaa gtgcaagtga
    56281 aagaatcgtt gattttgcat gtaactatgt taaagataat aagagaaaaa aagttacagc
    56341 tatacataag gcaaatataa tgaaaatgtc tgatggattg tttttagatg tgtttagaga
    56401 agttgcatca aaacatggtg tagaatatga tgatttgatt gtagatgcag cagctatgaa
    56461 cttagtttta aatccagaaa attatgatgt aatggtaatg ccaaatcttt atggagatat
    56521 actatcagat ttaggtgctg ggcttgttgg aggtttaggt ataattccaa gtgcaaatat
    56581 tggtaaagat tgtgcgatat ttgaagctgt tcatggaagt gctccacaaa tagcaggtca
    56641 aaataaggct aatccaacag cacttattca atcatcagta atgatgctta gatacttagg
    56701 tgaatatgaa aatgcacaaa aaatagaaac agctttagaa aaagtatttc ttgaaggaag
    56761 taaattgact gtagatttgg gtggctcagc ttctactaca gagtttgcgg atgaggtgtg
    56821 taagtatatt gtatagattt tatttaggga aaaagtaaaa tatagattga aggaaagagg
    56881 ctttctcaaa atagagataa gcctttttta ttggaatgat aaaatatatt tgattttata
    56941 caaaagagag ttcctcataa acgaaaaagt taattttggg atatccattt taattttaaa
    57001 attaattgat taatatgcaa agaaagatta aataaattta ttatttttaa ttgaactttc
    57061 aaccaaaata tggtaaaatt taaaaaagtt gaactttcaa ctaaaaatga atatattgat
    57121 tatgtgaaat tttataaaac agaaactatt tgactttagc catagtagtt tcagtggagg
    57181 tgtgtttgat taagacttta gatagtaata tattaagaga agtaggtact ttatctagag
    57241 cagtaaattc aataaatgat attaagtaca aggaattaaa gttacaaaaa ggacaattta
    57301 catttttgac aagaatctgt gaaaatcctg gtataaatct tgtggaatta tcaaatatgt
    57361 taaaggtaga caaggctaca acaaccaagg ctatacaaaa attaataaag gcaggatatg
    57421 tagataaaaa gcaggataag tttgataaaa gaggatataa tttaactcca actgataaat
    57481 ctttggaagt ttatgagttg ataattgaag aagagaatag aagtatagag atatgttttg
    57541 ataattttac agatgaagaa aaacaagtgg taactaagtt attagaaaaa atgagcaaaa
    57601 acgtagaaaa tgaatggttt aaagtaaaga gatagtaaat aaatacatta acttaaggag
    57661 atatttttat gattagaaaa gcgaatatga atgatttaga aagcattatg caaattataa
    57721 aatctacagt ggaagaaatg aagacttata ataatacaca atgggatgaa aactatccat
    57781 tagaaaaaga ctttgtttca gatattaaga aacaagattt atatatttat gaagtggatg
    57841 gagaagtagc agggtttata tgtcttaatt atgaagagcc agaagaatat ttaggcttaa
    57901 attggtcatc taataaaaaa gcaatggtaa tacatagaat ggctgtaaat ccaaacttta
    57961 gaaagacagg aatagcatct aagttagttg attttgctga aaaattagct gtagaaaaca
    58021 atgtatcata cttaaagagc gatacatatt caataaactc aaaaatgaat ttattactta
    58081 caaagtgtgg ttttataaaa atcggagaaa tgagtttttt aggaaaggag aaatctttct
    58141 actgttatga taaaatatta taaagagcat ttataataca agggataaat aatagatttt
    58201 cagcattagt aagggcataa tataacctag tgtatgctat tatgaaaggg atgatttata
    58261 tgattggatt tctaaagaaa agaagaagta ttagaaaata caaggatgtt gaagtagaaa
    58321 aagaaaaatt agataaaata ttaaaagctg ctcttttagc tccatcatca aaggggctta
    58381 gaacatggga atttatagtg gtagatgata aagaaaagct aattaattta tctcaatgta
    58441 gaactaaagg tggtggattt ttcttaaaaa atgcaccttt agctattgta attattgcag
    58501 ataaagaaaa aaatgatgtt tggatagagg atgcaagtat agctgcttca tacatacaac
    58561 ttcaagctca tgaactaggt ttaggttctt gttggataca agtaagaaat agaatgcatg
    58621 atgataatat agaagctgat aagtacatta gagaagaatt aaaagtacct agcaagtaca
    58681 gtgtagaatg tataatttct ataggatatc ctgatgaaga aaagaaagca tacggtgact
    58741 ctgatttaga ctataaaaag gttcatttta acaactttta gtatataata tgttgtatta
    58801 agacattata tttttttcta ttgttaatat atacttaaaa ttgtaaaaat atatctgaat
    58861 tttactaact tatctagggg ttatgtacaa ggattttaaa gataaatata gaaattaatg
    58921 tttataatcg atacataact tgagtaacaa aatttaagga ggttaaagta tgggtatatt
    58981 taaaacaaaa atggatgagg actggaaagt aaactacatt aaagagttta atgaaatgag
    59041 agattcttat gagagtaaac ttcaaaaaaa acagtttgag gtagatagtt tgaaatcaga
    59101 attggataga ctaagaagct ataaaaatag ccttaagcca aaagaaaaac aaattactga
    59161 tgatgatata aataatataa agagtttaag aagagatggc ttaagctata aagaaatttc
    59221 aaatcaaaca agttggagca aagcaactgt aagtagggta ttaaatggac tttacgatta
    59281 gcatatacat ggggtgattt aaattgggat gaagtatagt tacaaaaaat gcataataga
    59341 ttctatttta ttgatgttta tagttcaaat attaaggatg attttgaatt atgtacttct
    59401 aagtcaattt gaatttactc ttgaaaattt taatattata aacttaattt cttttacatt
    59461 agttggttta tcgttaattt tatttttaaa agataattct ttgtataaca aggttagaaa
    59521 tagaaaaatc acagaagctt ttgaagaaaa taaaaacaat atacttattg aaaagtgtaa
    59581 gctgatactt tttgttgtgg ttttatcttt agcaataatt gtaacttatt gtactaaggg
    59641 atatgtactt tttaatgtaa ctatgatgac tttgtctgta ttgatagtcc caatatttga
    59701 agagttattt tttagagaat atatatggaa ctatctaagt aattttataa agtcaaagag
    59761 taaaattatc tgtataacat ctatactatc tggaatttat aatataggat acatagatgt
    59821 tataagaaat tatgtaatat tgtataacaa ttcaagctac acctttgaag ttattatttc
    59881 aaaaattatg ataggtactg tttttggtat tgtacttgga ttagttaagt ataggtttag
    59941 agatgtaggg ttttgtatat tattgaggag cttatttgct atatttatta ggtagatagt
    60001 ataatcggtt tataaggttg ttttaaattt aattttaaat caaccttatt ttatttgtgt
    60061 tttat
//
LOCUS       DAEPID010000016        56798 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.016, whole genome shotgun sequence.
ACCESSION   DAEPID010000016 DAEPID010000000
VERSION     DAEPID010000016.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 56798)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 56798)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..56798
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.016"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            complement(122..961)
                     /locus_tag="KR257_001123"
     CDS             complement(122..961)
                     /locus_tag="KR257_001123"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860838.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS system mannose/fructose/sorbose family
                     transporter subunit IID"
                     /protein_id="HBH0029842.1"
                     /translation="MSDIKNEVSKKTLSKKDVIKSWLRWFFFAQSNYNYERLQSTAFS
                     HSMLPVLKKLYPDKEELKQEVETHLAFFNTEPICGCVIHGITIAMEEEKANGADEISG
                     DGMNAIKTGLMGPLAGIGDTLTQGVITPIVLAVCIGLTEGGASIAGPILFVIAQYIIM
                     TSISFGMWTNGYKYGKKAVESILQGGIVNKVIEGASILGTLVMGGLVGRFINLSTPIS
                     YTSGDFKFSLQTDLLDKIFPGLIPLVLTLLVLFALKKGLSPIKIMFILIVVGAITGIL
                     GLF"
     gene            complement(985..1743)
                     /locus_tag="KR257_001124"
     CDS             complement(985..1743)
                     /locus_tag="KR257_001124"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895533.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIC"
                     /protein_id="HBH0029843.1"
                     /translation="MHISLIQAVLIAIFYYLSWSPWLTYVGFFTWNRPLLAGFVTGII
                     LGDPVQGAIIGAGINMIYLGFISAGGAQMGDPAFAGYVGTALAIASKLDVSTAMAIAV
                     PLGTVATVLWIGKMTVNSFFAHWADREVQKGNVDRVAFINIVPPQILLFAMSFIPALL
                     VVYFGPNAIDGMLEVMNDNVLHVFNVIGAMLPALGIAMNLKLIGNKFTMPFFILGILM
                     AVYFKVDIIVISVIGVILALTITSIKYGKDSATS"
     gene            complement(1790..2263)
                     /locus_tag="KR257_001125"
     CDS             complement(1790..2263)
                     /locus_tag="KR257_001125"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888320.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIB"
                     /protein_id="HBH0029844.1"
                     /translation="MSNIALTRIDDRLIHGQVITAWCKITSAKRIVIVDDLVVKDPFI
                     VQVLQMAAPSTVKVEVHDVESGAEVLKSYNGDENLIVLVKYPKTVLGLVNSGVDLKEL
                     NVGGMGAGLGRKSFYKNISVSDEEKEIFRELISKDVKCFIQIVPDAKKIDVGTLL"
     gene            complement(2292..2708)
                     /locus_tag="KR257_001126"
     CDS             complement(2292..2708)
                     /locus_tag="KR257_001126"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426358.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIA"
                     /protein_id="HBH0029845.1"
                     /translation="MIHMAGIIIATHGNMAKAMLESAELIVGKQENVETLGLNHGDSI
                     DEFSRKLEDGIEKYKDEGVLVLLDFYGGTPFNTSAIIINKFAKVCELECLTGVNLPML
                     LELFLNRDTMKLKDLKNLCEEVGISGIKDVKTVLKL"
     gene            complement(2755..3807)
                     /locus_tag="KR257_001127"
     CDS             complement(2755..3807)
                     /locus_tag="KR257_001127"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426357.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="galactitol-1-phosphate 5-dehydrogenase"
                     /protein_id="HBH0029846.1"
                     /translation="MKSVRFYGIRDTRVEDVDVPKILEKDDVIIKVKVAGICGSDISK
                     YSKTGPHMVGEILGHEFSGEVAQVGKEVRSFKIGDRVAVCPAMPCFECDECKKGLYSR
                     CNNVAIIGNKELGGCFAEYTKVKERNLIKIPDEISYETAAALEPVCIAGHGLFRSEAK
                     VGDTVVVLGTGPIGLFSIQWAKIFGSTKIIAVDVFDEKLDLAKELGADICINAKEKNI
                     VEEIKRLTDGDGADIVIESAGTPLTCGQVLLLAKKGGTVLYAGVPYGDVALTREQFEK
                     IVRSELTVKGTWFGNSFPFPGKEWSAGLYHMQKGDMNVEKLVTHRINLEEVPAYFEKV
                     YKRDIFFGKIMINIDN"
     gene            4203..4883
                     /locus_tag="KR257_001128"
     CDS             4203..4883
                     /locus_tag="KR257_001128"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426355.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphoribosylaminoimidazolesuccinocarboxamide
                     synthase"
                     /protein_id="HBH0029847.1"
                     /translation="MKKVYQGKTKDVFELDNGNYLLKFKDDVTGKDGVFDPGENSVGL
                     SIDGIGRANLETSVKFFEILNNAGIKTHYVSANLEEATMEVLPAKVFGNGLEVICRYR
                     AVGSFLRRYGSCVEEGAKLDCYVEATLKDDDRCDPLITSEGLEALNIMTQAQFDSMKS
                     MTQKISNIVRDTIAEKGLELYDIKFEFGFYNDEVILIDEIASGNMRVYKDGVIVDPMD
                     LTALLLDK"
     gene            complement(5016..5336)
                     /gene="sugE"
                     /locus_tag="KR257_001129"
     CDS             complement(5016..5336)
                     /gene="sugE"
                     /locus_tag="KR257_001129"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000118520.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="quaternary ammonium compound efflux SMR
                     transporter SugE"
                     /protein_id="HBH0029848.1"
                     /translation="MKWLFLFVAGLFEVFWAFQLKNSHGFSKLTPSILTVVGMIVSFY
                     FLSLALKHLPLGTSYAIWTGIGTVGTAIVGMAILNEPISISRIACIGFIVVGIVGLKL
                     LSTN"
     gene            5718..6545
                     /locus_tag="KR257_001130"
     CDS             5718..6545
                     /locus_tag="KR257_001130"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434776.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="carbon-nitrogen hydrolase family protein"
                     /protein_id="HBH0029849.1"
                     /translation="MNFYKIAVCQMITTENKIENINHAVDMVTEAAINGSKIVVLPEM
                     FNCPYENKYFPKFAEEYPGETTTILSKLAEKHGIYLVSGSIPELEDGKIYNTCYVFDK
                     NGALIGKHRKMHLFDIEVTGKVSFKESDTLTAGNDVTVIDTEYGKVGIAICYDIRFPE
                     LSRLMALKGAEIVILPAAFNMTTGPAHWELSIRMRALDNQIFYVGAAPARNMNASYIA
                     FGNSRISDPWGRIIAQADEKECIIYADIDRDLIPDIRQQLPLLKHRRTDLYELNTLK"
     gene            7367..8041
                     /locus_tag="KR257_001131"
     CDS             7367..8041
                     /locus_tag="KR257_001131"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003417819.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HBH0029850.1"
                     /translation="MNNKILVVDDEEGIITLLKDYFEMNGYEVYTAQSGKGALKKISK
                     NPDIILLDINMPEIDGIEVCNRIRDYVSCPILFLTARIENTDKINGFRAGADDYIVKP
                     FDLDELGARVSAHLRREKRKSNQTKIKFYNDLTIDYEKRLICIDNNQISLSKKEFDIV
                     ELLSMNPGQVFDKEKIYDRVWGYNSNGNSDVIMEHIRKIRIKLSKHTLENYIETVWGV
                     GYKWIK"
     gene            8029..9189
                     /locus_tag="KR257_001132"
     CDS             8029..9189
                     /locus_tag="KR257_001132"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728740.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sensor histidine kinase"
                     /protein_id="HBH0029851.1"
                     /translation="MDKINNMSLKKAFFVLTLSSLIIASTLTTFSYILLNNLYNSIQD
                     KYLKTPINTGFITIVQNNVNQFSDYDKTLLNIINILQLVLPLIFFIGLLLLADIIFYK
                     VKLKTPIEILNKGAMEISNNNLDFCLEYNNNDELGNLCNAFEKMRSELNKNNIKMWTM
                     INDRKQLNAAFSHDLRNPLTVLKGYSNYLTKYIPTGKLSDEKILSTTQLMSEHINRIE
                     YYVENMSNAQRLEDLVVSKSMSNINKFIENLDENISIIAKQEGKSFTLKSQINNINLF
                     FDENIILRVVENIISNAFRYARNNVSILIYLEQELLTFVIEDDGIGFSKESLKLALRP
                     FYRDKTLNDSNAHFGMGLYISKILCEKHGGSISIENNSTNSAKITAKFSTRN"
     gene            9460..9933
                     /locus_tag="KR257_001133"
     CDS             9460..9933
                     /locus_tag="KR257_001133"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728741.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CDP-alcohol phosphatidyltransferase family
                     protein"
                     /protein_id="HBH0029852.1"
                     /translation="MLSFTFCSLPFWICYFWCGISDIFDGLIARKLRQQSGIGAKLDS
                     IADFIFSVTILVTVGKNIALPMYLWWCIVAIALLRLISYSIGFFKYRTFSSLHTLMNK
                     ITGISIFAFPLLYICFGLDVAGIMICIVAFLSSFEEIAIMIKSKELNRDIKSIFM"
     gene            10219..10887
                     /locus_tag="KR257_001134"
     CDS             10219..10887
                     /locus_tag="KR257_001134"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895525.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBH0029853.1"
                     /translation="MIIKAKQLSKIYGSNNNKVIALNNVNLEINSGEFVSVIGPSGSG
                     KSTLLHILSGLDNPTSGQVLLDDKDIYKHTEKELSALRRKSFGFVFQQFNLLPVLTAS
                     ENISMPVLLDKKQPDKEYLNEISSLLGIADRLNHLPHELSGGQQQRVAIARALIAKPD
                     IIFADEPTGNLDSKSGSEVMNLLIKTSKQFGKTLVVITHDDRIAKLADRKISIIDGVL
                     MEVK"
     gene            10890..13358
                     /locus_tag="KR257_001135"
     CDS             10890..13358
                     /locus_tag="KR257_001135"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860832.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBH0029854.1"
                     /translation="MKNYLSLSIKELKSQKLMTTFIIIAIVLSTIMTTVVGQSIGILQ
                     NLRIEQARSFNGDRHVSFHQLTKNQVDDIKKDDRVYQAGTSITLGSSKIKDSGISVLV
                     KEYDKTGLSNYPKLMKLKSGNLPKDKNEIALDENTLKLMGIKPRLGVTIPMNLDISLL
                     NDTIPPYNYTANFKLSGILEDDYTGYVSGIVNGIVGKGASENLLPKRYILSSLDFKIK
                     QQEKFQEIVNQLAKKINLSHNSIQYNWIYLNALKIQFEKDENSSNSDGISMIILVSLF
                     VALLVLLASGLVIYNILKISVTKKIKEYGCLRAIGAEPNQIYKIVILQILILCTIAIP
                     IGAVIGIISSKGITGMVTNILNPDILLANDNKEITELIHKNTTAYIFPLVLSTSISLI
                     FSLISALPSAIYASHVSPKIAMAGSTTKIKRKIKREKTIKNFERHLAWLNLKRNKGRT
                     IITILSLFMSITVFVALSEFSNVLDVSRSVSNLKEGDFSLTNEISGFDKSILDKIDKM
                     KNVNRTSFIKYSEYKQGEIDTDINFENSGEMLKIIGIDEQTLKDLMPSITDSILEDFK
                     NGSICFIKNPIAISTPGVKTRHTNLKPKDNITINKKQLDIYSTVDKMFFLQGNGWING
                     VDVIVYDSVYNTLTNKNKFNQINIYAKDKSKLEQIRLSIEQICENNPGSHWISYIESD
                     KQLKESFKQIEFLAWAVILFVGLIGTLNIINTTHTNINTRTNEIGVKRAIGMSNSSLY
                     KMFLWEGVYYGIFATIFGSIAGYVSAIIINMATIEKLDFTNIPITSILQATIISILAC
                     IIATLIPLRKVKKMNIIDCIDVNL"
     gene            complement(13597..15021)
                     /locus_tag="KR257_001136"
     CDS             complement(13597..15021)
                     /locus_tag="KR257_001136"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895522.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HAMP domain-containing histidine kinase"
                     /protein_id="HBH0029855.1"
                     /translation="MKNQSLITQFRHTFIFIIIASIVATVITYVFALYLYIHSLNKDI
                     YPPNYYERQVPRIEKYINEKNITLLSQSNEEGLKRTIRGDDMLYQVVDNNGNILYGTN
                     PKKLFKTKEELFNNFINKTVRKGGYIHTVPIKGDNGKIEGAVILFYQVKITFANIRGR
                     FVFAVIIMALFSPFLYIVGFTRWLSKRFVKNINQPLHLLIDASKKIKEKDLDFEIDYY
                     SDNELGKLCSAFSEMKDELKGSLSAQWKMEQERVEMVEALAHDLKSPLSIILGYTDAL
                     IGNNTDDNEKLHRYLTVIRENTEKSAALVQKMQYTSDLEKSNIQLNLVPINLPEFLRQ
                     KVQDYELQAHQKEVELILKMQGNIQSPIQIDVDRLTRIFDNIISNSLQYTPSGGNISI
                     TVKDEKNCISYEICDSGRGFSSKDLKKALDKFYRGDEARQTKGGHSGLGLYIVKQLVE
                     QLGGSVKIENSKSGGACVKFWHSI"
     gene            complement(15040..15732)
                     /locus_tag="KR257_001137"
     CDS             complement(15040..15732)
                     /locus_tag="KR257_001137"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003417590.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HBH0029856.1"
                     /translation="MSKILIIDDEMDLVMLLEDELKAKGHEVLIAYDGQAGIELSKQE
                     PDLIILDIMMPKMNGFEVCQAIRDDVLCPIIFLSAKQSETDKIKGLTFGGDDYVTKPF
                     GLRELMARIEANLRREKRSQYINEENKRSTLYFGKLCLYMKERAIKIDGKNIDLTKIE
                     YDIVELLALHAGQVFSREQIYEKVWGCDSEGDSSTVVERVKKIRAKFSAVTPEKEYIS
                     TVWGIGYKWNKM"
     gene            complement(15787..16563)
                     /locus_tag="KR257_001138"
     CDS             complement(15787..16563)
                     /locus_tag="KR257_001138"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434743.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="lantibiotic immunity ABC transporter MutG family
                     permease subunit"
                     /protein_id="HBH0029857.1"
                     /translation="MIKLLSSEWLRAKRTAVQWLTLFMPIIFSLCVVFYLTTKSGSTQ
                     EFAFEGFFTVWTVFIIPIGVGILAGFIVQEEELAGNFNGFLCVGISRVRLYLGKFLFL
                     LFCLTICTFIATLILCIGMSIAVPSGATIWLFLSAAGLVVIGTLPLLAIHLWVSFAWG
                     MGASIGISIGGILMAAILGLTSVGEKVWAFVPWTWPVKLGMLPGIYFIKEAGTISTEA
                     FYSKVMQTASIELIVVAIGLIIFLIGGVIWFKMWEGRKSY"
     gene            complement(16560..17330)
                     /locus_tag="KR257_001139"
     CDS             complement(16560..17330)
                     /locus_tag="KR257_001139"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888312.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="lantibiotic immunity ABC transporter MutE/EpiE
                     family permease subunit"
                     /protein_id="HBH0029858.1"
                     /translation="MNALQSELLKYKRTFMGKLIVFFPVSFAAYAFIMQSTLMQNPLS
                     QTTSWAWQSLLALIFNWWSFLFLPIGFALFATLVAFQEKKAGNYRALRTHNVSPMTLW
                     INKVIAMAVYSFISTLVLIVVTIITGLILKAGPVPFGQIIGASIVCWVVSLAILPLQL
                     WLATWKGMFLSMGVGALGMIFGVLAATKPFWIAVPWSWAVRMVCPIINIHPNGTILEA
                     GDPLLNTSVIPIGIVVSLVVFIVLTALTAAWFNRRDDK"
     gene            complement(17327..18031)
                     /locus_tag="KR257_001140"
     CDS             complement(17327..18031)
                     /locus_tag="KR257_001140"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014466355.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="lantibiotic protection ABC transporter
                     ATP-binding protein"
                     /protein_id="HBH0029859.1"
                     /translation="MKDLILETKNLSKRYGEQMAVNNVSLQIERNSIYGLLGPNGAGK
                     STTLKMLVGLLRPTNGRIIFDRKPWKRESLAKIGSLIESPALYGNLTAEENLLVHTKI
                     LGIPKDKIYEVLEIVNLKNTGKKRASQFSMGMKQRLGIAIALLSDPELLILDEPTNGL
                     DPFGIQELRELIASFPKKGITVILSSHILSEVAQVVDNIGIINGGRLLFQGMPDPNEN
                     LEEFFTDVILKGGQNR"
     gene            complement(18286..18798)
                     /locus_tag="KR257_001141"
     CDS             complement(18286..18798)
                     /locus_tag="KR257_001141"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860830.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0029860.1"
                     /translation="MKKISQEKISTHIQEVPQEKIEQWKSLYEKYKSILKVNSKSVLE
                     IIEFLKRKYVIVEETSEEFKHVVINNIKLNKPFSQKISSDKELKPIVFTIPNEGNAKK
                     LYDTQEEIYSGCKIIVGMEFETGYVFVEGSDELNDEITSFKGLDKYDINNYYLVANYI
                     RCLKKYKLID"
     gene            19124..19381
                     /locus_tag="KR257_001142"
     CDS             19124..19381
                     /locus_tag="KR257_001142"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426325.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0029861.1"
                     /translation="MILNRAELFRGYSLNRFNEICNILSVNKIKYKYKVKNNAYSKKP
                     FFNEITLGNLGQKEDFSYEYLIYVHKDDYEQAESLINSKLR"
     gene            19524..20150
                     /locus_tag="KR257_001143"
     CDS             19524..20150
                     /locus_tag="KR257_001143"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426324.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="uracil-DNA glycosylase family protein"
                     /protein_id="HBH0029862.1"
                     /translation="MKINIKSKLSEFIKQNNLFDDSRIISYLPNITIETDKIKTIMIN
                     EVVPTNTNDDFYSVDKDADYLKTTIPLFDSAGIKVSNINDILDMGIYITNAVKLPKSE
                     YTITRDTIKLHMPILEEEIKLFKNLEVVMLMGDVAKKSFNMITKKHIKKNVIPSISTY
                     KLRNNELYYDNLRVFPSYIMTGGNILIEKSKFEMASEDIKKMFEIING"
     gene            complement(20397..21176)
                     /locus_tag="KR257_001144"
     CDS             complement(20397..21176)
                     /locus_tag="KR257_001144"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009901940.1"
                     /note="N-terminal region resembles flavodoxins. C-terminal
                     ferrodoxin region binds two 4Fe-4S clusters; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="EFR1 family ferrodoxin"
                     /protein_id="HBH0029863.1"
                     /translation="MNSKIYYFSGTGNSLVVSNILKETLNGSKEVIPLAIHRKENNID
                     INEDILVIVFPVYFADVPDIVKSFVEKLNFNINTHIYAIATCNGVAGHSLFTIDKLLK
                     KRGKKLSAGFLINMPGNALITPPDVEEERLKNQTNRVAEIAKCINNLEIGNIEGKNNL
                     KSHIDSVVLRLVGKNMQIATTKFFAENKCNRCGTCKRVCPVENISIVDKKPKWGNECE
                     RCLACFHWCPKEAINVKKSFLTNRKKYHHPDITVKDIFLDK"
     gene            complement(21244..21705)
                     /locus_tag="KR257_001145"
     CDS             complement(21244..21705)
                     /locus_tag="KR257_001145"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888305.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MarR family transcriptional regulator"
                     /protein_id="HBH0029864.1"
                     /translation="MGGARDYLNGGKMKDFEKLYEATTKLVSTSLKVKDDLKKMFKQN
                     GYDITTDHYALLRFLWEQDGISQIDLCEKSCKDKSNTTRILDVMKNKGLIVRKVDVKD
                     RRKFQIFLTDLGRELEEPLNEIASIYATETFKSISDEELPLFTDILDRIGK"
     gene            complement(21681..22358)
                     /locus_tag="KR257_001146"
     CDS             complement(21681..22358)
                     /locus_tag="KR257_001146"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895507.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flavodoxin family protein"
                     /protein_id="HBH0029865.1"
                     /translation="MIITVINGSPRKNGATSKVLTYLYKDIERLIPDVKINYFDLSEV
                     NPSYCIGCLNCYKMGKCINQNDKVEYIHDIITKSDGVIFGSPTYGSSVTGLFKVFTDR
                     AHMMLERLLYRKPCIAVTTYENARGSKAISFIKSMVLDSGGYVCGSLSIKTGFNQNPI
                     TEKVESKIQKVSKKFIYCIEEKKNPPVLSQIYNFIAINAVLKPMAFKDIEQYKGIIDR
                     WEEQGII"
     gene            22591..22977
                     /locus_tag="KR257_001147"
     CDS             22591..22977
                     /locus_tag="KR257_001147"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895504.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="BlaI/MecI/CopY family transcriptional regulator"
                     /protein_id="HBH0029866.1"
                     /translation="MKKLPHISEAEYQVMKIIWKYAPISTTEVIEKLVETSTWSPKTI
                     QTMLLRLVKKGALTYEKNSRVFVYTPLVKEEEYVATESSSFLNRFYNGTLNSMVLNFL
                     ENDKLSEDDIEELREILNKRTTKGDK"
     gene            22980..24779
                     /locus_tag="KR257_001148"
     CDS             22980..24779
                     /locus_tag="KR257_001148"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426313.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="BlaR1 family beta-lactam sensor/signal
                     transducer"
                     /protein_id="HBH0029867.1"
                     /translation="MYAPFFIRFLLSTLTLSILIVVILLAKKVFKKHISAKYQYNIGF
                     ILLIMLIIPFVPLKYINLGNVFNYLYTFNQLGSSTNRTSMIKNSSNSVINNSNALNDF
                     SVSLNQVNFDSLNILLLISWIIGILIMIAITIHCNIKIKNMKKSIQILKDEEIVFIFE
                     KCKKDIGINKDFILCKSPIINTPITFGYFKPHIILPDKSISKLSLKDIKYILLHELQH
                     FKNKDILINYIMCFLQILYWFNPLVWYAFKEMRIDREIACDISVLKKLNKDSHIEYGQ
                     TLINFVDNISRPSNLTLTSDIGGSKKQIKKRLLKIMDFHNESNTLKFKSILIFTLIAL
                     IVFGNIPKLSIMADINEKYRPTNEQTVYEDLSQYFKGFDGSFVMYDLKSKQYHIYNKE
                     KSKTRISPNSTYKIYSALLGLENGIITRNNSHIPWDGKHHSNSSWNEDQDLFSAMENS
                     VNWYFQTLDKKTGLKNIQTYLRQIGYGNYDVSGGISNFWLESSLKISPIEQVELLESF
                     YTNKFKFEDKNIETVKDSLLISKKDGVSLFGKTGTANINGKDVNGWFIGYVEKNENTY
                     FFATNIQSKDYSNGSSASKITLSILNDKKIYNP"
     gene            complement(25134..27008)
                     /locus_tag="KR257_001149"
     CDS             complement(25134..27008)
                     /locus_tag="KR257_001149"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888302.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS glucose transporter subunit IIA"
                     /protein_id="HBH0029868.1"
                     /translation="MNKYNKIANELIKIIGEDNIISITHCATRLRVMVKDREIINDKK
                     VEKVDEVKGVFFTSGQYQIILGTGIVNKVYAEVEKMGLKTLSKKEQDELVKNNETGFK
                     KVMRTLADIFVPIIPVIAATGLFLGLKGCLFNDNVLGLFGMSSANIPLYIQTLVSVLT
                     ETAFAFLPAIIVWSAFKVFGGTPVIGLVIGLMLVSPILPNAYSVADPSNEIEAIMAFG
                     FIPIVGCQGSVLTAIVTAFIGANLEKWFRKHMPNVLDLIFTPFFVMLITMLVILLGVG
                     PIMHTIELKMVDIISLLIDLPLGIGGFIIGFTYPLAVITGLHHTYVMIETSLLANTGF
                     NALITLCAMYGFANIGTCLAFMKKSKNNQVKQTAVGAMLSQLFGISEPVLFGIQLRYN
                     LKPLIIMCASSGLGAAILSILHIQSNSYGLAVLPSYLMYIYDGYNLITYLLVSIFVVA
                     FCFIVTCLFGVPKEAINEDEDEELVFNENNENFVSPAKGKIVALENVPDETFSKKMLG
                     DGFAIDIIDGKIVSPISGKLETVVSSGHAFGIKGTNGEVLIHVGIDTVALNGDGFDVA
                     VKQGDMVKQGDVLVNVDLKRIHELGKSTLTMVLFPDGKKVNILDINKDVKIGQRICVE
                     "
     gene            complement(27013..28677)
                     /locus_tag="KR257_001150"
     CDS             complement(27013..28677)
                     /locus_tag="KR257_001150"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426300.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha-glucosidase"
                     /protein_id="HBH0029869.1"
                     /translation="MEKKWWQKEIVYQIYPRSFQDSNNDGIGDLQGIISRLDYLKNLG
                     ITSLWLCPIFKSPMDDNGYDISDYLDIASEFGSMEDLKELIKESKDRGIKIILDLVLN
                     HTSDEHPWFQEALKNPESPYHDYYIFKKGNDLPNNWRSVFGGSVWEKVENRDEYYFHS
                     FGKKQPDLNWENPILRSELYQMINTWSQMGVAGFRVDAITFIKKNLSFQSLESDGVDG
                     LVKCTKTVRNQPGIEKMLYELKENTFKKYDCMTVAEAAGISYDQLGDFIGEDGFFSMV
                     FDFKHADLDVASGSEWFKRISWTIPDLRKCILDSQMYVQEHGWAANFIENHDQPRATT
                     KYLLQYERNDDAVKMLGAMYFFLRGTPFIYQGQELGMTNFKRDTINDFNDLSSIDQYY
                     RSIDESYSEEEALEFVNLRSRDNARTPFPWADKENAGFSDTTPWLKVIENYKDINAQS
                     QINNSESILEFYKKMIKLRQDSEYSDCLIYGSIEPIDIESDDIIAYRRQLDLVVIDCY
                     YNFSDKPVEIRVEEKYDIVFQNLDDINLLNKTVRLKPFHAVLLKVR"
     gene            complement(28691..29512)
                     /locus_tag="KR257_001151"
     CDS             complement(28691..29512)
                     /locus_tag="KR257_001151"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426297.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Cof-type HAD-IIB family hydrolase"
                     /protein_id="HBH0029870.1"
                     /translation="MKLYKLLILDIDGTLRDEVYGIPESAKHAIRLCQKNHCSVVICT
                     GRSMGTIQDDVLSLGVDGYIAGGGNYIQYHGELLYNQSFNQRLIKEVVCLLKKREVAF
                     SIESQEKVFMNQKAKEIFETMNQLKGTNSCINKQHIQEKITYENNIEEYKSQDIHKIC
                     LWSNEKVFDEVKNILQDKMELAQRDISSQYYEIIQKDFHKGKAIKRLQERLGVTQKET
                     ICFGDGQNDVVMFQASDVTIAMKNSHQQLKDIATSICEDIFDNGIYKELKRRNII"
     gene            complement(29611..30375)
                     /locus_tag="KR257_001152"
     CDS             complement(29611..30375)
                     /locus_tag="KR257_001152"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434714.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MurR/RpiR family transcriptional regulator"
                     /protein_id="HBH0029871.1"
                     /translation="MKIEGLFNKYYNSFTANDKYICECILNHKEDCIKLSIDEFADKY
                     HISTSALSRFAQKLQLPGYSELRVIIRLNETEVEYKNQSKHQLMDCYNKVIDDIEKKD
                     CSIMFERMKKANRIIVFGEGYSQERVAKEMKRIFLPTGKIIYDVYGYDMIQALNHFIK
                     TDDMIFFISLNGDASTIIDFAKEMRMKGIYMVSITKMISNPLARLCDENLYIQSISIS
                     VDKQLDYDVTTPYFILIELLYIKYKMYLESEHIPRK"
     gene            complement(30372..31121)
                     /locus_tag="KR257_001153"
     CDS             complement(30372..31121)
                     /locus_tag="KR257_001153"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426291.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MurR/RpiR family transcriptional regulator"
                     /protein_id="HBH0029872.1"
                     /translation="MRLESLVNQNYDNLNENDKIIIKQILICQREYRNFSCEKIANEC
                     NVSRATLLRLCRKIGLDSFSDLKYLLKNNQLEFVNNDNNFHDVCENYRLLMNELQKIS
                     FQDICKIIYDAETIYIYGTGNEQKSLAQEIKRIFLSVGKCVIDLFDIGEIEFMRESFQ
                     KNDLFIIISLSGETKAGIEIAKFINNHIHTISLTRLDNNTIATLCEYNLYVETQKLDT
                     LQAISYEVVGAFYALLDLLHMNYIEYRRRKE"
     gene            complement(31625..32230)
                     /locus_tag="KR257_001154"
     CDS             complement(31625..32230)
                     /locus_tag="KR257_001154"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426278.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MBL fold metallo-hydrolase"
                     /protein_id="HBH0029873.1"
                     /translation="MKIKENVLMLDSTRGSNCFIVFDKEIILIDTGLPFMGKNIIKEL
                     KTLGIKLTDIKHILLTHHDVDHISNIKLLKEKTGAKVWAHVEDIPFIIGEKDRPGFKK
                     FIGKAISRRLIKDVEPYGENMQIGNIKIIHTPGHTPGHVCMIFEAVLFAGDLVKNKNG
                     NIVPYPNPWNWDYKKMVKSIRELDNLKYEWICMSHGTPCIK"
     gene            32409..33047
                     /locus_tag="KR257_001155"
     CDS             32409..33047
                     /locus_tag="KR257_001155"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003417472.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="HBH0029874.1"
                     /translation="MSELSKRDKEKIQRENEIIDKAEKLFCLNGFDNTTMNELAKEVE
                     YTKRTIYKYFSCKEDLFFAVVLRGYKRLWDNVKIESAKGKTGFEKIKLSYFAFHKFYS
                     VEPSLLCLMGMIGIVNSEKSDTDMLFKEKFFSFNKFMFDEIQGMFEIGKNDRSIRHDI
                     EIPTLMYSSIFTLTGFFNLLSVTGKSYLNNFNIDEEKFIETTLALLIDSIKA"
     gene            33179..33841
                     /locus_tag="KR257_001156"
     CDS             33179..33841
                     /locus_tag="KR257_001156"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009901935.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HBH0029875.1"
                     /translation="MAKILLLEDDDTITFGIKTSLEKKNHTVCCYNTIAEAKKNFDKT
                     IDLILLDLNLPDGIGYEFCQYVKSIEDTPVIFLTVRDDEKDIIRGLDMGADDYVVKPF
                     LLSVLQSRINAVLRRTHSNTNNTITCENISLNKVEVKAYLDNVEVPLTAGEYKLLLSL
                     MENKNRAMTRTKLLEMLWDVDGNFVNDNTLTVTIKRLREKLKNPPCIKTLRGIGYRME
                     DS"
     gene            33841..35022
                     /locus_tag="KR257_001157"
     CDS             33841..35022
                     /locus_tag="KR257_001157"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728749.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HAMP domain-containing histidine kinase"
                     /protein_id="HBH0029876.1"
                     /translation="MKTPRNINSTVVFIIFCLIVTFLLSVILTTITSFNEYNVLSKAL
                     GASYEYNPKSTESILKSLKNSSDKDFKTGNEILSKHGYSKSTFWSKNFFYFLVISFGI
                     ISTMATVIYIIKHRTNKQKLSRINNLTQYLEEVNLGKESVLLRCEDEFSHLEDEIYKT
                     VGELRCSKEFALKERQTLSDNLADIAHQLKTPITSMSLMAQLLSENCPDEEIDYINRL
                     TNQISRLERLVSSLLTLSKLDASTLIFESKLIDVHSLLTYAIEPIEGSLREKHQTFTI
                     EASPSVEFEIDINWTLEALLNILKNCSEHIEDGGYIVAYYSQNPLYVEIIIEDNGKGF
                     AQEELPYIFNRFYRGKNASKDSIGIGLALSKSIIERQNGTLHAENCHNGGARFIIKFY
                     T"
     gene            complement(35203..37863)
                     /locus_tag="KR257_001158"
     CDS             complement(35203..37863)
                     /locus_tag="KR257_001158"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728750.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBH0029877.1"
                     /translation="MNILQEYTLDFVRRNKRSSIAIMLAILLTTTMMSSLCGLLYTMW
                     TDFIRLSIEKEGNWHGELFDYTYGSDLPLIENFSSVDDVMVKGQWYVGKINDEKRDYI
                     IYRNATSEYWNSMPEKDTIIEGRRPNNANEIALSKQYFENNPSVKIGDKITLPIGYRI
                     LNGKPLEPIAPKSKGESFKKISEATLTIVGKVDVSTSSVIPAYTALGYLDKTSIKPND
                     SITVYLRFKNIRDTYKELPKLAKSLGWKTNEYGKYNLKYNSNYLLKMLVFSPEQKASM
                     SSISKFSTPIMYLTIAIFTVAVFVMVIYNAFSLSANARLTQLGILSSVGASPKQIKRS
                     VVFEGFLLTIIPLPIGLFLGWLLCNRLIVYVNSVNYHTDVPEVVFTYGIPAFLPAVLL
                     TIVTVWISALIPARKVSKISPIEAIRQGDSVKIKKSHKYSLGKIFGIEGELASNALRA
                     RKKSYRTATISLTLSFLLLTCFLHIIANQEGAKAVYGSDNYKDQRDIAVYLENSEPIE
                     SAFIEKLDNTEGVKSSLYYQKMSASTWLTEKDASKELAKNGGFKSIVSSKKYSPIERD
                     GKFRIISNIIGLDDKSFTEYCRQISVDPKLFYNTKNPTSIVYNKEEDINRSTRRNKVY
                     IDYLNLSIGDNIKLNEKVYDEDKGDYTYNMKVGAITSTLPKIVDTSSKYTLMQIVPMS
                     MVQEISKNYDEVSRLRSNRLIGVFKVNNREDIPRVREKLESIYNKDYGSGDYSIEDVL
                     ESEKQKASGIKTMNLIVGFITGLLAMIGLSNVLATVSGNIRSRRQEFAMLRSVGLSPE
                     GIKKMLILEGLFLGITPLLLSIPVQIGIVYAFLRINEIYFIEYLPFAPISTIIGFTIL
                     ILFIVIASYMTGYKQLKNENIVESIKNETI"
     gene            complement(37860..38543)
                     /locus_tag="KR257_001159"
     CDS             complement(37860..38543)
                     /locus_tag="KR257_001159"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426268.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBH0029878.1"
                     /translation="MEILKCENLTKIYGSNQTRVTALNNVNLSVQKGDFVSIVGASGS
                     GKSTLLHLLGGVDRPTSGKIYVEDTEISSLKEEALAVFRRRKVGLIYQFYNLIPTLDV
                     RKNILLPMLLDKRKVDEDRFSEIVSILGLSDRLNHLPSQLSGGQQQRVSIARSLIYRP
                     AILLADEPTGNLDRKNSEEIVDLLNLSNKRFNQTILLITHDEKIALEANRIVTMEDGV
                     IVSEKVVKK"
     gene            complement(38887..39840)
                     /gene="blaCDD"
                     /locus_tag="KR257_001160"
     CDS             complement(38887..39840)
                     /gene="blaCDD"
                     /locus_tag="KR257_001160"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434692.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CDD family class D beta-lactamase"
                     /protein_id="HBH0029879.1"
                     /translation="MKRKKNFIWIAILLVGVVMVMYYVGKKHNDINQKTDKNYIKSEL
                     NKSELNKSKIENNDKNKKEKINMVDYSDCFEGISGGAIFYNTKNKEYNIYNKELIETR
                     RSPCSTFKIVSTLIGLEKGVINSKESVMGYDGTEYPNKNWNKNLSLEEAFKESCVWYY
                     KKLIDKVDAKSVQNILDDLKYGNCDISEWEGDLKNGKGHLNGFWLESSLQISPKEQVQ
                     TMAKIFEGDTNFKKEHINILRDIMKIDINDKNINVYGKTGTGFDEKNKRVDAWFVGML
                     EREGDTYYFAIKSDDSNKEITGPKVKEIAINIIKKYYSVRE"
     gene            complement(40381..42495)
                     /locus_tag="KR257_001161"
     CDS             complement(40381..42495)
                     /locus_tag="KR257_001161"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434689.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding domain-containing protein"
                     /protein_id="HBH0029880.1"
                     /translation="MSENKQVVNCDIIASNSKHNMCEYDAELLTFFPDEIAHLIEINN
                     KLDNAFKKAENLVDKLDKDYMDAKMYMVKNRGEIDPHEMFQNEQGLKQIDNYGAFMVK
                     VRDKINKIKDSPYFARIDFRLKDMDDESKYYIGRFAFDYEDELIILDWRSPIASMFYD
                     YEIGKAGYDAPIGWVDGEITRKRQFKIKNGKLEYALESSINIQDDILQKELSHTSDEK
                     MKSIISTIQKEQNQIIRNDKADTLIIQGVAGSGKTSIALHRIAFLLYRFKDKISANNV
                     IILSPNKVFGDYISNVLPELGEEPLCELSFENIAEVQLDRVINFESEKDPLEINDAKW
                     SERVRFKSTLDFVKLIDDYIKQMPNKIFIPKDYTFGSFTAKSDWIQSRFEAYNRYPVK
                     KRLEKVAEDIHYKFESDNIMEEDLPKVKSILKSLNGMLTIKNTLTLYKDFFKQMNISN
                     MFVMAEKKTLEWSDVYPFIYIHAAYEGIQEDKIIRHIVIDEMQDYTPIQYAVINLLFK
                     CKKTILGDFGQLVNPNHTHTLDDMKQLYNDGELVMLNKSYRSTFEIINFAKKIQDISS
                     LEPIERHGEEPALLKCNNEQDEINKIKIEIEEFKKSDNATLGIILKTDNDAKAVYDAL
                     REEYSVHLISSESSSFTKGVSITSIKMSKGLEFDEVIVPSVNNKTYYSDYDRSLLYIA
                     CTRAMHKLKLTYTCELTQLIDM"
     gene            complement(42579..43415)
                     /locus_tag="KR257_001162"
     CDS             complement(42579..43415)
                     /locus_tag="KR257_001162"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728753.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HBH0029881.1"
                     /translation="MSYKVINVITAIDYIEEHLSEKLDLDIVANAVHYSKYHLHRTFT
                     TSVGLTMHDYIKRRKLTEAAKLLVFSKKPIIEIALIAGYESQQAFTSIFKAMYKKSPN
                     KYRKEQEFYPLQLRFVLKKDNLFSKNVLELEKEIKLASMSDIPLWMNLVRLVIDGFPN
                     LQEEEYIYQLEQYILEERALILKLNNVAIANMVFNRETRSIDFFGIHPQYRNSDIAQV
                     FLKKVIEDFLIDTDISITTFREGDKADTGHRDMIKKLGFAEAELLVEFGYPTQKFILP
                     LS"
     gene            complement(43999..44361)
                     /locus_tag="KR257_001163"
     CDS             complement(43999..44361)
                     /locus_tag="KR257_001163"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434678.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="VOC family protein"
                     /protein_id="HBH0029882.1"
                     /translation="MKIYDILTRFYIQDIEKAIPFYENLLKEKCSLRFSYKEVGLELA
                     QIGNVLLLSGSDDALKPFIETKSTFMVDSVDEWRSYLLDNGAVVVRDKKKVPTGYNMT
                     LRHPDGTIIEYVQHTKQD"
     gene            complement(44595..45059)
                     /locus_tag="KR257_001164"
     CDS             complement(44595..45059)
                     /locus_tag="KR257_001164"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860814.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GyrI-like domain-containing protein"
                     /protein_id="HBH0029883.1"
                     /translation="MTRISNITIAEQSEYCFLAIRKTIDFMVEFSEFSKQSFEKISKY
                     LEERGILSSGAPIVCFHNMDLVKLDVEVGFPVATYIDGKNEILQKIVPAQKIITAIDL
                     GLYELQDPTLEDLFSWANSNGYKLHGDIYYQYLNDINRPASEYLTKMMLPII"
     gene            complement(45488..46909)
                     /gene="nhaC"
                     /locus_tag="KR257_001165"
     CDS             complement(45488..46909)
                     /gene="nhaC"
                     /locus_tag="KR257_001165"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009901909.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Na+/H+ antiporter NhaC"
                     /protein_id="HBH0029884.1"
                     /translation="MKERECRKASLFDAMIPITCLILFLSLGVLVYGSSPHVPLIGAA
                     AVAGLVAVYRLGFKWKELELSMFNSIKMAMQAILIIIIIGVLIGTWIVSGVVPCMIYW
                     GLKILSPNIFLVASTLVCAIVSLATGSSWSTMGTVGVALLGIGQSLGMPIGLIVGSII
                     SGAYFGDKLSPLSETTNLAPAMAGTDLFTHIKYMLYSTIPSLLICLVIYGVIGMKYSG
                     QALDIKQIELIRSTLDSTFNTLSPVLLLAPAIVIGLVVFKVPAIPGLIVGAVLGVLFA
                     VVFQGESMNTILDAAQNGYVSSTQIQEVDALLSKGGIMNMMSTVSLTICALSLGGILE
                     KTGMLEVVASSLLRLAKGVFGTVLCTMVTCTITNIIAGEQYLSIVIPGRMYNKEYKKR
                     GIHPKMLSRALEDSGTLTSPLVPWNTCGAYITATLGVSALTYGPYALLNIINPIVSLV
                     LIACKFKIARIEDEPETCLNFDV"
     gene            complement(46939..48003)
                     /locus_tag="KR257_001166"
     CDS             complement(46939..48003)
                     /locus_tag="KR257_001166"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728754.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alanine/ornithine racemase family PLP-dependent
                     enzyme"
                     /protein_id="HBH0029885.1"
                     /translation="MYPRLEIDIEKLKHNAKLISQMCHERNIKISFVTKSFCAQKEIV
                     EEICSEGIDHIADSRIQNLKNLQDINLPKILIRIPMLSELEEVINYCDISFNSELGTI
                     KKLNELCESKNIIHKIVLMFDLGDLREGYFYEEDFFNNVREIVRLKNIEIIGIATNLT
                     CYGAIIPSRENIGRLVSIAKRMEEKFGINLEIVSGGNSSSIHLLINNNMPEGITNLRI
                     GESILLGRETAYGENINGTYQDAFKLICQVVECKEKPSVPIGEIGVDAFRNKPVYEDK
                     GILKRAIIAIGKQDINIDSLIPIDTDIKILGASSDHMILDVSNTKYDYKLGDNLEFLL
                     TYGGIMSSSTSKYVSKKIIV"
     gene            complement(47988..49397)
                     /locus_tag="KR257_001167"
     CDS             complement(47988..49397)
                     /locus_tag="KR257_001167"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003417439.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glutamate mutase L"
                     /protein_id="HBH0029886.1"
                     /translation="MENSKVSLKIDVLVAEIGSTTTVVNAFHDINTNNPIFLGQGQAP
                     TTVFEGGDVRNGLSGAIKDLANKLSVDDIEYNDMFATSSAAGGLKMTVHGLVYDMTVK
                     AAKEAALGAGAVIRQITSGRIKRTDLNKIKEINPNIILIAGGVDYGERDTAIYNAEMI
                     ASMNLGIPVIYAGNVENQEEIRLIFEDTNYKLYITENVYPKIDLLNIEPTRRIIQSVF
                     EEHITTAPGMKYIKEMVNENITPTPGAVMEASKLLYKNIGDLLTLDVGGATTDVHSVT
                     DGSDYINKILVNPEPTAKRSVEGDLGVYVNMKNIVEVIGKENLQSELSIDIDAVIENY
                     PPIPKSKEEILFVERLTKEAVVKAMLRHSGKIRNIYGTTGKVKIAEGKDLTEVRYIVG
                     TGGALTRLPSRIEILDNMLKYNKNNELLFPKEKTKILIDNDYIMASMGVLSKKYEEAS
                     LKLLLKSLNFEEERLCILG"
     gene            complement(49397..51601)
                     /locus_tag="KR257_001168"
     CDS             complement(49397..51601)
                     /locus_tag="KR257_001168"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892628.1"
                     /note="Presence of a B(12) (cobalamin)-binding domain
                     implies dependence on cobalamin itself, in one of its
                     several forms, or in some unusual lineages, dependence on
                     a cobalamin-like analog; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cobalamin-dependent protein"
                     /protein_id="HBH0029887.1"
                     /translation="MLKENKKLDIDYILKDLDKYKPKRRGWVWREHLENLEMGPFKYK
                     DCTKPLKKSVGLPSSKYFNNIDPQPSPVITTEIASGRFEDDIRRMRMAAHHGADHLMV
                     IRTAGQSHFDGLIEGTPQGIGGVPITRKQVRAQRKALDFIEEEVGRPINYHSYVSGVA
                     GPEVAVMFAEEGVNGAHQDPQYNVLYRNINMVRSFVDACEAKKIMAFANIAQIDGAHN
                     ANATAREAWKVMPELMVQHALNSIFSEKIGIDKSNICLSTVPPTAPPAPCLKIDLPYA
                     VALRELFSDYKMRAQMNTKYMESSTREATVTHVLNLLTSVLTRADIQSTITPDEGRNV
                     PWHIYNIEACDTAKQALVGMDGLMDMIELKDVGELRDKARELKERAVLYMEEISEVGG
                     YFESVEQGFFVDSGNYPERNGDGISRKIKGGVGEGTVYEREEDYLAPVTAHFGYNNVA
                     QYDENAIDNPSMLIDGCTFENPDKIIYIDELDDFDNVENRLKESYEYRNGTKIKPEME
                     WCADGIIMITMMLPTDKRTAEFAALEFVKKMNLQEIEVISREVMHESEGTRIEVKGRV
                     PFDIDLNNLVIPEEPKVLTDEEIRADIEEKPMKIVSATVGEDEHSVGLREIIDIKHGG
                     IEKYGIECHYLGTSVPVEKLVDAAIELNADAILASTIISHDDIHYKNMKKLHDYCVEK
                     GIRDKVMIACGGTQVTPEIAVEQGIDAGFGRNSKGIHVATFLVEKRREMSNK"
     gene            complement(51595..51969)
                     /locus_tag="KR257_001169"
     CDS             complement(51595..51969)
                     /locus_tag="KR257_001169"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003417434.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ornithine aminomutase subunit alpha"
                     /protein_id="HBH0029888.1"
                     /translation="MKKREDDFEVRRKHLQELSDDELKERFWSLATQIVEPMIELGKK
                     NTTPSIERSVLLRMGFSSLEVKPILEGVMERGLIGKGAGHVVYKLAKSKNITVREAGL
                     LLVKGEYWDEVTCLFREGVESC"
     gene            complement(52047..53477)
                     /locus_tag="KR257_001170"
     CDS             complement(52047..53477)
                     /locus_tag="KR257_001170"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888273.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PLP-dependent lyase/thiolase"
                     /protein_id="HBH0029889.1"
                     /translation="MNNSTSMKDMSYQAVMGRNNEIMKNAIGLDYSSFEQEGIGFDYE
                     KMMSETGYTLQDIEAIQSQYAVGNTPLIELKNLTKLARKCAKEGKGARIFVKDEAMNA
                     SGSFKARRAATAVYHAKQMGYKGVIAATSGNYGAAVASQAAMQGLKCIIVQECYDSNG
                     VGQPEIIEKARKCEAYGAEVVQLTVGPELFYTFLVLLEETGYFNASLYSPFGIAGVET
                     LGYELAIQFREKYKKDPDIVVCTNAGGGNLTGTARGLIKAGSINTKVVGASVDLKGLH
                     MASDNQFNKKSFTTGHTGFGIPYCTWPDRSDVPRSAARPLRYMDRYVLVKQGEVFYTT
                     ELLAQLEGIERGPAGNTSLAAAFSLAQELDEDKAIVVQETEYTGAGKHICPQLTFARE
                     NGIDIKFGNPREEIAGVNLILPERPELLKCVDIDMNKIRKSFIKNCISNNHIDNIDKL
                     SNRDIEFLMEEVKSSRDFVVDVLNNL"
     gene            complement(53470..53778)
                     /locus_tag="KR257_001171"
     CDS             complement(53470..53778)
                     /locus_tag="KR257_001171"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426242.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="2-amino-4-ketopentanoate thiolase"
                     /protein_id="HBH0029890.1"
                     /translation="MDAKINDWVIIHNIVLTPEERAPQVPEDTKKVSLEMWVKGFIQS
                     DASIGDLVEVKTITGRLVKGNLLKINPYYTHDYGKCIPELLQIGIQAKEILFGGVYNE
                     "
     gene            complement(53899..54966)
                     /locus_tag="KR257_001172"
     CDS             complement(53899..54966)
                     /locus_tag="KR257_001172"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434659.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NADP-binding protein"
                     /protein_id="HBH0029891.1"
                     /translation="MRKVRVGIWGFGAMGIGMANMILKKEGIEIVSVCSRSTSGKSMY
                     DVLGIERGERPEVIINKNYEEVFREKSVDVVLLATDSFTKKAFDKINFLLNRKINVIS
                     TAEQMAYPQADDADLAKKMDEVAKENGVSILGTGINPGFVLDLLVLALSGTCEEVTSI
                     KAKRVNDLSPFGKSVMVEQGVGVTREEFIKGVEDKTIAGHVGFVESINMIADGLGWKL
                     DKIEQTKEPIMTTVDRKSKYGEALAGNVAGCRQCGYGYVNGEVLIEMEHPQQIIPEAE
                     GIKTGDYVSIKGIPNIDLQINPEIPGGVGTYAMIVNSIPLIINARPGLKTMLDIPVPR
                     AIMGDIRNQIEVELEEESKAN"
     gene            complement(55222..56595)
                     /locus_tag="KR257_001173"
     CDS             complement(55222..56595)
                     /locus_tag="KR257_001173"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426237.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sigma 54-interacting transcriptional regulator"
                     /protein_id="HBH0029892.1"
                     /translation="MNEILENIDEGVHFVNKDGKTIIYNNSVQKMEKMNRHDILTNSF
                     FDIVNKMKINRSTLLEVLEKREVIKDNIQKYLDKNGKEITAINTTIPIDIKGEFVGAL
                     EISKNMTTIENLLNRNYKKNLVNKVSIRQKKGYEFDDILGESNLIKEAIAKSKKACKS
                     DASVFIYGETGTGKELFSQSIHYGSNRRNYPFIAQNCAALPESLFEGILFGTSKGGFT
                     GAIDRPGLFEQANKGTLLLDEINSMPIMLQAKLLRVLQEGYVRRVGGTKDIPIDVRII
                     ATTNESPKVILNEHKMRKDLYYRLNIIHIKIPPLRDRKEDIPLLCKKFISKYNKKLNK
                     KVVGISDEAIKILKNYDWQGNIRELENIIYCTMSMMEDEVQIETSMINLNDYYTLKEN
                     KESNNYSLNDLEDKTLSKIISEIEEKYIYESLEKASYNITKAASILGMNRQNLQYKIK
                     KYNIKIL"
BASE COUNT        19242 a         9664 c         6750 g        21142 t
ORIGIN      
        1 tttaaaattt aatctattat aaaattaccc taattgccaa actttttaat ataaattttc
       61 caacatccta caaatataat caatagatat agaatcctaa cttacaccaa tatatattta
      121 tttaaaatag tcctaaaata cctgtaatag ctcccactac tatcagtata aacattattt
      181 ttattggaga aagacctttt tttaaagcaa agagtactaa taaagtaagt accaaaggaa
      241 ttaacccagg aaatatctta tcgagtaaat ccgtttgaag actaaattta aaatcaccac
      301 tagtataact tattggtgta gataaattaa taaacctacc tacaagtccc cccatgacta
      361 aggtacctag tatagaagcc ccttctataa ccttatttac tattccacct tgaagtatac
      421 tttcaacggc ttttttccca tacttatatc catttgtcca cattccaaaa gaaattgaag
      481 tcattattat atattgagct attacaaata atataggtcc tgcaattgat gctcctccct
      541 cagttaaacc aatacaaaca gccaacacta taggagttat aactccttga gttaaagtat
      601 cgccaattcc cgctagtgga cccatcaagc ctgttttgat agcattcata ccatctccac
      661 ttatttcatc tgctccatta gctttttctt cttccatagc tattgttatt ccatgtataa
      721 cacatccaca tataggttct gtgttaaaaa atgctagatg agtctccact tcttgtttta
      781 actcttcctt atctggatat aattttttaa gtactggcaa cattgaatgt gaaaaagctg
      841 ttgattgcaa tctttcataa ttgtaattag attgtgcaaa gaaaaaccat cttaaccatg
      901 attttattac atctttcttg cttaacgttt tcttagatac ttcatttttt atatctgaca
      961 taatattttc cccctcacat gtatttaaga tgtagcacta tcttttccgt acttaattga
     1021 agtaattgta agagcaagta ttactccaat aacagatatt actattatat ctactttaaa
     1081 ataaacagcc attagtattc ctaatatgaa aaagggcata gtaaacttgt ttccaatcaa
     1141 ttttaaattc atagcaatcc caagtgctgg caacatagcc ccaattacat taaatacatg
     1201 taacacatta tcattcatta cttccaacat accatctatc gcatttggac caaaataaac
     1261 aactaataat gctggtataa aactcattgc aaataacagt atctgtggtg gtactatatt
     1321 tataaatgct actctatcaa cattcccttt ttgaacctct ctatcagccc aatgtgcaaa
     1381 aaaagaattt actgtcatct ttccaatcca aagtacagtt gcaacagttc ccaatggtac
     1441 agctattgcc attgcagtac ttacatctag cttagatgct atagctaaag cagtacctac
     1501 atatcctgca aaagctgggt cccccatctg agctccccct gctgatataa aacctagata
     1561 tatcatattt atacctgctc ctataattgc tccttgaaca gggtctccta atataattcc
     1621 cgttacaaat ccagccaata gaggtctatt ccatgtaaaa aatccaacat aagtcaacca
     1681 cggactccaa gaaagataat aaaaaattgc tattaatact gcttgaatta gtgaaatgtg
     1741 catattcttc ctccctattt tcttttaaag atttacaaga tagtcttctt tacaataatg
     1801 ttcctacatc aattttcttt gcatctggta ctatttgtat aaagcattta acatcttttg
     1861 atattagctc tctaaatatt tctttttctt catctgacac agatatattt ttataaaaac
     1921 tttttctacc aagccctgct cccatacctc caacattcaa ttcctttaaa tctaccccgc
     1981 tatttactaa acctaagaca gttttagggt atttgaccaa tactattaaa ttttcatctc
     2041 cattatatga ttttaagact tcagcacctg attctacatc atgtacttca accttaacag
     2101 ttgatggagc tgccatttgt aaaacttgaa ctataaatgg gtcctttact actaaatcat
     2161 ccacgattac tatccttttt gctgatgtaa tcttacacca agcagtaata acttgcccat
     2221 gtattaatct atcatcaatt cttgttaatg ctatattact cataattatt cctccagatt
     2281 tttaatttat tttacaactt taaaacagtt ttaacatctt tgattcctga tatcccaact
     2341 tcctcacata aattcttcaa gtcttttaac ttcatagtat ctctgtttaa aaataactct
     2401 aaaagcatag gtaaatttac acctgtcaaa cattctaact cacatacctt agcaaattta
     2461 tttattataa tagcagatgt attaaatgga gttccgccat aaaaatcaag caatactaaa
     2521 accccttcat ccttatattt ctcaattcca tcttctaact ttctactaaa ctcatctatg
     2581 ctgtcaccat ggtttaatcc taaagtttct acattttcct gtttgcctac tattaattca
     2641 gcactttcta acattgcttt agccatattt ccatgtgtgg ctataattat tcctgccata
     2701 tgaatcatac ctttcttaac cttttttata tggattatta tttagtactc taatctaatt
     2761 atctatatta atcattatct taccaaagaa aatatccctt ttgtatactt tttcaaaata
     2821 agctggtact tcttctaaat ttattctatg tgttactaat ttttcaacat tcatgtcacc
     2881 cttttgcata tgatacaatc cagcactcca ttcttttcct gggaatggaa aggagtttcc
     2941 aaaccaagtt ccctttacag ttaattcact tcttactatc ttttcaaatt gctctctagt
     3001 caaagctaca tccccatatg gtacacctgc atacaatact gtacctccct ttttagctag
     3061 caacagtact tgaccacatg tcagtggagt accagccgat tcaataacaa tatctgcacc
     3121 atctccatca gttaaccttt ttatttcttc tacaatattc ttttcttttg catttataca
     3181 aatatctgcc cctaactctt ttgccaagtc taacttctca tcaaatacat ccacagctat
     3241 tatttttgta gaaccaaata tttttgccca ttgtattgaa aataatccta ttggacctgt
     3301 accaagtact acaacagtat ctccaacttt agcttctgac ctaaaaagac catgtcctgc
     3361 tatacatact ggttctagcg cagcggcagt ctcataactt atctcatctg gtatttttat
     3421 taaatttctc tctttcacct ttgtatactc tgcaaaacaa cctccaagtt ctttatttcc
     3481 tattattgct acattattac atcttgaata caagcctttt ttacattcat cacattcaaa
     3541 acatggcata gctggacaaa cagcaactct atctcctatt ttaaaactcc ttacttcttt
     3601 accaacctgt gccacttctc cagaaaattc atgccctaaa atttctccaa ccatatgtgg
     3661 acctgtcttt gaatattttg atatatcaga accacatatt ccagctactt ttactttaat
     3721 tattacatca tctttttcta atatttttgg tacatccaca tcctccactc ttgtgtctct
     3781 tataccatag aatctaactg acttcactat taaccacccc tactttttat ttgagaatat
     3841 atccctattg tttatatgtt aaatatctaa agcaactttc atgccaatat atgtaagcat
     3901 tgtattcatg cattttataa aattatcatt aaatgtgtgt caaagtgtgt caaaagtttc
     3961 ttatattaaa acttatgtgt gtcaatataa acgacactaa cattttatat tagttctctt
     4021 attataagtt ttataaaatg tacttttttt gttattttta taaaattgtt cggaaatttc
     4081 ccttctattt gtgatataat attaaatata aggtatcaat ataaattttc atgcgaatat
     4141 cagaactttt ttgacactaa tgccttattc aatataataa tttaactttt tggaggttgt
     4201 ttatgaaaaa agtgtatcaa ggaaagacta aagatgtttt tgaattagat aatggaaatt
     4261 acttacttaa atttaaagac gatgtaactg gtaaagatgg agtatttgac ccaggcgaaa
     4321 atagtgtagg tctaagtata gatggaattg gtagagctaa tttagagaca tctgttaagt
     4381 tctttgaaat tctaaacaat gctggaatta aaactcatta tgtaagtgct aatttagaag
     4441 aagcaactat ggaagttcta ccagcaaaag tttttggtaa tggattagaa gttatttgtc
     4501 gttatagagc tgttggtagt ttcttacgtc gttatggttc atgtgttgaa gaaggtgcta
     4561 aactagattg ttacgtagaa gcaactttaa aagatgatga ccgttgtgac cctcttataa
     4621 catctgaagg tttagaagct ttaaacatta tgactcaagc tcaatttgat tcaatgaaaa
     4681 gcatgactca aaaaatttct aacatagttc gcgatactat agctgaaaaa ggtcttgagc
     4741 tttatgatat taaatttgaa tttggattct acaatgatga agtaatctta atagatgaaa
     4801 tagcatctgg aaatatgcgt gtttataaag atggtgtaat agttgaccct atggatttaa
     4861 ctgctctttt attagataaa tagtatatac atataattta caaatataat aaacttataa
     4921 ataagataag ctatgaagta aagacttttt aaatgttgat tatttttaaa cattttctcg
     4981 cctttaattt catagcttat ttaaattaat atactctaat tagtagataa tagctttaac
     5041 cctacaattc ccaccacaat aaaacctata catgcaattc ttgatatact aataggctca
     5101 tttaaaatag ccatgcctac aatagctgta ccgacggtac caattccagt ccatattgca
     5161 tatgaagttc caagtggaag atgttttagt gctaatgaca aaaaataaaa acttacaatc
     5221 attccaacaa cagtaagtat acttggagtt aatttagaaa atccatgtga attttttagt
     5281 tgaaaagccc aaaacacttc aaacaaacct gcaacaaaca aaaataacca tttcataaat
     5341 tcatccctct tttcaaatat gtctcttatt tttccaataa aataacctga gaaatattat
     5401 aaaatatctc ccaggttttt gtccttccgt gttcacaaca aaaactatgt tgtgggtttt
     5461 atctcggacc agaccaatca ttaataattg cggaacccta taaaactcta ttaattattc
     5521 tattttatct ataataatac tatcaacata tataaaaaaa gtcaatatat gggttccata
     5581 tataataaaa ataactttta tatacctttt aatattctta ttcacttctc tccataccca
     5641 tttgggtcaa tctaagaata tctaattttt atttaatatg ttataataac ataaaaatat
     5701 tgaaaggagt aatttctatg aatttctata aaattgcagt atgtcagatg attactacag
     5761 aaaataaaat tgaaaatatc aatcatgctg tagatatggt aacagaagct gccatcaatg
     5821 gatctaaaat tgtagttttg ccagaaatgt ttaactgtcc atatgaaaat aaatattttc
     5881 ctaaatttgc tgaagaatat ccaggtgaaa caacaacaat attgagtaaa ttagctgaga
     5941 aacatggaat ttatctagtt tctggtagta ttcctgagtt agaagatgga aaaatctata
     6001 atacttgcta tgtatttgat aaaaatggag ctctaattgg aaaacatcgt aaaatgcact
     6061 tatttgacat tgaagttaca ggaaaagtta gttttaaaga atcagatact cttacagctg
     6121 gaaatgatgt tactgtaata gataccgaat atggaaaagt tggtatagct atttgttatg
     6181 atattcgttt ccctgagtta tcacgtttaa tggctcttaa aggtgctgaa atcgttatct
     6241 tgcctgctgc atttaatatg actactggtc ccgcccattg ggagttatct ataagaatgc
     6301 gtgctttaga taatcagata ttctatgttg gtgctgcacc tgctagaaat atgaatgctt
     6361 cctacatagc ttttggaaat tcaagaattt cagacccttg gggaagaata attgctcaag
     6421 ctgatgaaaa agaatgtatt atttatgctg acattgatag agatttaatt cctgacataa
     6481 gacaacagtt accacttctt aagcacagaa gaactgattt atatgaactt aatactttga
     6541 aataaaacag aacataaccc cataaatcat aaattaagtg ttaaaaaaat ttatggggtt
     6601 ctcattaatt tgatttaaaa ttaatttcat aaaaataata ctaatattaa tttaattaaa
     6661 taatactaat aattactaat gattatgcta attatcagca tttactaatt taatcactat
     6721 tagttatttc ttttattaaa tatctttact ttttttactt attatgtctt ctagctttac
     6781 atttggatta tagtatttct ttctattttt agtcacatct ttctattgaa ttacttgctt
     6841 aaaacaccaa tgcacacatt ccagacaatg ttcacaatta tgtaaaaatc ttgctctacc
     6901 ttcttcaatg ttgatattat ctctcctagt tgatattatc tttcctaaaa tttcttttaa
     6961 ttaaaaaaca acattcgttg atatatcgag tatattttaa gcaactgaaa aaaacaataa
     7021 taattgatat atcaactaat taatgtagat taattcattt ttataattta tatacttttt
     7081 aattaatcta cctttttaat taaaattctt cctttctatt tatccatttt aaacttaaat
     7141 tataagattt catcagctgt gtttttgcat tccaataagt attaaatatc aaatatatat
     7201 tctattaaaa tttctaataa tttcatcctt gatttattta atatataaaa atatactaac
     7261 tttaatgatt aagttttgaa atataactaa gaatttgaga ttttattgag atttttatac
     7321 taaagtatac atactataca agcttaattt agaagggagc attcttatga acaataaaat
     7381 actcgtcgta gatgatgagg aaggtataat aacactctta aaagattact ttgaaatgaa
     7441 tggttatgag gtttacactg ctcaaagtgg aaaaggcgca ttaaaaaaaa tatccaaaaa
     7501 tccagatatt attctacttg atataaacat gcctgaaata gatggaattg aagtttgtaa
     7561 tagaattaga gattatgtat catgccctat tctatttctt acagctagaa ttgaaaatac
     7621 tgacaagata aatggttttc gtgctggtgc tgatgattat attgtaaaac cttttgattt
     7681 agacgaactt ggagctagag tatctgctca tttaagacgt gaaaaaagga agtcaaatca
     7741 aactaaaatt aaattttata atgatttaac gatagattac gaaaaaaggt taatttgtat
     7801 agataataat cagatttcac tttcaaaaaa ggaatttgat atagtagaac ttctctctat
     7861 gaatcctgga caagtatttg ataaagaaaa aatctatgat agagtctggg gatacaatag
     7921 caatggaaat agtgatgtta taatggaaca cattagaaag atacgaatca aactatcaaa
     7981 acatactctg gaaaattata tagaaacagt ctggggagtt ggttataaat ggataaaata
     8041 aataatatgt cattaaaaaa agctttcttt gttcttactt tatcttcact aattatagca
     8101 tcaacactta ctactttctc atacattttg cttaataatc tatataattc tatacaagat
     8161 aagtatttaa aaacacctat aaatacgggt tttataacca tagttcaaaa caatgtgaac
     8221 caatttagtg attatgataa aacgttactt aatataatca acatacttca gcttgtactt
     8281 ccacttatat tttttatagg acttttatta ttagctgata taatttttta caaggtaaaa
     8341 ttaaaaacac ccatagaaat actcaataaa ggtgcaatgg aaatatccaa caacaattta
     8401 gacttttgct tagagtataa taataatgat gaattaggta atctatgtaa tgcttttgaa
     8461 aaaatgaggt ctgaactaaa taaaaacaac ataaagatgt ggactatgat taatgataga
     8521 aaacaactta atgctgcttt ttctcatgat ttaagaaatc ccctaacagt tctaaaaggt
     8581 tactcaaact atttaacaaa atacatacca acaggtaagc ttagtgatga gaagatttta
     8641 tcaaccacac aacttatgtc tgagcatatt aacagaattg aatactatgt agaaaatatg
     8701 agtaatgctc aacgattaga agatttagtt gtttcaaaat ctatgtcgaa tataaacaag
     8761 tttatagaaa acttagatga aaatatatct atcattgcta aacaagaagg aaaatctttt
     8821 acacttaaaa gtcaaataaa taatataaat ctattttttg atgaaaatat cattcttaga
     8881 gtcgtcgaaa atataatatc gaatgctttt agatatgcta gaaataatgt atccatactt
     8941 atatatcttg aacaagaact ccttaccttt gtaattgaag atgatggtat aggatttagt
     9001 aaggaatctc taaaattagc tttaagacct ttctatagag ataagacttt aaatgacagc
     9061 aatgcacact ttggtatggg tctttatatc tcaaaaatat tatgtgaaaa acatggtggc
     9121 tctatttcta ttgaaaataa ttctactaac agtgctaaaa ttactgctaa attctcaaca
     9181 agaaattaaa atgattttgt aagctttcac tgctattata taaaatttgt tagtttagaa
     9241 tttataaaat gtatttcaat ttataaccaa tatatatact attttgtaga aattgtaaga
     9301 gttgcttcaa ttataatatt ttggcaaaag gcatttgaaa caataataga aatatatatt
     9361 taaatatgta gaatagtatg aaattagaat tttggaggtg attatattaa aagttttgct
     9421 aataatatta cattctctcg tattgtgttt gcattgctaa tgcttagttt tacattctgt
     9481 tcactgcctt tctggatatg ttatttttgg tgtggaatta gtgatatatt tgatggtctt
     9541 attgcccgaa agttgagaca acaaagtgga ataggtgcaa agttagatag tattgctgat
     9601 ttcatttttt cggttacaat tttggttact gtcggaaaaa atattgctct tcccatgtat
     9661 ctatggtggt gtattgttgc aatagcattg ttacggttga ttagttacag tattggtttt
     9721 tttaagtatc gcacattttc atcgcttcat actttgatga ataaaatcac tggaatttct
     9781 atctttgcgt ttccattact ctatatttgc tttggtcttg atgttgcagg aattatgata
     9841 tgtatcgtgg cttttctttc ttcttttgaa gaaatagcaa ttatgataaa atcaaaagaa
     9901 ttaaatcgtg atataaaaag tatatttatg tgaaaactta gaatttgtga caaaaataat
     9961 ttatataata atgaggaagt aaaacataaa aaattatcca caagtttatg tgtaaaatag
    10021 ttttaaagca atagagttgt attgtaaagc ctttagtgca taaattacat tttaaattaa
    10081 aaatgatact gaaactgctt atcagcactg cgaattatcc gcaaatagtg aagacttttt
    10141 agatttaagc taaaagttgg gaaaaaattg agttttaaaa cttacactct tcttatatag
    10201 aaaaggagag tgttttttat gattataaaa gcaaaacaat tatcaaaaat atatggttct
    10261 aataacaata aagttatcgc acttaataat gtaaatttag aaataaactc aggtgaattt
    10321 gtttctgtaa ttggaccttc tggaagtgga aaaagcacac ttttacatat tttaagtgga
    10381 ttagataatc ctacctctgg acaagtgtta cttgatgata aagatatata taaacacact
    10441 gaaaaagaac tatctgcact tagaagaaaa tcctttggat tcgtctttca acaatttaat
    10501 cttttacctg ttctgacagc atctgaaaat atttcaatgc ctgtacttct agataaaaaa
    10561 caacctgata aagaatattt aaatgaaatc tcatcattac ttggaattgc agatagactc
    10621 aatcatcttc cccatgaact ttcaggtggt caacaacaaa gagttgcaat tgctagagca
    10681 cttattgcaa aaccagatat aatatttgct gatgagccta caggaaactt ggacagtaaa
    10741 agtggcagtg aagttatgaa tcttcttata aaaacttcaa aacagtttgg aaagacttta
    10801 gtggtaatta ctcatgatga tagaattgca aaacttgctg atagaaaaat ttcaattatt
    10861 gatggtgttc ttatggaggt gaaatagaaa tgaagaatta cctttcactt tcaataaaag
    10921 aattaaaaag ccagaaactt atgactacat tcatcattat agcaatagta ctatcaacta
    10981 ttatgacaac tgtggttgga cagtcaattg gtatcctaca aaatttaaga attgaacaag
    11041 cccgttcttt taacggtgat agacatgtat cctttcacca acttactaaa aatcaagttg
    11101 atgacataaa gaaagatgat agagtttatc aagctggtac ttcaataact cttggcagta
    11161 gtaaaataaa ggattctggt atctctgtac ttgtaaaaga gtatgataaa acaggacttt
    11221 ccaactaccc caaattaatg aaattaaaat ctggaaattt gcctaaagat aaaaacgaaa
    11281 tagccttaga tgaaaacaca ctaaagctta tgggtataaa accaagacta ggagtgacta
    11341 tacctatgaa tttagatatt tcacttttaa atgatacaat accaccatat aattacacag
    11401 ctaactttaa attgagtggt attttagagg atgattatac aggatatgta agtggtatag
    11461 taaacggtat tgtaggcaaa ggtgcatcag aaaatctatt acctaagaga tatattttat
    11521 cctctttgga ttttaaaata aaacagcaag agaagtttca agaaatagta aatcaattag
    11581 ctaaaaaaat aaatctttct cacaattcaa ttcaatataa ttggatttac ttaaatgctc
    11641 ttaaaataca gtttgaaaaa gatgaaaata gttctaatag tgatggtata tctatgatta
    11701 tattggtatc tttatttgtt gccttattgg ttttactggc ttctggactt gtaatctaca
    11761 atattttaaa aatctctgtt acaaagaaaa ttaaggagta tggatgttta agagcaatag
    11821 gagctgaacc aaaccagata tataagatag ttattttaca aatcttaatt ttatgtacta
    11881 ttgccatacc tattggagct gtaattggaa ttatatcttc taaaggcata actggaatgg
    11941 tcactaatat cttaaatcca gatatacttc tagcaaatga taataaagaa attactgagc
    12001 ttatacataa aaacacaaca gcatatatat tcccattagt attaagcact agtatatctt
    12061 tgattttttc acttatttca gcattaccat cagcaatata tgcttcacat gtctctccca
    12121 aaattgctat ggctggcagt actaccaaaa tcaaaagaaa aattaaacga gaaaaaacaa
    12181 taaaaaactt tgaaagacat ctagcctggc taaacttaaa aagaaataaa ggaagaacta
    12241 taataaccat actatcatta tttatgagta taacagtatt cgttgcactg agtgagttct
    12301 ctaatgtatt agatgtatct aggtcagtaa gtaatttaaa agaaggagat ttttccttaa
    12361 caaatgaaat atctggtttt gataagtcaa tactagataa aatagataaa atgaaaaacg
    12421 tcaatcgcac ttcctttata aagtactctg aatacaaaca gggcgaaata gatacagata
    12481 taaattttga aaatagtggt gagatgttaa aaatcattgg aattgatgag caaactttaa
    12541 aagacttaat gccttctatt acagattcta tactagaaga ctttaaaaat ggttctatct
    12601 gttttataaa aaatccgatt gctatttcta caccaggtgt aaaaactaga catacaaatt
    12661 taaaacctaa agataatatc acaattaaca aaaaacaact agatatatat agtacagtag
    12721 ataaaatgtt ctttttacaa ggtaatggct ggataaatgg tgttgatgtt attgtatatg
    12781 attctgttta taacaccttg acaaataaaa acaagttcaa ccagataaat atttatgcta
    12841 aagataaatc aaaattagaa caaataagat tgtctattga acagatttgt gaaaataatc
    12901 ctggctctca ttggatatca tatattgaat cagataaaca acttaaagag agttttaaac
    12961 aaatagaatt tctagcatgg gcagttatat tatttgtggg attgattggt actttaaaca
    13021 tcattaacac aactcataca aatataaata ctaggactaa tgagattgga gttaaaagag
    13081 ctattggtat gagtaatagt agcttatata agatgttttt atgggaaggt gtttattatg
    13141 gaatttttgc tactatattt ggttcaattg ctgggtatgt cagtgctatt attataaaca
    13201 tggcaactat agaaaagctt gattttacta atataccaat tacttcaatt ttacaagcta
    13261 ctattatttc tatacttgca tgtattatag ctactcttat tccgttaaga aaagttaaaa
    13321 agatgaatat aattgactgt atagatgtca atttataact attttacaga taataaataa
    13381 attaaattat caatgactgt ctctattttc ttttaaatct aactaataaa tctttttaac
    13441 tataatataa gctttaaaaa aggcctgtct caaaatagag ataagccttt tttcattgtc
    13501 gaaataatga aaatatattt aacttcacaa aaaaagagtg cctcacgaat taaaaatttc
    13561 gctttgagac actccccttt aatttaaaat atatagttaa atgctatgcc aaaatttcac
    13621 acatgctcca cctgattttg aattttctat tttaacagaa cctccaagct gttccactaa
    13681 ttgttttaca atgtaaagcc caagaccaga atgtcctcct ttagtctgcc tagcttcatc
    13741 tcctcgataa aacttatcaa gagccttttt taaatcttta gagctaaacc ctctaccaga
    13801 atcacaaatc tcataagaaa tacaattttt ttcatccttt acagtaatac taatattacc
    13861 acctgatgga gtgtattgca gactgttgga tatgatatta tcaaaaattc gtgtcaacct
    13921 atccacgtcg atttgaattg gggattgtat attcccctgc attttcaata taagttcaac
    13981 ttccttttga tgagcctgta attcatagtc ttgtaccttt tgcctcaaaa attcaggtaa
    14041 atttatagga acaagattta attgtatatt tgacttttct aagtcagacg tatattgcat
    14101 cttttggaca agagcagcac ttttttctgt attttctctt atcactgtaa gatacctatg
    14161 aagtttttca ttgtcatctg tattattacc aataagtgca tctgtatatc ccaaaataat
    14221 agaaagagga gattttaaat catgtgctag agcttccacc atttcaacac gttcctgctc
    14281 catcttccac tgtgcagata aagagccttt taattcgtct ttcatttcag aaaatgcact
    14341 acaaagttta ccgagttcat tatctgaata atagtcgatt tcaaaatcaa ggtccttttc
    14401 ttttatcttc ttggacgcat caatcaatag atgtaatggt tgattgatat tctttacaaa
    14461 gcgcttagaa agccatctag taaaacccac gatatataga aatggagaaa acagagccat
    14521 tataataact gcaaatacaa atctccctct aatatttgca aaggtgattt tcacttggta
    14581 gaatagaata acagctccct caatctttcc attatcccct ttgattggaa cagtatggat
    14641 ataaccacct ttacgaacag ttttattgat aaaattatta aataattctt cttttgtttt
    14701 aaatagtttt ttggggttag taccatataa aatattgcca ttattatcca caacttgata
    14761 tagcatatca tccccacgaa tcgttctttt taaaccttct tcattcgatt gtgataacaa
    14821 agttatgttt ttttcattga tgtatttttc aattctagga acttgtcgct cataatagtt
    14881 tggtggatag atatccttat ttaaggaatg aatatacaaa tagagagcaa atacataagt
    14941 aatcactgtg gcaactatac tggctattat aataaaaata aaagtatgtc taaattgggt
    15001 aataagggat tgatttttca tttaataacc tctctctctt tacattttat tccacttata
    15061 cccaataccc caaactgtgg aaatatattc tttttctggt gtcacagcag aaaacttagc
    15121 tcgtattttt tttactcgtt caacaacagt tgaggaatca ccttcagaat cacaccccca
    15181 tactttttca tagatttgtt ctcttgagaa aacttgtcct gcatggagtg ctagtaattc
    15241 aacaatatca tactctattt ttgttaaatc aatattctta ccatcaattt taattgcacg
    15301 ttccttcata tataagcata acttcccaaa atacaaagta gatctcttgt tctcttcatt
    15361 gatatactgt gaacgctttt ccctacgcag attagcttca atccttgcca taagttcacg
    15421 cagtccaaat ggctttgtta cataatcatc ccctccaaag gtcaaccctt tgattttgtc
    15481 ggtttctgat tgctttgcac ttaaaaatat aattgggcat aaaacatcat ctctaattgc
    15541 ctgacatacc tcaaatccat tcattttagg catcataata tccagtataa taaggtcagg
    15601 ctcctgtttt gataactcta tacctgcctg accatcataa gctatcaaca cttcatgtcc
    15661 ttttgccttc aattcatcct caagtagcat tactaggtcc atttcatcat caataatcaa
    15721 tattttactc aatataacac cacctttctc ttatgggaag gtcagtatta aaacaatatt
    15781 cgtctactaa taacttttcc ttccctccca cattttaaac caaataacgc ctcctatcaa
    15841 gaatataatc aaacctattg ctactactat aagctctata ctagctgttt gcatcacttt
    15901 agagtaaaat gcctcagttg aaatagttcc agcttcttta ataaaataaa ttcctggaag
    15961 catacctagt tttactggcc atgtccatgg aacaaatgcc catacttttt caccaacgct
    16021 agttaatcca agtattgctg ccatcaaaat tccaccgata ctaataccaa tagatgcacc
    16081 cataccccat gcaaaactca cccaaagatg aatagctaat agtggaagtg tcccaatcac
    16141 cacaagtcct gctgctgaca ggaataacca tattgttgct ccagatggca ctgcaatact
    16201 cattcctatg caaagtatca acgtagcaat aaatgtgcat atagttaggc aaaacagaag
    16261 aaaaagaaat tttcccagat ataatctaac acgagaaata cctacacata aaaaaccatt
    16321 aaaatttcca gcaagctctt cctcctgcac tataaatcct gctaaaatac ctactccaat
    16381 aggaatgatg aatacagtcc atactgtaaa aaatccttca aaagcaaatt cttgtgtact
    16441 tccagattta gttgtgagat aaaaaaccac acataatgaa aaaataatag gcataaaaag
    16501 agtaagccac tggacagctg tcctctttgc tcgaagccat tctgatgata atagctttat
    16561 catttgtcat ccctcctatt gaaccaagct gcagtaagtg ctgttaatac tataaacaca
    16621 accaaagaaa caacaatccc aataggaatc actgaagtat tcaaaagtgg gtctccagct
    16681 tctaatatag taccgttagg atgtatgttg atgattgggc ataccattct aactgcccaa
    16741 ctccaaggta ctgcaatcca aaatggtttt gtcgcagcaa ggacaccaaa tatcatacct
    16801 aaagctccaa ctcccatact taggaacata cctttccatg tagctagcca tagctgaagt
    16861 ggaagtatag caagagaaac aacccagcat acaatacttg cccctataat ctgtccaaaa
    16921 ggaactggac cagctttcaa tattaaacca gttataattg ttacgactat taaaactagc
    16981 gttgaaataa aactgtagac tgccatagct ataactttat taatccaaag tgtcatagga
    17041 gacacattgt gtgtacgtaa agcacgataa tttccagctt ttttttcctg gaaagctacc
    17101 aaagtagcaa acaatgcaaa tccaataggc agaaataaaa atgaccacca gttaaaaatt
    17161 aatgctaaaa gactttgcca cgcccaagaa gttgtttgag ataatggatt ttgcatgagt
    17221 gttgattgca ttataaatgc atatgctgca aaagacactg ggaaaaaaac aataagttta
    17281 cccataaatg ttcttttata ctttaaaagt tctgattgta aagcattcat ctgttttgtc
    17341 ctcctttaag aataacatct gtaaaaaatt cttctagatt ttcattaggg tcaggcattc
    17401 cttgaaataa tagtcgtcct ccatttataa ttcctatatt atctacaact tgagcaacct
    17461 ctgatagaat atggctagaa agaattacag ttataccttt ttttggaaaa gaagcaatca
    17521 attcacgcaa ttcttgaatg ccaaaggggt caagaccatt ggttggttca tctagtatta
    17581 acaactctgg gtcactcaaa agtgcaatag ctattcctaa cctttgtttc atacccatag
    17641 aaaattgtga agctctcttt ttacctgtat ttttcaaatt tactatttcc aacacttcat
    17701 aaattttatc tttaggtatt cccaatattt ttgtatgtac taacaaattt tcctctgctg
    17761 taaggtttcc atacaatgca ggggattcta ttaaagaacc tatttttgca agagattctc
    17821 gtttccaagg ctttctatca aaaataatac gaccatttgt tgggcgaaga agaccaacaa
    17881 gcattttaag tgttgtggac tttcctgctc catttggtcc taaaagtcca tatatactat
    17941 ttcgttcaat ttgtagagaa acattgttaa ctgccatttg ttctccatat ctttttgata
    18001 agttttttgt ttcaagaatt aaatctttca tattaatttc tcccttcttg taatacctta
    18061 aatctgttac taagagaata ctaacatgaa aaaataacaa ttctataaca cctactaatt
    18121 ttaataaaat ttaaaataaa aaatagagtt accaatttta ttttggcaac tctatttaag
    18181 tttatgtttt acagttatat tagatttaag cttagtttca ttatcacact aacttcaaat
    18241 ttactctata atccttaaat caaacactaa tttattaatc aaacactaat ctattaattt
    18301 atatttcttt agacatctaa tatagtttgc tactaaataa taattattta tatcatattt
    18361 atctaatcct ttaaaagaag ttatttcatc attaagctca tcactacctt ctacaaaaac
    18421 ataacctgtt tcaaattcca tacctacaat aatcttacag ccactataaa tttcctcttg
    18481 agtatcgtac aatttttttg catttccttc atttggaatt gtaaatacaa taggttttaa
    18541 ttctttatca ctggaaatct tttgtgaaaa aggcttgttt aacttaatat tattgataac
    18601 tacatgttta aattcctctg aagtttcttc tactattaca tattttcgct ttaaaaactc
    18661 tattatttct aaaacagact tagaatttac ttttaaaata cttttatatt tttcatataa
    18721 agatttccac tgttcaattt tttcctgtgg tacttcttgg atatgtgtac ttattttttc
    18781 ttgagatatt tttttcaatt aaactctcct ttcaatactt aaatatcctt ataaatctca
    18841 catgactaaa gttacaaggt tcctacttaa tagaattttg catacttaaa tatgtcttat
    18901 taattctcta caggatatct ccgtagttcc tacgattctt acataagtta cttattttaa
    18961 attgttatta gttagattat aaaaattatt tattttatca ctaatataat actcttaaaa
    19021 actttacaaa tcaatttaaa tttgctacct tttatttata acaacttata gtacatttct
    19081 cctatgcttt tcaatatatt acttttaaaa ggaggttttc attatgattt taaatagagc
    19141 tgagcttttc cgaggatatt ctttaaatag atttaacgag atatgcaata tattatcagt
    19201 aaataaaatt aaatataagt ataaagtgaa aaataatgct tactctaaaa aacctttttt
    19261 taatgaaata acacttggca atttaggcca aaaggaagat ttctcttatg agtacttaat
    19321 ttatgttcat aaagacgatt atgaacaggc agagtctcta ataaattcta agttgcgata
    19381 gattatctat aaaacatgac attctgttgt catgttttat atgttattat actttcaaat
    19441 atgctactat attttcaaaa ttgtgtgctt taaaactagc tttttttagt aatttaaagc
    19501 ttaaaactaa ggagactcgt tatatgaaaa taaatataaa atcaaagtta agtgaattta
    19561 ttaaacagaa caatcttttt gatgacagca gaataatatc ctatcttcct aatataacaa
    19621 tagaaacaga caaaataaaa actataatga ttaatgaggt tgtcccaact aacaccaatg
    19681 acgattttta tagtgtagat aaagatgctg attatttaaa aactactatt cctttatttg
    19741 acagtgcagg aataaaagta tctaacataa atgatatcct agatatgggt atctatataa
    19801 ctaatgcagt aaaacttcct aaatcagaat atacaataac tcgtgataca attaaattac
    19861 atatgcctat tttagaagaa gaaattaaat tatttaaaaa cctagaggta gtaatgttaa
    19921 tgggagatgt tgcaaaaaaa tcttttaata tgattactaa aaagcatata aaaaagaatg
    19981 tcatcccttc catttcaaca tataaacttc gtaataatga actttattat gataatttaa
    20041 gagtatttcc atcatatatt atgactggtg gaaacatact gattgaaaaa tcaaaatttg
    20101 aaatggcatc agaagatata aaaaaaatgt tcgagattat aaacggttga tattacaaaa
    20161 taataaaaac taatataaaa taaaaagtgc ctcaaaaact tctatttatg aggcactttt
    20221 attttatatt agtgtaacta tatactatta acataattta ttatttatat tgttcctttt
    20281 aatctctatt ccatttagtc taggtaacat tactctttac aagattactt tatatttctt
    20341 ttatatctct aacgttttta tttaataaaa caattattaa tacaagtcaa atatatctat
    20401 ttatctaaaa atatatcttt tacagtaata tctggatggt gatacttctt cctattcgtt
    20461 aaaaaagatt tttttacatt aatagcctct tttggacacc agtgaaaaca agctaggcat
    20521 ctttcacact cattacccca ctttggcttt ttatcaacta tacttatatt ctctacagga
    20581 caaacccttt tacatgtccc acatctatta catttatttt ctgcaaaaaa tttagtagtt
    20641 gcaatttgca tattcttacc tactaaacga agtacaacac tatctatatg tgactttaaa
    20701 ttgttttttc cttctatatt tccaatctcc aagttattga tacattttgc aatctcagct
    20761 accctattag tctgattttt caatctttct tcttcaacat ctggaggtgt tatcaaagca
    20821 tttccaggca tattgattaa aaaaccagca gataattttt tccccctttt tttaagtaac
    20881 ttatctatag taaataaact atgtccagct accccattac aagtggcaat ggcatatata
    20941 tgagtattaa tattaaaatt taatttctct acaaaagact ttactatatc aggaacatca
    21001 gcaaaataaa caggaaaaac aattaccaat atatcttcat ttatgtctat attattttct
    21061 tttctatgta tagctaaggg tataacttct ttacttccat ttaacgtttc ttttaaaata
    21121 tttgaaacta ctagcgaatt tcctgttcca gaaaaataat aaatcttact attcattctt
    21181 atccctcttt ctatatttct acatcatcaa tagttaaaaa gtctcttaaa ataggattta
    21241 tatttacttt ccaattctat ccaaaatatc agtaaacaaa ggcaattctt catcagagat
    21301 agatttaaat gtctctgttg catatatact tgcaatttca tttaatggtt cttctaattc
    21361 tctacctaaa tctgttagga atatttgaaa cttacgtcta tctttaacat ctactttacg
    21421 gacaattaat cccttatttt tcataacatc taagattctt gtcgtattag atttatcctt
    21481 acatgatttt tcacataaat ctatctgaga aattccatct tgctcccata gaaaccttaa
    21541 taacgcataa tggtcagttg ttatatcata tccattttgt ttaaacatct tttttaaatc
    21601 atcttttact tttaacgaag tacttactaa cttagttgta gcttcatata gtttctcaaa
    21661 atctttcatt ttacctccat ttaaataatc ccttgctcct cccatctatc aattattccc
    21721 ttatattgct caatatcttt aaaagccatt ggctttaaaa cagcatttat agcaataaaa
    21781 ttatagattt gagaaagcac aggtggattt ttcttttcct ctatgcaata aataaatttt
    21841 ttagatacct tttgtatctt tgattctact ttttcagtta taggattttg attaaatcca
    21901 gtttttatag ataaactacc acaaacataa cctcccgaat ctaagaccat ggattttata
    21961 aaagaaattg cttttgaacc acgtgcattt tcatatgtag taactgctat acatggctta
    22021 cgatacaata atctttcaag catcatatgt gctctatctg taaacacctt gaaaagtcca
    22081 gttacactac ttccataagt tgggctacca aatataacac catcactctt agtaattata
    22141 tcatgaatat actctacttt atcattttga ttgatacact tgcccatttt ataacaattt
    22201 aaacaaccaa tacaatatga tggattgacc tcacttaaat caaaataatt aatttttaca
    22261 tctggtatta atctttctat atctttatac aagtaagtca aaacttttga tgtagctcca
    22321 ttttttctag ggcttccatt tataactgta attatcattt ctatatctcc tttttagttg
    22381 ttatatcaac aataagtata tcaactatat ttttagctgt caatataaac catttattta
    22441 aagctatact tacacagctt aaataaaagt tttatttaac tacatgtgct tatttaatca
    22501 actataaatg aattattttt aataattgac aaactaaatt aatgataata tactttatgt
    22561 attacaaatg taagtagaag gaggtatagt atgaaaaagt taccacatat ttcagaagca
    22621 gaatatcaag ttatgaaaat tatttggaaa tatgctccta tcagcactac tgaagtaatt
    22681 gaaaagttgg tagaaacaag tacatggagt cctaaaacaa ttcaaacaat gttattgaga
    22741 ttagttaaaa aaggagcttt aacatatgaa aaaaatagca gagtattcgt ttatactcca
    22801 cttgttaaag aagaagaata cgtagctaca gaaagtagtt cttttttaaa tcgtttttat
    22861 aatggtactc ttaattctat ggtactaaac tttttagaaa atgataaact atctgaagat
    22921 gatattgagg aactgagaga aatcttaaat aaaaggacga ctaaggggga taaataaata
    22981 tgtatgcccc attctttata cgatttttac tcagtacatt aaccttatca atattaattg
    23041 ttgtaatttt acttgccaaa aaagtattta aaaaacatat ttctgcaaag taccaataca
    23101 atattggatt tatattgctt ataatgttaa taattccatt tgtccctctt aaatatatta
    23161 atcttggaaa tgtatttaac tatttatata cttttaatca acttggaagc agtactaata
    23221 ggacttctat gataaaaaat agttcaaatt ctgtaattaa taactcaaat gcattaaacg
    23281 atttttcagt atccctaaat caagttaatt ttgatagttt aaatatttta ttactaatat
    23341 catggataat tggaatttta atcatgatag ctattactat tcattgcaac attaaaataa
    23401 aaaatatgaa aaaatcaata caaattttaa aagatgagga gatagtattt atatttgaaa
    23461 agtgtaaaaa agatattggt ataaataagg attttatact atgcaaatca cctattataa
    23521 atacacctat tacatttgga tactttaaac cacacattat attaccagat aagtctatat
    23581 ctaaattatc tttaaaagat ataaaatata tcttacttca tgaattacaa cattttaaaa
    23641 ataaagatat actgataaat tatataatgt gctttcttca aatattatat tggtttaatc
    23701 ctcttgtatg gtatgcattt aaagaaatgc gtatagaccg tgaaattgca tgtgatattt
    23761 cagttttaaa aaagcttaat aaagatagtc atatagaata tggacaaact ctaataaact
    23821 ttgtggataa tatttcaaga ccatcaaatc ttacacttac atcagatatt ggtggttcaa
    23881 aaaaacaaat aaaaaagcga ctattgaaga taatggattt tcataatgaa tcaaatacgt
    23941 taaaattcaa aagcatttta atttttacat tgatagcttt aattgtattt ggaaatattc
    24001 ccaaactatc tattatggca gatatcaacg aaaaatatag acctacaaat gaacaaactg
    24061 tgtacgagga cttaagtcag tattttaaag gttttgatgg aagttttgtt atgtatgatt
    24121 taaaatccaa gcaatatcat atttacaata aagaaaaaag taaaacaaga atttctccaa
    24181 attctactta taagatttat agtgccttat tgggattgga aaatgggata ataacaagaa
    24241 ataattcaca tatcccttgg gatggaaagc atcattctaa tagttcttgg aatgaagacc
    24301 aagacttatt ttctgctatg gaaaactccg taaactggta ctttcagact ctagataaaa
    24361 aaacagggct aaaaaacata caaacttatc ttaggcaaat tggatatggc aattatgatg
    24421 tttcaggtgg tatctcaaac ttttggctag aatcttcatt aaaaatatca cctattgaac
    24481 aggtagaatt acttgaaagt ttttatacaa ataagtttaa atttgaagat aaaaatatag
    24541 aaacagtaaa agattcattg ttaatatcaa aaaaggatgg ggtatcactt tttggtaaaa
    24601 caggcactgc caatataaat ggaaaagatg taaatggttg gtttataggt tatgtggaaa
    24661 aaaatgaaaa tacttatttc tttgctacaa atattcaaag caaagattat tctaatggta
    24721 gttcagcatc taagataaca ttatccatat taaatgacaa aaaaatctat aatccttaat
    24781 atatttactg tacattctaa aaaattcaca taattttcat attaattatc aattaaattc
    24841 atatacaagg cttattatat aaacatagaa gatagtaaaa ctagcttaaa aacataatat
    24901 aataccctat acaaatagtg gcaactctcc ctcacatcct caattgttgc cactatttaa
    24961 ttttttgtat gaagttaaat atattttcat catttcaaca atttgggtgc aatacaatct
    25021 ctattttgaa acaacctctt taattgtttt agagtttatg aattatttct catactttaa
    25081 aaagattgaa ttactcttga taatcttctt ttgtagtcat tacatatcac ctactactca
    25141 acacatattc tttgacctat ttttacatcc ttgtttatat ccaaaatatt taccttctta
    25201 ccatctggaa acaataccat tgtcaaagta gactttccta attcatgtat tctctttaaa
    25261 tcaacattaa caagaacgtc tccctgttta accatatctc cttgtttaac agcaacatca
    25321 aagccatctc catttaatgc aactgtatca attccaacat gaattaatac ttctccatta
    25381 gttcctttaa tcccaaatgc atgtccactt gaaaccactg tttctaattt acctgaaata
    25441 ggagaaacaa tttttccatc tataatatca atagcaaaac catcacctaa cattttttta
    25501 gaaaatgttt catctggtac attttctaat gcaacaattt tccccttagc tggagacaca
    25561 aagttttcat tattttcatt aaacactaat tcttcgtctt catcttcatt tatagcttct
    25621 ttaggcactc caaataaaca tgttacaata aagcagaatg caaccacaaa tattgatact
    25681 aataagtatg tgattaaatt atatccatca tagatataca ttaaataaga aggtaaaact
    25741 gctaatccat atgaattaga ttgaatatgt aaaattgata atattgctgc tcctaaacct
    25801 gaagatgcac acataataat caaaggcttt aaattatatc gaagctgaat cccaaataaa
    25861 acaggctcac ttataccaaa aagttgagat agcattgctc caaccgcagt ttgtttaact
    25921 tgattatttt tagatttttt cataaatgct agacatgttc caatattcgc aaatccatac
    25981 attgcacaaa gagtaataag ggcattaaat cctgtatttg ctaatagtga tgtttcaatc
    26041 attacataag tatgatgtaa gccagtaata acagctaatg gatatgtaaa tccaataata
    26101 aatcctccaa ttcctaaagg caaatcaatc aataagctga tgatatcaac catttttaat
    26161 tctattgtat gcattatagg gcctacacct aacaaaataa ctaacattgt tattagcata
    26221 acaaaaaatg gtgtgaaaat aaggtctaat acattaggca tatgtttacg gaaccatttt
    26281 tcaagattag ctccaataaa tgctgtaaca atagctgtta aaacacttcc ttgacaacct
    26341 acaataggaa taaatccaaa tgccataatt gcttcaattt catttgatgg gtcagcaaca
    26401 gaatatgcat taggaagtat tggggaaact aacataagtc caataacaag tccaataaca
    26461 ggtgttcctc caaatacttt aaatgctgac catacaataa ttgctggtaa aaaagcaaat
    26521 gctgtttctg taagaaccga aacaagtgtc tgaatataca atggaatatt tgcagaagac
    26581 attccaaata atccaagtac attatcatta aacaaacaac cctttaatcc caagaataat
    26641 cctgttgctg caataactgg aataatagga acaaatatat ctgctagagt tctcataact
    26701 ttcttaaatc cagtttcatt atttttaact aattcatctt gttctttttt tgataaagtt
    26761 tttaatccca ttttttcaac ttctgcataa actttattaa ctattcctgt tcctaaaata
    26821 atttgatact gtccagaagt aaagaaaacc cctttaacct catcaacttt ttcaactttc
    26881 ttatcattaa taatttctct atctttaacc atcactctta atcttgtggc acaatgtgta
    26941 atagaaataa tattatcttc accaataatt ttaataagct catttgctat tttattatat
    27001 ttattcattt ttctacctca ctttcaataa tactgcatga aatggtttca aacgcactgt
    27061 tttatttaat agatttatat catctaaatt ttggaataca atatcatatt tttcttctac
    27121 tcttatttct acaggtttat cagaaaaatt ataataacaa tcaataacta ccaaatctaa
    27181 ttgccttcta tacgcaataa tatcatcact ttctatatca ataggttcta ttgaaccata
    27241 aatcaaacaa tcagaatact cactatcttg tctcaacttt atcatctttt tataaaattc
    27301 taaaatactc tctgaattgt taatctgact ctgtgcatta atatctttat aattttcaat
    27361 aacctttaac catggtgttg tatctgaaaa acctgcattt tctttatctg cccatggaaa
    27421 tggcgttctt gcattatctc ggcttcttaa attcacaaat tctaacgctt cttcttctga
    27481 gtaactttca tctattgaac gatagtattg gtcaatgcta gataaatcat taaaatcatt
    27541 tatggtatct cttttaaaat ttgtcattcc taattcctgt ccctgataaa taaatggggt
    27601 tcctcttaaa aagaaataca ttgctcccaa catttttact gcatcatcat tcctttcgta
    27661 ttgcaaaaga tactttgttg tagctcttgg ttggtcatga ttttcaataa aattagctgc
    27721 ccatccatgt tcctgaacat acatttgact atctaaaatg cattttctta aatctggaat
    27781 tgtccatgaa attcttttaa accactcact accagaagca acatctaagt cagcatgttt
    27841 aaagtcaaag accattgaaa agaaaccatc ttctccaata aaatcaccta gctggtcata
    27901 gctaatacct gctgcttcag caacagtcat acaatcatat tttttaaacg tattttcttt
    27961 taattcataa agcatttttt ctattccagg ctgatttcta actgtttttg tacatttaac
    28021 aagaccatca acaccatcac tttctaaact ttgaaaactt aaattctttt tgatgaatgt
    28081 aatagcatca actctaaatc ctgccactcc catttgagac caggtattaa tcatttggta
    28141 aagttcactt cttaatattg gattttccca attaaggtca ggttgttttt taccaaaaga
    28201 atgaaaataa tattcgtctc tattctctac cttttcccaa acacttccac caaaaacaga
    28261 cctccagtta tttggtaaat cgtttccttt tttaaaaata taataatcat gataaggact
    28321 ttctggattt tttaatgctt cttgaaacca aggatgttca tcacttgtat gattaagaac
    28381 taaatctaat ataattttga ttcctctatc tttactttct ttaattaact cttttaaatc
    28441 ttccatactt ccaaattcac ttgcaatatc caaataatca ctaatatcat acccattatc
    28501 gtccataggt gatttaaaaa ttggacataa ccacaatgat gtaataccta aattttttaa
    28561 ataatctaaa cgagaaataa ttccctgtaa atctccaatt ccatcattat tactatcttg
    28621 aaagcttctt ggataaattt gataaacgat ttctttttgc caccatttct tttccataaa
    28681 ttactccttt ttatatgata tttcttcttt ttaattcttt ataaattcca ttatcgaata
    28741 tgtcctcaca tatagatgtc gctatatctt taagttgttg atgactattt ttcattgcaa
    28801 ttgtaacgtc tgatgcttga aacatgacaa catcgttttg accatcacca aaacatatgg
    28861 tttctttttg agttactcct aatctttctt gtaatctctt aattgctttg cccttatgaa
    28921 aatctttttg aataatttca taatactgac tagaaatatc tctctgtgct aattccattt
    28981 tatcttgtag tatatttttc acttcgtcaa ataccttttc atttgaccat aaacaaattt
    29041 tatgtatatc ttgtgactta tactcttcaa tgttattttc atatgttatt ttttcttgga
    29101 tatgttgttt atttatacaa gaattagttc ctttcaactg attcattgtt tcaaatattt
    29161 ctttggcttt ttgattcatg aaaacttttt cctgactctc aatcgaaaaa gcaacttctc
    29221 tcttttttaa taaacaaaca acttccttta tcaatctttg attaaaagat tgattataaa
    29281 gtaattcacc atgatattga atgtaattac ctcctcctgc aatatatcca tcaactccta
    29341 atgataaaac atcatcttgt attgtaccca tacttcttcc agtacaaata acaacactgc
    29401 aatgattctt ttgacataaa cgtatagcat gctttgcaga ttctgggatt ccatatacct
    29461 catctctaag cgtaccatct atatcaagta ttaataattt gtacaatttc atcttccttt
    29521 cttactatca aaatcataat agcattcaaa aaaaaagata tcaatatttt gatatctttt
    29581 aaaaaatatg ttcattttta gcacaaattt tcattttcgg ggaatatgtt cactttctaa
    29641 atacatcttg tatttaatat aaagcagttc aattaaaata aaataaggtg ttgttacatc
    29701 gtagtccagt tgtttatcta cagaaataga tatagattga atatacaggt tttcatcaca
    29761 taatcttgct aaaggattac ttatcatttt tgtaatagaa accatataaa ttcctttcat
    29821 tctcatttct ttagcaaaat caataattgt agatgcatct ccattcaatg aaataaagaa
    29881 aatcatatca tctgttttta taaaatgatt aagtgcctga atcatatcat aaccataaac
    29941 atcatatata attttccctg ttggtaagaa aatccttttc atctctttag caactctttc
    30001 ctgagaataa ccttctccaa agacgattat acgatttgcc tttttcattc tttcaaacat
    30061 aatcgaacaa tccttcttct ctatatcatc tatcacctta ttataacaat ccattaattg
    30121 gtgtttactt tgatttttat attctacttc tgtttcattt aagcgtataa taactcttaa
    30181 ttcactatat ccaggtaatt gtagtttttg agcaaaacga gaaagtgcac ttgtagatat
    30241 atggtatttg tctgcaaatt catctataga aagtttaata caatcttctt tatgattaag
    30301 aatacactca cagatatact tatcatttgc tgtaaatgaa ttataatatt tattgaaaag
    30361 tccttcaatt ttcattcttt tctccttcta tactctatgt aattcatatg aagcaaatct
    30421 aatagagcat aaaatgctcc tacgacttca taagatatag cttgtaatgt atcaagtttt
    30481 tgcgtttcaa catacagatt atactcacaa agtgttgcaa ttgtattatt atcaagccta
    30541 gttaaagaaa tcgtatgtat atgattgttg ataaattttg caatttcaat tcctgctttt
    30601 gtttctccag acaaagaaat gataataaat aaatcatttt tttgaaatga ttctctcata
    30661 aattcaattt cacctatatc aaataagtca ataacacatt tacctactga aagaaatatt
    30721 ctctttattt cttgagctaa acttttctgt tcattacctg tcccataaat ataaattgtt
    30781 tctgcatcat atattatttt acaaatatct tgaaatgata ttttttgtaa ttcattcatt
    30841 aatagtcgat aattctcgca aacatcatga aaattattat cattattaac aaattctagt
    30901 tgattatttt taagtaaata ctttaaatca gagaatgaat ctaatccaat ttttctacaa
    30961 agccttaata aagtagctct agaaacatta cattcatttg caattttttc acacgaaaaa
    31021 ttacggtatt ctctttgaca aatcaatatt tgtttaataa taattttatc attttcattt
    31081 aaattatcat aattttggtt aactaacgat tctaatctca ttttttccac tccctaaata
    31141 ttattttaat atacattagt tgctttttct agggaagagt tttaaataat aaggataaaa
    31201 taatcatttg attttatttt tattaaaata aaaataacct gctaaaagca ggcaccaaaa
    31261 agtacttatc ctttcgaaca tgtactttag atattgcttt cttcggaagc ttcatctctt
    31321 catactctaa aatatagttt tttctaactc aaaagtattt tccatggtag aaattacttt
    31381 aattcatctg ccatttactt tttatcttat ttaataatta ctattacttg aatatttact
    31441 tctttaagta aatttcatag ttaacaaagc taaaactatt attatagatg ttaaaataca
    31501 aaattgtaag tattgttata aatatgctta cagctacaaa tatacatgat atattaaaaa
    31561 gaagctgtaa attattatca tacatacaag caactatgcc tctattaatc catgttaatt
    31621 tttattattt aatacaagga gttccatgag acatacatat ccattcatat tttaaattat
    31681 ccaattctct tatagatttc accatctttt tataatccca attccatgga ttaggataag
    31741 gaactatatt tccattctta tttttgacta aatcacctgc aaataataca gcttcaaaaa
    31801 tcatgcagac atgccctgga gtatgaccag gagtatggat aatttttata ttcccaatct
    31861 gcatattctc tccataaggt tcaacatcct taatgagcct tctggaaatt gcctttccaa
    31921 taaacttctt aaacccaggt ctatccttct ctcctataat aaaaggtata tcctctacat
    31981 gagcccatac ttttgctcct gttttttctt tcaataattt aatattagat atatggtcaa
    32041 catcatgatg agttaataaa atatgcttaa tatctgtaag tttaatgcca agtgttttta
    32101 attctttaat tatatttttc cccataaaag gaagacctgt gtctataaga ataatttctt
    32161 tatcaaacac aataaaacaa tttgagccac gagtactatc taacattaat acattttctt
    32221 ttatcttcat aaataaattc cccttatttg gtattttacc tatataatta attaataaag
    32281 ttataaatag ttataatact tgatattaat tttatttttt attaaagtat actataggta
    32341 tacaagtatt atatttacat aagtatacca tcagtatact tttttatcaa tagaaaggaa
    32401 taatttatat gtcagaatta tcaaaaagag ataaagaaaa aatacaaaga gaaaatgaga
    32461 ttattgataa agcagaaaaa ttattttgtc ttaatggatt tgataataca actatgaatg
    32521 aattagcaaa agaagttgaa tatactaaac gcaccatata caagtacttt tcatgtaaag
    32581 aagatttatt ctttgctgtt gtcttaagag gatataaaag actttgggat aatgttaaaa
    32641 tagaaagtgc aaaaggcaaa acagggtttg aaaaaataaa actttcatac tttgcttttc
    32701 ataaatttta ctctgtagaa ccttctctat tatgccttat gggaatgatt ggtattgtaa
    32761 actctgaaaa atcggatact gatatgctgt ttaaagaaaa gtttttttct tttaataaat
    32821 ttatgtttga tgaaatacaa ggaatgtttg aaattggaaa aaatgataga agtattaggc
    32881 atgatattga aatacctact cttatgtatt catcaatatt tacacttaca ggatttttta
    32941 atttactatc tgtaacagga aaatcatacc tgaacaactt taatatagat gaggaaaaat
    33001 ttattgaaac aactcttgct cttttaatag attcaattaa agcataaacc taagtttata
    33061 aattaaagtt tatatactta aatgataatt ttttctatct ctaatataaa aaatattaaa
    33121 cataaaacta ataacttagt taatggaata actaaattac tgaaaggatt aaaagtaaat
    33181 ggctaaaata cttcttttag aagatgatga tacaattaca tttggaataa aaacttccct
    33241 tgaaaagaaa aatcacactg tatgttgtta taatacgatt gctgaagcta aaaaaaattt
    33301 tgataaaact attgatttaa ttctgcttga tttaaatcta cctgatggta ttggatacga
    33361 gttttgccaa tatgttaaaa gtatagaaga tactccagtg atatttttga cagtccgtga
    33421 tgatgaaaaa gacattatac gtggattaga tatgggtgca gatgactatg tggttaaacc
    33481 gtttttgctc tcagtacttc agtccagaat taatgcagtt cttagaagaa ctcattcaaa
    33541 tactaacaat actattacat gtgaaaatat aagcttgaat aaggttgaag tcaaagcata
    33601 tttagataat gttgaagtac ctttgacagc aggagaatat aaacttcttc taagtcttat
    33661 ggaaaataaa aatagagcta tgactcgtac aaagttacta gaaatgctct gggatgtaga
    33721 tggtaatttc gtaaatgata acactcttac tgttacaata aaacgtctta gagaaaaatt
    33781 aaaaaatcca ccttgtataa aaacgttaag aggcatagga tatagaatgg aggacagcta
    33841 gtgaaaactc caagaaatat caacagtaca gttgttttta taatattctg cttaattgta
    33901 acttttttat tgagtgtaat tctaacaact ataacttctt ttaatgaata caatgtactg
    33961 tctaaggctc ttggtgcatc atatgagtac aatcctaagt ctacagaaag tatactaaaa
    34021 tcactgaaaa attctagtga taaggatttt aaaacaggaa atgaaatttt atcaaaacat
    34081 ggatattcta aaagtacatt ttggagtaaa aacttttttt attttctagt gatatcgttt
    34141 ggtataattt caacaatggc tacagttata tatataatca aacatagaac aaataagcaa
    34201 aaactgagta gaataaacaa tcttactcaa tacttagaag aagtgaattt aggaaaagag
    34261 tctgtacttt tacgatgtga agatgaattt tctcaccttg aagatgagat atataaaaca
    34321 gttggggaac ttcgttgttc aaaagaattt gctttaaaag aaagacaaac tctttcagat
    34381 aatcttgcag atattgctca tcaacttaag actccaatta cttctatgtc acttatggca
    34441 caattacttt cagaaaattg tccagatgaa gaaatagatt atattaacag acttacaaat
    34501 caaatctcaa gacttgagag actagtttca tctttactta cattatcaaa attggatgca
    34561 agtactttaa tatttgaaag caaacttata gatgtacatt ctcttcttac ttatgcaatt
    34621 gagcctatag aaggttcttt aagagaaaaa catcagacat ttactatcga ggcttctcct
    34681 tcggtagaat ttgaaatcga tattaattgg actttagaag ctcttttaaa tattcttaaa
    34741 aattgtagtg agcatataga agatggtgga tatatagttg cttattatag tcaaaatcct
    34801 ctatatgttg agattatcat agaagataat ggtaaggggt ttgctcagga agaacttcca
    34861 tatattttta atagatttta tcgtggtaaa aatgctagta aggacagtat tggtataggg
    34921 cttgctctat caaagtctat tatagaacgt caaaatggta ctctacatgc agaaaattgc
    34981 cataatggtg gtgcaagatt cataattaaa ttttacacat aaaatgctgg attataggta
    35041 aaatacctat aatccagcta tatctatatt ctatgttatc tattgtttta gtaatatact
    35101 tctatttaca tttaaggttt tattaaacaa acaacttaac tatccctata cttgtaagta
    35161 gtcttaaatc gaaaccttta aataagttca aatagatttt gtttatattg tttcattttt
    35221 tatagattct actatatttt cattcttcaa ctgcttgtat cctgtcatat atgatgctat
    35281 tacaataaaa agtatcaata tagtaaaacc tattattgta gatataggtg caaatggtaa
    35341 atactctata aaatatattt catttatacg tagaaaagca tacactattc ctatttgcac
    35401 aggaatacta agtagtaatg gtgtaattcc taagaataaa ccttccaaaa taagcatctt
    35461 ttttatgcct tctggagata atccaacaga acgcaacata gcaaactctt gtcgtctact
    35521 tctaatattt cctgacactg tagcaagtac atttgataat ccaatcatag ccaataaacc
    35581 tgtaataaag cctactatta aattcatggt ctttattcca ctagcctttt gtttttcact
    35641 ttctaaaaca tcctcaatac tataatctcc tgaaccatag tctttattat aaatggactc
    35701 taatttttct cttactctag gaatgtcctc acgattattt actttaaata ctcctatcag
    35761 cctatttgaa cgtaacctac ttacttcatc ataattttta gatatttcct gtaccataga
    35821 cattggaact atttgcatta atgtatactt tgaactagta tctactattt taggaagtgt
    35881 gcttgtaata gctcccactt tcatgttgta agtataatcc cctttatctt cgtcatatac
    35941 tttttcattt aatttaatgt tatctcctat tgaaagattt aaataatcta tatatacttt
    36001 atttctacgt gtactacgat taatatcttc ctccttatta tatacaattg aggttggatt
    36061 ttttgtatta taaaataact ttgggtctac agaaatttgc ctacaatatt ctgtaaaact
    36121 cttatcatca agcccaatta tatttgaaat tatacgaaac ttgccatcac gttctatagg
    36181 agagtatttt ttagatgaaa ctatactttt aaatcctcca tttttcgcaa gttcttttga
    36241 tgcatctttt tcagtcagcc aagtggaagc agacattttt tgataatata gtgaactttt
    36301 tacaccttct gtattatcta atttttcaat gaaagcagac tctataggtt cactattttc
    36361 caaataaact gctatatctc tttggtcctt ataattatca cttccataaa cagcttttgc
    36421 tccttcttga tttgcaatta tatgcaaaaa acatgtaagt aataaaaaag ataatgttaa
    36481 agatattgtt gcagtacgat aagatttttt acgagcacgt agtgcgtttg atgcaagttc
    36541 tccttctatt ccaaatatct ttcctaatga atatttatgc gactttttga ttttaacact
    36601 atctccttgt cgtattgctt ctataggaga tatctttgat acttttcgtg ctggtataag
    36661 tgcagaaatc cagactgtta ctattgtaag taaaactgct ggcagaaaag caggaatacc
    36721 ataagtaaat accacttctg gaacatcagt atgataatta actgaattaa cataaactat
    36781 aagcctatta cacaataacc atcctaaaaa taaacctatt ggtaatggta taattgtcag
    36841 taaaaagcct tcaaacacta cagacctttt aatttgtttt ggtgatgcac caacactaga
    36901 taatatccct aactgagtaa gtctagcatt tgcagacagt gaaaacgcgt tgtaaatcac
    36961 cattacaaac acggctactg taaaaattgc tattgtaaga tacataatag gagttgaaaa
    37021 ttttgatata ctactcatag atgctttctg ttctggtgaa aagactaaca tctttaaaag
    37081 ataattacta ttgtatttaa gattgtattt tccatattca ttagtcttcc atcccaatga
    37141 tttagcaagt tttggaagtt ccttatacgt gtctcttata tttttaaatc gcaagtacac
    37201 agttatacta tcattaggtt ttatacttgt tttatcaaga tatccaagag ctgtatatgc
    37261 aggtattact gatgaagtag aaacatctac ctttcctact attgtcaatg tagcctctga
    37321 aattttttta aaactttccc ctttcgattt tggggctatg ggttcaagag gctttccatt
    37381 taagattcta tatcctattg ggagagtaat tttatcacca atttttacac ttggattatt
    37441 ctcaaaatat tgttttgata atgcaatttc attagcatta tttggtcgac gaccctctat
    37501 tatagtatcc ttttctggca tagaattcca atactctgat gtagcatttc tataaattat
    37561 ataatctctt ttctcatcat taattttgcc tacataccat tgtcctttta ccattacatc
    37621 atcaactgaa gaaaaatttt caattaatgg taagtcactt ccataagtat agtcaaacaa
    37681 ttcaccatgc cagttacctt ctttctcaat tgaaagtctt ataaaatctg tccacatggt
    37741 atacaacagt ccacacaaag aagacatcat ggttgtagta agtaatatag ctaacattat
    37801 agctatacta ctacgtttat tgcgtcgtac aaagtctaag gtgtattctt gaagaatatt
    37861 catttcttca ccaccttttc agagacaatc actccatctt ccatagttac aatacgattt
    37921 gcctctagtg ctattttctc atcatgagta ataagaagta ttgtctgatt aaatcgttta
    37981 tttgataagt ttaacaagtc tacaatttct tctgaatttt ttctatcaag attaccagtt
    38041 ggctcatctg ctaataaaat agctggtcta tagattaaac ttctagctat agataccctt
    38101 tgttgttgtc cacctgaaag ttgacttgga agatggttta atctatcaga taatcccaat
    38161 atagatacaa tctcagagaa tctatcctca tccacctttc ttttatcaag taacatgggt
    38221 aataatatat tttttctaac atcaagggta ggtataagat tataaaattg ataaataaga
    38281 cctacttttc tacgtctaaa aactgcaaga gcttcttcct ttaaacttga tatttctgta
    38341 tcttcaacat aaatctttcc agatgtaggt ctatctactc ccccaagcag atgtaacaat
    38401 gtagatttgc cagaaccaga tgctcctaca atggatacaa aatcaccttt ttgaactgat
    38461 aaatttacat tattaagggc tgtcactctg gtttgatttg aaccatatat ttttgtgaga
    38521 ttttcacatt ttaatatttc catatacaat catctccttt atggttaaat tttagcaacc
    38581 taaaatgaca ttatagtgac atgaatacaa atataaatta ctattaaaaa tattgtttag
    38641 tttttgcaca ttatttaaaa ttataatata aaacaaaaac tatgcaatat attttattta
    38701 tacttttaat atattacata gtctttaaaa ggtattaact ttaaatctat aggtattcaa
    38761 tttaataatc aatagcaagt attttatgta ctaaaggagt tttgctctat atagactcaa
    38821 tttagtaaaa ttatttaata aatattacag actataggta aataatattt acaaataaaa
    38881 ttaagtttat tcccttacac tataatattt cttaattata ttaattgcaa tttcctttac
    38941 ctttggccct gtaatttctt tattggaatc atctgattta atagcaaaat aataggtgtc
    39001 accttcacgc tctagcatac caacaaacca tgcatccaca cgtttatttt tttcatcaaa
    39061 tcctgttcca gtttttccat atacatttat gtttttatca tttatatcta ttttcataat
    39121 atctcttaaa atattaatat gctctttttt aaagtttgta tctccctcaa atatttttgc
    39181 cattgtttgc acttgttctt ttggagatat ttgtaatgaa gattctaacc aaaatccatt
    39241 taaatgtccc tttccatttt ttaaatcgcc ttcccattcg ctaatatcgc aattcccata
    39301 ctttaaatca tctaaaatgt tttggacaga tttagcatca actttatcta tcaatttttt
    39361 gtaataccaa acacaagact ccttaaatgc ctcttctaaa ctaagatttt tattccaatt
    39421 tttatttgga tactctgtac catcatatcc cataactgat tcttttgagt ttattacccc
    39481 tttttctaaa ccaattaaag ttgaaactat tttaaaagta gaacatggtg accttcttgt
    39541 ttcaattaat tctttgttat atatattata ttctttattt ttagtattat aaaaaatagc
    39601 tcctccacta ataccttcaa aacaatcact atagtcaacc atattaattt tttctttttt
    39661 gtttttatca ttgttttcaa ttttggattt atttaattca gacttattta attcagattt
    39721 tatataattc ttatcagttt tttgatttat atcgttatgt tttttcccta cataatacat
    39781 taccataact acaccaacca ataagatagc tatccaaata aaattctttt ttcttttcat
    39841 aatttatatc atctcccata tttaaattta taacctacta ttaaaatagt agacattatt
    39901 tgtaatatac tccaatctag gttctactta taagaaacaa gactaaatga atagctgtat
    39961 ctcttatatt ttcttcacct agtacaatta tgttgattaa acctattgcg aagataatta
    40021 ggtaactatt aataacatcc tgtcctcctt ttaatttgtg atataataat tgattccaca
    40081 tttaaaactt actattgtaa tatttaaata ttacaatagt aagttttaaa tgtcaagtta
    40141 gtttaggaaa gttattttaa ttgtataatt gttattacat ttataaaata tggcatgttt
    40201 aaaattattt tgctattggg aggattaaga taagcagtat tataaaagct ataaattata
    40261 aaatttaata tataatttat agcttttact tttacaaata ttgtttttat tgatttatta
    40321 atgaatttta ttgacaggtt atatttatat aagtaaacac ttacataata agtatataat
    40381 ctacatatct ataagttgag tcaattcaca agtatatgtc aacttaagtt tatgcatagc
    40441 tcgtgtacag gcaatatata acaaactgcg gtcataatca ctataatatg ttttattatt
    40501 tactgaaggt acaataactt catcaaactc taaacctttt gacattttaa tagaagttat
    40561 ggatactcct tttgtaaagc tagaactttc agaagatatt aagtgaacac tatattcttc
    40621 tcttaacgca tcatatacag ctttagcgtc attatctgtc tttaatataa taccaagagt
    40681 cgcattatca ctctttttaa attcttcaat ttctattttt atcttattta tttcatcttg
    40741 ctcgttatta cattttaata aagctggttc ttcaccatgt cgttcaatag gctctaatga
    40801 agatatgtct tgaatctttt tggcgaaatt aataatctca aaagtagaac ggtaactctt
    40861 gttcaacata actaattccc catcattata tagctgtttc atatcatcta gtgtatgagt
    40921 atgattagga ttaaccaatt gtccaaaatc tccaagaata gtctttttac acttaaaaag
    40981 taagtttatt acagcatatt gaataggtgt atagtcctgc atttcatcaa taacaatatg
    41041 ccttataatc ttatcttctt gtataccttc atatgcagca tgaatatata taaatgggta
    41101 tacatctgac cattcaagtg ttttcttttc tgccatcaca aacatgtttg atatattcat
    41161 ttgtttaaag aaatccttat atagtgtaag agtatttttt attgtcaaca ttccattcaa
    41221 acttttaagt atacttttta cctttggtaa atcttcttcc ataatattat ctgattcaaa
    41281 tttataatga atgtcttcag ctaccttctc taatctcttc ttaactggat atctgttata
    41341 tgcctcaaat ctactctgta tccagtcact tttagctgta aaacttccaa aagtgtagtc
    41401 ttttggaata aaaatcttat ttggcatttg ttttatataa tcatcaataa gttttacaaa
    41461 atcaagtgta gatttaaaac gcactctttc agaccattta gcatcattta tttctaatgg
    41521 gtctttctca ctttcaaaat taataactct atctaattgt acctctgcta tattttcaaa
    41581 acttaattca cataatggct cttctccaag ctcaggaagg acattggaaa tatagtctcc
    41641 aaagacttta ttaggtgata ggataattac attatttgct gatattttat ctttaaatcg
    41701 ataaagaaga aaagcaattc tgtgtaatgc tatagatgtt ttcccagaac cagctacccc
    41761 ttgaataatc agtgtatcag ctttatcatt tctaataatt tgattttgtt ccttttgtat
    41821 tgttgaaatg attgacttca ttttttcatc tgaagtgtga ctaagttctt tttgaagaat
    41881 atcatcttgt atattaatgg aactttctag tgcatattct aattttccat ttttaatttt
    41941 aaattgtcgt tttcttgtta tttctccatc cacccatcct attggagcat catatccagc
    42001 ttttccgatt tcataatcat aaaacatact ggcaattgga gaacgccagt caagtattat
    42061 aagctcatct tcataatcaa atgcaaatct accaatataa tacttagatt catcatccat
    42121 atctttcaac ctaaaatcta ttctagcaaa gtatggagaa tctttgattt tattaatctt
    42181 atctcgaact tttaccataa aagccccata gttatctatt tgttttagtc cttgttcatt
    42241 ttgaaacatt tcatgtgggt ctatttcacc acgatttttt accatataca ttttagcatc
    42301 catataatcc ttatcaagct tgtcaacaag attttcagct ttcttaaaag cattgtctag
    42361 cttgttattt atctctatta gatgtgcaat ctcatctgga aaaaaagtta ataactctgc
    42421 atcatattca cacatattat gtttagaatt agatgcaata atatcgcaat ttactacttg
    42481 tttattttca gacatttaaa tcctcctttg ttaattaagt acttacactg aatcattata
    42541 cttaattgtg ttttggagtt tttaatcatt cttgctattt aacttaaagg aagaataaat
    42601 ttttgagtag gatatccaaa ttccacaagc aattctgctt ctgcaaagcc caacttcttt
    42661 atcatatctc tatgtcctgt atcagctttg tcaccctctc gaaaggtagt aattgaaata
    42721 tctgtatcta tcaagaaatc ttcaataact ttcttcaaaa acacttgtgc aatgtctgaa
    42781 ttacgatact gtggatgtat tccaaaaaaa tcaatacttc tagtttctct attaaacacc
    42841 atatttgcaa tagcgacatt attaagtttt aatattaaag ctctttcttc taaaatatac
    42901 tgttctaatt gatatatata ttcttcctct tgcaaattgg gaaatccatc tatgactaat
    42961 ctcactaaat tcatccataa tggtatgtca gacatacttg caagtttaat ttctttttcc
    43021 aactctagta cattctttga aaataggtta tcttttttca aaacaaatct tagctgcaaa
    43081 ggataaaatt cttgttcttt cctatattta tttggagatt ttttatacat agctttaaat
    43141 atagaagtga atgcctgttg actttcatat ccagctatca atgcaatttc aataattggt
    43201 ttctttgaaa ataccaataa ttttgctgct tctgtcaact ttctccgctt tatgtaatca
    43261 tgcattgtta ggccaacaga agttgtgaaa gttctatgca ggtgatattt tgagtaatga
    43321 acagcattag caactatatc taaatccagc ttttctgata aatgctcctc tatatagtca
    43381 atagcagtta tgacattaat tactttgtaa gacattgcag cttccctcct tttatccatg
    43441 caacattata tcaattatta cttagttata tttaatgaat cttgctattt tataaacaaa
    43501 tttgttgttt aagttttcaa ttcataaatt taatatatta ctttttactt tctgattaaa
    43561 gactctaatc ctttaatttt caataacttt tcatttagta aatctaaaaa gttatttatt
    43621 attttcttct tattagattc cttaattaaa tgataaatat ttatattata cgactaaaaa
    43681 cagcttttta caattattta atatgattac aaacttaccc tatcttaaag tttaatgggg
    43741 tcctgttatg aatcttttta ttttaattta agctcttcat cagtttattt tatatattga
    43801 tgtatttgat ttcatacaaa aaagagtgct tcatgaacta aaaagttcat ttttaaacac
    43861 tctcttttat gtaaataaat ttctattcta ttttgaaata ttataatttg acttataatc
    43921 tattaatacc aaaaataata aattgtacgt ctaagaatag attctaatta gttgctcagt
    43981 agtaaaatct gtttttaact aatcctgctt tgtatgttga acatattcta taattgtacc
    44041 atctggatgt ctcaatgtca tattatatcc tgtaggaact tttttcttat ctcttactac
    44101 aactgctcca ttatccaata gataacttct ccattcatca acagaatcaa ccataaaagt
    44161 agattttgtt tctataaatg gtttaagagc atcatcagaa ccagataata gtaaaacatt
    44221 tcctatttgc gctaattcca acccaacttc tttataggaa aaacgcaaag aacatttttc
    44281 ttttaaaaga ttctcataaa aaggtatggc tttttctata tcttgaatat aaaaacgtgt
    44341 taatatatca tatattttca tattttcccc ctatatatct atataatatt acctctaaat
    44401 tataccactc tacaaattat ataacaataa attaagcata gccttttgag catcttaagt
    44461 agaccttaac aatatattgg ggttacatta gaatacataa attaaatcac cttgatatta
    44521 tttaggataa aatttatgta gtagcagtaa atgttcttct aattatcaac taacaaacga
    44581 taatctttaa ctttctatat aatgggtaac atcattttcg taagatattc actagctgga
    44641 cgattgatat catttaaata ctggtaatat atatcgccat gaagtttata tccattgcta
    44701 tttgcccatg aaaataagtc ttctaaagta gggtcttgta attcataaag tcctaaatca
    44761 attgcagtta ttattttctg tgcaggaaca atcttttgta gaatctcatt tttcccatct
    44821 atataagtgg ctacaggaaa ccctacttca acatccaatt ttactaaatc catgttatga
    44881 aaacatacaa tcggtgctcc tgaagataaa attcctctct cctccagata tttagaaatt
    44941 ttttcaaaac tttgttttga aaactctgaa aattctacca taaagtcaat tgtttttcgt
    45001 attgccaaaa aacagtactc agattgttca gctattgtta tattggatat tctagtcatt
    45061 ttattcctcc attactttat tttcatttct aatcttttta taccaaatta tacgaaaatt
    45121 cactgtgtaa ctaattattt catatgaata taaaacataa cctccttcca tttcttatat
    45181 cgaaagtata gcaaaaataa tctcatcatt cttgtcacac agtgctctta taatcagaac
    45241 atacttaaaa gacttgccta atttttaggc aagtctaaaa gaaatctttt tctataaaaa
    45301 atttatacaa acaattaaaa tatcaaaata tagactaata taaaactata aatttactaa
    45361 tctgaacctc ccatggctaa agtcacaaga ttactgattt atagaatttc gcacactaaa
    45421 atatgtctta ctaattcccc acaggctacc cccctagttc ctacgttctt acataagtta
    45481 tctattatca aacatcaaaa tttaaacaag tttcaggttc atcttctatt cttgctattt
    45541 taaacttaca tgcaattaat actaaagata ctattggatt tataatattt aataaagcgt
    45601 atggaccata tgttagtgca gatacaccta atgttgctgt tatatacgcc ccgcatgtat
    45661 tccatggtac taatggagaa gttaaagttc cactatcttc taaagctctc gacaacatct
    45721 taggatgtat acctctcttt ttatattcct tattatacat tcttcctggt ataactatag
    45781 atagatattg ttcacctgct attatattgg taattgtaca agttaccata gtacataata
    45841 ctgttccaaa tacacccttt gctaatctta gtaaagaaga tgctactact tcaagcatac
    45901 ctgttttttc taaaatacct ccaagagata aagcgcatat tgttaaggat acagtggaca
    45961 tcatattcat aatcccacct ttagataata aagcatctac ctcctgtatt tgtgttgacg
    46021 aaacatatcc attttgtgct gcatctaata tcgtattcat agattctcct tgaaaaacta
    46081 ctgcaaacaa tactcccaat acagcaccta ctataagccc tggtatagca ggaactttaa
    46141 atacaaccaa tccaattact attgctggag ctaataataa tactggtgat aaagtattaa
    46201 atgtagaatc taatgtagac ctaattaatt ctatttgttt tatatctagt gcttgacctg
    46261 aatacttcat tccaattaca ccataaatta ctaaacaaat taataatgat ggtatagtcg
    46321 aatatagcat atattttata tgtgtaaaca aatctgttcc tgccattgct ggagctaagt
    46381 tagtcgtttc agataaaggt gatagtttat ctccaaagta agctccagat attatagaac
    46441 ctacgattaa tccaattggc atacctaaac tttgaccaat tcctaaaaga gctactccta
    46501 ctgtacccat tgtgctccaa gatgaacctg tcgcaagaga tactattgca cagactaatg
    46561 ttgatgctac taaaaaaata tttggtgata aaatttttag tccccagtaa atcatacatg
    46621 gaactactcc acttactatc caagttccta taagtacgcc tattataatt atgattaaga
    46681 ttgcttgcat tgccatcttt atactattaa acatacttaa ttctaactct ttccatttaa
    46741 atccaagtct atatacagcc acaagtcctg ctactgctgc tgctcctatt agtggtacat
    46801 gaggtgatga accatacact aatactccta gacttaaaaa taatatcaaa caagtaattg
    46861 gtatcattgc atcaaacaga cttgcttttc tacattctcg ctctttcata aaatagtttc
    46921 ctcctaatta tttaaacact acactataat tttttttgaa acatatttgc tcgtactaga
    46981 tgacatgata cccccataag ttaataaaaa ttctaaattg tcacctaatt tataatcata
    47041 ttttgtgtta cttacatcta gtatcatgtg gtctgaactt gcccctaata tttttatatc
    47101 agtgtctatt ggaattaaag agtcaatatt tatatcttgt ttacctatag ctatgattgc
    47161 cctttttaag attcccttat cttcataaac aggtttattt ctaaaggcat caactcctat
    47221 ttctccaata ggaactgatg gtttttcttt acattcaact acttggcata ttaatttaaa
    47281 tgcatcttga tatgttccat ttatattttc accgtatgcc gtttctctac caagtagaat
    47341 ggactcgcct attctcaaat tagtaatacc ttctggcata ttattattta tcaacagatg
    47401 aatagaactt gaattacctc cagatactat ttctagattt attccaaatt tttcttccat
    47461 tctttttgct atacttacca gtctgcctat attttcccta gatggtataa tagctccata
    47521 acaggttaag tttgtagcta taccaattat ttcaatattt tttaatctta ctatctctct
    47581 tacattatta aaaaagtctt cttcataaaa gtatccttct cgtaaatcgc ctaagtcaaa
    47641 cataagaact atcttatgaa taatattttt actttcacat aattcattta atttctttat
    47701 tgttcctaat tctgagttaa aactaatatc gcaataattg ataacttctt ctaattcact
    47761 taacattggg attctaatca atatcttagg tagatttata tcttgtaaat tttttaagtt
    47821 ttgtattctt gaatctgcta tatggtctat tccttcacta catatttctt ctactatttc
    47881 tttttgtgca caaaatgatt tagtaacaaa agatatctta atatttcttt catgacacat
    47941 ctgcgaaatt aattttgcat tatgctttaa cttttctata tctatttcta acctaggata
    48001 cataatcttt cctcctcaaa attcaaactt tttaacagga gcttaagaga tgcttcttca
    48061 tattttttag ataaaacacc catagatgcc ataatatagt cattatctat taatatcttt
    48121 gttttttcct ttggaaatag taattcatta tttttattgt atttgagcat attatctaat
    48181 atttcaattc tactagggag cctagtaagt gctccccctg taccaactat atatcttact
    48241 tctgttaaat ctttcccttc tgcaattttg acttttccag ttgttccata gatatttctt
    48301 atttttcctg aatgtcttag catagcttta acaacagctt cttttgtcaa tctttcaaca
    48361 aataatattt cttcttttga ttttggtatt ggaggataat tctctattac tgcatcaata
    48421 tctatagata gttcactttg taagttttct ttacctataa cttctactat attcttcata
    48481 tttacatata cacctaaatc cccctcaaca cttctctttg cagtaggttc aggattaacc
    48541 aaaattttat taatatagtc acttccatct gtaacagaat gtacatcagt agttgctcca
    48601 cctacatcca gagttaataa atctccaata tttttatata aaagtttaga agcttccatt
    48661 acagctcctg gggttggagt aatattttca ttaaccattt ctttaatgta tttcattcct
    48721 ggtgctgtag ttatgtgttc ttcaaataca ctttgaatga ttcttcttgt aggttctata
    48781 ttcaataaat ctattttagg gtatacattt tcagttatat aaagcttata attagtatct
    48841 tcaaatatta accttatttc ctcttgattt tcaacattac cagcatatat aactggtatg
    48901 cctagattca tagaagctat catttctgca ttataaatag ctgtatctct ttctccataa
    48961 tcgactccac cagctattaa aattatgttt gggtttattt cttttatttt atttaaatca
    49021 gttcttttaa ttctacctga tgttatttga cgaataacag ctccagcccc taaagctgct
    49081 tctttagctg cttttactgt catatcatag actaatccat gaacagtcat ttttaatcca
    49141 ccagctgcac tagaagttgc aaacatatca ttatactcta tatcatctac agataattta
    49201 ttagctaaat ctttaatagc acctgataag ccatttctta catcgccacc ttcaaacact
    49261 gttgttggag cttgaccttg acccaaaaat ataggattgt tagtattaat atcgtggaaa
    49321 gcgtttacca ctgtagtagt acttccaatt tcagctacca acacatctat ttttaaagaa
    49381 accttgctat tttccattat ttattactca tttctcttct tttttcaact aagaaagtgg
    49441 ctacatgtat gcctttactg tttcttccaa atccagcatc tatgccttgt tcaacagcta
    49501 tttcaggtgt tacttgtgtt cctccacacg caatcattac tttatctctt ataccttttt
    49561 ctacacaata atcgtgtaat tttttcatgt ttttatagtg aatatcatca tgacttatta
    49621 ttgtagatgc aagtattgca tctgcattca gttcaatcgc tgcatctacc aatttttcta
    49681 caggtacaga agtccctaga tagtggcatt ctatgccata tttttcaata cctccatgtt
    49741 ttatatctat tatttctctt aaaccaactg aatgttcatc ttctccaacc gtagctgaaa
    49801 ctattttcat aggtttttct tctatatctg ctcttatttc ttcatcagtt agtaccttag
    49861 gttcttctgg tattactaaa ttgtttaaat ctatatcaaa cggaactctt cctttcactt
    49921 ctattctagt cccttcagat tcatgcataa cttctctact tatgacctca atttcttgta
    49981 agttcatttt tttgacaaat tccaaagctg caaactctgc tgttctttta tcagtaggaa
    50041 gcatcattgt tatcattata attccatctg cacaccattc catttcaggc ttaattttag
    50101 ttccatttct gtactcatat gattctttta gtctattttc tacattatca aaatcgtcaa
    50161 gctcatcaat atatattatt ttgtctggat tttcaaatgt acatccatct attaacattg
    50221 atggattatc tatagcattt tcatcatatt gagctacatt attgtatcca aagtgagcag
    50281 ttacaggtgc taaataatct tcttctcttt cataaacagt accttcacca actccacctt
    50341 ttatttttct agatattcca tcaccatttc tttctggata atttccagaa tcaacaaaaa
    50401 atccttgttc cacagattca aaatatccac caacttcaga tatttcttcc atatataata
    50461 cagctctttc tttaagttct cttgctttgt ctcttaattc accgacatct ttaagttcta
    50521 tcatatccat aagcccatcc ataccaacta aagcttgctt tgctgtatca catgcttcta
    50581 tattgtatat atgccaaggt acatttctac cttcatcagg tgttatagtt gattgtatgt
    50641 cagctctagt taatactgat gttaataagt ttaatacatg agtaactgtt gcttctctag
    50701 ttgatgattc catatattta gtattcattt gagctctcat cttataatca ctaaataact
    50761 ctctaagtgc aacagcgtaa ggtaagtcta tttttaaaca tggtgctgga ggtgctgttg
    50821 gtggaactgt tgataagcat atattacttt tatctatacc tattttttct gagaatatag
    50881 agtttaaagc gtgttgaacc ataagttcag gcattacctt ccatgcttct ctagcagtag
    50941 cattagcatt atgtgctcca tcaatttgag ctatattggc aaaagccatt attttctttg
    51001 cctcacaagc atctacaaaa gaccttacca tgtttatatt cctatacaga acattatatt
    51061 gtgggtcttg atgtgctcca ttaactcctt cctcagcaaa cattactgct acttcaggac
    51121 cagcaacacc acttacatat gaatgataat taataggtct accaacttct tcttctataa
    51181 aatcaagagc cttcctttga gctcttactt gttttcttgt tattggaact ccacctatac
    51241 cttgtggggt tccttctata agcccatcaa aatgtgattg tccagcagtt ctgataacca
    51301 ttagatggtc agctccatga tgagctgcca ttctcattct tcttatatca tcctcaaatc
    51361 taccagaagc tatttcagta gtaataactg gacttggttg agggtctata ttattgaaat
    51421 acttagatga tggtagccct acactcttct ttaaaggttt tgtacagtct ttatatttaa
    51481 aaggtcccat ttcaagattt tccaagtgtt ctctccaaac ccaacctctt cgttttggtt
    51541 tatatttatc caaatctttt aatatatagt ctatatccaa ttttttattt tcctttaaca
    51601 tgattctacc ccttctctaa ataaacatgt aacttcatcc caatattcac ccttaactaa
    51661 taacaaacct gcttctctaa ccgttatatt tttagattta gccaatttat aaactacatg
    51721 ccctgctcct ttacctataa gacctctttc cataacccct tctaaaatag gttttacttc
    51781 aagagaagaa aatcccattc tcaacaagac agacctttct attgatggtg ttgtattctt
    51841 tttaccaagt tctatcattg gttctactat ctgggtagct aaactccaaa acctttcttt
    51901 taactcatca tcactcagtt cttgaagatg ttttcttcta acttcaaaat catcctctct
    51961 ttttttcatg aacattcctc cattcgtatt gatttaatcg aattttctga atttttattt
    52021 tatattaaat taaaaaacaa taattactat aaattattta atacatcaac aacaaaatct
    52081 cttgaacttt ttacttcttc cattaaaaat tctatatctc gattacttag cttatcaata
    52141 ttatcaatgt gattattaga tatacaattt tttataaatg actttcttat tttattcata
    52201 tcaatatcaa cacatttcaa taattctggt ctttctggta atattaagtt tactcctgca
    52261 atttcttctc ttggatttcc aaattttata tctattccat tttctcttgc aaaggtaagt
    52321 tgtggacata tatgtttacc tgcacccgta tattctgttt cttgtaccac tatagcttta
    52381 tcctcatcta gctcttgagc taaagagaat gctgctgcta aagatgtatt tcctgctgga
    52441 cctctttcta taccttctag ctgtgccaat aattcagttg tataaaaaac ttctccttgt
    52501 tttactaata catatctatc catatatcta agtggtctag ctgcagacct aggtacatct
    52561 gacctatcag gccatgtaca gtatggtatc ccaaaacctg tatgtcctgt tgtaaatgat
    52621 tttttattaa attgattatc actagccatg tgtaatcctt ttaaatctac acttgctcct
    52681 actactttag tattaataga accagctttt atcaatcctc ttgcagttcc agtaagatta
    52741 ccaccacctg catttgtaca aacaactata tcagggtctt ttttatactt ttctctaaat
    52801 tggatagcta actcataacc taaagtttct acacctgcaa ttccaaatgg tgaatataat
    52861 gatgcgttaa aatagcctgt ttcttctaat aaaactaaga acgtataaaa taactctggt
    52921 ccaacagtta actgaacaac ttctgctcca tatgcctcac attttcgcgc tttttctatg
    52981 atttcaggtt gacctacacc attagaatca taacattctt gaactattat acattttaat
    53041 ccctgcattg ccgcttgtga tgctacagct gcaccatagt taccactggt agctgctatt
    53101 acacctttat atcccatttg tttggcatga tatactgcag tagctgctct tcttgcttta
    53161 aaactaccag atgcattcat tgcttcatct tttacaaata ttctagctcc tttaccttct
    53221 ttagcacatt ttctagctaa tttagtcaaa tttttaagct ctattaaagg agtatttcca
    53281 acagcatact gtgattgaat tgcttcaata tcttgtaatg tatatcctgt ttcactcatc
    53341 attttctcat aatcaaaccc tattccctct tgttcaaaag aagaataatc caatccgatt
    53401 gcatttttca ttatttcgtt atttcttccc ataacagctt gataactcat atctttcatt
    53461 gatgttgaat tattcattat atacacctcc aaataatatt tctttagctt ggattcctat
    53521 ttggagtaac tctggtatac atttaccata atcatgagta taatatggat ttattttaag
    53581 taaattacct tttacaagtc tgcctgtaat tgttttaact tctactaagt cgcctataga
    53641 agcatcactt tgtataaaac ctttaaccca catttctaag gatactttct tagtatcctc
    53701 tggaacttgt ggagctcttt cttctggagt caatactata ttgtgtataa taacccaatc
    53761 attaatttta gcatccattt tttcatcccc ttattaattg actattgcct tactaattaa
    53821 tttactgtta ttttaaatta aacattattt taccaattag ctaactgtta tcttactaat
    53881 tagctagttg ctatcttact aattagcctt tgattcttct tccaattcaa cttctatctg
    53941 atttcttata tctcccatta ttgctctagg tactggtata tccaacatag ttttaagacc
    54001 tggtctagca tttattatta atggaataga gtttactatc attgcataag tacctactcc
    54061 tccaggtatt tcaggattta tttgtaaatc aatgtttggt atacctttta ttgatacata
    54121 gtctcctgtt ttaatacctt ctgcttctgg tattatctgt tgtggatgct ccatttcaat
    54181 taaaacttct ccatttacat atccatatcc acattgtcta caaccagcaa catttccagc
    54241 caatgcctct ccgtacttag attttctatc tactgtagtc attattggct cttttgtttg
    54301 ttctatctta tctaatttcc aacctaatcc atcagctatc atatttattg attctacaaa
    54361 acctacatga cctgctatag tcttatcttc tacacctttt ataaattctt cccttgttac
    54421 tccaacacct tgttccacca taacagactt tccaaatgga gataaatcat ttactctctt
    54481 agcttttata ctagtaactt cttcacaagt acctgaaagt gccaatacta gtaaatctaa
    54541 tacaaatcct ggatttattc ctgttccaag tatacttact ccattttcct ttgcaacttc
    54601 atccattttt ttagctaaat ctgcatcatc agcttgtgga tatgccattt gttctgctgt
    54661 tgatataaca tttatttttc tatttaataa gaaatttatt ttatcaaaag cctttttagt
    54721 aaatgaatca gttgctaaca aaacaacatc tacacttttt tctctaaaaa cttcttcata
    54781 atttttattg ataataactt ctggtctttc tcctctttca attcctaaaa catcatacat
    54841 acttttccct gaagtacttc tactacaaac agatactatt tctatacctt ctttctttag
    54901 aatcatatta gccataccta ttcccatagc tccaaatccc catattccta ctcttacttt
    54961 tctcatatat acaccctcct aaaaatttat atattctcaa taattagtta aagcataaat
    55021 cgtgccaact ttaaaattaa agtaaatatt tattggaacg ttgaaactat aattatttta
    55081 ttatgtattt tcataaataa aaaataatat ttcttatgag aaataaaaaa aagagcaaaa
    55141 tattttgctc ttttataata attttgctcc tctattttgc ttttttattt tactttgatt
    55201 ttgttttttt atcttgctta tttataatat tttgatatta tattttttta ttttatactg
    55261 taaattttgc ctattcatac ctaaaattga tgcagcttta gttatattgt aagatgcctt
    55321 ttctaatgat tcatatatat acttttcttc tatctcactg ataatcttac taagtgtttt
    55381 gtcctccaaa tcgtttaaag aataattgtt actctcttta ttctctttaa gagtgtaata
    55441 gtcgtttaga ttaatcatac ttgtttctat ttgtacctca tcttccatca tactcatagt
    55501 acaataaatt atgttttcta gctctcttat gttaccttgc caatcgtaat tttttaaaat
    55561 tttaatagct tcatctgaaa ttcctaccac ttttttattt aactttttat tatactttga
    55621 aataaatttt ttgcacaata gaggtatgtc ctcttttcta tctctaagag gaggaatttt
    55681 tatatgaatt atgttaagcc tataatataa atcttttcgc attttatgct cgtttaaaat
    55741 tacctttgga ctttcatttg tcgttgcaat aattcttaca tctataggta tatccttagt
    55801 tcctccaacc cttcttacat aaccttcttg taaaaccctt aatagtttag cctgtaacat
    55861 aataggcatg gaatttatct catccaataa caatgtccct ttgttagctt gttcaaataa
    55921 gcctggccta tctattgctc ctgtaaatcc tcccttgcta gttccaaaaa gaataccttc
    55981 gaatagtgat tccggcaaag ctgcacaatt ttgtgctata aatggatagt ttctcctatt
    56041 acttccatag tgaatggact ggctaaataa ctctttaccc gttccagttt caccgtatat
    56101 aaatactgaa gcatcagact tgcaagcttt cttagattta gctattgctt ctttaatcaa
    56161 attactttcc cctaaaatat catcaaattc ataacccttt ttttgtctaa tactaacttt
    56221 attgactaaa ttttttttat aatttctatt tagtaaattt tctatcgttg tcatattctt
    56281 tgatatttca agtgccccta caaactcgcc tttaatatca attggtattg tagtattaat
    56341 tgctgttatc tcttttccat ttttatccag atatttttga atattgtctt tgataacttc
    56401 ccttttttcc aaaacttcta atagtgtact cctgtttatt ttcattttgt tgactatatc
    56461 aaaaaatgaa ttggttaaaa tatcgtgtct gttcattttt tccatttttt gtacagaatt
    56521 attgtagatt atagttttcc cgtctttatt aacaaaatgt accccttcat caatattttc
    56581 caatatttca ttcattattt taaaaaatat ctcttggttc aactatatca ccccagtacc
    56641 taaatatata aaaacccaaa aaattaataa aatgttgcta ttgtatttat cttatcatat
    56701 atttatgata ttttttatgt acattatatt aatatatttt taagtatatt taaaatttta
    56761 tttatatatc tttcattatg gttatataca atatttga
//
LOCUS       DAEPID010000017        55599 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.017, whole genome shotgun sequence.
ACCESSION   DAEPID010000017 DAEPID010000000
VERSION     DAEPID010000017.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 55599)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 55599)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..55599
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.017"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            complement(165..578)
                     /locus_tag="KR257_001174"
     CDS             complement(165..578)
                     /locus_tag="KR257_001174"
                     /EC_number="4.2.3.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438060.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="methylglyoxal synthase"
                     /protein_id="HBH0029893.1"
                     /translation="MNIALVAHDQMKNTMVGFCIGYESILKKYGLYATGTTGKRIMDE
                     TELNINRLASGPLGGDQQIGSLIVTQEIDLVIFLRDPLTSQAHETDIQALIRLCDVYH
                     VPIATNLASAEIFIKALDRGELSWREVRKSKSQRI"
     gene            complement(619..1749)
                     /gene="rodA"
                     /locus_tag="KR257_001175"
     CDS             complement(619..1749)
                     /gene="rodA"
                     /locus_tag="KR257_001175"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009905338.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="rod shape-determining protein RodA"
                     /protein_id="HBH0029894.1"
                     /translation="MKKININYKSTIKLIKQLDWKLIVTVLAIFIFGLVILSSATHAN
                     STGSYNQLIKQGLAFVLGIGMIIVILFFDYNLLGRYYKALYIISLILLAIVLLPGIGT
                     VKGGARSWINLGPLDLQTSEIVKLTFVLSYAKILESKKDKLNTLKEVMPVVVYSLPFI
                     GLLIAQPDLGTGIVFCCMIFAMLFTAGLSSKLIKRGIIILLVSMPLMYLMMADHQKVR
                     IEAFLNPEDVTLKGNYQVMQSLIAIGSGGVTGKGLYNGSQNQEDFLPVQDSDFIFAVV
                     GEELGVIGMAVLIILFMIFLLRLLAIARDAKDFYGTLIVVGVMGMFGYQIIQNIGMTV
                     ALIPVTGVTLPFVSYGGSSLLTSLANLGLVLNVCMRRKKINF"
     gene            complement(1834..2118)
                     /gene="minE"
                     /locus_tag="KR257_001176"
     CDS             complement(1834..2118)
                     /gene="minE"
                     /locus_tag="KR257_001176"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419058.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell division topological specificity factor
                     MinE"
                     /protein_id="HBH0029895.1"
                     /translation="MLDLFRVFSNEAKTSKSVAKERLKLVLVHDRVDCSPQLLEMIKT
                     DILKVIANYAEIEDDGLEIKMSKCRGEHDDKPVSALVANIPLKNIKDRCM"
     gene            complement(2136..2933)
                     /gene="minD"
                     /locus_tag="KR257_001177"
     CDS             complement(2136..2933)
                     /gene="minD"
                     /locus_tag="KR257_001177"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419057.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="septum site-determining protein MinD"
                     /protein_id="HBH0029896.1"
                     /translation="MSEVIVITSGKGGVGKTTTAANLGTALSLENKKTVVVDADIGLR
                     NLDVVMGLENRIVYDIVDVVEGTCRLKQALIKDKRFDNLYLLPAAQTRDKNAVSVEQM
                     IDLCEKLKESFEYIIIDCPAGIEQGFKNAVAGADRAIVVTNPEISAVRDADRIIGLLE
                     ANEIKEIRLVINRIRNDMVKRGDMMDKQDIIEILAIDLLGLVPDDESIIISTNKGEPA
                     ILDSKSLAGQAYKNIAKRILNEEVPLLDLEVEDGFFGRLKKMFSMAK"
     gene            complement(2957..3640)
                     /locus_tag="KR257_001178"
     CDS             complement(2957..3640)
                     /locus_tag="KR257_001178"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419056.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="septum site-determining protein MinC"
                     /protein_id="HBH0029897.1"
                     /translation="MSLREICSQELVEFKGNKRGIIVNIKREAPFEEIQEKIINKLEA
                     YVGFFNGAKISKINSDCLTDMEILELKEGITSRFDVEFVEDQKIEENSNFPTKYVNTL
                     RSGENIEFEGDVVILNDMKPGSKVLSKSNTVVMGDINAGAKVVAGGNVFVMGKIEGFV
                     HAGAEGNEFAYVVAGNLNPKILQIADNIAEAPDDEENYESESEISPEIAFVSNGRIVI
                     ESYLSKLDK"
     gene            complement(3738..6716)
                     /locus_tag="KR257_001179"
     CDS             complement(3738..6716)
                     /locus_tag="KR257_001179"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896080.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="penicillin-binding protein"
                     /protein_id="HBH0029898.1"
                     /translation="MEENKQVDRLKIIKIVMGVIFLAILVKIIYMTTFKYEYYNELAE
                     NKTYKKLAIEAPRGEIKDRYGRLLAGNKNLFTVQVSGNDINKKDANKHSRANEISLKL
                     INLLERNGEEYVDEFPIYVENGKYYYTYDRDIREYKSENGIPNDYNAKESFYYLVDKL
                     ISAGILSQEDKRLDATRLQAKLNENGYYPPILVSKWMFTAERDKRDWLASYKIKETKL
                     SAKEAFEKVRNSDALEIDKSLSDEDARKIMVVRDLIKSKGYSQYNPVTIAKDVGETTI
                     AQIEESAMDLVGVSIAVEPVRYYPNGSLASHMLGYVGKMPSTQIESYLQKGYETGDMV
                     GLAGVEKSNESRLRGTDGYKMVKVDALGRISKEIESKKPKSGDTVYLTLDKDLQEVSD
                     NALKQIIEVASKGGTFKSKFGDKPISAYAGKAQSAALIAIDVKNGEVLASSSYPNYDP
                     NKFAKGISTEDYKALQPKNPNDLLAGSPLLNLVTQGEFQPGSSFKMLTSMAALENGLD
                     PNFTINDPGVIMLGKKSFGDYVWNHGRGNHGMTNLYKAIQESCNIYMATIGTGKTWPD
                     GKSIGIDMNANKILEYAKLFGLDQNTGLQDEVEERAGKVPSTEDKLKSTQALLKSNLE
                     REMANDFVDITREKNPKEYEKRINEIVSWAAEKKTPGRVETMNRLKKLDVKEDRIEEV
                     ADLAVFSYFNFAKWSTADTFNLAIGQGENAYTPAQISRYVAAIANGGNLVELSVVDRA
                     VSSDYSSVKINDQKKVEKIPFKNPDNLKELTKGMKLVARQGTAKSAFADFPIDVAAKT
                     GTAEKSGKIPTDNEYEYLKSHMSSYNVNLNDAIKLADKMKAEKEKELSLAKEKEIKKK
                     LENKDLKDEERKKLEEELEDGVKVRLEDTDKVNSSYLRKAIKELNPKITDDQIDRFKQ
                     DYGSFTWTVAFAPADDPEIAVVCVIPQGDSSVFSLLPTREVIGTYMGLEPTNSKNDNK
                     TNDVNNSSDENINFESQINR"
     gene            complement(6728..7216)
                     /gene="mreD"
                     /locus_tag="KR257_001180"
     CDS             complement(6728..7216)
                     /gene="mreD"
                     /locus_tag="KR257_001180"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438053.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="rod shape-determining protein MreD"
                     /protein_id="HBH0029899.1"
                     /translation="MKKVLLCLLGIVLMTIENSITNYIDIFGISFNLVLIYVTIISLY
                     LDELEGGIIAAIIGLIKDITVGGIFGVNALILFIIAYAIGYMRDQLYKGSYIITFVLI
                     FIGSLIDSIVNIGTSSIIYQSYNISTLFVKGLLVAPIVNSLIGLVIYRLSKRAVLKLK
                     ED"
     gene            complement(7231..8124)
                     /gene="mreC"
                     /locus_tag="KR257_001181"
     CDS             complement(7231..8124)
                     /gene="mreC"
                     /locus_tag="KR257_001181"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428482.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="rod shape-determining protein MreC"
                     /protein_id="HBH0029900.1"
                     /translation="MALRFDKNKNEKKRINVKVIATGVVAITLIGIVGISIGKFSSGS
                     PVNLGVASDAITSVGKGINDGFSFIKNGFKDVANFKDNSKKVKKLEEENEKLKKNMIA
                     LNAKLDKTESLEELKKTLNFVQEEYKATSISASVVGKNDGNWYESFVIGAGKNSGVKK
                     ESIVMNGSGLVGIVYEVSNNYSKAISLLDSKASVSFKLAKDANAKGTITQNTTLDNKD
                     SYNSKGYLQGYMFDSSYNVIQGDIITTSGLGFFPDGIPIGEVEKVVDDKDKSLKYVVV
                     KPYVDFKNINDVVVIEPRNIG"
     gene            complement(8134..9144)
                     /locus_tag="KR257_001182"
     CDS             complement(8134..9144)
                     /locus_tag="KR257_001182"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009905332.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="rod shape-determining protein"
                     /protein_id="HBH0029901.1"
                     /translation="MTKDMGIDLGTANTLVYIKGQGIVVREPSVVAIRDDSKEVLAVG
                     EEAKKMIGRTPGNIVAIRPMKDGVIADFDITQSMISYFIQKAADKKGVVSPRIAICVP
                     FGVTEVEKRAIEEAARQAGAKDAFLIEEPMAAAIGAGLKVEEPEGNMVVDIGGGTSEI
                     AVISLGGIVTAKSIRIGGDEFDESIVAYVKKEYNLMIGERTAENVKINIGSTFKDDEE
                     INMQIRGRDLISGLPKTIEICSTEVREALKEPVSSIVDAIKSTLERTPPELASDIMEN
                     GIMLTGGGALLRGLDKLITQETGMSVQIAETPLDCVALGTGKSVEDQEIFEKVLMMNT
                     KN"
     gene            complement(9265..9924)
                     /gene="radC"
                     /locus_tag="KR257_001183"
     CDS             complement(9265..9924)
                     /gene="radC"
                     /locus_tag="KR257_001183"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009905331.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA repair protein RadC"
                     /protein_id="HBH0029902.1"
                     /translation="MAPEERPREKMLAKGVKSLSNAELLAILLRTGNKNKNAIELANY
                     IINRDIQGIRHLEDMTIEELCNIDGIGLSKSTQIKAALELGSRVASFKPIKYKIRNPW
                     DIQRYYMDSLRYLKKEVFKAVLLNTKNEIISDVDVSIGTLSSSLVHPREVFKEAIRRS
                     ASKIIVMHNHPSGSVEPSREDKNITSRLIKCGEIIGIEIIDHIIIGDGLYFSFKENMI
                     I"
     gene            complement(9969..10553)
                     /gene="maf"
                     /locus_tag="KR257_001184"
     CDS             complement(9969..10553)
                     /gene="maf"
                     /locus_tag="KR257_001184"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428485.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="septum formation inhibitor Maf"
                     /protein_id="HBH0029903.1"
                     /translation="MNIILASASPRRKEILENTNVRFDIIKNEIDEIILEGETPKHLV
                     MRLAFEKSMSVASEHNEDVVIGADTVVVLDNAILGKPKDESCARDMLKRLSGREHQVI
                     TGISLINLCEDKKVIDYVISNVKFKTLSEQDIEDYLKTNESFDKAGAYGIQGYGALLV
                     EEIRGDYFNIVGLPISRLGDLLKKYFSINLFYGV"
     gene            complement(10773..11744)
                     /locus_tag="KR257_001185"
     CDS             complement(10773..11744)
                     /locus_tag="KR257_001185"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419048.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RnfABCDGE type electron transport complex
                     subunit B"
                     /protein_id="HBH0029904.1"
                     /translation="MVILTAVLVLGIMGLIFGIVLDFASKKFAVEVDERVEAILGVLP
                     GANCGGCGFPGCGGLANAIVEGNAPVNGCPVGGADVGAKVGEIMGISAEAGEKQVAKV
                     ICKGTCSSAKDKYEYEGISDCRAANVLNSGAKMCKFGCLGLGTCKDACKFDAISIVDG
                     IAVIDEEKCVNCGKCKEVCPKGIIITKPESQEVVVECNSKEFGKAVKEKCTAGCIGCG
                     MCVKACKFDAIIFEDKIAKIDPNKCVGCMQCVAKCPTKVISGDITKKKKVTIDQELCV
                     GCTVCKKQCKFDAIEGELKEKHKVDADKCVGCHLCMEKCPKKAIKIL"
     gene            complement(11760..12335)
                     /gene="rsxA"
                     /locus_tag="KR257_001186"
     CDS             complement(11760..12335)
                     /gene="rsxA"
                     /locus_tag="KR257_001186"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419046.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="electron transport complex subunit RsxA"
                     /protein_id="HBH0029905.1"
                     /translation="MNLILLFLSIVLVNNVITSQFLGICPFLGVSKKVDTAVGMGVAV
                     TFVLTLASIITYFIQILLVKTGTGFLQTIAFILVIASIVQFVEMVIQKMSPSLYQALG
                     VYLPLITTNCAVLGIALVNVQKSYNLVETIINGFGAGAGFTLAIVIFAGIRERLELAD
                     IPEAFKGFPITLISAGLMSIAFLGFTGLIKL"
     gene            complement(12350..12943)
                     /locus_tag="KR257_001187"
     CDS             complement(12350..12943)
                     /locus_tag="KR257_001187"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419045.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="electron transport complex subunit E"
                     /protein_id="HBH0029906.1"
                     /translation="MNLAKVFKNGLIDENPTFVQVIGMCPTLAVTTSAINGIGMGLST
                     AAVLICANLVISLIRKITPDKIRIPIFIVVIATFVTIVGMLLKAYVPALDKALGIYIP
                     LIVVNCLILARAESFAFKTGAMPSIVDGVGQGLGFTVALTIIGAVRELLGNGSLFGMT
                     LFGASFQPVLIFILPPGAFLTLGFLFAGFNKLRSKKA"
     gene            complement(12956..13525)
                     /locus_tag="KR257_001188"
     CDS             complement(12956..13525)
                     /locus_tag="KR257_001188"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902280.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RnfABCDGE type electron transport complex
                     subunit G"
                     /protein_id="HBH0029907.1"
                     /translation="MNSMVRLGGTLLAISAIAALALGATNQVTAPVIEQRNIQANNEL
                     RKAVLPEAKEFKEMKEDTYKGLGDGLIAEVYEGLDGSEVVGYTLKAKPSGYGGEIEVM
                     VGISSEGQVTGVDIGNMSETAGLGAKAKDDAFKGQYKGKTAEPLEVAKGSTTADNQIL
                     AISGATITSTAVTTGVNAAIDVFNSALNK"
     gene            complement(13525..14502)
                     /locus_tag="KR257_001189"
     CDS             complement(13525..14502)
                     /locus_tag="KR257_001189"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419041.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RnfABCDGE type electron transport complex
                     subunit D"
                     /protein_id="HBH0029908.1"
                     /translation="MENKLIVSSSPHVRSNEDTSYIMKQVIIALLPAAVAGVYFFRLN
                     ALSAMFFCILGTVGTEFLYQKFTKQKSTIGDFSAVVTGLLLAFNVPASLPWWMCLVGG
                     IFAILVVKMVFGGIGCNFVNPALAARAFLLASFPVAMTAWTQPGVNWIGKNLDAVTTA
                     TPLSFLKNGAAGLADISSNGISLADMMIGNIGGCIGETSAILLLLGGVYLMYKGIINY
                     VIPVFYIATVFILTFLLGGFNITFAIYQLFAGGLMLGGFFMLTDYTTSPMTKKGQIIY
                     AVLAGLITTVIRMYGGYPEGVSYSILLVNCLAPLIDKFVRNRVFGEVAK"
     gene            complement(14525..15862)
                     /gene="rsxC"
                     /locus_tag="KR257_001190"
     CDS             complement(14525..15862)
                     /gene="rsxC"
                     /locus_tag="KR257_001190"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419040.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="electron transport complex subunit RsxC"
                     /protein_id="HBH0029909.1"
                     /translation="MKLLTFKGGIHPPYRKEYSNTKALEKAQAPKIVYIPLQQHIGAP
                     AKPIVEVGDEVKFGQKIGEQQGFVSCNVHSSVSGKVIAIEQHEVPGGSAQCVVIENDF
                     KEELHESVQPKGQLEDLSKEDIVGIIKEAGIVGMGGATFPNHVKVSPPPDSKAEVVIL
                     NGAECEPYLTADHRLMVENPEDVVFGLRALMKVLDVKKGFIGIETNKPDAIEAIQNVA
                     KDYSEIEVVGLQVKYPQGAEKQLIYACTGKEVPSGGLPIAAGAVVDNVATAAQIAKSI
                     KTGMPLVERITTITGSCIKEPKNLITKVGTLVSEIIEQCGGFKEDKKIGKVIMGGPMM
                     GIAQYTTEIATNKGSSGILCLDEEESRTPDIQNCLRCGRCTDVCPSFLQPLFISAYSL
                     KDDYDTAEYHRAMDCIECGSCSFICPARRPLLQSIRSAKREIGAKRRKQAAQK"
     gene            complement(16078..17022)
                     /locus_tag="KR257_001191"
     CDS             complement(16078..17022)
                     /locus_tag="KR257_001191"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428490.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0029910.1"
                     /translation="MNRRKTIYRGFNNNRHKIDLRKYVITIACLCLIGYYSYTKIKDS
                     KILEYVSAKIPFLNNSSDITYKDISDELNSIKKGKKSKSQTNSDDKQETNPEKAVNNT
                     KEPEEVKLATIEGWDMYTIQVAAIDNNDDLKKIQTSLVNNDIPFSVMEKDGVKKIQTY
                     SSFDENDVRKQISSVRKVFPDAFLSHLDAPMLSLEYTSNYAYIESISKELNKLITNFK
                     EESSFWSNAENNVDMEKYNTILTNRKAISQNISKEAEKIDYSEMRLFKDNLIEYVKNV
                     NEKIDTASKAANEEKYSVSKSLLLSSMQEYSMFINSIK"
     gene            complement(17133..18407)
                     /locus_tag="KR257_001192"
     CDS             complement(17133..18407)
                     /locus_tag="KR257_001192"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729513.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SH3 domain-containing protein"
                     /protein_id="HBH0029911.1"
                     /translation="MKKAIAALGIGAVAVSVSSINASALEKGTVTASALNIRSGPSSD
                     CDKVAKLYKGKTVEILEKSNGWYKVRVSSSVVGWGSAKYISTSGSSEGTSSQNNPTSS
                     GTTISGNGKVNVSSRLNVRSGAGTNYSLVGKANNGDVVKLLEQSNGWYKIKLSNGVTG
                     WASSQYISKTSEDVGTNNSSNSNSTNNSDKKPSSEESIEGKNGKVTSAVSLNVRSGPG
                     TSYSIIGKLNGGDVVELKAKSNGWYKVKLSSGTIGWVSASYISETNEDTKEKPNSSSN
                     QNSQSNSNSKPSFTGNSDKSTAKGSTIVDFAYTLIGIPYQWGASGPDKFDCSGFTQYV
                     FKHSVGVSIPRVSREQANFGSAISMGNYAPGDLVYFDTDGDGTTNHVGIYVGNSKFIH
                     CSGTQTNPNKVKVDNLTSSYWSKVLLGARRFV"
     gene            complement(18539..18910)
                     /locus_tag="KR257_001193"
     CDS             complement(18539..18910)
                     /locus_tag="KR257_001193"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419037.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="VOC family protein"
                     /protein_id="HBH0029912.1"
                     /translation="MKFNFCHNNFNVTNLEKSLDFYKKALGLKEVKRKEAEDGSFILV
                     YLGDGITSHTLELTWLRDWDRPYNLGDNEFHLALEVEEFDEAKKLHKDLDCICFENES
                     MGIYFIADPDNYWIEILPKNH"
     gene            complement(19138..19737)
                     /locus_tag="KR257_001194"
     CDS             complement(19138..19737)
                     /locus_tag="KR257_001194"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419035.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0029913.1"
                     /translation="MESRGYKEDLKKMILDMAHKELESYVSQKGAKKYFEGNLDKIIN
                     NNIKKFNQSIGLNRVYLKMLKKCAYQESVTSISRTIKKEALFKSKKELFAFSEYLKLD
                     INKRLSYNQILRKISRYIYYNRSSYAQKYVVFKRGDEEYLLEPEKIKDELISSYRSKT
                     REDMRSIAKLLDIEVEDDYNAEDIRKKVINYIIKEKLKS"
     gene            complement(19938..20150)
                     /locus_tag="KR257_001195"
     CDS             complement(19938..20150)
                     /locus_tag="KR257_001195"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419026.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="heavy-metal-associated domain-containing
                     protein"
                     /protein_id="HBH0029914.1"
                     /translation="MKKKLLVEGMSCGHCVNHLKTALTEDIDGIEVLDVDLENKCASV
                     DMKDDVSIEKLKEVIAELGFELKGIE"
     gene            complement(20223..21938)
                     /locus_tag="KR257_001196"
     CDS             complement(20223..21938)
                     /locus_tag="KR257_001196"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888909.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="HBH0029915.1"
                     /translation="MKRIKVLTVVLAITLMVAGCSNTKTKQSSSDSSLQSQSSIDAKY
                     INLTMVTPKTINPITNTDKSVGYIMNLVYDSLFTIDENYNVIPQLVKEYNIAQDGMSI
                     DIKLKDAKWHDGKNITSNDVNYTIGLIQKSADSPYNEFTKNIASVNIKSDKDFTIKFK
                     ARYAFSIDSLIFPIVSQNHLDSKDVNDKNNNMIGNGKYKIESYTEREGMVLSVNKDYY
                     EEVPKTMKNIKVGMVPNEDARTSMVMALDSDITNVTLNDLSKFQEKEFNITKYQGRDY
                     ECVLFNYNNPFFKDVNFRKAIAHSIDKDRIISEGYMDDATPVNFPLNSKSKYYNSEMK
                     DLEFNKDKAIECLAKVEYANVNSVNQNDNKVKNQKKSAKKNSKKLTPEEEAKAKKAEE
                     DRIKKEAEEKKNREKEEVKKSLSEMNLKIIVNRDNSERIKTANIINENLKAIGINSTV
                     NQLSDKDMENALNSKNYDLALVGWKLSIIPDASSIIASSGYTDDKLNGYMSALTSSTS
                     EIETKKAYKDVQTYIKDNATFISLAVRNNYIVSNSRLKGKITPNDFDVYEGISNLDIK
                     SNESN"
     gene            complement(21938..22492)
                     /locus_tag="KR257_001197"
     CDS             complement(21938..22492)
                     /locus_tag="KR257_001197"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438043.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="lytic transglycosylase domain-containing
                     protein"
                     /protein_id="HBH0029916.1"
                     /translation="MNSKKVLILSIFIILFGALLMESKVIHKFLYPKKYSEYVEKYSK
                     EFNLDENIVYSVIKAESKFNSSAVSKKEAKGLMQILDITRDWGAEELNLKNVDIFDPE
                     TNIRLGCWYLSKLYKEFGKLDLVIAAYNGGSGNVKKWLENNEYSKDGENLHDIPFKQT
                     SKYVEKVKNNYEHYNKIYGKKGKN"
     gene            complement(22485..23087)
                     /locus_tag="KR257_001198"
     CDS             complement(22485..23087)
                     /locus_tag="KR257_001198"
                     /EC_number="2.7.1.24"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419019.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dephospho-CoA kinase"
                     /protein_id="HBH0029917.1"
                     /translation="MLILGLTGGIGCGKSSLSNIFRNLNIPIVDADIISRKIFEDKLL
                     LEKVFVHFGQSIKNDDGTLNRKALGKIVFSDEEKLKELNNLTHPRIREKIISEIEKLR
                     KKGENIVVLDAAILVESGFLDMVDKLLVVTCKQEVQISRIQKRDNCSEQEALSRINSQ
                     MSQEEKSKYGDYIIDNSGTITELESKAHKFIEYMKENWRE"
     gene            complement(23096..25744)
                     /gene="polA"
                     /locus_tag="KR257_001199"
     CDS             complement(23096..25744)
                     /gene="polA"
                     /locus_tag="KR257_001199"
                     /EC_number="2.7.7.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438039.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA polymerase I"
                     /protein_id="HBH0029918.1"
                     /translation="MEKKLIIIDGNSIINRAFYALPEMNNKEGLKTNAIYGFTTMLFK
                     MIDIYKPTHISVAFDRKAPTFRHLEYKDYKAGRKGMPDELAEQLQPLKDLLDKFRINR
                     LEIDGYEADDIIGTVSKKAEENGYKVYIVTGDKDAIQLASDNTTTLITKKGVGEVEEY
                     NFNSVIEKYEMTPTQFIDLKGLMGDKSDNIPGVPGIGEKTGIKLIKEFSSIENLIENT
                     DKLKGSVKKKIEENKEIAIQSKRLATIIRDVPIEVDLDSMIFGDYDKDELLDKFRYFG
                     FTSLLSRLVDLVDSDDTEHVEEKIEILKLKDIEKFIDEVNKKGQVILKTVRGQGNILE
                     KNIIYIFISVDGEKIYYVDSNEVSKLDSIFSNNEIKKYGYNLKDDYISLKPYNINLEN
                     MYFDITIAEYLIDSTSSTSYDCSAIAMKYLSKKVKSKEELLGKGVKSKNYEDLEFEDL
                     AEYMGQIICTVKETVPMMERSLMDMSMDGLFYHVEMPLVEVLGHMEYEGIKVDKSILD
                     ELSVEFKEIIATLEKEIYELSGEPFNINSPKQLGVILFEKLELPIIKKTKTGYSTNAD
                     VLEKLRDKHPIIDKITEYRQIVKLNSTYVEGLLNIINPESNRIHSSFNQTITTTGRIS
                     STEPNLQNIPIKMEMGRKIRKVFIADDNCKLVDADYSQVELRVLAHMSQDENMIEAFK
                     HHEDIHTKTASQVFNVPMEDVTSELRGAAKAVNFGIIYGKSDFGLADDLNIPVPKAKE
                     YIESYFAKYHKIKEFMDTTVEKASEDGYAVTILNRRRYIPEIKSSNFMERNRGKRFAM
                     NAPIQGSAADIIKIAMINVHKKLEENNLKSKLILQVHDELIVEAIDDEIDIVKKIVKE
                     EMENAVNMDVHLDVDLNVGSSWYETK"
     gene            25896..25983
                     /locus_tag="KR257_001200"
     tRNA            25896..25983
                     /locus_tag="KR257_001200"
                     /product="tRNA-Leu"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:25930..25932,aa:Leu,seq:caa)
     gene            complement(26170..26613)
                     /locus_tag="KR257_001201"
     CDS             complement(26170..26613)
                     /locus_tag="KR257_001201"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861121.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0029919.1"
                     /translation="MKKNMLYVGIIYFICGILLVLLATFTEFSFEAFIWGLSGAALGP
                     GVCMILQYMYWSKPERAVDYEEKIKNQRIEMNDERRIMLRDKAGRITNQIMCYVLVIL
                     IFIVSILSVFSVMVISKWVLVVLGLLILFQFICSVVVYNKLDKRL"
     gene            complement(26616..26813)
                     /locus_tag="KR257_001202"
     CDS             complement(26616..26813)
                     /locus_tag="KR257_001202"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004631111.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HBH0029920.1"
                     /translation="MKNRLEEIRKERGIKQEELASILQVSRQTIGSLENGRYNPSIIL
                     AFKIARYFDMSIEEIFIYEEE"
     gene            complement(27005..27871)
                     /locus_tag="KR257_001203"
     CDS             complement(27005..27871)
                     /locus_tag="KR257_001203"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729511.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AraC family transcriptional regulator"
                     /protein_id="HBH0029921.1"
                     /translation="MEWINKLNQAITYIEENLESGVDYAEAAKIACCSTFHFQRMFSY
                     IAEVPLSEYIRRRRMTKAAFELQNSNIKILELSEKYGYDSPTSFNRAFQNIHNISPSA
                     ARAKGVVLKAYPKMTLSIYVKGNIEMQYRIVEKKGFRIVGIKESMNMIVEECFEKVPK
                     LWAKCIKNGTIDKLSELINNEPCGLLGVSVCTNSKGLDYYIAAPTDKPVLEDTHEYLI
                     PSGTWAVFECVSPMPNALAIQELQKRIITEWLPSSGYVYANLPDIELYPNGDINAPDY
                     TTEVWIPIQKPS"
     gene            complement(28097..28966)
                     /locus_tag="KR257_001204"
     CDS             complement(28097..28966)
                     /locus_tag="KR257_001204"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438030.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nitroreductase family protein"
                     /protein_id="HBH0029922.1"
                     /translation="MDYKTIILNRKSVREYKNTDIKEEYLSEIKKYSESCKKLVPEID
                     VDVRIMNRSEVFNNLDKVAGYKGNMIDSPSYIIILSDIKDNYIENSGYIGESIIFKVT
                     ELGIGSCWVTFEDGKKVKEKLGINSDKEVTGIIAIGYGENVSNAKVLNATKTGQNYSK
                     SDMQVVTDKGSTRLGVEDVVYMNEWGNVASIEILEERALLDAFHYARLAPSTLNRQPW
                     RFIVDGGTVVLAVRKDGHTNLYEEKIDIGIVMLYFATIISATMFDLKWNLGTPDKDYK
                     VPEDYKIVGYCNI"
     gene            complement(29472..29693)
                     /locus_tag="KR257_001205"
     CDS             complement(29472..29693)
                     /locus_tag="KR257_001205"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418999.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0029923.1"
                     /translation="MNVNNHKCPECGEHSKKFEIVEENEDCVIFECYTCGTISILKYC
                     ENCKEFVFVNIPNNVETYEYCCGKCNNKI"
     gene            complement(30195..31175)
                     /locus_tag="KR257_001206"
     CDS             complement(30195..31175)
                     /locus_tag="KR257_001206"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418996.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0029924.1"
                     /translation="MGDTSRFYESVKNKYPKLKDGTRVHLWPKENIIIGPIYDEEDGY
                     KKSIGNVDSLSWKQIVILAECDGKNTTDDIINILSNRYRNIHNMKEKVMEFFMFYENV
                     YLTFEDDIQTLSSVFEITGNKSYITPLYFTIEIDGDNNTNDYFSEITSLLNCMYEKGC
                     RFIEVIGEDILKNKSMREIFQYMLDHFDLIVVTKDSFTIDRSLIKELDNYRHKVIWKV
                     YSKNDDTRIKLKEDIKITSLIKRGHTVVRGDREKAIKIEDMRFKDTKERFSKYGAEWS
                     HLYISSDGSVKSYSFQKDKRIYLGNIFNNSVEEIFLEMQNKIDKLEIVYQ"
     gene            complement(31339..32211)
                     /locus_tag="KR257_001207"
     CDS             complement(31339..32211)
                     /locus_tag="KR257_001207"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438026.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="metallophosphoesterase"
                     /protein_id="HBH0029925.1"
                     /translation="MIIKVSMTVLVLILLYILYKYETQHIETTEYTIFNKKIPKEFDN
                     FKIVQVSDLHNKVFDKNNKVLIDKIESLNPDVIFITGDLVDGENKNFQVALDLIDNLV
                     EKYEVYHIIGNHEQKSLIKKYKHLYKDYFKELYSKKIINMENESVRIYRGNSHLNLYG
                     LIIPLECYPYLFANNKKLELSDNFVEDNLGKVNENEYNILLAHTPFFFEKYAKWGADL
                     VLAGHVHGGIIRIPFVGGVLSPNREFFPKYDWGKYEKDNSTMILNKGLGGSKVLIRLN
                     CKPEIVKITFKYEK"
     gene            complement(32375..32926)
                     /locus_tag="KR257_001208"
     CDS             complement(32375..32926)
                     /locus_tag="KR257_001208"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888896.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="HBH0029926.1"
                     /translation="MDNKFPNVGENLRLLRQEMGISLDKASKMTGVSKAMLGQIERGE
                     SSPTVSTLWKISSGFKINFTTLLNENTNTYEVIKKEEVEPIVEQKGNMKLYPIYPFSP
                     QRRFELFIIELEENCTHVSSTHSHVLEEYVLVIEGKLDLNVDGKTYILESGHSIRFDG
                     TLEHIYKNLNKGKTIFHNIEVYR"
     gene            complement(32946..33848)
                     /locus_tag="KR257_001209"
     CDS             complement(32946..33848)
                     /locus_tag="KR257_001209"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888895.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycyl-radical enzyme activating protein"
                     /protein_id="HBH0029927.1"
                     /translation="MSKKGRVVKVQHFSVNDGDGIRTTIFLEGCKLKCKWCSNPDSWS
                     NIVKLGVMKDKCVSCNRCIDVCPQNISSLFDRAQINNKCDLCGECIKVCLKDAICIMT
                     EEMSVEEIVEEVEKDFIFFFESNGGITFSGGEPTLQIDFLRELVDIFYDKGINIAIET
                     CGYFDWNKVNDVFEKIDHIFVDIKSMDDNIHKEYTGVSNKIILDNICRLSKLNKSMVI
                     RVPIIYGVNDSEENIRNTALFVKQNVPGGKMELLPYHKFGIDKYKALGLEDYIYEFDD
                     ICNNHMLKLKEIVELTGVKIIEYK"
     gene            complement(33863..36235)
                     /locus_tag="KR257_001210"
     CDS             complement(33863..36235)
                     /locus_tag="KR257_001210"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888894.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="formate C-acetyltransferase/glycerol dehydratase
                     family glycyl radical enzyme"
                     /protein_id="HBH0029928.1"
                     /translation="MSQTNRIEAFRQEYINSKPMICCERARIFTESHKKTEGEAICIR
                     RAKAFLETCKELPIKIFENELIVGTAGKFRRTGILTPEFSWQWVDKEMDTFDKRTQDP
                     YVISKEQIEFIRKEIFPYWKGKSLEEVFLARIPEDTAKILVDTGIIDNDSKWRQAVGE
                     VTPDYQDILFVKGYKGIKEDADKKIKELDISVSENIEKIDFYKSVSIVAQGIMTLAQR
                     YSNLAKEMSKQETDEKRKLELIKISEICMNVPANPPTNFYEAIQFVWFVQLGGILSEN
                     PLALNLGRFDQYMYPYYENDAREGKITESEAQELIEALWIKLSEWVWTISANTANYFA
                     GYNQFQNLTVGGKKRNGTDGTNDISYMCLKATESVKTHQPGLSVRVSQGAPDNFVMAV
                     AKLVKQGTGFPAIHSDSAGAQMLLQDGYDAEDARDWSNCGCVVPHFRKTGQWTSAVNI
                     NFAAALEYAMNEGKSRLTGEKMGLDTKNITEFTSFEELKDEFLKQLAYLVKSSVIGTT
                     VAQQIHKEMVPRPFLSTCVDGCLDKGVDLSKGGAKYNIGPVLTGIGLGVVSNSLAAIK
                     KLVFEDKVTTLEELTKALNNDWEGYEELRKLALDVPKYGNDNDYVDSLAIEVSDFYYT
                     ETRKYKDIFGSKFNSAFMGISNYVPTGKIVGATPCGRKATKPLTEGVSPFVGTDTTSP
                     LAAMKSASKINHDVHTGGTLLNLRLNQDLVETERGLRNLTSMIKSYFALGGFHVQFNT
                     ISNDTLLKAQENPEEYKDLLVRVAGYSTQFVNLSREMQDAIIARNSHSNF"
     gene            complement(36456..37145)
                     /locus_tag="KR257_001211"
     CDS             complement(36456..37145)
                     /locus_tag="KR257_001211"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861120.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0029929.1"
                     /translation="MKVKRNINRVAIIVALNLSLALMVGCMSPVYDKNLSSSEQISKD
                     SLKEQVEDKKDESIELFNNYSQKINDAKGREEVKKDLSQRFSKAIIDSGYSITDSKSD
                     GSFVVSINGAEKPPEKNIRSLFYSMSEDDKEGKVTIDILCAKEYPEDDKLSESDKYIK
                     FIYNLFKSLTNTNLTEKEIFSMVEEDFNKGVGVVELPYMKDIHVEVNKVKQSTKVLKL
                     SLVYKFDISNH"
     gene            complement(37386..38765)
                     /locus_tag="KR257_001212"
     CDS             complement(37386..38765)
                     /locus_tag="KR257_001212"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428529.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sensor histidine kinase"
                     /protein_id="HBH0029930.1"
                     /translation="MLNFMTELLVVLSIFIQFSIMNGILIYKKDSKKNEKIVFYIVLF
                     LIYIIIQISRLFNGGNYFSNINYLFYILAFIAWGGYYNYFYKMGYIKYSIFFYLFSVY
                     YKCLDAVIYRILFFAITGNVISSKESLLVPHLESIKIQIYSNLIIILIYLIFSFFRKS
                     IKLISQDKRNYVYLLFALLVNTMNMLVNYVLKKLERFGSLHSEGYYFDNFVNPKLVGA
                     SSIFLILLFKEIIKENRLKSQAELIKNKLDMQYAHYLSIQESHMRVKKLYHDINNHIY
                     CIDNLRNNSKEINEYVNNLKDEIKTFKYIYNTGNMILDIIINEKSEICLKKGIKFTCS
                     INFSKVNFVKPIDVSSIFSNILDNAIEACDKIVDENVNKYIRIKGTMTRSFFVLKCEN
                     SKLNQLTFNKNILLTNKMDKFVHGIGIQSIKSSLQKYNGELLFENSIDKFILNIYIPL
                     DQDTDSWGD"
     gene            complement(38759..39472)
                     /gene="rgbR"
                     /locus_tag="KR257_001213"
     CDS             complement(38759..39472)
                     /gene="rgbR"
                     /locus_tag="KR257_001213"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438019.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="two-component system response regulator RgbR"
                     /protein_id="HBH0029931.1"
                     /translation="MIKIAVCEDEKETQLLIEDYLENILKDISIEYEIQKYISGEELL
                     ESNLKDIDILLLDIKMEKLNGMDTARKIREVDNEMEIIFVTSLIDYVQEGYEVRAYRY
                     LLKPIELEELKKHVLTCIKDIEINKESHITIKNKSNTYKIYLNEIKYIEVQKKDMLIH
                     TINKNFDIKYSLGKIEKELNPYKFIRCHKSFIVNLRYVENIKPNTAILESGEEVPISR
                     YRYKEVKEKFLKFLGDTIC"
     gene            complement(39722..40282)
                     /locus_tag="KR257_001214"
     CDS             complement(39722..40282)
                     /locus_tag="KR257_001214"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012816089.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF2812 domain-containing protein"
                     /protein_id="HBH0029932.1"
                     /translation="MSAMEKKIKFKFDWYSSPDKIEKWLEDIEAKGYNLYKINKFGGI
                     FYFHKGSPRKIKYTVDYYYDVENNYFDEHKSNGWNLVFRSIGSFMGTSAWYIWSKEYK
                     DIPPKLYSDSDKKNKVKSILFMNMFIFFMLVVIFIYLLNIEIRNLYSGYGASVTAIVL
                     QIILLILYAVQLYRRLMYYLRLKKFK"
     gene            complement(40378..41181)
                     /gene="zupT"
                     /locus_tag="KR257_001215"
     CDS             complement(40378..41181)
                     /gene="zupT"
                     /locus_tag="KR257_001215"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861091.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="zinc transporter ZupT"
                     /protein_id="HBH0029933.1"
                     /translation="MNNVIFAFLITLLAGLSTGIGSCIAFFAKKTNTKFLSISLGFSA
                     GVMIYVSMIEIFPKAQDALTKSMGEKLGSWSTVIAFFIGMAIIAVIDKLIPQEENPHE
                     IKKMENIEEKNIKKNKSLLRTGIFTAMAIAIHNFPEGLATFISALDDVTIAIPIAIAI
                     AIHNIPEGISVSVPVYYATGDKKKAFYYSFLSGMSEPLGAIIGYVLLRNFLNDITLGI
                     VFAIVGGIMVFISLDELLPSAREYGEHHLSIYGLIAGMGVMAISLLLFK"
     gene            complement(41332..42495)
                     /locus_tag="KR257_001216"
     CDS             complement(41332..42495)
                     /locus_tag="KR257_001216"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902264.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amidohydrolase"
                     /protein_id="HBH0029934.1"
                     /translation="MDIKEITKSYKDYVIKLRREFHENPEKSMEEVRTSKRVKEELDK
                     IGIPYVSAGGTGVIATIKGANPGKTVALRGDMDALQVVECTDVEYKSKNEGLMHACGH
                     DGHTSMLLGAAKVLNDIKDSINGTVKLFFQPGEEVGKGARAMIQDGAMEGVDSVFGIH
                     LWTDVESGTISVEEGPRMASADFFKITVKGRGGHGSLPHQGVDAVLASSAIVMNLQSM
                     VSREVSPLEPLVVSVGVLNSGTRFNVIASEAVLEGTIRLFNPELRKQIPGILERIAKS
                     TAEAYRADAELEYGYLTPAVINDKECSKIATDAAIKLFGEDCITLFEKVTGAEDLAEF
                     MNIAPGALAFVGARNESKGACYPHHHGCFNIDEDALEIGTALYVQYAVDFLNK"
     gene            complement(42555..43742)
                     /locus_tag="KR257_001217"
     CDS             complement(42555..43742)
                     /locus_tag="KR257_001217"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888888.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0029935.1"
                     /translation="MEAITAFCLVLVSLTIGDIVSAKTKAFVPSVFVSAIIFIVGFWT
                     FFPENIVDLAALGTPLAQLGMLLLITHMGTMMSIKELAGQWKTIVIALAGIVGICVGA
                     LALGTVVFGWDTAVIATPPLTGGLVASIMMADAATAKGLASLSVLAILMYVAQGFAGY
                     PITALMLKKEGKRLLSDFRSGKVTVNTDEEKVKDLPEQKSRFKIIPDLPEKYDTTYMI
                     ILRLGFVAWLAVQFTNLTNEVVSRYVICLIFGVIASELGIVDRKPLNKSGSFGWLMTS
                     LMAFIFAGLAKATPAMLVEMAVPLVGIIIFGVIGMGIFSIIVGKLLGESKEMAFSVSL
                     TSLYGFPPNYILTEEAVKALAETPEEKEFLMDKMLPKMLVGGFTTVTIASVVIAGIFV
                     NLI"
     gene            complement(44105..45805)
                     /locus_tag="KR257_001218"
     CDS             complement(44105..45805)
                     /locus_tag="KR257_001218"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418965.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBH0029936.1"
                     /translation="MIKQFVKYYKPYKKIFTLDLIAAFLFSLCDLVYPMITRNIMDDV
                     VPNKNLRMLVVFAVALILIFIAKAGLNYFMQYWGHVIGVDMQADMRNEVFTHLQRLPN
                     TYFDNNKSGVTMSRIVNDLMDITELAHHGPEDLFISIVMLVGSFFILIDINIPLTLII
                     FAILPFIIWFAIAKKDKMNIAFMKSRVTIGDVNATLENSIAGMKVTKSFCTEKEELNK
                     FVRSNKLFRRARQDSYKVMAEYYSGMNLYMDILEWVVVIAGGYFTYIGKITLGDFAAY
                     ILYVKMFIQPMKKLINFTEQYQNGMTGFKRFIEIMEQDHQKEAKNPIELENVKGDIEI
                     ENISFTYEDKTQVLDNLSLSIKAGKTIALVGPSGGGKTTLCNLLPRFYEFDKGDIKID
                     GKSIKDVSLKSLRKNIGIVQQDVFLFTGTIRDNILCGNPNATDEEMIAAAKKARIHDF
                     VETLPDGYDTYIGERGVKLSGGQKQRISISRIFLKNPPIIILDEATSALDNVTEREIQ
                     ESLEELSKDRTNLVVAHRLTTIKNADEIIVLTDKGIEERGTHEELVNKNGVYSRLHNN
                     "
     gene            complement(46060..46335)
                     /locus_tag="KR257_001219"
     CDS             complement(46060..46335)
                     /locus_tag="KR257_001219"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423118.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIB"
                     /protein_id="HBH0029937.1"
                     /translation="MKKILVACGAGIATSTIVCDRVERLVKENNIQAEVEQCKIAECS
                     TKQEGADLIVSTTILPTTYDIPTIKATGYITGINTTALDKKILNALK"
     gene            complement(46454..47026)
                     /gene="mobB"
                     /locus_tag="KR257_001220"
     CDS             complement(46454..47026)
                     /gene="mobB"
                     /locus_tag="KR257_001220"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438013.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="molybdopterin-guanine dinucleotide biosynthesis
                     protein B"
                     /protein_id="HBH0029938.1"
                     /translation="MLLLDSFMKGHNFMYNILSVVSYSGVGKTTLIEGIIKELNKKGY
                     RVGVIKHTCHDFDMDEEGKDTYKHRKSGARKVCIISDKRVAYIEELKEKNPLYKMIQL
                     YEDMDLIIIEGYKNYRFKRLEVTRKGKYEDILSNKSDLIGIVSDIEYKLNIEQFNLND
                     YKNISKYIESCIKNEILSISNVEIKNILKE"
     gene            complement(47010..48191)
                     /locus_tag="KR257_001221"
     CDS             complement(47010..48191)
                     /locus_tag="KR257_001221"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428539.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="molybdopterin molybdotransferase MoeA"
                     /protein_id="HBH0029939.1"
                     /translation="MIELEDAIKIIEKNVLPINRVKIVNLIDAVNKVVAEDIYSTIDS
                     PPFDRSPYDGYAYNANSENRNLKVIGTLYAGDVFNRVLNKNEAVKIMTGGKIPQGANC
                     VIKKEDVTVIGDMITLNIKLKEYDNYIFKGEDIKKGQLIINKNQNIGYDGIGVLASLG
                     ISKVTVYDDLKVGILNTGTELQDINETLENGKIYDSNRYTLYSRLLKLGIQADTICNC
                     SDDILELEKKVKNMLQSVDFLITTGGVSVGDKDLIPDVFKKIGATELFWKINIKPGGA
                     CYVGTLGEKLLFGLSGNPHAAIVVFDNVIVPVIEYLTYKKGTHHIKAIFKGEFNKFSN
                     KDRFVSGKLYTSEGKLYVELNDKKDAKARLSATLRSNCMIKIKKNETIKENQLVDVVI
                     R"
     gene            complement(48402..49136)
                     /locus_tag="KR257_001222"
     CDS             complement(48402..49136)
                     /locus_tag="KR257_001222"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418957.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0029940.1"
                     /translation="MKLKRSLVCVTILGIILVGCHKENTKEKNQVASKATQQKTMTKV
                     QNDVNEIMNKDYKYIIKNMGIPYNTFYYIKPKVLKESNTMQDINTSSYMTLVYPKYTG
                     NDELDGSALYVDINENKVVNVETNSFSSQGISVIDAESSIVIEKSDHEKSAVSLENFR
                     HIDLGEYVGVEDSRINEIVGDANYDLTAYNHEGSKVVKSYRLKEDNKILKKEVLTISI
                     VDNKIKSIKTIESDKIVKIIKGTLLE"
     gene            49498..50403
                     /locus_tag="KR257_001223"
     CDS             49498..50403
                     /locus_tag="KR257_001223"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892888.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LysR family transcriptional regulator"
                     /protein_id="HBH0029941.1"
                     /translation="MDFKQLEVFVAVAKHQSFSKAARELFLTQPTVSAHIQNLERELE
                     TVLINRSNKVITLTKSGEILYEHAIYILNNCKRAIYDIKEYSGKIEGIIDIACSSIPE
                     TYILPDFMKSFSMSYPDVKFSISHYDSQYAISEILNERISFGLVGSKINNPQIEYLDL
                     LDDELVLITPSDFKIDNKNNCIDIGELAYLNFIMRKEGSGTRNLILNTLSKNNFPVSK
                     LNVIAHVESNEAIKEMVRLGLGVSFISYISAIDYLNAGKIKCYKIKDVDFTRKFFFIY
                     SKKKTFSPLEDKFLNRLCEYFEIII"
     gene            complement(50563..51405)
                     /locus_tag="KR257_001224"
     CDS             complement(50563..51405)
                     /locus_tag="KR257_001224"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418955.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS system mannose/fructose/sorbose family
                     transporter subunit IID"
                     /protein_id="HBH0029942.1"
                     /translation="MTTSSKKLETISPDSKITRKDFWKCFRRSLTLDSSWNYERMQNI
                     AYAYMMAPIIRRLYKDDKEKKSKALKRHLEFMSVTPHISTLLVGISGAMEEENAKNKE
                     FDANSINAVKSSLMGPVSGIGDSFFWGTLKLIAAGVGIALASQGNIMGPILFLLIINV
                     PHFIIRYICLDKGFKYGTQFFKDVSGSSIVSKVMEAASMLGLMVIGGMTASNVMLKLS
                     VNVGSGEWAEPIQTYLDQIMPCMLPAMIFGIMYWLLGKKVKTTTILISVMIICIVLAA
                     IGVV"
     gene            complement(51389..52147)
                     /locus_tag="KR257_001225"
     CDS             complement(51389..52147)
                     /locus_tag="KR257_001225"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888882.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIC"
                     /protein_id="HBH0029943.1"
                     /translation="MEFTQVILITLIAFFAYMHSFVGSTMHNRPIVVAPLVGLALGNL
                     HTGIVIGSTLELVFMGAFPVGASNPPDFVSGSIIATAFVILTGQDVSAAVVLAVPIAT
                     LVLLIDNFLMTVVLTWGAHIADRYAEEGNIEGVERVQLLFGIGNKLILAIIVGIGFSL
                     GVPVIEKILSFIPSYVTHGMDVAAGVIPAIGFAMLARMMLNKKTVAFLLLGFILVAYL
                     NITVTGVALFGLAIALIYVNFVGEKEVIVDDNEF"
     gene            complement(52164..52634)
                     /locus_tag="KR257_001226"
     CDS             complement(52164..52634)
                     /locus_tag="KR257_001226"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888881.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIB"
                     /protein_id="HBH0029944.1"
                     /translation="MIKLVRVDHRLIHGQVAFTWTKFLSTDCILIASDDLLKDELRMA
                     GLKMAKPSNVKLVMKSIADSIKALNSGVTDKYNLLILCESVEDVYRLAKEVKAIKSIN
                     LGGTKSDDNRENISKAVHVSKDDIKMIKELDSEGVNVFVQLVPDDDATNVMKLI"
     gene            complement(52634..53377)
                     /locus_tag="KR257_001227"
     CDS             complement(52634..53377)
                     /locus_tag="KR257_001227"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888880.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="membrane biogenesis protein"
                     /protein_id="HBH0029945.1"
                     /translation="MKKKGILSVFKSKKPIIAMIHLKGDTPEDIFERAKKEITIFEEN
                     GVDGIMLENYYGNYYDLERILEYVSKANLSIPYGVNCLNVDTMGFELATKYNASYIQV
                     DSVVGHVKPRDEATLEEFFKLQRSKCPAYLIGGVRFKYQPVLSENDVEEDLKIGMTRC
                     DAIAVTENATGQETSMEKIELFRKNLGDFPLVIAAGVTLENAKKQLKLGDMAIIGSYF
                     KDNYKDFGDVSVEHVKTFMDEIKKIREEL"
     gene            complement(53381..53794)
                     /locus_tag="KR257_001228"
     CDS             complement(53381..53794)
                     /locus_tag="KR257_001228"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896035.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIA"
                     /protein_id="HBH0029946.1"
                     /translation="MKKIILASHGDFSKGLLNAVKMIVGDLADCVSSYGLYPGQSASD
                     FALELEKTISEDKECEYIILSDLYGASVCTAMLRLTNLHNVRLFSGMNLNMVLELLTR
                     FSDELTVEDIDQLVEESRRGIQSVTLQIKEEEEVF"
     gene            complement(53820..54404)
                     /locus_tag="KR257_001229"
                     /pseudo
     CDS             complement(53820..54404)
                     /locus_tag="KR257_001229"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896033.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="GntR family transcriptional regulator"
     gene            complement(54589..54972)
                     /locus_tag="KR257_001230"
     CDS             complement(54589..54972)
                     /locus_tag="KR257_001230"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015984867.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="BlaI/MecI/CopY family transcriptional regulator"
                     /protein_id="HBH0029947.1"
                     /translation="MKISKLPEAELKVMRYIWEANKVLTSRELVAAMEEKYEWNESTT
                     FTVLKRLERREFLSTEKIGKLTHYNILVKEKKYLRFETKEFLKNIHKNSISSLISALH
                     SKDDEVDEDKLIELEEHFKNLKEKE"
     gene            complement(55077..55454)
                     /locus_tag="KR257_001231"
     CDS             complement(55077..55454)
                     /locus_tag="KR257_001231"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861518.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="BlaI/MecI/CopY family transcriptional regulator"
                     /protein_id="HBH0029948.1"
                     /translation="MKEEILIEKLLRAELIVMEYLWKKDTLMPKKEIVKEIKQIYGWH
                     KSTIKILLKRLIDKGYLARDIIKFQSYYKIIIDNEEYYAFKKKVLKSSKSRKIMRSLT
                     TTHKNVSKEKLDSLEEYYKNLKE"
BASE COUNT        17519 a        10299 c         5766 g        22015 t
ORIGIN      
        1 tactctatct ataatctatt tcctaattat ttaatctcaa atttagctct tcatcattta
       61 aatctttcat aagatttcta caggtactag atttattcca acagaaagac tagggcatta
      121 aacacttata tatctgtttc tttagactgt aatattaata ttttttaaat acgttgactt
      181 ttgctttttc taacttctct ccatgatagt tctcctctat caagagcttt tataaatatt
      241 tctgctgaag ctagatttgt agctattgga acatgataaa catcacaaag tcttattaac
      301 gcttgtatat ctgtttcatg agcctgagat gtcaatgggt ctcttaaaaa aataactaaa
      361 tctatttctt gtgttactat taaagaacct atttgttggt ctccacctaa aggaccagat
      421 gctaatctat ttatatttaa ttcagtttca tccattattc tttttcctgt agttccagtt
      481 gcatatagtc catacttttt taaaattgat tcataaccta tacaaaatcc gaccatagtg
      541 tttttcattt ggtcatgtgc tactaatgct atattcatat atctaatctc ctcaatttat
      601 gtttagatgt atttaaattt agaaatttat tttctttctt ctcatacaca catttagtac
      661 taatcctaag tttgctaaag atgtcaataa cgaacttcct ccataactta caaaaggtaa
      721 tgttactcca gttactggta ttaacgcaac cgtcatacct atattttgga ttatctggta
      781 accaaacatt cccataacac caaccactat gagggttcca taaaaatctt ttgcatctct
      841 tgcaattgct aaaagcctta ataggaatat cataaataag attatcaaca ctgccattcc
      901 tattacacca agttcttcac ctacaacagc aaatataaaa tcactatctt gtacaggtaa
      961 aaaatcttct tgattttgac ttccattgta aagtccttta ccagttacgc ctccagaacc
     1021 aattgcaatc agagattgca taacttgata gtttcctttt agagttacat cttctggatt
     1081 tagaaaagct tctattctta ccttttgatg gtctgccatc attaaataca tcagtggcat
     1141 tgacactaat agtatgatta ttcctctttt tatcaacttt gagctaagac ctgctgtgaa
     1201 cagcattgca aatatcatac aacaaaatac aattcctgtt cccaagtctg gttgtgcaat
     1261 caataatccg ataaatggaa gagaataaac tacaacaggc ataacttcct ttaacgtatt
     1321 taatttatcc tttttggatt caagtatctt tgcataactt agtacaaatg ttaatttgac
     1381 tatttcagat gtctgcaagt caagtggtcc taagttaatc cacgacctag ctccaccttt
     1441 tactgtccca attccaggta ataaaactat ggctaacaaa ataagactta ttatataaag
     1501 cgctttataa tacctgccta gaaggttata gtcaaaaaat aatatgacta taatcattcc
     1561 tatcccaagt acaaaagcta atccttgttt aatcaattga ttatatgaac ctgttgaatt
     1621 agcatgtgtt gcactactaa gtataacaag cccaaaaata aagatagcta atactgtaac
     1681 tataagtttc cagtctaact gttttatcaa cttaattgtc gacttataat taatattgat
     1741 ttttttcaaa gaatcaccgt ctttctatct ttaaacatat aattaaataa aaggggcata
     1801 taccaataag gatatccccc ttttaagcac taattacata catctatctt ttatattctt
     1861 tagtggtata ttagcaacta atgcagatac aggtttgtca tcatgctcac ctctgcattt
     1921 agacattttt atttcaagac catcatcttc tatttctgca taattagcta ttacttttaa
     1981 aatgtctgtt tttatcatct ctaaaagttg tggtgaacaa tctactctat catgaactaa
     2041 aactagcttt aacctctctt tagcaacaga tttactagtt ttagcctcgt tagaaaaaac
     2101 tctaaataaa tctaacacag atgtatcctc ctttgctact tagccatgct aaacattttt
     2161 ttaagtctac caaagaatcc atcttcaact tcaagatcaa gtagaggaac ttcttcattt
     2221 agtatccttt ttgcgatatt tttgtatgct tgaccagcaa gtgacttaga atcaagtata
     2281 gctggctctc ctttatttgt tgatataatt atgctttcat catcaggaac aagacctaac
     2341 aaatctattg ctaatatttc tattatatct tgtttatcca tcatgtctcc acgcttaacc
     2401 atatcatttc taattctatt tataactaat cttatctctt ttatttcatt tgcttctaat
     2461 agacctatta ttctatcagc atctcttact gctgatattt ctggattagt aactacaata
     2521 gctctatctg ccccagctac tgcattttta aagccttgct caatacctgc tggacaatct
     2581 attattatat actcgaaaga ttcttttagt ttctcacaca ggtcaatcat ctgctcaact
     2641 gagacagcat ttttatctct agtttgtgct gctggtaata aatatagatt atcaaatctt
     2701 ttgtctttta ttagagcttg cttaagccta caagttcctt caactacatc tactatgtca
     2761 taaactattc gattttcaag acccattact acatctaagt ttctaagtcc aatatctgca
     2821 tccacaacta ctgttttttt attttctagg cttagcgcag ttcctaagtt tgctgcggta
     2881 gtagtttttc caaccccacc tttaccagat gttataacta taacttcgct cataatacta
     2941 ccccctattt ttctttctat ttgtctaact ttgacaaata gctttcgatt acaattcttc
     3001 cattacttac aaaggctatt tctgggctaa tttctgattc actttcataa ttttcttcat
     3061 catctggagc ttctgcaata ttatctgcta tttgtaatat tttaggatta agatttccag
     3121 caacaacata tgcaaattca ttgccttctg cacctgcatg tacaaaacct tctattttac
     3181 ccattacaaa aacattacct cctgctacaa ccttagcacc agcatttata tctcccataa
     3241 caactgtatt tgattttgaa aggacttttg aaccaggttt catatcattc aatataacta
     3301 catcaccttc aaattcaata ttttcaccag atcttagggt attgacatat tttgttggaa
     3361 aattactatt ttcttcaatt ttttgatctt caacaaattc cacatcaaat ctagaagtaa
     3421 ttccttcttt aagttctaga atctccatgt cagttaaaca atcactatta attttactaa
     3481 ttttagcccc attaaaaaag ccaacatatg cttccaattt gtttattatt ttttcctgta
     3541 tttcctcaaa tggagcttct ctttttatat ttactattat ccctctttta ttacccttga
     3601 actctactag ttcttgacta caaatttctc ttaaagacat aacaacctcc agagtgatat
     3661 atcatttata ttcttcaaat acgctttaaa cccttttatt ttttctatat aaagctaaag
     3721 tttatacata gattgagcta tctattaatt tgtgactcga aatttatatt ttcgtcagaa
     3781 gaattgttaa catcattcgt cttgttgtca tttttactat tagttggctc taatcccata
     3841 taagttccaa taacttctct agttggtaaa agtgagaata cacttgaatc accttgagga
     3901 attacacata caacagctat ttctgggtca tctgctggag caaaagcaac agtccacgta
     3961 aaagaaccat aatcttgttt aaatctatct atttggtcat ctgttatttt tggatttaat
     4021 tcttttatag cttttcttag atatgaagaa ttcaccttat cagtgtcctc taatctaact
     4081 tttactccat cttctaattc ttcctctaat ttctttcttt cttcgtcttt caaatcttta
     4141 ttttctaatt tcttttttat ttccttttcc ttagctaatg aaagctcttt ttctttttct
     4201 gctttcatct tatcagctag tttaatcgca tcatttaggt tgacattata agatgacata
     4261 tgacttttta aatattcata ctcgttatct gtaggtattt tcccactttt ctcagctgta
     4321 ccagtttttg ctgctacatc tattggaaaa tcagcaaaag cactcttcgc tgtaccttgt
     4381 cttgcaacca atttcatacc ttttgttaat tcttttaagt tatctggatt tttaaaaggt
     4441 attttttcga ctttcttctg gtcattaatt ttaactgatg aataatcact tgaaacagct
     4501 ctatcaacta cagataattc tactaaatta cctccatttg ctatagcagc tacatatctt
     4561 gatatttgag ctggtgtata agcattttca ccttgtccta tagctaagtt gaatgtatct
     4621 gcagtactcc attttgcaaa attaaaataa ctaaatactg ctaaatctgc tacttcttca
     4681 attctatctt ctttaacatc caattttttt agcctattca ttgtttcaac tctaccagga
     4741 gttttctttt ctgctgccca gcttacaatc tcattgattc ttttctcata ttctttagga
     4801 tttttttctc tagttatatc aacaaaatca tttgccattt ctctttctaa atttgacttt
     4861 agaagagctt gtgttgattt caatttatct tctgtgctag gaactttacc tgctctttct
     4921 tctacttcat cttgaagccc tgtattttgg tcaagcccaa ataattttgc atactcaagt
     4981 attttatttg cattcatatc tataccaatg ctttttccat ctggccatgt tttacctgta
     5041 ccaattgttg ccatatatat attacaagac tcttgtattg ctttatataa gtttgtcata
     5101 ccatggtttc ctctaccatg gttccataca tagtcaccaa aagatttttt acctaacatt
     5161 ataaccccag ggtcatttat agtaaagttt ggatccagac cattttctaa cgctgccatt
     5221 gaagttagca tcttaaatga agaacctggc tgaaattccc cttgtgtaac caagtttaaa
     5281 agtggacttc ctgctagtaa gtcatttgga ttttttggtt gaagtgcttt ataatcctct
     5341 gtagaaatac cttttgcaaa tttatttggg tcataattag gataacttga tgaagctaat
     5401 acttctccat ttttaacatc aatagctata agagctgctg actgtgcttt tcctgcatat
     5461 gcactaattg gtttgtcccc aaatttactt ttaaaagtac ctcctttaga agcaacttcg
     5521 attatctgtt ttaatgcatt atctgaaact tcttgtaaat ctttatctag tgtaagatac
     5581 acagtatctc ctgatttagg ttttttagat tcaatttctt tactgattct acccaatgca
     5641 tcaactttaa ccattttata accatcagtt cctcttaatc tactttcatt actcttttct
     5701 actcctgcaa gacctaccat atctccagtt tcataacctt tttgaaggta tgattctatt
     5761 tgagtggatg gcatttttcc tacatatcct aacatatgag aagctaatga cccattagga
     5821 taatatctta ctggttctac tgctattgaa acaccaacaa ggtccatagc actttcttca
     5881 atttgagcaa tcgtagtttc tcccacatcc ttagcaatag ttactggatt atattgagaa
     5941 tatccttttg attttatcaa atcccttacg accattattt ttcttgcatc ttcatcactc
     6001 aaacttttat caatttctaa tgcatcacta tttcttactt tttcaaacgc ttctttggca
     6061 ctcagtttag tttcttttat cttataacta gccaaccaat ctctcttatc tctttctgct
     6121 gtgaacatcc atttactaac taaaataggt ggataatatc cattttcatt tagttttgcc
     6181 tgtaatcttg tcgcatccaa tcttttatct tcttgagata atattccagc tgatataagt
     6241 ttgtccacca agtaataaaa actttcctta gcattataat catttggaat accattttct
     6301 gatttatatt ccctaatatc tctgtcatat gtataatagt actttccatt ttctacatat
     6361 ataggaaact catctacata ttcttcacca tttctctcca gcaaatttat aagttttaat
     6421 gatatttcat ttgctcttga atgcttattt gcatctttct tattaatatc gttacctgaa
     6481 acttgaacag taaataagtt tttatttcct gccaacagtc ttccatatct atcttttatt
     6541 tctcctcttg gagcttctat tgccaacttt ttatatgttt tattctcagc taactcattg
     6601 taatattcat atttaaatgt agtcatatag attattttta ctaaaatagc taaaaatatc
     6661 acgcccatga ctatcttaat tatttttagt ctatcaactt gtttattttc ttccatgaaa
     6721 tcaccaacta atcttcttta agttttaaaa ctgctctttt agataagcga tatattacta
     6781 aaccaattaa actattcact attggtgcta ctagtagacc ttttacaaaa agtgttgata
     6841 tgttgtagct ttgataaatt atactagatg tacctatatt gacaattgaa tcaattaaac
     6901 tgcctataaa aattaaaacg aaagtaataa tataactacc tttatatagc tgatctctca
     6961 tgtatccaat tgcatatgca ataataaaca aaattaatgc atttacacca aaaattccac
     7021 caacggttat gtctttaata agccctatta ttgctgctat aatcccacct tctaattcat
     7081 ctaaataaag agagattatg gttacatata taagaactaa attaaagctt atgccaaaaa
     7141 tatctatata atttgttata ctattttcta tagtcataag cacaatcccc aacagacaaa
     7201 gtaaaacttt tttcattgtt tttatcccct ttatcctata tttcttggtt ctatgactac
     7261 aacgtcattt atattcttaa aatcaacata aggttttaca actacatatt ttaatgactt
     7321 atctttatca tcaaccactt tttcaacttc gccaattggt ataccatctg ggaagaatcc
     7381 aagacctgat gttgttatta tatctccttg aattacatta tatgatgagt caaacatata
     7441 tccttgcaaa tatcctttac tattataact atctttatta tctaaagtag tattttgagt
     7501 aattgtacct ttagcattgg catcctttgc tagtttaaag cttacagatg ccttagaatc
     7561 caatagtgaa attgccttac tataattgtt ggaaacctca taaactatgc caactaatcc
     7621 actaccattc ataactatac tttctttttt tacacctgaa ttttttcctg cacctatgac
     7681 aaaactctca taccagtttc catcattttt accaacaaca cttgctgaaa tacttgtcgc
     7741 cttatactct tcttgtacaa agttcagtgt cttttttaac tcttctagcg attctgtttt
     7801 atctagtttg gcatttaaag ctatcatatt ttttttaagt ttttcatttt cttcttctaa
     7861 tttttttacc tttttagaat tatctttaaa atttgctaca tctttaaaac catttttgat
     7921 aaaagaaaat ccatcattta ttcccttacc tacacttgta atagcatctg aagctactcc
     7981 taaatttact ggactaccac tagaaaattt accaattgat atacccacaa ttccaattaa
     8041 agtgatagca actacgcccg ttgctatcac tttaacatta atcctttttt tctcattttt
     8101 gttcttgtca aatctcaagg ccatcaccaa cttctaattc ttagtattca tcattaatac
     8161 tttttcaaag atttcttggt cttcaacaga tttacctgtt ccaagtgcaa cacaatcaag
     8221 aggtgtttct gctatttgta cagacatacc agtttcctgt gtaataagct tatcaagacc
     8281 tctaagcaaa gcgcctcctc ctgttagcat tattccgttt tccattatat ctgaggctaa
     8341 ttctggtgga gttctttcta gtgtagattt tattgcatct actattgaac ttacaggttc
     8401 ttttaatgct tctctaactt ctgtagagca tatttctatt gttttaggta atcctgagat
     8461 taaatctcta cctcttattt gcatatttat ttcttcatca tctttaaatg tagaacctat
     8521 gttaattttt acattttcag cagttctttc acctatcata agattatatt ctttttttac
     8581 ataagccact atagactcgt caaattcgtc tccacctatt cttatagatt tagcagtaac
     8641 gattcctcct aaagatatta cagctatttc tgaagtacct ccaccaatat caactaccat
     8701 attaccttct ggttcttcaa cttttaatcc agcccctata gccgctgcca ttggctcttc
     8761 tataaggaat gcatctttag ctcctgcttg tcttgcagcc tcttctatag ctctcttttc
     8821 tacttctgta actccaaaag gaacacatat agctattctt ggacttacaa cacctttttt
     8881 atcagccgct ttttgtataa aatagctaat cattgattga gttatgtcaa aatcagctat
     8941 tactccatct ttcataggtc ttatagctac tatatttcct ggtgttctcc ctatcatttt
     9001 tttggcttct tcacctactg ctaatacctc tttactatca tctcttattg cgacaactga
     9061 tggttctcta acaacaatac cttgtccttt tatgtaaact aatgtatttg cagtccctaa
     9121 atctattccc atatcctttg tcatcttatt aaaactaaaa aaaccttttt tttctttctt
     9181 tttttcctta gccatgattt tactccttcc tactattaag aatcatgttt aaaacattct
     9241 cctattattt tatcacatat aaagtcaaat tatcatattt tctttaaagc taaagtataa
     9301 tccatctcca ataattatat ggtctattat ttctattcca attatttctc cacatttaat
     9361 aagtcttgat gtgatatttt tatcttctct tgatggttct acacttcctg aagggtgatt
     9421 atgcatcact attatcttac ttgcacttct tcttatagct tctttaaaaa cctctcttgg
     9481 atggactaat gacgagctta aagtccctat agatacatct acatcagata ttatctcatt
     9541 ttttgtgttt aaaagaaccg ctttaaaaac ctcttttttt aaatacctta ggctatccat
     9601 ataatacctc tgtatatccc aaggattcct tattttatac tttataggtt taaaactagc
     9661 tactctagag cctagttcta aagctgcttt aatttgggtt gattttgata acccaattcc
     9721 atctatatta cacagctcct ctattgtcat atcttctaaa tgtctaatac cctgaatatc
     9781 tctatttatt atatagttgg ctaattcaat agcattttta ttcttgttgc cagttcttaa
     9841 aagtatagcc aacaactcag catttgataa gctttttacg cctttggcaa gcatcttttc
     9901 tctgggtctt tcctctggtg ccatttcttt taccttaatg gttgaattaa atgacttttt
     9961 cagataaatc acactccata aaaaagattt atactaaaat atttttttaa taggtcgcct
    10021 aaccttgaaa ttggaagacc aactatatta aaataatctc ctctaatttc ttcaactaac
    10081 aaagctccat aaccctgtat accataggct cctgctttgt caaatgactc attagttttc
    10141 agataatcct caatatcctg ctctgataac gttttaaatt tcacattgct gattacatag
    10201 tcaattacct ttttatcttc gcacaagttt attaagctaa tacctgttat gacttgatgc
    10261 tctcttccag atagtctttt taacatatct cttgcacaag actcatcttt tggttttcct
    10321 aaaatagcat tgtctaaaac aacaactgta tcagctccaa taacaacatc ttcattatgt
    10381 tcagatgcta cagacatact tttttcaaaa gctaatctca taactaaatg ttttggtgtt
    10441 tcaccttcca atataatctc atcaatttca tttttaatta tatcaaatct tacattcgta
    10501 ttctctagaa tttctttcct tcttggagag gctgatgcca agattatatt catttattca
    10561 cctcatttgt acgtaatttg tacctattta gtctatcact atattgtaaa aaattcaaca
    10621 gaaatgtcga accttttttg ttacactatt gttatattta ttaccattag aataaatata
    10681 cataaaatag aggtatggaa attattccat acctctgttt tatgtactca ttagagatat
    10741 ggaaattatt ccatatcctt attttgtcca tattacaaaa ttttaatagc tttctttgga
    10801 catttttcca tacataaatg gcatcctaca catttatctg catctacctt atgtttttct
    10861 tttaattctc cctctattgc atcaaactta cattgttttt tgcacactgt acatccaaca
    10921 caaagttctt ggtcaatagt aactttcttt ttcttagtta tgtcacctga tattactttt
    10981 gtagggcatt ttgctacaca ttgcatacaa cctacacact tattagggtc tatcttagct
    11041 attttgtctt caaatattat tgcatcaaat ttacaagctt ttacacacat tccacagcca
    11101 atacatccag cagtacattt ttctttaaca gctttaccaa actctttgct attacactct
    11161 acaactactt cttgactttc tggttttgtg attattatac ccttaggaca aacttcttta
    11221 cattttccac aatttacaca cttttcttca tctattactg ctattccatc aactatagaa
    11281 atagcatcaa atttacaagc atctttacat gttccaagac ctaaacatcc aaatttacac
    11341 atcttagcac ctgagtttaa aacatttgct gctctacaat ctgatattcc ttcatactca
    11401 tatttatctt ttgcacttga acaagttcct ttacaaataa cttttgctac ttgtttctca
    11461 cctgcttcag cacttattcc cattatttct ccaacttttg caccaacatc tgctccacct
    11521 acagggcaac cattaactgg tgcattgcct tcaactatcg catttgcaag acctccacaa
    11581 cctggaaatc cacaacctcc acagttggct cctggaagta ctcctagtat agcttccact
    11641 ctctcgtcta cttctacagc aaacttttta gatgcaaaat ctagtactat cccgaagatt
    11701 aagcccataa ttcctaaaac taatacagct gtaagtatca ccattttcac ccctcttttt
    11761 tatagcttta taagtcctgt aaatcctaag aaagctattg acattaaacc tgctgatata
    11821 agcgttatag ggaaaccttt aaatgcttct ggtatatcag ctaattctag tctttctctt
    11881 atacctgcga atattactat tgctaaagta aatccagctc cggctccaaa tccgtttatt
    11941 attgtttcta ctaaattata acttttttga acattaacta gagctatacc aagaactgca
    12001 cagtttgtag ttataagagg taaataaact cctaatgctt gatataaaga tggactcatc
    12061 ttttgaatta ccatttcaac gaactgaact atagaagcta taaccaatat aaaagctatt
    12121 gtttgtaaga atccagttcc agtttttact aataaaatct gtataaaata agttataatt
    12181 gaagctagag ttaaaacgaa cgtaactgca actcccatcc ctactgctgt atcaaccttc
    12241 ttagaaactc ccaagaaagg acatataccc aagaattgag atgttataac gttattaaca
    12301 agaacgatac ttaaaaataa aagtattaaa ttcatttatt acacctccac tatgcttttt
    12361 tacttcttaa tttattaaat cctgcaaata agaatcctaa tgttaagaat gcacctggtg
    12421 gtaatataaa tattaatact ggttggaaag atgctccaaa taatgtcatt ccaaataaac
    12481 taccatttcc aagtaattct cttactgcac ctattattgt aagtgcaaca gtaaatccaa
    12541 gaccttgacc tacaccatca actattgaag gcatagctcc tgttttgaaa gcaaaacttt
    12601 ctgcacgagc taatattaaa cagttaacaa ctattaatgg tatatatata ccaagagcct
    12661 tatcaagagc aggaacatat gcttttaaaa gcatacctac tattgtaaca aatgtagcta
    12721 taactactat aaatataggt attcttatct tatctggtgt aatttttctt attaaagata
    12781 taactaaatt tgcacatatt aaaactgctg ctgttgaaag acccatacca attccattta
    12841 ttgctgaagt tgtaacggct agtgttggac acatacctat aacttgaaca aatgttgggt
    12901 tctcatctat tagcccattt ttaaatactt tagctaaatt cataattaac cctccttatt
    12961 tattaagagc actattgaaa acatctatag cagcatttac tcctgtagta actgctgtag
    13021 atgtaatagt tgcacctgat attgctaata tttgattatc tgctgttgta cttccttttg
    13081 ctacttcaag aggctcagca gtttttcctt tgtattgacc cttaaatgca tcatccttag
    13141 cttttgctcc aagacctgct gtttctgaca tattaccaat gtcaacacct gtaacttgac
    13201 cttcagatga tatacctacc ataacttcaa tttctccacc atatccactt ggtttagctt
    13261 ttaaagtata tccaaccact tcagaaccat ctaaaccttc atacacttca gctataagac
    13321 catctccaag gcctttgtaa gtatcttcct tcatttcttt aaattctttt gcttctggaa
    13381 ggactgcttt tctaagttca ttatttgctt gtatatttct ttgttctatt actggagctg
    13441 taacctgatt agtagctcca agagctaatg cagctattgc acttatagca agtaaagtac
    13501 cacctaatct caccatactg ttcattattt agccacctcc ccaaatactc tatttctaac
    13561 aaacttatct ataagtggag caagacagtt cactaatagt attgagtaag atacaccttc
    13621 tggatatcca ccatacattc ttataacagt tgttataaga ccagctaata cagcgtatat
    13681 tatttgacct tttttagtca taggcgaagt tgtataatcc gtaagcatga agaatccacc
    13741 taacataagt cctccagcaa acagttgata tattgcgaaa gttatattaa atccacctaa
    13801 aaggaatgtt aatataaata cagttgctat gtaaaatact ggtataacat aatttattat
    13861 gcctttatac attaggtata ctccacctaa taataataat attgctgatg tctcacctat
    13921 acatccacca atattcccta tcatcatgtc agcaagacta attccattgc tagaaatatc
    13981 tgccagtcct gctgctccat ttttcaaaaa gcttaatgga gttgctgtag taactgcatc
    14041 taaattttta cctatccagt taacacctgg ttgagtccaa gcagtcattg ctactgggaa
    14101 tgatgctaat aaaaatgctc ttgcagcaag tgctggattg acaaagttac atccaattcc
    14161 accaaatacc attttaacta ctaatattgc aaatattcct cctactagac acatccacca
    14221 aggaagtgat gctggtacgt taaatgctaa taataatcct gttacaacag ctgaaaaatc
    14281 tcctatagta cttttttgct tcgtaaattt ttgatataaa aattcagtac ctactgtacc
    14341 aagtatacaa aaaaacatag cactcaaagc attaagtcta aagaagtata ctcctgctac
    14401 tgctgctgga aggagtgcta taataacttg tttcattata tatgaagtat cttcattact
    14461 tctcacatga ggagaagatg atactatcaa cttattttcc atcgtttttc ccccttaact
    14521 ttctttattt ctgagcagct tgctttcttc tctttgctcc tatttctctc tttgctgatc
    14581 ttatagattg aagtaatggt cttcttgctg gacaaataaa tgagcaagac ccacattcta
    14641 tacaatccat tgctctatga tattcagctg tgtcatagtc atcttttaaa gaatatgcac
    14701 ttatgaaaag tggttgtaag aatgatggac atacatctgt acatcttcca catcttaaac
    14761 agttttgaat atctggagta cgtgattctt cctcatccaa acataaaatt cctgaagaac
    14821 ctttgttagt cgctatttca gtagtatatt gagctattcc catcataggt ccacccatta
    14881 taaccttacc aatcttctta tcttctttaa atccaccaca ttgttctatt atttctgaaa
    14941 ctaatgttcc aacttttgtt attaggttct ttggctcttt gatgcaacta cctgttattg
    15001 tagtgattct ttcaaccaaa ggcatacctg ttttaataga cttagctatc tgtgctgctg
    15061 tggcaacgtt gtcaacaact gcacctgctg ctattggtaa tccaccagat ggaacttctt
    15121 tgcctgtaca cgcataaata agttgtttct ctgctccttg tggatatttc acttgaaggc
    15181 caacaacttc gatttcgcta tagtctttag ctacattttg aattgcttct atagcatctg
    15241 gtttattcgt ttcaattcct ataaatcctt ttttgacatc taataccttc attaatgctc
    15301 ttaaaccaaa cacaacatct tctggatttt caaccattaa tctgtggtct gcagttaagt
    15361 atggttcaca ttctgcacca tttaatataa ctacttctgc cttgctatct ggtggaggag
    15421 atacttttac atggttaggg aatgtagctc cacccatacc tactattcct gcctctttta
    15481 tgatacctac tatatcttct ttgctcaaat cctctaactg accttttggt tgaacactct
    15541 catgtaattc ttccttaaag tcattttcga taactacaca ttgagctgaa cctcctggta
    15601 cttcatgttg ttcaatagca ataactttac ctgatactga agaatgaacg ttacatgaaa
    15661 caaaaccttg ttgttcacct attttttgcc caaactttac ttcatcacca acttcaacaa
    15721 taggtttagc tggtgcccct atatgttgct gaagaggaat gtaaactatc tttggagctt
    15781 gagctttttc aagtgccttt gtgttagagt actcttttct atatggagga tgtatccctc
    15841 ccttaaaagt taagagtttc attgttttac ccccttatct ataaaaaaac attttttctg
    15901 ccttctataa gtatactata tatattaaaa aatcttaaca attgttaaaa aaatatccgt
    15961 atttttataa tttattttat aaatcaacac ctctatatta agtcaaattg aggaaaagga
    16021 ttgcttaatt aaacaatcct tttcatatag ctttctaaag tccaaatttt ctgtatttta
    16081 ttttatagaa tttataaaca tagagtactc ctgcatggat gataaaagca gacttttact
    16141 tacactatat ttttcttcat ttgctgcttt tgaagctgta tcaatttttt cattcacatt
    16201 ctttacatac tctattaaat tatctttaaa taaacgcatt tcagaataat caatcttttc
    16261 agcttctttt gatatatttt gtgatattgc ctttctattt gtcaaaatag tattatattt
    16321 ttccatatct acattatttt cagcattcga ccaaaaactt gattcttctt taaagtttgt
    16381 tattaattta tttaattctt tagatatact ctctatataa gcgtagttac ttgtatactc
    16441 taaagacaac ataggtgcat ctaagtgtga taaaaatgca tctggaaaca cctttcttac
    16501 actgcttatc tgctttctaa catcattttc atcaaaagag gaataggtct gtattttttt
    16561 tactccatcc ttctccataa ctgaaaaagg tatgtcatta ttaactaatg atgtctgtat
    16621 ttttttcaaa tcatcattat tatctattgc agcaacttga atagtataca tatcccagcc
    16681 ttctatagta gctaatttga cttcttctgg ctctttagtg ttatttaccg ctttttctgg
    16741 attagtttct tgtttatcat ctgaattggt ttgtgattta gattttttcc ctttttttat
    16801 tgaatttaat tcatcagata tatctttata agttatatct gatgaattat ttagaaatgg
    16861 tattttagcc gatacatact ccaatatctt gctatctttt atttttgtat aagaataata
    16921 gccaattaga cacaagcaag caatcgttat aacatattta cgtaaatcaa tcttatgtct
    16981 attattatta aatcctctgt atatcgtttt tcttctattc attagtttgt ccctcccaaa
    17041 attatattat taataaagta tatttttaag agtcacaatt tatgaatata aataattatt
    17101 tcttctaatt ttttaataag aaattgtact tactaaacaa atcttcttgc accaagtaat
    17161 actttagacc aatatgaact agttaaatta tccactttaa ccttattagg attagtctga
    17221 gtaccactac aatggataaa tttactattt cctacgtata tacctacatg attagttgtt
    17281 ccatcaccat cagtgtcaaa ataaactaaa tctcctggtg cataatttcc catagaaatt
    17341 gcacttccaa aattagcctg ttctctagaa actctaggaa tagaaacgcc tacagaatgt
    17401 ttaaaaacat actgtgtaaa tccagaacag tcaaatttat caggtcctga agctccccat
    17461 tgatatggta ttccaataag agtatatgca aaatctacga ttgttgaacc ttttgctgta
    17521 gatttatctg aatttccagt aaatgatggc tttgagttac tattagattg agaattttgg
    17581 ttagatgatg aatttggttt ttcttttgta tcctcattag tctcagaaat ataactggca
    17641 ctcacccatc caattgttcc actcgataac tttaccttat accaaccatt acttttagct
    17701 tttaattcaa caacatctcc accatttaat tttcctatta tagaatagct tgtcccagga
    17761 ccacttctta catttaaact cacagcagat gttaccttac cattcttgcc ttcaattgat
    17821 tcttcgctag atggtttttt atcagaatta ttagtactat ttgaattact agaattgttc
    17881 gttccaacat cttctgatgt tttagaaata tattggctac tagcccatcc agtaactcca
    17941 tttgatagtt ttattttata ccatccattg ctttgttcta gtaactttac tacatctcca
    18001 ttatttgctt taccaactaa tgaatagtta gtacctgcac cacttcttac attcagtcta
    18061 gaactcacat ttactttacc atttccacta atagttgtcc cacttgaagt tggattattt
    18121 tgacttgatg taccttcaga cgaaccactt gttgatatgt attttgcact tccccatcca
    18181 acaacagaac tcgataccct tactttatac catccattag acttttctaa aatctctaca
    18241 gtttttccct tgtataattt tgctacctta tcgcaatcag aacttggtcc acttcttata
    18301 ttcaaggcac ttgctgttac tgttcccttt tcaagagcac ttgcatttat ggagctaaca
    18361 gatactgcta ctgccccaat tcctaaagct gctatagctt ttttcactac tatcactccc
    18421 cccaacaaat ttttatagtc ataaattcat aacattatta tccattttta gtccctacaa
    18481 tttaatgata acttattttc ttattaattg taaagaaatt ataaacatat ccttaaaatt
    18541 agtgattttt aggaagtatt tcaatccaat aattatctgg gtccgctata aaataaattc
    18601 ccatactttc attttcaaaa catatgcaat ctaaatcttt atgaagtttt tttgcctcat
    18661 caaactcctc aacttctaaa gccagatgaa attcattgtc tcctaaatta tatggtctat
    18721 cccaatctct aagccaagtt aattctaatg tatgactagt aatgccatct cctaaataaa
    18781 ctaatataaa acttccatct tctgcttcct tgcgctttac ctctttaagc cctaaagctt
    18841 ttttataaaa atctaaactt ttttctaaat tagtaacatt gaaattgtta tgacaaaaat
    18901 taaacttcat tttgaaatca ctctccaatt tttatttttt ttatattata tcattattat
    18961 aaatttattt aaatcatatt aagttaaaaa tttgaatgat gatgaccaat taccaaatca
    19021 tggtaaatta tttaaaagaa tatgtcaaaa aaagaataag ctctttcaaa tgcataaaaa
    19081 atttataccc aagttatact taatcatgca aattggcaga acttattctt taaaactcta
    19141 acttttaagt ttttctttaa taatataatt tattactttt tttctaatat cttcagcatt
    19201 ataatcatct tctacttcta tatccaaaag ttttgctatt gacctcatat cttctctagt
    19261 ctttgaccta tagcttgata ttaattcatc ttttattttc tctggttcta aaagatattc
    19321 ttcatctcct cttttgaaaa caacgtattt ttgagcatat gaacttctat tgtagtatat
    19381 atatcttgat atttttctta aaatttgatt atatgaaagt cgcttgttaa tatcaagttt
    19441 taagtactct gaaaaagcaa atagctcttt ttttgattta aataatgctt ctttctttat
    19501 agttcttgat attgaagtta cactttcttg atatgcacac ttttttaaca tttttaaata
    19561 tactctatta agaccaatac tttgattgaa tttttttata ttattattaa taatcttatc
    19621 caagttacct tcaaagtatt tttttgctcc tttttgtgat acataactct caagttcttt
    19681 gtgggccata tcaagtatca ttttttttaa atcctcttta tatcccctag attccatgat
    19741 actccctccc ttagctattt atagtatatt caaaaagctc aagaaatgtg agtcattaca
    19801 aaattttttt actttttatg tatatattaa tttaaaaggg gagataatag taatgtaaaa
    19861 tcaaacatac tcaatctccc ccatttttag acctctatta ctcccccaat agaggtcttt
    19921 ttttagttta tcaatttcta ttcaattccc tttagttcaa atcctaattc tgctatcact
    19981 tcttttaatt tttcaataga tacatcatct ttcatatcta cagatgcaca cttattttct
    20041 aaatctacat ctaaaacttc aataccatct atatcttctg ttaatgcagt tttaagatgg
    20101 tttacacaat gaccacaact cataccttct actaatagtt tcttcttcat ttaattacct
    20161 ccttataccc tataagggta ttctatcata tagtttatac tttttaaata gaaattaatc
    20221 atttaatttg attcattcga ttttatatct aaattagata ttccctcata tacatcaaaa
    20281 tcatttggag taattttacc ttttaatcta ctattactta caatatagtt gtttctcaca
    20341 gctaaactta taaatgttgc attatctttt atatatgtct gtacatcttt gtatgctttt
    20401 tttgtttcaa tttcagacgt agaacttgta agtgcagaca tatatccatt taacttatca
    20461 tcagtatatc cactactcgc tataatacta cttgcatctg gtataattga tagtttccat
    20521 ccaactaatg ctaaatcata atttttagaa ttaagagcat tttccatatc cttatctgac
    20581 agctgattta ctgtactatt tattcctata gcttttaagt tttcatttat tatgtttgca
    20641 gtttttattc tctcactatt atctctgttt actattatct ttaagttcat ttcagaaaga
    20701 cttttcttta cttcctcttt ttctctattt tttttctctt cagcttcttt tttgattcta
    20761 tcttcttctg cttttttagc ttttgcttct tcttctggcg taagcttctt tgagttcttt
    20821 ttagctgatt ttttctgatt ttttacttta ttgtcatttt gatttactga gtttacattt
    20881 gcatattcta ccttagcaag acactctatc gccttatctt tattaaactc taaatccttc
    20941 atttcactat tatagtattt tgattttgaa ttaagtggaa aattaactgg agtagcatca
    21001 tccatataac cttcactaat aattctatct ttatctatag agtgtgcaat tgcttttcta
    21061 aaattaacat ctttgaaaaa aggattatta taattaaata atacacactc ataatctctt
    21121 ccttgatatt ttgttatatt aaactctttt tcttgaaact tacttaaatc atttaatgta
    21181 acattggtta tatcactatc aagagccata accatagatg tccttgcatc ttcattaggc
    21241 accataccta cttttatgtt cttcatggtt tttggaactt cttcatagta atctttgttt
    21301 acagataaaa ccattccttc tctttctgta tatgattcta ttttatattt cccatttcct
    21361 atcatattat tattcttgtc atttacatct tttgaatcta aatgattttg agatacaatt
    21421 ggaaaaatta aactatcaat tgaaaaagca tatctagctt taaattttat tgtaaaatct
    21481 ttatctgatt taatattcac agaagctata tttttagtaa attcattata tggactatct
    21541 gcactttttt gaattaaacc aatagtatag tttacatcat ttgaagtaat attttttcca
    21601 tcatgccact ttgcatcttt tagctttata tctatactca ttccatcctg agctatatta
    21661 tactccttaa ctaattgagg aattacattg tagttctcat ctatagtaaa taaactatca
    21721 taaactaaat tcattatata accaacagac ttatcagtat tagttatagg atttatagtt
    21781 tttggagtta ccattgttaa gtttatatac ttagcatcta tagaactttg actttgtaaa
    21841 cttgaatcac tactactttg ttttgtttta gtattactac aaccagctac cataagagtt
    21901 atagctaaaa cgactgttaa gacttttatt ctcttcatta gttttttcct ttcttgccat
    21961 atatcttatt ataatgttcg taattatttt ttactttttc tacatatttt gaagtttgct
    22021 taaaaggtat atcatgtaga ttttcgccat ctttactata ttcattattt tctaaccatt
    22081 ttttcacatt acctgaacca ccattatatg cagctatcac taaatctaat ttaccaaatt
    22141 ctttgtataa cttacttaaa taccaacagc caagtcttat attagtctct gggtcgaaaa
    22201 tatccacatt ttttaaattt agttcctctg ctccccaatc tctagttatg tctaatattt
    22261 gcattaatcc ttttgcttcc ttttttgaaa cagcagaact attaaactta ctttcggctt
    22321 taataacact gtaaactata ttttcatcta aattaaattc tttcgaatac ttttctacat
    22381 actctgaata ttttttagga tataaaaatt tatgtattac tttgctttcc attaatagtg
    22441 ccccaaataa gattataaaa atagatagaa tcaatacttt cttactattc acgccaattc
    22501 tccttcatgt actcaataaa tttatgtgct ttactttcta attcagttat tgttcccgaa
    22561 ttatctatta tataatcacc atatttggat ttttcttcct gactcatctg tgaatttatc
    22621 ctactaagtg cttcctgctc actgcaatta tctctctttt gtattctact aatttgtact
    22681 tcttgtttac aagtaactac taatagcttg tcaaccatat ctaaaaaacc actttctacc
    22741 aatattgccg catctaacac tactatattt tcgccttttt ttctcaattt ttctatttca
    22801 cttattattt tttctcttat tcgtggatga gtcaagttat ttaattcctt aagtttttct
    22861 tcatcactaa aaactatttt cccaagagct tttctattta gagttccatc atcatttttt
    22921 atactttgcc caaaatggac aaatactttt tccaataaca acttatcctc aaatatcttc
    22981 ctggatataa tatcagcatc cactatagga atgttaagat ttctaaatat atttgatagg
    23041 ctgctttttc cacagcctat tcctcctgta agtcctaata tcaacataaa atcacctact
    23101 ttgtctcata ccaagaacta cctacattta aatctacatc taagtgaaca tccatattta
    23161 cagcattttc catttcttct tttactattt tcttaactat atctatttca tcatcaattg
    23221 cttcaactat caactcgtcg tgaacttgta gtataagttt tgatttcaaa ttgttctctt
    23281 ccaatttttt atgaacattt atcatagcaa tttttattat atctgctgca cttccttgta
    23341 ttggtgcatt cattgcaaat ctctttcctc tatttctttc cataaaattg cttgacttta
    23401 tttctggtat atatcttctt ctgtttaaaa ttgttacagc atatccatcc tcactagcct
    23461 tttctactgt tgtgtccata aactctttta ttttatggta tttagcaaaa taactttcga
    23521 tatattcttt cgcctttgga acaggtatat ttaaatcatc agctagacca aagtcacttt
    23581 taccatatat aataccaaag tttacagctt tagctgcacc tctcaattca ctagtaacat
    23641 cttccatagg aacattaaaa acttgtgaag ctgttttggt atgaatatct tcatgatgtt
    23701 taaatgcttc tatcatattt tcatcctgac tcatatgtgc aagaactctt agctctactt
    23761 gtgagtaatc ggcatcaacc aacttacagt tatcatctgc aataaacact tttcttattt
    23821 ttctacccat ttccattttt ataggtatat tttgaagatt tggttctgta gatgaaattc
    23881 ttcctgtagt cgttatagtt tgattaaatg atgaatgtat tctattactt tctggattta
    23941 ttatatttaa aagtccttca acgtaagtag aatttaactt tactatttgt ctatactcag
    24001 ttatcttatc tattattgga tgcttatctc ttaatttttc taaaacatct gcattagttg
    24061 aatatccagt tttagttttt ttaattattg gaagctctaa tttttcaaat aatataacac
    24121 ccaattgttt tggtgaattt atattgaatg gctctcctga taattcataa atttcctttt
    24181 ctaatgtagc tattatttct ttaaattcaa cactcaattc atccaatata cttttgtcta
    24241 cttttatacc ttcatactcc atatgaccta agacttctac taaaggcatc tctacatgat
    24301 aaaaaagacc atccatactc atatccatta gacttctttc catcatagga actgtttctt
    24361 taactgtgca tattatttga cccatatact ctgctaaatc ctcaaattct aaatcctcat
    24421 agtttttaga tttaacaccc tttcctaata attcttcttt tgatttaacc ttttttgata
    24481 aatacttcat agctattgca ctacaatcat atgaggtaga tgaagttgaa tctattaagt
    24541 actcagctat tgttatatca aaatacatat tttctaagtt tatattatat ggttttaaag
    24601 atatataatc atcttttaaa ttatatccat actttttaat ttcattattt gaaaatatac
    24661 tatctaactt tgacacttca tttgaatcta cataatatat tttttctcca tctacactta
    24721 taaaaatata tattatattt ttttcaagta tattaccttg tcctctaaca gtttttaaaa
    24781 taacttgtcc ttttttgttt acttcatcta taaatttttc tatatctttt aattttaata
    24841 tttctatttt ttcttctacg tgttctgtgt catctgaatc gaccaaatca actaatcttg
    24901 ataagagact tgtaaatcca aagtatctaa atttatctaa aagttcatct ttatcataat
    24961 cgccaaaaat catactatct aaatccactt ctattggcac atctcttata attgttgcaa
    25021 gtcttttact ttgaatagct atttctttgt tttcctctat tttctttttt acactacctt
    25081 taagcttatc tgtattctct attagattct ctatactaga aaactctttt ataagcttta
    25141 tacctgtttt ttcacctatt ccaggtactc caggtatatt atcagacttg tctcccataa
    25201 gaccctttaa atcgataaat tgtgttggag tcatctcata tttttcaatt acagaattaa
    25261 agttgtattc ttctacttct ccaacccctt ttttcgttat aagggtagtt gtattatctg
    25321 aagcaagttg aatagcatct ttatctccag ttactatgta taccttatat ccattttctt
    25381 ctgctttttt agaaacagta cctataatat catctgcctc ataaccatct atttctagtc
    25441 tatttattct aaatttatct aaaaggtctt ttaatggctg taattgttct gccaattcat
    25501 ctggcatacc ctttcttcca gccttataat ctttatattc taaatgccta aatgtaggtg
    25561 cttttctgtc aaaagctaca cttatatgtg ttggtttata tatatctatc attttaaata
    25621 gcattgtagt aaacccatat atagcattgg tctttaaccc ttctttatta ttcatttctg
    25681 gaagagcata aaaagctcta tttattattg aatttccatc tattataatt aatttttttt
    25741 ccaaattata tcactcctaa aaattatcta tttttgtaac atatatatta tataccaata
    25801 tagtgttatt taatattccc ataataataa tagtatatta aaattaaata tgttgcaaac
    25861 aatatatttt tttgctataa taatatacat gacatgcccg agtggtggaa ttggtagacg
    25921 cagtggactc aaaatccacc ggactaatac tccgtgccgg ttcgagtccg gcctcgggca
    25981 ccattaaaaa ctcctaaagc tatttattca atagattagg agttttttta tttttgattt
    26041 aaattttaag ttattttttg aaattactgt gtctttttaa aatttatata attatataaa
    26101 tttatcttct agcattaatt taaaaactaa tttactttta tataattttc tattttatat
    26161 cataacttat tacaaccttt tatctaattt attgtataca acaacactac aaataaattg
    26221 aaataaaata agcaatccaa gaacaactaa aacccacttg cttattacca ttacagaaaa
    26281 tacactcaat atagaaacaa taaatataag aattacaaga acatagcaca tgatttgatt
    26341 agtaatacgt ccagctttat cacgtaacat aattcttctt tcatcattca tctctatcct
    26401 ttgatttttt atcttttctt cataatctac tgctctttca ggtttactcc aatacatata
    26461 ttgaagaatc atacatacac ctggacctaa agcagctcca gataatcccc aaataaaagc
    26521 ctcaaatgaa aactcagtaa atgtagccaa taaaacaagt aaaattccac aaataaaata
    26581 tataattcca acatataaca tattcttttt catttttact cctcctcata aataaatatt
    26641 tcttcaatac tcatatcaaa gtatctagct atcttaaagg ctaagatgat agaaggatta
    26701 tacctaccat tttctaatga acctatagtt tgtcttgata cttgcaaaat agaagcaagt
    26761 tcttcttgtt ttatgcctct ttcttttctt atttcttcta atctattttt cacatctatc
    26821 cccctttaat atctcaacta cggaaagtct actttccata attatacaac tatattccat
    26881 ttatgtaaag cttactttcc atatttacaa aaaaataaca gactattttc agcctgtaat
    26941 tttagaattt catgttgttt attaatttta atgttattta ttaattccat attatttatt
    27001 aattttaact tggtttctga attggaatcc aaacttctgt agtataatca ggagcattga
    27061 tatcgccatt gggataaagt tcaatatctg gtaaattagc atacacatac ccagaacttg
    27121 gtaaccactc agtaataatt cttttttgca attcctgtat tgccagagca tttggcattg
    27181 gagaaacaca ttcaaatact gcccatgtgc ctgatggtat taagtattca tgagtatctt
    27241 ctaatacagg cttatctgtt ggagcagcaa tataataatc taaaccctta ctatttgtac
    27301 acacactaac tccaagcaat ccacaaggtt cattatttat taactctgaa agtttatcaa
    27361 ttgttccatt ttttatgcat ttagcccaca acttaggaac tttctcaaag cactcttcta
    27421 caatcatgtt catactttct tttataccaa caatacgaaa ccctttcttt tctacaatac
    27481 gatattgcat ttctatattt ccttttacat aaatgcttaa tgtcatctta ggatatgctt
    27541 ttaaaacaac accctttgct ctagctgcag atggagaaat gttatgtata ttttgaaaag
    27601 ctctattaaa agatgttggt gaatcgtaac catacttctc agatagttct aaaattttga
    27661 tgttactgtt ctgaagttca aatgcagcct tagtcatacg tcttcgtcta atatattcag
    27721 ataatggtac ttctgcaata tatgaaaaca ttctttgaaa atgaaaggtt gaacaacatg
    27781 caatttttgc tgcttctgca taatccactc cactttcgag attttcttca atataagtaa
    27841 tagcttgatt taatttattt atccattcca tttgatatta cctccaagca aattatacag
    27901 tttaataaaa taatacacct ctctattcat gcacaaaatt gtaagcattt aaatttataa
    27961 gcatttttca atcaatacaa taaatataaa aattgtatta tacaataaaa aagttcaata
    28021 acattatatt gtaaaatgtt attgaacttt ttataaaaat taatttaagt gtagttaaat
    28081 taagtattac actatcttat atattacaat atcctactat cttatagtct tctggcactt
    28141 tataatcttt gtctggagta cctaaattcc attttaaatc aaacatagtt gcacttatta
    28201 ttgttgcaaa ataaagcata actataccaa tgtctatttt ttcttcatat aaattagtat
    28261 gaccatcttt tctaacagct aaaactacag tgcctccatc aactataaat ctccatggtt
    28321 gtctatttaa tgtagatgga gctaatcttg catagtgaaa tgcatcaaga agtgctcttt
    28381 cttctaagat ttctatactt gcaacatttc cccattcgtt catataaaca acatcttcta
    28441 cacctagtct agtagacccc ttatctgtta caacttgcat atcagatttt gaataatttt
    28501 gcccagtttt tgtagcattt aatactttag cattacttac attttctcca tatccaatag
    28561 ctataattcc tgttacctct ttatctgaat taattccaag tttttctttt accttttttc
    28621 catcttcaaa agtaacccaa caagaaccaa ttccaagttc tgttacttta aagattatac
    28681 tttctcctat gtaccctgaa ttttcaatgt aattatcttt tatgtcagat aatattataa
    28741 tataacttgg agaatctatc atatttcctt tgtaccctgc tactttatct aaattattaa
    28801 aaacttcact tctattcata attcttacat caacatctat ttctggaact agtttcttac
    28861 aagattctga gtatttctta atttcactaa gatattcttc tttaatatct gtgttcttat
    28921 attctctaac agactttcta tttaatatga ttgttttata atccataatt ttatcctccc
    28981 caaactagta ttgtcttaat tatataccca ttaatatatt attttactca tttatttaat
    29041 aaataaagat tacaattttg taattattat ttattaataa tattccactt ttacattaat
    29101 aatgaccagt tgtgcaaaat ccattgccaa ccaccaaata aaaacatatt ataaaggtaa
    29161 tataaaataa caaacaaatc ttaacaaaaa attaaacttt ttttacacga aagaaggctt
    29221 cccgttgcct tctttatttt tataaaaaaa taagctgttt ctaaaatgat ttcacatttt
    29281 tgaaacagcc aagttattct ataatgacaa ctataatttg aggatgtgag ggagagttgt
    29341 cattataaat ttagggtaat tatattatgt tttaagctag ttctttctat atttatataa
    29401 tacattttat atatgaattt tatatgagat tggtataaat gatatatgaa attacatatg
    29461 tttatattat attaaatttt attattacat tttccacaac aatactcata tgtctccaca
    29521 ttatttggaa tatttacaaa tacaaattct ttacagttct cacaatactt taatatagat
    29581 atagttccac aagtgtaaca ttcaaatatt acacaatcct cattttcctc tactatttca
    29641 aactttttac tatgttcacc acactctggg cacttgtgat tatttacatt cataaatact
    29701 cctccttatt agtatagtta catgtcaaaa acttaattaa tgtattctat attacttatt
    29761 atatattcta taataaatca tattctaata taataaaaca aattaaataa aaaaaaaacc
    29821 ataaatttta aatttatgga ttaattcttg taatgataac tctatttgag gatgtgaggg
    29881 agggttatca ttacaatagg gtattatatt atggttttta agctagtctt tctacacctc
    29941 atatgataca tatgctatat gaattttata tgatttttac ataaatattt tatgaaattt
    30001 aaatttttta gtcattttga aatttgtaaa aagttctcta aaaatccaca gcatcataaa
    30061 cagccaaaat ttaagtaaaa catcataaaa aaatttgtcc aataatttta acaagtaatc
    30121 tcacctcatt ataattattg acacaaactt aaataaacaa tctataaatc ttctataaat
    30181 cttaaacttt ccccctattg atacacaatt tctagtttgt caattttatt ttgcatttct
    30241 aagaaaattt cttcaacaga attgttaaat atattgccta aatagattct tttatctttt
    30301 tgaaatgaat aagattttac actaccatca gaagaaatat ataaatgact ccactctgct
    30361 ccatattttg aaaacctctc ctttgtatct ttaaacctca tatcttctat ttttattgct
    30421 ttttctctgt ctcctcttac tacagtgtga ccccttttta ttaaactggt tatttttata
    30481 tcttctttta atttaatacg tgtatcatca ttttttgaat atactttcca tatcacttta
    30541 tgacgataat tatctaattc ctttattaag cttctatcaa tagtaaaact atctttagtt
    30601 accacaatta aatcaaaatg gtctaacata tattgaaata tttctctcat acttttattt
    30661 tttaaaatat cctcaccaat aacctctata aatctacagc ctttctcata catgcagttc
    30721 aataaacttg tgatttcaga aaaataatca tttgtattat tatctccatc tatttctata
    30781 gtaaagtaca aaggagtaat gtatgattta tttcctgtta tctcaaatac acttgatagt
    30841 gtctgtatat catcttcaaa cgttaagtac acattctcat aaaacataaa aaattccata
    30901 actttttctt tcatattatg gatatttcta tatctattgg ataatatatt tattatatcg
    30961 tcagtagtat ttttcccatc acattcagcc agtataacaa tttgcttcca acttaagcta
    31021 tccacatttc cgatactttt tttatatcca tcttcttcgt cataaatagg accaattata
    31081 atgttttctt ttggccacag atgaacccta gttccatctt ttaatttcgg atatttattt
    31141 tttacagact cataaaatct acttgtatca cccatgattc tttactaccc cccatagttt
    31201 aaatattcta tgctaaaaat agcactttat ttttattaat tcaacaatta ttcaaaattg
    31261 gtcattatat atgtttaaat ggatttaaca tcaaccttat ttatatgtta ttgatgttta
    31321 tatatgttat ataaaatctt atttctcata cttaaatgta atcttaacta tctctggttt
    31381 acaattaagc ctaattaaaa cttttgagcc tcctaagcct ttatttaaaa tcatagtgct
    31441 attatctttt tcatattttc cccagtcata cttaggaaag aactctctat ttggagataa
    31501 tacacctcca acaaaaggta ttcttattat acctccatga acatgtcctg ctaaaaccaa
    31561 atctgctccc cattttgcat atttttcaaa gaaaaatggt gtatgtgcta aaagaatgtt
    31621 atattcattt tcattaactt tacctagatt gtcttctaca aaattgtcac ttagttctaa
    31681 ttttttgtta ttagcaaata aatatggata gcattccaat ggtataatta aaccatataa
    31741 attaagatgg ctattacctc tatatattct tacagattca ttttccatat ttattatttt
    31801 ctttgaatat agttccttaa aataatcctt atatagatgt ttatactttt ttattaaaga
    31861 tttttgttca tgatttccaa ttatatgata tacttcatat ttttcaacca aattatctat
    31921 taaatctaat gcaacttgaa aatttttatt ttctccatct actaaatctc ctgttataaa
    31981 tataacatct gggtttaatg attcaatttt atctatcaat accttattat ttttatcaaa
    32041 caccttatta tgtaaatcac tcacttgaac tattttaaag ttatcaaatt cctttggaat
    32101 ttttttgttg aaaatagtat attctgtcgt ttctatatgc tgagtttcat acttatacag
    32161 aatatacaat aatattaata ctaatactgt cattgaaacc tttataatca tattctcttc
    32221 ctctttattc tattttgtta atattattat aatgctttta tgtttttttt aaaacaataa
    32281 catcatcaca tacatataaa tcttttcgac attataaaaa taagttatcc ttttctaaaa
    32341 ttttcattta ttttagaaaa ggataactat aaaattatct ataaacctct atattgtgaa
    32401 atatagtttt tcctttattt aaatttttat atatatgctc taaagttcca tcaaacctaa
    32461 tagaatgtcc agactctaaa atataagttt tcccatccac attaaggtca agtttacctt
    32521 ctattacgag cacatattct tctaaaacat gactatgtgt agatgaaaca tgagtacagt
    32581 tttcctcaag ctcaattata aaaagttcaa accttctttg agggctaaaa gggtatattg
    32641 gatataactt catgttccct ttttgctcaa caataggctc tacttcttct ttctttataa
    32701 cctcataggt atttgtattt tcatttaata gtgtagtaaa atttatttta aatccagatg
    32761 aaattttcca taaagtagat actgtcggac ttgattcacc tctctcaatc tgtccaagca
    32821 ttgctttact gacacctgtc atctttgaag ctttgtctaa acttatgccc atttcttgtc
    32881 tcaataacct taaattttct cccacattag gaaatttatt atccatgtta aaatcctcct
    32941 gatagctatt tgtattctat gatttttact cctgtaagtt ctactatctc ttttaatttt
    33001 aacatatgat tgttacaaat atcatcaaat tcatatatat aatcttcaag ccctaatgcc
    33061 ttatatttat cgattccaaa tttatgatat ggaagtaact ccatcttgcc tcctggaaca
    33121 ttttgtttga caaataatgc agtatttctt atattttctt cactatcatt tactccataa
    33181 ataattggca ctcttataac catagattta ttcaactttg aaagcctaca tatattatct
    33241 aatataattt tattacttac tcctgtatat tctttatgaa tattatcatc catagatttt
    33301 atatctacaa atatgtggtc tattttctca aatacatcat ttaccttatt ccaatcaaaa
    33361 tatccacaag tttcaattgc aatatttatg cctttatcat aaaaaatatc aactaattct
    33421 cttaaaaaat caatctgaag tgtaggttca cctccagaaa aagttatccc tccattagat
    33481 tcaaagaaaa atataaaatc tttttcaact tcctctacta tttcttcaac actcatttct
    33541 tcggtcatta tacaaatggc atctttaaga cataccttga tacactctcc acataaatca
    33601 catttattat ttatttgcgc tctatcaaat agtgaactta tattttgagg acaaacatct
    33661 atacatctat tacaggatac acatttatct ttcataacac ctaattttac tatgttactc
    33721 caggaatctg gattagaaca ccacttacat tttaatttac atccttctaa aaatatagta
    33781 gtccttattc catctccatc atttactgaa aaatgttgta cttttacaac tctacctttt
    33841 ttactcataa tctacctcat aattaaaaat tgctatgtga atttctagct attatagcat
    33901 cttgcatttc tcttgataaa ttaacaaatt gagtactata tccagcaacc ctcactaata
    33961 aatctttata ttcttctgga ttttcttgag cttttaatag agtatcattt gatatcgtat
    34021 taaattgtac atggaatcct cctaaagcaa aatatgattt aatcatagat gttagatttc
    34081 taagtcctct ttcagtttcc accaaatctt gattcagtct taaatttaga agtgttccac
    34141 cagtatgaac atcatgattt atttttgatg cagatttcat tgctgctagt ggacttgttg
    34201 tatcagtacc aacaaatgga gaaactccct ctgtcaaagg ttttgtcgct tttcttccac
    34261 aaggagttgc acctactatt tttccagttg gtacatagtt tgatataccc ataaatgcac
    34321 tattaaattt agagccaaaa atatccttgt attttctagt ttcagtataa taaaaatcag
    34381 aaacttcaat tgctaatgaa tctacataat cattatcatt tccatactta ggaacatcca
    34441 acgcaagttt tcttaattct tcataacctt cccaatcatt atttagtgct tttgttaatt
    34501 cttctaacgt agtcacctta tcctcaaata ctaatttttt tatagctgcc aatgaatttg
    34561 aaactacacc taaccctata ccagttaata caggacctat attatatttt gctcctcctt
    34621 tacttaaatc aactccctta tccaaacatc catctacaca agtagataaa aatggtcttg
    34681 gtaccatttc tttatgaatt tgttgagcaa cagtagttcc tataacagaa ctttttacaa
    34741 gatatgctaa ttgctttaaa aactcatcct taagttcttc aaaagaagta aattctgtga
    34801 tattttttgt atctaacccc attttttctc cagttaatct actcttacct tcattcatag
    34861 catattctaa agctgctgca aaattgatat ttacggctga agtccactgt cctgtttttc
    34921 taaaatgagg aactacacaa ccacagttac tccaatctct agcatcttct gcatcatatc
    34981 catcttgtaa taacatttgt gcccctgcac tatcgctgtg tatagcaggg aaaccagttc
    35041 cttgttttac caatttagca actgccatta cgaaattatc tggtgctcct tgactcactc
    35101 taacacttaa tcctggttgg tgagttttta cactttctgt agcctttaaa cacatatatg
    35161 agatatcatt cgttccatca gtaccatttc tctttttacc accaacagta agattttgga
    35221 attgattata tcctgcaaag taatttgctg tatttgctga tatagtccat acccattctg
    35281 ataacttaat ccaaagtgct tctatcaatt cttgagcttc tgattcagtt attttacctt
    35341 ctctagcatc attttcataa tatggataca tatattggtc aaatctacct aaatttaatg
    35401 ccaatggatt ttctgataga ataccaccta attgaacaaa ccatacaaat tgtattgctt
    35461 cataaaaatt agttggaggg tttgctggta cattcataca tatctctgaa atttttataa
    35521 gttctaactt tctcttttca tctgtttctt gcttactcat ctcttttgca agatttgaat
    35581 atctttgtgc caatgtcata ataccctgtg caactataga aacagatttg taaaaatcta
    35641 tcttttcaat attttctgaa actgatatat ctaattcttt aattttttta tctgcatctt
    35701 ccttaatccc tttatatcct tttacaaaca atatatcttg ataatctggt gttacttcac
    35761 caactgcctg tctccactta gaatcattat ctattattcc tgtatctact aatatcttag
    35821 ctgtatcttc tgggattctt gctaagaaaa cttcttccaa agattttccc ttccaatatg
    35881 gaaatatttc ttttcttata aattctattt gttcttttga tattacatat gggtcttgag
    35941 ttcttttatc aaaagtatcc atttctttgt ctacccattg ccaagaaaac tctggtgtca
    36001 atatccctgt tcttctaaat tttcctgctg tacctactat taattcattt tcaaagattt
    36061 ttataggaag ttctttacat gtctccaaaa aagctttagc tcttcttata cagatagctt
    36121 ctccctcagt ttttttatgt gattctgtaa aaattctagc cctttcacaa catatcatag
    36181 gtttagaatt aatatattct tgtctaaatg cttctattct attagtttga ctcatttaaa
    36241 atcccccttt ggataatata tactacattt ttgtatgtta taacatactt taattatatt
    36301 atactgtcct ttagcataaa atggaagcaa aataacttat tttttttcat ctaccttgaa
    36361 cacctatata ttaatacttt ttttgttaaa tttataaact ctaaaaaaat tttctatgat
    36421 atattttcta tattgttata gttatttcta atatactaat gatttgaaat atcaaatttg
    36481 tatactagac ttagttttaa aaccttagtt gattgtttaa ctttgttaac ttcaacatgt
    36541 atatccttca tataaggaag ctctacaaca cctactccct tattaaagtc ttcttcaacc
    36601 atagaaaaaa tttctttctc agttaagttc gtattagtca atgacttaaa taaattgtat
    36661 ataaatttaa tatatttatc actctcagat aacttatcat cttctggata ctctttagca
    36721 cagagaatat ctattgttac ttttccttct ttatcgtctt cagacataga atagaataaa
    36781 cttcgaatat ttttttcagg tggtttttca gcaccattta tagatactac aaagctacca
    36841 tctgattttg agtcagtaat actataacca ctgtctatta tagctttcga aaatctttga
    36901 gataaatctt tttttacttc ttctctacct ttcgcatcat taatcttttg tgagtaatta
    36961 ttaaaaagct cgatagattc atctttttta tcttcaactt gttctttcaa cgaatcttta
    37021 ctaatttgtt ctgagctact taagttctta tcatatacag gagacataca ccctaccatc
    37081 aatgctaagc taagatttaa agccacaatg attgccactc tatttatatt cctttttact
    37141 ttcatacaca atcctcccat cacactaacc gctctaaagt attacttatt gcactagaat
    37201 atgtttatat tttctttata ttaaagattt attattcaat acatatcacc ttcctatcca
    37261 attcttataa cttactatta gtaaaattat aagctcctta atacagaaat aaggatgtta
    37321 tcttttgtta ttaaaagata acatccttat ttttttgtat caatacatat gtcccaactg
    37381 gtaacttaat cgccccaact gtcagtatct tggtccaatg gtatatatat atttagtata
    37441 aatttatcga tactattttc aaataataat tctccattat atttttgtaa agaagattta
    37501 atactctgaa tacctattcc atgtacaaac ttatccattt tgtttgttaa caatatattt
    37561 ttattaaaag taagctgatt tagtttacta ttttcacatt taagtacaaa aaatgacctt
    37621 gtcatagttc ctttaattct aatatattta ttaacatttt catccactat tttatcacat
    37681 gcttctattg cattatccaa aatattagaa aatatgcttg acacatctat aggttttaca
    37741 aaatttactt ttgaaaaatt tatagagcaa gtaaatttaa ttcctttttt taaacatatt
    37801 tcactctttt cgttgattat aatgtctaat atcatatttc ctgtattata gatatattta
    37861 aatgttttta tttcatcttt taaattgtta acatattcat taatttcttt gctattgttt
    37921 ctaaggttgt ctatacaata aatgtgatta tttatatcgt gatatagttt cttaactcgc
    37981 atatgagatt cttgaatact taaataatgc gcatattgca tatctaactt attttttatt
    38041 aattcagctt gagattttaa tctattctct tttattattt ctttaaacaa tagtataaga
    38101 aatatactac tagctcctac caattttgga ttaacaaaat tatcaaaata gtatccttct
    38161 gaatgtaatg acccaaaccg ttctaatttt tttaatacat aatttacaag catattcatt
    38221 gtattaacta ataaggcaaa taataaatat acataatttc tcttatcttg gctaattaat
    38281 tttatagact tcctaaaaaa gctaaatata agatatataa gaataattat taaattacta
    38341 tatatctgaa tttttataga ttctaagtga ggtactaata aggattcttt agatgaaata
    38401 acattacctg taattgcaaa aaatagtatt ctatatataa cagcatccaa acatttataa
    38461 tatacactaa atagataaaa gaaaatggaa tacttaatat aacccatctt ataaaaataa
    38521 ttatagtatc ctccccaagc aataaatgct aatatataaa ataaatagtt tatattacta
    38581 aagtaatttc ctccattaaa taatctactt atctgaatta taatataaat aagaaacaag
    38641 acaatataga atactatttt ttcatttttt ttactatcct ttttataaat taaaattccg
    38701 ttcattatag aaaactgtat aaatatagat aaaactacta atagctcagt cataaagttt
    38761 agcatattgt atcaccaaga aattttaaga atttctcctt aacttcttta tatctatatc
    38821 tactaatagg tacctcttct ccactttcca gtattgcagt attaggcttt atattttcaa
    38881 catatcttaa atttactata aaacttttat ggcatcttat aaatttatat ggatttaatt
    38941 ctttttctat tttgcctaaa ctatatttta tatcaaaatt cttgtttatt gtgtgtatta
    39001 gcatatcttt tttttgaact tctatatatt ttatttcatt taaataaatc ttatatgtat
    39061 tagacttatt ttttattgta atatgacttt ccttatttat ttcaatatct ttgatacaag
    39121 ttagcacatg tttttttagt tcttccaact ctattggctt tagtaaatac ctataagctc
    39181 ttacctcata accttcttgc acataatcta ttaatgaagt tacaaatatt atttccattt
    39241 cattgtctac ttctctaatc tttcttgcag tatccattcc atttaatttt tccattttta
    39301 tatcaagaag taatatatct atatctttta aattactttc cagtaactct tctccagata
    39361 tatacttttg tatctcatat tctatactta tatcttttaa tatattctca aggtaatctt
    39421 ctattaaaag ttgtgtttct ttttcatctt cacaaactgc tatcttaatc ataaaatgcc
    39481 tccttacata atttctagtt aatacaatta aaatatttat aatatattta aagataattt
    39541 tgtatatctg atactttagg ataacatttt caaattattt ttatcaatac tcaatcccat
    39601 ataactatta tttgatattt caatttaaag acagaaatta ctataattaa aaacagtact
    39661 tactgataaa agaagatgtc ttaaactatt aaaaaaataa ttttaggaca ccttctttta
    39721 tttatttaaa ctttttaagc cttaaataat acattaatct cctatataat tgtactgcat
    39781 ataaaatcaa caatataatc tgtagtacaa tagcagttac agatgctcca taaccactat
    39841 ataaatttct tatttcaata ttcaataaat atataaatat tactactaac ataaagaata
    39901 taaacatatt cataaataaa attgacttta ctttgttttt tttatcagaa tcactatata
    39961 atttaggagg tatgtctttg tattctttcg accatatata ccatgcagat gtacccataa
    40021 aactaccaat actcctaaat acaagattcc agccatttga tttatgttca tcaaaataat
    40081 tattctctac atcatagtag taatcaacag tgtattttat ttttcttgga cttcccttat
    40141 gaaaataaaa tattcctcca aatttattta tcttatataa attatatcct ttagcttcaa
    40201 tatcttctaa ccatttctct atcttatcag gtgaactata ccagtcaaat ttgaatttta
    40261 ttttcttttc catagcactc attctccaaa atgatatttt taaatagctt aaaaatctat
    40321 ttaaataatt atatcatttt gatactaatt ttaggttaca atcatatatt taaaaagcta
    40381 tttaaatagt aataaactaa tagccataac acccattcct gcaatcaatc cataaataga
    40441 taaatgatgt tccccgtact ctctagctga tggcaataat tcatctagtg atatgaatac
    40501 cataattcct cctacaattg caaatacaat tccaagagtt atatcattta aaaaatttct
    40561 aagaagtaca tatccaataa tcgctcctaa aggctcagac ataccagata aaaaggaata
    40621 ataaaaagct ttctttttat ctcctgtggc ataataaact ggtacagata cagatatacc
    40681 ttctggtata ttgtgtattg caattgcaat tgctatcgga atagctattg taacatcatc
    40741 aagagctgat ataaatgtag ctaatccttc aggaaaattg tgaattgcta tagccattgc
    40801 tgtaaatata cctgttctca aaagagactt attttttttg atattctttt cttctatatt
    40861 ctccattttc tttatttcat gtggattttc ttcttgtgga attagcttat caataacagc
    40921 aatgatagcc atacctataa aaaaagctat tacagttgac caacttccta atttctctcc
    40981 catagatttt gtcaaagcat cttgtgcttt aggaaaaatt tctatcatag aaacataaat
    41041 cataacacca gcagaaaatc ctaagcttat agaaagaaac ttagtatttg tttttttagc
    41101 aaaaaatgct atacaacttc ctataccagt agataaacca gccaataatg ttatcaaaaa
    41161 tgcaaatatt acattattca aataaatcac cttcttttta attgatattg attatcattt
    41221 tctttatgct atcatatata ttttatatag tcaatattta taaaaaatat acacaataaa
    41281 aaagcagaga tataaactta gtctctgctt tttctttata gtatattaaa attatttatt
    41341 taagaaatcc actgcatatt gcacatataa agcagttcca atttctagag catcttcatc
    41401 tatattaaag catccatgat gatgaggata acaagcacct tttgactcat ttctagctcc
    41461 tacaaatgct agtgcaccag gtgctatatt cataaactca gctaaatctt ctgctcctgt
    41521 tactttttca aatagtgtta tacagtcttc tccaaatagc ttaattgctg catctgtagc
    41581 tatctttgaa cattctttgt catttataac tgctggtgtt aagtacccat actctaattc
    41641 agcatctgct ctatatgctt ctgctgtaga ttttgctata cgttctaaaa ttccaggaat
    41701 ttgctttcta agctctggat taaatagcct tattgtacct tctaagacag cttcactcgc
    41761 aattacgtta aatctagttc cagaatttaa aactccaaca ctcacaacta atggttccag
    41821 aggacttact tctctactaa ccatagattg tagattcata actattgctg aacttgcaag
    41881 cactgcatca acaccttgat gaggaagtga accatgacca cctctacctt ttacagtaat
    41941 tttaaagaaa tcagcagaag ccattcttgg tccttcttct accgatatgg tcccagattc
    42001 tacatcagtc caaagatgta ttccaaacac actatctaca ccttccatag caccatcttg
    42061 aatcatagct cttgcacctt taccaacttc ttctcctggc tgaaaaaata attttacagt
    42121 tccattgata ctatccttaa tatcatttaa cacttttgct gcccctagaa gcattgatgt
    42181 gtgaccatca tgaccacaag catgcataag tccttcattt ttagatttgt attctacatc
    42241 agtgcattca acaacttgta gagcatccat atcaccccta agtgctacag tctttcctgg
    42301 attagctcct tttatagttg caattacacc tgtacctcca gctgatacat atggtatccc
    42361 tattttatca agttcttctt taactctctt tgatgttctc acttcttcca tacttttctc
    42421 aggattttca tgaaattccc ttctaagctt aattacatag tctttataac tctttgttat
    42481 ttctttaata tccattccat acctccaagt agtacacatt cttcttattt aaaatacttt
    42541 ttatcactta aatactatat tagatttaca aagatacctg ctattactac agaagctatt
    42601 gtaactgtag taaatcctcc aacaagcatc tttggaagca tcttatccat taaaaattct
    42661 ttttcttctg gtgtttcagc caaagccttt actgcctctt cagttaatat atagtttggt
    42721 ggaaaaccat aaagtgatgt aagcgaaact gaaaaagcca tttctttact ttcacctaaa
    42781 agcttaccta ctataataga gaatattccc atacctatta caccaaatat tatgattcct
    42841 acaagaggaa ctgccatttc aacaagcatt gctggtgtag cttttgctaa ccctgcaaat
    42901 ataaaagcca tcaatgatgt cattaaccat ccaaatgaac cagatttatt aagtggtttt
    42961 ctatcaacta ttccaagttc tgatgctatt acaccaaata ttaaacatat aacatatctt
    43021 gatacaactt catttgtaag atttgtaaat tgtactgcta accatgctac aaatcctaat
    43081 ctaagtatta tcatatatgt cgtatcatat ttttctggta agtctggtat tatcttaaat
    43141 ctgctttttt gttcaggtaa atccttaact ttttcttcat ctgtatttac agttactttt
    43201 ccacttctaa agtctgataa aagtcttttt ccttcttttt taagcattaa tgctgtaata
    43261 ggataacccg caaatccttg tgcaacatac atcaaaattg caagtactga taaacttgca
    43321 agaccttttg ctgtagcagc atctgccatc attatagatg caactagccc tccagtaaga
    43381 ggaggtgtag ctattactgc tgtatcccat ccaaatacta ctgtccctaa tgccaaagca
    43441 cctacacata ttcctactat tcctgccaag gctattacta ttgttttcca ttgacctgct
    43501 aattccttaa tactcatcat agttcccata tgagttatta acaaaagcat acctaattga
    43561 gctaatggtg ttcctaaagc ggctaagtcc acaatatttt ctgggaaaaa agtccaaaat
    43621 cctactataa atataattgc tgatacaaaa accgacggaa caaaagcttt agtttttgct
    43681 gaaactatat ctcctatcgt cagtgatact aaaactagac aaaaagctgt tattgcctcc
    43741 atacaaaatc ccccctcata ataaatatat ttttataaaa tgtatgtata gttatccatt
    43801 attttactac ttttgaaaaa catttcaagt caaaattcga tttttttcat aaaattcgat
    43861 aaattccata aattaaagtt agttttctaa attattcttt ttgtaaaaac gttatcccga
    43921 ccattggcta tttaactcta ttcttacaaa gagaattaaa tgtaatttgc aaaaaataaa
    43981 acataggata cattttattc ataaaacatc ttataaatat aaaatgaatt gtctttatga
    44041 atcttaatat atcctatgtt tgtaagttta atgtgtatgt tagctatggt gtaaaatttg
    44101 tatactagtt attgtgtaac ctactatata ctccattttt gtttactagc tcttcatgag
    44161 tacctctttc ttcaattcct ttatccgtca atactatgat ttcatcagca ttttttatag
    44221 tagtcaatct atgtgcaaca actaaatttg ttctatcttt acttaattcc tctaaagact
    44281 cttgaatttc tctttctgtt acattgtcta aagcagatgt agcctcatcc aatattatta
    44341 ttggaggatt ctttaaaaag attcttgaaa ttgaaattct ttgtttttgc ccacctgata
    44401 attttacgcc tctttctcct atataagtat catatccatc tggcaaagtc tctacaaagt
    44461 catgtattct agctttttta gcagcagcta tcatttcttc atctgtggca ttagggttcc
    44521 cacaaagaat attatctctt atagttcctg taaataaaaa tacatcttgt tgaactatac
    44581 ctatattttt tctcaatgat tttaaactaa catcttttat actctttcca tcaattttta
    44641 tatcaccctt atcaaattca taaaatcttg gcaataaatt acataatgta gtctttcctc
    44701 ctccagaagg tccaactaat gctatagtct taccagcttt tatagataaa cttaaattat
    44761 ccaaaacttg agtcttatct tcatatgtga aagatatatt ttctatctca atgtcacctt
    44821 ttacattttc aagttcaata ggatttttag cttctttttg atggtcttgt tccattatct
    44881 ctatgaatct tttaaaacct gtcataccat tttgatattg ctctgtaaag tttattaatt
    44941 ttttcatagg ttgtataaac atttttacat atagtatata agcagcaaaa tcacccaaag
    45001 taatctttcc tatataagta aaataaccac cagctattac aactacccac tctaagatat
    45061 ccatgtataa attcatacca gagtaatatt ctgccattac cttataagaa tcttgtcttg
    45121 ctcttctaaa taatttattg cttcttacaa acttatttaa ctcttctttc tcagtacaaa
    45181 aagacttagt taccttcata cctgctatac tattttctaa agtagcattt acatcaccta
    45241 tagtaactct actcttcata aaagcaatat tcatcttatc ttttttagct attgcaaacc
    45301 aaattataaa cggtaatata gcaaatatta taagcgtaag aggaatattt atatctataa
    45361 gtataaagaa tgaaccaacc aacattacta tagaaatgaa taaatcttca ggcccatgat
    45421 gtgcaagttc tgttatatcc attaaatcat ttactattct agacatagtt actccagatt
    45481 tgttattatc aaaatacgta tttggaagtc tttgtaagtg tgtaaatacc tcatttctca
    45541 tatcagcttg catatctaca ccaataacat gtccccaata ctgcataaaa tagttaagcc
    45601 ctgcttttgc tataaatata agtataagtg ctactgcaaa aactactaac attcttaagt
    45661 ttttatttgg aacaacgtca tccattatat ttctagttat cataggataa actaaatcac
    45721 ataaggaaaa tagaaaagct gctataaggt ctagtgtaaa aattttctta tatggcttat
    45781 aatatttgac aaattgtttt atcataagta ttaaatccct cctttattag tacttctatt
    45841 agtacttcta aaaaataccc ataaattagt ataacataac aataacttta aatcttttat
    45901 aaacttacaa agtaataaca atctttttca taaaattgaa gatttatatc atatagttgt
    45961 atacttgaaa caacataaaa agagctatat ctctatattt aaaattttat aaagatacaa
    46021 ctctatattt aatactaaat tttttttata aatacaaaac tacttcaatg catttaatat
    46081 ctttttatct aatgctgttg tatttatacc tgttatatat cctgttgcct ttattgtagg
    46141 tatatcataa gttgttggta gtatagtagt agatacgatt aaatcagcac cttcttgttt
    46201 tgttgaacat tcagcaattt tacattgctc aacttctgct tgtatattat tttctttaac
    46261 caatctttct actctgtcac aaactattgt tgatgttgcg attcctgctc cacaggctac
    46321 taatattttt ttcatatatt gtcctcctac aatttcttta atattttata actcaaaata
    46381 aaattgataa atttcttata tctttattta tataaataat tatatcattt tatataagaa
    46441 gaacatctta aaattattct tttaatatgt tttttatttc aacattgctt atacttaaaa
    46501 tttcattttt tatacaagac tctatgtact ttgatatatt tttataatca tttaaattaa
    46561 actgttcaat attcaattta tattctatat cactaacaat acctatcaaa tcagacttat
    46621 tagataaaat atcctcatac ttaccttttc tagttacttc cagtctttta aatctataat
    46681 ttttatatcc ttctatgata atcaagtcca tatcttcata taattgaatc attttatata
    46741 atggattctt ctcttttagt tcttcaatat atgctactcg tttatctgat attatacaga
    46801 cttttctcgc cccagatttt ctatgtttat aagtatcttt tccttcctca tccatatcaa
    46861 aatcatgaca ggtatgttta ataactccaa cacgataccc ttttttattt aattctttta
    46921 ttatgccttc aatcaacgta gttttaccta ctcctgaata tgagacaact gacaatatat
    46981 tatacataaa attgtgtcct ttcataaaac tatctaataa caacatccac taattgattt
    47041 tcttttattg tctcattctt tttaatctta atcatacaat tacttcttag agttgcagat
    47101 agtctagctt ttgcatcttt cttatcattt agctctacat acaatttacc ttcacttgta
    47161 tatagttttc cacttacaaa tctatcttta tttgaaaatt tattaaattc tcctttaaat
    47221 atagctttta tatgatgtgt tcccttctta tatgttaaat actcaataac aggaactatc
    47281 acattatcaa ataccactat tgctgcatgt ggattaccag aaagaccaaa taatagcttt
    47341 tctcccaatg tacctacata acaagctcca ccaggtttaa tgtttatctt ccaaaataat
    47401 tctgttgccc ctattttttt gaatacatct ggaattaaat ctttatctcc aacagaaaca
    47461 ccacctgtgg taattaaaaa atctacactc tgtaacatat tctttacctt tttttctaac
    47521 tccaatatat catcagaaca attgcatatt gtatctgctt gtattccaag ttttaataat
    47581 cttgaatata aggtatatct attactatcg tatattttac cattctctaa agtctcattt
    47641 atatcttgta gttctgtacc tgtattcaaa attccaactt ttaaatcatc ataaacagtt
    47701 actttggata ttccaagact tgctaatact ccaataccat catatcctat attctgattt
    47761 ttattaataa tcaattgccc cttttttata tcctcaccct taaatatgta attatcgtat
    47821 tcctttaatt ttatatttaa agttatcata tcacctataa ctgttacatc ttcttttttt
    47881 attacacaat ttgcaccctg tggtatcttt ccaccagtca ttatcttcac tgcttcattt
    47941 ttatttaata ccctattaaa tacatctcct gcatacaaag tccctataac ctttaaattt
    48001 ctattttcag aatttgcatt atatgcataa ccatcatagg gtgacctatc aaatggagga
    48061 ctatcaattg ttgaatatat atcttctgca actaccttat ttactgcatc tataagattt
    48121 actatcttga ccctgtttat tggtaaaaca tttttttcaa taatttttat ggcatcttct
    48181 aattctatca ttttaaatac tccccaatat attttttatt taagatattt ctatgtaata
    48241 tattatagat tataaaagtt ggaaatactt ttatcttata tttaattata actaatagtt
    48301 atctataagt gcagttcaaa ttttataaat ctaataaaaa aactgttccc agctagaaat
    48361 ttccttctat cttgaaacag catcatatgc tttagaatat tttattctaa taaagttcct
    48421 tttattattt ttacaatttt atcactttca atagttttta tagattttat tttgttatcc
    48481 acaatactta ttgtaagtac ctcttttttt aatattttgt tatcttcttt caatctataa
    48541 ctcttaacta ctttactgcc ttcatgatta tatgctgtta aatcataatt cgcatctcct
    48601 acaatttcat ttattctgga atcttcaaca ccaacatact ctcccaggtc aatatgtcta
    48661 aaattttcta gtgatacagc cgatttttca tggtcacttt tttcaatcac tatactagat
    48721 tcagcatcaa tgactgatat accttgtgat gagaaagaat tggtttcaac attgacaact
    48781 ttattttcgt taatatcaac atataaagca cttccatcta gttcatcatt tccagtatat
    48841 tttggataaa ctaatgtcat ataacttgat gtatttatat cttgcattgt atttgattct
    48901 tttaaaactt taggttttat ataataaaat gtattataag gtatacccat attctttata
    48961 atgtacttat aatctttatt cataatttca ttaacatcat tttgaacttt tgtcatagtt
    49021 ttttgctgtg ttgctttact tgctacttga tttttctctt tagtattttc tttatgacat
    49081 ccaacaagta taatacctaa aatagttaca caaactaatg acctttttaa cttcataaat
    49141 caatcctcct ttcttaaatt ttatagtatt tatctatatc tcaatttaca gttatctctt
    49201 ttttcaataa ttatatttat tatattataa aataattata taatatttat ttgaatttaa
    49261 taagattaag aagctaattg taatttttct gtaataaaaa acactttaaa gttgaatttt
    49321 gaaaattcaa tttacgatat ttttattgta agtaccttac aacattatac caaattattc
    49381 ctaaacaatc aaaaactcca tgaatattta aaggttttct attttaaaaa tcacctttga
    49441 ctattaattt atcaaatatg ttataatagt tttagataat ttaaggagga ttaaataatg
    49501 gattttaaac aacttgaagt atttgttgct gttgcaaaac atcagagttt ttcaaaggct
    49561 gcaagagaac tttttttaac tcaacctact gtaagcgcac acatacagaa tttagagaga
    49621 gagctagaaa ctgttcttat aaatagaagc aacaaagtta ttacactcac aaaatctggt
    49681 gaaattcttt atgaacatgc tatatatata ttgaataatt gcaaacgtgc aatttatgat
    49741 ataaaagaat attcaggaaa aatagaaggt attatagata tagcatgtag ttccatacct
    49801 gaaacttata ttttacctga ttttatgaag agtttttcta tgagttatcc agatgtaaaa
    49861 ttttccataa gccattatga ttctcaatat gctatatcag aaattttaaa tgaacgaata
    49921 agctttggat tagttggttc taaaatcaat aatcctcaaa tagagtacct agacttatta
    49981 gatgatgaac ttgttcttat cactccttca gattttaaaa ttgataataa aaataattgt
    50041 atcgatatag gagaattggc ttatctaaat tttattatga gaaaagaagg gtcaggtaca
    50101 agaaacttaa tactaaacac acttagtaaa aataactttc cagtaagtaa attaaatgta
    50161 atcgctcatg tagaatcaaa tgaggctatt aaggaaatgg ttagattagg tcttggagtg
    50221 tcctttatat cgtacatttc agctatcgat tatctcaatg caggtaaaat aaaatgttat
    50281 aaaataaagg atgttgattt tactagaaag tttttcttca tttactctaa aaagaaaact
    50341 ttttccccat tagaagataa atttctaaac agattatgtg agtatttcga aattataata
    50401 taataacttt aataaagtag tgcttaattt tgagtttata actaattaat aagctaatta
    50461 taactatcac ataaatgctt ataaattatt atgaaccatc tttctttttt atttaattta
    50521 gtcaaaaaat ccctcgttca aatgaacttg ggattttttt atttatacta ctccaatagc
    50581 agccaatact atacaaataa tcataactga aattaatatc gtagttgtct ttaccttttt
    50641 tcctaataac caatacataa taccgaatat catagctgga agcatacatg gcattatttg
    50701 gtctaagtaa gtttgaatag gctctgccca ttctccacta cctacattaa cactaagttt
    50761 taacattaca ttagatgcag tcatacctcc aattaccata agccctaaca ttgaagctgc
    50821 ttccataact tttgaaacta tacttgaacc actcacatct ttaaagaatt gagttccata
    50881 cttaaatcct ttatctagac atatatagcg tataataaaa tgaggaacat ttattattaa
    50941 aaggaataaa atcggtccca ttatgttacc ctgagaagct aaagctatac caaccccagc
    51001 tgctataagc tttaatgttc cccagaaaaa tgaatctcct atcccagaaa ctggacccat
    51061 taaacttgat ttaacagcat ttatactatt agcatcaaat tctttattct ttgcattttc
    51121 ttcttccata gctccagata tacctaccaa aagagtactt atatgaggag taactgacat
    51181 aaattctaaa tgtcttttta aagccttaga tttcttttct ttatcatctt tatataatct
    51241 acggattatt ggtgccatca tgtatgcata tgctatattt tgcatacgtt cgtagttcca
    51301 agatgaatct aatgtcaatg accttctaaa acatttccaa aagtctttcc tcgttatttt
    51361 actatctggt gaaattgtct ctaacttctt agaactcgtt gtcatctact attacctcct
    51421 tctctcctac aaagttaaca tatattaaag ctattgctaa tccaaacaat gcaactcctg
    51481 ttactgttat gtttaggtaa gcaaccaata taaatcctaa taataaaaat gctactgttt
    51541 tcttattaag catcattcta gctaacatgg caaaacctat tgctggaatc acgcctgctg
    51601 caacatccat tccatgagtt acatatgatg gtataaatga aagtattttt tctattactg
    51661 gaacacctaa tgaaaatcct atacctacta ttattgctaa tattaattta tttcctatac
    51721 caaataataa ttgcacacgt tctacgcctt caatattccc ctcttctgca taacggtcag
    51781 caatatgagc tccccatgta agtactactg tcattaagaa gttatctata agcaatacta
    51841 gagttgctat aggaactgca agtacaactg ctgctgatac atcttgaccc gttaatatta
    51901 caaacgctgt ggcaataata gaaccagaca caaaatcagg aggattactt gccccaacag
    51961 gaaatgcacc cataaatact aattctaatg ttgaacctat tactatacct gtatgaagat
    52021 tacctagtgc taaaccaaca agtggtgcaa caactatagg tctattatgc attgtagaac
    52081 ctacaaaact atgcatatat gcaaagaatg caattagagt tatcaaaata acttgtgtaa
    52141 attccatttt catcccccta aaattatatt aatttcatta catttgtagc atcatcatca
    52201 ggaactaatt gtacaaatac atttacgcct tctgaatcta actctttaat catctttata
    52261 tcatcttttg atacatgcac tgctttagat atattttcac gattatcatc tgattttgtt
    52321 ccaccaaggt ttatagattt aatagctttt acctctttag caagtctata aacatcttct
    52381 acagattcac aaagtatcaa taagttgtat ttatcagtaa cacctgagtt aagtgctttt
    52441 atagaatctg ctatgctttt cattactaac ttaacattag atggtttagc cattttaagt
    52501 cctgccattc tcaattcatc ttttaataag tcatcacttg ctatcaatat acagtctgtg
    52561 cttaaaaact ttgtccatgt aaatgctact tgtccatgta taagtctgtg gtctactctt
    52621 actaatttaa tcattataat tcctccctaa tttttttgat ttcatccatg aatgttttta
    52681 cgtgttctac actaacatcc ccaaaatctt tgtaattatc tttaaagtaa cttcctatta
    52741 ttgccatatc tcctaattta agctgttttt ttgcattttc taatgtaact ccagcagcta
    52801 taaccaatgg gaagtctcct aaatttttac gaaacagttc tattttttcc attgatgttt
    52861 cttgacctgt agcattttct gtaactgcta tagcatcaca tcttgtcatt cctattttta
    52921 aatcttcttc aacatcattt tctgataata ctggctgata tttaaaacgt acgcctccaa
    52981 ttaaatacgc tgggcatttt gaacgttgta atttaaaaaa ctcttctaaa gtagcttcat
    53041 ctctaggttt aacatgacct actacagaat caacctgtat ataactagca ttatattttg
    53101 ttgccagttc aaatcccata gtatcaacat ttaaacagtt tactccatat ggtattgata
    53161 aattagcttt tgatacatat tcaagtattc tttctaaatc ataataatta ccatagtaat
    53221 tttctaacat tattccatct acaccatttt cttcaaagat tgtaatctct tttttagctc
    53281 tttcaaagat atcttctgga gtatctcctt ttaagtgtat cattgctata attggttttt
    53341 tacttttaaa tactgataat attccctttt ttttcataaa ctaaaatacc tcttcttctt
    53401 ctttaatttg taatgtcacg ctttgtattc ctcttctaga ttcttccact aattggtcta
    53461 tatcttcaac ggttaattca tcagaaaacc ttgtaagaag ttctaatacc atattcaaat
    53521 tcattccaga aaataaccta acattatgta gattagttaa tcttaacatt gctgtacata
    53581 cacttgctcc atataagtca gataaaatta tatattcaca ttctttatct tctgatattg
    53641 ttttttctaa ttctaaagca aaatctgaag cactttgtcc agggtacaaa ccatacgaac
    53701 tgacacaatc tgctaaatct cctactatca tttttactgc atttaaaagc ccttttgaaa
    53761 agtctccatg agatgctaat attatctttt tcatactcat cctcctacta aattatagat
    53821 tatatttctg ctgatactgc atatttgtac ttatcacttc ttataaattg ctcattgtaa
    53881 tataagacat cattattttc tgtatacacc gattgtctta ctttcaatag tggcatatta
    53941 cttgcacatt taagatggtc agaatattct ttgtttgaat gttttacttc aaatatattt
    54001 tctactcgtt taggtaatgt gcttatatta ttagatataa cctccattaa agatttatct
    54061 tctaattctt cttttaataa aaacatgtaa tctattctaa aatagtcaac ttcaaaaata
    54121 acaggtactt catctattaa tctaagtctt ttaatacata ttaccttctc ttctagttca
    54181 atacttaaag cttcagctac ttgcttatct gcttttttta ttaaaacaga gattattttg
    54241 gtacttggtt ttgcattaat acgatgacaa gaattagtaa aactatttcc tgcacatgtt
    54301 gcttctattc tctctggtat tgttacataa gtccctttac cacgtttttt acataatata
    54361 tcttctttta caagttcatt aagtgcattt ctcacagaaa ttcttatatt ttatttatgt
    54421 ttatttatat ttatttatgt ttttatgagt acatttattt acaacctatc taaaacaatt
    54481 tctttattct attttattta tatttcttta tttgtatttt attttattaa actgtcatgg
    54541 tggcaaaaaa ggtggcaaaa ataatttgcc acctaaaata atctttattt attctttctc
    54601 ttttaaattt ttaaaatgtt cttcgagttc aattaattta tcttcatcca cttcatcatc
    54661 tttactatgt aacgctgata ttaaacttga aattgaattc ttatgtatgt tcttcaaaaa
    54721 ttctttcgtt tcaaacctta gatatttttt ctcttttact agtatattgt aatgtgtaag
    54781 tttgcctatt ttctctgtgc ttaaaaattc tcttcgctct aaccttttta aaactgtaaa
    54841 tgtcgttgat tcattccatt catatttttc ttccattgca gcaactaatt ccctagaagt
    54901 taataccttg ttagcttccc aaatatatct cataactttt aattccgctt ctggtaattt
    54961 actaattttc atagtctaca cccctttacc gatttatgta tatgttaaat tctatatcaa
    55021 taaagtttta caaacaagag aattaaggta aataattcca tccaattttt accatatcat
    55081 tcttttaagt ttttatagta ctcttctaat gagtctaact tctctttact tacattttta
    55141 tgcgtagtgg taagtgaacg cattattttt ctacttttac tagattttag tacctttttc
    55201 ttaaaagcat aatattcttc attatctatt attattttat aataagattg aaattttata
    55261 atatccctag ccaaataacc tttgtcaatt agccttttta gtagtatttt tattgtactt
    55321 ttatgccatc cataaatctg ttttatttct tttacaattt cttttttagg cattagagtg
    55381 tcctttttcc ataaatactc cattactatt aattctgctc ttaataattt ttctattaat
    55441 atttcttctt tcaatttatg tcacttcctt aaattcgtct aacttaaatt aataatagga
    55501 gctttttaag acaaaaacta gaggtaagtt ttaccaaata ttctacatat ttagtctgtt
    55561 tttttaagtg taaaataatg ttcatatcta taaatttat
//
LOCUS       DAEPID010000018        55071 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.018, whole genome shotgun sequence.
ACCESSION   DAEPID010000018 DAEPID010000000
VERSION     DAEPID010000018.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 55071)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 55071)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..55071
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.018"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            complement(<1..896)
                     /locus_tag="KR257_001232"
     CDS             complement(<1..896)
                     /locus_tag="KR257_001232"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009243519.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="lysozyme family protein"
                     /protein_id="HBH0029949.1"
                     /translation="MKLKHIALIGSLFPILFSLVLFFGVLISADSDDENSNFSSGITG
                     MNLSAEVLKHQPMVEKYARENGISEYVNVLLAIIQVESGGTAEDVMQSSESLGLPPNS
                     LDTESSIKQGCKYFASLLSSCKNQGIDDLNVAIQSYNYGGGYVGYVAGKEKKHTFNLA
                     ESFAREKSGGKKVTYTNPIAVAKNGGWRYGYGNMFYVELVNQYLTVAHFDNATAQAIM
                     NEALKYQGWKYVYGGSNPNTSFDCSGLVQWCYGKAGISLPRTAQAQYDATQHLPLSQA
                     KAGDLVFFHSTYNAGSYVTHVG"
     gene            complement(893..2966)
                     /locus_tag="KR257_001233"
                     /pseudo
     CDS             complement(893..2966)
                     /locus_tag="KR257_001233"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002323347.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="YtxH domain-containing protein"
     gene            complement(2966..5416)
                     /locus_tag="KR257_001234"
     CDS             complement(2966..5416)
                     /locus_tag="KR257_001234"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898619.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding protein"
                     /protein_id="HBH0029950.1"
                     /translation="MFPIKYIDNNLVWNKDNEVFAYYELIPYNYSFLSAEQKFIVHDS
                     FRQLIAQSREGKIHALQIATESSIRSMQEQSKKLVTGKLKEVAYQKIDEQTEALVSMI
                     GDNQVDYRFFLGFKLMVTEEQLNLKNIKKSAWLTFTEFLHEVNHTLMNDFVSMPNDEI
                     NRYMKMEKLLENKISRRFKVRRLEINDFGYLMEHLYGRDGIAYEDYEYQLPKKKLNKE
                     TLIKYYDLIRPTRCVIEESQRYLRLEHEDKESYVSYFTVNAIVGELDFPSSEIFYFQQ
                     QQFTFPVDTSMNVEIVENRKALTTVRNKKKELKDLDNHAYQAGSETSSNVVDALDSVD
                     ELETDLDQSKESMYKLSYVIRVSAPDLDELKRRCDEVKDFYDDLNVKLVRPAGDMLGL
                     HSEFLPASKRYINDYVQYVKSDFLAGLGFGATQQLGETTGIYMGYSVDTGRNVYLQPS
                     LASQGVKGTVTNALASAFVGSLGGGKSFCNNLLVYYAVLFGGQAVILDPKSERGNWKE
                     TLPEIAREINIVNLTSDKDNAGLLDPFVIMKDKEDGATLAKEILTFLTGISTRDGDKF
                     PVLISAISKVSESEHRGLLNVITELRQENTPIANHIANHIASFTNYDFAHLLFSDGTV
                     ENTISLDNQLNIIQVADLVLPDKDTTFNEYTTIELLSVAMLIVISTFALDFIHSDRSI
                     FKIVDLDEAWAFLNVAQGETLSNKLVRAGRAMQAGVYFVTQSSGDVSKESLKNNIGLK
                     FAFRSTDINEIKQTLEFFGIDKDDENNQKRLRDLENGQCLLQDLYGRVGVVQIHPVFE
                     ELLHAFDTRPPVQRNEVE"
     gene            complement(5394..5792)
                     /locus_tag="KR257_001235"
     CDS             complement(5394..5792)
                     /locus_tag="KR257_001235"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009274602.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="conjugal transfer protein"
                     /protein_id="HBH0029951.1"
                     /translation="MKKIKSYTGIWNVEKVLYAINDFNLPFPVTFTQITWFVITEFII
                     ILFGDIPPLSMIEGAFLKYFGIPVALTWFMSQKTFDGKKPYSFLKSQITYALRPKITY
                     AGKAVKLHKQTLNETITAVRSVNYVPDKIY"
     gene            complement(5909..6412)
                     /locus_tag="KR257_001236"
     CDS             complement(5909..6412)
                     /locus_tag="KR257_001236"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004843360.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="antirestriction protein ArdA"
                     /protein_id="HBH0029952.1"
                     /translation="MIDDMAVYIANLGKYNEGYLVGAWFTFPIDEEDVKEKIGLNEQY
                     EEYAIHDTDNFPIAIGEYVSIEELNEMYEMIEELPDYIVECLDEFISHFGTLEEVVEH
                     KDDIYYYPDCETMTDVAYYYIDELQALGDIPPSLQNYIDYEAYGRDLDMGGCFIETSR
                     GMCEIPY"
     gene            complement(6430..6933)
                     /locus_tag="KR257_001237"
     CDS             complement(6430..6933)
                     /locus_tag="KR257_001237"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004843359.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="antirestriction protein ArdA"
                     /protein_id="HBH0029953.1"
                     /translation="MQETRVLVETRGTTGEETISYWFELPIDVAEFEEKLGVGAESGD
                     YRIIEKVLPYADEVHEHTSVYQLNELDFMYRQLSSDMQEEYVSLLTVFENLEALYICR
                     NVITVYPDCKSMIDVARQKLMNDPTFKHLSEDCQEYYFDFEAYASHLQEHGKFLVTEH
                     GIFELPE"
     gene            complement(6852..7148)
                     /locus_tag="KR257_001238"
     CDS             complement(6852..7148)
                     /locus_tag="KR257_001238"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005339688.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="conjugal transfer protein"
                     /protein_id="HBH0029954.1"
                     /translation="MNDIFKDMQSKVGCDYISDLPSYKRKVWHEMKRLNLADYEERQL
                     EDFSKYVFGMSYQTLKDVMKQQKGREEQCRKQGCWWKREEQLAKKQYHTGLNCR"
     gene            complement(7237..7863)
                     /locus_tag="KR257_001239"
     CDS             complement(7237..7863)
                     /locus_tag="KR257_001239"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009319953.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha/beta hydrolase"
                     /protein_id="HBH0029955.1"
                     /translation="MKYIMLHGLGQSSESWSDTVKVFNDDFEVLCPNLSDWLSGKTPC
                     YDTLYRTLETYCEQFEEPLNICGLSLGGILAMQYAIEHPEKVNSLVLIGTQYEMPKYL
                     LKMQNLIFRIMPCSAFEKMGFRKTDFINLCKSMMELNFKHELKKISCSVLVVCGDKDK
                     INKKASLELQQQIENAEIAIIENAGHEVNTDNPTLLGQKLNVFFKQYV"
     gene            complement(7934..8155)
                     /locus_tag="KR257_001240"
     CDS             complement(7934..8155)
                     /locus_tag="KR257_001240"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002570387.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0029956.1"
                     /translation="MNFGQNLYQWFLSNAQSLVLMAIVVIGIYLGFKREFSKLIGFLV
                     VALIAVGLVFNAGGVKDVLLELFNKIIGA"
     gene            complement(8156..8290)
                     /locus_tag="KR257_001241"
     CDS             complement(8156..8290)
                     /locus_tag="KR257_001241"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017143882.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3789 domain-containing protein"
                     /protein_id="HBH0029957.1"
                     /translation="MWVLLKDFLLVSMGMGIGVVLMCILNVGKEADYKMKQLEESEDN
                     "
     gene            complement(8303..9499)
                     /locus_tag="KR257_001242"
     CDS             complement(8303..9499)
                     /locus_tag="KR257_001242"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003062030.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="XRE family transcriptional regulator"
                     /protein_id="HBH0029958.1"
                     /translation="MVLNEEQWIKELREKRIAYGISQGRLALASGITREYLNKIESGK
                     MKPSKELLNILHEELARFNPEAPLTMLFDYVKIRFSTLDIQHIIKDILKLNINYMLHE
                     DYGHYSYTEHYSLGDIFIYTSSDEEKGVLLELKGRGCRQFESYLLAQQRSWYDFLMDA
                     LIDGGVMKRIDLAINDHTGILDIPELAEKCRKREYIGKSRSYKFYQSGELIKHREDDR
                     EYMGRTLYLGSLKSDVYFCIYEKDYEQYVKLGTPLEEADIINRFEIRLRNERAYYAVR
                     DLLTYYDAEQTAFSIINQYVRFVDEEPDKRKNDWKLNDRWAWFIGDNRQSLKLTTKPE
                     PYTLDRTLRWVQRQVAPTLKMLKKIDKGNGTDYMDTIEQQAKLTEKHEMIIKQQTTPA
                     KDLVES"
     gene            complement(9744..10160)
                     /locus_tag="KR257_001243"
     CDS             complement(9744..10160)
                     /locus_tag="KR257_001243"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009290089.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0029959.1"
                     /translation="MEIKEINKIIQSEDKDEKVKSVKCICINYGDFLADCEGFVQKRY
                     HDFKCNPKHQFEKKADTILENAIHEKNFMPDLFLIRLNRKQSACNSQIDFVFELLDKS
                     FLETDPIRKSEISEETLNLCLSADVSFIMVYIGMNR"
     gene            complement(10164..11546)
                     /locus_tag="KR257_001244"
     CDS             complement(10164..11546)
                     /locus_tag="KR257_001244"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009290090.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding protein"
                     /protein_id="HBH0029960.1"
                     /translation="MRKIFNKGHRIRASDKHLVYHYCIGTLLFVFMAVLLLLNSKQLM
                     RTNWEHFSLLQNGLILSPYNFITILIATGVCVLVAFLYYRFCYDSFKKLLHRQKLARM
                     ILENKWYEADTVQDSGFFTDLQSRSREKIVWFPKIYYQMEKGLLHICCEITLGKYQDQ
                     LLRLEDKFESGLYCELTDKTLHDGYIEYTLLYDMIANRITIDEVRAENGCLRLMKNLV
                     WEYDALPHALIAGGTGGGKTYFLLTLIEALLHTNAVLYILDPKNSDLADLGTVMGNVY
                     HTKEEMIDCVNAFYEGMVQRSEEMKRHPNYKTGENYAYLGLPPCFLIFDEYVAFFEML
                     GTKESVGLLSQLKKIVMLGRQAGYFLIVACQRPDAKYFSDGIRDNFNFRVGLGRISEL
                     GYGMLFGSDVKKQFFQKRIKGRGYCDVGTSVISEFYTPLVPKGHDFLQTIGRLAQERQ
                     VMPEQQGKEN"
     gene            complement(11616..12407)
                     /locus_tag="KR257_001245"
     CDS             complement(11616..12407)
                     /locus_tag="KR257_001245"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006573936.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HBH0029961.1"
                     /translation="MTLGEKIQKLRKQNGFSQEELAEKVTVTRQTISKWELNQSEPDL
                     DFIAQLSNIFNVSADYLIKEELTKPDELPFRKKRYQYYFSERSKRTMFVAISIVALIA
                     SIVCLICDYFTSDKLSWSFIAIEAIIAVWLVFLPCMLFKEKVIFKTLIICSIIPIPFL
                     AILALLLKVTTIFTLGSCISVLCIAIMWAIYGIFRKYHQRIFLSLGFSLLLLIFVPIV
                     IVRVTDYFLPQYEIVSKSDVFNGIITFAIALICFGIDYLTQHKNK"
     gene            complement(12551..13189)
                     /locus_tag="KR257_001246"
     CDS             complement(12551..13189)
                     /locus_tag="KR257_001246"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016280180.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha/beta hydrolase"
                     /protein_id="HBH0029962.1"
                     /translation="MKYIFLHGLGQTSFSWNKTLEVMSDKWDILCPNLADWLYNERPC
                     YETLYKALERCCKQFNEPLTLCGLSLGGILAMQYSIEHSEKVHSLVLIGTQYAMPKKL
                     LKMQNIMFQFMPSSMFSKMGFQKADFISLCKSMIDLDFTHNLKDISCRVLVICGEKDK
                     PNKSASLQLGNLIPYAKITIISGAGHEVNIDAPIKLGNELNVFFNSSHNTER"
     gene            complement(13273..13656)
                     /locus_tag="KR257_001247"
     CDS             complement(13273..13656)
                     /locus_tag="KR257_001247"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009588269.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YdcP family protein"
                     /protein_id="HBH0029963.1"
                     /translation="MRLSNGFVIDREKTFGELKFTAVRDVFLQNEDGTPSTQLKKRIY
                     DLKCSLHGGIIPVSVPPEVPLREFPYNAVVELVNPVADTVSRKTYTGADVDWYVKAED
                     IVLKNKGNQNAGSPQNNNSQGQQKK"
     gene            complement(13672..13998)
                     /locus_tag="KR257_001248"
     CDS             complement(13672..13998)
                     /locus_tag="KR257_001248"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003417601.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YdcP family protein"
                     /protein_id="HBH0029964.1"
                     /translation="MEMKYVVPDMAQSFGTLEFAGESEPVFERDKNNRRVLARRSYNL
                     YSDVQKGENVVVEIPVQAGEKKFKYEQKVKLVNPKLYGRGYAIGDMGHTDYVLVADDI
                     VAVEEK"
     gene            complement(14233..17277)
                     /locus_tag="KR257_001249"
     CDS             complement(14233..17277)
                     /locus_tag="KR257_001249"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861958.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SrtB-anchored collagen-binding adhesin"
                     /protein_id="HBH0029965.1"
                     /translation="MKKMLKRLCTGFLALATVVTALPTTPVHAESKQYWTESKERVGI
                     VEKVMNDGSIGSTFNEGHLTVEGEDAYCIDINTDFKNGYKIRTDASTRMSADQISDVA
                     LSIEYVKQYTDSHSGISNNHAYLLRQLVVWQRLSVHLGWQCDNVRASYDEIPKATQDE
                     VFAGARAFVKENKGRYECGGYIYSGEGQELGQFWAKLNVGNAKLQKTSNNTSITDGNG
                     NYSIAGATYGVFSDKDCTKQLATLTTDENGNTDVVEVKAGTVYIKELSAPAGYKVDKT
                     VYPLTIKAGETATLNVSDTPKVTDTLIELFKIDMETQKDNPQGNASLAGAEFTWKYYA
                     GFYNKDNLPAEATRTWVTKTVAETDSDGATHYITKLADAYKVSGDSFYMQGVKAVLPL
                     GTLTVEETKAPNGYLLDGAYMQAGDKSEQIKGLYVTQITEDGDLAVLSGSNQFSVSDK
                     VIRGGVKIQKRDLETGDTKPQGSATLKDTAFDIISLNDNAVLVEGKLYKKNEVVKTIR
                     TDIEGVASTSADLLPYGKFRIIESEAPDGYLTDGAKPIDFAITENGKIVDLTDEAHSI
                     YNQIKRGDIEGVKIGAGTHKRLADVPFRITSKTTGESHVVVTDDNGQFSTSADWASHK
                     HNTNAGKTSEDGVWFGTSEPDDSKGALPYDTYIIEELRSDSNKGFELIPPFEIVVSRN
                     NLVIDLGTLTDEYEKEISIHTTATSKDGEKTILAGKEVTIVDTVKLDGLEKGTKYQLK
                     GWQMLKEENAELIIDGKRVENDYTFVADEEEMKVEISYTFNASALGGKNLVTFEELYD
                     LSNPDEPVKVAEHKDIEDDGQTVLITERIIKIHTTATDKDGNKELEAGKDVTIIDTVT
                     LEGLEVGTQYKLVGWQMLKEENIELLINGKRVESDYTFTADSETMKVEVVFTFDATSL
                     DGKQLVTFEELYDLSNPDEPKKVTEHKDIEDKGQTITFKEKPEEPEKPETPPTPEKPS
                     RPSDSPKTGDSTNVMAFVVMLLASAGGLAGIFFYKRRKMKNS"
     gene            complement(17653..18861)
                     /locus_tag="KR257_001250"
     CDS             complement(17653..18861)
                     /locus_tag="KR257_001250"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893711.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dicarboxylate/amino acid:cation symporter"
                     /protein_id="HBH0029966.1"
                     /translation="MKKKIGLVPKLIIGIIVGILIGSYAPEIIVQILVTVSTLFSAFL
                     KFVIPFIIIGFVTAGIADLATGAGKLLGITTGIAYGSTLIAGLLSFAVSTLIFPNFID
                     ASVASQIGDPEAGMLAPIFTIPLEPMVDVTAAIVFAFVMGLGISALRNHGKGETLFNF
                     FQEFQGIVTKTLSTVIIPLLPLYIAGTFANITIAGEVWTILGVFWKVYLVVIPLHFVY
                     MACQFTAAGVFSGKNPVRMLKNQVPGYLTAIGTQSSAATIPVNVGCAEKNGVSKQIRE
                     FVVPLCATIHLSGSMISITGFTTAVLMMNGMPHGIGVLFPYIAMLGIAMVAAPGAPGG
                     AIMSALPFLPMVGIPSDGGLASLMIALYLTQDSFGTACNVSGDNAIAVVVDKINDGMS
                     KKGNKEEQSA"
     gene            complement(19022..19411)
                     /locus_tag="KR257_001251"
     CDS             complement(19022..19411)
                     /locus_tag="KR257_001251"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004455003.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1232 domain-containing protein"
                     /protein_id="HBH0029967.1"
                     /translation="MEFLKIIINIVLDILKKILVRFKNAKFGLVFVFDLLKLPDFMTD
                     KRINIVDKIKVISVLIFTISYFVSGVDIIPEMIAGAFGFIDDAIVLIWSIGIVNEEIN
                     KYRVIAKKDKHSNIIENVEFSIKDEEE"
     gene            complement(19515..20516)
                     /locus_tag="KR257_001252"
     CDS             complement(19515..20516)
                     /locus_tag="KR257_001252"
                     /EC_number="6.3.1.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003427105.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aspartate--ammonia ligase"
                     /protein_id="HBH0029968.1"
                     /translation="MSTIIPKDYKSSLNVIDTQIAIKKLKDFFEMRLSNELNLIRVSS
                     PLFVLPETGANDNLNGEKAVSFDIPFMNKNAEIVQSLAKWKRLALKKYGFEVGSGLYT
                     DMNAIRKNEELDNIHSLYVDQWDWELVIDKSSRNEKTLKDVVKRLYGVFKDTEIFVCS
                     MYEGIKEILPEEITFITSQELEDMYPELSPKEREDKIVKEKKAVFITQIGKTLISGEK
                     HDGRSPDYDDWELNGDILFYNPVLDSALELSSMGIRVDEESLDRQLKLAGCEERKEFD
                     YHKMLLNGELPYTIGGGIGQSRICMYFLQKAHIGEVQVGVWPQDMIQNCSSAGIELL"
     misc_binding    complement(20575..20830)
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00230"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="T-box leader; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /bound_moiety="tRNA"
                     /db_xref="RFAM:RF00230"
     gene            complement(20964..22154)
                     /locus_tag="KR257_001253"
     CDS             complement(20964..22154)
                     /locus_tag="KR257_001253"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728658.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pyridoxal phosphate-dependent aminotransferase"
                     /protein_id="HBH0029969.1"
                     /translation="MSKYNFDRVIDRVGTDCVKWDFRTNCSTKAQKDGLPFWIADMDF
                     ECAEPIIEALRKKVEHKIFGYSSNDSDKYFNAVCDWYKRRFNWEINRKDIIFSPGVVP
                     AVAILVRILTNSNEGVIVQKPVYYPFEAKIKSNNRDVVNNPLIYENGTYRMDYDDLEE
                     KAKCSNNKVLILCSPHNPVGRVWREDELKKVVEICKKYDLWIIADEIHSDLIRKGFKH
                     TPLQSLCPEYKDKIVTCIAPSKTFNLAGMQLSNIIVNNDELKKKYQEEVTAVGVATSP
                     NPFAIVATIAAYNESEDWLNELNDYLDNNIQFIDEYLKENLPKVKLVYPEGTYLAWLD
                     FTAYGLNEVELEDLMFKKANVLFDEGYIFGKEGIGFERINVACPQSLLKECMDRLKTI
                     FENL"
     gene            complement(22435..23556)
                     /locus_tag="KR257_001254"
     CDS             complement(22435..23556)
                     /locus_tag="KR257_001254"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890931.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="M20 peptidase aminoacylase family protein"
                     /protein_id="HBH0029970.1"
                     /translation="METNKDYIEYVHKVYDYLHTIPEKGFEEYKTSEFVLKELEKMGF
                     ENINKGIAGTGIIVTIDSKKEGPVFAIRADMDALEFIIDGEKKMIHACGHDGHTSMLL
                     TAAKLIKERNLVKRGKLKILFQPGEEKLYGALRVIDSGLLDDVEEMVGMHLRPGQDCR
                     LGKAIPAMYHCASCIMEFTIKGITCHGSKPHLGVNAVDAVCLAVNAINAIRVNPAIPN
                     SIKVTNISVKGETYNNIPDEAFMALDIRAESNDIIEELKEKAIHAVKTAVSSINAEAV
                     LISKDGVPAAEFDEELVNLAEETIKDVLGADASIGIFKNSGGEDFHYYTQKLKCKTTY
                     IGLGADATPGFHNPNVTFDTKALEYGVDIWCRLVEKRLG"
     gene            complement(23617..24102)
                     /locus_tag="KR257_001255"
     CDS             complement(23617..24102)
                     /locus_tag="KR257_001255"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004455006.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YjiG family protein"
                     /protein_id="HBH0029971.1"
                     /translation="MSEVAKKEVKVKKGNVIDAFIGGARNGFQISTNSMAPNVIFGFA
                     IISVFNLTGLLDVIGTIFTPVMSIFGLPGVAATAIMTIFISMGGASGVIAGLFTAGQI
                     SQAHVAILLPMLLLSGAQIQFMGRLLGTAELKTKYYPHMFVIATLNGCIAMLIMNYFV
                     V"
     gene            complement(24104..24772)
                     /locus_tag="KR257_001256"
     CDS             complement(24104..24772)
                     /locus_tag="KR257_001256"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890933.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0029972.1"
                     /translation="MSKLESTTEKVEVKWYGYVALILGALFFSGIFKDAPGPLKVLDF
                     NNVLGSFGTLGTINDGVGTLAANFRGDGGTGPRDGWLYALTLIPSVMFALGVVRVIDH
                     LDGMKAAQKLLSPLLKPLLGLPGFAGLTLIASLQSTDAAASMTKELKDDGYIDEKQKA
                     VFCAFQFSGASAITNFFASGAALFPFIGDVPIFIPLALILIMKFVGANLLRLYLNKFD
                     KGEA"
     gene            25162..27186
                     /locus_tag="KR257_001257"
     CDS             25162..27186
                     /locus_tag="KR257_001257"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009899983.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sigma 54-interacting transcriptional regulator"
                     /protein_id="HBH0029973.1"
                     /translation="MDKKKLILITHDKLNSDHYKEELTNFFGDEIIIETQNILDGIKE
                     NLEGDVVLSLSPLTSNFLIKHFKEDIEIIHGTKALSKLGYEKMMKLPPGTKSLLMTTN
                     KTSAFEMATYLYKIGINHIDFVPTYPDCDEIYDLDTAITPGQIRFIPKYIKNIVDLGW
                     RKISLDTYMSLLVVLKLKNEKFIEKLYKLSKETLSHDFLNTSLDNISKLKTILYMTID
                     EIGDGLIFFNTFNKVTFVNKSLLNMLGLDEKLIKSPSLMEYMPNSFLDKITKNLNIDN
                     MIIYIDEIDKKFILSKKPFYLYKNIEGCLITLKDVNNIEILEQKIRSDSVKRGYVAKY
                     KFNNIIGNSSIIKDCIKKAKKMALTDNPILITGETGTGKEAFTQSIHNHSNRKNKPFV
                     AINCASLPSELLESELFGYEDGSFTGAKKGGKKGLFELAHTGTIFLDEIGDMPHDLQV
                     KLLRVLQEKEIRKIGGTSIIPIDVRILAATNKDLEKLIIENKFRMDLFYRISMFTLDL
                     PPLRKRLEDIPLLLESFLKELPYKNIKLDKSLLEALNSYTWMGNIRELRNCIEYMAYM
                     GSNYLTINDLPQNISSKLNNNHMSSNMSIFNDLNQYDKNICISILKSLHMKPMGRTKL
                     MKFMEYNVTEYEVRNMLEYLTRNGYLISSKGRKGSSITEKGIKIIENNII"
     gene            complement(27416..28603)
                     /locus_tag="KR257_001258"
     CDS             complement(27416..28603)
                     /locus_tag="KR257_001258"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861650.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3798 domain-containing protein"
                     /protein_id="HBH0029974.1"
                     /translation="MLRKITAFMLSICLIIGLTGCSLLVGKKDKEKIIDDFKVAVVTQ
                     PLSENKVQYNMVEEMAKEYEEENKIDKDKDGQTKVKQTIKHVVLPENFTSNIDSAINK
                     IVKLADDKEVQAIVVSTDQAGLLPALQKVKEKRPEIITISAPMGDDKNQLSQFVDVNL
                     GVSAEERGKVLAERSKEMGAKAFIHYASTDDLKDVNIAKRLEMIKETCKNIGLPFVQV
                     NTPNINTEEDKNKVKQFLNEDIEKQVKKYGKDINVFGVNEYMDEVILTKALELKYIVA
                     EQSNPSPIQTYPSVMGLKISEKDAQNYDKINDMISEKAKAFGMSNRLGGYPMPMDAFL
                     PSVAIYLATEMVKQDLTQEDVCDPDYLEAFTELRFGIGSEFTPLTEVLYNYQSVILSQ
                     LIY"
     gene            complement(28805..30076)
                     /gene="brnQ"
                     /locus_tag="KR257_001259"
     CDS             complement(28805..30076)
                     /gene="brnQ"
                     /locus_tag="KR257_001259"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004455013.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="branched-chain amino acid transport system II
                     carrier protein"
                     /protein_id="HBH0029975.1"
                     /translation="MRDIFIVGFALFSMFFGAGNLMFPPFLGMESGKDWLIPLIGFVV
                     ADAGIAMLVIIATARCKGSMDDVLRRAGKGLARVMSVAALACLALLVIPRTCATTYEM
                     GIMPIFGDHGPVAKAVFSIIFFGLTLAFTIRSSKVIDIIGKYLTPALLLVLFVLIVKG
                     IISPAGPMSPEHMIDKNLFGEGISQGYQTMDALGAASMATIMLMSIIAKGYTSDKDQI
                     GMTIKAGFVACVFLAVVYGGLTYLGATVSTLYDTSIPQASLLVEITSILLYGQVGKVI
                     LGVIVALACLTTSTGLTASISTYFEGISKASYKQLVIGICVASMLISNLGVDSIIAIS
                     VPILQTIYPVLLAIVVMELAGKHIKNDNAFKGAAYVTLVISLLSAINGMTGAVPFIQS
                     LPLAGLGFNWVIPAILGGIVGNFIKSNKQVA"
     gene            complement(30217..30870)
                     /locus_tag="KR257_001260"
     CDS             complement(30217..30870)
                     /locus_tag="KR257_001260"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893713.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pentapeptide repeat-containing protein"
                     /protein_id="HBH0029976.1"
                     /translation="MTKIIKVQKPKFTGELEIIENLEDILEDIFNDEKIFNKIIENEV
                     ISDLDSVRVSFESCIFRNVSFENCNLKKIDLLDVVFENCNLSNTFFDGGSIYRVEFKN
                     SKLIGVRFDDCILKNVLFKDVLGKYSNFSFSKFKIVSILDSNFENSVFQEVKGDNLVF
                     EYTNLKKANFNGTKLSGIDFTTNNIEGIEIGIDDIRGAIFDVSQAIDLTKLMGIIIK"
     regulatory      31199..31300
                     /regulatory_class="riboswitch"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00167"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="purine riboswitch; Derived by automated
                     computational analysis using gene prediction method:
                     cmsearch."
                     /bound_moiety="guanine and/or adenine"
                     /db_xref="RFAM:RF00167"
     gene            31373..32716
                     /locus_tag="KR257_001261"
     CDS             31373..32716
                     /locus_tag="KR257_001261"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421552.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NCS2 family permease"
                     /protein_id="HBH0029977.1"
                     /translation="MVPNTNNVQPGGNNSSLSFLDKMFKFSERGSSLKTEVIGGVTTF
                     LTMAYIVFVNPAILSEAGMDKAALITVTILATAIGTLIFAILGNAPFALAPGMGLNAF
                     FTYSLVIGAGIPWQTGLGVVFLSGCVFFTLAVTGLRKTIADAIPRELAVASSAGIGLF
                     LAFVGLKNMGVIIANPDTIVSLADFTPTVLIALFALILMAILEYKKVKGGILISIVVA
                     TIISVIFGFVELPTAIISTPPSIAPVAFKLDIVGALKFSLIGPIFSFMFIDMFDSLAF
                     LITCCKQMGLEDENGEIKDLGRMLYADVSSTLIGSFLGTSTVTTFGESASGIAAGART
                     GLASIVTAALFLATLIFTPLLGIVPTYAAAPALVMVGVFMFESIKQIDFADSKIAVPA
                     FVTVLLMPLTYSISIGLCFGFISYIIMHVVAKETDKISITLWIIGLLAVVNLVLS"
     gene            32895..34259
                     /locus_tag="KR257_001262"
     CDS             32895..34259
                     /locus_tag="KR257_001262"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897881.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amidohydrolase"
                     /protein_id="HBH0029978.1"
                     /translation="MSQLLIKNAYLITMNADREVYENGSILIENNIIKEVGKFDINIV
                     DKDAEIYDAKGKILMPGLVNTHVHLSQQLGRGLADDVVLLTWLRERIWPYESSFNYED
                     SLISSTACCVELIKSGVTTFLESGGQYVDAMVEAVDKTGLRACLAKSVMDTGDGLPEA
                     WQKTTDEEINTQLDLFHKFNNTSNERIKIWFALRTIFNTTEELLVRTKELADKYNTGI
                     HMHIAEIADEISFVKQNNGVGTVEYLDKLGVLGPNLLAAHTVWLTHKEIDLFRLHDVK
                     VSHDPGSAMKVVLGFASIPEMLEKGIPVSIGTDGAPSNNRMDLMRDMYLTSLIHKGRT
                     LNPTVVPAEEVLEMATINGAKCALLEKEIGSLEVGKKADMIILNPDTIHCLPMHNPIG
                     NIVYSMTSENVDSTICDGKWLMKERKVLVVDESELLNKVKKQASKIKDKAEVKIPSKF
                     KIIK"
     gene            complement(34437..36302)
                     /locus_tag="KR257_001263"
     CDS             complement(34437..36302)
                     /locus_tag="KR257_001263"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421550.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HIRAN domain-containing protein"
                     /protein_id="HBH0029979.1"
                     /translation="MENVFKRLQEFNGYDGYKESFEMNYLCIYESIPLREQVELANNL
                     VDEILNMYKSESNEIYLLEGSNSKSLICYFEIFMKKINTLVKEMIIDEKWLYKLTKEL
                     IYKSKKVEYVKLGLVLSEKYLNVENLREVVDTFSKSGEYVFYLSNTIKKLEFYNTYLF
                     NLSKKATGSIKVFAIVNMENLDSKINSYLIEDGYKDTKYERLLMNYIISIVDLNEYLE
                     KRDLDKEKINNLARLICNYLLSVEFKYIGNKLELVNRFLPTVVNYGTNFESLYSIFLI
                     AINVLKDENIECNKIEFEKEINGILLSEKWKNIYFEALRDASGKTEDIIKMSEIYDVN
                     LSFDDLLPYLNRDIRDFEVYWHISKKGTTSSRLKLLNFFEETFKIDDLIGKMKDIEKD
                     KLTQEYYDDMLFFIVLKGSKSLYPEGKNISLKGIFGNINEVRKESINILKRYREKLSL
                     EELKIVKEAYEKEKNVILKDELRRVLYESNNLKKEFVNIEKIKVDEHGKDIYLTSIAV
                     AGSRFRNREYLEKELEKSKIYYLTREKDNLYDEKAIKIVGETGYVIGYVPRKENYILS
                     NLLDGGKLLYCRVTEYNLYEDCIYANVYLSYKDVIETVENSLKMVLDKSRIKLIN"
     gene            complement(36538..37755)
                     /locus_tag="KR257_001264"
     CDS             complement(36538..37755)
                     /locus_tag="KR257_001264"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004455016.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MFS transporter"
                     /protein_id="HBH0029980.1"
                     /translation="MNNKKYYPTAIALYFSYFLLGIGISILGQYKPEFSSMWGAKTLS
                     DGTLDVSIVLAVIAALGLGRLISYPFAGPISDKYGRKVSGLIGNFLHAIFFVGIVFSP
                     NFYIAYVFAIIGGAANSFLDTCVTPSCMEIFASLGTIANMFTKFTIALAQFLLPFIIG
                     FVAANSISFKVIFIVTAILIVVDAFLIAVLPFPPANNVIDNKGKTVKSEKMKFTPTSI
                     ALVCIGFTCTSTFVLWLNCNQELGKLYGMADPTKIQSFYSMGVICAVLITSLLIKKYI
                     KPIRILVIYPIIALLMLLVVYFVQTPTICMLGGFVIGYSAAGGVLQLTTSTANEMFPT
                     NKGKITSIVMIASSIANYVILNIAGIITKSGGVNGPKYVVLFNVAITFVGILLALFVN
                     MRYEKEKVYDYDV"
     gene            complement(37955..38818)
                     /gene="aroE"
                     /locus_tag="KR257_001265"
     CDS             complement(37955..38818)
                     /gene="aroE"
                     /locus_tag="KR257_001265"
                     /EC_number="1.1.1.25"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004455017.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="shikimate dehydrogenase"
                     /protein_id="HBH0029981.1"
                     /translation="MEISGRTGLFALIGTPVGHSKSPVMYNYSFKKLDLDYRYLAFDI
                     TVDKVKEALLAIKTFNIKGANVTMPCKSAVTEYMDELSPAARIIGACNTIVNDNGKLV
                     GHITDGVGYVRNLKENGVEVKGKKITIMGAGGAATAIQVQCALDGAREISIFNPKDDF
                     YKRAEQTVENIKKDVPECVVNLYDLEDTNKLYEEIQSSDILTNATLIGMKPYDNETNI
                     KDTSVLRKDLVVTDVVYNPKKTKMIEDAEANGCKAIGGLGMLLYQGAEAFNLYTGLEM
                     PVEEVNELCFK"
     gene            complement(38900..40822)
                     /locus_tag="KR257_001266"
     CDS             complement(38900..40822)
                     /locus_tag="KR257_001266"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890951.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="FAD-dependent oxidoreductase"
                     /protein_id="HBH0029982.1"
                     /translation="MKISSMFTPIRIGSMTVPNRFVVPPMGNNFANTDGTLSETSKAY
                     YLERALGGFGLITIESSVVDKKAKGGPRKPCLYDDSTIDSFKNVIDACHDAGSKVSIQ
                     LQHAGSEGNEKVAGHPLKAASAIPASNGRNTPLAITTEEIYELIESYGDAALRAQKAG
                     ADAVEVHCAHGYLVSSFISQRTNKRVDEFGGCFENRMRLPRLIIENIRKKVGNSLAIL
                     CRINSTDDVPGGIDVHDSSVIAAYLEDCGIDGLHVSRSIHIHDEYMWAPTTLHAGFSA
                     ELVTEIKKAVSIPVITVGRYTEPQFAELMVRQGRCDLVAFGRQSLADPEMPNKAKNGK
                     LDEMIPCIACLQGCVPNMFQGKPIACLANPILGHEAELKPAEISKEVLVVGGGVGGML
                     AAWVCAKRGHNVTLVEKSEVLGGQMRLAAYPPGKGDITNLVRSYISKCNQYGVKICTN
                     TEATVELIKEKSPDVVIIATGATPLVLPIPGINDSGLIHAVDLLDGKKSCGKKVLVVG
                     GGMVGCEVAAFLGEQEHEVTVIELREEVGADVISEHRKFLMNDFENYNIHTITGAKVS
                     KFYDDGVDYLLTDGTEHDLKGFDSVVLAMGSRNYDPLSEVIKEVVKETYIVGDAVKAR
                     RALDATKEAFEVALNI"
     gene            complement(40886..41734)
                     /locus_tag="KR257_001267"
     CDS             complement(40886..41734)
                     /locus_tag="KR257_001267"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003431459.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sugar phosphate isomerase/epimerase"
                     /protein_id="HBH0029983.1"
                     /translation="MNNQKNLNIPITISSYTLGTEVSFRDRVRIAKEAGFDGIGLRAE
                     NYIDAKNAGVTDEEMIAILNEYDMKVTEVEYITQWGREEDRTEAQREKEQNVYHMAHL
                     FNVKHINCGLLEMIPEEQIITALGELCDRAGELIIGLEFMPYSGVPDLATAWRVVKGC
                     NRENAMLILDTWHWARAKQTAEDLAPVPADKIVSIQVCDVLETPYEKLRDESLHDRLA
                     PGEGYGNTEEFVKIIKEHNISPRVIGAEVISDSLISKGLSTAAETVFNATKKVLDKAW
                     SEVSPK"
     gene            42147..43028
                     /locus_tag="KR257_001268"
     CDS             42147..43028
                     /locus_tag="KR257_001268"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421540.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LysR family transcriptional regulator"
                     /protein_id="HBH0029984.1"
                     /translation="MNLYHLRYFVTLAHLEHYTKAAENLSITQPSLSHAISLLENELG
                     VALFEKEGRNIVLTKYGKIFLKDVEKSLEILDSSVKSLKITGTGEGQIDLAFLRTLGT
                     DFIPDIVHKFLKSNPAKSIDFKFHTGVTTDIIQGLKERKYDIAFCSKLEKEKGIEFIP
                     VAKQDLVLIVPYSHPLAAKDTIDLKETIPYPQIVFNQRSGLRYIIDDMFKKINQQPNI
                     VYEVEEDQVIAGLVAKNFGIAVVPNMNMLSFTKVKVIQIIHPSWERNFYLAFIKDRYL
                     PPAIKNFKNFVIKNAQL"
     gene            complement(43236..44099)
                     /locus_tag="KR257_001269"
     CDS             complement(43236..44099)
                     /locus_tag="KR257_001269"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004455022.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3800 domain-containing protein"
                     /protein_id="HBH0029985.1"
                     /translation="MLSSYVKRVSKIIKKKYIMFIDESGRADINHEDPFTLTGVIFEY
                     KYAVSQGDYVCSLRKEMDAFKEYCFGTSNIGIHLTDISRKSRAFEKFDDSQIKLFYDE
                     LPLFLSRLECTIISVTVDKARLKKYYAPSKEPYVVAFIHVLQNFYSFVNNETVESARI
                     VIESRDDVSNLKVQKAFFDVFNNGTIYLDIDEELRDKVKGFIIAKKEDADYREGLEIA
                     DILCNPLSRARRGLIEANPKCMQYGEKNKIFKSVRNKIYTPTSVNDIRNWGFKEVPIV
                     EPVGPWLEKMR"
     gene            complement(44254..46188)
                     /locus_tag="KR257_001270"
     CDS             complement(44254..46188)
                     /locus_tag="KR257_001270"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861655.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell wall-binding protein Cwp22"
                     /protein_id="HBH0029986.1"
                     /translation="MKKSLKKYLVLALTLVLVFACGVPESSAASKHVIIVNSRKNTLG
                     YFVNNKLVKEFRVATGKKGSETPTGKTKVVNKIKNRPYYKGNIPGGSPRNPLGDRWMG
                     LALKGTYGDTYGIHGNNNESSIGKHISGGCIRMHNKDVRWLFDQVPVGSDVIIDYSND
                     SYVKIAAKYKINLNQTGWKTENGKKYYVKSDGTYQKNSWLKVNGKMYYFDASGVMQTG
                     WKTINNKKYYLGTDGARVSGWKVIDGKTYYFNSDGVMQTGWQEKNGKKYYLGSDGLAV
                     TGWQEIDGNKYYFDKTGIMQTGWQQIDGKSYYLDKDGKMLTGSQKIDGKDYTFNEDGT
                     INPTWDTIIGANRFDTAKKISSVGNWNADSSDTVILVNGNAIADGITATPLASSYDST
                     ILLTNTANLPTETVEEMKLLAPKTVILIGGENAISSKLEQEIKTTFNTETKRIAGQDR
                     YQTATRIAEELGNREEIKTAYMVSGNGEADALSVASKAGEEKQPIILVNKDGITEESY
                     KWLTERKLENAYFIGGPSAINDSVIAKMNDITTEDISGNRIYGDSRVDTNAKVIEKFY
                     GDTDLQAVLVSKSDALVDALSAGPLAVKLHSPIVLMDNSGLSSEQQRVFANKKVETPY
                     QIGGGVSYIVMDKLMDILAK"
     gene            complement(46300..47313)
                     /gene="galE"
                     /locus_tag="KR257_001271"
     CDS             complement(46300..47313)
                     /gene="galE"
                     /locus_tag="KR257_001271"
                     /EC_number="5.1.3.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861656.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-glucose 4-epimerase GalE"
                     /protein_id="HBH0029987.1"
                     /translation="MAVLVAGGAGYIGSHTAIELLESGYEVVIVDNLSNSNSIVVDRI
                     KELSKKPVKFYNIDIRNKDEMHVVFKENNIESIIHFAALKAVGESVEKPIEYYSNNLI
                     STLNLFELMREYGVKKFVFSSSATVYGDPHTCPILEDFPLSVTNPYGRTKLMIEQMLV
                     DISKADKSLDIALLRYFNPVGAHKSGRIGEEPNGVPSNLMPYITKIAVGKLKELSVYG
                     NDYPTHDGTGVRDYIHVLDLAAGHVKALQKLEENPGLVVYNLGTGKGYSVLDLVKAFS
                     KASGKEIPYKIVGRRAGDVAMCYADSSKAEKELGWKAKYELEEMCEDSWRWQSMNPNG
                     YEE"
     gene            complement(47337..48206)
                     /gene="galU"
                     /locus_tag="KR257_001272"
     CDS             complement(47337..48206)
                     /gene="galU"
                     /locus_tag="KR257_001272"
                     /EC_number="2.7.7.9"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011018342.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="UTP--glucose-1-phosphate uridylyltransferase
                     GalU"
                     /protein_id="HBH0029988.1"
                     /translation="MTVKKAIIPAAGLGTRFLPATKSQPKEMLPIVDKPTLQYIIEEA
                     IESGIEEILIITGRNKKSIEDHFDKSVELELELEQKGKTEMLEMVRDISNMVNIHYIR
                     QKEPKGLGHAIYCAKSFIGDEPFAVLLGDDIVDSDVPCLKQLIDTYNEYKTTVLGVQK
                     IAKEDTNKYGILDVKHIEDRVYKVKDMVEKPAIEEAPSDIAILGRYIITPAIFSILEK
                     QTPGKGGEIQLTDALQTLGKQEAIYAYNFEGRRYDVGDKIGFLEATIDFALKRENLKD
                     DLMDYMRKKVSEK"
     gene            complement(48404..48724)
                     /locus_tag="KR257_001273"
     CDS             complement(48404..48724)
                     /locus_tag="KR257_001273"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421530.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0029989.1"
                     /translation="MSSKYNVWTFNYEFLGLDSGDEKNNEVYYEIDLDEILNENYIDE
                     DIDSGLDSDGNSILGELISEMDIDEDVSVDMTYQELEVDLEDLDSYLDEDIDSDIKGI
                     LDEI"
     gene            complement(48714..50705)
                     /locus_tag="KR257_001274"
     CDS             complement(48714..50705)
                     /locus_tag="KR257_001274"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728664.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0029990.1"
                     /translation="MLKLGEKIIYELSDGFELSGISRYSKEYKKLHITNLGNIIISKS
                     DEVNEDTGVKYIYSFSDNKEKLEAVLEDSQIIVYGNNLPFYIKSENSSKNVTANLTMK
                     ITLDEYDLICKSQREFIFYLKDNMTILSLDDNKFYMGGINKDNEKFIFISGKNRFEIN
                     FDDIERYILEDKRVSLKGYFHMEREGIIVRSVSIFNNNIDSVVPSDLNERVKDNQKIG
                     NLPKDCEIVFCKISGNIDGFDYKNTNMLLVKYQDQLIFINKKSKKTIVKSAKDNCSKL
                     NLGEDIILYDNKNVFNLHINDKNREIMQIDDLKDIENEIVGYTLKHAPFFIQEDFDSL
                     TILKSFQKEIISIKNSDIKDIVINKELENENSNFVETEIKFNNQKVLLNLSKSMVQKL
                     MQDVFIYAKQPLLKENSIEVIYKNWSKAMNDMIIFNFFGNIYYMKSEFDKILEKELND
                     EIRIEVINSLYKQIQEQRNNLDLLSAYMPRILENQEIDLFEKYNTKLDVQVFKQIKNL
                     LSDLSYNISSYLNEVEKSLDNIIFVISGEDKKKYNYRMLKESESASLDVFLKQAISRL
                     NHLVENMYPYYVDETSREMFKLFELLWKNYRNIDDDSIKEILFERITNTYVFKQLTLN
                     NSTKERRKDIIEKIYNSVDYGTNKLDENMFFTGGIKYVK"
     gene            complement(50828..53371)
                     /locus_tag="KR257_001275"
     CDS             complement(50828..53371)
                     /locus_tag="KR257_001275"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012816330.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SPOR domain-containing protein"
                     /protein_id="HBH0029991.1"
                     /translation="MKVLSENNIIRNTVLNVTASFLKQESKINEKLDGVLEKKFEKVE
                     FNEAKYAELLKFNILFYKTLARNTEPLIGKWIVDKYIPEIDELEKDLELTTAKCRKYV
                     NKAMKEGLDSLKANDLNSFLAYDKMELSERRRRLEKDYKVLNLYKDLLNISLRKISLE
                     KKECGDLFLKNQADAKRELKREIIFCVNKILASNKDVVPNNVEENNEQNKVEIKATEI
                     EDLQLGKDNSENDMLLNEIKNSKVKHESKSNDIESKFIDKLNSLNNESISQTIHNEYK
                     KLCGLEELHSVEAYGFGKEIIKDFACATVVLEFLKRRNRDLIEGAMRLTIIGEFGPEN
                     FKEFVDYVIKNKTEISEDTWNKAQNLIKDNYSELENHEIASKRTRRNKDIDIEEYIYM
                     IKNADKDICFRSSISIEDDAEEGTKEEVDSNNQDIGDVVEDKDTTDKEYDSNKEDIIE
                     PENKKSKKKAKLFGFIKKDNEEAEQEEENLNDISPDIILDKPVENHQVKSEEIEQNEL
                     KEIKQEEPSQHIEEERSVKIEKPINNNLDEKVSSNNESKLEKESKNLEDKKAKEIKEE
                     KLENEKSVVIPIKKKENSNKKSKNSSKDKYRENKKEMKNYVSDKEDSLDDEEVVSKKS
                     RLKETIIAVVIVVIVGVGYFITVGNNKKNDKENIPKSSTQQQANNKLTEEEKKAQAEK
                     EKKEAEEKAKAEKEAQEKAQAEKKAKEMEAYKDGKGVYYTVYAGSLKVEKTAKETAKE
                     YEAKGISSTIIQENGYYKIKIGDYSQYGEAQEKCNELAKKSIDTYIAMYDKYYDYKLE
                     ELKESAPSLSAEELKQKYEDLRSELKNKSGYREYVKHLDKLYEEIVEGA"
     gene            complement(53649..53983)
                     /gene="rnpB"
                     /locus_tag="KR257_001276"
     ncRNA           complement(53649..53983)
                     /ncRNA_class="RNase_P_RNA"
                     /gene="rnpB"
                     /locus_tag="KR257_001276"
                     /product="RNase P RNA component class A"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00010"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: cmsearch."
                     /db_xref="RFAM:RF00010"
     gene            54115..54792
                     /gene="srtB"
                     /locus_tag="KR257_001277"
     CDS             54115..54792
                     /gene="srtB"
                     /locus_tag="KR257_001277"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903304.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sortase SrtB"
                     /protein_id="HBH0029992.1"
                     /translation="MKKLYRIVINIILVLVILYSGFNIYSKLTKYNHDTKISSELQKK
                     EYKKEDLSKINSDFKFWLSVENTNINYPVVQSKDNSYYLDKDFYKKDSISGTLFMDYR
                     NKSIDDKNIIIYGHNMKNKTMFNNLNKFKDADFFKKNNKIKITLNGKEFLYDVFSAYI
                     VESDYDYLKTNFNNESDYQNYINDITSKSLYKSPIKVNSNDKIVTLSTCTYEFDDARM
                     VIHGRLI"
     gene            complement(54952..55026)
                     /locus_tag="KR257_001278"
     tRNA            complement(54952..55026)
                     /locus_tag="KR257_001278"
                     /product="tRNA-Thr"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:complement(54992..54994),aa:Thr,seq:tgt)
BASE COUNT        17014 a        10533 c         7468 g        20056 t
ORIGIN      
        1 atgccgacgt gggttacata cgaaccagcg ttataggtag aatggaaaaa caccaagtcc
       61 ccagcctttg cctgcgaaag cggaagatgt tgggtagcgt catattgtgc ttgtgcggtt
      121 ctcggcaagg agataccagc ttttccatag caccattgca caagtccgct acaatcaaag
      181 gaagtgttgg ggttactgcc accatacaca tacttccagc cttgatattt caacgcttca
      241 ttcataatcg cttgtgccgt cgcattatca aagtgtgcca cggtcaaata ttgattgact
      301 aattccacat agaacatatt tccatagcca taccgccagc ccccgttctt cgcaacggct
      361 atcgggttgg tgtaggttac tttctttcca cccgattttt cacgggcgaa gctctctgca
      421 aggttaaagg tgtgtttttt ctcttttcct gccacatatc ccacatagcc accgccatag
      481 ttataagact gtatcgctac attcaaatcg tcgatacctt gatttttgca ggaagaaagc
      541 agggacgcaa aatatttaca cccctgctta attgaacttt ctgtatctaa ggaattaggc
      601 ggtaaaccaa gactttccga actctgcata acatcttctg ccgtaccgcc actttctact
      661 tgaatgatag caagcaatac attgacatac tcggagatac cgttttctct ggcgtatttt
      721 tctaccatag gctgatgttt caagacttct gcggataagt tcatacccgt aatgccagaa
      781 gaaaaattgc tgttctcgtc gtcgctgtcc gcactaatca acaccccaaa gaaaagcacc
      841 agagaaaaga ggataggaaa cagactgcca atgagagcga tatgtttcag tttcattttt
      901 tcttctgtcc tttcttcgtt acaaggttac gggttttctc tgtggtctgc tgaacctttg
      961 tcctacggtc tttggtgtaa ttctggcgtg tttcctgcga taccactttt tctacatttt
     1021 gcctatgtgt tatctgtgcc gactgggtcg ctttcttatc agaagcacca gaagataacg
     1081 gacgctcttt gataacattt gtcttgactg gctcacttgc tttcggagtt tgagctatgg
     1141 cagggcgttt gacttcctgc attttttccg cactcggctt tgaagctgtg gctggtcgct
     1201 catggggacg ggtagctccc gttgtcgctg atccgtcagc ctttcgctgt gcctgccttg
     1261 cttcttgtgc cttttgaagc tccatacgct tgtcagcgat atttttctta tgctgttcct
     1321 gcttttccaa acgccccgac tgtctggact gctgttcctg taccatgcca cgcttaaagt
     1381 cggacacgct ggactttgcc ttttcctttg cggaatacac cgcataagcg gtctgtgttg
     1441 gcatatcctt tgctggaagt agaggtattg ccccgactgt cttttgtagc tgtgttcctt
     1501 gtcggttttc tgtttgaaat cgtgctacct gccaccgcac cagcaacacc gccagcagta
     1561 accgcaccag caagccgtct ttccatacgc ctagccctat gtgccaagta tagatatggt
     1621 ctgcggaaaa ttcttcgtcc catgctttga ctgtcgttag cgttcaaaga gaacatactc
     1681 attaaatcgc ccagcttcat gtagatacct gcgaaacaca ctatctgtaa gaacgctacc
     1741 ataaagaacg gatagtccgt ggatatatta taaaacatac tggaaatgct gaacgccacc
     1801 gttacaatga gcgttattcc tgcccgtgtc attatggtat taaacaccct tacgattgcc
     1861 tgctttgcca tgctttcata gctcggtatc atggaaagta aaaagctgat aggcagaaac
     1921 atagcgaaga taataaaaag tatctggctg aacaacatca tgcccgtaag caagaataca
     1981 aatatcgtta tccctaagtt gaagaacagg aggaagaaca ccatacccaa gcggtttacc
     2041 acctgcggta tcgtcagatt gttgttgtcg ttgtcctcga tttctgtttt cacgacttcc
     2101 tctctggtct ttccgtcctc gacctctgga cttgccgata caagagcttc tacacggttt
     2161 gtcccgattt cctctgcgtt gctgttcccg aattgtaaga gtagccacgg ctgttccact
     2221 tgaatagaaa ataagctgtc ccgtatcaag tccacgctgt ccttgccctc gctgtcagag
     2281 tttgggagca tgatttttgt tcccaaatca agtgaagcgg tactaatatc tgatgaaaat
     2341 tcatttatct ttttgatgta gtcgggagcg taggcaataa acgaagcgga cagcacgaac
     2401 accaccacaa agttgataac tgcgtgaagt gccttgctgg tttctctttt tatcagtccc
     2461 gtataggcaa cataaagtcc caccaccaag ataatgagaa gcaggaaacc aacatagaag
     2521 ccagagctgg aaaaaccgtt ctgtgttacg cctgcaaggg tctgtatgct ctttccgata
     2581 ctgtctgcca tatcgttaat aaaatcaagt ttataggctt cctgcaccac atagcccgtg
     2641 gcattgctca aataaaggct tatcgtccag acaaagttgg taatacagta aagcccgtac
     2701 tgcaccgatt ttccaatccc gtctagccag ttccacggaa gccacgacca gctattatct
     2761 acataaaaat caagctggta gttggaaagg gggtattttg agtaaagatt ttctacgttt
     2821 atggtatcgt ccacaagccc cgtcgcatga gctaccgtcc ccagaagtga aagcaggata
     2881 agggagagtg ccactacgaa cagagccatt ttgagaaagt ggaaaatctt cttttttgtg
     2941 aacgcacctt ttatcctttc tttcatcact ccacctcatt tctctgtacg ggcggtcttg
     3001 tatcaaaggc gtgtagcagt tcttcaaaaa cggggtgtat ctgtaccaca ccgacacgcc
     3061 cgtataagtc ctgcaataag cattgtccgt tctccaaatc acgcaagcgt ttctggttgt
     3121 tctcgtcgtc cttgtcgata ccgaaaaact ctaaggtctg ctttatctcg ttgatgtcag
     3181 tagaacggaa agcgaatttt aaaccgatat tgtttttcag actttccttt gacacgtcgc
     3241 cagaagattg tgtaacaaaa taaacgcctg cctgcatagc tcgtccagca cgaaccagct
     3301 tatttgataa ggtttcgcct tgtgccacat ttaagaacgc ccacgcttcg tcaaggtcta
     3361 caatcttaaa aatacttctg tctgaatgga taaaatcaag ggcaaaggta ctaatcacaa
     3421 tcagcattgc caccgataat aattcaatgg tcgtgtattc gttaaaagtg gtatctttat
     3481 ctggcagtac aaggtcagct acttgaatga tattgagctg gttatccaga ctgattgtat
     3541 tttctactgt cccgtccgaa aacagcagat gtgcaaaatc ataatttgta aaactggcaa
     3601 tatgatttgc gatatggttc gcaatcggtg tattctcttg ccgtaattct gtgataacat
     3661 ttaacagtcc tctgtgttcg ctttcagata ccttgctgat tgcactaata agcacaggga
     3721 atttatctcc gtcacgggta gagatacccg ttaaaaatgt taagatttct tttgccagcg
     3781 tcgctccgtc ctctttatct ttcataatca caaatgggtc aagaagtcct gcattgtcct
     3841 tgtcgctggt aaggtttacg atattgattt cacgggctat ctctgggagc gtttctttcc
     3901 agttgccacg ctctgattta gggtctaaga taaccgcttg accgccaaac agcacagcat
     3961 aatacaccag aagattgttg cagaacgact tcccaccgcc aagcgaaccg acaaaagcag
     4021 aagcaagggc atttgtaact gtgcctttta cgccctgcga agctaaagac ggttgcaggt
     4081 acacatttct tcccgtatca acggaatagc ccatatagat acccgtagtt tctcctaact
     4141 gctgtgtagc accaaaacca agccctgcca agaaatctga ttttacatac tgcacatagt
     4201 cattgatata tcgcttgctg gctggaagaa attcagaatg aagccccagc atatccccag
     4261 caggacgcac caactttaca ttgaggtcgt cgtaaaagtc cttgacttca tcacaacggc
     4321 gtttcagctc gtcaagatcg ggtgcagaca cccgtatcac gtagcttaac ttatacatac
     4381 tttctttgct ctggtctaag tctgtttcca gctcgtccac gctgtctaag gcgtccacca
     4441 catttgagct ggtttcactt cctgcttgat aagcgtgatt gtcaaggtct ttcaattcct
     4501 ttttcttgtt tcttactgtc gttaatgctt ttcggttctc cacgatttct acattcatag
     4561 aagtatcaac ggggaatgtg aattgctgtt gctggaaata gaagatttca gacgacggaa
     4621 aatcaagctc cccgacaatc gcattgacag taaagtagga cacataactt tccttgtcct
     4681 catgttccaa tcgtaaatac cgctggcttt cctcaatcac acaccttgtc ggacggataa
     4741 ggtcgtagta ttttatcagc gtttctttgt tcaatttttt ctttggtagc tggtactcat
     4801 aatcttcata ggcgataccg tccctgccgt aaagatgttc catgagatac ccaaaatcat
     4861 tgatttccaa gcgacgcacc ttaaaacgcc ttgatatttt attttccagt aacttttcca
     4921 ttttcatgta acggttgatt tcatcattcg gcatggaaac aaagtcattc atcagcgtgt
     4981 ggttcacttc atggagaaat tccgtaaacg tcagccacgc cgattttttg atgttcttca
     5041 gattgagctg ttcttccgta accatgagct taaagccaag aaaaaaacgg tagtccactt
     5101 gattgtcccc aatcatagat actaacgctt cggtctgttc gtctatcttc tgataggcaa
     5161 cttcctttaa ttttccagtt accagtttct ttgactgttc ctgcatactt cgtatggagc
     5221 tttctgtggc aatctgcaag gcatgaattt taccctcacg ggactgtgcg ataagctggc
     5281 gaaagctgtc atgcacgata aatttctgct ctgcggatag gaaagaatag ttatacggta
     5341 tcaactcata gtaagcgaac acctcattgt ccttgttcca gacaaggtta ttgtcaatat
     5401 attttatcgg gaacatagtt cacactcctt actgccgtga ttgtttcatt caaggtctgc
     5461 ttatgcagtt ttacggcttt tcctgcataa gtgattttag gtcgcaacgc ataagttatc
     5521 tgtgatttca aaaagctgta cggcttcttt ccgtcaaagg tcttttgcga cataaaccaa
     5581 gtgagagcaa cgggaatacc aaagtatttg agaaatgctc cctcaatcat ggaaagtgga
     5641 ggaatatccc caaacagaat gatgataaat tccgtaatca caaaccatgt aatctgtgta
     5701 aaggtaacgg gaaagggtaa gttaaagtca ttgattgcat acaagacttt ttccacgttc
     5761 cagatacccg tataagattt aatctttttc aagttctttc agctcctttc gtaagtttct
     5821 aaatggaaaa ggacagccat tttcagactg tcccttaaag agaaatacgc tgtcagtagc
     5881 aacaatgctt gtcgctgatc ttccagcgtt agtatggtat ctcgcacata cctcggcttg
     5941 tttcaatgaa gcaaccgccc atatccaaat ctcgcccgta ggcttcatag tcaatgtagt
     6001 tctgcaagct gggtggaata tcccctagtg cctgcaattc gtctatgtag tagtaggcaa
     6061 catctgtcat ggtttcacag tcgggataat aataaatatc gtccttgtgt tccacgactt
     6121 cttccagcgt cccaaagtgg ctgataaatt cgtccagaca ctctacgata tagtcgggaa
     6181 gttcctctat catttcatac atctcgttga gttcttcaat ggaaacatac tcgccaatcg
     6241 caatggggaa gttgtcggta tcatggatag cgtattcctc atactgttca ttcaagccga
     6301 ttttttcttt tacatcttcc tcgtcaatgg gaaacgtgaa ccaagcaccg actaaatagc
     6361 cctcattgta tttgccaaga ttagcaatat aaaccgccat atcatcaatc ataagcacca
     6421 cctcatttcc tactctggca gttcaaagat accgtgttcc gttactaaaa atttcccgtg
     6481 ttcctgtaag tgagaagcgt aggcttcaaa atcgaaatag tattcttgac agtcctcgga
     6541 cagatgttta aatgtcgggt cgttcatcag cttttgcctt gcaacatcta tcatgctttt
     6601 gcagtctgga taaacggtaa tcacgttcct gcaaatataa agtgcttcta aattttcaaa
     6661 caccgtaagt agtgatacat attcttcctg catatcactt gaaagctggc ggtacataaa
     6721 atctaattca ttgagctgat acacgcttgt atgttcgtgg acttcatcag cataaggcaa
     6781 caccttttca ataatacggt aatccccact ttctgcaccg acacctagct tttcttcaaa
     6841 ctcggcaaca tctatcggca gttcaaacca gtatgatatt gtttcttcgc cagttgttcc
     6901 tctcgtttcc accagcaccc ttgtttcctg cattgttcct cacgtccttt ctgttgtttc
     6961 atcacatctt ttaaggtctg gtacgacata ccaaacacat atttagaaaa atcttctaac
     7021 tgtctttctt catagtcagc aaggttcagt cgtttcattt catgccatac cttacgcttg
     7081 taagagggca ggtcagaaat ataatcacag ccgacttttg actgcatatc cttaaaaata
     7141 tcgttcatgt aatcactcca atctgaaatt taagtatgaa aaaagcagtc aatcctaaga
     7201 ctaactgctt tgtgtgtagg gatatgaaat tgtttatcag acatattgtt tgaaaaatac
     7261 atttaacttt tgccctaata gtgttggatt atctgtattt acttcatgtc ctgcattttc
     7321 aataatagct atttctgcgt tttctatctg ttgttgcaat tctaaagaag cttttttatt
     7381 tatcttatcc ttatcgccac agacaacaag taccgaacat gatatttttt tcagttcatg
     7441 tttaaaatta agttccatca tagatttgca tagattgata aaatctgttt tccgaaagcc
     7501 cattttttca aacgctgaac aaggcataat acgaaatatc agattttgca tttttaacag
     7561 atactttggc atttcatatt gtgttcctat taacactaat gagttcactt tttctgggtg
     7621 ttctatcgca tactgcatag caagaatacc acctaaagaa agtccacaaa tatttagcgg
     7681 ttcttcaaac tgttcacagt atgtttccaa tgtccgatac aatgtatcat aacatggtgt
     7741 tttcccagaa agccaatctg ataaattagg gcataaaact tcaaaatcat cattgaatac
     7801 ttttacggta tcactccaac tttcagaaga ttgtcccaaa ccatgaagca ttatatattt
     7861 catttcatca ctcctagata ctgtgtttca tatccacatt ataccattcg catatcagca
     7921 ccacaataaa attttatgca ccgataatct tattgaacag ctctaacagt acatctttca
     7981 caccgccagc attgaatacc aagccgacag caatcaaggc aactaccaag aagccgataa
     8041 gtttggaaaa ctcacgcttg aaacctaagt agataccgat aaccacaatc gccataagca
     8101 ctaagctctg tgcgtttgat aaaaaccatt gatataaatt ttgtccgaaa ttcatttaat
     8161 tgtcctcgct ttcttctaat tgtttcattt tatagtcagc ttctttgcca acattcaaaa
     8221 tacacatcaa gactacgcca atacccattc ccatagatac cagcaggaaa tctttcaata
     8281 atacccacat ttttcatcac tcctaacttt ctactaaatc ttttgcaggg gtcgtctgct
     8341 gtttgattat catttcatgc ttttctgtga gctttgcctg ctgttcgatt gtatccatgt
     8401 agtctgtacc gtttccttta tcaatctttt tcagcatttt caaggtcggt gctacctgcc
     8461 tttgtaccca acgcaatgtg cggtctaagg tgtaaggctc tggctttgtc gtcagcttca
     8521 aactctgtct gttatcgccg ataaaccaag cccagcggtc attgagtttc cagtcatttt
     8581 ttcgcttgtc tggttcttca tcaacaaacc gcacatactg attgataata gaaaaggcgg
     8641 tctgctctgc gtcataatag gtcagcaaat ctcgtactgc ataataggca cgttcattgc
     8701 gaagccgtat ctcgaaacgg ttgataatgt cggcttcttc cagaggtgtc cccagcttga
     8761 cgtactgctc ataatccttt tcatagatac agaaatatac atcagatttc agcgaaccaa
     8821 gataaagggt acgccccata tattctctgt cgtcctctct gtgcttgata agctcgcccg
     8881 actggtagaa cttataactt ctggacttcc cgatatattc ccgtttcctg catttttccg
     8941 caagctctgg aatatccaaa atgcccgtat ggtcgttgat agcaaggtcg atacgcttca
     9001 tcacgccacc gtctatgagt gcgtccatga ggaagtcata ccagcttctt tgctgtgcca
     9061 gcaggtaact ttcaaactgt cggcaacccc gaccctttaa ctctaaaagg acaccttttt
     9121 cttcgtcaga cgacgtatag ataaagatgt cccctaaaga gtaatgctcc gtataactgt
     9181 aatgtccgta atcttcatgg agcatataat tgatattcag ttttaatata tctttgatga
     9241 tgtgctgtat atccagcgtg gaaaaacgaa ttttcacata atcaaacagc atggtaagcg
     9301 gtgcttctgg attgaacctt gccagttcct catgcagaat attaagaagt tcctttgacg
     9361 gcttcatttt tccgctttct atcttgttga ggtattctct tgtaatgcca gaagctaacg
     9421 ccaacctgcc ttgtgagata ccgtaagcaa tccgtttctc ccgtaattct tttatccatt
     9481 gttcttcatt cagaaccata cccccaatct gtaacgtgtg aagtttttta aggcgacttc
     9541 acagccgatt tttgctagga aaccatgtca gaagccttat gtttcctatg ttttttgtct
     9601 attgtctatt tgcaaacgta cccctctgtt agataccgag gggttcatca gcagagcagg
     9661 gacaagccct gctctgcaaa acggcttcca cggtcgtatt tgctccgccg accgttcctg
     9721 ccgttgtgca ggcagaacct atcctacctg ttcataccaa tgtaaaccat gatgaatgaa
     9781 acatcagcgg ataaacataa atttaatgtt tcttctgata tttcactttt acggataggg
     9841 tctgtttcca gaaaagactt atccagcaat tcaaaaacaa aatcaatctg gctgttgcaa
     9901 gccgactgtt ttctatttaa gcgtatcaag aacaaatcgg gcatgaagtt tttttcgtga
     9961 attgcatttt caagaatagt atcagctttt ttctcaaact gatgttttgg attacattta
    10021 aaatcgtgat aacgtttctg cacaaatccc tcgcaatcgg ctagaaaatc tccataattg
    10081 atacagatac attttacgct cttaactttc tcgtctttat cttctgattg tattatttta
    10141 ttgatttctt ttatttccat gagttagttc tcctttcctt gttgttctgg cataacttgt
    10201 ctttcttgtg caagcctgcc gattgtttgt aaaaaatcat gtccttttgg gactaaaggc
    10261 gtgtaaaatt cgcttataac gcttgttccc acatcacaat agccacgccc cttgatacgc
    10321 ttctggaaaa actgcttttt cacatctgaa ccaaacagca taccgtaacc taattcgctg
    10381 atacgcccaa gtcccacacg gaaattgaag ttatctctga taccgtccga gaaatacttt
    10441 gcgtctggac gctggcaggc aacgataagg aaataacctg cttgtcgccc taacataacg
    10501 attttcttta actggctaag taaacccacg ctttctttcg tcccaagcat ttcaaaaaac
    10561 gccacatatt catcaaagat aagaaagcag gggggtagtc ccagataggc gtagttttcg
    10621 cccgtcttat agttcgggtg tcgcttcatt tcctcacttc gctgtaccat gccctcataa
    10681 aaagcattaa cgcaatcaat catttcttct ttggtatgat acacatttcc cataaccgtt
    10741 cccaagtcgg caaggtcgct attcttcggg tctaagatat aaaggacagc gtttgtgtgc
    10801 agtaaggctt caatgagcgt cagcagaaaa taggttttac cgccaccagt cccaccagcg
    10861 ataagggcgt gagggagtgc gtcatattcc cagacaagat ttttcattag tctaagacag
    10921 ccattctctg cccgtacttc atcaatggta atgcggttcg ctatcatatc ataaagcagg
    10981 gtatattcga tataaccgtc atgcaaggtc ttgtcggtca actcacaata caagccactt
    11041 tcaaatttat cctctaaccg taaaagctgg tcttgatatt ttcccagcgt aatttcacag
    11101 cagatatgaa gcagtccctt ttccatttga taataaatct ttggaaacca gacgattttt
    11161 tctcttgatc tgctttgcag gtcagtaaaa aaaccgctgt cttgtacggt atcggcttca
    11221 taccacttat tttccagtat cattcgtgcc agcttttgac ggtgcaggag cttcttgaaa
    11281 ctgtcgtaac agaagcggta atacagaaaa gcgaccaata cacaaacacc agtcgctatc
    11341 agtatcgtta tgaaattgta aggggaaagt atcaagccat tttgtaacaa gctgaaatgc
    11401 tcccagttgg tacgcatgag ctgtttgcta ttcaatagca ggagaaccgc catgaataca
    11461 aacagaagcg tccctatgca gtagtggtag acaaggtgct tgtcgctggc tctgatacgg
    11521 tgtcctttgt taaaaatctt acgcataaat caatcactcc tttctgggta cgaaaaaagc
    11581 agtcaatcct aagactaact gctttgaaat aatatctact tatttttatg ttgtgttaag
    11641 taatctatac caaaacatat aagggcaata gcaaatgtga ttatgccatt aaatacatca
    11701 gattttgaaa caatttcata ttgcggtaag aaatagtctg taacacgaac aatgacaatc
    11761 ggaacaaata tcaaaagtaa cagagaaaac cctaaactaa gaaatatgcg ttgatgatac
    11821 ttgcgaaaaa ttccataaat agcccacata atcgcaatac aaaggactga aatacaactg
    11881 ccaagtgtaa aaatggtcgt tacctttaat aacaaggcaa gtattgctaa aaatgggata
    11941 ggaataatac tgcatattat caatgtctta aaaattactt tttccttgaa aagcatacaa
    12001 ggcaggaata caagccaaac tgcaataatt gcttcaatag ctataaaaga ccaagatagc
    12061 ttatcagaag taaaataatc acaaataaga caaactatgc ttgctattaa agcaactatt
    12121 gatattgcaa caaacattgt gcgtttgctt ctttcagaga agtaatattg atacctcttt
    12181 tttctgaatg gtaattcatc aggcttcgtt aattcttcct tgataagata atcggcagat
    12241 acattgaaaa tgttactaag ttgagctata aagtctaaat ctggttctga ttgatttagc
    12301 tcccattttg aaatagtttg tcgagtaacc gttactttct ctgcaagttc ttcttgtgaa
    12361 aacccatttt gttttcttaa tttttgtatt ttctctccaa gtgtcataga cattctcctt
    12421 ttatcgttat ttgcataaaa tcataaaaaa taaaatgtcc tatgtctacc aacattagct
    12481 ggaattaacg caacgaacca ttgcaacagc gtatttatag gcatttacag cttttagatt
    12541 actttgcttt ttacctttcg gtattatgag aactattgaa aaaaacattt aattcatttc
    12601 ccaatttaat aggagcgtct atatttactt catgtcctgc accagatata atcgtaattt
    12661 ttgcgtatgg tattaaattt cctaattgta gggacgctga tttattcggt ttatcttttt
    12721 ccccacatat aaccaataca cgacaagaaa tatctttcaa attatgggta aaatctaaat
    12781 caatcataga cttgcataag ctgataaaat ctgctttttg aaaccccatt tttgaaaaca
    12841 ttgagctagg cataaattga aacatgatat tttgcatttt tagtaatttt tttggcattg
    12901 catactgtgt tcctatcagc actaaagaat gtaccttttc tgaatgttca atactgtatt
    12961 gcatagcaag aataccacct agagataacc cacacagcgt tagcggttcg ttgaactgtt
    13021 tacagcacct ttccaacgct ttatataaag tttcatagca ggggcgttca ttatatagcc
    13081 agtctgcaag attaggacac aatatatccc acttatcact cattacttct aatgttttat
    13141 tccaactgaa agaagtctgc cccagtccat gtagaaaaat atatttcatt ttgtttcact
    13201 cctacatttt gatataccac ttattatagc aggtatcaca tatccgctac aatgaaaatc
    13261 tattcagcaa gcctattttt tctgctgtcc ctgcgaattg ttgttctgtg gactgcctgc
    13321 gttctggttg cctttattct tcaatacaat atcctctgcc tttacatacc agtccacatc
    13381 tgcacccgta taggtttttc gtgataccgt atcggctact ggattgacaa gctccacgac
    13441 tgcattgtac ggaaattccc ttaacggtac ttctggcggt acggacacgg ggataattcc
    13501 accatgcaga ctgcacttca aatcatagat acgcttttta agctgggtac tcggtgtccc
    13561 gtcctcattc tgcaagaaca catcacgcac cgctgtaaat tttaattctc caaatgtttt
    13621 ctctctgtca ataacaaaac cgtttgataa tctcataaat tcttcactcc tttacttttc
    13681 ttcaactgct acaatatcat cagcaactaa cacataatcg gtatgtccca tatccccgat
    13741 tgcgtaacct ctgccgtata acttcggatt gacaagtttt actttctgct catacttgaa
    13801 cttcttttcg ccagcctgca cgggaatttc taccacaaca ttttcgcctt tctgtacgtc
    13861 agaataaagg ttatagcttc gtctggctaa gaccctgcgg ttatttttat ctctttcaaa
    13921 gactggctca ctttcgcctg caaattcaag agttccaaaa gactgtgcca tatctggcac
    13981 gacatatttc atttccatat tgttttacct cgtttctttc tatttttgat aaattgattg
    14041 tgatttctta ttctggcggt tcgggaagta ccagcaatcc cccagatagt aaagggtaaa
    14101 atcaatgctt acgcaccctt gactatccgt gttcttgcag gttggtggca gacaagccag
    14161 aataagcgga agtctgccgt ttgaccgctt cggcggagag cgtgattttt ctttcctcat
    14221 accgttaccg ccttatgagt tcttcatttt acggcgtttg tagaagaaga tacctgccag
    14281 tccaccagca gacgcaagca acatcacaac aaatgccatt acatttgtac tgtcgcccgt
    14341 tttgggactg tcgctcggtc tgctaggctt ttctggtgtc ggtggtgttt cgggtttttc
    14401 tggttcttct ggcttttcct taaaggtaat cgtctgtccc ttatcctcaa tatccttatg
    14461 ctcggtaact ttcttcggtt cgtctggatt gcttaaatcg tacaattcct caaaagttac
    14521 aagctgtttg ccgtcaagag aagtagcgtc aaaggtaaag acaacttcca ctttcatagt
    14581 ttcgctatct gcggtaaagg tataatcact ttccacacgt tttccattga taagaagctc
    14641 tatattttct tctttcaaca tctgccagcc cacaagtttg tactgtgtac cgacttctaa
    14701 tccctctaag gttacggtat caatgattgt aacgtctttt ccagcttcaa gctctttgtt
    14761 gccgtcctta tcggtagcag tcgtatgaat tttgatgata cgctctgtga taagtaccgt
    14821 ttgcccgtcg tcctcaatgt ctttgtgttc cgcaactttt acgggttcgt ctggattgct
    14881 taaatcatac aattcttcaa aggtaacaag gttcttgcca cctaaagcag acgcattgaa
    14941 tgtataggaa atttctactt tcatttcttc ctcatcagcg acaaaggtat aatcgttttc
    15001 tacacgtttc ccgtcaatga taagttcagc gttttcttcc tttaacatct gccagccttt
    15061 gagctgatat tttgtacctt tttccaagcc gtccagcttc acagtatcaa caatcgtaac
    15121 ctcttttcct gcaaggatag tcttttcgcc gtctttgctg gttgctgtgg tatggataga
    15181 gatttctttt tcgtattcat cagtcagcgt ccctaaatca atcacaaggt tatttcttga
    15241 taccacgatt tcaaaaggtg ggataagttc aaagcctttg ttgctgtcag agcgtaattc
    15301 ctcaatgatg taagtatcat aaggtaacgc acccttgctg tcgtctggtt cagaagttcc
    15361 aaaccacaca ccgtcctcgc tggtttttcc tgcgttggta ttgtgcttat gagaagccca
    15421 gtcagcagaa gtggagaatt gcccgttatc atcagttaca acaacatgac tttcacctgt
    15481 cgtcttgctt gtgatcctaa agggaacatc agcaagacgc ttgtgtgtgc ctgcaccgat
    15541 tttcacaccc tcaatatctc cacgcttaat ctgattgtag atagagtggg cttcgtcggt
    15601 taagtccaca attttaccat tttctgtgat tgcaaagtca atcggtttcg caccgtctgt
    15661 caaatatccg tctggagctt cgctctcaat gatacggaat tttccataag gtaagaggtc
    15721 ggcagaagta gaagcgacac cctcaatatc tgtacgaatt gtctttacca cttcgttttt
    15781 cttgtataac ttgccctcaa ccaataccgc attatcattt aaagaaatga tgtcaaatgc
    15841 agtatctttc aatgttgcac ttccttgtgg tttcgtatcg cccgtttcta aatctcgttt
    15901 ctgaattttc acaccgccac ggataacctt gtccgatacg gaaaactggt tacttccact
    15961 caatacggca aggtcgccgt cctcggtaat ctgtgttaca tataatccct ttatctgttc
    16021 ggacttatcc ccagcctgca tatatgcacc gtccagcaag tagccgtttg gagctttcgt
    16081 ttcctcaaca gttaatgtac caagtggaag aaccgcctta actccctgca tatagaagct
    16141 gtcgccagat accttgtatg cgtccgctaa ttttgtgatg tagtgggttg ccccgtcgct
    16201 gtctgtttcg gcgactgtct ttgtaaccca tgtacgagta gcttcggcag ggagattgtc
    16261 tttattgtag aaacctgcat aatacttcca tgtaaattcc gcacctgcta aagaagcgtt
    16321 tccctgcgga ttgtctttct gtgtttccat atcaattttg aaaagttcaa tcaaagtgtc
    16381 cgttactttt ggagtatcag atacgttcaa ggtcgctgtt tcgccagctt tgattgttaa
    16441 tggatagact gttttatcca ctttatatcc tgctggtgcg gataattcct tgatatagac
    16501 tgtgcctgct tttacctcta caacatctgt atttccgttt tcatcagtcg taagggtggc
    16561 aagttgtttc gtgcagtcct tatcagaaaa gacaccgtat gtcgcacctg caatagagta
    16621 attcccgtta ccgtctgtaa tgctggtatt attggaagtc ttttgaagtt tagcatttcc
    16681 gacattcagt ttcgcccaga attgtcccaa ttcctgcccc tcgccagagt agatataacc
    16741 gccacattca tagcgtcctt tattttcttt gacaaaggct cttgcaccag cgaaaacttc
    16801 gtcctgcgtt gcctttggaa tttcatcata agaagctctc acgttgtcgc attgccagcc
    16861 aagatgtacg ctcaatctct gccagactac aagctgtctt aaaaggtagg cgtgattgtt
    16921 gcttattccg ctgtggctgt ctgtgtactg tttcacatat tcgatagata aggcaacgtc
    16981 gcttatctgg tcggcactca tacgggtgct tgcgtcagtt ctgattttgt aaccattctt
    17041 aaaatctgtg ttaatgtcga tacagtaagc gtcctcgccc tcaacggtca aatgtccctc
    17101 attaaaggta gaaccaatcg aaccgtcatt cattactttt tcaacgatac cgacacgctc
    17161 ttttgactcc gtccaatatt gcttactttc tgcatgaacg ggtgtagtcg gtaaagcagt
    17221 aacgacagtt gcaagagcta agaagcccgt acacaatcgt tttaacatct ttttcataaa
    17281 tctaatgctc ctttcatttt gggtataaaa tagccgtcca ataagaacgg ctgaaaatag
    17341 aaaaggaacg tcatgttagg cgttccatag tctataagtt attcaatttt ttcttgtttc
    17401 aatactgatg tgctgtacca tatctttgcg tatctaggaa aacttgcgta tcaaggctca
    17461 ttcgttagta gtaaataagt agtaaattga tgtgtttgtt tccttgaaaa tgctgataga
    17521 tactgtgttt taggggataa tcagattttt attgtgtttt taaataaaaa aatcacttta
    17581 ttttataatt ttttatacca taaaaaatga gctatctcta tttgagataa ctcatttttg
    17641 attattaaaa aactaagcac tttgctcttc tttatttcct tttttactca ttccatcatt
    17701 tattttatct actactactg ctattgcatt atctcctgat acattacatg ctgtaccaaa
    17761 actgtcttga gttaagtata aagctatcat taaacttgca agcccaccat ctgatggtat
    17821 tccaaccatt ggtaggaaag gaagtgcact cattatagcc ccacctggtg ctcctggtgc
    17881 tgcaaccatt gctataccta acattgcaat ataagggaat aatacaccta ttccatgtgg
    17941 cataccattc atcattaaaa ctgcagttgt aaatcctgtt attgatatca tactacctga
    18001 taaatgtatt gttgcacaaa gaggtacaac aaattctctt atttgcttac ttactccatt
    18061 tttttctgca caaccaacat taactggtat agttgctgct gaagattgag ttcctatagc
    18121 tgttaaatat ccaggtactt gattttttaa cattcttact ggattttttc ctgaaaatac
    18181 acctgctgct gtgaattgac atgccatata tacaaaatgt aaaggtatta ctactaagta
    18241 tactttccag aataccccta atattgtcca tacttcccct gctatagtta tatttgcaaa
    18301 agttcctgct atgtataaag gtaataaagg tataatcact gttgacaacg ttttcgttac
    18361 gattccttga aattcttgga agaaattaaa taaagtctct ccttttccat gatttcttaa
    18421 agctgatatt ccaagtccca ttacaaatgc aaatacgatt gcagctgtta catctaccat
    18481 aggctctaat ggaattgtga atattggagc taacattcct gcctctgggt ctccaatttg
    18541 acttgcaaca cttgcatcaa taaaatttgg gaagattaat gtagatactg caaatgataa
    18601 taatcctgct attaaggtag aaccatatgc tattcccgta gttatcccca ataactttcc
    18661 tgcacctgtt gctaaatcag ctatacctgc tgttacaaaa cctataatta taaatggtat
    18721 aacaaatttt aggaatgctg agaataaagt actaactgtt actaatattt gtactattat
    18781 ttctggtgca taacttccga ttaaaatacc gactatgata ccgatgatta gtttgggcac
    18841 taaacctatt tttttcttca taatatttac cctccataac ttttttaaat taagcattct
    18901 tgcacattga atacttagtt aaatattgga tatccactta ttatgataat agagttttac
    18961 ctctccgtca acaatttaac cattttttgt taataaaaaa aagaataaca tatataaatt
    19021 gttattcttc ttcatctttt atagaaaatt ctacattttc aattatattt gaatgtttat
    19081 ctttttttgc gataactcta tacttattaa tttcttcatt cactatacct atactccaaa
    19141 ttaaaactat agcatcatct ataaaaccaa atgcccctgc aatcatctct ggaattatat
    19201 caaccccaga tacaaagtag gatatagtaa aaattaatac agaaattacc tttattttat
    19261 caactatatt gattctttta tctgtcataa aatcaggtag tttaagtaaa tcaaatacaa
    19321 aaaccaaacc aaatttagca tttttaaatc tgaccaaaat tttttttaaa atatctaaaa
    19381 ctatattaat gattattttt aaaaactcca tatttatcac ctcttataat tataggttat
    19441 tctacattat aaccgatata attaatttga tgaacatatt agatataaat tttatcaatt
    19501 agtttatatt taaattataa taattcaatt cctgcactac tacaattttg aatcatatcc
    19561 tgtggccata ctccaacttg tacttctcct atatgagctt tttgtaagaa atacatacat
    19621 attcttgact gaccaattcc tccaccaatt gtatacggaa gttcgccatt taaaagcatc
    19681 ttatgatagt caaactcttt tctctcttca catccagcaa gtttcaattg tctatcaaga
    19741 gattcttcat caactctaat tcccattgaa gataattcta atgctgaatc taaaacagga
    19801 ttgtaaaata atatatcccc attcaattcc caatcatcat aatcagggct tcttccatca
    19861 tgtttttctc ctgatattaa tgtttttcct atttgagtta taaatactgc tttcttctct
    19921 tttacaattt tatcttctct ttcctttggt gataattctg gatacatatc ttctaactct
    19981 tgtgatgtta taaaagttat ttcttctggt aatatttctt ttataccttc atacatacta
    20041 catacaaaaa tttcagtatc tttaaatact ccatacaatc tttttacaac atcttttaga
    20101 gtcttttcat ttctactact tttatctata accaattccc aatcccattg gtctacataa
    20161 agagaatgta tattgtctaa ttcttcattt tttcttattg cattcatatc tgtatataaa
    20221 ccactaccaa cttcaaaccc atatttttta agggctaatc ttttccattt tgcaagtgat
    20281 tgaacaattt ctgcattttt attcataaat ggtatatcaa agcttacagc cttttctcca
    20341 tttaaattat catttgcacc tgtttctggc aatacaaata acggagaaga aactcttata
    20401 agatttaatt cattacttag tctcatttca aaaaaatctt ttaatttttt tatagctatt
    20461 tgtgtatcaa ttacgttcaa actactttta taatcctttg gtattattgt gctcatatca
    20521 ttcactccct atatttatat atttttccat taaaaaaacc cttcatccct atataaaagg
    20581 gacgaaaggt tgcttttccg cggtaccacc ctgattagtt tgaaataaat tcaaacccag
    20641 ctcacaatgt acagatatta ctcgatacac cccaatatga taacggtttg gttccgacta
    20701 agcctactct tttaaaattt cggttagcaa ctccaggatg ttcttcatta tagacttcat
    20761 attggtctca caccatcacc aactcgcttt aattacattc tataactact cttcctttca
    20821 aagtctttaa gagtttaatt caataaaatt tagctctctt atgttttcta tttattcata
    20881 atagtatgat aagtgattag ttaaaatttg tcaagtttat tattttttta tttttaaaca
    20941 ctttataaat ttttacctat actttataaa ttttcaaata tagtctttaa tctgtccata
    21001 cattctttta ataaagactg tggacaagct acatttattc tttcaaatcc tattccttct
    21061 tttccaaata tataaccttc atcaaataat acattagctt ttttaaacat taaatcttca
    21121 agttctactt catttaatcc ataagcagta aaatctaacc atgctagata tgttccttct
    21181 ggataaacaa gttttacttt tggtaggttt tcttttaagt attcatcaat aaattgtata
    21241 ttattatcta agtaatcatt taattcatta agccagtctt cactttcatt atatgctgct
    21301 attgtagcta caatagcaaa gggatttggt gaagttgcaa ctccaacagc tgtaacctct
    21361 tcttgatatt tcttttttag ttcatcatta ttcactatta tattagacaa ctgcattcct
    21421 gccagattaa atgttttact tggagctata catgtaacta ttttatcctt gtactctggg
    21481 cataatgact gtaaaggagt atgtttaaat ccttttctaa ttaaatcaga atgtatctca
    21541 tcagctatta tccataggtc atatttttta catatttcta caaccttttt taattcatct
    21601 tctctccaaa ctcttccaac agggttgtga ggactacaaa gtatcagtac tttattgttg
    21661 ctacacttag ctttttcttc taaatcatca taatccatcc tataagtacc attctcatat
    21721 atcagaggat tgtttacaac atccctatta ttgctcttta tcttagcttc aaatgggtaa
    21781 tacactggtt tttggactat tacaccttca ttagaattag ttaatattct tactaaaata
    21841 gcaacagcag gtacaacacc aggactaaaa ataatatctt ttctatttat ttcccagtta
    21901 aatctccttt tataccaatc acaaactgca ttaaagtatt tatcactatc atttgaacta
    21961 tatccaaata ttttatgttc aactttttta cgtaatgctt ctattattgg ttctgcacat
    22021 tcaaaatcca tatcagcaat ccaaaaaggc aaaccatctt tttgtgcttt tgttgaacaa
    22081 ttagttctaa aatcccattt tacacaatct gttcctactc tatctattac tctgtcaaaa
    22141 ttatacttac tcattttttc cctcctaaga ataaaatttt tataattgtt aagtctatta
    22201 ctagatgcac tttggtatta ttttacaatt cttaatatta taataatatc acttttttgt
    22261 ccaatagatt taaaatataa ttacttttcc atcatatttt ttcaatattc caaaatcagt
    22321 ttcattatat caaaataaga ttgctcatat taattatttt ctaattaaca taagcaatct
    22381 ttttctataa cttctataat tataatttta aatgtagaat tattagtttg gatgttatcc
    22441 caatctcttt tcaaccaatc tacaccatat atctacacca tattctaaag ctttcgtatc
    22501 aaatgttaca tttggattat gaaatcctgg tgtagcatca gctcctaatc caatatatgt
    22561 agttttacat tttagttttt gtgtataata atggaaatct tctccaccag aatttttaaa
    22621 tatacctata gatgcatcag ctcccaatac atcttttata gtttcttcag ccaagtttac
    22681 aagttcttca tcaaattctg ctgctggtac tccatctttg gaaattagta cagcttctgc
    22741 atttatagaa cttacagcag tttttacagc atgtattgct ttttctttta attcttctat
    22801 tatatcatta ctttctgccc ttatatctaa agccataaat gcttcatctg gtatattatt
    22861 ataagtttct cccttaactg atatatttgt tacttttata gaatttggta tagctggatt
    22921 tactcttatt gcatttattg cattcactgc taaacagaca gcatctactg catttactcc
    22981 taaatgtggt ttagaaccat gacaagtgat acctttaatc gtaaattcca ttatacagct
    23041 agcacaatgg tacattgcag gtatcgcctt tcccaaccta caatcttgtc caggtcttaa
    23101 atgcatccct accatttctt ctacatcatc caacaaacca gaatcaatta ctcttaatgc
    23161 tccatataat ttttcttcac ctggttgaaa aagtattttt aacttacctc tttttactaa
    23221 atttctctct tttattaact ttgcagctgt taaaagcata gaagtatgac catcatgacc
    23281 acaagcatgt atcattttct tttctccatc tatgataaat tccaatgcat ccatatctgc
    23341 tcttatagca aatactggtc cttctttttt agaatctata gttactataa taccagttcc
    23401 tgcaattcct ttattaatat tttcaaaccc cattttttca agctctttta aaacaaactc
    23461 tgatgtctta tattcttcaa atcctttttc tggtatagtg tgtagataat catacacttt
    23521 atgtacatac tcaatatagt ctttgttagt ttccataatc tagctcctcc ttaaaattta
    23581 aactttccat ttatattaaa tctttattat aattacctat actacgaaat aattcattat
    23641 aagcattgca atacaaccat ttaaagttgc tataacaaac atatgtggat aatatttagt
    23701 ttttaactca gctgttccta aaagtctccc cataaattgt atctgcgctc ctgaaagcaa
    23761 taacattggc aatagaattg caacatgtgc ttgacttatt tgacctgctg taaataaacc
    23821 tgcgattact ccagatgctc ctcccattga tataaatatt gtcattatag ctgttgctgc
    23881 aacacctgga agtccaaaga tactcattac aggtgtaaat attgtcccta ttacatccaa
    23941 aagacctgtt aaattgaaca cagaaattat agcaaaaccg aagatgacat ttggagccat
    24001 tgaatttgta cttatttgga atccatttct agctcctcca ataaacgcat ctatcacatt
    24061 tcctttttta acttttactt ctttttttgc tacctcactc atgttaagct tcccccttgt
    24121 caaatttatt taaatataat ctaagtaagt tcgccccaac aaacttcata attaatatta
    24181 aagcaagtgg tataaatatt ggtacatctc ctataaatgg aaatagtgct gctccagaag
    24241 caaagaaatt cgtaattgca gacgcacctg aaaattgaaa tgcacaaaat acagcttttt
    24301 gtttttcatc tatataccca tcatctttaa gttctttagt catagatgca gctgcatctg
    24361 tagactgtaa actagctatc aaagttagtc ctgcaaatcc aggtaaccct aataatggct
    24421 ttaatagtgg actaagaagc ttttgagctg ccttcattcc atctaagtgg tctataactc
    24481 taactactcc aagtgcaaac ataactgatg gtattaatgt caatgcatat agccatccat
    24541 ctcgagggcc agtacctcca tcacctctaa agtttgcagc taatgtacct acaccatcat
    24601 taattgttcc caatgttcca aaagaaccta atacattgtt aaaatccaat acttttaatg
    24661 gtcctggtgc atctttaaat attcctgaaa aaaataatgc tcccaatatt aatgctacat
    24721 acccatacca ttttacctca actttttctg ttgttgattc taatttactc atataaattc
    24781 tccctcctgt ttaaatgaat tttattagta tacttgttta ataagcaaaa cttatgccaa
    24841 taccttaatg ataaagcctt tgtatttatt tttttattgt aaatttattc cagtgattaa
    24901 atagcttata attacttact tttcaagttt aaaaatataa tattttttta ttaattattt
    24961 aaaatataca ttacaatata aaaagctatt ttccttatct tgcaaaaata attttaaaat
    25021 aggtttttat aggataaaat cctaaaaaaa cctattattt aatcaaatat ataaatttat
    25081 actactattt gttgtataat ataacttgcc ttatacttta aatactttaa aaataaatac
    25141 tattttgtta ggagaaataa aatggataaa aagaagttaa tccttataac acatgataaa
    25201 ttgaatagtg accactacaa agaagaatta acaaactttt ttggagacga aataatcata
    25261 gaaacacaaa atatacttga tggaataaaa gaaaatttag agggagatgt agtgctttct
    25321 ctatcacctt taactagtaa ttttttaata aaacatttta aggaagatat tgaaattatt
    25381 catggaacga aagcactttc aaaacttgga tatgaaaaaa tgatgaaact acctccaggt
    25441 acaaaatcgt tacttatgac aaccaataaa acttcagcat ttgagatggc tacttatcta
    25501 tataaaattg gtataaatca tatagatttt gtaccgacat atccagattg tgatgaaata
    25561 tatgatttag atacagctat aacaccaggt cagattagat ttataccaaa atacataaaa
    25621 aatattgttg atttaggttg gagaaaaatc tcattagata catatatgtc attattagta
    25681 gtattaaaac taaaaaatga gaaatttata gaaaaactat acaaattgtc caaagagaca
    25741 ctaagtcatg atttcttaaa tacatcatta gataatatat ctaaattaaa aactatactt
    25801 tacatgacca ttgatgaaat aggtgatggt ctaatatttt tcaacacctt taacaaggtt
    25861 acttttgtaa ataagtcttt acttaatatg ttgggactag atgaaaaact tataaaatca
    25921 ccttccttaa tggaatatat gccaaatagt ttcttagata aaattacaaa gaacttaaat
    25981 atcgataata tgattatata catagacgaa atagataaaa aattcatact ttctaaaaaa
    26041 ccattttatc tttataaaaa tatagagggt tgcttaatta cattgaaaga tgtaaacaat
    26101 atagaaatat tagaacaaaa aataagaagt gattctgtca aaagaggtta tgtagctaaa
    26161 tataaattta ataatattat tggaaatagt tctattataa aagattgtat taaaaaggca
    26221 aaaaaaatgg ctcttacaga taatcctata ttaataacag gtgaaacagg aacaggtaaa
    26281 gaagccttta ctcagtcaat acacaatcat tcaaatagaa aaaataaacc ttttgtagca
    26341 ataaattgtg cttcattacc aagtgaatta cttgaaagtg aactatttgg atatgaagat
    26401 ggttctttta ctggagcaaa aaaaggtgga aaaaaaggat tattcgaatt agctcacact
    26461 ggcactatat ttttagatga gataggagat atgccacatg atttacaggt taaactttta
    26521 agagtcttac aagaaaaaga aattagaaaa attggtggta caagtattat tccaattgat
    26581 gtgagaatat tagctgccac aaataaagat ttagagaaat taattataga aaataaattt
    26641 aggatggatt tattttatag gataagtatg ttcactttag atttacctcc tcttagaaag
    26701 agattagaag atatacctct tcttttagaa tcatttttaa aagaacttcc ctataaaaac
    26761 ataaaactcg ataagagtct tttagaagct ttaaattcat acacttggat ggggaatatt
    26821 agagaactga gaaattgtat tgaatatatg gcttacatgg gttccaatta tcttacaata
    26881 aatgatttac ctcaaaacat atcttcaaaa ttaaataata atcatatgtc aagtaatatg
    26941 tccatattca atgatttaaa ccaatatgac aaaaacatat gcatttctat cctaaaatca
    27001 ttgcacatga aaccaatggg gaggacaaag ttaatgaaat ttatggaata taatgtcaca
    27061 gaatacgaag taagaaatat gctagaatat ttgacacgca atggatactt aatttctagt
    27121 aaaggaagaa aaggctcatc aataactgag aaaggcataa aaataataga aaataatata
    27181 atttaaacct atagtaattc atctttactt tatcaaaatt tatatataat tataattttt
    27241 tatttttcta taaatttttt ataaaataat aaaacttatt tatattaaaa acgaagctat
    27301 ctcaatatag ggataagctt ctttttaatt gttaaaaaga taaaaatata tttgatttaa
    27361 tagaaaaaga gtgcctcata aactaaaaag ttcattttga gacacttcct taatattaat
    27421 aaattaattg gcttaaaatt actgattgat aattataaag tacctctgtt aaaggagtaa
    27481 attctgaacc gattccaaat cttaattctg taaacgcctc taaataatct gggtcacata
    27541 catcttcttg tgttaaatct tgtttcacca tttcagtagc aagataaatt gctactgatg
    27601 gtagaaaagc atccattggc ataggatatc caccaagtct atttgacatg ccaaaagcct
    27661 tagccttttc acttatcatg tcgtttattt tatcataatt ttgagcatct ttttcagata
    27721 tttttagacc cataacacta ggatatgttt gtattggtga tggattgctt tgctctgcaa
    27781 ctatatactt taattctaaa gccttagtca atataacttc atccatatac tcatttacac
    27841 caaatacatt tatatctttt ccatattttt taacttgttt ttcaatatct tcatttaaaa
    27901 actgcttaac tttgtttttg tcttcttcag tatttatatt tggagtatta acttgtacaa
    27961 atggcaatcc tatatttttg caagtctctt taatcatttc taatcttttg gctatattaa
    28021 catctttcaa atcatctgta gaggcataat gaataaaagc ttttgctccc atttcttttg
    28081 aacgttcagc taatactttt cctctttcct ctgcactaac ccctagattc acatcaacaa
    28141 attggcttaa ttggttttta tcatctccca taggggcaga aatagttatt atttctggac
    28201 gcttttcctt taccttttgt aaagcaggta aaagccctgc ttggtcagtt gaaactacaa
    28261 tagcctgaac ttctttatcg tcagccaact ttactatctt attaatagca ctgtctatat
    28321 tagaagtaaa attctctggc aatacaacat gctttatagt ttgtttaact ttagtttgac
    28381 catctttgtc tttatcaatt ttattctctt cctcatattc ttttgccatc tcttccacca
    28441 tattgtattg tactttattt tcagataatg gttgagttac cactgcaact ttaaaatcat
    28501 ctataatttt ctctttatct ttcttgccta caagtaaact acaacctgta agtccaataa
    28561 ttaaacatat ggatagcata aatgctgtta tttttctaag cattaattaa aacctcctaa
    28621 atttgtacat tcttatcact attactaatt ttatcatact tcaaagaaaa attatattat
    28681 aaaaaattat atacatgcta ttataatcca atctaaaaag tactatgggt agattaggtt
    28741 tagattaaac ctacccatag tactaaaaat taatatatta taaaattaaa ttaattacaa
    28801 attattatgc tacttgtttg ttgcttttta taaagttacc aactattcca cccaatatag
    28861 ctggtattac ccagttaaag cccaaacctg caagtggcaa gctttgtata aatggaacag
    28921 ctcctgtcat tccatttata gctgataata aactaatcac taatgtaaca tatgctgcac
    28981 ctttaaaagc attatcattc tttatatgtt taccagccaa ctccataaca actattgcta
    29041 ataaaacagg atatatagtt tgtaggattg gaactgatat ggctattata gaatcaacac
    29101 ctaaatttga tataagcata ctagctacac atatacctat aaccagttgt ttataactcg
    29161 ccttacttat tccttcaaaa taagttgata ttgatgctgt taaacctgta gaagtagtca
    29221 gacaggcaag tgccacaatt acacctaaaa ttacctttcc tacttgacca tataacaata
    29281 tactagttat ttcaactaat aaagatgctt gaggtatact agtatcatat aaagttgaaa
    29341 ctgttgcacc taaataagta agaccaccat atactactgc tagaaataca caggctacaa
    29401 aaccagcttt aatagtcatt cctatttggt ctttatctga tgtatatcct ttagctatta
    29461 tagacatcaa cattatagtt gccatagatg ctgcacctag agcgtccatt gtttgataac
    29521 cttgtgatat accttcacca aatagatttt tatctatcat atgctcagga ctcataggtc
    29581 ctgctggaga aattataccc tttactatta aaacaaataa tactaataat aacgctggag
    29641 ttaaatactt acctattatg tctataacct tagaagacct aatagtaaat gctaaagtta
    29701 gcccaaagaa gattattgaa aatacagctt tagctactgg accatggtct ccaaatatag
    29761 gcataatacc catttcatat gttgttgcgc aagttcttgg tattacaaga agtgctaaac
    29821 atgctagagc agctacactc attactcttg ctaacccttt accagctctc ctaagtacat
    29881 catccatgct tcccttacat cttgctgttg ctataataac aagcattgct ataccagcat
    29941 ctgcaacaac aaatccaata agaggaatta accagtcttt gccggattcc atccctaaaa
    30001 atggaggaaa cataagattt cctgcaccaa agaacataga aaataaagca aaaccaacta
    30061 taaaaatatc tctcatctgc ttactcacac taaattaccc cctttgaaaa tattttgaat
    30121 attaagataa tcttacttta ttttcagaaa aatgtcaatc tggtaaaaat tcacacattg
    30181 ttaacgtttt cccaatttat tttatgaata tttttttcat tttatgataa ttcccatcaa
    30241 tttcgttaaa tcaattgctt gtgacacatc aaaaattgct cctctaatat catctatacc
    30301 aatctcaatt ccctcaatat tattagtagt aaaatctatg ccagaaagtt tagttccatt
    30361 aaagtttgct ttttttaaat ttgtatactc aaatactaga ttgtcacctt ttacttcttg
    30421 aaatacagaa ttttcaaaat ttgaatctaa gatagaaact atcttaaatt tagagaatga
    30481 aaagttagaa tacttaccta aaacatcctt gaacaaaacg tttttaagta tacaatcatc
    30541 aaatctaact cctatcaatt tactattttt aaattcaact ctgtatatac ttcctccatc
    30601 aaaaaatgta tttgataaat tgcagttttc aaataccaca tcaagtaaat caatcttttt
    30661 taaattacaa ttttcaaaag acacatttct aaatatacaa gattcaaagc taactcttac
    30721 agaatctaaa tcacttataa cttcattttc tataatttta ttaaatattt tttcatcatt
    30781 aaatatatct tcaagtatat cttcaagatt ttcaataatt tctaattctc ctgtaaattt
    30841 aggtttttgc actttaataa ttttagtcat tttcccctcc actataaatt atattatttt
    30901 tgatattatt ttttttaata tattaactta atatacatat ttgatatatt aaaaagtttt
    30961 tacgaaatat ccatgtattc agtactttta taattatatc acaaactcat ttataataaa
    31021 cttccattaa tagtataaaa caagttagaa taattgacat tatattcata catattcaat
    31081 tattggaaaa agtaattttt ttcaataaat aaccttaatt ttttataaaa tcgacaaaaa
    31141 aacgaataat tttattatat ttattgtaaa taatacaata ttacgatata atacaacaga
    31201 aaaacaaata gaaaatgttc atataatatt agtaatacgg tctaatagtt tctacaaact
    31261 caccttaaat gggttttcta tgaatagaat gtcaactctg aatatatgtt ctattctatc
    31321 tatatgaata tatatttttt tgtttatatc ttaaagtttt ttggaggtaa aaatggtacc
    31381 aaacactaac aatgtacaac caggtggaaa taattcatca ttaagctttt tagacaaaat
    31441 gtttaaattt agcgaacgtg gctctagcct taaaacagag gtaataggtg gagttactac
    31501 atttttaaca atggcataca tagttttcgt aaatccagca atattatctg aagctggaat
    31561 ggataaagcc gcccttataa cagttaccat actagctaca gccattggta cacttatatt
    31621 tgcgatttta ggaaatgcac catttgctct agctcctggt atgggattaa atgcattctt
    31681 cacatactct ttggttatag gtgcaggaat cccatggcaa acaggtcttg gggtagtttt
    31741 tctatctgga tgtgtcttct ttacactcgc agtaacaggt cttcgaaaga caattgcaga
    31801 cgcaattcct agagaattgg cagtagcatc ttcagcaggt ataggtcttt tccttgcttt
    31861 tgttggttta aaaaatatgg gtgttataat agctaatcca gatactatag tttcacttgc
    31921 agattttaca ccaacagttt taatagctct ttttgctctt atcttaatgg caatactaga
    31981 atataaaaaa gttaaaggtg gaatattgat aagtatagta gttgcaacaa taatatctgt
    32041 tatatttgga tttgtggagt tgccaacagc aataatctcg acacctccta gtatagcacc
    32101 agttgctttt aaattagata ttgtaggtgc attgaaattc tcattaattg gacctatatt
    32161 ctctttcatg tttatagaca tgtttgattc attagcattt cttattactt gttgtaaaca
    32221 aatgggtctt gaagatgaga atggtgaaat aaaagattta ggaagaatgt tatatgcaga
    32281 tgtttcttct actttaatag gctcattctt aggaactagt actgttacaa catttggaga
    32341 atctgcttct ggtattgcag caggtgcaag aacaggactt gcttcaatag taacagcagc
    32401 attattctta gctacactta tatttacacc attacttggt atagttccta cttacgctgc
    32461 agctcctgca cttgtaatgg ttggtgtatt catgtttgaa agcataaaac agattgattt
    32521 tgctgatagc aaaatagctg tacctgcttt tgttacagtt ttattgatgc ctttaactta
    32581 tagtataagt attggtttat gctttggatt tatttcatat ataataatgc atgtagtagc
    32641 taaagaaact gataaaatca gtattacact ttggattata ggtttacttg cagttgtaaa
    32701 cttagttcta agttaatatt tttaaatagt tctaggtcaa tattttaaat tatatagaat
    32761 aaaatcttat ttattttaaa tttataaata gcaaaatcac tttatatgta aattgatttt
    32821 gctattaact ttgtatagaa aatttattat cataatatat agatataaaa atatatagaa
    32881 aaggagtggt gtttatgtca caattactta taaaaaatgc atatctaatt actatgaatg
    32941 cagatagaga ggtatatgaa aatggaagca tacttattga aaataatatt ataaaagagg
    33001 ttggtaagtt tgatattaat attgtagata aagatgcaga gatatatgat gctaaaggaa
    33061 aaatactaat gccagggcta gtcaatactc atgttcactt atctcaacaa ttaggacgtg
    33121 gtcttgcaga tgatgttgta cttttaactt ggcttagaga aagaatttgg ccatacgaaa
    33181 gtagcttcaa ttatgaagat tccttgattt catctactgc atgttgtgtt gaattgataa
    33241 aatctggtgt cactacattt ttagaatctg gtggtcaata tgtagatgct atggttgaag
    33301 ctgttgataa aactggactt agagcctgtt tagctaaatc agttatggat acaggagatg
    33361 gtcttcctga ggcatggcaa aaaactactg atgaggaaat caacactcaa ttagacttat
    33421 tccataagtt taataataca tctaatgaga gaattaaaat atggtttgca ttaagaacta
    33481 tttttaatac aactgaagaa ttacttgtta gaactaaaga actagctgat aaatacaata
    33541 caggtataca tatgcatatt gctgaaatag ctgatgaaat ttcatttgta aagcaaaaca
    33601 atggagttgg aacagttgaa taccttgata aactaggtgt attaggacca aatcttttag
    33661 ctgctcatac agtttggctt actcataagg aaattgattt atttagatta catgatgtaa
    33721 aagtttctca tgacccaggt tcagctatga aagtggttct agggtttgca tcaattcctg
    33781 aaatgttaga aaaaggaata cctgtttcaa ttggtactga tggagctcct tcaaataata
    33841 gaatggacct tatgagggac atgtatctta catcactaat acataaagga agaactttaa
    33901 acccaactgt cgtaccagct gaagaagtct tagaaatggc tactataaat ggagcaaaat
    33961 gtgctttact agaaaaagaa attggtagtc ttgaagtagg aaaaaaagct gatatgatta
    34021 ttctaaatcc agatacaatt cattgtttac caatgcataa tccaattgga aatatagttt
    34081 attctatgac tagtgaaaat gtagactcta ctatttgtga tggtaaatgg ttgatgaagg
    34141 aaagaaaagt attagttgta gatgaatctg aattattaaa taaagttaaa aaacaagctt
    34201 ctaaaataaa agataaagca gaagttaaaa ttccatctaa atttaaaatt ataaaataac
    34261 ataaatttca attgttttgt aaatatgaat atataaatat atttatatac atcatatata
    34321 caaaacaatt gtttttttat tttatattca ttagcattgc tcataaaata caccataatt
    34381 ccagaaaaaa taaccaatca gttaggatta catcatctaa gcaatatata aacgtcttag
    34441 tttataagtt ttattctact cttatctaaa accatcttta aagagttttc aactgtttca
    34501 attacatctt tataactcaa gtacacattt gcgtagatac aatcttcata taaattatat
    34561 tcagttactc tacaatacag cagttttcct ccatctaata aattgctcaa aatatagttt
    34621 tcttttcttg ggacatagcc tatcacatat ccagtttcac caactatttt aatagctttt
    34681 tcatcatata gattatcttt ctctctagtt aaatagtata tcttactttt ctccaattct
    34741 ttttcaagat attctctatt tctaaacctt gaaccagcaa cagctattga agtcaaatag
    34801 atatccttac catgttcatc tacttttatt ttttcaatat ttacaaattc tttttttaaa
    34861 ttattacttt catataatac tcttcttaat tcatccttca atataacatt tttttctttt
    34921 tcatacgctt ctttaacaat ttttaattct tcaagagata gtttctctct gtatcttttt
    34981 aagatattta tggattcttt tcttacttca tttatatttc caaatattcc ttttaaagat
    35041 atattctttc cttcaggata tagtgattta cttcctttaa gcacaataaa aaataacata
    35101 tcatcataat attcttgagt caatttatct ttttctatat ctttcatttt tccaattaaa
    35161 tcatctattt taaacgtctc ttcaaaaaaa tttaataatt ttaatctaga acttgtcgtt
    35221 ccctttttag atatatgcca atatacctca aaatctctaa tatctctatt tagatatggc
    35281 aacaagtcat caaaagataa gtttacatca taaatttctg acatttttat aatatcttct
    35341 gtttttccac tagcatctct taatgcttca aaatatatat ttttccattt ttcactgagc
    35401 aagataccat ttatttcttt ttcaaattca atcttattgc actctatatt ttcatctttt
    35461 aagacgttta tagctattag gaaaattgaa tataaacttt caaagttagt cccataattt
    35521 actacagtag gtaaaaatcg attcactaat tctaatttat tacctatata tttaaattct
    35581 acacttagca agtaattgca tataagacgt gctaaattat ttatcttttc tttatctaaa
    35641 tctcgttttt caagatattc attcaaatct acaattgaaa taatatagtt catcaataat
    35701 cgttcgtact ttgtatcctt ataaccatct tcaattagat aggaatttat tttagaatct
    35761 aaattttcca tattaacaat agcaaatact tttattgaac ctgtagcctt tttagataaa
    35821 ttaaataaat atgtattgta aaattcaagt tttttaatag tattactcag ataaaatacg
    35881 tattctccag atttagaaaa tgtatctaca acttctctta agttttctac atttagatat
    35941 ttctcactta aaactaaccc tagttttaca tactcaactt ttttactctt atatattaat
    36001 tctttagtta atttatataa ccatttctca tcaataatca tttcttttac caaagtattt
    36061 atctttttca taaaaatttc gaaataacaa attaaagact tagaattact accctccaat
    36121 aaataaattt cattagattc acttttatac atatttaaaa tttcatctac tagattattt
    36181 gcaagctcta cttgttctct taacggtata ctttcatata tacataggta attcatttca
    36241 aatgattctt tgtatccatc ataaccatta aattcctgca atcgcttaaa aacattctcc
    36301 accaaattat cctcctttac atgatgtaat ttatattgat tatactactt atttcatcaa
    36361 gtttacattt atacgcaaaa aaatattact agaaattgaa attctagtaa tatccttatt
    36421 attaattatg taaataccct atcttataac tgtaaataat atccttatta attttaatta
    36481 cttttaataa aaatctatcc tagatttaga cttctctatg catatattat actaatatta
    36541 gacatcataa tcatacactt tttctttttc atatctcatg tttacaaaca atgcaagtaa
    36601 aattccaaca aatgttattg ccacattaaa caatacaaca tattttggtc cattaactcc
    36661 ccctgatttt gtaataatac ctgctatatt taaaataaca tagtttgcta tactagatgc
    36721 aatcataact atagatgtta tttttccttt attagttgga aacatttcat ttgcagttga
    36781 cgttgttaac tgaagaacac ctcctgctgc tgaataacct attacaaatc cccctaacat
    36841 acaaatagtt ggagtttgaa caaaatatac aactaatagc ataagtaaag ctattatagg
    36901 atatataact aatattctta ttggtttaat atatttttta ataagtaaag aagttattaa
    36961 tactgcacat attactccca ttgagtaaaa ggattgaatt tttgtagggt cagccatccc
    37021 atacaattta cccaattcct gattacaatt taaccataat acaaatgtag atgtacatgt
    37081 aaatccaata caaacaagag ctatacttgt tggtgtaaat ttcatcttct ctgatttaac
    37141 tgttttgcct ttgttatcaa taacattatt agctggtgga aatggtaaca cagctatcaa
    37201 aaaggcatct actacaataa gaatcgctgt tactataaaa ataactttaa atgatattga
    37261 atttgctgca acaaatccaa ttataaaagg aagcaaaaat tgtgctaaag ctattgtaaa
    37321 tttagtaaac atatttgcta ttgttcctaa actagcaaat atctccatac aagaaggagt
    37381 tacacaggta tctaagaatg aatttgctgc ccctccaatt attgcaaata catatgctat
    37441 ataaaaattt ggtgaaaata caattccaac aaagaaaatt gcatgtagaa agtttcctat
    37501 aagaccactt acttttcttc catacttatc tgaaataggt cctgcaaatg gataagatat
    37561 aagtctccct aatcctagtg cagcaataac agctaaaaca atacttacat ccaatgttcc
    37621 atctgataat gttttagccc cccacattga tgaaaattct ggtttgtatt gtcctaaaat
    37681 tgaaattcca ataccaagta aaaaatatga aaaatacaac gctatggcag taggataata
    37741 ttttttattg ttcataattt ttctcccatt cttgttaatt tattaacatt tttgtgtaca
    37801 ataaactcat ccccataatg gatttaaagt atagtcagtt aaaacttcaa atttaactgg
    37861 actatgaggc aaaacccact atgacaattt gtaatttatt attaaaaata ttgaaatacg
    37921 tatgtttttt cattgtttaa gatattactc ttatctattt aaagcataat tcattaactt
    37981 cttctacagg catttctaat ccagtatata gattaaaagc ttctgctcct tggtataata
    38041 acattcctaa tccaccaata gccttacatc cattagcttc agcatcttca atcatttttg
    38101 ttttcttagg attataaacg acatctgtta ctactaaatc ttttcttaaa acactagtat
    38161 cttttatatt tgtttcattg tcataaggct tcataccaat aagagttgca tttgtcaata
    38221 tatcacttga ttgtatctcc tcataaagtt tgtttgtatc ttctaaatca tatagattaa
    38281 caacacattc tggtacatct ttttttatat tctcaactgt ttgctctgct cttttataaa
    38341 aatcatcctt aggattaaag atagatattt ctcttgctcc atctaaagca cattgtactt
    38401 gtatagcagt tgctgcacca ccagcaccca taattgtaat ctttttacct ttaacttcta
    38461 ccccattttc ttttaaatta cgaacatagc ctactccatc tgttatatga ccaactaact
    38521 ttccattgtc atttacaatt gtattacatg ctccaattat acgagctgct ggagaaagtt
    38581 catccatata ttctgtaaca gcagatttac atggcatagt aacattggct ccttttatat
    38641 taaaagtttt tattgctaaa agtgcctctt ttaccttatc tactgtgata tcaaaggcta
    38701 aatatctata atctaaatct aatttcttaa aactataatt atacatcact ggtgatttag
    38761 agtgaccaac cggtgtacct attaatgcaa ataatcctgt tctacctgaa atttccataa
    38821 ctataatctc ctctcaatat tatcattttc tttgcaaata acctattcag ttatttacaa
    38881 agaaaaattt atttattatt tatatattta atgctacttc aaaagcttct tttgttgcat
    38941 ctaatgccct acgagctttt actgcatcac caacaatata agtttctttt acaacttctt
    39001 ttataacttc acttaatggg tcgtaattac gagaacccat agcaagtact actgaatcaa
    39061 aaccttttaa atcatgctct gtgccatctg taagtaaata gtcgacacca tcatcataaa
    39121 atttagaaac ttttgcacca gtaatggtat gtatattata attttcaaaa tcattcataa
    39181 ggaatttacg gtgttctgaa attacatctg caccaacttc ttctctaagc tcaataacag
    39241 taacctcatg ttcttgttct ccaaggaagg ctgccacttc acatccaacc attccacctc
    39301 caacaacaag tacttttttc ccacaagatt ttttaccatc aagaaggtct acagcatgaa
    39361 ttaatcctga atcattgatt cctggtatag gaagtacaag tggagttgct ccagtagcta
    39421 taataactac atcaggtgat ttctccttta taagttctac tgtagcttct gtattagtac
    39481 atatttttac accatattga ttacattttg aaatataact tctaactaag ttagtaatat
    39541 ctcctttccc tggaggatat gcagctaaac gcatttgccc accaagaact tcagattttt
    39601 caactaaagt tacattatgt cctcttttag cacataccca tgctgcaagc atacctccaa
    39661 cacctccacc aacaacaaga acttctttgc taatttcagc tggcttaagc tctgcttcat
    39721 gtcctaatat aggatttgca agacaggcta taggtttgcc ttggaacata tttggtacac
    39781 atccttgtaa gcatgcaata catggtatca tttcgtctag ttttccattt ttagctttat
    39841 taggcatttc tgggtcagcc aagctttgtc taccgaatgc tactaaatca catcttcctt
    39901 gtctgaccat taactcagca aactgtggct ctgtataacg tccaactgtt attactggta
    39961 tactaacagc tttttttatt tcagtaacta attctgcact gaatccagca tgtaaagtcg
    40021 taggagccca catatattca tcatgtatat gtatactacg tgaaacatga agtccatcta
    40081 ttccacaatc ttctagatat gctgctatta ctgaactatc gtgtacatca attcctcctg
    40141 gaacatcatc agtgctgttt atacgacata atattgctag agaatttcct acttttttac
    40201 gtatattttc aatgataaga cgaggtaatc tcattctatt ttcaaaacat ccaccaaact
    40261 catctacacg cttatttgtt ctttgtgata taaaactact aaccagatat ccatgagcgc
    40321 agtgaacttc aacagcatct gcaccagctt tttgtgcacg taatgcagca tctccataag
    40381 attctataag ttcatatatt tcttctgttg ttattgctag tggtgtatta cgaccatttg
    40441 atgcaggtat tgcagaagca gcttttaatg gatgtcctgc tactttttca tttccttcag
    40501 aaccagcatg ttgtaattgt atagatacct tcgaacctgc atcatgacaa gcatctatta
    40561 catttttaaa actatctatt gtgctatcat catataaaca aggcttacga ggacctcctt
    40621 ttgctttttt gtctacaaca ctagattcta tagttattaa tccaaaacca cctaaagcac
    40681 gctcaagata ataagcctta gaagtttcac ttaaagtacc atctgtgttt gcaaaattgt
    40741 ttcccatagg gggaactaca aaacgatttg gaactgtcat tgaaccaatt cttataggtg
    40801 taaacataga actaatcttc ataaggtttt ccttcctttc aagttttata ttataatact
    40861 ctgtatattt ttatattata taagtttatt ttggagatac ttcagaccat gctttatcca
    40921 aaactttttt agttgcatta aatacagttt cagcagcagt ggataaccct ttagatatta
    40981 gagaatcaga tattacttct gcccctatga ctcttggtga tatattgtgt tcttttatta
    41041 ttttcacaaa ttcctctgtg tttccatatc cttcacctgg agccaaacgg tcatgtagtg
    41101 attcatccct aagtttttca taaggagttt ctaaaacatc acacacttga attgatacta
    41161 tcttatctgc tggaacaggt gcaaggtcct ctgctgtctg ctttgctcta gcccagtgcc
    41221 aagtatctaa tataagcatt gcattttcac gattacatcc tttcacaaca cgccatgcag
    41281 tagccaaatc tggtacacca ctatatggca taaactcaag acctataata agttcacctg
    41341 ctctgtcaca taattctccc aatgcagtta taatttgttc ttctggtatc atctctaata
    41401 atccacaatt tatatgttta acattaaata agtgagccat atgataaaca ttttgctctt
    41461 tttctctttg agcttccgtt ctatcttctt ctcttcccca ttgagttata tattctactt
    41521 ctgtaacttt catatcatat tcattaagaa ttgcaatcat ttcttcatct gtaacacctg
    41581 cattttttgc atcaatataa ttttcagcac gcaatccaat accatcaaac ccagcttctt
    41641 ttgcaatacg aactctatca cggaatgaaa cttctgttcc caatgtataa gaactaattg
    41701 taattggaat attaagattt ttttgattat tcatagctta aatttgcccc ctttattttc
    41761 tttataatta atagtatttt tgattttata tttttattta tcctactagt agtattattt
    41821 taccttaaaa ataaaagtat tttttgattt ctatttatct agattttata aatttattgt
    41881 atcacgagac tttactaata acaaattgat aatttcctat taattcatag attttgttta
    41941 tagattttat ttataagata attcttgtat ttttctatta ggtcgtataa atatatttat
    42001 cttataattc agacaaaaaa cgataaattt ttttaaaagc ttttattctt actctataat
    42061 catatataat aaaaatgtaa aaatatctta aaggttaact tctacaaata tataaataaa
    42121 aatacctatg aaaggatgaa caaaaattga atttatatca cttacgctat tttgttacat
    42181 tggcacattt agaacactat acaaaagcgg cagaaaattt atctataaca caaccaagct
    42241 taagtcatgc tatttcttta ctagaaaatg aacttggggt ggctctattt gaaaaagaag
    42301 gtagaaatat agtccttact aagtatggaa aaatattttt aaaagatgtg gaaaaatcat
    42361 tagaaatttt agattcaagt gtaaaatcat taaaaataac tggtactggt gaaggacaaa
    42421 tagacttagc ttttcttaga acacttggta ctgattttat cccagacata gtgcacaaat
    42481 ttttaaaatc taatcctgct aaatcaatag attttaaatt tcatactggt gtaactactg
    42541 acattattca aggtcttaaa gaaagaaaat atgatattgc attttgttcg aaacttgaaa
    42601 aagaaaaggg aattgaattt atacctgttg ccaaacaaga tttagtacta attgtaccat
    42661 atagtcatcc actagctgca aaggatacta tagatttaaa agaaaccata ccttatcctc
    42721 aaatagtatt taatcagaga agtggtctta gatatataat tgatgatatg tttaaaaaaa
    42781 taaatcaaca gcctaatata gtctatgaag tagaggaaga ccaagtaatt gctggattag
    42841 ttgcaaaaaa tttcggaatt gctgtagtcc caaatatgaa tatgcttagc tttacaaaag
    42901 taaaagtaat tcagattatt cacccaagtt gggaaagaaa cttttactta gcatttataa
    42961 aagatagata tttgcctcct gcaattaaaa actttaaaaa ctttgtcatt aaaaacgctc
    43021 aattataatt tattaataaa ggggttattt ttaaatatcc tcttttattc tttttataaa
    43081 ataaaaaaat ctatactttt aaaagtatag attcctaact gacagtcggc atccgagtct
    43141 cagtaattat cgttatacaa cagcaactgg attcagttcc tgaataacta ggttacttac
    43201 attatatcag attttttaaa atttgtcaat tgtatctaac gcattttttc aagccatggt
    43261 ccaacaggct ctacaatagg aacttcttta aatccccaat ttcttatatc attcacactc
    43321 gttggagtat atattttgtt tctgacagat ttgaatattt tgtttttttc tccatattgc
    43381 atacactttg gattagcttc tattaaccct cttcttgctc tgctaagagg attacataaa
    43441 atatctgcta tttctaaacc ttctctatag tcagcatctt cttttttggc aattataaaa
    43501 cccttaacct tatctcttaa ttcttcatct atatctaagt atattgttcc attattaaat
    43561 acatcaaaaa acgccttttg tacttttaag tttgagacat catcccttga ctctataact
    43621 attcgtgcag attctacagt ttcattattt acaaatgaat aaaaattctg aagaacatgt
    43681 ataaaagcca caacatacgg ttcctttgaa ggtgcataat atttctttaa tctagcttta
    43741 tctactgtta ctgatattat agtacactct aatctagata gaaataaagg caactcatca
    43801 tagaataact taatctgtga atcatcaaac ttctcaaatg ctcttgattt tcttgatata
    43861 tctgtcaaat gtattcctat gttactggtt ccaaaacaat actctttaaa tgcatccatt
    43921 tctttcctca aagaacatac ataatcgcct tgacttactg catatttata ttcaaaaatt
    43981 actcctgtca atgtaaatgg gtcttcatga tttatatcag ctcttccact ttcatcaata
    44041 aacattatat attttttctt tataatctta ctcaccctct taacatatga tgatagcatc
    44101 tatattcatt ttatatgagt tttaaaaata ttccaagatt tttatataac ttaaacttaa
    44161 ttttatacta aaaaattgag atgtaaaaca atcaagcttt tattgattga atttcacatc
    44221 tcaattataa ttatttttca atatatattt ttactatttt gcaagaatat ccattaattt
    44281 atccattact atataagata ctccgcctcc tatttgataa ggagtttcaa cttttttatt
    44341 tgcaaatact ctttgttgct ctgatgataa tcctgaatta tccattaaaa ctattggtga
    44401 atgtaatttt acagctaatg gtccagctga taaagcatct actaaagcat ctgatttact
    44461 aactaataca gcctgtaaat cagtatctcc atagaatttt tctatcactt tggcattagt
    44521 atctactcta ctatctccat atattctatt tcctgaaata tcttcagtag ttatatcatt
    44581 catttttgct attactgaat cgttaattgc acttggtcca cctataaagt atgcattttc
    44641 taattttctt tctgttagcc atttataaga ttcttctgta attccatctt tattgactaa
    44701 tattataggt tgtttttctt ccccagcttt agaagctaca gataaagcat ctgcctcccc
    44761 atttccagaa accatatatg cagtttttat ttcttctcga tttccaagtt cttcagctat
    44821 tcttgtagca gtttgatatc tatcttgacc tgctattctc tttgtttctg tgttgaaagt
    44881 agtttttatt tcttgctcta atttagaact tattgcattt tctccaccta tcaagattac
    44941 tgttttaggt gctaataact tcatttcttc aacagtttca gttggtaaat tagctgtatt
    45001 agtaagtagt attgttgagt catagctact tgctaaagga gttgctgtta taccatcagc
    45061 tattgcatta ccatttacta atattacagt atctgaacta tcagcattcc agtttccaac
    45121 tgaacttatc tttttagctg tatcaaatct atttgcacct ataattgtat cccatgtagg
    45181 atttatagtt ccatcttcat taaaagtata atctttccca tctatttttt gagaaccagt
    45241 tagcatcttt ccatctttgt ctaaatagta agacttacca tctatttgtt gccatcctgt
    45301 ctgcattatt cctgttttgt caaagtaata cttattacca tctatttctt gccatcctgt
    45361 tactgctaaa ccatcagatc ctagatagta tttctttcca ttcttttctt gccatcctgt
    45421 ttgcattact ccatctgagt taaagtaata agtttttccg tctattactt tccatccaga
    45481 tactcttgct ccatcagttc ctaaataata ttttttgtta ttaattgttt tccatcctgt
    45541 ttgcattact cctgaagcat caaagtaata catttttcca tttactttta gccaactatt
    45601 cttttggtat gttccatcag attttacata atacttctta ccattttctg ttttccatcc
    45661 tgtttgattt agatttatct tatattttgc cgctatcttt acatagctgt cgttactata
    45721 atctataatt acatctgaac ctacaggaac ttggtcaaat aaccatctaa catctttatt
    45781 gtgcattctt atacatccac cagaaatatg ctttcctata gaactctcat tattatttcc
    45841 atgtattcca tatgtatctc cataagttcc ttttaatgct aatcccatcc atctatctcc
    45901 taatggattt cttggacttc ctccaggtat attaccttta taatatggtc tattttttat
    45961 cttgttaact acttttgttt tccctgttgg tgtttctgac ccctttttac ctgttgcaac
    46021 tctaaattct tttacaagtt tattatttac aaaatatcct agagtatttt ttcttgaatt
    46081 tactataatc acatgtttac tggctgcgct tgattctggt acgccacatg caaatactaa
    46141 aactaaagtc agtgctagta ctaaatactt ttttagactt tttttcacta taacttcccc
    46201 ctcttttaga aacattacta catgtgtcta attataacat aaaattacca ataccttata
    46261 tttacaaatt tgttacattt atacatataa gtatgtattc tactcttcat acccattagg
    46321 attcatactt tgccatctcc atgaatcttc acacatctct tcaagttcat acttagcttt
    46381 ccatccaagc tctttttctg cctttgaaga atctgcataa cacatggcta catctccagc
    46441 ccttcttcct acaatcttat atggtatttc ttttccactt gctttagaaa atgcttttac
    46501 taaatcaaga acactatacc cctttccagt tcctaaatta taaacaacaa gtcctggatt
    46561 ttcttctaat ttttgtaatg cttttacatg accagcagct aaatctaata catgtatata
    46621 gtctctaact ccagttccat catgtgttgg atagtcatta ccataaacac tcaattcctt
    46681 caatttacct actgctattt ttgttatata aggcattaga ttgctcggaa ctccatttgg
    46741 ttcttcacct attctaccac ttttatgagc accgactgga ttaaagtatc ttaaaagagc
    46801 tatatccaat gacttatctg cttttgatat atctactaac atctgctcta tcataagttt
    46861 agttcttcca tatggattgg ttacagaaag tggaaaatcc tctaatatag gacaagtatg
    46921 tgggtctcca tatacagtag ctgaagaact aaatacaaac tttttaacac catattctct
    46981 cattaattca aataaattta aggtacttat tagattattg ctgtaatatt caattggttt
    47041 ttctactgat tcaccaactg cttttaaagc tgcaaagtgt ataattgatt caatattatt
    47101 ttctttaaat acaacatgca tttcatcttt atttctgata tcaatattat aaaattttac
    47161 tggtttttta gataattcct tgattctatc aaccactatt gagttgctat tacttaagtt
    47221 atcaactata acaacttcat aacctgattc taaaagttct attgctgtat ggcttcctat
    47281 atatcctgct cctccagcta ctaaaactgc cattgtaatt acctcttttc taatatttat
    47341 ttttcactta ctttttttct catatagtcc attaaatcat cttttaaatt ttctctcttt
    47401 agagcaaagt ctattgttgc ctctaaaaaa ccaattttat ctcccacatc atatcttcta
    47461 ccttcaaagt tataagcata aatagcctct tgttttccaa gagtttgaag tgcatctgtc
    47521 agttgtatct ctccaccttt accaggtgtc tgtttctcta atatgctaaa tattgcagga
    47581 gttattatat atcttccaag tatagctata tcagatggag cttcttcaat tgcaggtttt
    47641 tcaaccatat ctttaacttt atatactcta tcttcgatat gttttacatc caatatacca
    47701 tatttattag tatcttcttt agctatcttt tgaacaccta atacagttgt tttatactca
    47761 ttataagtat ctattaattg ttttaagcac ggaacatctg aatctactat atcatcacct
    47821 aataatacgg caaaaggttc atcacctata aaactttttg cacagtaaat tgcatgtcca
    47881 agaccttttg gctctttttg tcttatataa tgaatattta ccatatttga tatgtctctt
    47941 accatttcta acatctctgt cttacctttt tgctctagtt ctaactctaa ttcaactgat
    48001 ttatcaaaat gatcttctat agatttttta tttctacctg ttattataag aatttcttca
    48061 attcccgatt ctatagcttc ttctattata tactgtaaag ttggtttatc tactatagga
    48121 agcatttctt tgggctgtga ttttgttgct ggtaaaaatc tagttcctag ccctgctgct
    48181 ggtattattg cttttttaac tgtcatctgc attttttcac ccttcttcgt aaattttcta
    48241 ttgtaccaaa ttaatatacc atatttatac tttttcttca aactctatat tatcccaata
    48301 tttaatgcta taagataata taaggtagat gaaatttcat ctacctttag ttttataagt
    48361 taatattgta ttgtttatat tttatccaaa acttatacag gtactaaatt tcatctaaga
    48421 tgccttttat atcactatct atatcttcat ctagataaga atctaaatct tctaagtcaa
    48481 cttctagttc ttgatatgtc atatcaacac tgacatcctc atctatatcc atttctgata
    48541 ttaattctcc taaaatacta tttccatcag aatctaaacc actatctata tcttcatcta
    48601 tatagttttc atttaaaatt tcatctaaat caatctcgta ataaacttca ttattttttt
    48661 catcccctga gtccaatcct aagaactcat agttaaaagt ccaaacattg tatttacttg
    48721 acatacttta ttcctcctgt gaaaaacata ttttcatcta gtttattggt tccataatca
    48781 acagagttat atattttttc aattatgtct tttcttcttt cttttgtact attatttaat
    48841 gtcaattgtt taaatacata tgtatttgtt attctctcga ataatatttc ttttatacta
    48901 tcatcatcaa tatttctata gtttttccac aataactcaa ataacttaaa catttcccta
    48961 ctagtttcat ctacataata aggatacata ttttctacta aatggtttaa tcttgatatg
    49021 gcttgtttta aaaatacatc aagacttgca ctttcacttt cttttaacat tctataattg
    49081 tatttcttct tatcttctcc tgaaattaca aagatgatat tgtctaaact tttttcaact
    49141 tcatttaaat aactgcttat attatatgat aaatcagaca atagattttt aatctgctta
    49201 aacacttgta catcaagttt agtattatac ttttcaaaca aatctatttc ttgattttct
    49261 aatattcttg gcatatatgc tgacaataaa tctaaattgt ttctttgttc ttgtatttgc
    49321 ttataaagtg aatttataac ttctattctt atttcatcat ttaactcttt ttctaaaatc
    49381 ttatcaaatt cagatttcat atagtaaata tttccaaaga aattaaatat tatcatatca
    49441 ttcatagctt tagaccaatt cttatatatc acttcaatag aattttcttt aagtagaggt
    49501 tgctttgcat atataaatac atcttgcata agtttttgaa ccatactttt acttaagttt
    49561 aaaagtactt tttgattatt aaattttatt tccgtttcta caaaattaga attttcgttt
    49621 tcaagttctt tattaattac aatgtctttt atatcactat tttttataga tatgatttct
    49681 ttttgaaaag actttagaat agtcaagcta tcgaaatctt cttgaataaa aaatggagca
    49741 tgttttaatg tatatcccac tatttcattt tctatatctt ttaggtcatc tatttgcata
    49801 atttctctat ttttatcatt tatatgtagg ttaaatacat ttttattatc atataatatt
    49861 atatcttctc ctaaatttaa cttagaacaa ttatctttcg ctgactttac aatagtcttc
    49921 ttagatttct tatttataaa aattaattgg tcttgatatt ttactaaaag catgtttgtg
    49981 tttttataat caaatccatc tatatttcct gatatcttgc agaatactat ttcacaatct
    50041 ttaggaagat ttcctatttt ttggttatct ttaactctct catttaaatc agatgggact
    50101 acactatcta tattgttatt aaatatagat acagacctta ctataatccc ctctctttcc
    50161 atatgaaagt atcccttcaa tgacactctt ttatcttcta aaatgtatct ttctatatca
    50221 tcaaaattta tttcaaatct atttttccca ctgataaata taaacttctc attatcttta
    50281 ttaattccac ccatataaaa cttattgtca tctaaactta atatagtcat attatccttt
    50341 agatagaata taaattctct ttgacttttg cagattaaat catattcatc caaagttatt
    50401 ttcatagtca aatttgctgt aacattttta cttgaatttt cactttttat gtaaaaaggc
    50461 aagttatttc catagacaat tatttgagaa tcttctaaaa ctgcctctaa tttttcttta
    50521 ttgtctgaaa aactatatat atattttaca cctgtatcct cattaacttc atctgatttg
    50581 ctgattatta tattccctag atttgttata tgaagctttt tatattcttt tgagtatcta
    50641 cttatgccac taagctcaaa cccatctgaa agctcatata tgattttttc tcctaatttc
    50701 aacatacctt caccacctaa acagaattat aagtatttta taaaggtgaa taaaatgtct
    50761 caaaacaaat aatatttttt ttaatacttt ttattctgag acatagtttc tcctttttta
    50821 taatgctcta agcaccttca actatttctt cataaagttt atctaaatgt ttaacatatt
    50881 cacgatatcc agatttgttc tttaactcac ttcttaaatc ttcatatttt tgtttaagtt
    50941 cttcagcact caaagaagga gctgattctt ttaattcttc taacttataa tcatagtact
    51001 tatcatacat agctatatat gtatcaatag acttcttagc tagttcatta catttttctt
    51061 gtgcttctcc atattgagaa taatcaccta tttttatttt atagtatcca ttttcttgaa
    51121 ttattgttga agaaatacct ttagcttcat attcttttgc tgtttctttt gctgtttttt
    51181 caactttaag tgaacctgca taaacagtgt aatatacacc tttaccatct ttatatgctt
    51241 ccatttcttt tgctttcttt tcagcttgtg ctttttcttg agcctctttt tcagcttttg
    51301 ccttttcttc tgcttctttt ttctcttttt cagcttgtgc ttttttctct tcttcagtta
    51361 atttattgtt agcttgttgt tgagttgatg actttggaat attctcttta tcatttttct
    51421 tattgttgcc tactgttata aaatatccta caccaacaat aaccactata actactgcta
    51481 taatagtttc ttttaatcta ctcttcttag aaacaacctc ttcatcatct aaagaatctt
    51541 ctttatctga tacataattt ttcatttctt tcttgttttc tctatatttg tccttagaag
    51601 aatttttaga ttttttatta ctattttctt tctttttaat aggtattact actgattttt
    51661 cattttctaa tttttcttct tttatttctt ttgctttttt atcttctaag tttttacttt
    51721 ctttttcaag cttcgattca ttatttgaag atactttttc atctaagtta ttatttattg
    51781 gtttttctat ttttacacta cgttcttctt ctatatgttg acttggttct tcttgtttta
    51841 tttctttcaa ttcattttgc tctatttctt ctgatttcac ttgatgattt tcaactggtt
    51901 tatctaaaat tatatctgga gaaatatcat ttaaattctc ttcttcttgt tcagcttctt
    51961 cattgtcttt tttaataaat ccaaataatt tagccttctt tttactcttt ttattttctg
    52021 gttcaattat atcttcttta ttgctgtcgt actctttatc tgtagtatct ttatcttcta
    52081 caacgtcacc tatatcttga ttattactat ctacttcttc tttagtccct tcttcagcat
    52141 catcttctat tgaaatacta cttctaaagc aaatatcttt atctgcattt tttatcatgt
    52201 aaatgtattc ttcaatatcg atatctttat ttcttctagt tctttttgat gcaatttcat
    52261 gattttctaa ttcactatag ttatctttta ttagattctg tgctttattc catgtatctt
    52321 cactaatttc tgttttattt ttaattacat agtccacaaa ttccttaaaa ttttcaggac
    52381 caaattctcc aattatagtc agtctcattg caccttctat aaggtctcta tttcttctct
    52441 ttaaaaattc taatacaact gttgcacaag caaaatcttt aataatttct ttgccaaaac
    52501 catatgcttc aacagaatga agttcttcta atccacataa cttcttatat tcattgtgta
    52561 ttgtttgaga tatactttca ttatttaagc tatttaactt atctataaac ttcgattcta
    52621 tatcatttga ttttgattca tgttttactt ttgaattttt aatttcattt agtagcatgt
    52681 cattttctga attatcttta cctaattgca aatcctcaat ttcagttgct tttatttcta
    52741 ctttgttttg ttcgttattc tcttccacat tattaggtac cacatcttta ttactagcta
    52801 atattttgtt tacacagaat ataatttctc tttttaattc tcttttcgca tctgcttgat
    52861 ttttaagaaa taaatctcca cattctttct tttctaaact tatttttcta agagatatat
    52921 taagaaggtc tttatatagg tttaaaacct tataatcctt ttctaaacgt cttcttctct
    52981 ctgatagttc cattttatca taagctaaaa aactatttaa atcattggct tttagagagt
    53041 ctaatccctc tttcatagcc ttatttacat actttctaca ttttgctgta gttaactcta
    53101 aatctttttc taattcatct atttcaggta tgtacttatc tactatccat ttgccaataa
    53161 gtggttctgt atttcttgct aatgtcttat aaaacaatat attaaatttt aaaagctctg
    53221 catattttgc ttcattaaat tctacttttt caaatttctt ttccaaaaca ccatctagct
    53281 tttcatttat tttagactct tgttttaaaa aacttgctgt gacatttaaa acagtgtttc
    53341 ttattatatt attttcactc aaaaccttca ctccttaaat caattatttt attgtaatat
    53401 ttacattgtg caaagttgct aatttgatta tgatatctaa ataattattt actaaatttg
    53461 ctacatctta tatcatatca tattatttac atcattttac tttttctttt tatatctatc
    53521 ttatattata ccatttttaa tatctgtact aacttatatt acaatattcc tcaaaatttt
    53581 aaaagtagat tagacaaatt tacaaataaa aaaacatcag tttaaactga tgtttttgac
    53641 tatcgaaata attaagcaag tctataagcg gagttctgta ttagataatc atctttctag
    53701 gcctattgtc accaataggc tcaagcgacc tacctaccgg agagtacgag cagcactctt
    53761 tattcctatc ttggtcttgc tccaggtggg gtttacatag ccaactagtc gcctagctgc
    53821 tggtgagctc ttacctcgcc tttccatcct taccacaata gtggcggttt atttctgttg
    53881 cactatcctt aggatcgctc ccactaggcg ttacctagca ccctgctcta tggagctccg
    53941 actttcctca tgtaagatta catgcgatta tctggcttac ttaatattta ttttacttag
    54001 ttatgttaac acaaattctt ttacatgtca aagtaatatt atactaaaaa tttaaattta
    54061 ttcaaaaata gtgtaatata gatatataaa ctacatttaa ctcgaggtga tctattgaaa
    54121 aaattatata gaatagtaat taacattata ctagtattag taatacttta cagtggattt
    54181 aatatatact caaaacttac caaatacaat catgatacta aaatatcctc agaacttcaa
    54241 aaaaaagaat ataaaaaaga ggatttatca aagattaaca gtgattttaa attttggctt
    54301 tctgttgaga atacaaatat aaattatcca gttgtacaat ctaaagataa ttcttactat
    54361 cttgacaaag atttttataa aaaagattct atttctggta cactgtttat ggattataga
    54421 aataaatcta ttgatgacaa aaatatcata atatatggac ataatatgaa aaataaaact
    54481 atgttcaaca acctaaataa gtttaaagat gctgacttct ttaaaaaaaa taataaaata
    54541 aaaataacct tgaatggaaa agaattttta tatgatgttt tttctgctta tattgtagaa
    54601 tctgattatg attatctaaa aacaaatttt aacaatgaat ctgattatca aaattacata
    54661 aatgatatta cttctaaatc attgtataaa tctcctatta aggtaaatag caatgataaa
    54721 atagttacac tttctacatg tacctatgaa tttgatgatg ccagaatggt gattcatggt
    54781 agattgattt aaaactcaca gacacagttt aaaacaataa ttttaaactg tgtcatcttt
    54841 tatacctata atttgtaaat tagaccacta aaagtattta atacaaaata acaaatacat
    54901 caaacaataa aaaacaataa aaaaagacta tgctaaaaac atagtcttta ctggagctgg
    54961 tgataggaat cgaacctaca acctgctgat tacaagtcag ctgctctacc gttgagccac
    55021 accagcacac ctattttatt gtaaattagc aaaactaatt tttaaaagtt a
//
LOCUS       DAEPID010000019        54053 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.019, whole genome shotgun sequence.
ACCESSION   DAEPID010000019 DAEPID010000000
VERSION     DAEPID010000019.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 54053)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 54053)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..54053
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.019"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            109..948
                     /locus_tag="KR257_001279"
     CDS             109..948
                     /locus_tag="KR257_001279"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420697.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TIGR00159 family protein"
                     /protein_id="HBH0029993.1"
                     /translation="MLDINSFLNGFFNIILRMSIYDLIDISIVAYIFYKIFMFIKDTR
                     AEQVFKGIIFLLLATQLSNTFKLHTVYWISLKALDYGVIAALIIFQPEFRAGLEHIGR
                     AKFNLFGKNVNTSEETLNRNIEEIVEALYSLSRQKIGALIIMERETRISDIINTGTII
                     DAEISRQLLINIFIPNTPLHDGAVVIRDSKVKAAACFLPLTESKDLSKDLGTRHRAGI
                     GVSEVSDCITLIVSEETGGVSIAKAGKLYRDISRERMMNILRSNLKTNTETRSFFKGG
                     IFK"
     gene            945..2126
                     /locus_tag="KR257_001280"
     CDS             945..2126
                     /locus_tag="KR257_001280"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420699.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0029994.1"
                     /translation="MINRLKNNTKIKIISFLSAIALWMYVMAVVDPEETKGFEDIPVS
                     ISNMSDLKDKNLVIYPDEKLTADVYIKGSLSKVQSVKKEDIHVYGTIEDPIQGQKEVY
                     LKANIPQGVTLEFKHDVLVVNLEKNIKEKRDIKVEVSGNSKRNINKIELSKEFVDVSG
                     PRTLVKEVKSVRANLDVGNETDDFSKKLQLIPLNSDGTKVEGVTLSSSFVTAKIELLK
                     EKIVPIRVSLNDNKDNDVLKNYKLSKEQVTIKGKKEDIDKISYIKTKPIDLADLANGE
                     EKEVSLEIPEGITLEDSSITIKLNDTKQLSAEFLYNAGDIELRNIPTNMDNPNVISDV
                     DIKVVVESTEDLSKLNKKDISLYIDLSQGPEEDSKYKIKYETTYQFKKINIEPNIVEV
                     E"
     gene            2430..3332
                     /gene="ptb"
                     /locus_tag="KR257_001281"
     CDS             2430..3332
                     /gene="ptb"
                     /locus_tag="KR257_001281"
                     /EC_number="2.3.1.19"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425473.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphate butyryltransferase"
                     /protein_id="HBH0029995.1"
                     /translation="MRSFEEVIKFAKERGPKTISVACCQDKEVLMAVEMARKEKIANA
                     ILVGDIEKTKEIAKSIDMDIENYELIDIKDLAEASLKSVELVSQGKADMVMKGLVDTS
                     IILKAVLNKEVGLRTGNVLSHVAVFDVEGYDRLFFVTDAAMNLAPDTNTKKQIIENAC
                     TVAHSLDISEPKVAAICAKEKVNPKMKDTVEAKELEEMYERGEIKGCMVGGPFAIDNA
                     VSLEAAKHKGINHPVAGRADILLAPDIEGGNILYKALVFFSKSKNAGVIVGAKAPIIL
                     TSRADSEETKLNSIALGVLMAAKA"
     gene            3354..4433
                     /gene="buk"
                     /locus_tag="KR257_001282"
     CDS             3354..4433
                     /gene="buk"
                     /locus_tag="KR257_001282"
                     /EC_number="2.7.2.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420702.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="butyrate kinase"
                     /protein_id="HBH0029996.1"
                     /translation="MSKIFKILTINPGSTSTKIAVFDNEDLVFEKTLRHSSEEIGKYE
                     KVSDQFEFRKQVIEEALKEGGVKTSELDAVVGRGGLLKPIKGGTYSVSAAMIEDLKVG
                     VLGEHASNLGGIIAKQIGEEVNVPSYIVDPVVVDELEDVARISGMPEISRASVVHALN
                     QKAIARRYAREINKKYEDINLIVAHMGGGVSVGAHKNGKIVDVANALDGEGPFSPERS
                     GGLPVGALVKMCFSGKYTQDEIKKKIKGNGGLVAYLNTNDAREVEERIEAGDEKAKLV
                     YEAMAYQISKEIGASAAVLKGDVKAILLTGGIAYSKMFTEMIADRVKFIADVKVYPGE
                     DEMIALAQGGLRVLTGEEEAQVYDN"
     gene            4423..5100
                     /locus_tag="KR257_001283"
     CDS             4423..5100
                     /locus_tag="KR257_001283"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425471.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding protein"
                     /protein_id="HBH0029997.1"
                     /translation="MITNDKRIRIITGHYGSGKSEFAMNYVVKLRDMVSGKVAIADLD
                     VVNVYFRTREKKELMKSLGIQPIDSSINAPTLDLPAVSAEVMSPMVDHSYNSVIDLGG
                     DNVGARVIGRFSHLLKEGDYDMLFVINANREKTQTSEEVIQYIKEIEKSSKLKVTGLI
                     NNTHLIRFTTIDDVLRGQKVAKEVSEKCNIPIRYVACLENLVEQLPKDLEGEIFPIKL
                     YMREDWM"
     gene            5143..5358
                     /locus_tag="KR257_001284"
     CDS             5143..5358
                     /locus_tag="KR257_001284"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420706.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="4Fe-4S binding protein"
                     /protein_id="HBH0029998.1"
                     /translation="MAKGKVSFNQERCKGCGLCVEACPVKIIQLDSNVINKKGYNPAT
                     VFEMEKCIGCASCATMCPDVVITVERD"
     gene            5387..6466
                     /locus_tag="KR257_001285"
     CDS             5387..6466
                     /locus_tag="KR257_001285"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420707.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="3-methyl-2-oxobutanoate dehydrogenase subunit
                     VorB"
                     /protein_id="HBH0029999.1"
                     /translation="MAKILMKGNEAFGKAAIEAGCKYFFGYPITPQSELPEYLSRELP
                     KIGGAFVQAESEVSAINMVYGGAGAGARVMTSSSSPGVALKQEGITYAVGAEVPCVVL
                     NVMRGGPGLGSIQPSQADYFMSTRGGGNGDYRTPVFAPATVQEAVDMIMEAFDVADYY
                     RSPVMVVADGMIGQMMEPVEFRAPEKKRELPPKDWATVGTKGKRKPNVINSLYLEPEV
                     LEDHCWHLQEKFDAMEKNEVQYEMYKTEDAEFVFAAYGTTSRVVKSAIDILREEGIKA
                     GLIRPKVLWPFPFEAFNQIPNARNILTVEMSMGQMVEDVKMAVEGKLPVYFHGRPGGM
                     TPTPAEIVEKAKKIIAGELVAGGAR"
     gene            6466..7218
                     /locus_tag="KR257_001286"
     CDS             6466..7218
                     /locus_tag="KR257_001286"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420710.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="2-oxoglutarate oxidoreductase"
                     /protein_id="HBH0030000.1"
                     /translation="MAVVFKKTEGLQDTQTHYCPGCTHGIIHRLVGEVLEELGVLGDA
                     VGVVPVGCSVLGYKYFNCDTQEAAHGRAPAAATGIKRVHPENTVFTYQGDGDLASIGT
                     AEIVHAAARGEKITTIFVNNTTYGMTGGQMAPTTLVGQRATTAQSGRNAETQGYPIRV
                     SEMLATLTGAVFVERVAVDTPAHVRQAKKAIKKAFQVQQAGLGFGIVEVLSTCPTNWG
                     LAPNDALQWLRDNMIPYYPLGNFKNVEVEEVK"
     gene            7219..7776
                     /locus_tag="KR257_001287"
     CDS             7219..7776
                     /locus_tag="KR257_001287"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420711.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="2-oxoacid:acceptor oxidoreductase family
                     protein"
                     /protein_id="HBH0030001.1"
                     /translation="MSTARVICAGFGGQGVMSMGQLLTYAGMLEGKEVSWLPSYGPEM
                     RGGTANCAVTVSNEPVGSPLITDDATAAILLNIPAFEKFKDDVIPGGKIIVNSSLIKE
                     KVDRTDVDVYYIPANELAAELGNDKVANMIMLGAYLKVSDTVDIESVLEAFKKVFGPR
                     KEKFVPLNREALQKGMDATCSKATN"
     gene            7946..9292
                     /locus_tag="KR257_001288"
     CDS             7946..9292
                     /locus_tag="KR257_001288"
                     /EC_number="5.4.2.10"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860638.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphoglucosamine mutase"
                     /protein_id="HBH0030002.1"
                     /translation="MRKYFGTDGVRGVANTELTCDLAYKLGRAGGFVLAQGDHRVKVV
                     VGKDTRISGDMLEASLIAGLMSVGCDVITVGIIPTPAVAYLTRKYGADCGVVISASHN
                     PVEYNGIKFFNKNGYKLDDEIELKIEEYIDDIDKIDCLPIGENVGRKLHEHCAQRDYV
                     DYLKSIISTDFKGLKVVLDCANGASYKVAPIVFDELGASVISINSSPDGNNINYKCGS
                     THPEQLQRAVLEHNADLGLAYDGDADRLIAVNEKGQIVDGDHIMILSALNLKKNNKLA
                     QDTLVVTVMSNIGLTIAAKENGINLSTTAVGDRYVLEDMVKNGYNLGGEQSGHMIFLD
                     YNTTGDGVLSSLILANIILQEKKPLSEIASIMSQYPQVLVNATIKNENKNKYMEYPEI
                     KTEIERIESILDGNGRVLIRPSGTEPLVRVMLEGKEEGQIKELATNLANLIQEKLS"
     gene            9559..11391
                     /gene="glmS"
                     /locus_tag="KR257_001289"
     CDS             9559..11391
                     /gene="glmS"
                     /locus_tag="KR257_001289"
                     /EC_number="2.6.1.16"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003401499.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glutamine--fructose-6-phosphate transaminase
                     (isomerizing)"
                     /protein_id="HBH0030003.1"
                     /translation="MCGIVGYLGSRKAAEVIVEGLSKLEYRGYDSAGVAVNSSNEKEL
                     NIRKFKGRLSVLAEDLEKNPIDGNLGIGHTRWATHGEPSDVNSHPHFNQAKTIAVVHN
                     GIIENYMEIKEELISEGVKFESQTDTEVIAHLVDKYYEGNLLDAVYKTISKLRGAYAL
                     GVICKEHGNELVAVRKDSPLVVGVGEGENFIASDIPALLKYTRDVYFLENGEVVHLKD
                     ENVTVYDSNRNLVEKEVFHVTWDVEAASKGGYDYFMSKEIHEQPTGVRETLERRLDDN
                     GNIILDSINISKEDLEKINKVYIVACGTAYNAGLLGKYAIEKFVNIPVITDIASEFRY
                     SDPFVDENSLVILVSQSGETADTLAVLRDSKAKGARILSITNVVGSSIARESDDVFYT
                     WAGPEVAVASTKAYTTQITSLYMIALDFAIKKGTITREFYDSMISKMKEIPSKIQEIL
                     DNEEYIKEVAKTVVSSEHAFYLGRGIDYSLAMEGSLKLKEISYIHAEAFAAGELKHGT
                     IALIEKGTPVIAIATQEKLFEKMVSNMEEVRARGAYVVAIAQSHNKDVEKAADKIIYI
                     PNSDDILSPILAVVPMQLLAYHVSVLRGCDVDKPRNLAKSVTVE"
     gene            11842..13137
                     /locus_tag="KR257_001290"
     CDS             11842..13137
                     /locus_tag="KR257_001290"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860639.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="thiosulfate sulfurtransferase"
                     /protein_id="HBH0030004.1"
                     /translation="MTNDFKKEKKEDYFVNLKAISTEVLQEKVQDNAWVIVDTRLNDA
                     YNGWKLDGVKRGGHIKGAVDFSANWLSVYSDRKDEVLEQALKTKRIDLDKNIVLYDAN
                     GKDALVVADYLSKKGYKYLYKYDIKQWADNENLPMERYKNYQMIVPAFIIKDILDGKI
                     PETFEDSKNIKMIEASWGEESYTKGHIPTSVHVNTDIIEPPPTWMLDNDDNLIKFALD
                     YGLTKDDTVIVSSSTPMASYRLAVILRYIGVKDVRVLNGGTNSWLSAGYELEFTSNPK
                     HSCTNFGADIPVNSQLVVTTSELRQKLKEKNKFILVDNRTWDEHIGKVSGYTYYDKKG
                     RIPGALYGHSGSDSVSLEEYRNIDNTMRNKYEILEMWDKENIDVNRQLIFMCGSGWRA
                     AEVLTYANVIGVENTSLYSDGWMGWSLDNSNLIEVGEHK"
     gene            13587..14324
                     /locus_tag="KR257_001291"
     CDS             13587..14324
                     /locus_tag="KR257_001291"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003432450.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YwmB family TATA-box binding protein"
                     /protein_id="HBH0030005.1"
                     /translation="MKRVKLAISFFILMIIGMTISYADTSINTKYNRLSKALEISEAN
                     FKFYNVKINSVINHNLSNKEFHNIFIEIINNLKLDKKGINWNQKGSGDKIQLCATIKG
                     SDKEISIKGINKNNKESYIVVDILDNKVYKHKEVIYSNVENVLNKYSSQVDVSACIVG
                     EYTKRLQNNKYDDILQKILYNMSAKQIDEVKDVNFLSITAYSKVLNDYELEYLGEKIN
                     LNIGIKYNEDDGRTLIYIATPIIKLDY"
     gene            14345..15598
                     /gene="murA"
                     /locus_tag="KR257_001292"
     CDS             14345..15598
                     /gene="murA"
                     /locus_tag="KR257_001292"
                     /EC_number="2.5.1.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420721.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-N-acetylglucosamine
                     1-carboxyvinyltransferase"
                     /protein_id="HBH0030006.1"
                     /translation="MAKIIVKKSNPLKGSVKIDGAKNAVLPIIAATLLANGKSTLNGV
                     PNLRDVHVISDLLRHVGAEVEYKENTLTVDASNIKTCEAPYELVRKMRASFLVMGPLL
                     ARFNSTKISMPGGCAIGTRPIDLHLKGFKALGAKIEMDHGFVEAATEKLVGNKLYLDF
                     PSVGATENIMMAASLAEGTTIIENAAEEPEIVDLANFLNEMGADVKGAGTNTIKIKGV
                     KELKGAEHNVIPDRIEAATYMVAAAMTKGDITVENVLMEHLKPVVAKLREAGCEITEM
                     DNSVRVVGPKVLKPIDIKTLPHPGFPTDVQAQFMAMLTVANGTGVVIETVFENRFMHV
                     AEFNRMGANIKIDGRSAVVNGVDELHGAAVNATDLRAGAALILCGLIAEGETQIGEIY
                     HIQRGYVDIDKKITALGGQIEIVED"
     gene            15685..16749
                     /gene="spoIID"
                     /locus_tag="KR257_001293"
     CDS             15685..16749
                     /gene="spoIID"
                     /locus_tag="KR257_001293"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009887965.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="stage II sporulation protein D"
                     /protein_id="HBH0030007.1"
                     /translation="MKNPLVVLLGFVTCSVLVPSLITLVSYKNVELTEKAESPVSINK
                     TIKKSDIEDKGNKEEKNTVNYETVNKKAPIINVYNHITGKTEKMDMENYLCGVLAGEM
                     SSEFDIEALKAQSVAARTYVVYKQEHGKSSKHKNAVVCTDYKHCQEYKSYDTLKKLNG
                     EEWIKNKYSKIQEAVRGTKGQIITYNDKAILPLYFSTSSGKTENSEEVFSAKYPYLKS
                     VESPYDKYSPKFASTLKISNTDFVKSLRRAYSTIVIDVNNLSKQVSITKRSDAGTVEK
                     IKLGNKELTGKDIRTVFKLNSANFDIKFGEGYIDFVVKGYGHGVGMSQWGAEGMAEEG
                     YKYYDILSHYYTDTKIKDIY"
     gene            16815..17483
                     /locus_tag="KR257_001294"
     CDS             16815..17483
                     /locus_tag="KR257_001294"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420724.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="M23 family metallopeptidase"
                     /protein_id="HBH0030008.1"
                     /translation="MKKKLLEKDGFYLSLFVCVCLLAVGGVWFTNNNVDKLASNKGIM
                     ENANKDSEEEIHLIEKDKKDAIPTATDSKQNLEKAKSKEENKSSTTKLNYIGDKVIRG
                     YSEKEPSYSKTLDVWETHKGVDISCTKGKEVKSLLNGIVVDVFNDEEYGQSVKIKSDN
                     NIVVVYSNLDKNVSVKKEQKVTEGQSLGTVGSTSQIESEEGIHVHLEAYSGEKSIDPM
                     SLIK"
     gene            17581..17841
                     /gene="spoIIID"
                     /locus_tag="KR257_001295"
     CDS             17581..17841
                     /gene="spoIIID"
                     /locus_tag="KR257_001295"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420727.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sporulation transcriptional regulator SpoIIID"
                     /protein_id="HBH0030009.1"
                     /translation="MRSHIEERAIVVAKYILEKNTTVRQTAKTFGVSKSTIHKDVTER
                     LKEINPSLAKEVKNVLDKNKSERHIRGGLATKLKYEKEHKKM"
     gene            18038..19057
                     /locus_tag="KR257_001296"
     CDS             18038..19057
                     /locus_tag="KR257_001296"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009901591.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="rod shape-determining protein"
                     /protein_id="HBH0030010.1"
                     /translation="MAGADIGIDLGTANVLVYVSGKGIVLEEPSVVAIDNRTDSVLAV
                     GEEAKKMIGRTPGNIVAIRPLRDGVISDYDVTEKMLKSFIDKIVDKKGFGRFFMPRIM
                     VCVPTGVTEVEKRAVEDATRQAGAREVYIIEEPIAAAIGAGVDISQPNGNMIIDIGGG
                     TVDIAVISLGGAVVSESIKVGGDRFDDAIVKYMKKQHNLLIGERTAEKIKFEIGSAFK
                     REEEKYMKITGRNLITGLPSSITINSTEMLEALRECVEQIVVATHAVLEKTPPELAAD
                     IGDVGIIMTGGGSLLYGLDKIIEQRTGITVTIADEPLSCVAKGTGIALGSIDLLETGG
                     SFKRK"
     gene            19073..19501
                     /gene="fabZ"
                     /locus_tag="KR257_001297"
     CDS             19073..19501
                     /gene="fabZ"
                     /locus_tag="KR257_001297"
                     /EC_number="4.2.1.59"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425446.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="3-hydroxyacyl-ACP dehydratase FabZ"
                     /protein_id="HBH0030011.1"
                     /translation="MLNIDEIKKLIPHRYPFLLVDKITELEVGKRAVGIKNVTVNEPF
                     FQGHFPEYPLMPGVLIVEALAQVCGVAMMSVEENKGKLGVFAGIDKVRIKREVRPGDT
                     LTMEVEMTTLRRNIAKADAKAYVGEELVCKGELMFALVEK"
     gene            complement(19612..20121)
                     /gene="yyaC"
                     /locus_tag="KR257_001298"
     CDS             complement(19612..20121)
                     /gene="yyaC"
                     /locus_tag="KR257_001298"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009887970.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="spore protease YyaC"
                     /protein_id="HBH0030012.1"
                     /translation="MYLAKVNYSDDDVIQMLSSVLKTIINENTIVVCIGTDRAIGDTL
                     GPLVGTILKNSNFKYPVYGTLDNPIHALNIYESLDTIKNTHIQGNFLAIDACLGSQSN
                     IGNIQIREGPILPGKGVGKKLPQIGNYSIVGIVDKIDENNKLSFNNIRLSFILDLAET
                     IALALLVST"
     regulatory      20310..20413
                     /regulatory_class="riboswitch"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00162"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="SAM riboswitch class I; Derived by automated
                     computational analysis using gene prediction method:
                     cmsearch."
                     /bound_moiety="S-adenosylmethionine"
                     /db_xref="RFAM:RF00162"
     gene            20549..21742
                     /locus_tag="KR257_001299"
     CDS             20549..21742
                     /locus_tag="KR257_001299"
                     /EC_number="2.5.1.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003432462.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="methionine adenosyltransferase"
                     /protein_id="HBH0030013.1"
                     /translation="MARHLFTSESVTEGHPDKICDQISDSILDALLEKDPQSRVACET
                     TVTTGLVLVAGEISTSAYVDIPKLVRETVREIGYTRAKYGFDCDTCAVITSIDEQSGD
                     IAMGVDEGLESKTGEEIEEEIEKVGAGDQGIMFGFACNETPELMPLPISLAHKLSRRL
                     TEVRKTGLVDYLRPDGKTQVTVEYEGSKAVRVHTVLISAQHCETVSNDKIREDLINHV
                     IKEVIPAELLDEDTKIYINPTGRFVIGGPQGDTGLTGRKIIIDTYGGYSRHGGGAFSG
                     KDPTKVDRSAAYAARYVAKNIVAAGLADKCEIELAYAIGIARPLSIFIDTFGTGKVSE
                     EKLVELVNKHFDLRPGAIIRDLDLRKPLYKKVAAYGHFGRTDIDLPWERTDKVEQLRK
                     DALGE"
     gene            22057..23154
                     /locus_tag="KR257_001300"
     CDS             22057..23154
                     /locus_tag="KR257_001300"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003432466.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0030014.1"
                     /translation="MSGKVNIKTVISFAGAYVATVIGSGFATGQEILQFFTFYGYAGI
                     IGGIISMVLFSWFGAEVIDKGRELKLKEPIKIYQVYCGKYLGTFFEWFGPLFLFGTLV
                     IMIAGAGATLSEYYGLNPYVGRIGMTIVSLITVSLGLTRLSKILGNIGPIIIIFTLLV
                     GAISLFSNIDALSNAGNMVDSLNIKTATSNGYFSGVLYTCYNVIIVITFLTGMGASAV
                     NKKDAVWGGIVGGVALMAAAIMMNLALLSDIGNIYTKEIPALYLADKISPIIGILFSV
                     VLLLGIYTTAVPLLWSVTNRFVEDDHPKFKIITIVVSILACIGGLLPFDKLVGTLYPY
                     TGYMGILILLCMLYRRITKTEGYKENKSEIS"
     gene            23418..25637
                     /locus_tag="KR257_001301"
     CDS             23418..25637
                     /locus_tag="KR257_001301"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425443.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-dependent RecD-like DNA helicase"
                     /protein_id="HBH0030015.1"
                     /translation="MEKLEGMISEIVFKNEDNGYTIAHLVNENDEIVVVGCMPTLAIG
                     ESIEVEGKWVNHKIYGTQFEVNSFMPVTPSSLEGIYVYLSSGMIHGIGEKMAKRIIDK
                     FGVDTLEVIQNSPEKLQEVEGIGSKKVKQIVKSYEEDRELRNIIIQLSPFGITPNYCL
                     KIYKKYKSSAIEVINKNPYQLAEDIRGIGFKVADSIANKIGIDKNSKDRICQGILYTL
                     NKSLSNGHTYLPEHVLIQDSEKLLELNGEIIKECVMMLVYNQKIHVEKVNNENLIYLM
                     PYYLAENGVCSQIVKLSQYEFEDLKIDIDNEINVLEEDKKIKLAEKQILAVKESVNSG
                     VLIITGGPGTGKTTTINAIIDIFENNGKSVTLAAPTGRAAKRMSETSNKEAKTIHRLL
                     EMGFSTDDDLTFFKDEEDPINSDVIIVDEVSMVDIILMYNLLRAIKLGTRVILVGDSD
                     QLPSVGAGNVLKDMINSNIINVVKLNEIFRQAQESMIIVNAHKINNGEPLYLNTKGKD
                     FFFIRKSTNEEILNEIIGLVNERLPKFYKVDKLKDIQVLSSMRKGELGVTNLNIELQK
                     YLNKKEKFKVEESFSKRLFRVGDKVMQVKNNYTKKWETEDQKESGEGIYNGDIGYVYH
                     IDKDKKTIYILFDQTKIVSYLYDELDEIDHSFCTTIHKSQGSEFPVVVLPIAWAPPML
                     LSRNLLYTAVTRAKKLVVLVGDVKYLEYMIKNNRVNQRYSNLGYKLNKFKQEGLLIE"
     gene            25640..26422
                     /locus_tag="KR257_001302"
     CDS             25640..26422
                     /locus_tag="KR257_001302"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434403.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ComF family protein"
                     /protein_id="HBH0030016.1"
                     /translation="MKICNDNFIKNFKNMINKCLDFIYPENISCIICDKSIKKTNTYS
                     ICKSCFKEMNFIQDGCMKCGKPIIRHSIEKEFIEECSYCFNKDFYFDKSISCIEYNDV
                     TKKIVLGLKYNQKTFMAKYIAQIMKEKLYLENIKFDYILFVPLHKKRLNKRGFNQAQK
                     IAFNLSKIVNIPLLDCISRKKYTRMLYKLNKKERKEELKNVFVVKDNVKLINNKNILL
                     IDDIFTTGLTTNEISKLLKLSGANKVFVLTLLTKANDNYIME"
     gene            26754..28667
                     /locus_tag="KR257_001303"
     CDS             26754..28667
                     /locus_tag="KR257_001303"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421838.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcription antiterminator"
                     /protein_id="HBH0030017.1"
                     /translation="MICLNKRQENLLTTLLLKEEFINVNKIANDFECSERTIRNDCKY
                     IDEWLSTFCNAYIKRKPNIGIKFSGDGTDKILVNQKLRGEVKRVNSELHKQVEILNLL
                     LCNNKKVTLNDLSNKLYINKNIVREEISKLSVALNNYNLNVSTKKGSGIYIGGDEKDI
                     RIMLVSFLFKYIDKYRLNIDEIEYFHIVDIIIVKNIMFTIEEDMDIRLTDISFKQLML
                     FLLINIIRIRLGNSLKVSNTKKELKLKMLILDIEDELKSNLSIVLNYEEKLFIESLIL
                     GMNKQINSSNIKKSLYLNEELASYTKKIINLVSEESGINFNNDILLYEQLICHLNVTM
                     HQMKSNVYLENPLLDNIKTKFCFLFTVISSSIEIELKGKQITEDEIGYLTLHFQTSLE
                     RKYSKRESNKKASIVCPFSFGVSMLLKVKIEKRFDNIKIIETLREEDLKRDNFNKTID
                     FIIAFQEYENIQKPIFITTPLFTDEDENKLKEFTNKIKEKDTSYKLMNRLMMSDYLIR
                     ELEHDDIYEAITYLTNLLIEKHYAEKEYLQSIITREKSYPTNVGKGILFPHGDMKYIK
                     QSVLCFARLKTPIRIRNGKDIKIILLLAYKKDDDRKVFRELFKEISNLTEDENMLDIL
                     SKCDIEKVKDILI"
     gene            28808..29116
                     /locus_tag="KR257_001304"
     CDS             28808..29116
                     /locus_tag="KR257_001304"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420747.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS lactose/cellobiose transporter subunit IIA"
                     /protein_id="HBH0030018.1"
                     /translation="MEEIVLKIIIHAGNAKSMLYEALDYAKENDFKKADELIENANEE
                     ILKAHKVQTELIQKEAGGDKSDISILLIHSQDHLMTCMSERNLIKEMIMLRKEIQKLK
                     "
     gene            29140..29466
                     /locus_tag="KR257_001305"
     CDS             29140..29466
                     /locus_tag="KR257_001305"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425440.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIB"
                     /protein_id="HBH0030019.1"
                     /translation="MKRKVYLFCSFGMSTSLLADKMQKVADEHNLPIEVEAFPIAEID
                     KIVEEKNPDCILLGPQVKYMLKELKPKFEAQGKLIDIINEVDYGTMNGEKVLKLAIKL
                     IKSKQA"
     gene            29505..30839
                     /gene="celB"
                     /locus_tag="KR257_001306"
     CDS             29505..30839
                     /gene="celB"
                     /locus_tag="KR257_001306"
                     /EC_number="2.7.1.205"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009901597.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS cellobiose transporter subunit IIC"
                     /protein_id="HBH0030020.1"
                     /translation="MNRLERILMPLAEKIGKNKLLIAIRDGFLISSPLLIIGSLFLLV
                     ANFPIKGWNEFVGQIFGSDWAVKLQQPTVATFEVMTLLAVLGIGYSYAKQIDVDPIAS
                     AAVAIVAFFIITPFVIPYTPEGTESVYMVTGIPLGWMGSKGMFVGMITAITSVKLFAA
                     VVKKGWTLKMPDGVPPTVSKSFAALIPSAIVMVVFFLVKIAFEATPYGSIHEFIFKFL
                     QMPLLKLGNSLGAMAIAYIFLHLFWFFGINGSSVVGAVYNPILKILSAENLAAFQAGS
                     KIPNIITGQFQDMFATFGGAGSTLSLVIAMLLICKSKRIKSMGKLSILPGIFGINEPL
                     IFGLPIMLNPILLIPFAIVPTINIIIAYFCMSAGLVPLTNGVQLPWTTPIIFSGFLTT
                     GWQGAVLQVVLLILGIFMYIPFIKMLDKQYLREENATVEEEDDDISFDDLVL"
     gene            30850..31368
                     /locus_tag="KR257_001307"
     CDS             30850..31368
                     /locus_tag="KR257_001307"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003432490.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycine/betaine/sarcosine/D-proline family
                     reductase selenoprotein B"
                     /protein_id="HBH0030021.1"
                     /translation="MKKIVMILDQIQAGAGGKEKSNIPPAGKSSPLGPGIMMEQFLNE
                     SKVIATLFCGDEFFVNNEEEVTSKMIAMVKKLNPDVVICGPSFNYENFSKMSAILSKN
                     INDKTDIPAFAAMSEENIDVINEYKNDICIVKTPKKGGIGLNDSLNNICKLAKAIANK
                     EDITLMKEEFCY"
     gene            31464..32423
                     /locus_tag="KR257_001308"
     CDS             31464..32423
                     /locus_tag="KR257_001308"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003432491.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase"
                     /protein_id="HBH0030022.1"
                     /translation="MWGMIATWRMALEGITEASEHLEKGMEAGDAVELAVRRVEDYPF
                     YKSVGYGGLPNENCEVELDAAFMDGNTLDIGAVAGIRDYSNPVSIARKLSYEKVNNFL
                     VGIGAEDYAHKNGFERKNMLTDRAKLHYKKRKKETLDKGLSPYAGHDTVGMISLDKTG
                     KMCAATSTSGLFMKKRGRIGDSALSGSGFYVDSSIGGATATGLGEDLMKGCISYEIVR
                     LMKEGKHPQEACDIAVNELDKQLIKRRGKAGDLSLVAMNNKGEWGVATNIADFTFSVV
                     TKEESPTVYISNRVDGKTIHKVISNEWMEAYEARIKAPIEVSE"
     gene            32472..33524
                     /locus_tag="KR257_001309"
     CDS             32472..33524
                     /locus_tag="KR257_001309"
                     /EC_number="3.4.13.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860644.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Sapep family Mn(2+)-dependent dipeptidase"
                     /protein_id="HBH0030023.1"
                     /translation="MNIISNKIDELKEDLLSDIIDIVKIPSVKGESENGFPFGEKVGE
                     ALNKALEISEKLGFKVRNLDNYIGYAEHGDSDDYVCVIGHVDVVHEGDGWKHQPYKGE
                     ETNGRIYGRGVLDNKGPIMSALYGLYAIKELNLKLDKRVRIIFGTNEESGFEDIPYYL
                     EKEKAPIMGFTPDCKYPVVYGEKGMAKIRIKSKINYEEDVYLGFIENMSENVLVTYKE
                     LNIENSDTILDIKVKYDFSYKLKDVLDEIKASFPNSIDIEVISNFNPVYFDKESNLVK
                     KLQLAYERVTSLDGTPVTTNGGTYAKVMPNIVPFGPSFPGQKGIAHNPDEYMDIEDII
                     LNAKIFANAIYELAKE"
     gene            33527..34201
                     /locus_tag="KR257_001310"
     CDS             33527..34201
                     /locus_tag="KR257_001310"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860645.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="copper homeostasis protein CutC"
                     /protein_id="HBH0030024.1"
                     /translation="MLEIIGMSVEDAKIIEDCGADRIELVSALTEGGLTPSFGLIESV
                     VNSVKIPVNVMIRHHAKSFVYSKEDISIMQKDISVVKEIGANGVVFGVLDKNNSIDEK
                     NLNVLLKCCDNLDVTFHRAIDESNTIDSVKILKDYDKITNILTSGGKGSIVDNIQMIK
                     NMMLSSNHIKILLGGGLNFNNIEKIKELTKASNFHFGTAIRINNSPFEDIDRQKLKQL
                     VNIISR"
     gene            34754..35305
                     /gene="raiA"
                     /locus_tag="KR257_001311"
     CDS             34754..35305
                     /gene="raiA"
                     /locus_tag="KR257_001311"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009887979.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribosome-associated translation inhibitor RaiA"
                     /protein_id="HBH0030025.1"
                     /translation="MNIIISGKQIELTDAIKNKIETKLSKLDNYIHPDTDVKVTVSAR
                     KARQKIEVTIATVNGPIIRAEDMQENLYTAIDVVYDKLSKQLKKYKKRLQDKHKDNKS
                     IRFQDAEINLADEQEDYGDENQELVIQRRKKFSVKPMSEEEAVLQMELIGHDFYMFKN
                     IDSDEIAVVYKRNNGGYGIIEHE"
     gene            35437..38112
                     /gene="secA"
                     /locus_tag="KR257_001312"
     CDS             35437..38112
                     /gene="secA"
                     /locus_tag="KR257_001312"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895216.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="preprotein translocase subunit SecA"
                     /protein_id="HBH0030026.1"
                     /translation="MSFMDNLFNMADKKELKKFNKTVDIIDSLEPKFESMADSELKNM
                     TNIFKERLANGESIDDILPEAFAVVREVSKRVLGLRHYRVQMIGGIVLHQGRIAEMKT
                     GEGKTLVATAPVYLNALTGKGVHVVTVNDYLAKRDRDQMAKIYEFLGMSVGVIIHGQN
                     PKVRKEQYDCDITYGTNNEYGFDYLKDNMVIHKEQRVQRGLNYAIVDEVDSILIDEAR
                     TPLIISGPGDKSTHLYSDANTFVLTLKPDDYELEEKDKAVSLTASGIQKAEVYFNVDN
                     ITDISHTELYHHINQALRAHVIMKKDVDYVAKDGEIVIVDEFTGRLMFGRRYSEGLHQ
                     AIEAKEGLKIQRESKTLATVTFQNYFRMYKKLSGMTGTAKTEEEEFKAIYKMDVFQVP
                     TNKLMIREDLPDCVYKSEIGKFNAVAQEIIERHKVNQPILVGTVSIEKSELLSQILKK
                     KGIKHEVLNAKHHDKEAEIIAQAGRLGAVTIATNMAGRGTDIVLGGNPDFLTKREMRR
                     NGFKEEIVNRVDTPIEGIPVKGNEILFEAREEYEKLFEKFKQQTQEEQKQVVEAGGLA
                     IIGTERHESRRIDNQLRGRAGRQGDPGSSRFYIGLDDDLMRLFGSDRISGIVDKIGLE
                     EDMPIEHRILSKSIEGAQKKVEGKNFGIRKHVLQYDDVMNKQREIIYAERKRVLEGED
                     LQEQIQSMTHSIIEEAVTLYTQDKGFDEEGFKEHMYNLFLPKGSIEIPEIEKLNPVEI
                     TEKVYEIAMKIYTSKEEQVGYERMREVERVILLQAVDNHWIDHIDAMDQLRQGIGLRA
                     VGQQDPVIAYKMEGFDMFDEMNKHIKEDTVRYLFNITIETPVERKAVVDVENLSSPSD
                     GTLPTSKTVKKDEKVGRNDLCPCGSGKKYKNCCGR"
     gene            38127..39234
                     /gene="prfB"
                     /locus_tag="KR257_001313"
     CDS             join(38127..38201,38203..39234)
                     /gene="prfB"
                     /locus_tag="KR257_001313"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_153309863.1"
                     /ribosomal_slippage
                     /note="programmed frameshift; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptide chain release factor 2"
                     /protein_id="HBH0030027.1"
                     /translation="MLKLQEYRHSMEQMASNLEELRVSLDIASLMKNIQINEEKMNKQ
                     DFWNDNEVAQRVLQENKSLKETLEEYESLKSLLEDIEVLIEIGLEEDDDSVERDIEKS
                     IESMEEKLSEMKIKTLLNGEYDKNNAILSINAGTGGLDAQDWAQMLLRMYIRWSESKG
                     YKVKLLDIISDPEAGIKTATILVEGTNAYGYLKSEKGVHRLVRISPFDPSGKRHTSFA
                     SIDVTPELDENIEVEINPSDLKIDTYRASGAGGQHVNTTDSAVRITHIPTGVVVQCQN
                     ERSQHLNKDRAMRLLMAKLIELKELEQKEKIEDIQGKYSQITWGSQIRSYVFQPYKLV
                     KDHRTNAEFGNVDSVMNGNIDLFINEYLKMNKIV"
     gene            39378..41519
                     /locus_tag="KR257_001314"
     CDS             39378..41519
                     /locus_tag="KR257_001314"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011010799.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RNA-binding transcriptional accessory protein"
                     /protein_id="HBH0030028.1"
                     /translation="MDINQILKKEFNLRDEQINNTLKLIDEGNTIPFIARYRKEMTGE
                     MSDVTLREFYEKLMYLRNLQSRKDDVVRLIDEQGKLTDEITQNIEKAKTLQEVEDIYA
                     PYKQKKRTRATIAKEKGLEKLALSILENNLDNIEIEAKNYLDEEKEVLSIEDALKGAR
                     DIIAELVSDDAKIRKYIRELALREGMIVSKSATDEKSVYDMYYDYSEAVKSMPPHRVL
                     AINRGEKENFLKVKLEINNDKVLNYIINEYVNDKNFKNKEEIVSSIEDSYKRLIFPSI
                     EREIRNHLTEIAQERAISVFGKNVKSLLLQPPVKDKVVMGFDPAFRTGCKIAVVDKNG
                     KLLDYTTVYPTDPQNDVEGAKKVLKGLIEKYDIDIISIGNGTASRESETFVSEMIKEI
                     DNEVQYVIVSEAGASVYSASELANEEHPDINVSIRGAISIARRLQDPLAELVKIDPKS
                     IGVGQYQHDLNKKRLEEVLDGVVEDSVNSVGVDLNTASYSLLEHVAGISKTIAKNIIA
                     YREENGDFTSRAQLKKVKRLGPQAFTQCAGFMRILEGKNPLDNTGVHPESYDICKKMI
                     EIIGYSLDDVKNKNICEIDEKIKEIGLRELSEKLEVGQVTLKDIITEIKKPGRDPREE
                     GIKPILRTDVLKIEDIQEGMTLKGTIRNVVDFGAFVDIGIKNDGLVHKSEMSNSFVKD
                     PMSIVTVGDIVDVKVIGIDLNKKRVALSMKK"
     gene            41667..42833
                     /locus_tag="KR257_001315"
     CDS             41667..42833
                     /locus_tag="KR257_001315"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860647.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amidohydrolase"
                     /protein_id="HBH0030029.1"
                     /translation="MIFIKNGKINTITNGIIHGDILIDEGKIIEIGEDLIAPLDVEVI
                     DASNKLVFPGFIDAHTHLGLWEDGIGFEGADGNEETDPITPQLNPIDGINPMDRTFKE
                     AFEGGITSVCTTPGSANVMGGQCIAIKTCGKRIDKMVIKNPVASKIAFGENPKSCYGQ
                     DDKSPQTRMAIAALLRENLKKAEEYLEDIDMYESHDDEDCEKPEYDIKMESLIPVLRR
                     EIPFKAHAHRADDMFTAIRIAKEFNLKLTLDHCTEGHLIVDELVEEGFPVIVGPSLSE
                     RSKFELRNLTFNTAGILSNAGLDVCIMTDHPVIPVQYLPICAGIAVKHGMKEEKAIES
                     ITINPAKTLGIEDRVGSIEVGKDADLVIWDNSPLEIQSNVLYTIINGKVVYEKK"
     regulatory      42893..43010
                     /regulatory_class="riboswitch"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00050"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="FMN riboswitch; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /bound_moiety="flavin mononucleotide"
                     /db_xref="RFAM:RF00050"
     gene            43134..43739
                     /locus_tag="KR257_001316"
     CDS             43134..43739
                     /locus_tag="KR257_001316"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425422.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ECF transporter S component"
                     /protein_id="HBH0030030.1"
                     /translation="MQNTAKRGNMISTRTLVVMSILSAISYLLMFIQAPIPGIFPDFL
                     KIDLSDIPAIFGGMSLGPFVGFGIVVVKNVLQAITATTTGGIGEFANILIGGSYVMIL
                     CYSYKRSGDLKGVLIGFVLGTISMTIIGSLVNYFVMLPLYGQLMGLDAIIGLGSAINP
                     QVHDLFTFVIWMIAPFNVLKAVILSLVTLPLYKKMGNVIKK"
     gene            44068..45108
                     /locus_tag="KR257_001317"
     CDS             44068..45108
                     /locus_tag="KR257_001317"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892574.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4116 domain-containing protein"
                     /protein_id="HBH0030031.1"
                     /translation="MNLSKKIKKLFLDDKGYYFNSNWKDIHIGIYNTKLGDSLKYITN
                     EYIENLERVKYDYRELKNIENQTDGMCILAIRQNYKALEYVKNQTEELCLEAIKYNYK
                     ALEYVKEQTEYICLEAIKKDCNALKYVRNKTERLIIKVIRHSSNIDVVSILKALETQT
                     RRICLEAIKKDGRCLAYVREQSEELCIEAIKQNYKALKYVENQTEKMCIESVRQNGMA
                     LQYVNKQTDKICIEAVKQDGRSLQFVNNKTEEICINAIRYLNKKYNIKDVLSYIDKYT
                     EDICIEIVRQNGKMLMYIKNQTEKMCIEAVKENYKSLKYVKEQSERICKEALKQNHKA
                     KEYVKIAIDDCI"
     gene            45247..45699
                     /gene="tsaE"
                     /locus_tag="KR257_001318"
     CDS             45247..45699
                     /gene="tsaE"
                     /locus_tag="KR257_001318"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434423.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA
                     (adenosine(37)-N6)-threonylcarbamoyltransferase complex
                     ATPase subunit type 1 TsaE"
                     /protein_id="HBH0030032.1"
                     /translation="MAKIYLENENKTREIGYKLGKLLKEGSVICLVGDLGAGKTTMTQ
                     SLADSLGIEDYITSPTFTIINEYEGKIPLYHFDVYRIGSSDEMYDIGYDEYVNSNGIC
                     IIEWANLIEDILPKEYLNIELRYKDDGREMILTPKGEFYKEIVEELIK"
     gene            45699..46415
                     /gene="tsaB"
                     /locus_tag="KR257_001319"
     CDS             45699..46415
                     /gene="tsaB"
                     /locus_tag="KR257_001319"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860649.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA
                     (adenosine(37)-N6)-threonylcarbamoyltransferase complex
                     dimerization subunit type 1 TsaB"
                     /protein_id="HBH0030033.1"
                     /translation="MKILGMDTSSMAASVAVVEDDNLICEFTVNNKKTHSQKLMPMIE
                     NMLSMSDLSIKDMDLLAVCIGPGSFTGLRIGMATVKAMAHVNNIPIIAVNSLESLANN
                     INFCDRKICCILDAQKNQVYSAKYKFENGEMIELDGVDVVEFDALVDEIVSTNEEFII
                     VGEAVYKYKDKLENIKNIKIPSPANNVSNAGSLCSLALNKYNKNIDVHTCYTINPMYI
                     RKSQAEVQYDEKMKRLNNGR"
     gene            46405..46881
                     /gene="rimI"
                     /locus_tag="KR257_001320"
     CDS             46405..46881
                     /gene="rimI"
                     /locus_tag="KR257_001320"
                     /EC_number="2.3.1.266"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009887996.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribosomal protein S18-alanine
                     N-acetyltransferase"
                     /protein_id="HBH0030034.1"
                     /translation="MEDNTKLIVDDIKIEEMTTEDIDEVFEVEKNCFEDYWSKESFRK
                     ELSNEVARYIVAKLNGKIVGYVGIWLILDEGHINNVAVHSDYRGKKIGDKLIKGIVDL
                     CKDNNIASMTLEVRASNKIAQNLYRKYGFKMGGIRKEYYSDNKEDAIIMWNQLKEV"
     gene            46887..47903
                     /gene="tsaD"
                     /locus_tag="KR257_001321"
     CDS             46887..47903
                     /gene="tsaD"
                     /locus_tag="KR257_001321"
                     /EC_number="2.3.1.234"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860650.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA
                     (adenosine(37)-N6)-threonylcarbamoyltransferase complex
                     transferase subunit TsaD"
                     /protein_id="HBH0030035.1"
                     /translation="MSDIITLAIESSCDETAASVLKNGREVLSNIISTQIETHKKFGG
                     VVPEVASRKHVENIDIVVQEALDKANIGFNDIDHIAVTYGPGLVGALLVGLSYAKALA
                     YTLNIPLVGVNHIEGHLSANYIEHKDLKPPFITLIVSGGHTHLVEVKDYGKYEILGKT
                     RDDASGEAFDKISRAMNLGYPGGPIIDNLAKKGNKHAIEFPRAYLEEDSYDFSFSGLK
                     SSVLNYLNGKRMKNEEIVVEDVAASFQEAVVEVLSTKALKAVKEKGYNIITLSGGVAS
                     NSGLRAKITELAKDSGITVKYPPLILCTDNAAMIGCAGYYNFINGKTHDMSLNAVPNL
                     KINQ"
     gene            48200..50908
                     /gene="hpdB"
                     /locus_tag="KR257_001322"
     CDS             48200..50908
                     /gene="hpdB"
                     /locus_tag="KR257_001322"
                     /EC_number="4.1.1.83"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729211.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="4-hydroxyphenylacetate decarboxylase large
                     subunit"
                     /protein_id="HBH0030036.1"
                     /translation="MSQSKEDKIRSILEAKNIKSNFQNKENLSEFNEKKASKRAEDLL
                     DVYYNTLSTADMEFPYWYNREYRKSDGDIPVVRRAKALKSAFSHMTPNIIPGEKIVMQ
                     KTRHYRGSFPMPWVSESFFVAQGEQMREEAKKLASNTADELTKFGSGGGNVTESFGNV
                     VSIAGKFGMRKEEVPVLVKMAKEWVGKSVEDLGFHYEKMMPDYDLKENLMSTLICMFD
                     SGYTLPQGREVINYFYPLNYGLDGIIEMAKECKKAVAGNASGDGLIGMDRLYFYEAVI
                     QVIEGLQTWILNYAKHAKYLESIETDLEAKKEYSDLVEILEHIAHKQPRTFREALQLT
                     YTIHIASVNEDAISGMSIGRFGQILYPWYEQDIEKGLITKEEVIELLELYRIKITCID
                     CFASAGVNGGVLSGNTFNTLSIGGLKEDGSTGANELEELLLEASMRCRTPQPSLTMLY
                     DEKLPEDFLMKAAECTKLGSGYPAWVNNSNGTTFMMKQFADEGMTVEEARAFALGGCL
                     ETSPGCWKQLTLNGKTYSIAGGAGQSAGSGVHFIANPKILELVLMNGKDHRMNIQVFE
                     PHNKPLDTYEEVIEVFKDYYKQAINVLERANNIELDIWRKFDTSIINSLLKPDCLDKG
                     QHIGNMGYRYNATLNVETCGTVTMVNSFAALKKLVYDDKAFTIEEMKDAILNNFGFKD
                     ALEVGNYSMADQVKVDKTGKYDAIYKACLDAPKYGNNDLYADNILKNYEVWLSKVCEE
                     AQSLYAKKMYPCQISVSTHGPQGAATLATADGRLSGTTYSDGSVSAYAGTDKNGVYAL
                     FESATIWDQAVVQNSQMNLKLHPTTIKGQQGTKKLLDLTRSYLRKGGFHIQYNVVDSE
                     TLKDAQKNPDNYRQLMVRVAGFTQYWCELGKPIQDEVIARTEYEGV"
     gene            50912..51169
                     /gene="hpdC"
                     /locus_tag="KR257_001323"
     CDS             50912..51169
                     /gene="hpdC"
                     /locus_tag="KR257_001323"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420806.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="4-hydroxyphenylacetate decarboxylase small
                     subunit"
                     /protein_id="HBH0030037.1"
                     /translation="MRKHSDCMNFCAVDATKGICRLSKQMINLDDAACPEIKVMPKCK
                     NCKNFVEANDEGIGKCVGLEKEDWVYSTLNAITCEGHVFNE"
     gene            51162..52112
                     /gene="hpdA"
                     /locus_tag="KR257_001324"
     CDS             51162..52112
                     /gene="hpdA"
                     /locus_tag="KR257_001324"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895227.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="4-hydroxyphenylacetate decarboxylase activase"
                     /protein_id="HBH0030038.1"
                     /translation="MSSQKQLEGMIFDVQSFSVHDGPGCRTTVFLNGCPLSCKWCANP
                     ESWTVRPHMMFSELSCQYENGCTVCHGKCKNGALSFNLDNKPVIDWNICKDCESFECV
                     NSCYYNAFKLCAKPYTVDELVQVIKRDSNNWRSNGGVTFSGGEPLLQHEFLHEVLLKC
                     HEVNIHTAIETSACVSNEVFNKIFNDIDFAFIDIKHMDREKHKEQTGVYNDLILENIS
                     NLANSDWNGRLVLRVPVISGFNDSDENISDIISFMHKNNLVEINLLPFHRLGESKWIQ
                     LGKEYEYSDKGDVDEGHLGELQDIFLDNGIACYVGHETAF"
     gene            52427..53389
                     /locus_tag="KR257_001325"
                     /pseudo
     CDS             52427..53389
                     /locus_tag="KR257_001325"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018112760.1"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="CPBP family intramembrane metalloprotease"
     gene            complement(53488..>54053)
                     /locus_tag="KR257_001326"
     CDS             complement(53488..>54053)
                     /locus_tag="KR257_001326"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895229.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=3
                     /transl_table=11
                     /product="CPBP family intramembrane metalloprotease"
                     /protein_id="HBH0030039.1"
                     /translation="PIKNIKLGSLLIIYFMISVIVPTSFILILQGSQPNYSGIIKFIF
                     TPITSLTTIYIFFSEEYAWRGFLQNIFFNKFGKKLGVIILGICWSLWHLPLIFTLYTP
                     ETPILGLILRSIHIVGISIFLGYLYIKTKNIWFCAIIHILNNSAFLITNSKESTITYH
                     DILIVSMVVLIFYVPFLFTKEYKNNLE"
BASE COUNT        21775 a         5770 c        10268 g        16240 t
ORIGIN      
        1 aactagaatt atttacataa aagttaaata gtttgtatag agttagattt atatagtata
       61 atacttagtg taaataatta agaagttatc aaacaggagg ataaaactgt gttagatata
      121 aattcttttt taaatggatt ttttaatata atattaagaa tgagtatata tgatttaatt
      181 gacatatcta tagtagcgta tattttttac aaaatattta tgtttataaa agatacaaga
      241 gcagaacaag tgtttaaagg tataatattt cttttattag caactcaact tagtaacacc
      301 tttaaattgc ataccgttta ttggatatct cttaaagctt tagattatgg agttatagct
      361 gctcttataa tttttcaacc agaatttaga gcaggacttg aacatatagg aagagcaaag
      421 tttaatttat ttggaaagaa tgtaaatact tctgaagaaa ctctcaatag aaatatagaa
      481 gaaattgtag aagctttata ttcactttct agacaaaaaa taggagctct tatcataatg
      541 gagagagaaa ctagaataag tgatataata aatacaggaa ctattattga tgctgaaatt
      601 tctaggcaac tattaataaa tatatttata ccaaatacac cattacacga tggagctgtt
      661 gtaattagag attctaaggt aaaagcagct gcatgttttt tgccattgac agaaagtaag
      721 gatttaagta aagatttggg cactagacat agagcaggaa taggggtaag tgaggtgtct
      781 gactgtataa ctttgattgt atcagaggaa acaggtggcg tatcaattgc taaagcaggt
      841 aagttatata gagatatttc tagagaaaga atgatgaata tattacgtag taatttaaaa
      901 acaaatacag aaacaagaag ttttttcaaa ggtggtatat ttaaatgata aatagactaa
      961 aaaataatac caaaataaaa ataatatcat ttttaagtgc aattgcatta tggatgtatg
     1021 ttatggctgt agttgaccct gaagaaacta aagggtttga agatatacct gtatctataa
     1081 gtaatatgag tgatttaaag gataaaaatc ttgttatata tccagacgaa aaattaacag
     1141 cagatgtata tataaaaggt agtttatcaa aggtacaaag tgttaaaaaa gaagatatac
     1201 atgtatatgg aaccattgaa gacccaatac aaggacagaa ggaagtatat ttaaaagcaa
     1261 atattcctca aggtgttact ctagaattta agcatgatgt tttagtagta aatcttgaaa
     1321 aaaacataaa agaaaaaaga gatataaagg tagaagtaag tggaaattca aaaagaaata
     1381 taaataaaat tgaacttagt aaggaatttg tcgatgtatc aggtccaaga actctagtta
     1441 aagaagtcaa aagtgtaaga gctaatctag atgttggtaa tgagacagat gatttttcta
     1501 aaaaattgca attaatacca ttaaatagtg atggaactaa ggttgaagga gtaacattaa
     1561 gttcatcctt tgtgactgca aagatagagc tattaaagga aaaaattgtc ccaataagag
     1621 taagtctaaa tgataataaa gataatgatg tactgaaaaa ctataaatta agtaaggaac
     1681 aagttacaat aaaaggaaag aaagaagata tagacaaaat aagttatatt aagacaaaac
     1741 ctattgactt agctgatttg gctaatggtg aagaaaaaga agttagctta gaaattccag
     1801 agggtataac tcttgaggat agctctataa caattaaatt aaatgataca aaacaattga
     1861 gtgcagaatt tttatataat gcgggagata ttgaattaag aaatatccca acaaatatgg
     1921 ataatccaaa tgtaatttct gatgtagata taaaagttgt tgtagagtca acggaggatt
     1981 tgagtaagtt aaataaaaaa gatatttcat tatatattga tttatcacaa ggtcctgagg
     2041 aagatagtaa atataaaata aaatatgaaa caacatatca atttaaaaaa ataaatatag
     2101 aacctaatat tgttgaagtg gaatgaacaa atatttcgaa tatttagttg ttacaagatg
     2161 cgacaaaaaa acctataaaa ttaagtttgt taattttatg tttttgttgc atcttgttta
     2221 ttttagttat attataaaat aaggacaatg agatatttgt taaatctaaa aagcgctaga
     2281 tatatgaaaa aagactgata aatagattta aataaatatt ttgaattaaa tatttcaatt
     2341 atctctagga aaacgttgct gaacgagtta taatttaatt gagatataaa aagttctatt
     2401 tcaaaaaatt caagatgagg tggaaatgca tgagaagttt tgaagaagta attaagtttg
     2461 caaaagaaag aggacctaaa actatatcag tagcatgttg ccaagataaa gaagttttaa
     2521 tggcagttga aatggctaga aaagaaaaaa tagcaaatgc cattttagta ggagatatag
     2581 aaaagactaa agaaattgca aaaagcatag acatggatat cgaaaattat gaactgatag
     2641 atataaaaga tttagcagaa gcatctctaa aatctgttga attagtttca caaggaaaag
     2701 ccgacatggt aatgaaaggc ttagtagaca catcaataat actaaaagca gttttaaata
     2761 aagaagtagg tcttagaact ggaaatgtat taagtcacgt agcagtattt gatgtagagg
     2821 gatatgatag attatttttc gtaactgacg cagctatgaa cttagctcct gatacaaata
     2881 ctaaaaagca aatcatagaa aatgcttgca cagtagcaca ttcattagat ataagtgaac
     2941 caaaagttgc tgcaatatgc gcaaaagaaa aagtaaatcc aaaaatgaaa gatacagttg
     3001 aagctaaaga actagaagaa atgtatgaaa gaggagaaat caaaggttgt atggttggtg
     3061 gaccttttgc aattgataat gcagtatctt tagaagcagc taaacataaa ggtataaatc
     3121 atcctgtagc aggaagagct gatatattat tagccccaga tattgaaggt ggtaacatat
     3181 tatataaagc tttggtattc ttctcaaaat caaaaaatgc aggagttata gttggggcta
     3241 aagcaccaat aatattaact tctagagcag acagtgaaga aactaaacta aactcaatag
     3301 ctttaggcgt tttaatggca gcaaaggcat aattttaagg gggaaatagg caaatgagca
     3361 aaatatttaa aatcttaaca ataaatcctg gttcgacatc aactaaaata gctgtatttg
     3421 ataatgagga tttagtattt gaaaaaactt taagacattc ttcagaagaa ataggaaaat
     3481 atgagaaggt gtctgaccaa tttgaatttc gtaaacaagt aatagaagaa gctctaaaag
     3541 aaggtggagt aaaaacatct gaattagatg ctgtagtagg tagaggagga cttcttaaac
     3601 ctataaaagg tggtacttat tcagtaagtg ctgctatgat tgaagattta aaagtgggag
     3661 ttttaggaga acacgcttca aacctaggtg gaataatagc aaaacaaata ggtgaagaag
     3721 taaatgttcc ttcatacata gtagaccctg ttgttgtaga tgaattagaa gatgttgcta
     3781 gaatttctgg tatgcctgaa ataagtagag caagtgtagt acatgcttta aatcaaaagg
     3841 caatagcaag aagatatgct agagaaataa acaagaaata tgaagatata aatcttatag
     3901 ttgcacacat gggtggagga gtttctgttg gagctcataa aaatggtaaa atagtagatg
     3961 ttgcaaacgc attagatgga gaaggacctt tctctccaga aagaagtggt ggactaccag
     4021 taggtgcatt agtaaaaatg tgctttagtg gaaaatatac tcaagatgaa attaaaaaga
     4081 aaataaaagg taatggcgga ttagttgcat acttaaacac taatgatgct agagaagttg
     4141 aagaaagaat tgaagctggt gatgaaaaag ctaaattagt atatgaagct atggcatatc
     4201 aaatctctaa agaaatagga gctagtgctg cagttcttaa gggagatgta aaagcaatat
     4261 tattaactgg tggaatcgca tattcaaaaa tgtttacaga aatgattgca gatagagtta
     4321 aatttatagc agatgtaaaa gtttatccag gtgaagatga aatgattgca ttagctcaag
     4381 gtggacttag agttttaact ggtgaagaag aggctcaagt ttatgataac taatgataaa
     4441 agaataagaa tcataactgg tcactatgga agtggtaaaa gtgaatttgc gatgaactat
     4501 gttgttaagt taagagatat ggtttctggc aaagttgcta tagccgattt agatgtggta
     4561 aatgtatact ttagaactag agaaaagaaa gagttaatga aatccttagg tatacaacca
     4621 atagatagct caattaatgc tccaacatta gatttaccag cagtatcagc agaggtaatg
     4681 tctcctatgg tagaccattc atacaattct gttatagatt taggtggaga taatgtaggt
     4741 gctagggtta taggaagatt tagtcatttg ttaaaagaag gcgattatga tatgcttttt
     4801 gtaataaatg caaataggga gaaaactcaa acttctgaag aagttatcca atatataaaa
     4861 gaaatagaaa aatcttctaa attaaaggta acaggtctaa ttaataatac tcatcttatt
     4921 aggtttacta ctattgatga tgttttaaga ggtcagaaag ttgcaaaaga agtttctgaa
     4981 aaatgtaata taccgataag atatgttgca tgtttagaaa atcttgttga acagttacca
     5041 aaagatttag aaggagaaat ttttcctata aaattatata tgagagaaga ctggatgtag
     5101 tttgagctca aatatataga aagtttaagg aggcttaggt aaatggctaa aggaaaagta
     5161 tcttttaatc aagaacgttg taaaggttgt ggattgtgtg ttgaagcatg tccagtaaaa
     5221 atcatacaat tagactcaaa tgtaataaac aaaaaagggt ataacccagc aactgttttt
     5281 gaaatggaaa aatgcatagg atgtgcaagt tgtgcaacta tgtgtccaga tgtagttata
     5341 acagtagaaa gagattaatt taattaatat ttaaggggga attttaatgg ctaagatact
     5401 tatgaaaggt aacgaagcat ttggaaaagc agctatagaa gctggttgca aatatttctt
     5461 cggttaccca ataactccac aaagtgaatt accagaatat ttatcaagag agttacctaa
     5521 aataggtgga gcgttcgttc aagctgaatc agaagtttct gcgataaaca tggtttatgg
     5581 tggagcaggt gcaggagcaa gagttatgac ttcttcatct tcaccaggag ttgctttaaa
     5641 gcaagaaggt ataacatatg cagtaggagc agaagttcct tgtgttgtac ttaatgtaat
     5701 gagaggtggt ccaggacttg gaagtataca accttcacaa gctgactact ttatgtctac
     5761 aagaggtgga ggaaatggag actacagaac tccagtattc gcaccagcta cagttcaaga
     5821 agctgttgat atgataatgg aagcttttga cgttgcagat tattacagat caccagttat
     5881 ggtagttgca gatggtatga taggtcaaat gatggagcca gttgaattta gagctcctga
     5941 gaagaaaaga gaattgcctc ctaaagattg ggcaactgtt ggaactaaag gaaaaagaaa
     6001 acctaatgta ataaactctc tatacttaga gccagaagta ctagaagacc attgttggca
     6061 tttacaagaa aaatttgatg caatggaaaa gaatgaagta caatacgaaa tgtacaaaac
     6121 agaagatgct gaatttgtat ttgcagctta tggaactact tcaagagtag taaaaagcgc
     6181 aattgatata ttaagagaag aaggaataaa agcaggtctt ataagaccta aagtattatg
     6241 gccattccca ttcgaagcat tcaaccaaat tcctaatgct agaaacatat tgactgttga
     6301 aatgagtatg ggacaaatgg tggaagatgt taaaatggca gtagaaggta aattaccagt
     6361 ttacttccat ggaagaccag gaggaatgac tccaacacca gcagaaatag ttgaaaaagc
     6421 taaaaaaatt attgccggag aattggttgc aggaggtgct agataatggc tgttgtattt
     6481 aagaaaactg aaggattaca agatactcaa actcactact gtccaggatg tacacatggt
     6541 ataatccata gattagttgg tgaagtatta gaagaactag gagtattagg tgatgctgta
     6601 ggtgttgttc cagttggatg ttcagtttta ggatataaat attttaactg tgacactcaa
     6661 gaagctgctc atggtagagc gccagctgct gctacaggaa taaaaagagt tcatcctgaa
     6721 aatacagtat tcacttatca aggtgatgga gacttagctt caattggtac tgctgaaata
     6781 gttcatgcag ctgctagagg agaaaaaata actactatat ttgtaaacaa tacaacttat
     6841 ggtatgactg gtggacaaat ggctccaact acattagttg gacaaagagc tactactgct
     6901 caatcaggaa gaaatgctga aactcaaggt tatccaataa gagtaagtga aatgttagct
     6961 acattaacag gagctgtatt tgtagaaaga gtagcagttg atactccagc tcatgttaga
     7021 caagctaaaa aagctataaa gaaagcattc caagttcaac aagcaggatt aggatttgga
     7081 atagtagaag tattatctac ttgtcctaca aactggggac tagctccaaa cgatgcttta
     7141 caatggttaa gagacaacat gataccatac tatccattag gaaatttcaa aaatgttgaa
     7201 gttgaggagg tgaagtaaat gtctacagct agagtaatat gtgcaggctt cggaggccaa
     7261 ggtgttatgt ctatgggaca attacttact tatgcaggaa tgctagaagg aaaagaagtt
     7321 tcttggttac catcttatgg accagaaatg cgtggaggta cagcaaactg tgcagtaact
     7381 gtatctaatg agccagttgg ttctccactt ataacagatg atgcaactgc agctatatta
     7441 ttaaatatac cagcatttga aaaattcaaa gatgatgtta ttcctggtgg aaaaataata
     7501 gtaaatagtt ctttaataaa agaaaaagtt gatagaacag atgtagatgt ttattatata
     7561 ccagcaaatg aattagcagc tgaattagga aatgataaag ttgctaacat gataatgtta
     7621 ggtgcttact taaaagtatc tgatactgta gatatagaat ctgtactaga agcattcaaa
     7681 aaagttttcg gacctagaaa agaaaaattc gttccattaa acagagaagc tttacaaaaa
     7741 ggtatggatg ctacatgttc taaagcaact aactaataaa gaaaaagatg tcaaaaaaaa
     7801 gacaatagaa ttatttctat tgtctttttt gctgataagt attaaaatat ttttatgact
     7861 gaaattaagc ctataatgat attttatgaa ctataaaaat ataatacaaa ttacaagctt
     7921 ttcaattatg aaaggagaat ctttagtgag aaagtatttt ggaacagatg gagttagagg
     7981 agtagcaaat acagaactaa catgtgattt agcatataaa cttggtagag ctggtggatt
     8041 tgtcttagct caaggagacc acagagtaaa agtagtagta ggtaaggata ctagaatatc
     8101 aggtgatatg ttggaagcat ctttaatagc aggacttatg tctgttggat gtgatgttat
     8161 tactgttgga ataataccaa cacctgcagt ggcatattta actagaaaat atggtgctga
     8221 ttgtggtgtg gttatatctg catctcacaa tcctgttgaa tataatggaa tcaaattctt
     8281 taataagaat ggatataaat tagatgatga aattgaattg aaaatagaag aatatataga
     8341 cgatatagac aaaattgatt gtcttccaat tggtgaaaat gtaggaagaa aattacatga
     8401 acattgtgca caaagagact atgtagacta cctaaaatca ataataagca ctgactttaa
     8461 gggattaaaa gtagttttgg actgtgctaa tggtgcgtca tataaagtgg caccaatagt
     8521 gtttgatgaa ctaggagcaa gtgtaatttc aataaatagt tcaccagatg gaaataatat
     8581 aaactataaa tgtggctcta cacatccaga acaacttcaa agggctgttt tggaacataa
     8641 tgctgactta ggtcttgcat atgatggaga tgctgataga ttaattgcag taaatgaaaa
     8701 gggtcaaatt gttgatggag accatataat gatattgagt gccttaaatt taaagaaaaa
     8761 taataaattg gcacaagata ctttggtagt tacagttatg agtaatatag ggttgacaat
     8821 agctgctaag gaaaatggaa taaatttatc tactacagca gttggagaca gatatgtttt
     8881 agaagatatg gttaaaaatg gatataatct tggtggagag caatctggac atatgatatt
     8941 tttagattac aacactactg gagatggagt gcttagttct ctaatacttg caaatataat
     9001 cttgcaagaa aagaaacctt tatcagaaat tgcatcaata atgagccaat acccacaagt
     9061 attagtaaat gcaacaataa aaaatgaaaa taagaacaaa tatatggaat atccagaaat
     9121 aaaaactgag atagaaagaa tagaatctat tttagacgga aatggtagag ttttgataag
     9181 accatcagga actgagccat tagttagagt tatgttagag ggtaaagagg aaggtcaaat
     9241 aaaagaatta gcaacaaact tagctaatct tatacaagaa aaattatcgt aatttaaagg
     9301 gtattctcag atataaatac tgaggacacc tttctaagcg ccagaactta gttatagaca
     9361 taattattga gtaatatagg aactaagttg acgaggtcag agttaatcga attgtcggcg
     9421 gatgctctgc ggtgtgttta ccatcgaaag acttctttaa ataataggag caatcctatg
     9481 gacaaaggga agccaaagta aacttatatg acctaactct taaaatatat aaataatatt
     9541 tttaggagga cacaaataat gtgtggaata gttggatatt taggaagtag aaaggcagca
     9601 gaagttatag tagaagggct ttctaagcta gagtacagag gttatgactc agcaggagta
     9661 gcagttaata gttctaatga aaaagaactt aatattagaa agtttaaagg tagactttct
     9721 gtacttgcag aagacttaga aaagaatcct attgatggaa atttaggtat agggcatacg
     9781 agatgggcaa ctcatggaga accatctgat gtaaactcac atcctcattt taatcaagcc
     9841 aaaacaatag cagttgttca taatgggata atagaaaact atatggaaat aaaagaagaa
     9901 ttaatttctg aaggtgttaa gtttgaatct caaacagata cagaggtaat agcacattta
     9961 gtagataaat actatgaggg taatttatta gatgctgtat acaaaactat atcaaaatta
    10021 agaggagctt atgcattagg tgttatatgt aaagaacatg gaaatgaatt agttgcagta
    10081 agaaaagata gtcctcttgt agttggtgtt ggtgaaggtg aaaactttat agcatcagat
    10141 atacctgcat tattaaaata tactagagat gtttatttct tagaaaatgg agaagtagtt
    10201 catctaaaag acgaaaatgt aacagtttat gactctaata gaaatcttgt tgaaaaagaa
    10261 gtatttcatg taacttggga tgtagaagct gcgtctaaag gtggatatga ctactttatg
    10321 tcaaaagaaa ttcatgagca accaacagga gtaagagaaa ctttagaaag aagacttgat
    10381 gataatggaa atataattct agacagtata aatatttcta aagaagactt agaaaaaata
    10441 aataaagttt atatagtggc ttgtggaaca gcatataatg ctggattact tggtaagtat
    10501 gccatagaaa aatttgtaaa tataccagta ataactgata tagcatcaga atttagatat
    10561 agcgacccat ttgtagatga aaattcatta gtaatattag ttagtcaatc tggtgagaca
    10621 gcagatactc tagcagtatt aagagattca aaggctaaag gagcaagaat actttcaata
    10681 actaacgttg taggttcatc tatagcaaga gaatcagatg atgtattcta tacttgggca
    10741 ggacctgaag tagcagttgc atcaactaag gcatatacta ctcaaataac ttctttatac
    10801 atgatagctt tagactttgc tatcaaaaaa ggaacaataa ctagagaatt ttatgatagt
    10861 atgatttcta agatgaaaga aataccatca aaaatacaag aaatactaga caatgaagaa
    10921 tatataaaag aagttgctaa aacagttgtt agttctgaac atgcattcta tttaggaaga
    10981 ggtatagact atagcttagc aatggaaggt tcattgaaat taaaagagat ttcatatata
    11041 catgcagaag cttttgcagc aggagagcta aagcatggaa caatagcttt aatagaaaaa
    11101 ggaactcctg taattgccat agctactcaa gaaaagttat ttgaaaaaat ggtttctaat
    11161 atggaagaag taagagcaag aggagcttat gtagtagcaa tagctcaaag ccataataag
    11221 gatgttgaga aagctgctga taaaataatc tatataccaa attcagatga tattttatca
    11281 ccaatattag cagttgtacc aatgcaatta cttgcttatc atgtctctgt actaagagga
    11341 tgcgatgtag ataagccaag aaatctagct aaatcagtaa cagttgaata aaaacagatt
    11401 aaaaattaaa tagataatat ttattgaaaa gaactcatcc tgttatttgt attttatagg
    11461 atgagttttt taaataaata ttaaatttgt tttgtttttg ctataataaa ttttataaaa
    11521 agattgatat taaatcatct gtaaaatgat aaatatatag accataccag gtatagggaa
    11581 cgataaatat agttcatata aaatatagtg agtacttaat aaacatatag tcaatatcag
    11641 ataaaaaaaa taatagctta tgagaaaaat taaaatacaa ggtattagta accttgtgat
    11701 aagataaagt gagtagttta aaataagaat ataaggaact atttataaaa gaatataatg
    11761 aagctaataa agtataagaa aattacttta ttttagtaaa ataatttcaa ataaaaattt
    11821 tttaaattgg gagtataaat tatgacaaat gattttaaaa aagaaaagaa agaagattat
    11881 tttgttaatc ttaaggcaat atctactgaa gttttacaag aaaaagtgca agataacgct
    11941 tgggttatag ttgatactcg cttaaatgat gcttataatg gctggaagtt agatggagta
    12001 aaaagaggtg gacatataaa aggagcagta gatttttctg ctaattggtt aagtgtatac
    12061 tcagatagaa aagatgaagt gctagaacaa gcattgaaaa ctaaaagaat tgatttagat
    12121 aaaaatatag tattatatga tgcaaatgga aaagatgctt tggttgtagc agattattta
    12181 tctaaaaaag gatataaata tctatataaa tatgatatta aacaatgggc agacaacgaa
    12241 aatcttccaa tggaaagata taaaaattat caaatgatag ttcctgcttt tataataaaa
    12301 gatatattag atggaaaaat tcctgagaca tttgaagatt caaagaatat aaaaatgatt
    12361 gaagcgagtt ggggagaaga atcgtataca aaagggcata tacctacaag tgttcatgta
    12421 aataccgata ttatagaacc tcctccaaca tggatgcttg ataatgatga taacttaatt
    12481 aagtttgctt tagactatgg attaacaaag gatgatactg taatagtttc aagtagtaca
    12541 cctatggcat cttatagact agctgttata ttgagatata taggagtaaa agatgtaaga
    12601 gttttgaatg gtggaacaaa ctcatggtta tcagcaggat atgaattaga atttactagt
    12661 aatccaaaac attcatgtac taattttgga gcagatatac cagttaactc acaattagtt
    12721 gttactacct ctgaattaag acaaaaacta aaagaaaaaa ataagtttat actagtagat
    12781 aaccgtactt gggatgaaca tataggaaaa gtatctggat atacatatta tgataaaaaa
    12841 gggcgtatac caggagcttt atatggacat tcaggtagtg atagtgtttc actagaagaa
    12901 tatcgtaata ttgataatac aatgagaaat aaatatgaga ttttagaaat gtgggacaag
    12961 gaaaatatag atgtgaatag acagcttata tttatgtgtg gaagtggatg gcgtgctgct
    13021 gaagtattaa catacgcaaa tgtcatagga gtggaaaata cctcccttta tagtgatgga
    13081 tggatgggct ggagtcttga taattcaaat ttaattgaag tgggagaaca caaataaagt
    13141 ttttgaaagt acgatagagt tgtttaaaac aaaggtgttt ttgatttatt gggaagagtg
    13201 tgtaaattgt gttttgggaa gtgtacttag gtatgttcat ttggagctat ggaaattgat
    13261 aaaaaagtat tatctgttta ttttgctggt aaaatgtgaa tagattatag attatagatt
    13321 atagattata gatttaagta tagactaagt aatttatatt acagaagaga atatataaga
    13381 actagtgcaa gatgtatttg atacatataa aaaattggca aatccagaat aaggatagag
    13441 aaaattgaga ttgaagagtt tgaaagagac ttattagatg aaaaatacaa agatgtataa
    13501 aaatacatat tgagaaagta tatctctctt aaatttgtta ataattctat tatacagaaa
    13561 aacatattta agggggattt tttactatga aaagagtaaa attagctata agctttttta
    13621 tattaatgat tatagggatg acaatatctt atgcagatac aagtataaat actaaataca
    13681 atagattaag taaagctctt gaaatttcag aagcaaattt taaattttat aatgttaaaa
    13741 ttaattctgt tataaatcat aatttatcaa ataaagaatt tcataatatt tttatagaaa
    13801 taattaacaa tctaaagttg gataaaaaag gaataaattg gaatcaaaaa gggtctggcg
    13861 ataaaataca attatgtgct actataaaag gtagcgataa agaaatttct ataaaaggaa
    13921 taaataaaaa taacaaagaa agttacatag tagttgacat attggataac aaagtatata
    13981 aacataaaga ggttatttat agtaacgtag aaaatgtgtt aaataaatat tcatctcaag
    14041 tagatgtgtc tgcttgtatt gttggagaat acacaaaaag gttacaaaac aacaaatatg
    14101 atgatatttt acaaaaaata ttatataata tgagtgctaa gcaaatagat gaagtgaaag
    14161 acgtaaactt tttatctata acagcatata gtaaagtatt aaatgattat gaattagaat
    14221 atttagggga aaaaattaat ttaaatatag gaattaaata taatgaggac gacggaagaa
    14281 cactcatata tattgccaca ccaattataa aattagatta ttaattatga ggagatcaaa
    14341 aaatatggct aagataatag taaaaaagag taatccactt aaaggtagtg ttaaaataga
    14401 tggtgcaaaa aatgcagttt taccaataat agcagcgact ttattagcaa acgggaaatc
    14461 aacattaaat ggagtaccaa atttaagaga tgttcatgtt atatcagatt tattaagaca
    14521 tgtaggggca gaagttgaat ataaagaaaa tacacttact gttgatgcaa gtaatataaa
    14581 aacttgtgaa gctccatatg agcttgtaag aaagatgaga gcttcttttt tggttatggg
    14641 gccattgctt gctagattta atagtacgaa aatttctatg ccaggaggat gcgctatagg
    14701 aacaagacct atagatttac atttaaaagg atttaaagcc ttaggtgcaa agatagaaat
    14761 ggaccatggt tttgttgaag cagcaacaga aaaattagta ggaaataaat tatatttaga
    14821 tttcccatct gttggagcaa ctgaaaacat aatgatggca gcttctttag cagaagggac
    14881 tacaataata gagaatgcag cagaagagcc agaaatagta gatttagcaa acttcttgaa
    14941 cgaaatggga gcagatgtta aaggtgcagg tactaatact ataaaaataa aaggtgttaa
    15001 agagttaaaa ggagcagaac ataatgtaat tccagacaga atagaagcag caacttatat
    15061 ggttgcagca gctatgacaa aaggtgatat aactgttgaa aatgttttaa tggagcattt
    15121 aaaaccagtt gtagctaaat taagagaagc tggttgtgaa ataacagaaa tggacaattc
    15181 tgtaagagtt gtaggtccaa aagtattaaa accaatagat ataaaaactt taccacatcc
    15241 aggatttcct acagatgttc aagcacaatt tatggctatg cttactgtag ctaatggaac
    15301 tggtgtagtt atagaaactg tttttgaaaa cagatttatg catgttgctg aatttaatag
    15361 aatgggtgct aatataaaaa tagatggaag aagtgcggtt gttaatggtg tagatgagct
    15421 acatggtgca gcagtaaacg ctactgattt aagagcaggg gcagccctta ttttatgcgg
    15481 tcttatagca gaaggagaaa ctcaaatagg agaaatatac catatccaaa gaggctatgt
    15541 tgatatagat aagaagataa cagcattagg tggtcaaatc gaaatagtag aagattaata
    15601 attggtttat agaagaaagt tataaattaa tagggttgtt catatactta aatacaaggt
    15661 tttaaaagct aaggaggaga gtatatgaag aacccattgg ttgttttgtt aggatttgtg
    15721 acttgctctg tgttagttcc atcacttata actttagttt cttataaaaa tgtagaatta
    15781 actgaaaaag cagagagccc agtatctata aacaaaacta ttaaaaaaag tgatattgaa
    15841 gacaaaggta ataaagaaga aaaaaataca gtgaactatg aaactgtaaa taaaaaagca
    15901 ccaattatca atgtatataa tcatataaca gggaaaaccg aaaagatgga catggagaac
    15961 tatttatgtg gagtactagc tggtgagatg tcttcagagt ttgatataga agccttaaaa
    16021 gctcaatctg tagcagctag aacatatgta gtatataaac aggaacatgg taaatctagt
    16081 aaacataaaa atgcagtagt atgtactgat tataaacatt gtcaagaata taagagttat
    16141 gatactctta aaaaattaaa tggtgaagaa tggattaaga ataaatattc caaaatccaa
    16201 gaagcagtta gaggaactaa aggtcaaata ataacttata acgataaggc gatacttcct
    16261 ctttattttt ctacatcttc aggaaaaaca gaaaatagtg aagaagtatt ttctgcaaaa
    16321 tatccttatt taaagtctgt ggaaagtcct tatgataagt attcccctaa atttgcgtca
    16381 acacttaaaa taagcaacac agattttgtt aaaagtctta gaagggcata tagcactatt
    16441 gtgatagatg tgaataattt aagtaaacaa gtttcaataa ctaaaagaag tgatgccgga
    16501 actgtagaaa aaataaaatt aggaaataaa gaattgactg gaaaagacat tagaactgtt
    16561 tttaaattga actctgcaaa ctttgacata aaatttggag aaggatacat agatttcgtg
    16621 gtaaaaggat atggtcatgg tgttggtatg agccagtggg gagcagaagg aatggcagaa
    16681 gagggctata aatattatga tatattatca cattactata cagatacaaa aataaaagat
    16741 atatactaat aattgtataa aatgccaaaa acacgtcaat aatccaaatg tagaaatata
    16801 tttggaggtg caaaatgaag aaaaagctgt tagaaaaaga tggtttttat ttatctttgt
    16861 ttgtatgtgt ttgtttatta gcagtaggtg gagtttggtt tacaaataat aatgtagata
    16921 aattggcttc taataaagga attatggaaa atgctaataa agatagtgaa gaggaaatac
    16981 atttaattga aaaagacaag aaagatgcta tccctactgc aacggattca aaacaaaact
    17041 tagaaaaagc taagtcaaaa gaggaaaata aatcgagtac aacaaaatta aattacattg
    17101 gagataaagt aataagagga tattcagaaa aagaacctag ttattctaaa acacttgatg
    17161 tttgggaaac tcataaaggt gtagatatta gttgtactaa aggcaaagaa gtaaaatctc
    17221 tattaaacgg aatagtagta gatgtattta atgatgaaga atatgggcaa tcagtcaaaa
    17281 taaaaagtga caataacatt gtagtagtat attcaaatct agataaaaat gttagtgtta
    17341 agaaagaaca gaaggtaaca gaaggacaat ctctaggtac tgtaggtagt acttctcaaa
    17401 tagaaagtga agaaggtata catgttcatt tagaggcgta tagtggagaa aaatctatag
    17461 acccaatgag tctaattaag taaaagtata acaagtttaa tcatatttgg ttaagcttgt
    17521 tatatttttt ggtgttttta catatatatc attaaagcta ttatgtgagg ggggtaatct
    17581 ttgagatctc atatagagga aagggccata gtggtagcaa aatatatact tgaaaaaaac
    17641 actacagtaa gacaaaccgc caagacattt ggagtaagta aaagtacaat tcataaggat
    17701 gttacagaaa gattgaagga aataaatcca tcccttgcca aagaagttaa aaatgtgctg
    17761 gacaaaaata aatcagagag acatattaga gggggattag caacgaaatt aaaatatgag
    17821 aaggaacata aaaaaatgta ggttaaaaac ctactttttt tatttaatta aattataaaa
    17881 agaaatatat taagtaatta taaatagcaa aataataata ctctcaaaag atttattttc
    17941 tcttgattaa agcgagattt ttgtatatgc tttattatag gagtattaaa ataggcttat
    18001 aatataatct aatattataa ataaaggagt tgaaaaaatg gctggagctg atataggcat
    18061 agatttaggt actgcaaatg tgcttgttta tgttagtggt aagggaatcg ttttagaaga
    18121 accgtctgtt gtggcgatag acaacagaac agattctgtt ttagctgtgg gagaagaagc
    18181 taaaaagatg atagggagaa caccaggtaa tatagtcgct ataagacctt taagagatgg
    18241 tgtaatttca gattatgatg taactgagaa gatgttaaaa tcttttatag ataagatagt
    18301 tgataaaaag ggatttggaa gattttttat gccaagaatt atggtatgcg taccaacagg
    18361 tgtcacagaa gtggaaaaga gagcagtaga agatgctacg agacaagctg gagctagaga
    18421 agtatatata atagaagaac caatagcagc agccatagga gctggtgtag acatatcaca
    18481 gcctaatggt aatatgatta tagatattgg tggaggtact gtagatatag ctgtaatatc
    18541 tctaggagga gctgttgtaa gtgaatctat aaaggttggt ggagatagat ttgatgatgc
    18601 tatagttaaa tatatgaaaa aacaacacaa tcttcttata ggagaaagaa cagcagagaa
    18661 aatcaagttt gaaataggtt ctgcatttaa gagagaagaa gaaaaatata tgaagataac
    18721 aggaagaaat ttaattacag gacttcctag ttctataact ataaattcaa cagaaatgtt
    18781 ggaagcactt agagaatgtg ttgagcaaat agtagttgct actcatgctg ttttggaaaa
    18841 aacgcctcct gagttagcag cagatatagg agatgttggt ataataatga ctggaggagg
    18901 ttcattatta tatggattag ataaaataat agaacagaga acaggaataa ctgttacaat
    18961 agcagatgaa ccattatctt gtgttgcaaa aggtacagga atagctttag gttcaataga
    19021 cctacttgaa actggcgggt ctttcaaaag aaaataatta ggagagttta gaatgttaaa
    19081 tatagatgaa ataaaaaaat taataccaca tagatatcct tttttattag tggacaagat
    19141 tacagagcta gaagttggga aaagagctgt tggtataaag aatgtaacag ttaatgaacc
    19201 atttttccaa ggtcactttc cagaatatcc tttaatgcca ggagtattaa tagtagaagc
    19261 tttagcacaa gtgtgtggag tggcaatgat gtctgtagag gaaaacaaag gaaaactagg
    19321 tgtatttgca ggtatagata aagttagaat caagagagaa gtaagaccag gagatacatt
    19381 aactatggaa gttgaaatga caactcttag aagaaatata gccaaggcag atgctaaggc
    19441 atatgttggt gaagaacttg tctgtaaagg ggaattaatg tttgccttag tagaaaaata
    19501 aaaacttgaa atataaaagt aaaaaggtag ataatttgga gtatttaatc agatactcta
    19561 aaatatctac ctttttatat aaagaatttt atcatttagt ttatatttag attaggtgga
    19621 tactaataaa gccaaggcta ttgtttcagc taagtctaat ataaagctaa gacgtatatt
    19681 attaaatgaa agtttattat tttcatcaat tttatctaca attcctacta tagaataatt
    19741 tcctatttga ggtagttttt tgccaacacc ttttccgggc aggataggtc cttctctaat
    19801 ctgtatatta cctatgttac tctgcgaccc caagcaagca tctatagcca agaagttacc
    19861 ttgtatatgt gtatttttta tagtatctaa agactcatat atatttaagg cgtgaatagg
    19921 gttatctagt gtaccgtaaa cggggtattt aaagttactg ttcttaagta ttgttccaac
    19981 taaagggcct aaagtatcac ctatagccct gtctgttcct atgcaaacaa caatcgtatt
    20041 ttcattaatt atagttttta gaactgaact tagcatctgt ataacatcat catcgctgta
    20101 atttacttta gctaaataca ataggaacac ccccttcaaa aaaatatatg aataaaaagc
    20161 attaaaaaga cctaacttta aatttcagat agatagaaaa ttttatttgt cttacaaaaa
    20221 aaggaataga aaaaatatga ctaaaaatat tgacaaaatt ttaaaaaaat agtaagctag
    20281 taaagtaaaa caaaacttaa atcttgatta ccttatcaag agaggctgag ggataggccc
    20341 tgtgaagccc agcaaccacc caaatgggaa aaggtgctaa ttcctacaag acaaaagtct
    20401 tgaaagatga ggtcagttaa ttagtatgta attacgatta ttaacctctt cttataaagg
    20461 agaggttttt tattttgagt aaatttctaa aattaaaaat aaggtaaaac ctataataaa
    20521 aactaagaat aaataagggg gaataaaaat ggcaagacat ttatttacgt cagaatcagt
    20581 tacagaagga catcctgata agatatgtga ccaaatatca gattcaatat tagatgcatt
    20641 attagaaaaa gacccacaat ctagagtagc ttgtgaaact acagttacta ctggtttagt
    20701 tttagtagca ggagaaataa gtacatctgc ttatgtagac attcctaaat tagtaagaga
    20761 aacagtaaga gaaattggat atacaagagc aaaatatgga tttgattgtg atacttgcgc
    20821 agttataact tctattgatg aacaatctgg agatatagct atgggagttg atgaaggcct
    20881 agaaagtaag actggagaag agatagaaga agaaatagaa aaagttggag ctggagacca
    20941 aggtataatg tttggatttg catgtaatga gactccagaa ttaatgcctc ttccaatatc
    21001 tttggcacac aaattatcaa gaagacttac agaggttaga aagactggtc tagttgatta
    21061 tttaagacca gatggaaaaa ctcaagttac tgttgaatat gaaggaagta aagctgtaag
    21121 agtacataca gttcttatat cagctcaaca ttgtgaaaca gtatcaaatg ataaaataag
    21181 agaagattta attaatcatg ttattaaaga agttatacca gcagaattac ttgatgaaga
    21241 tactaaaatt tatataaatc caacaggaag attcgttata ggaggaccac aaggagatac
    21301 aggtcttaca ggaagaaaaa taataataga tacttatggt ggatattcta gacatggtgg
    21361 aggagctttc tcaggaaaag accctacaaa ggttgataga tctgctgctt atgcagctag
    21421 atatgttgca aaaaatattg ttgcggctgg tcttgcagac aaatgtgaga tagaacttgc
    21481 atatgctata ggtatagcta gaccattatc tatatttata gatacttttg ggacaggcaa
    21541 agtttcagaa gaaaaacttg ttgaattagt aaataaacac tttgatttaa gaccaggagc
    21601 cataataaga gacttagatt taagaaagcc tctttataaa aaggttgctg cttatggtca
    21661 ctttggtaga actgatatag atttaccttg ggaaagaact gacaaggttg agcagttaag
    21721 aaaagatgct ttaggtgaat aatttttaac taaaaagctg ttagaatgta attttacgat
    21781 tactttctaa cagctttttt attatgagtt aaatattttt aataaatgtt aatttatcat
    21841 catataatga ataaacagta tttaatctgg tcaatacatt ttatataata ctatactaaa
    21901 tttatgcata ttatgggata tatgttaaag gatggttaag aatgtgttaa ctaatgttaa
    21961 ataattaaaa atatattgaa atatcataat aatgagtcta atataatctt aataaactta
    22021 cactttaaaa ataattttaa ttggggggag tagtgtatgt caggcaaagt aaatattaaa
    22081 acggttataa gttttgctgg agcttatgtt gctactgtaa taggttctgg atttgcaact
    22141 ggtcaagaaa tactgcaatt ttttacattt tatggatatg ctggtattat aggtggaata
    22201 atctctatgg tactattttc atggtttgga gcagaggtta tagataaggg aagagaattg
    22261 aaacttaagg agccaataaa aatttatcaa gtatattgtg gaaaatatct tggaacattt
    22321 tttgaatggt ttggtccatt gtttttattt ggaacattag taataatgat tgcaggagca
    22381 ggagctacat tatcagagta ctatggatta aatccatatg taggtaggat tggtatgaca
    22441 atcgtttccc taataactgt ttcattaggt ttgacaaggc tttctaaaat actaggtaat
    22501 ataggaccta taataataat atttacactt ttagtaggag caattagttt atttagcaat
    22561 attgatgctt tatcaaatgc tggaaatatg gttgatagtt taaatattaa aactgctaca
    22621 tcaaatggat atttctcagg agtactttat acttgttata atgtaataat agtaataaca
    22681 ttcttgacag gaatgggagc ttctgcagta aataagaaag atgctgtgtg gggtggtata
    22741 gtaggtggag tagcacttat ggcagcagct ataatgatga atttggcatt actttcagac
    22801 ataggaaata tatacacaaa agagatacca gcactttact tagctgataa gatatctcca
    22861 ataataggta ttttattctc agtagtactt ttactaggaa tatacactac agctgtacca
    22921 ttgttatggt cagtaactaa ccgatttgta gaagatgacc accctaaatt taaaattata
    22981 acaatagtag taagtatatt agcttgtata ggaggtctac tgccatttga taagttagta
    23041 ggtacactat atccatatac aggttacatg ggaattttaa ttttactatg tatgctttat
    23101 agaagaatta ctaaaactga ggggtacaag gagaataaat ctgaaataag ctagtactgt
    23161 aatatactta tgaaatttaa tttatactct aaatatggag taattaaaat aaaatagcta
    23221 tttaaatatg gtacctgtat ttcatggtac catattttat ggatgcagat tttttttgtt
    23281 tctgataaaa tgtataatag ttggaaatta cgttaagtat aaaaatataa aacttttcta
    23341 cgattatcat agttttaata tataaaatta tactaacatt taaatggagc gattattagt
    23401 atttttagga gataaaaatg gaaaaattag aaggaatgat aagtgaaata gtctttaaaa
    23461 acgaagataa tggttataca atagctcatc tggtaaatga aaatgatgaa attgtcgttg
    23521 taggatgtat gcctactttg gcaattggag aaagcataga agttgaagga aagtgggtaa
    23581 accataagat ttatgggact caatttgaag tgaatagttt tatgccagta acaccatcat
    23641 ccttagaagg aatttatgtt tacttatctt ctggaatgat acatggtatt ggtgaaaaaa
    23701 tggctaaaag aataattgat aagtttggtg tagatacgtt agaggtgata caaaattcac
    23761 cagaaaaact acaagaagta gaaggtatag ggagtaaaaa agtaaaacaa atagtaaaaa
    23821 gttatgaaga agacagagaa ttgagaaata taataataca gctatctcct tttggaataa
    23881 caccaaatta ctgcctaaaa atatataaaa aatataaaag cagtgcaata gaagttataa
    23941 ataaaaaccc ataccaactt gctgaagata taagaggaat tggatttaaa gtagctgata
    24001 gtatagcaaa taaaattggt atagataaaa attctaagga tagaatttgt cagggaatct
    24061 tatacacttt aaataaatct ttaagtaatg ggcatacata tttaccagag catgttctaa
    24121 tacaagattc ggaaaaatta ttggagctaa atggagaaat aataaaagag tgtgtaatga
    24181 tgctagttta taatcaaaaa atacatgtag agaaagtaaa caatgaaaat cttatatacc
    24241 ttatgccata ctatttagct gaaaatggag tatgtagtca aatagtaaaa ttatcacagt
    24301 atgaatttga agacttaaaa atagatatag ataacgagat taatgtttta gaagaagata
    24361 agaaaattaa gttagcagaa aaacaaattt tagcagtcaa agaatctgtt aatagtggcg
    24421 tattaattat aaccggtggt ccaggaactg gtaaaacaac taccattaat gctatcatag
    24481 atatatttga aaataatggt aaaagcgtga ctttggcagc tccaacggga agagcagcaa
    24541 agagaatgag tgaaacttct aataaagaag caaaaactat acataggttg ctagaaatgg
    24601 gattttcaac agatgatgat ttaacttttt ttaaggatga agaagaccca ataaattcag
    24661 atgtaataat tgttgatgag gtatcaatgg tagacattat cttaatgtac aatttactta
    24721 gagctataaa gttaggaaca agagtaattt tagttggaga tagtgaccaa ttaccttctg
    24781 taggtgctgg aaatgtactt aaggatatga ttaattctaa tattataaat gtagttaaat
    24841 taaatgaaat atttagacaa gcgcaagaaa gtatgataat tgtaaatgcc cataagataa
    24901 acaatggaga accactttat ctaaatacaa aaggtaaaga tttctttttt ataagaaaat
    24961 caactaatga agaaatttta aatgaaataa taggattggt taatgaaaga ttacctaaat
    25021 tttataaagt tgataaatta aaagatatac aagttttatc ctcaatgaga aaaggtgaat
    25081 tgggagttac taatctcaat atagagttac agaagtatct taacaaaaaa gaaaaattta
    25141 aagttgaaga aagtttttct aaaagattat ttagagttgg cgataaggta atgcaagtaa
    25201 aaaataatta tacaaaaaaa tgggaaacag aagaccaaaa agaaagtgga gaaggtatct
    25261 ataatggaga tataggatat gtttatcaca tagataaaga taaaaaaact atttatatat
    25321 tatttgacca gactaaaatt gtatcatacc tatatgatga attagatgaa attgaccata
    25381 gtttttgtac aacaatacat aaaagccaag gaagtgaatt tccagttgta gtattgccaa
    25441 tagcttgggc tcctcctatg ttacttagcc gtaatttatt atatacagca gtaacaagag
    25501 caaaaaaatt agttgtatta gttggagatg tgaaatatct tgaatatatg ataaaaaata
    25561 atagagttaa tcaaaggtat tcaaatttag gatataagct aaataaattt aagcaagaag
    25621 ggctgttgat agaataaata tgaaaatatg caatgataat tttattaaga attttaaaaa
    25681 tatgattaat aaatgtttgg attttatata tcctgagaat ataagttgca taatttgtga
    25741 taaatccata aagaaaacaa atacttattc aatatgtaaa agttgtttta aagaaatgaa
    25801 ttttatacaa gatggttgca tgaagtgtgg aaaaccaata atacgtcatt caattgaaaa
    25861 agaatttatt gaagaatgta gttattgttt taataaagac ttttattttg ataaatcaat
    25921 atcttgtatt gaatacaatg atgtgacaaa aaagatagtg ctagggctga agtataacca
    25981 aaaaaccttt atggctaagt atatagctca aataatgaaa gaaaaattat atttagaaaa
    26041 cataaaattt gattatatat tatttgttcc acttcataaa aaaaggctaa ataaaagagg
    26101 ttttaatcag gcacaaaaaa tagcatttaa tttaagtaaa atagtaaata ttccattatt
    26161 ggattgtata agtagaaaaa aatatacaag aatgctatat aaattgaata agaaagaacg
    26221 aaaagaagaa ttaaaaaatg tatttgttgt taaagacaat gttaaattaa taaataataa
    26281 aaatatactt ttaatagatg atatatttac tactggtcta acaacaaacg aaatttctaa
    26341 acttttaaag ttatcgggtg ctaataaggt ttttgtattg actctactta caaaagcaaa
    26401 tgataattat attatggaat aatcttatat attgacaatt ttaatttaaa atattaaaat
    26461 gaataagtga tatttaggtc tgtggttgaa agtccaagcc agtcgcaggc aaagggatcc
    26521 acgtaagtta acactaaaaa ttgggttaat gatcatggtg cggcttagaa gtaagaccta
    26581 ccgataataa aatcgagaga gagtagtagt gcggcgaacc caagcgaacc ctccagtagg
    26641 cgagtgtggg gtcaaaaacc aggtcagcta aatatcgtat taaaagggag ctagcatacc
    26701 tttatgtata gctctttttt atatataata aatttaggtt gagtcataaa gaggtgatat
    26761 gtttgaataa aagacaggaa aacttattaa caacgttgct attaaaagaa gagtttataa
    26821 atgttaataa gattgccaat gattttgagt gttcagaaag gacaataaga aatgattgca
    26881 aatatattga tgaatggtta tctacttttt gtaatgctta tatcaaaaga aaacctaata
    26941 ttggaattaa atttagtgga gatggaacag acaaaatact ggtaaatcag aagttgcgag
    27001 gtgaagttaa aagagtaaat agtgagcttc ataagcaagt tgagatatta aatttactac
    27061 tttgtaataa taaaaaagtt actttaaatg atttatctaa taagttgtac ataaataaaa
    27121 atattgtcag agaagaaata agtaaattat cagtggcatt aaataattat aatttaaatg
    27181 tctcgactaa aaaaggcagt ggtatatata ttggagggga tgagaaagac ataagaataa
    27241 tgttagtatc attcttattt aaatacatag ataaatacag attaaacata gatgaaatag
    27301 agtacttcca tatagtagat ataataattg taaaaaacat aatgtttact atagaggagg
    27361 atatggatat aagacttaca gatatatcat tcaagcaatt gatgctattt ttacttataa
    27421 atataatacg aataaggcta ggaaattctt taaaagtatc aaatactaag aaagagctta
    27481 agctaaaaat gctgatatta gatatagaag atgaattgaa atctaattta tccatagtat
    27541 taaattatga agaaaaattg tttatagagt ctttaatatt gggtatgaac aaacaaataa
    27601 atagtagtaa tattaagaaa tctttatatc taaatgaaga attagcaagt tatacaaaaa
    27661 aaattataaa tttagtatca gaagaatccg gaataaattt taataatgat atattacttt
    27721 atgaacaatt aatatgtcat ttgaatgtta caatgcacca aatgaaaagc aatgtttact
    27781 tagaaaatcc acttttagat aacataaaaa ctaaattttg ttttttattt acagtaatat
    27841 caagttcaat agaaattgaa ttaaaaggaa aacaaataac agaagatgaa attggttatc
    27901 ttacacttca ctttcaaacc tctctagaaa gaaaatacag caaaagggaa tcaaataaaa
    27961 aggcaagtat tgtatgtcca tttagttttg gagtaagcat gctattaaaa gtaaagatag
    28021 aaaagagatt tgataacata aaaattattg aaacattaag agaggaagat ttaaaaagag
    28081 ataacttcaa taagactata gattttataa ttgcatttca agagtatgaa aatatccaaa
    28141 aaccaatttt tataacaaca ccattattta ctgatgagga tgagaataaa cttaaagagt
    28201 tcacaaacaa aataaaagaa aaagacactt catataaact tatgaacaga ttaatgatgt
    28261 ctgattattt aataagagag ttagaacatg atgatattta tgaagctata acatatttaa
    28321 ctaatttatt aattgaaaaa cattatgcag aaaaagagta tttacaatct attataacaa
    28381 gagaaaagtc atatccaacc aatgttggaa aaggaatatt attccctcat ggagatatga
    28441 aatatataaa acaatctgtt ttatgttttg caaggttaaa aacaccaata agaattagaa
    28501 atggaaagga tataaagatt atacttttgt tagcatataa aaaagatgat gatagaaaag
    28561 tatttagaga attatttaaa gaaatatcta atttaacaga ggatgaaaat atgctagata
    28621 ttctaagtaa atgtgacatt gaaaaagtaa aagatattct tatataaaat tcatagtgaa
    28681 ctatggataa gcacaaaatt ttccatgtga tggaaaaagt tgtgcatgtt tttttgtttt
    28741 tataagatat tatatgtttg taaggtataa ataatctaaa agtagagaag caacttagga
    28801 ggaaaaaatg gaagaaatag ttttaaagat tataattcat gctggaaatg caaaatctat
    28861 gctttatgaa gcacttgact atgcaaagga aaacgatttt aaaaaagcag atgaattaat
    28921 tgaaaatgca aatgaagaaa ttttaaaagc acataaagta caaactgaac ttatacaaaa
    28981 ggaagctggg ggagataaat cagatatatc tattttattg attcactctc aagaccattt
    29041 gatgacttgt atgagtgaga gaaaccttat aaaagaaatg attatgttaa gaaaagaaat
    29101 tcaaaaatta aaataaaaaa attaaggggg atttaaaaaa tgaaaagaaa agtatattta
    29161 ttttgtagct ttggtatgtc aacaagttta cttgcagata aaatgcagaa ggtagcagat
    29221 gaacacaatt taccaataga agtagaggca tttccgatag cagaaattga caaaatagtt
    29281 gaagaaaaaa atccagattg tatattacta ggaccacaag ttaaatacat gctaaaggaa
    29341 ttaaaaccaa agtttgaagc tcaaggaaaa cttatagata taatcaatga agttgattat
    29401 ggaactatga atggggaaaa agtattaaaa ctcgctataa agctaataaa atccaaacaa
    29461 gcgtagaatt atagtaaaaa ataataggaa atgagggtag atagatgaat agattggaaa
    29521 gaatacttat gccattggct gaaaaaatag gtaaaaataa attattaatt gcaattagag
    29581 atggtttttt aatatcatca ccattattaa taataggttc attattttta ttagtagcaa
    29641 attttcctat aaaaggatgg aatgaatttg taggtcaaat ttttggttca gattgggctg
    29701 taaaattgca acaaccaact gtagcaacat ttgaagtaat gactctactt gcagttttag
    29761 gaattggata ttcttatgca aagcaaatag atgtagaccc aatagcatca gcagcagttg
    29821 caatagttgc cttttttata ataacaccat ttgtaatacc atatacacca gaaggaacag
    29881 aatcagtcta catggtaaca ggtataccac taggttggat gggctctaag ggaatgtttg
    29941 taggtatgat aacagcaata acctctgtaa aattatttgc tgcagttgta aaaaaaggat
    30001 ggacattgaa aatgccagat ggagttcctc caaccgtatc aaaatcattt gcagcattaa
    30061 taccaagtgc aatagttatg gtagttttct ttttagttaa gatagctttt gaagctacac
    30121 catatggaag tatacatgaa tttatattta agtttttaca aatgccatta ttaaaattag
    30181 gaaatagttt aggtgctatg gcaatcgctt atatattctt acatttattc tggttctttg
    30241 gaataaatgg aagtagtgtt gttggggctg tgtataatcc aatattaaaa attctatcag
    30301 ctgaaaattt agctgctttt caagctggtt caaaaatacc aaacataata acaggtcaat
    30361 tccaagatat gtttgcgaca tttggtggag caggtagtac actatcatta gtcatagcta
    30421 tgttattaat atgtaaaagt aaacgtataa agtcaatggg aaaactatca attttaccag
    30481 gaatatttgg tataaatgag ccattgatat ttggtctacc aataatgctt aacccaatac
    30541 tattgatacc atttgcaata gttccaacaa taaatataat aatagcttat ttctgtatgt
    30601 cagcaggatt agtgcctctt acaaatggag ttcagttacc gtggacaact ccaattatat
    30661 tctctggttt tttaacaaca ggatggcaag gtgcagtctt acaagtagtg cttcttatac
    30721 taggaatatt tatgtatata ccatttataa aaatgctaga taagcaatac ttaagagaag
    30781 aaaatgcaac tgttgaagag gaagatgatg atatatcttt tgatgattta gtattatagg
    30841 aggaagatga tgaagaaaat agttatgata ttggatcaaa tacaagctgg agctggagga
    30901 aaagagaaaa gtaatatacc tcctgctgga aaatcaagcc cattaggacc aggtataatg
    30961 atggagcaat ttttaaatga atctaaggta atagctacct tattttgtgg ggatgaattt
    31021 tttgtaaata atgaagaaga agtaactagt aagatgatag ctatggtaaa aaaattaaac
    31081 cctgatgtag taatctgtgg accaagcttt aattacgaaa acttttctaa gatgtcagca
    31141 atactgtcta aaaatataaa tgataaaaca gatataccag cttttgcagc tatgtcagaa
    31201 gaaaatatag atgtgataaa cgaatataaa aatgacatat gtatagttaa gactccaaaa
    31261 aaaggtggaa ttggtcttaa tgattcatta aataacatat gtaaattggc aaaagcaata
    31321 gcaaataaag aagatataac tttgatgaaa gaagaatttt gttattaata agagtattaa
    31381 ttattagtaa gtttaaatat tatactattt ataataagca tacattagta aaatctatat
    31441 aatttaagga ggggaatttt aacatgtggg gaatgatagc gacatggaga atggccctag
    31501 aaggaataac tgaggcatca gaacatttag aaaaaggcat ggaagcaggt gatgctgtag
    31561 agcttgctgt aagaagagtt gaagactatc cattctataa atcggttgga tatggtggac
    31621 ttccaaatga aaattgtgag gtagaacttg acgctgcatt tatggatggt aacacattag
    31681 atattggagc agttgctggt ataagagatt attctaatcc tgtcagcata gctaggaagt
    31741 taagttatga gaaggtaaat aattttttag ttggaatagg tgctgaagat tatgctcata
    31801 aaaatggatt tgaaagaaaa aatatgttga ctgatagagc gaagttacat tataaaaaga
    31861 gaaaaaaaga gactttagac aaaggattaa gtccatatgc tggtcatgat actgttggta
    31921 tgatatcttt agacaaaact ggaaaaatgt gtgcagctac atcaacaagt ggattgttta
    31981 tgaagaaaag aggtagaata ggagattctg cactatctgg ttcaggattc tatgttgata
    32041 gtagtatagg aggagctaca gctactggtt tgggagaaga tttaatgaag ggatgtatat
    32101 cttatgagat agttagactt atgaaagaag ggaagcatcc acaagaagca tgtgatattg
    32161 cagtaaatga acttgataaa cagcttatca aaagaagggg aaaagctggt gatttatcat
    32221 tagttgccat gaataataaa ggtgaatggg gagtagctac aaatatagct gattttactt
    32281 tttcagtagt aactaaagaa gaatctccta ctgtatatat ttcaaataga gtagatggaa
    32341 agactataca taaggttata tcaaatgagt ggatggaagc atatgaggct agaataaaag
    32401 caccaataga agtaagtgag taaagtagtg gttacataat taaaatagag ttttataata
    32461 aggagatttt tatgaatatc ataagtaata aaatagatga gttaaaagaa gatttattaa
    32521 gtgatattat agatattgta aaaataccta gtgtcaaagg ggagtcagaa aatggcttcc
    32581 cttttggcga aaaagtaggg gaggcactta ataaagcatt agaaatatca gaaaaattgg
    32641 gatttaaggt tagaaacttg gataattata ttggttatgc agagcatgga gatagtgatg
    32701 attatgtttg tgtaattgga catgtagatg ttgtacatga aggagatggt tggaagcatc
    32761 agccttataa gggagaagaa actaatggaa gaatttatgg acgaggagta ctagacaata
    32821 aaggacctat aatgtctgcc ttatatggat tatatgctat taaagaatta aatttaaaat
    32881 tagataagag agttagaata atatttggta caaatgaaga aagtggattt gaagatatac
    32941 catattattt agaaaaagaa aaagcaccta ttatgggatt tacaccagat tgtaaatatc
    33001 ctgttgtata tggtgaaaaa ggcatggcaa agattagaat aaaaagtaaa atcaattatg
    33061 aagaagatgt atacttaggt tttatagaaa atatgtctga aaatgtgctt gttacatata
    33121 aagaactgaa tatagaaaat agtgatacta tattagatat aaaggtaaaa tacgatttta
    33181 gttataaatt gaaagatgta ttggatgaaa taaaagctag ttttccaaat agtatcgata
    33241 tagaggtaat ttctaatttt aatcctgtat attttgataa agagagtaat cttgttaaaa
    33301 agcttcagct agcttatgaa agggttacat cattagatgg aactccagta acaactaatg
    33361 gaggtacgta tgcaaaagta atgccaaata tagttccgtt tggaccttca tttccaggac
    33421 aaaaaggaat agctcataat cctgatgaat acatggatat agaagatata atattaaatg
    33481 caaagatatt tgcaaatgca atatatgaat tagcaaagga gtagttatgt tagaaataat
    33541 aggaatgtca gtagaagacg ctaaaattat agaagattgt ggtgcagata gaatagagtt
    33601 agttagtgct ttaactgaag gtggattgac accaagtttt ggtcttatag aaagtgttgt
    33661 taacagtgta aagatacctg tgaacgtaat gataagacat catgcgaaaa gttttgtata
    33721 cagtaaagaa gatataagta taatgcaaaa agatataagt gtggttaaag agattggtgc
    33781 taatggagtt gtatttggtg tattggataa aaacaatagt atagatgaga aaaatctaaa
    33841 tgttttattg aaatgttgtg ataatcttga tgttacattt catagagcaa tagatgaatc
    33901 aaatacaata gatagtgtta aaattttgaa ggattatgat aaaattacga atatattaac
    33961 atcaggaggg aaaggaagta tagttgataa catacaaatg ataaagaata tgatgcttag
    34021 ttctaatcac ataaaaattc ttttaggtgg aggtcttaat tttaataata tagaaaagat
    34081 aaaggaatta actaaggcaa gtaattttca ttttggtaca gcgattagaa taaataacag
    34141 tccttttgaa gatatagata gacaaaagct taaacaactc gtaaatataa tttcaagata
    34201 gtatatgaat ataaaatact tagtttaaat aaagagagta agttaattat aatttgggta
    34261 tatgaatgtt aataggtatt aaatatgaaa ttattgttga gtatgcttta taacttttaa
    34321 gtagttttaa atataaataa tgaaagaaaa gatagattat ggaggtttta gagggtttat
    34381 atttattaaa aaattataaa ggtatattgg catataatac acataatttc ctaaaattac
    34441 catcttatga catgaattca catattaata aacaattaat ggagattttt gtggatagaa
    34501 ataggagtaa aaatagcttt aaataaacaa aaacaagagt tattaacagt tttatccaca
    34561 ttatccacag gtgtttgtaa taatattaat ccacataagt atcaatgtaa ctaaaaatga
    34621 taaataattc tatcaattga atagaaaaaa tcataaaagt aaataataaa aagaggatta
    34681 tgagagttcg tgtagaatat attattaaag tataaatttt cttatactgg cataattgaa
    34741 gggagatgta tttatgaaca taattatatc tggaaaacaa atcgaattaa ctgatgcaat
    34801 aaaaaataaa atcgaaacta aactaagtaa gttagataat tacattcatc cagacactga
    34861 tgtaaaagtt acagtaagtg cgagaaaagc aagacaaaaa atagaagtaa caatagctac
    34921 tgtaaatggt cctataatta gagcagaaga tatgcaggaa aatttataca cagctataga
    34981 tgttgtatat gataaattaa gtaaacaatt aaaaaaatat aaaaagagat tacaagataa
    35041 acataaagac aacaagagta taagattcca agatgcagag ataaatctag ctgatgaaca
    35101 agaggattat ggggatgaaa atcaagaatt agtaattcaa agacgtaaga aatttagtgt
    35161 taagccaatg agtgaagaag aagctgtatt acagatggaa ttaataggac atgattttta
    35221 tatgttcaag aacatagatt cagatgaaat agcagtagtt tataagcgta ataatggtgg
    35281 atatggtata atagaacatg aataaagcaa tttagattta atcatattag ctatcgataa
    35341 ataaattatc gatagctttt taaattaata ttaaaagtat agtttttatg gtaaaatgaa
    35401 taatagtaca ataaagaacg aggagagatg taaaatatga gctttatgga taatttattc
    35461 aacatggcag ataaaaaaga attaaaaaag ttcaataaaa ctgttgatat aatagattca
    35521 ttagaaccta aatttgaatc tatggcagac tcggaactta aaaatatgac aaatatattt
    35581 aaagaaagat tagcaaatgg tgaaagtata gatgatatac ttccagaagc ttttgcagta
    35641 gttagagaag tttctaagag agtgttagga cttagacact acagagttca aatgattgga
    35701 ggtatagtac tacatcaagg aagaatagca gaaatgaaaa caggtgaagg taaaactttg
    35761 gttgcaactg ctcctgttta tttgaatgcg cttactggaa aaggtgtaca tgttgtaaca
    35821 gtaaatgatt accttgcaaa acgtgataga gaccaaatgg caaaaatcta tgagttttta
    35881 ggaatgagtg taggcgttat tatacacggt caaaatccaa aagttagaaa agaacaatat
    35941 gattgtgata taacttatgg tacaaataat gaatatggat ttgactatct aaaggacaat
    36001 atggtaatac acaaagagca aagagttcaa agaggattaa attatgctat agtggatgag
    36061 gttgactcta tactaataga tgaggctaga acaccactta tcatatctgg acctggagac
    36121 aaatcaactc acttatattc agatgcaaac acatttgttt taaccttaaa accagatgat
    36181 tatgaattag aagaaaaaga taaggctgta tctctaacag catcgggtat acaaaaagca
    36241 gaagtgtatt ttaatgttga taatataaca gatatatctc atacagaatt ataccatcat
    36301 ataaatcaag ctttaagagc acatgtaata atgaagaaag atgttgatta tgttgctaaa
    36361 gatggagaaa tagtaatagt agatgagttc acaggtagac ttatgtttgg tagaagatat
    36421 tcagaaggtt tacatcaagc aatagaggct aaagaaggtc ttaaaataca aagagaatct
    36481 aaaacactag ctactgtaac attccaaaat tattttagaa tgtacaaaaa actttctggt
    36541 atgactggta cagcaaaaac agaagaagaa gagtttaaag caatctacaa aatggatgtt
    36601 ttccaagtac ctactaataa gcttatgata agggaagact taccagattg tgtatacaaa
    36661 agtgaaatag gtaaatttaa tgctgtagca caagaaataa ttgaaaggca caaagtcaat
    36721 caaccaatac ttgtaggtac agtatcaata gaaaaatcag aattattatc acaaatacta
    36781 aagaaaaagg gcataaagca cgaggtatta aatgctaagc atcatgataa agaggcagaa
    36841 ataatagcac aagctggtag acttggagct gttacaatag ctactaatat ggctggtcgt
    36901 ggtacagata tagttctagg tggaaatcca gactttttaa ctaagagaga aatgagaaga
    36961 aatggattta aagaagaaat agtaaataga gtagatactc caatagaagg tatacctgta
    37021 aaaggtaatg aaattctatt tgaagctaga gaagagtatg aaaaactatt tgaaaagttt
    37081 aagcaacaaa cacaagaaga acaaaaacaa gttgtagaag caggtggact tgctataata
    37141 ggtacagaaa gacacgaatc tcgaagaata gataaccagt tgagaggtcg tgctggacgt
    37201 caaggtgacc cagggagttc aagattctat ataggtcttg atgatgacct tatgagattg
    37261 tttggtagtg atagaatatc tggtattgta gataaaatag gtcttgaaga agatatgccg
    37321 atagaacata gaatattatc taagtctatt gaaggagcac aaaagaaagt cgaaggtaaa
    37381 aactttggaa taagaaagca tgtacttcaa tatgatgatg ttatgaataa acaaagagaa
    37441 ataatatatg cagagagaaa acgtgtatta gaaggtgaag atttacaaga acaaatacaa
    37501 tcaatgactc attctataat agaagaagca gttactcttt atacacaaga taaaggattt
    37561 gatgaagaag gatttaaaga acatatgtat aatctgttct tgccaaaagg tagcatagaa
    37621 ataccagaaa tagaaaaact taatccagtt gaaataacag aaaaagttta tgaaatagct
    37681 atgaagatat atacttcaaa ggaagaacaa gttggctatg agagaatgag agaagttgag
    37741 agagtaatct tacttcaagc tgttgataac cattggatag accatataga tgctatggac
    37801 caattacgcc aaggtattgg tcttcgtgct gtaggtcagc aagacccagt tattgcttat
    37861 aaaatggaag gttttgatat gtttgatgaa atgaataaac atatcaaaga agatactgta
    37921 agatatttat ttaatataac aatagaaact ccagtggaaa gaaaagcagt tgtagatgtt
    37981 gaaaatctat cttctccatc agatggaaca cttccaacaa gtaaaactgt taaaaaagat
    38041 gaaaaggttg gaagaaatga cttatgccct tgtggaagtg gtaaaaaata taaaaactgt
    38101 tgtggaagat aatctcggag gattaaatgt taaagttaca agagtataga catagtatgg
    38161 agcagatggc ttcaaattta gaagaattga gggtttctct ttgacatagc ttcattgatg
    38221 aaaaatatac aaattaatga agaaaagatg aataaacaag acttttggaa tgataatgaa
    38281 gtcgctcaaa gagtacttca agaaaataag tctttaaaag agacattaga agaatatgaa
    38341 agcttaaaaa gcttactaga agatatagaa gtattaattg aaataggttt agaagaagat
    38401 gatgattctg tagaaagaga tatagaaaag tccatagaat caatggaaga aaaattatct
    38461 gaaatgaaaa taaagactct tctaaatgga gagtatgata aaaataatgc tatattatct
    38521 ataaatgcgg gtactggtgg cttagatgct caagattggg ctcaaatgct tttgagaatg
    38581 tatataagat ggtcagaaag taagggttat aaagttaagc tcttagatat aatatcagac
    38641 cctgaagcgg ggataaaaac agctacaatt cttgtagaag gaacaaatgc ttatgggtat
    38701 ttaaagagtg aaaaaggagt tcatagatta gtgagaatat ctccatttga cccatcagga
    38761 aaaagacata cttcatttgc atctatagat gtaacaccag agttagatga aaatatagaa
    38821 gtagaaatta atccatcaga tttaaagata gacacatata gagcttctgg agctggaggg
    38881 caacatgtaa atacaactga ttcagcagtt agaataacac atatccctac tggtgtagta
    38941 gttcagtgcc aaaatgaaag gtctcagcat ctaaataagg acagagctat gagactttta
    39001 atggcaaaat tgatagaatt aaaagagtta gaacaaaagg aaaaaataga agatatacaa
    39061 ggcaaatact cacaaataac ttggggtagt caaattaggt catatgtttt tcaaccatat
    39121 aaattggtta aagaccatag aacaaatgct gagtttggaa atgtagatag tgtaatgaat
    39181 gggaatatag acttgtttat taatgaatac ttaaaaatga ataaaatagt ttaataaata
    39241 tgcactgtaa ttaagatata tgtataagaa ggttagtgct taatatgcac ttacagcact
    39301 taggctgagg acgataaccc tcagccttcg ttctgttttg ttatacttat gaaaaactaa
    39361 cattaggagt gaataaattg gatataaatc aaattttaaa aaaagagttt aatcttagag
    39421 atgaacaaat aaataataca ttaaaactta ttgatgaagg aaatacaata ccatttatag
    39481 ctagatatag aaaagaaatg actggcgaaa tgagtgatgt tacactaaga gaattttatg
    39541 aaaagttaat gtatttgaga aatcttcaaa gtagaaaaga tgatgtagtt agactaatag
    39601 atgaacaagg taaattaaca gatgaaataa cacaaaatat agaaaaagca aaaacactac
    39661 aagaagtaga agatatatat gctccatata aacaaaagaa aagaactaga gcaacaatag
    39721 caaaagaaaa aggattagaa aaattagcat tgtcaatact agagaataat ttagataata
    39781 tagaaataga ggcaaagaat tatcttgatg aagagaaaga agttctttct attgaagatg
    39841 ctctaaaagg tgctagagat ataattgcag aactagtctc agatgatgct aagattagaa
    39901 agtatataag agaattagct ttaagagaag gtatgatagt tagtaaaagt gccactgatg
    39961 agaaatcggt ttatgacatg tattatgatt atagtgaagc agtaaaaagt atgcctccac
    40021 atagagtttt ggcaataaac agaggagaaa aagaaaactt cctaaaggtt aagttagaaa
    40081 taaataatga taaagtttta aattacataa taaacgaata tgtaaatgat aaaaatttca
    40141 aaaataaaga agaaatcgta agttcaatag aagattctta taaaagatta attttcccat
    40201 caatagaaag agaaataaga aatcatttaa cagaaatagc tcaagaaaga gctataagtg
    40261 tatttggaaa gaatgttaaa agtttattgc ttcaaccacc agttaaagac aaagtagtta
    40321 tgggatttga ccctgcattt agaactggat gtaaaatagc tgtagtagat aaaaatggta
    40381 aactactaga ttatacaaca gtatatccaa cagaccctca aaatgatgta gagggagcaa
    40441 agaaagtttt aaaaggattg attgaaaaat acgatataga tataatttca attggaaatg
    40501 gtactgcatc tagagaatca gaaacttttg tatcagaaat gataaaagaa atagataacg
    40561 aagtgcagta tgtgatagtt agtgaagcag gagcatctgt ttattcagcc tctgaacttg
    40621 caaatgagga acatccagat ataaatgtat caataagagg agctatatct atagctagaa
    40681 gattacaaga cccattagca gagcttgtaa aaatagaccc taaaagtatt ggcgttggtc
    40741 aatatcagca tgatttaaac aaaaagagat tagaagaagt actagatgga gttgttgaag
    40801 attctgtaaa tagtgttgga gtagatttaa atactgcatc atactcccta ctagaacatg
    40861 ttgcaggaat aagtaaaact atagcaaaaa atataatagc atatagagaa gaaaatggag
    40921 attttacgtc aagagcacaa ttgaaaaaag taaagagact aggaccacaa gcatttactc
    40981 aatgtgctgg atttatgaga atcttagagg gtaaaaatcc actagataat acaggtgtgc
    41041 atcctgaaag ttatgatata tgtaaaaaaa tgattgagat aattggatat tctttagatg
    41101 atgtaaagaa taagaatata tgtgaaatag atgaaaaaat aaaagaaatt ggcttgagag
    41161 aattaagtga aaaactggaa gtagggcaag ttacgttaaa agatatcata actgaaatca
    41221 aaaaaccagg aagagaccca agagaagaag gtataaaacc tatacttaga actgatgtct
    41281 taaaaattga agatatacaa gagggtatga ctttaaaagg tacaataaga aatgttgtag
    41341 attttggtgc atttgtagat attggaataa aaaatgacgg attagttcat aaatcagaaa
    41401 tgagtaatag ttttgtgaaa gaccctatga gtattgttac agtaggtgat atagtagatg
    41461 taaaagtcat tggaattgac ttaaacaaaa aaagagttgc cttatcaatg aaaaaataga
    41521 taagtttatg tatggttata gtacttaaat tctatgtttg taaatgaggt tactcgagtg
    41581 tataaatgtt aaaaatttgt aaaagtatac agtaagaaaa tatattaaaa taagaacgat
    41641 agtcttgaaa atcaggagga aaatgaatga tttttataaa aaatggtaaa ataaatacca
    41701 taacaaatgg gataattcat ggagatatac ttatagatga aggaaaaata atagaaattg
    41761 gagaagattt gatagctcct ttagatgtag aggtaataga tgctagtaat aaacttgtgt
    41821 ttcctggatt tatagatgct catactcatt taggtttgtg ggaagatggt atagggtttg
    41881 aaggagcaga tggaaatgaa gagactgacc caataacacc acaattaaat cccatagatg
    41941 gaattaatcc aatggataga acttttaaag aagcttttga aggtggaata acttctgttt
    42001 gtacaacccc tggaagtgca aatgttatgg gtggtcaatg tatagctata aagacatgtg
    42061 gaaaaagaat tgataaaatg gtaataaaaa atccagttgc atctaaaatc gcttttggag
    42121 aaaatccaaa gagctgttat ggtcaggatg ataaatctcc tcaaactaga atggctatag
    42181 ctgctttact tagagaaaac ctaaaaaaag cagaagaata tttagaggat attgatatgt
    42241 atgagagtca tgatgatgaa gactgtgaaa aacctgaata tgatataaaa atggaaagtt
    42301 taataccagt tttaagaaga gaaattcctt ttaaggcaca tgctcataga gcagatgata
    42361 tgtttacagc aataagaatt gcaaaagaat ttaatttaaa gcttacatta gaccattgta
    42421 cagaaggtca tcttattgta gatgaattag tggaagaagg gtttcctgta atagtagggc
    42481 catctttgtc agaaaggtct aaatttgagc ttagaaattt gacatttaat acagcaggaa
    42541 tactttcaaa tgcaggtctt gatgtatgta taatgacaga ccatccagta ataccagttc
    42601 aatatcttcc aatatgtgca ggtattgcag tcaaacatgg tatgaaagaa gaaaaagcaa
    42661 tagaatcaat tacgataaat ccagctaaga ctttaggaat agaagataga gtaggctcta
    42721 tagaagttgg taaagatgca gacctagtaa tttgggataa ttctccacta gagattcaaa
    42781 gtaatgtact ttacactata ataaatggca aagtagtgta tgagaaaaaa taacttgaca
    42841 attattaaaa aattaactaa tataagagtg taaggaaaat taaaaaatca aagaagatct
    42901 tcggggcagg gcgaaattcc ctaccggcgg tatagcccgc gaactactta agtggttgat
    42961 ttggtgagat tccaaagccg acagtaaagt ctggatgaga gaagatattt atggaagata
    43021 aataagttta ttttagtttg tttaaactat atccataaaa actcgaagat agggtcttcg
    43081 agttttttgt ttttcctaaa aaatataaac atattgatta gggggaaata attatgcaaa
    43141 acacagccaa aagaggcaat atgatttcaa caagaacttt agtagtaatg tcaattttat
    43201 ctgcaatatc ttatttatta atgtttattc aagcaccaat accaggtata tttccagatt
    43261 tcttaaaaat tgacttatca gatattccag caatattcgg aggaatgtct ctaggaccat
    43321 ttgttggatt tggaatagtt gtagtaaaaa atgtgttaca agcaataaca gcaacaacaa
    43381 ctggaggaat aggagaattt gcaaatatat taattggtgg ttcttatgta atgatacttt
    43441 gttattcata taagagaagt ggagatttaa aaggtgtatt gattggtttt gtattaggaa
    43501 caatatctat gactataatt ggttcattag taaattattt tgtaatgttg ccactttatg
    43561 gtcaacttat gggactagat gctataatag gtttaggttc agctataaat cctcaagttc
    43621 atgatttatt cacttttgta atttggatga tagctccatt taatgtgctg aaggctgtta
    43681 tactatcttt agtaacattg ccactttata aaaaaatggg aaatgtaata aagaaataat
    43741 tagacaagaa aatataaaat taaatgtatt gaatagccat aatttattta taacttcagt
    43801 cctatattgt gattgatata ttaaatatat tatggcttta ttaatttatc aaaaaatgta
    43861 tataaaataa gaaatattta gacaaattta aattttaaaa taaaggaaga attaaaacga
    43921 ttaactatta aaatatgaaa aaggtatctg caatatacag agcgaattta taataaataa
    43981 aaaataaagt tattattaaa aaaatataaa gattagtaat caaattttta ataataacta
    44041 atttaataat gatgggagtg tatattcatg aacttatcta aaaagataaa aaaattattt
    44101 ttagatgata aagggtatta ttttaatagt aattggaaag atattcatat tggtatttat
    44161 aatacaaaat taggagattc tttaaagtat atcactaatg aatatattga aaatctggaa
    44221 agggtaaaat atgactatcg tgaattaaaa aatatagaaa atcaaactga tggtatgtgt
    44281 attttagcaa taaggcagaa ttacaaggca ttagagtatg taaaaaatca aaccgaagaa
    44341 ttatgtttag aagcaataaa gtataattat aaagcacttg aatatgtaaa agagcaaaca
    44401 gaatatatat gtcttgaggc tataaaaaag gattgtaatg cacttaagta tgtacgaaat
    44461 aaaacagaaa ggcttattat aaaagtaata cgtcattctt ccaatataga tgttgtaagt
    44521 atactaaagg ctttagagac tcaaacaaga agaatatgtt tagaagcaat taaaaaagat
    44581 ggcaggtgtc ttgcatacgt tagagaacag agtgaagaat tatgtataga ggccattaaa
    44641 caaaattata aagcattaaa atatgtagaa aatcaaacgg aaaaaatgtg tatagaatcc
    44701 gtaagacaaa atggtatggc attacaatat gtaaataaac aaactgataa aatatgtata
    44761 gaagctgtca aacaagatgg aagaagtcta caatttgtca ataataagac agaagaaata
    44821 tgtataaatg ctataagata tttaaataaa aaatataata ttaaagatgt actaagttac
    44881 atagataagt atacagaaga tatatgtata gagattgtaa gacaaaatgg aaaaatgctt
    44941 atgtatataa aaaatcaaac agaaaaaatg tgtattgaag cagtaaaaga gaactataag
    45001 tctcttaagt atgtaaaaga gcaatctgag agaatatgta aagaagcatt gaagcaaaac
    45061 cataaagcaa aagagtatgt aaaaattgct attgatgatt gtatataagg tgtagataca
    45121 gccatcaata gtgaaagata aaaaaagata aagacaagta ctttataata atctaggctt
    45181 atactataat taattaagca gtgatataaa ttcacatgac gattatatca aaatggagat
    45241 gaattgatgg caaaaatata tttagaaaat gaaaataaaa ctagagaaat aggatataaa
    45301 ttaggtaaac ttttaaaaga aggcagtgtt atctgtttag taggagattt aggagctggt
    45361 aaaactacaa tgacacaaag cttggcagat tcattaggga tagaagatta tataacaagt
    45421 cctactttta ctataataaa tgaatatgaa ggaaaaatac ctttgtatca ttttgatgtt
    45481 tatagaatag gtagtagtga cgaaatgtat gatattggtt atgatgaata tgtaaattca
    45541 aatggaatct gtataataga atgggctaat ctaatagaag atatacttcc aaaagaatat
    45601 ttgaatatag aattgagata taaagatgac ggaagagaaa tgatattaac tccaaaagga
    45661 gagttttata aagagatagt tgaggagttg attaaataat gaaaatacta ggtatggata
    45721 cgtcttctat ggcagcaagt gtagcagttg ttgaagatga taacttaata tgtgagttta
    45781 cagtaaacaa caaaaaaact cattcacaaa agcttatgcc aatgatagaa aatatgttga
    45841 gtatgagtga tttaagtata aaagatatgg atttattagc tgtatgtata ggtccaggct
    45901 cgtttactgg acttagaata ggtatggcca cagtaaaagc tatggctcat gtaaataata
    45961 taccaataat agcagtaaat tctttggaat ctctagcaaa taacataaat ttctgtgata
    46021 gaaagatatg ttgtatatta gatgcgcaga aaaatcaagt ttattcagct aaatacaagt
    46081 ttgaaaatgg agagatgata gaattagatg gtgtagatgt tgtagagttt gatgctttag
    46141 tagatgaaat tgtatcaact aatgaagaat ttataatagt tggagaagct gtatacaaat
    46201 ataaagataa gttagagaat ataaaaaata taaaaatacc ttcaccagct aataatgtat
    46261 ctaacgcagg aagcttatgc tctttagcat taaataaata taataaaaat atagatgtac
    46321 atacttgtta tacgataaat cctatgtata tcagaaaatc tcaagctgaa gtacaatatg
    46381 atgaaaaaat gaagaggcta aataatggaa gataatacaa aactaatagt agatgatata
    46441 aaaatagaag aaatgactac agaagatata gatgaagttt ttgaagtaga aaaaaattgt
    46501 tttgaagatt attggtcaaa agagtctttt agaaaagagt tgtctaatga agtagcaagg
    46561 tatatagtag ctaagttaaa tggaaaaatt gtcggatatg tgggaatttg gcttatactt
    46621 gatgaagggc atataaataa tgtggctgtt catagtgact atagagggaa aaaaataggg
    46681 gacaagttga taaaaggcat agttgattta tgtaaagata ataatattgc atctatgaca
    46741 ttagaagtta gagcatcaaa taaaatagca caaaatttat atagaaaata tggatttaaa
    46801 atgggtggaa taagaaaaga atactacagt gataataaag aagatgcaat tataatgtgg
    46861 aaccaattaa aagaggtgta gagtttatga gtgatataat aacattagct atagagagta
    46921 gttgtgacga aacagctgca tcagttttaa aaaatggtag agaagtactt tcaaacataa
    46981 tctctactca aatagagaca cataaaaaat ttggtggtgt agttccagaa gtggcttcaa
    47041 gaaaacatgt ggaaaatatt gatatagttg ttcaagaagc tttagacaaa gcaaatatag
    47101 gttttaatga tatagaccat atcgcagtta catatggacc tggactagta ggtgctttat
    47161 tggttggtct atcttatgct aaagcacttg catatacttt gaatattcca cttgtaggag
    47221 taaatcatat agaagggcat ctaagtgcaa actatataga gcataaggat ttgaaacctc
    47281 cttttataac attaatagta tctggaggtc atactcactt ggttgaagta aaagattatg
    47341 gcaagtatga aattttagga aaaacaagag atgatgcatc tggagaagca ttcgataaaa
    47401 tttcaagagc aatgaattta ggttatccag gaggacctat tattgataat ctagccaaga
    47461 agggaaataa acatgctata gagtttccaa gagcctattt agaagaagat agttatgatt
    47521 ttagttttag tggattaaaa tcttctgtat tgaattatct aaatgggaaa agaatgaaga
    47581 atgaagaaat agtagttgaa gatgtagcag catcttttca agaggctgtg gtagaggttt
    47641 tatctactaa ggcactaaaa gcagtaaaag aaaaaggata caatatcata actctttctg
    47701 gtggagttgc ttctaattcg gggcttagag ctaaaataac agagcttgct aaagacagtg
    47761 gtattactgt taagtatcct cctctaattt tatgcacaga taatgcagct atgatagggt
    47821 gtgcaggata ttataatttt ataaacggga aaacgcatga tatgagttta aatgcagttc
    47881 caaatttaaa gataaatcag tagagttaga taaatttgta aatataaaag tattgtttca
    47941 aaaaagtaag cagaagtgaa attaaatata ataaaaatca atatagtata tattaaaact
    48001 tgaagtaaaa ctatttataa tctttatatt ccaatgaatt gcaacacatt ttaggatata
    48061 caggttgtct ttggcttaga tttgcttcaa gtttaatttt ttctatagaa agattatttt
    48121 aaaaagtggg taatataccc ttttttttca ttcttaaaaa gttttatact aattatagaa
    48181 agattaagga ggggaagaaa tgagtcaaag taaagaagac aaaataagaa gtattttgga
    48241 agcaaaaaat atcaaatcaa attttcaaaa taaagaaaat ttaagtgaat ttaatgaaaa
    48301 aaaagcaagt aaaagagcag aagacttatt agatgtatat tataatacat tatctactgc
    48361 agatatggaa tttccatatt ggtataatag agaatataga aaatcagatg gtgatatacc
    48421 agtagttaga agagctaaag ctcttaaatc tgctttttca catatgacac caaatataat
    48481 acctggtgag aaaatagtaa tgcaaaagac acgccattat agaggttctt ttccaatgcc
    48541 atgggtaagt gaaagtttct ttgttgctca aggagaacaa atgagagaag aggcaaagaa
    48601 attagccagt aacacagctg atgaacttac aaaatttggg tctggcggag gaaatgttac
    48661 tgaaagtttt ggaaatgtcg tttcaatagc tggtaaattc ggaatgagaa aagaagaagt
    48721 acctgtactt gtaaaaatgg caaaagaatg ggttggaaag tctgttgaag atttaggttt
    48781 tcactatgaa aaaatgatgc cagattatga tttaaaagaa aacctaatga gtacacttat
    48841 atgtatgttt gattcaggat atacacttcc tcaaggtaga gaagttataa attattttta
    48901 tcctttaaat tatggattag atggaattat agaaatggca aaagaatgta aaaaggcagt
    48961 tgcaggaaat gcatctggag atgggcttat tggtatggac cgtctatatt tttatgaggc
    49021 tgttattcaa gttattgaag gattacaaac ttggatttta aattatgcaa aacatgcaaa
    49081 atatttagaa agtatagaga cagatttaga agctaaaaaa gaatactcag atttagtgga
    49141 gatattagaa catattgcac ataaacaacc tcgtacattt agggaagctc ttcagttgac
    49201 ttatacaatt catatagcat cagtaaatga ggatgctata tctggtatgt ctataggccg
    49261 ttttggtcaa attttatatc cttggtatga acaagatata gaaaaaggat taattacaaa
    49321 agaagaggtt atcgaattat tagagcttta tagaataaaa atcacttgta ttgactgttt
    49381 tgcttcagcg ggcgtaaatg gaggagtact atcaggaaat acatttaata ctttatctat
    49441 aggtggatta aaagaagatg gttctacagg agctaatgaa ctagaggagt tattattaga
    49501 agcaagtatg agatgtagaa ctcctcaacc tagtttaact atgttatatg atgaaaaact
    49561 tccagaagat ttcttaatga aagctgctga atgtacaaag cttggttctg gttatccagc
    49621 ctgggtaaac aactcaaatg gaacaacatt tatgatgaaa caatttgctg atgaaggtat
    49681 gactgttgaa gaagcgagag catttgcatt aggaggatgt ttggaaacgt ctccagggtg
    49741 ctggaaacag ttaactttaa acgggaagac atactctatt gcaggtggag caggtcaatc
    49801 tgctggctct ggagttcact ttatagctaa tcccaaaatt ttagaacttg ttcttatgaa
    49861 tggtaaagac catcgtatga atatacaagt atttgagcct cataataagc cattagatac
    49921 ttatgaagaa gtcatagaag tatttaaaga ttattataaa caagcaataa atgttttaga
    49981 aagagcaaat aacattgagt tagatatatg gagaaaattt gatacttcta taataaattc
    50041 actattaaag ccagactgtt tagacaaagg tcaacatata ggaaatatgg gatatcgtta
    50101 taatgcaaca ttaaacgtag aaacttgtgg tactgttact atggtcaatt catttgcagc
    50161 acttaagaaa cttgtatatg atgacaaagc atttacaata gaggaaatga aggatgccat
    50221 attaaataat tttggattta aagatgcatt agaagtagga aattattcta tggcagacca
    50281 agtaaaagta gataagactg gtaaatatga tgctatttat aaggcctgtc ttgatgcacc
    50341 taaatatgga aataatgatt tgtatgcaga taatattctt aaaaactatg aggtatggtt
    50401 atcaaaagta tgtgaagaag cacaatcttt atatgctaag aagatgtacc cttgccaaat
    50461 atctgtttct acacatggac cacagggagc tgctaccttg gctactgcag atggtagact
    50521 aagtggaaca acatattcag atggttcagt ctctgcatat gcaggaacag ataaaaatgg
    50581 ggtatatgca ttatttgaat ctgcaactat ttgggaccaa gcagtagttc aaaattctca
    50641 gatgaattta aaacttcatc caacaactat aaaagggcaa caaggaacta aaaaattatt
    50701 agatttaaca agaagttatt taagaaaagg tgggttccat attcaatata atgttgtaga
    50761 ttcagaaaca ttaaaagatg cacaaaaaaa tcctgacaat tatcgtcaat taatggtacg
    50821 tgttgctggg tttactcaat attggtgtga attaggtaaa ccaatacaag atgaagtaat
    50881 tgctagaaca gagtatgaag gggtgtaaaa tatgagaaag catagtgatt gtatgaattt
    50941 ttgtgcagta gatgcaacca aaggaatttg tagattatca aaacaaatga ttaatttaga
    51001 tgatgcagca tgtccagaga taaaagtaat gccaaaatgt aaaaattgta aaaattttgt
    51061 tgaagctaat gatgaaggta taggcaaatg tgttggccta gagaaagaag actgggtata
    51121 ttcaacattg aatgcaatta cttgtgaagg acatgtgttt aatgagtagt caaaagcaat
    51181 tagaaggcat gattttcgat gtacaaagct tttcagttca tgatggtcca ggttgtagaa
    51241 caactgtatt tttaaatgga tgtccactga gttgtaaatg gtgtgcaaat ccagaaagtt
    51301 ggactgtaag accacatatg atgtttagtg aattatcttg tcaatatgaa aatggatgta
    51361 ctgtatgtca tggtaagtgt aaaaatggtg cattgagctt taatcttgat aataagccag
    51421 ttatagattg gaacatctgt aaggactgtg aaagttttga atgcgtcaac tcatgttatt
    51481 ataatgcgtt taaattatgt gcaaaacctt acactgtaga tgaacttgtg caggtaatta
    51541 aacgtgattc taacaattgg agaagtaatg gaggagtaac atttagtgga ggtgagccac
    51601 tacttcagca tgaattttta catgaagtat tattaaagtg tcatgaggta aatatacaca
    51661 ctgccattga aacgagtgca tgtgtatcaa atgaagtttt taataaaata tttaacgata
    51721 ttgattttgc atttattgat ataaagcata tggatagaga aaaacacaaa gaacaaacag
    51781 gtgtgtataa tgatttaata ttagaaaata tatcaaacct tgcaaattct gattggaatg
    51841 gaagattagt acttagagta ccagttatct ctgggtttaa tgatagtgat gaaaatataa
    51901 gtgatattat atcttttatg cacaaaaata atttggtaga aattaatcta ttaccatttc
    51961 acagattagg agaatcaaaa tggattcaat taggcaagga atatgagtat tctgataagg
    52021 gtgatgttga tgaaggtcat cttggagaat tacaagatat atttttggat aatggtatag
    52081 cttgttatgt tggtcatgag acagctttct aaaattaaat acaagtttta attaaaaaag
    52141 gatgttacac taaaagctag agttacatcc ttttttatgt ggtttttatg tagaaataat
    52201 taagtaaagt tttatatatt ttatatattg tttatattgc tttatgtcca taaatattgc
    52261 tttaaatata ctttatatat tttttatagt ttaaattaca gttagagaat atattacgtt
    52321 tactttattg aagcagaagt tttgtggtaa aatactacta tgaaaaaatt taatagaata
    52381 tattttagaa acaactaaaa ataatagtta ggaggaagac atctatatga acaaatcatg
    52441 gagcaacttg attattaaga ataaagacaa aaaagtacgt tcagggtgga ttattatagc
    52501 tgttatggct accttttaca tatttcagta ttatttaagc atgatacttg tggaaataat
    52561 aagaaaaatc ctggttgcta caggggacat taatttaaaa acaaactatt tttcagaata
    52621 tgctaattgg ttaaatgatg ttgggttaca gattgtattt caaattctaa cagattcact
    52681 tatgattatt attcctataa ttgtatggag atttattatg aaaaatccta ttagtgaaat
    52741 gggattacat tcttatagaa ttaagaaaaa agaaggatat gtaggaatgt tattaggaat
    52801 atttaattgt acagtaatct ttattataac aataacaatt ggtggtggtc atgttacttc
    52861 atgggtacca aaaatttcac ctttaacagt ttcttgaata cttgtcttta ttttagttgc
    52921 ttttgcagaa gaaattttaa atcgtggttt ttttatggca gttttacgaa gatgtaaaaa
    52981 tatttatttt ataatgattg ttccatctgt tatttttggg ttgattcata tatggaatcc
    53041 tgatgttact tttttgtctg taattaatat tataattatt gggattcttt tttcatatat
    53101 gtttataaag tcgtcgaata tatggatgtg tataggttat cattttacat ggaatgtatt
    53161 tcaggggatt atatatggta tgcctgtaag tggacttcag gttccaggga ttataactac
    53221 acaaatcact catggtaatc tattaaatgg tggtatgttt ggtattgaag gtggaatttt
    53281 gactactttt gttaatctac ttagttttat atttgtatgg tattactata gagattctaa
    53341 gtatgatttt gttagtgata aagtaaatgt gaccaatatc aagaattagt tgattataat
    53401 aaattttaat aatatcttct aagcttaaag tattctgtag gattgttgga aatttacaaa
    53461 aatataaaaa taacttggat attctattta ctccaagtta tttttatatt cttttgtaaa
    53521 tagaaatgga acataaaaaa ttaaaacaac catagatact attagtatat catggtaagt
    53581 gatagttgat tctttagaat ttgtgataag aaaagcacta ttatttaaaa tatgaattat
    53641 agcacaaaac cagatgttct tagtttttat ataaagatat cctaaaaata ttgaaattcc
    53701 aactatatgt atcgaacgta atattaatcc taatattggt gtttcaggtg tatataatgt
    53761 aaatattagt ggtaagtgcc acaaactcca acaaatacct aatattataa ctcctagttt
    53821 tttaccaaat ttattaaaaa aaatattctg taaaaaacct ctccaggcat attcttcact
    53881 aaaaaaaata taaatagtag ttaatgatgt tattggagta aatataaatt ttatgatacc
    53941 actataatta ggttgagacc cttgtagtat taatataaat gatgttggaa caattacaga
    54001 aatcataaag taaataatta acaaagaacc tagtttaata ttttttatag gat
//
LOCUS       DAEPID010000020        53087 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.020, whole genome shotgun sequence.
ACCESSION   DAEPID010000020 DAEPID010000000
VERSION     DAEPID010000020.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 53087)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 53087)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..53087
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.020"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            complement(<1..884)
                     /locus_tag="KR257_001327"
     CDS             complement(<1..884)
                     /locus_tag="KR257_001327"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009243519.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional lysozyme/C40 family peptidase"
                     /protein_id="HBH0030040.1"
                     /translation="MKLKHIAIIGSLFPILFSLVLFFGVLISADSDDENSNFSSGITG
                     MNLSAEVLKHQTMVEKYARENGISEYVNVLLAIIQVESGGTAEDVMQSSESLGLPPSS
                     LDTESSIKQGCKYFASLLSSCKNQDIDDLNVAIQSYNYGGGYVGYVAGNGKKHTFNLA
                     ESFAREKSGGKKVTYTNPIAVAKNGGWRYGYGNMFYVELVNQYLTVPQVSGELAQKVM
                     NEALKYQGWKYVFGGSSPTTSFDCSGLTQWCYGKAGISLPRTAQAQYDATQHLPLSQA
                     KAGDLVFFHSTYNAGSYVT"
     gene            complement(881..3085)
                     /locus_tag="KR257_001328"
     CDS             complement(881..3085)
                     /locus_tag="KR257_001328"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002323347.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MFS transporter"
                     /protein_id="HBH0030041.1"
                     /translation="MKERIQSAFTKRKILHFLKMALFVVALSLILLSLLGTVAHATGL
                     VDDTINAENLYSKYPLSNYQLDFFVDNSWSWLPWNWLDGIGKSVQYGLYCITNFVWTI
                     SLYLSNATGYVVQEAYKLDFINDMADSIGKSIQTLAGVTENGFSSTGFYVGFLLLIIL
                     VVGMYVAYTGLIKRETSKALHAVINFVVVFVLSASFIAYAPDYIKKINEFSSDISTAS
                     LDLGTKIMLPNSDSEGKDSVDLIRDSLFSIQVQQPWLLLQFGNSNAEEIGTDRVEALV
                     SASPEDEDGKTREEVVKTEIEDNDNNNLTIPQVVNRLGMVFFLLFFNLGITIFVFLLT
                     GMMLFSQILFIIFAMFLPISFLLSMIPSYESMAKQAIVRVFNTIMTRAGITLIVTVAF
                     SISSMFYNISTDYPFFMVAFLQIVCFAGIYMKLGDLMSMFSLNAGDSQSMGRRIFRRP
                     YLFMRHRARRMEHRIARAVSAGGISGGVAGAVAGSAVAGKRAERKNTASKENRGNTTS
                     SMGQRAGSKVGAVLDTKNKVKDKANAVKENIKDMPTQTAYAVYSAKEKAKSSVSDFKR
                     GMVQEQQSRQTGRLEKQEQHKKSIAVKRMELQKAQEARQAQRKADGSATTGATRPHER
                     PATASTVSKTGAEKMQEVKRPATTPTTKASEPVKTSGVKERPLSSSTPDGKATQSTYR
                     QNVEKVTVSKETRQNYTKDRRTKVQQTQTVQKNQQTTEKIRNLVTKKGQKKK"
     gene            complement(3085..5535)
                     /locus_tag="KR257_001329"
     CDS             complement(3085..5535)
                     /locus_tag="KR257_001329"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898619.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding protein"
                     /protein_id="HBH0030042.1"
                     /translation="MFPIKYIDNNLVWNKDNEVFAYYEMIPYNYSFLSAEQKFIVHDS
                     FRQLIAQSREGKIHALQIATESSIRSMQEQSKKLVTGKLREVAVQKIDEQTEALVSMI
                     GDNQVDYRFFLGFKLMVTEEQLNLKNIKKSAWLTFKEFLHEVNHTLMNDFVSMPNDEI
                     NRYMKMEKLLENKISRRFKVRRLEIHDFGYLMEHLYGRDGIAYEDYEYQLPKKKLKKE
                     TLIKYYDLIRPTRCVIEESQRYLRLEHEDKESYVSYFTVNVIVGELDFPSSEIFYFQQ
                     QQFTFPVDTSMNVEIVENRKALTTVRNKKKELKDLDNHAYQAGSETSSNVVDALDSVD
                     ELETDLDQSKESMYKLSYVIRVSAPDLDELKRRCDEVKDFYDDLNVKLVRPAGDMLGL
                     HSEFLPASKRYINDYVQYVKSDFLAGLGFGATQQLGENTGIYMGYSVDTGRNVYLQPS
                     LASQGVKGTVTNALASAFVGSLGGGKSFCNNLLVYYAVLFGGQALLLDPKSERGNWKE
                     TLPEIAHEINIVNLTSDKDNAGLLDPFVIMKNVKDAESLAIDILTFLTGISSRDGEKF
                     PVLRKAVRSVTQSENRGLLHVIEELRKEDTAISRNIADHIDSFTDYDFAHLLFSDGTV
                     ENAISLDNQLNIIQVADLVLPDKDTTFEEYTTIELLSVSMLIVISTFALDFIHSDRSI
                     FKIVDLDEAWAFLNVAQGETLSNKLVRAGRAMQAGVYFVTQSAYDVSKESLKNNIGLK
                     FAFRSTDINEIKQTLEFFGIDKDDENNQKRLRDLENGQCLLQDLYGRVGVVQIHPVFE
                     ELLHAFDTRPPVQRNEVE"
     gene            complement(5513..5911)
                     /locus_tag="KR257_001330"
     CDS             complement(5513..5911)
                     /locus_tag="KR257_001330"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009274602.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="conjugal transfer protein"
                     /protein_id="HBH0030043.1"
                     /translation="MKKIKSYTGIWNVEKVLYAINDFNLPFPVTFTQITWFVITEFII
                     ILFGDMPPLSMIEGAFLKYFGIPVALTWFMSQKTFDGKKPYSFLKSQITYALRPKITY
                     AGKAVKLHKQILNETITAVRSVNYVPDKIY"
     gene            complement(6029..6532)
                     /locus_tag="KR257_001331"
     CDS             complement(6029..6532)
                     /locus_tag="KR257_001331"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004843360.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="antirestriction protein ArdA"
                     /protein_id="HBH0030044.1"
                     /translation="MIDDMAVYIANLGRYNEGYLVGAWFTFPIDEEDVKEKIGLNEQY
                     EEYAVHDTDNFPIDIGEYVSIEELNEMYEMIEELPDYIVECLDEFISHYGTLEEVVEH
                     KDDIYFYPDCETMTDVAYYYIDELNALGDIPANLQNYIDYEAYGRDLDMGGRFIETSR
                     GICEIPY"
     gene            complement(6550..7053)
                     /locus_tag="KR257_001332"
     CDS             complement(6550..7053)
                     /locus_tag="KR257_001332"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004843359.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="antirestriction protein ArdA"
                     /protein_id="HBH0030045.1"
                     /translation="MQETRVLVETGRTNGEETTSYWFDLPIDVAEFEEKLGVGAESQD
                     YRIIEKVLPYADEVHEHTSVYQLNELDFMYRQLSADMQEEYVELLTVFENLEALYICR
                     NVITVYHDCKSMIDVARQKLMNDPTFKHLSEDCQAYYFDFEAYASHLLENKRYLVTEN
                     SIFELPE"
     gene            complement(6972..7268)
                     /locus_tag="KR257_001333"
     CDS             complement(6972..7268)
                     /locus_tag="KR257_001333"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005339688.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="conjugal transfer protein"
                     /protein_id="HBH0030046.1"
                     /translation="MNDIFKDMQAKVGCEYISDLPSYKRKVWHEMKRLNPADYEEKQL
                     KDFSKYVFGMSYQTLKDVMKQQKGREEQCRKQGYWWKREEQMAKKQHHTGLTYR"
     gene            complement(7367..8161)
                     /locus_tag="KR257_001334"
     CDS             complement(7367..8161)
                     /locus_tag="KR257_001334"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0030047.1"
                     /translation="MGTINYFLKGIKVLMISDEMRVDILHAVFINKNFIKDEENCNYE
                     KYLLELVNKSIYFREKSNFAEYVPPKSENHGECDCNSPNYQMDFKLLESTTRLHASKE
                     LTGQIQKFCDGVIGKCPPRRPNTQMTVTRLFASLRDYDCESLHSCLTEKYEYGTIEFD
                     IQTYVKLLTFKKNLFFFFPYKFSFNTCYNFKYALDSIRIALEKDFRESNLFREKYYAE
                     YDTFLAYIYEDNLIISKFEQDGKLQMIDCIYLFKSQTYSKLYEYTW"
     gene            complement(8200..8421)
                     /locus_tag="KR257_001335"
     CDS             complement(8200..8421)
                     /locus_tag="KR257_001335"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002570387.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0030048.1"
                     /translation="MNFGQNLYQWFLSNAQSLVLMAIVVIGIYLGFKREFSKLIGFLV
                     VALIAVGLVFNAGGVKDVLLELFNKIIGA"
     gene            complement(8422..8556)
                     /locus_tag="KR257_001336"
     CDS             complement(8422..8556)
                     /locus_tag="KR257_001336"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017143882.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3789 domain-containing protein"
                     /protein_id="HBH0030049.1"
                     /translation="MWELVKDFLLVSMGMGIGVVLMCILSISKEADYEMKQLEESEDN
                     "
     gene            complement(8569..9765)
                     /locus_tag="KR257_001337"
     CDS             complement(8569..9765)
                     /locus_tag="KR257_001337"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003062030.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="XRE family transcriptional regulator"
                     /protein_id="HBH0030050.1"
                     /translation="MVLNEEQWIKELREKRIAYGISQGRLAVASGITREYLNKIESGK
                     MKPSKELLETLHKELARFNPEAPLTMLFDYVKIRFPTLDIQHIIKDILKLNINYMLHE
                     DYGHYSYTEHYSLGDIFIYTSADEEKGVLLELKGRGCRQFESYLLAQQRSWYDFLMDA
                     LIDGGIMKRIDLAINDHTGILDIPELAEKCRKREYIGKSRSYKYYQSGELIKHREDDR
                     EYMGSTLYLGSLKSDVYFCIYEKDYEQYVKLGTPLEEADIINRFEIRLRNERAYYAVR
                     DLLTYYDAEQTAFSIINQYVRFIDEEPDKRKNDWKLNDRWAWFIGDNRQSLKLTTKPE
                     PYTLDRTLRWVQRQVAPTLKMLKKIDKGNGTDYMETIEKQAILSEKHEMIIKQQTTPA
                     KDLVES"
     gene            complement(9950..11344)
                     /locus_tag="KR257_001338"
     CDS             complement(9950..11344)
                     /locus_tag="KR257_001338"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008787614.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding protein"
                     /protein_id="HBH0030051.1"
                     /translation="MRMILNKGHRIRASDKNLVYRFSMGTLLFVFVAVILLLNTKQLM
                     RTDWEHFSLLDNGFTLSLYNFITILIATGVCALVAFLYYRFCYDSFKKLLHRQKLARM
                     ILENKWYEADTVQDSVFFTDLQSRSREKIVWFPKIYYQMEKGLLHIRCEITLGKYQDQ
                     LLRLEDKLESGLYCELTDKTLHDGYIEYTLLYDMIANRITIDEVRAENGCLRLMKNLV
                     WEYDALPHALIAGGTGGGKTYFLLTLIEALLHTNAVLYILDPKNADLADLGTVMGNVY
                     HTKEEMIDCVNAFYEGMVQRSEQMKRHPNYKTGENYAYLGLPPCFLIFDEYVAFFEML
                     GTKESVGLLSQLKKIVMLGRQAGYFLIVACQRPDAKYFSDGIRDNFNLRVGLGRISEL
                     GYGMLFGSDVKKQFFQKRIKGRGYCDVGTSVISEFYTPLVPKGHDFLQTIGFLAQARQ
                     DGTATCEAKGDGSD"
     gene            complement(11438..11875)
                     /locus_tag="KR257_001339"
     CDS             complement(11438..11875)
                     /locus_tag="KR257_001339"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004056026.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0030052.1"
                     /translation="MCEECYSDENRITPLLNPLDCLENHTQYICGTCGRCICIEHDPN
                     RGLQRWNFPFKSLEIAKLYLRTADYTTKSSCGIYEIENSKGRVSYKIFAGNEDLHLFL
                     KKNKDKKCKQMTPVFNVGEYKEYPHTEVRKLTSDEIKQYMSER"
     gene            complement(11977..12360)
                     /locus_tag="KR257_001340"
     CDS             complement(11977..12360)
                     /locus_tag="KR257_001340"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009588269.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YdcP family protein"
                     /protein_id="HBH0030053.1"
                     /translation="MRLSNGFVIDKEKTFGELKFTAVRDVFLQNEDGTPSTQLKKRIY
                     DLKCSLHGGIIPVSVPPEVPLREFPYNAVVELVNPVADTVSRKTYTGADVDWYVKAED
                     IVLKNKGNQNTGTSQNHTPQGQPKK"
     gene            complement(12376..12702)
                     /locus_tag="KR257_001341"
     CDS             complement(12376..12702)
                     /locus_tag="KR257_001341"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003417601.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YdcP family protein"
                     /protein_id="HBH0030054.1"
                     /translation="MEMKYVVPDMAQSFGTLEFAGESEPIFERDKNNRKVIARRSYNL
                     YSDVQKGENVVVEIPVQAGEKHFKYEQKVKLVNPKLYGRGYAIGDVGHTDYVLVADDI
                     VAVEEK"
     gene            complement(12828..15872)
                     /locus_tag="KR257_001342"
     CDS             complement(12828..15872)
                     /locus_tag="KR257_001342"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861958.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SrtB-anchored collagen-binding adhesin"
                     /protein_id="HBH0030055.1"
                     /translation="MKKILKRLCTGVLAFATVVTALPSTAVHAESKQYWTESEERVGI
                     VEKVMNDGSIGSTFNEGHLTVEGEDAYCIDINTDFKNGYKTRADASTRMSADQISDVA
                     LSLEYVKQYGEAHKELNYKQVYLLEQCVVWQRLSVHLGWQCDNVRASYDEIPKATQDE
                     VFAGAKAFVKENKGRYECGGYIYSGEGQELGQFWAKLNVGNAKLQKTSSNTSITDGNG
                     NYSIAGATYGVFSDKDCTKQLATLTTDKNGNTDVVEVKAGTVYIRELSAPAGYKVDTT
                     VYSLKVEAGKTATLNVSDTPKVTDTLIELFKIDMETQKDNPQGNASLEGAEFTWKYYA
                     GFYNKDNLPAEATRTWVTKTIAETDSDGTTHYITKLADAYKVSGDSFYMQDGKAILPL
                     GTLSVEETKAPNGYLLDGAYMQAGDKSEQIKGLYLTQITEDGDLAVLTGSNQFSVSDK
                     VIRGGVKIQKRDLETSDTKPQGSATLKDTAFDVISLNDNSVLVEGKLYKKNEVVKTIR
                     TDIEGVASTSADLLPYGKFRIVESEAPDGYLTDGAKPIDFAITENGKIVDLTDEAHSI
                     YNQIKRGDIEGVKIGAGTHKRLADVPFRITSKTTGESHVVVTDDNGQFSTSAEWTSHK
                     HNTNAGKTSEDGVWFGTSEADDSKGALPYDTYIIEEMRCDSNKGFELIPPFEIVVSRN
                     NLVIDLGTLTDEYEKEISIHTTATSKDSEKTILAGKEVTIVDTVKLDGLTKGTKYQLK
                     GWQMLKEENAELIIDGKRVENDYTFIADDEEMKVEISYTFNASELGGKNLVTFEELYD
                     LSNPDEPVKVAEHKDIEDDGQTVLITERIIKIHTTATDKDGNKEIEAGKDVTIIDTVT
                     LEGLEVGTQYKLVGWQMLKEENAELLINGKRVESDYTFTADSETMKAEVAFTFDATSL
                     DGKQLVTFEELYDLSNPDEPKKVTEHKDIEDEGQTITFNEKPEVPEKLETPQTPEKPN
                     RPSDSPKTGDSTNVMAFLVMLLTSAGGLAGTYLYKRRTMKKS"
     gene            complement(16115..17479)
                     /gene="rlmD"
                     /locus_tag="KR257_001343"
     CDS             complement(16115..17479)
                     /gene="rlmD"
                     /locus_tag="KR257_001343"
                     /EC_number="2.1.1.190"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898634.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="23S rRNA (uracil(1939)-C(5))-methyltransferase
                     RlmD"
                     /protein_id="HBH0030056.1"
                     /translation="MLSKNEMYIVDIVDIGQGGVGVGKYNGITVFVEGGLIHDKVKVR
                     INKVKKNYAVGDIVEIIEKSPFRVKRVCSDNLRDCGGCQIQDLDYNKQLEMKTNEVKQ
                     VLSRIGKLEDVEVHDTIGMDNPYRYRNKAQFPIQKNNGIPIIGFYKKKTHDVISTEKC
                     VIQHEINDKIVKIIKTYIRAYKVSIYDEKTHTGLIRHLVTKIGFTTKEVMVVLVANGN
                     KLPYLKELASVLKENIPGFKTLVVNVNQKDTNAILGRENIVIYGDGKINDYIGDLVFE
                     ISPLSFFQVNPVQTKVLYDKALEYANLNDTDTVFDIYCGIGTISLFLAQKAKKVYGIE
                     IIDDAIKDAKINAKLNNIHNAEFYVGKAEEIVPKMYREGKTANVVVVDPPRKGCDEKV
                     LETIVSMNPERIVYVSCNPSTLARDLDYLNVHGFKCVEAQPVDMFPHSTHIETCVLLQ
                     RRTM"
     gene            complement(17654..19414)
                     /gene="pyk"
                     /locus_tag="KR257_001344"
     CDS             complement(17654..19414)
                     /gene="pyk"
                     /locus_tag="KR257_001344"
                     /EC_number="2.7.1.40"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436250.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pyruvate kinase"
                     /protein_id="HBH0030057.1"
                     /translation="MLNNVKKTKIVCTLGPASQSEEVLTQLMQNGLNVCRFNFSHGSH
                     EEHKERIDMAKKVREKLNKPVAILLDTKGPEIRTGNFEDPEVFLEEGQKFTITMKDIM
                     GTKEMCTVSYKGLAEDVKSGDSILIDDGLVGLRVKEINGEDIVCVVENSGIVKNHKGV
                     NVPGVKINLPAITPKDISDIEFGISQGIDYIAASFVRKASDVLAIREVLENNNATDIQ
                     IISKIENQEGVENLDEILKVSDGIMVARGDLGVEIPTEEMPIVQKMMIKKCNELAKPV
                     VTATQMLDSMIRNPRPTRAEVTDVANAIYDGTDAIMLSGETAAGKYPVEAVKMMATIA
                     KRTEETLDYDRLLKENGTNNVTVTDAISHATCTTAVDLNASAIITSTSSGYTARMVSK
                     FRPKSPIIATTNNEKTMNKLALTWGVYPVKSSVAGNTDEVIEKAIEAARQADYIDNGE
                     LVVITAGVPVGVSGTTNLIKVHVISEEIVQGIGVGTQTVEGKVRIIKNGNACVDFNEG
                     DILVSTATDAEMNNYIEKAGAVVTENGGMTSHTAIVGINLDIPVIVSAADITNLVKDG
                     EVVTVDASRGVVYRGSTRVL"
     gene            complement(19466..20425)
                     /gene="pfkA"
                     /locus_tag="KR257_001345"
     CDS             complement(19466..20425)
                     /gene="pfkA"
                     /locus_tag="KR257_001345"
                     /EC_number="2.7.1.11"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416974.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="6-phosphofructokinase"
                     /protein_id="HBH0030058.1"
                     /translation="MKTIGLLTSGGDAPGMNAAIRAVVRSAIYYGCKVYGINRGYKGL
                     LEEDLTEMNLSSVGDIIHRGGTILKSSRCEEFKTEEGRLKAVKILKKYKIDCLVVIGG
                     DGSFAGAQKLSDLGFPAIGIPGTIDNDLAYTDYTIGFDTAMNTIIDAIGKIRDTSSSH
                     ERVNIVEVMGRHCGDLALYAGLAGGAETIIVPEVEITVDEVALRLKTTQKRGKRHSII
                     VLAEGVGSASDLEKELKKESGADLRVTVLGHVQRGGSPTVSDRILASRLGVRAVELLL
                     DGKSARVVGIKENKIIDLEISEALAQKKVFDKEAYEMAKILSI"
     gene            complement(20634..24203)
                     /locus_tag="KR257_001346"
     CDS             complement(20634..24203)
                     /locus_tag="KR257_001346"
                     /EC_number="2.7.7.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728492.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA polymerase III subunit alpha"
                     /protein_id="HBH0030059.1"
                     /translation="MNKDFAHLHVHTEYSLLDGFSRVKKLIKRAKELNMSSIAITDHG
                     CMFGVIDFYKTAIKEGIKPIIGCEVYTAARGLRDKDPNYDKYQGHLVLLAKNMEGYKN
                     LIKIVSTSYVEGFYYKPRVDMEELKKHNKGIIALSACLAGDVARALMNRNYEKAKQFA
                     LDYRDIFGEENFFLEIQDHNLPEQKEVNSGLVKLSKETGIPLVATNDVHYVNKEDSKI
                     HDVLMCIQMGKTLNDPNRMRFGSDEFYLKSREEMEELFPYALEAIDNTVKIADMCNVE
                     FDFNTIHLPKYDVPEGYTPETYLRELCFNGLKERYDNPSNEILERLNYELDVIEKMGY
                     VEYFLIVWDFINFSKENNIIVGPGRGSAAGSIVAYTLKITDIDPIKYSLLFERFLNPE
                     RISMPDIDIDFCYERREEVIDYVKRKYGDDHVAQIITFGTMGAKAAIRDVGRVLDIGY
                     NKVDKVAKEIPFALGMTIDKALDTNPNLKELYDQDPETKEIINISKQIEGMLRHASTH
                     AAGVVISKNPVDEYVPLYKHQDAITTQFTMTTLEELGLLKMDFLGLRTLTVIRDTLDL
                     IEKNRVIKNYTEKIDFSKMDYDDPKVYEMLSSGNTLGVFQLESAGMRSFMKQLKPDNF
                     EDIVAGISLFRPGPMDSIPAYIKNKSNPKDVTYLHEKLKPIMEVTYGCLVYQEQVMQV
                     VRDLGGYSYGRSDLVRRAMSKKKMDVMEEERQYFIHGKFDEDGNIEIAGCIRNGVEEE
                     IANKIFDDMIDFARYAFNKSHAAAYGVLAYETAYLKTYYPVEFMAALITSVMGNTDKV
                     VEYIRECKALEIDVLPPDINKSFSKFSVEGDNIRFGLAAVKNVGVNIINNIIAERESN
                     GLFVDLVDLVKRLDQKDTNKRVIESLIKCGAFDNISENRASLMAGYESLLESVSMDRK
                     KNVQGQISLFDAFGDSEEDSDFQQIYSLPKRQEYEERERLNLEKEVLGMYVSGHPLSQ
                     FEKELQEKTSMDNGKLNSLKEEEESYLQMNETDVIMGGMIVTKTIKTTKRNEIMAFIE
                     LEDLYGAIEIIVFPQLLQKYNVILNEDNIIYVKGTLSIKEGENAKLIAREIKDINDDT
                     DFADRNYNSGRTRNVENIKPESGKKLYLKIDSMSDTDTTNNIVEIAKQYPGNDSIYLY
                     PMDENINGKRKAYKMTGALTCICDEFINNLEELLPKDNIKVKA"
     gene            complement(24360..25307)
                     /gene="whiA"
                     /locus_tag="KR257_001347"
     CDS             complement(24360..25307)
                     /gene="whiA"
                     /locus_tag="KR257_001347"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436252.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA-binding protein WhiA"
                     /protein_id="HBH0030060.1"
                     /translation="MSFSTETKNELARVISGNECCNIAELSALVKSGGSIQIVGYKKL
                     NLKITTELNSIARKVFKLLKKNFNINTTISVNKNQMLKRNNSYVLMVTSEMGSEMLLK
                     KLGILEDKEGFFTINKISENLIKHEGCKRAFIRGAFLGGGSISDPEKNYHMEFVTNNE
                     EFADSLKELINSLGFNSKIVARKNNHVVYIKESEQISDLLSIIGGHHALLSLQNTKIV
                     KEMRNNVNRIVNCETANLSKTVNAAVRQVENIKLIQETIGISSLPENLQEIAKIRIEY
                     EDMTLKELGEMLEPPIGKSGVNHRLRKIEEIATDLKKKS"
     gene            complement(25324..25749)
                     /locus_tag="KR257_001348"
     CDS             complement(25324..25749)
                     /locus_tag="KR257_001348"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416968.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NUDIX hydrolase"
                     /protein_id="HBH0030061.1"
                     /translation="MREEVSAGGVVLFGNTILLLRKFNGDWVLPKGKVEEGENNQEAA
                     LREVSEETGVKADILKYLGEIHYTFKENWDENRAVHKTVFWYLMQAKNMDTIPQKEEG
                     FIDAKFIHLDRVVDLARYDDEKEIIKVALQEIKKRLKKN"
     gene            complement(25818..26924)
                     /locus_tag="KR257_001349"
     CDS             complement(25818..26924)
                     /locus_tag="KR257_001349"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891913.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YvcK family protein"
                     /protein_id="HBH0030062.1"
                     /translation="MAKLLIIVGILGWIALIVSLFIYKKAKNEKVKLFQRSIVENREP
                     NVVVIGGGTGQSVFLRGLKHTTQNITAIVTVADDGGGSGVLREDLGMLPPGDIRNCLL
                     ALANIEPTMNEVMQYRFTEGLLKGQSFGNLFLAAMNGLYGNFEKAVYKLSEIFAITGR
                     VLPVTLEDVNLVAKLENGNIINGESSIPEESKIQKSSIDKIFLNPKDVKPLKDVIASI
                     YDADIIIMGPGSLYTSIIPNLLVEGIVDAIKSSVAPKVYIANIMTQPGETEGYNVLEH
                     VNAIVKHTDENLIDYVIANNEILPEEMLDLYKQDGAEQVLLDKKQKDKLKEMGIKTVE
                     KNLIEIKNNYIRHDAKYISNIVIELALNHNYNKS"
     gene            complement(26936..27793)
                     /gene="rapZ"
                     /locus_tag="KR257_001350"
     CDS             complement(26936..27793)
                     /gene="rapZ"
                     /locus_tag="KR257_001350"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429119.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RNase adapter RapZ"
                     /protein_id="HBH0030063.1"
                     /translation="MKFVIVTGLSGSGKSETMRALEDMGFYCVDNLPPALITKFAELC
                     YQPNSSIDKVALGIDIRGRKFFEALHESLNYLEKENYEYEMVYLDCNDDVLLKRYKMT
                     RRNHPLAKDMQIPEGIKMERKIMEPLKELSTCIIDTTNMKPKDLKEEIKKIYSSGEDN
                     PNLTISVVSFGFKHGILADADLVFDVRFLPNPYYVEELRAKTGDDKEVRDYVMNSKIS
                     EEFYVKLLDMIHFLVPQYIEEGKQHLVIGVGCTGGRHRSVTITNLIAEDLSNKGYRVV
                     KKHRDSMLR"
     gene            complement(27824..28537)
                     /locus_tag="KR257_001351"
     CDS             complement(27824..28537)
                     /locus_tag="KR257_001351"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429113.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PHP domain-containing protein"
                     /protein_id="HBH0030064.1"
                     /translation="MKILADYHTHTLYSHGKGTIEDNVKVAISKGIKTIGISDHSYKH
                     IAYGVKKKDILKMREEVDYLNDKYTDINILLGMECNILDDKGNIDMDDKFIRDFDYIM
                     AGYHFGSTPTSLRSLLNHCNNYIFKTEKAKEYNTKAVINAISNNDIFIITHPGDKGDV
                     YIEEVAKTAKKTNTRLEINSSHSFLNVNQLNKIKGLENKFIIGSDAHCPERVGDFELA
                     MKTISDSNLDISLVENIII"
     gene            complement(28541..29455)
                     /gene="murB"
                     /locus_tag="KR257_001352"
     CDS             complement(28541..29455)
                     /gene="murB"
                     /locus_tag="KR257_001352"
                     /EC_number="1.3.1.98"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009906469.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-N-acetylmuramate dehydrogenase"
                     /protein_id="HBH0030065.1"
                     /translation="MNNQDIYINLLNILSKEDIKVDEPMKKHISFRVGGPADILVRPR
                     TEEQLKNVLKLVKEESIPYLIIGNGSNILIKDGGIRGVVIELADNFNSYEINDTRMTA
                     QSGALLSVLGKALQKQELKGFEFASGIPGTLGGALAMNAGAYGGEMKDIVKSVRLMDM
                     EGNIFELSNEQMEFGYRKSIISKNGYIALSAELELQEGNYDEIKSLMDDLATRRITKQ
                     PLNFASAGSTFKRPTGYFAGKLIEETGLRGLTLRGAQVSEKHCGFVVNQGEASAKDIL
                     DLIYVIKSAVYAKFGVMLEEEVKILGED"
     gene            complement(29728..30498)
                     /locus_tag="KR257_001353"
     CDS             complement(29728..30498)
                     /locus_tag="KR257_001353"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416955.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="formate/nitrite transporter family protein"
                     /protein_id="HBH0030066.1"
                     /translation="MSKGFLTPGETAQATISAGIKKANISTQNAILLGLFGGAFIGFG
                     ALGSMIVSQTFGKIDPGVASFLSAMVFPVGLMLVVVAGAELFTGNTLMAIALMDKKIT
                     LGKMLRNWGLVYFANLVGSILLVALVFYSSTLTGDAATKAIAVAEAKVNSTIASMFLK
                     AILCNILVVLAVWMATASQDIMSKLASCWTVIMLFVLCGFQHSVANMFFIPMGMALGA
                     NITMVQFITNLVFVTLGNIVGGSIVVGGIYYLCYVKNS"
     gene            30816..32297
                     /gene="cls"
                     /locus_tag="KR257_001354"
     CDS             30816..32297
                     /gene="cls"
                     /locus_tag="KR257_001354"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429110.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cardiolipin synthase"
                     /protein_id="HBH0030067.1"
                     /translation="MFDISFFEMSIYEIAVTTIYIINFMVILNLIFREKRNINTTLTW
                     LLILVLIPALGFILYIAFGRNISKNNMFRLKEKDDKIIKSNILDTQVKLQSTSEIDSD
                     IHQHKDMIYALANSNNAHYTNNNDVWIYAESSQFFNSLLEELKKAKKYINIQFYIFKD
                     DKIGTEIIDILIDKAKEGVEVRLLFDAVGGRTLKNSTLSRLKESGVKVGSFFPSFLKI
                     VNFNLNYRNHRKIVVIDGKVGFVGGYNVGDEYLGRNPKFGLWRDTHTKLTGDCVIDLN
                     MRFILDWRYTTKEDLDLEKYFIEEDTNSNHPSENIGIQIVSSGPDISELDEIKYGYLK
                     MIQKARKYIYIQSPYLILDSTFIDTLKIACLSGVDVRVMIPSKPDHPFVYWASYSYAG
                     ELLKFGAKIYTYGQNAFLHAKTIVIDDSICSIGTANMDIRSFELNFEVNAFMYSSKKA
                     LEQRIIFENDILNSKEITLDIYNSRSTYIKIKESISRLLSAVL"
     gene            32615..33112
                     /locus_tag="KR257_001355"
     CDS             32615..33112
                     /locus_tag="KR257_001355"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891918.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NAD(P)H-dependent oxidoreductase subunit E"
                     /protein_id="HBH0030068.1"
                     /translation="MCDFISHNKQLFDELDIFIDSLATKEGALIQVLHEAQGIFGYLP
                     KEVQLHVARKLGVAPAKVYGVVTFYSYFTTEPVGKYKISVCLGTVCFVKGADKILSAF
                     EKQLGIKVGETTSDFKFSLEGLRCLGACGLAPVVTVNGKVYGKVKPDQVSEILDTYRE
                     LELNC"
     gene            33129..35015
                     /locus_tag="KR257_001356"
     CDS             33129..35015
                     /locus_tag="KR257_001356"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416938.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NADH-quinone oxidoreductase subunit NuoF"
                     /protein_id="HBH0030069.1"
                     /translation="MRKVNSFDELKVLADELKPNLSLRKNYSKENVLRRELLVCCDTG
                     CTSSNSLEIVSELENEIKKSGIQDKVSVRLTGCFGFCAQGPIVKVYPDNVFYVKVEPS
                     DAEKIVQSHLIRNTVVEELLYEEESLSKKVEEQEEMSFYKKQLRIALKNCGLIDPDSI
                     EEYIANDGYLALGKCLTSLTPQEVIAEVKTSGLRGRGGAGFPTGSKWEAASKNPAGPT
                     DKKFVVCNADEGDPGAFMDRSVLEGDPHSVLEAMAICGYAIGSDTGYIYIRAEYPKSI
                     ERLKVAIAQAEKYGLLGENILGTGFNFKLELKYGAGAFVCGEGTALMHSIEGRRGEPR
                     MKTYSSSKSGLWKSPTCLNNVETFANIPAIILKGGDWFANLGTEDSSGTKVFALGGKV
                     ENVGLVEVPMGTTLRDIVFEIGGGIPEGKKFKAVQTGGPSGGCIPTEHLDTPIDFGSL
                     SSIGSMMGSGGMLVLDESDCMVDIAKFFLEFTVEESCGKCTPCRIGTTRLLEILTKIT
                     EGNGTLQDLDDLENLAETIQTASLCGLGKAAPNPVLSTLQYFKDEYIAHVVDKKCPAG
                     KCQNLLSYFITDDCKGCTKCSRVCPAGCITGSVKEQHTIDTSKCLKCGACIDNCTFNA
                     IIKK"
     gene            35038..36819
                     /locus_tag="KR257_001357"
     CDS             35038..36819
                     /locus_tag="KR257_001357"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429109.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="iron hydrogenase small subunit"
                     /protein_id="HBH0030070.1"
                     /translation="MSLVNLTINGKHVSAPSGTSILDAAKLINIKIHNLCHLHMNEID
                     KLDTCASCRVCMVETERGLVPACGTVIKEGMKVQTNSAKALNARRTIVELLLSDHPQD
                     CFVCEKNGDCELQTIAADLGVRKIRYQGSKSFAGKDTSTKSLVKDHSKCILCRRCETV
                     CNDIQTVGALSGVNRGFNTLVSTFFNSDMVETECTFCGQCISVCPTGALTEVDNVPKL
                     WDVLNKKEKTIVVQVAPAVRVAIGEEFGLEPGSISTGKMVAALKALGFEHVFDTNFGA
                     DFTIMEEATEFIERIQKGENLPILTSCCPAWVNFLEHNYPDKLNLASSCKSPQGMFGS
                     IAKNYYAPKILGINPEELYVVSVMPCVAKKYEASREELSESGILDVDLSITTRELAKM
                     IKEAAIDLPNLQDQDFDNPLGKSTGAASIFGASGGVLEAALRTSYEKITNKTLDNVNF
                     TNVRGLKGIREASIDVDGTTVNVCIVNTLKNARKIMDKVRSGECKYHIIEVMACPGGC
                     VGGAGQPYHHGNTEIVDRRANALYEIDRNKAIRKSHENPDLQAIYKDFFGEPNSDVAH
                     KYLHTHYFDKSCVYGECPQECACEEAK"
     gene            complement(36959..38755)
                     /locus_tag="KR257_001358"
     CDS             complement(36959..38755)
                     /locus_tag="KR257_001358"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903750.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="mannonate oxidoreductase"
                     /protein_id="HBH0030071.1"
                     /translation="MGIEYFSKLLESSTEKELLLSKKSNNISTARLISFLIVIAGFAI
                     GFYNKNIVGIFVGVLSIIIFIALLVIHSKVKEEETYFKSKSEVLNKYIKRFGDGWKEF
                     KIDGKEYLKDENSQAKDLDLFGRASLYQYICVANTSYGKNFLAKYLWNENPDENVILE
                     RQRAIKELLSKDDFSIHIQTLSNIIGKEQKNNSDSSIESFIEYGENKNVYIPKWMHIF
                     TWGLPTATILSFIFCMLGFLPVLPVFLLFIIQLGFSGFGYPRLMQTLAPLFSFSRSIQ
                     VYEKMFEVLEKETFESAYLKELQDKLSKGSGVSRGVKQLNSIGNAVNLRYNQILYIIA
                     CGVLMWNYHCAEALERWKGIYGNQIRDWFESIGEFEALISLTVVSHVKENTCFPVIKY
                     EDTPRLKVEEVYHPLIAEKSVIANSIQLNSQTCIITGSNMSGKTTFLRSIGVNLVLAY
                     AGAPVCAKSFDATCMAIFTSMRIQDDVSQGISTFYAEILRIKSMIQYSLKELPMLVLV
                     DEIFKGTNSADRIIGASEAVKKLSKPWVISMVTTHDFELCDLSGSGDVEVVNYHFSEY
                     YVDDKIHFDYKIKDGRCKTTNAKQLMRMAGIL"
     gene            complement(38969..39898)
                     /locus_tag="KR257_001359"
     CDS             complement(38969..39898)
                     /locus_tag="KR257_001359"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416935.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HPr kinase/phosphorylase"
                     /protein_id="HBH0030072.1"
                     /translation="METSNKVSIREIIKELKLKVVYMPDDVDYYVYSQDINRPGLQFA
                     GYFDYFAYERIQIVGKTEYNFFGLMDSHIREEVLDRFFSYEIPALIISRDLEIKPDVI
                     EKAKKYKRILLSTNRNTTRLINRLSNYLDNKLAPHTTIHGVLVDIYGIGVLIKGESSI
                     GKSETALELIQRGNRLVADDAVEIRKLDESMLVGQSPELIRHFLEIRGIGIIDVRSLY
                     GVGAIKNSKMIDLVVHLEAWDETKYYDRLGLDKEYEEILGVNVEKLVVPVKPGRNTAM
                     ILEVAAMNFRQRGMGYDAAQEFTKKLSKLIDTK"
     gene            complement(39898..41715)
                     /gene="uvrC"
                     /locus_tag="KR257_001360"
     CDS             complement(39898..41715)
                     /gene="uvrC"
                     /locus_tag="KR257_001360"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009894004.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="excinuclease ABC subunit UvrC"
                     /protein_id="HBH0030073.1"
                     /translation="MFDIQEHLKKLPSEPGVYLMKDKYDHIIYVGKAISLKNRVRQYF
                     QSSKNHTSKVKSMVKNIYKFEYIITDSELEALILECNLIKRYRPKYNVVLRDDKTYPY
                     IKVTTNEDYPRILKVRRVLKDKAKYFGPYTNITAVNDTLELISSTYPIRSCKIDIDKA
                     IKNKTRPCLNLHINKCLGPCTGNVSKEEYGKMIEEIIMCLSGKEEKLMELLKEKMNES
                     SMNFRFEEAAVYRDKIKSLEEMIQKQKIDATVSDLNQDVVAMARAHNEACVQVFFIRN
                     GKIVGREHFILEGVMDSPRASILSSFVKQFYNEQEYIPKELIIEDEIEDSSILEEWLS
                     SKKGQKVTIRVPQKGEKKSLVEMVRKNAVEYLEKFSDMNKRKYEKSIGALEELKQILN
                     LEKLPIRIEAYDISNIQGVDSIGSMVVYTNAKKDKKEYRRYKIKTVIGPNDYDSMAEI
                     VDRRLKHGNLPDLILLDGGKGQVSAVKKVLELNDVDIPLWGMYKDDKHRTKGLICKEK
                     EIELDKTTNLYRFIASIQEEVHNYAITYHRSLRNKALTKSILDDIQGIGEKRKKSLLN
                     HFKDVDAIKKATMEELLEVDGMNKSIADNVYNFFRKEEN"
     gene            complement(41974..44799)
                     /gene="uvrA"
                     /locus_tag="KR257_001361"
     CDS             complement(41974..44799)
                     /gene="uvrA"
                     /locus_tag="KR257_001361"
                     /EC_number="3.1.25.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422159.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="excinuclease ABC subunit UvrA"
                     /protein_id="HBH0030074.1"
                     /translation="MEDKIIIRGAKEHNLKNIDLELPRDKFIVFTGLSGSGKSSLAFD
                     TIYAEGQRRYVESLSAYARQFLGQMEKPNVEYIEGLSPAISIDQKTTSKNPRSTVGTV
                     TEIYDYLRLLFARVGDVYCPTCGEKISQMTIQEIVDKMLDFPDRTKLQILSPIVRGQK
                     GTHKKVFDNIKKEGFVRVRVNGENYEVSDDIILNKNQKHNIEVVVDRIVIKDGIESRL
                     ADSIETAVKLSDGLVIAQIIDGEEILFSTKFACPEHGIGIEELSPRMFSFNAPFGACD
                     VCNGLGESKEVDPELVVPNKDLSIKQGAVAAWGSTGVNDDTYYSKMIKSLAEHFNVSL
                     TTPFKDLPDDFVEELLYGKDNIIVEFTYESKFGGTRNYKSYFEGVIVNLERRYRETNS
                     DYMRDKIEEYMAERPCPKCKGMRLKKEVLSVLVDGKNIMEVTNLSVNELIDFMENINL
                     TEKQRFIAHEIIKEIKGRAMFLRDVGLDYLNLSRKAGTLSGGEAQRIRLATQIGSALV
                     GVLYVLDEPSIGLHQRDNDRLITTLRHLTDLGNTLIVVEHDEDTMREADYVIDIGPGA
                     GIHGGEIVAQGTLDEIIENENSITGQYLSGKKQILLPETTREGNGSFIEIVKASENNL
                     KNIDVKFPLGKFTCITGVSGSGKSTLINDILYKGVASKVNRLKQRAGKHKEIKGIESI
                     DKVINIDQSPIGRTPRSNPATYTGVFDFIRDIFASTNEAKARGYKKGRFSFNVKGGRC
                     EACKGDGIIKIEMHFLPDVYVPCEICKGERYNRETLQVKYKDKTISDILDMNVEEAVE
                     FFENIPNIKRKLETLMDVGLSYIKLGQPSTQLSGGEAQRIKLAAELSKRPTGKTLYIL
                     DEPTTGLHMADVDKLIQVLQRLADTGNTIIVIEHNLDVIKTCDYVIDLGPEGGDKGGT
                     IVATGTPKEVSKVDGSYTGQFLKKYFS"
     gene            complement(44818..46788)
                     /gene="uvrB"
                     /locus_tag="KR257_001362"
     CDS             complement(44818..46788)
                     /gene="uvrB"
                     /locus_tag="KR257_001362"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728494.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="excinuclease ABC subunit UvrB"
                     /protein_id="HBH0030075.1"
                     /translation="MDFKIKSDFKPTGDQPEAIKSIVDSINRNEKFSTLLGVTGSGKT
                     FTMANIIQQVKKPTLIMAHNKTLAAQLYSEFKEFFPDNAVEYFVSYYDYYQPEAYVAH
                     SDTYIEKDASINDEIDKLRHSATASILERRDTIIISSVSCIYGLGDPKDYKELMLSIR
                     PGMQRDRDDVIKRLIEIQYERNDINFTRGTFRVRGDILEIFPASNDEKAIRIEFFGDE
                     VDRITEIDYVTGKIVGTRNHVVIFPASHYVTTPERIEKAIVEIENELQEQIKFFKEND
                     RLLEAQRIEQRTKYDIEMLKEIGFCQGIENYSRHITGRSEGERPYTLMDFFPDDYLII
                     VDEAHVTIPQVRGMYAGDRSRKTSLIENGFRLPSALDNRPLNFQEFEGNINQMLFVSA
                     TPGPYEIQHSETIAEQIIRPTGLLDPIVEVRPINNQIDDLVGEITKTIEKNERVLITT
                     LTKKMSEDLTNYLKEIGIKVKYLHSDIVTLERTEIIRDLRLGKFDVLVGINLLREGLD
                     IPEVSLIAILDADKEGFLRSETALIQTIGRAARNENGRVIMYADRITDSMQNAIDETK
                     RRRDIQNLYNEEHNIIPKTIQKNIRDSIEATKVAEEEVVYGISDTDDKDEIRANIDKL
                     KSEMMEAAQNLQFERAAELRDKVKQLEEKLEK"
     gene            complement(46975..48237)
                     /locus_tag="KR257_001363"
     CDS             complement(46975..48237)
                     /locus_tag="KR257_001363"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903752.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alkaline phosphatase family protein"
                     /protein_id="HBH0030076.1"
                     /translation="MTKVIVLSVDSLFEKDLEFVKNLPNFKSILENCSIVKNINCVYP
                     TLTYPCHTSMVTGVYPKKHGIYHNEKFDPNKENKDWYWYSKDIKAKTIIDVAKENNLT
                     TSSVLWPVMGANPNIDYNIAEIWAPSREDDPRETFERSSSKVIMDGIYNRHCHYIDWK
                     LEPNMDLFGVNCSVDIIKEYKPDLMLIHLATLDHTRHNYGLFNDEVDKALKMNDKWLG
                     DIIQATKDAGTYKDTNFIILGDHGHLRVDKVINPNVLLKSNGFIKVENGEVKDFDAYV
                     NSSGISAQIIVNNLDRLTELRELLEEFKEELFIENIFTKEEASNLGLEGDFEMVIEGL
                     EGISFGNDFEGSIIKDSDIKDYKFAVATHGHLPTKGNRPPFIAFGPNIKGGVVIEEGD
                     LRAHAATILKMFNLKLDGVEKEAFDFIM"
     gene            complement(48300..49604)
                     /locus_tag="KR257_001364"
     CDS             complement(48300..49604)
                     /locus_tag="KR257_001364"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891939.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="HBH0030077.1"
                     /translation="MKLKRKLATGLAITLLLGSLVGCSNSNDANASKGEKTDSNITKI
                     DFWAPLGGTNGETAQKMVDQFNSEHKDVQVNMLKQKDYYENATKLQAALTSKDQPDVT
                     LLEITQTGTFASAGALVDMSKYFDKTYQERFFSGLLTNSYYEDKFVGMPFNRSTPILY
                     INKDMATKAGLDPSGPKSWEELKDYASKMTNKSEDTYGFETPIDIWFYEAMVMQSGGE
                     ITNGKKVAFNNEAGQAPVKFWQDMMKAGIMKMPPGEDYNAWDVAKQDFVNGKVGMIFT
                     STADLAGLMQQTEGKFEISTAFLPKNQKYATPTGGANLVMLEGGTDKEKEASAEFIEW
                     MTQTDKIVQFSSSTGYLPTTEDATNSEKLQTLYKEKPQYKVATDQLQYAVALPMLNGY
                     KEATDKLMDEIKKGLTDLNANPKDVVSKGTSAMQAVIDKTNK"
     gene            complement(49635..50495)
                     /locus_tag="KR257_001365"
     CDS             complement(49635..50495)
                     /locus_tag="KR257_001365"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891940.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="carbohydrate ABC transporter permease"
                     /protein_id="HBH0030078.1"
                     /translation="MDIIQPIKKDKVDIKKIASKSIEILILLLLSAIFIFPFIWMLST
                     SFKNPQEMMQLPPTIIPNDIVLENYSTAWHSGPFFRYLLNSVFVTGSVLIVQFLVMVP
                     AAYAFSKIKFKGEKMLFGLLLVGLMIPPQVTFLPVYMMMSKFGFINTYVPLIIPFMTS
                     SFGIFLLRQNFMQISDEIIEAAKLDNASDLKIMFRIMVPMAKPAVITFILFNFIYHWN
                     NYFWPLVMTNTDAIRTLPIGVALLKSSEGITAWNVIMAGNIILILPIILVYIFANKKV
                     KEAFMYSGIK"
     gene            complement(50539..51408)
                     /locus_tag="KR257_001366"
     CDS             complement(50539..51408)
                     /locus_tag="KR257_001366"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429101.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sugar ABC transporter permease"
                     /protein_id="HBH0030079.1"
                     /translation="MKKQFNKAYLYITPAIIGTLLFIVYPIIKTISLSFKSGSLLSST
                     FENVGLNNYTELLKNPEFIQTITNTAIYTFFMVTISISLAIVLAVWLNKNSIIHNLTQ
                     SIIFTPHVISLVSVAVLWLWIMEPQYGFLNWILSTLHLPTSKWLSSESSALMSLILIG
                     IWKTLGYNILIVLSGLKSIPNYIYEASKLDNANKITNFFKVTLPLLSPTIFFLMITTT
                     TASFQVFDEISIMTQGGPVGSTNMLSYYIYESGFIYYDIGQASAASMFLLAIVMIATY
                     ANFRLLSKKVHYQ"
     gene            complement(51392..52462)
                     /locus_tag="KR257_001367"
     CDS             complement(51392..52462)
                     /locus_tag="KR257_001367"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429100.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBH0030080.1"
                     /translation="MADIRLENVTKSYNKKNTVIENLNLTIEDGSFTVLVGPSGCGKS
                     TTLRMIAGLEDITSGRLKIEENDVTKTDASKRDIAMVFQNYALYPHMTVRENIEFGLK
                     NKKVEKEKREKLITEVIDVVGLREYLNVKPGNLSGGQRQRVALARAMVKNPKVFLMDE
                     PLSNLDAKLRNQMRTELIQLHQKLKSTFVYVTHDQVEAMSMADKIVIMNKGKIMQIGS
                     PKKIYQNPKNLFVAQFIGSPCMNILDIKNDIKFGFRPEKATLESINIDGKNDDVFSLF
                     GKVVTKEVLGNETIYCLSVLNREIRVKTENDIFDIGRTLRISVLEKDLYYFDKNGERI
                     EDVKVCKSMYSKIKGDIYEKAI"
     gene            complement(52917..53033)
                     /gene="rrf"
                     /locus_tag="KR257_001368"
     rRNA            complement(52917..53033)
                     /gene="rrf"
                     /locus_tag="KR257_001368"
                     /product="5S ribosomal RNA"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00001"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: cmsearch."
                     /db_xref="RFAM:RF00001"
BASE COUNT        15561 a        10398 c         7562 g        19566 t
ORIGIN      
        1 gttacatacg aaccagcgtt ataggtggaa tggaaaaata ccaaatcgcc agcctttgcc
       61 tgcgagagtg gaagatgttg ggtagcgtca tactgggctt gtgccgttct cggtaaggag
      121 ataccagctt ttccatagca ccattgcgtc agtcccgaac agtcaaagga agtggttgga
      181 gaagaaccac caaacacata tttccaccct tgatatttca acgcttcatt cattaccttt
      241 tgtgccagct ctcccgatac ctgcggaaca gttaaatact gattgactaa ttccacatag
      301 aacatatttc catagccata ccgccagcct ccgttcttcg caacggctat cgggttggta
      361 taggttactt tctttccacc cgatttctca cgggcgaagc tctctgcaag attaaaagtg
      421 tgtttctttc cgtttcctgc cacatagccc acatagccac cgccatagtt ataggactgt
      481 atcgctacat tcaaatcgtc gatatcttga tttttgcagg aagaaagcag ggacgcaaaa
      541 tacttacacc cctgcttgat tgagctttcc gtatctaagg aactaggcgg taaaccaaga
      601 ctttctgaac tctgcataac atcttctgcc gtaccgccac tttctacttg aatgatagcc
      661 agtagtacat tgacgtactc ggagataccg ttttctctgg cgtatttttc taccatagtc
      721 tgatgtttca aaacttctgc ggataagttc atacccgtaa tgccagaaga aaagttgctg
      781 ttttcgtcgt cgctgtccgc actaatcagc accccaaaga aaagcaccag agaaaagaga
      841 ataggaaaca gacttccaat gatagcgata tgtttcagtt tcattttttc ttctgtcctt
      901 tcttcgttac aagattacgg attttctctg tggtctgctg gttcttctgg acagtctggg
      961 tctgctgaac ctttgtccta cggtctttgg tgtaattctg gcgtgtttcc tttgacacgg
     1021 taactttttc tacattctgc ctatatgtcg attgggtcgc tttcccgtca ggagtactag
     1081 aagatagcgg acgttctttg acaccgcttg tcttaactgg ttcgcttgct ttcgtagtcg
     1141 gagttgtggc agggcgtttg acttcctgca ttttttccgc acccgtcttt gaaacggttg
     1201 aagctgtggc tggtcgctca tggggacggg tagctcccgt tgtcgctgat ccgtcagcct
     1261 ttcgctgtgc ctgccttgct tcttgtgcct tttgaagctc catacgcttg acagcgatac
     1321 ttttcttatg ctgttcctgc ttttccaagc gtcccgtctg tctggactgc tgttcctgca
     1381 ccataccacg cttgaaatca gacacgctgg actttgcctt ttcctttgcg gaatacaccg
     1441 cataagcggt ctgtgtgggc atatccttga tattctcttt gacagcgttt gccttgtctt
     1501 tcactttatt tttcgtatct aagacagcac ccacctttga gcctgcacgc tgtcccatac
     1561 tggaagtggt attgccccga ttttctttag aagccgtatt ttttctttcg gctctcttgc
     1621 cagcaacggc acttccagct accgcaccag ccacaccgcc cgaaataccg ccagcactta
     1681 cagcccttgc aatacggtgt tccatacgcc tagcccgatg tcgcatgaac agatacggtc
     1741 tgcggaatat cctgcgtccc atgctttgac tgtcgccagc gttgagagaa aacatactca
     1801 ttaagtcgcc cagcttcata tagataccag cgaaacatac tatctgcaag aacgccacca
     1861 tgaaaaacgg atagtccgtg gatatgttat aaaacatact ggaaatgcta aacgcaaccg
     1921 ttacaatgag cgttattcct gcccgtgtca ttatggtatt aaataccctc acgattgcct
     1981 gctttgccat gctttcatag ctcggtatca tggaaagtag aaagctgata ggtaaaaaca
     2041 tagcgaagat aataaaaagt atctggctga acaacatcat acccgtaagc aagaatacaa
     2101 atatcgtaat accaagatta aagaacaaga ggaagaacac catacctaaa cggtttacca
     2161 cctgcggtat cgtcagattg ttgttgtcgt tgtcctcgat ttctgttttc acgacttctt
     2221 ctctggtctt tccgtcctcg tcctctggac ttgccgatac gagagcttcg acacggtctg
     2281 tcccgatttc ctctgcgttg ctgtttccaa actgtaagag tagccacggc tgttgtactt
     2341 gaatagaaaa taggctgtcc cgtatcaagt ctacgctgtc cttgccctcg ctgtcagagt
     2401 tggggagcat gatttttgtt cccaaatcaa gcgaagcggt actgatgtct gatgaaaatt
     2461 catttatctt cttgatgtag tcgggagcgt aggcaataaa cgaagcggac agcacgaaca
     2521 ccaccacaaa gttgataaca gcgtgaagtg ccttgctggt ttcccgtttt atcagtcccg
     2581 tataggcaac atacattccc accactaaga taataagaag caggaaacca acatagaagc
     2641 ccgtagaaga aaagccgttc tcggtaacgc ctgcaagggt ctgtatgctt tttccgatac
     2701 tgtctgccat atcgttaata aaatcaagtt tataggcttc ctgcaccaca tagccagttg
     2761 cattgcttaa ataaaggctt atcgtccaga caaagttggt aatgcagtaa agcccgtact
     2821 gtaccgattt tccgataccg tccagccagt tccacggaag ccacgaccag ctattatcga
     2881 cgaaaaaatc aagctggtag ttggaaagcg gatattttga atatagattt tctgcgttta
     2941 tggtatcgtc cacaagcccc gtcgcatgag ccaccgtccc cagaagtgaa agcaggataa
     3001 gggaaagtgc caccacgaac agagccattt tgagaaagtg aagtatcttc ctttttgtga
     3061 acgcactctg tatcctttct ttcatcactc cacctcattt ctctgtacgg gcggtctagt
     3121 atcaaaggcg tgtagtaatt cttcaaagac tgggtgtatc tgcaccacac cgacacgccc
     3181 gtataagtcc tgcaataaac attgtccgtt ctccaaatca cgcaagcgtt tctggttgtt
     3241 ttcgtcgtcc ttgtcgatac cgaaaaattc taaggtctgc tttatctcgt tgatgtcagt
     3301 agaacgaaat gcaaacttca aaccgatatt gtttttcaga ctttcctttg acacgtcata
     3361 ggcagactgg gtaacgaaat aaacgcctgc ctgcatagct cgtccagcac gaaccagctt
     3421 atttgatagg gtttcgcctt gtgccacatt taagaacgcc cacgcttcgt ccaaatctac
     3481 aatcttaaaa atgcttctgt ccgaatggat aaaatcaagg gcaaaggtac taatcacaat
     3541 cagcatagac accgacaata attcaatggt cgtgtattcc tcaaaagtgg tatctttatc
     3601 tggcagtaca aggtctgcta cttgaatgat attgagctgg ttatcaaggc ttatagcatt
     3661 ttctaccgtc ccgtctgaaa acagcaggtg tgcaaagtcg tagtccgtga agctgtcgat
     3721 atggtctgcg atattgcgtg agatagcggt atcttctttt ctcaattcct caataacgtg
     3781 taacagtcct ctattttcac tctgggtaac agaacgcacc gcttttcgta acacggggaa
     3841 tttttcgccg tccctagagg aaatacccgt aaggaatgtt aagatgtcga ttgccagact
     3901 ttcagcgtct ttcacattct tcataatcac aaatgggtca agaagtcctg cattgtcctt
     3961 gtcgctggta aggtttacga tattgatttc atgggctatc tctgggagcg tttctttcca
     4021 gttgccacgc tcacttttag ggtctaacag aagtgcttga ccgccaaaca gcaccgcata
     4081 atatacaagt agattgttgc agaatgactt tccaccgcca agacttccca caaaagcaga
     4141 agcaagggca ttagtaactg tgccttttac tccctgcgaa gctaaagacg gttgcaggta
     4201 cacatttctt cccgtatcaa cggaatagcc catatagata cccgtgtttt cccctaactg
     4261 ctgggtcgca ccaaaaccaa gcccagccaa gaagtctgac tttacatact gcacatagtc
     4321 attgatatat cgcttgctgg caggtaaaaa ttcagaatga agtcccaaca tatcgccagc
     4381 aggacgcacc agttttacat tgaggtcgtc gtaaaagtcc ttgacttcat cacaacggcg
     4441 tttcagctcg tcaagatcgg gtgcagacac ccgtatgacg tagcttaact tatacatact
     4501 ttctttgctc tggtctaaat cggtttccag ctcgtccacg ctgtctaaag cgtccaccac
     4561 atttgagctg gtttcacttc ctgcttgata ggcgtgatta tccaaatctt tcaattcctt
     4621 tttcttgttg cggactgtcg ttaatgcctt acggttctcc acgatttcta cattcataga
     4681 agtatcaacg gggaatgtga attgctgttg ctggaaatag aagatttcag aggacggaaa
     4741 atccaactcc ccgacaatta cattgacggt aaaataggac acatagcttt ccttgtcctc
     4801 atgttccaat cgtaaatacc gctggctttc ctcaatcaca caccttgtcg gacggataag
     4861 gtcgtagtat tttatcagcg tttctttctt caatttcttc tttggtagct ggtactcata
     4921 atcttcatag gcgataccgt ccctgccgta aagatgttcc atgagatacc caaaatcatg
     4981 gatttccaag cgacgcacct taaagcgacg ggagatttta ttttccagta acttttccat
     5041 tttcatgtaa cggttgattt catcattcgg catggaaaca aaatcattca tcagcgtgtg
     5101 gttcacttca tgaagaaatt ccttgaacgt cagccatgcc gattttttga tgttcttcag
     5161 attgagctgt tcttccgtaa ccatgagctt aaagccaaga aaaaagcggt agtccacttg
     5221 attgtcccca atcattgata ctaacgcttc ggtctgttcg tctatttttt ggactgccac
     5281 ctcacgaagt ttgcctgtta ccagtttctt tgactgctcc tgcatacttc taatggagct
     5341 ttctgtggca atctgcaacg catgaatttt tccctcacgg gactgtgcga ttagctgtcg
     5401 aaaactgtca tgcacgataa atttctgctc tgcggataga aaagaatagt tgtacggtat
     5461 catctcatag taggcgaaca cctcattgtc cttgttccag acaaggttat tgtcaatata
     5521 ttttatcggg aacatagttc acactcctta ctgccgtgat tgtttcattc aatatctgct
     5581 tatgcagttt tacggctttt cctgcataag tgattttagg tcgcaaggca taggttatct
     5641 gtgatttcaa aaagctgtac ggcttctttc cgtcaaaggt tttctgcgac ataaaccaag
     5701 tgagagcaac gggaataccg aagtatttga gaaatgctcc ctcaatcatg gaaagtgggg
     5761 gcatatcccc aaacagaatg atgataaatt ccgtaatcac aaaccatgta atctgtgtaa
     5821 aggtaacggg aaagggtaag ttaaagtcat tgattgcata taagactttt tccacgttcc
     5881 agatacccgt gtagctttta atctttttca agttctttca gcccctttcg taagttcttc
     5941 aaagagaaaa ggacagccat tttcagactg tcccttaaag agaaatacgc tgtcagtagc
     6001 aacaatgctt gttgctgatc ttccagcgtt aatatggtat ctcacagata cctcggcttg
     6061 tttcaatgaa tcgaccaccc atatccaaat ctcgcccgta ggcttcatag tcaatatagt
     6121 tctgtaagtt agctggaatg tccccaagtg cgttcaattc gtctatgtag tagtaggcaa
     6181 catctgtcat ggtttcacaa tcgggataaa aataaatatc gtccttatgt tccacgactt
     6241 cttccagcgt cccatagtgg ctgataaatt cgtccagaca ctctacgata tagtcgggaa
     6301 gttcctctat catttcatac atttcattga gttcttcaat ggaaacatat tcccctatgt
     6361 cgataggaaa gttgtcggta tcatggacag cgtattcttc gtactgttca ttcaagccga
     6421 ttttttcttt tacatcttcc tcgtcaatag ggaaagtgaa ccacgcaccg actaaatatc
     6481 cctcattgta tctgccaaga ttagcaatat aaaccgccat atcatcaatc ataagcacca
     6541 cctcatttcc tattctggca gttcaaagat actgttttcc gttacaagat agcgtttgtt
     6601 ttcaagtaag tgagaagcgt aggcttcaaa atcgaaatag tatgcttgac agtcctcgga
     6661 taaatgtttg aatgtcgggt cgttcatcag cttttgcctt gcaacatcta tcatgctttt
     6721 acagtcgtga taaacggtaa tcacgttcct gcaaatataa agtgcttcta agttctcaaa
     6781 cacggtaaga agttctacat attcttcctg catatcggct gatagctggc ggtacataaa
     6841 atctaattcg ttaagctggt acacgctggt gtgttcgtgg acttcatcag cataaggcaa
     6901 caccttttcg ataatgcggt aatcttgact ttctgcaccg acacctaact tttcttcaaa
     6961 ctctgcaaca tctatcggta agtcaaacca gtatgatgtt gtttcttcgc catttgttct
     7021 tcccgtttcc accagtaccc ttgtttcctg cattgttcct cacgtccttt ctgttgtttc
     7081 atcacatctt ttaaggtctg gtatgacata ccaaacacat atttagaaaa atctttcaac
     7141 tgtttttctt catagtcggc agggttcagc cgtttcattt catgccacac cttacgcttg
     7201 taagagggca ggtcggaaat gtattcacag ccgacttttg cctgcatatc tttaaaaata
     7261 tcgttcattt catcactcca atctgaaatt taggtaagaa aaaagcagtc aatcctaaga
     7321 ctaactgctt tgtgtgtaag tatgaatttg tttaagtgta actgatttac catgtgtact
     7381 cgtaaagttt actgtatgtt tgacttttaa ataaatatat acaatcaatc atttgtaact
     7441 tgccgtcttg ttcaaattta cttattatca gattatcttc atagatatat gctaagaaag
     7501 tatcatactc tgcatagtat ttttctctaa aaagatttga ctctctaaaa tctttttcta
     7561 aagcaattct tatactgtct aaagcatatt taaagttata acaagtatta aaactaaact
     7621 tgtatggaaa aaagaaaaat aagtttttct tgaaagtaag caatttcaca taggtttgta
     7681 tatcaaattc aatcgttcca tactcatatt tctctgtaag acaagaatgt aaactttcac
     7741 aatcataatc ccgcaacgaa gcaaataacc tagttacagt catttgtgta tttggtcttc
     7801 tcggtggaca cttaccaatt acaccatcac agaatttctg tatttgacca gtaagttctt
     7861 ttgaagcatg aagtcttgtt gtgctttcaa gtaatttaaa gtccatttga taattaggtg
     7921 agttacaatc acattctcca tgattttcag atttaggtgg tacatattct gcaaaatttg
     7981 atttttctct aaaatatatt gatttattaa ctaattccaa caagtatttt tcataattac
     8041 aattttcttc atctttaata aaatttttgt ttatgaatac tgcatgtaaa atatccactc
     8101 tcatttcatc tgaaatcata agcactttta ttcctttcaa aaaataattt atcgtaccca
     8161 cattataaca ttctcatatt acagcaacaa taaaattcgt tatgctccaa taatcttatt
     8221 gaacagctct aacagtacat ctttcacacc gccagcgttg aatactaagc cgacagcaat
     8281 aagggcaact accaagaagc caataagttt tgaaaactca cgcttgaacc ctaagtagat
     8341 accgataacc acaatcgcca taagcactaa gctctgtgca tttgataaaa accattgata
     8401 caaattttgt ccgaaattca tttaattgtc ctcgctttct tctaattgtt tcatttcata
     8461 gtcagcttct ttgctgatac tcaaaataca catcaagact acgccgatac ccattcccat
     8521 agataccagc aggaagtctt ttactaattc ccacattttt tatcactcct aactttccac
     8581 caaatctttt gcaggggtcg tctgctgttt gattatcatt tcatgctttt cactcaagat
     8641 tgcctgcttt tcaatcgttt ccatgtagtc tgtaccgttt cccttatcaa tctttttcag
     8701 cattttcaag gtcggtgcta cctgtctttg tacccaacgc aatgtgcggt ctaaggtgta
     8761 aggttctggt tttgtcgtca gtttcagact ttgccgatta tcgccaataa accaagccca
     8821 gcggtcattg agtttccagt catttttccg cttgtctggt tcttcatcaa taaaccgcac
     8881 atactggttg atgatagaaa aagcggtctg ctctgcgtca tagtaggtca gcaaatctcg
     8941 tactgcatag taagcacgtt catttctaag ccgtatctca aaacggttga taatgtcggc
     9001 ttcttccaga ggtgtaccta atttgacata ctgctcatag tccttttcat agatacagaa
     9061 atacacatct gatttcagcg aaccaagata aagggtactc cccatatatt ctctgtcgtc
     9121 ctctctgtgc ttgataagct cgcccgactg gtaatactta tagcttctgg actttccgat
     9181 atattcccgt ttcctgcatt tctccgcaag ctctggaata tccaaaatgc ccgtatggtc
     9241 gttgatagca aggtcgatac gcttcataat gcctccgtct atgagtgcgt ccataagaaa
     9301 gtcataccag cttctttgct gtgccagcag gtaactttca aactgcctgc aaccccgacc
     9361 ctttaactct aaaaggacac ctttttcttc gtcagccgac gtatagataa agatgtcccc
     9421 taatgaataa tgctccgtat aactgtaatg tccgtaatct tcatggagca tataattgat
     9481 attcagtttt aatatgtctt tgatgatgtg ctgtatatcc agcgtgggaa aacgaatttt
     9541 cacataatca aacagcatgg taagcggtgc ttctggattg aaccttgcca gttctttatg
     9601 caaagtttcc agaagttctt ttgacggctt catttttccg ctttctatct tgtttagata
     9661 ttcccttgtg ataccagaag ctaccgccag cctgccttgt gagataccgt aagcaatccg
     9721 cttctcccgt aattctttta tccattgttc ttcattcaga accatacccc caatctgtca
     9781 agtgtgaagt tttttaaggc gacttcacag ccgatttttg ctaggaaacc atgccagaag
     9841 ccttatgttt cctatgtttt tttgtctatt gtctatttgc aaacgtaccc ctctgttaga
     9901 taccgagggg ttttacctgc tggcgtggct tacgccacac cagcaacggc tagtccgagc
     9961 cgtcgccttt cgcttcgcac gtcgccgtcc cgtcctgcct tgcttgtgca agaaaaccga
    10021 ttgtctgcaa aaaatcatgt cctttcggga ctaaaggcgt gtaaaattca cttatgacgc
    10081 ttgttcccac atcacaatag ccacgccctt tgatacgctt ttggaaaaac tgctttttca
    10141 catctgaacc aaacagcata ccgtaaccta actcgctgat acgccccaat cccacacgta
    10201 aattgaagtt atctctgata ccgtccgaga aatattttgc gtctggacgc tggcaggcaa
    10261 cgataaggaa ataacctgct tgtcgtccta acatgacgat tttctttaac tggctaagta
    10321 agcccacact ttcttttgtc cccagcattt caaaaaacgc cacatattca tcaaagataa
    10381 gaaagcaggg tggcagtccc agataggcgt aattttcgcc cgtcttatag ttcgggtgtc
    10441 gtttcatttg ctcgcttcgc tgtaccatgc cctcataaaa agcattgaca cagtctatca
    10501 tttcttcttt ggtgtgatac acgtttccca tgactgttcc caagtctgct aagtccgcat
    10561 ttttcgggtc taagatgtaa aggacagcgt tggtatgcag tagggcttca atgagcgtca
    10621 gaagaaaata tgttttaccg ccaccagtcc caccagcaat cagagcgtga gggagtgcgt
    10681 catattccca gacaagattt ttcatcagtc taagacagcc gttctctgcc cgtacttcat
    10741 caatggtaat gcggttcgct atcatatcat aaagcagggt atattcgata tagccgtcat
    10801 gcagggtctt gtcggtcagc tcacaataca agccactttc caatttatcc tctaaccgta
    10861 aaagctggtc ttgatatttc cccagcgtaa tttcacagcg gatatgaagc agtccctttt
    10921 ccatttgata ataaatcttt ggaaaccaga cgattttttc ccttgatctg ctttgcaggt
    10981 cagtaaaaaa aacgctgtct tgtacggtat cagcttcata ccacttgttt tccagtatca
    11041 ttcgtgccag cttttgacgg tgcagtagct ttttgaaact gtcgtaacag aagcggtaat
    11101 acagaaaagc gaccaatgca caaacaccag tcgctatcag tatggttatg aagttgtaaa
    11161 gggaaagcgt aaagccattg tctaataagc tgaaatgttc ccagtcggta cgcatgagct
    11221 gttttgtatt taatagcagg ataaccgcta cgaacacaaa caggagtgtc cccattgaaa
    11281 agcgatagac aaggttctta tcgctggctc tgatacggtg tcctttgttt aaaatcattc
    11341 tcataaatca atcactcctt tctgggtatg aaaaaagcag tcaatcgtat agactaactg
    11401 ctttgtgtgc atggatatga agttgtcaaa ctggaattta acgttcactc atatattgtt
    11461 ttatttcatc agaagtcaat tttcgtactt ctgtatgtgg atattcttta tactctccaa
    11521 cattaaacac aggtgtcatt tgtttgcatt tcttgtcttt attctttttc aagaatagat
    11581 gtaaatcctc attcccggcg aatattttat aagatactct gcctttactg ttctctatct
    11641 cataaatacc acatgaactt ttcgttgtat aatcggctgt tcgtaaataa agttttgcaa
    11701 tttccaatga cttaaaagga aaattccatc tttgtaatcc tctgtttggg tcatgttcaa
    11761 tacaaatgca acgtccacaa gttccacaaa tatattgagt gtggttttct aagcagtcca
    11821 agggatttag taatggtgtt attctatttt catcagagta acattcttca cacatttttc
    11881 ttttcgctcc ttatcaaatt ctaatttgtc gctttcttca tacccatatt ataacagttc
    11941 cgtatatcct ctacaacgaa aatctattca gcaagtctat tttttcggtt gtccctgcgg
    12001 tgtatggttc tgtgaagtgc ctgtgttctg attgccttta ttcttcagta caatatcttc
    12061 tgcctttaca taccagtcca catctgcacc cgtataggtt tttcgtgata ccgtatcggc
    12121 tacgggattg acaagctcca cgactgcatt gtaaggaaat tcccttaacg gtacttctgg
    12181 cggtacggac acggggataa ttccaccatg cagactgcac ttcaaatcat agatacgctt
    12241 tttaagctgg gtactcggtg tcccgtcctc attttgcaag aacacatcac gcaccgctgt
    12301 aaattttaat tctccaaatg ttttctcttt gtcaatgaca aatccatttg ataatctcat
    12361 aaattcttca ctcctttact tttcttcaac tgctacaata tcatcagcta ctaatacata
    12421 atcggtatgt cccacatccc cgattgcgta ccctctgccg tataacttcg gattgacaag
    12481 ttttactttc tgttcatact tgaaatgctt ttcgccagcc tgcacgggaa tttccaccac
    12541 aacattttcg cctttctgta cgtcagaata aaggttatag cttcgtctgg ctatgacctt
    12601 gcggttgttt ttatcccttt caaagatagg ctcgctttcg cctgcaaatt caagagttcc
    12661 aaaagactgt gccatatctg gcacgacata tttcatttcc atattgtttt acctcgtttc
    12721 tttctatatt tgataagttt atgattgtaa ttttttattc tggcttgtct gccgtttgac
    12781 agtttcggcg gagaacgtga tttttctttc atcataccgt taccgcctta tgattttttc
    12841 attgtacggc gtttgtaaag atatgttcca gccagtccac cagcagatgt aagcaacatc
    12901 acaagaaatg ccatgacatt tgtactgtcg cccgttttag gactgtcgct aggtctgttt
    12961 ggcttttctg gtgtctgcgg tgtttcgagt ttctctggga cttctggttt ttcattaaaa
    13021 gtaatcgtct gtccctcgtc ctcaatatcc ttatgctcgg taactttctt cggctcgtct
    13081 ggattgctta aatcatacaa ttcttcaaaa gttacaagct gtttgccgtc aagggaagta
    13141 gcgtcaaagg taaaggcaac ttccgctttc atagtttcgc tgtcagcggt aaaggtgtaa
    13201 tcactttcca cacgtttccc attgataaga agttctgcat tttcttcttt caacatctgc
    13261 cagcctacaa gtttgtactg tgtaccgact tccaagccct ctaaggttac ggtatcaatg
    13321 attgtaacgt cttttccagc ttcaatctct ttgttgccgt ctttgtcggt agcagtcgta
    13381 tgtatcttga tgatacgttc tgtaatcaat acagtttgtc cgtcgtcctc aatgtctttg
    13441 tgttccgcaa ctttcacggg ttcgtctgga ttgcttaaat cgtataattc ctcgaatgtt
    13501 accagatttt taccgccaag ctcggacgca ttgaatgtat aagaaatttc cactttcatt
    13561 tcttcatcat cagcgataaa agtatagtca ttttccacac gttttccgtc aatgataagc
    13621 tctgcatttt cttcctttaa catctgccag cctttgagct gatattttgt accttttgta
    13681 agcccgtcta atttgacagt atcgacgatt gttacctctt ttcctgcaag gatagtcttt
    13741 tcgctgtctt tgctggtcgc tgtggtatgg atagagattt ctttttcgta ttcatcagtc
    13801 aaagtcccta aatcaatcac aaggttattt cttgatacca cgatttcaaa aggtgggata
    13861 agttcaaagc ctttgttact atcgcaacgc atttcttcaa tgatgtaagt atcataaggc
    13921 aatgcacctt tgctgtcgtc tgcttcagaa gttccaaacc acacaccgtc ctcgctggtc
    13981 ttgcctgcgt tagtattgtg cttatgagaa gtccattcag cagaagtgga gaattgcccg
    14041 ttatcatcag taactacaac atgactttct cccgtcgtct tgcttgtgat cctaaaggga
    14101 acatcagcaa gacgcttgtg tgtgcctgca ccgattttca ctccctcaat atccccacgc
    14161 ttaatctgat tgtagataga gtgggcttcg tcggttaagt ccacgatttt tccattctct
    14221 gtgattgcaa agtcaatcgg cttcgcaccg tctgtcaagt aaccgtcggg agcttcactc
    14281 tcaacgatac ggaatttccc ataaggtaaa aggtcagcag aagtagaagc cacaccctca
    14341 atatctgtac gaattgtctt taccacttca tttttcttat atagcttgcc ctcaaccaaa
    14401 acagaattgt catttaagga aatgacgtca aaagcagtat ctttcaaagt ggcacttcct
    14461 tgtggtttgg tatcgctcgt ttctaaatct cttttctgaa ttttcacacc gccacggata
    14521 accttgtctg atacggaaaa ctggttactt cccgtcaata cagcaaggtc gccgtcctct
    14581 gtaatttgtg taaggtataa gccttttatc tgttcagact tatcgccagc ctgcatatat
    14641 gcaccgtcca gcaagtagcc gtttggagct tttgtttcct caacagatag tgttcctaaa
    14701 ggaagaatcg ctttgccgtc ctgcatatag aagctgtcgc cagatacctt gtaagcgtcc
    14761 gctaattttg tgatgtagtg agttgtcccg tcactgtctg tttcagcgat tgtctttgta
    14821 acccatgtac gagtagcttc ggcagggaga ttgtctttgt tatagaagcc agcataatac
    14881 ttccatgtaa actctgcacc ctctaaagaa gcgtttccct gcggattgtc tttctgcgtt
    14941 tccatatcaa tcttgaaaag ctcaatcaag gtgtccgtta cttttggtgt atctgatacg
    15001 ttcaaggtcg ctgtctttcc agcttcaact tttaaggaat acacggttgt atcaacttta
    15061 tatcctgctg gtgcggataa ttccctaata tagactgtac ctgcttttac ctctacaaca
    15121 tctgtatttc cgtttttatc agtcgtaagg gtggcaagct gtttcgtgca gtccttatca
    15181 gaaaagacac cataggtcgc accagcgatt gagtaattcc cgttaccgtc tgtaatgctg
    15241 gtattactgg aagtcttttg cagttttgca tttccgacat ttaacttcgc ccagaattgt
    15301 cccaattcct gcccctcgcc agagtagata taaccgccac attcatagcg tcctttattt
    15361 tctttcacaa aggctttagc accagcgaaa acttcgtcct gagttgcttt tggtatttca
    15421 tcataagaag ctcgcacgtt gtcgcattgc cagccaagat gtacgctcaa tctctgccag
    15481 acaacacatt gttccaacag atagacttgc ttgtagttca attccttgtg tgcttcgcca
    15541 tactgtttga catactctaa ggataacgcc acatctgaaa tctggtcggc actcatacgg
    15601 gtgcttgcgt cagctctggt cttgtagcca ttcttaaaat ctgtattgat gtctatacag
    15661 taagcgtcct cgccctcaac agtcaaatgt ccctcgttaa aggtagaacc aatcgaaccg
    15721 tcattcatta ctttttctac gataccgaca cgttcctctg attccgtcca gtattgcttg
    15781 ctttctgcat ggacggcggt actcggtaaa gcagtaacga cagtcgcaaa ggcaagtact
    15841 cccgtacaca atcgtttcaa tatctttttc ataattctaa atgctccttt cattttgggt
    15901 aaaaaaatag acgctcaata ttgaacgtct tacattgaaa agggatactt tttacaagta
    15961 cccctcaaat ctaatattta attgtttgtg ttcccacact ctatatcaac aactactgaa
    16021 acattgatat agttttttat ctctttattt ctgattttat cgccctcgct cgtaaagact
    16081 atatgcttaa aaaagtgcct aaaattaagg atttctacat agttcgtctt tgtagcaaca
    16141 cacaagtctc tatatgtgta gaatgaggga acatatctac aggttgtgcc tcaacacatt
    16201 taaatccgtg aacatttaga taatctaaat cccttgctaa agtagaagga ttacaagaaa
    16261 catagacaat tctttccgga ttcattgaaa caatagtctc taataccttt tcgtcacatc
    16321 cctttctagg tgggtctaca acgactacat tggcagtctt accctctcta tacatcttag
    16381 gtacaatttc ctctgccttt ccaacataaa attcagcatt atgtatattg tttaatttag
    16441 catttatctt agcatctttt atggcatcat ctataatttc tattccataa acctttttag
    16501 ccttttgtgc caaaaataaa gatattgtac ctatcccaca gtaaatatca aaaacagtat
    16561 cagtatcatt taaatttgca tattcaagag ccttatcata caatacttta gtttggacag
    16621 ggtttacttg gaaaaatgat aatggtgaaa tctcaaacac taagtctcct atataatcgt
    16681 ttatttttcc atctccatat ataactatat tttctcttcc tagaatagca ttcgtatctt
    16741 tttgatttac atttacaacc aaagtcttaa atccaggtat attttcctta agcactgaag
    16801 ctaattcttt aagatatgga agtttgtttc catttgctac taatacaacc attacttctt
    16861 tagttgtaaa acctattttt gttactaaat gcctaatcaa ccccgtgtga gtcttttcat
    16921 catatatgct taccttatag gcccttatat atgtttttat tattttaaca attttatcat
    16981 ttatctcatg ttgtattacg catttttctg tcgatattac atcatgagtc ttctttttat
    17041 agaagccaat aattggaata ccattattct tttgtattgg aaattgtgct ttatttctat
    17101 atctatatgg attatccatt cctatagtgt catgaacttc tacatcctct aacttaccta
    17161 ttctcgaaag tacttgttta acttcatttg ttttcatttc aagttgttta ttataatcta
    17221 agtcttgtat ctgacaccct ccacaatccc taagattgtc actacacact cttttcaccc
    17281 tgaatggaga cttttctatt atctcaacaa tatctcccac agcataattt ttctttactt
    17341 tattaatcct aactttaact ttatcatgta ttaatccgcc ctctacaaaa actgtaatac
    17401 cattgtactt tcctactcct actccgcctt gaccaatgtc tactatatct acaatataca
    17461 tctcgttttt cgaaagcata aatcaccctc caatcaatct attatattta aatctttaca
    17521 aacttttttc tttaaattta tattaaaata ttgctattaa ttaaactata ttttttacta
    17581 agctacaata ttttatttta ccaaaaaaaa aggagcttat aaagcccctt agtaaataaa
    17641 tttattattt ttcttataaa actctagttg aacctctata taccacgcct cttgatgcat
    17701 ccacagttac aacttctcca tcttttacta gatttgttat atcagctgca gacacaataa
    17761 ctggtatatc taaatttata cctacaatag ctgtatgtga tgtcattcca ccattctcag
    17821 ttactacagc tcctgctttt tctatataat tgttcatttc agcatcagta gcagtagaaa
    17881 caagtatgtc gccttcatta aagtctacac aagcatttcc attctttatt atacgaactt
    17941 taccttctac tgtttgagta cctacaccta taccttgcac gatttcttcg cttattacat
    18001 gaacctttat taaattagta gttccactta ctcctactgg tactccagca gttataacta
    18061 ctaattcccc attatctata taatcagctt gtctagctgc ctcaattgcc ttttctataa
    18121 cttcatctgt atttcctgca acagaagact taactggata tactccccat gtaagagcta
    18181 atttattcat agtcttttca ttatttgtag tagctattat tggagatttt ggtctgaatt
    18241 tagataccat tctagcagta tatcctgaag aagtagatgt tattatagct gatgcattta
    18301 aatctactgc tgttgtacaa gttgcatggc ttattgcatc tgttacagta acattgttag
    18361 taccattttc ctttagtaat ctatcataat ctaaagtctc ttctgttctt tttgctattg
    18421 tagccatcat ttttactgcc tctacaggat attttccagc agcagtttct ccagataaca
    18481 ttatcgcatc tgttccatca tatatagcat tggcaacgtc tgtaacttct gctcttgttg
    18541 gtcttggatt tcttatcata gaatcaagca tttgagtggc agtaacaact ggctttgcta
    18601 attcattaca tttttttatc atcatttttt gaactattgg catctcttca gttggtatct
    18661 caacacctaa gtcacctcta gccaccatta taccatcaga aacttttaat atttcatcta
    18721 ggttctctac accttcttgg ttttctattt tagatattat ttgtatatca gttgcattat
    18781 tgttctctaa tacttctctt attgctagta catcagatgc ctttcttaca aaagaagcag
    18841 ctatataatc tattccttga cttattccaa actctatatc acttatatct ttaggagtta
    18901 ttgctggtaa atttatctta acaccaggta catttactcc tttatgattt ttaactattc
    18961 ctgaattttc aacaacacaa actatatctt ctccatttat ttcttttact cttaagccaa
    19021 ctaaaccatc atctattagt atagaatctc ctgatttaac gtcttcagca agacctttat
    19081 agcttactgt acacatttct ttagtcccca taatatcttt catagttata gtgaactttt
    19141 gcccttcttc taaaaatacc tctgggtctt caaagttacc tgttctaatt tctggacctt
    19201 tagtatctaa taatatagca actggcttat ttaatttttc tctaactttc tttgccatat
    19261 caattctttc tttatgttct tcatgcgaac cgtgagaaaa gttaaatcta cacacattta
    19321 gaccattttg cataagttga gttaaaactt cctcactttg tgatgctgga cctagtgtac
    19381 aaacaatttt tgtcttcttt acattattta acatatttgc tcctcctgag atattattcc
    19441 acagatttat ttttaatact aaaacttata tagataatat ttttgccatc tcataagctt
    19501 ctttatcaaa tactttcttt tgagctaaag cttcacttat ttctaaatca attattttgt
    19561 tttcttttat tcctacaact ctagctgatt ttccatctaa taataattct actgctctta
    19621 ctccaagtct acttgctagt attctatcag atacagttgg gcttcctcct ctttggacat
    19681 gccccaatac agtgactctt aaatctgctc ctgactcttt tttaagttcc ttttctaaat
    19741 cactagcact tccgactcct tctgctaaaa cgattatact atgtctctta cctctttttt
    19801 gagtagtctt taatcttaga gcaacttcat ctactgtaat ttctacttct ggtactatta
    19861 tagtttccgc tcctcctgca agacctgcat ataaagctaa atctccacag tgtcttccca
    19921 taacttctac tatgttaact ctttcatgag atgatgatgt atctcttatc ttacctatag
    19981 catctataat agtattcatt gcagtatcaa atcctatagt ataatctgta tatgctaaat
    20041 cgttatctat agttcctggt atgcctatag ctgggaatcc taagtcacta agtttttggg
    20101 ctcctgcaaa tgaaccatct ccaccaatta caactaagca atcaatttta tactttttaa
    20161 gaatttttac tgcttttaat ctaccttctt ctgttttaaa ttcttcacat ctggaagatt
    20221 ttaatatagt tcctcccctg tgtataatat ctccaacaga agataagttc atttcagtta
    20281 aatcttcttc tagtaatccc ttatatcctc tattgattcc atatactttg catccataat
    20341 atattgctga tcttacaacc gctctaatcg cagcattcat tcctggagca tctcctccac
    20401 ttgttagtaa tcctatagtt ttcatttttt acctccttgg attttatgtc aattttttat
    20461 tataatcatt gttattgtat tctaatggac tttttttgtc cctatatcac tttttaatcc
    20521 catcaagact aaaaaaatta aatgtcctta aatgtccatt ttgtgatatt atatcacaaa
    20581 acggacaata tttttcatat tattataata tatttagatt tttatataaa aaatcaagct
    20641 tttactttta tgttatcttt aggaagtaac tcttctaagt tatttataaa ttcatcacat
    20701 atacaagtca atgccccggt cattttatat gctttacgtt taccatttat attttcatcc
    20761 atagggtata agtatatact gtcattacct ggatattgtt tggctatttc tacaatatta
    20821 ttagttgtat cagtatcaga catactatct attttcaaat acaatttttt accactttct
    20881 ggcttaatat tttctacatt tctagttctt cctgaattgt agtttctatc tgcaaagtca
    20941 gtatcatcat ttatatcttt tatctctcta gctataagtt ttgcattttc gccttctttt
    21001 atacttaatg ttccttttac atatattata ttatcttcat tcaaaatgac attatacttt
    21061 tgtaataatt gaggaaaaac tattatttct atagcaccat acaaatcttc taattcaata
    21121 aatgccataa tttcatttcg ttttgttgtt ttaatagttt tagttacaat cattccaccc
    21181 attataacat ctgtttcatt catttgtagg tatgactctt cttcctcttt taatgaattt
    21241 aattttccat tatccataga tgttttttct tgtagttctt tttcaaattg tgataaagga
    21301 tgtccactta catacattcc caagacttct ttttcaaggt taagtctctc tctttcttcg
    21361 tactcttgcc ttttaggcaa actgtatatt tgttgaaaat cactatcttc ctcactatct
    21421 ccaaaagcat caaataaaga aatttgacct tgaacatttt tctttctatc catagataca
    21481 ctttctaata aactttcata accagccatc agactagctc tattttcact tatattatca
    21541 aaagctccac attttattag actttctatt actctcttat ttgtatcttt ttggtctaat
    21601 cttttgacta aatctactaa atctacaaat aatccattag attctctttc agcgattata
    21661 ttgtttatta tatttacgcc aacatttttt acggctgcta gaccaaatct tatattgtcg
    21721 ccttcaactg aaaactttga aaaacttttg tttatatctg gaggtaatac atctatttct
    21781 agtgctttac attctcttat atactcaact accttatcag tatttcccat tacactggtt
    21841 atcaatgctg ccataaattc aactggataa tatgttttta gataagctgt ctcatatgct
    21901 aaaaccccat atgcagctgc atgtgattta ttaaatgcat atctagcgaa gtctatcata
    21961 tcatcaaata ttttattagc tatttcctct tctacaccat ttctgataca ccctgcaatt
    22021 tctatattac catcttcatc aaatttacca tgaataaaat attgtctttc ttcttccatc
    22081 acgtccatct ttttcttact catggctctt ctaactaggt cacttcgtcc gtaactataa
    22141 ccacctaaat ctctaacgac ctgcataacc tgctcttgat ataccaaaca accatatgta
    22201 acttccatta taggctttaa tttttcatgt agatatgtta catcttttgg gttgctttta
    22261 ttttttatat atgcaggtat agaatccatt ggacctggtc taaataggga tattcccgct
    22321 acaatatctt caaaattgtc tggttttagc tgtttcataa aacttctcat gccagcactc
    22381 tccaattgaa acacccctag tgtatttcct gatgaaagca tttcatatac tttcgggtcg
    22441 tcataatcca tctttgaaaa gtctattttt tctgtgtaat tttttataac tctatttttt
    22501 tctattaaat caagagtatc tcttataact gtaagagttc ttagcccaag aaaatccatc
    22561 tttaaaagcc caagttcttc aagtgttgtc atagtaaact gtgttgtgat tgcatcttga
    22621 tgtttgtaca aaggtacata ttcatctacg ggattttttg atataacaac tcctgctgca
    22681 tgagtagaag catgtcttag cattccctct atctgttttg atatatttat tatttctttt
    22741 gtttccgggt cttggtcata caattcttta agattaggat ttgtatctag ggccttatct
    22801 attgtcattc ctaaagcaaa tggtatttcc ttggctacct tgtcaacttt attgtagcct
    22861 atatccaata cccttccaac atctcttatt gcagcttttg cacccattgt tccaaaagtt
    22921 attatctggg ctacatggtc atcaccatat tttctcttta cataatctat aacttcttct
    22981 cttctctcat aacaaaaatc tatatctata tctggcatgg atatacgttc tggatttaaa
    23041 aaacgctcaa ataatagaga gtactttatt gggtctatat cagttatttt aagtgtatat
    23101 gctactatcg aaccagccgc actacctcta cctggtccta ctataatatt attttcttta
    23161 gaaaaattta taaaatccca aacaattaaa aaatactcta cataacccat tttttcaatt
    23221 acatctaatt cataatttaa tctctctagt atctcattac taggattatc atatctctct
    23281 tttaatccat taaaacacaa ctcccttaaa taagtttctg gtgtatatcc ttctggaaca
    23341 tcatacttag gaagatgtat agtattaaaa tcaaactcca cattacacat atcagctatt
    23401 ttcacagtat tgtcaatagc ctctaatgca tatggaaata attcttccat ttcttctctt
    23461 gattttaaat aaaactcatc actaccaaat ctcattctat ttgggtcatt taatgttttt
    23521 cccatttgaa tacacataag tacatcatgt attttcgaat cttctttatt tacatagtga
    23581 acatcattag tagcaactag tggtatacca gtctcttttg ataattttac taaaccagag
    23641 tttacttctt tttgctcagg taaattgtga tcttgaatct ccaaaaagaa attttcttct
    23701 ccaaatatgt ctctgtagtc aagagcaaat tgttttgctt tttcataatt tctattcatt
    23761 aaagcacgtg ctacatctcc tgcaaggcat gcagaaagtg ctataatccc tttgttatgt
    23821 tttttaagtt cttccatgtc aactctaggc ttatagtaaa aaccttctac gtatgaagtt
    23881 gaaactattt ttattaaatt tttatatcct tccatattct tagctaacag aactaaatgt
    23941 ccttgatatt tgtcatagtt tgggtcttta tctctcaatc cacgtgcagc tgtatagact
    24001 tcacacccta taattggctt tattccttct tttatagctg ttttgtagaa atctataaca
    24061 ccaaacatac aaccatggtc agttatagct attgagctca tgtttagttc cttagccctt
    24121 tttataagtt ttttcaccct cgaaaaccca tcaagtaaac tatactcagt atgtacatga
    24181 agatgagcaa aatctttgtt cattaaatca cctcctgctt tataatttta attttaccac
    24241 aaatatatgt cctaaaacaa aaacagagac ttttatctca aaataggaat taacttcaac
    24301 atataccatt atatgttata aattaatgct tattctgaga ttgtcccctc aatttattgc
    24361 tatgattttt ttttcaaatc tgttgcaatt tcttctattt ttctaagtct atgattgact
    24421 ccagattttc ctattggtgg ttctaacatc tctccaagtt ctttgagagt catatcctca
    24481 tactcgattc taatcttagc tatctcttgt aaattttctg gcaaactgct aattcctata
    24541 gtctcttgta tgagcttaat attttctact tgtcttactg ctgcatttac tgttttagaa
    24601 aggttagctg tctcacaatt tactatcctg tttacattat ttctcatttc ttttactatt
    24661 ttagtatttt gaagacttaa aagagcgtgg tgtcctccta taatactcaa caaatctgat
    24721 atttgttcac tctctttgat ataaacaacg tgattatttt ttctagccac aattttacta
    24781 ttaaaaccta aagagtttat aagttctttt agagaatctg caaactcctc attattagtt
    24841 acaaattcca tatgatagtt cttttctggg tcgcttatag aacctccacc aagaaaagct
    24901 cctcttatga aagctctctt acatccttca tgcttaatta agttctctga aattttgttt
    24961 atagtaaaaa atccttcttt atcttcaagt atacctaact tttttaataa catttctgaa
    25021 cccatttcgc ttgttaccat taatacataa ctgttatttc tctttagcat ttgattctta
    25081 tttactgaga ttgtagtatt gatattaaaa ttctttttta ataatttaaa tactttacgg
    25141 gctattgaat ttaactctgt tgttatcttt agatttagct tcttatatcc aacaatttgt
    25201 atacttcccc ctgatttaac tagagctgac aattcagcta tattacaaca ttcattccca
    25261 gatataactc ttgctagttc atttttggtt tcagttgaaa aagacatatc tatcacctat
    25321 taactaattt ttctttaacc ttttttttat ttcttgtaag gcaaccttta ttatctcctt
    25381 ttcatcatca tacctagcta agtctactac tctatctagg tggataaatt tagcatcaat
    25441 aaagccttcc tctttttgtg gaatagtatc catattcttt gcttgcatca aataccaaaa
    25501 aactgtttta tgaactgctc tattttcatc ccagttttct ttgaatgtat agtgtatttc
    25561 acctaaatat ttcaatatat ctgcttttac tccagtttct tcacttactt cacgtaatgc
    25621 tgcctcttgg ttattttccc cttcttctac ttttcccttg ggtaacaccc aatctccatt
    25681 gaacttcctt agtaaaagaa tcgtattgcc aaacaggact acaccaccag cactaacctc
    25741 ttctctcatc gatgttcact ccttaaaact aacataatga taaggatttc tacacaattt
    25801 tttaaaatcc ttttttacta acttttgttg taattatgat ttagggctaa ctcaataact
    25861 atgttagata tatactttgc atcatgtctt atataattat tttttatttc aattaaattc
    25921 ttctctacag tttttatacc catctctttt aatttatctt tttgcttttt atctaacaag
    25981 acttgctctg ctccatcttg tttatataag tcaagcattt cttctggcaa tatctcatta
    26041 tttgcgatta cataatctat taaattctca tcagtgtgtt ttactatagc attaacatgc
    26101 tctaatacat tgtacccttc tgtctcacct ggttgagtca ttatatttgc tatatatact
    26161 tttggagcta cagacgattt aatagcgtct acaatcccct ctacaagtaa attgggtatt
    26221 atacttgtat ataaacttcc aggacccata attataatgt cagcatcata aatagatgca
    26281 ataacatcct ttaatggttt tacatctttt ggatttaaaa aaattttatc aatagagctt
    26341 ttttgaattt ttgactcttc aggtatacta gattctccat ttattatatt gccattttct
    26401 aatttggcaa ctaaatttac atcttccaaa gttactggta aaactcttcc tgttatagca
    26461 aaaatttcac ttaatttata tacagctttt tcaaagtttc catacaaccc attcatagca
    26521 gccaaaaaca aatttccaaa actctgacct tttaaaagcc cttctgtaaa cctatattgc
    26581 ataacttcat tcattgttgg ctctatattt gcaagtgcta ataaacagtt tcttatgtct
    26641 cctggtggga gcattcctaa gtcttctctc aatacacctg aacctccacc atcatcagca
    26701 acagttacaa ttgcagttat attttgcgta gtgtgtttaa gacctcttaa aaataccgat
    26761 tgaccagtac ctccacctat cacaaccaca tttggttctc tattttcaac aatagacctt
    26821 tgaaatagtt ttactttttc attttttgct tttttatata taaataacga tacaattaat
    26881 gcaatccaac ctaaaattcc tacaataata agtaatttag ccatgtttgc ctccattatc
    26941 gcaacataga gtctctatgt ttctttacaa ctctatatcc cttattagat aaatcctccg
    27001 ctataagatt tgttatagta actgacctat gtcttccacc tgtgcatcca acaccaatta
    27061 ctagatgttg ttttccttcc tctatatatt gaggtactaa aaaatgaatc atatctaaaa
    27121 gtttcacata aaattcttca ctgattttag aattcataac ataatctcta acttctttat
    27181 catcaccagt tttagctctt aactcttcaa cataataggg atttggaaga aatcttacat
    27241 caaatactaa atctgcatca gcaagtatac catgtttaaa tccaaaagat actacagaaa
    27301 tagttaggtt tggattatct tcacctgaag aatatatttt ctttatttct tccttaaggt
    27361 ctttaggttt catgttagtt gtatcaatta tacatgtaga taactccttt aaaggttcca
    27421 ttatctttct ttccattttt ataccttctg gaatctgcat atcttttgcc aatggatgat
    27481 ttcttcttgt cattttatat ctctttaaca atacatcatc attacaatcc aaatatacca
    27541 tttcatattc ataattttct ttttctaaat aatttaagct ttcatgaagc gcttcaaaaa
    27601 actttctccc tcttatatct atccctagag caactttatc aatacttgaa tttggttgat
    27661 aacataattc tgcaaattta gttatcaaag caggaggtag attatctaca caataaaatc
    27721 ccatatcctc taaagctctc attgtctcac tttttccaga tcctgaaaga cctgtaacta
    27781 taacaaattt cattgctaac tcctcccttt tatcttatgt ttattatatt ataatgtttt
    27841 ctactaacga tatatccaga ttagagtcag atatagtctt catagctagt tcaaaatcac
    27901 caactctttc tggacaatgt gcatctgagc ctattataaa tttattttct agccctttta
    27961 ttttatttaa ttgatttaca ttcaaaaaag aatggctact atttatctca agtctagtat
    28021 ttgtcttttt tgctgtcttt gctacttctt ctatatacac atcgccttta tctcctggat
    28081 gagtaattat aaaaatatca ttattactta tcgcatttat tacagctttt gtattatatt
    28141 cttttgcttt ttcagtttta aaaatatagt tattacaatg atttaataag cttcttaatg
    28201 atgttggagt agaaccaaaa tgatatccag ccataatata atcaaaatct ctaataaatt
    28261 tatcatccat atctatattt cctttatcat ctaatatgtt acactccata cctaaaagta
    28321 tatttatatc agtgtactta tcatttaaat aatctacttc ttctctcatt ttgagaatat
    28381 cttttttctt tacaccatat gcaatatgtt tataactatg gtcagatatt cctattgttt
    28441 ttattccttt agaaatggct acctttacat tatcctcaat agtccctttg ccatgactat
    28501 ataatgtatg tgtatgataa tcagccagta ttttcatttg ttaatcctct ccaagtattt
    28561 tgacttcttc ttccaacata accccaaact tggcatatac agcacttttt ataacatata
    28621 ttaaatccaa aatatcttta gcacttgctt ctccttgatt gactacaaat ccacaatgct
    28681 tctcagatac ttgtgctcct cttaaagtaa gacctctcaa tccagtttct tctattaatt
    28741 tacctgcaaa atatcctgtt ggtctcttaa atgtacttcc tgcactagca aaatttaatg
    28801 gctgtttagt tattcttctc gtcgctaaat catccattaa actttttatt tcatcataat
    28861 ttccttcttg taattccaat tctgctgata aagctatata tccgtttttc gatattatac
    28921 tttttctata cccaaattcc atctgttcat ttgataattc aaatatattg ccttccatat
    28981 ccatcagtct tactgacttc actatgtcct tcatttcacc accatatgct ccagcattca
    29041 tggctaatgc tcctcccaat gtgccaggta ttcctgatgc aaactcaaac ccttttaatt
    29101 cttgcttttg gagagctttc cctaaaactg ataataaagc tcctgactga gcagtcatcc
    29161 tagtatcatt tatctcataa gaattgaaat tatcagctag ttctattacc actcctctta
    29221 ttccaccatc tttaattaaa atgtttgaac catttccaat tattaaatac ggaatagatt
    29281 cttcttttac caacttaagt acatttttta attgttcttc agttctaggt ctaactaata
    29341 tatctgctgg tcctcctacc ctaaatgaaa tatgtttttt cataggttca tcgactttta
    29401 tatcctcttt acttaatata tttaataaat ttatatatat atcttgatta ttcattgtat
    29461 ttcctcccaa attatactga actttagctg tcattattat ttaaattaca ttagtatata
    29521 gtattaacta tattcaataa tatatgattt tgcttatcat atggatttta tattttaagc
    29581 ttcttaatta caaactatat tcaataaata tataataaag taaaaaaaaa aaaataacaa
    29641 catataaaag aatataaata atttaaaaaa agcatcaata tcactgatat caatgcttta
    29701 aaaggcaatt taattcgtat tatttatcta actatttttg acatagcaaa gataataaat
    29761 ccctccaact actatggaac ctccaacgat atttccaagc gttacaaata ccaaattagt
    29821 tataaattga accatagtta tatttgctcc taatgccatt cccattggta taaaaaacat
    29881 gtttgcaaca ctatgttgga atccacataa tacaaatagc attattactg tccaacatga
    29941 agccaatttt gacattatat cttgagatgc tgtagccatc catacagcta aaacgactag
    30001 aatattacaa agtattgctt ttaaaaacat tgatgctata gttgaattaa ccttagcttc
    30061 tgccacagct atagcttttg tagctgcatc tcctgtcaat gtagaagaat aaaacacaag
    30121 tgcaactagc aaaattgaac ctactaaatt tgcaaaataa accagtcccc agtttcttaa
    30181 catttttcct aatgttattt ttttgtccat aagtgcaata gccattaagg tgtttccagt
    30241 gaataattct gctcctgcca ctactacaag cataagacct actggaaaga ccatagcact
    30301 taaaaagcta gctacccctg ggtctatctt gccaaaagtt tgactaacta tcatactccc
    30361 caatgcccca aaacctataa atgctcctcc aaataaacct aatagaattg cgttttgtgt
    30421 cgaaatattt gcttttttaa tgcctgcact tatagttgct tgtgcagttt ccccaggtgt
    30481 caagaatcct ttactcataa atccttcccc cttaaaaatt atactttccc ttgtcttttt
    30541 atggcaataa ttatataata acaatatgat atataataaa ttttattaac ataaaaaata
    30601 tactatatac ttatatatac ttgtctcata taattatact atttattata taacaacttt
    30661 gttaatttcg aaataattta tattgaattt gaaaaattta ccttttgatt atttatttta
    30721 ctttttaatt attgaggtat tatatataat agatatatgt ttgtgttatt atatataatt
    30781 acttatttta ataaatattt gaaggaggga attttatgtt tgatatatca tttttcgaaa
    30841 tgtcaatata tgaaatagca gttactacaa tatatataat taatttcatg gttatactaa
    30901 accttatctt tagagaaaaa agaaacataa atacaacttt aacatggctt cttatattag
    30961 tattgattcc tgctcttgga ttcatacttt atatagcttt tggcagaaat atttcaaaaa
    31021 acaatatgtt tagattgaaa gaaaaggatg ataagataat caaaagtaat atactagata
    31081 ctcaggttaa actccaatct acatctgaaa ttgattcaga tatacatcaa cataaggata
    31141 tgatttatgc attggctaat tcaaataatg ctcattatac caataataac gatgtgtgga
    31201 tttatgctga atctagtcaa ttttttaaca gtcttcttga agaacttaaa aaagctaaaa
    31261 aatatataaa catacaattt tacattttca aagatgacaa aatcggaact gaaataatag
    31321 acattcttat agacaaagct aaagaaggtg ttgaagtaag acttttattt gatgcagttg
    31381 gtggtagaac actaaaaaat agtacacttt ccagacttaa agaaagtggt gttaaagttg
    31441 gaagcttctt cccatcattc ttgaaaattg taaactttaa cttaaactat agaaatcacc
    31501 gaaaaattgt tgtcattgat ggtaaggtag gatttgtagg tggatataat gttggtgatg
    31561 aatatttagg tagaaatcca aaatttggtc tatggagaga tacacatact aagcttactg
    31621 gtgattgcgt aattgaccta aatatgagat tcatccttga ttggagatat acaactaaag
    31681 aagacttaga tttagaaaag tactttatag aagaagatac aaattctaat catccttctg
    31741 aaaatattgg gattcagata gtatcaagtg gtccagatat atcagaactt gatgagatta
    31801 aatatggtta ccttaaaatg attcagaaag ctagaaagta tatatacata cagagtcctt
    31861 atttaatact tgactcaact tttatagata ctttaaaaat agcttgttta tctggtgttg
    31921 atgtgagagt tatgattcct tctaaacctg accatccctt tgtatactgg gcatcatatt
    31981 catatgctgg agaactttta aagtttggag ctaaaatcta tacttatggt caaaatgcat
    32041 ttttacatgc taagacaata gttatagatg actctatatg ctctatagga acagctaata
    32101 tggatatcag aagttttgag cttaatttcg aagttaatgc atttatgtac tcttcaaaaa
    32161 aagcattgga acaaagaatt atatttgaaa atgatatttt aaattctaag gaaataacat
    32221 tagatatata taattctagg tctacttata taaaaatcaa ggaatcaatt tcaagactat
    32281 tatcagcagt tttataaatc ttttatttta taaaaatttt acattttggt ttatttttta
    32341 aagtttttta tatgtattat ttttttttta ttgaatttag ctcatttttt ttattttttt
    32401 taactattct gaattatttt atattataat agactagtat agtttttatt tttaataggt
    32461 aacttttttg cattgttttt ataaataaag aaattgttgt atattattct ttctttattg
    32521 ttttggtttt gttcacccac ataatgttgg ggtcaactca tggttaatta ttttatgaaa
    32581 aataataact ttaaaaagaa aagggggatt tgttatgtgc gattttattt cacacaacaa
    32641 gcaattattt gacgaactag atatatttat tgactctctt gcaacaaagg aaggtgcgtt
    32701 aatacaagtt ctacatgaag cccaaggtat atttggatat cttccaaaag aagttcaact
    32761 tcatgttgct agaaaacttg gagtagctcc tgcaaaggta tatggggttg ttacattcta
    32821 ttcttatttt actacagaac ctgtaggtaa gtataaaatc agtgtctgtc taggaactgt
    32881 atgttttgta aaaggtgctg acaaaatctt aagtgctttt gaaaaacagc ttggcataaa
    32941 agttggagaa actactagtg attttaaatt ttctttagaa ggtttaagat gtttgggggc
    33001 atgtggttta gctccagttg ttactgtaaa tggtaaagtt tatggtaaag tgaaacctga
    33061 ccaagtaagc gaaatattag atacttatag agaattagaa ttgaattgtt aagaggggtg
    33121 aataaataat gcgtaaagta aattcatttg atgaattaaa agttttagct gatgagctga
    33181 aacctaatct tagcttaaga aaaaattatt ctaaggaaaa tgtattaaga agagaattac
    33241 ttgtttgttg tgatactgga tgtacatctt caaacagtct agaaatagtt agtgaattag
    33301 aaaatgaaat aaagaaatca ggaatccaag ataaagttag tgttcgtttg acaggttgtt
    33361 ttggtttctg tgctcaaggt cctattgtaa aagtttatcc tgataacgtt ttctacgtaa
    33421 aagttgagcc atctgatgct gaaaagatag ttcaaagcca cttaattaga aatacagttg
    33481 tcgaggaatt attatatgag gaagaatctt taagtaaaaa agttgaagaa caagaagaaa
    33541 tgtctttcta caaaaaacag ttacgtatag ctttaaaaaa ttgtggtctt atagacccag
    33601 atagtataga agaatatatt gccaatgatg gttatttagc tctaggcaaa tgtttaactt
    33661 ctcttactcc tcaagaagtt attgcagagg taaaaacttc tggccttcgt ggtagaggtg
    33721 gtgcaggttt ccctactggc tctaaatggg aagctgcttc aaaaaatcca gctggtccaa
    33781 cagataaaaa gtttgttgta tgtaatgctg atgaaggtga cccaggtgca tttatggata
    33841 gatctgtact tgaaggtgac cctcatagtg tactagaagc tatggcaata tgtggatacg
    33901 ctataggttc tgatacagga tacatataca taagagcaga atatccaaaa tctatagaaa
    33961 gattaaaagt agccatagct caagctgaaa aatacggttt acttggcgaa aatatcttag
    34021 gcactggatt taactttaaa ttagaattaa aatatggtgc aggtgctttc gtttgtggtg
    34081 aaggtacagc gctaatgcat tcaattgaag gtagacgtgg tgaacctaga atgaaaactt
    34141 atagttcttc taagagtggt ctatggaaat ctcctacttg cttaaataac gttgagactt
    34201 ttgctaacat acctgcaatt atacttaagg gtggagattg gtttgccaac ttaggtactg
    34261 aagattctag tggtactaaa gtctttgctc ttggtggaaa agtagaaaat gtaggacttg
    34321 ttgaagttcc aatgggtact actttaagag atattgtatt tgaaattggt gggggaatcc
    34381 ctgaaggtaa gaaatttaag gctgttcaaa caggtggacc atctggcgga tgtataccaa
    34441 ctgaacattt agacactcct atagactttg gttcattaag ttctatcggt tcaatgatgg
    34501 gctctggtgg tatgcttgtt cttgatgaat ctgactgtat ggtagatata gccaagttct
    34561 tccttgagtt tactgttgaa gaatcttgtg gtaaatgtac accttgtcgt ataggtacta
    34621 caagattatt agaaatatta actaaaatta cagaaggtaa tggtactcta caagatttag
    34681 atgacctaga aaaccttgct gaaactatac aaactgcttc attatgtggt cttggtaaag
    34741 ctgctccaaa ccctgtttta agtactcttc aatatttcaa agatgagtat atagctcatg
    34801 ttgtagataa gaaatgtcct gctggtaaat gtcagaactt actttcttac tttataacag
    34861 atgactgtaa gggttgtaca aaatgttcta gagtgtgtcc tgctggttgt ataacaggtt
    34921 ctgttaagga acaacataca atagatactt ctaagtgtct aaaatgtggt gcttgtatag
    34981 ataattgtac atttaacgct ataatcaaga aataacttat ttggaggagg aataacaatg
    35041 agtttagtta atttaactat taatggcaaa cacgtttcag cacctagtgg aacttctatc
    35101 ttagatgctg cgaaattaat aaatataaaa atacacaacc tttgtcattt acatatgaat
    35161 gaaatagata agcttgacac ttgtgcttct tgtcgtgttt gtatggttga gacagagaga
    35221 ggattagttc cagcttgtgg aacagttata aaggaaggta tgaaagttca gactaatagt
    35281 gctaaagcat taaatgctcg tagaactatt gttgaattat tgttatcaga ccatccacaa
    35341 gattgttttg tctgtgaaaa aaatggagat tgtgaattac agactatagc tgctgattta
    35401 ggagtaagaa aaataagata tcaaggttct aaatcttttg caggtaaaga tacttctact
    35461 aaatctttag ttaaagacca ttctaagtgt atattatgta gaagatgtga gactgtatgt
    35521 aatgacatac aaacagtagg agcattatct ggagttaatc gtggatttaa tactttagtt
    35581 agtacattct ttaactctga tatggttgaa acagagtgta cattctgtgg tcaatgtata
    35641 tctgtctgtc caactggagc attaacagaa gtagataatg tacctaaact ttgggatgtt
    35701 ttaaataaaa aagaaaagac tatagtagtg caagttgctc ctgctgtaag agttgctatt
    35761 ggtgaagagt ttggattaga accagggtca atctctacag ggaaaatggt agctgcttta
    35821 aaagcacttg gatttgaaca tgtatttgat acaaactttg gtgcagattt tactataatg
    35881 gaagaagcta ctgaatttat agaaagaatc caaaaaggtg aaaatcttcc tatattaaca
    35941 agttgttgtc ctgcatgggt aaacttctta gagcacaatt atccagacaa gttaaactta
    36001 gcatctagct gtaagtctcc tcaaggtatg tttggttcta tagctaaaaa ctactatgca
    36061 cctaaaatat taggaatcaa tcctgaagaa ctttatgttg tatctgtaat gccttgtgta
    36121 gctaaaaaat atgaagcttc aagagaagaa ttaagtgaat ctggaatact agatgttgac
    36181 ctttctataa ctactagaga gttagctaag atgataaaag aagctgcaat cgatttacct
    36241 aatcttcaag accaagattt tgataatcct ctaggaaaat ctacaggtgc tgcatctata
    36301 tttggagcaa gtggtggagt tttagaagct gccctacgta cttcatatga gaagataact
    36361 aataagactt tagataatgt aaacttcact aatgttagag gtcttaaagg aattagggaa
    36421 gcaagtatag atgttgatgg aactacagtt aatgtgtgta ttgtaaatac acttaaaaac
    36481 gctagaaaga ttatggataa ggtcagaagt ggagaatgta aataccatat catagaagtt
    36541 atggcatgtc ctggtggatg tgttggaggt gctggtcaac cttatcacca tggtaatact
    36601 gaaatagttg atagacgtgc aaatgcgtta tatgaaatag atagaaataa ggctattcgt
    36661 aaatctcatg agaatcctga tttacaagct atttataaag acttctttgg agaaccaaat
    36721 agtgatgtag cccataaata ccttcatact cattactttg ataagagttg tgtctatgga
    36781 gagtgtccac aagaatgtgc ttgtgaagaa gctaagtagt cataacaaaa tataaaattt
    36841 attcttaaaa aaggattgtc ttaaaatact tttacgtaat ttaagacaat ccttattaat
    36901 ttcacaaatt aaattatatt tctaaataga cttattcttt aattaaccta tctattaatt
    36961 aaagaatacc tgccattctc ataagttgtt ttgcatttgt agttttacat cttccatctt
    37021 ttatcttata gtcaaaatga attttatcgt ctacatagta ctctgagaaa tgatagttta
    37081 caacttcaac atctccacta cctgaaaggt cacatagctc aaagtcatgt gttgtcacca
    37141 tacttataac ccagggtttt gataatttct ttactgcctc acttgctcca ataattctat
    37201 cagcagagtt agttccctta aaaatttcat ctactagaac caacattggc agttctttta
    37261 aactatattg aatcattgat tttattctaa gaatctcagc atagaaagtt gatattcctt
    37321 gacttacatc atcttgtatt ctcatagaag taaatatagc catacaggtc gcatcaaaac
    37381 tcttagcgca tactggagca cctgcatatg ccagcactaa gtttacaccg atacttctta
    37441 aaaatgttgt ctttccagac atatttgaac ctgtgataat acaagtctga gaatttaatt
    37501 gtatcgaatt tgctatgaca cttttttctg ctattaatgg gtggtatacc tcttcaactt
    37561 tcaatcttgg agtatcttca tattttatta ctggaaaaca tgtattttcc tttacatgag
    37621 aaacaactgt taaacttatt agagcttcaa attctccaat agattcaaac caatctctaa
    37681 tttgatttcc atatatacct ttccatcgct ccaaagcttc tgcacaatga tagttccaca
    37741 tcaaaacacc acaggcaatt atatatagta tctgattata ccttaggttt acagcatttc
    37801 ctattgaatt taattgttta acacctcttg aaactccact tcccttagaa agtttatctt
    37861 gtaattcttt caaatatgca ctctcaaacg tctctttttc taaaacctca aacatttttt
    37921 catatacttg tatacttcta ctaaatgaaa ataatggagc aagagtttgc ataagtcttg
    37981 gatatccaaa accactaaac cctaactgga ttataaaaag taaaaaaaca ggtaaaacag
    38041 gtaaaaatcc taacatacaa aatataaaag ataagattgt tgcagttggt aaaccccaag
    38101 taaaaatatg catccatttt ggtatataca cattcttatt ttctccatat tctataaacg
    38161 attctatact actatctgaa ttgttttttt gctctttacc aattatatta ctgagtgttt
    38221 gaatatgaat agaaaaatca tcttttgata aaagttcttt tatagctctc tgtctttcta
    38281 agattacatt ctcatctgga ttttcattcc acaaatattt ggctaaaaaa tttttcccat
    38341 aagatgtatt agctacacag atatattgat acaatgatgc tcttccaaat aagtctaaat
    38401 cttttgcttg cgaattttca tcttttaagt attctttacc atctatttta aattccttcc
    38461 aaccatctcc aaatctctta atatacttat ttaatacttc gctcttactt ttaaaatatg
    38521 tttcttcttc ttttacttta ctatgaataa ctaagagtgc tataaatatt attattgata
    38581 aaactccaac aaaaatacct actatatttt tattgtaaaa tccaatagca aaccctgcta
    38641 tcactatcaa aaaagatatt aatcttgctg tacttatgtt atttgacttt ttacttaaga
    38701 gcaattcttt ttcagtacta ctttctaaaa gtttactaaa atattctatt cccataaaaa
    38761 attccaactt tcttgttata taatgaaact caaatataaa attaatctag tattattata
    38821 atctaacact gtactttaaa ttatccttat ataatatatc ttattaataa acattatata
    38881 tatacaactt gattttaatt tataaggtgt aggacataat cctaatcaat atttaattaa
    38941 atgatgtgta gttcactatt attcagtact acttagtatc gattaatttt gataattttt
    39001 tagtaaattc ttgagctgca tcgtatccca ttcctctttg tctaaaattc attgctgcta
    39061 cttctaatat catagcagta tttcttccag gtttaacagg tacaactaat ttctctacat
    39121 taacaccaag tatttcttca tattctttat ccagtcccag tctatcataa tacttagttt
    39181 catcccaagc ttctaaatga actactaaat ctatcatttt agaatttttg attgccccta
    39241 ctccatataa acttctaaca tctattattc ctattcctct tatctcaaga aaatgtctta
    39301 ttagttcagg tgactgaccc acaagcatac tttcatctaa ttttcttatt tctacagcat
    39361 catctgcaac taatctatta cccctttgaa tcaattctaa tgctgtttcc gactttccta
    39421 tactactttc accttttatc agtacaccta taccataaat atctactagc accccgtgaa
    39481 ttgttgtgtg tggtgctaac ttattatcca aatagtttga cagtctattt ataagtctag
    39541 tggtatttct atttgtgctc aaaagtattc ttttatattt tttagccttt tcaattacat
    39601 ctggcttgat ttccaagtct ctagaaatta ttaacgctgg tatttcatat gagaaaaatc
    39661 tatctagtac ttcttcccga atatgactat ccattaatcc aaaaaaatta tattctgtct
    39721 ttccaactat ttgtattctt tcatatgcaa aataatcaaa atatcctgca aactgtaatc
    39781 ctggtctatt tatatcttga gagtagacat aataatctac atcatcaggc atgtatacta
    39841 cttttaactt caactctttt attatctctc ttattgatac tttattgcta gtttccatta
    39901 attttcttcc tttctaaaaa aattataaac attatctgca atgcttttat tcattccatc
    39961 tacttctaaa agttcttcca tagtagcttt ttttatagca tctacatctt taaagtgatt
    40021 taataatgat ttctttcttt tttcacctat tccttgtata tcatctaaga tagattttgt
    40081 caaagcttta tttcttagac ttctatgata tgttattgca taattatgaa cttcttcttg
    40141 tatactagca ataaatctat ataaattagt tgttttatct agttctattt ctttttcttt
    40201 gcatatcaat cctttagttc tatgcttatc atctttgtac attccccaaa gaggtatatc
    40261 tacatcattg agttctagta ctttttttac tgcactaact tgtccttttc caccatccaa
    40321 caatatcaag tcaggtaaat ttccatgttt taatcttcta tctacaattt cagccataga
    40381 atcataatca ttaggtccaa taactgtctt tattttatat ctcctatatt ccttcttatc
    40441 ttttttagca ttcgtataca ctaccataga accaatcgaa tctacacctt gtatatttga
    40501 tatatcataa gcctctattc ttattggcaa cttttctaga tttaatattt gctttaattc
    40561 ttccaatgct ccaatacttt tttcatattt tcttttattc atatcagaaa atttttcaag
    40621 atattctaca gcatttttcc taaccatttc aactaagctt ttcttctctc ccttttgagg
    40681 aactcttatt gttacttttt gccccttttt agatgacagc cattcttcta atatagaact
    40741 atcttctatc tcatcttcta taattaattc tttaggtata tactcttgtt cattataaaa
    40801 ttgttttaca aatgaactta atatagaagc tcttggacta tccattaccc cttctaatat
    40861 aaaatgttcc ctacctacaa tcttaccatt tcttataaaa aatacctgga cacaagcttc
    40921 attatgagct cttgccattg caaccacatc ttggtttaag tcacttacag tagcatctat
    40981 tttttgtttc tgtatcatct cttcaaggct ctttatctta tccctatata cagcagcctc
    41041 ttcaaatcta aagttcatag aactctcatt cattttttcc tttaaaagtt ccatcaattt
    41101 ttcttcttta ccagataaac acattataat ctcttctatc atttttccat actcttcttt
    41161 agaaacattt cctgtacaag gtcctaaaca tttatttatg tgtagattta aacaaggtct
    41221 tgtcttattc tttattgctt tatctatatc tattttacag cttcttattg gatacgtact
    41281 acttataagc tccaaggtat cattcacagc agttatattg gtatagggcc caaaatactt
    41341 tgccttatct ttaagaactc ttctaacttt taagattctt ggataatctt cattcgtagt
    41401 tacttttata tatggataag ttttatcatc tctaagcact acattatact ttggtctgta
    41461 tctttttatt aaattacatt caagtattaa tgcctctaac tctgaatccg ttataatata
    41521 ctcaaactta tatatattct taaccataga ttttacttta gatgtatggt tttttgaaga
    41581 ttgaaaatac tgccttaccc tattttttag agatatggct tttcccacat atattatatg
    41641 gtcgtatttg tctttcatta aatatactcc gggctcagaa ggtaattttt ttaaatgctc
    41701 ttgtatatca aacatctcgc cctccaaaac attaaatttt atactaaaat tataccctaa
    41761 aatatgaatt ttaaaaagtt atacaatttc cagtgcttta aacaagttaa agcccatatt
    41821 cccttctata attgatttga aaacaatttt aaccatgaag agtaatatgg actttacttt
    41881 gtattactat ttacaactta tatttgacta atttacttat aacaaaacag tttatcgtat
    41941 atctgctcta aaatttttca caatttatat aacttaagaa aaatatttct ttaagaattg
    42001 acctgtataa gaaccatcaa ctttagatac ttcttttggt gttccagttg caactatagt
    42061 tccaccctta tctccgcctt ctggtcctaa gtctattaca taatcacaag tctttataac
    42121 atctaaatta tgttctatga ctataattgt atttcctgta tctgctagtc tttgtaatac
    42181 ttggattagc ttgtctacat ctgccatatg aagtccagta gtaggttcat ctaatatata
    42241 caaagtcttt cctgttggtc ttttactaag ttcagcagct aattttatac gttgtgcttc
    42301 tcctcctgat aattgagttg aaggctgtcc taatttaata tatgaaagtc ctacatccat
    42361 taaagtttct aattttcttt ttatatttgg tatattttcg aaaaactcaa cagcttcttc
    42421 cacattcata tctaatatat cagatatagt tttatctttg tattttactt gcaatgtttc
    42481 tctattgtat ctttcacctt tacaaatttc acaaggaaca tatacatctg gtaagaaatg
    42541 catttctatt tttattattc catcaccctt acaagcttca catctaccac cttttacatt
    42601 aaaactaaat ctaccttttt tataacctct tgctttagct tcattagtag atgcaaaaat
    42661 atctcttata aaatcaaata cacctgtata agtagcagga tttgaacgag gtgttcttcc
    42721 aataggactt tggtctatat ttataacttt atctatactt tcaattcctt ttatctcctt
    42781 atgcttacca gctctttgct taagtctatt cactttactt gcaacacctt tgtaaagtat
    42841 atcgtttatt aatgtacttt ttccagaacc tgaaacacct gttatgcatg taaacttacc
    42901 taatgggaac tttacatcaa tatttttcag attattttct gatgctttaa ctatttctat
    42961 aaaacttcca tttccttctc tagtagtctc aggaagcaat atttgttttt taccacttaa
    43021 atattgaccc gttattgagt tctcattttc aattatttca tctaaagtac cctgtgcaac
    43081 tatttcacca ccatgtatac ctgcacctgg accaatgtct ataacataat cagcttctct
    43141 cattgtgtct tcatcatgct ctacaacgat taaggtattt cctaaatctg ttagatgtct
    43201 aagagtagtt ataagcctat cattatctct ttggtgaagc cctatacttg gctcatcaag
    43261 tacatataaa actccaacca atgcagaacc tatttgagta gctaatctta tacgttgcgc
    43321 ttctcctcct gataaagttc cagcttttct tgataaattt aaataatcaa gacctacatc
    43381 tcttaagaac atagctcttc cttttatctc ttttataatc tcatgagcta taaatctctg
    43441 tttttctgta agatttatat tttccataaa gtcaatcaat tcatttacag ataagtttgt
    43501 aacttccatt atattttttc catcaactaa aacagataaa acttcctttt taagtctcat
    43561 ccctttacac tttggacatg gtctctctgc catgtattct tcaatcttat ctctcatgta
    43621 atctgaatta gtttctctat atcttctctc taagtttact attacacctt caaagtatga
    43681 tttataattt ctagttcctc caaattttga ctcataagta aactctacaa ttatattatc
    43741 tttaccataa agtaattcct ccacaaaatc atctggtaaa tctttaaacg gtgttgtcaa
    43801 agatacatta aaatgctctg ctaaactttt tatcatttta ctgtaataag tgtcatcatt
    43861 aacacctgtt gaaccccatg ctgccactgc accttgtttt attgataaat ctttgtttgg
    43921 tactactaat tctgggtcaa cttctttact ttccccaaga ccattacaaa catcacaagc
    43981 accaaaggga gcattaaatg aaaacattct tggagataat tcttctatgc caattccatg
    44041 ttctgggcat gcaaatttag ttgaaaaaag aatttcttct ccatctatta tttgggctat
    44101 tacaagacca tcagatagct taactgcagt ttcaattgaa tctgctagtc ttgattctat
    44161 tccatcttta attactattc tgtccactac aacttctata ttatgttttt gatttttatt
    44221 taagattata tcatcactaa cttcatagtt ttcaccatta actctaactc ttacaaatcc
    44281 ttcttttttg atattatcaa agactttttt atgtgtacct ttttgtcctc taacaattgg
    44341 tgaaagaatt tgtaatttcg ttctatctgg aaaatctagc attttatcaa ctatttcttg
    44401 aatagtcatc tgacttattt tttcaccaca tgtagggcaa tacacatctc ctactcttgc
    44461 aaataatagt ctcaaataat catatatttc tgttactgtt ccaaccgtag aacgtgggtt
    44521 ttttgaggta gtcttctggt caattgagat agctggtgat aaaccctcta tatattctac
    44581 atttggcttt tccatctgac ctaaaaattg tcttgcataa gcagatagac tttctacata
    44641 tcttctctgt ccttctgcat atattgtatc aaatgccaaa gaagacttcc cagaccctga
    44701 caaacctgta aaaacaataa atttatctct tggtaattct aaatctatat tttttaaatt
    44761 atgttctttt gctcctctta ttataatttt atcttccata atgttgtttt tacctttcta
    44821 tttttccaat ttttcttcta attgtttcac tttatctcta agttctgctg ctctttcaaa
    44881 ttgtaagttt tgagcagctt ccatcatctc tgattttaat ttatctatat tagctcttat
    44941 ttcgtcttta tcatctgtat cagatattcc atatacaact tcttcctctg caaccttagt
    45001 agcttctata ctatctctta tatttttctg tatagtttta ggaatgatat tgtgctcttc
    45061 attatataaa ttttgtatat ctcttcttct ctttgtttca tcaatagcat tttgcattga
    45121 gtcagttatc ctgtctgcat acataattac tcttccattt tcatttctag ctgcacgtcc
    45181 aatagtctgt attaaagctg tttcggaacg taagaaacct tctttgtctg catctaaaat
    45241 tgctataagt gaaacttctg gtatatccaa tccttctcta agtaagttta ttcctacaag
    45301 gacatcaaac ttccctaatc ttaaatctct tattatttct gttctttcta atgtaactat
    45361 atctgagtgt aaatatttaa cttttatccc tatttcttta agatagttag tcaagtcctc
    45421 actcattttt ttagttaaag tggttataag cactctttca tttttttcta tagttttagt
    45481 tatttctcct accaaatcat ctatttgatt atttataggt cttacttcta caattgggtc
    45541 taaaaggcca gttggtctta ttatctgttc tgctattgtc tctgagtgtt gaatttcata
    45601 aggccctggt gtagcactta caaacaacat ttgatttata tttccttcaa attcttgaaa
    45661 atttaatggt ctattgtcaa gtgcagaagg taatctaaaa ccattctcta taagtgatgt
    45721 ttttctagac ctgtctcctg catacatacc tcttacttgt ggtatagtga catgtgcctc
    45781 atctacaatt atcaaataat catctgggaa gaaatccatt aaagtatatg gtctttctcc
    45841 ttctgacctt cctgtaatat gtctagaata gttctctatc ccctgacaaa atcctatttc
    45901 ctttaacatt tctatatcat acttagttct ttgttcaatt ctttgtgctt ctaatagcct
    45961 atcattttcc ttgaaaaatt taatttgttc ttgaagctcg ttttctattt ctacaattgc
    46021 cttttcaatt ctttctggcg ttgttacata gtgagatgct gggaatataa caacatgatt
    46081 tctagtacca acaatcttcc ctgttacata atcaatttct gttattctat ctacctcatc
    46141 accaaaaaat tctattctta ttgctttttc atcattacta gctgggaata tttctagtat
    46201 atctcctcta actctaaagg tacctcgtgt aaagtttatg tcatttcttt cgtattgtat
    46261 ctctattaac ctttttatta catcatctct gtctctttgc atacctggtc ttatagataa
    46321 cataagttct ttatagtctt ttgggtcacc aagtccatat atacaagata cagatgatat
    46381 tattatagta tctcttctct ctaaaataga tgctgtagca gaatgtcgaa gtttatctat
    46441 ttcatcattt atgcttgcat ctttttctat ataagtgtca ctgtgagcta catatgcttc
    46501 tggttgataa taatcatagt aacttacaaa gtattcaact gcattgtctg ggaaaaattc
    46561 tttaaactca ctgtaaagtt gtgctgctag agttttatta tgagccatta ttagggtagg
    46621 tttcttaact tgttgaatga tatttgccat tgtgaatgtt tttcctgaac ccgttacacc
    46681 taataatgtc gaaaatttct catttctatt tatagaatcc actattgatt taatagcttc
    46741 tggttggtca cctgtaggtt tgaagtctga ttttatttta aaatccatag tatcactcct
    46801 tttttcgaac attagttcct gacatgtatt attatatcat acctttataa aattgtttaa
    46861 gttattttaa atattttacc catttaaatt ttacttaaat ctaaaacata aaaaaagact
    46921 tctatctttg caatagaagt ctataattca tggaaaataa atactttatt caacttacat
    46981 aataaaatca aatgcttctt tttcaactcc atctaatttt aaattaaaca tttttaatat
    47041 agttgctgca tgtgctctca ggtctccttc ttctataacc acaccacctt taatatttgg
    47101 tccaaaagct ataaatggag gtctattacc tttagtaggt aaatgaccat gtgtcgcaac
    47161 agcaaacttg taatctttta tatctgaatc ttttataata cttccttcga aatcatttcc
    47221 aaatgaaatt ccttcaagac cttcaattac catttcaaaa tcaccttcaa gaccaaggtt
    47281 agatgcttcc tctttggtaa aaatattctc tatgaataat tcttctttaa attcttcaag
    47341 cagttctctt aattctgtta acctatctaa gttatttact attatttgag ctgatattcc
    47401 agaagaattt acataggcat caaaatcctt aacttctcca ttttcaactt ttataaatcc
    47461 atttgattta agcaagacat ttggatttat aactttatca actctaagat gaccatggtc
    47521 cccaagtatt ataaaatttg tatctttgta tgtacctgca tcctttgtag cctgaataat
    47581 atctcctaac catttatcat tcatttttaa tgctttatct acttcgtcat taaataagcc
    47641 ataattgtgt cgtgtatggt ccaatgtagc taaatgtatt agcattaaat ctggtttata
    47701 ttcctttatt atatctactg aacagtttac tccaaataaa tccatgttgg gttctaattt
    47761 ccaatcgata taatgacaat gtctattgta aataccgtcc attataacct tactggaact
    47821 tcgttcaaaa gtttctcttg ggtcatcttc tctactagga gcccatattt ctgcaatatt
    47881 ataatctata tttggatttg ctcccattac aggccataat acactagagg tagttagatt
    47941 attttctttt gctacatcta taatagtttt tgcttttatg tcctttgagt accagtacca
    48001 gtctttattt tctttatttg ggtcaaattt ttcattatga tatataccat gttttttagg
    48061 atatactcct gtaaccatac tagtatgaca cggatatgtc agagtgggat aaacacaatt
    48121 tatatttttt actatggagc agttttctag tatagattta aagtttggta gattttttac
    48181 aaattccaag tctttttcaa ataaagaatc tactgataat actataacct ttgtcattta
    48241 cattacctct tcatttatat attattgaat acttttaatc aacttacaag tctatataat
    48301 tatttatttg ttttatctat tactgcttgc attgcagaag ttcctttgct tactacatct
    48361 tttggatttg catttaaatc agtaagcccc tttttaatct catccattag cttatcagtt
    48421 gcttccttgt atccatttaa cattggaagt gcaacagcat attgtaattg gtcagttgca
    48481 accttatatt gaggtttttc tttatataat gtttgtaact tttctgagtt tgttgcatct
    48541 tcagttgttg gtaagtatcc tgttgatgaa ctaaactgaa cgattttatc tgtttgtgtc
    48601 atccattcta taaattctgc acttgcttct ttttctttat ctgttccacc ttcaagcata
    48661 actagattag ctccacctgt aggagttgcg tatttttgat tttttggtaa gaatgctgtt
    48721 gatatttcaa acttaccttc tgtttgttgc ataagtcctg ctaaatctgc tgttgatgta
    48781 aatatcatac ctactttacc atttacaaaa tcttgttttg ctacgtccca ggcattataa
    48841 tcttctccag gaggcatttt cattattcca gctttcatca tatcttgcca gaacttaact
    48901 ggtgcttgtc ctgcctcatt attaaatgct acttttttac cattagttat ttctcctcca
    48961 ctttgcatta ccatagcttc atagaaccaa atatctattg gtgtttcaaa accataagta
    49021 tcttctgatt tatttgtcat tttactagca taatccttaa gctcttccca tgattttgga
    49081 cctgaagggt caagacctgc tttagttgcc atatctttat ttatgtataa tattggtgta
    49141 cttctattaa atggcatacc aacaaactta tcctcataat atgaatttgt taaaagacca
    49201 gaaaagaatc tttcttgata tgttttatca aaatatttac tcatatctac taaagcacct
    49261 gctgatgcga atgtacctgt ttgagttatt tctaataatg ttacatctgg ttggtcttta
    49321 gatgttaagg ctgcctgtag ttttgttgca ttttcatagt aatctttctg ttttaacata
    49381 tttacttgta catccttatg ttcactatta aattggtcaa ccattttttg agcagtttct
    49441 ccattagttc cacctaaagg agcccagaaa tctatcttcg taatattgct atcagtcttt
    49501 tctcctttag atgcatttgc atcattagaa tttgaacacc caactaaaga acctaataat
    49561 aatgttattg ctaatcctgt tgctaatttt cttttaagct tcattttcat cctccaaatt
    49621 tagtctttaa ttttttattt tattcctgaa tacataaaag cttcttttac ttttttattc
    49681 gcaaatatat aaacaagaat tattggtaaa attagaatta tatttcctgc cattattaca
    49741 ttccatgcag taattccttc tgaagattta aggagcgcaa ctcctattgg taaagttctt
    49801 attgcatctg tatttgtcat tactaagggc cagaaataat tattccaatg gtatataaaa
    49861 ttaaataata taaatgttat tactgctggt tttgccatag gaaccattat tctaaacatt
    49921 atttttaagt cagaagcatt atctagttta gctgcttcaa taatttcatc tgaaatctgc
    49981 ataaaattct gtctaagcag aaatatccca aatgaagatg tcataaatgg aattataagt
    50041 ggaacataag tatttataaa tccaaactta ctcatcatca tatagactgg tagaaaagtt
    50101 acttgtggtg gaatcataag tcctacaagc aaaagcccaa atagcatttt ttcaccttta
    50161 aatttaatct tagaaaatgc atatgctgct ggaaccataa ctaaaaattg tacaattaaa
    50221 acacttcctg ttacaaatac actgtttagc aaatatctaa aaaatggacc tgaatgccat
    50281 gctgtactat aattttctaa cactatatca tttggtataa tagtgggcgg taattgcatc
    50341 atttcttgtg gatttttaaa ggatgtagat agcatccata taaaagggaa tataaatatt
    50401 gcagataaaa gtaatagaat taatatttct attgattttg atgctatttt ttttatatca
    50461 actttgtctt ttttgatagg ttgtataata tccattgtct cctccttttg gataaacctt
    50521 ataatatcta ctttttcttt attgataatg aactttcttt gataagagtc taaagttagc
    50581 atatgtagca atcataacta tagctaacaa aaacatactc gctgcactcg cttgccctat
    50641 gtcatagtat ataaatccag actcatatat ataataagat aacatgttag ttgaacccac
    50701 tggcccacct tgtgtcatta tacttatctc atcaaatact tgaaaagatg cagttgttgt
    50761 tgttatcata agaaaaaata ttgttggtga taatagtggc aatgtcactt taaagaaatt
    50821 cgttattttg tttgcattat ctaatttaga tgcttcatat atatagtttg gtatggattt
    50881 aagacctgat aacactatta agatattata tccaagagtc ttccatattc ctattagaat
    50941 tagtgacatt aaagctgaac tttcacttga aagccacttt gatgttggta aatgtaatgt
    51001 cgatagtatc cagtttaaaa agccatattg tggctccata atccaaagcc acaatacagc
    51061 tacagatact agtgaaatta catgtggtgt aaagattata ctttgcgtta aattgtgtat
    51121 tatagaattt ttatttagcc aaacagcaag tactatggct agtgatatag atatagtcac
    51181 cataaaaaaa gtataaattg cagtgtttgt tatagtttgt ataaactctg gattctttaa
    51241 aagttctgta taattgttta agcctacatt ttcaaaggtt gaactaagaa gactaccaga
    51301 tttgaagctt agagatatcg tcttaattat tggatagact ataaacaata aagttcctat
    51361 aatagcaggt gttatatata aatatgcttt attaaattgc tttttcataa atatctcctt
    51421 taattttaga atacatactt ttacatactt ttacatcttc tattctttct ccatttttat
    51481 caaaataata taaatctttt tctaatacac ttattcttaa agttcttcca atatcaaata
    51541 tatcattttc tgttttgact cttatctctc tattaagaac agataaacaa tatatagttt
    51601 catttcccaa cacttcttta gttacaactt ttccaaatag actaaataca tcatcatttt
    51661 ttccatctat gtttatactc tctagtgttg ctttttctgg tctgaatcca aatttaatat
    51721 cattttttat atctagtatg ttcatacaag gactccctat aaattgagct acaaataaat
    51781 ttttaggatt ttgatatatc ttctttggag aacctatttg cattatcttt cctttgttca
    51841 ttataactat cttatctgcc attgacattg cctcaacctg gtcatgagtt acataaacaa
    51901 atgtagactt tagtttttga tgtaattgta ttaattctgt tctcatttga tttcttaatt
    51961 tagcatctaa atttgacaat ggttcatcca ttaaaaatac ctttggattt ttaaccatag
    52021 ctctagcaag tgccactctt tgtctttgac ctccagataa gttgcctggt ttcacattta
    52081 aatattctct caatcctact acatcaataa cttctgttat aagtttttct cttttttctt
    52141 tttctacttt tttgttttta agaccaaatt ctatgttttc tctaacagtc atatgtggat
    52201 ataatgcata attttgaaat accatagcta tatccctttt actagcatcc gtttttgtaa
    52261 catcattttc ttcaatcttc aacctacctg aagttatatc ttcaagacct gcaatcattc
    52321 ttaacgtagt agatttacca catccacttg ggcctaccaa tactgtaaaa gaaccatctt
    52381 ctatagtaag atttaaattt tctataactg tatttttttt attataagat tttgttacat
    52441 tttctagtct tatatctgcc atttttatcc tcccaaaata tttaatttaa ttctacgatt
    52501 tacttataga ttaataatac tcttaatttg taaaggatat attaagacaa agtgaatata
    52561 tggtaaactt attaaaataa aggttaaatt ataaacattt tttgttaaat atactgaggt
    52621 taagatgata tacagcttat gttagctata attttctata tttttcatat tcattgtttg
    52681 ctatcacaat gtaattttaa tttatgaaga gtcatataaa actatttatt ttttatataa
    52741 tttgatttga aagtaaaaaa gacctctatg ggggatagag gtctttaagt gggggagatt
    52801 gagtaattta tttttgctat attaagtttt acaattatat tatgtcccaa atttacaagg
    52861 tttaaacata aaaaataaaa attttttaat ttttataaat ttacccaaaa aaaattacgt
    52921 ggctacgtcc tactctccca ggcagtttcc caccaagtac catcagcgct agagagctta
    52981 acttctgtgt tcggaatggg aacaggtgta tcctctctgc tattgtaacc acataatctt
    53041 tatgcttaat atttctatta agtttttaat aagtttatag aacctag
//
LOCUS       DAEPID010000021        52768 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.021, whole genome shotgun sequence.
ACCESSION   DAEPID010000021 DAEPID010000000
VERSION     DAEPID010000021.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 52768)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 52768)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..52768
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.021"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            289..2301
                     /locus_tag="KR257_001369"
     CDS             289..2301
                     /locus_tag="KR257_001369"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892871.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="N-acetylmuramoyl-L-alanine amidase"
                     /protein_id="HBH0030081.1"
                     /translation="MRRNTKLLTTGILSMAIVAPTMAFATESNAMENNADLNINLEKK
                     SIVLGSKSKVSVKFKEKPDADSITLKYKCYDMPLDTTLNYNQSTGAYEGTINYNQDPE
                     YLNVWELQGITINSKNNPKTLNRQDLEKLGLNLKDYNVTQECIIEDITSRKDVNKYLR
                     KTSSPITELTGSDRYETAVKISKEGWKNGSDKVVIINGDVSIDGIISTPLATTYNAPI
                     LLVEKNNVPNSVKSELKRLNPKDIIIIGDENAISKTTANQIKSTVNASQTRLNGSNRY
                     ETSLLIAKEIDKNHDVEKIYITNANGGEVDALTIAAKAGQDKQPIILTDKDSITDNTY
                     KWLKSEDLQNAYFIGGPQMISTNVINKVNGITKDSVTNNRVYGADRHETNANVIKKFY
                     TDDELEAVLVAKSDVLVDALAAGPLAANLKSPILITPKTYVSAYHKDNLEAKSANKVY
                     KIGGGLTSKVMSSIASSLSKHNTTPTEPGNSGGKTVMIDPGHGGSAPGNSSGGMIEKD
                     YNLNTSLATTEYLRSKGFNVIMTRDTDKTLSLGNRTALSNSLKPDLFTSIHYNGSTNK
                     QGHGVEVFYKLKDKNGGTTKTVATNILNRILEKFKLTNRGIKTRVLPSDSTKDYLYVL
                     RSNDMPAVLVECAFLDNENDMSLINSSAKVKEMGTQIGKGIEDSLK"
     gene            2543..4456
                     /locus_tag="KR257_001370"
     CDS             2543..4456
                     /locus_tag="KR257_001370"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729491.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0030082.1"
                     /translation="MEYLFEKSSLKEYGNEALDKYRELLDKTGNNSRCILLLVPNNNT
                     KIRYERALRLNYSEELKVTTYISFVKKELVKYWPLIIEKCDGISTKVVSPTFISNSLS
                     EYLIVQKVKEKRIQEGYFEDITGTNKSIANSIMTNINKSAFNLIDFDFIGEKIYSSKK
                     NKDSIYRFSYTQMDEIISYYINSLLSNSILDNALSIYLYNQYLLNDDFYLKNLFTEVR
                     YIIVDSLESSSNAEVDFITEALDNTLQSYIYFDYSRDYSVFNNVDIDYINEKIISKIK
                     PKEENIKKKEIRIEDLYLLPANIELNQSSQLYNEMLDLISEKVISLIEEDVSPRDIAI
                     ISPINNSILEHQIRDSLIEKNIDVFSTKKDKKAVDYPYGNALVVATCIFYGYLDFIKD
                     DEYLSFLETLLEINRIKAFKIFNETRHLSIDNIDEHSQYRDILQYIEEKKKSDIKIHE
                     FLTQFYIDKMLNLKEGKKNVGLCKKIIAESESFSESLSLLGMKKEKIFVEALKSTIND
                     YYSVVDIEELKSKDKIVITTPYSYISSNIDRSIQIWVDIGSNAWNMKIEKDISNLIVL
                     RKSFEEKKIYTNEMEEYYKKYYLYNTVYNLLLNAKKIYAFKSEYAINGYIQESILYSI
                     LLKISHKGDKNYD"
     gene            4449..6668
                     /locus_tag="KR257_001371"
     CDS             4449..6668
                     /locus_tag="KR257_001371"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428591.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-dependent helicase"
                     /protein_id="HBH0030083.1"
                     /translation="MININYREDQIPIINYDNGTMAVPAVPGAGKTFIITNLVAKLLL
                     EQKHKSGKILILTYMNSAVNNFKGRIRKILEENKIDDTNSYEVMTIHSLAVKIIKEKP
                     EVVMLSEDFNIADDLQKSIILNECISRFRFEGGERAFRWFLKEQKDERWKEITLEAWE
                     RGFFEFAGNAISELKYKGISPDKLEEILSRGHKGILKIILPIYKLYDRKLKQNGLLDY
                     DDILILAEKTLSLDEGLRKKFQTRYKYIFEDECQDSNEIQGNIIKIISSENKNLVRVG
                     DINQSITGTFSSSDPKFFKEFINSADFCYRMDMSNRSSKDILDLANTLVKYVTKEFRQ
                     EECRHALEDMQIKTVPNGMGYKENPNPEHYNINVKWYESWKIEIEQTARYVKGIKNKY
                     PDKSIGILVPFNEQVTQVAKELRENNLTFEELGPNSLNKRKVINNIAYIIDFMLHCDD
                     VEKLIVVLNKVFIDTDNEEEIKYFLEELKNYSTEEIIYNFEFSKLDNDLIEFKEESDI
                     YLSFKRGIDIIKQILEYPIIRLDLLVLFIGKKLSLEKEDKAVLDYISFYIKYLVSENI
                     NMDLEDVYNLLFDVKNRVFNHIIDVVYEINGYEPEPGSITLCNYHKSKGMEWDCVFLL
                     GLVEYNFPDNINQKFQSDKWYLKEKYKNPMAIIKSEVEAILKGSISTDYAHKTKIDSI
                     NEKIRLLYVGITRAKEMLVLSGSAYRDESDIGNKRKEQKPCIYLSRLNQHIIEKRSN"
     gene            6777..7607
                     /locus_tag="KR257_001372"
     CDS             6777..7607
                     /locus_tag="KR257_001372"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418847.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PD-(D/E)XK nuclease family protein"
                     /protein_id="HBH0030084.1"
                     /translation="MNDKLKYFSYSQNSINTYKSCPLKFKYKYIDRINWKNDDVGSRE
                     YYETLKTGRDFHLICERYFSNIPLGIYFNEDDKNSKKFLKWMENIKKVVPIEKGKTYL
                     PEYEVRMTLNGDIIQAKYDLVVIGNNNIEIWDWKTESKKIDYKHVENRIQTIVYMFLA
                     KEVIPKVLKMDINVKDINMRYYQPEFDDLPITILYDEEKHEANRNKIQNYISMIKNTN
                     YEEHTYEDNLYNDIEKVYNKEERMCYRNKKHCKYCEFNKLCNGKEIDYSILEAEIYGT
                     "
     gene            7597..11064
                     /gene="addB"
                     /locus_tag="KR257_001373"
     CDS             7597..11064
                     /gene="addB"
                     /locus_tag="KR257_001373"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861078.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helicase-exonuclease AddAB subunit AddB"
                     /protein_id="HBH0030085.1"
                     /translation="MGLRFVLGRSGSGKSTYILDEIKKEAQKNETTSIILLVPEQYTF
                     EAENRVSKLFLGKEKDKYLRVRVLSFKTLSNIVFSQVGGLTDVNINSSGKAMMVYRAI
                     EDVSEELNVFSKSKSQSGFVSSITDMISEMKQYNISPEMLENISGELDNETLSLKLKD
                     ISKIYNSFEGKLHENYVDAQDMLTSLASKIELSSYLDGACVYIDEFTGFTPNQYNVIK
                     SILNKSKSVNISLTVDDINYIGYSKSDMFSRTKFTYSKLTQLCNEEGIKILPQVNLNT
                     GVIKRFEKVKELQHLERFYNAYPYKIYSNQTENIKIKEFNNLYSEVEEIAREIVHLVR
                     DKNVRYRDITIATRDLNRYDFLVHSIFNEYNIPNFIDKKREAKSNPIVILIISALEMK
                     NRRYGYETMFRYLKSGLIGIDNDDINLLENYVLANGIKGKKWFDEKWDYRITQSLSGQ
                     ESEFELELKEKINEIKNRVLEPIVILQEKLRGKNRVKEICRYIYEFLLDINMPETIES
                     LIINFKDKGELDVANQYSQVWDIVVDILDQMVELMGDEIISLEKFIKLITLGFDEYEL
                     GLVPPSIDQVLVSSVDRMKNPDTKYLYLVGTTDGVFPLITKDSGILSDNDRESLGNKG
                     IEVDIDSKTRSFEEQFLVYKALTSTSKNLTITYPISDHEGKTLRPSIIISRLKKIFPN
                     IENKSYLVEENKSTDKDILKKITVKSPTFNELINVIKNYDSDGYNTEEINSIWLDIYR
                     YYLKDEIYSSITKKVIKGLSYTNQVHKIEEKKIRSLYKSNSLSISRLEKYAECPFAYF
                     IQYGLKAKKRKEYSFTPPDLGTFIHNILDRFSKELLQDNLTWRDIDEKYIELKIGIIV
                     DEIILKIPGYILNSSERYKYLAYRLKNMLTTAITIISQQIKQGSFEPIDYEVKFGNNG
                     KYPPIKMVLENGQEVSLIGQIDRVDEFEEGENKYIRIIDYKSGNKSISLTEIYYGLQL
                     QLLVYLDAILESAKDEDININPAAILYCRINNPIAKFNEDKDDEEIQEAILKELRMKG
                     LVVKDSHIVKEMDKSLIDGERKNSLVIPVGLTKDGNVGKSTSAISYEDFKLLRKYVRH
                     AIKDLCEEMLSGEIRIAPYKHKDGTSCDFCDYSAICQFDSTIKDNKYKNLNNKSNEEI
                     IKMMKGDVN"
     gene            11064..14891
                     /gene="addA"
                     /locus_tag="KR257_001374"
     CDS             11064..14891
                     /gene="addA"
                     /locus_tag="KR257_001374"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896009.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helicase-exonuclease AddAB subunit AddA"
                     /protein_id="HBH0030086.1"
                     /translation="MSSPKWTKEQLEVIESRECNLLVAAAAGSGKTAVLVERIIQMIT
                     SRENPIDIDKLLVVTFTNAAASEMRERIGDAIGKALDENPENKHLQNQLVLLNKSSIT
                     TIHSFCLDVIKSNFHRINLDPNFRIGDQTECAILKQEAIEEVFEDLYEERDEGFLNLV
                     ESYAERGGDKEVQDIILGIYSFAMASPEPKKWLIDSAERFNIDENFDFSQSIWARAIL
                     DTVKIEINGLCLNMERALKEVESIEELETFAEKLSVEYKKIADISQACNKSWDEAYKK
                     MASMSFENYVKGVKRISKDAPSYIKESKEKAKTIRDKTKKSLESIVSATFNKDNDSIR
                     EEIKYLYNIVKPISSVVLRFEEEYSNKKREKGIIDFNDIEHFALNILTDVDEKGNIVP
                     SDIAVGYRNKFYEIFIDEYQDSNLVQEVLLKAVANTETPNRFMVGDVKQSIYRFRQAK
                     PELFLQKYNNYNDKKGSSHRKIMLYKNFRSREEVVDAVNYIFENIMNENIGEIEYTEK
                     ERLNLGANFNVDTDEKSIIGGATEIHLIQKDNKLDDDIINDKDDRINNKENEIEEEEK
                     LDNIQLEARMVGNIIKDLMKVNEDGKIQKVYDKGIDGYRPVEFRDIVILLRATSAWAP
                     VFADELMNMDIPTYADVGVGYFDTIEIKTILSLLQIIDNPMQDIPLISVLKSPIFGFT
                     PEDLIDIRVQSKDKIFYEVLKSTAEYDGFTDSQNENESEFIPSEECINKSKDFLIKLK
                     EFKEKSMYMSTDEFIWYLYTRTGYYAYVGALPGGSQRQANLKVLFERAKQFEETSLKG
                     IFNFVNFIEKLKKSSSDMGSAKTLGENANVVRIMSIHKSKGLEFPVVICSAMGKNFNT
                     QDFKKSILYHHNLGYGPQFVDYERRISFPSIAKEALKSKINIENLSEEMRVLYVAFTR
                     AKEKLIITGSTRNIQDSIKRWSNGIESLDTISQYEILKGKNFLDWIMPCVLRHRDLSN
                     LLEEVGLDAVFNVEHNSKWYGKLWNKSDILVEKKSDEEKESIEEILEKIDVDNPDSDY
                     YSEIEEKLNYIYPYEFSTRKPATISVTEIKKIQNNYEEELINTIFEQKVILKKPLFIQ
                     NEEEREKISGTERGTIVHLVMEVLDLKNVSSVNDIKSQIRGFVSKGIITEKQASIVNP
                     YKIYKFFASNIGKRMLNAEIINREKSIYAQVNMKDIYIYEKLINNDDKKLYDNESVML
                     RGIVDAYFEEDNQIVLVDYKTDFVNEENINQIIEKYKKQLDLYADIIETLTGKSVKEK
                     CIYLFGVDEAVCY"
     gene            14937..16148
                     /locus_tag="KR257_001375"
     CDS             14937..16148
                     /locus_tag="KR257_001375"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418859.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="exonuclease SbcCD subunit D"
                     /protein_id="HBH0030087.1"
                     /translation="MRFIHTSDWHLGKSLEGHSRIEEQAKFCEEFIKIVESNEIDMVI
                     IAGDVYDTSNPPAQAEKLFYQTVSRLANNGQRCVLIISGNHDNPERLSAITPLAHEQG
                     ILIYGYPLSATIEAKYKGFEITYATQGCTKLNINGENIVVATLPYPSEKRLNEVFSSE
                     DEFEKQKNYSEKVGDIFRSLEENFRSDTINIAVSHIFVIGGESTESERPIQLGGSFLV
                     ERKDLPEKAQYTALGHLHKQQKASERLNAYYSGSPLQYSKDERAYTKGAYIVDIKAGE
                     KPIIEDVYFNNYKPIEVFKCNGIEEALDICEQNQDREIWSYFEINTDEIISQNEIKKM
                     KELLKDIIEIKPIITSCYEQESVDIKEKSMAELFREFYSFSKGVEPKGELMDLFLDII
                     SEEGESADETN"
     gene            16135..19662
                     /locus_tag="KR257_001376"
     CDS             16135..19662
                     /locus_tag="KR257_001376"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729493.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AAA family ATPase"
                     /protein_id="HBH0030088.1"
                     /translation="MRPIRLELTGLNSYIDKQVIDFEKLIERGLFGIFGTTGSGKSTI
                     LDAITIAMYGNISRNTKEYINSVCDKAIISYEFEIGSKNTRRRYIVDRTIARSKTGTK
                     TSNARLIEVLNDNTQNVLADKVVEVNEKVAQVVGLTANDFTRSVVLPQDKFNEFLRLS
                     RADRRDMLERIFNLEKYGRSLGEKVKKRKNIQLQNLKDLKSKLSQYDGITEEVYNNIN
                     QELIELKNLEKDKNNALDLAQKSYEESKTVYEEQLKLEKNELRKNELDLKNSEIKEKI
                     ALVENDSNAKKVDPYISSVQNLEKKIDEDSFAVSNLEKKLAILNQELEVTKNRYEKIN
                     KIKNEEIPKLSEEKIRLQQAIKLEEELVLLDRELKELKESGINLNKTKVELEKVKQVS
                     ESRKDAVTKSIKEVEGKIDKVNISAELKQKIFLAYEYEKDYNNVLEEKNQKLNKLEEI
                     LKETENINLKVRYIDKDKNDVNRNLENLSLHLDVLLKKCPGKSADLLLKSEYVTELRN
                     KANNTKENEIKKSSIQDELKIILESKFNTEREVNLLNEKLENNRKNRDDLEKELEELK
                     YLNLASELRRELKENMPCPVCGSKHHENHDITKYDENISFVKEKLEKLEKEKISIRNN
                     IEELNAKVSGYLSIEKMKTKELEDVKGKLGGIPSSQLLKKLDEEQRKLALLKSNIQEW
                     EKEKESTENKVTLAKEEKNKIEKEELKIRESLNNYKKLTRDLNIEIEGLENKCKKLKQ
                     EYLGLKTITKVSNLLSKVKEIRENEKELELLSTGHSNLLKNRDSLDIKIRENESKLHE
                     IEIELIKARELYVEKKLSRDNKYKEVISITKGDLAKNLLHNVEENICKILEQEESSKK
                     KLEEQRLEYEKNIAEKHNIDGRLKTAKEQYKDQKSTLNKLLAENKFESIYAVKRALLD
                     TDAVKKLIEEILEHEEEQKLLSFKIKSSKEKLNGRSIKKEYFEQLKDEIYNLKVEIGN
                     ISKDIGANQNQLITLKDSLDKINDFNKQLKVVEHNVDLLEELDKCVQGNKFVEYVSTN
                     QLKYIALEASKRLDGITKGRYALEIDSTLNFVMRDNFNGGERRSIDTLSGGETFLTSL
                     SLALALSSQIQLKGSAPLEFFFLDEGFGSLDSELLEIVIESLERLHSNNLSVGIISHV
                     EELKNRVPVKLLVSSSEAGIGSKVKIEYS"
     gene            19793..21046
                     /locus_tag="KR257_001377"
     CDS             19793..21046
                     /locus_tag="KR257_001377"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418863.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HlyC/CorC family transporter"
                     /protein_id="HBH0030089.1"
                     /translation="MLESPNNLIQIIFLIVLLIGSAFFSASETALMSLSKIRIRYMQD
                     EGVKGAKLVSSLIENPNKLLSSILVGNNVVNIAATSISTSLFIGLMGEKGVALATAVM
                     TVLVLIFGEITPKTIAANNSEKVSLLVSKPIKAIIFILRPIVWIFNIITNIIFKLFGI
                     TNKGAKSFITEEELKTMVNVSHEEGVLEMEEREIINNVFEFGDMQAKNAMVQRIDMVA
                     IDMEDSYDEIIQVFKTEKLSRMPVYEETIDDIVGILNIKDIIFLSDEEIESFDIKNYM
                     REPFFTYEFKKITQLLEEMKLEKSQMAIVVDEYGGTSGLLTIEDLVEVIVGDIEDEYD
                     EEEDEIQVIKEDEYIVDGSTKIGDVNELIGVNLESEEFDSIGGFIIGHLSRLPEENEV
                     IEVDNIRFCIESIEKNRIKKIRIYT"
     gene            21195..22247
                     /gene="ytvI"
                     /locus_tag="KR257_001378"
     CDS             21195..22247
                     /gene="ytvI"
                     /locus_tag="KR257_001378"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437952.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sporulation integral membrane protein YtvI"
                     /protein_id="HBH0030090.1"
                     /translation="MSILENNFLYKLKNNTIFFCIYTLLFIFIYKAFPYIAPFFLGAI
                     IALMINPISQKLENKFHINKGISTLVLSFLAVAIVSTVTTIIVINSMKELMGFLNNIS
                     ANPEDISNTIMYFLNKINDFMKSFQEIANFDVEQLVNKFSGEVMQITKNLLTSILGLA
                     TSIPYIIIFIITLFIATYFIAKDLDKIENSFYNMFTVDVRKKVKNVKKEAGLSLVGYI
                     RAYTILMAITFFAIWGSFALFGLKYGLIVGFVGALMDLIPFLGIITIYLPVIVYYFLI
                     KNYFIAISMTVIFFVLSLIREILEPKLVSVNVGLNPLATLAAIFIGIQVKGIIGVIFC
                     LGLVCMHDILKKVDIF"
     gene            22337..23563
                     /gene="pepT"
                     /locus_tag="KR257_001379"
     CDS             22337..23563
                     /gene="pepT"
                     /locus_tag="KR257_001379"
                     /EC_number="3.4.11.4"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888862.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptidase T"
                     /protein_id="HBH0030091.1"
                     /translation="MKQKVVERFLKYVSFDTTSNSQCENCPSSEGQRVLAKYIVEELK
                     TMGVDDVSLDENSYIMATLKGNTDGVDTIGFISHLDTIEDVSGKDIKPKIIENYDGKD
                     IVLNEALNVITYVKDSPELEEFKGDDLIVTDGTTLLGSDDKAGIAEIVTAIEYLINHP
                     EIKHGDIKIGFTPDEEIGRGADLFDVEKFGAKYAYTLDGGIVGELECENFNAANATIT
                     IHGRNVHPGSAKNKMVNAIHIAAEISEMFPADERPETTEGYEGFWHLNSIGGNVENVS
                     MAYIIRDHCKEKFENRKSIMIENIEKINKKYDNRVELDLKDSYYNMKEKIEPVMFIVD
                     IAKEAMEELGIKPRLVPVRGGTDGARLSFNGLPCPNIFTGGLNFHGKNECIPVSSMEK
                     ATKLIVRIAEKYAERV"
     gene            23770..24822
                     /locus_tag="KR257_001380"
     CDS             23770..24822
                     /locus_tag="KR257_001380"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437956.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell wall-binding protein Cwp18"
                     /protein_id="HBH0030092.1"
                     /translation="MKIKSKKIIAFALSLGIMLPSCVYADNISKNQNAQVDMNNYLQG
                     RKSPKEEKLIGEDRFDTAIKISQSGWNNGSERVFLVNSNSLPDALASTPLASKLDAPI
                     LLTNKNSIPYNVTEEIKRLNPAEVILIGSEGAISSSVKESLEDMEVLVSRIGGADREE
                     TSLLLTRQLDDTGDLGVSKVAVVNGYNGLADATSISSPAASDNTAIIYTGKDSIRSEA
                     KNFITQNSTKTYIVGGEYSISKKLEGQLVNSERLAGTDRKDTNAKVLEKFYGKSSKVN
                     NMYFAKDGSGREADLVDGLAAGVLASKTKSPVVLASGSLSSAQKSFIKKVKADKFVQV
                     GGGKNSKPYAEALALQ"
     gene            complement(25240..25809)
                     /gene="yfcE"
                     /locus_tag="KR257_001381"
     CDS             complement(25240..25809)
                     /gene="yfcE"
                     /locus_tag="KR257_001381"
                     /EC_number="3.1.4.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428581.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphodiesterase"
                     /protein_id="HBH0030093.1"
                     /translation="MKIGIMSDTHGSLLYFEKALNVLSDCDVLLHGGDVLYHGPRNDI
                     PEGYNPKKFIETLNKLENIVIVKGNCDADVDQMVIEHPIQSPYVMSQFGEIRIILNHG
                     YIESEEEIIDKAKKMGGDILVLGHTHVKKLYMDDNLIVINPGSTSIPKDGSHSVAIID
                     IIKTDDEDELELDINLIDINTGNIININD"
     gene            complement(25834..26634)
                     /locus_tag="KR257_001382"
     CDS             complement(25834..26634)
                     /locus_tag="KR257_001382"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418878.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NAD(+)/NADH kinase"
                     /protein_id="HBH0030094.1"
                     /translation="MKRIITINTNQLNKSLETKELLTRKLINAGFEVYSDIYPDTELI
                     ISIGGDGSFLRTVRDFDFPEIPIMGINTGHLGFFPDILPDKIDSFIEAYTKKDYIIQE
                     MSLLNAEVYTTTSGSNMLAVNEVVIRGDKSRTIHLNLSLDNKHIQNFSGDGMIISTST
                     GSTAYNYSAGGSIVDINLELMQITPLHPINTNAYRCFTSSIICSNESVIKIAPEYRFE
                     DSVLIVVDGVEHRFRQIENIKVSISDAKIKLLRMSNYEFWHRVSEKFL"
     gene            26769..27629
                     /locus_tag="KR257_001383"
     CDS             26769..27629
                     /locus_tag="KR257_001383"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888863.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBH0030095.1"
                     /translation="MFSIRNITKKLGKFKLNNINLELKEGDIVGIIGPNGSGKTTLIK
                     IIMGIIDADEGEIELCNETIENSPISFKNNIGFVYDSLQFYPHLKVKEFRKIVSLFYK
                     NFDRERFDEYLNKFDIEENMHIENLSKGQSEKLMLSSALSHNAKLLILDEPTAGIDPI
                     VRTEIMQYLQDFVKNGSSSVIISTHNTDNLIKIADYLVFINRGNQIFTVKKELIEQEY
                     KIIRANKAELEAIKESIVGVKEYKYYNEALVKVGDSLKVKSLLIEIDKHKVKNPTIEE
                     LMYYYVNEVR"
     gene            27629..28315
                     /locus_tag="KR257_001384"
     CDS             27629..28315
                     /locus_tag="KR257_001384"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009905296.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC-2 transporter permease"
                     /protein_id="HBH0030096.1"
                     /translation="MFNLIRKDLIIGISSDGIRNLKYILLFFVFYFFLNSISYYTVSI
                     VVSYLIFINTFECDYENDSRIFIRSMPVSIEDIVYSKYLLGVGLIISVTIIVSLLSKL
                     TSLVFFRNMVLNDVFFSVNIFLAILTILLPLIFKFGYGKMKVCGFIVSILIYFVYGSL
                     LKMISMIVYQVKHFNYSKVGGVYLSNYVTDIANTKYINLYSMTFLTIIIFIISMYFSI
                     KISKKNKFNY"
     gene            28367..28909
                     /locus_tag="KR257_001385"
     CDS             28367..28909
                     /locus_tag="KR257_001385"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888864.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0030097.1"
                     /translation="MKKFIKVSFFILGIFTLFIAINKLVYRDMVSVKDYEINHLEEIV
                     FDFDSRRSRDVGTIVRFKISNNSKYSYKLNSAKMKFENCVENKKGMNKCSAYVNVDLF
                     NEKNSITERTLKYGIKPNNQGYVDFVIPKGLNFDYRYFNESGMSVEYKGEYIVNIPMA
                     KGLYLVVGKNNDTWNANIME"
     gene            28988..29455
                     /locus_tag="KR257_001386"
     CDS             28988..29455
                     /locus_tag="KR257_001386"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428574.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YbaK/EbsC family protein"
                     /protein_id="HBH0030098.1"
                     /translation="MSISNVREYFKQFGKEDSILEFEQSSATVELAAEAAGVIPARIA
                     KTLSFKIGDDAILIVTAGDAKIDNKKYKAEFNCKAKMLTPEEVLEFTGHAIGGVCPFG
                     LKNSIKVYLDDSMKRFDTVFPACGSSNSAIELTCEEMEKFSKCEKWVDVCKNW"
     gene            30164..31300
                     /locus_tag="KR257_001387"
     CDS             30164..31300
                     /locus_tag="KR257_001387"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418888.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="acyl-CoA dehydrogenase"
                     /protein_id="HBH0030099.1"
                     /translation="MDLNSKKYQMLKELYVSFAENEVKPLATELDEEERFPYETVEKM
                     AKAGMMGIPYPKEYGGEGGDTVGYIMAVEELSRVCGTTGVILSAHTSLGSWPIYQYGN
                     EEQKQKFLRPLASGEKLGAFGLTEPNAGTDASGQQTTAVLDGDEYILNGSKIFITNAI
                     AGDIYVVMAMTDKSKGNKGISAFIVEKGTPGFSFGVKEKKMGIRGSATSELIFEDCRI
                     PKENLLGKEGQGFKIAMSTLDGGRIGIAAQALGLAQGALDETVKYVKERVQFGRPLSK
                     FQNTQFQLADMEVKVQAARHLVYQAAINKDLGKPYGVEAAMAKLFAAETAMEVTTKAV
                     QLHGGYGYTRDYPVERMMRDAKITEIYEGTSEVQRMVISGKLLK"
     gene            31359..32141
                     /locus_tag="KR257_001388"
     CDS             31359..32141
                     /locus_tag="KR257_001388"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009524639.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="electron transfer flavoprotein subunit beta/FixA
                     family protein"
                     /protein_id="HBH0030100.1"
                     /translation="MNIVVCIKQVPDTTEVKLDPNTGTLIRDGVPSIINPDDKAGLEE
                     AIKLKEEMGAHVTVITMGPPQADMALKEALAMGADRGILLTDRAFAGADTWATSSALA
                     GALKNIDFDIIIAGRQAIDGDTAQVGPQIAEHLNLPSITYAEEIKTEGEYVLVKRQFE
                     DCCHDLKVKMPCLITTLKDMNTPRYMKVGRIYDAFENDVVETWTVKDIEVDPSNLGLK
                     GSPTSVFKSFTKSVKPAGTIYNEDAKTSAGIIIDKLKEKYII"
     gene            32160..33170
                     /locus_tag="KR257_001389"
     CDS             32160..33170
                     /locus_tag="KR257_001389"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418892.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="electron transfer flavoprotein subunit
                     alpha/FixB family protein"
                     /protein_id="HBH0030101.1"
                     /translation="MGNVLVVIEQRENVIQTVSLELLGKATEIAKDYDTKVSALLLGS
                     KVEGLIDTLAHYGADEVIVVDDEALAVYTTEPYTKAAYEAIKAADPIVVLFGATSIGR
                     DLAPRVSARIHTGLTADCTGLAVAEDTKLLLMTRPAFGGNIMATIVCKDFRPQMSTVR
                     PGVMKKNEPDETKEAVINRFKVEFNDADKLVQVVQVIKEAKKQVKIEDAKILVSAGRG
                     MGGKENLDILYELAEIIGGEVSGSRATIDAGWLDKARQVGQTGKTVRPDLYIACGISG
                     AIQHIAGMEDAEFIVAINKNPEAPIFKYADVGIVGDVHKVLPELISQLSVAKEKGEVL
                     AN"
     gene            33189..33986
                     /locus_tag="KR257_001390"
     CDS             33189..33986
                     /locus_tag="KR257_001390"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428571.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="enoyl-CoA hydratase/isomerase family protein"
                     /protein_id="HBH0030102.1"
                     /translation="MSTSDVKVYENVAVEVDGNICTVKMNRPKALNAINSKTLEELYE
                     VFVDINNDETIDVVILTGEGKAFVAGADIAYMKDLDAVAAKDFSILGAKAFGEIENSK
                     KVVIAAVNGFALGGGCELAMACDIRIASAKAKFGQPEVTLGITPGYGGTQRLTRLVGM
                     AKAKELIFTGQVIKADEAEKIGLVNRVVEPDILIEEVEKLAKIIAKNAQLAVRYSKEA
                     IQLGAQTDINTGIDIESNLFGLCFSTKDQKEGMSAFVEKREANFIKG"
     gene            34084..34929
                     /locus_tag="KR257_001391"
     CDS             34084..34929
                     /locus_tag="KR257_001391"
                     /EC_number="1.1.1.157"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428570.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="3-hydroxybutyryl-CoA dehydrogenase"
                     /protein_id="HBH0030103.1"
                     /translation="MKLAVIGSGTMGSGIVQTFASCGHDVCLKSRTQGAIDKCLALLD
                     KNLTKLVTKGKMDEATKAEILSHVSSTTNYEDLKDMDLIIEASVEDMNIKKDVFKLLD
                     ELCKEDTILATNTSSLSITEIASSTKRPDKVIGMHFFNPVPMMKLVEVISGQLTSKVT
                     FDTVFELSKSINKVPVDVSESPGFVVNRILIPMINEAVGIYADGVASKEEIDEAMKLG
                     ANHPMGPLALGDLIGLDVVLAIMNVLYTEFGDTKYRPHPLLAKMVRANQLGRKTKIGF
                     YDYNK"
     gene            35016..36191
                     /locus_tag="KR257_001392"
     CDS             35016..36191
                     /locus_tag="KR257_001392"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000786547.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="acetyl-CoA C-acetyltransferase"
                     /protein_id="HBH0030104.1"
                     /translation="MREVVIASAARTAVGSFGGAFKSVSAVELGVTAAKEAIKRANIT
                     PDMIDESLLGGVLTAGLGQNIARQIALGAGIPVEKPAMTINIVCGSGLRSVSMASQLI
                     ALGDADIMLVGGAENMSMSPYLVPSARYGARMGDAAFVDSMIKDGLSDIFNNYHMGIT
                     AENIAEQWNITREEQDELALASQNKAEKAQAEGKFDEEIVPVVIKGRKGDTVVDKDEY
                     IKPGTTMEKLAKLRPAFKKDGTVTAGNASGINDGAAMLVVMAKEKAEELGIEPLATIV
                     SYGTAGVDPKIMGYGPVPATKKALEAANMTIEDIDLVEANEAFAAQSVAVIRDLNIDM
                     NKVNVNGGAIAIGHPIGCSGARILTTLLYEMKRRDAKTGLATLCIGGGMGTTLIVKR"
     gene            36387..37289
                     /locus_tag="KR257_001393"
     CDS             36387..37289
                     /locus_tag="KR257_001393"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428566.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RluA family pseudouridine synthase"
                     /protein_id="HBH0030105.1"
                     /translation="MFKKENQRYNLISYTNEEEMTLKEVLLDKLNFSVRSLSKMKREK
                     SVLVNGVYKKPSLKVYSGDLIEVKIDEEKANFEPQDLNLQIIYDDFDIIMVNKPPFMV
                     VHPTKSHYDKTIANGISYYIDNQKENVKIRFVNRLDMNTSGLVIVAKNAYAHHTLSTA
                     MSENKVEKKYITVVDGIIKENEGTIDEPIYRPTEDSIKRIIDERGQSSVTHYKVIERL
                     ENATVLEVSLETGRTHQIRVHMAHIGHGIIGDELYGYVDEDLINRQALHAYKLEFEQP
                     RTKEKLKFKADIPEDMKELISKLR"
     gene            37303..38307
                     /locus_tag="KR257_001394"
     CDS             37303..38307
                     /locus_tag="KR257_001394"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729497.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nucleoid-associated protein"
                     /protein_id="HBH0030106.1"
                     /translation="MIIHKFIIHVLDKNSDVPILNDFEGKVNQEVDGFFQKAIKRIAK
                     DEDLRKGVFKDYNDNLIKNCCEQIIYDESTFLKNSKEIASYLFDVMKINAALESCDLA
                     ICLYTIKDEKSVAILKLDYKKLYTHSIEFVDDKFNIQMVSNEIGIPETLRQKQGALIS
                     LSGINDEFHLRLLDKDAEKEGSESKFVTEFLNAKKIDDDKYKTKVFKNTAENWITNAL
                     SNDIKQAEDVRSILNYTLKEKHEVDINDFVDNSIKDDELKDSFKEHMEEKGLDESFSI
                     DKKWVEKKLKKRSIKTDNGFDIKGNLTDFEDPMKYTVKQNQDGTIDIIIKNVTFYEEK
                     "
     gene            complement(38451..38678)
                     /gene="acpP"
                     /locus_tag="KR257_001395"
     CDS             complement(38451..38678)
                     /gene="acpP"
                     /locus_tag="KR257_001395"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418905.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="acyl carrier protein"
                     /protein_id="HBH0030107.1"
                     /translation="MFEKIKEIIAEQLGVDNLDEITMEASLMDDLEADSLDAVEIIMA
                     LEDEFGIEIPDEEAENFKCIGDICKYIEENK"
     gene            38850..39275
                     /locus_tag="KR257_001396"
     CDS             38850..39275
                     /locus_tag="KR257_001396"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428561.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0030108.1"
                     /translation="MKYVGLLLTSVGMFLLIAVNFYYNSITLDMQRIEDYVMETNLIL
                     EDVAEKESYVSNEKEDYISRLMHVKKGIENSKTSFLIERYKEYKIKSIESLIYTISEE
                     KKDYLDEVDRYNKLGEKEINKLINKNFLEVTYLSITTYI"
     gene            39323..39529
                     /locus_tag="KR257_001397"
     CDS             39323..39529
                     /locus_tag="KR257_001397"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888870.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0030109.1"
                     /translation="MTKLEDNMERFFGGCEGFFGNKMLIIIVIVFLLLCTDILEDLLC
                     DDNIWIWVILIVLLLFNFDDGCCC"
     gene            39711..39890
                     /locus_tag="KR257_001398"
     CDS             39711..39890
                     /locus_tag="KR257_001398"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418911.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0030110.1"
                     /translation="MLDRFFGEEGCFGGGGWWIIVLFFLFLAFGDSWAEFDIMAWIPF
                     LIVLLILCCCGGCLE"
     gene            39924..40124
                     /locus_tag="KR257_001399"
     CDS             39924..40124
                     /locus_tag="KR257_001399"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428556.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0030111.1"
                     /translation="MLDRFFGEEGCFGGGGWWIIVLFFLFLAFEDCWRDIDIMSWIPF
                     LILLLITCSCGGFFDGEVGCGC"
     gene            40377..41393
                     /gene="ccpA"
                     /locus_tag="KR257_001400"
     CDS             40377..41393
                     /gene="ccpA"
                     /locus_tag="KR257_001400"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888871.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LacI family transcriptional regulator CcpA"
                     /protein_id="HBH0030112.1"
                     /translation="MKGNITIKDVAKQAGVSISTVSRVINDSKPVTDEVKQKVLEVIK
                     ETGYIPNPLARSLVTKKSQLIGVIVPEVSDSFVNEVLNGIEEVAKMYDYDILLANTYS
                     DKEQELKSINLLRAKQVEGIVMISWIVEQEHINYIQNCGIPATYISKTARNYDIYTVS
                     TSNEEATFDMTEHLIKKGHEKIAFIMTSKDDTVLEMERLAGYEKALSNNNIELDKSLI
                     KYGGTDYESGYNSMKELLDDGIIPHAAFVTGDEAAIGAINAICDAGYKVPEDISVAGF
                     NDVKIARMYRPKLTTVYQPLYDMGAVAIRMVIKLINKELIENKKIELPYRIVDRESVT
                     ERKK"
     gene            complement(41516..41914)
                     /locus_tag="KR257_001401"
     CDS             complement(41516..41914)
                     /locus_tag="KR257_001401"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009905301.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0030113.1"
                     /translation="MKKLDTESLEKMAKQKNIDKDKIEKMADSYKGKSENELMEELIK
                     IGKNLDGRDEVVSKFKAFLDENQRKKLDNIMEKISDAENQRDTKPAKTKKAKPTKGKS
                     NSPAPKNTPGSQQKKSKSLFKKTKKSNPHE"
     gene            42126..43031
                     /locus_tag="KR257_001402"
     CDS             42126..43031
                     /locus_tag="KR257_001402"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892884.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0030114.1"
                     /translation="MNNLLFLIGVIALSNGNISIFDDKNKSKGNNRVRKNKKNANDKL
                     SQSTHGNLRFDANDIKRGLRLMDLSEEDLEMGMEIITRTKKYMSRDERKILIKIESVL
                     DLVRGIKKLNNIDMVDTEDETDFFRKMDSDDKKNMMIKEIIDVFPEKRKNSVEKAIGM
                     KKKIDLFAELFLPDDFGEGGFSLSSLANINNLGSMNNLKLLGSLLRGDDSNNDDEDNN
                     DELNYEDEELDCEDKELDDDELTDEGEMEDNEDELVEDKNTGYENIENDEDIVYDEEL
                     YNINEQESEYNYNEKNTKTRAKKKR"
     gene            43146..43326
                     /gene="ssrS"
                     /locus_tag="KR257_001403"
     ncRNA           43146..43326
                     /ncRNA_class="other"
                     /gene="ssrS"
                     /locus_tag="KR257_001403"
                     /product="6S RNA"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00013"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: cmsearch."
                     /db_xref="RFAM:RF00013"
     gene            43509..44726
                     /gene="cdeC"
                     /locus_tag="KR257_001404"
     CDS             43509..44726
                     /gene="cdeC"
                     /locus_tag="KR257_001404"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437985.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="exosporium morphogenetic protein CdeC"
                     /protein_id="HBH0030115.1"
                     /translation="MQDYKKNKRRMMNQPMSTMNEEEVYTDEINSEDMRGFKKSHHHN
                     GCNTDNKCECHDDCNPCNPCNPCKPNPCNPCKPNPCDDNCGCHDNCKCDCEPCEMDSD
                     ECFENKCGPECCNPISPRNFSVSNAVPFAIEANRIFDTMQFQTFTDATGPNGEPLTFE
                     TEVVEVFGSVPSAGQASVTIEKICLSNDGIVIDTGMTTLEDFDLDPLGDIVGRNCETT
                     FEFAVCGERNSECCRQGKGKSVAYKQRGLTVAVRNLVLELRGRCGCTEFVALAFPAVR
                     AGGGCKRRVDYVEFTFNTLSAPICLPADGRAVTLRQEYQTNLTVDCIGKSILKLECNE
                     CCEPFYELIIPNDIDLVLCLQETVSTLISEQIVVLASPNPIQPRLVDTFSKVCDFSQC
                     GPNHGSGKPSCHR"
     gene            complement(44826..46148)
                     /locus_tag="KR257_001405"
     CDS             complement(44826..46148)
                     /locus_tag="KR257_001405"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888874.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="polysaccharide biosynthesis protein"
                     /protein_id="HBH0030116.1"
                     /translation="MKVPYLVLSTVILFISNFIVRIFGFLYKIFLSRALGETGLGIYH
                     MIFNFLMICLAVTTTGIPTALSCLVAKRKALNDRHNTNALFISTLYISFFVALIISIV
                     ASFNSSFLSLKFLKDAKLNLFILAVCPAIVIITLSNVLRGYYYGIKNVKIPAIGQIIE
                     QIGKILFVFLLVMYINNKSMNCYIALLGISIGELSNIIFMLICLWRDSSFDNRYIISI
                     KDFYNSSMETLKMSIPITCNRMSNILLQSISSMMIPSRLALSGMTYQQSLSMYGIVSG
                     MVMPFIFLPFTVGSALIVNLIPTISQEMALRKRKSVIKKIKYSILLTLFVGILSSIFF
                     YFFGKDLCILVFKNTLAGEYLKAMFLVPLFMSLNQTLSGILHSIRKELASSINTITGM
                     LIQLIALYVFLPIPGLNIYAYIYTMTIVSIFTCLLHTIVLFKSLKSIR"
     gene            complement(46199..46993)
                     /locus_tag="KR257_001406"
     CDS             complement(46199..46993)
                     /locus_tag="KR257_001406"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896027.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="histidinol-phosphatase HisJ family protein"
                     /protein_id="HBH0030117.1"
                     /translation="MFYDYHMHSSFSTDGKSTMEEMVKKSIELGLEEICFTDHVDYDV
                     YADDSFSIVYEDYFKSLETLQSKYKDKISIKKGIEFGVQTQLMDTYKKEAHQYPLDFI
                     ICSIHAIDTMDLYLGNYFKDKTQHEVYENYYLYLYNIVKNYKDYSVLGHLDLIKRYAP
                     YDTILDDRLFSDIIEETLKQAIYDGKGIEINTSCYRYNLPDLTPSKYILQMYKDLGGE
                     IITTGSDSHHISQVACEFDYIYSLLKNMGFKYVSKFNKLKPEFIKL"
     gene            47103..48548
                     /locus_tag="KR257_001407"
     CDS             47103..48548
                     /locus_tag="KR257_001407"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888876.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PLP-dependent aminotransferase family protein"
                     /protein_id="HBH0030118.1"
                     /translation="MEKYRIDLNEKKSTKYIQIFNHIKELIINKELVEHEKLPPIRKL
                     SNFLQVNNTTIVKVYELLENEGYVYKIIGSGTFVSSLNSYKSGIDNRKNKIIVQREDL
                     IHFDNGNPSNDMFPIDSFKNAVNMALSKDGSSIFEYDEGLGSEELREKMVEYLSDGNI
                     KTTKENIQIISGAQQGIDIVCKGLISYSDVVFMEEPSYNGAIEVFKSRGAKIISIPML
                     DDGIDIGILKLKLEKIKPRLIYIMPNFQNPTGISYSTYKKKKLIELAEEHDFYIIEDD
                     FISDFVFESKDNRTIRSYDDKNRVVYIKSFSKILMPGLRIGIVEMPNELLKKVLWAKY
                     SSDISTPGLIQKSMYYYMNNFDWKNYLSHIEKIYTDKYKLAKNLINDKLSGKLKVRKS
                     CGGINFFLELPRGYTSQAFTNFMLNKGVSMLPGTYFFDNLVDDRFFRINIARPSMEEL
                     EKGISIISDNIDEFFCEYKNKLDIKSNKLFY"
     gene            48577..48786
                     /locus_tag="KR257_001408"
     CDS             48577..48786
                     /locus_tag="KR257_001408"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418943.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF896 domain-containing protein"
                     /protein_id="HBH0030119.1"
                     /translation="MFDKKKLDRINELAKKNKEGILSADEIKEREILRKEYLENFRAH
                     FRSRLDSVKVVSPEEYEQYMKNNKN"
     gene            48806..50200
                     /locus_tag="KR257_001409"
     CDS             48806..50200
                     /locus_tag="KR257_001409"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861085.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aminopeptidase"
                     /protein_id="HBH0030120.1"
                     /translation="MNLKYEFKNAWDFERKENTIEQIMQYSSNYMEFLSKSKTERLSV
                     KEIIKLAKENNYISIDEAMEKGSISCGDKIYVINKEKAVALFVIGKNYIEKGMKIIGS
                     HIDSPRLDLKPNPLYQESNLGFFKTHYYGGIKKYQWTAIPLALHGIVILNDGTKVDIS
                     IGEEDSDPVFCVTDLLIHLAGDQMQKKLSEGISGEALNILIGNMPLEDEEKEPITANI
                     LKILNEKYNIVEEDLLSAEIEVVPAGKARDLGLDRSMVLGYGHDDRVCSYAAVKAILE
                     TEQPEFTSVALCVDKEEIGSKGNTGMHSKFFENTVAELIALEGDYCDIKVRRALANSK
                     VLSADVSAGYDPNFGEAYEKRNSAYMGNGVVLTKYTGSRGKSGCNDANAEFMSEVKRI
                     FNKGNVVWQTAELGKVDQGGGGTIAHILANQGAEVIDCGVGVLNMHAPHEIVSKVDIY
                     EMYKGYKAFFNINL"
     gene            50440..50625
                     /locus_tag="KR257_001410"
                     /pseudo
     CDS             50440..50625
                     /locus_tag="KR257_001410"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896033.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="winged helix-turn-helix transcriptional
                     regulator"
     gene            complement(50734..51900)
                     /locus_tag="KR257_001411"
     CDS             complement(50734..51900)
                     /locus_tag="KR257_001411"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017752472.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="site-specific integrase"
                     /protein_id="HBH0030121.1"
                     /translation="MKGGVRKRGKKWYYYFDAGIVDGKRKKVERVGGNTKKEAEKSLR
                     DAINEYENAGIVFDETNMSLSDYLNFWYKEYVLLNCKYNTQESYRNLIENHIEPRLGK
                     CKLKSINPAIIQEFLNNKSKETYTQNGEEKHYTKGVLKAIYVVLNAALKSAVYPYKLI
                     KENPVQYASIPKNVLKVKNESDNKTITLDEFNKILEIYPKNTNIYIPLLIGFHTGMRK
                     GEILGLCWDNVDLDNNIIKVRKNLIKRKVSEFELASPKTKTSIRDIKIGDTLSRILKE
                     EKLNQKKQKIKIGKWYKETEYDWVCRKKDGSFVNHNNIDAAIRTINKKLNINFNFHCL
                     RHTHATLLLENGANVKYIQQRLGHSQLSTTMDTYSHVTSKMESETIDILEGILQ"
     gene            complement(52038..52244)
                     /locus_tag="KR257_001412"
     CDS             complement(52038..52244)
                     /locus_tag="KR257_001412"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0030122.1"
                     /translation="MNLSFNKKKKFELSKEELELIENWLGNKYAGDMTIPAIVDFSLE
                     TDIEYEKIVVYLAEKVLESRDKKH"
     gene            complement(52303..52527)
                     /locus_tag="KR257_001413"
                     /pseudo
     CDS             complement(52303..52527)
                     /locus_tag="KR257_001413"
                     /inference="COORDINATES: protein motif:HMM:NF024835.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
BASE COUNT        21396 a         5532 c         9208 g        16632 t
ORIGIN      
        1 tcaagagctg gagtattcat ttgtaataca caatataagc ttaattacta tattttattg
       61 tgtgtttttt gtggattttt atgtcaataa atgatatagt atagataatt aaatgtatta
      121 aatatattta atttttttat tttttgagtt ttataagttt atttttatat attacttata
      181 tattacttat atattattta tattttgggt tagatacact ttgacatatt ttcaaaagtt
      241 aaaagattaa aaataaagta gaaatttatg ttaagtaagg agattaatat gagaagaaat
      301 acaaaattat taacaacagg gattctttca atggcaatcg tcgcacctac aatggcattt
      361 gctactgaat ctaatgctat ggaaaataac gctgatttaa atataaactt agagaaaaaa
      421 agtatcgttt taggtagcaa atcaaaagtt agtgtcaaat ttaaagaaaa accagatgca
      481 gatagcatta cattaaagta taaatgctat gacatgccat tggatacaac tctaaattac
      541 aatcaatcaa ctggggcata tgaaggaact atcaattata accaagaccc agaatatcta
      601 aatgtttggg aactacaagg gataacaata aacagcaaaa ataatcctaa aactttaaac
      661 agacaagacc tagaaaagct gggattaaat ttaaaagact ataatgtaac acaggaatgt
      721 ataattgaag acataacttc tagaaaagat gtaaataaat atttgagaaa aacttcttca
      781 cctattacag aacttacagg aagtgataga tatgaaacag cagttaaaat aagtaaagag
      841 ggttggaaaa atggttcaga taaagtagtt ataataaatg gggatgtaag tatagatggc
      901 attatatcaa ctccactggc aaccacatat aatgctccaa tacttttggt tgaaaaaaac
      961 aatgtgccta atagtgtaaa atcagaatta aagcgcctaa accctaaaga tataattata
     1021 attggagatg agaatgctat ttctaaaact actgctaatc aaattaaatc aactgtaaat
     1081 gctagtcaaa cacgtttaaa tggttctaat agatatgaga catctttatt gatagcaaag
     1141 gaaatagata aaaatcatga tgtggaaaaa atatacataa caaatgctaa tggcggagaa
     1201 gtggatgcac ttactatagc agcaaaagca ggtcaagaca agcaaccaat tatattaact
     1261 gataaagata gtattacaga caatacatat aaatggttaa agagtgagga tttacaaaat
     1321 gcttatttta taggtggtcc tcaaatgata tcaacaaatg ttataaataa ggtaaatgga
     1381 ataactaagg atagtgttac taataataga gtatacggag cagatagaca cgaaacaaat
     1441 gcaaacgtaa taaaaaaatt ctatacagat gatgagttag aggctgtttt agtagctaaa
     1501 tcagatgtac ttgttgatgc tttagcagca ggtccattgg ctgcgaactt aaaatctcca
     1561 atacttataa caccaaagac gtatgtatct gcataccata aagataattt agaagctaaa
     1621 tcagctaata aagtatacaa aataggagga ggattgactt ctaaggtaat gagctctata
     1681 gcatcatcat tatctaaaca caatacgact ccaacagaac caggaaatag tgggggcaag
     1741 acagttatga ttgacccagg gcatggtggt tcagcacctg gaaattcatc tggaggaatg
     1801 attgaaaaag attacaattt aaatacttca cttgcaacaa ctgaatattt acgttcaaag
     1861 ggattcaatg taataatgac aagagacaca gataagactt tatctcttgg aaatagaact
     1921 gctctatcta attcattgaa accagattta tttacaagta tacattataa tggctcaact
     1981 aataaacaag gtcatggtgt agaagtattt tataagctta aagataaaaa tggagggact
     2041 actaaaactg tagctaccaa tatattaaat agaattttag agaaatttaa acttacaaat
     2101 agaggtataa aaacaagagt acttcctagt gattctacaa aagattattt atacgtttta
     2161 agaagtaatg atatgccagc tgtacttgta gaatgtgcat ttttggataa tgaaaatgat
     2221 atgagtttaa taaactcatc tgcaaaagta aaagaaatgg gtacacaaat aggtaaagga
     2281 atagaagatt cattaaaata aatggaaata aaaatattta aaaacttaat gtaaatttat
     2341 agttgtaaat ttatactaaa gtcaaaaaat gaaatataag tgtatcaata gtaagactgt
     2401 atgtacattt gcacatgtga atgcaagtat atatacagtc tttttttgta gttaaatgca
     2461 ataatttgat tgtgttttgt aaaatacaca atatgatata attagataat atacacttaa
     2521 tttaattgag gaaggtgatt atatggaata tttatttgaa aaaagtagtt taaaagaata
     2581 tggaaatgaa gctttagata aatatagaga attattagat aaaactggta ataattcaag
     2641 gtgtattctt ttgttagtac caaacaataa cacaaagata cgatatgaaa gggctctaag
     2701 attaaattat agtgaagaac tgaaagtaac aacatatata agttttgtga agaaagaatt
     2761 agttaaatac tggccactaa taatagaaaa atgtgatgga ataagtacaa aggttgtatc
     2821 tccaacattt atatcaaata gtttaagtga atatttaata gtgcaaaaag ttaaggaaaa
     2881 aaggatacaa gaaggatatt ttgaagatat tacaggaacc aataaatcca tagcaaatag
     2941 tataatgact aacataaata agtctgcatt taatttaatt gattttgatt ttattggaga
     3001 aaaaatatat tcatcaaaga aaaataaaga tagtatatat agattttcat acactcaaat
     3061 ggatgaaatt atatcatatt atataaattc cttactatca aattcaattt tagataatgc
     3121 attaagcata tatttataca atcaatacct acttaatgat gatttttatt taaaaaactt
     3181 atttacagaa gtgagatata taattgtgga tagccttgaa agctcaagta atgcagaagt
     3241 tgattttata acagaagcat tggataatac attacaaagt tatatatatt ttgattatag
     3301 tagggattat tctgtattta ataatgtgga tatagactat ataaatgaga aaataatatc
     3361 aaaaattaag cctaaagaag aaaatattaa aaagaaggag attagaatag aagatttata
     3421 cttattacct gcaaatatag aattaaatca atcaagtcaa ttatataatg aaatgttaga
     3481 tttaataagt gaaaaagtta tatctcttat agaagaagat gtatctccaa gagatatagc
     3541 aattatatct cctataaaca atagtatatt ggagcatcaa attagagatt ctttgataga
     3601 aaaaaatata gatgttttta gtactaagaa ggataaaaaa gctgtggatt atccatatgg
     3661 gaatgcattg gtagtggcta catgtatatt ctatggatat ttagatttta taaaagatga
     3721 tgaatactta agctttttag aaactctttt agaaataaat aggataaaag catttaagat
     3781 ttttaatgaa acaagacatt taagtattga taatatagat gaacatagtc agtatcgtga
     3841 tattttacag tatattgaag aaaaaaagaa gagtgatata aaaatacatg aatttttaac
     3901 tcaattttac atagataaaa tgttaaattt aaaagaaggt aaaaagaatg ttgggttatg
     3961 taaaaagata atagctgaaa gtgagtcttt tagtgaaagt ttaagtctac ttgggatgaa
     4021 aaaagaaaag atatttgtag aagctttaaa aagtacaata aacgattatt actctgttgt
     4081 cgatatagaa gagttgaaat ccaaagacaa aatagtaata actactcctt attcatatat
     4141 atcatcaaat atagatagaa gtatacaaat atgggtagat ataggaagta atgcttggaa
     4201 tatgaaaata gaaaaagata taagtaattt aattgtactt agaaaatctt ttgaagaaaa
     4261 aaagatttat acaaatgaaa tggaagaata ttataaaaaa tattatctat acaatacagt
     4321 atataatttg ttattaaatg caaagaaaat ctatgcattt aaaagtgaat atgcgattaa
     4381 tggttatatc caagagagta tattatatag tatactttta aaaatctcac ataaaggaga
     4441 taaaaattat gattaatata aattatagag aagaccagat accaataata aattacgata
     4501 atggtactat ggcagtacca gcagtaccag gtgctggaaa aacatttata ataacaaatt
     4561 tagtagctaa actattactt gaacagaaac ataagagtgg taaaatatta attcttacat
     4621 atatgaatag tgctgtaaat aattttaaag gtagaataag aaagattctt gaagagaata
     4681 aaatagatga tactaattcg tatgaagtaa tgactataca cagtttggct gtaaaaataa
     4741 taaaggaaaa gccagaagtt gtaatgttaa gtgaggattt taacatagct gacgatttgc
     4801 aaaaaagtat tatattaaat gaatgtataa gtagatttag atttgaaggt ggagaaagag
     4861 cttttagatg gtttttaaag gagcaaaaag atgaacgctg gaaagaaata actcttgaag
     4921 cctgggaaag aggttttttt gaatttgcag gaaatgcaat aagtgaactt aagtataagg
     4981 gaatttctcc agataaactt gaagaaatat tgtcaagagg acacaaagga atacttaaaa
     5041 ttattttacc aatatataaa ttgtatgata gaaaattaaa gcaaaatgga ttgctagatt
     5101 atgatgatat attaatttta gcagaaaaaa ctttaagctt agacgaaggg cttagaaaga
     5161 agtttcaaac tagatacaaa tatatatttg aagatgagtg tcaggactca aatgaaattc
     5221 aaggtaatat aataaaaatt atatctagcg aaaataaaaa cctagttaga gttggagata
     5281 taaatcagag tataacagga acattttcat catcagaccc taaatttttt aaagaattta
     5341 taaatagtgc agatttctgt tataggatgg atatgtcaaa tcgaagttca aaagatatac
     5401 ttgatttagc aaacactctt gtcaagtatg ttacaaagga atttagacaa gaagaatgta
     5461 gacatgctct tgaagatatg caaataaaaa ctgtgccaaa tggaatggga tataaagaaa
     5521 accctaatcc agaacattat aatataaatg taaagtggta tgagagttgg aaaattgaaa
     5581 tagagcaaac tgctagatac gttaagggta taaaaaataa atatccagat aaaagtatag
     5641 gtatattggt tccatttaat gaacaagtga cacaagttgc taaagaactt agagagaata
     5701 atctaacctt tgaagaatta ggaccaaatt ctttgaataa aaggaaggtt ataaacaaca
     5761 tagcatatat tattgatttt atgttacatt gtgatgatgt agaaaagtta atagttgtac
     5821 ttaataaagt ttttatagat actgataatg aagaagaaat aaagtatttt ttagaagaat
     5881 taaaaaacta ttctaccgaa gaaattattt ataattttga atttagtaag ttagataatg
     5941 atttaataga atttaaagaa gaaagtgata tatacttaag ttttaaaaga ggaatagata
     6001 ttataaaaca gatattagaa tatccaataa taaggttaga cctcttagtt ttgtttattg
     6061 ggaaaaaact tagtttagaa aaagaagata aagctgtact ggattatata tctttttata
     6121 taaagtatct agtatcagaa aatataaata tggatttaga agatgtatat aatttattgt
     6181 ttgatgtaaa gaacagggtg tttaatcata taatagatgt ggtatatgag ataaatggat
     6241 atgaaccaga gcctggtagt ataacactat gtaactatca taaatcaaag gggatggaat
     6301 gggattgtgt gtttttacta ggtcttgttg aatataattt ccctgacaat attaatcaaa
     6361 agtttcagag tgataaatgg tatctaaaag aaaaatataa aaaccctatg gcaattatta
     6421 aatcagaagt tgaagctata ttaaaaggaa gtatttcaac agattatgct cataaaacga
     6481 agattgattc tataaatgaa aagattagac ttttatatgt agggattact agagcaaagg
     6541 aaatgttagt actttcagga agtgcttata gagatgaaag tgatataggg aataagagaa
     6601 aagagcaaaa accatgtata tatttaagca gacttaatca acatattatt gaaaaaaggt
     6661 caaattaata tataataagt tattaaaaga ttgtttgaaa tatatctaaa agaggataaa
     6721 acaatatgta cagtaagtaa ctactaaaaa ataaagttaa gagagaagtg atatgagtga
     6781 acgataaatt aaaatatttt tcttatagtc aaaattcaat taacacatat aaatcatgtc
     6841 cattgaaatt taaatataaa tatattgata gaataaattg gaaaaatgat gatgttggta
     6901 gtagagagta ttatgaaact ttaaaaacag gaagagattt tcatttgatt tgtgaaagat
     6961 attttagcaa tatacctctt ggaatctatt ttaatgagga tgataaaaat agtaaaaagt
     7021 ttttaaagtg gatggaaaat ataaaaaaag ttgttcctat tgaaaaagga aaaacgtatt
     7081 tgccagaata tgaagtaagg atgacattaa atggggatat aatacaggca aagtatgatt
     7141 tagttgtaat tggaaataac aatatagaaa tatgggattg gaaaaccgag tctaaaaaga
     7201 ttgactataa acacgtagaa aatagaatac aaactattgt ttatatgttt ttagcaaaag
     7261 aagtaatacc taaagtttta aaaatggaca taaatgttaa agatataaat atgagatatt
     7321 atcaacctga atttgatgac ttaccaatta ccattttata tgatgaagaa aaacatgaag
     7381 caaatagaaa taaaattcaa aattatataa gtatgataaa aaacactaat tatgaagaac
     7441 atacatacga agacaatcta tacaatgata tagaaaaggt atataataaa gaagaacgta
     7501 tgtgctatag aaataaaaag cattgcaagt attgtgaatt taataagtta tgtaatggca
     7561 aagaaataga ttatagtatt ttggaggcgg aaatttatgg gacttaggtt tgtattaggt
     7621 agaagtggaa gtggaaaatc cacctatata ctagatgaga ttaaaaaaga agctcaaaaa
     7681 aatgaaacga catcaattat acttttagtt ccagaacagt acacatttga ggctgaaaat
     7741 agagtaagta aactattttt aggaaaagaa aaagataagt atctaagagt tagggtactt
     7801 agctttaaga cactaagtaa tatagttttt tcacaagtag gaggattgac agatgtaaat
     7861 ataaattcta gtggaaaagc aatgatggta tatagagcta ttgaagatgt aagtgaagaa
     7921 ttaaatgtat tttcaaaatc aaaatcgcag tctggttttg taagctcaat tacagatatg
     7981 atatcagaaa tgaaacaata caatataagc cctgaaatgt tagaaaatat atctggagaa
     8041 ttggataatg aaactttaag tttaaaatta aaagatataa gtaaaatata taattctttt
     8101 gaagggaaat tgcatgaaaa ttatgtagat gctcaagata tgttaacttc attggcaagt
     8161 aaaattgaat taagcagtta tttagatgga gcttgtgttt atatagatga atttacaggt
     8221 tttacaccaa atcagtacaa tgtcataaag agtatattaa ataagtctaa aagtgttaat
     8281 atctctttga ctgtagatga tatcaactat attgggtaca gtaaatctga tatgttttcc
     8341 agaacgaaat ttacttattc aaaattgact caattgtgca acgaagaagg cataaaaata
     8401 ttgccacaag taaatttaaa cacaggtgtt ataaaaagat ttgaaaaagt taaggaatta
     8461 cagcacttag aaagatttta taatgcttat ccatataaaa tatattcaaa tcaaactgaa
     8521 aatataaaga taaaagagtt taacaattta tattcagagg tggaagagat agccagagaa
     8581 attgtacatt tagttagaga taagaatgtc agatatagag atataaccat tgctacaaga
     8641 gatttaaata gatatgattt tttagtacac tctatattta atgaatataa tataccaaac
     8701 tttatagata agaagagaga ggcaaaaagt aatccaatag ttattttaat tatttcagct
     8761 ttagaaatga agaatagacg atatgggtat gaaactatgt ttaggtattt aaaaagtgga
     8821 cttataggaa ttgataatga tgatataaat ttactagaaa attatgtgtt ggctaatggg
     8881 attaaaggta aaaaatggtt tgatgaaaaa tgggattata gaataaccca aagtctttca
     8941 ggtcaagaaa gtgaatttga actggaatta aaagagaaaa taaatgaaat aaaaaataga
     9001 gtattagagc ctatagtaat tttacaagaa aaattaagag gaaaaaatag agtaaaagaa
     9061 atctgtagat atatatatga atttttatta gatataaata tgccagaaac tatagaaagt
     9121 ttaataataa attttaagga taaaggggaa cttgatgttg caaatcaata ctcacaagtt
     9181 tgggacatag tagtggacat attagaccaa atggtggaac ttatgggtga tgaaataatt
     9241 tctttagaaa aatttataaa attaataacc ttaggttttg atgaatatga attaggactg
     9301 gttcctccta gtatagacca ggtacttgta agtagtgtgg atagaatgaa aaatccagac
     9361 acgaaatatt tatacctagt tggaactact gatggtgtgt ttccgctgat tacaaaggat
     9421 agtggaatat tgagtgataa tgatagggaa agtcttggaa acaaaggaat cgaagttgat
     9481 attgatagta agactaggag ttttgaagaa cagtttcttg tatataaagc tcttacttcg
     9541 acatctaaga atttaaccat aacatatcca atatcagacc atgaaggtaa aacgcttaga
     9601 ccatcaataa ttatatcaag acttaagaag atatttccaa atatagaaaa taaaagttat
     9661 ttagtggaag aaaataaaag cactgataaa gatatactta aaaaaataac ggttaaatcc
     9721 cctacattta atgaacttat aaacgtaata aaaaattatg acagtgatgg ttacaataca
     9781 gaagagatta atagtatttg gttagatata tataggtact atttaaaaga tgaaatctac
     9841 agttctataa caaaaaaagt tataaaaggt cttagttata ctaatcaagt tcataagatt
     9901 gaagagaaaa aaataaggtc attgtataaa agtaattctc ttagcatatc taggcttgaa
     9961 aaatatgctg aatgtccatt tgcttatttt atacaatatg gtctaaaagc aaaaaagcgt
    10021 aaagagtatt catttacacc accagattta ggaactttta ttcataatat tttagatagg
    10081 ttttcaaaag aacttttaca agataattta acttggagag atattgatga aaaatatata
    10141 gaattaaaga taggtataat agttgatgaa ataattttaa agataccagg atatatatta
    10201 aatagttctg agaggtataa ataccttgca tatagattaa agaatatgtt gacaactgct
    10261 ataactataa ttagtcagca aataaaacaa ggttcatttg aaccaataga ttatgaagtt
    10321 aaatttggca acaatggaaa atatccacct ataaaaatgg tgttagaaaa tggacaagaa
    10381 gtaagtttaa ttggacaaat agatagagtt gatgaatttg aagaaggaga aaataaatat
    10441 ataagaataa tagattataa gtcaggcaat aagtccataa gtctaacaga aatatattat
    10501 ggtctacaat tacaattact tgtgtattta gatgcaatcc ttgaaagtgc aaaggatgaa
    10561 gatataaata taaatccagc tgcaatacta tattgtagaa taaataatcc aatagcaaaa
    10621 tttaatgaag ataaagatga tgaagaaata caagaagcaa tattaaaaga acttagaatg
    10681 aaggggcttg tagtaaaaga ctctcacata gttaaagaga tggataaatc attaatagat
    10741 ggagaaagga aaaactcttt agtaatacca gtaggtctta ctaaggatgg aaatgtaggt
    10801 aaaagtactt cagcaataag ctatgaggat ttcaaactgc ttagaaaata tgtaaggcat
    10861 gctataaagg atttatgtga agaaatgtta agtggagaaa tacgtatagc tccatataaa
    10921 cataaagatg gaacatcatg tgacttttgt gattactctg ctatatgtca gtttgattca
    10981 actataaaag ataacaagta taaaaattta aataataaga gtaatgaaga gataataaaa
    11041 atgatgaaag gagatgttaa ttagtgagtt ctcctaaatg gacaaaagag caattagaag
    11101 ttatagaaag tagagaatgc aatttattgg ttgctgctgc tgctggttca ggaaaaacag
    11161 ccgttctagt tgagcgtata attcaaatga taacaagtag agaaaatcca attgatatag
    11221 ataagttatt agttgttaca tttactaatg ctgctgcgtc agaaatgaga gagaggatag
    11281 gggatgctat aggaaaagcc ttagatgaaa acccagaaaa taaacattta caaaaccaac
    11341 ttgttttatt aaataaatct agtattacaa caatacactc attctgtttg gatgttataa
    11401 aatcaaactt tcatagaata aacttagacc ctaatttcag aataggagac caaactgaat
    11461 gtgctatttt gaaacaagaa gcaatagagg aagtatttga agatttatat gaagaaagag
    11521 atgaggggtt tttaaattta gttgaaagtt atgcagaaag aggaggagat aaagaagtac
    11581 aagatattat cttgggaata tattcatttg caatggcttc tcctgaacct aaaaaatggt
    11641 tgattgactc agcagaacga tttaatattg atgaaaattt tgatttttca cagtctattt
    11701 gggctagagc tatattagat actgtaaaaa tagagattaa tggtctttgt ctaaatatgg
    11761 aaagggcatt aaaagaagtg gaatcaatag aagaattaga aacttttgca gaaaagttat
    11821 ccgttgaata taaaaaaatt gctgacattt cacaagcatg taataaatct tgggatgagg
    11881 catataaaaa gatggcaagt atgtcctttg aaaattatgt aaaaggagta aaaagaattt
    11941 caaaagatgc tccttcgtat ataaaagaat caaaagaaaa ggcaaaaact ataagagata
    12001 agactaagaa gtctttagaa agtatagtaa gtgctacatt caataaagat aatgattcta
    12061 ttagagaaga aataaaatat ctttataaca tagttaaacc aatatctagt gttgtactga
    12121 gatttgaaga ggaatatagc aataagaaaa gagaaaaagg aataatagat tttaacgata
    12181 tagagcattt tgcattaaat atacttacag atgtagatga aaaaggtaat attgtacctt
    12241 ctgatatagc agttggatat agaaacaagt tttatgaaat atttatagat gaatatcagg
    12301 atagtaatct agtgcaggaa gtactgctta aagctgttgc aaatacagaa actccaaata
    12361 gatttatggt tggtgatgta aaacagagta tatatagatt tagacaagca aagccagaat
    12421 tatttttgca aaaatataat aactataatg ataaaaaggg aagctcccat agaaaaataa
    12481 tgctttacaa aaactttaga agtagagaag aagttgtaga tgctgtaaat tatatatttg
    12541 aaaatataat gaatgagaat ataggagaaa ttgaatatac agaaaaagaa agactaaatt
    12601 taggtgcaaa ttttaatgtg gatacagacg agaaatctat tattggtgga gcaacggaga
    12661 tacacctaat acaaaaagat aataaacttg atgatgatat tataaatgat aaagacgata
    12721 gaattaataa caaagaaaat gaaatagagg aagaagaaaa attagataat atacaacttg
    12781 aggctagaat ggttggaaac attatcaaag atttaatgaa agtcaatgaa gatggaaaaa
    12841 ttcaaaaggt ctatgataag ggaatagatg gatatagacc tgtggaattt agagatatag
    12901 ttattctttt aagagctaca tctgcatggg ctccagtgtt tgcagatgaa ttgatgaata
    12961 tggatatacc aacgtatgct gatgttggag tggggtattt tgatacgatt gaaataaaaa
    13021 caatattgtc attacttcaa ataatagata atccaatgca agatatacct cttatatctg
    13081 tattaaaatc acctatattt ggatttacac cagaggattt gattgatatt agagttcaga
    13141 gtaaagataa aattttttat gaggttttaa aaagtacagc agagtatgat ggatttacag
    13201 attctcaaaa tgaaaatgag tctgagttta taccaagtga agaatgcata aacaaaagta
    13261 aagatttttt aattaagcta aaggaattta aagaaaagtc aatgtacatg agtacagatg
    13321 aatttatatg gtacttgtac acaaggactg gatactatgc ctatgttgga gcattgccag
    13381 gtggaagtca aagacaagct aatttaaaag tattgtttga gagagcaaaa caatttgaag
    13441 aaaccagtct taaaggaata ttcaactttg taaattttat agagaaatta aaaaaatcta
    13501 gttctgatat gggaagtgca aaaacacttg gtgagaatgc aaatgttgtt agaataatga
    13561 gtattcataa aagtaaaggt ctagaatttc cagtagtcat atgctctgca atgggtaaaa
    13621 atttcaatac tcaagatttt aaaaagagta ttttatatca tcataattta gggtatggac
    13681 ctcaatttgt agactatgag agaaggattt cttttccaag tatagccaaa gaagcattaa
    13741 aaagcaaaat aaatatagaa aatttatcag aagagatgag agttttatat gttgcattta
    13801 caagagctaa agaaaaattg attataactg gttctactag aaatatacaa gatagtataa
    13861 agagatggtc aaatggaatt gaaagtttag atacaatatc acaatacgag atattaaaag
    13921 gtaaaaattt tttagattgg ataatgcctt gtgtattaag acatagggat ttatctaatc
    13981 tactagaaga agtaggatta gacgcagttt ttaatgttga acataattca aaatggtatg
    14041 gaaagttgtg gaataagagt gatattttag tggaaaagaa gagtgatgaa gaaaaagaaa
    14101 gtattgaaga aattcttgaa aaaatagatg tagataatcc tgatagtgat tattacagtg
    14161 aaatagaaga aaaattaaac tatatatatc catatgaatt tagtacaaga aaacctgcta
    14221 ctatatctgt tacagaaata aaaaagatac aaaataatta tgaagaagag ttaataaata
    14281 ctatatttga acaaaaagta atattaaaaa agcctctatt tattcaaaat gaagaagaaa
    14341 gagaaaaaat aagtggaaca gaaagaggta caatagtcca tttagttatg gaggttttag
    14401 acttaaaaaa tgtaagtagt gtaaatgata taaaatcaca aataagaggt tttgtttcaa
    14461 aaggtataat aacagaaaaa caagctagta tagtaaatcc atataaaata tataaatttt
    14521 ttgcctctaa cataggaaaa agaatgttga atgctgaaat tataaataga gaaaaatcaa
    14581 tttatgcaca agtaaatatg aaagacatat atatttatga aaagcttata aacaatgacg
    14641 ataaaaaact ttatgataat gaaagtgtca tgttaagagg tatagttgat gcttattttg
    14701 aagaagacaa tcaaatagtt ttggtggatt ataaaacaga ttttgtaaat gaggaaaata
    14761 taaatcaaat aatagagaaa tataaaaaac agttggattt atatgcagat attattgaaa
    14821 ctttaactgg taagtcagta aaagagaaat gtatatattt atttggagtt gatgaagctg
    14881 tttgttatta gtttttatat ataaattaaa cctaaaagat agaggaaggg gaaaaaatga
    14941 gatttattca tacatcagat tggcatctag ggaagtccct agaaggccat tctagaattg
    15001 aggaacaagc aaagttttgt gaggaattta taaaaatagt agaatcaaat gaaatagata
    15061 tggttataat tgctggagat gtatatgata cttctaatcc accagcacaa gcagaaaaac
    15121 tattttatca gactgtatca agacttgcca ataatggtca gaggtgtgta ttaataattt
    15181 caggaaatca tgataatcca gagagactct ctgcaataac acctctagca catgaacagg
    15241 ggatacttat atatggttat ccattaagtg ctacgataga agctaagtat aaagggtttg
    15301 aaataacata tgcaactcag ggatgtacaa aactgaatat aaatggagaa aatattgtgg
    15361 ttgctacatt accttatcca agtgaaaaaa gattaaatga agttttttca agtgaagatg
    15421 agtttgagaa acaaaaaaat tattctgaaa aggtaggaga tatatttaga agtttagaag
    15481 aaaattttag aagtgatact ataaatatag ccgtatcaca tatatttgta ataggtggag
    15541 agagtactga atcagaaaga cctatacaat taggtggaag ttttttagtt gaaagaaaag
    15601 atttgccaga aaaggctcaa tatactgcac taggtcattt acataaacaa caaaaagctt
    15661 ccgaacgttt aaatgcatac tattctggtt ctccacttca atatagcaag gatgaaagag
    15721 cgtataccaa aggggcatac atagtggata taaaagctgg tgaaaaacca ataattgaag
    15781 atgtatattt taataattac aaacctatag aagtatttaa atgtaatgga atagaagaag
    15841 cactagatat atgtgagcaa aatcaagata gagagatttg gtcatatttt gaaataaata
    15901 ctgatgagat aatatcacag aatgaaatta aaaaaatgaa ggaactatta aaagacataa
    15961 tagaaataaa accaataata acatcttgtt atgaacaaga aagtgtagat ataaaagaaa
    16021 agtctatggc agagttgttt agagagttct attcttttag taaaggtgta gagccaaaag
    16081 gagaacttat ggatttattt ctagatataa taagtgaaga aggtgaatca gcagatgaga
    16141 ccaattagat tagaacttac agggcttaat agctatattg ataaacaagt tatagacttt
    16201 gaaaaattaa ttgaaagagg tttgtttggg atatttggaa ctactggaag tggaaaatct
    16261 acaatcttag atgcaataac tattgctatg tatggaaata tatccagaaa tacaaaagaa
    16321 tatataaaca gtgtgtgcga taaggcaatt atatcatacg agtttgagat aggaagcaaa
    16381 aacactagaa gaagatacat tgtagataga accattgcta gaagcaaaac aggaacaaag
    16441 acctctaatg ctagattaat agaagtattg aatgacaata cccaaaatgt tttagctgat
    16501 aaagttgtgg aagtaaatga aaaagtagcg caggtcgtag gattaacggc aaatgatttt
    16561 actaggtcag tagttttacc acaagacaaa tttaatgagt ttctaagatt atcacgtgca
    16621 gatagaagag acatgttaga gagaattttt aatcttgaga aatatggaag aagtcttggc
    16681 gaaaaagtga aaaagagaaa aaatatacag ttacaaaatt taaaagattt gaaatcaaaa
    16741 ttaagtcaat atgatggaat tacagaggaa gtatataaca atataaacca agaattaata
    16801 gagttaaaaa atttggaaaa agataagaat aatgctttag acctagctca aaaatcttat
    16861 gaagaaagta aaacagtata tgaagaacaa ttaaagttag aaaaaaatga acttagaaaa
    16921 aatgagcttg atttaaaaaa tagtgagata aaagaaaaga ttgctcttgt agaaaatgat
    16981 agtaacgcta aaaaggtaga cccatacata agttcagttc aaaatctaga aaaaaagata
    17041 gatgaagata gcttcgcagt aagtaattta gaaaagaaat tagcaatatt aaatcaggag
    17101 cttgaagtta caaaaaatag atatgaaaaa ataaacaaaa ttaagaatga agaaatccct
    17161 aaattgagtg aagaaaaaat aagattgcaa caagcaataa aattagaaga agagttagtt
    17221 ttattagata gagagttaaa agagctaaaa gaaagtggaa ttaatttaaa taagactaaa
    17281 gttgaattag aaaaagtaaa gcaggtgtca gagtccagaa aagatgcagt tactaaatct
    17341 ataaaagaag ttgaaggaaa gattgataaa gtaaatataa gtgcagaatt aaaacaaaaa
    17401 atatttctag catatgaata cgagaaagat tacaacaacg tattggaaga aaaaaatcaa
    17461 aagctaaata aactagaaga aatactcaaa gagacagaaa atataaattt aaaagttaga
    17521 tatattgata aagataagaa tgatgtaaat cgtaatttag aaaatttatc acttcacttg
    17581 gatgttcttc ttaaaaaatg tcctggtaag agtgctgatt tacttttaaa atctgaatat
    17641 gttactgaat taagaaataa agcaaataat actaaagaaa atgaaattaa gaaaagcagt
    17701 atacaagatg aattaaagat aatacttgaa agtaagttta atactgaaag ggaagtaaat
    17761 ttactaaatg aaaaacttga aaataataga aagaacagag atgacttaga aaaagaatta
    17821 gaagaactaa agtatttaaa tttagcctct gaacttagac gtgaattaaa agaaaatatg
    17881 ccttgtccag tttgtgggtc aaaacatcat gaaaatcatg atataactaa gtatgatgaa
    17941 aatatatctt ttgtcaaaga aaaactggag aaattagaaa aagaaaaaat aagtataaga
    18001 aacaatatag aggaattaaa tgctaaagta agtgggtatt tatctataga aaaaatgaag
    18061 actaaagaac ttgaagatgt aaaaggaaaa ctagggggga ttccatctag tcaattatta
    18121 aaaaaacttg atgaagaaca aagaaaactt gcattgttaa aatctaatat tcaggagtgg
    18181 gagaaagaaa aagagagtac tgaaaataaa gtaacattag ctaaagaaga aaaaaataaa
    18241 attgaaaaag aagaattaaa aataagagag agtctgaata attataagaa attaacaaga
    18301 gatttaaaca tagaaataga aggtttagaa aataaatgta aaaaacttaa acaggaatac
    18361 ctaggattaa agacgattac taaagtctct aatctattgt caaaagtaaa agaaataagg
    18421 gagaatgaaa aagaattaga attactaagt actgggcatt caaatttatt aaaaaataga
    18481 gactcactag atattaaaat aagagaaaat gagagtaaac tacatgaaat agagatagaa
    18541 ttaataaagg ctagagaatt atatgtagaa aagaaattga gtagagataa taagtataaa
    18601 gaagttatta gcataacgaa aggtgattta gctaaaaatc ttttacataa tgttgaagaa
    18661 aatatatgta agatattaga acaagaagaa tcaagtaaga aaaaattgga agagcaaaga
    18721 ttagaatatg aaaaaaacat tgctgaaaag cacaatatag atggtagact taaaactgct
    18781 aaggaacaat ataaagacca aaaatcaaca ctaaataaac tattggcaga aaataaattt
    18841 gaaagtatat atgcagtaaa aagagcttta ttagatactg atgcagtaaa aaaattgatt
    18901 gaagaaatac tagagcatga agaagaacaa aagttattat catttaaaat aaaatcatca
    18961 aaagaaaaat taaatggaag aagcataaag aaggagtact ttgaacagtt aaaagatgaa
    19021 atttataatt tgaaagtaga aataggaaat atatccaaag atattggagc taatcaaaat
    19081 cagttaataa cattaaaaga ctctttagat aagataaatg attttaataa acaacttaag
    19141 gtagttgaac acaatgtgga cttattggaa gaattagata aatgtgtaca aggaaataaa
    19201 tttgtagaat atgtttctac aaaccaatta aaatatatag cgttggaagc atcaaaacga
    19261 ttggatggaa taacaaaagg aagatatgca cttgaaattg actcaacact aaactttgta
    19321 atgagagata actttaatgg aggagaaaga agaagcattg atactctatc tggtggagag
    19381 acattcttga catctctatc attagcactt gctctttcat ctcaaataca attaaaggga
    19441 agtgcaccat tagaattttt ctttttagat gaaggttttg gttcattaga tagtgaactt
    19501 ttagaaattg ttatagaatc cttggaaaga ttgcatagta ataatctaag tgtgggtata
    19561 ataagtcatg tcgaggaact taaaaataga gttcctgtta agctattagt ttcatctagt
    19621 gaggctggaa taggttcaaa agtaaaaatt gaatatagtt agaaaatata tgttaattga
    19681 atatattatc taatatttcc aaataatatg taattgtgat ataataaaaa ctaatattaa
    19741 agttatttat aattaatatt aatataaaaa catgtaagta ggagtgtggt aagtgttgga
    19801 atcgcccaat aatttgattc agattatttt tttaatagta ttacttatag ggtctgcatt
    19861 tttctcagca tctgaaacgg ccttaatgtc gttgagtaaa atcagaatca gatatatgca
    19921 agatgaagga gttaaaggag ctaagttagt aagttcatta atagaaaatc caaataagct
    19981 tttaagttct atattggttg gaaataacgt cgtaaatata gcagcaacat ccatatcaac
    20041 atctttgttt ataggattaa tgggagaaaa aggagtggca cttgctacag ctgttatgac
    20101 agtattagta ttaatatttg gtgagattac tccaaaaaca atagcagcaa ataattcaga
    20161 aaaggtttct ctattagtat ctaaacctat aaaagcaatt atatttatat taagaccaat
    20221 agtatggata tttaatataa ttacaaatat tatatttaaa ttatttggta taacaaataa
    20281 aggagctaaa tcattcataa ctgaagaaga gctaaaaact atggtaaatg taagtcatga
    20341 agaaggcgtc cttgaaatgg aagagagaga aatcataaat aatgtttttg aatttggaga
    20401 tatgcaagct aaaaatgcaa tggtacaaag aatagatatg gtagctatag atatggaaga
    20461 tagttatgat gagataatac aggtatttaa aactgaaaaa ttaagtagaa tgcctgtgta
    20521 tgaagaaact atagatgata ttgtaggaat acttaatata aaagatatta tatttttatc
    20581 tgatgaagaa atagagtcat ttgatattaa aaattatatg agagaacctt ttttcacgta
    20641 tgagttcaaa aagataacac aacttcttga agagatgaaa cttgaaaaaa gtcagatggc
    20701 tatagttgta gatgagtatg gtggaacatc tggactttta actatagaag atttagtaga
    20761 agtcattgtt ggagatatag aggatgaata tgatgaagaa gaggatgaaa tacaagttat
    20821 aaaagaagat gagtatattg tagatggaag tactaaaatt ggtgatgtta atgaacttat
    20881 tggtgtaaac ttggaatctg aggagtttga ttccatagga ggttttataa ttggacacct
    20941 aagcagattg ccagaagaaa atgaagtaat tgaagttgat aatataagat tttgtataga
    21001 aagtatagaa aaaaatagaa ttaaaaaaat aagaatatat acataatgta ataatgttct
    21061 taaatttatt agaagtgtat aaatataaaa gatatctttt atatttatac acttcttttt
    21121 attttgtatt caaataaaac tagtatgaaa tggacaaaat aaaaatataa attagaagaa
    21181 aggagatttt taagatgagc atactagaaa ataatttttt atacaaatta aaaaacaaca
    21241 ctatcttttt ttgtatatat acattgttat ttatttttat ttacaaagcg tttccataca
    21301 tagctccatt ttttctaggt gctataatag cacttatgat taatcctata tcacaaaagt
    21361 tagaaaataa gtttcatata aataaaggta tctctactct tgttctaagt tttcttgcag
    21421 tggctatagt cagtacagtt actacaataa tagtaataaa ttcaatgaaa gaattaatgg
    21481 gatttttaaa taatatatct gctaatcctg aggatataag taatactatt atgtattttt
    21541 taaataaaat aaatgacttt atgaaatcat ttcaagaaat agccaatttt gatgtagaac
    21601 aattagtaaa caaattcagt ggtgaagtaa tgcaaattac aaaaaatctt cttactagta
    21661 tacttggatt ggctacttct attccatata ttataatatt tataattacc ttgtttattg
    21721 ctacgtattt tatagcaaaa gaccttgata agattgaaaa tagtttttat aatatgttta
    21781 ctgttgatgt tagaaagaag gtaaaaaacg taaagaaaga ggcagggctt tcacttgttg
    21841 gatatataag ggcctataca atacttatgg ctataacatt ttttgcaatc tggggaagtt
    21901 ttgctttatt tggattgaaa tacggtctaa tagtagggtt tgtaggagct ttaatggatt
    21961 taattccatt cctaggtata ataacaatat atcttccagt aattgtttat tattttctta
    22021 taaaaaatta ttttatagct ataagtatga ctgtgatatt ttttgttttg tctttgatta
    22081 gagaaatact tgaacctaaa ctagtatcag taaatgttgg actaaatcca ttagctaccc
    22141 tagcagcgat ttttattgga atccaagtaa aaggaataat tggagtaatt ttttgtttgg
    22201 gtttggtatg tatgcatgat atacttaaga aggtggatat tttttaatta taataattga
    22261 tagatttttt aaaaataaaa ttttattcac aggtaaataa aaaaatatta atcttattaa
    22321 gaaagagggt atatacgtga aacaaaaagt agtggaaaga tttttaaaat atgtatcatt
    22381 tgatacaaca tctaattctc agtgtgagaa ctgtccatct tcagaaggtc aaagagtttt
    22441 agctaagtat atagttgaag agctaaaaac aatgggtgtt gatgatgtga gtttagatga
    22501 aaatagttat ataatggcta ctttaaaagg aaatactgat ggtgtggata ctataggatt
    22561 catatcacat ttagatacaa ttgaagatgt tagtggaaaa gatattaaac caaaaataat
    22621 agaaaattat gacggaaaag acatagtttt aaatgaagcg ttaaatgtta ttacgtatgt
    22681 aaaggattct ccagagttgg aagaatttaa aggtgacgat ttaatagtca ctgatggaac
    22741 aactctactt gggtctgatg ataaagctgg tatagctgag atagtgactg caatagagta
    22801 tctaataaat catccagaaa ttaaacatgg agatataaaa ataggattta caccagatga
    22861 agaaattggt agaggtgctg atttatttga tgttgaaaaa tttggagcaa aatatgcata
    22921 tactttagat ggaggaatag ttggagaact tgaatgtgaa aattttaatg ctgcaaatgc
    22981 aactattact atacatggta gaaatgttca tccaggttca gctaaaaata aaatggtaaa
    23041 tgctatacat atagctgctg aaatatcaga aatgttccca gcagatgaaa gaccagaaac
    23101 aacagaagga tatgaaggat tttggcattt aaattctata ggtggaaatg tcgagaatgt
    23161 aagtatggct tatattatta gagaccattg taaagaaaaa tttgaaaata gaaaatctat
    23221 tatgatagag aatatagaaa aaataaataa gaaatacgat aatagagtgg aattggattt
    23281 aaaagactct tattacaata tgaaagaaaa gattgagcca gttatgttta tagttgatat
    23341 agctaaagaa gctatggagg aattaggtat aaaaccacgt ttagttcctg taagaggtgg
    23401 tactgatgga gcaagattat cttttaatgg attaccttgt ccaaatatat ttactggtgg
    23461 attaaacttc catgggaaaa atgagtgtat accagttagt tctatggaga aagctactaa
    23521 actaattgta agaatagctg aaaaatatgc tgaaagagtt tagttaaaaa gtatttaaaa
    23581 attaagcatt taaagttata atagctatat cattctttat aagtcaagct gattataagc
    23641 ttgtgttgta cttaaaatgg tatagctatt tttgtaatta tttttataaa agataattat
    23701 ttttagttta gggtatcaat aaaaagtatg aatatcaata ggtattaaca tttaaaaggg
    23761 ggaattgtat tgaaaattaa atctaaaaaa ataatagcat ttgcactttc acttgggatt
    23821 atgttgccaa gttgtgtata tgcagacaat attagtaaaa atcaaaatgc acaggtagat
    23881 atgaacaatt atcttcaagg tagaaaatct ccaaaggagg aaaaacttat tggtgaagat
    23941 agatttgata cagcgataaa aatatctcaa agtggttgga ataatggttc agaaagggtg
    24001 tttctagtta actcaaattc attgccagat gcattggctt caactccttt ggcaagtaaa
    24061 ttggatgcac caatactgct tacaaataaa aatagtatac catataatgt aacagaggaa
    24121 ataaaaaggc ttaatccagc agaagttatt ttaattggaa gtgaaggagc tatttcatca
    24181 agtgtaaaag aatctcttga agatatggaa gtattagtca gtagaatcgg tggagcagat
    24241 agagaagaaa catctttact tcttactaga cagctagatg atactggtga tttaggtgtc
    24301 tcaaaagtgg cagtggttaa tgggtataat ggactggcag atgcaacttc aatatcaagc
    24361 ccagctgcaa gtgataatac agctataata tatacaggta aggatagcat aagaagtgag
    24421 gcaaagaatt ttattacaca aaactcaact aagacataca tagtaggtgg ggagtacagt
    24481 ataagtaaaa aacttgaagg acagttagta aactcagaaa gactagcagg gacagataga
    24541 aaagatacta atgcgaaagt tttagaaaag ttttatggaa aatcaagtaa ggttaataat
    24601 atgtattttg caaaagatgg aagtggtaga gaagctgatt tagttgatgg gcttgctgct
    24661 ggagtattag catcaaaaac aaagtcacct gtagtacttg caagtggaag tttaagtagt
    24721 gcacagaaaa gttttataaa aaaagtaaag gctgataaat ttgtacaagt tggtggaggt
    24781 aaaaatagta aaccatatgc agaagcatta gccttacagt aatattgtgt aaatcaaaat
    24841 taatatataa taatagcaag taaaccaagt tgcactttaa tatatataat aaaataagta
    24901 aactaagtta tatttcagta taatatataa taaaataagt aaactaagtt atatttcagt
    24961 ataatatata atgaaataag taaactaagt tatatttcag tataatatat aatgaaataa
    25021 gtaaactaaa ttatactcca atataatata taatagaaac aagtaaacta agttatattt
    25081 caatatagca tataataaaa caagtaaacc agattctatt taattagaag tttaaggtat
    25141 tgtacttaaa cttctaattg agatagaaat aaaatggttt acttgtcttt attatgaatt
    25201 taataaatta aagcttattt tatttttatt aaaaatttac taatcattga tatttattat
    25261 atttccagta ttgatgtcaa ttaagtttat atcaagttca agctcatcct catcatcagt
    25321 ttttatgata tctataattg cgacagaatg gcttccatct tttgggatag aagtacttcc
    25381 tggatttatt actattaaat tatcatccat gtatagtttt tttacatgag tatgtcctaa
    25441 aactaatatg tcaccaccca ttttctttgc tttgtcaata atttcttctt ctgattctat
    25501 ataaccatga ttcaatataa ttctaatttc accaaattgg ctcatgacat aaggactctg
    25561 aataggatgt tctataacca tctggtcaac atctgcatca cagttccctt ttacaatcac
    25621 aatgttttct aatttattta atgtctcaat aaatttttta ggattatatc cttctggaat
    25681 atcatttcta ggtccatgat ataagacatc tccaccatgt aataaaacat cacaatcaga
    25741 taatacattt aacgcttttt caaagtaaag taagctacca tgagtatcac tcattattcc
    25801 tattttcata ttaaaaatcc tcctaagtac agtctataaa aatttttcag atactctatg
    25861 ccaaaactca tagtttgaca ttctaagtaa ttttattttt gcatcagata tactaacttt
    25921 tatattttcg atttgtctaa atctgtgctc aactccatca acgacaatca atacagaatc
    25981 ttcaaatcta tattctggtg caatctttat aacagattca tttgaacata ttatacttga
    26041 tgtaaagcac ctatatgcat tggtatttat cggatgtaaa ggtgtaatct gcataagttc
    26101 aagatttata tcaacaatac tacctccagc agaatagtta taggctgttg aacctgtgga
    26161 agtagaaata atcataccat ctccactaaa attttgtata tgtttattat caaggcttaa
    26221 atttaggtgt atagtcctag acttgtctcc tcttataaca acctcattta cagcaagcat
    26281 attagaacca ctagtagttg tatatacttc cgcattaaga agtgacattt cttgaataat
    26341 ataatctttt tttgtataag cttcaataaa gctatcaatc ttatctggta aaatatcagg
    26401 aaaaaacccc agatgacctg tatttattcc cattatggga atctcaggaa aatcgaaatc
    26461 tctaactgtt cttaaaaaag agccatcacc accaattgat ataataagct ctgtgtctgg
    26521 ataaatatct gaatacactt caaagccagc attgataagt tttctagtta agagttcttt
    26581 agtctcaagg gacttattta attggtttgt atttatagtt ataattcttt tcatatattc
    26641 acctcttcat actttgtatt ataacatagt tttataattc ttaatttata aatttataaa
    26701 tgacctttgt agtgaatgtg ttaaaatatg tataggtggg tataaaaaaa tgcataagag
    26761 gtgaagatgt gtttagcata aggaatatca caaaaaaatt aggaaaattc aagttaaata
    26821 atataaactt agagttaaag gaaggggata ttgttgggat tataggacca aatggttcgg
    26881 gaaaaacgac tttaataaaa attataatgg ggattattga tgcagatgaa ggtgaaattg
    26941 aactttgtaa tgaaactatt gaaaattctc caataagctt taaaaacaat attggttttg
    27001 tatatgattc tttacaattt tatccgcatt taaaggttaa ggaatttaga aaaatagttt
    27061 ctttatttta taagaatttt gatagagaaa ggtttgatga ataccttaat aagtttgata
    27121 tagaagaaaa tatgcatatt gaaaatttat ctaaaggtca atctgaaaag cttatgttat
    27181 caagtgcact tagtcacaat gctaagttat tgattttgga tgaaccaact gctgggatag
    27241 acccaattgt aagaactgaa ataatgcagt acttacaaga ttttgtgaaa aatggaagta
    27301 gtagtgtaat aatttctact cataatactg ataatttaat taaaattgct gattatcttg
    27361 tttttataaa tagaggaaat cagattttta ctgttaagaa agaattaata gaacaagaat
    27421 ataagataat tagggcaaat aaagcagagt tagaagcaat taaagaaagc atagttggtg
    27481 tgaaagagta taaatattat aatgaggcac ttgttaaagt tggagatagc ttgaaagtaa
    27541 aaagcctatt gatagaaatt gataagcata aggtcaaaaa tcctactata gaagaactaa
    27601 tgtattatta tgtaaatgag gtgagatgat gttcaattta ataagaaaag atttaataat
    27661 agggattagt tcagatggta tccgtaattt aaagtacata ttgctatttt ttgtgtttta
    27721 ttttttcctt aattcaattt catattatac agtaagtatt gttgttagtt atttgatatt
    27781 tataaatacg tttgagtgtg attatgaaaa tgattcaagg atttttataa ggagtatgcc
    27841 agttagtata gaagatatag tttactcaaa atatttatta ggtgtaggat taataatttc
    27901 tgtaacaata attgtgtcct tactaagtaa attgacatca ctagtgttct ttagaaatat
    27961 ggttttaaat gatgtatttt tttctgtaaa tatattttta gcaattttga cgattttact
    28021 gcctttaatt tttaagtttg gatatggaaa aatgaaagtt tgtggtttta tagtaagtat
    28081 tttaatttac tttgtatatg gaagtctttt gaagatgatt agtatgattg tatatcaagt
    28141 aaagcatttt aattatagta aagttggagg agtatatctt tcaaattatg taactgatat
    28201 agctaatact aagtatataa atttatatag tatgacattt ttaacaataa taatttttat
    28261 aatatcaatg tatttttcta ttaagatttc aaaaaagaat aagtttaatt attaaaattt
    28321 tgattaatat tatagcacaa tagcacaaaa tataaggaga ctaaaaatga agaagtttat
    28381 aaaagtttca ttttttattt tggggatttt tacactattc atagctataa ataaattagt
    28441 atatagagat atggtaagtg tcaaagatta tgaaataaat catttagagg aaattgtttt
    28501 tgattttgat agcaggagaa gtagagatgt tggtactatt gtaagattta aaataagcaa
    28561 taatagtaaa tatagttata aattaaacag tgctaaaatg aagtttgaaa attgtgtgga
    28621 aaataaaaag ggaatgaata agtgttctgc atatgtaaat gtagatttat ttaatgaaaa
    28681 aaattctata actgaaagaa ctctgaaata tggaataaaa ccaaataatc aaggttatgt
    28741 tgattttgta attccaaaag gactaaattt tgattatagg tactttaatg aatctggtat
    28801 gagtgtagag tataaaggag aatatattgt caatattcca atggcaaaag gactttatct
    28861 agtagttgga aaaaataatg atacatggaa tgctaatatc atggaataat ttgaaaaata
    28921 aatcaattat agatataatt aagaataata tgaaatttat aaaagttcag actaggaggg
    28981 atatttaatg tcaataagta atgtaagaga gtattttaaa caatttggca aggaagacag
    29041 tatattagaa tttgaacaat ctagtgctac tgtggaactt gcagctgaag cagctggggt
    29101 tattccagca agaatagcta agacactctc atttaaaata ggagatgatg caattttaat
    29161 tgtgacagct ggtgatgcta agattgataa taagaagtat aaggctgaat ttaattgtaa
    29221 ggctaaaatg ttgacaccag aagaagtctt ggagtttact ggacatgcta ttggtggagt
    29281 ctgtccattt ggtttaaaaa attctataaa agtctattta gatgattcaa tgaaaagatt
    29341 tgatacagta tttcctgcat gtggcagtag taactctgca atagaactta catgtgaaga
    29401 aatggagaag ttttctaagt gtgaaaaatg ggtagatgtt tgtaagaatt ggtaaaaaaa
    29461 tatagtaaac tatagtagga attagtaaaa aactacctct gtatacaatc tatacagagg
    29521 tagttttttt gtgtaaatat ttataaatct aagaggaaaa tctaatttaa actaataatc
    29581 caaaataaag ttaaaaaatt ctgatttttt ttcgaaacaa taaaaaaatg acaaaaaagt
    29641 ggaaaaaatg taataaatat tgttaaaaaa ataattagaa attattgaaa aattatcctt
    29701 tgagtgatac tattatagat gtaagatatt taaaaataaa aaatagtcag ataaaaatac
    29761 gattatttag ctctattaaa ataattttta tacgataaaa atcttctgta catggctaaa
    29821 aaacagatgt acagacaata tttaatgttt aatataccct aatataaata tcgtaaacaa
    29881 attattttat ctgtaaccag tgtgaaagaa atcttattct aacttgaaat ttcacaaaat
    29941 tccaaaaagc gagatttttt ttaagtatag ttgattttaa attaacaatt tatgattaaa
    30001 ttaatgtcat aattggttag tataatcaca tataaatata gagcgtagtt tgattaaggt
    30061 tataaatttc tcgacgtata ttcaaatacc ttattataga tgttgccgag attttaatta
    30121 ataaatgaaa ataaaatatt tataaaatac tgaggaggct attatggatt taaattctaa
    30181 aaaatatcag atgcttaaag agctatatgt aagcttcgct gaaaatgaag ttaaaccttt
    30241 agcaacagaa cttgatgaag aagaaagatt tccttatgaa acagtggaaa aaatggcaaa
    30301 agcaggaatg atgggtatac catatccaaa agaatatggt ggagaaggtg gagacactgt
    30361 aggatatata atggcagttg aagaattgtc tagagtttgt ggtactacag gagttatatt
    30421 atcagctcat acatctcttg gctcatggcc tatatatcaa tatggtaatg aagaacaaaa
    30481 acaaaaattc ttaagaccac tagcaagtgg agaaaaatta ggagcatttg gtcttactga
    30541 gcctaatgct ggtacagatg cgtctggcca acaaacaact gctgttttag acggggatga
    30601 atacatactt aatggctcaa aaatatttat aacaaacgca atagctggtg acatatatgt
    30661 agtaatggca atgactgata aatctaaggg gaacaaagga atatcagcat ttatagttga
    30721 aaaaggaact cctgggttta gctttggagt taaagaaaag aaaatgggta taagaggttc
    30781 agctacgagt gaattaatat ttgaggattg cagaatacct aaagaaaatt tacttggaaa
    30841 agaaggtcaa ggatttaaga tagcaatgtc tactcttgat ggtggtagaa ttggtatagc
    30901 tgcacaagct ttaggtttag cacaaggtgc tcttgatgaa actgttaaat atgtaaaaga
    30961 aagagtacaa tttggtagac cattatcaaa attccaaaat acacaattcc aattagctga
    31021 tatggaagtt aaggtacaag cggctagaca ccttgtatat caagcagcta taaataaaga
    31081 cttaggaaaa ccttatggag tagaagcagc aatggcaaaa ttatttgcag ctgaaacagc
    31141 tatggaagtt actacaaaag ctgtacaact tcatggagga tatggataca ctcgtgacta
    31201 tccagtagaa agaatgatga gagatgctaa gataactgaa atatatgaag gaactagtga
    31261 agttcaaaga atggttattt caggaaaatt attaaaatag ataaatatta aaatatacac
    31321 aataggtcga tattaaaata gatatggagg aaggatttat gaatatagtc gtttgtataa
    31381 aacaagttcc agatacaaca gaagttaaac tagatcctaa tacaggtact ttaattagag
    31441 atggagtacc aagtataata aaccctgatg ataaagcagg tttagaagaa gctataaaat
    31501 taaaagaaga aatgggtgct catgtaactg ttataacaat gggacctcct caagcagata
    31561 tggctttaaa agaagcttta gcaatgggtg cagatagagg tatattatta acagatagag
    31621 catttgcagg tgctgatact tgggcaactt catcagcatt agcaggagca ttaaaaaata
    31681 tagattttga tattataata gctggaagac aggcgataga tggagatact gcacaagttg
    31741 gacctcaaat agctgaacat ttaaatcttc catcaataac atatgctgaa gaaataaaaa
    31801 ctgaaggtga atatgtatta gtaaaaagac aatttgaaga ttgttgccat gacttaaaag
    31861 ttaaaatgcc atgccttata acaactctta aagatatgaa cacaccaaga tacatgaaag
    31921 ttggaagaat atatgatgct ttcgaaaatg atgtagtaga aacatggact gtaaaagata
    31981 tagaagttga cccttctaat ttaggtctta aaggttctcc aactagtgta tttaaatcat
    32041 ttacaaaatc agttaaacca gctggtacaa tatacaatga agatgcgaaa acatcagctg
    32101 gaattatcat agataaatta aaagagaagt atatcatata atttaagggg ggataaagaa
    32161 tgggtaacgt tttagtagta atagaacaaa gagaaaatgt aattcaaact gtttctttag
    32221 aattactagg aaaggctaca gaaatagcaa aagattatga tacaaaagtt tctgcattac
    32281 ttttaggtag taaggtagaa ggtttaatag atacattagc acactatggt gcagatgagg
    32341 taatagtagt agatgatgaa gctttagcag tgtatacaac tgaaccatat acaaaagcag
    32401 cttatgaagc aataaaagca gctgacccta tagttgtatt atttggtgca acttcaatag
    32461 gtagagattt agcgcctaga gtttctgcta gaatacatac aggtcttact gctgactgta
    32521 caggtcttgc agtagctgaa gatacaaaat tattattaat gacaagacct gcctttggtg
    32581 gaaatataat ggcaacaata gtttgtaaag atttcagacc tcaaatgtct acagttagac
    32641 caggggttat gaagaaaaat gaacctgatg aaactaaaga agctgtaatt aaccgtttca
    32701 aggtagaatt taatgatgct gataaattag ttcaagttgt acaagtaata aaagaagcta
    32761 aaaaacaagt taaaatagaa gatgctaaga tattagtttc tgctggacgt ggaatgggtg
    32821 gaaaagaaaa cttagacata ctttatgaat tagctgaaat tataggtgga gaagtttctg
    32881 gctctcgtgc cactatagat gcaggttggt tagataaagc aagacaagtt ggtcaaactg
    32941 gtaaaactgt aagaccagac ctttatatag catgtggtat atctggagca atacaacata
    33001 tagctggtat ggaagatgct gagtttatag ttgctataaa taaaaatcca gaagctccaa
    33061 tatttaaata tgctgatgtt ggtatagttg gagatgttca taaagtgctt ccagaactta
    33121 tcagtcagtt aagtgttgca aaagaaaaag gtgaagtttt agctaactaa tttcttgggg
    33181 agggtattat gagtacaagt gatgttaaag tttatgagaa tgtagctgtt gaagtagatg
    33241 gaaatatatg tacagtgaaa atgaatagac ctaaagccct taatgcaata aattcaaaga
    33301 ctttagaaga actttatgaa gtatttgtag atattaataa tgatgaaact attgatgttg
    33361 taatattgac aggggaagga aaggcatttg tagctggagc agatattgca tacatgaaag
    33421 atttagatgc tgtagctgct aaagatttta gtatcttagg agcaaaagct tttggagaaa
    33481 tagaaaatag taaaaaagta gtgatagctg ctgtaaacgg atttgcttta ggtggaggat
    33541 gtgaacttgc aatggcatgt gatataagaa ttgcatctgc taaagctaaa tttggtcagc
    33601 cagaagtaac tcttggaata actccaggat atggaggaac tcaaaggctt acaagattgg
    33661 ttggaatggc aaaagcaaaa gaattaatct ttacaggtca agttataaaa gctgatgaag
    33721 ctgaaaaaat agggctagta aatagagtcg ttgagccaga cattttaata gaagaagttg
    33781 agaaattagc taagataata gctaaaaatg ctcagcttgc agttagatac tctaaagaag
    33841 caatacaact tggtgctcaa actgatataa atactggaat agatatagaa tctaatttat
    33901 ttggtctttg tttttcaact aaagaccaaa aagaaggaat gtcagctttc gttgaaaaga
    33961 gagaagctaa ctttataaaa gggtaaaaat ctaattaaaa atatatttgc tgttaactag
    34021 attaaatagt attttaatct agttaacaga atataaatac taaaataaca ggaggttata
    34081 actatgaaat tagctgtaat aggtagtgga actatgggaa gtggtattgt acaaactttt
    34141 gcaagttgtg gacatgatgt atgtttaaag agtagaactc aaggtgctat agataaatgt
    34201 ttagctttat tagataaaaa tttaactaag ttagttacta agggaaaaat ggatgaagct
    34261 acaaaagcag aaatattaag tcatgttagt tcaactacta actatgaaga tttaaaagat
    34321 atggatttaa taatagaagc atctgtagaa gacatgaata taaagaaaga tgttttcaag
    34381 ttactagatg aattatgtaa agaagatact atcttggcaa caaatacttc atcattatct
    34441 ataacagaaa tagcttcttc tactaagaga ccagataaag ttataggaat gcatttcttt
    34501 aatccagttc ctatgatgaa attagttgaa gttataagtg gtcagttaac atcaaaagtt
    34561 acttttgata cagtatttga attatctaag agtatcaata aagtaccagt agatgtatct
    34621 gaatctcctg gatttgtagt aaatagaata cttataccta tgataaatga agctgttggt
    34681 atatatgcag atggtgttgc aagtaaagaa gaaatagatg aagctatgaa attaggagca
    34741 aaccatccaa tgggaccact agcattaggt gatttaattg gattagatgt tgttttagct
    34801 ataatgaacg ttttatatac tgagtttgga gatactaaat atagacctca tccactttta
    34861 gctaaaatgg ttagagctaa tcaattagga agaaaaacta agataggatt ctatgattat
    34921 aataaataag aatttgggaa ttaaaagttt aaataaaatt gtttaaaaaa caatttcgga
    34981 tatatgaaaa atctaattta atgggggtaa tgaatatgag agaagtagta attgccagtg
    35041 cagctagaac agcagtagga agttttggag gagcatttaa atcagtttca gcggtagagt
    35101 taggggtaac agcagctaaa gaagctataa aaagagctaa cataactcca gatatgatag
    35161 atgaatctct tttaggggga gtacttacag caggtcttgg acaaaatata gcaagacaaa
    35221 tagcattagg agcaggaata ccagtagaaa aaccagctat gactataaat atagtttgtg
    35281 gttctggatt aagatctgtt tcaatggcat ctcaacttat agcattaggt gatgctgata
    35341 taatgttagt tggtggagct gaaaacatga gtatgtctcc ttatttagta ccaagtgcga
    35401 gatatggtgc aagaatgggt gatgctgctt ttgttgattc aatgataaaa gatggattat
    35461 cagacatatt taataactat cacatgggta ttactgctga aaacatagca gagcaatgga
    35521 atataactag agaagaacaa gatgaattag ctcttgcaag tcaaaataaa gctgaaaaag
    35581 ctcaagctga aggaaaattt gatgaagaaa tagttcctgt tgttataaaa ggaagaaaag
    35641 gtgacactgt agtagataaa gatgaatata ttaagcctgg cactacaatg gagaaacttg
    35701 ctaagttaag acctgcattt aaaaaagatg gaacagttac tgctggtaat gcatcaggaa
    35761 taaatgatgg tgctgctatg ctagtagtaa tggctaaaga aaaagctgaa gaactaggaa
    35821 tagagcctct tgcaactata gtttcttatg gaacagctgg tgttgaccct aaaataatgg
    35881 gatatggacc agttccagca actaaaaaag ctttagaagc tgctaatatg actattgaag
    35941 atatagattt agttgaagct aatgaggcat ttgctgccca atctgtagct gtaataagag
    36001 acttaaatat agatatgaac aaagttaatg ttaatggtgg agcaatagct ataggacatc
    36061 caataggatg ctcaggagca agaatactta ctacactttt atatgaaatg aagagaagag
    36121 atgctaaaac tggtcttgct acactttgta taggtggagg aatgggaact actttaatag
    36181 ttaagagata gttttagatt ataatattta caaattaaat atttaattat gaatttaacc
    36241 tgtaagaata actatttgtt attcttacag gtttttatag ttaaaaataa ttattatcta
    36301 ttaaacaaaa atagtgtaaa atatataata tcatgatttt gaagatataa aaaagtagga
    36361 agatataaaa gaaagtaggt aaaagtttgt ttaaaaaaga gaatcaaaga tataatctta
    36421 tatcgtatac aaatgaagaa gaaatgactt taaaagaagt tttattggac aagctaaatt
    36481 tctcagttag gtcattatca aaaatgaaga gggaaaagag tgttttagta aatggagtat
    36541 ataaaaaacc gagtttaaag gtgtatagtg gtgatttaat agaagtaaaa atagacgagg
    36601 aaaaagcaaa ttttgaacct caagatttaa atttacagat aatttatgat gattttgata
    36661 taattatggt gaataaacct ccgtttatgg tagttcaccc aacaaaaagc cactatgata
    36721 aaacaatagc aaatggtatt agttactata tagataatca aaaagaaaat gtaaaaataa
    36781 gatttgtaaa taggttagat atgaatactt cagggttagt tatagtagca aaaaatgctt
    36841 atgcacatca tactttgtct acagcaatga gtgaaaataa agttgaaaaa aagtatataa
    36901 cagtagttga tggaattata aaagaaaatg agggaactat agatgagcca atttatagac
    36961 ctacagaaga ttcaataaag aggataatag atgaaagagg acagtcatct gttactcact
    37021 ataaagtaat agaaagacta gaaaatgcaa ctgtattaga agtaagctta gaaactggta
    37081 gaacacatca aataagagta catatggctc atataggtca tggaataata ggtgatgagt
    37141 tgtatggtta tgtagatgaa gatctaataa ataggcaagc acttcatgca tataagctag
    37201 agtttgaaca accaagaaca aaagaaaaat tgaaatttaa agcagatata ccagaggata
    37261 tgaaagagtt aatatcgaaa ttaagataat ggggtgatat atatgataat acataaattt
    37321 ataatacatg ttttggacaa aaatagtgat gttccaatat taaatgactt tgaaggcaaa
    37381 gttaatcaag aagtagatgg ttttttccag aaagctataa aaagaattgc aaaagatgag
    37441 gatttaagaa aaggtgtttt taaagattat aatgacaatt taattaaaaa ctgttgtgaa
    37501 caaataatat atgatgaaag tacttttttg aaaaattcta aagaaattgc atcttacttg
    37561 tttgatgtta tgaaaattaa tgctgcacta gaatcttgtg atttggcaat ttgcttatac
    37621 actattaaag atgaaaagag tgtagcaata ctgaaattag attataaaaa gttgtacact
    37681 cattcaattg aatttgtgga tgataaattt aatattcaaa tggtttcaaa tgaaattggt
    37741 atcccagaga ctttaagaca aaagcaagga gctttgatta gtctaagtgg tataaatgat
    37801 gagtttcatc taaggctttt agataaggat gctgaaaaag aagggtcaga atctaagttt
    37861 gtaacagaat ttttaaatgc taaaaaaata gatgatgata agtacaagac caaggtattt
    37921 aaaaatacag ctgaaaattg gataaccaat gctcttagta atgatataaa gcaagctgaa
    37981 gatgtaagaa gtatattaaa ttatacactg aaggaaaaac atgaagttga tataaatgac
    38041 tttgttgata attcaattaa agatgatgag ttaaaggata gctttaaaga gcatatggaa
    38101 gaaaaaggtc ttgacgaaag ttttagtata gataaaaaat gggttgagaa aaagcttaaa
    38161 aaaagaagta taaaaacgga taatggtttt gacataaaag ggaatctaac tgattttgaa
    38221 gacccaatga agtatactgt aaaacaaaat caagatggaa ctatagatat aataataaag
    38281 aatgttacgt tttatgaaga aaagtaattt atatacttag tatataaatt aaatataaga
    38341 gcgtgtattt tatatattgt aaataaatgt aatctagtct gtgcgaactc taatataatt
    38401 tattatgtag aagtttacac agactattta tatttgtaga caaaacgata ctatttgttt
    38461 tcttcgatat atttacatat atcaccaata catttaaagt tttcagcttc ctcgtctggt
    38521 atttctattc caaattcatc ttcaagggcc attataattt caacagcatc taatgaatca
    38581 gcttctaagt cgtccattaa agatgcttcc atagttatct catctaaatt gtctacccct
    38641 aattgttctg ctattatttc ttttattttc tcaaacattt taagcctcct aaagcagttt
    38701 taattaattt taatgttagt ttaatataat atcaagaatt tttcaatatg gaatctataa
    38761 aaaataataa aattttataa atgtagtaat aaagtattat ttgatgaata aactttattg
    38821 ataacaaata taacttagga ggaaatgcta tgaaatatgt aggactatta ctaacttcag
    38881 taggaatgtt tttacttata gcagtaaatt tttattataa ttcaataact ttagatatgc
    38941 aacgtataga ggattatgta atggagacca atttaatcct tgaagatgta gctgaaaagg
    39001 agagttatgt atctaatgaa aaagaagatt acatatcaag gttaatgcat gtaaagaaag
    39061 gaatagaaaa ttcaaaaaca tccttcttga tagaaagata taaggagtac aaaataaaat
    39121 caatagaaag tttaatctat actatatcag aggagaaaaa agattatctg gatgaagttg
    39181 atagatacaa taaacttggt gaaaaagaaa taaataaact aatcaataaa aactttttag
    39241 aagtaactta tctgtctatt actacatata tttaattaaa gagacaaaac ttagtctctt
    39301 aatgattcaa ggaggattag ttatgacaaa attagaagac aatatggaac gtttctttgg
    39361 aggatgcgaa ggattttttg ggaataaaat gttgataata atagttatag tattcttact
    39421 attatgcaca gacattttag aagacttatt atgcgatgac aatatatgga tatgggttat
    39481 attaatagta ttgttattat ttaacttcga tgatggttgt tgttgctaaa aaatattgat
    39541 tattaaatag gtaaaaccag taacttatac aagttatggt tttacctttt ttagttcaaa
    39601 ttaaaaaatt taaaaaaata gtaaaaatac attagcaaaa tggaaaccaa atgcatagta
    39661 tatgttagga gcgaaaagct caacaaaata tcaacaggag gtaacgtata atgttagata
    39721 gattctttgg agaagaagga tgttttggtg gaggaggatg gtggataata gtactattct
    39781 tcctattctt agcttttgga gatagctggg cagaatttga cataatggca tggataccat
    39841 tcctaatagt tttattaata ctttgctgct gtggtggatg cttagaataa gaacacagtt
    39901 attaaaaaaa ggagggcttt gttatgttag atagattttt tggagaagaa ggatgctttg
    39961 gtggaggagg atggtggata atagtactat tcttcctatt cttagctttt gaagattgct
    40021 ggagagacat tgacataatg tcatggatac ctttcttaat attattgcta ataacttgtt
    40081 catgtggtgg attctttgat ggtgaagtag gttgcggctg ctaatactta aatcattaga
    40141 ataaaaaaat gctggtattt tataccagca tttttttatt ttatttttta atatgattta
    40201 aattaagaat gaatattatt aaatttgttg aatatagggt ataatataaa atataatgta
    40261 tttaaatgta cttgctttta tggtaaaata aaaacttata taaatgtagt taaaatagga
    40321 accttcaaaa atttggttca gttttagata aatttagtaa aataaggagg atgaagatga
    40381 aaggcaatat aacgataaaa gatgttgcta aacaagcagg agtgtcaata tctactgtat
    40441 ctagagttat aaatgattca aaacctgtaa ctgatgaagt caaacaaaaa gttttagagg
    40501 ttataaaaga gactggatat ataccaaatc cacttgctag aagcttagta acaaagaaga
    40561 gtcaattaat aggggtaata gttccagaag tttcagattc ttttgttaat gaggtgttaa
    40621 atgggataga agaggttgct aaaatgtatg actatgatat tcttttagcg aatacatact
    40681 ctgataagga acaagaactt aagagtataa atctattgag agcaaaacaa gtggaaggta
    40741 tagttatgat ttcatggata gttgaacaag aacatatcaa ctatatacaa aattgtggaa
    40801 taccagcgac atatataagt aaaactgcta gaaattatga tatatataca gtaagtacta
    40861 gcaacgaaga agctactttt gatatgacag agcatcttat aaagaaaggt catgaaaaga
    40921 tagcttttat aatgactagt aaagatgata ctgttttaga aatggaaaga cttgctggtt
    40981 atgagaaagc actttcaaat aacaatatag aattagacaa gagtttgatt aagtatggtg
    41041 gaactgatta tgagagtgga tacaatagta tgaaagaact attagatgat ggaataatac
    41101 ctcatgcggc ttttgtaaca ggtgatgagg ctgccatagg tgctataaat gctatatgtg
    41161 atgctggata taaggttcca gaagacatat cagttgcagg atttaatgat gttaagatag
    41221 ctagaatgta tagacctaaa cttactacag tatatcaacc tctatacgat atgggagcag
    41281 tagcaataag aatggttata aaattaataa ataaggaatt aattgaaaat aagaaaatag
    41341 agttacctta tagaattgtt gatagagaaa gtgttacaga aagaaaaaaa taaaactatt
    41401 aaaatcaatc aggtagtgcc ttaggcacta cctgattttt tatgtcaata atatcaaatt
    41461 taataataga ttaactaaaa ataattatct aattgcttaa atagtttatt tttatctatt
    41521 catgaggatt agacttttta gttttcttaa ataaactttt agattttttt tgttgactac
    41581 ctggtgtatt ttttggtgca ggtgaatttg acttaccttt agtaggttta gccttcttag
    41641 ttttagctgg tttagtatct ctttggtttt ctgcatctga gattttttcc attatattat
    41701 ccagtttttt gcgttgattt tcatctaaaa atgctttgaa ttttgatact acttcatctc
    41761 tgccatctag attcttacct atttttataa gttcctccat aagttcattt tctgattttc
    41821 ctttgtaact atcagccatc ttttctattt tatccttgtc aatatttttt tgtttagcca
    41881 ttttttctaa tgactctgta tctaattttt tcataaaaaa acccctttct ataaatatat
    41941 attgaattat attcatacta tttatatata gaaataatat tgaagtggtg aattgtgagt
    42001 gatatataat ataaataaaa attcttatag ataatatata tgcactgagc tttaaaaatg
    42061 gaacattaaa atatgaaaaa catactttaa tatagggcaa ttatataata taagggggaa
    42121 ttgtcttgaa taacttacta tttttgattg gagtgattgc attgagtaat ggtaatatct
    42181 ctatatttga tgataaaaat aaatcaaaag gaaataatag agttagaaaa aacaaaaaaa
    42241 atgcaaatga taaactttca cagtctacac atggcaattt aaggtttgat gcaaatgata
    42301 taaaaagagg tttaaggctc atggatttaa gtgaagaaga tttagaaatg ggaatggaaa
    42361 taataacaag aactaaaaaa tacatgtcaa gagatgaaag aaaaatacta ataaaaatag
    42421 aaagtgtttt agatttagtt agaggaataa aaaaattaaa taatatagat atggtagata
    42481 cagaagatga aacggatttt ttcagaaaaa tggatagtga tgataaaaag aatatgatga
    42541 taaaggaaat tatagatgta ttcccagaaa aaagaaaaaa ttcagttgaa aaagctatag
    42601 gaatgaaaaa gaagatagat ttatttgcag aattattttt accagatgac tttggtgaag
    42661 gtggatttag tttgagctct ttggcaaata taaacaatct tggtagtatg aataatctca
    42721 aattgttagg aagtctttta agaggtgatg atagtaataa tgatgatgaa gacaataatg
    42781 atgagttaaa ttatgaagac gaagaattag attgtgaaga caaagaattg gatgatgatg
    42841 agttaacaga tgaaggtgaa atggaggata atgaagatga attagtagaa gataagaaca
    42901 caggctatga aaatatagaa aatgatgaag atatagtata cgatgaggaa ctatacaaca
    42961 ttaatgagca agaatccgaa tacaattata atgaaaaaaa tactaaaact agagctaaga
    43021 aaaaacgata attaactaaa tacataaaga aaaaaggaag aaaaagtaat gatagaataa
    43081 gattatctca attactatat aaaaccactt taaaaaattc aaaatttatt atataataat
    43141 aatatgaaat cctgaaacat acgataaggc ttttttaaat tcaacctaca aatgaaatac
    43201 gggagaccgt gtctggtaaa ttataacatg cctagttagt ttggacgtta aaggttactg
    43261 gcaagtcacc cacctgggag tgcctagggt gtgaatttac ttagccaccg gtgtttcggg
    43321 acaaaaaaag tgctactatt tcaaatagta gtactttttt tattaatatg catttttcta
    43381 ctaaatacgc ctaattattg ataaattcaa aaagcaagta acaattaaga ttataaaagc
    43441 atagtattaa ttaggcttca aaaagccaaa gacttaataa gaatcgctta cagggagggc
    43501 aatgaaaaat gcaagattat aaaaaaaata aaagaagaat gatgaatcag ccaatgtcta
    43561 caatgaatga agaagaagtg tatacagatg aaataaattc agaagacatg agaggtttta
    43621 aaaaatcaca ccatcataat ggatgtaata ctgataataa gtgtgagtgc catgatgatt
    43681 gcaatccatg caacccatgt aatccatgta aacctaaccc atgcaatcca tgcaaaccta
    43741 atccatgtga tgacaattgt ggatgccatg acaattgtaa atgtgattgt gaaccatgtg
    43801 aaatggattc agatgaatgt tttgaaaaca aatgtggacc agaatgctgt aatcctatat
    43861 ctccaagaaa cttctctgta tcaaatgcag tgccatttgc aatagaggct aatagaatat
    43921 ttgatactat gcaattccaa acatttacag atgcaacagg accaaatgga gagccattaa
    43981 cttttgaaac agaagtagta gaagtatttg gttcagttcc aagtgcaggt caagcaagtg
    44041 taactataga aaaaatatgc ttaagtaatg atggaatcgt tatagacaca ggaatgacaa
    44101 ctttagaaga tttcgattta gacccattag gagatatagt aggaagaaac tgtgaaacaa
    44161 cttttgaatt tgcagtttgt ggagaaagaa actctgagtg ctgtagacaa ggaaaaggca
    44221 aatcagtagc ttataaacaa agaggattaa ctgtagcagt tcgtaattta gtactagagc
    44281 taagaggtag atgtggatgt acagagttcg ttgcattagc tttcccagca gttagagcag
    44341 gaggtggatg taagagaaga gttgattatg tagaatttac ttttaacaca ctttcagcac
    44401 caatatgctt gccagctgac ggaagagctg ttactttaag acaagaatat caaactaact
    44461 taactgtaga ttgtatagga aaatctatat taaaattaga atgcaacgaa tgttgtgaac
    44521 ctttctatga attaattata ccaaatgata tagatttagt actttgctta caagaaacag
    44581 ttagcacatt aataagtgaa caaatagtag ttttagcatc accaaatcca atccaaccaa
    44641 gacttgttga tactttctct aaagtatgtg atttttcgca atgtggacct aatcatggaa
    44701 gtggaaagcc aagttgccac agatagatag gtagatatat agacagttta aattataaat
    44761 aaaaatcatc taaggaaggc taccaaagtg tataatttac attggtagcc ttcacgtttt
    44821 tataactagc gtatagattt tagtgattta aaaagcacta tagtatgtaa tagacaagta
    44881 aagattgata ctatcgtcat tgtgtatatg tatgcataaa tattaagtcc tggaattgga
    44941 agaaatacat ataaagctat tagttgaatt aacatgccag taatagtatt tatacttgaa
    45001 gctaattctt ttcttattga atgtaaaatg ccagatagag tttgatttag ggacataaat
    45061 agtggaacta aaaacatagc ttttagatat tctcctgcaa gtgtattttt aaatactaat
    45121 atacataaat cttttccaaa gaaataaaaa aatattgatg atagtatgcc tacaaataaa
    45181 gtaagaagta tggagtattt gattttttta attacactct tacgctttct tagagccatt
    45241 tcttgtgaaa tagttggtat taaatttaca ataagcgctg aaccaacagt aaaaggtaaa
    45301 aatataaaag gcattaccat cccactgaca ataccataca tacttaaaga ttgttgataa
    45361 gtcattcctg ataatgctaa tcttgatggt atcatcatag aacttataga ttgcaaaagt
    45421 atgtttgaca ttctattaca agttatggga atagacattt ttaatgtttc catagaagaa
    45481 ttataaaaat cttttatgct tataatatac ctattgtcaa atgatgaatc tcgccataag
    45541 caaataagca taaatataat attactcaac tcaccaatcg atatacctaa tagagctata
    45601 taacaattca tagatttatt atttatgtac ataacaagta aaaaaacaaa taatatttta
    45661 ccaatttgtt caatgatttg tccaatagca gggattttta cattctttat gccatagtaa
    45721 tatcctctta gtacgtttga aagagttatt ataactatag caggacaaac agctagtata
    45781 aatagattta atttagcatc ttttaaaaat ttaagtgata aaaaagaact attgaaagat
    45841 gcaactatag atataattag tgctacgaaa aatgatatat ataaagttga tataaataaa
    45901 gcattagtat tgtgtctatc gtttaaagct tttctctttg caactagaca actaagtgca
    45961 gtaggtatac ctgttgttgt aacagctaag caaatcatca aaaagttaaa aatcatatga
    46021 tagataccta aacctgtttc acctagtgct cttgataaga atattttata taaaaaacca
    46081 aatattctta caataaaatt ggatataaat aaaataactg ttgatagtac taaataaggt
    46141 actttcaaaa aaatcacctc cttatctttt aaatatattc acaaggaggt gtaaaaattt
    46201 ataattttat aaattctggt ttcaatttat taaatttaga tacatattta aatcccatat
    46261 tttttagtaa tgaatatatg tagtcaaact cacatgcaac ttgacttata tgatgtgaat
    46321 ctgaacctgt ggttatgatt tcccctccca agtctttgta catttgaagt atatacttag
    46381 atggggttag gtctggaaga ttatatctat aacaagaggt atttatctcg atacctttgc
    46441 catcataaat agcttgttta agagtttctt caattatatc agaaaatagt ctatcatcta
    46501 aaatagtgtc ataaggtgca taccttttaa tcaaatctaa atgacctaag acagagtaat
    46561 ctttataatt cttaacaata ttatataaat aaagatagta attttcataa acttcatgtt
    46621 gagttttatc tttaaaataa ttaccaaggt ataagtccat tgtatctata gcatggatag
    46681 aacatattat aaagtccaat ggatattgat gtgcttcctt tttgtatgta tccattaatt
    46741 gagtttgaac tccaaattca attccttttt ttattgatat tttatcttta tatttgcttt
    46801 gaagagtctc taaactctta aaataatctt cgtagacaat tgaaaaagaa tcatcagcat
    46861 atacatcata gtcaacatgg tctgtgaaac aaatttcctc caaaccgagt tcaatagatt
    46921 tttttaccat ttcttccatt gtagattttc cgtctgtaga gaaacttgag tgcatgtgat
    46981 agtcgtaaaa cataaatatt tccccttttt ataaaaattt tggtattata tatacatact
    47041 aaataatatc aaatatacat aaaagcatca ataaaatata aatacaatga gcggtgataa
    47101 atttggaaaa atacagaata gatttaaatg agaaaaaatc aactaaatat atacagatat
    47161 ttaatcatat aaaagaattg ataataaata aagagttagt agaacatgaa aaattgcctc
    47221 caataagaaa actatcaaat tttttacaag taaataacac tactatagtt aaggtatacg
    47281 agcttttaga aaatgaagga tatgtatata aaattatagg gagtggtact tttgtatcaa
    47341 gtttaaattc ttataaaagc ggtatagata acaggaaaaa taagattatt gtgcaaagag
    47401 aagatttaat tcattttgac aatgggaatc catctaatga tatgtttcct atcgattcat
    47461 ttaaaaatgc tgtaaatatg gcattatcta aagatggtag ttcaatattt gaatatgatg
    47521 aaggtcttgg ctctgaagaa ttaagagaaa aaatggtaga gtatctaagt gatggaaata
    47581 taaaaactac taaggaaaat attcaaataa tatcaggtgc tcaacaaggt atagatatag
    47641 tttgtaaagg acttataagt tattcagatg ttgtttttat ggaagaacct tcttacaatg
    47701 gagcaattga agtgtttaaa agtagaggtg caaaaataat atctatacct atgttagatg
    47761 atggaattga tataggtatt ttaaaattaa agttggaaaa aataaaacca agacttatat
    47821 acattatgcc taattttcaa aatccaactg gaatatctta ctcaacatat aaaaaaaaga
    47881 aattgataga attggcagaa gaacatgatt tttatataat agaagatgat tttataagtg
    47941 attttgtttt tgaatcaaag gacaatagaa caattagaag ttatgatgat aaaaatagag
    48001 tagtatatat aaaaagcttt tcaaaaatac ttatgccagg tcttaggata ggaattgtag
    48061 aaatgccaaa tgagttgtta aaaaaagttt tatgggctaa atattcatca gatatatcaa
    48121 caccaggttt aattcaaaaa tcaatgtatt actatatgaa taattttgat tggaagaatt
    48181 atttgagtca tatagagaag atatatactg ataagtataa attggcaaaa aacttgatta
    48241 atgacaaatt gagtggtaaa ttaaaagtta gaaaatcttg tggaggaata aacttttttt
    48301 tagaattacc aagaggatat acatctcaag catttacaaa ttttatgtta aacaaaggag
    48361 tgtcaatgct tccagggact tatttttttg acaatctagt ggatgataga ttctttagga
    48421 taaatatagc tcgtccaagc atggaagaac tagaaaaggg aatatctata ataagtgata
    48481 atatagatga gtttttttgt gaatataaaa acaagttaga tataaaaagc aataaattat
    48541 tttattaaat aaatagaggt tttttaggag gaaaaaatgt ttgacaagaa gaaattagat
    48601 aggattaatg aattagcaaa gaaaaataaa gagggaatcc tttctgctga tgaaatcaaa
    48661 gaaagagaaa ttttaaggaa agaatattta gaaaacttta gagcccactt tagatcaaga
    48721 ctagatagtg tcaaagtagt ttcaccagaa gaatatgagc aatacatgaa aaacaataaa
    48781 aattagaact tagtaggagg aaaatatgaa cttaaagtac gaatttaaga atgcttggga
    48841 ttttgaaaga aaagaaaata ctattgaaca aattatgcaa tattctagca attatatgga
    48901 gtttttaagt aagtcaaaga ctgaaagact ttcagtaaaa gaaattataa aattggctaa
    48961 agaaaataac tatatttcaa tagatgaagc tatggaaaaa ggaagcataa gttgtggtga
    49021 taaaatttat gttataaata aagagaaggc agtagcactt tttgtaatag gtaaaaatta
    49081 tatagaaaaa ggtatgaaga ttataggaag ccatatagat tcgccaagat tagatttaaa
    49141 accaaatcca ctgtatcaag agagtaatct aggttttttt aagactcatt attatggtgg
    49201 aataaaaaaa taccaatgga cggctattcc acttgcttta catggtatag ttatattaaa
    49261 tgatggaaca aaagtggaca tatctattgg ggaagaagat agtgacccag tattttgtgt
    49321 aactgattta ttgattcatt tggctggaga ccaaatgcaa aagaaactat cagaaggaat
    49381 tagtggagaa gctttaaata tattaattgg gaatatgcct ttagaagatg aagaaaaaga
    49441 acctataaca gcaaatatat taaagatttt aaatgagaaa tacaatatag ttgaagaaga
    49501 tttattaagt gctgaaattg aagtagttcc agctggtaag gctagagatt tagggcttga
    49561 taggtctatg gtgttgggat atgggcatga tgatagggta tgttcatatg ctgctgtaaa
    49621 agctatacta gaaactgaac aaccagaatt tacttcagtt gcattatgtg tagataaaga
    49681 agaaattggt tctaaaggga atacaggtat gcactcaaag ttttttgaaa atactgtggc
    49741 tgaactgatt gctttagaag gagattattg tgatattaaa gtaagaagag ctttagcaaa
    49801 tagtaaggta ttatcagctg atgtttctgc tggatatgac ccaaattttg gagaagcata
    49861 tgaaaagaga aattcggcat atatgggaaa tggagtagtt ttaactaagt atacaggttc
    49921 aagaggaaag agtggatgta atgatgctaa tgctgaattt atgtcagaag taaagagaat
    49981 ttttaataaa ggaaatgtag tatggcaaac tgctgaactt ggaaaagtag accaaggagg
    50041 aggcggaact atagcccata tattggcaaa tcaaggtgca gaggttatag actgtggtgt
    50101 tggagtttta aatatgcatg caccacatga gattgtctct aaagtagaca tatatgaaat
    50161 gtataaggga tataaggcat tttttaatat aaatttataa gtaaaaatat aaatgtaata
    50221 agtgaataaa ggctgttgta taaacaattt aatctgttgt acaacagtct tatttttatg
    50281 taaaaatagc aatttgtcac actagagaaa ataaaagaaa atactgtcaa attaaaaatt
    50341 attttaaaaa aaattgacaa cgatttcatc ttgttataat atgtaataaa gaacttgtta
    50401 tataatgtta taaaaatgtt acatagggag gtgagcaaaa tggatgaaaa gagacaaaaa
    50461 aaagaaatgg atttagaagt aaattccttt gttcctttat atcaacaact atatgacaac
    50521 ataaaaaaac aaatagcatc tggcatatat aaaccaggag ataaacttcc atctgaagga
    50581 gacttatgta aagaatttaa tataagtcgt ataactgtga gaaatacgac ttttttatat
    50641 aaaatagcaa aataacagtg tttgagcaaa aaaaaagaat gttttttatc gttttgccac
    50701 ctgtttgcca ccataacttt tttcggtggc aaattattgt aaaatgccct ccaaaatatc
    50761 tattgtttca ctttccattt tacttgtaac atgtgaatat gtgtccatag tggttgataa
    50821 ttgactatga cctaatcttt gttgtatata ttttacatta gctccatttt ctaataataa
    50881 tgtggcatgt gtatgtcgca agcaatgaaa attaaagtta atatttagtt tcttgttaat
    50941 agttcttata gcagcgtcaa tattgttgtg atttacaaat gagccatctt tttttctaca
    51001 aacccaatca tactcagttt ctttatacca ttttccaatt ttaatttttt gttttttttg
    51061 attcaatttt tcctctttta atatcctaga caaagtatca cctattttaa tatctcttat
    51121 tgatgttttt gtcttaggtg atgctaattc aaattctgaa acttttctct ttattaaatt
    51181 ttttctaact ttgattatat tattatctaa atcaacatta tcccaacaaa gacctaatat
    51241 ttctcctttt ctcatgcctg tatgaaaccc tataagtaga ggaatataga tatttgtatt
    51301 tttaggatat atttctagta ttttattgaa ctcatctagt gttatagtct tgttatctga
    51361 ctcatttttt acctttaaaa cattttttgg tatactggca tattgaacag gattttcctt
    51421 aatgagtttg taagggtaaa cagcagattt taaagcagca tttaatacaa cataaatcgc
    51481 ttttaaaact ccttttgtgt agtgtttttc ttctccgttt tgtgtgtatg tctcttttga
    51541 tttattattt aaaaattctt gaataatagc tggatttata gattttagct tacatttacc
    51601 aagtctaggt tctatatgat tttcaattaa atttctataa ctttcctgag tattgtattt
    51661 gcaattaaga agtacatact ctttgtacca aaagttaaga tagtctgata aactcatatt
    51721 tgtttcatca aacactatac cagcattttc atattcattt attgcatcac ggagcgattt
    51781 ttcagcttct ttcttagtgt ttccaccaac tctttctacc ttttttctct tgccatctac
    51841 tatacctgca tcaaagtagt aataccactt ctttccacgt tttcttacgc cgcctttcat
    51901 aaaatctctc ctctcaaaag ctttttttat gtaattatat aataacatat atcaatttaa
    51961 ataaaataaa taaaaaagac tataagaaac aaagttttat gtttataatt aatagtcttt
    52021 tttatttaga tacatattta atgtttttta tcacgtgatt ccagcacttt ttctgccaaa
    52081 taaacaacta ttttttcata ctcaatatca gtttctaaag aaaagtcaac aatagcaggt
    52141 atcgtcatat ctcctgcata tttattacct aaccaatttt caattaattc caattcttct
    52201 ttgcttaatt caaatttttt ctttttatta aaacttaagt tcaatttatt cacctcaaat
    52261 aatattatat attaaaaata gtatttgata gaaacattcg aattatttat gtaattttct
    52321 ttttttaata tattcatcag caaaataatt tactaaatat ttttcctcca atcctaaagc
    52381 tatttctaat tcaataagag cagggatagt taaatcttta ttctcattat tttccaacct
    52441 agaaatttga cttctgtggc aaccaactct ttttgctaac tctatttgtg ttaatttctt
    52501 cttttttcgt aactctttta acatatattt aacctacctt ttagataatt ttatatatgt
    52561 tagtttgtgt aatttcttgt aataaatgtg caatattcgc acactttttg ttggaaattt
    52621 gtgctagaat gtagttaaga aataacttta tctagataaa gcaaaaataa tagaagctat
    52681 aaaatataat aatattttac agttatttta tagttttaag ctttgaaaaa gaggtggttg
    52741 taactatttt taagaacgta tgtttcgt
//
LOCUS       DAEPID010000022        52364 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.022, whole genome shotgun sequence.
ACCESSION   DAEPID010000022 DAEPID010000000
VERSION     DAEPID010000022.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 52364)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 52364)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..52364
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.022"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            complement(263..550)
                     /locus_tag="KR257_001414"
     CDS             complement(263..550)
                     /locus_tag="KR257_001414"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003431103.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIB"
                     /protein_id="HBH0030123.1"
                     /translation="MKILAVCGFGVGSSMVLKMTIQKALKQLGIECEVENTDINSARG
                     ADCDCIFTSQELLNELKGTCNVDVYPVKKYMDLAEVTEVVQTFLSDKNDKK"
     gene            complement(563..2482)
                     /locus_tag="KR257_001415"
     CDS             complement(563..2482)
                     /locus_tag="KR257_001415"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897758.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcription antiterminator"
                     /protein_id="HBH0030124.1"
                     /translation="MKERAKKILDFIIKNNNVTSQELQEKFNVSKRTIYYDILAINEQ
                     LGKSGNIKNVKHKFIFEGNLCDARKIISTEEDKFLDSDYRKTFILNKILLGEKISIEK
                     LTNEMLLSKNTVVQTITDVKKYLQTMGLRLEYKGKYKIIGDEYVIRELFLIIVQENVL
                     EINSISEEVSSFDTKGHIKLTDYSLLNLTKFVEFLNKRIRDGKTLYSYKYLNEAKKIS
                     YFSNCKELLCEEANENEQAYICTYISSLPSLNSEVKEDVVEEYVDKLIDKFEVNTAIK
                     LESKHEFKKNILRHLHSSYNRIRFKFPIRNPMLDETKYKHESLYKIIKSIIENEEEFP
                     VFEGIREEEIGFIAAYFGGYLRGSRDNGLRRNKVLLVCPNGLMVSKSLEIQLYKYIPT
                     IEIVGIVSIKQLKEVNVYYDYIITTIDIQNVNNVIVVNPLLTSSDVQLLMNKLISVKE
                     NEKYFNLELIIQAIRKNGVINNEEALKADLLNIIHKIDEGEMYQPMLKELINAERVNI
                     IKNVRDWKEAIKIASKPLLEDNSIEELYIENMIKSVEKYGPYIVLADRFALPHASSKE
                     GVNKLAMSLLIVEDEVDLLGKPVNIFMVLAAVDNTTHIRALASLSEMMYEEENVKLII
                     NGDKSSIIELINKQN"
     gene            complement(2826..3350)
                     /locus_tag="KR257_001416"
     CDS             complement(2826..3350)
                     /locus_tag="KR257_001416"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454870.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0030125.1"
                     /translation="MKIDLEMIELFEQLEEIFRSASTIPFSHKCTVDKDEVLAIINDI
                     RTLIPEEVTQAVWINKERNKIISQAKQDATNIVEQAKKEAERIQQEYQDNIEELKKNS
                     EDVVKAYVESSEPVVQADQRAKDIVDRAERIANEIRIGSIEYAEDVLSSVEYNLREIL
                     EEVKRDKAELRPKK"
     gene            complement(3354..3851)
                     /gene="coaD"
                     /locus_tag="KR257_001417"
     CDS             complement(3354..3851)
                     /gene="coaD"
                     /locus_tag="KR257_001417"
                     /EC_number="2.7.7.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416314.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pantetheine-phosphate adenylyltransferase"
                     /protein_id="HBH0030126.1"
                     /translation="MENKPRKAIFAGSFDPITNGHLDIICRASKLFDELQIGVLNNPN
                     KKGLFSFDERVKLIEKSTSHLNNIKVVTFDGLLINYCQENGIGALVRGVRSGADVDYE
                     LQMAHMNRELNPDIETIILPSCTKYSFISSSLIKEVLLFDADIKNLVPKIVLEELKKK
                     TSGGN"
     gene            complement(3853..4407)
                     /gene="rsmD"
                     /locus_tag="KR257_001418"
     CDS             complement(3853..4407)
                     /gene="rsmD"
                     /locus_tag="KR257_001418"
                     /EC_number="2.1.1.171"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003431108.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="16S rRNA (guanine(966)-N(2))-methyltransferase
                     RsmD"
                     /protein_id="HBH0030127.1"
                     /translation="MRVISGKARGLKLNTPKNEDVRPTTDRVKESLFNMINSYIMESE
                     VLDLFAGTGSLGIECLSRGAKSCTFVDISKESIDIVKSNIKKARVESESIILNLDFKT
                     AIDKLKLQNSKFDIIFMDPPYYKNMFIEAIEKIDNSNLLNEDGIIVVEHDTNDLFPDK
                     ICKLEKTRDKKYGNTTLTFYKMEA"
     gene            complement(4466..6523)
                     /gene="recG"
                     /locus_tag="KR257_001419"
     CDS             complement(4466..6523)
                     /gene="recG"
                     /locus_tag="KR257_001419"
                     /EC_number="3.6.4.12"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416309.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-dependent DNA helicase RecG"
                     /protein_id="HBH0030128.1"
                     /translation="MDLYKDVQYVKGIGPKKADKLNKLGIFTLKDLLYYFPRQFEDRN
                     NLKKIAQLEDGEKVTIKAVISSINTFSPKEGMTLTKIDVKDETGSAKLVFFNKSYIKN
                     TFRPGDSILVFGKVKKKFNNLELTSCELEYLTNSPKNTCRFMPVYQLTYGVTNKEIMS
                     IIRTVLEDKELIIQEYMPQRIIEKYRLCSIDFAVRNIHSPSSKESLKIALYRIVFEEL
                     LILQLGLFVFKSGRNKEDGIKFETSKDLKKIISALPFKLTKAQNRALDEIIQDMNLEK
                     IMNRLVQGDVGSGKTVVALLALANCVLNGYQGALMAPTEILAGQHYISLTESLKDFGI
                     NVGLLIGSLTKKQKDTVLEQIKNNEIDILIGTHALIEDKVEFNNIGLVITDEQHRFGV
                     MQRSKLSLKGANPDILVMTATPIPRTLALILYGDLDISIIDELPPGRQPIETIAIEKS
                     KRDRAYNNLVRREVESGRQVYIVCPLVEESEAIEAKSAVELVEELRAEYFHDLRLGLL
                     HGKMKSSEKDEVMRLFKDKEIDILVSTTVIEVGVNVPNATLMIIENAERFGLAQLHQL
                     RGRVGRGSHKSYCVLIYDSKTDVCRQRMAIMEETNDGFKISEKDLEIRGPGEFFGTRQ
                     HGLPELKVANLFKHIKILKLAQQEARYILGEDNNLQLKENMALKKEIIDKFKDTLKEI
                     SLN"
     gene            complement(6604..8247)
                     /locus_tag="KR257_001420"
     CDS             complement(6604..8247)
                     /locus_tag="KR257_001420"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897767.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DAK2 domain-containing protein"
                     /protein_id="HBH0030129.1"
                     /translation="MIQYIDGKRLREMFISGANNLQNNKELVDKLNVFPVPDGDTGTN
                     MSLTISYALKELAKVENDNISDIGKALSKGSLMGARGNSGVILSQIIRGIAKSIEGKS
                     KLSTEDLAKAFKNGSDTAYKAVIKPIEGTILTVVRESGEFAIKTAKKEKDVVKFLSML
                     VKESNSSLERTPDLLKNLKEAGVVDSGGKGLVLIYEGMLASIKGDNIEIKNVDLDTNI
                     STSMDFAKSTTSTDDIKYCYCTEFILESSKVEDTKIRDIMMAYGDSLAVVGDDGVIKV
                     HVHTNDPGNVLQEALKYGQLLTIKIENMKLQHENTLLDVEEKKENDSEPLEEEKEFGF
                     IATSMGEGLANIFKDFGVDHIIEGGQTMNPSTEDFMNAIKHINAKNIFIFPNNSNIIM
                     AANQAKELSDKNIIVIPTKNTPQGFAALVTFNGELSEDENKEAMMNALNSVKSGQVTF
                     AVRDTVMNEIDVKEGNIIGIAEGNLLSAGDYVDEVTSNLIEKLVDEDTAIITLFFGED
                     VTESQANELRTSLEEKFEDVDVELYYGGQPLYYYLISVE"
     gene            complement(8266..8616)
                     /locus_tag="KR257_001421"
     CDS             complement(8266..8616)
                     /locus_tag="KR257_001421"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003431114.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Asp23/Gls24 family envelope stress response
                     protein"
                     /protein_id="HBH0030130.1"
                     /translation="MSAKVTNQYGNIEIDNQVIAQVVYRAAMESYGLVGLAYKSKGIV
                     ELLKGENATKGVRVEEVEEDAIAIELYVIIQYGTNISTVANNIIDRVKYVVEKMTGVR
                     VTRIDINVQGIRVK"
     gene            8977..9165
                     /locus_tag="KR257_001422"
     CDS             8977..9165
                     /locus_tag="KR257_001422"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416297.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L28"
                     /protein_id="HBH0030131.1"
                     /translation="MAKVCSVCGKGKVSGNQVSHSNKHNKRTWSANLRSVRAIIDGAP
                     KRVKVCTRCLRSGKIERA"
     gene            complement(9325..9477)
                     /locus_tag="KR257_001423"
     CDS             complement(9325..9477)
                     /locus_tag="KR257_001423"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893656.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="2-oxoglutarate translocator"
                     /protein_id="HBH0030132.1"
                     /translation="MRNNKSKVLLGILCLATGMAVILSMLLPGWIWSALTALILIGCG
                     ALLFFC"
     gene            complement(9575..10051)
                     /locus_tag="KR257_001424"
     CDS             complement(9575..10051)
                     /locus_tag="KR257_001424"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454873.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Rpn family recombination-promoting
                     nuclease/putative transposase"
                     /protein_id="HBH0030133.1"
                     /translation="MNLKRSNEKREEYRRMYSDKESFLSLIQNFTSVSIAKELTLKNI
                     ELETSFICEYKGKEVDIIYKVFSKSGKVSHYIVLEFQTEMDTEIVPRLKSYREQIWKS
                     FIMKKSLEEIEDKNFKLPKVIPVVLYSGPERLSRKKGILDIVESISEFSNNSSMKN"
     gene            10270..11031
                     /locus_tag="KR257_001425"
     CDS             10270..11031
                     /locus_tag="KR257_001425"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454874.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MerR family transcriptional regulator"
                     /protein_id="HBH0030134.1"
                     /translation="MEYTVQKLSKLAGISTRTLRYYDEIGLLKPLKINSSGYRIYGQN
                     EVNKLQQILFYRELGINLENIKNIINSPNFDSLSALKEHHNKLLAKRKQIDLLIENVT
                     KTIALKEGKYTMTDIEKFEGFKEKMIDENEKNYGTEIREKYGKDIIDTSNKKLKNMSK
                     QDYENWQNLNIEIISKLKKAFKTGDASSELAQEVAKLHHKWLSYTWNTYSKEAHSSLA
                     QMYVYDERFTSYYDREQPGLAKFLRDAIVIYTRDK"
     gene            complement(11291..13219)
                     /locus_tag="KR257_001426"
     CDS             complement(11291..13219)
                     /locus_tag="KR257_001426"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454876.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcription antiterminator"
                     /protein_id="HBH0030135.1"
                     /translation="MHKRLLTLFKLLNESDDKITCKTLSNHLKVSERTIRNDITSING
                     TLEKNGAIIKIKKGEGYYIDILNLALYQQYLALISDDIMDSSEIPDSPIERNQYILKY
                     ILYNNTYIKLEDLANSLYVSKFTILNDIKRIKPILSKYNLILVSKPYYGVKVEGKEID
                     IRRCISNNMINRNFENYIIGITDREIELFNNVDLIELQRVVLSEINKFNINFLDFNLK
                     NFIIHLAITVSRILDGYCLDNVLDVVLTDFQSNTTVENIFNYIESKYTIIISKADRVY
                     LYNHFITKSSLLDNVSNRVDTKIIEYVEEILEVINNQYTFDLRNDSVLFDDLVLHFKS
                     ILNSKSYNLNKVNPLINTIKSNYPLAFEITLNAIEKVFKNSIYSLTEDEIGYVSLHIG
                     AGIERFFQSNIKCKNVVLVCGSGYGSSRLLEVQLNKVFHDKINILQCLSFNQFLASEL
                     SDVDIIISTIPLNHDSIPIVLVDLKLLKKDIENISKSITNNSHIYSNLLDNFFDKNLF
                     IVNPKIKDKDELIKLMCNKLTQSEIVFPSFAESVFYRESLSSTNIDDFLAIPHPMELS
                     SIRTKICISILDEPIYWSEDSTVKLIMMLAINKDDYIKINSIYDILLKIIHDNDIRDS
                     ISNCNDFDNFLSIIKSIV"
     gene            13453..13905
                     /locus_tag="KR257_001427"
     CDS             13453..13905
                     /locus_tag="KR257_001427"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729391.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIA"
                     /protein_id="HBH0030136.1"
                     /translation="MVLQEKYIFIDKDLKSKEEVLNFIADSAYILGITTNKEALLKDL
                     LKRENEFPTGIKDGFAIPHTKSVNVKEASILYIKTTNELEWKTLDDSKVRYVFSLLAP
                     HKNEGNIHLKTLSKLATCLMEDDFTNEVKNASDASHLVKYITNKMKEE"
     gene            13908..14216
                     /locus_tag="KR257_001428"
     CDS             13908..14216
                     /locus_tag="KR257_001428"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454881.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS fructose transporter subunit IIB"
                     /protein_id="HBH0030137.1"
                     /translation="MKIVAITSCIAGLAHTPMAAKALEQAASKMGHEIKVEQQGAMGR
                     VNTITKEEAQDADFILIASDQTISGMERFDGKKVIKVKIGIALKKPEAVLTKCIEAIS
                     "
     gene            14330..15436
                     /locus_tag="KR257_001429"
     CDS             14330..15436
                     /locus_tag="KR257_001429"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416284.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS fructose transporter subunit IIC"
                     /protein_id="HBH0030138.1"
                     /translation="MSKKNKSLLSELKGHLMTGISYMLPLVIGSSLVVAIPKLTALAM
                     GITSLDAYKNVSGFYHILYLMEQVGWTGIGLLNTVLAGFIAFSIGEKPAMGAGFIGGL
                     IASNTNAGFLGAVIAGFFAGYVCKFLKKKIKISGSASGMMPLIIMPLITVGLTGFLMS
                     VVLAGPLGNINTSLNAWVAEMCQNGTNSVVLALILGAMIGFDLGGPVNKAAWMAGNAL
                     LLEGIYLPAILVNCAIVIPPLGYGLATFIRKSKFSNALAETGKGNIVMGIIGITEGAI
                     PFTLTNPLKLVPVNMIGCALGVGLSALLGVHAIMPPVGGLYGFISIGSGWAYLVGAIF
                     GALVIAILSTTLVDFNEDETTENTEFDEIELDIM"
     gene            15511..18189
                     /gene="mngB"
                     /locus_tag="KR257_001430"
     CDS             15511..18189
                     /gene="mngB"
                     /locus_tag="KR257_001430"
                     /EC_number="3.2.1.170"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454884.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="mannosylglycerate hydrolase"
                     /protein_id="HBH0030139.1"
                     /translation="MKKTKVHVVPHSHWDREWYFTTSRSKIYLMKDFQDILDILEEKE
                     DFKYFTMDAQASLLDDYLKWRPQDEYRIRDLVQRRRLVIGPWYTQTDQLVISGESIIR
                     NLYYGIDRCNEFGEPMRVGYVPDSFGQSAQMPQIYRGFGIDSSLFWRGVSDDMVDTTE
                     FIWKGSDGSKVLAVQIPFGYYYGGNIPEDDSDLKEYLKDIIGKLKVKASTNNVYFPNG
                     FDQAPIRKNLPDILKKANEIDNENEYEISDIENYIDSVRNERNEFTELKGEFLNAKHM
                     RIHKSIFSSRSDLKIMNNKLENYITNVLEPLLTLSYSLGNEYPHLVIKDIWKLMFENA
                     AHDSIGSCNSDTTNEDVYTRYKQARDLSINLLDLHMRLISTQIKNNNEEITLTVFNGF
                     PEVRNEVVEFDTYIPGQDFVIKNKNGKILNYIIKEKEDITNYILTQTIRLNPSKKIYI
                     PKTVYRAKIALSVKDIPPMGYTQLVFELDTKNKCEIETSNCKEIENKYYKITANKNGS
                     LEILDKESNKTYKNQAVIEDNGDDGDSYNYSPPRKDIYVSSLDSVSSVEVLKSNIQEE
                     MILKYSLTIPTSLEERAIGKVSVKMPVTMKITLEPKEQIIKFNVNIKNNQALSHRVRV
                     LFNTEIASKFSIADQQFGIIQRPTVLEKDLALWKRDNYSWQEKPITIEPMQSFVTLED
                     GQRGIALITGCVREYQIVGDNLDTIALTLFRSFGYMGRENLLYRPGRASGEKIIATPD
                     AQLLKELNFDFGLYIYNNKFDEANVANTAKRFLTPIQIYEYADFLNGRLIFAFNDEKQ
                     IYENEFSLMNVNNSNFTVSAIKKEEKGDGIVVRIFNGMKNEDAKGSLNINKNVNDAYS
                     AMLDEIYDNTSKLKVNTKTVEVNSLSHCKVQTIVIK"
     gene            complement(18506..20839)
                     /locus_tag="KR257_001431"
     CDS             complement(18506..20839)
                     /locus_tag="KR257_001431"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897776.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sensor histidine kinase"
                     /protein_id="HBH0030140.1"
                     /translation="MDTKLKKFKDKYIVTIIVFILMLSASLGMISQYSTIQASAKGGA
                     ENPFEQESFVDSIYKGSYVLYHNMKEEQEGKMIQPSKLFINEETMNYIKNVSKEKDTY
                     DGSETYYTDDSINADFNENFENWEHFIKASGKNLKYYLVDKESNFEFFNDNKELGVLD
                     TTKNDASKENSNENQSKNTEMNDEERQKQITDIKENYRFYVVMNFDKDGKVNIVDSYG
                     VNQKIINQMLLSKAREDLMDTSLGGNSISYKLSPIKNITLVYAVPKVISKGDSVEYGY
                     GNTYFDDGIISYISNVENNSYYKISGMILKIILAIVVIVALAFPYRKSKELLGFDTLS
                     RIPLEILFIALAIIQGLVDLYPTVIISNTLSGNYVEYLINNDISAKMASILVSLMNLT
                     YWFVIFSIIFVFIILLKHILNVGIREYFTKHTVTGMFFVWLKKAGKAVINQIRTINLK
                     EKPNKTIVTILGINLLIIVIMCSMWFFGIILALIYSVVLFKILSDYSKKTIYEYNQLL
                     DVTKKISDGNLDVNMEKDLGFFNPIKDELGNIQTGFKKAVDEEVKSQKMKTELISNVS
                     HDLKTPLTSIITYIDLLKDESITDENRKLYIDTLDRKSQRLQHLIEDLFEVSKANSGD
                     VYLNIVNVDIVSLMKQTLLELDDKLADSSLIVKNNFSNEKIILPLDSQRTFRVFENLI
                     INISKYAMPNSRVYIDILETDNKVNIMLKNMSASEIDFSVDDIMERFVRGDKSRNTEG
                     SGLGLAIAKSFIELQGGKMNISVDGDLFKVTITFNKN"
     gene            complement(20814..21530)
                     /locus_tag="KR257_001432"
     CDS             complement(20814..21530)
                     /locus_tag="KR257_001432"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861605.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HBH0030141.1"
                     /translation="MNSYNILVVEDEKEIADAIEIYLLNQGYNVFKGYNGLEGLKVIE
                     NQEIHLAIVDIMMPKMDGITLTMKLRENYNFPVIMLSAKSEEVDKIMGLNIGADDYVT
                     KPFKPLELLARVNSQLRRYTKYLNMVGNKEQKVESDDSVFAIGGLELNENTKEVSIDG
                     KYIKTTPIEFKILSLLMRNAGRVFSADEIYERVWNENAVNTDTVMVHVRNIREKIEID
                     PKNPKYLKVVWGVGYKIEKI"
     gene            complement(21945..22601)
                     /locus_tag="KR257_001433"
     CDS             complement(21945..22601)
                     /locus_tag="KR257_001433"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897777.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nitroreductase family protein"
                     /protein_id="HBH0030142.1"
                     /translation="MELQDTIFKRQSVRKFKNQDVSDEDILKMIKAAGAAPSGKNIQN
                     WHFVVIKRRDLMEKIADVITKKQQEILVEMDKVSVDKANRFRKFVKNFTLFYLKAPVL
                     VLVFTKVYNPSGYYELELIDAPKETIDKLFIRNPGMQSLGAAIENFTLSAIELGYGSC
                     WLTSQNYAADEIEAVLEAETGFEKGEYFLGAMLALGVPEDNLKSPSKKPVEEICTFIK
                     "
     gene            complement(22656..23285)
                     /locus_tag="KR257_001434"
     CDS             complement(22656..23285)
                     /locus_tag="KR257_001434"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416276.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HAD family hydrolase"
                     /protein_id="HBH0030143.1"
                     /translation="MVDSIIFDLDGTLWDSTEEVCKVWQDVLSEHKEIELSVTKDLFR
                     SLMGLSFEEIANRLFPNLSEEERMNLLNECSLKECDYLSENGAKLFDDIEDTLKLLSK
                     KYKLFIVSNCQAGYIESFLKAHKLEQYFIDFECPGNTGLHKGENNKLIIERNKLINPI
                     YVGDTQGDANSAKFVGIPFIYAKYGFGNVDVYDYFIDSFKDLLEHDILK"
     gene            complement(23416..24057)
                     /locus_tag="KR257_001435"
     CDS             complement(23416..24057)
                     /locus_tag="KR257_001435"
                     /EC_number="2.7.6.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416274.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="thiamine diphosphokinase"
                     /protein_id="HBH0030144.1"
                     /translation="MKICIVLNGEIEDYEVTRDIIIKECYDCIICADGGANHTYKMEI
                     MPDYILGDLDSVEEEKINFYKNKGVKFEKFPSKKDETDTELCLFLAKTLKANHIDFFG
                     ALGGRIDHTLANIKLLYYLKEDGIYSRILSDKEEMYIVENEEISLYGNPGDTISVIAI
                     NGDAKGVTLTGLEYPLDNYYMKYSVPIGISNVMLSNSCKIKVEQGCVLVVRNL"
     gene            complement(24066..24737)
                     /locus_tag="KR257_001436"
     CDS             complement(24066..24737)
                     /locus_tag="KR257_001436"
                     /EC_number="5.1.3.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003431138.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribulose-phosphate 3-epimerase"
                     /protein_id="HBH0030145.1"
                     /translation="MIKLAPSILSADFAKLLEDVRKVESAGCEYLHIDVMDGHFVPNI
                     TLGPLVVKSLKKENINMVFDAHLMIENPDQYIEEFVKAGCDIITVHQEACVHLHRTIQ
                     NIKSHGIKAGVVLNPATPVDTIKHVLSDLDMVLLMSVNPGFGGQSFIPCVLDKIKELK
                     AIIDSQGLNIDIEVDGGISPKNVAEVVQAGANVIVAGSAIFGSDDIQETVNLFRKNAS
                     LEELV"
     gene            complement(24742..25626)
                     /gene="rsgA"
                     /locus_tag="KR257_001437"
     CDS             complement(24742..25626)
                     /gene="rsgA"
                     /locus_tag="KR257_001437"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893669.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribosome small subunit-dependent GTPase A"
                     /protein_id="HBH0030146.1"
                     /translation="MLEGKIIKGISGFYYVDTYNGIYECKARGIFRKQKITPLVGDRV
                     KISIVDEDEKKGILEEIDSRDTELIRPPIANVDKALIVFAIKNPKPNLSLLDRFIVLA
                     EKENLETVIILTKADLDDNDTLETVKNIYELSGYKVIPVSNITKLNIDKVKEELKENV
                     VVFAGPSGVGKSSLLNEIDENFKLQTGVVSDKIKRGKHTTRHAELLKLEFGGMVADTP
                     GFSSLALEDIEEVELKDYFIEFDKFNDCKFGSKCIHENEPNCAIKEAVTNGEISKERY
                     DSYIQLLHEIRQNNSRRY"
     gene            complement(25724..26461)
                     /locus_tag="KR257_001438"
     CDS             complement(25724..26461)
                     /locus_tag="KR257_001438"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897780.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SDR family oxidoreductase"
                     /protein_id="HBH0030147.1"
                     /translation="MKKKTVLITGGARGIGKAMSKAFAKEGYNVLVNFNKSENEAKEL
                     YTILNEKNFSVKLFKANISNREDVEDMVDYCIKEFGGLDVLVNNAGVSQDKLFTDITD
                     EDWDNMMNINLKGSFYCSQVALKYMISEKKGNIINISSIWGISGASCEVHYSITKAGI
                     IGMTKALAKEVGPSNIRVNSIAPGVINTDMLSGYNEEDIDALVEETPLMRLGTPEDIA
                     NCAIFLASDKSNFITGQVISPNGGFVI"
     gene            complement(26569..28584)
                     /gene="pknB"
                     /locus_tag="KR257_001439"
     CDS             complement(26569..28584)
                     /gene="pknB"
                     /locus_tag="KR257_001439"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454897.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Stk1 family PASTA domain-containing Ser/Thr
                     kinase"
                     /protein_id="HBH0030148.1"
                     /translation="MGDTILGNRYEIIRKIGDGGMAFVYEAKDRLLNRTVALKVLRPE
                     FVDDDEFLTKFKREAEAVASLSHPNIVNVYDVGEDGKVHYIVMEFVDGKNLKEIIQDE
                     GILDEYTALDITKQIAMALSAAHKKGIIHRDIKPHNILISNEGRVVKVADFGIAKAVS
                     NSTMTNIGSIIGSVHYFSPEQAKGKFVTNNADLYSLGIVLYEMLIGKVPFRGDSPISI
                     ALQHINDDIDFTSEEKVRIPQSVRTTIKKLTEKSSADRYQTAEELIEDIEYIEKNIDL
                     DFIKEYDDFATKKIDEKEINKVVNPTLAKPAPEKVVKPVEVADLDDDEDYYDDFYEED
                     DDEDEEEEEIMRAKKNQRPKSTPSKRTKKKKKKQESPKSRRRLKVIAAVLILILCAQV
                     FLAYKFLFAGGFGNKSLTVPNLVNMTLEEAQSAVEKEGLYLSVKSEEYNSEVDENCII
                     SQTPEGGSTNVKKGDTINVVVSKGSSQASVPNVVGLTLSNAKQLIEENNLKVGTVKYE
                     YSSIYKEGTVLSQSPGAGSSRAQEGDEVNLYVSKGSEKSNTQTPTVPDKKPTTPENNT
                     PTEPGSNSGNSGGNSGGSNSGNSGGNSGNNGSNSGGSNSGNSGGNSGGSNSGDNGGSS
                     GGSNSGDNGGSSGGSNSGDNGDSSGGSNSGDNGGTSSGTGANIGKTE"
     gene            complement(28601..29353)
                     /locus_tag="KR257_001440"
     CDS             complement(28601..29353)
                     /locus_tag="KR257_001440"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416261.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Stp1/IreP family PP2C-type Ser/Thr phosphatase"
                     /protein_id="HBH0030149.1"
                     /translation="MVYSCASHIGKIRKNNEDYCEGEVIDTEHGPIGIFAIADGMGGH
                     KKGEVASKLAVENIIDFLKENLLQHDNVKIDYIDDILKQAYNNVNSIVHKKSMEDIEF
                     EGMGTTLVTAIVYNNVLYVANVGDSRCYLLTDEKFDKITIDHSVVEELMMAHVITEEE
                     ARRHPQRNRITRAIGTDDMVVVDIFKKEIKKSDIILLATDGLTGFIDDEDIRDLILDY
                     EYERTSNISEELISMANDVSGKDNVSVIVIKV"
     gene            complement(29373..30404)
                     /gene="rlmN"
                     /locus_tag="KR257_001441"
     CDS             complement(29373..30404)
                     /gene="rlmN"
                     /locus_tag="KR257_001441"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416258.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="23S rRNA (adenine(2503)-C(2))-methyltransferase
                     RlmN"
                     /protein_id="HBH0030150.1"
                     /translation="MEKKKIVLKNFTEDELKEFMKTIDEKPFRGSQIFSWIYKGAKTF
                     DDMNNIPKSLRNKLEEVSCIGHIDIELKLESKVDNTKKYLFLLDDGNIIETVMMDYDS
                     RVTVCVSNQVGCRMGCNFCASTMDGLIRNLEPWEILDQVIKIQEDTGKRVSNLVLMGS
                     GEPLDNFENTKQFLKIINEKNGLNIGYRHITLSTCGIVPKMYELADLEIAINLALSLH
                     SPYDEERRKIMPVANAYSIEEILNACRYYIKKTNRRVTFEYSLIKGVNDSEKEAKALA
                     KLLKGMLCHVNLIPINKVEEREYEKPDKAFIYKFRDSLEKNNIPATVRMSMGSDISGA
                     CGQLRRKYK"
     gene            complement(30412..31737)
                     /gene="rsmB"
                     /locus_tag="KR257_001442"
     CDS             complement(30412..31737)
                     /gene="rsmB"
                     /locus_tag="KR257_001442"
                     /EC_number="2.1.1.176"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416255.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="16S rRNA (cytosine(967)-C(5))-methyltransferase
                     RsmB"
                     /protein_id="HBH0030151.1"
                     /translation="MDAREVGFKVLCDIEKNDNYSNIAINKHFKNLEISDMDRGLATE
                     LIYGVIENKYYLDYIINKLSKIKVKKMSTYVKIFLRMGTYQILFLDSISDYAAVNETV
                     KLSKKYDKKSSGFINAILRNEIRAKETIMDITEEDSVKYLSIKYSYNSWIIKNWIDKF
                     GQEFAEDLLEANNEKPSIYIRTNTLKISREELIEKLSEMGIVCLKVPMVEEAIKVEKM
                     KNIEKNELFKAGLFTIQDISSMIVGKVINPKEGSFVLDVCSAPGGKSTHLATLMNNTG
                     QVVARDIFEHKLKLINSTVNRLGLKNVFVERFDASEIDENSISKFDYVLADVPCSGFG
                     IIRRKPEIKYKKEEELKDITSIQKKILENASKYVKVGGTLVYSTCTIQDVENINIVTS
                     FVEENHNFEFVPIDTVNVDLDNQDKGYLKIYPNIHGIDGFFIAKLKRIR"
     gene            complement(31799..32500)
                     /locus_tag="KR257_001443"
     CDS             complement(31799..32500)
                     /locus_tag="KR257_001443"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416253.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="zinc metallopeptidase"
                     /protein_id="HBH0030152.1"
                     /translation="MYPVYGGFWGFDPTMVVLIPAILLTIYAQFKVSSTTNKYLRVNT
                     RRGYTGEQTARRVLDSNGLYDVKIEMVRGHLSDHYDPRRKAVRLSEDVYYGTSITSVA
                     VAAHECGHAIQHAKGYAPLQIRSSLVPVVNFASSISWFLIFLGFIMAGPFLKIGILLF
                     SASVLFQIITLPVEFNASSRAIVQLGNLGIIDESESRQSRRVLSAAALTYVAAALVSI
                     LQLLRLLLIAQRRND"
     gene            complement(32569..33321)
                     /locus_tag="KR257_001444"
     CDS             complement(32569..33321)
                     /locus_tag="KR257_001444"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890793.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF116 domain-containing protein"
                     /protein_id="HBH0030153.1"
                     /translation="MTDIKKYLTSVGILILILGILIGVVNFFIISLTQIFSLMINIII
                     ISLILIILCSTVVTYRVIKGKYVNSNIMKINFNIVSGLFPIISFIASSFGMSKSDIRR
                     IYIKLNNEYIYSNKYNFNPEDIIILIPHCIQENSCKLKVTNDIDNCKECGRCNIGELI
                     KLKEKTNVKIFVATGGTLARKIIMDTKPKAVVAVACERDLTSGIQDIKKIPVLGVFNK
                     RPNGPCVNTNVDMMDIEKAIGFLTGKNILVCN"
     gene            complement(33331..34260)
                     /locus_tag="KR257_001445"
     CDS             complement(33331..34260)
                     /locus_tag="KR257_001445"
                     /EC_number="2.1.2.9"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861609.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="methionyl-tRNA formyltransferase"
                     /protein_id="HBH0030154.1"
                     /translation="MKIVFMGTPDIAVPCLQKIIDEKYEILGVVTQPDKPKGRGKKLG
                     MSPVKELAIENNIPVYQPVKARDKEFIDKIKSLNPDVIVVVAFGQILPKEILEIPKLG
                     CINVHVSLLPKYRGAAPINWVIINGEEKTGVTTMYMDEGLDTGDMILKTEVNLDENIT
                     AGELHDKMMNIGAETLKETLRLIEEGNAPREVQNHEEFSYAPIMNKSLGNIDFSKSAR
                     EIHNLVRGVNPWPSAYTTYNDVIMKVWKTKVLDEKSTKDVGTIIDVSKDGIKVSTIDN
                     VLLIEEIQMPNKKRMLVGEYIKGNTIETGLVLG"
     gene            complement(34275..34715)
                     /gene="def"
                     /locus_tag="KR257_001446"
     CDS             complement(34275..34715)
                     /gene="def"
                     /locus_tag="KR257_001446"
                     /EC_number="3.5.1.88"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003431159.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptide deformylase"
                     /protein_id="HBH0030155.1"
                     /translation="MALRQIVQIGEPVLRKKSKKVEKIDEKIIQLLDDMAETMYDADG
                     VGLAAPQVGILKRVVVIDIGEELIELINPEIIETSGEQIDEEGCLSVVGEAGNVRRPN
                     YVKVRALNRNGETIELEGEELLARAFCHEIDHLDGILFVDKIEK"
     gene            complement(34733..37258)
                     /gene="priA"
                     /locus_tag="KR257_001447"
     CDS             complement(34733..37258)
                     /gene="priA"
                     /locus_tag="KR257_001447"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012816305.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="primosomal protein N'"
                     /protein_id="HBH0030156.1"
                     /translation="MNNILNLSRGFIMKKYAKVIVRSNTIYTDNLFTYQIPVFLSDVI
                     KIGHRILVPFGKGNKPTEAFVFQFTDSLDEKIKIKEIIDILDENPIFRKEDLELVYWM
                     KNRYLCTYIECINLIYPKGYKLNNYKVVLLGESLSGLNDIELKEKISTLSDKNREIVE
                     KVIDSKGKIKVDKLKYIPNLNSSLYTMNKNGIIKLCWEYKNHKNEKKVCYISLSLESD
                     KIDDYIEQNKINVGSKQKEILSFLKNNENVEINDLLDLLNASKQSINSLSKKKLITLE
                     FKDYYREPKSIYKSVLKSIKLNNEQQEAVDEIKSNMFVDDKKPYLIHGVTGSGKTEVY
                     MEIIEFALNQGLDSIFLVPEIALTPQTIDRLKSRFGDLVGVFHSKLSEGEKHDVYKAV
                     KAGKVRVLIGARSALFAPFNSLGLIIIDECHESSYKSEKNPKFNAIEVARFMALKNNI
                     TLILGSATPSIEEYYRAKSGEYKLINIKSRANDKPLPNIEVVDMKDELDKGNRSIFSL
                     KLQKEIRYAIEENNQVILFLNRRGYANFVSCRKCGYVFQCENCDISLTYHKKSNTGRC
                     HYCGYEKEIPKECPECKSTYVKPFGVGTQKIEEELKYIFPDIKTLRMDKDTTSKKGAL
                     DEILNKFKDKEADVLIGTQMLSKGLDFENVTLVGILSADMILNFPDFKSFETTFQLIT
                     QVSGRAGRADKEGKVVLQTYDTEHYAIKHAIEYDYEGFYEDEIKIRKAFGYSPFNNML
                     SVVVSGEDERLVIKNIKNMHASLIYLLEKRGINDLGFILGPNPCSISKINQNYRWQIL
                     FKDENIEINLLKGIIKYICITKRDLIFDKNINVSIDINPNSVL"
     gene            complement(37497..38696)
                     /gene="coaBC"
                     /locus_tag="KR257_001448"
     CDS             complement(37497..38696)
                     /gene="coaBC"
                     /locus_tag="KR257_001448"
                     /EC_number="4.1.1.36"
                     /EC_number="6.3.2.5"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890797.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional phosphopantothenoylcysteine
                     decarboxylase/phosphopantothenate--cysteine ligase CoaBC"
                     /protein_id="HBH0030157.1"
                     /translation="MLKDKTVVIGISGGIAAYKACDVVSKLKKLNANIHVIMTKSATE
                     FVKPLTFQSLSQNYVVEDMFEEPKTWEVEHISLAKKADLFLIVPASANVIGKIANGIA
                     DDMLTTTVMATKAQVLIAPAMNTNMYENPIVQKNIQTLKSFGYKFIEPESGRLACGDI
                     GTGKLANPDIIVEEVLTNLTKEQDLKGQSMIVTAGPTVESIDPVRYLTNRSSGKMGYS
                     IAREAIARGADVTLISGPTNLSIPQNLKKFVQIESAQDLYEAVVSNLSENKIVIQSAA
                     VADYKPKTYSDKKIKKKNDDLSIELSRNYDIAYEIGKIKEDKILIGFAAETNDLIEHA
                     KGKIKKKNLDFIVANDLTKEGAGFRADTNIVKIIDVEGNITEYPKMKKEEVANVILDK
                     VKALLEK"
     gene            complement(38701..38967)
                     /locus_tag="KR257_001449"
     CDS             complement(38701..38967)
                     /locus_tag="KR257_001449"
                     /EC_number="2.7.7.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416246.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA-directed RNA polymerase subunit omega"
                     /protein_id="HBH0030158.1"
                     /translation="MLKPSINEVLEKIDNRYYLVGTVSKRARKLIDGEEPYVSNKTKE
                     KPVCVATKEVASGKITYRLLTEEEIEIEEARHHAEQHQQISEEE"
     gene            complement(38970..39587)
                     /gene="gmk"
                     /locus_tag="KR257_001450"
     CDS             complement(38970..39587)
                     /gene="gmk"
                     /locus_tag="KR257_001450"
                     /EC_number="2.7.4.8"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003431170.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="guanylate kinase"
                     /protein_id="HBH0030159.1"
                     /translation="MFVKKGLLLVVSGPSGAGKGTICKELLKENDTIKLSVSATTRKP
                     RTGEVDGVNYFFISKEKFEEMIEKGEFLEYAQIYDNFYGTPKAAIMECLEKGQDVLLE
                     IEMQGAKQIKEVCPEGVFIFVLPPSLEELKNRIVGRGTETEAEIEKRFSCAYEEIKMI
                     KDYDYFIFNEDVKTSAKEIEGIISSEKNKVSRYKNIIIEKFKEEL"
     gene            complement(39617..40498)
                     /locus_tag="KR257_001451"
     CDS             complement(39617..40498)
                     /locus_tag="KR257_001451"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903268.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YicC family protein"
                     /protein_id="HBH0030160.1"
                     /translation="MAISMTGFGRGEYKDDNYYFLVECKTINHKYSDINIRLPRKISF
                     LEDKVRNLVKNYVKRGRVDLYIKFDLLGKEDVNLNFDEGLASQYIDILKEIKNKFDII
                     DDISVMNVAKFPDIVKIEEKEEDEDLLWSMLNQAVEDALIKLREMRSEEGKKLAEDIA
                     MRCDLLKNHIEEIEKYSSSVVEDYREKLNLRISELLDDPSIIDENRLAQEVAIYADKS
                     SITEEIVRFKSHIGQLKNTIFKDDSIGRKIDFLIQEMNRETNTIGSKSSDINITNLVV
                     EVKSELEKIREQIQNIE"
     gene            complement(40502..41332)
                     /locus_tag="KR257_001452"
     CDS             complement(40502..41332)
                     /locus_tag="KR257_001452"
                     /EC_number="5.1.1.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897787.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="diaminopimelate epimerase"
                     /protein_id="HBH0030161.1"
                     /translation="MKFWKLHGIGNDFIAIDGRFDQINPSDYTALAKKVCHRRFSVGA
                     DGLLVVKDSKVADVEMVYYNSDGSRAAMCGNGLRCFCKFVYDNCIVKKESFTVDTLDG
                     IKDIKVNLTNREINSIRVNMGKGSFIAKDVPVLTNKERFVQESIKVLDRELKVTSMLM
                     GVPHTVVIVDELDVDDVCKYGKEIENNKIFPEKTNVNFVKVEDKYNIHVYTWERGCGY
                     TLGCGTGMTASAIVCNLLNMVESSVNVTSQGGTVKIDVGDFSYMTGPAVKICEGILEV
                     "
     gene            complement(41619..42653)
                     /gene="ltaE"
                     /locus_tag="KR257_001453"
     CDS             complement(41619..42653)
                     /gene="ltaE"
                     /locus_tag="KR257_001453"
                     /EC_number="4.1.2.48"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454904.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="low-specificity L-threonine aldolase"
                     /protein_id="HBH0030162.1"
                     /translation="MRFIDLRSDTVTMPTDEMREAMAKAPVGDSIFRDDPTVNKLEEL
                     AAAKVGKEDAIFLPSGTFGNQLALFTHCLRGQEIIIGKGYHIVTHEVGAPAVIAGVQL
                     RTIDEDESGALNPELVEKAIRRDDIHEPQTGLICVENAYSGGTVVSLDNLREIKKIAE
                     KHNLPVHLDGARLFNAALTLGVEAKEIAKCCDSVMFCVSKGLAAPMGSILAGNKEFIA
                     KARRKQKVMGGGMRQVGIVAAAGIIAIEKMTLRLNEDHENAKYLACELNKIDGIEVNN
                     VNPDISMVFFKMSEDIIKEDVLIKEFFERNIKINKMENGEYRFVTHVDITKEDLDYVL
                     KTLKELIGVC"
     gene            42949..44724
                     /locus_tag="KR257_001454"
     CDS             42949..44724
                     /locus_tag="KR257_001454"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897789.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NFACT family protein"
                     /protein_id="HBH0030163.1"
                     /translation="MALDGLVIHSIVDELSSKLTGGKIDKIHQPEDDEVIFNIRNNKE
                     NFRLVLSASASNPRVYLTSNYQKENPLKAPMFCMLLRKYIQGGNIVEISQIGFERIIK
                     ISVESLDELKEKTVKNIMIEIMGRHSNIIITHGEENKIIDSIKRVPFSISRVRQVLPG
                     HDYSLPPEQNKLNPLDDISKDLFIKNLEELEGPIFKSIYSKFLGISPIIAKEICYRAG
                     VNQNAIIKDISDEQFDALHKVFCNLFNDINSNKYSPCIIIDKKVDKVVDFSCINLTLF
                     SDLSYINKDSMSRILEDFYRTKDIKDRINQRSSDLKKSISVKLDRLYNKLKKQEEELS
                     ESENADIYKIKGELITSYIYMVEKGMESIEVANFYDENCNDVTIELNKNLTPSENAQK
                     YFKKYNKMKHAKVEISHQISLNKEEIDYLENIILSIENCENLAELQDIKEELAKVGYI
                     KTQKKNSKKDTIPSTKPHEFVSSDGFKILVGKNNKQNDYLTLRLADNDDLWMHTKNIP
                     GSHVIIKCAGKEVPDNTVFEGAMLAAFFSKSKLSSQVPVDYTKRKNVKKPSGSKPGMV
                     IYETNSTIYVTPEEETVAKLKVKSE"
     gene            complement(44939..46591)
                     /locus_tag="KR257_001455"
     CDS             complement(44939..46591)
                     /locus_tag="KR257_001455"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861613.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC-F family ATP-binding cassette
                     domain-containing protein"
                     /protein_id="HBH0030164.1"
                     /translation="MLLVKVENLKKYYADKLILDIDKLEILENDKIGLVGSNGQGKTT
                     LLKAILGEIEIDEGYTYLTESYSYISQSENNIETCSHSKEKSLLNAPDKFEEHLSGGE
                     KVKLKIADALSNKKNIIIADEPTSNLDKKSIGVLEDMFKRHEGALLLISHDRRFLDEL
                     CTTILELEDGKLKAYKGNYTDYLMQKDEEVKRADFEYQEYVKEKKRLEKALLYKKALS
                     DGIRKTPKRMGNSEARLHKMGGQTNKKKLDSNVKAIKSRIDKLEVKNKPKVSKEMNIK
                     MQDGMEIISKNLVEVKDMTLKLENKLLLDNVSFKIKRGKKIALLGDNGCGKSTLIKEI
                     LADKNDNIKINNKVKVGYFDQNQSLLDEEKSVLYNTKVNSSFDESFIRINLSLFGFKG
                     DDVYKKVKVLSGGEKVKIALCKIILEDNNFLVFDEPTNYLDIKSMEALEKALINTDKT
                     MLIVSHDRVFVSHICNYIIEIKDAKIREFDCNYDEYTISRNKKTPSRENQIKKENLLV
                     LENRLTTVISMLSIEKDNLKKELYESEYNELLKQINKLKNSF"
     gene            complement(46890..48101)
                     /locus_tag="KR257_001456"
     CDS             complement(46890..48101)
                     /locus_tag="KR257_001456"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729399.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="uracil permease"
                     /protein_id="HBH0030165.1"
                     /translation="MKKTIMSLQHLLAMFGATVLVPILTGFNPSVAIFCAGVGTLIFH
                     FCTEGKVPAFLGSSFAFIPVILAAKEAYGGDLAYAQGGIIVAGLIYIIMSIIVKVVGV
                     NKIKLYFPAQVTGAMIVVIGLNLLPTAFSMASANFVIAFITLAIAILTNKFGRGFIKQ
                     LGILIAVFSGYIICLILRLVDITTITEASLFAIPNFTVPKFSLGAIVIISPVVLAVFM
                     EHIGDMTTNGAVVGKNFIENPGLNRTLLGDGFATIVAGCLGGPANTTYGENTAVLAIT
                     KNYDPSILRRTAIFAILLACVGKFGGFLQSIPGSVMGGISIMLFSMITYVGLKTIRDS
                     SCVESKINILIIAVILLIGLGTTYLSNKGISVGIPITSTVKITGLSLAAIVGIVLNRI
                     LNNQDFKVEEE"
     gene            complement(48385..48918)
                     /gene="pyrR"
                     /locus_tag="KR257_001457"
     CDS             complement(48385..48918)
                     /gene="pyrR"
                     /locus_tag="KR257_001457"
                     /EC_number="2.4.2.9"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001156491.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional pyr operon transcriptional
                     regulator/uracil phosphoribosyltransferase PyrR"
                     /protein_id="HBH0030166.1"
                     /translation="MVEKAQLMDEKAIARAITRISHEIIERNKGVENLVLVGIKTRGV
                     PIANRISKKIEQIEGTKVDTGDIDITLYRDDLEKIHVEPVVKGTYLDFNVNDKTVVLV
                     DDVLYTGRTVRASLDAIIDIGRPKSIQLAVLVDRGHRELPIRADYVGKNVPTSRHEII
                     SVSLLEIDGEDSVTIKE"
     gene            complement(49278..50225)
                     /locus_tag="KR257_001458"
     CDS             complement(49278..50225)
                     /locus_tag="KR257_001458"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003431188.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RluA family pseudouridine synthase"
                     /protein_id="HBH0030167.1"
                     /translation="MFYFLKVKVGDIMDEVKEFLVLEEEEEVRLDIYLAEQLGDMSRS
                     YIQKIIKDGKVKVNNKVEKARYLVKEEDNIVIEIPEPKVLEVLPQDIPIDIVYEDDDV
                     LIINKPQDMVVHPAPGNYENTLVNGILYHCKDKLSSINGVIRPGIVHRIDKDTSGLLM
                     IAKNNYAHNFLAEQLKEHTITREYEFICYGVVKEDKITVDKPIGRNPKDRLKMAVVKD
                     GKNAITHFEVVERFDKFTHMRARLETGRTHQIRVHALSINHPLLGDYVYGPKETKFKL
                     KGQTLHAKKLGFIHPTTKEYIEFNSELPEYFKEVIKKIK"
     gene            complement(50194..50640)
                     /gene="lspA"
                     /locus_tag="KR257_001459"
     CDS             complement(50194..50640)
                     /gene="lspA"
                     /locus_tag="KR257_001459"
                     /EC_number="3.4.23.36"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729400.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="signal peptidase II"
                     /protein_id="HBH0030168.1"
                     /translation="MLYILIIILLIGLDQLSKIWVLNNLVDVSTIPIINNVFHLTYVE
                     NRGAAFGLLQNNQWIFIIVALLATVFGLYYLNTRKVHIFGRLGIILIISGALGNLIDR
                     VRLGFVVDYFDFRIIWEYVFNIADVFVVVGTVFLCIYVLFFESKSR"
     gene            complement(50950..51729)
                     /locus_tag="KR257_001460"
     CDS             complement(50950..51729)
                     /locus_tag="KR257_001460"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416201.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="polysaccharide deacetylase family protein"
                     /protein_id="HBH0030169.1"
                     /translation="MKKIIWGICICLLSIVGVYTYNHNTHNQDSSKEAYSLNDNIKDD
                     YEDVIIKKGNEDEKILALTFDDGPDEDFTPQVLDILKKNDVKATFFVVGEKVEYNKEL
                     LKRQYDEGHEIGNHTFTHINVAKNSYSSVEKEITDTQNIIKSVIGVEPKIFRPPYRAM
                     SKSVCDIIVSKGMNIILWSNLDPRDWSNPGVDAIINTILTKVQNGNIILLHDYNTKRN
                     DKSQTIQALEVVIPKLKERGYKFVTVSELIQHLDKNKQVQK"
     gene            complement(51784..52266)
                     /locus_tag="KR257_001461"
     CDS             complement(51784..52266)
                     /locus_tag="KR257_001461"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729402.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TraR/DksA C4-type zinc finger protein"
                     /protein_id="HBH0030170.1"
                     /translation="MDTKKYKDKLLKERENLTNLVEDMKDNTLFGDTTKHTSEKYSSG
                     ELSSYDNHIGDMGTDLYMQNMQNSLINHEEGRLYQIDLALSKIENGTYGICDLCHNQI
                     DLERLDILPDTSLCNDCAKKENNLLGDAMQNPDVEDSNFYSEDLTNLTDLNKNGILRD
                     "
BASE COUNT        17145 a         9051 c         5641 g        20527 t
ORIGIN      
        1 cagcaattca agtagtattg gataggttct atcctatctc tacatatagg tttccctata
       61 tgctgactat tttagctact aactcatgac taaggtcacg agtgtgcgta gctatttttt
      121 aatcaagcat tatatttttt agtgataggt caactgttta agttttctac cactaaatcc
      181 ctcctctctt tcttactatt tttgaactta gtaagttttt attttattct gattaactta
      241 aatttacttt ttaaaactta tactatttct tatcattttt atcacttaaa aaagtttgaa
      301 caacttctgt gacttctgct aaatccatgt actttttaac tggatataca tctacattac
      361 aagttccttt taattcattt aacaattctt gacttgtgaa tatacagtca caatcagcac
      421 ctctagctga atttatatct gtattttcta cttcacattc tatacctaac tgctttagag
      481 ccttttggat tgtcattttt aataccattg atgaacctac accaaaacca catactgcta
      541 atatcttcat ttttcattcc ccctaatttt gcttatttat aagttctatt attgaacttt
      601 tatcaccatt aattattagt tttacatttt cttcctcgta catcatctct gatagtgatg
      661 ctaatgctct aatgtgagta gtgttatcta cagcagctaa taccataaat atatttactg
      721 gttttcctaa taaatcaact tcatcttcta ctattagtaa agacatagca agcttgttta
      781 ctccttcttt agaacttgca tgtggtagag caaatctatc agctaaaaca atatatggtc
      841 catatttctc aactgacttt atcatatttt ctatatataa ctcttctata gagttatctt
      901 ctaacaatgg ctttgaggct atttttattg cttctttcca atctctaaca ttttttatta
      961 tattgaccct ttctgcatta attaattcct ttaacattgg ttgatacatc tctccttcat
     1021 ctatcttgtg tattatgttt aataaatcag cttttagtgc ttcttcatta ttgataactc
     1081 cattttttct tatagcttgt attattaatt caagattgaa atacttctcg ttttctttta
     1141 cacttattag tttgttcata agtaattgaa catctgatga tgttaaaaga ggatttacaa
     1201 caattacgtt gtttacattt tgtatatcta tagttgtaat tatgtaatcg tagtatacat
     1261 ttacttcttt tagttgctta atggatacta tacctactat ttctatggtt ggtatgtatt
     1321 tatatagttg tatttccaaa ctctttgata ccataagacc attaggacaa actagtaaga
     1381 ctttatttct tcttagacca ttatccctag accctcttaa atatcctcca aaatacgctg
     1441 ctataaatcc tatttcttct tctcttatcc cctcaaatac aggaaactct tcttcattct
     1501 ctataattga ttttataatt ttataaagtg actcatgttt atacttagtc tcatctaaca
     1561 ttggatttct aataggaaac ttaaatcgta ttctgttgta agaagagtgg aggtgcctta
     1621 aaatattttt cttaaactca tgcttacttt ctaattttat tgctgtattt acttcaaact
     1681 tatctataag tttatctaca tattcttcaa caacatcttc cttaacttca ctatttaagc
     1741 tgggaagtga acttatgtaa gtgcatatat aggcttgttc attttcatta gcttcttcac
     1801 ataaaagttc tttacaatta ctaaagtaac taattttttt agcttcattt agatatttat
     1861 atgagtataa tgttttccca tctcttatcc ttttatttag aaattccaca aacttagtta
     1921 gatttaataa agaataatca gtaagtttta tatgtccttt tgtatcgaaa ctacttactt
     1981 cctcacttat agaattaatt tccagtacat tttcttgaac aattatcaga aacagctctc
     2041 taataacgta ttcatcacct ataattttgt actttccctt atactctaat cttaacccca
     2101 ttgtttgaag gtattttttt acatcagtta ttgtttgtac tactgtgttt tttgaaagta
     2161 acatttcatt tgttagtttt tctattgata ttttttcgcc aagtaatatc ttgtttaata
     2221 taaaagtttt tctgtaatca ctatctaaaa atttatcttc ttcagttgaa attattttcc
     2281 ttgcatcaca taaattacct tcaaatataa atttgtgttt tacatttttt atattaccac
     2341 tttttcctag ttgttcattt atagctagaa tatcgtaata aatagttctc tttgaaacat
     2401 taaacttttc ttgtagttct tgtgatgtta cattgttatt tttaataata aaatctaata
     2461 tttttttagc cctttccttc atactacctc cttaatttta ttatctatat tttctacatg
     2521 tagtgccata ccaaataatt gcacatgatt tagtattatt ttataatttt gcacagtcta
     2581 actctaatct aaaagaagac agtggtaaaa ttattaaaaa aatttgaaaa taacctatat
     2641 tatttataca aataaataag ttgatttcaa caaataaaag attaaactac attataatat
     2701 caaaataaga tataagtaat ctaaaaagca caattatata acaaaaaatt gctatattaa
     2761 aagagagcta tcacacataa attggaattt tttgtgtgat agctccattt ttatttattt
     2821 aaaatttatt ttttaggtct aagttcagct ttatctcttt ttacttcttc taatatttct
     2881 cttaaattat actcaacact agaaagcaca tcctctgcat attcaattga cccaattctt
     2941 atctcattgg ctattctctc agctctatca actatatctt ttgctctttg gtctgcttga
     3001 acaacaggtt cactggattc tacatatgcc tttactacat cttcagaatt tttctttaat
     3061 tcctctatat tatcttgata ttcttgttgt attctctcag cttctttttt cgcttgttca
     3121 actatatttg tagcatcttg cttagcttga cttattattt tatttctttc tttattaatc
     3181 catactgcct gtgttacttc ttctggtatt aaagttctta tatcattaat tattgctaaa
     3241 acctcatctt tatccactgt gcatttatgt gagaaaggga ttgtagaagc acttctaaat
     3301 atctcctcta actgctcaaa tagttcaatc atttctaaat ctatcttcat atatcaatta
     3361 cccccactag tttttttctt taattcttcc aaaacaatct ttggaaccaa attttttata
     3421 tcagcatcaa agagcaaaac ctcttttatt aaagatgaac ttataaatga atattttgta
     3481 caacttggta aaattatagt ctctatatct ggattaagct ctctattcat atgcgccatc
     3541 tgaagttcat aatcaacatc agcaccactt ctcacacctc taactaatgc tccaatccca
     3601 ttttcctgac agtaatttat taataaacca tcaaaagtca caacttttat attatttaaa
     3661 tggcttgtac ttttttctat aagttttact ctttcatcaa agctaaatag acccttttta
     3721 ttaggattat ttaatactcc tatttgtaat tcgtcaaata acttcgaagc cctgcaaata
     3781 atatctaaat gtccattagt aattgggtca aaacttcctg caaatatagc ttttctaggt
     3841 ttattttcca tattatgcct ccatcttata aaaagttaat gtagtatttc catatttctt
     3901 atctctagtt ttctccaatt tacatatctt atctggaaat aaatcattcg tatcatgttc
     3961 tacaactatt attccatctt cgttcaatag attagaatta tcaatttttt caatagcttc
     4021 tataaacata tttttataat acggagggtc cataaaaatt atgtcaaatt tactattttg
     4081 taatttaagt ttatctattg cagtcttaaa atcaaggttt aaaataatac tttcactttc
     4141 aactcttgcc ttttttatat tggacttaac aatatctatg ctttccttac tgatatctac
     4201 aaaagtacat gacttggcac ccctagataa gcactctatt cctaaagaac cagtcccagc
     4261 aaataaatcc agaacttcac tttccattat atatgaattt atcatattaa atagagactc
     4321 ttttactcta tctgtagttg gccttacatc ttcatttttt ggagtattta gttttaatcc
     4381 tctcgctttt cctgaaatta ctctcaatat gacaatctcc cttcagcaca ttattacatt
     4441 agtaatattt taacacaatt taaaattaat ttaatgaaat ttctttcaat gtatctttaa
     4501 atttatctat aatttctttt ttgagtgcca tgttttcttt taattgtaga ttattatctt
     4561 cacccaatat atatcgagct tcttgctgtg ctaacttcag tatttttata tgcttaaata
     4621 agtttgctac cttaagttct ggaagaccat gctgccttgt cccaaaaaat tccccaggtc
     4681 ctcttatttc taaatccttc tctgaaatct taaaaccatc attggtctct tccattatag
     4741 ccattctttg tctacataca tctgttttag aatcataaat tagtacacaa tacgatttat
     4801 gactacctct tccaactcgc cctctaagct gatgtaattg tgcaagtcca aatctttctg
     4861 cattttctat tatcattaat gttgcatttg gcacattgac accaacttct attactgttg
     4921 ttgaaactaa aatatctatt tctttatctt taaaaagtct cattacttca tctttttcac
     4981 ttgacttcat tttaccatga agcaacccaa gccttaagtc gtgaaaatat tccgctctta
     5041 actcctcaac aagttcaact gctgatttgg cttctatggc ttcactttct tctaccaagg
     5101 gacatacaat gtacacttgt cttcctgatt caacctctct tcttacaagg ttattatatg
     5161 ctctatctcg cttacttttt tcaatagcaa ttgtttctat tggctgtctt cctggaggaa
     5221 gttcatctat aatagaaata tctaaatctc catagagtat aagtgctaaa gttcttggta
     5281 ttggtgttgc tgtcattact aatatatcag gatttgctcc tttcaatgaa agtttgctcc
     5341 tttgcataac accaaatcta tgttgttcat ctgttataac taaaccaata ttattaaatt
     5401 caaccttatc ttcaattagt gcatgtgtac ctattaatat atcaatctca ttattcttta
     5461 tttgttccaa tactgtatcc ttttgttttt ttgtaagact acctattaat agacctacat
     5521 ttattccaaa atcttttaga gactcagtaa gtgaaatata atgttgccct gctaatatct
     5581 ctgtaggtgc catcaaagcg ccctgataac catttaaaac acaatttgca agtgctaaga
     5641 gagctactac tgttttacca ctccctacat caccttgtac caatctattc attattttct
     5701 ctaaattcat atcttgtata atttcatcta atgccctgtt ttgagcttta gtcagtttaa
     5761 atggtaaagc acttattatt ttttttaagt ctttacttgt ttcaaacttt attccatctt
     5821 ctttatttct gccactttta aatacaaaca accctagttg tagtataagt aattcttcaa
     5881 atacaattct atataaagct atttttaatg attccttact acttggtgaa tgtatgtttc
     5941 taactgcaaa atctatacta catagcctat atttttctat aattctttgt ggcatatatt
     6001 cttgtataat taattcttta tcttcaagta ctgttctaat tatactcata atttctttat
     6061 ttgtaacacc gtatgtaagc tggtacacag gcataaatct acatgtattc ttaggtgaat
     6121 tagtaagata ttctaattca catgatgtaa gttctaagtt attaaatttt ttcttaacct
     6181 tcccaaaaac taatattgaa tctcctggac gaaaagtatt ttttatataa ctcttattaa
     6241 aaaacactaa tttagccgag cctgtctcat cttttacatc aatctttgtt aaagtcatac
     6301 cttcttttgg gctaaatgta tttatacttg atattactgc ttttatcgta actttctcac
     6361 catcttctaa ttgtgctatt ttctttagat tatttctatc ttcaaattgt cttggaaaat
     6421 aatacaatag gtcttttagt gtaaatatac ccagtttatt taatttatct gcttttttag
     6481 gtcctattcc cttaacatat tgaacatctt tatataaatc caacaaatat atcacctact
     6541 acacaaaaat cctgtacaac caattttata aaagctactt ggtcatacag gttcttataa
     6601 tcattattca actgaaatta agtaataata aagaggttgt cctccataat ataactctac
     6661 atctacatct tcaaactttt cttctaaaga agtacgtagt tcatttgctt gagattctgt
     6721 aacatcttca ccaaagaata atgttattat agcagtatct tcatcaacca acttttcaat
     6781 aaggtttgat gttacttcat ccacataatc tcctgctgat aataaattcc cttctgcaat
     6841 tccaattata ttaccttctt taacatcaat ttcgttcatc actgtatccc taacagcaaa
     6901 agttacttga cctgatttaa ctgagtttaa agcattcatc atagcttctt tattttcatc
     6961 ttcgcttaat tctccattaa aagttactaa tgcagcaaat ccttgaggcg tattttttgt
     7021 aggtataact attatatttt tatcactcaa ttcttttgcc tgattagcag ccattattat
     7081 attgctgtta tttgggaaaa taaatatatt tttagcattt atatgcttta tagcattcat
     7141 aaaatcttca gtacttggat tcatagtttg accaccttct attatatggt caactccgaa
     7201 atctttaaat atatttgcca aaccttcacc catagaagta gctataaacc caaactcttt
     7261 ttcttcttct aaaggttcac tatcattttc tttcttttct tctacatcca gtaatgtatt
     7321 ttcatgttgt aacttcatat tttctatttt tatagttaat aattgaccgt actttagagc
     7381 ttcttgaagt acatttcctg ggtcattagt gtgtacatgt acctttatga ctccatcatc
     7441 tccaactact gctaggctat caccataagc catcattatg tctcttattt tagtatcttc
     7501 taccttagaa ctttctaaaa taaattctgt acaatagcaa tattttatat catctgtgct
     7561 agtagtactc tttgcaaaat ccatacttgt tgaaatatta gtatctaggt caacattttt
     7621 tatttctatg ttatcgcctt ttatagaagc taacattcct tcatatataa gtacaagacc
     7681 ctttccacca gagtcaacca caccagcttc ttttagattc tttagaaggt ctggagttct
     7741 ttctaatgaa gaatttgatt ccttcacaag catacttaaa aactttacta catctttctc
     7801 ttttttcgca gtttttattg caaactctcc actttctcta actacagtaa gtatagttcc
     7861 ttcaattggt tttattacag ctttatatgc tgtgtctgaa ccatttttaa aagcttttgc
     7921 taaatcttct gttgataatt tactttttcc ttctatagat ttagctatac ctctgattat
     7981 ttgtgaaagt ataactcctg agtttcctct agctcccatt aaagaacctt tagataatgc
     8041 ttttccgata tctgatatat tatcattttc aacttttgct aattctttta aggcataaga
     8101 tattgttaat gacatattag ttcctgtatc tccatctggt acagggaata catttaactt
     8161 gtcaactaac tctttattgt tttggagatt gtttgcacct gaaataaaca tctcccttaa
     8221 ccttttacca tctatatatt gaatcatttg tttcctccta tgaaattact taactcttat
     8281 tccttgtaca ttaatatcaa ttctagtaac tcttacgcca gtcatttttt caactacata
     8341 ttttactcta tctattatat tattggcaac agtagatata tttgtaccat attgtattat
     8401 aacataaagt tcgattgcta tggcatcttc ttctacttcc tcaactctta cacctttagt
     8461 tgcgttctcg ccttttaata gctctactat tcctttagac ttatatgcta aacctactaa
     8521 gccataactt tccattgcag ctctatatac gacttgagct attacttgat tatctatttc
     8581 tatatttcca tattgattcg ttacctttgc actcatggtt gaccccctta agcttatttt
     8641 tattaaaaac atttcttaat ttatttttta ctatttttac ttatttatta tataaaatta
     8701 taatcatatc atactataaa tatggtataa tttaaaccta gaaaagtttt tggataaaat
     8761 ttcttctata gtatatatat tcaaagaaaa ataataatta ttttccaaat atatttactt
     8821 tatataaaat tatatatata attttatatg ataataagaa attcttcaat atgtgtaagg
     8881 caaatatata tttctattgc aaatttttgt tatttatgat aatataaata tgtttttagt
     8941 ctttaaatag ttatcatttt aaggaggtgt gcgtagatgg caaaagtatg tagcgtatgt
     9001 ggtaaaggta aggtttctgg aaaccaagta tcacactcaa ataaacataa taaaagaaca
     9061 tggtcagcta acttaagaag cgtaagagcg attatagatg gagctcctaa gagagtaaaa
     9121 gtttgtacta gatgtttacg ttctggtaaa attgaaagag cttagtaacc acgtttaaaa
     9181 gcctacttcc gtaagtaggc tttttaattt aatcattttt actctttctc ataaatttta
     9241 ggattatact tgaaatccat tttggtaatt ttattgttac tactttcatc aatactcacc
     9301 ccacacttta tagttaaaac tattttaaca aaaaaataat aatgctccac atccaataag
     9361 tattaatgcg gtaagtgctg accaaatcca gccaggaagc aacattgaca gaattacagc
     9421 cattcctgtt gctagacaaa gtattcctag caatacctta gacttgttat ttctcatgga
     9481 acacctccac atagaacctg tatctataaa tattttcata ttcaagttta tgcgacagtt
     9541 ttccatttta gaccaataaa cacattatgt aattttaatt tttcatacta gaattattac
     9601 tgaactccga tatagattct acaatatcca aaattccttt ttttctactt aacctttcag
     9661 gtccactata taaaacaact ggtataactt taggaagttt aaaattttta tcttctattt
     9721 cttcaaggct ttttttcata ataaaacttt tccaaatttg ttctctatac gatttcaatc
     9781 ttgggacaat ttcagtatcc atttctgttt gaaattctaa cactatataa tgtgatactt
     9841 tgccactttt agaaaatacc ttataaatta tatcaacttc ttttccttta tattcacata
     9901 taaaagatgt ttctaactct atatttttaa gagttaattc ttttgctatt gagacacttg
     9961 taaaattttg aatcaaactt aaaaaacttt ctttatctga atacattctt ctgtactctt
    10021 ctcgtttttc attgcttctt tttaaattca tacagttcct cctagactat agaccctcta
    10081 ttttttagta aagatagtct ataaatttta ttttttaatt ttcattagtg agtattgaca
    10141 gttgtgtgta aaatatccag taaagatatt tttttatatt tttattaaaa gatataaatt
    10201 tttatatttt aatgtattga catttacgtt gcgtaaaagt gtatatttaa tttataggag
    10261 gtactactta tggaatatac agttcaaaaa ttaagtaaac tagctggtat aagtactaga
    10321 acacttagat attatgatga aataggtctt cttaaaccac ttaaaataaa ttcttcaggt
    10381 tatcgtatat atggtcaaaa tgaagttaat aaacttcaac aaatactttt ttatagagaa
    10441 ttaggaatta acttagaaaa tataaaaaac attataaatt caccaaactt cgatagttta
    10501 agtgcgttaa aagaacacca taataaatta ctagccaaaa gaaagcaaat tgatttacta
    10561 atagaaaatg taactaaaac tatagctctg aaggagggaa aatacactat gacagatata
    10621 gaaaaatttg aaggttttaa agaaaagatg attgatgaaa atgaaaaaaa ttatggaact
    10681 gaaattagag agaaatatgg taaagatatt atagatacat caaataaaaa acttaaaaat
    10741 atgtctaagc aagattatga aaattggcaa aacctaaata tcgaaataat tagtaaactt
    10801 aaaaaagctt ttaaaactgg tgatgcctct agtgaactgg ctcaggaagt tgcaaaatta
    10861 catcataaat ggttgagtta cacttggaac acatactcta aagaagctca ttcctctcta
    10921 gcacagatgt atgtatatga tgaacgtttt acatcatatt atgatagaga acaacctgga
    10981 ttagctaagt ttttaaggga tgctatagta atatatacaa gagataaata atataaaata
    11041 ataaaggtgg tgtctcaaaa tgaacttttt agttcatgag acactctttt ttgtatgaaa
    11101 tcagatatat ttttatcatt ttatcaatga aaaacaggtt tctctctcta ttttgagaca
    11161 gaatctttat tgtataataa ttataatcaa tacaaaataa taacaaatta tacaaaactt
    11221 acttatacta tttatgctaa aaacaaaaaa tattttatta aagtttttaa aacttatgta
    11281 atataaaaat ctatactata gacttgatta tggaaagaaa attatcaaaa tcattacaat
    11341 tagatatact atctctaata tcattgtcat gaattatctt taaaaggata tcataaatgg
    11401 agtttatttt tatataatca tctttattta tagccaacat catgattaat ttaacagtag
    11461 aatcttcact ccaatatatt ggttcatcca atatggaaat acaaatctta gttcttatag
    11521 agcttaattc cataggatga ggtatagcta aaaaatcatc tatattggta gaagataaac
    11581 tttctctgta aaatacagat tcagcaaatg atggaaatac aatttcactt tgagttaatt
    11641 tgttgcacat caactttata agctcatctt tatctttgat tttaggatta acaataaata
    11701 aatttttatc aaagaaattg tccaaaagat tactataaat atgggaatta ttagtgattg
    11761 acttagatat attctctata tcttttttta atagttttaa atccactaat acaataggaa
    11821 tactatcatg atttaaagga attgtcgata ttattatatc tacatctgac aattcactag
    11881 ctaaaaattg attaaatgat agacattgaa gtatatttat tttatcatga aaaactttgt
    11941 ttaattgaac ctctaataac ctacttgaac cataccctga accacatact aatactacgt
    12001 ttttacactt aatattactt tgaaaaaatc tctctattcc agcacctata tgcagggata
    12061 catatccaat ttcatcttct gttaaagagt aaatactatt tttaaaaact ttttctatag
    12121 catttaaagt tatttcaaat gctaaaggat aattactctt tattgtattt ataaggggat
    12181 tcaccttatt taaattataa gatttagaat tgagaattga tttaaagtgc agtactaaat
    12241 catcaaataa tacactatca tttctaaggt caaaagtata ttgattgttg attacttcta
    12301 aaatttcttc aacatactct ataattttag tatctaccct attggaaacg ttatccaaaa
    12361 gagaactttt agttataaaa tgattatata gataaactct gtctgccttt gaaataatta
    12421 tagtatattt actctcaata taattaaata tattttcaac agttgtattc gattgaaaat
    12481 ctgttaaaac aacatctaaa acattatcta agcagtaacc atcaagtatt ctacttacag
    12541 taatagctaa atggataata aagtttttta gattaaaatc taggaaattg atattaaatt
    12601 tattaatttc acttaacact accctttgaa gctctattaa atctacatta ttaaataatt
    12661 ctatttctct atctgtaatt ccaattatat agttttcaaa attcctattt atcatattat
    12721 tagaaataca tcttcgaata tctatttcct taccttcaac tttaactcca taatatggct
    12781 tagaaactaa tattaaatta tactttgaca aaataggctt tattcttttt atgtcattta
    12841 gtattgtaaa tttactcaca tacaagctat tagctaaatc ttctagtttt atatatgtat
    12901 tgttatagag aatatatttt aaaatatatt gatttctttc tataggagaa tctggtattt
    12961 cacttgaatc cataatatca tcagatatta atgctagata ctgttggtat aatgctaaat
    13021 taagaatatc tatataatat ccttctcctt tttttatttt aataatagca ccatttttct
    13081 ctaaagttcc atttatagaa gtaatatcat ttcttatagt tctctcactc acttttaaat
    13141 gattacttaa agttttacaa gtaattttat catcactttc atttaataat ttaaacaacg
    13201 tgagcaatct cttgtgcata aatatccccc cttatagaat ttcttctaaa ttatactatt
    13261 tacactcata taatacaatt actctaataa aattgtatta taataattta tttccacttc
    13321 tatatggaaa ttagttatta tcataatata aatttccatg tcgaagtgga aattagttat
    13381 atttaattta attaggataa tgattacaat ataaatataa gttaagacat tatgaatgga
    13441 gtggaaaaat atatggtact acaagaaaaa tatatattta tagataaaga cttaaaaagc
    13501 aaagaagaag tattaaattt tattgcagat agtgcttata tactaggtat tacaactaat
    13561 aaagaggctc ttttaaaaga ccttctaaaa agagaaaatg aatttccaac aggaataaaa
    13621 gatggatttg cgatacctca tacaaaaagt gtaaatgtaa aggaagcttc catactctat
    13681 attaaaacaa ctaacgagtt agagtggaaa actttagatg atagtaaggt tagatatgta
    13741 tttagtttgt tagccccaca taaaaatgaa ggaaatatac atttgaaaac tctatctaaa
    13801 ttagccacat gtttaatgga ggatgatttt acaaatgaag ttaaaaatgc tagtgatgca
    13861 agtcatttag taaaatatat aactaataaa atgaaggagg aataattatg aaaatagtag
    13921 caataacatc atgtatagca ggattagcac acacacctat ggcagcaaaa gctttagaac
    13981 aagctgcatc aaaaatgggt catgaaatca aagtagaaca acaaggtgct atgggacgag
    14041 taaatactat aacaaaagaa gaagcacaag atgcggactt tatacttata gcatctgacc
    14101 aaactatatc tggaatggaa agatttgatg gtaaaaaggt gataaaagtc aaaataggta
    14161 tagcgttaaa aaaaccagaa gctgtcttaa caaagtgtat agaagctatt tcttaataaa
    14221 aaaatctcac tctaatatag aatgagaaaa atcaaaaatt aaaaaattgt ctaatgtaat
    14281 tataacatat tatcaaaaaa tataacaaac ttatatagga ggattaaaaa tgagtaaaaa
    14341 aaataaatct cttttaagtg aacttaaggg acacttaatg acaggtatct catatatgtt
    14401 gccacttgta ataggctcat ctttagttgt agctatccca aagcttacag ctttagcaat
    14461 gggtataaca agtttagatg cttataaaaa tgtatctggt ttttatcata ttctttactt
    14521 aatggaacaa gttggttgga ctggcatagg tctattaaat acggtattag caggatttat
    14581 agcattttca ataggtgaga aaccagctat gggtgcaggt tttattggtg ggctcatagc
    14641 aagtaatact aatgcaggat tcttaggagc agtaatagca ggtttctttg ctgggtatgt
    14701 ttgtaagttt ttaaagaaaa aaattaaaat atctgggtca gcatcaggaa tgatgccact
    14761 tataataatg ccacttataa cagttggatt aactggtttt ttaatgagtg ttgtattagc
    14821 aggaccttta ggaaacataa atacttcatt aaatgcttgg gtagctgaaa tgtgtcaaaa
    14881 tggaacaaat tcggtggtat tggctttaat tttaggcgca atgataggat tcgatttagg
    14941 tggaccagta aataaagcag cttggatggc aggaaatgca ttattgttag agggaatcta
    15001 tctaccagcg atattggtaa actgcgcaat agttatacct ccactaggat atggtttagc
    15061 tacattcata agaaaatcaa agttttccaa tgcattagct gaaacaggaa aaggcaatat
    15121 agttatgggt ataattggaa taacagaagg tgcaattcct ttcactttaa caaatccatt
    15181 aaaattagtt cctgttaata tgataggatg cgctttgggt gtaggattat cagctttgtt
    15241 aggtgtacat gctataatgc ctccagttgg tggattatat ggatttatat caataggttc
    15301 tggatgggct tacttagtag gtgcaatatt tggagcttta gtaatagcaa tattatcaac
    15361 aactttagta gacttcaatg aagatgaaac tacggaaaat acagaatttg atgaaataga
    15421 gttagatata atgtaaatta aaaacttaat tttagataat tgagaattga gtgtactctc
    15481 aattctcaat taaattttgg gaggattttt atgaaaaaga caaaagtaca tgtagttcca
    15541 cacagtcatt gggatagaga atggtatttt acaacatcaa ggtcaaaaat atatttaatg
    15601 aaagattttc aagatatatt agacatattg gaagaaaaag aagactttaa atactttact
    15661 atggatgcac aagcttctct cttagatgat tatttaaaat ggagacctca ggatgaatat
    15721 agaataagag atttagttca aagaagaaga ttagttattg gaccttggta tactcaaaca
    15781 gaccaattgg ttatatcagg agaatctata attagaaacc tttactatgg aatagataga
    15841 tgcaatgaat ttggtgaacc tatgagggtt ggatatgtac cagattcttt tgggcaatca
    15901 gctcaaatgc cacaaatata cagaggtttt ggaatagata gttcattatt ttggcgtgga
    15961 gtttctgatg atatggtaga tacaacagag tttatatgga aaggttctga tggttcaaaa
    16021 gtattagcag ttcaaatacc atttggttat tactatggag gtaatatacc agaagatgat
    16081 tctgatttaa aagaatattt aaaagatata atcggaaaac ttaaggttaa agcttctact
    16141 aataacgtat attttccaaa tggatttgac caagcaccaa taagaaaaaa ccttcctgat
    16201 atattaaaaa aagctaatga aatagataat gaaaatgaat acgaaataag tgatatagaa
    16261 aactatatag attcagtaag aaatgaaaga aatgaattta cagagcttaa aggtgaattt
    16321 ttaaatgcta aacatatgag aatacacaaa tccatattct cctcaaggtc agaccttaaa
    16381 ataatgaata acaaattaga aaattatatt acaaatgtac ttgaaccatt attaacatta
    16441 agttattcac ttggaaatga ataccctcac ctagttataa aagatatatg gaaacttatg
    16501 tttgaaaatg cagctcatga cagcataggt tcttgtaata gtgacacaac aaatgaggat
    16561 gtatacacaa gatacaaaca agccagagat ttgagtataa atttattaga tttgcatatg
    16621 agacttataa gtactcaaat caaaaataat aatgaagaaa taacattaac agtattcaat
    16681 ggattcccag aagtcagaaa tgaagttgta gaatttgata cttatattcc aggtcaagat
    16741 tttgtgataa agaataaaaa tggaaaaatt cttaattata taataaaaga aaaagaagat
    16801 attacaaatt atatattaac tcaaacaata agattaaacc caagtaaaaa aatatatata
    16861 cccaaaactg tatatagagc aaaaattgca ctttcagtaa aagatatacc accaatggga
    16921 tatactcaac tagtttttga attggatact aaaaataaat gtgaaataga aacaagtaat
    16981 tgcaaggaaa tagaaaacaa atactacaaa ataacagcca ataaaaatgg ttcattagaa
    17041 atattagata aagaatctaa taagacttat aaaaaccaag ctgtaattga agacaatgga
    17101 gatgatggag attcatacaa ctattctcct ccaagaaaag atatttatgt ttcatcttta
    17161 gattctgtat cttcagtaga agtgctaaaa tcaaacattc aagaagaaat gatacttaaa
    17221 tattcattga ccataccaac ttcactggaa gaaagggcta taggtaaagt ttctgtgaaa
    17281 atgccagtaa caatgaaaat caccttagaa cctaaagaac aaataattaa gtttaatgtt
    17341 aatataaaaa ataaccaagc actatctcat agagtaagag ttttatttaa tacagaaata
    17401 gcatctaagt tttctatagc agatcaacaa tttggaataa tacaaagacc aacagtatta
    17461 gaaaaagacc ttgcattgtg gaaaagagac aattactcat ggcaagaaaa acctataact
    17521 atcgaaccaa tgcaaagttt tgttacttta gaggatggac aaagaggaat agcattaata
    17581 actggttgtg taagagaata tcaaatagtt ggtgataatt tagatacaat agcattaaca
    17641 ctattcaggt catttggata tatgggaaga gaaaatttac tttatagacc aggaagagct
    17701 tctggagaaa aaataatagc aacaccagat gcacaattac ttaaagagtt aaactttgac
    17761 tttggtcttt acatatataa caataaattt gatgaagcaa atgtagctaa tacagctaag
    17821 agattcttaa cacctataca aatatatgaa tatgctgatt ttttaaatgg tagacttata
    17881 tttgcattca atgacgaaaa acaaatatat gaaaatgaat ttagtttgat gaatgtaaat
    17941 aattcaaatt tcacagtaag tgcaataaag aaagaagaaa aaggagatgg aattgtagtt
    18001 agaatcttca atggtatgaa aaatgaggat gctaagggaa gtcttaacat caataaaaat
    18061 gtcaatgatg cttatagtgc aatgctcgac gaaatctatg ataatactag caagcttaaa
    18121 gtaaatacta aaactgtaga ggtaaattct ttatcacatt gtaaagtaca aacaatagta
    18181 attaaataat ataaaatagc ttatacaaga tttcaaaata aattgctagt actatgttaa
    18241 tagtaaagcc agatattatg ctatttataa gctctgtaac actaaataac attttgtaaa
    18301 ataaaaaggt gaaccttgta tattaggatt cacctttttt aaataaatca acattctgtt
    18361 ttaaaataac atttataagc tgttttgaaa taatgcttac aaattatttt aaaacaatac
    18421 ctataaattt ttatttaaag aatacacata aatatttcca gattctttta ttctatagac
    18481 tttataatta ttaaagaagt ctaatctaat ttttgttaaa agtaattgta actttgaata
    18541 aatcaccatc cacacttata ttcatcttac caccctgtaa ttctataaaa ctttttgcta
    18601 tcgctaaacc aagaccagaa ccttctgtgt tacgtgattt atctcctctt acaaatctct
    18661 ccattatatc atctacacta aaatcaatct cagatgcaga catattttta agcataatat
    18721 ttactttatt atctgtttct aaaatatcaa tatacactct tgaatttggc attgcatatt
    18781 tgcttatatt tattataaga ttttcaaata ctctaaatgt acgctgacta tctaatggta
    18841 atattatttt ttcattagaa aagttattct ttactattag agatgaatct gcaagtttgt
    18901 catctaattc taaaagtgtc tgcttcatta gagatacaat atccacattt actatattca
    18961 aataaacatc tccactattt gccttgctta cttcaaacaa atcttctatt agatgttgca
    19021 atctttgtga ctttctgtct aatgtatcaa tatacaactt acgattttca tctgttatac
    19081 tttcatcttt taataaatct atataagtga ttatagatgt tagaggtgtt tttaagtcat
    19141 gtgatacatt tgatataagc tctgttttca tcttttgact cttaacctct tcgtcaacag
    19201 cttttttaaa tccagtttga atatttccta attcatcttt tataggatta aaaaatccta
    19261 aatctttttc catatttaca tctaagtttc catctgaaat tttctttgta acatctaaaa
    19321 gttgattata ttcatatatt gtctttttag agtaatctga cagtatctta aataatacta
    19381 ctgaatatat taatgcgagt attattccaa agaaccacat actacacatt ataactataa
    19441 tcaataaatt tattcccaaa attgtaacta tagttttatt tggcttttct ttcagattta
    19501 ttgttctaat ttgattaata actgcttttc ctgctttttt taaccataca aaaaacattc
    19561 ctgtcacagt atgttttgta aaatactctc ttattccaac atttaaaatg tgttttaaaa
    19621 gtattataaa tacaaatatt attgagaata ttacaaacca ataagttaaa ttcattaaac
    19681 ttaccaatat actagccatt ttagcactta tgtcattgtt tataaggtac tctacataat
    19741 tcccactcaa ggtattactt attataacag taggatataa atctacaagc ccctgtataa
    19801 tagcaagagc aataaagagt atctctaacg gtattcttga taatgtatca aatcctagca
    19861 actctttaga ttttctatat gggaatgcta aagctacaat aacaactata gctaatataa
    19921 tttttaaaat cattccagaa atcttataat aagaattatt ttctacattg cttatatatg
    19981 aaattatacc atcatcaaaa taagtatttc cataaccata ctctacacta tcacctttac
    20041 ttattacttt aggtacagca tatactaatg ttatattttt tattggagat aacttatatg
    20101 aaattgaatt tcctcctaaa cttgtatcca ttaaatcttc tcttgcttta gataacaaca
    20161 tttgattaat aattttttga tttactccat aagaatccac aatatttact tttccatctt
    20221 tatcaaaatt cattacaacg tagaatctat agttttcttt tatatctgta atctgctttt
    20281 gtctttcctc atcattcatt tctgtatttt ttgactgatt ttcattagaa ttttcttttg
    20341 aagcatcatt ttttgttgta tcaagtactc ctaattcttt attatcatta aaaaattcaa
    20401 aattgctttc tttatcaact aaatagtact ttaaattctt tcctgacgct ttaatgaaat
    20461 gctcccaatt ttcaaagttt tcattaaaat ctgcattaat actatcatct gtataataag
    20521 tttctgaacc atcataagta tctttttctt tacttacatt ttttatatag ttcatagttt
    20581 cttcattgat aaatagcttt gatggttgta tcatcttacc ttcttgttct tccttcatat
    20641 tatgatataa aacataactt cctttatata tactatctac aaagctttcc tgttcaaatg
    20701 gattctctgc tccaccttta gcacttgctt gtatagtaga atattgacta atcataccta
    20761 atgatgctga taacataagt ataaaaacta taatagtaac tatatattta tctttaaatt
    20821 ttttcaattt tgtatccaac accccacacc acctttaaat atttaggatt ttttgggtca
    20881 atttctatct tttcccttat attcctcaca tgtaccataa ctgtatctgt atttacagca
    20941 ttctcattcc aaactctttc atatatttca tcagcagaaa aaactcttcc tgcatttctc
    21001 ataagtaaac ttagtatttt aaattctata ggagttgttt ttatatactt tccatcaata
    21061 ctaacttctt ttgtattttc atttaattct aatccgccta ttgcaaacac actatcgtca
    21121 ctttctacct tttgctcttt atttccaacc atgtttagat acttagtgta ccttctaagt
    21181 tgtgaattaa ctctagccaa tagttctaat ggcttaaaag gttttgttac ataatcgtct
    21241 gctcctatat taagccccat tattttgtca acttcttctg attttgcaga tagcattatt
    21301 actggaaaat tatagttttc tctaagcttc attgtaagtg ttataccatc cattttaggc
    21361 atcattatat caactatagc taaatgtatt tcttggtttt ctataacctt aagaccttct
    21421 aatccattgt atcccttaaa aacattatat ccttgattta atagatatat ttctatagca
    21481 tctgctatct ccttttcatc ttctaccacc aaaatattat atgaattcat tctaatctcc
    21541 tttatattaa tttataaatt ttctttacat atatgattat acaatatgat agaagttttt
    21601 ccatttatat atatatttat atcttttgtt ctggttattt gtatttaatg tccatcttag
    21661 aaacctcctt ctagtttaaa tttaatattt tttcattttg ttttatatac ttaatattaa
    21721 aattaaaaac ttaagatatt acatatactt ttctaaagat tttctaaaga tttaaatata
    21781 tttaaaatta atatacaaaa aaaagtagtt cttattgtat taattaaatt aatgatttga
    21841 aatataaaat taatatcaat aaaacctact ttttaatttt ttaaatattt atttttaatt
    21901 tattttgttt ttaatttact tcgattttaa aatgtccttg acttttattt tataaatgta
    21961 catatttctt ctactggttt tttagatgga ctcttcaaat tgtcctctgg cactccaaga
    22021 gctaacattg cacctaaaaa atactctccc ttttcaaaac cagtttctgc ttctaaaaca
    22081 gcttctatct catctgctgc atagttttga cttgtcaacc aacaagaacc atatccaagt
    22141 tcaattgctg atagtgtaaa gttttcaatt gcagcaccta gactctgcat acctggattt
    22201 cttataaata atttatctat agtctcctta ggtgcatcta taagctctaa ttcataatat
    22261 cctgatggat tatatacctt tgtaaaaact aatactaaaa ctggagcttt taagtaaaat
    22321 agtgtaaaat ttttaacaaa ttttctaaat ctattagcct tatccactga tactttatcc
    22381 atttctacaa gtatttcttg ttgcttttta gttatcacat ctgctatctt ttccattaaa
    22441 tcacggcgtt ttataacaac aaaatgccag ttttgaatat tcttgcctga tggtgctgca
    22501 cctgctgctt ttatcatttt taaaatatct tcatctgata catcttgatt tttaaacttt
    22561 cttacacttt gtcttttaaa aatagtatct tgtaattcca tttttaaatc cccccataac
    22621 ttttttatta ttttaatata atttttaaac tcatcttatt ttaatatatc atgttctaac
    22681 aaatctttaa atgaatctat aaaataatca tatacatcta cattcccaaa cccatatttg
    22741 gcatatataa aaggtatacc tacaaactta gcactatttg catcaccttg cgtatcacca
    22801 acatagattg gatttattaa tttatttctt tcaattataa gtttattatt ttctccttta
    22861 tgcaaaccag tattaccagg acattcaaaa tctataaaat actgttctag tttatgtgct
    22921 tttaaaaaag attctatata tccagcttga caattactta ctataaataa tttatatttt
    22981 ttagatagta atttaagagt atcttctata tcatcaaata atttagctcc attttcagat
    23041 aaatagtcac attctttcaa agaacattca ttcaataaat tcattctttc ttcttcactt
    23101 aaatttggaa ataaacgatt tgctatttcc tcaaaagaaa gccccataag acttctaaat
    23161 aaatcttttg tgacacttaa ttctatttcc ttatgctcac ttaaaacatc ctgccagact
    23221 ttgcatactt cttcagttga atcccacaat gttccatcta aatcaaaaat aatactatct
    23281 accacaaaaa atccccctta tgtcaaagtt tattatatat ttataattat atactaaaaa
    23341 gcagatacaa tcataaatat attttacttg attgtatctg ctctacaata taaaaccaat
    23401 tgtcaaaatc aaattttata aatttctaac tacaagtaca cagccttgct ctactttaat
    23461 cttacaagaa ttactcaaca taacatttga tattccaata ggtacagagt atttcatata
    23521 ataattatcg agagggtatt ctaagccagt aagtgttaca cccttagcat caccatttat
    23581 agctattaca gaaatagtgt cccctgggtt tccatacaat gaaatttcct cattttcaac
    23641 tatatacatc tcttctttat cagaaagtat cctagaatat ataccatctt cttttaaata
    23701 atataatagc tttatatttg caagagtgtg gtcaatcctt ccccctaaag caccaaaaaa
    23761 atcaatatga tttgctttaa gtgtcttagc taaaaaaaga caaagctctg tatcagtctc
    23821 atctttttta gatggaaatt tttcaaattt aacaccttta tttttataga agtttatctt
    23881 ttcttcttct actgaatcta aatctcctaa tatataatct ggcattattt ccattttata
    23941 agtgtgattt gcccctccat ctgcacatat tatgcagtca taacattcct taattataat
    24001 atctcttgta acttcgtaat cttcaatttc gccatttaaa acaatacaga ttttcattat
    24061 taaatttaaa ctaattcttc aagagaagca ttctttctaa ataaattaac tgtttcttga
    24121 atgtcatcac ttccaaatat tgcagaacct gctactatta cattagctcc tgcttgtaca
    24181 acttcggcta cgtttttagg gcttatacca ccatcaactt ctatatcaat gtttaatcct
    24241 tgactatcta taatagcttt taactcttta atcttatcta aaacacaagg aataaatgat
    24301 tgtcctccaa atccagggtt aacagacatt aataatacca tatctaaatc agatagtaca
    24361 tgtttaatcg tatctactgg tgtagctgga ttaagtacta caccagcttt tattccatgt
    24421 gattttatat tttgtatagt tctatgtaga tgaacacaag cctcctggtg aacagttatt
    24481 atatcacatc ctgcttttac aaattcttca atatactggt ctggattttc tatcataaga
    24541 tgagcatcaa ataccatatt tatattttct ttctttaaac ttttgactac aagtggtcct
    24601 aatgtaatgt ttggtacaaa gtgtccatcc attacatcga tatgaagata ttcacatcct
    24661 gcactttcta cttttcttac atcttctaat aattttgcaa aatctgctga taatattgat
    24721 ggtgctaatt taatcatgtt tctaatacct cctactatta ttttgtctta tttcatgtag
    24781 cagctgtata taactatcat atctttcttt agatatttct ccatttgtaa cagcttcttt
    24841 tatagcacaa ttaggttcat tttcatgaat acactttgaa ccaaacttac aatcattaaa
    24901 tttatcaaat tctataaaat aatctttaag ttcaacttcc tctatatctt caagtgcaag
    24961 ggaactaaaa cctggtgtat ctgcaaccat tccaccaaat tctaatttta aaagttcagc
    25021 gtgacgagta gtatgttttc ccctttttat tttatcactt acaactcctg tttgaagttt
    25081 aaaattttca tctatttcat ttaataagct tgattttcca actccagatg gtcctgcaaa
    25141 cactactaca ttttctttta attcttcttt tactttatct atatttaact tagtaatatt
    25201 gcttacagga atgactttat aaccactaag ttcatatata tttttaacag tttctaatgt
    25261 atcattatca tctaaatctg cttttgtaag gattattaca gtttctaaat tttctttttc
    25321 tgccaaaact ataaatctat ctaaaagaga taagtttggt ttaggatttt ttattgcgaa
    25381 tactattaat gctttatcta catttgcaat aggaggtctt ataagttctg tatctctact
    25441 gtcgatttct tctaagatac cctttttttc atcttcatca acaatgctta ttttgactct
    25501 atcaccaacc aaaggtgtta ttttctgctt tctaaatatc cctctagcct tacattcata
    25561 aataccatta taagtatcta cataataaaa tccactaatc ccctttataa tttttccttc
    25621 tagcatcaaa tgcctccctt tataaaattt atataaacac atactgttta tgagtagtat
    25681 atcgtgttat tctttcctat ttttatataa taccacattt tttttaaata acaaatcctc
    25741 cgtttggact aattacctga ccagtgataa aatttgattt gtctgatgcc aagaaaatag
    25801 cacaatttgc tatatcttct ggagttccta gcctcattag aggggtttct tccacaagag
    25861 cgtctatatc ttcctcatta tatccagata acatgtcagt attaatgaca cctggagcta
    25921 tgctatttac tctaatattt gatggtccta cttctttagc taatgccttt gtcataccta
    25981 ttatacctgc ttttgttata gaataatgca cttcacaaga cgcacctgat ataccccaga
    26041 ttgaagatat attaattata tttccttttt tttctgatat catgtatttt aaagcaactt
    26101 gtgaacaata aaagcttcct tttaaattaa tattcatcat attatcccaa tcttcatcag
    26161 ttatatctgt aaacaactta tcttgactta caccagcatt gtttacaagt acatccaatc
    26221 ctccaaattc ttttatacaa taatctacca tatcctctac atcttctcta tttgaaatat
    26281 tagccttaaa aagttttaca gaaaaatttt tttcatttaa tatagtgtac aactctttag
    26341 cttcattttc tgacttatta aaatttacta atacattgta accttctttt gcaaaagctt
    26401 tagacatagc tttaccaatc cctctagctc ctcctgtaat taaaactgtt ttcttcttca
    26461 taaatacttt tctccttata ttataaccaa ttcagtattt tatacaaaac aaactgccct
    26521 ttaaagaaaa tattttctat aaaaggacag ctcttatttt attaatattt attctgtttt
    26581 accaatgttt gcgccagttc ctgatgaagt tcctccatta tctcctgagt ttgagcctcc
    26641 tgaactatct ccattgtctc ctgagtttga acctcctgaa cttcctccat tgtctcctga
    26701 gtttgagcct cctgaacttc ctccattatc tcctgagttt gagcctcctg agtttccacc
    26761 actatttcct gagtttgaac ctcctgagtt acttccatta ttgcctgagt ttccaccact
    26821 atttcctgaa tttgagcctc ctgaatttcc accactgttt cctgagtttg aaccaggttc
    26881 tgttggtgta ttattctctg gtgttgttgg ttttttatct ggtactgttg gagtctgtgt
    26941 atttgatttt tctgaacctt tgcttacata tagatttacc tcatcacctt cctgagctct
    27001 tgatgagcca gcacctggac tctgacttaa aactgtacct tctttatata ttgagctgta
    27061 ttcatactta acagttccca cttttaagtt attttcttca ataagttgtt ttgcattact
    27121 caaagtaagt cccactacat taggaacaga tgcctgactt gaacctttac ttacgacaac
    27181 atttatagta tcaccctttt tgacatttgt acttccacct tcaggtgtct gtgatattat
    27241 acaattttca tcaacttcac tattatactc ttcacttttt acactcaggt ataatccttc
    27301 tttttcaaca gcactttgag cttcttctaa tgtcatattt acaagattag gaacagtcaa
    27361 agatttattg ccaaaccctc cagcaaataa aaacttatat gctaagaata cttgagcaca
    27421 caatatcagt atcaaaacag ccgcaattac ttttaatctt cttctagatt ttgggctttc
    27481 ctgttttttc ttctttttct tagttctctt acttggagta ctcttaggtc tctgattctt
    27541 tttagctctc attatctctt cctcttcttc atcttcatca tcatcttctt cataaaaatc
    27601 atcatagtaa tcttcatcat catccaaatc agctacttca acaggcttaa ccactttttc
    27661 aggagctggt tttgcaagtg ttggatttac aactttatta atttcttttt catcaatttt
    27721 cttagttgca aaatcatcat attcttttat aaaatctaaa tcaatatttt tttctatata
    27781 ctctatatct tctatcaatt cttcagcagt ttgatatcta tctgcactag atttttctgt
    27841 aagctttttt attgtagttc ttacactttg aggaatccta actttttctt ctgatgtaaa
    27901 gtctatatca tcattaatgt gttgaagtgc tatagaaatt ggactatctc ccctaaatgg
    27961 aacttttcct atcaacattt catataaaac tatacctaga gaatacaggt cagcattatt
    28021 agttacaaat ttacctttag cttgctctgg tgaaaaataa tgcactgaac ctattatact
    28081 accaatatta gtcattgttg aatttgaaac agctttggct ataccaaaat cagccacttt
    28141 tactactctt ccttcatttg atatgagaat attatgaggt tttatatctc tatgtataat
    28201 cccctttttg tgcgctgcac taagtgccat agctatttgt tttgttatat ctaatgcagt
    28261 atattcatct aatatacctt catcttgtat aatctctttt agattcttcc catctacaaa
    28321 ctccattaca atgtagtgaa cttttccatc ttcaccaaca tcataaacat ttactatatt
    28381 tggatgtgaa agacttgcta ctgcttctgc ctctctttta aactttgtta gaaattcatc
    28441 atcatctaca aattcaggtc taagtacttt aagtgcaaca gtcctgttta ataatctgtc
    28501 tttagcctca tatacaaatg ccattcctcc atcaccaatc ttcctgatga tttcatatcg
    28561 atttcctaaa attgtatctc ccacaatatc accgtcctaa ttatactttt atcactataa
    28621 ccgaaacatt atctttacca gaaacatcat tggccatact tatcaattct tcacttatat
    28681 tactagttct ctcatattca taatctaata ttaaatctct tatatcttca tcatcaataa
    28741 acccagttaa tccatctgtc gcaagaagta ttatatcact ttttttgatt tctttcttaa
    28801 aaatatctac aacaaccata tcatctgttc caattgctct agttattcta ttcctctgtg
    28861 gatgtcttct tgcctcttct tctgtaatga catgggccat cataagttct tcaaccacgg
    28921 aatggtctat agttatttta tcaaattttt catctgttaa caaataacat ctgctatctc
    28981 caacatttgc cacatataag acattattat acactatagc cgtaactaat gtagttccca
    29041 ttccttcaaa ttctatatct tccatagatt ttttgtgcac aattgagttt acattattat
    29101 aagcctgttt taatatatca tctatatagt ctatttttac attatcatgt tgtaataagt
    29161 tttcctttag aaaatcaatt atattttcta ctgctaattt actggcgact tcaccttttt
    29221 tatgtccacc cattccatca gctatggcaa atattcctat tggaccatgt tctgtatcta
    29281 taacttctcc ctcacaatag tcttcattgt tttttcttat ttttcctata tgggaggcac
    29341 aactataaac catacgactt cctccttaca aattacttgt attttcttct caattgccca
    29401 caagctccac taatatcaga acccatagac atcctaactg tggcaggtat attgttcttc
    29461 tccaaactat ccctaaattt ataaataaat gctttatctg gcttttcata ttctctttct
    29521 tcaactttat ttattggaat taaatttaca tgacatagca taccttttag gagcttagct
    29581 aatgcctttg cttctttttc tgagtcattt acccctttta taagagaata ttcaaatgta
    29641 acccttctat ttgtcttttt tatataatat ctacatgcat tcaatatttc ttcaatagaa
    29701 taagcatttg ctacaggcat aatttttctt cgttcttcat catatggtga atgaagtgat
    29761 aaagctaaat ttatagctat ttctaagtct gccaactcat acattttagg tactattcca
    29821 caagttgaaa gagttatatg cctataccct atattaagac catttttttc gttaattatt
    29881 tttaaaaatt gttttgtatt ttcaaagtta tcaagtggct caccactccc catcaataca
    29941 agatttgata ccctcttacc agtatcttct tgaattttaa taacttggtc taaaatttcc
    30001 catggctcta agtttctaat taatccatcc attgtagatg cacaaaaatt acatcccatc
    30061 ctacaaccta cttggttaga aacacagaca gtaactctac tatcataatc catcatcaca
    30121 gtttctatta tatttccatc atctaataaa aacaaatatt tttttgtatt atctacctta
    30181 gattctaact ttaattctat atctatatgc cctatacatg aaacctcttc taatttattt
    30241 ctcaaacttt ttggtatatt gttcatatca tcaaaagttt ttgcaccctt atatatccaa
    30301 gagaatattt gacttcctct aaagggcttt tcatctatag ttttcataaa ttctttaagt
    30361 tcatcttcag taaaattttt taatactatc tttttctttt ccattctctc actaccttat
    30421 tctctttaat tttgctatga aaaaaccatc tataccatga atattaggat atatctttaa
    30481 atatccttta tcttgattgt ctaagtctac atttactgta tcaattggaa caaattcaaa
    30541 gttgtgattt tcttcaacaa aagaagtaac tatatttata ttctccacat cttgaattgt
    30601 acatgtacta tatactaaag ttccaccaac tttgacatat ttagatgcat tttctaaaat
    30661 tttcttttgt atagaagtga tgtcttttaa ctcttcttct ttcttatact taatttctgg
    30721 tttacgtctt attataccaa aaccagagca aggaacatct gctaaaacat aatcaaattt
    30781 acttatacta ttttcatcaa tctcagaagc atcaaatctt tctacaaaca catttttaag
    30841 ccccaatcta tttacagtag agtttataag ctttagttta tgctcaaaaa tatctctagc
    30901 tactacttga ccagtattgt tcattaaagt agctaagtga gtagatttcc ctccaggagc
    30961 actacataca tccaaaacaa atgagccttc ttttggatta attactttcc ctactatcat
    31021 agaacttata tcttgaattg taaataaacc agccttaaat aattcatttt tttctatatt
    31081 tttcattttt tcgactttaa tagcttcttc taccatagga acttttaaac atacaatacc
    31141 catttcactt aatttttcaa taagttcttc tctacttatt ttaagtgtat tcgttcttat
    31201 atagatacta ggcttttcat tatttgcttc caacaaatct tcagcaaatt cttgtccaaa
    31261 tttatctatc cagtttttta taatccaaga gttataggaa tactttatag ataagtattt
    31321 tacactatct tcctcagtta tgtccattat agtctcttta gctcttattt catttctaag
    31381 aatagcattt atgaaaccag aagatttttt atcatatttc ttagataatt ttacagtttc
    31441 attaactgct gcataatctg atatactatc taaaaataaa atctgatatg ttcccattct
    31501 taaaaagatt ttaacataag ttgacatttt ttttaccttt atttttgaaa gtttattgat
    31561 tatataatct aaataatatt tattttctat tactccataa attaactctg ttgcaagtcc
    31621 tctatccata tcacttattt ctaaattttt aaaatgctta tttattgcaa tatttgaata
    31681 attgtcattt ttttctatat cacataatac tttaaatcca acttctcttg catccatata
    31741 aatttctccc ttttattaaa cataaaaaag ggttgtttct aaacaaccca ctttactttt
    31801 agtcatttct tctttgagct attagtaaca atctaagtaa ttgaagtatt gaaaccaatg
    31861 ctgctgcaac atatgttaaa gctgctgctg aaagtactct tctactttgt cttgactcac
    31921 tttcatctat aatacctaaa ttcccaagtt gaacgattgc tctacttgaa gcattaaatt
    31981 ctacaggcaa tgttattatt tggaataaca ctgaagccga aaacaatagt ataccaattt
    32041 ttaaaaatgg accagccata ataaatccta aaaatattaa aaaccaagat atacttgaag
    32101 caaaattcac tactggtact aaactacttc ttatttgaag aggtgcataa cctttagcat
    32161 gttgtatggc atgaccacat tcatgtgcag ctactgcaac agaagttata gatgttccat
    32221 aatatacatc ttctgacaac cttacagcct ttcttcttgg gtcataatgg tcacttagat
    32281 gccctctaac catttctatc tttacatcat acaaaccatt tgaatcaagt actcttcttg
    32341 ctgtttgctc tccagtatat cctcgacgtg tatttactct taaatactta tttgttgttg
    32401 aactcacttt aaattgtgca tatatagtaa gtaatatagc tggaattaat acaaccattg
    32461 ttgggtcaaa tccccaaaaa ccgccatata cagggtacat aaataacact ctcctaaaat
    32521 atatttttat tatacatcct cttaatattc acttaactta aaaacagttt aattacaaac
    32581 taatatattt tttcctgtta aaaagcctat agctttttca atatccatca tgtctacatt
    32641 agtatttaca caaggtccat taggtctttt gttaaataca cctaaaacag gaattttctt
    32701 aatatcttgt attccagatg tcaaatctct ttcacatgca acagctacaa cagctttagg
    32761 tttagtgtcc attataattt ttctagctag agttcctcct gtagctacaa atatttttac
    32821 attagttttt tcctttagct taattaattc tcctatgttg catcttccac attctttaca
    32881 attatctata tcattagtaa cttttaattt acaactattc tcttgaatac aatgaggtat
    32941 taaaattatt atatcctctg gattaaaatt atatttatta ctgtatatat attcattatt
    33001 taactttata tatattcttc taatatcact ttttgacata ccaaatgatg atgcaatgaa
    33061 agatataata ggaaataatc cactgacaat attaaaattt attttcatta tatttgagtt
    33121 aacatacttt cctttaatta ctctataagt aactactgtt gaacatagta ttataagtat
    33181 tagtgatatt attataatat ttatcatcaa ggagaatatt tgagttaaac ttattataaa
    33241 aaaattaaca actcctatca aaattcctaa tattaaaatc aaaatcccaa cacttgttaa
    33301 atacttcttt atatctgtca tacttttcac ctaacccaat actaaaccag tttctatagt
    33361 attccctttt atatattcac caaccaacat tctcttttta ttcggcatct gaatttcttc
    33421 aattaaaagt acattatcta tagtacttac ttttatccca tctttgctta catcaattat
    33481 tgtacctaca tcttttgtgc ttttttcatc taacacttta gttttccaaa ctttcattat
    33541 gacatcatta taggtagtat aagcacttgg ccatggattt actcctctaa ctaaattgtg
    33601 tatttctctg gcactttttg aaaaatctat gttacctaat gatttattca ttattggcgc
    33661 ataggaaaat tcttcatgat tttgtacttc tcttggagca tttccttctt caattaatct
    33721 taatgtttct tttaaagttt ctgctcctat attcatcatt ttatcatgaa gttctcctgc
    33781 tgttatattt tcatcaagat ttacttctgt ctttagtatc atatctccag tatctaatcc
    33841 ttcatccata tacatagttg taacaccagt cttttcttca ccatttatta ttacccaatt
    33901 tataggtgcc gcacctctat attttggaag taaagaaaca tgaacattta tacatccaag
    33961 tttaggaatc tctaatattt cttttggaag tatctgtcca aaagctacaa ctactattac
    34021 atctggattt aaagatttaa ttttatctat aaattcttta tctctagcct ttactggttg
    34081 atatacaggt atattatttt caattgccag ttcttttact ggactcatac ctagtttttt
    34141 acctcttcct tttggtttat ctggttgagt tacaacaccc aatatttcat acttctcatc
    34201 tattattttt tgtaaacatg gaactgctat atcaggagtt cccataaata ctattttcat
    34261 caaatcaact cctactactt ttctattttg tcaacaaata aaattccatc taagtggtct
    34321 atctcatgac aaaatgctct agctaaaagt tcttctccct ctaactctat tgtttcacca
    34381 tttctattta aagctctgac ctttacataa tttggtcttc taacatttcc cgcttctcca
    34441 acaacactta aacatccttc ctcatctatt tgctccccag atgtttctat tatttcagga
    34501 tttataagtt ctataagctc ttctccaata tctattacta ctactctttt taatattcca
    34561 acttgaggtg cagccagtcc aacaccatct gcatcataca tagtttctgc catatcatct
    34621 aataattgta ttatcttttc atcaattttt tcaacctttt ttgatttttt tcttaatact
    34681 ggttctccta tttgaactat ttgtcttaaa gccattataa ttcctcctaa atttataata
    34741 cactgtttgg attaatatct atagatacat tgatattctt atcaaatatc aaatctcgtt
    34801 ttgttataca tatatatttt attataccct ttaagagatt aatttcaata ttttcatctt
    34861 taaagagtat ttgccatcta taattttgat ttatttttga tattgaacat ggatttggac
    34921 ctaatataaa tcctaaatca tttatacccc ttttttctaa taaataaatc aatgatgcat
    34981 gcatattttt tatatttttt atcactaatc tttcatcttc accactaaca actacactta
    35041 acatattatt aaaaggagaa tatccaaatg cttttcttat ttttatctca tcttcataaa
    35101 aaccctcata atcatattca atagcatgct taatagcata gtgttcagtg tcataagtct
    35161 gaagtactac ttttccctct ttatcagctc tccctgctct tccagagact tgagttatca
    35221 attgaaatgt agtttcaaaa cttttaaagt ctggaaaatt taatatcatg tctgcagaca
    35281 aaatacctac taaagttaca ttctcaaaat ccagcccttt acttaacatc tgtgttccaa
    35341 taagtacatc tgcttcttta tctttaaatt tatttagtat ctcatctaaa gcaccttttt
    35401 ttgaagttgt atctttatcc attctcaaag tttttatatc tggaaaaata tattttaatt
    35461 cctcttcaat tttttgagtt ccaactccaa atggcttaac ataagtactt ttacattcag
    35521 gacactcttt tggaatttct ttctcatatc cacaatagtg gcatcttcca gtattgcttt
    35581 tcttatgata agttaaagat atatcacaat tttcacattg aaacacatat ccacactttc
    35641 tacaagatac aaaatttgca taacctcttc tgtttaaaaa tagtattact tgattatttt
    35701 cttcaatcgc ataacgtatt tctttttgta atttcaaact aaatatactt ctatttcctt
    35761 tatctaactc atctttcatg tctacaactt caatgtttgg aagaggctta tcatttgctc
    35821 tactttttat atttataagt ttgtattctc cagattttgc cctataatac tcttcaattg
    35881 agggcgttgc tgaacctaaa ataagagtta tattattttt taatgccata aatctagcaa
    35941 cttctatagc attaaatttt ggattcttct cagacttata tgatgactca tgacattcat
    36001 caattattat taagcctaag gaattaaaag gtgcaaataa agctgaccta gctccaatta
    36061 acactcttac tttacctgct ttgacagctt tgtaaacgtc atgtttttct ccttcagata
    36121 gtttactgtg gaacactcca actaaatctc caaacctact ctttagccta tctattgttt
    36181 gaggagttaa tgctatctca ggtactaaga atatactgtc taagccttga tttagagcaa
    36241 attctattat ttccatgtaa acttcagttt ttccacttcc agttactcca tgaattaagt
    36301 atggtttttt atcatctaca aacatattcg actttatctc atcaactgct tcttgttgct
    36361 cattgtttaa ttttatactt tttagtacgg atttgtaaat actttttggc tctctataat
    36421 aatccttaaa ttctagggtt attagctttt tcttacttag agaatttata ctttgttttg
    36481 aagcatttaa taaatccaat aaatcattta tctctacatt ttcattattt ttaagaaaac
    36541 ttaatatctc tttttgttta cttcccacat ttattttatt ttgctctata taatcgtcaa
    36601 tcttatcact ttctaaactc aaagatatat aacatacttt cttttcattt ttgtgatttt
    36661 tatattccca acataatttt ataattccat ttttattcat tgtgtacaaa gaactattta
    36721 agtttggtat atattttaac ttatcaacct taattttacc tttactatca atcactttct
    36781 ctactatttc tctattttta tcacttaaag ttgatatttt ttccttcaat tcaatatcat
    36841 ttaatccact taaactttca cctaatagga ctactttata attatttaat ttgtatccct
    36901 ttggatatat caaatttata cattctatat aagtacacaa atatctattt ttcatccaat
    36961 aaaccaactc taaatcttct tttctaaata tcggattttc atctaatata tcaataattt
    37021 cttttatttt tattttttca tctaagctat ctgtaaattg aaatacaaag gcttctgttg
    37081 gtttattacc ttttccaaat ggtactaata ttctgtgccc aatttttatt acatcagata
    37141 aaaatacagg aatttgatat gtaaataaat tatctgtata tatagtatta cttctaacta
    37201 ttacctttgc atattttttc attataaaac ctctacttaa atttaatata ttgttcatat
    37261 tttaatatac tttacaagat attaaaatct cagaatttat aagcaatttc aagttattaa
    37321 tattaacttt attttaataa ttaactatta attatatttt atactttatg acaaaataaa
    37381 tgctgaaaac tacaatttaa ctgacatttg cgagttttta ctcgctaaaa ttaaattgca
    37441 gctttcagcc actttagctg tgataaaata cacaaatatc atatttaaaa aaggtcttat
    37501 ttctcaagca acgctttaac tttatctaaa ataacattgg ctacttcttc ttttttcatc
    37561 ttaggatact cagtaatatt tccctctaca tctattattt ttacaatatt agtatcagct
    37621 ctaaaaccag caccttcttt agttaaatca tttgccacaa taaaatctaa atttttcttt
    37681 tttatttttc ctttggcatg ttctataagg tcattagttt cagctgcaaa tccaattagt
    37741 atcttatctt cttttatttt tcctatttca taagcaatat cataatttct acttagttct
    37801 attgataaat catcattctt ctttttaatt tttttgtcag aataagtttt tggtttataa
    37861 tctgcaactg ctgcactttg aattactatt ttattttcac ttaaatttga tactactgct
    37921 tcatacaaat cttgtgctga ctctatttga acaaattttt taagattttg tggaatagaa
    37981 agatttgtag gacctgatat taatgttaca tcagcacctc tagctatagc ttctcttgct
    38041 atagaatatc ccattttacc agaagaccta ttagttaaat atcttactgg gtctatactc
    38101 tctacagttg gaccagctgt aactatcata ctttgacctt ttaaatcttg ctctttagta
    38161 agattagtca aaacttcctc tactattata tctggattag ctagtttacc tgttccaata
    38221 tctccacatg caagccttcc actttccggt tcaataaatt tatatccaaa gctctttaaa
    38281 gtttgtatat ttttttgaac aattggattt tcatacatat tagtattcat agctggtgct
    38341 ataagaacct gtgcttttgt tgccataaca gtagttgtca acatatcgtc agctatacca
    38401 tttgcaatct tgcctataac atttgcactt gctggcacta ttaagaataa atctgctttt
    38461 tttgctaatg atatatgttc aacttcccaa gtttttggtt cttcaaacat atcttctact
    38521 acataatttt gactcagcga ttgaaatgta agtggtttaa caaattctgt tgctgatttt
    38581 gtcattataa catggatatt tgcatttagt ttttttaact tacttacaac atcacaagcc
    38641 ttatatgcag ctataccgcc acttatgcca attacaacag ttttatcttt tagcatgacc
    38701 ttactcctct tctgaaattt gttggtgttg ctcagcatga tgtctagctt cttctatctc
    38761 tatttcctct tctgtcaata atctatatgt tatttttcca cttgcaactt ctttagttgc
    38821 tacacataca ggcttttcct tagttttatt tgaaacatat ggttcttctc catcaattaa
    38881 ttttcttgct ctctttgaaa cagtccccac taaatagtat ctgttgtcta ttttttctag
    38941 tacctcattg atagatggtt ttaacataat tataattcct ccttaaattt ctctattata
    39001 atatttttat atctgctaac tttattcttt tcagatgata ttataccttc tatttcttta
    39061 gcagatgttt ttacatcttc attaaatata aaataatcat aatccttaat cattttaatt
    39121 tcttcatatg cacagctaaa tctcttctct atttcagctt ctgtttctgt acctcttcca
    39181 acaattctat tttttaattc ttcaagtgat ggtggtagta caaatataaa tactccctct
    39241 gggcaaactt cttttatttg ttttgctcct tgcatttcaa tctccagtaa tacatcttgt
    39301 cctttttcta aacattccat tattgccgct tttggagttc cataaaaatt atcataaatt
    39361 tgagcatact ccaaaaactc acctttttct atcatctctt caaacttttc cttacttatg
    39421 aagaaataat ttactccatc aacttctcca gttctgggtt ttcttgtagt agctgataca
    39481 gaaagtttta ttgtatcatt ttctttaagt agttctttgc aaatagtacc ttttcctgca
    39541 cctgatggtc ctgatacaac tagcaataat ccttttttca caaacattta agcattcccc
    39601 ttctaatatt gtattcttac tctatatttt gtatttgttc tcttattttt tccaattcgc
    39661 tttttacttc tactactaaa ttagttatat ttatatcaga tgacttcgaa cctatagtgt
    39721 tagtttctct attcatctct tgtattaaga aatctatttt tctacctata gagtcgtctt
    39781 taaatatagt atttttaagt tgccctatat gacttttaaa tctaactatt tcttctgtta
    39841 tactgctttt atctgcatat attgcaactt cttgtgctaa tctattctca tctattatac
    39901 ttgggtcatc cagtaattca cttattctca aattcaattt ttctctataa tcttctacaa
    39961 cactacttga atatttttca atctcttcta tatgattttt taataaatca catctcatgg
    40021 caatatcttc agctaatttt ttaccttctt cacttctcat ttctcttaat ttgattaatg
    40081 catcttcaac tgcttgattc aacattgacc acaataaatc ttcatcttct tccttttctt
    40141 ctattttcac aatatcagga aactttgcaa cattcataac gctaatatca tctataatat
    40201 caaatttatt ttttatttct tttagtatgt ctatatactg agatgctaat ccctcatcaa
    40261 aatttaagtt tacatcttct ttgcctaata agtcaaactt tatgtataaa tctactcttc
    40321 ctctttttac ataatttttt actaaatttc taactttatc ctctaaaaat gaaatttttc
    40381 ttggaagacg tatgtttata tctgaatact tatgatttat cgttttacac tctactaaaa
    40441 agtaataatt atcatccttg tattctcctc ttccaaaacc agtcatactt atagccatta
    40501 attaaacctc caaaatacct tcacatattt ttactgctgg acctgtcata taagagaaat
    40561 ctcctacatc tattttaact gttccacctt gagacgttac atttacacta ctttctacca
    40621 tattaagtaa attgcacact attgctgatg cagtcatacc agtaccacaa cctaaagtat
    40681 atccacaacc tctttcccaa gtataaacat gtatattata cttatcttct acctttacaa
    40741 aatttacatt cgttttttca ggaaatattt tattattttc aatctctttt ccatatttac
    40801 aaacatcatc tacatctaat tcatctacta taactactgt atgaggaacc cccatcaaca
    40861 tagaagtaac tttaagctcc ctatctaaaa cctttatact ttcttgcaca aaacgttctt
    40921 tatttgtaag tacaggaacg tccttagcta taaaacttcc ttttcccata ttgactctta
    40981 tagagtttat ttctctatta gtaagattta cttttatatc ttttatacca tctaatgtat
    41041 ctactgtaaa actttctttt ttaactatac aattatcata aacaaattta caaaaacatc
    41101 taaggccatt tccacacata gctgctcttg aaccatcaga attataatat accatttcta
    41161 catctgcaac ttttgaatct ttcacaacta acaatccatc cgctcctaca gaaaatcttc
    41221 tatggcatac tttttttgct aaagcagtat aatcagatgg atttatctgg tcgaatcttc
    41281 catctattgc tataaaatca tttcctattc catgtagttt ccaaaatttc ataagtatcg
    41341 ctccttcgta aattaacgct taaactatta taacataaaa aaattcccat aaacttataa
    41401 tttatgggaa aagttttgta atgacaacta taatttgagg atgtgaggga gagttgccat
    41461 tacaattagg gtaattatat tatgttttta agctagttct ttctatgttt atatattaat
    41521 atttctatat gaattttatg tatgttttat ttaaactgtc tatgaatttt ttaattaaac
    41581 atctggtaac tagctataat ccttctagta gatatctatt aacatacacc tattaattct
    41641 ttaagtgttt ttaaaacata gtctaaatct tccttagtaa tatctacatg agttacaaat
    41701 ctatattcac cattttccat tttattaatt tttatatttc tttcaaaaaa ttcttttatt
    41761 aaaacatcct cttttataat atcttcactc atcttaaaaa ataccatact tatatctgga
    41821 ttaacattgt ttacttcaat gccatcaatt ttatttaatt cacaagctaa atattttgca
    41881 ttttcatggt cttcattcaa tcttaaagtc attttttcaa tggcaattat accagctgct
    41941 gcaactatac ctacttgtct cattccccca cccataactt tttgctttct tctagctttt
    42001 gctataaatt ctttatttcc agcaagtata gaacccattg gtgcagctaa accttttgac
    42061 acacagaaca taacactatc acaacacttt gctatttctt tagcttctac acccaaagtt
    42121 aatgctgcgt taaataatct tgctccatct aaatgtactg gtaagttatg tttctcagct
    42181 atttttttaa tttctcttaa attatcaaga ctcacaactg ttccacctga atatgcattt
    42241 tctacacata taagccctgt ctgtggttca tgtatgtcat ctcttctaat tgccttttca
    42301 acaagttcag gatttagagc tccactttcg tcttcatcta tagttctaag ctgaactcca
    42361 gctattacag caggtgcccc aacctcatga gtcacaatgt gataaccttt accaataatt
    42421 atttcttgcc ctcttaggca atgagtaaat agagctaatt gattcccaaa agttccactt
    42481 ggaaggaaaa tagcatcttc ttttccaact ttagctgctg ctaattcttc aagtttattt
    42541 acagtagggt catctctaaa gattgaatct ccaacaggag cctttgccat agcttctctc
    42601 atttcgtcag taggcatagt aacagtatca cttcttaaat cgataaatct cattttttca
    42661 accttctttc atatttatat actatagaac cttaaaattg attttttctg taaagttcat
    42721 atactttcat agcttatact ctacacaata attatactat atttacttta tatttaatct
    42781 actttaaatt attaatttta aaaataaagt ttcctctcta ataaatataa ataattatac
    42841 aatttaaata ttaatctcta ttgtttaaat tccccctagt cacaaagcgt atattatgtg
    42901 tataattaat ttactgactc attttggtca aagaaagggg tgctataaat ggcattagat
    42961 ggattagtta tacattcaat agtcgatgaa ttatcatcaa aacttacagg tggaaaaata
    43021 gataagatac atcaacctga agatgatgag gtaattttta atataagaaa taataaagaa
    43081 aattttagat tggttttaag tgcaagtgcc tcaaatccta gagtttatct tacaagtaat
    43141 tatcaaaaag aaaaccctct aaaagcgcct atgttttgta tgttacttag aaaatacata
    43201 caaggtggaa atatagtaga aatttctcaa ataggttttg aaagaataat aaaaataagt
    43261 gttgaatctt tagatgaatt aaaagaaaag acagttaaaa atattatgat tgaaattatg
    43321 ggaagacata gcaacataat aataactcat ggtgaagaaa ataaaattat agattctata
    43381 aaaagagtcc cttttagcat aagtagagtt cgtcaagttt tacctggtca tgattattca
    43441 ttgccaccag aacaaaacaa actcaaccct cttgatgata tatctaagga tttgtttatt
    43501 aaaaacctag aggaattgga aggacctatc tttaagtcta tatattctaa atttctaggt
    43561 ataagcccta ttatagctaa agaaatttgc tacagagcag gtgtaaatca aaatgctatc
    43621 ataaaggata tatctgatga acaatttgat gctttacaca aagtattttg taatttattc
    43681 aatgatataa attctaacaa atactctcct tgcattatta tagataaaaa ggtggataag
    43741 gtagttgatt tcagttgtat aaaccttaca ttatttagcg atttatcata tataaataag
    43801 gatagtatgt ctcgtattct ggaagatttc tatagaacta aggatattaa agatagaatt
    43861 aatcaacgtt catctgattt aaagaagagt atatctgtta agcttgatag actttataat
    43921 aaacttaaaa aacaagaaga agaattatca gaatccgaaa atgcagacat ttataagata
    43981 aaaggagaat tgattacttc atatatttat atggtagaaa aaggtatgga aagtattgaa
    44041 gttgctaact tctatgatga aaattgtaat gatgtaacaa tagaattaaa taaaaacttg
    44101 acaccatctg aaaatgctca aaaatacttt aaaaagtata acaaaatgaa acatgctaaa
    44161 gtcgagatat ctcatcaaat ttccttaaat aaggaagaaa tagattactt agaaaacata
    44221 attttaagta ttgaaaactg tgaaaattta gctgaattac aagatataaa agaagaactt
    44281 gctaaagttg gatacatcaa gactcaaaag aaaaacagta aaaaggatac tatcccatct
    44341 acaaaacctc atgaatttgt gtcttctgat ggatttaaaa tattggttgg taaaaacaat
    44401 aagcaaaatg actatcttac actaagactt gctgataatg atgacttatg gatgcataca
    44461 aaaaatattc ctggttctca tgtaataata aagtgtgctg gtaaggaagt ccctgataat
    44521 actgtatttg aaggagctat gctagcagca ttctttagta agtcaaaact ttcttctcag
    44581 gtgcctgtag actatactaa gagaaaaaat gtgaaaaaac ctagtggttc taaaccaggt
    44641 atggttattt atgaaactaa cagtactatt tatgttactc ctgaagaaga aacagtagcc
    44701 aagcttaagg ttaaatctga ataaattctg cactaaatac aaaataaatg ttagacaact
    44761 acacattatc attctaaata aaaatagtgg ccttcttata aagtacaata ataaggccac
    44821 tttctaatta gcttactttt aattttctaa caaaatactt ttctgtttta ataactatac
    44881 ttatattccc aacaaatatt ttcagtcttc ttatatagat gtaattaaaa agttaacact
    44941 aaaagctatt ttttaattta ttgatttgtt ttagtaattc attatattct gattcataca
    45001 attctttttt tagattatct ttttctatag ataacataga tataacagtt gtaagtctat
    45061 tttctaatac tagaagattt tcttttttga tttggttttc tctactagga gtttttttat
    45121 ttctgctaat tgtatattcg tcataattac aatcaaactc ccttatttta gcatctttta
    45181 tctctataat atagttacaa atatgtgata caaatactct atcatgagac actataagca
    45241 tagttttatc agtatttatc agtgcctttt ccagtgcttc catagatttt atatctaagt
    45301 aatttgttgg ttcatcaaat actaaaaaat tattatcttc caatattatt ttacatagtg
    45361 ctatttttac cttttctcca ccactaagta cttttacttt tttgtagaca tcatcacctt
    45421 taaacccaaa taggcttaag tttatcctta taaaagattc atcaaatgaa ctattaactt
    45481 tagtattgta tagaacactc ttttcctcat ctaataaact ttgattttgg tcaaaataac
    45541 ctacttttac cttgttattt atttttatat tgtcattttt atcagccaat atttctttta
    45601 tcagagtact ttttccacac ccattatcac ctaacaatgc tatcttttta cctcttttta
    45661 tcttaaagga aacattatct aacaggagct tattttctaa ctttagagtc atatctttta
    45721 cctctactag atttttgcta attatctcca taccatcttg catcttaatg ttcatttctt
    45781 tagaaacttt aggtttattc tttacctcaa gtttatcaat tctgcttttt atagccttca
    45841 catttgagtc caactttttc ttattagtct gaccacccat tttgtgcaac ctagcttctg
    45901 aattacccat tctttttggt gtttttctta tgccatcact taaagctttt ttatataaaa
    45961 gagctttttc aagccttttt ttctctttaa catattcttg atactcaaaa tcagctcttt
    46021 ttacttcttc atctttttgc attaaataat cagtgtaatt gcctttgtaa gcttttagtt
    46081 ttccatcttc tagttctaat atagttgtac ataactcatc cagaaaacgt ctatcatgag
    46141 atattaataa taatgctccc tcatgccttt taaacatatc ttccaaaacc ccaatgcttt
    46201 ttttatctaa gtttgaagtt ggctcatcag ctattatgat atttttctta ttactcagcg
    46261 catctgctat ttttaactta accttttccc ctcctgataa gtgttcttca aatttatctg
    46321 gagcatttaa aagactcttc tccttactat gactacatgt ttcaatatta ttttcactct
    46381 gacttatata agaatagctt tctgtaaggt aagtatatcc ttcatcaatt tctatttctc
    46441 ccaatattgc ttttaataat gttgtttttc cttgaccatt tgaaccaact agacctattt
    46501 tgtcattttc taatatttca agtttatcta tatccaaaat taatttatct gcataatatt
    46561 tctttaaatt ctctactttt actaacaaca taaaaaatcc ctccttaaca cacttaaata
    46621 taaggagaga ttctataaat aggcataaca aataaacgta tagactataa tctactctcc
    46681 ttaatttaag cattgcaaat aaagccacca aaataggctt ttcaaaaatt acaatacttt
    46741 aaattataaa aaatagatta tattctcatt gtcctagtta ccttgccctt tctttcattt
    46801 atttttaatc attatatcaa cattaattac aaatgtctat agaaaattaa ctaattttag
    46861 ttattcaata tacaacttat tctttaaatt tattcttctt caactttaaa gtcctgatta
    46921 tttaaaattc tgtttaatac aattccaaca attgcagcta aactaagacc agttatcttt
    46981 actgtacttg ttatagggat tccaacagaa atacctttat tagataaata tgttgttcca
    47041 agacctatta ataatataac tgctatgatt aatatattta ttttactttc tacacaagaa
    47101 ctgtccctta tagtttttaa tcctacataa gttatcatcg aaaatagcat tatactaatt
    47161 ccacccataa ctgaacctgg tatactttga agaaatccac caaacttgcc tacacatgca
    47221 agcaatatag caaatattgc tgtacgtcta agtattgaag ggtcatagtt tttagttata
    47281 gcaagtactg ctgtattttc tccataagtt gtattggctg gtcctcctaa acaccctgca
    47341 actatagtcg caaatccatc cccaagtaat gttctattta atccgggatt ttctataaag
    47401 tttttaccta ctacagcacc attagtagtc atatctccta tatgttccat aaatacagct
    47461 aatacaactg gagatataat cactattgct cctaaactga acttaggaac tgtaaagtta
    47521 ggtattgcaa ataaacttgc ttctgtaata gtagttatat ctactaatct taatatcaaa
    47581 cagattatat acccagaaaa aactgctatt aatattccta attgttttat aaatcctcta
    47641 ccaaacttat tggttaaaat tgctattgct aaagttataa atgctatcac aaaattggct
    47701 gaagccatac taaaagctgt tggcaataaa tttaatccta taactactat catagctcct
    47761 gtaacttgtg caggaaaata taatttaatt ttatttacac caactacttt tactataatc
    47821 gacattataa tataaattaa tcctgctact attataccac cttgagcata tgctaaatct
    47881 ccaccatatg cctctttagc tgctagtata actggtataa acgcaaaact tgaacctaaa
    47941 aaggcaggta cttttccttc tgtacaaaaa tgaaatatca atgtaccaac accagcacag
    48001 aaaattgcaa ctgacggatt aaaacctgtc aaaatgggaa ctaatactgt cgctccaaac
    48061 atggctaata gatgttgtaa agacattatc gtttttttca taaaaacctc caaaattatt
    48121 atatataaat aaatcctctg tttaattaat atcttttaat taattatcat tccctagatt
    48181 ctatttttta acctctatat acttattata taatttatca ttattttaca ttttacgaca
    48241 tcaaaaactc aaataaagga gaataaaaac tacattaaga ctcacatcca taaaattata
    48301 atatttattt tgtgcaatct atgtaagctt tatcctcctc cctgactatt caatgctaag
    48361 cttttatata atacttaaaa ataattattc tttgattgta actgaatctt ctccatcaat
    48421 ttctaataaa ctgacagata taatttcatg tctagaagta ggtacatttt ttcctacata
    48481 atctgctctt ataggcaact ctctatgccc tctgtccact agcactgcta attgtattga
    48541 tttaggtctt cctatatcta taatagcatc tagtgaagct ctcacagttc ttccagtgta
    48601 taaaacatca tcaactaaaa ctactgtctt atcatttaca ttaaaatcta aataagttcc
    48661 tttaactaca ggttcaacat gaattttttc caaatcatct ctatacaaag ttatatcaat
    48721 atctcctgta tctacttttg ttccttctat ttgttctatt ttcttagaaa ttctatttgc
    48781 aattggcaca cctctagtct ttattccaac taaaactaga ttttctacac ctttatttct
    48841 ttcaattatt tcatgactta ttctagtaat tgctcttgct attgcctttt catccattaa
    48901 ttgagctttt tctaccatat cataattatt gtcaaagata taatatatct atttgacaaa
    48961 tctactcctt tcttttaatt ttttataaat ttatttttat ttaaaatttc aatttaaaca
    49021 acaaaaaaac ttctcatcac aagacaagaa gctcttatat aaaaaatata cagtgcaatt
    49081 tagcaattgt cttacgatat ctctgtatcg tttaaagata attttttaat ctatcaaatc
    49141 aaattatata tttatatttc aaatttttca agctttttta aacaaaatac tttaatataa
    49201 gatattttat ttaaatttca ctaaatttat ttacttatat aaaaacaaaa aatgatttat
    49261 aagtattata caaatagtta ttttatcttt ttaataactt ccttaaaata ctcaggtaat
    49321 tctgaattaa attcgatata ttccttagta gtaggatgta taaatcccaa cttcttagca
    49381 tgcaaagttt gtccttttaa tttaaattta gtttcttttg gaccatatac ataatcacct
    49441 aaaagtgggt gatttataga caaagcatga actcttattt gatgagttct accagtttca
    49501 agcctagctc tcatatgtgt aaacttatca aatctttcta caacttcaaa gtgagtgatt
    49561 gcattttttc catcttttac tacagccatt tttaatctat ccttaggatt tctccctata
    49621 ggtttatcaa cagttatttt atcttcttta accacaccat agcatataaa ttcatactcc
    49681 ctagttatag tatgttcctt taactgttct gctagaaaat tatgtgcata attgttctta
    49741 gctatcataa gaagaccaga agtatctttg tctattctat gaactatacc aggtctaata
    49801 acgccattta ttgatgacaa cttatcttta caatgatata aaatcccgtt tactaacgta
    49861 ttttcatagt ttccaggagc aggatggaca accatatcct gaggtttatt tattattaag
    49921 acatcatcat cttcatatac aatatctatt ggaatatctt gaggtaaaac ttctaatact
    49981 ttaggttctg gtatctctat aacaatatta tcttcctctt taaccagata tctagctttt
    50041 tctactttat tattaacctt tacttttcca tcttttataa ttttttgtat ataacttctt
    50101 gacatatcac ctaattgttc tgctagataa atatcaagtc taacttcttc ttcctcttca
    50161 agtactaaaa actcttttac ttcatccatt atatcaccta cttttacttt caaaaaataa
    50221 aacatatata cataaaaaca cagttcctac aactacaaat acatcagcta tattgaatac
    50281 atattcccat ataattctaa agtcgaagta atctactaca aaacctaatc gtactctatc
    50341 aattagattt cccaatgcac cagatataat taatataatt cccaaccttc caaatatatg
    50401 tactttcctt gtattaagat agtatagtcc aaatactgtt gcaagtaatg caacaattat
    50461 aaatatccat tgattatttt gtaataatcc aaatgctgca cctctatttt cgacataagt
    50521 taaatgaaat acattattta ttattggtat tgttgataca tccaccaaat tattcaatac
    50581 ccatatttta gacagttggt ctaaacctat gagtagaatt attattaata tatatagcaa
    50641 tgatttttcc ccctataaat tatttaaaaa ccaattttat ttgaagcaca ctattattat
    50701 tatacaaaaa aaatgctcta aagagcaact ttattaaaat tgtattttct taataaagct
    50761 agaacaaaat ttaaaatagt actacttttt ttatattgta gatttctaca tatttaaaat
    50821 catatcatta tgtataaaaa atttaaaaat accatactaa tcaatatttt ttgtgtattt
    50881 tatagattaa agattaatga tgtctgtaat ttaaacttac aatcaccact aatcttcaaa
    50941 caaatatttt tacttttgca cttgcttatt tttatctaaa tgttgtataa gttcagatac
    51001 tgttacgaat ttatatcctc tctcttttaa tttaggaatt actacttcta aagcttgtat
    51061 agtttgtgat ttatcatttc ttttagtgtt ataatcatgt aaaagtatta tattaccatt
    51121 ttggaccttt gtaaggatag tatttataat tgcatctact ccagggttag accaatctct
    51181 agggtctaag tttgaccaaa gaattatatt catgccttta gaaactataa tatcacagac
    51241 acttttactc atggctctat atggaggtct aaatatcttt ggttctactc ctattacact
    51301 ttttataata ttttgcgtat ctgttatttc tttttcaaca ctactataac tattttttgc
    51361 aacatttata tgtgtaaatg tatgattccc tatttcatgc ccctcatcat attgtctttt
    51421 taataattct ttgttatatt ctactttttc tccaactaca aaaaaagttg cttttacatc
    51481 atttttcttt aatatatcaa gtacttgtgg tgtaaaatcc tcatctggac catcatcaaa
    51541 agttaatgct aaaatttttt catcctcatt tccttttttt attattacat cttcataatc
    51601 gtcttttata ttgtcattta aactatatgc ttcttttgaa ctatcttgat tatgtgtatt
    51661 atgattatat gtatatacac ctactataga taataaacat atacatatac cccatattat
    51721 tttcttcatg tcattacctc ttttctaatt cattctagca atatatttta taatgtcagt
    51781 tttttaatct ctcaatattc catttttatt taaatcagtt aaatttgtta ggtcttctga
    51841 ataaaagtta gaatcttcta catcagggtt ttgcattgca tcacctaata aattattttc
    51901 tttctttgca caatcattac ataaacttgt atctggcaat atatccaatc tttctaaatc
    51961 tatttgatta tgacataaat cacaaatccc atatgttcca ttctctattt tagataatgc
    52021 taagtctatt tgatacaatc ttccctcttc atgatttatt agactgtttt gcatattttg
    52081 catatataaa tctgttccca tgtctcctat atgattatca taactagata attctcctga
    52141 tgaatacttt tcacttgtat gtttagttgt atctccaaat aaagtattat ctttcatatc
    52201 ctctactaaa ttagttaaat tttctctttc tttcaataat ttatctttat attttttagt
    52261 atccattttt aacacctcta attttaatat ttacatcata aaaatagtat gtggaaaagt
    52321 aaattaaaca tacaataaaa ataagatttg attcgaaaaa tgga
//
LOCUS       DAEPID010000023        51973 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.023, whole genome shotgun sequence.
ACCESSION   DAEPID010000023 DAEPID010000000
VERSION     DAEPID010000023.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 51973)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 51973)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..51973
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.023"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     misc_binding    267..498
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00230"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="T-box leader; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /bound_moiety="tRNA"
                     /db_xref="RFAM:RF00230"
     gene            606..2087
                     /locus_tag="KR257_001462"
     CDS             606..2087
                     /locus_tag="KR257_001462"
                     /EC_number="4.2.3.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897260.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="threonine synthase"
                     /protein_id="HBH0030171.1"
                     /translation="MYYSSTRGTEEKVTASQAIIKGISNDGGLYVPSEFPNVKNELIN
                     LVNLTYSQIAFFVLSKFLCDFTEDEIKNCIENAYDEKFDCSSIAPLNKVNDTYFLELY
                     HGPTLAFKDMALTIMPHLLKTSIKKDNLEKDVVILTATSGDTGKAALEGFKDIDKIKI
                     IVFFPEDGVSPVQKLQMKTQTGKNTYVVGIKGNFDDAQSGVKKIFSDKEFNQKLLDNN
                     YILSSANSINIGRLLPQVAYYFYSYMKLVSNSDINLNDKINFVVPTGNFGNILAGYYA
                     KQMGLPINKLICASNDNNVLYDFFKTGVYDKNRTLKLTTSPSMDILISSNLERLLFEI
                     SNRNTDIVNKLLSDLSDKGVYKISDDMEKNLASFYGEYSNEEEVKSTINNVFKNYNYL
                     IDTHTAVAYNCYEKYKKETSDNTKTVIVSTASPFKFSEDVLKSIDCDFKDLDDFAIID
                     RLSSISKIDIPKPIKNLKNAEILHKDIYEKDELKLAIKKFLKV"
     gene            2097..2990
                     /locus_tag="KR257_001463"
     CDS             2097..2990
                     /locus_tag="KR257_001463"
                     /EC_number="2.7.1.39"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897262.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="homoserine kinase"
                     /protein_id="HBH0030172.1"
                     /translation="MLEIIVPATSANIGPGFDCLGIALNIYNKFYVEEIESGLEIEGC
                     EDAYKNENNLVYTSMKYFFDRVKPEKIPAGIKIKIQSEVPICRGLGSSASCIVAGVIA
                     ANALSGANLDKNQLLNIASEIEGHPDNVAPAILGNMIVSVTDNENIHYDIIKIPEELK
                     FCAMIPNFKLSTEKARGVLPKEIPYSDGVFNVSRVALLISALLNKNFDLLKVACQDKL
                     HQDYRGTLIENYNDIVEKSEQLNSIGVFLSGAGPTIMSLIKENDDSFVDNMKNYLQKL
                     KSDWEIKELCCDSNGAVLNII"
     gene            3114..4175
                     /locus_tag="KR257_001464"
     CDS             3114..4175
                     /locus_tag="KR257_001464"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015617764.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nitronate monooxygenase"
                     /protein_id="HBH0030173.1"
                     /translation="MIIKELIIRDLVAKVPIIQGGMGVGISRSSLAGAVAKLGGVGVI
                     SGVQIGYDEEDFETNTINANLRAIKKHISKAKEISNGGIIGINFMVAMKEYETYVKEA
                     VKAGVDLIISGAGLPNKLPSLVKGSNVKIAPIVSTAKAANVILKMWDRKEKTTADLIV
                     VEGPKAGGHLGYSNEELDNIDSIDYDKEFVEILKVANTYGEKFGRNIPVVAAGGITSS
                     SDVKKYIDMGASGVQVGTRFVATYECDAHENFKMAYINASEEDVHIVKSPVGLPGRAI
                     RNKFIEEVKINRPEIKKCYNCLIPCNPKETPYCISQALINAVKGDVENSLLFCGNDAY
                     KIDKLSTVEDVINELISEL"
     gene            complement(4330..4842)
                     /locus_tag="KR257_001465"
     CDS             complement(4330..4842)
                     /locus_tag="KR257_001465"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434028.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flavin reductase family protein"
                     /protein_id="HBH0030174.1"
                     /translation="MSDFKEILAEEIKNNPFGLIGKDWTLITAENEGKVNTMTASWGG
                     LGVMWGKDVAFVVIRPQRYTKEFIDNTDKFSLTFFDEDFRKELSYCGKVSGREEDKIS
                     QIGFNIEHLNDTPYFKEAKMAIICKKMYSQKLEPQCFIAEGIDGRWYPQKDYHTLYIA
                     EITNVLVKED"
     gene            5362..6297
                     /locus_tag="KR257_001466"
     CDS             5362..6297
                     /locus_tag="KR257_001466"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424475.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="magnesium transporter CorA family protein"
                     /protein_id="HBH0030175.1"
                     /translation="MIRYYKTIDSKLEKLSFFEDGCWINLVEPNHSEINEISNLLNID
                     VESIESALDEEERSRIDVEDNHTLILIDIPVDESDSNSSHYTTIPLGIILTEEAIVTV
                     CDAQTKILNDFIVGHIKDFFTFKKTRFLLQILHKNAAYYLHYLRKINKMTIIIEREIY
                     KSMKNKELVQLLELEKSLVYFSTSLKSNELVLNKMVRTAGIKKYPDDEDLLEDVIVEN
                     RQALDMAKIYGDILSRIMDAFSAIISNNQNNVMQILTVVTLIFSIPTIISGFFGMNVI
                     NMPFSNNPNGFWIILLITSIICIVITFFMSRNKLL"
     gene            complement(6389..8260)
                     /locus_tag="KR257_001467"
     CDS             complement(6389..8260)
                     /locus_tag="KR257_001467"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434025.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sel1 repeat family protein"
                     /protein_id="HBH0030176.1"
                     /translation="MKNTKFSIKKIKNISNDPKVVHTKGALLEKMGKMESAIELYKSA
                     ALDNYVKSQYTLGNIYESKKQFKEAEKWYSMAYKSGSEDAAFDLGNMYYKLDGYEYAI
                     YWYEKIANLGYLQAQNNLGVCHFKMKDFVRCEKWLKTAADKNLGKACFNLGVLYTFLE
                     KDDEAYEYYKKGSVLLDDDAKYNLAILNGKKKDNKSTVSLYKQLYKSGHMKGCFNLGM
                     IMEINDNLEDAEKYYKKSADRDDVKSEYRLAYVYDRKEELGDAIYYYEKAIEKNHTLS
                     KYRLANLYNRENEIEKAKTYYKMAAEDDITEAKNNLAGIYFEEKDYENAIKYYEDAIA
                     VGCKSSLENLGDLYYQNQDIEKAISYYSRIPNNVSCQIKLGNIYEDLNNIEEAISWYK
                     KASENGDTRSSYRLGCIYESLGNTKNARKYFEMASSKNHMNARIHLGRIYFREGKLEE
                     SKMMFDTPANENNVYAQHMVGLIYDMFYKDYVNSKFWYEKARAQGCVESIYNLGQIYL
                     KLNDDAEAEKYYKEGIKYGSKKCEYMLAGLYYKKSLDMYISLANEEYDNCEEIVEGFP
                     NLNIDFDEVLIPPFKLQEEVIDEEEYVPIYILNIKESLDSMLEGLETEMIIDEEHDS"
     gene            8450..9376
                     /locus_tag="KR257_001468"
     CDS             8450..9376
                     /locus_tag="KR257_001468"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424480.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AEC family transporter"
                     /protein_id="HBH0030177.1"
                     /translation="MNFSNIFIQVAVLFIIILVGYFVRKFNLLDDHCTSKLSTLTMTV
                     FLPSMIISSMQINFDSKMIQKILLLLFTSLIMYIVSIIIAFLLKYILKCNDKKDLGIY
                     QYIVVFSNVAFMGYPVIEAVLGHEAIFYTAIFNLPFNLFSFTLGIYLLSKGSTSRGFS
                     IKSLISPATIAIVIGLFLFVTGLRLPQFINEPLEMLGSITTPISMIIIGSLLANSSAL
                     DCFVNKKLYIVTFIRLLVLPVIVYFILKGWINDKMILAIPVVISSMPAAANTAIMANQ
                     YDSNITLASQCVFFTTLFSVISIPFISILLLS"
     gene            9515..9661
                     /locus_tag="KR257_001469"
     CDS             9515..9661
                     /locus_tag="KR257_001469"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890260.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0030178.1"
                     /translation="MDMDLLFKIVFAIVAIGVSVKIIKTVASLAFKIALILLIILFVY
                     RMFL"
     gene            complement(9766..10290)
                     /locus_tag="KR257_001470"
     CDS             complement(9766..10290)
                     /locus_tag="KR257_001470"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009905767.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HBH0030179.1"
                     /translation="MSKPIDITIRPIRREDAQAFNEIRRTYSVMRNTLALMSDRVDKT
                     EAMLASLGENDYMFVAETNNNGEKDVIGFAGLHVNSSPRLRHSAEIGISVAENYQGRG
                     VGKKLMEQLLDIADNWIMLTRVGLEVIVDNEKGLNLYKKLGFEIEGTKKYAVIRDGKF
                     EDVYIMGRYNKNLI"
     gene            complement(10343..10567)
                     /locus_tag="KR257_001471"
     CDS             complement(10343..10567)
                     /locus_tag="KR257_001471"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434018.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0030180.1"
                     /translation="MIIKLTKDNFNFRFKQYEGMFFHAEVVEGMESIRYKITKDKEGT
                     ELKEFGSTHIKDNMIYVPQVEAYIDLNSIK"
     gene            10764..11888
                     /locus_tag="KR257_001472"
     CDS             10764..11888
                     /locus_tag="KR257_001472"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861460.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3810 domain-containing protein"
                     /protein_id="HBH0030181.1"
                     /translation="MSKKTKYFSLILFPIALLLNFIASKVPNIVEKYYSQFIDKIIVQ
                     ILSKVSGIFPFSLYEITMYIIVISIFLFLCCTLSTIFNKKKKLNIYLKNSILNILSIV
                     SIVYFLFVVLWGINYNRIPLETTLINNYNLKNNTSIQSKQYSVKELTKLYKFLVIKAN
                     ETRKLTLQDKNGIVKSNTDYNGVINRAQLGYDNILDILPGVSGSYSKPKYIISSNLMC
                     YTGITGIYFPFTGEANVNIAIPDLYIPCTVEHEMAHQRGFASEDEANFIAYLTSIKHP
                     NIDFNYSGYILALNYTASALSKVDYNAYVDISAGISDSVRRDLKNESEFWQKYEGKIN
                     EISNEFNNSYLKANSVTEGTQSYGKMVDLLLTYYELYPYN"
     gene            complement(12362..13186)
                     /locus_tag="KR257_001473"
     CDS             complement(12362..13186)
                     /locus_tag="KR257_001473"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893472.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0030182.1"
                     /translation="MRYKKISSLPILVVALLITGTTTTFSLSTTNSEKTNVYLANTVS
                     TVTKKVSDIQSSKGLVYNENIPLFINNSKIQYDDTPYHWPSNVISLTNSSEKAIMDYE
                     ITCLAYDKNGKPLELYWDAQNVAADGEVGSVGFSPAGVDYGIVTGISPVFPKSYSHTY
                     RKMQQSPPQDIISMFEKQQGKAWVENWLKEWKQMEKEYAKQNAIAPGKNQNDAFLLFD
                     KWKQSTGEHGVKYIISCVKQVTFNDGSVWKNSAYENWLKSFQGKEVSNSVLENYYK"
     gene            complement(13534..14589)
                     /gene="ispG"
                     /locus_tag="KR257_001474"
                     /gene_synonym="gcpE"
     CDS             complement(13534..14589)
                     /gene="ispG"
                     /locus_tag="KR257_001474"
                     /gene_synonym="gcpE"
                     /EC_number="1.17.7.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424490.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flavodoxin-dependent
                     (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase"
                     /protein_id="HBH0030183.1"
                     /translation="MSYERRKTREVSVGTVKIGGENPISIQSMTNTDTRDADATIAQI
                     KRLEEAGCDIVRVAVPDIKAAKNIAKIKSSVNIPIIADIHFDYKLALEAIEQGVDGIR
                     INPGNIGSIERVKMVVEKCKERNLKIRIGVNGGSLEKELLKKYGSATAEALVESAMGH
                     IKILEDLDFHNIVISLKSSDIYKTVDAYELISKKVDYPLHIGITESGSVHKGTIKSSI
                     GVGALLLKGIGDTVRISLTGDPVEEVIVGKQILRSLGLLNDKIKVISCPTCGRCNIDL
                     ISVVNEVEEKIGSMEKNITVAIMGCAVNGPGEAREADIGIAGGKGEGLLFKKGEIVRM
                     IDGNKLVDELLEEIEKL"
     gene            complement(14771..15775)
                     /gene="rseP"
                     /locus_tag="KR257_001475"
     CDS             complement(14771..15775)
                     /gene="rseP"
                     /locus_tag="KR257_001475"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424492.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RIP metalloprotease RseP"
                     /protein_id="HBH0030184.1"
                     /translation="MTIIAALILFSIIVLIHELGHFIFAKRSGIKVNEFSIGMGPKIY
                     SVKKDTEYSIRALPIGGYVSMEGEDEEQISPNSFGNKSILQRFSTIVAGPIFNIILAA
                     ILLVPVFLYIGSPTTKLGKIMPDTPAQAVGLQVGDKINKINGNSVKTWDEVANIINTS
                     SGGELKLSITRDGSDKVVNVTPKNNNGKYEIGIQPQREKDFLGSIVNACKTTVDMTKQ
                     MLTFLGQMITGRVPGGIGNAVAGPVGVIGMVSDAARTGIINVVYLAAVISLNLGIVNL
                     LPIPALDGWRILMLLLEAVRGGKKLDPNKEGMINVVGFGALMLFMLFITYKDILRLFQ
                     "
     gene            complement(15788..16942)
                     /locus_tag="KR257_001476"
     CDS             complement(15788..16942)
                     /locus_tag="KR257_001476"
                     /EC_number="1.1.1.267"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430604.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="1-deoxy-D-xylulose-5-phosphate reductoisomerase"
                     /protein_id="HBH0030185.1"
                     /translation="MKKISILGSTGSIGKQTLDVVRDNRDKFEIVAISANSNIELLLE
                     QIVEFKPKYVTVFEENKALKLKEMLPKNIEIEVLAGMEGLKIISSLDEVDVLLTAVVG
                     MIGLVPTLCAIKKGIDIALANKETLVTAGELVMKEAEKYNVNILPVDSEHSAIFQCLN
                     GENKKNIEKIILTASGGPFRGKKKGELANITKNEALKHPNWSMGRKISIDSSTLMNKG
                     LEVIEARWLFGVEQENIDVVVHPQSIIHSMVQYTDSSIIAQLGCPDMRLPIQYALTYP
                     DRMESSFERMNFSKFSTLTFEEPDLETFPCLKLAYECLKMGGTYSSVLNSANEVLVSE
                     FLEDKIGFYDIPYYIEKTLEVHSSISEPTLEEILETDRWSRAYVANLIKK"
     gene            complement(17106..17309)
                     /locus_tag="KR257_001477"
     CDS             complement(17106..17309)
                     /locus_tag="KR257_001477"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897277.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="HBH0030186.1"
                     /translation="MISYAPLWKLLIDRKIKKMEFVNISGISISVLGRLGNDKSVSMD
                     TMEKICLALDCKIEDVVEIKKSI"
     gene            17646..18227
                     /locus_tag="KR257_001478"
     CDS             17646..18227
                     /locus_tag="KR257_001478"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729118.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0030187.1"
                     /translation="MLYLLKINQFEKSYDIGIFKNEQSIYKFIAKIPFVKKDNSNFNY
                     TNYYMEFEDIPEYYEVNFNNYLYIITRFSFIPDGTEIFFTWEEIHCWDEKVATEKTFI
                     NGETLVDSYNFPNNEVKDYIQKRESLYIETKKYYEEKGLKIERHALGSEDGEYVELTN
                     DSILYLLDIEAVEIREQSKNIEEFLYKYKKRFK"
     gene            complement(18315..20126)
                     /locus_tag="KR257_001479"
     CDS             complement(18315..20126)
                     /locus_tag="KR257_001479"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434003.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional diguanylate
                     cyclase/phosphodiesterase"
                     /protein_id="HBH0030188.1"
                     /translation="MKKKYDFLIYSAIWLVIIILFIFSLYHSIEHIKIISHTGTIRSE
                     TQKVVKQELNNERNDDLIKRLDNILIKLRTGNGENGFQRCDNKEFQQKLNQMDSMWES
                     MKKEIIKVRNGASGDKLYKLSEEYSVLSNQIVFISEKHSNAKLYSFATALFIYLIFST
                     ISLLIWEYYNKKRFKRIFYTDNLTKIKNQVAFENRAIEILHNASNKEYVLLNIDIDNF
                     KYINDTHGYEYGDKVLIIVAAALSKTFNIKETCARIGSDNFVILAKYRDSLLEDIREM
                     LTNAIISELDMNVTQTISYCIGAYLVEIDNLGYKSINSIMDKANIAHKVSKTRGISST
                     VWYNENLLKQLQMENSIYNYMYKAIENEEFHMYLQPKFQISSLNVVSAEALVRWFSPE
                     LGFLSPDEFIPLFEKSGFIIELDFYMLKKACSFVRKTFMKKNQYTYPIAVNFSRVTIY
                     QNSFYQRFLDTVKEYEIPFKYIEIEVTESAFNEISQPVISILEELKKLGFLISMDDFG
                     SGYSSLSLLCSLSINGLKLDKSLLKETFNREKVYSIIQCIIEMSHRIGMSVVCEGIET
                     KKDLEFLNTVKCDVGQGFYFSKPIEEKEFFNKYVTKK"
     gene            complement(20950..21729)
                     /locus_tag="KR257_001480"
     CDS             complement(20950..21729)
                     /locus_tag="KR257_001480"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424527.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphatidate cytidylyltransferase"
                     /protein_id="HBH0030189.1"
                     /translation="MLTRIIASLALVPLFLFVVYGGIPLYIAETAIVYIALHEFYKAF
                     KIKDVHPIFIIGYLFSIYLAVKNIFNLPLEYTYAVIFILFLASIIYMLMGKNNVIDVS
                     ITFLGVFYIGVFLDFIIITINGFEKGSIYVWLIFVISFMTDIFAYFSGYLLGKHKLIP
                     KVSPKKTIEGAIGGIIGSTLCCILFGYLFGIDLLQLAIIGSIGSVIAQLGDLFASSIK
                     RYVGIKDYGKIIPGHGGILDRFDSVILVAPFVYSAIKFFIR"
     gene            complement(21742..22476)
                     /locus_tag="KR257_001481"
     CDS             complement(21742..22476)
                     /locus_tag="KR257_001481"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424529.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="isoprenyl transferase"
                     /protein_id="HBH0030190.1"
                     /translation="MNNNIIYDIDLNNIPTHIAIIMDGNGRWAKARFLPRTAGHKAGV
                     ETIRDIVKECSKLGVKHLTLYAFSTENWKRPKLEVDTLMNLLSTYLRNEIAELHQNNV
                     KVTAIGDISALPKTCIRELNSAKELTKNNTGVNLNLALNYGSRADIKNALIDIVKNCE
                     SGKIDINNIDEDIIKNYLSTKSIPDPDLVIRTSGEQRLSNFLLWEVAYSEFYFTDIHW
                     PDFKKEELQKAIYVYQRRDRRFGGLK"
     gene            complement(22505..22708)
                     /locus_tag="KR257_001482"
     CDS             complement(22505..22708)
                     /locus_tag="KR257_001482"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003433997.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0030191.1"
                     /translation="MKKYYNLLGLHVDEVKQYFDEQNINYTVKSIEGKKDKEKLVVPR
                     VIKISEIGDSVELIITYFSDSLV"
     gene            complement(22711..23268)
                     /gene="frr"
                     /locus_tag="KR257_001483"
     CDS             complement(22711..23268)
                     /gene="frr"
                     /locus_tag="KR257_001483"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430598.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribosome recycling factor"
                     /protein_id="HBH0030192.1"
                     /translation="MKLEIHKQLEEKMNGTIDALKFEFGTIRAGRANAQMLDKIRVDY
                     YGTPTPINQIGAISVPEPRILMISPWDKSAMHEIEKAIANSDLGLNPSNDGEVIRLSV
                     PALTEERRKELAKKASKAAEEFKVRIRNERRDANEKIKKMEKGGELTEDELKKAQDEV
                     QKMTDKFIKEIDTLLSKKEKDIMEV"
     gene            complement(23294..23998)
                     /locus_tag="KR257_001484"
     CDS             complement(23294..23998)
                     /locus_tag="KR257_001484"
                     /EC_number="2.7.4.22"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430597.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="UMP kinase"
                     /protein_id="HBH0030193.1"
                     /translation="MDKPMYKRVLLKLSGEALAGERGFGINNDVVNDIAIAIKKIQEI
                     GVEVAVVVGGGNFWRGRTSEGMDRTTADYIGMLATVMNAMALQDALENIDVATRVQTA
                     IDMRQIAEPYIRRRAVRHLEKERVVIFGAGTGNPYFTTDTTAALRAAEMEAEVILLAK
                     NVDAVYDKDPKVHADAKKFTELSYMEVIQKELKVMDSTATSLCMDNKIPIKVFELTTE
                     NIIRAVKGENIGTTVK"
     gene            complement(24083..24994)
                     /locus_tag="KR257_001485"
     CDS             complement(24083..24994)
                     /locus_tag="KR257_001485"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424535.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="elongation factor Ts"
                     /protein_id="HBH0030194.1"
                     /translation="MANITAQMVKELRESTGAGMMDCKKALQEAEGNMEKAVDLLREK
                     GLSKAAKKAGRVAAEGLVAIEMNDDNTVASMVEVNSETDFVAKNEDFKVFVKDAACMA
                     LATDKEDIASLLGETHKEGITLQEVLNNRVAKIGEKLDFRRFAKVVTNGQVAGYIHGG
                     GKIGVLVEMETEARDAKVLELGKDVAMQVAAMNPKYVSRDEVDAEYIAHETEVLTQQA
                     LNEGKPANIVEKMVKGRLEKELKEVCLLEQTFVKNPDITVKQLVADVAKAVGSDIKVV
                     KVVRFEVGEGIQKREENFAEEVAKQLK"
     gene            complement(25073..25786)
                     /gene="rpsB"
                     /locus_tag="KR257_001486"
     CDS             complement(25073..25786)
                     /gene="rpsB"
                     /locus_tag="KR257_001486"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424537.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S2"
                     /protein_id="HBH0030195.1"
                     /translation="MSVISMKQLLEAGVHFGHQTRRWNPKMAKYIFTERNGIYIIDLQ
                     KTVKKVEEAYKFTKEVAETGKPILFVGTKKQAQDAIKDEAERCGMYFVNERWLGGMLT
                     NHKTIKTRINKLRELEKMEEEGVFNVLPKKEVIKLRAEKEKLEKYLGGIKDMPELPGA
                     MFVVDPRKENIAIQEAHRLGIPVVGIVDTNCDPEQLDFAIPGNDDAIRAVKLITGAMA
                     TAVIEGRQGAEEEVAEDQE"
     gene            complement(25993..27177)
                     /locus_tag="KR257_001487"
     CDS             complement(25993..27177)
                     /locus_tag="KR257_001487"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890281.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="D-alanyl-D-alanine carboxypeptidase"
                     /protein_id="HBH0030196.1"
                     /translation="MKNALKKIISLAMILVFIIPNYSYADDKSVDKYSKTSILIDQET
                     GRVLYSKEPDMKVPLASLSKMMTFLLAIEAIENKEVKETDKVKIDKSIASVKGSSYKL
                     KDGEEVPLIELMRGLMIVSGNDAAIAIAKHVCKTKEAFVDRMNKKAKEIGMSNTHFLN
                     PNGLPIYDLSNPKKPAKENISTAKDIAILGKYMFDHYEKQVTAITDMETYTNSDRSFE
                     KSNTNALLRIIPEVDGIKTGYTGNAGYCLSFSMVVNKNDKNEKKRRVIGVVLGTNHKN
                     KRTSASLALLKYGKENFNMKKVIDKDSFIGKKYIKGTKELEVTLKAKDELYTILKDDE
                     SIKSEVKIKNIEYPVKKGDTMGIIKYYTNSGDLLGSVDIVSNNSIDNVSLKTKLKMKF
                     AN"
     gene            complement(27281..28339)
                     /locus_tag="KR257_001488"
     CDS             complement(27281..28339)
                     /locus_tag="KR257_001488"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003433992.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="potassium channel family protein"
                     /protein_id="HBH0030197.1"
                     /translation="MNCKWISKIDERKKCHREADSSGYCIFHKENKSDEEIQLMMDTL
                     HKEEISEFNGFVFENEFNAEEILTYNYKILDFSESIFKQKANFKKYIFKKNIIFNYTE
                     FRDKVLFNGCVFLENCDFNRTIFSKHYINDRIFEKVKFKGPDLVVNKVENFPRMDGII
                     FSMCTKFVLKNVEYGKSEYEHGKINYRIARNQATKIGEYEMIGFYYYKERIYSSKIMK
                     RSNYPTFSDYLVEKFFDQIARYTTGYGEKPWNILLVIIAIISVFALLYLFVGIESSNS
                     TLVALDINNIGDYSLSEIFKMYMDLWYFSMATFSTVGYGDMVATSLIGKALAGIEVFF
                     GVTIGAIWASVIIKRMIR"
     gene            complement(28553..29197)
                     /locus_tag="KR257_001489"
     CDS             complement(28553..29197)
                     /locus_tag="KR257_001489"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861468.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="HBH0030198.1"
                     /translation="MEQHSKVGNFGDLLKVLLDEKELSMGELSKKSGIDKSTISRIAN
                     NKQKPNINHLEKMAIHLNINLEELLKASGYEFRNSNNQIFNADSDFSNFDDILGFANL
                     INDKNFNGNIEKELSKCKLYVQTDEGKKLLFDNFNKKIDSIEKQGQFTDRLRQMYADF
                     CTDGLTIKKYLLIGSMLLYFVISTDVIPDFVFPIGFMDDLVALNIVTKLLKNDK"
     gene            29385..30008
                     /gene="ytaF"
                     /locus_tag="KR257_001490"
     CDS             29385..30008
                     /gene="ytaF"
                     /locus_tag="KR257_001490"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003433989.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sporulation membrane protein YtaF"
                     /protein_id="HBH0030199.1"
                     /translation="MIESILLVTSLCIDAFVTSFGYGVNKVKVPLYSNIIISVVCSAI
                     LAISLFAGTIVRDFLPQNITMLICFFILFLLGSARLIESFFKSYFKKKSIHSKNYNFN
                     MLDLKLNFNVSIEPDVLDTSKSKVLKSAEAFTLALALSLDGLAIGFGSGLVGVNYIQV
                     ILFSLISNIIAVLLGCLLGNMFVKNVNLNLSWLSGLILLVIGFMKIC"
     gene            complement(30071..31981)
                     /locus_tag="KR257_001491"
     CDS             complement(30071..31981)
                     /locus_tag="KR257_001491"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430591.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="endonuclease MutS2"
                     /protein_id="HBH0030200.1"
                     /translation="MNSNTFERLQLNEVKELIKIHCVSSLGKNLIDKLTPSGNIGVVR
                     RKLAENKEARKIIENSNHIPLEGLFNAGSTIDKIEKGMIIEPVELVNIEDFLRGCRKM
                     KAFMLEKEFYSPTLSSYALNITECKSIEDEINYCIKSNKVDSNASKELKKIRRNIEIT
                     EGKIKDRLNKFITSTVNKKYIQEFIISKRNDRYVIPIKSSYKNEVNGTILDTSSKGNT
                     VFIEPISVSNLSTELTMLKADETIEEYKILSYLTELIFEKISQIKLNIEILSEYDMVF
                     AKAKYSQKIKGITPKINNNGYIKIIKGKHPLLTGDAVPLDFEIGKNYRSLIITGPNAG
                     GKTVTLKTVGLLTLMVQCGFDISAKEGSEFSVFEKVFVDIGDNQSIENALSTFSSHIK
                     NIAEIMSLSNNSTLVLFDEIGSGTEPNEGAGLAISLLEEFYKMGCITIASTHYGEIKK
                     FATLHPEFENAGMMFDKETLEPLYKLTIGKSEDSNALFISKKMGIKNRVLDRAKEYVI
                     DRNYNLDLVKRSKLQSNIEDKNSSEVILNYTDYNVGDKVKLLDEDDFGIVYKPMDKFN
                     NVEVLFNDNFISVNIKRLQLSIKASELYPEGYDLDVLFTSFKERKLEKDIQRGSKKAL
                     KKIQKEIRENRK"
     gene            complement(32515..33582)
                     /locus_tag="KR257_001492"
     CDS             complement(32515..33582)
                     /locus_tag="KR257_001492"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890294.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RNA ligase RtcB family protein"
                     /protein_id="HBH0030201.1"
                     /translation="MSNIKIIASNKCWIEDIARKQLEDISKLNGILRVVGLPDLHAGK
                     IPVGLAVETKNIIYPHIIGNDIGCGMTLFKTGVLKKKFKKDKWIKSLSKIKDLSDIEI
                     KNTYKEECPILNLGTIGSGNHFVEIQCISEIYNKEQFEQLKFSSDDIMMLVHCGSRNY
                     GEDILKKFYDKDGLEVESEKAIDYIKKHDNALMWAERNREAISKKIMQSIGTSGDVET
                     IFSINHNFIEKREDKFIHRKGAVSSERGAVIIPGSRGSLSYIVMPTENTEISLYSLSH
                     GAGRKWSRSVCKSRLKSKYNKDTIKQTKFKSQIICNDVNLLFQEAPEAYKNIEQIIES
                     LIEYELIQVVATMKPLITYKG"
     gene            complement(33828..34823)
                     /locus_tag="KR257_001493"
     CDS             complement(33828..34823)
                     /locus_tag="KR257_001493"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424555.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="protein kinase"
                     /protein_id="HBH0030202.1"
                     /translation="MYEEVTWLNFIGNRYEVVNSDDVLEINKIYKARDVFYRKNVLIK
                     VIKHNNYICEDFVSNLIDESTALDEINSPYILKIIDVGIHCTEETTLYYVVSEDFNGI
                     GLDELILGNYLHLEAIVNIMIQVLKALEMIHRNHSYHGSLKSSSIIVDTEYNIKICDF
                     GITKANNGVNTRSYGNRRYLCPHQLCINYTDKESDFFATGLILFESIFKKLPFGESNS
                     EEKMLQSIDKGLDWNSIKAINGNTELINVIKRLLGRNNKYTRANDIIIDLSKVMYEKA
                     YIEVEDEKEEEQKQDKVIQVKKEYKSKMRKKLHKKLVVAGLAIVMISMIIISSII"
     gene            complement(35082..36341)
                     /locus_tag="KR257_001494"
     CDS             complement(35082..36341)
                     /locus_tag="KR257_001494"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861472.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="VanW family protein"
                     /protein_id="HBH0030203.1"
                     /translation="MGRRTTRVSRLGKEKKRSVLIVLAALVLIMGGFTYFFNSKFLYN
                     GKIAKNVYIEGVNVSDMTKAEALKAITDKYTPEDLNLAYDGKKYTISPKDIDLKYDTE
                     DVVKDAYESTKKGSYFQNLKKYIDIRVNKANMKIKAEYDEAKLSSKVSSIADSINVKM
                     KNASISVGSGGLSYTDSVVGREFDLAANKESIYNMIKNKEHKTLELKVNLQKPDITTE
                     QVKTVNSVIGQYSTTYSQAVEGRSYNVGLSARKTSDVLLMPGEEFSYNKLTGPSNKAN
                     GYKDAPVIVYGKLEQSAGGGVCQTSSTVYNAALLSGMEITQVTNHSSASTYVPKGRDA
                     TVSDGGLNLKFKNPYKHPVYIKNYAGGGSVSSVIYGNSGDKPNISIEVKQTGQNKYST
                     YRIFKDSSGKVIKKEHISNSSYKELKK"
     gene            complement(36581..37210)
                     /locus_tag="KR257_001495"
     CDS             complement(36581..37210)
                     /locus_tag="KR257_001495"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424558.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="endonuclease/exonuclease/phosphatase family
                     protein"
                     /protein_id="HBH0030204.1"
                     /translation="MKIVTYNIHKGMDSNNRLTLTKMGLYLKQLDCDVICLQEVLYPQ
                     FLALKAVLNMGGVFATNVKKVNMIYGICTFTTSKMLNSNHFFLTSKKEQRGALCITID
                     AYGRIINVINTHLGLDRQERAKQLDEIIDYRNRLVGIVILCGDFNEKNVFLSMFNDMA
                     ISLNKSYLPTFEKSNSRIDYIFVNKNTELKGYTVEKIYLSDHYPVIGYI"
     gene            complement(37403..37564)
                     /locus_tag="KR257_001496"
     CDS             complement(37403..37564)
                     /locus_tag="KR257_001496"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424559.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0030205.1"
                     /translation="MIIPSRRIQDITLTNLKNGEVTLIELDEIYKKMGFLFVVSEGKL
                     KKIKKENHH"
     gene            complement(37907..39067)
                     /locus_tag="KR257_001497"
     CDS             complement(37907..39067)
                     /locus_tag="KR257_001497"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430586.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF819 family protein"
                     /protein_id="HBH0030206.1"
                     /translation="MIETGFVYCSFLVVFVGVIFFMVDKLKWKVFDVINPMLLIYLGS
                     AILGSFGLFAQNEDVGTYQNIITVNFLPLMLVFLLIQCDLRKILKMGPKMLLSFFCAT
                     FTFMLGFVIAFIIFKNSMGADSWKILGAASGSWIGGSSNMIAAANALGVAEEGLSYAI
                     LMGSIGYTVWMSVCLMSVKFGPKFNKWTKCDTSFIDEVTSKLEKENKDNTAPTFVELM
                     ILLSVGFGVASFAQIVSKILPTSGILNETMWVVLVASTVSILLGMTKISKLKGSTLVG
                     NVFMYLLLAATGSKANFFGLSEAPVYIMFGLVVVLVHAISFIGLAKLFKLDLFTCEVG
                     SIANIGGVTTAPMIAGVHNPVLIPVGVLMGLLGNIIGTYCALMVTQILHMLA"
     gene            39537..40577
                     /locus_tag="KR257_001498"
     CDS             39537..40577
                     /locus_tag="KR257_001498"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424562.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="M42 family metallopeptidase"
                     /protein_id="HBH0030207.1"
                     /translation="MNLNLTNTINLMKKYLDIPSPAGYTENAVLEIKKDFENLGLDTI
                     LTKKGALIATLPGEDDSNQITISAHMDTLGAIVKEISSDGTLKYHKVGGGCWAAIEGE
                     NCTVITRKGKKIRGSVVFKYASTHIYGQTKAATERNEETMIIRLDEKVFTKQDVLDLG
                     ISVGDFVCLDHRFEATESGFIKSRYIDNKSAVAMVLEICRYFKENNLTPKHTTNFYIS
                     NYEEIGHGVSKCLPEKTKEFVAIDIAPTGPSQTSSEHGVTIVAKDNLSLYDFNLRNKL
                     VDVAEDNNLDYAVDVFTFYGSDASEAIRWGEDVQIACVGPGTNNSHHYERTHIEAIEN
                     TLKLLINYMLKE"
     gene            40958..41209
                     /locus_tag="KR257_001499"
     CDS             40958..41209
                     /locus_tag="KR257_001499"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003361768.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="iron-only hydrogenase system regulator"
                     /protein_id="HBH0030208.1"
                     /translation="MKKVAVISAILEEPKECQFKFNEVVSGFKGIIKGRMGIPCEEEG
                     VSIVCIAVVGEMDTINSLTGKLGNIPHVSVKTSISKKEV"
     gene            41224..42432
                     /gene="hydF"
                     /locus_tag="KR257_001500"
     CDS             41224..42432
                     /gene="hydF"
                     /locus_tag="KR257_001500"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729114.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="[FeFe] hydrogenase H-cluster maturation GTPase
                     HydF"
                     /protein_id="HBH0030209.1"
                     /translation="MSLNSTPQSVRVHIGLFGKRNAGKSSIINAITNQSAAIVSDIAG
                     TTTDPVFRPMEILPIGPCVLIDTAGLDDVGELGELRIGKSLDVLEKTDIALLVVDCQI
                     GISQEDLSLIEKFNDKNIPHILILNKIDTIKNQSEILNLTKNKVKCPVVSVSSTDKIG
                     IENLKNEIIKVLPKDSTEFKLVSDLIEPNDLIVLVVPIDKAAPKGRLILPQQQVIRDI
                     LDSGAISIVTKEDSLKETLSNLGKKPKLVITDSQVFPQVDKDTPKDIPLTSFSILFAR
                     QKGDLKELINGAYALENLKDGDKILMAEGCTHHRQTDDIGTVKIPNMIRKKTGKNITF
                     EFSSGVSFTEDINKYALVVHCGACMMNRAGMLSRIEKAKSFNVPIVNYGILIAYVKGI
                     LERSLELFNY"
     gene            42468..43553
                     /gene="hydE"
                     /locus_tag="KR257_001501"
     CDS             42468..43553
                     /gene="hydE"
                     /locus_tag="KR257_001501"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424566.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="[FeFe] hydrogenase H-cluster radical SAM
                     maturase HydE"
                     /protein_id="HBH0030210.1"
                     /translation="MTKNKIKYFIDKLYSINSLSFDELLYLIENIDNEEYNFEQNLRN
                     YLYKQASDMRNKHYGNRVYLRGLIELTNYCKNNCYYCGIQSSNKNIIRYRLSLDEILE
                     CCDIGYKIGYRTFVLQGGEDAYFTDDKICEIVSSIKNKYEDCAITLSLGEKSYDSYKK
                     YFLCGADRYLLRHETATDSHYKKLHPPNIELRTRKECLKNLKEIGYQVGAGFMVESPF
                     QNNEDLVRDLLYLKELNPHMVGIGPFIPHHDTIFKDYKHGDLEKTLLMLSITRLLLPK
                     VLLPATTALASINPSGRNAGLLAGCNVIMPNLSPQEFRKQYSLYDNKAFTGQEACEYH
                     QSLEENIKSLGLEVDYSRGDNIEWRRL"
     gene            43554..44930
                     /gene="hydG"
                     /locus_tag="KR257_001502"
     CDS             43554..44930
                     /gene="hydG"
                     /locus_tag="KR257_001502"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430581.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="[FeFe] hydrogenase H-cluster radical SAM
                     maturase HydG"
                     /protein_id="HBH0030211.1"
                     /translation="MFINHELINSLLEDAKNSTSDDIEKVLDKADRREKLSYKDIATL
                     LEVEDKKQLDRLFSIAGQIKNEIYGNRVVLFAPLYVSNYCVNECVYCGFSKCNKFKRK
                     KLTMEEIREEVKILEKMGHKRLALEAGEDPKNCDINYILDCLDAIYSTYNENGNIRRV
                     NVNIAATSVDEYKLLKEKGIGTYILFQETYHKPTFIKMHGQSIKNDYYYHLTAFDRAM
                     EAGVDDVGAGVLFGLSDPKFEVLGLMMHNEHLEEKFGVGFHTISFPRLKKAEGMSLED
                     FPHLVSDDMFKKIVAITRLAVPFTGIIMSTRETAEMRNELLKYGVSQISAGSLTGVGG
                     YKAYEDGDNTEQFEVGDHRSPVEVLKELITDGYIPSYCTACYRKGRTGDRFMSLAKSR
                     QIHNVCTPNALTTLNEFLIDYGDEELKIMGKKLIAEEIGKIEREDIRNIVSNNMTALE
                     RGERDLYL"
     gene            45021..45449
                     /locus_tag="KR257_001503"
     CDS             45021..45449
                     /locus_tag="KR257_001503"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430580.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0030212.1"
                     /translation="MKDNNNTNKTIQFGEKKASLENNIQKNKNIKLDNTHKVIPYPKN
                     RKKDDKKKGNKKKNTNTSKVNKNNYGHSFFNNKYKYKRKPYVIALYTVILILLAILII
                     TKLTDSTNKGNYSRNTVSDTHKNDIRNIVFNESNNFLICG"
     gene            complement(45524..46843)
                     /locus_tag="KR257_001504"
     CDS             complement(45524..46843)
                     /locus_tag="KR257_001504"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893495.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aminotransferase class III-fold pyridoxal
                     phosphate-dependent enzyme"
                     /protein_id="HBH0030213.1"
                     /translation="MSEITSQMISTEEKKYVAKTQKIPYYPVAFKSGDGAMLYDYEGN
                     EYVDFLASAGSANVGHGNKEISQAVKEQMDDITQYTLAYFHSDPPVKLAEKLVEIAPG
                     DNDKKVLYSATGSACIDAAIKLARGYTGRTKIISMCESYHGSTYGAISISALSTNMRR
                     KMGPLLPEVYHFHYPDKNRTAKECLDEIEYAFAHYLPAEEVAAIFIEPIAGDAGIIVP
                     PVEWVQGLSKICKENGILLVSDEIQQGMGRTGKWFGIENFGVEADLIVLGKSVGGGLP
                     LGAVVGRTEIMQSLDAPAHLFTLAGNTTVCVAALKSIEIIEKENLLQKSIEMGDYIKA
                     GFEKLKEKYDIIGEIRGIGLSIGVDIVKGKGSNEKHPDATAKICYRCIQTGLIMIFLG
                     QSTLRVQPPLVITKEQVDKAMNIIDSAIDDYLNGRIGDEVYEVTQGW"
     gene            complement(47135..47920)
                     /locus_tag="KR257_001505"
     CDS             complement(47135..47920)
                     /locus_tag="KR257_001505"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003433968.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0030214.1"
                     /translation="MEIIKYILYFFIYSFLGWTVESIGCSIASKRIINRGFLNGPICP
                     VYGFGAVIVISLLGRFNNVVIVFLLGMILTTILEYFTGFILETLFHAKWWDYSDKKFN
                     IKGRVCLKNAIYFGVMSVLIIRFIHPFIKYFVSIIPYRILISMAIITTLWTILDLIVT
                     IITLKKLDIKLNLLDDIITDLNDINVKLDKFDRGEIQALFKTINNDELEVREKINKIN
                     SKLDRIESNIILQKRVIKAFPHIKHKKQQEQLEHFKKIINEKR"
     gene            complement(48035..48994)
                     /locus_tag="KR257_001506"
     CDS             complement(48035..48994)
                     /locus_tag="KR257_001506"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897306.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="VanZ family protein"
                     /protein_id="HBH0030215.1"
                     /translation="MIESKKSEKLLLSIIYIIFLVYILMIIRIILFRDVPIYAIFKGT
                     FRNVNLIPFYTIYQFIVDSNLDFMKATVNIIENIGIFIPMGIFLPIVCKNLNKKTIII
                     VIILVSLAFELTQYIFALGSSDIDDVILNSLGGIIGINIYINMNKLFPNDINRFKAII
                     GTSLVLGVIGLGVISKNYHNLLTFKFRPDRKISKILIEENREIIKDINKDTVDIVGTF
                     ESFKKGIITIKAGSNNKVKRPENLIDSDGNIRIYLNENTKLVSYIITKESKMDIVKYE
                     EFDVKNLDLLRRYDTINVWIDKENQPKDKHGIMASKLLIGLYE"
     gene            complement(49152..49469)
                     /locus_tag="KR257_001507"
     CDS             complement(49152..49469)
                     /locus_tag="KR257_001507"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430572.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0030216.1"
                     /translation="MGVLKGMFYVFLFLDLVSIFCFFFNKGKIASNKIVFNAIGVLTF
                     VLCFMLFSYYPNNNLIGKFIASLFFIFGVAGVMLKEKNFLYARLLLTVVIVFSTLRLF
                     VIQ"
     gene            complement(49576..50079)
                     /locus_tag="KR257_001508"
     CDS             complement(49576..50079)
                     /locus_tag="KR257_001508"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893498.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HBH0030217.1"
                     /translation="MEQQKDYIELYENEELIEIREARMDDLDTIAKFNYNLAKETEGK
                     ELDMDVLTKGVKALLLDERKGKYHVYTVFDKVVAQIMYTYEWSDWRNGNFLWIQSVYV
                     DKEYRRKGIFNYLFNYIKNICDKDENIVGMRLYVEKENINAKATYESLNMYECDYNMY
                     EYEVIHS"
     gene            complement(50131..51330)
                     /locus_tag="KR257_001509"
     CDS             complement(50131..51330)
                     /locus_tag="KR257_001509"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003433961.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alanyl-tRNA editing protein AlaX-L"
                     /protein_id="HBH0030218.1"
                     /translation="MEKLYYTNQYIRDFTAEIIEIKEVENKYHVLLDKTAFFPGGGGQ
                     FGDLGKIESDDVINVYEDGKKIYHVLDKKPIKIHKVKCSIDWDRREDGMHQHFGQHVL
                     SGCFFKTFNANTTGFHLGNEYSTVDIEGNLEEDKIREIELFANEIIRQNIQVETLLPT
                     KKELKKIWLRRDLPNTDEEIRVIKIGDLDTNACCGVHPKSTGELRMIKIKKWEKHKSS
                     TRIEFLAGKRAVDEVLKRDIYLTKICRYLSCSEEDAINGIVNLNSKVEEALIKKRRLE
                     EVVSTYQVKEMIEKANKVGNISVIKKIYDDEDLKYVNKIANKIAEYENSIALLAVKFN
                     DKINLVFACSKNLKDINMGVLLKDAISLIDGKGGGSKVLAQGGGKNNGNLEATLDYAF
                     MKIEKTL"
     gene            complement(51590..51778)
                     /locus_tag="KR257_001510"
     CDS             complement(51590..51778)
                     /locus_tag="KR257_001510"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861476.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0030219.1"
                     /translation="MNYHTKEELVEALRVVSSSIINCGKGQKKFSEETSHHTRFKNII
                     EVMYISKSLIMDEISKRD"
BASE COUNT        17667 a         8273 c         5773 g        20260 t
ORIGIN      
        1 aaactttttt tgtaatatag tgtagtataa aattgtaata ttacagatat ttaatagtta
       61 tcttttgatt actttcatta aaaacagctt catcactatg aaaatctagg tttttaaact
      121 tttaaaaaag ttaaaaaaat atttttctaa tactcaattt gattacaatt tttttacaat
      181 ttaaaaaata ttttttccaa atttttatat taatacttga ctttgtctgt tttataaact
      241 agaataatta ataatattaa gaatattgaa aggcattgat taggaagagt aaatctgaat
      301 cgattaccag agaaggaaac tactagctga aatgtttccc taattagaag gattgaaaac
      361 tacctaggag cttctatccg aagttatctt aatgatttta gtaggaatag acgtttttat
      421 tacttgcgtt aaagtatcaa gtggattttt taaaatcaat ttgggtggaa ccgcgggaaa
      481 cagattctcg tccctttttt agggatgagg gtcttttttt attacctaaa ttcagttttt
      541 aaaatattct gtatctaatt taattagcta attaaaaatt taaaatatat ggaggattat
      601 aaaaaatgta ttattcaagt acgagaggca ccgaagaaaa agtaactgca tcacaagcaa
      661 taataaaagg aatatcaaat gatggtggtc tttatgttcc aagtgaattt cccaatgtaa
      721 aaaatgaact tataaattta gtaaatttaa cgtattctca gatagcattt tttgtactta
      781 gtaaattttt atgtgatttt actgaagatg aaattaaaaa ttgtatagaa aatgcatatg
      841 atgaaaagtt tgattgtagt agtatagctc cattaaataa agtaaatgat acttatttct
      901 tagaactata tcacggtcca actttagcat ttaaagatat ggcacttact ataatgcctc
      961 atcttcttaa aacatctata aagaaagata atttagagaa agatgttgtg attcttactg
     1021 ctacatctgg agatacaggt aaagctgcac ttgagggatt taaagatata gataaaataa
     1081 agataattgt attcttccca gaagatggtg taagcccagt acaaaaactt caaatgaaaa
     1141 ctcaaactgg aaaaaataca tatgtagttg gtataaaagg aaattttgat gatgcacaat
     1201 caggtgtaaa gaagattttt tctgataaag aatttaatca aaaactattg gataataatt
     1261 atatattatc ttctgcaaat tcaattaata taggaagact tcttccacaa gttgcatact
     1321 atttttattc atatatgaaa ttagttagca atagtgatat aaatttaaat gataaaataa
     1381 attttgttgt cccaactggt aattttggta atattctagc tggatattat gccaaacaaa
     1441 tgggtcttcc aataaacaaa ttaatatgtg catcaaatga taataatgtt ctttatgatt
     1501 tctttaaaac tggtgtatat gataaaaata gaacattgaa attaactact tctccttcta
     1561 tggatatatt aatttcaagt aatttagaac gattactgtt tgaaatatca aatagaaata
     1621 ctgatattgt aaataagctt ttatcagacc ttagtgataa aggagtctac aaaataagtg
     1681 atgatatgga aaaaaattta gcctcattct atggagaata ttcaaatgaa gaagaagtta
     1741 aaagcacgat aaacaatgtg tttaaaaatt ataattattt gatagatact catactgctg
     1801 ttgcatacaa ttgttatgaa aaatataaaa aagaaacttc tgataacaca aaaactgtta
     1861 ttgtaagtac tgcaagtcca ttcaagtttt ctgaagatgt tctaaagtct atagattgtg
     1921 attttaaaga ccttgatgac tttgctataa ttgatagatt atcaagtatt tctaaaatag
     1981 atattccaaa acctattaaa aatcttaaaa atgcagaaat actacataaa gatatttatg
     2041 aaaaagatga attaaaacta gctataaaaa aattcttaaa ggtataggtg attattatgt
     2101 tagagattat agttcctgca acaagtgcta atataggtcc aggatttgat tgtcttggaa
     2161 ttgcgttaaa tatatacaat aaattttatg ttgaagaaat tgaaagtggt cttgaaatag
     2221 aaggttgtga agatgcttac aaaaacgaaa acaacttagt ttatacatct atgaagtact
     2281 tttttgatag agttaaacca gaaaaaatac ctgctggtat caaaataaaa atccaaagtg
     2341 aagtacctat atgtagaggt cttggcagta gtgcctcttg tatagtagct ggagttatag
     2401 ctgcaaatgc tctatcaggt gctaatttag ataaaaatca attactaaat atagcttcag
     2461 aaatagaagg tcacccagat aatgttgctc ctgctatttt aggaaatatg attgtatctg
     2521 ttactgataa tgagaatata cattatgata ttataaaaat tcctgaagaa cttaaatttt
     2581 gtgcaatgat acctaatttt aagttatcaa cagaaaaagc tagaggtgtt ttaccaaagg
     2641 aaataccata ttctgatggg gtattcaatg ttagtagagt tgctttacta atatctgcct
     2701 tactaaacaa aaactttgac ctacttaaag tagcttgtca agacaaattg catcaagatt
     2761 atagaggaac tctaattgag aactacaatg atattgttga aaaatctgaa caattaaata
     2821 gtattggagt atttttaagt ggagctggac ctactataat gtctttaata aaagaaaatg
     2881 atgatagttt tgtggataat atgaaaaatt acctacaaaa actaaaatct gattgggaaa
     2941 taaaagagtt atgttgcgat tctaatggag ctgttttaaa tataatataa ttatcgtctt
     3001 ctatacaaaa tataactact cttttattat aatttgtagt ataataatta ggactaggta
     3061 ataatattaa gtattataat ctagttcttt aaacatgttt acattgagga gggattatca
     3121 taaaagagtt aataattaga gatttagttg caaaagttcc tataattcaa ggtggaatgg
     3181 gcgttggtat atctaggtca tcactagctg gtgcagttgc taagcttggt ggtgttggtg
     3241 taatttctgg agttcaaatt ggatatgatg aggaagattt tgaaactaat actataaatg
     3301 caaatttaag agctataaaa aaacatattt ctaaggccaa agaaatctca aatggtggta
     3361 ttattggtat taattttatg gtagctatga aagaatatga aacatacgta aaggaagctg
     3421 ttaaagctgg tgtagacctt ataatatctg gagctggatt acctaataag ctaccatcat
     3481 tagtaaaggg aagtaatgta aaaatagcac ccatagtttc aactgcaaaa gctgctaatg
     3541 taattttaaa aatgtgggat agaaaagaga aaactactgc tgacttaata gttgttgaag
     3601 gtccaaaagc tggtggtcac cttggatact ctaacgagga acttgataac atagattcta
     3661 tagactatga taaggaattt gttgaaattt taaaggttgc aaatacttat ggagaaaaat
     3721 ttggtagaaa cataccagta gttgctgctg gtggtataac ttctagtagt gatgttaaaa
     3781 aatatataga tatgggtgca agtggtgtac aagttggtac aagatttgtt gctacttacg
     3841 aatgtgatgc ccatgagaac tttaaaatgg catacataaa tgctagtgaa gaagatgttc
     3901 atatagttaa aagtcctgta ggtcttcctg gacgtgccat aagaaacaaa tttatagaag
     3961 aagttaaaat aaatcgtcca gaaataaaga agtgctataa ttgtttgatt ccttgtaatc
     4021 caaaagaaac tccttactgt atttctcaag ctctaatcaa tgcagttaaa ggagatgttg
     4081 aaaattcact tttattttgt ggaaatgatg cctataaaat tgataaatta agtactgttg
     4141 aagatgttat caatgaattg atttctgaat tataatttaa agaaaactaa attaaaattt
     4201 tatcaagcta aggagtttaa atacgttatt tattaatctt tataaacata tttatgtcct
     4261 tagctttttt gtgtcaattt ccttttattg aaattttaat ttaattagag atagtattaa
     4321 cccttataac taatcttctt ttacaagtac attggttatt tcagctatat ataaagtatg
     4381 ataatctttt tgtggatacc atcttccatc tataccttca gcaataaaac attggggttc
     4441 aagtttctga ctatacattt ttttgcatat aatagccatt ttagcttcct taaaataagg
     4501 tgtatcattt aagtgttcta tattaaatcc aatctgtgat atcttatcct cttctctacc
     4561 agatactttt ccacaatatg aaagctcttt acgaaaatct tcatcaaaaa atgtaagaga
     4621 aaatttatct gtattatcta taaattcctt agtataacgc tgtggtctta ttactacaaa
     4681 agcaacatct tttccccaca taactccaag ccctccccag ctagcagtca ttgtattcac
     4741 tttaccttca ttttctgctg ttataagtgt ccaatcttta cctatcaatc caaatggatt
     4801 atttttaatc tcttctgcca aaatttcttt aaaatcactc atatctctaa taacctctca
     4861 ttctcttata tttatattcc ttttattttc atgataaatt ataaatgaag tctagttttg
     4921 aaaataaaat acttttttaa atatattatt gcaaataagt aaatatatat atacactctt
     4981 attttttaat atatttaata atttcactca gaatatatat attctttact caaattaaat
     5041 ataacttata tactttatgt gtaaattatg gtaaaaatat tatttaatca aatcaaaact
     5101 tgatttatat acctggaaaa ggtattatat taaagagtgc ttaaaatacg catttcataa
     5161 atagctatat ataaaataat aaataaggag agtgatgggc aatggatact agtccgttgc
     5221 ggagagaatt ttttacattt tcatcactta ataatatcta aaatcaaaac taatacatat
     5281 attcagttat ataaattagt taattaatag atactattaa atgatgagat ttatataaaa
     5341 ctgaataaag gatgtgttgc catgataaga tattacaaaa ctatagattc aaaattagag
     5401 aaacttagtt tttttgaaga tggctgttgg ataaatcttg ttgaacctaa tcatagtgaa
     5461 atcaacgaaa tttctaattt attaaatata gatgtagaaa gcatagaatc tgcactagat
     5521 gaagaagaac gctcaagaat agatgttgaa gacaatcata ctcttatact tatagatata
     5581 ccagtagacg aaagtgactc taattcttct cattatacta caataccctt aggtattata
     5641 ctaactgaag aagctattgt aacagtttgt gatgcacaaa ctaagatttt aaatgacttt
     5701 atagttggtc atattaaaga tttttttacg tttaaaaaga ctcgcttttt gcttcaaatt
     5761 cttcacaaaa atgcagctta ttacttgcat tacttaagaa aaataaataa aatgacaatc
     5821 ataatagagc gagaaattta caaatcaatg aaaaacaaag aattggttca attattggaa
     5881 ttagaaaaat ctttggtata cttctctacc tcactaaaat ctaatgaact tgttttaaac
     5941 aaaatggtta gaactgctgg tataaagaag tatccagatg atgaagacct attagaagat
     6001 gttatagttg aaaatagaca ggctcttgat atggctaaaa tatatggaga tatattgagt
     6061 agaattatgg atgctttcag tgcaattata agtaataatc agaataatgt tatgcaaatt
     6121 ttaacagtag ttacactaat tttctcaata cctacaataa tatcaggatt ctttggtatg
     6181 aatgtcatca acatgccatt ttctaataac ccaaacggat tttggataat acttcttatt
     6241 acctctataa tatgtatagt gattacattt ttcatgtcaa gaaataagct attataaaat
     6301 attaataaaa aagccattag aattaattga tttacattta tcctaatggc ttttatatat
     6361 ttaaatctat ataatcttat aatacttttt aactatcatg ttcttcatct ataatcattt
     6421 cagtttcaag cccttctagc attgaatcta aactttcttt tatatttagt atataaattg
     6481 gtacatactc ttcttcatct attacctctt cttgcaactt aaatggagga attaatactt
     6541 catcaaagtc tatatttaaa tttggaaagc cttctactat ctcttcacaa ttatcgtact
     6601 cttcatttgc taaagaaatg tacatatcta ggctcttttt ataataaaga cctgcaagca
     6661 tatactcaca cttcttactt ccatatttaa taccttcttt ataatatttc tcagcttctg
     6721 cgtcatcatt taattttaaa taaatttgac ctaaattata tattgattca acacaacctt
     6781 gtgctctagc cttttcatac caaaatttag aatttacata atctttatag aacatatcat
     6841 aaattaatcc taccatatgt tgagcataca cattattttc attggcaggt gtatcaaaca
     6901 tcattttaga ctcttccaat ttaccttctc taaaataaat tctacctaga tgtatacgag
     6961 cattcatatg gtttttgcta cttgccattt caaaatactt tctagcattt tttgtatttc
     7021 ctaagctctc atatatacac cccaatctat aactagacct cgtatctcca ttttcagatg
     7081 ctttcttata ccaacttatt gcttcttcaa tattatttaa atcttcatag atatttccta
     7141 atttgatttg acaagataca ttatttggaa tcctcgaata atacgaaatc gctttttcta
     7201 tatcttgatt ctgataatat aaatccccta gattttcaag ggaacttttg catccaacag
     7261 ctatagcatc ctcataatat ttaatagcat tttcataatc tttttcttca aaatatatac
     7321 ctgccagatt attttttgct tctgttatat catcttcagc agccatttta taataagttt
     7381 ttgccttctc tatctcattt tctctattat ataaattagc aagtctatac ttagaaagtg
     7441 tatgattttt ttctattgct ttctcataat aataaattgc atctcccagc tcttcttttc
     7501 tatcatatac atatgcaagc ctatactcag acttcacatc atctctatca gcactctttt
     7561 tataatactt ctctgcatct tctaaattat catttatttc cataatcata cccaagttaa
     7621 agcaaccttt catatgacct gacttgtaca actgtttata taaacttact gttgatttat
     7681 tatctttctt ttttccattt aatattgcta aattatattt tgcatcatca tctaaaagca
     7741 cagaaccttt tttatagtat tcatatgctt catcatcttt ctccaaaaaa gtatataata
     7801 cccctaaatt aaaacaagct ttacctaaat tcttgtctgc tgctgttttt aaccattttt
     7861 cacaccttac aaaatctttc attttaaaat ggcatacacc taaattattt tgtgcttgta
     7921 aataacctaa atttgctatc ttttcatacc aatatatagc atattcatag ccatctaact
     7981 tatagtacat attacctaaa tcaaaagcag catcttcact tccactttta tatgccattg
     8041 aataccactt ttctgcttct ttaaattgtt ttttactttc atatatattt cctaaagtat
     8101 attgagattt tacgtaatta tccaatgcag cactcttata caactctatt gcgctttcca
     8161 tcttacccat cttttcaagg agggcaccct tagtatgtac gactttcggg tcattagata
     8221 tattttttat tttttttata gaaaattttg tatttttcat tattcgctac ctacccattt
     8281 tataaaatat attctctcaa acattattat acattataat ctacaattaa tgctataata
     8341 ttgaattttt accttttgtc actatattgt aacattaaat tttaaatttt ataatcatta
     8401 gattttatta tgtaattggt atataatgta tatatagggg ggacatttta tgaatttcag
     8461 caatattttt atccaagttg cagttttatt tataattatt ttagttggat attttgtcag
     8521 aaaattcaac ttattagatg accactgcac atctaagctt tcaactttga caatgacagt
     8581 ttttttacca tcaatgataa ttagctccat gcaaattaac tttgatagta aaatgataca
     8641 aaaaatacta ttgttattat ttacatcttt gattatgtat atagtttcaa ttataattgc
     8701 atttttattg aaatacattt taaaatgtaa tgataaaaaa gatttgggaa tataccagta
     8761 tatagttgtt ttttcaaatg ttgcttttat gggttatcct gtaattgaag cagttttagg
     8821 tcatgaagca atattctata ctgcaatatt caatttgcct tttaacttat tttctttcac
     8881 tttaggaatt tatcttttat ctaaaggcag tacaagtaga ggtttttcaa taaaatcact
     8941 tataagccct gctacaatag ctattgttat tggacttttt ttatttgtaa caggacttag
     9001 gttaccccaa tttataaacg agccacttga gatgttggga agtataacta caccaatatc
     9061 catgattatc attggaagct tacttgctaa ttcttcagct ctcgattgtt ttgtcaacaa
     9121 aaaattatat atagtcactt ttataagatt attggtactt cctgtgattg tgtattttat
     9181 tctaaaagga tggataaatg ataagatgat tttagctata ccagtagtaa tttcttcaat
     9241 gcctgctgct gcaaatactg ctataatggc taatcaatat gactccaata taacactagc
     9301 ttcacaatgt gtgtttttta caacactatt ttcagttata tctatacctt ttataagtat
     9361 tttactctta tcttgattta tttttttatg tattatataa taacatattc aataaattac
     9421 aaatataaac attttattgt agtatattga tggaattttt tcctagatat ttgtcaataa
     9481 tatctatatg tattatagaa taggaggctt aaatatggat atggatttac tctttaaaat
     9541 agtatttgct atagttgcta taggtgtttc tgtaaaaatc attaaaactg ttgctagttt
     9601 agcttttaaa atagcgttga tattgctaat aattttattt gtatatagaa tgtttttgta
     9661 aacatttaaa aataagtttt ttaacacaat agagaagtaa aatagattat ctttaatgta
     9721 aattttttat taaagacact ctattttact tctctattag cttatttaaa ttaaattttt
     9781 attatatctt cccataatat aaacatcttc aaattttcca tctctgatta cagcatattt
     9841 tttagttccc tctatttcaa aacctagctt tttatataaa tttaatccct tttcattatc
     9901 cacaattact tctaatccta ctctagttaa cataatccaa ttatctgcta tatctaaaag
     9961 ttgttccata agcttcttac ctactcctct tccctgataa ttctctgcaa cacttattcc
    10021 tatttctgcg ctatgtctca atcgtggaga agaatttaca tgtaacccag caaaacctat
    10081 tacatctttt tctccattat tattagtttc agctacaaac atataatcat tttctcccaa
    10141 agaagctaac atagcttcag ttttatcgac tctgtcactc attaatgcca aagtatttct
    10201 cataacactg tatgttcttc taatttcatt aaaagcttgt gcatcttctc ttcttatagg
    10261 tcttattgtt atatctatag gcttactcat attggattcc ccctcaaaca taatctttat
    10321 ttttaattaa aattttacat ctttatttta tactgttcaa atctatgtat gcttctacct
    10381 gaggtacata tatcatatta tcttttatat gtgtacttcc aaattctttt aattctgtac
    10441 cttctttatc cttagttatt ttatatctaa tggattccat accttcaact acttcagcat
    10501 gaaaaaacat accttcatat tgtttaaatc taaaattaaa attgtcttta gtaagtttta
    10561 ttatcatatt tttatctact ccttatataa ttgatatttt tcttattatt agttgtatat
    10621 atactgctta ttcatattaa tatattataa cttatcattt atttagtata aagttataaa
    10681 tagatatatt tatacttatt ttacaatctt tcttcaattg atatataata tgtttatata
    10741 aactaatgta tgtgaggtga aatatgagca aaaaaacaaa atatttttct ttaattctct
    10801 ttcctattgc tttgctttta aattttatag ccagcaaagt tccaaatatt gttgaaaaat
    10861 attactccca attcatagat aaaataattg tacaaatatt gagtaaagtt tctggaattt
    10921 tcccattttc tctctatgag attacaatgt acataatagt tatatctatc ttcttatttt
    10981 tatgttgtac tttatctaca atttttaata agaaaaaaaa attaaacata tatttaaaaa
    11041 attccatttt aaatatatta tccattgtat caatagtcta ctttcttttt gtagtgcttt
    11101 ggggaataaa ctataatagg attccactag aaaccacact tataaataac tataatttaa
    11161 aaaacaatac ctctatccaa tcaaaacaat atagtgttaa agagcttact aaattatata
    11221 aattccttgt aattaaagca aatgaaacta gaaaactcac attacaagat aaaaatggta
    11281 ttgtaaaatc taatacagat tataatggtg tcataaatag agctcaacta ggatacgata
    11341 atatcttgga tatattacct ggtgttagtg gtagttattc taagcctaag tatattattt
    11401 catcaaatct aatgtgctat acaggaataa ctggtatata ctttcctttt acaggtgagg
    11461 caaatgtaaa tatagcaata cctgacttat atattccttg tacagttgaa catgaaatgg
    11521 cacatcaaag gggatttgct agtgaagatg aggctaattt tatagcgtat cttacttcta
    11581 taaaacaccc caatattgat tttaactatt ctggatatat tttagcttta aattatactg
    11641 cttctgcttt aagtaaggtt gattataatg catatgttga tatttctgct ggcatttcag
    11701 attctgtccg tagagattta aaaaatgaaa gtgaattttg gcaaaaatat gaaggtaaaa
    11761 ttaatgaaat ttctaatgag tttaacaatt cttacttaaa agctaatagc gttactgaag
    11821 gtactcagag ttatggtaaa atggttgatt tattgctaac ttattatgaa ttatatccat
    11881 ataactaaac actacaattc aaaattttat tcatatacag ctgatattaa atcagctgtt
    11941 ttctatttaa ataaattatt taacttcaag caatcttata taatttgata gtacttatac
    12001 tatctgtata acatttcaat tctaactatt ttagttaaaa catttctatt atctttttta
    12061 ataaatgttt taactaaaat ttttaaaaca taaaacttcc acattatttc actatctata
    12121 taaaaatcta aaaattcaca tataaaatta cataactaaa aaatcataaa tttatagaaa
    12181 acatatattc aaaataaaaa agcatgtatc aaaacttgac acatgcttat aatcttatgt
    12241 atatatatca ttttgtcaca ataaaaattt acttgtaaca ctgatatttt taaacaaaat
    12301 agtccttatt taattaaatt aacattaatt aaattcgtac tcattttgct atcattaaac
    12361 attacttata gtaattttct aatacactat ttgaaacttc cttcccttga aaacttttca
    12421 accaattctc atatgctgag tttttccata cactaccatc attaaatgtt acttgtttta
    12481 cacaagatat aatgtacttt acaccatgct ctccagttga ttgtttccat ttatcaaaca
    12541 atagaaaggc atcattttga ttcttacctg gtgctattgc attttgcttt gcatattctt
    12601 tctccatttg tttccattct ttcaaccaat tttctaccca tgccttgcct tgttgttttt
    12661 caaacatact tattatatcc tgtggtggtg attgttgcat ttttctataa gtatgtgaat
    12721 atgattttgg aaacacagga gatatgcctg taacaatacc atagtctaca ccagctgggc
    12781 taaatccaac acttcctact tcgccatctg ctgccacatt ttgagcatcc caatatagct
    12841 caagtggttt tccattttta tcatatgcta agcatgtaat ttcataatcc ataattgcct
    12901 tttcactgct atttgttaag cttataacat tgctaggcca atgatatgga gtatcatcat
    12961 actgtatttt gctattattt ataaataatg gaatattctc attataaaca agacctttac
    13021 tactttgaat atctgatacc ttctttgtga cagtacttac cgtatttgct aagtatacat
    13081 ttgttttttc tgaattggtc gtactaagag aaaatgttgt tgtcgttcca gtaatcagca
    13141 aagcaacaac taaaataggt aagctagata tttttttata tctcacaatt cttcacctct
    13201 ttttctatta acttataata aaacaattta ccaaaacatt aaaatctatg ttaacataat
    13261 ttaccaactg ttctagtaac tatatcctat catagttact atcaagtttc aatactattg
    13321 atggaaattt tcactatatt aaatcttttt ttaattttat aaatttacaa tatgatttaa
    13381 ctcatacata tatagtcaaa ttagaatata agtttcttac atttaatgaa gtttataaaa
    13441 taaaaaatga ctagataatt aaatactgta aataaaaact tattacaaaa gtatttaaaa
    13501 atctagtcaa ttaatatata tatgaattgt atactataat ttttcaatct cttctagcaa
    13561 ctcatcaact aatttgttac catcaatcat tctaactatt tcaccctttt taaataaaag
    13621 accttcacct ttacccccag caatacctat atctgcctct ctggcttcac caggtccatt
    13681 tacagcacag cccataattg caacagtgat atttttttcc atactaccaa tcttttcttc
    13741 aacctcattt acaacactaa ttaagtctat attacatcta ccacatgtag ggcatgatat
    13801 aactttaatc ttatcattta aaagtcccaa acttcttaaa atctgtttac caacaataac
    13861 ctcttcaaca gggtcgcctg ttaaagatat tctaacagta tctccaattc ctttaagaag
    13921 aagtgctcct acccctatag aagactttat tgttcctttg tgaacacttc cagattctgt
    13981 aattccaata tgaagaggat aatcaacttt ttttgatatt aattcatatg catcaacagt
    14041 tttataaata tcggatgatt ttagagatat aactatatta tgaaaatcta agtcttcaag
    14101 aatcttaata tgtcccattg cactttcaac taatgcttca gcagttgcag agccatactt
    14161 ttttaaaagt tctttctcta aagaacctcc attaactcca attctaattt ttaaatttct
    14221 ttccttgcat ttctcaacta ccatcttaac tctctctata cttccaatat taccaggatt
    14281 tattcttatt ccatccacac cttgttctat agcttcaagg gctagcttat aatcgaaatg
    14341 tatatctgca ataattggta tatttacact agactttatc tttgctatat ttttagcagc
    14401 tttaatatca ggaacagcaa ctctaactat atcacaacca gcttcctcta atctctttat
    14461 ttgagctatt gtagcatctg catctcttgt atcagtattt gtcatagatt gtatacttat
    14521 aggattttct cctcctattt ttacagttcc tacacttact tctctcgtct ttcttctctc
    14581 gtaactcata ttccacctct atatattatt ttatattgaa tctctttaaa tattaaaata
    14641 ttataaccta catgtatatt ataaattaaa aagctatcta gttaaataag aataaatttc
    14701 atatataaaa attaatttat tcttatttaa aactacatag cctattttct taaaatctct
    14761 aaaaactaaa tcattgaaat aatcttagta tatctttata tgtgataaaa agcataaata
    14821 acattaaagc tccaaaacca acaacattta tcatgccttc tttatttggg tcgagttttt
    14881 taccacctct aacagcttct agtaacagca taagtattct ccatccatca agtgctggta
    14941 ttggtaatag atttactata cctaaattta agcttatgac agctgctaaa tacactacat
    15001 ttatgatgcc tgtacgagca gcatctgata ccataccaat aacacctact ggtcctgcta
    15061 cagcattgcc aatccctcct ggtacacgtc ctgtaatcat ttgacctaga aatgttagca
    15121 tctgttttgt catatctaca gtagttttac atgcatttac tattgacccc aaaaagtctt
    15181 tttctctttg tggttgaatc cctatttcat actttccatt gttattttta ggtgttacat
    15241 ttacaacttt atcacttcca tctctagtta tactaagttt taattctcca ccagaagaag
    15301 tatttattat atttgcaact tcatcccaag tcttaacaga attaccatta attttattta
    15361 tcttatctcc tacttgaagc cctacagcct gtgcaggagt atctggcatt atctttccta
    15421 atttagtcgt tggagaacct atatacaaaa atactggaac taaaagtatt gctgctaata
    15481 ttatattgaa tattggtcct gctacaatag tactaaatct ttgtaatata gacttgtttc
    15541 caaaagaatt tggacttatt tgttcttcat cttcaccttc catgctgaca tatccaccaa
    15601 ttggaagtgc tcttatagaa tactctgtat ctttttttac actatatatc ttaggcccca
    15661 tacctataga aaactcattt actttgatac cacttctttt tgcaaatata aaatgtccta
    15721 actcatgtat taatacaatt atactaaata gtattaatgc ggctattata gtcataaatt
    15781 caccttccta tttttttatc agatttgcaa cataagctct actccatcta tctgtttcta
    15841 agatttcttc taatgttggt tcacttatgc tactatgaac ttctaaagtc ttctctatgt
    15901 aatatggtat gtcatagaaa ccaattttat cctctaaaaa ttcacttact aaaacttcat
    15961 ttgctgaatt taaaacagag gaataagttc ctcccatttt taaacactca tatgccaatt
    16021 ttaaacatgg aaaagtttct aaatctggtt cttcaaaagt taaagtacta aattttgaaa
    16081 aattcattct ttcaaagcta ctttccattc tatctggata tgtaagagca tactgtattg
    16141 gtagtctcat atctggacat cctaattgag caattattga gctatctgta tactgcacca
    16201 ttgaatgaat tatgctttgt gggtgaacta ctacatctat attttcttgt tctactccaa
    16261 ataaccatct agcttctatc acttcaagtc ctttattcat aagcgttgaa gaatcaatac
    16321 ttatttttct tcccatactc caatttggat gcttcaaagc ttcattttta gttatatttg
    16381 caagttctcc ctttttcttt cctctaaatg gaccaccaga tgctgtaagt attatctttt
    16441 ctatattttt tttattttct ccatttagac attgaaatat agcactatgt tcactatcaa
    16501 caggaagaat atttacattg tatttttctg cttctttcat tacaagttca ccagcagtta
    16561 ccaacgtttc tttattcgct aatgctatgt ctattccctt ctttatagca caaagagttg
    16621 ggactaatcc tatcatacct actacagcag ttaaaaggac atccacttca tcaagtgatg
    16681 atattatttt taatccttcc attcctgcta aaacttctat ttctatattt ttaggcaaca
    16741 tttcttttaa tttcaatgct ttattttcct caaaaactgt tacatattta ggtttaaact
    16801 ctactatctg ttctagcaat aattcaatat tactgttagc tgatattgca actatctcaa
    16861 acttatctct attatctcta actacatcca aagtttgttt acctatagag cctgtagaac
    16921 ctaaaattga tatctttttc atataataat cctttctaat aataaatata ccctgtcaaa
    16981 acattataac actactaaaa caattatttt tactattcat agaaatttca tatattattc
    17041 cacagattaa aattaatcta ttattttttg tattttgtgg aatattataa aatattctag
    17101 tattattaaa tgctcttttt tatttccaca acatcttcta ttttacagtc tagtgctaaa
    17161 catatcttct ccattgtatc catagaaaca gatttatcat ttcctagtct gcctaaaaca
    17221 gaaatactta tacctgatat atttacaaat tccattttct ttatttttct gtcaattaac
    17281 aatttccata atggagcgta tgaaatcatg ttatcacctc gcaaaatata ttctatcaca
    17341 ttttatctat tttggaaaat tttcatctat ttagataaat aattatttat ctaaatagat
    17401 ttcaattata gtttattaaa tataaatatg ttaaaataaa acaaaagcat aagttcaaaa
    17461 attaaacttt atatatattt atctcattat tttactaaaa cataactata taaaaaatat
    17521 ttactattat atatctattt aaaacacatt attatagtat catataaaca tatgtaaata
    17581 tataattaaa aaagctaaag attagtaaat ttataaaaat tatattttga ataaaaggag
    17641 aaagaatgtt gtatttatta aaaattaatc aatttgaaaa aagttatgat ataggaattt
    17701 ttaaaaatga acaatcaata tataaattta ttgcaaaaat accctttgta aaaaaagata
    17761 atagtaattt taattataca aattactata tggaatttga agatattcct gaatattatg
    17821 aagtaaattt caataattat ttatatatta ttaccaggtt ttcattcatt ccagatggaa
    17881 ctgagatatt ttttacttgg gaagaaatcc attgttggga tgaaaaagtt gctaccgaga
    17941 aaacttttat aaatggcgaa acattagtgg attcatataa ctttccaaat aatgaagtga
    18001 aagactacat acaaaagcga gaatcattat atatagaaac aaaaaaatat tatgaagaaa
    18061 aaggattaaa aattgagaga catgcactcg gttcagaaga tggtgaatat gttgaactta
    18121 caaatgattc tatactttat ttactagata tagaagcagt tgaaataaga gaacaatcaa
    18181 aaaatataga agaatttcta tataagtata aaaaacgttt taaataattt atattttaaa
    18241 atacataaca gtacattgag tcatttaacg agatataaaa tgactcaatg tatagactga
    18301 taaaaataat tatattattt tttagttaca tatttgttaa aaaattcttt ttcttctatc
    18361 ggtttagaaa aataaaaccc ttgtcctaca tcacatttaa ctgtatttaa aaattccaag
    18421 tcttttttag tttcaatacc ttcacataca acagacatgc ctatacgatg tgacatttca
    18481 ataatacatt gaataatact atatactttc tcccggttaa aggtttcttt aagtaagctt
    18541 ttatctaact tcaatccatt aatagataga gaacataaaa gacttaatga agagtatcct
    18601 gaaccaaaat catccattga aattaaaaat cctaactttt taagttcctc taaaattgaa
    18661 ataactggtt gagatatttc attaaaagca ctttcagtta cctctatctc tatatactta
    18721 aaaggaattt catattcttt aacagtatct aaaaaccttt gataaaaact attttggtaa
    18781 atagtaaccc ttgaaaaatt aactgcaatc ggatatgtat attgattttt tttcataaac
    18841 gtttttctta caaatgaaca cgcttttttt aacatataaa agtccaattc aataataaat
    18901 ccactttttt caaacaatgg aataaattca tctggtgata aaaaaccaag ttctggagaa
    18961 aaccatctta caagagcttc tgcgcttaca acatttaaag aagatatttg aaatttaggt
    19021 tgcaaataca tatgaaattc ttcattttct atcgctttat acatataatt ataaatacta
    19081 ttttccattt gtaactgttt taacagattt tcattatacc atactgtgga ggaaattcct
    19141 cttgttttac ttaccttgtg tgcaatattt gccttatcca ttatagaatt gatggattta
    19201 taacctaaat tatcaatttc aactaagtac gctcctatac aataagatat agtttgagtt
    19261 acattcatat ctaattcaga gattatagca ttagttagca tttcccgaat atcctctaaa
    19321 agagaatctc tatattttgc aagtattaca aaattatctg aaccaattct tgcacaagtt
    19381 tctttgatat taaaagtttt agaaagtgca gctgcaacta ttattagaac tttatctcca
    19441 tattcatatc catgtgtatc attaatatat ttaaaattgt caatatcaat atttagcagt
    19501 acatactctt tgttagatgc attgtgcaaa atttcaatcg ctctgttttc aaatgcaacc
    19561 tgatttttta tttttgttaa attatcagta taaaatattc ttttaaacct ttttttatta
    19621 taatattccc aaattaaaag acttattgtt gagaatataa gataaataaa tagtgcagta
    19681 gcaaaagaat acaattttgc attagagtgt ttttcagata taaaaacaat ttgattagac
    19741 aacacagaat actcttcact caatttatat aatttatcac ctgaagcacc atttctaact
    19801 tttataattt ctttcttcat agattcccac atagaatcca tttgatttag tttttgttga
    19861 aattctttat tatcacatct ttgaaatcca ttttctccat tacctgttct tagctttatc
    19921 agaatattat ccagtcgttt tatcaagtca tcatttcttt cattattcaa ttcttgctta
    19981 acaacctttt gagtttcact gcgaatagta ccagtgtgac ttataatttt aatatgctct
    20041 atactgtgat atagagaaaa tataaaaaga ataataataa ctagccaaat agcagaataa
    20101 attaaaaaat catatttttt cttcattatt gttacctcat ttgtaatata tataatttgc
    20161 aaataatcaa tctcttataa aaaatgatta tcaatatttt acagtgatat gtatttatct
    20221 taaatagttt aatcatttat atcctataaa ttatacaaat tcatcacctc caacacaaac
    20281 agcaatatac gtttttctaa aatttctttt taaacattca tcaacactat cattaaatca
    20341 tttttaaatt gctcaattaa tttactgcat cacttctttt cttataaaat atcaccccaa
    20401 taatatattt gtataatgtc tttatgtctc tttttaaatt tggcatatac ataatctata
    20461 ttttaataaa taattaaaat actatttacc tacaatttaa ctctttgaat ttattttatc
    20521 atattatgta aatatattcc ttttttttgg tatattactt aaattatatc tatttttgtg
    20581 taataagacc aataatttac ttatttctta ttaattatat ttaaaaataa aatttataaa
    20641 tggataataa attagttaca tttatacata tatattataa atatataata tagctaaaaa
    20701 tatcgaaatt attaaacaaa aaaatatttt ttaatgatag ttatagtata aaaaatatac
    20761 tcactacaaa tatagtatac tattataaag taatacctat tcttatacaa ttccccaagg
    20821 tcttctaaat ttttgaacaa tgaaaatagc catgtaacta ataactgcag aatatctctg
    20881 catttaaaag ttacatagct attttcatta ctagcaatta tagattgctc ttttaaatcc
    20941 aaccaatctt tatctaataa aaaatttaat cgcactatat acaaaaggtg caactaatat
    21001 aacactatca aatctatcta atataccccc atgaccaggt attatctttc cataatcctt
    21061 tatccctaca tatctcttta tagaagatgc aaataaatct cctaattgag ctattacact
    21121 tcctatactt cctattatcg ctaattgaag caaatcaatg ccaaataaat atccaaataa
    21181 aatacaacaa agtgtacttc ctattattcc tccaatagct ccttctatag tctttttagg
    21241 actaacttta ggaattagct tatgttttcc aagtaaataa ccactaaaat atgcaaatat
    21301 atctgtcata aaagatatca caaatataag ccatacatat atactacctt tttcaaatcc
    21361 atttatagtt ataattataa aatctaaaaa tactcctata taaaaaactc ctaaaaacgt
    21421 aatcgaaaca tctataacat tgtttttgcc catcaacata taaattatac ttgctaaaaa
    21481 taaaataaaa attactgcat aagtatattc taatggtaaa ttaaaaatat tttttacagc
    21541 taaataaata gaaaataaat atcctataat gaatattgga tgtacatctt ttattttaaa
    21601 tgccttataa aactcatgca atgcaatata aactattgct gtctcagcta tatatagagg
    21661 aatacctcca tatacaacaa atagaaataa tggaaccaga gctagtgaag caataattct
    21721 tgtaagcata aaataatctc cttacttaag tcctccaaat cttctatccc ttctttgata
    21781 tacgtatata gccttctgta gttcttcttt tttaaaatca ggccaatgta tatcagtaaa
    21841 gtaaaactca gaataagcaa cttcccaaag taaaaagtta ctcaatcttt gttcaccact
    21901 tgttcttatt accaagtctg gatctggtat agactttgtg cttaaatagt tttttataat
    21961 atcttcatca atattgttta tatctatttt accactttca caatttttta ctatatctat
    22021 aagagcattt tttatatctg ctctacttcc gtagtttaat gctaaattta agttaactcc
    22081 tgtattgttt tttgtcagtt ccttagctga gtttaattct cttatacaag tttttggtaa
    22141 agcacttata tctcctatag cagttacttt tacattgttt tggtgaagtt cagctatttc
    22201 atttcttaag tatgtagata ataagttcat aagtgtgtca acttcaagtt tcggtctttt
    22261 ccagttttct gttgaaaatg catataatgt taagtgctta acacctaatt ttgagcattc
    22321 ttttactata tctcttatag tttctactcc agccttatgt cctgcagttc ttggaagaaa
    22381 tctagctttt gcccatcttc catttccatc cattataata gcaatatgag taggtatgtt
    22441 atttaagtct atatcatata taatgttgtt attcatattt tgcctccaat attgttctga
    22501 ctccttaaac taaggagtca gaaaagtatg tgattatcag ttctacacta tcacctatct
    22561 cagatatttt tataactcta ggaactacaa gtttttcttt atccttttta ccttcaatag
    22621 attttacggt ataatttata ttttgctcat caaaatattg ttttacctca tctacatgaa
    22681 gacctaaaag gttataatat tttttcaata ttatacctcc attatgtcct tttctttttt
    22741 agataataat gtatctattt cttttataaa tttatcagtc attttttgaa cttcatcttg
    22801 tgcttttttt aattcatctt cagttaattc tccgcctttt tccatctttt taattttctc
    22861 attggcgtct cttctttcat ttcttattct aactttaaat tcttctgcag ctttactagc
    22921 ttttttagct aattcttttc ttctttcttc tgttaaagca ggtacagaaa gtcttataac
    22981 ctcaccatca tttgatggat ttaatcctaa gtctgagtta gctatcgctt tttctatttc
    23041 atgcatagca gatttatccc aaggagatat cattaatatt cttggttctg gtacagatat
    23101 agcacctatt tgatttattg gagttggagt tccataataa tcaactctta ttttgtctag
    23161 catttgtgca ttagctcttc ctgctcttat agttccaaat tcaaacttta aagcatcaat
    23221 tgtcccattc attttctctt ctaattgctt atgtatttcc agtttcataa ttttactcct
    23281 ccttcattct tcattatttt acagtagttc ctatattttc gccttttact gctcttatta
    23341 tattctctgt tgtaagctca aataccttta ttggaatttt attatccata cataaagatg
    23401 tagctgtaga atccattact tttaattctt tctgtataac ttccatgtaa cttaattctg
    23461 taaatttctt agcatctgca tgtacttttg gatccttgtc atatactgca tcaacatttt
    23521 tagctaacaa tataacttct gcttccatct cagcagcacg taaagcagca gttgtatctg
    23581 ttgtaaagta agggtttcct gttcctgcac caaatataac aactctttcc ttttctaagt
    23641 gtctaactgc tcttcttctt atatatggtt ctgcaatttg tctcatgtct atagcagttt
    23701 gaactcttgt agcaacatct atattttcta gtgcatcctg tagcgccatt gcattcataa
    23761 ctgtagctaa cattcctata tagtcagcag tagttctgtc cattccttca ctggttctgc
    23821 ctctccagaa gtttcctcca cctactacta cagctacttc aacacctatt tcttgtattt
    23881 tttttatagc aatagcaata tcattaacta catcattatt tataccaaaa cctctttctc
    23941 ctgctaatgc ttctccactt aattttaaca ataccctttt gtacattggt ttatccatca
    24001 gaaacctcct atttcaatcc ttcatatcca attttttcta ttttttaaaa aagagaacac
    24061 ctgcgtgttc tctctttggt tattacttaa gttgcttagc aacttcttct gcaaagtttt
    24121 cttctctctt ttgtatacct tcaccaactt cgaatctcac aactttaaca acttttatat
    24181 cagaacctac tgccttagca acatcagcaa ctaattgttt aacagttata tctggatttt
    24241 taacgaaagt ttgctctaat aaacaaacct cttttaattc tttttctaat cttcctttaa
    24301 ccattttttc aactatatta gctggttttc cttcatttaa agcttgttga gttaatactt
    24361 ctgtttcatg tgctatgtat tcagcatcta cttcatctct tgaaacatac ttaggattca
    24421 tagcagcaac ttgcatagct acatctttac ctaattctaa aactttagca tctctagctt
    24481 ctgtttccat ttcaacaaga acacctattt ttccaccacc gtgaatgtat ccagcaactt
    24541 gtccattagt tacaacttta gcaaatcttc taaagtctaa tttctcacct atttttgcaa
    24601 ctctattatt taaaacttct tgtaaagtta ttccttcttt atgagtttca cctaataaag
    24661 aagctatatc ttctttatca gtagctaatg ccatacaagc agcatcttta acgaacactt
    24721 tgaagtcttc gtttttagca acgaaatctg tctctgagtt aacttctacc atagaagcaa
    24781 ctgtattatc atcattcatt tctattgcaa ctagaccttc agcagcaact ctaccagctt
    24841 ttttagcagc ttttgataat cctttttctc ttaataaatc tactgctttt tccatgtttc
    24901 cttcagcttc ttgtaaagct ttcttgcagt ccatcattcc tgcgcctgta ctttctctta
    24961 actcttttac catttgagca gttatattag ccatttttta agtttcctcc tacttattct
    25021 attccatatt ataaatggta agggcgaccc ttaccattta attgtcaaat tattattctt
    25081 ggtcttcagc tacttcttcc tcagcacctt gtctaccttc aattacagct gttgccatag
    25141 caccagttat taattttacg gctcttatag cgtcatcatt tcctggtata gcaaagtcta
    25201 attgttctgg gtcacagtta gtatcaacta taccaactac tggtatacct aatctatgag
    25261 cttcttgaat agctatgttt tcttttcttg ggtcaactac gaacattgca cctggtaatt
    25321 caggcatgtc ttttattcca cctaagtatt tttctagttt ttctttttca gctcttaatt
    25381 ttataacttc ttttttagga agaacattaa atacgccttc ttcttccatt ttttctaatt
    25441 ctcttaattt atttattctt gtttttatag ttttgtggtt tgttaacatt ccacctaacc
    25501 atctttcatt aacaaagtac attccacatc tttcagcttc atcttttatc gcatcttgag
    25561 cttgtttttt agttcctacg aataagattg gctttcctgt ttcagctact tctttagtga
    25621 acttgtaagc ttcttcaact tttttaactg ttttttgtaa gtcgattata tatattccat
    25681 ttctctctgt gaatatatac ttagccattt tagggttcca tcttcttgtt tggtgaccaa
    25741 agtgaacacc tgcttctaat aattgtttca ttgatattac tgacatatct tacctcctgg
    25801 ttttatacct ccagcttgat cttctcccta aaaaaccatg taataggcac cttttaagga
    25861 tcccaatgct gtgtgtgatt tattttattt tttcacctct agtagtatat cacagaggtg
    25921 aagaaataac aatatttttt ccatattttc tatttttata tttttttgtg tattttatac
    25981 cattttttga atttaatttg caaatttcat ttttaatttt gtttttaatg atacgttatc
    26041 tatactatta ttacttacta tatctacact tccaagtaag tcacctgaat tagtataata
    26101 ttttataata cccatagtat cacctttttt aacagggtac tctatatttt taatcttaac
    26161 ttctgacttt atactttcat catcttttaa tattgtataa agttcatctt ttgcttttaa
    26221 tgtaacctct aactctttcg ttccttttat atatttctta ccaataaagc tatctttatc
    26281 aattactttt ttcatattga aattttcttt tccatatttc agtagagcta atgaagcaga
    26341 ggttctttta tttttatggt tagtacctaa tacaacccct attactctac gttttttctc
    26401 atttttatca tttttattta caaccataga aaatgataag caatatccag cattgccagt
    26461 atatccagtt tttataccat ctacttctgg tataattctt aataatgcat ttgtattgct
    26521 tttttcaaaa cttctatctg aatttgtata tgtctccata tcagttatag ctgttacttg
    26581 tttttcataa tggtcaaaca tgtattttcc aagaatagct atatcttttg cagtagagat
    26641 attttctttt gctggttttt tggggttgct taaatcgtat attggaagac catttggatt
    26701 tagaaaatgt gtattactca ttcctatttc ttttgctttt ttattcattc tatctacaaa
    26761 tgcttctttc gttttacaaa catgttttgc tatagcaatt gccgcatcat ttcctgatac
    26821 aatcataaga cctctcataa gctctataag tggcacttct tcaccatctt taagtttata
    26881 acttgaccct tttactgatg caatagattt gtctattttt accttatcag tttcttttac
    26941 ttctttattt tcaatagctt ctattgcaag taaaaaagtc atcatcttac ttaaactagc
    27001 taatggtacc ttcatatcag gttctttact atataaaact ctacctgttt cttggtctat
    27061 aagtatagat gtttttgaat acttgtctac agatttatca tctgcatatg aataatttgg
    27121 tattataaaa actagaatca tggctaatga tataattttt tttagtgcat ttttcaaatt
    27181 tttcaccttc ttggattatt aagtatattt atatttaaat tttccctatt tagtccaatt
    27241 tatatctagt aattaatacc tatccatatt tacacaaata ttaccttatc attcttttaa
    27301 taatcacaga tgcccaaatt gctcctattg taactccaaa aaatacttct atacctgcca
    27361 atgctttccc aatcaaactt gtagcaacca tatctccata tcctactgta ctaaatgtag
    27421 ccatgctaaa ataccataaa tccatataca ttttgaaaat ctcacttagt gagtaatcac
    27481 ctatattatt tatatctaaa gctacaagtg tgctatttga actttctatg cctacaaata
    27541 agtataataa agcaaaaaca cttattattg ctataataac taataatata ttccatggct
    27601 tttctccata acctgttgtg taacgtgcta tttggtcaaa aaatttttca actaaataat
    27661 cactgaaggt aggataatta gaacgtttca ttattttact actataaatt ctttccttat
    27721 aatagtaaaa tcctatcatc tcatattctc caatttttgt tgcttgattt ctagctattc
    27781 tataatttat cttgccatgc tcatactcac tttttccata ttcaacattc tttaacacaa
    27841 attttgtaca catgctaaaa attattccat ccattcgtgg aaaattttct actttattaa
    27901 ctaccaaatc aggtccttta aatttcactt tttcaaatat acggtcattt atatagtgtt
    27961 tactaaatat ggttctatta aaatcacagt tttctaagaa tacacaacca ttaaataaaa
    28021 ctttatctct aaattctgta tagttaaaaa taatattctt tttaaaaata tattttttaa
    28081 aatttgcttt ttgtttaaat atggattcag aaaaatccag tattttataa ttgtaagtta
    28141 atatttcttc cgcattaaat tcattttcaa aaacaaatcc attaaattca cttatctctt
    28201 ctttatgaag agtatccatc atcaattgta tctcttcatc agacttattt tctttatgaa
    28261 agatacaata tccagaagaa tctgcttctc tatgacattt ttttctctca tctattttag
    28321 atatccattt acaattcata aatatatatc ctccagtaca aaacaattat tactattttg
    28381 tattagtttg gatattattt tattttatat acttaaatag ttacaaaata tatattagat
    28441 tcttagtttt aaatttttaa tctacttcat tgtgctttta atttgtttca tataaaaaat
    28501 aataaatttt atatactttg atttatttat atattaaata tgattctaaa acttacttat
    28561 catttttaag taattttgta actatattta atgctactaa atcatccata aatcctattg
    28621 ggaacacgaa gtctggaatc acatctgttg atataacaaa gtaaagtagc atacttccaa
    28681 tcaataaata tttctttatt gtaagtccat ctgtacaaaa atcagcatac atttgtctta
    28741 atctatctgt aaattgacct tgtttttcaa tagaatctat ttttttatta aaattatcaa
    28801 aaagtaattt tttaccttca tctgtttgga catataactt acacttactt aactcttttt
    28861 caatatttcc attaaagttc ttatcattga ttaaatttgc aaatccaaga atatcatcaa
    28921 agttactaaa atcactatct gcattaaata tttgattatt gctgtttcta aattcatatc
    28981 ctgaagcttt caacagttct tctaggttaa tatttaaatg tattgccatc ttttctaaat
    29041 gatttatatt tggcttttgt ttattattag ctatacgaga tatagtagat ttatcaattc
    29101 cacttttttt acttagttct cccattgata attctttttc atctaataaa actttcaaca
    29161 aatcaccgaa attcccaacc ttactatgtt gttccattat tttcacctgc tttattatga
    29221 ttggttttat attattatat gatatgattc ttttgttatt taggtgttgt atgatgttgg
    29281 aattttatca acaatttatt ggattatctg taacaattta tccattttta caatactata
    29341 actaatataa gtacaaaatt taagagaaag gatgttaatc tactgtgatt gaatcaattt
    29401 tattagttac ttctctttgt atagatgcct ttgtgacaag ctttggatat ggcgtaaata
    29461 aagttaaagt tcccttatat tcaaatataa ttatcagcgt agtttgttca gctattttag
    29521 caatatcgct ttttgcaggt acaatagtta gagacttttt acctcaaaat ataacaatgt
    29581 taatatgttt ctttatttta tttttattag gaagtgctag actaattgaa agttttttta
    29641 aatcttattt taagaaaaaa tctatacact caaagaatta taattttaat atgttagacc
    29701 ttaaattaaa ttttaatgta agtattgaac ctgatgtctt agatacaagt aaatctaaag
    29761 tgcttaaatc tgctgaagca tttacacttg cacttgcttt aagtttagat ggattagcta
    29821 tcggttttgg tagtggcctt gtaggtgtga attatataca agttattcta ttttctttaa
    29881 tatcaaatat aattgcagta ttacttggtt gtttactagg aaatatgttt gttaaaaacg
    29941 taaatttaaa cttatcttgg ttaagtggtt taatcttgtt agtcattgga tttatgaaga
    30001 tatgttaata agaaagcaat ctaaagataa acttttctct ttagattgct ttcttttgtg
    30061 ctttttatat ttattttcta ttctctctaa tttctttctg aatcttttta agagcttttt
    30121 ttgaacctct ttgaatatct ttttctaatt ttctttcttt aaaactagta aataatacat
    30181 ctaaatcata cccttctgga tacaattctg atgcttttat gctaagttgt aatcttttta
    30241 tatttactga aataaaatta tcattaaaca atacttctac attattaaac ttgtccatag
    30301 gcttatatac aattccaaaa tcatcttcat ctagtaattt taccttatcc cctacattat
    30361 aatctgtata gtttaaaatg acttcagaac tatttttatc ttcaatatta gattgtagct
    30421 tacttctttt aactaaatct aaattgtagt ttctatcaat tacatattct ttagctctat
    30481 ctaaaactct attttttatt cccatttttt tagaaataaa aagagcatta ctatcttcag
    30541 attttccaat agttaactta tacaatggtt ctaacgtttc tttatcaaac atcataccag
    30601 cattttcaaa ttctggatgc aatgtagcaa acttttttat ctctccataa tgagttgatg
    30661 ctatagttat acatcccatt ttgtaaaact cttctaataa tgatattgct aaaccagctc
    30721 cttcattagg ttcagttcca cttcctattt catcaaacag aacaagagta gaattatttg
    30781 ataaactcat aatctctgca atatttttta tatgtgatga aaaagtactt aaggcatttt
    30841 caatactttg attatcccct atatctacaa aaactttttc aaatacacta aattcactac
    30901 cttcttttgc agaaatatca aatccacatt gaaccattaa agttagtaaa ccaacagtct
    30961 taagggttac agtttttcct cctgcattag gacctgttat tataagactt ctataatttt
    31021 tgcctatttc aaaatctaaa ggtactgcat ctcctgttag aagtggatgt ttacctttaa
    31081 ttatttttat atagccatta ttatttattt ttggagtaat tccttttatt ttttgactat
    31141 acttagcttt tgcaaatacc atatcgtatt ctgaaagtat ctctatattt aattttatct
    31201 gacttatctt ctcaaatata agttctgtta aataagataa tattttgtat tcttcaatag
    31261 tttcatcagc ttttaacata gttaactctg tacttaaatt tgaaacacta ataggttcaa
    31321 taaataccgt atttcctttt gatgatgtat ctaatatagt accattaact tcatttttat
    31381 aagaagattt aattggtatt acatatctat catttctttt acttattata aactcttgta
    31441 tatacttttt atttacagtt gatgttataa atttatttaa tctatctttt atctttcctt
    31501 ctgtaatttc tatatttcgt cttatctttt ttaattcttt actagcatta gaatcaactt
    31561 tattagattt tatacagtaa tttatctcat cttctatact tttacattct gttatattta
    31621 aggcataaga acttaatgta ggtgaataaa attctttttc taacataaaa gctttcatct
    31681 tcctacaacc tcttaaaaaa tcttcaatat ttacaagttc aacaggttct attatcattc
    31741 ctttttcaat tttatctatt gtagaacctg cattaaacaa tccttcaagt ggtatgtgat
    31801 tactattttc aattatcttt ctagcttctt tattttctgc taatttcctt cttactactc
    31861 caatattccc actaggagtt aatttatcta ttaaattttt tcctagtgaa cttacacaat
    31921 gtatttttat taattcttta acttcattta gttgtaatct ttcaaatgta ttactattca
    31981 ttattttttc tcctttattt ataagttatc gtcttttaaa tcaccctatc atttactttg
    32041 ataatagtta ttttgcgaac aacttaataa ataaggagtt attatatatc aaactcctta
    32101 tttattaaga agtttaactc cggactcatt aatgttagta ttttttttca taaaacactt
    32161 ctccttttct attcttattt aaacacttat atcagtgctt ctaatattat tccataaatt
    32221 atatatttat gtcaataaaa ataatgtcat taatgttttt gtacagtgaa aatttttata
    32281 gtgaaaataa gcttatactt tcatttatat ttgggaatca cttatattgt catcaattca
    32341 tgtatgtgca ttttccaata cagtctaact ttgtaatcat tatatatcaa agaatttagc
    32401 tctataaatt atcgtctcta caaaataaaa aaatagctaa taataaaaca cttttaaatg
    32461 ttccataaaa ttagctattt ataatataat tttaatcttt tttaacttta aaaattatcc
    32521 tttataagta atcaatggct tcatagttgc cactacttga ataagttcat attctatcaa
    32581 actttcaata atctgctcta tattcttata tgcctctgga gcttcttgaa ataataaatt
    32641 tacatcatta catataatct gacttttaaa tttagtttgt tttatagtat ctttattata
    32701 cttactttta aggcgagatt tacaaactga acgagaccat tttctacctg ctccatgtga
    32761 tagagaatat aaagatatct ctgtattttc agtaggcata actatatatg atagactgcc
    32821 tcttgaacct ggtataatca cagctcctct ttcacttgaa acagcacctt ttctatgtat
    32881 aaatttatct tcccttttct ctataaaatt atgatttata gagaatattg tttcaacatc
    32941 tccagatgta cctattgact gcataatttt tttactgata gcttcacgat tacgctctgc
    33001 ccacattaaa gcattatcat gttttttaat ataatctata gctttctcac tttcaacttc
    33061 aagtccatct ttatcataaa atttttttaa aatatcttct ccataatttc ttgacccaca
    33121 gtgaactaac atcataatat catcagatga aaattttaat tgttcaaatt gttctttatt
    33181 ataaatttca cttatacatt gaatttctac aaaatgattt ccactcccta tagttcctaa
    33241 atttaaaatt ggacattctt ctttatatgt gttttttatt tctatatcgg acaaatcttt
    33301 aatcttacta agtgacttaa tccatttgtc ttttttaaat ttctttttta gaaccccagt
    33361 tttaaataaa gtcattccgc atcctatatc atttccaatt atatgtggat aaataatatt
    33421 tttagtctca actgctaaac ctacaggtat tttacctgca tgtaagtcag gtaatcctac
    33481 tactcttaaa attccattta actttgaaat atcttcaagt tgtttccttg ctatatcttc
    33541 aatccaacat ttattacttg ctattatttt tatattgctc ataatttgct cctttttaat
    33601 attctcctgc ctttaaaaag tagcaaaaag ctgtgacctt tagccacagc ttttttattc
    33661 taaactgtaa aagcaggtgg ctatttgtta aaatactcct agacgtttaa tacctcatta
    33721 ttttttgtta acataataac cacttccttt cataatttaa gactacacta aaatttctat
    33781 gtatatcctt tatagacatt gattttaaaa tacttaatat acaattttta tattatggaa
    33841 ctaataataa tcattgaaat catgactata gctagaccgg caacaacaag ttttttatgt
    33901 aatttttttc tcattttact tttatattct tttttaactt gtataacttt gtcttgtttc
    33961 tgctcttctt ctttctcatc ttcaacttct atatatgctt tttcatacat tactttactt
    34021 aaatcaataa taatatcatt ggctctagta tacttattat ttcttccaag aagccttttt
    34081 ataacattta taagttcagt atttccatta attgctttta tactattcca atctaatccc
    34141 ttatcaatag attgtagcat tttttcttct gaatttgatt ctccaaaagg caatttttta
    34201 aatatagatt caaatagaat aagacctgtt gcaaaaaaat cactttcttt atcagtataa
    34261 tttatacata gttgatgtgg gcataaatat ctcctgtttc catagcttct tgtattaacc
    34321 ccattatttg cttttgtaat tccaaaatca caaattttta tattgtattc tgtatctact
    34381 attatactac tcgattttaa actaccatga tatgaatgat tcctatgtat catttctaaa
    34441 gcttttaaaa cttgtatcat tatgtttaca attgcttcta aatgaagata attacctaga
    34501 attaattcat ctagtccgat accattaaag tcttcactta caacataata taatgttgtt
    34561 tcttctgtac agtgaatccc aacatctatt atttttagta tataaggaga gtttatctca
    34621 tctaaagcag tactttcatc aattaaattt gaaacaaaat cttcacagat ataattattg
    34681 tgctttataa cttttattaa cacatttttc ctgtaaaaaa catctctagc tttatagatt
    34741 ttgttaattt ctaaaacgtc atcagaattt actacctcat atctattgcc tataaaattc
    34801 aaccatgtca cctcctcata cattttatat aactaaatct atttacaatt ataccaatat
    34861 ataggaatat tttctatata ttaatgattg taatattaaa acaagaacta atagtgttaa
    34921 tttttacaaa aaaggctgtc tcaaaataga gatacgcttc ttttgtattg ttgaaatgat
    34981 gaaaatatat ttgatttcac agaaaaagag tgcctcataa actaaaaagt tcattttgag
    35041 acactccctt ttatattaca aatatttctc taaaaaatta tctatttttt taattcttta
    35101 taagaactat ttgatatatg ttcttttttt atgacctttc cacttgaatc tttaaatatt
    35161 cgatatgtag aatatttatt ctgaccagtt tgttttacct ctatagatat atttggtttg
    35221 tcaccagaat taccatagat tactgatgat acacttcctc cacctgcata atttttaata
    35281 tatacaggat gcttatatgg atttttaaac tttaagttta atcctccatc gctcacagta
    35341 gcatctctcc ctttaggcac ataagtagat gcagatgaat gatttgtaac ttgagttatc
    35401 tccatacccg aaagaagagc agcattataa actgttgaag atgtttgaca aacacctcct
    35461 cctgctgatt gttctagctt accataaact ataacaggtg catctttgta accatttgct
    35521 ttattactag gtcctgtaag tttattgtat gaaaattctt cacctggcat taataataca
    35581 tcactagttt ttcttgctga taatcctaca ttatatgacc taccctctac agcttgtgaa
    35641 taagtagttg aatattgacc tataacagaa tttacagttt ttacttgttc agttgttata
    35701 tctggttttt gaagatttac tttaagttct aaagttttat gctctttatt ttttatcata
    35761 ttatatatag actctttatt tgctgccaaa tcaaattctc tacctacaac agagtctgta
    35821 taacttagtc caccacttcc aacactaata gaagcatttt tcatcttaac atttatacta
    35881 tctgctatag aagacacttt ggaactaagt tttgcctcat catattcagc ttttatcttc
    35941 atatttgcct tattcactct tatatcaata tattttttta agttttgaaa ataggaccct
    36001 ttttttgtac tttcataagc atcttttaca acatcttctg tatcatattt taaatcaata
    36061 tcttttggtg atattgtata ttttttccca tcataagcaa gatttaagtc ttctggagta
    36121 tacttatctg ttatagcttt taatgcctct gctttagtca tatcagatac atttactcct
    36181 tctatatata catttttagc gattttccca ttgtacagaa atttactgtt aaaaaaataa
    36241 gtaaatccac ccattattag aactaaagct gccaatacaa ttaaaacact tcgttttttt
    36301 tctttaccta atcttgaaac tcttgttgtt cttctgccca taacttcacc tcattttaac
    36361 actagcttaa atttgcataa tagagttccc atttcaaaac taccttagat tatatttgaa
    36421 tagcttttgt taaacaagga atttaatcaa atgtaacttt attgtaaatt tatgtcttat
    36481 aattagtttt atttttgata ttttttatta tatttctttt actatttctt aacaaaaaaa
    36541 ttgtttattt tataacaact aatttcattt atattgaaat ttaaatgtaa cctattacag
    36601 gataatggtc tgacaggtaa attttttcta ctgtgtatcc ttttagttca gtatttttat
    36661 taacaaaaat gtaatctatt ctagagtttg atttttcaaa tgttggtaag taagacttgt
    36721 ttagtgaaat agccatatca ttaaacatac ttaaaaagac atttttctca ttaaaatcac
    36781 cacataaaat aactatcccc actaatctgt tcctatagtc tattatttcg tctaattgtt
    36841 ttgctctctc ctgcctatca agtcccaagt gagtatttat tacatttata attcttccat
    36901 atgcatctat agttatacaa agagctcccc gttgttcttt tttgctagtt aagaaaaaat
    36961 gattactgtt taacatttta gatgttgtaa atgtacaaat accatatatc atatttactt
    37021 tttttacatt tgtagcaaag acaccaccca tatttaaaac agcttttaaa gctaaaaatt
    37081 gaggatataa tacttcttgc aaacaaatta catcacaatc caattgtttt aaatataacc
    37141 ccattttagt tagagttaat ctattatttg aatccatacc tttatgaata ttgtaggtta
    37201 ctattttcat aataatatca cctcttatgc aatataatac ttactaaaat ttaaacttat
    37261 ttacttttca cttaaaacca ttatttatct tataaaattg agtacttata aactttatca
    37321 caaaaaaacc taacttaagt atttatattc tacataagtt aggttttata aactattata
    37381 atatttatta tttcattcat ttctaatgat gattctcctt ttttatcttt ttcaatttgc
    37441 cttcactaac aacaaataaa aatcccatct tcttgtatat ttcatccaat tcaattaaag
    37501 ttacttcacc attttttaaa tttgttaatg ttatatcttg tattcttctt gatggaatta
    37561 tcataagtta tcaacactcc tttaaattct ttttaatctt tatatttaaa tatatttatg
    37621 cattctgata tatattcata aattattaaa ataaattcaa aaaacacccg ttccgcaaac
    37681 attcgttctg tatatttatt atacatcata cagacgttcg attcaatata aaaattaaat
    37741 atatctcgtt tttagtaaat tttacaatat tatacactaa atatgtcaaa acatcttctt
    37801 gaaatagatt atcttgtcaa acaaaaaaag ccatttcagt aaaagcttct gcttaaattg
    37861 aaatgacttt tcttatttaa attattaatt ttataccata ttttcattaa gctaacatat
    37921 gtaatatttg agttaccata agagcacaat aagtccctat aatatttcct agaagcccca
    37981 taagtacacc tactggtatt aatacaggat tgtgaacccc agcaatcatt ggagctgtag
    38041 ttactcctcc tatattagct atacttccta cttcacaagt aaataaatca agtttaaata
    38101 gtttagcaag ccctataaat gaaatagcat gtacaaggac tactaccaat ccaaacatta
    38161 tgtaaacagg tgcttctgac aatccaaaga aatttgcttt actacctgta gctgcaagga
    38221 gtaaatacat aaacacattt cctaccagtg tactcccttt aagctttgat atttttgtca
    38281 tacccaataa tattgatact gtagatgcaa caagtactac ccacatagtt tcattaagta
    38341 tacctgaagt tggaagtatc ttggatacaa tttgtgcaaa agacgcaact ccaaacccaa
    38401 cagaaagtaa aatcataagt tctacaaacg taggtgctgt attatcttta ttttcttttt
    38461 caagttttga tgtaacctca tctataaaac ttgtatcgca ctttgtccat ttgttaaatt
    38521 taggtccaaa tttcacagac attagacaaa cagacatcca tactgtatat cctatagaac
    38581 ccataagtat tgcataacta agtccttctt ctgcaactcc tagagcatta gctgctgcaa
    38641 tcatatttga tgagccacct atccatgaac cagatgctgc cccaagaatt ttccatgaat
    38701 ctgcacccat tgaattttta aaaattatga atgctataac aaatccaagc ataaatgtaa
    38761 atgtagcaca gaaaaatgat aataacattt taggccccat ctttaatatt tttcttaaat
    38821 cacattgaat taacaaaaac actaacatta atggaaggaa gttcactgtt attatgtttt
    38881 gatacgttcc aacatcttca ttctgtgcaa ataaaccaaa tgatccaagt atagctgaac
    38941 ctaagtatat taaaagcatt ggattaataa catcaaatac cttccatttc aatttatcaa
    39001 ccataaaaaa aattacacct acgaatacaa ccaagaaact acaatataca aatccagtct
    39061 caatcacatt atacacaccc tttcttttcc taattaattt gatttttatg atttctaagt
    39121 aaagactttt tcagataata gacaattaaa ataaatactt ttatctatat catgctaatt
    39181 aaatacatat atacctaact attgacatat attaataaag atttgcacat taattacttt
    39241 agaaatgaat aatctgaatt taaaatcttt ttcaacaatt attttattac taaaattttt
    39301 atttgtaaag ataattaaac taaatatttt attatttatt tattttgttt tgtatttatt
    39361 tttattaatt attaaataaa actattttta ctttaaatct atataatata aatcaaattt
    39421 attttatata cttttttttt aaatatgttt agattctatt cttttaattt tagttttcag
    39481 aacatttgta tttatgttat aatttgtata aatatattta tttaggagga aacaatatga
    39541 atttaaattt aactaatact ataaatttaa tgaaaaaata tttggacatt ccaagcccag
    39601 ctggatatac tgaaaatgca gttttagaaa tcaaaaaaga ttttgaaaat ttaggtcttg
    39661 acactattct tacaaaaaaa ggtgcactta tagctactct tcctggtgaa gatgattcaa
    39721 atcaaataac aatatctgca catatggata cacttggagc tatagtaaaa gaaatatcat
    39781 ctgatggtac tcttaaatac cataaagttg gtggtggatg ttgggcagct atagagggag
    39841 aaaactgtac tgttataact agaaaaggta aaaaaatcag aggaagtgtt gtatttaagt
    39901 atgcttctac tcatatatat ggtcaaacaa aagctgccac tgaaagaaat gaagaaacaa
    39961 tgattattag acttgatgaa aaagtattta caaagcaaga tgtattagat ttaggaataa
    40021 gtgttgggga ttttgtatgc ctagaccata gatttgaggc tacagaatct ggttttataa
    40081 aatctagata tatagataat aaatcagctg tagcaatggt tcttgaaata tgtagatatt
    40141 ttaaagaaaa caatttaaca cctaagcata ctactaactt ttatataagt aattatgaag
    40201 aaattggaca tggtgtttct aaatgtttac ctgaaaaaac aaaagaattt gtagcaatag
    40261 atatagcacc tactggacca agtcaaacat ctagtgaaca tggtgtaact atagttgcaa
    40321 aagataattt atcattatat gattttaatt taagaaacaa gcttgttgat gttgcagaag
    40381 acaataattt agactacgct gtcgatgtat ttactttcta tggttcagat gcttcagaag
    40441 ctattcgttg gggagaagat gttcaaatag catgtgttgg tcctggaaca aacaatagtc
    40501 accattatga aagaacacat atagaagcta ttgaaaatac actaaaatta cttataaatt
    40561 atatgcttaa agaataatta attatatatt ttaccaaagt caattcttaa caaataatta
    40621 actttaattt ttatttttat acaaaaattg gtttttctat agacttaatt tcaatttact
    40681 actattatat aagtaacttc aattttcttt agttaatttt tattataatt tatataaatt
    40741 gtataaaaat tttcttcagt tacttgttgt taaattaaat ttttacaagc taaccctacc
    40801 agaaaagagt tatctaatct gtaaggaaat agtttaatat agcacattat acttgtgtaa
    40861 ttaataactt ttcttttgta gaaacttttc tttacaaaga aaagtttttt gattttggat
    40921 ttgtttaaga catattttct gagttaggag gatatttatg aaaaaggttg cagttataag
    40981 tgctattttg gaagagccaa aagaatgtca atttaaattc aatgaggttg tatcaggttt
    41041 taaaggtatt attaaaggaa gaatgggcat tccttgcgaa gaagaaggtg tctcaatcgt
    41101 atgtatagca gttgttggcg aaatggatac tattaatagt ttgactggta aattgggcaa
    41161 catacctcat gtatctgtaa aaactagtat atcaaaaaaa gaagtttaag gtggtgagta
    41221 caaatgagtc taaattctac tccacaatcg gtaagagtac atataggtct ctttggtaaa
    41281 agaaatgcag gtaaatctag cataataaat gctataacaa atcaaagtgc tgcaatagtc
    41341 tcagatattg ctggaactac tacagaccca gtatttagac caatggaaat ccttcctata
    41401 ggaccttgtg ttcttataga tactgctggt cttgatgatg ttggtgaact tggtgaactt
    41461 agaataggta aatcactaga tgttttagaa aagacagaca tagctttact agtagtggat
    41521 tgccagattg gtatatcaca agaagatttg tcactaattg aaaagtttaa tgataagaat
    41581 atccctcata ttctaattct caacaaaatt gatactatta agaatcaatc agaaatttta
    41641 aacttaacta aaaataaagt taaatgtcca gttgtttctg tctcatcaac agataaaatt
    41701 ggaattgaaa atttaaaaaa tgaaataata aaagttttgc ctaaggatag cactgagttc
    41761 aaattggtat cagatttaat tgaaccaaat gatttaattg ttttagttgt tccaatagat
    41821 aaagcagctc caaaaggtag acttatactt cctcaacagc aagttataag agatattttg
    41881 gatagtggtg caatttctat agttacaaaa gaagatagtt taaaagaaac tctatctaat
    41941 ttaggcaaaa aaccaaaact tgttattact gactctcaag tatttccaca agtagataaa
    42001 gatacaccaa aagatattcc tcttacatct ttttctatat tgtttgctag acaaaaggga
    42061 gaccttaaag aattgattaa tggcgcttat gctttagaaa atttaaaaga tggtgataaa
    42121 atcttgatgg ccgaaggatg tacccatcat agacaaactg atgatattgg aacagtaaaa
    42181 attcctaata tgattagaaa gaaaactggc aaaaacatta cttttgaatt tagttctgga
    42241 gtatccttca ctgaagatat aaataaatat gcccttgtag ttcactgtgg agcttgtatg
    42301 atgaatagag ctggaatgtt atctagaata gaaaaggcaa aatctttcaa tgtacctatt
    42361 gtaaactatg gtatcttaat agcatatgta aaaggtattt tggaaagatc acttgaactt
    42421 ttcaattatt aaaaatttaa ctatacttaa taattatata tttgaatatg actaaaaata
    42481 agattaaata ctttatagat aaactttaca gcattaattc attaagtttt gatgaactac
    42541 tatatttaat agaaaatatc gacaatgagg aatataactt cgaacaaaat ttaagaaact
    42601 atctttataa acaagctagc gacatgagaa ataaacatta tggaaataga gtctacttga
    42661 gaggacttat agagcttaca aactattgta aaaataattg ctactattgt ggaatacaat
    42721 cttctaataa aaatatcata agatacaggc tttcacttga tgaaatactt gaatgttgtg
    42781 atataggtta taaaatagga tacagaacat tcgttttgca aggtggtgaa gatgcatatt
    42841 ttactgatga taaaatatgt gaaattgttt caagtataaa aaataaatat gaggattgtg
    42901 ccataactct atcactagga gaaaagagtt atgattcgta taaaaaatac tttttatgtg
    42961 gtgcagatag atatctttta agacatgaaa ctgctacaga cagtcattat aaaaaattac
    43021 atccgccaaa cattgagctt agaactagaa aagaatgcct aaaaaacctt aaagaaattg
    43081 gttatcaggt aggtgctgga tttatggttg aatcaccatt tcagaacaac gaagaccttg
    43141 ttcgtgattt attataccta aaagagttaa atcctcatat ggttggaata ggacctttca
    43201 ttccacacca tgatacaatt tttaaggatt ataaacatgg agatttagag aagacattac
    43261 ttatgctttc aattacaaga cttctacttc caaaagtttt attacccgct acaacagcct
    43321 tggcatctat aaaccctagt ggtagaaatg caggtctttt agctggttgc aatgtaatta
    43381 tgccaaacct ttctcctcaa gaatttagaa aacaatattc tctttacgat aacaaagcct
    43441 ttactggtca agaagcttgt gaatatcacc aaagtttaga agaaaacatc aagtcattag
    43501 gacttgaagt tgactattct cgcggtgata atattgaatg gaggcgtttg taaatgttca
    43561 taaaccatga acttattaat tctttattag aagatgcaaa aaattcaact tctgatgata
    43621 ttgaaaaggt acttgataag gctgatagaa gggaaaaact tagttataaa gatatagcta
    43681 cacttcttga agtagaagat aaaaaacaac tagatagatt atttagtata gctgggcaaa
    43741 taaaaaatga aatatatggt aatagagtgg ttttatttgc ccctctttat gtatcaaact
    43801 actgtgtaaa tgaatgtgtt tattgcggtt ttagtaaatg caacaaattt aaaagaaaaa
    43861 aacttaccat ggaagagata agggaagagg ttaaaatatt agaaaaaatg ggtcataaaa
    43921 gacttgctct agaagctggt gaagacccta aaaattgtga tataaattac atcttagatt
    43981 gcttagatgc aatttattca acatataatg aaaacggaaa tataagaagg gtaaacgtta
    44041 acatagcagc tacaagtgta gatgagtata aattactaaa agaaaaagga ataggaactt
    44101 atatattatt ccaagaaact tatcacaaac caacatttat aaaaatgcat ggtcaatcta
    44161 taaaaaatga ctattattac catttaacag cttttgatag agctatggaa gctggtgttg
    44221 atgatgttgg tgcaggagtt ttatttggtt tatctgaccc taaatttgaa gttctaggac
    44281 ttatgatgca caacgaacac ttagaggaaa aatttggtgt aggtttccat actatatctt
    44341 tccctagatt gaaaaaagct gaaggtatga gcttagaaga ttttcctcac ttagtttctg
    44401 acgatatgtt caaaaaaata gtagctataa ctagattagc tgttcctttt actggaatca
    44461 taatgtccac tagagaaact gctgaaatga gaaatgagtt actaaaatat ggtgtatcac
    44521 aaattagtgc aggttctcta acaggtgttg gaggatataa agcatatgaa gatggtgaca
    44581 atacagaaca attcgaagtt ggagaccata gaagccctgt tgaggtgctt aaagaactga
    44641 ttactgatgg atatatacct agttattgta cagcttgtta tcgtaaaggt agaactggcg
    44701 atagattcat gagcttagct aaaagtcgac aaatccataa tgtatgtaca ccaaatgctc
    44761 ttactacatt aaatgaattt ttaatcgatt atggagatga agaacttaaa attatgggta
    44821 aaaaacttat cgcagaagaa ataggtaaga tagaaagaga agatataaga aacatagtat
    44881 ctaacaatat gactgcctta gagcgtggag aaagagattt atacctataa aattttatta
    44941 cttatatatt atttattgta tattccatag gttagtagta atattatcta aagggaaagt
    45001 ttaagggagg gagattaaca ttgaaagata acaacaatac caataaaact attcaatttg
    45061 gagaaaaaaa agctagcctg gaaaacaata ttcaaaaaaa taaaaatatc aaacttgata
    45121 atacacacaa agtcattcct taccctaaaa atagaaaaaa ggatgataaa aagaaaggta
    45181 acaagaaaaa gaatacaaat acatctaaag taaataaaaa taattatggc cattcttttt
    45241 tcaataacaa atacaaatat aaaagaaaac catatgttat tgctttatac acagtaattc
    45301 ttattctttt agctatctta attataacta aattaacaga tagtacgaat aaaggtaatt
    45361 attctcgtaa tactgtctct gatactcaca aaaacgacat ccgaaatata gtctttaatg
    45421 aatcaaacaa ttttcttatt tgtgggtaac ttaaaagagt tatctctttt cagaaataat
    45481 tttctaaaat tgagataact cctattttca tttaatattt attttaccaa ccttgagtta
    45541 cttcatatac ttcatcacca attctaccat ttaaataatc atctattgca gaatctatga
    45601 tattcattgc tttatctact tgctccttag ttattactag aggtggttgc actcttaaag
    45661 tagattgtcc taagaatatc attattaatc cagtttgtat acatctataa catatcttag
    45721 ctgtagcatc tggatgtttt tcattagaac cttttccttt aactatatca actcctatag
    45781 ataatcctat gcctcttatt tctccaatta tatcgtattt ttcttttagt ttttcaaatc
    45841 ctgctttaat ataatctccc atttctatac tcttttgaag taagttttct ttttcaatta
    45901 tctctataga ttttaaagca gccacacata ctgttgtgtt tccagctaaa gtaaataaat
    45961 gtgctggtgc atcaagactt tgcattattt ctgttcttcc aacaactgct cctagaggta
    46021 atccacctcc aacagatttt ccaagaacta taaggtctgc ttcaacacca aaattttcta
    46081 taccaaacca cttacctgtt cttcccatac cttgttgtat ttcatcactt acaagtaata
    46141 ttccattttc tttacatatt ttacttaaac cttgtaccca ctctactgga ggcactatta
    46201 ttcctgcatc tcctgcaatt ggctctataa atattgcagc tacctcttct gctggtagat
    46261 agtgtgcaaa agcatattct atctcatcta aacattcttt agctgttcta tttttatcag
    46321 gataatggaa gtgataaact tctggtaaca atggacccat ttttcttctc atatttgtac
    46381 ttaaagcaga tatagatata gctccataag tacttccatg ataagattca cacatagata
    46441 ttatctttgt tcttccagta taccctcttg ctaattttat agcagcatct atacaagcag
    46501 aaccagttgc actgtatagt acttttttat cattatctcc aggggctatt tccacaagct
    46561 tctcagctaa ttttacagga ggatcactat ggaaatatgc aagtgtatat tgtgttatat
    46621 catccatttg ttctttaact gcttgtgaga tttccttatt accatgacct acatttgcag
    46681 agcctgcact tgctaaaaaa tctacatatt cattaccttc ataatcatat agcattgcac
    46741 catcacctga tttaaatgct actggataat aaggtatctt ttgagtttta gcaacatatt
    46801 ttttttcttc tgtacttatc atttgactag ttatctcgct cattggcaaa tcatcccctc
    46861 tttaaataaa tttatgtttt aaaattattg cgatttataa agatattctc atataaaatt
    46921 ctttatatac ttaatgttag tatttttgac acaaattgtc aatatatgtt tttataattt
    46981 tcaaaatatt tgttattcag aaacaatata ttttattttt atcaaataaa cattattttt
    47041 caaaaaataa aggactctat tctattttta tagagtcctc tgaaaatcat cttataaata
    47101 ccattattct attcgtcttc attaaattgt ataattacct tttctcatta ataatttttt
    47161 taaaatgttc tagttgctct tgttgttttt tatgttttat atgtggaaaa gcttttataa
    47221 ctcttttttg taaaataata ttagactcta tacggtccaa cttactattt attttgttta
    47281 ttttttctct aacttctaat tcgtcgttat ttattgtttt aaataaagct tgtatttctc
    47341 ctctatcaaa tttatccaat ttcacattta tatcattaag gtctgtaatt atatcgtcta
    47401 ataagtttaa ctttatatct aattttttaa gtgttataat agtaacaatc aaatcaagta
    47461 tagtccaaag tgttgtaatt atagccattg aaattaatat tctatatgga attatactta
    47521 caaaatattt tataaatgga tgtataaatc ttattattaa aacagacatt acaccaaagt
    47581 atattgcatt ttttaaacat actctaccct ttatattgaa ttttttgtca gaataatccc
    47641 accatttagc atgaaataag gtttctaaaa taaatcctgt aaaatattct agtatcgtag
    47701 ttaaaatcat tcctaataga aatactatta ctacattatt aaatcttccc aatagtgata
    47761 tcacaattac cgctccaaaa ccataaacag ggcatattgg accatttaaa aaacctctgt
    47821 tgattattct tttgcttgct atagaacatc ctatactttc tactgtccat cctaaaaatg
    47881 aatatataaa aaagtacaag atatatttta ttatctccat aatttatctc tactccttca
    47941 ctaatgttct tattttatgc acaacgtaaa aataattata gaaatagttt tttcgttttt
    48001 tatatttgtt attcttttat tcttgtttaa tattttattc atacaatcca attaataatt
    48061 tactagccat aataccatgt ttatcctttg gctgattttc tttatcaatc caaacattaa
    48121 tagtatcata tctccttaat aaatctaaat tcttcacatc aaattcctca tatttaacta
    48181 tatccatttt tgattctttg gtaattatat aagatactaa ttttgtattt tcatttaaat
    48241 aaattcttat atttccatca gaatcaatta aattctctgg tctctttact ttgttattag
    48301 aacctgcttt aatagttatt attccttttt taaagctctc aaatgtccca actatatcta
    48361 ctgtatcttt atttatatct ttaattattt ccctattttc ttcaattaat atttttgata
    48421 tttttctatc aggtctaaat ttaaaagtta gtaagttatg ataattttta gaaataactc
    48481 ctaatcctat aactcctaaa actaaactag tacctattat agccttaaat ctgttaatat
    48541 cattgggaaa taatttattc atgtttatgt aaatattaat tccaattatg ccacctaatg
    48601 aatttaaaat aacatcatct atatcactac ttccaagagc aaaaatatat tgtgttaatt
    48661 caaatgctag gctaacaagt ataattacta taattatagt ttttttattt agatttttac
    48721 atactatagg taaaaaaatt cccataggaa taaatatacc tatattttct ataatattta
    48781 cagtagcttt cataaagtca agattactat ctactataaa ttgatatatt gtataaaatg
    48841 gaattaaatt tacattccta aacgttccct tgaaaatagc gtaaattggt acatctctaa
    48901 ataaaattat tcttataatc attaaaatat ataccaaaaa tattatgtat ataattgaca
    48961 gtaacaattt ttctgacttt ttactttcta tcactgataa gtctcctttc gctattaata
    49021 ttttaagtat atcaataaat atttaagacg attttaaaat ttccttaaaa tttccttaat
    49081 tttcaaacaa aaaatcaaaa aagcctacac ttaaatgtgt agactttaat aaattttcat
    49141 acaaatacat tttattgaat aacgaacaat cttaatgtag aaaaaactat aactacagtt
    49201 aaaagaagtc tagcatataa aaaatttttt tctttcaaca taactcctgc aactccaaat
    49261 ataaaaaata gagaagcaat aaattttcca ataagattat tattaggata ataactaaaa
    49321 agcataaaac aaagtacaaa tgtaagtact cctattgcat taaacacaat tttattagat
    49381 gctatttttc ctttattgaa aaagaaacag aatattgaca ctaagtctaa aaataaaaat
    49441 acataaaaca ttccttttaa aacgcccatt tttatacccc ctaaaaattc taattataat
    49501 atccagttta tttcatataa tcgtcaatat aatcaatact ttataacatc agtataacag
    49561 tattacaaat ttatattacg aatgtattac ttcgtattca tacatattat aatcacactc
    49621 atacatattt aaagactcat atgttgcttt tgcatttatg ttttcttttt ctacatataa
    49681 tctcattcca actatatttt catctttatc acatatattt tttatataat taaataaata
    49741 attaaagata ccttttcttc tatattcctt atctacatat acactctgaa tccaaaggaa
    49801 atttccattt ctccaatcac tccactcata tgtatacata atctgtgcaa caactttatc
    49861 aaatactgta tatacatgat attttccttt tctctcatct aataacaatg cttttacacc
    49921 tttagttaaa acatccatat caagttcttt tccttcagtt tctttagcca aattataatt
    49981 aaattttgct attgtatcca aatcatccat acgtgcttct cttatctcta ttagttcttc
    50041 attttcatat aactctatgt agtccttttg ttgctccata cttattcctc catatctatt
    50101 ttatctacta aggtttttta tataatatat ttatagagtt ttttctatct tcataaatgc
    50161 ataatcaagt gtagcctcta aatttccatt attcttacct cctccttgag ctaatacttt
    50221 acttccacca cccttgccat ctataagact tattgcatcc tttaataaaa ctcccatatt
    50281 aatatctttt aaatttttag aacatgcaaa aactaaattt attttatcat taaatttaac
    50341 agctaataat gcaatactat tttcatattc tgcaatttta tttgctatct tatttacata
    50401 tttcaaatct tcatcatcat aaattttttt aatgaccgaa atattgccaa ccttatttgc
    50461 tttttcaatc atttctttga cctgatatgt agatactact tcttcaagcc ttcttttttt
    50521 aattaaagcc tcttccactt tactatttag atttacaata ccatttatag catcttcctc
    50581 actacagctt aaatatctac atattttagt caaatatata tccctcttca atacttcatc
    50641 cactgccctt ttacctgcta gaaactctat tcttgtactt gacttatgtt tttcccattt
    50701 ctttattttt atcattctca attcaccagt tgattttgga tgcactccac aacatgcatt
    50761 cgtatctaaa tcacctattt ttattactct tatctcttca tcagtatttg gcaaatcacg
    50821 tcttaaccaa atctttttta gttctttttt cgttggaagt aatgtctcta cttgtatatt
    50881 ttgacgaata atttcattgg caaacaactc tatctctcta attttatcct cttctaaatt
    50941 accttctata tctactgtac tatactcatt tcccaaatga aaacctgtcg tatttgcatt
    51001 aaaagtttta aaaaaacatc cagacaatac atgttgtcca aaatgttgat gcattccatc
    51061 ttctcttcta tcccaatcaa tactacactt taccttatgt atctttatag gttttttatc
    51121 taatacatgg tatatttttt ttccatcttc atacacattt attacatcat cactctctat
    51181 ttttcccagg tctccaaact gacctcctcc accaggaaaa aaagctgtct tatctaataa
    51241 aacatgatac ttattttcta cttcttttat ttcaattatt tctgctgtaa aatctcttat
    51301 atactgattt gtataatata acttttccat tataattcta tctccatttt cttaattcta
    51361 gattacttta ctttttagat acaaatttca aactaagctt aatttaattg tattaaaata
    51421 gaactcatcc tattatttac taacatcttc tactatattt taacatatag atattagtgt
    51481 taacaaattt ataattgtat attattccaa tattttataa catgtatgtt tacttatttt
    51541 cttatataat aaaatgtata ttaaaacatg ttaaattgca aaataagctt caatctcttt
    51601 tactaatttc atccattatt aatgattttg aaatatacat tacttctata atattcttaa
    51661 aacgtgtatg atgagatgtc tcctcagaaa atttcttctg tccttttcca caattaataa
    51721 tacttgaaga tactactctc agtgcttcca ccaattcttc ttttgtatga taattcataa
    51781 cacatttact cctttatttt ttaatttaga gaaacagtat atctcaattt aatatcatta
    51841 taaactgaca tcattattat ttatacacat cttttagcac ttaaatattc taactatcag
    51901 tgacattaca tattttaata attattaata tacatataat actttaatat tcactaatag
    51961 agagtatatt aac
//
LOCUS       DAEPID010000024        50618 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.024, whole genome shotgun sequence.
ACCESSION   DAEPID010000024 DAEPID010000000
VERSION     DAEPID010000024.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 50618)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 50618)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..50618
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.024"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            41..766
                     /locus_tag="KR257_001511"
     CDS             41..766
                     /locus_tag="KR257_001511"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007860183.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bclB domain-containing protein"
                     /protein_id="HBH0030220.1"
                     /translation="MAGATGATGPTGATGATGADGATGPTGATGATGADGATGPTGAT
                     GATGVTGATGPTGPTGATGATGATGASAIIPFASGIPLSLTTIAGGLVGTPGFVGFGS
                     SAPGLSIVGGVIDLTNAAGTLTNFAFSMPRDGTITSISAYFSTTAALSLVGSTITITA
                     TLYQSTAPNNSFTAVPGATVTLAPPLTGILSVGSISSGIVTGLNIAATAQTRFLLVFT
                     ATASGLSLVNTVAGYASAGIAIN"
     gene            935..1696
                     /locus_tag="KR257_001512"
     CDS             935..1696
                     /locus_tag="KR257_001512"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429711.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="epoxyqueuosine reductase"
                     /protein_id="HBH0030221.1"
                     /translation="MKNKIEISMNNFVKNYHKSNNITTKWQELLFAYASAEDDMFQKL
                     KSVVGTSHAMPKDFLENGKTIITYFIPFDESVNNSNIGGFECSEIWARAYIETNMLIS
                     NLNDFLCEELEKIGANSYAIPGSYNFDSEKLVSDWSQRHVAFIAGLGTFGLNNMLITE
                     KGCCGRIGSIITSLELEPTKRPENEYCLYKHNNSCKKCVNKCVKEALKEDGFNRNKCY
                     EMCMINEKKYTYIGGCDICGKCIVGVPCSVINPSR"
     gene            2005..2283
                     /locus_tag="KR257_001513"
     CDS             2005..2283
                     /locus_tag="KR257_001513"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429712.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0030222.1"
                     /translation="MSYKKAIHILPEELLELIQEYVDGECIYIPRKSNNKKEWGSNTP
                     TREELSIRNMQIYEDYQVGYDLQYLSEKYYLSLKSIQRIVLQEKRKDI"
     gene            2576..3151
                     /locus_tag="KR257_001514"
     CDS             2576..3151
                     /locus_tag="KR257_001514"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891809.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1062 domain-containing protein"
                     /protein_id="HBH0030223.1"
                     /translation="MKKITWEVEYISQLPVIRYCKKCGKKTEYICSGLFRVNAQHKYL
                     DIWLIYKCSNCDSTWNSTIYSRVNPKSLNPEILEQFHTNDYNLVKQYAMNMELLHRNG
                     AEVGIPEYKIVGQEININDLTQVHIISKYPCQLKVSTLLREKLGLSRKVFDEMLDCGI
                     IRSNSGVDLKKGKLNYEIMLDIGKEKQKSSN"
     gene            complement(3257..4090)
                     /locus_tag="KR257_001515"
     CDS             complement(3257..4090)
                     /locus_tag="KR257_001515"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891800.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="prenyltransferase"
                     /protein_id="HBH0030224.1"
                     /translation="MNVENQSLSDIEIILSHRYDNGADYWTTPDKRLIKGSPFSTLDS
                     VLYLLELGVNPDDTLLKECADLIFSTWREDGRFKLYPNGGIYPCHTANAANVLCHMGY
                     ASDIRMQKTFQHFLDTQYTDGGWRCNKFSFGRGPETEYSNPLPTLNILNAFRFSNYLN
                     KESKLDKAVDFLLDHWTIKKPIGPCHYGIGTLFMQVEYPFRNYNLFLYVYVLSFYNRA
                     KKDKRFLEALKILESKMIGNKIVVERVVPKLSKLSFCKKGESSEIATTHYYEILKNLE
                     K"
     gene            complement(4158..4787)
                     /locus_tag="KR257_001516"
     CDS             complement(4158..4787)
                     /locus_tag="KR257_001516"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903713.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3786 domain-containing protein"
                     /protein_id="HBH0030225.1"
                     /translation="MDEKITKNNYNVPFDYVRKKLKELDPHTISNLSNIPFNNDLNRF
                     TLNFFDRQYIIDYPSGEVWNSNGSLCNNFELKILIVRYLINAKGIPRTNKYVTFKEIP
                     GGNVYYPNFLNRTLYRLSEVFTSQIDKYKLVMEKIGAEKVNMGDLAYRFTYMGNTSMV
                     FILWFGDDEFPPNSNILFDSNIVYYFNAEDLAVVPDTAINAILNKINQL"
     gene            5098..5757
                     /gene="cprR"
                     /locus_tag="KR257_001517"
     CDS             5098..5757
                     /gene="cprR"
                     /locus_tag="KR257_001517"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437316.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="two-component system response regulator CprR"
                     /protein_id="HBH0030226.1"
                     /translation="MSKILVVDDELDMLKLIENVLKRDGHEVKVISDVEKAMNMDFNY
                     FNLIILDVMMPKMDGFEVCKTIRNKVDCPILFLTAKNMESDIMYGLGIGADDYITKPF
                     GVGELRARITAHLRRESREKKNLLTISNVQFNFLGKEVSIDGKKINFTKSEYLICEFL
                     AKNKGQVFSKERIYESVYGFDGESDISTITEHIKNIRSKLKQYDIYTIETVWGIGYKW
                     V"
     gene            5968..7026
                     /locus_tag="KR257_001518"
     CDS             5968..7026
                     /locus_tag="KR257_001518"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003417031.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flippase-like domain-containing protein"
                     /protein_id="HBH0030227.1"
                     /translation="MDRLKNIRKSLLQYTFLFLLIGITIYLVFKTLDIKMLSNVMVMV
                     DKKFLFIGALAIMCHIMLEGVVMKIIIESTHKVNIRFIGFKLAIMGFYYNLITPFASG
                     SQPVQIYVLKKCKMPLSKASAVVTNKSIIFQIVVTFYCTILVLMNFAMLEKQMKMIMP
                     LVFLGIAINSFVLIMIILVILNPKKIKYFMRITIKHLSKIKFLKFLDNKIESIESFID
                     DYSKAINFFAKNKKVLISTIIVTFIQLSAYFSVSFWIYKAFNLQGYSYIYILTLQAFL
                     YMAISPIPTPGNVGANELAFFTIFKSVFPQPLMGYAVFLYGGFMYYLILIGSGIFTVI
                     THYRMKNRIGRNIVLSEN"
     gene            7277..9421
                     /locus_tag="KR257_001519"
     CDS             7277..9421
                     /locus_tag="KR257_001519"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861905.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_except=(pos:7691..7693,aa:Sec)
                     /transl_table=11
                     /product="formate dehydrogenase H subunit alpha,
                     selenocysteine-containing"
                     /protein_id="HBH0030228.1"
                     /translation="MEKKILTVCPYCGAGCQLYLVVKDNKILRAEPANGRTNQESLCL
                     KGRYGWDFLNDPKILTPRLKKPMIRKQGVLEEVEWDEAINYTASRLNEIKEKYGPDSI
                     MGTGSARGPGNEANYIMQKFMRATIGTNNVDHCARVUHAPSVAGLAYSLGSGAMSNSI
                     PEIENADVLFIFGYNGADSHPIVANRIVKAKKNGAKLIVTDPRVTESARIADIHLPIK
                     GGTNMVLVNAFGNVLIEEGLYNKEFVQNHTQGFDEYKEIVKPYTAKYAEKITGIPEEL
                     IRKAMREYAKGKKAMILYGMGVCQFGQAVDVVKGLASIALLTGNFGRESVGIGPVRGQ
                     NNVQGACDMGALPNVYPGYQNVTDDKIREKFEKAWGVKLSPNNGYSLTQVPNLVLKEK
                     KLKAYYIFGEDPVQSDPDASEVREALDELEFVIVQDIFMNKTALHADVILPATSWGEH
                     EGVYTCADRGFQLMRKAIEPQGDVKPDWQIISEISTAMGYPMNYKNTKEIWDELRQLC
                     PSFLGATYEKIETQGCVQWPCKSESMEDKGTMYLYEGQKFSTPNGKGNLFAAEWRPPM
                     EVEDDEYPFSLCTVREVGHYSVRTMTGNCRTLSSLEDEPGRVQINSNDAEKLGIEDDE
                     LVRISSRRGSVITRATVTDRVKEGATYMTYQWWVGACNELTIANLDPISKTPEYKYCA
                     VKLEKLEDQELAEKCVREEYQSLKDKMTATNI"
     gene            9470..10303
                     /gene="fdhD"
                     /locus_tag="KR257_001520"
     CDS             9470..10303
                     /gene="fdhD"
                     /locus_tag="KR257_001520"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003417034.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="formate dehydrogenase accessory
                     sulfurtransferase FdhD"
                     /protein_id="HBH0030229.1"
                     /translation="MNNIYSKTKLQENSKDKVFENSYSLVDYKYLNSFNVEVSKINEH
                     EVSIDNEEIIAEYPLSFILNDKYINTFLCTPYNLEELIVGFLKTKGYIENKKSLLKFE
                     INESERFAKVTIQEKQKNQDEQIIFLNSLDYITCAPVKSNIKINYDTIYSIMDRNLNS
                     SELFKNTGGVHSVSVFNFDKKIVTCEDVARHNAMDKAIGFCVLNDITLKDKIVAVSGR
                     ISLEMILKAAMTQIPIVVSKSAPTNLSIELSKKLNITLIGFVRGRRMNIYANPQRVIK
                     K"
     gene            10314..10487
                     /locus_tag="KR257_001521"
     CDS             10314..10487
                     /locus_tag="KR257_001521"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891795.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0030230.1"
                     /translation="MCTKKEEQRYSKCEICGVLIDDTDKVYNNTYNLCKKCKRNISTE
                     KIVKYINIYDESK"
     gene            10545..11096
                     /locus_tag="KR257_001522"
     CDS             10545..11096
                     /locus_tag="KR257_001522"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003432405.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="4Fe-4S dicluster domain-containing protein"
                     /protein_id="HBH0030231.1"
                     /translation="MKNKIGSFVIADPNKCTGCRACEVACFTMHNQHNNVGYTVGTVD
                     IPVIPRLYLVKGDNFCMPIQCRQCEDAPCLNSCPQKAIVKENNIMSVNEEKCIGCKTC
                     LLACPFGAIDLLPQYEDGKEVEQVILDENKKIAYKCDLCKDNEKIACISACPQEALKL
                     VTPIDDKKAKNRQAALSLLLTNK"
     gene            11121..12497
                     /locus_tag="KR257_001523"
     CDS             11121..12497
                     /locus_tag="KR257_001523"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429061.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="iron hydrogenase small subunit"
                     /protein_id="HBH0030232.1"
                     /translation="MIINIDKDLCTGCRECSKVCPVNAIEGEEGKPQEINLDRCVMCG
                     QCVQTCKSYASVIDEGFEFLQEKKQEREIPESINEPIFAAYNVCDIDKVKKALSDPNV
                     FTMVQCAPAVRVALGEDFGYYLGYLGAGKMAAALRALNFDRVYDTNFAADLTIMEEGS
                     ELIKRVTEGGTLPMFTSCCPAWVKFMEKNYPKLTNHLSSCKSPQQMGGAIFKTYGAEI
                     NNVDASKIFSVSIMPCTCKKYECDREEMDSSGYRDVDVVLTTRELAYLIKDMGIDFKN
                     LREEKFDSPLGSYSGAGTIFGVTGGVMEAAIRTGYELITGESIPDVEVKQVRGENGFR
                     KSTIKIGDLDLRVGVVSGLKNVIPVLEDLEKGKLDVDFIEVMTCPVGCVSGGGQPKIL
                     LEEYKELAYENRTKATYVHDEHLAIRKSHENPDIKKLYDEYLVEPLGEKSHHLLHTTY
                     CIGKEVAK"
     gene            12497..13012
                     /locus_tag="KR257_001524"
     CDS             12497..13012
                     /locus_tag="KR257_001524"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861901.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="4Fe-4S dicluster domain-containing protein"
                     /protein_id="HBH0030233.1"
                     /translation="MNYFVIADPDKCIGCRTCMIGCVVAHSDEDIFYQNLDEINFNPK
                     LSVIKTKEVSAPIQCRHCEDAPCAKACPNGGIVRVGNTIKINEENCIGCKTCMLACPI
                     GAIDIVTLKDVDEGKLCFRERMTANKCDFCIESPEGPACVNVCPTKAFTIVKDEDIDS
                     KVKNKRKLAIL"
     gene            complement(13090..14373)
                     /locus_tag="KR257_001525"
     CDS             complement(13090..14373)
                     /locus_tag="KR257_001525"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003427927.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="conjugated bile salt MFS transporter"
                     /protein_id="HBH0030234.1"
                     /translation="MNTLLNNKFSIKNFSNAWVIVLGCMLIQAVPFSIVASIQPQFIS
                     YVVEGEGFSLASFSLIFTIGTIASAIASPFIGVLFSKVNIKILYLLGCIISSIAFATF
                     SICTELWQFYTVSCIVQIGATIISAIGIPVLISAWFDEESKGKALGFAFAGGSIGSIF
                     LQPLAVRLLATQGYSRSYLIFGIIALIVGIPVILFILRMPKDINEKVKSKGKKEKASD
                     TISPSVWGYTLKEAKKIKYFWIMTIGFIFVGIYVSSLSVQYPTYLRNYLNPILIGTVG
                     STFALFALIGNLFGGLLFDKFGQTKPLIISFVLVLIATLSLLLVDKSSTFAFVFAILK
                     GLSVFAYMIGPAYLTGSFFGQKEFGSIYGIVQLIFAVGFALGSTLFGLLVDNFGYRFS
                     WSIIILSVIIAYTLLIITSIGMKKLNKERLDKLMQ"
     gene            14561..14983
                     /locus_tag="KR257_001526"
     CDS             14561..14983
                     /locus_tag="KR257_001526"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018112711.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3783 domain-containing protein"
                     /protein_id="HBH0030235.1"
                     /translation="MSFEKINNNNLDKIHNRKCIMLVNFNKKELSLIKNVSNFAGIRD
                     HIILSDKNGENIIRDILDGNISNECENGIKSKSVIFNNTPSTQVNAFLEGLKKVRINR
                     PFTAMVTETSIDWTLNNLIENLVQERNAMSLGKTIEHK"
     gene            15085..16023
                     /locus_tag="KR257_001527"
     CDS             15085..16023
                     /locus_tag="KR257_001527"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891785.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphoglycerate dehydrogenase"
                     /protein_id="HBH0030236.1"
                     /translation="MKVLFTINYGKEKFDKIRELGYDVIHYSEDSIENNEDVNTADVL
                     VTYNPFERLDISKMKNLQYIQTTSVGIDQLPKEEVLKRNIKIANNRGGYSVPIGESIV
                     LYILEIYKNSAKFFKQQQNKEWKMDFSVSELYGQRVGFLGTGTISSEAAKRLKAFGVE
                     IWGVNTDGSSKKYFDKCFATEDMNIVFEECDIVVVAMPSTKSTDGIVNKDMFKLMKDG
                     SVFINVGRGNTVNQKDLEECVEKFRGVALDVFESEPLNKDNKLWECENVIVTPHNSWV
                     SDKNKERTFNMVYNNLKHYIMENKPVDNVVDISRGY"
     gene            16209..18233
                     /gene="ligA"
                     /locus_tag="KR257_001528"
     CDS             16209..18233
                     /gene="ligA"
                     /locus_tag="KR257_001528"
                     /EC_number="6.5.1.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861898.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NAD-dependent DNA ligase LigA"
                     /protein_id="HBH0030237.1"
                     /translation="MSVKDEINKLIETINYHNERYYNQDSPEISDYEYDKLMKELISL
                     EEEHPELKRIDSPTNRVGGKPLDKFNQIVHKTPMLSLSNAFSEQDLRDFDKRVQEYVG
                     ENVEYVVEFKIDGLSVGLTYNNGEFEKGATRGDGVVGEDISQNLMTVKSIPLKINDKK
                     ELIVRGEVYISKDNFRKVNEQQEEQEQPLFANPRNLAAGSLRQLDPKLTAKRPLDIFV
                     FNMENIEEYDLESHSESLEYLEKLGFSVSQSYKVCKSIDEVIEHIEYWTDNRGNLDYE
                     IDGMVIKVNNIKQRDEMGYTAKSPRWAIAYKFPAEKKKTKIVDIIVEVGRTGTITPSA
                     ILEPVRLAGTTVSRATLHNEDYIREKDIKINDTVLVQKAGDIIPQVLEVIKEERTGDE
                     IDFKMPEKCPVCSEPTIRLEGEAAVKCINMSCPAQIRRGIIHFVSRDAMNIDGLGESI
                     ITLLLNEKIIQDVSDLYYIKKEDVVDLERMGEKSADNLINSIEKSKENDLWRLINGLG
                     IKFIGVKAAKILAYNFKDLDEVISATSEQLEELEEFGSIMANSVVEFFKEDKNMNVIN
                     KLKNVGVNTKSLDNTGEKVEKIFEGMKIVLTGTLPTLKRNDAKDMIEKRGGKATSSVS
                     KSTTFVLAGEEAGSKLTKANDLGIKVIDEERFLELLKLSSKDEVKAVLES"
     gene            18393..19742
                     /gene="rph"
                     /locus_tag="KR257_001529"
     CDS             18393..19742
                     /gene="rph"
                     /locus_tag="KR257_001529"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435607.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribonuclease PH"
                     /protein_id="HBH0030238.1"
                     /translation="MTRSYDRSNEQIRPVKITRDYTKYAEGSVLIEMGETKVICTASV
                     EEKVPPFLRNSGTGWINAEYSMLPRATQQRKIRDASRGKIDGRTQEIQRLIGRAIRSV
                     VDLNKLGERTIWVDCDVIQADGGTRTASITGAFVAVAEAIYKLYKAKIIKEMPITNFV
                     SAISVGIVNGIHMLDLCYEEDSKAQVDMNIIMTDKCEFVEVQGTGEEKPFSRADLNLL
                     LELGEKGNKELIRLQREALGEISDEILGMDYGNEVVIATNNAHKLEEIGEILKDFEYK
                     VYSLKDVDLAGIEIVEDGKTFEHNALIKARTIAKKTKLIAISDDSGLEVDALGKKPGV
                     YSARYAGEHATDEENRKKLLKAMQNIPMSKRNARFVSAIAVVFPDGKEFVVRGICEGM
                     IGFEEKGKNGFGYDSLFIVKGYDKTFGEIPSVIKNSISHRANALKLMKQEFIKRVVK"
     gene            19742..20212
                     /locus_tag="KR257_001530"
     CDS             19742..20212
                     /locus_tag="KR257_001530"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003427939.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="metallophosphoesterase"
                     /protein_id="HBH0030239.1"
                     /translation="MKIGIVSDTHMMIKNMEKTIPYLKECDLIIHAGDNFTDSRYIHS
                     MTNVGIIAVKGNCDFDAVEEEVVFEVANKTIFLCHGDKYGVKYGTHMLEKKATEVDAD
                     IVIFGHTHTPFREIKDGVLYINPGSTSLPRGVSYKSFVIMDIEEDDIKIEEIRI"
     gene            20406..21692
                     /locus_tag="KR257_001531"
     CDS             20406..21692
                     /locus_tag="KR257_001531"
                     /EC_number="5.2.1.8"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003417090.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="trigger factor"
                     /protein_id="HBH0030240.1"
                     /translation="MKAELIKKEGNKVTLKITVDNNKFEAAVNKAYNKSRNKYNIPGF
                     RKGKAPRIVIETQYGKGIFYNDAIEILFPEVYPEAIKELDIDPIDNPDLDIEEISKDN
                     GLVMVLNVEVKPEFELGNYKGIEIAKVENTVSDENVDAKLQEMVEKNARLVSVEDKAL
                     EDGDTAIIDFEGFENGVAFDGGKGENYNLVIGSNTFIPGFEEQLVGKKAGEEVEVNVT
                     FPEEYHSQDLAGKPVVFNVKINDVKVKELSALDDEFAKDTSEFDSLDELKADVRAKLE
                     EEAKNRADAETRNSVVEKVAENTEIEIPEVMIQHQIDNMLNELNYQLQYQGFGLQQLL
                     EMTGRTMEELREERKEDAKKLVKSSLVLEAITKAEGIEATEEEFKAELEKMASAYNME
                     VEKIEASLRDADKEDIKGQIKIRKTIDLLVDNATIA"
     gene            21842..22426
                     /gene="clpP"
                     /locus_tag="KR257_001532"
     CDS             21842..22426
                     /gene="clpP"
                     /locus_tag="KR257_001532"
                     /EC_number="3.4.21.92"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003417102.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-dependent Clp endopeptidase proteolytic
                     subunit ClpP"
                     /protein_id="HBH0030241.1"
                     /translation="MALVPVVVEQTGRGERSYDIFSRLLKDRIIFLGDQVNDATAGLI
                     VAQLLFLEAEDPDKDIHLYINSPGGSITSGMAIYDTMQYIKPDVSTICIGMAASMGAF
                     LLAAGAKGKRLALPNSEIMIHQPLGGAQGQATDIEIHAKRILKIKETLNEILSERTGQ
                     PLEKIKMDTERDNFMSALEAKEYGLIDEVFTKRP"
     gene            22445..23695
                     /gene="clpX"
                     /locus_tag="KR257_001533"
     CDS             22445..23695
                     /gene="clpX"
                     /locus_tag="KR257_001533"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003417105.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-dependent Clp protease ATP-binding subunit
                     ClpX"
                     /protein_id="HBH0030242.1"
                     /translation="MSKYEEKRQLKCSFCGKNQDQVRRLIAGPNVYICDECVELCDEI
                     IQEEIEDTIDEDTTSLPKPKEMMEILNDYVIGQEKAKKALSVAVYNHYKRIYSKKSSS
                     KDIEIQKSNILLLGPTGSGKTLLAQTLARTLNVPFAMADATSLTEAGYVGEDVENILL
                     KLIQAADFDIEKAERGIIYIDEIDKIARKSENPSITRDVSGEGVQQALLKILEGTVAN
                     VPPQGGRKHPHQEFLKIDTTNVLFILGGAFDGLEKIIQKRGGDKTLGFGAKIESKKEL
                     DLGKLYEKVLPEDLLKYGIIPEFIGRIPVLATLELLDEDALMQILQEPKNALVKQYKK
                     LLELDDVELEFEEGALRAIAKKAIERNTGARGLRSIVESVMMETMFEVPSRDNIKKVI
                     VTEKSVNEDSVNPIIVLKDQEESA"
     gene            complement(23766..24293)
                     /locus_tag="KR257_001534"
     CDS             complement(23766..24293)
                     /locus_tag="KR257_001534"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003427941.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="chromate transporter"
                     /protein_id="HBH0030243.1"
                     /translation="MSEIILLFLIFLKIGAFSFGGGYAMLPFIQQEFISKYHFITNQE
                     FLDLLAISQSTPGPVAINSATFVGFKTAGFFGSLAATIGVTIFALIGLTIISKLFSKF
                     KNNKKVENLLTVLRPITLGFILSAAFSSAKEVNWDLYGIIAFIASFYLLYKGKIGSIA
                     IVFVFGILGILLTFL"
     gene            complement(24281..24793)
                     /locus_tag="KR257_001535"
     CDS             complement(24281..24793)
                     /locus_tag="KR257_001535"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003417110.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="chromate transporter"
                     /protein_id="HBH0030244.1"
                     /translation="MLKLFLTFLKIGAFTFGGGYAMVPLIQDELVNKQKLLEQEEFID
                     YLSIAQSYPGVLAVNISVLLGYKLYGIPGVLICTLGSALPSFCIVLVLSYLYFKNSSS
                     KILDGFFKGVAPVVIALILYSFTSMFKKLPKSKTNILLLIIAVLSVGVFNISPIYLII
                     GGGVYSLCQK"
     gene            24973..27336
                     /gene="lon"
                     /locus_tag="KR257_001536"
     CDS             24973..27336
                     /gene="lon"
                     /locus_tag="KR257_001536"
                     /EC_number="3.4.21.53"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903709.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="endopeptidase La"
                     /protein_id="HBH0030245.1"
                     /translation="MEQNYTKIDHELPLIPLRGLAIFPYMILNFDIGREISLKALDQA
                     MMDEELIFLTSQKEAEVDEPGEEDFYHVGTICKVKQMIKLPGDTVRVLVEGVSRGRVK
                     KIEQEDGYFRAVIEEIVFDSDNLDSETEVEIEAFVRNVFDAFEEYINIGNRVSPEILI
                     SLADIEDVDRFIDTIAANIYLKSSQKQEILEEFDIRKRLELIYSILLEEIDILKIEKK
                     ITLRVKKQMNKVQKEYYLREQLKAIQKELGEEEDINSEADEYREKLKKIKAPKTTKEK
                     IEKEIDKFSKISSMSPDVSVSRNYLDTIFSLPWNKETKDKLDITKAKDILDEDHYGLE
                     KVKERILEYLAIRTLAKSLKGPIICLVGPPGTGKTSIVKSIARALNRKFVRISLGGVR
                     DEAEIRGHRRTYVGSIPGRIINGVKEAQTKNPVFLFDEIDKMAADYKGDPASAMLEVL
                     DPEQNKDFVDHYLEIPFDLSKILFVTTANSLSNIPRPLLDRMEVIEVSGYIEEEKLNI
                     AKKYLLPKQIKEHALKENFIKIDDETLRSIINHYTREAGVRTLERTIGKICRKVAKKY
                     VEDPTLEEVVINKSDLETYLGKDMFKYQLAEVNPQIGLVNGLAWTEVGGVTLEVEVNV
                     LKGKGEIVLTGKLGDVMKESAKTGISYIRSIVDKFDIDPEFYKTNDIHIHIPEGAVPK
                     DGPSAGITMALAVISALTKRPVPGNIAMTGEITLRGRVLAVGGVKEKLLAAHRAGITK
                     VLIPKECEADLDEIPENVKEKMEFVLVEHMDEVLEQALLKSGENNEN"
     gene            27326..27937
                     /locus_tag="KR257_001537"
     CDS             27326..27937
                     /locus_tag="KR257_001537"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891775.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YihA family ribosome biogenesis GTP-binding
                     protein"
                     /protein_id="HBH0030246.1"
                     /translation="MKIRSSEITMSAVNKSQYPAEGIPEIALAGRSNVGKSSIINTLL
                     NRRNFARTSQTPGKTRTINFYLINNEFYFVDLPGYGYAKIAKSEKEKWGGIMERYLES
                     RQELCSIFLLVDIRHEPTADDKLMYEWIKHFGYNCVVIATKADKISRGQYQKHISIIR
                     KKLQMESSEKVIPVSSLKKTGVEELWEEIVNQYNQHGYEITVD"
     gene            complement(28203..29573)
                     /locus_tag="KR257_001538"
     CDS             complement(28203..29573)
                     /locus_tag="KR257_001538"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435615.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MFS transporter"
                     /protein_id="HBH0030247.1"
                     /translation="MKQKWIVLIIICIGVFMSTLDGSILNIANPTIAADFKINMSQIQ
                     WVVTAYMLVVTATMLFFGKLGDKVGSNRLYTLGFFIFTIGSFLCSMSNNLSTLISSRI
                     FQAVGASILMATGLGIVSNAFPANEKGKAIGITGAVVGIGNMSGPVIGGIILEHFGWP
                     SIFIINIPIGIIAVFLGIKFLPKPVLDEQNKSFDIPGLLLFASCTTLILLAMNEKGNT
                     RLYLGITALIIFLLLALREVKFEQSFIDLPLFKNRNFTVGNIIGVACYFPQMAVSFLL
                     PFYLEQLKNLSPMMAGYVMTVHPLIMVLIAPIAGSLSDKHGAKNILTASFSFMTISLV
                     GMALLKADSPLYLLIVCLVIFGLGLGAFSSPNNSSILADVPPQKQGYGGSFLATIRNL
                     SFALGTAFFSSFFAQSLTYNQKFKSHTSAYVIASNQSYWIAASVCFVGLILTVFFMRK
                     TDKSIS"
     regulatory      complement(29748..29863)
                     /regulatory_class="riboswitch"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00050"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="FMN riboswitch; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /bound_moiety="flavin mononucleotide"
                     /db_xref="RFAM:RF00050"
     gene            30151..31230
                     /locus_tag="KR257_001539"
     CDS             30151..31230
                     /locus_tag="KR257_001539"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891772.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding protein"
                     /protein_id="HBH0030248.1"
                     /translation="MEGKVKKAFPGGNTSQGSYSFFDYIIPENVKRVFCLKGGPGVGK
                     SSLMKKIYKEFLHRGYDIDLYHCPSDPSSLDGLVIKKLGVVLMDATAPHTMDPKLPGA
                     LDEIINLGDYWNTEELEKNKQEISVYDKDISNSFKRAFKFLKSAEPIFRDIEEKYSDC
                     MDYGKVNLVTEEFIKRLFDGVKSTGNLKREKHLFGSAITPVGCLDYTENILKDVKKVY
                     YLDGEIGTGKTTLLNKVYKKAIEKGLNVEVYHYPLIPEKIETVLLTDLDIGITISTTF
                     KEEDTIDLNQFLNREKLLKYEEDIKFDEKVLDDLICWAVLNLKRAKSKHDIIESYYSP
                     NMRFDEVGKLRDKLIKRILKYEENL"
     gene            31622..32302
                     /locus_tag="KR257_001540"
     CDS             31622..32302
                     /locus_tag="KR257_001540"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003417129.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF881 domain-containing protein"
                     /protein_id="HBH0030249.1"
                     /translation="MKKQYVFIILASTILGILVGTIFRDYSNEETVYTSKDKSIRKEI
                     KMTRKSIKELTKEKDKLDKEINSMKQNQKNSEEISEIETLRDSLSYSDVKGSGIILSI
                     DAIDEKTGNIANSIDYNKILVKVINELKVNGGKYIEINGQRINQYSEVVLAGSHININ
                     GVPVAQPYEIKCIGDKEKLSNYVDKGSKYLDSIQTNYPMKISIKTEENISMKKMNIPN
                     KLKYIKGD"
     gene            32295..33674
                     /locus_tag="KR257_001541"
     CDS             32295..33674
                     /locus_tag="KR257_001541"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435622.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type II/IV secretion system protein"
                     /protein_id="HBH0030250.1"
                     /translation="MIKIILEESSLPMLIPEKLAKKYNVFPVEFQDDNLVVEIEDEDI
                     YALQDLRLATGKEIILKKEKKELISEKIEKYYNSFELDEDYAKKLFENLLEKAIKENA
                     SDIHIEPFKEHLIVRMRVDGELKEVSKFLVDVYPSLSTVIKLKASMDITEKRLPQDGR
                     VDIKLGGNLIDIRVSSIPTVYGEKIVLRILNRDTFLKDKLELGFSEEAIKSINRIINK
                     RAGILLVTGPTGSGKTTTVYSLLNDLKGINKNIMTIENPVEYKMDGISQIQVNSKVGL
                     SFDVGLRAILRQDPDIIMVGEIRDAETAKIAVRAAITGHLVISTLHTNDAVSSIARLL
                     EMQIPPYLLNASLIGVISQKLVRKVCNHCSHEIMIKDNFSGDVNTKVAVGCEKCNDKG
                     YFGRTAIYEILEINDDIKTCIRNMEDSSTIKDVAQNNGMITFEDSCKRLINEKITTLE
                     ECLVVNEMI"
     gene            33845..34930
                     /locus_tag="KR257_001542"
     CDS             33845..34930
                     /locus_tag="KR257_001542"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898464.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type II secretion system F family protein"
                     /protein_id="HBH0030251.1"
                     /translation="MRLSKNIFYNLEKFYLVLNRISDKEIRVICKEIGILLESGCEIT
                     KIFEIIESQSSKKAKNLLSIVSNHIQKGNSIAESFQITGIFSKFFISMIKAGETSGNL
                     DIIMSDLSNYYDKEYKLKMKIITISIYPIILIILSILSMLFIFVFVIPNFQVVFTNNG
                     IEPPLITRVLMGISTVVTNNLAYIIFSFILFSIGSIYFFITNDNIKKLINSLKFKIPF
                     IKKINQLVATTRFSRALSVLISSGIQIVEAIDMSASVIDNEFIYERLKISNNYIKKGN
                     SIGKSLNLANVFPKLFISMANTGEESGKLDKSLNVINKFYENELNNKIEQIMKFIEPM
                     LIVFMGLIIGTFILAMVVPMFDAITNF"
     gene            34984..35343
                     /locus_tag="KR257_001543"
     CDS             34984..35343
                     /locus_tag="KR257_001543"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891768.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type II secretion system protein"
                     /protein_id="HBH0030252.1"
                     /translation="MINLINKKRKGFTLVEMIVVVTILGVISSIALVKYSKVQESAKL
                     NADYTNAANIVTAASMAINDDEKTIDSLSVETLKEKGYLNTVPVPQSTSGKFELVIND
                     SGTDISVNINSKQFYPK"
     gene            35396..36268
                     /locus_tag="KR257_001544"
     CDS             35396..36268
                     /locus_tag="KR257_001544"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435627.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pilus assembly protein PilM"
                     /protein_id="HBH0030253.1"
                     /translation="MAIIKKILNLEINDDYIRLVFLRKSHKKVFIDKSIIKEINFDIK
                     NDSNSIEKIKYIEDVVRFVKEEIGKSKILYKNLYFNIQIQDIVIRNVEVLNTKKKRDI
                     LSMIEFEITQYIPININNYSIKYKVINSKNDKLNIQVILFPKSIIQLIKNISENLNMN
                     PKTININFDILQKLINLNLIENFSEEGVFIECKKSQLIINITKDKKIRETYLLSKEGK
                     SYEFIKRLLRDFKYVYYYGIENCFIEEYFKYTDKSIEVNPLRLKDKVKVENNFDADLE
                     DNRINYISNIGMII"
     gene            36269..36712
                     /locus_tag="KR257_001545"
     CDS             36269..36712
                     /locus_tag="KR257_001545"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728431.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0030254.1"
                     /translation="MKVDKTINFLNGFKKTKPCNKIYKIIIVLILTCILFKSFMYVKS
                     INELEDYISQNKLVDKSRHTLPTTDKTREKFSKIKLNEIKKIYETIGINIITKISIDK
                     NKLEIEGVCSDLDVLNNLRKIKYIKYYYIDSIVRDGEYYRFRIKS"
     gene            36727..37311
                     /locus_tag="KR257_001546"
     CDS             36727..37311
                     /locus_tag="KR257_001546"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891765.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0030255.1"
                     /translation="MRLNNREKNLLKILLILVIILASDIAVSYLEENLTSLKNEKQNI
                     INKINNQDNYQIKDNKHIDDKYIESVESNKNEELKNNFNNSFLDKKTNKDIVLLVENE
                     LRDIVNVEYINQESSLDNHNKKQVNLEIKVNGELANLLKLEGVMKKLRLNNKLEKIEI
                     NKLKVNNFDVQNIPNEYKQEKDNIVECKMTVRVI"
     gene            37564..38601
                     /locus_tag="KR257_001547"
     CDS             37564..38601
                     /locus_tag="KR257_001547"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009906384.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SEC-C domain-containing protein"
                     /protein_id="HBH0030256.1"
                     /translation="MLGRNELCPCGSGKKYKKCCLNKDIVSERACRKTELSQKQYTDL
                     YSKLYDYSRQDKFKEECEKAKEMFYIMQNDSVNEKFERFFNTYLIQDHIMENKKVMTV
                     GFLEENGANLSQSEVSILKSMFESYVSIYEVKEVSAGKIVLKDCLSGNELCTEDVKLL
                     RSFKIGSCMIARIVDIEGTNILIDITISISNEVKDIILKDIMNLFNQYQDVYKDMKSF
                     LIYHTHILYKYIQQLLDPSIAEYLKRERDKNDTKVNSENELAEEECKVLDTLKENVEK
                     ENIDACIEFWNEYKKNHENIKGAENGWAAAVEYYVKKEAGQPITQVQISKKYDISSST
                     LGKRYKDLKIS"
     gene            38682..39047
                     /locus_tag="KR257_001548"
     CDS             38682..39047
                     /locus_tag="KR257_001548"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003417144.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0030257.1"
                     /translation="MSLSLGNAIAVSTNFIKSNPAVPVYNGEEIYAVIYHIEIGYNNG
                     VSPDTKQYIIIDYKEFDLSMDKKNELINIAKEYCKSKGIVENENLEINLLDNEEAENF
                     LEKVFNNMKVIRGLITKKG"
     gene            39052..39369
                     /locus_tag="KR257_001549"
     CDS             39052..39369
                     /locus_tag="KR257_001549"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435631.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0030258.1"
                     /translation="MDYIGIENITPYENTYEFSVYEYDDEITLGSEKLYVCELRVVLI
                     KVNSLYVERLHKSVEAMVLVKNLKKDLDKTLVVNKIKNFVLDEIWVENLVKENIEVIF
                     VES"
     gene            39417..41021
                     /locus_tag="KR257_001550"
     CDS             39417..41021
                     /locus_tag="KR257_001550"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861896.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0030259.1"
                     /translation="MLRVSNVKLGIDKDISLLKDVILKKLKIKEKNLVKYSIYKESID
                     ARKKGKMEFVYSVDVEVKDENKILNSKIKDVTKIKEIRYVNVPVGDKKLKNNPLVIGS
                     GPAGLFAGLLLAQMGYEPIILERGLDVDSRTKDISDFWTTRKLKNNSNVQFGEGGAGT
                     FSDGKLTTRIKDIRCRKVLEELVQFGAPDEILYSHKPHVGTDILKNVVKNIRNEIISL
                     GGQVRFNSKVTDIVVSNDSIQSVIINDTEKIDTDTIILAVGHSARDTYEMLYSRGIKI
                     VQKPFAIGARVEHPQDLINKAQYKDFYNHPRLGAADYRLIEHVSNGRTAYTFCMCPGG
                     SVIASASNDFEIVTNGMSEHARDKINANSAFLVNVTPEDFKSDNPLAGVHFQQKYEKL
                     AFELGGKNYNAPVQLVGDFINNKTSLNLGSVEPSYRPGYTLTNLSECLPSFVTETMRE
                     AFISLDKKLNGFAMYDAVLTGVETRSSSPIRIVRDENTLESVSIKNLYPCGEGAGYAG
                     GIVTAAVDGIKCAEKIIQKYTNNTKI"
     gene            41145..42773
                     /locus_tag="KR257_001551"
     CDS             41145..42773
                     /locus_tag="KR257_001551"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891758.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Na/Pi cotransporter family protein"
                     /protein_id="HBH0030260.1"
                     /translation="MNIIISLMGGLGLFLYGMNLMGEGLQKSAGTKLKKIIKLLTSNL
                     FMGVLVGTGVTAVIQSSSATTVMVVGFVNAGIMTLKQAIGVIMGANIGTTVTAQLVSF
                     DLTGMAPVALGVGIILYLFGNKPRIKNIAEILIGFGILFTGMDFMKMAVEPLRDYQGF
                     TDLLVTFGRYPLLGLLLGFGITAIIQSSSASMGMLVALAAEGLVPLSAALPILYGQNI
                     GTCVTSLLSSIGANKNARRAAMMHLIFNVLGTVIFLIFLNKPVVSMVTSWDPSNVARQ
                     IANTHTLFNIISVLILLPFTSLIIKLAIKLVPDRAGDIDEDETKTIKYIDDRMIETPS
                     IALANTIKEALRMGEKAKESLNASMEALVEHSTEKIDKTYRRERLINDLQKAILNYLL
                     KLSKAALDDDSREVVDTLFNTVNDIERIGDHAKNIAELSQVAIDSNIYFSEEGQSELD
                     VMYNRVVSAYTYALESMRSDNVDLACKVIKIEEQVDIMEKSCRANHMYRLNNNLCSIE
                     NGVIYLDVISNLERISDHAVNIAQQVIAKRLGND"
     gene            43038..44387
                     /locus_tag="KR257_001552"
     CDS             43038..44387
                     /locus_tag="KR257_001552"
                     /EC_number="5.3.1.9"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435635.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glucose-6-phosphate isomerase"
                     /protein_id="HBH0030261.1"
                     /translation="MGKINFDYSKATEFFCQNEIDVMQPYVDVAHDMLHNKTGLGNTF
                     LGWIDLPKNYDKEEFDRIKKSADKIKSDSDVLLVIGIGGSYLGSRAAIDMVSHSFRNG
                     LKKEQRKAPEVYFVGHNISSTYIMDLLDIIEGKDISVNVISKSGTTTEPALAFRIFKD
                     YLEKKYGKEEARKRIYATTDASKGALRQLATEEGYETFVIPDDVGGRFSVLTAVGLLP
                     IAAAGLDIDAMMKGANDAREAFQNPDLKSNDSYRYAVARTILHRKGKDVELLVNYEPQ
                     LHYVSEWWKQLYGESEGKENKGLFPASVDFSTDLHSMGQYIQDGKRLLFETVLNVENC
                     KRNITISSEEVDLDGLNYLAGKTVDFVNHKAFEGTLLAHTDGKVPNLVINIPQLDEYN
                     FGYLVYFFEKACGISGYLLGVNPFDQPGVEAYKKNMFALLGKPGYEKEKEELEKRLK"
     gene            44543..45622
                     /locus_tag="KR257_001553"
     CDS             44543..45622
                     /locus_tag="KR257_001553"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435637.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="trypsin-like peptidase domain-containing
                     protein"
                     /protein_id="HBH0030262.1"
                     /translation="MSRRKKGISLVILVAIISSILSSFLTIILVKDNLVSKSTGSSTP
                     IVVNDDGKSQNIYQAVAEKATPSVVGITTTSVDTSNMFAIPTETQGVGTGIIVDSNGY
                     ILTNSHVISDGQATSVNVLFNDGSTTSGKVVWFDQQLDLAIVKVDKTGLTPAEFADSD
                     KVKVGDISIAIGNPLGLDFQKTVTQGIISGLDRTIQTEKTNMTGLLQTDASINAGNSG
                     GPLLNQKGQVIGINTAKASQAEGLGFAIPINTAKSIVEEVIKNGKYEKVTLGIKGTDV
                     SNYEAATGTKLSTDKGVYVAEVISGSSAEKAGVKVGDIITKVGDTDITGMNDLNKKLY
                     TFSKGASTKITVNRGGKAVTINVNF"
     gene            45967..46875
                     /locus_tag="KR257_001554"
     CDS             45967..46875
                     /locus_tag="KR257_001554"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728504.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycyl-radical enzyme activating protein"
                     /protein_id="HBH0030263.1"
                     /translation="MNPLVINLQKCSIHDGPGIRSTVFFKGCPLECVWCHNPESQTYT
                     KQVLYNEERCSKCEACINICPHKAIYKGETKICLDQDKCEFCETCLDYCVNNAREIVG
                     QEYSVRDLVKEIEKDRIFYEESGGGVTLSGGEVMAQDMDFICGVINMCKSKGIHVAID
                     TCGYAKSENYERVAKCADLFLYDIKLIDEDKHIKFTGKSNDLILKNVKILSELGANIN
                     IRIPLIVGVNVDDENLEVKKMIEFLKPLNIQAVSLLPYHNIGKHKYDKIYKKYEGEEL
                     QRPSEEKLEEIKRLFEASNFNTKIGG"
     gene            46880..49249
                     /locus_tag="KR257_001555"
     CDS             46880..49249
                     /locus_tag="KR257_001555"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728505.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycyl radical protein"
                     /protein_id="HBH0030264.1"
                     /translation="MARGTFERTKKLREESINAEPHISIERAVLMTEAYKKYEGSVEI
                     PVLRALSFKHYIENRTLSINDGELIVGEKGDSPNGAPTYPEICCHTMEDLEVMHNRDI
                     INFSVSEEARKIHKEEIIPFWKKRQTRDKIINAMTPEWLAAYEAGMFTEFMEQRAPGH
                     TVCGDTIYKKGFLDLKKDIEARLKELDFLNDLDAYNKKADLEAMAIACDAMVILGKRY
                     AEKARQMAEEETDEAKKQDLLLIAETCDVVPAHKPETYHQAIQMYWFVHIGVTTELNI
                     WDAFTPGRLDQHLNPFYERDVENGILDRDRAQELLECLWVKFNNQPAPPKVGITLKES
                     STYTDFANINTGGINPDGQDGVNEVSYIILDVMDEMKLIQPSSNVQISKKTPQKFLKR
                     ACEISRKGWGQPAFYNTEAIVQELMEAGKTIEDARLGGTSGCVETGCFGKEAYVLTGY
                     MNIPKILELTLNNGYDPISKKQIGIETGDPRNFQSYEELFEAFKKQLHYMIDIKIEGN
                     AVIENICAKHMPCPLMSTIVDDCIEKGKDYQRGGARYNTRYIQGVGIGTITDSLTAIK
                     YNVFDKKKFDMDTLLKALDANFEGYEAILNLVSNKTPKYGNDDDYADEIMQEIFNAYY
                     NEVTGRPTVCGGEYRVDMLPTTCHIYFGEIMGASPNGRLCAKPVSEGISPEKGGDTNG
                     PTAVIKSCAKMDHIKTGGTLLNQRFAPSVVQGEKGLDNMANLVRAYFNMDGHHIQFNV
                     FDKNVLLEAQKNPQDYKDLIVRVAGYSDHFNNLSRTLQDEIIGRTEQTF"
     gene            49574..50377
                     /gene="proC"
                     /locus_tag="KR257_001556"
     CDS             49574..50377
                     /gene="proC"
                     /locus_tag="KR257_001556"
                     /EC_number="1.5.1.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898446.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pyrroline-5-carboxylate reductase"
                     /protein_id="HBH0030265.1"
                     /translation="MKTLGFIGSGNMGSAMIGGIVQSGLVKAEDITVSDLSQVALDKV
                     KEEFGVNTTTDSKVAVTNSDVVIVALKPNICEKALTPLKELIDANKIIVSIAAGKTIE
                     SLESFIGSDKKIVRVMPNTPALVGEGMSALCKNSNVTDEELNMIKALFESFGEAEIVS
                     EYLMDTVTGISGSSPAYVFMFIEAMADAAVLAGMPRQQAYKFASQAVMGSAKMVLETG
                     KHPGELKDMVCSPAGTTIEAVKVLEEEGFRAAVIKSIVACIDKSKDMSK"
BASE COUNT        20577 a         5469 c         9088 g        15484 t
ORIGIN      
        1 tggagcaaca ggtccaacag gagcaacagg agcaacagga gtggcaggag caacaggagc
       61 aacaggtcca acaggagcaa caggagcaac aggagcagat ggagcaacag gtccaacagg
      121 agcaacagga gcaacagggg cagatggagc aacaggtcca acaggagcaa caggggcaac
      181 aggagttaca ggagcaacag gcccaacagg cccaacagga gcaacaggag caacaggagc
      241 aacaggtgct agtgcaataa taccttttgc atcaggtata ccactatcac ttacaactat
      301 agctggagga ttagtaggta cacctggatt tgttggattt ggtagttcgg ctccaggatt
      361 aagtatagtt ggtggagtaa tagaccttac aaacgcagca ggaacattga ctaactttgc
      421 attttcaatg ccaagagatg gaacaataac atctatttca gcatacttca gtacaacagc
      481 agcactttca cttgttggtt caacaattac aattacagca acactttacc aatctactgc
      541 accaaataac tcatttacag ctgtaccagg agcgacagtt acactagctc caccacttac
      601 aggtatatta tcagttggtt caatttctag tggaattgta acaggattaa atatagcagc
      661 aacagcacaa actcgattct tactagtatt tactgcaaca gcttcaggtc tttcattagt
      721 taatactgta gcaggatatg caagtgcagg aattgcaata aattagatta gataagaaaa
      781 ggcttctaat atcgtattga tattaggagc ttttttaaga atgattgatg aacatagttt
      841 taatattaat tagtgcgcat attataaaat actattatat aatataaaat aataacatta
      901 aattggaaat atagaattat ctaggggtga tactatgaaa aataagattg aaatatcaat
      961 gaacaacttt gtaaaaaatt atcataaatc aaataatata actacaaagt ggcaagaact
     1021 tttgtttgct tatgcatctg ctgaagatga tatgtttcag aagctaaaaa gtgttgtagg
     1081 aacatctcat gctatgccaa aagattttct ggaaaatgga aaaactataa ttacatattt
     1141 tatacctttt gatgaaagtg taaataatag taatattgga gggtttgaat gttctgaaat
     1201 atgggcaaga gcgtacatag aaactaatat gttgatttca aatttaaatg atttcttatg
     1261 tgaagaacta gagaagatag gggctaattc atatgctatt cctgggtcgt ataattttga
     1321 cagtgaaaaa ttggtaagtg actggtcaca aagacatgta gcattcatag caggtcttgg
     1381 aacttttggt ttaaataata tgcttattac agaaaaaggg tgttgtggaa gaataggaag
     1441 cataatcaca agtttagaat tagagccaac taaaagacca gaaaatgaat actgcttgta
     1501 taaacataat aatagttgca aaaaatgtgt caataaatgc gtgaaagaag ctttaaaaga
     1561 agatggattt aataggaata agtgttatga aatgtgtatg ataaatgaaa aaaaatacac
     1621 ttatataggt ggatgtgata tttgtggaaa gtgtatagtt ggagttcctt gttcagtaat
     1681 aaacccatca agataatgga tttaagttga ctaataattt taaagatagt ttataatgaa
     1741 aaaattttag ttatcaaaat aaatataata taaaaactaa ataaatgtgt ttaaaaaatg
     1801 gataaataat ttgtgttgat tgacaaccag ttatactgtt gatagactta tatgtatcgc
     1861 tgtgatatat aaggagggtt gagattttat gtttgattta atctttattt ttgcatagca
     1921 agggctattg caactatgaa atttaatata taaatagccc tttgctattc ctaatgaaaa
     1981 attactattt aataggagag caaaatgagc tataaaaaag caatacatat attaccagaa
     2041 gaattacttg aattaataca ggaatatgta gatggtgaat gtatctatat tcctagaaaa
     2101 tctaataata aaaaagaatg gggaagtaat acacctactc gtgaggagtt gtcaattaga
     2161 aatatgcaga tttacgaaga ctatcaagtt ggatatgatt tgcaatattt atcggaaaag
     2221 tattatttat ctttgaaaag tatccaaaga attgtattac aagaaaaaag aaaagatatc
     2281 taaggatgag ccagtatagt tttataatta tactggctca ttttcttttg ataaaagtgt
     2341 ttgaggtata gtttctttta agtggatgat ataatttaag taatttcaat aacttataca
     2401 gtagctaaca aagctggttg taaagtatct aataagaagt agtagctttt tatatgtttg
     2461 aaattaaaat ttattaaaat taggaggtct tgttttgaaa aaaatacttg attatattcc
     2521 accttttcat aactttctat taatttagta atcttataga aaggaaattg catttatgaa
     2581 aaaaattact tgggaggtgg aatatatctc ccagttacct gtaattaggt attgtaaaaa
     2641 atgtggaaaa aagactgaat atatttgttc aggtttattt agggttaatg ctcaacataa
     2701 atatttggat atatggttaa tatacaagtg ttcaaattgt gattcaacat ggaactcaac
     2761 tatatattct cgtgttaatc caaaaagctt aaatccagaa atactagaac aattccatac
     2821 aaatgattat aatcttgtta agcaatatgc tatgaatatg gaacttttac atagaaatgg
     2881 agcagaagtt ggtattccag agtataaaat agtaggacaa gaaattaata ttaatgacct
     2941 tacacaagtt catattatta gtaaatatcc atgtcagtta aaggtatcaa cattattacg
     3001 tgagaaacta ggtttatcta ggaaggtatt tgacgaaatg ttggattgtg ggattattag
     3061 aagtaactca ggagttgatt taaagaaagg taaattaaat tatgaaatta tgttagatat
     3121 aggcaaggag aagcaaaagt cttcaaattg attagaataa ctaacttaat atattttcag
     3181 gaacatcatt taaaaaaata gtgactttaa aaaatttaaa gccactattt tttaatatgt
     3241 tttatctata taactattat ttttctaggt tttttaatat ttcgtaatag tgtgttgtgg
     3301 ctatttcact tgactcgcct tttttacaaa aagataattt agatagtttt ggaactacac
     3361 gttcaacgac aattttatta cctatcattt tagattcaag tatcttcaat gcttctaaaa
     3421 atctcttatc cttttttgca cgattataaa atgataaaac gtagacataa aggaataggt
     3481 tataattacg gaaaggatat tcaacttgca taaataatgt gccaattcca tagtgacaag
     3541 ggccgattgg ttttttaata gtccaatggt caagtagaaa atctacagct ttgtcaagtt
     3601 ttgattcttt atttagataa ttactaaaac ggaatgcatt taatatatta agagttggta
     3661 gtggatttga gtattcagtt tctggacctc gaccaaaact aaatttattg caacgccacc
     3721 caccatcagt atactgtgta tctaaaaaat gttgaaacgt tttttgcatt ctaatgtcag
     3781 atgcatatcc catatgacag agtacgttag cagcatttgc agtatgacaa gggtaaatac
     3841 ctccatttgg atatagtttg aaacgtccat cttctcgcca tgtgctaaat atcaggtcag
     3901 cacattcttt aagtaaagta tcatcagggt tcacacctaa ttctaataga taaagtacac
     3961 tatcaagagt agagaaagga gaacctttta ttaaacgctt atcaggtgta gtccaatagt
     4021 ctgcaccatt atcatacctg tgtgataata ttatttcaat atctgataaa gattgatttt
     4081 ctacattcat tttttactcc atttcatatt atattctatt aaatctatca aaaactttat
     4141 tataatatta tttatattta taattgattt attttattta aaattgcatt tatagctgta
     4201 tcaggaacaa ctgctaaatc ttctgcattg aagtaataaa ctatattaga atcaaataat
     4261 atatttgaat ttggaggaaa ttcatcatct ccaaaccaaa gtataaatac catagatgta
     4321 ttacccatat atgtaaacct ataagctaaa tctcccatgt ttactttttc agctccaatt
     4381 ttctccataa ctaacttata tttgtctatt tgagatgtaa aaacttctga aagcctatat
     4441 agagtcctgt ttaaaaaatt tggataataa acattgcctc ctggtatttc tttaaaagtt
     4501 acatatttat tagttctagg aataccttta gcattgatta aatatctaac tatcaagatt
     4561 ttaagctcaa agttattgca aaggctacca ttactattcc aaacttctcc acttggatag
     4621 tctataatat attgtctatc aaaaaaattg agtgtgaatc tatttaaatc attattgaaa
     4681 ggtatattac ttaaattact aattgtatga gggtctaatt ctttgagttt ttttcgaaca
     4741 tagtcaaatg gaacattata attatttttt gttatctttt catccataat tttttcctcc
     4801 aatttaaaca attaaaagta tatttataaa aagttttctt attattaatt ttattatata
     4861 ttcaaaatat tacaataata aattgttaaa taaattttta tatttaagta aatacgtgta
     4921 aaatgaatat aaagtttttg aaatataaag tttttgtatc taaaatattt tatttgtaaa
     4981 atagtaatta attattgtaa gctataatat gagagtatta tggttaatgt gaattttaaa
     5041 gatattatta aatatataaa ttagaatact attaaacgga taaatggagg agttattatg
     5101 tctaagatat tagtagtaga tgatgagtta gatatgttaa agttgattga aaatgtgttg
     5161 aaaagagatg gacatgaagt aaaggtaatt agtgatgtag aaaaagctat gaacatggat
     5221 tttaattatt ttaatctaat aatattagat gttatgatgc ctaagatgga tggttttgaa
     5281 gtatgtaaaa ctataagaaa taaggttgat tgtccaatac tgtttttgac agcaaaaaat
     5341 atggaaagtg atattatgta cggtcttggt ataggtgcag atgactatat aaccaaacct
     5401 tttggtgtag gagaattaag ggctaggata actgctcatt taaggcgaga aagtagagaa
     5461 aaaaagaatt tattaactat ctcaaatgtt caatttaact ttttaggcaa agaagtttca
     5521 attgatggta aaaaaattaa ttttactaaa agtgaatatc taatatgtga atttctagca
     5581 aaaaataagg gacaagtatt ttcaaaagaa agaatatatg agtcggtata tggttttgat
     5641 ggagaaagtg atataagtac tatcacagag catataaaaa atatacgaag caaattaaaa
     5701 caatatgata tttatacaat agaaactgta tgggggatag ggtataaatg ggtgtaataa
     5761 gtataagtgt tgtttagtga aaatattata tatatctaca aaatgtttgt aaaatattaa
     5821 tctatatatt aaaatttaat ttatagatta atattttttg taaatgacaa aattgtaagg
     5881 tattttgtta taaaatatta agattcatag tgtatactaa taatatagta tttagtataa
     5941 atcttgagca aaggatggtt atttctaatg gatagactaa agaatattag aaagagttta
     6001 ctacagtata catttttatt tttgttaata ggtataacaa tttacctagt gtttaaaaca
     6061 ttggatatta aaatgctatc aaatgttatg gttatggtag ataagaagtt tttattcata
     6121 ggtgctttgg caataatgtg tcacataatg cttgaaggag tagtaatgaa gataattata
     6181 gaaagcactc acaaagttaa tattagattt attggtttta agctagccat tatgggattt
     6241 tattataatt taataactcc ttttgcttca ggaagccaac cagtacagat atatgtactt
     6301 aaaaaatgta aaatgccact tagtaaggca agtgcagttg ttaccaataa gtctattatc
     6361 ttccaaatag tagttacttt ttattgtaca atacttgttt taatgaattt tgctatgtta
     6421 gaaaaacaaa tgaaaatgat tatgcctcta gtgtttctag ggatagccat taattcattt
     6481 gtcttaatta tgataatatt agttatttta aatcctaaaa aaataaaata ttttatgaga
     6541 attactataa agcatttatc aaaaattaag tttttaaaat ttttagataa taagattgaa
     6601 tccatagaaa gttttataga tgattatagt aaagcaataa atttttttgc aaagaataaa
     6661 aaggtattaa tttcaactat aatagtaact tttattcaat taagtgctta ctttagtgtt
     6721 tcattttgga tatataaagc atttaattta caaggttata gctatattta tatactgaca
     6781 ttacaagcat ttttatatat ggcaatatct ccaataccaa cacctgggaa tgtaggagct
     6841 aatgaattag cctttttcac tatattcaaa tcagtattcc ctcaaccttt gatgggatat
     6901 gcagtatttt tatatggtgg atttatgtac tatttgattc tgattggaag tggaatattt
     6961 actgtaatta ctcactatag aatgaaaaat agaattggca gaaatattgt tttaagtgaa
     7021 aactaaataa gtttaaagaa tatatattga gtatattaaa aaatatgtca taagaactag
     7081 aatattttaa ttaaatggtt gaaatataaa gattattatg acatattttt tttgaaattt
     7141 aagaggaatt gtgagaaaat tgttgaattt aatagatagt attgcaaaat atttatgatt
     7201 ttgcatatta taaaaacact cattatcttt aagataaatt ttacttatca ggggataaat
     7261 ctaagggggg aattgtatgg agaaaaaaat tttaacagtt tgtccatact gtggagctgg
     7321 atgccaatta tatctagtag taaaagataa taagatatta agagctgaac cggctaatgg
     7381 tagaacaaat caagaaagtt tgtgtttaaa aggtcgttat ggatgggatt ttctaaatga
     7441 ccctaaaatt ctaacaccta ggctaaaaaa gccaatgata agaaaacaag gtgtactaga
     7501 agaggttgaa tgggatgagg ctataaacta tacagcttca agactaaatg aaattaaaga
     7561 aaaatatggt cctgattcta ttatgggaac aggttctgca agaggacctg gtaatgaagc
     7621 aaactatata atgcaaaaat ttatgagagc tacaatagga actaataatg ttgaccattg
     7681 tgctcgtgtc tgacatgcac catctgtagc cggtctggct tactcattag gtagtggtgc
     7741 aatgtctaat tctataccag agatagaaaa tgcagatgtt ttatttatat ttggatataa
     7801 tggagcagat tcacatccaa tagtggcaaa tagaatagta aaagctaaaa aaaatggtgc
     7861 taaattaatt gttactgacc ctagagtaac tgaatctgca agaattgctg atatacatct
     7921 acctataaaa ggtggaacaa acatggtttt agtaaatgct tttggaaatg tattaataga
     7981 agaaggtctt tacaataaag aatttgttca aaatcataca caaggatttg atgagtataa
     8041 agaaattgtt aaaccatata cagctaaata tgctgaaaag attacaggaa tcccagaaga
     8101 gcttataaga aaagctatga gagaatatgc aaaaggtaaa aaagctatga tactttatgg
     8161 aatgggtgtc tgtcaatttg gtcaagctgt tgatgtagtt aagggacttg catcaattgc
     8221 tctacttaca ggtaattttg gtagagaaag cgttggaata ggacctgtac gtggacaaaa
     8281 taatgttcaa ggagcttgtg atatgggagc tcttcctaat gtatatcctg gctatcaaaa
     8341 tgtaactgat gataagataa gagaaaagtt tgaaaaagct tggggggtaa aattatctcc
     8401 taataatggt tatagtttaa ctcaagttcc aaatttagta ctaaaagaga aaaagcttaa
     8461 agcttattat atatttggag aagacccagt gcaaagtgac ccagatgcat cagaagttag
     8521 agaagcatta gatgaattgg aatttgtcat tgttcaagat atatttatga ataagacagc
     8581 acttcacgct gatgttatac ttccagctac ttcttgggga gaacatgagg gagtatatac
     8641 atgtgcagat agaggattcc aattgatgag aaaagctata gagccacaag gagatgtaaa
     8701 accagactgg caaattataa gcgaaatttc tacagcaatg ggatatccta tgaattataa
     8761 aaatactaag gaaatatggg acgaacttag acaattatgt ccaagtttct taggtgctac
     8821 ttatgaaaag atagaaactc aaggatgcgt tcaatggcct tgtaagagtg aaagtatgga
     8881 agataaagga actatgtatc tgtatgaagg tcaaaagttt tctactccta atggtaaagg
     8941 taatttgttc gctgctgaat ggagaccccc tatggaagtt gaagatgatg aatacccatt
     9001 tagtttatgt actgtaagag aagttggaca ctattcagta agaacaatga ctggtaattg
     9061 tagaacactt agttcattag aagatgaacc aggacgtgtt caaataaatt ctaatgatgc
     9121 tgaaaaatta ggaattgaag atgatgaatt agttagaatt agttcaagaa gaggaagtgt
     9181 aataacaaga gcaacagtta ctgatagagt taaggaaggt gcaacatata tgacttatca
     9241 gtggtgggtt ggagcttgca atgaacttac aatagcaaat ttagatccta tatctaaaac
     9301 accagagtat aaatattgtg ctgttaaact tgaaaaactt gaagaccaag aattagcaga
     9361 aaaatgtgta agagaagagt atcaaagttt gaaagacaaa atgacagcta caaatatcta
     9421 atgatttatt agatttaaga tttataaaag gcagaaaggc taatatttta tgaacaatat
     9481 atactcaaaa actaaattac aagaaaatag taaggataaa gtttttgaaa atagttatag
     9541 tctagtggac tacaaatatt taaattcttt taatgtagaa gtaagcaaaa taaatgaaca
     9601 tgaagtatca atagataatg aagaaataat tgcagaatat ccacttagtt ttattttaaa
     9661 tgataaatat ataaatacat ttttatgtac cccatataat ttagaggaac ttatagtagg
     9721 attcttgaaa acaaaaggat acatagaaaa caaaaaaagc ttattaaaat ttgagataaa
     9781 tgagagtgaa cgttttgcaa aagtaactat tcaagagaaa caaaaaaatc aagatgagca
     9841 aattatattt ttaaattcac tagactatat aacatgtgct cctgtaaaga gcaatataaa
     9901 aataaattat gatacgattt acagtataat ggatagaaat ttaaattcat cagaattatt
     9961 taaaaatact ggtggggtac atagcgtatc tgtatttaat tttgataaaa aaatagtcac
    10021 ttgtgaagat gtagcaaggc ataatgcaat ggataaggct attggatttt gtgttttaaa
    10081 tgacataaca ttaaaagata aaattgtggc tgtaagtgga agaatatcat tggaaatgat
    10141 attaaaagca gctatgactc aaattcctat tgtagtatca aaatcagcac cgactaattt
    10201 atcaatagag ctttctaaaa aattaaatat aacgcttatt ggatttgtaa gaggaagacg
    10261 gatgaatatt tatgcaaatc cacagagagt tatcaaaaag tgagaatgaa tatatgtgta
    10321 ctaaaaaaga agagcaaaga tattcaaagt gtgaaatctg tggagtatta attgatgata
    10381 ctgataaggt gtataataac acatacaatt tgtgcaaaaa atgtaaacga aatataagta
    10441 ctgagaaaat agtgaaatat ataaatatat atgatgaaag taagtagaca tatgatgaaa
    10501 ataactagag ggttggaaat atacaaattg aaaggtggga taatatgaaa aataaaatag
    10561 gctcttttgt aatagcagac ccaaacaaat gtacaggttg tagagcttgt gaagtagctt
    10621 gttttacaat gcataatcag cataataatg tgggttatac agttggaaca gttgatatac
    10681 ctgttatacc tagactttac ttagtaaaag gtgacaattt ctgtatgcca atacagtgta
    10741 gacagtgtga agatgctcct tgtttaaact catgtccaca aaaagctata gttaaagaaa
    10801 acaatattat gtctgtaaat gaagaaaagt gtataggatg taaaacttgt ctgctagcat
    10861 gtccttttgg agctatagac ttacttccac aatatgaaga tggtaaagaa gtagaacaag
    10921 taattttaga tgaaaataag aagatagctt ataaatgtga cttatgtaaa gacaatgaaa
    10981 aaatagcttg tataagtgca tgtcctcagg aagcattaaa acttgttact ccaatagatg
    11041 acaaaaaagc taagaataga caagctgcac ttagtttatt gttaacaaat aaataaagga
    11101 tacaggggta ggtgacgttt atgataataa atatagataa ggatttatgt actggatgta
    11161 gagaatgttc aaaggtctgt ccagtaaatg ctattgaagg tgaagaggga aagccacaag
    11221 agataaattt agatagatgt gttatgtgcg gtcaatgtgt tcaaacttgt aaatcttatg
    11281 cttcagttat agatgaagga tttgagtttt tacaagagaa aaaacaagaa agagagatac
    11341 cagagtctat aaatgaacct atatttgcag catacaatgt atgtgatata gataaggtga
    11401 agaaagcttt aagtgaccca aatgtattca ctatggtcca atgtgcacca gcagttagag
    11461 ttgctttagg agaagatttc ggatattatt taggatactt aggtgctggg aaaatggcag
    11521 cagcacttag agctttaaat tttgatagag tctacgatac taattttgca gcagatttaa
    11581 ctataatgga agaaggtagt gaattaatta aaagagtgac agaaggtgga actcttccaa
    11641 tgtttacatc ttgttgtcca gcttgggtaa aattcatgga aaaaaattat cctaaattaa
    11701 ctaatcattt atcttcttgt aaatcacctc agcagatggg tggtgcaata tttaaaactt
    11761 atggtgcaga gataaataat gtagatgcat caaagatatt tagtgtttct ataatgccat
    11821 gtacatgtaa aaaatatgaa tgtgatagag aagaaatgga ttctagtgga tatagagatg
    11881 tagatgtagt attaactact agagaactag cttatttaat aaaagacatg ggaattgatt
    11941 ttaaaaattt aagagaagaa aaatttgata gtcctttagg tagttatagt ggagctggaa
    12001 ctatctttgg tgttactggt ggggttatgg aagctgctat aagaacagga tatgagctta
    12061 taactggaga aagtattcct gatgtagaag taaaacaagt aagaggagaa aatggtttta
    12121 gaaagtcaac tattaaaata ggagacttag acttaagagt tggagtagta agtggattaa
    12181 aaaatgtaat accagtgctt gaagacttgg aaaaaggaaa attagatgta gattttattg
    12241 aagttatgac ttgtcctgtt gggtgtgtaa gtggtggagg tcaaccaaaa attttactag
    12301 aagaatataa ggaattggct tatgaaaata gaacaaaagc aacatacgtg catgatgaac
    12361 atttagcaat tagaaaatct catgagaatc ctgatattaa aaaactgtat gatgaatatc
    12421 tggtagaacc attaggagaa aaatctcatc atctattaca cactacatat tgtataggaa
    12481 aggaagtggc taagtgatga actattttgt tatagcagac cctgataaat gcataggatg
    12541 tagaacttgt atgataggat gtgtagttgc acattcagat gaagatattt tttaccaaaa
    12601 tctagatgaa ataaatttta atccaaaact ttctgtcata aagacaaaag aagtaagtgc
    12661 tccaatacag tgtagacatt gtgaagatgc tccttgtgca aaggcatgtc caaatggtgg
    12721 tatagttagg gttgggaaca caataaaaat aaatgaagaa aattgtatag gatgtaagac
    12781 ttgtatgtta gcatgtccta taggtgcaat agacatagtt acattaaaag atgtagatga
    12841 aggaaagctt tgctttagag aaagaatgac agcaaataag tgtgattttt gtatagaatc
    12901 gccagaaggg cctgcatgtg taaatgtttg tccaactaag gcatttacta tagttaagga
    12961 tgaggatata gatagtaaag ttaaaaataa gagaaaatta gctatattgt aatataaaaa
    13021 agatggagtt ttatttatga ttaaaagctc catctttttt attataatat ttatatatct
    13081 aaaaatcaat tattgcatta gtttatctaa tctttcttta ttcaattttt tcattcctat
    13141 agaagttata ataagtaaag tataggcaat tataactgat aaaattataa tagaccaaga
    13201 aaatctgtat ccaaaattat caactaacaa tccaaataat gttgaaccta atgcaaatcc
    13261 cactgcaaaa attaattgta cgattccata tatgctacca aactcctttt gaccaaagaa
    13321 agagccagtt aaataagcag gaccaatcat ataagcaaat acagaaagac ctttcaaaat
    13381 ggcaaataca aatgcaaaag tagaagattt atctaccaat agtaatgata aagttgctat
    13441 aagaaccaat acaaaagata taataagtgg ctttgtttga ccgaatttat caaacaataa
    13501 tcctccaaat aaattaccaa tgagagcaaa taaagcaaat gtggagccta ctgttcctat
    13561 tagaatagga tttagataat ttctaagata agttggatat tgtacggata atgatgaaac
    13621 atatatacca acaaatataa atccaatagt cataatccaa aaatatttaa tttttttagc
    13681 ttcttttaat gtataacccc atactgaagg agaaattgta tcagatgctt tctctttttt
    13741 acctttagat tttacctttt cattaatatc tttaggcatc ctgagtatga ataatattac
    13801 aggtatacca actattaatg ctataattcc aaatattaga taagaacgac tgtatccttg
    13861 agttgctaat aagcgaactg caagtggttg tagaaatata ctaccaatag aaccaccagc
    13921 aaaagcaaag cccaaagctt ttcctttgct ttcttcatca aaccaagcac ttattaaaac
    13981 aggtattcct atagcagata taattgtagc gccaatttga acaatacatg atacagtgta
    14041 aaattgccat agttcagtac atatagaaaa agtagcaaaa gcaatactag aaattataca
    14101 acctaataaa tatagtatct taatattgac tttagaaaat aatacaccta taaaaggtga
    14161 tgcaattgct gaggcaatag taccaatagt gaatattaga gaaaaagaag ctaaactaaa
    14221 gccttctcct tctacaacat aacttataaa ttgaggctgt atacttgcta caatactaaa
    14281 tggaacagct tgtatcaaca tacaaccaag tactataacc caagcatttg aaaagttttt
    14341 aatgctaaat ttattgttta gtaatgtatt catggtatct ctcctttagg ttatgatttg
    14401 tagatattaa tctaattatt ctaattttat atattagttt tggatagccc aactatttaa
    14461 atataatttg ggtattaata taaaaattaa ctataaaaat tgattatttt aaatgtatgg
    14521 ggtaaattaa agtatataaa taaatgaaag gatggataaa atgtcatttg aaaaaataaa
    14581 taataataac ctagataaaa tacacaacag gaagtgtatt atgcttgtaa actttaataa
    14641 aaaagaatta tcattaatta aaaacgtaag taactttgct ggaataagag accatatcat
    14701 cttaagtgat aaaaatggag agaatataat aagagacatt ttagatggaa atatatcaaa
    14761 tgaatgtgaa aatgggatta agagtaagtc tgtaatattt aataacactc caagcacaca
    14821 agtaaatgca tttttagaag ggctaaaaaa agtgagaata aatagacctt ttacagctat
    14881 ggtaacagag acatctattg attggacatt gaataattta atagaaaatt tagttcaaga
    14941 acgtaatgct atgtctttag gaaaaacaat tgaacataag taaatttaag atatcttata
    15001 gtaattttaa ctaatgtaca ttgagtatca tattatattt tagaatataa aattttaaat
    15061 gtgggtagat ggaggagatt tgagatgaaa gttttattta caataaatta tggaaaagaa
    15121 aaatttgata aaataagaga attaggctat gatgtcatac attactctga agatagtatt
    15181 gaaaataatg aggatgtaaa tacagcagat gtactagtta catacaatcc atttgagaga
    15241 ttagatattt ctaagatgaa aaatttacaa tatatacaga caactagtgt aggtatagac
    15301 caacttccaa aagaagaggt attgaagaga aatattaaga tagctaataa tagaggcgga
    15361 tatagtgtac ctattggtga aagtattgta ttgtatattt tagaaatata taaaaatagt
    15421 gcaaaatttt ttaaacaaca acaaaataaa gaatggaaga tggatttttc tgtatcagaa
    15481 ttgtatggac aaagagttgg atttttagga acaggtacta tatcttcaga agcagcaaaa
    15541 agattaaaag cttttggtgt agaaatatgg ggtgtcaata ctgatggaag tagtaaaaaa
    15601 tactttgata agtgttttgc tactgaagat atgaatattg tatttgaaga atgtgatata
    15661 gtagttgtag caatgccttc tacaaaaagt acagatggaa tagtaaacaa agatatgttt
    15721 aaacttatga aagatggttc tgtatttata aatgtaggta gaggaaatac agttaatcag
    15781 aaagatttag aagaatgtgt agagaaattt agaggggtag cattagacgt atttgaaagt
    15841 gaacctttaa acaaggacaa taagttgtgg gagtgcgaaa atgtcatagt aactcctcat
    15901 aattcttggg tgtcagataa aaacaaagag agaacattta atatggttta taataatttg
    15961 aaacactata taatggagaa taaacctgta gataatgttg tagacatatc aagaggctat
    16021 taaaaataaa aaattttgat aaaaataaaa actcttatta gtcgtattaa agatactaat
    16081 aagagttttt tttgtaataa atttaaagcc caaaaagtga tatactaaaa aatatataaa
    16141 taggagataa ttaattatag ggaaatttca aaataattta attttaaaaa tatgaagagg
    16201 tgcaaaaagt gagcgtaaaa gatgaaatta ataaacttat agagacaata aactaccata
    16261 atgaaaggta ttataatcaa gatagcccag aaatatcaga ttatgaatac gataagttaa
    16321 tgaaggagtt aatttcttta gaagaagaac atccagaact aaagagaatt gattctccaa
    16381 caaatagggt aggaggtaag ccattagata agttcaatca aattgtacat aaaactccta
    16441 tgttgagttt atcaaatgct ttttcagagc aagatttgag agattttgat aagagagttc
    16501 aagaatatgt gggagaaaat gttgaatatg ttgttgaatt taaaatagat ggtctttctg
    16561 taggtctaac ttataacaat ggagagtttg aaaaaggagc aactagagga gatggagttg
    16621 taggagaaga tatttctcaa aacttaatga cagtaaaaag catacctctt aagataaatg
    16681 ataaaaaaga actaatagtt agaggagaag tatatatatc aaaagataat tttagaaaag
    16741 taaatgaaca acaagaagaa caagaacagc cattatttgc taatccaagg aatcttgcag
    16801 ctggttcatt gagacaatta gacccaaaac taacagcaaa gagaccatta gatatatttg
    16861 tatttaatat ggaaaatata gaagaatacg atttagaaag tcacagtgaa tcactagagt
    16921 acttagaaaa actaggattt tcagtaagtc agagttataa agtttgtaaa agtatagatg
    16981 aagttattga gcatattgaa tactggacag ataacagggg taatttagac tacgaaatag
    17041 atggtatggt aataaaagta aacaatataa aacaaagaga cgaaatggga tatacagcca
    17101 aaagtcctag atgggcaatt gcatataaat tcccagcaga aaagaagaaa actaaaatag
    17161 tagatataat agtagaagtt gggagaactg gtacaataac accttcagca attcttgaac
    17221 cagtcagact tgcaggtact actgtaagta gagctacact tcacaatgaa gattatataa
    17281 gagaaaaaga tataaaaata aatgatacag tattagttca aaaagcaggg gacataatac
    17341 ctcaagtttt agaagttata aaagaagaac gtactggaga tgaaatagat tttaaaatgc
    17401 cagaaaagtg tccagtttgt tcagagccaa caataagatt agaaggagaa gctgctgtaa
    17461 aatgtatcaa tatgtcttgc ccagcccaaa taagaagggg aattatacac tttgtgtcaa
    17521 gggatgcaat gaatatagat ggattgggag aatctataat tacactgcta ttaaatgaaa
    17581 aaattattca agatgtatct gatttatatt atataaaaaa ggaagatgta gtcgacctag
    17641 agagaatggg cgaaaaatct gctgacaatt taataaattc aattgaaaaa tcaaaagaaa
    17701 atgatttatg gagacttata aatggattag gtattaaatt tataggagtt aaagcagcta
    17761 agatacttgc atataacttt aaggatttag atgaagtaat ttctgcaact agtgagcaac
    17821 tagaagaatt agaggaattt ggaagtataa tggcaaacag cgttgtcgag ttttttaagg
    17881 aagacaaaaa tatgaacgtt ataaacaagt taaaaaatgt aggagtaaat acaaaatcat
    17941 tggataatac aggtgaaaaa gtagaaaaaa tatttgaagg gatgaaaatc gtattgactg
    18001 gtacacttcc tacattaaaa agaaatgatg caaaagatat gatagaaaaa agaggtggaa
    18061 aagctacatc tagtgttagt aaatcgacaa catttgtttt ggcaggtgaa gaagctggtt
    18121 ctaaacttac taaagcaaat gatttaggaa ttaaagttat agatgaagag agatttttag
    18181 aattattaaa gttatcatcg aaagatgaag taaaagctgt attagagagt taaaaagtcg
    18241 cttaatttag tagaaaacta ctataattaa tgatagaata gttcagtaag ctaataagat
    18301 tacgaaaaat gacaataatt aatatttgac aaaattaaaa attataaaaa taaatttata
    18361 aaaaataaaa aatatgagaa aggatataaa aaatgaccag aagttatgat agaagtaacg
    18421 aacagataag acctgtaaag ataactagag attatacaaa gtatgcagaa ggttctgttc
    18481 ttatagaaat gggagagaca aaggttatat gcactgcatc agtggaagaa aaagttcctc
    18541 cttttttaag aaatagtggt actggatgga taaatgctga atattctatg ctaccaagag
    18601 caacacaaca aagaaagata agagatgcat ctaggggaaa aattgatgga agaacacaag
    18661 aaatacagag gttaatagga agagcaataa ggtctgttgt agacttgaat aaattaggag
    18721 aaagaactat ttgggtagat tgtgatgtga ttcaggcaga tggtggaact agaactgcat
    18781 ctataacagg ggcatttgta gcagttgcag aagcaatata taaattatat aaagcaaaga
    18841 taataaaaga gatgccaata acaaattttg tgtctgcaat tagtgttggt attgtaaatg
    18901 gaatacacat gctagattta tgttatgaag aagattctaa agcacaggta gatatgaata
    18961 taataatgac tgataagtgt gagtttgtag aagtacaggg gacaggagaa gagaaacctt
    19021 tttcgagagc agatttaaat ttattgttag agttaggtga aaaagggaat aaagaattaa
    19081 taaggcttca aagagaagct ttaggtgaaa tatcagatga gatattgggt atggattatg
    19141 gtaatgaagt agtgattgct actaataatg ctcataagct agaagaaata ggtgaaatct
    19201 taaaagattt tgaatataaa gtgtactctt taaaagatgt tgatttagca ggtatagaga
    19261 tagtagaaga tggaaaaaca tttgagcata atgcgttgat aaaagctaga acaatagcaa
    19321 aaaagactaa acttatagca atatcagatg attctggctt agaagtagat gctttaggca
    19381 aaaaacctgg tgtttattca gctagatatg caggagaaca tgcaacagat gaagaaaata
    19441 gaaaaaaact gttaaaagct atgcaaaata taccaatgag caaaagaaat gcaagattcg
    19501 tctctgcaat agcagtagtt tttcctgatg gaaaagaatt tgtagtaaga ggaatttgtg
    19561 aaggaatgat aggatttgaa gaaaaaggta aaaatggttt tggatatgat agcttattta
    19621 tagtaaaagg atatgataag acttttggtg aaatacctag tgttataaaa aattcaatca
    19681 gtcatagagc aaacgcacta aaacttatga aacaagagtt tataaaaagg gtagtgaagt
    19741 aatgaaaata ggcatagtaa gcgacacaca tatgatgatt aaaaatatgg aaaaaacaat
    19801 accatatttg aaagaatgtg acctaataat tcatgcagga gataacttta ctgattcaag
    19861 atatattcat agcatgacta atgtaggtat tattgcagtt aaaggtaatt gtgactttga
    19921 tgctgttgag gaagaagttg tctttgaagt ggcaaataaa accatattct tatgccatgg
    19981 agataagtat ggcgtaaaat atggaactca tatgttagaa aaaaaggcaa ctgaagttga
    20041 tgctgatata gttatatttg gccataccca taccccattt agagaaatta aagatggtgt
    20101 actttacata aatcctggaa gcacttcact tccaagagga gtatcgtata aaagttttgt
    20161 cattatggat atagaagaag atgacataaa aattgaagaa atacgcatat aaaggtgtat
    20221 ttatctaaaa aaatggcaaa aaacgctcaa aaaattaaat tttatcaaat aagtacaacg
    20281 atattaatgg aacacttgta aataaaaaaa cttatgtgat ataattaagt ggttgaatta
    20341 taaatagaat gaattataat accgttatcg ggtattacat aaatatcact aggaggatta
    20401 gaaggatgaa agcagaacta attaaaaaag agggtaataa agttacttta aaaataacag
    20461 tagataacaa taaatttgaa gcagcagtaa ataaggctta taataaaagc agaaataaat
    20521 acaatatacc tggatttaga aaaggtaaag ctccaagaat tgttatagag actcaatacg
    20581 gaaaaggtat attctacaat gatgctatag aaatattatt cccagaagtt tatccagaag
    20641 ctatcaagga attagacata gacccaatag acaatccaga tttagatata gaagaaataa
    20701 gtaaagacaa tgggttggtt atggttctta atgtagaagt taaaccagag tttgaattag
    20761 gaaactacaa gggtatagaa atagctaagg ttgagaatac tgtaagtgac gaaaatgttg
    20821 atgctaaact acaagaaatg gttgaaaaaa atgccagatt agtaagtgta gaagacaaag
    20881 ctttagaaga tggagataca gctataatag acttcgaagg ttttgaaaat ggtgtagctt
    20941 ttgatggtgg taaaggtgaa aattataact tagttatagg ttcaaacaca tttataccag
    21001 gatttgaaga acaattagta ggtaaaaaag ctggtgaaga agtagaagtt aatgttactt
    21061 tcccagaaga atatcactca caagatttag ctggaaaacc agttgtattt aatgtaaaaa
    21121 taaatgatgt aaaagtaaaa gaattatctg cacttgatga tgaatttgct aaagatacta
    21181 gtgaatttga ttctttagat gaattaaaag cagatgtaag agctaagtta gaagaagaag
    21241 ctaaaaatag agcagatgca gaaactagaa attcagtagt agaaaaagtt gctgaaaata
    21301 cagaaataga aataccagaa gttatgatac aacatcaaat agataatatg ttaaatgaac
    21361 ttaactacca attacaatat caaggatttg gattacaaca attactagag atgactggta
    21421 gaactatgga agaattaaga gaagagagaa aagaagatgc taaaaaatta gttaagtctt
    21481 ctttagtatt agaagcaata actaaagctg aaggaattga agcaacagaa gaagaattta
    21541 aggctgagtt agaaaaaatg gcttctgctt acaatatgga agtagaaaaa atagaagctt
    21601 ctttaagaga tgccgacaaa gaagatataa aaggtcaaat aaaaataaga aaaacaatag
    21661 atttattagt tgataatgca acaatagctt aataaaataa acgctaacta atatagttga
    21721 cgttatgaaa tgtttagtat ataatgatgt gcaaatataa tttagttaaa tgcgtataat
    21781 aatttacagt agcttaaaaa aagctactgt aaattatata gaataaaggg ggtatgaaac
    21841 catggcatta gtacctgtag ttgttgaaca aacaggaaga ggagaaagat cttatgatat
    21901 tttttctaga ctattaaaag acagaataat cttcttagga gatcaagtta acgatgccac
    21961 agcagggctt atagtagcac agctattatt tttagaagct gaagacccag acaaagatat
    22021 acatttatat ataaattctc caggaggaag tataacttct ggaatggcta tatatgatac
    22081 tatgcaatac atcaaaccag atgtaagtac tatatgtata ggtatggctg cttctatggg
    22141 agcattcttg ttggcagcag gagcaaaagg aaaaagacta gcactaccaa atagtgaaat
    22201 aatgatacat caaccattag gtggagctca aggtcaagca acagatatag aaattcatgc
    22261 aaagagaatt ttaaaaataa aagaaacttt aaatgagata ttatctgaaa gaactggtca
    22321 gccattagaa aaaattaaaa tggatactga acgtgataac ttcatgagtg cactagaagc
    22381 caaagaatat ggtttaatag atgaagtatt tacaaagaga ccgtagatag agagaggtgt
    22441 taatatgtct aaatatgaag aaaaacgaca attaaagtgt tcattctgcg gtaaaaatca
    22501 agatcaagta agaagattaa ttgcaggtcc aaatgtatat atttgtgacg agtgtgttga
    22561 actttgtgac gaaattattc aagaagagat agaagatact atagatgagg atactacatc
    22621 tttaccaaaa ccaaaggaaa tgatggagat tctaaatgat tatgtaatag gtcaagaaaa
    22681 agctaaaaaa gctttatcag ttgcggttta taatcattat aagagaatat acagtaaaaa
    22741 atctagtagt aaggatatag aaattcaaaa gagtaatata cttttattag gacctacagg
    22801 ttctggaaag acattacttg ctcaaactct agcaagaact ctaaatgtac cttttgcaat
    22861 ggcagatgct acatcattga ctgaagctgg atatgttgga gaagacgttg aaaatatact
    22921 tttaaaactt attcaagctg ctgattttga tatagaaaaa gctgaaagag gtataatata
    22981 tatagatgag atagataaga ttgcaagaaa atctgaaaac ccatctataa ctagagatgt
    23041 tagtggtgaa ggtgttcaac aagcacttct aaaaatatta gaaggtactg ttgcaaatgt
    23101 tccaccacaa ggaggaagaa aacatcctca tcaagaattt ttaaagatag atactactaa
    23161 tgtattattt atattaggtg gagcttttga tggattagag aagataattc aaaaacgtgg
    23221 tggagataaa acactaggtt ttggagctaa aatagaaagt aaaaaagaat tagatttagg
    23281 gaagctatat gaaaaagtac ttccagagga tttattaaaa tatggtataa taccagagtt
    23341 tataggaaga ataccagttt tagctacttt agagttgttg gatgaagatg cattaatgca
    23401 gatattacag gaacctaaaa atgctctagt aaaacagtat aaaaagttat tggagttaga
    23461 tgatgttgag ctagaatttg aagaaggtgc tcttcgtgca atcgctaaaa aggccataga
    23521 aagaaataca ggagctagag gacttagaag tatagttgaa agcgtaatga tggaaactat
    23581 gtttgaagta ccatctagag ataatataaa gaaggttata gtaacagaga aatctgtgaa
    23641 cgaagactca gtaaatccta tcatagtact taaggatcaa gaggaaagtg cataagatga
    23701 tgaaaaggag ctttaaaagc tccttttttt atgttaatat gctaaatata aaataggtat
    23761 cattattata aaaatgtgag taatatacct agaataccaa agacgaatac aattgcaatg
    23821 gaaccaattt ttcctttata taaaagataa aatgatgcta taaatgcaat tattccatat
    23881 aaatcccaat taacttcttt ggcagatgaa aaagctgctg ataatatgaa tcctagagta
    23941 attggtctaa gaactgtcaa taagttttct acctttttat tatttttaaa tttagaaaat
    24001 aactttgata taatagttag acctattaat gcaaaaattg taacaccaat agttgcggct
    24061 agagaaccaa agaagccagc agtcttaaat cctacaaatg tagcactatt tattgctaca
    24121 ggacctggtg tagattgtga tatagcaagt aaatccaaaa actcttgatt agttataaag
    24181 tgatatttag atataaattc ttgctggata aatggtagca tggcataacc gccaccaaaa
    24241 ctaaatgccc ctattttaag gaatattaag aagagtagta ttatttctga catagactat
    24301 atacacctcc tccaattatt aaataaatag ggcttatatt gaatacacca acagataaaa
    24361 ctgctataat taatagtagt atgttagttt tagactttgg tagtttcttg aacatgctcg
    24421 taaaagaata caatataaga gctattacaa caggcgcaac tcctttaaaa aatccatcta
    24481 aaattttaga tgatgaattt ttaaagtata gatacgataa gactaagact atacaaaatg
    24541 atggtaaagc agagcctaag gtacatataa gaactcctgg tataccataa agtttatatc
    24601 ctaataatac agatatatta actgccagta ctccaggata actttgagct atggataaat
    24661 aatcaataaa ttcttcctgc tctaaaagtt tttgtttgtt tacaagttca tcttgtataa
    24721 gaggaaccat agcgtatcca ccaccaaatg taaacgcacc aatttttaaa aaggttaaaa
    24781 acaatttcaa cataatagaa acctccaaaa gataaataac atctaagtat actaatatta
    24841 atattatatc ataataaaaa gataatatag tatgatagta ttctaagaat ttatcattaa
    24901 tgttgaaaat taacttgttc aaatatataa tattaaaagc aaagcaatta gactagaaaa
    24961 ggagtaatgt tgatggaaca aaattatact aaaatagatc atgaattacc attaattcct
    25021 ctaagaggat tagctatatt tccatatatg atattaaatt ttgatatagg tagagagata
    25081 tctcttaaag ctttagacca agctatgatg gatgaagaac ttatattttt aacttctcag
    25141 aaagaagcag aggtagatga gccaggagaa gaggattttt atcatgtggg aacaatctgt
    25201 aaagttaagc aaatgataaa attaccagga gatacagttc gtgttttggt tgaaggtgta
    25261 tcaaggggta gagtaaagaa aatagaacaa gaagatgggt atttcagagc agtaatagaa
    25321 gaaatagtat ttgatagtga taatttggat agtgaaacag aagttgaaat tgaagcattt
    25381 gtaagaaatg tatttgatgc ctttgaagag tatataaata ttggaaatag ggtatcacca
    25441 gaaatattaa tatctttagc tgatatagaa gatgtagata gatttataga tacgatagct
    25501 gcaaacatat atctaaaatc aagccaaaaa caagaaatat tagaagaatt tgatattaga
    25561 aaaagacttg aacttattta ttctatatta ttagaggaaa tagatatatt aaaaatagaa
    25621 aagaaaataa ctttaagagt aaaaaaacag atgaataagg ttcaaaaaga atattatctt
    25681 agagaacaat taaaagctat acagaaagaa ttaggtgaag aagaagatat aaactctgaa
    25741 gcagatgagt atagagaaaa gcttaaaaaa ataaaagcac ctaagacaac taaagagaaa
    25801 atagaaaaag agatagataa attttcaaaa atatcttcta tgtctccaga tgtatctgta
    25861 agtagaaact atttagatac tatattctca ttgccatgga ataaagagac aaaagataaa
    25921 ttagatataa ctaaggcaaa agatatatta gatgaagacc attatggatt agaaaaagtt
    25981 aaggagagaa tactagagta tctagctata agaactcttg ctaagtcact taaagggcct
    26041 ataatatgtc tagttggtcc tccaggaaca ggaaagacat ctatagtaaa atcaatcgcc
    26101 agagcattaa atagaaaatt tgtaagaata tctttgggtg gagttagaga tgaagcagaa
    26161 ataagaggtc atagaagaac ttatgtaggt tcaattccag gaagaataat taatggggta
    26221 aaagaagccc aaacaaaaaa tcctgtattc ttatttgatg agatagataa gatggcagca
    26281 gattataaag gtgacccagc ttcagcaatg ctagaagtat tagacccaga gcaaaataag
    26341 gattttgtgg accattactt agaaatacct tttgatttat caaaaatact atttgttaca
    26401 acagcaaata gtctaagtaa tataccaaga ccattattag atagaatgga agtaatagaa
    26461 gtatctggat atatagaaga agaaaaatta aatatagcaa aaaaatacct acttccaaaa
    26521 caaattaaag aacatgcttt aaaagaaaac tttataaaaa tagatgatga aactttaaga
    26581 agtataatca accattatac aagagaagct ggtgtaagaa cactagaaag aactattggt
    26641 aagatttgta gaaaggttgc caaaaaatac gttgaagacc caactcttga agaggttgtt
    26701 ataaataagt ctgacctaga gacatatctt ggaaaagaca tgtttaagta tcaacttgca
    26761 gaagttaacc ctcaaatagg attagtaaat ggtcttgcgt ggacagaagt tggtggagtt
    26821 acacttgaag tagaagtaaa cgtacttaaa ggtaaaggcg aaattgtatt aactggaaaa
    26881 ttaggagatg ttatgaagga atctgcgaag acaggtatct cttatataag gtcaatagtg
    26941 gacaagtttg atatagaccc tgaattttat aagacgaatg atattcatat acacattcca
    27001 gaaggtgctg ttccaaaaga tggaccatca gctggtataa ctatggctct tgcagtaatc
    27061 tcagcactta ctaaaagacc tgtgcctgga aatatagcaa tgacaggaga gataacttta
    27121 agaggtagag tcttagcagt aggaggagtt aaagaaaagt tattagcagc tcatagagct
    27181 ggtataacaa aagtattaat tcctaaagaa tgtgaagctg atttagatga aataccagaa
    27241 aatgtaaaag aaaaaatgga gtttgtgctt gtagaacata tggatgaagt attagaacaa
    27301 gctttattaa agagtggtga aaataatgaa aattagaagt tcagagataa ctatgagtgc
    27361 tgtgaataaa tcacagtatc cagcagaagg aatcccagag atagcattgg ctggtaggtc
    27421 aaatgttgga aaatcatcaa taataaatac attgcttaac agaagaaact ttgctagaac
    27481 cagtcaaaca ccaggaaaaa ctagaactat aaatttttat ctaataaata atgaatttta
    27541 ttttgtagac cttccaggct atggatatgc aaagatagct aagtctgaaa aagaaaagtg
    27601 gggaggtata atggaacgat atctagaaag tagacaagag ttatgttcta tattcctact
    27661 tgtagatatt agacatgagc ctacagcaga tgataagctt atgtatgaat ggataaagca
    27721 ctttggatat aactgtgtag ttattgcaac taaggcagat aaaatatcta gaggacaata
    27781 tcaaaaacac ataagtataa taagaaaaaa attgcaaatg gaaagtagtg aaaaagtaat
    27841 tcctgtttct tcactaaaaa agactggtgt tgaagaatta tgggaagaga ttgtaaatca
    27901 atacaatcaa catggatatg aaataacagt agattaaatt taaaatgtta aatattgaca
    27961 taagatttat ttgaataata aatgtaataa tagttagttt taattatatt aatattaaag
    28021 taaaatatag gatgccttaa aatagtttta atgaactttt ttttggcatc cttattgttt
    28081 ataaacaata aatatcagta attttgctaa atactaataa attttagtaa ggtatgggaa
    28141 aattagtata aaatagttaa actaaaaaat tattgattta tgtagtcagt aataaatagc
    28201 atttaagaaa tagatttatc tgttttcctc ataaagaaaa cagttagtat aagccctaca
    28261 aaacatactg atgctgcaat ccaataagac tgattgctag ctataacata ggctgatgtg
    28321 tgacttttaa acttttgatt gtatgtaaga ctttgtgcaa aaaaactact aaaaaatgct
    28381 gttccaagag caaatgataa attacgaata gttgcaagaa aactgcctcc gtacccctgt
    28441 ttttgaggag gaacatctgc taaaatacta ctattgtttg gtgaactaaa tgctcctagc
    28501 ccaagtccaa aaataactaa acatacaatt aaaaggtaca atggagaatc tgcttttaaa
    28561 agtgccattc caactagtga gatggtcata aatgaaaaag atgctgttag aatgtttttt
    28621 gcaccgtgtt tatcagaaag tgaacctgca ataggtgcta taagtaccat aataagtgga
    28681 tgtacagtca ttacataacc agccatcata ggagataaat tttttaattg ttctaaataa
    28741 aatggaagta gaaaagatac tgccatttga ggaaaataac aagctactcc aatgatattg
    28801 cctacagtaa agtttctatt tttaaataga gggaggtcaa taaagctttg ttcaaatttt
    28861 acttctctta atgccaacaa taagaagatt ataagtgctg ttatacctaa atacaatctt
    28921 gtattaccct tctcattcat tgcaagtaat ataagcgtag tgcaagatgc gaaaagtaga
    28981 agacctggaa tatcaaagct cttgttttgt tcatccaaaa caggtttagg cagaaattta
    29041 atgccaagaa agactgctat aataccaata gggatattga taataaaaat agaaggccat
    29101 ccaaaatgtt ctaaaattat acctccaatt acaggaccac tcatatttcc tataccaact
    29161 acagctccag tgattcctat agcttttcct ttttcatttg ctggaaatgc attggaaact
    29221 ataccaagcc cagtagccat taaaatactt gctccaactg cctgaaagat tcttgaagaa
    29281 attaatgttg ataaattgtt tgacatacta cacagaaaag aacctattgt aaatataaaa
    29341 aatcctaatg tgtatagacg atttgaacct actttatcgc caagttttcc gaaaaataac
    29401 atagtagctg ttacaacaag catataagct gttacaaccc actgaatttg tgacatgtta
    29461 attttaaagt cagcagcaat tgtaggattt gcgatattta gtatacttcc atcaagagta
    29521 gacataaata caccaataca gatgataatc aatactatcc atttttgttt catgataaca
    29581 ctccaatctt aatagatttt ataagtacga tataattgta aaataaacaa caaaaaaagc
    29641 acctgtatat taggtacctt gaatgtgtct aatttcatga ataaatacgg tagttgaagg
    29701 atttgtatag attactcatg taaaattaca taaaggtact catatactat tttcttctac
    29761 catccagatt ttactgtcgg ctttggaata tgaccaaatt atgccataag gctcgcgggc
    29821 ttttaccgcc gataggtaat ttcacccgtt tatgaagaaa aacagatgta ttttgtaata
    29881 ttattttaac ataaaattat aatggaaaca attggattta agtaatatcc agctgtatta
    29941 caatacaaat atttcaatat ggacacttaa attgtattta tagatagaat aaggcacagt
    30001 atgagaatct ataataatta gataaaatta acctgttatt agtattagat ggcaagtttt
    30061 aaatttgtca aaatcagaaa gctgtaataa aattcttata atatgaatat cttaattaag
    30121 agatattgta aattatgagg aggcgctaat atggaaggaa aggtaaagaa ggcattcccg
    30181 ggtggaaata catcacaagg ctcatattct ttttttgact atataattcc tgaaaatgta
    30241 aaaagagttt tttgtttaaa gggtggacct ggagtaggaa aatcctcact tatgaaaaaa
    30301 atttataaag agtttttgca tagaggatat gatattgatt tatatcattg tccttctgac
    30361 ccaagttcgt tggatggttt agttataaag aaattaggcg tggtacttat ggatgcaact
    30421 gccccacata ctatggaccc aaagctacct ggagctttgg atgagataat taatttaggt
    30481 gattactgga atacagaaga attagaaaag aataaacaag aaatatcagt ttatgataaa
    30541 gatattagta attcatttaa aagagcattt aagtttttaa aatcagcaga accaatcttt
    30601 agagacatag aagaaaaata ttctgattgt atggattatg gcaaagtaaa tttggtcaca
    30661 gaagaattta taaaaaggtt atttgatgga gttaaaagca caggaaatct aaaaagagaa
    30721 aagcatttat ttggttcagc tataactcct gtagggtgtt tagattatac agaaaacatt
    30781 ttaaaagatg taaagaaagt ctattattta gatggagaaa taggaactgg gaaaactaca
    30841 ttattaaaca aagtatataa gaaagctatt gaaaaaggtt taaatgtaga agtttatcat
    30901 tatccactta ttccagagaa aattgaaact gtactattaa ctgatttaga tataggcata
    30961 actataagta cgacttttaa agaagaagat acaattgatt taaatcagtt tttaaataga
    31021 gaaaaactac ttaaatatga agaagatatt aaatttgatg aaaaagtttt agatgattta
    31081 atttgttggg cagtactaaa tcttaagaga gccaagtcta aacatgatat tatagaaagt
    31141 tactatagtc ctaatatgag atttgatgaa gtagggaaat taagagataa attaattaaa
    31201 agaattttaa aatatgagga aaacttataa acgtatatgt ttaaaattaa tgttaataat
    31261 gatataattt ttagtaaatt ggtgtagctt tgaggctatg ccattttact tttttttgct
    31321 aaaaaatgat attaataatc tccaaagcaa ttatttgttt ttcataatta ttatttcctt
    31381 tcctaattta tgttttttta taatatcaaa acaatgttta ttgaaagttt atataatttt
    31441 aagaacatct aaaaatgcat acttgatatt ggtaaattag tgataggagt tcaatgtatg
    31501 atattatata ctaaagatga attttaatat ataactttga tataataagc atatgtaaat
    31561 gtttaatatt taattaaaga aaattatcat ataaaaataa atttgtaagg agcaatacag
    31621 tatgaaaaaa caatatgtgt ttataatact agcaagtact attttaggta tacttgttgg
    31681 aaccatattt agagattata gcaatgaaga aacagtttat acaagcaaag acaagtcaat
    31741 aagaaaagaa ataaaaatga caagaaaatc tataaaagaa ttaaccaaag agaaagacaa
    31801 gttagataaa gaaattaatt caatgaaaca aaatcaaaaa aattctgaag aaatatcaga
    31861 aatagaaaca cttagagata gtctatcata ttcagatgta aagggtagtg ggataatatt
    31921 aagtatagat gctatagatg aaaaaacagg gaatatagct aatagtatag actataataa
    31981 gattcttgta aaagttataa atgaattaaa agtaaacgga ggaaaataca tagaaataaa
    32041 tggtcaaaga attaatcaat attcagaagt tgtacttgca ggaagccata taaatataaa
    32101 tggagttcct gtagcacaac catatgaaat aaagtgcatt ggagataagg agaaactatc
    32161 taattatgta gataaaggta gtaaatattt agatagcata caaaccaatt atccaatgaa
    32221 aataagcata aaaactgaag aaaatatctc tatgaaaaaa atgaatatac ctaataaatt
    32281 aaagtatata aagggtgatt aagattatat tagaggaaag cagtttgcca atgttaatac
    32341 cagaaaaact tgcaaaaaaa tataatgtat ttccagttga gtttcaagat gataatttag
    32401 ttgtagaaat agaagatgag gatatttatg ctctacagga cttgagatta gctacaggta
    32461 aagaaattat attgaagaag gagaaaaaag aacttataag tgaaaagatt gaaaaatatt
    32521 ataatagctt tgaacttgat gaggattatg caaaaaaatt atttgaaaat cttttagaaa
    32581 aagctataaa agaaaacgca agtgatatac atatagaacc atttaaagaa catttaatag
    32641 tgagaatgag ggtagatgga gaactaaagg aagtatcaaa gtttttagtt gatgtctatc
    32701 catcattgtc tacggttata aaattaaagg catcaatgga tataacagaa aaaaggcttc
    32761 ctcaggatgg tagggtggat ataaagttag gtggaaattt aattgacatt agagtttcat
    32821 caataccaac tgtctatggt gaaaaaatag ttttgaggat acttaataga gatacttttt
    32881 taaaagacaa attagaactt ggtttttcag aggaagctat aaaatctata aatcgtataa
    32941 taaataaaag agcaggaata ttattagtga caggtcctac aggtagtgga aagactacaa
    33001 cagtatattc cttattaaat gatttaaaag gaataaataa aaatattatg actatagaaa
    33061 atcctgtaga gtataagatg gatggcataa gtcagattca agtaaattca aaagtagggt
    33121 tgagctttga tgtaggtctt agagcgatat taagacaaga cccagatata ataatggtcg
    33181 gagaaataag agatgcagaa acagctaaga tagcagtaag agcagctata acaggtcatt
    33241 tagttataag tactttacat actaatgatg cagtatcttc catagctaga ttactagaaa
    33301 tgcaaatacc accatatctt ttaaatgctt ctcttatagg tgttatatct caaaagttgg
    33361 ttagaaaagt ctgcaatcat tgtagccatg agattatgat aaaagataat tttagtggag
    33421 atgtaaatac taaggtagct gtagggtgtg aaaaatgtaa tgataaagga tactttggaa
    33481 gaacagcaat ttatgaaatc ttagaaatta atgatgatat aaagacatgt ataagaaata
    33541 tggaggattc tagtactatt aaagatgtag cacaaaataa tggaatgata acatttgaag
    33601 atagttgtaa aagactaata aatgaaaaaa taacgacatt agaagagtgt ttagtagtaa
    33661 atgaaatgat ttaactgaat tgtatagtta aacttcgttt ggtcagttgt ctttatttaa
    33721 tctattttaa ttaagatgtt tgagtataaa ttatatttaa gtgaaataaa attaaatgca
    33781 ttaaattaga aaatattaag tttatttaat tgtaattaat ataatttgga aggtattata
    33841 gtacatgaga ttatctaaaa atatatttta taatttagaa aagttttatt tagtattaaa
    33901 tagaatcagt gataaagaaa ttagagtaat ttgcaaagag ataggcatat tgctggaatc
    33961 tggatgtgaa attacaaaaa tatttgaaat cattgagagt cagtcaagta aaaaagcaaa
    34021 gaatttgctt agtatagtat caaatcatat tcaaaaaggt aactcaatag cagaatcatt
    34081 tcaaataaca ggtatatttt ctaaattctt tataagtatg ataaaagcag gagaaactag
    34141 tggaaactta gatataataa tgagtgattt atctaattat tatgataaag aatacaaatt
    34201 aaaaatgaaa ataataacta tttcaatata tccaataata cttataatat tatctatctt
    34261 atcaatgttg tttatattcg tatttgtaat acctaatttt caggtggttt ttaccaacaa
    34321 tggaattgaa ccacctttaa taactagagt tttaatggga atatctacag tggttacaaa
    34381 taacttagct tatataatat ttagttttat attgttttca ataggaagca tttatttctt
    34441 tataacaaat gataatataa aaaaattgat taattcgtta aaattcaaaa taccttttat
    34501 aaaaaaaatt aatcagttag tagctacaac aagattttca agggcattgt ccgttttaat
    34561 tagcagtgga atacaaattg tggaagctat agacatgtca gctagtgtta tagacaacga
    34621 atttatttat gaaaggttaa agatttccaa taattatata aaaaaaggaa atagcatagg
    34681 taaatctttg aatttagcaa atgtttttcc aaaattattt atttcaatgg caaatacagg
    34741 agaagaaagt gggaaactag ataaaagtct aaatgtaata aataaatttt atgaaaatga
    34801 attaaataac aaaatagagc aaataatgaa atttatagaa cctatgctaa ttgtatttat
    34861 gggattaatt attggtactt ttattttagc aatggttgtt cctatgtttg atgcaattac
    34921 taatttttag agagaaaaat aaattttatt agatgaaact tttgaaaagg agagaatatt
    34981 taattgataa atttgataaa taaaaaacga aaaggattta cacttgttga aatgattgta
    35041 gtagtaacta ttttaggcgt tatatctagt atagcattag ttaagtatag taaggttcaa
    35101 gaaagtgcca aattaaatgc agactatacg aatgctgcta atatagtaac cgcagctagc
    35161 atggcaatta atgatgatga aaagacaata gactctctaa gtgtagagac attgaaggaa
    35221 aagggatacc taaatactgt tccagttcct cagagtacat caggtaaatt cgaacttgtc
    35281 ataaatgata gcggaacaga tataagcgta aatataaatt ctaagcaatt ttatccaaaa
    35341 taatatttta tattgattgc tgtaagtttt aaaattattt ttatttaaga aggagatggc
    35401 tataattaaa aaaattctaa acttagaaat aaatgatgat tatataaggc ttgtattttt
    35461 aagaaaaagt cataaaaaag tttttataga taaatcaatt ataaaagaga ttaactttga
    35521 tataaaaaat gatagtaatt cgattgagaa gattaaatat atagaagatg tagttagatt
    35581 tgtaaaagag gagattggta aatcaaaaat attatataaa aatttatact ttaacattca
    35641 aattcaggat atagtcatta gaaatgttga agttctaaat actaagaaaa aaagagacat
    35701 attaagcatg attgaatttg aaataacaca atacattcca ataaacataa ataactattc
    35761 aataaaatat aaagttataa attctaaaaa tgataaattg aatatacaag taattctttt
    35821 cccaaagagt attattcaat taattaagaa catttcagaa aatctaaata tgaatccaaa
    35881 gactataaat ataaattttg atatattaca aaagcttata aacttaaatt taatagagaa
    35941 tttttcagaa gaaggggtat ttatagaatg taaaaaaagt cagttaatta taaatataac
    36001 aaaagataaa aaaataagag aaacatactt gctatcaaaa gagggaaaat catatgagtt
    36061 cataaaaaga ttattaaggg attttaagta tgtttattac tatggtatag aaaattgttt
    36121 tattgaagaa tactttaaat atacagataa atctattgaa gtaaatccat taagattaaa
    36181 agataaagta aaagtagaaa ataattttga tgcagattta gaagacaata ggataaatta
    36241 tataagtaat ataggaatga ttatttaagt gaaagtggat aaaacgataa attttcttaa
    36301 tggatttaaa aaaactaaac catgtaataa aatctataaa ataataatag tcttaatttt
    36361 aacgtgtatt ttatttaaat catttatgta tgtgaaatct ataaatgaac ttgaagatta
    36421 tataagtcaa aataagctag tggataaatc aagacacact ttaccaacaa cagataaaac
    36481 tagagagaaa ttttctaaaa taaaacttaa tgaaataaaa aaaatatatg aaacaattgg
    36541 aataaatatt attactaaaa tatcgataga taaaaataag ctagagattg aaggtgtgtg
    36601 tagtgattta gatgttttaa acaatctaag gaaaataaag tacataaaat attattacat
    36661 agacagtatt gtaagagatg gagaatatta tagatttaga ataaaaagtt agatgggtga
    36721 ttatttttga gattaaataa tagagaaaaa aatctactta aaatattgtt aatattagtt
    36781 attatattgg caagtgatat agcagtaagt tatttggaag aaaacttaac tagtttgaag
    36841 aatgaaaagc aaaatataat aaataaaata aataatcaag ataattatca aataaaggat
    36901 aataagcata tagatgataa atatatagaa agtgttgaat caaataaaaa tgaagaatta
    36961 aaaaataatt ttaataactc atttttagat aaaaaaacaa ataaagatat agtgttatta
    37021 gtagaaaatg aactgagaga tattgtgaat gtagaatata ttaatcaaga aagtagttta
    37081 gataatcaca ataaaaaaca agttaattta gaaataaaag ttaatggaga acttgcaaat
    37141 ttgttgaaac ttgaaggtgt aatgaagaag ttaagactaa ataataaact tgaaaagata
    37201 gaaattaata aattaaaagt caataatttt gatgttcaaa atattccaaa tgaatataaa
    37261 caagaaaaag acaatattgt tgaatgtaaa atgacagtta gagtcatata acaaaaaaga
    37321 atagataaag taaaaaacta ttatcaatta ataaaatttt atagaggaat tagttttacg
    37381 ataattcatt tctacaagag ggattgttga tgattttatc gaaatcctaa ttaaagttaa
    37441 tatattgtac caaaatataa gtgaatttaa tagaatattt acttatacta tagattgatt
    37501 aataaaaaaa tggtataata acaaattgta ctttaattta ataataaggg agtggaagtc
    37561 atattgttag ggagaaatga gctatgccct tgtggaagtg gcaaaaaata caagaaatgt
    37621 tgtttaaata aagatattgt ttcagaaaga gcatgcagaa aaactgaact ttcacaaaaa
    37681 caatatacag atttatattc aaagttatat gattattcaa gacaggataa gtttaaagaa
    37741 gaatgtgaaa aagctaaaga aatgttttat ataatgcaaa atgatagtgt aaatgaaaaa
    37801 tttgaaagat tttttaatac ttatttaata caagaccaca taatggaaaa taaaaaggtt
    37861 atgacagttg gttttcttga agaaaatggt gcaaacctaa gtcaatcaga agtatcaata
    37921 ttaaaaagta tgtttgaatc atacgtaagt atttatgagg taaaagaagt ttctgctgga
    37981 aaaatagtat taaaggactg tttaagtgga aatgaacttt gtacagaaga tgtaaaactt
    38041 ctgagaagtt ttaaaatcgg aagttgtatg atagctagaa tagttgatat tgaaggaact
    38101 aacatattga tagatataac tataagtata tcaaatgagg ttaaagatat aattttaaag
    38161 gatattatga atctattcaa tcaatatcaa gatgtataca aagatatgaa gtcgttctta
    38221 atttatcata cacatatact atacaagtat atacaacagc ttttagaccc aagtatagct
    38281 gaatatttaa agagagaaag agataaaaac gatacaaaag ttaattcaga aaatgaatta
    38341 gctgaagaag aatgtaaagt tttagatact cttaaagaaa atgtagaaaa agaaaatata
    38401 gatgcatgta tagagttttg gaatgaatat aagaaaaatc atgaaaatat aaaaggagct
    38461 gaaaatggtt gggcagctgc tgttgaatac tatgttaaaa aagaagcagg acaacctata
    38521 actcaagttc aaatatcaaa gaaatacgat ataagctcta gtacactagg aaagagatac
    38581 aaggatttaa aaatatctta attaattata aaaagcttta agtcatagat aaagaatcta
    38641 tagtataata tatgtataat gtttagaaag aggtattaat aatgagtctt agtttaggaa
    38701 atgcaattgc tgtatcaacg aactttataa aatctaaccc agctgtacct gtgtacaatg
    38761 gagaagaaat atatgcagtt atttatcata tagaaatagg atataataat ggtgtatcac
    38821 ctgataccaa acaatatata ataatagact ataaagagtt tgatttatct atggataaaa
    38881 aaaatgaact aataaatatt gctaaagagt actgtaaatc taaaggtatt gtagaaaacg
    38941 aaaaccttga aataaacctt ttagacaatg aagaagcaga gaacttctta gaaaaggtgt
    39001 ttaataatat gaaggttata agaggtctta taactaaaaa aggataaata aatggactat
    39061 ataggaatag aaaatataac accttatgaa aatacatatg aatttagtgt atatgaatat
    39121 gatgatgaaa tcaccttagg tagtgaaaag ttatatgtat gtgaattaag ggttgtattg
    39181 attaaagtta attctctgta tgttgaaaga ttgcataaat cagttgaagc aatggtctta
    39241 gtaaaaaact tgaaaaaaga tttagataaa acacttgttg taaacaaaat aaagaatttt
    39301 gtgctagatg agatttgggt agaaaatcta gtaaaagaga atatagaagt tatatttgta
    39361 gaaagctagg aataacccta gcttttttat attacaatct aagagaggaa aacaatatgt
    39421 taagagtatc taatgtaaaa cttggaattg ataaagatat atctttatta aaagatgtta
    39481 tacttaagaa gctaaaaata aaagaaaaaa acttagtcaa atatagtata tataaagaat
    39541 ctatagatgc tagaaaaaaa ggaaaaatgg aatttgttta ttctgtagat gtagaagtta
    39601 aagatgaaaa taaaatactt aactcaaaaa taaaagatgt aacaaaaata aaggaaatca
    39661 gatacgtaaa tgtacctgtg ggtgataaaa aattaaagaa taatcctttg gtaattggta
    39721 gtggaccagc tggtttgttt gcaggtctgc ttttagctca aatgggttat gaaccaatca
    39781 tacttgaaag aggtcttgat gtagacagta gaaccaaaga tataagtgat ttttggacaa
    39841 ctagaaaatt aaaaaataat tcaaacgttc aatttggaga aggtggagca ggaacttttt
    39901 cggatggtaa acttacaact agaataaaag atatacgatg tagaaaagta ttagaagagt
    39961 tagttcagtt tggggcacca gatgaaatat tatactcaca taagccacat gttggaacag
    40021 atatattaaa aaatgtagtt aaaaatataa gaaatgaaat aataagttta ggtggtcaag
    40081 ttagatttaa ttcaaaagta acagatatag ttgtatcaaa tgattctata caatctgtaa
    40141 taataaatga tactgaaaaa atagatacag atacaattat attagctgtt ggacatagtg
    40201 caagagatac ttatgaaatg ttgtattcaa gaggtataaa aatagttcaa aaaccttttg
    40261 caataggagc tagagttgaa catccacaag atttaataaa taaagcacag tacaaggatt
    40321 tttataatca ccctaggtta ggagctgcag attatagact tatagagcat gtttcaaatg
    40381 gaagaacagc atatactttt tgtatgtgtc caggaggtag tgtcatagca tctgcatcaa
    40441 atgattttga aatagttaca aatggtatga gtgaacatgc aagagataaa ataaatgcaa
    40501 atagtgcatt tttagtaaat gtaacgccag aagattttaa gagtgataat ccactagcag
    40561 gtgttcattt ccagcagaag tatgaaaaat tagcttttga attaggtgga aaaaattata
    40621 atgcaccagt tcagcttgtt ggagatttta taaacaataa gacttctttg aatttaggaa
    40681 gtgttgagcc atcatataga ccaggatata cacttacaaa tttaagtgaa tgtttgccta
    40741 gcttcgtaac agagactatg agagaagcgt ttatatctct tgataaaaaa ttgaatgggt
    40801 ttgcaatgta tgatgctgtt ttgacgggag tagaaactag gtcatcatca ccaataagaa
    40861 tagtgagaga tgaaaatact ttagaatcag tgagtattaa gaatctatat ccatgtggtg
    40921 aaggtgctgg atatgcaggt ggtatagtta cagcagcagt tgatggtata aaatgtgcag
    40981 aaaaaataat acaaaaatac accaataata caaaaattta acataaactt aatgattttt
    41041 taatatttaa catgaattta acattatcac tcctataatt tgataaaata caataggtta
    41101 taaaattttt agatacagta atctctttac aaggaggaaa taatttgaac attataataa
    41161 gtctaatggg tggattaggt ctgttcttat atggtatgaa ccttatggga gaaggtcttc
    41221 aaaaatctgc tgggacaaag ctaaaaaaga taataaaact acttactagt aacctattta
    41281 tgggagtttt ggtaggtaca ggagttacag cagtaataca aagttcaagt gctactactg
    41341 taatggttgt tggtttcgta aatgcaggaa taatgacttt aaaacaggca ataggagtta
    41401 taatgggtgc taatataggg actactgtta cagcccaatt ggtatctttc gacttaactg
    41461 gtatggcccc agtagcatta ggtgtaggta ttatacttta tttatttgga aataagccta
    41521 gaataaaaaa tatagccgaa atacttatag gttttggtat attatttaca ggtatggatt
    41581 ttatgaagat ggcagtggag ccactaagag actatcaagg atttactgac ttacttgtta
    41641 catttggtag atatccacta cttggattat tattgggatt tgggattaca gcaataatac
    41701 aaagttcaag tgcatctatg ggtatgttgg ttgcactggc agcagaaggt ctagtgccac
    41761 tatcagcagc actgccaatt ctttatggcc aaaatattgg tacatgtgta acttcactgt
    41821 tatcaagtat tggtgctaac aaaaatgcac gaagagcagc tatgatgcat ctaatcttca
    41881 atgttttagg aacggtgata ttcttaatat tcttgaataa accagtagta agcatggtta
    41941 caagttggga tccaagcaat gttgcaagac aaatagccaa tacacataca ttgtttaata
    42001 taatatctgt attgatactt ttaccattta caagtcttat tataaaacta gctataaagc
    42061 ttgttcctga tagagcaggt gatatagatg aagatgaaac taaaactatt aaatatatag
    42121 atgatagaat gatagaaact ccttctatag ctcttgcaaa tacgataaaa gaagcacttc
    42181 gtatgggtga gaaggcgaag gaaagcctaa atgcatctat ggaagcttta gtagaacatt
    42241 caactgaaaa aatagataag acatatagac gagagagatt aatcaatgat ttacagaaag
    42301 ctattttaaa ttatttactt aaactttcaa aagcagcttt agatgatgat tcaagagaag
    42361 ttgtggatac tttgtttaat acagtcaatg atatagaaag aattggtgac cacgctaaaa
    42421 atatagctga attatcacaa gttgcaatag attcaaatat ttatttctca gaagaaggac
    42481 aatctgaact tgatgttatg tataatagag ttgtttcagc atatacttat gcattagaat
    42541 caatgaggag cgataatgtt gatttagctt gcaaggttat aaaaattgaa gaacaagttg
    42601 atataatgga gaaatcttgt agagctaatc acatgtatag attgaataat aatctatgta
    42661 gtatagaaaa tggagttatt tatttagatg taataagtaa tttagagaga atatctgacc
    42721 atgctgtcaa tatagcacaa caagttatag cgaagagatt aggaaatgat taaaaataat
    42781 taatttaaaa taatataaaa tttaaaatag aggataaata aaagagaaac tttaaatgat
    42841 acgtttagag tttctttttt tgtaaattta tttgactaaa atttttaaat ttatacatag
    42901 ttatagtatt tagaagaatc gatttcctga taataaatga tgagatatgt atgattttgt
    42961 ggcaaacttt taaaaaaaac acctatattt tgtgttataa tctctttaaa acgaatatgc
    43021 tgaaaagagg gatttaaatg ggaaaaataa attttgatta tagtaaagct acagagtttt
    43081 tttgtcaaaa cgaaatagat gtcatgcaac catatgtaga tgttgcgcac gacatgttac
    43141 ataataaaac tggtttagga aatacttttt taggatggat agaccttcct aaaaattatg
    43201 ataaagaaga gtttgacaga ataaaaaaat ctgctgataa gataaaatca gactcagatg
    43261 ttcttttggt aataggtata ggaggctctt atttaggttc gagagctgct atagatatgg
    43321 taagtcattc ttttaggaat ggacttaaaa aagagcaaag aaaggctcca gaagtatatt
    43381 ttgtagggca taatataagc tcaacatata ttatggattt attagatata attgaaggaa
    43441 aggatatttc tgtaaatgta atatctaaat caggaactac tacagaacca gctctggctt
    43501 ttagaatatt taaagattac ttagagaaaa agtatggtaa ggaagaagca agaaagagaa
    43561 tttatgcaac aacagatgca agtaaaggtg cacttagaca gttagctaca gaagaaggat
    43621 atgagacttt tgtaatacca gatgatgtag gtggtcgttt ttctgtattg acagcagttg
    43681 gattacttcc tattgctgct gctggacttg atattgatgc tatgatgaaa ggcgcaaatg
    43741 atgctagaga agcatttcaa aatcctgact taaaaagtaa tgatagttat agatatgctg
    43801 ttgctagaac aattttacat agaaaaggaa aagatgtaga gttattagtg aactatgaac
    43861 ctcaactaca ttatgtaagt gagtggtgga aacagcttta tggagaaagt gaaggaaaag
    43921 aaaataaagg tttattccct gcttctgtag atttctcaac agatttacat tctatgggtc
    43981 aatacataca agatggaaaa aggcttttat ttgagacagt acttaatgtt gaaaactgta
    44041 agagaaatat aactataagt tcagaggaag tagacttaga tggtttaaat tatttagcag
    44101 gtaagactgt agattttgta aatcataaag cttttgaagg aactctattg gctcatacag
    44161 atggaaaagt acctaattta gtaataaata tacctcaact agatgagtat aattttggat
    44221 atttagttta tttctttgag aaggcttgtg gaataagtgg atatttattg ggagttaatc
    44281 catttgacca accaggagta gaagcttaca agaaaaatat gtttgcttta ctaggcaaac
    44341 caggttatga aaaagaaaag gaagagctag aaaaaagact taaataattt taaatagtta
    44401 aggtttaatt aagattaaaa taatataatg aaatcatcaa aaaggagttt actcaaaata
    44461 gatgatttca ttttttttat gaaaaattgg gaaaaatata ttttgataat ttatattata
    44521 ttaagatagg gagtggtatg agatgtcaag aagaaagaaa gggataagtt tagtaatatt
    44581 agttgctata ataagttcaa tacttagtag ttttctaaca ataattttag ttaaggacaa
    44641 tttagtaagc aaatctacag gaagttctac gccgatagtt gtaaatgatg atggtaagag
    44701 tcaaaatatt tatcaagcag ttgcagaaaa agctacgcca tctgttgtag gtattacaac
    44761 aactagtgtt gatactagta atatgtttgc aataccaact gaaacacaag gtgtaggaac
    44821 tggaatcata gttgattcaa atggatatat acttactaat tctcatgtta tatcagatgg
    44881 tcaagctaca agtgtaaatg tattattcaa tgatggttca acaacttcag gtaaagtagt
    44941 atggtttgac caacaacttg atttagctat agttaaggtt gataaaactg gactaacacc
    45001 agcagaattt gctgatagtg acaaagtaaa agttggagat atatcaatag caataggtaa
    45061 tcctcttgga ttagattttc aaaaaacagt tactcaaggg ataataagtg gattagatag
    45121 aactatacaa acagaaaaaa ctaatatgac tggtttatta caaactgatg caagtataaa
    45181 tgcaggaaat agtggaggac cattgttaaa tcaaaaaggt caagtaattg gtataaacac
    45241 agcaaaagct tctcaagcag aaggattagg atttgcaata ccaatcaata cagctaagag
    45301 tatagttgaa gaagtaatca aaaatggaaa atatgaaaaa gtaactttag gcataaaagg
    45361 tacagatgta tcaaattatg aagcagcaac aggtacaaaa ttaagtactg ataaaggtgt
    45421 ttatgttgca gaagtaatat ctggttcatc agcagaaaaa gctggagtaa aggtagggga
    45481 tattataact aaagtaggag atacagatat aacaggtatg aatgatttaa ataaaaagtt
    45541 gtatactttc tcaaaaggtg ctagtacaaa aataacagta aatagaggcg gaaaagcagt
    45601 aacaataaat gtgaatttct aaatatgacc aaaaagatag agactacatg gtaaagtgta
    45661 gtctctattt ttatttaatt tttatagtat atacatctaa attaattaaa atgatgtatt
    45721 gtttatagtt tattgctata ttttcttata aaaataaatt taataaatat ttaaatttaa
    45781 tttacaaaaa caatataaat atcataataa aataaaattt tttaatatta ctaaaaatat
    45841 atagacaaaa taataacaaa tatagtatta tgtaattgta gaaatgcttt tcataggtat
    45901 attctatgaa gatgaattgc ataaaaatga aaaaatggaa tggatattat ttaggggtga
    45961 aaaatcatga atccattagt tataaactta caaaaatgta gcatacatga tggaccaggg
    46021 ataagaagta cagtattttt taaagggtgt ccacttgaat gtgtttggtg tcataatcca
    46081 gagagtcaaa catatacaaa acaagttttg tataatgaag aaagatgttc aaaatgtgaa
    46141 gcatgtataa atatatgccc tcataaggca atttacaaag gtgaaacaaa aatatgctta
    46201 gaccaagata agtgtgagtt ttgtgaaact tgcttagact attgtgtaaa caatgcaaga
    46261 gagattgttg gtcaagagta ttctgtaaga gatttggtta aagagataga gaaggataga
    46321 attttctatg aagaatcagg tggtggagta actctatcag gtggagaagt aatggctcaa
    46381 gatatggact tcatttgtgg agtaataaac atgtgcaaat caaagggaat ccatgtagca
    46441 attgatacat gtggctatgc aaagtcagaa aattatgaaa gagttgctaa atgtgcagat
    46501 ttgtttttat atgatattaa gcttattgat gaagataagc acataaaatt tacaggaaaa
    46561 tcaaatgact taatactgaa aaatgttaag attttaagtg aattaggggc taacataaat
    46621 ataagaatac cattaattgt aggagtaaat gtagatgatg aaaatttaga ggttaaaaaa
    46681 atgatagagt ttttaaagcc tttgaatata caagcagtaa gtcttcttcc atatcataat
    46741 attggtaaac acaagtatga taaaatttat aaaaagtatg aaggagaaga actacaaaga
    46801 ccatcagaag aaaaattaga ggaaataaaa agactgtttg aagcaagtaa tttcaatact
    46861 aagattggag ggtaataaaa tggcaagagg aacttttgag agaactaaaa aattaagaga
    46921 agaaagtatt aatgcagaac cacacatatc tattgaaaga gcagtactta tgacagaagc
    46981 ttataaaaaa tatgagggaa gtgtagagat tcctgtactt cgtgctttat catttaagca
    47041 ttatattgag aatagaactc ttagcataaa tgatggagaa ttaatagtag gtgaaaaagg
    47101 tgattctcct aatggagcac caacatatcc agaaatttgt tgtcatacaa tggaagattt
    47161 agaagtaatg cacaatagag atataataaa ttttagcgta tcagaagaag ctagaaaaat
    47221 acataaagaa gaaataattc ctttttggaa aaagagacaa acaagagata agataataaa
    47281 tgcaatgaca cctgagtggt tagcagcata tgaagcaggt atgtttacag agtttatgga
    47341 acaaagagcc ccaggacata cagtttgtgg agatacaata tataaaaaag gatttttaga
    47401 tttaaagaaa gacatagaag caagattaaa agagctagat tttcttaatg atttagatgc
    47461 atataataaa aaagcagatt tagaagctat ggcaatagct tgtgatgcaa tggttatatt
    47521 aggtaaaaga tatgctgaga aagcaagaca aatggcagaa gaagaaacag atgaagctaa
    47581 gaaacaagat ttattactaa ttgctgaaac ttgtgatgtt gtaccagctc acaaaccaga
    47641 aacttatcat caagctatac aaatgtattg gtttgttcat ataggggtta ctactgaact
    47701 taatatatgg gatgctttta ctccaggaag acttgaccaa catctaaatc ctttctatga
    47761 aagagatgta gaaaatggaa tactagatag agatagagca caagaattac ttgaatgttt
    47821 atgggttaaa tttaacaatc agccagcacc accaaaagtt ggtataacat taaaagaaag
    47881 tagcacatat acagattttg caaatataaa cactggtgga ataaatccag atggtcaaga
    47941 tggtgttaat gaagttagtt atataatact tgatgttatg gatgaaatga aattgataca
    48001 acctagttca aatgttcaaa taagtaaaaa gactcctcaa aaattcttaa agagagcttg
    48061 tgaaatatca agaaaaggat ggggtcaacc agcattttat aatactgaag caatagttca
    48121 agagcttatg gaagctggaa aaactataga agatgcaaga cttggtggaa ccagtggttg
    48181 tgttgaaact ggatgttttg gtaaagaagc atatgttcta actggatata tgaacattcc
    48241 aaaaatactt gaattaacat taaataatgg atatgaccca attagtaaaa aacaaatagg
    48301 tattgaaact ggagacccta gaaatttcca atcttatgag gaactatttg aagcatttaa
    48361 aaagcaatta cattatatga ttgacataaa aatagaagga aatgctgtga tagaaaatat
    48421 atgtgcaaaa cacatgcctt gtccacttat gtctacaata gttgatgatt gtatagaaaa
    48481 aggcaaggat taccaaagag gtggagcaag atacaacact agatatatac aaggtgttgg
    48541 tataggaact ataacagata gtttaacagc aataaaatat aatgtatttg ataagaaaaa
    48601 attcgatatg gatacattgc ttaaagcact tgatgctaat tttgaaggat atgaagctat
    48661 acttaattta gtttcaaata agactcctaa atatggaaat gatgatgatt atgctgatga
    48721 aataatgcaa gagatattca atgcatatta caatgaggta actggtagac caactgtttg
    48781 tggtggagaa tacagagtag atatgttacc aacaacttgt catatatact ttggagaaat
    48841 tatgggagca agtccaaatg gtagactttg tgcaaaacca gtttcagagg gaatttcacc
    48901 tgaaaaaggt ggagatacta atggacctac agcagttata aaatcttgtg ctaagatgga
    48961 ccacataaaa actggtggaa cattattaaa tcaaagattt gcaccatcag tagttcaagg
    49021 agaaaaaggg ttagataata tggctaatct agtaagagca tactttaata tggatggtca
    49081 tcatatacaa tttaatgtat ttgataaaaa tgtactgtta gaggctcaaa agaatcctca
    49141 ggattataaa gacttaatag ttagagttgc aggatatagt gaccatttca ataatttaag
    49201 tagaacacta caagatgaga taataggaag aactgagcaa acattctagg tttgcttgta
    49261 aataaaactt cttactatat aaaatcgtaa ctgatataat aaagtataaa tggtttgatt
    49321 ccatttttaa aattttagat taattatgag ctaactttct aaataggaag ttagctcgtt
    49381 aagtttaatg aaaaaatcgt taaatttata tttagtaaat catacacata ttagtaagta
    49441 atacatacaa aagaataatt tattatagtt ataataaggt tatattttat aaaaataaga
    49501 taattttaag cagttaaaat aaagtcaatt tagctacttt aaaataaaac taatagaaaa
    49561 aaggagattt gatatgaaaa ctttaggatt tattggttca gggaatatgg gaagtgcaat
    49621 gataggtggc atagtacagt caggattagt aaaggcagaa gatataactg tatcagattt
    49681 aagccaagtt gccttagata aagtaaaaga agaatttgga gtaaatacta caactgattc
    49741 aaaggtagct gttacaaatt ctgatgtggt aatagtagca cttaaaccta atatatgcga
    49801 aaaggcttta actccactta aagaattaat agatgcaaat aaaataatag tatctatagc
    49861 agcaggtaaa actatagaaa gtctggaaag ttttataggt tcagataaaa aaatagtaag
    49921 agtaatgcct aatactccag cccttgttgg cgaaggaatg tcagctcttt gtaaaaatag
    49981 taatgtaaca gatgaagagt taaatatgat taaggctctg tttgaatctt ttggtgaggc
    50041 agaaatagta tcagaatatt taatggatac agttacaggt attagtggtt cttctcctgc
    50101 atatgtattt atgtttatag aagctatggc agatgcagca gtattagctg gaatgccaag
    50161 acaacaagct tataaatttg catctcaagc agtaatgggg tcagctaaga tggttcttga
    50221 aactggaaaa catccaggtg aattaaaaga tatggtttgt tctccagcag gaactactat
    50281 agaagctgtt aaggtattag aagaagaagg ctttagagca gcagttataa aatctattgt
    50341 tgcttgtata gataagtcta aagatatgag taaataacag atgtaattaa gtttactata
    50401 tggtttcttg aattgttttt ttagtgctta tttatatcta tacataaatg tatttggtat
    50461 aagtaaaata agagtaattt actataaaaa ggaatttaat gattgagtga gaatttatta
    50521 cttaaatatt aataattaaa tagatatatt tttaactata tttgagatat atcattgtga
    50581 aaaaataaaa tttataagta ttattgtgag gttataag
//
LOCUS       DAEPID010000025        48898 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.025, whole genome shotgun sequence.
ACCESSION   DAEPID010000025 DAEPID010000000
VERSION     DAEPID010000025.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 48898)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 48898)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..48898
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.025"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            44..916
                     /locus_tag="KR257_001557"
     CDS             44..916
                     /locus_tag="KR257_001557"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429584.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBH0030266.1"
                     /translation="MEMKIAVSNLSKRFGKKQALDNINLEIDSGMFGLLGRNGAGKTT
                     FMRILATLLSKTEGSIHMCGVPIENTKEIRNMVGYLPQDFSMYPNMTVYKAMDYLAVL
                     SDIPLRKRRKIIAKLLSKVNLTNYQNVKVKSLSGGMNRRLGIAQALIHNPRVLIVDEP
                     TAGLDPEERIRFRNLLCEIANDRIVILSTHIVGDIEATCENVAILNSGKVIYNGSTEA
                     LAKLAEGKVYSIEVDKKDIENIKSRFIVIGMLTHGGKAILRIISDDKPFETAVNCNPT
                     IEDGYMLIMGGDNI"
     gene            913..2202
                     /locus_tag="KR257_001558"
     CDS             913..2202
                     /locus_tag="KR257_001558"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429585.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBH0030267.1"
                     /translation="MNLFIKECKNILKSMIYYIFIVVLVFFYISQLGSSVSNDVSKNI
                     PNDGNPLVAPQKVENIEEYYSVHNQYPYGQKESMKTEKVIPNATINLIREYQKNTYTT
                     YPTGVVKYIKLDQNKTKTIEKYIEEITGKSISEINSLWKTDESIKIDYSKVSLERFEE
                     IMQRVDDILGGGSAYAFDKLQRFGVVPVTYDEAMKNYNYTIQKDKVSNGYARIFCDYI
                     GIVLSIFPVFVAVFMSLKDKRSRMREIIYSKQVSSCKIVLSRYFALVFMMILPVLILG
                     MKDLLPLIFFAKDKGISIDNLAFIKYTLWWILPTLMIVTAVGMSITILTDTPVAIIVQ
                     LIWWLYSINSTGLKGDYSTMGLMIRHNSVLNGDIIIQNFNQIMINRIVISLGALVLVL
                     LAIFLYEQKRRGNLDVWAKFSKLFSSNKRKLQIKHFN"
     gene            2132..2776
                     /locus_tag="KR257_001559"
     CDS             2132..2776
                     /locus_tag="KR257_001559"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903589.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBH0030268.1"
                     /translation="MFGQSFQNCLVLIKENFKLSTLTNLICSIILLCMIPLIQGVANL
                     DRISTAICLENYVAIIGIVMLVPVFSLEQSKEIDEIVSSKALSQVIVQLIRILMSIIG
                     IVVLIIGFVNVLIYLGCNFPVVEYIIGSFASAMFIGSLGMFFSNLFNNTIIGYMISIG
                     YLILNMMTKGKYVGKFFIMSMSQGSFDEKYWLILGSVVLIIASLLIKPVKRKIR"
     gene            complement(3043..3506)
                     /locus_tag="KR257_001560"
                     /pseudo
     CDS             complement(3043..3506)
                     /locus_tag="KR257_001560"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861860.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
     gene            complement(4506..5333)
                     /locus_tag="KR257_001561"
     CDS             complement(4506..5333)
                     /locus_tag="KR257_001561"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861859.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AIM24 family protein"
                     /protein_id="HBH0030269.1"
                     /translation="MDLSKKVKILENASDGKSEFEILEFEKLEGASSPLMAMGLYFAR
                     EAGLKARQIKIKLNNSSIKTEAGALYYYKGNISSETKIGGVGGLFKKGISGALTNESM
                     MKPVYKGTGEVYLEPSFRHYLFMSLDNDSIIVDKGLFYCCSDTIEVKAFTQKNFSSAL
                     LGGEGFFQIELSGTGVIVLECVVPQSEIVEYELKNGEELKVDGNFAIARTSGVNFSVT
                     KSDKSLIGSALNGEGFLNTFTGSGTVWLAPTQVMYEKLSFGAMPTNDNMNNKVSKQK"
     gene            5897..6352
                     /gene="smpB"
                     /locus_tag="KR257_001562"
     CDS             5897..6352
                     /gene="smpB"
                     /locus_tag="KR257_001562"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421925.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SsrA-binding protein SmpB"
                     /protein_id="HBH0030270.1"
                     /translation="MAGKKILATNKRARHEYFIEETYECGIELKGTEVKSIRQGKVNL
                     SDGFASVDNSEVFLKQVHISPYEQGNIFNVDSLRVRKLLLHKHEIRKLIGATTIKGYS
                     LIPLSLYLKNGKVKVEIALAKGKKLYDKRQDMAKKDAQRRIEREMTGKY"
     gene            6510..6859
                     /gene="ssrA"
                     /locus_tag="KR257_001563"
     tmRNA           6510..6859
                     /gene="ssrA"
                     /locus_tag="KR257_001563"
                     /product="transfer-messenger RNA"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00023"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: cmsearch."
                     /db_xref="RFAM:RF00023"
     gene            6974..9001
                     /locus_tag="KR257_001564"
     CDS             6974..9001
                     /locus_tag="KR257_001564"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903559.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SAM-dependent DNA methyltransferase"
                     /protein_id="HBH0030271.1"
                     /translation="MSIDNNFNHVAFLWNIAESLRGTYKEEDYRKVMLPLIVIRRFDC
                     LLDDYDREIIKSVYEEYDFLPEEERDELVIVDLKENHDINLQFYNVSDFTWKKLLDDS
                     ENIKSNFEEYLNGFSNNVKEIIGKFKFKDEINQLDKKDKLYAVLSKMYEVDLHINSVS
                     NNKMGYIYEEMLRRFTENSAAGEQYTPREVIRLCMEILFMGKENFLTEEGKVISIADF
                     CCGTGGMLSIAEDYVEKINPSAIVNVYGQELLDESFAICQADMLMKGQNPDNIRLGNT
                     LTQDRFNGEKIRFLISNPPFGVTWKDEEKKVKEEADLGFDGRFGAGTPRVSDGSLLFL
                     QNMISKMYDDEEGSRIAIIFNGSPLFTGDAGSGESNIRKWIIENDLLEGIIALPTDMF
                     YNTGIATYIWVLTNKKEAKRKGKIQLVNASEYYQLMRKSLGNKRKEISLEQIEQIKEI
                     YEKFEESENSKIFDNEDFGYRKVTIERPLKLSFKVNEEAIENVKNTTQFINLAVSKKK
                     DIEVKEKEEAEGKIKQDKLIKLLESFDNTLEYMDRDKFIKDLKAKSKEFDIQLSAGLI
                     KAIVNTIGVRNEDAEVCKDSKGNIESDSSLKDTESIGLKDDVYEYFEKEVKPHVNDAY
                     IDESSINNIGYEIPFTRHFYKYEELRSFAEIMKEVESLESEIALKIRKVLG"
     gene            9001..10392
                     /locus_tag="KR257_001565"
     CDS             9001..10392
                     /locus_tag="KR257_001565"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010233411.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="restriction endonuclease subunit S"
                     /protein_id="HBH0030272.1"
                     /translation="MGYRYRSDDELKDSGVEWLGKIPKDWEVRQLKRVLSDRKENNEP
                     IKTSNILSLTIEKGVIPYSEKGTGGNKAKEDLTQYKLVYPNDIVLNSMNVIVGAVGLS
                     KYFGCASPAYYMLYKINANDDIRFYNYIFKSKLFQDSLKGLGNGIMMKQSETSGKLNT
                     IRMRIPMEKLSSVKIPIAFNLDQEKIANFLDEKTSQFDSIISKKEKLIERLEEAKKSL
                     ISEVVTGKVKVVKTDDGYELIKRSSEEMKDSGVEWLGEIPKEWDIKRLRFLGKLQNGI
                     SKSSDSFGYGYPFVSYSNVYRNIELPHIVEGLVNSTEEERKIYSVEEGDVFFTRTSET
                     VEEIGFASTCMKTIDNSTFAGFLIRFRPNDKRLYKGFSKYYFRCDLNRKYFVKEMNLV
                     TRASLSQNLLNNLSVVLPKYEEQVEIYNALELKVSYINLSINKLKYQIEKLKEAKQSL
                     ISEAVTGKIEILD"
     gene            10454..11725
                     /locus_tag="KR257_001566"
     CDS             10454..11725
                     /locus_tag="KR257_001566"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0030273.1"
                     /translation="MDKNIFQININTDVLIRLRNQINEEYYISYRKEFYDKNNKKHRA
                     WDKICAIMDRLDDTVDYLNKLKLNTGKYRRSAFDFFEFMNQASVVMDCITHLAKIFEV
                     PYEEVETSTEIFNELGKEGKGTDKKYFEYLRSLCSVHPMETSRHKIYQENSFECSPYV
                     VWNDKSIWTNDASDLYAVVYTSKDNDSFKRIHIYMNQIFEYVKRRVNFIENIIEHIEK
                     YQQEIIEIFRNTPIKKEEDFESYIDYLRNLKKEIEIRYGNDSFHELNYLIELFDLPLS
                     NPDNEEKMNLYKNALKYAIKFEHNSIQNMTNEGYKNNGILYPQVNITTTLLEELISLN
                     SGSEERRKYRYAIEKTSYLSYDSCWSDREWAYDQIDDMMPFLERYVTFDKAQSDFEHY
                     VLVKLALYLECLENECLINKNVPNDKKFRIK"
     gene            11760..14741
                     /locus_tag="KR257_001567"
     CDS             11760..14741
                     /locus_tag="KR257_001567"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903553.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type I restriction endonuclease subunit R"
                     /protein_id="HBH0030274.1"
                     /translation="MLPKEKHLEESIENHLVSIGYEQGHSQEFDLENCLFVDDLFRFL
                     ENTQKELLDEFKYNRGSNYKKAFIDLLNSNIKRRGLISVLRNGVEDIMMNGKFQLFYN
                     KPNLTTNKTAYENYKQNIFKITRQLKYSSKHNNTLDIVLSLNGFPVIVMELKNQFTNQ
                     NVYNAIKQFKKDRNPKETLFGFNQRVLVYFAVDTDEVYMTTELKGDKTFFLPFNKGNN
                     RGKGNPVVEGKEKTSYLWEEILTKDSLLDIIKRFYFIQEDDKGNQRAIFPRFHQLDAV
                     RKIVEDLKINKVGKNYLIQHSAGSGKTNTIAWTSHRLSSLHDEENNAIFDSIIVVTDR
                     KVLDKQLQNAIYQLEHKNGLVVKIDEDKNSSDLADAIVNRAKIIITTIQKFQYALPKI
                     EQLDKRRYAVIIDEAHSSTSGENMNALKETLAGKTLEEAKVIDAENEKNEKSSIDKMN
                     ELIEKRTNLGNISFFAFTATPKNKTMQVFGRIGEDGLPHEFHLYSMKQAIEEGFILDV
                     LKNFMPISVYYKVGKKIIDNPEFDKGEAKRAINKFVSLNEHNIRQKVETIVDDFVDNR
                     SMWLEGKAKGMIVTASRLHAVRYKLAIDQYIKEKGYDMKALVAFSGTVKDGDDEYTEV
                     GMNKEVAPDITDSNLPNIFDKNEFKLLIVAEKYQTGFDQPKLCAMYVDKKLDGVKTVQ
                     TLSRLNRTYPNKQTFILDFQNSVEDIQDAYKPYFEMTNIDKVTDPNVVNDLWYQLHEY
                     AVYTDEEVNDFTVLFYKEKRTSSQDAKMNNLIDKAVERYCYLEEDDEKKSDEFKKKCQ
                     KYITFYNFLIQIYPIKNLNLLRLQVYLVALLKKLPKKSKQRIDLDDMLSLDYYKLQKL
                     GLDDKKGTDISLYNGEGELVGISETATSRVSEADEEYLEDIIKKINDVFGVGLTEDDR
                     IMINTYEEMFKNDKDIMDIAKANSYEDLVSTFGKKYFKRGIVKTKNRNDRLVKEILTN
                     NNLQNYMIHYLAEKIYEEANR"
     gene            complement(14800..14970)
                     /locus_tag="KR257_001568"
     CDS             complement(14800..14970)
                     /locus_tag="KR257_001568"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0030275.1"
                     /translation="MNNDKPFIEFEEEVDFILTECKKEGVSIDRDTIELILDLDLKFL
                     ELKGIATPLEDE"
     gene            15251..15586
                     /locus_tag="KR257_001569"
     CDS             15251..15586
                     /locus_tag="KR257_001569"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003427594.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0030276.1"
                     /translation="MIKLWKKEDLNLLLEYPKEVVENVDNVINILDENYGCNRKLTDD
                     GGYVCIIEDIKEVENLKSNILKGLVEEFSDVIYEDEVNTYNSTLYLLSSDYSVTVISK
                     NEETEYLLK"
     gene            15650..16108
                     /locus_tag="KR257_001570"
                     /pseudo
     CDS             15650..16108
                     /locus_tag="KR257_001570"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003427593.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="JAB domain-containing protein"
     gene            16248..16541
                     /locus_tag="KR257_001571"
     CDS             16248..16541
                     /locus_tag="KR257_001571"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903547.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0030277.1"
                     /translation="MFKKENRYMTKEIAENLPIEIAILLWNLIDDLTTEKDYLQLFEI
                     NPIGLGVVEIVHKQEVPEYEARIYIQNDKIKDKLKIYVIDNVEYRTMMFSNEY"
     gene            16568..17164
                     /locus_tag="KR257_001572"
     CDS             16568..17164
                     /locus_tag="KR257_001572"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903546.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0030278.1"
                     /translation="MINNKSEIINKLFFNELKELIDKYNNIDDKTVDVIEKIFTCIED
                     EEIKNYLIRDNCKLQELVNTYNKLEDLNIDEAIFFAWYNLTINTISIDKASEYYDDLT
                     TSNYIEVENHIIYTNERDLRKYAEDELETMLSMEHHIDRLLHKDMLIDMWLNNTSKEE
                     VIEEILMSDDIEDILNLSPEYAFTLANGIEYRYSEKEE"
     gene            17317..17586
                     /locus_tag="KR257_001573"
     CDS             17317..17586
                     /locus_tag="KR257_001573"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003487728.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Mor transcription activator family protein"
                     /protein_id="HBH0030279.1"
                     /translation="MTNNNNNCDYKGIYADMVEVLGEEIVIKLHKYYRGQQITFPMKL
                     YSIEYVERYIVKNYRTKTIKEMCRELGYTEGWIKQLINKNRLNSK"
     gene            17612..17854
                     /locus_tag="KR257_001574"
     CDS             17612..17854
                     /locus_tag="KR257_001574"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0030280.1"
                     /translation="MILTVLAILMGTGIFFLINSMLDITYFGCGPIGFLWFGCFIVSY
                     AILTSLGGIVLGLLKWIVIGLIILFVIGLIANKIND"
     gene            18060..19193
                     /locus_tag="KR257_001575"
     CDS             18060..19193
                     /locus_tag="KR257_001575"
                     /inference="COORDINATES: protein
                     motif:HMM:NF012938.1,HMM:NF016983.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosome-binding GTPase"
                     /protein_id="HBH0030281.1"
                     /translation="MQDFDFISETIKKFQSDLENMDKVNILVVGKTGVGKSTLINNIF
                     REELAETGIGRPVTQHLKKISKEGLPINLYDTKGLELEEDVQETIKKEILDEIENCNR
                     NSLERNDKSELMHVCWYCINTSVARCEETDIKWINELSEKIPVIVVLTQGFPRKKARE
                     LKSSIDDLNLNCKNVIPVLAEQLVEEEDEIVIKSYGLDKLVEVTYQVIPKEVKKAFVN
                     VQKVDIKKKVEESRKWVLGYVGGSGAIGFSPIPFSDAPLLATAQVAMISHITVIFGLQ
                     VDKALLTAIVSSIGGVTSATLLGKTLVSNILKFIPGAGTIAGGAISGSVAALTTTALG
                     MAYISVLEYILNENMKGNEVNNTEIAEKMKDAYKDQLGMLSKK"
     gene            19957..20202
                     /locus_tag="KR257_001576"
     CDS             19957..20202
                     /locus_tag="KR257_001576"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003427578.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0030282.1"
                     /translation="MRSVTVEDGDERFAIEKIYIKSLQRYEVRICLYRDCRDRINKLI
                     PRPVDLTMDKFVALILVGLKAGVLDDDFKQELIKGLA"
     gene            20550..21911
                     /locus_tag="KR257_001577"
     CDS             20550..21911
                     /locus_tag="KR257_001577"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0030283.1"
                     /translation="MKGNINKKDIDLSKITFDKFLEDEGLQNRERDYLYVDDYDNTLD
                     TQEFKLHIIEENTDNTYIDKDKYWYLDLDDSLFEYEEDEDTIAKTLYSLIDIRIKFLK
                     HVEYRKYINLGVIDEEYFDEIKSFLKFYIVAKTKKNELGNSNLKQMAIDIFDKERFED
                     DISDDDMENISEWIGEDQNFKMFYDKVCRDLSNSTQDKEILKLAGIRNNKVKHYKGRK
                     ISRKCKLELKSLTKMWEYETKLTHDANKAHKKIKSNMLEKMTDKNYKNIYEYLNNEII
                     NSNEEYKNIYFYSLELKLANELRKCTLKNLNKIKDIENQVKFISYTIAYIHIVPVLTI
                     REKLSDKLFNILSTNEGKDIEKFTKEVSLIMRIINIECLELLNIVSKNNYYKNFSEKE
                     LEEFKSIYNINNGRKSFENKYKIKVDYNIDDVRKYGEVIKAINIESKKKIVDRIKKKR
                     KSN"
     gene            22101..22418
                     /locus_tag="KR257_001578"
     CDS             22101..22418
                     /locus_tag="KR257_001578"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0030284.1"
                     /translation="MTNFKSVKVELILLIECEEGNRNELEGMIDEGVLNEKEYSLTIL
                     GSTEYEDNARAIYILMNTGGSYEKNLQRLSRLHLKIENLLKDTNVKYRGISLVPNIVK
                     WDK"
     gene            22430..24193
                     /locus_tag="KR257_001579"
     CDS             22430..24193
                     /locus_tag="KR257_001579"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0030285.1"
                     /translation="MSKAINREELIKLYEEIGLNVLDNNTVMNSSNKKICNFLVNIIE
                     QRVIDGKMYLCINAMGINGELLSEVILDSNTINRTTWVIENWGFKYSIDKKYINDFIE
                     LIQHLCMNIKTKYIYDHTGWIYQDNKWIYLHGGGVIGGSDVQVELDESIDNYILPDKI
                     SDINKACEMSLKLVDLIEDDKGIIFSSLVYLSPLIEIISRKIKPPENIVWTYGKTGSR
                     KTAVSKVVLSHFGDFNKKIPATFNDTITAIELKANKLKDSLYLCDDFAPKQDFRDKKI
                     QDSKAESIIRMYGDRVGKGRSSNKLDIKDAKRPRGMILITGEDVICGESSNARLLSIE
                     LNRSSVDLNILTELQNNSHLLGEAMRGYIEWLLSEMGNIDELSNILLYNFKSYRDEIR
                     EQYKDDIHGRTIESSAWILVGFSCMLNYIRDKGVIDKYEDDEYMDRAIKVVERLIEEQ
                     IKLISRNSPIDIFLNTLKESINSKSIRIATLNDQNQVIEDKLEYICGYKDKEYYYFYT
                     DKVYSFIEFENKKRGIHLGISQRQLVKQLRDSGIVKVDSNNDSPKKTIHTKDASDSTG
                     YTTIRPRMLQIERSIIENFQI"
     gene            24256..24411
                     /locus_tag="KR257_001580"
     CDS             24256..24411
                     /locus_tag="KR257_001580"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003427558.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0030286.1"
                     /translation="MTETYKISIGRKDLYSKDYKVVERTDYEKRHTVNISRSLVDILS
                     ILVKEDR"
     gene            24498..26063
                     /locus_tag="KR257_001581"
     CDS             24498..26063
                     /locus_tag="KR257_001581"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003427556.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
                     /protein_id="HBH0030287.1"
                     /translation="MTGKKAVVYARFSSDNQRDESIDAQLRAINEYADKNNIKIVNQF
                     IDRAKSATSDKRPEFQNMIKFCEADTTGISMVIVHKLDRFSRDKYDSAMYKQKLKVKG
                     IRVVSVLENLDNSPESLILESVIEGMAQYYSANLAREVAKGQKENALKALHNGGDAPL
                     GYDVAHDKTYTVNEEEAQAVKIIFDRYIKGYSYSKIIDELNILGYKTKRGNKFGKNSL
                     HGILNNEKYTGVYVFNKTQRKGVDGKRNGHKQKSEEEIIKIEGGMPQIIDKGVFKQAQ
                     DMIQKRKKTPGAHKATTTYLLTGLIKCGECGHAFQGNKRKDSYGNEYVSYRCGCRKQK
                     RECNNREIKRDYLEEFILQELEKNILNDEAIPILSKALNEKLNDKNESNAELLKNLEQ
                     KLDKVNKEISNILNAIMNGIVNSMLKDKLDELEQVKFNLDLKMNELKIENKVVDGVGV
                     TEDQIRGMFSRFKEFVLERNIPECKKFIGDYIKEVIVYKDHIEVIFNVVFCFVDNDIT
                     HDLHIITERGKIT"
     gene            26209..27501
                     /locus_tag="KR257_001582"
     CDS             26209..27501
                     /locus_tag="KR257_001582"
                     /inference="COORDINATES: protein motif:HMM:NF014177.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA adenine methylase"
                     /protein_id="HBH0030288.1"
                     /translation="MADIFTVLNYQGSKKRLLDFIYENTQEYIDSDKAFLDICSGTSA
                     VAYNMKRHFTVYTNDSENYAYQISNSIVKNNERYNFSQSDEMIIREKYNINLQRLNNI
                     FNDMVNQEDMLLEQEDADGLIELYSNCPCIWKNNVDIEIEGNTIQSIYDLRKCKRDIP
                     NVLFTLYYSSSYFGIKQSMEIDSIRYAIEFIESEITKSILFTSLFFAMKECVFAKDGH
                     MAQPLNMETGKKRMLRLKARSIYDIFIDKLKEFNTEEFVLSQKENKCFNKDFRTLLET
                     EESIKDEVGFIYIDPPYTDMQYSRYYHILNTVVLYDYPEISLSRGTISKGIYREGRYQ
                     SPLSQRKHALNEIDFLFSFCKENKINVALSYAYPIDTEKQATNRYTASIDDLINVAKK
                     HFGDNVKVVHEEYSHANNRNSDKKNVLEYLIMGIHNKE"
     gene            27504..29123
                     /locus_tag="KR257_001583"
     CDS             27504..29123
                     /locus_tag="KR257_001583"
                     /inference="COORDINATES: protein motif:HMM:NF013704.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA adenine methylase"
                     /protein_id="HBH0030289.1"
                     /translation="MDKINKLKERIANIEATNKNDIYSSNLYWSQKPFNICDEIIEHL
                     SEDGDIIFDPFMGSGVTVIEALKKEYKRNAIGCDINDAPIFIVKTLLEKYNVPKIEKD
                     IKELNNKLSKLSTYYSTKCRECGEVVTISKTIFDKENRNAKCELKSIHYKCKECKNDF
                     KGEPNETEISKFFIDEELKNIDDFQFIANSRLAVGEGDTVRTIFSNRNLIVLDKILGH
                     IDEYKNSESYEPMKYILLSILHLSKITDTHSNSQWPLWIPKKDCVEKNVVELFIKNSK
                     KTIKALKLASKYLCENRENVELIKNLDRGKFKLIKDGVQNIEDDVIPNEFVDLIITDP
                     PYMGQVLYSEYMQLYKPFMDLEFELENEIVISSAPARDKGKVLYFDMMNSAFENISRV
                     LKVGKYMCMYFHDSNLDVWDNIIDIMTNNNLKYMGQIHVSKNKNTLKNILSPKKSLNG
                     DCIIFFKKDLNINYDINEVDNIEDKINNIAQAIIDIKGYASTPELYDNGALEYIISNG
                     KLKEISKKYKDLTSIFEQRFNWDKERGVWTV"
     gene            complement(29248..30399)
                     /locus_tag="KR257_001584"
     CDS             complement(29248..30399)
                     /locus_tag="KR257_001584"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0030290.1"
                     /translation="MKKLTIRLKDDFHKDLLDLVAFKNDSINSYVINLIKNDLSKNTN
                     LLRSYDNMIRDNITNVLITQKINELKAIQDGIFKEYKVNDILSNSKIYEVMTANSLNH
                     ILIPGHSGSRDAKDEFGNEFEYKHFKKSSSNHSWTFNDFSDTSIAKLKKAKAVIFAHI
                     NDVDFPYPGKLDWYYSIPGDIMCEYLLKYTQSIQNSRKMINVSPNQLESRLNASKIIP
                     SAQNGVYDKYLSAIYKASSELEELTGVKNLLTSNKFWELIVALELNHQVNPEQGGREG
                     AHDAYDSEGNPYEYKVSKNHAWNFQDISDNVLNKYYNDKAIILAVVDKENIEVEHIYS
                     TEPADVVPLLRKKLQEKINRCLEKGSPIRRLQVSLSKSDLTRVNAKKLY"
     gene            30905..31120
                     /locus_tag="KR257_001585"
     CDS             30905..31120
                     /locus_tag="KR257_001585"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891555.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3791 domain-containing protein"
                     /protein_id="HBH0030291.1"
                     /translation="MDERKLEFSIFCIEALAEKLNIDSEGVYKLLKHDTDILDNYIIP
                     CYEALHSQSKGYIVEDLMQVLKEKGVI"
     gene            31120..31599
                     /locus_tag="KR257_001586"
     CDS             31120..31599
                     /locus_tag="KR257_001586"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003433745.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3990 domain-containing protein"
                     /protein_id="HBH0030292.1"
                     /translation="MIVYHGSYCVVKTPSITFSRDSLDFGKGFYVTSIKTQAINWTER
                     FKKRGKKAYLNSYSLDIDKLKENCKVKIFDSYNLEWLDFIIECRNMSDIYMKYDIIIG
                     GIADDKIYNTIELYQDNLIEKDEALKRLKYYKPNEQICITNQNVIDKYLKFRYEEEV"
     gene            31605..31835
                     /locus_tag="KR257_001587"
     CDS             31605..31835
                     /locus_tag="KR257_001587"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003433747.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0030293.1"
                     /translation="MEANKTLLQILYKKIILEFSKQTGKSLEESMDYLYTSETYKLIS
                     EGVSDMHCKGHIYLAQELMLENGLMYHKGYPR"
     gene            complement(31951..33117)
                     /locus_tag="KR257_001588"
     CDS             complement(31951..33117)
                     /locus_tag="KR257_001588"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861856.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="site-specific integrase"
                     /protein_id="HBH0030294.1"
                     /translation="MATKRANGEGSIGKYKDGWRSRIMIGYNEDGKPLRKEFYGKTQK
                     EVKDKLDAYKKQYYLSSDISDDKITLEHWFYNWLFEYRIKDLKPKSFERYESIYRNYI
                     KDTDLGNVKLKYLRVSHIQKYYNRLLDSNKSIPTIRQINTKLKTCLSEAEKQGLIQRN
                     YCTMVNIPVEKKENKLEILTLEQQKSFIKAIDGHKLEVLFLLALGTGLRLGELLGLKW
                     FDIDFKKSNLTVKRTLQRTYFIDKTGNRELKVLEQGPKTSNSYRTVPIPKDVLNKLKE
                     HKVNQNTDILKAGELYINNNYVFCNELGIPIDDKRPLRNLKSILNSLNIEPIKFHGLR
                     KTYATRLFENDVPPKTVQVLMGHYDISITLNIYTQVMEDKKVEAVEKLDKIFSL"
     gene            complement(33107..33859)
                     /locus_tag="KR257_001589"
     CDS             complement(33107..33859)
                     /locus_tag="KR257_001589"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898282.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Fic family protein"
                     /protein_id="HBH0030295.1"
                     /translation="MNKSYIPKYTHKFPTNIPHGDKKYTLTYIRRMISEFVYDMGNLE
                     NNPFTFPEVQTLLDGITVGGHKLSDQNQILNIKSSWDYVIKLSNKENLSLNKDTICSI
                     HKIVAKDEALIVGDFRNGNIGIAGTTQYECIEATLLNDLFVNDINIINKITNPLEKAI
                     IINLWLSYCQFFYDGNKRTARLTSNLILINNDIGVLSIPAKHKQEYNTLMLNFYETLE
                     ADEVIKFLLEKCITFFDGYNYKSYKELFKNGN"
     gene            complement(33951..34442)
                     /locus_tag="KR257_001590"
     CDS             complement(33951..34442)
                     /locus_tag="KR257_001590"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891546.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="HBH0030296.1"
                     /translation="MMNNTIGEKIKQYRKSINMSRDELANKIGCSVHAIAKYEQNQRM
                     PSLDMIRKIATALSIAINKLIVEENDLDTLTNNNINLKVFDKELDLVIHILENYGYDI
                     KTDYKKKFEITDNADTIKPINLNFSDFKDFSKNLNWVINGLVENFIQENSNGLIEDED
                     EEY"
     gene            complement(34439..34637)
                     /locus_tag="KR257_001591"
                     /pseudo
     CDS             complement(34439..34637)
                     /locus_tag="KR257_001591"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729178.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
     gene            complement(34694..35455)
                     /locus_tag="KR257_001592"
     CDS             complement(34694..35455)
                     /locus_tag="KR257_001592"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729177.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HBH0030297.1"
                     /translation="MQIGKNLKKIRKQKELTQIQLAEISGISRNALINYENDKRIPSI
                     DTLSKLAKALKIEKTIFYFDIENEVMTNEDVLYLLQSLFPEEYYSFDEFLNAISNLME
                     DDIRITSSLLLGAWSDKDQYYKLGEKLELNENQVYNWILSDCISNTELDFSLHPDDIK
                     EIIKNDVLTKQSIDELLDIGLSEESIETIYDYFSDSTDNGSNIRLKKLISQKENITIK
                     NNDYFKLLQENNELKEKNEKLENTLKEIKKLLTKI"
     gene            35602..35802
                     /locus_tag="KR257_001593"
     CDS             35602..35802
                     /locus_tag="KR257_001593"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891540.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HBH0030298.1"
                     /translation="MGINLKIFRIKKGLKQQELADRVGISRYYLSNLETGKANNPSND
                     LMIKLSRALDTTVEELFFSKED"
     gene            35806..36120
                     /locus_tag="KR257_001594"
     CDS             35806..36120
                     /locus_tag="KR257_001594"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003433761.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0030299.1"
                     /translation="MKENNNLEVLKTLQATLNIIVKNEEEAQEKKQGYKIIENAKRNK
                     AELITCKEASKLYPIGESKFRQLCHSKNKGFPCIWINNRVYIIKNKLDDWFIENANGI
                     KL"
     gene            36142..36885
                     /locus_tag="KR257_001595"
     CDS             36142..36885
                     /locus_tag="KR257_001595"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729175.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0030300.1"
                     /translation="MSNKGWIKLYRELLDKSIWKDIKPERKVILITLLLMASHKENHV
                     FIDNKKIKIKFGQFISSYSKIAERCGKGVSYQMVRSCLLVFKNAGFLTYETTNKYIVI
                     TIENWELYQENIENQQPNQQTINNQSTTIKNIKNENNIIYSEIISKFNSTCIELSKVK
                     KLTDTRKRRINSRIKEYDKETVLEVINIVSKTSFLNGNNNTGWKANFDWIMNSSNFTK
                     ILEGNYNSKEIVINKETGIYNPDDSQLKW"
     gene            complement(37591..39504)
                     /locus_tag="KR257_001596"
     CDS             complement(37591..39504)
                     /locus_tag="KR257_001596"
                     /inference="COORDINATES: protein motif:HMM:NF020926.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1998 domain-containing protein"
                     /protein_id="HBH0030301.1"
                     /translation="MSIKLDDKTHNLRINQATSVFGPGAMLDFIDQTLMTAHPNYWTN
                     TIKIQDDRLQATLRVNELRTPPTIDDRSSVPFVRFPRWYFCPKCRKFMPIEDWEKLYK
                     NAHKDKPMKIPICLTCSTKKSTKQLVPTGIITICEHGHIDDFPWVKWVHFRNKSGRKE
                     ICENPQILMKTGKSNLGLEGIELECSCGAKANMKGAFMRLKSSKSNDYGVPSEYKEMF
                     KCSGNSPWYNKKVNKCTKYSFASQRGASNVYYPKIESSIIIPPYSDTLNSKVLSSKGY
                     DTFKKFLDRAIKKNKLERFMDEDFEDFASDIAKETGFDTDKVSIVLKDLLPFEDSSPS
                     TTTRNQYREEEYEALIGNIDAKSKKTNDFTIEEQNLSDYDIPNFSKIVLVKRLREVRA
                     LTGFSRVNPPDNNIFGEEDIDDSCNDTKVISLRSRDCKKSFYPASEVRGEGIFIEINN
                     DMVKSWISSNPKIQDNASILNSRYNKDINVNDKAYRKITPKFLLLHTLAHLIIRELSF
                     VCGYATSSLRERIYCNNSENEKVMSGILVYTASGDSEGTLGGLVRQGMHDSLPSILNS
                     ALNRALWCSNDPICIDSTGQGRNSLNLGACHSCTLLPETSCEEYNLLLDRSMLIGDMD
                     NRDIGFFKNLILI"
     gene            complement(39506..43033)
                     /locus_tag="KR257_001597"
     CDS             complement(39506..43033)
                     /locus_tag="KR257_001597"
                     /inference="COORDINATES: protein motif:HMM:NF012493.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helicase"
                     /protein_id="HBH0030302.1"
                     /translation="MNCSELRDKTLDLVRKELLGPGSEDLCENIKYEIITDSPIERYS
                     TGILYPLNNNIDVSNTSEYDGEDNVFTSDDTQNELDRAISMSNETLPSSMGMTFFLKK
                     DAEVINFRVNYATYRNALYTDCHVKYTGDDFYSSNTINEYVELRGSFLYLKQKLTSEK
                     VYNLLKKHDLLDNAEAKFVLYKLANQCPDDENKTGGYVRVPHENLIVSIDMDKNYIKK
                     PISKDLDIVLSKRIYSNDFVSITCMLVNSQSGPKKYNNTIFQPELMVLAEDNNDLEFI
                     DIFTAGSVNTFKKLDSEEISLDLLYRNKKTFATGHGVAIDQDIQNDALIKLCTEFIPH
                     FEVPKLDFNVDELSDVSRELLSMKNLSDISDLSKDKKIYFLYKFVDAYDIWIDDLEED
                     SKDLSDVFKDVAYEHIKNCRDTKSRMLEGINLIKSNDEVYRAFSLMNRAILMQRCHSI
                     HITDRLPGSNNLDYIDYSNDNSAWRPFQLAYILTCLSSIENPDSKHRDLVDLLWIPTG
                     GGKTEAYLGLSAFTIFLRRIRNKENGNGTAIIMRYTLRLLAAQQFIRASILICACEII
                     RKENKSELGKKEISIGLWIGSDQTPNFNDEAEEMLNNLTGNNIKFRSSINSEYELDNL
                     KSKYNKFQLLKCPWCGTKLVKEWDKTSKKAVGDWGYRIKSRPKKFYLCCPEEDCSFED
                     MLPIQVVDEEIYNNPPTLLFGTVDKFAMITWTTEVASLFALDDDNSNLSPELIIQDEL
                     HLISGPLGTMVGLYETALDAMCSYKGIKPKIIASTATIRKAQNQVKNLYNRNVAQFPP
                     PGLTSSNSFFVKEMPLSKKRGRLYVGVIPSGKTQVTVEVRLMSALLQRLKMMENVELN
                     LLDKYWTLVSYFNSIRELGKCSTLLNDDIKDNMERLCKRVSAHPYQSLRNLNEQRELT
                     SRLTSTKINTTLDELSNTLTSNNLTVDTLLASNMISVGVDVDRLNLMVVVGQPKLTSE
                     YIQASSRVGRSNEGLIFTLYNPTKTRDRSHYEQFFSYHQSFYKFVEPTSITPFSEPAR
                     ERGMHAVLISMIRHILGLQANDLASRFSKNMDGVEDLKNFIIDRSIDIFRENNQNADD
                     NIVNEFKSEISSELDIIMDLWHDKAQISDKDNLLHYYKRPSKFDNKIYNNLLIPYDKD
                     VITNEKQTLNSMRNVDKQCTVEIIELEEN"
     gene            complement(43051..45669)
                     /locus_tag="KR257_001598"
     CDS             complement(43051..45669)
                     /locus_tag="KR257_001598"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0030303.1"
                     /translation="MLTTNIHYILDNDICEIYFNKQRLTNSKYYQDNINVLNYIINEK
                     NNNLIINYNDKYIYAIYLLNIAINSYLNNTLNPNNHILTKLDKGMPLLYKGQIVIFKN
                     INNTHITLGHKNKTDTTLIPIDSAYMLITYNGHLEVNSMGKTPASKTFQTKNVLSSLG
                     FSDLKNMTGVINDSTLIILPCKDDISDLVSNIKIKDINNTYKFTELFPCSYISSTGAE
                     TDYPGNHAKQIPLLKFTTNISSAFEIIKSDKSIKNVFIIGDYPIYKHINDFERILNRK
                     RIESVNIVTSNSNISNILDLPNIDNLNIYSWSKDVLLTYSQDFENTSTFQKLWLDKLI
                     NKNICTTSVDSNISDLIHQARKSLYYISKYDFDISIKNSLMMCSYSLLKILENTPFNL
                     DFLEETIKLLNLNIATPSAKLENIKYLISSTSPDLELSALFDDVIVKFERIINELSDN
                     NTKFNTLNKLVSSYKYKTFTPNTPVILLQKQYEAIILKNLLKSRNINLQVISAEKFKD
                     SKTIKNLIMFGFYDLKYLDILNSDLIINITLYLYNSELSKYNYYMNQINSARNKIEKN
                     NKIYNLLDIKPFKPTYETNKLEAYSTDSPISDDDSMDEYISNYKFDINLNEIILSLSI
                     NQGIYNSKKEHVTSFMISDNNEYIFCTKKAIAYSIDWDKKSVRKKKLSEAKVNDWFLF
                     VDDYLNEEGELVINVIQKLLELNLLPSHYLDDYKLTNSWKSELKNYISYSKYNYNDVS
                     NSLAVLGEKINPITIKNWVTNKRLIGPIYLKTFEKIFKVIDSKLDHTEVYDATKSIRS
                     LHTKIKKSIDTFVSDNFFSSKSDIIKDEVSAVVLSMLGNTNDYVTPVQIREIHSCDKY
                     LSPHLVNKVLDLYSVY"
     gene            45981..47606
                     /locus_tag="KR257_001599"
     CDS             45981..47606
                     /locus_tag="KR257_001599"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012100074.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA cytosine methyltransferase"
                     /protein_id="HBH0030304.1"
                     /translation="MYNVIDLFAGAGGLSLGFEMTKKFNMVAFVEKNDNAAKTYLENH
                     PSVKRYCDIKRLDFQDILNSVDKIDVVIGGPPCQGFSNANRQKRKIINGNNELVKLYV
                     DAIDKLKPNVFVMENVKTISSNKHSFYLTKKDKNHIINNLKLNIYNKDSVLYDRTEYI
                     NELFNIISIEDIESYIISNIDLKNLKIIIKKKKDICDYLNKISNYKKVKSTIEKLETR
                     GKMPKWYLELINKVKNILENMLYNRNLSDEQIFYLNLFLDIQNLFLGIYELKSESVIF
                     ENTLDDNKIIAKMDTYIIIDYINASFEYLGYVLNGSALNSIDYGVPQNRERFVLIGAK
                     KDFLKNKKIETPKPIVGENYVTVRDAIGDLAEYEASKGSMDYCFEKNSNNIEKDFYRK
                     IILDSNKIYNHVCTDTRNIALKRFEYINQGNNFHSLPDELKGTYADPERTQNTIYKRL
                     VYDKPSDTVVNVRKSMWIHPIKNRAVSAREAARLQSFPDSYKFLGTKDSVYQQIGNAV
                     PPLLGRVVAEKILNLFNDEPNEYLRDVFEALDG"
     gene            complement(48606..>48898)
                     /locus_tag="KR257_001600"
     CDS             complement(48606..>48898)
                     /locus_tag="KR257_001600"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003427525.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=3
                     /transl_table=11
                     /product="class B sortase"
                     /protein_id="HBH0030305.1"
                     /translation="LPLGSIFMDYRNNFENDKSLIVYGHYMKNKTMFGQLENYTDEVF
                     FKENNLVEINYKVQTYTYEIFSVYTADLINRDYLSIHFNNNDEFKYSLNYIT"
BASE COUNT        19306 a         5464 c         7517 g        16611 t
ORIGIN      
        1 aaaataaaat tctataaaat tgtttctggg ggtgtattta tatatggaaa tgaaaatagc
       61 agtatccaat cttagtaaaa gatttgggaa aaaacaagct cttgataata taaatcttga
      121 aatcgacagt ggtatgtttg gtcttttagg aagaaatgga gcaggaaaaa ccacatttat
      181 gagaatttta gccactttat tatcaaaaac agaaggttca atacatatgt gtggagttcc
      241 tattgagaat actaaggaaa ttagaaatat ggttggttat ttgccacaag acttttcaat
      301 gtatcctaac atgacagtat ataaagcaat ggattattta gcagttttat cggatatacc
      361 actaagaaaa agaagaaaaa ttatagcaaa gttattaagc aaagtaaacc ttactaatta
      421 tcaaaatgtg aaagtaaaat ctttatctgg aggtatgaat agaaggcttg ggatagcaca
      481 agcattaatt cataatccca gagttttaat agtagatgag ccgacagcag gtcttgaccc
      541 agaagaacgt ataagattta gaaatttact atgcgaaatt gcaaatgata gaatcgttat
      601 tttatctaca catattgttg gagatataga agctacatgt gaaaacgtag ctatattgaa
      661 tagtggaaaa gtcatataca atggctcaac agaagcatta gcaaaactag ctgaagggaa
      721 agtatatagt attgaagtag ataaaaaaga tattgaaaat ataaaaagta gatttatagt
      781 tataggaatg ttgactcatg gtggaaaggc tatacttagg attatatcag atgataaacc
      841 ttttgagaca gcagtaaatt gtaatccaac tattgaagat ggctatatgc ttataatggg
      901 aggagataat atatgaatct atttataaaa gaatgtaaaa atatattaaa gagtatgata
      961 tattatattt ttattgtagt tttagttttt ttctatattt ctcaacttgg aagttcagtt
     1021 tcaaatgatg taagtaaaaa tattcctaat gatggaaatc cattagttgc tccacaaaaa
     1081 gtagagaata ttgaggaata ttactctgta cacaatcaat atccatatgg tcaaaaagaa
     1141 tctatgaaaa cagaaaaagt cattccaaat gcaactataa acctaattag agaatatcaa
     1201 aaaaacacat atacaacgta tccaacaggg gtagttaagt atataaaatt agaccaaaat
     1261 aaaacgaaga ccatagaaaa atatatagaa gaaataactg gtaaaagtat tagcgaaata
     1321 aattcacttt ggaaaactga tgaaagtata aaaatagatt attctaaagt atctcttgaa
     1381 agatttgaag aaataatgca aagagtagac gacattttag gaggagggtc tgcatatgct
     1441 tttgacaagt tacaaagatt tggagtagtt ccagttacct atgatgaagc tatgaagaat
     1501 tacaactata caatacaaaa agataaagtt agtaatgggt atgcaagaat tttttgcgat
     1561 tatataggta tagttttaag tatatttcca gtatttgtgg cagtttttat gtcacttaaa
     1621 gataagcgtt caagaatgag agagattatt tattcaaaac aagtatcttc atgcaaaata
     1681 gttttatcaa gatattttgc acttgtcttt atgatgatat tgcctgtatt aattttaggt
     1741 atgaaagatt tacttccttt gattttcttt gctaaagata aaggtatatc tattgataac
     1801 ttagcattta taaaatatac attatggtgg atactaccaa ctcttatgat agttacagct
     1861 gtaggaatga gtattactat attaacagat acaccagtag caattattgt gcaattaatt
     1921 tggtggcttt acagtataaa ttctacagga ctcaaaggtg attattcaac aatggggcta
     1981 atgataagac ataatagtgt attaaatggg gatattatta tacaaaactt caatcaaatt
     2041 atgattaata gaattgtgat aagtttggga gcattggtgc ttgttttgtt agctatattc
     2101 ttatatgagc aaaaaagaag ggggaatctt gatgtttggg caaagttttc aaaactgttt
     2161 agttctaata aaagaaaact tcaaattaag cactttaact aatttaatat gttcaattat
     2221 attgctatgt atgattcctc taatacaagg agtagctaat ttagacagaa tttcaacagc
     2281 tatatgttta gaaaattatg ttgcaataat agggatagta atgttggtac ctgtattttc
     2341 gctagagcaa tcaaaagaaa ttgatgagat agtatcttca aaagcattat ctcaagttat
     2401 tgtacaatta attaggatac tgatgtcaat tataggtata gtggtattaa tcataggttt
     2461 tgtaaatgtt ttaatatatc ttggatgtaa ttttccagta gttgagtata ttattggaag
     2521 tttcgcatca gctatgttta taggaagttt aggaatgttt ttctcaaatt tatttaataa
     2581 tacaatcata ggttatatga tatctatagg atatttaatt ttaaatatga tgactaaagg
     2641 caagtatgtt ggaaaatttt ttataatgtc tatgagtcaa ggtagttttg atgagaaata
     2701 ttggctgata cttggaagtg ttgtgttgat aattgcatct ctcttaataa aaccagtaaa
     2761 aaggaagatt agataataaa atgagagctt agataaaata aaggtaatgc aaataaaaag
     2821 tacatttatg aaatataaat ctatttttat atacacaaac ctacttacaa tctctttatg
     2881 tatgtagata gatttatata tccgtagtat aaaatatata tgtataccga attttatcaa
     2941 aagctctcaa atttatattt caaagacact tattgctatg acctacacat atgtattttt
     3001 tcattttaat tgttgtatta acaataggac tattgttata aactattgat acctcataac
     3061 aaaaaattct ccatctccta aatgcgtttt ttgtacctta gtctcaacta ttttaaatcc
     3121 ttgagactca taacatttta cagctctcat gttccaggtt cttacattta atacaattgg
     3181 tttagtacta tatttatttc tacattcttg taatcctagg ctaattattt ctttaccaat
     3241 tcccattcca caataattcg gtttcaacca ataccaaaga atacagagct tccttcatct
     3301 aataagttta taaaacctat caattcttta ttgtcattta taaaacttat aaaatttttt
     3361 cttttatctt cttttgctag tgaaaaattc ttctttttaa tttcctccca tggaggtaga
     3421 ttgtatattg aatatttacc ttcatatttc caattagtaa cttcaatagc atgttcttca
     3481 gtaaatttaa ctttatttaa attcatatgt cctcctatta aaatatttaa ggtaattaat
     3541 ggtattttaa agttttagaa aataagtaaa actatttata tttatccata aaatctttaa
     3601 aaattttact aacaattctt gtaccctgta ctttttattg gattcacaga agactataaa
     3661 ctaattttga atcaccttct aattcaaaaa catcacgata tatataattt cttagcttga
     3721 ttaaattctg ttaaatccgt ttcttatagt tgtataatca acatcaatat ctttatgtgt
     3781 attagttaat ttattggttt taggaactta ttattaatat attgtatttg ctccaataat
     3841 ccaagtagta ggtaaattat aggcaaatta tcaaatgtat atctatccat gcttaaactt
     3901 tagagataca ataactacta aattagtgtt ctagtagtta caaaaaagaa tctttaaaaa
     3961 tattaattta acttatattt tttaataaat tttctaaaat ttaataagtt aatttaatta
     4021 tagctctaaa tgatattttc tacagatata attttaaaaa ggtgtgtata agaacaaatt
     4081 cacttaaatt tttaaaatca aataaagttg aatctcttga ctaccttgat tgttttatga
     4141 aattaatata gatgtaaact ttactattaa aaaaatacaa gattttagat aagttaatgc
     4201 taattataaa taataagata agaaatataa tatgacataa gggctaggaa taagataaat
     4261 ataatcaaag aataagatat gagaataact accaagagaa atcattacct taatatgttt
     4321 ataaatgtta gactatgttc ctaaattgaa ttttatatat caagtataat aactttacag
     4381 aatgtggaaa tttttattta aagaatacac ataaatattt ccacactctg attttataat
     4441 aatctaataa aatttatagt gactttataa aatcaataat gatttaataa atatttataa
     4501 aacaactatt tttgcttaga aactttatta ttcatattat cattagtagg cattgctcca
     4561 aaacttagtt tttcatacat tacttgagtt ggagctagcc aaactgtacc actaccagta
     4621 aatgtattta agaaaccttc accatttaaa gcagaaccaa ttaaagattt atctgatttt
     4681 gtaacagaaa aattaacacc agatgttctt gctattgcaa agttaccatc tacctttaat
     4741 tcttcaccat ttttcaattc atactctaca atttcacttt gaggtacaac acattccaga
     4801 acgattacac cagtaccact taattctatt tggaagaagc cttcaccacc aagtaaagca
     4861 gatgagaagt tcttttgtgt aaatgctttt acttctattg tatcagagca acaatagaat
     4921 aatcctttat caacaattat agaatcatta tcaagactca taaataaata atgtctaaaa
     4981 gaaggttcca aataaacttc tccagtacct ttgtatacag gtttcatcat tgattcatta
     5041 gtaagtgctc ctgatattcc ttttttaaaa agacctccaa caccaccaat cttagtttca
     5101 gaagatatat ttcctttata atagtataat gcaccagctt ctgtttttat tgatgaatta
     5161 tttaatttta tcttaatttg tctagctttc aaaccagctt ctctagcaaa atataatccc
     5221 attgccatta atgggctaga agctccctca agtttttcaa attctaatat ctcaaattcg
     5281 cttttgccat ctgatgcatt ttctaaaatt tttacttttt tgcttaaatc catacaaatt
     5341 tctccccact atgataaaat ttatctctaa aatattataa gatataactc tatattacat
     5401 tttttttgaa aaaatcgcta ctttatcatc aaatttttac atatttttaa gaagtttttg
     5461 aaatgtttag atttaagtta agttatttaa ggatgtatag ttatttcaat agacattttg
     5521 agtattattt atcatttgtg ggtattatat tttatgggca tgttaaaatt atttagaaga
     5581 tagaagatag aagatagaag atagaagata gaagatttat aatatgtaat atttttgttt
     5641 tgaaatttat aaattagtat tactggttag agttagttta gtattaagta tattcgaagt
     5701 agttttttag ctattttcat acatttatat tacttaatta tatatagcct aactaactta
     5761 atatatcagt gaaatattga ctaaaatgcc taaatatgtt atcatacaag ttagtcaaat
     5821 aatttggcaa cattaaatat ttagtaaatt tctaacattt atggaacaaa tttctagcaa
     5881 agaaggtgag atttatatgg ctggtaaaaa aatattagca acaaacaaaa gagcaagaca
     5941 tgaatatttt atagaagaaa cttatgaatg tggaattgaa ttaaaaggaa cagaagtaaa
     6001 atcaataaga caaggcaaag ttaacctaag tgatggattt gcatctgtag ataatagcga
     6061 agtattttta aaacaagttc atataagtcc atatgagcaa ggaaatatat tcaatgttga
     6121 ttctttaaga gttagaaaac tattacttca taagcatgaa ataagaaagc ttattggagc
     6181 aactactata aaggggtatt cacttatacc acttagtttg tatctaaaaa acggtaaagt
     6241 taaagtagag attgccttag caaaaggtaa aaaactatat gataaacgtc aagatatggc
     6301 taagaaagat gcacaaagac gtatagaaag agaaatgaca ggtaagtatt aaactagata
     6361 aaactgtatt ttttagaata aaattcttta ttatctagaa cataacattg atttttattc
     6421 ttaaaagtat tatattatat atacattaaa aatttaataa aaatggtgat aaagtttgag
     6481 aaaagtctac tggactataa actactcaag ggggcgtaaa ggtttcgacg tgggtttgga
     6541 acttgaggct gcatgtcgtg ttactctggg tcacgtaaaa actggggaac tttaaaataa
     6601 acgcagacga taatttcgcg atagcagcct agttgctgct cgtccctctt agtcctcctg
     6661 ccgactaaga ctggacgtca ttatgcaggg aactacttta ggggtgtctc gacttgaagt
     6721 agattaattg ggactggcta agcatagagc ctgccacttg gcgctatgtg aggtgagata
     6781 ttagtgaagt tggctaagca tgtagatgca gcaaggaaaa gatttgcgga caggggttcg
     6841 actcccctcg tctccaccat tgaaatccac gaaaacatat tgatagttta gtcaatatgt
     6901 tttttttgtg ccttgaaatg atataattat aatataaact aatgtaaaat ttaactaaaa
     6961 ggagatagta taagtgagta tagataataa ttttaaccat gttgcatttc tgtggaatat
     7021 agcagaaagt ttaagaggta catataaaga agaagactat agaaaagtaa tgttaccact
     7081 aatagtaata agaagatttg attgtctatt agatgattat gatagagaaa taataaaatc
     7141 agtatacgaa gaatacgact tcttaccaga agaagaaaga gatgagctag taatagtaga
     7201 cttaaaagaa aatcacgaca taaacttaca attttacaat gtaagtgatt ttacatggaa
     7261 aaaactatta gatgatagtg aaaatataaa atcaaacttt gaagaatatc taaacggatt
     7321 ctcaaacaat gtaaaagaaa taataggtaa atttaaattt aaagatgaaa taaatcaatt
     7381 agataaaaaa gacaagctat atgcagttct tagcaaaatg tatgaagtag atctacatat
     7441 aaactcagta tctaacaata aaatgggata catatacgaa gaaatgttaa gaagatttac
     7501 agaaaactca gcagcaggag agcaatacac accaagagaa gttataagac tttgtatgga
     7561 aatactattt atgggtaaag aaaacttcct tacagaagaa ggaaaagtaa tatctatagc
     7621 agacttttgt tgtggtactg gaggaatgct ttcaatagct gaagactatg tagaaaaaat
     7681 aaatccaagt gcaatagtaa atgtatatgg acaagaacta cttgatgaat cattcgcaat
     7741 atgtcaggca gatatgctaa tgaaagggca aaatccagat aacataagac ttggaaatac
     7801 tttaacacaa gatagattta acggagaaaa aataagattt ttaatatcaa atccgccttt
     7861 tggtgtaact tggaaagacg aagaaaagaa agtaaaagaa gaagcagact taggttttga
     7921 tggaagattt ggagcaggta ctccaagagt aagtgatggt tcattacttt tcctacaaaa
     7981 tatgataagt aaaatgtatg atgatgaaga aggaagtaga atagctataa tatttaacgg
     8041 aagtccatta tttacaggag atgcaggaag tggagaatca aacattagaa aatggataat
     8101 agaaaatgat ttactagaag gtataatagc actacctact gatatgttct acaatacagg
     8161 aatagctaca tatatttggg tacttactaa caaaaaagaa gctaaaagaa aaggtaagat
     8221 acaacttgta aatgctagtg aatattatca attaatgaga aaaagcttag gaaacaaaag
     8281 aaaagaaata agtcttgaac aaatagaaca aataaaagaa atatatgaaa aatttgaaga
     8341 aagtgaaaat agtaaaatat ttgataacga agattttgga tatagaaaag taacaataga
     8401 aagaccttta aaactaagct ttaaagtaaa cgaagaagct atagaaaatg taaaaaatac
     8461 tactcaattt ataaatcttg cagtttctaa gaaaaaagat atagaagtta aagaaaaaga
     8521 agaagctgaa ggaaaaataa aacaagataa gttaataaaa cttttagaaa gctttgacaa
     8581 tactttagag tatatggaca gggataaatt tataaaagat ttaaaagcta aatcaaaaga
     8641 gtttgatata caactttcag caggacttat aaaggctata gttaatacta ttggtgtaag
     8701 aaatgaagat gcagaagttt gtaaagatag caaaggtaat atagaaagtg atagttcatt
     8761 aaaagatact gaaagtatag gtcttaaaga tgatgtatat gagtattttg aaaaggaagt
     8821 aaagcctcat gttaatgatg cttatataga tgaaagtagt ataaataata taggatatga
     8881 gataccattt actagacatt tttataagta tgaagagtta agaagttttg ctgagattat
     8941 gaaggaagta gaaagtttag aaagtgagat agcactaaag ataaggaagg tgctagggta
     9001 atgggataca gatatagaag tgatgatgag ttaaaggata gtggagttga gtggttaggg
     9061 aagattccta aggattggga agtcagacaa ttaaaaaggg tactatcaga tagaaaagaa
     9121 aataatgaac ctataaaaac aagtaatata ctgtcattga caatagaaaa gggagttatt
     9181 ccatattctg aaaaaggtac tggtggtaat aaagctaaag aagatttaac acaatacaaa
     9241 ttagtatatc caaatgatat tgtattaaat agtatgaatg taattgttgg tgcagtagga
     9301 ctatcaaaat attttgggtg tgcgagtcct gcatattata tgttatataa aataaatgct
     9361 aacgatgata taagatttta taattatatt tttaaatcta aattattcca ggatagttta
     9421 aaaggattag gtaatggaat aatgatgaaa caatcagaaa cttcaggtaa gttaaatacg
     9481 atcagaatga gaattccaat ggaaaaacta agttcagtaa agataccaat tgcttttaac
     9541 ttagatcaag aaaaaatagc aaactttctt gatgaaaaga cttcacagtt tgattcaatt
     9601 atatctaaga aagaaaagtt aatagaaaga ttagaagaag caaagaaaag ccttataagt
     9661 gaggttgtta ctggtaaggt taaggttgtt aagactgatg atgggtatga gcttataaag
     9721 agaagtagtg aagagatgaa ggatagtgga gttgagtggt taggtgagat acctaaggaa
     9781 tgggatataa aaagacttag atttttagga aaactacaaa acggtataag taaaagtagt
     9841 gattcattcg gttatggtta tccatttgtt agttatagta atgtatatag aaatatagaa
     9901 ttaccacata tagtagaagg tctagtaaat tcaactgaag aagaacgtaa aatttattca
     9961 gtagaagaag gagatgtatt ctttacaaga acttcagaaa cagtagaaga aattggtttt
    10021 gcttctacgt gtatgaaaac tattgataat tctacttttg caggattttt aataaggttt
    10081 agaccgaatg ataaaagact atacaaagga ttttctaaat attactttag atgtgattta
    10141 aatagaaaat attttgtaaa agagatgaat ttagtaacta gagcatcttt atctcaaaat
    10201 cttttaaata atctttctgt tgtattgcct aagtatgaag aacaagttga gatatataat
    10261 gcacttgaat taaaagttag ctacattaat ttatcgatta ataagttaaa gtaccaaata
    10321 gaaaaactaa aagaagctaa acaaagttta ataagtgaag cagtaacagg aaaaatagag
    10381 atactagatt aacttctagt atcttaatat agatatagat tatacataca aagttaaata
    10441 aaagggagaa ttaatggata aaaatatatt tcaaattaat ataaatacag atgtactgat
    10501 aagattaagg aatcaaataa atgaagaata ttatatatct tatagaaaag aattttatga
    10561 taaaaataat aaaaaacatc gcgcttggga taaaatatgt gcaataatgg ataggcttga
    10621 cgatactgta gattatttaa ataaactcaa attaaataca ggtaaatata gacgaagtgc
    10681 atttgacttc tttgaattta tgaatcaggc ttccgtagta atggattgta taacacatct
    10741 tgcaaaaata tttgaagtac catatgaaga agttgaaact tcaactgaaa tttttaatga
    10801 gcttggaaaa gagggtaaag gtacagataa aaaatacttt gaatatctac gttcattgtg
    10861 ttcagtccat ccaatggaaa ctagtagaca caaaatatac caagaaaata gttttgaatg
    10921 tagtccttat gtagtttgga atgataaaag tatatggact aatgatgcta gcgatttata
    10981 tgcagtggta tacacaagta aagataatga tagtttcaaa agaattcata tatatatgaa
    11041 tcaaatattt gagtatgtaa aaagaagagt aaattttatt gaaaatataa tagaacatat
    11101 agaaaagtat caacaagaaa taattgaaat ttttaggaat actccaataa agaaagaaga
    11161 agattttgaa agttatatag attatttaag aaatctaaaa aaagagatag aaataagata
    11221 tggtaatgat tcttttcatg aattaaacta ccttatagaa ttatttgatt tgccattatc
    11281 aaatcctgat aatgaagaga agatgaactt atataaaaat gctttaaaat atgctatcaa
    11341 atttgagcat aatagtattc aaaatatgac aaatgaaggt tataagaata atggaatatt
    11401 atatccacaa gtgaatataa caactacatt actagaagag ctaatttcat taaatagtgg
    11461 tagtgaggag agacgtaagt acagatatgc aatagaaaaa acatcatatc taagctatga
    11521 tagttgttgg agtgatagag aatgggcata tgatcaaata gatgatatga tgcctttttt
    11581 agaaagatac gtaacatttg ataaagctca aagtgatttt gagcattatg tattggtaaa
    11641 actagcactt tatttagagt gcttagaaaa tgaatgttta ataaataaga acgttcctaa
    11701 tgataaaaag tttcgtatta aataattata gctaataaaa tagggagagg gaggatatta
    11761 tgttaccaaa agaaaaacac ctagaagaat ctattgaaaa tcatttagtt tcaattggat
    11821 atgaacaagg tcattcacaa gaatttgacc ttgaaaattg cttatttgta gatgatttat
    11881 ttagattctt agaaaatact caaaaagaat tactagatga gtttaaatac aacaggggaa
    11941 gtaattacaa aaaagctttt atagatttat taaattcaaa catcaaaaga agaggtctta
    12001 taagtgtact tagaaatggt gtagaagata taatgatgaa cggaaaattt caattattct
    12061 acaacaaacc aaatctaact actaataaaa cagcgtatga aaattataaa caaaatatat
    12121 tcaaaataac aagacaatta aaatatagct caaagcacaa caatacttta gatatagtat
    12181 tatctttaaa tggatttccc gttatagtaa tggaacttaa aaatcagttt actaatcaaa
    12241 atgtgtataa tgctataaag caattcaaaa aagatagaaa cccaaaagaa actttatttg
    12301 gatttaatca aagagtgtta gtatattttg cagtagatac tgatgaagtt tatatgacaa
    12361 cagagctaaa aggagataaa acattcttct taccgtttaa taaaggtaac aatagaggta
    12421 agggaaatcc tgtagtagaa ggaaaagaaa aaacttctta tctttgggaa gaaatactta
    12481 ctaaagatag tttacttgat attataaaaa gattttactt tattcaagaa gatgataaag
    12541 gtaatcaaag agcaatattt ccaagatttc atcaattaga tgcagtaagg aagatagtag
    12601 aagatttaaa gataaataaa gtaggtaaaa attatcttat ccaacatagt gctggtagtg
    12661 gtaagactaa cactatagca tggacttcac ataggttatc aagtcttcat gatgaagaaa
    12721 ataatgctat atttgactct ataattgtag ttacagacag aaaggtactt gataaacaat
    12781 tacaaaatgc tatatatcaa ttagagcaca aaaacggact tgttgttaag atagatgaag
    12841 ataaaaattc atcagactta gcagatgcta ttgtaaatag agcaaagatt attataacta
    12901 ctattcaaaa attccagtat gcactaccta agatagaaca acttgataaa aggcgttatg
    12961 cagtaattat agatgaagca cattcttcaa catctggtga aaatatgaat gcattaaaag
    13021 aaactttagc aggaaagact ttagaagaag ctaaggtaat tgatgcggaa aatgaaaaga
    13081 atgaaaagtc tagtatagat aagatgaatg agcttataga gaaaagaaca aatttaggaa
    13141 atataagttt ctttgctttt acagctactc ctaagaataa gactatgcaa gtatttggga
    13201 ggataggtga agatggacta cctcatgaat ttcatttata ttctatgaaa caagcgatag
    13261 aggaaggatt tatattagat gtactaaaaa actttatgcc tataagtgtt tattacaaag
    13321 taggaaagaa aattattgat aaccctgagt ttgataaggg agaggctaag agggctataa
    13381 ataagtttgt tagtttaaat gagcacaata taaggcaaaa ggttgaaact atagtagatg
    13441 attttgtaga taataggtct atgtggttag aaggtaaagc taaaggtatg atagttactg
    13501 caagtagatt acatgctgtt agatataaac tagctataga ccaatatata aaagaaaaag
    13561 gatatgatat gaaagcactt gttgcttttt ctggtactgt aaaagatggt gatgatgagt
    13621 atacagaggt aggtatgaat aaggaagtag caccagatat tactgattca aatttaccta
    13681 atatatttga taaaaatgaa tttaagctat taatagttgc agaaaagtat caaactggat
    13741 ttgaccaacc aaaactttgt gctatgtatg tggataaaaa actagatggt gttaaaactg
    13801 ttcagacttt atcaaggctt aatagaactt atcctaataa acaaacattt atattagatt
    13861 tccaaaatag tgtggaagac atacaagatg catataagcc atattttgaa atgactaata
    13921 ttgataaggt aacagatcca aatgtagtaa atgacctttg gtatcagtta catgaatatg
    13981 cagtatatac tgatgaggaa gtaaatgatt ttacagtatt attctataaa gagaaaagaa
    14041 cttcttctca agatgctaag atgaataatt taattgataa ggcagttgaa aggtattgtt
    14101 atttagaaga agatgatgaa aaaaaatctg atgagtttaa gaaaaaatgt caaaagtata
    14161 ttacttttta taatttttta attcagattt atcctataaa gaacttaaat cttttaagat
    14221 tgcaagttta tttagtagca cttttaaaga agttacctaa aaagagtaaa caaagaatag
    14281 accttgatga tatgttaagc cttgattatt ataaattgca aaagcttgga ttagatgata
    14341 aaaaaggaac ggatatatcc ttatataatg gagaaggtga gttagttggt atatctgaaa
    14401 ctgcgacttc tcgtgtaagt gaagctgatg aagagtattt agaggatata attaaaaaaa
    14461 taaatgatgt ttttggtgta ggacttacgg aagatgatag aattatgata aatacttatg
    14521 aagagatgtt taagaatgac aaggatatca tggatatagc taaagctaat agttatgaag
    14581 atttagttag cacttttggt aagaagtatt ttaagagagg tatagttaaa accaaaaata
    14641 gaaatgatag attagttaag gagatattaa ctaataataa tttacaaaat tatatgattc
    14701 attatttagc tgaaaagata tatgaagagg caaatagata agatacctat agagagctaa
    14761 ttaactctcc ataggtactt tattatgagc tattgtatat tattcatctt ctaaaggtgt
    14821 agcaattcct tttaattcta aaaactttaa gtctaaatca agaataagct ctatagtatc
    14881 tctatctata gaaacacctt cttttttaca ctcagtaagt ataaaatcaa cttcttcttc
    14941 aaactctata aatggtttat cgttattcat atttttgctc ctttgattaa atataatgta
    15001 tttactttaa attatatcaa agaagagaaa aaaataacat tatttgtaaa aaactatata
    15061 tatataatat atagttttac catatataga taaactgttt ttaattaaat tataaatata
    15121 tattatatta atgaatctat attaaataga tagttgagta agtagtaata ccaaaaatat
    15181 taaaaagaga tgttggtaga aatacgaaca tctctttttt agtgcaaaaa attaaaagga
    15241 ggaagttaat atgattaaat tatggaagaa agaagattta aatttattat tagaatatcc
    15301 aaaggaagta gttgaaaatg ttgataacgt cattaatatt cttgatgaaa actatggatg
    15361 taacagaaaa ttaacagatg atggtggata tgtgtgtata attgaggata ttaaagaagt
    15421 agaaaactta aaatcaaata tattaaaggg gttagtagaa gagtttagtg atgtaatata
    15481 tgaagatgaa gttaatacat ataattcaac actatacttg ttatctagtg attatagtgt
    15541 tactgtaatt tctaaaaatg aagaaactga gtacttactt aaataagcat atacattgat
    15601 aaggtgtata tgcttatttt aattttaata aataaaggag aaaagcagaa tgaataaaaa
    15661 gagaactcct gccaagagag ttgatatagt tttacttaaa ttagtaaaag aacgtagtgt
    15721 tctatatgaa actagaaaaa taagtaatct ttatgatgct tatagattag caaagaattt
    15781 tttataaata gtgctagaga aaagtttgta gtggtatgtt tagatacaaa gaattggcca
    15841 gtagcataga ggttgtaagt ataggcactg taaatttatc tatggtatat ccaagagaaa
    15901 tatttaaagt agctatatta accaattcat ctgaaatgat atgctttcac aatcacccaa
    15961 tgggtaatac tgactttagc aaggaagata gttataacta atatgctaca gaagcgtgga
    16021 gaaatattat gcattgaatt agtagataca tatagttatt gtagatgagg ataaatactt
    16081 tagctttaaa gaaaactgta ggatataaga gtcttagctt aaataaatta ggctaaggct
    16141 ttttctatgt tccaaaacaa ttaaaaataa atcaaattta ggttaagccc ggaaagccct
    16201 tgaaaaaaat aatacatata aatttaaaac taaataggag ttgtaacatg tttaaaaaag
    16261 aaaataggta tatgacaaaa gagatagctg aaaatctacc aattgaaata gctatactac
    16321 tatggaattt aatagatgac ttaactacag aaaaagatta tctacaacta tttgaaataa
    16381 atcctatagg attaggagta gttgagatag ttcataagca agaagtacct gaatatgaag
    16441 ctaggatata tatacagaat gataaaatta aagataaatt aaaaatatat gttatagata
    16501 atgttgaata tagaacaatg atgttttcaa atgaatatta gttaatgatt aaaggagaga
    16561 gagtaatatg ataaataata aatctgaaat aattaataag ttatttttca atgaattaaa
    16621 agagttaata gataaataca acaatataga tgataaaact gtagatgtaa tagaaaagat
    16681 atttacatgt atagaagatg aagaaataaa gaattaccta ataagagata attgtaagct
    16741 acaagagcta gtaaatacat acaataaact tgaagattta aacatagatg aagctatatt
    16801 ctttgcttgg tacaacttaa ctataaatac aatatctata gataaagcaa gtgagtacta
    16861 cgatgattta actacaagta actatataga agtagaaaat catataatat atacaaatga
    16921 aagagattta aggaagtatg ctgaagatga attagaaact atgttaagca tggaacatca
    16981 tatagataga ttactacata aagacatgtt aatagatatg tggttaaaca atacttcaaa
    17041 agaagaagta atagaagaaa tattaatgag tgatgatata gaagatatat tgaatttatc
    17101 tccagaatat gcatttacat tagctaatgg aatagaatat agatactcag aaaaagaaga
    17161 ataaaataag tatatgtact gaaaaatacg ggctttaagg gcttatacat taaagtacat
    17221 atttgaaaat accatagatt ttacaagaga aaatcagaat gaaacttttt caaatactag
    17281 ttattattaa ttagtgctag aaaaggaggt ggagtgatga ctaacaacaa taataattgt
    17341 gattataagg gcatatatgc agatatggtt gaggttttgg gtgaagaaat agtcattaaa
    17401 ttacataagt attatcgtgg acaacaaata acatttccaa tgaaactata ttctattgaa
    17461 tatgtggaac gatatatagt gaagaattat agaacaaaaa caataaaaga aatgtgtaga
    17521 gagttaggat atacagaggg atggataaag caattaatta ataaaaatag attaaattca
    17581 aagtaattag agaaggagat tgacagtaga tatgatatta acagtattag caatacttat
    17641 ggggacaggt atattttttc tgattaattc aatgctagat ataacgtatt ttggatgtgg
    17701 cccaatagga tttttatggt ttggatgttt tattgtgtca tatgcaatat taacatcatt
    17761 aggtggtata gttttaggat tgttaaagtg gatagtaata ggattgatta tactatttgt
    17821 aataggatta atagcgaata agataaatga ttaaattact gtagattatt ttgataaaat
    17881 aattatttaa tatattgagg cattacatga tagaagaata aatataaatg acttaaaatc
    17941 tttaacttaa ctaaacaaaa aatatattat ttattacaaa aaatgacaaa aaaattaaat
    18001 attatattgt attatgacaa tataaaacat tggagtttat aaattaggag gaatatttta
    18061 tgcaagattt tgattttata agtgagacaa taaagaaatt tcaatccgat ttagaaaaca
    18121 tggataaggt aaatatactt gttgtaggta aaacaggagt aggtaaaagt acattaataa
    18181 ataatatatt tagagaagaa ttagcagaaa ctggaattgg tagacctgta acacaacact
    18241 tgaaaaaaat aagcaaagaa ggattaccaa taaatttata cgatacaaag ggattagagt
    18301 tagaagaaga tgtgcaagag actataaaaa aagagatatt agatgaaata gaaaattgta
    18361 atagaaattc attagaaaga aatgataaaa gtgagttaat gcatgtatgt tggtattgta
    18421 taaatacatc agtagctaga tgtgaagaaa ctgatataaa atggataaat gagttaagtg
    18481 aaaagatacc agtaatagtt gtattgacac aaggattccc aagaaaaaaa gcaagagaat
    18541 taaaatctag tattgatgat ttaaatttaa actgtaagaa tgtaattcca gttttggcag
    18601 agcaactagt agaagaagag gatgagatag ttataaagtc atatggttta gataaattag
    18661 tagaagttac atatcaagta ataccaaaag aggtcaagaa agcttttgtt aatgtacaaa
    18721 aggtagatat aaaaaaaaag gttgaagagt cgagaaaatg ggttttagga tatgtaggag
    18781 gatcaggagc aataggattt tcaccaatac cattttcaga tgctccatta ttagcaaccg
    18841 cacaagttgc tatgatatct catataacag taatatttgg gttacaagtt gataaagctt
    18901 tactaacggc aattgtaagt tctataggag gggttacatc agctacttta ctaggaaaaa
    18961 cattggtatc gaatatactt aagtttatac caggagctgg aactatagca ggtggagcga
    19021 taagtggttc tgtagcggca ttaacaacta cagcattagg aatggcatat ataagtgtat
    19081 tagaatatat actaaatgag aatatgaaag gtaatgaggt taataatact gaaatagctg
    19141 aaaaaatgaa agatgcatac aaagatcaat taggaatgtt atctaagaaa taattaattc
    19201 aagataaagt ataagattaa ttatagggaa aaagtaaaat ttaaaggtat atttggtaaa
    19261 acataaacaa aaatgataat ggcgtcaata ttatttgttg tcatatgtag tagcttagta
    19321 tatatattat tgagtgatag gtttaatcat aagttaattt acttagagaa agatatatta
    19381 gatttaagaa ataaaaattt gtaactagct aataaaggat cagtatagaa acagataaac
    19441 aagaggataa tgtagatatt aaatctaaaa acactaataa tgaagaatat aaaacttcaa
    19501 aactatttag gcactagata gagtatttgc tataatgaat aagctaatag agaaattaaa
    19561 acgtttatag taagataact aattcaaata catttagtgg acttcaagga acatttgata
    19621 cactatcaaa ctatggtagc taattgatag accaatcatc taaattgaat ttatcaaatg
    19681 ttggatggtt agaaatatct gatataatta caagtatagg aaaggactat tagattctga
    19741 aaatatgtca tttgaagcat taaatataat gggaaaaata ggaaaattta taaattatat
    19801 tgaaattaat tatattaact aattaaatat tgatacataa tgccttgcta cagttaaatg
    19861 tggcaaggca ttatttttgt aaagaaagga agaattaaca tggcgaagca aagtaaagag
    19921 gaactatttg aaaaagaaac taaatattgc aagataataa gaagtgtaac agtagaagat
    19981 ggagatgaaa gatttgcaat agagaaaata tatattaagt cattacaaag atacgaggtt
    20041 agaatatgcc tgtatcgtga ctgccgagat agaattaata aacttattcc aaggcctgta
    20101 gatttaacta tggataagtt tgtagcatta atactggtag gattaaaggc tggtgtacta
    20161 gatgatgatt tcaagcaaga actaattaaa ggtttagctt aggaggtaga atatgacaat
    20221 agaagagttt actagtggag taatgtttgg gatttcaatt tttagtgcag tattaaagca
    20281 agtattagaa aataaaaaat agtatacagg aggtatgagt atgattggat ttataatagg
    20341 aagtataata ggaattggac tatgtattag tatagagata ctgatatcga aaaatgccat
    20401 aatatactaa gttatattta aattattaat agattcatat ataatttatt taagccctta
    20461 aagcccagat aagttatatt aaagtaaagt ttgtatttat gtaaattaaa taatatatat
    20521 tattataaat ttgaaaggac tttataaata tgaaaggcaa tataaacaaa aaagatatag
    20581 atttaagtaa aataacattt gataagtttt tagaagatga aggattacaa aatagagaga
    20641 gagattactt atatgtagat gattatgaca atactttaga tactcaagaa tttaaattac
    20701 atataattga agagaatact gataacacat atatagataa agataaatac tggtatttag
    20761 atttagatga tagtttattt gaatacgaag aagatgaaga tactattgct aaaacattat
    20821 atagtctaat agatattaga attaaatttt tgaaacatgt tgagtataga aaatatataa
    20881 atctaggagt aatagacgaa gaatattttg atgagattaa atcatttttg aaattttata
    20941 tagtagcaaa aacaaagaaa aatgagctag gtaattcaaa tttaaagcag atggctatag
    21001 atatttttga taaagaaagg tttgaagacg acatatcaga tgatgatatg gaaaatataa
    21061 gtgaatggat aggagaagat caaaacttta aaatgtttta tgataaagtt tgtagggatc
    21121 tctcaaattc tacacaggat aaagaaatat taaaattagc aggaatcagg aataataaag
    21181 taaaacatta caaaggaaga aaaattagta gaaaatgtaa attagaactt aaatcattga
    21241 ctaaaatgtg ggagtatgaa actaaactga ctcatgatgc aaataaggca cataagaaaa
    21301 taaaatctaa tatgcttgaa aaaatgacag ataagaatta taaaaatata tatgaatatt
    21361 taaataatga gattataaat agtaatgaag aatataaaaa tatttatttt tatagcttag
    21421 aattaaagtt agcgaatgaa ttaagaaagt gtactcttaa aaacttaaat aaaattaaag
    21481 acatagaaaa tcaagtaaaa tttatttctt atactattgc ttatatacac atagttccag
    21541 ttttaacgat aagagagaaa ctaagcgata agttatttaa tatattgtca actaatgaag
    21601 gtaaggatat agaaaaattt actaaagaag ttagtcttat aatgagaatt ataaatatag
    21661 aatgtttgga gttattaaat atagttagta agaacaacta ttataaaaat tttagtgaaa
    21721 aggaattaga ggagtttaaa tctatttata atataaataa tggaagaaag tcatttgaaa
    21781 ataaatataa aataaaagta gattataata tagatgatgt aagaaagtat ggagaggtta
    21841 taaaagcaat aaatatagaa agtaagaaga aaattgtaga tagaattaag aagaagagaa
    21901 aatctaatta gattttctct attttttttg aaaaaaataa aaaatatttg gtgaaaacgt
    21961 ttatctttag gtgatatgag tagtcattat ttattatata atcatatttg taggaacgag
    22021 ctaattaata aaatctaaga acaatagctt aatgatgaaa aagtacggcc tttcgggctt
    22081 tgacaacagg aggtatatta atgacaaact ttaaaagtgt aaaggtagaa ttaattctac
    22141 ttattgaatg tgaagaagga aatcgtaatg aattagaagg tatgattgat gaaggtgtat
    22201 taaatgaaaa agaatatagt ttaactatat taggtagtac agagtatgaa gataacgcaa
    22261 gggctattta catacttatg aatacaggag gatcatacga aaaaaactta caacgattaa
    22321 gtagattaca cttgaaaatt gaaaacttac ttaaagatac aaatgttaaa tatagaggta
    22381 tatctttagt accgaatatt gttaaatggg ataaatagga ggaatacaaa tgagcaaggc
    22441 aataaacaga gaagaattaa ttaaattata tgaggaaata ggattaaatg ttttagataa
    22501 taacaccgtt atgaattcat ctaataaaaa gatatgtaat tttttagtaa atataataga
    22561 acaaagggtt atagatggaa aaatgtattt atgtataaat gctatgggga ttaatggaga
    22621 gctattatca gaggtaatat tagattcgaa taccataaat agaactacat gggtgattga
    22681 aaattggggt tttaaatatt ctatagataa aaaatatatt aatgacttta ttgaattgat
    22741 acaacactta tgtatgaata taaaaactaa gtatatatat gaccatacag gatggatata
    22801 tcaagacaat aagtggatat atctacatgg aggaggagtt ataggaggtt cagatgttca
    22861 agttgagtta gatgaatcaa tagataacta tatactacca gataaaatta gtgacataaa
    22921 taaagcatgt gaaatgagtt taaagctagt agacttaata gaagatgata aaggtattat
    22981 attctcttca ttagtttacc tatctccact tattgaaatt atcagtagaa aaattaaacc
    23041 accggaaaat atagtatgga catatggaaa aacaggatca agaaaaacag cagtatcaaa
    23101 agttgtatta agtcattttg gtgattttaa taaaaaaatt ccagctacat ttaatgatac
    23161 gattacagct attgaattaa aagctaataa gttaaaggat agcttatact tatgtgatga
    23221 ctttgcacct aaacaagact ttagggataa aaaaattcaa gactcaaagg cagaatccat
    23281 tataagaatg tatggagata gagtagggaa aggacgctca agtaataagt tagatataaa
    23341 ggatgctaag agacctagag gaatgatatt aataacaggt gaagatgtga tatgtggaga
    23401 atcatctaat gctagattat tatcaataga attaaataga agttcagtag atttaaatat
    23461 actaactgaa ttacagaata atagtcattt gcttggagaa gcaatgagag gatatataga
    23521 atggttatta tctgaaatgg gaaatattga tgaattatct aatatattat tatataactt
    23581 taaatcttac agggatgaaa ttagagaaca atataaagat gatatacatg gaagaactat
    23641 tgagtctagt gcatggatat tagtaggttt tagttgtatg ttaaattata ttagagataa
    23701 aggtgttata gataagtatg aagatgatga gtacatggat agagcgatta aagttgtaga
    23761 aagattaata gaagagcaga taaaattaat atcgagaaac tcacctatag atatattttt
    23821 aaatacatta aaggaatcaa taaattcaaa gtcaataaga atagcaacat taaatgacca
    23881 gaaccaagtt atagaagata aattagaata tatatgtgga tataaggata aggaatatta
    23941 ttacttttac acagataaag tatattcttt tatagaattt gaaaataaaa aaagaggtat
    24001 acatttggga ataagtcaaa gacaactagt gaaacagtta agagatagtg gaattgtgaa
    24061 agttgattct aacaatgatt ctcctaaaaa aactattcat acaaaagatg ctagcgattc
    24121 aacaggatat acaacaataa gaccaagaat gcttcagata gaaagaagta taattgagaa
    24181 ctttcaaata taacttataa tcaagagtgc ttatgtactc ttgattatat tctatgataa
    24241 atggaggata taaatatgac agaaacttat aaaatcagca taggaagaaa agatttatat
    24301 tctaaagact ataaggtagt tgaaagaact gactatgaaa agagacacac agttaatata
    24361 agtagaagct tagtagacat actttctata cttgtaaaag aagatagata gattaaaata
    24421 tggttacaca cttagtgtta gtgtgtagcc tttaatatag attaaaatta gtatatttaa
    24481 actttggagg aaataatatg acaggaaaga aagcagtagt atatgcacgc tttagttcag
    24541 ataatcaaag ggacgaatca atagatgctc aattaagagc aataaatgaa tatgcagata
    24601 agaataatat aaaaatagtt aatcaattta tagacagagc aaaatcagca acatcagata
    24661 aaaggccaga gtttcaaaat atgattaaat tctgtgaagc agatacaaca ggaatatcta
    24721 tggtaatagt tcataagcta gatagatttt ctagagataa gtatgattca gctatgtaca
    24781 aacagaaatt aaaagtaaaa ggaataagag ttgtaagtgt attagagaac ttagataatt
    24841 cgcctgaatc cctaatatta gaatcagtta tagagggaat ggcacaatat tacagtgcta
    24901 atttagcgag ggaagttgct aaaggtcaga aagaaaatgc ccttaaagcc cttcataatg
    24961 gaggcgatgc accattaggt tatgatgtag cacatgataa aacatataca gttaatgaag
    25021 aagaagctca agcagtaaag attatatttg atagatatat taaaggatat tcatatagta
    25081 agataataga tgaactaaat atcttaggat ataagactaa aagaggtaat aaatttggta
    25141 agaatagctt acatggaata ttaaataatg agaaatatac aggagtatat gtatttaata
    25201 agactcagag aaaaggtgta gatggaaaaa gaaatggaca taagcaaaag agtgaagagg
    25261 aaataataaa aatagaaggt ggtatgccac aaataataga caaaggagta tttaaacaag
    25321 cacaagatat gattcaaaaa agaaagaaaa ctccaggtgc acataaagct actactacat
    25381 atctattaac aggactaatt aaatgtggtg aatgtggaca tgcatttcag gggaataaga
    25441 gaaaagattc ttatggaaat gaatatgttt catatagatg tggatgtaga aagcaaaaga
    25501 gagaatgtaa taatagagag ataaaaagag actatttaga agagtttata ttacaagaac
    25561 ttgaaaagaa catattaaat gatgaagcta taccgatttt aagtaaagca ttgaatgaga
    25621 agctgaatga taagaatgaa agtaatgcag agctacttaa aaatctagag cagaaactag
    25681 ataaggtaaa taaagagata agtaatatac taaatgctat aatgaatggt atagtaaata
    25741 gcatgttaaa agataagctt gatgagctag aacaagtaaa gttcaactta gatttaaaaa
    25801 tgaatgaact aaagatagaa aataaagttg tagatggtgt aggtgtaaca gaagatcaaa
    25861 taagaggtat gttttcaaga tttaaggaat ttgtactaga gagaaatata cctgaatgta
    25921 agaagtttat aggagactat ataaaggaag taatcgtata taaagaccac attgaagtca
    25981 tattcaatgt ggtcttttgt tttgttgaca atgatataac tcatgattta catattatca
    26041 cagaaagggg taaaattaca tagtaaatat atattttata aaagtaaata tcagatatta
    26101 tttagataaa aattattttt gaaaatatta gttttaaaaa atatatttat ataattataa
    26161 aataaaatgg tataataaaa ctttaaatat gataaagagg tgagactatt ggcagatata
    26221 tttacagtac taaattatca aggtagtaaa aagagattat tagattttat atatgaaaat
    26281 acacaagaat atattgattc tgataaagct tttttagata tatgctcagg aacgagtgca
    26341 gtagcttata atatgaaaag acactttacg gtttatacaa atgatagtga aaattatgca
    26401 tatcagatat ctaattcaat tgttaagaat aatgaaagat ataactttag tcaatcagat
    26461 gaaatgatca taagagaaaa atataatatt aatttacaaa gattaaataa tatttttaac
    26521 gatatggtaa atcaggaaga tatgttatta gaacaagaag atgcagacgg tttaatagag
    26581 ctatattcaa attgcccatg tatatggaaa aataatgttg atattgaaat agaaggcaat
    26641 acaatacaga gtatatatga tttaagaaaa tgtaaacgag acataccgaa tgtgttattc
    26701 acattgtatt attcaagtag ttacttcggc ataaagcagt ctatggagat agattctatt
    26761 agatatgcta ttgaatttat agaaagtgaa ataacaaaga gcattctttt tacaagttta
    26821 tttttcgcaa tgaaagagtg tgtttttgct aaagatggtc acatggcaca gccattaaat
    26881 atggaaacag gcaagaaaag aatgttaaga ttaaaagcaa gaagtatata tgacatattt
    26941 atagataaat taaaggaatt taatactgag gagtttgtat tatcacaaaa ggagaataag
    27001 tgcttcaata aagactttag aacattatta gaaacagaag aaagtataaa agatgaagtt
    27061 ggttttatat atatagaccc tccgtataca gatatgcaat actcaagata ttatcatatt
    27121 cttaatacag ttgttttgta tgattaccca gaaatatcat tgagtagagg aactatatca
    27181 aaagggatat atagagaagg tagatatcaa tcacctctta gtcaaagaaa acatgcatta
    27241 aatgagattg atttcttatt tagtttctgt aaggaaaata aaataaatgt agcattaagt
    27301 tatgcatatc caatagatac agaaaaacaa gcaactaata gatatacggc tagtattgat
    27361 gatttgataa atgtagccaa aaaacatttt ggagataatg ttaaggtagt acatgaagaa
    27421 tatagtcatg caaataatag aaatagtgat aaaaagaatg tacttgaata tttaataatg
    27481 ggtatacaca ataaggagta aatatggata aaattaataa attaaaagag aggatagcta
    27541 atatagaagc gacgaataaa aatgatatat attcttctaa cttatattgg tcacaaaaac
    27601 cattcaatat atgtgatgaa attattgaac atttaagtga agatggagat ataatatttg
    27661 atccgtttat gggatctggg gttacagtta tagaggcttt gaaaaaagag tataaaagaa
    27721 atgctattgg gtgtgatata aatgatgcac caatatttat agtaaaaaca ttattagaaa
    27781 aatataatgt gcctaaaata gagaaagata ttaaagagct aaataataaa ttaagtaaat
    27841 tatcaactta ctattcaaca aaatgtcgtg aatgtggaga agtagttact atatcgaaaa
    27901 ctatattcga taaggagaat aggaatgcaa agtgtgagct aaagtctata cattataaat
    27961 gtaaggaatg taaaaatgac tttaaaggtg aaccaaatga aactgaaata tctaaattct
    28021 ttattgatga agaattaaag aatatagatg attttcaatt catagccaat tcaaggcttg
    28081 cagttggcga aggtgataca gtaagaacta ttttttcaaa tagaaattta atagtattag
    28141 ataaaatatt aggacatata gatgaatata aaaatagtga atcttatgag cctatgaagt
    28201 atattttatt atctatttta catttaagta agattacaga tacacattct aattctcagt
    28261 ggcctttatg gattcctaaa aaagactgtg ttgaaaaaaa tgtagtagaa ttattcataa
    28321 agaatagtaa gaaaaccatt aaggcattaa aactagcatc taaatattta tgtgaaaata
    28381 gagaaaatgt agaactaatc aaaaatctag atagagggaa atttaaattg ataaaagatg
    28441 gagttcaaaa tatagaagat gatgttatac ctaatgaatt tgtggacttg ataataacag
    28501 atccaccata tatgggacaa gttttatatt cagagtatat gcagttatat aaacctttta
    28561 tggatttgga attcgaatta gaaaatgaaa tagttatatc aagtgcccca gctagagata
    28621 aagggaaagt attatatttt gatatgatga attctgcatt tgaaaatata tctagagtat
    28681 taaaggtagg taaatatatg tgtatgtact tccatgatag taatctagat gtatgggata
    28741 atataataga tataatgacc aataataatt tgaaatacat gggacaaatt catgtaagta
    28801 agaataaaaa cactcttaaa aacatactta gtcctaagaa gtcgttaaat ggagattgta
    28861 taattttctt taagaaagat ttaaatataa actatgatat aaatgaagta gataatatag
    28921 aagataagat aaataatatt gcacaagcta ttatagatat aaaaggatac gcatcaactc
    28981 cagagttata tgataatgga gcactagagt atataatatc aaacggaaaa ctaaaagaga
    29041 tttctaaaaa gtataaggat ttaacaagta tatttgagca aagatttaat tgggataagg
    29101 aaagaggggt atggactgta taataaataa aaagcatcta tagataatta tagatgcttt
    29161 ttatttatat tttatagtaa actaaatatt taataatttc taatttttat acaatatgtt
    29221 aaaggattgg ctatccaaag atattattta atataatttt ttagcattaa ctctagttaa
    29281 atcactttta gataatgaaa cctgtaatct tctgatagga gaaccctttt ctaaacatct
    29341 attgatcttt tcctgtaact tcttacgaag aagaggaact acatctgctg gttcagttga
    29401 gtagatatgt tcaacttcta tattttcttt atcaacaact gctaatatta tagctttatc
    29461 attataatat ttatttagta cattatcaga tatatcttga aagttccaag catgattttt
    29521 agaaacttta tattcataag gattaccttc actatcatag gcatcatgag caccttctcg
    29581 tccaccttgc tctgggttta cttgatggtt taattctaat gcaactatta attcccaaaa
    29641 cttattactt gtaagtaaat ttttaactcc tgttaattct tcaagttcac ttgaagcttt
    29701 ataaatagca cttagatatt tatcataaac accattttga gctgatggga ttatcttact
    29761 tgcatttaat ctagactcta gttgattagg gctgacattt atcatttttc tggaattttg
    29821 tatactttga gtatacttta gtaaatattc acacattata tctccaggta tagagtaata
    29881 ccaatcaagc tttccagggt aaggaaaatc aacatcattt atatgagcaa atataactgc
    29941 cttagctttc tttaattttg ctatacttgt atccgaaaaa tcattaaacg tccaagaatg
    30001 gttagagcta cttttcttga aatgtttata ttcaaactca tttccgaatt catcttttgc
    30061 atctctagaa ccactatgtc caggtattag tatgtgatta agtgaattag cagtcataac
    30121 ttcatatatt ttgctattag aaagtatatc atttacttta tattctttaa aaataccatc
    30181 ttgtatagcc tttagttcat ttattttctg tgttattaaa acatttgtta tattatctct
    30241 tatcatatta tcatagctcc ttaataaatt agtattttta gataagtcat ttttaattag
    30301 atttatcaca taactattga tgctatcatt tttaaatgct actaaatcca ataaatcttt
    30361 atgaaaatca tccttgagtc ttatagttag ttttttcaag ctatcacctc ggatattaat
    30421 tagatgtgcc gtcgagataa gtataattaa gcaggtttat aaagtcaagg attaaaaaaa
    30481 ttaaattata gatatataaa agtatatata gcaatataga taaatagcta aactattaat
    30541 cgtgggtatt attcttgcga ttcgtctcca ccaattttga aaaaagaatg atgaaatact
    30601 tggaaatact agtctttgtt gactagtatt ttttattttg gagaagaaat ccaccaaccg
    30661 taccccaacc acagaaaatg aggttttttt gggggtatat tggggtgcat ttaggctgta
    30721 taaaaagttt ttatttgttt attattttat ttgtttatta ttttatttgt ttattatgat
    30781 aataggtaac atagaatttt aatatctact ttatgatata atatttttat aaatgtaaga
    30841 cagtttaagt tgttaattag taaaaatata tattatataa gcttgatagg agttgaggtt
    30901 tgtaatggat gaaagaaaac tagaattttc tattttttgc attgaagctt tagcagaaaa
    30961 attgaatata gattcagaag gagtttataa acttcttaaa catgatactg atattttaga
    31021 taactatata ataccttgct atgaagcact acattctcaa agtaaaggtt acatagtgga
    31081 agatttaatg caagtactta aagaaaaggg tgtgatataa tgattgtata tcatggttca
    31141 tattgtgtgg taaagacgcc tagtattacc ttttcaagag attctttaga ttttggaaaa
    31201 ggattctatg taaccagtat aaagacacaa gcaattaact ggacagagcg ttttaaaaaa
    31261 agaggtaaaa aagcatattt aaatagttat tctttagata ttgataaatt aaaagaaaac
    31321 tgcaaggtaa aaatcttcga tagttataat ttagaatggc ttgattttat aatagaatgt
    31381 agaaatatga gtgatatata tatgaaatat gacattataa taggtggtat tgctgatgat
    31441 aagatttaca atacaataga actgtatcaa gataatctta ttgaaaaaga tgaagcttta
    31501 aaaagattaa aatactataa accaaatgaa caaatatgta taaccaatca aaatgtaata
    31561 gataaatatt taaagtttag gtatgaagag gaggtataat gattatggaa gcaaataaaa
    31621 cattattaca aatactatat aaaaaaatca tattagaatt ttccaaacaa acaggtaaga
    31681 gcttggaaga aagtatggat tatttatata cttctgaaac atataaactt ataagtgagg
    31741 gtgtatcaga tatgcactgt aagggtcata tatacttggc tcaagaatta atgttagaaa
    31801 atggattaat gtaccataag ggctatccaa gataaataat taaaactaga tacgaaataa
    31861 ggatacaata taatataaaa ttaatttgta tccttatttt gattttgtaa ttaactatat
    31921 gaaatcacaa tatttatatg tatttgattt ttacaatgaa aatattttat ccaacttttc
    31981 tacagcttca actttcttat cttccataac ttgagtatat atattcaaag ttattgatat
    32041 atcataatga cccattaaaa cttgtacagt tttaggagga acatcattct caaaaagtct
    32101 agtagcataa gttttcctaa gaccatgaaa ctttataggc tctatattta agctatttaa
    32161 tatagacttt aaattcctta aaggtctttt atcatctata gggatgccta attcattgca
    32221 aaatacataa ttattattta tatataattc tccagccttt aatatatctg tattttgatt
    32281 tactttatgc tctttcaatt tatttaaaac atcttttgga ataggtacag ttctgtaaga
    32341 atttgatgtc tttggccctt gctctaatac tttaagctct ctatttccag ttttatctat
    32401 aaaatatgtt ctttgaagag ttcttttaac tgttaaatta gactttttaa aatcaatatc
    32461 aaaccattta agtcctaata attctcctaa tctaagtcca gtaccaagag caagtaaaaa
    32521 taatacctct aatttatgcc catctatagc ttttataaaa ctcttttgtt gttcaagagt
    32581 caatatttca agtttgtttt cttttttctc aactggtata tttaccatag tacaatagtt
    32641 acgttgtata agaccttgtt tttcagcttc tgataagcag gttttcagtt tagtgtttat
    32701 ttgccttata gtaggtatac ttttattgga atcaagcaat ctattgtaat atttttgtat
    32761 gtgagatact cttaagtact ttaatttaac attgcctaaa tcagtatctt taatataatt
    32821 acgatagatg ctttcatatc tttcaaatga cttgggtttt aaatctttta ttctatattc
    32881 aaataaccaa ttgtaaaacc aatgctctaa agttatttta tcatctgaaa tatcagagct
    32941 taaataatat tgttttttat aagcatctaa tttatcttta acttcctttt gagtcttacc
    33001 ataaaattct tttctcagtg gtttaccatc ttcattatag ccaatcatta tacgggaacg
    33061 ccaaccatct ttatattttc cgatagagcc ttctccatta gctcttttag ttgccatttt
    33121 taaacagctc cttatatgat ttatagttat atccatcaaa gaatgtaata catttctcta
    33181 ataagaattt tataacttca tcagcttcta gtgtttcata gaagtttagc attaatgtgt
    33241 tgtactcttg tttatgttta gctggtattg atagaactcc tatatcatta tttataagta
    33301 ttaggtttga ggtaagtcta gcagttcttt tgttgccatc atagaagaat tggcaatagg
    33361 acaaccataa atttattatt atagcctttt ctaatgggtt agttatttta tttatgatat
    33421 ttatgtcatt tacaaataaa tcatttaata gagtggcttc tatgcattca tattgagtag
    33481 taccagctat acctatatta ccatttctga aatctccaac gattagagct tcatcttttg
    33541 caactatttt atgtatagag caaattgtat ctttatttaa agataagttt tctttgttac
    33601 ttaattttat tacataatcc catgatgatt ttatatttag tatttgattt tggtcactta
    33661 atttatgtcc gcctacggtt ataccatcaa gtaatgtttg tacttctggg aatgtgaagg
    33721 ggttattttc taggttaccc atatcatata caaattcact tatcattctt ctaatgtatg
    33781 ttaaagtata ttttttatct ccatgaggta tattagtagg gaatttatgt gtgtattttg
    33841 gtatatatga tttattcatg attttagctc ctttcatatc taatttttat ttattaacta
    33901 tgaatgtata aaagttaata ggtaaactca tattttgaaa atgtgcaata ctaatattct
    33961 tcatcctcat cttcaataag accattagag ttttcttgta taaaattttc aacaagacca
    34021 tttatcaccc aatttagatt tttggagaag tctttgaagt cagagaagtt taggttaatt
    34081 ggttttattg tatctgcatt atctgtaatt tcaaactttt ttttatagtc tgtttttata
    34141 tcataaccat aattttctaa tatgtgaatt actaaatcca actctttatc aaatactttt
    34201 aaattaatat tattatttgt taaagtatct aaatcatttt cttcaacaat gagtttattt
    34261 atagcaattg ataaagcagt agctattttt cttatcatat ctaaactagg cattctttga
    34321 ttttgctcat atttagctat agcatgaact gaacaaccaa tcttgttggc tagctcatcc
    34381 cttgacatat ttatcgattt tctatattgt ttaatctttt ctccaattgt attattcatc
    34441 ataatttcac cttaaatata tcatcaaaca atgattgtac ttctaaacat gtaaaggagt
    34501 tattttctag attatcccat atcatatact aaattactca taactctctt agtgtatgtt
    34561 agagtatatt ttttatctcc atgaaataaa ttagtagggg atttatatgt gtattttagc
    34621 atatatgatt tattcataat tgtaactcca ttcatagttt tttatcattg ctttagatag
    34681 tattgatatt attttatatt ttagttagta gtttttttat ttctttaagt gtattttcaa
    34741 gcttttcatt tttttccttt agttcgttat tttcttgtaa taatttaaag taatcattat
    34801 ttttaatagt aatattttct ttttgagata ttaatttttt tagtcgaata ttacttccat
    34861 tatctgttga gtcactaaag taatcataga ttgtttctat actttcttct gatagaccaa
    34921 tatctaataa ttcatcaatt gattgttttg taagaacatc atttttaata atttctttta
    34981 tgtcatcagg atgtaatgaa aaatctaatt cagtattaga tatacaatct gaaagtatcc
    35041 aattataaac ttgattttca tttagttcta atttttcacc aagtttataa tattggtctt
    35101 tatcagacca ggcacctagc aataaacttg aggtaattct aatatcatct tccataagat
    35161 ttgaaatagc atttaaaaat tcatcaaaag aatagtattc ttctgggaat aaagactgta
    35221 aaaggtataa aacatcttca ttagtcatta cttcattttc aatatcaaaa taaaagatag
    35281 tcttttcaat tttcaaagct ttagcgagtt ttgataaggt atctatacta ggtattcttt
    35341 tatcattttc ataatttatt agagcatttc ttgagatgcc actaatttca gcaagttgaa
    35401 tctgcgttag ctctttttgt tttcttatct tttttaagtt ttttccaatt tgcaatatta
    35461 tcacctcgta taaagtatat cccaaaagta cacaaatgag aacagaaaaa taatatattc
    35521 ttattaacag tacacatata tcgacattat aattaaaatg taaagtttac gaatgtaaac
    35581 tagaaaaaag gaggaaaaag tatgggaatc aatttaaaaa tatttaggat taaaaaaggt
    35641 ctaaagcaac aagaactggc agatagagtt ggtatatcaa gatattattt atcaaacttg
    35701 gaaacaggta aggctaataa tccaagcaat gatttgatga ttaaactatc tagagcttta
    35761 gatacaacag tagaagaatt attttttagt aaggaggatt aaaatatgaa agagaataat
    35821 aatttagagg ttttaaagac attacaagcc actttaaaca ttattgtaaa gaatgaagaa
    35881 gaagcacaag aaaaaaagca aggatataaa attattgaaa atgcgaaaag aaataaagct
    35941 gagcttataa catgtaaaga agcatctaag ctttatccta taggagaatc aaaatttagg
    36001 cagttatgtc attctaaaaa caaaggattc ccttgtatat ggataaataa tcgagtatac
    36061 ataataaaaa ataaattaga tgattggttt attgaaaatg caaatggtat caagttatag
    36121 tcttaaagta ggtgtttgca attgagcaat aaagggtgga taaagcttta tagggagttg
    36181 ttggataaat caatttggaa agatattaaa ccagaaagaa aggtaatatt aataactcta
    36241 ttacttatgg ctagtcataa agaaaatcat gtttttatag ataataaaaa gataaaaata
    36301 aagtttggac aatttatttc ttcatatagc aaaatagctg aaagatgtgg taaaggagtt
    36361 agttatcaaa tggttagaag ttgtttgttg gtttttaaaa atgctggttt tctaacatac
    36421 gaaacaacaa acaagtatat agtaataact attgaaaact gggagcttta tcaagagaat
    36481 atagaaaatc aacaacctaa tcaacagact attaacaatc agtcaacaac aatcaagaat
    36541 ataaagaatg aaaataatat tatatatagt gaaatcataa gcaaatttaa ctcaacttgt
    36601 attgaacttt caaaggtcaa gaaactaaca gatacaagaa agaggagaat aaattcaaga
    36661 ataaaagaat atgataaaga aactgtatta gaggttataa atatagttag taaaacaagt
    36721 tttctgaatg gaaataataa tacaggatgg aaagcaaatt ttgattggat aatgaattca
    36781 agtaatttta ctaagatact agagggaaat tataatagca aggaaattgt cataaataaa
    36841 gagacaggaa tatataatcc agatgactca caattaaagt ggtaaggagg ttatattata
    36901 aataattcaa acaacttaat taaaaataca gaagcagagc aatcaattaa attacactaa
    36961 gttagttata aatctttcat atatttgttt tttaagtatc tctaatatcg tttaaattac
    37021 actaagttag ttgcagatat accagaaaat atatataaaa ttatgcgtaa actatattgt
    37081 tatgagtaca aataatattt acctattcat taaaaaactt aactaagaat ttaatttata
    37141 ttattgaagt atcaataatt ttggaaagta gaaaattata ccccaataat accccaacta
    37201 caaaaataga caataaaaaa taaccagaaa aattgcttca acatcatgac caaatagcca
    37261 tatacctata cttataaaaa ccaacaaaac aatcaaataa ccacttataa attctcctcg
    37321 gtctccacca ttggaatcca cgaaaacata ttgatttaat agttaatatg ttttttattt
    37381 tgaaaaatca tatataatat aaattaatag tttatttaaa aatttcagta tgagcacaaa
    37441 attatataat tattgggaat tagttataat aagtaatttc tagtaagaat gatttgcaaa
    37501 aaataataat ttaaatacaa aaaactaaag gatagaagtc ataaaattaa cttttaacct
    37561 ttagttatat aaataaaaaa ttagttatta ctaaattaaa attagatttt taaagaaccc
    37621 aatatctcta ttatccatat caccaattaa catgcttcta tcaagtaata aattatactc
    37681 ctcacagcta gtttcaggca ataaagtaca tgaatggcat gctcctagat ttaaagaatt
    37741 tctaccttga ccagtactat caatacatat tgggtcatta gaacaccaaa gagcacgatt
    37801 aagagcacta tttaatatag atggtaatga atcatgcata ccttgcctaa ctaatcctcc
    37861 taaagtacct tcagagtcac cacttgcagt gtaaactaaa attccagaca taactttttc
    37921 attttcggaa ttattacaat atatacgttc cctaagtgaa gaggtagcat atccacaaac
    37981 aaaactaagt tctcttataa ttaaatgagc taaagtatgt agtaataaga atttaggtgt
    38041 aatttttcta taagctttgt cattaacatt aatatcttta ttatatctag aatttaaaat
    38101 agatgcatta tcctgtattt taggattaga tgaaatccag ctttttacca tatcattatt
    38161 tatctctatg aaaatacctt cacctctaac ctcagatgca ggataaaaag attttttaca
    38221 atctctagat cttaaactta taaccttagt atcattacag ctatcatcta tatcttcttc
    38281 accaaatata ttattatcag gtggattgac tctactaaac ccagttaatg cccttacttc
    38341 tctaagtctt tttactaaca ctattttact gaagtttgga atatcataat cagatagatt
    38401 ttgttcttct attgtaaagt cattagtttt tttagattta gcatctatat ttccaattaa
    38461 agcctcatat tcttcttctc tatattgatt tctagttgtt gttgatggtg aagaatcttc
    38521 aaaaggcaat aaatctttca aaactatgga tactttatca gtatcaaaac ctgtttcttt
    38581 agcaatatca ctggcaaagt cctcaaaatc ctcatccata aagcgttcta acttattctt
    38641 tttaatagca cgatctaaga atttcttaaa tgtatcataa cctttactag atagcacttt
    38701 agaattaaga gtatcagagt atggtggtat aataattgaa ctttctatct taggataata
    38761 tacattagag gcacctcttt gagaagcaaa tgaatattta gtgcatttat ttactttttt
    38821 attataccaa ggcgaattac cagagcattt aaacatttcc ttatattcac taggtacacc
    38881 ataatcatta gatttagaag attttaaacg cataaatgcg cccttcatat tagctttagc
    38941 tccacagcta cattcaagtt ctataccttc taatcctagg ttactttttc cagtcttcat
    39001 taatatttga ggattttcac aaatttcttt tcttccagat ttatttctaa aatgaaccca
    39061 ttttacccat ggaaaatcat caatatgacc atgttcacaa atagtaatta taccagtagg
    39121 tactaattgt ttagtagact tttttgtgct acaagtaagg caaataggta ttttcatagg
    39181 tttatcttta tgagcatttt tataaagttt ctcccaatct tctataggca taaattttct
    39241 acattttgga caaaagtacc atctaggaaa cctaacaaaa ggaacagaag atctatcatc
    39301 tatagttgga ggtgttctta gttcattaac cctcaatgta gcctgaagcc tatcatcttg
    39361 tattttaatt gtattagtcc aataatttgg atgagcagtc attaatgttt gatcaataaa
    39421 atctagcata gctcctggtc caaaaacact tgtagcttga tttattctta aattatgagt
    39481 tttatcatct aattttatag acatattaat tttcctccaa ttctataatt tcaacagtac
    39541 attgtttatc aacatttctc atagaattta atgtttgttt ttcatttgta ataacatcct
    39601 tatcataagg aattaaaaga ttattatata ttttattatc aaatttacta gggcgcttat
    39661 aataatgcaa taaattatct ttatcagata tttgagcttt atcatgccat aaatccatta
    39721 taatatctaa ttcagatgaa atctcagatt taaattcatt tactatatta tcatcagcat
    39781 tttgattatt ttctctaaat atatcgatag atctatctat tatgaagttt tttaaatctt
    39841 ctacaccatc catatttttt gaaaatcgac ttgcaagatc attagcttga agtcctaaaa
    39901 tatgtctaat catacttatt aatactgcat gcatgcctct ttctctagct ggttcagaga
    39961 aaggtgtaat actagtaggt tcaacaaatt tatagaatga ttgatgataa ctaaagaact
    40021 gttcataatg agatctatct cttgtttttg taggattata taatgtaaat ataagtcctt
    40081 cattacttct accaactcta ctgctagctt gtatgtattc agatgttaac ttaggctgac
    40141 caactactac cattaaattt aatctatcaa catcaacacc aactgaaatc atattactag
    40201 ctaatagagt atcgacagtt aaattattag aagtaagagt attagatagt tcatctaaag
    40261 ttgtatttat cttagtagaa gtaagtctac tagtaagctc tctttgttca tttaggttcc
    40321 ttaatgattg ataagggtgg gctgagactc ttttacataa tctttccatg ttgtctttta
    40381 tatcgtcatt taaaagtgtg ctacacttac ctaattctct gatactatta aaataagata
    40441 ctagtgtcca atatttatcc aataaattca actctacatt ctccatcatt ttaagtcttt
    40501 ggagtaatgc tgacataagt ctaacctcta cagtaacttg agtttttcca gatggaataa
    40561 cacctacata tagtcggcca cgttttttac ttaaaggcat ctctttaaca aagaaagagt
    40621 tactagatgt taatcctgga ggtggaaact gagctacatt acgattatat agatttttaa
    40681 cttgattttg tgcttttctt atagtagcag tagaagctat aatcttaggt tttataccct
    40741 tatagctaca catagcatca agtgcagttt catataaacc taccatagta cctaaaggtc
    40801 cagaaataag atgaagctca tcttgaatta ttaactcagg agataagttg ctattatcat
    40861 catctaaagc aaaaagacta gctacttctg tagtccaagt tatcattgca aatttatcaa
    40921 ctgtaccaaa taaaagtgtt ggagggttat tataaatctc ctcatctaca acttgtatag
    40981 gtaacatatc ttcaaatgaa caatcttctt caggacagca taagtagaat ttcttaggtc
    41041 tagatttaat tctatagccc caatcaccaa cagctttttt agaagtttta tcccattctt
    41101 taacaagttt tgttccacac caaggacatt ttagtaattg gaatttatta tattttgatt
    41161 ttaaattatc taactcatat tcactattta tactagatct aaacttaatg ttattacctg
    41221 ttaagttatt aagcatttct tctgcctcat cattaaagtt tggagtttga tcactcccaa
    41281 tccacaaacc aatagaaatc tcttttttcc caagttcaga cttattttct tttctaataa
    41341 tttcacaggc acaaattaat atacttgctc ttatgaattg ttgtgcagcc aatagcctta
    41401 gtgtatatct cattatgata gctgtaccgt taccattttc tttgtttctt attcttctta
    41461 agaagatagt aaaagcagat agacctaagt aggcctccgt tttacctcca ccagtaggga
    41521 tccaaagaag gtcaactaaa tctctatgtt tagagtcagg attttctatc gaagataaac
    41581 atgtaagtat ataagcaagc tggaatggtc tccaagcaga attatcattt gagtaatcta
    41641 tatagtcaag gttattagat ccagggagtc tatccgtaat atgtatagaa tgacatcttt
    41701 gcataagtat agctctattc attagagaaa atgctctgta tacttcatca ttagacttaa
    41761 ttaaatttat accttctagc attctagact tagtatctct gcagtttttt atatgctcat
    41821 atgctacatc tttaaaaaca tcactaagat cttttgaatc ttcttctaga tcatctatcc
    41881 aaatatcata agcatcaaca aacttataaa gaaaatatat tttcttatct ttactaagat
    41941 cagagatatc tgataaattt ttcatagaca gtaattctct agaaacatca cttaattcat
    42001 ctacattaaa gtccaattta ggtacttcaa aatgaggaat aaactcagta caaagtttta
    42061 ttaaagcatc attttgaata tcttgatcta tagctacacc atgaccagta gcaaaagttt
    42121 ttttatttcg gtaaagtaag tctaaagata tttcctcaga atctaacttt ttaaaagtat
    42181 ttactgatcc agctgtaaaa atatctataa actctaaatc attgttatct tcagctaata
    42241 ccattagttc aggctggaaa atagtattat tatatttctt aggcccagat tgactattaa
    42301 ccagcataca agtaatacta acaaagtcat ttgaataaat tcttttagat aaaactatat
    42361 ctaaatcttt agatataggt tttttaatat agtttttatc catatctatt gatactatta
    42421 agttttcatg tggaacacga acataaccac cagtcttatt ctcatcatca gggcattggt
    42481 tagctaactt gtataaaaca aatttagctt cagcattatc aagtaaatca tgctttttta
    42541 gtaaattata aaccttctca gatgttagtt tttgcttaag atataggaat gatcccctaa
    42601 gttctacata ttcattaatt gtattgctag aatagaagtc gtcaccagta tatttaacat
    42661 gacagtctgt atataaagca tttctataag tagcataatt taccctgaaa tttattactt
    42721 ctgcatcttt ttttaggaaa aaagtcatac ccatagaaga aggtaaagtt tcattagaca
    42781 tacttatagc tctatctagt tcattttgtg tatcatctga tgtaaataca ttatcttcac
    42841 catcatattc agatgtatta cttacatcaa tattgttatt aagtggatat aaaatacctg
    42901 ttgaataacg ctctattgga ctatctgtta ttatttcata ttttatattt tcacaaagat
    42961 cttccgaacc aggtccaaga agttcttttc ttacaagatc tagggtttta tctcttagtt
    43021 cactacaatt catatttacc tcctatttat ttaataaaca ctatataagt ctaaaacttt
    43081 gttaacaagg tggggtgaca gatacttatc acaactgtgt atttctcgta tttgtacagg
    43141 tgtaacataa tcatttgtat tcccaagcat acttaaaaca actgcagaca cttcatcttt
    43201 aattatatct gatttactgc taaagaaatt atcagataca aatgtatcta tagatttttt
    43261 tattttagtg tgcaaagagc gtatactttt agtagcatca tatacctcgg tatgatctaa
    43321 tttagaatct ataactttaa atatcttttc gaaagttttt aaatatatag gacctattaa
    43381 tcttttattt gttacccagt ttttgattgt tataggatta atcttttcac ctaaaacagc
    43441 taaactgttt gatacatcat tataattata tttactataa gatatatagt ttttaagttc
    43501 tgatttccat gaattagtta atttataatc atcaagataa tgagatggca ataaattaag
    43561 ttctaatagc ttttgtataa cattaataac taattcaccc tcttcattta agtaatcatc
    43621 aacaaataaa aaccagtcat taactttagc ctctgaaagt ttctttttcc taacactttt
    43681 tttatcccaa tctattgaat aggctattgc cttttttgta cagaatatat actcattatt
    43741 atcagaaatc atgaatgatg taacatgttc ttttttagag ttgtaaatcc cttgatttat
    43801 agatagagat aatataattt catttaaatt tatatcaaat ttataattag atatatattc
    43861 atccatagaa tcatcatcag aaataggact atcggtagaa taagcttcta atttattggt
    43921 ttcataagtt ggtttaaaag gttttatatc aagtaagtta tatattttat tatttttttc
    43981 aattttattt cttgcagaat ttatttgatt catatagtaa ttatatttgg ataattcact
    44041 attatataaa tacagtgtaa tatttataat caaatcacta tttaaaatat ctaaatattt
    44101 caaatcatag aatccaaaca taataagatt ttttattgtt tttgaatctt taaatttttc
    44161 agcagaaata acttgtaaat ttatatttct agattttaat aaatttttaa gtataatagc
    44221 ttcatattgt ttttgtagca atataacagg tgtatttggt gtaaatgttt tgtatttata
    44281 tgaagatact aatttattta gtgtattgaa tttggtatta ttatcagata attcatttat
    44341 aattctttca aatttgacta taacatcatc aaataatgca cttaattcta aatctgggct
    44401 agtacttgaa attaaatatt ttatattttc tagcttcgct gaaggagttg ctatatttaa
    44461 atttaaaagc tttatagttt cttctaaaaa atctaggtta aaaggtgtat tttctaagat
    44521 tttaagaaga gagtaactac acatcataag tgagtttttt atggaaatat caaaatcata
    44581 cttagatatg taataaagtg attttctagc ctgatgtatc aagtcagaga tattagaatc
    44641 aacagaagta gtacatatat ttttatttat aagtttatct agccataatt tctgaaaagt
    44701 agaggtattt tcaaaatctt ggctataggt taacagaaca tctttagacc aagagtatat
    44761 atttagatta tctatatttg gtaaatctaa tatattgctt atatttgaat ttgaggttac
    44821 aatatttaca ctttctatcc tttttctatt taaaattctt tcaaaatcat ttatatgctt
    44881 ataaattgga taatcaccta ttataaatac attttttata gacttatcag atttaataat
    44941 ttcaaatgca ctagaaatat tagttgtaaa tttaagtaaa ggtatttgct tagcgtgatt
    45001 tccaggataa tcagtttcgg caccagttga tgaaatatat gaacatggaa atagttcagt
    45061 aaacttataa gtattattaa tatcttttat tttaatatta ctaactaagt cagatatatc
    45121 atctttacaa ggcaatataa tcagtgtaga atcatttatt actccagtca tattttttaa
    45181 gtctgaaaaa cctaaagatg atagaacatt ctttgtttga aaagtcttag atgctggagt
    45241 tttgcccata gaattgactt ctaaatgacc attataggtt ataagcatat aagccgagtc
    45301 aataggtata agtgttgtat ccgttttatt tttatgtcct aaagttatgt gtgtattatt
    45361 tatattttta aatataacta tttgaccctt gtagagcagg ggcatacctt tatcgagttt
    45421 tgtaagaatg tgattatttg ggtttaatgt attatttaag tatgagttta tagctatatt
    45481 caacaaataa atagcatata tgtatttgtc attataattg ataattaagt tattattttt
    45541 ttcatttata atataattta atacattaat attatcttga taatacttag aatttgttag
    45601 cctttgttta ttaaaataaa tttcacatat atcattatca agaatataat ggatatttgt
    45661 agttaacatt taaatctcct ttagtagtta ctattgttta ttagaatagt ttttattcta
    45721 tattataatt atattactaa aaaataatat atggtatata atataaaaaa agattgataa
    45781 ataaataaaa aatatattat gttatttatt tgaatagatt atccagaaga cataaataag
    45841 aaaaataatg tgtaagtaaa aatattagaa tttattaaaa gctattacaa gtataagaaa
    45901 tttgaaatga ttattcaaaa attgacatgt gaaaaaaaat atgatatgct gcaataaaag
    45961 ttaatgtgag gtatgtcaga atgtataatg ttatagatct ttttgcaggt gcaggtggtt
    46021 tgagcttagg atttgaaatg actaaaaaat ttaatatggt ggcttttgta gaaaaaaatg
    46081 ataacgcagc aaaaacatac cttgaaaatc atccgagtgt taagcgttat tgtgatatta
    46141 aaagattaga ttttcaagat atattaaaca gtgtcgataa gatagatgtt gttataggag
    46201 gaccgccatg tcaaggtttt tctaatgcta atagacaaaa aagaaaaatt ataaatggaa
    46261 ataatgaatt agttaagcta tatgttgatg ctattgataa attaaagcca aatgtatttg
    46321 taatggaaaa tgtcaaaact atatcttcaa ataagcattc attttatttg actaaaaaag
    46381 ataaaaatca tataataaat aatttaaaat taaatattta taataaagat agtgttttat
    46441 atgatagaac tgagtatata aatgaattat ttaatattat tagtatagaa gatattgaat
    46501 catatattat atcaaatata gacttaaaaa atttgaaaat aattattaag aaaaaaaagg
    46561 atatatgtga ttatttaaat aaaatatcta attataagaa agtaaaatct accatagaaa
    46621 aattggaaac aaggggaaaa atgccaaaat ggtatttaga attaataaat aaagtaaaaa
    46681 atatattaga aaatatgtta tataatagaa atttatcaga tgaacaaata ttttatttga
    46741 acttattctt ggatattcaa aatttatttt taggaatata tgagttaaaa tctgaatctg
    46801 taattttcga aaatacactt gatgataata aaattatagc taaaatggat acttacatta
    46861 taatagatta tataaatgca tcctttgagt atctaggata tgtattaaat ggaagtgcac
    46921 taaattcaat tgattatgga gtacctcaaa atagagaaag atttgtattg ataggagcaa
    46981 aaaaagactt cttaaaaaat aaaaagatag aaactcctaa gcctatagtt ggagaaaatt
    47041 atgttacagt aagagatgca ataggcgatt tagctgaata tgaggcttct aaaggtagta
    47101 tggattattg ttttgaaaaa aatagtaata atattgaaaa agatttttat agaaagataa
    47161 tattggatag caataaaata tacaatcatg tatgtacaga tacaagaaat atcgcactaa
    47221 aaagatttga atatataaat caaggaaata attttcattc tttgccagat gagttaaaag
    47281 gaacttatgc tgatccagaa agaactcaaa atactattta taaaagacta gtatatgata
    47341 agccatcaga tactgttgta aatgtaagaa aatctatgtg gatacatcct attaaaaaca
    47401 gagctgttag cgcaagagag gcggctagat tgcagtcatt ccctgatagt tataagtttt
    47461 taggtacaaa agattctgta tatcaacaga taggaaatgc agtaccacct ttattaggtc
    47521 gagtagtagc agaaaagata ttaaatttat ttaatgatga accaaatgag tatcttagag
    47581 atgtgtttga agcactagat ggatagttca aataaaatag tgggtattat tcttgtgatt
    47641 cttatccaac attaatccac gaaataagga ctgtcgaatg agtaatttta aattgctgtg
    47701 cgacagttct ttttttactt gcttttcatt aatttatatt tatgcaaaat ttgagcttga
    47761 aaacggtcat aagaaataaa ggtataaaaa tacaatttta aaatagaata atttacaaag
    47821 tgtaagatta aaaaatattt ttgagaggat gaatatacat actacattta ttaatgatta
    47881 tcttatttgt gaaacttaga aatactatag gctaacacta caggtataaa ctctgaaaga
    47941 atattttgat tgcctttgat tagaattctt ttaaagttca tactatgttt tatttgggtg
    48001 aaagctcctt atgcctgaat acttctattc attctaagtt cacatccttg tgtaccagtg
    48061 attctttcta aattatctta atgccaaaat cttgttcgca tttcaaaata aagtcaggta
    48121 gctacttcaa cattttagtt atatttcttc aatagtttgt ctccaaacaa aggtacatct
    48181 attagaaaca gatttaattt tatttatatc aataaataat atatactttg aaacttcatt
    48241 aatatcacca agataattta taagttaagc tattatatac tatcttcacc aactacatcc
    48301 tccatagttt tacactttct taattcagct tggtaatcta aatctgtaat aattatttct
    48361 ctttgatttt tcatttcttt gcctacaaaa gtttaatata aatattattc catacttacc
    48421 aattttacgt tcaaaaaaga ctgtagataa gtctgcattt acacaaacct acttataggt
    48481 ctcttttttg aaattaattt agcatgaact atagtaagag catctttaaa ttcatagtta
    48541 caagtataca aagttataat tttatctgaa atatctacct ttatatcaga tttgtgtact
    48601 gatttttagg ttatataatt caaagaatat ttaaactcat cattattatt aaagtgtata
    48661 cttaaataat ctctgttaat taagtcagca gtatatactg aaaaaatttc ataagtataa
    48721 gtttgtactt tataatttat ttctactaag ttattttctt tgaaaaatac ttcatcagta
    48781 tagttttcta gttgaccaaa catagtttta tttttcatat aatgaccata gactattaaa
    48841 ctcttatcat tttcaaaatt atttctataa tccatgaaaa tactacctaa aggaagat
//
LOCUS       DAEPID010000026        47872 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.026, whole genome shotgun sequence.
ACCESSION   DAEPID010000026 DAEPID010000000
VERSION     DAEPID010000026.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 47872)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 47872)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..47872
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.026"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            29..910
                     /locus_tag="KR257_001601"
     CDS             29..910
                     /locus_tag="KR257_001601"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729426.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4300 family protein"
                     /protein_id="HBH0030306.1"
                     /translation="MKKRLIIMILSVVLVLSSILTIFAYSNIKYNNNKLIYSNMIDKK
                     TQNSVKEILKENKINEKDIDTFIKAVNNYNKLQVKILQNNINISKSGYSSINAKQVPY
                     NLEKLQDNWVKKFPDYMDVNCRITAFRLFKDFINSNKKFTGDSIDLNVDLDTIMNNKD
                     AKFSIKDVEKFINFFSAIPAKDTDDTIKISEQIKNEWKKRKISFKNNKNISIINGFLR
                     YPETKNVFIGHTGICIKTKNGILFLEKYGVTSPYQVTKFKNKEDVKNYMFNRLKMSEG
                     EIELPDPIIMENDKLMK"
     gene            complement(1223..2002)
                     /gene="hisJ"
                     /locus_tag="KR257_001602"
     CDS             complement(1223..2002)
                     /gene="hisJ"
                     /locus_tag="KR257_001602"
                     /EC_number="3.1.3.15"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902127.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="histidinol-phosphatase HisJ"
                     /protein_id="HBH0030307.1"
                     /translation="MKDGHIHSPYCPHGSKDDFEKYVQRAMDVGITEMTFTEHFPYAN
                     GFRDPAPENDSCMSIEDLPKYFNDVKKLKEKYEGKIKINVGSEVDFIEGYEEGIKENL
                     NKYGKELEDSLLSVHIIKIDDDYYCVDYSVEEFQNLIDKLGSIEAVYNKYYETLIKAV
                     NSDLGIHKPKRIGHLNLVRKFNQVFPYDYKGNTILEELIKLIKEKGYELDYNVSGNRK
                     EYCKEPYIDGYLLELVKKYDIPLILGSDSHCAEEINKYDIV"
     gene            complement(2548..2898)
                     /locus_tag="KR257_001603"
     CDS             complement(2548..2898)
                     /locus_tag="KR257_001603"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418378.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="zinc transporter"
                     /protein_id="HBH0030308.1"
                     /translation="MIFDKEIVRYHHGHHDHDHCHEHTHGDICHEHPHDHAHDHDHEH
                     SHEESSESKDEKTLKILLVHWINHNETHEEGFREWVEKARAIGKEETAKSIEKAIEYM
                     EEANKMLLEAKKHM"
     gene            complement(2914..3330)
                     /locus_tag="KR257_001604"
     CDS             complement(2914..3330)
                     /locus_tag="KR257_001604"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418377.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3842 family protein"
                     /protein_id="HBH0030309.1"
                     /translation="MIIAVIDGMGGGIGAQIVSSLREELPTYVEIYALGTNSIATSSM
                     MKAHANKGATGENAIVVSAKKANIIVAPISVIIPNSMMGEVTCNISEAIADSEALKIL
                     LPIMPENVELVGLEGKPLALLVKDSVNLIKKEFNIK"
     gene            complement(3349..3540)
                     /locus_tag="KR257_001605"
     CDS             complement(3349..3540)
                     /locus_tag="KR257_001605"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418375.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CooT family nickel-binding protein"
                     /protein_id="HBH0030310.1"
                     /translation="MCESSAFICKSNNELEKVMENVVNIDPCDGKIYLTDLLGEQKII
                     DGIIKEIRLMDHKIIIQEN"
     gene            complement(3691..4506)
                     /locus_tag="KR257_001606"
     CDS             complement(3691..4506)
                     /locus_tag="KR257_001606"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436933.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="lipoate--protein ligase family protein"
                     /protein_id="HBH0030311.1"
                     /translation="MNQWRVIHNKSYEGAMNMAIDEAIFTAYKKGHNKPTLRFYTWEP
                     ACLSIGYFQKLEDEIDLDKCRCMNIDYTRRITGGRAVLHDNELTYSIIIGEDNPLIDK
                     SINLSYRYISEGLVKGLNLSGIETDNLNRGERISRENLSAACFNAHASYEVTINNKKV
                     IGSAQSRKDGVLLQHGSIILDFDVEKLFKLIKTKTPELKERAMKFTAKKASGIENEIG
                     RKIDIDILQKNIVKGLAEQFNVEFVEGDLTDYEKQLVKELYEKYKNEEYNKKR"
     gene            complement(4553..5491)
                     /locus_tag="KR257_001607"
     CDS             complement(4553..5491)
                     /locus_tag="KR257_001607"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729428.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="radical SAM protein"
                     /protein_id="HBH0030312.1"
                     /translation="MIRLSVGTAIELGILNKKSDIPPTTAYIMIGEKCINKCSFCSQS
                     IESSTRKDKLSRVIWPEFSKEEILDALKAYKGKNIKRICIQSMASEEAHNSVLDFINY
                     ISGKIDMPISLSAKLENDEQIKKFFSVGVDKIGIAIDAANKELYEKIKGNNYDEKLKF
                     ITEMSKSYPNKISTHIIVGMGESHEDIYNLYTYLKENDVTISLFAFTPVRGTKMEKIN
                     QPSIESYRRVQLMSYMINKGYPKEYFKFKNGYLNSIKLDNDILKDINKGYPFEIRGCK
                     DCNRPYYNERPGSTIYNYSRPLNQSEIDLAIREINL"
     gene            complement(5488..6360)
                     /locus_tag="KR257_001608"
     CDS             complement(5488..6360)
                     /locus_tag="KR257_001608"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418368.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="radical SAM protein"
                     /protein_id="HBH0030313.1"
                     /translation="MNKNLSEKMEIAFDIKLKNFGNKIEFAYPNQTLALSTTSNQCSL
                     KCAHCNGHYLNNMVPIEEYEEKVQSRNITSFLLSGGCSYEGDVPINTHINTIKNLKEQ
                     GYRLNAHLGLMDKDSIVELCKYLDIVSFDLVFDDETIREVYKMKKSKEDYIEVYNTIQ
                     EHTEVAPHICIGLKGGQIKGEYEIIEYLQKNPPNKLTFIVLIPTKGTEYENVEPPELE
                     GVADILCEARINLPDTEINLGCMRPRGVYRKELDQLSIMCGVNRIVLPSRSAKNKAIE
                     MNMTINECKECCVL"
     gene            complement(6385..8313)
                     /locus_tag="KR257_001609"
     CDS             complement(6385..8313)
                     /locus_tag="KR257_001609"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888540.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4445 domain-containing protein"
                     /protein_id="HBH0030314.1"
                     /translation="MIKVSFTPNNKEVYCNEGDILLEVARNADIFIDAPCNGNVSCGK
                     CKVKLLNGKVDTEKTRHITDDEWEQGYILACCTKVISDIEIEVPSKVSSSMHGMKIEG
                     SNKKEDREIFERAKKIIEEHNLQFKTNIKKKYIEMEEPNLDDNISDVDRLERYVRNNL
                     GYNEIDFRLDILRKMPTVFRKSDFKVTITYVQKQKKLTIINIEQGNKENSLYGVAIDI
                     GTTSVVVCLVDLYSKEVVDKASSGNAQIKYGADVINRIIYSTKKNGLETLHKAIVEET
                     INPLLKTIYERNGIDKEDVVTLVAAGNTTMTSLFLGVYTDFLRQEPYIPPFLKSPKLM
                     GENVGLFVNDSAYVYLAPSVASYVGGDITAGVLSAGIWSSEENVLFIDLGTNGEIVFG
                     NKDYMMSCACSAGPAFEGGGISCGMRASAGAIEKVIIDKETLEPTLKIIDECAPVGIC
                     GSGIIDLICQMITKGVIDRRGKIYRDLDNKRVRFNEHEIGEYVLAFKEEFDLENDIVV
                     NEVDIDNFIRAKGAIYSGAYTLVDSLGMDFSILDRVYIAGGIGNNLDIENSIIIGLLP
                     DIDREKFTYIGNSSLVGSYLALISKDAKNKLEEIGNQITYVELSVYPSYMDEFISACF
                     LPHTNIEQFPTAKKLLEE"
     gene            complement(8425..8802)
                     /gene="gcvH"
                     /locus_tag="KR257_001610"
     CDS             complement(8425..8802)
                     /gene="gcvH"
                     /locus_tag="KR257_001610"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418363.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycine cleavage system protein GcvH"
                     /protein_id="HBH0030315.1"
                     /translation="MKLLPELKYSKDHEWVKVIDGDVVYIGITDYAQDQLGEILFVET
                     PEVEDTVTKGVDFGVVESSKVASDLISPVNGEVLEVNEKLEDEPECINEDPYENWILK
                     VKLADVAELDTLLSDKEYEAGLE"
     gene            complement(8889..11015)
                     /gene="cdhC"
                     /locus_tag="KR257_001611"
     CDS             complement(8889..11015)
                     /gene="cdhC"
                     /locus_tag="KR257_001611"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418359.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CO dehydrogenase/CO-methylating acetyl-CoA
                     synthase complex subunit beta"
                     /protein_id="HBH0030316.1"
                     /translation="MNLYNIIFTGSEQALGAAQAMLAEAIEKNGKEHKVAFPDTAYSL
                     PCIYAATGQKMNTLGDLEGALEVVKSLINRTHLLEHAFNAGLATALAAEVIEALKYST
                     MDAPYSEPCAGHITDPIIRSLGVPLVTGDIPGVAVVLGECPDAESAAKVIKDYQSKGL
                     LTFLVGKVIDQAIEAGVKMGLELRVIPLGYDVTSVIHVVSVAVRAALIFGGLTPGDLN
                     GLLEYTANRVPAFVNAFGPLSELVVSAGAGAIALGFPVITDQTVLEVPMNLLTQKDYD
                     KIVATSLEARGIKIKVTEIPIPVSFAAAFEGERIRKSDMFAEFGGNRTEAWELVVKKE
                     ATEVEDHKIEIIGPNIDEVDADGVLRLPLAVIVKIAGKNMQEDFEPVLERRFHYFLNY
                     IEGVMHVGQRDMAWVRISKDAFDKGFRLEHIGEVLYAKMLDEFESVVDKCEITIITDA
                     EKVSELKGEAIAKYNARDERLASLVDESVDTFYSCNLCQSFAPAHVCVVTPERLGLCG
                     AVSWLDAKATKELDPTGPCQPIEKGECLDDRTGVWNSVNETVNQISQGAVESVTLYSI
                     LEDPMTSCGCFECICGIMPEANGFVVVNREFASVTPVGMTFGELASMTGGGVQTPGFM
                     GHGRHFISSKKFAYAEGGPERIVWMPKELKDYVADKLNATVKEMTGIENFCDMVCDET
                     IADDSEGVLAFLEEKGHPALAMESVM"
     gene            complement(11072..11878)
                     /locus_tag="KR257_001612"
     CDS             complement(11072..11878)
                     /locus_tag="KR257_001612"
                     /EC_number="2.5.1.15"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418356.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dihydropteroate synthase"
                     /protein_id="HBH0030317.1"
                     /translation="MEKFMIIGERIHCISPSIRKALAERDPAPILKRAKEQLEAGAHY
                     IDFNIGPAERDGEEIMTWGIKLLQSEFNNVPIALDTANKKAIEAGLKVYDRTNAKPII
                     NSADAGSRFDLIDIAAEYEAMVIGLCAKEGIPRDNDERMAYCQEILEKGLMLGMEPTD
                     ILFDPLCLVIKGMQEKQVEVLEAIKMMTEMGLLTTGGLSNVSNGCPKHVRPVLDSAFL
                     AMAMANGFSSAIMNPCDPELMKTVKSCDIINGASLYADSFLELNEGGFAF"
     gene            complement(11928..13295)
                     /locus_tag="KR257_001613"
     CDS             complement(11928..13295)
                     /locus_tag="KR257_001613"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418353.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="acetyl-CoA decarbonylase/synthase complex
                     subunit gamma"
                     /protein_id="HBH0030318.1"
                     /translation="MALKALDIFKLTPKKNCKDCGFPTCMAFSMKVASGAVEVGKCPH
                     MSDDAIAKLSEATAPLMKALKVGAGASEYELGGETVLFRHEKTLVSRNRYAVSFCTCM
                     SDEAVDAKIANMKKVDYVRIGEQMKVEMAVLEYCGDKDAYLKLIDKIKGSGLEVAYIL
                     ACDDAQVVKEAVEVLKDARPMVYGATKENYKDMIEVVKGASLPLGVKAGSLEELYETV
                     ELIQAAGYKELVLDVTGENIKDTYTNAIQVRRTALKEQDRTFGYPSIVFANRLSNSNP
                     MMEVALSSIFTIKYGSIIVIDDISYAKALPLFALRQNIYTDPQRPMRVEPKIYPINNP
                     DENSPVLVTVDFALTYFIVAGDIERSKVPVWLVIPDAGGYSVLTSWAAGKFGGNSISA
                     FIKESKVEEVTNCKDLIIPGKVAVLKGDIEDNLPGWNVVIGPEESMELPKFLKGYQEK
                     ACQTN"
     gene            complement(13326..14270)
                     /locus_tag="KR257_001614"
     CDS             complement(13326..14270)
                     /locus_tag="KR257_001614"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003432254.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="acetyl-CoA decarbonylase/synthase complex
                     subunit delta"
                     /protein_id="HBH0030319.1"
                     /translation="MAFKMSTQKYSGKISEVEVGIGEKAIKLGGENVLPFYSFDGEVG
                     NSPKIGIQISDVYPESWTDSYKELYKDVANCPVEWAKYVEANTQADFICLKFDGSDPN
                     GLDKSVDECADVAKAVIEAIKLPLVVAGSGNHEKDGKLFEKLAQTLDGHNCLFMSAVE
                     DNYKGVGASAGMAYAHKVGAESSVDINLAKQLNVLLTQLGVKGENIVMNVGCSAVGYG
                     YEYVASTMDRIRLAAFGQNDKTLQMPIITPVAFEVGHVKEAIAPIEDEPDWGCPEERT
                     IAMEVSTAASVLVGGSNAVILRHPKSIETIKELVNALA"
     gene            complement(14290..15060)
                     /locus_tag="KR257_001615"
     CDS             complement(14290..15060)
                     /locus_tag="KR257_001615"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418348.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AAA family ATPase"
                     /protein_id="HBH0030320.1"
                     /translation="MGYNIAVAGKGGTGKTSLTGLLIDYLVKDKKGPVLVVDADANAN
                     INEVLGIEVEATIGEIREEVNQREKLGNAFPGGMTKAQYLQFRLNSIIEEGEGYDLLV
                     MGRSEGEGCYCFVNGILREQVNKISGHYKYLVMDNEAGMEHLSRKVTRHVDTLLLVSD
                     CSRRSIQAVARIRDLAEELKLSVGRILLIVNKVPNGVMNDGVKEEIEKHNLELIGVVP
                     MDELIYEYDSTGIPLVNLPEDSKSKVAMKEIFAKLELK"
     gene            complement(15116..16501)
                     /gene="lpdA"
                     /locus_tag="KR257_001616"
     CDS             complement(15116..16501)
                     /gene="lpdA"
                     /locus_tag="KR257_001616"
                     /EC_number="1.8.1.4"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003432255.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dihydrolipoyl dehydrogenase"
                     /protein_id="HBH0030321.1"
                     /translation="MKIVVVGGGPGGYVAAIKASMLGADVTVVEKRRVGGTCLNAGCI
                     PTKALLASSGVLNTVKEAKDFGIEIDGTVKPNFTAIMERKNKVVNQLISGIEFLFEKR
                     GVNLVNGFGKLIDKNTIEVTKDDGTVETIKADKIILANGSVPVVPRMFPYDGKVVITS
                     DEVLGLEEIPESMLIVGGGVIGCEIGQFFRALGTEVTIVEMVDQILLNEDKDVAKQLL
                     RQFKKDKIKVITGIGVQTCEVVDGKAVATLSNGKVIEAQYALVCVGRRPNLDNSGVED
                     IGIEMERGKVVVNEHLETNVEGIYAIGDIIDTPFLAHVASKEGIVAVENALGKTKVVD
                     YRAIPRCVYTEPEVAGVGKTEKQLEAEGVEYNVGQFDFRGLGKAQAIGHFQGFVKVIA
                     DKETDKIIGAAVVGPHATDLLTELSLAVHLGLTVEQVGDAIHPHPSLSEGLMEALHDV
                     HGECVHSVPKL"
     gene            complement(16545..17426)
                     /locus_tag="KR257_001617"
     CDS             complement(16545..17426)
                     /locus_tag="KR257_001617"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729430.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="methylenetetrahydrofolate reductase"
                     /protein_id="HBH0030322.1"
                     /translation="MSLLRETLESGKFAVTTEMAPPKGTDLSHLIECAKPLVGRVHAA
                     NVTDFQSAVMRATSLATCKLLKDAGLEPVIQITGRDRNRIAIQGEMLSAGVFGINNLL
                     ALTGDHTSVGDHPQAKGVFDLDSVGILQTAETLMAGTDMAGNKLKGSPDFYLGASVTP
                     EYSPIEVQLLKMKKKIKAGAKFFQTQALYDINTMRKFRELTRDMDCKVLAGIVPLKSP
                     GMAKFMTANVPGIFVPDEQIERLRAAGKENWVSEGIKMAGELIKQLKEEDLCDGVHIM
                     AIGAEENIPAILDAAGL"
     gene            complement(17462..18136)
                     /locus_tag="KR257_001618"
     CDS             complement(17462..18136)
                     /locus_tag="KR257_001618"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003432263.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="methylenetetrahydrofolate reductase C-terminal
                     domain-containing protein"
                     /protein_id="HBH0030323.1"
                     /translation="MIISENKPLEEVLGYLKDFDKLVLVGCNQCAATCKSGGEEEVLK
                     MKETLEGEGKKILGYVMLDPACNLLKSKKDLKALKEETKEADAVLSLACGDGTQTIVK
                     NLKDKPVYPANNTLFIGEVQRVGEYEEACKACGDCELGWTGGICPVTMCAKGLMNGAC
                     GGAKNGKCEVNSENDCAWIKIYERLEAIGQLDNLAEIRPPKDYSKQNNPRSLSAKKKK
                     EAAANS"
     gene            complement(18173..19045)
                     /locus_tag="KR257_001619"
     CDS             complement(18173..19045)
                     /locus_tag="KR257_001619"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003432264.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional 5,10-methylene-tetrahydrofolate
                     dehydrogenase/5,10-methylene-tetrahydrofolate
                     cyclohydrolase"
                     /protein_id="HBH0030324.1"
                     /translation="MEGMSTKGQIIKGKPVADKISEELIKEVDLLIKEGINPKLTIVR
                     VGARSDDLSYERGALKRCQNIGITTEVLELAEDITQEEYIDVLKRVNDDKNVNGILCF
                     RPLPKHLNEEVIKYVIAPEKDVDCFSPINSAKVMEGDKSGFPPCTPTAVVEILKHYNV
                     DLKGSKVTVLGRSMVVGKPVSMLLLSEHATVTICHSKTKNLSGVAAEADVLIAAIGRA
                     KMVDESFVKDGAVVIDVGINVDEEGNLCGDVDTNAVLDKVSMITPVPAGVGSVTTSIL
                     AKHVVKACKLQNNK"
     gene            complement(19137..19769)
                     /locus_tag="KR257_001620"
     CDS             complement(19137..19769)
                     /locus_tag="KR257_001620"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418328.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cyclodeaminase/cyclohydrolase family protein"
                     /protein_id="HBH0030325.1"
                     /translation="MKIADKTCVDFVEVLSSKEAVPGGGGAAALVGAIGMALGSMVCN
                     LTIGKKKYAEYEESVKEILSKAGKLEKDLLKMIDDDAECFLPLSKAYGLPKETEEEKR
                     IKAETMEKALKVACEVPLNIVRVCYEAIKLHEDLVDKGSRLAISDVGVGVQCLRAAIL
                     GGQLNVVININSIQDKEYVNKVKTEVDKLVEDGVKICDEVYAKVEKALGK"
     gene            complement(19874..21550)
                     /locus_tag="KR257_001621"
     CDS             complement(19874..21550)
                     /locus_tag="KR257_001621"
                     /EC_number="6.3.4.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014355320.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="formate--tetrahydrofolate ligase"
                     /protein_id="HBH0030326.1"
                     /translation="MGFKSDIEIAQEAKPQDIREVAKKLGLGEDDVELYGKYKAKVDY
                     NLLKRETGKKAKLILTTAINPTPAGEGKTTTTIGVADAFAKLDKNVLVALREPSLGPV
                     FGVKGGAAGGGYAQVVPMEDINLHFTGDFHAIGAANNLLAAMLDNHIHQGNALRIDPK
                     KITWRRCVDMNDRQLRNIVDGMGKKGDGAVRQDGFDITVASEIMAAFCLASDISDLKE
                     RLGNIIVGYSYEGEPVTARQLKANGAMAALLKDALKPNLVQTLEGTPSFVHGGPFANI
                     AHGCNSVIATRMAMHFADYVITEAGFGADLGAEKFLDIKCRMANLKPDAVIIVATVRA
                     LKYNGGVAKADLNNENLEALEKGLPNLLKHVENITQVYGLPAVVAINRFPLDTEAELK
                     LVEDKCKELGVNVALSEVWAKGGEGGIAVAKEVLRLLDEEENNFRFCYEDDLSIKDKI
                     NAIATKIYGADGVDYTPEADKEIANLEKLGFTKVPVCMAKTQYSLTDDQTKLGRPTGF
                     RITVRQATISAGAGFIVALTGEIMKMPGLPKVPAAEKIDVDENGVIAGLF"
     gene            complement(21799..22578)
                     /locus_tag="KR257_001622"
     CDS             complement(21799..22578)
                     /locus_tag="KR257_001622"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888532.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AAA family ATPase"
                     /protein_id="HBH0030327.1"
                     /translation="MKIAITGKGGVGKTTFSSMLSRMFAEDGYRVVAVDADPDANLAL
                     ALGFPKEVYESIVPISEMKKLVSDRTAASVGSFGKMFKMNPKVDDIPENFCKEYNGVR
                     LLTLGTVDSGGTGCVCPEHVLLKRLCSHLILQNKDVVVMDMEAGIEHLGRGTAQGVDA
                     FIVVVEPGERSLQTYRKVKKLGHDIGVNKVFVVGNKIRNKEDEEFIIQNLEDGESLGF
                     IYYNQDVIDSDRANQSPYDSSETTKEQIKAIKDKLMSLKDK"
     gene            complement(22888..24807)
                     /gene="cooS"
                     /locus_tag="KR257_001623"
     CDS             complement(22888..24807)
                     /gene="cooS"
                     /locus_tag="KR257_001623"
                     /EC_number="1.2.7.4"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860935.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="anaerobic carbon-monoxide dehydrogenase
                     catalytic subunit"
                     /protein_id="HBH0030328.1"
                     /translation="MDEKMLTIDLNSQKMIAKAREEGVETMYDRKEGFKAQCGFGLQG
                     VCCRICGMGPCRISPKTPRGLCGADEHTIVGRNFARMVAGGTAAHSDHARDIAHTLAL
                     ADPNGNYKIRDEAKLITLAKEWDVETEGRDIYDVAHEVAEIALMEFGKPFGTLRFIKN
                     APEPRQKIWKEYAIEPRAIDREIATIMHSTHIGCTGDIDSLIHMSLRTSMADGWGGSM
                     IGTRLSDILFGTPVPRRTEANLAVLEENKVNIILHGHEPALSEMIVLASEEPDLVALA
                     KEVGADGINLAGMCCTGNEITMRHGVKIAGDFHQQELAIITGAVEAVIVDVQCIFPAL
                     ARVADCYHTKFVTTSPKAKITGSTYIEFREEQALDDAKAIVKEAILNFKNRDKSKVLI
                     PELKSGATVGYSVEAVVNQLDRVVNSHIDPAGTVKPLTDCLKAGVLRGAAGVVGCNNA
                     KGVSNEAHVTIMKELIKNDIIVVTTGCGASAAAKFGLMESDAAEKYAGKGLATVCKLV
                     GIPPVLHMGSCVDISRILDLVGAAANYLDMDMCDLPVVGIAPEWMSEKAVAIGCYVVA
                     SGIDTYLGIMPPIAGSSRAVDILTSELKDKVGATFTVNTNPKELAATIIEDIEKKRVH
                     FEALVEEKMAEKAEA"
     gene            complement(25414..26325)
                     /locus_tag="KR257_001624"
     CDS             complement(25414..26325)
                     /locus_tag="KR257_001624"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436909.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional enoyl-CoA hydratase/phosphate
                     acetyltransferase"
                     /protein_id="HBH0030329.1"
                     /translation="MIKKLDDILEQLKGGEKIVLSVAAAHDKEVLMAIKDAVERNIIT
                     PILVGNEGKIREISKEIGFDLSGIKIVDKDDIKECAEIAVKLVSSKEADFVMKGLLDT
                     SVILKEVLNKDYGLRTDSLLSHVMVYELEKYHKLLITTDGGMNIAPDYEQKAKILKNS
                     IKAAKALGMETVKVACLAAKEKVNPKMQATVDADMLAKACKEGEFGENVIVEGPLAFD
                     LAVSKEASEIKGFKSEVSGDVDIILVPTIEVGNGIGKAFTYMADSKSAGIIMGAKAPI
                     VLVSRADSHESKLYSIAYGAIVAKNMK"
     gene            complement(26441..27019)
                     /locus_tag="KR257_001625"
     CDS             complement(26441..27019)
                     /locus_tag="KR257_001625"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902116.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sugar O-acetyltransferase"
                     /protein_id="HBH0030330.1"
                     /translation="MNINEFLTHINQRKPVSSKSEIHEFMVKLSNEAMKITSKLNSSY
                     HEPEEVRSLFSELIGKKVDESFFMFPPFYTDCGKNITIGKNVFINSSCHFQDQGGIEI
                     GDNTQIGHNVVLATLNHGIAPEKRGTTYPSPITIGKNVWIGANVTVVPGVTIGDNAII
                     AAGAVVTKNVAENTIVGGVPAKLLRAIDEIPE"
     gene            27245..28168
                     /locus_tag="KR257_001626"
     CDS             27245..28168
                     /locus_tag="KR257_001626"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895771.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LysR family transcriptional regulator"
                     /protein_id="HBH0030331.1"
                     /translation="MEIRVLRYFLAIAREESISGAATFLHITQPTLSRQIMELEEELG
                     VKLLVRGNRKITLTNEGRLLHKRAEEIISLVDKVELEFDNPNEIISGDIYIGSGETEA
                     MRLIARTAHHFHQKYPNVRYHLFSGNADDVTEKLDKGLLDFGILIEPANIQKYDYAQI
                     PATDVWGLLMRKDSALASQSTINPKDLCNIPLIISRQTLVDKAISKWLQGSNEKLNII
                     ATYNLVYNASLLVEEGLGYALCLDRLVNTTENSNLCFRPLSPPLEAKLNIIWKKHQIF
                     SKAAEKFLLQIQKDFSSIMLDTSKLDTPKEK"
     gene            complement(28340..29482)
                     /locus_tag="KR257_001627"
     CDS             complement(28340..29482)
                     /locus_tag="KR257_001627"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418311.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tetratricopeptide repeat protein"
                     /protein_id="HBH0030332.1"
                     /translation="MDFKIEKYLLKKAEELAFITIKHGGEFKLKSYEVPKGGLDVPIK
                     NEVLVKGIKEKTAQDKLNSMSIADAMIYIIGIDSKFKNNAEYEKFLNALSKDIDLDLK
                     SYMGYMSRKYFEIGEHTDSLIYIKAFITMYPDDLDAMYNYAIVCQEIAKQYQKDMDDK
                     AMNAFLLEAMAKLEKVIDVDENFALGYYHLGYHYYNQGQYLKTKLTWEEALRLGLDAD
                     LVAEVQENLGKMDFKVQYEEGYTLVFQGKFKEGLEKLLPLEEEHMDWWNLLFMIALGY
                     KGMGEIEQAKMYLEKILIIKPNQVDTIVELGLCEAYKNNLDKAIEYFEQAAKIKEDPE
                     ILCNLGMAYLNNGDIDDATYYIERAYELNPQDEITIACLRELGINK"
     gene            complement(29500..31254)
                     /locus_tag="KR257_001628"
     CDS             complement(29500..31254)
                     /locus_tag="KR257_001628"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860933.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="B12-binding domain-containing radical SAM
                     protein"
                     /protein_id="HBH0030333.1"
                     /translation="MKILLTTLNSKFIHTNLAIRYLKEFVRDLIEVNMKEYTINNDLD
                     YILKDIYKNEYDIILFSTYIWNVGDIVKLCDNLKKIRPNTKIALGGPEVSYDSYEAMK
                     KYDFVDYILYGEGELIFRDLVLHLQGKMEINDVNGLVYRQGNEIIVNKPMELLQDLDE
                     IPSPYENLNPKEYENRIVYYESSRGCPFNCQYCLSSTIPGLRYFSLDRIKSDLKALID
                     ARVSQIKFIDRTFNANRKVAMEIMDFLMKNDNGYTTYHFEVTAYLIDDKMLEFLADCK
                     EGLFQFEIGVQSTNEKTLDAVGRRDDFKKLSHVVQTVASYRNIHQHLDLIAGLPYEDY
                     KSFENSFNDVFNLGIEHLQLGFLKMIKGTGMRKVADEHGFKYKDYAPYEFLYNNYISY
                     EETLKLKDIEDILERYYNSKNFVLSMRYIIGRFYKKSPFKFFEVFAKYFDENGYFDLA
                     QGKNQLYKILMDFYNEKINIDNDVFNDILKYDYISLGKTSNIPQFFNKLDVDDFKNRC
                     HVFLQDNDNLSTYLPSFVDKPAKHIIKYVHFEPFRFNVVDLKNDINTEIREVENVVLF
                     EYDDKKIFEKSKTHKVEI"
     gene            31390..31596
                     /locus_tag="KR257_001629"
     CDS             31390..31596
                     /locus_tag="KR257_001629"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418305.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0030334.1"
                     /translation="MELIEKVSINSLSKRDLLLIIKSLEYTNENTQISDFIDLRNNIV
                     KELCFLTDTKEKDFLDYLEKNSTL"
     gene            complement(31601..32524)
                     /locus_tag="KR257_001630"
     CDS             complement(31601..32524)
                     /locus_tag="KR257_001630"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860932.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0030335.1"
                     /translation="MNDELLKKVYTSSFSSASRALKDLTIINTKSLIDDKTQRCVYID
                     ENRLRDELIYYRFYGEKIGNINFLNILLPLILSNTNIQKSEDEVIKLIKKYVIYFKKE
                     ELLFDYLLGSVVYNSIMHNLINNSKIEYVELLQSIKDKIIGFSIELDKSDVVKFQMAR
                     IKAIQLIDKYIDLKSEDYDEESILLNVLNVLYDVYMEDRTVENEGINSIKKSILSILG
                     EDSKLNEDNIDFIFSMSEYVVKLRKYKIGVKAYNKSIDPRSLIRLEEGNTIVDPIFNQ
                     ITVMSKTFNDNILSIKINSKSGIYILKFKKV"
     gene            complement(32778..34478)
                     /locus_tag="KR257_001631"
     CDS             complement(32778..34478)
                     /locus_tag="KR257_001631"
                     /EC_number="6.1.1.19"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003432277.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="arginine--tRNA ligase"
                     /protein_id="HBH0030336.1"
                     /translation="MQDFKVAISNCLKEKIEDLSKEEIEALIEVPPNKDMGDYAFPCF
                     KLAKVFRKAPNMIASELAESIEPSGEITKVIQLGGYVNFFVNKSQLAETVIKKVLDEK
                     ENYGHSDFGKDKTVIVEYSSPNIAKPFHIGHIRTTVIGNALYKIYDSQGYKTIRINHL
                     GDYGTQFGKLIVAFKKWGEKEVVESNPIPELLKLYVRFHDEAEQHPEMEDEARAWFNK
                     LENGDEEAQELWQWFRNESLKEFNRVYKLLDIEFDSLAGESFYSDKMNRVIELLEEKN
                     LLKESKGARIVDLEEYKMPPALITKNDGSTLYMTRDLAAAIYRKETYDFDKCIYVVGS
                     QQNLHFQQWFKVIELMGYDWAKDLIHVGFGMVALEEGTMSTRKGRVVFLEDALNQAID
                     KTKEIILAKNPNAKNVDEISKQVGVGAVVFQELSNSRIKDYTFSWERTLSFDGETGPY
                     VQYTHARCCAVLRKAEVEVTSDIDYSLLADEDSAEVLRVIESFNKNILLALKKNEPHI
                     VTRFMLDLAQAFNKFYHDNPILVENLEIRKARLALVLATKQTLENSLKLLGMHAPERM
                     "
     gene            complement(34888..35301)
                     /locus_tag="KR257_001632"
     CDS             complement(34888..35301)
                     /locus_tag="KR257_001632"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860931.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF523 domain-containing protein"
                     /protein_id="HBH0030337.1"
                     /translation="MILVSACLIGINCKYSGDNNDNEKVKEYLKGKEFTLVCPEQLGG
                     LSTPRPPAEIVDGKVITKDNKDVTENFVRGANETLKIANLYVCSEAILKEGSPSCGCN
                     LIYDGSFSGKKIPGKGITARLLEEEGIKVKSEKDL"
     gene            complement(35367..37745)
                     /locus_tag="KR257_001633"
     CDS             complement(35367..37745)
                     /locus_tag="KR257_001633"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860930.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="endonuclease MutS2"
                     /protein_id="HBH0030338.1"
                     /translation="MNEKSLRVLEYNKIIDLLKKKASSSLGLKYIENLVPNTDFVEVK
                     SMLEETSEAQSIIIKRGSVGLEGIHDIEDKVKRAYIGASLDPGSLIMIADTLRVARRL
                     RNSLSSSDEEDFNYPIIQSLSNSLYVYKDIEDQIYNAIISEVEISDNASSTLRDIRRR
                     IAQKNQSIRSKLNSIISSTTYQKYLQDAIISLRGDRFVVPVKSEYRSQVAGIVHDQSS
                     SGATLFIEPMTIVEMNNELRQLKLGEQEEIERILSELSAMVGEVSEDLISNQEILGRL
                     DFAFSKGKLSIQMRGIEPTLNEDKYLNIKNGRHPLLDKKKVVANTIYLGRDFHTLVIT
                     GPNTGGKTVTIKTVGLFALMTQSGLHIPADYGSSMCVYDNVFADIGDEQSIEQSLSTF
                     SSHMTNIVSILQNVTADSLVIFDELGAGTDPVEGAALAIAVLEDINSVGAKCIATTHY
                     SELKNYALTKPGVENAAVEFDIETLSPTYKLLIGVPGKSNAFEISRKLGLSDYVISRA
                     KEYINTENIALEDVLQNVEKNRIKAVEDREEAERLKEEIEKLKVEYDEKLEKLVSQRD
                     KMIEKAKSEAFSIIRQAKEEVDIIIKELRSLEQERASKEKNRKIEELRKELTSSMGSL
                     QPTVKSMIVPKVSNKEIKDLKPGEEVKVITLNQNGSVVSVDKKRKEAVVQIGIMKMTL
                     PFKSLQKTRKDVSTNVTKSTRNIIRSKSGSVKNEVDLRGLNLEEAIMEVEKYLDDAYV
                     AGLESVTVIHGIGTGVLKAGLQDILRRNRHVKSQRGGQYGEGGAGVTIVKLK"
     gene            38064..39515
                     /locus_tag="KR257_001634"
     CDS             38064..39515
                     /locus_tag="KR257_001634"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895759.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aminoacyl-histidine dipeptidase"
                     /protein_id="HBH0030339.1"
                     /translation="MGNVLEGLKPESVFKNFEKISQIPRGSGNEKGISDFLLSFGKNL
                     GLETIQDESLNIIIRKPATKGYENCPGVVLQGHMDMVCEKEKNVEHDFLKDPIKLRID
                     GDMIYATGTTLGADNGIAVAMGMAILEDNTLEHPALEVLVTVNEEDGMNGADALDPSL
                     IKGQYILNMDSEEEGYLLVSCAGGKTCVVSLPVEYKEVKGDKQGLLVEVTGLLGGHSG
                     MEIVLQRANANKAIARVLSVLNVDYELASVDGGTKHNAIPREAKCVIAVNKADVESAK
                     KQINDILTAFKHEFTTSDPGMTYSVAETSVDKVLTKDCKEKVVQMSCLTPHGVQSVSL
                     DIEGLVESSTNFAIIETKESTIEFLTSVRSSVMSIRDEIADRIRLLAQALGANYDLIA
                     QYPAWEFKKGSKLEKICSETYEKLTGKVPTVMALHAGLECGLLLDKLPHAEAISIGPD
                     MFDVHTPNEHVSIPSVANVWDYVIEILKSMNQY"
     gene            complement(39719..42232)
                     /locus_tag="KR257_001635"
     CDS             complement(39719..42232)
                     /locus_tag="KR257_001635"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436881.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transporter substrate-binding domain-containing
                     protein"
                     /protein_id="HBH0030340.1"
                     /translation="MEDCVVNLKKLLLLIIVITSIFTSCIFSFGINAIGNDNRTIRVA
                     YPIQKGLTEIDEQGNYFGYTYEYLLEIAQYTGWNYEFVQVPGEINESITKLMKMLENG
                     EIDIMGGMLYNEPMQKIYNYAGNNYGVANTVLQALYENTDIDNIMSSQDVKKIRIAVI
                     ENSDTRLKELDEYCKMNLMSPELVYCKTNDEQLEALKSGKADVLLNVSMNPIEGVRTV
                     AKFSSKPFYFITPKGSTNLTQKLNSAINNIEQKDPYFSTTLYEKYFTPENNQMFLSDE
                     ETNYIKETEKLKVGVLLNKPPFQNIDKDTGELRGISIDLLNHICDKTGLEFELVPVKS
                     QEDLENMTKKREIDIVAGMIYDYEYSREHNIAMSRPFLSTQYTMMINNKLNENSLDGK
                     RVALAKGINYYGQFEENIVWYDNLEECIEAVNKGYADYTYGEGYSMQYYMNQPKYKNV
                     RLVPQTYKAKSICFGIIKKDKQELLNIFNKAIISISSEKMQSIVYQNTTYRQDFSLLY
                     IMQQNPIETIFIVASLLICIIGFMAFGLHTRTSMNEKISLELKKHTQLYEMTSEYFFE
                     YDYKQDKLIISMPEKGIETYYGLDKNDKESENGNIENERDKIRKEYNKKFFDVIKSQE
                     NGTTEMYSIMLDDTFHWIRVTSKIIYNDRKIPMYVIGKICNIDSEKEEKNRLLDKAQR
                     DSLTNIYNAAYIRKLTSQNLLNLSTEKNGALLIIDIDYFKSINDTYGHLLGDKVLIDV
                     AKALDESFAKNDIVGRLGGDEFSVYINDIINKEELINKCNDVYNHIHLIKLPNGESLS
                     ISMGVVIAKPGQEYDELYQIADNALYDSKRQGRNRFKIV"
     gene            complement(42455..43276)
                     /locus_tag="KR257_001636"
     CDS             complement(42455..43276)
                     /locus_tag="KR257_001636"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436880.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nitroreductase family protein"
                     /protein_id="HBH0030341.1"
                     /translation="MIDINLEKCVGCGMCESDCLVNAIKVKDDKAKVKNILCINCGHC
                     MAICPTDAIEMQGFDKNEVIEYNRESFELEPEKLLNFIKFRRSIRQYKDIEVEEEKIK
                     NIVEAGRYTPTGGNRQPIRYILVKEKLKEVKELAIQGLYNLALDTDDNDPVRSIYKNT
                     FKKMYKRYKENGNDSLFYDAPLLMVVVGDMSLGGSAYVDGGLAASNMELMAYSQGLGI
                     CYNGFFVMASNVEPKIKELLGMSENEAVITSFILGYPDVKYKRTVNRNTAKFEVR"
     gene            complement(43794..44270)
                     /locus_tag="KR257_001637"
     CDS             complement(43794..44270)
                     /locus_tag="KR257_001637"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888511.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="8-oxo-dGTP diphosphatase"
                     /protein_id="HBH0030342.1"
                     /translation="MKLTTICYIEKDDKTLMLYRNKKKDDIHEGKYVGVGGKFEQGET
                     PEECVIREVKEETGLTLKSLSYKGLITFPKFKDEEDWYMFLYFSDEFEGELSEKDLND
                     CKEGNLIWVDNDKIFDLNMWEGDRLFLNWAKTGNIFSAKIVYDNGKLKDYNVSFLD"
     gene            complement(44305..44883)
                     /locus_tag="KR257_001638"
     CDS             complement(44305..44883)
                     /locus_tag="KR257_001638"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418276.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HD domain-containing protein"
                     /protein_id="HBH0030343.1"
                     /translation="MREEALEILFKYLETDRMRKHCYAVEAVMRELAKRLEPEKEEEW
                     AVAGLLHDLDSDIVGRKPGEICEGHATTTVELLKKENFGNEEMYRAILGHHDGMGVTR
                     TSLMEKAIYAADPITGFITAIALVYPDKKLTSVKTKSVIKRMKETRFASNVNRDAMRS
                     IEDIGIPFDEFAELSLNAMKNISDVLESAENN"
     gene            complement(44987..47587)
                     /locus_tag="KR257_001639"
     CDS             complement(44987..47587)
                     /locus_tag="KR257_001639"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895753.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="U32 family peptidase"
                     /protein_id="HBH0030344.1"
                     /translation="MKKIELLAPVGSFDSLKAAVQNGANAVYLGGKDFSARASANNFD
                     RNELIEAVKYSHIRGVQVFVTVNTLIKQYEIEDFVEYVKFLYDIDIDALIVQDIGMAR
                     LIKKLLPDFELHASTQMVAHSLEDVKYLQSVGFDRVVLARELNVDEIKWICENTTVDI
                     EVFVHGALCVCYSGQCLMSSMIGNRSGNRGRCAQPCRQKYELIDINTGEVVKSNGDYL
                     LSPRDLSTIEDLDKIIEAGVLSLKIEGRMKKPEYVATVVSGYREAINEFVDKKKISIS
                     EEIINNLYTIFNRKFTKGYILGEVGKDIMNSNRPNNQGLYIGKVLDYNRKNKRLRVML
                     ENTLKKGDGINLGGGTIGRIIKDGEITTIAHKGDLIELDFVGEAKRNQLIYKTSDSEL
                     MDRVQATFQQDKEFIKTNIRAKVSIKLGKKPELFISDFCGNKSVVEGDKIVEKAIKVA
                     LSKEKIETQIQKLGNTPYKLKEIEIDLDEGVSMPISVLNQMRRDCIELLDEERIKIKD
                     RKFKKNRLKYQPNRVNKQKKLDTAPKIRVKVKNLEQLEAVLNYNVDLIYYEDINTLSK
                     ALQMVSSISIDSNISIDSSISMDLDTSSSLGTPKELMGSNTNNIDTLSNTSKIDTLNK
                     NHSNTAVTDKKLIYSAPRIVRNKEYKQFEILDNIKGINKVQIGNWGSMEYFKKKDLNI
                     DCYLNVFNSESINHFKEEGASTVCLSQELNLNEIKQTLKYTDVEIEAVIYGYAPMMVT
                     EYCPMGVVVRDCKKDKRVAKCKESSYALRDFTDASYRITQDIFCRSTIYNSKVTCMLD
                     NLYELEEIGIDVFRIDFTVEDSEMVKKVIEAHIEVLSNNYKLGKKATDLYKKLDEIGT
                     VAGHYYKGVE"
BASE COUNT        14664 a         9152 c         5369 g        18687 t
ORIGIN      
        1 acaataaatt taaaaaggag aattaaatat gaaaaaaaga ttaataataa tgatattgtc
       61 tgttgtctta gtactatcaa gtatacttac gatatttgca tattcaaata ttaaatataa
      121 taataataaa ttgatatatt ctaatatgat agataaaaaa actcaaaata gtgtaaagga
      181 aatcctaaaa gaaaataaaa ttaatgaaaa agacatagat acatttatta aagcagtcaa
      241 caattataat aaattgcaag ttaaaatact tcaaaataat ataaatatat ctaaatctgg
      301 atattcttca atcaatgcaa aacaagttcc atataaccta gaaaaattgc aagataattg
      361 ggtgaaaaaa ttccctgatt atatggatgt aaattgtaga ataactgctt ttagactttt
      421 taaagatttt ataaattcaa ataagaaatt tactggagac tctattgatt tgaatgtcga
      481 cttggacact ataatgaata ataaagatgc taaatttagc atcaaagatg tagaaaaatt
      541 tatcaacttc ttttctgcaa taccagctaa agatacagat gatacaatca aaatttcaga
      601 acaaataaaa aatgaatgga aaaaaagaaa aatatctttt aaaaataata aaaatatatc
      661 tattataaat ggatttcttc gttatccaga aactaaaaac gtatttatag gtcatacagg
      721 catatgtatt aaaactaaaa atggcattct atttttagaa aaatacggtg ttacatcacc
      781 ttatcaagtt actaaattta aaaataaaga agatgtaaaa aattatatgt ttaatagatt
      841 gaagatgtca gaaggtgaaa ttgaattacc tgaccctata ataatggaaa acgataaact
      901 tatgaaataa taactttaaa cgcaaaataa tatttataat tactaagtca atataataga
      961 gaaggtctat agatttgtgt aaatacaagc ttatctacaa tcttatataa gaatatttat
     1021 ataaataaga tagattaatt ctaagtccta ttattctatt gaattttatt attattttat
     1081 ttagattcta ttgttatttt acttagaact tattattatt ttgtttaagt tctattacta
     1141 ttttcaatca tataaattta caaaagactg tacataaatt tattttatac aaacttatct
     1201 acagtctttt gtgtgaatat atctaaacaa tatcgtattt atttatttcc tctgcacagt
     1261 gagaatcaga acctaaaatt aatggaatat cgtatttttt taccaactct aataagtatc
     1321 catctatata aggctctttg cagtactctt ttctatttcc agaaacatta taatcaagtt
     1381 cataaccttt ttctttaatt aactttatta actcttcaag aattgtattt cctttataat
     1441 cgtatggaaa tacctgatta aactttctaa ctaaatttaa atgacctatt ctttttggtt
     1501 tatgtatacc taaatctgaa tttacagctt ttatcaatgt ttcataatac ttattataaa
     1561 cagcttcaat acttcctaat ttgtcgatta aattttgaaa ctcctctaca ctgtaatcta
     1621 cacaataata atcatcatca atcttaatta tatgtactga taaaagagaa tcctctaatt
     1681 cctttccata tttatttaaa ttctccttta tcccttcttc gtatccttct ataaaatcca
     1741 cttccgaccc aacatttatc ttgattttac cctcatactt ttctttcaac ttcttgacat
     1801 cattaaaata ctttggtaaa tcttcaatac tcatacaact atcattttca ggagcagggt
     1861 ctctaaatcc atttgcatac ggaaaatgtt ctgtaaatgt catttctgtt attccaacat
     1921 ccattgctct ttgtacatat ttttcaaaat catccttact tccatgagga caataaggtg
     1981 aatgtatatg accatctttc ataaataatt cactcctttt ttaaagaaaa aatctaatat
     2041 aaatgcataa atcttttaac ttcaaaataa tatttttaat catgctaatt tttattatat
     2101 ctaatattag agtaatttta aactgccttt taagtatctt atcattagta ctattttcaa
     2161 cttaacatta atattatttt ttaacttaac attaatacta tctttaaata gtaatactca
     2221 atatataatt acttaacata aaataactca aattgcttga tgaggctttt gcagtattta
     2281 aagaatatat aattatttaa cattaaataa tccaatcttg taataaaatt tactcattaa
     2341 agtatattac agaaaatacc tcaaaataaa ctttttagtt catgatatac tcttttttgc
     2401 atgaaattag atatattttt atcatttcaa caatgaaagg gaggcttata tccatcttta
     2461 gacaacccct tagataaaat ttttaataat taaacatcac aaaatataaa aatcgcttat
     2521 atcaaacgta taagcgatta attatattta catatgtttt ttagcctcta acaacatttt
     2581 attagcttct tccatatact ctatagcctt ttcaatactc tttgctgttt cttcttttcc
     2641 aatagctcta gccttttcaa cccactctct aaatccttct tcatgagttt cattgtgatt
     2701 tatccaatgt actaaaagta tttttaaagt tttttcatcc ttagactctg atgattcctc
     2761 atgactatgt tcgtggtcgt ggtcgtgagc atggtcatgt ggatgttcat gacatatatc
     2821 tccatgagta tgttcgtggc agtggtcatg gtcatgatgt ccatgatgat atcttacaat
     2881 ctctttatca aaaatcatta gttattcccc ctgttatttt atattaaact ctttttttat
     2941 aaggtttaca gaatctttta caagtagtgc taatggttta ccttctaatc caactaactc
     3001 cacattttct ggcataatag gtaaaagtat cttaagtgcc tcactgtctg caatagcttc
     3061 acttatatta caagtaactt ctcccatcat agaattaggt attattacag aaataggtgc
     3121 aactattata tttgcttttt tagctgatac tactatagca ttttcccctg tagctccttt
     3181 attagcatga gctttcatca tagaactagt tgctatagaa ttagtcccta gtgcataaat
     3241 ttctacatat gtaggtaact cttctctcaa agaagaaact atctgggctc caatacctcc
     3301 acccattcca tctatcactg ctattatcat atgaaattcc cctattaatt aattttcttg
     3361 tattattatc ttatggtcca tcaatcttat ttctttaatt atcccatcta ttatcttttg
     3421 ctctcctaat aaatccgtta aataaatctt tccatcacaa gggtctatat taaccacatt
     3481 ttccataacc ttttctaact cattattact tttacaaatg aaagctgatg attcacacat
     3541 ataaatctcc tcctaatatg atttttatta aaaatcaaaa aaagattccc ttaggtattt
     3601 caatacacca aagaaacctt catgatttca gtttttgtat attattatac cttaagtata
     3661 tcactttaat ttatgtaaag tcaattaaag ttaacgcttt ttattatact cttcattctt
     3721 gtatttttca tatagttctt taactaattg cttctcataa tcagtcaaat cgccctccac
     3781 aaactcaaca ttaaattgtt cagctaatcc ctttactatg tttttctgta gaatatctat
     3841 gtctattttt ctgccaattt cattttctat tccacttgct tttttagctg taaatttcat
     3901 agctctttct ttcaattctg gtgtcttagt ttttattaat ttaaacaatt tttctacatc
     3961 aaaatccagt attattgaac catgttgtaa taaaacacca tcttttctgc tttgagcact
     4021 tccaattacc ttcttattat taatagtaac ttcatatgat gcatgtgcat taaaacatgc
     4081 agctgataaa ttttccctac ttattctctc gcctctattt aaattatctg tttctatacc
     4141 acttagattc aaccctttaa ctagaccttc acttatatat ctataagata ggttgatgct
     4201 cttatcgatt aaaggattat cttctcctat aattatacta taagttagct cattatcatg
     4261 taatacagct cttccacctg taattcttct agtatagtct atattcatac atctacactt
     4321 atctaaatct atctcatctt ccaatttctg aaaatatcct atactcaaac aagctggttc
     4381 ccatgtataa aatctaagag ttggcttatt atgtcccttc ttatatgcag taaatatagc
     4441 ttcgtcaatt gccatattca ttgctccttc atatgattta ttatgtataa ctctccactg
     4501 attcatgatt attacgcccc catttttagt ataaatatat cctagaaatc ctctatagat
     4561 ttatttctct tattgctaaa tctatctcac tttgatttaa aggtcttgaa tagttgtata
     4621 tagtacttcc tggtctttca ttatagtatg gtctattaca atccttacaa cctcttattt
     4681 caaaaggata gcctttgttt atgtctttta aaatatcatt gtcaagcttt atactattta
     4741 agtatccatt tttaaactta aaatactctt ttggataacc tttatttatc atataagaca
     4801 ttaactgtac ccttctataa ctttctatgc ttggttgatt tatcttttcc attttagttc
     4861 ctctaactgg agtaaatgca aataaactaa tcgttacatc attttccttt aaataagtat
     4921 ataaattgta tatatcttca tgactttcac ccataccaac tattatatgt gtacttattt
     4981 tattgggata tgattttgac atttcagtta taaattttaa cttttcatca tagttatttc
     5041 cttttatttt ttcatatagt tctttatttg ctgcatctat tgctattcct attttatcaa
     5101 ctcctactga aaaaaacttc tttatctgtt catcattttc taattttgca gatagtgaaa
     5161 ttggcatgtc tatcttacca cttatatagt ttataaagtc taaaacagag ttatgtgctt
     5221 cttcacttgc cattgattga atacatattc tctttatatt ttttccttta taagctttta
     5281 aagcatctaa tatttcttct tttgaaaact ctggccaaat tactcttgat aatttatctt
     5341 ttctagtact actttctatt gattgagaac aaaaactgca tttatttatg catttttctc
     5401 caatcattat atatgctgtg gtaggaggta tatcgctttt tttgtttaat atcccaagtt
     5461 ctattgctgt cccaactgat agtctaatca taaaacgcaa cactccttac actcatttat
     5521 tgtcatattc atttctatag ccttattctt tgcagacctt gatggtaata ctattctatt
     5581 gactccacac attatagata attggtctag ctcttttcta tacactcctc ttggtctcat
     5641 acaacctaga ttaatttcag tatctggtaa attaattcta gcttcacata aaatatctgc
     5701 taccccttct aactcaggag gttctacatt ttcatactca gtcccttttg ttggaataag
     5761 gactataaat gtaagcttat taggaggatt tttttgtagg tattctataa tttcatattc
     5821 accctttatt tgtcctcctt ttaaaccaat acatatatgt ggtgctactt ctgtatgttc
     5881 ttgtattgta ttatagactt caatataatc ttctttactc tttttcatct tataaacttc
     5941 tcttattgtc tcatcatcaa acactaaatc aaaagaaact atatctaaat acttacacaa
     6001 ctctacaatg ctatctttat ccataagacc taaatgagca ttcaatctat atccttgctc
     6061 ttttaagttt ttaatggtat taatatgagt atttataggg acatctccct cataactaca
     6121 accgccactc aatagaaagc tagttatatt ccttgattgt actttttcct catattcttc
     6181 tattggcacc atattgttta agtagtgacc gttgcaatgg gcacatttca aactacattg
     6241 attgcttgta gtactaagag ctagtgtctg gttaggataa gcaaactcta ttttatttcc
     6301 aaaattcttt aatttaatat caaatgctat ttccattttt tcagatagat tcttattcat
     6361 agtttattcc ttcttaagta cattttactc ttctagtaat ttctttgctg ttgggaactg
     6421 ctctatattc gtatgtggta agaaacatgc agaaataaat tcatccatat aacttggata
     6481 tacactaagt tcaacataag ttatttgatt acctatttct tcaagtttat tttttgcatc
     6541 tttacttata agagctaagt aagaaccaac aagtgaacta ttccctatat aagtaaattt
     6601 ttctctatca atatcaggaa gtaaccctat aattattgag ttttctatgt ctaggttgtt
     6661 tcctatacca cctgctatat aaaccctatc taatatacta aaatccatac ctaaactatc
     6721 tacaagagtg tatgcgcctg aatatatagc tcctttagct ctgatgaaat tatctatatc
     6781 aacttcattg actactatat cattttctaa atcaaattct tctttaaatg ctaatacata
     6841 ctctcctatc tcatgctcat taaatctaac tctcttatta tctaaatccc tgtatatttt
     6901 acctcttcta tctattaccc ctttagtaat catttgacag attaaatcaa ttataccaga
     6961 accacatata ccaactggtg cacattcatc aataatcttt aatgttggct ctaaagtttc
     7021 tttatcaata attactttct ctattgctcc tgctgatgct ctcattccac agcttatccc
     7081 tccaccttca aaagcaggtc ctgctgaaca tgcacagctc atcatataat ctttatttcc
     7141 aaatacaatc tctccattag ttcctaaatc tataaataaa acattttctt cacttgacca
     7201 tatccctgct gataatacac ctgctgttat atctcctcct acataacttg caacagatgg
     7261 agctaagtac acatatgcac tgtcatttac aaaaagacca acattttcac ccataagttt
     7321 tggagatttt aaaaatggtg gtatgtaagg ttcttgtctt aagaagtctg tatacacacc
     7381 caagaataaa cttgtcatag ttgtattccc agcagccact aatgtaacta catcttcctt
     7441 atctattcca tttctttcat atattgtttt taatagtgga tttatagttt cctcaactat
     7501 agctttatga agtgtctcta atccattttt cttagttgaa tatataattc tatttataac
     7561 atctgctcca tattttatct gtgcatttcc agaagatgct ttatctacta cctcttttga
     7621 gtataggtct actaaacaaa caactactga agttgtacca atatctattg caactccgta
     7681 taaggaattt tctttatttc cttgttctat atttatgatt gtaagtttct tttgtttttg
     7741 aacatatgtt attgtaacct taaaatcact ctttctaaat acagttggca tttttctaag
     7801 tatatccaat ctaaaatcta tttcattata tcctaggtta tttctaacat atctttccaa
     7861 tctatctaca tcacttatat tatcatctaa atttggttct tccatttcta tgtatttctt
     7921 ttttatattt gttttaaatt gaaggttatg ttcttcaatt atttttttag ctctttcaaa
     7981 aatttcccta tcctcttttt tattactacc ttctatcttc ataccatgca tagaagatga
     8041 tactttagaa ggaacttcaa tttctatatc tgatattacc tttgtacaac aagctagtat
     8101 ataaccttgc tcccactcat catctgttat atgtcttgtt ttttctgtat caacttttcc
     8161 attcaataat tttactttac acttcccaca agacacgttt ccattacaag gagcatctat
     8221 gaatatatct gcatttcttg caacctctag taatatatcc ccctcattac aataaacctc
     8281 tttattgttt ggtgtaaaac ttacttttat catgttatcc ctcccaattt gttctatata
     8341 tgataaaagg aaagtatagc taaatttgcg tgcactcaaa ttttactata ctttccccaa
     8401 ttataataat atcttaatct ttaattattc taatccagcc tcgtattctt tatcacttaa
     8461 taacgtatca agttcagcca catcagctag ttttactttt aatatccagt tttcatatgg
     8521 gtcttcattt atacattctg gctcatcttc taatttttca ttaacttcca atacctcacc
     8581 attaacagga gatattaaat cagaagctac tttagaagac tcaactactc caaaatctac
     8641 tcccttagtt acagtatctt ctacttctgg tgtttcaaca aacaatattt ctcctaattg
     8701 atcttgagca tagtctgtta tacctatata tacaacatct ccatcaatta cttttaccca
     8761 ctcatgatct ttagagtatt ttaattctgg taataatttc atttcgatag acccccaata
     8821 ttatattatt gattaaatta cttaaatcat attaatatta tatcatatta ttttaaattt
     8881 tccatcaatt acattacact ttccatagct aatgctggat gacctttttc ttctaagaaa
     8941 gctaatactc cttcagaatc gtcagctata gtttcatcac aaaccatatc acagaagttt
     9001 tctattccag tcatttcttt aactgtagca tttaatttat cagctacata atcttttaat
     9061 tcttttggca tccaaactat tctttctggt ccaccttctg cataagcgaa ttttttagaa
     9121 gatatgaaat gtcttccgtg tcccataaat cctggagttt gaactcctcc acctgtcata
     9181 gaagcaagtt ctccgaaagt cataccaact ggagtaacac ttgcaaattc tctgttaact
     9241 acaacaaatc catttgcttc tggcattata ccacagatac attcgaagca tccacaagaa
     9301 gtcattgggt cttctagtat agagtataat gtaacagatt caactgcacc ttgagatatt
     9361 tggtttacag tttcatttac tgaattccat acacctgttc tatcatctaa gcactcgcct
     9421 ttttctattg gttgacaagg acctgttggg tctaattctt tagtagcctt agcatctaac
     9481 cagctaactg ctccacaaag accaagtctt tcaggagtaa caacacaaac gtgagctggt
     9541 gcaaatgatt gacataagtt acaagaatag aaagtatcaa cactttcatc aactaatgaa
     9601 gctaatcttt catctctagc attgtactta gctattgctt ctccttttaa ttcagaaact
     9661 ttttcagcat ctgtaattat agttatttca cacttatcaa ctactgattc aaattcatct
     9721 aacatcttag catataaaac ttctcctata tgctcaagtc taaatccttt atcaaatgca
     9781 tctttagaga ttcttaccca agccatatct ctttgtccaa cgtgcattac accttctata
     9841 tagtttaaga agtagtggaa acgtctttca agaactggct cgaaatcttc ttgcatattt
     9901 ttaccagcta ttttaactat tacagcaagt ggtaatctta atacaccatc tgcatcaact
     9961 tcatctatat ttggtcctat tatttctatc ttatggtctt caacttctgt tgcttctttc
    10021 ttaacaacaa gctcccaagc ttcagttctg tttccaccaa actcagcaaa catatcgctc
    10081 tttctaattc tctcaccttc aaatgctgct gcaaatgaaa ctgggatagg tatttcagta
    10141 acttttattt ttattcctct agcttctaat gaagtagcta ctatcttatc gtaatctttt
    10201 tgagttaata ggttcattgg aacttcaaga actgtttggt cagttataac tgggaatcct
    10261 aaagctattg ctccagcacc tgcagataca actaattcac ttaatggtcc aaatgcatta
    10321 acaaatgcag gaactctatt agctgtgtac tctaataatc cgtttaaatc accaggagtt
    10381 aatccaccga atattaatgc tgctcttact gcaacagata caacgtgtat aacagaagtt
    10441 acatcatatc ctagaggtat aactcttagc tcaagaccca tttttactcc agcttctata
    10501 gcttggtcta taactttacc aactaagaaa gttagtaaac ctttagattg gtaatctttt
    10561 ataacttttg ctgctgattc tgcatctgga cactcaccaa gaacaactgc aacaccaggt
    10621 atatctcctg taactaatgg tacaccaagt gatctgatta tagggtcagt tatatgacct
    10681 gcacatggct cactatatgg agcatccata gttgaatatt ttaatgcttc aattacttct
    10741 gctgctaaag ctgtagctaa accagcatta aaagcatgtt ctagtaaatg agttctattt
    10801 attaaagatt ttactacttc taaagcacct tctaagtccc ctaaagtgtt catcttttgt
    10861 cctgttgcag catatataca aggtaatgaa tatgctgtat cagggaaagc aactttatgc
    10921 tcttttccat tcttttctat agcttcagct aacatagctt gagccgcacc taaagcttgt
    10981 tctgaccctg taaagattat attatataga ttcattctat ttcccccttt aatatttaca
    11041 cctatttttt attaactata ccctaaaaac cctagaaagc aaatccacct tcatttaact
    11101 ctaagaaaga gtctgcatat aaagatgccc cgttgattat gtcacaagat tttacagttt
    11161 tcattaattc tgggtcacat ggattcatta tagctgaact aaatccatta gccattgcca
    11221 ttgctaagaa tgcactatct aaaacaggtc taacatgctt aggacatcca ttagatacgt
    11281 tagataatcc tcctgtagtt aaaagtccca tctcagtcat catttttata gcttctaaaa
    11341 cttctacttg tttttcttgc atacctttta taactaagca taatgggtca aatagtatat
    11401 cagttggctc cattcctaac attaagcctt tttctaatat ttcttggcag taagccatac
    11461 gctcatcatt atctcttggg ataccttctt ttgcacataa acctataacc attgcttcgt
    11521 attcagctgc tatatctatt aaatcaaatc ttgaaccagc atcagcagag tttattattg
    11581 gttttgcatt agttctatca taaactttaa gtccagcttc gatagctttt ttattagctg
    11641 tatctaatgc tataggaaca ttgttgaact cagattgaag taatttgatt ccccatgtca
    11701 ttatttcttc gccatctctt tcggcaggtc ctatattaaa atctatatag tgtgctcctg
    11761 cttctaattg ctcttttgct ctttttaaga ttggagctgg gtctctttct gctaatgctt
    11821 ttcttattga aggtgatata caatgtattc tctcacctat aatcataaat ttttccattt
    11881 ataatgtccc cctttaaatt taatattaat agttagttaa tattttatta gtttgtttgg
    11941 catgcttttt cttggtatcc ttttaagaac ttaggtaatt ccatagattc ctctggtcct
    12001 ataactacat tccatcctgg taagttatct tctatatcac ctttaagtac tgcaactttt
    12061 cctggaatga taaggtcttt acaattagtt acttcttcta ccttactttc tttaatgaaa
    12121 gcagagattg agtttccacc aaatttacca gcagcccaag atgtaagaac tgaatatcca
    12181 cctgcatctg gtattactaa ccatactgga acttttgatc tttctatatc accagcaact
    12241 atgaagtaag ttaatgcaaa gtcaacagta actaatactg gagaattttc atctgggttg
    12301 ttgattggat aaatctttgg ttcaactctc attggtcttt gtgggtcagt gtatatgttt
    12361 tgtcttagtg caaataatgg taatgcctta gcataactaa tatcatctat tactattata
    12421 gaaccgtatt ttatagtgaa tattgatgat aaagcaactt ccatcatagg gtttgaatta
    12481 gataatctat ttgcaaatac tattgaagga tatccaaatg ttctatcttg ctcttttaaa
    12541 gctgttcttc taacttgtat agcattagtg taagtatctt ttatgttttc tcctgttaca
    12601 tctaatacta attctttata tccagcagct tgaattaatt caactgtttc atataattct
    12661 tctaagctac cagcttttac acctaatggt aaacttgctc ctttaactac ttctatcata
    12721 tctttgtagt tctctttagt tgctccatat accattggtc tagcatcttt taatacttca
    12781 acagcttctt taactacttg tgcatcatca caagctaaaa tataagctac ttctaatcca
    12841 ctgcctttta ttttatctat taattttaaa tacgcatctt tatctccaca atactctaaa
    12901 acagccattt caactttcat ttgttcacca attcttacat agtcaacttt tttcatgtta
    12961 gctattttag catctactgc ttcatcactc atacaagtac agaatgaaac tgcatatcta
    13021 tttctactta ctaatgtttt ttcatgtcta aataatactg tttctccacc tagttcatac
    13081 tcagatgcac cagcaccaac ttttaaagct ttcattaaag gtgcagtagc ctctgataat
    13141 tttgctatag cgtcatcaga catatgtggg catttaccta cttctacagc tcctgaagca
    13201 accttcatag agaaagccat acaagttggg aatccacaat ccttacagtt tttctttggt
    13261 gttaatttaa atatatctaa agcttttaat gccattattt tttcccccta accttaacaa
    13321 tttaattaag ctaatgcgtt aaccaattct tttatagttt ctattgattt tggatgacga
    13381 agtataactg cgtttgaacc acctactaaa acacttgctg cagttgaaac ttccattgct
    13441 atagttcttt cttctggaca accccaatct ggctcatctt ctattggagc tatagcttct
    13501 ttaacatgac ctacttcaaa agctactggt gttatgatag gcatttgtaa tgtcttatca
    13561 ttttgaccaa atgctgcaag tctaattcta tccatagtag atgcaacgta ctcatatcca
    13621 taaccaactg ctgaacatcc aacattcata actatatttt cacctttaac gcctagttga
    13681 gttaacaata cgtttaattg tttagctagg tttatatcaa cagaagattc agctcctact
    13741 ttatgtgcat aagccatacc agctgatgct cctactcctt tgtagttatc ttctactgct
    13801 gacataaata agcagttatg tccatccaat gtttgagcta atttttcaaa taatttacca
    13861 tctttttcat gatttcctga accagctaca actaaaggta attttattgc ttcaattact
    13921 gccttagcta catcagcaca ttcatcaact gacttatcta atccatttgg gtcagaacca
    13981 tcaaatttta aacaaataaa atctgcttgt gtattagctt caacatattt agcccactct
    14041 actggacaat tagctacatc tttgtataat tccttatatg aatcagtcca gctttcagga
    14101 taaacatctg atatttgtat ccctattttt ggagaattac ctacttctcc atcaaaacta
    14161 taaaaaggta atacattttc cccacctaat ttaattgctt tttcccctat tcctacttca
    14221 acttctgata tttttccaga atatttttga gtagacattt taaatgccat atttttttcc
    14281 cccttaagcc tattttaatt ctaatttagc aaaaatttct ttcatagcca ctttagattt
    14341 tgaatcttca ggtaaattaa ctaaaggaat acctgtagaa tcatattcat atatcaattc
    14401 atccataggt acaacaccga ttagctctag gttatgcttt tcaatttctt ctttaacacc
    14461 atcattcata accccatttg gaactttatt tacaatcaaa agtattcttc caacacttaa
    14521 ctttagttcc tcagctaaat ctcttattct agcaacagct tgtatgctac gtcttgagca
    14581 atcactaacc aataaaagtg tatcaacatg tctagtgact tttctactta gatgttccat
    14641 accagcttcg ttgtccatga ctaagtattt gtaatgacca gatattttgt ttacttgttc
    14701 tctaagtatc ccatttacaa aacagtaaca tccttcacct tctgacctac ccattactaa
    14761 taagtcatat ccttcgcctt cttcgattat agaatttaat ctaaattgaa gatattgtgc
    14821 ctttgtcata ccaccaggga atgcattgcc taacttttct ctttgattta cttcttctct
    14881 tatttctcct attgttgctt caacttcgat acctaatact tcatttatgt tagcattggc
    14941 atcagcatct acaactaata ctggtccctt tttgtcctta accaaataat caatcaaaag
    15001 ccctgtgaga cttgttttac cagttccacc ttttcctgca acagctatat tgtatcccat
    15061 tttaagactt cccccttaaa tctagccaca gagccttatg tactctgtct gtctattata
    15121 atttaggtac agaatgaaca cattctccat gtacatcatg aagtgcttcc attagccctt
    15181 cagataaact tggatgtgga tgtattgcat cccctacttg ttctactgtt aatcctagat
    15241 gaacagcaag tgacaactct gtcaataaat ctgtagcatg aggtcctact actgctgcac
    15301 ctattatctt atcagtttct ttgtcagcta taacttttac aaatccttgg aaatgtccta
    15361 tagcttgtgc ttttccaaga cctctaaaat caaattgacc tacattgtat tctacacctt
    15421 cagcttcaag ttgcttttca gtcttaccaa caccagcaac ttcaggttca gtataaacac
    15481 atcttggaat tgctctataa tctactacct tagtcttacc taaagcattt tcaactgcta
    15541 cgataccttc tttagaagca acatgtgcta ggaaaggagt atctattata tcgcctattg
    15601 cgtatatacc ttctacatta gtttcaagat gttcattaac tactactttt cctctttcca
    15661 tttcaattcc tatatcttct actccagaat tgtcaaggtt aggtcttcta ccaacacata
    15721 ctaatgcata ttgtgcttct ataacctttc cattagaaag agttgcaaca gccttaccat
    15781 caactacttc acaagtttgt actccaatac ctgtaataac cttaatttta tctttcttaa
    15841 attgtctaag tagttgttta gctacatctt tgtcttcatt taatagtatt tggtcaacca
    15901 tctcaactat agttacttct gttcccaagg ctctaaagaa ctgccctatc tcacatccta
    15961 taactccacc acctactatt aacatagact caggtatctc ttcaagtcca agaacttcat
    16021 cactagttat tacaactttt ccatcatatg ggaacattct tggtacaact ggaacagaac
    16081 catttgctag tattatctta tctgctttta tagtttctac tgttccatca tctttagtta
    16141 cttctatagt gtttttatca attaattttc caaaaccatt aactaagttt actcctcttt
    16201 tttcaaataa gaactctata ccacttatta attggtttac aactttattt tttctttcca
    16261 ttatggcagt gaagtttggc ttaactgtac catctatttc tataccaaaa tcctttgctt
    16321 cttttacagt attcaatact cctgaagaag caagaagtgc tttagttggt atacatcctg
    16381 catttaagca agttcctcca actcttcttt tttcaacaac tgttacatct gcaccaagca
    16441 tagaagcttt tatagctgct acatatcctc ctggtccacc acctactact actatcttca
    16501 tctttaattc ccccaaacct aatataatct acaatcttgc aatactataa acctgcggca
    16561 tccagtatag caggtatatt ctcttctgcc ccaattgcca ttatatgaac accatcacat
    16621 aaatcttctt cttttaattg tttgataagt tcccctgcca tttttattcc ttcacttacc
    16681 cagttttctt ttccagctgc tcttaatctt tcgatttgtt catctggaac aaatattcct
    16741 ggtacatttg cagtcataaa tttagccatt cctggtgatt ttaaaggtac tattcctgct
    16801 aataccttgc aatccatatc ccttgttaat tctctaaact ttctcattgt atttatgtca
    16861 taaagtgctt gtgtttggaa aaatttagcc cctgctttta ttttcttttt catttttaat
    16921 aattgaactt ctattggaga atattctgga gttactgatg ctcccagata aaaatctgga
    16981 gaacctttta acttattacc agccatgtcc gtacctgcca ttaaagtctc agcagtttga
    17041 agtatcccca cagaatctaa atcaaacact cccttagctt gtggatggtc tcctacgcta
    17101 gtatggtctc ctgttagtgc caacagattg tttatcccaa atacacctgc tgacaacatt
    17161 tctccttgta tagctattct atttctatct ctccctgtta tttgaataac tggctctaat
    17221 ccagcatctt ttaataattt acatgtagca agagaagttg ctctcataac tgccgattga
    17281 aagtctgtta catttgctgc atgaactctt ccaactaacg gctttgcaca ttctattaaa
    17341 tgtgaaaggt cagtcccttt tggaggagcc atttcagtag taactgcaaa ttttccactt
    17401 tctaatgttt ctcttaataa gctcatctct aatccccctt ttaaccttct aaaaaaaact
    17461 tttatgaatt tgctgctgct tctttctttt tctttgcact taaacttctt ggattatttt
    17521 gcttagaata gtcttttggt ggtcttattt ctgctaagtt atctaattgt cctatagctt
    17581 ctagtctttc atatatcttt atccaagcac aatcattctc tgagtttact tcacacttac
    17641 catttttagc tccaccacaa gccccattca taagaccttt agcacacata gttactggac
    17701 atatcccacc tgtccaacca agttcacagt ctccacaagc cttacaggct tcttcatatt
    17761 ctccaactct ttgtacttcc cctataaaca aagtattgtt ggctggataa actggcttat
    17821 cttttaaatt cttaactatt gtctgtgtac catctccaca tgctaaagat aaaactgcat
    17881 cagcttcctt agtctcttcc tttagagcct ttaaatcctt tttagacttt aaaaggttac
    17941 aagcagggtc aagcattaca tatcctaaga tttttttgcc ttcaccttca agagtttcct
    18001 tcatttttaa aacttcttct tccccaccac ttttacaagt tgctgcacat tgattacaac
    18061 caactaaaac cagcttgtca aaatctttta agtaccctag cacttcttct aatggtttat
    18121 tttcagaaat tatcatatct acttcccccc taaaccttcc acatatatat atctatttat
    18181 tgttttgtaa tttacaagcc ttaactacat gttttgcaag tatagatgtt gtaactgaac
    18241 caacccccgc tggaactgga gttatcattg atactttgtc taaaactgca tttgtatcaa
    18301 catctccaca taaatttcct tcttcatcaa catttatacc aacgtctata actaccgctc
    18361 catctttaac aaaactttca tcaaccatct tagctctacc aatagctgct attagcacgt
    18421 ctgcctctgc tgctacacct gatagatttt tagtttttga atgacatatt gtaacagttg
    18481 catgttcact taataaaagc attgatactg gctttccaac taccattgat cttccaagaa
    18541 ctgttacctt acttcctttt aaatcaacat tatagtgttt taatatctca actactgctg
    18601 taggtgtaca tggtggaaat ccacttttat ccccttccat taccttagca gagtttattg
    18661 gactaaaaca atctacgtct ttttccggtg caataacata ttttataact tcttcattta
    18721 agtgttttgg aagaggtcta aaacataata taccattaac atttttgtca tcattaactc
    18781 tctttaatac atcaatatat tcctcttgtg ttatatcctc agctaactct aacacttctg
    18841 ttgttatacc tatgttttga catctcttta gtgctcctct ttcataagat aaatcatcac
    18901 ttcttgcccc aactctaact attgttagtt taggatttat accttcttta attagtaaat
    18961 cgacttcttt tattaattct tcactaatct tatcagctac aggttttcct tttataattt
    19021 gtcctttagt tgacattcct tccatacatt cacaactccc ctacaagcaa acttaaatta
    19081 atttattcta tataccacat attaataaca tagtatctac tttcgtcatt taaaaattat
    19141 tttccaagag ctttttcaac tttggcataa acttcatcac aaatttttac accatcttca
    19201 actaacttat ctacttctgt ttttacctta ttaacatatt ctttatcttg tatagaattt
    19261 atatttataa ctacatttaa ttgtccacca agtatagcag ctcttaaaca ctgaactcct
    19321 acaccaacat cacttatagc aagtcttgaa cctttatcaa ctaaatcttc atgtaactta
    19381 atagcttcat agcaaactct tactatgttt aatggtactt cacaagcaac ttttaatgcc
    19441 ttttccattg tttctgcttt tattcttttt tcttcttctg tttctttagg aagcccgtaa
    19501 gcttttgata atggtaagaa acattctgca tcatcatcta tcatttttaa taaatctttt
    19561 tctaactttc ctgccttact taatatctct tttacacttt cttcatactc agcatacttc
    19621 ttcttcccta ttgtaaggtt acataccata ctacctaaag ccatacctat tgcacctact
    19681 agtgcagcag ctcccccacc acctggtact gcttctttgg aagatagtac ttctacaaaa
    19741 tcaacacaag ttttatctgc tattttcatg ataatcctcc ttgaaaggat gtaggaaaat
    19801 atctcaaatt gttcgagata ttttacgaac tattttaaga tatctcctac tctttattta
    19861 taaattaatt tccttagaat aatccagcta ttactccatt ttcatcaaca tctatttttt
    19921 ctgctgctgg aacttttggt aatcctggca tcttcattat ttctccagta agtgcaacta
    19981 taaatccagc tcctgctgaa attgttgctt gtcttacagt tattctaaat cctgttggtc
    20041 tacctaattt agtttggtca tcagttaaag aatattgagt tttagccata catactggaa
    20101 ctttagtaaa tccaagtttt tctaagttag ctatttcctt atcagcttca ggagtataat
    20161 ctacaccatc tgctccataa atcttagtag ctatagcatt tatcttgtct tttatagata
    20221 aatcatcttc atagcagaat ctaaagttat tttcttcttc atccaataat cttaaaactt
    20281 ctttagctac tgcaattcca ccttctccac cttttgccca tacttcagaa agagcaacat
    20341 taacacctaa ttccttacac ttgtcttcaa caagtttaag ttcagcttca gtatcaagtg
    20401 ggaatctatt gattgcaaca actgctggta atccatatac ttgagttatg ttttcaacat
    20461 gttttaataa gtttggaagt cctttttcaa gagcttctag gttttcgtta tttaagtctg
    20521 ctttagcaac tccaccattg tattttaatg ctcttacagt agcaactatt ataacagcat
    20581 ctggttttaa gtttgccatt ctacatttta tatctaagaa tttttctgct ccaaggtcag
    20641 caccgaaacc agcctcagtt attacataat ctgcaaagtg catagccatt cttgtagcta
    20701 taacagagtt acatccatga gctatatttg cgaatggtcc accgtgtaca aatgatggtg
    20761 ttccttcaag agtttgaact aggtttggtt ttaaagcatc ttttaataat gcagccatag
    20821 caccattagc ttttaattgt ctagctgtta caggttcacc ttcgtagctg tatccaacta
    20881 ttatgtttcc taatctttct tttaaatcag atatatcact tgccaaacag aacgctgcca
    20941 ttatttcaga agcaacagtt atatcgaatc catcttgtct aactgctcca tcaccttttt
    21001 tacccatacc atcaacgata tttctaagtt gtctatcgtt catgtctaca catcttctcc
    21061 aagttatttt cttagggtct attctaagtg catttccttg gtgaatatgg ttatcaagca
    21121 tagcagctaa aagattgtta gcagctccta tagcgtgaaa atctcctgtg aagtgtaagt
    21181 ttatatcttc cataggaaca acttgtgcat atcctccacc agctgctcca cctttaacac
    21241 caaatactgg tcctagagat ggttctctta aagcaactaa tacatttttg tctagtttag
    21301 caaatgcatc agcaacacct atagtagtag tagtttttcc ttcacctgct ggagttgggt
    21361 ttatagctgt agttagtatt aacttagctt ttttaccagt ctctcttttt agtagattgt
    21421 agtcaacttt tgctttgtat ttaccataaa gttctacatc atcttcacct agtcctaatt
    21481 tttttgcaac ctctctaata tcttgaggct tagcttcttg agctatttca atgtcagatt
    21541 taaatcccat aactgaatct cctcccacaa cctaaataga tttaaaatat aatttttgta
    21601 aaaattgtat taatatgtaa aaattatatt ttataagata attatacatg taaaattact
    21661 taaaaactag ctactaagct attaaaatat tcaaacttaa tagctagtta tttatctaat
    21721 tacttactta ttacctatct attgcctatg tctaaccttt aaccaactta aaatcccaaa
    21781 tcaaaatttc tatctatttt acttatcctt aagtgacatt aatttatctt ttattgcttt
    21841 aatctgttct ttcgttgttt cactagaatc atatggagat tgattagctc tatcagaatc
    21901 aataacatct tggttataat aaataaatcc taaagattct ccatcttcta agttttggat
    21961 tataaattct tcatcttcct tatttctaat tttatttcct actacaaata ctttatttac
    22021 acctatatca tgtccaagtt tcttaacttt tctataagtc tgtagacttc tctctcctgg
    22081 ttctacaact actataaaag catctacacc ttgggctgtt cctcttccta agtgttcaat
    22141 tcccgcttcc atatccataa ccactacatc tttattttgt agtattaaat gtgagcagag
    22201 tctcttcaaa agaacatgct ctggacatac acatccagta ccaccagaat ctacggttcc
    22261 caatgtaagt aatcttactc cattgtattc tttacagaaa ttttcaggga tatcgtctac
    22321 tttaggattc atcttaaaca tttttccaaa tgaacctaca gaagcagctg ttctatctga
    22381 aactaatttt ttcatttctg atataggtac tattgattca tatacttctt ttggaaaacc
    22441 tagtgctaaa gctaaattag catcagggtc ggcatcaaca gcaacaactc tgtatccgtc
    22501 ttcagcaaac atcctagaga gcattgaaga aaaagtcgtt ttacctactc cacctttacc
    22561 tgttattgct atcttcataa tccctaccac cttttattac tatttgcttt ttagtagtta
    22621 attttacagt taaatatttt ttatactcta tatttttata cactaaaaat aaactacagc
    22681 tagtccttac aggaaccaat taaatttacc ctactagctt ttcaaagcag catgtatagt
    22741 tttattattc tttaatattg tttatatttt atttattcag tatattcatt atattttgat
    22801 gttctttact ttaatatttg actttattca actttattca accagaaact tcttataaaa
    22861 acgtttattc tataacttca ctatttttta agcttcagcc ttttctgcca ttttttcttc
    22921 aactaatgct tcaaagtgaa cacgtttttt ctctatatct tctattattg tagctgctaa
    22981 ctcttttgga tttgtattta cagtaaatgt agctccaact ttatctttta attcactagt
    23041 taatatatcc actgctcttg aagaaccagc tattggaggc attattccta aataagtgtc
    23101 tataccagaa gctacaacat agcatcctat agcaactgct ttttctgaca tccactctgg
    23161 agctatacct acaactggaa ggtcacacat atccatatct aagtaattag ctgctgctcc
    23221 aactaaatct agtatacggc ttatatcaac acaagaaccc atatgtagta ctggtgggat
    23281 tcctactaat ttacagacag ttgcaagacc tttacctgca tatttttcag ccgcatcaga
    23341 ttccattaaa ccaaacttag ctgctgctga agctccacaa cctgtagtaa ctactattat
    23401 gtcgtttttg attaattctt tcattattgt tacgtgagcc tcatttgaaa ctcctttagc
    23461 attgttacat ccaactacac cagctgctcc tcttaatact ccagctttta aacagtctgt
    23521 taatggctta actgttcctg ctgggtctat atgagagttt acaactctgt ctaattgatt
    23581 tactactgct tctacactat acccaactgt tgcgcctgat tttaattcag gtataagtac
    23641 ttttgattta tctctatttt taaagtttaa aatagcttct ttaactattg ctttagcatc
    23701 atcaagtgct tgttcttctc taaattcaat ataagttgaa cctgttatct tagcttttgg
    23761 agaagttgtt acaaatttag tatggtaaca atctgcaact ctagctaatg cagggaatat
    23821 acattgaacg tcaactatta cagcttcaac tgctccagtt attattgcaa gttcttgttg
    23881 atggaagtct cctgctattt ttacaccatg tctcattgta atctcattac ctgtacaaca
    23941 catacctgct aagtttattc catcagcacc aacttcttta gctaaagcta ctaagtctgg
    24001 ctcttctgat gctaaaacta tcatttctga taatgctggc tcatgtccat gtaatattat
    24061 gttaacttta ttttcttcta atactgctaa attcgcctct gttcttcttg gcactggagt
    24121 tccaaataag atatcgctta gacgagtacc tatcatagaa ccaccccaac catcagccat
    24181 agaagttcta agactcatgt gtattaaact atctatatca ccagtacatc ctatatgagt
    24241 agagtgcatt attgttgcaa tttctctatc tatagctctt ggctctatag cgtattcttt
    24301 ccatattttt tgtcttggtt ctggtgcatt ttttataaat cttaatgtcc caaaaggttt
    24361 tccaaattcc attaatgcaa tttctgccac ttcatgtgct acatcataga tatctctacc
    24421 ttctgtctct acatcccatt ctttagctaa agtaattaac ttagcttcgt ctcttatttt
    24481 atagtttcca tttggatcag ctaatgctaa tgtatgtgct atatctctag catggtctga
    24541 atgggcagct gtcccaccag caaccattct tgcaaagttt ctacctacta tagtatgctc
    24601 atctgctcca cataaccccc ttggagtctt agggcttatt ctacatggtc ccattccaca
    24661 tattctacag caaacacctt gaagaccaaa accacattgt gccttaaagc cttcttttct
    24721 atcatacatt gtttctacgc cttcttctct agctttagct atcatcttct ggctgtttaa
    24781 atcaattgtt aacatttttt catccatatt cctatcccct ttttttgatt tttaaaatcc
    24841 cccaggtgac tgacttcatg tcataaaata ataaaataaa tgctttctaa gttgattata
    24901 tactaatttt cagtgctttg ctttagattt aaatattttt ttaacaaaat tagataatac
    24961 ataaaaattt tattttctac acttaattta agttgatttt atcgcttgtt tttggctatt
    25021 tgttaatatc taaacctact tttttgatac ttcagtttaa ttaaattatg ttttgatttt
    25081 tttaaatcaa atttgaaatt tttctagtca tttttatatt attgcagatt gtttgtgtat
    25141 ttattatctt tcactactgt ttggacttat tacagatttt tactccctaa acttaattag
    25201 taaaaatttc ttagaatagc attttttgga ctaatttttt tgaatttttt tatttttcct
    25261 actttaatat taattatagc ttcaaattga acatttgtat atattcattt gaagctataa
    25321 ttatttttta tataaaactt ttttaataca gcattaattt agacattttg actatttttt
    25381 ctactttaat tcatttattt caagcgattt atcctatttc atatttttag ctacaatagc
    25441 cccatatgca atagaatata atttagattc atgtgaatca gctcttgaca ctaaaactat
    25501 aggagctttt gcacccataa ttatacctgc tgatttagag tctgccatat atgtaaaggc
    25561 tttccctatt ccattaccaa cctctattgt tggaaccaat atgatatcta catctccaga
    25621 tacttcactt ttaaaccctt ttatctcact agcttctttt gaaacagcta aatcaaaagc
    25681 cagaggacct tctacaatta cattttcacc aaattctcct tctttacaag cttttgctaa
    25741 catatctgca tctacagttg cttgcatctt aggatttact ttctctttag ctgccaaaca
    25801 tgcaactttt acagtttcca ttcctaaagc ttttgcagct tttatagaat tttttaatat
    25861 ctttgccttt tgttcataat caggagctat attcatacct ccatctgtag ttataagtaa
    25921 tttatggtat ttttctaact catataccat aacatgactt aataaactat cagttctaag
    25981 accatagtct ttatttaaca cttcttttaa tatgacagat gtatctaata atcctttcat
    26041 tacaaagtca gcttctttac ttgatactaa tttaactgct atttctgcac actctttgat
    26101 atcatcctta tccactattt tgataccact taaatcaaat cctatttctt ttgatatttc
    26161 tcttattttg ccttcatttc caaccaatat aggagtaatt atatttcttt ctacagcatc
    26221 ctttattgcc attaaaactt ctttatcatg agctgctgct acagagagta caattttctc
    26281 tcctccctta agttgttcta aaatatcatc taattttttt atcaaaagta acccctccct
    26341 tatatatatt taactaaata ataccatatt tgctatacct tttctcaatt tattttttat
    26401 gttataaaga atttatataa ctaaaagaca gtttaatatt ttattctggg atttcatcaa
    26461 tagctcttaa aagctttgca ggaacaccac ctacaatagt attttctgca acattttttg
    26521 ttacaactgc tccagcagcg ataattgcat tatctccaat agtaactcct ggaactacag
    26581 ttacattagc accaatccat acattttttc ctattgtgat tggagaagga taagttgtac
    26641 cacgtttctc tggtgcaata ccatggttaa gtgtagccaa taccacatta tgcccaattt
    26701 gcgtattatc tccaatctca atccccccct ggtcttgaaa atggcaactg ctatttataa
    26761 aaacattttt tcctattgtg atgttttttc cacaatctgt ataaaatggt ggaaacataa
    26821 aaaatgattc atctaccttt tttccaatta actcagaaaa taaactacgg acttcttctg
    26881 gttcatgata agaagaattt aacttacttg tgattttcat tgcctcatta ctcaacttaa
    26941 ccataaattc atgtatttct gatttactag aaacaggttt tctttgattg atatgtgtta
    27001 aaaattcatt gatattcatt ttatacatcc tttcaatatg tgctttaatt tatttgtaca
    27061 ttctaaataa tattttaata aaaattaatt taatttattt ttattaaaat atcattgctt
    27121 cttttagtgt aatatacaat tatatctata tcaaatatct atattaaata cttaactata
    27181 cttaaaaagc atataaattg atataattat ataataaata agttaatatt gaggagggat
    27241 aattatggaa ataagagtat taagatattt tttagcaatt gcaagagaag aaagtatatc
    27301 tggtgcggca acctttttac atataacaca accaacactt tctagacaaa ttatggaact
    27361 tgaagaagag ttgggagtta aattattggt tcgaggaaat agaaaaatca ccttaacaaa
    27421 tgaaggtagg cttttacata aaagagcaga ggaaattata tcattagttg ataaggttga
    27481 attagaattt gacaatccca atgagattat tagtggtgat atatatatag gaagtggtga
    27541 aactgaagct atgcgactta tagctagaac tgcccatcat tttcatcaaa aataccccaa
    27601 tgtaagatat caccttttta gtgggaatgc tgatgatgtg actgaaaaat tagacaaggg
    27661 actgcttgat tttggtattt taattgaacc tgcaaatata cagaagtatg attatgcaca
    27721 aattcctgct actgatgtat ggggtttact aatgcgtaaa gatagtgccc ttgcatcaca
    27781 aagcacaata aatccaaaag atttatgcaa tatacctctt attatttcaa gacagacact
    27841 tgttgataaa gcaatttcta aatggcttca aggcagtaat gaaaaactaa acattattgc
    27901 aacatacaat ttagtttata acgcttctct tttggtagaa gaaggtctgg gctacgctct
    27961 gtgtttagat agactcgtca atactacaga aaacagtaat ctttgtttta gacctctatc
    28021 tcctccttta gaagctaaat taaatattat atggaaaaaa catcaaatat tttcaaaggc
    28081 agcagaaaaa tttttacttc aaatacaaaa agatttttct tctatcatgt tggatacatc
    28141 taagttggat acacctaaag aaaaataaat cataataaaa agtgagagtg tctcaaaatg
    28201 aactttgcac tgtataaggc actctttttt atacaaagta aaatatatgt tcatcatttc
    28261 agcactaaaa aagaggctta tctctatttt gagatagccc cacttaacca ataaaattaa
    28321 atacaactta acaatatcct tacttattta ttccaagttc tcttagacaa gcaatcgtaa
    28381 tttcatcttg tggatttaat tcataagctc tttctatata gtaagttgca tcatcaatat
    28441 caccattatt taaataagcc attcctaaat tgcaaagtat ttctgggtct tcctttatct
    28501 tagccgcttg ttcaaaatac tctattgctt tatctaaatt attcttataa gcctcacaaa
    28561 gccccaattc cactatagta tccacctgat taggctttat tatcaatatc ttctcaagat
    28621 acatcttagc ctgctctatt tcgcccatac ccttatatcc aagtgctatc ataaacagca
    28681 agttccacca atccatatgt tcttcttcta atggaagtaa cttctctaat ccttccttaa
    28741 acttaccttg gaatacaagt gtatatcctt cttcatattg aactttaaag tccatcttgc
    28801 ccagattctc ttgtacctca gctactaaat cagcatctaa ccctagcctt aacgcttctt
    28861 cccaagtcag cttagtcttt aaatattgac cttgattata ataatggtag cctaagtgat
    28921 aataacctaa tgcaaaattc tcatcaacat caattacctt ttcaagctta gccatggctt
    28981 caagtaagaa tgcattcatt gccttatcat ccatatcttt ttgatactgt ttagctatct
    29041 cttggcaaac aatcgcatag ttatacattg catctaaatc atctggatac attgttataa
    29101 atgcttttat atatattaaa gaatctgtat gttcaccaat ctcaaagtat tttctcgaca
    29161 tatatcccat atacgatttc aaatccaaat caatatcttt tgataaagca tttaaaaact
    29221 tctcatactc tgcattgttt ttaaacttac tatctattcc aattatatat atcattgcat
    29281 ctgctataga cattgaattt aacttatctt gagcagtctt ttcttttatc ccttttacta
    29341 atacctcatt ttttataggt acatctaatc caccttttgg cacttcatag ctttttaatt
    29401 taaactctcc accatgtttt atagttataa aagctaattc ttctgctttt tttagcaaat
    29461 atttttctat cttaaaatcc attttatcct cctaaatact taaatctcta ctttatgagt
    29521 tttagatttc tcaaatattt ttttatcatc atactcaaat aagactacat tttctacttc
    29581 tcttatttct gtatttatat cattttttaa atccacaaca ttaaatctaa atggctcaaa
    29641 atgaacatat tttattatat gtttagctgg tttatcaaca aaactaggta aatatgttga
    29701 taagttatca ttatcttgta aaaatacatg gcatctattc ttaaaatcat ccacatctag
    29761 cttattaaaa aactgtggta tatttgatgt tttacccagt gatatatagt catattttaa
    29821 tatatcgttg aatacatcat tatctatgtt gattttttca ttatagaaat ccatcaatat
    29881 tttatataac tgattctttc cttgtgccaa atcaaagtag ccattttcat caaaatactt
    29941 ggcaaaaacc tcaaagaatt taaaagggct ttttttataa aatctgccta taatatatct
    30001 catagataac acaaagtttt tagaattgta gtatctctcc agtatatctt ctatatcctt
    30061 tagcttcaaa gtttcttcat agcttatata attattgtat aaaaactcat atggagcata
    30121 atccttatat ttaaaaccat gctcatctgc aacttttctc atacctgtcc ctttaatcat
    30181 ctttaaaaag cctaattgca gatgctctat acctagatta aatacatcat taaaagaatt
    30241 ttcaaagctc ttataatctt cataaggcag tcctgcaatt aagtctaagt gttgatgtat
    30301 atttctataa gatgctacag tttgtacaac atgagacaac tttttaaaat catcccttct
    30361 acctactgca tcaagtgttt tttcattcgt tgactgaacc cctatttcaa attgaaaaag
    30421 accttcttta caatcagcca aaaactcaag catcttatca tctatcaaat acgctgtaac
    30481 ttcaaaatga taagttgtat atccattatc atttttcata agaaaatcca tgatttccat
    30541 agccactttt ctatttgcat tgaatgtcct atctataaac tttatttgtg atactcttgc
    30601 atctattaaa gcttttaaat cactctttat cctgtctaaa ctaaaatacc ttagacctgg
    30661 aatagtagat gataaacagt attggcagtt aaaagggcaa cctcttgatg attcataata
    30721 cactattcta ttttcatatt cttttggatt caagttttca taaggactag gaatctcatc
    30781 caaatcttga agtaattcca taggcttatt cactattatc tcattgcctt gtctatatac
    30841 aagtccattt acatcattta tttccatctt tccttgcaag tgaagtacta aatctctaaa
    30901 aattaattct ccctctccat aaagtatata atccacaaaa tcatactttt tcattgcctc
    30961 ataactatca taactcactt ccggtccgcc caaagctatt ttagtattag gtctaatttt
    31021 ttttagatta tcacaaagtt taactatatc tcccacattc cagatatatg ttgagaataa
    31081 tattatatca tattcatttt tatatatatc ctttaaaata tagtccaaat cgttgtttat
    31141 cgtgtattct ttcatattaa cttctatcaa atctcttaca aattctttta gatatcttat
    31201 agccaaattt gtatgaataa acttggaatt taatgttgtt aataaaattt tcaaatattt
    31261 ctcacctctt tttaagatta tactgtcttt ttgtacccct tataggttaa aatagtatat
    31321 gtaaagtcta aataatatct atataattaa tttattaatt tcaagtaatg tgaggaaagg
    31381 aagtttttta tggaattaat tgaaaaagta tctatcaact ctttatcaaa aagagattta
    31441 ctacttatta taaagtctct tgaatacact aatgaaaata ctcaaattag tgatttcatt
    31501 gaccttagga ataatatagt aaaggaatta tgttttttaa ctgacactaa ggaaaaagat
    31561 tttttagatt atctagaaaa aaatagcaca ctctaataac ctaaaccttt ttaaacttta
    31621 atatataaat acctgattta gaatttattt ttatgcttaa tatattatca ttaaaggttt
    31681 tcgacataac tgttatttga ttaaatatag ggtctactat agtattacct tcttcaagtc
    31741 ttataagact tcttgggtct atgcttttat tatatgcctt aactccaatt ttatattttc
    31801 tcaatttaac aacatattcg gacatagaaa aaataaaatc tatattatct tcatttaatt
    31861 tactatcttc acccaaaatg gataatatag atttttttat gctattaatt ccttcatttt
    31921 ctacagttct atcttccata tatacatcat atagaacatt taaaacattt aataaaatac
    31981 tttcttcatc ataatcttca gatttcaaat caatgtactt atcaattaat tgtattgctt
    32041 taatccttgc catctgaaac tttacaacat ctgatttgtc taattctata gaaaatccta
    32101 ttatcttgtc tttaatactc tgtagtaatt cgacatactc tattttacta ttatttataa
    32161 gattgtgcat aatggaatta tacaccacag aacctaataa ataatcaaat aaaagttctt
    32221 cttttttaaa ataaataaca tactttttta ttagtttaat aacctcatct tcactttttt
    32281 gaatattagt atttgataaa attagtggta ataaaatatt taaaaaattg atatttccta
    32341 ttttttctcc ataaaatcta tagtaaataa gttcatctct cagtctattt tcgtctatat
    32401 acacacatct ttgcgtttta tcatctatta aggattttgt atttattata gttaaatctt
    32461 taagagccct acttgcacta ctaaaagaag atgtgtagac tttttttagt aattcgtcat
    32521 tcataaatat atcctttctg aaaaattgaa tgtaaataaa ttgttattaa aaaaaaagag
    32581 acagcccgtt taagaagctg tcatatatag ggggatagta gtgtacaaaa atcattgtaa
    32641 tctactatct atatattatt atacgatact acttttttat atgtaaagca tcagttttcg
    32701 acatccctat attttacagt tatacaaatt gcgtactaag ttcaatttta ttctttttat
    32761 ttcaacattt tatcatgcta cattctttca ggagcgtgca ttcccaacaa tttcagagaa
    32821 ttttctaaag tttgttttgt tgctaaaact aatgcaagtc ttgcttttct tatttccaaa
    32881 ttttctacta aaattggatt gtcatgataa aatttattaa acgcttgagc taaatctagc
    32941 ataaatctag tcactatatg tggctcattt ttctttagag caagtaaaat attcttattg
    33001 aatgattcta taactctaag aacttctgca ctatcttcat cagctaatag actataatct
    33061 atatcagaag tcacttctac ttctgctttt cttaaaactg cacagcatct agcatgtgta
    33121 tactgaacat atggtccagt ctcaccatca aaactaagcg ttctttccca agagaaggta
    33181 tagtctttaa ttctactatt agataactct tggaatacta ctgccccaac acctacttgc
    33241 ttagatattt catccacatt tttagcattt gggtttttag ctagtataat ttccttagtt
    33301 ttatctatag cttgatttaa agcatcttct aaaaatacta ctcttccttt tctagtcgac
    33361 atagtacctt cttcaagtgc aaccatacca aatccaacat gaattaaatc ttttgcccaa
    33421 tcatatccca taagctcaat taccttaaac cattgttgga aatgtaagtt ttgttgagaa
    33481 ccaactacat atatacactt gtcaaaatca taagtttctt ttctatatat tgcagcagct
    33541 aaatctcttg tcatatataa cgttgaacca tcattcttag taataagtgc tggtggcatt
    33601 ttatactctt ctaaatcaac aattcttgct cctttagact cttttaaaag atttttctct
    33661 tctaatagtt cgataactct gttcatttta tcagaataaa aactctctcc tgctaaagaa
    33721 tcaaattcta tatctaaaag tttataaact ctgttaaact cttttaaact ctcatttcta
    33781 aaccattgcc ataattcttg tgcttcttcg tcaccatttt ctaatttatt aaaccatgct
    33841 cttgcttcat cttccatttc tgggtgttgt tcagcttcat catggaatct tacgtataat
    33901 tttagtaatt ctggaattgg attagactct actacttctt tttctcccca ctttttaaag
    33961 gccactatta acttaccaaa ctgagttcca tagtcaccta aatgatttat tcttatagtc
    34021 ttgtatcctt gcgaatcata tatcttatat aaagcattac ctataactgt agttcttatg
    34081 tgccctatat ggaaaggttt tgctatattt ggagaagaat attcaactat tacagtttta
    34141 tcttttccaa aatcactatg tccgtaattt tctttttcat ctaaaacttt tttaattaca
    34201 gtttctgcta attgagattt atttacaaag aaatttacat atccgcctaa ttgtattact
    34261 tttgttatct ctccacttgg ttctatactt tccgccaatt cacttgctat catgtttgga
    34321 gcttttctaa acactttggc taatttaaag catggaaaag catagtcccc catatcctta
    34381 tttggtggaa cttctataag tgcctctatc tcttctttcg ataaatcttc tattttttct
    34441 ttaaggcaat ttgatattgc caccttaaaa tcttgcattc tgttgctcct ctctacattg
    34501 ttcctggttt atattgtgct tatctcttta tgttaaatca aatttcgtgt tttttcaagt
    34561 atttcattac agtgtaaaac actttagtaa ttatgttttc tgtatatatt aaaaatacta
    34621 taatttcagt ttttaatcac actattattg attttttata agactttttt ctattttatt
    34681 gtttcttgta ctatccagtt gactttatat acttttttta atcttttatc tgttttcata
    34741 catcaatgtc agctttatat acattttttt aatcttttat ctattttcat acatcaatgt
    34801 cagctttata tacttttttt acttttttat ctatttttat acatcaatat tagctttata
    34861 tacttttttt actcttttat ctattttcta taaatctttt tcactcttaa cttttattcc
    34921 ttcttcttct aatagccttg ctgttatacc tttccctggt atctttttac ctgaaaaact
    34981 accatcatat attagattac atccacaaga ggggctaccc tcttttagta ttgcttcgct
    35041 acatacatat aaatttgcta tttttagagt ttcattagcc cctcttacaa agttttctgt
    35101 tacatcctta ttatctttag taattacttt tccatcaact atctcagcag gtggtcttgg
    35161 tgtagataga ccacctaact gctctgggca tacaagtgta aattctttgc cttttaaata
    35221 ttccttgact ttttcattat cattattatc gccactatat ttacaattta ttcctattaa
    35281 acatgcagat accaatatca taaaaatgtg ctcctataca aattatatat attctcatac
    35341 aaattactaa tgtattctta tacaaattat tttaatttaa caattgttac tcctgctcca
    35401 ccttctccat attgaccacc tctttgtgat tttacatgtc tatttcttct taaaatgtct
    35461 tgtagccctg cttttaatac tcctgtacct attccatgta ttactgttac agactctaaa
    35521 cctgccacat atgcatcatc aagatacttt tctacttcca ttatagcttc ttctaggttt
    35581 aaccctctaa ggtcaacttc attttttaca ctaccagatt ttgaccttat aatgtttctc
    35641 gttgatttag ttacatttgt tgaaacatct ttgcgtgttt tttgtaaaga tttaaaaggt
    35701 agagtcatct tcattatacc aatttgcact actgcttctt ttctcttttt atctactgaa
    35761 actacactac cattttgatt taaagttatt accttaactt cttcacctgg ctttaagtct
    35821 tttatctcct tatttgatac ctttggaact atcatacttt ttactgttgg ctgaagactt
    35881 cccatagagc tagtcaattc ttttctaagt tcttctatct tacgattctt ttcttttgaa
    35941 gctctttctt gttcaagact tctaagttct tttattataa tatctacttc ttctttagct
    36001 tgtcttataa ttgaaaatgc ttctgattta gctttttcaa tcatcttatc tctttgactg
    36061 accaattttt caagtttttc gtcatactct actttcagtt tttcaatctc ttcttttaat
    36121 ctttcagctt cttctctatc ttctactgct ttgattctat tcttttcaac attctgtaac
    36181 acatcttcta aagctatgtt ttctgtattt atatattctt tagcacgtga aatcacataa
    36241 tcacttagcc caagttttct agaaatctca aacgcatttg attttccggg aacacctata
    36301 agtaacttat atgttgggct taaagtttct atatcaaatt caactgctgc gttttctaca
    36361 cctggtttag taagagcata atttttaagc tcactatagt gagtggtagc tatacattta
    36421 gctcctacag aatttatatc ttctaatact gctattgcaa gggcagctcc ttcaacaggg
    36481 tctgttcctg ctcctaactc gtcaaatata actaaagagt ctgctgttac gttttgtaat
    36541 atagatacta tattcgtcat atgagatgaa aatgttgata gactctgttc aatactctgc
    36601 tcatctccta tatctgcaaa tacattatca tatacacaca tactacttcc ataatcagca
    36661 ggtatatgaa gtccactttg tgtcataagt gcaaatagac ctacagtttt tattgtaaca
    36721 gtcttaccac ctgtgtttgg acctgttatc accaatgtat ggaagtctct tcctaaataa
    36781 atggtatttg ctactacctt ctttttatcc agcagtggat gtcttccatt ttttatgttt
    36841 aaatatttat cctcatttaa agttggttct attcctctca tctgtataga aagttttccc
    36901 tttgaaaatg caaagtccaa tcttccaagt atctcttgat tagagattaa atcttcgctc
    36961 acttctccaa ccatagcaga aagctctgat aaaattcttt ctatttcttc ttgctcacct
    37021 agttttaact gtctcaattc attgttcatc tctactatag tcattggctc tataaaaagt
    37081 gtcgcaccag aagatgactg gtcatgcact ataccagcta cttgcgacct atattcagat
    37141 tttacaggta ctacaaatct atcacctctt agagaaatta ttgcatcttg taagtacttt
    37201 tgataagtag ttgaacttat tattgaattt aattttgacc taatggattg atttttttgg
    37261 gctattcttc ttctgatatc tctaagtgta cttgaagcat tgtcagatat ttctacttca
    37321 ctaattatag cattgtatat ctggtcttct atgtccttgt atacatatag agaatttgat
    37381 agagattgta ttattggata attaaaatct tcttcatcac tactagataa gctatttctt
    37441 aatcttctag ccactcttaa ggtatctgct atcataatca gacttcctgg gtcaagagaa
    37501 gcacctatat aagctctctt taccttatct tctatatcat gaataccttc caaccctact
    37561 gaacctctct ttataataat tgattgagct tcactagttt cttctagcat agatttcact
    37621 tctacaaaat cagtatttgg tactaaattt tctatatatt ttagacctaa agaagatgag
    37681 gctttcttct ttaacaaatc tattatttta ttgtattcta gaactcttaa cgatttctca
    37741 ttcattttct atattcacca tcctcgatat tttaactttt ttatttaatt ttaaaaatgt
    37801 atgttttcaa gcatttccaa taaaaactgc aagttttatt tctttttcat ttctaaaatt
    37861 attatatttt ttctctttta gatatatttt acacatattt tgtattatac tatgtatgta
    37921 gctatctata tattatacat aaacatgctt tatttgtaat ataatctgtt aaaaaatctt
    37981 ctttaatatt tttaaaggag tttattttag cttataaaaa aaaatagcta cttatataga
    38041 taaattaagg aggaacatga gtcatgggaa acgtattaga aggattaaaa ccagaaagtg
    38101 tttttaaaaa ctttgagaaa atatctcaaa ttcctagagg ttctggaaat gaaaaaggca
    38161 taagtgattt tttacttagc tttggtaaaa atttaggtct tgaaactatt caggatgaaa
    38221 gcttaaacat aataataaga aagcctgcta caaaaggata tgaaaattgt ccaggtgtag
    38281 ttcttcaagg acatatggat atggtttgcg aaaaagaaaa gaatgttgaa catgattttc
    38341 ttaaagaccc tataaaatta agaattgatg gtgacatgat atatgctact ggaactactc
    38401 taggagctga caatggtata gctgttgcta tgggtatggc tatattagaa gataatactt
    38461 tagagcatcc tgcactagaa gttttagtta ctgttaatga agaagatggt atgaatggtg
    38521 cagatgcact agaccctagc ttaattaaag gtcaatatat cctaaatatg gactccgagg
    38581 aggaaggata cttattagtt agctgtgctg gtggtaaaac ttgtgttgtt agtttacctg
    38641 ttgaatacaa ggaagttaaa ggtgacaaac aaggattatt agttgaggtt actggactat
    38701 taggtggaca ctctggtatg gaaattgttt tacaaagagc aaatgctaac aaagcaatag
    38761 ctagagtatt aagtgtattg aatgttgatt atgaattagc ttctgttgat ggtggtacta
    38821 agcacaatgc tatacctcgt gaagctaaat gtgtaatagc tgttaataaa gctgatgttg
    38881 aatctgctaa aaaacaaata aatgacattt taactgcatt taaacatgag tttactactt
    38941 ctgaccctgg catgacttac tcagtagctg aaacttctgt agacaaagtt cttactaaag
    39001 attgtaaaga aaaagttgtt caaatgtctt gcttaactcc tcatggagtt caatcagtaa
    39061 gtcttgatat agaaggatta gttgaaagtt ctactaactt cgctataatc gaaactaaag
    39121 aatctactat tgaattttta acttctgtta gaagttctgt tatgtctatt agagatgaaa
    39181 tcgctgatag aataagactt ttggctcaag ctttaggtgc taattacgac cttatagctc
    39241 aatacccagc ttgggaattt aaaaaaggct caaaattaga aaaaatatgc agtgaaactt
    39301 atgagaaatt aactggtaaa gttcctactg ttatggctct acatgctggt cttgagtgtg
    39361 gattattact tgataaactt cctcatgctg aagctatctc tataggacca gatatgtttg
    39421 atgttcatac tccaaatgaa catgttagta tcccttctgt agctaatgtt tgggattatg
    39481 ttattgaaat attaaaatct atgaaccaat attaaattta agttttgatt ctaagtagat
    39541 tttaatttta agtaatctat ataaaattaa ctctgtaaat taatactacg gttagtataa
    39601 tatttacttt caatattaac ttatagaaat aaagcctaat gatagataat aacatgtatc
    39661 attaggcttt attgtaattt aaatattatt aagctttatt ctgttttaaa attaattctt
    39721 atactatttt aaatctattt cttccttgtc tcttagaatc ataaagagca ttatctgcta
    39781 tttgatacag ttcatcatac tcttgaccag gctttgctat aactaccccc atactaatag
    39841 ataaactttc tccatttggc aacttaatga gatgaatatg attgtataca tcattacatt
    39901 tattaataag ttcttcctta tttattatat cattgatata aacactaaat tcatctccac
    39961 ccaaacgacc tactatatca ttttttgcaa aactttcatc aagtgccttt gcaacatcaa
    40021 taagtacttt atctcctaac aagtgaccat aagtatcatt aatcgattta aaataatcaa
    40081 tatctataat caataaagca ccattttttt cagttgataa attcaacaaa ttttgtgaag
    40141 ttaattttct aatatatgct gcattataaa tattggttaa actatccctt tgagccttat
    40201 ctaacaatct attcttttcc tctttttcag aatcaatatt acatattttc ccgattacat
    40261 acattggtat ttttctatca ttataaatta tttttgaagt aactctaatc caatgaaaag
    40321 tatcatcaag cataatagaa tacatttcag ttgttccatt ttcttgtgat tttattacat
    40381 caaaaaactt tttattatat tctttcctta ttttatctct ttcattttct atattgccat
    40441 tttcactttc cttatcattt ttatccaaac cataataagt ctcaataccc ttttctggca
    40501 tagaaattat caatttatct tgcttataat catactcaaa aaagtattca cttgtcattt
    40561 catacaactg agtatgtttt ttgagttcta aagatatctt ctcgttcata cttgtacgag
    40621 tatgtaaacc aaatgccata aatccaataa tacaaattaa taaactggct acaataaaaa
    40681 tagtctcaat tggattctgt tgcataatat aaagcaacga gaaatcttgt ctatatgtag
    40741 tattttggta gacaattgat tgcatttttt ctgatgaaat acttataata gctttattaa
    40801 atatattcaa taattcttgt ttatcttttt taattatacc aaaacaaata ctctttgctt
    40861 tataggtttg aggaactaga cgcacatttt tatacttagg ttgattcata tagtactgca
    40921 tagaataacc ttcgccataa gtgtaatctg catagccttt attaacagct tctatacact
    40981 cttctaaatt atcataccaa actatattct cttcaaactg accataataa ttaatacctt
    41041 tggctagagc tacacgtttt ccatctaaac tattctcatt taatttatta ttaatcatca
    41101 tagtatattg agtagaaaga aaaggccgag acatagctat attatgttca cgagagtatt
    41161 cataatcata aatcattcct gctacaatat caatttcacg ctttttagtc atgttttcta
    41221 aatcttcttg agattttaca ggcacaagtt caaattctaa gcctgtttta tcacatatat
    41281 gatttaacaa atcaattgat atacctctta attcacctgt atctttatct atattttgaa
    41341 atggtggttt gtttaaaagt actcctactt ttaatttttc tgtctcttta atgtaattag
    41401 tttcttcatc agataaaaac atttgattat tctctggtgt aaagtatttt tcatataaag
    41461 tagttgaaaa atatgggtct ttctgttcaa tattattaat tgctgagtta agcttttgag
    41521 ttaaatttgt actaccttta ggagtaatga aataaaatgg ttttgatgaa aattttgcta
    41581 cagtacgtac accttctatt gggttcatac tcacattaag aagtacatct gctttaccac
    41641 tctttagtgc ttctagttgc tcatcatttg ttttacaata taccaattca ggtgacataa
    41701 gattcatttt acaatactca tctaattctt taagtctagt atcagaattt tctattacag
    41761 caatacggat ttttttcaca tcttgtgaac tcattatgtt atcaatatct gtattttcat
    41821 ataatgcttg tagtactgta tttgctactc cataattatt ccctgcataa ttatatattt
    41881 tttgcattgg ttcattgtat aacatacctc ccattatatc aatttcacca ttttctaaca
    41941 tcttcattaa ttttgtaata gattcattta tctctccagg aacttgaaca aattcataat
    42001 tccatccagt atactgtgca atttctagta aatattcata tgtataccca aaatagttac
    42061 cttgctcatc tatttcagtt aaaccttttt gaataggata agcaacacga atggtacgat
    42121 tatcattacc tatagcgttg ataccaaaag aaaatatgca agaagtgaat atagatgtaa
    42181 ttacaataat taataaaagt aattttttta aattcactac acaatcctcc atatagttaa
    42241 gatttacagt ataaattact gcataaactt gtagacatgt aaaaatagat tagtatataa
    42301 aaggatatat aaatctactt agaaatttaa atatccttaa tatatacaat atatttaaat
    42361 tataactcat ttatatgtct attacaacaa atttaccctg ctaaatacct actctatatc
    42421 ccataatttt acaagttgta gtgaagttta agttctatct cacctcaaat ttagcagtgt
    42481 ttctatttac agttctttta tatttcacat ctggataacc caatataaat gaagtgataa
    42541 ctgcttcgtt ctcgctcatt cctaacagtt cttttatctt tggctctaca tttgatgcca
    42601 taacaaaaaa tccattataa caaattccta atccttgaga ataggccata agttccatat
    42661 tagatgcagc caatcctcca tctacataag cacttccacc tagagacata tcacctacaa
    42721 ctaccataag tagtggggca tcataaaata aagaatcatt tccgttctct ttgtatcttt
    42781 tgtacatttt cttaaatgta tttttataga tagaacgtac agggtcattg tcatcagtat
    42841 ctaatgccaa attataaaga ccttgtattg ccagttcttt cacttctttt agcttttctt
    42901 ttactaatat gtatcttata ggctgtctat taccacctgt tggtgtgtat ctaccagctt
    42961 ccactatgtt ttttattttt tcttcttcta cctctatatc tttatattgt cttatacttc
    43021 ttctaaattt aataaaattc aataactttt cgggttctaa ttcaaaactt tcacgattgt
    43081 attctattac ttcattttta tcaaatcctt gcatttctat tgcatctgtt gggcaaattg
    43141 ccatacagtg accacagtta atacagagaa tatttttaac ctttgcttta tcatccttaa
    43201 cttttattgc atttacaaga cagtctgatt cacacatccc acagcctaca catttttcta
    43261 aatttatgtc tatcattcca aattattcct ccttttaaaa aatttacttt agtataaaac
    43321 aaatagttgt ctaagtcaat ttttattttt ttaacaatat actagcctta actacacttt
    43381 aatggagaaa aatatacata aattggaact taaattagaa cttattcaaa gtaaaagata
    43441 aaagaagtag atgtctaaaa gtgaactttt tagttaatta gatattcttt attgtatgaa
    43501 atcaagtgga tatttatcat ttcaacaata aaaaaggctt acctctattt tggatatgtc
    43561 cctgtcaagt atacagacta aaaaaaggct atctttatgc actgagatag ccccttttcc
    43621 caactactat tgtttatctt aatattagtc aataaattta atttgctata acctgtaagt
    43681 tacattttaa tttgatgtaa ctttaaatta catttttaag taatatcttt aaattatatt
    43741 cttaaaatat atcattaaac tacattttaa ttaatctaaa aactatatct taattaatct
    43801 aagaaactta cattataatc ttttagtttc ccattatcat atacaatctt tgcactaaag
    43861 atatttccag tcttagccca atttaagaac agcctgtcac cttcccacat atttaaatcg
    43921 aatattttat cattatcaac ccaaattaaa tttccttctt tacaatcatt taaatctttt
    43981 tcagataatt caccttcaaa ctcatctgag aaatacaaaa acatatacca atcttcttca
    44041 tctttaaatt ttggaaaagt tatcaaccct ttatatgaca atgatttaag agtaagacca
    44101 gtctcttctt ttacttctct aattacacat tcttctggag tctctccttg ctcaaacttt
    44161 cctccaactc ctacatactt accttcatgt atatcatctt tctttttatt tctgtacaac
    44221 atcaaagtct tgtcatcttt ttctatataa caaatagttg taagtttcat gtatctcgcc
    44281 ttgctttctc ttttatattc tcaactaatt attttcagca ctttcaagca catcacttat
    44341 attcttcatt gcattaagag aaagctctgc aaattcatca aatggaatcc ctatatcttc
    44401 tatacttctc attgcatctc tatttacatt tgaagcaaat ctcgtttctt tcattctttt
    44461 aataacagac ttagtcttta cactggtaag ttttttatct ggataaacta aagctatagc
    44521 agttataaac ccagttatag ggtctgctgc atatattgct ttttccatta ggctagttct
    44581 tgtaactccc attccatcat gatgaccaag tattgctcta tacatttctt cgttaccgaa
    44641 gttttctttt ttaagcagtt ctactgttgt tgtagcatgt ccttcacata tttctcctgg
    44701 ctttcttcca actatatctg aatccaaatc atgtaaaaga cctgccactg cccactcttc
    44761 ttctttttct ggctctagtc ttttggctaa ttctctcata acagcttcaa cagcataaca
    44821 atgttttctc attctatcag tttctaaata cttaaataaa atttctaaag cttcttctct
    44881 cattttcacc aatccccctg ttttttcaca tatatgatat ttttatatat taatacacat
    44941 aaattcaagc ttttatatat attcatgtat atttttcatg ttatatctat tctacacctt
    45001 tatagtagtg tcctgcaact gttccaattt catctaattt cttatacaag tctgtagcct
    45061 tttttccaag tttataatta ttactcagta cctcaatgtg agcttcaata acctttttaa
    45121 ccatctcact atcttcaact gtaaaatcta tcctaaatac atctattcca atttcctcta
    45181 actcatatag attgtccaac atacaagtaa ccttcgaatt gtaaattgta cttctacaga
    45241 atatatcttg tgttatccta taacttgcat ccgtaaagtc tcttaaagca taactacttt
    45301 ccttacattt agcaactctc ttgtcctttt tacaatctct aacaactact cccataggac
    45361 agtattctgt aaccatcata ggagcatatc catatattac tgcttcaatt tctacatctg
    45421 tatattttaa agtttgttta atttcattta agtttagttc ttgtgacaaa caaactgtac
    45481 ttgctccctc ttctttgaag tgatttatac tttcactatt gaatacattt aagtagcaat
    45541 ctatatttaa gtcttttttc ttaaagtatt ccatagagcc ccagttacca atttgaacct
    45601 tattaattcc ttttatatta tccaatatct caaattgctt gtactcttta tttctaacaa
    45661 tccttggtgc tgaatagatt aattttttgt cagtgactgc tgtattagag tggttcttat
    45721 tcaaagtatc tattttactt gtatttgaca aagtatctat gttatttgta tttgaaccca
    45781 ttagttcttt aggagtacct aaagacgaag aagtatctaa atccatagaa atacttgaat
    45841 ctatagaaat atttgaatct atagagatac ttgagaccat ttgtaaagct tttgataatg
    45901 tatttatatc ttcataatag attaaatcta cattataatt taatactgct tctaattgct
    45961 ccaagttctt aactttaact ctaatcttag gagctgtatc aagttttttc tgtttattta
    46021 ctctatttgg ctggtatttt aatctattct tcttaaattt tctatctttt atctttattc
    46081 tttcttcatc taaaagctca atacaatccc ttctcatttg atttaacaca cttataggca
    46141 tacttacacc ttcatccagg tcaatttcta tctcttttaa cttatatggt gtatttccaa
    46201 gcttttgaat ttgtgtttct attttttctt tacttaaagc cacctttata gctttttcaa
    46261 ctattttgtc tccttctacc accgatttat ttccacaaaa atcacttata aaaagctctg
    46321 gctttttacc tagtttaata ctcacttttg cacgtatatt agtttttatg aactctttat
    46381 cttgctgaaa tgtagcttgt actctatcca ttaattcgct gtcagaagtc ttatatataa
    46441 gctgatttct ctttgcttct ccaacaaaat ctaattctat caaatcccct ttatgtgcta
    46501 ttgtagttat ctctccatcc tttattattc ttccaatagt acctccacct aagttaattc
    46561 catcaccttt cttaagcgta ttttctagca ttactctaag tcttttgttc tttctattat
    46621 aatctaaaac ttttccaata tatagccctt gattattagg tctattagag ttcattatat
    46681 ccttaccaac ttcacctaat atatatcctt ttgtaaactt tctattaaat atggtataca
    46741 aattatttat tatttcctca gaaatactta tttttttctt atctacaaat tcattaatcg
    46801 cttctctata tcctgaaacc acagtagcta catactctgg ctttttcatt ctaccttcaa
    46861 tttttaaaga taatacacct gcttcaatta ttttatccaa atcttctata gtacttaaat
    46921 ctctaggact caacaaataa tctccattac tttttactac ttctcctgta tttatatcta
    46981 tcaactcata cttttgtcta catggctgtg cacacctacc tctatttcca gacctattgc
    47041 ctatcatact actcataagg cattgacccg agtaacatac acataaagct ccatgtacaa
    47101 aaacttctat atctacagtt gtattttcac aaatccattt tatctcatca acatttaatt
    47161 ctcttgctaa aacaactcta tcaaacccta cactctgaag gtattttaca tcttctaagg
    47221 aatgtgctac catttgagtg cttgcatgta gttcaaagtc aggtaatagt ttttttataa
    47281 gtcttgccat tcctatatcc tgtactatta aagcatcaat atctatatcg tataaaaatt
    47341 ttacatactc tacaaaatct tctatttcat actgttttat caatgtattt acagtaacaa
    47401 agacttgcac tccccttata tgagagtatt taacagcctc aatcagctca tttctatcaa
    47461 agttatttgc agatgctcta gcactaaagt ctttaccacc taaatacaca gcatttgctc
    47521 cgttttgaac tgctgctttt aatgaatcaa aagagcctac tggtgcaagt aattctattt
    47581 ttttcatatt tttctcctct atttatactt gttaggttaa tataattata tctataactt
    47641 aaatatttgt attaaattta tatatttctt actatatttt aaattcttca atcaatttat
    47701 atattagtta tttatatttg gttcatttga gttaacatat acattattta ctatatttag
    47761 tatatttcta ttaacttata tattgattac tgtattttaa attcttcaat taatttatat
    47821 actgcttact aaatttaaaa cattttaatt aatttgtaca ctgtttacta ta
//
LOCUS       DAEPID010000027        47804 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.027, whole genome shotgun sequence.
ACCESSION   DAEPID010000027 DAEPID010000000
VERSION     DAEPID010000027.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 47804)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 47804)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..47804
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.027"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            complement(167..415)
                     /locus_tag="KR257_001640"
     CDS             complement(167..415)
                     /locus_tag="KR257_001640"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435328.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="VOC family protein"
                     /protein_id="HBH0030345.1"
                     /translation="MQKTKAWGIIEPEKPESQQQMAHMDFAVNDLEEAVQYAIHCGAT
                     IAEEQFTDDWRVMIDPAGHPFCLCQMKSIMESSHFSLL"
     gene            complement(446..907)
                     /locus_tag="KR257_001641"
     CDS             complement(446..907)
                     /locus_tag="KR257_001641"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889914.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glyoxalase/bleomycin resistance/dioxygenase
                     family protein"
                     /protein_id="HBH0030346.1"
                     /translation="MKFGGVLLIVKDINKSKKFYEDVMEQKITLDLGEHVSFENGFGL
                     QSNYKAIIGYDLPIYQQSNNFQLYFEVNDIKQWESKINRIGNIEFLHYIKEYPWGQRT
                     FRFYDFDKNIIEISESMESVIKRLLKQGLALEEISKRTMYPVEFITQFQQL"
     gene            complement(945..1778)
                     /locus_tag="KR257_001642"
     CDS             complement(945..1778)
                     /locus_tag="KR257_001642"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902854.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HBH0030347.1"
                     /translation="MLKKESIHFINKNRSLIVCEDNFVYLLPCIQLRNWISNFTISFP
                     NQTIISDNYTIIPHGSVTLVFFYDATGLHSLLFGPTTKPKTVGNIANRCDVILIIEFQ
                     PAGFFPLIGIQQSELIDKVVPFSIINTSLDLEIKKIFNESLSIDKLILKLEELLISNI
                     KIEYSYEFILAIQLIIQNSGNISSQEISKKVFYSSRHLNRLFNQYLGLSMKSFSRLVR
                     INKSIKLLNNNKTSLMSICNELGFYDIPHFIKDFKIVCGITPQKYRANMSDFYSEIAK
                     F"
     gene            complement(2052..2738)
                     /locus_tag="KR257_001643"
     CDS             complement(2052..2738)
                     /locus_tag="KR257_001643"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729037.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBH0030348.1"
                     /translation="MKITHNSLAVEAKNIIKEYKIGNTTTRVLKEVSLQVMKGEFVSI
                     MGQSGSGKSTLLYILGGLDTPTSGKVYMNGADISHFNDEKMSIIRRRNIGFVFQFYNL
                     IPNLNVEENIMLPLLLDGKNLKDYKNQLDEILDIVGLTDRRKHTPRELSGGQQQRVAI
                     ARALIGKPEILFADEPTGNLDSKTGIEIIDLLNKINRDNGQTIIMVTHSPEAAKSSSR
                     TITVSDGLIV"
     gene            complement(2753..5230)
                     /locus_tag="KR257_001644"
     CDS             complement(2753..5230)
                     /locus_tag="KR257_001644"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902855.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="FtsX-like permease family protein"
                     /protein_id="HBH0030349.1"
                     /translation="MKIILKYIFTNIKERKIRTAVMLLSIVLSTVLLFVSFSIGLSYE
                     SAQRKMAKGMYGTATISVQSKNPDILTNLEDIPDLNAIKSKVGVLESSAIYNKGGYYE
                     EFSLISADLSQLNKINKPRLENGDSITDFSGDKIILPNRFTSKYKIKKGDSITLQIYG
                     KSYTFQVSDIASYDTVFLRNTRGVNALLPKETLSKIINKGSGYTRVLIESEEEITENL
                     VNKLSKELSTEKYMVSNTINETKIISDARQKTMPFFLISFFALTLSIFIIYSSYKVIT
                     LERLPFIGTFRSIGANEKTVTRILMLESILYGSIGGLIAIPIGVVVLNLMLHGLGNSL
                     EQGISIPVVISPIGVIISVIVAIIVSSFSAYIPVKKASHLPIKNIVLGTVEEKNVSNR
                     SILFIGSIMFILSILLPRISPENTLYLAGGFSLLGLIVATIVLIPLITDIMSIVFEFV
                     YKNILGNEGKLAARNMKNNKNIIQNITLLFISISAVIAISVVGNFVKTYITDVFRDAE
                     LQGFADGKMNEEFIEDVRHMDGIKKILPLYVMNNEISGNGVTLSRLEGTDNIKLYNSM
                     FGINYTNFEIKKQVIEAFNDKRSVILNEDTLKKVGLSIGDTITLSNDKYDFSYKIVGS
                     FKSRANDVEAVIPSHYAVNDFDKTNYGFLVYTAVNPDAVMIQIRYLFGDTYNWSRTVE
                     EFNNDSLNTISSFLSPMNKMTYFIFLLATVGIINNLLINYIQKRRSIAMYKSIGLSNK
                     QNIKVTLIEGFTSGLLGAVIGIVISILEIQTIFIVAGPKISMKPDLDFKTFIIVGLLG
                     IIVTLIGSIVPIIKGKKMKLIEEIKFE"
     gene            complement(5449..6852)
                     /locus_tag="KR257_001645"
     CDS             complement(5449..6852)
                     /locus_tag="KR257_001645"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729034.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HAMP domain-containing histidine kinase"
                     /protein_id="HBH0030350.1"
                     /translation="MHKPSYKTVFHSYIIFFMIFICLILTVIGIFLSLITIQKPNGEF
                     IRSDWPKKFTENFNEQIVFIDNKPQVKQSGLEKLRENQLWLQILDSSGNRVYGFLEPK
                     EHKDYYSNSELLALANQNNSSNGTVYFNTIKNNKNDYIYIIYFPLNISKVNMFFDGGK
                     FIGGKSIVFSIIGIIFLIILVSGIAYGYWVTKCISNITSAVSDISKRSYLPVNIKGVF
                     ADIYNSLNILNEEIHRSDEIQNKTDIMREEWISNITHDLKTPLSPIKGYAELLTDSST
                     NYSPEKVYKYASIMLKNIEYTNTLINDLKLTYQLKNGIIPLNKNNYDLVRFLKELSID
                     ILNYPEYESNIVEFKSNIDNINFDFDCTLLKRAFSNLIVNAFTYGDKNTKVCVHITLN
                     ERIEIIISDNGKGMSREEASNLFNRYYRGSNTKQKIEGTGLGLAITKQIIEVHGGNIS
                     VESIPGLGSSFYITFPI"
     gene            7345..8205
                     /locus_tag="KR257_001646"
     CDS             7345..8205
                     /locus_tag="KR257_001646"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435320.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YitT family protein"
                     /protein_id="HBH0030351.1"
                     /translation="MKKQKSPILLEMLGLFFGCISMSIGINMFLKPHTIAPGGLSGLS
                     LVLNKVTGLPVSAIMLIIGVPLVILAFRIMGTKNSLKTLFGTVVFSAIVQLTDPLSKL
                     RFTNDLLLSSIAGGILVGIGLGIMFKSDASTGGTDLIALILSKKFPGIKATKFMSCLD
                     GMVVISSGIVNRSLETALYSGIALCVLIKIADMIMEGFDHSKAFFIISDEPESLRQAI
                     TEELDRGLTILDGKGGYTRENKEVLLVVVSKKQELYLKRLVKRTDPTAFVIVTDVHEV
                     LGEGFKNLEN"
     gene            complement(8444..9001)
                     /locus_tag="KR257_001647"
     CDS             complement(8444..9001)
                     /locus_tag="KR257_001647"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009905633.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HBH0030352.1"
                     /translation="MSDSEYPQMKTLETRNCILRPASLDDVEDFFDCYKNKIVVKHLP
                     FSEHKSLEDTRKFIKSFFLNPYKKGKIGHFAIVYKRDNKVIGNMGFNNINPKALEAEI
                     GICINPSYWGHDFATEITKRVIQYGFRELNLNKIIAITYEENQNSTKSLDLLGFKCTG
                     KYIKKIHTGNTVKNVPCYQYELKKQ"
     gene            complement(9191..10078)
                     /locus_tag="KR257_001648"
     CDS             complement(9191..10078)
                     /locus_tag="KR257_001648"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435316.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LysR family transcriptional regulator"
                     /protein_id="HBH0030353.1"
                     /translation="MNIKLELYKVFNAVVNNKSFSLAAKELFMSQPAVSQSIKQLEEQ
                     LDTLLFYRNNKGVKLTPEGKILSEHVTTALKLISSGEDRINKFKKLEYGSLKIGVGDT
                     AARFFLLKYLEIFHKKYPHIHVSTINRTSRELISLLKDGNIDIAIINMPIEDDTLNIV
                     ECIEIHDIFVCANDYIEYKGRKISLEELNTLPLIMLENKANSRLYVNEYFLSKGIKLN
                     PDIELGSHELLLEFAYINLGVSCVIEEFSIDYLENEKLFKLDIKEPIPKRNIGYCHLK
                     DISLSLATKEFLSMISNNI"
     gene            10197..11396
                     /locus_tag="KR257_001649"
     CDS             10197..11396
                     /locus_tag="KR257_001649"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003493023.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="coenzyme F420-0:L-glutamate ligase"
                     /protein_id="HBH0030354.1"
                     /translation="MDRLVGTVSRGVRAPIIRQGDDLVKIVVDSVLNASKSENFEVRD
                     KDVIAVTEAVVARAQGNYAHVDNIAKDVKDKFGDDTVGVIFPILSRNRFAICLKGIAK
                     GCRKVVLMLSYPSDEVGNHLISIDELDDKGINPWSDVLTEEKYRELFGYNKHTFTGVD
                     YVDYYKNLIKDCGAEVEIVFANNPKTILNYTTSILTCDIHTRQRTKRILRQNGAKKVY
                     SLDDIMTASVDGSGYNDQYGLLGSNKATEETVKLFPINCDEVVNKIQGNIKEITGKDV
                     EVMVYGDGAFKDPVGKIWELADPVVSPAYTKGLEGTPNEVKLKYLADNDFADLSGDEL
                     KEAISKYIVEKDNKSDDLTGNMVSQGTTPRRLTDLIGSLADLTSGSGDKGTPIIYIQG
                     YFDNYTK"
     gene            complement(11590..14145)
                     /locus_tag="KR257_001650"
     CDS             complement(11590..14145)
                     /locus_tag="KR257_001650"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902859.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="FtsX-like permease family protein"
                     /protein_id="HBH0030355.1"
                     /translation="MMSLVKFSIQYIKHYKKQSISIVLSIVLSVALLTGIGSLVHSAD
                     KSRIEKIREDSGDYHYFYKVDKEQLNKIKENKKSKEYTVDRLGVTKPKNQIDEPFIIE
                     FLNADSSYLDMTGRKLLKGTLPSKDGEIVLDTYSLNNLNVNKEIGTEINLDGKIYKLC
                     GILSSLSNPETALEGFVNDYFQPKEKDSYIVYVKYDENKNIKKQNYKFMKKFNISKEK
                     TYINWSLSVEFGVKPPKNIEKYNIFEFLKNLELNTNAIILLVGVFGAAAVYSIFHVSI
                     LQRISQYGVLEVLGANNKQLLFLLFLELFLLFIVGFPIGCFLGIGVASTIYEQFPHIF
                     LSSDIVPGAFFISEKSIYLGFLFILLLLILIAVRVVHQLNKYSSIESMKNFKITNKKK
                     RILESVKHSNMTKVLSHKYMTQKKGMFIGILFSLSLGGIIFLCSSYSIQLTKNNNELT
                     MKADDGLNSDYQITMQTTDFDVGIPKDKISRLNNVEGISKVYPVRYLFGAMQIKEEQL
                     FWKNFFKPLEKDYRIKTFFDGICTKQNEGGYLLKTNIYGYNNGMLEGLNSYIIDGEIN
                     THDMVKNNKVIVRLPMDGTGMYDAVDINPGDTIKVKVPKTMKPTDEIVKFKEENKNDY
                     TTKEFVVAATVKRVMANNIYFIGDYGMDIVMTNGQMKNNFDIENYNSVSIKKTEDSNS
                     EELSENIKSVVSDVKRCIVTDYTIAIEKNNTYLNQKLLFIYGIVFVLLAISLFHIINT
                     VSYLIFSRRHEFGILRAMGITDNKFLLMMIREGFLYGFYASIIMVIGSVIGQFMIYFM
                     VKRVYLYINPILKINTPLYIGMIILNITISIVAVIIPVRQILKSDIISEINKN"
     gene            complement(14142..14828)
                     /locus_tag="KR257_001651"
     CDS             complement(14142..14828)
                     /locus_tag="KR257_001651"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424112.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBH0030356.1"
                     /translation="MSILVTNNLVKHYGKGETKVKALNGVSIEIERDTFTAIVGTSGS
                     GKSTLLNIIGGLDNPTSGDVIIKGKNISKIGKKDLTVFRRRNIGFIFQNYSLMPVLNT
                     YDNIALPVTLDKGNHIDHEYIEMLMKTLGIWDKRLKFPSELSGGQQQRVAIARALANK
                     PALILADEPTGNLDSKTTMEVVCLLKESSAKFHQTILMVTHNENIAQVCDSIIHIEDG
                     VVVNTGGELL"
     gene            complement(14905..15813)
                     /locus_tag="KR257_001652"
     CDS             complement(14905..15813)
                     /locus_tag="KR257_001652"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435311.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HAMP domain-containing histidine kinase"
                     /protein_id="HBH0030357.1"
                     /translation="MFILAFIICTVVIFIVSTRINRKRYDELNLMLNQILEGKEVTYP
                     DTKDTRASKISHQVKKIKDMIEIEVEQSKSEKEAIKGLISNMSHQLKTPLSNITIYCE
                     LLENINISTLQKKEFLQKMKNETFKIDWLLQSLFKMTKLEDGVIEFEVEELLIKDTLI
                     QSISTIFNKAEAKNIRINLEPFSDIKLVHNKKWTIEAIVNVLENAIKYSPSDSTITIS
                     VIKMELYTKITIKDEGIGIDSRELNDIFKRFYRSKNVENQNGTGIGLYLTRLILEKEN
                     GNIIVESKLGSGCCFSIFLQNCKSLN"
     gene            complement(15815..16486)
                     /locus_tag="KR257_001653"
     CDS             complement(15815..16486)
                     /locus_tag="KR257_001653"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889923.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HBH0030358.1"
                     /translation="MNLLIIEDDINLNEGLFYAFENDGFNVFKAYTKQEGLNIFNSKN
                     IDFIILDCNLPDGDGFDVCQIIREKSDIPIIMLTARDSEIDEVKGLEIGLDDYITKPF
                     SLSVLKARVKVAIRKKSNNKVIYSNGIKLDQKLLKVYKNKECLELSSVEYKLLSYLIE
                     NKGQILLKEQILHHIWDSEENYVDDNIVSVNIRRLRVKVEDDPSNPKYIKTAYGMGYL
                     WNEVE"
     gene            16748..17812
                     /locus_tag="KR257_001654"
     CDS             16748..17812
                     /locus_tag="KR257_001654"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902862.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="4Fe-4S ferredoxin"
                     /protein_id="HBH0030359.1"
                     /translation="MKRVDERNTMFARANYKKDSTAYNDYYKKNPDKKEIDDSIRNRP
                     NLCSEGTMTYNELNSPMASSAFDFLSDIKSLCEGKVSDTKVDVDAKSMTKKIKGLAKQ
                     YGASVVGITKLKDYHIYTNRGRHEENYGEEINLTHKYAIVFGCEMDKEMINRAPMICE
                     VIETSKCYVDASIVGMILSYYIRNLGYDARNHMDANYLVMPVFIARDAGLGDIGRNAI
                     LTNKDYGSRLRLGVVTTDIPLLEDEYVDFGLEDFCKVCKKCSFNCPSHSLSNDIKIGD
                     DGKYNWVIEHETCYIKWRYLGTDCGMCISACPFSQNLETIKNTTSFKGNNELIQKALD
                     EYTSKFGKRIFIPGNPSWLK"
     gene            17970..18656
                     /locus_tag="KR257_001655"
     CDS             17970..18656
                     /locus_tag="KR257_001655"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435302.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HBH0030360.1"
                     /translation="MEKILVVEDDSILNKTLSYNLIEDGYIITSKFTAKSALKSIFEC
                     EFDLIILDINLPDKSGFELCNEIKENYNIPIIFLTANDMECDMIKGYELGALDYITKP
                     FNINIFKQKIKAFLNHLTIKTKQDYYKDGYLEINFSELSANINGNQIIFTPLEYRTLK
                     LLTENPKSILTRKVLLEKLWDIDANFVDEHTLTSVISRIRSKIEKDNLKYIKTVYGMG
                     YMWLGERNEF"
     gene            18646..19677
                     /locus_tag="KR257_001656"
     CDS             18646..19677
                     /locus_tag="KR257_001656"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897094.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HAMP domain-containing histidine kinase"
                     /protein_id="HBH0030361.1"
                     /translation="MNFKKFSFSSIYLIIAVGIIFTAILFSISIYLITGDLKLIALLL
                     IYTMVLCGFIALIIFLLHKKIVIFCSKICHTLDSMMNSEDNIEIELEEETILSRINHR
                     LIRMYEVIQENRNSIAIEKADLQELVSDISHQIKTPIANLKMINTTLLNQTFKTEIQK
                     DFLMDMENQLDKLDFLMQSMVKTSRLETGIITLSKKKNSIYETIATALSGILFDAEKK
                     NIEVTVDCDPNLYIIHDKKWTSEAIFNILDNAVKYTSSNGKIRVATECWVMYTKIDII
                     DNGKGISESRQAEIFKRFYREEDVHDIEGIGIGLYLSRKIISLQGGYIKVTSDIGKGS
                     TFSIFLPNK"
     gene            19759..20424
                     /locus_tag="KR257_001657"
     CDS             19759..20424
                     /locus_tag="KR257_001657"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435295.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBH0030362.1"
                     /translation="MSILQVINLKKYYGQSSNITKALDGVTLSIEKGEFISIVGTSGS
                     GKSTLLNMMGGLDNPTSGKVIIKGKELSTMSDEQLTIFRRRNIGFIFQNYNLVPLLNV
                     YENIILPIGLDGETIDKDFINEIINMLSLEEKLYDIPSNLSGGQQQRVAIARALVTKP
                     AIILADEPTGNLDSRTSSDVLSLLKVTSKKFNQTIVMITHNNEIAQLTDRIIRIEDGK
                     IVN"
     gene            20437..22854
                     /locus_tag="KR257_001658"
     CDS             20437..22854
                     /locus_tag="KR257_001658"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861404.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBH0030363.1"
                     /translation="MFRNNNRTFIRKIALNDLKINKLKTYLSGIIIMISTCLLLTVTL
                     VSYNASVDLVNASPYHAIYKSVDEKAKNILYKNKNFSGVGTYKLIGSNKKTDCIMSIV
                     YADDTAIKLMNFQPLKGKLPTNKNEIAISEKYLQEFGLDKDIGDSIKLNYYDDITNKE
                     VQCDFIIVGFLENYYQDNAKQYYTVVSNDYFKNIASTPLQNKSNTFDESRPDTVDVLV
                     KLSEENTEKDSASIKTQLNKIGLSLGIKKYNIYLNDNYIESNLIDGEQIITVLVVGIV
                     VLFSSVFVIYSIFYISVVNSVQMYAKLKSLGMTSFQLKKIISLQGNILSIIFIPLGVI
                     ASCIIAYIIQPLAWQMIADLFIILILSLVMFLTVRISLFKPARIISKISAIEAMQYTE
                     TKFRKKAKNFSYINIKNLALKNIESNRKKNLIALISLSISGVLFISIANLANSIDFKK
                     QLSQQFVYNEDYIISIKSDNLYEHITEIQQNNPLTDSLKNEIKSIHGVKKLIESKSIK
                     SNIIEPYIKDRDEKQFITLIKGITPELSKSLEEYIVSGKIDYTHLDSDSLIINKYRTK
                     YYGLNLKVGDTVTFNIFSGNDIIKKKMKIIGIIDNSNTGGMFFASDKTLESLTPYNTN
                     LDFSILIDKKHSKEVEEKLLSIIQKNSNLMLYSYEDDYRMITRAFQYIIIASYIFVGL
                     ISCFGILNMTNTLINSVLIRKKEFALLQAVGMTRKQLRNMLYREGLNISIKAICTSST
                     LGYFGSNLLCTFIKDVIRLDFINFKFSIFTILIFSFVLIGIQVLVTELLVRNIEKKSL
                     TERLRSQ"
     gene            complement(23035..23826)
                     /locus_tag="KR257_001659"
     CDS             complement(23035..23826)
                     /locus_tag="KR257_001659"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424121.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="HBH0030364.1"
                     /translation="METKQYLIDFYNTYDEDSRLALKHGMVEFLTTMHYIDKYIKSGD
                     CVLEIGAATGRYSHTLARQGYDVDAVELVEHNIEVFHKNTQSNENISITQGNAMDLSV
                     FPDNKYDITLLLGPLYHLYNKEDKQQALHEAIRVTKPGGVVFAAYVISDGCLIDEGFH
                     RGNINVSEYIEKGLIDPQTFAAKSEPKDLFELVRKENIDDLMSAFNVTRLHYVASDGL
                     ALYMREAVDSMDDDAFALYLKYHLATCEREDLVGVTSHAIDIFRK"
     gene            complement(23859..24446)
                     /locus_tag="KR257_001660"
     CDS             complement(23859..24446)
                     /locus_tag="KR257_001660"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729026.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="HBH0030365.1"
                     /translation="MPPKVKITKEMILNTVLDITREVGFEAVNARSIASKLQCSTRPI
                     FTCYENMNELKNEFLAFAYEYYNQYVVNYSNSKSVSPYLLLPLSYIEFAQEETHLFKL
                     LFINDLDLMMEEANDFYKEIDNEKKARLFSESIGIELECAKVIFLDLFLYTHGIAVLT
                     ATKKLTLDRYSAEKMLKNILTAFIRQEKPDWNLSI"
     gene            complement(24623..26014)
                     /locus_tag="KR257_001661"
     CDS             complement(24623..26014)
                     /locus_tag="KR257_001661"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889936.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="benzoate/H(+) symporter BenE family transporter"
                     /protein_id="HBH0030366.1"
                     /translation="MERLARREQPHIKFGMFKIRIPFIHYRFEKPEAIQGIISSMTSL
                     GTIGLSTQILGLPYEVAWSMAIINSILYCLHVFMGDPVVPGWITASITLTTAYLLKFS
                     MGIERIQALTALQIDLGIIFILMGITGVAGKLVSKIPNSIKGGILMGVGISTIISEFN
                     PKGRFDSYPISITVGILVACFVMFSERFDTLKVKNKFLFHLGEYGVVSAILVSLIVGI
                     FSKEIEIPRFSFDNLVYIVDFKNLINTVSPFGIGFPSVMLFIQGIPMAFMIYIIAFGD
                     FITGENLVLSESENRKDEYIDFNSNRSNVISGIRNIFMAIFSPYIPMCGPLAATLTGS
                     VAQRYKVGKEAMQSVFSGMGTLVWVSAIFICFYPIAQIATPLIPLALSVTLLVQGYLC
                     TKLSMELCNTGVEKGLIGLMGGVIAAKGGTWGLAVGFILYFILIDSKKRKEKDINSIE
                     DCVYEILDKKKSI"
     gene            complement(26204..27502)
                     /locus_tag="KR257_001662"
     CDS             complement(26204..27502)
                     /locus_tag="KR257_001662"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428762.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="acyl-CoA thioesterase/BAAT N-terminal
                     domain-containing protein"
                     /protein_id="HBH0030367.1"
                     /translation="MKVNVYNVESFVDERLKIMVSDLIPNTKLKISVKMEFPWCKGEE
                     FSSYGVFCSNEKGEVDLDLVEPIEGTYKADNCMGLIYSLEKSKTEGKNFAENISIDKP
                     IIMNMIFETSIERKEVELKRIFKSEDITTKYISDEFIGKLFYKQNSNNKTILMLGGSD
                     GNLDALDLLAAPLASRGFNVLTVAYFALEGLPDKLEEVPLEYFEKVFEWISENEITST
                     KEIFVHGTSKGGELAFLLASRYEQIKKVVVSQPHIYCFQALNGLMSGNDTSSWSYKGE
                     PFPYIKVDNDIFFEEQKKNISKDIPFGFNSTYKKSLKRAENRKEARIKIENSKADILM
                     IAGKEDNIWNSYEACLEALEIFEENNYPYNVELLTYNNMGYPLPIPYIMPLKETLCMS
                     MSRGIFSSGGTVEGNSKGQFESWNRTIEFYKKPLSSDLNN"
     gene            complement(27859..28734)
                     /locus_tag="KR257_001663"
     CDS             complement(27859..28734)
                     /locus_tag="KR257_001663"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861406.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="kinase"
                     /protein_id="HBH0030368.1"
                     /translation="MITFDVNGAIIRFDDTKNNYNKIRKIFKLYALEISKNFERDCLN
                     SFQNLKQISDRGLSLGEKYIEESFKKGIETIVSFGIITIDIDTFKSVYCEKYLDFKRL
                     FNNLNKTFIIPNKNKKNGHASFLEIESTIKKMSNYLYNDCFKIHYAVVDALIENRITA
                     VHSYIDEESIKKSNALFNNYKDGFIGKADECKVVKQIITLNPYREDVYEFLVKEDGDF
                     SKEIERLTEFLGYDIREYKASLMDIYINELMESDENDVENAKEKIEKYARYIGCSDEN
                     LYVARVNAIYTFANA"
     gene            complement(28927..29613)
                     /locus_tag="KR257_001664"
     CDS             complement(28927..29613)
                     /locus_tag="KR257_001664"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428767.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF554 domain-containing protein"
                     /protein_id="HBH0030369.1"
                     /translation="MFGVIANSLAIAGGCIVGLIIKGGLPQRVSDTIMNGIALCVLYI
                     GISGALEGKNTLVTIISVAVGALIGELIDIDKWVNKLGAFLQSKFSKGNKKDSIAEGF
                     ISSSLLFCIGAMAVVGSLESGLTGSHDTLFVKSVIDGIASIIFTASLGIGVMFSAISV
                     FLYEGIICVGASFLNGFLSDPVVTEMTAAGSLLIIGLGLNVLKLTNIKVANLLPAIFI
                     PILFGVFGII"
     gene            complement(29662..30195)
                     /locus_tag="KR257_001665"
     CDS             complement(29662..30195)
                     /locus_tag="KR257_001665"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003433028.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="prolyl-tRNA synthetase associated
                     domain-containing protein"
                     /protein_id="HBH0030370.1"
                     /translation="MSDLNNKKEQDENESSMNETKIYDILDKLNVEYDVVEHEAVYTA
                     EQLVILDGITKGCQCKNLFLRNAKGNKYYLIVVKGEKQVDLNSLKDKIGSSRLSFASP
                     ERLYNVLKLLPGSVNPFSLINDTERKVELYIDKDVIKEDYLNFHPNINTKTVNISRKG
                     FEEFLEYLKYPIQSIDV"
     gene            complement(30239..30871)
                     /locus_tag="KR257_001666"
     CDS             complement(30239..30871)
                     /locus_tag="KR257_001666"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428771.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cyclase family protein"
                     /protein_id="HBH0030371.1"
                     /translation="MKVFDLTHVTHNDMPVYAEPNRPDIKKVAIIEENGYQETLISVF
                     SHNGTHMDSPRHMYTKGETLDKLDIENFVGKAYVLELEKGNENIELEYLKKYEDEIKN
                     SDFIIFKSGWSKFWDKKQYYVGYPTLTKEAANYIANTNIKGIGIDMLSVDRYDTSVFE
                     VHHILFEKGKIIIENLTNLENVPEKFLFIAAPFKYNDADGAPVRAIAIVE"
     gene            complement(30961..32040)
                     /locus_tag="KR257_001667"
     CDS             complement(30961..32040)
                     /locus_tag="KR257_001667"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435274.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SIR2 family protein"
                     /protein_id="HBH0030372.1"
                     /translation="MKIAIFLGAGASAAENLPIQNELFSEYFKKLNPTNYNTKMNREL
                     YIFFKQMFNIDIVKDNIDNANFPTFEEVLGLLDLAEQRKEAFRNFGLENLNNRSDSIR
                     FLRQYLILLMAEAIHNTPRTDNKYHKLLVENLLENDLLLDTTFISANYDIHIDNTVTG
                     LRDKNDLPIMLDYGVEFTNFKEELNWRKPKEPLIKLYKIHGSLNWLYCPICNSVTLTP
                     HEGGVMKLIENSSETKCLECGELTEPIIVPPTYFKNMSNIFLSNVWNETEKTLRDTDL
                     LIFCGYSFPEADMHIKYMLKRVQTNRKKPPLKIMVFNNHSQKQRITLKKEEGRYKRFL
                     GEDVIFTDNSFQDFSVNPLRFIKNI"
     gene            complement(32173..33519)
                     /gene="pepV"
                     /locus_tag="KR257_001668"
     CDS             complement(32173..33519)
                     /gene="pepV"
                     /locus_tag="KR257_001668"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861407.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dipeptidase PepV"
                     /protein_id="HBH0030373.1"
                     /translation="MKEQIKEKVNSLQDEMISSIQESVKIPSVISEATENCPFGENVD
                     KALRGILDLCKSLGFKTVYKDGYYGYAEIGQGEKMIGILGHVDVVPEGDLESWNYPPF
                     EAVLEDGKLYGRGTQDDKGPTISAIYAVKALMDLNVDFNKRIRFIFGADEENLWRCIN
                     KYKENNEEIPNYGFTPDSRFPITNAEKGLLQVHLTCDSKSDIELSVGKALNAVPGKAI
                     YIGKYSDKLKKELDKLNFEYTVEGNKICIIGKSVHSAASDTGINAVARLCIALNNIGI
                     DSNIIKFLAEVIGEDANGNNIIPNCKDDVSGKLTVNIGRVTIDNEKEFAGIDVRIPVT
                     YKKDDFVKELKKMTDKYNLNYEEYDFLDSIYVPEDTLLVKTLRKVYEEETGLDGTPLS
                     SGGATYARALDNCVAFGAIFPGKPETEHQANEYLIVEDIIKATQIYALSIYELLKI"
     gene            complement(33588..34868)
                     /locus_tag="KR257_001669"
     CDS             complement(33588..34868)
                     /locus_tag="KR257_001669"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428777.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="methionine gamma-lyase family protein"
                     /protein_id="HBH0030374.1"
                     /translation="MLNETKELLKDYYGIDDDTFKLSQEIMEEIKDKFEEIKEIREYN
                     QYKVLKAMQESKLSDMHFNWTTGYGYNDIGREKIEEIYSKVFNTEDALVRPIIVNGTH
                     ALTLCIQGIVRPGDEILSVTGRPYDTLEGVIGIREEKGSLKEYGVTYDDVDFLEDGNL
                     DLEGIKNKINDRTKLVMIQRSKGYSWRKSLSISDIKEAIEVIKSVKPEAIVMVDNCYG
                     EFLDTKEPTDVGADVMAGSLIKNPGGGLALTGGYIAGRKDLIELISYRMTSPGIGKEC
                     GLTFGTTRNVLQGFFLAPYIVSQAVMGAIFCSRAFEKLGYDVLPKYDDLRSDIIQCIR
                     LNNADEVISFCEGIQEAAPVDSYVKPVPWDMPGYESEVIMAAGAFIQGSSIELSADAP
                     IRPPYNVYFQGGLTFDHSKMGTLKAIEFIKKLKK"
     gene            complement(34995..35255)
                     /gene="hfq"
                     /locus_tag="KR257_001670"
     CDS             complement(34995..35255)
                     /gene="hfq"
                     /locus_tag="KR257_001670"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428780.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RNA chaperone Hfq"
                     /protein_id="HBH0030375.1"
                     /translation="MKNTVLNLQDLFLNNARKERIPVTIYLVNGVQVKGLVKGFDSYI
                     ILIEGDNRQQNMIYKHAVSTIQPGKYINLTNQNQNNNNNNNR"
     gene            complement(35369..36304)
                     /gene="miaA"
                     /locus_tag="KR257_001671"
     CDS             complement(35369..36304)
                     /gene="miaA"
                     /locus_tag="KR257_001671"
                     /EC_number="2.5.1.75"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861408.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA (adenosine(37)-N6)-dimethylallyltransferase
                     MiaA"
                     /protein_id="HBH0030376.1"
                     /translation="MKKIPLIILTGPTAVGKTDLSIKLAKDMNAEIISADSMQIYEYM
                     DIGSAKVTEEEMQGVKHYLIDEVKPDYPFSVSEFQQRAKKYIHEINEKEKCVLVTGGT
                     GLYLNSLIYNMDFAQSDANNELREELQKQLAEKGIDYMHNKLKELDEESANRIHKNNT
                     KRVIRALEVCLSGKKMNDFSSDLKFNEEYQPIIIVLNRDREHLYQRINMRVDIMIKNG
                     LVEEAKKLLSMGFKKDMISMQGIGYKEILKYLDGEYTYEEAIEIIKRDSRRYAKRQIT
                     WFKRYKTAKWFDLDQYENIDELKNEIILYIKDSIK"
     gene            complement(36342..38309)
                     /gene="mutL"
                     /locus_tag="KR257_001672"
     CDS             complement(36342..38309)
                     /gene="mutL"
                     /locus_tag="KR257_001672"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729024.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA mismatch repair endonuclease MutL"
                     /protein_id="HBH0030377.1"
                     /translation="MKNIINILDDLTINKIAAGEVVERPSSVVKELIENSIDAGANKI
                     SIDIIDGGKSLIKITDNGIGIPSSEVEKSFLRHATSKIKKIDDLYDLYSLGFRGEALA
                     SISAVSKLEMTTKTKDEIIGTKIYVEGGKIISKEPIGSTNGTTIIIKDIFFNTPARQK
                     FLKSTHAETINISDLINKLAIGNPNIQFKYTNNNKQMLNTPGDGKLVNTIRSIYGKEI
                     TENIIDVEFKCNHFKMNGYIGNNNIYRSNKNLQHIYINKRFVKSKIIIDAITESYKSI
                     IPIGKHAVCFLNIEVDPSCIDVNIHPNKLEIKFEKEQEVYIELRDFLKVKLIHSNLIG
                     KYATYSDKKTQPRIAINSREKSTDYKLRNNDLLESTPKNSNITKGKDEVIEVVTLSSE
                     KPINEFQSVSEVLNASVEDDVKNINYLSEDSANDNIQEEFQVDGIKNEGNYYLGDSIK
                     DSEEEYLCSSKRKFSLYGYFVIGVVFNTYIILSKDDSMYLLDQHAAHERILYERYMEK
                     FYRQDINMQILLDPVVIEVSNIDMLQIENNLELFMKFGFELEIFGNNHIMVRCVPTIF
                     GVPETEKFILQIIDNIEEITSNYDLKGERFASMACRSAIKANDKIYDIEIKSLLEQLE
                     KCENPFTCPHGRPIMVEISKTEIEKMFKRIM"
     gene            complement(38320..41163)
                     /gene="mutS"
                     /locus_tag="KR257_001673"
     CDS             complement(38320..41163)
                     /gene="mutS"
                     /locus_tag="KR257_001673"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435264.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA mismatch repair protein MutS"
                     /protein_id="HBH0030378.1"
                     /translation="MQIDMNKLTPMMKQYLEVKNRYKDCILFFRLGDFYEMFFEDALV
                     ASKALEIALTGKACGLEERAPMCGVPFHSANSYISKLVENGYKVAIGEQMEDPSTAKG
                     IVRREVIRVITPGTVLDGNLLENKKNNYLLSLYKDGTNIGLTYVDISTGETNATCLNE
                     DKVIEEIAKIHPTEIIINDLDFIEKLRDIATVSNIYINESFSDNYLDINILKEYFPDV
                     YLQKLKFDDKGLIKSSLSILLNYIYNTQKQITSNINNINIYNSSEYMVLDMFTRTNLE
                     LTQTIRGNKKKGSLLHVLDKTSTAMGGRLLRKYVEEPLINKSKIENRLDVIEEIKDDF
                     ILREDLNDILKNIYDIERICGKIAFERVTPKELIHLKNSIEKLPNLKDTINLSNAKIL
                     KEYVSEMDKLDDIYNLIDEAILEEPTITIKDGNIIKSDFSDELKELREISKNGAFLVK
                     EIENREREKTGVKSLKIGFNKVFGYYIEITKANFKQAKLDETYIRKQTLSNAERYITP
                     ELKEIEEKILHAEEKIKSLEYEIFVEIRDTIYKNIDRIQKVAKTIANIDVFVSLATVA
                     HINNYVKPAINENNKLDIRNGRHPVVENIVGEENFVPNDTYLNRGENIINIITGPNMS
                     GKSTYMRQTAIIALMAHIGSFVPAESADIPILDRIFTRVGASDDLSQGQSTFMVEMNE
                     VSLILKNATERSLVILDEIGRGTSTYDGISLAWSIVEYIQKNIRCKTLFATHYHELTD
                     LEEEFKEVKNYSIAVKEDGEGIIFLRKIIPQGADKSYGIYVAKLAKLPDEVIERAKYI
                     LKDLEKNHVYNSVAINGDKENNNIINSNLDEELVKVNQSNFKNKYESLKIEHELIVKD
                     YKHIKKDYDKLNSKFKALNDEVALMKQNDDKEKINQEDSVKEVALTQISFDSVNRDIL
                     SEEILNLDILNMTPLDAINSLYNLQRKAKEIKS"
     gene            complement(41324..42058)
                     /locus_tag="KR257_001674"
     CDS             complement(41324..42058)
                     /locus_tag="KR257_001674"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428791.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBH0030379.1"
                     /translation="MLTQMNFYHNKKVKVSIENVSKTYKDIEVLKDISIDVYEGEFVS
                     ILGPSGCGKSTIFNIITKLTDYDSGKVNINGKYSYMYQKDLLLPYKTIIDNVSLPLIL
                     KKEKKSKARSMVKPYFEVFGLSGYEDKYPSELSGGMRQRANFLRTFINSNDIMLLDEP
                     FGALDSLTKTSMQKWLLDVKKKVNSTILLITHDIDEAIMLSNRIYVISKKPSIVKKEF
                     VIDSRKLNEDNLENIIKLKKEIISLL"
     gene            complement(42027..43040)
                     /locus_tag="KR257_001675"
     CDS             complement(42027..43040)
                     /locus_tag="KR257_001675"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861411.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="HBH0030380.1"
                     /translation="MNFKKLGILGLVSVFTLATITGCSSNNNKDKNNDKDTSSKKVTM
                     VLDWTPNTNHTGLFVALDKGYYKEEGLDVEIVQPPESGAETLVATGKADFGISYQEQV
                     TYAKTSEDPLPIKAVATVIQHNTSGFASPKEKNITTAKDFEGKTYGGWGSPSEEAVFK
                     AVMKKNGADFNKLKIVNTGQDDFFAAMKTVDFAWIFEGWDAVKADLIGYDLNFIPVKD
                     LDERLDYYTPLIISNETVLKNNPELAKKFLKATTKGYEYAIKNPEESAKILVKHAPEV
                     DEKLALKSQEYLASKYKDDAPRWGEMKDSVWNNYTSFLKEYKLIDKDMKASDAYTNEF
                     LPQ"
     gene            complement(43062..43832)
                     /locus_tag="KR257_001676"
     CDS             complement(43062..43832)
                     /locus_tag="KR257_001676"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435260.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBH0030381.1"
                     /translation="MKNLEIIDKVKDSIYPIATFLFILILWQSMVGVLEVPQYILPTP
                     VDIINVFFKDYQNLSIHAVVTIGEAILGFIVAIIISLVIGILMDFVSIIKKCLYPIML
                     VTQMIPTIIIAPLFMIWFGFGTMPKVLMVMLTCFFPILISFVDGIENIDKDYLNLFKT
                     MDSNKVNTFIHLKFPMAMDKFFSGLKISATYAVMAATVAEWLGGTKGLGVYMLRSKSA
                     YALDKVFASTILVVIFSLMFVGIVQAVKKVVIRHRLID"
     gene            complement(43807..44097)
                     /locus_tag="KR257_001677"
     CDS             complement(43807..44097)
                     /locus_tag="KR257_001677"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424145.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MTH1187 family thiamine-binding protein"
                     /protein_id="HBH0030382.1"
                     /translation="MVIADIAVMPLRPYKGEEEMYKVVDACIAEIEKSGLKCEIGAMS
                     TTVEGDFDEVFELLKKVHKIPFNLGCERVITVARVDEKAGGLTIDEKLRNHR"
     regulatory      complement(44228..44327)
                     /regulatory_class="riboswitch"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00059"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="TPP riboswitch; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /bound_moiety="thiamine pyrophosphate"
                     /db_xref="RFAM:RF00059"
     regulatory      44947..45036
                     /regulatory_class="riboswitch"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF01051"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="cyclic di-GMP riboswitch class I; Derived by
                     automated computational analysis using gene prediction
                     method: cmsearch."
                     /bound_moiety="cyclic di-GMP"
                     /db_xref="RFAM:RF01051"
     gene            45089..45265
                     /locus_tag="KR257_001678"
     CDS             45089..45265
                     /locus_tag="KR257_001678"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729350.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0030383.1"
                     /translation="MFMDKMDRCTHILTAYICSSRDYCNFIDTQLNDFILEYGENVVE
                     SCLHQVMVLVSRYN"
     gene            complement(45380..45736)
                     /locus_tag="KR257_001679"
     CDS             complement(45380..45736)
                     /locus_tag="KR257_001679"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428797.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HBH0030384.1"
                     /translation="MDIDNNFEEFPNIEERQKDFNCSIGFTMTVIGSKWRAIILWHIL
                     KQEPIRYSQLKKEVVHISHKILSQELKYLERDGLIKRISYPTIPPKVEYLSTKRGKSL
                     ESILLELCNWGKQYMR"
     gene            45992..46905
                     /locus_tag="KR257_001680"
                     /pseudo
     CDS             45992..46905
                     /locus_tag="KR257_001680"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007061260.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="PhzF family isomerase"
     gene            47136..47747
                     /locus_tag="KR257_001681"
     CDS             47136..47747
                     /locus_tag="KR257_001681"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893378.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CoA pyrophosphatase"
                     /protein_id="HBH0030385.1"
                     /translation="MINDIKNKFKNYKPYINGYKNMKRASVLIPIVEINNTHYILFEV
                     RSKNLKHQPSEISFPGGKIESGETPYEAVIRETCEELGTFSDNIEVISSLDLLITPVK
                     FIIHPYLGYIKNINNLNINKDEVDHTFLVPIKYLLENPPNTYSNTVKVFPDENLPYGS
                     IPNQKDYKFESGSYPILFYKYKDYVIWGMTAKILENFLNFLSE"
BASE COUNT        16434 a         7389 c         5493 g        18488 t
ORIGIN      
        1 taaaatatct aagaaattat tcaataaaaa aatactattt tttaaaaatt atcattattg
       61 ataaagctct actatttata ttttttagtg tattcatgta taataagtaa aagcacaacg
      121 gtatatactg ttgtgctttt ttgtaattaa taaacaatat tttggtctat aacaatgaaa
      181 aatggctact ttccataatt gatttcatct gacataagca aaaagggtgt ccagctgggt
      241 caatcataac tctccagtca tcagtaaatt gctcctctgc gattgtagct ccacaatgaa
      301 ttgcatattg aactgcttct tctaaatcat taacagcgaa atccatatga gccatttgct
      361 gttgagattc aggtttttct ggttctatta tgccccaagc ctttgttttt tgcaatataa
      421 agaaaaaatt atatatttta atattttata attgttgaaa ttgtgtaata aattcaactg
      481 gatacatagt gcgttttgaa atttcttcta aagctaaacc ttgttttaaa agcctcttta
      541 tgacgctttc catactttct gaaatttcta taatattttt atcaaaatca taaaacctaa
      601 aagttctttg accccatggg tattctttta tataatgcaa aaattcaata tttcctattc
      661 tatttatctt actttcccat tgtttgatgt cattaacctc aaaatacaac tgaaagttat
      721 ttgattgttg atatattggt aaatcatatc caattatagc tttataatta ctttgtaatc
      781 caaatccatt ttcaaatgat acatgttctc ctaaatctaa tgtgattttt tgctccataa
      841 catcttcata aaactttttt gatttattta tgtctttgac aattagcaat actcctccaa
      901 atttcatctt atcactatcc tttctttgtt ataagtatta taacttaaaa ttttgcaatt
      961 tcactgtaaa aatcagacat attagctcgg tatttttgag gagttattcc acagacaatt
     1021 ttaaaatctt taataaaatg tggtatatca tagaatccta attcattaca tatagacatc
     1081 aatgaagttt tattattgtt tagaagtttt atagatttat taatacgtac caaacgagaa
     1141 aatgacttca tactcaaccc taggtactga ttaaagagtc tgtttaaatg cctagaacta
     1201 taaaatactt ttttagaaat ttcttgtgaa gatatatttc cagagttttg aataatcaac
     1261 tgaattgcca aaataaactc atatgagtat tcaattttaa tattagaaat caataattct
     1321 tccaacttta aaatcaattt atctatagat aaagattcat taaatatttt tttaatttct
     1381 aaatctaatg aagtattaat tatagaaaat ggaacaactt tatcaataag ttcactttgc
     1441 tgtataccta taagcgggaa aaaaccagca ggttgaaatt ctataattag tataacatca
     1501 catctattag caatatttcc tactgttttt ggtttagtag ttggaccaaa taatagacta
     1561 tgtaaccctg tggcatcata aaaaaacacc aaagttacac ttccatgagg aataatcgtg
     1621 taattatcag aaattattgt ttgatttgga aacgatatag taaaattcga tatccaattt
     1681 cttaattgta tacaaggcaa gagataaaca aaattgtctt cacaaactat aagtgaccta
     1741 tttttattta taaaatgaat actttctttt tttaacatat attatatcct gtcctatcgt
     1801 gaatatttat taaagtaaga agaatccata ttatctctat atatcattaa ctgcttttaa
     1861 taatagagat agtatgaata ctcattagat atttaataaa caaataaaat taaaataatc
     1921 aataaaaaat atagtacttt tatctgttat tttaatatta tagcacattt atagtattta
     1981 acttatatcc actttacata tgtctaattt atataattaa aaatgcttat ctcaaataca
     2041 ataattagtc cttatacaat taaaccatct gaaactgtaa tagtacgact actacttttg
     2101 gctgcttctg gtgagtgagt taccataatt atagtttgtc cattgtctct gtttatttta
     2161 ttcagtaaat ctattatttc tatccctgtt ttactatcta aatttccagt aggctcatca
     2221 gcaaatagaa tctctggttt tccaattaaa gctcgagcta tagcaacacg ttgttgctga
     2281 ccaccagata actctcgtgg tgtatgttta cgtctatcag ttaaaccaac tatatctaag
     2341 atttcatcta attgattttt ataatctttt aaatttttac catctaataa caaaggaagc
     2401 attatatttt cctccacatt taaatttggt attaagttat aaaattgaaa tacgaatcct
     2461 atatttctac gacgtattat gctcattttc tcatcattaa aatgtgatat atcagctcca
     2521 ttcatataca cttttccgct cgttggagta tctaaaccac ctaaaatata taaaagagta
     2581 cttttgccag aaccagattg acccatgata gaaacaaatt cacctttcat tacttgtaaa
     2641 gatacctctt ttaacactcg agttgttgta tttccaattt tatattcttt gataatattt
     2701 tttgcttcta cagctaaact attatgtgta attttcatat taacctccat aattattcaa
     2761 acttaatttc ttctatcagt ttcattttct tcccttttat aataggcact atcgaaccta
     2821 ttaaagttac tataattccc aataacccaa caataataaa tgttttaaaa tctaaatctg
     2881 gtttcattga aatttttggt cctgcaacta taaagatagt ttgaatctca agtatagata
     2941 tcacaatacc aataacagct ccaagtaaac ctgaagtaaa cccttcaatc aatgtcactt
     3001 ttatattttg tttattactt agtcctatag atttatacat agctatagaa cgtctttttt
     3061 gaatataatt aatcagtaga ttattaataa tacctactgt agcaagaaga aaaatgaaat
     3121 aggtcatctt attcatagga gacaaaaaac tacttatagt atttaaagaa tcattattaa
     3181 attcttcaac tgtacgactc caattatatg tatctccaaa taaatatctt atctgaatca
     3241 taacagcatc tggattgact gctgtatata ctaaaaaacc ataattagtt ttatcaaaat
     3301 cattaactgc ataatgtgat ggtataacag cttctacatc atttgcgcgg gatttaaaac
     3361 tacctactat tttataagaa aaatcatact tatcattaga tagagttatt gtatctccta
     3421 tagataagcc tacttttttt agagtatctt cattcaaaat aacagaacgt ttatcattaa
     3481 aagcttctat tacttgtttt tttatctcaa aatttgtata attgattcca aacatagagt
     3541 tatatagttt tatattatct gtaccctcta gtcttgataa tgttacacca ttaccagaaa
     3601 tctcattatt cataacataa agaggtaata tttttttaat tccatccata tgtctaacat
     3661 cttcaataaa ctcttcattc atctttccat ctgcaaaacc ttgtaattct gcgtcacgaa
     3721 acacatctgt tatataagtt ttgacaaagt taccaacaac acttattgca ataactgcag
     3781 aaatacttat aaatagtaaa gtgatattct gtattatatt tttgttattt ttcatatttc
     3841 tagcagctaa tttaccctca ttccctaaaa tatttttata aacaaactca aaaactatag
     3901 acatgatatc agtaataaga ggaatcaaca caatagtagc tacaattaat cccagtaatg
     3961 aaaatccacc agctagatac aatgtatttt caggggatat tcttggaagt aaaatagata
     4021 aaataaacat tatacttcct ataaaaagta tagaacgatt tgaaacattc ttttcttcta
     4081 ctgttcctag tacaatattt tttatcggca aatggctagc ttttttaaca ggtatatatg
     4141 cactaaatga agaaacgatt attgctacta taacagatat aatcactcca atgggtgata
     4201 ttactactgg aattgatatt ccttgttcga gagaatttcc taacccatga agcattaaat
     4261 ttaaaacaac tacaccaata ggaatagcaa ttaatcctcc tatacttccg tataatatac
     4321 tttcaagcat caatatacga gttacagttt tttcattggc accaatactt ctaaatgttc
     4381 caataaaagg aagacgttct aatgtaataa ccttataact gctgtatatt ataaatatac
     4441 taagggttaa tgcaaaaaaa cttattaaaa agaaaggcat tgtcttttgt ctagcatctg
     4501 aaattatctt agtttcattt atagtatttg ataccatata tttttcagta gaaagttctt
     4561 tggataattt atttactaga ttttctgtaa tttcttcttc tgactctata agaactcttg
     4621 tatatccact gcctttattt ataatttttg atagagtctc tttgggtagc agtgcattta
     4681 cacctcttgt gttcctcaaa aatactgtat cataagatgc aatatcacta acttgaaaag
     4741 tataagactt tccataaatc tgcaaagtaa tagaatcacc tttttttatt ttatattttg
     4801 atgtaaagcg atttggaaga ataattttat caccagaaaa atcagtaata ctatcgccat
     4861 tttctaatcg tggcttgttg attttattta gttgacttaa gtctgctgat ataagactaa
     4921 attcttcata gtatccccct ttattataaa tagcagagct ttccaataca ccaacctttg
     4981 attttatagc atttaaatca ggtatgtctt ctaaattggt taatatatct ggatttttac
     5041 tttggacaga tatagtcgct gtaccataca taccttttgc catttttctt tgtgcacttt
     5101 cataagataa tccaattgag aatgaaacaa aaagtaaaac tgttgataaa actatggaca
     5161 ataacataac tgctgttcta atttttcgtt ctttaatatt tgtgaaaata tactttaata
     5221 taattttcaa atttacacct tctttcctta tctaagatat ttcaatctaa tatttttata
     5281 ctttaatcta aattaaatct ctaatagact cctccatact tttatcattc tatttataat
     5341 atttttaatc aaatcacccc ttaaataaaa aagattgata aactactata taaatataat
     5401 aatctatcaa ccttaatata ttttttattt gaccttaatt aaccttaatt aaataggaaa
     5461 ggtgatataa aatgagctac ctaatccagg tatactttca acagatatat tccctccatg
     5521 aacttcaata atttgcttcg ttattgctag tcctaaacca gttccttcta ttttttgttt
     5581 tgtattgctt cctctataat aacgattaaa caaatttgat gcttcttctc ttgacatccc
     5641 ttttccatta tcagatataa tgatttcaat tctttcattt aatgttatat gtacacaaac
     5701 tttagtattt ttatctccat atgtaaaagc attgacaata agattactaa aagctcgttt
     5761 taatagtgta caatcaaaat caaagttaat attatctata ttactcttaa attcaactat
     5821 atttgattca tattctggat agtttaaaat atcaatggat aattctttca aaaatcttac
     5881 taaatcataa ttatttttat ttaaagggat tattccattt tttaattgat aggttaattt
     5941 taaatcgttt ataagtgtat ttgtatattc tatattcttt aacatgattg aagcatattt
     6001 atatactttt tcaggtgaat aattagtact actatctgta agaagctctg catacccttt
     6061 tattggtgaa agtggagttt ttaaatcatg agttatattt gaaatccact cttctctcat
     6121 aatatcagtt ttattttgta tctcatcact tctatgaatt tcttcattta aaatatttaa
     6181 actattatat atatcagcaa aaacaccttt aatattaact ggaagatagc ttcgttttga
     6241 aatatcgcta acagcagatg taatatttga tatgcacttt gttacccagt aaccataagc
     6301 aattccagaa accaaaatta ttaaaaatat aatccctatg attgaaaata caattgactt
     6361 accacctata aatttacctc catcaaaaaa catattcact ttagatatat ttaatggaaa
     6421 atatataata taaatatagt catttttatt atttttaatt gtattaaagt atacagttcc
     6481 attacttgaa ttattttggt tagctaatgc taataattca gaattagaat aataatcttt
     6541 atgctctttt ggttctaaaa acccataaac tctatttcca ctagaatcta aaatttgcaa
     6601 ccacaattga ttttctcgaa gtttttctaa tccagactgt tttacttgtg gcttattatc
     6661 tataaatacg atttgttcat taaagttttc tgtaaatttt ttcggccagt cactacgaat
     6721 aaattcccca tttggtttct gaatagtaat aagtgataag aaaataccta ttactgtcag
     6781 gattaagcaa ataaaaatca tgaaaaaaat aatgtatgaa tgaaatactg ttttataact
     6841 aggtttatgc atttaatcaa ctcttttctt aaacttttat tttgattatt gcttatataa
     6901 aatagacaat aattattgat atgtaaaaat ttatttaaaa atacaactat ctacataaat
     6961 tatatttata taattatatg ttatcaagct atctgttgta tttaataaat ccttttgata
     7021 acatataaaa gtaagataaa tttttccatt aaatacctta taattataca caaaatctct
     7081 atatacgtta aacagtatag agaaaatttt catagaacca tctttatagg ggatacttta
     7141 taaaagaata aaaaaattat aatatataaa aacttcatag gagagtaaca acatcagtaa
     7201 aaatatgaaa acactatata aaaattcaaa aatattaaga ataatgaaat acttgaaatt
     7261 gcttatatca agaaatttta tataatataa actggtcaaa tatgttataa tattaaattg
     7321 tgacaagttc atggaggtgt ttatatgaaa aaacaaaagt cgccaatttt acttgaaatg
     7381 cttggactat tttttggttg tatatcaatg agtattggta taaatatgtt tttaaaacca
     7441 catacaattg ctcctggagg acttagtggt ctatcattag tactaaacaa ggttacagga
     7501 cttccagtat cagctatcat gttaattata ggtgtcccat tagtaatact tgcttttaga
     7561 attatgggta caaaaaattc attaaaaact ttatttggaa cagttgtatt ttcagctata
     7621 gttcaattaa cagacccatt atcaaaacta agatttacta atgacttatt attgtcttct
     7681 attgcaggag gaatcctagt tggtataggt ttaggaataa tgtttaaatc agatgcttct
     7741 actggaggaa cagacttaat tgcactcata cttagtaaga aattcccagg aataaaagct
     7801 acaaaattca tgtcatgcct agatggaatg gttgttatat cttctggtat agtaaatcgt
     7861 agtttagaaa ctgctcttta ctctggtata gcactttgtg tattaataaa aatagcagat
     7921 atgataatgg aaggatttga ccattcaaaa gcatttttta ttatctctga tgagcctgaa
     7981 agtttaagac aagctataac tgaagaactt gatagaggtc ttactattct tgatggtaaa
     8041 ggtggataca ctagagaaaa taaagaagtt ctattagtcg tagtttctaa aaaacaagaa
     8101 ctttatctaa agagattagt taaaagaact gaccctactg catttgttat tgttacagat
     8161 gtacatgagg ttcttggaga aggatttaaa aatttagaga actaataaaa attaatattt
     8221 taagtatata tactatttta attaaaatac gatttattca aaaagagtgt ctcataaact
     8281 ttttagttca tgagacactc ttttttgtat aaaatcaaat gcattttcag tattttaaca
     8341 ataaaaacag gattatctat attttgaggc aaccacttta ttgaaatttt atttagaaaa
     8401 caatcattac taaataacca gcatagatat taaatgatta tatctattgt tttttcaatt
     8461 catattgata acaaggaaca tttttcacag tatttccagt atgaattttt ttgatatact
     8521 ttcctgtaca tttaaatcct aataaatcta atgattttgt agaattttgg ttttcttcat
     8581 aggttattgc aattatttta tttaagttta gttctctaaa tccatactgt attactcttt
     8641 ttgttatctc agtagcaaaa tcatgtcccc aatagcttgg atttatacat atacctattt
     8701 ctgcttctaa tgctttagga tttatattat taaaccccat attcccaata actttattgt
     8761 ctcttttata tactatagca aagtggccaa ttttcccttt tttatatgga tttagaaaaa
     8821 atgattttat aaactttctt gtatcttcta aagatttatg ctcactaaat ggtaaatgtt
     8881 ttactactat tttattttta taacagtcaa aaaaatcttc aacatcatct aatgatgcag
     8941 gtcttagtat acaatttcta gtttctaagg ttttcatttg aggatattca gaatcagaca
     9001 tttctaatcc ccctttatac attaatctaa atatactgtt catatttaaa atacgatatt
     9061 aattatataa atgttctcaa attaacctta tttttatttt taataaaaac taattactat
     9121 atgaatcttt caaatttacg aatttatctc tatttttata ttaaattact tgtgaaatat
     9181 gtattctaaa ttatatatta ttagatatca tgcttaaaaa ttctttggtt gctaaggata
     9241 aagatatatc ttttaaatgg cagtaaccta tatttctctt aggtattggc tcttttatat
     9301 ctaatttaaa caatttctca ttttccaaat aatctatgct aaattcttct ataacacaag
     9361 acactccaag atttatatac gcaaattcta aaagtaattc atgagaaccc aattctatat
     9421 ccgggtttag ttttatacct tttgataaaa aatattcatt tacataaagt cttgaatttg
     9481 ctttattttc tagcattatt aaaggcaatg tgtttaattc ttccaatgat attttcctac
     9541 ctttgtattc tatgtaatca tttgcacata caaatatatc atgtatttca atacactcaa
     9601 caatatttag tgtatcatct tctattggca tgtttataat tgctatatct atattcccat
     9661 ctttgagtaa agatataagt tctctactcg ttctatttat tgtagataca tgtatatgtg
     9721 gatacttctt atgaaaaatt tctaaatatt ttaacaagaa aaaacgtgca gctgtatctc
     9781 ctactcctat tttcagagaa ccgtattcta attttttaaa tttatttatt ctatcttctc
     9841 ctgatgatat taactttaat gcagtagtga catgttcact tagaattttc ccctctggag
     9901 ttaattttac tcccttattg tttctataaa ataataaagt atctaattgt tcttctaatt
     9961 gctttattga ctggcttaca gctggctgtg acataaacaa ttccttagca gcaagagaaa
    10021 aactcttatt atttacaact gcattaaaaa ccttataaag ttcaagtttt atattcatat
    10081 ataattactc cttatgtcaa atattagtat tatttatttt acttataatt atatttgaat
    10141 tataatatac atggtactaa tatgacaata ttaattcttt aggaggattt tagataatgg
    10201 atagattagt tggaactgtt tcaagagggg ttagagcacc tattataaga caaggagatg
    10261 acttagttaa aatagttgtt gattctgttt taaatgcgtc aaaaagtgaa aactttgaag
    10321 ttagggacaa agatgtaatt gccgttacag aagctgttgt agctagagca cagggaaatt
    10381 atgctcacgt tgacaatatt gcaaaagatg taaaagataa atttggagat gatactgttg
    10441 gggttatatt cccaatttta agtagaaatc gttttgctat atgtttaaaa ggaattgcaa
    10501 aaggatgtag aaaagtcgta ttaatgttaa gctacccttc tgatgaagtt ggaaatcact
    10561 taataagtat tgatgaactt gatgataagg gaataaatcc ttggtcagat gttttaacag
    10621 aagaaaaata cagagaacta tttggatata acaagcatac atttactggt gtagattatg
    10681 ttgattatta taagaattta atcaaggatt gtggtgcaga ggtagaaata gtatttgcaa
    10741 acaatccaaa aactattctt aactatacaa caagtatttt aacttgtgat atacatacaa
    10801 gacaaagaac aaagagaatt ttaagacaaa atggagctaa aaaagtatat tcacttgatg
    10861 atataatgac agcaagtgta gatggtagtg gttacaatga ccagtatgga cttttaggtt
    10921 caaacaaagc tacagaagaa acagtaaaat tattccctat aaattgtgat gaagttgtaa
    10981 acaaaatcca aggtaatata aaagaaataa cagggaaaga tgtagaagta atggtttatg
    11041 gagatggagc ttttaaagac cctgtaggta aaatatggga attagctgac ccagtagtat
    11101 ctcctgctta tacaaaaggg ctagagggaa ctccaaacga agtaaaatta aaatacttag
    11161 cagataatga ttttgctgac ttatctggtg atgagttaaa agaagcaatt tcaaaataca
    11221 tagttgaaaa agataataaa tctgatgatt taacaggaaa catggtttct caaggtacta
    11281 ctccaagaag attaacagac cttataggtt ctttagcaga tttaacatct ggaagtggag
    11341 ataagggtac tcctattatt tacatacaag gatatttcga taactataca aaatagtatg
    11401 ttttaataag atttaatttt tttggattat atatattaac atgaaaattt attaaaacct
    11461 cttaatagat atgacttttc aagagttata tctattaaga ggtttattta atgttcacag
    11521 ataagatata tttaaataat ttaaacaaga ttgtcagaaa gttatataat cttaaaaatt
    11581 tatataactc taattcttat ttatttctga aataatatca ctcttcaaaa tttgtcttac
    11641 tggaataatt acagcaacta tactaatagt gatatttaaa ataatcatac ctatgtatag
    11701 aggtgtattt attttaagaa ttggatttat atataaatat acacgtttta ccataaaata
    11761 aatcataaat tgtccaataa cacttccaat taccattata atacttgcat agaatccata
    11821 taaaaaacct tctcttatca tcataagtaa aaacttatta tccgtaatac ccatagctct
    11881 taaaattcca aactcatgtc ttcttgaaaa aattaagtag cttactgtat tgattatatg
    11941 gaacaaactt attgcaagaa gtacaaatac aataccatat ataaataaga gtttttgatt
    12001 taagtaggta ttattttttt caatagcaat ggtataatct gttacgatac atctttttac
    12061 atcacttaca acacttttta tgttctcaga caattcctca ctgttactat cttctgtctt
    12121 ttttatactt actgaattat aattttcgat atcaaagtta tttttcattt gcccattcgt
    12181 cataactata tccataccat aatcaccaat gaaatatatg ttatttgcca tcacacgttt
    12241 tacagtagca gcaactacaa attcttttgt tgtataatca ttcttatttt cttctttaaa
    12301 tttaacaatt tcatctgttg gtttcattgt ctttggcact ttaactttta ttgtatctcc
    12361 tggatttata tcaactgcat catacatccc agttccatcc ataggtagtc taactataac
    12421 cttattattt ttaaccatat catgggtatt aatctcccca tctataatat aagaatttaa
    12481 tccttctaac ataccattgt tataaccata aatatttgtt tttaaaagat agccaccttc
    12541 attttgcttt gtacaaatac catcaaaaaa agtctttatc ctgtaatctt tttcaagagg
    12601 tttaaagaaa tttttccaaa atagttgttc ttctttaatt tgcatagctc caaataaata
    12661 tcttactgga tagacttttg atattccctc aacattgttt aatcttgaaa ttttatcttt
    12721 tggtatacct acatcaaaat ctgttgtttg catagttatt tggtagtcag aatttaaacc
    12781 atcatcagct ttcattgtaa gttcattatt atttttagta agctgtatag agtaactaga
    12841 acatagaaat ataattccac caagtgataa tgaaaacaaa attccaataa acattccctt
    12901 tttttgagtc atgtatttat gagataatac ttttgtcatg ttagagtgtt ttacactttc
    12961 taatattctc tttttcttat tagtaatctt aaagtttttc atagattcta tactagagta
    13021 tttattcaac tgatgtacaa cacgtacagc aattaaaatt aacaacaata agataaataa
    13081 aaagcctaaa taaatagatt tttcacttat aaaaaatgct cctggaacaa tatcactact
    13141 caaaaatata tgtggaaatt gttcatatat tgtagacgct actccaatac ctaagaagca
    13201 acctatagga aatccaacaa taaaaagtaa aaataactct aaaaatagta gaaataaaag
    13261 ttgtttatta ttagcgccta atacttctaa aaccccatat tgtgatattc tctgaagtat
    13321 tgaaacatgg aaaatactat atactgctgc tgcaccaaac actccaacaa gcaatataat
    13381 tgcatttgta tttagttcta aattttttaa gaactcaaat atattatatt tttctatatt
    13441 ttttggtggt tttactccaa attcaactga aagagaccag tttatataag ttttttcttt
    13501 tgatatgttg aattttttca taaatttata attttgcttt ttaatatttt tattttcatc
    13561 atattttaca taaactatat aagaatcctt ttctttaggc tgaaaataat cgtttacaaa
    13621 tccctccaga gcagtttctg ggtttgaaag acttgataaa ataccacata acttatagat
    13681 tttaccatct aaattgattt ctgttccaat ttctttgttt acatttaaat tgtttagaga
    13741 atatgtgtca agtactatct ctccatcttt actaggaaga gttcctttta ataattttct
    13801 acctgtcatg tctaaatatg aagaatcagc atttaaaaat tctataataa aaggttcatc
    13861 tatctgattt ttaggttttg taacgccaag tctatctaca gtgtattcct ttgatttttt
    13921 attttcttta attttattaa gttgttcctt atctacttta tagaaataat gataatctcc
    13981 actatcttcc cttatctttt caattctact tttgtctgca ctatgaacta aagaaccaat
    14041 tcccgtcaat aatgctactg atagtactat gcttaaaact atagatatag attgtttttt
    14101 ataatgcttt atatattgaa ttgaaaattt tactagagac atcatagtaa ttcaccacca
    14161 gtattaacca caactccatc ttcaatatgg ataattgagt cgcatacttg tgctatattt
    14221 tcattgtgtg ttaccataag tatcgtttga tggaattttg cactactttc ttttaataaa
    14281 cataccactt ccattgtagt tttactatcg agatttcctg ttggttcatc tgctaatata
    14341 agcgcaggtt tatttgccaa agctctagca attgctaccc tctgttgttg accaccagat
    14401 agttcgcttg gaaattttaa acgcttatcc caaattccca atgtcttcat cagcatttca
    14461 atatattcat ggtctatatg gtttccttta tctaatgtaa caggaagagc tatattatca
    14521 taagtgttta atacgggcat taaactgtag ttttgaaata taaatcctat atttcttctt
    14581 ctaaacactg tcaaatcttt ttttcctatt ttagatatgt tctttccttt aattattaca
    14641 tcacctgagg ttggattatc taatccacct ataatattta acaatgtgct ttttccagaa
    14701 ccagaagttc caactatagc agtaaatgta tctcgttcaa tttctatact tactccattt
    14761 aaggctttta ctttagtctc accttttcca tagtgtttta ctaaattatt cgtcactaat
    14821 atactcattt aatttctcct ttcaatacag atatatgttc tataaaatat tgtaagtgac
    14881 gataattaca ctcatcctac aaaattagtt taaactctta caattctgta agaagatact
    14941 aaaacaacat ccacttccta gtttagattc tactataatg tttccatttt ctttttctaa
    15001 aattaatctt gtaagatata gaccaatccc tgtgccattt tggttttcaa catttttact
    15061 tctgtaaaat cttttaaaaa tatcatttag ttctctacta tcaataccta ttccctcatc
    15121 tttaatagta atcttcgtat atagttccat ttttattaca gaaatagtaa tcgtgctatc
    15181 tgatggtgag tattttattg cattttctaa aacatttaca attgcttcta tggtccactt
    15241 tttattatga actaatttta tgtctgaaaa tggttcgaga tttatcctta tatttttagc
    15301 ttctgcttta ttaaagatag tactgatact ttgaataaga gtatctttaa ttagtagttc
    15361 ttctacttca aattctataa ctccatcctc taatttagtc attttaaata aggattgtaa
    15421 cagccagtca atcttaaaag tttcattttt catcttttgt aaaaactcct tcttctgtaa
    15481 tgtggaaata tttatattct ccagaagttc acaataaatg gttatatttg aaagtggagt
    15541 ttttaattga tgtgacatat ttgatattaa acctttaatc gcttcttttt ctgactttga
    15601 ctgttctacc tctatttcta tcatatcctt aatttttttt acttggtgag aaatttttga
    15661 cgctcttgta tcctttgtat ctggataagt aacttcttta ccttccaata tttgatttaa
    15721 catcaaattt aattcatcat atctttttcg atttattcta gtagatacta taaatataac
    15781 aactgtacat attataaagg ctaatataaa catattattc tacctcattc cataaataac
    15841 ccattccata agctgttttt atatattttg gattagatgg gtcatcctct acttttactc
    15901 taagtcttct tatatttaca gatacaatat tatcatcaac ataattttct tcgctgtccc
    15961 aaatatggtg taaaatttgt tcctttaata atatttgacc tttattttca attagataac
    16021 ttagaagctt atattctaca gagctaagtt ccaaacattc tttattttta tatactttta
    16081 gtaacttttg gtccaatttt attccattgg aatatattac tttattattc gatttttttc
    16141 ttattgctac tttgactctt gcctttaata cagataaaga aaatggtttt gtaatataat
    16201 catcaagccc tatttctaat ccttttactt catcaatttc tgagtctctt gcagtaagca
    16261 ttataattgg tatatctgac ttttccctta ttatttgaca tacatcaaat ccatctccat
    16321 ctggaagatt gcagtctaag attataaaat ctatattttt actattaaat atatttaatc
    16381 cttcttgttt tgtataagcc ttaaatacat taaatccatc attctcaaat gcataaaaaa
    16441 gaccttcatt taagtttata tcatcttcaa taattaataa gttcaatttt actctccttt
    16501 agatttttta gataaataat tattttcttg cattatcata ctaaaaatat tttaatttta
    16561 tttatttcac taaaaagatt gtatttaaat ttgttttcaa aataaaaaca ttataatcaa
    16621 gcatatagtt atatatttcc caatttaatt acgcttaaat tgaaaatata actttattct
    16681 tatataatta aattatacaa caataaagtt atatttttta aatatatttt tactaggggg
    16741 aatagaattg aaaagggttg atgagagaaa tactatgttt gcaagagcaa attacaaaaa
    16801 agatagtact gcttataatg actattataa gaaaaatcct gacaaaaaag aaattgatga
    16861 tagtataaga aatagaccaa atttatgtag tgaaggaaca atgacttaca atgagttaaa
    16921 ctctccaatg gcaagtagtg cattcgattt tttatctgat atcaaatctt tatgcgaagg
    16981 aaaagtttct gatactaaag tagatgtaga tgcaaagtca atgacaaaaa aaattaaggg
    17041 tcttgcaaag cagtatggag cttctgtagt tggtataact aaattaaaag actatcatat
    17101 ttatacaaat aggggtagac atgaagaaaa ttacggtgaa gaaattaatc taactcataa
    17161 gtatgcaatt gtatttggat gtgagatgga taaagaaatg ataaatagag ctccaatgat
    17221 atgtgaagtt atagaaacat caaagtgcta tgtggatgca tctatcgtcg gcatgatttt
    17281 aagttactat ataagaaatt taggatatga tgctagaaat catatggatg ctaattattt
    17341 agtaatgcct gtttttatag ctcgtgatgc tggtttagga gatataggaa gaaatgctat
    17401 acttacaaat aaagattatg gctctagact tagattaggt gttgttacta cagatattcc
    17461 tcttttagaa gatgaatatg ttgattttgg actagaagat ttttgtaagg tctgtaaaaa
    17521 atgctctttt aactgccctt ctcattcgct ttctaatgat attaaaattg gtgatgatgg
    17581 aaaatataat tgggtaattg aacatgagac atgctatatt aaatggagat atttaggtac
    17641 agattgtggt atgtgtatat ctgcttgccc atttagccaa aatctcgaaa ctataaagaa
    17701 tactacttca tttaagggta ataatgagct tattcaaaaa gctttagatg agtatacttc
    17761 aaaatttggt aaaagaatat ttatacctgg aaatccatct tggttgaaat aattttattt
    17821 aataaagaat ctgtactaga atttatcata ggacaggttc tttattaaat atataaattt
    17881 ttaaatactt tttctcgttt ataacaattc agcaatgttt ttagtctata attgacatta
    17941 taaaatatta aactaaaagg agtaactgta tggaaaaaat attagtagta gaagatgatt
    18001 ctatattaaa taaaactcta tcatataacc taattgaaga tggatatata attacttcaa
    18061 aatttacagc taaatctgca ctaaagtcta tttttgaatg tgaatttgat ttaataattt
    18121 tggatattaa tttaccagat aaaagtgggt ttgaattatg taatgaaata aaggaaaatt
    18181 acaatatacc aataattttt ttaactgcta atgatatgga atgtgatatg attaaaggct
    18241 atgaacttgg agctttggat tatataacaa aaccatttaa tatcaatata tttaaacaaa
    18301 aaattaaagc ttttttaaat catcttacaa taaaaacaaa acaagattac tataaggatg
    18361 gatatcttga aattaacttt tctgagttat ctgccaatat aaatggaaat caaattatat
    18421 ttacaccatt agaatatcgt actttaaaac tgcttactga aaatcctaaa agtattttaa
    18481 caaggaaagt acttttagaa aaactctggg atatagatgc taactttgta gatgaacata
    18541 ctttaacatc tgttataagt aggattagaa gcaaaattga aaaagacaat cttaagtata
    18601 tcaaaacggt atatggtatg ggatatatgt ggttaggtga aagaaatgaa ttttaaaaaa
    18661 ttttctttta gttctattta tttaataatt gctgttggta taatttttac agctatttta
    18721 tttagtatct caatttatct aataactggt gatttaaaac taattgctct attattaata
    18781 tatacaatgg tactttgtgg atttatagca ttaataatat ttttacttca taaaaaaata
    18841 gttatatttt gttctaaaat atgtcacact ttagatagta tgatgaatag tgaagataat
    18901 attgaaattg aattagaaga agaaactatt ttatcacgta tcaatcacag attaattaga
    18961 atgtatgaag ttattcaaga aaatcgcaat agtattgcta tagagaaagc tgatttacaa
    19021 gaactagttt ctgatatatc tcatcaaatt aaaactccta ttgcaaattt aaaaatgatt
    19081 aatactactc tactaaatca aacatttaaa acagaaattc aaaaggattt tttaatggat
    19141 atggaaaacc aattagataa attagatttt ttaatgcaat ctatggtaaa aacctccaga
    19201 ctagagacag gtataatcac actatctaaa aagaaaaatt caatttatga aacaattgct
    19261 acagcactta gtggaatttt gtttgatgct gaaaaaaaga atattgaagt tacagttgat
    19321 tgtgacccaa atttatatat aattcatgac aagaaatgga cttctgaagc tatttttaat
    19381 atattagata atgctgtaaa atacacaagt tctaatggta agatacgtgt agctacagaa
    19441 tgttgggtta tgtatacaaa aatagatatt attgataatg gaaaaggaat atcagaaagt
    19501 cgccaagcag aaatctttaa aagattttat cgtgaagaag atgtccatga catagaaggt
    19561 attggaatag gtctctatct ttcaagaaaa attatatctc ttcaaggtgg ctatattaaa
    19621 gttacatcag atattggaaa agggtcgact ttttctattt tcttacctaa taaataaatt
    19681 tttaaaaatt tcatttgtaa tgattctgca acattttggt tttatactgt atttacaaga
    19741 tgttaaggag gtattattat gagtatttta caagtaatta atttaaagaa atattatgga
    19801 caaagttcaa acattacaaa agctcttgat ggtgtaactc tatctattga aaaaggcgaa
    19861 tttatttcta ttgtaggtac atctggtagt ggcaaatcca cattattaaa tatgatggga
    19921 ggattagata atcctacatc tggaaaggtt attataaagg gtaaggaatt atctactatg
    19981 tctgatgaac agcttacaat ctttagacgc agaaatatag gttttatatt tcaaaattat
    20041 aatcttgttc ctttacttaa tgtatatgaa aatattatct taccaatagg attggatgga
    20101 gagaccatag ataaggattt tataaatgaa attataaata tgctttctct tgaagaaaaa
    20161 ttatatgata taccaagtaa tctttctggt ggtcaacagc aacgtgttgc tatagctaga
    20221 gcacttgtaa caaaaccagc tattatacta gctgatgaac caacaggtaa ccttgatagt
    20281 agaactagtt cagatgtact gagtttactt aaagtgacaa gtaaaaaatt caaccaaaca
    20341 attgtaatga ttacacacaa taatgaaatt gcacaactaa ctgatagaat tattcgtatt
    20401 gaagatggaa aaattgttaa ctaggaggtg tagtatatgt ttagaaataa taatcgcaca
    20461 tttataagaa aaatagcttt aaatgattta aaaattaata aacttaaaac atatctttca
    20521 ggtatcatta taatgatttc tacatgttta ttattaacag tgaccttagt ttcatataat
    20581 gcctctgtag atttagttaa tgcatctcca tatcatgcta tatataaatc tgtagatgaa
    20641 aaagcaaaaa atatactata taaaaataaa aactttagtg gcgtaggaac ttacaaatta
    20701 attggaagta ataaaaagac agattgtatt atgtcgattg tttatgcaga tgatacagca
    20761 attaaactta tgaattttca accattgaaa ggcaaactac ctacaaataa aaatgaaatt
    20821 gctatttcag aaaaatattt acaggaattt ggtttagata aagatattgg agatagcatt
    20881 aaattaaatt attatgatga tattacgaat aaagaagttc aatgtgattt tattattgtt
    20941 ggatttctag aaaattatta tcaagataat gccaagcaat actatacagt cgtttcaaat
    21001 gattatttta agaatatagc ttctacacct ttacaaaata aaagtaatac ttttgacgag
    21061 tcaagacctg atactgtaga tgtattagtt aaactatcag aagaaaatac agagaaagat
    21121 tcagcttcaa ttaagacaca gttaaataaa attggtttat ctttaggtat taagaaatat
    21181 aatatatact taaatgataa ctatattgaa tcaaatttaa ttgatggtga gcagattatt
    21241 acagttttag tagttggaat agttgttctt ttttctagcg tttttgttat atatagtatt
    21301 ttttatattt cagttgttaa ttcagttcag atgtatgcta agttgaaatc gttaggtatg
    21361 acttcttttc agttaaaaaa aattatttct ctacaaggaa atattttgtc aattattttt
    21421 attccattag gggttatagc ttcttgtata attgcttaca taattcaacc attagcatgg
    21481 caaatgatag ctgatttatt tataatttta attttatcac tggtaatgtt tttaactgtt
    21541 agaatttctt tatttaaacc agctagaatt atttctaaaa tatctgctat tgaagccatg
    21601 caatatacag aaactaaatt tagaaaaaaa gcaaaaaatt ttagttatat aaatataaaa
    21661 aatctagcat taaagaatat cgagtcaaat agaaagaaaa atttgattgc attaatatcg
    21721 ctaagcatta gtggagtttt atttatttca atcgctaatc ttgctaattc aatagatttc
    21781 aaaaaacaac tatctcaaca atttgtctat aacgaagatt atataattag cattaagagt
    21841 gataacttat atgagcatat tacagaaatc caacaaaata atccactaac agattctctt
    21901 aagaatgaaa ttaaatctat tcatggagta aaaaaattaa ttgaatccaa atcaattaaa
    21961 agtaatatta tagaacctta catcaaagat agagacgaaa aacaatttat tactctaatt
    22021 aaaggtatta cgcctgaact ttcaaaatca cttgaagaat atattgtcag tggaaaaata
    22081 gactatacac atttagattc agatagttta attataaata aatatagaac aaaatattat
    22141 ggattaaatt taaaagttgg agatacagtt acatttaata tctttagtgg aaatgatatt
    22201 attaaaaaga aaatgaaaat tataggaatc attgacaatt ccaatacagg aggtatgttt
    22261 tttgcttcag acaaaacttt agaatctcta acaccatata atacaaattt agatttttct
    22321 attttaatag ataaaaagca ttctaaagaa gttgaagaaa agttgttaag tataattcag
    22381 aaaaattcaa atttaatgct ttattcatat gaagatgatt atagaatgat tactagagca
    22441 tttcaatata taattatagc ttcatacatt tttgttggtt taatttcttg ctttggtata
    22501 ctaaatatga ccaataccct aataaacagc gttttaatta gaaaaaaaga gtttgcatta
    22561 cttcaagccg ttggaatgac aagaaagcaa ctgcgaaata tgctttatag agaaggtcta
    22621 aacataagta tcaaagctat atgtacttca agtacactag gttattttgg ttcaaatcta
    22681 ctttgcactt ttataaaaga tgtaattaga ttagacttta ttaattttaa attttctata
    22741 tttactattt taattttttc attcgtatta attggtatac aagttttagt gactgaatta
    22801 cttgtaagaa atatagaaaa aaaatcactt acagaacgct tacgttctca gtaagaatgt
    22861 atataaaaaa tagccatttt ttatacaagt tttaatatga ttttttaaaa gctataggga
    22921 tagaaaattt tgactttaca taattttcta tccctatact tgtttttatt ttatacagat
    22981 acacttactt atatctccga gcaacatcac cagagacata aacaagcata ttccttattt
    23041 tctaaatatg tcaattgcat gacttgtaac ccctactaaa tcttcacgtt cacaagtagc
    23101 aaggtgatat tttaaatata atgcaaatgc atcatcatcc atagagtcta ctgcttcacg
    23161 catatataaa gccaaaccat ctgatgcgac ataatgcagt ctagttacat taaatgcaga
    23221 catcaaatca tcaatgtttt ctttacgtac aagctcaaac aaatcctttg gttcagactt
    23281 agcagcaaat gtctgtggat caatcaaacc tttttcaata tattcagata cattaatatt
    23341 tcctctatgg aacccctcgt caatgagaca gccatcagat ataacatatg cagcaaaaac
    23401 cacaccacca ggttttgtta cacgaattgc ctcatgtaaa gcttgttgtt tatcttcttt
    23461 gttataaaga tgatatagtg gtcctaacag taacgtaata tcatatttat tatctgggaa
    23521 aacagataaa tccatagcat taccctgagt aatgcttata ttttcatttg attgagtatt
    23581 tttatggaaa acctctatat tatgttcgac taattccact gcgtcaacat catatccctg
    23641 acgtgccagt gtgtgagaat aacgaccagt tgcagcgcca atttcaagca cacaatcacc
    23701 tgattttatg tacttatcaa tgtaatgcat agtagtgaga aattccacca ttccatgttt
    23761 taatgcaagt cgactatctt catcataagt attataaaag tcaattaagt attgttttgt
    23821 ttccataatt tcacctcttc tatattagtt aataaacatc aaatagacaa attccaatct
    23881 ggtttttctt gtcttataaa agctgttaat atatttttca acattttttc agcactatat
    23941 ctatctaatg ttaatttttt tgttgctgtt aagacagcta tgccatgagt ataaagaaat
    24001 aaatctaaaa atattacttt tgcacattcc aactctattc caatgctttc cgaaaaaagt
    24061 cttgcctttt tttcattgtc aatttcttta taaaaatcat ttgcctcttc catcatcaaa
    24121 tctaaatcat ttataaataa caacttaaat aaatgagttt cttcttgagc aaattcaatg
    24181 tatgaaagcg gaagcagtaa ataaggactt acacttttag aattactata attaacaaca
    24241 tactgattat agtattcata tgcaaaagca agaaattcat tttttaattc attcatgttt
    24301 tcgtaacaag taaaaattgg tcgagtggaa cactgtaatt tacttgcaat actcctcgca
    24361 tttacagctt caaatcccac ttctcttgta atatccaaga ctgtattcaa aatcatttct
    24421 tttgttatct ttactttagg tggcatatat gttcacctct ccattaaatt tttataaaac
    24481 acatatgtta tataactata gtaacatatc aagaaattat gtcaagaaaa agctttgcat
    24541 ttttttgcaa ttcctaaaac ttataaataa aacatgagtt gcaattaatc tattaataga
    24601 taacagcaac tcagattttc ctttaaatac tcttcttttt gtctaatatt tcatatacac
    24661 aatcttctat tgaattaata tctttttctt ttcttttttt agaatcaatt aaaatgaaat
    24721 acagtataaa acctacagca agtccccatg ttccgccttt agcagcaatt acacctccca
    24781 taagtccaat caatcccttc tcaacacctg tattacatag ctccattgat agctttgtac
    24841 ataaatatcc ttgaactaaa agtgttactg acaatgctaa tggtataaga ggtgtagcaa
    24901 tctgcgcaat tggataaaaa cagataaaaa ttgctgaaac ccatactaat gtacccatgc
    24961 cactaaaaac agactgcatg gcttcctttc caaccttgta cctttgagca acacttcctg
    25021 taagtgtcgc agctaatgga ccgcacattg gtatatatgg agaaaagatt gccataaaaa
    25081 tatttcttat cccacttata acattagacc tatttgaatt gaaatctata tattcatctt
    25141 ttctattttc actttcagaa agtactaagt tttcacctgt tataaaatca ccaaaggcaa
    25201 ttatgtatat cataaaagcc attggtatcc cttgtataaa taacattaca cttggaaaac
    25261 ctattccaaa aggagatact gtatttatca gatttttaaa atctactatg taaactaaat
    25321 tgtcaaaact aaatctagga atttctattt ctttactaaa tatacctact attaaactca
    25381 ctaaaatagc tgatactaca ccatattctc ctaaatgaaa taaaaattta ttcttaactt
    25441 ttagagtatc aaatctttca gaaaacatta caaaacaagc aaccaaaatt cctactgtta
    25501 tagatatagg ataagaatca aatctccctt taggattaaa ctctgatatt atagtcgata
    25561 taccgacacc cattagtatt ccacctttaa tagaatttgg tatcttacta actaactttc
    25621 cagctacacc agttataccc attaaaataa atattattcc taaatctatt tgtaaagctg
    25681 ttaatgcttg tattctttca atgcccatgc tgaactttaa caaatatgca gttgtaagag
    25741 ttatagaagc tgtaatccag ccaggtacaa ctgggtctcc cataaaaaca tgcaaacagt
    25801 ataatattga gttaatgata gccatactcc atgccacttc atagggtaat cccaaaattt
    25861 gtgtactaag gccaattgtg cctaaacttg tcatacttga tattatacct tgaatagctt
    25921 ctggtttctc aaatctgtaa tgtataaatg gaattcttat cttaaacatt ccaaatttta
    25981 tatgaggttg ttcccttcta gcgagtcttt ccataacttc actccacctt tcaataactc
    26041 ttataagttt acaactttat aattgtttat aaattatcaa tgtcattaaa attagtatat
    26101 aacatgcaaa ttatataaac aataaattaa atctataaaa ttgatagatt ttgtgcatat
    26161 atagaaagac cgcttcattt ttagttactt aaatcactta atattagtta tttaaatcac
    26221 ttgataaagg ttttttataa aattcaatag ttctattcca tgattcaaac tgtccttttg
    26281 aatttccttc tacagttcca cctgaagaaa aaatccctct actcatactc atacataaag
    26341 tctcctttag aggcataata tatggaattg gtaacggata acccatatta ttgtatgtta
    26401 ataattctac gttatatgga taattatttt cttcaaagat ttctaatgcc tctaaacaag
    26461 cttcataact attccatatg ttatcttctt ttccagcaat cataagtata tctgctttgg
    26521 aattttctat ttttattcta gcctcttttc tattctctgc tcttttaaga cttttcttat
    26581 aagtactatt aaatccaaat ggaatatctt ttgatatatt ttttttctgt tcttcaaaga
    26641 atatatcatt gtctactttg atatatggaa atggctctcc tttatatgac catgatgaag
    26701 tatcatttcc actcatcaat ccattaagag cttggaaaca ataaatgtga ggttgtgata
    26761 ctacaacctt tttaatttgt tcatatcttg aagcaagtaa aaaggccaat tctccaccct
    26821 ttgatgtccc atgtacaaat atttctttag tactggtaat ttcattttca ctaatccact
    26881 caaatacttt ttcaaaatat tctaatggaa cctcttctaa tttatctggt aacccttcta
    26941 aagcaaagta tgcaactgtt agtacattga atcctctaga tgcaagtgga gctgctaaaa
    27001 ggtctagagc gtctaaattt ccatcagaac cacctagcat taaaattgtt ttattattag
    27061 aattttgttt ataaaataat tttcctataa actcatcaga tatgtatttt gtggtaatat
    27121 cttctgattt aaatattctc tttaattcaa cttcttttct ttcaatagaa gtttcaaata
    27181 tcatattcat aattattggt ttatcaatag atatattttc tgcaaaattt ttaccttcag
    27241 ttttagattt ttccagcgaa taaattaacc ccatacaatt atcagcctta taagtacctt
    27301 ctataggttc aactaaatct aaatctactt ctcctttttc atttgaacaa aacactccat
    27361 aagatgaaaa ttcttctccc ttacaccatg gaaattccat tttcacactt attttaagtt
    27421 tagtatttgg aattaagtct gaaaccataa tcttaagtct ttcatccaca aatgattcta
    27481 cattgtatac atttactttc ataatctatt tctccttata ataattattt atgttttata
    27541 taaaacagct ttatctaata caagataaat aaatttttaa attaagacac catattgact
    27601 atttcatttt atcaacatat ttcatctttg tcaacatatt gtctttttta gtaatttaaa
    27661 attatggtct atatgaaatc cagttgattt ttggctaatt aaagatagga atgctattag
    27721 gtttagaata tatatattca aaataaaaaa ccactcattt aaagaatggt ttttaatata
    27781 aactatttgt tattaataag gatatttttt tatttaaatt tatataatcg aacatctaat
    27841 atttaatgtt taataaaatt atgcatttgc aaaagtatat atggcattaa ctcttgctac
    27901 atataaattc tcatcactac atccaatata tctagcatat ttttcaatct tttcttttgc
    27961 attttcaaca tcattttcat cgctctccat taactcattt atataaatat ccattaatga
    28021 cgctttatat tctcttatat catagcctaa aaattcagtc aatctctcaa tttccttact
    28081 aaaatctcca tcttctttta ccaaaaattc gtatacatct tccctatatg gatttaaagt
    28141 tattatttgt tttactactt tgcattcgtc agccttccca ataaaaccat ctttataatt
    28201 attaaataag gcattagatt tttttataga ttcttcatca atataagaat gtaccgcagt
    28261 tatacgattt tctataaggg catctacaac agcataatga attttaaaac aatcattgta
    28321 taaataattg ctcattttct ttattgtcga ttctatttct aagaagctcg cgtggccatt
    28381 ttttttattt ttatttggta taataaaagt tttattcaaa ttattaaaaa gtctcttaaa
    28441 atctaaatat ttttcacaat aaacactttt aaaggtatcg atatctatag ttataattcc
    28501 aaaacttact atagtctcaa ttcctttctt aaaagactct tctatatatt tttctcctaa
    28561 acttaaacct ctatcagata tttgctttag attttgaaaa ctatttaaac aatctctttc
    28621 aaagttttta gatatttcta aagcatataa tttaaagatt ttccttatct tattataatt
    28681 attttttgta tcatcaaatc tgataatagc tccatttaca tcaaaagtaa tcattgagtt
    28741 ttaacctccc cattagtttc atcaataaaa taaatttaat ataaacttta taatcataat
    28801 attaaactta tttatactat aattattaat ttgatgataa aagctatttt ccttctaaat
    28861 aaaaaatttg tctaaagttt ctaaaaaatt tagacaaatc ttaggttatt actctttaaa
    28921 ttatttttaa attattccaa atacgccaaa taatattggt ataaatatag ctggtaacaa
    28981 attggctact tttatattcg ttaatttaag tacatttaga ccaagtccta taattaataa
    29041 acttccagct gctgtcattt ctgtgactac aggatcactt aaaaatccat ttaaaaatga
    29101 tgctcccaca catataatac cttcatacaa aaatacagat attgcagaaa acattacacc
    29161 tatacctaaa gaagcagtaa atataattga agctattcca tctataacag attttacaaa
    29221 taaagtatca tgacttcctg taagaccact ttctaatgaa ccaactactg ccatggctcc
    29281 tatacagaat aataaactag atgatataaa accctctgct atagaatctt ttttatttcc
    29341 tttagaaaat ttactttgta aaaaagcacc caacttattt acccatttgt caatatctat
    29401 taattctcct atcagagcac ctacagctac ggatattatt gtcactaatg tgttttttcc
    29461 ttctagtgct cctgatatac caatgtacaa tacacataaa gcaattccat tcattatagt
    29521 atcgcttact ctttgaggta atcctccttt tattataaga cctactatac atccacctgc
    29581 aattgctaga ctatttgcta ttactccaaa cattttttct cccctcgatt agctaattga
    29641 aatttatcct attattaaaa cctaaacatc tatactttgt attggatatt ttaaatattc
    29701 caaaaattct tcaaaacctt ttctagatat atttacagtt ttagtattta tgttaggatg
    29761 aaaatttaag taatcttctt taattacatc tttatctatg taaagctcaa cttttctttc
    29821 tgtatcattt attaatgaaa aaggatttac acttccagga agaagtttaa gtacattgta
    29881 tagtctttca ggtgaagcaa acgataatct agaacttcct atcttatctt taagtgagtt
    29941 taaatcaact tgtttttctc ctttaactac aataagataa tacttatttc ctttggcatt
    30001 tcttaaaaat aaatttttac attgacaccc ctttgttatt ccatctaaaa tgactaattg
    30061 ctctgctgta tatacagctt catgctctac tacatcatat tcaacattta atttatccaa
    30121 aatatcatat attttagttt cattcatgct agattcattt tcatcttgtt cttttttatt
    30181 atttaaatca ctcatacttt tctccttaaa cacttcatca taatatcatt gtgaggtatt
    30241 attctactat agctattgct cttactggag ctccatcagc atcattatac ttaaatggtg
    30301 ctgctataaa tagaaatttt tctggaacat tttctaaatt tgtaagattt tctatgatta
    30361 tttttccttt ttcaaataaa atatgatgca cttcaaatac tgatgtgtca tatctatcca
    30421 ctgatagcat atctattcct atgcctttta tattagtatt agctatatag tttgcagctt
    30481 cttttgttaa tgtaggataa cctacatagt actgcttttt atcccaaaat tttgaccaac
    30541 ctgatttaaa tattataaaa tcactatttt ttatttcatc ttcatatttt tttagatatt
    30601 ctaattctat attctcattt cccttttcaa gttccaatac ataagctttt ccaacaaaat
    30661 tttctatatc caacttatct agggtctcac ctttagtata catatgtctt ggtgaatcca
    30721 tatgagttcc attgtgagaa aatacactaa ttaatgtttc ttgataacca ttttcttcaa
    30781 taatagctac tttcttgata tctggtctat taggctctgc atatacaggc atgtcattat
    30841 gtgtcacatg agttaaatca aaaaccttca tctttatata ccccctatgt ttttattttc
    30901 tattatatac ctaaattcat tttatttcta tcagatttta ttccattata taccatacta
    30961 ctatatattt tttataaacc tcaagggatt taccgaaaaa tcttggaaag aattatcagt
    31021 aaatataaca tcttcaccca aaaaacgttt ataccttcct tcttctttct ttaaagtaat
    31081 tctctgtttt tgtgaatgat tattaaaaac cattatctta agaggaggtt tttttctatt
    31141 agtctgcact ctttttaaca tgtattttat gtgcatatca gcttcaggaa atgaatatcc
    31201 acaaaatatt aaaaggtcag tatctcttaa agttttttct gtttcattcc aaacattact
    31261 taaaaatatg tttgacatat tcttaaaata tgttggtggc actataatag gttctgttaa
    31321 ctcaccacac tctaaacatt ttgtctctga actattttca ataagcttca tgacaccacc
    31381 ttcatgtggt gtaagagtta cactattaca aatggggcaa taaagccaat tcaatgaccc
    31441 atgtatctta tataatttga ttaatggttc ttttggtttt ctccaattta actcctcttt
    31501 aaaatttgta aactccacac cataatcaag cataattggc aaatcattct tatctcttaa
    31561 tccagtaact gtattgtcta tatgtatatc ataatttgca ctaataaaag tagtatcaag
    31621 aagcaaatca ttttccaaaa gattttcaac taaaagttta tgatatttat tatctgttct
    31681 aggtgtatta tgaattgctt cagccattag cagtattaaa tattgtctta aaaaacgtat
    31741 actatcactt ctgttattta gattttctag tccaaaattt ctaaatgctt cttttctttg
    31801 ttctgctaag tctaaaagac ctaaaacttc ttcaaaggta ggaaaatttg cattatctat
    31861 attatctttt actatatcaa tattgaacat ctgtttaaag aaaatataca attctctatt
    31921 cattttggta ttataatttg tgggatttag ttttttaaaa tattcgctaa aaagttcatt
    31981 ttgaataggt agattctctg ctgctgaagc tcctgctcct aaaaatattg ctattttcat
    32041 atagttcctc ctaatataaa tattactcct atttttatat ccattaaata tccatatcat
    32101 ttattttatg atacaacaat aaagctgtct tttactagaa aaaatcctat tacaagacag
    32161 ccttatatta tattaaatct ttaataattc gtaaatagaa agagcatata tttgagtagc
    32221 ttttataata tcctctacta ttaagtattc attagcttgg tgttctgttt ctggttttcc
    32281 tggaaaaata gctccaaatg caacacaatt atctaaagct cttgcgtatg ttgctcctcc
    32341 agatgaaagt ggtgttccat caagaccagt ttcttcttca tatacttttc taagtgtctt
    32401 aacaagaaga gtatcttctg gaacatagat tgaatccaag aaatcatatt cttcataatt
    32461 taaattgtat ttatctgtca ttttctttaa ctcttttaca aaatcatcct ttttgtatgt
    32521 tactggaatc cttacatcta ttcctgcaaa ttctttttcg ttatcaatag ttactctacc
    32581 tatatttact gttagtttac ctgatacatc atccttgcaa ttaggaatta tattgtttcc
    32641 attagcatct tcaccaataa cttctgctaa aaacttaatt atattagaat ctatacctat
    32701 attattaaga gctatacaaa gtctagccac tgcatttata ccagtatcac ttgctgctga
    32761 atggacactt tttccaatta tacagatttt attaccttca acagtatact caaaatttaa
    32821 tttatcaagt tcttttttta atttatcaga gtattttcca atatagattg ctttacctgg
    32881 aactgcattt aaagcctttc caactgacaa ctctatatca cttttgctat cacaagtcaa
    32941 atgaacttgt aaaagacctt tctctgcatt tgttattggg aatctagaat ctggagtaaa
    33001 tccatagttt ggtatttctt cattattttc tttatattta tttatacatc tccaaagatt
    33061 ttcttcatca gccccaaaaa tgaatcttat cctcttatta aagtctacat ttaaatccat
    33121 aagagctttc actgcataaa ttgctgatat tgtaggtcct ttatcatctt gtgttcctct
    33181 tccatacaat ttaccatctt ctaaaacagc ttcaaatgga gggtaattcc agctttctaa
    33241 atcaccttct ggaaccacat caacgtgacc aagtatacct atcatttttt caccttgtcc
    33301 tatttctgca tatccataat atccatcttt gtatactgtc ttaaatccta aagatttaca
    33361 taagtctaat atacctctta aagctttatc tacattttca ccaaatgggc aattttcagt
    33421 tgcttcagat ataacactag gtatttttac actttcttgt attgaagaaa tcatttcatc
    33481 ttgtagagaa tttacttttt ctttaatttg ctctttcata ttatcaccct tcaattttca
    33541 tcataatata ctaataaata ttttgacctt ttaaaaaaaa aatatgctta ttttttcagt
    33601 ttttttataa attcaatcgc ttttaaagtc cccatttttg aatggtcaaa tgtaagtcca
    33661 ccttgaaaat aaacattata aggaggtctt attggagcat ctgcacttaa ttctatagaa
    33721 gaaccttgta taaatgctcc tgctgccatt atgacttcac tttcgtatcc aggcatgtcc
    33781 caaggaacag gttttacata agaatcgact ggtgcagctt cttgtatacc ttcacaaaaa
    33841 cttattactt catcagcatt attaagtcta atacattgaa taatatcact tcttaagtca
    33901 tcatattttg gtaatacatc atatcctaat ttttcaaaag ctcttgagca aaagatagct
    33961 cccattacag cctgagatac tatataaggc gccaagaaaa aaccctgaag tacatttcta
    34021 gttgttccaa aagtaagacc acattctttt cctattccag gagaagtcat tctataagat
    34081 ataagctcaa tcaaatcttt tctaccagct atatatccac ctgtcaatgc aagcccacca
    34141 ccaggatttt ttattaaaga gccagccata acatctgctc caacatcagt aggctctttg
    34201 gtatctaaaa actcaccata acaattatca accattacta tagcttctgg tttaacagac
    34261 tttattactt ctatagcttc ttttatatca ctaattgaaa gtgattttct ccaagaatat
    34321 ccttttgacc tttgtatcat aacgagttta gttctatcat ttattttgtt tttaattcct
    34381 tctaaatcta agtttccatc ctctaaaaaa tctacatcat catatgtaac accatactct
    34441 ttcaatgaac ctttttcttc tcttatgcct ataactccct ctaaagtatc atatggtcta
    34501 ccagtaacag ataaaatttc atctcctggt ctaactatac cttgtataca taaagtaagt
    34561 gcatgtgtac catttacaat tattggtctt acaagagcat cttctgtatt aaatacttta
    34621 gaataaattt cctctatttt ttcacgacca atatcattat atccatatcc tgtagtccag
    34681 ttaaagtgca tatcacttag tttagattct tgcatagctt ttaaaacttt atattgatta
    34741 tattctctta tttcttttat ttcttcaaac ttatctttta tttcttccat tatttcttgc
    34801 gatagtttaa aagtatcatc atctattcca tagtagtctt ttaataattc ttttgtctca
    34861 ttaagcattt tatcacctgt ctctttatta ttttatttaa acatgtaaag gagactattt
    34921 tactaaaaca aataaattat agtttataag ttagtataag tctcctctca atcatcttaa
    34981 attaaattaa ttatctatct gttgttatta ttattgttgt tttggttttg atttgttaga
    35041 ttaatatact ttccaggttg tatagttgat acagcatgtt tataaatcat gttttgttgt
    35101 ctattatccc cttctattaa tattatataa ctatcaaacc cctttacaag ccctttaact
    35161 tgcactccat taactaaata tatagtaaca ggtatccttt ctttccttgc attatttaaa
    35221 aacaaatctt gtaaatttaa aactgtattt ttcattagat ttgtaccctc ccaagattaa
    35281 attgaacttc taaaatattc ctaccttata ttctatataa gttatgacaa attttcaata
    35341 ttaagttgta tacttaaaaa tttatatatt attttataga atctttaata tataagatta
    35401 tttcattttt taattcgtct atattttcat attggtctaa atcaaaccat tttgctgttt
    35461 tatatctttt aaaccatgtt atctgacgtt ttgcatacct tctagaatct cttttaatta
    35521 tttcaatagc ttcttcgtat gtatattctc catccagata ctttaatatc tctttataac
    35581 ctataccttg cattgatatc atatcttttt taaatcccat acttaaaagt ttttttgcct
    35641 cttcaaccaa tccattttta atcataatat caactctcat atttattctt tgatacaaat
    35701 gttctctatc tctatttaga actattatta ttggttgata ttcttcatta aattttaaat
    35761 cacttgaaaa atcattcatt ttcttaccac ttagacaaac ttcaagagct cttatgaccc
    35821 ttttagtatt gtttttatgg attctattag cagattcttc atcaagttct tttaacttat
    35881 tatgcatgta atctattccc ttttcagcaa gctgtttttg aagttcttct cttaattcat
    35941 tattggcatc agattgtgca aaatccatat tatatattaa agagtttaaa taaagtcctg
    36001 tgcctccagt tactaaaaca catttttcct tttcatttat ttcatgtata tatttttttg
    36061 ctctttgttg aaactctgaa actgaaaatg gatagtcagg cttaacttca tctataaggt
    36121 aatgcttcac tccttgcatc tcttcctctg taacttttgc acttccaata tccatatatt
    36181 catatatttg catagaatca gctgaaatta tctctgcatt catatctttt gctaatttta
    36241 ttgacaaatc tgtttttcca acagcagttg gacctgtaag tattataagt ggtatttttt
    36301 tcataacatt cctttccata tattttaaat atccaaatat tttacataat tcttttaaac
    36361 attttttcta tttctgtctt agatatttcg accattatag gtcttccatg aggacatgta
    36421 aatggattct cacacttttc tagctgttcc aataaacttt ttatttcaat atcgtatatt
    36481 ttatcatttg cttttatagc agacctacat gccatagatg caaatctctc tccttttaaa
    36541 tcataattac ttgtaatttc ttctatatta tcaattattt gaagtataaa tttctcagtt
    36601 tcaggtactc caaatatagt aggaacacat cttaccatta tatgattatt gccaaaaatt
    36661 tctagctcaa aaccaaattt cataaataac tccaagttat tttcaatttg aagcatatct
    36721 atatttgata cttcaataac cactgggtct aaaagtattt gcatatttat atcttgtcta
    36781 tagaacttct ccatatatct ttcatatagt attctttcat gtgcagcatg ttggtccaac
    36841 aaatacatag aatcgtcttt gctcaaaatt atataagtat taaatacaac tccaattaca
    36901 aaatatccgt ataaagaaaa cttgcgtttt gaactacaca agtattcttc ttcactgtcc
    36961 ttaatactat ctcctaagta ataatttcct tcatttttaa ttccatcaac ttgaaactct
    37021 tcttgtatat tatcatttgc actatcttca cttagataat taatgttttt tacatcatct
    37081 tctacacttg catttaggac ttcacttact gattgaaatt catttattgg tttttcactt
    37141 gataaagtaa caacttcaat gacttcatcc ttacctttag taatattact atttttagga
    37201 gtagattcta ataaatcatt atttcttaat ttataatctg tacttttttc tctactgtta
    37261 atagcgattc taggttgtgt ttttttatca ctataagtag catattttcc aataagattt
    37321 gagtgtatta atttaacctt taaaaaatct ctaagttcta tatacacttc ttgttctttt
    37381 tcaaatttaa tttcaagttt attggggtgt atatttacat ctatacatga tgggtctact
    37441 tctatattta agaagcacac tgcatgttta cctattggaa ttatagactt ataactttct
    37501 gttattgcat ctatgattat tttacttttt acaaatcttt tatttatata gatatgttgt
    37561 aagtttttat ttgaacggta tatattgtta ttacctatat atccattcat tttaaagtga
    37621 ttgcacttaa actctacatc tattatattt tccgttattt cttttccata tatacttcta
    37681 atagtgttta caagttttcc atcccctgga gtatttagca tctgtttatt gttatttgta
    37741 tatttaaatt gaatgtttgg attacctatt gcaagtttat ttatcaaatc acttatgttt
    37801 atagtttctg catgagtaga ttttaaaaat ttctgtcttg ctggtgtatt aaagaaaata
    37861 tcttttataa tgatggtagt tccattagta gaacctattg gttctttcga tattattttt
    37921 ccaccttcaa catatatttt agttcctatt atttcatctt tagttttagt cgtcatttct
    37981 aattttgata cagctgaaat agatgccaat gcttctcctc taaaaccaag agagtataaa
    38041 tcatacaaat catcaatttt tttaatttta ctagtagcat gtctcaaaaa tgatttttca
    38101 acttcacttg aaggtattcc tattccatta tctgtaatct taattagact ttttcctcca
    38161 tcaattatat ctatggaaat tttatttgca cctgcatcaa tggagttttc aataagttct
    38221 tttactacag aagaaggtct ttctacaact tcacctgctg ctatcttatt tatagtcaaa
    38281 tcatctagga tgttaattat atttttcatt tttacacctc taagatttta tttcttttgc
    38341 ttttctttga agattataaa gagagtttat agcatctaat ggagtcatat ttaaaatatc
    38401 cagatttaaa atttcttctg atagtatatc tctatttaca ctatcaaaag agatttgagt
    38461 taaggctact tcttttacag aatcttcttg attaattttc tctttatcat cattttgctt
    38521 cattaaagca acttcatcat ttaatgcttt aaatttagaa tttaatttat cataatcctt
    38581 ttttatatgt ttgtagtctt ttactataag ttcatgttct atttttagag attcatattt
    38641 attcttaaaa ttactttgat ttaccttaac taattcttcg tccaaattac tattaattat
    38701 attattgttt tctttatctc catttattgc aacactgttg taaacatgat ttttttccaa
    38761 gtctttaagt atatattttg ctctttctat gacttcgtct ggtaatttag ctaatttagc
    38821 aacatatatt ccataactct tgtctgctcc ctgaggaatt atttttctta aaaatattat
    38881 tccttcccca tcttctttga ctgctattga ataattttta acctctttaa actcttcttc
    38941 taaatcagta agttcatgat aatgtgttgc aaataatgtc ttacatctaa tatttttttg
    39001 aatatattcc actattgacc atgctaaact tataccatca taggtactag ttccacgacc
    39061 tatttcatct aatataacta aacttctctc tgttgcattt tttaatataa gggatacttc
    39121 gttcatctct accataaaag tagattgacc ttgagataaa tcgtcactag ctccaactct
    39181 tgtaaatatt ctatctaata ttggaatatc agcagactct gctggtacaa atgagcctat
    39241 atgtgccata agagctatta tagcagtttg cctcatatat gttgatttac ctgacatatt
    39301 aggaccagtt attatgttaa taatgttttc tccacgattt aaataagtat catttggaac
    39361 gaaattttcc tctcctacta tattttcgac aacaggatgt ctaccatttc ttatatcaag
    39421 tttattattt tcatttattg ctggttttac gtagttattt atatgtgcaa ctgttgcaag
    39481 ggacacaaaa acatctatat tagctatagt cttagccact ttttgtattc tatctatgtt
    39541 tttatatatt gtatctctta tctctacaaa tatctcgtat tctaaagatt taatcttttc
    39601 ctctgcatgt agtatctttt cttctatttc ctttaattct ggagttatat atctttctgc
    39661 attactaagt gtttgctttc ttatatatgt ctcatctagc tttgcctgtt taaagttggc
    39721 ttttgttatt tctatataat acccaaaaac tttattaaat cctattttta atgatttaac
    39781 tcctgttttt tctctttccc tgttttctat ttcctttaca agaaaggctc cattcttaga
    39841 aatctctctt agttccttaa gttcatcact aaaatctgat ttaattatgt ttccatcttt
    39901 tatggttatc gtaggttctt ctagaatagc ttcatctatt aaattgtata tatcatctaa
    39961 tttatccatt tctgaaacat actcttttag gatttttgca tttgataaat ttatagtatc
    40021 ttttaaatta ggtaactttt ctatcgaatt ttttaagtga attaactctt ttggtgttac
    40081 tctctcaaat gctatctttc cacatattct ttctatatcg tatatatttt taagtatatc
    40141 atttaggtct tctcttaata taaagtcatc ttttatttct tctattacat ctaatctatt
    40201 ttcaatttta gatttattta tcaaaggttc ttctacatat tttcttaaaa gtctacctcc
    40261 cattgctgta gaagttttgt caagtacatg taataatgaa ccttttttct tattccctct
    40321 tatagtttga gtaagttcta aattagttct agtaaacata tctagaacca tatattctga
    40381 tgaattgtat atatttatat tattaatgtt agatgttatt tgtttttgag tattgtatat
    40441 ataattcaga agaattgata agcttgactt tattagacct ttatcatcaa actttagttt
    40501 ttgtagataa acatctggaa aatattcttt taatatattt atatccaaat agttatcact
    40561 aaaactttca tttatgtata tattacttac agtagctata tctctaagct tttctataaa
    40621 gtctaaatca tttataatta tttcagttgg atggattttt gcaatttctt caattacctt
    40681 atcttcattt aaacatgttg cattagtttc tcctgtactt atatcaacat aagttagacc
    40741 tatattagta ccatccttat acaaagataa taaataatta ttctttttat tttcaagtaa
    40801 atttccatct aaaactgtac caggagtgat gacccttata acctctcttc taacaattcc
    40861 ttttgctgta gatgggtctt ccatttgttc acctattgct actttatatc cattttcaac
    40921 taattttgat atatatgaat tggctgagtg gaaaggaaca ccacacatag gagcacgttc
    40981 ttctaaacca caagcttttc ctgtcaatgc tatttcaaga gcttttgaag ctactaatgc
    41041 atcttcaaaa aacatttcat aaaaatctcc aagtctaaaa aacagtatac agtctttata
    41101 tctatttttt acttcaagat actgtttcat cataggagtt aatttattca tatctatttg
    41161 cattatcaaa cctccttctt ttctaattaa atattatatc atagtagatg attattatta
    41221 acacaatata taaaattttg acatataact aaaaacaatc caaaatgtat actcacattt
    41281 tggattgcta agtttaatgc ttattaaata aaaatatttt tttttacaat aaagatatta
    41341 tttctttttt aagtttaatg atattttcaa ggttatcttc atttaacttt ctactatcta
    41401 taacaaattc tttctttact attgatggtt tttttgaaat aacataaatt ctgtttgata
    41461 gcattatagc ttcgtcaata tcatgagtta taagaagtat tgttgaattt acttttttct
    41521 taacatctaa aagccatttt tgcatggatg ttttagttaa tgaatcaagt gccccaaaag
    41581 gctcatctaa aagcattatg tcattagaat ttataaaagt tctcaagaag ttagctctct
    41641 gtctcattcc tccagaaagt tctgaaggat atttatcttc atatccgctt aatccaaaca
    41701 cctcaaaata aggttttacc attgacctag ctttactctt tttttctttt tttaaaatta
    41761 gtggtagtga cacattatct attatagttt tatatggcaa gagtaaatct ttttgataca
    41821 tataactata cttaccattt atattcactt tgccactatc ataatctgta agtttagtta
    41881 taatattaaa aatagtactt tttccacatc cacttggccc taatatagaa acaaactcac
    41941 cttcataaac atcaatactt atatctttta aaacttcaat atctttataa gtttttgata
    42001 cattttctat agatactttt acttttttat tgtggtaaaa attcatttgt gtaagcatca
    42061 cttgccttca tatccttatc tattaattta tattctttta agaatgatgt atagttgttc
    42121 catacactat ctttcatttc tccccatcgt ggtgcatcat ctttgtactt gcttgctaaa
    42181 tattcttgac tctttaaagc tagtttttca tctacttcag gtgcatgttt tactaaaatt
    42241 tttgctgatt cttctggatt ttttattgca tattcataac cttttgttgt agcttttaag
    42301 aattttttag caagctctgg attattttta agcacagttt cattagaaat tataagtggt
    42361 gtataataat ccaatctctc atctaaatct tttactggta taaagtttaa gtcatatcca
    42421 attaaatcag ctttaactgc atcccaacct tcaaatatcc atgcaaaatc tacagttttc
    42481 atagctgcaa agaaatcatc ttgaccagta ttaactatct ttaacttatt aaaatcagct
    42541 ccatttttct tcataactgc tttaaaaaca gcttcttctg atggagagcc ccaaccacca
    42601 taagtttttc cttcaaaatc tttagctgtt gttatattct tttcttttgg tgatgcaaac
    42661 ccagaagtat tatgttgtat aacagttgct acagctttta ttggaagtgg atcttcacta
    42721 gtctttgcat aagtaacttg ttcttgatag cttataccaa agtcagcttt tcctgttgct
    42781 actaaagttt ctgctccact ttcaggtggt tgtactattt caacatccaa accttcttct
    42841 ttatagtaac ccttatcaag tgctacaaat aatccagtat gatttgtatt tggtgtccaa
    42901 tcaagcacca tagttacttt tttagaagaa gtatctttat cattgttttt gtctttattg
    42961 ttatttgaag aacatccagt tattgttgcc aatgtaaaaa cacttactaa acctaatatt
    43021 cctaactttt taaaattcat aattgcctcc ctcaaatacc tttaatctat taatctatgt
    43081 cttataacaa ctttttttac agcctgtaca attcctacaa acattaaact aaatataact
    43141 actaatatag tagatgcaaa tactttatca agtgcatatg cactttttga cctaagcata
    43201 taaacaccaa gtcctttcgt tccacctagc cattctgcaa cagttgctgc cattacagca
    43261 tacgttgcag atattttaag tccagaaaaa aatttatcca ttgccatagg aaatttaagg
    43321 tgaatgaatg tattaacttt atttgagtcc atagtcttaa ataaatttaa ataatcttta
    43381 tcaatattct caatgccatc tacaaaactt attaatatag gaaaaaaaca agtaagcatt
    43441 accatcaata cttttggcat tgttccaaat ccaaaccata tcataaagag tggtgctata
    43501 attattgtag gtatcatctg tgtaaccaac ataataggat aaagacattt ttttattatt
    43561 gatacaaaat ccatcaatat tccaattacc aatgatatta taattgcgac tataaaacca
    43621 agtattgctt ctcctatagt aaccacagca tgtatggata aattttgata atctttaaaa
    43681 aacacattaa ttatatctac tggtgtgggt agtatatact gaggaacttc taaaactcct
    43741 accatagatt gccaaagaat aagtataaac aaaaatgttg ctattggata tatactatct
    43801 ttgactttat ctatgatttc taagtttttc atctatagtc agacctccag ctttttcatc
    43861 tactctagct actgttatga ctctttcaca tccaagatta aaagggattt tatgtacctt
    43921 ttttaataat tcaaaaactt catcaaaatc accttcaaca gtagtgctca ttgctcctat
    43981 ttcacattta agaccacttt tttcaatttc agcaatacaa gcatctacta ctttatacat
    44041 ctcttcttca cctttgtaag gtcttagtgg cattactgct atgtctgcga ttaccattta
    44101 aatcactcct ttaaaaataa ttaataccta ctaggtatat tttgtttttt attaaaaaat
    44161 tttattacta aaaagatatt atatttaaat aaaagaaaag tcttatccaa aataggataa
    44221 gacttatttt tatcttaact ggtctcccta cactggcatt atccaaacag gttcaaaggg
    44281 tcgagataaa atctcctctc agcacattag ctccccgaaa tatattatat cttttctact
    44341 tgattatact acacttatca tattttaaca aattttttat ttatattaga tattttatcc
    44401 gttcaaaaat atctaatata aattgtacat tattacacca aataaattat cttaaaatgg
    44461 taatttatca acatcttcca aaactagatt aactgaattt tctagttttt attttgctat
    44521 ttcaagcata tttggatgta tatcaattcc atacaaatat tgtgctaaat ttctgttttc
    44581 actcatctaa tttgcaatcg ttacaaatta cagattagaa atagctttta gactctactt
    44641 atctttatct acaaaaaatc cttcaataaa ttcattaata atattcagta atctaaaaat
    44701 aaacctctat ctagattttt aagatacaag ccttttagga agtatctttt gtgataatat
    44761 aaaaattact catcattatc atcaaaatcc tcagcaacca acattttaga taagaatcaa
    44821 actctataat ataattattt tatccaattt atttttgaga aataaaatat ttttttaatt
    44881 tttaaatttt ttaatatgca ccttgaaaaa agaaacgttt tcctatatta tggtaatagt
    44941 agaataaaac taaataggca aaactagaga aatttagtga cgcaaagcta tagggactaa
    45001 gacttatgaa atgagttatg tcagccagtt gccaaagaga tattttcttt ttgtttttat
    45061 gaatgttttt tagggggata tatgatatat gtttatggat aaaatggata gatgtacaca
    45121 tatactaact gcatatatat gcagttcacg cgattactgc aattttatag atacacaatt
    45181 aaatgatttt atactagaat atggagagaa tgtggtagaa tcttgtttgc atcaagtgat
    45241 ggtattggta agcagatata attaaagaaa ttttattttc tagaaaaccc tttttagttt
    45301 tatctacgtt ttataattca ttaaagaact aattaaaata agcttcatta tatatttttc
    45361 ataaagtaaa cagttgagtt tatctcatat actgtttacc ccaattacat aattctaata
    45421 atatagattc taatgattta ccacgtttag tagacaaata ttcaactttt ggaggaatag
    45481 tcggataaga aatcctctta ataagtccat ctctttcaag atactttaat tcttgtgaca
    45541 gtatcttatg acttatatga acaacttctt tttttaattg actgtaacgt attggctctt
    45601 gttttaaaat atgccataaa ataattgccc tccatttact tcctatcaca gtcatggtaa
    45661 aaccaattga acaattaaaa tctttttgtc tttcttcaat atttggaaat tcttcaaaat
    45721 tattatctat atccatctca atcctctctt tcaaaatagt aagtatctaa ctaaaaagtg
    45781 cattcttgtt tagcgtacta attcgtaata taatcttgat tgtagtatag agccttacat
    45841 aatactactt ttttagatgt atatgtttaa actttaatat agacatatgt tattttatta
    45901 attttattta aacagataat aataaataat aatttatctc aagttttcta tgtagataaa
    45961 ctaatctaat gtttagaaag gattatataa tatgaataaa aaatttcgtc tttatcaagt
    46021 tgactcatta caaaagaaaa atttacaggt aatccagctg gtgtaattac aaatgctgat
    46081 ggcttatctg aatcacaaat gcaaaaaata gcaagagaat taaataattc agaaactgct
    46141 tttattttca ataacttggc taaaaatcat caagaaaatt atgatgtaca tatcagattt
    46201 tttacactaa ctaatgaggt tcctatatgt ggtcatgcta ctattgctgc ccattatgtt
    46261 agagcagtag aaaaccaatt caataacaaa acagtatttc aaaaaactag tgctggaata
    46321 ttaccagttg atattataaa aaaagataat gattatgaaa taattatgac acaaggaaaa
    46381 attgaagtat ctccaccgtt acaacaaacc tatcaaaaaa gattacttaa tgcatttggt
    46441 attttaaagg aagatattcg tacagattgt cctattgcca tatcatctac aggacattca
    46501 aaagttatga ttggaataaa ggaattatca acattaaata gtttatctcc aaatttatat
    46561 gaattatcga aaataagtca agaaataaaa tgtaatggat attatatttt tacattacat
    46621 aataaagaaa ctctacaagt tcatggaaga atgtttgctc ctgcaattgg tatttcagaa
    46681 gaccctgtta caggaaatgc taatggaccc ttaggtgcgt accttgtaca ttataaagta
    46741 atacctacac ccaacacaga gtttatattt gaagcagttc aaggagaaac aataaaacgc
    46801 aaaggcaaga tgttagtaaa agtaattatt ttagataata aaccagttga agtaaaaata
    46861 attggaaaag ctgtaattgc attctcaaca aacatagaaa tctaattata gattccttct
    46921 aagtaaattt ttgaactttt taatactaat ttaataacaa actaatttat atacaatcaa
    46981 attaattttt ttattatttg ttaatatata tttatcatta tattatataa taatatagat
    47041 agttactata tcttataatt agataaatca taattatata ttattgttaa aactcaatta
    47101 tataattttt aataatatta ttttaggagg taaaaatgat aaacgatatt aaaaataaat
    47161 tcaaaaatta caaaccatat ataaatggat acaagaatat gaagagagca tctgttttaa
    47221 ttccaatagt agaaataaat aacacacact atatattatt tgaagttcgc tcaaaaaatt
    47281 tgaagcatca acctagtgaa atttcttttc caggtggtaa aatagaatca ggtgagactc
    47341 catatgaagc tgttattaga gaaacttgtg aggaacttgg aacttttagt gacaatatag
    47401 aagtaatatc aagtcttgac ctccttataa caccagtaaa gtttatcata catccatact
    47461 taggatatat aaaaaatatt aataatttaa atataaacaa ggatgaagtt gaccatactt
    47521 ttttggttcc tataaaatat cttttagaga atcctccaaa tacttatagt aatactgtaa
    47581 aagtttttcc agacgaaaat ctaccatatg gttcaattcc aaaccaaaaa gattataaat
    47641 ttgaaagtgg aagttatcct attctgtttt ataaatataa agattatgta atttggggaa
    47701 tgacagcaaa aatactagaa aactttttaa attttttatc agaataacac tcataataaa
    47761 tcatcaaaac ttttacataa gaaatttata aaagtttcta aatt
//
LOCUS       DAEPID010000028        44429 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.028, whole genome shotgun sequence.
ACCESSION   DAEPID010000028 DAEPID010000000
VERSION     DAEPID010000028.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 44429)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 44429)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..44429
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.028"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            complement(355..1398)
                     /locus_tag="KR257_001682"
     CDS             complement(355..1398)
                     /locus_tag="KR257_001682"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418635.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SPFH/Band 7/PHB domain protein"
                     /protein_id="HBH0030386.1"
                     /translation="MGTKIVLSIVLIVVVVAISLTCIRVIKQSKVGIIMRLGKFQKVA
                     ETGVHFLIPFLDKMAYVIDLREIVIDFPPQPVITKDNVTMQIDTVVYYKVTDPVRYVF
                     EIANPIAAIENLTATTLRNIIGELDLDETLTSRDIINVKMRTILDEATDKWGIKVNRV
                     ELKNIMPPQDIQVAMEKQMRAERERREAILQAEGNKSAAILQAEGEKQSAILTAEAKK
                     EAMVRVAEGEKESAILVAEGEAEAIRQTAIAKAQGEAEMIKRTQMATAEGLKLVFSAM
                     KEADIDNNILALKSMEALEKMAEGKSTKLVLPSEAVNFLGTFKGIKEVMSDDNKEVLD
                     IKEVLNDNESLKK"
     gene            complement(1419..1865)
                     /locus_tag="KR257_001683"
     CDS             complement(1419..1865)
                     /locus_tag="KR257_001683"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437174.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NfeD family protein"
                     /protein_id="HBH0030387.1"
                     /translation="MKLIWLIVAVLFGIAEMLTPSLTLIWFSVGAVILIFLSSFIESI
                     FLQILIFAVISIAMLVVATKKIVKKDKGYKSNTNLQAMMSKKGIVTEEISPNNTGLVV
                     VEHETWTAISIDGEKIEKGSTVEVLKIEGVKLVVKKVDATVNVTNQ"
     gene            complement(2043..3623)
                     /locus_tag="KR257_001684"
     CDS             complement(2043..3623)
                     /locus_tag="KR257_001684"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418630.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional ADP-dependent NAD(P)H-hydrate
                     dehydratase/NAD(P)H-hydrate epimerase"
                     /protein_id="HBH0030388.1"
                     /translation="MLIGTSKLSRNVDTACVEEVGIPMIVLMENAVISAMKNMDIDMY
                     NSYTVVCGVGNNGGDGLGIARHLNTYGKEVNVFLVGNLEKLSECSKINYNVLLNMGIN
                     IININKNDLSEKNYGEENEVDKIIKVEKQNIIKNKNLTIFKDRVSKSDVVVDAIFGTG
                     LKRDITGIFKEVIDIVNDNSKNTYSIDIPSGIDSDNGNVLGTCIRANKTISFEFYKRG
                     FLNYDTSALIGDVVVEKIGVPDFITRKYHDEEFITDKTFVKNNIRRRDKHGFKSDFGK
                     VSIVAGSKGFYGASFIATESAVKSGSGLVTLISSEDVQEKVSIRLTEAMTLNFEEERL
                     NKLLNSSDAIGFGPGMGDNSQTFDKLLKIVENSNCPIVLDADGLNVMKDRCYKFLEWK
                     NRFVITPHLGEMARLTGDSIGYIREHRVDVAKEFAQKYNLVVLLKGYQTVITDGKKTY
                     INPTGNSCMATGGMGDCLLGMITSFIGQGMDILEATVSGAYIHGYIGDKLSKAMYTVN
                     ATDLISNISLTMKELLDI"
     gene            4422..5324
                     /locus_tag="KR257_001685"
     CDS             4422..5324
                     /locus_tag="KR257_001685"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009905178.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBH0030389.1"
                     /translation="MSGIISVMTQSLILSIMALGVYITYKILDFPDMSADGSYTMGAS
                     IVAFSLTNGISPVVATLMAILCGCTAGLVTGILHIKFKISNLLSGILVMGMLYSINLR
                     IMGKSNIPLFSFKHLFNGEISPIVLALAFVFICKVLLDLFLKTGLGYTLKGVGDNSQM
                     IKSLGINIGSIKILGLMISNGLIALSGSLMAQFLGFSDVNMGIGTLVLGIASIIIGIT
                     LFKKFTFIKDTTAIIVGSFIYQFTIYFAMSLGMLSTDLKLITAIVIIAFLATGNLNIS
                     LKKNKCKASTKNKSEKRGVVDVTN"
     gene            5311..6066
                     /locus_tag="KR257_001686"
     CDS             5311..6066
                     /locus_tag="KR257_001686"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003399531.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="HBH0030390.1"
                     /translation="MLQIKNLSKSFPNPYGEPNTIFENLSIDIEDGEFVSIIGSNGTG
                     KSTLLNIISGLIKESSGQITLDSTTITNLAEYKRTQIVSRVFQDPSLGTCPSMTVREN
                     LSLALNKGKLLNLKKCLRHKTNDLEHLLEGISLDLKKYLDIKVQYLSGGQRQSLSLIM
                     SSLASPKVLLLDEHTAALDPKTSNEVIELTDKIVREKNITTLMVTHNLKHALQYGDRL
                     IMLHKGEVVLDVKDKEKKDLTVEEILEKFEYAV"
     gene            6163..7200
                     /locus_tag="KR257_001687"
     CDS             6163..7200
                     /locus_tag="KR257_001687"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429748.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="HBH0030391.1"
                     /translation="MIKSKKILSLIIAGVLGVSMLTGCSQNDGSNASNENKETDSKKQ
                     KNIGITQLVEHPSLDKAKKGFIKALEDKGYKDGDNIKIDFQNAQNDMPTTQSIASKFV
                     SDKKDLIYAISTPSAQAAYNATKDIPIIMTAVTDPVEAGLVKSLEKPGGNVSGTSDYL
                     SIDKTLELVKTLTPKAKKIGVIYNTSEVNSKIQVDSLHDYAKKNNYEVVEKGISSSSE
                     VNQAISSLVGKIDVLYVPTDNLIVSSMPIVSKVANENKIPIIASEEGSVSSGALACCG
                     IDYEKLGYKAGELAIEVLEGKSVGDIPVTTLDETEIIINEDTLKALDMQKLSADNIKY
                     IKSDENAKSTK"
     gene            8009..8911
                     /locus_tag="KR257_001688"
     CDS             8009..8911
                     /locus_tag="KR257_001688"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009905178.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBH0030392.1"
                     /translation="MSGIISVMTQSLILSIMALGVYITYKILDFPDMSADGSYTMGAS
                     IVAFSLTNGISPVVATLMAILCGCTAGLVTGILHIKFKISNLLSGILVMGMLYSINLR
                     IMGKSNIPLFSFKHLFNGEISPIVLALAFVFICKVLLDLFLKTGLGYTLKGVGDNSQM
                     IKSLGINIGSIKILGLMISNGLIALSGSLMAQFLGFSDVNMGIGTLVLGIASIIIGIT
                     LFKKFTFIKDTTAIIVGSFIYQFTIYFAMSLGMLSTDLKLITAIVIISFLATGNLNIS
                     LKKNKCKASTKNKSEKRGVVDVTN"
     gene            8898..9653
                     /locus_tag="KR257_001689"
     CDS             8898..9653
                     /locus_tag="KR257_001689"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892814.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="HBH0030393.1"
                     /translation="MLQIKNLSKSFPNPYGEPNTIFENLSIDIEDGEFVSIIGSNGTG
                     KSTLLNIISGLIKESSGQVLLNKHNLSNLAEHRRTQIVSRVFQDPSLGTCPSMTVREN
                     LSLALNKGKLLNLRKCLRYKRDFLENLLEGVSLDLKKYLDVQVKFLSGGQRQSLSLIM
                     SCLTNPSVLLLDEHTAALDPKTSNEVIELTNKIVREKNITTLMVTHNLKHALHYGDRL
                     IMLHKGEVVLDVKGKEKEQLTVEEILEKFEYAV"
     gene            9784..10806
                     /locus_tag="KR257_001690"
     CDS             9784..10806
                     /locus_tag="KR257_001690"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437194.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="HBH0030394.1"
                     /translation="MINKKRLASLILAGALSISMLTGCSQGGDSGNSKQESNSKGKEV
                     KKIGITQLVEHPALDATRTGFVKALEKNGFKDGENIDIDFQNAQNDMPTTQSIASKFA
                     SDKKDLIFAISTPSAQAAFNATKDIPILITAVSDPVAAGLVKTLEKPGTNVSGTSDFV
                     SVDKGLELLKIFAPKAKTIGVMYNTSEVNSKVQVDALKEYASKNGFKVVEKGITTSNE
                     VNQGISSLVGKIDVLYVPTDNLVASSMPIVSKIATENKIPVIAAESGPVEKGALACQG
                     INYEKLGYKTGEMAVKILNGESVSDMPVATSDDTDIIVNEDILKALGMEKPSNENISY
                     VKTKQE"
     gene            complement(10970..11527)
                     /locus_tag="KR257_001691"
     CDS             complement(10970..11527)
                     /locus_tag="KR257_001691"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888695.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sugar O-acetyltransferase"
                     /protein_id="HBH0030395.1"
                     /translation="MTEKEKMLSGKGYYANDELLVKEREYCKKLTRLFNNTLEDEYEK
                     REDILRQLFGSVGKQINVEQNIRCDYGYNIHVGENFFANYDCIFLDVCKIEIGDNVML
                     APNVQIYTAYHPIDAQLRNSGIEYGSPVKIGDNVWIGGGVIITPGITIGDNVVIGAGS
                     VVTKDIPPNTVAVGNPCRVIKKIEE"
     gene            complement(11533..12609)
                     /locus_tag="KR257_001692"
     CDS             complement(11533..12609)
                     /locus_tag="KR257_001692"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004453580.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sulfate/molybdate ABC transporter ATP-binding
                     protein"
                     /protein_id="HBH0030396.1"
                     /translation="MSLYVDIEKDLSSFKLKVEIKQEKGTLGFLGESGSGKSMTLKCI
                     AGLEKPTRGKIVLNDRVLFDSEKKINLSTQDRKVGFLFQNYALFPHMTVSQNIELGLL
                     KLSKSEKKEIVARYLDILKLNGFEGRYPWQLSGGQQQRVALARALATSPDILLLDEPF
                     SALDHHLRSNMEKELMNMLKDYKGDILFVTHDIEEAYRVCDDIIVYNKGEGLPKRPKK
                     ELFESPKYLIEAKITGCKNISKLNRLDKNTIYATDWGCELTLNREIGDNIEYVGIREH
                     HIKVLDSNEDLNEKLCFELINIVENPFTYTIYVRKTDLSNECVPIQIELEKSKMRFKK
                     GDRIYLDFPQEYLFCFRYNYNKKE"
     gene            complement(12610..13293)
                     /gene="modB"
                     /locus_tag="KR257_001693"
     CDS             complement(12610..13293)
                     /gene="modB"
                     /locus_tag="KR257_001693"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009905174.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="molybdate ABC transporter permease subunit"
                     /protein_id="HBH0030397.1"
                     /translation="MGTDWSPLWISLKTSILSTIITFVIGIFVSYIMANYRGKWKGLI
                     DGLFTLPLILPPTVVGFFLLLLCGKNGFIGKFLLNFDRTLIFSWTATVISAVVVSFPM
                     MYRTSRSAFEQIDNNMLSAARTLGLNEWKVFFKIAVPLAWPGIIGGLVLSFARALGEF
                     GATLMIAGNIPGKTQTMPIAIFFAVEGGDMNKAMMWVMIIVAISIAMILLLNYWSEFQ
                     QKIIGKRCG"
     gene            complement(13442..14254)
                     /gene="modA"
                     /locus_tag="KR257_001694"
     CDS             complement(13442..14254)
                     /gene="modA"
                     /locus_tag="KR257_001694"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888684.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="molybdate ABC transporter substrate-binding
                     protein"
                     /protein_id="HBH0030398.1"
                     /translation="MKKILGILGLVACLTLGTVGCNSNEDKKDDGKQEKTTKSSDSVE
                     LNISAAASLKEAMAKIEEEYKKVDSNVKLTVNYGASGSLQQQIEQGAPCDLFISAGQK
                     QMKALDEEKLLVSDTMKDLVKNDLVLISSADSSVSGMEDLTTDKVKKIAVGEAESVPA
                     GKYADEVLTNLNLKDKLKDKLVFAKDVKEVLAWVQSGNADVGFVYFSDTVNNDKIKVV
                     EKTDEKTHSPITYPVSVIKASKNVDAAKKFEEFLLSESGQKIFEEFGYKKVE"
     gene            14447..15376
                     /locus_tag="KR257_001695"
     CDS             14447..15376
                     /locus_tag="KR257_001695"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728716.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HBH0030399.1"
                     /translation="MDSLSSLTPVEVAELLKITKNTVYELIKRGELPSYKVGKKIRVD
                     TKDVEEYINSQKTGKVKDTHFNNKNIDINNNFKIIISGQDVILDILARSVEKKLDGIS
                     TFRSYIGSYNALYELYNGRVSIASSHLWDFETDEYNSTFVKKLLPGIPCVLINLAYRM
                     QGFYVAKGNPKEITTWEDLTKPSITIVNREKGSGTRVLLDGKLRLLNFNGKHIKGYDN
                     EELSHLGVASTVSRGIADVGLGNEKAALQVNNIDFIPLHKERYDLVIKKEDLQNPVYQ
                     TIINIINSPEFKAELQGLGGYDLTDTGKTIAKV"
     gene            complement(15537..15986)
                     /locus_tag="KR257_001696"
     CDS             complement(15537..15986)
                     /locus_tag="KR257_001696"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895896.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0030400.1"
                     /translation="MKNKNNKDKNMLNIKVLRVLGVLLILFDYTGDTLNFYNFFAKPL
                     VSGNLYKTTGTDCIVFLLFIVECVYLVGRYILKVKINWSEIIENEKGNFINNLLVEKI
                     QEESNIVYNLLNSYVLPNIYKKARGLMFKTYHMLIYIKEKYYYVNIY"
     gene            complement(16189..17169)
                     /locus_tag="KR257_001697"
     CDS             complement(16189..17169)
                     /locus_tag="KR257_001697"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454199.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha/beta hydrolase"
                     /protein_id="HBH0030401.1"
                     /translation="MKNSFKNCISLRNKFIIISIVFLLILLIVSYIFGKLVYNSSVGL
                     EQLIKNEDIVKIFSERKDKPLEKLKNYKTSELMIQSSNNYKLESLFITSNIKTRDTMI
                     LVHGIGSSYYEMLKVAYRYLDKGYNVLVYNQRNTGNSGGDNYTFGLYERYDLDSLVKF
                     VKNKFPEGRLGVHGFSMGAGTAAMHSEINSKDDKVDFYILDSPYSEMKDAIRMGVLEK
                     RIPDILINYVVTCGDLYNKFKSGFWYSDVKPYESVEKSNVPILFIHGTKDTVCNYQNS
                     KKMYDLVKHDKKDLWLIEGIGHVDGFEHDSTVYFNKIFKFIDSNVLSDKS"
     gene            complement(17374..18234)
                     /locus_tag="KR257_001698"
     CDS             complement(17374..18234)
                     /locus_tag="KR257_001698"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012816064.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="protein-ADP-ribose hydrolase"
                     /protein_id="HBH0030402.1"
                     /translation="MAMKWRDYADDVNLFEDFDKTIKPLTDEQRRKNINTLIAYFSKE
                     VPSKIYNLSNDEIKPRDILRGLLNVYPPKEIAPEILNMLHNLLLIECEERELVDVNDI
                     EEVEEGIAIWRGNITNLRADAIVNAANNKLLGCLQPLHLCVDNEIHSCAGPRLREDCD
                     KIIKKQGHLEYTGDAKITRGYCLPAKFVVHTVGPIVSGGQPSKEQEKQLLHCYKSCLN
                     TIKEIDEIKNIVFCGISTGVFGYPKKEAANLAVSRVRLWLKENPEKNLKVVFNVFTEE
                     EEEKYRRIFK"
     gene            complement(18551..19879)
                     /locus_tag="KR257_001699"
     CDS             complement(18551..19879)
                     /locus_tag="KR257_001699"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010963854.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="6-phospho-alpha-glucosidase"
                     /protein_id="HBH0030403.1"
                     /translation="MEKFSVVIAGGGSTYTPEIILMLLDNLDRLPLRAIKLYDNDEER
                     QNKVAKACEILIKEKDPNIEYLATTCPKEAYTDVDFCLAHIRVGKLEMRELDEKIPLK
                     HGVVGQETCGPGGIAYGMRSIEGVLENIDYMEKYSPNCWMLNYSNPASIIAEAVRRLR
                     PNSRVINICDMPIGMEHNIARIAGLKSRKHMDIRYFGLNHFGWYTSIKDKKGNELLPK
                     LVEHIKEYGFINGEEGMKNDKKDSWFETNLFTKEIVKTDLTTIPSSYLKYYLFPDYVV
                     NHSDVNYTRANEVIDGREKEVFGSCALIEKQGHSKGSGLKIGIHAEFIVDLATALAFN
                     TQERMLLIVQNNGAIENIQDDAMVEIPCIVGKDGYEPLSIGKIPTFQKGLIEQQLAVE
                     KLVVDAWIEKSYNKLWQALMLSKTVPSATVAKELLDDLIEANKNYWPKLN"
     gene            complement(20027..20356)
                     /locus_tag="KR257_001700"
     CDS             complement(20027..20356)
                     /locus_tag="KR257_001700"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004453589.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS lactose/cellobiose transporter subunit IIA"
                     /protein_id="HBH0030404.1"
                     /translation="MVPEMEEKVFSIISEAGDAKSDVMMSLKEIKKGDYNKAKHLLNS
                     ASEKIQTASKHHLELLSNAMNSEDSGTDFLVVHSEDHYSNALFAHSLVSELVDIFEMM
                     DPRINKN"
     gene            complement(20380..21669)
                     /locus_tag="KR257_001701"
     CDS             complement(20380..21669)
                     /locus_tag="KR257_001701"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892810.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIC"
                     /protein_id="HBH0030405.1"
                     /translation="MEALQNNLRRFLLPIAQKIEKQRHLQAIKEGMISITPIIIVGSL
                     SMLFMALNNMLPEGSAKTLLSENMDTLLIPNKFTMSLLSIYSAFFIAQALAKKYNLNH
                     VEIGMTAVVAQLVVCGQVVDGVLDTSYLDAQGLFVSILVALLVVDITKFMNDKNLVIR
                     FPKEVPSVVNKSFRNLTPMIVCIMLFTAIAAITKNVSGQPLPAIIMNFLAPAISSVDN
                     VFAVTIILFITQLLWFFGLHGAAITSSIWMPIAATYMAENATLIAAGGDPKYVFTIGF
                     YYGFLQVTGSGITLGLVYLMSRSKCKSFNSMGKVVILPSLFGINEPVIFGTPIVMNPY
                     MFVPFVFGPVLVGALNFMALKVGLVGLPIAEPPGFLPPGVAAFLMTLDWKAIVLVFAS
                     IILMTLIYYPFFKIMEKEELNKNAELATTLDDDSFDF"
     gene            complement(21685..22011)
                     /locus_tag="KR257_001702"
     CDS             complement(21685..22011)
                     /locus_tag="KR257_001702"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004453591.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIB"
                     /protein_id="HBH0030406.1"
                     /translation="MNILLVCANGASTGVLVEKMKSFCSEHEKLKTKTINIEATSFEN
                     LKSYIEANDTDVVLVAPQIRFKEDDVVEACKNYKIAVGLIDTKHYGRMDAPSVMKSAI
                     ELYKNR"
     gene            complement(22146..22775)
                     /locus_tag="KR257_001703"
     CDS             complement(22146..22775)
                     /locus_tag="KR257_001703"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004453592.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0030407.1"
                     /translation="MQDKILRDKKANDPWARMTTRNGFSADEIISSFQKAIRRNMVEE
                     ACEFAYELYISSPELEDKLWRRILTISVEDIGMGDPSAVIIINNLNQVRKEYSYADGD
                     RPLFFIHAIRYLCACEKDRSSDLLKNIIIKGFAMGKVPEVMDVALDKHTYRGLEMGRD
                     SFHFLNEASIVIPEKEVDNDYKERYLKILEKYKQEEVIDTAFKFNHWQY"
     gene            complement(22991..25648)
                     /locus_tag="KR257_001704"
     CDS             complement(22991..25648)
                     /locus_tag="KR257_001704"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418584.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sigma 54-interacting transcriptional regulator"
                     /protein_id="HBH0030408.1"
                     /translation="MIYKKDKVMKVLESSYRENEKGITANQLSEKTGIARNNISTYLN
                     QLFNEGMVTKIKGRPVYYIPANLNLNKNELLDTQSELLGIKKGTKVENKIKKDSFETL
                     IGKEHSLRPIIEKCKVAMLYPTNGLHTIIYGETGVGKSMIARYMYDYSIDSGIRKNKA
                     PFVTFNCADYANNAQLLMGHIFGVEQGAYTGAESSRKGLLEIANGGILFLDEIHRLPA
                     EGQEMLFTFIDKGTFKRLGDATKERESKVLIICATTENPTSTLLDTFNRRIPMKIEIP
                     SLRDRTMIERMELVKNFFKEESKSISISIKVHKEIIKSLLLYDCKNNVGQLQNDIKLA
                     VANGYLRYKRDNKEPVYIEKKYFDKSINEVSDDYREKSIKADEVITHGIEYFVFTSLG
                     EEEVINYNDINIINAVNTNLNKSVEMNIADASLFNNVKFKSMCESIRQIIKEDEEIDI
                     SESIFKSMAIYIKSVLDKSSSTNNIDLNQIRRNNRSEFKTALKIVGIIENEFDLFLSI
                     ETVAYITLFIVQAKQDEQNKIVNNINIIVAMHGETTASSMVKAVGDIIGKCSAISFDM
                     KLDKSYDEVIVDFKNLINNIDNKDVLLFTDMGSLNSFDEIIKKEKKCGVRVIPMVTTL
                     TVLEAVQKANMGLPLNDVYNSITNTRKHYFGTNEIQNKENLSKTIIIASHVSEGVDNK
                     TRKILEEKMSRYLDGIDIISVPYKTEKDLSLNITKLKESSNIVAVINEQRINIRGIDY
                     ISKKDIDKDENINKLKNIIKISIGYDDVVEGLKTSLKSSNYNRIFKDIKYVSDELFLV
                     FNIEKKYDKVIGLMMHLAFMVDGLIGNTREIEKLDKEKTLDYHKSLSKIKDIVSQLDK
                     KYNIEINEKECYQILLILEYAEIIEKDYQ"
     gene            complement(26007..26951)
                     /locus_tag="KR257_001705"
     CDS             complement(26007..26951)
                     /locus_tag="KR257_001705"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009527644.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBH0030409.1"
                     /translation="MNREKILEIKNLKQYFHLDKSTTVKAVDDISFDIYKGEIFGLVG
                     ESGSGKSTTGKTIIRLHESTGGEVIYKGNCISDKKTYKFIKKDVNKSMQIIFQDSTSS
                     LNPRMTIADIISEPLKIQGICKNKTDRMNKVYEMLKLVGLDRSYANKYPSDFSGGQRQ
                     RIGIARALSVDPEFIIADEPIASLDVSIQAQIVNLFKKLQQEKNLTCLFIAHDLSMVR
                     HISDRIGVMYNGKLVELADSNELYNNPIHPYTKSLLSAIPVPDPRYAKSRNRIEYNSN
                     GYDCSNEKSLSWIEVSDGHFVYSSKSEINKYQQNLKVV"
     gene            complement(26944..27969)
                     /locus_tag="KR257_001706"
     CDS             complement(26944..27969)
                     /locus_tag="KR257_001706"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418581.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBH0030410.1"
                     /translation="MEHLLEVNNLSVSFKVEEGEVQAVRNVSFNLKKGETLAIVGESG
                     CGKSVLCKSLMRILPYNGYIKNGEVLLKSSDLVKKSEKEMEDIRGKNISMIFQDPMTS
                     LNPTISIGKQIAEAVIIHQGISKSEAKKRAIELIELVGIDNPEKRFKQFPHHFSGGMR
                     QRIVIAIALACNPDVLIADEPTTALDVTIQAQIIDLIKDLQHKIGLSIIFITHDLGVV
                     ATIADRIAVMYAGKIVEIGTVEDIFYDPRHPYTWGLLGSLPTLDSQDDYLYNIPGMPP
                     NLLNPPKGDAFAIRNKNALKIDYEKEPPMFKINDTHSAATWLLHPDAPEVDVPVRVNC
                     GRVISNE"
     gene            complement(28044..29612)
                     /locus_tag="KR257_001707"
     CDS             complement(28044..29612)
                     /locus_tag="KR257_001707"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004453597.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="HBH0030411.1"
                     /translation="MKLKKLKVLSLVMILSLMAGCSSGGDKDKKADTPKDGKVLVYGS
                     NDYTSINPALYEHGEINSLIFNGLTAHDENNKVVPCLAKDWKFDEATNTYTFNLRDDV
                     KWHDGEKFTANDVKFTIETIMNPDNASEIASNYEDITKIDVVNDNTIKITLKAPNTAM
                     LDYLTVGVLPKHALEGKDIATDEFNQKPIGTGPFKLEKWDKGQSITLVKNSDYFVKEP
                     GLDKVVFKIVPDDKAKAMQLKSGELDLAQITPKDMSNFEKDEKNFKVNIMKTADYRGI
                     LYNFNSKFFKDKKAKGLPNALSYAIDRKAIVDSVLLGHGVPAYSPLQMGPYNNPDIEK
                     FEYNPEKAKQEIEKLGWKLGSDGIYEKEGTKLAFEITAGESDQVRVDMAKICAQQLKE
                     IGVDAKAVVVTETDWANQDAHLIGWGSPFDPDDHTYKVFGTDKGANYSAYSNPTIDKI
                     LQKARETEDKDEKLKLYKQFQVEMTKDMPYTFIAYIDAIYVGKPNIKGLTPDTVLGHH
                     GVGVFWNIADWTIE"
     gene            complement(29725..30636)
                     /locus_tag="KR257_001708"
     CDS             complement(29725..30636)
                     /locus_tag="KR257_001708"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888669.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBH0030412.1"
                     /translation="MKPQYSDFEIVGENYILVAEDEHIETKKTLSKKIKELPYISIII
                     LSIIVIGSVFSSFIMTHEPTYMDLASSNLAPNKTFLFGTDSMGRDIYSMIWYGGKISL
                     FIGLFSTVISTVIGIVYGSISGSASELVDDAMMRFTEIILSIPSILIIIFVQAILGNS
                     NPVSMSIVIGITSWMNISKIVRTEVRQIKNSEYILAAKSMGGGFFYVLKQHLLPNFVA
                     SIMFMVVTNIGAAIGTESTLSFLGIGLPIEIVSWGSMLSLSEEALLSNRWWIILIPGI
                     FLVTTLVCITNIGNYIRKNNNKKSSNL"
     gene            complement(30620..31606)
                     /locus_tag="KR257_001709"
     CDS             complement(30620..31606)
                     /locus_tag="KR257_001709"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888668.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBH0030413.1"
                     /translation="MLKDILKKLLQFILVMFLLSFIVFYMARLAPGDPLISYYGDGVE
                     RMSTQEKENAMKKLGLDEPIYSQYIKWISNASKGEFGISFKYKQNVTSVINDVYINTI
                     ILGGSGYILTFVLALLLGIFCTLHEDKLIDRIICKLGTITNCIPSFWVALVLILIFSI
                     NLSILPSSGAYSMGEESSILSRISHLILPLTVLILSHLWYYTYMIRNKLLEEIREDYV
                     LLCKAKGLNNRTIVFKHCLRNIMPSYISIMAISIPHILGGTYVVEKVFSYPGLGTLCF
                     ESAKYHDYNMLLVLCLITGALVVFGNMLAQIINNKIDPRMKYDRGDTNEATI"
     gene            31966..32367
                     /locus_tag="KR257_001710"
     CDS             31966..32367
                     /locus_tag="KR257_001710"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004453602.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="winged helix-turn-helix transcriptional
                     regulator"
                     /protein_id="HBH0030414.1"
                     /translation="MLLKELYSKTMYTVEENFKENGLTHQQIIVIKLIAHNQELTISQ
                     LCDEMSLAKGTVSGIISRLEQIGYIEKFKKSNDKRNTYVKFTTTGFEFATNFKIKMQE
                     SFDDIFKNCDENELSDLVKNLRNILAKVKER"
     gene            32370..32768
                     /locus_tag="KR257_001711"
     CDS             32370..32768
                     /locus_tag="KR257_001711"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004453603.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TIGR03987 family protein"
                     /protein_id="HBH0030415.1"
                     /translation="MNYKLILAIVFITSALIFYTIGVFGERKAKILKKKHVIIFWLGF
                     IFDTLGTFTMSNIANSHTFEVKSALSQNLHSITGLLAIVLMLFHASWATFVLYKDDEE
                     KKKFFHKFSIVVWTIWLVPYFIGMFIGMAG"
     gene            complement(33218..33442)
                     /locus_tag="KR257_001712"
     CDS             complement(33218..33442)
                     /locus_tag="KR257_001712"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888660.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NifU family protein"
                     /protein_id="HBH0030416.1"
                     /translation="MREKVEKVLEEKIKPVLQRDGGDVELIDVNENGVVLVRLQGACS
                     GCPGATMTIKAIIENVLVSEVPGVTQVLGV"
     gene            complement(33477..34844)
                     /locus_tag="KR257_001713"
     CDS             complement(33477..34844)
                     /locus_tag="KR257_001713"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888658.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amidohydrolase"
                     /protein_id="HBH0030417.1"
                     /translation="MKEYIINNVEEIREELIDLSKKIWENPELAFEEKYASSIQKEYL
                     KSKGFKIEEVENLPTGFIASFGEGKPVIGILGEYDALPELSQCVSAERKPLVEGKAGH
                     GCGHNLLGVAGVGAVVSIKKLIEENKFNGTIKYFGCPAEEEGGGKTAMCINGCFDDVD
                     CAFTWHPFDINAPWRGGSLANLSVKFKFKGITAHAAQAPHNGRSALDAVEIMNVGANY
                     LREHVIDSIRMHYVITNGGGRPNVVPGFAESWYFIRGKKAKDAEHVLDRLIKVAQGAA
                     MMTETEMEYKVTDGIYDYIPNQCLTDLVYDNMVFVGCPKNTPEEEEFAKKLCDTLTRE
                     ERLGVATSLQNDKSIVESYIHKEIVDGDKDKGLAGSTDVGDVSYVIPVAQFAMAAWPV
                     GIASHTWQSCSSAGSNIGFSAMINSAKVLACSAYDVFMDTKIIDEAKIEFDKSLDGQK
                     FKPLV"
     gene            complement(34928..36463)
                     /locus_tag="KR257_001714"
     CDS             complement(34928..36463)
                     /locus_tag="KR257_001714"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728720.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0030418.1"
                     /translation="MLNNLSNININENNLIKNQYSISLLKECLNCKVIDEREVYNIQQ
                     EISLILMDLIKKYTNGQSTSVKTEVAEKLLISIWYAIDAYINKLGDIEKRVVELTAKN
                     VKKVYLGGIEILEEELVRLKDFYKLMMSRKLDTNSIAYNDTLMELSSFFKSYIVKFEA
                     QDVPVSIDYPLALDDMDVKGIYYVKNYIESIDIENRFCNLFKKKDREKLFYDYGVTYK
                     IDCDAILVNLFELIINNCIFSTILGNEVTNLEISKYEYEFLEKQFKNMYNNITEDKVI
                     DSEESNIIELIEVDDSFNTEVDSNLDYNDFEEINREIRINKKITLLLMEAIEVLIKRL
                     SIEDEDVIRYIKKYEKIFIESVLSSIKSNTFKSMVTVSKNKKEHLEDYIVDDESKLDD
                     ESFREIFNEILDSTSIIEKIRIIKENINAKKDFIDILESECLFGEEYLMLFASLSELE
                     LAILGSVVFYEDIRMREINILEFMLNEKTETTLWKIEYIKFMKRQSEDKIYSIEEHMN
                     KIN"
     gene            complement(36486..36920)
                     /locus_tag="KR257_001715"
     CDS             complement(36486..36920)
                     /locus_tag="KR257_001715"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902196.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0030419.1"
                     /translation="MISPIILSSINQNLKEIERNELLETNIESGDYGLALSESDVKDI
                     INSRDNTLKGYGRIELDIKVTKQLIENIYTSQYTNVDNYLEAINDMQEIFYYLKNETD
                     DKICDDEIIEILGEFYEKFSGNMDNVRGEADEFAKKFKFGEV"
     gene            complement(37180..38091)
                     /locus_tag="KR257_001716"
     CDS             complement(37180..38091)
                     /locus_tag="KR257_001716"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004453609.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CGNR zinc finger domain-containing protein"
                     /protein_id="HBH0030420.1"
                     /translation="MNKKIELIGNFASDWIRYSDYEYKITEEDELYIVPTEDAVFTMY
                     NPFDVADDIIVDIIRIGQEALQDISKETKEMKLKKEVLEFVKKYGLLGLIYSSVYNRD
                     IVGEERVLMIEKNYITKENILSTDEYVNMFIPFASDEDVYFKKYRRGIDVSKREESPK
                     FFGKRPLILDLVFSKFYTEQLDWIVSFAKDMCKHFNQICVYKNTSNLLTESVTIMSGG
                     FNPQKIGFSISQLDKPIIAWEFDSLKTAIETIYAFAITSEPSSLNKCKYCGKIYIPTN
                     SKSQYCSPSCRNCSNVKKSRSRAKKDK"
     gene            38387..38740
                     /locus_tag="KR257_001717"
     CDS             38387..38740
                     /locus_tag="KR257_001717"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418555.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GIY-YIG nuclease family protein"
                     /protein_id="HBH0030421.1"
                     /translation="MDRKRELKQLYKEMKFDTGVFIIKNDITKKIYLGKSNDIKSKFN
                     SLKFQLGAGSCMIKELNNEWKKYGEKAFTFEVLELIKHDDNKTEKDYLEELDILEMVW
                     LEKLKEDNTYEIYSI"
     gene            complement(38959..39900)
                     /locus_tag="KR257_001718"
     CDS             complement(38959..39900)
                     /locus_tag="KR257_001718"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454223.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell wall-binding protein Cwp25"
                     /protein_id="HBH0030422.1"
                     /translation="MRISKKVLALGISALLLSVSFPTSINALDKIENIQGVDKYETAG
                     LISDKQDFTTAVLINADSTMVDGIAASGLAGVNNAAILLTNKDDIPEATLQRLNRVTK
                     IYVIGGENSISKDVEKMLLMRRMQVIRIDGVDRVDTSYKIAGEIEKIKNSDKMFLVNG
                     FKDEADAVSVASVAYRDGAPIILTKDIPSAEEDTDLDPWFGVSPVPVYAIGGESTLSD
                     YIVSRYRATRIGGVDRYQTNKNVIEKFYNGAKEFYITSGDDLVYALVASPLAKNAPVV
                     LVSNKSDKSILSGASKVTAIGISDKSIIEQCLDAVKK"
     gene            complement(40001..41236)
                     /locus_tag="KR257_001719"
     CDS             complement(40001..41236)
                     /locus_tag="KR257_001719"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888653.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase family 4 protein"
                     /protein_id="HBH0030423.1"
                     /translation="MKILHIITQKPNSTGSGIYLSGMIKGFEKIGHKQAVIAGIDVND
                     DVNCFPSEVSFYPVKYNCGELNFPVVGMSDSMPYESTRYKDLNIDMINRLKYQFKVNI
                     DKAMNDFKPELIICHHLYLLTAFVREMVKDIKVMSICHGTCLRQLNTIDLEKEYIIAN
                     IRKLDLIFALHENQKYDIIKTFGVSQSKVVVIGSGYNDDIFYNKNYKIKDDKIKIVFA
                     GKICKSKGLIPFIKAISKLKYSKDLIEVNFAGTGSDIESYNEIVKLASKSPFKMNFLG
                     KLEQRDLAELFNRSQIFVLPSFYEGLPVVVLEALSCGTDVITTDILGVKEWIGSEINN
                     SGKIEYVSLPFMEKEGIPKDEELYDFENNLYNAIDSKIQSLLNNSNKKTSVDMSKKTW
                     DGLAYRINEVILMDELCLI"
     gene            complement(41280..42134)
                     /locus_tag="KR257_001720"
     CDS             complement(41280..42134)
                     /locus_tag="KR257_001720"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423488.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0030424.1"
                     /translation="MALNIRNYSLLCNQGTAKFNEDVVGINPFGAWVLDGATGLNGKN
                     LVSTESDARWYVQWWNRYLYKNINKEESLKSIINTGIIEVKKEYELRLNGFKVEKLDL
                     PSSSIVVVKFHENKVEYFLLGDCALFIKNGDSKVIKDRSICKFDNTVFDEMSKLSNLE
                     EMAFDEIRTSVMDTIVSNRLKKNTKEGYWILDFDEEAVENSIYGYIEIKKDFQLMLTS
                     DGFTSACDRYNLIKEEELIRIAEKFGIGYIHNKVRDFEDNDYKAVKVPRFKVKDDSSC
                     LYLDIYND"
     gene            complement(42262..43437)
                     /locus_tag="KR257_001721"
     CDS             complement(42262..43437)
                     /locus_tag="KR257_001721"
                     /EC_number="2.1.2.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860970.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphoribosylaminoimidazolecarboxamide
                     formyltransferase"
                     /protein_id="HBH0030425.1"
                     /translation="MARELELKYGCNPNQKPSKIYMKNGELPIEVLNGKPGYINFLDA
                     FNSWQLVKELKEATGLPAATSFKHVSPAGAAVGVPLSDTLKQIYFVDDLELSPLACAY
                     AMARGADRMSSYGDFIALSDVCDKETATIIAREVSDGIIAPGYTDEALEILKGKRKGN
                     YNIVKIDENYTPEPIETKDVYGITFEQGRNEILINEDLLKDIPTDNKIFTDSAKRDLI
                     IALITLKYTQSNSVCYAKDGQVIGVGAGQQSRIHCTRLAGNKADTWYLRQHPKVLNLK
                     FKKDIGRPDRDNTIDVYLSDDYMDVLADGIWQNFFEEKPEPLTGEGKRAWLKTLTGVA
                     LGSDAFFPFGDNIERAKRSGVSFIAQPGGSIRDDNVILTCNKYNIVMAFTKNRLFHH"
     gene            complement(43536..44420)
                     /locus_tag="KR257_001722"
     CDS             complement(43536..44420)
                     /locus_tag="KR257_001722"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888650.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="fumarylacetoacetate hydrolase family protein"
                     /protein_id="HBH0030426.1"
                     /translation="MKFVTFCSSNEEKIGVFNSETNSIYEINSLGLSKLYTDMNDFIE
                     NVSTGDLEKIKNNSFENAKCYKLEEVKLCSPIVRPKKDIICLGLNYKDHVNEIPDGVI
                     KNVVMPDYPIYFSKRADKIIGVDDKISLHGDLVEKLDYESELAVIIGKEGINISKEDA
                     YEYIFGYTIVNDISERALQDKHVQWFRGKSLDTHTSMGPCIVHKEEFEHPLKLDISSV
                     VNGEVRQDSNTEYFIFDIPTIINDLSRGMTLKPGDIISTGTPAGVAMGMNPQVYLKHG
                     DIVECKVEGIGVLKNIVD"
BASE COUNT        14615 a         7606 c         4891 g        17317 t
ORIGIN      
        1 ttctttgtct ataatttaaa caaaaggata taaactttta aattatttat tagttttctt
       61 agtattaatg tttatatttt tataaatata tattaataat ataaatagac taactaaaac
      121 catgcttatt tgctatatgt tttatattat attatataac actttttaca ttagtaaagg
      181 ataaattgta taaagattct gttaatttat ttttataatt tcatctttct aataaaaaca
      241 aagaagaaga cttaaaaatt tataagtcct cttcttttca acgtgcattt ttgtgctata
      301 tttaattaat tcgaccttta atttccatat ccttcctatg ataacaaaac tcttttattt
      361 ttttaatgat tcattatcat ttaaaacttc ttttatatca agtacttctt tgttatcatc
      421 actcataact tcctttattc ctttgaatgt tcctaggaaa ttaactgctt ctgaaggtaa
      481 aaccagtttt gttgacttac cttcagccat tttttcaaga gcttccatag attttaatgc
      541 tagaatatta ttgtctatat cagcctcttt cattgctgaa aaaactaatt ttaaaccttc
      601 tgctgttgcc atttgagttc tttttatcat ttcagcttca ccttgtgcct tagcaatagc
      661 tgtctgtctt atagcttcag cttcaccttc tgccactaat atagcagatt ctttttcacc
      721 ttctgctaca cgtaccatag cttctttttt ggcttctgct gttaatattg cagattgttt
      781 ttcaccttct gcttgaagta ttgcagctga cttattacct tctgcttgaa gtattgcctc
      841 tcttctttct ctttctgctc tcatttgttt ttccattgca acttgaatat cctgaggagg
      901 cattatattt tttaactcta ctctatttac ttttataccc catttatctg ttgcttcatc
      961 aaggatagtt ctcattttta catttattat atctcttgat gttaatgttt catctaaatc
     1021 aagttcacca attatatttc ttagtgttgt agctgttaaa ttttcaatag cagctattgg
     1081 attagctatc tcaaacacat atctaactgg gtctgtaact ttataatata caactgtatc
     1141 aatctgcata gttacattat ctttagttat aactggttga ggtggaaaat ctattacaat
     1201 ttctctaagg tcaattacat atgccatttt atctaaaaat ggtattaaga aatgtacacc
     1261 tgtttcagct actttttgaa acttaccaag tctcattatt atacctactt tagattgttt
     1321 tataactctt atacaagtta aacttattgc tacgactact actattaata caatacttaa
     1381 aacaatttta gtacccatac tataaatcct cctttattct attggtttgt cacattaact
     1441 gtggcgtcta cttttttaac aactaatttt accccttcaa tttttaatac ttctactgta
     1501 gaaccttttt ctatcttttc accatctata gaaatagccg tccatgtttc atgttcaact
     1561 acaactagac ctgtgttatt tggagaaatc tcttctgtaa caataccttt tttagacatc
     1621 attgcttgta aattagtgtt agatttatag cctttatctt tttttactat ttttttagta
     1681 gctacgacta acattgctat agaaattact gcaaatatta aaatttgtaa gaaaatactc
     1741 tctataaagc tacttaaaaa tataagtatt acagctccta cactaaacca tatcaatgtt
     1801 aagcttggtg ttaacatttc tgctattcca aataagactg ctactatcaa ccatattaac
     1861 ttcatactat ctaccctctt ttcatatgaa ttataaaacc ctatataaat tatatgttta
     1921 tacaatgttt ttgaatataa atttaaatta caaaacaata aaataaatta attaattaat
     1981 taatagtatt atatcaacat actttgttaa atttgttaca aagtagtatc aaatatcacc
     2041 aattatatat ccaacaactc tttcattgtt aatgaaatgt tacttattaa atccgtagca
     2101 tttaccgtat acattgcttt gctcagttta tctcctatat agccatgtat atatgctcca
     2161 ctaactgtag cttccaatat atccatacct tgacctataa atgaagtaat cattccaagc
     2221 aaacaatcac ccattccacc agttgccata cagctatttc ctgtaggatt tatatatgtt
     2281 tttttaccat ctgttatgac agtttgataa ccttttaaaa gcaccaccag attatatttt
     2341 tgagcaaatt cttttgcaac atctactcta tgttctctta tatacccaat tgaatctcct
     2401 gtcaacctgg ccatttctcc caaatgaggt gtaattacaa atctattttt ccattctaaa
     2461 aacttataac atctgtcctt cataacgttc aatccatctg catctaatac tattgggcaa
     2521 ttagaatttt ctactatctt aagtaattta tcaaatgttt gactattatc tcccatacct
     2581 ggaccaaaac caattgcatc actagaatta agtaatttat ttaatctttc ttcttcaaaa
     2641 tttaaagtca ttgcttctgt aagtctaata gatacctttt cttgcacatc ttcactacta
     2701 attaatgtta caagtccact cccactctta acagcagatt cagttgctat gaaacttgca
     2761 ccataaaatc cttttgaacc tgcaactata gatacttttc caaaatcact tttaaaacca
     2821 tgcttatctc ttcttctaat attatttttt acaaaagtct tatcagttat gaactcttca
     2881 tcatggtatt ttcttgtaat aaaatctgga acacctatct tttctacaac tacatcacct
     2941 ataagtgcgc tagtgtcata gtttagaaaa cctcttttat aaaactcaaa gctaatcgtt
     3001 ttgtttgctc taatacaagt tcctaataca tttccattat cgctatctat acctgaagga
     3061 atatctatag aatacgtatt tttgctatta tcgtttacta tgtcaataac ttctttaaaa
     3121 ataccagtta tatcacgttt taatccagtc ccaaatatag catctactac aacatcactt
     3181 ttagatactc tatctttaaa aattgttaaa tttttatttt ttataatatt ttgtttctca
     3241 actttaataa ttttatctac ttcattttcc tctccataat ttttttcact taaatcattt
     3301 ttattaatat ttataatatt aattcccata tttaaaagta cattgtaatt tattttagag
     3361 cattcactta gtttttcaag attacctact aaaaatacgt ttacttcttt tccatatgta
     3421 tttagatgtc ttgctattcc aagaccatct cctccattat ttccaacacc acatacaact
     3481 gtataactat tatacatgtc tatatccata tttttcattg cagatataac cgcattttcc
     3541 atcaatacaa tcattggaat ccctacttct tctacacatg cagtatcaac atttctgctt
     3601 aatttagatg tacctattag cataaattat cactcctata aagttaaaga cttcttaaat
     3661 acttaccaaa aatatctatt gaaatctttt taatcccata aatatcataa ataaaatcac
     3721 taaaactaag agttttgaaa taatttaaaa taacaaaaaa ttttgaatta aaacaattat
     3781 ttaatttatt ataccatata atttaagtta ttatgttgat ttaaaaccta tttacactaa
     3841 ttatctaaat atctctttat ttttataatc ttttatgact tatttatatt tttcattttt
     3901 ataaaaaaac aataattaag aatataacta tattctacat gtaaaaattt ttttatttaa
     3961 actcaatttt ctgataattt gataattttt caaaatttat agttgacttt tattttttac
     4021 tgtattaaac taattactat acaaaacaga aaacaaaatt ttcaaaatta ttaaattaaa
     4081 aggagaggta aatatgaaga ctttattaaa caaacaagta cgatttttta gtagccaatt
     4141 tagttagggt ttgtacctaa gttaagacaa attgtcataa catagataca agccccttag
     4201 gattatgatt tttaaggatt gtatctatgt tggctatagt aattgttgtt aaagttttta
     4261 ttttatcatc ataatataga gccacatgga ttatactgtg tggcttattc gaatttttgc
     4321 catacagtta tatatactgt gtggtttttt tatatcaaaa tcatttttta aaaccaaatt
     4381 ttaaaaacca tttaaaatat tttcaaaggg gtgttttatt tatgtcaggt attatatctg
     4441 taatgacgca aagtttaatt ttatcgatta tggcactggg ggtttatata acttacaaaa
     4501 tcttagattt tccagatatg tctgctgatg gtagctatac aatgggtgct tctattgtag
     4561 cattttctct tactaatggt atttctcctg tagtagcaac tttaatggct atcttatgtg
     4621 gttgtactgc tggtcttgtt acagggattc ttcacattaa gtttaagata tctaatttac
     4681 tttctggtat tttagttatg ggaatgctat actctatcaa tttaagaata atgggaaaat
     4741 caaatattcc tctatttagc tttaaacact tattcaatgg ggaaatatct cctatagttt
     4801 tagccttagc ttttgtattc atctgtaaag tccttttaga tttattccta aaaacaggtc
     4861 ttggatacac tttaaaaggt gttggtgata actctcaaat gattaaatct ctaggtataa
     4921 atataggttc tataaaaata ctaggactta tgatttcaaa tggacttata gctttatctg
     4981 gtagtcttat ggctcagttc ttgggattct cagatgtaaa tatgggtata ggaactttag
     5041 ttcttggaat tgcctctatc ataattggta ttacactatt taagaaattt acttttatca
     5101 aagatactac tgcaataatt gttggctctt ttatatacca attcactata tactttgcaa
     5161 tgagtttagg aatgttatca actgacttaa aactaataac tgccatagtt ataatagctt
     5221 tcctagctac tggtaactta aatatttcac taaaaaaaaa caaatgcaaa gctagtacca
     5281 aaaataaatc agaaaaaaga ggtgttgtag atgttacaaa ttaaaaatct ttcaaagagt
     5341 ttccctaatc catatggtga acctaatact atctttgaaa atttatcaat cgatatagaa
     5401 gatggtgaat ttgtaagtat cataggtagt aatggaactg gtaaatctac tttattaaat
     5461 ataatatctg ggcttataaa agaatcttct ggtcaaatta ctttagatag tactactata
     5521 acaaatttag ctgagtataa aagaactcaa atagtaagta gagtttttca agacccaagc
     5581 cttggaactt gtccttctat gacggttaga gaaaatttat ctctagcact taataaaggg
     5641 aaattattga acttaaaaaa atgtcttcgt cataaaacga atgacttgga acacttactt
     5701 gaaggaattt ctttggattt aaaaaaatat ttagatatta aagtacaata tctttcaggg
     5761 ggtcaaagac aatcactatc actaattatg tctagcttag caagtcctaa ggtcttatta
     5821 ctagacgaac atacagcagc acttgaccca aaaacatcaa atgaagtaat agagttaaca
     5881 gataaaatcg taagagagaa aaatataact acacttatgg ttactcacaa cttgaaacac
     5941 gctcttcaat atggagatag gttgataatg cttcataagg gtgaagttgt attagatgta
     6001 aaagataaag aaaaaaaaga tttaacagtt gaagaaatct tagaaaaatt tgaatatgca
     6061 gtataagaaa ttaaaatctt agttttaatc agaaatattt ataatctatc atatgaatat
     6121 atgaacaaat ataattatta aattttaagg gaggaaaata aaatgataaa aagtaaaaaa
     6181 atattaagtt taattatagc aggagtactt ggtgtatcaa tgcttactgg atgttctcaa
     6241 aatgatggct ccaatgcttc aaatgaaaat aaagaaacag atagcaaaaa acaaaaaaat
     6301 ataggtatta ctcaattagt ggaacatcca tctctggata aagcaaagaa aggattcatc
     6361 aaagcacttg aagataaagg ctataaagat ggagataata taaaaataga tttccaaaat
     6421 gcacaaaatg atatgcctac tacacaaagt attgctagta agtttgtatc cgacaaaaaa
     6481 gatttgatat atgctatatc tactccatct gcacaagcag cttataatgc tactaaagat
     6541 attccaataa taatgactgc tgttacagac cctgtagaag ctggacttgt taaatctctt
     6601 gaaaaaccag gtggaaatgt ttctggtaca tctgattatc tttcaattga taaaacatta
     6661 gaattggtta aaacattgac tccaaaagca aagaaaatag gggttatata caatactagt
     6721 gaagttaatt caaaaatcca agttgattct ctacatgatt atgctaagaa aaataattat
     6781 gaagtagttg aaaaaggaat cagctcttca agtgaagtta accaagctat ttctagttta
     6841 gttggtaaaa tagatgtttt atatgtccct actgacaatt taatagtttc ttctatgcca
     6901 atagtttcta aagttgctaa tgaaaacaag attcctataa tagcctctga agaaggttct
     6961 gtatcttctg gtgctttagc ttgttgtgga atagattatg aaaaactagg ttataaggct
     7021 ggagaacttg ctattgaagt attagaagga aaatctgttg gcgatatacc agttactaca
     7081 ttagatgaaa ctgaaataat aattaacgaa gatacactaa aagcacttga catgcaaaag
     7141 ttatcagcag ataatataaa gtatataaag tcagatgaaa atgcaaaatc tacaaaataa
     7201 aacttattaa tttcaaaaaa taggtaatat gaagtaggta atatgaaaac tttatataat
     7261 aagtactctt atccacccta accctttgaa aattgtgctt attgtagcaa tttgaatatt
     7321 gcatataaag ttattcattt tccataaaag tcgtctatat tgacgactga ttatgaaagt
     7381 tatataactt tctaatcact acttgagctg tccaaaagaa ttttaatatt ctccagacag
     7441 ctttttttta tgatatttga ttgatataca tgtctagtta ttccatattt agtaaatatt
     7501 ttgataaaat ttccacattc acttataact taggataacg tttttttcaa acaatacatt
     7561 aatttaaaag tattctgagt atacattatt tagtatttta attaaattta gcagttgact
     7621 tttattattg tataatttat aatttataac aagtcgagaa tacatataat tttctgacta
     7681 attaaaatat taaaagggag agataattat gaatacttta ttaaacaata gaaaatatta
     7741 ttattattat agccactatt tttagggttt gtacctacgt tttaacatag atacagaccc
     7801 cttaagacta ctaaaatttt gggattgtat ctatgttggc tatattgttt ataaagtttt
     7861 catttaacta tataagagcc acatagatta aactatgtgg cttattcgtg tttttaccac
     7921 atagttttgt acactatgtg gtttttttat acacaaaatt agcaaataat taaaattata
     7981 aaaatatttt caaaggagtg ttttatttat gtcaggtatt atatctgtaa tgacgcaaag
     8041 tttaatttta tcgattatgg cactgggggt ttatataact tacaaaatct tagattttcc
     8101 agatatgtct gctgatggta gctacacaat gggtgcttct attgtagcat tttctcttac
     8161 taatggtatt tctcctgtag tagcaacttt aatggctatc ttatgtggtt gtactgctgg
     8221 tcttgttaca gggattcttc acattaagtt taagatatct aacttacttt ctggtatttt
     8281 agttatggga atgctatact ctatcaattt aagaataatg ggaaaatcaa atattcctct
     8341 atttagcttt aaacacttat tcaatgggga aatatctcct atagttttag ccttagcttt
     8401 tgtattcatc tgtaaagtcc ttttagattt attcctaaaa acaggtcttg gatacacttt
     8461 aaaaggtgtt ggtgataact ctcaaatgat taaatcccta ggtataaata tcggttctat
     8521 aaaaatacta ggacttatga tttcaaacgg acttatagct ttatctggta gtcttatggc
     8581 tcagttcttg ggattctcag atgtaaatat gggtatagga actttagttc ttggaattgc
     8641 ctctatcata attggtatta cactatttaa gaaatttact tttatcaaag atactactgc
     8701 aataattgtt ggctctttta tataccaatt cactatatac tttgcaatga gtttaggaat
     8761 gttatcaact gacttaaaac taataactgc catagttata atatctttcc tagctactgg
     8821 taacttaaat atttcactaa aaaaaaacaa atgcaaagct agtaccaaaa ataaatcaga
     8881 aaaaagaggt gttgtagatg ttacaaatta aaaatctttc aaagagcttc cctaatccat
     8941 atggtgaacc taatactatc tttgaaaatt tatcaatcga tatagaagat ggtgaatttg
     9001 taagtatcat aggtagtaat ggaactggta aatctacttt attaaatata atatccgggc
     9061 ttataaaaga atcttctggt caagtattat taaataaaca taacttgtct aatttagctg
     9121 aacacagaag aactcaaata gtaagtagag tttttcaaga cccaagtctt ggaacttgcc
     9181 cttctatgac tgttagagaa aacttgtctt tagctcttaa caaaggaaaa ctattaaatc
     9241 taagaaaatg tcttcgttac aaaagagatt tcttagaaaa tttattggaa ggtgtatctc
     9301 ttgatttaaa aaaatacctt gatgttcaag taaaattttt atcaggaggt caaagacaat
     9361 cattatcact aattatgtcg tgcttaacaa atccatcagt tttattactt gatgaacata
     9421 cagcagcact tgacccaaaa acatcaaatg aagtaattga attgactaat aagattgtaa
     9481 gggaaaaaaa tataactaca cttatggtta ctcacaactt aaaacacgct cttcattatg
     9541 gtgatagatt gataatgctt cataagggtg aagttgtatt agatgtaaaa ggtaaagaaa
     9601 aagaacaatt aacagttgaa gaaatcttag aaaaatttga atatgcagtt taaaataata
     9661 tatctattgt attaaactcg gctttaaaat aaagttaaaa ttacaataat tatggttact
     9721 ttgtaataat tcatatgaat atatgaacat atataataat aaatttttga gggggatata
     9781 aaaatgatta ataaaaaaag attggcaagt ttgattttag ctggtgctct tagtatatct
     9841 atgcttacag ggtgttcaca aggaggagac tctggtaatt caaaacaaga aagtaattct
     9901 aaaggtaaag aagttaaaaa aattggtata actcaactgg ttgaacatcc agcattagat
     9961 gccactagga caggttttgt aaaagcatta gaaaagaacg gatttaaaga tggagaaaat
    10021 attgatatag acttccaaaa tgctcaaaat gacatgccta ctacacaaag tattgcgagt
    10081 aaatttgcat ctgataagaa ggacttaata tttgctatat ctactccatc agctcaggca
    10141 gcatttaatg ctactaaaga tatacctata cttattactg ctgtgagtga ccctgttgct
    10201 gctggattag ttaaaactct tgaaaagcca ggcacaaatg tatctggaac atcagatttt
    10261 gtttctgtag acaaaggttt agaacttctt aaaatatttg ctcctaaggc aaaaactata
    10321 ggagttatgt acaatactag tgaagtaaat tccaaagtcc aagttgatgc tttaaaagaa
    10381 tatgcatcta aaaatggatt taaagttgtt gaaaaaggta taactacttc aaatgaagtt
    10441 aaccaaggta tttctagttt agttggcaaa atagacgtat tatatgttcc tacagataac
    10501 ttagtggctt cttctatgcc tatagtctct aaaatagcta ctgagaataa aatacctgtt
    10561 atagcagctg aatctgggcc agttgaaaaa ggtgctcttg cttgtcaagg tatcaactac
    10621 gaaaaactag gttacaaaac aggtgaaatg gcagttaaaa ttttaaatgg tgaatcagta
    10681 tctgatatgc ctgtggctac atcagatgat acagatatca ttgttaatga agatatatta
    10741 aaagctttag gtatggaaaa accttctaat gaaaatattt cttatgtaaa gactaaacaa
    10801 gaatagaaag atattttcta tatacgatta atatgcctgt ttctataaat taatttatag
    10861 aaacaggcat atatttttat tttaatgtat tatctattta aagattatat gtaaatgctc
    10921 ttaatttgtt tgtataaatt ttacttgtat aaactttata caatcatatt tattcttcta
    10981 ttttctttat tactctacat ggatttccaa cagctacagt atttggtggt atatcttttg
    11041 tgactacact tcctgcacct attactacat tatcacctat agtaattcct ggtgttatga
    11101 ttactccccc acctatccat acattatcac ctatttttac aggagaacca tactctatac
    11161 ctgaatttct aagttgtgca tcaattggat gataggctgt atagatttga acgtttggag
    11221 ctaacattac attgtcacct atttcaattt tacatacatc taaaaaaata caatcataat
    11281 ttgcaaagaa attttcgcct acatgtatgt tatatccata atcacaccta atattttgtt
    11341 ctacatttat ttgcttgcca actgaaccaa atagttgtct taaaatatct tctctttttt
    11401 catattcatc ctctaaagta ttattaaaca atctagttaa ttttttacaa tactctcttt
    11461 cttttactaa caattcatca tttgcatagt atcctttccc agacaacatt ttttcttttt
    11521 cagtcatata gtttactcct ttttgttata attgtatcta aagcaaaata aatattcctg
    11581 tggaaaatct aaatatattc tgtcaccttt cttaaatctc attttacttt tttccaattc
    11641 tatttgaata ggtacacatt cgttagataa atcagttttt ctaacatata tagtatatgt
    11701 aaaaggattt tctacaatgt taatcaattc gaaacataac ttttcattta aatcttcatt
    11761 agaatccaag accttaatat gatgctccct gattcccaca tattctatat tatcacctat
    11821 ttctctattt aatgtcaact cgcatcccca gtctgtagca taaatagtat ttttatccag
    11881 tctatttaat ttggatatat ttttacaccc tgttatctta gcttctataa ggtactttgg
    11941 agattcaaag agctcttttt taggtctctt tggaagacct tctcctttgt tgtacactat
    12001 aatatcatca caaactcggt aagcttcttc aatatcatga gtaacaaata gtatatctcc
    12061 cttgtaatct tttaacatat tcataagttc tttttccata ttgcttctta aatgatggtc
    12121 caatgctgag aaaggttcat ctaaaagtaa tatatctgga gatgttgcca atgctctagc
    12181 tagtgctacc ctttgttgtt gaccaccaga taattgccaa gggtatctcc cctcaaaccc
    12241 atttaattta agtatatcta agtaccttgc tactatttcc tttttttcac tcttacttag
    12301 ttttaaaagc ccaagttcta tattttgact tacagtcata tgtggaaaca aagcatagtt
    12361 ttgaaataaa aatcctacct ttctatcttg tgttgataaa tttatcttct tttcagaatc
    12421 aaatagaact ctatcattta atacaatttt acctcttgtt ggtttctcaa gccctgctat
    12481 acattttaat gtcatacttt ttccagaacc agattctccc aaaaacccca gagtaccttt
    12541 ttcttgttta atttctacct ttagtttaaa agaggataaa tctttttcaa tatccacgta
    12601 taagctcaac tatccacacc tctttcctat aattttctgc tgaaattccg accaataatt
    12661 tagtaataaa atcattgcta tagatattgc tacaataatc ataacccaca tcatagcttt
    12721 attcatatct ccgccttcaa cagcaaaaaa tatagctatt ggcatagttt gagtttttcc
    12781 aggtatattt ccagctatca taagtgtagc accaaattct ccaagagctc tggcaaacga
    12841 cagcaccaat ccaccaatta ttccaggcca tgctaatgga actgcaatct taaaaaatac
    12901 tttccattca ttaagaccta atgttctagc agctgacaac atattattat caatctgttc
    12961 aaaagctgac cttgaagttc tatacatcat aggaaaagac accactactg ctgaaattac
    13021 agttgctgtc caactaaata ttaaagtcct atcgaaattt aataaaaact ttcctataaa
    13081 tccattcttc ccacatagta ataataaaaa gaaacctaca actgttggtg gcaaaattag
    13141 tggaagtgta aatagtccat ctataagacc cttccactta cctctatagt tagccataat
    13201 atatgacaca aatattccta ttacaaaagt tattattgtt gacaaaatag atgtcttaag
    13261 tgatatccat aagggtgacc aatctgttcc catctttccc tccttaattt taaatggaaa
    13321 tagtgaaact aataactcta ttaatttcac tatttccatt ttattataat acacaattat
    13381 tttcaatttt catttattta tatataattt atacttaatt acacataatt tatttctaag
    13441 tttattctac ttttttatat ccaaattctt caaaaatctt ttgtcctgac tcacttaata
    13501 aaaattcttc aaatttctta gcagcatcta cgtttttact agctttaatt actgaaactg
    13561 gatatgtaat aggcgaatga gttttttcgt ctgttttttc aactactttt atcttatcat
    13621 tattgacagt atcactgaag taaacgaatc caacatcagc atttcctgat tgcacccatg
    13681 ctaaaacttc ttttacatct tttgcaaata ctagcttatc ttttaactta tcttttaaat
    13741 ttaaattagt taacacctca tctgcatact taccagctgg aacactttca gcttcaccaa
    13801 cagcaatttt cttcacttta tctgtagtca aatcttccat acctgataca ctactgtcag
    13861 cagaagaaat aagaactaaa tcatttttta ctaaatcttt catagtatca gaaactaata
    13921 acttctcttc atccaaagct ttcatttgtt tttgacctgc tgaaataaat aaatcacaag
    13981 gtgctccttg ttctatttgt tgttgtaatg agcctgatgc tccatagtta actgtaagtt
    14041 ttacatttga atcaactttt ttatattctt cttcaatctt tgccattgct tcttttaaac
    14101 ttgcagcagc cgatatattt aactctactg aatcactact tttagttgtt ttttcttgtt
    14161 ttccatcatc ttttttgtct tcattactat tgcacccaac tgtccccaaa gttaaacatg
    14221 caactaatcc taatattccc aatatttttt tcataacaat ctcccttttt gtaaatttga
    14281 tacacatttt aacatgtttt attatgtttt atcatgtttt gttatatata gtttaattat
    14341 atatacatga taataaattt tcaagtaatt tatttacact acttttaaat attttgctac
    14401 attttccttt ttttaatgtt aaaataacct tatatggagg tggattatgg actcattatc
    14461 atctttgaca cctgtcgagg tagctgaatt attaaagata acaaaaaata ctgtatatga
    14521 attaatcaaa agaggtgaac ttccttctta taaagtaggg aaaaaaataa gagttgatac
    14581 taaagatgtt gaagaatata tcaacagcca aaaaactggt aaagtaaagg atacacattt
    14641 caacaataaa aatatagata taaataataa tttcaaaatt attatttctg gtcaagatgt
    14701 aatattagac attttagcta ggtctgttga aaaaaaattg gatggaataa gtacatttcg
    14761 ctcttatata ggtagttata atgctttgta tgagttatat aatggcagag tttctatagc
    14821 atcatcccat ctatgggatt tcgaaacgga tgaatataat agcacttttg ttaaaaagct
    14881 attgccagga ataccatgtg tacttataaa tctagcttat agaatgcaag gtttctatgt
    14941 tgctaaagga aatcctaaag agataacaac ctgggaggat ttaacaaaac caagtataac
    15001 cattgtaaat agggaaaaag gttctggaac tagggtttta ctagatggta aacttagact
    15061 tctaaacttt aatggtaaac atataaaagg ttatgataat gaagaattat cacatcttgg
    15121 agttgcaagt actgtttctc gtggaatagc agatgttggt ttgggaaatg aaaaagctgc
    15181 tttacaagta aataatatcg actttattcc tcttcacaaa gagcgctatg atttagttat
    15241 taaaaaagaa gacttacaaa atccagttta ccaaactata attaacataa taaactctcc
    15301 tgagtttaaa gctgaacttc aaggtcttgg cggatatgat ttaactgata ctggaaaaac
    15361 tatagcaaaa gtttaagatt aaaatcgcaa tctattttat aagatttata atttttcaca
    15421 aaatttataa cttaaacacg aaataaattg cgattttagt gtctcaaaaa atttatgtct
    15481 ttcattttat catccaatac aaaatataat ataattaatt gtgcaatcat attatattaa
    15541 tatatattta cataatagta tttttcttta atgtagatta acatatgata tgttttaaac
    15601 atcaatcccc ttgctttctt atatatattt ggcaacacat atgagtttaa taaattatat
    15661 acaatgttgc tttcttcttg tattttttca accaacaagt tatttataaa attacctttc
    15721 tcattttcaa taatctcact ccaatttatc ttaactttta atatatatct tcccactagg
    15781 tatacacact ctacaataaa taataaaaat acaatgcagt cagtacctgt tgtcttatat
    15841 aaattacccg atactaatgg ctttgcgaag aaattataaa aattcaaagt atcacccgta
    15901 taatcaaaaa gtattaatag cactcctaga actctcaata ctttaatatt caacatgttt
    15961 ttatctttat tatttttgtt tttcatatat actacctctc ttttctttag atttgattgt
    16021 aatctaatac taactctttt atttgaggta taaatgaatt taattggtag ttattttcat
    16081 ttttactaga aattaattca cattactaaa caaaacttat atttaaacat aaaaatagcc
    16141 tatctatctt ttaataaata caaaaataaa taagctacta atattcaatt aacttttatc
    16201 acttaaaaca ttactatcta taaatttaaa tattttattg aagtatactg tactatcatg
    16261 ttcaaatcca tcaacatgac caataccttc tataagccat aggtcttttt tatcatgttt
    16321 aactaaatca tacattttct tgctattttg ataattacaa acagtatctt ttgttccatg
    16381 tataaacagt atgggtacat tagatttctc aactgactca tatggtttta catcactgta
    16441 ccaaaatcca gatttaaact tattatataa atctccacaa gtcaccacat aattgattaa
    16501 tatatctggt attcgttttt ctagtactcc cattctaatt gcatctttca tttcagaata
    16561 aggagaatcc agtatataaa aatcgacctt atcatctttt gaatttatct ctgaatgcat
    16621 agcagctgtc cctgccccca tggaaaatcc atgcacacct aatctccctt caggaaattt
    16681 attttttaca aatttaacta gactatctaa atcatacctt tcataaagac caaatgtgta
    16741 attatctcca ccactattac cagtatttct ttgattataa actaatacat tataaccttt
    16801 atctaaatat ctatatgcta cctttaacat ttcatagtaa ctacttccaa ttccatgaac
    16861 aagtatcata gtatctcttg tctttatatt tgaagttata aaaagacttt caagcttgta
    16921 attattagaa ctttgtatca ttaattcaga tgtcttgtag ttttttaatt tctccagtgg
    16981 tttatctttt ctctcagaaa atatttttac tatatcttcg ttttttatta actgctctaa
    17041 accaactgaa ctattataca ctaattttcc aaatatataa gatacaatta ataggattaa
    17101 tagaaacaca attgatataa ttataaattt atttcttaaa ctaatacaat ttttaaaact
    17161 atttttcata tttatttacc atacaatttt cctatattat attttctaag taatagcata
    17221 attgattata ctattcttat aatttctatt atacctactt atttattaaa aatacaaatt
    17281 atattttatt aatttttact acttgtaaat tattatctta tacaatgaat ttgtattata
    17341 taataagtat ttttaggatt ctgttacata atattattta aatattcttc tatatttctc
    17401 ttcttcttct tcagtaaaca cattaaatac aacttttaaa tttttttcag gattttcttt
    17461 tagccatagt ctaactctac ttacagcaag attagctgcc tctttttttg gataaccaaa
    17521 tacacctgta gaaattccac aaaaaacaat attttttatt tcatcaattt cttttattgt
    17581 atttaaacat gatttataac aatgaagcag ttgcttttct tgctctttac ttggctgacc
    17641 accagataca ataggtccaa cagtatgtac tacaaatttt gcaggtaaac aataacctct
    17701 agttatctta gcatctccag tatattctaa atgcccttgt ttttttatta ttttgtcaca
    17761 atcttctcta agtctaggac ctgcgcatga atgtatctca ttatccacgc atagatgtaa
    17821 tggttgtaaa caccctaata acttgttatt tgcagcattt actattgcat ctgctcttaa
    17881 attcgttata ttacctctcc atatggcaat cccttcctct acttcttcta tatcatttac
    17941 atctactaac tctctttctt cacattcaat caacaataaa ttatgtaaca tattaagtat
    18001 ctctggagca atttcttttg gtggatatac attcaaaagt cctctaagta tatctctagg
    18061 cttaatttca tcatttgata aattgtatat tttagaagga acttcttttg aaaaatatgc
    18121 aattaaagtg tttatatttt ttcttctttg ttcgtcagtt agaggcttga tagttttatc
    18181 aaaatcctca aataaattta catcatcagc ataatctctc cacttcatag ccatctctcc
    18241 attcttgtat tttagactta aaaataatta tgtatttatg tacatattta tttatttcta
    18301 taaacaccta cataaatcct gttaaaagtg taaatttttt attatacaac ttctctggtt
    18361 atttctattg attgatagta aattattgta cctaaattta atccaactaa caagtaacta
    18421 aacctacttt cctaactgca aaatacacta tgtttgccac ttgtatctca tttgtagata
    18481 aataaagtcc ctacaaatac attaactagg ctatgtacta aactgtagga actttaaaaa
    18541 tatattattc ttaattaagt tttggccaat aatttttatt tgcttctatt aaatcatcta
    18601 gtaattcttt tgcaactgtt gcactaggaa ctgtcttaga tagcataagt gcttgccaca
    18661 atttattata agacttctca atccaagcat caactactaa tttttcaact gctaattgtt
    18721 gttctattaa acctttttgg aatgttggta ttttccctat tgataatggt tcatacccgt
    18781 cttttccaac tatacatgga atttcaacca tagcatcatc ttgtatattt tctatagctc
    18841 cattattttg aactatcaat aacatacgct cctgtgtatt aaaagctaga gctgtagcta
    18901 aatccactat aaactctgca tgtattccta tcttaagccc actgccctta gaatgtcctt
    18961 gcttttctat caatgcacat gaaccaaaaa cttctttttc tcttccatca ataacttcat
    19021 tggcacgagt ataatttaca tcagaatgat ttacaacata atctggaaat agatagtact
    19081 ttaagtaact acttggtatt gtagttaaat ctgtttttac tatttcttta gtaaataaat
    19141 tagtttcaaa ccaactatct ttcttgtcat ttttcattcc ttcttcacca tttataaaac
    19201 catattcttt tatatgttct actaattttg gtaaaagttc atttcctttt ttatctttaa
    19261 ttgaagtata ccaaccaaag tgatttaatc caaagtatct tatatccata tgtttacgag
    19321 atttgagtcc tgcaatcctt gctatattat gttccatacc tattggcata tcacaaatat
    19381 ttattaccct agaattaggt ctcaaccttc taacagcttc cgctattatt gatgctggat
    19441 tagaataatt taacatccaa caatttggag aatacttttc catataatct atgttttcaa
    19501 gaacaccttc tatagacctc attccataag ctattccacc tggtccacaa gtttcttgac
    19561 caactacccc atgttttaga ggtatctttt catctagttc tctcatttca agttttccaa
    19621 ctcttatatg agctaaacaa aaatctacat ctgtataagc ctctttaggg catgttgttg
    19681 ctaaatactc tatattaggg tccttttcct ttattagtat ttcacaagct ttagctacct
    19741 tattttgtct ttcttcatca ttatcatata atttgattgc tcttaatggt aacctatcta
    19801 agttatctag caacattaat atgatttctg gggtatatgt acttcctcct ccagctatta
    19861 ctactgaaaa tttttccata ataatatctc cttttctatt taaaaattta ctgtatttat
    19921 aaataaattt ataaatacta gtactttaaa gtaaaaggga gttcatttat taaatctatt
    19981 gatttaataa actatagcca aacttcaagc actatttaca agaaatttaa ttcttattaa
    20041 ttcttgggtc catcatctca aatatatcta caagttcaga tactaaagaa tgagcaaata
    20101 atgcatttga ataatggtct tcagagtgca caactaaaaa atcagtccca ctatcttcac
    20161 tattcatagc atttgatagt aattctaaat gatgctttga tgctgtttgt attttctctg
    20221 aggctgaatt taaaaggtgt tttgctttat tgtagtcacc tttttttatt tccttaagag
    20281 acatcattac atcactttta gcatctcctg cttctgatat tatactaaat actttttctt
    20341 ccatttcagg taccatatcc ttctccttct aatgacttgt taaaaatcaa agctatcatc
    20401 atctaatgtt gtagctaatt ctgcattttt atttaattct tccttctcca ttatcttaaa
    20461 gaatggataa tatatcaagg tcataagtat tatacttgca aatactaata cgattgcctt
    20521 ccaatctaat gtcatcaaaa atgctgcaac ccctggaggt aaaaagcctg gtggttctgc
    20581 aataggtaat cctactaatc ctacttttaa tgccataaaa ttaagtgctc caaccaatac
    20641 aggtccaaat acaaatggta caaacatata tgggttcata actattggtg ttccaaatat
    20701 taccggctca tttattccaa atagtgatgg taaaatcaca acttttccca tactattaaa
    20761 actcttacac ttacttcttg acataaggta cactaatccc aaagttattc ctgaaccagt
    20821 tacttgcaag aaaccatagt aaaatcctat tgtaaacaca tattttgggt ctcctcctgc
    20881 tgctatcagt gttgcatttt ctgccatata tgtagctgct attggcatcc atatacttga
    20941 agttattgct gctccatgaa gcccaaagaa ccataataat tgagttataa atagtattat
    21001 agttactgca aaaacattat ctacactgct tatagctggt gctaagaaat tcattataat
    21061 agctggtagt ggttgacctg agacattttt agttattgct gctattgctg taaataacat
    21121 tatacatact atcattggag ttaaatttct aaaactttta tttactacac taggtacttc
    21181 ttttggaaat ctaattacga gatttttatc attcataaac ttagtaatat caactactaa
    21241 aagtgctact aatatactta caaataaacc ttgtgcatct aaataacttg tatctaatac
    21301 accatctact acttgtccac atacaacaag ttgtgcaaca actgctgtca tgcctatttc
    21361 tacatgatta agattatatt ttttagctag tgcctgagct ataaaaaatg ctgaatatat
    21421 agataataaa ctcatagtaa atttattagg gataagtaat gtatccatat tttcagataa
    21481 taatgttttt gcacttcctt caggtaacat attgtttaat gccataaata acatacttaa
    21541 agaaccaaca attattattg gggtaatgct tatcatacct tcttttatag cttgaagatg
    21601 cctttgtttt tcaatctttt gtgctattgg aagaagaaat cttcttaaat tattttgaag
    21661 tgcttccatt tttattcccc ccaattatct atttttatat aattcgattg ccgacttcat
    21721 aacagaagga gcatccatac gaccataatg cttagtatct attaaaccaa ctgctatttt
    21781 gtaattctta caagcttcaa ctacatcatc ttccttaaac ctaatttgtg gtgctacaag
    21841 tactacatct gtatcattag cttcaatgta tgattttaaa ttttcaaatg atgttgcctc
    21901 tatatttata gttttagttt ttaacttttc atgctcacta caaaaacttt tcatcttttc
    21961 cacaagtaca cctgttgaag ctccatttgc acatactaat aaaatattca taattaccct
    22021 cctacaatat ctaacctctt ttattttcta attttttatc agccaattct tactctaatt
    22081 cctatcagtt tttactttaa ttcttattat tttattttaa ttcttattaa tatttactct
    22141 aattcttagt actgccaatg attaaacttg aaagccgtat ctataacttc ttcttgctta
    22201 tatttttcta atatttttaa gtatctttct ttataatcat tatctacttc tttttctggt
    22261 attactatac tagcttcatt taaaaagtgg aatgaatccc ttcccatttc taatcctcta
    22321 tatgtatgct tgtcaagtgc cacgtccata acttctggaa ctttacccat tgcaaatcct
    22381 tttataatta tattttttaa taaatcactt gatctatctt tctcacatgc acaaagatat
    22441 cttattgcat gtatgaaaaa taaaggtctg tctccatctg catatgaata ttcctttctt
    22501 acttgattta aattatttat gattattaca gctgatggat cccccattcc tatatcttca
    22561 actgatattg taagtatcct tctccatagc ttatcttcta attctggtga tgatatatat
    22621 agttcataag caaattcaca agcttcttcc accatatttc ttcttatagc tttttgaaat
    22681 gacgatatta tttcgtctgc actaaatccg tttcttgtag tcattcttgc ccatgggtca
    22741 tttgcctttt tatctcttaa tattttatct tgcatattat ttactccttt ttatttaaat
    22801 tttaattatt tatattactc atttaataat ataagcaagt attatgccag tttttttaga
    22861 cactttaaaa cactgttatt tcaatcattt ttatcatcaa aacttagata ctttgtctaa
    22921 gtatatttat atgtgtctaa tattaatatt attttagact aaaaaaaaat taccaaataa
    22981 gtttttatac tcattggtaa tctttttcga ttatttctgc atattctaat attaataata
    23041 tttgatagca ctctttttca ttaatttcta tattatattt tttatctaat tgagatacta
    23101 tatcttttat tttgcttaga ctcttgtgat aatcaagtgt tttttcttta tcaagctttt
    23161 caatttctct agtatttcca atcaacccat ctaccatgaa agctaaatgc atcataagtc
    23221 caattacttt atcgtatttc ttttctatat taaatactaa aaacaattca tcagacacat
    23281 attttatatc tttaaatatt ctattataat tagagctttt taaggatgtc tttaaacctt
    23341 caactacatc atcataacct atacttatct ttataatatt ttttaattta ttgatatttt
    23401 catccttatc tatatctttt ttgctaatat agtcaattcc tctaatatta attctttgtt
    23461 cattgattac tgcaacaata ttactacttt ctttaagttt cgtaatattt aaacttaaat
    23521 ctttttctgt tttatatggg acagatataa tatctattcc atctaagtac ctactcatct
    23581 tttcttctaa tatttttctt gttttattat ctacaccttc tgaaacatgt gatgctataa
    23641 taattgtttt agacagattt tctttatttt gaatttcatt agttccaaaa tagtgctttc
    23701 tcgtgttagt gatagagttg tatacgtcat ttaaaggtaa tcccatattg gccttctgaa
    23761 ctgcttctaa cacagttaat gtcgtcacca taggaattac tcttactcca cacttttttt
    23821 ctttctttat aatttcatca aaggagttta atgaacccat atctgtaaat agtaatacat
    23881 ctttattgtc tatattatta attaaatttt taaaatctac aataacttca tcatagcttt
    23941 tatctaactt catatcgaaa gaaatagcac tgcactttcc aataatatca ccaactgctt
    24001 ttaccatact acttgctgta gtttctccat gcatagcaac tataatatta atgttattca
    24061 ctattttatt ttgttcatct tgtttagctt gtactatgaa taatgtaata tatgctacag
    24121 tttctataga taaaaataaa tcaaattcat tttcaattat tccaactatt tttaatgctg
    24181 ttttaaattc acttctgtta tttcttctaa tttgattcaa atctatgttg tttgtagagc
    24241 tacttttatc caatacgctt tttatataaa ttgccattga cttaaatatt gattcactta
    24301 tgtctatttc ttcatcttct ttaataattt gtcttattga ttcacacatg cttttaaact
    24361 taacattatt aaatagagaa gcatctgcta tattcatttc tacagattta ttaagattag
    24421 tatttactgc attaataata tttatatcat tgtagttaat aacttcttct tctcctaatg
    24481 acgtaaatac aaaatattct attccatgtg ttataacttc atctgcttta atagacttct
    24541 ctctataatc atcactcact tcatttatag atttatcaaa atattttttc tctatataaa
    24601 ctggttcttt attatctctt ttatatctta gatatccatt tgcaacagct aattttatat
    24661 cattttgaag ttgacctaca ttatttttac aatcataaag taatagtgat ttaattattt
    24721 ctttatgtac ttttattgaa atagaaatac tttttgattc ttccttgaaa aaatttttga
    24781 ctaattccat tctttcaatc attgtcctat ctctcaatga tggtatttct attttcattg
    24841 gtattcttct attgaatgta tctaatagtg ttgatgtcgg attttctgta gtagcacata
    24901 ttattaatac cttagactct ctttctttcg ttgcatctcc tagtctttta aatgttccct
    24961 tatctataaa agtaaacaac atttcttgac cttctgctgg tagtctatga atttcatcta
    25021 aaaatagtat ccctccattt gcaatttcca aaagaccttt tctggaagat tctgcacctg
    25081 tataagctcc ttgttctacc ccaaaaatat gtcccataag taattgtgca ttattagcat
    25141 aatcagcaca attaaatgtt acaaaaggag ctttattttt tctaattcca ctatctatag
    25201 aataatcgta catatatcta gcaatcatac tctttcctac tcctgtttct ccatagataa
    25261 tagtatgaag tccatttgta ggatagagca ttgcgacctt gcatttttct attataggtc
    25321 ttaaactatg ttctttacct attagtgttt caaaactatc tttttttatt ttgttttcta
    25381 cttttgttcc tttttttatg ccaagcaact cactttgtgt atcaagcaat tcattcttgt
    25441 taaggttaag atttgcaggg atataataca caggtcttcc ttttatcttc gtaaccatac
    25501 cctcattgaa taattggttt aaatatgtac ttatattgtt tcttgcaatt cctgtctttt
    25561 ctgataattg gttagctgta atcccttttt cattttccct atatgatgat tctaaaactt
    25621 tcattacttt atctttttta tatatcatta caagctcccc tacattatag tattttatta
    25681 actaaaaccc ctatacacac tttatttttt aataaactct tattctttaa ctaaggttat
    25741 aatttatcaa actttcctta ctttaaatta tagaaaatta ttgtagaaaa aataagatta
    25801 ttgctcattt tttctacatt actattttta attttatagt actttcttaa caacatactt
    25861 tacttgtttt taattttatt atatttgaat ttattatatt tgaaaagtag aaataaaaaa
    25921 ccctattttg gagtagtttt aaaatttctc caaaaatagg gttttagttt gtatttcaaa
    25981 taaatacctg ttcaagtatt tttatactaa acaactttta aattttgttg atatttattt
    26041 atttctgatt tagaagaata tacaaaatgt ccatctgaaa cctcaatcca acttaatgac
    26101 ttttcatttg aacaatcata tccattagaa ttatactcta ttctatttct tgacttagca
    26161 tatctagggt caggaacagg aattgcagaa agtagtgatt ttgtatatgg atgaatagga
    26221 ttattataca attcatttga atctgccaat tctactaatt ttccattata cataactcct
    26281 atacggtcac taatatgtct caccatagat aaatcatgag ctataaataa acaagttaaa
    26341 ttcttttctt gttgcaattt tttaaataaa tttactattt gtgcttgtat agacacatcc
    26401 aaagaagcta taggctcatc agctattata aattctgggt ctactgaaag agctcgtgct
    26461 atgccaatac gctgtctttg tccacctgaa aaatcagatg gatacttatt tgcataactt
    26521 ctatcaagtc ctactagctt tagcatctca tatactttat tcattctatc tgttttattt
    26581 ttacagatac cttgaatttt tagtggctct gaaattatat ctgcaattgt catacgtgga
    26641 tttaatgatg aagtagaatc ttgaaaaata atctgcatac ttttgtttac atcttttttt
    26701 ataaatttgt acgttttttt atctgatatg caatttcctt tgtaaattac ttctccacca
    26761 gtagattcat gtagtcttat tatagtttta ccagttgtag attttcctga acccgactct
    26821 cctaccaatc caaatatctc acccttatat atatcaaaac ttatatcatc aactgctttt
    26881 acagtagtac ttttgtccaa atgaaaatat tgctttaagt tttttatttc cagtattttt
    26941 tctctattca ttagaaatca cccttccaca atttactcta actggtacat ctacttcagg
    27001 tgcatctggg tgcaataacc aagttgctgc actatgtgta tcattaattt taaacattgg
    27061 tggctctttt tcataatcta tcttaagtgc atttttattc cttattgcaa aagcatctcc
    27121 ttttggtggg ttcaataaat ttggaggcat tccaggtata ttatataaat agtcatcctg
    27181 cgaatctaaa gtaggtaatg aacccaacaa cccccaagta tatggatgtc tagggtcata
    27241 aaatatatcc tctacagttc ctatttctac aatctttcct gcatacataa ctgctattct
    27301 atcagctata gttgcaacta ctcctaaatc atgagttata aatattattg acaaacctat
    27361 tttatgttgt aaatccttta ttaaatcaat tatttgagct tgtatagtta catctaaagc
    27421 agttgtaggt tcatcagcaa tcaatacatc tggattacaa gcaagtgcta tagctattac
    27481 tatacgttgt ctcattccac ctgaaaaatg atgtggaaat tgtttaaatc ttttctcagg
    27541 attatcaatt ccaaccaatt caataagctc tatggctctc ttttttgcct cacttttact
    27601 tataccttga tgaatgatta cagcttctgc aatttgcttt cctattgata tagttggatt
    27661 gagagatgtc atagggtctt gaaatatcat tgatatattc tttcctctta tatcttccat
    27721 ctctttttca gacttcttaa ccaaatcact tgatttaagt aaaacctctc catttttaat
    27781 atatccattg tatgggagta tcctcatcaa actcttacac agtacagatt tcccacaacc
    27841 agattctcca actatagcca atgtctcacc tttttttaga ttaaaagata catttcttac
    27901 agcctgaact tctccttctt ctactttaaa acttacagat agattattaa cctccaataa
    27961 atgttccaaa aaccatcaac ccctatgcta ttcaaacctt agggatatat ttttatccct
    28021 aaggtttcta attaatttca gtattattca attgtccagt cagctatgtt ccagaataca
    28081 cctacaccat gatgacctaa aactgtatca ggtgttaatc cttttatgtt tggttttcca
    28141 acatatattg catctatata agcaataaat gtataaggca tatccttagt catttctact
    28201 tggaattgtt tatataactt taatttttca tctttatctt ctgtttctct tgctttttga
    28261 agtattttat ctatagtagg attagagtaa gcactgtaat ttgcaccttt atctgttcca
    28321 aatactttat atgtatggtc atctgggtca aatggacttc cccaacctat taaatgagca
    28381 tcttgattag cccaatctgt ttcagttaca acaacagctt tagcatcaac accaatttct
    28441 tttaactgtt gtgcacatat tttagccata tcaactctaa cttggtcact ctcacctgct
    28501 gttatctcga aagctaactt agtaccttct ttttcataga ttccatcaga acctaatttc
    28561 caacctagct tttcaatttc ttgtttagct ttttctggat tatattcaaa cttttctata
    28621 tcaggattat tatatggtcc catttgtaaa ggtgaatatg ctggtacacc atgtcctaat
    28681 aatacactgt caactattgc ttttctatct attgcatagc ttaaagcatt tggtaatcct
    28741 ttagcttttt tatctttaaa gaatttagaa ttaaaattgt ataatatacc tctatagtcg
    28801 gctgttttca ttatatttac tttaaaattc ttttcgtctt tttcaaagtt agacatatct
    28861 ttaggagtta tttgagctag gtctaattct cctgatttta attgcattgc cttagcctta
    28921 tcatctggaa caatcttaaa gactacttta tctaatcctg gttcttttac aaaataatca
    28981 ctattcttaa caagtgttat actttgacct ttgtcccatt tttcaagttt aaatggtcca
    29041 gtacctattg gtttttgatt aaattcatca gtagctatat ccttaccctc caaagcatgt
    29101 tttggtaata ctcctactgt taaataatca agcattgctg tatttggagc ttttaaagta
    29161 atttttatag tattatcatt aaccacatca atttttgtta tatcttcata atttgatgct
    29221 atctcagaag cattatctgg attcattata gtttctattg taaacttaac atcatttgct
    29281 gtaaatttct ctccatcatg ccacttaaca tcatctctta aattaaaagt atatgtattt
    29341 gttgcctcat caaatttcca gtcctttgct agacaaggaa ccaccttatt attttcatca
    29401 tgagctgtta atccattaaa tattaacgaa tttatttctc catgttcata tagtgcagga
    29461 tttatacttg tatagtcatt acttccataa acaagcacct ttccatcttt aggcgtatct
    29521 gccttcttat ctttgtctcc tccactagaa caacctgcca ttagactaag tatcattact
    29581 aaacttaaaa cttttaactt ctttaatttc atgatgctcc cccttttgct ttttataaaa
    29641 tatttttcaa agctttgacc ccatttattt aaatagatat ttcaaatacc tcagtatttg
    29701 cttatttaat actcaaatgc tgatttataa attactagat tttttattat tattctttct
    29761 tatataatta cctatatttg ttatacacac caatgtggta accaaaaata tacccggaat
    29821 cagtataatc caccatctat ttgaaagtaa tgcttcctct gacaaagata acatacttcc
    29881 ccaagaaaca atttctattg gtaaaccaat tcctaaaaag ctaagtgtcg attcagtacc
    29941 aatagctgcg cctatgtttg ttacaaccat gaacattatt gatgccacaa aatttggaag
    30001 taaatgttgc tttaatacat agaagaatcc tcctcccatg ctcttagctg ctagtatgta
    30061 ttcgctattt tttatttgtc taacttctgt tctcactatc ttagatatat tcatccaact
    30121 tgttatccct attactatgg acatagatac tggatttgaa tttccaagta tagcttgtac
    30181 aaatattata attaatattg aaggtatact aagtatgatt tctgtaaacc tcatcattgc
    30241 atcatctacg agttcagatg ccgaaccact tatactacca taaacaattc ctataacagt
    30301 tgatattaca gtggaaaata gtcctataaa taaagatatt tttcctccat accatatcat
    30361 agaatatata tctctaccca ttgagtctgt tccaaataaa aaagttttat ttggagctaa
    30421 attagaactt gctaaatcca tgtatgttgg ttcatgtgtc attataaaag atgagaatac
    30481 acttccaatg actatgattg ataaaataat aattgatata tatggtaatt ctttaatttt
    30541 tttagataag gttttctttg tttctatatg ttcatcttct gctactaaaa tataattttc
    30601 tcctacaatt tcaaaatcac tatattgtgg cttcattagt atcacctcta tcatatttca
    30661 ttctagggtc tattttattg tttataattt gagctaacat attcccaaat actactaaag
    30721 cccctgttat taagcataaa actaataaca tattataatc atgatacttt gcactttcaa
    30781 aacaaagtgt tcctaaccca ggataagaaa aaactttttc aactacataa gttcctccta
    30841 gtatatgagg tatcgaaatg gccattatac taatatatga tggcattata tttctcaggc
    30901 aatgcttaaa aacaatagtt ctattattta aaccttttgc tttacataaa agcacataat
    30961 cttctcttat ttcctctagt aatttatttc ttatcatata tgtgtaatac catagatggc
    31021 ttaatataag tactgtaaga ggtaagatta gatgtgatat cctacttaat atactggact
    31081 cttctcccat tgaataagca ccactacttg gaagtatact taagtttata ctaaatataa
    31141 gtatgagtac taaggcaacc caaaatgatg gaatacagtt ggttattgtt cctaatttgc
    31201 atatgattct atcaatgagc ttatcttcat gtaatgtaca aaatattcct aacaataagg
    31261 ctagcacaaa ggtaagtata tatcctgaac cacctaatat tatagtgttt atatagacat
    31321 catttataac agaagtaaca ttttgtttat atttaaatga aattccaaat tccccttttg
    31381 atgcatttga aatccatttt atatattgac tgtatattgg ttcatccaaa ccaagttttt
    31441 tcatagcatt ttctttttct tgtgtactca ttctttctac tccatcccca tagtaagaga
    31501 ttaatgggtc tcctggagca agtcttgcca tgtaaaaaac aataaaagat aataaaaaca
    31561 ttactaaaat aaactgcaac aactttttca gtatatcctt taacaaaccc caacccccct
    31621 ttgttgcaat aaaaaaaacc acataaaagc aaacgtaaag taacgttaaa accttcgtgg
    31681 ttccattatc attaaacaaa attaaatttt ctatatttat ctatgagtta attttagcat
    31741 catttattaa ctgtgtaaac aaacttttta aaaattgtta aaatttcatc aaattatttt
    31801 atttatacct aaaataaaat ttttatattc tattcttcat tattttctat aaaattataa
    31861 aattttaggt tgactatata agaaaagtat attatattag tttgtatgca aaccatttaa
    31921 gaggtgattt tattgaaaag taattatgac tgttttagaa tagccatgct cttaaaagaa
    31981 ctttattcta aaactatgta cacagtagaa gaaaatttta aagaaaatgg attaacacac
    32041 caacagatta tagttataaa actgatagct cataatcaag aacttacaat atcacaacta
    32101 tgtgatgaaa tgtctttagc taaaggtacg gtttcaggca taatcagcag attagaacag
    32161 attggatata tagaaaaatt caagaaatct aatgataaaa gaaatacata cgttaagttt
    32221 acaacaacag gatttgaatt tgccacaaat tttaaaatta aaatgcaaga aagttttgat
    32281 gatattttta aaaattgtga tgaaaacgaa ttgagtgact tagtaaaaaa tcttagaaat
    32341 atattggcaa aagtaaagga gagataatta tgaattataa attaatactt gcaatagtat
    32401 ttataacatc agctttaatt ttctacacta taggtgtatt tggagaaaga aaggcaaaaa
    32461 ttttaaaaaa gaaacatgta attatatttt ggcttggttt tatatttgat actttaggaa
    32521 catttacaat gagtaacata gccaacagcc atacttttga agtaaaatct gctttatcac
    32581 aaaaccttca tagtattaca ggtcttcttg caattgtgct tatgcttttt catgcaagtt
    32641 gggctacttt tgtcctatac aaagatgatg aggaaaagaa aaaattcttt cataagttta
    32701 gtatagttgt atggactata tggttagttc catattttat aggtatgttt attggtatgg
    32761 ctggatagta aaataaaaag tgtgtaagaa atactgtagg taaatttgta taagacaaat
    32821 ttatctacat ccttctttca cacttttaca tatttattta taatactcca ttatttcttt
    32881 catgtttctt aatacctata tagaatattt aattatttct atagtatttt attattttct
    32941 cacacttttt catatatata ttgttttact atttcttcat atgtatatat gaaatattcc
    33001 attatttcta taaatgtttt attatctttc tcatactttt tcatatatat attgcttcac
    33061 tattttttct tatttcttca tatacatatg aaatatttca ttatttctat aatgttttat
    33121 tatctttctc atactttttc atatatattg cttcactatt ttttttactt ctttattaaa
    33181 tacttatgta taacatacat ttaataaacg ctaactatta aacacctaat acttgagtta
    33241 ctcctggaac ttcactcacc aaaacatttt caataatagc tttgattgtc atagtcgctc
    33301 ctggacaccc actacatgcc ccttgtagtc taactaaaac cacaccattt tcatttacat
    33361 ctataagctc tacatctcca ccatctcttt gtaatactgg ttttatcttt tcctcaagca
    33421 ctttttcaac tttttctctc atagctattc cccccagaaa tattttatta gcaaaattat
    33481 accaatggtt taaatttttg tccatctaat gatttatcaa attcaatttt tgcttcatca
    33541 ataattttag tatccataaa tacatcataa gcactacaag ccagtacttt agctgaattt
    33601 atcatagcag aaaatcctat atttgaacct gctgatgaac atgactgcca tgtatgactt
    33661 gcaattccaa caggccaagc tgccattgca aattgagcca ctggtattac ataacttaca
    33721 tctccaacat cagtagaacc agctagtcct ttatctttgt caccgtcaac tatttccttg
    33781 tgtatatagc tttctacaat agatttatca ttttgtaatg atgttgctac acctaatctt
    33841 tcttctctag taagagtatc acacaacttt tttgcaaatt cttcttcttc aggagtattt
    33901 ttagggcaac caacaaaaac catattgtca taaactaaat cagtcaaaca ttggtttggt
    33961 atatagtcat atattccatc tgtaacctta tactccattt cagtttctgt catcattgct
    34021 gctccttgag ctacttttat taatctatca agaacgtgtt ctgcatcctt tgctttttta
    34081 cctctaataa agtaccaact ttcagcaaat ccaggaacta cattaggtct tccaccacca
    34141 ttagttataa catagtgcat tcttatagag tcaataacat gttctctcaa ataattagct
    34201 ccaacattca taatttcaac agcatcaagt gcgcttctac cattatgagg agcttgagct
    34261 gcatgggctg ttatcccttt aaatttaaat tttacagata agtttgccag acttccacct
    34321 ctccaaggtg catttatatc aaaaggatgc catgtaaatg cacaatctac atcatcaaaa
    34381 cagccattta tacacatagc tgtctttcct ccaccttctt cttcagcagg acaaccaaaa
    34441 tattttattg ttccattaaa tttattttct tctattaatt tttttataga aacaactgct
    34501 cctacacctg ctacacccaa caggttgtgc ccacatccat gtccagcttt tccttctacc
    34561 aatggctttc tttctgcact tacacattgt gatagctctg gtaaagcatc atattctcca
    34621 agtatgccaa tcacaggttt accctctcca aaacttgcta taaatccagt aggtaaattt
    34681 tctacttctt caattttaaa tccttttgac tttaggtatt ctttttgaat gctacttgca
    34741 tacttttctt caaaggctaa ttctggattt tcccatattt tcttagataa atcaattaat
    34801 tcttctctta tttcttcaac attatttatg atatactctt tcataatttt cctccaaata
    34861 tatgtatttt tgatatgctt tacagattat attatatact aacattctat ttattcacaa
    34921 ttttttgtta attaatttta ttcatatgct cttctatgga gtatatctta tcttcacttt
    34981 gcctcttcat aaatttaatg tactctatct tccataaagt agtttcagtt ttctcattta
    35041 acataaattc taatatatta atttctctca ttctaatatc ttcataaaat actacactac
    35101 ccaatattgc caattctaat tcacttaatg atgcaaacaa cattaaatac tcttctccaa
    35161 ataaacattc agattcaaga atatcgataa agtctttttt agcattgata ttttccttta
    35221 ttattcttat tttttcaatt atagatgtac tatctaatat ctcattgaat atctctctaa
    35281 acgattcatc atccaattta ctttcatcat caacaatata atcttctaag tgttcctttt
    35341 tatttttact cacagttacc atacttttaa aagtgttact ttttattgag cttagcacag
    35401 attcaataaa tatcttttca tattttttaa tatatcttat tacatcttca tcttctatgc
    35461 ttaatctttt tattaatact tcaattgctt ccataagtag taaagttatt tttttattta
    35521 ttctaatttc tctgttaatt tcttcaaaat cattataatc caaattacta tctacttcag
    35581 tgttaaaact atcatctact tcaatcaatt caattatatt actttcttca gagtctataa
    35641 ctttatcttc agtaatatta ttgtacatat ttttaaattg tttttctaaa aattcatact
    35701 catattttga aatttctaaa ttagtcactt catttcctaa aatagtagaa aaaatacaat
    35761 tatttataat aagttcaaat aaatttacaa gtatagcatc acaatctatt ttataagtca
    35821 ccccatagtc ataaaataat ttttctctat cttttttctt aaataggtta caaaatctat
    35881 tttctatatc tatactctca atataattct tcacataata aataccctta acatccatat
    35941 catctagtgc caatggataa tctatactta ctggaacgtc ctgagcttca aattttacaa
    36001 tataactttt aaagaaactt gataactcca tcaaggtatc attatatgct attgaattag
    36061 tatccaattt tctactcatc attagtttat aaaaatcttt tagcctaact aactcttcct
    36121 ctaatatttc aatgcctcca aggtacactt ttttaacatt cttagcagtc aactccacaa
    36181 ctcttttttc tatatcccca agcttattta tatatgcatc aatagcatac catattgaaa
    36241 tcaacagttt ttcggcaact tctgttttta ctgatgtgct ttgaccattt gtatattttt
    36301 taatcaaatc cataagtatt agagatattt cttgttgtat attatatact tctctttcat
    36361 ctatcacttt acaatttaga cattccttaa gtagagatat ggaatattgg ttctttatta
    36421 aattattttc gtttatatta atattactta aattatttaa catacaaaat ctctcctatc
    36481 atatattaaa cttctccaaa tttaaatttc tttgcaaatt cgtctgcttc tcctcttaca
    36541 ttgtccatat tgcctgaaaa tttttcataa aattcaccca gtatttctat aatctcatca
    36601 tcacatatct tgtcatcagt ttcatttttt aaataataaa aaatttcttg catatcatta
    36661 atagcctcta aataattgtc cacatttgta tattgtgatg tatatatatt ttctattaac
    36721 tgttttgtaa cttttatatc taattctatt cttccatacc cctttaaagt attatctctc
    36781 gaatttatta tatcttttac atcagattca gaaagagcta gaccataatc tccagattct
    36841 atattagttt caagcagttc atttctttct atttccttta aattctgatt tatagaactc
    36901 aaaataatag gtgatatcat ttttaaattc tcctttttta ttttttccat tgactttttt
    36961 tgttttttat gctatactta aattaattta tattatttta ccaaccactt ataatagtag
    37021 tgttaaaagt ggtttttgtc aactcaaaat tactatctca attaaacttt tcaattttct
    37081 caacaaaaaa ataccatcat ttagatatat aactttctat aacaactttt aattcagtag
    37141 ttatttacta aaatctaaac aatgatatat ttattaattt tatttatctt ttttggctct
    37201 acttctactt ttctttacat ttgagcaatt tctacaagaa ggtgaacagt attgagattt
    37261 agaatttgta ggaatataaa ttttaccaca gtacttgcat ttatttaaag aagaaggttc
    37321 acttgtaatt gcaaaggcat agatagtctc aatagctgtt ttcaaagaat caaactccca
    37381 tgcaataatt ggtttatcta attggcttat agaaaatcct atcttttgag gattaaaccc
    37441 tccagacata atagtaacac tttcagttaa tagattagat gtatttttat atacacaaat
    37501 ttgattaaaa tgcttacaca tatctttagc aaaacttaca atccaatcta gttgttcagt
    37561 gtagaacttt gaaaatacta aatctaaaat caatggtctc tttccaaaaa actttggaga
    37621 ttcttctctc tttgatacat ctatacccct tctatacttt ttaaaataca catcttcatc
    37681 acttgcaaat ggtataaaca tgtttacata ttcatctgta ctcaatatat tctcttttgt
    37741 aatataattc ttttcaatca tcagtactct ttcttctcca actatatctc tattatatac
    37801 acttgaatat attaaaccca ataatccata cttttttaca aattcaagta cttctttctt
    37861 tagtttcatt tcttttgtct cttttgatat atcttgtaat gcctcttgtc ctatgcgaat
    37921 tatatctact attatatcat ctgctacatc aaatgggtta tacatggtaa acacagcatc
    37981 ttctgttgga actatatata attcatcttc ttcagtaatt ttatattcat aatcactata
    38041 cctaatccaa tcacttgcaa aattccctat taattctatt tttttattca taataatcat
    38101 tcacaccttt caatgtaata tataatttca tattactatt acacttttag tttattccat
    38161 attttctaca ctgtcaacta ttctttttat atttttagca tattaaaatt tataatagcc
    38221 tttataatgg atttctagag ctaaatttct tgtttattga tgactaattc ataattaaat
    38281 ttataaaaac tatttacata taaaattaat ctctttataa ttgatatgta atatattttt
    38341 acacttacat attacatatc aattataaag agaggtatct aaaatcatgg atagaaaacg
    38401 tgaattaaaa caattataca aagaaatgaa atttgacaca ggtgtattca taataaaaaa
    38461 tgatattact aaaaagattt accttggaaa aagtaatgac ataaaaagca aatttaactc
    38521 tctcaaattt cagcttggtg ctggctcatg tatgataaaa gaattaaata atgaatggaa
    38581 aaaatatggt gaaaaagcat ttacatttga agttttagaa cttataaaac atgatgataa
    38641 caaaacagag aaagattatt tagaagaact agatatttta gagatggttt ggttagaaaa
    38701 attaaaggaa gataatactt atgaaattta ttccatataa aaaatcatat aatataagaa
    38761 aaggagatag tatatcaaaa tagacattta gttcataaga tactttttta tataaaataa
    38821 agtatctttt cataatttta acaatgaaaa agaggcttat ctccatttga tagcctcttc
    38881 ccatatattt tataccatta taaaatgaac aatctactaa ttttcaatgt gtatattcat
    38941 tttactaata acactccatt acttctttac agcatccaaa cattgctcta taatactctt
    39001 atcacttata cctattgctg ttactttact agctccactt aatatactct tatcactttt
    39061 atttgaaact aaaacaacag gagcattttt tgcaagtggt gatgcaacta aagcataaac
    39121 taaatcgtct ccacttgtta tatagaactc ttttgctcca ttatagaact tttcaataac
    39181 atttttatta gtttgatatc tatcaacacc accaattcta gttgctctat atctgctcac
    39241 tatgtaatca cttaatgtag actctcctcc aatagcatat actggaacag gagaaactcc
    39301 aaaccatggg tctaagtctg tgtcttcttc tgctgaaggt atatcttttg tcaatattat
    39361 aggagctcca tctctataag caacagatgc aacacttact gcatcagctt catccttaaa
    39421 tccatttact aaaaacatct tatcactgtt tttaattttt tctatttcac ctgcaatttt
    39481 ataacttgta tctactctat ctacaccatc aattcttata acttgcattc ttctcataag
    39541 taacattttt tctacatctt tacttataga attttctcca cctattacat atatcttagt
    39601 aactctattc agtctttgaa gcgttgcttc tggtatatca tccttattag ttaataaaat
    39661 agctgcatta tttactcctg caagaccact tgcagcaatc ccatctacca ttgtagaatc
    39721 tgcattgata agaactgctg ttgtaaaatc ttgcttatct gaaataagcc cagctgtttc
    39781 atatttatct actccttgaa tattttcaat cttatctagt gcgtttattg atgttggaaa
    39841 actaacactt aacagtaatg ctgaaatacc taacgccaat acctttttac taatcctcat
    39901 aaattacctc cctaaaacaa atatatttag tattagtata atataaaatc atttaaaaat
    39961 agtgtaaaaa tagttacact tttttataat ttaaataatt ttagattaaa cacaattcat
    40021 ccattaaaat aacttcattt attctatatg ctaagccatc ccacgttttt tttgacatat
    40081 ctacagatgt tttcttattt gagttattca ataaagattg tatcttagaa tctattgcat
    40141 tatacaaatt attttcaaaa tcatataact cttcatcttt tggaatacct tctttctcca
    40201 taaaaggtag agaaacatat tctatctttc cagaattatt aatctcacta ccaatccact
    40261 ctttaacacc aagaatatca gtagtgatta catctgtgcc acaagataaa gcttctaaaa
    40321 ctacaactgg taatccctca taaaatgatg gtaacacaaa tatttgtgac ctgttgaata
    40381 gctcagctaa atctctctgt tctaactttc ctaggaaatt cattttaaat ggagacttac
    40441 ttgccagttt aactatctca ttatatgatt cgatatcgct tccagtacct gcaaaattga
    40501 cttctattaa atctttacta tattttaatt tagatatagc ttttataaat ggaatcagtc
    40561 cctttgattt acatatctta cctgcaaata ctatttttat tttatcatcc tttattttat
    40621 aatttttatt ataaaatata tcatcattat aaccactacc aattacaact actttacttt
    40681 gacttactcc aaaagtcttt ataatatcat atttctgatt ttcatgaaga gcaaatatta
    40741 aatctaattt ccttatattt gctattatgt attctttctc taaatcaatg gtatttaact
    40801 gtcttaaaca agttccatga caaatagaca taacctttat atcttttacc atttccctaa
    40861 caaatgcagt taaaaggtac aaatgatgac atattataag ttctggttta aaatcattca
    40921 tagccttatc tatatttact ttaaattgat atttcaatct atttatcatg tctatattta
    40981 aatctttata tcttgtactt tcatatggca tagaatcact catacctaca acaggaaaat
    41041 ttaactcccc acaattatac tttactggat aaaaacttac ttcacttgga aaacaattta
    41101 catcatcatt tacatctata cctgcaatta cagcttgctt atgaccgatt ttttcgaatc
    41161 cttttatcat accagacaaa tatataccac tacctgtact atttggtttt tgtgttatta
    41221 tatgaagaat tttcactttt cacttgcctc ctttctaaaa ttaaatagtt ttatacagtc
    41281 taatcattat atatatctaa atataaacaa gatgaatcat cttttacttt aaatcttggc
    41341 actttaaccg ctttatagtc attatcttca aaatccctta ctttattatg tatatatcct
    41401 ataccaaatt tttctgctat acgtatcaat tcttcttctt ttattagatt atatctatca
    41461 catgcacttg taaaaccatc actcgttagc atcaattgaa aatctttttt tatttcaatg
    41521 tatccatata tagaattttc cacagcttcc tcatcaaaat ccaatatcca atagccctct
    41581 tttgtatttt tcttcaatct attgcttact attgtatcca taacactagt tctaatctca
    41641 tcaaatgcca tctcttccaa gttagaaagt ttactcattt catcaaatac agtattatca
    41701 aatttacaaa tactcctatc ttttataact ttggaatctc catttttaat aaacaaagca
    41761 caatctccta ataaaaaata ctctacttta ttttcatgaa attttacaac aactatagaa
    41821 ctagatggta aatctaattt ttcaacctta aacccattta atcttagttc atactctttt
    41881 tttacttcta ttattccagt attaataata ctctttaatg attcttcttt atttatattt
    41941 ttatataaat acctattcca ccactgaaca taccaccttg cgtcactttc agttgacact
    42001 aaattttttc cattaagtcc tgtagcacca tctaaaaccc atgccccaaa tggatttata
    42061 ccgactacat cttcattaaa tttagctgtt ccttgattac ataataggct atagtttctt
    42121 atatttaaag ccatatcaac ctccaaattg aatatctaaa aataaagttc tatttaaaat
    42181 tatacagcaa ataaaaaaat ctacaacaaa acttgttgta gatttttact taatctatat
    42241 tatctttata ctttcagtat tttaatgatg gaataatcta ttcttagtaa atgccatgac
    42301 tatgttatac ttattacaag ttaatataac attatcatca cgaatagaac cacctggttg
    42361 tgctataaaa cttaccccac ttctttttgc acgttctata ttatctccaa atgggaaaaa
    42421 tgcatctgaa ccaagtgcta ctcctgttaa agttttaagc catgctcttt ttccttctcc
    42481 agttagaggc tctggttttt cttcaaaaaa gttttgccat atgccatcag caagcacatc
    42541 catataatca tcagaaagat atacatcaat agtgttatct ctatctggac gacctatatc
    42601 ctttttaaat tttaagttta atactttagg atgttgacga agataccaag tatcagcttt
    42661 gttacctgca agtctagtac aatgaatacg tgattgttga cctgcaccta cccctattac
    42721 ttgtccatct ttagcataac aaacagaatt tgattgtgta tattttaatg taataagagc
    42781 tataattaaa tcacgttttg cactatctgt aaaaatttta ttatcagttg gaatatcttt
    42841 taataggtct tcatttatta atatttcatt tctaccttgt tcaaaagtaa ttccataaac
    42901 atcctttgtt tcaataggtt caggagtata attttcatct atttttacaa tattatagtt
    42961 gcctttacgc tttcctttta atatttcaag ggcttcatct gtatatcctg gagctattat
    43021 accatcagaa acctctcttg ctataatagt tgcagtctcc ttatcacata catctgaaag
    43081 tgctataaaa tcgccataag aagacattct atctgctcct cttgccattg cataagcaca
    43141 agctaatgga gaaagctcta aatcatcaac aaaatatatt tgctttaaag tatctgataa
    43201 aggtacccct actgctgctc ctgctggact tacatgttta aatgaagttg ctgctggaag
    43261 acctgtagct tcttttaatt ccttcacaag ttgccaacta ttaaatgcat ctaaaaaatt
    43321 tatgtatcca ggttttccat ttaatacctc tataggaagt tctccattct tcatataaat
    43381 ctttgatggt ttttgatttg gattacagcc atactttaat tctagttctc ttgccatata
    43441 ctcatccctc tctataataa attaatcata agtttgatta atcctatatt aattaaatta
    43501 ttcgtactaa taaaattata tggcatattt atccattaat caactatatt ttttaaaact
    43561 cctattcctt cgactttaca ttcaactata tcgccatgct ttaaatatac ttgaggattc
    43621 atccccatag caacccctgc tggagttcca gttgaaatta tatctcctgg ctttagagtc
    43681 attcctcttg ataaatcatt tattatagta ggtatatcaa atataaagta ctctgtatta
    43741 gaatcttgtc ttacttctcc atttactaca ctacttatat ctaattttaa aggatgttca
    43801 aattcttctt tatgtactat acaaggtccc atagatgtat gtgtgtctaa gctttttcct
    43861 ctaaaccatt gaacatgttt atcttgaagt gctctttcac ttatatcatt tactattgta
    43921 tatccaaata tatattcata agcatcttct tttgatatat ttataccttc tttacctatg
    43981 attactgcaa gttctgattc atagtccaac ttctctacca aatctccatg taagcttatc
    44041 ttatcatcca ctccaattat tttgtctgct ctcttagaaa aataaattgg ataatctggc
    44101 ataactacgt tttttataac tccatctggg atttcattga catggtcttt atagtttaga
    44161 cctaaacata taatatcttt tttaggtctt acaattgggg aacataattt aacttcttct
    44221 aacttataac actttgcgtt ttcaaatgaa ttgtttttta ttttttctaa atctcctgta
    44281 gatacgtttt caataaaatc attcatatca gtatataatt tacttaatcc taaactatta
    44341 atttcatata tactatttgt ttctgaatta aatacaccta ttttttcttc attgctacta
    44401 caaaaagtca caaatttcat ttttattcc
//
LOCUS       DAEPID010000029        43324 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.029, whole genome shotgun sequence.
ACCESSION   DAEPID010000029 DAEPID010000000
VERSION     DAEPID010000029.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 43324)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 43324)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..43324
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.029"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            <1..606
                     /locus_tag="KR257_001723"
     CDS             <1..606
                     /locus_tag="KR257_001723"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860758.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="conjugal transfer protein"
                     /protein_id="HBH0030427.1"
                     /translation="ISGYLTKKLQDLNVDTIRTDILTSPTVTDVIVWNIEQSGTDTFS
                     ATYEVDQQIKEGEQTTTVKATYTVKVHVDADRDMVIIQNPTLAPAIEKSDYEPKTPEA
                     DASVDADTVNDATAFLETFFKLYPTATAKELAYYVFGNVLEPIGRDYLYSELVNPVLT
                     KDGDNMKVKVAVKFLDNQTKATQVLQYELILHKDSNWKIIM"
     gene            819..1676
                     /locus_tag="KR257_001724"
     CDS             819..1676
                     /locus_tag="KR257_001724"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002585362.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha/beta hydrolase"
                     /protein_id="HBH0030428.1"
                     /translation="MYKEVGISSNNVPITLSIWYTERSSPTIVFLPGTMSHPLMYENF
                     LCGLSERGFNIIGIHYLSHGKSPKIKKNYTMEDLLHNVYDATTYGIENFGENIAVMGS
                     SQGGILAAMAAGRDTRLKAVFPHNIMLTTLKETMSLTKYPTWSHRFMGLIQWGFRVGG
                     KLLPNYKVPGDAYLDYDRVFYSEQAKQDCLNDPMLLPYYPLRFVTSLFNADLSCLENG
                     AIQCPVILITAKGDPLFSFDYTNKVFDLIHVPQKELLALELNRHMIFNEDTDTTINAL
                     EATLHKYLG"
     gene            1754..2335
                     /locus_tag="KR257_001725"
     CDS             1754..2335
                     /locus_tag="KR257_001725"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902354.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="HBH0030429.1"
                     /translation="MPRFTEQEKEIINSKLLIEGEKLFALHGLKKVTVDDLVAAVNIS
                     KGSFYAFYPSKEHLYVEINFRLQKELFTSIETTIKKKKYKNHRDLAKDVIMLSLTGVI
                     TSPILSQIDLSLMDYLQRKISSDIFENHMYSDIRILEILEDLGVVFLVPHTVIIKSLY
                     SVLSCLEQFKEDEELNMIQNLLVNGIIQQVVAE"
     gene            2439..3284
                     /locus_tag="KR257_001726"
     CDS             2439..3284
                     /locus_tag="KR257_001726"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892238.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBH0030430.1"
                     /translation="MIDVKKLYFSYTDKPFVENVSFHVGRGEIFGFLGPSGAGKSTIQ
                     KVLTGLNTRYKGSVKVAGTEIREHTNQFYENIGVDFEFSTCYEKFTARQNLAYFASLY
                     EKQPRSIDELLHMVGLENDGDKKVADFSKGMRSRLNFIKALVHDPDILFLDEPTSGLD
                     PTNSRLMKDIILAEKKRGKTIIITTHNMFDATELCDQVAFIVAGKVSALDSPHNLIMS
                     RGAAKIQYTYYDKGEKTGECLLDRTTEDKLLKSLISENRLLSIHSSEPTLNDIFVDIT
                     GRTLQ"
     gene            3281..3964
                     /locus_tag="KR257_001727"
     CDS             3281..3964
                     /locus_tag="KR257_001727"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016295773.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBH0030431.1"
                     /translation="MRLGRLICGDIHFQWKYGFYFIYFILTVLYVCGIAALPEHWKTD
                     IASIMIYSDPAAMGLFFMGAIVLLEKSQKVLNAMVVSPVKISEYILSKTVALIAISTV
                     IALILGVVSGSNHLLGIAVGTALTSAIFTMLGIIAATKISNLNQFLIVIMPIEIICFV
                     PPIVGLFVKLPYLFRFFPFTACMNLITGKSVLLSFDMVLVIATLIILYIVARHTVEHM
                     WKSLGGVKL"
     gene            3961..4659
                     /locus_tag="KR257_001728"
     CDS             3961..4659
                     /locus_tag="KR257_001728"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002583502.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBH0030432.1"
                     /translation="MKKILSSTIQIFKQIKSDPMMFAACFSPFIMGTLIKFGIPFLER
                     ITKFSLQAYYPIFDLLLSIMAPVLLCFAFAMITLEEIDDKVSRYFSITPLGKSGYLFT
                     RLGVPSIISAVIAFIVLLLFSLEKLSIGMTICLALLGSVQAIIVSLMIITLSSNKLEG
                     MAVTKLAALTLLGIPAPFFIDSYYQFAVGFLPSFWVAKAMQNEAVLYFSIGLVVALVW
                     YYFLTKRLFRKLAG"
     gene            4671..5582
                     /locus_tag="KR257_001729"
     CDS             4671..5582
                     /locus_tag="KR257_001729"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434337.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cation transporter"
                     /protein_id="HBH0030433.1"
                     /translation="MEKGRLLQNKNMNKAIQVSKITLIINLSLSLLKFAAGYIGKSSA
                     MLSDAVHSASDVVSTIVVMVGIKISEKQPDREHPYGHERMECVASIILSVALAITGAG
                     IGYSGIKKIFSGQYNTLSVPSGIALTAAVLSIVIKEWMYWFTRSAAKHTNSDALMADA
                     WHHRSDALSSVGSLIGILGARLGYAILDPIASVVICGCILKAALNIFKESINKMVDHS
                     CDNATETRIREVVLQQQGVDGIDELKTRMFGAKMYVDIEILADGNLALYDAHRIAEGV
                     HQTIENNFPQCKHCMVHVNTNELLYSA"
     gene            5634..5774
                     /locus_tag="KR257_001730"
     CDS             5634..5774
                     /locus_tag="KR257_001730"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016295776.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0030434.1"
                     /translation="MEQYWWIIIVVVLIVVGLLKIVIMKKYNQRRNSNNRSKDSEDDK
                     MY"
     gene            6065..6691
                     /locus_tag="KR257_001731"
     CDS             6065..6691
                     /locus_tag="KR257_001731"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434340.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="HBH0030435.1"
                     /translation="MSDTKENILKIALHLFAVNGYEAVSVSMIAEALGMTKGALYKHY
                     KNKQDIFDCIVERMYQIDNKRAKDYQVPESTIEVTPNAYRNTTIGSLITFTLAQYDFW
                     VTDEFASNFRKMLILEQYRNLKMNMLYQKCLVNGPISYIEDIFNEMIEKGVLQECDTK
                     QLAIEYYAPLFLLISVADAVENCWDLKTQLTTHVKQFVKKYIINEKVK"
     gene            6813..7529
                     /locus_tag="KR257_001732"
     CDS             6813..7529
                     /locus_tag="KR257_001732"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434342.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="methyltransferase domain-containing protein"
                     /protein_id="HBH0030436.1"
                     /translation="MEYIRSKKYFTPDLQTKIMGPNPIKLQEELLQNHKIPSGSYVCD
                     LGSGQGLTSVFLAKEYGFVVFAVDLWSEPKENEEFFKKMGLSSAQIKSVKADANELKF
                     EKEFFDAVVSTDSYNYFGRDPIYLDEKLLPFVKKGGFVYITVPGMKKDCHEKLPEELL
                     LSWTPEELDYIHDITYWSNIISHCKKADLISIYEMESNSEVWSDWIKQNNEYAINDRK
                     AIEAGGGDYLNFIAIILQKK"
     gene            7679..8275
                     /locus_tag="KR257_001733"
     CDS             7679..8275
                     /locus_tag="KR257_001733"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015541496.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF998 domain-containing protein"
                     /protein_id="HBH0030437.1"
                     /translation="MKILWIIIIMADNLLPLLLARFYPNYKHKEMALSVLGSRQSPVK
                     WIYNVWCIISGVVFCIAPYALYQENDSGWAIAIWMLLAIYGIGCEIISGVCPLNENRQ
                     DEDIITKIHGGTSAIGFMALLVVPLLFAILQFQTTKVVLGAISLVCFTIAFIFFCFFI
                     MGEKEKFANTVLRYGGLWQRLVLISCYIPLFVWSVSNQ"
     gene            8362..8553
                     /locus_tag="KR257_001734"
     CDS             8362..8553
                     /locus_tag="KR257_001734"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003064779.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4177 domain-containing protein"
                     /protein_id="HBH0030438.1"
                     /translation="MKKYEYVEINYNAKGVVFLCTDKHKEIIDSYAKTGYHYAGFVPT
                     EIDAKGCMRKIDLIFEKED"
     gene            8577..8807
                     /locus_tag="KR257_001735"
     CDS             8577..8807
                     /locus_tag="KR257_001735"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434346.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0030439.1"
                     /translation="MIGLKRRDMNYIMKVGAKAQGVSVSEFRAMLQDTIDKTMESTDP
                     DVQANFKRYFGNKRPTPEEYIYTITKKTKVKV"
     gene            9074..9493
                     /locus_tag="KR257_001736"
     CDS             9074..9493
                     /locus_tag="KR257_001736"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009261829.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sigma-70 family RNA polymerase sigma factor"
                     /protein_id="HBH0030440.1"
                     /translation="MKPSDFQKTIQCQFECKLKKVVKGIIWNYRKELKRRKNKEISFS
                     ELPDITVESLATWDDYETNYTIFNVCGIDIKVLDDELAEALKQLPEKKRNNVLMYYFL
                     EMSDTEIADIMNYTRGAVFKHRHRALETMKEILKEKK"
     gene            9496..9750
                     /locus_tag="KR257_001737"
     CDS             9496..9750
                     /locus_tag="KR257_001737"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438724.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="HBH0030441.1"
                     /translation="MKKKYKHPSYYLISSAMDGDETAIEKLLAFYDPYISKCCLRPLY
                     DEYGNVYIVVDMELKGRIREALIKMILDFEIDIDIETEEE"
     gene            10125..10328
                     /locus_tag="KR257_001738"
     CDS             10125..10328
                     /locus_tag="KR257_001738"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002347229.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="excisionase"
                     /protein_id="HBH0030442.1"
                     /translation="MNNTDVPIWEKYTLSIEEASRYFRIGEKKLRKLAEENLDSGWVI
                     VNGNRIQIKRKQFEKIIDTLDEI"
     gene            10406..11596
                     /locus_tag="KR257_001739"
     CDS             10406..11596
                     /locus_tag="KR257_001739"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006354938.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="site-specific integrase"
                     /protein_id="HBH0030443.1"
                     /translation="MSKMKRQDSKGRNLRLGESQRKDGRYVYKYTDIFGKPQFVYAWK
                     LVPTDKTPTGKRDDKSLREKEKQIKKDLDDGIDTIGGKMTVCQLYAKKNNQKKNIKRN
                     TEIGRQYLMNALENDPLGMRAIDTVKQSDAKEWAIRMNDKGYSYKTIDNYKRSLKASF
                     YMAIQDDCIRKNPFHFKLSDVLEDDTEPKVILTPEQEEKLLSFMETDNVYSKYRDEVI
                     LLLETGLRISELCGLTTHIDMLNRVINIDHQLLRDTEVGYYISTPKTKNGKRELPLTE
                     RAYQALERILKNRGKAQPLVVDGYSNFLFLNREGLPKVAGNYESMVRGLIKKYNKTHE
                     DKLPNITPHSFRHTYCTNMANKGMNPNTLQYIMGHANITMTLGYYAHGTFQSAKAELE
                     RLAS"
     gene            complement(11853..12653)
                     /locus_tag="KR257_001740"
     CDS             complement(11853..12653)
                     /locus_tag="KR257_001740"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861383.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBH0030444.1"
                     /translation="MRLNKRSEGYINYVKGVKREKRNVLFYQLLILIGFIVIWELLAD
                     LNVINTFLFSKPSDIYNLFIQYAFSGQLFKHIGISVYETVLGLVIGTVLGILVAIALW
                     WSEKLSKILDPFLVVLNALPKTALAPIIIVWVGAGIEGIVVTAVTISVVVTILSAYNY
                     FMNIDEEKIKMLKSFGATKSQILFKLILPANTGNLINLTKINIGMAWVGVIVGEFLVS
                     RYGIGYLIVYGSQVFKLDLVMMGVFVLAICAWAMYAVVNIIEKIYNSR"
     gene            complement(12848..14446)
                     /locus_tag="KR257_001741"
     CDS             complement(12848..14446)
                     /locus_tag="KR257_001741"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435445.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
                     /protein_id="HBH0030445.1"
                     /translation="MKAAIYSRKSRFTGKGDSIENQIQLCIDYAKSIGVKDFLIYEDE
                     GFSGSNIDRPQFKKMMQDAKDKKFSYLVCYRLDRISRNVSDFSTLIEKLNELSISFIS
                     IKEQFDTSTPMGRAMMFISSVFAQLERETIAERIKDNMYELARSGRWLGGNTPHGFNS
                     EKITFLDENLKERSMYKLQVNDEQMEIVKLIYNKYLELRSLSKLYKYVYNNGIRGPRG
                     GKFDPSSLSRILRNPAYVKANDEILDYLKNSGMDVVGTPDRKCGILTYAKNTSNSIAA
                     IAKHHGVIEPEIWLEVQNQLDKNRDKTPRISTGKTALLSGLIKCGKCGSNMRITYKGK
                     KTDKDLKYYYICGTKKTLGSDSCNCKNLNGPLVESLVIDKIKNCKEESIISAFNSNNI
                     KTDNVFNIFKSETNLLKNQILDKERLIKNLVIELAKNTGSTASDYIVSQIESLNNEIS
                     ILKDKINILESSNINISSDSINIDIIVSNLKRFNDEVDNASLDDKRLLLSTIINSIVW
                     DSSLGNLNIVYMGAEVDNSVSLSN"
     gene            14774..14950
                     /locus_tag="KR257_001742"
     CDS             14774..14950
                     /locus_tag="KR257_001742"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435444.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0030446.1"
                     /translation="MEINVIEIFPKDKAKLNKIEMDKASWFVNIISKKYPKEALNEAF
                     STLEKELNISKANT"
     gene            15124..16254
                     /locus_tag="KR257_001743"
     CDS             15124..16254
                     /locus_tag="KR257_001743"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003462216.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="iron-containing alcohol dehydrogenase"
                     /protein_id="HBH0030447.1"
                     /translation="MNNFEIKTRIKFGEGSLKALQELKNKNVLIITDPFMVKSKTIDK
                     ITSNLINSTYQVFEEIVPDPPIEVVVAGIEAFKSINPDVIIALGGGSAIDAAKSIMDF
                     SKKILKINEVEFIAIPTTSGTGSEVTSFAVITDSQKKCKYPLVSDDLLPDMAILDPEL
                     VKTVPNFITADTGMDVLTHAIEAYVSTNSNDFSDALAEKAIKLVFKYLIKAYKDGNDI
                     EAREKMHNASCLAGMAFNQASLGINHSIAHVLGGKFHIPHGRTNSILLPHVIEYNSSI
                     VGYTNTTYSATAKKYAQIAELVGLGSANIRISVRNLVNEIKKLQKEMNMPTKLTQCKL
                     SLEDITNEEREIAKLAIKDTCTLTNPKVPTEDDIINILKNIK"
     gene            16495..16845
                     /locus_tag="KR257_001744"
     CDS             16495..16845
                     /locus_tag="KR257_001744"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003453843.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="BMC domain-containing protein"
                     /protein_id="HBH0030448.1"
                     /translation="MTEESKQRVIQEYVPGKQVTLAHIIANPNEDIYKKLGLVLDKKD
                     AIGILTITPSEASIIAADVATKASNVSLGFIDRFSGSVVISGDVSSVESALNDVLEVL
                     GNMLNFSSTKITRT"
     gene            16853..17302
                     /locus_tag="KR257_001745"
     CDS             16853..17302
                     /locus_tag="KR257_001745"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423975.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="EutP/PduV family microcompartment system
                     protein"
                     /protein_id="HBH0030449.1"
                     /translation="MKNIIFMGKTGSGKTTLCQKLDQLELKYKKTQSVELYNNAIDTP
                     GEYMENRNLYNALITTSADAKIIAIVYDATQEENYIAPGFASMFCKDVIGIITKINKA
                     TENEVNIAYERLSLAGASQIFKIDTVDNIGLEKLFKYLEKYKNIDEV"
     gene            17404..17979
                     /locus_tag="KR257_001746"
     CDS             17404..17979
                     /locus_tag="KR257_001746"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428683.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator"
                     /protein_id="HBH0030450.1"
                     /translation="MGKKILLVDDEPLLRMDTKDILESHGYEIIGEASDGFEAVEMCK
                     KHKPDLVIMDIEMPILDGIKAGKIICKENIAGGVLLLTSFEDKEYVEKAKSIGAYGYL
                     VKTASEKSLIPTIEMCLNKVNEFEKMKKDLEKVNSKLNERKLVERAKGILIREFKISE
                     DEAYTRIRKLSMDKRTTMMEIAKMIIIGYDD"
     gene            17972..19381
                     /locus_tag="KR257_001747"
     CDS             17972..19381
                     /locus_tag="KR257_001747"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423979.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="histidine kinase N-terminal domain-containing
                     protein"
                     /protein_id="HBH0030451.1"
                     /translation="MTNTIKKISTAQTYLNNNEIEKIIEVSKSLDLMASFYEADVFID
                     VLSKFDDEAIVVAHGRPKEKSMYCENVIGKKALIENEPGVIKCLKTGERVRDIKALTQ
                     EYKLVKQNIQPITLDDKVLAVLIVEKDISSEVKNEFNASEDEENKNLHQFIKLIGNND
                     FLVDNLNSAILIFDKNGKLKIKNRIATEIYKNLGFGYDIQDMHYNDLDIETNTFENIL
                     MDENYDETNEVSIGNMFFKIKTIYIKDDEFKVCKIVQDISDLKRKEEELVLKTVAIRE
                     AHHRVKNNLHTVISIIKKQSRLSQNDEVKQCLDNIINRVFAILSTHYLLSKEVDNNIS
                     IREGINLLVSNIQGGYLFSKDIDIRITGEDFKISGEKATAILLVINEILQNCYDHAFS
                     DREHGTIQILINKDNDYRNIAIIDDGIGFDSNNINKNSLGTYIIDSYITQMLKGNIER
                     KSSENGTEVLITIPTQINI"
     gene            19565..20998
                     /gene="eutA"
                     /locus_tag="KR257_001748"
     CDS             19565..20998
                     /gene="eutA"
                     /locus_tag="KR257_001748"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004458698.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ethanolamine ammonia-lyase reactivating factor
                     EutA"
                     /protein_id="HBH0030452.1"
                     /translation="MREELLSVGIDIGTSTTQLIFSKLIVENTESNFSVPRISIVDKE
                     IIYKSKVYFTPLISNNEINGQQIKDIVENEYKKANISKEDIHTGAVIITGETARKENA
                     NDVLHTLSGFAGDFVVATAGPDLESIISGKGAGAHIYSKEHSTTIVNIDIGGGTSNIA
                     SFKRGEVTDTGCLDIGGRLVKIDKISKKITYISPKIDKIIKDNNLNLQVGTMATVENT
                     KPIVDIMVDLLMESIGLKKQTPLFDFIITNKSISIDENIKNVSFSGGVADYIYYDGEI
                     KDYFEYGDLGILLGQAIKNCEYLKKVNVVKSMETIRATVVGAGSHTTEVSGSTITYTS
                     EKFPLKNLPVLKLSIDEETGTSKQISEAIKNKLNWFKLENDLQKVAIAMIGKKNPTFL
                     DIQEYAKGFVDGMQQIIENDLPFIVIVENDMAKVLGQAIYALLNYEKEIVCIDSVKVE
                     NGDYIDIGKPIVEGKVLPVVIKTLVFN"
     gene            21016..22380
                     /locus_tag="KR257_001749"
     CDS             21016..22380
                     /locus_tag="KR257_001749"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003454054.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ethanolamine ammonia-lyase subunit EutB"
                     /protein_id="HBH0030453.1"
                     /translation="MILNTKLFGRTYQFKGLYDVMAKANEEKSGDKLAGLAAESAEER
                     IAAKVVLSHIKLEDIRNNPAVAYEEDEVTRIIQDAVNEKVYEEIKNWTVSELREWLLD
                     SNTTSLDIRRISRGLTSEMIAAVAKLMSNMDLVYAAKKIKVTAHCNTTIGEQGTLSAR
                     LQPNHPTDDPDGILASLLEGLTFGIGDAVLGLNPVDDSVESVTKVLKRFEEVKQKYQI
                     PTQTCVLAHVTTQMEAIRNGAPADLIFQSIAGSEKGNEAFGFNGDTIEEARQLALKHG
                     TATGPNVMYFETGQGSELSSEAHHGIDQVTMEARCYGFAKKYEPFLVNTVVGFIGPEY
                     LYDAREVVRAGLEDHFMGKLHGLPMGVDVCYTNHMKADQNDMENLAILLTTAGCTYFM
                     GIPHGDDVMLNYQTTGYHETASLREMFGLTAIKEFDAWMEKMGFSKDGKLTELAGDAS
                     VLLG"
     gene            22393..23274
                     /gene="eutC"
                     /locus_tag="KR257_001750"
     CDS             22393..23274
                     /gene="eutC"
                     /locus_tag="KR257_001750"
                     /EC_number="4.3.1.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014952556.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ethanolamine ammonia-lyase subunit EutC"
                     /protein_id="HBH0030454.1"
                     /translation="MNEKDLKALVEQLVGQMLGELDTNVVSETVKKATEVVVDNNACI
                     DDITEVDIRKQLLVKNPKDAEAYLDMKAKTPARLGIGRAGTRYKTETVLRFRADHAAA
                     QDAVFSYVDEEFIKENNMFAVETLCKDKDEYLTRPDLGRKFSPETINNIKSKFGTNQK
                     VLILVGDGLSSAAIEANLKDCVPAIKQGLKMYGIDSSEILFVKHCRVGAMDHLGEELG
                     CEVICMLVGERPGLVTAESMSAYIAYKPYIGMAEAKRTVISNIHKGGTTAVEAGAHIA
                     ELIKTMLDKKASGIDLK"
     gene            23294..23947
                     /gene="eutL"
                     /locus_tag="KR257_001751"
     CDS             23294..23947
                     /gene="eutL"
                     /locus_tag="KR257_001751"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003761789.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ethanolamine utilization microcompartment
                     protein EutL"
                     /protein_id="HBH0030455.1"
                     /translation="MKNDVIRPNILGIKIISNISPEMAQKLELKSHHKSLGLITADCD
                     DVTYTALDEATKASEVDVVYAKSMYAGAANASTKLAGEVLGIIAGPSPAEVRSGLNAV
                     VDFLEYGATFISANDDDSIAYYAHCVSRTGTYLSEVAGIREGEALAYLVAPPLEAMYA
                     LDAAMKAADVKMCELFAPPTETNFGGALLTGSQSACKAACDAFAEAVKSVADNPTGF"
     gene            23958..24659
                     /locus_tag="KR257_001752"
     CDS             23958..24659
                     /locus_tag="KR257_001752"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428690.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="BMC domain-containing protein"
                     /protein_id="HBH0030456.1"
                     /translation="MDAIGLIEVIGYVAAIEASDACLKSANVNIVRVDKVGAGIVTLT
                     ICGDVGAVKAALEAGEIAASRVGTLRTSHIIPRIHNEVTNALFKTKEPKVCEVSEDKE
                     KNFEITLEIADNVSKNLSEKENVILDVNENSGDTENLYSDIDKTNKKIETVDDSLTEA
                     NEEKIENTNDKEVLEQVKIENSDFDRDDLSKNSVKKLKAMAKKLDSSITYKDLNVLKK
                     EELINLVKKLSRRDR"
     gene            24662..26131
                     /locus_tag="KR257_001753"
     CDS             24662..26131
                     /locus_tag="KR257_001753"
                     /EC_number="1.2.1.10"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889875.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="acetaldehyde dehydrogenase (acetylating)"
                     /protein_id="HBH0030457.1"
                     /translation="MTLLDKDLVSIQEVRTLVRRSKVAQEKLSKMSQEQIDKIVKAVV
                     DAAFNNATKLAKMANEETGFGKWEDKVIKNTFASMGVYETLKNTKTIGIIGEDKEANT
                     IDIATPVGVVAGLIPSTNPTSTVIYKTIISLKAGNTIVFSPHPNAKNCILETVNIISE
                     AAIKAGAPEDSILCITNPSIVGTNELMKHKDTNLILATGGEAMVRAAYSSGTPAIGVG
                     PGNGPAFIDKSANVKLAIKRIIDSKTFDNGVICASEQSIVIEKSMEETVLKELKNQGA
                     YVLNEEESERLAKFILRANGTMNPQIVGKSVEVIANLADLTNVPKNTKVLVARENKVG
                     HNVAYSREKLTPILAFYVEENVEAIMNRCREILLNEGAGHTFSMHVNDEELVKRFALN
                     MPVSRILVNTPSALGGIGASTNLVPALTLGCGAIGGSSTSNNIGPLDLINVKRVAYGI
                     KEIEELGRDKSQVEKSMFDSMDKEELINLLVQKLVKELA"
     gene            26227..26514
                     /locus_tag="KR257_001754"
     CDS             26227..26514
                     /locus_tag="KR257_001754"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_464705.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="BMC domain-containing protein"
                     /protein_id="HBH0030458.1"
                     /translation="MASANALGMIETKGLVGAIEAADAMVKAANVQLVGKEQVGGGLV
                     TVMVRGDVGAVKAATDAGATAAERVGELISVHVIPRPHFEVDAILPKVSAE"
     gene            26641..27402
                     /locus_tag="KR257_001755"
     CDS             26641..27402
                     /locus_tag="KR257_001755"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729043.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cobalamin adenosyltransferase"
                     /protein_id="HBH0030459.1"
                     /translation="MGVLTENEVKRKIGKNKNNITEFYIEKGQIITPSAKSYLAERSI
                     ELKYVDKLSDVNNEPKEVVKEVVKEKKYKYTTVFGAKLDEKPEHMTQLNGNLLVFKDH
                     KRIILRGKIDSLESEILKVQILCQKLDMPKLVKELQEVLDFVRNIMRCEVLDEKLGDF
                     KLLGLTPQELREQSHYPKKYFGIGHEFPSYEMGEVVVAINSIRSNTREVELAAYEAFK
                     GEYGNVHREDLIKALNRLSSVFWIMIYKVRTNKYK"
     gene            27415..28044
                     /locus_tag="KR257_001756"
     CDS             27415..28044
                     /locus_tag="KR257_001756"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902845.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphate propanoyltransferase"
                     /protein_id="HBH0030460.1"
                     /translation="MENLLNEIVEEVITRVKKEAFIEVEASGRHVHLSREDVDKLFGE
                     GYTLTKLKDLSQPGQYACKERVTITGPKGSIKNVVVLGPCRNETQVEISLTDGSTLGL
                     KAPIKQSGDLEGTLSIKISTQYGEVELDKGLMVAKRHIHMTPKDAEKFNVCDKEIVEA
                     KVMGQRPLTFDDVVIRVSDSFKTYMHIDYDEANACGYSKGTVAKIIKKA"
     gene            28086..28811
                     /locus_tag="KR257_001757"
     CDS             28086..28811
                     /locus_tag="KR257_001757"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861392.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TIGR02536 family ethanolamine utilization
                     protein"
                     /protein_id="HBH0030461.1"
                     /translation="MNYDNLVDLITEEIYKKINSNEIKISNKPKAVIVFEQDNNKFNL
                     LKDGFEIVEFDKSIRECEIVIVSRLCMRGLSNIALGNSTSDEERFILKMIMNGKKVYV
                     LDEGIEYKKYKDTAPKALYKKFMSFEDEICKFGVEIIKDLNVITKNKLNIKKELESTR
                     GSKKEDTKVLDKDILNLTSVESVKIDNEFSLDLRNKKLISEADLRKPTINGVKNILVN
                     KKSIITPLAVDFMRIHHLKLKKL"
     gene            28824..29096
                     /locus_tag="KR257_001758"
     CDS             28824..29096
                     /locus_tag="KR257_001758"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435411.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="EutN/CcmL family microcompartment protein"
                     /protein_id="HBH0030462.1"
                     /translation="MDIGKVVGNVWATRKDEKLCGQKLLVVKILKTKDTYKEGFMVAA
                     DNAGAGNGDLVLISKGSSARESIEKSHVPVDATIVGVVDSFEVFDE"
     gene            29089..29640
                     /locus_tag="KR257_001759"
     CDS             29089..29640
                     /locus_tag="KR257_001759"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729042.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="BMC domain-containing protein"
                     /protein_id="HBH0030463.1"
                     /translation="MNKSIGAIEFKSIAKGIEVSNEMIKKSSVDVLYLKSICPGKFLI
                     IVGGETSYINECVDYGIKLGEGYIVDNFVINAISQEILDGFKNKYQKLDSIVSIGVVE
                     SSKICAGIKMLDKTLKSGDLVLVKLQLSFAIGGKLVYIVAGDLSSLEYALKESENVVR
                     EKEVIYKTVIPSVDSQIIKSLIK"
     gene            29652..30743
                     /gene="eutH"
                     /locus_tag="KR257_001760"
     CDS             29652..30743
                     /gene="eutH"
                     /locus_tag="KR257_001760"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889882.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ethanolamine utilization protein EutH"
                     /protein_id="HBH0030464.1"
                     /translation="MSINEIIIYVMVVFMVLGAIDKCIGNKFGLGEQFEEGIMAMGSL
                     AVAMVGVICLAPVLADVLRPIVVPVFNILGADPAMFAGSLLANDMGGAPLALELAKDP
                     NAGLFGGLIVGAMMGPTIVFIIPVALGIIEKEDQKFLATGILAGIITIPIGAFVGGLV
                     AGFEVMMVLRNLVPIIIFAVVIALGLLKFENAMIKGFTYFGKGVVIVITLGLAAAIVE
                     ALTGIVVIPGMKPISEGIEIVGDIAIVLAGAFPLVFVITKVFNKPLMALGKVLGMNDV
                     SAAGLVASLANCIPMFGMMKDMDNRGKIINVAFSVSAAFVFGDHLGFTAGFNSNMITP
                     MIVAKLVGGITAVLLAMVIANKTLKKENV"
     gene            30745..31218
                     /locus_tag="KR257_001761"
     CDS             30745..31218
                     /locus_tag="KR257_001761"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893336.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF861 domain-containing protein"
                     /protein_id="HBH0030465.1"
                     /translation="MDISNIDKNLIETLVRQIIEEKISGTKDTVDFVRNKDISGITSI
                     KLPTVKVSESDRLDTGNPSDVVYTKDLFTLEESPRLGCGMMEMKETTFDWTLNYDEID
                     YVIDGTLDIIIDGRKVSASSGELIFIPKGSKIQFSVPDYARFIYVTYPADWASQN"
     gene            31731..32252
                     /locus_tag="KR257_001762"
     CDS             31731..32252
                     /locus_tag="KR257_001762"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889887.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MarR family transcriptional regulator"
                     /protein_id="HBH0030466.1"
                     /translation="MEEIVKKEQASMNDIFLYLKAKSNSLYKFVILYNEFINKPKDYG
                     TGELINMVEVHMLTAIEENPGISPTQLAKIWNRTKGAISQTISKLEKKGYITKEKKEG
                     NAKTILLYPTTSGVELSKAHKLYDTIDVTRTFEYLIKECTLEEIDSFYKVIDLFINLL
                     EESPQENNDSEKV"
     gene            32631..33794
                     /locus_tag="KR257_001763"
     CDS             32631..33794
                     /locus_tag="KR257_001763"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889888.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amidohydrolase"
                     /protein_id="HBH0030467.1"
                     /translation="MNLKQLSEKYEEYVIQMRREFHKYPELSFKEIRTTQRIREELQK
                     IGVPFVSIEPNIVIATIQGKNEGKTIAIRGDIDALPMQEDSDVEYKSEYDGIMHSCGH
                     DAHGAMLLGLAHMLNDIRKDLKGRVLLVFQAAEEVGGGHKEIIQYFKENGGPDRLIAT
                     HVWSDIEAGKISVEPGPRMAGGSGWRIDITGRGGPDQSIDPIKPACDIVLKVSSIPVN
                     HISVLEQCVVHACAIHGGTTIGNVIPNNAEVIGGYRYFTEESGKKVFDIIKQMSNGVG
                     QVYGVDVKVTHTGGIGPVINDEEAVKMAKEIVSNIDGLELDSYEPICASDCYGEILKE
                     YSGFYCYLGVGNKEKGIIYAQHHPKYNIDEDILKLGCEFMAKYAVEFLNKNNN"
     gene            33828..35366
                     /locus_tag="KR257_001764"
     CDS             33828..35366
                     /locus_tag="KR257_001764"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889889.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AbgT family transporter"
                     /protein_id="HBH0030468.1"
                     /translation="MQGALKENKKKSGGGFLGWIEKVGNKMPHPLALFTYITLIVVAL
                     SAIASFLGFSATSPATGKLIKVMNLISAKGLVLFMQEFVKNFQNFPVLGVVLVMAVAT
                     GVCEKTGFFSTAIKMSLSKVKGNAVVFIIAFIGVFANQAGDAAFVLVPTLAGAIFYGL
                     NRNPLAGIFCGFASVGGGFATAVIPGGWDVTLTPITVSAAQTIQPAFDMTLLASYYAL
                     FVSAFIVATVSTIVTVKFIEPKLGKYTGKPEGIDDNQGFEVTKEQAKAAKLAGFTVLA
                     YVALLIALCIPANSFLRSPEGSLIFGAPLMSCLQFFIVILFFLPGIVYGMRVGKIKTV
                     KDLNDILCQSMAAMAPFIVLAIVIGQFLTLFSVSNLAQVLAIKGGALLNSLPLPPQAI
                     ILLFLVLVAFINIFVISGSTKWMIFGPVFVPMLMQLNIHPAFTQFVYRLGDSVTNHLS
                     PLNAFFIILLATVQKYDKNAGMGTIFSAMIPYTIGYFVVLAVLVVVWMTIGIPVGIGG
                     QVWL"
     gene            35398..36600
                     /locus_tag="KR257_001765"
     CDS             35398..36600
                     /locus_tag="KR257_001765"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889890.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pyridoxal phosphate-dependent aminotransferase"
                     /protein_id="HBH0030469.1"
                     /translation="METTEIRYNFDEVIDRSGTNCLKYDLKSQFMPESPEDALPLWVA
                     DMDFACAPEIINAMHERIDRKIFGYSSQQTDDYYEAVCGWFKRRFDWKIEKENIFFSP
                     GVVPALGFFTQILTQKGDGIIIEKPVYYPFEDKITNNERKVVNSPLKFEDGHYSMDYD
                     GFEELAKDENNKVFILCSPHNPVGRVWKKEELRKIVDICKKYDLWIISDEIHCDIIRK
                     GEKHIPLEVACPDYKDRIITCTAPSKSFNLAGMQLSNIVINNKELQEKWMLETDSKLA
                     IFLPNPFAIVATKVAYNDCEDWMNQVNEYIDGNIKYVEDFVNEYMPKVKIIKSQGTYL
                     VWLDFRGYGLDAKQLEYVMLNKAKVLLDEGYIFGEEGAGFERINVASPRTIIEECMNR
                     IKCAFEGL"
     gene            complement(36767..37366)
                     /locus_tag="KR257_001766"
     CDS             complement(36767..37366)
                     /locus_tag="KR257_001766"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435382.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="HBH0030470.1"
                     /translation="MNDNIVEVKNINMNFYTKEGELEVLKDVNFNLKEGEILTLLGPS
                     GSGKSTILNILTNLLKPTSGDIKITGNIGYMFQKDNLLEWRNIMDNITIGLEIQGKKD
                     KKSLDRVESLLKTYGLWDFRSMYPKELSGGMRQRVALIRTLSVNPDILLLDEPFSALD
                     YQTRLLVCDDVYSIIKNENKSTILVTHDIGEARCIKVQL"
     gene            37536..38894
                     /locus_tag="KR257_001767"
     CDS             37536..38894
                     /locus_tag="KR257_001767"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729040.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0030471.1"
                     /translation="MSNIITNLIESIFTNPITILFLLAITVYSVFKIIENNRVYSFVS
                     SKLDEINRDYKTSEFYKKVRDDYYTYSKENPYADVNITSFIEEVVSDLKHNNLPLLEK
                     IRSIKNSSSISILLGVLGTFVGLSTMLLCVDTKDIINSLPSTISSMQTAFTTSIFGVV
                     FSLIIGYFTKIKDCEHVLIQIMLKSENLLTSEITHFKSERMDLKVEEVKNTIKQISKS
                     IEAIEKFDKISKDLNDFNDEFISGIEALKSLLEGSQSSIKTFDQSVRKLDKQFNILNI
                     KFVKLFDKYDNQDNINKEILFDIKESSKNIYNATESQFKIRDYIKNINAGFALYERSA
                     QDLLTKLMTHENKISQNQKILLDEKFTLDDSIKNLSSIIENFSNDLQVKLDMMFENSL
                     DIQDKLDVMFNNSFMNDEVPLDSEELFKDDVNNVFNPFSEEIYEIEDKEIKVIGEDEL
                     NE"
     gene            38887..39519
                     /locus_tag="KR257_001768"
     CDS             38887..39519
                     /locus_tag="KR257_001768"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424014.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="OmpA family protein"
                     /protein_id="HBH0030472.1"
                     /translation="MNNKYRRTVNREFEKSSFWPTFTDLLSTVLMVVILILFSSESIS
                     GSVEQDLAKNVNASVEETFKKSGIPVKVDKSNGQVTFGEKTMFDVDSDVLKPEAKEML
                     KMFVPKYIETIYKDYGDYISKIVIEGHTDDVGSYIYNLDLSQRRAYSVAKFIVGDEIG
                     DYKYKDKVTKHIIAIGRSKAELIKNGDNSVNRDASRRVELKYEININQNK"
     gene            39848..41005
                     /locus_tag="KR257_001769"
     CDS             39848..41005
                     /locus_tag="KR257_001769"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435380.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MBL fold metallo-hydrolase"
                     /protein_id="HBH0030473.1"
                     /translation="MIEISIKNKKNSKIKTLILLLIVSISIYLTGCTTLDNGNNQSNN
                     NDSLSSSISSDKNVKIHFIDTGNSDAILIQDGKTFILIDGGDNDDEGLMVDYLNNQGV
                     KDIKYLIATHSHADHLGGLDSVVKNFNIENVFVSNGSAETKSYRDFINALANKGLSPS
                     VPLENNKFYLEDSYFEVLNTNGGDTTNEQSLVLVYTNGNDKVLFTGDAEEGTEKEILP
                     KLEKVDLLKVAHHGSRSSSSQEFLDKVNPEYAVLLVGKGNSYGHPHQETMNKLKKMGV
                     KVHRSDECSDIIFESTGDGVFTSCKDGSYNKGVREDGNSGKSNSNTSKNDSFKNKQNT
                     SNSEEIVYFTPKGKSYHSTKNCSGLSRSKKILSGTIAESKKNDPCDICYGK"
     gene            complement(41152..41787)
                     /gene="lexA"
                     /locus_tag="KR257_001770"
     CDS             complement(41152..41787)
                     /gene="lexA"
                     /locus_tag="KR257_001770"
                     /EC_number="3.4.21.88"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897067.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcriptional repressor LexA"
                     /protein_id="HBH0030474.1"
                     /translation="MYLDLTEKQVLILEFIKSQIILKGYPPAVREICTAVGLRSTSTV
                     HSHLNKLEKLGYIRKDPTKPRAIEVLERSKVNDVSGANQEIIELPLVGQITAGEPILA
                     QQNIEEYIPFPASLVKGSNNFVLRVKGESMINAGILDEDYVVVDKKNTALNSQIVVAL
                     INGESATVKRFFKEGNLIRLQPENDFMEPIMLNDSEVEIVGIVTGVFRVIK"
     gene            complement(41868..42995)
                     /locus_tag="KR257_001771"
     CDS             complement(41868..42995)
                     /locus_tag="KR257_001771"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435347.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tyrosine-type recombinase/integrase"
                     /protein_id="HBH0030475.1"
                     /translation="MNNDKKIIKVHNKSDKPDNIVIKENELIEKCLLLENKLPVFMKD
                     YFIYLKGSVAVSTRLAYLEDINFFCSYLIETKELTNADCVKDITEDDFNTIKSRDINL
                     FLGDYCSRYYKNTEKNTLIFENNNRALARKKSSISTLFKFLYRNSQIDNNITDGFNPI
                     KLPKPQPDAIKRLEIDEVAKMLESVETGEGLTEKEKVYWRKTKLRDKAILALFVTYGL
                     RLNELRELNISSFNFSRGEFKIYRKRGKEVLMPINHTCEHVIKDYLQNERTRDELLND
                     EEKDALFLSLQNKRITAKAIRTLVKKYTSIPLDTTRDNGYSPHKLRATAATSLIQTGF
                     SIYDVQNLLDHDNVTTTQLYAAHKKNVKRDIVKNFEWIEDD"
BASE COUNT        16333 a         5699 c         7730 g        13562 t
ORIGIN      
        1 atcagcggtt atctaacaaa gaaattgcag gacttgaatg ttgatactat tagaaccgat
       61 atactgacta gccccacagt tacagatgta attgtgtgga atatcgaaca gtcgggaacg
      121 gacacttttt ctgctaccta cgaagtagat cagcagataa aagagggaga acagacaaca
      181 acagtcaagg caacctatac ggtaaaagtc catgtagacg ctgacaggga tatggtaatt
      241 attcagaacc ctacccttgc accagcaatc gaaaaatcgg actatgagcc aaagacacca
      301 gaagcagacg caagtgtaga cgctgatacc gtgaatgacg ctaccgcatt tctggaaaca
      361 ttctttaagc tgtacccgac agccacagca aaagagcttg cctattatgt atttggaaat
      421 gtgcttgaac ctatcggcag ggactacctt tattcagaat tggtaaaccc agtacttaca
      481 aaggacgggg ataatatgaa agtcaaggta gctgtaaaat tccttgataa tcagacaaag
      541 gcgacgcagg tattgcagta tgagcttatt ctacataagg atagtaactg gaaaattatt
      601 atgtaagaca ttttgttggc aggatctatt ttcggatata gtctgccttt tctgtagcaa
      661 atgtactgca ctgacaagct atttcattgt attttaagca attaaacctt tcttgacaat
      721 tttatcttaa atcatatatt tatggatatt gactttctgc ttgcaataag ctataatatg
      781 actataaaat caaatcagtc atataggagg tatgtggtat gtataaagaa gttggtattt
      841 cttcaaataa tgttccgata acactttcta tctggtatac agaaagaagt agtcctacca
      901 ttgttttttt gccgggtact atgtcacacc ctctcatgta tgagaatttt ctatgtggtt
      961 tgagtgaaag aggatttaat ataataggca ttcactatct ttcacacgga aaaagcccta
     1021 aaatcaaaaa aaattataca atggaagatt tgctgcataa tgtatatgac gcaacaactt
     1081 acggaataga aaatttcggt gaaaacatag ctgtcatggg ttccagtcaa ggcgggattt
     1141 tagctgcaat ggcggcaggt agggacacaa ggttaaaagc cgtttttcca cataatatca
     1201 tgctgaccac attaaaagaa actatgagct taacaaaata tcccacatgg tcgcaccgtt
     1261 ttatggggct gatacagtgg ggctttcgtg taggtggaaa attgctgcct aactacaagg
     1321 ttccaggaga cgcttattta gactatgaca gagtatttta tagtgaacag gcaaaacaag
     1381 attgcttaaa tgaccctatg cttttaccct attatccttt aagatttgtc accagcttat
     1441 ttaatgctga cttatcgtgc ctggagaatg gggctataca atgtcctgtt attttaatta
     1501 ctgccaaagg cgacccgctt tttagctttg attataccaa caaagtattt gatttaattc
     1561 atgtaccgca aaaggaatta cttgctttag agcttaatcg tcacatgatt tttaatgagg
     1621 acacggacac tacaataaac gcattggaag ctaccttgca taaatatctt ggatagcata
     1681 ttgattatat aatcagtaaa tgttatactt ttcatgacga tataaatatt ttagtcataa
     1741 ggaggttatg agtttgccac gatttacgga acaagaaaaa gaaatcataa acagtaaact
     1801 tttgatagag ggagaaaagc tgtttgcatt acacggctta aaaaaagtaa cagttgatga
     1861 tttagtagct gctgtaaaca tatcaaaagg ttctttctat gctttttatc ccagtaaaga
     1921 acatctatat gttgaaatca attttcgctt acaaaaagag ttatttacaa gtatagaaac
     1981 aaccattaaa aagaaaaagt ataagaacca tagagattta gcaaaggacg ttatcatgct
     2041 aagtttaacg ggggtgatta cttcgcctat tctttcacag attgatttat ctttaatgga
     2101 ctatctgcaa agaaaaatat cgtcagatat ttttgaaaat catatgtaca gtgatattcg
     2161 tatattggag atattggaag atttaggggt tgtatttttg gttccgcata cggttattat
     2221 aaaatccctg tattctgtct tatcctgttt ggaacaattc aaagaggacg aagaactgaa
     2281 tatgatacaa aatcttttag tgaatggtat tattcagcaa gtagtagcag agtaacaatt
     2341 ttgtttggtt atttgacagg caggtagcca aacaaatttt ttacagttta tatgactata
     2401 tatctataaa cgtcataaag ttaaaggagg aatgaataat gattgatgta aaaaaactgt
     2461 attttagcta tactgacaaa ccgtttgtgg agaatgtaag tttccatgtt gggagaggag
     2521 aaatttttgg ttttttagga ccctctggtg ctggaaaatc aactattcaa aaagttttaa
     2581 ctgggcttaa tacaagatat aaaggcagtg taaaagttgc aggtacagaa ataagggagc
     2641 atacaaatca gttttatgaa aatattgggg tagactttga attttcaacc tgctacgaga
     2701 aattcacagc acgacaaaat ctcgcctatt ttgcttctct atatgaaaag caacctcggt
     2761 ctattgatga attattgcat atggtaggct tggaaaatga cggggacaaa aaagttgctg
     2821 acttttccaa aggtatgcgt tctcgcttga atttcattaa agcgttagtc catgaccctg
     2881 atatattatt ccttgatgaa cctacaagcg gtcttgaccc tacaaatagt cgtttaatga
     2941 aagatattat tcttgcggaa aagaaacgcg gaaaaacgat tatcattact actcacaata
     3001 tgtttgacgc aacagagcta tgtgaccaag tagcctttat cgttgccgga aaagtcagtg
     3061 cattggatag cccgcataat ttgattatgt caaggggagc tgccaaaata caatatacct
     3121 actatgataa aggcgagaaa accggagaat gtctgcttga tagaaccaca gaagataagt
     3181 tgttaaaaag tttaatttcc gaaaaccgtt tgctttctat tcatagtagt gagcctacat
     3241 taaatgatat ttttgttgat attacaggga ggacacttca atgagattgg gacgtttaat
     3301 ttgtggtgat atacatttcc aatggaaata tggtttctat tttatctact ttatattaac
     3361 agttttatat gtgtgcggga ttgccgcttt gccggaacat tggaaaacgg atattgcttc
     3421 tattatgatc tactctgacc cggcagcaat gggattattt tttatgggag cgattgtcct
     3481 cttagaaaaa agtcaaaagg tgttaaatgc tatggtggta tcccctgtaa aaatatcgga
     3541 atatatactt tcaaaaacag ttgcgttgat tgctatttct acggtaatcg cattgatatt
     3601 aggggtagtt tccggcagca atcatttact gggtatcgca gttggtacgg ctttgacctc
     3661 agcaatcttt actatgcttg gaattattgc agctacaaaa atttcaaact tgaaccaatt
     3721 tctcattgtg attatgccga tagaaattat ttgctttgta ccacctattg ttggtctgtt
     3781 tgtgaagtta ccatatctgt tccgcttttt tccattcaca gcttgcatga accttataac
     3841 tggaaaaagt gttttactat cgtttgatat ggtacttgta attgctacgt tgattatcct
     3901 ctacatagtt gctcgacata cagttgagca tatgtggaaa agtttgggag gtgtaaagct
     3961 atgaaaaaga tattatccag caccatacag atatttaagc aaatcaaaag tgaccctatg
     4021 atgtttgcgg cttgcttctc cccttttatt atggggactt taattaagtt tggtattcca
     4081 tttcttgaaa gaataacgaa gttttcttta caagcgtatt atccgatttt tgatttatta
     4141 ctttctatca tggctcctgt attgctctgc tttgcatttg caatgattac attggaggaa
     4201 atcgacgata aagtgtcacg gtacttttcg attacccctc ttggtaagtc ggggtatctc
     4261 tttacaaggt tgggagtacc ctcaattatt tcggcggtca tcgcttttat tgtactgtta
     4321 cttttttcat tagaaaagtt gtccattgga atgacaatat gtttggcgct tctcggctca
     4381 gtacaggcaa ttattgtttc acttatgatt atcacattat caagcaataa attagagggt
     4441 atggcagtta caaaactagc tgcacttaca ttgctcggaa taccagcccc cttttttatt
     4501 gatagttact accagttcgc ggttggcttc cttccatcat tttgggtagc gaaagccatg
     4561 cagaatgaag cggttcttta tttctccata ggattggtgg tagctttagt ctggtactac
     4621 ttccttacaa aacgtctgtt tcggaagctg gcaggataag gaggcatatt atggaaaaag
     4681 gtagacttct gcaaaacaaa aatatgaata aggctattca ggtttccaaa attacactaa
     4741 tcatcaatct gagtttatcg ctacttaaat ttgctgccgg atatatagga aagtcaagtg
     4801 ccatgctgtc ggacgctgta cattcggctt ctgatgtagt aagcacaatc gttgtgatgg
     4861 ttggaattaa aatatcagaa aaacagcctg atagagaaca tccttatggg catgaacgta
     4921 tggaatgtgt ggcttccatt attctctctg ttgcattggc tataacgggt gctggaatag
     4981 gatattcagg tatcaagaaa atcttttcag gacagtacaa tacgctttct gtccctagtg
     5041 gaatcgcact tacggcagca gtcttatcta ttgttataaa agagtggatg tactggttta
     5101 caagaagtgc tgcaaagcat acaaattctg acgcacttat ggctgacgca tggcaccacc
     5161 gctctgatgc actctcgtcg gttggttcct taattggcat tttaggagcg cgtttaggct
     5221 atgctattct cgatcctatt gcaagcgttg tgatttgcgg ttgtatctta aaagctgctt
     5281 tgaacatttt caaagaaagc attaacaaaa tggtagacca tagttgtgac aatgctactg
     5341 aaacaaggat tagggaagtt gtgcttcagc agcaaggggt tgatggtatt gatgaattaa
     5401 aaacccgcat gtttggagcg aaaatgtatg tagatattga aatattagct gatggtaatt
     5461 tagctcttta tgacgctcat agaattgctg agggagtcca tcaaacgatt gaaaacaact
     5521 ttccacaatg taagcattgt atggtacatg ttaatacgaa tgaacttctc tattctgcat
     5581 aggacaggga agatgattta aggctattga aagggaaagg agggaagtag gttatggaac
     5641 aatactggtg gattatcatt gttgtggttt tgattgtcgt tggcttactt aaaattgtaa
     5701 ttatgaagaa gtataaccaa aggagaaatt ctaacaatcg ttcaaaagat agcgaggacg
     5761 acaagatgta ttaaggttta ttgaaatctg ttatgttgta gaatgatgtt tttagatact
     5821 agaaagtgct ttaagggggg ctaacgttaa ggaaagcttt gagtacaatt ctttacaatc
     5881 aacagtcttt tgcatagaga aatgtatgta ggaaatatgg tgcaaggcac aaaacaccag
     5941 caattgagaa atcaacctat gaaccaaagg cacactacat tttatactac ttgacaagta
     6001 aacgaacatt tactttaatg gtttaaagaa gtaaacgttc gtttactaaa gaaggaggtt
     6061 gtaaatgtct gacacaaaag aaaatatatt aaaaattgca ctacacttat ttgcagtgaa
     6121 tggttatgag gctgtttctg ttagtatgat tgcggaagcc ttgggaatga caaaaggagc
     6181 attatataaa cattataaaa ataagcaaga tatttttgac tgtatcgtag aacgtatgta
     6241 tcaaattgat aataagcgag ctaaggatta tcaagtacca gaaagcacaa tagaggtaac
     6301 cccaaatgca tacagaaata caactattgg aagtctaata acatttactc ttgcacaata
     6361 cgatttttgg gtgactgatg aatttgcgtc taattttcgc aaaatgttaa tactagagca
     6421 atatagaaat ttaaaaatga atatgcttta tcaaaaatgt cttgtaaatg gtcctatcag
     6481 ttatatagaa gatatattta atgaaatgat tgaaaaaggt gttcttcaag agtgtgatac
     6541 aaaacagctt gctattgaat attatgcgcc attatttcta ttgataagtg tagcagacgc
     6601 agttgaaaat tgttgggatt taaaaactca attaactaca cacgttaaac aatttgtcaa
     6661 gaaatatatt ataaatgaga aagtaaaata atcctttatt ctgtcctaaa tataaaccta
     6721 actttttaat ttcagcagag aaactcaaaa tgaatattgt tataagtcac aaatattaac
     6781 tattaaaata ttacaataac ggagatgaga aaatggaata tattcgcagt aaaaaatatt
     6841 ttacacccga cttacagaca aaaattatgg ggccgaatcc tataaaatta caagaggaac
     6901 tattacaaaa tcataaaatc ccgtctggta gctatgtctg tgaccttgga agtggacaag
     6961 gtttaacttc tgtatttctt gcaaaagaat atggatttgt tgtttttgca gttgacttat
     7021 ggagtgagcc aaaagaaaat gaagaatttt tcaaaaaaat gggattatct tctgcacaaa
     7081 ttaaatctgt aaaagctgac gccaatgaac ttaaatttga gaaagagttt tttgatgctg
     7141 tagtaagtac agattcatat aattattttg gacgtgaccc tatatattta gatgaaaaat
     7201 tgcttccatt tgttaagaaa ggtgggtttg tttatatcac agttcctggc atgaagaaag
     7261 attgccatga gaaacttcca gaagagttat tgttatcatg gacaccagaa gaacttgatt
     7321 atatacatga tataacatat tggtctaaca taattagtca ttgtaaaaag gcagatttaa
     7381 tttcaatata tgaaatggaa agtaattcgg aagtttggtc ggattggata aagcaaaata
     7441 atgaatatgc aataaatgac cgtaaggcaa tagaagctgg cggtggagat tatctgaatt
     7501 ttattgctat aattctacaa aaaaaataaa ttctttagaa ccaaacacta taatttgcgt
     7561 tctaatatgt ttaccgattg acatcaataa ttttatcttt gagggtaatg atttgaaaat
     7621 agaagaatac aagaagatac gaaattgata aattagaatt tgatgggatg gtgatattat
     7681 gaaaatatta tggatcatta ttattatggc agataatctg ctgccgttac tgcttgctcg
     7741 tttctatcca aactataagc ataaagaaat ggcactatct gtccttggct ctcgtcaaag
     7801 cccggtgaaa tggatatata atgtgtggtg cattatatca ggtgtggtat tttgtatcgc
     7861 tccatatgcg ttgtatcaag agaacgatag cggatgggca atcgctatat ggatgcttct
     7921 tgctatatac ggcatcgggt gtgaaatcat ttccggagtg tgcccgttaa atgaaaatag
     7981 acaagacgaa gatataatta caaaaattca cggcggcaca tcggcaatcg gatttatggc
     8041 cttgcttgtc gttcctttgc tctttgcaat tctgcaattc caaacaacaa aagtagtgtt
     8101 aggcgcaatt tcactggtgt gctttacaat agcattcata ttcttctgct tttttattat
     8161 gggtgagaag gaaaagtttg caaatactgt tttgagatat ggcggtcttt ggcaaaggct
     8221 tgttttaata agttgttata taccgttatt tgtttggtct gtttctaatc aataaaattt
     8281 agtttatagg aataacaaat tccagtttgt aaaagtcaat aaatccaaag ataaatttgt
     8341 atttgaaagg agttttgaag aatgaaaaaa tatgagtatg tagaaattaa ctataatgcg
     8401 aaaggagttg tattcctttg tactgataaa cacaaagaaa ttattgacag ttacgcaaaa
     8461 acggggtatc actacgcagg gtttgtaccc acagaaattg acgcaaaagg ctgtatgcga
     8521 aagatagatt taatttttga aaaagaagat taacttattt tagggagttg gttctaatga
     8581 taggacttaa aagacgagat atgaattata ttatgaaagt tggtgctaaa gctcaaggtg
     8641 tttctgtatc tgaatttagg gctatgctac aagataccat agacaaaact atggaaagta
     8701 cagacccaga cgtgcaggca aattttaaac gatactttgg aaataagcgc ccaacaccag
     8761 aggaatatat ttatacgatt accaaaaaga caaaggttaa ggtttaaatg ttgtaaaggg
     8821 ggcttgccgt atgaaacgct ttatgtacaa ttcagtatat tcaagcccaa tttaacagca
     8881 tactatttac aattaaatac gctataccag tagctcgtac aaaatttata ttttgtgcgg
     8941 gcttttttaa tacccgaaaa gtttttttaa ttattttcat ttttttggaa gcaaatcaca
     9001 ccttgctgta cagatatggt gcggaaagag ggataaacac ttttcaattc atagctggaa
     9061 aggaggtgag attatgaaac cgtctgactt ccaaaaaaca attcagtgtc agtttgaatg
     9121 taagctgaaa aaagttgtca aaggtattat ctggaactac cgtaaagaat taaaacgaag
     9181 aaaaaacaag gaaatatctt ttagcgaatt accagacatt acggtagaaa gtctggcaac
     9241 atgggacgac tacgaaacaa actacacaat ttttaatgtg tgtggcatag atattaaagt
     9301 ccttgatgat gaacttgcag aagctctcaa acagctaccc gaaaaaaaac gtaacaatgt
     9361 attgatgtat tacttcttgg aaatgagtga tacagagatt gcagatatta tgaattatac
     9421 cagaggggct gtgttcaaac acagacaccg tgcactagaa actatgaaag agatactaaa
     9481 ggagaagaaa tagaaatgaa gaaaaagtac aagcacccgt cttattattt gatttcatca
     9541 gctatggatg gggatgaaac tgcgattgag aaattactgg cattctatga cccgtacata
     9601 tcaaagtgtt gtttacgtcc tttatatgat gaatacggca atgtttatat tgttgttgat
     9661 atggaattaa agggacgtat tcgagaagcc ttaatcaaaa tgattttaga ctttgagatt
     9721 gatatagata tagaaaccga agaagaataa gcaaatacca gcagggcgtg attggttaaa
     9781 ttcccttctt tcctgccctg ctcctgcttt tatacatgga agcctacggc tttcgccgat
     9841 tgttctttga caactgaata aagcagacag atacgtttgt gatacagcga gccacgggga
     9901 ctgtacgcca tgacctttcc gacaagaaag cgagcgaccc acgcagttga tccgagagcg
     9961 acttgtggaa tggtcgtttt gccatgacct gctatcacag aataatgata cgtccgcatg
    10021 gtgcggttct gcccacaaga atgggaatag ttgagatact aacggagctt tccaaagccg
    10081 tctgtctgct tatgataaga cacacagaaa ggagttgttg caacatgaac aatactgatg
    10141 tgccgatttg ggaaaaatac acccttagta tagaagaagc gtcccgatat tttcgtatcg
    10201 gggaaaagaa gttgcgtaaa cttgccgagg aaaatctgga ctctggttgg gttatcgtta
    10261 atggaaaccg tattcagata aagcgaaaac agtttgaaaa aattattgat acactggacg
    10321 aaatctgatg tcttagagcc gtagatatgg tataatatta gtagcgtatc acggctcatt
    10381 ccatgacgga aaggagcttt acactatgtc aaaaatgaaa agacaagaca gtaaaggacg
    10441 caatttgcgt cttggagaga gccagagaaa agacggaaga tacgtttata aatataccga
    10501 tatattcggg aagccacagt ttgtatatgc ttggaaactt gtaccgacag acaaaacacc
    10561 tactggaaaa cgtgatgata aatcattgag ggaaaaagaa aagcagataa aaaaagacct
    10621 tgacgacggt atcgacacta tcggcggtaa aatgacagtc tgccagcttt atgcaaagaa
    10681 gaacaaccag aaaaagaaca tcaagagaaa cacggaaata ggacgacagt atcttatgaa
    10741 cgcactagaa aatgacccat taggtatgag ggcgattgat acagtcaaac agtccgacgc
    10801 taaagaatgg gctatcagaa tgaatgacaa aggttattcc tataagacaa tagataacta
    10861 taagcgttcc ttaaaggctt cattctatat ggcgatacaa gacgactgta tcagaaaaaa
    10921 tccttttcat ttcaagctaa gtgatgttct ggaagatgat acagagccta aagttatctt
    10981 gacaccagag caggaagaaa aacttctttc ctttatggaa acggataatg tttacagcaa
    11041 gtatcgtgat gaagttattc ttctgctgga aacgggactt cgtatctctg aattatgcgg
    11101 actgacaaca cacattgata tgcttaatcg tgtgattaac atagaccacc agctattacg
    11161 tgatacagag gtgggctact atatttccac acctaagaca aaaaacggca agcgagagct
    11221 tccattgaca gaaagagcat atcaggcact tgaacgaatt ttaaagaacc gaggaaaagc
    11281 tcaaccgctt gttgtagacg gttatagcaa tttcttgttc ttgaaccgtg agggcttgcc
    11341 aaaggtagca ggaaattatg aaagtatggt gcgtgggctg attaagaagt acaacaagac
    11401 ccatgaggac aagttgccga acatcacgcc ccactcattc agacatacct actgtacgaa
    11461 catggcaaat aagggaatga accctaacac cctgcaatac atcatgggac acgcaaacat
    11521 aaccatgaca ttagggtatt atgctcacgg tactttccag tctgcaaagg cagagttgga
    11581 aaggctggct tcttaatatc gaaaatgtat cttactactt atttactact tttggttgca
    11641 ttttcatgct ggtaaatgcc agcttatgcg aggtatcttc caaaaagaaa atgcccatac
    11701 agcccgaaaa tacgggatat atcggcattt accaacttat gaaaagataa tcagaaatta
    11761 gtaagttttt atatcaaaaa aatgattact gtaaagaaat cattttttat tataatcact
    11821 gatacatcaa atattctaaa taaaattttt atttatctgg aattgtatat tttttctata
    11881 atattaacta cagcgtacat tgcccaagca cagatagcca atacaaatac tcccatcatt
    11941 actaaatcta atttaaatac ttgagaacca tatactatca agtagcctat tccatatctt
    12001 gaaactaaaa attctccaac tattacacct acccatgcca taccaatatt aattttagtt
    12061 aaatttatta aatttcctgt gtttgcaggt aatatgagtt taaataatat ttgagattta
    12121 gtagctccaa aactttttaa catcttaatt ttttcttcat ctatattcat aaaataatta
    12181 taagctgaaa gtatagtaac aacaacagaa atcgttacag ctgttacgac gattccttct
    12241 attccagcac ctacccaaac tataattata ggagctaaag cagtcttagg aagagcattt
    12301 aaaactacca aaaatgggtc taatattttt gataattttt ctgaccacca aagagcaatt
    12361 gctaccaaaa tacctaatac agtacctata acaagaccaa gaacagtttc atatacagat
    12421 attccaatat gtttaaataa ttgaccacta aatgcatatt gaataaataa attgtaaata
    12481 tcacttggtt tgctaaatag aaatgtattt ataacattta agtcagctaa aagttcccag
    12541 attacaataa aaccaattaa aattaatagc tggtagaata atacatttct tttttctctt
    12601 tttacacctt taacatagtt tatatatcct tcagatcttt tattaagcct catgtgtatc
    12661 tagctccttc cataatatgt cgaaatactt ttgaaaatca ggaactttac gtgttttgag
    12721 aggcgttttt gttccatcca tgttaagttc aatatcgtaa atatttttta tggtagctgg
    12781 tcttttagat agtattgcaa ccttatctga tatgcttatt gcttctgcta tagctaaaaa
    12841 agtgcaacta attgcttaaa gaaacagaat tatcaacttc agcacccata taaacaatat
    12901 taagatttcc taaactgcta tcccaaacga tactattaat aatagtagat aataacaatc
    12961 tcttatcatc taaactggca ttatcaactt catcattaaa tctcttcaaa ttactaacaa
    13021 taatatcaat attaatactg tcactactaa tattgatgtt actagattcc aaaatattaa
    13081 tcttatcctt taaaatacta atctcattat ttaggctctc aatctgggaa actatataat
    13141 cagaagcagt actaccagta ttttttgcaa gctctataac taaattttta ataagtcttt
    13201 ccttatctaa aatttgattt ttaagtaaat tagtctcaga tttaaaaata ttaaaaacat
    13261 tatcagtctt aatgttatta ctattgaatg cacttataat agactcttct ttacaattct
    13321 taattttatc tataactaaa ctttcaacta atggaccatt aagattttta cagttgcaac
    13381 tatcagaccc aagtgttttt ttagtaccac aaatataata atactttaaa tccttgtcag
    13441 tttttttgcc tttataggta attctcatat tagaaccaca tttaccacat tttataagac
    13501 cagataaaag agcagttttt ccagttgata tccttggagt tttatcacga tttttatcta
    13561 attgattttg tacttcaagc catatttcag gttctatgac tccatggtgt tttgcaattg
    13621 ctgctattga gttagatgta tttttagcat aggtaaggat tccacatttt ctatctggag
    13681 tacctacaac atccatacca ctatttttaa ggtaatctaa aatttcatca ttagctttta
    13741 catatgctgg atttctaagt attctagata aagaactagg gtcaaatttg ccaccacgag
    13801 gaccccttat tccattatta tagacatatt tatataactt agataaggac ctaagttcta
    13861 aatatttatt gtatattagc tttacaatct ccatttgttc atcatttact tgaagcttat
    13921 acatacttct ttcttttaga ttttcatcta agaatgtgat tttttcactg ttgaatccat
    13981 gaggtgtatt gcctccaagc catctaccac tacgggctaa ttcatacata ttgtctttta
    14041 tacgttctgc tattgtttct ctttctaatt gagcaaatac acttgatata aacatcatag
    14101 ctcttcccat tggagttgaa gtatcaaatt gttctttgat agatataaat gatatgctta
    14161 gttcatttaa tttttctatt aaagtagaga agtcagatac atttctcgat atcctatcta
    14221 atctataaca aactaggtaa ctaaatttct tatctttggc atcctgcatc attttcttaa
    14281 attgtggtct atctatattg ctaccactaa atccctcatc ttcatatatc aaaaaatctt
    14341 ttacaccaat agactttgca taatcaatac ataattgtat ttgattttct atagaatcac
    14401 cttttccagt aaatcttgat tttcttgaat aaattgcagc tttcaaaatt aaaaccccct
    14461 ataagttagg atatatattt gaaactattt atctacaacc ttttaagtaa acttattaga
    14521 atgaatttat taattaggta aatttatata attctacttt ttataatata tgactattta
    14581 ttttatttct ttactattca agttctaaat caataataaa ttttgatatt taattgtatc
    14641 aggacaaatc tctaatttca tagattatta atataaaatc ataggttagt gtgaaaaagt
    14701 tgaaatttaa atattttaaa agataatttt tttgaactaa taggtataac aaaaatttat
    14761 agggggattg catatggaaa tcaatgttat agaaattttc cctaaagata aagctaaact
    14821 taataaaata gaaatggata aagctagttg gtttgtaaat ataataagta aaaaatatcc
    14881 taaagaagct ttaaatgaag catttagtac tttagaaaaa gaattaaata taagtaaagc
    14941 taatacataa gctttgatta ttgattttat atactattgg ttttatacgc tatgacttga
    15001 cattatatta atcaaatagt atatttttaa atatagcaca atgaagtgtt aaaagagcaa
    15061 tggagctcca tagataaagt ctatggagct tttttgcgta tttaacttaa ggaggatagg
    15121 actttgaata actttgagat taaaactaga ataaaatttg gagaaggctc actaaaagct
    15181 ttgcaagaat taaaaaacaa aaatgtacta ataataacag acccttttat ggtgaaatca
    15241 aaaacaatag ataaaataac atctaattta ataaactcaa catatcaagt ttttgaagaa
    15301 atagtaccag acccaccaat agaagtagta gtagcaggaa tagaagcatt taaatctata
    15361 aatccagacg taataatagc attaggtggt ggttctgcaa tagatgcagc aaaatctata
    15421 atggactttt ctaaaaaaat attaaaaatt aacgaagtag agtttatagc aataccaaca
    15481 acaagtggaa caggttcaga agtaacatca tttgctgtaa taacagatag tcaaaaaaaa
    15541 tgtaagtatc cattagtgag tgatgattta cttccagata tggcaatact agacccagaa
    15601 cttgtaaaaa ctgtaccaaa ttttataaca gcagatacag ggatggatgt attgacacat
    15661 gctatagaag cttacgtatc tacaaattct aatgactttt cagatgcact agctgaaaaa
    15721 gctataaagt tagtatttaa atacttaata aaagcatata aagatggaaa tgacatagaa
    15781 gctagagaaa aaatgcacaa tgcatcttgt ttagcaggta tggcatttaa ccaagcatca
    15841 cttggcataa atcattctat tgcacatgta ttaggtggaa aattccatat accacatgga
    15901 agaacaaact ctatattact tcctcatgta atagaatata attcatcaat agtaggatat
    15961 actaacacaa cttactctgc tacagctaaa aaatatgcac aaatagcaga attagtagga
    16021 cttgggagtg ctaatataag aatatctgtt agaaatttag taaatgaaat aaagaaacta
    16081 caaaaagaaa tgaatatgcc aactaaattg acacaatgca aattaagttt agaagatata
    16141 actaatgaag aaagagaaat agcaaaactt gctataaaag atacttgtac attaactaat
    16201 cctaaggtac caactgaaga tgatataata aacatattaa agaacattaa ataactacat
    16261 tttattacat gtaaatataa tattatacaa atagggaaaa tgtttttaaa aatataaatt
    16321 atatattgac aaatataaaa cataaaacta taatgaaagt atcacaaagg cgtgatactt
    16381 tagtagaaag caatggagct tcttaggaat attaatatta ttcttatgga gctcctttta
    16441 ttttaatcaa atagcttttt aataaactat attcaaagaa agcagggaat aaatttgact
    16501 gaagaatcta agcaaagagt tattcaagaa tatgttcctg gaaaacaggt tacattagca
    16561 catatcatag ctaaccctaa tgaagatata tataagaagt taggattagt acttgataaa
    16621 aaagatgcaa taggaatact tacaataaca ccaagtgaag cgtcaataat agcagcagat
    16681 gttgctacaa aggcttcaaa tgtatcttta ggttttatag atagatttag tggttcagta
    16741 gtaatatcag gtgatgtaag ttctgtagaa tcagcgttaa atgatgtttt agaagtctta
    16801 ggaaatatgt taaacttctc atctacaaaa atcacaagga cataataata caatgaagaa
    16861 tataatattt atgggaaaga caggtagtgg taaaactacc ttatgtcaaa aactagacca
    16921 gttagaatta aagtataaaa aaactcaatc agtggaactt tataataatg caatagacac
    16981 tcctggtgag tatatggaaa atagaaacct atataatgcc ttaataacaa catcagcaga
    17041 tgctaaaatt atagcaatag tgtatgatgc cacacaagaa gaaaattata tagcaccagg
    17101 ttttgccagt atgttttgca aagacgtaat aggaattata actaaaataa ataaagctac
    17161 tgaaaacgaa gtcaatatag cttatgaaag actatcacta gcaggagcaa gtcaaatctt
    17221 taaaatagac acagttgata atattggact tgaaaaatta tttaaatatc tagaaaaata
    17281 taaaaatata gatgaagttt aaggggaaat atttttttat tcaaaaatat tattaaagta
    17341 tgataaaata aaaaaatgta taaactattt taagaagatt taatctttaa gcgaggtagg
    17401 aacatgggga aaaaaatact attggttgat gatgaaccac tgttaaggat ggatacaaaa
    17461 gatatattag aaagtcatgg ctatgaaata ataggcgaag caagtgatgg atttgaagct
    17521 gttgaaatgt gtaaaaaaca caaacctgat ttagttataa tggatataga gatgccaata
    17581 cttgatggta taaaggcagg caaaataata tgtaaagaaa atatagctgg tggagtactt
    17641 ttattaactt catttgaaga taaagaatac gtagaaaagg ctaaaagtat aggtgcttat
    17701 ggatatttag taaaaacagc aagtgaaaaa tcacttatcc caaccataga aatgtgttta
    17761 aataaggtaa atgaatttga aaaaatgaaa aaagatttag aaaaagtaaa ttctaaattg
    17821 aatgaaagaa aattagtaga aagagcaaaa ggtatactta taagagagtt taagatttct
    17881 gaggatgaag catacactag aataagaaaa ttaagtatgg ataaaagaac tacaatgatg
    17941 gaaattgcca aaatgattat aataggatac gatgactaat acgataaaaa aaatatcaac
    18001 tgcacaaaca tacttaaata ataacgaaat tgaaaaaatt atagaagtat caaaatcctt
    18061 agatttaatg gcttcttttt atgaagctga tgtttttata gatgtactaa gtaaatttga
    18121 tgatgaagca attgttgtgg cacatggtag acctaaagaa aagtcaatgt actgtgaaaa
    18181 tgttataggt aaaaaggctt taattgaaaa tgaaccagga gttataaagt gcttaaaaac
    18241 aggagaaaga gtaagagata ttaaagcttt aacacaggaa tataaactgg tcaaacaaaa
    18301 tattcagcca ataacactag atgacaaagt tttagcagta ctaatagttg aaaaagatat
    18361 aagtagtgaa gttaagaatg agtttaatgc tagtgaagac gaagaaaata aaaatttaca
    18421 tcagtttata aaacttattg gaaataatga ctttttagtt gataatttaa attcagccat
    18481 attaatattt gataaaaatg gaaaattaaa aattaaaaat cgtattgcaa ctgagatata
    18541 caaaaatctt gggtttggat atgatataca agatatgcat tacaatgatt tagatataga
    18601 aaccaacacc tttgaaaata tattaatgga tgaaaattat gatgagacaa atgaagtttc
    18661 aataggtaat atgtttttta aaataaagac catatacatc aaagatgatg aatttaaggt
    18721 ttgcaaaata gtacaagata taagtgattt aaagagaaaa gaagaagaat tagttttgaa
    18781 aacagtggct ataagagaag ctcatcatag agtaaaaaat aatcttcata cagtaatatc
    18841 tataataaaa aaacaaagta gattatctca aaatgatgaa gtaaagcagt gtttagataa
    18901 cataataaat agggtatttg caatactttc gactcattat ttactatcta aagaagttga
    18961 taataatata tctatacgag aaggtatcaa tttattagtg tcaaatattc aaggtggcta
    19021 tttatttagt aaggatatag atatacgtat aactggtgaa gattttaaaa ttagtggaga
    19081 aaaagcaaca gcaatacttt tggttataaa tgaaatacta caaaattgtt atgaccatgc
    19141 attttcggat agagaacatg gtactataca aatattaata aataaagata acgactatag
    19201 aaatattgct attatagatg atggaattgg atttgatagt aataatataa ataaaaatag
    19261 cttagggaca tatataatag atagttatat aacacagatg ttaaaaggaa atatagagag
    19321 aaaaagtagt gagaatggta cagaagtatt aattactata cctacacaaa ttaatattta
    19381 aataataact catctacaaa gtagtagttt taattgagca aagaggctta aggttattaa
    19441 tagattaagt taattgaatg tatttataaa aattataagt atatattcaa tttaacaggt
    19501 atttattata actttaagcc tctttgcttg tttaagacat acttaaattt taggaggtga
    19561 gaaaatgaga gaagagttat taagtgttgg tattgacatt ggaacaagta ctactcagtt
    19621 aattttttct aaattaatag tagaaaatac tgaatcaaat ttttcggtac ctagaataag
    19681 tatagtagac aaagaaatta tttataaaag caaagtttat ttcacccctc ttatttcaaa
    19741 taatgaaata aatggtcaac aaataaaaga tatagttgaa aatgaatata aaaaagcaaa
    19801 tatatctaaa gaagatatac atacaggagc agtaataata actggtgaaa cagctagaaa
    19861 agaaaatgca aatgatgtac ttcatacttt gagtggattt gctggggact tcgttgttgc
    19921 aacagcagga cctgatttag aaagtataat atcaggaaaa ggagctggag ctcatattta
    19981 ttcaaaagaa cattcaacta caattgtaaa tatagacata ggtgggggaa ctagtaacat
    20041 agcctcattt aaaaggggag aagtaaccga tactgggtgt ttggatatag gtggaaggct
    20101 tgtaaagata gataaaataa gtaaaaaaat aacttatata tcacctaaaa tagataaaat
    20161 cataaaagat aataatttaa atcttcaagt aggtacaatg gctactgtag aaaatacaaa
    20221 gccaatagtg gatataatgg ttgacttatt aatggaaagc ataggactaa agaaacagac
    20281 acctttgttt gattttataa taaccaataa atcaataagt atagatgaaa atattaaaaa
    20341 tgtttcattc tctggtggag tagctgatta tatttactat gatggagaaa taaaagatta
    20401 ttttgaatat ggtgacttgg gaattttact tgggcaagca ataaaaaatt gtgaatacct
    20461 taaaaaagta aatgtagtta aatctatgga aacaataaga gccacagtgg ttggagcagg
    20521 ttctcatact actgaagtaa gtggaagtac aataacttac actagcgaaa agtttccact
    20581 taagaacttg ccagttttaa aattatcaat tgatgaagaa acaggtactt caaaacaaat
    20641 cagtgaagct ataaaaaata aacttaattg gtttaaacta gaaaatgatt tacagaaagt
    20701 tgctatagcc atgataggaa agaaaaatcc aaccttttta gatatacaag agtatgctaa
    20761 agggtttgta gatggaatgc aacaaatcat agaaaatgat ttacctttta tagtaattgt
    20821 tgaaaatgat atggcaaaag tgttaggtca agcaatatat gcattattaa attatgaaaa
    20881 agaaattgtt tgtatagaca gtgtcaaggt tgaaaatgga gactatatcg acattggaaa
    20941 acctatagtt gaaggtaaag ttttacctgt ggtaataaaa acattagttt ttaattaata
    21001 gaaggaggta agtaaatgat tttaaataca aaattatttg gacgtactta tcagtttaaa
    21061 ggcttatatg atgtaatggc taaagctaat gaagaaaaat caggagataa attagcaggt
    21121 cttgcagcag aatcagctga agaaagaata gcagcaaaag ttgttttatc acacataaaa
    21181 ttggaggata taagaaataa tcctgcagtg gcatatgaag aagatgaagt aacaagaata
    21241 atacaagatg ctgtaaatga aaaagtttat gaagaaataa aaaattggac agtgtctgaa
    21301 cttagagaat ggctattgga ttcaaatact acaagtcttg atataagaag aatatcaaga
    21361 ggattaactt ctgaaatgat agcagcagtt gcaaaattaa tgtcaaatat ggacttagtt
    21421 tatgcagcta aaaagataaa ggttactgct cactgtaata caactatagg agaacaagga
    21481 acattatcag caagacttca acctaatcat ccaacagacg acccagatgg aatacttgca
    21541 tcacttcttg aaggtttaac ttttggtata ggagatgcag tacttggatt aaatccagtt
    21601 gatgactctg ttgagagtgt tactaaagta ttaaaaagat ttgaagaagt aaaacaaaaa
    21661 tatcaaatac caactcaaac atgtgtattg gcacacgtta ctacacaaat ggaagcaata
    21721 agaaatggtg ctcctgcaga tttaatattc caatctatag caggttctga aaaaggaaat
    21781 gaagcatttg gatttaatgg cgacactata gaagaagcta gacagttagc cttaaaacac
    21841 ggtacagcta caggacctaa cgttatgtat tttgaaactg gacaaggttc agaattatct
    21901 tcagaagcac atcatggaat agaccaagtt actatggaag ctagatgcta tggatttgct
    21961 aaaaagtatg aaccattctt agtaaataca gttgttgggt ttataggacc tgagtactta
    22021 tatgatgcta gagaagttgt aagagcagga cttgaagacc actttatggg taaactacat
    22081 ggcttaccaa tgggtgttga tgtttgttac actaaccata tgaaggctga ccaaaatgat
    22141 atggaaaact tagccatact attaacaaca gcaggatgta cgtattttat gggaatacct
    22201 catggagatg atgttatgct taactatcaa acaacaggat accatgaaac agcatcactt
    22261 agagaaatgt ttggactaac agcaataaaa gaatttgatg cttggatgga aaagatggga
    22321 ttctctaaag atggtaagtt aacagagttg gcgggagacg catctgtatt attaggatag
    22381 gaggtattta atatgaatga gaaggattta aaagcattgg tagaacaatt agttggacaa
    22441 atgcttggag aattagatac taatgttgtg tctgagactg ttaaaaaggc aactgaagtt
    22501 gtagtagaca acaatgcttg tatagatgat ataacagaag ttgatataag aaagcaatta
    22561 ctagtaaaaa atcctaagga tgcagaagct tatttagata tgaaagcaaa aacacctgca
    22621 agattaggta taggaagagc tggtactaga tataaaacag aaacagtttt aagatttaga
    22681 gcagaccatg ctgctgcaca agatgctgta ttctcttatg tagatgaaga atttataaaa
    22741 gaaaataata tgtttgcagt ggaaacttta tgtaaagata aagatgaata cttaacaaga
    22801 ccagatttgg gaagaaaatt ttctccagaa actataaata atataaaatc taaatttggt
    22861 acaaatcaaa aggttttaat attagttgga gatgggctta gctcagctgc aatagaggca
    22921 aatttaaaag actgtgtgcc agctataaaa cagggtctaa aaatgtatgg tatagattca
    22981 agtgaaattt tatttgttaa acattgtaga gttggtgcta tggaccactt aggtgaagaa
    23041 ttaggttgtg aagttatatg tatgttggtt ggagaaagac caggattagt tactgctgaa
    23101 tcaatgtcag catatatagc ttataagcca tatataggaa tggcagaagc aaaaagaaca
    23161 gttatatcaa acattcacaa aggtggaaca actgcagttg aagcaggtgc tcatatagct
    23221 gaacttataa aaactatgtt agataaaaaa gcttcaggaa tagaccttaa ataaagtcga
    23281 gggagtgtag aatatgaaaa atgatgtaat tcgtcctaat atactaggaa ttaaaataat
    23341 ttcaaatata agtccagaaa tggcacaaaa actagaatta aaatcacatc acaaaagctt
    23401 aggtttaata actgcagact gtgatgatgt tacgtataca gctcttgacg aagcaactaa
    23461 agcttcagaa gttgatgttg tatatgcaaa atcaatgtat gcaggtgctg caaatgcttc
    23521 aacaaaactt gctggtgaag tattaggaat aatagcaggt ccaagcccag cagaagtaag
    23581 aagtggtcta aatgcagtag ttgattttct agagtatgga gcaactttta taagtgcaaa
    23641 tgatgatgat tcaatagcat actatgctca ctgcgtatca agaacaggta catacctttc
    23701 agaggtagca ggaataagag aaggtgaagc attagcttat ttagtagcac caccacttga
    23761 agcaatgtat gcactagatg cagcaatgaa agctgcagat gttaagatgt gtgaattatt
    23821 tgcacctcca actgaaacaa actttggtgg agcattactt acaggttctc aatcggcttg
    23881 taaagcagca tgtgatgcat ttgcagaagc agtaaaatca gttgcagaca atccaacagg
    23941 attttaagga tagttagatg gatgctatag gcttaataga agtaatagga tatgttgctg
    24001 caatagaagc ttctgatgct tgtttaaaat ctgcaaatgt taatattgta agagttgata
    24061 aggttggggc aggtattgtt actttaacaa tatgtggaga tgtcggtgct gtaaaagctg
    24121 ctttagaagc gggtgaaata gcagcttcca gagttggtac attaagaaca tcacatatta
    24181 taccgagaat ccataatgaa gtaacaaatg ctttattcaa aactaaagaa cctaaagtct
    24241 gtgaagtttc agaagataaa gaaaaaaact ttgagattac attggaaata gctgataatg
    24301 tatcgaaaaa tttatcagaa aaagaaaatg taattttaga tgtcaatgaa aacagtggag
    24361 atactgaaaa tttatatagt gatatagata aaacaaacaa aaaaattgaa acagttgatg
    24421 atagtttaac agaagctaat gaggaaaaaa tagaaaacac taatgataaa gaagtattgg
    24481 aacaagttaa aatagaaaat tccgattttg atagagatga cctatcaaag aacagtgtaa
    24541 aaaaacttaa agctatggct aaaaaattag attcttcaat aacttataaa gacttaaatg
    24601 ttcttaaaaa agaagaatta ataaacttag ttaaaaagct tagcagaagg gatagatagt
    24661 tatgacactt ttagataaag atttagtatc tatacaagaa gtaagaactc ttgtaagaag
    24721 atctaaagtg gctcaagaga aactttctaa aatgagtcaa gagcaaatag ataaaatagt
    24781 aaaagctgtt gtagatgcag catttaataa tgctactaaa ttagctaaaa tggcaaatga
    24841 agaaactgga tttggaaaat gggaagataa agtaattaaa aatacttttg catctatggg
    24901 agtttatgaa actttaaaga acacaaaaac tattggaata attggtgaag ataaagaagc
    24961 caatacgata gatatagcta caccagttgg agttgttgca ggtcttatac cttcaacaaa
    25021 cccaacatca acagtaatat acaaaactat aatatctcta aaagcaggaa atactatagt
    25081 tttctctcca catccaaatg caaaaaactg catacttgaa acagttaata taataagtga
    25141 ggctgctata aaggctggag ctccagagga ttcaatatta tgtataacta atccaagtat
    25201 agttggaacc aatgaattga tgaaacataa agatacaaac ttaatactag caactggagg
    25261 agaagcaatg gttagagctg cttactcttc aggaacacca gctattggag ttggaccagg
    25321 aaatggacca gcatttatag ataaatcagc aaatgttaaa ttagcaatca aaagaataat
    25381 agattctaaa acttttgata atggtgttat atgtgcatca gaacaatcta tagtaataga
    25441 aaaatctatg gaagaaactg ttttaaaaga gcttaaaaat caaggtgcat atgttttaaa
    25501 tgaagaggaa agtgaaagat tagcaaaatt catattaaga gctaatggta ctatgaatcc
    25561 acaaatagtt ggtaaaagtg ttgaggtaat agcaaattta gcagacttaa caaatgtacc
    25621 taaaaataca aaagttctag ttgcaagaga aaataaagtt ggtcacaatg tagcctattc
    25681 aagagaaaaa cttacaccaa tactagcgtt ctatgttgaa gaaaatgtag aagctattat
    25741 gaacagatgc agagaaatat tgttaaatga aggtgcaggt catacattct caatgcatgt
    25801 aaatgatgaa gaattggtaa aaagatttgc ccttaatatg ccagtatcaa gaatacttgt
    25861 gaatactcct tcagcacttg gaggaatagg tgcatcaaca aaccttgtac cagcactaac
    25921 acttggttgt ggtgcaatag gtggaagttc aacttcaaac aatataggac cacttgattt
    25981 aataaatgtt aaaagagtag cttatggaat caaagaaata gaagaacttg gaagagataa
    26041 atctcaagtt gaaaaatcaa tgtttgactc aatggataaa gaagaattaa taaatcttct
    26101 tgttcaaaaa ctagtcaaag aactagcata actaaaataa acaatgaaac ttatggctat
    26161 cgctataaat ttctaaaaat ataaactata aaaaactata aaattaaatt tttggaggat
    26221 aagattatgg caagtgcaaa cgcattagga atgatagaaa ctaaaggatt agtaggagca
    26281 atagaagcag cagatgcaat ggttaaagct gcaaatgtac aattagtagg aaaagagcaa
    26341 gtaggtggag gattagttac tgtaatggta agaggagatg ttggagctgt taaagctgct
    26401 acagatgcag gagctacagc tgccgagaga gttggagaac taatatcagt tcatgttata
    26461 ccaagaccac actttgaagt agatgctata ttaccaaagg tatcagctga gtaatataag
    26521 aataattata aaatttaaat tttgattgaa aaagaggcta tctcaaaaat gagtcttact
    26581 aataaactca atgtattttg aggtagtctt ttttatacat ctaataggag atgtgataaa
    26641 atgggtgttt taacagaaaa cgaagtaaaa agaaaaattg gaaaaaacaa aaataatata
    26701 actgaatttt atatagaaaa aggtcaaata ataactcctt ctgcaaaatc ttatttagct
    26761 gagagaagta ttgagcttaa atatgttgat aaactttcag atgtaaacaa tgaacctaaa
    26821 gaagttgtaa aagaagtagt taaagagaaa aaatataaat atactactgt atttggcgcc
    26881 aaattggatg aaaaaccaga acatatgact caattaaatg gaaatctttt agtttttaaa
    26941 gaccataaaa gaataatatt gagaggaaaa atagattctc ttgaatcaga aatactaaag
    27001 gtacagatac tttgtcagaa actagatatg ccaaagcttg ttaaggaatt gcaagaagta
    27061 ttagactttg taagaaatat aatgagatgt gaagttttag atgaaaagct aggggacttt
    27121 aaacttttag gattaactcc tcaagaactt agagaacaat ctcactatcc taaaaaatac
    27181 tttggtatag gacatgagtt cccaagttat gaaatgggag aagtagtagt agctataaat
    27241 agtataagaa gtaatacacg agaggttgaa cttgcagcct atgaagcatt taagggtgag
    27301 tatggaaatg ttcacagaga agatttaata aaggcactta atagattatc gtcagtattt
    27361 tggataatga tatataaggt tagaactaat aagtataagt agttggagga cataatggag
    27421 aatctattaa atgaaatagt ggaagaagta ataactagag ttaaaaaaga agcatttata
    27481 gaagttgaag catcaggaag acacgttcac ttaagtagag aagatgtcga taaattattt
    27541 ggagaaggat atactcttac aaaactaaaa gacctatctc aaccaggtca atatgcatgt
    27601 aaggaaagag ttacaataac tggtcctaaa ggaagtataa aaaatgtagt tgtacttgga
    27661 ccatgtagaa atgaaactca ggtagaaata tctttaacag atggttcaac tcttggacta
    27721 aaagctccta taaaacaaag tggagactta gaaggtactt taagtattaa aatatcaaca
    27781 caatatggtg aagttgaact tgataagggg ctaatggttg ctaaaagaca tatacacatg
    27841 actcctaaag atgctgaaaa attcaatgta tgtgataaag agatagttga agctaaggtg
    27901 atgggtcaaa gacctttaac atttgatgat gtagtaataa gagtgagtga cagttttaaa
    27961 acttatatgc atatagacta tgatgaagcc aatgcatgtg gttattcaaa aggaactgtt
    28021 gctaaaataa taaagaaagc ataaatttaa cctactatat aaattacctc tagggaggat
    28081 ttaatatgaa ttatgataac cttgtagatt taataacgga agaaatctat aaaaaaataa
    28141 atagtaatga aataaaaata tctaataaac ctaaagctgt gattgtattt gaacaagata
    28201 acaataaatt taacttatta aaagatggat ttgaaatagt agaatttgat aaaagtataa
    28261 gggaatgtga aatagtgata gtttcaagac tttgtatgag ggggctatcg aatatagcac
    28321 ttggaaattc aacaagtgat gaagaaagat ttatactaaa aatgattatg aatggcaaaa
    28381 aagtatatgt cctagatgaa ggaattgaat acaaaaaata taaggatact gcaccaaaag
    28441 cactatataa gaaatttatg tcatttgaag atgaaatatg taaatttggt gtagaaatta
    28501 taaaagactt aaatgttata actaaaaata agttaaatat aaagaaagaa ctagaaagta
    28561 ctagaggttc taaaaaagaa gatacaaaag ttttagataa agatatttta aatttaacca
    28621 gtgtagaaag tgtaaaaata gataatgaat ttagtttgga tttaaggaat aaaaaactta
    28681 tatcggaagc tgacttaaga aaaccaacta taaatggagt taaaaacata ttagttaata
    28741 aaaaaagtat aataacacca ttagctgtag attttatgag aatacaccat ctcaaactaa
    28801 agaaactgta aggaggtaat tttatggata taggaaaagt tgtaggtaat gtttgggcta
    28861 caagaaaaga tgaaaaatta tgtggccaaa aacttttagt tgtaaaaatt ttaaaaacta
    28921 aagacacata caaggaaggc ttcatggttg cagccgataa tgcaggagca ggaaatggag
    28981 acttagttct tatatccaaa ggttcctcag ctagagagtc gattgaaaaa tctcatgttc
    29041 cagtagatgc aactatagtt ggagtagtcg attcgtttga ggtgtttgat gaataaaagt
    29101 ataggagcta tagagtttaa aagcattgct aaaggtatag aagtatccaa tgaaatgata
    29161 aagaaatctt cagttgatgt attgtactta aaaagtattt gcccaggtaa atttctaata
    29221 atagtaggtg gagaaacttc ttatataaat gaatgtgtag attatggaat aaaacttgga
    29281 gaaggatata ttgtagataa cttcgtaata aatgcaattt cacaagaaat attagatgga
    29341 tttaaaaata agtatcaaaa gctagatagt atagtctcta taggcgttgt tgaaagtagt
    29401 aaaatatgcg ctggaataaa aatgcttgat aagactttaa aatctggcga cttagtatta
    29461 gtaaaacttc aattatcttt tgctataggt ggcaaattag tatatatagt agcaggagat
    29521 ttaagtagtt tagaatatgc attaaaagaa agtgaaaatg tagtaagaga aaaagaagta
    29581 atatataaga ctgtaatacc atcagtagac agtcaaataa taaaaagtct aataaaataa
    29641 tggggggaat tatgagtata aacgaaatta taatctatgt aatggtagtc ttcatggtac
    29701 ttggagctat agataaatgt ataggtaaca aatttggtct tggagaacaa tttgaggaag
    29761 gtataatggc aatggggtca cttgcagttg caatggttgg tgttatatgt ttagcaccag
    29821 ttcttgctga tgtattaaga ccaattgtag taccagtatt taatatactt ggagctgacc
    29881 cagctatgtt tgctggaagt ttattagcta atgatatggg tggtgcgcca cttgcacttg
    29941 aacttgcgaa agaccctaat gctgggttat ttggtggatt aatagtaggg gctatgatgg
    30001 gacctacaat agtatttata ataccagttg cgcttggaat aattgaaaaa gaagaccaaa
    30061 aattcttagc aacaggaata cttgcaggta taataacaat acctattgga gcattcgttg
    30121 gtggattagt tgcaggattc gaggtaatga tggttcttag aaacttagtg ccaataataa
    30181 tatttgcagt agttatagca cttggattat taaaattcga aaatgctatg ataaaaggat
    30241 tcacatactt tggaaaaggt gtagtaatag ttataacttt aggacttgct gctgccatag
    30301 ttgaagcttt aacaggaata gttgtaatac ctggaatgaa accaatcagt gaaggtatag
    30361 aaatagttgg agatatagca atagttttag caggagcatt cccattagtg tttgttataa
    30421 caaaggtatt taataaacca ttaatggctt taggaaaagt tcttggaatg aatgatgtat
    30481 cagcagcagg ccttgttgca agtttagcta actgtatacc aatgtttggt atgatgaaag
    30541 atatggacaa tagaggaaaa ataataaatg tagcattctc tgtatcagca gcattcgtat
    30601 ttggagacca cttaggattt acggcaggat ttaattctaa tatgataaca ccaatgatag
    30661 ttgctaaatt agttggtggt ataacagcag tattgttagc tatggttatc gcaaataaga
    30721 cactaaagaa ggagaatgta taagatggat atatcaaata tagataaaaa tttaattgaa
    30781 acattagtaa gacaaataat agaagaaaaa ataagtggaa ctaaagacac agtagatttt
    30841 gttagaaata aagacattag tggaataact tctataaagt taccaactgt aaaagttagt
    30901 gaatctgata gattagatac agggaatcca agtgatgtag tttacacaaa agatttattt
    30961 acattagagg aaagcccaag attaggttgt ggtatgatgg aaatgaaaga aacaactttt
    31021 gattggactc taaattatga tgaaatagat tatgtaatag atggaacttt agatataata
    31081 atagatggaa gaaaggtttc tgcttcttca ggtgaattaa tattcatacc aaaaggaagt
    31141 aagatacaat tttctgtacc tgattatgct agatttatat atgtaacata tccggcagat
    31201 tgggcatctc aaaattaata aaaatcaagt taagttaata atcaaataaa taatttaaaa
    31261 tacaaactct taaataagca cgcatattta aaaaagctat gaattaaaat tcatagcttt
    31321 ttttataaag aatgttatat tttagacgta ttttttctat atttactggg agatatatta
    31381 tattttttat taaataatct aataaaatgc tctacatttg gataaccaat actattttac
    31441 tgataatctt ttccttatca ctaatcttac attttaaaat attattttta ctcgtaatat
    31501 tatcataaga atttgtttct tatttaaaac taattagaat tataaagttt attgccatgt
    31561 tattaataaa ataaatccag ttaaatcgag tgctagttaa agtaataaga aacttttaca
    31621 atggtttcct ttatcgattg aaataaaagt taatatggta taatatctaa agagagaatc
    31681 ttatcaatta gaatatgcat agaaacaagt ggcttaaaag gagacgttat atggaagaga
    31741 tagtaaagaa ggaacaagca agtatgaatg atattttttt gtatcttaaa gctaaatcaa
    31801 actcattata taaatttgta atattatata atgagtttat caataaacct aaagattatg
    31861 gaactgggga acttataaac atggttgaag tacatatgct aacagcgatt gaagaaaatc
    31921 caggaataag tccaactcag ttagctaaaa tatggaacag aactaaaggt gcaatatctc
    31981 aaactatatc taaattggag aaaaagggtt atataactaa agaaaagaaa gaaggaaatg
    32041 caaaaactat attactatat ccaaccacat caggagtaga gttaagtaag gcacataaac
    32101 tatatgacac catagatgtt acaagaacat ttgaatactt aatcaaggag tgtacattag
    32161 aggagataga tagtttttat aaagtaattg atttgtttat taatttatta gaagaatctc
    32221 cgcaggaaaa taatgattct gaaaaagtgt agctgagatt gaagttgaat aaagagaaat
    32281 agatattata gaagtagtac ttaagtacac attatataaa aatataatag gtataggatt
    32341 aaaaagttta gtggtttaaa gtttaaccac taaacttttt taatgtctat aatctactat
    32401 tatttaattt actaaaaata aaaaaactca ttatattaag atagaaatag aaaaataact
    32461 agaaaaatac tataatatat cagcttaata cagaaaaaag ttaaaaaatt tgagaaaaat
    32521 aaaaatgaaa acgttttata ttgacataga gaaaaagtag tgataccatt taaatatagt
    32581 ttagtagcta aactatattt aaattataat aactatttta gggggatgtt atgaatttaa
    32641 aacaattaag tgaaaaatac gaagaatatg taattcaaat gagaagagaa tttcataagt
    32701 atccagaatt atcttttaaa gaaataagaa caacccaaag aataagggaa gaattacaaa
    32761 aaataggggt cccttttgta tctattgaac caaatatcgt aatagctact atacaaggca
    32821 aaaatgaagg taagacaatt gcaattagag gagatataga tgcgcttcca atgcaagaag
    32881 attcagatgt tgaatacaaa tcagaatatg atggaataat gcattcttgt ggacatgatg
    32941 ctcatggagc tatgttacta ggacttgcac atatgctaaa tgatataaga aaagatttaa
    33001 aaggtagagt attattagtt tttcaagcag ctgaagaagt tggtggtgga cacaaggaga
    33061 taatacagta ctttaaggaa aatggaggac cggatagatt aatagctact catgtttggt
    33121 ccgatattga agctggtaaa atttctgttg aaccaggacc tcgtatggct ggtgggtctg
    33181 gttggagaat agacataaca ggtagaggag gtccagatca aagcatagat cctataaagc
    33241 cagcttgtga tatagtttta aaagtatctt ctataccagt taatcatata agtgtactag
    33301 aacaatgtgt tgtacatgca tgtgcaatac atggaggaac tacaatagga aatgttattc
    33361 caaacaatgc agaggtaata ggtggatata gatattttac tgaagaatca ggcaaaaaag
    33421 tgtttgacat tataaagcaa atgagtaatg gtgttggaca agtttatgga gtggatgtga
    33481 aggttactca tactggaggc ataggacctg ttatcaatga tgaagaagca gttaagatgg
    33541 ctaaagaaat agtttctaat atagatggat tggagttaga ttcttatgag ccaatatgtg
    33601 catcagattg ttatggtgaa atattaaaag agtattctgg cttttattgt tatctagggg
    33661 taggtaacaa agaaaaagga ataatatatg cacaacacca tcctaagtac aatatagatg
    33721 aagatatatt aaagttaggt tgcgaattta tggctaaata tgcagttgaa tttttaaata
    33781 aaaataataa ctaaaataaa tctaatttta taaatggggg gatgaaaatg caaggtgcat
    33841 taaaggaaaa taagaaaaaa agtggtggag gatttttagg atggattgaa aaagttggga
    33901 ataaaatgcc acatcctcta gcattattta catatattac actgatagta gtagcattat
    33961 ctgcaatagc aagcttttta ggtttttcag caacaagtcc tgctacagga aagttaataa
    34021 aagttatgaa cttaataagt gcaaaaggtt tagtactatt tatgcaagag tttgttaaga
    34081 acttccaaaa cttccctgtg cttggagtag ttttagttat ggcagttgcc acaggagttt
    34141 gtgaaaagac aggatttttt tcaactgcca taaaaatgag tttatcaaaa gttaagggga
    34201 atgcggttgt atttataata gcttttatag gagtatttgc taatcaagct ggtgatgctg
    34261 cttttgtatt agtaccaact cttgcaggag caatatttta tggattaaat agaaatccat
    34321 tagctggtat attctgtgga tttgcatcag ttggtggtgg atttgcaaca gctgtaattc
    34381 ctgggggatg ggacgttacg ctaacgccaa taactgtatc agctgctcaa actattcaac
    34441 ctgcatttga tatgacatta ttagctagtt attatgcact atttgtatct gcgtttatag
    34501 tagctacagt atcaacaata gtaacggtta aatttataga acctaaatta ggtaagtata
    34561 ctggtaaacc agaaggtata gatgataatc aaggttttga ggtcacaaaa gaacaagcaa
    34621 aagcagcaaa gttagcaggt tttacagttt tagcttatgt agcgttatta attgctttgt
    34681 gtataccagc taatagtttt ttaagaagtc cagaaggttc tttaatattt ggagcaccac
    34741 ttatgtcttg cttacagttt tttatagtaa tactattctt cttgccaggg attgtgtatg
    34801 gaatgagggt tggtaaaatc aagactgtaa aagacttaaa tgatatatta tgtcaatcaa
    34861 tggcagcaat ggcaccgttt atcgtacttg caatagttat aggtcaattc ttaacgctat
    34921 tctcagtgtc taatttagca caggtactag ctataaaagg tggagcatta ctcaactcat
    34981 tgccactacc accacaagct ataatactgc tattcttagt actagtagcg tttataaata
    35041 tatttgttat aagcggaagt acaaaatgga tgatatttgg accagtattt gttccaatgt
    35101 taatgcaatt aaacatacat ccagcattta ctcagtttgt atatagatta ggagattctg
    35161 taaccaatca tttatcacca ttaaatgcat tctttataat acttttagca acagtccaaa
    35221 aatacgataa aaatgcaggt atgggaacta tattctcagc tatgatacct tacactatag
    35281 gttactttgt agtacttgca gttttagtag tagtttggat gacaataggt ataccagtag
    35341 gaataggtgg acaagtttgg ttataaaaca tatttaataa ttttgggagg aaaaaaaatg
    35401 gaaacaactg aaataagata caattttgat gaagtaatag atagaagtgg aacaaactgt
    35461 cttaaatatg atcttaagag tcaatttatg ccagaatctc cagaagatgc actaccacta
    35521 tgggtagcag atatggattt tgcatgtgcc cctgagataa ttaatgcaat gcatgaaaga
    35581 atagacagaa aaatatttgg atatagctct caacaaactg atgattatta tgaagctgta
    35641 tgtggatggt ttaagagaag atttgattgg aaaatagaaa aagagaatat attctttagc
    35701 ccaggggttg tgcctgcgtt aggatttttc acacaaatat taacacaaaa gggtgatggt
    35761 atcataatag aaaagcctgt atactatcct tttgaagata aaataactaa caatgaaaga
    35821 aaagtagtta atagtccttt aaagtttgaa gatggtcatt attctatgga ttatgatgga
    35881 tttgaagaat tagctaaaga tgaaaataat aaggtgttta tattatgtag tcctcataat
    35941 ccagttggta gagtatggaa aaaagaagag cttagaaaaa tagtagacat atgtaagaaa
    36001 tatgatttgt ggataatatc tgatgaaata cattgtgata ttattcgtaa aggtgaaaag
    36061 catataccat tagaagtagc atgtcctgat tataaagata gaataataac ttgtacagct
    36121 ccaagtaaga gttttaactt agctggtatg caattatcaa atatagtaat caataataag
    36181 gaattacaag aaaaatggat gcttgaaaca gattctaaat tagctatatt cctacctaat
    36241 ccattcgcaa tagttgctac taaagttgct tataatgatt gtgaagattg gatgaatcaa
    36301 gtaaatgagt atatagatgg taatattaaa tatgtagaag attttgttaa tgagtatatg
    36361 cctaaagtaa agataataaa atctcaagga acttacttag tttggttaga ctttagaggg
    36421 tatggattag atgcaaaaca gcttgaatat gtaatgctta acaaggcgaa ggtattgcta
    36481 gatgaaggat acatattcgg agaagaagga gcaggatttg aaagaataaa tgttgcttca
    36541 cctagaacaa ttatagaaga gtgtatgaat agaataaaat gtgcatttga aggattataa
    36601 tagtaatatc taaataatat atttgtgtat tttaaaaaaa gactatgcta aaaaaatatt
    36661 tcaaagcata gtcttttaaa gttttatgat gagtttaaaa aatttcaaaa cgttactatt
    36721 cacttatatg tttatattag aaataattcc acaatatact cattttctaa agttgcactt
    36781 ttatacacct tgcttcacca atatcatgtg taaccaaaat agtagactta ttctcattct
    36841 taataatact ataaacatca tcacaaacta ataatctagt ctgataatca agagctgaaa
    36901 aaggttcatc taaaagtaga atatctggat ttacagaaag tgttctaata agcgcaactc
    36961 tttgtctcat acctccagat aattcttttg gatacatact tctaaaatcc cataatccat
    37021 aagtctttaa aaggctttca actctatcta aagatttttt atcttttttg ccttgaattt
    37081 ccaatccaat agttatatta tccattatat ttctccattc aagcaaatta tctttttgaa
    37141 acatatatcc aatatttcca gtaatcttta tatcaccact agttggtttt aaaagattag
    37201 taagaatatt taatattgta gatttaccac ttccagaagg accaagcaaa gttaatattt
    37261 ctccttcttt caagttaaaa ttgacatcct ttaatacttc aagctcgcct tccttagtgt
    37321 agaagttcat atttatattt ttaacttcta ctatgttgtc attcattatg ccacccccta
    37381 taacttttag ctcgtatata ttatgttatt aacaatatga cctatttgta ccatttttca
    37441 taaatataat ataaatattt tgtttattta cgtattttct tagtaacttg tacgtataaa
    37501 ttatagataa ataaattata aggtagggga taaatttgag taacataata acgaatttaa
    37561 tagagtcaat atttactaat ccaataacta tattgttttt acttgcaata actgtgtatt
    37621 ctgtttttaa aataatagaa aataacagag tatattcatt tgtaagttca aaattagacg
    37681 aaatcaatag agactataag acaagtgagt tttataaaaa ggtaagggat gactactata
    37741 catatagtaa agaaaatcct tatgcagacg taaatataac ttcatttata gaggaagttg
    37801 tatctgattt aaagcataat aatttgccat tgttagaaaa aattagaagt ataaaaaatt
    37861 catcttcaat aagtatatta cttggggttt taggtacgtt tgttggtctt tctacaatgc
    37921 ttttatgtgt tgatactaaa gacattataa attcacttcc ttcaactatt agtagtatgc
    37981 aaactgcatt tacaactagt atatttggag ttgtattttc tctaattata ggttatttta
    38041 ctaagataaa agattgtgaa catgttttga tacaaataat gttaaaatct gaaaatttac
    38101 taacatctga aataactcat tttaagtcag aaagaatgga tttaaaagta gaagaggtaa
    38161 aaaatacaat aaaacaaata agtaagtcta tagaagctat tgaaaaattt gataaaatat
    38221 ctaaagattt aaatgacttt aatgatgaat ttatcagtgg tatagaagct ttaaaaagcc
    38281 ttttagaagg ttctcaaagt tctattaaga catttgacca gagcgtaaga aaattagata
    38341 aacagtttaa tattttaaat ataaaatttg taaagctttt tgataaatat gataatcaag
    38401 ataatataaa taaagagatt ttatttgata taaaagaatc ttcaaaaaat atatacaatg
    38461 ccactgaaag ccaattcaaa attagagatt atataaaaaa tataaatgca ggatttgctc
    38521 tatatgaaag aagtgctcaa gatttattaa ctaaattaat gacccatgaa aataaaatct
    38581 ctcaaaatca aaaaatcctt ttagatgaaa agtttacctt agatgactca ataaaaaatc
    38641 tctcaagtat tattgaaaac ttttctaatg acctacaagt taaactggat atgatgtttg
    38701 aaaattcttt agatattcaa gataagttag atgttatgtt taataactct tttatgaatg
    38761 atgaagttcc tcttgatagt gaagaattat ttaaggatga tgttaataat gtatttaatc
    38821 cttttagtga agaaatttat gagatagagg ataaagaaat aaaggtcata ggtgaggatg
    38881 agttaaatga ataataaata tagaagaact gttaacagag aatttgaaaa gagtagcttt
    38941 tggccaacat ttacagattt attatctact gtattgatgg ttgtaattct tatcttattt
    39001 agctcagaaa gtatttcagg ttctgttgaa caagatttag ctaagaatgt caatgcttct
    39061 gttgaagaaa cttttaaaaa aagtggaata cctgtgaagg tagataaatc taatgggcaa
    39121 gtaacttttg gtgaaaaaac catgtttgat gtagatagtg atgttttaaa accagaggct
    39181 aaagaaatgc taaaaatgtt tgttccaaag tacatagaga ctatttataa agattatggt
    39241 gactatatat ccaaaatagt tatagaaggt catacagatg atgtgggaag ttatatatac
    39301 aacttagatt tatcgcaaag aagagcatat agcgttgcta aatttatagt gggagatgaa
    39361 ataggtgact ataaatacaa agataaagtg actaagcata ttattgcaat aggaaggtca
    39421 aaagctgaac tcatcaaaaa tggtgacaat agcgtgaata gagatgcatc tagaagagta
    39481 gaactaaaat acgaaataaa tattaatcaa aataaataat taaattttta taaaaaaaaa
    39541 gaaggcagtt ggtgtgagct ttaagccttc tttaaggaaa aagtttattt atttttgttg
    39601 atacttaaca tattatagtt tttagaagca gtttgcaata tattaaacgt aaatggtcgt
    39661 ttaaaatgca taactggata ctactgatgt aaaatatttc attttatata atataaaaat
    39721 tatacagtat caattttcta tattattgta ctataatcta ttatttaaaa tattatgtaa
    39781 aaaaatatca taaaaacgca tatcatgtta taattactag agtattatga atatggaggc
    39841 gtagtttgtg atagaaataa gtataaaaaa taaaaaaaat tctaaaatta aaactttgat
    39901 acttttattg atagtatcta tatcaattta tttaactggt tgtactacat tagataatgg
    39961 aaataatcaa tcaaataata atgattcttt gtctagtagt atatcaagtg ataagaatgt
    40021 aaaaattcat tttattgaca ctggaaatag tgatgcaata ttgattcaag atggtaaaac
    40081 ttttatattg atagatgggg gagataatga tgatgaggga ttaatggtag attacctaaa
    40141 caatcaaggt gtaaaagata ttaaatatct tatagctacc cattctcatg cagaccattt
    40201 aggtggactt gattctgttg tcaaaaactt taatatagaa aatgtttttg tatcgaatgg
    40261 ttcagcagaa acaaagagtt atagggactt tataaatgct ttagcaaata agggtttatc
    40321 cccaagtgta ccgcttgaaa ataataagtt ctatttagaa gattcttatt ttgaagttct
    40381 aaatacaaat gggggagata ctactaatga acaatctcta gtccttgtat atactaatgg
    40441 gaatgataaa gttttattta caggtgatgc tgaagaaggt accgaaaaag aaatactccc
    40501 taagcttgag aaagtagacc ttttaaaagt agctcatcat ggttctcgta gtagttcatc
    40561 tcaagagttt ttagataaag taaatcctga atatgcggtt cttttagtag gcaagggtaa
    40621 ttcatatggt catccacatc aggagacaat gaataaatta aaaaaaatgg gagtaaaagt
    40681 acatagaagt gatgagtgtt cagatataat atttgaatca acaggtgatg gagtatttac
    40741 aagttgtaaa gatggaagtt ataataaagg cgttagagaa gatggaaact ctggaaaatc
    40801 aaacagtaat acaagtaaaa atgattcttt taaaaataaa caaaatacat ccaattcaga
    40861 agaaatagtg tattttactc caaaaggtaa gagttatcac tctacaaaaa attgtagtgg
    40921 gctttcaaga agtaaaaaaa tattatcagg cacaattgca gaaagtaaga aaaatgaccc
    40981 atgtgatata tgttatggaa aataacaaaa aaacaaccaa tttatctata aagcttctga
    41041 actttaaatc atttaaaaaa taaaataaat gcataaaaaa ataagctata atcaatagat
    41101 aacacatttt atctatacga atagcttatt tttttaagta ttttttaata gctatttaat
    41161 aactctaaat acaccagtta caatacctac aatttcaact tctgagtcat tgagcataat
    41221 tggttccata aaatcatttt ctggctgaag tcttattaaa tttccttctt taaaaaacct
    41281 cttaactgta gcagattcac catttataag tgcaactact atctgagaat ttaaggctgt
    41341 attttttttg tctactacaa cgtaatcttc atctaaaatt cctgcattaa tcatactttc
    41401 gccttttact cttaatacaa aattgttact gccctttact aaactggcag ggaatggaat
    41461 gtattcctct atgttttgtt gagctaaaat gggttctcca gctgttattt gacctactaa
    41521 aggaagctct attatttctt gattagctcc agaaacatca tttactttac tacgttctaa
    41581 aacttcaata gctcttggtt tagtagggtc ctttcttatg tatcccagtt tttcaagttt
    41641 atttagatga gagtgcacag ttgaagtaga tcttaaccct acagcagtac atatttctct
    41701 tacagcaggt ggataacctt ttaatatgat ttgagacttt ataaattcca atatcaagac
    41761 ttgcttttca gttagatcta aatacataac atcactcatt tccatacact ttatattttt
    41821 aattataaca taatccattt atatctgcaa acatttgttc ctgattttta atcgtcctca
    41881 atccattcaa aattcttgac tatatcacgt tttacatttt tcttatgagc tgcataaagc
    41941 tgagtagttg tgacattatc atggtcaagt aagttttgaa catcatatat agaaaatcct
    42001 gtttggatta gagaagttgc agccgttgct cttaatttat ggggactata tccattgtct
    42061 ctagtagtat caagtggaat agatgtatat ttttttacca gtgttcttat agcctttgct
    42121 gtaattctct tattttgaag agacaaaaat aaagcatctt tttcttcatc atttaatagt
    42181 tcatctcttg ttctttcgtt ttgcaaataa tcttttatta catgttcaca agtatgattt
    42241 ataggcatta aaacttcttt cccacgtttt ctatatattt taaattcacc tcttgaaaaa
    42301 ttaaaagagg agatattgag ttctctaagc tcatttaatc taagcccgta tgtaacaaat
    42361 aatgctagta tagctttgtc acgtaattta gtttttctcc aatatacctt ttctttctct
    42421 gtaagccctt cacctgtttc tactgattca agcatcttag caacttcatc tatctcaagg
    42481 cgcttaatag catctggctg aggtttagga agttttattg gattgaatcc atcagttata
    42541 ttattatcta tctgagagtt tctgtataag aatttaaata gagtagagat ggatgatttt
    42601 tttcttgcta aagctctatt gttattttca aaaatcaatg tgtttttttc tgtatttttg
    42661 taatatctac tgcaataatc acctaagaat aaatttatat ctcttgattt tattgtatta
    42721 aaatcatctt ctgtaatatc ttttacacaa tctgcatttg ttaattcttt ggtttcaatc
    42781 aaatatgaac aaaaaaaatt aatatcttct aaataagcaa gtcgtgtaga aactgcaaca
    42841 gaacctttta aatatataaa ataatccttc ataaatacag gaagtttatt ttccaaaagt
    42901 agacattttt ctatgagttc attttctttg ataacaatat tatcaggttt atctgattta
    42961 ttatgtactt ttataatttt cttatcatta ttcaaaatta aacctcctaa aactaaaata
    43021 taaatctttt atattatttt ttgatattta taccaagtga gtataaatat ttaatttaat
    43081 cattttttac atttttaaga gattagcagt gctttagatg aaattatcac taactattcc
    43141 ctaaatccac atttaaagac tagttgaatt taagtactct tttttatttc tcaatatatt
    43201 tatagaaata ttttaaaata tattgagaaa ttttttatgc tctactaaaa tcttttttat
    43261 ataatatttt tatatgtttc taacgaaacc aaatattagt aaaatatgta tttatttaac
    43321 taaa
//
LOCUS       DAEPID010000030        42879 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.030, whole genome shotgun sequence.
ACCESSION   DAEPID010000030 DAEPID010000000
VERSION     DAEPID010000030.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 42879)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 42879)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..42879
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.030"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            complement(339..479)
                     /locus_tag="KR257_001772"
     CDS             complement(339..479)
                     /locus_tag="KR257_001772"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426234.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0030476.1"
                     /translation="MENLMMSIITGVIASYIYDKLKSHSERPTKSGWELNIKFQKSKS
                     SK"
     gene            complement(737..1897)
                     /locus_tag="KR257_001773"
     CDS             complement(737..1897)
                     /locus_tag="KR257_001773"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860809.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell wall-binding protein Cwp27"
                     /protein_id="HBH0030477.1"
                     /translation="MKLNKTLLAIGMSVSLLIASCPTSNALSSINSIKGTNKYETAGL
                     IADKQNYDIAILINSENGLSDGLSASGLSGAKNAPILLTKKDTIPSETLKRLEKVKEV
                     YLIGGKNSIGASVQKILSDKKISINRISGTDRIDTSHKVAKEIGSVSAVKKVILTNAF
                     KGEPDAMSVASIAVRDKSPIVLTDGNTTSFATDGLETYAIGGKVSISDKLINETKATR
                     IGGVDRYDTNKQIINKFYNGSKEFYIASGTDLVYSLVGSTIAQKTPIVLVGNGSNKSI
                     LKNASKITAIGNIDDVVIKQCLNITNNVGDSNTGIVKDTNSNNTNKPSNEPSSNNPGL
                     TDKSTVYVTPNGKSYHLTKNCSTLKRSKTINKVTLKQAKSQGKIDPCNVCVK"
     gene            complement(2068..2271)
                     /locus_tag="KR257_001774"
     CDS             complement(2068..2271)
                     /locus_tag="KR257_001774"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426228.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4236 domain-containing protein"
                     /protein_id="HBH0030478.1"
                     /translation="MGFNFRKSINLGGGLKLNLGKKSVGISAGVKGARVSVNSKGRKS
                     ATLSIPGTGISYTKTSTKKRKPK"
     gene            complement(2358..3392)
                     /locus_tag="KR257_001775"
     CDS             complement(2358..3392)
                     /locus_tag="KR257_001775"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426227.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YHYH domain-containing protein"
                     /protein_id="HBH0030479.1"
                     /translation="MFKKKLIAVAMSITMISVGSFSYAHSGRTDSSGGHRDNKNKSGL
                     GSYHYHCGGYPAHLHNNGGCPYTGGGSSSGTATSVNNEEKQKRSVGEKGYNQGYEDGY
                     KGNYSSSNYSGDYSDTYESKYSEGYEKGKAKLEEEEKEAKETGYNLGLTGAKSNNTYE
                     KEVLKNAYDTGYSTGYNEYKTKKIEEYKAKGIEDSNKDKEKMTFEENIDSKFIDAYNN
                     AYDEIQEQLKNDYTTQGFESAIKGERFDTSTIGNVKYANWFKEGYDNGKVKLPKAKES
                     VYNQGYNEEDFSIPDEMKSIETKLKGVYDEGLEKREEEKSRNATYGVGAGTAAVVAGV
                     VYKKKKRKKI"
     gene            complement(3914..5275)
                     /gene="rlmD"
                     /locus_tag="KR257_001776"
     CDS             complement(3914..5275)
                     /gene="rlmD"
                     /locus_tag="KR257_001776"
                     /EC_number="2.1.1.190"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003417358.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="23S rRNA (uracil(1939)-C(5))-methyltransferase
                     RlmD"
                     /protein_id="HBH0030480.1"
                     /translation="MSVKKKDVIEFEVDKMEFGGTSLSQVGDRVIHMKGGISGQKVRA
                     GVKKVRSKKAEVKMIELLENSPLETEETCKHFRECGGCTLLSVPYEKQLEIKEKQVMD
                     LFLKQDLFGFQFLGIEGSPENKYYRNKMEYTFGDEVKNGPLTLGLHKKGKHIDIQTVE
                     ECMLVDEDFSKILVSSVEFFNEKKLPYYRTMNHKGYLRHLVVRKGIHTNEIIVNIVTS
                     SQEDFDMYEFKDMLLGIDLKAELVGVLHTINDGLADAVQCDELRVLYGRDYIQEEILG
                     LKFKISPFSFFQTNTKGAEVLYSIARDFIGDYNDKVVFDLYSGTGSIGQVMAGAAKKV
                     YGIEIVEEAVVAANENAKLNGLTNCEFIAGDVAKVVKDLKDKPDLIIVDPPRPGIHKD
                     AIRDICGFGAKEIVYISCNPKSLVVDLVDFKGYGYEIKMVKCMDMFPNTPHCETVVKL
                     IRE"
     gene            complement(5302..6024)
                     /locus_tag="KR257_001777"
     CDS             complement(5302..6024)
                     /locus_tag="KR257_001777"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860778.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="rRNA pseudouridine synthase"
                     /protein_id="HBH0030481.1"
                     /translation="MAKKQRIDKILSNLGYGSRSEIKKYCKQGSVVVNGSEVSNPGTQ
                     VDTENDEILFNGEEVIYREYIYLMMNKPDGYISATTDKYDPTVLDLIDLSYLAFEPFP
                     VGRLDKDTEGLLVLTNDGKLSHRVLSPKKHVPKTYYAKIDGVVTEEDVEAFLEGVVLD
                     DGYKTMPSQLNILKSDDESEIELTIHEGKFHQVKRMFESVGKKVVYLKRLSMGNLKLD
                     ESLELGEYRELTDEEVKLIEER"
     gene            complement(6024..6353)
                     /locus_tag="KR257_001778"
     CDS             complement(6024..6353)
                     /locus_tag="KR257_001778"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003417354.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1904 domain-containing protein"
                     /protein_id="HBH0030482.1"
                     /translation="MPQIKIRGINENDICKISEKMINDLVEAVKCPRDYFEIECIKSV
                     AIRDGKIADVYPFVEVAWFDRGQEVQDIVARIITDSIRNNLDVESMDLAFTVFEKEKY
                     YENGEHF"
     gene            6683..7609
                     /gene="fba"
                     /locus_tag="KR257_001779"
     CDS             6683..7609
                     /gene="fba"
                     /locus_tag="KR257_001779"
                     /EC_number="4.1.2.13"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860777.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="class II fructose-1,6-bisphosphate aldolase"
                     /protein_id="HBH0030483.1"
                     /translation="MALITTKEMFKKAYEGGFAIGAFNISDLEQLQGVLKAAKAKNSY
                     VMIQASMSAVKYAGPHTLVEMVKAASDEIGVDVALHLDHGPNMDAIKTCIDAGFSSVM
                     IDGSHFDFEENVRITKEAVEYAHSKGVVVEAELGVLAGTEDDVTSDVHKYTQPAEAVE
                     FVERTGVDSLAIAIGTSHGAFKFKGEAKLRFDILEEIQSKLPGFPIVLHGASAVDQNA
                     VATCNEFGGNIAGAKGVPVDMLRKASSMAVCKINMDTDLRLAMTAAIRKFLAENPKEF
                     DPRKYIGAGRDAIQAVVESKIDDVLGSANSIN"
     gene            complement(7744..9375)
                     /locus_tag="KR257_001780"
     CDS             complement(7744..9375)
                     /locus_tag="KR257_001780"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434571.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sigma 54-interacting transcriptional regulator"
                     /protein_id="HBH0030484.1"
                     /translation="MDNNLIGLIEHVENPAILCKESGEIIYCNHLIDSIFSFLDIKKP
                     RNINELDSNFDKTEILTDSKKKIAFRELRMTAHIYNMKDNNNENNIVYLFEKSLISDK
                     VIEDIIEHIDEVVVVFNKDGVIEKMNTVSDEILPFKRTEVLGRNITDLVRQGLVEEPI
                     ILNMLKVKKKIYRNIVYPDGKLIAYTAVPRWDSKGKLTGGVLTGRDISRVIKLESQIK
                     YSDISEDTEYISQSKIMDNIKKVVKRAAASDSSIFINGESGVGKEIIARTIYKYSSRR
                     DKPFIAINCGAIPNELLESEFFGYEEGSFTGAKKKGKKGLFEEANGGTIFLDEIGELP
                     MQMQKKLLRVIQENTITRIGGSKPIKIDVRYISATNISHEDLRNNLKFRQDLYYRLSV
                     IPVKIPPLRERKEDIVPLVNYFLKLYNEKYNREVEVSPKVIELLEEYSWPGNIRELKN
                     IIERFVVLSAKNVIGEDEFNMLINLDMIDNETDDLSPIVVNGIMNLNDAYKIVDQIMI
                     SKAINKYGSITKAAEVIGIYPSTIHRKIKSGHIHV"
     gene            complement(9858..10895)
                     /locus_tag="KR257_001781"
     CDS             complement(9858..10895)
                     /locus_tag="KR257_001781"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003417347.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="electron transfer flavoprotein subunit
                     alpha/FixB family protein"
                     /protein_id="HBH0030485.1"
                     /translation="MNDIKDLSSYKNVWIFAEQREGKIAPVVIELLGEGRKLAKEVDA
                     ELCAILLGKDVDGLAKELITFGADKVYVADDALLEKYTTDAYTKVIKDAIDEIKPEIM
                     LFGATHIGRDLAPRIASRVGTGLTADCTKLEIDPEDKKIKQTRPAFGGNIMATIICPN
                     HRPQMSTVRPGVMDKAEKDETRTGEVIALDYKITQDDIRTTVLETVKTKKDLVSLTDA
                     NVIVSGGLGLGGPEGFEMLKKLADKLGGVVGSSRAAVDAGWIDHSHQVGQTGTTVKPN
                     LYIACGISGAIQHLAGMQSSDFIIAINKNPAAPILEIADYGVVGDLHEIVPMLIEKLD
                     SVDDLLEAIKA"
     gene            complement(10914..11699)
                     /locus_tag="KR257_001782"
     CDS             complement(10914..11699)
                     /locus_tag="KR257_001782"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012703997.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="electron transfer flavoprotein subunit beta/FixA
                     family protein"
                     /protein_id="HBH0030486.1"
                     /translation="MKILVCVKQVPDTNEVRINKETGTLIRDGVPSILNPDDANALEE
                     ALKIKDEHDDVTITVITMGPPQADFMLRECLAMGADDAILLSDRAFGGADTWATSNTI
                     AAGISKVGDYDIIFAGRQAIDGDTAQVGPQIAEKLDIPQVTYVQDFKIEGKDIIVQRQ
                     LEDGYELIKVSTPVLLTAVKELNTPRYMSVDKIVKAYKHDVKVWTIDDLDVNKEEVGL
                     KASPTKVFRSFTPEPRGKGEILEGKADEIASKIIIGLKQKHII"
     gene            complement(11732..12865)
                     /locus_tag="KR257_001783"
     CDS             complement(11732..12865)
                     /locus_tag="KR257_001783"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003483287.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="acyl-CoA dehydrogenase family protein"
                     /protein_id="HBH0030487.1"
                     /translation="MLYNKEQELLRKAVRDFVSKELDTLPAEMDKTGVMPKELIKKLA
                     DAKFISSNIPEEYGGGGAGYVSYAIVMEEIARRCASTATFVTAGSSLASLPILYNGTE
                     EQKQKYLKGIATGELIGAFGLTEPGAGSDAGGQQTTAELVGDHYILNGRKTFITNGPF
                     CDVAIVIAVTDRSKGLRGTSAFIVESKWDGFSTGAHEDKMGIRGTETSDLIFENVKVP
                     KENLLGKEGQGFKIAMGTLEVGRIGVAALALGIAQGALDEAVKYTKQRVQFGKPIAKF
                     QNTQFTIADMETKVCAARGLVYDAAQKRDAGMRVAQESAMAKYYASEIANEVAYKALQ
                     LHGGYGFIKDYEIERMYRDARIVSIYEGTSEVQKMVISSNVLK"
     gene            complement(12913..14040)
                     /gene="hadC"
                     /locus_tag="KR257_001784"
     CDS             complement(12913..14040)
                     /gene="hadC"
                     /locus_tag="KR257_001784"
                     /EC_number="4.2.1.157"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003427763.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="(R)-2-hydroxyisocaproyl-CoA dehydratase subunit
                     beta"
                     /protein_id="HBH0030488.1"
                     /translation="MEAILSKMKEVVENPNAAVKKYKSETGKKAIGCFPVYCPEEIIH
                     AAGMLPVGIWGGQTELDLAKQYFPAFACSIMQSCLEYGLKGAYDELSGVIIPGMCDTL
                     ICLGQNWKSAVPHIKYISLVHPQNRKLEAGVKYLISEYKGVKRELEEICGYEIEEAKI
                     HESIEVYNEHRKTMRDFVEVAYKHSNTIKPSIRSLVIKSGFFMRKEEHTELVKDLIAK
                     LNAMPEEVCSGKKVLLTGILADSKDILDILEDNNISVVADDLAQETRQFRTDVPAGDD
                     ALERLARQWSNIEGCSLAYDPKKKRGSLIVDEVKKKDIDGVIFCMMKFCDPEEYDYPL
                     VRKDIEDSGIPTLYVEIDQQTQNNEQARTRIQTFAEMMSLA"
     gene            complement(14040..15266)
                     /gene="hadB"
                     /locus_tag="KR257_001785"
     CDS             complement(14040..15266)
                     /gene="hadB"
                     /locus_tag="KR257_001785"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888224.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="(R)-2-hydroxyisocaproyl-CoA dehydratase subunit
                     HadB"
                     /protein_id="HBH0030489.1"
                     /translation="MSEKKEARVVINDLLAEQYANAFKAKEEGRPVGWSTSVFPQELA
                     EVFDLNVLYPENQAAGVAAKKGSLELCEIAESKGYSIDLCAYARTNFGLLENGGCEAL
                     DMPAPDFLLCCNNICNQVIKWYENISRELDIPLIMIDTTFNNEDEVTQSRIDYIKAQF
                     EEAIKQLEIISGKKFDPKKFEEVMKISAENGRLWKYSMSLPADSSPSPMNGFDLFTYM
                     AVIVCARGKKETTEAFKLLIEELEDNMKTGKSSFRGEEKYRIMMEGIPCWPYIGYKMK
                     TLAKFGVNMTGSVYPHAWALQYEVNDLDGMAVAYSTMFNNVNLDRMTKYRVDSLVEGK
                     CDGAFYHMNRSCKLMSLIQYEMQRRAAEETGLPYAGFDGDQADPRAFTNAQFETRIQG
                     LVEVMEERKKLNRGEI"
     gene            complement(15281..16081)
                     /gene="hadI"
                     /locus_tag="KR257_001786"
     CDS             complement(15281..16081)
                     /gene="hadI"
                     /locus_tag="KR257_001786"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888223.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="2-hydroxyisocaproyl-CoA dehydratase activator
                     HadI"
                     /protein_id="HBH0030490.1"
                     /translation="MYTMGLDIGSTASKGVILKNGEDIVASETISSGTGTTGPSRVLE
                     KLYGKTGLAREDIKKVVVTGYGRMNYSDADKQISELSCHARGVNFIIPETRTIIDIGG
                     QDAKVLKLDNNGRLLNFLMNDKCAAGTGRFLDVMAKIIEVDVSELGSISMNSQNEVSI
                     SSTCTVFAESEVISHLSENAKIEDIVAGIHTSVAKRVSSLVKRIGVQRNVVMVGGVAR
                     NSGIVRAMAREINTEIIVPDIPQLTGALGAALYAFDEAKESQKEVKNI"
     gene            complement(16120..17319)
                     /gene="hadA"
                     /locus_tag="KR257_001787"
     CDS             complement(16120..17319)
                     /gene="hadA"
                     /locus_tag="KR257_001787"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003427766.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="isocaprenoyl-CoA:2-hydroxyisocaproate
                     CoA-transferase HadA"
                     /protein_id="HBH0030491.1"
                     /translation="MLLEGVKVVELSSFIAAPCCAKMLGDWGAEVIKIEPIEGDGIRV
                     MGGTFKSPASDDENPMFELENGNKKGVSINVKSKEGVEILHKLLSEADIFVTNVRVQA
                     LEKMGIAYDQIKDKYPGLIFSQILGYGEKGPLKDKPGFDYTAYFARGGVSQSVMEKGT
                     SPANTAAGFGDHYAGLALAAGSLAALHKKAQTGKGERVTVSLFHTAIYGMGTMITTAQ
                     YGNEMPLSRENPNSPLMTTYKCKDGRWIQLALIQYNKWLGKFCKVINREYILEDDRYN
                     NIDSMVNHVEDLVKIVGEAMLEKTLDEWSALLEEADLPFEKIQSCEDLLDDEQAWAND
                     FLFKKTYDSGNTGVLVNTPVMFRNEGIKEYTPAPKVGQHTVEVLKSLGYDEEKINNFK
                     DSKVVRY"
     gene            17996..18994
                     /locus_tag="KR257_001788"
     CDS             17996..18994
                     /locus_tag="KR257_001788"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003431407.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="D-2-hydroxyacid dehydrogenase"
                     /protein_id="HBH0030492.1"
                     /translation="MKILVFGARDYEEPVIKKWSEEHKDVQVDIYPENMTEENVVKAK
                     GYDGISIQQTNYIDNPYIYETLKDAGVKVIASRTAGVDMIHFDLVNENGLIVTNVPSY
                     SPNAIAELAVTQAMNLLRKTPLVKKKVCEGDYRWIAELLGTEVRSITVGVIGTGKIGA
                     TSAKLFKGLGANVIAFDQYPNSDLNDILTYKDSLEDLLKEADLITLHTPLLEGTKHMI
                     NKDTLAIMKDGAYIVNTGRGGLINTGDLIEALESGKIRAAALDTFETEGLFLNKKMNP
                     GELTDPEINKLLSMEQVIFTHHLGFFTSTAIENIVYSSLSSAVEVIKTGTATNRVN"
     gene            19356..19883
                     /locus_tag="KR257_001789"
     CDS             19356..19883
                     /locus_tag="KR257_001789"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003417338.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TIGR04002 family protein"
                     /protein_id="HBH0030493.1"
                     /translation="MEKMNKVTSKKTTYIVTSALFASIICLTIAYILHIPVGGNNGYV
                     HIGDAFIYLAATILPTNYAIAASAIGAGLADLSTGAAIWVIPTIIIKPILVLFFTSKS
                     DKIINKRNIVASVVAGIVGLVLYMFAEGIIIGSFTSAFVMSLLGLLQPIGSFIVFIIL
                     GMALDKLDFKKRYFN"
     gene            19910..20506
                     /locus_tag="KR257_001790"
     CDS             19910..20506
                     /locus_tag="KR257_001790"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434869.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TIGR04100 family radical SAM protein"
                     /protein_id="HBH0030494.1"
                     /translation="MNILYTIENSIYVNITNTCPCSCVFCIRNEKDEVANSGSLWLEH
                     EPSVDEVKEAFNKYNLDDYDEIVFCGYGEPLMRINELIEVAKFIKEKSSIKIRINTNG
                     LSDLIHNKKTAILLKNVIDAVSISLNAPNKEAYNRVTQPKFGEKSFDYMLDFARDCKK
                     YIKEVAFSVVDEISPEEIEESKQLAKKLDIPLRVRHKN"
     gene            complement(20571..22154)
                     /gene="asnB"
                     /locus_tag="KR257_001791"
     CDS             complement(20571..22154)
                     /gene="asnB"
                     /locus_tag="KR257_001791"
                     /EC_number="6.3.5.4"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003417334.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="asparagine synthase (glutamine-hydrolyzing)"
                     /protein_id="HBH0030495.1"
                     /translation="MINLEEKYLTRKDTYMIKILEYNGHIRNWKVLCEELGIDSSLCR
                     DERERAILVEAYKTWGYDMANHMHGMFAFALWDTVEKKLFCLRDQFGVKPFYYYETEN
                     GKLLYGSSIRKIMEQPGFVKELNEDMLQIYMSFTYVAGENTFFRGVKKLMPGHYLVYQ
                     NKTVCIGRYWKPEFHPDHSKSIEEWTDEIHTTLQKIMPEVKSENETAELFLSGGVDSS
                     YILAMSDIEKTGSCGYEEERFDESKLAQQTANILGCKNSRYIITPEEYFASVPYVMYH
                     MEQPTGDASAIVFAIGCKAAAENTNICYSGEGADEFFGGYNIYHKAECYGENLKTFYI
                     GNTNIMNEGEKRKILKKYNPDVLPIEVVKGIYEETEELDTLTNMSNVDIQIWLEGDIY
                     FNIDKMSTAVGLEVRMPLTDTRIFDIASRIPSEYKVKGKENKIAFRTAASKTLPEEIA
                     FRNKLGFIVPIRIWMADDQYNKDIRDKFNSEIADKFFNIDEINEIFNDYISGNSDNWR
                     KIWMIYTFLVWYEIYFVKC"
     gene            complement(22720..23556)
                     /locus_tag="KR257_001792"
     CDS             complement(22720..23556)
                     /locus_tag="KR257_001792"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434860.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PRD domain-containing protein"
                     /protein_id="HBH0030496.1"
                     /translation="MNYIIKKVLNSSVVLVHDTKDNEFILLGKGIGYGKKTGEYICGS
                     NDNQMFVPVENTKSKQFLELMDDIPVDILKITQEIIVEAEKLLNSSFNKNLYLILADH
                     FNFAIERMRKGIKITNRVFWEIKNYYPNEFKVGMVAIYMVEERLGIQLPEEEAANIAF
                     HFANAMASDGNSYDTIKYAKVIGEIINIFVFSLNRTLDKKSMHYMRFITHIKFFVERF
                     FSDSMLSSGDDLLFNQMKRSNPKEMLIALKVRDFLEKKYGKKLTNEEIAFLVVHIARV
                     KQ"
     gene            complement(23580..25046)
                     /locus_tag="KR257_001793"
     CDS             complement(23580..25046)
                     /locus_tag="KR257_001793"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000110363.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="family 1 glycosylhydrolase"
                     /protein_id="HBH0030497.1"
                     /translation="MRKFPEGFLWGGATAANQFEGGWNLGGKGWSVSDVAKAHFDADV
                     KDYKSNNEITTKDIEEGLAHPEDEVNYPKRHGSDFYHHYKEDIALMAEMGFKTYRMSI
                     AWSRIFPNGDDKEPNEEGLQFYDDVFDELISYGIEPLVTMSHYEPPLNIVLNYDGWYS
                     RQVINMFVRYVETICERYKNKVKYWLTFNEVDSMIRHPYTTGGLVRDRFKDKNFEEVI
                     FQAMHHQFVASALATKICHEIIPNSKVGCMLTKLTYYPYTCRPEDVLATQRKMRSIYA
                     YSDTQVFGEYPVYLLSYFKNNNIQIVKEEHDDEIMKKYPVDFISFSYYMSSCEAADTT
                     GLDITPGNTLLAVKNPYLEMSEWGWQIDSIGLRISLIELYDRYRKPLFIVENGLGAKD
                     ILTEDKKVHDQYRINYLKEHFKCMLDAIIEDGVELWGYTSWGCIDLVSESTKQMSKRY
                     GYIYVDADDYGKGTYNRYKKDSFYWYKKVIESNSIDFK"
     gene            complement(25049..26911)
                     /locus_tag="KR257_001794"
     CDS             complement(25049..26911)
                     /locus_tag="KR257_001794"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728580.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS glucose transporter subunit IIA"
                     /protein_id="HBH0030498.1"
                     /translation="MNYKKTAIDIIEQVGGSKNILALEHCSTRLRFKLIDRSKVNQDA
                     LKKVQGVMSIVNGAQFQVVIGNSVVDVYDEILKVCPLDTNDSTVKTEEKINLGTRFIE
                     FIINIFQPLIFAIAGAGILKSLLMLLAMFNILKSDSTIYTLLVAISDATFYFLPLMVA
                     VTTANVLKCNRLVAIAAVGYLLLPATTTALSEGVELFGFTIPNIAYNAQVFPAILCVS
                     FLATMEKIFNKYSPKPIRTFFVPMMSLAITVPITLTILGPLGYNVGTIFTTIILFLYN
                     KMGFLVVGLLAAFLPFMVATGMHKALIPYSINTIGKLGYEALYMTSSLAHNISESGAC
                     FAVALRTKDETLKQTALSAGISALMGITEPALYGITLQHKRAMLGVVFSSAISGTFLG
                     LFAVKGFVIVGPGLASMSMFIDPNNGNNLIFASIGFVIAILGSFIITLIIWKEDTNTV
                     ESSIGDVVEEELEEEKEVNILVTPVEGKVIDLSKVNDELFASKTLGDGVAIIPTNGNL
                     YAPCDSEVVMLFETKHAIGLRTKNGAEILIHIGINTVSMNGDGFKTFVKTGDNVKEGD
                     LLIQFDLDKISHANLDSTVMIVNNNGADYAYKVLNQSYGNVKKGSILFDVKGGI"
     gene            complement(27158..28021)
                     /locus_tag="KR257_001795"
     CDS             complement(27158..28021)
                     /locus_tag="KR257_001795"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003431420.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="EamA family transporter"
                     /protein_id="HBH0030499.1"
                     /translation="MILSYFALLIRVVLLAFERVVVRLLGDEEGDIYKNIASSFLFFF
                     IGGVCLLPFSIMDRVSDWSFLIPCYISSLVYSIGSVAYVTSLATGEVSLVTPINSLNS
                     LFLLLLSVIFLGEGLSLAKVAGIIIMIGGVFILKKVSSFLKNVSVIFNNLPCRLMFLY
                     IFLQSVGRVLDKAFFVQVSPILYSTILYFFVGLNLFIFLAFKKKQKIICEIFSNKKGL
                     SILSGAINGYSYLALLIALNNLELSIAEPFSQVSMIITLILAHFIFKENIKEKIPGSI
                     LILIGGWLLLL"
     gene            complement(28076..29008)
                     /locus_tag="KR257_001796"
     CDS             complement(28076..29008)
                     /locus_tag="KR257_001796"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728579.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="D-aminoacyl-tRNA deacylase"
                     /protein_id="HBH0030500.1"
                     /translation="MNNKKAVFFFCSDLKKDPVASNVIKCCEEIMDLNQTDIVIDDNF
                     VLEFKDKNNNLFHFVKTKDVISHNYKYYLPILNRHFRDYDFAGVVNWHEGENAPEHIL
                     TAHTIGDVPTGEFGNSNPRYFKNLINAIEDIKNENLLDEFTTLTEATHWSGTTYGEES
                     KLITEYSVPMLDIEIGSSSDSFNNSIAIQVLAKSLIRVFDCDEPLKTLLCVGGVHFEK
                     SFSDIIKNKEYNISIGHVLPNQWIVSGMYDDESGFEKLEKCINSIEGGIDCIVFHDKL
                     KGTYKEQCRKLGEKLNVPVFKHKILKNPKDLPIW"
     gene            complement(29094..29645)
                     /locus_tag="KR257_001797"
     CDS             complement(29094..29645)
                     /locus_tag="KR257_001797"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003427786.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="HBH0030501.1"
                     /translation="MQSLNEIIAENLKKIRKEKHLSLDKIAQLSGVSKSMLSQIEKCE
                     VNPTISTLKKITNGLKISFTSLMERQESDIELIQKSDIDHFIEDNGKYISYPIFPFDS
                     KRRFEIFMIEIEEGGNLDSNAELPGTQEFITVFSGEVTIKINGEDYIVSSGNSIRFKA
                     DVSHIYRNSGKGIAKMSMVVYYI"
     gene            complement(29874..30365)
                     /locus_tag="KR257_001798"
     CDS             complement(29874..30365)
                     /locus_tag="KR257_001798"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003417320.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0030502.1"
                     /translation="MIDLKIENRKGKIHVKSSEIKDILELRPDFEYVQDISNTINQEN
                     ILVFDCQLTGNSFDMDDLDIEEILEELGEEIDESYFSVLFEDVRAYLKDATDEIEADL
                     QDNYLFDNLRCYFDIYNINQEFTDFKFVFLVSFKDIKISSLANLAKIVSKRQLIGASK
                     FYS"
     gene            complement(30393..30953)
                     /locus_tag="KR257_001799"
     CDS             complement(30393..30953)
                     /locus_tag="KR257_001799"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009904860.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hydrolase"
                     /protein_id="HBH0030503.1"
                     /translation="MNKLNICIDIDGTITSPYHFLPYLNDIFNKNITEAECITHNWEE
                     LYGSGIRDVYAEFNNKYIHSYDEAKIVEGATEVISTLSKGHNLSFVTARHECLTDVTK
                     NWLSRQGFSDIDVYLLGSDYKVEKARELSCDIFIEDNPLNSVQLADDGVKVILLDTNY
                     NKDVKHQNIVRVSNWIDIEKIIKQGI"
     gene            complement(31105..32262)
                     /locus_tag="KR257_001800"
     CDS             complement(31105..32262)
                     /locus_tag="KR257_001800"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728578.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SAM-dependent methyltransferase"
                     /protein_id="HBH0030504.1"
                     /translation="MNKQSIGKLNMFFMGITQRNLDNRDFFIELEVIFKSGRKEFKGI
                     AIEEDNKYKFNFKGKSDLYTFNELLKNISKEAENYDGLVFKYVERGTIVVIEGDNKKV
                     NVKYLDNKEEVPKIDEFTASQIKNRDYYVKVGQANALLKEIGVLTKDGKIKNDKIRKY
                     NQIDHFVELIDSILKEIKDKDCITILDCACGKSYLSFVLNFYIKEVLKKNCYFIGIDY
                     SDVVIEASKNMAKNLGYKNMSFIKEDLTNYTPNRDVDLVISLHACDTATDMAIGLGIR
                     AKSEAIVVVPCCHKELLGQYRYEAMEPILKHGVFKARFADLITDGLRTLLLEGNGYDT
                     SVVEYISPLDTPKNLMIRAIKTKTNNDKALKEYKELKSQFGVEPTLEKLIY"
     gene            complement(32299..33240)
                     /locus_tag="KR257_001801"
     CDS             complement(32299..33240)
                     /locus_tag="KR257_001801"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888206.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0030505.1"
                     /translation="MRWILVFIFLYLIPLVVIFRNYKNFKRSCIYSSIYVVLATTIMI
                     SNIYMSGLNKIKESMYYHNYISDETYDEKYVSNFKEKESTDLNQDNKKNEEISNNKNL
                     NNKQDRNIQNKESNEEGSNDIKEKNNSDSNVSVNNKSEKQEDNTKENNKYTSKEKNSE
                     DIKKIDMESIGIFKKEIYNIERAALVPMRECIPYTKDIAKNITKLSSIKKDVTNARNK
                     CKEVVKEYENMQIPELSKEKYTETLSNARDDVKKAYELREKSMESALKLINTKSPKYI
                     GKITEYLDLSDKQIESFKNRLNDLKEEINNSETNNIN"
     gene            complement(33327..34019)
                     /locus_tag="KR257_001802"
     CDS             complement(33327..34019)
                     /locus_tag="KR257_001802"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003417312.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="metallophosphoesterase"
                     /protein_id="HBH0030506.1"
                     /translation="MSLYAIGDLHFSTSVNKPMNIFGSNWDGHEKKIIDNWKEVVKEE
                     DMVLVLGDTSWGINLSEAKKDLDIISKLPGQKILIKGNHDYWWTTVTSLNKLYEDMRF
                     IQTNFYEYKDYAICGGRGWICPNDVKFDETDEKVYKREEHRLRLSLESARKSGHSKII
                     VITHYPPTNDKLEESLFTKLFEEYNVEKVIYGHLHGKESFKMGLKGIRNGVEYTLASC
                     DYTEFNLIKVHD"
     gene            complement(34128..34940)
                     /locus_tag="KR257_001803"
     CDS             complement(34128..34940)
                     /locus_tag="KR257_001803"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003417310.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GTP pyrophosphokinase family protein"
                     /protein_id="HBH0030507.1"
                     /translation="MEYEKWNEILAPYEHAVEELKIKFKNIRKEYLAKGEYSPIEFVT
                     GRTKKISSIISKLKRINAKDIETEIDDIAGIRIMCQFVEDIYAIVDLIKVRNDMTIIG
                     EKDYITNYKDSGYRSYHVIIKYPINSIAGSKEIICEIQIRTLAMNFWATIEHSLKYKY
                     DHYIPETLAERLRRASDAAFLLDQEMSEIREDIMKAQAMYQMKSIAIRDTLNRIQELY
                     DLGDTHKAMQYQRKLDRTETDKNITEILELKQEIDILLEQYKDTKVDDKVVQ"
     gene            complement(34991..35902)
                     /locus_tag="KR257_001804"
     CDS             complement(34991..35902)
                     /locus_tag="KR257_001804"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009901790.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MBL fold metallo-hydrolase"
                     /protein_id="HBH0030508.1"
                     /translation="MNLTKVKGNTFFIKGGTNTGIYVFEDNTALMIDPGLCGSRPRRV
                     NKVLDENNIQVRYIINTHGHDDHYGACNQFKEYYKDVCIMSSEYDKLYIENPELFSKY
                     IVGGKSNVFMDNILKNKMLDDIKIDKFIEAGKFELNNEMFDIIEFQGHTPGSIAVLTK
                     DNVIFVGDLLIGDEILSKYDFLFLYDIQEQINSLEKLKNIDFEYLVLGHGKQVISKED
                     SYKLIEKHLNALKKYLYQIRELLVEPKSLEILLKNIINNNNLSNNYKEYHFFKSSLVS
                     VISYLVDLEEIGYILENGELLYYTKTK"
     gene            complement(35961..36692)
                     /locus_tag="KR257_001805"
     CDS             complement(35961..36692)
                     /locus_tag="KR257_001805"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434835.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YkgJ family cysteine cluster protein"
                     /protein_id="HBH0030509.1"
                     /translation="MTSIKNKDILNCIDYSIKNKLFDKLNDVYKSLPVGNCSGCGNCC
                     MESVGINLIEFLNIFCYLEDRVDLKKSCISKILDYYFEEYTRKNPCPFKDTNNRCLIY
                     EVRPLNCRMFGHWKKEDYNKNLDNVIEKNNNYRELMKKQYGFEINDEVVNYRIDYCDR
                     FIPNKDYLSKSKRLSFFDELMILDSNIYSSGNIDIDFRDRGIVEYFIESLLYRNLAYN
                     VKIRISKEYKIRKRTIDRIKRIVLV"
     gene            36781..37032
                     /locus_tag="KR257_001806"
     CDS             36781..37032
                     /locus_tag="KR257_001806"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003417301.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0030510.1"
                     /translation="MNRYTKIINMMGSYYTKDFEKEKKNVIKVREVKEDTVRKFFLQG
                     DCEVLVVFEDTGKEILIDDFSPEEDIKKYLGAKFINKKR"
     gene            37266..37685
                     /locus_tag="KR257_001807"
     CDS             37266..37685
                     /locus_tag="KR257_001807"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003417291.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0030511.1"
                     /translation="MQIYFRVKAVGKRKPMLELTPFDVSDNINCLKEAISEIVSKNVL
                     EYNEKIPEKSIINFLTNEEIESQADIGKVGFGSIYNENKQSVEKAIEVALQAFEDGIY
                     KVLINEDVIEKLDSSINLKSGDIFTFIRLTLLAGRMF"
     gene            37710..42767
                     /locus_tag="KR257_001808"
     CDS             37710..42767
                     /locus_tag="KR257_001808"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003417287.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4132 domain-containing protein"
                     /protein_id="HBH0030512.1"
                     /translation="MLERTRVEKNPKIIENFKNNFTKSSSKQYYDLAKSLWDCIENSS
                     YYYREPEDKFLNMIKKYYNCHYYEIKNMDELLSGPLKNALELIFTSEQVEELCQLIKR
                     KMDYTYSGGYYRKGYRSNKLVDYFRGIIRFISNYVDLIYYDFSVIDYLTLPNKVLYYD
                     SIMSDKIALEIDKGNQKVISALEEVIFGENQTALLTRQMIIGIMKSHSDKCYEMLSKL
                     LLAAKQQEGLRQQIVESLDEGTISASIYMLKTILDNNLERFSSVIRALDTWTGLGFSD
                     QKPGIIRKCLELSYKSLTDEKFRIESINSNDNLEIYFALWATATYNIYDSYSLIENLL
                     SCQEKYKKLVALYFLSHTESTYFKHSIASKNIKGDDLEILAWVITNFYVEGSVGYYYS
                     WQNRETNFDLSNTPIDKDFDARKEQFESLKHTLEILNSKTKSFSGSVFPWTWIEISSH
                     EILKCMMTLTAYDMNAQFIDVLMENCHLMSSDLRASLIVNFVNEPKTDRQREFLLECL
                     SDKSVSNRETVLSLLRKLELTDVELDKITNLLSLKTSSIRQTVIKILLEQDDSNLENI
                     ASSLIKSSNSQKCLGGLEIVNLLKDNTARQELYNKLVLLIEDIDKSKKNTSQVQILID
                     NLLGKAKNDYCKENGFGIYNPENKVQIPEQFDFKDDSNSSSKLNKIISNISLSTREDS
                     VSVATKKEAKKILDTDINKIIKVYEKFDELITENADYEYEVERWSGNVDKVLLGYSTY
                     NLTPIKYKVSNDTLDNYPLAELWRETSKKLDLDYKLILDILFYSISTCGYNETEKSWF
                     SSIYSNVLDSKKQNKIYTKLEKLKFNGLTRKLLRVLLNEFDHKEIFNYCLEIYYKLRN
                     LLTIEQCKKQRVEFTKNYYRQNEYCPALNAPILNYWLDKAHSFIYDDISFTKFFYTTF
                     SNYQLLEYKFPFYTSINVFARAHELGLMTEEQVNREMISGYNASNIIRTLTNPRWAGD
                     TLEKYPWLKDNLKTVTNRIIEIESRRGDMPTEVSHLANNIQYFEGINYFVNILVALGK
                     ETFQRGYSYGSNYSKKDVLSSLLKNCYPTKEDDSKKLKSLLKNTDITELRLIESAMYA
                     PQWVNIIEKYLNWKGLKSTIWYFHAHINEGFSAQKESEVALFSPISPRSFIDGAFDVD
                     WFLDSYKTIGEERFNILYKSAKYITSGGNSHRRAQLYADATLGKLDKDMLMKEIETNR
                     NQDKLRSFSLLPMKKGDLKEATFRYEFIQKFAKESKQFGAQRRESESKACTIALENLA
                     RSAGFGDVNRMMWALETEKLNEVAHLFKPKDIDGTSIWIDVDENGKASTKVQKGNKSL
                     KSIPKAIAKHPYVLELKSVQKDLKSQYSRAKQSLEQAMKNEIVFTVKEIANIYKNPVI
                     CPLIKNLVWVCDDNIGYVYNDKSKFFICNIEGETYKLTAKNKLKLAHPVHLFESGKWS
                     EFQHDLFSKQIVQPFKQVFREYYRINSDELSEKTISRRYAGHQIQPKKTVALLRNQLW
                     TVDYEEGLQKVFYKENIVAKMFALADWFSPADIEPPTIETVEFFDRKTYKSLELASIP
                     PILFSEVMRDIDLVVSVAHAGGVDPETSHSTVEMRIAIAKELLLLLKINNVNFEGSHA
                     LIAGNLGEYSVHMGSGIVHKKGMGALNILPIHSQSRGKIFLPFADEDPKTAEIMSKIL
                     LLAEDSKIKDPSILSNL"
BASE COUNT        14051 a         7425 c         5017 g        16386 t
ORIGIN      
        1 cagtttttta tccacttttc taatgaagtt attttttcat atgttaattc ctcttgaaat
       61 aatgatacta aaagactttt tataaaatta taacttaaaa gtttatgtat ttttttgata
      121 tgaatttata gtacttatct tctttaattg agattgtgta tatttaacta aacattacaa
      181 caataattct atgaaatcaa atcaattatt tacatatttt tttagaacaa taataagtat
      241 atattcacaa aattttgtgt taatattttt aatttgtgat ataataaaag caaggaaaca
      301 tattttactt aactttgagt gatgtttcct tcaacaaatt attttgaaga tttacttttc
      361 tggaacttta tattaagttc ccagccactc ttagttggtc gctcagagtg gctctttaat
      421 ttatcgtaaa tgtaactggc tataacacca gttataatac tcatcattag attttccata
      481 gttttcacct cctctcataa gaaagtgaag aaacttccat ggaaacacca ctcatagctt
      541 tttcaaatat ttattccttg ccatattaat tatatcataa atattggaaa cataaaattt
      601 taatacttat cgtctttatt attatttttt ataattaata atttttttta ataatacata
      661 atataaattt atatttcttc aataaaaaag acaatcttaa ttaattgtct tttttaatat
      721 atatttggct aatacattat tttacacaaa cattacaagg gtctatttta ccttgtgact
      781 tagcttgttt taatgttact ttatttattg ttttacttct ttttagtgta gaacaatttt
      841 ttgttagatg atatgatttt ccattaggag ttacatatac tgtactttta tcagttaatc
      901 caggattatt agagctaggc tcattacttg gtttgttcgt attatttgaa ttagtatctt
      961 ttacaatgcc tgtatttgaa tccccaacat tattagttat atttaaacat tgttttataa
     1021 caacatcatc aatatttcca atagcagtta ttttacttgc attttttaat atactcttat
     1081 tacttccatt tccaactaac actataggtg ttttttgtgc aattgtagaa ccaactaaag
     1141 aataaactaa atcagtccca cttgctatgt aaaattcttt tgagccatta taaaatttat
     1201 ttattatttg tttatttgta tcgtatctat ctactccacc tattcttgtt gctttagttt
     1261 catttattaa cttatcacta atactgactt ttccaccaat tgcataagtt tctaatccat
     1321 ctgtagcaaa acttgtagtg tttccatcag ttaatactat tggagattta tctctaactg
     1381 ctatagaagc aacactcata gcatctggtt cacctttaaa agcattagtt aatattactt
     1441 ttttaacagc acttacactt cctatttctt ttgcaacttt atgacttgta tctattctat
     1501 cagttccact tattctattt atgcttattt ttttatcact taatattttc tgaactgatg
     1561 ctcctatcga attttttcct ccgattagat atacttcttt taccttttct aatcttttta
     1621 atgtttctga agggattgta tctttcttag ttaacaatat tggggcattt ttagctcctg
     1681 acaatccact tgctgacaat ccatcagata atccattttc agaattaata agtattgcaa
     1741 tatcataatt ttgtttatct gctattaaac ctgctgtttc atacttattt gtacctttta
     1801 ttgaattaat agaactaaga gcgtttgatg ttggacaact agcaatcaat aatgaaacag
     1861 acatccctat tgccaatagt gttttgttta atttcataat gaaatcctcc tataaatttt
     1921 ataatattac ttaaatatta taattctaca taaaagaata ttttccttta tgaaattagt
     1981 ttatatttca aaattttgtc actttttaaa tctatatact aaaaaataga ctatttgtaa
     2041 cagtctattt cttagtatat caaatattta tttaggttta cgtttctttg tactagtttt
     2101 tgtatatgat attccagttc caggtatact caatgtagct gattttcttc cttttgaatt
     2161 aactgacact ctagcacctt taacaccagc acttatacct acactcttct tacctaaatt
     2221 taatttgagt cctcctccta gatttatgct tttcctaaag ttaaatccca tagatataac
     2281 cttcccttct atattttaaa tatttatact taaaattata tttgttatac acttgccatc
     2341 attggtatat ctagcatcta tatcttttta cgttttttct tcttatatac tactccagca
     2401 actacagctg ctgttccagc tccaacccca taagtagcat ttctactttt ctcttcttct
     2461 cttttttcta aaccttcatc atatacacct tttaacttag tttcaataga cttcatttca
     2521 tctggtatac taaaatcttc ttcattgtaa ccttgattat atacactttc ttttgcttta
     2581 ggtaacttaa ccttaccatt atcatatcct tctttaaacc aattagcata tttaacatta
     2641 cctatagttg atgtgtcaaa tctttctcct ttgatagcac tctcaaatcc ttgagtagtg
     2701 taatcatttt ttaattgttc ttgtatttcg tcataagcat tattataagc atctataaat
     2761 ttagaatcta tgttttcttc aaatgtcatt ttttctttat ctttattgct atcctctatc
     2821 cctttagctt tatattcttc tatcttttta gtcttatatt cattgtatcc agttgaatat
     2881 ccggtatcat aagcattttt taaaacttct ttttcatatg tattattaga tttagcacct
     2941 gtaagcccta gattatatcc agtctcttta gcctcctttt cttcctcttc taatttagcc
     3001 ttaccttttt catatccttc tgagtacttt gattcatatg tatcactata atctccacta
     3061 taatttgatg aactataatt tcctttatac ccatcttcat acccttgatt atatcctttt
     3121 tctccaacag acctcttttg cttttcttca ttattaaccg aagttgctgt tccagaactg
     3181 cttcctcctc cagtataagg acaaccacca ttattatgta aatgagctgg ataaccacca
     3241 caatgatagt gataacttcc taatccagat ttatttttat tatcacgatg acctcctgat
     3301 gaatcagttc ttcctgaatg agcatacgaa aagctcccta cactaatcat agttatactc
     3361 attgcaacag ctattaactt tttcttaaac ataatctatt tccccctaaa atattctatg
     3421 attttattat atcagtcaat atattatgtt taaaccgtta aaattcgaca atgtaaatat
     3481 ttgatgaatt gtatttgtaa ataaatcttt tagcatatct tgaatatctg tagttgtttt
     3541 gacatcatat tcttcaataa gttttttaat atttcgtttt tgttaaacat aaaaagcgtg
     3601 cacttttctt tgtatagtga tatttgatat tttaattatc actactttag aagaatacac
     3661 actttatttt aaaaaccctg atactatgtt attagaaaat ggtactaata taaaagatat
     3721 ccagcatata ctcggacatg ctaaaacttc aacaactatg gatacatatt tacatgtaac
     3781 taacaacatg agaaaccaga cggtaaatat ttttgaaatc attgtagaat aaatttgcca
     3841 cccaaaaata attatggtgg caaataggtg gcaaatctac ttttaagaca cactataaaa
     3901 gtctgaaacc ctgttattct ctaataagtt taactacagt ctcacaatgt ggcgtatttg
     3961 ggaacatatc catacactta accatcttaa tctcataacc atacccctta aaatcaacca
     4021 aatcaacaac caaagactta ggattacaag aaatataaac aatctcctta gcaccaaatc
     4081 cacaaatatc cctaatagca tccttatgaa tgcctggtct aggagggtca acaataatca
     4141 aatcaggctt gtcctttaaa tccttaacaa ccttagccac atccccagca ataaactcac
     4201 aattagtaag tccattcaac ttagcattct cattagcagc aacaacagct tcctcaacta
     4261 tctcaatacc atacactttc ttagcagcac cagccataac ctgtccaata gacccagtac
     4321 cactatacaa gtcaaataca actttatcat tgtaatctcc aataaaatcc ctagcaatac
     4381 tataaagaac ctcagctccc ttagtattgg tttggaaaaa cgaaaatggt gaaatcttaa
     4441 acttaagacc taaaatttct tcttgtatat aatctcttcc atacaatact cttaactcat
     4501 cacattggac tgcatctgct aaaccatcat taatagtatg aagtacacct actaactcag
     4561 cttttaaatc aatccctaaa agcatatctt taaactcata catatcaaaa tcttcttgag
     4621 aagaagttac tatattaact ataatctcat tagtgtgaat cccttttcta actacaagat
     4681 gtctcaaata tcctttgtga ttcattgttc tataataagg aagctttttt tcattgaaaa
     4741 actctacact agaaactaat atctttgaga agtcttcatc aaccaacata cactcctcaa
     4801 cagtttgtat atctatatgc tttccttttt tatgaagacc taatgtcaaa ggtccatttt
     4861 ttacttcatc tccaaaagta tattccatct tatttctata atatttgttt tctggacttc
     4921 cttctatccc taaaaactga aatccaaata aatcttgctt taaaaataaa tccataactt
     4981 gtttttcttt tatttctaat tgtttttcat atggcacaga caatagtgta catcctccac
     5041 actctctaaa gtgcttgcaa gtttcttcag tttcaagtgg tgagttctct aataattcta
     5101 tcatcttaac ttcagctttc ttacttctaa cttttttaac tccagctctc accttttgac
     5161 cacttattcc acccttcata tggataactc tatctccaac ttggcttaaa gatgtaccac
     5221 caaattccat tttatctact tcaaattcta taacatcttt tttcttcaca gacattcctc
     5281 caatttacta tagtatcttt attatctttc ttcaatcaat tttacttctt catctgttaa
     5341 ctctctatac tcacctaact ctaaactttc atccaatttt aaattgccca tagacaatct
     5401 ttttaagtat actacttttt tgcctacgct ttcaaacatt ctttttactt ggtgaaactt
     5461 accttcatgt attgtaagct ctatttctga ttcatcatca ctttttaata tatttaactg
     5521 tgatggcata gttttatatc cgtcatcaag cactacacct tctaaaaaag cttctacatc
     5581 ttcttcagta actactccat caatttttgc ataataagtc ttaggcacat gcttcttagg
     5641 agataaaact ctatgagaaa gctttccatc attagttaaa actaataatc cctctgtgtc
     5701 tttatctaac cttccaacag gaaatggttc aaaagctaag tatgataaat caattaaatc
     5761 taatactgtt gggtcatatt tatctgtagt tgctgatata tatccatcag gtttattcat
     5821 catcaaatat atatattctc tatatataac ttcttctcca ttaaataata tctcatcatt
     5881 ttcagtgtct acttgagttc ctggatttga aacttcactt ccatttacta ctacagaccc
     5941 ttgtttacaa tacttcttta tttcacttct gcttccataa cctaaatttg aaagaatttt
     6001 atctatacgt tgctttttag ccattaaaaa tgctctccat tctcataata tttttctttt
     6061 tcaaatactg taaatgctaa atccatactt tctacatcta aattatttct tatactatca
     6121 gttattattc ttgctactat atcttgtact tcttgtcctc tatcaaacca agctacttca
     6181 acaaaaggat atacatctgc tattttacca tctcttattg caactgactt tatacattct
     6241 atttcaaagt agtctcttgg acattttaca gcttcaacta aatcatttat cattttttca
     6301 cttattttac atatatcatt ttcattaatt cctcttattt ttatctgtgg catagtttat
     6361 ctcctttatt ttaaattttt agtgaattat catccactta attcccttcg ataacgtttg
     6421 aagtggtaac ttcttggtca agacaactat tgttatcagt atctccaaac taataaggta
     6481 gttcctaccc ttatagttag cattatatag ctaattttcc taaattgttt atattcttta
     6541 ttattttatt taatcctatt gtcttctatt taacattata cttgtaattt atagttatta
     6601 caatttacta tatacttttt ttgatttaac gttataatat aagtgatggg taaattttaa
     6661 aagttaatag gaggagttta aaatggcatt aattactaca aaagaaatgt ttaaaaaagc
     6721 ttacgaaggt ggatttgcta taggtgcatt taacataagt gacttagaac aattacaagg
     6781 tgttttaaaa gctgctaaag ctaaaaattc ttatgttatg atacaagctt ctatgtcagc
     6841 tgttaaatat gctggacctc atacattagt tgaaatggtt aaggctgctt ctgatgaaat
     6901 aggtgtagat gtagctcttc acttagacca tggtccaaat atggatgcta ttaaaacttg
     6961 tattgatgct ggtttctctt cagttatgat agatggttct cattttgact ttgaagaaaa
     7021 tgttagaata actaaagaag ctgttgaata tgcacactct aaaggtgttg ttgttgaagc
     7081 agaacttggt gttctagctg gaacagaaga tgatgttact tctgatgttc acaagtatac
     7141 tcaaccagct gaggcagttg agttcgttga aagaacaggt gttgattcat tagcaatagc
     7201 tattggaact tctcatggtg ctttcaaatt caaaggagaa gctaaattaa gattcgatat
     7261 actagaagaa atccaaagca aattaccagg tttcccaata gttcttcatg gtgcatctgc
     7321 tgttgaccaa aacgctgttg ctacatgtaa tgaatttggt ggaaatatag ctggtgctaa
     7381 aggtgtacct gtagatatgt taagaaaagc atcttctatg gctgtttgta aaataaacat
     7441 ggatactgac ttaagactag ctatgactgc tgctatcaga aaattcttag ctgaaaatcc
     7501 aaaagaattt gacccaagaa aatacattgg tgctggtaga gatgctatac aagctgtagt
     7561 tgaaagcaag atagatgatg ttttaggttc tgctaactct ataaactaat ataactttta
     7621 aatatttata aaagaaaaga gatgacttaa agtaattaaa tttattttta agccatctct
     7681 tttaagttgt ataaattatg tatcttataa tattttaatt atattgtctt tttaaactga
     7741 cagctaaacg tgaatatgtc cactctttat ctttctatgg atggtagaag gatatatacc
     7801 tataacttca gcagcctttg ttattgaacc atacttattt atagccttac ttatcattat
     7861 ttggtccact attttatatg catcattaag attcataatt ccatttacca ctattggtga
     7921 taaatcatct gtttcattat caatcatatc taaatttatc agcatgttaa attcatcttc
     7981 tccaattaca tttttagctg ataatactac aaatctttca atgatgtttt ttaattctct
     8041 tatgtttcct ggccaagaat attcttctaa taactcaata actttaggcg aaacttctac
     8101 ttctctattg tacttttcat tgtaaagttt taagaaataa tttactaatg gtactatatc
     8161 ctcttttctt tctctaagag gaggtatttt tactggaata acacttaatc tatagtacaa
     8221 atcttgtcta aatttaaggt tatttctaag gtcttcatga gaaatattag tagcacttat
     8281 atatctaaca tctattttta taggcttact accacctatt ctagtaatag tattttcttg
     8341 tataacccta agtaattttt tttgcatctg cattggtaac tcacctatct catccaagaa
     8401 aatagttcca ccattcgcct cttcaaaaag tcccttttta ccttttttct tagctccagt
     8461 aaaagaacct tcttcatatc caaaaaactc tgactctaat aattcatttg gtatagctcc
     8521 acagtttata gctataaagg gtttgtctct ccttgaacta tacttatata ttgttcttgc
     8581 tattatttct tttcctacac ctgattctcc atttataaat atagaagaat ctgaggctgc
     8641 agctctctta acaacttttt ttatattgtc cataatctta ctttgactta tatactctgt
     8701 gtcttctgat atatcactat attttatctg agattcaagc ttaataaccc ttgaaatatc
     8761 tctccctgtt agtactcctc ctgtaagctt tcccttagaa tcccatcttg gaactgccgt
     8821 atatgcaata agcttcccat ctgggtaaac gatatttcta taaatctttt tcttcacttt
     8881 aagcatgttt aatattattg gttcttcaac taatccttgt ctcacaaggt ctgttatatt
     8941 tctaccaagt acctcagttc ttttaaaagg taatatctca tcactgacag tgttcatctt
     9001 ttcaattacc ccatctttgt taaacacaac aacaacttca tctatatgct ctattatatc
     9061 ttcaattact ttatcagata ttagagactt ctcaaataaa taaactatat tattttcatt
     9121 attattatct ttcatattgt atatatgtgc agtcatcctt aactctctga aagctatttt
     9181 ctttttacta tctgtcagta tttctgtttt gtcaaaattt gaatctaatt catttatatt
     9241 tctaggcttt tttatatcta gaaaactaaa aatactatct attagatgat tacagtatat
     9301 tatttcgcct gattctttac ataaaatggc tggattttct acatgttcta taagccctat
     9361 taaattatta tccattaata ttcgcacctt tcattaagta atttattgaa ctacatacaa
     9421 aatttattgt ttgcttacaa taaataccat cagcacatat aatcaactcc ttataatatt
     9481 cgtcttttca agtagtttat ttcattaaaa cgtaactaag atataatttt aatgattata
     9541 gtttgttaaa aatttcattt tgcttttaat tgtattttat cacatattta gtaattattt
     9601 gtctatttaa tacaatttaa ttaaatttaa gatttattta aaaaaacaaa gataatcctt
     9661 acagaatata actcacaatt tgtaagcaat atacatataa ggattatcca gattatcttg
     9721 tattataaaa ttttattcaa acagactttt taataactga caaatacaca ctagcaataa
     9781 cttatcaaag ggttaataat tatgttacta actaataaga cttattcaat cagtaatatt
     9841 tatatagttt gtatctatta agcttttata gcttctaata aatcatcaac gctatctaat
     9901 ttttctataa gcattggaac tatttcatgt aagtctccaa ctactccata gtcagcgatt
     9961 tctaaaattg gagctgctgg gtttttgttt atagcaatta tgaaatctga tgattgcata
    10021 cctgctaaat gttgtattgc tcctgatata ccacaagcta tatataggtt tggtttaaca
    10081 gtagttcctg tttgacctac ttggtgagaa tggtctatcc atccagcatc aacagccgca
    10141 cgagaagaac caactactcc acctaatttg tcagctaatt tcttaagcat ttcaaatcct
    10201 tctggtccac ctaatcctaa accacctgat actataacat ttgcatctgt aagagatact
    10261 aaatctttct tagttttaac tgtttctaaa acagtagttc ttatatcatc ttgagttatt
    10321 ttgtagtcta atgctataac ttcaccagtt cttgtttcgt ctttttcagc tttatccata
    10381 acaccaggtc taactgtaga catttgaggt ctatggtttg gacaaatgat tgtagccatt
    10441 atgtttccac caaatgctgg acgagtttgt tttattttct tatcttctgg gtctatttct
    10501 aacttagtac agtcagctgt taatccagtt ccaactcttg aagctattct aggtgctaag
    10561 tctctaccta tatgagttgc tccgaaaagc attatttctg gttttatttc atctattgca
    10621 tcttttatta cttttgtata tgcatcagtt gtatattttt ctaaaagagc atcatctgca
    10681 acataaactt tgtcagctcc aaaagtgatt aattctttag ctaatccatc aacatctttt
    10741 cctaataata ttgcacaaag ttctgcatct acttctttag ctaattttct tccttctcct
    10801 aataattcta taactactgg agctattttt ccttctcttt gttctgcaaa tatccatacg
    10861 tttttataag aacttaaatc ttttatatca ttcatagttt gtactcctcc aacttatata
    10921 atgtgctttt gttttagacc gattattatt ttactagcta tttcatcagc tttaccttct
    10981 aagatttctc cttttcctct tggttcagga gtaaatgatc taaatacttt agttggtgat
    11041 gcttttaaac caacttcttc tttatttaca tctaaatcat caattgtcca aacttttaca
    11101 tcatgtttat atgcttttac tattttatca acagacatgt atctaggtgt atttaactct
    11161 tttactgctg ttaaaagtac aggtgtactt acttttatta attcgtatcc atcttctaat
    11221 tgtctttgaa ctattatatc ttttccttct attttgaaat cttgtacata tgtaacttga
    11281 ggaatgtcta atttctctgc aatttgtggt ccaacttgtg cagtatctcc atctattgct
    11341 tgtcttcctg caaatattat gtcatagtca cctactttag atattcccgc tgcaatagta
    11401 tttgatgtag cccaagtatc agctcctcca aatgctctat cacttaataa tattgcatca
    11461 tcagcaccca tagctaaaca ctctcttagc ataaagtctg cttgaggagg tcccattgtt
    11521 ataactgtta tagttacatc atcatgctca tctttaattt ttaaagcttc ctctaatgca
    11581 tttgcatcat ctgggtttaa tatacttgga actccatctc ttataagagt acctgtttct
    11641 ttatttattc ttacttcgtt agtatctgga acttgtttta cgcaaactaa tattttcaaa
    11701 gtctatacct ccaatttcat tagattattt attattttaa tacgtttgat gaaattacca
    11761 ttttttgaac ttctgatgtt ccttcgtata ttgatacgat tctagcatct ctgtacattc
    11821 tttcgatttc ataatctttt ataaatccat atccaccgtg aagttgtaat gctttataag
    11881 caacttcatt tgcaatttct gatgcatagt atttagccat agcagattct tgagcaactc
    11941 tcattcctgc atctctcttt tgtgctgcat cataaactaa tcctctagct gcacaaactt
    12001 ttgtttccat gtcagctata gtaaattgag tattttggaa tttagctata ggcttaccaa
    12061 attgaactct ttgttttgta tatttaacag cttcatctaa agcaccttga gctattccta
    12121 gagctaaggc agcaacacct attctaccaa cttctagagt acccattgct atcttaaatc
    12181 cttgaccttc ttttccaagt aagttttctt ttggaacttt aacgttttca aatattaagt
    12241 cagaagtttc agttcctctt atacccatct tatcttcatg agctcctgtt gagaaaccat
    12301 cccatttact ttctactata aacgctgatg ttcctctaag tcctttactt ctatctgtaa
    12361 ctgctattac tatagctaca tcacagaatg gtccattagt tatgaaagtt tttctaccat
    12421 ttaatatata gtggtctcca actaattctg ctgttgtttg ttgtccacct gcatcagaac
    12481 cagctcctgg ctcagttaaa ccaaatgctc ctattaattc acctgttgct atacctttta
    12541 agtatttttg tttttgctct tcagtaccat tgtaaagtat tggtaatgaa gcaagagaag
    12601 aaccagctgt aacaaaagta gctgttgaag cacatcttct agctatttct tccattacta
    12661 tagcgtaaga aacatatcct gctcccccac caccatattc ttctgggata ttactgctta
    12721 taaattttgc atcagctaat tttttgatta attccttagg cattacacct gttttatcca
    12781 tttctgctgg taaagtatct aattctttac taacaaaatc tcttactgct tttcttaaaa
    12841 gttcttgttc tttgttatat aacatagctt cctccaattt tcatatttta tagtaaattt
    12901 attttaatga acttacgcta aactcatcat ctcagcaaaa gtttgaatac gagttctggc
    12961 ttgttcatta ttctgagttt gttggtcgat ttcaacatat aaagtaggta ttccactatc
    13021 ttctatatct tttctaacta aaggataatc gtattcttct gggtcacaga atttcatcat
    13081 acagaagata acaccatcta tatctttctt tttaacttca tctactataa gtgacccacg
    13141 ttttttctta gggtcataag ctaatgaaca tccttctatg tttgaccatt gtcttgctaa
    13201 tctctctaac gcatcatcac ctgctggtac atctgttctg aattgtcttg tttcttgtgc
    13261 taagtcgtca gctacaactg atatattgtt gtcttctaaa atgtctaata tatctttaga
    13321 atcagctaat atacctgtta ataaaacttt ctttccagaa cagacttctt ctggcatagc
    13381 atttaatttt gctattaaat ctttcactag ctcagtatgt tcttcttttc tcataaagaa
    13441 cccactctta attactaagc ttcttattga tggttttata gtattagaat gtttataagc
    13501 tacttcaaca aagtctctca tagtttttct atgttcattg taaacttcta tactttcatg
    13561 aatttttgct tcttctattt catatccaca aatttcttca agttctcttt ttacaccttt
    13621 gtactcactg attaagtatt ttacaccagc ttcaagtttt ctattttgtg ggtgtactaa
    13681 tgatatatat tttatatgag gtactgctga tttccagttt tgtcctaaac aaattagtgt
    13741 atcacacata cctggtataa taactccaga taattcatca taagcacctt ttaatccata
    13801 ttctaaacat gattgcatta ttgaacatgc aaatgcaggg aaatattgtt tagctaaatc
    13861 taattctgtt tgtcctcccc atataccaac tggaagcatt ccagctgcat gtataatttc
    13921 ttctgggcaa taaactggga aacaacctat agctttttta ccagtttcac ttttatattt
    13981 ttttacagcc gcatttggat tttcaactac ttctttcatt ttagataaaa tagcttccat
    14041 tatatctcac ctctattaag tttttttctt tcttccatta cttcaactaa accttgaatt
    14101 cttgtttcaa attgagcatt agtgaaagct ctagggtctg cttggtcacc atcaaatcca
    14161 gcatatggta atccagtttc ttcagctgct cttctttgca tttcatattg tattaaactc
    14221 ataagtttac agcttctgtt catatgatag aatgctccat cacatttacc ctctactaaa
    14281 gaatcaactc tatattttgt catacggtct aggtttacat tgttaaacat agtactatat
    14341 gctactgcca ttccatctaa atcattaact tcatattgta atgcccaagc atgtgggtaa
    14401 acactacctg tcatgttaac tccaaattta gctaatgttt tcatcttgta tcctatatat
    14461 ggccaacaag gtataccttc catcattatt ctgtattttt cttcccctct gaaagaagat
    14521 ttaccagttt tcatgttgtc ctctaattct tctataagta acttaaatgc ttctgtagtt
    14581 tcttttttac ctctagcaca aactattaca gccatgtaag taaataagtc aaatccattc
    14641 attggagaag gagaagaatc tgctggtaaa ctcatagaat acttccatag tcttccgttt
    14701 tcagctgata ttttcattac ttcttcaaac ttcttagggt caaatttctt tcctgatata
    14761 atttctagtt gttttatagc ttcttcaaat tgagctttaa tataatctat tcttgattga
    14821 gtaacttcgt cttcattatt gaaagttgta tcaatcatta ttaaaggtat atctaattct
    14881 cttgaaatat tttcatacca ttttataact tggttacata tattgttaca gcaaagtagg
    14941 aaatctggag ccggcatatc caaagcttca catccaccat tttctaaaag accaaaattt
    15001 gttcttgcat atgcacatag gtcaatagaa tatcctttag attcagctat ttcacataat
    15061 tctaaagaac cttttttagc tgctactcca gctgcttggt tttctggata taatacgttt
    15121 aagtcaaata cttctgctaa ctcttgagga aatactgatg ttgaccaacc tacaggtctt
    15181 ccttcttctt tagctttaaa tgcatttgca tattgttcag ctaataaatc attaattact
    15241 actctagctt cttttttttc agacattttc atccctcttt ttatatattt ttcacttctt
    15301 tttgtgattc ttttgcttca tcaaaagcat ataacgctgc tcctaaagca ccagttaatt
    15361 gaggtatatc aggtacaata atttctgtgt tgatttctct tgccatagct cttacaatac
    15421 cactatttct agcaactcca ccaaccataa ctacatttct ttgtactcct attcttttta
    15481 ctaggctaga aactctcttt gctactgaag tatgaatacc tgccactata tcttcaattt
    15541 ttgcattttc agataaatgt gatataacct cagactctgc aaatactgta catgtactgc
    15601 ttattgatac ttcattttga gaattcatag atatacttcc gagttcagat acatcaacct
    15661 ctattatttt tgccattaca tctaaaaatc ttcctgtacc tgcagcacat ttgtcattca
    15721 taagaaagtt taatagtctt ccattattat ctaattttaa tacctttgca tcttgaccac
    15781 ctatgtcaat aatggttctt gtctctggaa ttatgaaatt tacccctcta gcatgacagc
    15841 ttaattcact tatttgctta tcagcatctg aatagttcat tcttccatat cctgtaacta
    15901 caactttttt aatatcttct cttgcaagac ctgtcttgcc atataatttt tctaaaactc
    15961 ttgatggtcc agtagtccca gtaccagagg atattgtttc agaagctaca atatcttccc
    16021 cattctttaa gattactccc tttgatgcag ttgaacctat atctaatccc attgtgtaca
    16081 tctttagcat tctcctttta aaaaatctag aattactaat taatatctta caactttact
    16141 atctttaaag ttatttattt tctcttcatc gtagcctaaa gattttaata cttctacagt
    16201 atgttgacct acttttggtg ctggtgtata ttctttaatt ccttcatttc taaacataac
    16261 tggagtatta actaagacac ctgtatttcc gctatcgtat gttttcttaa ataagaagtc
    16321 atttgcccaa gcttgttcgt catctaataa atcttcacag ctttgaattt tttcaaatgg
    16381 taagtctgct tcttctaata aagctgacca ctcgtctaat gttttttcta acatagcttc
    16441 tccaactatc ttaactaaat cttcaacatg attaaccatt gaatctatgt tattatatct
    16501 atcgtcttct aatatatatt ctctatttat aaccttacag aatttgccta accacttgtt
    16561 gtattgtatt aaagctaatt gaatccatct tccatcttta catttatatg tagtcattaa
    16621 tgggctgttt ggattttctc ttgataaagg catttcattt ccgtattgtg ctgttgttat
    16681 cattgttccc attccatata tagctgtatg gaaaagactt actgttactc tctcaccttt
    16741 accagtttga gcttttttat gtaatgctgc taaacttcct gctgctagtg ctagacctgc
    16801 atagtggtca ccaaatcctg ctgctgtatt tgctggagat gttccttttt ccataacaga
    16861 ttggctaact cctcctcttg cgaagtatgc agtatagtca aatcctggtt tatcttttaa
    16921 aggtcctttt tcaccatatc ctaatatttg agagaatatt aatcctggat acttatcttt
    16981 tatttggtca taagctatac ccattttttc taatgcttga actctaacat tagttacaaa
    17041 tatgtctgct tctgataata atttatgtaa tatttctact ccttcttttg attttacatt
    17101 aatacttaca ccctttttat ttccattttc taattcaaac atagggtttt catcatctga
    17161 tgctggagat ttaaatgttc cacccataac tcttattcca tcaccttcta taggttcaat
    17221 cttaataacc tctgcacccc agtcacctaa catttttgca caacatggtg ctgcgatgaa
    17281 acttgaaagt tctactactt taactccttc taaaagcata acgttttcct ccttaatagt
    17341 atcaattata aaatttcgat taaatcactc ataaaatact tttttctgat attaactgtc
    17401 tgatgtcaaa gttcctaatc ttatctaaaa taacttaaaa attattaaaa ttatttttta
    17461 ttgttttatt gtcttacacc tatattgtta agcatttatc gtgccaactt tatatttaat
    17521 caaaatatcg cttgatttga atgtttttta acaatatgca attgaataat ctttttcata
    17581 tcgtggcatc ttgccactat ccattgcatt ttgctattct ttctatgctt ataaaagttt
    17641 tttttatata tttttttatg aaaaagcttg acatttcaaa aaaagttttc attgctaaac
    17701 tcaaaaacac atgttatcat tgtaattaat cagcaagtta gttaactaat ttcaaactta
    17761 gataattttt taataatatt taatctaaaa aataacaatt tctttgataa attttagagt
    17821 aattattaca ttaaataaaa aattactaaa tatcaaaata acacagggaa aacaatttca
    17881 aaactaaatt tttaacctta aaaattttgt ataaaaaata taaccttata tgctacatat
    17941 tatttctaaa tgaaaaatta ccataataat ttaataatta caggagggta ttgatatgaa
    18001 aatactagta tttggagcac gcgattatga agaaccagta ataaaaaaat ggtctgaaga
    18061 acataaggat gttcaagtgg atatttatcc tgaaaacatg actgaagaaa atgtagttaa
    18121 agctaaaggg tatgatggta tatctataca acaaactaac tatatagata atccttatat
    18181 ttatgaaact ttaaaagatg ctggggttaa agttatagct tcaagaactg caggggttga
    18241 catgatacat tttgatttag ttaatgaaaa tggacttatc gttacaaacg ttccttctta
    18301 ttcacctaat gcaatagctg aattagctgt tactcaagct atgaaccttt taagaaagac
    18361 tcctctagta aagaaaaaag tctgtgaagg tgattaccgt tggatagctg aacttcttgg
    18421 aacagaagtt agatctatta cagttggtgt tataggtaca ggaaaaatag gtgctacttc
    18481 tgcaaaatta ttcaaaggcc taggagctaa tgtaattgca tttgaccaat atccaaatag
    18541 tgatttaaat gatatattaa cttacaaaga ttctttagaa gaccttctaa aagaagctga
    18601 ccttataaca ttacatactc ctttacttga aggaacaaaa catatgataa ataaagatac
    18661 tctagctata atgaaggatg gagcttacat agtaaatact ggccgtggtg gtttaattaa
    18721 tacaggggat ttaatagaag cactagagtc aggaaaaatt agagctgctg cccttgatac
    18781 atttgaaact gaaggattgt tcttaaacaa aaaaatgaat cctggagaat taactgaccc
    18841 agaaataaat aaacttcttt ctatggaaca agttatattc actcatcacc ttggtttctt
    18901 cactagtaca gcgattgaaa atatagttta ttctagttta agtagtgctg tagaagttat
    18961 aaaaacagga actgctacta atagagtaaa ttagtatttt ataaatatat tttttcatta
    19021 attagctatt atctaacaaa atagccttta atttcccaaa tataagagag tcagctcagt
    19081 atatattgag tagactctct tatattattt tttatattaa acttgtactc ttcttattca
    19141 taccaaatta aatttatatt aacttactct aactactcct actctataca ttttacctat
    19201 ttttactttt ctaattatat acatttgaat gggtacaatc tgtattttac aaaaaaaaca
    19261 cctaacaaac tatgaaaatt gtatgattaa tattaatata tttataagaa aacataacaa
    19321 ttatgttagc tctggatttt tagggaggga gtatattgga aaaaatgaat aaagttactt
    19381 ctaaaaaaac tacctatatt gttacttcag cattatttgc atccataata tgcctgacaa
    19441 tagcatatat attacatatt ccagttggtg gaaacaatgg atatgttcat ataggagatg
    19501 cttttattta tctagctgca actattttgc caacaaacta tgctatagct gcttctgcaa
    19561 ttggtgctgg tctagctgat ttatctacag gtgctgctat ctgggtaata ccaactataa
    19621 tcataaaacc aatacttgta ttatttttca cttctaaaag tgacaagata ataaataaga
    19681 gaaatatagt tgcttcggtt gtagcaggta tagtaggatt agttttatac atgtttgctg
    19741 aaggtataat tattggaagt tttacaagtg catttgtaat gagcttactt ggcttattac
    19801 agccaatagg aagttttatt gtttttataa tcttaggtat ggcacttgat aaacttgatt
    19861 ttaaaaaacg ttattttaat taagaattta aatttatgga gggaaaatta tgaatatctt
    19921 atatacaatt gaaaatagta tctatgtaaa tataactaat acatgtccat gtagttgtgt
    19981 tttttgtata agaaacgaaa aagatgaagt tgcaaatagt ggtagtttat ggttggagca
    20041 tgagccaagt gtagatgaag taaaagaagc cttcaataaa tacaatttag acgactatga
    20101 tgaaatcgta ttttgtggat atggcgaacc attaatgaga ataaatgaat tgatagaggt
    20161 agcaaagttt ataaaagaaa aaagtagcat aaagataaga ataaatacaa atggtctaag
    20221 tgatttaata cataacaaaa aaacagctat tctgttaaaa aatgttatag atgcagtatc
    20281 aataagtctt aatgccccaa ataaagaagc ttataataga gttactcaac caaagtttgg
    20341 agaaaaatca tttgattata tgttagattt tgcaagagat tgcaaaaaat atataaaaga
    20401 agtagctttt tcagtagtag atgaaatatc tccagaagaa atagaagaat ctaaacaact
    20461 ggcaaaaaaa cttgatatac cattaagggt tagacataag aattagcaag taaaattata
    20521 aaacattaag aatcacctga atggtctttc aggtgattct tcctcttgta ttaacatttt
    20581 acaaaataga tttcatacca cactaggaat gtgtaaatca tccaaatctt tctccaatta
    20641 tcagagtttc cactaatgta gtcattaaaa atctcattaa tctcatctat gttaaagaat
    20701 ttatctgcta tctcactatt gaatttatct cggatatcct tattatattg gtcatcagcc
    20761 atccatatac gaattggcac aataaatcct aatttatttc taaaagcaat ctcttctggt
    20821 aatgtttttg atgcagctgt acgaaaggca attttattct cttttccttt cactttatat
    20881 tctgatggta ttctggatgc aatatcaaat attcttgtat ctgtaagagg cattctgact
    20941 tccaatccta ctgcagtact cattttatct atattaaaat aaatatctcc ttccaaccat
    21001 atttgaatat ctacatttga catgttagta agtgtatcta gttcttctgt ttcttcataa
    21061 attcctttta ccacttcaat aggaagcaca tcaggattgt atttcttaag aatttttctt
    21121 ttctcaccct cattcataat gtttgtattt ccaatataaa atgtcttcaa attctctcca
    21181 taacactctg ccttatggta tatattatat ccaccaaaaa actcatctgc tccttctcca
    21241 gagtaacaga tatttgtgtt ttcagctgct gccttgcatc caatagcaaa aacgatagca
    21301 gatgcatctc cagttggttg ctccatatgg tacattacat aaggtactga cgcaaaatac
    21361 tcttcaggtg taattatata tctcgaattt ttacacccaa gaatattagc tgtctgttgt
    21421 gctaattttg attcatcaaa acgctcttcc tcataaccac atgaacctgt tttttctata
    21481 tctgacattg ccaatatata agatgaatca acacctcctg ataggaataa ctctgcagtt
    21541 tcattctctg attttacctc tggcataatt ttctgaagtg ttgtatgaat ttcatccgtc
    21601 cattcctcaa tagacttgct gtggtcagga tgaaattcag gtttccaata acgaccaata
    21661 catactgttt tattctgata gacaaggtaa tgtcctggca taagcttctt tactccacgg
    21721 aagaatgtat tttcacctgc tacatatgtg aaagacatat aaatctgtaa catgtcttca
    21781 tttaactctt tcacaaatcc tggttgctcc ataatcttac gaatagatga accatagaga
    21841 agcttcccat tttcagtctc ataataatag aaaggtttta ccccaaactg gtctcttagg
    21901 cagaagagtt tcttttccac agtatcccat aatgcaaaag caaacattcc atgcatgtga
    21961 tttgccatat catatcccca tgtcttatat gcttccacta aaattgctcg ttcacgctca
    22021 tctctacata atgaagaatc gattccaagt tcttcacaaa gaactttcca gtttcgaata
    22081 tgcccattgt attctagaat ttttatcata tatgtgtctt ttcgtgttaa atacttttct
    22141 tctaaattta tcatatgtgt atcctttcgt attaaaacat ttaacttcta aatttattaa
    22201 atgtttatat atatttattc acttataatc actgaaaaat cgactttttt caaagtaaat
    22261 tctttttgaa ttagtactaa tctgctcttt attaatggca taaatatgat tatcaagtat
    22321 tatcagtgtt ataacattga attttttatt cttcataaat attgccccct ttatattacc
    22381 aactaaatat aatatatctt atgttactta catattcttt aagaaattct gaagatttta
    22441 taaagttttt tgtattataa ttaattaaaa ataaaattct agttataaaa catattttcc
    22501 attaaacaaa aaaatagtta aaataaattc ataaccacat aaacttattt taactatttg
    22561 tatattttaa ttataaatat taacttaaat ttttaacagg atacactcat aaaataaaca
    22621 taatgaacaa caaaataata tgtctcagtt tctttatata ctttaccttc tttcaatttt
    22681 ctaccatgta gacgtataag ataatattag taattcactc tattgcttaa ctcgtgcgat
    22741 atggacaacc aagaaagcta tttcctcatt tgttaacttt tttccatatt tcttttctaa
    22801 aaaatctcta acttttaatg caattaacat ttcttttgga tttgaccttt tcatttgatt
    22861 aaataataaa tcatcaccac tgcttaacat actatctgaa aaaaatcttt ccacaaaaaa
    22921 ttttatatgt gttataaatc tcatataatg catactcttt ttatctaagg ttctattcaa
    22981 agaaaaaaca aaaatattaa ttatttctcc aattactttg gcatacttaa tcgtatcata
    23041 tgaatttcca tctgaagcca tagcatttgc aaaatggaaa gcaatgttag ctgcttcttc
    23101 ctctggtaat tgaatgccca atctctcctc taccatataa attgcaacca ttccaacctt
    23161 aaactcattt ggataataat tttttatttc ccaaaatact cgatttgtaa tttttattcc
    23221 tttacgcatc ctttcaattg caaagttaaa atggtctgct aatattaagt ataagttttt
    23281 attaaaagat gagttcaata acttttctgc ctctactatt atttcctgtg ttatctttaa
    23341 aatgtcgaca ggaatatcat ccattaattc taaaaattgt tttgattttg tattttcaac
    23401 agggacaaac atttgattat cattggaacc acaaatatat tctcctgttt ttttaccata
    23461 tccaattcct ttccctagca aaataaattc attatccttt gtgtcatgaa ctaaaacaac
    23521 gctcgagttc aaaactttct ttattatgta gttcatttta tttgctcacc ttctattggt
    23581 catttaaaat ctatactatt actttcaatt acctttttat accaataaaa actatctttc
    23641 ttatatcgat tatatgtccc ctttccataa tcatcagcat ccacataaat atatccataa
    23701 cgttttgaca tttgtttcgt tgattcactg accaaatcaa tacaacccca tgaagtatat
    23761 ccccaaagtt caacaccatc ttcaataatc gcatctaaca tacatttaaa gtgttctttt
    23821 aaataattaa ttctatattg gtcatgaact tttttatctt cagttaaaat atctttggct
    23881 cccaatccat tttcaactat aaataaaggc tttctgtatc tatcatataa ttcaatcaaa
    23941 gatatacgta gacctattga atcaatttgc caaccccatt cactcatttc taaataagga
    24001 ttttttacag ctaataacgt attcccaggt gtaatatcta atccagttgt atcagctgcc
    24061 tcacaagaag acatatagta agagaatgaa ataaaatcta ctggatactt tttcataatt
    24121 tcatcatcat gttcttcttt tactatttga atgttattat ttttaaaata cgacagtaaa
    24181 tatactggat actcaccaaa aacctgcgta tcactatatg cataaatact tctcattttt
    24241 cgttgagttg ccaaaacatc ttctggtcta catgtgtatg gataatacgt taattttgtt
    24301 aacatacacc ctacttttga atttggaata atttcatgac aaatttttgt tgcaagggca
    24361 ctagctacaa attgatgatg catagcttga aaaataactt cctcaaagtt tttatcctta
    24421 aaacggtctc gaactaaacc accagtagtg tacggatgac gaatcataga atcaacttca
    24481 ttaaatgtaa gccaatattt cactttgttt ttatatcttt cacagatagt ttctacatac
    24541 ctaacaaaca tattgataac ttgtcgtgaa taccatccat catagtttaa aacgatattt
    24601 aatggtggtt cataatgtga catagtaaca agtggttcaa ttccataact tatcaactca
    24661 tcaaatacat catcataaaa ctgtaaacct tcttcatttg gctctttatc atctccattt
    24721 ggaaaaatac gagaccaagc aatactcatt cgatatgtct taaatcccat ttctgccatt
    24781 agagcaatat cttctttata gtgatgataa aaatcactac catgacgttt tggataattt
    24841 acttcatctt caggatgtgc taatccttct tctatatctt ttgttgtgat ttcattatta
    24901 gatttataat ctttcacatc tgcatcaaag tgtgcctttg ctacatctga tacagaccac
    24961 cctttaccac ctaaattcca accaccttca aattgattag cagctgtagc tcctccccaa
    25021 agaaatcctt ctggaaactt tctcatattt atattcctcc ctttacatca aacaagatac
    25081 ttcctttttt tacattgcca taagactggt ttaacacttt ataagcataa tctgctccat
    25141 tattgtttac aatcataaca gttgaatcta aattagcatg tgagattttg tctaaatcaa
    25201 actgaattaa taaatctcct tcttttacat tatcgcctgt cttaacaaat gttttaaatc
    25261 catctccatt catacttaca gtatttattc caatatgaat caaaatctca gccccatttt
    25321 ttgttcttaa accaattgca tgttttgttt caaataacat cacaacttct gaatcacaag
    25381 gtgcgtataa atttccattg gtcggtataa ttgcaactcc atctcccaaa gtcttacttg
    25441 caaatagttc atcattaacc ttacttaaat ctattacttt tccttctact ggagttacta
    25501 agatatttac ttctttttct tcttctagct cttcttcaac aacatctcca attgatgact
    25561 ctactgtatt tgtatcttcc ttccaaataa tcagtgtaat aataaacgag cctaatattg
    25621 caataacaaa accaatactt gcaaaaatca aattgtttcc attgtttggg tcaataaaca
    25681 tactcatact ggcaagccct ggtccaacaa ttacaaatcc ttttactgca aataatccta
    25741 aaaatgtacc agaaattgca cttgagaata caacacctaa cattgctctt ttatgttgta
    25801 aagtaatacc atataaagct ggctctgtaa ttcccatcaa ggcagaaatt cctgcagata
    25861 atgctgtttg ttttaatgtt tcatcttttg ttcgcaaggc tactgcaaaa caagcaccac
    25921 tttcagaaat attgtgggct aatgaagatg tcatatataa agcttcataa cccaactttc
    25981 caattgtatt aattgaataa ggtattagtg ctttgtgcat tcctgttgca accataaatg
    26041 gaagaaaagc agcaagtaat cctacaacta agaatcccat tttgttatat aagaataaaa
    26101 taatggttgt aaaaattgta ccaacgttat atcctaaagg acctaaaata gttagagtaa
    26161 ttggaacagt aattgccaaa gacatcatag gaacaaagaa agttcgaatt ggttttggtg
    26221 aatacttgtt aaaaattttc tccattgttg ccaagaaaga cacacataag atagccggga
    26281 aaacctgtgc attataggca atgtttggaa ttgtaaatcc aaatagttcg acaccttcac
    26341 ttaaagcagt tgttgttgct ggaagcaata agtatcctac agcggcaata gctactaaac
    26401 gattacattt caatacattg gcagtagtta cagctaccat aagaggtagg aaatagaatg
    26461 ttgcatctga aatagcaact aataatgtat atatagtaga atctgatttt aaaatattaa
    26521 acattgctaa taacatcaac agtgatttta aaataccagc tcctgcaata gcaaaaatca
    26581 gtggttgaaa aatattaata ataaattcta taaatcttgt tcctaagttt attttttctt
    26641 cagtttttac agtactatca tttgtatcta aagggcaaac ttttaaaatt tcatcataca
    26701 catcaacaac actatttcca atgacaactt gaaattgtgc cccattaact atactcataa
    26761 caccttgtac tttttttaaa gcatcctgat tgactttact tctatcaatc aacttaaagc
    26821 gtagtctagt tgaacagtgt tctaaagcta aaatattttt tgaaccacca acttgttcaa
    26881 taatgtcaat ggcagttttt ttataattca tcttgtaatc tccttctcca taatttttta
    26941 tgaatggcca ttcaagatgc aaaaaaggca gaacctatat aaacaccttg aaaaatcaaa
    27001 gcaatatatt cgatcctgcc tgcattacca gtaacatgtc ttctatttat actattttgt
    27061 attattatat taacatttgc ctaaaagaat tgtcaatact tttttaaatt ttctgatact
    27121 aactaatagc acctttataa ttcatttttt atatcaatta aagtaacagt agccacccac
    27181 caattagtat caaaattgaa cctggtattt tttcttttat attttctttg aatataaaat
    27241 gagcaagtat taaagttatt atcatagata cttgagaaaa tggctctgct atactaagtt
    27301 ctagattatt taaagcaatt aataatgcta aataagaata tccattaata gcaccactta
    27361 aaattgaaag ccccttttta ttactaaaaa tctcacaaat tattttttgt ttctttttaa
    27421 atgctaaaaa gataaataaa tttaaaccta cgaaaaaata cagtatagtt gaatataata
    27481 taggagatac ttgtacaaaa aaagccttat ccaatactct tcctactgac tgcaaaaata
    27541 tgtataaaaa cattaatcta catggtaaat tgttaaaaat tacagagaca ttctttaaaa
    27601 aagagcttac tttttttaat ataaacactc caccaatcat aattatgatt cctgcaactt
    27661 ttgctaaact taaaccttca cctaaaaata taactgataa aagcagtaaa aacaatgaat
    27721 ttaaactatt tattggagta acaagtgaaa cttccccagt tgctaaagac gttacatacg
    27781 ctactgaacc aattgaatag actaaactac ttatataaca tggtattaaa aacgaccaat
    27841 cactaactct atccattatg ctaaatggaa gtaaacatac tccccctata aagaaaaata
    27901 gaaatgatga agctatattt ttataaatat ctccttcttc atcacctaat aatcttacaa
    27961 ctactctttc aaaagctaat agcactactc taattaataa tgcaaaataa gataatatca
    28021 tttttgacct cgcttaaaaa ttaatccgac ttattgttat attaactgta taaaactacc
    28081 atataggtaa gtcttttgga ttttttaata ttttatgttt aaatacaggt acattaagtt
    28141 tttcacctag tttacgacat tgctctttat aggtaccttt taatttatca tgaaaaacta
    28201 tacaatcaat tcctccttca atactattta tacacttttc tagtttctca aatccagatt
    28261 catcatcata cattccactt acaatccatt gatttggcaa tacatgtcca attgatatgt
    28321 tatattcttt attttttata atatctgaga aagatttctc aaaatgtacc cctccaacac
    28381 ataacaaagt cttcaaaggt tcatcacaat caaatactct aattaatgat tttgccaata
    28441 cctgtattgc tatactatta ttaaaactat cactactact tcctatctca atatccaaca
    28501 taggtacaga atattctgta attaatttag attcttcacc atatgttgtt ccagaccagt
    28561 gagttgcttc tgttaatgta gtaaattcat caagtagatt ttcatttttt atatcctcaa
    28621 tagcattgat tagattttta aagtatcttg gatttgaatt tccaaattct cctgttggaa
    28681 catctccaat tgtatgagct gttaggatat gttctggagc attttctccc tcatgccaat
    28741 ttacaactcc tgcaaaatca taatctctaa aatgtctatt taaaattgga agataatatt
    28801 tataattatg acttattaca tcttttgttt ttacaaaatg aaataagtta ttgtttttat
    28861 ccttaaactc taatacaaaa ttatcatcaa taacaatatc agtttgattt aaatccatta
    28921 tttcttcaca acattttatc acattactgg ctactgggtc tttctttaaa tcactgcaaa
    28981 agaaaaaaac tgctttttta ttattcatcc ataaatcaca ctcctataac ttaaatataa
    29041 tatatcttca tacctaaaat catctaaata tcactctaat tccattaaat tatttatata
    29101 taatatacta ccatactcat tttagctata cctttgcctg agtttctata tatatgtgat
    29161 acatcagctt taaatcttat agaatttcca ctagatacaa tgtaatcttc tccatttatt
    29221 ttaatggtta cttcgccact aaaaacagtt ataaactctt gtgttcctgg aagttcagca
    29281 tttgaatcta aatttccacc ttcttctatt tcaatcataa atatctcaaa tcttcttttg
    29341 gagtcaaatg gaaatattgg ataacttata tactttccat tatcttcaat aaaatggtct
    29401 atatcacttt tttgaatcaa ttctatgtca ctttcctgcc tctccatcaa tgatgtaaat
    29461 gagattttta gcccattagt tattttcttc aaagtagata tagtaggatt tacctcacac
    29521 ttttcaattt gagatagcat actcttactt acaccactaa gttgtgcaat cttgtctaaa
    29581 ctaagatgtt tttctttcct tatctttttt aaattttcag caattatttc atttaaactt
    29641 tgcataaata ccccctaata catactaata taagataaat tattttgatt attaaataaa
    29701 cttagtaatt taatagaaac tttttatcca ttataatgta cattatgttt aatatacatt
    29761 acttttttta gaatgtaaat agttttctga aattttgtga aaatgaataa ataaaaaact
    29821 agtaacctat atttttacaa ggttactagc ttttattata ataatctttc attttaacta
    29881 taaaacttag atgcacctat aagctgtctc ttagaaacaa tcttagctag gtttgctaat
    29941 gaagaaattt ttatatcttt aaaagaaact aaaaatacaa acttaaaatc tgtaaattct
    30001 tgatttatat tgtatatatc aaaataacat ctcaaattat caaataagta attatcctgt
    30061 aagtctgctt ctatctcatc agtagcatct tttaaatacg ctcttacatc ttcaaataaa
    30121 acactgaaat aagactcatc tatttcttca cctaactctt ccaatatttc ttctatatct
    30181 aaatcatcca tatcaaaaga atttcctgtc aactggcaat caaataccaa tatattttct
    30241 tgatttatag tatttgatat atcttgtaca tattcgaagt ctggacgtaa ttctaaaatg
    30301 tcttttattt cactgctctt tacatggatt tttccttttc tattttcaat ttttaaatct
    30361 atcatatgct ccccctttca atctacaaat ctttaaatac cttgttttat aatcttttca
    30421 atatctatcc aattactaac tctaactata ttttgatgtt taacatcttt attatagtta
    30481 gtatccagaa gtattacttt aacaccatca tcagctagtt gcactgagtt taaaggatta
    30541 tcttctataa atatgtcaca actcagttct cttgcctttt caactttata atcacttcct
    30601 aataagtaaa catctatatc tgaaaatcct tgtctcgata gccaattttt agttacatca
    30661 gttaaacact catgtctagc cgttacaaaa gataaattat gtcctttaga taatgtgcta
    30721 attacctctg tagcaccctc tacaatcttt gcttcatcat atgagtgtat atacttatta
    30781 ttaaactccg catacacatc tcttattccc gaaccataca attcttccca attatgtgtt
    30841 atacactctg cttcagttat atttttatta aagatatcat ttaggtatgg aagaaaatga
    30901 taagggcttg ttattgttcc atctatatca atacatatat tcaatttgtt catttttacc
    30961 tccatgtaac atttattgat ttgattaatc aaatattata gcacagcttt aattataaat
    31021 caaaactctg gatatgacta tacctatata ataccaaaaa gcttgcatat ttaagcaagc
    31081 ttttcgtaaa ttttacattt ttaactaata tataagtttt tctaaggttg gttccactcc
    31141 aaattgtgat ttcagttctt tatattcttt taatgctttg tcattattcg ttttagtttt
    31201 tatcgctctt atcattaaat tttttggtgt atcaagtgga gatatgtatt ctactacaga
    31261 agtatcatat ccattgccct ccaataacaa tgttcttaaa ccatcagtta ttaaatctgc
    31321 aaatctagct ttaaatacac catgttttaa tattggttcc atagcttcat atctatattg
    31381 ccctaatagc tccttatgac aacatggtac tactactata gcttcagatt ttgctctaat
    31441 tcctagacct attgccatat ctgtagccgt atcacaagca tgtagactta ttacaaggtc
    31501 aacatcccta ttaggtgtat aattagtcaa atcctctttt ataaatgaca tatttttata
    31561 acccaagttt ttagccatat tttttgatgc ttctataact acatctgaat aatctattcc
    31621 tataaaataa cagtttttct tcaatacttc ttttatataa aaatttaaga caaagcttaa
    31681 gtaggatttt ccacaagcac aatccaagat agttatacag tctttatcct ttatttcttt
    31741 taaaatacta tctatcaatt caacaaaatg gtctatctga ttgtattttc ttattttatc
    31801 attttttatc ttaccatctt ttgtaagtac tccaatttct tttaaaagtg catttgcttg
    31861 tcctactttt acataataat ctctgttttt tatttgagat gccgtaaatt catctatttt
    31921 aggtacttct tccttattat ctaaatattt tacatttacc ttcttattgt ctccttcaat
    31981 tacaacaata gttcctcgct caacatattt aaatactaat ccatcataat tttctgcctc
    32041 tttagaaata ttcttaagca actcattaaa cgtatataaa tctgattttc ctttaaaatt
    32101 aaatttatat ttattatctt cctctattgc aattccttta aactcttttc ttccagattt
    32161 aaaaatcacc tctaactcaa taaaaaaatc cctattatca aggtttcttt gagtaatccc
    32221 cataaaaaac atatttagtt ttcctatact ctgtttattc atcataatct cccttttaac
    32281 ttatatcctt aaatcttatt aattaatatt atttgtttct gaattattta tttcttcttt
    32341 taaatcgttc aatctatttt taaaactttc tatctgctta tctgataaat caagatattc
    32401 tgttatcttc cctatatatt tagggctttt agtatttatt aatttcaaag cactttccat
    32461 agatttttct ctaagctcat atgctttctt tacgtcatct ctagcattac tcaatgtttc
    32521 tgtatacttc tccttagaaa gttctggaat ctgcatattt tcatattctt ttacaacttc
    32581 tttacacttg tttctggcat ttgtaacatc tttttttata ctagataatt tagttatatt
    32641 ttttgctata tccttagtgt aaggtatgca ttctctcatt ggaactaaag ctgctctttc
    32701 tatattataa atttctttct taaaaattcc tatactttcc atatctattt tttttatatc
    32761 ttcactattt ttttctttac ttgtatattt attattttct tttgtattat cttcttgttt
    32821 ttctgattta ttattcactg aaacattact atcagaatta ttcttttctt ttatatcatt
    32881 acttccttct tcattacttt ctttattttg tatatttcta tcttgtttgt tgtttaaatt
    32941 tttattattt gatatttctt cattcttttt attatcctgg tttaaatcag tactttcttt
    33001 ttccttaaaa tttgatacat acttttcatc atatgtctca tcagaaatat aattgtgata
    33061 atacatagac tcttttattt tattaagtcc actcatataa atattactta tcattattgt
    33121 tgtagctaat accacataaa tactactgta gatacaagac ctcttaaaat tcttgtaatt
    33181 tctgaatatc actactaaag gaataagata taaaaatata aaaactaata tccacctcat
    33241 aagtcgtgtc tcctttctca aaaccgaaat ccctcaaata tttattttta atcatgtatc
    33301 ttatagtatt taccaattta tgttttttaa tcgtgaactt ttattaaatt aaattctgta
    33361 tagtcacaag atgctaatgt atattctact ccatttcgaa tccccttcaa tcccatttta
    33421 aaagattctt taccatgcaa gtgaccataa atcacctttt caacattata ttcttcaaat
    33481 aactttgtaa ataaagattc ttccaattta tcattcgtag gaggataatg agtaatcaca
    33541 attatttttg agtgaccact tttacgagca gattctaatg atagtctaag tctatgttct
    33601 tctcttttat aaactttttc atcagtctca tcaaatttaa catcattagg acatatccag
    33661 cccctacctc cacaaattgc ataatcttta tattcataaa aatttgtctg aataaaacgc
    33721 atgtcttcat atagcttatt taaacttgta acggttgtcc accagtaatc atgatttccc
    33781 tttataagta ttttctgacc tggaagtttg cttattatat ctaaatcttt tttagcttcg
    33841 gataaattaa ttccccaaga tgtatctcct agtactaaga ccatatcttc ttccttaaca
    33901 acttctttcc aattatctat aattttcttt tcatgaccat cccaattact tccaaagata
    33961 ttcattggct tattgactga tgttgaaaaa tgtaaatcac ctatagcata caaactcata
    34021 atatcattcc tttcttaatt acactaaata ggctgtctct ttttagaaat tattttccat
    34081 taagaggcag ccccattaat atttagcaaa ttttctacaa gtagttttta ctgaactact
    34141 ttatcatcta ccttagtatc cttatattgc tctaataata tatctatttc ttgttttaat
    34201 tccaaaattt cagttatatt tttatctgtt tcagttctat caagttttct ttggtactgc
    34261 atagctttat gtgtatcacc caagtcatat aactcttgta ttctatttag agtatctcta
    34321 atagctatag acttcatttg gtacatagcc tgagctttca ttatgtcctc tcttatttca
    34381 ctcatttctt ggtctaaaag aaaggcagca tcagatgctc ttctaagcct ttcagcaaga
    34441 gtctcaggta tgtaatggtc atatttatat tttaatgaat gttctattgt agcccagaaa
    34501 ttcattgcaa gagttcttat ttgtatttca catataattt cctttgaacc cgcaatggag
    34561 tttatagggt attttattat aacatgatag cttctataac cactatcttt gtaatttgta
    34621 atataatctt tttctcctat tatagtcata tcatttctta cttttatcaa atcaactata
    34681 gcatatatat cctcaacaaa ctggcacatt attcttatac cagcaatatc atcaatttca
    34741 gtttctatat cttttgcatt tatccttttt aacttagata ttatggaaga tatttttttt
    34801 gttctacctg tgacaaactc tatgggagaa tattcacctt ttgctaaata ttcttttctt
    34861 atatttttaa attttatttt taattcctct actgcatgtt cataaggtgc tagtatctca
    34921 ttccattttt cgtattccat attgctcacc ctttatttgt tttttatgac cttctttatt
    34981 ttatcataat ttattttgtt tttgtatagt aaagcaattc tccattttcc aatatatacc
    35041 ctatttcttc taaatcaact aagtaactta tgacagatac taacgaagat ttaaaaaaat
    35101 gatactcttt ataattattg cttaaattat tgttatttat aatgtttttt aataaaattt
    35161 ctaaagattt cggttctaca agcaactctc ttatttgata taaatatttt tttaaagcat
    35221 tcaaatgttt ttctattaat ttataagaat cttctttcga tataacttgc ttgccatgcc
    35281 ctaaaactaa gtactcaaaa tctatatttt ttaatttttc taatgaattt atttgttctt
    35341 gtatatcata tagaaacaag aaatcgtatt ttgataaaat ttcatctcct atcaataaat
    35401 cgccaacaaa aatcacatta tccttcgtca aaacagctat actaccaggt gtatgaccct
    35461 gaaattcaat tatatcaaac atttcattgt ttaattcaaa ttttccagct tctataaatt
    35521 tatctatttt tatatcatcc aacattttat tttttaagat attatccata aatacattgc
    35581 tctttccccc aacaatatac tttgaaaaca attctggatt ttctatatat aatttatcgt
    35641 attcagatga cattatacac acatctttat aatattcttt aaattgatta caagctccat
    35701 agtggtcatc atgaccatga gtatttataa tatatctaac ctgtatatta ttttcatcta
    35761 atactttatt tactctccta ggtcttgaac cacataaccc tgggtctatc ataagtgctg
    35821 tgttatcttc aaatacatat attcctgtat tcgtgccacc ttttataaaa aaggtatttc
    35881 cttttacttt tgtaagattc accttcttca cctcattttg acaatattta tgatacaatt
    35941 tattacttac taatataaaa ctatacaaga acaatccttt ttattctatc tatagttctt
    36001 tttcttattt tgtattcttt agatatcctt attttcacat tatatgctaa atttctataa
    36061 agtaatgact ctataaaata ttcaactata cctctatccc taaagtctat atctatattt
    36121 ccacttgaat aaatatttga gtctaatatc ataagctcat caaaaaagct taatctctta
    36181 gatttactta aataatcttt atttggaata aatctatcac aataatctat cctgtaattt
    36241 actacttcat catttatttc aaatccatat tgctttttca ttaactctct atagttatta
    36301 tttttctcaa taacattatc taaattttta ttataatcct cttttttcca atgtccaaac
    36361 atcctacaat ttaatggtct aacttcatat attaaacatc tattattagt atctttaaat
    36421 ggacatgggt tctttcttgt atactcctca aaataataat ctaatatttt acttatacag
    36481 ctttttttta aatcaactct atcttcaaga taacaaaata tattcaaaaa ctcaattaaa
    36541 tttataccta ctgactccat acaacaattt ccacatccag aacaatttcc tactggcaag
    36601 gacttatata catcatttag tttgtcaaag agcttatttt taatggaata atctatacaa
    36661 tttaaaatat ctttattttt tatactagtc attattatta ctccttgtta taattattaa
    36721 gttaatacaa acaattatta taacatattt tttaaattta atcgcatatg gaggtatttt
    36781 atgaatagat atacaaaaat aattaatatg atgggaagtt attacacaaa agactttgaa
    36841 aaagaaaaaa agaatgtaat aaaagttaga gaagttaaag aagatacagt tagaaaattt
    36901 ttcttacaag gtgactgtga agttcttgta gtatttgaag acactgggaa agaaatactt
    36961 attgatgact tttctcctga agaagatatc aaaaaatatt taggagcaaa atttataaat
    37021 aaaaaaagat agttatcaaa aataattcta aaattaaaat ttaataaatg tacagttata
    37081 attctatata attatagtta aaagttatct tttattgctt ttttagactt taagatagct
    37141 ttttttctat tttttgtaaa ataattccat aattcacatt aataattcac aaaatgatat
    37201 aatataacaa atagataaat ttttaaattt ctaaatacat aattaatatt ttgcgaggtg
    37261 attttatgca aatttatttt agagttaagg ctgttggcaa acgcaaacct atgctagaac
    37321 ttaccccttt tgatgtatct gacaacatca attgcctaaa agaagctatc tctgaaattg
    37381 tatctaaaaa tgttcttgaa tataatgaga aaatcccaga aaaatcaata ataaacttct
    37441 taactaatga agaaattgaa tctcaagctg atattggaaa agttggattt ggctctattt
    37501 acaatgagaa taaacaatct gtagaaaagg caatagaggt agcgttacag gcatttgaag
    37561 atggaatcta caaagtgctt ataaatgaag atgttattga aaaactcgat tcctctataa
    37621 atctgaaaag tggagatata tttactttta taagacttac cttgcttgct ggaagaatgt
    37681 tttaaaataa ataatttgga ggtacataaa tgttagaacg tactagagta gaaaaaaatc
    37741 ctaaaataat tgaaaatttt aaaaataatt ttactaaatc ttcttcaaaa cagtactacg
    37801 acttagcaaa gtctctttgg gactgcatag aaaatagttc atactattat agagaacctg
    37861 aagacaaatt cttaaatatg ataaagaaat actacaattg ccactactac gaaattaaaa
    37921 atatggacga gctcctttct ggacctttaa aaaatgcatt agaattaata tttacttctg
    37981 aacaagtaga agaactttgc caattaatta aaagaaagat ggattataca tattcaggag
    38041 gatattatcg taaagggtat cgctcaaata aacttgtgga ttattttaga ggtattataa
    38101 ggtttatttc aaactatgtt gatttaattt attatgattt ttcagttata gattatctta
    38161 ctcttccaaa taaggtcttg tactatgact ctataatgag tgataaaata gcactagaaa
    38221 tagacaaagg aaatcaaaaa gtaataagtg ctttagaaga agtaatattt ggagaaaatc
    38281 aaactgctct acttacaaga caaatgataa ttggtatcat gaagagtcat agtgataaat
    38341 gctatgaaat gctttctaaa cttcttttgg cagccaaaca acaagaagga cttagacagc
    38401 aaattgtaga gagtttagat gagggtacaa tttctgcatc aatatacatg ttaaaaacta
    38461 ttttggacaa caatttagag cgatttagtt ctgttataag agccttggat acatggacag
    38521 gacttggttt ttcagaccaa aaacctggaa taatacgtaa atgtttagaa ctttcatata
    38581 aatcattgac tgatgaaaag ttccgtatag aatcaattaa tagcaatgat aatcttgaaa
    38641 tttattttgc cttatgggct actgcaactt acaacatata tgactcttac tctcttattg
    38701 aaaacttact ttcttgtcag gaaaaatata aaaaacttgt agctctttac tttttatcgc
    38761 atacagaaag tacatatttt aaacattcta tagcatctaa aaacattaag ggtgatgatt
    38821 tagagatact agcatgggta attacaaatt tctatgtaga aggttctgtt ggctactact
    38881 atagttggca aaacagagaa actaattttg acttgtcaaa cactcctatt gacaaagact
    38941 ttgatgctag aaaagaacaa tttgaaagtt taaaacatac tttagaaatt ttaaattcaa
    39001 agacaaaatc attttcagga agtgtatttc catggacttg gattgaaatt tcttctcatg
    39061 aaatacttaa atgtatgatg actttaacag catacgatat gaatgctcaa tttatagatg
    39121 tgcttatgga aaattgtcat cttatgagtt cagatttaag agcttcactt atagtcaatt
    39181 ttgtaaatga accaaagaca gatagacaac gtgaattttt attggaatgt ttaagtgata
    39241 agagtgtttc caatagagaa acggtattga gtctacttag aaagcttgag ctaacagatg
    39301 tagaattaga taagataacc aatctattgt ctttaaagac aagctctatt agacaaacag
    39361 taataaaaat tttacttgaa caagatgatt caaatttgga aaatattgct tcttcactga
    39421 taaaatcttc aaattctcaa aaatgccttg gaggtcttga aattgtaaac ttattaaaag
    39481 acaatactgc tagacaagaa ctatataata agcttgtttt acttatagaa gatattgata
    39541 aatctaaaaa gaatacatct caagttcaaa tactaattga taatttgtta ggtaaagcaa
    39601 aaaatgatta ctgcaaagaa aatggttttg gaatatataa ccctgaaaac aaagttcaaa
    39661 ttccagaaca atttgatttt aaagatgatt ctaatagctc atcaaagctt aataaaatta
    39721 tctcaaatat aagtttatct actcgtgagg attctgtttc tgtagcaaca aaaaaagaag
    39781 caaaaaaaat tctcgatacg gatataaata aaataataaa agtttatgaa aaatttgatg
    39841 agcttattac tgaaaatgca gattatgaat atgaagttga aagatggtca ggtaatgtag
    39901 acaaagtact tttaggttat tctacttata acttgactcc tattaaatat aaagtttcta
    39961 atgatactct tgataattat ccattagcag agctttggag agaaactagt aaaaagcttg
    40021 acttagatta caaattaata cttgatattt tattttatag tataagtaca tgtggatata
    40081 atgaaacaga aaaaagttgg ttttcatcta tatattcaaa tgtccttgac tctaaaaaac
    40141 aaaataaaat atatacaaaa cttgaaaaac ttaaatttaa tggacttaca agaaaacttt
    40201 taagagtttt actaaatgag tttgaccata aagaaatatt taactattgt ttagaaatat
    40261 actataaact tagaaactta ttgactatag aacaatgtaa aaaacaaaga gttgaattta
    40321 ctaaaaacta ttacagacaa aatgaatact gccctgcttt aaatgcccct attttaaact
    40381 attggcttga taaagcacat tcgtttattt atgatgatat ttcttttact aagtttttct
    40441 acactacgtt ttcaaattat cagttgctag aatataagtt tcctttctat actagcataa
    40501 atgtgtttgc tcgtgcacat gaattaggat taatgactga agagcaagtt aatagagaaa
    40561 tgataagtgg atacaacgca tcaaatataa taagaacatt gacaaatcct agatgggctg
    40621 gcgacacatt agaaaagtac ccttggctta aagataattt aaaaactgtt acaaaccgaa
    40681 ttatagaaat tgaatcacgt agaggtgata tgccaacaga ggtgtctcat ctagctaata
    40741 atatacaata ctttgaaggt ataaattatt ttgtaaatat tttggtcgct cttggtaaag
    40801 aaacgttcca gagaggatat tcatatggta gcaattattc aaaaaaagat gttttaagtt
    40861 ctctacttaa aaattgctat cctactaaag aagatgactc aaaaaaatta aaaagtttac
    40921 ttaaaaatac cgacattact gagttaagat tgatagaatc tgctatgtat gcccctcaat
    40981 gggtaaacat aattgaaaaa tatttaaact ggaagggtct gaaaagtaca atttggtact
    41041 tccatgcaca tataaatgaa ggcttctctg cacaaaaaga atcagaggtt gctctattct
    41101 cccctatttc accacgtagt ttcattgatg gtgcatttga tgtagattgg tttttagatt
    41161 catataaaac tattggggaa gaaagattca atatacttta caagtcagct aaatatataa
    41221 ctagtggtgg taactctcat agacgtgcac aactctatgc tgatgctaca cttggtaagc
    41281 ttgataaaga catgttgatg aaagaaattg aaacaaatag aaatcaagat aaattgagaa
    41341 gtttctcttt acttcctatg aaaaaaggag acctaaaaga agcaactttc cgttatgaat
    41401 ttattcaaaa gtttgctaaa gaaagcaagc aatttggtgc acaacgtcgt gaaagtgaat
    41461 caaaagcttg tactatagcg ctagaaaatc tagctagaag tgctggattt ggagatgtaa
    41521 atcgtatgat gtgggctctt gagactgaaa aactaaatga agttgctcat ctatttaaac
    41581 caaaagatat tgatggtact tcaatttgga tagatgttga tgaaaacgga aaagcatcta
    41641 ctaaagttca aaaaggcaac aagtctttaa agagtatacc aaaagctatt gctaaacatc
    41701 catatgtact tgaacttaaa tctgtccaaa aagatttaaa gagtcagtat tctcgtgcaa
    41761 aacagagttt agaacaagct atgaaaaatg aaatagtatt tacagttaaa gaaattgcca
    41821 atatctataa aaatccagtt atctgccctt tgattaaaaa tctagtatgg gtatgtgatg
    41881 ataatattgg atatgtttat aatgataagt ctaagttctt tatttgcaat atagaaggtg
    41941 aaacttataa gttgacggca aaaaataaat taaaacttgc acatccagtt catttgtttg
    42001 aatctggtaa gtggagtgag ttccaacatg atttatttag taagcaaatt gttcaaccat
    42061 ttaagcaagt attccgtgag tattatagaa taaacagtga tgaattatct gaaaaaacta
    42121 tatctcgcag atatgctggt caccaaattc agccaaagaa aactgtagca cttcttagaa
    42181 atcagctttg gactgtcgat tatgaagagg gattacagaa agtattttat aaagaaaata
    42241 tagtggcaaa gatgtttgca cttgcagatt ggttttcacc agcagatata gagcctccta
    42301 ctattgaaac agtagaattt tttgatagaa aaacttataa aagtttagaa ttagcttcta
    42361 tacctccaat tctattctca gaagttatgc gtgatataga ccttgttgta agtgtcgctc
    42421 atgctggtgg tgttgaccct gaaactagcc attctactgt agagatgcgt atagcaattg
    42481 ctaaagaact tttattatta ttaaaaatta acaatgtcaa ttttgaaggc tctcatgctc
    42541 ttatagcagg taatttaggt gagtattctg tgcatatggg ttctggtatt gtacataaaa
    42601 aagggatggg tgctttgaat atacttccta tacattctca aagtagaggt aagatattcc
    42661 ttccattcgc tgatgaagac cctaaaactg ctgagattat gtctaagata ctattacttg
    42721 ctgaagatag taagattaaa gaccctagta tcttaagtaa tttataagta taaaaactat
    42781 ccctaaaata tattggactt tcttaaaaaa aattagaaag tccaatatat actatactgt
    42841 aatttatata gattaaatca taattacaaa taattttta
//
LOCUS       DAEPID010000031        40899 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.031, whole genome shotgun sequence.
ACCESSION   DAEPID010000031 DAEPID010000000
VERSION     DAEPID010000031.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 40899)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 40899)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..40899
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.031"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            complement(129..1238)
                     /gene="ugpC"
                     /locus_tag="KR257_001809"
     CDS             complement(129..1238)
                     /gene="ugpC"
                     /locus_tag="KR257_001809"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003242648.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sn-glycerol-3-phosphate ABC transporter
                     ATP-binding protein UgpC"
                     /protein_id="HBH0030513.1"
                     /translation="MSEVILKNISKLYSNGFNAVKNINIDIKDKEFIVLVGPSGCGKS
                     TTLRMIAGLEEISEGELYIGDKLVNDIEPKDRDIAMVFQNYALYPHLSVYENMAFALK
                     LRKLPKDEIDKKVKEAAKILDLLPLLNKKPKTLSGGQRQRVALGRAIVRNPKVFLMDE
                     PLSNLDAKLRTAMRTEITKLHQQLGTTFIYVTHDQVEAMTMADRIVVMKDGVVQQIAT
                     PQDVYDYPANIFVAGFIGAPQMNFIDVILIEENDEIYAQNEHIKLKLNKEKHYDLIKD
                     NYINNEVVIGIRPEDIHVEDTFIKSNPDTCFKSRIEIKELMGAETYAHLKLGENTITI
                     RFDSKNRINVGDDLTLSVDNSRVHIFDKETTLAIR"
     gene            1672..1848
                     /locus_tag="KR257_001810"
     CDS             1672..1848
                     /locus_tag="KR257_001810"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0030514.1"
                     /translation="MNLKKKEKIVKPVLKKLTEIVLNILSKKILNYAIYAISVLIVTK
                     VVINIDLYISILYY"
     gene            1949..2686
                     /gene="cas6"
                     /locus_tag="KR257_001811"
     CDS             1949..2686
                     /gene="cas6"
                     /locus_tag="KR257_001811"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416586.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CRISPR-associated endoribonuclease Cas6"
                     /protein_id="HBH0030515.1"
                     /translation="MSRISIFMESCNGKFPNENSMLSVSFIKNILNAENKDFAKNIFN
                     YGEERKNNKQIKDINTAIYIPNLIRSKNELLVDGDIIFNISFYNYSMFSKLYNGILKV
                     KELEYKGYRFKIKNIKIHKEHEIKENGVIFKTMSPIIVKNKEGKYLDVEDSNYIECLN
                     YIANLTLESIRGSGLRKPLEFIPLNFKKRVLKEKIRGFKEREFYYINAYAGTFFLKGN
                     MEDLNALYKMGIGYRRTENAGMVDILK"
     gene            2691..4166
                     /locus_tag="KR257_001812"
     CDS             2691..4166
                     /locus_tag="KR257_001812"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890662.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0030516.1"
                     /translation="MREIKAKFYRSGDIVRDIGIVYFCELLMDLKNELEKNDYKLKFT
                     CELNRNYLSLESAEYIDPKYISDYILENQLFKVFKNGKKETLEKIFSNIDNLTYVNFI
                     EELDKSSATEKQKEGIKKDFKNRRFPYVRNSGKYGLNTSLENMEKNVKRIVDIVIKSN
                     IEIDEIDKLDLKQYEEKDSVCNVCNINKTTKLDIDLRERKDSKYNFLFRGAEKSGFKR
                     SGQVESNICFECEFFNLMCLLYINLKRPMVFAYTNDLRELAFLNHKIMLKRKMYSDKS
                     FYKKLLHEKISSIRLYRIDIDTNKGIILKFDSIIEYKELLKKIELIDIIDNYNFSREP
                     MNTRNLGKKMINNGNLSNLKELLLDNISVLRQLTGTSREMDFVSSSYNIGLYIKLCWI
                     VDGREEYKMKNYIESNLIYSRVGKDLFNKMTDESRRKNFSMKVIQLLKSNDRTQLFQT
                     IMHVLVSNGILIGEGFVEGLMQSSELELNTNVGLFIQEIMK"
     gene            4186..5202
                     /gene="cas7i"
                     /locus_tag="KR257_001813"
     CDS             4186..5202
                     /gene="cas7i"
                     /locus_tag="KR257_001813"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416591.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type I-B CRISPR-associated protein
                     Cas7/Cst2/DevR"
                     /protein_id="HBH0030517.1"
                     /translation="MNEKRVKGVTLTILTESPVPLSYDQGYGNYTPIKKEQYRDKVHA
                     KTSIATITYDLRRILHQEYGWNLSNIVFGKKGNIYPSIKKNVGCVDENGLETDVFGYL
                     IPLKEKGSISKASPLRIIPFRSLNSYRGSTQLITNRGFLSSEFGRKYYDEREENEVLR
                     DENFPTTQALAIEETLSDYYVYTITLELDRIGVVEVEEDGKLLLPEERKFMSKELREK
                     AVKDILDAITVFTRNIKHSSVLLKPLAVMGGAFDKVVPFFWDDVDYNADSGEINLEGV
                     IETIESYSLKESNTILAINDRLKISNKKELNKFNLSKYPVKEIKNLADRLEIGEDNMW
                     YLKE"
     gene            5218..6015
                     /gene="cas5"
                     /locus_tag="KR257_001814"
     CDS             5218..6015
                     /gene="cas5"
                     /locus_tag="KR257_001814"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430916.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CRISPR-associated protein Cas5"
                     /protein_id="HBH0030518.1"
                     /translation="MKVLQCKLKQPTAHYRDPKVFQNEYISTLNLPSKTTIMGMITYL
                     CDRRLNSDIDIGIIGTHHHRELEFSRGENIDFWNEYTNMRKGKDKEKFLLQGNYYDYY
                     KEHKAQNSILNYEVLKEVELTIFISCKDDEELEFIRKKLESPCKYANLGRKEDFVIPS
                     EKGCFVKEVELKEVIPMNTRDAIKENIKLKNTYVRVDLRDKENVETIINQGVLIALPY
                     KYKDLEANRDDRVYEFCHYIYVDNDGIYPKNIKVNVCIDTKEVFTWL"
     gene            6042..8450
                     /locus_tag="KR257_001815"
     CDS             6042..8450
                     /locus_tag="KR257_001815"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454738.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CRISPR-associated helicase/endonuclease Cas3"
                     /protein_id="HBH0030519.1"
                     /translation="MKNIMQKEILAKSYNLRTNQQEQTLVEHIKDLFEVLESILELNL
                     YSDKDVEILKICCALHDLGKINSIMQQKMEINNKISYSCSEEERKKLESDKKSLKKIA
                     RHNIFSGAFLKDILEKMNLSEEDKLYIYKSIMLHHGNYEDYMRLSISKVQEEIYEYIE
                     KGILEKEEFNLKDIESYINSILNVDFKFGEDVLDYDYIDKLSESMFIDSDYNNGQIDD
                     SVLNYRKFKYILYKGMLNLIDHSASSRQKGIKFYNDFTDEEIDNMILNEIYKSQGNLE
                     KNNIEFNTIQKRLRELSGRNVLTVAFTGSGKTAADYRKTFKRKFFLVPNKISAESFYR
                     KNIFQNKNDLDTRSSNDYIGLLHGDINLYSENEDNGEHDFVLTLRDIDLSINFCKPCV
                     IATVDQLLLSMFKFPGYEKIFAAVKNASITVDEVHLLEPKMFLILIYFMQFACKYLDV
                     DFHLMTATLPKSYKEQMINKGIIFQEESNENVTDKGEIVFIESNKEEEICEGKDVKVS
                     FIKEKEIKSIVEDALENKQKILIIKNTIDSVNRTYEFLKENLSDKYGGVDIDVLHSRF
                     KFKDKKEKYSKILNGEGDIWISTQSVEISLDLDFNIIISDLATMDSLIQRMGRCNRNN
                     KYEYGNFYILPSEDKIYDNKLKNTTKNILKDILKTNSIFTMGIRKTILDDYYDNSVVK
                     KYFEENFISCDKEIKNIYGINKEIFDGLDLIFNFEPYKNIVDSKKEAAKIFRDVDVSY
                     KIILEEDFYKEDRELQQDSIQVSGFIFNRLYYYGLISKVEGYMVLKSSSKFEYNSTVG
                     LILK"
     gene            8892..9839
                     /gene="prmA"
                     /locus_tag="KR257_001816"
     CDS             8892..9839
                     /gene="prmA"
                     /locus_tag="KR257_001816"
                     /EC_number="2.1.1.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454737.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L11 methyltransferase"
                     /protein_id="HBH0030520.1"
                     /translation="MNNWIEVTIKTTTEAVEPITNILYEQGAGGAVIEDPKDFLFQKK
                     NELDWDYVEEEVFKKNEEDDVLIKTYVSEEKNVMEFVEIIKQKVLGLKDFGIDIGEGS
                     VSLDQVNEADWANAWKAYYKPTKVGQRVVVKPTWEDYAMQEGDLIIELDPGMAFGTGT
                     HETTSMCIRELEKYVNKDSKVFDIGCGSGILAIAAAKLGAKEVVAVDLDEVAVKVAKE
                     NVLENKVEKSVSVMHGNLTDVIKDKADVIVANIIADIIKILAKDVQNFMKEDAIFISS
                     GIILDKVEEVKESLIENGFEIVEVQKLGEWSAIVSKLKK"
     gene            9858..10616
                     /locus_tag="KR257_001817"
     CDS             9858..10616
                     /locus_tag="KR257_001817"
                     /EC_number="2.1.1.193"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416604.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="16S rRNA (uracil(1498)-N(3))-methyltransferase"
                     /protein_id="HBH0030521.1"
                     /translation="MDRFFVEKNNINLQDKTCTIEGEDVKHISKVLRCKLGEKLEICD
                     KNNNEYICEIMNIDKSIVNLEILEKVDINRESELKVRLYQGLPKAPKMEMILQKLTEV
                     GVEEIILVQTKRSVVKVDDKKEDKKFERWERIIYEAAKQSKRGKIPKLRGVLSFKEAL
                     EDMKKNNVNICPYENERTVSIKHALKKCDSNIDSVGIFIGPEGGFSEEEIEQIQKNNC
                     NVVSLGPRILRTETASVVASTIALYELSDLGGEK"
     gene            10618..11916
                     /gene="mtaB"
                     /locus_tag="KR257_001818"
     CDS             10618..11916
                     /gene="mtaB"
                     /locus_tag="KR257_001818"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454735.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA
                     (N(6)-L-threonylcarbamoyladenosine(37)-C(2))-
                     methylthiotransferase MtaB"
                     /protein_id="HBH0030522.1"
                     /translation="MKKVAFYTLGCKVNQYETEAMLELFEKDGYEQVNSEEYADVYVI
                     NTCTVTHMSDRKSRQYIRRVKKKNPDAIIAVVGCYSQVSPEEILDIEEVNLVMGTNDR
                     RKIVEEIKKINSSKKVSTVDDIMKVKAFEEIEISQTNGKTRAFMKIQDGCDRFCTYCI
                     IPYARGRVRSRDIDSIVDEVKKLANNGYKEVVLTGIHVASYGKDLKDRDIKLLDVIKQ
                     INQIEKIERIRLSSVEPILFTDEFVNEVLKMDKVCPHYHLSLQSGCDETLKRMNRRYT
                     TLEYKTIVDRLRSKMPDVAITTDVIVGFPGETNEEFKKTYEFLKEIELSQMHIFKYSP
                     RKGTPAATMENQVDPQMKHFRSEQLLNLSKVNFNKFATKFIGRELDVLFEQNIEGNKY
                     EGLTSNYIRVVVESDKNIQGQILKVKINDVKDEYVEGILL"
     gene            11959..12309
                     /locus_tag="KR257_001819"
     CDS             11959..12309
                     /locus_tag="KR257_001819"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430911.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="histidine triad nucleotide-binding protein"
                     /protein_id="HBH0030523.1"
                     /translation="MDCIFCKIANGEIPSTKVYEDDRVLAFNDLNPVAPYHILVVPKK
                     HYDSLIDIPDKEMDIVSHIHVVINKIAKEKGFDQTGFRVINNCGSDGGQEVKHLHYHI
                     LAGKKLPNYEAGQN"
     gene            12472..12651
                     /locus_tag="KR257_001820"
     CDS             12472..12651
                     /locus_tag="KR257_001820"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416618.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S21"
                     /protein_id="HBH0030524.1"
                     /translation="MSEVRVRENETLDSALRRFKRQCAMSGIMSEVRKREHYDKPSVK
                     RKKKAEAARRKNAKK"
     gene            12681..13124
                     /locus_tag="KR257_001821"
     CDS             12681..13124
                     /locus_tag="KR257_001821"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430905.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GatB/YqeY domain-containing protein"
                     /protein_id="HBH0030525.1"
                     /translation="MSLKQKLQEDLKSSMKNKDTVRKSVVTLIRASIKQYEVDNRVEL
                     DEDGIIDVIAKQLKQRRDALVEFEKAGREDLIKETEGEIEVLKEYLPQQLSEEELEEI
                     VKSTISEVGATSMKDMGKIMSVIQPKVKGRADGKLINKLVKQNLQ"
     gene            13235..13732
                     /locus_tag="KR257_001822"
     CDS             13235..13732
                     /locus_tag="KR257_001822"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416623.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tryptophan-rich sensory protein"
                     /protein_id="HBH0030526.1"
                     /translation="MIISVKEIRNFLINIFIPLIIGYLSSILTMIISGTDISTYYLQL
                     TKPSFAPPAFIFPIVWTILYILMGISSYLILRKGYNLPKVRDAIFYYGLQLVLNFIWS
                     ILFFGFGLRFTALIDIIIMILVSIIMISKFSKIDKRSGYINLIYLMWLVYAGFLNYFI
                     WFINK"
     gene            13925..14488
                     /gene="raiA"
                     /locus_tag="KR257_001823"
     CDS             13925..14488
                     /gene="raiA"
                     /locus_tag="KR257_001823"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430900.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribosome-associated translation inhibitor RaiA"
                     /protein_id="HBH0030527.1"
                     /translation="MQIIVSGRQMKLTDGIKGYVDGKLSRLEKYLDPESEVKVTVSAK
                     KDRQKVEVTIIPINGQIIRAEDVEDDLYAAIDIVCDKLSRQVVKYKTKVKDKVQNNKS
                     IRFENLDFIDNSSEFDDYDYDDEEDENIVIERRKKFNVKPMSSEEAILQMELVGHNFY
                     MFRNQDNFEINIVYKRKAGGYGLIEQD"
     gene            14701..14937
                     /locus_tag="KR257_001824"
     CDS             14701..14937
                     /locus_tag="KR257_001824"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890653.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YabP/YqfC family sporulation protein"
                     /protein_id="HBH0030528.1"
                     /translation="MLEISTDLQVNQPVITVTSNTFISIENYLSILEYEVDLIRIKTK
                     VKTIKISGDKLSLKYITDSEIGIKGIIYNVEYVD"
     gene            14950..16293
                     /gene="yqfD"
                     /locus_tag="KR257_001825"
     CDS             14950..16293
                     /gene="yqfD"
                     /locus_tag="KR257_001825"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890651.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sporulation protein YqfD"
                     /protein_id="HBH0030529.1"
                     /translation="MISFIRGYYVIVVEGVGLEQFLNHLIRNGISVYNVTRIKNTKME
                     FHIDRQDIKEFKNVYRGSKFDIKVKQKTGVPFIIKRVYKHKGMWICALVSLFLLMSTS
                     QFVTDVYIQSPEGIKKEALRNELYKVGVRPGVYKKSIDRKEVRDHMMSKFNDVAYLSI
                     NVKGTNIFVTVTKKAESLKSTDQSNYCNVIALKNGIIEKVIPRSGKSVIKSGDIVQKG
                     DVLLNGANTKSIPEVWASTFYESTKKASYVDTVNKKTGEKKNIYTLSFYDKEFTMRKN
                     IKYKDYVVENKEKKLSIGNYTFPIKIKTSTFYETKKVEVKRNKEELKKELSEKALKEL
                     EYIIPASARIIDVKHNFKVNKNMLEYLITVQTSENIAKIYPLSKSEAERFIKEESKPD
                     EGEEEVPSNPEKRPLNDIRNEFDEDNKDNKDQNNSDENNSNQNSNNSQNNNSNNN"
     gene            16232..17347
                     /locus_tag="KR257_001826"
     CDS             16232..17347
                     /locus_tag="KR257_001826"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430896.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PhoH family protein"
                     /protein_id="HBH0030530.1"
                     /translation="MKIIVIKIVIIVKIIIAITTNKIKLKILGGLIQLIIQKKFTIAD
                     GNFERELFGNFDENVKLIEKTLNIDVILREGNIILIGEEKNVDSALKLMNELHQTVSN
                     GKHLDKQSISYSLSLLLEGSEQKIKELEGTIVITQRGKAVQPKTLGQKEYIKLIENND
                     ITFGVGPAGTGKTYLAVAMAVKAFKRDEVSRIILTRPAVEAGESLGFLPGDLKDKVDP
                     YLRPLYDALFEMLGADKFNKYLERGTIEVAPLAFMRGRTLDNSFIILDEAQNTTSEQM
                     KMFLTRLGFGSKAVVTGDVTQTDLPQNKKSGLIQATEILKGVPGIGSIMLTDRDVVRH
                     ELVQRIIRAYEKHDKREEFKKEERKKAKMQEKTFKRK"
     gene            17404..17865
                     /gene="ybeY"
                     /locus_tag="KR257_001827"
     CDS             17404..17865
                     /gene="ybeY"
                     /locus_tag="KR257_001827"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416637.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="rRNA maturation RNase YbeY"
                     /protein_id="HBH0030531.1"
                     /translation="MDLILDDRQDKLEVSEELIEKIKDIIIECLDYEGYDDNYEVSLS
                     FVDNKEIHELNREYRGVDRVTDVLSFPLLSDDFEDVELEEESLGDIVVSLERALEQSI
                     EYNHSFEREVCFLICHSMFHLLGYDHDTDENTKEMREKEEHILNKLNITRE"
     gene            17871..18590
                     /locus_tag="KR257_001828"
     CDS             17871..18590
                     /locus_tag="KR257_001828"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416641.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="diacylglycerol kinase"
                     /protein_id="HBH0030532.1"
                     /translation="MKPEKTRQGIIKAFNAAIEGILYTFKFERNMKIHYLGSVAVLII
                     SLFFNFSKLEMIMLLMSICLVVVAEMFNTAIEKAVDLVTDEYHVLAKIAKDVAAGGVL
                     VAALNSVVVGYILFYDKLTDISGILIYKIRESELHITLICILLVLIAVVVVKALTSTG
                     TPLKGGMPSGHAALAFAIATAITLMTERVVASTLAYIMAVLVAQSRIEGKIHTFWETI
                     AGALLGVLIAILVFQLGMFYN"
     gene            18709..19110
                     /locus_tag="KR257_001829"
     CDS             18709..19110
                     /locus_tag="KR257_001829"
                     /EC_number="3.5.4.5"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890647.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cytidine deaminase"
                     /protein_id="HBH0030533.1"
                     /translation="MDNIELLRLAEDARQHSYAPYSGFRVGAALLTKSGKVYTGCNIE
                     CASLGGTNCAERTAIFKAISEGDKDIYKIAIASDNSENNEQTYPCGICRQVIIEFGSD
                     IKIITGYTKGEVFEHSIKDLLPNYFSGNDLK"
     gene            19174..20067
                     /gene="era"
                     /locus_tag="KR257_001830"
     CDS             19174..20067
                     /gene="era"
                     /locus_tag="KR257_001830"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897628.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GTPase Era"
                     /protein_id="HBH0030534.1"
                     /translation="MFKSGFVSIVGRPNVGKSTLMNNVVGEKIAIMSDKPQTTRNTIQ
                     AVYTDEEMQIVFLDTPGIHKPKNKLGEFMVKAATEAFKNVDLILFVVDDSKKIGPGDR
                     KIIEDLRSVKTPIILVVNKIDQLDQKDELFDIIKMYDREGIFKEIVPISALKGKNTDT
                     LIKVIQNYLEEGPKYFPDYMITDQPERVLIAELIREKVLHYLNDEIPHGVAVEIEKMK
                     ARNDKEIVDVSAVIYCERDSHKGIIIGKNGRKLKGIGKSARQDIELLLGSQINLQLWV
                     KVKENWRNLQNYINNFGYNDK"
     gene            20079..21458
                     /gene="mgtE"
                     /locus_tag="KR257_001831"
     CDS             20079..21458
                     /gene="mgtE"
                     /locus_tag="KR257_001831"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416647.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="magnesium transporter"
                     /protein_id="HBH0030535.1"
                     /translation="MDRKLDASQDLLYEVKSLIDNNKVLELRELIEEYHIIDIFDIME
                     NLEEDMKIQLFEVLPLDMASSILEEGSVEFFISILSKLDVEHSKNILELMSLGDMADK
                     LSELEEEEREHIINLLNQENADYVKELLFYDEDSAGGTMTTGYISINKDMTALEAIDH
                     MREEAEEAETIYYIYVVDDEEKLVGVLSLRELIIARDANIVEDLMSENIISVYVDEDR
                     EEAVRLVSKYNLIAIPVVDRQEKLKGIITVDDIIDVMEEEATEDMYKFAGSSEHEREV
                     AEKENPTLREQIISALRGRLPWLIITLVGGLLASLILSNLDYIMNPVYAPLVFFIPVV
                     IGMGGNIGTQSSSVTVITLSNKDLNFSNVVREGIVGIITGLLCSIITGIVIYFVMRKL
                     DIVLIVSISLFINMVLGATIGAFMPVLLKKMDADPSTVSSPIISTALDITGIAVYFII
                     TTALLSKIV"
     gene            21531..21686
                     /locus_tag="KR257_001832"
     CDS             21531..21686
                     /locus_tag="KR257_001832"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416649.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YqzL family protein"
                     /protein_id="HBH0030536.1"
                     /translation="MNNISWEVFKKTGSIDAYLYFCDCKNIHEEIEEVREKKEDDDNP
                     EHPGDST"
     gene            21652..22425
                     /gene="recO"
                     /locus_tag="KR257_001833"
     CDS             21652..22425
                     /gene="recO"
                     /locus_tag="KR257_001833"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430885.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA repair protein RecO"
                     /protein_id="HBH0030537.1"
                     /translation="MIILNTQGIVLKAIRYKESDIILTLFTRKLGKVSAIAKGAKKNK
                     SSLLSSSQLFSYSNFTLKKQGNMYKVTQSEIIKSFYNISYDIEAFSYATYITKLVENS
                     ILENQTNNRLFILLAQTLYLYTQDNTDNRFITAAFELKFLDYIGFKPIVNKCINCECK
                     ILQNSVFNIYEGGILCSKCSKLFDNNIKLDLTTISLMEYVLRNDILTCSKAKVSKYIT
                     HELENILDKYLKVYVDNINFKSLHVLQSVKNNKGVDNDE"
     gene            22418..23017
                     /locus_tag="KR257_001834"
     CDS             22418..23017
                     /locus_tag="KR257_001834"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890640.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4342 domain-containing protein"
                     /protein_id="HBH0030538.1"
                     /translation="MSSNITIEMVDSVFERVPGATYAEAKEALVMCNGDVIEAVIYLE
                     NKKNTCNCKAKSAKETMEEVFGKDGENIKFQLKELLRKSSVVRIIVEKDGKTMMNIPL
                     TVGVVGLAFVPLATLVGLSAAVISKYRIKVQNEEDGEIVDLGELNEEKLHVLKNMITN
                     AAKDVKDVVVDKKEDDKDVTADLMKEESEKNKEDEDENK"
     gene            23177..24055
                     /gene="glyQ"
                     /locus_tag="KR257_001835"
     CDS             23177..24055
                     /gene="glyQ"
                     /locus_tag="KR257_001835"
                     /EC_number="6.1.1.14"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416656.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycine--tRNA ligase subunit alpha"
                     /protein_id="HBH0030539.1"
                     /translation="MNFQEMILALQKYWSKQGCIMMQPYDIEKGAGTMNPNTFLRSLG
                     PEPWQVCYVEPSRRPADGRYGENPNRLYQHHQFQVILKPSPDNIQELYLESLKEIGID
                     PSEHDIRFVEDNWEAATVGAWGLGWEVWLDGMEITQFTYFQQVGNIECELETGEITYG
                     LERLAMYIQEVDSVYDLKWNDKITYGEVFNKAEYENSMYAFELCDADMLFNLFDIYEK
                     EALRLMENGLVIPSYDYVLKCSHAFNTLDARGAIGVSQRASFIGRVRNMAKTVAETFV
                     KQREEMGFPLLKDGDK"
     gene            24055..26121
                     /locus_tag="KR257_001836"
     CDS             24055..26121
                     /locus_tag="KR257_001836"
                     /EC_number="6.1.1.14"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903195.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycine--tRNA ligase subunit beta"
                     /protein_id="HBH0030540.1"
                     /translation="MKNYLLFEIGVEEMPSRFVGSTLEQLKNNLSKLFDENRIAFDKI
                     NAYGTPRRLTLVVEGLSDRQSDLEEEIKGPAKKIAVDAENNLTKPALGFIKSKGLSES
                     DIYFKQVGKEEYIFATIKQDGKETSEVLKDILPETIKSVVFPKAMRWGGKNLKFARPI
                     RWIVALLNDKVLEFDLEGIISSNVTKGHRFLGESTIEVDSIEDYFEKLEKNYIVLDQN
                     KRKEMIRKQCIEVANSLGGEVEFDEDLLEEVTYLVEYPTAFYGEFDVDYIKLPKEVVI
                     TPMKQHQRYFPVLKEGKLLPNFIAVRNGDSYRIDNVKAGNEKVLEARLADALFFYRED
                     TKRNLESYIEKLKTVVFQVKLGTIYDKTLRLEKLSADILDSLGLVDEKADTIRAAKLS
                     KADLVTGMVGEFDELQGFMGKEYAKVGGENDVVSEAIFEHYLPRFAGDILPKTNAGVA
                     LSIADKLDSIAGFFAIGIQPTGSQDPYALRRQALGILSILMDRKVAVDIKILIEHALD
                     NYSELDFNKEEVVEQIMNFFNERVKNLFKDLGIRYDVVDAVLSSDINDVSDMHMRALE
                     LNNWLEKDELVEMLTAFNRVSTLAQKAESDKIDESLLKEDAEIKLYNEFKQVKVKVNE
                     LLKDKKYGIALDEFASLRPVVDNLFDTVMVMDNDEAIKNNRLALLKQVYDTMLGICDL
                     SKIVYK"
     gene            complement(26287..27834)
                     /locus_tag="KR257_001837"
     CDS             complement(26287..27834)
                     /locus_tag="KR257_001837"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454727.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nitrite/sulfite reductase"
                     /protein_id="HBH0030541.1"
                     /translation="MDNFKKILLNELPNFKEYSSKFLNGEINKMQYKGFSGGYGVYAQ
                     RDKKSFMIRLRVSAGVLSQYQLNKIYEIAIKHNLDKIHLTTRQAIQLHDLSINSIVDI
                     MEEGIKNDIFTRGGGGNYPRNVGLSPLSGVDPSEVFDVTPYAVATDKYFIKNATTYHL
                     PRKLKVSYSNCYTDTAHCSIQDLGFVATLKNDEPYFRVFLGGGLGKQPKVALELDELI
                     KPKDALYCVEGMIKFFMDYGNYENKNRARVRYMVESLGEELFLEKFKEYYKLEKENGS
                     LELNIEEIDYSKPGVKIDIQDSRLIPQKQDGLYTVYIHPVGGILLTKDLSTLLKELDN
                     VENPMIRLGMTEGLYILNLNGNEAKRILEISKTISCNSQLEQSISCIGVPICQMGIQN
                     SQKMLHEIIDYFRLQNNEEILNKAPKLYISGCLNSCGVHQVGSIGLCGKKKNVDGIST
                     DAFELFVGGSFEIGKTRLGKSLGDFKASDIPEMLYKISDASSGNFYEWVNSNDNILNK
                     ITDKYKI"
     gene            28114..28881
                     /locus_tag="KR257_001838"
     CDS             28114..28881
                     /locus_tag="KR257_001838"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416661.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IclR family transcriptional regulator"
                     /protein_id="HBH0030542.1"
                     /translation="MGEIINALDRALDIILLLYHEKREMGITEISKAMGVYKSTVHRT
                     LVTLENKGFVIQNAENGKYWLGINLYAIGMVVGEKMSLTEIVKPYTKKLNQEFNEVVN
                     VSILEERAQDSPRSIIIHKEYGSNQLLSVNPSVGSSSECYCSAVGKCLMAFNDSIDFE
                     KYRKTPIHKYTEHTIDNWDDMMLFLAKIKEQGYAIDDEELEHGLTCIGAPILDKNNKA
                     IAAISLSGPTIRMREGDFEYKIKRVIETAKSISELFR"
     gene            29164..29361
                     /locus_tag="KR257_001839"
     CDS             29164..29361
                     /locus_tag="KR257_001839"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416663.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="4Fe-4S binding protein"
                     /protein_id="HBH0030543.1"
                     /translation="MEKVKLSVERCKGCYLCIEACKKDAISLSDYTNKKGFVTIKVDE
                     EKCIQCGACYTMCPDLVFEIL"
     gene            29390..30466
                     /gene="vorB"
                     /locus_tag="KR257_001840"
     CDS             29390..30466
                     /gene="vorB"
                     /locus_tag="KR257_001840"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890635.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="3-methyl-2-oxobutanoate dehydrogenase subunit
                     VorB"
                     /protein_id="HBH0030544.1"
                     /translation="MQSLLIKGNEALAEGAIRGGCRFYAGYPITPQSEILEMMAWRQK
                     EVGGVFIQGESEIASVNMVMGASALGARAMTSSSGPGFSLKQEGIAYWVSAGLPAVVA
                     CVQRYGIGDGFIGAGQDNYWQAVKGGGNGDYHLIVLAPNSVQENMDMAYESFELAEKY
                     MHPVLILSDATIGQMVEPCIAPPMKEYDMDKAPWAAKGTPVGEKNKVITDITYFEDQD
                     TWQKGYIEKMRKVQEDEQRWEEIEIEDAEVVFVAYGISSRIAEGAVRDARAKGMKLGL
                     IRPKTLWPYPRKAFKKLSDSLKGLVTVEMNMMAQMKEDVIIACDNRFPVYSVATAQYM
                     AEVNQLIDFAQQIIDGKAKQEEVF"
     gene            30469..31188
                     /locus_tag="KR257_001841"
     CDS             30469..31188
                     /locus_tag="KR257_001841"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454726.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="2-oxoglutarate oxidoreductase"
                     /protein_id="HBH0030545.1"
                     /translation="MAKKAPAIMMCENMFCGGCGHSIVDRIIGEVLTEMDICQDTIIC
                     SDIGCNHMFQFSMNVDVVVPPHGKMGAAMAAMKRVRPDKYIFTIAGDGGAYAIGLGET
                     MSAATRNDNVIFLVMNNNMFAMTGGQMAPTTIEGQYTASTPAGRNYADHGSTFDVVKV
                     MGNLDIAYLARGTITNPKEINTTKRYIKKALEKQKEKKGFCLIEVLVPCPTNWGLKPV
                     DAMKRIENELVPKYPLGEFID"
     gene            31201..31740
                     /locus_tag="KR257_001842"
     CDS             31201..31740
                     /locus_tag="KR257_001842"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416670.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="2-oxoacid:acceptor oxidoreductase family
                     protein"
                     /protein_id="HBH0030546.1"
                     /translation="MLNEIICAGFGGQGVLTAGKIIMYVAYKAEKKITWFPSYGNEMR
                     GGSANCNVVVSDEKIANPCVKNPDILLGMNSVSVDKYESLMKKNGYMFVNESLVSKDR
                     KYREDINVIKVPVTEIAQNLGNEKAANICMLGAMVKSLDLFTKEEFESGMCEYFENQG
                     KGKFNSKNVEAFEAGYDYE"
     gene            31897..32955
                     /gene="buk"
                     /locus_tag="KR257_001843"
     CDS             31897..32955
                     /gene="buk"
                     /locus_tag="KR257_001843"
                     /EC_number="2.7.2.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430878.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="butyrate kinase"
                     /protein_id="HBH0030547.1"
                     /translation="MKVLVINPGGTSTKISVFQDENEILKKNITHTREDLKNFSKVFD
                     EYDYRKQLIVDILSSENHSINSFDAVVGRGGLMKAIKGGTYTVSEEMIEDMRNEINGE
                     HASNLGALLAKTIADEIGVQSFVVDPVSVDEFDDVSRITGISDIEKASWLHALNHKAV
                     SRKIAQKLGGKYEDYNFIVAHLGSGISIVAHKQGKMIDGSGGRSDGPFSPERSGGLLA
                     YPLIELCYSGKYTHDEMVAKVSSIGGMYDYLGTKDMIEIENRIKEGDEKAKLIMDAFI
                     YQVAKEISMYGASLSGNVDRVILTGGISHSEMVVKGVAEKVSYLAPIEIVPGEMEMEA
                     LALGALRVLNGEEIAKTY"
     gene            32973..33866
                     /locus_tag="KR257_001844"
     CDS             32973..33866
                     /locus_tag="KR257_001844"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454723.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional enoyl-CoA hydratase/phosphate
                     acetyltransferase"
                     /protein_id="HBH0030548.1"
                     /translation="MLKDFNNLLEEAKKLEPVIVSVAVAEDKEVLKAVKSATDLNIIK
                     PILVGDKDKIESISREIGLKGHEIIGCQNPDESVKKAVEIVKNKEAKVLMKGLVNTSV
                     YMRAILNKETGLRTGRLLSLLAVYELPQYHKLLYCTDSGINVSPNLNQKKDIMTNALL
                     TMKSIGMENPKTAILTANEMVDPKIQSTVDANLLVEMEKSGEIPKCIVEGPIAFDVAF
                     DAHAAEHKGIKSNIAGDVDLLVFPNIEAGNILGKSWLRFNKAKWAGIVLGATNPIILG
                     SRSDTAEIKINSIALACLASQ"
     gene            33896..35104
                     /locus_tag="KR257_001845"
     CDS             33896..35104
                     /locus_tag="KR257_001845"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890629.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PLP-dependent aminotransferase family protein"
                     /protein_id="HBH0030549.1"
                     /translation="MKYAKRMDMVKASAIRDSQKKIAQKVASGGTVISFAAGLPDPNL
                     FPIEEISEITQKVLNERGKFALAYGPTKGEDELLDLLVKRMKEEENIDTKAENIIITT
                     GSQQGIALSAMILLEKGDVVVTENPSYLGAINAFRPYECDFLGVDTDEEGMVTDDLDK
                     LLSENSNIKVIYVIPTFQNPTGKTWSLQRRKDFMEVVNKYDVIVIEDNPYGEIRFTPE
                     PLPTLKSLDTKDKVLYLGSFSKVLCPGFRVAWMCGNVDIIDKAELLKQGIDLQSNQFS
                     QVQVIEFLKKYNLNEHIEKIRAEYKKRCLLMLDAMKKHFPEEAKYTEPDGGMFIWVEL
                     PESINVDDLLDKAIDAGVAYVSGESFFANNGPKNTMRLNYTTMSEEQIVKGVEILAEV
                     IKKELNYACE"
     gene            35128..36387
                     /locus_tag="KR257_001846"
     CDS             35128..36387
                     /locus_tag="KR257_001846"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454721.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MFS transporter"
                     /protein_id="HBH0030550.1"
                     /translation="MGEKENGIKFGKLMFQLVIIAISWELVYIIPFIQYTLYDPILKA
                     LECTNTQLGFLLTIYGLGNIFGAPIGGWLADRFDYRKIILGSVFLNGVVSFLFAFNMN
                     YPFAVATWVGCAITSLVMNYPSMVKILRVIGKDNQGKVYGFNEAMVGVSGVVMGAIFL
                     YIYTCFATPTLGMRWVMISLGILSIAMCPVLWFVIKDVDIKEEREEAGEKMSAGDFIT
                     VLKSPNTWLVGISIFCVYSFTVTMSYFTPYITSVLGGSVALSGALAIIRQHGLKLFGA
                     PFGGYCADKLKSPTKVLLPIYVFGIAVIVLFLVLPASTPMTIFIALTFVVGILGYMGK
                     GIYYAVQDEVKVPVKYSATTIGIAAALGFSPDVFQFALIGHWIDTYGNKGYTYTFIFQ
                     IAILVIGILSCLYILKVKKRRASKLEA"
     gene            37032..38495
                     /locus_tag="KR257_001847"
     CDS             37032..38495
                     /locus_tag="KR257_001847"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018112852.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alanine:cation symporter family protein"
                     /protein_id="HBH0030551.1"
                     /translation="MTDLVNTINGIVWSPVLVAMCLCIGLYFSLKLKFFQIRDVKEMF
                     TLLLEGDSSHVGISSFQGFATSMAGRIGTGNIAGVAVAIAMGGPGALVWMCIMATLGS
                     ATAFVESTLAQIYKDEHDGQYRGGPPYYFEKGLGWKKCSVLFSIVAIISYTFFMPGTQ
                     SNTLYLAMNQAFGFSKMTIAVASSIALAIIIFGGIKRIGLFAEKVVPIMGGAYLIMTL
                     VIIITNISLVPEAIVTMFKSAFGFGSVFGGMLGSAISWGVKRGIYSNEAGEGSGTYGA
                     AAAEVSHPAKQGLVQAFSVYVDTLLICMATGIMIVITGMYNVTGVCTALPGVEPGPQY
                     VQSAINTLHPQLGDIFIAIVLLLFTFTTLLAFSYMMETNVSYLVTRIKAEKHEKYIIN
                     VCRFMLIACAAMCCFIEPLTSWALGDICIGVLTYINLIAIFTLKKPAIKAYYDYIRQK
                     KMGIKRSDRTFNPIELDIRNAEFWENRYLKEDKHELN"
     gene            38551..39687
                     /locus_tag="KR257_001848"
     CDS             38551..39687
                     /locus_tag="KR257_001848"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009905908.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="M20 family metallopeptidase"
                     /protein_id="HBH0030552.1"
                     /translation="MKERIIQVADSKKEKILGLCQSLYDEPEIALQEYKSAKKISEFL
                     REEGFDVEENLAGMATAFKATKKNGDGPKIAFIAEYDALPGNGHACGHHLIASMGVGA
                     GIALSSILDTYKGEVSIIGTPAEETGDGKPYLIEHGVFDGYDAAMMIHPNSKTCVTPE
                     IIAIGGLDFIFTGKASHAGAKPYNGINALDAVVLLYNNINALRQQLVDGTRIHGIILE
                     AGTAANVIPDMGKVRLEIRAKEQNYFDEVVEKVKNCARGAAIATGCELEFYHFEPTCQ
                     GLNENKVLVDIFTKIMEEFGIYEDEQVMLGSTDMGNLSQIMPCIHPLMKFSENGEELH
                     TKEFLEASINSYAKDRVIDGIKILALTGFNLFENPELLKKMKEE"
     gene            39923..>40899
                     /locus_tag="KR257_001849"
     CDS             39923..>40899
                     /locus_tag="KR257_001849"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728789.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="linear amide C-N hydrolase"
                     /protein_id="HBH0030553.1"
                     /translation="METLEVRNIELSGTNYEIGYRLGELVANMPEIIEGQINKSNLVS
                     KKEEKEMIELFDKYCPGLNEELQGFADAIQVNCNQILYYTMTYLKPGCSQVALAPELT
                     ENGHVLFARNFDFSHNMEDFVLCKTKVNGKYAHIGTTVMQFGRGEGMNECGLGVSQSS
                     CGIPVGNSDGLRKPAIVGLQFWAVIRYLLENCKDVDEALEYLKDMPIAYNINLLLADK
                     SGNIALVETLDGKKEVNIINSLESKREYFLHSTNHTHIDKLHKLEPQSMKNSIHRYKL
                     IKEYINKSKKIGEKELMNLLSSKYPNGLSCNYYNDFFGTLKSIVMDLNIG"
BASE COUNT        16280 a         4215 c         7472 g        12932 t
ORIGIN      
        1 aactaaatgg ctactagcat ctaacttttg gttttcatat ggatagatat ttattttttt
       61 attaagctgt ctttctaaaa aatcttttaa ctcttccata aagtctcctt aaaaataaga
      121 ttatattctt atcttatagc taaagtagtt tctttgtcaa atatgtgtac tctactattg
      181 tcaactgaaa gtgttaagtc atcaccaaca ttaattctgt ttttactgtc aaatctaatt
      241 gttatcgtat tttcgcctag ttttaagtga gcataagttt ctgctcccat aagttctttt
      301 atttcaattc ttgatttaaa acaagtatct ggattagatt taataaaagt atcttctaca
      361 tgaatatctt ctggtctgat acctataaca acttcattat taatataatt gtcttttatt
      421 aaatcatagt gtttttcttt attcaattta agcttaatat gttcattttg tgcataaatt
      481 tcatcatttt cttctattaa tattacatca ataaaattca tctgtggtgc tccaataaat
      541 cctgcaacaa atatattagc tggataatcg tatacatctt gtggagttgc aatctgctga
      601 actactccat ccttcattac tacgattcta tcagccatag tcatagcttc aacttggtcg
      661 tgtgttacat agataaatgt agttccaagc tgttggtgta gcttagttat ctctgttctc
      721 atagcagttc taagttttgc atctaagttg gatagaggtt catccattaa gaatacctta
      781 ggatttctaa ctattgcacg tcctaaggca accctttgtc tttgtcctcc agataatgtt
      841 ttaggttttt tatttaaaag aggtagtaag tctaatattt tagcagcttc tttaactttt
      901 ttgtctattt catctttagg caattttcta agtttaagtg caaatgccat gttttcgtaa
      961 acagataagt ggggatataa agcatagttt tgaaaaacca tagctatatc tctatctttt
     1021 ggttctatat cattgacaag tttatctcca atgtatagtt ctccttcaga gatttcttca
     1081 agaccagcaa tcattctaag tgtagtcgat ttaccacaac cagatggtcc tactaaaacg
     1141 ataaattctt tatctttaat gtctatattt atatttttta ctgcattaaa tccatttgag
     1201 taaagttttg atatattttt taaaattact tctgacataa tatcctcctt gatatttaaa
     1261 ttttaattat atagtatcaa atttttttat tatattaaat gtgtaaaatg actaaatgta
     1321 tttgtttaat atgtatagtt agtttttata ttaagattta ttataattta gaaaatatat
     1381 tttaattttt ttaattttta tgtataataa tatatatatt ttttagatta acaatatggg
     1441 atttaaatta ttttttaatt tataatgaaa taatattata ttagtagttt tggttaacaa
     1501 tgaggagttt ataaataagg tcatataagt taaattatat cgattttatt taaataaccc
     1561 catatttatt aattattaga aatatatttt aattattgac taaataataa atactgtaat
     1621 ataatggaaa tacagtttaa taaatataaa aagagaaaga gggaatttta aatgaatttg
     1681 aagaaaaaag agaaaatagt taagcctgtt ttaaagaagc ttacagaaat agtattaaat
     1741 atattatcaa aaaaaatatt aaactatgct atatatgcaa tttctgtttt gatagtaaca
     1801 aaagttgtta taaatataga tttgtacata tccatattgt attattagat atcttataga
     1861 tataaaaaat taatagatat atatctatta attttttata ttacaaatag agaataatga
     1921 attatactag aaagtaggag gtgaaaatat gagcagaatt tcaattttta tggaatcatg
     1981 taatggcaaa tttccaaatg aaaattcaat gttgtcagtt tcctttataa aaaatatttt
     2041 aaatgcagaa aacaaagatt ttgctaaaaa catatttaac tatggggaag aaagaaaaaa
     2101 caataagcaa ataaaggata taaatacagc catttacata ccaaatctta taagaagcaa
     2161 aaatgagtta cttgttgatg gagatataat attcaatata agtttttata attattctat
     2221 gttcagtaaa ttatacaatg gaattttaaa agtaaaggag ctagaatata aaggttatag
     2281 atttaaaata aaaaatataa aaatacataa agaacacgag ataaaagaaa atggtgttat
     2341 atttaaaact atgtctccta taatagtaaa gaataaagaa ggtaaatatt tagatgtaga
     2401 agattcaaat tatatagaat gtttaaacta tatagctaat ctaactctgg agagtataag
     2461 aggtagtggg cttagaaagc cattggaatt tatacctctt aacttcaaaa aaagagtgtt
     2521 aaaagaaaag attcgtggat ttaaagagag agaattttac tatataaatg cttatgcagg
     2581 aacatttttt ttaaaaggaa atatggaaga tttaaatgca ctgtataaaa tgggaattgg
     2641 atatagaagg acggaaaatg caggaatggt tgatatatta aagtagcgag gtgagagaaa
     2701 taaaagctaa attttataga tcaggtgata ttgtaagaga tattggcatt gtttactttt
     2761 gtgaattact aatggattta aaaaacgaac tagaaaaaaa tgattataag ctaaaattta
     2821 cttgtgagtt gaatagaaat tatttatctt tagaatctgc agaatatata gaccctaagt
     2881 atatatctga ttatatatta gaaaatcaac tttttaaggt atttaaaaat gggaaaaagg
     2941 aaaccttaga aaaaatattt agtaatatag ataatttaac atatgtaaat tttattgaag
     3001 aattggataa atcttctgca actgagaaac aaaaggaagg gattaaaaaa gattttaaaa
     3061 acagaagatt tccatatgtt agaaatagtg gtaagtatgg attaaacacg agtctagaaa
     3121 atatggaaaa aaatgtaaaa agaatagtcg atattgtgat taaatcaaat atagagatag
     3181 atgaaataga taaacttgat ttgaaacaat atgaagaaaa agatagtgta tgtaatgttt
     3241 gcaatataaa taaaacaaca aaactagata ttgatttaag agaacgaaag gactctaagt
     3301 ataacttttt atttagaggt gcagaaaaat caggttttaa aagaagtgga caagttgaaa
     3361 gtaatatttg ttttgagtgt gaatttttca acttaatgtg tcttttatat ataaatttaa
     3421 aaagaccaat ggtttttgca tatacgaatg atttaagaga attagcattt ttaaatcata
     3481 agataatgct taaaagaaaa atgtattcag ataaatcatt ttataaaaaa cttttgcatg
     3541 aaaaaataag ttcaattaga ctatatagga ttgatattga tacgaataaa ggtataattc
     3601 taaaatttga ctctattata gagtataaag aattattaaa aaaaattgaa cttatagata
     3661 ttatagataa ttataatttt tcaagagagc caatgaatac tagaaatttg ggtaaaaaaa
     3721 tgattaataa tgggaattta tcaaatttaa aagaattatt acttgataat ataagtgttt
     3781 taaggcaact aactggaact tctcgagaaa tggattttgt atctagttca tataatatcg
     3841 gtttatatat aaaattgtgt tggattgtag atggaaggga ggagtataaa atgaaaaact
     3901 atatagaaag taatttaata tattcaagag taggtaaaga cttatttaat aaaatgacag
     3961 atgaatccag aagaaaaaat ttttctatga aagtgattca actacttaag tctaatgata
     4021 gaactcagct atttcaaact ataatgcatg tgttagtttc taatggaatc ttaataggag
     4081 aagggtttgt agaaggtcta atgcagagtt ctgaattaga attaaatacg aatgtaggtc
     4141 tatttattca agaaatcatg aaataaaaaa gggggaaaat ttaaaatgaa tgaaaaaaga
     4201 gtaaaaggag taacattaac tatactgaca gaaagcccag ttccactttc gtatgaccaa
     4261 gggtatggaa attatacacc aataaaaaaa gaacaatata gagataaagt acatgcaaaa
     4321 actagtatag ctacaataac atatgattta agaagaatac tccatcaaga atatggttgg
     4381 aatttaagta atattgtttt tggaaaaaaa ggaaatatat atccatctat taagaaaaat
     4441 gtaggatgtg tagatgaaaa tggattagag actgatgtat ttggttattt aataccactt
     4501 aaagagaaag gttctataag taaggcttct ccgcttagaa taataccttt taggtcacta
     4561 aattcatata gaggttcaac acagttgata acaaatagag gttttttaag tagcgaattt
     4621 ggtagaaaat attatgatga gagggaagaa aatgaagtac ttagagatga aaactttcca
     4681 acaacacaag cattagcaat agaagagact ttatcagatt actacgttta tacaataaca
     4741 ttggagcttg atagaatagg agtagtagaa gtagaagaag atggaaagtt acttttacca
     4801 gaagaaagaa aatttatgag taaggagtta agagaaaaag cagtaaaaga tatattagat
     4861 gcaattactg tgtttacaag aaacataaaa cattcatcag tactattaaa accacttgca
     4921 gtaatgggtg gagcttttga taaagttgta ccattttttt gggatgatgt agattataat
     4981 gctgatagtg gtgagataaa tttagaggga gtcatagaaa ctatagaaag ttatagcctt
     5041 aaagaaagta acacaatact tgctatcaat gacagattaa aaatttctaa taaaaaggaa
     5101 ttaaataagt ttaatttaag taaataccct gtaaaagaga ttaaaaatct agcagataga
     5161 ttggaaattg gagaagataa tatgtggtat ttaaaagagt aggaggtttt ttgaattatg
     5221 aaagtattac aatgtaaact taagcaacca actgctcact atagagaccc aaaagtattt
     5281 caaaatgaat atataagtac tttaaattta ccatctaaga ccacaataat gggaatgata
     5341 acgtatttat gtgatagaag attaaactct gatatagata taggaataat tggaacacat
     5401 catcatagag aactagaatt ttcaagagga gagaacattg atttttggaa tgaatataca
     5461 aatatgagaa aaggcaaaga taaagaaaag tttttgcttc aaggaaacta ctatgattac
     5521 tataaagaac ataaagctca aaatagcata ttaaactatg aagttcttaa agaagtagaa
     5581 ctgactatat ttatttcttg caaggatgat gaagaacttg aatttattag aaaaaagctt
     5641 gaaagtccat gtaaatatgc aaatttagga agaaaagaag attttgtaat accaagtgaa
     5701 aaagggtgtt ttgtgaaaga agttgagtta aaagaggtta tacctatgaa tactcgtgat
     5761 gctataaaag aaaatataaa attaaagaat acatatgtaa gagttgactt aagagataaa
     5821 gagaatgtcg agactataat aaatcaaggt gtattgattg cattacctta taaatataaa
     5881 gatttagaag caaatagaga tgatagagtt tatgagtttt gccattatat atatgttgat
     5941 aatgatggta tatatcctaa aaatattaag gtaaatgtat gtattgatac aaaagaagtt
     6001 tttacatggc tttaaattat tttgaaagat aggtgtttat catgaaaaat atcatgcaaa
     6061 aagaaatatt agctaagtca tataatttaa gaactaatca acaagagcaa acattagttg
     6121 aacatattaa ggatttattt gaagtattag aatctatatt agaactaaat ctatattcag
     6181 ataaagatgt agagatacta aaaatatgtt gtgctttgca cgatttagga aaaattaatt
     6241 caattatgca acaaaaaatg gagattaata ataaaatatc gtatagttgc tcagaagaag
     6301 agaggaaaaa gttagagtct gacaaaaaat ctttaaaaaa gatagcaaga cataatatat
     6361 tttctggagc atttttaaaa gatatattag aaaaaatgaa cttgtcagaa gaagataagt
     6421 tatatatata taaaagtata atgttacatc atggaaacta tgaagattat atgaggttaa
     6481 gtattagtaa agttcaagaa gaaatttatg agtatattga aaaaggcatt ttagaaaaag
     6541 aagagtttaa tctgaaagat atagaaagtt atataaatag cattttaaat gtagacttta
     6601 aatttggtga agatgtattg gattatgatt acatagataa attaagtgaa agtatgttta
     6661 tagacagtga ttataacaat ggtcaaatag atgattcagt tttaaattat agaaagttta
     6721 agtatatttt atataaaggg atgctgaact taatagacca tagtgcatca agtagacaga
     6781 aaggtataaa attttataac gattttactg atgaagaaat tgataatatg attttaaatg
     6841 agatatataa gagtcagggt aatttggaaa aaaataatat agagttcaat actatacaaa
     6901 aaaggttgag agaactttct ggaagaaatg ttctgactgt tgcatttaca ggttcaggaa
     6961 aaacagctgc agattataga aagactttta aaagaaaatt ctttttagtg ccaaataaaa
     7021 tatcagcaga aagtttttat agaaaaaata tttttcaaaa taaaaatgat ttagatacaa
     7081 gaagtagtaa tgattacatt ggattacttc atggagatat aaacttatat tcagagaatg
     7141 aagataatgg agaacatgat tttgtattga cattaaggga tatagatttg agtataaact
     7201 tttgtaaacc ttgtgtaatt gcaacagttg accagttatt acttagtatg tttaaatttc
     7261 cgggatatga aaaaatattc gcagccgtaa aaaatgcatc tataactgtt gatgaagtac
     7321 atttattgga accaaagatg tttttgattt tgatatattt tatgcagttt gcatgcaagt
     7381 acttagatgt tgattttcac ttaatgacag ctacacttcc aaaatcatat aaagagcaaa
     7441 tgataaacaa gggaattatt tttcaagaag aaagtaatga aaatgttact gataaaggag
     7501 aaatagtttt tattgagagc aacaaggaag aagagatttg tgaaggtaaa gatgtaaagg
     7561 tttcttttat aaaggaaaaa gaaatcaagt caatagttga agatgcttta gaaaataaac
     7621 aaaaaattct tataataaag aatactattg attcagtcaa tagaacatat gagtttttaa
     7681 aagaaaattt atctgataag tatggtggtg tagatataga tgttttacat agtagattta
     7741 agttcaaaga taaaaaagag aaatatagta aaatattaaa tggagagggt gatatttgga
     7801 tatcaactca atcagtagaa atatccttgg atttggattt caatataata ataagtgatt
     7861 tagcaactat ggatagcttg atacaaagaa tgggtagatg taatagaaat aataaatatg
     7921 aatatggaaa cttttatatt ctacctagtg aagataaaat ttatgataac aaacttaaga
     7981 acacaactaa aaacatctta aaggacatat taaaaactaa ctctattttt acaatgggaa
     8041 ttagaaaaac tattttggat gattactatg ataatagtgt agtcaaaaaa tattttgaag
     8101 agaattttat aagttgtgat aaagaaatta agaatattta tggtataaat aaagaaattt
     8161 ttgatggatt ggatttaatt tttaattttg aaccttacaa aaatattgtt gatagtaaga
     8221 aggaagcagc taaaattttt agagatgttg atgttagtta caaaattatt ctggaagaag
     8281 atttttataa ggaagataga gagttacaac aagattcgat tcaagtatca gggtttatat
     8341 ttaatagatt atattattat gggttaataa gcaaagtaga aggatacatg gtactaaaat
     8401 ctagtagtaa gtttgagtat aatagtactg taggcttaat tttgaagtga gcatatgttt
     8461 aaatataata tacctttaga cattgaaaat acaaaaagta ctactgtaag ctcactgtaa
     8521 aaactatttt tttaaaagga aaaataagtt gtgagataga gtgtttacaa gtgtatatag
     8581 ataataaatt tgaggtttaa gattaactaa gtgggtttca ggtacatcgc gaaaataatt
     8641 ataagttgga gattttgtat gtttaagatt aactaagtgg atttcaaata ttgatatagt
     8701 agatataata gaagttttat tattaggttt aaaattaact aatcggattt ttaaatattc
     8761 tgactattat ataaggatat tattagcttg aatttaaaac caataatata aaacaacaaa
     8821 atattatatt tatgatataa taaaagttat ggaaaaacag gaatattact atagagaaga
     8881 gaggtaaact tatgaataat tggatagaag taactataaa aacaacaaca gaagcagttg
     8941 aacctataac gaatatacta tatgaacaag gagctggagg agctgtaata gaagacccaa
     9001 aagacttttt attccaaaag aaaaatgaac tagactggga ttatgttgaa gaagaagtat
     9061 ttaaaaagaa tgaagaagat gatgttctta taaaaactta tgtttctgaa gaaaaaaatg
     9121 tgatggaatt tgtcgaaata ataaagcaaa aagttttagg gttaaaagat tttggtatag
     9181 atataggtga aggaagtgta tcattggacc aagtaaatga agctgattgg gcaaatgcat
     9241 ggaaagcata ctacaaacca acaaaagtag gacaaagggt agtagtaaag cctacatggg
     9301 aagattatgc tatgcaagag ggggatttaa tcatagagct tgaccctgga atggcatttg
     9361 gtacaggtac acatgagact actagtatgt gcattagaga attagaaaag tacgtgaata
     9421 aagattctaa agtatttgat attggctgtg gtagtggaat ccttgcaata gcagcagcta
     9481 aattaggagc aaaagaagtt gtagctgtag atttagatga agtggctgta aaagttgcaa
     9541 aagaaaatgt tcttgaaaat aaagttgaaa aaagtgtatc tgtaatgcat ggtaatttaa
     9601 ctgatgtaat aaaagataaa gcggatgtaa tagttgcaaa tataatagct gatataataa
     9661 agatacttgc aaaagatgtt caaaacttta tgaaagaaga tgctatattc atatcttcag
     9721 gtataatttt ggataaagta gaagaagtta aagaaagctt aattgaaaat ggatttgaaa
     9781 tagttgaagt tcaaaaatta ggtgaatggt cagcaatagt ttctaagctt aaaaaataag
     9841 ggatatggtg acgtataatg gatagatttt ttgttgaaaa aaataatata aatctacaag
     9901 ataaaacttg cactatagaa ggtgaagatg taaaacatat ttcaaaagtt ttaagatgca
     9961 aattaggtga gaaacttgaa atatgtgaca agaataataa tgagtatatt tgtgagataa
    10021 tgaatataga taagagtata gttaatttag aaattttaga aaaagttgat ataaatagag
    10081 aatcagaact taaagtaagg ctataccagg gacttccaaa agctccaaaa atggaaatga
    10141 tacttcaaaa attaactgaa gtgggtgtag aagaaataat attagttcaa actaagagaa
    10201 gtgttgttaa agttgatgac aaaaaagaag ataaaaaatt tgaacgttgg gaaagaataa
    10261 tttatgaagc agcaaagcaa agcaaaagag gtaagatacc aaaattaaga ggtgttttaa
    10321 gttttaaaga agctttagaa gatatgaaaa aaaataatgt aaatatttgc ccttatgaaa
    10381 atgaaagaac agtttcaata aaacatgcac taaaaaaatg tgattctaat atagatagtg
    10441 ttggaatttt tataggtcca gaaggtggat tttctgaaga agaaatagaa caaatacaaa
    10501 aaaataattg taatgttgta tcattggggc ctagaatatt aagaactgag acagcttctg
    10561 ttgtagcatc aacaatagct ttgtatgaac taagtgattt aggaggagaa aaataaattg
    10621 aaaaaagtag ctttttatac acttgggtgt aaagttaatc aatatgaaac agaagctatg
    10681 ctagaactat ttgagaaaga tggttatgaa caagtcaata gtgaagagta tgctgatgtt
    10741 tatgttataa atacatgtac agttactcat atgagtgata gaaaatctcg tcaatatata
    10801 agacgagtta aaaagaagaa tccagatgca ataatagccg ttgtaggatg ttattctcag
    10861 gtatctccag aagaaatttt ggatatagaa gaagtaaatt tagtcatggg cacaaatgat
    10921 agaagaaaga ttgttgaaga aattaaaaag ataaattcaa gtaagaaagt tagtacagtt
    10981 gatgacataa tgaaagttaa agcttttgaa gaaatagaaa tcagccaaac taatggaaag
    11041 actagagcat ttatgaaaat acaagatgga tgtgacagat tttgtactta ttgtatcatt
    11101 ccttatgccc gaggacgcgt tagaagtaga gatattgata gtatagtcga tgaagtgaaa
    11161 aaattggcta ataatggcta taaagaggtt gtattaacag gaatacatgt tgcctcttat
    11221 ggaaaagatt taaaggatag ggatattaaa cttcttgatg taataaaaca aataaaccag
    11281 atagaaaaaa tagaaagaat taggcttagt tctgttgaac caattttatt tacagatgaa
    11341 tttgtaaatg aagttttaaa gatggataaa gtttgtcctc attaccattt atcacttcaa
    11401 agtggatgtg atgaaactct aaaaagaatg aatagacgat acacaacttt agagtacaaa
    11461 actattgtag atagattgag aagtaaaatg ccagatgtgg caataactac agatgtaata
    11521 gtaggttttc ctggagagac aaatgaagag tttaaaaaaa cgtacgagtt tttaaaagaa
    11581 atagagcttt cacaaatgca tatttttaaa tattcaccaa gaaaaggaac tccagctgca
    11641 actatggaaa atcaagttga ccctcaaatg aaacacttta gaagtgaaca acttttaaat
    11701 ttaagtaaag taaattttaa taaatttgca actaaattta tcggccgtga gttggatgtt
    11761 ttatttgaac aaaatataga aggcaataaa tatgagggat taacttcaaa ttatataaga
    11821 gttgttgttg aaagtgacaa aaatatacaa ggtcagatat taaaagtgaa aataaatgat
    11881 gtaaaagatg aatatgtaga aggaattttg ctataacatg tagaaattat aatatttata
    11941 agataggagg tggaaagaat ggattgtatt ttttgtaaaa tagcgaacgg agaaatacct
    12001 tcaactaaag tttatgaaga tgatagagtc ttagctttta atgacttgaa cccagttgct
    12061 ccatatcata tattagttgt acctaaaaaa cattatgata gtttaattga tattcctgat
    12121 aaagagatgg acattgtgtc acatattcat gttgttatta ataaaatagc taaagagaaa
    12181 ggttttgacc aaactggatt cagagtcata aataattgtg gaagtgatgg agggcaagaa
    12241 gttaaacatt tgcactatca tattttagct ggtaaaaagc ttcctaatta cgaagcggga
    12301 caaaactaaa ctaaattatt gaaaaattga gttccttctt gataaaaata cttgataaaa
    12361 gtaaaaattt agtttataat aaacaaagtg ttaggttgta atgcatatta tgcaaaaaga
    12421 acatagttac agtcccagca taattgcgct attggaggga gggaaaaaga aatgtcagaa
    12481 gtaagagtta gagagaatga aacattagac agcgctttaa gaagattcaa gcgtcaatgt
    12541 gcaatgtctg gcatcatgtc agaagtgaga aaaagagagc actatgataa gccaagcgtt
    12601 aagcgtaaga aaaaagctga agcagcaaga agaaaaaacg ctaagaaata gtagtaaata
    12661 agaataaaga ggtgaagggg atgtccctta agcaaaagtt acaagaggat ttgaaatctt
    12721 cgatgaaaaa caaagataca gtgagaaaat ctgtagtaac tttaataaga gcttctataa
    12781 agcagtatga ggttgataat agggtcgagc ttgatgaaga tggaattatc gatgtaatag
    12841 caaaacaatt aaagcaacgt agagatgcat tagttgaatt tgaaaaagct ggaagagaag
    12901 acttaataaa agaaacagaa ggtgaaattg aagttttaaa agagtaccta cctcaacaat
    12961 taagcgaaga agagttagaa gaaattgtaa aatctactat atctgaagta ggggcaactt
    13021 ctatgaagga tatgggaaaa ataatgtcag ttatccaacc aaaagttaaa ggaagagctg
    13081 acggaaaact tataaataag ttggtaaaac aaaacttaca atagattgat atagcctaga
    13141 gagaaatctc taggcttttt atagtttttg ggaataacga gtcatatttg agcatatcta
    13201 taatcaaaga aaattttgaa agaaggggaa aaatttgatt atatcagtaa aagagattag
    13261 gaattttttg ataaacatat ttataccact aataataggt tacttaagta gcatcttaac
    13321 aatgattatc agtggaacag atatttcaac ctattattta caactcacaa agccaagctt
    13381 tgcaccacca gcttttatct ttcctatagt ttggactata ttgtacatat tgatgggtat
    13441 atcttcatac ctaatattaa gaaagggtta caacttacct aaagtaagag atgcaatttt
    13501 ttattatgga ttacaacttg tattaaactt tatttggagt atactatttt ttggatttgg
    13561 acttagattt acagctttga tagatataat aataatgatt ttggtttcta taataatgat
    13621 ttcgaagttt tctaaaatag ataagagatc tggatacata aatttgattt atttaatgtg
    13681 gcttgtttat gcaggatttt tgaactattt tatatggttt attaataaat agaatgtaaa
    13741 gattttgtaa attaccctgt acttttaata atatcataac aaacgaaaaa taaatagact
    13801 attaaaaata atcattttca tatacaataa tattaattta aatacaataa atttataaaa
    13861 attgtattta aagattaaca tattaaagta ttagaattgg aaaggcttga agggagaggt
    13921 ttttatgcaa ataatagtat ctgggagaca aatgaaatta actgacggaa taaaaggata
    13981 cgtagatgga aaattaagta ggttagaaaa ataccttgat cctgaatcag aagtgaaagt
    14041 aacagtaagt gcgaaaaagg atagacaaaa agtggaggtt acaataattc ctattaacgg
    14101 tcaaataata agagcagaag acgtagaaga tgacttatat gcagcaattg atattgtttg
    14161 tgacaaatta agtagacaag ttgtcaaata taaaactaaa gttaaagaca aagttcaaaa
    14221 taataagagc ataagatttg aaaatcttga ctttatagat aatagcagtg aatttgatga
    14281 ttatgattat gatgatgaag aagatgagaa tatagtaata gaaagaagaa agaaatttaa
    14341 tgtaaaacct atgagttctg aggaggcgat acttcaaatg gaactagtag gacacaattt
    14401 ctatatgttt agaaaccaag ataattttga aataaacata gtgtataagc gtaaagctgg
    14461 tggatatggt ttaatagaac aagattaata aaaattgtat acgtttagat tttatataag
    14521 aaaaaataaa aaggtaatca tgttgatttt ttatcaatat gattaccttt ttcttgttta
    14581 aataatatat tagatattag gtatttatta tataaaaatt ttaaaactaa tctgttacaa
    14641 catcaataaa gtgcataaat acctatttca agcataaaat taattaaggg ggtaatgctt
    14701 atgttagaaa tatccactga tttacaagta aatcaaccag ttattactgt tacaagtaat
    14761 acgtttatta gtatagaaaa ttatctatca atattagaat atgaagttga tttaataaga
    14821 ataaagacta aagttaaaac aattaaaata tctggggata aactttcact taagtatatt
    14881 actgatagtg agataggtat aaaagggatt atctacaatg ttgagtatgt tgattaggag
    14941 gagatacact tgataagttt tataagggga tactatgtta tagttgtgga aggagtagga
    15001 ctcgaacaat ttttaaatca tcttataaga aatgggataa gtgtttacaa tgtaactaga
    15061 ataaaaaata ctaaaatgga gtttcatata gatagacaag atataaaaga atttaagaat
    15121 gtttatagag gaagtaagtt tgatataaag gtaaagcaaa aaactggggt cccttttatt
    15181 atcaaaagag tttataagca caaaggtatg tggatttgtg ctcttgtttc tttattttta
    15241 ttgatgtcta catcacagtt tgtgacagat gtatatatac aatctcctga aggtataaaa
    15301 aaagaagctc ttagaaatga gctttataag gttggagtaa gaccaggagt ctataagaag
    15361 agtattgata gaaaagaagt tagagaccat atgatgtcaa aatttaatga tgtggcatat
    15421 ttatctatca atgtaaaagg aacaaatata tttgttactg ttacaaaaaa ggcagaatcc
    15481 ctaaaatcta cagaccaatc aaattattgt aatgtaattg ctttaaaaaa tggtataata
    15541 gaaaaggtaa tccctagaag tggtaaatca gttattaaat ctggagacat agtccaaaag
    15601 ggagatgtct tattaaatgg agctaatacc aagtcaatac cagaagtatg ggcaagtact
    15661 ttttatgagt ccacaaaaaa ggcaagttat gtagatactg taaataaaaa aactggagaa
    15721 aagaaaaata tatatacact aagtttttat gataaagagt ttacaatgag aaaaaatata
    15781 aaatataaag attatgttgt tgaaaataaa gaaaaaaaac tatcaatagg aaactatact
    15841 tttccaataa agataaaaac gagtactttt tatgaaacaa aaaaggttga agtaaaaagg
    15901 aataaagaag agttaaaaaa agaattatct gaaaaagctt taaaagagtt agaatacata
    15961 atcccagctt cggctagaat aatagatgta aaacataact ttaaggttaa taaaaatatg
    16021 ttagaatatt taataacagt tcaaactagt gaaaatattg ctaaaattta tcctcttagt
    16081 aagtcagaag cagaaaggtt tataaaggaa gaaagtaaac cagatgaagg tgaagaggaa
    16141 gttccttcca atccagaaaa aagaccatta aatgatataa gaaatgagtt tgatgaggat
    16201 aataaggata ataaagatca aaacaattct gatgaaaata atagtaatca aaatagtaat
    16261 aatagtcaaa ataataatag caataacaac taataaaatt aaacttaaaa tcttaggagg
    16321 actaattcaa ttgataatac aaaagaaatt tacaatagca gatggtaact ttgaaagaga
    16381 gttatttggc aactttgatg aaaatgtaaa attaatagag aagactttaa atatagatgt
    16441 aatacttaga gaaggcaata taattttaat tggagaagaa aaaaatgtag attctgcatt
    16501 aaaacttatg aatgaattac accaaactgt atcaaatggt aagcatttag ataagcagag
    16561 tatttcttat tcattatctc ttttgcttga aggaagtgaa caaaaaataa aagaacttga
    16621 ggggacaatc gtcataactc aaaggggaaa agctgttcaa cctaaaactt taggtcaaaa
    16681 agaatatata aaacttatag aaaataatga tataactttt ggtgttggac ctgctggaac
    16741 aggaaagact tatcttgcgg ttgctatggc agtaaaagct tttaaaagag atgaagttag
    16801 tagaattata cttacaagac cagctgtgga agcaggagag agtctaggtt ttttaccagg
    16861 agatttaaag gacaaagttg acccatattt aagaccacta tatgatgcct tatttgaaat
    16921 gttgggtgct gataaattta ataagtattt agaaagaggt actattgagg ttgcaccact
    16981 tgcatttatg agaggtagaa cacttgataa ttcatttata atattggatg aagctcaaaa
    17041 tactacttct gaacaaatga aaatgttttt aactagactt ggatttggct ctaaagctgt
    17101 agttacagga gatgtaactc aaacagattt accacaaaat aagaagagtg gtctaataca
    17161 agctacagag attcttaaag gtgttccagg tattgggtct ataatgctaa cagatagaga
    17221 tgttgtaaga catgagttgg tacaaagaat aataagagct tatgagaagc acgacaaaag
    17281 agaagaattt aaaaaagaag aacgtaaaaa agcgaaaatg caggaaaaga ctttcaaaag
    17341 aaagtaaaag tgtagtaata tagatatata gcattattaa tgaataaaaa gtaggtgtag
    17401 tgaatggatt tgatactaga tgatagacaa gataaattag aagtaagtga ggagttaatt
    17461 gaaaagataa aggatataat catagaatgt ttagattatg aaggatatga tgataattat
    17521 gaagtgagtc tttcttttgt agataataaa gagattcatg aattaaatag agaatataga
    17581 ggagttgata gagtgactga tgttttatca tttcctcttt taagtgatga ttttgaggat
    17641 gttgagttag aagaagaatc cctaggtgac atagtagtat ctcttgaaag agccttagaa
    17701 cagagtatag agtataacca tagctttgaa agagaagtat gttttttaat atgtcatagt
    17761 atgtttcatc ttttaggtta tgaccacgat acagatgaaa atacaaaaga aatgagagaa
    17821 aaagaagaac acatattaaa taagttaaac ataacaaggg agtagttttt atgaaaccag
    17881 aaaaaactcg tcaaggtata attaaagcat ttaatgcagc tatagaaggg atattgtata
    17941 catttaaatt tgaaagaaat atgaaaatac attatttagg ttcagttgct gttcttataa
    18001 taagtttgtt ttttaacttt tcaaaattag aaatgataat gttacttatg tccatatgct
    18061 tagttgtagt tgctgaaatg tttaatacag ctatagaaaa agctgttgat ttagtaactg
    18121 atgaatatca tgttcttgct aagatagcaa aagatgttgc agctggaggc gttctagtgg
    18181 cagcactaaa ttcagtagta gttggatata ttttgtttta tgataaattg acagatatat
    18241 ctggaatatt aatttataaa ataagagaat cagaattaca tataaccttg atatgtatat
    18301 tattggttct tatagctgtt gtagttgtaa aagcattgac ttctacaggt actcctctaa
    18361 aaggaggaat gccaagtggt catgctgcct tagcatttgc tatagcaact gcaattacac
    18421 ttatgactga aagagttgtt gcctctactc ttgcatatat aatggctgta ttagttgccc
    18481 aaagtagaat tgaaggaaaa atacatacct tttgggagac tattgctgga gctttgttag
    18541 gtgtgttgat agctatatta gtatttcagc ttggaatgtt ctataattaa aataaatgta
    18601 cataaaatat ttaaaataaa acaaatctgt gctaattaaa tttttatgat ataatgtaga
    18661 gtattaaata aaaataactt ttaattattg tatacaggag gagttgttgt ggataacata
    18721 gaattgttaa ggttggcaga agatgccaga caacattctt atgctcctta ctcaggtttt
    18781 agagtaggtg cagctctttt aactaagagt ggtaaagttt atactggatg taatatagaa
    18841 tgtgcatcat taggtggaac aaattgtgca gaaagaacag ctatttttaa agcaatatca
    18901 gagggtgata aggatatcta taaaatagct atagcaagtg ataactcaga aaataatgag
    18961 caaacatatc catgtggaat atgcaggcag gtaattatag agtttggttc tgatataaaa
    19021 ataataacgg gatatactaa aggagaggtg tttgagcata gtataaagga tttgttgcca
    19081 aactatttct ctggaaatga tttaaaataa atttaaaagt ataaataaat ttaagtaatt
    19141 aaaacaagaa gataaaaagt taggagacag ttaatgttca aatcaggttt tgtcagtata
    19201 gtgggtagac caaatgtagg aaaatctact ttaatgaata atgtagttgg agaaaaaata
    19261 gctataatga gtgataagcc tcaaactaca agaaatacaa tacaagcagt atatacagat
    19321 gaagaaatgc agatagtatt cttagataca ccaggtattc acaaaccaaa aaataaatta
    19381 ggtgaattta tggtaaaggc agcaacagaa gcttttaaaa atgtagattt aatattattt
    19441 gtagttgatg attctaaaaa aataggtcct ggagatagaa agataataga ggatttaaga
    19501 agtgttaaga caccaataat tttagttgta aacaaaatag accaactaga ccaaaaagat
    19561 gagctatttg atataatcaa aatgtatgat agagaaggca tttttaaaga aatagtacca
    19621 atatcagcat taaaaggaaa gaatacggat accttaataa aagttataca aaattattta
    19681 gaagaagggc caaagtattt tccagattat atgattacag accagccaga aagagtatta
    19741 atagcagaac ttataagaga aaaagttctt cactatctta atgatgaaat acctcatggt
    19801 gtagctgttg aaattgaaaa aatgaaagcg agaaatgata aggaaatagt agatgtatct
    19861 gctgtaatat actgtgaaag agattcacat aagggaataa taataggaaa aaatggtagg
    19921 aaactaaaag gaataggtaa gtcagcaaga caagatatag aattgctttt aggttcacaa
    19981 ataaatcttc aattatgggt taaagtcaaa gaaaattgga gaaatttaca aaattatata
    20041 aataattttg gatataatga taaataaagg tgggttatat ggataggaaa ctggatgctt
    20101 cccaagattt attatatgaa gtaaaatcat taattgataa taataaagta ttggagttaa
    20161 gagaattaat agaggaatat catataattg atatattcga tataatggaa aatttagagg
    20221 aagacatgaa aattcaatta tttgaagtac ttcctttaga tatggcatct tctatattag
    20281 aagaaggtag tgtagagttt tttattagta ttttatctaa actggatgta gaacactcga
    20341 aaaatatact tgaacttatg tctcttggag atatggcaga caagttgagt gaacttgaag
    20401 aagaagaaag agaacacata ataaatcttt tgaatcaaga gaatgccgat tatgtaaaag
    20461 agttactatt ctatgatgaa gattctgctg gtggaacaat gaccactgga tatatttcta
    20521 taaataaaga tatgacagct cttgaggcta tagaccatat gagagaagaa gctgaagaag
    20581 ctgaaactat ttattatata tatgtggttg atgatgaaga aaaactagtt ggagtattgt
    20641 cattaagaga attaataata gctagagacg caaatatagt agaagatttg atgagtgaaa
    20701 atataatctc tgtttatgta gatgaagata gagaagaagc agtaagatta gtatctaaat
    20761 acaatttaat agcaattcca gtagtagaca gacaagaaaa attaaaagga ataataacag
    20821 tagatgatat aattgatgta atggaagaag aagcaactga agatatgtat aaatttgcag
    20881 gaagttcaga acatgaaaga gaagttgctg aaaaagaaaa ccctacattg agagagcaaa
    20941 taatatcagc acttagagga cgattacctt ggttaattat taccttagtt ggagggttgt
    21001 tggcttcgtt aatactttct aacttagact atataatgaa tcctgtatat gctccattag
    21061 tattttttat acctgtagta attggtatgg gtggaaatat tggaactcaa tcatcatctg
    21121 ttacagtaat aacattatct aataaggatt taaattttag caatgtggtt agagaaggta
    21181 ttgtaggtat tattacaggt cttttgtgta gtataataac aggtattgta atttactttg
    21241 ttatgagaaa gttagacatt gtattaattg tttcaatatc attatttata aatatggttt
    21301 taggtgcaac aataggtgcg tttatgcctg ttttattaaa aaaaatggat gcagacccat
    21361 ctacagtttc atcaccaatt atatctacag ctcttgatat aactggtata gcagtttact
    21421 ttataataac aacggcatta ttgtcaaaaa ttgtttaata actttatgta tgatttatcc
    21481 tcttcttact aaaaatataa gtataaatgt aagaaggggg ttttttaaaa atgaacaata
    21541 tcagttggga agtttttaaa aaaacaggta gtatagatgc atatttatat ttctgtgatt
    21601 gcaaaaacat acatgaagaa attgaagaag taagggagaa aaaagaagac gatgataatc
    21661 ctgaacaccc aggggatagt acttaaagct ataaggtata aggaaagtga tataatactt
    21721 acactattta caagaaagct tggaaaagta tctgcaatag caaaaggagc taaaaaaaat
    21781 aagagctctt tgctttcatc atcacagtta ttttcttata gcaattttac cttaaaaaaa
    21841 caaggtaata tgtacaaggt tactcaaagt gaaataataa aaagttttta taatatatcc
    21901 tatgatatag aggcattttc ttatgctaca tatattacaa aattagttga aaattctata
    21961 cttgaaaatc agactaataa taggctattt atattacttg cgcagactct gtatttgtat
    22021 acacaggata atacagacaa taggtttata acagcagcat tcgagttaaa atttttagac
    22081 tatataggat ttaaacctat agtaaataaa tgcattaatt gtgaatgtaa aattttacaa
    22141 aattctgtgt ttaatatcta cgaaggtggt atactatgta gtaagtgtag taaacttttt
    22201 gataataata taaaattaga cttaacaact ataagtctta tggaatatgt attaagaaat
    22261 gatattttaa catgtagtaa agctaaagta tcaaaatata taacacatga acttgagaat
    22321 attctagaca agtatttgaa agtttatgtt gataatatta attttaaatc attacacgta
    22381 ttgcaaagtg taaaaaataa taagggagtg gataatgatg agtagtaata taactattga
    22441 aatggttgat tcagtctttg aaagagttcc aggagcaact tatgcagaag caaaagaagc
    22501 attagtaatg tgcaatggag atgtaattga ggcagtaata tatttagaaa ataaaaaaaa
    22561 tacttgtaat tgtaaagcaa aatctgctaa agaaactatg gaagaagtat ttggcaaaga
    22621 tggagaaaat ataaagtttc aattaaaaga gcttcttaga aaaagtagtg tagtgagaat
    22681 aatagttgaa aaagatggaa aaactatgat gaatattcct ttaacagttg gagttgttgg
    22741 attagctttt gtaccattag ctactttagt tggattatca gctgctgtta taagtaaata
    22801 tcgtataaaa gttcaaaatg aagaagatgg agaaattgta gatttaggtg aattgaatga
    22861 agaaaaactt cacgttttga agaatatgat aactaatgca gcaaaagatg tgaaggatgt
    22921 agtagttgac aaaaaagaag atgacaaaga tgtaactgct gaccttatga aagaagaatc
    22981 tgaaaagaat aaagaagacg aagacgaaaa taaatagata taaagtgact tttaaaaaat
    23041 gaagagaaga taattataag aattatcact aacattgaca aattttatag aatttgatat
    23101 tctaaaagtt gtagaagaac tattaaaata gcctttcgtg tagacgagag gctttattgt
    23161 tataggaggg atttttatga attttcaaga gatgatactg gcgttgcaaa aatactggtc
    23221 aaagcaaggt tgtatcatga tgcaacctta tgatattgaa aaaggtgcgg gaactatgaa
    23281 tcctaatact tttttaagat cattaggacc tgagccttgg caagtatgct atgtagagcc
    23341 ttcaagaaga ccagcagatg gaagatatgg tgaaaaccca aacagactat atcaacatca
    23401 tcaattccaa gttatactaa aaccttctcc agataatata caagaattat atttggaaag
    23461 tttgaaagag attggaattg acccaagtga gcatgacata agatttgttg aagataactg
    23521 ggaagctgct acagttggtg cttggggact tggatgggaa gtttggctag atggtatgga
    23581 aataactcaa tttacgtatt ttcaacaagt aggtaatatt gaatgtgagc ttgagacagg
    23641 agaaattaca tatggattag aaagattagc tatgtacatt caagaagttg atagtgttta
    23701 tgatttaaaa tggaatgata aaataactta tggtgaagta tttaataaag ctgagtatga
    23761 aaactcaatg tacgcatttg aattatgtga tgcagatatg ttgtttaatc tgtttgatat
    23821 atatgaaaaa gaagcattaa gacttatgga aaatggcctt gtaataccgt catatgacta
    23881 tgtgttaaaa tgctctcatg catttaatac attggatgca agaggtgcaa taggagttag
    23941 tcaaagagct tcatttatag gtagagttag aaatatggca aagactgttg cagaaacttt
    24001 tgtaaaacaa agagaagaaa tgggattccc tcttttaaag gacggtgaca aataatgaaa
    24061 aattatcttt tatttgaaat cggtgttgaa gaaatgccat caagatttgt aggcagtaca
    24121 ctagaacaat taaaaaacaa tcttagtaaa ttatttgatg aaaatagaat agcttttgat
    24181 aaaataaatg cttatgggac accaagaaga cttactttag tagtcgaagg attgagtgat
    24241 agacaaagtg atttagaaga ggaaataaag ggtcctgcta aaaaaattgc tgttgatgca
    24301 gaaaataatt taacaaaacc agcattagga tttataaaaa gcaaaggatt aagcgaatct
    24361 gacatatatt ttaaacaagt tggaaaagaa gaatatatat ttgcgactat aaagcaagat
    24421 ggaaaagaaa cttcagaagt actaaaagac atattaccag agactataaa atctgtagta
    24481 ttcccaaaag ctatgcgttg gggaggaaaa aatcttaaat ttgcaagacc tataagatgg
    24541 atagttgcat tgttaaatga taaagtatta gagtttgatt tagaaggaat aatatcttct
    24601 aatgtaacaa aaggtcatag atttttaggt gaaagtacaa tagaagttga ttctatagaa
    24661 gattattttg aaaaattaga aaaaaattat atagttttag accaaaacaa gagaaaagaa
    24721 atgataagaa aacaatgtat agaagtagca aattctttag gtggagaagt tgaatttgat
    24781 gaagatttac ttgaagaggt aacttattta gttgaatatc caactgcttt ttatggagaa
    24841 tttgatgtgg attatataaa actaccaaaa gaagttgtta taactcctat gaaacaacat
    24901 caaagatatt ttccagtact taaagaagga aaactgttac ctaactttat agctgttaga
    24961 aatggtgatt cttacagaat agacaatgtt aaagctggaa atgaaaaagt tttagaagca
    25021 agacttgcag atgctttatt tttctataga gaagatacta agagaaactt agaaagctac
    25081 atagaaaaat taaaaactgt tgtattccaa gtaaaattag gaactattta cgacaaaact
    25141 ttaagacttg aaaaattaag tgctgatata cttgatagtt taggtttagt agatgaaaag
    25201 gcagatacta taagggctgc taaattatct aaggcagatt tagttactgg aatggtagga
    25261 gaatttgatg aattacaagg ttttatggga aaagaatacg caaaagttgg aggagaaaat
    25321 gatgttgtaa gtgaagctat ttttgaacat tatcttccaa gatttgcagg agatatactt
    25381 cctaagacta atgcaggggt tgccttatca atagctgata agttggattc aatagcaggt
    25441 ttctttgcta taggaataca accaacaggt tctcaagacc catatgcttt aagaagacaa
    25501 gctttaggta tacttagtat acttatggac agaaaagttg ctgtggatat aaaaatactt
    25561 attgaacatg ctttagacaa ttattctgaa ttagatttta ataaagaaga agttgttgag
    25621 caaataatga atttcttcaa tgagagagta aaaaatctat ttaaagattt aggaataaga
    25681 tatgatgttg ttgatgctgt tttaagttct gatataaatg atgtttctga tatgcatatg
    25741 agagctttag agcttaataa ttggctagaa aaagatgaat tagtggagat gcttactgca
    25801 tttaatagag tttctactct agctcaaaaa gcagaaagtg ataaaattga tgaatcttta
    25861 ttaaaagaag atgctgaaat taaactttac aatgaattta aacaagtaaa ggtaaaagtt
    25921 aatgaattat taaaggataa gaaatatggt attgctttag atgaatttgc atctttaaga
    25981 ccagtagttg ataatttatt tgatacagtt atggtcatgg ataatgatga agctattaag
    26041 aacaatagac ttgctttact taaacaagta tatgatacta tgctaggaat ttgtgattta
    26101 tctaaaattg tttataaata aaatttaaac tatttataag aaataaggct gtctcaaaat
    26161 agagatagtc ttatttttca ttgttgagat gatgaaaata tatttgattt catagaaaaa
    26221 gagtgtctca taaactaaaa agttcatttt gagacaccca tgttttttgt aagtaaatat
    26281 aataaattat attttatact tatcagttat tttgtttaaa atattatcat ttgaatttac
    26341 ccattcataa aaattgcctg aagatgcgtc cgatatttta taaagcattt caggaatatc
    26401 actagcttta aaatctccaa gtgattttcc caatctagtc ttacctattt caaaactgcc
    26461 tccaacaaat aattcaaatg catctgtaga tataccatca acattcttct ttttaccaca
    26521 taaacctatg ctaccaactt gatgaacacc acatgaattt aaacatcctg atatatataa
    26581 cttaggtgct ttatttaaaa tttcttcatt attttgtaat ctaaaataat ctatgatttc
    26641 atgtaacatt ttctgactat tttgtatgcc catttgacaa attggaacac ctatgcaaga
    26701 tatactttgt tctaattgag aattacaact aatagtttta cttatttcta atattctttt
    26761 tgcttcattt ccatttaaat ttaaaatata taatccctct gtcattccta gtctaatcat
    26821 aggattttca acattatcta attctttaag taaagtactt aaatcctttg ttaacaaaat
    26881 acctccaact ggatgtatat atacagtgta taaaccatcc tgtttttgag gtattagtct
    26941 agaatcttgt atatctattt taactccagg tttagagtaa tctatttctt caatattgag
    27001 ttcaagacta ccattttctt tttctaattt atagtattct ttaaattttt ctaagaatag
    27061 ttcttcacca agtgattcga ccatatatct aaccctagct ctgtttttat tttcataatt
    27121 tccataatcc ataaagaatt taatcatacc ttcaacacaa tataaggcgt ctttcggctt
    27181 tataagttca tcaagttcta aagcaacttt gggttgttta cctagacctc cacctaagaa
    27241 aactctgaaa tatggttcat catttttcaa agtagcaaca aatcctaagt cttgtatact
    27301 acaatgagca gtatctgtgt aacaattaga ataagaaact tttaattttc taggtaaatg
    27361 gtatgtagta gcatttttga taaaatattt atcagtagca actgcatatg gagtaacatc
    27421 aaagacttca ctagggtcaa ctccagataa tggagataat ccgacatttc taggataatt
    27481 accaccacca cctctagtga atatatcatt ttttattcct tcttccatga tatcaacaat
    27541 tgaatttata gataaatcgt gtaattgtat agcttgtcta gttgttaagt gtatcttatc
    27601 taagttgtgt ttaatagcta tttcatagat tttattaagt tgatactgag ataaaactcc
    27661 agcagatact ctaagtctta tcataaaaga ttttttgtct ctttgagcat aaacaccata
    27721 tccaccagaa aatcccttat attgcatttt atttatttct ccatttaaaa attttgaaga
    27781 atattcttta aaattaggta gttcatttaa caatatcttt ttaaaattat ccattatttc
    27841 acctcattgt tagtcttgta taaaaatata tctattgtat aatagatata tatattatta
    27901 tctagtcagg ataaaaatat aacagaataa ttctattaaa agtaagaata ataaggacat
    27961 agtgagtatt ttgtttttat tttacaaatt aagtataata tttttgtttt ataaaatata
    28021 attaagataa atagataatt ttgtaatttt aatatataat atttagtaga gtgtgggagt
    28081 agcacttaat atttgcagga ggagtttttg tatatgggag aaataataaa tgcattagat
    28141 agagccctag acataatttt gctgttatat catgaaaaga gagaaatggg aataactgaa
    28201 ataagtaagg ctatgggagt atataaaagt actgtacata gaactttggt tactcttgaa
    28261 aacaaaggtt ttgttataca aaatgcagag aatggtaagt attggctagg aataaattta
    28321 tatgcaatag gtatggttgt gggagaaaaa atgtcattga ctgaaatagt aaaaccatat
    28381 acgaaaaaat taaatcaaga atttaacgaa gtagttaatg tatctatatt agaagaaaga
    28441 gctcaagatt ctccaagaag tatcataata cataaagagt atggttcaaa tcaattactt
    28501 tcagtaaatc catccgttgg ttcaagtagt gaatgttatt gttcagcagt tggtaaatgt
    28561 cttatggcat ttaatgattc tatagatttt gaaaaatata gaaaaacacc aatacacaag
    28621 tatacagaac atacaattga taattgggat gatatgatgc tttttttagc aaaaataaaa
    28681 gaacaaggat atgctataga tgatgaagaa ctagaacatg gactaacttg tattggagca
    28741 cctatcttag ataaaaataa taaagctatt gcagccataa gtttgtcagg tccaactata
    28801 agaatgagag aaggggactt tgagtataag attaaaagag ttatagaaac tgcaaaaagt
    28861 atatctgaac tttttagatg atttttaatc tcgataataa aaataggcta tatttaaatt
    28921 gttatttgta aatatcagtt taaatgtagc ctatttttct ttaatctaaa attaaatatt
    28981 cttaaaattt aaaatgttat tgaaatatat aagcgaatgt gttatctttt aattaagcaa
    29041 taaaaataga acaaggttct atactataga acaaaattga tgcatatata gtatttatac
    29101 aaaatataaa tattatatat ttaaaattaa gtaaaaatat tacataaagg ggagatttga
    29161 gaaatggaaa aagtcaagtt gagtgttgaa agatgtaagg gatgctatct ttgtattgaa
    29221 gcttgcaaaa aagatgcaat aagtctttct gactacacaa ataaaaaagg ctttgtaact
    29281 attaaagtcg atgaagaaaa atgtattcaa tgtggcgctt gttatacaat gtgccctgat
    29341 ttagtatttg agatattata aattattttt attagagggg agaaaaggta tgcaaagttt
    29401 attaattaaa ggaaatgaag ctttagcaga aggtgctata cgtggtggtt gcagatttta
    29461 tgcaggttat ccaataacgc cacaatcaga aatattagaa atgatggcat ggagacaaaa
    29521 agaagttgga ggagtattta tccaaggtga atcagaaata gccagtgtaa atatggttat
    29581 gggagcaagt gcacttggag caagagctat gacttcttca tctggtccag gattttcatt
    29641 aaaacaagaa ggtattgcat attgggtatc agctggtttg ccagcagttg tagcatgtgt
    29701 gcaaagatat ggtataggtg atggatttat aggagctggt caagataatt attggcaagc
    29761 agtaaaaggc ggtggaaatg gagattatca tttaatcgtg ttagcaccta atagtgttca
    29821 agaaaatatg gatatggcat atgaatcttt tgaattggct gaaaaatata tgcatccagt
    29881 acttatactt tctgatgcta caataggtca aatggtagaa ccttgtatag caccaccaat
    29941 gaaagaatac gatatggata aagctccatg ggctgcaaaa ggaacacctg taggagaaaa
    30001 aaataaagta ataactgata taacatattt tgaagaccaa gatacatggc aaaaagggta
    30061 tatagaaaaa atgagaaaag ttcaagaaga tgaacaaaga tgggaagaga tagaaataga
    30121 agatgctgaa gtggtatttg tggcatacgg tatttcatca agaatagcag aaggtgcagt
    30181 tagagatgct agagcaaaag gaatgaaatt aggtctaata agaccaaaaa cattgtggcc
    30241 ttacccaaga aaagcattta agaaattaag tgattcattg aagggacttg taacagttga
    30301 aatgaacatg atggcacaga tgaaggaaga tgtaattata gcatgtgata atagatttcc
    30361 agtatattca gtagcaacag ctcaatatat ggcagaagta aatcaattaa tagattttgc
    30421 tcaacagatt atagatggaa aagctaagca agaggaggta ttttaattat ggctaaaaaa
    30481 gcaccagcaa taatgatgtg tgaaaatatg ttctgtggag gctgtggaca ctctatagtc
    30541 gatagaatta ttggagaagt attaacagaa atggatatat gtcaagatac aattatatgt
    30601 tcagatatag gttgtaatca tatgtttcaa tttagtatga atgtagatgt tgtcgttcca
    30661 cctcatggta aaatgggagc agcaatggca gctatgaaaa gagttagacc agataaatat
    30721 atatttacaa tagctggaga tggtggagct tatgcaatag ggcttggaga aactatgtca
    30781 gctgctacta gaaatgataa tgtaatattt cttgttatga acaataatat gtttgcaatg
    30841 acaggagggc aaatggctcc aactactata gaaggtcaat atacagcttc tactccagcg
    30901 ggtagaaatt acgcagatca tggttcaaca tttgatgttg taaaagttat gggaaattta
    30961 gatatagcat atctagcaag aggaacaata actaacccta aagaaataaa tacaacaaaa
    31021 agatacatca aaaaagctct agaaaaacaa aaagaaaaga aaggtttttg cttaatagaa
    31081 gtgcttgtac catgtccaac aaactgggga ttaaagccag tagatgctat gaagagaatt
    31141 gaaaatgaac ttgttccaaa gtatccactt ggagaattta ttgattaggg aggaaataat
    31201 atgttgaatg aaattatatg tgctggtttt ggaggacagg gagttcttac agcaggaaaa
    31261 attataatgt atgttgcata taaggcagaa aagaaaatta catggttccc atcttatgga
    31321 aatgagatga ggggaggaag tgcaaattgc aatgttgttg taagtgatga aaaaattgca
    31381 aatccttgtg taaaaaatcc agatatacta ttgggaatga acagcgtatc agtagataag
    31441 tatgaaagtt taatgaaaaa aaatggttat atgtttgtca atgaatcact agtaagtaag
    31501 gatagaaagt acagagaaga cattaatgtt ataaaagtac ctgttactga aatagcacaa
    31561 aatttaggca atgaaaaagc tgctaacatt tgcatgttag gtgctatggt aaagagtttg
    31621 gatttattta caaaagaaga atttgaaagt ggtatgtgtg aatactttga aaatcaaggc
    31681 aaaggtaaat tcaattctaa aaatgtagaa gcatttgaag ctggatacga ctacgaatga
    31741 atattttaaa tatttaaaat aattattgaa atacttattt ttatatgtta gtatttaatt
    31801 aataaaatat agaacgtcgt tctgaacaat aggacgaagt ctttaggtcg gaatacaaga
    31861 acgacgttct gtatagtaga actagggggt gttaaattga aagttttagt aataaatcct
    31921 ggtggtacat ccacaaaaat ttctgttttc caagatgaaa atgaaatttt gaaaaaaaat
    31981 ataacccata caagagaaga tttaaaaaat ttttctaaag tatttgatga atatgattat
    32041 agaaaacaac tgatagtaga tattttaagt agtgagaatc atagtataaa ttcttttgac
    32101 gcagtagttg gtcgtggtgg acttatgaag gctataaaag gtggtaccta tactgtgagt
    32161 gaagaaatga ttgaggatat gagaaatgaa ataaatgggg aacatgcatc aaatttaggt
    32221 gcattattag ctaaaactat agctgatgaa ataggagtac aatcatttgt agtagaccca
    32281 gtttctgtag atgaatttga tgatgtatcg aggattacag gaatatcaga catagaaaaa
    32341 gcaagttggt tacatgcatt aaaccataaa gctgtttcaa gaaaaattgc acaaaaacta
    32401 gggggaaaat acgaggatta taactttatt gtagctcatt taggttcagg aatatcgatt
    32461 gtagcacata aacaaggcaa aatgattgat ggaagtggtg gtaggtctga tggtccattt
    32521 tctccagaaa ggagtggtgg attacttgca tatcctctta tagaattgtg ttactccgga
    32581 aaatatactc atgatgaaat ggtcgcaaaa gtaagttcga ttgggggaat gtacgattat
    32641 ttaggaacaa aggatatgat agaaattgaa aacagaatca aggagggtga tgaaaaggca
    32701 aaacttataa tggatgcatt tatttatcaa gtagcaaaag aaatttctat gtatggagct
    32761 tcactttcag ggaatgtaga tagagttatc ttgacaggag ggatatctca ctcagaaatg
    32821 gtagtcaaag gagtagcaga aaaagtttca tatctagctc caatagagat agtaccagga
    32881 gagatggaaa tggaggcact tgctctaggg gcacttagag tacttaatgg agaagaaata
    32941 gcaaaaactt attaatattt aggagaaaga gtatgttaaa agattttaat aatttattag
    33001 aagaggctaa aaagcttgaa cctgttattg taagtgttgc tgttgcagaa gacaaagaag
    33061 tattaaaggc tgtgaaatca gcaacagatt taaacattat aaagccaatt cttgtaggag
    33121 acaaggataa aatagaaagt atatcaagag aaattggatt aaaaggtcat gaaataatag
    33181 gttgtcaaaa tcccgatgaa tcagttaaaa aagctgtaga gatagttaaa aataaggaag
    33241 ctaaagttct tatgaaggga ttagtaaata caagtgtcta tatgagagct atattaaata
    33301 aagaaacggg tcttagaaca ggaagattat taagtttgct tgcagtatat gaattacctc
    33361 aatatcataa acttctttat tgtactgata gtggaataaa tgtatcgcca aacttaaatc
    33421 aaaaaaaaga tataatgaca aatgcacttc ttactatgaa aagtataggc atggaaaatc
    33481 ctaaaactgc gatacttact gcaaatgaaa tggtagaccc taagatacaa tctacagtgg
    33541 atgccaacct acttgtagag atggaaaaat cgggagaaat accaaagtgt atagtggaag
    33601 gtccaatagc atttgatgta gcatttgatg cacatgcagc agaacataaa ggtattaaaa
    33661 gtaatattgc tggtgatgtt gatttattag tatttccaaa tatagaagca gggaatatat
    33721 taggaaagtc atggcttaga tttaataaag ctaagtgggc aggtatagtt ttaggagcaa
    33781 caaatccgat aattttaggt tcacgttctg acacagctga aataaaaata aattcaatag
    33841 cattagcgtg cctagcatca caataagaaa ttattattaa ggaggaaaaa gtattatgaa
    33901 atatgcaaaa agaatggata tggtaaaagc ttcagctata agagattctc aaaagaaaat
    33961 agctcagaag gtagcaagtg gtggaactgt tatatctttt gctgcagggc ttcctgaccc
    34021 aaatttattt ccaatagaag agataagtga aataactcaa aaagtactta atgaaagggg
    34081 aaaatttgcc ctagcatatg gacctactaa aggtgaagat gagttgttag atctattagt
    34141 aaaaagaatg aaagaagaag aaaatattga tacaaaagca gaaaatatta taataactac
    34201 tgggtcacaa caagggatag cattaagtgc tatgatttta ttagaaaagg gagatgtagt
    34261 agttacagaa aatccaagtt acttaggtgc aataaatgca tttagacctt atgaatgtga
    34321 ttttttagga gtagatacag atgaagaagg aatggtaaca gatgatttag acaaattatt
    34381 atctgaaaat tctaacataa aggtgatata tgtaatacca acatttcaaa accctacagg
    34441 aaaaacatgg tctttacaaa gaagaaaaga ttttatggaa gtcgtgaata aatatgatgt
    34501 catagtaata gaggataatc cttatggaga aataagattt acaccagaac ctctacctac
    34561 acttaaatct cttgatacta aagataaagt attgtacctt gggtcatttt caaaggtatt
    34621 atgtccagga tttagagttg cttggatgtg tggtaatgta gacatcatag ataaggcaga
    34681 acttttaaaa caaggtatag atttacagtc aaatcaattt tcgcaagtac aagtaataga
    34741 atttttaaag aaatacaact taaatgaaca tatagaaaaa ataagagcag agtataagaa
    34801 aagatgtctg ctaatgttag atgctatgaa gaaacatttc ccagaggaag ctaaatatac
    34861 agaaccagat ggaggaatgt ttatatgggt tgaacttcct gaaagtataa atgtagatga
    34921 tttattagat aaagccattg atgctggagt tgcttatgtt tctggagagt ccttctttgc
    34981 aaataatggt ccaaaaaata ctatgagact taactataca acaatgtcag aagaacaaat
    35041 cgttaaaggt gttgagatac ttgcagaagt tataaaaaaa gaactcaatt atgcttgtga
    35101 ataaatataa aaagtgaggg tttaaatatg ggagaaaaag aaaacggtat aaagtttgga
    35161 aagttaatgt ttcaacttgt tattatagca atatcttggg aattagttta tattatacca
    35221 tttatccaat atacattata tgatccaatt ctaaaagcat tagaatgtac aaacactcaa
    35281 ctaggttttc tacttacaat ttatgggtta ggtaatatat ttggagctcc tataggaggc
    35341 tggttagcag atagatttga ttatagaaag ataattttag gttctgtatt tcttaatgga
    35401 gtagtatcat ttttatttgc atttaatatg aactatccat ttgcagttgc tacttgggta
    35461 ggttgtgcaa tcacatcatt agttatgaac tatccttcta tggtaaaaat acttagagtt
    35521 ataggaaaag ataatcaagg taaggtttat ggatttaatg aagctatggt tggagtttct
    35581 ggagtagtaa tgggagcaat attcttatat atttatacat gctttgcaac tcctacattg
    35641 ggtatgagat gggtaatgat atctttagga atattatcaa tagcaatgtg tccagtatta
    35701 tggtttgtaa ttaaagatgt agatattaaa gaagaaagag aagaagcagg tgaaaaaatg
    35761 tctgctggtg attttataac agtactaaaa tcaccaaata cttggctagt aggaataagt
    35821 atattctgtg tatattcatt cacagttaca atgtcttatt ttacaccata tataacatct
    35881 gtacttggag gttctgtagc attatctggt gcattagcaa taataagaca gcatggtcta
    35941 aaattatttg gagcaccatt tggaggatat tgtgcagaca aattaaaatc tcctacaaaa
    36001 gtacttttac caatatatgt atttggtata gcagtaatag ttttattcct agtattacct
    36061 gcatcaactc caatgactat attcatagct ttaacatttg tagtaggtat attaggttac
    36121 atgggaaaag gtatatatta tgcagtacaa gatgaagtaa aagttccagt taaatattca
    36181 gcaactacta taggtatagc tgcagcttta ggattttcac cagatgtatt ccaatttgca
    36241 ttaataggac actggataga tacttatggc aataaaggtt acacatatac atttatattc
    36301 caaatagcaa ttctagttat tggaatacta tcttgtttat atatattaaa ggttaaaaag
    36361 agaagagcaa gtaaattaga agcttaaata ttcaatttgg taattaagta tatataaata
    36421 caatacttat tttgatgaat gtgattgtat aaataacata aaaaatatca atagattaag
    36481 ttttataata atgtttagag aataaagtat aaaaatcaaa atgttatcaa gttttctagg
    36541 ttttaacata aagttacccc tgaaggtgta aaattgagtg gcaattatta tctattttct
    36601 tacctacata aacctattta atttaaattc taagagattt taaaaataga tggtagttgt
    36661 actcaatttt aaacctcata ataaatacga aaatttaaaa tctaactaga tactatttaa
    36721 ttatatatta ataaatatat attgtactat ttatataata ataatttcag gcttttcatt
    36781 atatgtattc caatttatat tgtttgatta ttattcaaac acacgtcgtt aaaaatttta
    36841 taaatttatg tttagatatg attaatactc ttgattttag aaataaatat ttgtagattg
    36901 tagattaaag ataatataaa taaatagaag gtagattttt tagatatatt aatataaaga
    36961 ttatataaaa tattgaaata tagctgttta aattattgtc tataaatata aaatgaatgg
    37021 tggtgagtta agtgaccgat ttagttaaca ccattaatgg aattgtttgg tcacccgtat
    37081 tagttgcaat gtgtttgtgt ataggattat atttttcatt gaaattaaaa ttttttcaaa
    37141 taagagatgt aaaagaaatg tttactctct tgcttgaagg agatagttct catgttggta
    37201 tatcatcatt tcaaggtttt gctacatcta tggctggaag aatagggact ggaaatatag
    37261 ctggtgtagc tgtagcaata gcaatgggag gtccaggagc attagtatgg atgtgtataa
    37321 tggctacatt aggttcagca actgcatttg tagaatctac tctagctcaa atatataaag
    37381 atgagcatga tgggcagtat agaggaggac ctccatatta ttttgaaaaa ggtcttgggt
    37441 ggaaaaagtg ttcagtttta ttttcaatag ttgcaataat aagttataca ttttttatgc
    37501 ctggtacaca atcaaacact ttatatctag caatgaatca agcatttgga ttttcaaaaa
    37561 tgacaatagc agtagcatct tctattgcat tagcgataat aatttttgga ggaattaaaa
    37621 ggattggttt atttgctgaa aaagtagtac ctataatggg tggagcatac cttattatga
    37681 cattagtaat aattataaca aatattagtt tagttccaga ggctattgta acaatgttta
    37741 aatctgcatt tggatttggt tcagtttttg gaggaatgct aggttcagca atatcttggg
    37801 gagtaaaaag aggtatatac tcaaatgaag caggagaagg ttctgggact tatggtgcgg
    37861 cagcagcaga agtgagtcat ccagccaaac aaggattagt tcaagcattt tctgtttatg
    37921 tagacacatt attaatatgt atggctacag gtattatgat tgtaataaca ggaatgtata
    37981 atgttacagg tgtttgcaca gcactgccag gtgtagaacc gggaccacaa tatgtacaga
    38041 gtgcaataaa tacattacat ccacaattag gtgatatttt tatagcaata gttttattat
    38101 tatttacatt tacaacttta ttagccttct catatatgat ggagactaat gtatcttact
    38161 tagtaactag aattaaagca gaaaaacatg aaaagtacat aattaatgtc tgtagattta
    38221 tgcttatagc atgtgcagca atgtgttgtt ttatagaacc acttacaagc tgggcattag
    38281 gtgatatatg tataggtgta ttaacatata taaatttaat tgccatcttt acactaaaaa
    38341 aaccagctat aaaggcatat tatgattata taagacagaa gaagatggga ataaaaagga
    38401 gtgatagaac ttttaaccct atagagttag atataagaaa tgctgagttt tgggaaaata
    38461 gatacttaaa agaggataag catgagttaa attaaagtta taataaaata taaaaattac
    38521 taaataaatt tagtgggagg taagattggt atgaaagaaa gaataataca agtggctgat
    38581 tcaaagaaag aaaaaattct agggctatgt caatctttat atgatgaacc agaaattgct
    38641 ttgcaagaat ataaatctgc taaaaaaata tcagaatttt taagagaaga gggttttgat
    38701 gttgaggaaa acttggcagg tatggctaca gcttttaaag caaccaagaa aaatggagat
    38761 ggtcctaaaa tagcatttat agcagaatat gatgctcttc caggcaatgg acatgcatgt
    38821 ggacatcatt taattgcatc tatgggagtt ggagctggaa tagctctttc aagtatactg
    38881 gatacttaca agggagaagt aagtataatt ggaacacctg ctgaagaaac tggagatgga
    38941 aagccttact tgatagaaca tggtgtattt gatggctatg atgcagcaat gatgatacat
    39001 ccaaattcaa aaacttgtgt aacacctgaa attatagcaa taggaggtct agatttcata
    39061 tttactggaa aagcatctca tgcaggagct aagccatata acggaataaa tgctttagat
    39121 gcagtagtat tactatataa taatataaat gcactaagac aacaattagt agatggaacg
    39181 agaatacatg gtattatact agaagcagga actgctgcaa atgtaatacc tgatatggga
    39241 aaagtaagat tagagataag ggcaaaagaa caaaattact ttgatgaagt agtagaaaaa
    39301 gtgaaaaatt gtgctagagg tgctgcaata gccactggat gtgaacttga attttatcac
    39361 tttgaaccaa cttgccaagg attaaatgaa aataaagttt tggtagacat atttacaaag
    39421 attatggagg aatttggaat atatgaagat gaacaagtaa tgttaggttc aacagatatg
    39481 ggaaatttaa gtcaaataat gccatgtata catcctttga tgaagttttc tgaaaatgga
    39541 gaagaactac atacaaaaga atttttggag gcttctataa attcatatgc aaaagataga
    39601 gtaattgatg gtataaaaat attagcttta acaggattta atttatttga aaatccagag
    39661 ttattgaaaa aaatgaagga agagtagaac ttagactatt tttaattata ctctttaaaa
    39721 taagaagagt gtctcaaaat gaacttttta gtttatgaga cactcttttt tgtatgaaat
    39781 taaatatatt tttattattt taacaatgaa aaagaggctt atctgttttt atatgacctt
    39841 ttttaacttg tagcacaaaa tatcatgaat gattacaatt cgaatgataa aatcgattat
    39901 aagatatata ggaggggtac atatggaaac tttagaagta agaaatattg aattgagtgg
    39961 tacaaattat gagataggat acagactagg agaattggtt gctaatatgc cagagataat
    40021 agaaggtcag attaataaat ctaatctggt aagcaaaaaa gaagaaaaag agatgataga
    40081 gttgtttgat aaatattgtc caggtcttaa tgaagaattg caaggttttg ctgatgcaat
    40141 tcaagtgaat tgtaatcaaa ttttatatta tactatgact tatcttaaac caggttgtag
    40201 tcaagttgca ttagcaccag aattaactga aaatgggcat gtactatttg cacgtaattt
    40261 cgatttctca cacaatatgg aggattttgt tttatgtaaa actaaggtaa atggaaaata
    40321 tgcacatata ggtactaccg ttatgcaatt tggaagaggt gaaggtatga atgaatgtgg
    40381 cttaggtgta agtcagtcat catgtggtat tcctgtaggc aattcagatg gtttaagaaa
    40441 accagcaatt gtaggtttac agttttgggc tgttattaga tatttgttag aaaattgcaa
    40501 agatgtagat gaagcattag aatatttaaa agatatgcca attgcataca atattaattt
    40561 attgcttgca gataagtctg gaaacattgc acttgtggag actttagatg ggaaaaaaga
    40621 agtaaatata atcaatagtt tagaaagtaa aagagaatat tttttacact ctactaatca
    40681 tacacatatt gataaacttc ataaattaga gccacaatca atgaaaaatt ctattcatag
    40741 atataaatta attaaagaat atataaataa gtctaaaaaa attggagaga aagagttaat
    40801 gaatttattg tcttcaaaat atccaaatgg cttatcttgt aattactata atgatttttt
    40861 tggaacttta aaaagtatag ttatggattt aaatatagg
//
LOCUS       DAEPID010000032        39704 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.032, whole genome shotgun sequence.
ACCESSION   DAEPID010000032 DAEPID010000000
VERSION     DAEPID010000032.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 39704)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 39704)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..39704
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.032"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            complement(<1..177)
                     /locus_tag="KR257_001850"
     CDS             complement(<1..177)
                     /locus_tag="KR257_001850"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861222.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0030554.1"
                     /translation="MSKIECLFTIFPVLILMYATFYFMPYFVGKKHIYGVSIDQEHKN
                     YNYFIKLDKEFKKLL"
     gene            complement(170..559)
                     /locus_tag="KR257_001851"
     CDS             complement(170..559)
                     /locus_tag="KR257_001851"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429441.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GntR family transcriptional regulator"
                     /protein_id="HBH0030555.1"
                     /translation="MVLNLDFNSDKSIYVQIKEEITKAIASGELKINESLPSVRSMAE
                     NIGVNLHTVNKSYNELKEEGFLNIDRRKGAIVAQLPMKIDNTTRQKNKLDLELLVAKS
                     YLSGISKEEFLSLSSSLFDKYEVKYYE"
     gene            751..1197
                     /locus_tag="KR257_001852"
     CDS             751..1197
                     /locus_tag="KR257_001852"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861223.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0030556.1"
                     /translation="MLTYLMKRQMHKKDDGMSKPMMITGAVITGVGAYAVYKMVKSHK
                     SNSQMVNTNYYGNSDYDDYKYDEFDYDCDCRDTKQDYEYEELKKKVKEFNSRRINCEN
                     CPHVSQEEMMQYVNSVKDVKEEIDLHEDAKKDNIYKEDEYKKYEEE"
     gene            1461..2186
                     /locus_tag="KR257_001853"
     CDS             1461..2186
                     /locus_tag="KR257_001853"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429444.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HBH0030557.1"
                     /translation="MKRKEIVMLKLLIVEDDSTISFGIKYALEQEGFSIDISKDLSSG
                     KEMISSNEYSMILLDVTLPDGTGYELCQYIRGFSQVPIIFLTACDEEVNIVMGLDIGG
                     DDYITKPFRIRELISRIKAVLRRKGNTSEENKKILKFGDLSIYTLEARVYKNDKEIFL
                     TSVEYKLLLILIQNKNTVLSRTQILEKLWDVTYDFVNDNTLTVYIKRLREKIGDDLCE
                     PIYIETVRGIGYKWIGSENSVSI"
     gene            2173..3417
                     /locus_tag="KR257_001854"
     CDS             2173..3417
                     /locus_tag="KR257_001854"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896390.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HAMP domain-containing histidine kinase"
                     /protein_id="HBH0030558.1"
                     /translation="MFLYNPEVKKFLSKYVTLMFIVIIISIGFSIINVSLTKEMVVRN
                     NQAIIGTLSSKYPNLESQIVDIITQGKSMENIDYGQKILIKYNYDKSIRINSEPIISK
                     LVLETIKINIILVCIIFILIFVLVVRYFKSIYNDLSDMTKYVYYSSEGKPFDMKNKNQ
                     EGQIGLLKTELLKMTTILNEKVELLKREKIFLNNTISDISHQLKTPMTSLIMLNDLLY
                     NDVPYEVKIDFLNKIKNQLNRMDWLIKSMLKLSKVEAKVINFKKDKVKFSELIHRAML
                     SMKIPMEIKNQKLTIEGNDNVSYIGDIDWSVEALVNIIKNCVEHTPEFGNIIITYKEN
                     PLFSELIIKDEGEGIDKKDIPHVFKRFYRGRSSSKEDSVGIGLAMSKSIIESQNGDIY
                     VNSEKGQGTEFHIIFHKMYDSD"
     gene            3497..4174
                     /locus_tag="KR257_001855"
     CDS             3497..4174
                     /locus_tag="KR257_001855"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003517588.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBH0030559.1"
                     /translation="MEILRVENLTKSYGKNETKVDAIKNVSLSVEKGTFIAITGPSGS
                     GKSTLLHLLGGVDRPTSGKVYINDVDIYNLKTKDLAIFRRRNIGLIYQFYNLIPVLNV
                     KENILLPAELDNRDIDREYFDDLMKTLGLIDREKHLPNQLSGGQQQRTSIGRALINRP
                     SIILADEPTGNLDSKNSKEILELLKLSVKKYNQTLIMITHDKNMALQADRIISIEDGI
                     IKSDEVM"
     gene            4175..6736
                     /locus_tag="KR257_001856"
     CDS             4175..6736
                     /locus_tag="KR257_001856"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419912.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBH0030560.1"
                     /translation="MNLYTLLTIRYLKQNKRRTIVTIIGIILSTALICGIGNIFESFM
                     DYQMRETIKNDGSFHVTFYDVNRKNVEYVTKSAEIEKHAFTKQLGYSKLENSENAILS
                     IKQYDKNAINGYKVSIKEGRFPAKEGEIVLSESIINLIDDKLKIGDKITLKVGDMFDS
                     SKKKIDSMTFHEGDYIANEKDRTFKVVGIIEKPGFERYNGIATAIAYFNPMNNYNDTI
                     NVSVAVRNPKDVYKISNKISKNIYSNKDKEAVSDMIKYNEHLLRLQGASKYSNINNSI
                     KSIIIAVTILVIICTIATVYNSFSISINERKKQFGILNSIGATSSQIKRLVFIEGIII
                     SLIGIPIGLISGTVAIDLLFKIINKYFTESVVTKMSLQIVYNPIITIVSIIIVLLTIF
                     ISILLPAISASNISHLNVIKNTGEYKVGKIKSSRLIKMIFKTEGVLAYKNIRRNRKKF
                     IITLFSLMVSIIIFISFSGFTLLLLRGEEIRNSQRKYDLYLTAKNTARSVEDTISELE
                     DIDGIKNFELATGQYVSIRVSENKINKSKEDLIRKYYQKYKIGDSYEYDFSNNELIFP
                     GDFAVKNKINNLVQGSFNKERAIEENGVILVRKSAFEENGKKGVVELTNYKVGDTVNC
                     EYLDENALSKKVKVKILAITDEERLGLGYQNMGLQFITYDEVAKNLNLKLSKSLIFID
                     SGGSIKTKKEIEALANKNNFNFYDESASNESEKQDLKVIKIFVYGFIVVISLVSVTNI
                     LNTVSTSINLRKRELAVIQSIGVTPKGFRKMIYLESFIYGILSLLFGIPISIGIILIM
                     NKLISGVIEFSPIIPWTAIVICIVSVFIITFIAGYIPMSKLNKENIIDNIRRESI"
     gene            6927..8201
                     /locus_tag="KR257_001857"
     CDS             6927..8201
                     /locus_tag="KR257_001857"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419914.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="4Fe-4S dicluster domain-containing protein"
                     /protein_id="HBH0030561.1"
                     /translation="MITISHITAKNMYKSLEERINKFPQGAPPSDTLYKILNVLYTEQ
                     EAKLVAQLPIKPFRVKTAAKIWSVSESEAYRVLDKLASKALILDIEDNKGKKYIMPPP
                     MAGFFEFAMMRTRHDIDQKLLAELYYQYMNVEEDFIKDLFYSTETKLGRVYVQEEVLT
                     NDNEVSILDYERATHIIDESTHIGISMCYCRHRMQHVGKACDAPMDICMTFDNVANSL
                     INNKFARRVDKIECKELLHQAYEHNLVQCGENVRKGVTFICNCCGCCCEAMVAAKRFG
                     NLHPVQTTSFIPNINHENCVKCGKCITACPIDAISKVKEDGKEYIKIDEDRCLGCGVC
                     VRNCHKNSIMLLKRDEKIITPANSVHRAVLMAIEKGQLQNLIFDNNALASHRAMGAIL
                     SAILKLEPAKKILASKQLKSVYLDKLLSMNDK"
     gene            complement(8362..11403)
                     /locus_tag="KR257_001858"
     CDS             complement(8362..11403)
                     /locus_tag="KR257_001858"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419918.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell wall-binding protein Cwp20"
                     /protein_id="HBH0030562.1"
                     /translation="MFKQRLSKLLSSTLVLSMLFTAAPNITFADNTKDNSEKYQSSDI
                     ELHDYSKNAESYTKTKALAKEKIQTLLSKYGAVSAQYALIDNGKIEISGNGGVYSKQD
                     NKNLNKDNMYSIASISKMFTTTAVMKLVDDGKLNLDTPVVKYIPEFKMADDRYKEITP
                     RMLLNHSSGLMGSSFKNTILLADNDSYGHDNFLKELQKQRLKAKPGAFSVYCNDGFTL
                     AEILVERVSGMSFTNFLDKYINNPLNLQNTKTPENSFDSSKLAKAYVPYWEDAVPQDN
                     LNAIGAGGLYSSAENLCTFAQTFMKNSNGILSPASVKAMENKEYLNGLWPEGEDSILG
                     YGLGWDCVNTYPFNQYNLKALTKGGDSLLFHSNLIVLPDENMAVAVLSSGGSSQLNEI
                     IGQEILLSALKEKGKIKEIKPDKTFSKPQQVKMPSSLKENSGLYASSNMIKVDVNDNG
                     TLTVSSPYIENGPEDKYVYIGQDRFVSEKGNSCLKFVKEKNNITYLNMSSYDDVPGLG
                     QTASLYYVAQKVDDNNISNSVKEVWKKRSGKGYYLVDEKYTSQSYMFGSVKASFSLSD
                     ETPGYIVNTKIMDENNSNAFIEIPGVIGRDLSDIKLHKENGTEYLSFGTLTYVSEDSI
                     TNLPAEKSFTCELESNGYAKWYKIGDDIANKKIEVNLPQNSAFAVYDDKGVPVNYSLV
                     TKNNRVRLPKGGVIVFLGSPNARFEVTYQDEVNASALTGTDRYETSIKISQAGWENAE
                     NAVLINDSAIADALAATPFAYKKNAPILLTGSSQINEKTLAELKRLKVKNVYVVGGEA
                     SINEKSLDTIKSNNISVSRISGSDRYQTSMNIAKELNNISNISKISVVNGEKGLADAV
                     SIGAVSAQNDMPIILTNENSNITEINNLFKNKKIDKSYVIGGEYTVSKNIESKLQNPQ
                     RISGSTRNETNAKVIKEFYKDSKIDNLYVAKNGMNKQDDLIDGLSVGVLAGKTKSPVM
                     LVGNSLDYNQKELFKTMRFKSVTQIGGNGNENSFKQIKEIA"
     gene            11610..11909
                     /locus_tag="KR257_001859"
     CDS             11610..11909
                     /locus_tag="KR257_001859"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429454.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="rhodanese-like domain-containing protein"
                     /protein_id="HBH0030563.1"
                     /translation="MYKNINKKQLKEMMKNEKDVLLLDVRTKDEFKEYKIENAINISL
                     QELINNIDEIYDYKDKKVVVYCRSGHRSVTACNLLAEEGFEHLYNLNSGIIDYMS"
     gene            complement(12147..14375)
                     /locus_tag="KR257_001860"
     CDS             complement(12147..14375)
                     /locus_tag="KR257_001860"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438668.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YhgE/Pip domain-containing protein"
                     /protein_id="HBH0030564.1"
                     /translation="MRHLKKTNSLKEILNWNNIKNLRPSKGLKNILEIFKSDLKDIRG
                     NYAVLVIVLGLAFLPSLYAWFNIKASWDPYGSTANMLVAVTNEDKGNEIAGQKINVGD
                     QLIEQLKDNKSLGWQFVDEKTALEGVKKGTYYASLKIPKNFTKDLTSLITDDVKKGEI
                     IYTVNEKINAVAPKITDKGASTIQLQVNQTIVKTVSEIVLGISNGVGAGIEHSLPKLT
                     KVENSLIDLQKRFDHINKTVDLASDATSKLSDTVKDIKSDLPTIKKTLNDTKLLSSDL
                     KKFLEDTNDNLDELSPLIKSDLNLMVDLSSSASSLTLNLIDAVNSGSEDVPKLIDNLS
                     EKLSNLQSLNDTLVDFLTKLNQLTSNNRLDDVIDNLEDSSNKIDSSISTLNDIKNKVI
                     SGQQPSISALNNVLSLSNGIGRINLNILNNFDSKISKPINSIFANSIKVANDIITVLD
                     KAEAKLPKVEEILTTSLKLSGNAQESISLIRERLPLAKGMLDDLIDTLSKISNGEDMK
                     KLVSLLESDILTKSNFLKEPVEVKTEKLYPIENYGSAMTPFYSVLSTWVGILLISALL
                     STSVHGNYKPYEIYFGRGLTFLSIALVQGFIIGTGDILLLGVTAKHPILLIVLLMFTS
                     MVFNFIVYSLVSVFGNVGKAIAIVLLVVQIGSSGGTFPIQVTPTFFQRINPIMPFTYA
                     IGATREAVGGIYAPNLTKDILVLLLFMILSICLNVLLKGPINRVIKPFNDKFGDSNLT
                     GH"
     gene            14668..16443
                     /locus_tag="KR257_001861"
     CDS             14668..16443
                     /locus_tag="KR257_001861"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902522.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBH0030565.1"
                     /translation="MRYFKKYIKKYIVLFLTAVFFLTLEAFCDLAQPTIMAKIIDIGV
                     SNKNLDYILSTGAIMIGITFLGAIFAIIRSVISARVSQHFSYDLRQDVFEKINTYSLK
                     QIDKFGRASLITRITNDINQMQQFVNGMMRVFIKSPIMCIGSLIIAIKLNLKMSIIIL
                     IAVLIIFIIILLNMKIGYRLFKNVQESTDKVNSKLRQFLSGIKVVKLFCRYDYENQSF
                     EELNDELFKNSRKATTMMSFFRPTITIIINVSIIIILLIGRHLIYSGEIKIGIIVAYV
                     NYMTRILTSLIMISHVFNVFVRAKASYERISEVLVDENEEVIEREESLDVGEKDLKFV
                     NCDIIFENVDFSYNKNTDEKILKNVSFKIEEGQNIGVIGQTGSGKTSLVNLIQKLYII
                     DKGDIKIGGRSIYSISEESLRARIGVVFQNSSVFGKSILENVVMGNRDICKEDVVKSC
                     EIANANQFITKLENTYDEVLFQRGKNLSGGQRQRITIARAIAKKPQILILDDCFSAMD
                     INTETIIRKNIKEYISNLREKESKKCTVITISQKISSIIDCDKILVLDEGEVVGFATH
                     EDLLVSSPIYKKIFALQNLVSEDVN"
     gene            16456..18279
                     /locus_tag="KR257_001862"
     CDS             16456..18279
                     /locus_tag="KR257_001862"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728676.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBH0030566.1"
                     /translation="MNLSTGNQKVSRLKKKEKPKDFKKTFKRIFMYFKKDKKITRFIF
                     LLVIIDSIISTVIPYTIGKVVDIIDIDTYSKSIFLKGIIILLSFYIIEFSVKLSKGIC
                     TARLSQSIVREMRSNLFLKFKNLPITFFDKSSTGDIMSRVTNDVDNISTGISNSLVQL
                     ITGILNILMTFIMMFVLSPILTFCSVILIPIVMFVSNFIAKRTRVFFKQQQVELGKLN
                     AHIEEMISNINVVKSFNYERKSVNDFKEVNDRLLNISLKSQIYTSLLMPIMNVISNIG
                     FATICIIGGILASKDIITIGVIASFLSYVRQFTRPLNELANLFNTLLSAIAGCERVFE
                     IIDEQEEQEVHNMFKSEINDNKDGNLNSHFVKGEIELKDVSFSYDSKKKILDNINLKI
                     KSGTSNAIIGETGSGKTTIINLITNFYHIDEGSIFLDGKDIYSINRNYLRTCFGVVPQ
                     EGYIFNDTVMENIRYGNLEATDEEVIYASKIANAHKFIVKMREGYSTVLSDRGEDLSE
                     GQKQLISIARAVLKNAPILILDEATSNIDIATEAKIQEAINNLTYGKTSIIIAHRLST
                     ISNCDNIIVLENGRIVESGNHKELIKLKGHYYRNILLTQGK"
     gene            18397..18942
                     /locus_tag="KR257_001863"
     CDS             18397..18942
                     /locus_tag="KR257_001863"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012816134.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NADH peroxidase"
                     /protein_id="HBH0030567.1"
                     /translation="MKKFVCTVCGYIHEGDAAPAQCPVCKVGADKFEEMKGEKNWADE
                     HRIGVAQGVDEEIIEGLRANFVGECTEVGMYLAMSRQADREGYPEVGEAYKRIALEEA
                     EHAAKFAELLGEVVVADTKENLRVRVDAEYGATDGKLKLAKKAKELGLDAIHDTVHEM
                     CKDEARHGKAFLGLLNRYFGK"
     gene            19202..19810
                     /locus_tag="KR257_001864"
     CDS             19202..19810
                     /locus_tag="KR257_001864"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434135.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dienelactone hydrolase family protein"
                     /protein_id="HBH0030568.1"
                     /translation="MVDNLIKYIHKSYVAIVVLHEIYGINSFIEDVCQKYYKYGYDVF
                     CPELLGEKRVFPYSKVQEAYDFFINNVGFDIYKKVEKLINDLKSEYKYVFVAGYSVGA
                     TIAWRCSEDSFCDGIICCYGSRIRDYMDVIPKCPTLLVFAKHDSFDVDSISYQLSRKQ
                     NIQIEILDANHGFIDRYSNNYSDIQTKVFTIKEKSFLSKYLA"
     gene            20137..23034
                     /locus_tag="KR257_001865"
     CDS             20137..23034
                     /locus_tag="KR257_001865"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434134.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="EAL domain-containing protein"
                     /protein_id="HBH0030569.1"
                     /translation="MKAFKKHFLILSLIFLLIISCFNNILCFADESENSKKIRVGYCD
                     DYGIISSSKEHSYTGYGYDYLREISKYTRWEYEFVKGSWEECLDRLEKGEIDLLGPLQ
                     KNDERNKLFNFPKLNSGYEYSVLYTKDSNNNMFYEDISSFKGMRVAVLRGNFHNIAFE
                     KYREENNFSVEYIYCNSIDELIESVNEKKADAFVCGSIINAKGMKIVSKFSVEPFYFA
                     TAKYKPNLVKELDYALKELKINDMYYELELYKKYFKREVNNSIAFTRQEMNFIKANPK
                     LTMVYDSEWSPVEYYDKESNSFKGISSNLMSIISKKCGIKFEYIKTKNYNESLDYIKS
                     GKANMLCGSINENDKAKRFNMKLTNPYINIPMIMVGKLDTNLNNDLNIALTSSYKSID
                     SYIEKSFENAKTTSYKSIESCLNAINEGKANLMILSSYQFDELLREGKSENLSVISVL
                     DTSYGMRIGVSNKTDPILVSILNKSIDKITEEELSDCIYSNTIDKPYKVPFGVIFKEY
                     SIQIISFVCILFLIAIKYIIYNKKKKEDYLKKIAYTDPLTGADSIDKFKINSNKLFAK
                     NNPEEYALFYIDVDKFKYINDMFGYDMGNDTLIHISNTIASELKEDEIFARVSADHFV
                     LLIKYKTDDDIKTRLNNIYNKVQILSNPKINYYKLILDCGIYKISKSDNDINTIMDRA
                     NTARKTIKGGHKNSFAFYDKEMHKKILKEKEIENSMVDALNNGEFIVYFQPKYSLSDY
                     QIIGAEALVRWDNPQKGLIPPIEFIPVFERNGFIVNIDFYVFEEVCKKIREWMDEGQK
                     VVPISVNLSRMHFVNSNFIEKFKLIVDKYKIPTRLIELELTETAVLDNIEGLLDTMNN
                     LKEKGFVISMDDFGTGYSSLNLLKELPVDILKLDRAFFTEKDESNNEKIVISNVIKMA
                     KELKMKVISEGVETISQVEFLKQIGCDMVQGYLFSKPMPVKEFEKIAFKKE"
     gene            23354..23566
                     /locus_tag="KR257_001866"
     CDS             23354..23566
                     /locus_tag="KR257_001866"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419939.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ferrous iron transport protein A"
                     /protein_id="HBH0030570.1"
                     /translation="MMPLILSNTGEEVVIKKISGSDKTRTFLNSIGFVVGTNVKIVSK
                     IDGNLIIDVKDTRVALDKKMASRIII"
     gene            23579..23800
                     /locus_tag="KR257_001867"
     CDS             23579..23800
                     /locus_tag="KR257_001867"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419941.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ferrous iron transport protein A"
                     /protein_id="HBH0030571.1"
                     /translation="MNRLKDIKCGETVKVKKLEGEGATRRRIMDMGITRGVNIFIRKV
                     APLGDPIEVTVRDYELSIRKSDAEKIIVE"
     gene            23900..26056
                     /gene="feoB"
                     /locus_tag="KR257_001868"
     CDS             23900..26056
                     /gene="feoB"
                     /locus_tag="KR257_001868"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896412.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ferrous iron transport protein B"
                     /protein_id="HBH0030572.1"
                     /translation="MSIKIGLIGNPNCGKTTMFNGLTGSSQYVGNWPGVTVEKKGGKL
                     KGNKDVEIVDLPGIYSLSPYTLEEVVTRNFMLDDKPDAVINIVDASNIERNLYLTTQV
                     LELGIPTVIALNMMDIVNKNGDKINIKELSEVIGCPVVEVTAVKGQGIMEAAEKAVEL
                     ASSNNKLNFKLPFVDESKDAIEKIEKIIEEKTPYIDVETRWLAIKLFERDENVIQKLD
                     ISKTILNSIEEITRNCEDELDDDSESIITANRYEFISSIISSIIKKNRKGKETVSDKI
                     DKIVTNRILALPIFALIMWGVYYIAVSSLGTIATDWTNDVLFGEIIQGNVSNFLASLN
                     VAEWLQGLVVDGLIGGVGAVLGFVPQIMLLFLLLSILEDCGYMSRVAFIMDRIFRKFG
                     LSGKSFIPMLISSGCGVPGVMSTRTIENDRDRKMTIMLTTFIPCGAKIPIIALFAGAL
                     FGGASWVAPSMYFLGIAMIIICGIILKKTSLFAGEPSPFVMELPQYHIPSAKGVLIHM
                     WDRGKAFIIKAGTIIFVACGVIWFLQSFNWSLQMVDAGDSILASLGNIVAPIFAPLGF
                     GNWQSSVATVTGLVAKENVVGTFGVLFGISDATEQDPTLLASVASMFTVASAFAFMAF
                     NMLCAPCFAAIGAIKREMGSWKWTWITLGFQTLTAYIIALLINQVGSLVLGTGGSIAG
                     AIISIFIAVAVVFVVLTYSNKNMKKEKMGKLSYMKN"
     gene            26082..26234
                     /locus_tag="KR257_001869"
     CDS             26082..26234
                     /locus_tag="KR257_001869"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419945.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="FeoB-associated Cys-rich membrane protein"
                     /protein_id="HBH0030573.1"
                     /translation="MATFIIAAIVVVLMALAVMYMVKNSKKNGSSCGCGCSGCSSSKS
                     CHSAKR"
     gene            26414..27124
                     /locus_tag="KR257_001870"
     CDS             26414..27124
                     /locus_tag="KR257_001870"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003427471.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AIM24 family protein"
                     /protein_id="HBH0030574.1"
                     /translation="MFKFDVTNELMCIARGSGKFFAKKGAMVAFKGNFNFEKLLLGPS
                     NGGGLGRALLGHVQRSLTGEQMPIMVVEGEGEIYLAQNAYHVDVISIDPGDSIYVESE
                     NLLAFSEQLNYSVKLIGSGVISQKGLFTTHLVNKTGQNQDVAIITDGNPLILEGPCCV
                     DPDALVAWTGREPYPKVSKLSWKTFIGQTSGESYHMEFVEPGQIVIIQPSERLSGLKT
                     DSTPSDRMSSGGLRLGID"
     gene            27209..27979
                     /locus_tag="KR257_001871"
     CDS             27209..27979
                     /locus_tag="KR257_001871"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421601.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBH0030575.1"
                     /translation="MFEKIHKRLKGYYIFLIILILWKIVCVLGIWSSYILPPPEIVLD
                     TFIKMIYDGSIFLNVYASVRRILIGFLISSLMAIPLGVLFGVNKKMYEYFKPLFEFMR
                     STPPLALVPMLILWFGIGEESKIIIIILASFFPIFLNTLKGIKNCDNKLIEVGKSFNL
                     SKKRIFYKIIIPNSMLDIVVGLSLGLGYSFRAIIGAELIAASSGLGYLISDGKDMSRT
                     DVVLVGIFVIGFLGILSDYLFSKIITKFSKGKQVDLNG"
     gene            27972..28703
                     /locus_tag="KR257_001872"
     CDS             27972..28703
                     /locus_tag="KR257_001872"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424657.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBH0030576.1"
                     /translation="MVRSGFLLENIYKKYLVDNKEHLVLDNISLNISSEEITVILGES
                     GCGKTTLLRILAGLENATSGNIYFFNNDKKCTPKVGMVFQESRLMPWLNVSENILLHT
                     EKDNRNKVDLDKYLKMMKLEKFKNSYPNELSGGMAHRVSIARALSFNPDILLMDEPFA
                     ALDYFTRRKMQKEVVNIHKNTKKGVVFVTHNIEEAMEIAKKIIVFSKNKRIKQFSVED
                     EYNRDLTKNYYINLKKEILRELGEF"
     gene            28737..29696
                     /locus_tag="KR257_001873"
     CDS             28737..29696
                     /locus_tag="KR257_001873"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012816136.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NrtA/SsuA/CpmA family ABC transporter
                     substrate-binding protein"
                     /protein_id="HBH0030577.1"
                     /translation="MTSLIMVLVGTVGCSTTNDKKDEPAKKEASLPKEINLTYVKSPL
                     NVPSILEKKDDLFGKEFKKDNIKVNFHELTTGPEQTQALAAGELDFLHALGGTSAIIA
                     ASNGVGLKITNIYSRSPKGYMLITNNDNIKSIKDLKGKKIVGPKGTILHQLLIAALAK
                     EGYTIDDVEYVNMDIPSAASALESKSADVAMLAGPVALKTINSGAKMIVNGEGLVSGI
                     IVTAVSDDFAEKYPELVKRFMKVHEETLKYMNENKDEVMDVVSKEVGLSLDETKEMYS
                     WYDFSSKITDKDIKELEDTQEFLMSNGMQQKKINIKDMLYNQN"
     gene            complement(29794..30390)
                     /locus_tag="KR257_001874"
     CDS             complement(29794..30390)
                     /locus_tag="KR257_001874"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889314.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3793 family protein"
                     /protein_id="HBH0030578.1"
                     /translation="MSCCNSQFCCKNKIESSYIKWLLEVLGPVFLGSKPAEIINISFT
                     DVNREEKINDIYKYLYKCKKIDFIVIDKEKKGLKILFVNKKALSEKLKCKKTVNFLKF
                     LGYKQNTNVNAYLEHLVDKLKSDVFPDEIGIFLGYPLKDVIGFMGYSNYEVSMIKYWK
                     VYGDTKQSEDTYSKFLLHRKKMRKLLDYISVDKIVSCF"
     gene            30636..31235
                     /locus_tag="KR257_001875"
     CDS             30636..31235
                     /locus_tag="KR257_001875"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434118.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0030579.1"
                     /translation="MKLKRTLFVGLALVLAIGITACTKNNEKPSENTGKNPNESVNNN
                     EGYMNYYSTSYNDYIAGLNRYSIYDTPESINNQFKDKEYPGNEKYLSDVKAAYKDSRD
                     KIQSFVTSLKKDGKTEDTELKKMNDDLIAEGERLVKDIDKRIEKLDKVSDEDMKKGQN
                     DFIKLVHGTEDVGNDIGSGFRKMIKDMNDRLGITGNNKK"
     gene            complement(31405..31872)
                     /locus_tag="KR257_001876"
     CDS             complement(31405..31872)
                     /locus_tag="KR257_001876"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896419.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0030580.1"
                     /translation="MENNTIKADDIINYCLSNLDDVLLMNSWGERAIYYNPNGILKRG
                     VYVLTIKEKDSNHDKGSLVSRPNVYRVNIGLKKETFIEMFGYIPKRPGVGQIVDMDFD
                     FTKLDTIMPHPIYSWMGWICVLSPTEKTFENFKTLIGESYNFAKQKFKKRKNK"
     gene            31983..32927
                     /locus_tag="KR257_001877"
     CDS             31983..32927
                     /locus_tag="KR257_001877"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434114.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YafY family transcriptional regulator"
                     /protein_id="HBH0030581.1"
                     /translation="MSRAERLIELMITINAKRSFTAGELAEEFSVSKRTILRDLQVLE
                     SIGFPLYSKVGAAGGYHVLKERILPPIAFSESEVKSIFFAYQSLEYYNDLPFEQETIS
                     VLKKFLNCIPNDIQYNIENIRRKFVFWTPDRHCSTPLLKELFNIVMNESTIKIEYSSK
                     QKNSVRTIVPIGLYAMNGLWYCPAYCIKSASIKEFRVDRIVKILSIENLSSKKYKVLS
                     SIHDYLKNMEVGTDYHIKINLTDEGVKRCETEFLLARGLKILSKGGYIDMYIPKSTLN
                     WVAEYFLTFGKNATIIEPIELKHLVKSKVLELYNHHCI"
     regulatory      33217..33323
                     /regulatory_class="riboswitch"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00162"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="SAM riboswitch class I; Derived by automated
                     computational analysis using gene prediction method:
                     cmsearch."
                     /bound_moiety="S-adenosylmethionine"
                     /db_xref="RFAM:RF00162"
     gene            33429..34394
                     /locus_tag="KR257_001878"
     CDS             33429..34394
                     /locus_tag="KR257_001878"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419956.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="methionine ABC transporter ATP-binding protein"
                     /protein_id="HBH0030582.1"
                     /translation="MISIKNVNKYYGKIQVLKDVSIEIESGEIFGIIGHSGAGKSTLL
                     RCINGLEEYQEGSVLVSDKEVKSLNEKQMRDLRKELGMIFQHFSLLERKTVFDNVALP
                     LECFGYSKAEIKKRVLELLEVVGISEKKNDKPRNLSGGQKQRVAIARALALNPQVLLC
                     DEATSALDPNTTKSILSLLEDINKNLGITIIVVTHQMEVIKQICGRVAIMENGEVLEV
                     GDTEEIFLRNTKGLRKLIGEESIILPKGTNIKILFPKDISNEAIITTMARELNIDVSI
                     IFGKLEQFKDDILGSLIINISDKSGEQVKQYLTSKGIRWEEMINE"
     gene            34387..35043
                     /locus_tag="KR257_001879"
     CDS             34387..35043
                     /locus_tag="KR257_001879"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419957.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBH0030583.1"
                     /translation="MNSLIDFLTTLFPNALLQTLYMVIVPTIVATILGFILAIILVVT
                     KPDGLKPNSTINSALGFIVNIFRSFPFMILIVAMIPITRLIVGTSIGETAAIVPITIG
                     AAPFIARIIESSLNEVDKGLIEAAKSFGATKRQIVFKVMIKEAMPSIVSGITLSIISI
                     LGYTAMAGAVGAGGLGNIALIYGYQRFDTAVMVYTVIALIILVQIIQGVGNLAYKKLK
                     "
     gene            35079..35870
                     /locus_tag="KR257_001880"
     CDS             35079..35870
                     /locus_tag="KR257_001880"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011987989.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MetQ/NlpA family ABC transporter
                     substrate-binding protein"
                     /protein_id="HBH0030584.1"
                     /translation="MKLKKLLSVALVSAIAISAVGCSNKEDKKILVGASSNPHAKILE
                     VAKPLLKEKGYDLEVKIFDDYVLPNTALDEGSLDANFFQHIPFLEETVKEKGYKLTYT
                     SKVHIEPMGFYSEKVKSLDELKDGAVIAVPNDATNGARALKLLAKNKLIEVKDGELIT
                     KKDITKNPKNIVIKEMNAEQLPTVLKDVDGAVINSNYALTANLNPTKDAIVIESSDSP
                     YVNIIACRENNKDSDKIKALSEAMNSKEVKKFIQDEYKGSIVPAF"
     gene            36018..38756
                     /locus_tag="KR257_001881"
     CDS             36018..38756
                     /locus_tag="KR257_001881"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896425.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PAS domain-containing sensor histidine kinase"
                     /protein_id="HBH0030585.1"
                     /translation="MESKGTLSKNKVYILANGLFLVIALLNINLYTVSINMYRIILLW
                     IFGYSIVYISSFKTDEFINILKVGCLVLVFVSILGVVNLKIQKFQIVLLNLSIINMST
                     FIYLTISKVKKLRISPILIFYSAFVILDYFIRNIFSDINWNMIIILINVCISMFNLLY
                     LLNKLDSNIEHYKLIKDLTYFVFFTTIICFVAISKINIVDSDRLIGVIYLLLCNHTYY
                     VYVYSLNNRVVYPYYELDSINKKLSKKSEQLGKINLAIEKDMIIQRTLKNYIDQRKEL
                     LRQALDTIPNVWIVTDYDFNISYTNNKFKDEFSKDMNNYYKILTFIKEDEKVAEKLKK
                     FDNDISIIDKLVELNDKIYLLSLSNNKDESNYLISLNDITNEIKIDEEIRNINKDYEN
                     IILNIPSPILVRSAEGGIKKNKVISINKKYEKSFKCVSSDLVDMTLEQYFETFNIDFF
                     DNREFKRLNLTQEKKAEIVSYNDTANCIVNFVMSDSEGEEHVEEVRVGDYWSDNKLFK
                     LLTFRDITKEINILRTVNEQKIIYEKLLDVIPEAIFLEDLSTSRVLYTNRAFRELFGI
                     SSDVLGVTTQKYRNILVKKYINNLNIGEREKSIHIVNENNHIKEVKMISRTLYFGQKR
                     SRVRIIKDLSVQRESERLKKALIKQRQYDQMKMEFYANISHELKTPLNNIYSSVQLIE
                     NLYKKGKIIDFQDILKEHIKITKQNMFRLLRLIDNIINISQVKSDIYKIKAVNFDIID
                     ITERIVTSISSYAKSKGIDLIFDTDEETVMVGLDPESIERIILNILSNAIKFTLEGGE
                     ILVGIYKKDETVEIIIKDTGVGIDKEKLNDIFNRFKQIENSGISNEFGSGIGLCLTKS
                     LIEIQNGKIYIDSKVGEGTNVKVIFPIKEVVEEVYDNSNYNDNIEKFEIEFFDIYK"
     gene            38865..39473
                     /locus_tag="KR257_001882"
     CDS             38865..39473
                     /locus_tag="KR257_001882"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003427435.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA-3-methyladenine glycosylase"
                     /protein_id="HBH0030586.1"
                     /translation="MEKDFFRKNGIDLAKSILGKYLIRKYENKVIVTKIIETEAYMGV
                     NDKGAHVYGNKKTDRTKPLYLDGGHIYVYLIYGMYNCLNLSANIENVPECVLIRGVEP
                     ITSLDEISMNRYNKAYTELSKYQVKNITNGPGKLCKALKIDRSLNSKSIMGEELYISD
                     FYYDDKGKKVFSKDELDIKTSKRINIDYAEEAKDFLWRFYIE"
BASE COUNT        15589 a         4201 c         6509 g        13405 t
ORIGIN      
        1 taatagtttt ttaaattctt tatctaactt tataaagtaa ttataatttt tatgctcttg
       61 gtctatagaa actccataga tgtgtttttt acctacaaaa tagggcataa aataaaatgt
      121 agcatacatc aaaattagaa ctggaaatat tgtaaataga cattcaatct tactcataat
      181 atttcacctc atacttgtca aataaacttg aacttagtga caaaaattct tctttactaa
      241 tacctgataa ataagatttt gccaccaata attccaagtc aagtttattt ttttgacgag
      301 ttgtattatc tattttcatt ggtagttgag ctacaatagc accttttctt ctatcaatat
      361 ttaagaatcc ctcttctttt aattcattgt aggatttgtt cactgtatgt aaatttacac
      421 caatattttc agccatactt cttacagatg gaagtgattc atttattttc aattctcctg
      481 aagctatagc cttagttatt tcttctttaa tttgtacata aatagattta tcactattaa
      541 aatctaaatt taaaaccata aaaaacctcc attatgcttt ataaatgaaa acgattgtta
      601 tatacatagt ataacataaa aaataataac aaacacaaaa tataagttta tattttgtaa
      661 aaattgtaat ttaaaaaata acataatttt tattaaaata atacagatac tatttataga
      721 tagaaataaa aattagaaag gagaaaaaat atgttaacat atttaatgaa aagacaaatg
      781 cataaaaaag atgatggaat gagtaaacca atgatgatta caggagctgt aattacaggt
      841 gtaggagcat atgctgtata taaaatggta aaaagccata aatctaattc tcaaatggtc
      901 aatacaaatt attatggaaa tagcgattat gatgattata aatatgacga atttgattat
      961 gactgtgatt gtagagacac aaaacaagat tatgaatatg aagaattaaa aaaaaaagta
     1021 aaagaattta attcaagaag aataaattgt gaaaattgtc cacatgtttc tcaagaagaa
     1081 atgatgcaat atgtaaatag tgttaaagat gtaaaggaag agattgattt acatgaagat
     1141 gctaaaaaag ataatattta caaagaagat gaatacaaaa aatatgaaga agaataagta
     1201 atattttgta taactgaaca aatagtaatg tcaaattatt taatatctag ttttaatatg
     1261 taagttgtaa cttaacttga aagaatcagt atcattcttt agatagttaa gtaacaactt
     1321 acattttatt tttataaatt ttaatagttc tttgtgacta ttttgtaatt ttagaaatat
     1381 tttagtatcc agggtaattg tgtataataa aacttgtata gatagatagt atgaaattaa
     1441 gcagatagtt taaaattaaa atgaaaagaa aggaaatagt tatgttaaag ttgttgatag
     1501 ttgaagatga tagtactata tcttttggaa taaagtatgc tttagaacaa gaaggattta
     1561 gtatagatat atcaaaggat ttatctagtg gaaaagaaat gatttcttct aatgaatata
     1621 gcatgatact gttggatgtt acattgccag atggaactgg ttatgagctt tgtcaatata
     1681 taagaggatt ctctcaggtt cctataatat tcttgactgc ttgtgatgaa gaagtaaata
     1741 ttgtaatggg tctcgatata ggtggagatg attatataac aaaacctttt agaattagag
     1801 aattaatatc cagaataaaa gctgttttaa gaagaaaagg taatacttca gaagaaaata
     1861 agaaaatact taaatttgga gatttaagta tatatacatt agaagctaga gtatataaaa
     1921 atgataaaga aatatttctg acatcagttg aatataaact tcttttaatt cttatacaga
     1981 ataaaaatac tgttttaagt agaactcaaa tattggaaaa actttgggat gtaacttatg
     2041 attttgtaaa cgacaatact ctaactgttt atataaaaag gcttagagaa aaaataggtg
     2101 atgatttatg tgaaccaatc tacatagaaa ctgtaagggg gattggttat aaatggatag
     2161 gaagtgaaaa tagtgtttct atataatcca gaagtgaaga agtttttaag taagtatgtt
     2221 actttgatgt ttattgttat cataatatct attggattta gcataatcaa cgtgtcctta
     2281 actaaagaga tggttgtaag aaataatcag gctataatag gaactttatc aagcaagtat
     2341 ccaaacttgg aaagtcagat agtagacata ataactcaag ggaagtctat ggagaacata
     2401 gattatggtc agaaaatatt aattaagtat aattatgata aatctattag gataaactct
     2461 gagcctatta tttctaaatt agttttagag actatcaaaa taaatataat attagtatgt
     2521 ataatattta ttttgatatt tgtgttggtt gttagatatt ttaagtcaat ttacaatgat
     2581 ttatcagata tgactaagta tgtttactat agttcagagg gtaagccatt tgatatgaaa
     2641 aacaagaatc aagaagggca gataggtctt ctaaaaactg aactcttaaa gatgacaaca
     2701 attcttaatg aaaaggttga acttttaaaa agagaaaaga tatttttaaa caatacaatt
     2761 tccgatatat cacatcaatt aaaaactcct atgacttctt taataatgtt gaatgattta
     2821 ttatataatg atgtaccata cgaagtaaaa atcgattttt taaataagat aaaaaatcaa
     2881 ttaaatagaa tggattggtt gattaaaagc atgcttaaat tatcaaaggt agaagcaaaa
     2941 gtgataaatt ttaaaaaaga taaggtaaaa tttagtgaac tcatacatag agcaatgcta
     3001 tctatgaaaa tacctatgga gattaaaaat caaaaactga ctatagaggg aaatgataat
     3061 gtatcttata ttggtgatat tgattggtcc gtggaagcat tagtgaatat aatcaaaaat
     3121 tgtgtagaac atactcctga atttggaaat ataattataa cctataaaga aaatccatta
     3181 ttttctgaac taataataaa agatgagggt gaaggtatag ataaaaaaga tataccacat
     3241 gtatttaaac gattctatag aggaagaagt agttcaaaag aagatagtgt aggaataggt
     3301 cttgcaatgt caaaatctat aatagaaagc caaaatggcg atatatatgt aaacagcgaa
     3361 aaaggtcagg gtacagaatt tcatataata tttcataaaa tgtatgatag tgactaatct
     3421 gtaatattta attcacttta tagtaatagc caaaacctaa tatatgaagt atagaatata
     3481 aatattggag gtagttatgg aaattttaag agtagaaaat ctaactaaaa gttatggtaa
     3541 aaatgaaaca aaagttgatg ctataaaaaa tgtaagttta tcagttgaaa aaggaacgtt
     3601 tatagcaata acaggtccaa gtggaagtgg taaaagtacc ttattacatt tattaggagg
     3661 agttgacaga ccaactagtg gtaaggttta tataaatgat gttgatatat ataatttaaa
     3721 aactaaggat ttggcgatat ttagaagaag aaatataggt cttatatatc aattttacaa
     3781 cttaattcca gtcttaaatg tgaaggaaaa catattgctt ccagcagagc ttgacaatag
     3841 agatattgat agagaatatt ttgatgattt aatgaaaaca ttaggtctaa ttgatagaga
     3901 aaagcacctt ccaaaccaat tatcaggagg tcaacaacag agaacctcta taggacgtgc
     3961 attaattaat agaccttcta taatattagc agatgagcca acaggtaatt tagatagtaa
     4021 aaattcaaag gaaatattag aattgttaaa attgtcagta aaaaaataca accagacact
     4081 aataatgata actcatgaca aaaatatggc acttcaagct gatagaatta taagcataga
     4141 agatggaatc ataaaaagtg atgaggtgat gtagatgaat ttatatacat tactaaccat
     4201 tagatactta aaacaaaata aaagaagaac cattgtaacc ataatcggta taatactttc
     4261 aacagcttta atttgtggta taggaaatat atttgaaagt tttatggatt atcaaatgag
     4321 agaaactata aagaatgatg gaagtttcca tgttacattt tatgatgtaa atagaaaaaa
     4381 tgtggaatat gtaacgaaat cagctgaaat agaaaaacat gcatttacca aacaacttgg
     4441 atattctaaa ttagaaaata gtgaaaatgc tatattaagt ataaagcaat atgataaaaa
     4501 tgcaataaat ggatataaag tttctataaa agaaggtaga tttccagcta aggaaggaga
     4561 aattgttcta agtgaaagta ttattaatct tatagatgat aagttaaaaa taggagataa
     4621 gataacttta aaagtagggg atatgtttga ctcaagcaag aaaaagattg atagtatgac
     4681 atttcatgaa ggtgattata tagcaaatga aaaagataga acttttaaag ttgttggtat
     4741 aattgaaaaa cctgggtttg aacgttataa tggaattgca acagctatag cctactttaa
     4801 tcctatgaat aattacaatg atacaattaa tgtatcagta gcagtaagaa atcctaaaga
     4861 tgtgtataag ataagtaata aaataagtaa aaatatatat tcaaataaag ataaagaagc
     4921 agtttctgat atgataaaat acaatgaaca tttattgagg ttacaaggtg ctagtaagta
     4981 ttcaaatata aataactcta taaagtctat aattatagca gtaactattt tagtaatcat
     5041 atgtacaatt gctacagtgt acaattcctt tagtatttct ataaatgaac gaaaaaaaca
     5101 gtttgggata ttaaattcta taggtgctac atctagtcaa attaaaagat tagtttttat
     5161 agaaggtatt ataattagtt taattggtat accaatagga ctaatatctg gaacagtagc
     5221 tatagaccta ttgtttaaaa ttataaataa gtattttact gaatcggttg ttactaagat
     5281 gagtttgcag atagtgtata atccaataat aactattgtt agtataataa tagttttgct
     5341 tacaatcttt atatcaattc tactacctgc aatatcggct tctaatattt ctcaccttaa
     5401 tgtgattaaa aatactggag agtataaagt gggcaaaatc aaaagctcaa gacttattaa
     5461 aatgattttt aaaactgaag gagtacttgc atataaaaat attaggagaa atagaaaaaa
     5521 atttataata actctttttt ctttaatggt aagtataata atatttatat cttttagtgg
     5581 ctttacatta cttttactaa gaggtgaaga aattagaaat tctcaaagaa aatatgattt
     5641 gtatttaact gcaaagaaca cagctaggtc tgtagaggat actataagtg aactagaaga
     5701 tattgatggg ataaaaaact ttgaattggc aacaggacaa tatgtgtcta taagagtaag
     5761 tgaaaataaa ataaataaat ccaaggaaga tttaatcagg aaatattatc aaaaatataa
     5821 gattggagat agttatgaat atgatttcag taataatgaa ttaatttttc caggagattt
     5881 tgcagtaaaa aacaaaataa ataacttagt acagggctct tttaataaag agagagcaat
     5941 tgaagaaaat ggtgttatat tagttagaaa aagtgcattt gaagaaaatg ggaagaaagg
     6001 tgtagtagaa cttaccaact ataaagtagg agatacagta aattgtgaat atcttgatga
     6061 aaatgcctta agtaaaaaag taaaggtcaa gattcttgct ataactgacg aagaacgtct
     6121 aggtcttggt tatcaaaata tggggttaca atttataact tatgatgaag ttgctaaaaa
     6181 tttaaattta aaattaagta aaagccttat atttattgat tcaggaggaa gcattaagac
     6241 taagaaggaa atagaagctt tggcaaataa aaataatttt aacttttatg atgaaagtgc
     6301 aagcaatgaa agtgaaaaac aagatttaaa ggttattaaa atatttgtat atggttttat
     6361 agtagtgata tctttagtga gtgttacaaa tattctaaat acagtaagta caagtataaa
     6421 tctaagaaaa agagaacttg cagtaataca atctataggg gttactccta aaggatttag
     6481 gaaaatgata tatttagaaa gttttatata tggtatactg tcattgttgt ttggaatacc
     6541 aattagtatt ggtataattc taattatgaa taaacttatt tcaggtgtaa ttgaattttc
     6601 tccgattata ccgtggacag ccatagttat ctgtatagta agtgttttta taataacttt
     6661 tatagcaggg tatataccaa tgagtaaatt aaataaagaa aatataatag ataatataag
     6721 aagagaaagt atatagatat aaaaataatt cttaactata taaaatatta ttatatcact
     6781 taaatgattt tttatttata taagaaatct aataataaat tactagaggt atttaactat
     6841 ttagaaagaa ttggtattat ataaagtaag agaatatata ataagaaaga atatttgatt
     6901 ttattggaaa acaaaagaaa aagaaggtga ttactatttc tcatataact gcgaagaata
     6961 tgtataaaag tttagaggaa agaataaaca agtttccaca aggtgctcca ccatctgata
     7021 cattatacaa aatactaaat gtactatata cagaacaaga agcgaagtta gttgctcagc
     7081 ttccaataaa gcctttcaga gtaaaaacag cagctaaaat ttggagtgta agtgaaagtg
     7141 aagcatatag agtattggat aaacttgcta gtaaggctct gatactagat atagaagata
     7201 ataaagggaa gaaatatata atgcctcctc caatggctgg tttttttgag tttgccatga
     7261 tgagaacgag acacgatata gaccaaaaac ttttggcaga gctttactat caatatatga
     7321 atgtagaaga agattttatc aaagatttat tttattcaac agaaacgaag cttggaagag
     7381 tatacgttca agaggaagtt ttaactaatg ataatgaggt tagtatttta gattatgaaa
     7441 gggctactca tataattgat gaatcaactc atataggtat aagtatgtgt tactgtagac
     7501 atagaatgca acatgttgga aaagcttgtg atgctcctat ggatatatgt atgacgtttg
     7561 acaatgtagc aaattcttta ataaataata aatttgcaag acgtgtggat aaaatagaat
     7621 gtaaagaact acttcatcaa gcatatgaac ataacttagt tcaatgtgga gaaaatgtta
     7681 ggaaaggggt tacgtttata tgtaattgct gtggatgttg ctgtgaagca atggtagcag
     7741 ctaaaagatt tggaaatctt catccagtac agacaacaag ttttatacca aatataaacc
     7801 atgaaaattg tgtaaagtgt ggtaaatgta taactgcatg tccaatagat gcgataagca
     7861 aggttaagga agatggtaaa gaatatataa aaattgatga ggatagatgt ctaggttgtg
     7921 gagtttgtgt tagaaattgc cataaaaata gcattatgtt attaaagaga gatgaaaaaa
     7981 taataactcc agcaaattca gtacatagag cagttcttat ggcaattgaa aaagggcagt
     8041 tacaaaattt aatttttgat aataatgctc tggctagtca tagagctatg ggagctatac
     8101 tgtcagctat attaaagctt gaaccagcta aaaagatttt agccagtaaa caattaaagt
     8161 cagtatattt agataaattg ttaagtatga atgataaata gaaactaact taaaaaaggc
     8221 aaagttttag acttatctat atcttaataa acttatcatt taatatttaa atttaatttt
     8281 tacacatata aaacttataa cttaaataaa aaaaggctat attcaattaa tattacttga
     8341 atacagcctt ttttagttat gttaagctat ttcttttatt tgcttaaatg agttttcatt
     8401 tccatttcca ccaatttgtg ttacagattt aaatctcata gttttaaata gttctttttg
     8461 attataatct agtgagtttc ctactagcat tacaggagat ttagtttttc cagccaaaac
     8521 tccaacagat aatccgtcta ttaaatcatc ttgtttattc attccatttt tagcaacata
     8581 taaattgtct atcttagaat ccttgtaaaa ttcttttatt acttttgcat tagtttcatt
     8641 tctagtgcta cctgatattc tctgtggatt ttgaagttta ctttctatat ttttagaaac
     8701 tgtatattct ccaccgatta cataagattt atcaatcttt ttgtttttaa acaagttatt
     8761 tatttcagtt atattactat tttcattagt aagtattata ggcatatcat tttgagctga
     8821 tacagctcca atgcttactg catcggctaa tcctttttcg ccattaacta ctgaaatctt
     8881 tgatatattg ctaatattgt tcaattcttt agcaatgttc atagaagttt gatatctatc
     8941 acttcctgaa attctagata cagagatatt gtttgatttt atagtatcta aagatttttc
     9001 atttatagaa gcttctccac caactacata tacattttta acttttaatc tctttaattc
     9061 agccaaagtt ttttcattta tttgagagct tccagtcaat aatataggag cgtttttctt
     9121 gtatgcaaat ggtgttgcag ccaaagcatc tgcaattgct gaatcgttta ttaaaactgc
     9181 attttcagca ttttcccaac ctgcttgact tatcttaata gaagtttcat atctatcagt
     9241 tcctgtaagt gcacttgcat ttacttcatc ttgatatgta acctcaaatc tagcatttgg
     9301 acttcctaag aaaacaatta cgcctccttt tggcaatcta actctattgt tctttgtaac
     9361 taaagaatag tttacaggaa cacctttatc atcataaaca gcaaaagctg aattttgagg
     9421 aagattaact tctatttttt tatttgcgat atcgtcacca atcttatacc attttgcata
     9481 accattggat tctagttcac aagtaaaaga tttttctgct ggcaaattag ttatagaatc
     9541 ttcactaaca tacgttagtg ttccaaaaga taaatactct gtaccatttt ctttatgaag
     9601 tttaatgtcg gataaatcac gacctattac accaggtatt tctataaaag catttgagtt
     9661 attctcatcc attattttag tgttaactat ataacctgga gtttcatcag aaagactaaa
     9721 acttgctttt acagagccaa acatatagct ttgagaagta tatttttcat ccactagata
     9781 gtaacctttg ccacttcttt ttttccacac ttctttgaca ctatttgata tattgttgtc
     9841 atctactttt tgagctacat agtataaact tgctgtctga cctaatccag ggacatcatc
     9901 ataagagctc atatttaaat atgtgatatt atttttttct tttacaaatt ttaaacaact
     9961 attacctttt tcagatacaa atctatcttg acctatgtat acgtatttat cttcaggtcc
    10021 attttctata taaggagaag atactgttaa agtaccatta tcattaacat ctacttttat
    10081 catatttgaa gaagcataaa gaccactatt ttcttttaaa gagctaggca ttttaacttg
    10141 ttgtggctta ctaaatgttt tatcaggttt tatttcttta attttacctt tttcttttaa
    10201 tgcagatagt aagatttctt gtccaattat ttcattaagt tgactacttc caccagaaga
    10261 aagaactgca actgccatat tttcatctgg aagaactata agattactgt ggaataataa
    10321 agaatctcca ccttttgtaa gagcttttaa attatactga ttaaatggat aagtgttgac
    10381 acaatcccac cctaaaccat atccaagtat agagtcttct ccttcaggcc atagaccatt
    10441 taaatattct ttgttttcca tagcttttac tgaagcagga gaaagaatac catttgaatt
    10501 tttcataaat gtttgtgcaa atgtacatag attttctgca cttgaatata aaccacctgc
    10561 acctatagca ttaaggttat cttgtggaac tgcatcttcc caataaggta catatgcttt
    10621 tgctagtttt gaactatcaa aactattttc tggagttttt gtattttgta agttaagtgg
    10681 attatttatg tatttatcaa gaaaattagt aaatgacata ccagatactc tttctactaa
    10741 aatttcagct aaagtaaatc catcattaca ataaacagaa aaagctcctg gtttagcttt
    10801 taatctttgt ttttgtaatt cttttaagaa attatcatga ccataagaat cattgtctgc
    10861 taataaaata gtgtttttaa aactacttcc catcaaccct gatgagtgat ttaataacat
    10921 tcttggagtg atttccttgt atctatcatc agccatttta aattcaggta tatactttac
    10981 aacaggagta tctaaattta attttccatc atcaaccaac ttcataacag ctgttgtagt
    11041 aaacatttta ctgatagatg cgatactata catattatcc ttatttaagt ttttgttatc
    11101 ctgtttgctg taaactccac cattaccaga aatctcaatt ttgccattat caatcaaagc
    11161 atattgagca cttacagcac catactttga tagcaaagtt tggattttct ctttagcaag
    11221 agctttagtt tttgtgtaag attccgcgtt tttactataa tcatgtaatt ctatatcaga
    11281 actttgatat ttttcggaat tatcttttgt attatcagca aaagtaatat ttggagcagc
    11341 agtaaataac atactcaata ctaatgtact agataataat ttagagagcc tttgcttaaa
    11401 catattacat tacctctttc cctttttaat aatttataat tagcataaca ttcttaatta
    11461 ttttaatcaa cagattatta tcaataaaaa aagcttttat aagtatagct ttttatataa
    11521 cagagaaaaa tataaaaata atatttgttg ttgtataaag aataaagggt ataggtaata
    11581 tataaataaa atggaggaat tttagacata tgtataagaa tataaataag aagcaactta
    11641 aagaaatgat gaaaaatgaa aaggatgttt tattattaga tgtaagaact aaagatgaat
    11701 ttaaggaata taaaatagaa aatgctataa atatatcttt acaagagtta atcaataata
    11761 tagatgaaat ttacgattat aaagataaga aagtagtagt ttattgcaga agtggtcata
    11821 gaagtgttac tgcatgtaat ttgttagctg aagaaggttt tgagcattta tataatttaa
    11881 attcaggaat aattgattat atgagttaaa taatgtaagt tatacattaa atactatgta
    11941 tagctctgct tattaagtag gaatatatct aaatatttat aagataaatt taggaaagaa
    12001 cgaatttttt cgtttttttc tatgacagtt tttgtagtaa atattagttt ttaagttgga
    12061 aaaaggtagt agctttttag ctactacctt ttaatatgaa cttagaatat tattaaaaaa
    12121 atatatttaa agacagaatt aattttttaa tgaccagtta aattactatc gccgaattta
    12181 tcattaaatg gttttataac tctatttata ggtcctttta gaagtacatt taaacaaata
    12241 gacagaatca taaatagtaa tagaactagt atatctttag ttagatttgg agcatatata
    12301 ccaccaactg cttcccttgt agcacctatt gcataggtaa atggcattat agggtttatt
    12361 ctttggaaga atgtaggtgt aacttgtata gggaatgtac caccagaaga accaatctga
    12421 acgactaata gtactattgc aattgctttt cctacatttc caaatacaga aactaaagaa
    12481 tacactataa agttaaatac catactagta aacataagca gaactatcaa taaaattgga
    12541 tgttttgctg ttactcctaa caataatata tctccagttc ctattataaa accttggaca
    12601 agagctatac ttaaaaaagt aaggcctctt ccaaagtaaa tttcataagg tttatagttt
    12661 ccatgtacag atgtagacaa tagtgctgaa ataagtaata taccaaccca tgtagaaaga
    12721 acactataaa atggtgtcat tgcagaacca taattttcaa ttggatataa tttctctgtt
    12781 ttcacctcaa caggttcttt taagaaatta gactttgtca atatatcact ttcaagcaag
    12841 ctgactaatt ttttcatatc ttcaccatta ctaattttgc ttaaagtatc aatcaaatca
    12901 tccaacattc cttttgctaa aggaagtctt tctcttatca atgatatact ttcctgtgca
    12961 tttcctgaaa gttttagaga agtagtaagt atttcttcaa cctttggaag ttttgcttct
    13021 gccttatcta aaacagtaat tatatcattt gctactttta tactgtttgc aaatatacta
    13081 tttataggtt ttgatatttt tgagtcaaaa ttatttaaaa tatttaaatt aattcttcca
    13141 ataccatttg atagacttaa aacattattc aaagcactta tagatggttg ttgtccagat
    13201 ataactttgt ttttaatatc atttaatgtt gatatagatg aatctatttt attgctagag
    13261 tcttcaagat tatctatgac atcatccaat ctattatttg atgtaagttg gtttaattta
    13321 gttaaaaaat ccaccaaagt atcatttaaa gattgcaaat tagaaagttt ttctgataaa
    13381 ttatctatca acttaggtac atcttcactg ccactattta ctgcatcaat taaatttaat
    13441 gtaagagaag aagcagaaga tgaaaggtca accattaaat ttaagtcaga cttaataaga
    13501 ggagaaagtt cgtctaaatt atcatttgta tcctctaaga atttttttaa gtcacttgat
    13561 aatagttttg tatcattcag agtcttttta attgtaggta aatcagattt aatatcttta
    13621 actgtatcag ataattttga agtagcatca gaagctaaat caacagtctt atttatatgg
    13681 tcaaatctct tttgaaggtc aataagggaa ttttcaactt ttgtcaattt tggaagactg
    13741 tgttcaattc ctgcaccaac tccgtttgat ataccaagaa cgatttcact aactgttttt
    13801 actatagtct gattaacctg tagttgtatt gtagaagcac ctttatctgt aatctttggt
    13861 gcaactgcat ttattttttc attaacagta tagataattt cgcctttttt aacatcatct
    13921 gtaattaaag atgtcaaatc ttttgtaaaa ttttttggaa tcttaagtga tgcataataa
    13981 gtaccttttt taacaccttc aagagcagtt ttttcatcta caaactgcca acctaaactc
    14041 ttgttatctt tgagttgttc aattaattgg tctcctacat taatcttttg tcctgctatt
    14101 tcatttcctt tatcttcatt tgttactgct acaagcatat tagcagtgct tccataaggg
    14161 tcccaagatg cctttatatt gaaccaagca tacagagatg gtaaaaaagc aagacctaaa
    14221 actattacaa gtacggcata attgccacgt atatctttta ggtcactttt aaaaatttct
    14281 aatatatttt ttaaaccctt tgaaggtctt aaattcttga tattattcca gtttaaaatt
    14341 tcttttaaac tattagtttt tttcaaatgt ctcacctcct aaaatatttt gataaagaaa
    14401 aaagttagat ttataatcaa ttttaaatta tattactttt tacacaaata gtaaagttaa
    14461 aattttgtct taattttaat acatatatat tatatataat agtatgctat aaatatatat
    14521 aaatatagga aataaaaaca aataatttat aaaatatatg gtataaaaat taataataaa
    14581 tcaaatattt ataattgata taatcaatta aattagccat tatgatatac ttttggtaat
    14641 gagaaaattc tatgaaggga tgattgaatg aggtatttta aaaaatacat aaaaaaatat
    14701 atagtattat ttctaacagc agtatttttt ttaacattgg aagctttttg tgatttagct
    14761 caaccaacta taatggcaaa aataatagat ataggggttt caaataagaa cttagactac
    14821 atactatcaa caggagctat aatgataggt ataacttttt taggtgcaat atttgcaata
    14881 ataagaagtg taatctcggc aagagtttct cagcattttt cttatgattt aagacaggat
    14941 gtatttgaaa agataaatac atactcatta aaacaaatag ataaatttgg tagagcttca
    15001 ttaataacaa gaattactaa tgatatcaat caaatgcaac aattcgttaa tggaatgatg
    15061 agagttttta taaagtcacc aataatgtgt ataggaagtt taattatagc tataaaatta
    15121 aatttaaaga tgtcaataat tattctaatt gcagttttaa ttatatttat tataatattg
    15181 cttaatatga agatagggta tagattattt aaaaatgtac aagaaagtac agataaagta
    15241 aattcaaaat taagacagtt tttaagtgga ataaaagtag ttaaactatt ttgtagatac
    15301 gattatgaga accaaagctt tgaagagtta aatgatgaac tttttaaaaa tagtagaaaa
    15361 gctacaacta tgatgtcatt ttttagaccg acaattacaa taatcattaa tgtttccata
    15421 ataataatat tactgattgg aaggcattta atttattcag gagaaattaa aattgggatt
    15481 atagttgctt atgtaaacta tatgactaga atattaacat ctcttataat gatttcacat
    15541 gtttttaatg tttttgttag ggcaaaagca tcttatgaga gaataagtga ggttttggtt
    15601 gatgagaatg aagaagtaat tgagagagaa gaaagtttag atgttggaga aaaagattta
    15661 aagtttgtaa actgtgatat aatttttgaa aatgtagatt tttcgtataa caaaaataca
    15721 gatgaaaaaa tattaaaaaa cgtatccttt aaaatagaag aaggtcaaaa tattggtgtg
    15781 attggtcaaa ctggttcagg aaagacttct ttagtaaatt taattcaaaa attatatata
    15841 attgataaag gtgatattaa gattggagga cgtagtatat acagtatttc tgaagaaagt
    15901 ttaagggcaa gaataggtgt agtatttcaa aatagtagtg tgtttggaaa aagtatattg
    15961 gagaatgtag ttatgggaaa tagagatata tgcaaagagg atgttgtaaa atcatgtgaa
    16021 atagcaaatg caaatcaatt tataacaaaa ctcgaaaata cttatgatga agttttattc
    16081 caaaggggta aaaatttatc aggaggacag agacaaagaa ttactatagc tagagctata
    16141 gccaaaaaac cacaaatatt aattcttgat gattgtttta gtgcaatgga tattaataca
    16201 gagacaatta taagaaagaa tataaaagag tatataagta atttaagaga aaaggaaagt
    16261 aagaaatgta ctgtaataac tatttcacaa aagattagtt ctataattga ctgtgataag
    16321 attttagtct tggatgaggg tgaggtggtt ggatttgcta cacatgaaga tttactggtt
    16381 agttctccaa tttataaaaa aatttttgcg ttgcaaaatt tagtaagtga agatgtaaat
    16441 taaggaggaa gtatattgaa tttaagtact ggaaatcaga aggtcagtag attaaagaaa
    16501 aaagaaaagc ctaaagattt taaaaaaacg tttaaaagaa tttttatgta ctttaaaaaa
    16561 gataagaaga ttactagatt tatttttttg ctagtaataa ttgattcaat tatatcaact
    16621 gtaataccat atactattgg aaaggtagtt gacataatag atatcgatac ttattcaaaa
    16681 tccattttct taaaaggaat aattatttta ctttcatttt atataattga gttttcagtt
    16741 aaactgtcta agggaatatg tacagctaga ttatctcaaa gtatagtcag agaaatgaga
    16801 agtaatttat ttttaaaatt taaaaatcta ccaataacct tttttgataa aagttctact
    16861 ggagatatta tgagtagagt gacaaatgat gtcgataata tcagtacagg aatatcaaat
    16921 tcattagtac agttaattac aggaatctta aacatattga tgacttttat tatgatgttt
    16981 gtattaagcc caattttaac cttttgcagt gtaatattaa taccgatagt aatgtttgtg
    17041 agtaatttta ttgcaaagag aactagagtt ttttttaagc aacaacaagt tgagttggga
    17101 aaactaaatg cacatattga agaaatgata tcaaacataa atgtagtaaa atcttttaat
    17161 tatgaaagaa aatctgtaaa tgattttaaa gaagtcaatg atagacttct aaatatttcc
    17221 cttaaatcgc aaatttacac ttctctttta atgcctatta tgaatgtgat tagtaatata
    17281 ggatttgcaa ctatatgtat tataggaggc attcttgcat ctaaagatat tataaccata
    17341 ggggttatag ctagtttttt aagttatgta agacaattca caagaccttt aaatgaatta
    17401 gcaaatctat ttaatacatt actttcagcc atagctggat gtgaaagagt ttttgaaatt
    17461 atagatgaac aagaagagca agaagtgcat aacatgttta aaagtgagat taacgataat
    17521 aaagatggta atttaaactc tcattttgta aagggagaaa ttgagcttaa agatgtaagt
    17581 ttttcttatg attcaaaaaa gaaaatttta gataatataa acctaaaaat caaatctggc
    17641 acatcaaatg ccatcatagg agagacggga agtggaaaaa caactattat aaatctaatt
    17701 acaaattttt atcatataga tgaaggaagt atatttttag atggtaagga tatatactct
    17761 attaacagaa actatttgag aacttgtttt ggagtagttc cacaagaagg ttatatattc
    17821 aatgatacag ttatggaaaa tataaggtat ggaaatctgg aggctactga tgaagaagtt
    17881 atatatgcta gtaaaatagc aaatgcacat aaatttatag ttaaaatgcg tgaaggatat
    17941 agtactgtat tatcggatag gggtgaagat ttaagtgaag gtcaaaaaca attaataagt
    18001 attgctagag cagtattaaa aaatgctcca atacttattt tggatgaggc tacaagtaac
    18061 atagatatag caacagaagc taaaattcaa gaagcaataa ataatttaac ttatggaaag
    18121 acaagtataa ttatagctca tagattaagt accatatcaa attgtgataa tataatagtt
    18181 ttagaaaatg gtagaattgt ggaatcagga aatcataaag aattgataaa attaaaggga
    18241 cattattata gaaacatatt attgacacag ggaaaataag tatttagaaa aaacttttaa
    18301 aaaaattgtt taaaggtata tggtgcgggt atatatagac taacttaata aataaaaaat
    18361 ttaatttgat atataaaatt taggaggaaa gtaattatga agaaatttgt ttgtacagta
    18421 tgtggatata tacatgaagg agatgctgca ccagcacaat gtccagtatg taaagttgga
    18481 gctgataaat ttgaagaaat gaaaggcgaa aaaaattggg ctgatgagca cagaatagga
    18541 gtagctcaag gtgtagatga agaaataatc gaaggattaa gagctaactt tgttggtgag
    18601 tgtacagaag taggaatgta tttagcaatg agtagacaag ctgatagaga aggttatcca
    18661 gaagtaggag aagcttataa gagaatagct cttgaagaag ctgaacatgc tgctaaattt
    18721 gcagaacttc ttggagaagt tgtagttgca gatacaaaag aaaacttaag agttagagtt
    18781 gatgctgagt atggtgcaac tgatggaaaa ttaaaattag ctaagaaagc aaaagaatta
    18841 ggattagatg ctatacatga tacagtacat gaaatgtgta aagatgaagc tagacatggt
    18901 aaagcattct taggattatt aaatagatat tttggaaaat aaatttaata taaagtagat
    18961 tttaggagta tctcacttac aatttttaaa gttatgagtg agatattttt taattatttg
    19021 tactttattt tttatttcta acgattatat ttttaataat agagaataat ttaatagtaa
    19081 taatgcacaa cttttaaaaa taaatgatta atccaaaaat aaatttgatt ttagaaaagt
    19141 aaattgacat gtaaagaaga atatattaaa ctaagtataa aaaatttgct gttttgtaaa
    19201 ggtggtggat aatctgataa agtatataca taaaagttat gtagctattg ttgttttaca
    19261 tgaaatctat gggattaata gctttataga agatgtttgt caaaagtatt ataaatatgg
    19321 atatgatgta ttttgtcctg aacttctggg agaaaaaaga gtttttccat attcaaaagt
    19381 ccaagaggca tatgattttt ttataaataa tgttggtttt gatatttata aaaaagttga
    19441 aaagcttata aatgatttaa aatcagagta taaatatgta tttgttgctg ggtatagtgt
    19501 gggagcaact attgcatgga gatgcagtga agattctttt tgtgatggca taatttgttg
    19561 ttatggctct cggattcgag attacatgga tgtaattcca aaatgtccta ccttattagt
    19621 atttgcaaag cacgattcat ttgatgttga ttctatttct taccaacttt ctaggaaaca
    19681 aaatatccaa attgagattt tagatgcaaa tcatggtttt atagatagat attcaaataa
    19741 ttattctgat attcaaacaa aagtatttac tattaaagaa aaaagttttc tgtctaaata
    19801 tttagcatga tttagattat tataaaatat atagaaagat ttaattaatc tgaaaagttt
    19861 ttatgacact attgatattt aaaatattag tagtgttatt atattttttg aaataaaatt
    19921 aatcactaga attatagtgt tagttgtgct tttatgactt ataagaaact aatattagat
    19981 agtgtattta aatagataat aataaattca ttatagttga ataagaatat tatatgagaa
    20041 tattgcaatt tgatatattt accattacaa taaaagtagt tacaactaga aaaccaaata
    20101 agttaaagta agttggcaaa ttggaggttt ttaaatatga aagcatttaa aaagcacttc
    20161 ttgatacttt ctttgatatt tttacttatt atatcatgtt ttaacaatat actatgcttt
    20221 gctgatgagt ctgaaaattc aaaaaaaata agagttggat attgtgatga ctacggaata
    20281 atatcctcat caaaagagca ttcttataca ggatatggtt atgattatct aagagaaatc
    20341 tcaaaatata caagatggga atatgaattt gtaaaagggt cttgggaaga atgtttagac
    20401 agactagaaa aaggtgaaat agacttactt ggacctttac agaagaatga tgaaagaaat
    20461 aaactattta attttcctaa actaaattca ggatatgaat atagtgtact atatacaaaa
    20521 gatagtaaca ataatatgtt ttatgaagat ataagttcct ttaagggaat gagagtagct
    20581 gtacttagag gaaactttca taatattgca tttgagaagt atagagaaga aaataatttt
    20641 tcagttgaat atatctactg taattctatt gatgaattaa ttgagtctgt caatgaaaaa
    20701 aaggcagatg catttgtctg tggaagtatt ataaatgcta aaggaatgaa aatagttagc
    20761 aaattttcag tagagccttt ttattttgct actgcaaaat ataaacctaa tttggtaaaa
    20821 gaattagatt atgctttaaa agaattaaaa ataaatgata tgtattatga gttggaatta
    20881 tataaaaaat atttcaaaag agaggtcaat aattccatag catttactcg gcaagaaatg
    20941 aattttatta aagcaaaccc aaaacttact atggtatatg attcagagtg gtctcctgta
    21001 gagtattatg ataaggaaag caattcgttt aaaggtataa gttccaattt aatgtcaatt
    21061 atatcaaaaa aatgtggtat aaaatttgaa tatattaaaa caaaaaatta taatgagagt
    21121 cttgattaca taaaaagtgg taaggcaaat atgctatgtg gctcaatcaa tgaaaatgat
    21181 aaggcaaaac gatttaatat gaaattgaca aatccataca taaatattcc aatgattatg
    21241 gtaggaaaac tggataccaa tctcaataat gatttaaata ttgctttaac gagtagttat
    21301 aagtctatcg attcttatat agaaaaaagt tttgaaaatg ctaagacaac atcttataag
    21361 agtatagaaa gttgtctaaa cgctataaat gaaggtaaag caaacttaat gatacttagt
    21421 tcttatcagt ttgatgaact tttaagagaa ggaaagagtg agaatttatc tgttatatct
    21481 gttttagata caagctatgg gatgcgtata ggggtatcaa ataaaactga ccctatatta
    21541 gtatctattt taaataaatc aatagacaaa attactgaag aagaattaag tgattgtata
    21601 tattctaata ctattgacaa accttataaa gtaccatttg gtgtgatttt taaagaatat
    21661 tcaatacaaa ttatttcttt tgtatgtatt ttattcttaa ttgctattaa atatataatt
    21721 tataataaaa agaagaaaga ggattatcta aagaagatag catatacaga cccattgaca
    21781 ggagcagata gtatagataa atttaaaata aattcgaata aactgtttgc taaaaataat
    21841 ccagaagaat atgcattgtt ttatatagat gttgacaaat ttaaatatat aaatgatatg
    21901 tttggatatg atatgggaaa tgatactttg atacatatat caaatactat tgcaagtgaa
    21961 ttaaaggaag atgaaatttt tgcaagagtt tctgctgacc attttgttct tcttattaag
    22021 tataagacag atgatgatat taaaacaagg ttaaacaata tttacaataa ggttcaaata
    22081 cttagtaatc ctaaaataaa ctattataaa ttgattttag attgtggtat atataaaata
    22141 agtaaaagtg ataatgacat aaatactatt atggatagag ctaatactgc aagaaaaact
    22201 ataaaaggtg gtcataaaaa ttcatttgct ttttacgata aggaaatgca taaaaaaata
    22261 ttaaaagaga aagaaattga aaattcaatg gtagatgctc ttaataatgg agaatttatt
    22321 gtttattttc aacctaaata tagtctttca gattatcaaa ttataggggc agaggctctt
    22381 gttcgatggg ataatccaca aaaaggtcta ataccaccaa tagaatttat tcctgtattt
    22441 gagaggaatg gttttattgt aaatattgat ttctatgtat ttgaggaagt gtgtaaaaag
    22501 attagagaat ggatggatga aggacaaaaa gtagtaccta tatctgtaaa cttgtctcga
    22561 atgcattttg taaatagtaa ttttatagag aagtttaaat taattgtaga taaatacaaa
    22621 attccgacaa gacttataga attagagcta acagaaacag cagtattaga taatatagaa
    22681 gggttacttg atacaatgaa caatttgaaa gaaaagggat ttgtaatctc tatggatgat
    22741 tttggtacgg gatattcctc tcttaatctt ttaaaagaat tgcctgttga catattaaaa
    22801 ctagatagag cattttttac agaaaaagat gagagtaata atgaaaaaat tgttatatct
    22861 aatgtcatta aaatggcaaa ggaattgaaa atgaaagtaa tatcagaagg tgtagagact
    22921 atttcgcaag tagaatttct aaagcaaatt gggtgtgaca tggtacaagg atatttgttt
    22981 tctaagccaa tgcctgtaaa agagtttgaa aaaattgctt ttaaaaaaga ataaagcaat
    23041 gtgtaagtaa tgatatatat aataaaggtg ctttaatatt agttgagtat actattttag
    23101 agcatcttta tttttgtatt aatttttacg attttattaa taaaataaat caaatgagaa
    23161 aaaaatcaaa agaatacaat aatcacttgc aaaaaatata ctattgtgat agacttaaat
    23221 caaaattagg aattgtaaaa agaaggaaaa aataggatat tattttaata gattaagatt
    23281 taaggtattg taatttatat ataagataac gattgcttgt agatttaaat tagtttaaga
    23341 ggagggatat tatatgatgc cattgatact atcaaataca ggtgaagaag tagttataaa
    23401 gaaaatttca ggaagtgata agacgaggac ttttttaaat agtataggtt ttgtagtagg
    23461 tacaaatgtt aaaatagttt ctaagataga tggtaactta ataatagacg taaaagatac
    23521 tagagttgca ttagataaaa aaatggcaag tagaataata atatagggag gtaatgacat
    23581 gaacagactg aaggatatta agtgtggaga gactgtaaaa gtcaaaaagt tagaaggaga
    23641 aggagctaca cgaagacgta taatggatat ggggattaca agaggcgtta atatatttat
    23701 aagaaaagta gctcctcttg gtgacccaat tgaggtaaca gtcagagatt atgaactatc
    23761 aattcgtaag tcagatgcag aaaaaattat tgtggaataa taaagattaa ttagagtaga
    23821 gttaatgtaa ttatataatg agaatgattt tctatatcat gaatagtgat gtatttaaat
    23881 aataatggag ggaatggaaa tgtcaataaa aataggtctc ataggaaatc ctaactgtgg
    23941 taagacaaca atgttcaatg ggcttacagg ctcatcacaa tatgttggta actggccagg
    24001 agtaacagtt gaaaaaaaag gtggaaaatt aaaaggaaat aaagatgtgg aaatagtaga
    24061 tttaccaggt atttattctt tatctccata tacattagaa gaagtagtta cacgtaattt
    24121 tatgctagat gataagccgg atgcagtaat aaatattgta gatgcatcaa atatagagag
    24181 aaatttatat cttacaactc aagttttaga gctaggtata ccgaccgtta tagctcttaa
    24241 tatgatggat attgtaaata agaatggtga taagataaat attaaagaac tatctgaagt
    24301 tataggttgc ccagtggtag aagtaacagc agttaaaggt caaggaatta tggaggctgc
    24361 tgaaaaggca gttgaacttg caagtagtaa caataaatta aatttcaaat taccctttgt
    24421 tgatgaaagt aaggatgcaa tagaaaaaat tgaaaaaata atagaagaaa agactccata
    24481 tatagatgta gaaacacgct ggttagctat aaagctattt gagagagatg aaaatgttat
    24541 acaaaaactt gatatttcta aaacaatatt gaatagtatt gaagaaataa ctagaaattg
    24601 tgaagatgaa ttggatgatg atagtgaaag tataataaca gccaatcgtt atgaatttat
    24661 tagttcaata atttcaagta taataaagaa gaatcgaaaa ggtaaggaaa ctgtatcaga
    24721 taagatagat aagattgtaa caaatcgtat actagcatta cctatttttg cacttataat
    24781 gtggggagtt tactatatag cagtaagttc attgggtact atagcaactg attggacaaa
    24841 tgatgtactg tttggagaaa ttattcaagg caatgtaagt aattttctag cttctttaaa
    24901 tgtagcagag tggttacaag gacttgtagt tgatggtcta attggtggag ttggagcagt
    24961 actaggattt gtaccacaaa tcatgctttt attcttatta ttatcaatat tagaagattg
    25021 tgggtacatg tcacgtgtag cttttataat ggatagaatt ttccgtaagt ttggtctttc
    25081 aggaaaatca tttataccaa tgcttataag ttcaggttgt ggagttccag gagttatgtc
    25141 aactcgtact atagagaatg atagagatag aaaaatgact attatgttaa ctacattcat
    25201 tccatgtgga gctaagattc caataatagc attatttgca ggggcattat ttggaggtgc
    25261 ttcatgggta gctccatcaa tgtatttctt aggtattgca atgataatca tttgtggaat
    25321 tatattaaag aaaactagtt tatttgcagg agaaccatct ccatttgtta tggaattacc
    25381 tcaatatcat attccaagtg caaaaggtgt tttaatacat atgtgggata gaggaaaagc
    25441 atttataatc aaagcaggaa caattatatt tgttgcttgt ggagtaatct ggttcttaca
    25501 atcatttaat tggtcattac aaatggtaga tgctggagat agtatattag ctagcttagg
    25561 aaatatagtt gcaccaatat ttgctcctct tggatttgga aattggcaat catcagtagc
    25621 aacagttaca ggtctagtag ctaaggaaaa tgtagttgga acatttggag ttttatttgg
    25681 tatatcagat gcaacagagc aagacccaac acttcttgct tcagttgcaa gcatgtttac
    25741 agtagctagt gcgtttgcat ttatggcatt taatatgctt tgtgcacctt gttttgcagc
    25801 tattggagcc ataaaaagag aaatgggttc atggaaatgg acatggatta cattaggatt
    25861 ccaaacttta acagcgtata taattgctct tcttataaat caagttggaa gtttagtttt
    25921 aggtactgga ggaagtattg ctggggcaat aatatctata tttatagcag tagcagtagt
    25981 ctttgtagtt ttaacttatt caaataaaaa tatgaaaaaa gaaaaaatgg gtaaattaag
    26041 ttatatgaaa aattaattca tataaataag gagtgatgaa tatggctaca tttattatag
    26101 cagctattgt agtagtatta atggcactag ctgtaatgta tatggttaaa aattcaaaaa
    26161 agaatggtag cagttgtgga tgtggttgtt ctggatgctc aagtagtaag agttgtcata
    26221 gcgctaagag ataaatagga taagagcctg ataaaaagtt aaattgcttt attatcaggt
    26281 tcttattttt tgtataaata acaaatttca tatttgaagt aggttagact atgctgtaat
    26341 tttactgtat aattatatat aaatatatga ttaggaggga ttattgctaa attaagcaat
    26401 ataagtgaat attatgttta aatttgatgt tacaaacgag cttatgtgta tagcaagggg
    26461 aagtggtaaa ttttttgcaa aaaaaggtgc tatggtagcc tttaaaggaa attttaattt
    26521 tgaaaaattg ctgttaggtc caagtaatgg cggtggattg ggaagagcat tattaggtca
    26581 tgttcagagg tcattgacag gagaacaaat gccaataatg gtggttgaag gtgaaggtga
    26641 aatttaccta gctcaaaatg cttaccatgt agatgtaata tcaattgacc caggtgattc
    26701 catttatgtt gagagtgaaa acttattggc attttctgaa caattaaatt acagtgtaaa
    26761 attgattggt tcaggggtaa tatctcaaaa aggtcttttt actacacatt tagtaaataa
    26821 aacaggtcaa aatcaagatg ttgctataat aacagatggt aatcctctaa ttcttgaagg
    26881 accttgttgt gttgacccag atgcattagt agcttggact ggaagagaac catatcctaa
    26941 agtatcaaaa ctatcatgga agacttttat tggtcagact tcaggagaat cttatcatat
    27001 ggaatttgtt gaacctggac aaatagtcat tatacaacca tctgaaagat tgtctggctt
    27061 aaaaacagat tctacacctt ctgatagaat gagttcaggt ggattaagac ttggcataga
    27121 ttaaatctta tgatatagct taattattat ttaagatatt aaaaaataaa aagggtagca
    27181 gggatagata tgttaaaagg agttttatat gtttgagaaa attcataaaa ggcttaaagg
    27241 atattatatt tttttaataa ttttaatttt atggaagata gtatgtgttt tgggtatatg
    27301 gagtagctat attctgcctc ctcctgaaat agtcttagat acttttataa aaatgatata
    27361 tgacggttct attttcttaa atgtttatgc cagtgtaaga aggatattaa taggtttttt
    27421 aataagttca ttgatggcta taccacttgg agttttattt ggagtaaata aaaaaatgta
    27481 tgaatatttc aaaccactat ttgaatttat gcgaagtaca cctccactag ctttggtgcc
    27541 aatgcttatt ttatggtttg gtataggtga agaatctaaa attataatta ttattttggc
    27601 atcctttttt ccaatatttt taaatacatt gaaaggtata aaaaattgtg acaataaatt
    27661 aatagaagta ggtaaatctt ttaatttatc taaaaagaga attttttata aaataataat
    27721 ccctaattct atgctggata ttgttgttgg acttagttta gggcttgggt atagttttag
    27781 ggctataatt ggagcagagc ttattgcagc ttcttcagga ctaggatatt tgatttctga
    27841 tggaaaagat atgtctagaa ctgatgttgt attggtagga atttttgtta ttggattttt
    27901 aggtatactt tcagattatc tattttcaaa gataataaca aaatttagca aagggaagca
    27961 ggttgattta aatggttaga agtggatttt tgctagagaa tatatataag aaatatttag
    28021 ttgataataa agagcattta gttcttgata atatatcttt aaatatatct agtgaagaga
    28081 taactgttat attaggtgaa agtggatgtg ggaaaacaac gctacttaga attttagcag
    28141 ggcttgaaaa tgctactagt ggaaacatat atttttttaa taatgataaa aagtgtactc
    28201 caaaagtagg aatggtattt caagaaagta gacttatgcc atggctgaat gtaagtgaaa
    28261 atatactttt acatactgaa aaagataata gaaataaagt tgatttagac aagtatttaa
    28321 aaatgatgaa gcttgaaaag tttaaaaact catatccaaa tgaattatca ggaggaatgg
    28381 ctcacagagt aagtatagca agagcacttt ccttcaatcc cgatattttg ctgatggacg
    28441 aaccatttgc agcactagat tacttcacaa gaagaaaaat gcaaaaagaa gttgtaaata
    28501 tccataaaaa tactaaaaaa ggtgtagtat ttgtaactca caatattgaa gaagctatgg
    28561 aaatagcaaa gaaaataatt gtttttagta aaaataaaag gattaaacaa tttagtgtcg
    28621 aagatgaata taatagagat ttaactaaaa actattatat aaacttgaaa aaagaaatat
    28681 taagggaatt gggggagttt taattgatta aaagaaacaa aaagatttta gcagtaatga
    28741 catctttaat aatggtgttg gttgggactg taggatgttc aacaacaaat gataagaaag
    28801 atgaacctgc aaaaaaagag gctagtttac ctaaggaaat aaatttaact tatgtaaaat
    28861 caccacttaa tgttcctagt atattagaaa aaaaggatga tttatttgga aaggaattta
    28921 aaaaggacaa tataaaagtc aatttccatg aattgacaac aggaccagag caaactcaag
    28981 cattagcagc aggtgagcta gactttttac atgcattagg aggaacgtct gcaataatag
    29041 ctgcatcaaa tggtgttggt cttaaaatta cgaatattta tagccgttca ccaaaaggat
    29101 atatgcttat aactaataat gataatatta aatctataaa agacttaaaa ggtaaaaaaa
    29161 ttgtaggtcc aaaagggact atacttcatc aactgttgat tgctgcactt gctaaagaag
    29221 gctatactat agatgatgtt gaatatgtaa atatggatat tcctagtgct gcttctgcat
    29281 tagaaagtaa aagtgctgat gtagcaatgc ttgcaggtcc agtggcattg aaaacgataa
    29341 attcaggtgc caaaatgatt gtaaatggag aaggattagt aagtggaata atagttactg
    29401 ctgtaagtga tgactttgct gaaaaatatc ctgaattagt aaaaagattt atgaaggttc
    29461 atgaagaaac tttaaaatat atgaatgaaa acaaggatga agtgatggat gttgtatcta
    29521 aagaagttgg tttatcttta gatgaaacaa aagaaatgta ttcttggtat gactttagtt
    29581 ctaaaataac ggacaaggat ataaaagaat tagaagatac acaggaattt ttaatgtcta
    29641 atggaatgca acaaaagaaa ataaatatta aagatatgtt gtacaatcaa aattagaata
    29701 ctttaaaata ttaaagtgga aaatacaccc ttatttatta tggaaactat atggtaaaag
    29761 agggtgtatt tttattatta tacaaaaata caattaaaaa cagcttacta ttttatctac
    29821 acttatgtag tctagtaatt ttctcatttt cttacggtga agtaaaaact tcgaatatgt
    29881 gtcctcggat tgttttgtgt caccataaac tttccaatat ttaatcatag aaacttcata
    29941 attactatat cccataaatc caatcacatc tttaagagga tatcctaaaa aaatacctat
    30001 ttcatcagga aaaacatcac tcttaagttt atctactaaa tgctctaaat aagcattaac
    30061 attcgtattt tgtttgtatc ctaaaaactt taaaaagttt actgtttttt tacattttaa
    30121 tttttctgat aatgcttttt tatttacaaa taagattttt aatccctttt tttctttatc
    30181 aataactata aaatctattt tcttacattt atatagatat ttataaatat cattaatttt
    30241 ttcctctcta tttacatcag taaacgaaat atttattatt tcagcaggtt tagagcctaa
    30301 aaagactgga cctaaaactt ctaaaagcca ttttatatat gatgattcaa ttttattttt
    30361 acaacaaaat tgtgaattac aacaagacat aaaagataac ctccttcaaa tgaaaattaa
    30421 tatcaagtaa ttagattata ctatgaatga taatcaatat caataataaa attataattt
    30481 ttttatttaa ttatttattc attatgattt ccaaaaaaat aaattataac ttgtttaatt
    30541 ttagtaaata aaatataaaa atatagaaat actaaattaa gaaagaaaat tattaaaatt
    30601 ttttatagta taaaacatct aggagggtaa taaaaatgaa attaaaaaga actttatttg
    30661 taggattagc actagtatta gctataggta taactgcatg tactaaaaat aatgaaaaac
    30721 caagtgaaaa tacaggaaaa aatcctaatg aatctgtaaa taataatgaa ggatatatga
    30781 attattattc aacaagctat aatgattata tagcaggtct aaatagatat tctatttatg
    30841 atactccaga aagtataaat aatcagttta aagataaaga atatccagga aatgaaaaat
    30901 atctaagtga tgtaaaggct gcatataaag atagtagaga taaaatacaa tcatttgtaa
    30961 catctcttaa aaaagatggt aaaacagaag atacagagtt aaagaaaatg aatgatgacc
    31021 taatcgctga aggggaaaga ttagtaaaag acatagataa gagaatagaa aaattagata
    31081 aggtatctga tgaagatatg aaaaaaggtc aaaatgactt tataaaatta gttcatggaa
    31141 ctgaagatgt tggaaatgat ataggtagtg gttttagaaa aatgataaaa gatatgaatg
    31201 atagattagg aataacagga aataataaga aataatagaa taaatagttt tgaaatttga
    31261 aataaattat ttgagatata gcgaagcctt ataaataata cattttttgg cttcgctttt
    31321 ttgcatgtta ttaagatatt aatttttatc ttgtaacctt aatattttta ttataattta
    31381 tttagggatt attttcatac gtttttactt gttttttctc tttttaaatt tttgttttgc
    31441 aaaattgtaa gattctccta ttaaagtttt aaagttctca aatgtctttt cagtagggct
    31501 taggacgcat atccatccca tccatgagta gataggatgt ggcatgattg tgtccaattt
    31561 tgtaaaatca aaatccatat caactatttg acctacacct ggacgttttg gaatatatcc
    31621 aaacatttca ataaaagttt ctttttttaa tcctatattc acacggtata catttgggcg
    31681 actaaccaac gaacctttat catgattact gtctttttct ttaatggtaa gaacatatac
    31741 tcctcgcttt aaaataccat taggattgta gtaaattgct cgttcccccc aactattcat
    31801 taataaaaca tcatctaagt ttgatagaca ataattgata atatcatcag ccttaatagt
    31861 attattttcc ataaagtatc agtcccttct ttctttacta ttattattgc tttaaatgta
    31921 agaatatctt atcatataat agtgacaatt attgtcacta tatttaaatt aggagtataa
    31981 atatgtcaag agctgagcgt ttaattgaac tgatgataac aataaatgca aaaagaagtt
    32041 ttacagcagg agaattagca gaagaatttt ctgtatcaaa acgtactata ttaagagact
    32101 tacaggtgct ggagagtatt ggatttccat tatattcaaa agttggagcg gctggtggat
    32161 atcatgtact taaagagcgt atacttccac cgattgcatt ttcagaaagt gaggtaaaat
    32221 ctatattctt tgcatatcag tcactagaat attataatga tttgccattt gagcaagaaa
    32281 ctatttctgt tttaaaaaaa tttttaaatt gtataccaaa tgatattcaa tataatattg
    32341 agaatataag gcgtaaattt gttttttgga caccagatag gcactgttca acaccattat
    32401 tgaaagaatt gtttaatata gtaatgaatg aatctacaat taaaattgaa tattcatcaa
    32461 agcaaaaaaa tagtgtacgt accattgttc ctattggttt gtatgccatg aatggacttt
    32521 ggtattgtcc agcttactgt ataaaatcag catctattaa ggaatttcgt gtagacagaa
    32581 ttgtgaagat tttgagtata gaaaacttat caagtaagaa atataaggtt ttatcttcta
    32641 tacatgatta tcttaagaat atggaagtag gtacagatta tcatattaaa attaatttga
    32701 cagatgaggg agtaaaacgt tgtgaaacag aatttttgtt ggcaagaggg ttgaaaatct
    32761 tgtctaaagg tggatacata gatatgtata taccaaaatc tacacttaac tgggtggctg
    32821 aatatttttt aacttttggg aaaaatgcta caataataga acctatagaa cttaaacatt
    32881 tggtaaagtc taaagtacta gagctatata atcatcattg tatttaaatt attttattta
    32941 atagtaggat agagtttgga taaaatgtta attttcttaa tttactttac agatgattta
    33001 gatagattga tgttatttaa tttatttctt ataatgatgt tctatagtta tatagacatt
    33061 aaaatataaa gtgttaggag ctagaaaact aattaaaaat agttaattaa cgataataaa
    33121 aaataaaaaa tttaaataaa tttattgaca aatactatta atgaatatat catatataac
    33181 atagcaacaa atgataatag aattaaatta aataacgtct tatcaagagt ggtggaggga
    33241 ctggcccttt gaaacccggc aaccagtata ttttatatac attggtgcta aatcctgcaa
    33301 ctaatatagt tgatagatga gtataaatag ctttctaagc ctgagtttat actcgggctt
    33361 ttattttgtt gtaatacata agagaggata aacataaaaa ctgagcagaa tatatgggag
    33421 gaaattttat gattagcata aaaaatgtta ataagtatta tggaaagatt caagtgctta
    33481 aagatgtaag tattgaaata gaatctggag aaatttttgg aataataggt catagtggtg
    33541 cagggaaatc aacactactg agatgtataa acggattaga agaataccaa gaaggcagtg
    33601 tacttgtttc tgataaagaa gtaaagtcat tgaatgaaaa gcaaatgaga gatttaagaa
    33661 aagagttagg aatgattttt caacactttt cattgcttga aagaaaaact gtatttgata
    33721 atgtagcatt gccattagaa tgttttggat actcaaaggc agaaattaaa aaaagagttt
    33781 tagagttatt agaagtagtt ggaatatctg aaaagaaaaa tgataaaccc agaaatctaa
    33841 gtggcggaca aaaacaaagg gttgcaattg ctagagcttt agcactaaat ccacaagtac
    33901 ttctttgtga tgaagcaact tcagcattag acccaaatac tacaaagtca attctttcat
    33961 tgcttgaaga tataaataaa aatttgggaa taacaataat agttgtaact catcaaatgg
    34021 aagttataaa gcagatttgt ggaagagtag caataatgga aaatggagaa gtattagagg
    34081 taggagatac agaagaaata ttcttaagaa atactaaagg acttagaaaa ttaataggtg
    34141 aagaaagtat aatattgcca aaaggaacaa atataaagat actattccct aaagatattt
    34201 ctaatgaagc tattattacg actatggcaa gagaactaaa tatagatgtg tctataatat
    34261 ttgggaaatt agaacaattt aaagatgata ttttaggttc acttattata aacatttcag
    34321 ataaaagtgg agagcaagta aaacaatatc taactagtaa gggcataaga tgggaggaaa
    34381 tgataaatga atagtttaat tgacttttta acaacactat ttccaaatgc attgttacaa
    34441 actttgtata tggttatagt accaactata gtggcaacaa tattaggatt tatattagca
    34501 atcatattag tagttacaaa accagatgga ttaaaaccaa atagcacaat aaatagtgca
    34561 ttaggattta tagtaaatat atttagaagt ttcccattta tgatacttat agttgcaatg
    34621 attccaataa ctagattaat cgttggaaca agtatagggg aaactgctgc aatagtgcca
    34681 ataactattg gggcagcacc gtttatcgct agaattatag aaagctcatt aaatgaagtt
    34741 gataaaggat tgatagaagc agcaaaatct tttggagcta caaaaagaca aatagtattt
    34801 aaagttatga taaaggaagc tatgccttca atagtatctg gaattacatt atcaataata
    34861 tctatacttg gttatacagc tatggcaggt gcagtaggag ctggaggatt aggtaatata
    34921 gcacttattt atggatatca aagatttgat acagcagtaa tggtatatac tgtaatagca
    34981 cttataatat tagttcagat aatccaggga gtaggaaatc tggcttataa gaaactaaaa
    35041 taaattaatt ataaacattt taaagagggg gagtaaaaat gaaattaaag aaattattat
    35101 cagtagcatt ggtgtcagca atagcaatat cagcagtagg ttgttcaaac aaagaggata
    35161 aaaaaatact agtaggagct tcatcaaatc cacatgcaaa gatattggaa gttgcaaaac
    35221 ctttgttaaa agaaaaagga tatgatttag aagtaaaaat atttgatgat tatgtacttc
    35281 caaatacagc tttagatgaa gggtctttgg atgctaactt ctttcaacat attccatttt
    35341 tagaggaaac tgtgaaggag aaaggatata aacttactta tacatctaaa gttcatatag
    35401 agccaatggg attctattca gaaaaagtta agtcattaga tgaattaaaa gatggagctg
    35461 ttatagctgt gccaaatgat gcaactaatg gagctagagc acttaaatta ttagcaaaaa
    35521 ataaattgat agaagtaaaa gatggagagc ttataactaa aaaagatata actaaaaatc
    35581 ctaaaaatat agtaataaaa gaaatgaatg cagagcaatt accaacagta ttaaaagatg
    35641 ttgacggagc agtaataaat tctaattatg ctttaacagc taacttaaat cctactaagg
    35701 atgcaatagt aatagaatca agtgattctc catatgtaaa tataatagct tgtagagaaa
    35761 ataataaaga tagtgataag attaaggctt tatcagaggc tatgaatagt aaagaagtta
    35821 aaaaatttat acaagatgaa tataaaggaa gtatagttcc agctttttaa actgaatata
    35881 caaaatctac aaaatgagta aaattaaaaa tatttactca ttttttttta taactagaaa
    35941 gtgacaaatt ttttggaaga attgtggtaa catatttata ggtaaaacta tataaaaatg
    36001 aagaagtggt ggggaatatg gaatctaaag gaactttaag taagaataag gtctatatac
    36061 tagctaatgg gttatttttg gttattgcac ttttaaatat aaatttgtat acagtttcta
    36121 taaatatgta tagaataatt ttactttgga tatttggata ttctatagtt tatataagta
    36181 gctttaaaac agatgaattt ataaatatat tgaaagtagg gtgtcttgta ttagtttttg
    36241 taagtatttt aggagtagta aatttaaaaa ttcaaaaatt ccaaattgta ttgcttaact
    36301 taagcataat taatatgtct acttttatat acttaaccat ttctaaagta aaaaaactaa
    36361 gaataagccc aatactaatt ttttatagtg cttttgtgat attagattac tttataagaa
    36421 atatttttag tgatattaac tggaatatga ttattatatt aattaatgtt tgtatatcta
    36481 tgtttaattt actatatttg ttgaataaac ttgatagtaa cattgagcac tataagttaa
    36541 taaaagattt aacatatttt gtttttttta caactattat atgttttgta gcaatttcta
    36601 agattaatat agtagattca gatagattaa taggagtaat atatttacta ttatgtaacc
    36661 atacttatta tgtatatgta tacagtctta ataatagagt agtgtatcca tattatgaac
    36721 ttgattcaat caataaaaaa ttaagtaaaa agtcagagca attaggaaag ataaatttag
    36781 caatagaaaa ggatatgatt atacaaagaa cattaaaaaa ctacatagac cagagaaaag
    36841 aattacttag acaagctctg gatacaatac caaatgtatg gatagtaaca gactatgatt
    36901 ttaatataag ttacacaaat aataaattta aagatgaatt ttcaaaggat atgaataatt
    36961 attataaaat attaactttt ataaaggaag atgaaaaagt tgctgaaaaa ttgaagaaat
    37021 ttgataacga tataagtata attgataaac tggtagagtt aaatgataaa atttatttgt
    37081 taagtttaag taataataaa gatgaaagca attacttaat aagtttaaat gatattacaa
    37141 atgaaatcaa aatagatgaa gaaataagaa atataaataa agactatgaa aacattatac
    37201 taaatattcc atctcctata cttgtaagaa gtgctgaagg tggcataaag aagaataagg
    37261 taataagtat aaataaaaaa tatgaaaaga gttttaaatg tgtttcaagt gatttagtcg
    37321 atatgacatt agaacaatat tttgaaactt ttaacataga tttctttgac aatagggaat
    37381 ttaaaagatt aaatctaaca caagaaaaga aagctgaaat agtaagttac aatgacacag
    37441 caaactgtat agttaatttt gtgatgtctg actcagaagg tgaagagcat gttgaagaag
    37501 ttagagttgg agactattgg tcagataata aactctttaa attgcttaca tttagagata
    37561 taactaaaga gataaatatt cttagaacag taaatgaaca aaaaataata tatgaaaaat
    37621 tactggatgt tataccagag gctatttttc ttgaggattt aagtacatca agagtactat
    37681 atacaaatag agcctttaga gagttgttcg gaatttctag tgatgtatta ggagttacaa
    37741 cacaaaaata tagaaatata ttagtaaaaa aatacataaa caatttaaat ataggagaaa
    37801 gagagaagag tatccatata gtaaatgaaa ataatcacat taaagaagta aaaatgatat
    37861 caagaacatt atactttgga cagaaaagaa gtagagtgag aattattaaa gatttaagtg
    37921 tgcaaagaga gtctgaaaga cttaaaaaag cattaataaa acaaagacag tatgaccaaa
    37981 tgaagatgga gttttatgct aatatatctc atgaacttaa gacaccttta aataatatat
    38041 atagttcagt tcaacttatt gaaaaccttt ataaaaaagg aaaaataatt gattttcagg
    38101 atatactaaa agaacatata aaaataacta aacaaaatat gtttagatta ttgagattaa
    38161 tagataatat aataaatatt tctcaagtta agtcagacat atataagatt aaagcagtta
    38221 attttgatat tattgacata acagaaagaa tagttacatc tattagtagt tatgctaagt
    38281 ctaaaggaat agatttaatt tttgatacag atgaagaaac tgttatggta gggcttgacc
    38341 cagaatcgat agaaagaata atactaaata tattatcaaa tgctataaaa tttactttag
    38401 aaggaggaga aatccttgta ggtatatata aaaaagacga aacagtagag ataattataa
    38461 aagatactgg agtgggcata gacaaagaaa aattaaatga tatatttaat cgatttaaac
    38521 aaattgaaaa cagtggtata tcaaatgaat ttggaagtgg tataggttta tgccttacaa
    38581 aatcattgat tgaaattcaa aatgggaaga tttacataga tagtaaggta ggagaaggaa
    38641 ctaatgtaaa agttatattc ccaattaaag aggttgttga agaagtatat gataattcaa
    38701 attacaatga taatattgaa aagtttgaga tagaattttt tgatatatat aaataataaa
    38761 tgtctaaatt tattgtttat atatatcaca ttaataagag ttaattttat ttattacttt
    38821 agttgtattt gatgcgtttt aaataaattt tatgaggtga aattttggaa aaggattttt
    38881 ttagaaaaaa tggaattgat ttagccaaat caatattagg taaatatcta ataaggaaat
    38941 atgaaaataa agtaattgtt accaaaatca tagagacaga agcatacatg ggtgtaaatg
    39001 ataaaggagc acatgtatat ggcaataaaa agacagatag aactaagcca ttatatttag
    39061 atggtggaca tatatatgtt tatttaattt atggtatgta taattgcttg aatttatctg
    39121 caaatataga aaatgtgcca gagtgtgtat taataagagg ggtagagcct ataacttctt
    39181 tagatgagat atctatgaat agatacaaca aagcttacac tgagttgagt aaatatcaag
    39241 taaaaaatat tactaacgga ccaggaaaac tttgcaaagc tttaaaaata gatagaagtc
    39301 taaatagtaa gagtataatg ggtgaagaat tatatataag tgatttttat tatgatgata
    39361 aaggaaaaaa agtatttagt aaagatgagt tagatataaa aactagtaaa cgtataaata
    39421 tagattatgc agaagaagca aaagattttt tatggcgttt ttatatagaa taagttttta
    39481 tataggtaag atatgtatct ataggaaggt attttatagg tatgtatctt atttttttat
    39541 agaattttta gtttgataaa aataacttta tagaattaca aacatattta ataaatttat
    39601 aattattttc atgatataaa gaaagatata ttttggcgaa atgagctata aaaattaatt
    39661 tttttgtgta ttttattaaa aattataaaa tttgtataga taat
//
LOCUS       DAEPID010000033        39189 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.033, whole genome shotgun sequence.
ACCESSION   DAEPID010000033 DAEPID010000000
VERSION     DAEPID010000033.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 39189)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 39189)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..39189
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.033"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            <1..770
                     /locus_tag="KR257_001883"
     CDS             <1..770
                     /locus_tag="KR257_001883"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861222.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=3
                     /transl_table=11
                     /product="DUF1648 domain-containing protein"
                     /protein_id="HBH0030587.1"
                     /translation="LKSEIYSKLGHIDIDSKLIVDMDFINKKNKIIKKFKIIYLIPIL
                     FTLGMSIFIAFNYNQLPDSIATHWNINGSPDVFIDKSFLNVFKLIGTDFCLMVLLYIT
                     SIGSIKSRIKIDTNRIEESRVENIKYLNKIGYLFLILMIIMTTQFFTTLLSIKTKLST
                     AMNITTLLVIIYLIATYINSPNLKFNSSYSPEEDEKYWIAGIMYNNPNDPSLMVNKRF
                     GIGWTINFGNPLGKILYIAIALLLIFSLFSLIKSLLL"
     gene            890..1366
                     /locus_tag="KR257_001884"
     CDS             890..1366
                     /locus_tag="KR257_001884"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896384.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HD domain-containing protein"
                     /protein_id="HBH0030588.1"
                     /translation="MLSKAEIKYFNECASEILSSEKVQLMRTFPHHGNVSCLEHSLSV
                     AYYSYLLCKKLHLSVDIQSVIRGALLHDFFLYDWHYKGDRKGLHGFTHPREALKNATL
                     FFQINEKETDIILKHMWPLTVKPPRYKEAFIVCLLDKFCCLVETLKIHSLLSPYHV"
     gene            1752..2219
                     /locus_tag="KR257_001885"
     CDS             1752..2219
                     /locus_tag="KR257_001885"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429434.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pyridoxamine 5'-phosphate oxidase family
                     protein"
                     /protein_id="HBH0030589.1"
                     /translation="MFKEMRLKKREMTKEDTVEVLKNGEFGTFSTISENGYPYGVAVN
                     YVYFNDSIYFHCARNGHKLDNISKNNKVSFLVVANESVIPDKFSTTYSSAIVFGKACT
                     VENEEKKNALVEIIKKYSKGFFEEGMKYIEKDMNLTTVVKIEIDHISGKASRL"
     gene            complement(2279..2851)
                     /locus_tag="KR257_001886"
     CDS             complement(2279..2851)
                     /locus_tag="KR257_001886"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896380.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NAD(P)H-dependent oxidoreductase"
                     /protein_id="HBH0030590.1"
                     /translation="MKVAVIFHSVCGSTYLLAREYKEALEEMNIEVDIFRVSDEVAKT
                     LPQYYLINSKEYKDEFESINVIKSGKEILDYDAIFMGSPTYYGNVSGPMKMFMDSFSD
                     IWVGTPLSGKIFGCFATAGSQHGGGELALQAMNIFAQHMGMTLLSVPCSVRGGYPAYG
                     ILHIAGDNSDIRPNDDAKIGIRDYLKRLNI"
     gene            complement(2914..4011)
                     /locus_tag="KR257_001887"
     CDS             complement(2914..4011)
                     /locus_tag="KR257_001887"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896378.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Nif3-like dinuclear metal center hexameric
                     protein"
                     /protein_id="HBH0030591.1"
                     /translation="MLLKSLTRKIEKKYPLNLAEDWDNVGLIVGDFDMDVKKVLVSLE
                     ANEDVIDEAISKNIDLIVTHHPFIFGKINKINSGDLKGRLIQKLIKNDISLYSMHTNF
                     DIAFDGLNDYFMEIMEFGNSKVLDITKSENLYKLAVYVPHNYSDELRKVLSNSGAGHI
                     GNYSDCTFSIEGEGQFKPLEGSNPFLGSVNDIETVNEVKIETVVPQKLLGGVISSMLD
                     AHPYEEVAYDLYKLENKGEIFGLGRISKLDKSMTLESLSRKIKEKLNMKHIRVVGNLS
                     TDITKVAVVTGAGSEFVKKAKRQGAEVLITGDVKYHEAQDALDIGMCIVDCGHFDTED
                     IFKNVMKRFLDEFSKIEVIKSNVYLNPFSTI"
     gene            complement(4025..4714)
                     /locus_tag="KR257_001888"
     CDS             complement(4025..4714)
                     /locus_tag="KR257_001888"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419893.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SAM-dependent methyltransferase"
                     /protein_id="HBH0030592.1"
                     /translation="MKLTDRLLKIASLVSDGKKIADIGTDHGYIPVYLLKEGKVPFAV
                     LADVNKGPLDNAHKEVIQNNLLDKVDLRLGSGIEILEIGEVEEVIIAGMGGILISELL
                     EAKKEVAHNVEKLILQPMQAQEELRYYLLNNGYEILEEVLVREDFRIYEIIVAKYTGK
                     NTIIEDEIYYEVGIKLLENKDSLFNDFIEKKIKTYSSIVNKLEGKNGEAIDKKRKESE
                     VAIKKLENLIK"
     gene            complement(4879..6045)
                     /gene="rpoD"
                     /locus_tag="KR257_001889"
     CDS             complement(4879..6045)
                     /gene="rpoD"
                     /locus_tag="KR257_001889"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429425.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RNA polymerase sigma factor RpoD"
                     /protein_id="HBH0030593.1"
                     /translation="MENKSNKKELKKVTAKTLIEKGKKQGSLTLAEIMEAFSETELDK
                     DQVENLYETLGNLGIEITETKNYKADIDFSVADDDLSIGHLDEDAEAISHDDSSAIEI
                     ETVDLSLPKGISIDDPVRMYLKEIGKIPLLKPHEEVEFARRMHEGDEIAKQRLVEANL
                     RLVVSIAKRYVGRGMLFLDLIQEGNLGLIKAVEKFDYTKGYKFSTYATWWIRQAITRA
                     IADQARTIRIPVHMVETINKLIRVSRQLLQELGRDPKPEEIAKEMEMTEDKVREIMKI
                     AQDPVSLETPIGEEEDSHLGDFIPDDDAPAPAEAAAYSLLKEQIEDVLGSLNDREQKV
                     LKLRFGLEDGRARTLEEVGKEFDVTRERIRQIEAKALRKLRHPSRSKKLRDYLD"
     gene            complement(6063..7853)
                     /locus_tag="KR257_001890"
     CDS             complement(6063..7853)
                     /locus_tag="KR257_001890"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893065.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA primase"
                     /protein_id="HBH0030594.1"
                     /translation="MNDIKDIIEEIKARCDIASIISEYMNIKQSGANYKGLCPFHGEK
                     TPSFYINTSKQIYKCFGCGEGGDVINFVMKMENLDFMDAVKILANKCGIEINTNMNEE
                     TRIKIEKSKKFQDIHTEAARFYLSNLLGSKNLGYEYLRIRGLDDKIIKKFGLGFSLDS
                     WNSLMNTLISKGYKKQDLLECGLIAKNRDGTNCYDKFRNRVMFPIFDYRGNIIGFGGR
                     VLDDSLPKYLNSPDTLIFNKKQNLYGLNFARKNLESKTIVLVEGYMDLISLYQYGIKN
                     VVATLGTALTEQQGILIKRYADTAIISYDSDEAGIKATLRAIDILTKLGINVKVLDLK
                     DAKDPDEFVRKYGLSDYKKAMDVSTHYIKYKIDHLKKEFNIQKDEERVKFAKEASKII
                     KQLTSPVEIDFYTKYLSNQIDINVESIKREVYGKNYNKPYNNKNQKKIEEKVIEKVEV
                     RQDGKQLVEETLIKIMLEDKKIREIALLKVEESDFLLKESKEILNYMIKNQELDKITI
                     DKLKSLNISEEYLKELNSISLNSINLENTKEIEGIITNIRKNSLEEQINSLLREQQEL
                     ENNNDMKEVDGRVMEIALKIVEINKILKSL"
     gene            complement(8108..8893)
                     /gene="aroF"
                     /locus_tag="KR257_001891"
     CDS             complement(8108..8893)
                     /gene="aroF"
                     /locus_tag="KR257_001891"
                     /EC_number="2.5.1.54"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419887.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="3-deoxy-7-phosphoheptulonate synthase"
                     /protein_id="HBH0030595.1"
                     /translation="MKENLFNNNSKIEINTNNKKITVKKDKLIIAGPCAIESYEQLLE
                     TAKFVKSQGANILRGGAYKPRTSPNSFQGLKKEGLEILKAVKDEVGMAVITELMDVRD
                     MDELYSISDIIQIGSRNMQNFTLLSEVGKQNKPVMLKRGIASTITEWIGASEYIAIEG
                     NSNIIMCERGIRTYNDYTRNTLDLAAVPIIQKETGLPVVVDPSHATGVRYLVKPMSLA
                     SFACGADGIMVEVHPDPENALSDGAQSLCFNEFEDLMKSINNY"
     gene            complement(8874..9380)
                     /gene="folK"
                     /locus_tag="KR257_001892"
     CDS             complement(8874..9380)
                     /gene="folK"
                     /locus_tag="KR257_001892"
                     /EC_number="2.7.6.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889259.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="2-amino-4-hydroxy-6-
                     hydroxymethyldihydropteridine diphosphokinase"
                     /protein_id="HBH0030596.1"
                     /translation="MNKAYLGIGTNMGDRFDNLSRACELLKNSDSIYKVKESSLYETK
                     PWGYTEQADFLNMCVEIETEFEPYELLEYCQEIERELHRERIVHWGPRTIDVDVLFFN
                     DVVSTDERLTIPHPRIQDRAFVLIPLMDLNEELIINEKTIKEHLNLLSAEEREEVKEL
                     VGYERKPI"
     gene            complement(9373..9738)
                     /gene="folB"
                     /locus_tag="KR257_001893"
     CDS             complement(9373..9738)
                     /gene="folB"
                     /locus_tag="KR257_001893"
                     /EC_number="4.1.2.25"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889257.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dihydroneopterin aldolase"
                     /protein_id="HBH0030597.1"
                     /translation="MDKILLSNLGFYGYHGVLKEENFLGQKFFVDMELYIDSREAGLS
                     DDINKSVSYAEVYNVVKDITENKQFNLLEALAENIAEEVLNKFILINGVMVRVRKPEA
                     PVNGIYDYFGVEIRRTRDE"
     gene            complement(9749..10540)
                     /gene="folP"
                     /locus_tag="KR257_001894"
     CDS             complement(9749..10540)
                     /gene="folP"
                     /locus_tag="KR257_001894"
                     /EC_number="2.5.1.15"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893060.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dihydropteroate synthase"
                     /protein_id="HBH0030598.1"
                     /translation="MFDYGKRTYIMGILNVTPDSFSDGGDFNNLDIAIQHAKDMVDQG
                     ADIIDLGGESTRPGHSYVDSDEELRRVIPVIKKLKQELDIPISIDTYKADVAEEALKL
                     GVTMVNDVWGLRKDKNMASVIGKYDAEVCIMHNQDGTNYDKDIMESIKDFFKVSIEMA
                     MSCGVKKEKIVLDPGVGFGKDFEQNIEVLRRLNELKDLGYPILLGTSRKSVIGKVLPV
                     EPKKRLEGTIATTVLGIRDGVDIVRVHDVYENLMAARMTDAIYRK"
     gene            complement(10604..11176)
                     /gene="folE"
                     /locus_tag="KR257_001895"
     CDS             complement(10604..11176)
                     /gene="folE"
                     /locus_tag="KR257_001895"
                     /EC_number="3.5.4.16"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419881.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GTP cyclohydrolase I FolE"
                     /protein_id="HBH0030599.1"
                     /translation="MNKVDKEKIQHAVREILEAIGEDPDREGLIETPNRVARMYEEIF
                     SGLSEEPRDHLKVLFADEKHEELVLVKDIPFYSCCEHHLVPFFGKAHIAYLPKGGRLT
                     GLSKLARVIDTLAKRPQLQERITKNAADIIMEELQPYGVLVVVEAEHMCMTMRGVKKP
                     GSKTVTSAVRGIFEKDIASRAEAMSLITMK"
     gene            complement(11202..11903)
                     /locus_tag="KR257_001896"
     CDS             complement(11202..11903)
                     /locus_tag="KR257_001896"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728681.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0030600.1"
                     /translation="MIGCIYEVYNEEMTKIIENQNTLAVYLVGSSKDVDFTLYDVVIN
                     DIDVFVFVKEGEKQERILFKKKGIEFDVNYFSKDGVKKLLSNREYFFVKEMKDAKVLF
                     DRENISHIIKDISRDIYLEGPSKMSLEEKSFIKQDIGAKILNLKNKEKFDVFEYHFLT
                     NLYLKDIIIGYFNINDKWVPKDKKLLKVLKKENNELFELVSKVSENYDYQRLLDVYNY
                     IFKEIETKEVIKLIF"
     gene            complement(11937..12680)
                     /locus_tag="KR257_001897"
     CDS             complement(11937..12680)
                     /locus_tag="KR257_001897"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728682.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aminotransferase class IV"
                     /protein_id="HBH0030601.1"
                     /translation="MKNNVGFDSSLSKFGIGLFETIRVKNGIAVDLDIHIERMLSSIN
                     CLDLDINYKKDFLINEIVTYIKKENVINKALRITVFDEGYNISIRDIPYNQETYEKGF
                     KLAISPIVRGNSLIHRHKTTNYFENIYTKNIANKTGYNDGIFLNSEGVILECSMSNIF
                     FIKGERVYTPSDRLPILNGIIKKRIIEICDELHIELIENEINISEISSFDFVFVTNSL
                     MGAIKVTEIDKIKFNKENVVFDKIVKLLE"
     gene            complement(12670..14019)
                     /gene="pabB"
                     /locus_tag="KR257_001898"
     CDS             complement(12670..14019)
                     /gene="pabB"
                     /locus_tag="KR257_001898"
                     /EC_number="2.6.1.85"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889251.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aminodeoxychorismate synthase component I"
                     /protein_id="HBH0030602.1"
                     /translation="MIREINTKLNSFEIFTIFRNEHDSFILDSAMDKEKLGRYSFISS
                     QPFKVLKYKDTDENPLEVLKEELHKYRVVNDTNLPFVGGAVGYLSYDLGNYIENLPRT
                     AVDDIEMPDMYFGFYNHVIVIDHLVQKTYIATPNIDIELEEKIIDDIEQRILKEEKKG
                     IDSICYEEKEVTPIRLKSNFTKEEFKNAVQSVREYIRQGDIYQANLTQRFSGETELTS
                     FELYRDLRRFSPAPFGAFLNFEDAHILSNSPERFIRCVNKRIETRPIKGTRPRGKDKE
                     EDLRLQQELRNSEKDRAELLMIVDLERNDIGRISKTGSVKVPELFVIEPYANVNHLVS
                     TVVGELKDDKDATDVIKATFPGGSITGAPKIRAMEIIDELEPTQRNVYTGSIGYIGFN
                     GDMDFNIAIRTIIKNDKKVYFQVGGGMTWDSDPDEEYQETLDKAKSIMKALRGYYEE"
     gene            complement(14021..14605)
                     /locus_tag="KR257_001899"
     CDS             complement(14021..14605)
                     /locus_tag="KR257_001899"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419873.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aminodeoxychorismate/anthranilate synthase
                     component II"
                     /protein_id="HBH0030603.1"
                     /translation="MILMIDNYDSFVYNLVQYIEELGEAVVVKRNNEIKISDIEELNP
                     EVIVLSPGPCSPKEAGICIDIVEHFKGKKPILGICLGHQTIGHVFGGDIIKAQQPVHG
                     KVYSINHTNKGVFRGLKNPLNVTRYHSLIVDSNTVPKELEITAITDKGEIMGIRHKKY
                     LIEGVQFHPEAILSEYGHEMLKNFITEARERVHM"
     gene            complement(14629..15348)
                     /locus_tag="KR257_001900"
     CDS             complement(14629..15348)
                     /locus_tag="KR257_001900"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419871.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="polysaccharide deacetylase family protein"
                     /protein_id="HBH0030604.1"
                     /translation="MTSWKKKTVYKCLIAVALFCGIVLISNFSKVSALMMDTNGNVLI
                     KHGSREKKLIAITFDDGPHPKETSQVLDVLKKYNVKATFFIAGKHAKWYKEPLVRASK
                     EGHEIGNHTFNHPDISNLSSSQIEEEIVKCEDILKEVTGKKPTLFRPPFGSYREKDLI
                     EIAKKHDYKVVLWTGVDVKDWKNPGANSIADKIINKVQNGDIILLHDYATNDTVEALD
                     MFIPKMIEKGFKFVTVSELIK"
     gene            complement(15376..16440)
                     /locus_tag="KR257_001901"
     CDS             complement(15376..16440)
                     /locus_tag="KR257_001901"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728685.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptidase"
                     /protein_id="HBH0030605.1"
                     /translation="MKRLIALVLVVLIVLFYSPELLKEGYDLKEKFFQSEIWNEFLDK
                     ININDNSKKDKKEKSQNLQSNNTEGENLGESDIKNFEKISLGDNLSYVLSSIGKPGRI
                     DISEYGFDWYVYNQYGKEFAMVGLENDEVVALYSNSINSCENQDIKLNQDRQTVRTKI
                     TPLKYKRKGNTRYIINSENQYDIISKEGKYITIFYDIHEENRVCSYLIIDKSTEDEFK
                     NLYPDDSEELKKCFELEVIDLVNSVRNQRGLNSLRYSEQATLSSRKHSEDMRDNNFFD
                     HVNKKNETPFDRMKREGIVYTSAGENIAAGQINAIYAHEAWMNSEGHRKNILGNYNNI
                     GVGVIFGGSYKTYYTQNFYK"
     gene            complement(16584..17393)
                     /locus_tag="KR257_001902"
     CDS             complement(16584..17393)
                     /locus_tag="KR257_001902"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889246.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0030606.1"
                     /translation="MNLSKEYVNLYDNYLKYINEVNKEIRSIKNMKKRVLKRGDFAPE
                     NEVLELEGKTIRDIDDVDTKKPKNKIYKFSNGDVYVGKFLEGKMEGKGSYTFFVDEGT
                     VMEYIGEFKEDKKNGKGNFIFSNGNEYIGYFEEDMMSGIGNMLYSSKDEYIGTWKNGK
                     KDGKGIYKWSDGCIYAGEFKGGKMEGYGICYNSKGEVLYEGEWKNNLIHGKGTYIWEK
                     GKKYIGEFMHGKKHGQGTFYLNNELVYEGTWKFDKPSIFDRTLDEIFSLRL"
     gene            complement(17635..18501)
                     /locus_tag="KR257_001903"
     CDS             complement(17635..18501)
                     /locus_tag="KR257_001903"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429405.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YitT family protein"
                     /protein_id="HBH0030607.1"
                     /translation="MSEVKNTLQKHPVLRYSTMLFGMLMTSIGINGFLRPAHLLSGGA
                     TGIATSINYLTNINVGLLTFLINIPIFILGFIYLEKEFCISSLVNMIVFSLLLGATQE
                     ISNIIPIHDILLQSVYGGILSGLGVGVVFRTRSSQGGTDIIAAILKIKKNIEMKDTAL
                     AINGLIVLTGSFLFGLDLALYTLIGLFLNAYSMSFIKDAMNYQKSVMVMSNEVDLIAE
                     DIMKSLVRGVTFLDAEGAYTHQKKKIIYTIVSSNEIPKIKDIALKYDKKAFISVNDVT
                     EVKGRGFKAKDL"
     gene            complement(19021..19710)
                     /locus_tag="KR257_001904"
     CDS             complement(19021..19710)
                     /locus_tag="KR257_001904"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438619.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LrgB family protein"
                     /protein_id="HBH0030608.1"
                     /translation="MYNVLQTPVFGIIVTIVFFNLGRYIQRKTSNPICNPLLIAIVGI
                     ILFLSISKIPYENYKIGADSLNFFLGPVTVVLAVPLYKQFELFKKHMFEIIVGIGCGI
                     VISFVSVLIIGKIANSDVSIINSLIPKSITTPMGISLANSLNGVESITVVAIIFTGIF
                     GGMVASTVFKLGNINHPVAKGIALGTSAHALGTTKAFELGEIEGAMSGVSIGVSGTIT
                     VILIPIIMNFI"
     gene            complement(19703..20074)
                     /locus_tag="KR257_001905"
     CDS             complement(19703..20074)
                     /locus_tag="KR257_001905"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419862.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CidA/LrgA family protein"
                     /protein_id="HBH0030609.1"
                     /translation="MKVFNQLVIILSIWVIGEYISSFIQGIILIPGSIVGMLLLFLLL
                     QFKVLDLSSIENVSGFFLDNMAIFFIPAGVSLIKSLDLIRENVLVLLLVICLSTLIVM
                     YTTGIIVEKMIKKKEEGQKNV"
     gene            complement(20256..21602)
                     /locus_tag="KR257_001906"
     CDS             complement(20256..21602)
                     /locus_tag="KR257_001906"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861214.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tetratricopeptide repeat protein"
                     /protein_id="HBH0030610.1"
                     /translation="MPRKILDISLIEDNKSDLTFFNIEEEDGDETLKALKQSYVTTNY
                     KEETLLNLQGALNSKSDTTSKELKLESYKRYNNALDLAYKNYITSAINMVNKALEINP
                     KDIDILNLRGLLKLLKCDFAKSFESFYTALCYENNHISRKYVNLISSEDFKTFLGRYN
                     HSIRFINEELNYESIHILENIIEEEPELIEPYVILSLLYDKLGNVKKREGYLDKLKEL
                     DKDNPVFEKNEEEKEDTSKKEEIKKVKRKKSILPYIIVGCVLIGMGIYLIQSKKRIEN
                     LNNQISSKEEKLSETDKKLGETSKKLEKTNKELNEVKNKEPEREITVADEEDLYYQAL
                     NLKKNKEYEKAIDNFKSVVSSGKTKKYISESIYQLAITNKLLGNKDEAIKYYKKYINT
                     YTKNDQYYDDSYYELGMFYYDNGDLKNAQQTFYSLRSEVPDSMYNNSKIKEILSEK"
     gene            complement(21784..22377)
                     /locus_tag="KR257_001907"
     CDS             complement(21784..22377)
                     /locus_tag="KR257_001907"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419857.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Fis family transcriptional regulator"
                     /protein_id="HBH0030611.1"
                     /translation="MNLNNITNYVQSICENISNVLDVDVTLVTKDLTRIAGTGIFRGK
                     IGETISEKSVYSLVLKDGKSYVINKEIEENCNKCANRENCKELADICTPVKMGEHILG
                     ILGIAAFNEEQKEKILSKDKELTAFVRSMSDLISFKLDELYKQEVKTIDDLEREAIEN
                     AIKKYGSNTEGMKKVAEALNIGIATLYRKVKKFNIKS"
     gene            complement(22442..23911)
                     /locus_tag="KR257_001908"
     CDS             complement(22442..23911)
                     /locus_tag="KR257_001908"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438615.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="VanW family protein"
                     /protein_id="HBH0030612.1"
                     /translation="MSNVNKKLVIAIGAVALVVIIFIGIMCMQFKGEKIAKNTYVNGV
                     NIGKLTKSQAKQELAKKYKLENVDFNYNDKSWKVKSKDLNLSTDLDKTVENAYNLNRK
                     SAFFGNLSKTISANFGKKSNLVVAINYDKNKLKAEMEKIAKEIDVDVKDATLDISGEK
                     VKVIPDSDGLKMDISKSMENFDNQTKKGNYKNELVVKATPAKVKKEQLANIDTNLGTY
                     STTFKTSQINRSINIKLATDNISNVLLMPGETFSFNKHTGKRSKENGYKSAPVIMEGE
                     MEEDYGGGVCQVSSTLYNSVLYAGLEIVNVKNHTIPSSYVPKGRDATVADSGIDFLFK
                     NNLKHPVYIKNYVSGNQIVCNIYGSAEDKQNITISTKLDGVSQTTMKRVNDPTMPKGK
                     EKVDKSGRNAYSVSTYRTFNDANGKKIKTEKIANSYYPKKEGIILVGTMEPKPEEKPN
                     TDENKNNQNTNNQNPNNQQKPETPPTDNKPNETQPQPQA"
     gene            complement(24026..25417)
                     /locus_tag="KR257_001909"
     CDS             complement(24026..25417)
                     /locus_tag="KR257_001909"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419854.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="UbiD family decarboxylase"
                     /protein_id="HBH0030613.1"
                     /translation="MNFRDLFEKAVDFIDEKRKSIVAISLSTLGVIALIIVFFLSSNE
                     FSVGNEANELLKIIEKRQYSIAVDYYTSIEKKFSDSKMERFNKSVSKKINKLLLNSGD
                     KYLDGDISQESFIGLINTVKELNKISIDVDDLLAQADRVREMYKEENTTYDIAINYIS
                     TVSILNGMGSNLDVYKQNIETIKESRDVYDSAVKDQKAYKYYEAIEKYNKVLKEDEKY
                     YSMAQNGKEQCIEEMYDYYISRAEEANTSGDYERALQYIEYLKDDYSDDEKVQSLEKK
                     YKKNLSLYTLTSDDIINVIAKKSGKDKANLSINSLPQMIKNNKYYYAEVYEYDKLINE
                     VLVSAKTKDLYSYKDGKKDYKVDYGDGYFRILEDGSYQFGITKDKAKFVLTNTLDEKE
                     NKYKKIEILDIEKADRYVKSKKSLEELFGKYKNIYYYAVVNKGLFRGKEVYAINIYNE
                     KIYAISENGLNEY"
     gene            complement(25583..25831)
                     /locus_tag="KR257_001910"
     CDS             complement(25583..25831)
                     /locus_tag="KR257_001910"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419852.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0030614.1"
                     /translation="MMICFAMTFALVLINSVMGVHIGLDYYFLMGSVLTVCLTIGIVL
                     CNARKIFDSKAIHKTRTKTVSNNKKQKSHSRDIKRKIS"
     gene            26097..28226
                     /locus_tag="KR257_001911"
     CDS             26097..28226
                     /locus_tag="KR257_001911"
                     /EC_number="1.11.1.24"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429391.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peroxiredoxin"
                     /protein_id="HBH0030615.1"
                     /translation="MPNLPSLGSKAPDFKANTTNGPIRLSDYKGNWIVLFSHPGDFTP
                     VCTTEFLCFAKYYDEFKKRNTELIGLSVDSNSSHLAWMYNISLLTGVEIPFPIIEDRD
                     MRIAKLYGMISKPMSDTSTVRSVFIIDNNQILRTILYYPLTTGRNIPEILRIVDALQT
                     SDRDNIVTPANWFPGMPVILPYPKNYKELKNRVNSCNKKYSCMDWYLCFVPDNYNDEE
                     VSKKIDNTCSWKKEHTKNIENECNCEHEHHDYLNKALDCKQEHKTDIKDDCNHEKKHT
                     KNTNKVHNSKQDKFKDKSCDEMNFNYDKDESCDKINSSYNKEDSSYEDFYKHNYKNYD
                     YTSEKNTKKIAMKTLKDSKKLVRPQITDPYNPIVENANCPDINPIVAEYVLGNPTNVD
                     AQLLDAVIFAFAEIDQSGNLFIPYPRFLNQLLALKGEKPSLKVIVAIGGWGAEGFSDA
                     ALTPTSRYNFARQVNQMINEYALDGIDIDWEYPGSSASGITSRPQDRENFTLLLTAIR
                     DVIGDDKWLSVAGTGDRGYINSSAEIDKIAPIIDYFNLMSYDFTAGETGPNGRKHQAN
                     LFDSDLSLPGYSVDAMVRNLENAGMPSEKILLGIPFYGRLGATITRTYDELRRDYINK
                     NGYEYRFDNTAQVPYLVKDGDFAMSYDDALSIFLKTQYVLRNCLGGVFSWTSTYDQAN
                     ILARTMSIGINDPEVLKEELEGIYGQF"
     gene            complement(28483..29082)
                     /locus_tag="KR257_001912"
     CDS             complement(28483..29082)
                     /locus_tag="KR257_001912"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419848.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribonuclease H family protein"
                     /protein_id="HBH0030616.1"
                     /translation="MAKQKFYAVKKGKNIGVYNTWDECKKQVNGFSGAEYKSFSTFQE
                     AKEYIDGSEKLSFQEDKEFIEAYVDGSYEHSVKMYGSGVVILKNNEVIKTYSEKGKEK
                     TLVSMRNVAGEIEASKIAMQYCIDNNVQNLILYFDYEGIEKWCTGVWKTNKEGTIAYK
                     NFYDSIKNKLNVKFTKVKAHSGNKYNEEADKLAKKAIGV"
     gene            complement(29100..32219)
                     /locus_tag="KR257_001913"
     CDS             complement(29100..32219)
                     /locus_tag="KR257_001913"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861210.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DEAD/DEAH box helicase family protein"
                     /protein_id="HBH0030617.1"
                     /translation="MDNIISVLNDVVFLDIEVSGLDCLNSEILEVGAVKVKDWKIYTY
                     ESLIKNKFEVPVEVFSVCKNLDKNDLEIANEIELVEDRLVNFVEDSFIICHDLSLKKK
                     FLEYHMPKLKNKFIDLIELAVILEPYHKDYSLEYLKNTLTNCNSKVENRALSDAIDII
                     NIVNCLLVKFNNYEKTTLEPLSFKINSYLKKFNLPTWEWSKFLEEANYDLSNNINIKK
                     EYNIFDSKEEKKKERETLKILNEEEKNYEELLKYKTIWENKEGFTYEYRPGQYELTKT
                     IRELFRNSEDEEKIACIEAPTGIGKSVGYLLPAILEARINKKRLLISTDTKELQIQLI
                     NKDIPNVLDSLGLNGKVSYGYIKGKNNYICIDRLEAYIDDYESQNPTKGEILSLIFLK
                     RLVEGGKYGDIEEINYLVFDNFKEISTHLRNVSCDPNMCRPKKCKKDCLYKNRIEELK
                     EEHITVVNHSLLAKWPYKDEKPLENIIVDEAHNLTEKGYDFFSSIINSKSLRYLLQEI
                     YPYEFIQNSSFIYKKYSRNMRKIKAFDKFYNVLKIGREDKQKIARSINLIIEEIDSIL
                     KFGNCNEYNNVSNYNLRWELNLQIDEIVGKLKKDGIDTEISYRAYSEKIKLSCEKIIK
                     NLVSIIIIIYRNIDDDSIDKEADIYKFGKAKTRDLEDIKIIFEIFLEYDEKDDYARIV
                     EIDKNYNDFEFRVVPLKIADLFEENILSQLEKGIFLSATLSLSESMSYFKNTLGIDRV
                     KNVEKIIEPIFDYKNRVSVVGFSDICEYRNSEFPNEMSKIISNISKITEGHTLALFNS
                     KDRQEKTYEILKKYLHSFNLEIYADKKGIRHLNDLNRKCVVLGSKGCFEGVDIPGDGL
                     VCVTLDKLPNLNPKDPLYFTIMKKYGIDYYTINYPQMTIKVKQAMGRILRSKYDYGCF
                     VIFDVGTNISVLKRLEKDLHDCKISKVNSNEFYTYIRRHLNKYRSLILKSVIFDTIKA
                     LNVDAKMDNNDVDKDIIKKDINENIRQRAVKGEVYHIDIIKKDMKVKYFDRNYLINLD
                     IFMREEDKN"
     gene            32440..33264
                     /gene="pdaA"
                     /locus_tag="KR257_001914"
     CDS             32440..33264
                     /gene="pdaA"
                     /locus_tag="KR257_001914"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438596.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="delta-lactam-biosynthetic de-N-acetylase"
                     /protein_id="HBH0030618.1"
                     /translation="MKKDSLKKYIMIGAFALILFGIASINFKSLDKTKTQISSPTLDT
                     HEYDWYFNPREDGKQPSPIKEADFFKKYGAYYVGNPNEKVIYLSFDAGYESGNTPKLL
                     DTLKKHNAKAQFFVVESYIKSNPELIKRMEKEGHLVCNHSKSHPSMAGITDFEKFKEE
                     ITSVEKAYKDVTGKEMPKYFRPPMGKFSEQSLKYTQDLGYKSIFWSFAYVDWYEKKQP
                     THEFAKNKIYSRTHPGAIVLLHPNSSTNTEILDEVLTHWEKEGYKLKTLDYLNNKK"
     gene            complement(33361..34146)
                     /locus_tag="KR257_001915"
     CDS             complement(33361..34146)
                     /locus_tag="KR257_001915"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896340.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HBH0030619.1"
                     /translation="MIVKIDNTLEKEFWQYVSHEESLNLFIIGYVENYGFSSQYQDIW
                     SQVEDGNITSIILKNKSTLIIYSFKNNFNIGEMKNHIKDLDVESISGKKCVIDRLISK
                     YKDFYEKLDNKFCVLKEIKEIDFSNMKEYKIENAQEKDIDEIGKLLNRSDYKVSKNYI
                     EERKVHLKEGNVRAYFIRNDDTMISTVSTGMETSFLAMVVSVSTDKRYRGKGLASYMV
                     YNLSKELLLEGKVPCLFYNNDVAGKIYHNIGYKEINEWTILFK"
     gene            34611..34976
                     /locus_tag="KR257_001916"
     CDS             34611..34976
                     /locus_tag="KR257_001916"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429379.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HBH0030620.1"
                     /translation="MKIRAEYTCLLEIVHDIIKGKWKTILIFELRQSNKTFSELQHNI
                     YGINQKMLIQQLKELRDFGIIDKISSAGYPLHVEYFLTNRGKKMLKAVEIMQEIGIEY
                     MLEHGQQEILDNKGICYNK"
     gene            35054..35608
                     /locus_tag="KR257_001917"
     CDS             35054..35608
                     /locus_tag="KR257_001917"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889225.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cysteine hydrolase"
                     /protein_id="HBH0030621.1"
                     /translation="MSIALILIDIQNDYFKNGKCELFQSEETAENAKKILLFFRKNNL
                     PVIHIQHISTDKTASFFLPNTHGSEINKIVFPLDNEEIITKHTPDSFFETDLQSILEK
                     KNITNLVICGMMSHMCIDTSVRTAKKLRYDITLISDACTTKNLSWNNIEINANTVHQV
                     FMASLQNSFADVKNTDKFLSNYHK"
     gene            35828..36502
                     /locus_tag="KR257_001918"
     CDS             35828..36502
                     /locus_tag="KR257_001918"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419842.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MgtC/SapB family protein"
                     /protein_id="HBH0030622.1"
                     /translation="MNHHILIQFEYIARIITAGFCGALIGYERKNRLKEAGIRTHFIV
                     ALASALIIIVSKYGFNDIVGTPGIGLDPARVAAQVVSGIGFLGAGLIFIRNQSVSGLT
                     TAAGIWATAGTGLAIGSGLYLVGIVSSIIIVIVQITLHRDRKWMKLPTAEQVSLKISN
                     STDSIEYIEGKFKKSNIEIINMNIKRLDGDWLEVVIYTKLPKGYKKTNLLKLFSDNPL
                     IETLEI"
     regulatory      36857..36953
                     /regulatory_class="riboswitch"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF01051"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="cyclic di-GMP riboswitch class I; Derived by
                     automated computational analysis using gene prediction
                     method: cmsearch."
                     /bound_moiety="cyclic di-GMP"
                     /db_xref="RFAM:RF01051"
     gene            37007..37183
                     /locus_tag="KR257_001919"
     CDS             37007..37183
                     /locus_tag="KR257_001919"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729350.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0030623.1"
                     /translation="MFRDEMDKCTHMLTAYISSLYDYCDFIDTQLDDFILEYGENVVE
                     SCLHQVMVLVSKYN"
     gene            complement(37371..37610)
                     /locus_tag="KR257_001920"
     CDS             complement(37371..37610)
                     /locus_tag="KR257_001920"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438585.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0030624.1"
                     /translation="MKCSNCGSVNIEKGILTTGGIYAETIGLKYRGDGKLDKVINKTF
                     PVQSTIYSDLCLDCGEIVRTYIKDNTDRNWCKDKK"
     gene            complement(37744..38553)
                     /locus_tag="KR257_001921"
     CDS             complement(37744..38553)
                     /locus_tag="KR257_001921"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438582.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MerR family transcriptional regulator"
                     /protein_id="HBH0030625.1"
                     /translation="MKDYYKIGEISKIYGIGRDSLMYYEEIGILRPVRDINGYRMYNI
                     SDIWKLNLIKEFRSLNFPMKKIKEYLDDRSIESTKNILNEELDLIDKKIAEFISHKEN
                     IIKRLSSIESVIQNTKIDEIEVVYIEKRKALELNADIKRDEDFDFLIQKLQKEYEDRF
                     NILGNNNIGSAFSTEAINKGIFNEFKSVFCFLESNEKVYNIVFDEGYYVTLNYTGSNS
                     NNKIYMEKVFKFIEENNYKIIADPIEIYKIDIHETGIVEEFVTEIQVPITK"
BASE COUNT        12742 a         6606 c         4009 g        15832 t
ORIGIN      
        1 agcttaaatc agaaatttat tctaaattag gtcatataga tatagattca aaattaatag
       61 tagatatgga ttttataaat aagaaaaata aaataataaa aaaatttaaa ataatctatt
      121 taataccgat actatttact ttgggaatga gtatttttat agcatttaat tataatcaat
      181 tgccagactc aattgccact cattggaaca taaatgggtc tcctgatgtt tttatagata
      241 aatcatttct taatgtattt aaattaatcg gtactgactt ttgtttaatg gttttattat
      301 atataacttc cattggatcc ataaagtcaa ggattaagat agatacaaat agaattgaag
      361 aaagtagagt tgaaaacatt aaatatttaa ataaaattgg ttatttgttt ttaatattga
      421 tgattataat gacaacacag ttttttacta ctcttttatc aataaaaaca aaactatcaa
      481 ctgctatgaa tattacaacg cttttagtta taatttattt aatagcaaca tatattaatt
      541 ccccaaattt aaaattcaac tcatcttatt ctccagaaga agatgagaag tattggatag
      601 caggcatcat gtataataat ccaaatgacc catcattaat ggttaataaa aggtttggta
      661 ttggatggac tataaatttt ggcaatcctc ttggaaaaat actatatatt gctatagctt
      721 tacttttaat tttttcattg tttagcctaa taaaatctct cttactttaa aataccataa
      781 aaggtatctt acttgtatta ttgggtatta tattttgtag gataagaaat atttcatatt
      841 atcgttgaag tatagtattt atatattact aagaatggag attttcataa tgttgtcaaa
      901 agctgaaatc aaatatttta atgaatgtgc ttctgagata ctttcttctg aaaaagttca
      961 acttatgaga acatttcctc atcatggcaa tgtttcatgt cttgaacata gtttgtcagt
     1021 agcatattat agttatctat tatgtaaaaa attgcactta agtgttgata ttcaaagtgt
     1081 tattagagga gctttactac acgacttttt tctttatgat tggcattaca aaggtgatag
     1141 aaaaggatta catggattta ctcaccctag agaagcatta aaaaatgcaa ctttattttt
     1201 tcaaataaat gaaaaagaaa cggacataat tttaaaacac atgtggccac ttactgttaa
     1261 gccacctaga tacaaagaag catttattgt atgtttgttg gataaatttt gctgtttagt
     1321 tgagacttta aagatacatt ctttattatc tccttaccat gtataggaca attcccacaa
     1381 cacttttata acttaatttt gaagaggtat taagtattat attcaacttg atacctcttt
     1441 actatttatt attttatata ataatatttt ctttataata tagttataaa taacaacttc
     1501 taccctcgat aacttcccct tcttatagac atgcttacta tcttaaataa caagaaacca
     1561 gctattaaat ttattagtat tgtttatact actctaacaa taatatcata aataaacctc
     1621 caaatagctt ctctttcact accttttatc ttaaactata tttttttctt aaaatttgta
     1681 aaaaacatag cataatcttt ataaatgttc taaaatttaa tttaagcatc aaaattagaa
     1741 aggatgatat tatgtttaaa gaaatgagat tgaaaaaaag agaaatgaca aaagaagata
     1801 ctgttgaagt attaaaaaat ggtgaatttg gtactttttc cactatatct gaaaatggtt
     1861 atccttatgg agttgctgta aattatgtat actttaatga ttctatttac tttcattgtg
     1921 caagaaatgg gcataagtta gataatatat cgaaaaacaa caaagtttct tttttagtag
     1981 ttgctaatga aagtgttatt ccagataaat ttagtactac ttattctagt gctatagttt
     2041 ttggaaaagc ttgcactgta gaaaatgaag aaaagaaaaa tgctcttgta gaaataataa
     2101 aaaaatattc taaaggattc tttgaagaag gcatgaagta catagagaag gatatgaact
     2161 taacaactgt tgttaaaata gaaattgacc atatttctgg taaagcttca cgtttataat
     2221 taagtaaaaa tacctaaaag tatatacagt cgcttttagg tatttttata tgatattctt
     2281 atatgttaag tctttttagg taatctctta tacctatctt ggcatcatca tttggtctta
     2341 tatcagaatt atctcctgct atatgaagta ttccatacgc tggataacct cctcttactg
     2401 aacatggaac tgacaaaaga gtcattccca tatgttgggc aaatatattc atagcttgca
     2461 aagctaattc tcctcctcca tgttgtgaac ctgctgtagc aaaacaacca aatattttac
     2521 cactcaaagg agtacctacc caaatatcag aaaaactatc cataaacatc ttcattggtc
     2581 cagatacatt tccataatat gttggtgaac ccataaatat agcatcataa tctaatattt
     2641 cttttccaga tttaattaca tttatacttt caaattcgtc tttgtattct ttggaattta
     2701 tcaaataata ttgaggaagt gtttttgcaa cttcgtcact tactctaaat atatctacct
     2761 cgatattcat ttcttcaagc gcttctttat attctctagc taataaatat gtactcccac
     2821 aaacactatg aaaaattact gctactttca tcattatccc cctaattaaa ctcaaattta
     2881 ttttttatat agtattttta ttatcaaaca ctgctaaata gtactaaatg gattcaaata
     2941 tacattactt tttattactt caattttact aaattcatct aaaaatctct tcataacatt
     3001 tttgaatata tcttctgtat caaaatgacc acaatccact atacacattc caatatcaag
     3061 tgcatcttgt gcctcatgat actttacatc acccgtaatt agtacttctg caccttgtct
     3121 cttagctttt tttacaaatt ctgaaccagc tcctgttaca acggctactt tcgttatgtc
     3181 tgtactaagg tttccaacta ctcttatgtg tttcatattt aatttctctt ttattttcct
     3241 tgaaagactt tctaatgtca tacttttatc aagtttactt attctaccta gtccaaatat
     3301 ctcaccttta ttttctaact tgtacaaatc atatgcaact tcttcataag gatgtgcatc
     3361 taacatagaa cttattaccc cacctaaaag cttctgtggt actacagttt caattttaac
     3421 ttcatttaca gtttctatat catttacact tccaagaaac ggattagagc cttctaatgg
     3481 cttaaattgt ccttcacctt ctattgaaaa cgtacaatca ctataattcc ctatatgacc
     3541 tgctcctgaa ttacttaaaa cctttctaag ttcatctgaa tagttatgtg gaacgtatac
     3601 tgctaattta tacaaatttt cgcttttagt tatatctaaa acctttgaat taccaaattc
     3661 cataatttcc ataaaatagt catttagacc atcaaatgct atatcaaaat tcgtatgcat
     3721 agaataaagt gatatatcat ttttaataag tttttggata agtctgcctt ttaaatctcc
     3781 actattaatt ttattaattt tcccaaatat aaaaggatga tgtgtcacaa ttaaatctat
     3841 atttttggat atagcttcat caataacatc ttcattagct tctaaagata ccaatacctt
     3901 ttttacatcc atatcaaaat ctccaactat aagacctaca ttatcccaat cctctgctaa
     3961 gtttagagga tacttttttt caatttttct agttagactc tttaatagca tatatacctc
     4021 ctatttattt tattaaattt tcaagttttt ttattgcaac ttcgctttcc tttctcttct
     4081 tatctatagc ttccccattt ttcccttcta atttattaac tatagaacta tatgtcttta
     4141 tctttttttc tataaaatca ttaaaaagag aatctttgtt ttctaaaagc tttattccaa
     4201 cctcataata tatctcatct tctattatag tatttttacc tgtatatttg gcaacaatta
     4261 tctcatatat tctaaaatct tctctcacta aaacttcttc taaaatttca tatccgttgt
     4321 ttaaaaggta atatctaagt tcttcttgtg cttgcattgg ctgtaatatt aatttttcta
     4381 cattatgtgc tacttctttt ttagcctcga gaagctcact tatcaagatt ccacccatac
     4441 cagcaattat cacttcttct acttccccta tttcaagtat ctctatacca gaacccaatc
     4501 gtaaatcaac tttatctaaa agattgttct gtatgacttc tttatgtgca ttgtcaagag
     4561 gtcctttatt aacatccgct agcactgcaa atggtacttt tccctctttt aacaaatata
     4621 ctggtatgta tccgtggtcc gtccctatat cagctatttt tttaccatct gacactaatg
     4681 atgctatttt caataatcta tctgttaatt tcaaatataa ttctcctttc aattcccttt
     4741 atttatagga tttaatccaa gttatagata ttagactgaa ataactacaa aaataaaatt
     4801 aaatctttac tacaaaatag ccatgagata tcacttatct catggcattt atcacaaaaa
     4861 catcaatgat gtatcttttt agtctaaata atctctaagt ttttttgatc tacttggatg
     4921 tcttagtttt cttagtgctt ttgcttctat ctgtcttatt ctctctctag ttacatcaaa
     4981 ctcttttcca acttcctcaa gagttctggc tctaccatcc tcaagaccaa atctaagctt
     5041 taatactttt tgttctctat catttaatga accaagtaca tcttctattt gttcttttaa
     5101 taaagaatat gctgctgcct ctgctggggc tggagcatca tcatctggaa taaagtcacc
     5161 taaatggcta tcttcttctt ctcctattgg tgtttctaaa gacacagggt cttgagctat
     5221 tttcattatt tctcttactt tatcttctgt catttccatt tcttttgcaa tttcttctgg
     5281 ttttggatct cttccaagtt cttgaagtag ttgtcttgat actcttatta gcttatttat
     5341 agtctctacc atatgaactg gtattcttat agttctagct tggtctgcaa tagcacgtgt
     5401 tatagcttgt cttatccacc atgttgcata agtactaaac ttatatcctt ttgtatagtc
     5461 aaatttttcg actgctttta taagacctaa atttccctct tgtattaaat ccaagaaaag
     5521 catacctctt cctacatatc tttttgctat acttacaact agtcttaagt ttgcttcaac
     5581 taacctttgt tttgctatct catcaccttc gtgcatcctt ctagcaaatt ctacttcttc
     5641 atgtggttta agtagaggaa tttttcctat ttcttttaag tacattctta cagggtcatc
     5701 tatacttatc ccttttggta aagataaatc cacagtttct atttctattg cagaagagtc
     5761 atcatgtgaa attgcctctg catcttcatc taagtggcct atacttaaat cgtcatcagc
     5821 aaccgaaaaa tctatatcag ctttatagtt ttttgtttct gttatttcta ttcccaaatt
     5881 tcctaaagtc tcataaagat tttctacttg atccttatca agttcagtct ccgaaaaagc
     5941 ttccattatc tctgcaagtg tcagagaacc ttgctttttt cctttttcta ttaatgtctt
     6001 agcagtaacc ttttttaact cttttttatt cgatttattt tccacactca aacctccttt
     6061 ctctacaagc tctttaaaat tttatttatc tcaactattt ttaaagcaat ttccataact
     6121 ctaccatcta cctctttcat atcattatta ttttctaatt cttgttgttc tctcaacaag
     6181 ctattaattt gctcttctaa tgagtttttt ctgatatttg ttattattcc ttctatttct
     6241 tttgtgttct ctaagtttat actattcaaa gaaattgaat ttaattcttt taagtattct
     6301 tcggatatgt ttaaactttt caatttgtca atagttattt tgtccaattc ttgattttta
     6361 atcatgtaat ttaaaatttc tttactttct ttcaataaaa aatcactttc ttctacttta
     6421 agtaacgcta tttctctaat ttttttgtct tctaacatta tttttattag agtttcttca
     6481 actaattgtt ttccgtcttg tctgacttcg actttttcaa ttactttttc ttctattttc
     6541 ttttgatttt tgttattata tggcttattg taatttttac cataaacttc tctctttata
     6601 gactcgacat taatatctat ttgattgctt aaatactttg tataaaaatc aatttcaaca
     6661 ggacttgtca attgttttat aattttagaa gcttcttttg cgaacttcac tcgttcttca
     6721 tctttttgaa tgttaaattc ttttttaaga tgatctattt tatattttat gtagtgagta
     6781 gaaacatcca tagctttttt ataatcacta agtccgtatt ttcttacaaa ttcatctggg
     6841 tctttagcat cttttaagtc taacactttt acattgatac ctaatttagt aagtatatct
     6901 atagctctta aagtcgcttt tattcctgct tcatcagaat cataagatat aatagcagtg
     6961 tccgcatatc tctttattaa aatgccttgt tgttcagtca aggctgttcc aagggttgct
     7021 actacatttt ttataccata ctgataaagc gaaattaaat ccatatatcc ttcaactaag
     7081 actatagttt tactttctaa attttttcta gcaaaattta atccgtataa gttctgtttt
     7141 ttattaaaaa ttaacgtgtc tggagaattt aagtattttg gcaaagaatc gtctaatact
     7201 cttcccccaa atcctattat atttcctcta taatcgaata taggaaacat aactctattt
     7261 ctaaatttat catagcaatt agttccatct ctattttttg caattagacc gcactccaat
     7321 aagtcttgtt ttttatatcc tttactgatt agagtattca taagtgaatt ccatgaatcc
     7381 aaagaaaatc ctaaaccaaa tttcttaata attttatcat ctagtcctct tattcttaaa
     7441 tattcatacc caagattttt gcttcccaat aagtttgaaa gataaaatct agctgcttcc
     7501 gtatgaatat cttgaaattt cttagatttt tctattttaa tcctagtttc ttcattcatg
     7561 ttagtgttaa tttctatacc gcatttattt gctaaaattt ttacagcatc cataaaatcc
     7621 aaattttcca ttttcatgac aaaatttatt acgtctccac cttcaccaca accaaaacac
     7681 ttataaatct gttttgacgt atttatataa aaagaaggtg tcttttcgcc atgaaatgga
     7741 cataatcctt tgtaattagc tccagattgt tttatattca tatattcaga tattatactt
     7801 gctatatcgc atctagcttt tatttcttca ataatgtctt ttatatcatt catattatca
     7861 ccttctggtg taattttttg tgttaacatt tctattctac actatattct aaatttgtca
     7921 atcactcaat atacacaatt cgactttttt tattgatatc cttcttatta atcaaaaaat
     7981 ttttattttt tatattaatt ctatcaatat taaatcttta tttatattaa ataatctaac
     8041 tatcaaatta taacttataa atttacctta gcaacgatta cgaataaaaa agaggctctt
     8101 gcctctttta ataattatta attgatttca ttaaatcttc aaattcatta aagcaaagag
     8161 attgagcacc atctgacaaa gcattttctg ggtcaggatg tacttctacc attattccat
     8221 ctgctccaca tgcaaaagat gccagtgaca taggttttac caaatatcta actccagtgg
     8281 catggcttgg gtctaccaca acaggaagac ctgtttcctt ttgaataatg ggtactgcag
     8341 ctaaatctaa tgtatttcta gtataatcat tatacgttct tatacctctc tcacacatta
     8401 taatattact atttccttct attgctatat attcagaagc acctatccat tcagtaattg
     8461 tggaagctat tcctcttttt aacataacag gtttattttg ttttcccact tcacttaaaa
     8521 gagtaaagtt ttgcatattt cttgacccaa tttgaattat atcacttata ctatacagtt
     8581 cgtccatatc tcttacatcc ataagttctg taataacagc cataccaact tcgtctttaa
     8641 ccgcttttaa tatttcaaga ccttcttttt ttaatccttg aaatgaattt ggagatgttc
     8701 ttggcttgta tgctccacct cttaaaatat ttgctccctg actttttaca aatttagcag
     8761 tctccaaaag ttgctcataa ctctctattg cacatggtcc agctattata agtttatctt
     8821 tttttacagt tatctttttg ttatttgtat ttatctctat ctttgaatta ttattaaata
     8881 ggttttcttt cataacctac aagctccttt acttcttctc tttcttcagc agataggagg
     8941 tttaaatgtt cttttattgt tttttcattt attataagtt cttcatttaa atccataagt
     9001 ggtatcaaaa cgaaagctct atcttgaatc cttggatgag gtattgttag tctttcatca
     9061 gtggaaacta catcattaaa aaatagtacg tctacatcta tagttcttgg tccccaatga
     9121 actattctct ctctgtgtag ttctctctct atttcttgac aatattctaa caactcataa
     9181 ggttcaaact ctgtttctat ttctacacac atatttagaa aatctgcttg ttctgtatat
     9241 ccccatggtt ttgtttcgta taagcttgat tcttttactt tatatataga atcactattt
     9301 ttcaaaagtt cacatgctct tgataaatta tcaaatctat cacccatgtt agtacctatt
     9361 cccaaataag ccttattcat ctcttgttct ccttatctca acaccaaaat agtcataaat
     9421 accatttaca ggagcctcag gctttctaac tctgaccata actccattta taagtataaa
     9481 tttattcaag acttcttcag caatattttc cgctaaagcc tccaaaagat taaattgttt
     9541 attttcagta atatctttaa caacattgta aacctcggca tagcttacag atttatttat
     9601 atcgtcacta agacctgctt ctcttgaatc aatataaagt tccatgtcga caaagaattt
     9661 ctgacctaga aaattttctt ctttaagaac accatgatat ccatagaatc ctagattact
     9721 aagtaatatt ttatccatta tattatacct actttctata tattgcatca gtcattctag
     9781 ctgccattaa attttcataa acatcatgta ctctaactat atctacgcca tctcttatac
     9841 caagaacagt agtagctatt gtaccttcta atcttttttt aggctcaact ggaagtactt
     9901 ttcctattac tgattttctg gatgtcccaa gcaaaatagg ataccctaaa tcttttaatt
     9961 catttaatct tctcaatact tcaatatttt gttcaaaatc cttgccaaat cctacacctg
    10021 ggtcaagtac tattttttct ttttttacac cacaactcat tgccatttct atacttacct
    10081 taaaaaagtc ttttattgac tccattatat ctttgtcata gtttgtccca tcttgattat
    10141 gcattataca cacttctgca tcatattttc ctattacaga agccatattt ttatcttttc
    10201 taagacccca aacatcattt accatagtga cacctaattt taatgcttct tctgcaacat
    10261 ctgccttata agtgtctatt gatattggta tatccaattc ctgtttaagt ttttttatta
    10321 cagggattac tcttcttagc tcttcgtctg agtctacata gctatgacct gggcgtgtag
    10381 actctcctcc taggtctatt atatctgcac cttggtcaac catatctttt gcatgttgta
    10441 ttgctatgtc caagttatta aaatctcctc catcagaaaa actatctgga gttacattta
    10501 atattcccat tatataagtt cttttaccat aatcaaacac aattaatgac actcccttaa
    10561 attaaatttt atctcaataa atgattatat ctataataaa ttactacttc atagtaatca
    10621 aactcatagc ctcggctcta gacgcaatgt ccttttcaaa tattcctctc actgctgatg
    10681 taacagtttt tgaacctggt ttttttacgc ctctcattgt catgcacata tgttcagctt
    10741 ctactactac taagacacca taaggttgta attcttccat tattatatct gcagcatttt
    10801 tagtgattct ttcttgtaat tgtggtcttt ttgccaatgt atctattact ctagcaagtt
    10861 tagaaagccc tgtaagtctt cctccttttg gtaaataagc aatatgagct tttccaaaga
    10921 aaggaactag atgatgctca caacatgaat aaaatggaat atcttttacc aatactaact
    10981 cttcatgttt ttcatctgca aaaagaactt ttaaatggtc tcttggttct tcactaagac
    11041 cagagaatat ctcttcatac atcctagcaa ctctatttgg agtttcgatt agaccttctc
    11101 tatctgggtc ttccccaatt gcctctagta tttctcttac tgcatgttgt atcttttctt
    11161 tatcaacttt attcatttaa actcccccca ttgatttgtg actagaagat tagttttata
    11221 acctcttttg tctcaatttc tttaaaaata taattataaa catctaaaag tctttgatag
    11281 tcataatttt cacttacttt tgacactagt tcaaaaagct cattattttc tttttttaaa
    11341 acttttagca attttttgtc ttttggtacc catttatcat ttatattaaa gtacccaatt
    11401 attatatctt ttaaatataa attcgtcaaa aaatgatatt caaaaacatc aaatttttct
    11461 ttatttttta aattcaatat ttttgctcca atatcttgct ttataaaaga cttttcctct
    11521 aatgacattt tactaggtcc ttctaagtaa atatctctac ttatatcttt tataatatgt
    11581 gatatattct ccctatcaaa cagtacttta gcatctttca tttctttcac aaagaaatat
    11641 tccctatttg ataataattt ttttacacca tcttttgaaa agtaatttac atcaaattct
    11701 attccctttt ttttaaacag tattctctct tgtttttccc cttcttttac aaaaacgaac
    11761 acatcaatat cgtttatcac tacatcataa agagtaaaat ctacatcttt actagaaccc
    11821 actaaatata cagccaaagt gttttggttt tctattattt tagtcatctc ttcattgtat
    11881 acttcataaa tacaacctat catcttttgt ctccaacaaa ttgttaatat tttaatttat
    11941 tctaataact tcactatttt atcaaaaaca acattttctt tattaaattt tattttgtca
    12001 atttctgtaa cctttatagc gcccataaga ctatttgtga caaaaacaaa atcaaaacta
    12061 ctaatttctg atatattaat ttcattttct atcaactcta tatgtaattc gtcacaaatc
    12121 tctataatcc ttttttttat tattccattt aatatcggta atctatcact aggagtgtac
    12181 actctttctc cttttataaa gaaaatattg ctcatagaac attctaatat tacaccttct
    12241 gaatttaaaa atataccatc attataacca gtcttatttg cgatattttt ggtatatatg
    12301 ttttcaaaat aattagtagt cttatgtcta tgaattaaac tattccccct aactattgga
    12361 gatatagcta atttaaaccc cttctcatac gtctcttgat tatatggaat atccctaata
    12421 gatatattat aaccttcatc aaaaacagta attctaagtg ctttattaat gacattttct
    12481 ttttttatat atgtaacaat ttcatttatc aagaaatctt ttttatagtt tatatctaaa
    12541 tccaaacaat ttattgagct tagcattctt tctatatgga tatctaaatc tactgctatt
    12601 ccatttttaa ctctaatagt ttcaaacaaa ccaattccaa atttacttaa actactatca
    12661 aaacctacat tattcttcat aatatcccct caaagccttc attatggatt tagctttatc
    12721 aagtgtttct tgatattctt catctgggtc agaatcccaa gtcattcctc ctccaacttg
    12781 aaagtagact tttttgtcat ttttgattat tgttctaatt gctatattaa aatccatatc
    12841 accattaaaa cctatataac ctattgaacc agtatataca tttctttgcg ttggctctaa
    12901 ttcgtctata atttccattg ctctaatctt aggtgctcct gttatagacc cccctggaaa
    12961 agttgctttt attacatcag tagcatcttt atcatctttt aactcaccta caactgtgga
    13021 aactaagtga tttacatttg catatggttc aattacaaat agctctggaa ctttaacact
    13081 tccagtttta gatattctcc caatatcatt tctttctaaa tctactatca taagtagttc
    13141 agctctatct ttttcactat ttctaagttc ttgttgaagt cttaaatctt cttctttatc
    13201 tttccctctt ggacgagtac cttttattgg tctagtttct attctcttat taacacatct
    13261 tataaatctt tctggagaat ttgataatat atgtgcatct tcaaagttta agaatgcccc
    13321 aaatggtgct gggctaaatc ttcttaagtc cctatacaat tcaaagcttg taagttctgt
    13381 ttctccactg aacctttgtg ttaaattagc ttgatatata tctccttgtc ttatgtactc
    13441 tctaacactt tgaactgcat ttttaaattc ttcctttgta aaattagatt taagtcttat
    13501 aggtgttact tctttttctt cataacatat gctatctata ccttttttct cttcttttaa
    13561 tattctttgt tctatatcat ctattatctt ttcttctaat tcgatatcta tgtttggagt
    13621 agctatataa gttttttgca caagatggtc tataactatt acatgattat aaaatccaaa
    13681 atacatatca ggcatctcaa tatcatctac agcagttcta ggtaaatttt ctatgtaatt
    13741 acctaaatca taagataaat atcccacagc acctcctaca aatggaagat tagtatcatt
    13801 tacaacccta tacttatgta gttcttcttt taaaacttct aaaggatttt catcagtatc
    13861 tttatacttt aataccttaa atggttggct acttataaaa gaatatcttc ccaatttttc
    13921 tttatccata gcactatcta atataaaact gtcatgttca tttctaaaaa tagtaaatat
    13981 ctcaaaagaa tttaatttag tatttatctc tcttatcata ttacatatgt accctttctc
    14041 tagcttctgt tataaaattt ttaagcattt catgaccata ctctgacaaa atagcttctg
    14101 gatgaaactg tactccttct attaaatatt tcttatgcct aattcccatt atttcccctt
    14161 tatcagtaat tgctgtaatt tctaattctt ttggaactgt attggagtca actattagtg
    14221 aatgatacct agtgacattt aaaggatttt taagtcccct aaaaactcct ttattagtat
    14281 ggttgatact atatactttt ccatgcacag gctgttgtgc ttttataata tctcctccaa
    14341 aaacatgtcc aatagtttgg tgacctaaac aaattcctag tataggtttt ttccccttaa
    14401 aatgctcaac aatatctatg caaataccag cttcttttgg agaacacggt cctggagata
    14461 acacaattac ctctggattt agttcttcaa tgtcacttat tttgatttca ttatttcttt
    14521 ttactacaac tgcttcccct aattcttcta tatattggac taggttgtat acaaaagaat
    14581 cataattgtc tatcataaga atcatactgt aaatctcccc cctaaaaatt attttatcaa
    14641 ctcagaaact gttacaaatt taaaaccttt ttcaatcatt tttggaataa acatatctaa
    14701 agcttcaact gtatcattag ttgcataatc atgcaaaagt attatatctc cattttgtac
    14761 tttattaatt attttatctg caatgctatt agctcctgga tttttccaat ctttcacatc
    14821 tacacctgtc cataaaacaa ctttatagtc atgctttttt gcaatttcta ttaagtcttt
    14881 ttctctataa cttccgaatg gtggtctaaa taatgtaggt tttttcccag ttacttcctt
    14941 caaaatgtct tcacacttaa caatctcctc ttctatctga ctagaactta aattacttat
    15001 atcaggatga ttgaaagtat gatttcctat ctcgtgacct tctttacttg ctcttactaa
    15061 tggttcttta taccattttg catgttttcc agctataaaa aaagtagctt ttacattgta
    15121 tttctttaat acatctaaaa cttgactagt ttctttagga tgaggaccat catcaaaggt
    15181 aattgctatt agcttttttt cccttgaacc atgtttaatc aaaacatttc cattagtatc
    15241 catcatcaaa gcagaaactt tactaaaatt agatattaac actattccac aaaacaaggc
    15301 tactgctatt aagcacttat atactgtctt ttttttccat gatgtcattt tttaacttcc
    15361 tttcaaatat tttagttatt tataaaaatt ttgagtgtaa tatgttttat agcttcctcc
    15421 aaatattact ccaactccaa tattattata gttccccaaa atattttttc tatgtccttc
    15481 agagttcatc caagcttcat gcgcatatat tgcattaatc tgtcctgctg ctatgttttc
    15541 tccagctgaa gtatatacta taccttctct tttcattctg tcaaatggag tttcattctt
    15601 cttatttaca tggtcaaaaa aattattatc tctcatatct tcactatgtt ttcttgaact
    15661 caaagttgcc tgttcactgt atctcaatga gtttaaccct ctttgatttc taacactatt
    15721 tacaaggtct ataacttcaa gttcaaaaca ttttttaagt tcttcgctat catctggata
    15781 taaattttta aactcatctt cagtgctttt atcaattatt aaatatgaac aaactctatt
    15841 ttcttcatga atatcgtaga aaattgtaat atacttacct tccttactta ttatatcata
    15901 ttgattttct gagtttatta tatatctggt atttcctttt ctcttatatt ttaatggtgt
    15961 aatcttagtt ctcactgttt gtctatcttg atttagtttt atatcttgat tttcacatga
    16021 attaatagaa ttactataaa gtgctactac ttcatcattt tcaagtccaa ccattgcaaa
    16081 ttcttttcca tattgattat atacatacca atcaaaacca tattcactaa tatcaattct
    16141 accaggtttg ccgatacttg ataaaacata gcttaaatta tctcctaagc ttattttttc
    16201 aaaattcttt atatctgact ctcctaagtt ctccccttca gtattatttg attgtaaatt
    16261 ttgacttttt tcttttttat ctttcttaga attatcattt atatttattt tgtctaaaaa
    16321 ttcattccat atttcacttt gaaaaaactt ttcttttaaa tcatatcctt cttttaataa
    16381 ttcaggacta taaaataaaa caataagtac tactaacact aaagcaatta atctcttcaa
    16441 tatatctctc cttcttaaaa tcaatcaaaa ttttttaata ttgcatttat taagttaata
    16501 ttgatagtgt atactaatca atatcattca tacctattta cagtaagtat tagaaaaaag
    16561 ctttatctac taattagata aagctacagt ctcaaggaaa atatttcatc taatgttcta
    16621 tcaaatatag atggcttatc aaatttccaa gtcccttcat aaaccaattc attatttaga
    16681 taaaaagttc cttgcccatg ttttttacca tgcataaatt cacctatata ctttttacct
    16741 ttttcccata tataagttcc cttaccatga atcaaattat tcttccattc tccttcataa
    16801 agtacttccc ctttactatt atagcaaata ccgtaccctt ccatctttcc acctttaaat
    16861 tcacctgcat atatacatcc atcactccac ttataaatac cttttccatc tttttttccg
    16921 tttttccaag ttccaatata ttcatcttta ctactatata acatatttcc aataccgctc
    16981 atcatatctt cctcaaaata acctatatat tcatttccat ttgaaaatat aaagtttcct
    17041 tttccatttt ttttatcttc tttaaattct cctatgtact ccataactgt tccttcatct
    17101 acaaaaaaag tatatgagcc tttcccctcc atctttccct ctaagaattt ccctacatat
    17161 acatccccat ttgaaaattt atagatttta ttttttggtt tttttgtatc gacatcatct
    17221 atatcgcgta ttgtttttcc ttccaattct aatacttcat tttccggagc aaaatcgccc
    17281 ctttttaaaa cacgtttctt catgttcttt atacttctaa tctctttgtt tacttcattt
    17341 atatatttca aataattatc atacaaatta acatattctt tagataaatt cataatgcca
    17401 ttcctccaac gttattccta ggtattttac taaatctatt aaatttatta tatcctaata
    17461 gtggtcatgt tttctacata ttaagtaatt ttttcaattt taattttaaa atgatatctt
    17521 ttaaagtgat acacaaatca ttaataaaac ctttattttc gtatactaaa tttaaataag
    17581 ctgagagata taatatacaa atttacatta taaactccca gcttgtaaaa ttttctataa
    17641 atcttttgct ttaaaccctc ttccctttac ttctgtaaca tcatttacag atataaaggc
    17701 ctttttatca tacttcaaag ctatatcttt tatctttggt atctcatttg atgaaactat
    17761 tgtatatata atcttctttt tttgatgagt gtatgcacct tctgcatcta aaaaagttac
    17821 acctctaact aaactcttca ttatatcttc tgctattaaa tcgacttcat ttgacattac
    17881 cataacagat ttttggtaat tcattgcatc tttaataaaa ctcattgaat acgcatttag
    17941 aaatagacct ataagagtgt ataatgctaa atccaaccca aataaaaaac ttcctgtaag
    18001 tactatcaag ccatttattg ctaaagcagt gtctttcatt tctatattct tcttaatttt
    18061 tagtattgca gctattatat ctgtaccacc ttgagaagac ctagttctaa atacaactcc
    18121 gactcctaaa ccagataata taccaccata tacactttga agcaatatat catgtatagg
    18181 tataatatta cttatttcct gagttgctcc taataataat gaaaatacaa tcatatttac
    18241 caaacttgaa atacaaaact ctttttcaag gtatatgaac cctaagataa atattggaat
    18301 attgattaaa aatgttaata aacctacatt tatatttgtc aaatagttta tagatgttgc
    18361 tatacctgta gcacctccac taagcagatg tgctggtctt aagaacccat ttattcctat
    18421 agatgtcatc aacatcccaa atagcattgt tgaatatctt aaaactggat gtttttgtag
    18481 ggtattctta acttcactca tttctttctc ccttcaatct ttctaaatct ttagaatttt
    18541 aaaagcttac tcttacatat attattcctg atgtaataga taatatttca aataaatttt
    18601 ttttataatt tcttgaactg tcatctatta catcatctat tatattatct ttttcatata
    18661 tgtctagtgc aatcttttat attctaatct ttaaaaacgt tcaaatcatc tcatttatgc
    18721 cttaaatgaa actttttcta gcataatatg atactgctta ttatttaact tgcaatatag
    18781 taaatttata gtattttttt ctaaatatct attttagcag taatttattt tattttagca
    18841 aattcaagtt tagtaattgt ctctttataa ttaattccta aatgaaattt ttctttttat
    18901 aatttcagta catgattttt ttatttcatt atttgcattt ttttcgttca gtttttattt
    18961 taaatttttt ttattttatt ttgttttaag tattcaaggt actcatctta attttatttt
    19021 ttatataaaa ttcattataa ttggaattag tattactgta attgtaccag agactccaat
    19081 agaaacacca ctcatagctc cttctatttc tccaagttca aaagcctttg tagttcctaa
    19141 agcatgtgca gatgttccaa gagcaattcc tttagcaact ggatgattta tattccccag
    19201 tttgaatact gtagaagcaa ccataccacc aaaaatacct gtaaaaatta tggctacaac
    19261 tgttattgat tctacaccat ttaaagaatt tgctaaagat attcccattg gtgttgttat
    19321 agattttgga attagtgaat ttattatact tacatctgaa ttagctattt tgccaattat
    19381 caatacagat acaaaagaaa tcactatacc acaacctatt cctacaataa tctcaaacat
    19441 atgcttttta aataattcaa attgtttata aagtggaact gcaagtacta ctgtgacagg
    19501 acctaaaaag aaatttagac tatcagctcc tatcttgtaa ttctcataag ggattttaga
    19561 tatgcttaaa aacaatatta ttcctacgat tgcaattaat aaagggttac atataggatt
    19621 acttgttttt cgttgaatgt atcttcctaa attgaaaaaa actattgtta ctattatacc
    19681 aaatactggt gtctgtaata cattatacat ttttttgtcc ttcttccttc ttttttatca
    19741 ttttctccac aataattcca gtagtataca ttactattag tgtacttaaa catatgacta
    19801 ataaaagcac taatacattt tcccttatta ggtctaatga ctttataagt gatacacctg
    19861 ctggaataaa aaatatagcc atattatcga ggaaaaatcc acttacattt tctatactac
    19921 tcaagtctaa aactttaaat tgtagtagta gaaataataa tagcatacca actatactcc
    19981 caggaataag tataattcct tgtataaagg aacttatata ctctcctatt acccagatag
    20041 ataaaattat taccaattga ttgaaaactt tcattttcca cctccaaaaa ttaaagagat
    20101 tgcttcaaat catatatttg tagttttatc aacaagcaaa tatctttctt taaaatagaa
    20161 agttataatt tgacacaatc tctttttaaa tttattttta ttttaattta ataaaataca
    20221 tacttggttg tttcaaaaaa cttaactata taaacctatt tttcacttaa aatttctttt
    20281 atttttgaat tgttatacat actgtctgga acttcacttc tcaaactata aaaagtctgt
    20341 tgtgcatttt ttaaatcgcc attatcataa taaaacatac ccaactcgta atatgaatca
    20401 tcataatact ggtcattttt agtataagta tttatatatt ttttgtaata ttttatagct
    20461 tcatccttat ttcctaataa tttatttgtt attgctaatt gatatattga ctcagaaata
    20521 tattttttag ttttaccaga agaaactaca cttttaaaat tatctatggc tttttcatat
    20581 tctttgtttt tctttaaatt tagagcttga taatataaat cttcctcatc agctacagtt
    20641 atctctcttt ctggttcttt atttttaacc tcatttaatt ccttattcgt tttttctaat
    20701 tttttactcg tttctcctaa ctttttatca gtttcactta acttttcctc tttactactt
    20761 atttggttat tcaagttttc tattctcttt ttgctttgaa tcaaatatat ccccatacct
    20821 attaaaacac agccaactat aatatatggc aaaatacttt tctttctttt tacttttttt
    20881 atttcttcct ttttacttgt atcttctttt tcttcttcat ttttttcaaa tacaggatta
    20941 tctttatcta gctctttaag tttgtctaaa tatccttctc tcttttttac attacctagt
    21001 ttatcatata acaaagataa aattacatat ggctctatta gttcaggttc ttcttcaatt
    21061 atgttctcta aaatatgtat tgactcataa tttaattctt catttataaa tcttatagaa
    21121 tgattgtatc ttcctaaaaa agttttaaaa tcttcagatg aaattagatt tacatatttt
    21181 ctagatatat gattattttc ataacataaa gcagtataaa aactctcaaa tgatttagca
    21241 aaatcacatt ttaataattt taaaagacct ctaagattta gtatatcaat gtctttagga
    21301 tttatctcca gagctttatt aaccatatta atggcactag ttatataatt tttatatgct
    21361 aaatccaatg cattgttata tcttttatat gattctaatt ttaactcctt agacgttgta
    21421 tctgactttg aatttaaagc tccttgcaag tttaatagag tttcttcttt ataatttgta
    21481 gtcacataac tctgttttaa tgcttttaat gtttcatcac cgtcttcttc ttctatatta
    21541 aaaaaagtca aatcactttt attatcttct atcaaagata tatctaaaat ttttctaggc
    21601 atgctttcta tgtcttgttt tatatcttta actaaaataa tactcacctc cactctaaaa
    21661 tatatattta agataacata tttaatatgt caagtcaaaa ctatacatat ttttccacca
    21721 ttctcataat aaaaaaggta atcctcttct tttcataaaa aggttacctc tttttcaata
    21781 ctattaactt ttaatgttga atttttttac ttttctatag agtgtagcta tacctatatt
    21841 taatgcctca gctacttttt tcataccttc tgtattactt ccatatttct ttatggcatt
    21901 ttctatagct tccctctcaa ggtcatctat agtcttaact tcttgtttat aaagttcatc
    21961 tagtttaaaa gatattaaat cagacatact ccttacaaaa gcagttaact ccttatcttt
    22021 tgaaagtatc ttttcttttt gttcttcatt aaacgcagct atacccaaga ttccaagtat
    22081 atgctctccc attttaacgg gagtacatat atcagctaac tctttacaat tttctctatt
    22141 tgcacattta ttacagttct cttctatttc tttatttata acataggatt tcccatcttt
    22201 taaaacaaga gagtacactg acttctctga tattgtctct cctattttac ctctgaatat
    22261 tcctgtacct gctatcctag ttaaatcttt tgtaactaaa gtaacatcta catccaagac
    22321 attagaaata ttctcgcaaa tactttgaac gtaattcgtt atattattta aattcaaagt
    22381 aatccctcct atttagattt atatttttta ttactctaca taaatcctat tcttgagaac
    22441 tttaagcttg cggttgtggt tgtgtctcat taggcttatt atcagttggt ggtgtttctg
    22501 gtttttgttg attatttggg ttttgattgt ttgtattttg attattctta ttttcgtctg
    22561 tatttggttt ttcctctggt tttggttcca tagtcccaac taatataata ccttccttct
    22621 taggataata tgaattagct attttttcag ttttaatttt tttaccattt gcatcattaa
    22681 atgttctata tgttgataca gaatatgcat ttcttccact tttgtctact ttttctttac
    22741 ctttaggcat tgtagggtca ttaactcttt tcattgtagt ttgtgaaacg ccatctaatt
    22801 ttgttgatat tgttatattt tgtttatctt ctgcacttcc atatatattg caaacaattt
    22861 gatttcctga aacgtaattt tttatgtaaa ctggatgctt tagattattt ttaaataaga
    22921 aatctattcc actatctgca acagttgcat ctcttccttt tggaacataa cttgatggta
    22981 tagtatgatt ttttacatta acaatttcta aacctgcgta tagcacagaa ttgtataacg
    23041 tagatgaaac ttgacaaact cctccaccat aatcttcttc catctcacct tccattatta
    23101 caggtgcact tttatatcca ttttccttac ttcttttccc tgtatgttta ttaaatgaga
    23161 aagtttctcc tggcataagt aatacattac ttatattatc tgttgctaat tttatgttta
    23221 tacttctatt tatttgagaa gttttaaatg ttgttgaata cgtacctaaa tttgtatcta
    23281 tattagcaag ttgctctttt tttacttttg ctggagtagc ttttactact aactcatttt
    23341 tatagttacc ttttttagtt tgattatcaa aattctccat actcttagaa atatccattt
    23401 taagaccatc agaatctggt ataaccttga ctttttcacc acttatatca agtgtagcat
    23461 cttttacatc tacatctatt tctttagcta tcttttccat ttctgctttt aatttatttt
    23521 tatcataatt tatcgcaact actaagttgc tttttttgcc aaaatttgct gaaatagttt
    23581 ttgatagatt gccaaagaaa gcactctttc tatttaaatt atatgcgttt tctactgttt
    23641 tatccaggtc agtagataaa tttaaatctt tgctctttac tttccagctt ttatcattgt
    23701 aattaaaatc aacattctct aatttgtatt ttttagctaa ttcctgtttt gcttgtgatt
    23761 tagttaattt tccaatattt actccattaa catatgtgtt ttttgctatt ttctcccctt
    23821 taaattgcat gcacattatg cctataaaaa ttattactac taatgctaca gctccaatag
    23881 ctataactag ctttttgttc acattactca tcccatactt ctccttacaa taaaattatt
    23941 tatatatccc tattattata ttactacata atgcgcctta aaaccccaaa aactttttaa
    24001 ttatatatta atttaatatt attaattaat attcatttag tccattttct gatatggcat
    24061 atattttttc attgtaaata ttaatagcat aaacttcttt gcctctaaat aagcctttat
    24121 ttactacagc ataataataa atatttttat attttccaaa caattcttct aaactctttt
    24181 tactttttac atatctatct gctttctcta tatctaatat ctcaatcttt ttatacttat
    24241 tttctttttc atcaagagta ttagttaaca caaacttagc tttatctttt gtaataccaa
    24301 attgataact tccatcttct aatattctaa agtatccatc accataatct actttgtaat
    24361 cttttttacc atctttatat gaatataaat ctttagtttt tgcacttacc aaaacttcat
    24421 ttattaattt atcatactca tatacttcag cataatagta tttattattt tttatcattt
    24481 gtggaagtga atttatagat agatttgcct tgtctttgcc acttttttta gctattacat
    24541 ttataatgtc atcagatgtt aaagtataca atgataaatt ctttttatat tttttttcta
    24601 aactctgtac cttttcatca tctgaataat cgtcttttaa atactcaata tattgtaatg
    24661 ctctttcata atctccagaa gtatttgcct cttcagctct acttatatag taatcataca
    24721 tttcttcaat acattgttct ttcccatttt gagccatact gtaatacttt tcatcttctt
    24781 ttaatacttt attatacttt tcaatagctt cataatactt atatgctttt tggtctttta
    24841 ctgctgagtc ataaacatct ctagactctt tgattgtttc tatattctgt ttgtatacat
    24901 ctaggttact acccatacca tttaatattg aaacagtact tatgtagtta atggcaatat
    24961 cataagtagt attttcttct ttatacattt ctctaactct atcagcttga gctaataagt
    25021 catccacatc tatacttatt ttgtttaatt ctttcacggt atttattaat ccaataaaac
    25081 tttcttgact tatgtctcca tctaaatatt tatcaccact atttaatagc aatttattta
    25141 tttttttaga aacagactta ttaaaccttt ccatttttga atcagaaaac tttttttcta
    25201 tacttgtgta gtaatcaaca gctatagaat actgtctttt ctctataatc tttaacaact
    25261 cattagcttc atttcctaca ctaaactcgt tactacttaa gaaaaatact attatcaaag
    25321 caattacacc taatgttgat aatgaaatcg caactataga tttccttttt tcatcaataa
    25381 aatctacagc cttctcaaat aaatctctaa aattcattat agttccctct ccatttaata
    25441 atctttatat tttatggtaa actaaatttc ttattggtta ttatatcata attcttgaaa
    25501 aaaaataaaa acacaagtta aatcgtgttt ttattttacc tatcaatcat tattttatac
    25561 ataaatattt cctttacata aattatgata tctttctttt tatatcccta gaatgactct
    25621 tttgtttttt attattactg acagttttcg ttcttgtctt gtgtatagct ttgctatcaa
    25681 atatttttct agcattgcat aaaacaattc caattgttaa acaaactgta agcacacttc
    25741 ccatcaaaaa gtaataatcc aatcctatat gtactcccat aactgaattt attaacacta
    25801 atgcaaaagt cattgcaaaa catatcatca tggagataac taaaattctt agaatttttt
    25861 tcaatccact cacctcgtat aatcactaaa attgacacta ccccttatcc attactatac
    25921 caaattagta aaaaaatagc aattactatt gtcatttata ttaggaaaat attaaatctt
    25981 tttaataaat atcttttttt gacataagga ttacttaact tttaataaaa tagtaacact
    26041 aatatgtatt aattaataga ataaaataaa tgataattta ttgaggggtg atttacatgc
    26101 caaatttgcc aagtttaggg tcaaaggctc ctgattttaa agccaataca acaaatggtc
    26161 ctattagact ctctgactat aagggtaatt ggattgtttt attttcacat cctggtgatt
    26221 ttacaccagt ttgtactaca gaatttttat gttttgctaa atattatgac gaatttaaaa
    26281 aaagaaatac agaactaatt ggtctaagtg ttgatagtaa cagttcacat ttagcttgga
    26341 tgtataatat ttctttactt acaggtgtag aaattccatt tcctattata gaagatagag
    26401 atatgagaat tgccaagtta tacggcatga tatcaaaacc aatgagtgat acatcaactg
    26461 ttcgctctgt atttattata gataataatc aaattctaag aacgattctt tattatccac
    26521 taactacagg aagaaatatt ccagaaatac ttagaatagt agatgcactt cagactagtg
    26581 atagagataa tatagttact cctgcaaact ggtttcctgg aatgccagtg attttacctt
    26641 atcctaaaaa ctataaggaa ttaaaaaata gagttaacag ttgtaataag aaatattcat
    26701 gtatggactg gtacttatgt tttgtaccag ataattataa tgatgaagaa gtgagcaaga
    26761 aaattgataa tacttgtagc tggaaaaaag aacatactaa aaacattgaa aatgaatgta
    26821 actgtgaaca tgaacatcat gactacctga acaaagctct tgactgtaaa caagaacaca
    26881 agactgatat taaagatgat tgcaatcatg agaaaaaaca tactaaaaat actaacaaag
    26941 ttcacaactc caaacaagat aagtttaaag ataagtcttg tgatgaaatg aattttaact
    27001 atgataaaga tgaatcttgt gacaaaataa attctagcta taacaaagaa gatagtagtt
    27061 atgaagattt ctataaacat aattataaaa actacgatta tactagcgaa aaaaatacta
    27121 aaaaaatagc tatgaaaact ttaaaagatt ctaaaaaatt agttagacca caaataacag
    27181 acccatacaa tccaatagtt gaaaatgcaa actgtccaga tataaatcca attgtagcag
    27241 aatatgttct tggaaatcca actaatgtag atgctcaact attagatgca gttatatttg
    27301 cttttgctga gatagaccag tctggaaatt tgtttattcc ttatcctaga tttttaaatc
    27361 aattacttgc tcttaaaggt gaaaaaccta gcttaaaagt aattgtagct attggaggtt
    27421 ggggagctga aggattctct gatgcagcat taacacctac atctagatat aattttgcaa
    27481 gacaggtcaa tcagatgata aatgaatatg ctttagatgg aatagatata gactgggaat
    27541 atcctggaag tagtgcatct ggaataacat caagacctca agatagagaa aactttacac
    27601 tcttactaac tgccataaga gatgttatag gagatgataa atggcttagt gtagctggaa
    27661 caggagatag aggatatata aattcaagtg ctgaaataga taaaatagct cctataatag
    27721 attattttaa tcttatgagt tatgatttta cagcaggtga aacaggccca aatggtagaa
    27781 aacatcaagc aaatcttttt gattcagact tatctttgcc aggatatagt gttgatgcaa
    27841 tggtaagaaa tcttgagaat gctggaatgc cttctgaaaa aatccttctt ggtataccat
    27901 tttatggaag attaggtgct actataacaa gaacttatga tgagcttaga agggattata
    27961 taaataaaaa tggatatgaa tatagatttg ataatactgc tcaagttcca tatttagtta
    28021 aggatggaga ttttgcaatg tcatatgatg atgctttatc aatattctta aaaactcaat
    28081 atgttcttag aaattgtcta ggtggtgtat tctcatggac atcaacttat gaccaagcaa
    28141 atatactggc tagaaccatg tctattggta taaatgaccc tgaagtatta aaagaagaac
    28201 ttgaaggtat ttatgggcaa ttctaataga atgtaggaaa attttatagt tatataaaaa
    28261 gcagatttta ttatattaaa taagttgtat ctaattaata ctattattaa ttgtttataa
    28321 attagatact tattttttca taatacaatc tgctttttta atcaaaattt atttaattat
    28381 aagttgttta attacaagtt gtttaattac aagttgttta attataaagt aggaatttag
    28441 atatactctt ataccatgta attatgtata aatatttttt tattatacac caatagcttt
    28501 tttagctaat ttatctgctt cctcattata cttatttcca gaatgagctt taacctttgt
    28561 aaattttaca ttaagcttat tcttaatact gtcatagaaa tttttatatg ctatagttcc
    28621 ttctttattt gttttccaaa ctccagtaca ccacttttca atcccttcat agtcaaagta
    28681 taaaatcaag ttttgaacat tattgtcaat acagtactgc attgcaattt tagaagcctc
    28741 tatctctcca gctacatttc tcatacttac taaagttttc tcttttcctt tttcactata
    28801 agtttttata acttcattat tttttaaaat cacaacaccc gaaccataca tttttactga
    28861 atgttcataa cttccatcta catatgcttc tataaactcc ttatcttctt gaaaactcaa
    28921 tttttctgac ccatcaatat attctttagc ttcttgaaaa gtagaaaaac tcttatattc
    28981 agctcctgag aatccattta cttgtttttt gcactcatcc catgtattat atacacctat
    29041 atttttacct tttttcacag cataaaactt ttgttttgcc aaatatatca ctcccactct
    29101 taatttttat cttcttctct cataaatata tctaaattta taagatagtt tctatcaaaa
    29161 tattttactt tcatatcttt ttttataata tcaatatggt acacttctcc ttttacagct
    29221 ctttgtctta tattttcatt tatatctttt tttataatat ccttatcaac atcattgtta
    29281 tccattttag catcaacatt caacgctttt atagtatcaa atataacaga ttttagtatt
    29341 aaacttctat atttatttaa atgtcgcctt atataagtat aaaactcatt gctattaacc
    29401 tttgaaattt tacaatcgtg taaatctttc tctaatctct ttaacacact tatattagtt
    29461 cctacatcaa aaatcacaaa acatccatag tcatatttgc ttcttaaaat tctccccata
    29521 gcttgcttta cctttatggt catttgagga taatttatag tatagtagtc tataccatac
    29581 ttcttcatta tagtaaaata caaagggtct tttggattta gattcggaag cttgtctaaa
    29641 gttacacaaa ccaaaccatc ccctggaatg tctacgcctt caaaacatcc ttttgagcca
    29701 agtactacac attttctatt taaatcgtta aggtgtctaa tccccttttt atcagcataa
    29761 atttctaagt taaaactatg taagtatttt ttcaatattt cataagtttt ttcttgtcta
    29821 tctttactat taaaaagagc taatgtatga ccttctgtaa tctttgatat attagatata
    29881 attttactca tctcatttgg aaattcagaa tttctgtact cacaaatatc agaaaatcca
    29941 actacagaga ctctattttt ataatcaaaa attggttcta taatcttttc cacattctta
    30001 actctgtcta ttcctaatgt atttttaaaa taagacatac tttcagataa actcaaagtt
    30061 gctgataaaa atattccttt ttctaattga gataaaatat tttcttcaaa taaatctgct
    30121 atttttaatg gcactactcg aaattcaaag tcattataat tcttatcaat ttcaactatc
    30181 cttgcataat catccttttc atcatactct aaaaagattt caaatataat ctttatatcc
    30241 tctaaatctc ttgtctttgc ctttccaaat ttatatatat ctgcttcttt atctatacta
    30301 tcatcatcaa tattcctata aattattatt attattgaaa ctaaattttt tattattttc
    30361 tcacaactca actttatctt ttcactatag gctctataac ttatttcagt atctatacca
    30421 tcctttttta gttttcccac aatttcgtct atttgcaaat tcagttccca tcttaaatta
    30481 taattactta cattattata ttcattacaa ttaccaaact ttaatattga atctatctct
    30541 tcaataatga gatttatact tctagcaatt ttttgtttat cttctcttcc aatttttaat
    30601 acattataaa atttatcaaa agcctttatt tttctcatat ttctactata ttttttatat
    30661 ataaagctac tattttgaat aaactcgtaa ggataaattt cttgtaataa ataccttaaa
    30721 gactttgaat ttataatgct tgaaaagaaa tcatatcctt tttcagtcaa attatgtgct
    30781 tcatctacta ttatattttc taaaggtttt tcatccttat atggccattt agctaatagt
    30841 gaatgattta ctactgttat atgttcttct tttaattctt ctattctgtt tttatataaa
    30901 caatcttttt tgcatttttt aggtctgcac atatttgggt cacaacttac atttcttaag
    30961 tgagtactta tttccttgaa gttgtcaaac actaaataat ttatttcttc tatatctcca
    31021 tacttgccac cttcaactaa tctcttcaaa aatattaaag ataaaatttc tcctttagta
    31081 gggttttgag actcataatc atctatatat gcttccagtc tatctataca aatatagtta
    31141 ttttttccct ttatatatcc gtaacttact tttccattta gacccaaaga atctaacaca
    31201 tttggaatat ctttatttat taattgtatc tgcaattcct ttgtgtcagt agaaattaat
    31261 aatctttttt tattaattct agcctctaat attgcaggca ataaatatcc tacactttta
    31321 cctataccag ttggtgcctc tatacatgca attttttctt catcttcgct atttctaaac
    31381 aactctctta ttgttttagt aagctcatat tgaccaggtc tatattcata tgtaaatcct
    31441 tctttattct cccaaatagt tttgtatttt aataattctt cataattttt ttcttcttca
    31501 tttaaaattt ttaaggtttc tctttccttc ttcttttctt cttttgagtc aaatatatta
    31561 tattcttttt ttatatttat attatttgat aaatcataat ttgcctcttc taaaaatttg
    31621 ctccattccc atgttggaag attaaatttt ttaagatatg aatttatttt aaaactcaat
    31681 ggctccaaag tagttttttc atagttatta aattttacta aaaggcaatt tacaatattt
    31741 attatatcaa tagcatctga taaagctcta ttttccactt tagaattaca atttgttaaa
    31801 gtatttttta agtattctaa gctataatct ttatgatatg gttctaaaat aactgctaat
    31861 tcaattaaat caataaattt gttttttaac tttggcatat gatactcaag aaactttttt
    31921 ttcagactta aatcatgaca tataatgaaa ctatcttcta caaaatttac aagtctatct
    31981 tccaccagtt ctatttcatt agctatttct aaatcatttt tatctaaatt tttacatact
    32041 gagaatactt ctacaggtac ctcaaatttg ttttttatta atgattcata ggtatatatt
    32101 ttccagtctt taaccttgac agctccaact tctaaaattt ctgaatttaa acaatctaat
    32161 ccactaactt ctatatctaa aaaaacaaca tcattcaata cacttattat attatccatt
    32221 tttatatccc ttcaagttaa accagcctaa cttatttaca atcatttctc tttatatttt
    32281 atcatttata tacactttat ttaagataat taatatcaac tttatatctt acagtaaact
    32341 tctttcattt attatttgta tatgtgaata tttttaacta taaatattca aactatatta
    32401 taagaaatat actttaaatt ttaaataaga ggtgaaattg tgaaaaaaga tagcctaaaa
    32461 aaatacatta tgataggagc atttgctcta atactttttg gaattgctag tataaatttt
    32521 aaatcattag ataaaacaaa aactcaaatt tctagtccaa cactcgacac acatgaatat
    32581 gattggtatt ttaaccctag ggaggatggt aaacagccat cacctataaa agaagctgat
    32641 ttttttaaaa aatacggagc ttattatgta ggaaatccca atgaaaaagt tatatatcta
    32701 tcatttgatg ctggatatga aagtggaaac actccaaaat tattagatac gcttaaaaaa
    32761 cacaatgcta aagctcaatt tttcgtagtt gaaagttata taaaaagcaa tccagagtta
    32821 ataaagcgta tggaaaaaga aggacattta gtttgtaatc attcaaaaag ccatccatca
    32881 atggcaggta ttacagattt tgaaaaattc aaagaagaaa ttacaagtgt agaaaaagca
    32941 tacaaagatg ttactggaaa agaaatgcct aagtatttta gacctccaat gggtaaattt
    33001 agcgaacaat ctttaaaata tacacaagat ttaggatata aatcaatatt ttggagtttt
    33061 gcttatgtag attggtatga aaagaaacaa cctactcatg aatttgccaa aaacaaaatt
    33121 tattcaagaa ctcatcctgg tgcaatagtt ttactgcatc caaattcatc aacaaatact
    33181 gagatattag atgaggttct tacacattgg gaaaaagaag gttataaact taaaacactt
    33241 gattatttaa ataataaaaa atagtatcat aaatttaaaa aaactctatc atgaattata
    33301 gtaaaaatat agttatttat aaatacttta attctcgata gagtttttta ttttttatag
    33361 ctatttaaaa agaattgtcc attcatttat ctctttgtat cctatattat gatatatttt
    33421 acctgctaca tcattattat aaaaaagaca tggaactttt ccttctaaca acaattcttt
    33481 actcaaattg taaaccatat aacttgcaag tccttttccc ctatatcttt tatctgtact
    33541 tacagagacc accattgcca aaaaactagt ttccatacca gttgacacag tgctaatcat
    33601 agtatcatca tttctaataa aatatgctct tacatttccc tcttttaaat gaacttttct
    33661 ttcttctatg taatttttac ttactttata gtctgaccta tttaaaagtt ttcctatttc
    33721 atcaatatct ttttcctgag cattttctat tttatactcc ttcatgttgg aaaaatctat
    33781 ttcttttatt tcttttaata cacaaaattt attatctagt ttttcataaa aatctttgta
    33841 tttacttatt agtctatcta ttacacattt ttttccactt atgctttcta catctaaatc
    33901 ttttatatga ttcttcattt ctcctatatt aaaattattt ttaaaactat aaattataag
    33961 tgttgactta ttttttaata ttatagaggt tatatttcca tcttctacct gagaccatat
    34021 atcttgatat tgagagctaa atccataatt ctcaacgtat ccaattatga ataaatttaa
    34081 actttcttca tgtgatacat attgccaaaa ttctttttct aaagtattat ctatttttac
    34141 aatcaagcag atatcctcct tctatgttaa taatgatata ccttataatt tatagtatca
    34201 tttaaaatca ttatattcta ccaaatattc taaattttta aatatctatg caatatgttc
    34261 gtatttattt ttatattctg ttactgcttc actccaagct tcttctactg aaatacctct
    34321 cttatttgca attttttgtg ctaattctat tattttcata gcttttcttg atatattcat
    34381 atatattcct cctctaaatt atcataagtt attttaaagt taaatttcta tagtcatgtt
    34441 atatatttat ttacttatat cttactaatt atttatgtac taaatatgaa ctacaataga
    34501 agaaatttag aacttaataa aacataaaat ttatatacag ttcatatata tttgtcatat
    34561 cacaagacaa gtgatataat ttattatcat tttactgggg gtgatatgct atgaaaataa
    34621 gagctgaata tacatgtctt cttgaaattg tacatgacat aatcaaagga aaatggaaaa
    34681 ctatccttat atttgaatta agacaatcta ataaaacatt ttctgaattg caacataata
    34741 tttatggaat aaatcaaaaa atgttgattc aacaattaaa agagttacgt gattttggga
    34801 ttattgataa aataagttct gctggatatc cattacatgt tgaatatttt cttactaatc
    34861 gtggtaaaaa aatgttaaaa gcagtggaaa taatgcaaga aataggaatc gaatatatgc
    34921 ttgaacatgg tcaacaagaa attctagata ataaaggaat ttgctacaat aagtaatcct
    34981 atacatacca aaaagtaagt aatttacatt ttttacaata gtattataat aaaaataaat
    35041 aggaggtata atcatgtcta tagctttaat attgattgat attcaaaatg attattttaa
    35101 aaatggaaaa tgtgaattat ttcaatcaga agaaactgct gaaaatgcta aaaaaatact
    35161 actgtttttt agaaaaaaca atttaccagt tattcatata cagcatatat caacagataa
    35221 aacagcttct ttttttcttc ctaatactca tggttcagaa ataaataaaa ttgtttttcc
    35281 actagataat gaagaaatta taactaaaca cacaccagat agtttctttg aaacagattt
    35341 gcaaagtatc cttgagaaaa aaaatattac taatctagta atctgtggaa tgatgagcca
    35401 tatgtgtatt gatacaagtg taagaacagc aaagaaactt cgatacgaca taactctaat
    35461 aagcgatgca tgtacaacga agaatttatc ttggaataat atagaaatta atgcaaatac
    35521 tgtacatcaa gtattcatgg catcactaca gaacagtttt gcagatgtaa aaaacacaga
    35581 taaattttta tctaactatc acaaataaaa acatacacta tgttaaaaga gcaagtttga
    35641 tttatttaag cttgctcttt aatcatttaa aattagatgc tttctatcat ttttatatac
    35701 ataatatacg tttatacatt ttatattcat atataactat tatataaatt ttaaacttta
    35761 ctatattcac ataaaaaatg tagtattata gtatatataa tattatatag aagggggtgc
    35821 tagataaatg aaccatcata tattgattca atttgaatat atagcaagaa tcattactgc
    35881 tggtttctgt ggggctttaa ttggatatga gagaaagaat agactaaaag aagctggaat
    35941 acgcactcat tttatagtgg cattagcttc agcacttata atcattgttt ccaagtatgg
    36001 atttaatgat atagtgggta ctccaggtat tggtctagac ccagcccgcg ttgcagcaca
    36061 agttgtcagt ggtataggtt ttttaggtgc tggattaata tttattagaa atcaatcagt
    36121 aagtggtctt actacagctg ctggtatatg ggcaacagct ggtacaggtc ttgccattgg
    36181 ctctggatta tacttagttg gtattgtttc aagtatcatt attgttattg tacagataac
    36241 acttcataga gataggaaat ggatgaaact ccctacagca gagcaagttt ctcttaaaat
    36301 ttctaacagc actgattcca tagaatatat tgaaggtaaa tttaaaaaat ctaatattga
    36361 aattataaac atgaatatta aacgccttga tggggattgg ttagaagtag ttatatatac
    36421 taagttacct aaaggatata aaaaaacaaa tttattaaaa ttatttagcg ataatcctct
    36481 tatagaaact ttagaaatat aatataaaaa ttgaagctta aaaataataa tatatttaat
    36541 caaggtcaat atataaataa ttacgggatg agtctatata aaattcatcc cttgtttttt
    36601 gccattcata tatatttttt caagatattt ttgttcatct attatctagc caagtaactc
    36661 ttgtgaacta aactttttaa tacaaaaact tcaatacaaa actaaatata atttttatta
    36721 aatattctac atgtatagtt tatttcttga gtgaaaaata gatttcatat tgttaagata
    36781 ctgttaaata tttcaatttt ctgacaagta tgttgaacaa taacttatcc tagtgtatta
    36841 ttttagttgt agaataaaac taaatcggca aaactagaga aatttagtga cgcaaagcta
    36901 tagggactaa cgcttataaa ataaactatg agttatgtca gccagttgcc aaaaagatat
    36961 tgttcttttt gttttatgaa agttttttag ggggatagta atatatatgt ttagagatga
    37021 aatggataaa tgtacacaca tgttaactgc ttatatcagt agtttatatg attattgtga
    37081 ttttatagat acacagttag atgattttat actagagtac ggagaaaatg tagtagaatc
    37141 ttgtttacat caagtgatgg tattggtaag taagtataat taaatagaaa ttgttttcta
    37201 gagaaccctt tttagtttta tctacattta aaaatgttat tatattaaaa aactaatctc
    37261 ccctatatgc aaagttttct tccatataac aatttcttcc catttatact ttttcacttg
    37321 tatctttaat aaaattcaac ttcaaatatt aatatacttc aaaaattatt ctatttctta
    37381 tctttacacc aattcctatc agtattatcc tttatatagg ttctaactat ttctccacaa
    37441 tctaaacata aatctgaata tatagtagat tgtactggaa aagttttatt tataacttta
    37501 tctaattttc catctcctct atattttaat ccaatagttt cagcatatat gccaccagtt
    37561 gttaaaattc ccttttcaat atttacactt ccacaattag aacatttcac atttataacc
    37621 ccctaaacaa ttattttttc atgctatctt ataatttaaa atataatttg ctaccgattt
    37681 tataacacag tggcaaatca acattttttc attctattta ccatctaatc cattgaaata
    37741 tagctattta gttataggaa cttgaatttc cgttacaaac tcctctacaa ttccagtctc
    37801 atgtatatct atcttataga tttctatagg gtcagcaatt atcttataat tattttcttc
    37861 tataaattta aacaccttct ccatatatat cttattatta gaattactcc cagtataatt
    37921 taaagttaca taatatcctt catcaaaaac tatattatat actttctcat tactttccag
    37981 aaaacaaaat acagatttaa actcattaaa tataccttta ttaattgctt cagtagaaaa
    38041 ggcagaacca atattgttgt ttccaagtat attaaatcta tcttcatatt ctttctgaag
    38101 tttttgaatt aaaaaatcga agtcttcatc cctctttata tcagcattta attctaaagc
    38161 ttttcttttt tctatatata caacctctat ctcatctatt tttgtatttt gaattacact
    38221 ttcaattgaa ctcaatcttt ttataatatt ttccttatgg cttataaatt cagctatttt
    38281 tttatcaatt aaatcgagtt cttcatttaa aatatttttc gtagactcta tacttctgtc
    38341 atctaggtat tcttttattt tcttcattgg aaagttcaag cttctaaatt cttttattaa
    38401 atttaatttc catatatctg atatattata cattctatat ccatttatat ctctaactgg
    38461 tcttagaatg cctatttctt cataatacat taatgaatct ctacctattc catatatttt
    38521 agatatctct cctattttat agtaatcttt catttatata ataaactcct ccgaaatctt
    38581 atttttattt taaatcaaca ttattactct ataatactat agtattagaa tatactaaaa
    38641 aaatctttaa aacaaggata ggaaaataaa catcctaata attaattatt aaaatatttt
    38701 tatattgtaa tattaggtat agtatttata acttcaactt ttttataaat atattttagt
    38761 tttatatagt tttatgttta cagctattat atccatctct atgtaatatt tttcatatta
    38821 aaactgattt ctatagatta atattttata aatttagtaa atgaatattt attatagtct
    38881 ttaacaaaaa atacaagaat aaacttaatt ttaataacta aaattaatta tgcaaaatta
    38941 ttaatatggt attaaattat gtataaaaag ttaattatga ataaaataat tatgcctttg
    39001 aaaaatcatt aaacttaaaa ttaattataa aaaaactcta ccttactaac tatacagctc
    39061 acaatctatc tatttatgaa aaaatatgat ataattgcat tcaaaaagga aatctttcaa
    39121 tatactagaa tttaagcatt aactaatttt atctaatatt attactaaac taaaaaatat
    39181 ttgtatttg
//
LOCUS       DAEPID010000034        39096 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.034, whole genome shotgun sequence.
ACCESSION   DAEPID010000034 DAEPID010000000
VERSION     DAEPID010000034.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 39096)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 39096)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..39096
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.034"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            311..793
                     /locus_tag="KR257_001922"
     CDS             311..793
                     /locus_tag="KR257_001922"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861978.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA-binding protein"
                     /protein_id="HBH0030626.1"
                     /translation="MYNNIKNILKENHITFEEYDHEPILSFEKAKEIREKLQYTGVES
                     KSLFIKDRSGNYYIFVTTEGKKLDPKTIKNVLGGKVSICSKEELTQKTQCLPGCVSPF
                     GYEKNISLVIDQDIFNHDKIIFSPGIPEKTFIITASGFKKVINNINNTTYKYIYINEF
                     "
     gene            complement(1492..2646)
                     /gene="nagA"
                     /locus_tag="KR257_001923"
     CDS             complement(1492..2646)
                     /gene="nagA"
                     /locus_tag="KR257_001923"
                     /EC_number="3.5.1.25"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898693.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="N-acetylglucosamine-6-phosphate deacetylase"
                     /protein_id="HBH0030627.1"
                     /translation="MKSFIYADKFFMKHGIKEKGYLSIINGKFGEFQQERPNVTDNVI
                     DFSGKYIAPGLVDTHIHGLLGADVMDNTFEAINTISKGLLKYGVTSFLPTTLTDSVDT
                     LSDSVENISNSFNRVEGAKIQGIYLEGPFFTEKYKGAQNEKYFKDPDINILKLWQKKS
                     KNLIRKIAIAPERKGSIELTRYATKNNISVSLGHSSATFEQVKQVVNSGAKVFVHTYN
                     GMSPLNHREPGMVGAAMVLKDTYAELICDGHHVSPIAVKIMMDAKSSNNIALITDCMR
                     AGAMEDGKYTLGKFNVNVKNSVARLNSGSLAGSVLTMDKAVRNIVDWNIATLEDAIKM
                     ATYIPALSCNIDNVCGSIHQGMEADFIVTDKDFNIYETYISGICKYKVNK"
     gene            complement(2729..3454)
                     /locus_tag="KR257_001924"
     CDS             complement(2729..3454)
                     /locus_tag="KR257_001924"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437811.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GntR family transcriptional regulator"
                     /protein_id="HBH0030628.1"
                     /translation="MIKRNDKRPIYDQLVEILRTKIENEMEPNDRMLSERKICDEYGV
                     SRTTVRLAMAELEHMGYIYKRHGKGTFVAALSQNSQNLMESYSFTDYMRTQGKKPGTK
                     VLSFEVVESTKYFSEKLGITPGEKMIKIMRLRLADDLPMMLERTYLPMKEFIGLTKEK
                     IEQKPLYEIFREDYGEIIKVADEEFSAGIISDKEAKLLEVPGDSPCLKLLRTTYNDDN
                     IVIEFTLSVARSDKFVYRVRHVR"
     gene            3721..4650
                     /gene="pfkB"
                     /locus_tag="KR257_001925"
     CDS             3721..4650
                     /gene="pfkB"
                     /locus_tag="KR257_001925"
                     /EC_number="2.7.1.56"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421339.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="1-phosphofructokinase"
                     /protein_id="HBH0030629.1"
                     /translation="MITVITFNPSIDRMYRVNNINIGEVQRVVSKNATAGGKGLNVSK
                     VCKILKENPLAMGFLGGFNGEFIKNELRKLDIQNKFTKIEQETRNCLNIIEDNKVSTE
                     FLEKGPIVEKSDLERFENDIEEVLKNTKILVASGSYCENMPIDYYEKIGNICRANNIK
                     FILDTSGEALKIALKSKPYLIKPNIDEIRHLLGINIESREEIILSGKKLIEMGAENVC
                     ISLGKDGMVYLNEDNVYYVKVPVVKCINTVGSGDSTVAGFSVGILRGYKIENLLKFAN
                     ACGISNALNMETGFVDLGEIDKYQDLVEVKKLS"
     gene            complement(4779..5696)
                     /locus_tag="KR257_001926"
     CDS             complement(4779..5696)
                     /locus_tag="KR257_001926"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437799.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Gfo/Idh/MocA family oxidoreductase"
                     /protein_id="HBH0030630.1"
                     /translation="MKNIKMGMIGLGSIAQKAYLPILTKSERFEFVGAFTPNKVKREK
                     VCSDYRIMQFDSIESLAKKCDCIFLHSSTETHYEIIKILLNLGVHVYVDKPLASTVSQ
                     GEELIELSTKKNLNLMVGFNRRFCPMYKEIKNNATEIVSINICKHGLNSLRNVKFDST
                     LIDDYIHVIDTALWLANEDVEISGEDLFLTDNKNLIFVSHKLKGKNFSINTSMHRDSG
                     TKLEQVEILSKGKIQRVKNLNVLEIEEGGNLTLKQSGAWVNILKQKGFEDISNHFIDC
                     IENNIKPAISGEECIKAQRLLEKIINSVK"
     gene            6166..7335
                     /locus_tag="KR257_001927"
     CDS             6166..7335
                     /locus_tag="KR257_001927"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012816427.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SIS domain-containing protein"
                     /protein_id="HBH0030631.1"
                     /translation="MKMFKLEEQKLKDLGAIITTNEIKQQPELWLETYEIYKSNKEKL
                     SRFIDTISNNHGQFRVIFTGAGTSAYIGNSILPYLKNKNDIRKYIFEAIPTTDIVSNP
                     YDYLKKDIPTLLISFARSGNSPESLAALNLGNKIVDNFYHLAITCNPEGELAKMTKND
                     ENNYLLLMPSKSNDEGFAMTGSFSCMMLSAMLIFDSLEDDVEKSYINAIVEMGRNVID
                     RKDEIHELINKDFDRVVYLGSGGLGGLTQEAQLKLLELTAGKISTVYDSPMGFRHGPK
                     SFIDENTLVFEFVSNCLYTRKYDLDVLEEIKRDKIAKFTCAVSVENENNFSGTKFEFK
                     EKYNKLPDVYLAMPYILFAQTIALFVSVKVGNKPDTPSATGTVNRVVKGVTIYEY"
     gene            7384..8235
                     /gene="gatY"
                     /locus_tag="KR257_001928"
     CDS             7384..8235
                     /gene="gatY"
                     /locus_tag="KR257_001928"
                     /EC_number="4.1.2.40"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892002.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tagatose-bisphosphate aldolase subunit GatY"
                     /protein_id="HBH0030632.1"
                     /translation="MALVTTTSMLKKAQDEGYAVGAFNVENMEMVIAVIEAAEELNSP
                     VILQTTPSTVKYAGLDYYLANAKVAAERVKIPVAMHLDHGSSFDLAMKALRSGYTSIM
                     IDGSHESFENNISISKSVVKACSPSLIPVEAELGKVGGKEDDLDGGNSNDYTNPKEAK
                     EFVDRTGISSLAIAIGTAHGLYKGEPKIDLDRLSEIKNVVSIPLVLHGGSGIHDDIIK
                     EAIKRGIAKVNYATELRIAYSKGVKKVLDEDSEVIDPKKYGLAGLQSVKDFVKEKIKV
                     CGSVNRV"
     gene            8561..10462
                     /locus_tag="KR257_001929"
     CDS             8561..10462
                     /locus_tag="KR257_001929"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891994.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcription antiterminator"
                     /protein_id="HBH0030633.1"
                     /translation="MRERIILETLKNSSGYLNIDYFADKLGVSTRTIRNEIKKIETIK
                     ECNGFKLEYKSKLGYILNIKDQDKFEHYLRNLPSDLVENPEQRLESIIVELLVNEGYK
                     TIEQLSKKFLVSSSQIKNDLKKIDEKIKDTELKLERKAHYGIKIEGSIKEIQSILVDS
                     YFRGNRNITEYRNKFIDNLKLANIRSTIKNVLNEHDLEANLTELEEILAQIIILYIRV
                     SMRVAGNASDLKLYTEDLIIDKLLDKIFRDKKYNLNYDEKYYLKELIKLKTKDKKATI
                     KNIDKNKLQDIMFEFFREIDKKYNSNFLEDKEFFNLFYLHIACLIERIKKNHKIINPF
                     SVKISQQYPTVFNLSIQFSKIIENEYHIKISQDEIGFIATHIAVPFEKREEANFNKKY
                     KIAIICSSGGGSAFLINLRLKEIFPNAEIRNFSLLEEKAVIEFAPDLIFSITNLLFEI
                     NAPVILINEILDELDYLDIKESVRFADHIGNISSPKQYILGLFDKNHFRCIKDKAKYK
                     DILDSMSKCIVDEGACSPTYPKDVWERESYLSTIYTNGVAIPHPIEMTGNKNIISVAL
                     IQTDIIYENRVPKIIFMISLIKGNLELHKQISKYLSKIMANKDMVDMLNKSQSYEEFM
                     YKLKIYLGG"
     gene            10465..11508
                     /gene="ypdE"
                     /locus_tag="KR257_001930"
     CDS             10465..11508
                     /gene="ypdE"
                     /locus_tag="KR257_001930"
                     /EC_number="3.4.11.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891992.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aminopeptidase"
                     /protein_id="HBH0030634.1"
                     /translation="MNIEFFKRLSEADGIASNEEEVRHVLLEELKAYSDKIICDGLGS
                     IIFSKIKDESAPNVMICAHMDEVGFMVRSIDKLGMIHLITIGGVKPLAQFVQKVRITT
                     KEGKKIPAVINATYNNGKAENIYADIGAYTEEDVYNLGINVGDMVTYTTSFEEFTLPD
                     RLVGKAFDDRIGCFVMGEVLKELRKENLNCNIHFAATSSEEVGIRGAKTSTQLINPDI
                     VFVIDVACAKNEFVRDYTNQKQIDKGVMLMHRDRTLVPSRKMIDYVMEIADKNNIPLQ
                     HDMFESGGTDGGEAHLVNEGKPCVVTCVPVRYGHCAFSIVSNKDLENIIRLYTQLILN
                     FDEEQYKHIRNFI"
     gene            11523..11828
                     /locus_tag="KR257_001931"
     CDS             11523..11828
                     /locus_tag="KR257_001931"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421329.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS lactose/cellobiose transporter subunit IIA"
                     /protein_id="HBH0030635.1"
                     /translation="MSTEVQIMELISTAGESKSKAFEALKKVKSKDFKGAKLLIEEAR
                     KIDIEAHRIQTELITQDLNEDVESPAMSLLMVHAQDHYMTSQLAKDLIEALIYCLDK"
     gene            11925..12260
                     /locus_tag="KR257_001932"
     CDS             11925..12260
                     /locus_tag="KR257_001932"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421322.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIB"
                     /protein_id="HBH0030636.1"
                     /translation="MKILLCCAGGFSTNMLMQNMKKVVKESAKLNEKDFEFTAIPADS
                     IESEVDDWDIVLIGPQIAHKIDFLKGILEPKNKPFAVIDKDVYGKMDGATVMKLALIT
                     YKKHQLAQG"
     gene            12292..13614
                     /locus_tag="KR257_001933"
     CDS             12292..13614
                     /locus_tag="KR257_001933"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437786.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIC"
                     /protein_id="HBH0030637.1"
                     /translation="MFSKFEAFMNRVFMPLAHKVDNQRHLGSIKAGMVAMTPFTILGS
                     IFAILPALPNMLGENNPISKFILNNSAILDLPVSLSIGLIGLYACMCIAFNLGNYYKL
                     YIPGCVALSTFSFLFLVASFTPDGALEIGNLGAKGLFTGMIAGLGSVELYNFCNKKNI
                     TIKMPENVPDFVSRSFELIPTTIIVCGTFIVARFISLKVFGELPPQILTQFLSPLVGS
                     MDNPWSVLALNFAICTIFFFGIHSSVFSPITRPIMITFIAENIAAMQAGETIPHFFTA
                     GASSAFFGFTGCGISIGCVIACMLSKNASYKKIGRVSLFPALFGINEPILFGAPIILN
                     PIMFIPHVFGGAIIGTLPMFFMHWGWLAKPVFDPPYVGVFLEGFLTNGDWHSILANAL
                     QLVLAVLLYWPFFKIMERQQNNKKQKEETKNIFSKEEEDLLDDLGLDF"
     gene            13624..14694
                     /locus_tag="KR257_001934"
     CDS             13624..14694
                     /locus_tag="KR257_001934"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903771.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aminopeptidase P family protein"
                     /protein_id="HBH0030638.1"
                     /translation="MNNTMERLVSLIYKRGVDALLIKAKNTKRYIGALSGSGVYVLVT
                     KDKNYQILDGRYIDEADKKTTGFIKRIVSQGSYIPTIIELLKELNIKKLAIENQAMSI
                     QEYLSLKNEGFEINLITNELWKLRAIKSKEEIELIKKACEITDEVFDEVISEIKKDMT
                     ELEVSALIQYHALKKGASGMSFETIVVSGERGAMPHGRPTNKKLKVNEAITIDFGVVY
                     QGYQSDMTRTISIGKPPKIIKEIYDVVLEAQLSAIESIKEGTRASDVDKVARKIIDKH
                     GFGEYFNHGLGHGIGLGDGEVPTLNPNSEDILVEGMVMSCEPGIYIPNVGGVRIEDDI
                     VIIDGKGVPLNKTSKEFIILGE"
     gene            14699..15886
                     /locus_tag="KR257_001935"
     CDS             14699..15886
                     /locus_tag="KR257_001935"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437779.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pyridoxal phosphate-dependent aminotransferase"
                     /protein_id="HBH0030639.1"
                     /translation="MKYNFNKVLNRKEGNCRKWSNHVIKEKFGLNEDAIPMDLADIDF
                     ECAPAIKESILKRASVGDYSYTFIGDDFYDAIINWNKRRFDVYIEKDWIKLTFGTVST
                     LHYIVQAYTKEGEGVLINTPAYDPFAEAVVNNNRKLCCSSLKLDNNRYYLDLEDMENQ
                     MKYENIRLLIFCSPQNPSGRIWTKEELYQVSELCLKYNVILVSDEIHRDIIFKDYRFV
                     SLWNAHPEIYKNSIICVSPNKGFNLGGLKTSYVLIRDVKIRETLLERLKSNSITSPNV
                     FAIPAIVAAYNESEEWLDAMTSYVEENFEIVYDFFETNIPKAKVMKSDSSFLAWIDVR
                     EVFRNEEESKEFFRHANLTMVVGSYFVKDGDGFIRINVGCPRETLNEALNRIKKTYIS
                     MYC"
     gene            complement(16083..16955)
                     /locus_tag="KR257_001936"
     CDS             complement(16083..16955)
                     /locus_tag="KR257_001936"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898679.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aldose 1-epimerase family protein"
                     /protein_id="HBH0030640.1"
                     /translation="MNILQNENLIIESSSFGAELTKIFSKKYDKNILWDGNKKYWGRQ
                     SPILFPIVGKLFDNETIIEENLYSMTQHGFARDMDFEIVDKGDTFVTYKLTDNESTLK
                     KYPYSFELIINYTLNDNSIEVEWIVKNTDSKDIFFSIGGHPAFNLPFYEQNDFSKHYL
                     EFKSKNDVEKINLNGSFTDDIIPIGKLKNLQLNPEVFKNDALIYTNIDEVSICNNDGS
                     KYVTISMEDFPLVGIWTPYYSETNSTAPFLCIEPWYGLADSINSNKIYKDKKFINKLS
                     KGKVFTASYNINIH"
     gene            complement(17349..17540)
                     /locus_tag="KR257_001937"
     CDS             complement(17349..17540)
                     /locus_tag="KR257_001937"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421310.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0030641.1"
                     /translation="MDDFSKLKSLYEDGYRCIYHDCVDNNYTIYLKNFYTEGSETIEL
                     SSESDFSQFKDYIDGLRMS"
     gene            17760..18806
                     /gene="cobT"
                     /locus_tag="KR257_001938"
     CDS             17760..18806
                     /gene="cobT"
                     /locus_tag="KR257_001938"
                     /EC_number="2.4.2.21"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009906494.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nicotinate-nucleotide--dimethylbenzimidazole
                     phosphoribosyltransferase"
                     /protein_id="HBH0030642.1"
                     /translation="MSLLESISKNIYSLDNSSIEKTKQRLDRLIHPTGSLGKIEDICM
                     QLAGIFGNENFDTSKKVIIAFAGDHGVYEEGVAPDPQNITKLQFPNFSKGLCGVGVIS
                     KFVGADVVAVDVGINCDEKLDGVLDYKIRKGTSNMAKGPAMSKQEAIRCLEIGIEIAE
                     QCIEKDYKVIGIGEMGIANTTPSTAIISVISGCDPLEVTGIGAGLKKERLKHKAEVIR
                     KAIEINNPNPTDGVDILSKVGGFEIGSMAGVILGCSANRIPVVIDGFISYAAALIAYK
                     INPKTREYMIASHLSAESGTKRALDILKLDPLLNMDMRLGEGSGAALAFDIIEASNYT
                     YKNMATFDEIDMGR"
     gene            18838..19398
                     /gene="cobU"
                     /locus_tag="KR257_001939"
     CDS             18838..19398
                     /gene="cobU"
                     /locus_tag="KR257_001939"
                     /EC_number="2.7.1.156"
                     /EC_number="2.7.7.62"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009906489.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional adenosylcobinamide
                     kinase/adenosylcobinamide-phosphate guanylyltransferase"
                     /protein_id="HBH0030643.1"
                     /translation="MSKIILVTGGARSGKSNFAEKLCFDRNNNTAYIATSIPFDDEMK
                     DRVKKHQENRPRNWNTYEIYEDIYSIIKEIYKEHETVILDCVTLLVNNLMFEHNLNIE
                     ESSQEEINKLEQYIKEQVVKLIEEIEKTNLYFVFVTNELGMGIVPGNKLSRIYADIVG
                     RINQYIASKSNEVYFVVSGIAMKIKE"
     gene            19408..20181
                     /gene="cobS"
                     /locus_tag="KR257_001940"
     CDS             19408..20181
                     /gene="cobS"
                     /locus_tag="KR257_001940"
                     /EC_number="2.7.8.26"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425769.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="adenosylcobinamide-GDP ribazoletransferase"
                     /protein_id="HBH0030644.1"
                     /translation="MKRFILILQFLTRIPIKLNVGFDDEFYKSIVYFPLVGFVIGILS
                     YLIGWISMLLFEPFIASIIITLAGVLITGGLHIDGLGDTFDAIYSYRDKEKMLEIMKD
                     SRLGTNSLLAIMFVLLLKVGFVYDIISNNSLWVIIFMPMIARLGVMLLTYKTVTPREK
                     GMGNLFIGKLTTSMLITAIIYTLLIVALITKFIFLLPNIVLIKVLGSIIVVFVFIILF
                     KKHIYKKIDGVTGDILGCGIELSELVYLIYIYLLIFMFF"
     gene            20201..20815
                     /locus_tag="KR257_001941"
     CDS             20201..20815
                     /locus_tag="KR257_001941"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009894012.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="histidine phosphatase family protein"
                     /protein_id="HBH0030645.1"
                     /translation="MIRLILIRHALTNDNKKGRLSGHINSCISEEGKLQINKITRYLS
                     NENIDKVYTTPSTRTKDTVEKISKLKLLEIEEKEALREISFGDFEGRTFEEIKIKYPN
                     EFEKMIKEGNNYRYPNGESLIDSYKRVAKEIDNIILENDSNLDTKTILICSHAGTIRN
                     IITHLISGSYKYHWNFKIDNASITVLEIDGGFAVIDKMNFTDFI"
     regulatory      20882..21061
                     /regulatory_class="riboswitch"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00174"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="cobalamin riboswitch; Derived by automated
                     computational analysis using gene prediction method:
                     cmsearch."
                     /bound_moiety="adenosylcobalamin"
                     /db_xref="RFAM:RF00174"
     gene            21191..22690
                     /locus_tag="KR257_001942"
     CDS             21191..22690
                     /locus_tag="KR257_001942"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012816426.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cobyric acid synthase"
                     /protein_id="HBH0030646.1"
                     /translation="MLQGTASNVGKSVLVAGLCRIFKQDGYTVAPFKSQNMALNSFIT
                     KEGLEMGRAQVFQAEAAKIEPIADMNPVLLKPSGNNKSQVIVRGKVVGEMPSSKYHDY
                     KLELVDVLKETFNSLNSRYDIVVMEGAGSNAEINLKDRDISNMGMAEIADAPVIIVGD
                     IDRGGVFASLAGTMLLLNEDEKRRVKGVIINKFRGKKELLQDGVKMLEDIIKVPVIGV
                     VPYTDIKIEDEDSVTTRFKKKMNKSDIHIEIIRTPHMSNFTDFNIFETQEDVSIRYVD
                     YGESLGNPDILIIPGTKSTIDDLTYIRKSGLESQIKNLHSQGKLIFGICGGYQMLGKK
                     LKDPYHVESEIEEVDGIGLLDTETTFEKEKTTTQVEATIVECISEYMNNLKGKKVKGY
                     EIHMGITKRGNDVRSLDLITKKLDKEVNYTEGSVNKEGNVIGTYLHGIFDEISFTRAI
                     LNNIRKKKGLGELESKVNSFNEFKDKEYDKLADFLREHLDIEKIYEIMK"
     gene            22729..24105
                     /locus_tag="KR257_001943"
     CDS             22729..24105
                     /locus_tag="KR257_001943"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421301.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cobyrinate a,c-diamide synthase"
                     /protein_id="HBH0030647.1"
                     /translation="MKKILIAGTNSGVGKTTISLGIMQALVKRNMKVQPYKVGPDYID
                     PSYHTFITGRHSRNLDSYMLDDEKIKYIVNKSSKDADISVIEGVMGLYDGFGIDLDNC
                     TSSHTSKVLKSPVILVINGKSMAASSAAMVLGYKELDKDVNIKGVIVNNVKTNSHYQI
                     IKSSIEKYCNVEVLGYFPPNNKFSLESRHLGLVPSVEMKSLREKFYTLADEIEHYIDI
                     DRIIEISESDEFESDFDFQTLIENNKIKEHVNNKSIAIAYDKAFNFYYRENIELLEEL
                     GLEINYFSPLEDVSVPNADYIYIGGGFPEIFGKELEANESMRTSILEAHNNNIPIYAE
                     CGGLMYLGEKLLNQEEQEFNMVGIFSGISKMTSSLKRFGYCIGVAKENTLLSKKGESI
                     KGHEFHHSIFESDEKCVYSMRKERDGNIVEEWDGGYSKGNTLATYLHTHFYNNLNCIE
                     NFLKKGNE"
     gene            24106..25077
                     /locus_tag="KR257_001944"
     CDS             24106..25077
                     /locus_tag="KR257_001944"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903766.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cobalamin biosynthesis protein"
                     /protein_id="HBH0030648.1"
                     /translation="MSILSIYIGYVTDLIVGDPYSFPHPVRFIGKLINFTQGIIRKVS
                     KNDRQLKLGGFILWFITVGITYLTTYAIVKLFSFNILLSIVVNSFIIYTTLATKCLKD
                     EALKIYNVLKTEDIEKSRIQLSYIVGRDTTNLSEPEIIRATVETVAENTVDGIIAPMF
                     YAFIGGAPLAMAYKAINTLDSTVGYKNKKYKDIGFASAKIDDIANYIPARISVILMTI
                     GSFFLNYNYRNCFKISIRDRKNHKSPNCAFSEGAVSGALGIQLGGTNVYFGEKVYKPT
                     IGDKLREIDKEDIIKTNKIMYASSFVSMLVFTLIYVLCRMILINLII"
     gene            25109..26179
                     /locus_tag="KR257_001945"
     CDS             25109..26179
                     /locus_tag="KR257_001945"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903764.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aminotransferase class I/II-fold pyridoxal
                     phosphate-dependent enzyme"
                     /protein_id="HBH0030649.1"
                     /translation="MKDLGHGANVDEMARLYGKNPKEIIDFSSNINPNVLPNLERYIL
                     KGLEECRNYPDINYTNLRENISKYIDINPDFIIPGNGATEVIYLLMKSIKKKLAIINP
                     TFSEYRRSAELNNLDIIDLELDLENNFKLNIDIIKENIKRFDSLFICNPNNPSGNVQD
                     LKELVHLLDKHNKVLIIDETFMEFVEDESKYSLVKYIESNKNIFIIKAVTKFFGMPGL
                     RLGYGLTSNTEIMNKIYEHKEPWTINSFADILSNFIFEDKEYIKNSKEYYIEEREYML
                     QELRNIRNIKVYDTDANFILIKIYKKTTKELKKDLFKQGNILVRDASNFIGLDDSFIR
                     VAIKSHEDNKILIENMKNLLGD"
     gene            26181..27068
                     /locus_tag="KR257_001946"
     CDS             26181..27068
                     /locus_tag="KR257_001946"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729308.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cobalamin biosynthesis protein"
                     /protein_id="HBH0030650.1"
                     /translation="MKSYGICPASCGEFVQGIIDDEEYLCSYAIDMYSKVYIEEKLVD
                     INLGRYKSRLAIEKVFEKFNLPKKYTKNISLNINSKIPVGKGMASSTADIGATIKATL
                     SLIDKDLSSEEISKLAAEIEPTDSIFIDKNSIFNPLNGTVIKYLGNLTNAKVVILEPN
                     KVLDTMKIRLRQDYNKLKVENKEVIKKSFALLEEGLKKNNLSLVGEACTLSSLANENI
                     EKKEYLNEIIKISKKYGAYGVNIAHSGTVVGILIDKFMNDKKMIDALCESNINSVYNK
                     IYTQNIINGGIKGEIEWNT"
     gene            27056..27688
                     /locus_tag="KR257_001947"
     CDS             27056..27688
                     /locus_tag="KR257_001947"
                     /EC_number="5.4.99.60"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003724727.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cobalt-precorrin-8 methylmutase"
                     /protein_id="HBH0030651.1"
                     /translation="MEYIKNPMKIEEKSFELIQEIIDEIRPDYKFKNNIEEKIIKRAI
                     HTTADFDYLDILKISEEAVDSIIDALKNNASIYTDTNMALSGINKRKLESLGCKYKCL
                     VADDETVKLAKEKGITRSMAAVEIAAKEEGRKIFVLGNAPTALYKVMEMKSEGRLDLD
                     AVIGVPVGFVGAQESKDEVEKTDIPYIISKGRKGGSNLAAAIVNAILYTM"
     gene            27697..28923
                     /locus_tag="KR257_001948"
     CDS             27697..28923
                     /locus_tag="KR257_001948"
                     /EC_number="2.1.1.195"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421296.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cobalt-precorrin-5B (C(1))-methyltransferase"
                     /protein_id="HBH0030652.1"
                     /translation="MEEYVYIDGKKYRRGYTTGSCATGASKAAVYMLITKNRINTINI
                     DTPKGIPLLLKVDNINISDTFVECSIKKDGGDDIDATHTMDIYARAEIVAKNDKNKGY
                     LTLKDIDSLSTNSECKSELYKFIRVYGGTGIGVVTKKGLSVDVGKPAINPTPLKMINH
                     EIRKLIGDNFESILGNDKVLKITIFAPQGETVAKKTFNPRLGIVGGISIIGTTGIVEP
                     MSDDGWKKSLSIELQMKKEQGLDKIILVPGNHGEQFIREKLNLDIKYVVRVSNFIGYM
                     IKEAQRIGYKKILMAGHIGKFIKVSAGIFNTHSKVADARSEILVANLALMGARYEFLN
                     KINQCVTTEEAVELINNSEYREVYNILSNKCRERVKQYLNEDSDDIDVEVIIFSMDKS
                     LLGKSDNTDDLVEVFI"
     gene            28920..29528
                     /locus_tag="KR257_001949"
     CDS             28920..29528
                     /locus_tag="KR257_001949"
                     /EC_number="2.1.1.289"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903759.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cobalt-precorrin-7 (C(5))-methyltransferase"
                     /protein_id="HBH0030653.1"
                     /translation="MINIIGLGPGNLDYITKKGENLISTSDVLIGGKRNLESIKNFEG
                     EKIVLDSNLREIIEYINNNKEKQISIIASGDPLIYGIGRYLSKNIDNKMLNMVSGISS
                     LQYIFSKIYVDMNDVYITSSHGKVPDFDYILSHKKVCMVTDSKIGPKQISREIIDRNL
                     NKIIVVGENLSYDNEKITIAKPEEIIRMDNFDMNVVVILDEE"
     gene            29518..30093
                     /locus_tag="KR257_001950"
     CDS             29518..30093
                     /locus_tag="KR257_001950"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898664.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="decarboxylating cobalt-precorrin-6B
                     (C(15))-methyltransferase"
                     /protein_id="HBH0030654.1"
                     /translation="MRNSEFITGKVPITKEEVRAISISKLNLVNAKNLIDIGAGTGSV
                     SVEAAYNYPNLKVISIEKNDDAIELIEKNKKKFNLKNIEVIKGYAPINLGLNVKVESI
                     FLGGTGNNLEEIIEWSKKNLVTGGRLVANFIIIDTFNQTLKLLKKHGFKEIDVCVLNV
                     SKLEKLGKGEYFKPLNPIYIISCEKGENDDE"
     gene            30086..30838
                     /locus_tag="KR257_001951"
     CDS             30086..30838
                     /locus_tag="KR257_001951"
                     /EC_number="2.1.1.271"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009906481.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cobalt-precorrin-4 methyltransferase"
                     /protein_id="HBH0030655.1"
                     /translation="MNKVHFVGAGPGDKELITLKGYKLLSNADVVIYAGSLVNPELLE
                     YCKEDCQIHNSAHMDLQEIIDVMREGIENNKSVVRLQTGDFSIYGSIREQVEDLNKLN
                     IDYDCTPGVSSFLGAASSLGVEYTVPEISQSVIITRMEGRTPVPEKESIQSYAKHQTS
                     MVIFLSVQEIEKVVSKLLEGGYPKDTPIAVIYKATWADEKIVKGTLSDIAVKVKENNI
                     NKTALIMVGRFLGEEYNNSKLYDKDFKHEYRG"
     gene            30822..31943
                     /gene="cbiG"
                     /locus_tag="KR257_001952"
     CDS             30822..31943
                     /gene="cbiG"
                     /locus_tag="KR257_001952"
                     /EC_number="3.7.1.12"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425735.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cobalt-precorrin 5A hydrolase"
                     /protein_id="HBH0030656.1"
                     /translation="MNIEGNIAIICITENGKKLALKINSLVNNCVIYHVKNKKSNLVV
                     EETCVHTVQKKLSDFVGEIFSKFDYIVFIMATGIVVRSIAPYIISKFSDPAILVMDEK
                     GKNVISLLSGHIGGANSLTQYISSLIDANPVITTATDINQKASLDMIAKKLNAHIDNF
                     RESVKEVNSMLVNNKCVGLYIDEGYQVDTRGFKLIESKDELRDSFSNTYIEKLVVVSN
                     KINCIEDIENLNLDNKFEHCYSTKKIIKVIPRDIVIGIGCRRNTDSELMYNSLEEFLN
                     KQNIDIRAINTVGSIELKKDEKAIIELSKILKVPFKTFSVDEISKVDNLFDKSDFVKK
                     NVGVYSVAEPVAYLLSKGNLLVEKHKYKGITFSVGRIKI"
     gene            31940..32665
                     /gene="cobJ"
                     /locus_tag="KR257_001953"
     CDS             31940..32665
                     /gene="cobJ"
                     /locus_tag="KR257_001953"
                     /EC_number="2.1.1.131"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011701973.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="precorrin-3B C(17)-methyltransferase"
                     /protein_id="HBH0030657.1"
                     /translation="MIYVVGIGPGSKDTMTLEAIKAIEDSEAIVGYKTYIKLIEEFIQ
                     DKEIIQNGMRQEVDRCKQAVEEAKKGKKVAVVSSGDAGIYGMAGLILELISKEDEDIK
                     VKVIPGVTASIGAAAILGAPIMHDFCHISLSDLMTPWEVIEKRLRLAAEADFVICLYN
                     PRSKGRSEHLSKAFKIMGEFKGGDTPVGVVKDVGREKEEKFVCTFENMDFEKVDMTTM
                     VIIGNKSTYINGELMITPRGYTV"
     gene            32662..33414
                     /gene="cobK"
                     /locus_tag="KR257_001954"
     CDS             32662..33414
                     /gene="cobK"
                     /locus_tag="KR257_001954"
                     /EC_number="1.3.1.54"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425730.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="precorrin-6A reductase"
                     /protein_id="HBH0030658.1"
                     /translation="MILILGGTSDSLSICDKINELKNQPYILSVTTDYGRELAQQHAE
                     NVILGKLGKEDMLKFIKDNNIVKIIDATHPYAVEVSKTAITCAKLLNIDYIRFERKSL
                     IEEIDYDNKFIVDTIEEACEIANKIGTNIFIGTGSKNLNRFIEEISDKNLVVRVLPTS
                     EVILSCEKLGLSADNIVAMKGPFSQYINEETYKHYNIDLVITKESGIAGGFLEKVNAC
                     KTFNIPVIIIKRESINYENVFNDINKIKDILV"
     gene            33433..34911
                     /locus_tag="KR257_001955"
     CDS             33433..34911
                     /locus_tag="KR257_001955"
                     /EC_number="2.1.1.151"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891951.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cobalt-factor II C(20)-methyltransferase"
                     /protein_id="HBH0030659.1"
                     /translation="MKKALLVVSFGTSYHETREKTIDICEDKIKNSLKSHDFFRAYTS
                     NMIINKIKKRDGIEIDNPIQALDKIYEQGYDEVIIQTLHIICGEEFNKLKEQVDGYSS
                     KFKKIVLGRPLLTHIEDYQEAVEAIKHQIPHMESNEAVVFMGHGTLHESHSAYPALEY
                     MLRDNGINAYVGTVEGYPEIEHVIRRLKEGNIKTVNLMPFMLVAGDHAINDMAGDEED
                     SWKTILEENGFNVRVHLKGLGENSYIQDKFVRHAVKCAENAKFYGIGAGPGDGSLLTI
                     KAVNTLKKLDILYTPESKKGGDSLALSIVSEYLPESVEIKSRHFPMSFDGNEKSLAWD
                     NVAQEIISDVNDGKNVGFVTLGDPMIYSTYVYIMKRILGEVEVETIPGISSFSNIASN
                     QNFPLVMDKEALVVIPCTMEDDKIEYALQNYNSIVLMKVYKNFKEIIKKLEKYDLIEH
                     AILVSNSSQESENVFTDLKEAHLEDKISYFSTILVNKDNKIK"
     gene            34941..35846
                     /gene="hemC"
                     /locus_tag="KR257_001956"
     CDS             34941..35846
                     /gene="hemC"
                     /locus_tag="KR257_001956"
                     /EC_number="2.5.1.61"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891949.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hydroxymethylbilane synthase"
                     /protein_id="HBH0030660.1"
                     /translation="MNIVVGTRGSNLALIQTEWVINELKKKYPEISFEIKIIKTKGDL
                     IQNVSLDKIGDKGLFVKEIEQQLLDGKIDIAVHSMKDMPSYLADGLKFAHTPKREDPR
                     DVLILREGYKNLDDLPHGAVIGTGSKRRKFQLLKQRPDLNIVQVRGNVETRIRKIKDE
                     NMHGIVLAASGIIRANLQDKISSYLPVDVVIPAPAQGALAIEIRSNDSAIEGIVNSLK
                     DENTEIQILAERGFLDGVNGSCHIPMAAYCEIIQDKIHLTGLYGDSEGKKVVIKSIDG
                     DISSPRELGLKLAKLVLKEYENYEG"
     gene            35836..37335
                     /gene="cobA"
                     /locus_tag="KR257_001957"
     CDS             35836..37335
                     /gene="cobA"
                     /locus_tag="KR257_001957"
                     /EC_number="2.1.1.107"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891947.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="uroporphyrinogen-III C-methyltransferase"
                     /protein_id="HBH0030661.1"
                     /translation="MKGKVYLVGAGPGDYKLMTLKGLECIRKSDVIVYDRLANSSYLR
                     EAKPDCELIYVGKASSNHILPQEDINRIIAEKAKEGKIVTRLKGGDPYVFGRGGEEAE
                     TLVDEGIEFEVVPGITSAIGGLCYAGIPITHRDHASSFHVITGHLKGDDSGELNWNAL
                     ANNKGTLVFLMGISNLEKISENLMKEGKDKDTPVALISWATRYNQRVVTSTLENVYET
                     AIKEEVKPPTLIVVGSVVGLREKLNFFESKPLFGKSIAVTRSRNQNSVLVEKIMDLGG
                     NPIEIPTIKVEKIQNNINLENEIKNINKYNYLILTSKNAVEIFFEKIYEMNFDLRILS
                     NLKVCAIGSATSNELKKRGIIADIVPKKFVAESLYEELAPILNDDDNILIPRAENARD
                     YLVDKLKAICEVTEVHIYRTVIDEEKKGEILDILNSNDIDYITFTSSSTVNNLVEIIG
                     KENIKILEKIKTLSIGPITTETINSLGIKLYKESATSTIDSLVDLIIKN"
     gene            37352..38317
                     /gene="hemB"
                     /locus_tag="KR257_001958"
     CDS             37352..38317
                     /gene="hemB"
                     /locus_tag="KR257_001958"
                     /EC_number="4.2.1.24"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891946.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="porphobilinogen synthase"
                     /protein_id="HBH0030662.1"
                     /translation="MLRRPRRLRASKAIRNLVRETKVNVEDLIYPLFVVEGENIKEEI
                     KSLPDVYHLSIDMLEDEIKEISELGIEHIMLFGVPDEKDECASQAFNDNGIVQKAIRK
                     VKEINSDINVITDVCMCQYTSHGHCGILTDTGYVDNDKSLEYLAKISVSHAKAGADMV
                     APSDMMDGRIQAIREALDENGLENVGIMAYSVKYASNYYGPFREAAHSAPSFGDRKTY
                     QMDPANSNEAIIETELDILEGADILMVKPALSYLDIIRRVKDNFDLPLAAYNVSGEYS
                     MLKFAVKEGLLNEDVILESITSIKRAGADIIITYFAKDIAKLLKK"
     gene            38470..39048
                     /locus_tag="KR257_001959"
     CDS             38470..39048
                     /locus_tag="KR257_001959"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425711.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional precorrin-2
                     dehydrogenase/sirohydrochlorin ferrochelatase"
                     /protein_id="HBH0030663.1"
                     /translation="MLYPINLKLDELDVVIIGGGEVAYRKCKNFLEFNKNVTIVSKQI
                     LNKFYDLKGNIKIIKDDYKEIYIKDASVIIAATNNRELNMEIGLYCKAKNKLVNVVDN
                     IEISNFTVPSYIKRGDLLISVSTGGKSPSLSSKIKKEIEERYTEDYEEYLNVLGDIRK
                     KVIKKYEDKSKRKDVLNMLVTLDLEELKKFDI"
BASE COUNT        15616 a         4114 c         6860 g        12506 t
ORIGIN      
        1 tatctaacta gaacctcagt ttactaatta aattagatgc atagaataac ttttttaaac
       61 attgaaaata aattaaactc taaacacatt taaatataaa tttatatatc attttgactt
      121 ggttaaacaa tttcatactt atcgatataa aaataggtta taatataaat gttcattatc
      181 ttataaccta ttttatataa tttattccta aaacatgtga atgtttttta tgatagtttg
      241 aagaaattat aaaatcactt tataattgaa tattatatat aaattaattt aaatatagaa
      301 aggaaaatat atgtacaaca atatcaaaaa tattttaaaa gaaaatcata taacgtttga
      361 agaatatgac catgaaccta ttttatcatt tgaaaaagct aaagaaataa gagaaaaatt
      421 acaatatact ggagtagaaa gtaaaagttt atttataaaa gataggtctg gaaattacta
      481 tatatttgta accacagaag gaaaaaaatt agatccaaaa actataaaaa atgttttagg
      541 tggaaaagta tctatatgtt caaaagaaga attaacacaa aaaacacaat gtttgcctgg
      601 atgtgtatct ccttttggat atgagaaaaa tatctctctt gtaatagatc aagatatatt
      661 taaccatgat aaaataatct tttcaccagg gataccagaa aagacattta ttattacagc
      721 tagtggattt aaaaaagtaa taaataatat aaacaataca acttataaat atatatatat
      781 taatgaattt taatcataat tgtaaattag agaaaataac attagaaatc atgcttaact
      841 atagtgtaaa taaattatat tcaacacaaa agattgatac tattattaca atagttactg
      901 ttaagctcaa attcaatgta ttatgagtta ttatttttaa attttaatta caaaagcagg
      961 gtagttttaa ctactctgct ttatatttaa cataaaatat ataaaatcaa caaaatgatt
     1021 ttagtctatc tattagatat tcttcgctct caatgcttag aacttttaga tatatacaat
     1081 aagtgctttc atttgtaaaa atttctatag tattatcttg tttatttaca cctacaatat
     1141 ctttaaaatt gatatgattt ttagtatttt tacatttgaa aatatatctg ttatcaatta
     1201 aaatctcatc attagtaatt gaaatatagg gtttatctca tgctttatta aaaatttata
     1261 tgtttgttca agataaaaac ttacaaataa taatagaaaa gttactttaa atgtacatat
     1321 tatcgaaaat attatcacaa aaatacttat aatatatatt tgtttaaaat aacctctatc
     1381 gcaatagttt attaacgata tggaaataaa agtgttaaat cagattttgg agaaataact
     1441 ttaaatattt ccagactctt tttagacagc ctccataacc ttatattgaa cctatttatt
     1501 aactttgtac ttacatatac cacttatata agtttcgtat atattaaagt ccttatctgt
     1561 tactataaaa tctgcctcca taccttgatg tatggagcca caaacattat caatattaca
     1621 acttaaagca gggatatatg tagccatttt tattgcatct tctaaagtgg ctatgttcca
     1681 atcaactata tttctcacag ccttgtccat agttaataca cttccagcta aactcccact
     1741 atttaatctt gcaacactat tttttacatt tacattaaac ttaccaagag tatattttcc
     1801 atcctccata gcaccagctc tcatacaatc tgtaattaaa gctatgttat tactagactt
     1861 agcatccatc attattttaa cagctattgg gcttacatga tgaccatcac aaattaattc
     1921 agcataagta tcttttagta ccatagcagc cccaaccatt ccaggttctc tatgatttaa
     1981 aggactcatc ccattatatg tatgtacaaa cactttagca cctgaattaa cgacttgttt
     2041 aacttgctca aatgtagctg aactatgacc aagagaaact gatatattat ttttagttgc
     2101 atatcttgtt aattctattg aacctttacg ttctggagca attgctattt ttcttattaa
     2161 atttttcgat tttttttgcc ataattttaa tatattgatg tcagggtctt taaaatattt
     2221 ttcattttga gcgcccttat atttttctgt aaaaaatgga ccttctaaat aaatcccttg
     2281 tatttttgca ccctcaactc gattgaagct attgcttata ttttctacag aatcacttag
     2341 tgtatctaca gaatcagtta aagttgtagg taggaaagat gttactccat attttaataa
     2401 gccttttgaa attgtgttta ttgcttcaaa tgtattgtcc atgacatctg cacctaaaag
     2461 accgtgaatg tgagtatcaa ctaagccagg agcaatatat ttacctgaaa aatctataac
     2521 attatcagta acattaggtc tttcttgttg aaattcaccg aatttgccat taattatact
     2581 aaggtaacct ttttctttga ttccatgttt cataaaaaat ttatctgcat aaataaaact
     2641 tttcaaaata acctccttat aattatatta tcattgtggc attgacgctt ataatatcat
     2701 tctgttttct tgaaagttat ttaacttact atcttacatg tcttactcta tatacaaatt
     2761 tatcacttct agcgacactc aaagtaaatt caataactat attgtcatca ttatatgtgg
     2821 tacgaagtaa tttcagacaa ggtgaatctc ctggtacttc caataactta gcttccttat
     2881 ccgagattat tccagctgaa aattcttcat cagcaacttt aataatctcg ccataatctt
     2941 ctctaaatat ttcatataaa ggtttttgtt cgattttttc ttttgtcaat cctataaatt
     3001 ctttcatagg aagatatgtt ctttcaagca tcataggaag gtcatcagca agtcttaaac
     3061 gcattatttt tatcattttt tcaccaggag ttatacctaa tttttcagag aaatactttg
     3121 tactttctac tacctcaaat gataatacct ttgtacctgg cttttttcct tgtgttctca
     3181 tataatctgt aaaactataa ctttccatta agttttgaga attttgactt agtgcagcaa
     3241 caaaagttcc ttttccatgt cttttgtata tatatcccat atgctctaac tcagccatag
     3301 ctagtctaac tgtggttcta cttactccat attcatcaca aatttttctt tcggaaagca
     3361 ttctatcgtt tggttccatc tcattttcaa tcttagttct taatatctca acaagctggt
     3421 catatattgg tcttttatca tttcttttta tcataaaaat atagtccttt ctaagtggtt
     3481 attaccacaa tttgattata gaatatagaa ttatttatgt caatgaataa agtttaatca
     3541 aaattcaata agtaaggcta ttaatttatt ataaaattat ggtacattga caaaacaagt
     3601 aaaataattt atattcaaat tggtaataac cactttggat atattatatg aggtattttt
     3661 tattttacag attaatttat tgtttagaaa agtaaaaatt aataatgagg agaatctagt
     3721 atgattacag taataacatt caacccatct atagatagaa tgtatagagt gaataatata
     3781 aacataggtg aggtgcaaag ggtagtaagt aagaatgcaa ctgctggagg taaaggatta
     3841 aacgtatcta aggtatgtaa aattttaaaa gaaaatcctt tagctatggg atttctaggc
     3901 ggatttaatg gagaatttat aaaaaatgaa cttagaaaac tagatataca aaataaattt
     3961 acaaaaatag agcaggaaac tagaaattgc ttaaacataa ttgaggacaa taaagttagt
     4021 acagaatttt tagaaaaagg accaatagta gaaaaaagcg atttagagag atttgaaaat
     4081 gatatagagg aagtactaaa aaatactaaa atactggtag cttctggtag ttattgtgag
     4141 aatatgccga tagactatta tgaaaagata ggaaatatat gtagagcaaa taatataaag
     4201 tttatattag atacatcagg agaagcatta aaaatagctt taaaatcaaa accatattta
     4261 ataaagccaa atatagatga aataagacat ttattaggaa taaatataga atcaagagag
     4321 gaaattatct tgtcaggaaa aaaacttatt gaaatgggtg cagagaatgt atgtatatct
     4381 ttaggaaaag atggtatggt gtatttaaac gaagataacg tatattatgt aaaagtacca
     4441 gttgtaaagt gtataaatac tgtaggtagt ggagatagca cagtggctgg atttagtgta
     4501 ggtattttaa ggggttataa aatagaaaat ttacttaaat ttgcaaatgc ttgtggtata
     4561 agtaatgctt taaatatgga aactggattt gtagatttgg gagaaattga taaatatcaa
     4621 gatttagttg aagtaaaaaa gttaagttaa atacatttaa tgggaatata ataaatttaa
     4681 tgttgttgta atagatttta attttaatat aaaagatata gtcttatata aaaataggtt
     4741 agaaaaattc atttttaacc tatttttata ataaatatct attttactga atttataatt
     4801 ttctctagta atctttgagc cttgatacac tcttctccac tgatagctgg ttttatatta
     4861 ttttctatac aatcaataaa atgatttgat atatcctcaa aacccttttg ttttaatata
     4921 tttacccatg caccactttg ctttaaagtt aggtttccac cttcttctat ttccagtaca
     4981 ttaagattct taactctttg aatcttaccc tttgaaagaa tttcaacttg ttctaacttt
     5041 gttccagaat ctctatgcat agaggtgttt atagagaaat ttttaccttt aagtttatga
     5101 cttacaaata taagattctt attgtctgtt aaaaataaat cctctccact aatttcaaca
     5161 tcttcatttg ctaaccataa agcagtgtca ataacatgta tatagtcatc tataagagta
     5221 ctgtcgaatt taacatttct taaggaattt aatccatgtt tacatatatt gatagataca
     5281 atttctgtag cattattttt aatttctttg tacataggac agaatctacg gttgaatcca
     5341 accattaaat ttaagttttt tttcgtactt aattcgataa gttcttctcc ttgacttact
     5401 gttgaagcaa gaggtttgtc tacatataca tgaacaccta aatttaataa tatttttata
     5461 atttcgtagt gtgtttctgt agagctatgt agaaaaatac aatcacattt tttagctagg
     5521 gattcaatag aatcgaattg catgattcta taatcactac agactttttc ccttttaact
     5581 ttatttggag taaaagctcc tacaaactca aatctctcag acttagttaa tataggtaaa
     5641 tatgcctttt gagctatgga gccaagacct atcattccca tttttatatt tttcataata
     5701 ctttctccta aggtttttat atttacagaa ttgattataa ttcagacaca taaatttgta
     5761 aactttgtat caaaaaataa atttaaagct tatataagta aattagcgaa ataagaaata
     5821 ttgataaagt aattttgtag gatatctata aaattgattg atataaatat tttatgtatt
     5881 gacaaaaaat tcaaattaat ttatatttgg attagtggta attaccactt tggtctgaac
     5941 aagtttttat cgtaaaataa aaatactaaa gtatatagag tatgatttta ttaaattttt
     6001 aaagataaac tataaaatta attaaaatct atagtgtata ttttatagtg agtttaagta
     6061 gtactaaaaa tctaagcaaa aaattataaa agagtatatt tttttatagt ttaaagtggt
     6121 tataacctca ttaccaaatg taaacgttac aagtatgaaa ggagaatgaa aatgtttaaa
     6181 ttagaagaac aaaaactaaa agatttaggt gcaataataa caactaatga aataaaacaa
     6241 cagcctgaat tatggttaga gacttatgaa atatataaat ctaacaaaga aaaattaagt
     6301 agattcatag atacaataag taataatcat gggcagttta gagttatatt tacaggtgct
     6361 ggaacttcag cttacatagg aaattcaata cttccttacc ttaaaaataa aaatgacata
     6421 agaaaataca tatttgaagc aatacctact acggatatag tttcaaaccc atatgattac
     6481 ttaaaaaaag atataccaac attattaatt tcatttgcaa gaagtggaaa tagtcctgaa
     6541 agtttggctg ctttaaattt agggaataag attgtagata atttttatca tttagctata
     6601 acttgtaatc cagaaggaga actagctaag atgactaaaa acgacgaaaa taattacttg
     6661 ttattaatgc catcaaaatc aaatgatgaa ggctttgcca tgacaggaag tttttcgtgt
     6721 atgatgttat ctgctatgtt aatattcgat agtttagaag atgatgtaga aaagtcatat
     6781 ataaatgcaa tagttgaaat gggaagaaat gttatagata gaaaagatga aatacatgag
     6841 ttaataaata aagattttga tagagttgta tatttaggtt caggaggatt aggtggtttg
     6901 acacaagaag cacaactaaa acttttagaa cttacagcag gaaaaatatc tacagtgtat
     6961 gattctccta tggggtttag acacggacca aaatcattta ttgatgaaaa tacacttgta
     7021 tttgaatttg tatctaactg tttatataca agaaaatatg atttagatgt tttagaggag
     7081 ataaaaaggg ataaaattgc taaattcact tgtgcagtgt cagtagaaaa tgaaaataac
     7141 ttctcaggaa caaagtttga gtttaaagaa aagtataata aattaccaga tgtgtatctt
     7201 gcaatgccat acatattgtt tgcacaaact atagcattgt ttgtatcggt aaaggttgga
     7261 aataagccag atacgccatc agctacagga acagtaaatc gagtagtaaa aggtgtaaca
     7321 atatatgaat attaaaagat aagattaaaa tattataact aaataatttg ggagggtatc
     7381 aatgtggcat tagtaacaac aacatcaatg cttaaaaagg cacaagatga agggtatgca
     7441 gtaggagcat ttaatgtaga aaatatggaa atggtaattg ctgttataga agctgctgag
     7501 gagttaaatt ctccagtaat attacaaact actccatcta ctgtaaaata tgcaggtctt
     7561 gattattatc tagcaaatgc aaaggttgct gcagaaagag taaagatacc tgtagcaatg
     7621 catctggacc atggttcaag ttttgacctt gcaatgaaag ctttaagaag tggatataca
     7681 tcaataatga tagatggttc tcatgaaagc tttgaaaata atatatctat atctaaatca
     7741 gtagtaaaag catgtagtcc ttctcttata ccagtggaag cagaacttgg gaaagttggt
     7801 ggaaaagaag atgatttaga tggcgggaat agtaatgatt atacaaatcc aaaagaggca
     7861 aaagagtttg tcgatagaac aggaatatct tcattggcta ttgctatagg tactgcacat
     7921 ggattgtata agggtgaacc taaaatagat ttagataggt tatcagaaat taaaaatgta
     7981 gtttcaatac ctttagtatt gcatggaggt tcaggaatac atgatgatat tataaaagaa
     8041 gctataaaaa gaggtattgc aaaagttaac tatgcaactg aattaagaat tgcatatagt
     8101 aaaggggtta aaaaagtttt agatgaagat tctgaggtta tagaccctaa aaagtatgga
     8161 ttagcagggc ttcaatcagt aaaggatttt gtgaaagaaa agattaaagt gtgtgggtct
     8221 gtaaatagag tataaaaata aaatatccta aatttatttt agataagttt aggatatttg
     8281 ttatatgaaa aatttatatt aattatatgt aaatggtgta tttttttcat ttaattgatg
     8341 aaaaatatca gcttttattg gtaaagtatt acatatataa ttaaaatata ctaaaaattg
     8401 aactatatat tttattatta taaaatattt atattaaatt gtggaattaa aatatactag
     8461 gatataaaat tcttaaataa aaagaaaaga ttgtttttat aaaaaatatt ttttatacca
     8521 cttaaaaaaa cacaataata acactgaggg aggtggggat atgagagaac gcattattct
     8581 tgaaacatta aaaaatagta gtggttatct aaacatagat tattttgcag ataagttggg
     8641 ggtatctact cgaactatca gaaatgaaat aaaaaagata gaaactataa aagaatgtaa
     8701 tggttttaaa ttagaatata agtctaaatt aggatatatt ctaaatatta aagaccaaga
     8761 taaattcgag cattatctaa gaaacttacc ctcagattta gttgaaaatc cagaacaacg
     8821 gttagagtct ataatagtag aacttttagt aaatgaaggt tataaaacta tagaacagtt
     8881 aagtaaaaaa tttctagtaa gttcatccca aataaaaaat gatttaaaaa agatagatga
     8941 aaagataaag gatacagaat taaaactaga gcgaaaggct cattatggaa ttaaaataga
     9001 aggttctata aaagaaattc aaagtatatt ggtggatagt tattttagag ggaatagaaa
     9061 tataacagag tacaggaata agtttataga taatttaaaa ttagctaata ttagaagtac
     9121 aataaaaaat gtacttaatg aacatgattt agaagcaaat ttaacagaac ttgaggaaat
     9181 attagcacaa attattatat tgtatataag agttagtatg agagtagcgg gaaatgctag
     9241 cgatttaaaa ttatatacag aagatttaat tatagataaa ttattagata aaatttttag
     9301 agataaaaaa tataacctta attatgatga aaagtattat ttaaaggagc ttataaaact
     9361 aaagactaaa gataagaaag ccactataaa gaatattgat aagaataaac ttcaagatat
     9421 tatgttcgaa ttttttagag agatagataa aaaatataac tctaattttt tagaagataa
     9481 agagttcttt aacttatttt acttacatat tgcatgttta atagaacgta taaagaagaa
     9541 ccacaagata ataaatcctt tttcagttaa aataagtcaa cagtatccaa ctgtttttaa
     9601 tttatctatt caattttcaa aaatcataga aaatgagtat catataaaaa taagtcaaga
     9661 tgaaataggg tttatagcta ctcacattgc tgttcctttt gaaaagagag aagaagctaa
     9721 ttttaataaa aaatataaaa tagcaataat atgctcttct ggtggaggta gtgcattttt
     9781 gataaattta agacttaaag aaatttttcc aaatgctgag ataagaaatt tttcattact
     9841 agaagaaaaa gctgtaatag aatttgcacc agatttgatt ttttcaataa caaatctttt
     9901 atttgaaata aatgctccag ttatacttat aaatgaaatt ttagacgaat tggattattt
     9961 agatattaaa gaaagtgtta gatttgcaga ccatatagga aatatatcaa gcccaaaaca
    10021 atatatatta ggtctatttg ataagaatca ctttaggtgt ataaaagata aagctaagta
    10081 taaggatatc cttgatagta tgtcaaaatg tatagttgac gagggcgctt gttctccaac
    10141 ctatcccaaa gatgtatggg aaagagaaag ctatttgagt actatttata caaatggggt
    10201 ggctatacct catccaatcg agatgacagg aaacaaaaat ataatatcag tagctttgat
    10261 acaaactgat attatttatg aaaatagggt gcctaaaatt attttcatga tttcattaat
    10321 aaagggaaat ttagaacttc ataagcaaat atctaaatat ttaagtaaga ttatggcaaa
    10381 taaggatatg gtagacatgc taaataagtc acaatcttat gaagagttta tgtataagtt
    10441 aaaaatctat ctgggaggtt agacatgaat atagagtttt ttaagaggtt gtcagaagca
    10501 gatggtatag catctaatga agaagaggtt agacatgttt tattggaaga actaaaagct
    10561 tatagtgata aaattatctg tgatgggcta gggagtatca tcttttctaa aataaaagat
    10621 gagagtgcac caaacgtaat gatttgtgct catatggatg aagttggatt tatggtgaga
    10681 agtatagaca aacttggtat gattcactta ataacaatag gaggagtaaa acctcttgca
    10741 cagtttgtac aaaaagttag aattacaaca aaagaaggga agaaaatccc tgctgtcata
    10801 aatgctacat ataataatgg taaggctgaa aatatatatg cagatattgg agcatataca
    10861 gaagaagatg tatataacct agggattaat gttggggata tggtaacata tacaacaagc
    10921 tttgaggaat ttactttacc agaccgatta gtgggaaagg cttttgatga taggatagga
    10981 tgttttgtga tgggagaagt tttaaaagaa cttaggaaag aaaatctaaa ttgtaatatt
    11041 cactttgcgg ctacaagtag tgaagaggtt ggaataaggg gagcaaagac atcaacacag
    11101 ttaataaatc cagatatagt atttgtaata gatgtagcat gtgctaaaaa tgagtttgtg
    11161 agagactata caaatcagaa acaaattgat aaaggtgtaa tgctaatgca tagagatagg
    11221 actctagtcc ctagtagaaa aatgatagat tatgtaatgg aaattgctga taaaaataat
    11281 ataccacttc aacatgatat gtttgaatca ggtgggactg atggaggaga agcacatctc
    11341 gtaaatgaag ggaaaccttg tgtagtaact tgtgtaccag ttagatatgg tcattgtgca
    11401 ttttcaatag taagtaataa agatttagag aacattataa gattgtatac acagttaatt
    11461 ttaaattttg atgaagaaca atataaacat ataagaaatt ttatctaaag gagaataaga
    11521 aaatgtcaac agaagtacaa ataatggaac ttatatcaac tgcaggagag agtaaatcga
    11581 aagcttttga ggctttaaaa aaagtgaagt caaaagattt taaaggagca aaattgttaa
    11641 tagaggaggc tcgtaaaata gatattgaag ctcacaggat acaaacagaa ttaataactc
    11701 aagatttaaa tgaagatgtt gaaagtccag caatgagtct tttaatggta catgctcaag
    11761 accactatat gacttctcag ctagcaaaag acttgataga ggctttgata tattgtcttg
    11821 ataagtaatt gtaatataga aatagattat ttatgtaaaa attcttttaa aagtttagat
    11881 gcttttaaga gataataaaa atacaaactt taggaggaat tattatgaaa atattattat
    11941 gttgtgcagg tggattttct actaatatgt taatgcaaaa tatgaaaaag gtggtaaaag
    12001 agagtgctaa actcaatgaa aaagattttg agtttacagc tataccagca gattcaatag
    12061 aaagtgaagt tgatgattgg gatatagtac ttataggtcc tcaaatagct cacaaaatag
    12121 acttcttaaa aggaatatta gagccaaaaa ataagccttt tgcagtaata gataaagatg
    12181 tatatggaaa aatggatgga gctacagtta tgaagttggc attaataact tataagaaac
    12241 atcaattagc tcaaggataa taaaaataat gagggaaaag ggagattaga tatgttttca
    12301 aaatttgaag catttatgaa tagagtattt atgcctttag ctcataaggt tgacaatcaa
    12361 cgtcaccttg gttctataaa ggctggtatg gttgctatga caccattcac aatattagga
    12421 agtatatttg caatacttcc agcacttcca aatatgcttg gagaaaataa tccaataagc
    12481 aaattcatac ttaacaattc agcaatattg gatttaccag taagtctttc cataggttta
    12541 ataggattat atgcttgtat gtgtattgct tttaatctgg ggaactacta taaattatat
    12601 ataccaggtt gtgttgcact atcaactttt tcttttttat tcctagtagc atcatttaca
    12661 ccagatggag ctttagaaat aggaaattta ggagctaaag ggctatttac aggtatgata
    12721 gcagggcttg gttctgtgga gttatataat ttttgtaata agaagaatat cacaataaaa
    12781 atgccagaaa atgtacctga ttttgtatct aggtcttttg aattaatacc tactactata
    12841 atagtttgtg gaacttttat agttgctcgt tttatttcat taaaagtatt tggagaatta
    12901 cctccacaga tacttactca atttttatct ccattagtag gaagtatgga taacccatgg
    12961 tcagttcttg cacttaactt tgctatatgt actatattct tttttggaat acattcatca
    13021 gtatttagtc ctataactag acctataatg attacattta tagctgaaaa catagcagct
    13081 atgcaagctg gagaaacaat acctcatttc tttacagcag gagcttcaag tgcattcttt
    13141 ggatttacag gatgtggaat tagtataggt tgtgtaattg catgtatgtt atcaaaaaat
    13201 gcttcctata agaagattgg acgtgtatca ttattccctg cattatttgg gataaatgaa
    13261 ccaatattat ttggagcacc gataatatta aatccaataa tgtttatacc acatgtattt
    13321 ggtggagcta taataggtac actaccaatg ttttttatgc actggggatg gttagcaaag
    13381 ccagtatttg accctccata tgtaggggta ttcttagaag gatttttaac taatggagat
    13441 tggcattcta tattagcaaa tgcattgcaa ttagtattag cagttttatt atattggcca
    13501 ttctttaaaa taatggaacg tcaacaaaat aataaaaaac aaaaagaaga aactaagaat
    13561 atattctcta aagaagaaga agacttattg gatgatttag gattggattt ctaatatttt
    13621 gttatgaata atacaatgga gagattagta tccttaatct ataaaagagg tgttgacgct
    13681 cttttgatta aagcaaaaaa tactaaaaga tatataggag ctttatcagg tagtggtgta
    13741 tatgtgcttg ttactaagga taaaaattat caaattctag atggcagata tattgatgaa
    13801 gcagataaaa aaacgactgg tttcataaaa aggattgtat ctcaaggttc ttatatacca
    13861 actataattg agttattaaa agaattaaat ataaaaaagt tagcaataga aaaccaagct
    13921 atgagtatac aagagtatct ttcactaaaa aatgaaggtt ttgaaatcaa tttaataaca
    13981 aatgaattat ggaagctaag ggctataaaa tctaaagaag aaattgaact tattaaaaag
    14041 gcttgtgaaa ttacagatga agtatttgat gaggttattt ctgaaattaa aaaagatatg
    14101 actgagctag aagtatcagc tctaattcag tatcatgcat taaaaaaagg tgcaagtgga
    14161 atgtcttttg aaacaatagt ggtatcagga gaaagaggtg caatgccaca tggaagacct
    14221 acaaacaaaa aattgaaagt gaatgaagct ataacaatag attttggtgt tgtttatcaa
    14281 gggtatcaat cagacatgac tcgtacaata tctataggta aacctcctaa aattattaaa
    14341 gagatatatg atgtagtatt ggaagcacaa ttatctgcaa tagagtcaat aaaggaagga
    14401 actagggcaa gtgatgttga caaagtggct agaaaaatta tagataaaca tggatttggc
    14461 gaatatttta atcatggact gggtcatggt ataggtcttg gagatggtga agtccccact
    14521 ttaaatccaa atagtgaaga tatattagtg gaaggaatgg taatgtcttg tgagccaggt
    14581 atttatattc caaatgtagg gggagttaga atagaagatg acattgttat aatagatgga
    14641 aaaggtgttc cactcaataa gacatccaaa gagtttataa tattaggaga gtaaaattat
    14701 gaaatataat tttaataaag tattaaatcg taaagaagga aattgtagaa aatggagcaa
    14761 ccatgtgatt aaagaaaaat tcggcttaaa tgaagatgca attcctatgg atttagctga
    14821 tatcgatttt gagtgtgctc ctgctataaa agaatctatc ttaaaaagag catcagtagg
    14881 agattatagt tatactttta taggagatga cttctatgat gcgattataa attggaataa
    14941 aagaagattt gatgtatata tagaaaagga ttggataaaa ttaacttttg gtactgtttc
    15001 aacccttcat tatatagtcc aagcatatac taaagaagga gagggtgtat tgataaatac
    15061 acctgcttat gacccttttg cagaggctgt agtaaataat aatagaaagt tgtgttgtag
    15121 ctcattaaaa ttagataaca atagatatta tttagattta gaggatatgg aaaatcaaat
    15181 gaaatacgag aatataagat tgcttatatt ctgtagtcca caaaatccat caggtcgtat
    15241 atggacaaaa gaagaactat atcaagtgtc agagttatgt ttaaagtata atgtaatttt
    15301 ggtaagtgat gaaattcata gagatataat atttaaagat tatagatttg tatctttatg
    15361 gaatgctcat ccagaaattt ataaaaatag tataatctgt gtatctccta ataaaggctt
    15421 caacttaggt ggattaaaaa catcatatgt attaataaga gatgtaaaaa ttagggagac
    15481 tttattagaa agactaaaaa gtaattcaat aacttctcca aatgtatttg caataccagc
    15541 aatagttgca gcatataatg aaagcgaaga atggctagat gctatgacta gttatgtaga
    15601 ggagaatttt gaaatagttt atgatttctt tgaaactaat ataccaaaag ctaaagtgat
    15661 gaagtcagac tcttcttttt tagcctggat agatgtaaga gaagtattta gaaatgaaga
    15721 agaatctaaa gaatttttta gacatgcaaa cttaactatg gtagttggaa gttattttgt
    15781 gaaagatgga gatggattta ttcgtattaa tgtggggtgt cctagagaaa cattaaatga
    15841 ggctctaaat agaatcaaaa aaacgtatat aagtatgtat tgttaaatca taaaaaaagt
    15901 atctatggtt tatataaaaa cacattattt agttatcaaa tattactgga attttgtatt
    15961 ccagtaatat tttttgatta aggaatatta ttgaggaata ttaaataata ttatttcata
    16021 cccttatatt aacttatata aaaatatttt attattttgg gaacgggtta gctaaccttt
    16081 atctagtgta tatttatatt gtaagaagca gtaaaaactt ttcctttact aagtttatta
    16141 ataaacttct tatctttata aattttgtta gaatttatac tatcagcaag accataccaa
    16201 ggttctatac ataaaaaagg agcagtagaa ttagtttcac tataataagg agtccaaata
    16261 ccaactagag ggaaatcttc catagatata gttacatatt tactaccatc attattacat
    16321 atagatactt catctatgtt ggtgtatatc aaagcatcat tcttgaatac ttctggattt
    16381 aactgtaagt tttttaattt tccaataggt attatatcat ctgtaaaaga accatttaaa
    16441 ttgatttttt ctacatcatt tttactttta aactcaaggt agtgtttaga aaaatcattt
    16501 tgttcgtaaa aaggaaggtt gaatgcagga tgtccaccta tagaaaagaa tatatcttta
    16561 gaatcagtat tttttacaat ccattctacc tcaatactat tatcatttaa tgtatagttt
    16621 atgattagct caaaagaata tggatacttc tttaaagtag attcattatc tgttaattta
    16681 taagttacaa atgtatctcc tttatctaca atctcaaagt ccatatctct agcaaaccca
    16741 tgttgagtca tgctatataa attttcttct attattgttt cattatcaaa aagtttacct
    16801 actataggga acaatatagg tgattgtcta ccccaatatt ttttattacc atcccaaaga
    16861 atgtttttgt cgtatttttt agaaaatatt ttagttagtt cagcaccaaa actgcttgat
    16921 tcgataatta aattttcatt ttgtaatata ttcatttaaa atctccttta ttatatttta
    16981 tgagtatatt atactataaa gtataaagat tattaaattt tatttgatat tatatttgaa
    17041 aggtagattt tagtatattt tgaaaatttt gttttgaaaa tttgggatta tttaagaaat
    17101 tttgtattat aaatagaagg aaatagataa attgtataga ataaaatata ttaagataag
    17161 ttaataatgt taaatgggaa gtgagtttat ggaaaaacca aatacaaaag ttgttaactt
    17221 tcaagagtat aaagacagaa aaaaccaaag agaagtaaat agagacgaac ttttaaagct
    17281 tataaaaaaa attgtgactt caaaataggg agttgttaaa ctccctattt taatgggttt
    17341 cataataatt aagacattct gagtccatct atataatctt tgaattgtga gaaatctgat
    17401 tcactactta attctatggt ttctgaacct tccgtataaa aattcttaag atagatagta
    17461 taattattat caacacaatc atgataaata catctatatc catcttcata caaacttttt
    17521 aacttagaaa aatcatccac aatatcatct ccttaaagtt cttttaaata tatttttaca
    17581 aaaagcatct aattgtatgc aaattgacaa tgtaaaataa aggaaatgaa cataaaatgt
    17641 agaataattt ttatatgtat gtaaaaataa aaagaaaaag ttgaaatttt tagaaaataa
    17701 gagtattttt tatctaaaaa gagagtttaa aaaataaaaa aatgttggga ggataaaaaa
    17761 tgagtttatt agaaagtata tcaaaaaaca tatattccct agataactct tctattgaaa
    17821 aaacaaagca gagattggat aggcttatac atccaactgg aagcttagga aagatagaag
    17881 atatttgcat gcaattagca ggaatatttg gcaatgaaaa ttttgacaca agtaaaaagg
    17941 ttataattgc ttttgcggga gaccatggtg tatatgaaga aggcgtagca cctgaccctc
    18001 aaaatataac aaaattacag tttccaaatt tttcgaaagg tctatgtgga gttggagtaa
    18061 taagtaaatt tgtaggggca gatgttgtag ctgtagatgt aggaataaac tgtgatgaaa
    18121 aactggatgg ggtattagac tacaagataa gaaaagggac atcaaatatg gcaaaaggtc
    18181 cagctatgag taaacaagaa gcaattagat gtttagagat aggtattgaa atagcagagc
    18241 agtgtataga aaaagattat aaggttattg gtattgggga gatgggtata gcaaatacta
    18301 ctccaagtac agcaataata tctgtaattt cagggtgtga cccgttagaa gttactggta
    18361 taggtgcagg tcttaagaaa gaaagactaa agcataaggc tgaagtaatt agaaaggcta
    18421 ttgaaattaa taatccaaat ccaactgatg gagtagatat tttatctaaa gtaggagggt
    18481 ttgaaatagg ctcaatggca ggtgttatat taggttgtag tgctaatagg attccagtag
    18541 taattgatgg gtttatttct tatgcagcag cattaattgc atataagata aatccaaaaa
    18601 ctagagaata tatgatagca tctcatttat cagcagaatc aggaactaaa agagcattag
    18661 acatattaaa attagaccct ctattaaata tggatatgag attaggtgag ggaagtggag
    18721 ctgctttagc atttgatata atagaagctt caaactatac ttataaaaat atggcaactt
    18781 ttgatgaaat tgacatggga agataaatat aaaaatttaa tatgtaggag tgttttgatg
    18841 agtaaaatta ttctagtaac aggaggagct aggtcaggga agagtaactt tgcagaaaaa
    18901 ctatgttttg acagaaataa taatacagct tatatagcaa cctctattcc atttgatgat
    18961 gaaatgaaag atagagtaaa aaaacatcaa gagaatagac ctagaaactg gaatacttat
    19021 gaaatatatg aagatatata ttccataatt aaggagatat ataaagaaca tgaaactgtt
    19081 atactagatt gtgtaacatt attagtaaat aatctaatgt ttgaacacaa tctaaatata
    19141 gaagaatcta gtcaagaaga aataaacaaa ttagaacaat acataaaaga acaagttgtc
    19201 aaacttattg aagaaataga aaaaacaaat ctatactttg tatttgtaac gaatgagtta
    19261 ggtatgggaa ttgttcctgg gaataaactt agtagaattt atgctgatat tgtaggtcgt
    19321 ataaatcaat atatagcttc gaaaagtaat gaagtttatt ttgtagttag tggcatagct
    19381 atgaagataa aggagtagta tgcaattatg aaaagattta ttttaatact acagtttttg
    19441 acaaggatac ctataaaatt aaatgtagga tttgatgatg aattttataa gtcaatagta
    19501 tattttccac ttgtaggttt tgtcataggt atattatcct atttaatagg atggatttct
    19561 atgcttttat ttgaaccatt tatagcttct ataataataa ctctagctgg tgtcttaatt
    19621 actggaggac ttcatataga tggattagga gatacatttg atgcaatata tagttatagg
    19681 gataaagaaa agatgcttga aataatgaaa gattcaagat taggtacaaa ttcacttcta
    19741 gcaattatgt ttgtactttt attaaaggtt ggattcgttt acgatataat aagtaataat
    19801 tcattgtggg ttataatttt tatgccaatg attgcaaggt taggagtaat gttattgaca
    19861 tataaaactg tgacaccaag agaaaaagga atgggaaatt tatttatagg aaaattaact
    19921 acaagtatgt taataactgc tataatatac acattattga tagttgctct tattactaaa
    19981 tttatatttt tattacctaa tatagtgttg attaaagtat taggttcgat tatagtggtt
    20041 tttgtattta taatattatt caaaaaacat atttataaaa aaattgacgg agtaacagga
    20101 gatatattag gctgtggaat agaactttca gagcttgtat atttaattta catatatttg
    20161 ttaattttta tgttttttta aagtaaaaag tggtgataat atgataagat taatattaat
    20221 aagacatgca ctgacaaatg ataataaaaa aggaagatta tcaggccata taaatagttg
    20281 tattagtgaa gagggcaaac tacaaataaa taaaattacc agatatctga gtaatgaaaa
    20341 catagataag gtttatacaa caccatctac acgtactaaa gatacagtag aaaaaatatc
    20401 aaaattgaaa ttattagaaa tagaagaaaa agaagcttta agagaaatta gttttggaga
    20461 ctttgaagga agaacttttg aagaaattaa aatcaaatat ccaaatgagt ttgaaaaaat
    20521 gataaaagaa ggtaacaact atagatatcc aaatggagaa agtttgatag actcttataa
    20581 aagagtggca aaagaaattg ataatataat tttagaaaat gatagtaatt tagatacaaa
    20641 gacaatactt atatgttctc atgcaggaac aataagaaat ataataacac atttgatttc
    20701 tggtagttat aagtatcact ggaactttaa aattgataat gcatctatta cagttttaga
    20761 aattgatggt ggatttgctg taatagataa aatgaatttt acagacttca tataatttaa
    20821 tcaaaaccaa acattacaat ctgtgtttgt aatatatctg taaaattagc aatgaaaata
    20881 gaatattaga ttaaaattag gttcttaatt agatgttaaa agggaaaaag gttagatgcc
    20941 tttgcagccc ccgctactgt gaaaccaacg aaactataaa taccactgtc agtttgatgg
    21001 gaaggttata gaagtaggat gaagttaagc caggatacct gcctaattta atttaaaaca
    21061 agaggtcttc ggggtgaaag atttttaatt aatatatata aaagtcctat ctttagaagt
    21121 attaggactt tttttaattt gttttttagt aaattttaac aaggagggat ggaaagtggg
    21181 gaaaaaaata atgctacaag gaacagcttc aaatgtaggt aaaagtgtct tagtagcagg
    21241 tttgtgtaga atatttaagc aagatggtta tactgttgct ccttttaagt cacaaaatat
    21301 ggctttaaat tcttttataa ctaaagaagg attagaaatg ggaagagcac aagtatttca
    21361 agcagaggct gcgaaaatag agccaatagc tgatatgaat ccagttttat taaaaccttc
    21421 tggaaataat aaaagtcaag ttattgtaag aggtaaagtt gtaggagaaa tgccttcttc
    21481 taagtatcat gattataaat tggagttagt agatgtgttg aaggaaacat ttaatagctt
    21541 aaattcaagg tatgatattg tagttatgga aggggcagga agtaatgcag agataaactt
    21601 aaaagataga gatatctcta atatgggtat ggcagaaata gctgatgcac ctgtaataat
    21661 agtcggagat attgatagag gaggcgtatt tgcctcatta gcaggaacaa tgcttttatt
    21721 aaatgaagat gagaaaagaa gagtaaaagg tgtaataatc aataaattca gaggaaaaaa
    21781 agagctttta caagatggtg taaagatgct agaagacatc ataaaagtac ctgttatagg
    21841 agtagtacct tatacagata taaagataga agatgaagac agtgtaacta cgagatttaa
    21901 gaaaaaaatg aataaaagtg atatacacat agaaataatt agaactccac atatgtcaaa
    21961 ttttacagat tttaatatat ttgagacaca agaagatgta agtattagat atgtagacta
    22021 tggagaatct ttaggaaatc cagatatatt aataatacct ggaactaaaa gtactataga
    22081 cgatttaaca tatataagaa aaagtggtct tgaatcgcaa atcaaaaatt tacatagtca
    22141 aggtaaattg atatttggga tatgtggtgg ataccaaatg ttaggtaaaa aattaaaaga
    22201 cccttatcat gttgaaagtg aaattgaaga agttgatgga ataggtcttt tagatacaga
    22261 aacaacgttt gagaaagaaa agactacaac acaagtagaa gctactattg ttgaatgtat
    22321 tagtgaatac atgaataacc ttaagggaaa aaaagtaaaa ggttatgaaa ttcatatggg
    22381 aattacaaag cgaggtaatg atgtaagaag tttagattta ataactaaaa aacttgataa
    22441 agaagtgaat tatactgagg gaagtgtaaa taaagagggg aatgtaattg ggacttatct
    22501 tcatggaata tttgatgaaa taagctttac aagagcaatt ttaaacaata taagaaagaa
    22561 aaaaggttta ggagaattag aaagcaaagt aaactctttt aatgaattta aggataaaga
    22621 gtatgataag ttggctgatt ttttaagaga acatttagat atagagaaaa tatatgagat
    22681 tatgaaataa tgatgacctt tatttataat ttaggtagga ggtgtattat gaaaaaaatt
    22741 ttaattgcgg gtactaatag tggagtaggt aaaacaacaa tatcattagg aataatgcaa
    22801 gctttggtta agagaaatat gaaagtacag ccatataaag tagggccaga ctatatagac
    22861 ccttcatatc acacttttat aactggaaga cattctagaa atttagattc ttatatgtta
    22921 gatgatgaaa aaataaagta tatagtaaat aagtcctcaa aagatgcaga tatttcagta
    22981 atagaaggtg ttatgggctt atatgatggc tttggaatag atttagataa ttgtacaagt
    23041 tcacatactt caaaggtatt aaagtcacct gttatattag ttataaatgg taaatctatg
    23101 gcagcatcta gtgctgctat ggtacttgga tataaggaac tagataaaga tgtaaatata
    23161 aagggtgtta tagtaaataa tgtaaagact aatagccatt atcaaataat taagagttct
    23221 atagaaaaat attgtaatgt tgaagtattg gggtattttc ctccaaataa caaattctct
    23281 ttggaatctc gacatctagg attagttcct agtgtagaaa tgaaatcact aagggaaaaa
    23341 ttttatacct tagcagatga aattgaacac tatatagata ttgacagaat aattgaaata
    23401 tcagaaagcg atgaatttga gagtgatttt gattttcaaa ctttaataga aaataataaa
    23461 ataaaagaac atgttaataa taaatcaata gctatagcat atgataaagc attcaatttt
    23521 tattatagag aaaatataga gcttttagag gaacttggtt tagaaataaa ctattttagc
    23581 cctcttgaag atgtatcagt gccaaatgca gattatattt atattggagg aggttttcca
    23641 gaaatatttg gaaaagaatt agaagcaaat gagtcaatga gaacttccat attagaagca
    23701 cataacaata atatacctat ttatgcagaa tgtggaggac tgatgtacct aggtgagaaa
    23761 ctattgaatc aagaagaaca agaatttaat atggttggaa tatttagtgg aattagtaag
    23821 atgacatctt ctttaaaaag atttgggtac tgtattggtg tagccaagga aaatactctt
    23881 ttatctaaaa aaggggaatc tattaaaggg catgagtttc atcattcaat atttgaaagt
    23941 gatgaaaaat gtgtatattc aatgagaaaa gaaagagatg gaaatatagt agaagagtgg
    24001 gatggtggtt atagtaaagg aaacactttg gctacatatc ttcatactca tttttataat
    24061 aacttaaatt gtatagaaaa ttttttgaaa aaaggaaatg aataaatgag tattttatct
    24121 atttatatag gatatgtgac agacttaatt gtaggagacc catattcttt tcctcatcca
    24181 gtgagattta ttggtaaact tataaatttt actcaaggta taataagaaa ggtctctaaa
    24241 aatgataggc agttaaaatt ggggggattt atattatggt ttataaccgt tggaataaca
    24301 tatttaacaa cttatgctat agtgaagtta tttagtttta atatattatt gagtattgta
    24361 gtgaatagtt ttataattta tacaacacta gccacaaaat gtttaaaaga cgaagcatta
    24421 aaaatttata atgtattaaa aactgaagat atagaaaaat ctaggattca gctatcttat
    24481 atagtaggta gggatactac taatttaagt gaacctgaaa taataagagc aactgtagaa
    24541 actgttgcag aaaatactgt agatggtata attgcgccta tgttttatgc atttattgga
    24601 ggagcaccac ttgctatggc ctataaagct atcaatacat tggactcaac agttggatat
    24661 aaaaataaaa agtataaaga tattggtttt gcatctgcta agattgatga tatagccaat
    24721 tatataccag ctagaatatc tgtcattctt atgacaattg gaagtttctt tttaaattat
    24781 aactatagga actgttttaa aatctctatt agagatagaa agaatcataa aagtccaaat
    24841 tgtgcttttt cagaaggtgc agtatctggt gctctaggaa tacaactagg aggtaccaac
    24901 gtttattttg gggaaaaagt atataagcca acaatagggg ataagcttag ggagatagat
    24961 aaagaagata taattaaaac taataaaatt atgtatgcat cttcatttgt atctatgttg
    25021 gtatttacac taatatatgt gttatgtagg atgattttaa ttaacttaat tatataaatt
    25081 attgtttgtt aacttaaggg ggacatagat gaaggattta gggcatggtg ccaatgtaga
    25141 tgaaatggca agattatatg ggaaaaaccc aaaagaaata attgatttta gttcaaacat
    25201 aaatccaaat gtattaccaa atttagagag atacatttta aaaggattag aagagtgtag
    25261 gaattatcca gatataaatt atacaaactt gagagaaaat atatcaaaat atatagatat
    25321 aaatccagac tttataatac ctggcaatgg tgcaacagaa gtgatttatt tgcttatgaa
    25381 gagtattaaa aaaaaattgg ctataataaa tccgactttt tcagagtata gaagaagtgc
    25441 tgagttaaat aatttagata ttatagattt agagttagat ttagaaaata actttaaact
    25501 taatatagat ataataaaag aaaatataaa aagatttgat agtttattta tatgtaatcc
    25561 taataatccg agtggtaatg tccaagattt aaaggaactt gttcatttac tagataaaca
    25621 taataaggta ttaataattg atgaaacttt catggaattt gttgaagatg aaagtaaata
    25681 tagtttggtt aaatatatag aatcaaataa aaatatattt ataattaaag ctgtgactaa
    25741 gttttttggt atgcctggtt taaggctagg atatggtctt acaagcaaca ctgaaattat
    25801 gaacaaaatt tatgaacaca aagagccatg gactatcaat tcttttgcag atatactatc
    25861 caattttatt tttgaagata aagagtatat taaaaatagt aaagaatatt acatagaaga
    25921 aagagaatat atgttacaag agttgagaaa cataagaaat ataaaggtct atgatacaga
    25981 tgctaatttt atcttgataa aaatatataa aaaaacaact aaagaattga aaaaagattt
    26041 gtttaagcaa ggaaacatat tagttagaga tgcgtctaat tttataggat tagatgatag
    26101 ttttataaga gtggctataa aatctcatga agataacaaa attcttatag aaaatatgaa
    26161 aaatttattg ggtgattaaa atgaaatctt atggaatatg cccagcatct tgtggagaat
    26221 ttgtacaagg tataattgat gatgaagaat atttatgttc atatgcaata gatatgtatt
    26281 ctaaagtgta tattgaagaa aaattagtag atataaattt agggagatat aagtcaaggt
    26341 tagcaattga aaaggtattt gaaaaattta atttacctaa aaaatatact aaaaatattt
    26401 ctttaaatat aaatagtaaa atacctgttg gaaaaggaat ggcaagttca actgctgata
    26461 taggagctac tataaaggca acattatcat tgatagataa agatttaagt agcgaggaga
    26521 tttctaaatt agcagcagaa atagaaccaa cagattctat atttatagat aaaaatagta
    26581 tatttaatcc tctaaatgga actgttataa aatacctagg aaatctgacc aatgcgaaag
    26641 ttgtaatact tgaaccaaac aaagtactag atactatgaa aattagattg aggcaagatt
    26701 ataataaatt aaaagtagag aataaagaag taataaaaaa atcatttgct cttttagaag
    26761 aaggattgaa aaaaaataat ttatctctag ttggagaggc ttgtactttg agtagcttag
    26821 caaatgagaa tatagaaaaa aaagagtatt taaatgaaat aataaaaata tcaaaaaaat
    26881 atggagcata tggagtaaat attgctcaca gtggaactgt agtaggtatt ttaattgata
    26941 agtttatgaa tgataaaaag atgatagatg ccttatgtga atctaacata aattctgtct
    27001 ataataaaat ttatacacaa aacataatta atggaggaat taagggggaa atagaatgga
    27061 atacataaag aatcctatga aaatagaaga aaaaagtttt gaattgatac aagaaataat
    27121 agacgaaatt agaccagatt ataaatttaa gaataatatc gaagaaaaaa taataaaaag
    27181 agctatacat actactgctg attttgatta cttagatata ttaaaaatat cagaagaagc
    27241 agttgatagt ataatagatg cattaaaaaa taatgcaagt atttatactg atacaaatat
    27301 ggctcttagt ggtataaata aaagaaagtt agaatcatta ggatgtaagt ataaatgttt
    27361 agtggcagat gatgaaactg taaaattagc taaagaaaaa ggaattactc gttctatggc
    27421 agcagtagaa attgcagcta aagaagaagg aagaaaaata ttcgttttag gtaatgctcc
    27481 aacagcttta tataaagtta tggagatgaa atcagaaggt agattagatt tagatgcagt
    27541 tataggagtt cctgtaggtt ttgtaggagc acaagaatca aaagatgaag ttgaaaaaac
    27601 agatatacca tatataattt ctaaaggtag aaaaggtggc agtaatttag cagcagcaat
    27661 agtaaatgct atattatata ctatgtaggt acctatatgg aagaatatgt atatatagat
    27721 ggaaaaaaat atagaagagg atatactaca ggttcatgtg caacaggtgc atctaaggct
    27781 gctgtatata tgttgattac aaaaaataga attaatacta taaatataga tactcctaag
    27841 gggataccat tactactaaa agttgataat ataaatattt ctgatacatt tgtggaatgt
    27901 tccataaaaa aagatggtgg agatgatata gatgcaactc ataccatgga tatttatgca
    27961 agagctgaaa ttgtagctaa aaatgataag aacaaagggt atcttactct aaaggatata
    28021 gatagtttaa gcaccaatag tgagtgtaaa agtgagctct ataagtttat tagggtttat
    28081 ggcggaactg gtattggtgt ggttacgaaa aaagggctta gtgtggatgt tggtaagcct
    28141 gctataaatc cgactccact taaaatgata aatcatgaaa taagaaagct tataggagat
    28201 aattttgaat ctatacttgg aaatgataaa gttttaaaaa taacaatctt tgctccacaa
    28261 ggagaaactg tagcaaaaaa aacatttaat ccaagattag gtatagttgg aggaatatct
    28321 ataataggta caactgggat tgttgaaccc atgagtgatg atggttggaa gaagtctcta
    28381 tctatagaac ttcagatgaa aaaagaacaa ggcttagata aaataatatt ggttccagga
    28441 aatcatggag aacagtttat aagagaaaaa ttaaacttag atattaagta tgtagttagg
    28501 gtaagtaatt ttataggcta tatgattaaa gaagctcaaa gaataggata taaaaaaatc
    28561 ttaatggcag gccatatagg taaatttata aaagtatctg ctggtatttt taatactcat
    28621 agtaaggtag cagatgctag aagtgagata ttagtggcaa acttagcttt aatgggagct
    28681 agatacgaat ttttaaataa aataaatcaa tgcgtaacta ctgaagaagc tgtagagcta
    28741 ataaataata gtgaatatag agaagtatat aatatattaa gtaataaatg tagggagaga
    28801 gtaaagcaat acttgaatga agattcagat gatattgatg tggaagtaat catattttca
    28861 atggataagt ctttattagg taaatcggat aatacagatg atttagtgga ggtctttata
    28921 tgataaacat aataggtcta ggacctggta acttagacta tataacaaaa aaaggtgaaa
    28981 atttaatttc cacttctgat gtattaattg gtggtaaaag aaatttagag tctataaaaa
    29041 attttgaagg agaaaaaata gttctggatt ctaatttaag agaaattata gagtacataa
    29101 ataacaataa agaaaagcaa atatcaataa tagcatctgg ggacccatta atatatggga
    29161 taggtagata tctatctaaa aatattgata ataagatgtt aaacatggtt tctgggatta
    29221 gttcattaca gtacatattt tcaaaaatat atgtagatat gaatgatgta tatattacaa
    29281 gtagtcatgg caaagtacca gattttgatt acatattatc acataaaaaa gtatgtatgg
    29341 ttacagattc aaagatagga ccaaaacaaa taagtagaga aataatagat agaaatctaa
    29401 ataaaattat tgttgtagga gaaaatctgt catatgacaa tgaaaaaata acaatagcaa
    29461 aaccagaaga gataataaga atggacaatt ttgatatgaa tgttgtggtg attttagatg
    29521 aggaatagtg aatttataac aggtaaagtt ccaattacta aggaagaggt tagagcaata
    29581 tcaataagta agttaaattt agtaaatgct aaaaacctca tagacatagg ggctggtaca
    29641 ggaagtgtaa gtgttgaagc tgcatataat tatcctaatt taaaggttat atctatagag
    29701 aaaaatgatg atgctataga gcttatagag aaaaataaaa aaaaattcaa cttaaaaaat
    29761 atagaagtga taaaaggata tgctccaatt aatctagggt taaatgttaa agttgagtct
    29821 atttttcttg ggggaacagg aaataatctg gaagaaataa tagaatggtc taaaaaaaat
    29881 ctcgttacag gaggaagact tgtagctaat tttataataa tagatacatt taatcaaact
    29941 ttaaaactgc ttaaaaagca tggatttaaa gaaatagatg tatgtgtttt gaatgtttct
    30001 aaactagaga aactaggaaa aggtgaatat tttaaaccac taaatcctat atatataata
    30061 tcttgtgaaa aaggggaaaa tgatgatgaa taaagtacat tttgtaggag caggacctgg
    30121 agataaagag ctgataacat taaaaggata caaattatta agtaatgcag atgtagtgat
    30181 atatgcaggt tcacttgtta atcctgaact tttggaatac tgtaaagaag attgccaaat
    30241 acataatagt gcacatatgg atttacaaga gataatagat gttatgagag aaggtataga
    30301 aaataataaa tctgttgtaa gactgcaaac aggtgatttt tctatatatg gttcaattag
    30361 agaacaagtg gaagatttaa ataaattgaa tatagattat gactgtactc caggagtaag
    30421 ttctttttta ggggcagcat catctttagg ggttgaatat acagttccag aaatttctca
    30481 aagtgtaatt ataacaagaa tggaaggcag aactccggtt ccagagaaag aatcaataca
    30541 atcatatgct aagcatcaga catctatggt aatattttta tctgttcaag aaattgagaa
    30601 agttgtgtct aaattactgg aaggtggata tccaaaagat actcctatag cagttatata
    30661 caaagcaact tgggcagatg aaaaaatagt taaaggaact ttaagtgata tagctgtaaa
    30721 agttaaagaa aacaacataa ataagactgc tttaataatg gttgggagat ttttaggaga
    30781 agagtataat aattcaaagt tatatgataa ggatttcaaa catgaatata gagggtaata
    30841 ttgctataat ctgtattaca gaaaatggaa aaaaattagc tctaaagata aattctctag
    30901 taaataactg tgttatatat catgtaaaaa ataaaaaaag taatttagtt gttgaagaaa
    30961 catgtgtgca tacagttcaa aagaagttaa gtgattttgt aggagaaata tttagcaaat
    31021 ttgattacat agtatttata atggctacag gtatagttgt acgaagtata gcaccataca
    31081 taataagtaa gtttagtgac cctgcaattt tggtaatgga tgaaaaaggc aaaaacgtaa
    31141 taagtttatt gagtggtcat attggagggg caaacagctt gacacagtac ataagtagtc
    31201 ttattgatgc taatccagta ataacaacag ctactgatat aaatcaaaaa gcttccttag
    31261 atatgatagc aaaaaaacta aatgcacata ttgataattt tagagaaagt gtaaaagaag
    31321 taaattctat gctagtgaat aataaatgtg ttggattata tattgatgaa ggatatcaag
    31381 ttgatactag gggatttaaa cttatagaaa gtaaggatga gttaagagat agtttttcaa
    31441 acacatatat agaaaaatta gttgtagtaa gcaataaaat aaattgtatt gaagatattg
    31501 agaatttaaa cctagataat aaatttgaac attgctatag taccaaaaaa ataataaagg
    31561 taattccaag agatatagtg ataggaattg gttgtagaag aaacacagat agtgaactga
    31621 tgtataattc acttgaagag tttcttaata aacaaaatat agatattaga gcaataaaca
    31681 cagttggaag tatagaactg aaaaaagacg aaaaagcaat aattgaatta tcaaaaatat
    31741 tgaaggtgcc atttaaaaca ttttcagtag atgaaatatc taaggttgat aatctttttg
    31801 ataaatctga ttttgttaaa aaaaatgtgg gcgtgtattc agtagcagaa cctgtagcat
    31861 atcttttgag caaaggtaat ttgttagttg aaaaacataa atataaagga ataacttttt
    31921 cagtggggag aataaaaata tgatatacgt tgtaggaatt ggaccaggaa gtaaagatac
    31981 aatgacttta gaagcaataa aagcaataga agattctgag gctattgttg gatataagac
    32041 ttatataaaa ctaatagaag aatttataca agataaagaa ataatccaaa atggtatgag
    32101 gcaagaagtt gatagatgta aacaagcagt agaggaagca aaaaaaggaa aaaaagtagc
    32161 agttgtaagc agtggtgatg ctggaatata tgggatggca ggtcttattt tagaattaat
    32221 atctaaagaa gatgaagata taaaagtaaa ggtaattcca ggtgttactg caagtattgg
    32281 tgcagcagct atacttggag ctcctattat gcatgatttc tgtcatataa gtttgagtga
    32341 tttaatgact ccgtgggaag taattgaaaa aagattgaga ttggccgctg aagccgattt
    32401 tgtaatttgt ttgtataatc caagaagtaa gggaagaagt gaacatctaa gcaaagcatt
    32461 taaaataatg ggtgagttta aaggtggaga tacacctgtt ggagtggtaa aagatgtagg
    32521 tagagaaaaa gaagaaaagt ttgtatgtac ttttgaaaat atggactttg aaaaagtcga
    32581 tatgactaca atggttataa taggaaataa gtctacctat attaatggtg aattgatgat
    32641 aactccaaga ggttatacag tatgatttta attttaggag gaacttcaga tagtttatct
    32701 atatgtgata agataaatga actgaaaaat caaccatata tcctttcagt tactacagat
    32761 tatggaaggg aacttgcaca acaacatgca gagaatgtaa ttttaggtaa gcttggaaaa
    32821 gaagatatgc taaaatttat aaaagataat aatatagtaa aaataataga tgccactcat
    32881 ccttatgcag ttgaagtatc caaaactgct attacttgtg caaaactatt gaatatagat
    32941 tatataaggt ttgagagaaa atctttaatt gaagaaatag attatgataa taaatttata
    33001 gtagatacaa ttgaagaagc ctgtgaaata gcaaataaaa tagggacaaa tatattcata
    33061 ggaacaggaa gtaaaaattt gaacagattt atagaggaaa taagtgataa aaatttagtt
    33121 gttagagttc ttccaacgag tgaagtcata ttaagttgtg aaaaattagg tttaagtgca
    33181 gataatatag tagctatgaa aggtccattt agccagtata taaatgaaga aacatataaa
    33241 cattacaata tagatttagt cataacaaaa gaaagtggaa tagctggtgg gttcttagag
    33301 aaggtaaatg catgtaaaac tttcaatata ccagtaataa ttataaaaag agaatcgatt
    33361 aactacgaaa atgtatttaa tgacataaat aaaattaaag acatacttgt gtaattttta
    33421 ggaggagaat atatgaagaa agccttatta gtagtgagtt ttggtacaag ctatcatgaa
    33481 acgagagaaa agacaataga tatatgtgaa gataaaataa aaaattcgtt aaaaagccat
    33541 gattttttta gagcttatac atcaaatatg ataataaata aaataaaaaa aagggatgga
    33601 atagaaatag ataatccaat acaggcttta gataaaatat atgaacaagg atatgatgaa
    33661 gtaataatcc aaacacttca tattatatgt ggcgaagaat ttaacaaatt aaaagaacaa
    33721 gtagatggat attcttctaa attcaaaaag attgtattag gaagaccttt gcttacacat
    33781 attgaagatt atcaggaagc tgtagaggca attaagcatc aaattcctca tatggaaagt
    33841 aatgaagcag tagtatttat gggacatgga acacttcatg aatcacattc agcgtatcca
    33901 gcattggaat acatgcttag ggataatgga ataaatgctt atgttggtac agttgaaggg
    33961 tatccagaaa tagaacatgt aataagaaga ttaaaagaag gaaatataaa aactgtaaat
    34021 ttgatgccat ttatgttagt tgcaggagac catgctataa atgatatggc aggagatgaa
    34081 gaagattctt ggaaaacaat attagaagaa aatggattta acgtaagagt tcatttaaaa
    34141 ggactaggag aaaattctta tatacaagat aaatttgttc gtcatgctgt aaaatgtgca
    34201 gagaatgcga agttctatgg tataggagca gggccaggag atggttcttt acttacgata
    34261 aaagcggtta atactttaaa gaaactggat attctataca ctccagaatc aaaaaagggt
    34321 ggagatagtc tagctttatc aatagttagt gaatatttac ctgaatcagt ggaaataaag
    34381 tctaggcatt tcccaatgag ttttgatggg aatgaaaaaa gtttagcttg ggacaatgtg
    34441 gcacaagaaa ttatatcaga tgttaatgat ggtaaaaatg taggatttgt tacattagga
    34501 gaccctatga tttatagtac atatgtatat ataatgaaaa gaatattagg agaggtagaa
    34561 gtcgaaacta taccaggaat ttcatcattt tccaatatag catctaatca gaattttcca
    34621 ttagtcatgg ataaagaagc tttagtggta attccttgta ctatggaaga tgataagata
    34681 gagtatgctt tgcaaaatta taattcaata gtattgatga aagtatataa aaattttaaa
    34741 gaaataataa aaaaattaga aaagtatgat ttaatagaac atgctatttt agtaagtaat
    34801 tcttcccaag aaagcgaaaa tgtgtttaca gatttaaaag aagcgcacct tgaagataag
    34861 atatcttatt tttctactat actagtaaat aaagataata aaataaaata ggtgaaagca
    34921 atatttaaag gagacttaat atgaatatag tggttggaac taggggtagt aatctagcgc
    34981 ttatacaaac agaatgggta ataaatgaat taaaaaagaa gtatccagaa attagttttg
    35041 agattaaaat cataaagaca aaaggagatt taattcaaaa tgtttcactg gataaaatag
    35101 gtgataaagg attgtttgtc aaagaaatag agcaacaatt attagatgga aaaatagaca
    35161 tagcagtaca tagtatgaaa gatatgcctt cttatttagc agatggacta aaatttgctc
    35221 atacgcctaa gagagaagac ccaagagatg ttctaatact tagagaagga tataaaaatt
    35281 tagatgattt acctcatgga gcagtaatag gaacaggaag taaaagaagg aagtttcaat
    35341 tattgaaaca aagacctgat ttaaatatag tacaagttag aggtaatgtg gaaactagga
    35401 tacgaaaaat aaaagatgaa aacatgcatg gtattgtgtt ggcagcatca ggaataatta
    35461 gagctaattt gcaagataaa ataagttctt atttacctgt tgatgttgtt attccagcac
    35521 ctgcccaagg agctttagct atagaaatta gaagcaatga tagtgcgata gagggaatag
    35581 taaattcact gaaggatgag aatacagaaa tccaaatatt ggctgaaaga ggttttttag
    35641 atggtgtaaa tggaagttgt catattccaa tggcagctta ttgtgaaata atccaagata
    35701 aaatacatct tactggctta tatggagatt cagaaggaaa aaaagtagta atcaagtcta
    35761 tagatggaga tatttcttct cctagagagt taggtttaaa gttagctaaa cttgtattga
    35821 aggagtatga gaattatgaa gggtaaggtt tacttagtag gggcaggacc aggtgattat
    35881 aaactcatga ctttaaaagg tttagagtgt ataagaaaat cggatgtaat agtatatgat
    35941 agattagcaa atagtagtta tttaagagaa gctaagcctg attgtgaact tatatatgta
    36001 ggcaaggcat caagtaatca tattttgcca caagaagata taaatagaat tatagcagaa
    36061 aaagctaaag aaggaaaaat tgtaactcgt cttaaaggag gagaccctta tgtatttggc
    36121 agagggggag aagaagcaga gactttagta gatgaaggta tagaatttga agtagttcca
    36181 ggtataactt ctgctatagg aggtttatgt tatgcgggta ttcctataac acatagagac
    36241 catgcttcgt catttcatgt aataacaggt catttgaagg gtgatgatag tggagaacta
    36301 aactggaatg ctcttgcaaa taacaaaggt actcttgtgt ttttgatggg aatttcaaac
    36361 ctagagaaaa taagtgaaaa cttaatgaaa gaaggaaaag ataaggatac acctgttgct
    36421 cttataagtt gggcaactag atataatcaa agagttgtta catctacact tgaaaatgtt
    36481 tatgaaactg ctattaaaga agaagtaaaa ccgccaactc ttatagtagt tgggagtgtt
    36541 gtaggactta gagaaaagtt gaacttcttt gaaagtaagc ctttatttgg aaaaagtatt
    36601 gctgtaacta ggtctagaaa tcaaaatagt gtattggtag aaaaaataat ggatttaggt
    36661 ggaaatccta tagaaatacc tactattaag gtagaaaaaa tacaaaataa tattaactta
    36721 gaaaatgaaa taaaaaatat aaataagtat aattatctaa tactaactag taaaaatgcc
    36781 gtagaaatct tctttgaaaa gatatatgaa atgaattttg atttaaggat attatctaat
    36841 ttaaaggtat gtgctatagg ttctgctaca tcaaatgagt tgaaaaaaag aggaattata
    36901 gcggatatag taccaaaaaa atttgtagca gagtcactgt atgaagagtt agcgcctatt
    36961 ttaaatgatg acgataatat acttatacct agagcagaaa atgctagaga ttatctggtt
    37021 gacaaactta aggctatttg tgaagtaaca gaagtacata tatatagaac agtaatagat
    37081 gaggagaaaa aaggtgagat attagatatt ttaaattcta atgacataga ttatataaca
    37141 tttactagtt cctcaacagt aaataatctt gttgaaatta taggaaaaga aaatattaaa
    37201 atattagaaa aaataaaaac actatctata ggtcctataa ctacagagac aataaatagt
    37261 ttgggaataa aattgtacaa agaatctgct acatctacta tagattcgtt agtagattta
    37321 attataaaaa attaattttg gaggcttgaa tatgttaaga agaccaagaa gactaagagc
    37381 aagtaaagca atcagaaatt tggtaagaga aactaaggtg aatgtagaag acttaatata
    37441 tccactgttt gtagtagagg gggaaaatat aaaagaagaa attaaatctt taccagatgt
    37501 ctatcattta tcaatagata tgctagaaga cgaaataaaa gaaataagtg agttgggaat
    37561 tgaacatata atgttatttg gtgttccaga tgaaaaagat gagtgtgctt cacaagcttt
    37621 taatgataat ggaatagttc aaaaggcaat tagaaaggta aaagaaataa attcagatat
    37681 aaatgtaata acagatgtct gtatgtgcca atatacaagt catggacatt gtgggatttt
    37741 aactgatact ggttatgttg ataatgataa atcattggag tatttggcta aaatatctgt
    37801 aagccatgct aaagcaggag ctgatatggt tgctccatct gatatgatgg atggaagaat
    37861 acaagcaata agagaagctt tagatgaaaa tggattagaa aatgttggaa tcatggctta
    37921 tagtgttaag tatgcttcaa attattatgg accttttaga gaggcagctc attcagcacc
    37981 atcttttgga gatagaaaaa catatcaaat ggacccagca aatagcaatg aagctataat
    38041 agagactgaa cttgatatat tggaaggtgc agatatactt atggttaaac ctgcattatc
    38101 atatttagat attataagaa gagttaaaga taattttgac ttacctctag cagcttataa
    38161 tgtaagtgga gaatactcta tgcttaagtt tgctgtgaag gaaggtttat taaatgaaga
    38221 tgtaattctt gaatcaatta catctataaa aagagcagga gcagatataa taataactta
    38281 ttttgctaaa gacattgcta aactgttgaa aaaataaatt ctagcagtat aaagaatatc
    38341 aaaaagtata ggaattgtaa ttaactatta tacagtagtt ttgtttagac atttattgaa
    38401 gaataataga aactaatttg caatttctat actttattta tgtaactaaa taaaatttgg
    38461 aggtagaaga tgctatatcc tattaattta aaattagatg agttagatgt agttataatt
    38521 ggtggtggag aagttgcata taggaaatgt aaaaattttt tagagtttaa caaaaatgtt
    38581 actatagttt ctaaacaaat tttaaataaa ttttatgatt taaaaggaaa tataaaaata
    38641 ataaaagatg attataaaga aatatatata aaagatgctt ctgtaataat tgctgccaca
    38701 aataatagag agttaaatat ggaaatagga ttatattgta aagcaaaaaa taagctagtg
    38761 aatgtagttg ataatataga aatatcgaac tttactgttc catcatatat aaaaagagga
    38821 gatttactta taagtgtgtc tactgggggc aagagtcctt cattatcatc aaagataaaa
    38881 aaagaaattg aagagagata tactgaagat tatgaggagt atttaaatgt attaggagat
    38941 ataagaaaaa aggttataaa aaaatacgaa gataaaagta aaagaaaaga tgtgcttaat
    39001 atgttggtaa cacttgacct agaagaactt aagaagtttg atatataaaa aataaaataa
    39061 aaaatgttaa aaaggtgttg acggattatt tttaag
//
LOCUS       DAEPID010000035        38708 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.035, whole genome shotgun sequence.
ACCESSION   DAEPID010000035 DAEPID010000000
VERSION     DAEPID010000035.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 38708)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 38708)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..38708
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.035"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            complement(<1..896)
                     /locus_tag="KR257_001960"
     CDS             complement(<1..896)
                     /locus_tag="KR257_001960"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009243519.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional lysozyme/C40 family peptidase"
                     /protein_id="HBH0030664.1"
                     /translation="MKLKHIAIIGSLFPILFSIVLFFGVLMSADSDDENSNFSSGITG
                     MNLSAEVLKHQPMVEKYAKEYGISEYVNVLLAIIQVESGGTAKDVMQSSESLGLPPNS
                     LDTESSIKQGCKYFASLLSSCKNQGINDLNVAIQSYNYGGGYVGYVAGKGKKHTFNLA
                     ESFAREKSGGKKVTYTNPIAVAKNGGWRYGYGNMFYVELVNQYLTVPQVSGELAQKVM
                     NEALKYQGWKYVYGGSNPNTSFDCSGLTQWCYGKAGISLPRTAQMQYDATQHIPLSQA
                     KAGELVFFHSTYNAGSYVTHVG"
     gene            complement(893..3085)
                     /locus_tag="KR257_001961"
     CDS             complement(893..3085)
                     /locus_tag="KR257_001961"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002323347.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YtxH domain-containing protein"
                     /protein_id="HBH0030665.1"
                     /translation="MKERIQSAFTKKKIFHFLKMALFVVALSLILLSLLGTVAHATGL
                     VDDTINAENLYSKYPLSNYQLDFYVDNSWAWLPWNWLDGIGKSVQYGLYCITNFVWTI
                     SLYLSNATGYVVQEAYKLDFINDMADSIGQSIQTLAGVTSSGFSTSGFYVGFLLLIIL
                     VVGLYVAYTGLIKRETSKALHAVINFVVVFILSASFIAYAPDYIKKINEFSSDISTAS
                     LDLGTKIMLPNSDSEGKDSVDLIRDSLFSIQVEQPWLLLQFGNSNAEEIGTDRVEALV
                     SASPENEDGKTREEVVKTEIESNDNNNLTIPQVVNRLGMVFFLLFFNLGITIFVFLLT
                     GMMLFSQILFIIFAMFLPISFLLSMIPSYESMAKQAIVRVFNTIMTRAGITLIVTVAF
                     SISSMFYNISTDYPFFMVAFLQIVCFAGIYMKLGDLMSMFSLNANDSQSMGRRIFRRP
                     YLYMAHRARRMERRLAGAVTAGGVAGAVAGSTVSNARTTRNNSAKDNRGNTSSSMGQR
                     AGSKVGAVLDTKNKVKDKANAMKETVKDIPTQTAYAVHSAKEKAKTSVSDFKRGMVQE
                     QQSRQSGRLEKQEQHKKNIADKRMELQKAQEARQARKTDGSATTGATRPHERPVTASA
                     IPKTNVEKTQEVKRPATTSTSKAGEPVKTNSVKERPLSSGTSDGKIPQSAQTVHSKNV
                     EKVVSHETHQNYKAERTTKAQTVEQAKRTTEHTEKNRNLVTKKGQKKK"
     gene            complement(3085..5535)
                     /locus_tag="KR257_001962"
     CDS             complement(3085..5535)
                     /locus_tag="KR257_001962"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898619.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding protein"
                     /protein_id="HBH0030666.1"
                     /translation="MFPIKYIDNNLVWNKDNEVFAYYELIPYNYSFLSAEQKFIVHDS
                     FRQLIAQSREGKIHALQIATESSIRSMQEQSKRLVTGKLKEVAYQKIDEQTEALVSMI
                     GDNQVDYRFFLGFKLMVTEEQLNLKNLKKSAWLTFKEFLHEVNHTLMNDFVSMPNDEI
                     NRYMKMEKLLENKISRRFKVRRLEINDFGYLMEHLYGRDGIAYEDYEHQLPKKKYKKE
                     TLIKYYDLIRPTRCVIEESQRYLRLEHEDKESYVSYFTVNAIVGELDFPSSEIFYFQQ
                     QQFTFPVDTSMNVEIVENRKALTTVRNKKKELKDLDNHAYQAGSETSSNVVDALDSVD
                     ELETDLDQTKESMYKLSYVIRVSADDLDELKRRCDEVKDFYDDLNVKLVRPAGDMLGL
                     HSEFLPASKRYINDYVQYVKSDFLAGLGFGATQQLGENTGIYMGYSVDTGRNVYLQPS
                     LASQGVKGTVTNALASAFVGSLGGGKSFCNNLLVYYSVLFGGQAVILDPKSERGNWKE
                     TLPEIAHEINIVNLTSDKDNAGLLDPFVIMKNVKDAESLAIDILTFLTGISSRDGEKF
                     PVLRKAVRSVTQSETRGLLHVIDELRCEDTAISRNIADHIDSFTDYDFAHLLFSDGTV
                     ENAISLDNQLNIIQVADLVLPDKDTTFEEYTTIELLSVSMLIVISTFALDFIHSDRSI
                     FKIVDLDEAWAFLNVAQGEILSNKLVRAGRAMQAGVYFVTQSSGDVSKESLKNNIGLK
                     FAFRSTDINEIKQTLEFFGIDKEDENNQKRLRDLENGQCLLQDLYGRVGVVQIHPVFE
                     ELLHAFDTRPPIQRNEVE"
     gene            complement(5522..5911)
                     /locus_tag="KR257_001963"
     CDS             complement(5522..5911)
                     /locus_tag="KR257_001963"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009274602.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="conjugal transfer protein"
                     /protein_id="HBH0030667.1"
                     /translation="MKKIRSYTGIWNVEKVLYAINDFNLPFPVTFTQITWFVITEFII
                     ILFGDMPPLSMIEGAFLKYFGIPAFLTWFMSQKTFDGKKPYSFLKSQITYALRPKITY
                     AGKAVKLQKEIFNETITAVRSVSYVPD"
     gene            complement(6029..6532)
                     /locus_tag="KR257_001964"
     CDS             complement(6029..6532)
                     /locus_tag="KR257_001964"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004843360.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="antirestriction protein ArdA"
                     /protein_id="HBH0030668.1"
                     /translation="MIDDMAVYIANLGKYNEGYLVGAWFTFPIDEEDVKEKIGLNEQY
                     EEYAIHDTDNFPIEIGEYVSIDELNEMYEMIEELPDYIVDCLDEFIGHYGTLEEVVEH
                     KDDIYYYPDCETMTDVAYYYIDELQALGDIPPSLQNYIDYEAYGRDLDMGGCFIATSR
                     GMCEIPY"
     gene            complement(6535..7038)
                     /locus_tag="KR257_001965"
     CDS             complement(6535..7038)
                     /locus_tag="KR257_001965"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004843359.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="antirestriction protein ArdA"
                     /protein_id="HBH0030669.1"
                     /translation="MQETRVLVETKRTTGEETTSYWFDLPIEVAEFEEKLGVSTESQD
                     YRIIEKLLPYADEVHEHTSVYQLNELDYMYRQLSSDMQEEYTMLHTVYENLEALYICR
                     NVITLYPDCKSMIDVARQKLMNDPTFKHLSEDCQEYYFDFETYASHLQEHGKFLVTEH
                     GIFELPE"
     gene            complement(6957..7253)
                     /locus_tag="KR257_001966"
     CDS             complement(6957..7253)
                     /locus_tag="KR257_001966"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005339688.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="conjugal transfer protein"
                     /protein_id="HBH0030670.1"
                     /translation="MNDIFRDMQAKVGCENISDLPSYKRKVWHEMKQLNLADYEEKQL
                     EDFSKYVFGMSCQTLKDVMKQQKGREEQCRKQGYWWKRKEQLAKKQHHTGSTCR"
     gene            complement(7350..7952)
                     /locus_tag="KR257_001967"
     CDS             complement(7350..7952)
                     /locus_tag="KR257_001967"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437218.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha/beta hydrolase"
                     /protein_id="HBH0030671.1"
                     /translation="MDKVVIYIHGKGGNAEESSHYKPLFSDCDVVGLNYTAQYPWEAK
                     EEFPSLFDLICKHYKSVQIVANSIGAYFAMNALSDKQIEKAYFISPIVNMEKLIADMM
                     YWANVTEDELRDKKEIKTTFGETLSWEYLCYVKENPTTWKIPTNILFGEKDNLTSYAT
                     ISEFTKQTNATLTVMRNGEHWFHTEEQMKFLDEWINKSAR"
     gene            complement(8037..8198)
                     /locus_tag="KR257_001968"
     CDS             complement(8037..8198)
                     /locus_tag="KR257_001968"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002322988.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0030672.1"
                     /translation="MAIVVIGIYLGFKREFSKLIGFLVVALVAVGLVFNAGGVKDVLL
                     ELFNKIIGA"
     gene            complement(8365..10275)
                     /gene="ltrA"
                     /locus_tag="KR257_001969"
     CDS             complement(8365..10275)
                     /gene="ltrA"
                     /locus_tag="KR257_001969"
                     /EC_number="2.7.7.49"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002347258.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="group II intron reverse transcriptase/maturase"
                     /protein_id="HBH0030673.1"
                     /translation="MPKNKNETLCVEDLRHAEYYEMQNTFDDLYAKSKNGDIFTHLMD
                     IILSRENILLAYRNIKANAGSKTAGTDGTIIKDIGKLPAETVVKKVRYIVAGSPHGYR
                     PKPVRRKEIPKPNGKTRPLGIPCMWDRLIQQCIKQVLEPICEAKFSENSYGFRPNRSV
                     ENAIKATYNRLQISQLHYVIEFDIKGFFDNVNHSKLIKQIWAMGIRDKHLIFILKRIL
                     KAPIKMTNGTITYPEKGTPQGGIISPLLANIVLNELDHWVESQWQENPVTKNYVVHIN
                     KSGSPCKSNAYKEMKKTKLKEMYMVRYADDFRVFCRYKESAEKAKIAITQWIEQRLKL
                     EVSQEKTRIVNVRKRYSDFLGFKIKMIPRRKKLVVKSHISDKQFKNQKDKLVSQAKKI
                     ASPSKGKTELEETRLYNSMVLGMQNYYQIATNVNLDCMKLNRAVMAIFTNRLGTNKRG
                     RLRKTGRQLTTKEATRYGKSKMLRYVAGEGEPIFPVGYIQHRKPMAKVYLANCYTLEG
                     RKFIHTNLSVDKLLMYQLMKLSLENRTIEYADNRISLFSAQHGKCAITLEEFQQANEI
                     HCHHIVPTGAGGNDDYKNHILVKEAVHRLIHAKTEETIQKYIALLKLNKVQLIRLNKY
                     RVLAGNQELNLI"
     gene            complement(11017..11151)
                     /locus_tag="KR257_001970"
     CDS             complement(11017..11151)
                     /locus_tag="KR257_001970"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017143882.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3789 domain-containing protein"
                     /protein_id="HBH0030674.1"
                     /translation="MWELLKDLLLVSFGMGIGVVLMCILTVGKEADRCMEEIKEREDN
                     "
     gene            complement(11159..12358)
                     /locus_tag="KR257_001971"
     CDS             complement(11159..12358)
                     /locus_tag="KR257_001971"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002319753.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="XRE family transcriptional regulator"
                     /protein_id="HBH0030675.1"
                     /translation="MNETDFLTALKEKRCAYGVSQTRLAIMANISREHLSRIEAGKVT
                     LTEDMKHTLLEAVEKFNPNNPMFLLFDYVRIRFPTMDIKHIIKDILKLNIGYMLHEDY
                     GHYKYTEHYHIGDVFVYVSQDEEKGVLLELKGKGCRQFESYLLAQERSWYDFFTDALV
                     EGGVMKRLDLAINDRTGLLDIPELIRKCENEECISKFRSFKSYGSGELVKHNETDKYG
                     MGHTLYIGSFSSEVYFCCYEKNYEQYAKLGIPIEEVPIKNRFEIRLKNERAYYAVVEL
                     LTHYDAELTAFSIINQYIRFADKEPDKRKSDWKTNVRWAWFIGEGRPPVKLTTQPEPY
                     TLERTLNWLQRQVAPTLKMLKQIDKDNQTEYLETIEKQAKLTERHYQIIKQQTATVEE
                     MVANVKE"
     gene            complement(12560..13954)
                     /locus_tag="KR257_001972"
     CDS             complement(12560..13954)
                     /locus_tag="KR257_001972"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008787614.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding protein"
                     /protein_id="HBH0030676.1"
                     /translation="MKMILNKGHRIRASDKNLVYHFSIGTLLFVFIAVILLLNMKQLM
                     RTDWEHFSLLDNGLTLSTYNFITLLIATGVCALVAFLYYRFCYDSFKKLLHRQKLARM
                     ILENKWYEADTVQDSGFFTDLQSRSREKIIWFPKIYYQMEKGLLHIRCEITLGKYQDQ
                     LLRLEDKLESGLYCELTDKTLHDGYIEYTMLYDMIANRITIDEVKAENGCLRLMKNLV
                     WEYDALPHALIAGGTGGGKTYFLLTLIEALLHTNAVLYILDPKNADLADLGTVMGNVY
                     HTKEEMIDCVNAFYEGMVQRSEEMKRHPDYKTGENYAYLGLPPCFLIFDEYVAFFEML
                     GTKESVSLLSQLKKIVMLGRQAGYFLIVACQRPDAKYFSDGIRDNFNFRVGLGRISEL
                     GYGMLFSSDVKKQFFQKRIKGRGYCDVGTSVISEFYTPLVPKGHDFLQTIGSLAYARQ
                     DGTATCEAKGDGTD"
     gene            complement(14071..14556)
                     /locus_tag="KR257_001973"
     CDS             complement(14071..14556)
                     /locus_tag="KR257_001973"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006776881.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0030677.1"
                     /translation="MAKEKGSFKEFLSAIAPEHQAFVEKLNTKLIEQGCDLVIKEAKS
                     GYTASYQLEKKTVMNWVFRKTGVFARIYGDNAGKYEDIIASLPADMQKKMTTSRDCKR
                     LIDPNACSDTCVKGFVYALNGDTHKKCRNDGMLFVLTNETAEHIAGLVCAEVNVRKSA
                     L"
     gene            complement(14654..15037)
                     /locus_tag="KR257_001974"
     CDS             complement(14654..15037)
                     /locus_tag="KR257_001974"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014080829.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YdcP family protein"
                     /protein_id="HBH0030678.1"
                     /translation="MRLANGIVLDKEKTFGVLKFSALRHEVRAENDDGSTSEEITRRT
                     YDLKCSVQERMIQVSIPADIPVKDYPYNAEVELVNPVADTVANASYRGVNVDWYIKAD
                     DIILKNKGGQVGNPQNHAPQGQPKK"
     gene            complement(15052..15378)
                     /locus_tag="KR257_001975"
     CDS             complement(15052..15378)
                     /locus_tag="KR257_001975"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005337695.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YdcP family protein"
                     /protein_id="HBH0030679.1"
                     /translation="MELKYVVPNMAQTFGNLEFAGENKIEQQRINGRFTPVSRSYNLY
                     SDVQRADDIIVTIPAKAGEKHFKPEQRVKLINPKITADGKAVKGRGFTNYILTADDML
                     PAEESK"
     gene            complement(15614..18658)
                     /locus_tag="KR257_001976"
     CDS             complement(15614..18658)
                     /locus_tag="KR257_001976"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861958.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SrtB-anchored collagen-binding adhesin"
                     /protein_id="HBH0030680.1"
                     /translation="MKKILKRLCTGVLAFATVVTALPTTLVHAESKQYWTESEERVGI
                     VEKVMNDGSIGSTFNEGHLTVEGEDAYCIDINTDFKNGYKTRADASSRMSADQISDVA
                     LSIEYVKQYTDNHNGISKNHAYLLRQLVVWQRLSVHLGWQCDNVRASYDEIPKATQDE
                     VFAGAKAFVKENKGRYECGGYIYSGEGQELGQFWAKLNVGNAKLQKTSNNTSITNGNG
                     NYSIAGATYGVFSDKDCTKQIATLTTDDSGNTEVAEVKATTVYIKELSAPLGYKVDTT
                     VYSLKVEAGKTATLKVSDTPKVTDTLIELFKIDMETQKANPQGNASLEGAEFTWKYYA
                     GFYNKDNLPAEATRTWVTKTTAETDSNGTTHYITKLADAYKVSGDSFYMQDGKAFLPL
                     GTLTVEETKSPTGYLLDGAYMQANGSEEQIKALYLTQITEDGDLAVLTGSNQFSVSDK
                     VIRGGVKIQKRDLETKDTKPQGSATLKDTAFDIISLNDNAVLVEGKIYKKNEVVKTIH
                     TDIEGIASTSADLLPYGNFRIVEKQAPNGYLTDGAKPIDFTITENGKIVDLTDEAHSI
                     YNQIKRGDIEGVKIGAGTHKRLADVPFRITSKTTGESHVVVTDDNGQFSTSSKWASHK
                     HNTNAGKTSEDGVWFGTSEPDDSKGALPYDTYIIEELRSDSNKGMELIPPFEIVVSRN
                     NLVIDLGTLTDEYEKEITIHTTATSKDGEKTILAGKEVTIVDTVKLDGLTKGTKYQLK
                     GWQMLKEENAEIIIDGKRVESDYTFVADDEEMKVEISYTFNASELGGKNLVTFEELYD
                     LSNPDEPMKVAEHKDIEDDGQTVLITERIIKIHTTATDKDGNKELEAGKDVTIIDTVT
                     LEGLEVGTKYKLVGWQMLKEENAELLINGKRVESDYTFIADSETMKVEVTFTFDATSL
                     DGKQLVTFEELYDLSNPNEPKKVTEHKDIEDEGQTITFKEKPEVPEKPETPTTPEKPS
                     RPTDSPKTGDNTNVMAFLVMLLTSAGGLAGTYLYKRRKMKKS"
     gene            19186..20193
                     /gene="asrA"
                     /locus_tag="KR257_001977"
     CDS             19186..20193
                     /gene="asrA"
                     /locus_tag="KR257_001977"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903096.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="anaerobic sulfite reductase subunit AsrA"
                     /protein_id="HBH0030681.1"
                     /translation="MKLKLDSSKFNEGLNYLKKDYKIFAPVLIPFKGTFSDTDVIRYK
                     EVNAFEEMEFAKKANFSPKDVVLPINQVLFYFTEKEFKESDLDNKKILIFLRACDING
                     IKRLDEIYLNNGEEKDYFYKNIRDKVKFALVGCKESFRNCFCVSMDSNKTDNYSIGLN
                     IEGDTLYLDIKDSEFEVFNGEATEFNVDYVTDNLISVDVPENIDSNEMIGNSIWDEYD
                     TRCIGCGRCNFVCPTCSCFTMQDIFYKENENVGERRRVWASCQVDGYTDIAGGNSFRK
                     KQGERMRFKTMHKIHDFKKRFGYHMCVGCGRCDDACPQYISFSKCIEKINDLVISKEE
                     V"
     gene            20194..20985
                     /gene="asrB"
                     /locus_tag="KR257_001978"
     CDS             20194..20985
                     /gene="asrB"
                     /locus_tag="KR257_001978"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423354.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="anaerobic sulfite reductase subunit AsrB"
                     /protein_id="HBH0030682.1"
                     /translation="MNPYIPVSAKILDIVKHTDKEWTFRVNCNTKGVLPGKFYEISIP
                     KYGESPISVSGYGEDYIDFTIRNVGKVTSELFNYKEGDSFFIRGPYGNGFDVSLYEGR
                     EIVVVAGGSALAPVRGIVEYFYNNKEKCEKFKLIVGFKSPKDILFADDLKRWSKKLDI
                     LVTVDGAEEGYSGNVGLVTKYIPELDMKDINNTSIVVVGPPMMMKFTVEEFLKRDLDE
                     KNIWVSYERKMCCGIGKCGHCKMDDTYICLDGPVFDYSYAKNLID"
     gene            20998..21969
                     /gene="asrC"
                     /locus_tag="KR257_001979"
     CDS             20998..21969
                     /gene="asrC"
                     /locus_tag="KR257_001979"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430464.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sulfite reductase subunit C"
                     /protein_id="HBH0030683.1"
                     /translation="MIRDLNTKKVMKNAYRITKTKYETSLRVRVPGGLIDPESLAVVS
                     KIASEYGNGQVHITTRQGFEILGINMEDMEEINKIIQPVIEKMNINQSEKNAGYPAAG
                     TRNIAACIGNKVCPKAQYNTTEFAKRIEKAIFPNDLHFKVALTGCPNDCIKARMNDFG
                     IIGMALPIYEKDRCVNCGACVKKCSKISVGALKTENNKVVRDKDKCIGCGECVLNCPT
                     NAWTRDEKKYYRLAIMGRTGKKNPRLAEDFLLWVDEDSIIKIILNTYRYVEKYIDKDA
                     PGGKEHIGYIIDRTGFMEFKKWALEGVELPEITKMYENIYWSGIKYL"
     gene            22026..22802
                     /locus_tag="KR257_001980"
     CDS             22026..22802
                     /locus_tag="KR257_001980"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729086.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="formate/nitrite transporter family protein"
                     /protein_id="HBH0030684.1"
                     /translation="MHKETLDKLTNAAINKINLLNTSKVKYLVSSAFAGLYVGIGILL
                     IFTIGGLLTDAGSPMTKIVMGLSFAIALSLVIMTGTELFTGNNMVMSAGMLNKGVSIK
                     DTSKIWAYSWVGNLIGALVLGIIFVGTGLVDKGPVAEFFANTAASKASMPFTALFFRG
                     ILCNILVCVSVLCSFRTNSDTAKIIMIFLCLFAFITSGFEHSVANMTIYSVSLFSPTI
                     STVTIGGAIYNLVAVTLGNIVGGALFMGLGTYILGKEKLN"
     gene            23073..25091
                     /locus_tag="KR257_001981"
     CDS             23073..25091
                     /locus_tag="KR257_001981"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729087.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="FUSC family protein"
                     /protein_id="HBH0030685.1"
                     /translation="MTKKLVISKTKLFIFIIAFISIFIYLFGSKNTLIGVGIVTAMLT
                     LLERDLTISPIKNLLKYLAINIILGILSFFAVQNMYLGVLLNFIALFIIGYVFSYDLK
                     RAVYVPFGLMYIFMVSIPVGKSEFPMRLSALAVGAVIIMIAQFVMNRNRMKNVGDKEL
                     ISICDELLEKISLLKNTINDDSSIIKSSMRKIDSCNYRINSISKNLKMVIFDNRKDDF
                     YISIRGIDIMNILFSLERISLILERYKKDSKEFEDEDIKNILEESSINSKSDVLVVAT
                     KEINYIKMCLENKDTITDKEILGFRDYVIAQDTKNINLKEIYSVLENLYEFLVDYKKV
                     KSRDEKKAERKSKIPHEFKRLSIYKKNFNLNSIRFSYAVKIALATAVAGFIMDYFHLR
                     DGRWIMLTVFSLTQPYAENCIQRSRKRIEGTFIGAVIFIVLFSIIKDSTLRSLIVLLA
                     GYINSYVVDYRKLMVCVTVSALGSAVVMGDPNVLTISRISYVALGAIIALIVNKFILP
                     YDAKTGYQHVIEMYKGIVKNIIDEVNKSIENVADVYYIKNLLLIPSLIEDRLMLINAI
                     YKDKHQEDFLENQKLLISNMYNLYINVNKNKIKDEDVEKILRDTNYISNYNVDKYDEG
                     RSVILESIVNTKSLGDKIICLNLLQTLNGVKEMYRISNITKVSIKEAA"
     gene            25306..26163
                     /locus_tag="KR257_001982"
     CDS             25306..26163
                     /locus_tag="KR257_001982"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890403.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha/beta hydrolase"
                     /protein_id="HBH0030686.1"
                     /translation="MSKDVKVKRNKKYDTFSITMELERPLLYDEVENKDDKNNNRKFN
                     IKNKIFKGIGILFVLILLGFFIWINKTYEPQKLAKEALVSNSKVEVTVNENISFTPKG
                     RKVSKGLILYPGAKVEIESYAPLARKIAESGYEVVIVKMPLNLAILGTNKAQKVMDSY
                     NNIEHWVIGGHSLGGVAASNFARDNKLIEGVVFLASYPMGDELKELGKKVISIWGSKD
                     GVVNFKSLVESKQKLPDDTTYVEIEGGNHAQFGDYGKQKGDNDAIISQEKQLNITANS
                     IIKFLKNIS"
     gene            26260..27129
                     /locus_tag="KR257_001983"
     CDS             26260..27129
                     /locus_tag="KR257_001983"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003433836.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="radical SAM protein"
                     /protein_id="HBH0030687.1"
                     /translation="MEYDMPLYRPPSEAYSLIIQVTLGCSHNKCTFCSMYKSKKFKIK
                     PLEVIKNEIDIFRRYYKHVERIFLADGDALIIPMEKLRDIILYIKEVFPECERITMYG
                     SPKSIEKKSDDELKELRKLGVKMIYLGLESGSNEVLEDIKKGFSSEQLIKVGRKVKKS
                     GIKLSATVIAGLGGTKKTHQHAVDTGKMLGAISPDYVGVLSLMVEPNTELYDLLKAGE
                     FTILEDKAVLQEIKEMIKNIDANEKIVFRSNHASNYANLKGVLPDDKQRLIDEIDYYL
                     SNQKLKREEYRRL"
     gene            complement(27500..28132)
                     /locus_tag="KR257_001984"
     CDS             complement(27500..28132)
                     /locus_tag="KR257_001984"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003433837.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CatB-related O-acetyltransferase"
                     /protein_id="HBH0030688.1"
                     /translation="MTIPSSNKVYPRSNDYQTVYLKNVITRENIEVGDYTIYNDFYND
                     PRDFEKNNVLYHYPINNDKLIIGKFCSIACNAKFLMTSGNHSMKSKSTYTFPIFYEEW
                     KLDINHITDAWDNKGNIIIGNDVWIGYDSIIMSGVNIGDGAIIGTRAVVTNDVPPYSI
                     VGGVPAKIIKKRFNNDTISKLLEIKWWDWPYKKIQSNIKHIQSGNIDKLV"
     gene            complement(28204..28557)
                     /locus_tag="KR257_001985"
     CDS             complement(28204..28557)
                     /locus_tag="KR257_001985"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897397.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="integrase DNA-binding domain-containing protein"
                     /protein_id="HBH0030689.1"
                     /translation="MSTEKRRDNKDRILRTGESQRKDGRYAYKYVYSFGKPQFVYSWK
                     LVPTDKPPKGKRDDISLRDKEKAIQNDLDDSIDTIGKKMTVCQLYAKKNGLRKNIRLN
                     TKKGRHYLMKILNKE"
     gene            complement(28635..28838)
                     /locus_tag="KR257_001986"
     CDS             complement(28635..28838)
                     /locus_tag="KR257_001986"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002262306.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="excisionase"
                     /protein_id="HBH0030690.1"
                     /translation="MNNTDVPIWEKYTLTIEEASKYFRIGEKKLRKLADENLDSGWVI
                     MNSNRIQIKRKQFEKIVDTLDFI"
     gene            complement(29228..29458)
                     /locus_tag="KR257_001987"
     CDS             complement(29228..29458)
                     /locus_tag="KR257_001987"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897394.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="HBH0030691.1"
                     /translation="MKPTKEVLPFTIILLAVHGDVNAINGILKHFEHYIIRLSQKTLF
                     DEYGNPYIHVEEETKRMLGTKLITAILRFNLS"
     gene            complement(29460..29867)
                     /locus_tag="KR257_001988"
     CDS             complement(29460..29867)
                     /locus_tag="KR257_001988"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897392.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sigma-70 family RNA polymerase sigma factor"
                     /protein_id="HBH0030692.1"
                     /translation="MVDEKTIEHQFDSFCKTVLRNYARDIYDENKRRNDYLVSLESLS
                     LAELSKLSILDDYDSNYICMVSYDYNIRIEDVLMAQAIGKLTKRKQDIILLSFFLNMT
                     NADIATLMDLAENTIHYHKTNALKELKELMEEH"
     gene            complement(30227..30676)
                     /locus_tag="KR257_001989"
     CDS             complement(30227..30676)
                     /locus_tag="KR257_001989"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729090.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HBH0030693.1"
                     /translation="MELIEWNYAYITDLVEFANDKEIAKNLRDNFPHPYREQNARDFV
                     SFCLATPDVKQLSYAIFYQERAIGSISLTFEEDTSINKNAELGYWLARNYWGKGIATN
                     AVKEICKIAFEKYNLNKIHANVYSYNRGSSKVLEKCGFKIEEYCHNS"
     gene            complement(30690..31616)
                     /locus_tag="KR257_001990"
     CDS             complement(30690..31616)
                     /locus_tag="KR257_001990"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903090.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0030694.1"
                     /translation="MSDILSRITNKIGDKNIVDKLSALSKSDLNSLLLEVFDRQANTL
                     TATDILKSYQLNRFTIPSGIDPEEIHALESKLLRKAFNMDIKTIMLSPSAPLGSCSVF
                     GSVDQYNVVSALRGTETLADPSNMLAIIIADKLKRKEENNTIPIHMATTARVIRAQNF
                     VGKGLYSHFGLYCMVSSGIDTGSYTCEKMLLEKHLNYYKDILSEIENVRFSIILRKRN
                     GYKDNDGFFDRMVETIKLIFPNIELSIHNDDVDNNYYKGINFKLSVKQGNETVEIVDG
                     GFVDWTYQMLGNKKERCLISGIGLERFLVAVS"
     gene            complement(31741..32145)
                     /locus_tag="KR257_001991"
                     /pseudo
     CDS             complement(31741..32145)
                     /locus_tag="KR257_001991"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003433844.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="oxalate:formate antiporter"
     gene            complement(32295..32915)
                     /locus_tag="KR257_001992"
     CDS             complement(32295..32915)
                     /locus_tag="KR257_001992"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423956.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Crp/Fnr family transcriptional regulator"
                     /protein_id="HBH0030695.1"
                     /translation="MHLIDFMNEDIKKKLVKKTYKKKETILFAEQENEYVILMIDGIA
                     EAFILNVKGNISTIHLYRSGSFFGEMEQFNDGKKPVEIVAFTDCNVYKLHRDDFLNWL
                     RGDFEATKFLIREISSKLVVNAELIEELSSLSVKERLLRCISLHYYRSELNLLTKKQL
                     ASEVNAPIRSINRAINECVQEHLIAYENKRFSVINQREVLKNLPTT"
     gene            complement(33014..34282)
                     /locus_tag="KR257_001993"
                     /pseudo
     CDS             complement(33014..34282)
                     /locus_tag="KR257_001993"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000331151.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding protein"
     gene            34374..35189
                     /locus_tag="KR257_001994"
     CDS             34374..35189
                     /locus_tag="KR257_001994"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897377.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phage integrase family protein"
                     /protein_id="HBH0030696.1"
                     /translation="MVKLSDAKSWAIRMSEDGCAYKSIDNYKRSLKASFFMAIQDDCI
                     RKNPFNFQLSDVLEDTTEPKIALTPEQEMGLLSFMESDKTYCKYYDDVVILLETGLRI
                     SELCGLTLELDMKNKAIMVDHQLLSDTKIGYYVEVPKTTQGKREIPMTERAYQSFERI
                     VERRKNAKAEPIIVDGYQNFLFLKQDGLPKQATHYQSMLRALVKKYNKTHEDKLPKIT
                     PHTFRHTLCTNMANKGMSPNILQYIMGHKNITMTLGYYAHGSFSSSRAEMERL"
     gene            35861..36628
                     /locus_tag="KR257_001995"
     CDS             35861..36628
                     /locus_tag="KR257_001995"
                     /EC_number="4.2.1.10"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897376.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type I 3-dehydroquinate dehydratase"
                     /protein_id="HBH0030697.1"
                     /translation="MKRKVQVKNITIGEGRPKICVPIIGKNKKDIIKEAKELKDACLD
                     IIEWRVDFFENVENIKEVKEVLYELRSYIHDIPLLFTFRSVVEGGEKLISRDYYTTLN
                     KEISNTGLVDLIDVELFMGDEVIDEVVNFAHKKEVKVIISNHDFNKTPKKEEIVSRLC
                     RMQELGADLPKIAVMPQNEKDVLVLLEATNEMFKIYADRPIITMSMSGMGVISRLCGE
                     IFGSALTFGAAKSVSAPGQISFKELNSVLNLLHKSIN"
     gene            complement(36956..37633)
                     /locus_tag="KR257_001996"
     CDS             complement(36956..37633)
                     /locus_tag="KR257_001996"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003433851.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0030698.1"
                     /translation="MIVIEGSDKFKIAKEYIDVEYTLFSKVTFRYEKLKFKDNAELEK
                     IKMFKYKNGYIPNKLNLSFGYGFSSYKKQIIRETVDTLRLTEIFSSENIEDIKFIKDG
                     TKKLEISIEKVVKFKRRKKRNYVCCYCPDMYRDIKLDKESINKIYNRKIKIEREVNIF
                     EDEDVIINKKVLKFPKSWTKNMQKYWLSENKYPIHSTVIDDDRYKCCNVQYTKNRVII
                     LYYIYNH"
     gene            complement(37783..38100)
                     /locus_tag="KR257_001997"
     CDS             complement(37783..38100)
                     /locus_tag="KR257_001997"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890395.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HBH0030699.1"
                     /translation="MNYIGKRLKEERKKANLTSKEFANMVGVSPWYITQIESGKKNPS
                     LKTFIKFVNILNISADVLIKDITSTGKTYLENDINEELKDLNSRELNLISQIIDIIKK
                     NKI"
     gene            complement(38122..38460)
                     /locus_tag="KR257_001998"
     CDS             complement(38122..38460)
                     /locus_tag="KR257_001998"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423377.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HBH0030700.1"
                     /translation="MANIGKIIGDRIKVYRTKLGYSQEFLAEKAGLHPTYIGQIERAE
                     TNTSINIIMKIATALDIPLELLFANIITTEGVDNSVPLECYEMINKLTEKEQIAMLEL
                     IKCIIKYKEI"
BASE COUNT        12077 a         6822 c         6652 g        13157 t
ORIGIN      
        1 attcccacat gggtaacata cgaaccagcg ttataggttg aatggaaaaa gaccaactcc
       61 ccagcttttg cctgcgataa agggatatgc tgggttgcgt catattgcat ttgtgccgtt
      121 ctcggtaaag agataccagc ttttccataa caccattgcg tcagtcccga acagtcaaag
      181 gaagtgttgg gattgctacc gccatacaca tatttccagc cttgatattt caacgcttca
      241 ttcattacct tttgtgccag ttctcccgat acctgcggaa cagttaaata ctgattgact
      301 aattccacat aaaacatatt tccatagcca taccgccagc ccccattttt cgcaacggct
      361 atcgggttgg tgtaggttac ttttttaccg ccagatttct cacgggcaaa gctctctgca
      421 aggttaaaag tatgtttctt tccttttcct gccacatatc ccacatagcc accgccatag
      481 ttataggact gtatcgccac attcaaatca tttattcctt gatttttgca ggaagaaagc
      541 agggacgcaa aatatttaca cccctgcttg attgagcttt ctgtatctaa cgagttgggc
      601 ggtaaaccaa gactttctga actctgcatg acatcttttg ccgtaccgcc actttctact
      661 tgaatgatag ccagtaacac attcacatac tcagaaatac cgtattcttt agcgtacttt
      721 tccaccatag gctgatgttt caagacttct gcggataaat tcatacccgt aatgcccgaa
      781 gaaaagttgc tgttctcgtc gtcgctgtcc gcactcatca gtaccccaaa gaaaaggact
      841 atggaaaaga ggataggaaa cagactgcca atgatagcga tatgtttcaa tttcattttt
      901 tcttctgtcc tttcttcgtt acaaggttac ggttcttttc agtatgttct gttgtacgct
      961 ttgcttgttc aactgtttgt gcctttgtgg tacgttctgc tttgtaattc tggtgtgttt
     1021 catgcgatac cactttttct acatttttac tatgtactgt ctgtgccgat tgtggaattt
     1081 ttccgtcaga tgtacccgaa gataagggac gttctttcac actatttgtt ttgactggct
     1141 cgcctgcttt ggaagttgaa gttgtagcag gacgtttgac ttcctgtgtt ttctcaacat
     1201 ttgtttttgg aatggctgaa gctgtgactg gtcgctcatg gggacgggta gctcccgttg
     1261 tcgctgatcc gtccgtcttt cgtgcctgcc ttgcttcttg tgctttttga agttccatac
     1321 gcttgtcagc gatattcttc ttatgctgtt cctgcttttc caagcgtccc gactgtctgg
     1381 attgttgttc ctgcaccatg ccacgcttga agtccgatac acttgttttt gctttttcct
     1441 ttgcggaatg gacggcataa gcggtctgtg tcggtatatc cttgaccgtt tctttcatag
     1501 cgtttgcctt gtctttgacc ttattcttcg tatctaagac agcacccacc tttgaaccag
     1561 cacgttgtcc catgctggaa gatgtattcc ctcggttgtc ttttgctgaa ttattccttg
     1621 ttgtccttgc attagaaacc gtactgccag ccaccgcacc agcaacaccg ccagcggtaa
     1681 cagcaccagc aagccgtctt tccatacgcc tagccctatg tgccatataa agatacggtc
     1741 tgcggaaaat tcttcgtccc atgctttgac tgtcgttagc gttcaaagag aacatactca
     1801 ttaaatcgcc taacttcatg tagataccag cgaaacacac tatctgcaag aacgccacca
     1861 taaagaacgg gtagtctgtg gaaatgttat aaaacatact ggaaatgcta aatgccaccg
     1921 ttacaatgag cgtaattcct gcccttgtca ttatggtatt aaataccctc acgattgcct
     1981 gctttgccat gctttcatag ctcggtatca tggatagtaa aaagctgata ggtaaaaaca
     2041 tggcgaagat aataaaaagt atctggctga acaacatcat acccgtaagc aagaatacaa
     2101 atatcgtgat acctaagttg aagaacaaga ggaagaacac catacctaaa cggtttacga
     2161 cttgcggtat cgtcagattg ttgttgtcgt tactttcgat ttctgttttc acgacttcct
     2221 ctctggtttt gccgtcctcg ttctctgggc ttgccgatac aagagcttct acacggtctg
     2281 tcccgatttc ctctgcgttg ctgttcccaa actgtaagag tagccacggc tgttccactt
     2341 gaatagagaa taggctgtcc cttatcaagt ccacgctgtc cttgccctcg ctgtcagagt
     2401 ttgggagcat gatttttgtt cccaagtcca aagaagcggt actgatgtcg cttgaaaatt
     2461 catttatctt tttgatgtag tcgggagcat aggcaataaa tgaagccgac aaaataaaca
     2521 ccacaacaaa gttgataacg gcgtgaagtg ccttgctggt ttctctttta atcagtcccg
     2581 tataggcaac atatagtccc accactaaga taatgagaag caggaaaccg acatagaagc
     2641 cagaggttga aaaaccgctt gaggtaacgc ctgcaagggt ctgtatgctc tgcccgatac
     2701 tgtctgccat atcattgatg aagtccagct tgtaggcttc ctgcactaca tagcccgtgg
     2761 cattacttaa atataaactg atagtccaga caaaattagt gatacagtac aaaccatatt
     2821 gtactgattt tccaatcccg tccagccagt tccacggcaa ccaagcccag ctattatcca
     2881 catagaagtc aagctgatag ttggaaagcg gatatttgga atatagattt tctgcgttta
     2941 tcgtatcgtc cacaagcccc gtcgcatgag ccaccgtccc cagaagtgaa agcaggataa
     3001 gggagagtgc caccacgaac agagccattt tgagaaagtg gaaaatcttc ttttttgtga
     3061 acgcactctg tatcctttct ttcatcactc cacctcattt ctctgtatag gcggtctggt
     3121 atcaaaggcg tgtagcagtt cttcaaagac ggggtgtatc tgtaccacgc cgacacgccc
     3181 gtataagtcc tgcaacaagc attgtccgtt ctccaaatca cgaagtcgct tctgattgtt
     3241 ttcgtcctct ttgtcgatac cgaaaaattc taaagtctgt tttatctcgt tgatgtcagt
     3301 agaacggaaa gcgaatttta agccgatatt gtttttcaga ctttcctttg acacgtcccc
     3361 agaagattgc gtaacgaaat acacacctgc ctgcatagct cgtccagcac gcaccagctt
     3421 gttagataaa atttcgcctt gtgccacatt taagaacgcc cacgcttcat caaggtctac
     3481 gattttgaag atagagcggt cgctgtggat aaaatctaag gcaaaggtac taatcacaat
     3541 cagcatggaa accgatagta attcaatggt cgtgtattcc tcaaaagtcg tgtccttatc
     3601 tggcagtaca aggtcggcta cttgaatgat attgagctga ttatctaaac tgatagcatt
     3661 ttccaccgtt ccgtctgaaa acagaagatg tgcaaaatca tagtctgtaa agctgtcgat
     3721 atggtctgcg atattgcgtg aaattgcggt atcttcacag cgtaactcgt ctatcacatg
     3781 aagcaagccc cttgtttcac tctgggtaac agaacgcacc gccttacgaa gtacggggaa
     3841 tttttcgccg tccctagagg aaataccagt taaaaaggtt agtatgtcga ttgccagact
     3901 ttcagcgtct ttcacattct tcataatcac aaacgggtca agaagccctg cgttgtcctt
     3961 gtcgcttgtt aggtttacga tattgatttc atgggcgatt tctggaagtg tttctttcca
     4021 gtttccacgc tctgattttg ggtctaagat aaccgcttga ccgccaaaca aaacagaata
     4081 gtacacaagc aggttattac agaatgactt cccaccgcca agcgaaccaa caaaagcaga
     4141 agcaagggca tttgtaactg taccttttac gccttgactg gcaagggacg gttgcagata
     4201 tacatttctt cccgtatcaa cggaatagcc catatagata cccgtgtttt cccctaactg
     4261 ctgtgtcgca ccaaaaccaa gcccagctaa gaagtctgat tttacatact gcacataatc
     4321 attgatatat cgcttgctgg ctggtagaaa ttcagaatga agccccagca tatccccagc
     4381 aggacgtact aacttcacat tcaaatcgtc ataaaaatct ttgacttcat cacaacggcg
     4441 tttcagttcg tccaaatcat cagcagacac acggataaca taagagagct tatacatact
     4501 ttcttttgtc tggtctaaat cggtttccag ctcgtccacg ctgtctaaag cgtctactac
     4561 atttgagctg gtttcacttc cagcttgata agcgtgatta tcaaggtctt tcagttcctt
     4621 tttcttgttg cggacggtcg ttaatgcttt tcggttttcc acgatttcta cattcatgct
     4681 cgtatcaacg ggaaaggtaa attgctgttg ctggaaatag aagatttcac tagacggaaa
     4741 atcaagctcg cctacaatcg cattgacggt aaaataggac acataacttt ccttgtcctc
     4801 atgttccaat cgtaaatatc gctggctttc ctcaatcaca caccttgtcg ggcggataag
     4861 gtcgtaatac ttgataagtg tttctttctt atactttttc tttggtagct ggtgctcata
     4921 atcttcatag gcgataccgt ccctgccgta aagatgttcc ataagatacc caaagtcatt
     4981 gatttccaga cggcgaacct taaagcgacg ggagatttta ttttccagta acttttccat
     5041 tttcatgtaa cggttgattt catcattcgg catggaaaca aagtcgttca tcagcgtgtg
     5101 gttcacttca tggagaaact ctttgaacgt cagccacgcc gattttttaa ggttcttcag
     5161 attgagctgt tcttccgtaa ccatgagttt aaagccaaga aaaaagcggt agtccacttg
     5221 attgtcccca atcattgata ctaacgcttc ggtctgttcg tctatcttct ggtaagcgac
     5281 ttcctttaat ttccccgtaa ccaatctttt tgactgctcc tgcatacttc ttatagagct
     5341 ttccgtggca atctgcaaag catgaatttt accctcacgg gactgtgcga ttagctgtcg
     5401 gaaactgtca tgcacgataa atttctgttc tgcggataag aaagaatagt tatacggtat
     5461 cagctcatag taggcgaaca cctcattgtc cttgttccag acaaggttgt tgtcaatata
     5521 tttaatcggg aacataactc acactcctta ctgccgtgat tgtttcgttg aatatttctt
     5581 tttgcagttt tacggctttt cctgcataag tgattttcgg tcgcaacgca taggttatct
     5641 gtgatttcaa aaagctgtat ggcttctttc cgtcaaaggt tttctgcgac ataaaccaag
     5701 tgaggaaagc aggaataccg aagtatttta aaaatgctcc ctcaatcatg gaaagtgggg
     5761 gcatatcccc aaacagaatg atgataaatt ctgtaatcac aaaccatgta atctgtgtaa
     5821 aggtaacggg aaagggcaag ttaaagtcat tgattgcata caagactttt tctacattcc
     5881 agatacccgt gtagcttcta atctttttca agttctttca actcctctca taagtttcta
     5941 aatggaaaag gacagccctg tttcagactg tcccttaaag agaaatacgc cgtcagtagc
     6001 aacaatgctt gtcgctgatc ttccagcgtt aatatggtat ctcgcacatt cctcggcttg
     6061 ttgcaatgaa gcaaccgccc atatccaaat ctcgcccgta tgcttcatag tcaatatagt
     6121 tctgcaagct agggggaata tcgccaagtg cctgcaattc atctatgtag taataggcaa
     6181 catctgtcat ggtttcacag tcgggataat agtaaatatc gtccttgtgt tccacgactt
     6241 cctccagcgt cccataatga ccaataaatt cgtccaaaca atccacgata tagtcgggaa
     6301 gttcctctat catttcatac atttcattga gttcatcaat ggaaacatac tccccaatct
     6361 caatcgggaa gttatcggta tcatggattg cgtattcttc atactgttca ttcaagccga
     6421 ttttttcttt cacatcttcc tcgtcaatag ggaaagtaaa ccaagcaccg actaaatagc
     6481 cctcattata cttgccaaga ttagcgatat aaactgccat atcatcaatc atacttactc
     6541 tggcaattca aagataccgt gttccgttac taaaaatttc ccgtgttcct gcaagtgtga
     6601 agcataggtt tcaaagtcaa aatagtattc ttgacagtcc tcggataaat gtttgaatgt
     6661 agggtcattc atcagctttt gccttgcaac atcaatcatg cttttacagt cgggataaag
     6721 cgtaattaca ttcctgcaaa tataaagtgc ttctaaattt tcatacaccg tatgaagcat
     6781 tgtatattct tcctgcatat cgcttgaaag ctggcgatac atataatcta attcattgag
     6841 ctggtacacg cttgtatgct catggacttc atcagcataa ggcaacaatt tttcaataat
     6901 gcggtaatct tgactttctg tactgacacc taacttttct tcaaactcgg caacctctat
     6961 cggcaggtcg aaccagtatg atgttgtttc ttcgccagtt gttcttttcg tttccaccag
     7021 tacccttgtt tcctgcattg ttcctcacgt cctttctgtt gtttcatcac atcttttaaa
     7081 gtctggcatg acataccaaa cacatatttt gaaaaatctt ctaactgttt ttcttcatag
     7141 tcggcaaggt tcagttgctt catttcatgc cacaccttac gcttgtaaga gggcaggtct
     7201 gaaatgtttt cacaaccaac ttttgcctgc atatctctaa aaatatcgtt cattacatca
     7261 ctccaatctg aaatttaggt aagaaaaaag cagtcaatcc taagactaac tgctttgtgt
     7321 gtatggatat gaagttgtca aactgggatt tatctggcag acttgtttat ccactcatca
     7381 agaaatttca tttgttcttc cgtgtgaaac caatgctctc cgtttctcat aacagtaagt
     7441 gttgcattag tttgttttgt aaattcagat atagttgcat aagaagtcaa gttatctttc
     7501 tcaccaaata aaatatttgt tggaattttc catgtagttg gattttcttt tacataacag
     7561 agatattccc atgagagtgt ttctccaaaa gttgttttaa tttctttttt atctcgaagt
     7621 tcatcttctg taacatttgc ccaatacatc atatctgcaa tcagtttttc catattcaca
     7681 ataggtgaaa taaaatatgc tttttctatt tgcttatctg ataaggcgtt catagcgaaa
     7741 taggcaccta tgctatttgc aactatttga acagatttgt aatgtttgca aatcaaatca
     7801 aaaagtgatg gaaattcttc ttttgcttcc catggatatt gtgcagtata gttgagtcca
     7861 accacatcac aatcactaaa aagaggtttg taatgtgaag actcctctgc atttccacct
     7921 ttaccatgta tataaataac tactttatcc ataatagttg tcctcctcaa cttcaaattt
     7981 gtcgctttct tcatatccac attatatcat tctcatatca gcaccacaat aaaattttac
     8041 gcaccgataa tcttattgaa cagctctaac agtacgtctt tcacaccgcc agcattgaat
     8101 accaatccaa cggcaacaag ggcaactacc aagaagccga taagtttaga aaactcacgt
     8161 ttgaacccta agtagatacc aataaccaca atcgccataa gcactaagct ctgggcgttg
     8221 cttaaaaacc atgtgtatat ggataggtaa gttcctgata ttataaatat ctcaaacttt
     8281 tccccccatt cacacggagc gtgcgacttt caacgcactc cgcgttccat cgtgtttata
     8341 ttgaaaagta tttatgtagt agacctatat caagtttaat tcttgattgc cagctaatac
     8401 tctatattta tttagtctta tgagctggac tttatttagc ttcaatagag ctatatattt
     8461 ttgtattgtt tcttctgttt tagcgtgtat tagacggtgt accgcctctt ttaccaaaat
     8521 atgattttta taatcgtcat ttccaccagc tccagttggt acaatatgat gacaatgtat
     8581 ttcattagct tgttgaaatt cttccagagt tatagcacat tttccatgtt gagcagaaaa
     8641 tagcgaaatt cgattgtctg cgtattctat tgtgcgattt tccaaagata atttcattaa
     8701 ctggtacatc agtaatttat caacacttag attggtgtgg ataaattttc ttccctctag
     8761 agtgtagcaa ttcgctaaat acacctttgc cattggtttt ctgtgttgga tatatccaac
     8821 agggaaaata ggttcgccct cgccagcaac ataccggagc attttagatt taccatatct
     8881 tgttgcctcc tttgtcgtaa gttgtctgcc tgtttttctc aatctgcccc ttttgtttgt
     8941 acctaatctg ttagtgaaga tagccattac agctctattc agtttcatac aatccagatt
     9001 tacattcgtt gcaatctgat aataattttg catacctaat accattgaat tataaagtct
     9061 tgtttcttct aattccgttt tcccttttga gggagaagca attttctttg cctgtgatac
     9121 cagcttgtct ttttggtttt tgaattgttt atcacttata tgtgatttaa caactaactt
     9181 ctttcttctc ggtatcattt taatcttgaa accaagaaag tcggagtatc tttttctaac
     9241 atttacaatt cttgtttttt cttgtgatac ttccaatttt aatcgttgtt caatccattg
     9301 agtgattgct attttggctt tttcagcact ttccttgtag cggcagaaaa ctctaaaatc
     9361 atctgcataa cgaaccatat acatttcctt taactttgtt ttcttcattt ctttgtaagc
     9421 gttgctttta catgggctac cgcttttatt gatatgaacc acatagtttt ttgtaacagg
     9481 attttcctgc cattggcttt ctacccaatg gtctaactca ttaagaacaa tgtttgctag
     9541 tagtggggat attattcccc cttgcggagt tcctttctct ggatatgtta ttgtaccgtt
     9601 agtcattttg attggagctt ttaatatcct ttttaaaatg aatatcaagt gcttgtcccg
     9661 tattcccata gcccatatct gttttatcag cttggaatgg ttcacgttgt caaagaaacc
     9721 cttaatatca aattcaatca cataatgtag ctggctgatt tgtaggcggt tataggttgc
     9781 ttttattgca ttttcaactg acctattagg tctgaaacca tagctgtttt cactaaattt
     9841 agcttcgcag attggttcta atacttgttt tatacattgt tgtataagcc tgtcccacat
     9901 acaaggaata cctagaggtc tggttttacc atttggtttt ggtatttctt ttcgcctcac
     9961 tggcttaggt cgatacccat gtggactgcc tgcaacaatg tatcttactt ttttgacaac
    10021 tgtttctgct ggcaatttgc caatatcttt aattattgta ccgtctgttc ctgctgtttt
    10081 actgcctgca tttgctttga tatttcgata tgccagtaat atattttctc tcgataggat
    10141 aatatccata agatgagtga aaatatctcc attcttactt ttggcatata aatcatcaaa
    10201 ggtgttttgc atttcgtaat attcagcgtg tcttaaatct tctacacaca atgtttcatt
    10261 tttattttta ggcataaggc ttcactcctt tgcttgaaat tgagtgagct tttttatctt
    10321 actcgtaatc cttattgaaa caacataata cttttctaat atatacacga cttgagggca
    10381 ttcctccatt ctcattacaa gaatttctta ggttcgccct ctgcttttca gcattagttc
    10441 aactgcttat tgttcttcgt cagtttattc tcttgatgag aacccaatac ctttcctcgt
    10501 tccgataatc ttatctatac atatatatcc ttaggtcact agctataagc ctgctggctt
    10561 gataccgcct gtaacgttat atggcatttc ataacctata ttcttacttt gccacaccag
    10621 ctacgatttc tcgtaccttt gcatttctac aaagttcaaa tttagacccg tacattcgct
    10681 gtttcgtcag ttccttatag aacattctaa ccatagatat tttatagacc cccgacctgt
    10741 tggatacgct acccgcctct ggatagtttt cgatagaaga tatatgttca tcaactatta
    10801 cggtatcttt cagccgtctt taccgagctt caaacattct gagtttcctc atacaatgct
    10861 tgtcggaggc tcagggcagg cgtttcagag cgttacttca tcattccacc tgtcagatta
    10921 tcagttctcc taataaccaa actttttcgt tcttttatta gtgccttagc ttttcactaa
    10981 ggaacgagtc gcacataaat tttgtccgaa attcatttaa ttgtcctctc tttctttgat
    11041 ttcttccata catctgtcag cttctttgcc gacagttaaa atgcacatca agactacacc
    11101 gatacccatt ccaaatgata ccagcaataa gtctttcaat aattcccaca ttttttcatc
    11161 actcctttac gttggcaacc atttcttcaa ccgtggctgt ctgttgcttg attatctggt
    11221 agtgtcgttc ggtcagtttt gcctgctttt caatcgtttc cagatactcc gtctgattgt
    11281 ccttgtctat ctgcttcaac atcttcaagg tcggtgcaac ctgcctttgt agccagttga
    11341 gtgtacgctc cagcgtgtaa ggttctggct gtgttgtcag ctttacgggc ggtcgcccct
    11401 cgccaatgaa ccaagcccag cgtacattgg ttttccagtc gctttttcgc ttgtctggtt
    11461 ctttatcagc gaagcggata tattgattga taatagaaaa tgctgtcagt tctgcgtcat
    11521 aatgtgtcag cagttccaca acagcataat aggcacgttc atttttcaaa cgtatctcaa
    11581 atctattttt tatggggact tcctcaatcg gtatgccaag tttggcgtac tgttcgtaat
    11641 tcttttcata acagcagaag tacacttcac ttgaaaatga accaatatac agcgtgtgtc
    11701 ccataccgta tttatccgtt tcattatgct ttaccagctc tccagaacca tagcttttga
    11761 aagaacggaa tttagaaata cattcctcat tctcgcattt tcgtatcagc tctggaatat
    11821 caagtaagcc cgttcggtca ttgattgcca aatcaagacg cttcattaca ccgccctcaa
    11881 ccaatgcgtc cgtgaagaag tcataccaac ttcgctcttg tgccagcaga tagctttcaa
    11941 actggcgaca gcctttgcct ttcagttcca gcaggacacc tttttcttcg tcctgcgata
    12001 catacacaaa cacatctccg atatggtaat gctcggtgta tttgtaatgt ccgtaatctt
    12061 cgtgaagcat atagccgatg ttgagcttca atatatcctt gatgatatgc tttatatcca
    12121 ttgtgggaaa acggatacgc acataatcaa acagcaggaa catgggattg ttgggattga
    12181 atttttccac cgcttctaaa agcgtatgtt tcatgtcctc ggtcagcgtt acctttcctg
    12241 cttcgatacg gctcaaatgt tcacggctga tatttgccat gattgcaagc cttgtctgcg
    12301 atacgccgta tgcacagcgt ttttctttca aggcggttaa aaaatcagtt tcattcagtt
    12361 gtcatacccc caatcgtgat aattttgtga tattgtgata atttcaaggc tttatcacaa
    12421 aaggcgaaat gtacgaaaaa cccttatttc atgcggtctt gcaaaggttt ttgtggaagt
    12481 ttccgccgta attgtgcccc tctgttagat aatgaggggc ttgtatctgc tggcgtggct
    12541 aacgccacac cagcaacggc tagtccgtgc cgtcgccttt cgcttcgcac gtcgccgtcc
    12601 cgtcctgcct tgcgtatgca agtgagccta tggtctgcaa aaaatcatgt ccttttggaa
    12661 ctaagggtgt gtaaaattca cttatgacgc ttgttcccac atcacaatag ccacgtccct
    12721 tgatacgctt ctggaaaaac tgttttttca catcagaact gaacagcata ccgtaaccta
    12781 attcgctgat acgccccaag ccaacacgga aattaaaatt atctctgata ccgtccgaga
    12841 aatattttgc gtctggacgc tggcaggcaa caataaggaa atatcctgct tgtcgtccta
    12901 acatgacgat tttctttagc tggctaagta ggctcacact ttcttttgtc cccagcattt
    12961 caaaaaacgc cacatattca tcaaagataa gaaagcaggg cggtaaacca agataggcat
    13021 agttttcgcc cgttttatag tctgggtgtc gcttcatttc ttcgcttctt tgtaccatgc
    13081 cctcataaaa ggcattgaca caatcaatca tttcttcttt ggtgtgatac acatttccca
    13141 ttaccgtacc taaatctgca aggtcagcgt tcttcgggtc taatatgtaa agaacagcgt
    13201 tcgtatgtaa cagagcttca ataagcgtca gcagaaaata cgttttaccg ccaccagtcc
    13261 caccagcaat cagagcgtga gggagtgcgt catattccca tacaagattt ttcatcagcc
    13321 taagacagcc gttttctgct ttcacttcat caatggtaat gcggttcgct atcatatcat
    13381 aaagcatggt gtattcgata taaccgtcat gtaacgtctt gtcggtcagc tcacaataca
    13441 agccactttc caatttatcc tctaaccgta agagctggtc ttgatatttt cctaatgtaa
    13501 tttcacagcg gatatgaagc agtccttttt ccatttgata ataaatcttt ggaaaccaga
    13561 tgattttttc ccttgatctg ctttgcaggt cagtaaaaaa accgctgtct tgtacggtgt
    13621 ctgcttcata ccacttgttt tccagtatca ttcgtgccag cttttgacgg tgcaggagct
    13681 tcttgaaact gtcataacag aagcggtaat acagaaaagc gaccaatgca caaacaccag
    13741 tcgctatcag tagggttatg aagttgtaag tggaaagcgt caaaccgttg tctaataagc
    13801 tgaaatgctc ccaatcggta cgcatgagct gtttcatatt cagtagcagg ataaccgcaa
    13861 tgaatacaaa cagaagcgtc cctatggaaa agtggtagac aaggttcttg tcgctggctc
    13921 tgatacggtg tcctttgttt aaaatcattt tcataaatca atcactcctt tctgggtacg
    13981 aaaaaagcag tcaatcctaa gactaactgc tttgtgtgta tggatatgaa gttgtcaaac
    14041 tgggatttat tgttcttaac ttttctgtcg ttataaagct gacttacgca cattaacctc
    14101 tgcacagacc agcccagcta tatgctccgc tgtttcattt gtcagtacaa agagcattcc
    14161 gtcattacgg cattttttat gtgtgtcgcc attcaaggca taaacaaaac cttttacaca
    14221 ggtatcacta caggcattag ggtcaatcag tctcttgcag tcacgagaag tagtcatttt
    14281 cttttgcata tcagcaggaa gcgaagcgat tatatcctca tactttccag cgttgtctcc
    14341 gtaaatccgt gcaaaaacac ctgtcttgcg aaacacccaa ttcattactg ttttcttctc
    14401 tagttggtat gaagcggtgt aaccgctttt tgcttccttt attacaaggt cacagccctg
    14461 ctcaataagt ttggtattaa gtttctcgac aaacgcttgg tgttctggcg cgattgccga
    14521 tagaaattct ttgaatgaac ctttttcttt tgccattatc tttttcctcc acaaatttca
    14581 atttatccgt ttcttcatac acatattata acagttgctt atatccgcta caatgaaaat
    14641 ctagtttgcc agcttatttc tttggttgcc cctgcggtgc atggttctgt ggattgccta
    14701 cttgaccgcc tttattcttc aagataatat cgtcagcctt gatataccag tccacattga
    14761 cacctcgata gctggcgttt gctaccgtat cggctacggg attgacaagc tctacctctg
    14821 cattatacgg atagtccttg acgggaatat cagcaggaat tgatacttgt atcatacgtt
    14881 cctgcacact acatttcaaa tcataggttc ttcgtgtgat ttcttcactt gttgaaccgt
    14941 cgtcattttc tgctcgcacc tcatgtctga gggcagagaa cttcaataca ccgaaagttt
    15001 tttccttgtc taatacaata ccgtttgcta atctcataat catttacccc cttacttgct
    15061 ttcctcggct ggcaacatat catcagccgt taagatatag tttgtgaacc ctcgtccttt
    15121 gaccgcttta ccgtctgcgg taatctttgg attgataagt tttactcgct gttctggttt
    15181 gaaatgcttt tcgcctgctt tcgctggaat ggttacgata atatcatcag ccctttgtac
    15241 gtcagagtac aagttgtagc ttcttgatac gggcgtaaag cgtccgttaa tgcgttgctg
    15301 ttcaatcttg ttttcgccag caaattccaa gtttccaaaa gtctgtgcca tgttcggcac
    15361 tacatatttt aattccatag tgttttacct cgtttctttc ttctttttta agtttgttga
    15421 ttgtgctttc ttattctggg aattagggaa ataccagtaa tcccccagat agtaaagggt
    15481 aaatcaatgc ttcgcaccct tgactatccg tgtgcttgca ggttgttggc agacaagcca
    15541 gaataagtaa acgtctgccg tttgacagct tcggcagaga gcgtgatttt tcttttctca
    15601 taccgttacc gccttatgat ttcttcattt tacggcgttt gtaaagatat gttccagcca
    15661 gtccaccagc agatgtaagc aacattacca gaaatgccat gacatttgtg ttgtcgcccg
    15721 ttttaggact gtctgttggt ctgctcggtt tttctggtgt tgttggcgtt tcgggtttct
    15781 ctgggacttc tggtttttcc ttaaaagtaa tcgtctgtcc ctcgtcctca atgtccttat
    15841 gctcagtaac ttttttcggc tcgtttggat tgcttaaatc atacaattct tcaaaagtta
    15901 caagctgttt gccgtcaaga gaagtagcgt caaaggtaaa ggtaacttcc actttcatag
    15961 tttcgctgtc agcgataaac gtataatcac tttccacacg ttttccattt ataagaagct
    16021 ctgcattttc ttctttcaac atctgccagc ccacaagttt atactttgta ccaacttcca
    16081 agccctctaa ggttacagta tcaatgattg ttacgtcttt tcctgcttca agctctttgt
    16141 taccgtcctt atcggtagca gttgtatgta ttttgatgat acgttctgta ataagtaccg
    16201 tctgcccgtc gtcctcaata tctttatgct ccgcaacttt catgggttcg tctggattgc
    16261 ttaagtcgta taattcctcg aatgttacca gatttttacc gccaagctcg gacgcattga
    16321 atgtataaga aatttccact ttcatttctt catcatcagc aacaaaggta taatcgcttt
    16381 ctacacgttt cccgtcaatg ataatctcgg cgttttcttc ctttaacatc tgccagcctt
    16441 ttaactgata cttagtgcct tttgtaagtc cgtctaattt gacagtatca acgattgtta
    16501 cctcttttcc tgcaaggatt gtcttttcgc cgtctttact ggttgctgtg gtatggatag
    16561 tgatttcctt ttcgtattca tcagtcaaag tccctaaatc aatcacaaga ttatttcttg
    16621 ataccacgat ttcaaatggt gggataagtt ccatgccttt gttgctgtca gagcgtaatt
    16681 cttcaataat gtaagtatcg taaggcaacg cacctttgct gtcgtctggt tcagaagttc
    16741 caaaccatac accgtcctcg cttgttttgc cagcgttggt attgtgcttg tgcgaagccc
    16801 attttgaaga agtggagaat tgcccattat cgtcagttac cacaacatga ctttcgcccg
    16861 ttgtcttgct tgtgatccta aagggaacat cagcaagacg cttgtgtgtg cctgcaccga
    16921 ttttcacgcc ctcaatatcc ccacgcttaa tctgattgta gatagagtgg gcttcgtctg
    16981 ttaagtccac gatttttccg ttttctgtga ttgtaaaatc aatcggcttc gcaccgtctg
    17041 tcaagtaacc gtttggagct tgtttctcaa cgatacggaa attcccgtaa ggcaaaaggt
    17101 cagcagaagt agaagcgata ccctcaatat ccgtatggat tgtttttaca acttcgtttt
    17161 tcttgtatat cttgccctca accaataccg cattatcatt taaggaaatg atgtcaaagg
    17221 cagtatcttt caaagtggca cttccttgtg gtttggtatc tttggtttct aaatctcgtt
    17281 tctgaatttt gacaccgcca cgaatgactt tatctgatac ggaaaactgg ttacttccag
    17341 ttaatacggc aaggtcgccg tcctcggtaa tctgcgtaag gtataaggct tttatctgtt
    17401 cttcactacc attcgcctgc atatatgcac cgtctagtaa gtagcccgtt ggcgatttcg
    17461 tttcttcgac cgttagtgta ccaagaggta aaaacgcttt tccgtcctgc atatagaagc
    17521 tatcgccaga taccttgtat gcgtctgcta attttgtgat gtaatgggtt gtcccgttac
    17581 tgtctgtttc agcggttgtc tttgtaaccc atgtacgagt agcttcggca ggaagattgt
    17641 ctttattgta gaagcctgca taatatttcc atgtaaactc cgccccctct aaagaagcgt
    17701 tcccttgtgg gttggctttc tgtgtttcca tgtcaatttt aaaaagctca atcaaagtat
    17761 cggtaacttt tggcgtatca gatactttca aagtcgctgt ctttccagct tcgactttta
    17821 aggaatacac cgtagtatca actttatacc ccaatggtgc agataattct ttgatatata
    17881 cggtagtagc tttgacttct gcaacctctg tatttccgct gtcgtcagtc gtaagggtag
    17941 caatctgttt ggtgcaatcc ttatcggaaa agacaccgta agtcgcacca gcgatagagt
    18001 aatttccgtt accgttagta atgctggtat tattggaagt cttttgaagt ttggcatttc
    18061 cgacatttaa cttcgcccag aattgcccta attcctgccc ctcgccagag tagatataac
    18121 cgccgcattc atagcgtcct ttgttttctt tcacaaaggc ttttgcacca gcaaacactt
    18181 catcttgtgt tgcctttggt atttcatcat aagaagctcg cacgttatca cattgccagc
    18241 ctaagtgaac actcaatctt tgccacacaa caagctgtct taaaaggtag gcgtgatttt
    18301 tgcttatccc attgtggttg tcggtgtatt gcttcacata ttcgatagat aaggcaacat
    18361 cacttatctg gtcggcactc atacgggagc ttgcgtcagc tctggtcttg tagccgttct
    18421 taaaatctgt gttaatatcg atacaataag cgtcctcgcc ctcaacggtc aaatgcccct
    18481 cgttaaaggt agaaccaatc gaaccgtcat tcattacttt ttcaacgata ccgacacgtt
    18541 cttcactttc cgtccagtat tgcttgcttt ctgcatggac aagtgtagtc ggtaaagcag
    18601 taacgacagt cgcaaaggca agtacgcccg tacacaatcg tttcaatatc tttttcataa
    18661 ttctaaatgc tcctttcatt ttgggtaata aaatagccgt ccataatgaa cggctggaaa
    18721 tagaaaagga acgtcaattt aggcgttcca tagtctatga aatattcaat ttttttcttg
    18781 cttcaatact gatgtgccgt accatatctt tgcatatcta ggaaaacttg cgtatcaagg
    18841 ctcattcatt ggtagtaaat tagtagtaaa ttgatgtgtt tgtttccttg aaaatgctga
    18901 tagatactat gttttagcgg ataatcaact ttttagtatg ttttttgcat aaaaattgag
    18961 tagatagtag ttttattgta cttaatgatt gtatttaagt gattagattt gaaattgaat
    19021 aatgtagata ataaaaaaat attaacagaa cttaataaac tccattaata tttttttatt
    19081 atttttgaaa ctgtgataat tattacggaa gcatagaaaa taaagtgtta agatttaaac
    19141 aagatagtaa gtaagtaaaa ctaaaatata agaaaggtga taaaaatgaa actaaaatta
    19201 gattcatcta agttcaatga aggtctgaat tatctaaaaa aagactacaa gatatttgca
    19261 ccagttttaa taccatttaa aggtactttt tcagatactg atgttataag atacaaggag
    19321 gtaaacgctt ttgaagaaat ggaatttgct aagaaagcaa acttttcacc aaaagatgtt
    19381 gtacttccca taaatcaagt attgttttat tttactgaaa aagagtttaa ggaaagcgat
    19441 ttagacaaca agaaaatttt aattttctta agagcttgtg acataaatgg tataaaaaga
    19501 cttgatgaaa tatatctaaa taatggtgaa gaaaaagatt atttttataa aaatatcaga
    19561 gataaagtaa agtttgcact tgtagggtgt aaggaaagtt ttagaaactg tttttgtgtg
    19621 agcatggatt ctaacaaaac tgataattat tcaattggat taaatataga aggagataca
    19681 ctgtacttag atataaagga tagtgaattt gaagtattta atggagaagc aactgaattt
    19741 aatgttgatt atgtaactga taatttaata tctgtagatg tgccagagaa tattgattca
    19801 aatgaaatga taggaaattc aatatgggat gaatatgata caagatgtat aggatgtggt
    19861 agatgtaatt ttgtatgtcc aacatgttca tgttttacaa tgcaggatat tttctataag
    19921 gaaaacgaaa atgtaggtga gagaagaagg gtttgggctt cttgtcaagt agatggatat
    19981 acagatatag caggtggaaa ttcttttaga aaaaaacaag gcgaaagaat gagatttaaa
    20041 actatgcata aaatacatga ttttaaaaaa agattcggat atcatatgtg tgttggctgt
    20101 ggaagatgtg atgatgcctg tccgcaatac atatcatttt caaagtgtat agaaaaaata
    20161 aatgatttag taattagtaa ggaggaagta taaatgaacc catatatacc agtaagtgca
    20221 aaaatactag atatagttaa acatactgat aaagaatgga cttttagagt aaactgcaat
    20281 acaaaaggtg tattgcctgg aaagttttat gagatatcta tacctaaata cggtgaaagt
    20341 ccaatatcag tatcaggata tggagaggat tatattgact ttacaataag aaatgtagga
    20401 aaagtaacta gcgagttgtt taattataaa gaaggagatt ctttttttat aagaggtcct
    20461 tatggaaatg gatttgatgt atccctttat gaaggaagag aaattgtagt agtggcagga
    20521 ggaagtgcat tagcccctgt aagaggaata gttgaatatt tttataataa taaagaaaaa
    20581 tgcgaaaagt ttaaattaat agtaggattt aaatcaccaa aagatatttt atttgcagat
    20641 gatttaaaga gatggagtaa aaaacttgat attttagtta ctgtagatgg agcagaggaa
    20701 ggatatagtg gtaatgtagg attagtaaca aaatacatac cagaattgga tatgaaagat
    20761 ataaacaata cttctatagt tgtagttgga cctccaatga tgatgaaatt tacagtagaa
    20821 gaatttttaa aaagagattt agatgaaaag aacatttggg tttcttatga aagaaaaatg
    20881 tgttgtggaa taggtaaatg tggacattgt aaaatggatg atacttacat atgtttagat
    20941 ggaccagtat ttgattattc atatgctaaa aatcttattg attagggggt gaagtttgtg
    21001 ataagagatt taaataccaa aaaagtaatg aaaaatgctt atagaattac aaaaacaaaa
    21061 tatgagactt ctttaagagt tagagtacct ggaggtctta ttgaccctga gagtttagct
    21121 gtagtttcta aaattgcaag tgagtacggc aatggacagg tgcacataac tacaagacag
    21181 gggtttgaaa tattaggaat aaatatggaa gatatggaag aaataaataa aattatacaa
    21241 cctgttattg aaaaaatgaa tataaatcaa agtgagaaaa acgcgggtta tccagcagca
    21301 ggtacaagaa atatagcagc ttgtatagga aataaagtct gtccaaaggc tcaatataat
    21361 acaactgaat ttgctaaaag aatagaaaaa gctatatttc caaatgattt acattttaaa
    21421 gtggctttaa ctggttgtcc aaatgattgt ataaaagcta gaatgaatga ctttggaatt
    21481 attggtatgg ctttaccaat atatgaaaag gatagatgtg taaattgtgg agcatgtgta
    21541 aaaaaatgtt ctaagatatc tgttggagca ttaaaaacag aaaataataa ggtggtaaga
    21601 gataaagata agtgtatagg ctgtggagag tgtgtactaa attgcccaac aaatgcatgg
    21661 actagagatg agaaaaaata ctatagatta gctataatgg gtagaacagg aaagaaaaac
    21721 cctagactag cagaagattt tcttttatgg gtagatgagg acagcataat aaagataata
    21781 cttaatactt atagatatgt agaaaagtat atagataaag atgcaccagg aggaaaagaa
    21841 catataggat atataattga tagaacagga tttatggaat ttaaaaaatg ggcacttgaa
    21901 ggtgtagagc ttccagaaat aactaaaatg tacgaaaaca tatactggag tggaattaaa
    21961 tatctataaa ttgagtaaaa catatatttg aataaattaa aatttaatag aaggaagagg
    22021 gagttatgca taaagaaact ttggataaat taactaatgc agctataaat aagataaatt
    22081 tattaaacac aagtaaagta aaatatttgg tatcttctgc gtttgcagga ctttatgtag
    22141 gtataggtat acttttgata tttactattg gaggactttt gactgatgca ggttcaccta
    22201 tgactaagat agtaatgggg ttatcatttg caatagcact aagtttggtt ataatgacgg
    22261 gaacagagtt atttactgga aacaatatgg ttatgtctgc tggtatgtta aataaaggtg
    22321 taagtataaa agatacttct aaaatatggg catacagttg ggtaggtaat ttaatcggag
    22381 ctttggtttt aggcattata tttgtaggaa ctggtctagt agacaaagga cctgtagctg
    22441 aattttttgc aaatacagca gctagtaaag catccatgcc atttacagct cttttcttta
    22501 gagggatttt atgtaatatt ctagtatgtg tatcagtgtt gtgttcgttt agaactaata
    22561 gtgatactgc aaaaataatt atgatattct tatgtttatt tgcttttata acatcaggtt
    22621 ttgagcatag tgtagcaaat atgacaattt atagtgtttc attattttca ccaacaataa
    22681 gtacagttac tattggagga gctatttata atttagtagc tgtaacactt ggaaatattg
    22741 ttggaggagc tttatttatg ggtcttggaa cttatatatt aggtaaagaa aagcttaatt
    22801 aaatttattg tataaattat aactctcttg ataaatacat ttttagtatt gttgagagag
    22861 ttatttttat atttttgaaa aaatatttga aacaaaaaaa atatgggagc atacgaaaat
    22921 atatcggtta tatatataaa aaatacgttt atatatgaat tatatagttc taaatataaa
    22981 aaaagttaaa gtcctaccgt aaaaaagcgc attttgaata agataacaaa tatgataaaa
    23041 ttggtcttgt tgaaattttt aggggggata tgatgacaaa gaaactagta atatcaaaaa
    23101 caaagttgtt tatttttata atagcattta tttctatatt tatatattta tttggaagta
    23161 aaaatacact tataggtgta ggtatagtaa cagctatgct aacactcttg gaaagagatt
    23221 taactatttc tccaattaaa aatttactga agtatttagc aataaatata atcttaggaa
    23281 tactatcatt ttttgcagta caaaatatgt atttaggagt tttattaaat tttatagcat
    23341 tatttataat agggtatgta tttagttatg acttaaaaag agcagtatat gtaccctttg
    23401 gtctaatgta tatatttatg gtaagtatac ctgtaggaaa aagtgaattt cctatgagat
    23461 tgtcggcttt agctgttgga gcagttataa taatgattgc tcaatttgtt atgaatagaa
    23521 ataggatgaa aaatgtcgga gataaagaac tgatatctat atgtgatgaa ttattagaaa
    23581 aaattagcct tttaaaaaat actattaatg atgatagttc tataattaaa tctagtatga
    23641 gaaaaataga tagctgtaat tatagaataa attctatatc taaaaatttg aaaatggtta
    23701 tttttgataa tagaaaagat gacttttata tcagtattag aggtatagac ataatgaata
    23761 ttttattttc attagaaaga ataagtttaa tcctggaaag atacaaaaag gatagtaaag
    23821 aatttgaaga tgaagatata aaaaatattt tagaagaaag tagcataaat agtaaatcag
    23881 atgttttagt tgtagcaacg aaagaaataa actatattaa gatgtgttta gaaaataaag
    23941 ataccataac tgataaagag atattaggat ttagagatta tgttattgct caggatacta
    24001 aaaatataaa tttaaaagaa atttatagtg ttttagaaaa tttatatgag tttttagtag
    24061 attataaaaa agtaaaatca agagacgaaa agaaagctga aagaaaatca aagatacctc
    24121 atgaatttaa acgactatca atatataaga aaaactttaa tttaaattct ataagatttt
    24181 cttatgcagt aaagattgct ttagctacag ctgtagcggg ttttattatg gattatttcc
    24241 atttaagaga tggaagatgg ataatgttaa ctgtcttttc attaacacaa ccttacgcag
    24301 aaaattgtat acaaaggtct agaaaaagaa tagaaggtac atttatagga gctgtaatat
    24361 ttattgtatt attttcaata ataaaagata gtacattaag gtcgttaata gttcttttag
    24421 cagggtatat aaactcttat gtagttgatt atagaaaatt aatggtatgt gtaactgttt
    24481 cagctcttgg ttcagcagta gttatgggag acccaaatgt tttaacaata agcaggattt
    24541 catatgtagc attaggagca attattgcat taatagtaaa taagtttata ttaccatatg
    24601 atgctaaaac aggctatcaa catgttatag aaatgtataa aggaatagtt aaaaatataa
    24661 ttgatgaagt caataagtct atagaaaatg tagctgatgt ttactatata aaaaatttat
    24721 tattgatacc atcacttatt gaagatagac ttatgttgat aaatgctata tataaagata
    24781 aacatcaaga ggatttttta gaaaatcaga aattactaat aagtaatatg tataatctat
    24841 atataaatgt taataaaaat aaaataaaag atgaagatgt tgaaaaaata ttgagagata
    24901 ccaattatat ttcaaattac aatgtagata agtatgatga aggaagaagt gtaattttag
    24961 agagtattgt aaatactaaa agtctaggtg acaagataat atgtctaaac ttactgcaaa
    25021 ctctaaatgg tgtcaaagaa atgtatagaa taagtaatat aactaaagtt tcaataaaag
    25081 aagcagctta gatattaaat tatagaatag ccatatattt aaaataaagt atatggctat
    25141 ttgttttata aaatactaaa agaaaataat atataaaaaa caaaaaacat atatttatga
    25201 attttatatg aaaatagtta aaatattgat ttttttcatt ggttgaaaaa acaatttact
    25261 taggataaac tataatagta ttcaaatatt atgggggtta gatttatgag taaagatgta
    25321 aaggtaaagc gtaataagaa atatgataca tttagtataa ctatggaact tgagagacct
    25381 ttactttatg atgaggttga gaacaaagat gataaaaata ataatagaaa atttaacata
    25441 aagaataaga tatttaaggg aataggtata ctatttgtat tgattttgct tggctttttc
    25501 atatggataa ataaaacata tgaacctcaa aagctggcaa aagaagctct agtcagcaat
    25561 agtaaagttg aagtaactgt aaatgaaaac atttcattta caccaaaagg aagaaaagtt
    25621 tctaaaggtt taattttgta tccaggagct aaagtagaaa tagaatctta tgctccactt
    25681 gcaagaaaaa tagcagaaag tggatatgag gttgtaatcg taaagatgcc acttaatcta
    25741 gctatacttg gaactaataa ggcacagaaa gttatggatt cttacaacaa catagaacat
    25801 tgggtaatag gaggtcattc attaggagga gttgcagcat caaattttgc acgtgataat
    25861 aaattaattg aaggcgttgt atttttagct tcttatccaa tgggtgatga gttgaaagaa
    25921 ttaggaaaaa aagttatatc tatatggggg agcaaagatg gagtagtcaa ttttaaaagt
    25981 cttgtagaat caaaacaaaa acttcctgat gatacaactt atgttgagat tgaaggagga
    26041 aatcatgcac aatttggaga ttatggaaaa caaaagggag ataatgatgc tattataagt
    26101 caagaaaaac aacttaatat tactgccaat agtatcatta aatttttaaa gaatatatct
    26161 taaactaaaa tttaaaaaat ataattttat aagttattat ttaaagtaaa tattaataat
    26221 ataatagaat gaatatttta ttacaagggg gattttaata tggaatacga tatgccactt
    26281 tacagaccac caagtgaggc ttatagtctt ataatacaag tcacactagg atgttctcat
    26341 aacaaatgta cgttttgtag tatgtacaaa tctaaaaaat ttaaaataaa gccactagaa
    26401 gtaataaaaa atgaaattga tatatttaga agatattata agcatgtaga aagaatattc
    26461 ttagcagatg gagatgcatt gataatacca atggagaaat taagagatat tatcttatat
    26521 ataaaagaag tttttccaga gtgtgaaaga attactatgt acggctctcc taaatctata
    26581 gagaaaaaat ctgatgatga acttaaagaa ttaagaaaac ttggtgttaa aatgatttat
    26641 ctagggcttg aaagtggaag caatgaagta ttagaagata ttaagaaagg ttttagtagt
    26701 gaacaattaa taaaagttgg tagaaaagtt aaaaaaagtg ggattaaatt atcagccact
    26761 gtaatagcag gtcttggagg aactaaaaaa acacatcagc atgcagttga tacaggaaaa
    26821 atgttaggag caatttcacc agattatgtg ggtgtactta gtttaatggt agaacctaat
    26881 actgaacttt acgatttact taaggcagga gagtttacaa tactagagga taaggctgtg
    26941 ttacaagaaa ttaaagagat gataaagaat atagatgcta atgaaaaaat tgtatttaga
    27001 agtaatcatg catcaaatta tgctaattta aaaggtgtat tacctgatga taaacaacgt
    27061 ctaattgatg aaattgatta ctatctaagt aaccaaaagc taaaaagaga agaatataga
    27121 agactatagt ttttgatata tcaatctata ttgataggta aatactaaga ttatttagat
    27181 acaaaaaatc atgctacatt aatagttgct tactattgat gtagcatgat ttttttatta
    27241 aaaaacaaaa tggtatattc atatataata tatcaataat aatgaaaatg tgaactagtt
    27301 taatagaatt ttacctatta taataaaaac aggaatttaa ataataaaaa gtaaagtaac
    27361 tttttattaa gtaactttac tttttatttt atttaatgtt gtattaaatt tatatatatt
    27421 aaaataatat acaaattttg aaaaagctct tataaaatga ttattaaagt aaagtttaat
    27481 ataaataaat tataaaatat taaactaatt tatcaatatt tcctgattga atatgcttaa
    27541 tgtttgattg aattttttta tatggccaat cccaccattt aatttctaat aattttgaaa
    27601 ttgtatcatt attaaatctc ttttttataa tttttgcagg tactcctcca acaatagaat
    27661 acggtggaac gtcattagta actactgctc ttgttccaat aattgcacca tcaccaatat
    27721 ttacacctga cataattata gaatcataac ctatccacac atcatttcca attataatgt
    27781 tacccttatt gtcccaagcg tccgttatat ggttgatatc gagtttccat tcttcataaa
    27841 agatgggaaa agtatatgtg gattttgatt tcattgagtg atttccacta gtcattagaa
    27901 attttgcatt acatgctatt gagcaaaact taccaattat taatttatca ttgtttatag
    27961 ggtaatgata caatacattg tttttctcaa aatctcttgg gtcattataa aagtcattat
    28021 atattgtgta atctccaact tctatatttt cccttgttat tacattttta agatatacag
    28081 tttgataatc attacttctt ggatatacct tatttgaact tggaatagtc atatttaaat
    28141 ctctccttta atatatatta tgtttttgac tattccacta ctacaataca tctcttcaca
    28201 gaatcactcc ttgttaagaa tcttcataag ataatggcgt ccttttttag tgttaagtcg
    28261 gatattcttt cttagtccat tctttttagc gtataactga caaactgtca ttttcttacc
    28321 aatagtgtca atgctatcat caaggtcatt ttgtattgct ttttccttat cccttaatga
    28381 tatatcatca cgttttccct ttgggggttt atcagtaggt acaagtttcc aagagtaaac
    28441 aaattgtggt ttaccaaatg aatatacata cttatatgcg tatcttccat cttttctctg
    28501 gctctctcca gttcttaaaa ttctatcttt attatctcgt cttttttcag ttgacatgat
    28561 aagaagctcc tctcaataac cgaattgagc ttgatacgtc atatgaatat tataacatat
    28621 aaggctcaat ttcattagat aaagtcaagt gtatcaacga ttttctcaaa ttgttttctc
    28681 tttatttgaa tgcgattgct attcataatg acccagccag aatcaaggtt ttcatcagca
    28741 agtttacgta attttttctc tccaatacga aagtattttg acgcttcttc aatcgtcaag
    28801 gtatattttt cccaaatagg tacatcagta ttgttcatag aatgtatcac tcctttctat
    28861 gttcgtagtt cagaagtaga tagatggctt tggtaagctc cattggtatt ttaaccaatc
    28921 ccattcttat gggcagaacc gtgtcataca ggtgtatcat tatactgtgg tacaggttac
    28981 ggcaaaacaa ccgttccaaa ggttattcac aaatcactat atagtagctc tcttgattaa
    29041 ggtcatggcg tatagtattt gttggctatc tgtatcacaa acgtatctat ctactttatt
    29101 cagttgtcaa agaacagtcg gcattgattt gtctataaaa aatcacaata gcttatgggc
    29161 ttttatagac aaataattag tgattctcca tgtaccaaat agcttgatac atggagagag
    29221 ggcgagatta agacaaatta aatctcaaaa tagcagtgat tagttttgtt cctagcattc
    29281 gctttgtttc ttcttctaca tgaatatagg gatttccgta ttcatcaaat aaagttttct
    29341 gtgaaagacg aatgatatag tgttcaaaat gtttaagtat tccgtttatt gcatttacat
    29401 cgccatgtac agcaagtaaa ataattgtaa aaggtaatac ttctttagta ggtttcattt
    29461 caatgttcct ccatgagttc tttcaactct tttagtgcat ttgttttgtg ataatgtatg
    29521 gtattttctg ctaaatccat caatgttgct atgtcagcat ttgtcatgtt gagaaagaat
    29581 gaaagtagaa ttatatcttg ttttcttttt gtaagttttc cgattgcttg tgccattaat
    29641 acatcttcaa ttcgtatgtt gtagtcgtaa gaaaccatac agatgtagtt agaatcataa
    29701 tcatctaaaa tactcaattt acttaattct gcaagtgaca aagattcgag agataccaaa
    29761 taatcatttc tgcgtttatt ttcgtcataa atatctctag catagttacg caaaactgtt
    29821 ttacagaaac tgtcgaattg atgttcaatt gtcttttcat caaccataag atttcaccct
    29881 ctttccatcg caaggagtta aataaccttg cttactccta tcacggtggg agggcgttaa
    29941 atcttcgata aatttcaaaa aaaagagaaa aaaatacaca ctctgcctat agggcaaaaa
    30001 tgtgtattct ttaaaacgta tttaatttat attggttgta agccaccacc atattgatgt
    30061 atggaaatat gcattggcta gcttttcata aaaatacaaa gatgcataag aaattaatag
    30121 aggggaaaaa cttattctgt tattaaaaag taggttaatt ctaataaatg ctattgcggt
    30181 cgaattaaac tatatacatg gcaatcaatc atgtttctat tctttattat gaattgtgac
    30241 agtattcttc aatcttaaaa ccacattttt ccaatacttt acttgaccct ctattgtagg
    30301 aatatacatt agcatgaatt ttgttaaggt tgtatttttc aaaggcaatt ttgcatattt
    30361 cttttactgc atttgttgct atccctttgc cccaatagtt cctagcaagc cagtaaccta
    30421 attcagcatt tttattaata gaggtatctt cttcaaatgt taggctgata cttccaatag
    30481 ccctttcttg ataaaaaata gcatagctaa gttgtttaac atctggagtt gccaaacaaa
    30541 aactaacaaa atctctagcg ttttgctccc tataagggtg ggggaagttg tcacgaagat
    30601 tctttgcaat ttctttatca ttcgcaaact caactaaatc ggtaatataa gcataattcc
    30661 actctataag ttccattttt cttctccttt tatgaaacag ctacaagaaa tctttctaag
    30721 ccaataccac ttatcaaaca gcgttctttt ttatttccaa gcatttgata agtccagtca
    30781 acaaatccac cgtcaactat ttcaacggtt tcatttcctt gtttgaccga taatttgaaa
    30841 ttgatacctt tataataatt attatcaaca tcatcattat gaattgataa ctctatatta
    30901 ggaaaaataa gtttgatagt ttcaaccatt ctgtcgaaaa atccgtcatt atctttgtat
    30961 ccgtttcttt tgcgtagaat aatagagaaa cgaacatttt ctatttcact taatatatct
    31021 ttataatagt ttaagtgctt ttctaacaac attttttcac aagtgtaaga ccctgtatct
    31081 ataccagatg aaaccataca atataagcca aaatgtgaat ataaaccttt acctacaaaa
    31141 ttttgtgctc ttattaccct agcagtagta gccatgtgga taggtatggt attattttct
    31201 tcttttcttt ttaatttatc agcaataatt attgccaaca tatttgaggg gtctgcaagt
    31261 gtttctgtcc ctcgtagagc acttactaca ttatattgat ctacggagcc aaaaacgcta
    31321 cagctaccta atggagcaga gggagaaagc ataatcgtct tgatatccat attgaatgct
    31381 tttctcaata attttgactc caaagcatga atttcttctg gatctatacc gctagggata
    31441 gtaaatctat ttagttggta tgactttaga atatcagttg cagttaaagt atttgcttgt
    31501 ctatcaaaca cttctaatag aagtgagttc aaatctgatt ttgatagagc tgataactta
    31561 tcaactatat tcttatcccc aattttattt gtaattctac ttaaaatatc actcatagtt
    31621 atcctccata ctgttacttt caaaataatt atagaatggt tacaacaact aatctaggtc
    31681 atttgaccaa aaatgaaaaa acactgaata tttactattc aatatttttt tactttgggt
    31741 ttatttgatt aaatcttgaa aatactgtaa tgcaaccctt tcagcttcaa cctttcggac
    31801 aataggactt tgtgataatt cctctcttaa ctcaagatac aggttgatag tagcctgcaa
    31861 tgcattaaca cagcttttat attcatggtt agcaaccgtc ttttctaatg cttcaatata
    31921 ttggggtgcg tccaattcaa tttttctaac tccacgaggt aatttaccta agagaagctg
    31981 tattaatggg gcaagtactg attgtcttaa aaaagataaa aaatcaattg tttcaaatag
    32041 ttctctacgt ccaatcttag tgcaagcgta atgaacccaa atccaaaatc tatcttcaat
    32101 ccactgtaag tctggagttg ggaagtatgc ttctttttta gtataacacc tctcactttc
    32161 ttttattagc tatcaatcca acataattat gcataggagt attatataat gaaaaaataa
    32221 aaaaaaatag gtcacttgac ccgaaataaa aaagcattga ataattatta ttcaatactt
    32281 ttttgaaatt atacttatgt tgtaggaaga ttctttaata cctctcgctg attaattaca
    32341 ctaaatcttt tgttttcata agcaattaga tgttcttgta cacattcatt tatagcacga
    32401 ttaatgcttc taattggagc gtttacttcg ctagcaagct gttttttggt aagcagattt
    32461 aattcacttc tataatagtg taaggatata cacctcagaa gtcgttcttt aacacttaaa
    32521 gatgataatt cttcaattaa ttcagcattt acaactaatt tactagatat ttctcgaatc
    32581 agaaattttg tagcttcaaa atctcccctt aaccagttta aaaaatcatc tctatgaagt
    32641 ttatatacat tacaatctgt gaaagcgaca atttcaacgg gttttttccc atcattaaat
    32701 tgttccattt ctccaaaaaa actaccactt ctataaagat gaatagttga gatgtttcct
    32761 ttcacattta agatgaatgc ttctgcaata ccgtcaatca taagaattac atattcattt
    32821 tcttgctcag caaaaagaat agtctctttc tttttatacg tttttttaac aagcttcttt
    32881 ttaatatctt cattcataaa atcaattaaa tgcatattca tccctcctta ccaaatcttt
    32941 gattaaatta tatcatcttt caattagtta ggtaagatag taaaaatata tttacataga
    33001 aactattcca ttattatttt ccagttgtca tttttctgca aagtaagctc aaactgagaa
    33061 agctgttgac aatagaacta gtaggaatat atgagcgaac catttcagta ttcaactgtt
    33121 gtaggttttc agtcagataa ttcttcaaac gttcaattcg tttgtcctgt gaatcttgcg
    33181 atgctctaac cagtttcata gatagcgttt taccttgtgc cacctgcaaa aaagaccatg
    33241 cttcgtcaag gtcaactatc ttgaagctag agcggtcagt atgaataaag tctaatgcaa
    33301 aggtactaat aacaatcaac atagcaacac taagaagttc tattgttgta tattcttcaa
    33361 agctagtgtt ggcatctggc aatacgaggt cagcaacttg aataatattc agctgtttct
    33421 ccaagctgat agactgcttc acatttccgt caccaaacag tagatgtgca aaatcatagt
    33481 ctacaaaact ttcgatatgg tcggctatgc tgttactgat agaagtatct tcttttcgta
    33541 attcatcaat gacaagtaat aaccctcgct gttcactttg ggttacattg cggattgctt
    33601 ttctaagcac tgggaactta tcactgtcac gactggagat accagcaagg aatgttagga
    33661 tatcaatcgc taaactttca gaatcatttt tacggctcaa aatgacgtaa gggtcaagca
    33721 atcctttgtt ttcatcatta ctggttaaat tgacaatgtt tatctcatgg gctatttctg
    33781 gtagcgtttc tttccatttg ccgcgttctg ctttagggtc aactatgacc gcctgtccgc
    33841 cgaatagtac cgcatagtaa acaagcatat tgttactgaa taatttacca ccacccaatg
    33901 aaccgataaa cgcagacgct aacacattgg taatagaacc ctttacccat tgactagcaa
    33961 gggcaggttt tagatagaca ttctttccag tgtccagatt gtagccaaga tagatatcct
    34021 catgttcgcc aagggtttgt gtcgctccaa aaccaagtcc agccaaaaaa tccgaagtga
    34081 catattgaat ataatcattg atgtaacgtt tgctgacagg aataaattcg ccatgcaatc
    34141 ccaacatatc cccaaaggga cgcacgagct tgagtgataa gtcgtcgtaa aagtctttga
    34201 cttcatcaca acgccttttt agctcgtcaa gatcctttgt agatacacgg acaacatagc
    34261 taagtttata catagattct ttacagttaa aagtctgttt ttaaaaaaat gtataaatta
    34321 taaatcaaaa tatagatact atcaatgacc cactaggtgc aaaaagcatt gatatggtta
    34381 aattatcaga cgctaaaagc tgggctatcc gaatgagtga agatgggtgt gcttataaat
    34441 ccattgacaa ttataagcgc tcactgaaag cgtcgttttt catggcaatt caagacgact
    34501 gtattagaaa gaatccattt aattttcagt taagtgatgt tttggaagat acaacagaac
    34561 caaaaatcgc tctaacacca gaacaggaaa tgggcttatt atcctttatg gagagcgata
    34621 agacttattg taaatattat gatgatgttg ttatcctctt agaaacagga ctacgcattt
    34681 ctgaattatg cggtttgact ttagaattgg atatgaaaaa taaagccatt atggtagacc
    34741 atcaattgtt gagtgatact aagattggct attatgtaga agttccaaag accacacagg
    34801 gtaagcgaga aattccaatg actgaaagag cttatcaatc atttgaacgt atcgtggaac
    34861 ggcgtaagaa cgctaaagca gaaccaatca ttgttgatgg ttaccagaac ttcctatttc
    34921 ttaaacaaga tggattacca aaacaagcaa ctcattatca aagcatgtta agagcgttag
    34981 tcaagaagta taataagacc catgaggaca agctaccaaa gattacgcca cataccttta
    35041 ggcatacact ctgtacaaat atggctaaca aaggaatgag tcctaatata ttgcaatata
    35101 ttatggggca taaaaacatt actatgacgc ttggctatta tgcacatggt tcatttagtt
    35161 cttcgagagc tgaaatggaa cggttataat cctagtagta tgactagagt ttactactta
    35221 tttactactt ttgatggcat tcttatacgg ttaaatgcca acttatgcaa agtatcttcc
    35281 aaaaagaaaa tgccgatact ccttgtagat acaggatata tcgacattta ccaacttatg
    35341 aaaagataat caaatttaat ataagttttt caaataaaaa gataccaaat tctttttcga
    35401 gaatctatat aacattactt aagcttggtt ggggtataaa caattgagta gctacttttg
    35461 tatggtgttc aactttagtc aaaactctta agtaatgcaa atgatttaga ttcattaata
    35521 ttcaatctct tcataagtag tgaaattcga gttatttctg cataattata ctatgattta
    35581 tagattaatt ctattagcat ccagaataat attgtttata tgagtaaaat ttaaagaata
    35641 ttgtgaaaat tataggatgt taaaataaat ttaggtaaaa aagaagtgtt tgtatattat
    35701 agagtacctt ttctaaaata tgtgggattg ttttaagaat tagaataaaa attattttta
    35761 aattagtatt tttataatgt atagtatttt taatgtataa ttaaattgtg cagaaaatag
    35821 aatttaaagt cctatagaat ttctgattat ggaggagaat atgaaaagaa aagttcaagt
    35881 aaaaaatatt actattggag aaggtagacc taaaatttgt gtaccaatta ttgggaaaaa
    35941 taaaaaagat attataaaag aggctaaaga gttaaaagat gcatgtttgg atattataga
    36001 gtggcgagtt gatttttttg agaatgtaga aaatattaaa gaagttaagg aagttctcta
    36061 tgaattaaga agttatatac atgatatccc tttattattc acatttagaa gtgtagtaga
    36121 agggggagaa aaattaatat caagagatta ttatactact ttgaataaag aaatttctaa
    36181 tacaggttta gtagatttaa tagatgtaga gttatttatg ggagatgagg tcatagatga
    36241 agtagttaat tttgctcata aaaaagaagt gaaagtaatt atatctaatc atgattttaa
    36301 taaaactcca aaaaaagaag agattgtatc tcgtttatgt agaatgcagg aattgggcgc
    36361 agatttaccc aaaatagctg ttatgccgca aaatgaaaaa gatgtgttag tgctacttga
    36421 agctacaaat gaaatgttta aaatttatgc agatagacca ataataacaa tgtcaatgtc
    36481 aggaatgggt gttataagta gattgtgtgg tgaaatattt ggttctgcat tgacttttgg
    36541 agctgcaaaa agtgtttcag caccagggca aatatcattt aaagagttaa attcagtact
    36601 taatctatta cataagagta ttaattaaat taattatata gaaatattag acggtatttt
    36661 tgaagatata aattaaatat aaaaaacttt tcagatagta aaatttaaat tgggcaatta
    36721 tatctgaaaa gcaactattt agtgtgtatt ttgaaagtga tatagaaaat cttataaatc
    36781 aactatggca tatttaaaat atgccattaa aacctactag acattagatt atagatggta
    36841 tactagcatt tctattattt atagatagta agttttcata ataactgttt tatctaaagt
    36901 agaagatata tttgtattat gtatatttgt cattattttt ttgtaattat gtatattaat
    36961 ggttatatat gtaatataat attatcactc tattttttgt atattgtaca ttacaacatt
    37021 tatatctatc atcatcaatt acagtagaat gtatgggata cttattttca cttaaccaat
    37081 atttttgcat attctttgtc caagactttg gaaacttcaa tactttcttg tttattataa
    37141 catcctcatc ttcaaaaata ttaacttctc tttctatttt tatttttctg ttgtatatct
    37201 tattgataga ttctttgtcg agttttatgt ctctatacat atcagggcaa tagcaacaaa
    37261 cataatttct tttttttcga cgtttaaatt tcacaacttt ctctatgcta atttctaatt
    37321 tttttgtacc atcttttata aatttaatat cttctatgtt ctcgcttgaa aaaatttctg
    37381 tcaatcttaa agtatctaca gtttctctaa ttatttgctt tttataagaa gagaatccat
    37441 atccaaaaga aaggtttaat ttattaggga tgtagccatt tttatattta aacatcttaa
    37501 ttttttccaa ttcagcatta tctttaaatt tcaacttttc atacctaaaa gttactttgc
    37561 taaaaagagt atattctaca tcaatatatt cttttgcaat cttaaattta tcgctacctt
    37621 caatcacaat catagcctat ctccaatcgt tttatattaa aataaggcca tagaacatgg
    37681 tctaatagta ctcattagca ctataagaca atgttaacac aaaaagacaa aaaaaggtta
    37741 tttatttcaa ataacctttt tttttatata aaatataaag aattatattt tattcttttt
    37801 tatgatgtct ataatctgtg atatcagatt tagttctctt gaatttaagt cttttaactc
    37861 ttcatttata tcattttcta aatatgtttt tccagtggaa gtaatatctt ttataagaac
    37921 atctgcagaa atatttaata tatttacaaa ttttatgaat gttttaagac ttggattctt
    37981 tttaccactt tcgatttgag ttatatacca aggcgatact ccaaccatat ttgcaaattc
    38041 ttttgaagtt aaatttgctt ttttccgttc ttctttaagt cttttaccta tataattcat
    38101 tattgttact atttccctca cttatatttc tttgtattta atgatgcact ttattaactc
    38161 tagcattgca atttgttctt tttcagttaa tttattaatc atttcataac attctaaagg
    38221 tacagagtta tcaacgcctt ctgttgtaat aatatttgca aataacaatt caagtggtat
    38281 gtctaaagca gtagcaattt tcattataat attgatagat gtatttgtct cagctctttc
    38341 aatctgacca atatatgttg gatgtaaacc tgccttttct gctagaaact cttgactata
    38401 tcccaatttt gttctataga cttttattct atctcctatt atttttccta tatttgccaa
    38461 ttattatccc tccactttag attatattca tagtttaagt tgttttatat agactattta
    38521 tactttttta gtctaaatat agactatata tgtttttata ctgaaataag tgctatttat
    38581 ttttgtatag tctgtatcta caataaacaa atatggataa atcatatttt taattagaga
    38641 aatattttca taatttcata accatactac aataataaaa cgaattaata atatgttaat
    38701 tatagcat
//
LOCUS       DAEPID010000036        37013 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.036, whole genome shotgun sequence.
ACCESSION   DAEPID010000036 DAEPID010000000
VERSION     DAEPID010000036.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 37013)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 37013)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..37013
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.036"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            complement(282..1532)
                     /locus_tag="KR257_001999"
     CDS             complement(282..1532)
                     /locus_tag="KR257_001999"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418703.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1015 domain-containing protein"
                     /protein_id="HBH0030701.1"
                     /translation="MATIKPFKAIRPNKYIVDKVAALPYDVMNSKEARRIAEGNPYSF
                     LHIDKSEIDLDENIDLYDEKVYLKARENLDEFRKQEILVKDDKECIYIYKQIMDGRAQ
                     VGIVACISVDESLNGTIKKHEYTRPEKEIDRTKHIKYCDANTGTILVTYKHQRVIDDI
                     INDFMDNNEPLYDFITDDKIEHTVWKIDNDDIIDNLVDKFEKLDYLYIADGHHRTASA
                     ENVAKEMRAKNPNYTGKEEFNYFIAMIAPDENLMVLDYNRVIKDLNGLSEEEFINKIK
                     ENFELEEIEGKEKYKPDKKGTFGMYLGDKWYKMKANKNLLEIEDPVDSLDISILQDYV
                     IDAILGIDNPRVDKRIDFIGGIRGLEELEKRVNEDMKVAFAMYPTSIEDLIRVADANK
                     IMPAKSTWFEPKVRCGLFLHEINE"
     gene            complement(1565..2506)
                     /locus_tag="KR257_002000"
     CDS             complement(1565..2506)
                     /locus_tag="KR257_002000"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437082.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="D-3-phosphoglycerate dehydrogenase"
                     /protein_id="HBH0030702.1"
                     /translation="MYNILVTDGIEKEAARKLRELDFNVIEQFYEKDVLGDKLKDVDV
                     LVVRSATKVTKDVIDKALEGKKLKLIVRGGVGLDNIDVKYAQANGIKVMNTPNASSIS
                     VAELTIGQLFVLARFINTANVTMRDGKWEKKKYKGTEINGKTLGLIGFGRIAKEVAKR
                     AELLGMNVIYTDIMGEAQGFNNYKFCDMEEVLENADFLSLHIPFDKNKGAVITEKEIN
                     KMKKGAYLINCARGGLVDEKDLLKALDEGKLSAAAIDVYEQEPTLNLDLVNHPRVSPT
                     PHIGASTVEAQERIGDEIVNVIQDFFLDFNNLIGVAL"
     gene            complement(2746..3822)
                     /locus_tag="KR257_002001"
     CDS             complement(2746..3822)
                     /locus_tag="KR257_002001"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004453520.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alanine--glyoxylate aminotransferase family
                     protein"
                     /protein_id="HBH0030703.1"
                     /translation="MSKKLFIPGPIDVKEEVLQKMATPMIGHRGKDASMLQKSISEKM
                     QKLFYTNNTILLSTSSGTGLMEGSIRSCTSKKAAVFSCGSFGDRWYKMAVANNVPADI
                     FKVELGEATTPEMVDKVLSTGEYDLITVTHNETSTGIRNPIEEIGEVVKKYEDVIYCV
                     DTVSSAGGIKVEVDKIGIDICITSVQKALGLPPGMSICTFSQKAIDRAKQVPFRGVYL
                     DLLAMYEYLIKKNYQYPSTPSLSHMFALDFQLDNILDEGLDNRFNRHEDMANLVRNWA
                     KKHFQIFTNENHLSNTLTVIENTQGISVSNLNSKLQERGFQIANGYGDLKEKTFRISH
                     MGDYTVEDVQELLDNIDDILGFNK"
     gene            complement(4195..4710)
                     /locus_tag="KR257_002002"
     CDS             complement(4195..4710)
                     /locus_tag="KR257_002002"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437086.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PaaI family thioesterase"
                     /protein_id="HBH0030704.1"
                     /translation="MDFLAKYKVLKKQNSSKSCLVCGTQNELGLKADFYELENGELVS
                     ICNTKDWHQSYPGRVHGGMSAAILDETIGRAVSINDDQIWGVTVSLELKYKKPVPTDA
                     TIKVVGRITKENRKLFEGTGEIILPNGDIAVTATGKYMKMPIGQIAEGDFSNEEWFFE
                     ESKEKVEYIEL"
     gene            complement(5073..6143)
                     /gene="leuB"
                     /locus_tag="KR257_002003"
     CDS             complement(5073..6143)
                     /gene="leuB"
                     /locus_tag="KR257_002003"
                     /EC_number="1.1.1.85"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895944.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="3-isopropylmalate dehydrogenase"
                     /protein_id="HBH0030705.1"
                     /translation="MNCNIAVIKGDGVGPEIIDEGIKVLNKICCKFNHRFDCEYVLAG
                     GCAIDETGEPLPNKTVETCRKNEAVLLGSVGGPKWDKCKGDKRPESGLLKLRESLGLF
                     ANLRPATMYESIKEASPLRTDIVEKGIDFVVVRELTGGIYFGERGRKIIDGIENAYDV
                     EIYNENEIRRIGKRAFEIARNRNKKLISVDKANVLESSRLWRSIMEDLAKEFEDVELS
                     HMYVDNAAMQVVKDPSQFDVIVTNNIFGDIISDEASMITGSIGMLPSASLREDSFGMY
                     EPIHGSAPDIAGKDIVNPIATILSVSMMLRHSFNLEEEAKCIEDAVQSVLNKGYRTID
                     IYNGVGNVVGTREMGELIVNEI"
     gene            complement(6150..6641)
                     /gene="leuD"
                     /locus_tag="KR257_002004"
     CDS             complement(6150..6641)
                     /gene="leuD"
                     /locus_tag="KR257_002004"
                     /EC_number="4.2.1.33"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004453523.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="3-isopropylmalate dehydratase small subunit"
                     /protein_id="HBH0030706.1"
                     /translation="MIANGSVFKFGDNIDTDVIIPARYLNIADYKELATHCMEDIDDK
                     FISKVKKGDIIVATKNFGCGSSREHAPIVIKESGVSCVIASTFARIFFRNSINIGLPI
                     LECEEAANNIDEGDNIEVDFSTGVIKNITKGKEYKAEPFPEFMQNIILNEGLINSIKA
                     NRG"
     gene            complement(6656..7933)
                     /gene="leuC"
                     /locus_tag="KR257_002005"
     CDS             complement(6656..7933)
                     /gene="leuC"
                     /locus_tag="KR257_002005"
                     /EC_number="4.2.1.33"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418697.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="3-isopropylmalate dehydratase large subunit"
                     /protein_id="HBH0030707.1"
                     /translation="MGMTMTQKILAKHAKLNEVKKGQLIEADLDVVLGNDITSPVAIR
                     EFEKLGIEDVYDKTKVVMVLDHFTPNKDIKSAEQCKFTRSFAKSKGVVNFFDVGDMGI
                     EHVLLPEKGIVTAGDVIIGADSHTCTYGALGAFSTGVGSTDMGAGMATGKCWFKVPGA
                     IKFVLKNKPNKWISGKDIILHIIGEIGVDGALYKSMEFCGDGVEYLSMDDRFTICNMA
                     IEAGAKNGIFPVDDKTMEYINSHKCSTMTKDVNIYEADEDAVYDEVYEIDLAELKETV
                     AFPHLPENTRTVDEIDKDIKIDQVVIGSCTNGRISDLEVVAEIMKGKKVADGVRVMIF
                     PGTQKVYLEAIEKGYITTFIEAGAAVSTPTCGPCLGGHMGILAAGEKSISTTNRNFVG
                     RMGHVDSEVYLASPAVAAASAITGKISKPSEII"
     gene            complement(7890..9632)
                     /gene="leuA"
                     /locus_tag="KR257_002006"
     CDS             complement(7890..9632)
                     /gene="leuA"
                     /locus_tag="KR257_002006"
                     /EC_number="2.3.3.13"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892859.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="2-isopropylmalate synthase"
                     /protein_id="HBH0030708.1"
                     /translation="MKCGKYKKYDKMQIVNRKWPDNEIFKAPIWCSVDLRDGNQSLPT
                     PMSVNEKVRMFKMLIDTGFKEIEVGFPSASNTEYTFLRKLIDENMIPDDVTIQVLTQS
                     RAHLIEKTFESIRGCKKAIIHLYNSTSVLQRDVVFNMSKQEIIDIAVEGAKLFNEEVK
                     KYPETEFTFEYSPESFTGTEMDYALEICEAVIDVWKPTPQKKVIINLPSTVEMATPNV
                     YADQIEWFCKNISCRDSIILSLHTHNDRGTCTAASELGLLAGADRLEGTLFGNGERTG
                     NMDIVNVGLNLYTQGIDPELDFSNIDKIIGIYEDCTKLMVHDRHPYAGNLVHCAFSGS
                     HQDAIRKGMIAMKNRDNDYWEVPYLPIDPHDIGREYKEIIRINSQSGKGGAVYIMETD
                     YGFMIPKNMHSDFGNVVKMESDRIGEELSSEAIFNLFKKEYIEVESPYKVKKYKIKSM
                     DELNYENDDSNDTNMIEMTARISYMGNEQRIVGIGNGPVDSFNNALKQCGMKDYKFRY
                     YWEHALEEGSHSRGVAYVGIEHNNEVYFGVSISENINTAAINALMNAINKSYIEEEIK
                     NGDDYDAENISQTC"
     misc_binding    complement(9756..10002)
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00230"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="T-box leader; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /bound_moiety="tRNA"
                     /db_xref="RFAM:RF00230"
     gene            complement(10150..10596)
                     /locus_tag="KR257_002007"
     CDS             complement(10150..10596)
                     /locus_tag="KR257_002007"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861059.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0030709.1"
                     /translation="MSKNKFIYMNYYDNGYFKKGMTIYMVLALIILATIFIYSTTILY
                     ILCIITAVFLFKQGRDFSNKYEGKVYITLDNHSILINNQCIFSIKSKQSQKFNYKIIE
                     KIEVVKNILNIYTNESNYKIRLRALSLEDEKKLLNIIDEKMKKFKA"
     gene            complement(10617..11336)
                     /locus_tag="KR257_002008"
     CDS             complement(10617..11336)
                     /locus_tag="KR257_002008"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895939.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphatase"
                     /protein_id="HBH0030710.1"
                     /translation="MKKSIMDVHCHTLISGHAHSTFKENVEEASKKNIKYLGISDHGP
                     NMPGGPHPFYFYNLHLLPREVQGVKILRGIEGNIMDYNGNLDVQEDMLQHLDYIIASL
                     HRPCIASGTKEENTNAILKVMDKPKVKIIGHPDDSRYPLDYEPIVKKAKDKNILLEIN
                     NSSLSSNSHRTGTWENVSHMLTLCKTYGARVILGTDSHICYSIGEFENAEKVLEAVDF
                     PDELVINYHEDEIIEFFDINF"
     gene            complement(11454..12728)
                     /locus_tag="KR257_002009"
     CDS             complement(11454..12728)
                     /locus_tag="KR257_002009"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418693.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="S1 RNA-binding domain-containing protein"
                     /protein_id="HBH0030711.1"
                     /translation="MFIMENDLTMQELLDQQEQVFSKVKVGELTTGKITAVRNDEVQL
                     GLDYGFDGIIPISELNIEKNQYIEDIYHIGDEITAVITKVSQKDGTITLSKLQLDKRN
                     DFAELQKAYDEHRIITVNVEKNIDKGVFANYNTYTFFIPISQLDTKFITDTSKFVGLN
                     LEVYIKELDVRKNRLVASHRDVLQERINKEREERRAQIKAEKEAERARIKQEREEEKA
                     RIKAAKEDLFNSLEVGQKRDGKVTKIMPYGAFVDIGGIEGLAHINNLAWTRVESVEDV
                     VSEGQEVEVYVLDVNKETKKIALALKDINNDPWDLIAKEVQIDDVVNAKVLRIIEKGA
                     FVQIKEGVDAYLPISELSDTRVAKVTNVVNIGDEVKVKILDFKPKTKRMLVSIKEATR
                     EPEEDITEYLEVEESLGSIGELFKDKFKDLEV"
     gene            complement(12928..14295)
                     /locus_tag="KR257_002010"
     CDS             complement(12928..14295)
                     /locus_tag="KR257_002010"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437109.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MATE family efflux transporter"
                     /protein_id="HBH0030712.1"
                     /translation="MENSNTNLGSESVGKLLFKLATPAIIAQIVNVLYNIVDRIFIGR
                     MENGEVAMAGVGVAFPIIIIITACSYLIGMGGGPLAAIKMGEQNNDEAEKIMSNSFSV
                     LVILAILLTIGFKIGKEPLLWMFGASESTIGYSMDYLNIYLIGTVFVQISMGMNTFIN
                     TQGFATTGMMTVAIGALINIILDPIFIFGFNMGVKGAALATIIAQGVSAIWVLMFLFG
                     KKSILKIKKKYMIPKASIILPVLGLGISPFIMQSTESLVLIALNSKLQMYGGDLAVGS
                     MAIMSSIMQILMLPNMGVTQGAQPIISYNYGSGQLDRVKKTFKLCLLSCFTYSTILWL
                     LLMIFPAFFVSIFNKNPQLLSMTSWSIKIYFAGAFMFGIQIACQQTFLALGKATISLV
                     LALLRKIVLLIPLIFILPTFFNEKLFAVILAEPVADITAATITAISFFIFYKCFLSKP
                     KAIKE"
     gene            complement(14545..15009)
                     /locus_tag="KR257_002011"
     CDS             complement(14545..15009)
                     /locus_tag="KR257_002011"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437111.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="small multi-drug export protein"
                     /protein_id="HBH0030713.1"
                     /translation="MSLRIGGNSLGYLHILILSMVPVTELRGAIPIGIAMGLNPIWVY
                     VFSVIGSTLVSIPLILTFRHVLQFLRGKKLFKGIADVIDRKINSRMKKLKSVSIIGII
                     LFVGIPLPTTGTWTASAIASILKMRIKDAFMGVFLGNLLSGVIVSALSLHII"
     gene            complement(15014..15643)
                     /locus_tag="KR257_002012"
     CDS             complement(15014..15643)
                     /locus_tag="KR257_002012"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895936.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HAD-IB family hydrolase"
                     /protein_id="HBH0030714.1"
                     /translation="MKKSVLLLDVDYTVINTDSMIDFFIYSLKNKTFKTIIKLPYIIF
                     ILFMYLIRIIPLKKAKEAIFYPIVDFSEEDLKKFFDDCIMKKINESMKKVIYKNKEED
                     NVIIMITASPYAYMKYFKYYGLADEVIGTEFFYENSRYKNKFIGENCKGIEKVKRIKA
                     VLGKLGIEIDYENSYAYSDSKSDLPMLSLTKNAFLVSKKDGEVIEQINS"
     gene            complement(15677..16564)
                     /locus_tag="KR257_002013"
     CDS             complement(15677..16564)
                     /locus_tag="KR257_002013"
                     /EC_number="2.4.2.45"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861057.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="decaprenyl-phosphate phosphoribosyltransferase"
                     /protein_id="HBH0030715.1"
                     /translation="MKQTNTSIRLLTKISDYIKLMRIKQYIKNFFVFSAIIFSNNILN
                     INLFLNTFIAFVCFCLMSSSVYALNDAIDMDKDKKHPKKCNRPVASGRISKKSANILF
                     VVLALISVCLSTVVSFNLSIILSLYLINNILYSLKLKNIILLDVFSISLGFILRVYAG
                     CVAISVSLSNWIILCTFFLSLYLALGKRKKEIETLRDDAVEHRKILEDYDIENLNQMM
                     IVILSSTIVCYALYSTSNPEKPHMIFTTIFVVYGVLRYNYIINTTNENNPTDIVLKDN
                     ALKINVILWIITCLIILIF"
     gene            complement(16593..17831)
                     /locus_tag="KR257_002014"
     CDS             complement(16593..17831)
                     /locus_tag="KR257_002014"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418682.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0030716.1"
                     /translation="MDGDILMSKILKYKNEMFLFILVVITYLIITKIFFSKTTIFYDL
                     NNTYDVLLDTDTGVLFNLNVFAISQDNSKHILFSAIISIFAYPIYLFCTSIANPGTTD
                     FNSAYGFGLICLQIITSAMSITLVFNHIKKIKMQRLTLILLTMIMIFSFPQLFMTLNV
                     ERFIYSQFSLIFFIVIANKMKGKNSYLVELAAIPLFGITISNIYLYFFNMIFEFKLKI
                     GKMLKHLITFILMAYICVVSTKSYESFMNLGNVIQYDTKFISGEPILEKIAMIIERLL
                     YSVFYFPGASIKKGLFLQNGEVATIPVILTLLALCFCVLSVIENSEKRVPKLCMGIII
                     FNLTLHGIVGYNLVNSSIMAINFSFAVIILLAYFTKALRKNEKNMYNIFLSLLLVTIV
                     ISNVNGFIEILNIGIKSYPV"
     gene            complement(18215..19357)
                     /locus_tag="KR257_002015"
     CDS             complement(18215..19357)
                     /locus_tag="KR257_002015"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437122.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aldo/keto reductase"
                     /protein_id="HBH0030717.1"
                     /translation="MRYVEYGKTGKMVSVVGYGGLRFDLEKSNQENADLVKYAYEKGI
                     NYFDTAPGYCDDRSEDIFGLAFRQMIKEGKTDFYVSTKEKPKACDTSEKAIEAVKKSI
                     ERLGVSKINFYHVWNIRKMEHYELAMRPGGQYEGLLKCKEEGLIDHIVFSSHQPGDEV
                     IDILSENKFEGVTMGINILNFPYRLKGAKYAVDNGYGVVAMNPLSGGTIPKYNKELSF
                     LSKDGESTIESALRFNIGISQISISLIGFNKKQDIDDACKIADENRIYSDEDIHDIET
                     RLNKNMNEICTGCGYCKVCPKGINTPAYMLFYNEKQMFKKSDEEMTKLVYGLGHWNYT
                     MNSKAKAKECISCGKCEVECTQHLPIIDRLKEIKKWEEDGANSVKV"
     gene            complement(19498..20364)
                     /locus_tag="KR257_002016"
     CDS             complement(19498..20364)
                     /locus_tag="KR257_002016"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004453540.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cation transporter"
                     /protein_id="HBH0030718.1"
                     /translation="MDNYKKVKQVLWIILFANFAVALLKIIIGNQIKSYSMTADGFHS
                     LSDGASNIVGLIGIFFASKPKDKNHPYGHKKFEIITSLFISGMLFVIAIKIILSAVLR
                     IANPVVPAITIESLIALIITLFINIFVCMYEYRIGTKLNSYVLISDSLHTRSDIFVSL
                     GVLVTLVGVKLGFPVIIESIVPIIISAFIIYSAYGIFRPSIGILVDRVAVDEDYIKEI
                     VFEFNEVRDVHNIRSRGSKSSIYIDMHVMVDPFISVEQSHDLTHKIEKQIQEEINENA
                     QVIVHIEPFYSF"
     gene            complement(20698..22245)
                     /locus_tag="KR257_002017"
     CDS             complement(20698..22245)
                     /locus_tag="KR257_002017"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895932.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease subunit"
                     /protein_id="HBH0030719.1"
                     /translation="MANFFNFILLQKDKIIELLIQHMSLTVTSILIAIIVGVPLGIII
                     SRISSLRKFVLGFVNLVQAVPSMALLGLLVPILGIGSKPAIFMVVVYSLLPIVKNTYI
                     GITSIDPVVLESAKGIGLTRNQTLFKIQFPLALPIIMGGVRISAVTAVGLMTLAAFIG
                     AGGLGYLVFSGVQTVNNNMILAGAIPSCIIALLVDYLFSKIEVAVTPKGLNPKAPKKN
                     YIALKVISVVLVVSMLFVVFSSSFSSKKDTITIGSKDYTEQLILGNVYAELVEKNTNL
                     KVKKNLNLGGSSVAFNAIKSGELDMYVDYTGTLLVNVMKHAPIKDADEAYNVVKDTME
                     KENQLTLLDPLGFNNTYTLAMMPETAEKYGINTISDLTKYGKEFTFSPTLEFENREDG
                     LVGLSRDYGLKFKDVKAMNGSLRYTALDNNESQVIDAFLTDGLIKKFNLKILEDDKNF
                     FVPYYAAPLVREDTLKKYPELEKVMNMLSGKINEETMRELNYQVDELGKSPEEVAHSF
                     LVKEGLV"
     gene            complement(22238..23374)
                     /locus_tag="KR257_002018"
     CDS             complement(22238..23374)
                     /locus_tag="KR257_002018"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437132.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBH0030720.1"
                     /translation="MIEIRNVTKKIGNNVILDDISLVVETGTLVVLIGSSGCGKTTTL
                     KLINKLIKPTSGEIYINGKPISQENEIELRRKIGYVIQNTGLFPHLTIKENIELIPRL
                     KKEKSVEEIEKRTLQLLEMVGLDSDEFLNKYPSELSGGQQQRIGVARAIATDAEIILM
                     DEPFSALDPITRTSLQEQLFSLQDELKKTIIFVTHDMDEALKIADKICIMKDGRIAQY
                     DTPENILRKPANDFVKDFIGEDRVWDNPEYIKARDIMIKNPIAVNSTRTVTQGIEIMR
                     TSKVDSLLIIDRAKTLKGIVTVKDMKDIDDKSILLADIMSSEPLHVNEGDNLVEILNV
                     MNRNSVGYIPVISDENKLVGLITRSSLLSVLSEQFLEMEVSVLG"
     gene            complement(23637..24734)
                     /gene="dinB"
                     /locus_tag="KR257_002019"
     CDS             complement(23637..24734)
                     /gene="dinB"
                     /locus_tag="KR257_002019"
                     /EC_number="2.7.7.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728707.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA polymerase IV"
                     /protein_id="HBH0030721.1"
                     /translation="MKHYRKIIHIDMDAFYASIEQRDNKKLKGRPVIVGGNPQSRGVV
                     ATCSYEARKFGIHSAMPSAVAYNRCPYAVFVRPRFDVYKSVSEQIRDIFYRYTDLVEP
                     LSLDEAYLDVTKNKKNIDSSIEIAKQIKKDIFREVGLTSSAGVSYNKFLAKIASDLRK
                     PNGLTVITEENAQDFLDKLPVNKFFGVGKVTSNTLKNLGIKTGYDLRCLNLFELENIF
                     KKRGYELYKFARGIDDRPVEPNRVRKSVGAETTLSHNLDIDEEETRNILDELCEEVCH
                     RLKNSEKFGKTLTLKIKYEDFTKITRSLSLEHYIDEYNDIRSGVDNLLRNVDVNGKQI
                     RLLGVTISNLSDKKETYKDITLFEYMDSIQM"
     gene            complement(25124..26629)
                     /locus_tag="KR257_002020"
     CDS             complement(25124..26629)
                     /locus_tag="KR257_002020"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003374392.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1846 domain-containing protein"
                     /protein_id="HBH0030722.1"
                     /translation="MKVGFDHKKYLEEQSKYILERVNNFDKLYLEFGGKLMGDLHAKR
                     VLPGFDENAKIKVLQHMKEKVEVVICVYAGDIERNKIRGDFGITYDMEVLRLIDDLRG
                     YELDVNSVVITRFEGQPATTVFINKLERRGIKVYKHYPTKGYPSDVETIVSDEGYGAN
                     EYIETTKPIVVVTAPGPNSGKLGTCLSQLYHENKRGNVVGYSKFETFPVWNVPVKHPL
                     NIAYEAATVDLKDVNMIDSFHLETYGEMSVNYNRDLELFPVLKKIIEKITGKESIFQS
                     PTDMGVNRVGFGIIDDEVIRKASIEEIIRRYFKTACEYKKGQVDKGAYDRMKMIMEEL
                     NLKPEDRNVVLPARNYSNKLKESADKNDTCPVVALELEDGTILTGKGSDLMNGTAAVV
                     LNAIKHLANISDDMHLISPVILEPIINLKTKTLASRNVSLSCQEVLTALSICAVTNPT
                     AQFAMEKLALLKGCQAHSTTILNRDDEQTFRKLGIDVTCDPEYPSQNLYYS"
     gene            complement(26891..27241)
                     /locus_tag="KR257_002021"
     CDS             complement(26891..27241)
                     /locus_tag="KR257_002021"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888730.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0030723.1"
                     /translation="MAIVDKIFNEIKLMVARLLLGKKYSEYEEKDLVYNTEEEVILIT
                     LKRLVFQGNVNEAEEILFDKAKSVNSENMQYIAIEFYTMLMEKTDEELEAMNFSKQEV
                     YQGIEDIRKVLNLE"
     gene            complement(27464..27655)
                     /locus_tag="KR257_002022"
     CDS             complement(27464..27655)
                     /locus_tag="KR257_002022"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418667.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0030724.1"
                     /translation="MLDRFFGEGGFGGCAWWIIILFFLFLAFQDCWAEMDLCAWIPFL
                     ILLLILCECGDVFDGGCGC"
     gene            complement(27773..28687)
                     /locus_tag="KR257_002023"
     CDS             complement(27773..28687)
                     /locus_tag="KR257_002023"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437142.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MBL fold metallo-hydrolase"
                     /protein_id="HBH0030725.1"
                     /translation="MRKIVLKDILFLVTTLSIIVILLLVTNITTNSKIKSTNESYLKS
                     DKNDVSQNNIQSSTKNTAFKTTILSTGKSDCILVEIGNKVIMIDTGEDKNGKQIVDRL
                     KEKGINTLDYLILTHLDKDHIGGVDSVLSSVKVKNIIQANYKKDSKQYDEYIDSLKKA
                     DIEPVLLKDNMNIVINSAEINIHPASKSKYESSNDYSIITNISYGAHKFLFAGDAEEE
                     RLSEFINGNTLKYDFVKMPHHGRYDKLTETFLESISPQYAVITCSEKKEPEEGVLKIL
                     ERLNIKTFLTSNGEVVINSDGKTLSVNQ"
     gene            complement(28821..30317)
                     /locus_tag="KR257_002024"
     CDS             complement(28821..30317)
                     /locus_tag="KR257_002024"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004453549.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="4Fe-4S dicluster domain-containing protein"
                     /protein_id="HBH0030726.1"
                     /translation="MFEFETQLKRLKHEVLTAVARLSIEENLTKENIEKIPYEIIKGE
                     KARYRCCVYKEREVVLERAQLALSLTPNSKYGDINPDSVSLDTDEQIIYIVEAACDRC
                     PINEFTVTELCRGCLAHRCKEACKFGAISYINGRAYINHDLCKACGMCKSSCQYDAIS
                     EVVRPCKSVCPTGALDFNRNTMKAMIHEDNCINCGACMSACPFGAISDKSLIAPVAKK
                     LAKKENMYAIVAPAITGQIDSNITYGQLKNAIKSLGFVDMIEASCGADAVTVHESNEL
                     IERIKSGDNYMTNSCCPGFFKYIEKMFPDEKDRISSTVSPMVATGRLVKKIDSDAKVV
                     FIGPCTAKKSEATEKSLKDSVDYVLTFEELMALFEAFNIDLSKCSNEDINDGSIFGRG
                     FGASGGLAKSVQNYIAEKGLSFDFEPIKVSGPRQIKKTMTMAKLGRLEGNFIEGMMCE
                     EGCINGAGKFLSGVKAKNTFDRKNGQSTKKSVLSNDKIKEFEDVNLER"
     gene            complement(30597..32087)
                     /locus_tag="KR257_002025"
     CDS             complement(30597..32087)
                     /locus_tag="KR257_002025"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888725.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="4Fe-4S dicluster domain-containing protein"
                     /protein_id="HBH0030727.1"
                     /translation="MFQFETQIHKLRHDVLTAIARLGKEDNLTREAMDNIQYEIIKGE
                     KPTYRCCVYKERAIISERVNVSMGLQPGQDKIDLDTMDIEEDEQIIYILEAACDSCPI
                     NEFTVTDICRGCLAHRCKEACKFGAITHVGGMAYINHELCKACGMCKKACQYDAISEV
                     VRPCKSVCPTNALGFDRENMKAMIHEDKCLNCGACMSACPFGAISDKSLIAPVARKLV
                     QKEKMYAVVAPAITGQVEANVTYGQIKNAIKSLGFVDVLEAACGADAVTVHESLEFAE
                     RMEKGEAFMTNSCCPGFVGYIEKTYPNHVGKISSTVSPMIASGRFIKSHEPDAKVVFI
                     GPCTAKKSEAAKKELKGAVDYVLTFEEIMALFEAFDIDLAKCSNEDIDDASIFGRGFG
                     AAGGLTKAIENYLAEKGIGVNFEPVKISGSREIKKTMTMANLGKLEGNFIEGMMCEGG
                     CINGSGKFLSGAKVKATFDRKNSQSTKKSVLANTKIKDFSNINLEK"
     gene            32554..32754
                     /locus_tag="KR257_002026"
     CDS             32554..32754
                     /locus_tag="KR257_002026"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000809131.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cold-shock protein"
                     /protein_id="HBH0030728.1"
                     /translation="MKNGIVKWFNNEKGFGFISVEGEDDVFVHFSAIQNDGYKTLEEG
                     EKVSFDITQGNRGPQAENVNRI"
     gene            complement(32920..33798)
                     /gene="speB"
                     /locus_tag="KR257_002027"
     CDS             complement(32920..33798)
                     /gene="speB"
                     /locus_tag="KR257_002027"
                     /EC_number="3.5.3.11"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888724.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="agmatinase"
                     /protein_id="HBH0030729.1"
                     /translation="MKNNFYHMNTFMSMNKNYEESNLIVFGVGFDGTTSNRPGARFAS
                     SSMRKEFYGLETYSPFLDLDLEDYNICDYGDLEISVGSTEQVLKEIYQETYKIVRDSK
                     VPFMIGGEHLVTLPAFKAVHEKYNDIYVIHFDAHTDLREEYNNSKNSHATVIKRIWDI
                     VGDNKIFQFGIRSGTKEEFKFATEEKHTYMEIGGIDTFENIVNMLNGKNIYLTIDLDV
                     LDASVFPGTGTPEPGGVNYREFQEIFKIIKNSNINIVGCDIVELSPDYDTTGVSTVIA
                     CKILRELCLIISDKIK"
     gene            complement(33788..34639)
                     /gene="speE"
                     /locus_tag="KR257_002028"
     CDS             complement(33788..34639)
                     /gene="speE"
                     /locus_tag="KR257_002028"
                     /EC_number="2.5.1.16"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437154.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="polyamine aminopropyltransferase"
                     /protein_id="HBH0030730.1"
                     /translation="MELWYTEEWTENVRFSIKVNKHLFEGKSQFQRIDVFDSDEFGKF
                     LTIDGLMMVTYKDEFIYHEMITHVPMATNLNIKKVLVIGGGDGGTVRELSRYPQIEKI
                     DMVEIDKMVVDVSKEYMDICSCKLDDKRVSLYFEDGVNFVKCAHDKSYDLIIVDSTDP
                     IGPGEGLFSTDFYKDCYRILTDDGILVNQSESPYFDFNAKEMKRANKKLKQIFPISEV
                     YQAHIPTYPSGHWLFGFASKKLNPVKNQDRNGWEKLSLKTKYYNSDIHLGSFMLPQYV
                     KEMLDEE"
     gene            complement(34669..35082)
                     /gene="speD"
                     /locus_tag="KR257_002029"
     CDS             complement(34669..35082)
                     /gene="speD"
                     /locus_tag="KR257_002029"
                     /EC_number="4.1.1.50"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418655.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="adenosylmethionine decarboxylase"
                     /protein_id="HBH0030731.1"
                     /translation="MKFETLGRHILVEYYNCDENVLKDPRLIENFMNDSALNAKATIV
                     DSVFHHFNPWGVSGAVIIAESHLTIHTWPEYGYAAADFFTCGDIDPWKSFELLEQLLK
                     SERSESTEIPRGLTTKIKKYSKKDLGKITHKPEAV"
     gene            complement(35169..36644)
                     /locus_tag="KR257_002030"
     CDS             complement(35169..36644)
                     /locus_tag="KR257_002030"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895922.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aminotransferase class V-fold PLP-dependent
                     enzyme"
                     /protein_id="HBH0030732.1"
                     /translation="MDSEFANAVELSYECAPLLESLKEYSEKDIACFDVPGHVKNRGV
                     AILNKYLGESLMKMDINSSPTMDNVSAPNGIIKNAQDLLAQAYMADEAFFITNGTTQA
                     IHAMILSVIKPGEKVLLPRNIHKSVINALILCGGIPIFIQPEFDEKLGISLNITLEKV
                     RTEIEKDCNIKALFFLNPTYYGVCADLESIIELCHKNNVLVLVDEAHGAHFPFHLDLP
                     PSAISLGADMVAVSIHKTGGALTQSSALLLNRDNVSFEKVLQSINMLQSTSASYLLMA
                     SIDGARVNLVENGEKQLSKALNLSRYAKSKLNKIDGIKVLSTEILKQKGVKFIDETKL
                     CINVKELNLTGFEVYDLLYKNFSIQVELGDSYNILALVSIGTNKSDIDRLVKALSIIA
                     KIYRKESTLNEFNMVQINPIIKLNPREAFYAPKESVEINSCIDRICGESIMAYPPGIP
                     IIAPGELITEEIMEYIIFLKNSNAYLTDVQDKNLDRILVIK"
BASE COUNT        11950 a         6668 c         3826 g        14569 t
ORIGIN      
        1 ctttttttat taactttttt ataattataa taaaaatata taacagtact attataaata
       61 cacatttaaa accttataaa tatacaaata caattatatg aattttcatc ctcaattata
      121 gcatagaata tgactatcta tatcctaaaa ttatccattt ctaaaaaaaa ggtaactatt
      181 attaagaata tcaacttata gaatttatat tccacatacg attttcaatc aaaaaaacaa
      241 gggctaaaaa gtgaattgtg cactttttag ccctttatta attattcatt tatttcatgt
      301 aagaatagac cacatcttac tttaggttca aaccatgttg acttagctgg cattatctta
      361 tttgcatctg ctactcttat taaatcttca atactagtag gatacattgc aaatgctact
      421 ttcatatctt cattaactct tttttctaat tcttcaagac ctctaattcc accgataaaa
      481 tcaattcttt tatctactct aggattatca attcctaaaa tagcatcaat aacatagtct
      541 tgtaatatag aaatgtctaa tgagtcaaca gggtcttcta tttctaataa atttttattt
      601 gctttcattt tataccactt atcacctagg tacattccga aagttccttt tttgtcaggt
      661 ttatattttt cttttccttc tatttcttct agttcaaaat tttcttttat tttatttata
      721 aattcttcct cgcttaaacc atttaagtct ttgataaccc tattataatc caaaaccatt
      781 aaattctcat ctggtgcaat cattgctatg aagtaattaa attcttcttt tccagtataa
      841 tttggatttt tagctctcat ttctttggct acattttctg ctgaagctgt cctatgatga
      901 ccatctgcaa tgtatagata atctaatttt tcaaatttat ctactaggtt atctattata
      961 tcatcattat caatcttcca tactgtatgc tctatcttgt catctgttat gaaatcatat
     1021 aaaggttcat tattatccat aaaatcattg attatatcat ctatcaccct ttgatgtttg
     1081 taagttacaa gtatagttcc cgtattagca tcacagtatt ttatgtgttt agttctatca
     1141 atttcctttt ctggtcgagt gtactcatgt ttttttattg ttccattcaa gctttcatca
     1201 actgatatac atgctactat accaacttga gctctaccat ccatgatttg tttatatata
     1261 tatatacact ctttgtcatc ttttactaga atttcttgtt ttcgaaactc atctaaattt
     1321 tctcgcgctt ttaaataaac tttttcatca tataaatcta tattttcatc taaatcaatt
     1381 tctgatttat ctatatgcaa aaatgaatat ggattccctt ctgcaattct tctagcttct
     1441 ttactattca taacatcgta aggaagtgct gctactttat ctactatata tttatttggt
     1501 ctaatcgcct taaatggttt aatcgttgcc attactaatt tcctccctaa ttatacaaaa
     1561 tattttataa tgctacccct attagattgt tgaagtcaag aaagaaatct tgaatcacat
     1621 ttactatttc gtctcctatt ctttcttgag cttctactgt agatgcccca atatgaggtg
     1681 taggagaaac tcttggatga tttactaagt ctaaatttaa tgtaggttct tgttcataaa
     1741 catctatagc agctgctgat aatttacctt catctaatgc ttttagtaaa tctttttcat
     1801 caactaaacc gcctcttgca cagtttatta aataagcccc tttcttcatc ttatttattt
     1861 ctttttcagt tattactgcc cccttattct tatcaaatgg tatgtgtaaa gataagaaat
     1921 ctgcattttc taaaacttct tccatatcac agaatttata attgttaaag ccttgcgcct
     1981 cacccattat gtcagtatat ataacattca tacctaataa ttctgctctc tttgcaactt
     2041 cttttgcaat tcttccaaaa cctataagtc caagtgtctt tccattaatt tctgtacctt
     2101 tatacttttt cttctcccat tttccatctc tcatagttac atttgcagta tttatgaatc
     2161 ttgcaagaac aaataattga cctattgtaa gctctgcaac agatatactg cttgcatttg
     2221 gagtattcat aacttttatg ccattagctt gagcatattt aacatctata ttatccagac
     2281 ctactccacc tcttactatc aacttcaact ttttaccctc taatgcttta tctattacat
     2341 ctttagtaac tttagtagct gaacgtacta caagtacatc aacatcttta agtttatctc
     2401 ctaaaacatc tttttcataa aactgctcta tcacattaaa atctaactct ctcaattttc
     2461 tcgctgcttc tttctctatt ccatcagtaa ctaatatatt atacataaca aactcctcca
     2521 atttttattc acttaatttt tccaattttt attttttaaa gtattttcat caataaaaaa
     2581 ctttacttaa tttaactttc tgtttatata attttcaaaa tattttttta ttaaagtcat
     2641 atcaaatttt cctattgttt gttaaaaatt taatatgtaa tttttataaa atattattta
     2701 ttatatattc taaatttatc ttaaaacata catattttta caatattatt tattaaaacc
     2761 taatatatca tcaatattat ctaataattc ttgtacatct tcgacagtat agtcacccat
     2821 atgtgaaatt ctaaaagttt tttcttttaa atctccatag ccatttgcta tttggaatcc
     2881 tcgttcttgt aattttgaat ttaaatttga tacactaata ccttgagtat tttctataac
     2941 agtaagtgta ttggataagt gattttcatt ggtaaaaatt tggaagtgtt ttttagccca
     3001 gtttctaact aagtttgcca tgtcttcatg tctgttgaat ctgttatcta ggccttcatc
     3061 taatatatta tctaattgga aatctaaagc gaacatgtga gaaagagatg gtgttgaagg
     3121 gtattggtag tttttcttga ttaagtattc atacattgct aacaaatcaa gatatactcc
     3181 tctaaaaggt acttgcttag ctctatcgat tgctttttga gaaaatgtgc aaatagacat
     3241 tcctggtggt aatcccagtg ctttttgtac tgatgttata caaatatcta ttccaatctt
     3301 atcaacctcg acttttattc caccggctga acttacagta tctacacagt agattacatc
     3361 ttcatacttt ttaacaactt ctccaatttc ttctattgga tttcttattc cagttgaagt
     3421 ttcattgtga gttacagtta ttaaatcgta ttctccggta gaaagcacct tatcaaccat
     3481 ttctggcgtt gttgcctctc ctaattcaac tttaaatata tccgctggga cattattagc
     3541 cactgccatt ttgtaccatc tatcaccaaa ggatccacag gaaaatactg ctgccttttt
     3601 ggatgtacag gaacgaatgg agccttccat taaaccagtt ccggatgacg tggataaaag
     3661 tatcgtgttg tttgtataga atagtttttg catcttttca cttatactct tttggagcat
     3721 agatgcatct tttcctctat gtcctatcat tggtgtagcc atcttttgca agacttcttc
     3781 tttaacatca ataggaccag gaataaataa tttcttactc attataattc cccccttttt
     3841 agtttgtaat atggatagcg tttttactgt ccttattttt aataactata atatcaagct
     3901 gaattaacta tgtcaacata aaatttattt tttatatata atttatttta tatattttat
     3961 gaaaacattc attttctacc ttttcataag tctgaatttt ctgaattatt ctctcaaaaa
     4021 aaatatactt tttatctata taaattaatt tttttagtat gtaaatttga cgctattacg
     4081 ataaatcttt ttagtataac taatttattt ttatcttgta tttttattgt atttttgaat
     4141 tttatttttt ctaaatataa aatttatgtt ttaaaatgta aaatttttat ttaatcaaag
     4201 ttcaatatat tccacttttt ctttcgattc ttcaaaaaac cattcttcat tagaaaaatc
     4261 accttctgca atttgtccaa taggcatttt catatacttt ccagttgctg tcactgctat
     4321 atctccattt ggtagaatta tttctcctgt accttcaaat aattttctgt tttctttagt
     4381 tattcttcca acaactttta tagtagcatc tgttggtact ggtttcttat atttcaactc
     4441 taaagatact gttactcccc atatttggtc atcatttata cttacagctc ttccaatagt
     4501 ctcatccaat attgcagcag acatacctcc atgaactctc ccaggataac tttgatgcca
     4561 atcctttgta ttacaaattg atacaagctc tccattttca agttcataaa aatctgcttt
     4621 aagtcctagc tcattttgtg ttccacaaac taaacaagat ttactactat tttgcttctt
     4681 caaaacttta tactttgcca aaaaatccat ctcctaaccg acattagtag tcgcttaata
     4741 ttaaataatt ctaaaatata ttatataata ttaataaaat ccctgcaaac ttctaataat
     4801 aaaaataggc tacttcaata tgataagttt aatttaaagt attattttcc aaaaaataac
     4861 tttatcaaaa tagaaactca aagtagatat aaacctcttt ttcgttatta aaatagtaaa
     4921 aatatatttg acttaatata aaaaagagtg tctcattaac taataaagtt tattttgaga
     4981 cacccctcat aaaacaaatt atactacaat agatttttac taattctaca agttatatat
     5041 ttaaattata ttattcaaat taaactataa ttctaaattt catttactat taattcgccc
     5101 atttcccttg ttcctacaac atttcccaca ccattataga tatcaatagt tctataacct
     5161 ttattgagta cactttgtac agcatcttca atacacttag cttcttcttc taagttaaaa
     5221 ctatgtctta acatcatgct tacagataga atagtcgcaa ttggatttac aatatctttt
     5281 ccagctatat caggtgcact tccatgtatt ggttcataca taccaaaact atcttctcta
     5341 agtgatgctg atggtaacat acctatagaa cccgtaatca tagatgcttc atcagatatt
     5401 atatctccaa atatattatt agtcactatt acatcaaatt ggctagggtc ttttacaact
     5461 tgcatagcag cattatcaac atacatatgt gacagttcta catcttcaaa ctctttagct
     5521 aagtcttcca ttatacttct ccaaagtctt gaactctcaa gcacatttgc cttatctaca
     5581 cttataagtt ttttatttct atttctggct atttcaaaag ctctcttacc aattcttctt
     5641 atttcatttt cgttatatat ttctacatca taagcatttt cgataccatc aatgattttt
     5701 cttccacgtt ctccaaaata aatgccccct gttaattccc ttacaacaac aaaatcaatg
     5761 cctttctcaa ctatatccgt tctaagtggt gaagcttctt ttatactttc atacattgta
     5821 gctggtctta aatttgcaaa taaacccaat gactctctta attttaaaag accagactct
     5881 ggtcttttat ctcccttaca tttatcccac tttggtcctc caacagaacc aagcaataca
     5941 gcttcgtttt ttcgacaagt ttcaacagtt ttattaggta gaggttctcc agtttcatca
     6001 atcgcgcatc ctccagctaa tacatattca caatcgaatc tatgattaaa tttacaacaa
     6061 attttattta gaacctttat accttcatct ataatttccg gtccaacacc atcacctttt
     6121 atgactgcta tattacaatt catactccac taccccctat ttgcttttat tgagttaatt
     6181 aagccttcat ttaatataat attttgcata aactcaggaa atggttctgc tttatattct
     6241 tttccttttg ttatattttt tatcacacct gtagaaaaat ctacttctat attatcccct
     6301 tcatctatgt tattggcagc ttcttcacat tcaagtatag gaagccctat atttatagag
     6361 tttctaaaaa atattctagc aaaagtagaa gcaatcacac aggatactcc actttctttt
     6421 attacaattg gtgcatgttc tcttgatgaa ccacaaccaa agtttttagt tgcaactata
     6481 atatctcctt tttttacctt agaaataaat ttatcatcaa tatcctccat acaatgcgtt
     6541 gctagttctt tataatcagc tatatttaaa tatctagctg gtattattac atctgtatct
     6601 atattgtcac cgaatttaaa aacacttcca ttggcaatca taaattttac ctcccttaaa
     6661 ttatttctga tggttttgat atttttccag ttatagctga tgctgctgct acagctgggc
     6721 ttgcaagata cacctctgaa tcaacatgcc ccattcttcc tacgaaattc ctatttgttg
     6781 ttgaaatgga tttttctcct gctgcaagta tacccatatg tccccctaga catggaccac
     6841 aagttggtgt agaaactgct gctcctgcct ctataaaagt ggtaatatac cctttttcta
     6901 tagcttcaag atatactttt tgagttccag gaaatatcat aactctaact ccatctgcta
     6961 cttttttgcc tttcattatc tcagctacta cttcaaggtc tgatattctt ccatttgtac
     7021 aagagcctat tacaacttgg tctatcttta tatccttatc tatctcatct actgttctag
     7081 tattttcagg aagatgagga aaggctactg tttcttttag ttcagctaaa tctatttcgt
     7141 atacttcatc atagactgca tcttcatctg cttcatatat atttacatct tttgtcatag
     7201 ttgaacactt atgtgaattt atatattcca tagtcttatc gtctactgga aaaattccat
     7261 tttttgctcc tgcttctatt gccatattac aaatagtaaa tctatcatcc atagataagt
     7321 attctactcc atctccacaa aattccattg acttgtaaag tgctccatca acacctatct
     7381 cccctattat atgaagtatt atatctttac cacttatcca tttatttggt ttattcttca
     7441 aaacaaattt tattgctcca ggaaccttaa accaacattt tcctgtagcc atacctgctc
     7501 ccatatcagt tgaacctaca ccagtagaaa atgctcctaa tgctccatat gtgcaagtat
     7561 gagagtcagc acctataatt acatctccag cagttactat acctttttca ggaagaagaa
     7621 catgctctat tcccatatct cctacatcaa aaaaatttac aactcctttt gattttgcga
     7681 aacttcttgt aaatttacat tgttctgcac tctttatatc tttattaggt gtaaagtggt
     7741 ctaaaaccat cactacttta gtcttatcat aaacatcttc aattcctaat ttttcaaatt
     7801 ctctaatggc tactggtgat gttatatcat tacctaaaac tacatctaaa tctgcttcga
     7861 ttaattgccc tttcttaact tcatttaatt tagcatgttt ggctaatatt ttctgcgtca
     7921 tagtcatccc cattttttat ttcctcctca atataacttt tatttattgc attcataagt
     7981 gcattaatag ctgctgtatt tatgttttcc gatatactta caccaaaata gacttcatta
     8041 ttgtgctcta ttcctacata agctacccct cttgaatgtg acccttcctc taatgcatgt
     8101 tcccagtaat atctaaattt ataatctttc atgccacatt gctttagtgc attattaaat
     8161 gaatctacag gtccatttcc tataccaaca atcctttgtt catttcccat ataacttatt
     8221 cttgcagtca tctcaatcat attagtatca ttagaatcat cattttcata gtttaattca
     8281 tccattgatt ttattttata cttcttaact ttataagggc tctcaacttc aatatattct
     8341 ttcttaaaca aattaaatat tgcttcacta ctaagttctt ccccaattct atcagattcc
     8401 attttgacta catttccaaa atcagaatgc atatttttag gtatcataaa tccataatct
     8461 gtttccatta tataaacagc tcctcctttt ccagattggc tatttatcct tataatttct
     8521 ttgtattctc ttccaatatc atgagggtct attggtaaat atggaacttc ccagtaatca
     8581 ttatctctgt ttttcattgc tatcatgcct tttctaatag catcttgatg tgaacctgaa
     8641 aaagcacaat gtacaagatt acctgcatat ggatgtctat catgtaccat aagttttgta
     8701 cagtcttcat atatacctat tatcttatct atattgctaa aatctagctc tgggtctatt
     8761 ccttgtgtat aaagattaag tcccacattt actatatcca tattcccagt tctttcacca
     8821 tttccaaata gtgttccttc aagtctatcg gcaccagcca ataatccaag ttcacttgca
     8881 gccgtacaag ttcctctatc attgtgagta tgcaaactta gtataataga atccctacaa
     8941 cttatatttt tacaaaacca ttctatttgg tctgcatata cgtttggtgt tgccatttca
     9001 actgttgatg gaagatttat tattactttt ttttgaggag ttggtttcca aacatctatc
     9061 actgcctcac atatttcaag tgcataatcc atctctgttc ctgtaaaact ctctggtgaa
     9121 tattcaaaag taaattctgt ttctggatat ttttttactt cttcattaaa taattttgct
     9181 ccttcaactg ctatatctat tatttcttgt ttactcatat taaaaaccac atctctttga
     9241 agaacagatg tagagttata taaatgtata attgcttttt tacatcccct tattgattca
     9301 aatgtttttt ctataagatg agccctagat tgtgtaagta cttgtatagt tacatcatct
     9361 ggaatcatat tctcatctat taattttctt aaaaatgtat actctgtatt tgatgctgat
     9421 ggaaatccta cctctatttc tttaaatcct gtatcaataa gcattttgaa cattctgact
     9481 ttttcattta cactcatagg tgttggcagt gactgatttc cgtctcttaa atcgacacta
     9541 caccaaattg gagccttaaa tatttcatta tctggccatt tacgatttac tatttgcatt
     9601 ttatcatatt ttttatactt tccacacttc atgttatttc cccctttttc tgttttttgt
     9661 attcagtata cctcatatcg acgcaatcct gcacaattca taaggataaa tgtcaatttt
     9721 atcattagaa taaaaaaaac ctcatctcta ataaaattag agacgaggtt ttgctcgcgg
     9781 taccactcta tttagctttc taaaaagctc ccttagtaat agccaataca ataattataa
     9841 tgactatatt tcctataacg tggaattact ccgattattc taagatttaa atcttagaaa
     9901 acagctccta gacaagttca gaactatcaa ctactaaatc acaccatcct ttagctctct
     9961 gaaagtttca ttgttcttac tacttctatt catcactttt ttaatcattt aaattttcta
    10021 aatattttga tttaatagtt attatataca cattaaaatg tattgtcaac acaaaaaata
    10081 attatctcaa ttttttattt ttgataagca attctataaa acatgctaac tattgaaaac
    10141 agtatgatat tatgccttaa actttttcat cttttcatct atgatattca ataatttttt
    10201 ttcatcttcc aaactcaatg cccttaatct aattttataa ttagattcgt tagtgtatat
    10261 atttaatata ttttttacta cttctatttt ttctattatc ttataattaa acttttgact
    10321 ttgtttagat tttatactga atatacattg attatttatt aatattgaat gattatcgag
    10381 agtaatatat acttttccct catatttatt tgaaaaatca cgaccttgtt taaatagaaa
    10441 aactgctgtt attatacata aaatatataa tattgtcgtt gaatatataa aaattgtagc
    10501 taaaattata agtgctaaaa ccatatatat agtcattcct tttttaaaat aaccattgtc
    10561 ataataattc atatagataa acttattttt actcaaattt tttcactccc aagattctaa
    10621 aaatttatat caaaaaattc tataatttca tcttcatgat aatttatgac taattcatct
    10681 ggaaaatcta ctgcttctaa aactttttct gcattttcaa attctcctat agaataacat
    10741 atatgagagt cagtaccaag aattactctt gcaccatatg ttttacacaa tgtcaacata
    10801 tgacttacat tttcccaagt acccgttcta tgagagtttg aacttaatga tgaattattt
    10861 atttctaaaa ggatattttt atctttagct ttttttacta taggttcata atctaaagga
    10921 tacctactgt catctggatg tccaattatt tttaccttag gtttatccat aacttttaaa
    10981 atagcatttg tattttcttc ttttgtacca gaagctatac aaggtctatg caaacttgcg
    11041 attatataat ccaaatgttg caacatatct tcttgaacat ctaaattacc attataatcc
    11101 attatatttc cttctattcc tctaagaatc tttacgcctt gcacttcacg tggaagcaaa
    11161 tgcaaattat aaaaatagaa tggatgtggt cctcctggca tattaggtcc atggtctgat
    11221 attcctaagt attttatatt cttcttactc gcctcttcga cattttcctt gaaagtacta
    11281 tgtgcatgtc cacttattag agtgtgacaa tgtacatcca taatagactt tttcattaaa
    11341 tttcctccta atattttaca taaattcgtg aaaatagcta aagggctatt tcaaaactaa
    11401 agctgtcata atagacagtg taacgtttta aaacagcccc attttcaatt attttacact
    11461 tctaaatctt taaatttatc tttaaataat tctccaatac ttcctaaaga ttcctctact
    11521 tctaggtatt ctgttatatc ctcttctggc tctctagttg cttcttttat tgaaaccaac
    11581 attctcttag tctttggttt aaaatcaaga atcttaactt taacctcatc tccaatatta
    11641 acaacattag taactttagc cactctagta tcactcaatt cagatattgg taaatacgca
    11701 tctacacctt ctttaatttg aacaaaagcc cctttttcta ttattctaag aactttagca
    11761 ttgacaacat catcaatttg tacttctttt gctattaaat cccaagggtc attatttatg
    11821 tcttttaatg ccaaggcaat ttttttagtc tctttattta catccaacac ataaacttct
    11881 acttcttgtc cctctgaaac aacatcttca acactttcaa ctcttgtcca agctaaatta
    11941 tttatatgtg ctaatccttc aatcccacca atatccacaa atgcaccata aggcattatc
    12001 tttgtcacct taccatctct tttttgtcca acttcaagag aattaaataa gtcttcttta
    12061 gctgctttga tacgagcttt ttcttcttct ctttcttgct taattcttgc tctttcagct
    12121 tctttttctg ccttaatttg agctcttctt tcttctctct ctttatttat acgctcttgt
    12181 aatacatctc tatgagatgc tacaagtcta ttttttctaa catccaattc ttttatataa
    12241 acttctaagt taagaccaac aaatttagat gtatctgtaa taaattttgt atcaagttga
    12301 gaaattggta taaaaaatgt atatgtattg taattagcaa atacaccttt atctatattc
    12361 ttttcaacat ttacagttat tattctatgt tcatcataag ccttttgtaa ctcggcaaaa
    12421 tcatttcttt tgtcaagttg taatttagat aaagttattg taccatcttt ttgagatact
    12481 tttgttatta cagcagttat ttcatcacct atgtggtata tatcttctat atattgattt
    12541 ttttctatgt tcaattcact tataggtatt attccatcaa acccatagtc taatcctaat
    12601 tgtacttcat catttctcac tgcagttatt tttccagttg tcaattctcc aactttcact
    12661 ttgctgaata cttgttcttg ctggtcaagt aattcttgca ttgttaaatc attttccatt
    12721 ataaacatcc tttcctctta ttgattatca tatctgtaaa tattatacca ttaatattgc
    12781 aaatacttac atttttctta ctataatttt taaaataaat tcaacttcat atatttatac
    12841 attatagaaa atatcttatt aaattaaaat acaaattcta atttttatct aataaaatat
    12901 tttcataaaa aatttatatt gtatatctta ttcttttatt gctttaggtt ttgatagaaa
    12961 acatttataa aatataaaga aagaaattgc tgttatagta gcagctgtta tatctgcaac
    13021 tggctctgct aaaattactg caaaaagttt ttcattaaag aatgttggaa gtataaatat
    13081 taaaggtatt aaaagtacaa tctttctaag tagagctaaa accaaagata ttgttgcttt
    13141 tccaagtgct aaaaatgtct gttgacaagc tatttgaatc ccaaacataa aagcaccagc
    13201 aaaatatatt tttatactcc aactagtcat actaagtaac tgcggattct tattaaatat
    13261 actaacaaaa aatgcaggaa atatcattaa taaaagccat aaaatagtag aatatgtaaa
    13321 acatgacaac aaacacaact taaatgtctt ttttactcta tcaagttgac ctgaaccata
    13381 attataactt attattggtt gtgctccttg tgtaaccccc atattaggaa gcataagaat
    13441 ttgcattata ctgctcatta tagccattga acctactgct aaatctcctc catacatttg
    13501 taatttacta tttaaggcta taagtactaa actttctgta gattgcatta taaatggaga
    13561 gattcccaaa ccaagcactg gtaagatgat acttgctttt ggtatcatat acttcttttt
    13621 tattttaagt atacttttct ttccaaagag aaacataagt acccaaatag cagaaacgcc
    13681 ttgtgcaatt atagtagcta atgcagctcc ttttacaccc atattaaagc caaatataaa
    13741 aatcgggtca agtattatgt ttattaaagc acctatagca actgtcatca ttccagttgt
    13801 agcaaaccct tgggtattta taaaagtatt catacccatt gaaatctgaa caaacactgt
    13861 acctattaaa taaatattta aatagtccat tgaatatcca attgtagatt cacttgctcc
    13921 aaacatccaa agtaaaggct cttttccaat cttaaaacct atagtcaaaa gtattgctaa
    13981 aatcaccagt acagaaaaac tgttactcat tattttctct gcctcatcat tgttttgctc
    14041 acccattttt atagcagcta atggacctcc tcccataccg attaaataac tacatgcagt
    14101 tattataatt attattggaa atgccactcc aacaccagcc atagcaactt ctccattttc
    14161 cattctacca ataaaaatcc tatcgactat gttgtataaa acatttacaa tttgtgcgat
    14221 aatagcaggt gtagcaagtt taaataataa tttacccaca ctttcactac ctaagttagt
    14281 gtttgaattt tccattttaa aacctcctca atccaataat taaaatgtat cactaaaatt
    14341 ttattctata taaaaatttc attttattag cagacaaatt tagagtactt tccctacaag
    14401 taatactata ctatatttct tttgccatag taaacatttt agaactaact gaagttaaat
    14461 actttatctc attttttatt tattattaaa aatttttcac acatactcat aaaaaaacta
    14521 tccaagtata ttacttagat agttttatat tatatgtaaa gaaagagctg aaactataac
    14581 ccctgataac aaattgccaa gaaatactcc cataaaagca tcttttattc tcatttttaa
    14641 tatggaagct atagcagatg cagtccacgt tcctgtagtt ggcagtggta tacctacaaa
    14701 tagtattata ccaattatcg aaacactttt taatttcttc attcttgagt ttatttttct
    14761 atcaattaca tcagcaatcc ctttaaatag tttcttccct cttaaaaatt gtaatacatg
    14821 tctgaatgtc aatatcaagg gaatcgatac caatgtagaa cctattacac taaatacata
    14881 aacccatata ggatttaagc ccattgcaat acctatagga atggctcccc tcaattctgt
    14941 tacaggaacc atagataaaa ttaatatgtg taaatatccc aaactattcc ctcctattct
    15001 aagtgacatt aagttatgaa tttatttgct ctataacctc accatccttt ttactaacta
    15061 aaaatgcatt tttagtcaat gaaagcattg gtaaatcact cttagagtct gaatatgcat
    15121 atgaattttc ataatcaatc tctatcccaa gtttacctaa tacagccttt attcttttta
    15181 ctttttcaat tcccttacag ttttctccaa tgaatttatt tttatatctt gaattttcat
    15241 aaaaaaactc cgtgcctata acctcgtctg caagaccata atacttaaaa tatttcatat
    15301 atgcatatgg agatgcagtt atcataatta taacattatc ttcttcttta tttttgtaaa
    15361 taaccttttt catagattcg ttaatttttt tcattatgca atcatcaaaa aactttttta
    15421 aatcttcttc actaaaatct actattggat aaaagattgc ctcttttgcc ttcttcaatg
    15481 gtattattct aattaaatac ataaatagaa taaaaataat gtatggtaac tttataatag
    15541 ttttaaaggt tttatttttt aaagagtaaa taaaaaaatc tatcatgcta tcagtattta
    15601 taacagtata atctacatca agtaataata cacttttttt cataagtatt tccccatcct
    15661 atcactaaaa atatcactaa aaaatcaata ttattaaaca tgtaattatc cataagatta
    15721 cgtttatttt taaagcatta tcttttaaga caatatcagt aggattattt tcatttgtag
    15781 tgttaattat ataattatat ctaagtacac cataaactac aaatattgtt gtaaatatca
    15841 tatgtggctt ttctggatta cttgtagaat acaatgcata acatacaatt gtagaactta
    15901 atataactat catcatttga tttagatttt ctatgtcata atcttccaat atttttctat
    15961 gttcaactgc atcatctctt agagtttcta tttctttttt acgttttcca agagctaagt
    16021 acagagataa gaaaaatgta cataaaatta tccaatttga taaactaaca cttatggcta
    16081 cacatcctgc ataaacccta agtataaaac caagagatat tgaaaacaca tctaatagta
    16141 ttatattctt tagtttaaga gaatataata tattgtttat caaatagaga ctgagaatta
    16201 tagaaagatt aaaactaaca actgttgata aacagactga aattaaagct aatactacaa
    16261 atagtatatt agcacttttt ttgcttattc ttccacttgc cactggtcta ttacattttt
    16321 taggatgttt tttatcttta tccatgtcta tggcatcatt cagtgcatat actgatgatg
    16381 acattagaca aaaacacaca aacgcaataa acgtatttaa aaataaattt atatttagta
    16441 tgttgtttga aaaaattata gctgaaaata caaagaaatt ctttatatat tgctttattc
    16501 tcattaactt tatataatct gaaattttag taagaagcct tatacttgta ttggtctgtt
    16561 tcataaactt actacccttt caatattatt ttttaaacag gatatgattt tatccctatg
    16621 tttaaaattt ctataaatcc attgacatta ctgattacta tagtaaccaa taacagcgat
    16681 agaaatatat tatacatatt cttttcattt tttctaagcg ctttcgtaaa gtaagccaat
    16741 aaaattataa ctgcaaaact aaaatttata gccataatac ttgaattgac tagattatat
    16801 cctactatac catgtaaagt tagattgaat ataattattc ccatacatag cttaggaact
    16861 cttttttctg aattttcaat aactgataaa acacaaaaac ataaagctaa taatgtaaga
    16921 attactggta ttgtagcaac ttctccattt tgcaaaaata accctttttt aatacttgct
    16981 ccaggaaaat aaaaaaccga atacaataat ctctctataa tcattgcaat cttttccaaa
    17041 attggttctc cacttataaa tttcgtatca tactgtatta catttccaag gttcataaaa
    17101 ctctcataag actttgttga aactacacaa atatatgcca ttaggataaa tgtaattaaa
    17161 tgttttaaca tttttcctat ttttaattta aactcaaata tcatattaaa aaaatacaaa
    17221 tatatattac taatagttat tccaaataga ggaatagctg ctaattctac taaataagaa
    17281 ttttttcctt tcatcttatt tgcaataact atgaaaaata ttaatgaaaa ttggctatat
    17341 ataaatctct ctacatttaa agtcataaat aactgtggaa aagaaaatat cattatcata
    17401 gtaagtaaaa ttaaagttaa tctctgcatt tttatctttt taatatgatt aaagactaaa
    17461 gttattgaca tagcactagt tattatttgt agacaaatta gtccaaaccc ataggcacta
    17521 ttaaaatctg ttgtcccagg atttgctatt gaagtacaaa ataggtatat tggatatgca
    17581 aaaattgata taattgctga aaacaatatg tgcttactat tgtcttgact tatagcaaat
    17641 acatttaaat tgaataaaac tcctgtatct gtatctaaca atacatcata agtattgttt
    17701 aaatcataaa atatagtagt cttagaaaaa aatatcttag ttattattaa gtaagttatt
    17761 acaactaata taaacaaaaa catctcgttt ttatatttta atattttact catcaatata
    17821 tcaccatcca ttcattatat aggatttgct gacacctaca atttattcct tatatttaat
    17881 agccatcttc ataatgttct tacttgtttt attgtaattg aataactctt tatttacaac
    17941 cacaatattt actttattga tgttataatc agtcaagtat tgtttatata acatagatta
    18001 gtgttgtata aaatgagaat ttgtaagcaa tattaatgta aaatatttga aaaactttat
    18061 ataaaaatat acaatgttgc ttatggaatt aaactataac aaattaaagc ataatttaag
    18121 gagacaaaat tataatctgt ctccttaaat attaaaacta tattttaaaa cattactaaa
    18181 tactatacaa atttcaaata tagtataaaa ttaattagac tttaacacta ttagctccat
    18241 cttcttccca ttttttaatt tcttttaatc tatctattat aggtaaatgc tgagtacatt
    18301 caacttcaca ttttccacaa gatatacatt ctttagcttt tgccttacta ttcattgtgt
    18361 aattccaatg tcctaagcca taaactaact ttgtcatttc ttcatcactc tttttaaaca
    18421 tctgcttttc attataaaaa agcatatagg ctggggtatt aatacctttt ggacatactt
    18481 tacaataacc acaacctgta catatttcgt tcatattctt atttaatcta gtctcaatat
    18541 catgtatatc ctcatctgaa taaattctat tttcgtctgc aattttacat gcatcatcta
    18601 tatcttgttt tttattaaac cctatcaaag atatacttat ttgtgaaatt cctatgttga
    18661 atcttaaagc tgattctata gtactttcgc catcttttga tagaaaagaa agttctttat
    18721 tatactttgg aatagttcca ccacttaatg ggttcattgc cacaacacca tatccattat
    18781 caacagcata tttggcacct tttagcctat atggaaagtt taatatattt attcccatag
    18841 ttacaccttc aaacttattt tcacttagaa tatctataac ctcatctcct ggttgatgag
    18901 atgaaaatac tatatggtct atcaatcctt cttctttaca tttcaataat ccttcatatt
    18961 gacctccagg tctcattgct agttcgtaat gttccatctt tctaatattc caaacatgat
    19021 aaaaatttat tttagatacg cctaatcgtt ctattgattt ttttacagcc tctatagctt
    19081 tttctgatgt atcacatgct tttggctttt ctttagttga tacataaaaa tcggtcttac
    19141 cttcctttat catttgtcta aaggctagtc caaatatatc ttcacttctg tcatcacaat
    19201 accctggtgc tgtatcaaag taattaatac ctttttcata cgcatatttg actaaatcag
    19261 cattttcttg attacttttt tctaaatcaa accttaatcc tccatagcca actactgaaa
    19321 ccattttccc tgtctttcca tattcaacgt atctcattgt aaattcctcc ttagatatat
    19381 taagacttaa tttctttata gaaaatatta taccataaat aatttttata aattatttat
    19441 ggtataatat tttttttata aattatattt ttttataact tgtattttat aactaagtta
    19501 aaaactataa aaaggttcaa tatggactat tacttgagca ttttcattaa tttcttcttg
    19561 tatttgtttc tcaattttat gtgttaaatc atgagattgc tctacgctta taaatgggtc
    19621 taccattaca tgcatgtcaa tataaataga acttttgcta cctctacttc tgatattgtg
    19681 aacatccctt acctcattaa attcaaacac aatttctttt atataatcct catctacagc
    19741 cactctatcg accaaaattc caatagatgg cctaaatatt ccataagccg aataaattat
    19801 gaatgcagaa ataataatag gaactataga ttctattatt actggaaatc ctaacttaac
    19861 accaactaaa gtaaccaata cacctagaga cacaaatata tcacttcttg tatgcaatga
    19921 atccgaaatc aaaacataac tatttagttt agtcccaatt ctatattcat acatgcatac
    19981 aaaaatattt ataaaaagtg taataattaa agcaattaaa ctttctatag ttatagcagg
    20041 tacaactgga ttagctattc ttaacactgc actaagaatt atcttaattg ctataacaaa
    20101 caacatacca cttataaata aactggttat aatttcaaac tttttatgtc cataaggatg
    20161 atttttatct tttggtttag atgcaaagaa aatacctata agccccacta tattagatgc
    20221 tccatctgac aaagaatgaa atccgtctgc tgtcatacta tagcttttta tttgattacc
    20281 aataatgatt tttaataatg ctactgcaaa attagcaaat aaaattatcc acaatacttg
    20341 cttcactttc ttatagttat ccataacaaa ttccccctcc cttcgattca ataaagaaag
    20401 ctatctatca atatcaatca accagacaat aaaatcgtat ataagcacat ttactatatt
    20461 tatattcaaa attggttgta cttgttcatt ctatttgaaa cttaattata aataaaaatc
    20521 gtaggtatgg ttttggtata cataaaaata agagactgtc tcaaaataaa gataatcttc
    20581 ttttttattg ttgaaatgat aaaatatatt tgatttcata taaaaaagag tgcctcatga
    20641 actaaaaagt tcattttgag acactccctt aaatttttga tataaactat taatttttta
    20701 tactaagcct tctttaacta agaatgaatg agcaacttct tctggtgatt taccaagttc
    20761 atccacttga tagttaagtt ctctcatagt ttcttcattt atttttcctg aaagcatatt
    20821 cataactttt tctaactcag gatatttctt caaagtatct tctcttacta atggtgctgc
    20881 ataatatggt acaaagaaat ttttatcgtc ctctaatatc ttaagattaa actttttaat
    20941 aagaccatca gttaaaaatg catctataac ctgagattca ttattatcta aagctgtata
    21001 tcttaaactt ccattcattg cttttacatc tttgaatttt aaaccataat ctctagaaag
    21061 ccctacaaga ccatcttctc tattttcaaa ctccaaagtt ggtgagaatg taaattcttt
    21121 accatattta gtcaaatcag aaatagtatt tattccatac ttttcagcag tttcaggcat
    21181 catagctaat gtgtaagtat tattaaatcc aagagggtca agtaaagtta actgattttc
    21241 tttttccata gtatctttta caacattata tgcttcatca gcatctttaa tcggagcatg
    21301 tttcattaca tttaccaaaa gtgtacctgt atagtcaaca tacatgtcta actcaccaga
    21361 tttaattgca ttaaacgcaa cagatgaacc acctagattt aaattcttct taactttaag
    21421 attcgtattt ttttctacta attcagcata aacattgcca agtataagtt gttctgtata
    21481 atctttagaa ccaatagtta ttgtatcttt tttacttgaa aaactagaac taaaaacaac
    21541 gaacaacatt gaaacaacaa gcactacaga tattacttta agtgctatat aattcttctt
    21601 aggtgctttt ggatttaatc cttttggagt aactgcaact tcaattttac taaataaata
    21661 atcaactaac agtgcaatta tacatgatgg gattgcccct gctaaaatca tattattatt
    21721 tacagtttga acccctgaaa atactaaata tcccaaacca ccagcaccta taaatgctgc
    21781 aagagtcatc aaaccaacag ctgtaactgc agatattcta actccaccca ttattatagg
    21841 aagcgctaaa ggaaattgta ttttaaataa tgtctgattt cttgtaagac caataccttt
    21901 agctgattct aatactactg ggtcaatact tgttatacct atatacgtat tttttacaat
    21961 tggtagtaat gaataaacca ctaccataaa tatggctggt ttacttccta taccaagtat
    22021 aggtacaaga agacccaaaa gtgccataga cggaactgct tggactaagt ttacaaatcc
    22081 aagtacaaac tttctaagag atgagattct tgaaataatt attccaagag gaacaccaac
    22141 tattatagct attaaaatag atgtaacagt tagactcata tgttgtatta aaagctctat
    22201 aatcttatct ttttgtaata gtataaagtt aaaaaaatta gccaagaaca ctcacctcca
    22261 tttctaagaa ttgttcactt aaaacagaaa gtaaactact tctagtaata agccctacca
    22321 gtttattttc atcagaaata accggaatat atccaaccga attacgattc attacattta
    22381 gtatttctac taaattatca ccttcattta catgcaaagg ctcacttgac ataatatcag
    22441 caagtaatat tgacttatca tcaatatctt tcatatcttt tacagtaaca atacctttta
    22501 atgtttttgc tctatctata attagtaagc tatcaacctt actcgttctc ataatttcta
    22561 ttccttgagt tacagttcta gtagaattaa cagcaatagg attttttatc ataatatctc
    22621 ttgcttttat atattctgga ttatcccaaa ctctatcttc tccgataaaa tcttttacaa
    22681 agtcatttgc aggctttcta agtatatttt cgggagtatc atattgtgct attcttccat
    22741 ccttcataat acaaatttta tcagctatct ttaaagcctc atccatatca tgagttacaa
    22801 atattatagt ttttttcaat tcatcttgaa gagaaaataa ttgttcttgt aaagatgttc
    22861 tcgttattgg gtctaaagca ctaaaaggct catccatcaa tattatttca gcatcagtag
    22921 caatggctct tgcaacaccg attctttgtt gctgtccacc actaagttct gaaggatact
    22981 tattcaaaaa ttcatcacta tcaagtccta ccatctcaag tagttgcaac gttctttttt
    23041 caatttcttc aacggatttt tcctttttta ggcgtggaat tagctctata ttttctttta
    23101 ttgtaagatg agggaatagg cctgtgttct gtataacata tcctattttt cttctaagct
    23161 ctatttcatt ttcctgagaa attggtttgc cattaatata tatctcacca gatgtaggtt
    23221 ttattaattt gtttataagc ttcaaagtag tagtctttcc acaaccactt gaaccaatca
    23281 aaactaccaa tgtacctgtt tctacaacta gagaaatatc atctaatata acattatttc
    23341 ctattttttt tgttacattt cttatctcta tcataattta tcatcccctt tttcgaacaa
    23401 gcaaccttct tcaatattat aagttgtttt tataattata tcatactatt ttatttatgt
    23461 aaacaaagta cgatttttag gtcactattt gtctgaatat tgctacaaat ataaagtatt
    23521 tatatatagt atataataca taatgtcaaa aaacaaaaaa tataaaaata ttcataaaat
    23581 aacactagcc tcaattatat agtattaaag ctagtgttat ttcatttaaa caaaactcac
    23641 atttggatac tatccatgta ttcaaataat gtaatatctt tataagtttc ttttttatca
    23701 cttaggtttg atattgtaac tcccaatagc ctaatttgtt ttccattaac atcaacattt
    23761 ctcaacaaat tatctacacc acttcttata tcattatatt cgtcaatata gtgttctaaa
    23821 ctaaggcttc tagttatctt tgtaaagtcc tcatatttaa tttttaatgt taatgttttt
    23881 ccaaacttct cagagttttt taatctatga catacttctt cacaaagttc atcaagaatg
    23941 ttgcgtgttt cttcttcatc aatatccaaa ttatgactta atgtagtctc agccccaaca
    24001 gattttctaa ccctatttgg ttccactggt ctatcgtcta ttcctctagc aaatttatat
    24061 aattcataac ctcttttttt gaatatattt tcaagttcaa ataaatttaa acaccttaaa
    24121 tcatatccag tttttatacc taaattttta agagtatttg aagtaacttt tccaacacca
    24181 aaaaatttat tcacaggtaa tttatctaaa aagtcctggg cattttcttc ggttattaca
    24241 gttaacccat ttggctttct taagtctgat gcaatcttag caagaaactt attgtatgac
    24301 acaccagctg aagaagtaag accaacttct ctaaatatat ctttttttat ttgctttgct
    24361 atctcaattg atgaatcaat atttttttta ttttttgtta catctaagta agcttcatct
    24421 aaagataatg gttcaactaa atccgtgtat ctataaaata tatctcttat ttgctctgac
    24481 acactcttat aaacatcaaa tcgaggtctt acaaaaactg catatggaca cctattgtaa
    24541 gctacagctg atggcatagc tgaatggata ccaaattttc tagcttcata agaacacgtt
    24601 gcaaccacac ctcggctttg tggatttcca ccgacaataa caggtcttcc ttttaatttt
    24661 ttattatctc tttgttctat agatgcataa aaagcgtcca tatctatatg aattattttt
    24721 ctataatgtt tcattattat caccttttaa agtataaata gattaatttt atttatatta
    24781 ctttttaatt ataccaaact tatgtttctt tttggtattt tttcattatt ttctttatat
    24841 attcatattt tccataaata aaaccatcta taatccatta acttcaatat aatttataaa
    24901 aaatccttaa aaacacttgc aaaaactata taaaagcttt acaataggta ttccaaggaa
    24961 ctaaatttaa aattccttat ggataacagt atatatattt aatttatggg atgttttaaa
    25021 aacaaaagac tgtcttatgc aagacagcct actgatttta ttataattgt aatggactgc
    25081 tcaaactatt actttaaaac agcccatatt tttttatata attttaacta tagtaaagat
    25141 tttgtgaagg atattctggg tcacaagtta catctatacc aagctttcta aatgtttgtt
    25201 catcatctct atttaatata gtagtagaat gagcttgaca cccttttaat aatgctaact
    25261 tttccatagc aaattgtgca gttggattag ttacagcaca aatactaagt gcagttaaca
    25321 cctcttggca actaagtgaa acatttctac tagctaaagt ctttgttttt aagtttatga
    25381 taggttctaa tattacaggt gatattaagt gcatatcatc agatatattg gctaaatgtt
    25441 taatggcatt taatactact gctgcagttc cattcattaa atcagaaccc ttaccagtta
    25501 atattgtacc atcttctaat tctaatgcaa ctacaggaca agtatcattc ttgtcagcac
    25561 tttctttcaa tttattactg tagtttctag caggtaatac aacatttcta tcttctggct
    25621 ttaagttaag ctcttccata atcattttca ttctatcata agcaccttta tcaacttgtc
    25681 cctttttata ctcacaggca gttttaaagt atcttcttat tatttcttct atagaagctt
    25741 ttcttattac ttcatcatct attattccaa agccaactct attaacaccc atatcagttg
    25801 gagattggaa aattgattct tttccagtta tcttttctat tattttttta agcactggaa
    25861 ataattccaa atctctattg tagtttactg acatttcacc atacgtttca aggtggaatg
    25921 aatctatcat attcacatct tttaaatcaa ctgtagctgc ttcataagct atattcaaag
    25981 gatgttttac aggtacattc caaactggga atgtctcaaa cttagaatat ccaactacat
    26041 tacctctttt attttcatga tacaactgac ttagacaagt accaagtttt ccactattag
    26101 gtcctggtgc tgtgactact actattggct ttgtagtttc tatatattca tttgctccat
    26161 atccctcatc actaactata gtctcaacat ctgacggata tccctttgtt ggataatgct
    26221 tataaacttt aattcctcta cgttctaatt tatttataaa tacagttgta gcaggttgtc
    26281 cttcaaatct agtaattact acactattta catctagttc ataacctctt aaatcatcta
    26341 ttaatcttaa aacttccata tcataagtga taccaaagtc tcctcttatt ttgtttcttt
    26401 ctatatctcc tgcatagaca caaattacaa cttcaacttt ttctttcata tgttgtaata
    26461 cttttatctt tgcattttca tcaaatcctg gaagtactct ttttgcatga aggtctccca
    26521 tcaattttcc tccaaactct aaataaagtt tgtcaaaatt atttactctt tctaagatat
    26581 atttagactg ctcttctaaa tattttttgt ggtcaaatcc tactttcatc ttaacacctc
    26641 actaaattaa atttcttatt gataacagta tatttatata tattttttta gtaaaacatc
    26701 ttataaaaaa atgttaatac tttttcactc aaagtaatat tatacaatta agattaattt
    26761 ttttcaagat agttttatgg taaataagat atacctaata taactaataa aataagaata
    26821 ctatattttt atatataagt ataatattct caccttagca ttaatttatt tcaatatttt
    26881 catatatctt ttattctaaa ttcaatactt ttctaatatc ttctatacct tgataaactt
    26941 cttgtttaga aaaattcata gcttctaatt cttcatcagt tttttccata agcatagtat
    27001 aaaattctat tgctatatac tgcatatttt cactatttac actcttagct ttatcaaata
    27061 aaatttcttc tgcttcgttt acatttccct gaaaaactaa tctttttaaa gttataagta
    27121 taacttcttc ttctgtatta tacactaaat ctttttcttc atattcactg tatttttttc
    27181 ccaataaaag tcttgcaacc ataagtttta tctcattgaa aatcttatcc actatagcca
    27241 tttttacatc tcctataaat aaattttatt ttctttttaa ttatatcaga ctttatcgta
    27301 aaaattatta tatgtaaatg aaataattca aaaataaatt ttaacaataa aaaaaagaag
    27361 gtagcggggg atttccgact accttcaaac actagattgt gattggtttg gtattttatt
    27421 tatacccacc ataagcttta ttaaatcatc taaattgatt tttttagcat ccacatcctc
    27481 catcaaaaac gtcaccacat tcacaaagta ttaataataa tattaagaaa ggtatccatg
    27541 cacataagtc catttcagcc caacaatctt ggaatgctaa gaataagaag aataatatta
    27601 ttatccacca agcacatcca ccaaatccgc cttcaccaaa aaatctatcc aacataatat
    27661 gttacctcct agtcattttg tatgtggagt ttcagctcct aaaatatact atgtttaagg
    27721 ggtaatattt gctaatgatt tttttaaatt tttttagata tttttaaaaa aattattgat
    27781 tcacactcaa tgtcttacca tcactattga taactacctc tccattagaa gtcaaaaatg
    27841 tttttatatt caatctttcc aatattttta aaacaccttc ctctggttct tttttctctg
    27901 aacatgtaat aacagcatat tggggtgaaa tagactctaa aaatgtttca gttaatttgt
    27961 catatcttcc atgatgaggc attttaacaa aatcatattt taaagtattt ccatttataa
    28021 actctgacaa tctttcttcc tctgcatctc ctgcaaataa aaacttatgt gctccatagc
    28081 ttatattagt gattattgaa taatcatttg aactctcgta cttgcttttt gaagccggat
    28141 gtatgtttat ttctgcacta ttgattacaa tattcatatt atcttttagt agcactggtt
    28201 ctatatcagc ttttttaagt gaatcaatat attcatcata ttgcttacta tctttcttat
    28261 aatttgcttg tataatattc tttactttaa cactagataa cacactatct actccaccta
    28321 tatggtcctt atctaaatga gttaaaatta aatagtcaag tgtatttatt cctttttctt
    28381 ttaacctatc cactatttgt tttccatttt tatcttctcc tgtatcaatc attatgactt
    28441 tgttacctat ttcaaccaat atacagtcag actttccagt acttaatata gtagtcttaa
    28501 atgcagtatt ttttgtgcta ctctgaatat tattttgact cacatcattt ttgtcacttt
    28561 ttaaataaga ttcattcgtt gattttatct tactattagt agttatattt gttacaagca
    28621 ataatattac tattatagat aatgtagtaa ctaaaaacag gatatctttt aatactattt
    28681 tcctcatcca aaagctccta taaattttat ttattacata tttatagtat agcaacctta
    28741 actctgtaaa atacacatat aaaaagggca aattttaggc atatttgtgg catgataaaa
    28801 aaatgactgt accaaaacaa ttatctttct aaatttacat cttcaaattc tttaatctta
    28861 tcattagata aaacactctt tttagtagat tgtccatttt ttctatcaaa agtattttta
    28921 gcttttacac ctgataaaaa cttacctgct ccattaatac aaccttcttc acacatcatt
    28981 ccttctataa aattaccttc taatcttccc aatttagcca ttgtcattgt ctttttaatt
    29041 tgtcttggac cagatacttt tataggttca aaatcaaaac taagcccctt ttcagcaata
    29101 tagttctgta ctgatttggc aagtccacca gatgctccaa atccccttcc aaaaatcgaa
    29161 ccatcattta tatcttcatt tgaacatttt gataaatcta tattaaatgc ttcaaataat
    29221 gccattagtt cttcaaaagt aagtacataa tctactgaat cttttaaact tttctctgtt
    29281 gcctcactct ttttagctgt acatggacct ataaatacaa ctttagcatc agaatctatt
    29341 ttttttacta atcttcctgt tgctaccata ggagacactg tagatgatat tctatctttt
    29401 tcatctggga acatcttctc tatatactta aaaaatcccg gacaacatga atttgtcatg
    29461 taattatctc ctgattttat tctttcaata agttcattgc tttcatgaac tgtaactgca
    29521 tctgctccac aagaagcttc tatcatatct acaaatccca gtgattttat agcatttttt
    29581 aactgaccat atgtaatatt actatctatt tgacctgtta tagctggagc tactattgca
    29641 tacatatttt ctttctttgc aagttttttt gcaacaggtg ctatcaaact cttatcagat
    29701 attgctccaa atggacatgc tgacatacat gctccacaat ttatacaatt atcttcatgt
    29761 atcattgctt tcatagtgtt tctattaaaa tccaaagctc ctgttggaca aacgctttta
    29821 caaggtctta caacttctga tatagcatca tattgacatg aacttttgca cattccacaa
    29881 gccttacata aatcatgatt tatatatgct ctcccattta tataagaaat tgccccaaat
    29941 ttacatgctt ccttacatct atgagccaaa caccctctac aaagctctgt aactgtaaat
    30001 tcatttattg gacatctatc acatgctgct tcaactatat atataatttg ctcatctgtg
    30061 tccaaactaa ctgaatctgg atttatatct ccatatttac tatttggagt taaacttaat
    30121 gcaagttgcg ccctttcaag aactacttct ctctctttat aaacacaaca tctatatctc
    30181 gccttttctc ctttaattat ttcatatgga attttttcta tattttcttt tgttaaattt
    30241 tcttcaatag atagtcttgc tactgctgtt aaaacttcat gttttaacct ttttagttgc
    30301 gtttcaaatt caaacataag taatcctccc tataaatcac acctttttgc tatatttcta
    30361 ctattatgta tattgtattt tttatttatt tctataaatt attataacat aggcatatac
    30421 tttgttaagt tatatacaaa atattatata tgtaattttt attttaagtg tatataattt
    30481 ttattttagt tgttcaataa ttaaatatat aaataaaaat agagttgtcc aaaagttaaa
    30541 cctcaactta gaacaactct attaacaata tgtatttttg ttgctttgta ttatctttat
    30601 ttttctaaat ttatattact aaaatctttt atctttgtat ttgctaagac acttttctta
    30661 gttgattgag aattttttct atcaaaagtg gctttaacct ttgcacctga taagaattta
    30721 ccagaaccat ttatacaacc accttcacac atcattcctt ctataaaatt accttctagc
    30781 tttcctaaat tagccatagt catagttttc ttgatttctc ttgaaccaga aatctttaca
    30841 ggttcaaaat taacaccaat acctttttca gcaagataat tttctatagc ttttgtaaga
    30901 ccaccagcag ctccaaaacc tcttccaaaa attgatgcat catctatatc ttcatttgaa
    30961 cacttagcca agtctatatc aaatgcctca aataatgcca ttatttcttc aaaagtaagt
    31021 acataatcaa cagctccttt taattctttc ttagctgcct cactcttttt ggctgtacat
    31081 ggtcctatga atacaacttt agcatctggt tcatgacttt ttataaatct accactagct
    31141 atcataggag acactgtaga agatattttt cctacatgat ttgggtatgt tttttctata
    31201 taaccaacaa atcctggaca acaagaattt gtcataaaag cttctccctt ttccattctt
    31261 tcagcaaatt ctaagctttc atgaactgta actgcatctg ctccacaagc tgcttctaat
    31321 acatcaacaa atcctagtga ttttatagca ttttttattt gaccatatgt aacatttgct
    31381 tcaacttgac ctgttatagc tggagctacc accgcataca ttttctcttt ttgaactaac
    31441 tttctagcta caggagctat caaactctta tcagatattg ctccaaatgg acatgctgac
    31501 atacatgctc cacagtttaa acatttatcc tcatgtatca tagctttcat attttctcta
    31561 tcaaatccta aggcattagt tggacaaaca ctcttacatg gtctaacaac ctctgagatg
    31621 gcatcatatt gacaagcttt tttacacatt ccacaagcct tacataattc atgatttata
    31681 taggccattc ctccgacatg tgttatagct ccaaatttac aagcttcttt acatctatgt
    31741 gctagacatc ctctacaaat atctgttact gtaaattcat ttattggaca actgtcacat
    31801 gcagcttcca aaatatatat aatttgttca tcttcttcta tatccattgt atctaaatct
    31861 atcttatctt gacctggttg taaccccata cttacattta ctctctcaga tattatagct
    31921 ctttctttat aaacacagca tctgtatgta ggtttctcac cttttattat ttcatactga
    31981 atattatcca ttgcttctct ggtaaggtta tcttcttttc caagtctagc tattgcagtt
    32041 aaaacatcat gtcttaattt gtgtatttgt gtttcaaatt gaaacatttt aataccaccc
    32101 ccgtaaatga ttttatacga taccattata acacaatatg tccttttatt aatatataca
    32161 taaaatatta tatgtttaaa ttttatttta tcgaatatat atagtgtttt tttgttttat
    32221 tatataatat tattgatatt tctgaaattt cactattttt atttttactt ttcaatctaa
    32281 tatataatat tttttattat atattttaat tttacttttt acttacatac ctttttgtta
    32341 cattttttga tattaaattt attatctaca tttacatttt cgtcaaattt tacaatactt
    32401 ctcactgtat aatttaacaa tttttattaa attctaaaag taattaattt ttttaaaaat
    32461 tttatttgct tttatttaaa atttatgtta tattaataga acagacttat ttttttagtt
    32521 tgtatttttt aataatgcgg aggttttctt ataatgaaaa acggaatagt aaaatggttt
    32581 aacaatgaaa aaggatttgg attcatatct gtagagggag aagatgatgt tttcgtacat
    32641 ttctcagcta tacaaaatga tggatacaaa actttagaag aaggcgaaaa ggttagcttt
    32701 gatataactc aaggtaatag aggacctcaa gctgaaaacg taaatagaat ataattattt
    32761 aatttaaata tatatatttt agaaaaggag ctatcgaggg ctcttttttg ttgtttatta
    32821 tatttatttt taattacaaa aataagaagt tactttagaa aagcgtcaaa cttaaaataa
    32881 cttcttatat tataatatat actatttata taaaatactc tatttaattt tatcagatat
    32941 tattaagcat aactctctta agattttaca agctataact gtcgatacac ctgttgtatc
    33001 gtaatcaggg cttaactcta caatgtcaca accaactata tttatattag agttttttat
    33061 aatcttaaaa atctcttgaa actctctata atttacacca ccaggttctg gtgtacctgt
    33121 tcctggaaac acagatgcat ccaatacatc taaatctata gttagataaa tattctttcc
    33181 atttagcata ttaactatat tttcaaacgt atctattcct cctatttcca tgtatgtgtg
    33241 tttttcttct gtagcaaatt taaattcttc ttttgtccca gaccttatac caaattgaaa
    33301 tattttatta tcacctacaa tatcccatat tcttttaatt actgttgcat gagaattttt
    33361 actattatta tattcttccc tcaaatcagt atgggcatca aaatgaatta catatatatc
    33421 attatacttt tcatgtactg ctttaaaggc tggtaatgta actaaatgct ctcctccaat
    33481 cataaagggt acctttgaat ctctaacaat cttatatgtc tcttgataga tttcttttaa
    33541 gacttgttct gtacttccaa cactaatttc taaatctcca taatcacata tattataatc
    33601 ctctaaatcc aaatctaaaa aaggactata tgtctcaaga ccgtaaaatt cttttctcat
    33661 agagctactt gcaaatctag ccccaggtct gttagaagta gttccatcaa atccaacacc
    33721 aaatactata agattagatt cttcataatt tttgttcata ctcataaaag tgttcatatg
    33781 atagaaatta ttcttcatcc agcatctcct tcacgtattg aggtaacata aacgaaccta
    33841 aatgtatatc actattataa tatttagttt ttaaacttaa tttctcccat ccatttctat
    33901 cttgattttt tactggatta agtttttttg aagcaaatcc aaacaaccag tgaccagatg
    33961 gatatgttgg tatatgtgct tgataaactt ctgatattgg aaatatctgt tttaactttt
    34021 tattagctct tttcatctct ttagcattaa agtcaaaata cggactttca ctttgattta
    34081 ctaaaattcc atcatcagtc agtattctat aacaatcctt ataaaaatca gttgagaaaa
    34141 gcccttcacc tggtcctatt gggtcagttg aatctactat tatcaggtca tatgatttat
    34201 catgtgcaca cttaacaaaa ttaacaccat cttcaaaata taaactcact cttttatcat
    34261 ctaatttaca tgagcatata tccatatact ctttagatac atctacaacc attttatcta
    34321 tttcaaccat gtcaatcttt tctatttgag gataacggct taattctctt actgtacctc
    34381 catcacctcc acctatgact aatactttct ttatgtttaa atttgtagcc ataggaacat
    34441 gagttatcat ctcatggtat ataaattcat ctttatatgt taccatcatt aatccatcta
    34501 ttgttagaaa ttttccaaat tcatcactat caaacacatc tatcctttga aattgagact
    34561 ttccttcaaa tagatgttta tttactttta tagaaaatct tacattttct gtccattctt
    34621 ctgtatacca aagttccata taataatcct cactttctct tgtatgtttt atactgcttc
    34681 tggtttatga gtaatcttac ctaaatcttt ttttgaatat tttttaattt ttgtagttaa
    34741 gcctcttgga atttctgtag actcgcttct ttcagacttt aaaagttgct ctaataattc
    34801 aaaacttttc catgggtcta tatcaccaca agtaaaaaaa tctgctgctg cataaccata
    34861 ttcaggccat gtatgtattg tcaaatgaga ttcagcaatt ataacagctc ctgaaacccc
    34921 ccaaggatta aaatggtgga atacagaatc cacaattgtc gcttttgcat ttaatgctga
    34981 atcattcata aaattttcta taagacgtgg gtctttaagt acgttttcat cacaattata
    35041 gtattctact agtatatgtc ttcctagtgt ttcaaatttc atttcaaccc caactccttt
    35101 atacttttaa taagttctat ttgataaact ctacttaaca aacacttgcc cttgcaaaat
    35161 aaagtaattt attttattac tagtattcta tctaagtttt tatcttgtac atctgtaaga
    35221 tatgcattgc tattttttaa gaaaataata tactccataa tttcttctgt tatcaattct
    35281 cctggagcaa taatcggtat acctggtgga tatgccatta ttgattctcc acaaattcta
    35341 tctatacatg aattgatttc tacactttcc tttggtgcat aaaaagcttc tcttggatta
    35401 agtttaataa ttggatttat ttgaaccata ttaaattcat ttaatgttga ttcttttcta
    35461 taaatctttg caattataga aagtgccttt actaatctat ctatatctga tttatttgtt
    35521 ccaatggaca caagtgccag tatattatat gaatctccca attctacttg aattgaaaaa
    35581 tttttatata ataaatcgta tacttcaaat ccagtcaaat ttaattcttt tacatttata
    35641 cacaattttg tttcatctat aaatttaaca cctttttgtt tcaatatttc tgtagataaa
    35701 acttttattc catcaatttt gttcaattta gattttgcat acctagatag atttaatgct
    35761 tttgacaatt gcttttcacc attctcaact agattaactc tagcaccatc tatacttgcc
    35821 ataagcaaat aagatgctga tgttgattgt agcatattga ttgattgaag aaccttttca
    35881 aaacttacat tatctctatt caataagagt gctgaagatt gtgtcaatgc tcctccagtt
    35941 ttatgtatac ttacagctac catgtcagct cccaaactta ttgcagaagg aggtaaatct
    36001 aaatgaaatg gaaaatgtgc accatgagct tcatcaacta acactaaaac attattttta
    36061 tggcatagtt ctataatact ctcaaggtct gcacaaactc catagtaagt tggattaagg
    36121 aaaaataatg cttttatatt acaatctttt tctatctctg ttctaacttt ttcaagagta
    36181 atatttaaac ttatacctag tttttcatca aattctggtt gtataaatat tggtattcct
    36241 ccacaaagta ttaacgcatt tattactgat ttatgtatgt ttcttggaag taatactttt
    36301 tcacctggtt ttataacact caaaatcatt gcatgtattg cttgagttgt gccattcgtt
    36361 ataaagaatg cctcatcagc catatatgct tgtgctaaca aatcttgtgc attttttata
    36421 atcccatttg gcgcagatac attatccata gttggtgatg aatttatatc cattttcatg
    36481 agactttcac ctagatattt atttaatata gctacacctc tattttttac atgtccaggc
    36541 acatcaaaac aagctatatc tttctctgag tattccttta acgactctaa taatggagca
    36601 cactcatagc ttaattcaac tgcatttgca aactcgctat ccatgatttc aaattcatct
    36661 cctctctata ttcaaatatt tttaatattt attatttatt atttctattt tttattttta
    36721 cttttattaa actcatgata tttattatat taacatccca gcatttttac aagtgttttt
    36781 ttgaagttac tcaaaaacat atacattagc tatatcaata tttataaact ttttaatttt
    36841 ttgttgttta tattaatttt tttaaaactt agtatttata aactttctta ttttttatta
    36901 ttttggtttt tttacttttt tgagttttag taagcttttg agtttactat ttttaattta
    36961 taagtatttt attactaaac ttttatatta ttcttatttc acatatcaaa att
//
LOCUS       DAEPID010000037        36498 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.037, whole genome shotgun sequence.
ACCESSION   DAEPID010000037 DAEPID010000000
VERSION     DAEPID010000037.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 36498)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 36498)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..36498
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.037"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            27..101
                     /locus_tag="KR257_002031"
     tRNA            27..101
                     /locus_tag="KR257_002031"
                     /product="tRNA-Thr"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:59..61,aa:Thr,seq:tgt)
     gene            116..200
                     /locus_tag="KR257_002032"
     tRNA            116..200
                     /locus_tag="KR257_002032"
                     /product="tRNA-Tyr"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:150..152,aa:Tyr,seq:gta)
     gene            210..293
                     /locus_tag="KR257_002033"
     tRNA            210..293
                     /locus_tag="KR257_002033"
                     /product="tRNA-Leu"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:244..246,aa:Leu,seq:tag)
     gene            317..391
                     /locus_tag="KR257_002034"
     tRNA            317..391
                     /locus_tag="KR257_002034"
                     /product="tRNA-Gly"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:349..351,aa:Gly,seq:gcc)
     gene            416..492
                     /locus_tag="KR257_002035"
     tRNA            416..492
                     /locus_tag="KR257_002035"
                     /product="tRNA-Arg"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:450..452,aa:Arg,seq:tct)
     gene            502..577
                     /locus_tag="KR257_002036"
     tRNA            502..577
                     /locus_tag="KR257_002036"
                     /product="tRNA-Gln"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:535..537,aa:Gln,seq:ttg)
     gene            586..661
                     /locus_tag="KR257_002037"
     tRNA            586..661
                     /locus_tag="KR257_002037"
                     /product="tRNA-Lys"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:619..621,aa:Lys,seq:ttt)
     gene            664..752
                     /locus_tag="KR257_002038"
     tRNA            664..752
                     /locus_tag="KR257_002038"
                     /product="tRNA-Ser"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:698..700,aa:Ser,seq:tga)
     gene            756..831
                     /locus_tag="KR257_002039"
     tRNA            756..831
                     /locus_tag="KR257_002039"
                     /product="tRNA-Phe"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:789..791,aa:Phe,seq:gaa)
     gene            838..911
                     /locus_tag="KR257_002040"
     tRNA            838..911
                     /locus_tag="KR257_002040"
                     /product="tRNA-Met"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:872..874,aa:Met,seq:cat)
     gene            926..1002
                     /locus_tag="KR257_002041"
     tRNA            926..1002
                     /locus_tag="KR257_002041"
                     /product="tRNA-Ile"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:960..962,aa:Ile,seq:cat)
     gene            1020..1096
                     /locus_tag="KR257_002042"
     tRNA            1020..1096
                     /locus_tag="KR257_002042"
                     /product="tRNA-His"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:1054..1056,aa:His,seq:gtg)
     gene            1105..1180
                     /locus_tag="KR257_002043"
     tRNA            1105..1180
                     /locus_tag="KR257_002043"
                     /product="tRNA-Lys"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:1138..1140,aa:Lys,seq:ttt)
     gene            1188..1261
                     /locus_tag="KR257_002044"
     tRNA            1188..1261
                     /locus_tag="KR257_002044"
                     /product="tRNA-Cys"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:1220..1222,aa:Cys,seq:gca)
     gene            1269..1345
                     /locus_tag="KR257_002045"
     tRNA            1269..1345
                     /locus_tag="KR257_002045"
                     /product="tRNA-Arg"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:1303..1305,aa:Arg,seq:acg)
     gene            1358..1433
                     /locus_tag="KR257_002046"
     tRNA            1358..1433
                     /locus_tag="KR257_002046"
                     /product="tRNA-Val"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:1391..1393,aa:Val,seq:tac)
     gene            1509..1922
                     /locus_tag="KR257_002047"
     CDS             1509..1922
                     /locus_tag="KR257_002047"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009887782.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0030733.1"
                     /translation="MYIVIGNEIVDSEELKIIIDKNSEFKVEKDLSKSTKREDVIAYQ
                     LSIDLNYLDSLINEQCNLASLSDEEKFDEYMTLSDELALDLEELMPKYTIINARAYKL
                     DEVDGIVKIILAVAYADLGHLKLSDVVKRLSRQVD"
     gene            2231..5662
                     /locus_tag="KR257_002048"
     CDS             2231..5662
                     /locus_tag="KR257_002048"
                     /EC_number="6.4.1.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425597.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pyruvate carboxylase"
                     /protein_id="HBH0030734.1"
                     /translation="MLKKFNKILVANRGEIAIRIFRACSELGIKSVGIYSKEDKYGLF
                     RTKADESYLIGEGKGPIDAYLDMDGIIDLAKRKKVDAIHPGYGFLAENAEFARKCEEN
                     GITFIGPSSKVMNMMGDKINSKKIAKEVNVQTIPGVEKAIRSTEEAKEVANKIGYPVM
                     IKASNGGGGRGMRIVHREEDLELEYETACSESRKAFGEDIIFIEKYIADPKHIEVQIL
                     GDNYGNIVHLYERDCSVQRRHQKIIEYAPAFSLDDKVRKEICEDAVKLSKHVGYSNAG
                     TLEFLVDANGGHYFIEMNTRVQVEHTVTEMVTGIDIVQSQILIAQGYSLDSEEINIKS
                     QDDVEIRGYSIQCRITTEDPKNKFMPDTGKIQVYRTGSGFGIRLDGGNGFTGANISPH
                     YDSLLVKTISWDRTFQGAINKTIRSIKELRVRGVKTNVGFLVNVLNNPIFSNGKCSTK
                     FIDENPDLFEITESKDRGTKLLQFIGDVIVNDNACKEKPLFDALHDPRMDKDGSKSEG
                     SKILFDKLGKSAYIEKIKNDKKLLLTDTTMRDAHQSLLATRIRTYDLLKAAKPTEKYQ
                     KDLFSLEMWGGATYDVAYRFLKESPWRRLQKLREEIPSIMFQMLLRASNGVGYKNYPD
                     NVIEEFTKESARQGIDVFRIFDSLNWVENMKPSINTALETGKIVEATMCYTGDILDKT
                     KTKYNLEYYIKMAQELESLGADIIAIKDMSGLLKPYSAYTLVKELKKNVKAPIHLHTH
                     DTSGNGVATCLMASEAGVDIIDAALESMAGLTSQPSLNAIVEALKNTERDTGIDLFGY
                     DELGKYYKDLRKVYNKFESDLTNSCAEIYNFEIPGGQYTNLKPQADSLGLVNRFDEVK
                     EKYKEANEVVGDIIKVTPSSKVVGDLAIFMTKNKLDKDNIIEEGKNLSFPDSVVDYCK
                     GMIGQPEGGIPKDLQEVVLKGEEAITVRPGSLLPAEDFDEIAKYLNEKYDINANIRNV
                     ISYALYPKVYEDYIKHLQHYNDISKLESDVFFYGLNKNEECEVEIEEGKVLTIRLVEI
                     GEVKENGFRTIGFELNGMVREVEIKDKNFSGKINNVEKADMNDPLQIGASIPGKVIKI
                     MVKEEDEVKANQPLIVIEAMKMETIIVAKTDGVIKSIKVKEDDMVEDKQLLMIMK"
     gene            5904..7832
                     /locus_tag="KR257_002049"
     CDS             5904..7832
                     /locus_tag="KR257_002049"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009904742.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="elongation factor G"
                     /protein_id="HBH0030735.1"
                     /translation="MKVYDSKMLRNVAVLGHSGCGKTNLIETIAYTANTNKIPKLTDK
                     VNMTYSMGLIPIEYNDYKFNLLDTPGYFDFSGDVVSSLRASDAAIIVIDATAPIQVGT
                     EKSLELTESIPKIMFINKIDNEKARYKDAIAMLREKYNNKIVPMISPIYKDKNFVKLH
                     NVFENIDDLEGEFKEQAMSVKEALMELIAETDDQILDKYFNGEELTTEEIQKGIIIGI
                     QRGDIIPVICGSTINNIGTKEILDTISSYLEPIFTEESKPFRGLVFKTMVDPFVGKMS
                     YIKITEGVLSKDKDVFNINKNVKEKIANIYTLRNSELVEIEKAKAGDIVVITKVNSLK
                     TGDTISADKDAEALEKIDFPKPQIYYAVTPKNKGDEEKVASVLNKLVEEDPTLHWYRN
                     TETKQALLGGQGELHIKTIKNKMKDKFGVDVELNDLKVPYRETIKGTADVQGKHKKQS
                     GGHGQYGDVKIRFERCESDFEFTEEIFGGSVPKQYIPAVEKGLKDSMQKGILAGYPVT
                     NIKATLYDGSYHDVDSSEMAFKMAASAAFKKGMEEAHPILLEPIMKLKITVPEEYMGD
                     VMGDINKRRGKIFGMEPDDKGKQIIFAEAPQAETFKYAIDLRAMTQGRGYFEMELERY
                     GEVPSQFAEKIIGLATAK"
     gene            8285..8749
                     /locus_tag="KR257_002050"
     CDS             8285..8749
                     /locus_tag="KR257_002050"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425587.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CtsR family transcriptional regulator"
                     /protein_id="HBH0030736.1"
                     /translation="MATMTDIIEKFIKDLMEEDNSIQIQRNELANLFSCAPSQINYVL
                     TTRFTIDRGYYIESKKGGGGYVQIEKIRKSKDGHIRELLNEKIGSQISYKKAKELLEG
                     LKESDLINERELKLILYAIDDKSLCMPIYELKEKVRSNILKNIIIGLFSIEE"
     gene            8756..9250
                     /locus_tag="KR257_002051"
     CDS             8756..9250
                     /locus_tag="KR257_002051"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421255.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="UvrB/UvrC motif-containing protein"
                     /protein_id="HBH0030737.1"
                     /translation="MLCQKCNKNKASVYYNKIVNGEKTEMYLCSECAKENTEMNFNLD
                     MPFSMMDIFSNLGFQPKKELEEKLVCPKCNTTYSEFKNNGRFGCSECYNAFSSQVNPM
                     LQNIHGHIEHTGKAPKKSFYKISVENEIKELKEDLDRAIKNEEYELAAQFRDKIKYLK
                     GSID"
     gene            9266..10291
                     /locus_tag="KR257_002052"
     CDS             9266..10291
                     /locus_tag="KR257_002052"
                     /EC_number="2.7.14.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421251.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="protein arginine kinase"
                     /protein_id="HBH0030738.1"
                     /translation="MKENIVMKSRVRLARNLNNYPFPNKLDKECAMEIIEKVKNAFIN
                     SNLEQKEEFDFYKIEDLDQSKKMLMVEEHIISPDLAENDKSAVIVKKDKTISIMINEE
                     DHIRIQTICDDLNLEYAYSVANEIDDLLESSLEYAFNTKLGYLTSCPTNTGTGMRASV
                     MMHLPALSQLGYMDELYKISSQIGIAIRGIYGERTEALGNIYQISNQLTLGRTESNII
                     ENVSGLTKDAISKEIKAREILQKKLGIKLEDKIFRSIGTLENSRVMSSAEAMSHLSNI
                     KMGIEMNYIDKLDLRAIEQLMIGIQPAHQSIMYKSDDVENRDINRATYIRETLEKLRG
                     GMNCELQ"
     gene            10278..12725
                     /locus_tag="KR257_002053"
     CDS             10278..12725
                     /locus_tag="KR257_002053"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421249.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-dependent Clp protease ATP-binding subunit"
                     /protein_id="HBH0030739.1"
                     /translation="MNFNRFTQRAKKAIDLAFESAKSLGHNIVGSEHILLGLLREEEG
                     IAAKVLSKVGFTEAYLEGKIVDMEGKGEEISEDIVLSPRSKQILELSGMFANKLKTNY
                     IGTEHILLAIIQEGEGIANKILNYAGVNDRTLAQLTIDMMGISDKNQYKAENSYTGNQ
                     NQAESKVLDKYGRNLTLYAKQNKIDPVIGREKEIQRVIQILSRRTKNNPVLIGDPGVG
                     KTAIAEGLATNIALGNVPETLKNKTLYSLEMGSLLAGAKYRGEFEERIKEVVDEVVKN
                     GNIILFIDEMHTIIGAGSTGEGSIDASNILKPALARGEIQVIGATTIDEYRKHVEKDS
                     ALERRFQPVMVDEPTKEDSIKILEGLRDKYEAHHKVKITDDAIKAAVELSTRYISDRY
                     LPDKAIDLIDEAASKVRLKENTPPSEIKKLELEIENIDKEKEEAVRCQDFEKAAKIRD
                     EQGLLKKQLEDVRERWNKSSKHSDLVDGEVIAEVVGLWTGIPVNKILEEEADRLLRLE
                     EILHNRVIGQEQAVKSISKAIRRSRAGLKDPNRPIGSFLFLGPTGVGKTELSKALAEV
                     QFGDENQIIRIDMSEYMEKHAVSRMIGSPPGYVGHDEGGQLTEKVRRNPYSVILFDEI
                     EKAHPDVFNILLQILDDGRLTDSKGRTVDFKNTIVIMTSNVGASTIGRQKTLGFSIAK
                     GDEEEKSQYEKMKENIMGELKQRFRPEFLNRIDDIIVFHSLNENHISKIVLLMAAKLQ
                     ERLKEMDIKLEMSDEAVKLISKSGFDLEYGARPLKRALQKELEDELSEAILKGNVKKG
                     SNVVAKVKDEKIVFETK"
     gene            12905..14278
                     /gene="radA"
                     /locus_tag="KR257_002054"
     CDS             12905..14278
                     /gene="radA"
                     /locus_tag="KR257_002054"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421247.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA repair protein RadA"
                     /protein_id="HBH0030740.1"
                     /translation="MAKIKTKYVCQSCGYETAKWLGKCPECTKWNTFVEEIDQKSTKK
                     EVFIIDKSSSKPVSINSIESKEEERFTTDINELDRVLGGGIVKGSLVLVGGDPGIGKS
                     TLLIQVSSNVANLGKTVLYITGEESESQIKMRAKRLGINSENLYIFAENNLSIIESYL
                     ESVNPELIILDSIQTVFSPEISSAPGTVSQIKEGTSKFMKISKKMGISTFIVGHVTKE
                     GSLAGPKLLEHMVDTVLYFEGERYNTYRLVRAVKNRFGSTNELGVFEMRDLGLVELDN
                     PSKILISEKPKDVAGSVIISTVEGTRPMLLELQALVSPTSFGIPKRTSTGVDYNRVGM
                     LLAVLEKRVGLQIQNQDVYINIVGGIKINEPSIDLGIAISVASSFRNIPIDEDIAVTG
                     EVGLTGEVRAVSFIEKRIAECKKLGFKKIVVPRSNYDVVKETKGIEIWPVDNLRQAIN
                     IVLGRNQ"
     gene            14281..15351
                     /gene="disA"
                     /locus_tag="KR257_002055"
     CDS             14281..15351
                     /gene="disA"
                     /locus_tag="KR257_002055"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004453975.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA integrity scanning protein DisA"
                     /protein_id="HBH0030741.1"
                     /translation="MENFLDNKNMLYALKMISPGTPLRLGLNNVLRAKTGGLIVIATN
                     EDVMKIVDGGFAINAEYSPSYLYELAKMDGAIVLSGDVKKILFANAQLIPDYFIETSE
                     TGTRHRTAERVAKQTGAIVIGISQRRNVITVYRGNEKYVVEDISKIFTKANQAIQTLE
                     KYKTVLDQAVTNLNALEFNDLVTIYDVALVMQKMEMVMRVTSIIEKYVIELGDEGTLV
                     SMQLEELMGTTRIDQKLIFKDYNKENTEIKELMKKVKNLNSEELIELVNMAKLLGYSG
                     FSESMDMPIKTRGYRILSKIHRLPTAIIENLVNYFENFQQILDASIEELDEVEGIGEI
                     RATYIKNGLIKMKQLVLLDRHI"
     gene            15440..16534
                     /locus_tag="KR257_002056"
     CDS             15440..16534
                     /locus_tag="KR257_002056"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421243.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PIN/TRAM domain-containing protein"
                     /protein_id="HBH0030742.1"
                     /translation="MIRKVTRILFILLGFTIGITTYLTLMKDFEILTFGKETYGYIAA
                     VVAGIIIAILGYLIEPWVVNKVKEIAKIVDKELSKYPQTDILLGSMGLIVGFVIAYLL
                     SGLVNRIPIVGGILSLLLYLFLGYLGMKVALKSKNDLFNIGKLGRLANPIKDKDKDKE
                     NKKEVKAIPPKVLDTSVIIDGRIADICKTGFIEGKLIIPAFVLEELRHIADSSDDLKR
                     VRGRRGLDILNIIQKELNIEVEISERDFDDIAEVDSKLLKLAQVLNGKVVTNDYNLNK
                     VAQFQGVEVLNINELANAIKPVAIPGEDMVVQVVKEGKEAQQGVAYLDDGTMIVVDGG
                     RKYMNETIKVLVTSVLQTPAGRMIFAKPKN"
     gene            16663..18840
                     /locus_tag="KR257_002057"
     CDS             16663..18840
                     /locus_tag="KR257_002057"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860624.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0030743.1"
                     /translation="MRKKIISFLATFIIILTSASQYSFADDISTRGKVIFIDMNRTSM
                     SNMLRIKSLREELDNRGYIGLMNIRGDKGSDDRRSYASMGAGGRANVANEEDINFESS
                     SKDRNIVFESATGKSAKGINNLTINKSINENLNFGEYGSVLGSLGQSLSDNGLKASVL
                     GNSDIIENGQLIKNRNLCLTAMDEYGRIPNGNVDTINKKDLSMPYGISTDYDKLIVET
                     KETYKNNDVIFVELGDTYRLDLYKPNLNEKTYESMKDNIEKNIDIYLKNIFSMVEEND
                     TIYIASAFPSDLDYKNKRRLSPIIKLNGEGKGILSSSTTRREGIVTNLDVGVEILDNF
                     NIKNQNMVGRKYELINRDDNKEFLMDEYQKIVSISSIRSTILNGFVSIVFLSWIVAMI
                     AILFRKHISKNYKETTFFILKELLKIGIVMPLSFMITPIMNFKTPLAISLGIIIITLT
                     IYLISKVLIKNDLKNMLFFTGLTIVIMVIDAGFGSYLMKSNVMSYDCIIGARYYGVGN
                     EYQGVAIGSAIFTFAILLTYKNIPKWYIIVFSLVILITSASPIMGANVGSAISECVAF
                     LLFILLIYNVKIDFKKIVLLGIAVVFVLGVFVAIDMILGSNSHLGMFVKEIYFNGPGE
                     IIQTFSRKIEMNLKLAQTSAWVNILLTGIGVILVLMINQIRYFKQLMDEYPIVFKGFI
                     ASIAGCLVTLLVNDSGIVSSATAFIYVIVPMITLSINLTALKE"
     gene            complement(19026..19871)
                     /locus_tag="KR257_002058"
     CDS             complement(19026..19871)
                     /locus_tag="KR257_002058"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425570.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="HBH0030744.1"
                     /translation="MNRNNFSHEIIEPIDNLDVNFKLFDDSGSYVANHWHNSLEIIYI
                     TSGDLQINMEGYTYNLKANECMFINSGIIHSTRCIYQNTSILLQVPLSFLNKYIPDFK
                     NCYFDFKVNANDNNYKKNSSKVKLILENMREIKLSSPPAANLLFTSLLFELLFELYTN
                     FKISVGNKNMKKTVLDLSKFEPVLEYTKINYKMPISINKIAKVAHLQPEYFCRKFKQY
                     MGQTYLEYLNDVRISHIYKDLINTNDTLCSILEAHGFTNTKLFYRIFKEKFKCTPKHI
                     RKKST"
     gene            20088..21254
                     /locus_tag="KR257_002059"
     CDS             20088..21254
                     /locus_tag="KR257_002059"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009887803.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cellulase family glycosylhydrolase"
                     /protein_id="HBH0030745.1"
                     /translation="MYIKGVNLGGWLVLEKWMTSSLFEGTEAEDEYYLPRQLSREAYE
                     SRIKTHRSEYITERDFATIKSMGFNSVRIPVPYFIFGDCEPFIGCVKELDKAFAWADK
                     YGLSILIDLHTVPGSQNGFDNGGISGICSWSQNPEYVAFTLNVLERLAKRYGMRHELY
                     GIQILNEPITERMWNIMNVPNRFKAVDKEMARGSKPNSLEFLRDFYIKAYRVMRPYMR
                     EENVIVFHDAFELKAWKDFMREEEFKNVVLDTHQYLMLAEADGCEQSIDSYLKYIREN
                     YAKDILQMQKYFPVICGEWSLFNSYVCGIDTNGGQSPLNGIESNIDKLSKDDKRELYR
                     KIAKAQLDAWRNGSGHYYWNYKLLLDTVNEEGWIGWDSWDLGKCVAQEWYPIEY"
     gene            21276..22922
                     /locus_tag="KR257_002060"
     CDS             21276..22922
                     /locus_tag="KR257_002060"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004453968.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycoside hydrolase family 43 protein"
                     /protein_id="HBH0030746.1"
                     /translation="MIKNPILPGFNPDPCICRKGDDYYLVVSSFEWFPGIPVYHSKDL
                     KNWELYTHILTDETKIDLKKLPSSKGIWAPCLTYCEEEDLFYIVYGIMNSMNARYFDV
                     DNYLITSKDIKGEWSEPVYLHSSGFDASIFHDDDGKKWIASLDWETREGYEKPGVICL
                     VEYCTKKKEIVGYPKRIWSGGTDRGCIEAPHITKRGDYYYIMCAEGGTGYGHSVTMGR
                     AKNIWGPYEKDSMNPIVTSIPGDFYERHDPDHLKPKYYNPESKLQKSGHGSYIETTSG
                     EVYLVHLTSRPFVPELRCTLGRETAIQKMKWTKDNWLRMEDESNLAKEYVSESKLEEH
                     LVSSIPSFDDFDSNELGLQYYAPRISPLSFADVKSRPGYVRIRGQESRTSLNKVSILA
                     RKLTSVYARITTKMEFYPEVHQHSAGLIMYYDNMNYINLRKYYSETLGQSALSIIHLE
                     NGEKTEFLNTRIPIKDIPIYLRLYIQGRKSYFEWSYDEKNYQRIGKVFDTTKFSDEYC
                     KYGEFTGTFIGLTCADRVKHKHYADFDFFEYIVDESKDVD"
     gene            23019..24392
                     /locus_tag="KR257_002061"
     CDS             23019..24392
                     /locus_tag="KR257_002061"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729261.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MFS transporter"
                     /protein_id="HBH0030747.1"
                     /translation="MNTEVNVKATTIRYEKISFFERISYGCGDLGCNIIYSAMSAFLL
                     FYYTNYADVSAAAVGSIMLVSRILDGFSDLTMGIIVDRTKSKYGKARPWILRMAIPFA
                     IAAVLLFSVPSNLGITSKLIYIFITYNLVSTVIYTAINVPYATLNSLITQNQYERGVL
                     SIFRMILATCDTLLINGLTLPLVEYFGNNLSAWTKTFFVFGIASIMVFFITFTGTKER
                     VKAVKQDRNEVIPFKIGIKSLFRNKYWIQITLCLVCIFIVFAINGGSSVYYAKFILGD
                     EKLFGPINMVSNISQIIAMFMVAPFIKKFGKRNVLIVGSIILISSNVMFIIVGQNHIG
                     VIFASAIKGIGSAGIASTMFAIVSDTIEYGEWKTGYRTEGLINSASSFGFKVGNGLGS
                     AILGAVLSIGGYVGTSATQSDLAIVSIKVCFIYLPIFITILQIIIMSFYKLDKEYSTI
                     LNELNTK"
     gene            24837..25790
                     /locus_tag="KR257_002062"
     CDS             24837..25790
                     /locus_tag="KR257_002062"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009904745.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sugar-binding transcriptional regulator"
                     /protein_id="HBH0030748.1"
                     /translation="MKKIGDLRLMMKCCSLYYEDNLNQQEIANQLGISRPTISRILKE
                     AFEQGIVKIQIVDVLKNDYQKIERSLERKYKLKEVIVVDDKQDALTQKQELARAVSEY
                     LTRVVKENDIIGVSIGTTLKEIPRYVEKSNCKNVTFIPLLGGIGDNEIDIHANQIAVS
                     LARAFGGDFKLLHAPAVMSDLSTKEKLCKDEKIKEVLDLIDKTTIAIVGIGNPMSLNS
                     TIMASGYMNEADIEDLKKYNSIGAICLQAFDKEGKTSILEFNQRVLGVKLEDLKKIKR
                     TIGVASGDEKIEAIKASLKAKFINSLAINHSLALKLLEDCD"
     gene            25828..26790
                     /locus_tag="KR257_002063"
     CDS             25828..26790
                     /locus_tag="KR257_002063"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009887810.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="thiamine pyrophosphate-dependent dehydrogenase
                     E1 component subunit alpha"
                     /protein_id="HBH0030749.1"
                     /translation="MSISKETLLEMYKRMNQARKFEEKVSWFFARGMVHGTTHLSVGQ
                     EASSVAAVMALEKGDLVSLTHRGHSQFIGMGIDLNKMMAELMGKETGFCKGKGGSMHI
                     ADIESGNLGANGVVGGGLTIAPGAALTQQYKKTGKIVLCSFGDGASNEGTFHEGINLS
                     SIWKLPIIFYCENNLYGMSTSIKRHMNIESIATRAASYGIEGISIDGYNPIEVYETVQ
                     KAAEKCRRGEGPVLIESRTYRWLGHSKSDANVYRTKEEIESWKAKDPIEFLKNYLIEN
                     NLSNEDELDKIQEFAKQSIEDAVEFAQNSPNPKIESLLEDVYAD"
     gene            26815..27801
                     /locus_tag="KR257_002064"
     CDS             26815..27801
                     /locus_tag="KR257_002064"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425542.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha-ketoacid dehydrogenase subunit beta"
                     /protein_id="HBH0030750.1"
                     /translation="MSTRELTYAQAIKEAMSEEMRRDENVIFMGEDIGIYGGAFGVSV
                     GMIDEFGPERVRDTPISEAAIAGAAAGAAATGLRPIMEVMFMDFVTISMDAIVNQAAK
                     MRYMFGGKAQVPMVVRCPGGSGTGSAEQHSQSLEAWFCHVPGVKVVAPSTPADAKGLL
                     KAAIRDNNPVIFVENKLLYRKKGFVPEDDYVIEIGKADIKREGTDVTVITYGRMLQSV
                     EEAAETLSKENINVEIIDLRTLYPLDKETIVKSVCKTGRVLICHEAAKTGGLGGEISA
                     LITESESFDYLDAPVKRICGKDVPIPYNPELEKAVVPRVDEIEEAIKSLIVR"
     gene            27814..28860
                     /locus_tag="KR257_002065"
     CDS             27814..28860
                     /locus_tag="KR257_002065"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895167.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="2-oxo acid dehydrogenase subunit E2"
                     /protein_id="HBH0030751.1"
                     /translation="MVANKIKATPAARSQARKDNIKLDRLIGSGENGRIHLVDVLNYL
                     KDNKANTTPLARRIAEDLNIDLETIVGTGYNGKIRKCDVEKLTGKETIVSTNTSKSSE
                     KKELKIENENSRMFNTVEGIFEKPNPMRATVAKRMSESYFSAPVFTFNIEVDATELKV
                     LRAKLIDTVKESTGVKLTMTDLIVMAVSKILPNHQALNSAWTDEGIFRYKDVNIAIAV
                     GLDEGLYVPVVKNANKKSLKEIAKESKELAEKVKTGKLMPADQEGNTFTISNVGMYGI
                     TTFTPIINMPSSAILGVGATQDKFVPVNGEAKIKPIMNLSLTSDHRVIDGTVAAKFLK
                     DLKELLENPLSMLV"
     gene            29027..30757
                     /gene="lpdA"
                     /locus_tag="KR257_002066"
     CDS             29027..30757
                     /gene="lpdA"
                     /locus_tag="KR257_002066"
                     /EC_number="1.8.1.4"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860626.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dihydrolipoyl dehydrogenase"
                     /protein_id="HBH0030752.1"
                     /translation="MSVEVIMPKAGVAMEEGTIVSWLKQEGEEVKIGEPILEITTDKV
                     NMEIESEGEGTLAVIIHKEEGEVLPVFTVIGVIAEKGENQEEVKAKYLSGNVSKEDIV
                     EENQNIEFKEEKINKKECNHDYDVVVIGGGPGGYLSALKAALLGGRVALVEENILGGT
                     CLNRGCIPTKTYIKTAEILEEIDQLSKRGVKVTVDKEQDIKKAIKYKNRVVKKLTAGV
                     GGLLKSRDVDVFNLKASVKEEHKVILSDGKVLDTENIIIATGSKVRILPIKGIESNLI
                     ITSTEALDLETVPEELVIIGGGVIGCEFAEIFNSRGSKVTIVEMEDRVIPRMDKELSE
                     SLKYSLSKKGINVLTKKKVSEFKEEGNNILVCIEGEEPIKADLCLYAIGREANLSGIE
                     DLDIKIDKGSIVVNSKMETSIPSIYAVGDVTGGVMLAHAAFKMGEVAASNALGVNKEV
                     DLGALPSCVYTIPEVASVGITEEDARKKYNVKVGKFNFAGNGRALASGQEQGYVKVVA
                     DAKYGEILGIHMFGCGVAELINHAASFKALEIPTDEASELIFGHPCTSEALMEALADV
                     NGECLHLPKK"
     gene            31175..34123
                     /locus_tag="KR257_002067"
     CDS             31175..34123
                     /locus_tag="KR257_002067"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009887817.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sigma 54-interacting transcriptional regulator"
                     /protein_id="HBH0030753.1"
                     /translation="MRQRIKNLIENEDKKNPLTDEAISSRLNIRREDVTFLRNELKIE
                     DSRQRRKVVLIKAIKDILKEEKTINKNDITRRLNSIGFTVSRFTVIQYLKEIQDSGDL
                     KLDKESDDKKEEIINNRENKDIAFDKLIGSSGSLSTIIKLAKAAILYPPHGLHTIIMG
                     PTGVGKSELAECMYKFAVESSRFPKNAPFIVFNAADYSENPQLLLSQLFGHVKGAFTG
                     ADENKEGLVSKADGGILFIDEIHRLPHEGQEILFQLIDKGMVRKLGETRLTHKIDVMI
                     ISATSEPIDSHLLNTFKRRIPVTIEIPELVARPLNERFDIINNFFLIEAQRMGANIHI
                     KSDVLKALMLYDCIGNVGQLRSDIQVACARGLLNQLTNKLKEVNISISDVPGYVKQGL
                     IKIRNCRGKIENYVDGDLIIDSNLQGEIEKKNEDIYTFPDEIYKLTERRHIDLLEQGL
                     DFDVINRIIGGELESCIQKYIKQVKKVSISNNLPDISPIVGKYIVELTYEVIKIASQY
                     LSSLEPNLHLCLAVHLKAAFERLKEGKVISNAHLKEIIGNYPVEYSVAEKVAQYLKER
                     YNINLPKEEIGIIAIYFKMSSRRDMSEQKKIGVLLMAHGRVASSVCEVTNKLLGINHA
                     RYLDMPFEKKPEEMIEEATTIIKDIDEGRGVIILVDMGSLSYFGDIISGKTGINIRTI
                     SRFDTLLSIEVIRRAVLPDLTIDEIVDEVKGIEPQVKEKVSKCNNTKVDFRKPIILTL
                     CITGLGGACKIKKILEENIKSITEKVDIEPIGMIEYPSLDLEIKQISNDKNVIAIVGT
                     IDPQIANIPFFSLVDINDKAKLNQINNLIDTNQIGETNKKYELSDLIHKEDIFVDLQV
                     KSKEEVLKYMSKKLREKGYVTKNFYKKVVERDNLFPTELSDEIAIPHTDGIDVIRPAI
                     SIAILKKPIVWSKSKVKIILLLAVDQKCFNPLSTLLSFIETDEFKKIKNIKDRDFIRE
                     MILDGVNENN"
     gene            34101..34565
                     /locus_tag="KR257_002068"
     CDS             34101..34565
                     /locus_tag="KR257_002068"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892531.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIA"
                     /protein_id="HBH0030754.1"
                     /translation="MESMKIISSNLIFKNIEVSNNEDALKFLGQRLFDEQYVKESYIQ
                     AVVAREKKYATGLPTEIYGVAIPHTDIVHVNEPGIAIGILNKPVKFIMMGTDDTEIDV
                     KVVFMLAVKEPQEQLQLLEKLMTIFQDKNILNNIVDLSEESVSDLLNSKLKN"
     gene            34678..34980
                     /locus_tag="KR257_002069"
     CDS             34678..34980
                     /locus_tag="KR257_002069"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004453958.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIB"
                     /protein_id="HBH0030755.1"
                     /translation="MGVTNVAKKILVACGTGVCTSTIAINKLKKALQDIGKLDMVNIT
                     QCKVVEVASKAPDYDLIICTTQVSSSIKTPVINGLPFLTGVGMDKLINDVLEELEL"
     gene            35042..36406
                     /locus_tag="KR257_002070"
     CDS             35042..36406
                     /locus_tag="KR257_002070"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425524.1"
                     /note="with GatAB forms a phosphoenolpyruvate-dependent
                     sugar phosphotransferase transporter for galactitol;
                     subunit IIC forms the translocation channel and contains
                     the substrate binding site; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS galactitol transporter subunit IIC"
                     /protein_id="HBH0030756.1"
                     /translation="MEGLYMEILNFIVGLGAQVMMPIIICIFGLILGTKLGKSLRAGL
                     TVGVGFIGLNTIIALLTDNLGPATQQMVKNLGLSLSIIDVGWPAASAIAFASTVGALI
                     IPIGLVVNIVMLITNTTQTVDVDIWDYWHFAFTGALVAGATQSVMWGVFASVANMVIV
                     LVMADLTAPGIEEYLGMPGISLPHGFTQAFVPIAIVVNKLLDLIPGINKIEINADTLQ
                     KKFGLFGEPLIMGSVIGVIIGIAAKYDIKGILQLGVTMGAVLILIPKMAALLMEGLLP
                     VSEAAQEFIEKRFKNRGKIYIGLDSAVGIGHPVTLSVALVLVPLTILIAAILPGNKVL
                     PFADLAVIPFALVLIVPITKGNVFRTLIIGIIIITSGLLIATNLAPLFTQMALNASFK
                     MPEGATMISSICDGANPLSWVFVKVMNYKVIGGVVFGVIALGMAIYNRNRIINENKKL
                     SIEE"
BASE COUNT        14707 a         3996 c         6932 g        10863 t
ORIGIN      
        1 ccccttccag gtcgccaaaa taaaatgctg gtgtggctca acggtagagc agctgacttg
       61 taatcagcag gttgtaggtt cgattcctat caccagctcc atataaaatt aatacggagg
      121 atttcccgag cggccaaagg gggcagactg taaatctgtt gtcatcgact tcggtggttc
      181 gaatccacca tcctccacca aaaaaatgcg cggatgtggc ggaattggca gacgcactag
      241 acttaggatc tagcgccatt ggcgtggggg ttcgactccc ttcatccgca ccatttttat
      301 ttaatttaat aaacgagcgg gaatagttca gtggtagagc gcaaccttgc caaggttgaa
      361 gtcgcgagtt cgaatctcgt ttcccgctcc aaattttatg tttatgttgt aatgtgggtg
      421 catagctcag ctggatagag caacgccctt ctaaggcgtg tgtccggggt tcgaatccct
      481 gtgcgctcac cacatatata ttggggatta gccaagtcgg taaggcacat gactttgact
      541 catgtatgcg taggttcgag tcctgcatcc ccagccaaac agtatggtct attagctcag
      601 tcggtagagc acctgacttt taatcagggt gtcccgcgtt cgagtcgcgg atagatcacc
      661 aatggagagg tgtccgagtg gtttaaggag ctggtcttga aaaccagtga cttcgaaagg
      721 ggccgtgggt tcgaatccca ccctctccgc caaatgccca gatagctcag tcggtagagc
      781 aggggactga aaatccccgt gtcggtggtt cgattccgcc tctgggcacc aaaatgtggc
      841 ggtatagctt agttggctag agcgttcggt tcatacccga aaggtcatag gttcgactcc
      901 tattaccgct actaaaattt aatgtgggcc attagctcag ttggttagag cgcccggctc
      961 ataaccggta ggtctggggt tcgagtccct gatggcccac cacattaaat taacttatgg
     1021 tgggtatagc tcagttggtt agagcgccag attgtggctc tggaggtcgt gagttcgact
     1081 ctcattatcc accccaactt atatggtcta ttagctcagt cggtagagca cctgactttt
     1141 aatcagggtg tcccgcgttc gagtcgcgga tagatcacca aaaaggcggc gacatagcca
     1201 agtggtaagg cagtggactg caactccttg atccccagtt cgaatctggg tgtcgcctcc
     1261 aataaaatgc gctcatagct caactggata gagtgtctga ctacgaatca gaaggttagg
     1321 ggttcgagtc cctttgggcg caccatatga atagcgaggg attatagctc agctgggaga
     1381 gcacctgcct tacaagcagg gggtcacagg ttcgagccct gttaatccca ccagtgcaaa
     1441 cctctagtaa aactactaga ggttttattt ttgattgaaa aagtttttat atttaggagg
     1501 taaaaaattt gtatatagta ataggaaatg aaatagttga tagtgaagaa cttaaaataa
     1561 ttatagataa aaatagtgaa tttaaagttg aaaaagattt aagtaaaagc acaaaaagag
     1621 aagatgtaat agcatatcag ttaagtatag atttaaatta cctagattct cttataaatg
     1681 agcaatgtaa tttagccagt ctatctgatg aagagaaatt tgatgaatat atgactttgt
     1741 ctgatgaact tgcactggat ttagaagagt taatgccaaa atatacaata ataaatgcta
     1801 gagcatataa attagacgag gtagatggaa ttgtaaaaat aatactagct gtagcgtatg
     1861 cagatttagg gcacttaaaa ctttctgatg tagtaaagag gctatctaga caagtagatt
     1921 aggatatgaa tatgaactat attaaaaaaa tgtataaaat cttacgtaaa gatgaaaata
     1981 attatgtaaa catagaaaaa aacagtataa aatcaagtca attgtagaaa ttttcacata
     2041 aattcatctg aaattctgta aaaaatgcct taattttaat gaggtaaatc gagtttacac
     2101 agtctaaaaa ttacttatat ttataaattt atcttattaa ttaaggaact ttcttaaaca
     2161 tcttcaaaaa taaagtattt tagtctataa tctttaatat tacacaaaca ataaaggaga
     2221 agaatagagt atgcttaaaa agtttaataa aatactagtg gctaatagag gcgaaatagc
     2281 tataagaata tttagagcct gttcagaatt ggggataaaa agtgttggta tatacagtaa
     2341 ggaagataag tatggattgt ttagaacaaa agcggatgaa tcatatttga taggagaagg
     2401 taaagggcca atagatgcat atttagatat ggatggaata atagacctag caaagagaaa
     2461 aaaagttgat gctatacatc caggatatgg ttttctagcg gagaatgcag aatttgctcg
     2521 taaatgtgaa gagaatggaa ttacttttat aggaccatca tctaaggtaa tgaatatgat
     2581 gggggataag attaactcta aaaaaatcgc aaaagaagtt aatgttcaaa ctataccagg
     2641 agtagaaaaa gcaataagaa gtactgaaga agcaaaggaa gttgcaaaca aaataggata
     2701 tcctgttatg ataaaagcat ctaatggcgg tggcggtaga ggtatgagaa ttgtacatcg
     2761 cgaagaagac ttagagcttg aatatgaaac tgcttgtagt gaatcaagaa aagcttttgg
     2821 agaagatatt atatttatag aaaaatatat agctgatcca aaacatatag aagttcaaat
     2881 attaggtgat aattatggaa atatagttca cttatatgaa agagattgtt cagttcaaag
     2941 aagacatcaa aaaataatag aatatgcacc agctttttcg ttagatgata aagtaagaaa
     3001 agagatatgt gaagatgcag ttaagttatc aaaacatgtg ggttattcta atgcgggaac
     3061 attagaattt ttagtagatg caaatggtgg gcattatttt atagagatga acacaagagt
     3121 acaggttgaa catactgtaa cagagatggt tacaggaata gatatagttc aaagtcaaat
     3181 actaatagcc caaggttaca gcttagatag tgaagaaatt aatataaaat cacaagatga
     3241 tgtggaaata agaggttact ctatccaatg tagaataact acagaagacc ctaagaataa
     3301 attcatgcct gatacaggta aaattcaagt ttatagaact ggttcaggat ttggtataag
     3361 actagatgga ggaaatggat ttacaggggc aaacataagt cctcattatg atagtttatt
     3421 ggttaagaca atatcttggg atagaacatt ccaaggagca ataaataaaa ctataagatc
     3481 tataaaagaa cttagagtta gaggtgttaa aactaatgta ggattcctag ttaatgtttt
     3541 aaataatcct atattctcaa atggtaaatg tagtactaag tttatagatg aaaatccaga
     3601 tttatttgaa ataacagaaa gtaaagacag aggaacaaaa ttacttcaat ttataggaga
     3661 tgtaattgta aatgataatg cttgtaaaga aaaaccatta tttgatgcat tacatgaccc
     3721 aagaatggat aaggatggtt caaaatcaga aggaagtaaa atacttttcg ataagttagg
     3781 taaatctgca tatatagaaa agataaaaaa tgataagaaa ttactattaa cagatacaac
     3841 aatgagagat gcacatcaat cattattagc aacaagaata agaacatatg acttattaaa
     3901 agctgctaag ccaacagaaa aatatcaaaa ggatttattc tcacttgaaa tgtggggagg
     3961 agctacttat gatgttgcat atagattttt aaaagaatct ccttggcgta gattacaaaa
     4021 gctaagagaa gaaataccaa gcataatgtt ccaaatgttg cttagagcat caaatggagt
     4081 tggatataaa aactatccag ataatgtaat agaagaattt acaaaagaat ctgctagaca
     4141 aggtatagat gtatttagaa tatttgattc attaaactgg gttgaaaata tgaaaccatc
     4201 tattaataca gctttagaaa ctggaaaaat tgttgaagca actatgtgtt atacaggtga
     4261 tatactagat aagactaaaa ctaaatacaa tctagaatat tatattaaaa tggcacaaga
     4321 attagaaagc ttgggagcag atataatagc aataaaagat atgtcaggtc ttcttaaacc
     4381 atattcagct tacacactag ttaaagagtt aaagaaaaat gtaaaagcac caatacattt
     4441 acacactcat gatacaagtg gaaatggtgt agcaacttgt ttaatggcgt cagaagctgg
     4501 agtagacata attgatgctg cattagaatc tatggcagga cttacaagtc agccatcact
     4561 taatgctata gtagaggcac ttaagaatac agagagagat acaggaatag atttatttgg
     4621 atatgatgag ttaggaaaat attataagga tttaagaaaa gtttataata aatttgaaag
     4681 tgatttaact aattcttgtg cagaaatata taattttgaa ataccaggag gccaatatac
     4741 aaacttaaaa cctcaagctg atagtttagg attagttaat agatttgatg aagttaaaga
     4801 aaaatataaa gaagctaatg aagttgtagg agatataata aaagtaactc catcttcaaa
     4861 agttgtagga gacttagcta tctttatgac taaaaataaa ttagataaag ataatataat
     4921 agaagaaggt aaaaatttat cattcccaga ttctgttgtg gattactgta aaggtatgat
     4981 tggtcaacca gaaggtggaa taccaaaaga tttacaagag gtagttctaa aaggtgaaga
     5041 agctataaca gtaagaccag gttcattatt accagcagaa gattttgatg aaatagctaa
     5101 atatctaaat gaaaagtatg atataaatgc taatataaga aatgttataa gttatgcttt
     5161 atatccaaaa gtatatgaag attatatcaa acatctacaa cattataatg atatatctaa
     5221 acttgaaagt gatgtattct tctatggatt aaataaaaat gaagaatgtg aagtagaaat
     5281 agaagaaggt aaggtattaa caataagatt agttgaaatt ggtgaagtta aggaaaatgg
     5341 atttagaact ataggatttg agttaaatgg aatggttaga gaagtagaaa taaaagataa
     5401 gaatttctct ggaaaaatta ataatgttga aaaagctgat atgaatgacc ctcttcaaat
     5461 tggagcaagc ataccaggaa aagttataaa aataatggtt aaagaagaag atgaagtaaa
     5521 agcaaatcaa ccattaatcg ttatagaggc tatgaagatg gaaactataa tagttgctaa
     5581 gactgatgga gtaattaagt caatcaaagt aaaagaagat gatatggttg aagataaaca
     5641 attattaatg ataatgaagt aatttaatta aaataaatta aaaagcactc tgaaatgttt
     5701 aataaaaaat gttttagagt gtttttattt attttaatta aatatttgtt aaaaaaaaga
     5761 ggacaattac ctccagatgt agaaataaag ctagtaagga aaatgttatc taaaaattct
     5821 aaatatagta aatattttcc ataatatttc ttaggaaata acagcaaaga taaaatacat
     5881 aaatttaaaa ggtgggtgct tatatgaagg tttatgatag taaaatgttg agaaatgtag
     5941 cggtattagg acatagcgga tgtggaaaaa caaatctaat cgaaactata gcttacacag
     6001 caaacactaa taagatacct aaattaacag acaaggtaaa tatgacttat agcatgggat
     6061 taatacctat agagtataat gattataagt ttaacttatt ggatacccca ggatattttg
     6121 actttagcgg agacgttgtg tcatctctta gagcaagtga tgcagcaata atagtaatag
     6181 atgcaacagc gcctattcaa gttggtacag agaaatcatt agaactaact gagagtattc
     6241 ctaagataat gtttataaat aaaatagata atgaaaaggc aagatacaaa gatgcaatag
     6301 caatgttaag agaaaaatac aataataaga tagttcctat gataagtcct atatacaaag
     6361 ataaaaactt tgtaaagtta cataatgttt ttgaaaacat agatgattta gaaggtgaat
     6421 ttaaggaaca agctatgagt gttaaagaag cattaatgga acttatagca gaaactgatg
     6481 accaaatatt agataaatat tttaatggag aagaactaac tacagaagag atacaaaaag
     6541 gtattattat aggtatacaa agaggtgata ttatacctgt aatatgtggt tcaactataa
     6601 ataatatagg cacaaaggaa atattagata caatatcaag ttatttagaa cctatcttta
     6661 cagaggaaag caaaccattt aggggattag tatttaaaac tatggttgac ccatttgttg
     6721 gaaagatgtc atatataaaa attactgagg gtgtactttc taaggataaa gatgttttta
     6781 atataaataa aaatgtaaaa gaaaaaatag ctaatatata tacattgaga aatagtgaat
     6841 tagtagaaat agaaaaagct aaagctggtg atatagtagt tataactaaa gttaattctc
     6901 taaaaacagg agacactata tctgcagata aagatgcaga agctttagaa aagatagatt
     6961 ttcctaaacc acaaatatat tatgcagtaa ctcctaagaa taaaggtgat gaagaaaaag
     7021 tagcatctgt attaaataaa ctagtagaag aggaccctac attacattgg tatagaaata
     7081 cagagacaaa acaagcactt ttaggaggtc aaggagaact tcatataaaa acaattaaaa
     7141 ataaaatgaa agataagttt ggtgttgatg ttgaattgaa tgaccttaaa gttccttata
     7201 gagaaactat aaaaggaaca gctgatgtac aaggaaaaca taaaaagcaa tcaggtggtc
     7261 atggtcaata tggagacgta aaaataagat ttgaaagatg tgaatctgat tttgaattta
     7321 cagaagaaat atttggtggt tctgtaccaa aacaatatat accagcagtt gaaaaaggtt
     7381 taaaagactc tatgcaaaaa ggtatattag caggatatcc tgttacaaac ataaaagcta
     7441 cgctttatga tggttcatac catgatgtag actcttctga aatggccttt aagatggcag
     7501 caagtgcagc ctttaaaaaa ggtatggaag aagcacaccc aatactacta gaacctataa
     7561 tgaaacttaa gataactgtt ccagaagaat atatgggaga tgtcatgggt gatataaata
     7621 agagaagagg aaaaatattt ggaatggaac cagatgacaa agggaaacaa ataatatttg
     7681 cagaagctcc acaagcagag acatttaaat atgcaataga tttaagagca atgacacaag
     7741 gtagaggata ctttgaaatg gaattagaga gatatggaga ggttccatca cagtttgcag
     7801 aaaaaataat tgggttagct actgcaaagt aatgaacaaa ataaatagaa aaataattaa
     7861 tatatattat taaaaatatt tttagggttt taactaggta taggtttatg ttaggtaaac
     7921 ttatacctag tttttataca tttttgatga ataaaaaaat atataatact ttcttaaata
     7981 ttttaataaa aagaaagtat ttttttatta ttatttttac aaatgtttag taataaagat
     8041 gagaaggtat atttaaaata taaagtattt aaagttctga aatctaatca tgaagcaaaa
     8101 aattagcatt tggttatcaa taaatataat aaataaaaac tcataattaa tgaaagaata
     8161 aattcatgtc taaatttcta taaaaaattt aaatttatac aatttagggc tttaaaaatt
     8221 taaataatag gtgtaaaata atagtcaaag aaagtcaaaa ataaaaaggt gtgtggtgat
     8281 attaatggca actatgacag atataattga aaaatttatt aaagatttga tggaagaaga
     8341 taatagcata caaattcaaa gaaatgaact agcaaacttg tttagttgtg caccatcaca
     8401 aataaattat gtcttaacaa caagatttac aatagataga ggatattaca ttgaaagtaa
     8461 aaaaggtggc ggaggatatg ttcaaataga aaaaatacga aaaagtaaag atgggcatat
     8521 tagagaacta ctaaatgaaa aaataggaag tcagatatcc tataaaaaag caaaagaatt
     8581 attagaaggt ttaaaagagt cggatttgat taacgaaaga gaattaaaat taatattata
     8641 tgcaatagat gataaatcat tgtgtatgcc aatatatgaa ttaaaagaga aggtaaggtc
     8701 taatatttta aagaatataa taataggatt atttagtata gaggagtgat aatttatgct
     8761 atgtcaaaaa tgcaataaga ataaagcatc tgtatattat aataagatag tcaatggaga
     8821 aaaaacagag atgtatttat gtagtgagtg tgcaaaagag aatacagaaa tgaattttaa
     8881 cttagatatg cctttttcaa tgatggatat attttctaat ttaggttttc aacctaaaaa
     8941 agaacttgag gaaaagctag tttgtcctaa atgcaataca acatatagtg agtttaagaa
     9001 taatgggaga tttggatgta gtgaatgtta taatgcattt agtagtcaag taaatccaat
     9061 gcttcaaaat atacatgggc atatagaaca tacaggaaaa gcacctaaaa aatcttttta
     9121 taagataagt gtagaaaatg agattaaaga actaaaagaa gatttagata gagctataaa
     9181 aaatgaagag tatgaattag cagctcaatt tagagataaa attaaatatt taaaaggttc
     9241 tattgactaa gattggagtg atattatgaa agagaacata gtcatgaaat caagagttag
     9301 gctagctaga aatttaaata actatccatt tccaaataaa ttagataaag aatgtgccat
     9361 ggaaataata gaaaaagtaa aaaatgcgtt tattaattct aacttagaac aaaaagaaga
     9421 atttgatttc tataaaattg aagatttaga ccaatctaaa aaaatgctta tggttgaaga
     9481 acatataata agcccagatt tagcagaaaa tgataaaagt gcagttatag taaaaaaaga
     9541 taaaactata agtataatga taaatgaaga agaccatata aggatacaaa ctatatgtga
     9601 tgatttaaac ttagaatatg catatagtgt agcaaatgaa atagatgatt tgttagaatc
     9661 aagtttagaa tatgccttta acacaaagct aggttatcta acatcttgtc caactaatac
     9721 aggaacagga atgagagctt ctgtaatgat gcatttacca gcattaagtc aactaggcta
     9781 tatggatgaa ctttataaaa tttcatcaca aataggtata gcaattagag ggatatatgg
     9841 agaacgaaca gaagcattgg gaaatatata tcaaatatct aatcaactta cacttggaag
     9901 aacagagtct aatattatag aaaatgtaag tggacttaca aaagatgcaa tttcaaaaga
     9961 aataaaagct agagaaatat tgcaaaaaaa attaggtata aaactagaag ataaaatatt
    10021 tagatcgata gggacacttg aaaattcaag agtaatgagt agcgcagagg caatgagcca
    10081 tctatcaaat ataaaaatgg gaatagaaat gaactatata gataaactag atttaagggc
    10141 tatagaacaa cttatgatag gtatacaacc agcgcatcag tcaataatgt ataagagtga
    10201 tgatgttgag aatagagata taaatagagc aacatatatt agagaaactt tggaaaaatt
    10261 aagaggaggg atgaattgtg aacttcaata gatttacaca aagagctaaa aaggcaattg
    10321 atttagcgtt tgaatctgct aaaagtctag gacacaatat tgtcggaagt gaacatatac
    10381 ttttaggtct tttaagagaa gaagaaggta tagctgctaa agttctaagt aaagttggat
    10441 ttacagaagc ttatttagaa ggcaaaatag ttgatatgga aggtaaggga gaagaaatct
    10501 cagaagatat agtattaagt ccaagaagta aacaaatact tgaattatca ggaatgtttg
    10561 caaataaatt aaaaacaaat tatattggga ctgagcatat attattagca attattcaag
    10621 aaggtgaagg aatagctaat aagattttaa attatgctgg agtaaatgat aggactttag
    10681 cccaattaac aattgatatg atgggtatta gtgataaaaa tcaatacaaa gcagaaaata
    10741 gttacacggg caaccagaat caagcagaat ctaaagtact tgataagtat ggaagaaatc
    10801 ttacactata tgcaaaacag aataaaatag accctgtaat aggtagagaa aaagaaatac
    10861 aaagagtaat acaaatatta agtagaagaa ctaaaaacaa tccagtgttg ataggagacc
    10921 caggtgtagg gaaaacagcc atagctgaag gtctggctac aaatatagcc ttaggaaatg
    10981 ttccagaaac actaaaaaac aaaactttat actctttaga gatgggttca ttattggctg
    11041 gggctaagta tagaggagaa tttgaagaaa gaattaaaga agttgtagat gaagttgtta
    11101 aaaatggaaa cataatctta tttatagatg agatgcacac aataataggg gctgggtcta
    11161 ctggagaagg ctctatagat gcttcaaata tattaaagcc agccttagca agaggagaaa
    11221 tacaagttat aggtgcaact acaattgatg aatatagaaa gcatgttgaa aaagattctg
    11281 ctctagaaag aagattccaa ccagttatgg tagatgaacc aactaaagag gactcaataa
    11341 aaatattaga aggattaaga gataaatatg aagctcatca taaagttaaa ataactgatg
    11401 atgctataaa ggcagctgta gaattatcaa ctagatatat atcagacaga tatctgccag
    11461 ataaagctat agacttgatt gatgaagctg catcaaaagt aagattaaaa gaaaatacac
    11521 ctccttcaga aataaaaaaa ttagaactag aaatagaaaa tatagataaa gaaaaagaag
    11581 aagcagtaag atgtcaagac tttgagaaag cagccaaaat aagagatgaa caaggtctac
    11641 ttaaaaaaca attagaagat gttagagaaa gatggaacaa gtcatctaaa cattcagatt
    11701 tagttgatgg agaagttatt gctgaagtag tgggcttatg gacaggaata ccagttaata
    11761 aaattcttga agaagaggct gatagacttt tgagacttga ggaaatactg cacaatagag
    11821 ttataggtca agaacaagca gtaaaatcta tttcaaaggc aatcagaagg tcaagagcag
    11881 gtcttaaaga ccctaataga ccaattggtt catttttatt tttaggtcca acaggagtag
    11941 gtaaaacaga attatctaag gcattagcag aagtgcaatt tggagatgaa aatcaaataa
    12001 ttagaataga tatgtctgaa tatatggaaa aacatgctgt gtcaagaatg ataggttcac
    12061 ctccaggtta tgtaggtcat gatgaaggtg gtcaattaac tgaaaaagta agaagaaatc
    12121 catattcagt tatattattt gatgagatag aaaaagctca tccagatgta tttaatattc
    12181 tgttacaaat tctagatgat ggtagactaa ctgattcaaa aggaagaact gtagatttta
    12241 agaatactat tgtaataatg acatcaaatg ttggagcatc tacaattggt agacaaaaaa
    12301 ctttaggatt tagtatagct aaaggagacg aagaagaaaa atctcaatat gaaaaaatga
    12361 aagaaaatat aatgggtgaa ttaaaacaaa gattcagacc agagttttta aacagaatag
    12421 atgatataat tgttttccac tcactaaatg aaaatcatat atcaaaaata gtacttttaa
    12481 tggcagcgaa actacaagag agattaaaag aaatggatat aaaattagaa atgagtgatg
    12541 aggctgttaa attaatttct aaatctggat ttgacttaga atatggagca agacctctta
    12601 aaagagcttt acaaaaagag ttggaagatg agctatctga agcaatctta aaaggtaatg
    12661 tgaaaaaggg aagtaatgta gtagcaaaag tcaaagatga aaaaatagtt tttgaaacta
    12721 aataatttaa tagagttgca ttttaaaata ttgcaaatat aagttttata atctaaacaa
    12781 aattttaagg gcaatgaatc tataataatt cattgtcctt aattatttta tttaatcttt
    12841 acatattgtc tttcagatat gctaaaatta tagtatagaa taaaaaatta aggatgataa
    12901 aagtatggca aaaataaaaa caaaatatgt atgtcaatct tgcggatatg aaacagctaa
    12961 atggcttggt aaatgtccag aatgtacaaa atggaataca tttgtagaag aaatagacca
    13021 aaaaagcacc aaaaaagagg tctttataat agataaatct tcatctaaac cagtcagtat
    13081 aaactcaata gaaagtaaag aagaagagcg gtttacaaca gatataaatg agttagatag
    13141 agtgcttgga ggaggtatag ttaaaggctc tttagtgctt gttggtggtg accctggtat
    13201 aggtaaatca acacttttaa tccaagtatc tagtaatgtt gccaatttag gaaaaactgt
    13261 tttatatata actggagaag aatcagaatc tcaaataaaa atgagagcta aaagattagg
    13321 tattaactca gaaaatttat atatatttgc tgaaaataat ttaagtataa ttgaatctta
    13381 tttagaaagt gtaaatccag aattaataat tctagactca attcaaactg tcttcagtcc
    13441 agaaatatcc tcggcaccag gaactgtcag ccaaattaaa gaaggtactt caaaattcat
    13501 gaaaatttct aaaaaaatgg gaatttcaac gttcatagtt gggcatgtta caaaagaagg
    13561 ttcactagca ggaccaaaat tattagagca tatggttgat actgttctat attttgaagg
    13621 agaaagatat aatacttata gattagtaag agctgttaaa aatcgatttg gttcaactaa
    13681 tgaacttgga gtatttgaaa tgagggattt aggattagta gaacttgata atccatctaa
    13741 aattttaatc tctgaaaaac caaaagatgt agcaggttca gtaataatat ctactgtaga
    13801 aggtacgaga ccaatgttac ttgaattgca agcattagtt tctcctacaa gttttggtat
    13861 accaaaaaga acatctacag gagtcgatta caatagagta ggtatgttat tagcagtatt
    13921 agaaaaacgt gttggtttgc aaatacaaaa tcaagatgtc tatataaaca tagttggagg
    13981 aataaagata aatgaaccct caattgattt agggatagcc atttctgtag catctagttt
    14041 tagaaatata ccgatagatg aagatatagc tgttacagga gaagtgggac ttacaggaga
    14101 agttagagca gtaagcttta tagaaaagag aatagctgag tgtaaaaaac ttggatttaa
    14161 aaagatagta gttcctagaa gtaattatga tgttgtaaaa gagaccaaag gcatagaaat
    14221 atggccagta gataacttaa gacaagctat aaatatagta cttgggagga atcaataaat
    14281 atggagaatt ttctagataa taaaaatatg ctatatgcat taaaaatgat atctcctgga
    14341 actccactta gattaggtct aaacaatgta ctaagagcta agactggtgg attaattgta
    14401 attgcaacaa acgaagatgt aatgaaaata gtagatggag gatttgctat aaatgcagaa
    14461 tattcaccat catatctata tgaattagct aaaatggatg gagctatagt tttaagtggt
    14521 gatgtaaaga aaatattatt tgctaatgca caacttatac ctgactattt tatagaaaca
    14581 tcagagacag gaacaagaca tagaacagca gaaagagtag caaaacaaac tggtgctata
    14641 gtcataggaa tttcacaaag aagaaatgtt ataacagttt atagaggaaa tgagaagtat
    14701 gtagtcgaag atatatctaa gatatttact aaggcaaatc aggctataca aactctggaa
    14761 aaatataaga cagtattgga ccaagctgta acaaatttaa atgccttaga gtttaatgat
    14821 ttggtaacta tttatgatgt tgcattagtc atgcaaaaga tggaaatggt aatgagagtt
    14881 acaagtataa ttgaaaaata tgtgatagaa ttgggtgatg aaggaacttt agtaagtatg
    14941 caattagaag aattaatggg tacaaccaga atagaccaga aattaatatt caaagattat
    15001 aataaagaaa acacagaaat aaaagaactt atgaaaaagg tcaaaaattt aaattcagaa
    15061 gaactaatag aattggtcaa tatggcaaaa ctattagggt atagtggttt ttcagaaagt
    15121 atggatatgc ctataaaaac aagaggttat aggattctta gcaaaataca tagactacca
    15181 acagcaataa tagaaaactt agtaaattat tttgaaaact ttcaacaaat tttagatgca
    15241 tctattgaag aattagatga ggttgaagga ataggtgaaa taagagcaac atatataaaa
    15301 aatggactca taaaaatgaa acaattagtc ttattagata gacacatatg atgaatttta
    15361 aatgaatttt actacttttt tcttgaatat aatatacact ttggtctata atagataagt
    15421 ataactaggg ggtgaagcat tgataaggaa agtaacaaga atattgttta ttttacttgg
    15481 atttacaata ggtataacaa cctatttaac attaatgaaa gattttgaaa tattaacatt
    15541 tggaaaagaa acatatggtt atatcgcagc tgtagtagca ggtataataa tagccatttt
    15601 aggatatctt atagaaccat gggttgtaaa taaagtaaaa gaaattgcta aaatagtgga
    15661 taaagaattg tcaaaatatc ctcagactga tatattgtta gggtctatgg gtcttatagt
    15721 aggatttgtt attgcgtatt tattaagtgg attagtaaat agaataccaa tagtaggtgg
    15781 aatactatcc ttactattat atttattcct aggatatctt ggaatgaaag ttgcgcttaa
    15841 aagtaaaaat gatttattta atattggaaa actaggaaga ttagcaaatc ctattaagga
    15901 taaagataag gataaagaaa ataaaaaaga agtaaaagcc attcctccaa aagtattaga
    15961 tacaagtgta ataattgatg gaagaatagc tgatatttgt aagactgggt ttatagaagg
    16021 aaaacttatt attcctgctt ttgttttgga ggaactaaga catattgcag attcttcaga
    16081 tgatttaaaa agagtaagag gtagaagagg tctggatata ttaaatataa ttcagaaaga
    16141 attaaatata gaagttgaaa taagtgagag agactttgat gatatagcag aagttgatag
    16201 taaattatta aagcttgctc aggttttaaa tggaaaagtt gttacaaatg attataactt
    16261 aaataaagtt gctcaattcc aaggtgttga agtattaaat ataaatgagt tagctaatgc
    16321 tataaaacca gttgctatac caggtgaaga tatggttgtt caagtggtta aagaaggaaa
    16381 agaggctcaa caaggtgttg catatctaga tgatggaact atgatagttg ttgatggagg
    16441 aagaaaatat atgaatgaga ctataaaagt actcgttact tctgttcttc aaactcctgc
    16501 aggtagaatg atatttgcaa aacctaaaaa ttaatatgtt caaagaaacc tataatttgg
    16561 gctgtttatt ttaaatagat ggtccaaatt tatttattta taacgataat gtttaatgta
    16621 ttcttaaaga tggggattta aatcagaaag cagggagaat ttatgagaaa aaagattata
    16681 tctttcttag caacatttat cataatatta acatcagcaa gtcagtatag ttttgcagat
    16741 gatatatcaa cacgtggaaa agtaatattt atagatatga atagaactag tatgagtaat
    16801 atgttaagaa taaaatcatt aagagaagaa ctagacaata gagggtatat tggcttgatg
    16861 aatataagag gcgataaagg aagtgatgat agaaggtcat atgctagtat gggtgctggt
    16921 ggtagagcta atgtggctaa tgaagaagat attaattttg aaagctcgag taaggataga
    16981 aatatagttt ttgaatcagc tacaggaaaa agtgcaaaag gtataaataa tttaactata
    17041 aataagtcta taaatgaaaa tttaaacttt ggagagtatg gttctgtatt agggtcatta
    17101 ggacaaagtt tatctgataa tggattaaaa gcatctgtat tgggtaattc agatataatt
    17161 gaaaatggtc aacttataaa aaatagaaac ttatgtctaa ctgcaatgga tgaatatgga
    17221 agaataccta atggaaatgt agatactata aataaaaaag acttatctat gccttatgga
    17281 atatcaactg attatgataa attgattgta gagactaaag aaacttacaa aaataatgat
    17341 gtgatttttg tggagcttgg agacacatat agattagatt tatataaacc aaatttaaat
    17401 gaaaaaacat atgagagtat gaaagataac atagaaaaaa atatagatat atatttaaaa
    17461 aatatatttt ctatggttga agaaaatgac actatctaca tagcaagtgc atttccaagt
    17521 gatttagatt ataaaaataa aagaagactt tctccaataa taaaattaaa tggagaaggg
    17581 aaaggtatat tatcatcttc aactactaga agagaaggta ttgtaacaaa tttagatgtt
    17641 ggggttgaaa tattagacaa ctttaatata aaaaatcaaa atatggttgg aagaaaatat
    17701 gaacttatta acagagatga taataaagaa tttttgatgg atgaatatca aaagatagta
    17761 tctatttcaa gcataaggtc tacaatactg aatggttttg taagtatagt tttcttgtca
    17821 tggatagttg ctatgattgc aattttattt agaaagcata tatcaaaaaa ttataaagaa
    17881 acaacatttt ttatattaaa ggaactttta aaaataggaa tagtaatgcc actgtcattt
    17941 atgataacac caataatgaa tttcaaaaca ccattagcaa tatctttagg aataattata
    18001 ataacactta ctatatatct tataagtaaa gttttaataa agaacgattt aaaaaacatg
    18061 ctgtttttta ctggattaac catagtaatt atggttattg atgctgggtt tggctcatat
    18121 ttaatgaaaa gcaatgttat gagttatgat tgtataattg gagctagata ttatggagta
    18181 ggaaatgagt atcaaggtgt ggcaatcggt agtgcaatat ttacatttgc aattttactt
    18241 acatataaaa atataccaaa gtggtatata atagtttttt ctttggttat cttaattaca
    18301 agtgcatctc caattatggg agcaaatgtt ggaagtgcta tttctgaatg tgttgcattt
    18361 ttactattta tactattgat atataatgta aagatagatt tcaaaaaaat cgtattatta
    18421 ggtatagcag tagtatttgt attaggagtt tttgtagcaa tagatatgat tttgggaagt
    18481 aattcacatt taggtatgtt tgtaaaagaa atttacttta atggaccagg agaaataata
    18541 caaacattta gtagaaagat agagatgaat ttaaagctag ctcaaaccag tgcatgggta
    18601 aatatactgt taactggaat aggtgtaatt ttagttctta tgattaatca gattagatac
    18661 tttaagcaac tgatggatga gtatccaatt gtatttaaag gatttatagc atcaatagca
    18721 ggatgtttag taactctttt agtgaatgac tctgggattg tgtcatcagc tacagccttt
    18781 atttatgtaa ttgtacctat gataacatta agtataaatc ttacagcatt aaaagaataa
    18841 gtactgtatg aataatatgt aaatattaat acattaattt aacttcttta tttacaaaat
    18901 aaagaagaaa gtttataaaa aataaattat aataaaaaag agtttatctc aaaattgatt
    18961 attctaatca aattttaaga taaacttttt ttattataaa gataaataac atataacctc
    19021 atattttagg tagatttttt tcttatatgt ttaggagtgc atttaaattt ttccttaaaa
    19081 attctgtaaa ataattttgt attagtaaat ccatgagctt ctaatatact gcataaggta
    19141 tcatttgtgt taattaaatc tttataaata tgagaaatac gcacatcatt taaatactct
    19201 aagtaagttt gtcccatata ctgtttaaat tttctacaaa aatattctgg ttgtaagtgt
    19261 gctaccttag cgattttgtt aatagaaata ggcattttgt aattaatctt tgtatattct
    19321 aaaactggtt caaattttga caaatcaagt actgtttttt tcatattttt attacctaca
    19381 gatattttaa agtttgtata taattcaaat aaaagttcaa ataataagct tgtaaagagc
    19441 agattagctg caggaggaga actaagttta atttctctca tgttttctaa tataagttta
    19501 actttacttg aatttttttt atagttattg tcattggcat taaccttaaa gtcaaaatag
    19561 caatttttaa aatcagggat atatttgttt agaaaagaca atggtacttg caataatata
    19621 gaggtatttt gataaataca tctagttgag tgaataattc cagaattaat gaacatacac
    19681 tcattagctt ttaaattata agtgtaaccc tccatgttaa tttgtaaatc accagaagtt
    19741 atataaatta tttctaatga gttatgccaa tgatttgcta cataactacc actatcatca
    19801 aatagtttga aattaacatc taaattatca ataggttcaa ttatttcatg tgaaaaatta
    19861 tttctgttca taataatatc ctccttataa ttttaaatta taaatagtaa atttataatg
    19921 ttcaatatta aaaagataat atagactaat aaattagata ataaacatac ttaagaaaac
    19981 ggataaaatc aaatataata actgtatatt aaaataactt aaaaaaatta ttttattata
    20041 agtgcaaaat atacctattt aaataagata agaggggagg attttatgtg tatataaaag
    20101 gtgtaaattt aggaggttgg ttagttttag aaaaatggat gacctcaagt ttatttgaag
    20161 gcacagaagc tgaagatgaa tactatttac caagacagct ttcaagagag gcatatgaat
    20221 ctagaattaa gactcatcgt agtgaataca tcacagagag agattttgca acgattaaat
    20281 ctatgggatt taattcagtt cgtataccag taccatactt tatttttgga gattgtgaac
    20341 cattcatagg atgtgttaaa gaacttgata aagcatttgc ttgggcagat aagtatgggc
    20401 ttagtatatt gatagactta catacagttc caggaagcca aaatggattt gataatggag
    20461 gaatatcagg tatatgtagc tggtcacaaa atccagaata tgtagcgttt acattaaatg
    20521 tattagaaag acttgcaaaa cgttatggga tgaggcatga attgtatgga atccaaattt
    20581 taaatgagcc tataacagaa agaatgtgga acataatgaa tgttccaaat cggtttaagg
    20641 ctgtagataa ggagatggca agggggagta aacctaattc attagagttt ttacgtgatt
    20701 tttatataaa agcatatagg gtaatgcgtc cttatatgag agaggaaaac gttatagtgt
    20761 ttcatgatgc atttgaatta aaagcatgga aagactttat gagagaggaa gaatttaaaa
    20821 atgttgttct agatacacac caatatttga tgttagctga agcagatgga tgtgaacaaa
    20881 gtattgatag ctatctcaaa tatattagag aaaattatgc taaagatatt ttacaaatgc
    20941 aaaaatattt tcctgttata tgtggggagt ggagcttatt taattcatat gtttgtggta
    21001 tagatacaaa tggaggtcaa tcacctctaa atgggattga atcaaatata gataaattat
    21061 caaaagacga taaaagagaa ttatatagga agatagcaaa agcacagctt gatgcatgga
    21121 gaaatggaag tggtcactac tattggaatt ataagttatt actagataca gttaatgaag
    21181 aaggttggat aggatgggat agttgggacc taggcaaatg tgtagctcaa gaatggtatc
    21241 ctatagaata ttaaactaaa attggaggaa aagatatgat taaaaaccct atacttccag
    21301 gttttaatcc agatccttgt atttgtagaa agggagatga ttattatctt gtagtttcat
    21361 cttttgaatg gtttccaggt atacctgttt atcactctaa agacttaaaa aattgggagt
    21421 tatatactca tattttgaca gatgaaacaa aaatagattt gaagaagctt ccttcatcta
    21481 aaggaatttg ggcaccctgt ttgacttatt gtgaagaaga agatttattt tacatagttt
    21541 atggaattat gaactctatg aatgcaagat attttgatgt tgataattat ttaattacat
    21601 caaaagatat aaagggagag tggagtgaac cagtatatct acactcatca ggttttgatg
    21661 cgtctatttt tcatgatgat gatggtaaaa agtggattgc atcattagac tgggagacta
    21721 gagaaggata tgaaaaacct ggtgttatat gtttagtgga atactgtaca aaaaagaaag
    21781 aaatagtagg atatccaaag agaatatggt cagggggaac tgatagaggt tgtattgaag
    21841 caccacatat aacaaagcgt ggagattact attatataat gtgtgcagaa ggtggaactg
    21901 gatatggtca tagtgtaact atgggaaggg ctaaaaatat atggggacct tatgaaaaag
    21961 attcaatgaa tccaattgta acttcaattc caggcgattt ttatgaaaga catgaccctg
    22021 accatctaaa gcctaaatac tataatccag aatcaaaact tcaaaaatct ggtcatggaa
    22081 gctatataga aacaacatca ggtgaagtat atttagttca tctaacatct agaccatttg
    22141 taccagagtt aaggtgtact ttaggtagag aaacagctat tcaaaaaatg aaatggacaa
    22201 aggataattg gcttcgaatg gaagatgaaa gtaatttggc aaaagaatac gtatcagaaa
    22261 gtaaactaga agaacattta gtttcatcta taccaagttt tgatgacttt gattcaaatg
    22321 aattaggttt acagtactat gctcctagga tttcaccatt atcatttgca gatgttaagt
    22381 ctagaccagg atatgtaagg attagaggac aagaatcaag aacatcatta aataaagtaa
    22441 gcatattggc aagaaaatta acttcagtat atgcaagaat aaccactaag atggagtttt
    22501 acccagaggt acatcagcat agtgcgggtt tgataatgta ttatgataat atgaattata
    22561 taaatttaag aaagtattat agtgaaacat tgggtcaaag tgcactatca ataatacatc
    22621 ttgaaaatgg agagaaaacg gaatttttaa atactaggat accaataaaa gatataccaa
    22681 tatatcttcg tctgtatata caaggtcgta agtcatattt tgaatggagt tatgatgaaa
    22741 aaaactacca gagaatagga aaggtatttg atacaactaa gttttcagat gagtactgta
    22801 aatatggaga atttacaggt acgtttatag gattaacttg tgcagatcgt gtaaagcata
    22861 aacactatgc tgattttgat ttttttgaat atatagtaga tgaatcaaaa gatgtcgatt
    22921 aataaaatca ttactaaaat tttcagagca aaggtaaatc ttatgctctg aaataagaaa
    22981 cattagaagg caaatcttac aaaaaggagt atggtattat gaatacagaa gttaatgtta
    23041 aagcaactac gattagatat gaaaagattt cattttttga aagaatttct tatggttgtg
    23101 gggatttggg gtgcaatatc atatactcag ctatgtcagc atttttgctg ttttattata
    23161 ctaattatgc agatgttagt gcagcagctg taggtagtat tatgcttgta tctaggatac
    23221 tggatgggtt tagtgactta acaatgggaa ttatagtgga tagaactaaa tccaaatacg
    23281 gtaaggctag gccttggatt ttgagaatgg cgattccttt tgctatagca gcagtattat
    23341 tattttctgt tccatcaaat cttggtatca cttctaaatt aatttatatt tttattacat
    23401 ataacttagt ttctactgtt atttatacag caatcaatgt accctatgca actctaaatt
    23461 cacttataac tcaaaaccag tatgaaagag gagtattaag tatatttaga atgatattag
    23521 ccacttgtga taccttacta ataaatggac ttacactacc tctagttgaa tactttggaa
    23581 ataatttatc agcatggact aaaacattct ttgtatttgg aatagcatct ataatggtat
    23641 tttttataac atttactgga accaaggaaa gagtaaaagc agttaagcaa gataggaatg
    23701 aagtaatacc atttaaaata ggtattaaat ctttatttag aaataagtac tggatacaaa
    23761 taacattatg tttagtttgc atatttattg tatttgcgat aaatggtggt tcatccgtat
    23821 attatgcaaa gtttattttg ggagatgaaa aattatttgg tcctataaat atggtttcaa
    23881 atatatccca aattatagct atgtttatgg ttgctccttt tataaaaaaa tttggaaaaa
    23941 gaaatgtatt aatagtaggt tcaataatat taatatcgtc aaatgttatg tttataatag
    24001 ttggacaaaa tcatatagga gtaatatttg caagtgctat aaagggaata ggaagtgctg
    24061 gaatagcatc aacaatgttt gctattgttt cagatactat tgaatatgga gaatggaaga
    24121 ctggatatag aactgagggg cttataaata gtgcatctag ttttgggttt aaagtgggaa
    24181 atggattagg ttcagcaata ttaggtgcag tattatcaat tggtggttat gtaggaacat
    24241 cagctactca aagtgattta gctatagtat caataaaagt atgttttata tacctaccta
    24301 tatttataac aatattacaa attatcataa tgtcttttta taagcttgat aaagaatata
    24361 gtactatact taatgaatta aatactaaat aatgaaaaag tttcttataa agtcttaagt
    24421 ttaattaagg tctattgtaa atgttcccta taaaaactat tatatattta tgattattga
    24481 agaattttta gagaagcgaa taataaaaat ataagaagac tttaaatgat gaaatggttg
    24541 gttttttaga aatgatttaa taagttattg ttatttaaag cattataagt ggacaattaa
    24601 tttttaattt atggagatga tatttaacaa ttagaagtaa tatataatat gcactaagaa
    24661 gcaatttttc aactatttat gaaggtggtg gtacaagaaa agtatcacct tttttttgtt
    24721 atacaaaaaa acagttgact ttttatatga accccttcta taatgttact gaaattaagt
    24781 aaaatgattg aacaaatgta aagataattg aaaagcttga ttttggagga aagcaaatga
    24841 aaaaaattgg agacttaaga ttaatgatga agtgttgttc actttattac gaagataatt
    24901 tgaatcaaca ggaaatagca aatcaattgg gaatatcaag accaacaata tcaagaatat
    24961 taaaagaagc ttttgaacaa ggaatagtaa aaatacagat agttgatgtt ttgaaaaatg
    25021 attaccaaaa aatagagaga agtttggaga gaaaatataa attaaaagaa gtaatagtag
    25081 tagatgataa acaggatgca ctaacacaaa aacaagaact agcaagagct gtatctgaat
    25141 atttaactag agtagtaaag gaaaatgata taataggtgt ttcaatagga acaacactaa
    25201 aagaaatacc aagatatgtg gaaaaaagta actgtaaaaa tgttacattt atacctctat
    25261 taggagggat tggagacaat gaaatagata ttcatgcaaa tcaaatagcc gtaagtttag
    25321 cgagggcttt tggaggtgat tttaaattat tacatgctcc agctgttatg tctgacttgt
    25381 ctacaaaaga gaaactttgc aaagacgaaa aaattaaaga agtactagat ttaatagata
    25441 aaacaactat agcaattgtg ggtataggaa atcctatgag tttaaactca acaataatgg
    25501 cttctggata catgaatgaa gcagatatag aagatttaaa aaaatacaac tcaataggtg
    25561 caatttgttt acaagccttt gataaagaag gaaaaacttc tatacttgaa tttaatcaaa
    25621 gagtattagg agtgaaactg gaagatttaa aaaagataaa aagaacaata ggtgtcgctt
    25681 caggagatga aaaaatagag gcaataaagg catcattaaa agcgaaattt ataaatagtt
    25741 tagcaattaa tcacagttta gcacttaaat tattagaaga ttgtgactaa tagaaagata
    25801 gataaaagtt aacaggaggg aatgtatatg tcaatatcaa aagaaacatt gcttgaaatg
    25861 tataagagaa tgaatcaggc tagaaaattt gaagagaaag ttagttggtt ttttgcaaga
    25921 ggtatggttc atggaacaac tcacttatct gtaggtcaag aagcgtcaag tgtggcggct
    25981 gtaatggctt tagaaaaagg agatttagta tcattaactc atagaggaca tagtcaattt
    26041 ataggaatgg gaatagacct aaataaaatg atggctgaac ttatgggtaa agaaactgga
    26101 ttttgtaagg gaaaaggagg ctcaatgcat atagcagata ttgagtcagg taacttagga
    26161 gcaaatggag ttgtaggtgg aggtcttaca atagctccag gagctgcact tacacaacag
    26221 tataaaaaaa caggcaaaat agttttatgt agttttggtg atggagcatc aaatgaaggt
    26281 acttttcatg aaggaataaa tttatcttca atatggaaat tgccaataat attttactgt
    26341 gagaataatt tatacggtat gtcaacaagc ataaaacgtc atatgaatat agaaagtatt
    26401 gccactagag cagcttctta tggaatagaa ggaatatcaa tagatggata taacccaata
    26461 gaagtatacg aaacagtaca aaaagctgct gagaagtgta gaagaggaga aggacctgta
    26521 ttaattgaaa gtagaactta tagatggtta ggtcattcaa aatcagatgc aaatgtatat
    26581 agaacaaaag aagaaataga atcatggaaa gcaaaagacc ctattgaatt tttaaaaaat
    26641 tatcttatag aaaataatct atctaatgaa gatgaattag ataagattca agaatttgca
    26701 aagcaatcaa tagaagatgc agtagagttt gctcaaaata gcccaaatcc aaaaatagag
    26761 tctttattag aggatgtata tgcagactaa gaatggtaaa ggaggaaaat aaaaatgagt
    26821 acaagggaat taacatatgc acaagcaata aaggaagcaa tgtcagaaga aatgagaaga
    26881 gatgaaaatg taatatttat gggagaagat ataggaatat atggaggagc atttggtgta
    26941 tcagttggta tgatagatga atttggacca gaaagagtaa gggatactcc tatatcagaa
    27001 gcagctatag caggagcggc agcaggtgca gcagcaactg gcttaagacc tattatggaa
    27061 gtaatgttta tggactttgt aacaatttct atggatgcaa ttgtaaatca agcggcaaaa
    27121 atgagatata tgtttggagg aaaagcacaa gttccaatgg ttgttagatg cccaggaggt
    27181 tctggaactg gttcagcaga gcaacattca caaagtttag aagcttggtt ttgtcatgta
    27241 ccaggagtaa aagtagttgc accttctaca ccagcagatg ctaagggatt gttgaaagca
    27301 gctataagag ataataatcc agtcatattt gttgagaata aattgttata cagaaaaaaa
    27361 ggttttgtgc cagaagatga ttatgtaatt gaaattggaa aggcagatat taaaagagag
    27421 ggtactgatg ttacagtaat tacttatgga agaatgttac aaagtgttga agaagcagca
    27481 gagactctat caaaagaaaa tataaatgtt gaaattatag atttaagaac tttatatcca
    27541 ttagataaag agactatagt aaagagtgta tgtaaaactg ggagagtttt aatttgccat
    27601 gaagcagcta agactggtgg gctaggtgga gaaatatcag ccctgataac agaaagtgaa
    27661 tcatttgatt atttagatgc tccagtaaaa agaatttgtg gaaaagatgt gccaatacca
    27721 tataatccag agttagaaaa agcagttgtc ccaagagttg atgaaataga agaagcaata
    27781 aaatctttaa ttgttagata aggagggata gatatggtgg caaataaaat aaaagccaca
    27841 ccagcagcta gaagtcaggc aagaaaagac aatataaaat tagataggct gattggaagt
    27901 ggagaaaatg gaaggattca tttagtagat gtgttaaatt atttaaaaga taataaagca
    27961 aatactactc ctttagctag aagaatagca gaagatttaa atatagattt agaaactatt
    28021 gtaggtactg gatataatgg aaagataaga aagtgtgatg tggaaaaatt aactggaaaa
    28081 gaaactattg tatcaactaa tacatctaaa tctagtgaga aaaaagagct gaaaattgaa
    28141 aatgaaaatt caagaatgtt taacacagta gaaggaatat ttgaaaagcc aaatccaatg
    28201 agagctactg tagcaaaacg aatgtcagaa agttatttta gtgctcctgt atttacattc
    28261 aatatagaag tagatgctac agaattgaag gtacttagag caaagttaat cgacacagta
    28321 aaagaatcaa ctggagtaaa attaactatg acagatttaa tagtaatggc agtatctaaa
    28381 atacttccaa atcatcaagc cttaaattca gcatggacag atgagggtat atttagatat
    28441 aaagatgtaa atatagctat tgcagttggt ttagatgaag gcttatatgt tccggtagta
    28501 aaaaatgcaa acaaaaagtc tttaaaagaa atagcaaaag aaagcaaaga acttgcggaa
    28561 aaagtaaaga cagggaaact tatgccagca gaccaagaag gtaatacatt tacaataagt
    28621 aatgttggaa tgtatggtat aactacattt acacctataa taaatatgcc ttcaagtgca
    28681 atcttagggg taggtgctac acaagataag tttgttccag taaatggaga ggctaaaata
    28741 aaacctataa tgaacttatc attaacatca gaccatagag taatagatgg aacagtagct
    28801 gcaaaattct taaaagattt aaaagaattg ttagaaaatc ctttatcaat gcttgtatag
    28861 gttttgatat tttgttactg atataaatag tttgaataga ttatattatt ataattgttt
    28921 cagtaaattt aaagctttta tatattaaga attattttta acagtaacta tatgtgaata
    28981 tgatttgctt aattaaaata tatgaaaata aataggagga gagcctatgt cagtagaagt
    29041 aataatgcca aaagcaggag tagccatgga agaaggtact atagtatctt ggctaaagca
    29101 agaaggcgaa gaagtaaaga ttggagaacc tatactagaa ataacaacag ataaagttaa
    29161 tatggagata gagtcagaag gagaaggtac acttgctgta atcatacata aagaggaagg
    29221 tgaagtatta ccagtattta cagtaatagg tgtaatagca gaaaaagggg aaaatcaaga
    29281 ggaagtaaaa gctaaatatt tatctggaaa tgtttcaaaa gaagatatag ttgaagagaa
    29341 tcaaaatata gaatttaaag aagaaaaaat aaacaaaaaa gagtgtaatc atgattatga
    29401 tgtagtggta ataggaggag gacctggggg atatttatca gcattaaaag cagctctttt
    29461 aggtggaaga gttgctttag ttgaagaaaa tatactagga ggtacttgct taaatagagg
    29521 ttgtatccct acaaagactt atataaaaac agcagaaata ttagaagaaa ttgaccaatt
    29581 atcaaagaga ggtgtaaaag taactgtaga taaagaacag gacattaaga aggccataaa
    29641 atataaaaat agagtagtta aaaaacttac agctggtgtt ggcggattat taaaaagtag
    29701 agatgtagat gtgtttaatc ttaaagctag tgttaaagaa gagcataaag taattttatc
    29761 agatggaaaa gttttagata cagaaaatat aataattgct acaggttcca aagtaaggat
    29821 attacctata aaaggaatag aatcaaattt aataataact agtacagaag cattagattt
    29881 ggaaacagtg ccagaagaat tagtaataat tggtggtgga gtgattggtt gtgaatttgc
    29941 agagatattc aattcaagag gttctaaagt aactatagta gaaatggaag atagagtaat
    30001 cccaagaatg gataaagagt taagcgaatc tttaaaatat tctcttagta aaaaaggtat
    30061 aaatgtatta actaaaaaga aagtttctga atttaaagaa gaaggaaata acatattagt
    30121 gtgcattgaa ggtgaagagc caataaaagc agatttatgt ctatatgcta taggaagaga
    30181 agctaatctt tctggcatag aggacttaga tattaaaata gataaaggtt caatagttgt
    30241 aaatagtaaa atggaaacaa gtataccaag catatatgca gtaggtgatg ttactggagg
    30301 tgtaatgtta gctcatgctg cttttaaaat gggagaggta gcagcttcaa atgctctagg
    30361 tgtgaataaa gaagttgact taggtgcatt acctagttgt gtttatacaa ttccagaagt
    30421 agcatcagtt ggtattacag aagaggatgc tagaaaaaaa tataatgtaa aagttggtaa
    30481 gtttaatttt gctggaaatg gaagagcttt agcttctggt caagaacaag gatatgtgaa
    30541 ggtagtagca gatgctaaat atggagaaat tttaggtata catatgtttg gatgtggtgt
    30601 agcagaactt ataaatcatg cagcatcatt taaagcgtta gagataccta ctgatgaagc
    30661 aagtgagttg atatttggtc atccatgtac ttcagaagct ttaatggaag ctttggcaga
    30721 tgtaaatgga gaatgtttac acttacctaa aaaataaatc taaacataaa ttattaattt
    30781 aagtctatta ttaatattaa tttatatcat aaaattttaa aacacttact tagccatacc
    30841 ccttattatg caaataattt atttgcataa taaggggtat tttttatgga aaaatataga
    30901 atatagaatc cttgtagttt ttgttgtaca aaaaagatag taatataaaa taacattatc
    30961 attttagaat gatttcaatt gtaattagga aaagtgattt ttttgttttt aaaaaaagta
    31021 ttatttgtaa aatataaaaa aaaatttctt aatatttgaa taaaagaata gcttaattta
    31081 aatgttatta ctttataaaa aaataataag tacaaaaaaa acaatatatg gcatataagt
    31141 tgctatataa ataataagga gggaacaatt ataaatgagg caaagaataa aaaacttaat
    31201 tgaaaatgaa gataagaaaa atcctttaac agatgaagcg atttcaagta ggttaaatat
    31261 tcgaagagaa gatgttacct ttttgagaaa tgagttaaaa atagaagatt caagacaaag
    31321 aagaaaagtt gttttaatta aagctataaa agatatttta aaagaagaaa aaactataaa
    31381 taaaaatgat ataacaagaa gattaaacag cattgggttt acagtatcaa gatttacagt
    31441 catacaatac ttaaaagaga ttcaagattc tggtgaccta aaacttgata aagagagtga
    31501 tgataaaaaa gaagaaataa tcaataatag agaaaataaa gatatagcat ttgataaact
    31561 tataggtagt agtggtagct taagtacaat tataaaacta gccaaagcag caattcttta
    31621 tccacctcat ggtcttcata ctattattat ggggccaact ggtgttggaa agagtgagtt
    31681 agcagagtgt atgtataaat ttgcagtaga atcatccaga ttccctaaga atgcaccatt
    31741 tatagttttt aatgcagcag attattcaga gaatccacag cttttgctat cacagttatt
    31801 tggacacgtt aaaggtgctt ttacaggagc tgatgagaac aaagaaggat tagtatcaaa
    31861 ggcagatgga ggaatattgt ttatagatga aatacataga ttacctcatg aaggtcaaga
    31921 aatactattt caactgattg ataaaggtat ggtcagaaag ttaggagaaa caagactaac
    31981 acataaaata gatgtaatga ttatttcagc aacttctgag ccaatagatt ctcatttact
    32041 taatacattt aaaagacgta tacctgtaac aattgaaata ccagaattag ttgcaagacc
    32101 attaaatgag aggtttgaca ttataaataa tttcttctta atagaagctc aaagaatggg
    32161 agcaaacata catataaagt cagatgtatt aaaagctctt atgctttacg attgtatagg
    32221 taatgtaggt caacttagaa gtgatattca agtagcttgt gctaggggac tattaaacca
    32281 acttacaaac aaactaaaag aagtaaatat aagcatatca gatgtacctg gatatgtaaa
    32341 acaaggtctt ataaaaatca gaaattgtag agggaaaata gaaaattatg tagatgggga
    32401 tttaattata gactcaaatc ttcaaggtga gatagaaaag aaaaatgaag atatatatac
    32461 ttttccagat gaaatataca aacttactga aagaagacat attgatttat tggaacaagg
    32521 tttagatttt gatgttataa atagaatcat tggaggagaa ttagaaagtt gcattcaaaa
    32581 atacataaaa caagttaaaa aagtttctat tagtaacaat cttccagata taagtccaat
    32641 tgttggaaaa tatatcgtag agctaactta tgaagtaatc aaaatagcat cacaatacct
    32701 aagttcacta gaaccgaatc tacatttatg tttagcagtt cacctaaaag cagcttttga
    32761 gagattaaaa gaaggaaaag taatatcaaa tgctcatttg aaagaaataa taggaaatta
    32821 tccagtagaa tattctgtag cagaaaaggt agctcaatat ttaaaggaaa gatataacat
    32881 aaacttacca aaagaagaaa taggtataat agcaatatat tttaaaatga gtagtagaag
    32941 agatatgtct gaacaaaaaa agataggcgt acttcttatg gctcacggaa gagtagcatc
    33001 ttctgtatgt gaggttacaa ataaactatt aggaattaat cacgcaaggt atttagatat
    33061 gccatttgag aagaagccgg aagaaatgat tgaagaagct actacaataa taaaagatat
    33121 tgatgaaggt agaggtgtga ttatattagt agatatgggt tcactttcat attttggaga
    33181 tattatttct ggaaagactg gaattaatat aaggacaata tctagatttg atacattgct
    33241 ttctatagag gttatacgaa gagcagtttt accagattta acaatagacg agatagttga
    33301 tgaagttaaa ggtatagagc cacaagtaaa agaaaaggtt agtaaatgta acaatacaaa
    33361 agtagatttt agaaaaccta taattttaac attatgtatt actggattag ggggagcttg
    33421 taagataaaa aaaatcttag aggaaaatat taaaagtata actgaaaagg ttgatataga
    33481 acctataggt atgattgaat atccaagtct tgatttagag ataaaacaaa taagcaatga
    33541 taaaaatgta atcgccatag ttggaacaat tgaccctcag atagcaaata tccctttttt
    33601 tagtctagta gacataaatg ataaagcgaa gttaaatcaa ataaataacc taattgatac
    33661 aaatcaaatt ggtgaaacaa ataaaaaata tgaattatca gatttaatac ataaagaaga
    33721 tatatttgtg gatttacagg ttaaatcaaa agaagaagtt ctaaaatata tgagtaaaaa
    33781 acttagagag aaaggttatg tgacaaaaaa tttctataaa aaagtagtgg aaagagataa
    33841 cttatttcca actgaattat cagatgaaat agcaatacct cacacagatg gaatagatgt
    33901 aattaggcca gctataagta tagccatctt aaagaagcct attgtgtgga gtaaaagtaa
    33961 agtaaaaata atacttttat tagctgtaga ccaaaagtgt tttaatccat taagcactct
    34021 actctcattt atagaaacag atgaatttaa gaagataaaa aacattaaag atagagattt
    34081 tattagggag atgatattag atggagtcaa tgaaaataat tagtagcaat ttaattttta
    34141 aaaatattga agtgtctaac aatgaagatg cattaaagtt tttgggacaa cgtttgtttg
    34201 acgaacagta tgtaaaagaa agttacatac aagctgttgt agcaagagaa aaaaagtatg
    34261 ctacagggtt accaacagaa atatacggag tggcaatacc acatacagat atagtacatg
    34321 taaatgagcc aggaatagca attggaatac tgaataaacc tgtaaaattt ataatgatgg
    34381 gtacagacga tactgaaatt gatgtaaaag ttgtatttat gttagcagtg aaagagccac
    34441 aagaacaatt gcaactatta gaaaaactta tgactatatt tcaagataag aatatactaa
    34501 ataatattgt tgacttaagt gaagaaagtg tgagtgattt attaaactct aaattgaaaa
    34561 attaaacatg taaagtatat taaaaatgta aaattaaaca tgcaaagtat gttaaaaaat
    34621 ataaaaagat tattaaagat ttctaactat agatatcttt aaaataaaat aatttcaatg
    34681 ggggtgacta atgtggctaa aaagatatta gttgcatgtg gaacaggagt atgtacttca
    34741 acaattgcta taaacaaatt aaagaaagca cttcaagaca ttggtaaatt ggatatggtt
    34801 aatattacac aatgtaaagt agtagaagtt gcatcaaaag cacctgatta tgatttaata
    34861 atttgtacta cacaagtatc tagtagtata aaaacaccag tgataaatgg attacctttt
    34921 ttaactggtg tcggaatgga taaattaatc aatgatgtat tagaagagtt agaattataa
    34981 ttaaaaaaat taaggaacat ggtctctaaa atcataagtt ttagagactt aaaattaaat
    35041 aatggagggt ctttatatgg agatattaaa tttcattgtt ggtctaggtg cacaagtaat
    35101 gatgccaata ataatatgta tttttggttt gatattaggt acaaaactag gaaaatcttt
    35161 aagagctggt ttaactgtgg gagttgggtt tataggtctt aacactatta tagctttgct
    35221 aacagataat ttaggtccag ctacacaaca aatggttaag aatttagggc taagtttatc
    35281 aataatagat gtaggatggc cagcagcatc agctatagct tttgcatcaa cagtaggggc
    35341 tttaattatt ccaataggtc ttgtggtaaa tatagttatg ctaattacta atactactca
    35401 aactgttgat gtagacatat gggattactg gcattttgct tttacaggag ctttagtggc
    35461 aggtgctact caaagtgtaa tgtggggagt atttgcatca gtagcaaata tggtaattgt
    35521 attggtaatg gcagatttaa ctgctccagg tatagaggaa tatttaggta tgccaggtat
    35581 atctcttcct catggattta cacaggcatt tgttccaatt gctatagtag taaataaatt
    35641 attagaccta ataccaggta taaataagat tgagataaat gctgatacat tgcagaaaaa
    35701 atttggatta tttggagaac ctttaataat ggggtctgta ataggtgtaa taattggtat
    35761 tgctgcgaaa tatgatataa aaggaatatt acaattaggt gtaactatgg gagctgtatt
    35821 aatattaatt ccaaagatgg cagcattatt aatggaagga ttattaccag tatcagaagc
    35881 tgcacaggaa tttattgaga agagatttaa aaacagaggc aagatttata taggcttaga
    35941 ttcagcagta ggaataggtc atcctgttac attatcagtt gcactagtgt tggttccttt
    36001 gactatactt atagcagcta tattgccagg aaataaagtt ttaccatttg cagatttagc
    36061 agtaattcca tttgcacttg tattaatcgt accaattaca aagggaaatg tgtttagaac
    36121 attaataata ggaataatta taattacttc tggattatta atcgcaacta acttagctcc
    36181 attatttacc caaatggctt taaatgctag ttttaaaatg cctgaaggag caactatgat
    36241 ttcaagtatt tgtgatggtg cgaatccatt aagttgggta tttgtaaaag ttatgaacta
    36301 taaagttatt ggaggagtag tttttggagt tatagcttta ggaatggcta tttacaatag
    36361 gaatagaata ataaatgaaa ataaaaagct atctatagaa gaataaggtt aaaacaattt
    36421 tattaaggag tgtataggtt atgaaaaaat ataaatatga ttctaaaaga tacttactca
    36481 gtgttacaat accaggat
//
LOCUS       DAEPID010000038        36257 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.038, whole genome shotgun sequence.
ACCESSION   DAEPID010000038 DAEPID010000000
VERSION     DAEPID010000038.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 36257)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 36257)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..36257
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.038"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            <1..334
                     /locus_tag="KR257_002071"
     CDS             <1..334
                     /locus_tag="KR257_002071"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434052.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=2
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBH0030757.1"
                     /translation="LDFEIQFIIVSICLIVSFSMFVALMGLLSNLLYPNLDWKNEVAV
                     VKRSASMIVTMLVSLAYVIILGGIYVLLGISFLNIYIILASILTLILDFMIWRIISTK
                     GVRIFKNL"
     gene            437..1519
                     /locus_tag="KR257_002072"
     CDS             437..1519
                     /locus_tag="KR257_002072"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424437.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flippase-like domain-containing protein"
                     /protein_id="HBH0030758.1"
                     /translation="MRKLSKREKDFIQYGFLLFLICITTYLVLTTLDIKLIPKIIRLV
                     NKTYIFLGILTIIVYMIIESIVTHLIINAVQKTKVKFIGIKMATMGFYYNLVTPFASG
                     SQPMQIYALTKYDVSLSKSVAIVTNKTVVFQSTVTVFCGILILLNKSLLMEQVHSVKV
                     LITFGMIMNVSMLLGGLLIVFSPKQVKMIAEVLINFLSKFKTFKFLDSKRDRINHYID
                     DYNYSIKIFIKNVRILVLSILLTVLQLIAYFSIVYCVYKASNLRGVSYVHIMTLQVFL
                     YMAISPIPTPGNVGANEVTFFTMFSNIIPKELLGYSVLLYSGFVYYFILIVSGLFTFG
                     THYTLNSWKKENKVNSNLDKVIEKLN"
     gene            1668..1829
                     /locus_tag="KR257_002073"
     CDS             1668..1829
                     /locus_tag="KR257_002073"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009905751.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA polymerase III"
                     /protein_id="HBH0030759.1"
                     /translation="MKQDKQNEKQSEISKIKQSNDNKLEIAQELHVSKNIGNMLGYRI
                     DKKKMNRPS"
     gene            2170..3438
                     /locus_tag="KR257_002074"
     CDS             2170..3438
                     /locus_tag="KR257_002074"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003433135.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cation:proton antiporter"
                     /protein_id="HBH0030760.1"
                     /translation="MEASIHTIASNNLLIIFAIVSITGIICSKLSEIIKVPDVVLYLL
                     VGILIGPSFLKFIDIRGFQIENQLILTFGSAFILYLGGKEISLKVLRNVKISVFLLAT
                     LGVVISAFIMQQVIGFTFGISAMTALLAGTIIASTDPATLVPIFNQVKIKDRVKQTVI
                     SESAFNDATGAILTSAVLAVILSNKFSLGENIYELGTMVIVGVLVGLITGILLLKLVN
                     DKPYGIFKDFAPIISVISVVVAYELSTKLGGSGYMSCFIVGIITGNKKNFKIWLSQKS
                     YDADFYVAETLGTICRMAIFIILGSQVNLAQLSKYFMPSVITVLVLMFIARPLCVLVC
                     TLVDREAKWSKSEILFMMWVRETGVIPAALCGIISAMKVPGYEVISSVVFMTILITLV
                     IQGSTTKLVAKKLGLLEEEVINISEKVSTF"
     gene            3633..4421
                     /locus_tag="KR257_002075"
     CDS             3633..4421
                     /locus_tag="KR257_002075"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424428.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="FAD binding domain-containing protein"
                     /protein_id="HBH0030761.1"
                     /translation="MFTVMDIVQPDTVEEAYSILNKRKTNQVIGGSAFLRMGKKRIGT
                     GIELSKLNLDYIKEYEDYVEIGSMTTFRTLETSSIIKNNFGRIIEDSVKNIIGVQFRN
                     VVTVGATVFSKYGFSDLIVALLSLDTEVELYNIGRISLEEFLNRDYEKDLLIKIYIKK
                     TNKNASYKSLRNAKSDYPILNVSVSKHMEQFKLCVGARPQKATIAKQASEFLSNNEIN
                     EINIDKAVEIASEELTFGSNMRASREYRKAMSKVLLKRAIMEVI"
     gene            4421..4870
                     /locus_tag="KR257_002076"
     CDS             4421..4870
                     /locus_tag="KR257_002076"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434060.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="2Fe-2S iron-sulfur cluster binding
                     domain-containing protein"
                     /protein_id="HBH0030762.1"
                     /translation="MLVKININGKKKSVDIEPEEYLVDTLRKVGNLSVKRGCDTGCCG
                     LCTVLIDKKPTLSCATLTLRALDKEITTIEGLENEVKEFSEVLVKEGAEQCGFCSPGF
                     ILTVLAMKDELENPTDDEIKHYLTGNLCRCTGYMGQLRAIKTYLEVK"
     gene            4874..7138
                     /locus_tag="KR257_002077"
     CDS             4874..7138
                     /locus_tag="KR257_002077"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430642.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="molybdopterin-dependent oxidoreductase"
                     /protein_id="HBH0030763.1"
                     /translation="MNIVGKGIKKIDGMSITTGKPVYTDDLSAKDALVVKILRSPHAY
                     AKIKDIDTSKAEMVDGVECVLTYKDVPKSRFTLAGQTYPEPSPYDRLILEDVVRYVGD
                     EVAIVAAIDEKTAIKAMNLIKVKYEVLTPVLDFEEAIGNKTMVHDEDRHCNFDIGMQR
                     EKNIVSHHDYTKGDVEKVLSNCDVVIEETYYTQAQAHAMMETYRAYNYLDHMGRLVVV
                     SSTQIPFHVKRHLSRALEIPASKIRVIKPRIGGGFGGKQTACVEIFSAIVTLKTGKPA
                     KIIYDRKETFNCSTSRHAMRLKVRLGATNDGIIKAIDIKALSDTGAYGEHASTTIGLV
                     GEKTLPMYNKVEATRFIADVVYTNKMPAGALRGYGASQGCFAVESTINMLANKLKMDP
                     TDLRLKNVVTEGETTFAYGKTLNSVDLIKCINKGKELIGWNEKYPCKHLDNGKIRSVG
                     MAITMQGSGIQGLDKSSAEIKLNDCGDYTLMIGSTDMGTGSDTILAQMAAEVLDTSIE
                     NITVISADTDLVPYDPGSYASSTTYVTGMAVVKAAQDLREKIISAGATKLGVEKDEVK
                     FDGIKLTSKKGSTLLFDIAVDSTIGPDTNQLIGLASHGSPVSPPPFIAGFAETEIDTE
                     TGKVDLVNYVAVVDCGTVINKNLAKIQVEGGIVQGIGMALFEEVRYTEKGRMDTNTFM
                     QYKIPARCDIGNVKVDFVETYEPTGPFGAKSVGEVVINTPLPAIQEAVFNGIGVRINT
                     LPITPEKVFMEMNK"
     gene            7278..7589
                     /locus_tag="KR257_002078"
     CDS             7278..7589
                     /locus_tag="KR257_002078"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003433131.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0030764.1"
                     /translation="MAGNLNNMRAVNNFRGDKNILECLVSFEGRSISQRKVRVFFKEK
                     QNQIEIDFAEEEISKLVENVVLNTSYQEMLYDEIEKQLEIDCIGTWMILSKLKDGSRV
                     H"
     gene            7875..8375
                     /locus_tag="KR257_002079"
     CDS             7875..8375
                     /locus_tag="KR257_002079"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424418.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="QueT transporter family protein"
                     /protein_id="HBH0030765.1"
                     /translation="MRKNSINIALTAAITAIYAVLTLSLGFISYGPIQFRVAEIMMLL
                     AFLDKGYIVGLTLGCFLANVIGPYGVPDIIFGTLATFISASMIYITRKLGKQNKSTLV
                     IASLWPTVINSIVVGLMLNVFFGLPLILSMIQVGFGEFVVVTIVGVPFFCFLMKKYKN
                     VINIKF"
     gene            8432..9418
                     /locus_tag="KR257_002080"
     CDS             8432..9418
                     /locus_tag="KR257_002080"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893441.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="WYL domain-containing protein"
                     /protein_id="HBH0030766.1"
                     /translation="MSKVKRLTDVWIYINDKQKFTIKELSEEFNLSAKTIQRYLKELN
                     KMGLPIQAEQGRNGGYRVLNNSYIPPVIFTEKEVMIILFALKSLQIYNYKLMEIEINS
                     IMRKVSYERKSSIKVGIENIKRYIGFVANDTNDGDFKSSNVTEFFRASSESLILNIKY
                     KCGNQILEKNVCPIGIYLNKGAWFSPAYDCKSDKIILVHIDNIIDIKRTGESKKIHIN
                     LEEWLHEVYNNLYGNSSTTKKFGEIIYLNVLLTKEGVSKIKDSSWNLDMELNEDGSGI
                     ISTFIKVEDIDCYASILFFIGNNAKVIEPKFLNKLLYDKANELRYFYEENMV"
     gene            9468..10190
                     /locus_tag="KR257_002081"
     CDS             9468..10190
                     /locus_tag="KR257_002081"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424413.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell division protein"
                     /protein_id="HBH0030767.1"
                     /translation="MENFNKNAKIIGIGAEGINIINEVEEKIKANMDIEKININQEIE
                     KEYVRSLLDGVDILFLIYSSEDKHIRDIIKAVSYMSNERRVLSIGMDCSEKENKEDLE
                     LGREFKINNDSIFKFVDLMNIMVESISDSCMINIDITDLKEAIVGDKGIKYSFEEFED
                     TKSYSEIADILFDRMEYIGEEFISKKGIVFVEGSPEFSIMELNDLISNIQSKVEESYE
                     VIFSLYIKENLNGNIRVGLLYN"
     gene            10219..12153
                     /locus_tag="KR257_002082"
     CDS             10219..12153
                     /locus_tag="KR257_002082"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893437.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AAA family ATPase"
                     /protein_id="HBH0030768.1"
                     /translation="MSENIRGTEYWLMEEFFYQETDTPQIFREESIIALGFDIKINLK
                     KVFSMGKKSEKYINENCNDKDFIKKFMSIKKGDYFLYKAYQNIEEKVKCNVSIGIVEE
                     DFENGYELSHILGHTLPVKWMHNFDTVSNCKVYTSEFYKLNNNDISSYLEIIKSQDKK
                     LLRKRIEESENNKWYLKNYYYKNVDKCVDDEELFIQPINLEQLESLKNIKTDDYILLY
                     NSEKVICENDHTMKSLFGVCQVMEGFDKEKVSALEGGYFFPVRWIEYEKENIDGNAWV
                     IFENNSIVEKYVKRFTNKMPLNTILYGPPGTGKTYNTKQMVYNLVSETSLRNKYYTGY
                     LDYKNNVEFCTFHQSYGYEEFIEGLKSDGEGNFKQEDGILKDISIEACYNALKFEKKM
                     SFELEKDSLTLETIKDRKKKLVLENIEYSESFNFEESENYVLIIDEINRGNVSKIFGE
                     LITLLEDDKRLTKSNQTIVKLPYSKEKFSLPPNLYIVGTMNTSDKSIALLDIALRRRF
                     NFEEIMPDYDLLSIVDGIDIRKMLYTINKRIEFLYDRDHVIGQAYLLAVENINDIVVV
                     FRSKIIPLLQEYFYYDSEKVGLILGGIGRNEKDKYIVYKEKLIASELFKNNNASIMES
                     KVNYCIKQNISSEELKNIYE"
     gene            12146..13414
                     /locus_tag="KR257_002083"
     CDS             12146..13414
                     /locus_tag="KR257_002083"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018112798.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="McrC family protein"
                     /protein_id="HBH0030769.1"
                     /translation="MSKNIYVKETYEWIRVGNGENELTEIEYEKLLKYLENNNDVLKS
                     NIIDIKYKKLRFINYVGIICFENVILEILPKLSLSDNLVKDREILLQMLSICNKIPIT
                     MNEKIRLSLKNYNLLNFFVMYFIESMQTQMKKGIYFEYINKIENLNVMRGKILLSTYA
                     KEKGISPMKIRCEYDEYSENNFLNQVLKKACISILCRINDNSIQGKIKKILSYFQNVD
                     LIYIDRKKLLDYKFYKNNDRFKDCYLLARLILLNLSMDNSQNNQEAFSILFEINTLYE
                     EYIGILIKSIWDNSFRETYIQDKSKFLLKNEQTGKKNFNLRPDIVLYDLKNEYEIIID
                     TKWKAIEVDSNVFYRSSDIYQMYAYITAYENAKRCILLYPCIQKDKNYSSWKLSESFK
                     GKFIEAKTVRLDDIKNTKNDLKKIIFNYKF"
     gene            13741..14781
                     /locus_tag="KR257_002084"
     CDS             13741..14781
                     /locus_tag="KR257_002084"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424403.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sigma 54-interacting transcriptional regulator"
                     /protein_id="HBH0030770.1"
                     /translation="MDKHSDSVMYGGMEVYNIWGTTTVDSIIGESDVMRALKNRICKI
                     GNSDSTVAITGESGTGKELIARAIHLAGNRGNKTFVAINCAAIPEPLLESELFGYTKG
                     AFSGADSKGKIGKFELANGGVVFLDEIGDMPIQLQSKLLRVLQEKKFTRIGSNELIDI
                     DVRIISATNRDLFELVKENKFREDLYYRLNVIPLEVPPLRERGDDIQILINNFIDKYS
                     RKMKKNVYHIEPDVEQMLLKYPWPGNIRELENTIELALNLLEEDGIIHKGIINRKILE
                     YFKLNNINIKLLEESDYEISMEQDILTLEEFERAYIKKVLKFYGNDTKSKKLAAKKLG
                     ISLATLYRKIDV"
     gene            15137..16459
                     /locus_tag="KR257_002085"
     CDS             15137..16459
                     /locus_tag="KR257_002085"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430656.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="purine permease"
                     /protein_id="HBH0030771.1"
                     /translation="MFDIDGRPPILKCLPLSMQHILAMIVGTVTVPIVVGGAVGVSPT
                     QITLLVQYALIIAGISTLIQLYPIGNIGSRLPIIFGVGFTYVPTLVAVGGNYGLASIL
                     GAQLIGGVATVLIGIFIKKIRKFFPNIVAGTVVFTIGLSLYPIAINYMAGGVNSPTYA
                     SMQNWAVAAITLVVVIGLSQFAKGYAKLAAIFLGIIVGYCVSLVLGIINFDPIREATW
                     FAIPKPLEFGMEFDMPVIISVVIVSIINAVQAIGDLSATTMGGMDRNITDKELSSGVI
                     GSGICTMIGALFGGLPPSSYSQNVGMVAMNKVISRFVLGIAGIFMLLSGFVPKFGALM
                     TTIPYSVLGGATISIFSIITMTGIKLIITEELSSRNITIVGLAIALGMGITSVPAAQE
                     AFPSFVKLVFGESPIVIATLVAFVLNLIIPNKSLEDEAKERAVMEETN"
     gene            16756..18117
                     /locus_tag="KR257_002086"
     CDS             16756..18117
                     /locus_tag="KR257_002086"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729126.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="purine/pyrimidine permease"
                     /protein_id="HBH0030772.1"
                     /translation="MKTRNTSKYDVDGIPPLKESIPLALQHLLAMIVGNMVPAILIAN
                     VVGLNQGQATMLIQGSMLAAGLATFLQLYPIPLFKGFKLGSRLPVMMGMSYVFLGACL
                     SVAAKDGLAALFGAQIAAGVIVFFVGFGVKKIRHIFTPIVSGTIIACMGLGLFATAIK
                     NLAGGEGTQTFGSPINFTVGVIVAFVIIMINKYGKGLVKNSSILIGILVGYAISLVLG
                     LVDFSAVQGAAIVSLPTPAAFGLEFRPELIVMFTIIYIIGIADMMGACTIATVGAMDR
                     EVTDEELASVVLGNSITSIISSLFAALPTGVFSQNTAIVSMNKVTSRFVIALGALVLL
                     LAGISPALGAIMTTIPSCVVGGATLVVFSSIAMSGFSIMSMDGFTEENNLIAGVSIAT
                     SMGLTTAPQVLDQFPETIGTVLGGSSIVSGAIIAILLQTLFKLKSRKSAENVTSNLEE
                     NIG"
     gene            18190..19584
                     /locus_tag="KR257_002087"
     CDS             18190..19584
                     /locus_tag="KR257_002087"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424392.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amidohydrolase"
                     /protein_id="HBH0030773.1"
                     /translation="MIDILIKNAIIVTVNKDRDVIFDGAIAIQGDRILDIGNTVDIEP
                     KYLDAKKVIDANGKVIFPGFINTHNHLFQVLLKGLGDDMALHEWLNTMMFPSAKFLTE
                     QDTYDAAMLGCMEGLKSGITTMVDYMHTHNRPGLTDGIVKAYKDLGIRGVVGRGCIDL
                     GIHKELIEDVETVEKDLRRVFEKYHNSENGRIKICVAPSSMWAISEEMGKMLWNIVKE
                     YDSYFTVHISETEFARTATKDIHGEIDIKLLEKWGIVGPEVVAVHCVCITDEDMEMLK
                     KYDIKVSHNVASNMYLASGVAPVPEMLKKGINVSLGLDGAASNNAQDMVELMKLTALQ
                     HKVNNCDPLAISAEKVLEMATIEGARTLRMEDEIGSLEIGKKADLVIFNSMLSPKSIP
                     LHNPVSTLVYSASMHNVESVLVDGNVILENGKVTTIESEEQVLLNAQHAAEELCKRAN
                     VTNRMEGHKWNSLY"
     gene            19646..20116
                     /locus_tag="KR257_002088"
     CDS             19646..20116
                     /locus_tag="KR257_002088"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434079.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="(2Fe-2S)-binding protein"
                     /protein_id="HBH0030774.1"
                     /translation="MEKIKLNINDYMYEIEVEKNETLLHVLREKLNLTGAKQGCNSGS
                     CGACKVLIDGVDMKSCKLLAKNCEGKVIYTIESFANGENLHPIQEAFIEVGAVQCGYC
                     TPGMIITTQALLNRNASPNEDEIREAFKENLCRCTGYVKIIEAVKLSAARLGGR"
     gene            20119..22335
                     /locus_tag="KR257_002089"
     CDS             20119..22335
                     /locus_tag="KR257_002089"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902994.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="molybdopterin-dependent oxidoreductase"
                     /protein_id="HBH0030775.1"
                     /translation="MEKVIGKSYPLKDAALKVTGQMKYVADMKPQNVLYAKMLLSPVA
                     HAKIKSIDTSEAEKVVGVRAIATYLNTSQRKYNGSLRFYEHKIPENEVIFSDTVRFVG
                     DRVAAVAAETPEIAEKAVKLIKVEYEELPAVFTIQDAIKEDAICIHGDSNIVSQNNIN
                     GGDVEKGFKECDYIFEDEYSTPAIHHSAIETHSVIAHYDYNDKLTVHTPCQNTFGFRI
                     ILSQIFGMSLNKVRVIRPAIGGSFGGKLELTIEPVAAALSKMTRRPVKMVLTRKESMI
                     STRTRHGSFVKLKTGVNKDGEVIAQDIKIYTNTGAYASSALNVIGALSHKVFKVYKIP
                     NIKFTGMPVYTNTPIAGAMRGYGSPQIFMAQQAQFAKIAKEIGMDLVDFQNKNAVEPD
                     DVDIIFHGSLGNPRVLDCIEQGKKMFKWDEKKKLPKEEGKYLRGIGMAIGAHGNGVFG
                     AHRDVVTLTLKLNEDGTLTLLTGAHDMGNGVVTMQTMMVAEVLGITPDKVDTFETDTD
                     ACTFNLGDYASRGVFVEGGGAKKTAEKLKNLILEEAEKLLETSKEDLYLDNGCVISKL
                     DENVKASLSDVAVYSQSKSLRELTVVEDYSSPAGRTSYGVHFAEVLVDKETKDIKVVD
                     FVAVHDVGRVINPLNLEGQLEGGIHMGLGYALSEELAFDEQGRPKATDFKTYKLFRTV
                     DMPKCQVAFVDGYEKAGPFGGKSIGECAVVPVAPAVANAVYNATDVEIHSLPIKLK"
     gene            22418..23089
                     /locus_tag="KR257_002090"
     CDS             22418..23089
                     /locus_tag="KR257_002090"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424384.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flavodoxin family protein"
                     /protein_id="HBH0030776.1"
                     /translation="MAKILGICGSPRKGATEYAVLEALKEAETIPGIETEYWSVRGKK
                     ISPCVHCDACIRKETMCIIKDDIQELEQKILEADGIIVGSPVYDMNITAQLTAVFNRL
                     RPMYLVHPGKLQNKVGAAITTGGTRYGGQELTKLPIINFFLMHEMLVSGGLGGCYIGG
                     TIWSKDGKAKGAQEDETGMDTVKRLGKGAAEAVMVSKFGLEKWNVVKEELDVKKDEKS
                     PLRDH"
     gene            23452..24666
                     /gene="dpaL"
                     /locus_tag="KR257_002091"
     CDS             23452..24666
                     /gene="dpaL"
                     /locus_tag="KR257_002091"
                     /EC_number="4.3.1.15"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890217.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="diaminopropionate ammonia-lyase"
                     /protein_id="HBH0030777.1"
                     /translation="MLKEIKWKVNNLPKGDKENCIKFLNEEEITKVRNFHKSFPQYKE
                     TPLANLEGLAKKLGVAGVYVKDESYRFGLNAFKVLGGSYSMGRYLAQRLDTDISELGY
                     DKLTSKEIKEKLGEITFFTATDGNHGRGVAWTANKLGQKSVVLMPKGSSEFRLNKIKG
                     EGADASITDLNYDDAVRLANDYAEADDHGVMVQDTAWDGYEEIPAWIMQGYGTMAQEA
                     IEQLKEYGVDRPTHVFVQAGVGSLAGAVQGYVASIYDECPITVVVEADEADCYYKSAE
                     AGDGKPRFVGGDMPTIMAGLACGEPNTIGFEVLKNHAAAFVSAPDWVSAKGMRTLGNP
                     LNGDEKVISGESGAVTTGLLVAAMEREDLADLRKDLKLDENSRILLISTEGDTDPDKY
                     RSIVWDGEYPSI"
     gene            24793..25980
                     /locus_tag="KR257_002092"
     CDS             24793..25980
                     /locus_tag="KR257_002092"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893427.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YgeY family selenium metabolism-linked
                     hydrolase"
                     /protein_id="HBH0030778.1"
                     /translation="MLNEQRKQEVTEICQKLIQNPSSSGNEEGVVKAIEESFEKLGFD
                     SWSRDRYGNIVGCIKGNKPGKKILFDGHIDTVPVPDASKWSVPPFEGKIVDGKIYGRG
                     TSDMKGQYTAMMSAVAYFAKDTNRDFAGELYVAGVVHEEIFEGVSAREISKAVQPDYV
                     VIGESSELNLKIGQRGRGEIVVETFGKPAHSANPEKGVNAVYKMANVIQKIQQLVPPT
                     HPVLGDGILVLTDIKSSPYPGASVVPDYCKATFDRRLLVGETREGVLAPIQALLDEMM
                     KEDPELNAKVSYAVEKADCYTGNTIESERFFPGWLYDEEDEFVQAAYKGLKEAGIDSE
                     ITQYSFCTNGSHYAGEAGIKTIGFGPSKENLAHTIDEYIEQEQLFIGTEGYYGILKSV
                     YGK"
     gene            26113..27483
                     /gene="hydA"
                     /locus_tag="KR257_002093"
     CDS             26113..27483
                     /gene="hydA"
                     /locus_tag="KR257_002093"
                     /EC_number="3.5.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424374.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dihydropyrimidinase"
                     /protein_id="HBH0030779.1"
                     /translation="MGTILRGGTIITSDKTYISDLRIEDEEIVEIGNNLEINGDKVID
                     ATGKIVIPGGIDTHTHFDMNAGSITTADNFETGTRAAIAGGTTTILDFAEANEGENLL
                     QGVEAYHKKASGNCYCDYGFHMTITCLNKDTFNHMEKLISDGIVSFKMYMAYDGMKVD
                     DGTIYRVLKKARDLGCIVGFHCENGDLLDVLIEENIQNGNLEPKYHPLTRPNIVEKES
                     VSRLADITKLSNSKSYVVHLSCRESLETVKMAREKNIDMIVETCPQYLLLEDNLYNKD
                     KFEGAKYVMSPPLRKKEDINYLWEGLSSGDIQTVGTDHCSFNFKGQKDLGIDDFSKIP
                     NGAPGVEHRLALLYTYGVLENRISANKFVEVTSTNAAKIFGMYPKKGEIAVGSDADIV
                     ILNINKEETISYKTQKQNVDYTPYEGFKVKCKVEDVFLRGNHVVQSCNVKEHPTGQYI
                     KRKITK"
     gene            27501..28907
                     /locus_tag="KR257_002094"
     CDS             27501..28907
                     /locus_tag="KR257_002094"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728530.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amidohydrolase"
                     /protein_id="HBH0030780.1"
                     /translation="MMDILIKNAIIVTVNKEREVIFDGALVVKDNKIADIGNSKEIES
                     KYTDVKKIIDAKGKVLFPGFINTHNHLFQTLLKGLGDDMVLKDWLETMTFPAANYLEP
                     KDTYDAAMLGCIEGLRSGITTMVDYMYPHSKPGLCDGIIDAYKELGIRGILGRGCMNT
                     GAQFGVHPGIMQDVETVEKDVRRLFEKHHNTENGRIKIGVAPAAIWSNSQEMLEMLWR
                     VVKEYDDALFTVHISETPFDREAAKELHGQYDIDVLEKLGILGPNVLMVHCVYLTEKD
                     MELTKKYDMKVSHNTASNMYLSSGVAPVPEMLKKGITVSLGVDGAASNNSQDMLELMK
                     LTALQHKVNKCDPLAMSAEKVLELATIDGARAIGMEDEIGSLEIGKKADLLIFNPMLS
                     PKAIPMHNPVSTLVYSSSMKNIESVIVDGNIIMEDSKILTANEEKALKDAQDTAERLC
                     VRGTIKNRMEGHKWNSLY"
     gene            28979..29425
                     /locus_tag="KR257_002095"
     CDS             28979..29425
                     /locus_tag="KR257_002095"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902988.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="2Fe-2S iron-sulfur cluster binding
                     domain-containing protein"
                     /protein_id="HBH0030781.1"
                     /translation="MIIKCTINNKEKELSIRPDDFLADTLRENGYVSVKKGCDTGSCG
                     LCTVMVNDKAVLSCNYLTARVEGQHITTLEGVLDEAKKFGDFLADEGADQCGFCAPGF
                     IMMVLAMKRELQNPTEEEVIDYVNGNLCRCTGYKGQLRAIHKYLNT"
     gene            29464..30258
                     /locus_tag="KR257_002096"
     CDS             29464..30258
                     /locus_tag="KR257_002096"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890208.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="FAD binding domain-containing protein"
                     /protein_id="HBH0030782.1"
                     /translation="MITIKEYVVPKSLDEAYELLISRKNNIILGGCGFLKLGSKNIGS
                     AIDLKDLALDYINETDDSILIGADTSLRTLELNKVIKNYCNGVISNAVSNIVGVQFRS
                     GARVGASVFAKYGFSDLIPSLLVVDAKVKLYKKGVMNLADFLENELEKDILIEVILPK
                     KDAIGVFDSIRKCTGDFAVLNGAMLKEGSIYKIAIGARPRRAKIAYKASEILSLENDI
                     EKAGEVSSEELSFGSNIRGSKEYRKDMAKALVVRMYNSIGGECDGK"
     gene            30248..32539
                     /locus_tag="KR257_002097"
     CDS             30248..32539
                     /locus_tag="KR257_002097"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890206.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="molybdopterin-dependent oxidoreductase"
                     /protein_id="HBH0030783.1"
                     /translation="MVNKEVRKIDSEAIVTGKPIYTEDLIFHKDVLTIKLLRSPHAFA
                     KIKNIDIKNALKVKGVVNIFTYKDVPNYRYSMVGESYPEASPHDQLILEDVVRYVGDE
                     VAIIAAEDERAAIKAMKLIKVEYEVMTPILDARESEGNKILIHEEDDLFCPFDFGLDA
                     TKNIVSREKMGKGDVEKEFKESDVIVEHSYMTQSQAHCMMETHRAYTYIDTNGRLVVT
                     SANQSAYHMRRQVSKALGIPLSKVRVIKPRIGGGFGGKNIAVTEIYASFVTWMTKRPA
                     KLIYTREETFAMTNTRHQMFFDIKIGSDKEGNIKAIDMKALNNTGAYGDNGPSVCSES
                     GHNVLPTYNNVPAIKFDGRTVYTNLVPGGALRGYGATQGTFALDCAIDELAHKLNMDP
                     TEIKLKNIIKKQTEGGIMNFPIRSCALDECIIRGKKLIGWDEKYPVRDIGNNKVRAVG
                     MSVGTHGSGIANIDMAIVNMRMDEDGTYKLFSGSSDLGTGSDTILAQIAAKALNTSID
                     RISVYTGDTDMCPYDTGAYASCTTYVTGNATIKSAESLKQKILKVAQKKLDLPIDDLI
                     LYEDRVCYSEDVEKFVLLSELGKESVGGGNQEVLYSSESYGIQESAKPFLAGFAEIEL
                     DKTTGEFKVINYACSTDCGTVMNPALARIQVEGGVTQGIGLAMYEDPRHGSDGKLQTS
                     NLLQYKVPTKKDIGNIIVDFVDNYEPTGPYGAKSLGEIVIHTPAPAIANAIYNATGVR
                     IRELPITSEKVYMAMKKLNQGGK"
     gene            32540..33853
                     /locus_tag="KR257_002098"
     CDS             32540..33853
                     /locus_tag="KR257_002098"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890204.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amidohydrolase family protein"
                     /protein_id="HBH0030784.1"
                     /translation="MIAIKSKYLISSADEIYTNSAVVVENDIIKDILPNEEVEIKYKN
                     IEEIIDKSDAIIMPGFVNGHMHQYGVLSRGIPANVHFTDFEGFLNDYWWPFIENRIGL
                     KEVKATTKASAIELIESGVVAFCDTLEAPNTEEGTLIEQGKILEEIGMKAILSLESCE
                     RISFENGLRCLNENSNLIKWSRENSKLINGIMCTHTSFTCSDRFIKKAKEDTKKLNAP
                     MQFHLCESIYEPNYAEKHFGKKAVDYYNDLDILDETVLASQCVKVNDEEIDILKEKGV
                     KVVHMPLSNCEVGGGFSPVPKMIKKGIKVALGTDGYINDFFEVMRGAFLMHKSVEEDA
                     SVMPANLVFRMATEHGAYVLGLQNSGKIAVGNKADIIVMEDEFKTPVTLDNIFDQIVV
                     QGKKEFISNVYIDGRHILKEKQLVDLDKKAIVKEMKEVACEFWKF"
     gene            33889..34974
                     /locus_tag="KR257_002099"
     CDS             33889..34974
                     /locus_tag="KR257_002099"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902986.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dihydroorotate dehydrogenase"
                     /protein_id="HBH0030785.1"
                     /translation="MYNFLGKELKSPLIIGSGPLTYSAAGCKILSDAGAGAVVTKTIR
                     KERAINPAPHMVRNTANALLNNEKWTDFEPEQWIDFEIPQMKRDGTVCIASVGHTIEE
                     SSELVEKVANAGADFIELVSYDYRDLIPMLKDAKERVNIPVIVKLPPMIDEIGDFAKK
                     LEEAGADAITACDSVGPAFRIDIETGQPLLGGNGIGYLSGETIKPITLQRIYEIKKQV
                     NIPIIGLGGCVSGDDALEMIMAGADFVGICSVVILKGAQVISKIHDDLKSNLNRLGYN
                     TIENACGIVHNHMGDVNERLSFEFTYDEEKCTKCKMCERVCAYQARKLNDKMELNEEE
                     CRYCGLCISVCKPKALGRKISCSELNV"
     gene            35204..36211
                     /locus_tag="KR257_002100"
     CDS             35204..36211
                     /locus_tag="KR257_002100"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012816238.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0030786.1"
                     /translation="MVMQVQEKILELLYTINEDVVSIKNDMSEVKQEINVLKEDMSEV
                     KQEMTVMKEDMSEVKQEINVLKGDMSEVKQEMTVMKEDMSEVKQEITVMKEDMSEVKQ
                     EINVLKEDMSEVKQEMTVMKEDMSEVRQEINIMKEDMSEVRQEINTMKEDMSEVRQEM
                     TVMKEDMSEVRQEMTVMKEDTSEVKQEINVMKKDMSEVRQEITVMKEDVSEVKSEVNF
                     MQNKINNINEDMNGIKDEVSIANEKLYGIEIKIDSLECEDKSMKEIQIEQNNILGSLL
                     HNSEINKATHDNIEHNIAYIKGDTNSIKEDIAEIRRDLNLVELATSKNWSDIVKLKSV
                     K"
BASE COUNT        14275 a         3734 c         6979 g        11269 t
ORIGIN      
        1 attagacttt gaaattcagt ttattattgt atcaatctgt ttgattgtaa gtttttcaat
       61 gtttgtagca ttgatgggat tattatcaaa tttattatac ccaaaccttg attggaaaaa
      121 tgaggtggct gtagtaaaaa gaagtgcaag tatgatagtt acaatgttag tatcattagc
      181 ttatgtaatt atacttggag gtatatatgt attacttgga atttcgtttt taaatatata
      241 tattattttg gcaagtatac ttactttgat attagatttt atgatatgga gaattatttc
      301 tactaaagga gtaagaatat ttaaaaattt ataggtgtat ttatgtcaaa taaagactta
      361 tcttttttag tcttgcaaat aataggttaa gtagtatact atgtatagtg atatgaaaaa
      421 atttaggaga aaataaatga gaaaattatc caaaagagaa aaagatttta ttcaatatgg
      481 atttttatta tttttgatat gtattactac ttatttagta ttaactactt tagatataaa
      541 actaatacct aaaattataa ggctagtaaa taagacttat atatttcttg gcatattgac
      601 aattatagta tatatgataa ttgaatctat tgtaactcat ttgataataa atgcagttca
      661 aaaaacaaaa gtaaaattta ttggtattaa aatggctaca atgggatttt actataactt
      721 agttactcca tttgcatctg ggagtcaacc aatgcaaata tatgcactta caaaatatga
      781 tgtaagcctt agtaaatcag tggctatagt tactaataaa actgtagtat ttcaaagtac
      841 agttactgta ttttgtggaa ttttaatttt gctaaataag tcattactga tggagcaagt
      901 acattctgtg aaagtcttga taacttttgg aatgattatg aatgtaagta tgttgttagg
      961 tggactacta atagtattta gtccaaaaca agtaaaaatg atagcagaag ttttgattaa
     1021 ttttttatct aaatttaaaa catttaaatt tttagattca aaacgtgata gaataaatca
     1081 ttatattgat gattataatt attctataaa aatatttatt aaaaatgtaa gaatcttagt
     1141 tttaagtata ttacttactg tgttacaatt aatcgcatat ttcagtatag tttattgtgt
     1201 gtataaagcc tcaaatttaa gaggagtttc atatgtacat ataatgacat tacaggtctt
     1261 tttatatatg gctatatcac caattccaac accaggaaat gttggagcta atgaggttac
     1321 attttttact atgttctcca atataattcc aaaagaatta ttggggtact ctgtactctt
     1381 atatagtggg tttgtatact attttatatt aatagtttca ggtttattta catttggaac
     1441 gcattataca ttaaattctt ggaaaaagga aaataaagta aattctaatt tagataaggt
     1501 tattgaaaaa ttaaattaat aaaataatta gggaaattct atatataaat atggtgttga
     1561 ataagctata ttatattgag atatttccct tttttgatta aaattataga aatttgaaat
     1621 aataagtaat aaacagaaaa agtgatattg ttttgaaagg agaaactatg aaacaagata
     1681 aacaaaatga aaaacaaagt gagatttcta agataaaaca aagcaatgat aataaacttg
     1741 aaatagctca agaattacat gtaagtaaaa atatagggaa tatgcttgga tatagaatag
     1801 ataagaaaaa aatgaataga ccaagttaat gaaaatgttg aaaatggtac attttaaaaa
     1861 atatatataa tgaaatgttt tattgttaaa tttaaactta ttttaatggg ggaaaaagtc
     1921 gaaaaatatc taaaaagata tggatataaa aaatattaat atatatatac tataaacttg
     1981 acaaaatcaa ccttttaata actagcaaaa aatagcaaaa ttatataagc gttatttaat
     2041 tgtcaaaaat gaaagctaaa ttgcatgtcc taaaaaaaat gattgataac atttatttgt
     2101 gtgctataat tatatagtaa aacaataagt atattgcata atgtatgcaa atcgggagga
     2161 gagacggaca tggaagcatc tatacacaca attgccagca ataatttatt gataattttt
     2221 gctattgtaa gtataactgg aataatttgt agtaagctta gtgaaataat aaaggttcca
     2281 gatgtagtgt tatatttact tgtaggtatt ttaataggac catcattttt aaaatttata
     2341 gatattcgtg gatttcaaat agaaaatcaa ctaatactta catttggttc tgcatttatt
     2401 ttatatttag gtggaaaaga aataagttta aaagtattga gaaatgtgaa gatatctgta
     2461 ttcttattag ctactttagg agttgtgata tctgctttta taatgcaaca agtaatagga
     2521 tttacttttg ggataagtgc aatgactgct ttactagcag gaactataat agcatcaaca
     2581 gacccagcca ctcttgtacc tatatttaat caggtaaaga taaaggatag ggtaaaacaa
     2641 actgtaataa gtgaatcagc ttttaatgat gcaacaggag ctatactaac atcagcagtg
     2701 ttggctgtaa ttttgtcaaa taaattttca ttaggtgaaa atatttatga actggggaca
     2761 atggttattg tcggagtttt agttggttta attacaggaa tactgctttt gaaattagtt
     2821 aatgataaac cttatggaat atttaaagat tttgcaccaa taatatctgt tatttcagtt
     2881 gtagttgcat atgaattatc tacaaaatta ggtggaagtg gatatatgtc ttgctttatt
     2941 gtaggtataa taactggtaa caagaaaaac tttaaaattt ggttaagtca aaaatcttat
     3001 gatgcagatt tttatgttgc tgaaacttta ggtactattt gtcgtatggc aatatttata
     3061 atattgggta gccaagttaa tttggctcag ttaagtaaat attttatgcc atctgtaatt
     3121 acagtattag tattaatgtt tatagcaaga ccactttgcg ttttagtttg tacacttgta
     3181 gacagggaag caaaatggag taaaagtgaa atattattta tgatgtgggt aagggaaaca
     3241 ggcgtaatac cagcagcact ttgtggtatt atttcagcaa tgaaagttcc tggatacgaa
     3301 gtgatttcat ctgtagtatt tatgactata ctaattacat tagtaataca aggaagtact
     3361 acaaaattag tagctaaaaa acttggatta ttagaagaag aagtgataaa tataagtgaa
     3421 aaagtatcaa ctttttaaag ttttgcttta aaatagtacc tgttaatggc tattttaata
     3481 ttgtctaatg atgattattg aaatagtcat ttttttatgt ataagtaatt tacagaattt
     3541 acatattaga catatttatt atcaaaattt gttgaagcta tgatataatt agttgtattt
     3601 aaaataagaa tagcaaataa gggaggaaat ttatgtttac ggttatggat attgtacagc
     3661 cagatacagt agaagaagcg tactcaattt taaataaaag aaaaactaac caagtaattg
     3721 gtggaagtgc ttttttaaga atggggaaaa aaagaatagg aacaggaata gaattatcta
     3781 aattaaattt agattatata aaagagtatg aagattacgt tgagattggt tctatgacta
     3841 cttttagaac attagaaaca agttccataa taaaaaataa ttttggaaga ataatagaag
     3901 attcagttaa aaatataata ggagttcagt ttagaaatgt agtaacagtt ggtgcaacag
     3961 tattttctaa atatggtttt tctgacttga tagtagcatt actttcatta gatacagaag
     4021 tagaattata taatattggg agaattagtc ttgaagagtt tctaaataga gattatgaga
     4081 aagatttact tattaagata tacataaaga agacaaataa gaatgcttct tataaatcac
     4141 ttagaaatgc aaagagtgat tatccaattc taaatgtatc tgtatcaaaa catatggaac
     4201 aatttaagtt atgtgtagga gcaagaccgc agaaagctac gattgcaaaa caagctagtg
     4261 aatttctatc taacaatgaa atcaatgaaa ttaatataga taaagcagta gaaatagcat
     4321 cagaagaact aacttttggt tctaacatga gagcatctag ggagtataga aaagctatga
     4381 gtaaagtact tttaaaaaga gctataatgg aggttattta atgttagtaa agattaatat
     4441 aaatgggaag aaaaaaagtg ttgatataga accagaagaa tatctggttg atactttaag
     4501 aaaagttggt aatttaagtg tgaaaagagg ttgtgacaca ggctgttgtg gtttatgtac
     4561 agttttaatt gacaagaaac ctacattatc ctgtgcaaca ctgacattga gagctttaga
     4621 taaagaaata actacaattg aaggtttaga aaatgaagtt aaagaattta gtgaagtttt
     4681 ggtaaaagaa ggagctgagc aatgtggttt ctgttctcct ggctttatac ttactgtact
     4741 tgcaatgaag gatgagcttg aaaatcctac agatgatgaa ataaagcatt atcttacagg
     4801 aaatctatgt agatgtacag ggtatatggg acagttaaga gctatcaaaa cttatctgga
     4861 ggtaaaatag aacatgaata tagttggaaa aggaatcaag aaaatagatg gaatgagtat
     4921 cacaacagga aagcctgtat atacagatga tttatcagca aaagatgctt tggtggtaaa
     4981 gatacttaga agtcctcacg cttatgcaaa aataaaagat atagatacat caaaggcaga
     5041 aatggttgat ggtgttgaat gtgttttaac atataaagat gtaccaaaat ctcgatttac
     5101 acttgctggt caaacatatc cagagccatc tccatatgat agattaattc ttgaagatgt
     5161 tgtaagatat gtaggtgacg aagtagctat agtggcagct atagatgaaa aaactgcaat
     5221 taaagcaatg aatcttatca aagtaaagta tgaagtactt acacctgttt tggattttga
     5281 agaggcaata ggaaataaaa ctatggtaca tgatgaagat agacattgta actttgatat
     5341 aggtatgcaa agagaaaaaa atatagtatc ccatcatgat tatacaaaag gtgatgtaga
     5401 aaaagtatta agtaattgtg atgtagtgat tgaagaaact tattatactc aagctcaagc
     5461 acatgcaatg atggagacgt atagggcata caattattta gaccatatgg gaagattggt
     5521 tgtagtaagt tcaactcaaa taccatttca tgtaaaaaga catttatctc gtgcactaga
     5581 aataccagct agcaaaatta gggttataaa acctagaatt ggtggcggat ttggtggtaa
     5641 acaaactgca tgtgttgaga ttttttctgc aattgttact ttaaaaacag ggaaaccagc
     5701 taaaataatt tatgatagaa aagaaacttt taattgttca acaagtagac atgcaatgag
     5761 attaaaagtt agactaggtg ctacaaatga tggcataata aaggcaatag atataaaagc
     5821 actttctgat acaggagcat atggagagca tgcttctaca actattggtt tggttggaga
     5881 aaaaacttta ccaatgtata ataaagttga agcaacaaga tttattgcag atgtggtata
     5941 tactaataag atgccagcag gagcacttag agggtatgga gcatcacaag gatgttttgc
     6001 tgttgaatca actataaata tgcttgctaa taaattaaaa atggacccaa cagatttaag
     6061 gttaaaaaat gtggtaacag aaggtgaaac tacatttgca tatggtaaaa ctttaaatag
     6121 tgtcgattta ataaaatgta taaataaagg caaagaactt attggatgga atgaaaaata
     6181 tccttgtaaa catcttgata atggaaaaat tagaagtgtg ggtatggcaa ttactatgca
     6241 aggttctggt atacaaggtc ttgataagtc ttcagctgaa ataaaattga atgactgtgg
     6301 agattatact cttatgatag gttctactga tatgggtaca ggaagtgata cgattttagc
     6361 tcaaatggct gctgaggttc ttgatacaag cattgaaaat ataacagtta tatcagctga
     6421 tactgactta gttccatatg acccaggttc atatgcttca agtactactt atgtaacagg
     6481 tatggcagta gttaaggcag ctcaagactt aagagaaaaa ataatttctg ctggagcaac
     6541 taaactaggt gttgagaagg atgaagtaaa atttgatggt ataaaattaa ctagtaaaaa
     6601 aggtagcact ttattattcg atatagcagt tgattctaca attggtccag atactaatca
     6661 attaataggt cttgcttctc atggtagccc agtatctcct cctcctttta tagcaggttt
     6721 tgcagaaact gaaattgaca cagaaactgg aaaagttgat ttagtaaatt atgtagctgt
     6781 agtagattgt ggaacggtta taaataaaaa tctagctaag atacaagttg aaggtggaat
     6841 tgttcaaggg attggaatgg cattatttga agaagttaga tacacagaaa aaggaagaat
     6901 ggacacaaat acatttatgc aatacaagat tccagctaga tgtgatattg gaaatgttaa
     6961 agtagatttt gttgaaactt atgaaccaac tggaccattt ggtgctaaat ctgttggaga
     7021 agttgttata aatacacctt taccagcaat acaagaagct gtgtttaatg gaattggtgt
     7081 aagaataaat acactcccta ttacacctga aaaagttttt atggaaatga ataaataatt
     7141 atttatgaaa atttagacta gttttacatg ttaaacaacc agttatgtca tacctgttga
     7201 aagatattta ataagtagtt attataatat tatgaatttt acttataaaa tacaaaatta
     7261 aataagggga tgatgttttg gctggtaatc taaataatat gagagcagta aataatttta
     7321 gaggagataa gaacatttta gaatgtttag tcagctttga gggtcgttca ataagtcaga
     7381 gaaaagtaag ggtatttttt aaagaaaaac aaaatcaaat agaaattgat tttgcagaag
     7441 aggaaatttc taaattggtt gaaaatgttg ttttaaatac atcatatcaa gaaatgttat
     7501 atgatgaaat agagaaacaa ctggaaattg attgtatagg tacttggatg atattatcta
     7561 aattaaaaga tggtagtaga gttcactgat tttaaaataa attattagag cctaatttta
     7621 aggctctttt ttgctgtttt taattaacaa tagaaaactt atctttagtt tgtatataat
     7681 tttaatatca tatattctat atatataaaa ttgaatttgt atgtattata ttgtataatg
     7741 taaaatgaat tggaaaaata gttcgataaa ataatttgtt tttataaaat tactgtttaa
     7801 gtttatagat tttgtataaa ataaagttat gttattaatt tttttagaaa taaaactttt
     7861 actaggagac agatatgaga aaaaatagta ttaatatagc actaactgca gcaattacag
     7921 caatctatgc agttttaaca ttatcattgg gatttataag ttatggacca atacaattta
     7981 gggtagcaga gattatgatg cttttggcat ttttagataa aggatatata gtaggtctta
     8041 cattaggttg ttttttagca aatgtaatag gaccatatgg tgtacctgat ataatttttg
     8101 gaacattagc cacatttata agtgcaagta tgatttatat tactagaaag ttaggtaaac
     8161 agaataaaag tactttagtt atagcttctt tatggccaac tgttataaat tcgattgtgg
     8221 ttggtctaat gttaaatgta ttctttgggc ttccattaat tctatctatg atacaagtag
     8281 gttttggaga atttgtagta gtgacaattg taggagtacc atttttctgc tttttaatga
     8341 aaaaatataa aaatgtcatt aatattaaat tttaaatagt gtatagtaat ttaattaatt
     8401 gagagtatta ttagtgaaaa gaggtgttta tttgtcgaag gtaaaaagat tgactgatgt
     8461 ttggatatat attaatgata agcaaaagtt tacaataaaa gagttgtcag aggaatttaa
     8521 tctttcagct aaaacaatac aacgatattt aaaagaatta aataaaatgg gacttccaat
     8581 tcaagcagaa caaggtagaa atggaggtta tagggtgcta aataatagct atatacctcc
     8641 tgttatattt acagaaaaag aagttatgat tatactattt gcacttaagt cacttcagat
     8701 ttataattat aagttaatgg aaatagaaat taattctata atgagaaaag taagttatga
     8761 acgtaaaagc agtataaaag taggtataga aaatattaaa agatacattg gctttgtagc
     8821 taatgatact aatgatggag attttaagag tagtaatgta actgagtttt ttagagcttc
     8881 ttcagaatct ctaattttaa atattaagta taagtgtggt aatcagattt tggaaaaaaa
     8941 cgtatgccct ataggtatat atttaaataa gggagcatgg ttttcaccag catatgattg
     9001 taaaagtgat aaaataatat tagttcatat agataatata attgatataa aaagaacagg
     9061 agaaagtaaa aaaatacata taaacttgga agaatggtta catgaagtat ataacaattt
     9121 atatggaaat agttcaacta ctaaaaaatt tggtgaaatt atttatctaa atgtattatt
     9181 aactaaagaa ggtgtttcta aaataaagga cagttcttgg aatttagata tggagctaaa
     9241 tgaagatggt agtggaataa ttagtacatt cataaaggtt gaagatatag attgttatgc
     9301 ttcgatttta ttttttattg gaaataatgc taaggttata gagccaaaat ttttgaataa
     9361 gctactttat gataaggcca atgagttaag atatttttat gaagaaaata tggtataata
     9421 tttagaaatg ttgaaattaa ataattatta aggagatata cgttataatg gaaaatttta
     9481 ataagaatgc taaaataatt ggtattggag ctgaaggtat taatataata aatgaagtag
     9541 aagaaaaaat aaaagcaaat atggatatag aaaaaataaa cataaatcaa gagattgaaa
     9601 aagaatatgt tagaagtctt ttagatggtg tagatatatt atttttgata tattcatctg
     9661 aagataaaca tattagagat attataaaag ctgtttcata tatgtcaaac gaaagaagag
     9721 ttctatctat aggaatggat tgttcagaga aagaaaataa agaagattta gagcttggga
     9781 gagagtttaa aatcaataat gatagtatat ttaaatttgt tgatttaatg aatatcatgg
     9841 tagagtctat ttctgattct tgcatgataa atatagatat tactgattta aaagaagcta
     9901 ttgtaggaga taaaggaatt aagtattctt ttgaagagtt tgaagataca aagtcatata
     9961 gcgagatagc tgacatttta tttgacagga tggaatatat tggtgaggaa tttataagta
    10021 agaaaggaat tgtatttgtt gaaggaagtc cagaattttc tataatggaa ttgaatgatt
    10081 taataagtaa tattcagagc aaggtagaag aaagctatga agtaatattt tctttatata
    10141 taaaggaaaa tttaaatgga aatattagag taggcttatt gtataattag tatattttag
    10201 atattaagga gagtgtatat gtctgaaaat ataagaggta cagagtattg gttaatggaa
    10261 gaattttttt atcaggaaac agacacacca cagattttta gagaagaaag cataattgca
    10321 cttggatttg acataaaaat aaatttaaaa aaagtattca gtatggggaa aaaatcagaa
    10381 aagtatatta atgagaattg taatgataaa gattttataa aaaagtttat gtcgattaaa
    10441 aaaggagatt attttttata taaagcatat caaaatatag aagaaaaagt taaatgtaat
    10501 gtgtctattg gcatagttga agaagatttt gaaaatggat atgaattaag tcatatttta
    10561 gggcatacac taccagtaaa atggatgcat aattttgata cagtttcaaa ttgtaaagta
    10621 tatacaagtg aattttataa attaaataat aatgatatta gctcatattt agaaattatt
    10681 aagtcacaag ataagaaatt attgagaaaa agaatagaag aaagtgaaaa taataaatgg
    10741 tatttaaaaa actattatta taaaaatgta gataagtgtg tagatgatga agaattattt
    10801 attcagccca ttaatctaga acaattagaa agcctaaaaa atataaagac agatgattat
    10861 attttattgt ataatagcga gaaagtaatt tgtgaaaatg accatacaat gaagagtcta
    10921 tttggcgtat gtcaagttat ggaagggttc gataaagaga aagtaagtgc tttggaaggt
    10981 ggatattttt ttcctgttag atggatagag tatgaaaagg agaatataga cggaaatgca
    11041 tgggttatat ttgaaaataa tagtatagtt gaaaagtatg taaaaagatt tactaataaa
    11101 atgccattaa atactatact ttatggacca ccaggaactg gtaaaacata caatacaaaa
    11161 cagatggttt acaatctagt aagtgaaacc agtctaagaa acaaatacta tacaggttac
    11221 ttagattata aaaacaatgt agaattttgt acatttcatc aatcatatgg atatgaggaa
    11281 tttatagagg gtcttaagtc tgatggtgaa ggcaatttta agcaagaaga tgggatatta
    11341 aaggatatat ctatagaagc atgttataat gcattgaaat ttgaaaaaaa gatgagcttt
    11401 gagttggaaa aagatagctt gactttagaa actataaaag acaggaaaaa gaaattagta
    11461 ttagaaaata tagaatatag tgagagtttt aattttgaag aatcagaaaa ctatgtttta
    11521 ataatagatg aaattaatag agggaatgta tctaaaatat ttggtgagct aataacatta
    11581 ttggaagatg ataaaagact tactaaatca aatcaaacta ttgtcaaact accatattca
    11641 aaggaaaaat tttctctacc tccaaatttg tatatagttg gaactatgaa cacatcagat
    11701 aaatcaatag cacttttaga tatagcttta agaagaaggt ttaattttga agaaattatg
    11761 ccagattatg atttattgtc tattgtagat ggtatagata ttagaaaaat gctatataca
    11821 atcaataaaa ggatagagtt tttatatgat agagatcatg ttattggaca agcttatcta
    11881 cttgctgtag aaaatattaa tgatatagta gtagtattta gaagtaaaat aataccactt
    11941 cttcaagagt atttttatta tgattcagaa aaagtaggtt tgattttagg aggaattgga
    12001 agaaatgaaa aagataaata cattgtttat aaagaaaaac ttatagcttc tgagttattt
    12061 aaaaataata atgcctcaat aatggagagt aaagttaact attgtataaa acaaaacata
    12121 tctagtgagg agctaaaaaa tatatatgag taaaaatata tatgttaagg aaacctatga
    12181 atggataagg gtaggtaatg gtgaaaatga gcttacagaa attgaatatg aaaaattgct
    12241 taaatatcta gagaacaata atgatgtatt aaaaagtaat ataatagata ttaaatacaa
    12301 aaaacttaga tttataaact atgtaggcat catatgtttt gaaaatgtaa tacttgaaat
    12361 acttcctaaa ttgtcattaa gtgataatct tgtaaaagat agagagatac tattacagat
    12421 gctttctata tgtaataaaa ttccaattac aatgaatgaa aaaataagat tgagtttgaa
    12481 aaattataat ctcttaaatt tttttgttat gtatttcatt gagagtatgc aaacacagat
    12541 gaaaaaaggt atttattttg aatatataaa taaaatagag aacttaaatg ttatgagggg
    12601 taaaatatta ttaagtacat atgcaaaaga aaaaggcatt tctccaatga aaataagatg
    12661 tgaatatgat gagtatagtg aaaataattt cttgaatcaa gttcttaaaa aagcatgtat
    12721 atctatttta tgtagaataa atgacaattc aattcaaggc aagattaaaa aaattttaag
    12781 ctattttcaa aatgtagatt taatttatat agatagaaaa aaactattgg attataaatt
    12841 ttataaaaac aatgatagat ttaaagattg ttatttacta gctagactta tacttttaaa
    12901 tttgtctatg gataatagtc aaaataatca agaggcattt tctatattat ttgaaataaa
    12961 tactttgtat gaagaatata taggaatttt aatcaaaagt atatgggaca attcatttag
    13021 agaaacatat atacaagata agagtaaatt tcttttgaaa aatgaacaaa caggtaagaa
    13081 aaactttaat ttaagaccgg atatagtttt atatgactta aaaaatgaat atgaaattat
    13141 aattgacact aaatggaaag ctattgaagt agattcaaat gttttttata ggtcaagtga
    13201 tatataccag atgtatgcat atataacagc atatgaaaat gcaaaaagat gtatattatt
    13261 atatccttgt attcaaaaag ataagaatta tagttcctgg aaattatcag aatcatttaa
    13321 gggtaagttt atagaagcaa aaactgtgag gttagatgat ataaaaaaca caaaaaatga
    13381 tttaaaaaag ataattttta attataaatt ttaaaaataa gaattttaaa atttataaaa
    13441 gtaattttat ataggtataa aaattacgag tagtataaaa aatttaataa gaacttaaat
    13501 taaaaatttt aaaaattatt tccatataaa atatggcatt gtaattgctt atttaataga
    13561 gcatttttgt aaaatgaaga aagtatatct atcaaattaa aactaagtag atatactttt
    13621 tattaagttt tgttttaaaa taatattatt aaattataac taagcttttc tgttatgata
    13681 taattaaata gataatgtga atgattatta tatagaatac ttatttggag ttgatatttt
    13741 atggacaaac acagtgattc agtaatgtat ggtggaatgg aagtatataa tatttgggga
    13801 acaacaacag tagactccat aattggagag tctgatgtaa tgcgtgctct taagaataga
    13861 atttgtaaaa ttggaaatag tgattctact gtagctataa ctggagaaag tggcactgga
    13921 aaagaattaa tagcaagagc cattcatctc gcaggaaaca gagggaataa aacattcgtt
    13981 gctataaact gtgctgctat accagaacct ttactagaaa gtgaactttt tggatataca
    14041 aaaggagctt ttagtggagc agattcaaaa ggtaaaattg gtaagtttga attggccaat
    14101 ggaggggttg tatttttaga tgagatagga gatatgccaa ttcaactaca atcaaagtta
    14161 ttgagggtat tacaggaaaa gaagtttacg agaataggtt caaatgaact aattgatata
    14221 gatgttagaa tcatatcagc tactaataga gatttatttg agttggttaa ggaaaataaa
    14281 tttagagaag acttatacta tagattgaat gtaatacctt tagaagtgcc tccacttaga
    14341 gaaagaggag acgatataca aatattaata aacaatttta tagacaaata ttcgagaaag
    14401 atgaagaaaa acgtgtacca tatagagcca gatgtggaac aaatgttgct taagtatcct
    14461 tggccaggaa atattagaga gttggaaaat actatagaac tggcattaaa ccttcttgag
    14521 gaagatggaa taatacataa aggaataata aatagaaaga tacttgaata ttttaagtta
    14581 aataatataa atataaagtt acttgaggaa agtgactatg agataagtat ggaacaagac
    14641 atacttacac ttgaagagtt tgaaagagcc tatataaaga aagtgttaaa gttttacgga
    14701 aatgatacta agtctaaaaa actggctgcc aaaaaacttg gaatatcact agctacattg
    14761 tacagaaaaa tagatgtata ataattaggc tttttattct caattctaaa atttgaaatt
    14821 ataaaattga taaaaaacac ttggaaaact attttctaag tgtttttttg tgtaatagca
    14881 ttttattatc caaaaataaa aaaaatttaa aagaatttaa aaaaataaat gctttaataa
    14941 attatcaaat actaacaaat ataataaaaa ttatatatgt aaaacaatta tgttaaaaaa
    15001 ttggcattat aattgcttca tattaagttg agatgacaaa ataaaaaaag aaaggatgtt
    15061 gtgtgagata ataataactg tcattaaaaa atagttggga gtgataacct tgagtaaata
    15121 tcaaaagaat gtttctatgt ttgatattga tggaaggcca ccaattttaa agtgtttgcc
    15181 actatcaatg caacatatac tagcaatgat agttggaact gttacagtac ctatagtcgt
    15241 aggaggagct gtgggtgtta gccctacaca aataacactt ttagtgcaat atgcattaat
    15301 aatagctggt atatcaacac ttatacaact atatccaata ggaaatattg gttcaagatt
    15361 gcctataatt tttggagttg gttttactta tgtaccaaca cttgtagcag tcggaggaaa
    15421 ttatggatta gcaagcattt tgggtgcaca attaataggg ggagtggcta cagtattaat
    15481 agggatattc ataaaaaaga taagaaaatt ttttccgaat atagttgcag gaacagtggt
    15541 ttttacaatt ggattatctt tgtatcctat agcaataaat tatatggcag gtggtgtaaa
    15601 tagtcctact tatgcctcta tgcaaaactg ggcagtagcg gctataacat tagtggtagt
    15661 tataggtctt agtcaatttg caaaaggata tgcaaaattg gcagcaatat ttttgggaat
    15721 tatagttgga tattgtgtat ctttagttct gggtataata aattttgacc ctattagaga
    15781 ggcaacttgg tttgcgatac ctaaaccgct tgaatttggg atggaatttg atatgcctgt
    15841 aataatctca gtagtaattg taagtataat caatgctgtt caagcaattg gagacttatc
    15901 agctactaca atgggaggca tggataggaa tatcacagat aaggaattat caagtggagt
    15961 aataggaagt ggaatttgta ctatgatagg agctttgttt ggaggtttac caccatcatc
    16021 atatagccaa aacgtgggga tggtagctat gaacaaagta ataagtagat ttgtgcttgg
    16081 aatagctggt atatttatgt tattgtcggg gtttgtgcct aaatttggtg cattaatgac
    16141 tactatacca tattctgttt taggaggagc tacaatatct atatttagta taataacaat
    16201 gacaggtata aagttaatta ttacagaaga gttgtcatca agaaatatta ccattgttgg
    16261 tttggcaatt gccttaggca tgggaataac atcagtccca gcagcccaag aggcatttcc
    16321 ttcatttgta aagttagtat ttggagaatc tccaatagta attgcaacat tggttgcatt
    16381 cgttttaaat ctaataatac caaataaaag tctagaggat gaggctaaag aaagagctgt
    16441 tatggaagag actaattaag atataataat ttaaaagaat tgtttaaatt atttagtatg
    16501 agattgttag attatttttg atagctattc attttaataa aaaatttaac aaataaatat
    16561 ataccaggca attaatgttc atttaagttg aaaatcgggg aggcaatatt tagaaatttg
    16621 ttaatttttt ataaaaatag ctcagtttag ctgtgtttat cggttgagca ataaattcat
    16681 ggtcataaaa atatttatag aaaataatta taaaaatatt tagtcaagat atttatgtat
    16741 gggaggattt attttatgaa aacacgtaat acttcaaaat atgatgtcga tgggatacca
    16801 ccactaaagg aatcaatacc tttggcctta caacatctgt tagcaatgat agtaggaaat
    16861 atggtacctg cgatattaat agcaaacgtg gtaggactta accaggggca agcaacaatg
    16921 ttgattcagg gttctatgtt agcagcaggt ttagcaacgt ttttacagtt atatccaata
    16981 cctttattta aaggatttaa gttaggttca agattacctg taatgatggg aatgagttat
    17041 gtatttttag gagcttgtct ttcagtagca gctaaagatg gtttagcagc tctatttgga
    17101 gcacagattg ctgctggggt aatcgtattc tttgtaggat ttggagttaa gaaaattaga
    17161 catatattca ctccaatagt ttctggaact ataatagcat gtatgggact tggactattc
    17221 gcaacagcta taaagaattt agctggagga gaaggcacac aaacatttgg aagcccaata
    17281 aacttcacag taggagttat agttgctttt gtaataataa tgataaataa atacggtaaa
    17341 ggtttagtaa aaaattcttc aatattaata ggaatattag taggttatgc tatatcttta
    17401 gttttaggat tggttgattt ctcagccgtt caaggagcag ctatagtatc tttaccaaca
    17461 ccagcagctt ttggattaga atttagacca gagttaatag taatgtttac tattatttac
    17521 ataataggta tagctgatat gatgggtgcc tgtacaatag ctacagtagg agcaatggat
    17581 agagaggtaa ctgacgaaga attagcatca gttgtattag gaaattctat aacttctata
    17641 atttcatcac tatttgcagc tcttccaact ggagtattta gccaaaatac agcaattgta
    17701 tctatgaaca aagttacaag tagatttgta atagcactag gggcacttgt attattacta
    17761 gcagggatat ctccagcatt gggtgcaata atgacaacta taccatcttg tgttgttggt
    17821 ggagcaactt tagtagtttt ctcatcaata gcaatgtctg gtttctctat tatgagtatg
    17881 gatggattca ctgaagaaaa caatcttata gcaggtgtat ctatagcaac aagtatgggt
    17941 cttacaactg ctccacaagt tttagaccaa ttcccagaaa caattggaac tgtccttgga
    18001 gggtcaagta tagtttctgg agcaataata gctatattac ttcaaacatt atttaaatta
    18061 aagtcacgta aaagtgctga aaacgttact tcaaatcttg aagaaaatat tggataaatg
    18121 tattagatat aatatgagaa aaccatatgg taaaatgttg taatgaaagt attcaaaggg
    18181 ggatttaaga tgattgatat actaataaaa aatgcaataa ttgttacagt taataaagac
    18241 agagatgtta tatttgatgg agcaatagct attcaaggtg acagaatctt ggacatagga
    18301 aatacagttg atatcgagcc taagtatctt gatgctaaaa aagttataga tgctaatgga
    18361 aaagtaatat tccctggctt tataaatact cataatcacc tgttccaagt gttattaaaa
    18421 ggtttaggtg atgatatggc acttcatgag tggttaaata caatgatgtt tccatcagca
    18481 aaattcttaa cagaacaaga tacttatgat gctgcaatgc ttggatgtat ggaaggttta
    18541 aaaagtggta taactacaat ggttgattat atgcatactc acaatagacc aggacttaca
    18601 gatggaatag taaaggcata taaagattta ggcataagag gggttgtagg tagaggttgt
    18661 atagatttag gtattcacaa agagcttata gaagatgtgg aaacggttga aaaagatttg
    18721 agaagggtat tcgaaaaata tcataattca gaaaatggaa gaataaaaat ctgtgtagct
    18781 ccttcttcaa tgtgggctat atctgaagaa atgggtaaga tgctttggaa tatagttaaa
    18841 gaatatgatt catattttac agttcatata tctgaaacag aatttgcaag aacagcaaca
    18901 aaggatatac atggagaaat agatataaaa ttacttgaaa aatggggtat agtaggtcca
    18961 gaagttgtag cagtacattg tgtatgtata actgatgaag acatggaaat gcttaaaaag
    19021 tatgacataa aagtttctca taatgtagca agtaatatgt atcttgcttc tggtgttgca
    19081 cctgtgccag aaatgttaaa aaaaggtata aatgtgagtt taggtcttga cggtgcagca
    19141 agtaataacg cacaagatat ggtagagctt atgaaactaa cagctttaca acacaaagta
    19201 aataattgtg accctctggc aatttctgca gagaaagttc ttgaaatggc tacaattgag
    19261 ggagcaagaa ctcttagaat ggaagatgaa ataggttctt tggagattgg gaaaaaagct
    19321 gacctagtaa tatttaactc aatgctttct ccaaaatcaa tacctcttca caatcctgta
    19381 tcaactttgg tatactcagc tagtatgcac aatgtagaga gtgttttagt tgatggaaat
    19441 gtaatacttg aaaatggaaa agtaactaca attgaaagtg aagaacaagt gttgcttaat
    19501 gcacaacatg cagcagaaga attatgtaag agagctaatg taactaatag aatggaagga
    19561 cataagtgga atagcttata ctaatattaa aataagattg taataatatt ctattacaac
    19621 attagtttat ctgtaggagg agaaaatgga aaaaataaaa ttaaatatta atgattacat
    19681 gtatgaaata gaagttgaaa agaatgaaac tcttttgcat gtacttcgtg aaaaattaaa
    19741 tctaactgga gcgaaacaag gttgtaatag tggcagttgt ggagcatgta aagttttgat
    19801 agatggagtt gacatgaaat cttgtaaact tcttgcaaaa aactgcgaag gtaaagttat
    19861 atacactata gaaagttttg ctaatggaga aaatcttcat ccaatacaag aagcttttat
    19921 agaagttgga gctgtacaat gtggatattg tactcctggt atgattataa caacacaagc
    19981 tcttttaaat agaaatgcat ctcctaatga agatgaaatt agagaagctt ttaaagaaaa
    20041 tctctgtaga tgcacaggat atgtaaagat tatagaagct gtaaaattat ctgcagctag
    20101 attagggggt agataattat ggaaaaggta ataggaaaat cataccctct aaaagatgca
    20161 gctttaaaag ttactggtca aatgaaatac gtggctgata tgaaaccaca aaatgtactt
    20221 tacgctaaga tgcttttaag ccctgtagca catgcaaaaa taaaaagtat agatacaagt
    20281 gaagctgaga aagtagtagg tgttagagct atagctactt atctcaatac atcacaaaga
    20341 aaatacaatg gttcattaag attttatgag cacaaaatac ctgaaaatga agttatattt
    20401 tcagatacag ttagatttgt tggtgaccgt gttgcagcag tagctgcaga gactccagaa
    20461 atagcagaga aagctgtaaa acttataaaa gttgaatatg aagaattgcc agctgtattt
    20521 actatacaag atgcaataaa agaagatgct atctgcatac atggagattc aaatatagtt
    20581 tctcaaaaca acataaatgg gggagatgta gaaaaaggct tcaaggaatg tgactatata
    20641 tttgaagatg aatactctac tccagcaata catcatagtg caatagagac tcatagtgta
    20701 attgcacact atgattataa tgataaatta actgtacata caccttgcca aaatacattt
    20761 ggatttagaa taatactatc tcaaattttt gggatgtcat taaataaagt aagagttata
    20821 agacctgcta ttggaggctc atttggtgga aaattagaac ttacaattga accagtagca
    20881 gccgcattat caaaaatgac aagaagacca gttaaaatgg ttcttacaag aaaggaatct
    20941 atgatatcaa caagaactcg tcatgggtct tttgtaaaat taaaaactgg tgtaaataaa
    21001 gatggtgaag taatagcaca agacataaaa atatatacaa atacaggagc atatgcatca
    21061 agtgctttaa atgttatagg agcacttagt cataaagtat ttaaagttta taaaatacca
    21121 aatataaagt ttactgggat gcctgtatat acaaatacac caatagcagg agctatgaga
    21181 ggctatgggt cacctcaaat atttatggct caacaagctc aatttgcgaa aatagcaaag
    21241 gaaataggta tggatttagt cgattttcaa aataaaaatg cagtagagcc agatgatgtc
    21301 gatataatct tccacggttc tcttggaaat cctagagtat tggattgtat agagcaaggt
    21361 aagaagatgt ttaagtggga tgaaaagaaa aaacttccaa aagaagaagg aaaatattta
    21421 agaggtatag gtatggcaat aggtgcacat ggtaatggag tttttggtgc acatagagat
    21481 gttgttacat tgactcttaa attaaatgaa gatggtacgt tgacactgct aacaggagct
    21541 catgatatgg gtaatggtgt tgtaactatg caaacaatga tggtagctga agttttagga
    21601 ataacacctg ataaagttga tacatttgaa actgatacgg atgcatgtac attcaacctt
    21661 ggtgactatg caagtagagg ggtatttgta gaaggtggag gagctaaaaa gacagcagag
    21721 aaattgaaaa atcttatatt agaagaagca gaaaaattac ttgaaacatc aaaagaagat
    21781 ttatatctag acaatggatg tgtaattagt aaacttgatg aaaatgtaaa agcatcactt
    21841 tctgatgtcg cagtatatag tcaaagtaaa tcattaagag agttaactgt tgttgaagat
    21901 tattcttcac cagctggacg tacttcttat ggtgtacatt ttgctgaagt tttagtagat
    21961 aaagaaacta aggatataaa agtagttgat tttgtagctg tacatgatgt tggtagagtt
    22021 ataaatcctc taaatttaga aggacaatta gaaggtggga ttcatatggg tctaggatac
    22081 gcattgagtg aagaattggc atttgatgaa caaggtagac ctaaagctac tgattttaaa
    22141 acatataaat tatttagaac tgtagatatg ccaaaatgtc aagttgcatt tgtagatggt
    22201 tatgaaaaag ctgggccttt tggtggtaag agtattggag aatgtgccgt tgtaccagtt
    22261 gcgccagctg ttgcaaatgc agtatataat gcaactgatg tagagataca ttcattacca
    22321 ataaaattaa aatagtataa attaaagcag aaataacaat ttattgtatt tgtaaataga
    22381 taataaaaat agatttattt ggtgaggaga tattattatg gcaaagatat taggtatttg
    22441 tggaagtcca cgtaaaggag caacagaata tgcagtgtta gaagctttga aagaagcaga
    22501 aactatacct ggtatagaaa ctgagtattg gtcagttaga gggaaaaaaa taagtccttg
    22561 tgtacattgt gatgcatgta taagaaaaga aactatgtgt attataaaag atgatatcca
    22621 agaattagag caaaaaatat tggaggcaga tggaattata gtaggttctc cagtttatga
    22681 tatgaatata actgctcaac ttacagcagt atttaataga cttcgtccaa tgtatttagt
    22741 tcatccagga aaacttcaaa ataaggttgg tgcagctata actactggtg gaactagata
    22801 tggtggccaa gaattgacaa aacttcctat aataaatttc ttcctaatgc atgaaatgtt
    22861 agtgtctgga ggtttaggtg gatgctatat aggtggtaca atatggagta aagatggaaa
    22921 agcaaaaggt gcccaagagg atgagacagg tatggacaca gtaaaaagac ttggaaaagg
    22981 tgcagcagag gcagttatgg tttctaagtt tggtcttgaa aaatggaatg tcgtaaaaga
    23041 agaattagat gttaaaaaag atgaaaaatc acctcttaga gaccactaaa gatttattat
    23101 attattgaat atatacaaat agtgatgtaa tagattattg catcactatt ttatgtttta
    23161 atttagattt tatagatttt atattaaaaa atatagaaac aaagtgtttt gagatttatt
    23221 tttaaatttt aaaaatgaga attaaaaagt gagaagatag aaaaggtttt ttagttatta
    23281 aattctacat acattgtatg aactaaagat agaaaagaaa aaataataaa agcattgcaa
    23341 tttctatact aaagagtcat agaaaaatat ctagtatata tttagtgttg gcatgttaat
    23401 tgcttatata ttaaagtata aaaatttaac aataatttgg aggtatttta gatgttaaaa
    23461 gaaattaaat ggaaagtaaa taatttgcca aagggcgata aggaaaattg tatcaaattt
    23521 ttaaatgaag aagaaataac taaggttaga aattttcaca aaagctttcc tcaatataaa
    23581 gaaactccat tagcaaacct agaaggttta gcaaaaaaat taggtgttgc aggagtatat
    23641 gtaaaagatg aatcttatag atttggatta aatgcattta aagtattagg tggttcttat
    23701 tctatgggta gatacttagc tcaaagatta gatacagata tatctgagtt agggtatgac
    23761 aaattaactt caaaagaaat aaaagaaaaa ttaggagaaa taactttctt tacagctaca
    23821 gatggaaatc acggtagagg agttgcttgg acagctaata aattaggtca aaaatctgtt
    23881 gtattaatgc caaaaggttc ttctgaattt agattaaata aaattaaagg agaaggtgca
    23941 gatgctagta taacagactt aaactatgat gatgcagtaa gattagctaa tgattatgca
    24001 gaagctgatg accatggagt aatggttcaa gatacagcat gggacggata tgaagaaata
    24061 ccagcgtgga taatgcaagg atatggaact atggctcaag aagctataga gcaattaaaa
    24121 gaatatggag tagatagacc aacacacgta tttgttcaag caggagttgg ttcacttgct
    24181 ggtgcagttc aagggtatgt tgcttcaata tatgatgaat gcccaataac agtagtagta
    24241 gaggctgatg aagctgattg ttactataaa tcagcagaag ctggagatgg aaaaccaaga
    24301 tttgttggag gagatatgcc aactataatg gcagggcttg cttgtggaga gccaaatact
    24361 ataggatttg aagtattaaa aaatcatgca gcagcatttg tttcagcacc agactgggtt
    24421 tctgctaagg gtatgagaac attaggtaat cctttaaatg gtgatgaaaa ggtaatttct
    24481 ggagaatctg gagcagttac aactggtctt ttagtagcag ctatggaaag agaagattta
    24541 gcagatttaa gaaaagattt aaaattagat gaaaattcaa gaatactttt aataagcaca
    24601 gaaggagata ctgaccctga caaatataga agtatagttt gggatggaga atatccaagt
    24661 atataaggaa ttactaaaat gcaattatta gatattggtt tacatattta gaagatatat
    24721 aagttctaaa atttagaaaa tatataagta tataaaatac atacattata aaaaatctag
    24781 ggggataatg aaatgttaaa cgaacaaaga aaacaagaag taactgaaat atgccaaaaa
    24841 ttaattcaaa atcctagttc ttctggaaat gaagaaggtg ttgtaaaagc aatagaagag
    24901 tcttttgaaa aattaggttt tgatagttgg tcaagagata gatatggaaa tatagtagga
    24961 tgtataaaag gtaacaagcc aggtaagaaa atattatttg atggacatat agatacagtt
    25021 ccagttccag atgcaagtaa atggagtgtt cctccttttg aaggaaaaat agttgatgga
    25081 aagatatatg gtagaggaac ttctgacatg aaaggtcaat atactgcaat gatgtctgct
    25141 gtagcgtatt ttgctaaaga cactaataga gattttgctg gagaactata tgtagcaggt
    25201 gttgttcatg aagaaatatt tgaaggtgtt tcggctagag agataagtaa ggctgttcaa
    25261 cctgactatg ttgtaatagg tgagtcttca gagttaaact taaagattgg tcagagaggt
    25321 agaggagaaa tagtagtaga aacttttggt aaaccagctc actctgctaa tccagaaaaa
    25381 ggtgtaaatg cagtttataa aatggctaat gtaatccaaa agatacaaca attagtacct
    25441 ccaactcatc cagttttagg tgatggaata ttagttttaa cagatataaa atcttctcca
    25501 tatccaggag catcagtagt gccagattat tgcaaagcta cttttgatag aagattatta
    25561 gttggagaaa caagagaagg cgtattagct ccaatacaag ctttattaga tgaaatgatg
    25621 aaagaagacc cagaattaaa tgcaaaagtt tcttatgcag ttgaaaaagc tgattgctat
    25681 acaggaaata ctatagaaag tgaaagattc ttcccaggtt ggttatatga cgaagaagat
    25741 gaatttgttc aagcagcata taagggatta aaagaagctg gaatagattc agaaataact
    25801 caatactcat tctgtacgaa tggaagtcac tatgcaggtg aagctggaat aaaaactata
    25861 ggatttggtc cttctaagga aaatcttgct cacacaatag atgagtatat agagcaagaa
    25921 cagttattta taggaacaga aggttactat ggaatattaa aatctgtata cggaaaataa
    25981 tatttagttc acaataaatt atttaaatat agtctagagg tgctgaatat agcaccttta
    26041 gaaaatacaa ttttaaataa agttttacaa tacttagaaa atactttaaa gcttaaaagt
    26101 taggaggtat atatgggaac aatactaaga ggtggaacta taattacctc tgataagact
    26161 tatataagtg atttaaggat agaagatgaa gagatagttg aaataggaaa taacttagaa
    26221 ataaatggtg ataaggttat tgatgctaca ggtaaaattg taattcctgg tggaatagac
    26281 acacatactc attttgatat gaatgcaggt tctattacaa ctgcagataa ttttgaaaca
    26341 ggaacaagag cagctatagc tggaggaact actacaatac tagattttgc agaagccaat
    26401 gagggggaaa acctactgca aggtgtagaa gcatatcata aaaaagcaag tggaaattgt
    26461 tattgtgatt atggttttca tatgacaatt acatgtttaa ataaagatac atttaatcat
    26521 atggaaaaac ttatttcgga tgggatagta tcttttaaga tgtatatggc atatgatggc
    26581 atgaaagtag atgatggaac aatatacagg gttttaaaga aagcaaggga tttaggttgt
    26641 atagttggat ttcattgtga aaatggggat ttactagatg tattgataga agaaaatata
    26701 caaaatggta atttggagcc aaaatatcat ccacttacaa gacctaacat agttgagaaa
    26761 gagtctgttt caagacttgc tgatataact aaattatcta attcaaaatc ctatgtagtc
    26821 cacttaagtt gtagggagtc acttgaaact gtaaaaatgg ctagagaaaa aaatatagat
    26881 atgatagtag aaacatgccc acagtatcta ttattagaag acaatttata taataaggat
    26941 aaatttgagg gtgctaagta tgtaatgtct cctcctttaa gaaaaaaaga agacataaat
    27001 tacctttggg aaggattgtc tagtggagat attcaaacag ttggcacaga tcactgttca
    27061 tttaatttta aggggcaaaa agacttggga attgatgatt ttagtaagat accaaatgga
    27121 gcacctggtg ttgaacatag gttagcactt ttatatacat atggagtctt agaaaataga
    27181 ataagtgcaa ataagtttgt ggaagttact tctacgaatg ctgcaaaaat atttggaatg
    27241 tatcctaaaa aaggtgagat agctgtagga agtgatgcag atatagtcat tttaaatatc
    27301 aataaagaag aaacaattag ttataaaact caaaaacaaa atgtagatta tactccatat
    27361 gaaggattta aggttaaatg taaagttgaa gatgtatttt tgagaggaaa tcatgtagta
    27421 caaagttgta atgttaaaga acatccaaca ggtcaatata ttaaaagaaa aattactaaa
    27481 taatgcgggg ggaaataaga atgatggata tacttattaa gaatgccata atagtaactg
    27541 tgaataaaga gagagaagtt atttttgatg gggcattagt agtaaaagat aacaagattg
    27601 ctgatattgg aaattctaaa gagatagaaa gtaaatatac tgatgttaaa aaaattatag
    27661 atgctaaagg taaagtttta ttcccaggtt ttataaatac acataatcat ttattccaaa
    27721 ctttattaaa aggattggga gatgatatgg tacttaaaga ctggttagaa actatgacat
    27781 ttccagcagc taactattta gagccaaaag atacttatga tgctgcaatg cttggatgta
    27841 ttgaaggact tagaagtggt ataacaacaa tggttgacta catgtatcct catagtaagc
    27901 caggtctttg tgatggaata atagatgctt ataaagaatt aggaataaga ggaatacttg
    27961 gaagaggatg tatgaataca ggagctcaat ttggagttca tcctggaata atgcaagatg
    28021 tagaaacggt tgaaaaagat gtaagaagat tgtttgaaaa acaccataat acagaaaatg
    28081 gaagaatcaa aataggagta gctcctgcag caatatggtc aaattctcaa gaaatgcttg
    28141 aaatgctatg gagagtagta aaagaatatg atgatgcttt atttacagta catatatcag
    28201 agactccttt tgatagagaa gcagcaaaag aattgcatgg gcaatatgac atagatgttt
    28261 tagaaaaatt aggaatactt ggaccaaatg tgcttatggt acattgtgtg tatctaactg
    28321 aaaaagatat ggaacttact aaaaaatacg atatgaaagt gtctcataat acagcaagta
    28381 atatgtactt atcttcaggt gttgcaccag tgccagaaat gcttaaaaaa ggaataacag
    28441 ttagtttagg agtagatgga gccgctagta ataactctca agatatgctt gaacttatga
    28501 aattaacagc acttcaacat aaagttaata agtgtgaccc attagcaatg tcagcagaaa
    28561 aagttcttga gttggcaact atagatggag caagagctat tggaatggaa gatgagatag
    28621 gttcattgga gataggtaaa aaagcagact tattaatatt taatccaatg ctttcaccaa
    28681 aagcgatacc tatgcataat ccggtatcta cattagtata ttcttctagt atgaaaaata
    28741 tagagagtgt tatagtagat ggaaatataa taatggaaga ttcaaaaata ttgacagcta
    28801 atgaagagaa agcattaaaa gatgctcaag atacagctga gagactttgt gtaagaggaa
    28861 ctataaaaaa tagaatggaa ggtcataaat ggaatagcct ttattaataa atgtaattta
    28921 ttcataaaaa agtatagtaa aactttagct taaaaatatg agttttgagg tgatttattt
    28981 gattatcaaa tgtaccataa ataataaaga aaaagaatta agtataagac cagatgattt
    29041 tttagcagat acattaagag aaaatggata tgtaagtgtt aaaaaagggt gtgatacagg
    29101 ctcatgtggg ttatgtacag tgatggtaaa tgacaaggcc gtgctttcat gtaattatct
    29161 tactgctaga gtagaaggtc agcatattac aacacttgag ggtgtcttgg atgaagcaaa
    29221 gaagtttgga gattttcttg cagacgaagg ggctgaccag tgtggatttt gtgctcctgg
    29281 atttataatg atggtcttgg caatgaaaag agagcttcaa aatccaacag aagaagaagt
    29341 tatagattat gtaaatggta acctttgtag atgtacagga tataaaggtc aattaagagc
    29401 aatacataaa tatttaaaca cttagacttt taagtgaaaa ttaagttgat atggggagag
    29461 agtatgataa ctataaagga atatgtagtt ccaaaaagtt tagatgaagc ttatgaactg
    29521 ctaatatcaa gaaaaaacaa cataatactt ggaggatgtg gatttttaaa actaggtagt
    29581 aaaaatattg gttcagcaat agatttaaaa gacttagctt tagattatat aaatgaaact
    29641 gatgatagca tattaattgg agcagataca agtttaagaa ctttagaatt aaataaggtt
    29701 attaaaaatt actgtaatgg ggtaatttca aacgctgttt ctaatatagt aggagttcaa
    29761 tttagaagtg gagctagagt aggagctagc gtatttgcta agtatggatt ttcagattta
    29821 ataccttcat tactagtggt agatgcaaag gttaagttat ataaaaaagg ggttatgaac
    29881 ttagctgatt ttttagaaaa tgagcttgaa aaagatatat taatagaagt tatattacct
    29941 aaaaaagatg ctataggtgt atttgattct ataagaaaat gtacaggtga ttttgcagta
    30001 ttaaatggag caatgttaaa agaaggaagt atttataaaa ttgcgatagg cgctagacca
    30061 agaagagcaa aaattgccta taaagcaagt gaaatattaa gtttagaaaa tgatatagaa
    30121 aaagctggtg aagtatcaag tgaagaactt tcatttggaa gtaatataag aggaagtaaa
    30181 gaatacagaa aagatatggc aaaagcctta gtagtgagaa tgtataatag tattggaggt
    30241 gagtgtgatg gtaaataaag aggtaagaaa aatagatagt gaagccattg ttactggaaa
    30301 accaatatat acagaagatt taatttttca taaagatgtt ttaacaatta agcttcttag
    30361 aagtccacat gcttttgcga agataaaaaa catagatata aaaaatgcat taaaggtaaa
    30421 aggtgtagta aacatattca cttacaaaga tgttccaaat tatagatatt caatggttgg
    30481 agagtcatat ccagaagcat cacctcatga ccaattaata cttgaagacg tagttagata
    30541 tgtaggagat gaagttgcta taatagccgc tgaagatgaa agggctgcta ttaaagctat
    30601 gaaacttata aaagttgaat atgaagtaat gactcctata ttggatgcaa gagaatcgga
    30661 aggaaataaa attttaatcc atgaagaaga tgatttgttt tgtccatttg attttggatt
    30721 ggatgctaca aaaaatattg tatcgagaga aaaaatgggt aaaggggatg tagaaaaaga
    30781 gtttaaagaa agtgatgtaa tagtagaaca ttcttatatg actcaatcac aagcccattg
    30841 tatgatggaa actcatagag cttatacgta tatagatacg aatggcagat tagtagtaac
    30901 ttctgcaaac caatcagctt atcatatgag aagacaggtt tctaaagcac tgggaatacc
    30961 tctttcaaaa gtgagagtaa taaaaccaag aataggtgga ggttttggtg gaaaaaacat
    31021 agctgtaaca gagatatatg catcatttgt aacttggatg acaaaaagac cagcaaaact
    31081 aatttatact agagaagaaa cttttgcaat gactaatact agacatcaga tgttttttga
    31141 tataaaaatt gggtcagata aagaaggaaa cataaaagct atagatatga aagcattgaa
    31201 caatacaggc gcttatggcg ataatggacc ttcagtttgc tctgaatcag gtcataatgt
    31261 acttccaaca tataataatg tacctgcaat aaaatttgat gggagaactg tatatactaa
    31321 tttagttcca ggaggagcat taagaggata tggagcaaca caaggtacat ttgcacttga
    31381 ttgtgcaatt gatgaattag cgcataaact taatatggac ccaacagaaa taaagttaaa
    31441 gaatattata aaaaaacaaa ctgaaggcgg aataatgaat tttccaataa gaagttgtgc
    31501 acttgatgaa tgtataatta gaggtaaaaa acttattgga tgggatgaaa agtaccctgt
    31561 tagggatatt ggaaacaata aggtgagggc tgttggaatg tctgtgggaa ctcatggttc
    31621 tggtatagcc aacatagaca tggcaatagt aaatatgagg atggatgaag atggaactta
    31681 taagttgttt tctgggtctt cagacttagg aactggttct gacacaatac ttgcacaaat
    31741 agctgcaaaa gcattgaata catctattga tagaatttcc gtttatacag gagatacaga
    31801 tatgtgtcca tatgatactg gtgcatacgc ttcttgtact acttatgtaa ctggaaatgc
    31861 tacaataaaa tctgctgaaa gtttaaaaca aaagatatta aaagtagcac agaagaaact
    31921 cgatttacca atagatgatt taatactata tgaagacaga gtttgttata gtgaagatgt
    31981 agagaagttt gttttgttaa gtgaattagg aaaagaatct gttggtggtg gaaatcaaga
    32041 agttttatat tcatctgaat cttatggtat acaagagagt gctaaaccat tcttagcagg
    32101 atttgctgaa atagagttag ataaaacaac aggggagttt aaagtaataa attatgcttg
    32161 ttctacagat tgtggtacag ttatgaatcc tgcacttgct agaatacaag ttgaaggtgg
    32221 tgtaactcaa ggtatagggc ttgcaatgta tgaagaccct agacatggtt ctgatggaaa
    32281 gcttcaaact tctaatctat tacaatacaa agttccaaca aaaaaagata taggaaacat
    32341 aattgttgat tttgtagata attatgagcc aacaggtcca tatggagcta aatctttagg
    32401 agagatagtt attcatacac ctgcaccagc aatagcaaat gcaatataca atgccacagg
    32461 agttcgtata agagaacttc ctataacttc tgagaaagtt tatatggcca tgaaaaaatt
    32521 aaatcaggga ggtaaataaa tgattgctat taaaagtaaa tacttaatat cttctgctga
    32581 tgaaatatat acaaattctg ctgttgtagt agaaaatgac attataaaag atatattgcc
    32641 aaatgaagaa gttgaaataa aatataaaaa tattgaagaa ataatagata aatcagatgc
    32701 tataataatg ccaggattcg tcaatggtca tatgcatcaa tatggagttc tttctagggg
    32761 aataccggca aatgtacatt ttaccgactt tgaaggtttc ttaaatgact attggtggcc
    32821 atttatagaa aatagaattg gattgaaaga agtgaaggca acaactaaag catcagcaat
    32881 agaacttata gaatctggtg tggtagcttt ttgtgatacc ctagaagctc caaatacaga
    32941 agaaggaact ttaattgagc aaggaaaaat actagaagaa ataggcatga aagcgatttt
    33001 atccttagaa agttgtgaaa gaataagctt tgaaaatgga cttagatgtt taaatgaaaa
    33061 ttctaattta ataaagtgga gtagagaaaa tagtaaatta ataaatggaa taatgtgtac
    33121 acatacaagc ttcacatgtt ctgatagatt tattaagaaa gctaaagaag atacaaaaaa
    33181 attaaatgca ccaatgcaat ttcatttatg tgagagtata tatgagccaa actatgctga
    33241 aaaacatttt ggcaaaaaag cagttgacta ctataatgat ttagatatat tggatgaaac
    33301 tgtattagca tctcagtgtg taaaagtaaa tgatgaagaa atagatatat taaaagaaaa
    33361 aggtgtaaaa gtggttcata tgcctcttag caactgtgaa gtaggtggag gtttttctcc
    33421 agtaccaaaa atgattaaaa aaggtataaa agtggcactg ggtactgacg gatatataaa
    33481 tgattttttt gaagttatga gaggtgcatt tttaatgcat aaatcagttg aagaagatgc
    33541 atcagtaatg ccagcaaatt tagtatttag aatggcaaca gagcatggtg cttatgtatt
    33601 aggacttcaa aattctggta aaatagcagt tggtaataag gctgatataa tagttatgga
    33661 agatgaattt aaaactcctg tgactcttga taatatattt gaccagatag tagttcaggg
    33721 taaaaaagaa tttatatcaa atgtatacat agatggtaga catattttaa aagaaaaaca
    33781 gttagttgat ttagataaaa aagctattgt taaagaaatg aaagaagttg cttgtgaatt
    33841 ttggaaattt taacgaatgt aaatatatat gaaaagggga agcagataat gtataatttt
    33901 ttaggtaaag aattaaaatc accacttata ataggttcag gaccattaac atatagtgca
    33961 gctggatgca agatattaag tgatgcagga gcaggggcag ttgtgactaa gactataaga
    34021 aaagaaagag ctataaatcc agcaccacat atggttagaa atacagctaa tgctctttta
    34081 aataatgaaa aatggacaga ttttgagcca gagcaatgga tagattttga aataccacaa
    34141 atgaaaagag atgggactgt ctgtatagct tcagtaggtc atacaattga agaaagtagc
    34201 gaattagtag agaaagttgc aaatgcagga gctgacttta ttgaattagt atcttatgac
    34261 tatagagatt tgataccaat gcttaaagat gcaaaggaaa gagtaaatat acctgtaata
    34321 gttaaacttc ctcctatgat agatgagata ggcgattttg ctaaaaaatt agaagaagca
    34381 ggagcagatg caataactgc ttgtgattct gtaggaccag catttagaat agacatagaa
    34441 acagggcaac ctttattagg tggaaatgga ataggatatt taagtggaga aactatcaag
    34501 ccaataactt tacagagaat atatgaaata aaaaaacaag ttaatatacc aataattggc
    34561 ttaggtggat gtgtaagtgg agatgatgcc ttagaaatga ttatggcagg tgctgacttt
    34621 gttggtatat gttcagtagt aattttaaaa ggcgcacaag taatatctaa aatacatgat
    34681 gatttaaaat ctaatcttaa tagattagga tataatacta tagaaaatgc ttgtggtata
    34741 gtacataatc atatgggaga tgttaatgaa agacttagct ttgagtttac ttatgatgaa
    34801 gaaaaatgta ctaaatgtaa gatgtgcgag agagtttgtg catatcaagc gagaaaattg
    34861 aatgataaga tggaattgaa tgaagaagag tgtagatatt gtggactttg tatatcagtt
    34921 tgtaaaccaa aagcacttgg aagaaaaatt tcatgttcag agctgaatgt atagattatt
    34981 ttataaaaaa caaagtttta aataaaaata agaaaggcta tctcaaagag ataagccttt
    35041 tttgttgttg accttatttt tgtttatttg tagttatttt agatattaat tagttttgaa
    35101 gtaataaagt gaatcaattt tgtttaatta aaattttaat aattctgata tatatgttaa
    35161 cattgtatag catttgtgta aaatgttata ataattaata gggatggtga tgcaagtgca
    35221 agagaagatt ttagagttat tatatactat aaatgaagat gtagttagca taaaaaatga
    35281 tatgtcggaa gtaaaacaag aaataaatgt gttaaaagaa gatatgtcgg aagtaaaaca
    35341 agaaatgact gtaatgaaag aagatatgtc ggaagtaaaa caggaaataa atgtattaaa
    35401 aggagatatg tcggaagtaa aacaagaaat gactgtaatg aaagaagata tgtcggaagt
    35461 aaaacaagaa ataactgtaa tgaaagaaga tatgtccgaa gtaaaacagg aaataaatgt
    35521 attaaaagaa gatatgtccg aagtaaaaca ggaaatgact gtaatgaaag aagatatgtc
    35581 cgaggtaaga caagagataa atataatgaa agaggatatg tctgaggtaa gacaagagat
    35641 aaatacaatg aaagaggata tgtcggaagt aagacaagaa atgactgtaa tgaaagaaga
    35701 tatgtccgaa gtaagacaag aaatgactgt aatgaaagaa gatacatcag aggtaaaaca
    35761 agagataaat gtaatgaaaa aagacatgtc agaagtgaga caagaaataa ctgtaatgaa
    35821 agaagatgtt tccgaagtta aatcagaagt aaactttatg caaaataaaa taaataacat
    35881 taatgaagat atgaatggaa ttaaggacga ggtatccata gcaaatgaaa aattatatgg
    35941 aattgaaatt aagattgata gtctagaatg tgaagataaa tcaatgaaag agatacagat
    36001 agaacagaat aatattttag gaagtttatt acataattct gaaataaata aagctactca
    36061 tgataatata gaacataaca tagcatatat aaaaggtgac actaattcta taaaagagga
    36121 tatagctgaa ataagaagag acttaaattt agtagagtta gccactagta aaaattggag
    36181 tgatattgtc aaactaaaat cagtaaagta gtattttaat tcactaattt atcatccaca
    36241 aactaagaat tttatat
//
LOCUS       DAEPID010000039        34601 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.039, whole genome shotgun sequence.
ACCESSION   DAEPID010000039 DAEPID010000000
VERSION     DAEPID010000039.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 34601)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 34601)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..34601
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.039"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            complement(441..2828)
                     /gene="cadA"
                     /locus_tag="KR257_002101"
     CDS             complement(441..2828)
                     /gene="cadA"
                     /locus_tag="KR257_002101"
                     /EC_number="7.2.2.21"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429705.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cadmium-translocating P-type ATPase"
                     /protein_id="HBH0030787.1"
                     /translation="MEANNSIKKEFILGGLNCAHCAEEINNKVSKLQEVKSSNLNFIN
                     KKLTVNIKESFNEDTTIEKIIDIIDSTDPGLDIQISSKENAASKTSIKKELILGGLNC
                     AHCAEEINNKVSKLKEVESSNLNFVNKKLTVNISNNFEEDDVINKIKEIINSTEPGLD
                     IQVGSTDKVKGRTTEKSGAVNDTNKKELIPLIIGALVYIFGIYQTATGYESQFSNIVF
                     IVAYVIVGGDVLLRAIRNISKGRVFDENFLMALATVGALTIGELSEAVGVMLFYKVGE
                     YLQGVAVGKSRKSITSLMQIRPDYANLKVNSEVKVVSPEEVNVGDIIVVKPGEKVPLD
                     GVVVDGVSMLDTSALTGESVLREVEKGDEILSGVINKNALLSIEVTKSFGESTVSKIL
                     DLVENSSIKKSKTENFISKFSRYYTPIVVIAALLIAFVPPLVISGEVFSDWLYRGLIF
                     LVVSCPCALVLSIPLSFFSGIGFASKNGILIKGSNYLEALRSVDTVVFDKTGTLTKGV
                     FNVTKLNPEGISEEELLEYAAIAEVNSNHPIAKSILSYYNKKIDLDTIDSYEEIAAYG
                     IRVKHNGNFILAGNEKLMKKENISYSSAKEVGTVVYIAVDKVYRGYIVISDEVKEDSK
                     NAIRSLKEIGVKEVVMLTGDNEKVAKNIAQELELDTVYSNLLPNEKVDRLEDLYEGRT
                     EKEKIAFVGDGINDAPVLARADVGIAMGGLGSDAAIEAADVVLMTDEPSKISKAIEIA
                     NKTNKIVWQNIIFALGVKIIVMILGAGGVATMWEAIFADVGVALIAVVNAMRAMR"
     gene            complement(2851..3216)
                     /locus_tag="KR257_002102"
     CDS             complement(2851..3216)
                     /locus_tag="KR257_002102"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437587.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="HBH0030788.1"
                     /translation="MREEINDCNCNIVHEEIVTEAKSTMPDEEMLYDLAELFKVFGDT
                     TRVKILYALFANEMCVCDIASLLNMTHSAISHQLRVLKQARLVKFRREGKTVYYSLDD
                     SHISQIFDCGLNHIRETYK"
     gene            3415..4263
                     /locus_tag="KR257_002103"
     CDS             3415..4263
                     /locus_tag="KR257_002103"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421082.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0030789.1"
                     /translation="MSNKKKKDLDTSYMPYLDPANYADYITNEEIPQDELRNDPQISN
                     GYTKIPNNQNINNLYPNNVNHYPKSSNSPNNLPNTNNTSGNMNYNTSATNNMPNNMNN
                     NTGMPNNMSNNMNSNMGMPNNMPNNMNSNMGMPNNMPNNMNSNMGMPNNVPNNMNSNM
                     GMPNNMSNNMNSNMGMPNNMSGNMNNNMYGNTGMPNNMNSNMGYNMNNTMGIPNFSCN
                     QNMPPNVLMMIPGVICHNTMQGMPVVMPSTMPPNIYPTPYGSSNMSVQGIPQATNIEE
                     FDEEEM"
     gene            complement(4700..5788)
                     /locus_tag="KR257_002104"
     CDS             complement(4700..5788)
                     /locus_tag="KR257_002104"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425141.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0030790.1"
                     /translation="MNFNFAKATNSRLMGSLGLIINWIDDENNHFCQYFLLDAEGLGL
                     ADYVSLNNPTQEEAYMEEERLMGGFGSDRVELTKDESLFLVSYFGNKNLYYDKLLPGD
                     KCEYIDIIKNYKTDLTIEKLYNKICKRVDEEVEFINYMTMRFIAWDRESLKYFSGSDE
                     IANMHITNINGTLLKNVVSDKGQGRYISEALYEDNDGYYICKIAFCISKCYETGFRIN
                     SLLVTDKEPMYDFEVFDEISKSEFVSVYSVNSPEEFAGVFYRENPFLLKSNMNEGIFF
                     TRFNFNNDHVKENVYIINNDMKAIYYLMGNKFFIGTYNENDCNYINEISQSNYSDYIK
                     FEEKFFFEQNALYDFAESGSLDFDDFLE"
     gene            5913..6641
                     /locus_tag="KR257_002105"
     CDS             5913..6641
                     /locus_tag="KR257_002105"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421079.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HAD-IB family hydrolase"
                     /protein_id="HBH0030791.1"
                     /translation="MKNIAAFFDIDGTLYRDSLMVEHFKKLIKYDIIDQKNWYKHARD
                     TFMDWDKRQGNYDDYLLEICDLYVDSLKGLDKTCINFTSDQVIKLKADRVYKYTRSRI
                     EWHLNQGHIVIFISGSPGFLVEKMAKKYNVTDFLGSDYVFENNIFTGTVIPMWDSISK
                     NNAINDFVVKYDLDLSNSYAYGDTNGDINMLKRVGNPIAINPTKELLSQISLDEEISK
                     NVEIIVERKDIIYSLSTDVNIVDI"
     gene            complement(6843..7334)
                     /locus_tag="KR257_002106"
     CDS             complement(6843..7334)
                     /locus_tag="KR257_002106"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009904849.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0030792.1"
                     /translation="MSIKVAYGGVLLALNVILLTLTNIIPVNTLFIMGLASLLVSIVI
                     MEWGFKSGIAFYIGSIVLGFIVMASKSQWIVYSLTFGIYGIVKYLIEKDRSIYIEYFM
                     KLVFANIMILILYFLLRTIVYIPINIFIIGSFEIAFIVYDYVYSSFIGYYNNRLRKML
                     FKK"
     gene            complement(7345..7788)
                     /locus_tag="KR257_002107"
     CDS             complement(7345..7788)
                     /locus_tag="KR257_002107"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425143.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0030793.1"
                     /translation="MYSNTYNNENFMRARSFIENSEFKKAYDFLKTLTDKCAEWYYLT
                     GFSAMNIGYYEEGEDFLKRAKFMEPENSEYSDALRSYTQYRNDYSNRADNYNRRRRND
                     LDGCCCCCCDDCCCCLGDDCCENCAKLWCLDSCCECFGGDLITCC"
     gene            complement(7778..8617)
                     /locus_tag="KR257_002108"
     CDS             complement(7778..8617)
                     /locus_tag="KR257_002108"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421074.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0030794.1"
                     /translation="MFGYVKINKMDLTFREYDYYKAYYCGLCKYLKRNHGEISRFSLN
                     YDITFLIVLLTAVYNPESISTEEVCIVNPFKKKKVITNDITEYAASMNILLTYYKLED
                     NLMDDKRIKDKLAYYIYKNKLKLAYEKYPEKAEYIKQQLNELNKLEKDKNINIDEVSS
                     IFGNIMGEVFVYKKDENERNLRMIGFNIGKYIYLLDAYEDLDEDFKKGRYNPFIEYID
                     KNDELKEKVKKIIVTSLGFLARGIDNLNLNKNVGIIENIIYSGVYLRYINILESRGGK
                     NVQ"
     gene            complement(8836..10221)
                     /locus_tag="KR257_002109"
     CDS             complement(8836..10221)
                     /locus_tag="KR257_002109"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860725.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amidohydrolase"
                     /protein_id="HBH0030795.1"
                     /translation="MDNLNKKFLMEYIDEIQGELRDISDKIWKNPELQYKEYYASNLQ
                     KECLKKHGFSIEGLEGMDTAFVASYGEGRPVIAVLGEYDALDGLSQKVSTTKEPIVDG
                     GAGHGCGHNLLGTGSIGAVIAVKELIKLKKLKGTIKYYGCPAEEDLSGKVLMIKKGFF
                     DGIDCAFSWHPFDINTPIRIPTLANYSVKFRYNGISAHAAQAPYNGRSALDAVELMNI
                     GCNYLREHIFDNCRVHYVTTNGGKMPNIVPDFAEVWYYIRGVKMEHVRDVFGRIVDIA
                     KGAALMTGTIMEYDIISGVYDYIPNTILTDILSQNMKLVGVQNYNEDDYYFADKLAET
                     VSIDKRSSVSSVLSGNKDITKMNLHDEVTDDTFTHNNCISLSLDIGDVSYIIPTAQCS
                     CSVWPIGISAHTWQSCASAGSDMGFKAMLLASKSISCSINDVMLDELVINKAKKELKD
                     TVGSFKYIPII"
     gene            complement(10394..11137)
                     /locus_tag="KR257_002110"
     CDS             complement(10394..11137)
                     /locus_tag="KR257_002110"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435911.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cytoplasmic protein"
                     /protein_id="HBH0030796.1"
                     /translation="MKKVLIVGESWVKNITHIKGFDTFVTTHYEEAVKWLKEAIESGG
                     YETVHMPAHVAADSFPYKLEELNEYDCIILSDIGSNTFLLSNSTFIDCNSNPDRLELI
                     KEYVNNGGALIMVGGYMSFTGIDAKARFGETAIKDVLPITMIDKDDRVEKPAGIIPEV
                     IDSEHPVLKGIPTEWPKFLGYNKTVARDNCPVLATIGGDPFVAVGEFGKGKSAIFSSD
                     CAPHWGPKEFTDWKYYNKLWVNMLDWLTC"
     gene            complement(11157..12419)
                     /locus_tag="KR257_002111"
     CDS             complement(11157..12419)
                     /locus_tag="KR257_002111"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729135.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="M20 family metallopeptidase"
                     /protein_id="HBH0030797.1"
                     /translation="MKKILLDTLNSKKQEYIDYLKELVSIKTEDVGHGILGGFEKEGQ
                     EYIEKLANYIGFSVDRQEMSEELIKKAKNIYKEGNLGHNYQDRYNLICKYSDDLPGKT
                     IVFNGHVDTMPPGDISKWKYNPYRATEDNGKLYGLGTADMKSGLIASILAVKLIKDSG
                     LNVPGNVKIMSVVDEEGGGNGTINAVMNGIDGDCCIICEPSEQNLIVAHMGFVFFEVE
                     VKGVSLHCGSKWEGVNAIEKAMLLLQDIKELEHNWLMIYKHPLLPSPTINLGVINGGT
                     AGSTVPDKCVFNLCVHFLPNIMSYEQVVNDVTNVIMTRANGDLWLKDNKPNINIYQSG
                     LGFEMDKDSDFVVNAHKILEETLGKKLEIKGSTAGNDARVMKNLAEIPTLILGPGSIE
                     QCHSIDEYVEIKEYLDSILMYASLILNL"
     gene            complement(12603..13601)
                     /locus_tag="KR257_002112"
     CDS             complement(12603..13601)
                     /locus_tag="KR257_002112"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421067.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribose ABC transporter permease"
                     /protein_id="HBH0030798.1"
                     /translation="MSSITKHKEEKSSPLLTKLTSVFRDQGSAAVGLVIIFIIMSVAS
                     SNFLTLDNLINVGRQISINAILAVGMTFVIITGGIDLSVGAVIALVGTFWATTVVNYN
                     APIWVGMILALAIGTILGVIKGAIISTQKLPPFIVTLAMLTIISGASFVFTGGRPISV
                     NTDAFKMLGRGYIGPIPIPVIIMIIVVIAGHFLLKRTNFGRHVHAVGGNEEAARLCGV
                     KVNKVIVKVYALAGLLTALAGIILSSRLASGSPTVGDGAELDAIAAVVLGGTNMMGGS
                     GSIVGTCIGVGIIGILGNGLNLLSVSSYNQMIIKGLVMLFAIWINNIKLKKSAKSK"
     gene            complement(13585..15096)
                     /locus_tag="KR257_002113"
     CDS             complement(13585..15096)
                     /locus_tag="KR257_002113"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860721.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sugar ABC transporter ATP-binding protein"
                     /protein_id="HBH0030799.1"
                     /translation="MSNIILKLSNIAKEFPGVRALDNVNFELFHGEVHALLGENGAGK
                     STMIKILTGAHSKTSGKFIFEGKEIENISPDISKKIGINAIYQELTVFDELTVAQNIF
                     MGKEINGKVLTNDKKMNEEAKKIFDNMGIDINPNSLVKELSIAQKQMVEIARVLSSET
                     KVLIMDEPTSSISKKETEILFRLINDLKESGVSIIYISHRMEELFEICDRITIMRDGK
                     TISTLNTKDVSSEEELVNLMIDRKLDQFFPKRKVEIKEEIMRVENLTKNNVFNDISFN
                     IRKGEILGIGGLVGSKRSEIVEAIFGLRTYDSGKIYLNNEEVKFKTPSDAIENGLGLI
                     TEDRKGTGLFLQMSVKENTTMAGLKKISKFKSIIDRKKEKEILEKYIEALKIKTPHMN
                     QVIQSLSGGNQQKAIIARWLLLQPDILIMDEPTRGIDVNAKAEIYNLMGDLVESGVSI
                     IMISSEIPELISMSDRIMVMREGHISGFLEGEEMVENNVLKLAFGGKINEFNN"
     gene            complement(15150..16112)
                     /locus_tag="KR257_002114"
     CDS             complement(15150..16112)
                     /locus_tag="KR257_002114"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435917.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="substrate-binding domain-containing protein"
                     /protein_id="HBH0030800.1"
                     /translation="MRVRKILSLGIAGILAIGMLTGCSMEGPSKSDNKGGSDKKDLTI
                     GVSTITLQHQFFIDIDEGIKEKAKELGVKVIVNDPDQDVAKQTSAIEDFIQQNVDGMI
                     VLGTDNSAIVPAVEGAFEKMPVVTVDAVLNTENITSYVGTVSYDAGKKLGEYTKKYID
                     EKLGGKSEIAIVTDLKSQIQMQRIDGFKDALKGSANVKILNSQPGYDREESLNTVENL
                     IQSNPDVDIIYATAENSVLGAKAALESAKNKDVKIVGFDLTEEASSGITDGTILAMIQ
                     QQPKEMGRLAVEAVVKAIKGEKVEKNIPVPALLYDKENIKDFKN"
     gene            complement(16160..17050)
                     /gene="rbsK"
                     /locus_tag="KR257_002115"
     CDS             complement(16160..17050)
                     /gene="rbsK"
                     /locus_tag="KR257_002115"
                     /EC_number="2.7.1.15"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895372.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribokinase"
                     /protein_id="HBH0030801.1"
                     /translation="MGNIVVIGSVNMDMVCSVDKRPEKGETVLGNSFFTSPGGKGANQ
                     AISASKLGANVKMISCIGEDGLGEELIRNFRTNKVDYSLVSRNNHKSSGVAVITLCEN
                     DNSIVVVPGTNELVDIELIKKNEEEIKNADIVLLQLEIPLKTINYVVNFCFENRIRVL
                     LNPAPAVKLNEDIIEKVTYLTPNEHEYKIVFDTNEGIEEVLKKYPNKLVITEGKNGAR
                     FYDGEEIKHVSCISVDVQDTTGAGDTFNGALAVAITEGKNLYTAVEYAVVVSGLSVTK
                     LGAQSGMPYKEDVEKYLNNK"
     gene            complement(17092..18105)
                     /locus_tag="KR257_002116"
     CDS             complement(17092..18105)
                     /locus_tag="KR257_002116"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009904841.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LacI family DNA-binding transcriptional
                     regulator"
                     /protein_id="HBH0030802.1"
                     /translation="MSITIKEIGELAGVSKTTVSKVINNKDENISQATREKILKIMKE
                     KNYVPNKLAQSLVTKKTNTIGLLIPDIRNPFFTDVSRGVEDKANEEGYNIILCNTDED
                     AKKEYEGIRTLSERMIDGIIFAASSNTNWKEANYKDIKIPTVLIDKKISMNKETLKGI
                     VKINNFEGAYIATKHLLDIGNKKIIYLSGPLQNEIAVDRLEGYKKALIECNLSYNPAY
                     VFEGKYKIEWGQEFIKNLEKIDFDAIFCANDLIAIGVIRGLKERGLSIPNDISVVGFD
                     DIQTSSLISPSLTTVKQPSYDIGYKASEILINCLRGDKKESFDELIFKPELVIRDSTK
                     ESE"
     gene            complement(18333..19310)
                     /gene="bioB"
                     /locus_tag="KR257_002117"
     CDS             complement(18333..19310)
                     /gene="bioB"
                     /locus_tag="KR257_002117"
                     /EC_number="2.8.1.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895370.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="biotin synthase BioB"
                     /protein_id="HBH0030803.1"
                     /translation="MEKYIIKLKNKVLREKEISYEEALNLISLDTNNKNDFDILLKSA
                     NEIREYFMGRKADLCTIMNAKSGKCSEDCKFCAQSSYYKTGVEEYSLLDYNEILNRAK
                     EMESKGVHRFSLVTSGKGMSGKEFNNILNIYEGLRENTNLKLCASLGIIDYEQAKMLK
                     SAGVTTYHHNVETCRDNFHNICTTHTYKDRIKTIKDAKKAGLDVCVGGIIGMNESEEQ
                     RLKMAFEIRELNVKSFPINILNPIKNTPMENYDVLEPMEILKTTAVFRFIIPNVYIRY
                     AGGRLSLKGYDKVGFNGGVNSAIVGDYLTTVGSGIENDKKMIIEQGFEL"
     gene            complement(19516..19779)
                     /locus_tag="KR257_002118"
     CDS             complement(19516..19779)
                     /locus_tag="KR257_002118"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729134.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0030804.1"
                     /translation="MKIYYEKENSKKANVNNIPSVFAFNFLRNFLTSKEYEETRKEYF
                     INNLTKSQVNQAMKDLKWLFREYEGLEVITMESLDGVKTRIVL"
     gene            complement(19849..20922)
                     /locus_tag="KR257_002119"
     CDS             complement(19849..20922)
                     /locus_tag="KR257_002119"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421053.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF362 domain-containing protein"
                     /protein_id="HBH0030805.1"
                     /translation="MEKSKVYFCDLYSNSQNKNVPNNVRRLFDEAGFKDLIEKNDQVA
                     IKLHFGEKGNTTYMSPVAVRQVVDKVKDCEGKPFLTDTNTLYTGSRTNSVDHLTTAIE
                     NGFAYAVVNAPVIIADGLYSRNYENVKIDKKHFESVKIGGEIYNSSAMIVMSHFKGHE
                     AAGFGGALKNLAMGCASAAGKQMQHSDVTPVVKEKKCVGCGKCVNSCPTKAISIVDKK
                     AVIDSDVCYGCGECPTVCPTRAVTIQWESDSDVFVEKMAEYAYGAVSNKKDKVGYITF
                     VMNVTPLCDCVPWSGRPIAHDIGILASTDPVAIEQACYDLICKEMGHDVFKHEHPHVN
                     GTRIIDYACEMGMGSKEYELIKL"
     gene            complement(21181..21939)
                     /locus_tag="KR257_002120"
     CDS             complement(21181..21939)
                     /locus_tag="KR257_002120"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421051.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBH0030806.1"
                     /translation="MREYIAFTKKEFKENLRNYKLFSLIILFLIFGISSPISAKFMPD
                     LIAHFAPTLKVTAAPTALDSWTQFFSNISGLGMSLTLIIFCNILSNEYSKGTLVIMLT
                     KGLSRSSIVLSKFSVTVIIMTIGFWLSFLFAYGYTMYFWPTANLNHIIFSAFNLWLIG
                     IMYISVLILGCVLFRPAFASVLLVLVATLLLSLISIPKQIAPYTPNFLMSKNIDLISG
                     KVAMPEFIIPIIITVLISIVCLLAAVILFNKKPV"
     gene            complement(21936..22853)
                     /locus_tag="KR257_002121"
     CDS             complement(21936..22853)
                     /locus_tag="KR257_002121"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009901777.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBH0030807.1"
                     /translation="MNIVSINGLSKGFGNRKIIDNLNFTVPEGSVFGFVGKNGAGKTT
                     TMKMVLGLLKPDSGTIDVCGEKVTYGKTSSNRHVGYLPDVPEFYNYMRPLEYLSLCGE
                     ITGLSKKEIQIRSEELLSLVGLRNEKRRIGGFSRGMKQRLGIAQALLSRPKLLICDEP
                     TSALDPVGRKEILDIMLKIKDSTTVIFSTHILSDVERICDHVAILNKGSIALSGTLSE
                     IKSMHGKDRLLLEFASNDEIQKFKSSDGIKSLLKDSEETNMEIVLHGKDIKAIQKTVI
                     STLAEMNLCPVKMELIELSLENLFLEVVK"
     gene            complement(22853..23053)
                     /locus_tag="KR257_002122"
     CDS             complement(22853..23053)
                     /locus_tag="KR257_002122"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421047.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PLDc_N domain-containing protein"
                     /protein_id="HBH0030808.1"
                     /translation="MENLMEYLPLLVPVIILDLILIITALVHVLRHPNYKIGNKAIWI
                     IVVLFISLIGPILYFTIGRGEE"
     gene            complement(23058..24152)
                     /locus_tag="KR257_002123"
     CDS             complement(23058..24152)
                     /locus_tag="KR257_002123"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425158.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HBH0030809.1"
                     /translation="MNELNIAKTLILKRKEKGITQDELANYIGVSKASVSKWETGQSY
                     PDITFLPQLATYFNITVDELICYEPQMMKEDINKLYNKLCKDFTVKPFDEVMDEIREI
                     IKKYYSCFPLIFRMGLLIVNHYDIVDEKKRELLISEALEIFIRIQETCNDIDICRQAK
                     SMEATCYILLNQPIQVIDLLQNSNFPMINESILLAQGQMMNGQMDEARETFQLGAYQN
                     LISLVQNLVGILQNADKLQMKEIERRILAISDIFELDTLSPAIMLSSYLTQAQINLIH
                     GDNEGAIKSLRKYVDLATRDIYPIIIHGDDFFNKLDRWISEIGTGITRDDTIVKAGIV
                     AAIKNNPMFSVLSENKEYKFLIEKLSLLEE"
     gene            complement(24662..24802)
                     /locus_tag="KR257_002124"
     CDS             complement(24662..24802)
                     /locus_tag="KR257_002124"
                     /inference="COORDINATES: protein motif:HMM:NF021468.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF2185 domain-containing protein"
                     /protein_id="HBH0030810.1"
                     /translation="MNGEGCILSNKITKECYKVGYMIREKSIDIYPDSGWGFMTWDEN
                     GE"
     gene            complement(25112..26419)
                     /locus_tag="KR257_002125"
     CDS             complement(25112..26419)
                     /locus_tag="KR257_002125"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729132.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="M20 family metallopeptidase"
                     /protein_id="HBH0030811.1"
                     /translation="MDISRSVDNSLNRTIEFLKELIKIDSQQGEPISQCPFGIGPKKS
                     LDKTLDYCASLGFSVKNIDNYIGYAEIGEGEELIGIPMHLDIVPPGEGWSVDPFSGAV
                     IDNIIYGRGVIDNKGAVSMLIHVLKNIEDMYPTINKRIRLIFGTNEETGMKCIKYYLD
                     KGEEIPSMGFTPDAMYPVVNGEKGRVHIRIEKEIKIDKSKPYIIVSGGTKENVVPSHC
                     TAKIINGIISELTTKGVAVHASNPEKGENAISKMVIKIVEDNMDFQHREDIELVSKYL
                     CSDYYGDALGINQYDEVFKNTTLNLGILKVNEEKIVCELDIRYGKNIVLNNIIDRFKK
                     VFCNGWKIEVIVHKDLHYVDESNLVLKKLLEAYEEVTDENGYTIAMGGGTYASWFKDM
                     VAFGPKFLAYKTGGHGVDERVPINHIRKNMEIYTLALIKLLEL"
     gene            complement(26484..26963)
                     /locus_tag="KR257_002126"
     CDS             complement(26484..26963)
                     /locus_tag="KR257_002126"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729131.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="L-2-amino-thiazoline-4-carboxylic acid
                     hydrolase"
                     /protein_id="HBH0030812.1"
                     /translation="MSEKMYTEKEYLEGIRGATGERAVWFYLLMKEAEKLGANPDDIC
                     KEAIYGFGKMRGQKYNVADTPGKMAEMLYNSKGQKVFEMELVENTDENGVLKFHHCPL
                     DAAWKEYGLTKEERKEICRLACYGDYGRVDCAQGVKLDFAQKCAHDDEVCELVFTKK"
     gene            complement(27010..27873)
                     /locus_tag="KR257_002127"
     CDS             complement(27010..27873)
                     /locus_tag="KR257_002127"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425164.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS system mannose/fructose/sorbose family
                     transporter subunit IID"
                     /protein_id="HBH0030813.1"
                     /translation="MQEIKNKEVKNGQGPTEVNKTRVLTKKDVTKTYLRWWWTAELSN
                     SFERMQALAVCASFTPALEKLYKRKEDLVDALKRHLQFFNTQAIWGGLIHGTVLAMEE
                     EKATEGKIPGEVISGVKNGLMGPLAGIGDTLDFGTFQTIFLALGASFGAEGSVIGAFF
                     PIMFSILLFCEGYYLFHLGYSLGRDSIKKILSGGIVNKIIDGASILGMFMMGALSATT
                     VKLSTPLSFDIGGKAIVVQDTLNMIAPGLLPLGVVFFVYWGMKYKKWTITKLLVILVV
                     LALVGSFIGIF"
     gene            complement(27873..28628)
                     /locus_tag="KR257_002128"
     CDS             complement(27873..28628)
                     /locus_tag="KR257_002128"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425166.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIC"
                     /protein_id="HBH0030814.1"
                     /translation="MESVLMLAIVTGLWYWFAAGLAGYTLFSTLKSPLFIGFSLGLLW
                     GDVTTGMIVGASIEMVYLGMVAAGGNIPSDKCLAALIAIPVALQTGVNAEVAVSIAVP
                     LGVIGVLVNNLRRTGNAVLVHKADKYAEEGNTKGIWRCATLYSLIFGFVLRFPIVFVC
                     NFFGADLVQSLLDVIPQWLMNGLTVMGGILPALGFATTIFTIGKNKFLPMFIIGFFMV
                     QYFEISITAAAIFGVCIALLITFMKEDKRVGEV"
     gene            complement(28655..29143)
                     /locus_tag="KR257_002129"
     CDS             complement(28655..29143)
                     /locus_tag="KR257_002129"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425168.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIB"
                     /protein_id="HBH0030815.1"
                     /translation="MAKITLVRVDHRLIHGQVITKWVKIAQAQKIIIVDDFLGQDEFM
                     ADIYKMAAPSGVEVVILTAEDAGQAFQNNTLGDKNIFILFKNVDMANKAYKAGLKYEK
                     IQLGGIPNEAGKKMVFTAVSLGNEDVEQLNELNENGVEIVLQVIPEESSMTYENALKK
                     FK"
     gene            complement(29161..29562)
                     /locus_tag="KR257_002130"
     CDS             complement(29161..29562)
                     /locus_tag="KR257_002130"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425169.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS mannose transporter subunit IIC"
                     /protein_id="HBH0030816.1"
                     /translation="MNKYKVIILCHGTWGKVLVEETNKNFGLSNQYEVLSLSSEKDVS
                     VFMKEVEEVVDKEDVKIIISDLYGGSTSSVAIAVAIRRGIDAINGLSLQTILIVDEEL
                     SKEDKLHTLPERIVKKNNNLCVDLIKEFKKI"
     gene            complement(29565..30062)
                     /locus_tag="KR257_002131"
     CDS             complement(29565..30062)
                     /locus_tag="KR257_002131"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421032.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIB"
                     /protein_id="HBH0030817.1"
                     /translation="MSLVKYCRCDDRLIHGQVIYKWVKHLGVKKIVVVDDETTNDVIA
                     KGLIKMAAPKNIDLSILTVSESRRYFYNNQADDNVFVLIKNLDTANRMIEEGINIKKL
                     IVGRIPTGIGKKKISQNVYINKKEFLLIDEFIKKNINVSIQMVPDEEEVELNQNINRY
                     KGEFI"
     gene            complement(30086..30490)
                     /locus_tag="KR257_002132"
     CDS             complement(30086..30490)
                     /locus_tag="KR257_002132"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421030.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIA"
                     /protein_id="HBH0030818.1"
                     /translation="MIGIIVMTHGSFSEEIIKSCELIAGPAERTAAIKLNRNDNIEDL
                     NKNFVEKLNELDEGDGVLVLADLLGGSPSNVASLNLKKGGKFHALTGVNLPMLLEALI
                     NREGKSLEELAEACIEAGQTGINNINKVLSSM"
     gene            complement(30720..33287)
                     /locus_tag="KR257_002133"
     CDS             complement(30720..33287)
                     /locus_tag="KR257_002133"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425173.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sigma 54-interacting transcriptional regulator"
                     /protein_id="HBH0030819.1"
                     /translation="MTQKKLSRKEKVLICLKRLTEEHLNFNNGIRFGFDAEYIATEVG
                     INRSNASKELNQLIKESIIIKIKGKPVQYLYKESIESILGKKLNKGIFDNINSINEYS
                     ENDSIKDEYILESIKKENNIFNLVGCDGSLRSQIEQAKAAVIYPPKGLSTLIIGPTGV
                     GKSIFAEYMYKYSLTIKEDSDNAPFIIFNCADYSDNQQLLLAQLFGYVKGAFTGADKD
                     KYGIVHEANNGVLFLDEVHRLSAEGQEMLFLLMDKGIYRRLGEANKVHECRVMIIAAT
                     TEDPETAMLETFLRRIPVTIKIPSLEERGFQERMKLICYFFKEESVRIGVKLKVSKEV
                     IKAFILYKCKGNIGQLKSDIQLICARAFLDYMTYKRECVYVRLSLLPNNIRESLYGNN
                     RKEEFVQNFSFIGKDDIIFLPEEKDFESENLLIENKKYDLDFYGMIKETWNKLQQEGI
                     KESQIRSVIDGDIQKYSYNLMNTFIYNSSNQTAYNNIVNDSIATTVKYILQKHDKWSK
                     REGLDKLIKAIALHIQNLIERIKIGNIVKHPNKDEIMKERAYEYNIAKEILSNMSLMY
                     GVEFPEDEAIFLATFLYLSYVGLNEESIAILVIMHGESTASSMVNVANTLLDCNHAVA
                     INMGLEDRVQDILVQAVEIANKIDKGKGILILTDMGSILTFAKVIRDATGKEVKAIDM
                     VSTPIVIEATRKALTPEMTLEKLYFNIIESIKKHYGDMEVTYAEKDNGGRYFDRLLID
                     NISKTLTFLNGEKAYFILKEVINRISEHYSLVIQDELLVKFIFHCSCMIERVIIKESL
                     VYKSYEERISRNKELYLVIKESFKLVEETFDIIISDMEYANILDIFESQYDTDKFKS"
     gene            33453..34196
                     /locus_tag="KR257_002134"
     CDS             33453..34196
                     /locus_tag="KR257_002134"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729128.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphatase"
                     /protein_id="HBH0030820.1"
                     /translation="MNFLSDLHTHSIVSGHGYSTLLENINYCKENGIKILGTSEHGPK
                     MPGSPHRWYFHNIQNIPRIINNIIILRGCEANILDIKGNIDLEPFVIPRLDYLILSFH
                     EAVFSPNTLENNTKALINAINKHDNIEILGHLGNPNYPIDYELIIKLAIEKNILIEIN
                     NCSIKGVSRNGSSDNCKYIATLCKKYGAKIILTSDAHICFDIGNYEYSENILKEINFP
                     DELIMNYPKKLINHFHQKGKLLDVDYTNI"
BASE COUNT        11211 a         6341 c         3548 g        13501 t
ORIGIN      
        1 cttaaaaata attcgtcaat actttttaaa attatttttt aaaaatattt actttcttat
       61 attacataat ttattgaatg gcagtcatac tgttggttta gagtatttta acacacacat
      121 tttgttgtaa aaattacaac tattaatata atatatatac aatcataagt attataattt
      181 ttatgaatct aatttaaact taatataaac ttattaataa accttctatg tctaaatttt
      241 aaaattacaa tataaaagct ctacactaaa taaatacatt aaataaacat aatggataat
      301 gaatataaat ttatatatgc aaagcgctcc aataaaaagg taccaataaa gttaaaagaa
      361 acttattgat acctttcatt attacatact tcaatatata attataagtt ttttaaatag
      421 tatggattta catttatccc ttatctcata gctctcatag catttactac tgctataagt
      481 gccacaccta catcagcaaa tatagcttcc cacatagtag ctactcctcc agcacctagt
      541 atcataacta taatttttac tcctagagca aatattatgt tttgccacac tatcttatta
      601 gtcttgtttg ctatttcaat tgctttagat atcttgctag gctcatctgt cataagcact
      661 acatctgcag cttcaatagc agcatctgaa cctaagcctc ccatagctat accaacatca
      721 gcacgagcta atactggagc atcatttatt ccatcaccta caaacgctat tttctctttt
      781 tcagttcttc cttcatataa atcttctaat ctatctacct tttcattagg aagtaaattt
      841 gagtaaactg tatccaattc taattcttga gcaatatttt ttgctacttt ctcattatct
      901 ccagttaaca ttacaacttc ttttacccct atttctttta agcttcttat ggcattttta
      961 ctatcttctt ttacttcatc agagataact atataacctc tatatacttt atcaacagca
     1021 atatagacta ctgtgcctac ttctttagct gatgaataag atatattttc ttttttcata
     1081 agtttctcat tacctgctaa tataaaattg ccattatgct ttactctaat tccataagct
     1141 gctatttcct cataactgtc tattgtatct aaatcaattt ttttattata gtaacttaat
     1201 atggactttg ctattggatg atttgaattt acctccgcaa tagctgcata ttctaataat
     1261 tcttcttctg atataccttc aggatttaac ttagttacat tgaacacacc tttagtaagt
     1321 gttcctgttt tatcaaatac tactgtatct acacttctta aagcttctaa atagttactt
     1381 cctttaataa ggataccatt tttagatgca aacccaattc cactaaaaaa actaagtggt
     1441 attgataaaa ctaatgcaca agggcaagaa acgactaaga atatcaatcc tctatataac
     1501 caatcactaa atacctcacc tgagattaca agtggtggca caaatgctat taataaagca
     1561 gctattacta ctattggagt atagtatctt gaaaacttag atataaagtt ttctgtcttt
     1621 gattttttaa tgctagaatt ttcaacaagg tcaagaatct tagaaactgt tgattctcca
     1681 aaactctttg taacttcaat actcaataaa gcatttttat ttataacacc tgataagatt
     1741 tcatctcctt tttcaacttc tctcagcact gactctcctg tgagtgcaga agtatctaac
     1801 atagaaactc catctactac tacaccatct aatggtactt tttcaccagg ttttactact
     1861 attatatcac ctacatttac ctcttctggt gacaccacct taacttcaga attaactttt
     1921 agatttgcat agtctggtct tatttgcata agtgaagtta tagactttct ggatttacca
     1981 actgcaacac cttgtaaata ctctcctact ttatagaaaa gcataacccc tactgcttct
     2041 gataactccc ctattgttaa tgctcctact gttgctagag ccatcaaaaa gttctcatca
     2101 aatactcttc cttttgatat atttcttatt gctcttaaaa gcacatcacc acctactatt
     2161 acataggcaa ctataaatac tatattgcta aactgacttt cataacctgt agctgtttga
     2221 tatataccaa atatatatac aagtgctcca attataagtg gaattaattc tttcttattt
     2281 gtatcattta cagctcctga tttttcagta gttctccctt ttactttgtc agtagaccct
     2341 acttgtatat caagccctgg ctctgttgaa tttattattt cttttatttt atttataaca
     2401 tcatcctctt caaagttatt acttatattt actgtaagtt ttttatttac aaagtttaaa
     2461 ttagaagatt caacttcttt taatttagaa actttgttat taatctcttc tgcacaatga
     2521 gcacagttta atcctcctaa tataagctct tttttaattg atgttttact agctgcattt
     2581 tctttagaac ttatttgtat atcaagacct ggatctgttg aatctattat atctattatc
     2641 ttttctatag tagtatcctc attaaaactt tcctttatat ttactgtaag ttttttattt
     2701 ataaaattta aattggaaga tttaacttct tgtagtttag aaactttatt attaatctcc
     2761 tctgcacagt gagcacaatt taatcctcct agtataaatt cttttttaat tgaattattt
     2821 gcttccatat atattcactc ctctcattta tcatttataa gtctctctaa tatgatttaa
     2881 tccacaatca aatatctgac ttatatgact atcatctaat gagtaataca ctgtttttcc
     2941 ttctcttcta aactttacta atctagcctg ctttaatact ctaagttgat gagatattgc
     3001 agaatgagtc atatttaata aactcgctat atcacataca cacatttcat ttgcaaataa
     3061 tgcatataat atctttactc tagtagtatc cccaaatact ttaaataatt ctgctaaatc
     3121 atataacatt tcttcatctg gcatagttga tttagcctct gttactattt cttcatgtac
     3181 tatattacaa ttacaatcat ttatctcttc tctcattttt aatcctccat tattttaata
     3241 tatgaataac tgttcatatg ttcattatat gttatcattt ctaaatttgc aacaataatt
     3301 tttattaatt taatataaat agaatgcaca tattataaac ttttttaata tatatattat
     3361 tagaataagt ttttgtaaac ttttttatag ttttctagga ggtgcaagtt taatatgagt
     3421 aacaagaaaa aaaaggattt agatactagt tacatgcctt acttagaccc agcgaactat
     3481 gcagattata ttactaatga agaaattccc caagatgaat tgagaaatga ccctcaaatt
     3541 tctaatggtt atacaaaaat acctaataac cagaacataa ataacctata tcctaataat
     3601 gtaaatcatt atcctaaaag tagtaattct ccaaacaact tgcctaacac aaataataca
     3661 tccggaaata tgaattacaa tacatctgct acaaataata tgcctaataa catgaataat
     3721 aatacgggta tgcctaataa tatgtctaac aatatgaata gtaatatggg tatgcctaac
     3781 aatatgccta ataacatgaa tagtaatatg ggtatgccta acaatatgcc taataatatg
     3841 aatagtaaca tgggcatgcc taacaatgtg cctaataaca tgaatagtaa tatgggtatg
     3901 cctaacaata tgtctaataa tatgaatagt aatatgggca tgcctaacaa tatgtctggc
     3961 aatatgaata acaatatgta tggtaataca ggtatgccta ataacatgaa cagtaatatg
     4021 gggtataata tgaacaatac tatgggtatt cctaacttct catgtaatca aaatatgcct
     4081 cctaatgtac ttatgatgat accaggagtt atatgtcata atacaatgca aggtatgcct
     4141 gtagttatgc ctagtactat gcctcctaat atatatccta ctccttatgg ttctagtaat
     4201 atgtctgtac aaggtatacc acaagctact aatattgagg aatttgatga ggaagaaatg
     4261 taatatatat ttttttaagt aagttgtata aaacattaat aattgaccat aataataaat
     4321 gtattcctca taatattccc ccaatattat tataggtata gaaagttgac tgaatatgcg
     4381 cttattcggt caacagatat taacataatc taataagata aacatagaaa aagtcagata
     4441 aaatttaatt ttatctgact ttttcattta aaaatgctct cttgtgttgg tgattcagaa
     4501 tagtatggta ctcgtatttg agactaatat tggcaaacaa cataaagaaa aatataaatt
     4561 ttttataata aactgtataa aattttaata attgaccaca ataataaatg tattcctcat
     4621 aatattcccc caatattata gaaataaatt taagcgagat taaattcagt taatctcgct
     4681 taaataatgt ctaaatttat tattccaaaa aatcatcaaa atctaatgaa cctgattctg
     4741 caaaatcata taatgcattt tgctcaaaga aaaatttctc ttcaaattta atatagtcgc
     4801 tataattaga ttgacttatt tcattgatat aattgcaatc attttcgtta taagtaccaa
     4861 taaaaaactt atttcccatt aagtaatata tagctttcat atcattattt attatatata
     4921 cattttcttt tacatggtca ttattaaaat taaatctagt aaagaatata ccttcattca
     4981 tattactttt taacagaaat ggattttctc tataaaatac tcctgcaaat tcttcaggtg
     5041 aatttacact gtaaacactt acaaattcac ttttagaaat ctcatcaaat acctcaaaat
     5101 catacatagg ttctttatct gtcactaata gagaattaat tctaaaacca gtttcataac
     5161 acttacttat gcaaaaagca attttacata tataatatcc atcattatct tcatataaag
     5221 cttcacttat atatctgcct tgacctttat cacttaccac gtttttaagt aatgttccat
     5281 ttatattagt aatgtgcata tttgcaatct cgtcacttcc agaaaagtac tttaaacttt
     5341 ctctatccca tgctataaat ctcatggtca tatagtttat aaattcaact tcctcgtcaa
     5401 ctcttttaca tattttattg tataattttt ctatagttaa atctgtttta tagtttttta
     5461 taatatcaat atactcacat ttatctcctg gcaatagctt atcataataa agattcttat
     5521 taccaaaata agatactaaa aataaagatt catccttcgt taattcaact ctatctgaac
     5581 caaatcctcc catcaatctt tcttcttcca tataagcttc ttcttgtgtt gggttattta
     5641 aactcacata atccgctaat cctaatccct ctgcatctaa taaaaaatat tgacaaaagt
     5701 gattgttttc atcatctatc caatttatta taagacctaa actgcccata agtctagaat
     5761 ttgtagcctt tgcaaaatta aaattcatat agtcacatcc tttaaactct aaaatacttg
     5821 ttttttaata tataaattat tatacatata ttttaacaac ttagatacaa tttataatat
     5881 aatataagga aatgattaat tgaggtggtc ttatgaaaaa tatagcagct ttttttgata
     5941 tagatggtac tctttataga gactctctta tggttgaaca ttttaaaaaa ttaattaaat
     6001 acgatataat tgaccaaaaa aattggtata aacatgctag agacactttt atggattggg
     6061 ataaaagaca aggtaattat gatgattatc tattagaaat atgtgacctt tatgttgatt
     6121 cactaaaagg attagataaa acctgtatca actttacaag tgaccaagta attaaattaa
     6181 aagcagatag agtttataaa tacacacgtt caaggattga gtggcatcta aatcaaggac
     6241 acatagttat atttatatct ggtagccctg gatttcttgt tgaaaaaatg gcaaaaaaat
     6301 ataatgtaac cgattttcta ggaagtgatt atgtctttga aaacaatata tttacaggca
     6361 cagttattcc aatgtgggat tctataagta agaataatgc tataaacgat tttgttgtaa
     6421 agtatgattt agatttatca aactcgtatg cctatggaga tactaatggt gatataaata
     6481 tgctaaaaag agttggaaat ccaatagcaa taaatccaac aaaggaactt ttatctcaaa
     6541 tatcacttga tgaggaaatt tctaaaaatg ttgagataat agtagaaaga aaagatatta
     6601 tttattctct atctacagat gtaaatatag tggatattta atttatacta tctattttaa
     6661 aaacttatat tatatctaat atttatatct aacatataaa agctttgact aaaaatcaaa
     6721 gcttttatat gttgcactaa gaatatatta aatttagctt tatgctttaa tgtatattca
     6781 tatatatcat ttacacttat ctaaactaca atttcattaa aattaaatat aaaaatcaac
     6841 tattattttt taaatagcat ctttcttaat ctattattgt aataacctat aaaagaactg
     6901 taaacatagt catatactat aaaggctatc tcaaatgaac ctataataaa tatgtttatt
     6961 ggaatataaa ctattgttct taataaaaaa tacaatataa gtatcattat atttgcaaat
     7021 actaatttca taaaatactc aatatatata gacctatctt tttctataag atattttaca
     7081 ataccatata ttccaaaggt aagtgaatat acaatccatt gagacttact tgccatcact
     7141 ataaatccta aaactataga acctatataa aaagcaattc cactcttaaa gccccattcc
     7201 attattacaa ttgatactaa aagtgatgct aaccccataa taaacaatgt atttacagga
     7261 ataatgtttg taagagtcaa caatatcaca tttaatgcta ataaaactcc tccataagca
     7321 acttttatac tcatatttat catcctaaca acaagttatt aaatctccac caaaacattc
     7381 acaacatgaa tctaaacacc aaagtttagc acaattttca caacaatcgt cacctagaca
     7441 acaacagcaa tcatcacagc aacagcaaca acatccatct aaatcattac gtcttcttct
     7501 attataattg tcagccctat tgctataatc atttctatat tgtgtataac ttctaagtgc
     7561 atcactatat tcactatttt caggctccat aaattttgct ctttttaaga agtcttcacc
     7621 ttcttcataa tatcctatgt tcattgcaga aaaaccagtt aaataatacc actctgcaca
     7681 tttgtcagtc aaagttttta aaaaatcata tgctttttta aattcactat tttctatgaa
     7741 tgatcttgct ctcataaaat tttcattatt ataagtatta ctgtacattc tttccacctc
     7801 tactttctaa tatattaata tatcttaaat aaacaccaga ataaattata ttttctatta
     7861 ttccaacatt tttatttaga tttagattat caattcccct agctaaaaat cctaatgatg
     7921 ttactattat tttttttact ttttctttta actcatcatt tttatcaata tactctataa
     7981 atggattata tcttcctttc ttaaaatctt catctaaatc ttcataggca tctagtagat
     8041 atatatactt acctatatta aaacctatca ttcttaagtt tctctcattt tcatcttttt
     8101 tatagacaaa tacttcaccc attatatttc caaatatact agatacttca tctatattta
     8161 tatttttatc tttttctaac ttatttaatt catttagttg ttgttttata tactctgctt
     8221 tttcaggata cttttcatat gctaatttta atttgttttt atatatataa tatgccaatt
     8281 tatcttttat gcgtttatca tccattaaat tatcttccaa tttataatac gttaaaagaa
     8341 tattcatact tgctgcatat tctgtaatat catttgtaat tacctttttc tttttaaatg
     8401 gatttactat acacacttcc tctgtactta tagactctgg gttatatact gctgttaata
     8461 aaacaattaa aaatgttata tcatagttca aagaaaacct agagatttct ccatgatttc
     8521 tttttaagta tttacatagt ccacaatagt aagctttgta ataatcatat tctctaaatg
     8581 ttaaatccat tttgtttatt ttaacatatc caaacataaa tactcctttt tgtactattt
     8641 tttatttaga ttatatatag tataacactt tttatcaaga ttatataatt tacagtattc
     8701 taagaaactt aaaaaattcc ttctaatcat tgtatcttaa atttaaaata attagaaggt
     8761 tgggttaaaa ataatattaa attatatact tatattaact catacaagtt agttatgctt
     8821 atatcaattt aagttttaaa taattggtat atatttaaaa ctacctacag tatccttcaa
     8881 ttcttttttt gctttgttta taaccaattc atcaagcatt acatcattta ttgaacatga
     8941 tatagattta gatgccaata acattgcctt aaatcccata tcagaacctg cactggcaca
     9001 agattgccat gtatgggcag aaataccaat aggccaaact gaacaagaac actgtgctgt
     9061 aggaattatg tagctaacat ctccaatatc taatgataat gatatacagt tattatgagt
     9121 aaatgtatca tccgtaactt catcatgcag attcatctta gtaatatcct tatttccact
     9181 taatacacta gaaacactac ttcttttatc tatagacact gtctcagcta atttatctgc
     9241 aaaatagtag tcatcttcat tatagttttg cacacctact aatttcatat tttgtgatag
     9301 aatatctgtt aatattgtat ttggaatata gtcatatact ccacttataa tgtcatattc
     9361 cataatagta ccagtcatta atgctgctcc ttttgctata tcaacaatcc taccaaatac
     9421 atctcttaca tgctccattt taactcctct tatgtaatac cacacttctg caaaatcagg
     9481 aactatattt ggcatttttc caccattagt agttacatag tgtactctac aattatcaaa
     9541 tatatgttct ctcaaataat tacaacctat attcataagt tctactgcat caagtgcact
     9601 tcttccgtta taaggagctt gtgctgcatg ggcactaatc ccattatatc taaatttcac
     9661 agagtaatta gcaagtgttg gtattcttat tggagtattt atatcaaatg gatgccaact
     9721 aaaagcacaa tcaattccat caaaaaaacc tttttttatc atcaatactt ttccagataa
     9781 atcttcttct gctggacatc catagtattt tatagtccct ttcagctttt ttagtttgat
     9841 taattccttt actgcaatta cagctcctat tgaacctgta ccaagtaagt tatgtccaca
     9901 tccatgacct gcaccaccat ctacaatagg ttctttagta gtggatactt tttgagacaa
     9961 accatctaaa gcatcatatt ctcccaaaac tgctataact ggtctacctt ctccataact
    10021 agccacaaat gctgtatcca taccttctaa tccctctata ctaaaaccat gtttttttaa
    10081 acattctttt tgtaaatttg aagcatagta ttctttatac tgaagttctg gatttttcca
    10141 tatcttatct gatatatctc ttaattctcc ctgtatctca tctatatatt ccatcaaaaa
    10201 ctttttattt aaattatcca tattaattat ataaacctcc ctgtttctaa taacttatcg
    10261 attatcagcc aaaatgacta attttaactg atttaaaaat attttctacc atacaaccat
    10321 tttatacaat aaaacctctt gacttgtaag tttcatttta tcaagtaaga ggttttcaag
    10381 ttttataaaa tttttagcat gttaaccaat caagcatatt aacccataat ttattatagt
    10441 atttccaatc agtaaattct tttggacccc agtgaggtgc acagtcagaa ctaaagatag
    10501 cagattttcc ttttccaaac tcgccaacag ctacaaatgg gtctcctcca atagttgcta
    10561 aaacaggaca attatctcta gctactgttt tgttatatcc taaaaacttt ggccattctg
    10621 ttggtatacc ttttaatact ggatgttcag agtcaataac ttctggaatt attcctgctg
    10681 gtttttcaac tctatcatct ttatctatca ttgttattgg taatacatct ttgatagcag
    10741 tttctccaaa tctagctttt gcatctattc ctgtaaatga catatatcca cctaccatga
    10801 ttaacgcccc accattattt acatactctt tgattagttc aagtctatct ggattactat
    10861 tgcaatctat aaaagtacta ttagataata agaacgtatt agaacctata tcagataata
    10921 ttatacagtc atactcattt aactcttcta atttatacgg aaaactatct gctgctacat
    10981 gtgcaggcat atgaactgtc tcatatcctc cagattctat tgcttctttc aaccacttta
    11041 cagcttcttc ataatgagtt gtaacaaacg tatcaaaccc ttttatatga gttatatttt
    11101 ttacccaaga ttcccctact attaatactt ttttcattta tatattcctc ctacttttat
    11161 aagtttaata ttagacttgc atacataagt atactatcta aatactcctt aatttcaaca
    11221 tattcatcaa ttgaatgaca ttgttctatt gaacctggcc ctaatataag tgttggtatt
    11281 tcagctaaat ttttcattac tctcgcatca ttgccagctg ttgaaccttt tatctctaat
    11341 ttttttccta gagtttcttc tagtatttta tgtgcattca ctacaaaatc agaatccttg
    11401 tccatctcaa aacctaaccc tgattgatat atgtttatat ttggtttatt atctttaagc
    11461 cataaatctc cattagccct tgtcattatg acatttgtta catcatttac aacttgttca
    11521 taactcatta tatttggcaa gaagtgtaca cataaattaa atacacactt atctggcaca
    11581 gtagaacctg ctgttccacc atttattaca cctaaattta ttgtaggtga aggtaatagt
    11641 ggatgtttat atatcataag ccagttatgt tccaactctt ttatatcttg aagcaacaac
    11701 atagccttct caattgcatt tacaccctcc cacttactac cacagtgaag agacacacct
    11761 ttaacctcaa cttcaaagaa tacaaatccc atatgtgcaa ctattaagtt ttgttctgat
    11821 ggttcacaaa ttatgcaaca atctccatca ataccattca taactgcatt tatggtacca
    11881 tttccgccac cttcttcatc tactactgac attattttta cattaccagg tacatttaga
    11941 ccactatctt ttataagctt tacagctaat attgatgcta taagtccaga tttcatatca
    12001 gcagttccaa gaccataaag ttttccatta tcttctgtag cacgatatgg attatatttc
    12061 cacttactta tatcacccgg tggcatagtg tctacatgac cattaaatac aattgtctta
    12121 ccaggtaaat catcactata cttacaaatt aaattatatc tatcttgata attgtgacct
    12181 agatttcctt ctttatatat attttttgct tttttaatta attcttcgct catttcttgt
    12241 ctatccacac taaaacctat gtaatttgca agtttttcaa tatattcctg tccttctttt
    12301 tcaaatccac ctagtattcc atgaccaaca tcttcagtct ttatacttac aagttctttt
    12361 aaataatcta tgtattcttg ttttttacta tttaatgtat ctaagagaat ttttttcata
    12421 tttcctccta agatttattt ttacatttaa aatttcaagt ctaatctcat ctatttaagc
    12481 catagtaaac tttttcactt agcatattct cattcaatgt ataaagatgt atgcaaatta
    12541 aagtataaaa atatatacaa aaacttaata atttttatag tttataagct aaaatttaat
    12601 tactatttag atttagctga tttttttaat tttatattat ttatccatat agcaaataac
    12661 attaccaaac cttttataat catttgatta tatgaagata cacttaataa gtttaatcca
    12721 tttcctaata ttcctattat tccgacacct atacatgtac ctactataga accagaacca
    12781 cccatcatat tagtaccacc aagcacaacg gctgctatag catccaattc tgctccatct
    12841 ccaacagttg gtgaacctga tgccaaacgt gatgatagta ttatcccagc taatgctgtt
    12901 agtagtccag ctagtgcgta tacttttact ataactttat ttacttttac tccacataat
    12961 ctagcggcct cttcatttcc acctactgca tgtacatgac gtccaaaatt agttcttttt
    13021 aatagaaaat gtcctgctat tacaactata atcataatta taactggtat tggtattggt
    13081 ccaatatatc ctctaccgag catcttaaat gcatctgtat ttactgatat aggtcttcct
    13141 cctgtaaata caaagcttgc cccacttatt atcgttaaca tggctaaagt tacaatgaat
    13201 ggaggtagtt tttgtgttga aataattgca ccttttatga ctcctaatat tgtccctatt
    13261 gctaatgcaa gtatcatacc tacccatata ggtgcattat aattcactac tgttgtagcc
    13321 caaaatgtac ctactaaagc aattactgct cctacactta aatctattcc tcctgtaatt
    13381 attacaaatg tcatacctac tgcaagtatt gcatttattg atatttgtct tccaacatta
    13441 attaaattat ctaaagttaa aaagttagat gaagctacac tcattattat aaaaattatt
    13501 acaagtccta cagctgcact cccttggtct ctaaatacac ttgttaattt tgtcaataat
    13561 ggagaagatt tttcttcttt atgcttagtt attgaactca ttaattttac ctccgaaagc
    13621 caattttaat acattatttt caaccatttc ttcaccttct aaaaatccac ttatatgacc
    13681 ttctctcata accattattc tgtcactcat tgatattaat tctggtattt cagaagatat
    13741 cattattata cttacaccac tctccactaa atctcccatt agattgtata tctctgcctt
    13801 agcatttaca tctatacctc tggttggttc atccataatc aatatatctg gttgtaataa
    13861 aagccatctt gctattatag ctttttgttg gtttccacca cttaaacttt gtataacttg
    13921 attcatatgt ggtgttttta tctttaaagc ttctatgtat ttttctaaaa tctctttttc
    13981 cttttttcta tctataattg atttaaactt agatatcttt tttaacccag ccatagttgt
    14041 attttctttg acactcattt gtaaaaacaa tccagtacct tttctatctt ctgttattaa
    14101 tcctagtcca ttttctattg catctgatgg agttttaaac tttacttctt cattgtttaa
    14161 atatattttt ccagaatcat atgttctaag tccaaatata gcttctacta tttcacttct
    14221 cttacttcca actagtccac ctattcccaa tatttcacct tttcttatat taaagctaat
    14281 atcattaaaa acattgttct tagttagatt ttccactcgc ataatttctt cttttatttc
    14341 tacttttctt tttgggaaaa attggtctag ctttctatct atcattaaat taactaattc
    14401 ttcctcagac gatacatctt tggtatttaa agtcgaaatc gttttcccat ctcgcattat
    14461 agttattctg tcacaaatct caaagagttc ttccatccta tgggatatat atattatact
    14521 aactccactc tcttttaaat catttataag tctaaaaagt atttcagtct cttttttact
    14581 tattgaagaa gtaggttcat ccattattaa tactttagtt tctgatgata aaactcttgc
    14641 tatttctacc atttgttttt gagctatact aagctctttg actaaactat ttggatttat
    14701 atctattccc atattatcga aaatcttttt agcctcttca ttcatttttt tgtcattggt
    14761 taagactttg ccatttattt cttttcccat aaaaatattt tgtgctactg ttaattcgtc
    14821 aaaaactgtt agttcttgat atatggcatt tatacctatc tttttagaga tatctgggga
    14881 tatattctct atttctttgc cttcaaaaat aaattttcca gaagttttcg aatgtgcacc
    14941 agttaaaatc tttatcattg ttgatttacc agcaccattt tcacccagta gtgcatgaac
    15001 ttcgccatga aataactcaa aattaacatt atctaatgct ctgacaccag gaaattcttt
    15061 agcaatatta cttaacttca gaattatatt actcataatg acactccttt ttaaatagga
    15121 tttctttcaa ataatctcat tttattttac taattcttaa agtcttttat attttcctta
    15181 tcataaagta aagctggtac tggtatattc ttttctacct tttccccttt tatagctttt
    15241 actactgctt ctacagctaa acgtcccatc tctttaggtt gttgttgaat catagcaaga
    15301 atagttccat ctgttattcc acttgatgct tcttcagtta agtcaaatcc tacaatctta
    15361 acatccttat tttttgcaga ttcaagtgca gctttagctc ctagtacact attttcagct
    15421 gttgcatata ttatatctac atctggatta gattgaatta agttttctac tgtattaaga
    15481 gattcttctc tgtcatatcc tggttgtgaa tttaatatct taacatttgc tgaacctttt
    15541 aatgcatctt taaatccatc tattctctgc atttgtattt gagattttaa atctgtcact
    15601 attgctattt ctgactttcc acctaacttt tcatctatgt attttttagt gtattcccct
    15661 aattttttac cagcatcata actaactgtt cctacataac ttgtaatatt ttcagtattt
    15721 aatacagcat ctactgtaac tactggcatt ttttcaaatg ctccttctac tgctggtact
    15781 atagccgaat tatcagttcc aagtactatc attccatcta cattttgttg tataaaatct
    15841 tctattgctg atgtttgctt agctacatct tggtctgggt catttactat aactttcaca
    15901 cctaattctt tagctttttc ttttattccc tcatcaatat ctataaaaaa ttgatgttga
    15961 agagttattg tagatactcc aatagttaaa tctttcttgt ctgaaccacc tttattatct
    16021 gatttacttg gtccttccat tgaacaccct gttaacattc ctattgctag tattccagca
    16081 attcctaaag ataaaatttt tctcactctc ataattaacc tccattttta atagttttaa
    16141 atttgaacaa attagatttt tatttattat ttaaatattt ttcaacatct tctttataag
    16201 gcataccaga ttgtgcacct agtttagtta cagacagacc tgatactact actgcatatt
    16261 ctactgctgt atataaattt ttcccttctg ttatagccac tgccaatgct ccattaaatg
    16321 tatctcctgc tcctgtggta tcttgaacat caacacttat acaagataca tgcttgattt
    16381 cctcaccatc ataaaatcta gctccatttt ttccttctgt tattacaagt ttatttggat
    16441 atttttttaa tacttcttct atcccttcat ttgtgtcaaa aactatctta tattcatgtt
    16501 catttggtgt taagtaagtt actttttcta ttatatcttc atttagtttt actgctggtg
    16561 ctggatttaa taaaacccta atcctatttt caaaacagaa attcactaca taatttattg
    16621 tttttaatgg aatctctaat tgtagcaata ctatatctgc attctttatc tcttcttcat
    16681 tctttttaat taattctata tctactagct cattagtccc tggtacaaca acaatactat
    16741 tatcattttc acataatgtt ataacagcaa caccagaact tttgtgatta tttctggata
    16801 ctaagctata atcaacttta ttcgttctaa aatttcttat taactcctct cctaagccat
    16861 cttcccctat gcatgatatc atttttacat ttgctcctag tttagaagct gagatagctt
    16921 gattagcccc ttttcctcca ggtgatgtaa aaaaactatt acctaatact gtttctcctt
    16981 tttctggtct tttatctaca gaacatacca tgtccatgtt tacacttcct atgacaacta
    17041 tgtttcccat tacattactc ctttacatat ctatttatgt ctctcgtgct gttattcact
    17101 ttcttttgtt gaatctctta tgaccaattc tggtttgaaa atcaattcat caaacgattc
    17161 ttttttatct cctcttaaac aatttatcaa tatttcactg gctttatatc ctatatcata
    17221 agacggctgt tttactgtgg taagagaagg gcttattaga cttgatgttt gaatatcatc
    17281 aaatcccacg acacttatat catttggtat acttaatcct ctttctttaa gacctcttat
    17341 gacacctatt gcaatcaaat catttgcaca aaatattgca tcaaaatcta tcttttctaa
    17401 attttttata aattcttgtc cccattcaat cttatatttt ccttcaaata cataagcagg
    17461 attgtagctt aaattgcact cgattagagc ctttttatat ccttctaatc tatctactgc
    17521 tatttcattt tgaagtggac cacttaggta tattattttc ttatttccaa tatctaataa
    17581 atgttttgta gctatatagg ccccttcaaa gttatttatt ttaacaattc cttttaaggt
    17641 ttctttgttc atacttatct tcttatcaat caagacagtt ggtattttta tatctttata
    17701 atttgcttct ttccagtttg tatttgaaga tgctgcaaat ataattccat ctatcatcct
    17761 ctctgatagt gttcttattc cttcatattc ttttttagca tcttcatctg tattacataa
    17821 aattatattg tagccttctt cattagcttt gtcttctaca cctcttgata catctgtaaa
    17881 gaatggattt cgtatatctg gtataagaag ccctatagta ttagtttttt tagttactaa
    17941 actttgtgct aatttatttg gtacataatt tttttccttc attattttca aaattttttc
    18001 tcttgttgcc tgacttatat tttcatcttt attattaatg acttttgaca cagttgtttt
    18061 agaaacacca gccaattcgc caatttcttt tatagttata ctcaagaagt tcacccccaa
    18121 aatttaggaa accgttttac ttaaccggtt acctagatac tatcacatct tttttccatt
    18181 tgcaaccatt ttatataaat tttgatattt ttcccttttt tcaaaatatt gcaacttata
    18241 attcaatttt aatatttaaa ttaatctgaa aaaaaaatta atatactttt ataattatct
    18301 aaaagtatat taattaattt aagcagtatt tattaaagtt caaatccttg ctctataatc
    18361 atttttttat cattttcaat cccacttcca acagttgtca aataatcacc aacaattgca
    18421 gaatttactc ccccattaaa tccaactttg tcatatccct ttaatgatag ccttccacca
    18481 gcatacctta tgtacacatt aggaattata aacctaaata ctgctgttgt ttttagtatt
    18541 tccattggtt ctaatacatc ataattttcc attggtgtat tcttaatagg atttaaaatg
    18601 tttattggaa atgattttac atttaattct cgtatttcaa aagccatttt tagtctctgt
    18661 tcttcactct cattcattcc aattataccg cctacacata catctagccc agctttttta
    18721 gcatctttta tagtttttat cctatcttta tatgtgtgtg ttgtacatat attatgaaaa
    18781 ttatctctac acgtctcaac attgtggtga tatgtagtca cacctgctga cttcaacatt
    18841 ttagcttgct cataatctat aatacctaaa gatgcacata attttaaatt agtattttcc
    18901 ctcaatcctt catagatatt taaaatatta ttaaactcct ttcctgacat acctttacca
    18961 cttgtaacca atgagaatct atgcactcct ttactctcca tctctttagc tctatttaag
    19021 atttcattgt aatctaataa tgaatattct tctacaccag ttttataata agaagactga
    19081 gcacaaaatt tacagtcttc actacatttg ccagatttag cattcattat cgtacataaa
    19141 tctgcttttc ttcccataaa atattctctt atttcatttg cagattttaa tagaatatca
    19201 aaatcgtttt tattatttgt atcaaggctt attaaattaa gagcttcttc ataacttatt
    19261 tctttttctc tcaatacttt attttttaat tttattatgt atttttccat atatcctcct
    19321 atttgtcaac ttaatatttt tatgtagttt acttattata tatagtattg catatataac
    19381 atttattggt caactttatt ttagacacaa gtttactata cacaaaaaaa tactgcttca
    19441 aaacaatatt agtatataga ttatacatat tattattaaa gcagtatttt ttattagaat
    19501 ataattctta ctggtttata aaactatcct tgtcttaact ccatccaagc tttccattgt
    19561 aataacttct aagccttcat attctctaaa tagccatttt aaatccttca tggcttgatt
    19621 aacctgactt tttgttagat tatttataaa atattctttt ctagtttcct catactcttt
    19681 gctagtcaaa aagtttctta gaaaattaaa cgcaaataca cttggaatat tgtttacatt
    19741 agccttcttg ctgttttcct tctcatagta aattttcata aatgcatact cctttgatac
    19801 ttttagattt ctcttacaat aattatatgc atttaagtgc tactattctt ataattttat
    19861 taattcatat tctttacttc ccatacccat ttcacatgca tagtctatta ttctagttcc
    19921 atttacatga ggatgttcat gtttgaaaac atcatgaccc atttccttac aaatcaaatc
    19981 atagcatgct tgttcaatag ctacagggtc tgttgatgct aatattccta tatcatgggc
    20041 aattggtcta cctgaccaag gtacacaatc acaaagtgga gttacattca taacaaaagt
    20101 tatataccct accttgtctt ttttatttga tactgctcca taagcgtatt ctgccatctt
    20161 ttcgacaaac acatctgagt cactttccca ttgtatagtt actgctctag ttggacagac
    20221 agttggacat tctccacatc cataacatac atcagaatct ataactgctt ttttatccac
    20281 tatacttata gcttttgtag gacaagaatt aacacacttt ccacaaccta cacacttctt
    20341 ttcctttact actggagtaa catcagaatg ttgcatttgt tttcctgctg cacttgcaca
    20401 tcccatagct aagtttttta atgctcctcc aaaacctgct gcttcatgac ctttaaaatg
    20461 actcattact atcattgcag aagaattata aatttctcca cctattttta cactttcaaa
    20521 atgttttttg tctattttta cattctcata atttctacta tataatccat ctgcaattat
    20581 tactggtgca tttacaactg cataagcaaa tccattttct atagcagttg taagatggtc
    20641 tacagaattt gttctactcc ctgtatacag tgtatttgta tctgttaaaa atggctttcc
    20701 ttcgcagtct ttaaccttat caaccacttg tctaactgcc acaggactca tatatgtagt
    20761 atttcccttt tctccaaagt gaagtttaat tgcgacttgg tcattttttt ctattaaatc
    20821 tttgaatcct gcttcatcaa ataatcttct tacattgttt ggtacgtttt tattttgcga
    20881 atttgagtat aaatcacaaa aatatacttt tgacttttcc atatctacac ccctttaaaa
    20941 tatttactta tactaatttt atcactttta aagtaatttt tagtatattt taacataatt
    21001 aaatattctt atatttattt gatacaaata atattatttg tattattttc tacacttaat
    21061 tctatatatt aaactacacc taaaaatcaa aaagacttga aacttaagtc caagtctttt
    21121 tgatttttag gtgtagtttt taacaacata agattacttt accttgtgat aaaggtatta
    21181 ttaaactggt tttttattaa ataaaataac agctgctagt aaacatacta tagaaataag
    21241 aactgttata ataattggaa taataaattc tggcattgcc actttccctg aaatcaagtc
    21301 tatatttttt gacatcaaga aattaggagt ataaggtgca atctgtttag gaatagaaat
    21361 taaactcaat aagagagttg ctaccaatac aagtaaaaca ctggcaaatg ctggtctaaa
    21421 tagtacacac ccaagaatta atacactaat atacataatt cctataagcc ataaattaaa
    21481 tgctgaaaat ataatatgat taagatttgc agttggccaa aaatacattg tatagccata
    21541 agcaaataaa aaactcaacc aaaaaccaat tgtcataata atcaccgtaa cagagaattt
    21601 agacaatact atagatgaac gtgataaacc tttagtcagc ataataacaa gtgtcccttt
    21661 agaatattca tttgataaaa tattacaaaa aataattaga gttaaactca taccaagacc
    21721 agagatattg ctaaaaaatt gtgtccaaga atctaaagca gttggtgcag cagtaacttt
    21781 taaagtcggt gcaaaatgag caatcaagtc tggcataaat tttgcagaaa taggactact
    21841 tataccaaat attagaaata aaataattaa actaaataat ttataatttc ttaaattctc
    21901 tttaaattct ttttttgtaa atgctatgta ttctctcact ttactacctc caaaaataaa
    21961 ttttcaagtg ataattctat tagttccatc tttactggac aaagattcat ttctgcgagc
    22021 gtagatataa ctgttttttg tattgctttt atatctttac catgcaaaac aatttccata
    22081 ttagtttctt ctgaatcttt tagtaaggat ttaataccat cactagactt aaacttttga
    22141 atttcatcat tacttgcaaa ctccagtaaa agtctatcct ttccgtgcat actttttatt
    22201 tctgaaagtg taccactaag ggcaatgctt cctttgttta atatagcaac atggtcacag
    22261 attctttcaa catctgatag tatatgtgtt gaaaatatta cagttgttga gtctttgatt
    22321 ttaagcataa tatctaatat ttcttttcga ccaacagggt caagtgcact tgttggttca
    22381 tcacaaataa gtaatttggg gcgtgaaagc aaagcttgag ctataccaag tcgttgcttc
    22441 attccacgag aaaacccacc tattcgtctc ttttcatttc taagacccac aagtgataac
    22501 aactcttcac tccttatctg tatttctttt tttgaaagtc ccgtaatttc accacaaaga
    22561 gaaagatatt caagtggtct catataattg taaaactctg gaacatcagg cagataacct
    22621 acatgacgat tagaacttgt tttcccatag gtcactttct caccacaaac atctatagtt
    22681 ccactatctg gtttaagtaa cccaagtacc attttcattg ttgtagtctt acctgcacca
    22741 ttcttaccta caaacccaaa gactgaccct tctggtacag taaaatttaa attatctatt
    22801 atctttcgat taccaaaacc ttttgataat ccatttattg agacaatatt catcattctt
    22861 cacctcttcc tattgtaaaa tacaaaattg gtcctattaa actaataaac agtactacaa
    22921 taatccatat tgccttattt ccaattttat aatttggatg tctcaacaca tgaacaagtg
    22981 cagtaattat aagtattaaa tctaaaataa taacaggaac caaaagtggt aagtattcca
    23041 tcaaattttc cataatctta ttcctccaat aaagataatt tttctataag aaatttgtat
    23101 tctttgtttt cacttaatac agaaaacatt ggattatttt taatagcagc aacaatacct
    23161 gcttttacga ttgtatcatc acgtgtaata cctgttccaa tttcagaaat ccatctgtca
    23221 agtttattaa aaaagtcatc cccatgtatt ataattgggt atatatcacg tgttgctaaa
    23281 tctacatatt ttcgtaatga tttaatagct ccttcattat caccatgtat taaattaatt
    23341 tgtgcctgtg ttaaatatga agaaagcata atagcaggag ataatgtatc aagctcaaat
    23401 atatctgaaa ttgctagaat acgtctttct atttccttca tttgtaattt atctgcattt
    23461 tgcaaaatac ccactagatt ttggactaat gatataaggt tctgatatgc accaagttga
    23521 aatgtttctc ttgcttcatc catttgacca ttcatcattt gcccttgtgc aagaagtata
    23581 gattcattta tcatgggaaa attgctgttt tgcaataaat caatcacttg tatgggttga
    23641 tttaacaata tataacaagt tgcctccata ctttttgctt gacggcaaat atctatgtca
    23701 ttacaagttt cctgtatacg aataaatatt tctaatgctt cactaattaa tagttcacgc
    23761 tttttttcat ctacaatatc atagtgatta actattaaaa gacccatccg aaaaatcaaa
    23821 ggaaaacatg aataatattt ttttatgatt tctcttattt catccatgac ttcatcaaat
    23881 ggtttaaccg taaagtcttt gcacagttta ttatacagtt tattaatatc ttccttcatc
    23941 atttgaggtt cataacatat taactcatca acggtaatgt tgaaatatgt cgcgagttgc
    24001 ggtaaaaagg ttatgtcagg atagctttgt ccagtttccc atttagatac agaagcttta
    24061 gaaacgccta tataatttgc aagttcatct tgtgtaattc ctttttcttt acgctttaaa
    24121 atcagcgttt ttgcgatgtt taattcattc atgtcaatcc ctccttatgt ataattatat
    24181 ccttaaacat gtaaagctaa caagcgattt gaagttgact tttgacgaaa aaatcaacca
    24241 cagagaaaca aataaacaag tatataaaat atatatttaa atttatcttt aatctccttt
    24301 gtaaaatatg taaactttgt aaataaaatc catattatat aaaactaata gttaatctat
    24361 ctaaatacag tttttattta tcacgttttt aaatattttg tgtaaaacct cttttaatat
    24421 aaacacctta ttttcatttc tcatttcata ttctttttaa aatactgaat ataactcttc
    24481 gattttccat ttaatccttt tataaagtta ttattcgtat ttattcctct aattataaca
    24541 ggcaactatc atgtattggt atttgtctat tatataaaaa tctataaaag aaaagcagtc
    24601 aatcatttag attaactgct tgtacatata tcttattaaa ctgtataaac tataattttt
    24661 attattctcc attttcatcc caagtcataa atccccatcc actatctgga taaatatcga
    24721 tagacttttc tctaatcata taaccaactt tataacactc ttttgttatt ttattagata
    24781 gtatacatcc ttctccattt atctaattcc atttaattaa cttttctttt caaccttaac
    24841 ttttataaaa tcatcttttt taataatttc atacttattt tctcttcaac atcatcaaat
    24901 gagggtgtct caaaattaac tttttacttc ataaggcact cttttttgta tgaagtaaaa
    24961 tatattttca tcatttcaac aataagtaag aggcttatct ctattttgag acagccccat
    25021 ttgatggtgt tgaacattta aataaggttg aactcgtttt atctctcttt ttaagatatc
    25081 tgtaaatttg cacataaagt ctcttcttct tttacaattc taatagtttt attaaagcca
    25141 aagtatatat ctccatattc tttcgtatat gatttattgg tactctttca tctactccat
    25201 gaccaccagt tttatacgct aagaacttag gtccaaacgc caccatatct ttaaaccaac
    25261 ttgcatatgt gccaccaccc atagcaattg tatatccatt ttcatctgtt acttcttcat
    25321 aggcttctaa taatttttta agtactaaat tactctcatc cacataatgt aagtctttat
    25381 gaacaataac ctctattttc caaccattac aaaaaacctt tttgaatcta tctattatat
    25441 tgtttaaaac tatattttta ccatacctta tatctaactc acatacgatt ttttcctcat
    25501 ttacttttaa tattcctaaa tttaaggtag tgtttttgaa tacctcatca tattgattaa
    25561 tccccaatgc atctccataa taatcactac aaaggtattt tgaaactaat tctatatctt
    25621 ctctatgctg aaaatccata ttatcctcaa ctatctttat taccatttta gatatagcat
    25681 tttctccctt ttcaggatta cttgcatgta cagctactcc tttagtagtt aactctgaaa
    25741 taattccatt aataattttt gcagtacaat gagatggaac aacattttct ttagttcctc
    25801 cacttactat tatgtaaggt ttacttttgt caattttaat ttctttttct atccttatat
    25861 gaacccttcc tttttctcca ttaaccactg gatacatagc atctggagta aatcccatac
    25921 ttggaatttc ttcaccttta tctaagtaat atttgataca tttcatacct gtctcctcat
    25981 ttgtaccaaa aattaatctt attcttttat taattgtagg atacatatcc tctatgtttt
    26041 tcaatacatg tataagcata gatacagcac ccttattatc tatgacacct cttccataaa
    26101 taatattgtc aattactgct cccgaaaatg ggtctacact ccacccctct cctggtggaa
    26161 ctatatctaa atgcattgga atccctatta attcctctcc ctctccaatt tctgcatatc
    26221 caatataatt atcaatattt ttaacactaa aacctaaact agcacagtaa tctaaagttt
    26281 tatctaaaga ttttttaggt cctataccaa aaggacattg tgaaataggt tcaccttgtt
    26341 gtgaatcaat ttttatcaat tcttttagaa attctatggt tctatttaaa ctattatcta
    26401 cacttctgct tatatccata aatcaaccta ctttctatct ttttaaagcc tgtccttaaa
    26461 gaacaggctt ttagcattaa aaattatttt tttgtaaata ctaattcaca aacttcatca
    26521 tcatgagcac atttttgagc aaaatctaat ttaacacctt gtgcacagtc aactcttcca
    26581 taatccccat aacaagctaa tctacaaatt tcttttcttt cttctttagt taatccatat
    26641 tctttccaag cagcatctaa tggacagtga tggaatttta aaacgccatt ctcatctgta
    26701 ttttctacta attccatttc aaacactttt tgtcctttac tgttatataa catttctgcc
    26761 atttttcctg gagtatctgc tacgttatat ttttgacctc tcattttacc aaatccatat
    26821 attgcttctt tacatatatc atctggatta gctcctaatt tttcagcttc tttcataaga
    26881 agatagaacc atactgctct ttctcctgtt gctcctctaa ttccttctaa atattccttt
    26941 tctgtataca ttttttctga catttctttc tcctcctaaa attaaattct atattttaat
    27001 cactgtgaat tagaatattc caatgaatga ccctaccaat gctaatacaa ccaaaattac
    27061 taataactta gttattgtcc acttcttgta tttcattccc caatatacga agaatacaac
    27121 accaagtggt aataaacctg gagcaatcat atttaatgta tcttgaacaa caattgcttt
    27181 accaccaata tcaaatgata gcggagttga aagcttaact gtagttgcag ataatgctcc
    27241 catcataaac attcctagaa ttgaagcacc atcaattatc ttattgacaa taccacctga
    27301 tagaattttc ttaattgaat ctctacctaa agaatatcct aaatgaaata agtaataacc
    27361 ttcgcaaaat agtaatatac taaacattat tgggaaaaat gcacctataa cacttccttc
    27421 tgctccaaat gaagcaccta aagctaagaa tattgtttga aatgtaccaa aatctaaagt
    27481 atctccaatt ccagccaaag gtcccataag accattctta acacctgaaa taacttctcc
    27541 tgggattttt ccttcagtag ctttctcttc ttccatagct aaaactgtac cgtgaattaa
    27601 tcctccccat atagcttgag tattaaaaaa ttgtaagtgt ctctttaacg catctactaa
    27661 atcttctttt ctcttatata acttttctaa agcaggagtg aaacttgcac aaactgctaa
    27721 tgcttgcatt ctttcaaaag agttggataa ttctgctgtc caccaccatc ttagatatgt
    27781 ttttgttaca tctttctttg taagtactct tgtcttatta acttcagttg gaccttgtcc
    27841 atttttaact tctttatttt ttatttcttg cattatactt cacctaccct tttgtcttct
    27901 ttcataaagg taattaaaag agctatacaa acaccaaata ttgcagctgc agtaattgat
    27961 atttcaaaat attgaaccat aaaaaatcct ataataaaca ttggtaagaa tttattttta
    28021 cctatagtaa atattgttgt tgcaaaacct aatgcaggta atataccgcc cattactgtt
    28081 aatccattca ttaaccattg tggtataaca tctaataatg attgaactaa atctgctcca
    28141 aaaaagttac atacaaaaac tattggaaac cttaaaacaa acccaaatat taaagaataa
    28201 agtgttgcac atctccagat gccttttgta ttaccttctt cagcatactt atctgcctta
    28261 tgaaccaata cagcattacc agttcttctt aagttattaa ctaatactcc tataacacct
    28321 aaaggtaccg caatagatac tgcaacttct gcattaacac cagtttgaag tgctactggt
    28381 attgcaataa gagcagctag acatttatct gatggaatat ttccccctgc tgcgaccatt
    28441 cctagataaa ccatttctat acttgcacca acaatcatac cagttgttac atcaccccaa
    28501 agtaatccaa ggctaaaacc tataaataaa ggagacttta gtgttgagaa aagggtatac
    28561 cctgcaagac ctgctgcaaa ccaataccat aatcctgtta caattgccaa catcaaaaca
    28621 gattccattt ataattcctc ctaatttata ttttttattt aaatttcttt aacgcatttt
    28681 catatgtcat agatgattcc tctggtataa cttgtaggac tatttcaacc ccattttcat
    28741 taagttcatt aagttgttct acatcctcat ttcctaatga aacagctgta aacaccattt
    28801 tctttcctgc ttcatttgga atacctccta attgaatctt ttcatattta agtccagctt
    28861 tataagcctt atttgccata tcaacatttt taaatagaat aaatatattt ttatctccta
    28921 aagtgttgtt ttggaatgct tgtcccgcat cttctgctgt taaaataact acttctactc
    28981 ctgatggtgc tgccatttta tatatgtcag ccataaattc atcttgacct aagaagtcat
    29041 caactattat tattttttga gcttgagcga tttttaccca ttttgttata acttgcccat
    29101 gaattaatct gtggtctact cttactaatg ttatttttgc cattatattc acctcataat
    29161 ttatattttt ttaaattctt taattaaatc cacacaaagg ttattatttt ttttgacgat
    29221 tctttctggt aatgtatgta atttatcttc tttgcttaat tcttcatcta cgattaaaat
    29281 tgtctgtaag ctaagtccat ttattgcatc tattcctctt cttatagcaa cagctattgc
    29341 aacacttgat gtagatcctc catataaatc tgatattata attttcacat cttctttatc
    29401 tactacttct tcaacctctt tcataaatac agaaacatct ttttcagaac ttagtgataa
    29461 aacttcatat tgatttgaca atccaaagtt tttatttgtt tcttctacta agacttttcc
    29521 ccaagttcca tggcacagta tgattacctt atatttattc attgctaaat aaactctcct
    29581 ttatagcgat taatattttg gtttaattct acttcttctt catcaggtac catttgaatt
    29641 gatacattaa tattcttttt aataaattca tctattaaaa gaaactcttt tttattaatg
    29701 tatacatttt gagatatttt cttttttcct attcctgtag gtattcttcc aacaataagt
    29761 tttttgatat taatcccttc ttctatcatt ctatttgcag tatctaaatt tttaattaat
    29821 acaaaaacgt tatcatcagc ttgattatta taaaaatatc tccttgattc acttacagtt
    29881 aatattgata aatcaatatt ctttggtgct gccattttta tcaaaccttt agcaataaca
    29941 tcattggttg tttcatcatc tactactact atctttttta cacctagatg cttaacccat
    30001 ttatatataa cttgaccatg tattaatcta tcatcacatc tgcaatattt tactaaagac
    30061 atttttaatc aaactccttt ttctattaca ttgagctaag aactttatta atattgttta
    30121 taccagtttg tcctgcttca atacatgctt ctgctaactc ttctaaactt tttccctctc
    30181 tattaattaa agcttcaagt agcattggaa gatttactcc agtaagtgca tgaaacttgc
    30241 cacctttttt aaggtttaaa cttgcaacat tacttggcga acctcctaat aggtcagcta
    30301 atactaaaac tccgtcacct tcatctaatt catttaactt ttctacaaaa tttttattta
    30361 agtcttcaat attatcattc ctatttagtt taattgctgc tgttctttct gctggtcctg
    30421 caataagttc acagcttttt ataatttctt cactaaaact cccatgagtc ataactatta
    30481 ttcctatcac caatttcacc tcacttttct tgtcactttt tatataagca attgccgtgc
    30541 caacttatgt gtatcaataa caaatggcta ttttacagga tttaatcaaa actttttact
    30601 caattttttt taaaaactta ttatttcgat atgtatcaaa agattttttc aacctgtatc
    30661 aaatctgtat caaaaaaagt aaaaaaaaga tagccttttg gctattttta aattttgtat
    30721 caacttttga atttatctgt atcatattgt gattcaaata tatctaatat atttgcatat
    30781 tccatatctg aaataattat atcgaatgtc tcttctacta gcttaaaact ttcttttata
    30841 actaaatata attctttatt tctactaatt ctttcttcat atgatttata aactaaagac
    30901 tcttttatta ttactctttc aatcatacat gaacaatgaa atataaactt tactaaaagt
    30961 tcatcttgaa ttactaaaga atagtgttca ctaattctat taattacttc ttttaatata
    31021 aaataagcct tttccccatt taaaaaagtc aaagttttac taatattatc aattagtaat
    31081 ctatcaaaat atctaccacc attatctttt tcagcatatg taacttccat atctccataa
    31141 tgtttcttta tagattctat aatattaaaa tataatttct ctaatgtcat ttctggagtt
    31201 agagcctttc tagttgcttc tattacaata ggtgtactta ccatatctat tgcttttact
    31261 tcttttcctg tagcatcacg aataacttta gcaaatgtta aaatagaccc catatcagtt
    31321 aaaattaaaa ttccctttcc tttatcaatt ttattggcta tttctacagc ttgtactaaa
    31381 atatcctgaa ctctatcttc taatcccata ttaattgcca ctgcatggtt acaatccagt
    31441 aaagtattgg ctacattcac catgctagat gctgtagatt caccatgcat tatgactaat
    31501 attgctatac tctcctcatt taatcccaca tacgataaat aaagaaatgt tgctaaaaaa
    31561 attgcttcat cttctggaaa ctctactcca tacattaatg acatgttaga taatatttct
    31621 tttgctatgt tatattcata tgctctttcc ttcataattt catctttatt aggatgcttt
    31681 actatatttc caatctttat tctttcaatt aaattctgaa tatgtaaagc tatagctttt
    31741 attaatttat ctaatccttc tcttttgctc catttatcat gcttttgtaa aatatatttt
    31801 acagtagttg caattgaatc attaacaatg ttgttataag ctgtttgatt actactatta
    31861 tatataaaag tattcattaa attataggaa tacttctgta tgtctccatc tataacactt
    31921 ctaatttgtg actctttaat accttcttgt tgaagtttat tccaagtttc ttttatcatt
    31981 ccataaaaat ctaaatcata ttttttattt tctattaata aattttcact ttcaaaatcc
    32041 ttttcttctg gtaaaaaaat aatatcatct tttccaataa aactgaaatt ttgtacaaac
    32101 tcctcttttc tattatttcc atataatgat tctctaatat tatttggtag aagagagagc
    32161 cttacatata cacattccct tttataggtc atataatcta aaaaagctct tgcacaaatt
    32221 aattgtatat cgctttttaa ttggcctatg tttcccttac acttatataa aataaatgcc
    32281 ttaataactt cttttgaaac ctttaactta acaccaatcc taacactctc ttctttaaaa
    32341 aaataacata taagcttcat tctctcttga aagcctcttt cctctaaaga cggaatcttt
    32401 atagttacag gtattcttct taaaaacgtt tccaacattg ctgtttctgg gtcttctgta
    32461 gtggctgcaa ttatcataac tctacactcg tgtaccttat tagcctctcc taaccttcta
    32521 tatatccctt tatccataag cagaaatagc atttcttgtc cctctgcaga taatctatga
    32581 acttcatcta aaaacaatac tccattatta gcttcatgta caataccata cttatcttta
    32641 tcagctccag taaatgctcc ttttacatat ccaaaaagct gcgctaataa taattgctga
    32701 ttatcagaat aatcagcaca gttaaatatg ataaatggtg cattatcact atcttctttt
    32761 atagttaaac tatacttata catatattct gcaaatatag atttaccaac tcctgtaggt
    32821 cctattatta atgtactcaa ccccttaggt ggatatatta ctgctgcttt agcctgttct
    32881 atttgggacc ttaaacttcc atcacatcct actaaattaa aaatattgtt ctcttttttt
    32941 atactctcta aaatatactc atctttgata gaatcatttt cactatattc gtttatagag
    33001 ttaatattat caaatatccc tttatttagt ttctttccta aaatactctc aatactttct
    33061 ttatataagt actgaacagg cttacccttt atctttataa taatactttc ttttattaat
    33121 tgatttaatt ccttactagc attacttcta tttataccta cttcagtagc tatatattct
    33181 gcatcaaatc caaatctaat gccattatta aagttcaagt gttcttctgt taaccttttc
    33241 aagcaaatta aaactttttc tttccttgat agcttctttt gtgtcatagt taacctcccc
    33301 tataagcagt aatactgtta aacatttatt attaagctta attctacaat attttaatat
    33361 ttttgtctaa ttatgtaact attgattttc tttcctattc gttttataat ataaattacg
    33421 ttaccctcat cttttataga ggaggaattt atatgaattt tttatcagat ttacacaccc
    33481 actctatagt cagtggtcat ggctatagca ctttactaga aaatattaat tattgtaaag
    33541 aaaatggaat taagatacta ggtacatctg aacatggtcc taagatgcct ggttctcccc
    33601 acagatggta ctttcacaac attcaaaata tcccaagaat cataaataac attataattt
    33661 taagaggctg tgaagcaaat atactagata ttaaaggaaa catagaccta gagccttttg
    33721 taattcctcg cttagattat cttattttgt catttcacga agctgtgttt tctccaaata
    33781 cattagagaa taatactaaa gctttaataa atgcaataaa taagcatgat aatattgaaa
    33841 tattaggaca ccttggaaac ccaaactacc caatcgacta tgaattaatc attaaattag
    33901 ctatagaaaa gaatatctta atagaaataa ataattgttc tattaaaggc gtgtcaagaa
    33961 atggtagctc ggataactgt aagtatattg ctacactttg caaaaaatat ggtgctaaaa
    34021 tcatactgac ttcagatgct cacatttgtt ttgacatagg taactatgag tattctgaaa
    34081 atatcttaaa ggaaattaat tttccagatg aattaataat gaattatcct aaaaaactta
    34141 ttaatcattt tcaccaaaaa ggtaaattac tagatgttga ttatacaaat atctaagtaa
    34201 taatacatgc ttactttaac tcccataaaa attttaatac tatttatatt atatgaaata
    34261 aagaaattat aataaagaag ctatttaata aagcttaatt acttttatga acttgatgga
    34321 ttgatatggt ctatgatagc aatagaaatt ataacatttt taataaactt agttttatat
    34381 accttatagt ataaatctaa aaaagcatca tctaaaaagg agctgtcaca tgagcaaatt
    34441 aaatttgttc tatgatagct ctttttttac ttattttaat taggtatatt tttaattatt
    34501 ttatataaag cttatgttct aagtaaaatt atgcataaca aacaaaggta taaaaatacc
    34561 attttttcag ataatattta attataaata ataaatttag a
//
LOCUS       DAEPID010000040        33951 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.040, whole genome shotgun sequence.
ACCESSION   DAEPID010000040 DAEPID010000000
VERSION     DAEPID010000040.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 33951)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 33951)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..33951
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.040"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            complement(68..1255)
                     /locus_tag="KR257_002135"
     CDS             complement(68..1255)
                     /locus_tag="KR257_002135"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892577.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="HBH0030821.1"
                     /translation="MNITKNFLKDYLEKFGETPFLVRLKDEEEFLIGEGSPQFKVIVN
                     NDISKSELLKSTSLALGEAYINRDIEVEGDLFLTLNLLLKQIDKFNIDNSAVKHLLHS
                     SNSMRHQKKEIHAHYDIGNDFYSLWLDKTLSYSCAYFRNDNDTLYDAQVNKVHHILTK
                     LNLEEGMSLLDIGCGWGFLLIEAAKKYKIHGVGITLSEEQFKEFNARIKEENLQDYLE
                     VRLMDYRELKKSDLMFDRVVSVGMLEHVGRENYELFIKNVNAVLKDGGLFLLHYISGL
                     QESYGDPWIKKYIFPGGVIPSLREMIHICSDYKYHTIDVESLRLHYVKTLLYWQKNFS
                     ENLPKIKEMFDDKFIRMWDLYLCSCAAAFNTGIIDIHQILFTKGIKNDLPLTREYMYN
                     CSK"
     gene            1528..2352
                     /locus_tag="KR257_002136"
     CDS             1528..2352
                     /locus_tag="KR257_002136"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729220.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATPase"
                     /protein_id="HBH0030822.1"
                     /translation="MEVYALVGSSGTGKSFKALEFAYENDIEYIIDDGILIYKNKVLA
                     GISAKQANTTIEAVKRAIFYNLEHRQEVREAIKKENIRKILIIGTSKKMVNQIVERLS
                     IGRVCKFINIQDISTKYEIEIAKQARKEGNHVIPVPAVEIKSMASGLSINSLKRLFRK
                     GNNRNMVVLEKTIIRPTFSYIGKFYISADVIKQIIEYEVYNFGSIDRINKINIENCNN
                     FMNIFVSININDLETIKKIEDIQQTIKKSIEKMTLVNVQKIDINIHKIKKINFLQC"
     gene            2481..3746
                     /gene="gluD"
                     /locus_tag="KR257_002137"
     CDS             2481..3746
                     /gene="gluD"
                     /locus_tag="KR257_002137"
                     /EC_number="1.4.1.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420866.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NAD-specific glutamate dehydrogenase"
                     /protein_id="HBH0030823.1"
                     /translation="MSGKDVNVFEMAQSQVKNACDKLGMEPAVYELLKEPMRVIEVSI
                     PVKMDDGSIKTFKGFRSQHNDAVGPTKGGIRFHQNVSRDEVKALSIWMTFKCSVTGIP
                     YGGGKGGIIVDPSTLSQGELERLSRGYIDGIYKLIGEKVDVPAPDVNTNGQIMSWMVD
                     EYNKLTGQSSIGVITGKPVEFGGSLGRTAATGFGVAVTAREAAAKLGIDMKKAKIAVQ
                     GIGNVGSYTVLNCEKLGGTVVAMAEWCKSEGSYAIYNENGLDGQAMLDYMKEHGNLLN
                     FPGAKRISLEEFWASDVDIVIPAALENSITKEVAESIKAKLVCEAANGPTTPEADEVF
                     AERGIVLTPDILTNAGGVTVSYFEWVQNLYGYYWSEEEVEQKEEIAMVKAFESIWKIK
                     EEYNVTMREAAYMHSIKKVAEAMKLRGWY"
     gene            3959..4549
                     /locus_tag="KR257_002138"
     CDS             3959..4549
                     /locus_tag="KR257_002138"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729221.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptidase M56"
                     /protein_id="HBH0030824.1"
                     /translation="MHFKSKDLNLKYLVLFLKIVYWFNPFICIMEKYMDLDCELYCDE
                     RVLKNCTVQQKQEYALTIVNSMKRSTNFSNKFVAGLNKQSDIRKRVINMFSEKHKNGI
                     LRALIISLFSSITFFKFDSTSIIEENDFLERSRYTFEGRQEDMFVTIDFIYADVPIKL
                     RKEHEENCRVNGIVPKDSDSIEIIPRFYKDCMDLKK"
     gene            4879..6012
                     /locus_tag="KR257_002139"
     CDS             4879..6012
                     /locus_tag="KR257_002139"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888023.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptidase M56"
                     /protein_id="HBH0030825.1"
                     /translation="MSNFILNGIFRTVIVSSLSILLILIFKKNVFKRFSKKFNYYIWM
                     IVVIKLFLPFTYYTFTINILRSKKHININNINLEGFNNVSTISNNIILYTWIITVVVY
                     LIYTIFKYIKLKNLINDLSYDVDDREIVNLYKNILEEFNITKDIKLKYSYEVETPAFF
                     NSCVLLPPHEYKLKELDWIFRHELMHFKSRDLYLKYVILFLKTVYWFNPFIYIMDKHI
                     DLDCELYCDERVLKNRNSEEKKDYALTILNAMRKGSNTSNKFIAGLHKQSDIKKRVMN
                     MFNEKYKNGILMALTLCLLSSITFLKVNSTSIVNLNVLPKGFEDLRTVSSIRFSVIGF
                     TYADAPKNMREEYKINCESLGLIPKDSDKIEVGIEYYDSLLND"
     gene            6928..7950
                     /locus_tag="KR257_002140"
     CDS             6928..7950
                     /locus_tag="KR257_002140"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729223.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="C40 family peptidase"
                     /protein_id="HBH0030826.1"
                     /translation="MKKKILIPVFASVMALSVSSIVNADEVNDSSQNKDDKTNTELNL
                     GEYKEVKYKVAKIKDGVAIKIREEGQVQNIAYSGDEFTVLGTQGEWVKVKVEDGEGWL
                     ATRYVDISEGVGYTNADKVNLRKDKSESSEVIEELEKGSSLLVLEDNGDWLKVKDGET
                     EGYVKSSYISDKAPVIEEPQVNPSIDQNVDSTNNNQQNNANTNQQNNNSNVPTANSNA
                     VQAVLNLAYSKQGCPYVWGAEGPNTFDCSGFTQYVYRNAVGKNIPRTSKAQSKYGQTV
                     SKANLQPGDLVFFTTNGSGSVSHVGIYVGGGNMIHSPSTGKTVSVTSINSSYYTARFV
                     TAKRIL"
     gene            8247..9167
                     /gene="pyrB"
                     /locus_tag="KR257_002141"
     CDS             8247..9167
                     /gene="pyrB"
                     /locus_tag="KR257_002141"
                     /EC_number="2.1.3.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434504.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aspartate carbamoyltransferase"
                     /protein_id="HBH0030827.1"
                     /translation="MLKSRNLIQPEDFSIEEIDEILELAQKIIDNPSKYSRICEGKLL
                     ATLFYEPSTRTRLSFESAMNRLGGRVVGFSEPNSSSASKGETLGDTMRIVSGYVDIIA
                     MRHPQSGAASEAARYTEVPFINAGDGKNQHPTQTLTDLLTIKSLKGTLESHTIGLCGD
                     LKYGRTVHSLVKAMARYKNTKFVFIAPEELKMPDYIKEAIKGHAYYETNNLDDVIGSL
                     DVLYMTRVQQERFEDKSEYERLKNYYILNKAKLEKASKDMLVMHPLPRVNEIDIDVDS
                     DDRAVYFKQAKYGMYVRMALIIKLLGINED"
     gene            9206..9898
                     /locus_tag="KR257_002142"
     CDS             9206..9898
                     /locus_tag="KR257_002142"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420878.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dihydroorotate dehydrogenase electron transfer
                     subunit"
                     /protein_id="HBH0030828.1"
                     /translation="MYKILENIYIGEDMYRMKVKGNFEGKMGQFYMLRAWDTYPVLSR
                     PISIHDIDEEGITFLYKVVGEGTQILSNLKVNDTIKLEGPYGNGYAKVDGKVALVGGG
                     IGVAPLYLVAKNIKNCDAYLGFREDVILEDEYKQVCNKVYTTVGNTFVTDIIDVEKYD
                     YILTCGPTPMMEKLVKMVEGTKTRIMVSLENHMACGVGACLVCTCKTNGGNKKTCKDG
                     PVFWGEDVIFNG"
     gene            9891..10793
                     /locus_tag="KR257_002143"
     CDS             9891..10793
                     /locus_tag="KR257_002143"
                     /EC_number="1.3.1.14"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860662.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dihydroorotate dehydrogenase"
                     /protein_id="HBH0030829.1"
                     /translation="MGNLSVKFGSVEFKNPVIMASGTFGFGKEYNEIYDIQKLGGISS
                     KGLTLNKKPGNNGMRVHETPSGMMNSVGLENPGVQGFIDYELPFFSKLDLVRIANVGG
                     GTLEDYLLGVQMLNDKPIDIIELNISCPNVKAGGMAFGIKNEVAREVVREVRNITKLP
                     LVIKLSPNAEDIVGMAKVCEEEGADGVSLVNTFKAMAIDIKNRRPVFENVYAGLSGPA
                     IKPIALRMVHEVCKNVNIPVMGMGGITKATDAIEFIMAGATCIQVGTANFMNPRIGIE
                     IIDGINEFMDREGIKSLDEIRGII"
     gene            10878..11462
                     /locus_tag="KR257_002144"
     CDS             10878..11462
                     /locus_tag="KR257_002144"
                     /EC_number="2.4.2.10"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420885.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="orotate phosphoribosyltransferase"
                     /protein_id="HBH0030830.1"
                     /translation="MSKVDVVDILKKSDALLEGHFLLSSGKHSNRYVQCAKVLRFPEY
                     AAEVLSTVVEQIKDLDIDLVVGPAMGGVIVSYELGRQLGKEAVFTERKDNTMELRRGF
                     EVKKGAKIIIAEDVVTTGKSTMETKRVLEALGGEVVGVACIADRTNHDIGMPIYSAIK
                     LDIQVYESDECPLCKEGKLPVVKPGSREFKELGM"
     gene            11677..12603
                     /locus_tag="KR257_002145"
     CDS             11677..12603
                     /locus_tag="KR257_002145"
                     /EC_number="1.1.1.169"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729225.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="2-dehydropantoate 2-reductase"
                     /protein_id="HBH0030831.1"
                     /translation="MKNQLNENHKKVVFFGVGAVGATFAEQFFNSKYDFKILCDNERK
                     KRYLEEGFIINGKRYDFDYVTKDEYKQEADFIIIGLKYNNLKENIKELDGLVGKNTVI
                     MSLLNGVDSEEIIGERFGIEKMVYSYVTNIDAKKINNNIIHTTNGIIVFGNKDNSEDR
                     KTNIITEVFDDVNIEYTLSKDIQRDMWWKYMVNIGVNQTSAILGAPYGVFQSSEHLRE
                     LAKSAMREVVAIAQAKDISLTEDDVEHSLHRILEHSKEGRTSMLQDVEAHRLTEVDMF
                     SKNICKLGKKYNIPTPINQTFFYMIKVIESRF"
     gene            complement(12655..13545)
                     /locus_tag="KR257_002146"
     CDS             complement(12655..13545)
                     /locus_tag="KR257_002146"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435002.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LysR family transcriptional regulator"
                     /protein_id="HBH0030832.1"
                     /translation="MFEELKTFVAVVEYKNFTKAGEYLNLSQPSVSKHIKNLENYFKV
                     VLINRSIKQKTIFITESGQILYKRAKEILNLLNITYHDVSQVSDAITGHLKIGASLTI
                     GEYILPNFLALFSKKYPDIDVEVFIKNTSIVSSHVKDYILDIGLIEGTCSSPSFIQEY
                     FFEDKMVLALPYKSHLLKDFSFDKLQNQKWIVREDGSGTRDYLDMFLSVKEIIPKSMM
                     VFGSNYAVKESVRNNLGITIVSNLVTSLPVLNNELSVIELGSSYNRHFSYIFPKDITL
                     SKAATIFIEELKIFSNLNSI"
     gene            13733..14764
                     /locus_tag="KR257_002147"
     CDS             13733..14764
                     /locus_tag="KR257_002147"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420895.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="putative sulfate exporter family transporter"
                     /protein_id="HBH0030833.1"
                     /translation="MLKKKSSLTLKTIREILPGLFVSVLVGYISIFISILIPKVGAAS
                     ISIFLGMFVGNLFLNQKVFQKGYKFSETDLLSYSIVLLGATLSVSTLIDLKVSGILFI
                     ILQMTITIIAALYIGKKLGFEENFRFLMASGNAVCGSSAIGATVPVVNATDKEKGIAV
                     TIVNVTGIFLMFLLPIISQFLYSHELVKTSAMIGGTLQSIGQVVASGAIVGENVKDLA
                     TIFKIVRVIFLVVVVLVFGHMKNQSNREILEEEKDEIKKKKVTIPWYVIGFFITCALF
                     SMNIIPQEVSVLCKEISNKLEIIALAAIGLKVNVKDLVKQGKEVSLYGLFVGIVQVVS
                     AVVLIKIFI"
     gene            15058..15933
                     /locus_tag="KR257_002148"
     CDS             15058..15933
                     /locus_tag="KR257_002148"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895282.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA glycosylase"
                     /protein_id="HBH0030834.1"
                     /translation="MNVYEKGNGVILEGVTDFDPVHIFECGQCFRWHKQEDGSYTGVA
                     KGRILNVKKENDKIYLNNTNLKEFNSIWYNYFDLGTDYTEIKNKLKNMDEYLNKATEF
                     GWGIRILRQDGWEMLISFIISSNNRIPMIQRAIENLSRKFGKYIGEYEGNEYYAFPTP
                     EELNKASQEEIRACQTGFRDKYIKSTTQAVIENNDEVSEYTNLSTEDCRKELLKFNGV
                     GPKVCDCIALFGMQKYDSFPVDVWVKRVMQEFYIDEDMSLPKMRTYGIDKFKEMSGFA
                     QQYLFYYARELGIGK"
     gene            15951..17441
                     /gene="cls"
                     /locus_tag="KR257_002149"
     CDS             15951..17441
                     /gene="cls"
                     /locus_tag="KR257_002149"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420900.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cardiolipin synthase"
                     /protein_id="HBH0030835.1"
                     /translation="MGVIGTIFLFYLIISYLAGAIISVIILLENRDPAKTMSWLLMFI
                     IFPGVGLMIYAISGRNIRKRKLFKTQKLANNIKEKKLFDTLEKITEIVELEKESIKQN
                     KLLRDEEDGSYRKRVINMLLKTGMFPFTKNNKVDVFVDGNEKFKRLIEDIREAKDHIH
                     LEYFIIKDSEIGRVLKEELIKKAKEGIKIRILYDDVGCWRFWFNRKFFREMREVGIEI
                     AAFLPTKFPIIGGKLNYRNHRKIVVIDGIIGYTGGINIGDEYLGKNDKFGYWRDTHIR
                     IKGISVYMLQMTFLIDWYYTTKEVLVTKNYFPSVGNVGESMIQVVASGPDSDWEDIHY
                     AYFSAICQARKNVYIETPYFIPDESLLKAIKSAALSGVDVRIIFPKIADHKIVNIASY
                     SYFEEILRAGGKVYLYNKGFIHSKVVIIDDKIASAGTANMDLRSFMLNFEVNAFIYDE
                     EVIRVMTDDFFEDLSHCEELNLEVFKNRNIIQKIKESVARLFSPIL"
     gene            17634..17918
                     /locus_tag="KR257_002150"
     CDS             17634..17918
                     /locus_tag="KR257_002150"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012062101.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="co-chaperone GroES"
                     /protein_id="HBH0030836.1"
                     /translation="MKIRPLADRVVIKKVEAEEKTASGIVLPGAAKEQPQIAEVVEVG
                     PGGIVEGKEIKMELTVGDKVIFQKYSGTEVKIEGQEYTILRQSDVLAVIE"
     gene            17951..19579
                     /gene="groL"
                     /locus_tag="KR257_002151"
     CDS             17951..19579
                     /gene="groL"
                     /locus_tag="KR257_002151"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729227.1"
                     /note="60 kDa chaperone family; promotes refolding of
                     misfolded polypeptides especially under stressful
                     conditions; forms two stacked rings of heptamers to form a
                     barrel-shaped 14mer; ends can be capped by GroES;
                     misfolded proteins enter the barrel where they are
                     refolded when GroES binds; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="chaperonin GroEL"
                     /protein_id="HBH0030837.1"
                     /translation="MAKEIKFSEETRRALEAGVNKLADTVKVTLGPKGRNVILDKKFG
                     SPLITNDGVTIAKEIELEDRFENMGAQLVKEVATKTNDVAGDGTTTATVLAQAIIREG
                     LKNVTAGANPILLRKGIQKAVTVAVEELKNQSRIVETQEAISQVASISAGDEEVGKLI
                     AEAMEIVGKDGVITVEESQTMNTELDAVEGMQFDRGFVSAYMVTDVDKMEAVLNDPYI
                     LITDKKISNIQELLPVLEQIVQQGKKLLIIAEDVEGEALSTLVVNKLRGTFDVVAVKA
                     PGFGDRRKEMLQDIAILTGAQVISEELGYDLKEADLSMLGRASSVKVTKESTTIVDGS
                     GDKKAIEDRVTQIKHQVEQTTSDFDREKLMERLAKLAGGVAVVKVGAATEVELKERKL
                     RIEDALNATRAAVEEGIVAGGGTAFVSVIPAIGTLIESLEGEVKLGAQIVKKALEEPL
                     RQIAINAGLEGAVIVQNVVNSEAETGFDALNEKYVNMIEAGIVDPTKVSRSALQNAAS
                     IASTFLTTEAAVADLPEKEDVGMPGMGGGMPGMM"
     gene            19841..20581
                     /gene="larB"
                     /locus_tag="KR257_002152"
     CDS             19841..20581
                     /gene="larB"
                     /locus_tag="KR257_002152"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425348.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nickel pincer cofactor biosynthesis protein
                     LarB"
                     /protein_id="HBH0030838.1"
                     /translation="MDLRKLLEEVKNENIDIDFALEKLKDLPYEDLGYANIDHHRELR
                     NGYPEVIYCEGKSDEHILGIIDKMNQKSSNILGTRCRKETFLKIKEIYNHAEYEEASK
                     ILKIQNHDIENIGKGKIVIATGGTSDIPVADEAYHTAKFLGNDVDRIYDVGVAGIHRL
                     LNKRHKIDSARVIVAVAGMEGALASVIGGLVDVPVIAVPTSVGYGANFGGLAALLAML
                     NSCASGISVVNIDNGFGAGYLASMINKL"
     gene            20665..21399
                     /gene="larC"
                     /locus_tag="KR257_002153"
     CDS             20665..21399
                     /gene="larC"
                     /locus_tag="KR257_002153"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895287.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nickel pincer cofactor biosynthesis protein
                     LarC"
                     /protein_id="HBH0030839.1"
                     /translation="MSEKILYFDIISGISGDMTLASLLNLGVPKEIFLEEIHKLRMSD
                     EFNINISSKTENGIVGTKVEVITKEKHTHRNLVDIFEVIDKSTLNENVKSKAKKIFMV
                     IGEAEAKVHGTTIDKIHFHEVGAIDSIVDIVGASILVDLLCVDKVCASTVSVGSGFVK
                     CEHGIIPIPAPATIEILKGVPIKLNNVNGECTTPTGAAIIKVLCDEFVDELEFSPKQI
                     GYGIGHKKFEVPNILRTVLGEKKKKN"
     gene            21429..21848
                     /locus_tag="KR257_002154"
     CDS             21429..21848
                     /locus_tag="KR257_002154"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425343.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF111 family protein"
                     /protein_id="HBH0030840.1"
                     /translation="MSSEIYSYLYEKILDEKALDIYTESIYMKKNRPATKVSILCNES
                     DLEKFIKILLLETSTFGVRYNAYNREILERKFVKLDTKYGVVTVKLGYYKGKLVKATP
                     EYNECKTIAKNEDIPIKKVFADINFRIKEEFSENLLT"
     regulatory      21908..22009
                     /regulatory_class="riboswitch"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00167"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="purine riboswitch; Derived by automated
                     computational analysis using gene prediction method:
                     cmsearch."
                     /bound_moiety="guanine and/or adenine"
                     /db_xref="RFAM:RF00167"
     gene            22230..23765
                     /gene="guaA"
                     /locus_tag="KR257_002155"
     CDS             22230..23765
                     /gene="guaA"
                     /locus_tag="KR257_002155"
                     /EC_number="6.3.5.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000743900.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glutamine-hydrolyzing GMP synthase"
                     /protein_id="HBH0030841.1"
                     /translation="MKHELVLVIDFGGQYNQLIARRVRENNVYCEILPCTASIERIKE
                     KNPKGIIFTGGPNSAYLEDSPTISKEIFELGVPILGICYGIQIMSHVLGGVVRKGNKQ
                     EKEYGKTAITYGKSSLFEGITTNSVWMSHTDLIEKVPEGFTIVANTNDCPVAAMENVE
                     RNLYGVQFHPEVEHCLEGDKILTNFLYNICKVKGDWTTDSFIEDKIKELKEKIGDKKA
                     LCALSGGVDSSVAAVLIHKAIGDNLTCIFVDHGLLRKNEGNDVERIFREKFDINLIRV
                     NAEDRFLSKLKGVSEPEAKRKIIGEEFIRVFEEESNKLGKMDFLVQGTIYPDVIESGH
                     GNAATIKSHHNVGGIPEDVDFQEIVEPLRELFKDEVRKIGLELGIEEGLIFRHPFPGP
                     GLGIRVIGDVTKEKCDILREADAVYMDELRKAGLYREIWQAFATLPDVKTVGVMGDER
                     TYAYLVGLRAVTSSDGMTSDWYKMPYDVLERISNRIINEVDGVNRVVYDITSKPPGTI
                     EWE"
     gene            complement(23842..24888)
                     /locus_tag="KR257_002156"
     CDS             complement(23842..24888)
                     /locus_tag="KR257_002156"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003460085.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="site-specific integrase"
                     /protein_id="HBH0030842.1"
                     /translation="MPAYKDEQRKSWYASFYFTDFDGDRKKKIKRGFKTKKEALEFER
                     EFLNKSKMSTDMSFESLIEEYMHDMSSRLKLSTLETKKYLINFRILPFFKSLKINEIT
                     ATHIRRWQNELLKSDYSQTYIKTINNQLVAVLNYAVKYYNLPSNPAHLAGSIGKKNAD
                     EMNFWTLEEFKKFIEFEKKSEPRLAFEILFWTGLRLGELLALTPKDIFENKISVEKSY
                     IRLNGEDIVSSPKTPKSKRVVPIPHFLYNNIKDYLSKLYDLKDNERIFKFAKSYLSKE
                     LDRCCKLSNVKRIRVHDLRHSHASLLVNMDVNILTIAERLGHEKVETTWNTYSHLYPN
                     KQLEVAQKLDNLNI"
     gene            complement(24965..25180)
                     /locus_tag="KR257_002157"
     CDS             complement(24965..25180)
                     /locus_tag="KR257_002157"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009901700.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="HBH0030843.1"
                     /translation="MLKKLRKKKRMTQLELAEKMRRNRSYISKLENQEYKDIGISTIL
                     DLSIALEEDFLELCKYYKLQEIKRRGK"
     gene            complement(25614..26015)
                     /locus_tag="KR257_002158"
     CDS             complement(25614..26015)
                     /locus_tag="KR257_002158"
                     /inference="COORDINATES: protein motif:HMM:NF013540.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HBH0030844.1"
                     /translation="MQTLAEIIKEYRSEHNLSLREFSNLCGVSHTYIDKIEKNRDPRN
                     GKAVEPTLDMLEKMSFGLNLTLKELLTKLGKIQPNTQQDDELLKKVNSKEDNEVNELI
                     NRLASLDSDDKNAIKKMIDNAYYKAVNTKKE"
     gene            26180..26392
                     /locus_tag="KR257_002159"
     CDS             26180..26392
                     /locus_tag="KR257_002159"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019161272.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HBH0030845.1"
                     /translation="MKNNLQYIRKESRISQKKFADKIGISRPYLSRIENGKVNPSLEI
                     AHKISLETGKTINEIFFDFTVNHSKL"
     gene            26632..26769
                     /locus_tag="KR257_002160"
     CDS             26632..26769
                     /locus_tag="KR257_002160"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0030846.1"
                     /translation="MQREQTTLRIPEDLHKALIDLSSDIGMPITSIIIIACWLYISKI
                     N"
     gene            complement(26755..27066)
                     /locus_tag="KR257_002161"
     CDS             complement(26755..27066)
                     /locus_tag="KR257_002161"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0030847.1"
                     /translation="MTTITVRIYTPLNENLEKISYQTGILKSSLILYAINDIIRNSKV
                     NELQSISYKSDDTVRSTLRIPGVLKELLEKTAKENNLSINSLINNVVHSFCISDWLIY
                     L"
     gene            27187..27357
                     /locus_tag="KR257_002162"
     CDS             27187..27357
                     /locus_tag="KR257_002162"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0030848.1"
                     /translation="MEKVRMTVRLVPKLNQYVQNIAKECGKSKNSIIVDACWEFIEKI
                     KKENKFNVESEE"
     gene            27360..27998
                     /locus_tag="KR257_002163"
     CDS             27360..27998
                     /locus_tag="KR257_002163"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015984876.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0030849.1"
                     /translation="MNNLQIFEKLEFGQIRMAEIDNKPYFVGKDVAKSLGYKNTNDAI
                     LRHCKGVVKHEGFKINGIKIALITEGDVYRLIVGSNLPNAEKFESWVFDEVLPSIRET
                     GQYQAQQHVITELTGTIGDLKGTIKEYKKLCKITCSKKQQYSKYIKNRLDIDKANKEY
                     NQVKARLFLILGVEKWEDIDFDTSNNLIQIIDDCIRVIKSERPYKQLSYFEN"
     gene            28057..28227
                     /locus_tag="KR257_002164"
     CDS             28057..28227
                     /locus_tag="KR257_002164"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0030850.1"
                     /translation="MKNNISDSRVKYFCKCPYCGFDNEVEVKKGLKPKICCICTKEVE
                     YEKLEQQSTPAK"
     gene            complement(28230..28463)
                     /locus_tag="KR257_002165"
     CDS             complement(28230..28463)
                     /locus_tag="KR257_002165"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0030851.1"
                     /translation="MNIGKITKIEATCFDCGTKVTITESKFREVCDNGLPCPMCKEHI
                     SNSNFIAEQALQYNHAVNKLEKELDSCKNIHIY"
     gene            28532..28729
                     /locus_tag="KR257_002166"
     CDS             28532..28729
                     /locus_tag="KR257_002166"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015984879.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HBH0030852.1"
                     /translation="MAINDNINKILRDRNLKAWKLAKEIGVDSGNLYAILRGENKNPT
                     IDTLIKLADYLDVTLDELVGR"
     gene            28768..28977
                     /locus_tag="KR257_002167"
     CDS             28768..28977
                     /locus_tag="KR257_002167"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016056359.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0030853.1"
                     /translation="MAKAVAKEQLFYRAKDIAKILDVCEATAYKIIGELNKELEKEGF
                     KTFSGRVSVAYFKERYCYKPRKGVI"
     gene            29135..29347
                     /locus_tag="KR257_002168"
     CDS             29135..29347
                     /locus_tag="KR257_002168"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009894686.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0030854.1"
                     /translation="MVFNLEKFKVGNAIRISCERFGFEIDCIVVVATEKELNLAYFDE
                     GRGCMEYQALITEDIQDGDYEIKILS"
     gene            29446..29688
                     /locus_tag="KR257_002169"
     CDS             29446..29688
                     /locus_tag="KR257_002169"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860995.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0030855.1"
                     /translation="MEAARLIAMGQIKQAEKEISKLQGTKNNSSLMWWEAVKFASQNI
                     LQGLEHDIELEASTDFREFMITQEELERDRPIDVQI"
     gene            29772..30281
                     /locus_tag="KR257_002170"
     CDS             29772..30281
                     /locus_tag="KR257_002170"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861752.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="siphovirus Gp157 family protein"
                     /protein_id="HBH0030856.1"
                     /translation="MSTLYELTTDLLEIEEGLTETTGNEAEKLEEIKEIIKQEIQNKN
                     TRIVSVILNIDSDINSIDSEIKRLQELKRVKKNTLDRLKSNIKDCMELLGTKKVETVL
                     GNISIRKSAGSLVIEDEEKIPAIYKTVEQVVKVDKNTIKDFIKKGHEVEGCRIEYGTT
                     LTIPKAKKE"
     gene            30291..30905
                     /locus_tag="KR257_002171"
     CDS             30291..30905
                     /locus_tag="KR257_002171"
                     /inference="COORDINATES: protein motif:HMM:NF016302.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ERF family protein"
                     /protein_id="HBH0030857.1"
                     /translation="MEINNIYIKLMDVRVKFSKLNLKKSGENKFANFKYFELADFLPQ
                     ATGLLEEAKLCPIVTFTNEYATLTLINGENPSEQIVFTSPMRDLQLKGSNELQALGGI
                     ETYQTRYLYIQLLNITENDSFDAVSGKEESKSNSNNNVKQSNRILTDKQLTRLYAIAN
                     SVGVNKALLKEQVFKQLGKDIKDLNKSEYDAVCAAYEKQAFKGA"
     gene            31682..31780
                     /locus_tag="KR257_002172"
                     /pseudo
     CDS             31682..31780
                     /locus_tag="KR257_002172"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420554.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="replication protein"
     gene            31850..32101
                     /locus_tag="KR257_002173"
     CDS             31850..32101
                     /locus_tag="KR257_002173"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009901719.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0030858.1"
                     /translation="MIIIRSQDRLDLMRVNRVEIGFNQVYAILENDIRKIGEYESIER
                     AMQVLNDIQKFIENGVRTDYIDSCRVRHNQEKVFEMPFE"
     gene            32119..32475
                     /locus_tag="KR257_002174"
     CDS             32119..32475
                     /locus_tag="KR257_002174"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016056367.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0030859.1"
                     /translation="MAKVWVDAGTFLERTKDIEDMFEFNLRKVRDRNKKINVIDLRVN
                     NEGQGRKGKKVECFNIVTGETKVFNTAVEASKYVYFTDVYIAHLARTGKVSKNGWKAR
                     YIQEVTDGIGKCGTSN"
     gene            32444..32593
                     /locus_tag="KR257_002175"
     CDS             32444..32593
                     /locus_tag="KR257_002175"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018112755.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0030860.1"
                     /translation="MVLANVEQVIKLAEKILNKKKCSVNKAIDIVIKILSKYECEGML
                     RNEFN"
     gene            32580..33029
                     /locus_tag="KR257_002176"
     CDS             32580..33029
                     /locus_tag="KR257_002176"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0030861.1"
                     /translation="MSLIKYRGYDFENEKWIYSATIMWSNILECLVMLTEGCKWQKVS
                     NVGVCSGEWARNNQEICEGDILKGYDNFHDTSQYGVVKRDIGSIKLYLEWHYLKKLEG
                     EWIELINKTEIYHSRDYKIVGNEYENLEEVRTEFLERKESLENEYLS"
     gene            33132..33308
                     /locus_tag="KR257_002177"
     CDS             33132..33308
                     /locus_tag="KR257_002177"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009894708.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0030862.1"
                     /translation="MDDRLEMINASVNYIQMICESSNIAIIAERGRVRILDLETKEKY
                     DLLKNKLEEMLEEI"
     gene            33418..>33951
                     /gene="dcm"
                     /locus_tag="KR257_002178"
     CDS             33418..>33951
                     /gene="dcm"
                     /locus_tag="KR257_002178"
                     /EC_number="2.1.1.37"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861009.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA (cytosine-5-)-methyltransferase"
                     /protein_id="HBH0030863.1"
                     /translation="MLTFLDLFAGIGGFRLGMEKAGHKCLGHCEYDKFANLSYNAMHK
                     PKEDEWFERDIREIRTENIPRADVWCFGFPCQDISVAGKQFGFRGERSSLFFTVTKLI
                     RELKEEDRPKYLLIENVKNLLSVNGGFDFLKVLVELDEIGYDAEWQVLNSKNFGVPQN
                     RERIFIVGHFRGRSTRKV"
BASE COUNT        13447 a         3542 c         6102 g        10860 t
ORIGIN      
        1 caaatcttat ttagaaatag ctctattttt tgtaattaaa tttaaattat attcaatttg
       61 taaaatatta ttttgaacaa ttatacatat actctctagt tagaggtaaa tcatttttta
      121 tacctttagt gaaaagtatt tgatgtatat ctataatacc agtgttgaaa gcagcagcac
      181 aagaacaaag gtataaatcc cacattctta taaacttatc atcaaacatt tctttaatct
      241 ttggaagatt ctcagagaaa tttttttgcc agtatagtaa ggtttttaca taatgtaatc
      301 ttaaactttc tacgtctata gtatgatatt tgtaatcact acaaatatgt atcatttctc
      361 ttaggctagg aataactcct cctgggaaaa tatatttttt tatccaaggg tctccataag
      421 attcctgcaa tccacttata tagtgaagta aaaacaatcc accatctttt aaaacagcat
      481 ttacgttttt aatgaaaagt tcatagtttt ctctaccaac atgttcaagc atcccaacgc
      541 ttacaactct atcaaacata aggtctgatt tttttaattc tctatagtcc ataagtctta
      601 cctcaagata gtcttgaagg ttctcttctt taattcttgc gttaaattcc ttaaattgct
      661 cttcgctaag tgtaattcca acgccgtgaa ttttatattt ttttgcagct tctattagta
      721 aaaatcccca accacaacca atatcgagaa ggctcatacc ttcctctaaa tttagtttag
      781 ttaatatgtg gtgaacttta ttgacttgag catcataaag agtatcatta tcatttctaa
      841 agtatgcaca agaataacta agtgtcttat ctaaccataa gctataaaaa tcgttgccaa
      901 tgtcatagtg ggcatgtatt tctttctttt gatgtctcat tgaatttgat gagtgcaata
      961 gatgttttac agctgaatta tcaatattga atttgtctat ttgttttaaa agtagattta
     1021 aagttaagaa taaatctccc tcaacttcaa tgtctctatt tatgtaggct tctccaagtg
     1081 ctaaagatgt actttttaat agttcagact tgctaatatc attatttact ataactttga
     1141 actgagggga gccctctcca attagaaatt cttcctcatc tttaagccta actagaaatg
     1201 gtgtttcacc aaatttctct aaatagtctt ttaaaaaatt ttttgtaata ttcatattac
     1261 cagctccttc taatgtaaat ccagtaagtt tccctgctta aaatatatta tagtcctttt
     1321 tttaaaaaag taaaattttt tcaataaatt ttttatttaa aggaaattta ttttttgtaa
     1381 agaaatttca tgttgtagta tattttttgc ttataaattt tggtactgga tataatatta
     1441 aactgttaat gatataataa atttaatcta taaagtaaat aaaattttgt aataaatagt
     1501 taaagctatt ttataaggag atatatgatg gaagtatatg ctttggttgg gtcaagtggc
     1561 acagggaaga gctttaaggc tttagagttc gcatatgaaa atgatataga atatataatt
     1621 gatgatggga ttttaatata caaaaacaag gttttagctg ggatatcggc aaaacaagca
     1681 aatactacta tagaagcagt taaaagggct attttttata atctggagca tagacaagaa
     1741 gttagagaag caattaaaaa agaaaatata agaaaaattc ttattattgg gacatcaaaa
     1801 aaaatggtta atcaaattgt agagagattg tcaattggaa gggtttgcaa gtttataaat
     1861 atacaagata taagtactaa atatgaaata gaaatagcaa aacaagctag aaaagaagga
     1921 aatcatgtaa ttcctgttcc agcagttgag ataaaaagta tggcaagtgg tcttagtata
     1981 aattctttga agagactttt tagaaaagga aataatagga atatggtagt tttagaaaaa
     2041 acaattataa gaccaacttt tagttatata ggaaagtttt atattagtgc tgatgtaatt
     2101 aaacagatta ttgaatatga agtatacaac tttggaagca ttgatagaat aaataaaatc
     2161 aatatagaga attgcaataa ttttatgaat atttttgtaa gtataaatat caatgattta
     2221 gaaactataa aaaaaattga agacatacaa cagacaataa aaaagtctat tgagaaaatg
     2281 actttagtta atgtacaaaa aatagatatt aacattcata aaattaaaaa aataaacttc
     2341 ctccaatgtt aaaaaataaa ctgagaaaat gatatactaa tttgcaataa agtgtgctat
     2401 aattaaactg taaatttagg aaatggtttt ttctaaatgg agtatacata attataacgt
     2461 atttataagg gggctttcaa atgtcaggaa aagatgtaaa tgtcttcgag atggcgcaat
     2521 ctcaagtaaa aaatgcatgt gataaattag gtatggaacc agcagtttat gaattattaa
     2581 aagaacctat gagagttata gaggtttcaa ttccagtaaa aatggatgat ggttctataa
     2641 aaacttttaa aggatttaga tcacaacata atgatgcagt agggccaaca aaaggtggaa
     2701 taagattcca tcaaaatgtt tcaagagacg aagtaaaagc tttatctata tggatgactt
     2761 tcaagtgttc tgtaacaggt ataccatatg gtggaggtaa aggtggaata atagtagatc
     2821 catcaacttt atctcaaggt gaattagaaa gattaagtag aggatacata gatggaatat
     2881 ataaattaat aggtgagaaa gttgacgttc ctgcaccaga cgtaaatact aatggtcaaa
     2941 taatgtcttg gatggttgat gagtacaata aattaactgg acaaagttct ataggtgtta
     3001 taactggtaa gccagttgaa tttggtggtt ctttaggaag aacagctgct actggatttg
     3061 gtgttgctgt tactgcaaga gaagctgctg ctaaattagg aatagatatg aaaaaagcta
     3121 aaatagctgt tcaaggtata ggaaacgttg gttcttatac agttcttaac tgtgaaaaac
     3181 ttggtggtac tgttgtagct atggctgaat ggtgtaaatc agaaggttct tatgctatat
     3241 acaatgaaaa tggtttagat ggtcaagcta tgttagatta tatgaaagaa catggtaact
     3301 tattaaactt cccaggagct aagagaatat ctttagaaga gttctgggct tcagatgttg
     3361 atatagtaat accagctgca ttagaaaact ctataactaa agaagttgct gaatctataa
     3421 aagctaaatt agtttgtgag gctgctaatg gaccaactac tccagaggct gatgaagtat
     3481 ttgctgaaag aggaatagtt cttactccag atatattaac taatgctggt ggagttacag
     3541 tttcttactt cgagtgggta caaaacttat atggatacta ctggtcagaa gaagaagtag
     3601 agcaaaaaga agaaatagct atggttaaag catttgaatc tatttggaaa atcaaagaag
     3661 agtacaatgt tacaatgaga gaagctgctt acatgcattc aattaagaaa gttgctgaag
     3721 ctatgaaatt aagaggatgg tactaagatt tactcttaat aaataatagg atataattat
     3781 ttaagatata aaggggctgt acatagtaca gcccttaaat tatgtggctt acaatgaagt
     3841 aagctatttt tgttttaact tataaataac ttgataaatt atgtaattta gaatgtattt
     3901 tttaccacca catgattaca aattagagga gttagattga atttttagac atgaacttat
     3961 gcattttaaa agcaaagacc ttaatttaaa gtatctagta ttatttttaa aaatagtata
     4021 ttggtttaat ccatttatat gtataatgga aaaatatatg gatttggatt gtgaacttta
     4081 ttgtgatgag agagttttaa aaaattgtac tgtacaacaa aagcaagaat atgctctaac
     4141 tattgtaaat tcaatgaaaa gaagtacaaa tttttcaaat aaatttgtag ctggattaaa
     4201 taaacaatct gatattagaa aaagagtaat aaacatgttc agtgaaaaac ataaaaatgg
     4261 tatcttaagg gctttgatta taagcttgtt ttcttctatt acatttttta aattcgattc
     4321 aactagtatt attgaagaga atgatttctt agagaggtca agatatacgt ttgaaggaag
     4381 gcaagaagac atgtttgtaa caatagattt tatatatgca gatgtaccta taaaacttag
     4441 aaaagagcat gaagaaaact gtagagtcaa tggaatagta ccaaaagatt cagattcaat
     4501 agaaattatt cctagatttt ataaagattg tatggattta aaaaaataag ttagacttaa
     4561 tattgatgtt gatattatga attttttata tttaagcaat tgaaaatttt attatagatt
     4621 caattttata tgtgtttaag tatgaaattt atagatagtt gaaataatta aatatgattg
     4681 atgcatagga atcattacta agctataatt aattataggg gagtttaaat aaattatgag
     4741 ttacacaatc ataaaatgat aaaaatagtt atctgttaca aaaaatgtat ctttttaatt
     4801 aataaagata atatgaaaac ttaaaaggca aataaactta aatataaaat actcttaaat
     4861 aagataggag aaaaatgtat gtctaacttt attctaaatg ggatttttag aacagttata
     4921 gtaagtagtc taagcattct tctgatattg attttcaaga aaaatgtatt taaaagattt
     4981 agcaaaaaat ttaattatta tatatggatg atagttgtta ttaaattatt tttaccattt
     5041 acatattata cttttacaat aaatatcttg agaagtaaaa aacacattaa tattaataac
     5101 ataaatttag agggatttaa taatgtttca actataagta ataatattat attgtacact
     5161 tggattataa ctgtagtagt gtatttaatt tacactatat ttaaatatat aaaacttaaa
     5221 aatttaataa atgacttatc ttatgatgtt gatgatagag agattgtaaa tctttataaa
     5281 aatatattag aagaatttaa tataacaaaa gatataaaac tcaaatactc ttatgaagtt
     5341 gaaacaccag cattttttaa ttcatgtgta cttttgccac cacatgagta taaattgaaa
     5401 gagttagact ggatttttag acatgagctt atgcatttta agagtaggga cctttattta
     5461 aaatatgtaa tcctattttt aaaaacagta tattggttta atccatttat atatataatg
     5521 gataaacata tagatttaga ttgtgaactt tattgtgatg aaagagtttt aaaaaatcga
     5581 aattcagagg aaaaaaagga ttatgcttta acaattctaa atgcaatgag aaaaggttca
     5641 aatacttcaa ataaatttat agctggactt cataagcaat ctgatattaa aaagagagtt
     5701 atgaatatgt ttaatgaaaa gtacaagaat ggtatattaa tggcattaac tttatgttta
     5761 ttatcttcta ttactttttt gaaggttaat tcaactagta ttgttaatct taatgtatta
     5821 cctaaaggat ttgaagactt acgaactgtt agcagtatac gtttttcagt tataggattt
     5881 acatatgcag atgctcctaa aaatatgagg gaagaatata aaataaattg tgaatcatta
     5941 ggtttgatac ctaaagactc tgataaaata gaagttggta tagaatatta tgacagtcta
     6001 ttgaatgatt aaataaatat tattttaaca gatattaatt ataaagtttt gaatagtaat
     6061 ttgttgagaa ataaatatat ccttataaaa atagatactt atataccaag aataaaaaat
     6121 agtcaagata gtacacaagg atatacttat aaagaactta aataagtgaa ataaattatt
     6181 aattataagg tttataattt taaaaaatta gataaattca ggtgtaaaat actataaaac
     6241 acaattcgga aaagtgtatg ttgaacttca tttaaaatgg aatttcaaag ttgctatagt
     6301 aagtagttta agcattcttc ttatattaat ctttgagaat aatgtattta aaaaagttag
     6361 taaaaaattt aactattgta tattaatgat agttgctatt gatatattat ctaaaaaaat
     6421 taagtatgaa aagattactg ctaggacaat cttttcatac ttaattttta atatttatat
     6481 tatccaaaat tttcatcttt ttaacttaga atttgagaat cactattagg aaataggctt
     6541 tgatttatgt agggttaaaa atttcacaga atatctaact ttatactaaa tccatcaaaa
     6601 aatatacgcc atacaaaagc gcataaaaaa acacataaaa caatatttat gcgcacttta
     6661 acctcgaatg gtacaaaatt ctttactttt acagacccat attatataat taagtaaata
     6721 atgtatattt aggtgacata ttggataagc taatttattt attttattaa tataataata
     6781 ctataaaagt tatataaagt ggtttacaaa aaagttacag atagagcttt tattaatgta
     6841 ttgtgtatta gtattttatc cttaggtaca cttcacctac aaaatagaat cataagataa
     6901 ttatgggaaa attttaggag gtttatcgtg aagaaaaaga tattaatacc agtatttgca
     6961 tcagttatgg cattatcagt aagttcaatt gtaaatgcag atgaagtaaa tgattcatct
     7021 caaaataagg atgataaaac aaatactgaa ttaaatttag gtgaatataa agaagtaaaa
     7081 tataaagttg caaaaataaa agatggagta gctataaaga taagagaaga aggtcaagtt
     7141 caaaacatag cttattctgg agatgaattt acggttttag gaactcaagg agaatgggtt
     7201 aaggttaaag ttgaagatgg cgaaggttgg ttagctacta gatatgtaga tatatctgaa
     7261 ggtgtaggat atactaacgc tgataaagta aacttaagaa aagataagag tgaaagttca
     7321 gaagtaattg aagagctgga aaaaggaagt tctttattgg ttttggaaga taatggagat
     7381 tggttaaaag ttaaagatgg ggaaacagaa ggatatgtaa aatcatctta tatatctgat
     7441 aaagctcctg taatagaaga gccacaagta aacccaagta ttgaccaaaa tgtagattct
     7501 acaaataata atcaacaaaa caatgcaaat actaatcaac aaaataataa ttcaaatgtg
     7561 ccaacagcta actctaatgc agttcaagct gtacttaact tggcatattc taagcaaggt
     7621 tgtccatatg tttggggagc agaaggacca aacacttttg actgttctgg atttacacaa
     7681 tatgtgtata gaaatgcagt aggaaagaat ataccaagaa catctaaagc acaatctaaa
     7741 tatggacaaa ctgtaagtaa agcaaattta caaccaggag atttagtatt cttcacaact
     7801 aatggttctg gttctgttag tcatgttgga atatatgtag gtgggggtaa tatgatacac
     7861 tcaccatcaa caggaaaaac agttagtgta actagtataa attcatcata ctatacagca
     7921 agatttgtta cagcaaaaag aatattataa tcggtttgta atatgacaaa ttgataaata
     7981 cataaatata tataaacgct ctatattata tttaatttaa tcatggaaac aaaataatga
     8041 ttatatttta aatgtactat agagcgtttt tgtatcactt taaatctaat caagattcaa
     8101 gttaatatga ctgttaaata ggagcctttt catatgatga ttatttgtgc aatcccttga
     8161 caggataggg taaaggtggt aagctactaa cagtacaaaa atacttttaa ttttagttca
     8221 gagaggctaa aaaaggagga cgaaagatgt taaaatcaag aaatttaatc caaccagaag
     8281 acttttcaat agaagaaata gatgaaatat tagaattagc tcaaaagata attgacaatc
     8341 cgtcaaaata ttctcgtata tgtgaaggaa aactattagc tacattattt tatgaaccat
     8401 caacaagaac aagattaagc tttgaatctg ctatgaacag attaggagga cgtgtagtag
     8461 gcttttcaga gccaaattca tcctctgcat caaaaggtga aactctagga gatacaatga
     8521 ggatagtatc tggttatgtt gatataatag ctatgagaca tcctcaatca ggtgcagctt
     8581 cagaagcagc tagatatacg gaagtgccat ttataaatgc aggagatggc aaaaaccagc
     8641 atccaactca aacacttaca gacttactta ctataaaatc attaaaagga actttagaaa
     8701 gccatacaat aggattatgt ggtgatttaa aatatggaag aactgtgcat tctttggtta
     8761 aggctatggc aagatataaa aatacaaagt ttgtatttat agcacctgaa gagttaaaaa
     8821 tgccagatta tataaaagaa gctataaagg gacatgcata ttatgaaact aataatttgg
     8881 atgatgttat aggaagcttg gatgttttat atatgactag agttcaacaa gaaagatttg
     8941 aagataaatc agagtatgaa agacttaaaa actattatat tttaaataaa gctaaattag
     9001 aaaaggcgtc taaagatatg ttagtaatgc atccattacc aagagtaaat gagatagaca
     9061 tagatgtaga tagtgatgat agagctgtat attttaaaca agctaaatat ggaatgtatg
     9121 ttagaatggc tttaataata aaacttttag gtataaatga agactaatag ttatcatata
     9181 atagtaaaac aaaggagatt ttgggatgta taaaattctg gaaaatatat atataggcga
     9241 agatatgtat agaatgaaag taaaaggtaa ttttgaaggt aaaatgggac aattctatat
     9301 gttaagagca tgggatactt atccagtact ttcaagacct ataagtatac atgatataga
     9361 tgaagaaggg ataacttttc tttataaagt agtaggagaa ggaactcaaa ttttgagtaa
     9421 cctaaaggta aatgatacta taaaattgga aggcccttat ggtaatggat atgctaaggt
     9481 tgatggaaag gtagctctag taggaggagg aatcggtgta gctccactat atttggttgc
     9541 taaaaatata aaaaattgtg atgcatatct tggctttaga gaagatgtta tattagaaga
     9601 tgaatataaa caagtatgta ataaagtata tacaacagta ggaaatactt ttgtaacaga
     9661 tataattgat gttgagaaat atgattatat attaacatgt ggtccaactc caatgatgga
     9721 aaaattagtt aagatggtag aaggtactaa aacgagaatt atggtatctc ttgaaaacca
     9781 tatggcttgt ggagtaggtg cctgtttagt atgtacgtgt aaaactaatg gaggaaataa
     9841 aaagacttgt aaagatggtc cagtgttctg gggagaggac gtgattttta atgggtaatt
     9901 taagtgtgaa atttggaagt gtagaattta aaaatccagt aataatggcg tctggaactt
     9961 ttggatttgg aaaagaatat aatgagattt atgatataca aaaacttggt ggtataagta
    10021 gcaagggtct tactttaaat aaaaaacctg gtaacaatgg tatgagagtt catgagacac
    10081 catccggtat gatgaatagt gttgggcttg aaaaccctgg agttcaagga tttatagact
    10141 atgaattacc tttttttagt aaactagact tagtcagaat agctaatgtt ggaggtggga
    10201 cattagaaga ctacttatta ggggttcaaa tgttaaatga caagcctata gacattattg
    10261 aattaaatat atcttgccca aatgtcaaag ctggtggaat ggcttttggt ataaaaaatg
    10321 aagtggcaag agaagttgtt cgtgaggtaa gaaacataac gaaactgcct ttagtaataa
    10381 aattatcacc caatgcagaa gatattgtag gaatggcaaa agtttgtgaa gaagaaggtg
    10441 ctgatggagt ttcattagtt aatactttta aagcaatggc aattgatata aaaaatagaa
    10501 gaccagtatt tgaaaatgta tatgctgggt tatctggacc agctataaaa cctatagctt
    10561 tgagaatggt acatgaagtg tgtaaaaatg taaatatacc tgtaatggga atgggcggaa
    10621 taactaaagc cacagatgct atagagttta taatggcagg agctacttgt atccaagttg
    10681 gaactgcaaa ttttatgaat cctagaatag gtattgaaat aatagatgga attaatgaat
    10741 ttatggatag agaaggaata aaaagtttag acgaaataag aggaattata taaggtagaa
    10801 taaatagtat tttaaagata aaaaatatag attaaataaa caataatttt ataacattaa
    10861 catggaggaa aaataatatg agtaaagtag atgtagtgga tatattaaag aaaagtgatg
    10921 cattgttgga gggacatttt ttattatctt caggaaaaca cagtaataga tacgtacaat
    10981 gtgcaaaagt attaagattt ccagaatatg ctgctgaggt attaagtaca gttgttgaac
    11041 aaataaaaga cttagatata gacttagtag taggaccagc tatgggtgga gtaatagttt
    11101 cttatgagtt aggaagacaa ttaggaaaag aagctgtatt tactgagaga aaagacaata
    11161 caatggagtt aagaagagga tttgaagtta aaaaaggagc aaagataata attgctgaag
    11221 acgttgtaac tactggtaaa tcaactatgg agacaaaaag agtattagaa gccttaggtg
    11281 gagaagttgt aggtgttgca tgtatagcag atagaactaa tcatgatata ggtatgccta
    11341 tatatagtgc tataaaactt gatattcaag tttatgaatc tgatgagtgt cctttatgta
    11401 aggaaggaaa attaccagtt gttaagcctg gaagtaggga gttcaaggaa ttagggatgt
    11461 aataaaaact taattattta tagtgttact taaaaaatgt aaatttttta gagtaaaaat
    11521 ttgtaatata acatataact taaaaataaa aagcagttag ccttataaat gaaggttagc
    11581 tgtttttttt gttaaaaata tatttacaaa ataagagata gtagcagtac aatataagta
    11641 taaggtaaaa gtattatata ttagggaggg gtaagtatga aaaatcaatt aaatgaaaat
    11701 cataaaaagg ttgtattttt tggagtaggt gctgtaggag ctacttttgc agaacaattt
    11761 tttaactcta aatatgattt taaaattctt tgtgataatg aaagaaagaa aagatattta
    11821 gaagaaggat ttataataaa tggaaaaagg tatgattttg attatgtaac taaagatgag
    11881 tataaacaag aggctgattt tataattata ggtctaaaat ataataattt aaaagaaaat
    11941 ataaaagaat tagatggatt agttggaaaa aatacagtta taatgtctct gctaaatgga
    12001 gttgatagcg aagagataat aggagaaaga tttggaattg aaaaaatggt atattcatat
    12061 gttaccaata tagatgcaaa gaaaatcaat aataatatta tacacactac taatgggata
    12121 attgtatttg gtaacaaaga taatagtgaa gatagaaaaa ctaatataat aaccgaagtc
    12181 tttgatgatg taaatataga atatacttta tcaaaagata ttcaacgaga tatgtggtgg
    12241 aagtacatgg ttaatattgg tgtaaatcaa acttcagcta tacttggtgc accttatgga
    12301 gtttttcaga gttctgagca tttaagagaa ttagcaaaat ctgcaatgag ggaagttgtt
    12361 gctatagcac aagcaaaaga catatctctt acagaagatg atgtggaaca ttcattacat
    12421 agaatactag aacattcaaa agaaggaaga acatcaatgc ttcaagatgt ggaagctcat
    12481 agacttacag aagtagatat gttttctaag aatatctgca aacttggaaa aaaatataac
    12541 atacctactc ctataaatca gactttcttt tatatgataa aagtaattga aagtagattt
    12601 taaagggtct ttgtaagaaa tattgataat tattgatttt aaattttatt aatgttatat
    12661 actatttaag ttactaaata tttttaactc ttcaatgaaa atagttgctg cttttgataa
    12721 agttatatct tttggaaata tatatgagaa atgtctgttg tagctgcttc caagctctat
    12781 gacagacagc tcattgttta gaacaggtaa gcttgtcact agattagaga ctattgtaat
    12841 tcctaaatta tttctaacag attctttgac agcataatta cttccaaaaa ccatcatact
    12901 ttttggaata atttctttaa cacttaaaaa catatctaaa taatctctgg ttccagaacc
    12961 atcctccctg actatccatt tttggttttg aagtttatca aaactaaaat cttttaataa
    13021 atgactcttg tatggaagtg ctaaaaccat cttatcttca aaaaaatatt cttgaataaa
    13081 tgaaggggaa gagcaagtgc cttcaataag accaatgtct aaaatataat ccttaacatg
    13141 agaagatacg attgatgtat tttttataaa aacttctaca tctatgtcag gatacttttt
    13201 agaaaataat gctagaaaat ttggtaaaat atactctcca atagttaaac ttgcaccaat
    13261 ctttaagtga ccagttatag catctgaaac ttggcttaca tcatgataag taatatttaa
    13321 aagatttaat atttctttag ctcttttgta caagatttgt ccactttctg ttataaaaat
    13381 ggttttttgt ttaatagacc tgtttataag cacaacttta aaataatttt ctagattttt
    13441 tatgtgttta cttacacttg gttgtgatag atttaaatat tccccagctt tagtaaagtt
    13501 tttgtattca acaacagcta caaatgtttt taattcttca aacaattttt tgtctccttt
    13561 acctaatgaa attttacatt ttttatatac tttctacaga taattatact atatataata
    13621 accattaaaa acattaatca ttacgatatt atatatttat tttacttatg gttattacaa
    13681 ttatatacta ttgctatgaa gaaaactata ttaattataa ggtaggtata ttatgttaaa
    13741 gaaaaaaagc agtttgacat taaaaactat aagggaaata ttaccaggac tgtttgtatc
    13801 agtattagta ggttatatta gtatatttat ttctatttta attcctaagg taggggcagc
    13861 atcaatttct atatttttag gtatgtttgt aggaaaccta tttttaaatc aaaaggtatt
    13921 tcaaaaaggt tataaatttt cagagacaga tttgttatca tattcaatag tactattagg
    13981 agcaacactc agtgtatcta ccttaataga cttaaaagtt tcaggaattt tatttataat
    14041 attgcaaatg acaataacaa taatagctgc actttatata ggtaaaaaac taggatttga
    14101 agaaaacttt agatttctaa tggcaagtgg aaatgcagta tgtggttctt ctgcaatagg
    14161 agcaacagtt ccagtggtta atgcgacaga taaagaaaag ggaattgcag taactattgt
    14221 aaatgttact ggtatatttc ttatgttttt acttccaata atatctcaat ttttatatag
    14281 ccatgaactt gtaaaaactt cagcaatgat aggtggaact ttgcaatcaa ttggtcaggt
    14341 tgtagcaagt ggagcaattg ttggagaaaa tgtaaaagat ttagctacta tttttaagat
    14401 agtaagagta atatttctag ttgttgttgt attagtattt ggacatatga aaaatcaatc
    14461 taatagggaa attcttgaag aagaaaagga tgagataaaa aagaaaaaag tgactatacc
    14521 atggtatgta attggattct ttataacttg tgcacttttt tcaatgaaca ttataccaca
    14581 agaagtatct gtgttgtgca aagaaataag taacaaacta gaaataatag ctttagcagc
    14641 aattggatta aaggttaatg taaaagattt agtgaaacaa gggaaagaag tttctttata
    14701 tggtttattt gtaggtatag tacaagttgt atcagctgta gttttaataa aaatatttat
    14761 atagcataaa aatagtattt gtaatattaa tttgattaat taaaataata tgatactaat
    14821 aatttataat ataaataaaa aatgaatttc gataagttta agtgggtata aacttataga
    14881 aattcatttt ttatttaagg taaaaattta aagtaaaata ttattttaca taataataac
    14941 cttataaatt ttgaaattac ttatctttgt gttaaaataa gtaaaatgca catattagag
    15001 ctaagttttt aagtaaataa acaaaatgaa aatataaata ttaaggagat ttggtatatg
    15061 aatgtttatg aaaaaggtaa tggagttata ctagaaggag taacagattt tgacccagta
    15121 catatatttg agtgtggtca atgttttaga tggcacaaac aagaagatgg ctcatacact
    15181 ggagttgcaa aggggagaat attaaatgtc aaaaaagaga atgataaaat atatttaaat
    15241 aatactaatt taaaggagtt taacagcatt tggtataatt actttgattt aggaactgat
    15301 tatacagaaa taaagaataa gctaaaaaat atggatgaat atttaaataa ggctactgaa
    15361 tttggatggg gaataagaat attaagacaa gatggatggg aaatgcttat atcatttata
    15421 atttcctcta ataataggat tcctatgata caaagagcta tagaaaattt atcaagaaaa
    15481 tttggtaagt atataggtga atatgaaggt aatgaatact atgcattccc aacaccagaa
    15541 gaactaaata aggcctcaca agaggaaata agagcatgtc aaacaggttt tagagataag
    15601 tacataaaaa gtactacaca ggcagttata gagaataatg atgaggtatc tgaatataca
    15661 aatttaagta ctgaggattg tagaaaagag cttttaaaat ttaatggagt aggaccaaaa
    15721 gtatgtgatt gtattgcatt atttggtatg caaaaatatg attcttttcc agttgatgtt
    15781 tgggttaaga gagttatgca agaattttat atagatgaag acatgagttt acctaaaatg
    15841 agaacttatg gaatcgataa atttaaagaa atgtctggat ttgctcaaca gtacttattt
    15901 tactatgcaa gagaactcgg tataggaaaa taaattaagg gggagaaatt atgggagtaa
    15961 taggaacaat atttctgttc tatttaatta tatcatatct agctggagcc ataatttctg
    16021 tgattatatt gcttgaaaat agagaccctg caaaaacaat gtcttggcta ttgatgttta
    16081 ttatatttcc aggtgtaggt ttaatgatat atgctatttc aggtagaaat attagaaaaa
    16141 gaaaattatt taagactcaa aaactagcta ataatataaa agaaaagaaa ctatttgata
    16201 cattagaaaa gataacagaa atagttgaat tagaaaaaga atctataaaa caaaataagc
    16261 ttttaagaga tgaagaggat ggtagttata gaaaaagggt aataaatatg ttgttaaaga
    16321 ctggtatgtt tccctttact aaaaataata aagtggatgt atttgtagat ggaaatgaaa
    16381 agtttaaaag acttatagaa gatataagag aagccaaaga ccatattcat ttagagtact
    16441 ttatcatcaa agatagtgaa ataggtaggg tgttaaaaga agaacttata aaaaaggcta
    16501 aagaaggcat taagataaga attttatatg atgatgtagg atgctggaga ttttggttta
    16561 atagaaaatt tttccgagaa atgagggaag taggtataga aattgcagca tttttaccta
    16621 caaaatttcc tataatagga gggaaattaa actatagaaa tcacagaaaa attgttgtta
    16681 ttgatggaat aattggatat acaggtggaa taaatatagg agatgaatat ttaggcaaaa
    16741 atgataagtt tggatattgg agagatactc atattaggat taagggtatt tctgtataca
    16801 tgcttcaaat gacatttctg attgattggt attatacgac aaaagaagta ttagtgacta
    16861 aaaattattt cccaagtgta gggaatgttg gtgaaagtat gatacaagtt gttgcgagtg
    16921 gtccagacag tgactgggaa gatattcatt atgcttattt ttctgcaata tgtcaggcta
    16981 gaaaaaatgt ttatatagaa actccatatt ttattccaga tgaaagtcta ctaaaagcta
    17041 taaagagtgc tgctcttagt ggagttgatg tgagaataat atttcctaaa attgcagacc
    17101 acaagatagt aaatatagca tcttattcat attttgaaga aatattaaga gcaggtggta
    17161 aagtttattt atataataaa ggatttatac attctaaagt cgtaataata gatgataaaa
    17221 ttgcttctgc aggtacagct aatatggatt taagaagttt tatgcttaac tttgaggtaa
    17281 atgcatttat ctatgatgaa gaagttatta gggtaatgac agatgatttc tttgaggatt
    17341 taagtcactg tgaagaactt aatttggagg tatttaagaa tagaaatatc atacaaaaaa
    17401 tcaaagaatc tgtagcaaga ttattttcac caatattata aaaaattatt aaaaaaggta
    17461 ttgaaaatta tgtgtgattg gtatattata ataattgtta gcactctatt agatagagtg
    17521 ataataaata aaaagtatat atataaatct acatatataa gtagtattaa tttaaaaata
    17581 actaaaaaca taggcgaact agtctatact taatatttta ggaggcgtga ataatgaaaa
    17641 taagaccatt agctgacaga gtagtaatta aaaaagtaga agcagaagaa aaaactgcaa
    17701 gtggaatagt tttaccagga gcagctaaag agcaacctca aatagctgaa gttgtagaag
    17761 ttggaccagg tggaatagtt gaagggaaag aaataaaaat ggaattgaca gtgggagata
    17821 aggttatatt ccaaaaatat tctggaacag aagttaagat agaaggacaa gaatacacaa
    17881 tactaagaca gagtgatgta ttagctgtta ttgaataaat atagaataaa tttattagga
    17941 ggggtttaaa atggctaaag aaattaaatt ttcagaggaa acaagaagag ctttagaagc
    18001 tggtgtaaat aaattagcag atacagtaaa agtaacatta ggacctaaag gaagaaatgt
    18061 tatattagat aaaaaatttg gttctccact tataactaat gatggagtaa ctatagcaaa
    18121 agagatagaa ctagaagata gatttgaaaa tatgggtgct caattagtta aagaagtagc
    18181 aactaaaact aatgatgtag ctggagatgg tactacaact gctacagttt tagcacaagc
    18241 tataataaga gaaggtttaa agaatgtaac agcaggggct aacccaatac ttttaagaaa
    18301 aggaatacaa aaagcagtaa cagtagcagt agaagaatta aaaaatcaat caagaatagt
    18361 agaaacacaa gaggctatat ctcaagttgc ttctatatct gctggtgatg aagaagttgg
    18421 aaaattaata gcagaagcta tggaaatagt aggtaaagat ggagttataa ctgttgaaga
    18481 gtctcaaact atgaatactg aattagatgc tgttgaaggt atgcagtttg atagaggatt
    18541 tgtttctgca tatatggtta cagatgtaga taaaatggaa gcagttttaa atgacccata
    18601 tatattaatt actgataaaa aaatatctaa catacaagaa ttattaccag ttcttgaaca
    18661 aatagttcaa caaggtaaaa agttattgat aatagctgaa gatgtagaag gtgaagcatt
    18721 atctacatta gtagtaaata aattaagagg aacatttgat gtagtagcag ttaaagctcc
    18781 aggctttgga gatagaagaa aagaaatgct tcaagatata gcaatactta caggtgctca
    18841 agtaatatca gaagaattag gttatgattt aaaagaagct gatttatcta tgctaggtag
    18901 agcttcatct gttaaggtaa ctaaagaaag tactacaata gtagatggtt ctggagataa
    18961 aaaagctata gaagatagag taactcaaat taaacatcaa gtagagcaaa ctacttcaga
    19021 ttttgataga gagaaattaa tggaaagatt agctaaactt gctggaggag tagctgttgt
    19081 aaaagttgga gctgctacag aagtagagtt aaaagaaaga aagttaagaa tagaagatgc
    19141 tcttaatgca actagagcag ctgtagaaga aggaatagta gctggtggag gaactgcttt
    19201 tgttagtgtt ataccagcaa taggaacact aattgagagt ttagaaggag aagttaaact
    19261 aggtgctcaa atagttaaaa aagcgttaga agagccatta agacaaatag ctataaatgc
    19321 tggtcttgaa ggtgctgtaa ttgtgcaaaa tgttgttaat tctgaagcag aaactggatt
    19381 tgacgcattg aatgaaaaat atgtaaatat gatagaagct ggtatagttg acccaactaa
    19441 agttagtaga agtgctttac aaaatgctgc atcaatagca agtactttct taactactga
    19501 agctgctgtt gctgaccttc ctgaaaaaga agatgtagga atgccaggaa tgggtggcgg
    19561 aatgcctggt atgatgtaat ttaaaaaatt taaaatataa attttaatat aaagaactat
    19621 ttcgacttag attttaaact ctaagttgaa atagttcttt tgtatatatc taatttttgt
    19681 atatctataa attcaataca catatttaga taatcagtat ctagtttgta ataatatttt
    19741 agagtagtat tgttattttt taggttatga ttttagatat atattaatta aggtataatt
    19801 gttgatagag aataaatcaa atttaaaagg atgcgataat atggacttaa gaaaattgct
    19861 tgaagaagtt aaaaatgaaa atattgatat agattttgcg ttagaaaagt taaaagattt
    19921 accttatgaa gaccttggat atgcaaatat agaccatcat agagaattaa gaaatgggta
    19981 tccggaagtt atttattgtg aaggtaagag tgatgagcat attttaggga ttattgataa
    20041 aatgaatcaa aaaagttcta acatattggg gacaaggtgc agaaaagaaa cttttctgaa
    20101 aattaaagaa atctataatc atgctgagta cgaagaggcg tctaaaattc ttaagattca
    20161 aaatcatgat atagagaata taggaaaagg taaaattgtg attgctacag ggggaacttc
    20221 tgatatacca gtagcagacg aagcttatca tacagctaag tttttaggta atgatgttga
    20281 tagaatatat gatgttggag tggcaggtat acataggctt ttaaataaaa gacataaaat
    20341 agatagtgct agagtaatag tagccgttgc aggtatggaa ggtgctcttg caagtgtaat
    20401 tggtggactg gttgatgttc cagtaatagc tgttccaact tctgttggat atggagcaaa
    20461 ttttggagga ttagcagcat tactagctat gttaaatagc tgtgcatctg gaatatctgt
    20521 tgtaaatatt gataatggat ttggagcagg atatttagca tcaatgataa ataaactgta
    20581 aatacattga tataaattaa acaaaactat ataataaaat ttaatttcta ttatattttt
    20641 actattaaaa ttgaggagac atatatgagt gaaaaaatac tttattttga tataataagc
    20701 ggtatatcag gggatatgac ccttgcaagt ttattaaatt taggtgtgcc taaggaaatt
    20761 tttttggagg aaattcataa actaagaatg agcgatgaat ttaatataaa catcagctcg
    20821 aaaactgaaa atggaatagt aggtacaaaa gtagaagtaa ttacaaaaga aaaacataca
    20881 catagaaatt tagtggatat atttgaggtt atagataaaa gcactctaaa cgaaaatgta
    20941 aaatctaaag caaaaaaaat atttatggta attggagaag cagaagcaaa agttcatgga
    21001 actacaatag acaagataca ttttcatgag gtaggggcta tagattcaat tgtagatata
    21061 gtaggagctt ctatattagt tgacttactt tgtgtagata aagtttgtgc tagtacagtg
    21121 tctgttggtt caggatttgt aaaatgtgaa catggaatta tacctatacc tgcacctgca
    21181 actatagaaa ttttaaaagg tgtgccaatt aaattaaata atgtaaatgg agaatgtaca
    21241 actccaacag gagctgcaat cataaaagtc ttgtgtgatg agtttgtaga tgagcttgaa
    21301 ttttctccaa agcaaattgg atatggtata ggtcataaga agtttgaagt accaaatata
    21361 ctcagaactg tattaggtga aaaaaaaaag aagaattaat ttatgaaatt agtgcaaaca
    21421 ttgatgatat gtcttcagaa atctattctt atttgtatga aaaaatatta gatgagaaag
    21481 cattagatat ttatacagag agcatttata tgaagaagaa tagaccagca acaaaagtat
    21541 caattttatg taatgaatca gatttagaaa aatttattaa aatattactt ttagaaacta
    21601 gtacttttgg agtgagatat aatgcatata atagagaaat tctagagaga aaatttgtaa
    21661 aattagatac aaaatatgga gtggttacag taaaactagg gtattataaa ggaaaactag
    21721 tcaaggctac tccagaatat aatgaatgta aaactatagc aaaaaatgaa gatattccta
    21781 taaaaaaagt gtttgctgat ataaatttta gaataaaaga agaatttagt gaaaacttat
    21841 tgacataagt aataaatttt gataaattaa tattcagcct tattaaataa aagtaaacag
    21901 aaaaaaatat ataaaatata aactcactcg tatatgctca gaaatatggt ctgagagtct
    21961 ctaccaagat accgtaaata tcttgactat gagtgaaatt attataccaa aagacctagt
    22021 taagtaaatg tgtaggctga gttaaactcc ctatgtgttg gctataagat aaaggtattt
    22081 tggaagcctg tatagtaatt tcacttttgc tagaaattat ggaagttact atacaggttt
    22141 tttgtgtaaa aagatttaat ataatttaga ctgtattgtg ttaaaataaa tatataaaaa
    22201 ctatattata caaggagaga tgtaaattta tgaaacatga attagtactt gtaatagatt
    22261 ttggaggaca atataatcag ttgatagcta gaagagttag agaaaacaac gtatattgtg
    22321 aaatacttcc atgtactgca agcatagaaa gaataaaaga aaaaaatcct aaagggataa
    22381 tatttacagg cggtccaaat agtgcgtatt tagaagattc tccaacaata tcaaaagaaa
    22441 tatttgaact aggagtacca atacttggaa tatgctatgg tattcaaata atgtctcatg
    22501 tattgggtgg agttgtaaga aaaggtaata aacaagaaaa agaatatgga aaaacagcta
    22561 taacttatgg aaaatcatca ttatttgaag gaataactac aaatagtgta tggatgagtc
    22621 atacagattt aatagaaaaa gttccagaag gatttactat agttgcaaat actaatgatt
    22681 gtccagtagc agctatggaa aatgtagaac gaaacctata tggagttcaa ttccatccag
    22741 aggtagaaca ctgtttggaa ggggacaaga tacttacaaa cttcttatat aatatttgta
    22801 aagtaaaagg tgactggact acagattcat tcatagaaga taaaataaaa gaattaaaag
    22861 aaaaaatagg cgataaaaaa gctttatgtg ctttaagtgg aggagttgat tcttctgttg
    22921 ctgcagttct tattcataaa gcaattgggg acaacttaac ttgtatattt gttgaccatg
    22981 gtttacttag aaaaaatgaa ggaaatgatg tagaaagaat atttagagag aaatttgata
    23041 taaatttaat aagagttaat gcagaagata gattcttatc taaattaaaa ggagtttctg
    23101 aaccagaagc taagagaaaa ataataggtg aagaatttat aagagtattt gaagaagaat
    23161 caaataaatt aggaaaaatg gatttcttag tacaaggaac aatctatcca gatgttatag
    23221 aaagtggaca tggaaatgct gctactataa agtctcatca taatgttggt ggaatcccag
    23281 aagatgtaga cttccaagaa attgtagaac cattaagaga gttatttaag gatgaagtta
    23341 gaaaaatagg attagagctt ggtatagaag aaggattaat atttagacat cctttcccag
    23401 gaccaggtct aggaataaga gttataggtg atgtaactaa agaaaaatgt gatatattaa
    23461 gagaagctga tgctgtttat atggacgagc ttagaaaagc aggtttatac agagaaatat
    23521 ggcaagcttt tgcaacatta ccagatgtta agactgttgg agttatgggt gatgaaagaa
    23581 catatgctta tttagttggt ttaagagcag ttacttcttc tgatggaatg acttctgact
    23641 ggtataagat gccttatgat gtattagaaa gaatttctaa tagaataata aatgaagttg
    23701 atggagtaaa tagagtagtt tatgatataa cttctaaacc tcctggaact attgaatggg
    23761 aatagtaaat aaaaaagtcg taagccttgt attttcaagg tttgcgactt ttaaaaaaat
    23821 ctttgtgata ctaaaatgat actatatatt taaattatct agtttttggg caacttcaag
    23881 ttgcttattt gggtataaat gtgaatatgt attccaagtt gtttctactt tttcatgccc
    23941 caatctttct gctatagtta atatatttac atccatattt accaataatg acgcatgaga
    24001 atgtctcaaa tcatgcactc taattctttt tacattagat aacttacagc atctatctag
    24061 ctctttagaa agataacttt tagcaaattt aaatattctt tcattatctt ttaagtcata
    24121 tagcttagat agataatctt ttatattatt atataagaaa tgtgggatag ggacaacacg
    24181 tttactttta ggagttttag gagaagaaac aatatcctct ccatttagtc ttatgtagct
    24241 tttttcgacg cttattttat tttcgaaaat atcttttgga gtaagagcta acaactcccc
    24301 tagtctaaga cctgtccaaa ataaaatttc aaatgctagt ctaggttctg atttcttttc
    24361 aaattcaata aattttttaa actcttctaa tgtccaaaag ttcatttcat ctgcgttttt
    24421 tttaccgata gaacctgcca aatgagcagg attagaaggt aagttataat atttaactgc
    24481 ataatttaat acagcaacaa gctggttgtt tatcgtttta atatatgttt ggctataatc
    24541 actttttaat aattcgtttt gccatcttct tatatgtgtt gcagtaattt catttatttt
    24601 tagactttta aaaaaaggta aaattctaaa gtttattaaa tactttttag tttctaatgt
    24661 agataatttt aatctagaag acatatcgtg catgtattct tctatgagac tttcaaaact
    24721 catatcagta ctcattttag atttattcaa aaattctctt tcaaactcta gagcttcttt
    24781 tttagtttta aaacctctct taattttctt tttcctatcc ccatcgaagt ctgtaaaata
    24841 aaagctagca taccaacttt ttctttgttc gtctttgtaa gcaggcattt tagacacccc
    24901 caattatgtc attttaatat tacaataatt ataacatgtt agatatgcta tctaaataat
    24961 tgttttattt tcctcttctt tttatttctt gaagcttgta atatttacac agttctaaga
    25021 agtcttcttc tagtgctata gataagtcta atatcgtaga tatacctata tctttgtact
    25081 cttgattttc tagttttgat atataacttc tgttacgtct cattttttct gctaattcta
    25141 gttgtgtcat tcttttcttt tttcttaatt ttttcaacat ttattaaaat ccacctttta
    25201 attattttta tgacattttt ataattaata gtttgtgtaa tttcttgtaa aaaatgttcc
    25261 tcattagaac attttttggt ggaaaaatgt gttaaaatgt aagtaagaaa agcactttca
    25321 aagcactata aaaatagtgc tgaaatagat aaacaaataa aagtaataag gaggaaagat
    25381 agattctaga gggaaatcat tatcattttt aagaacgtat gttcggttgg tgggatagaa
    25441 aaatacttta caggggatgg tttatttgaa tgagaatgaa aatatgagtt tatatgtcag
    25501 taagttaaaa gaagtattga aaaataattc agaagagtat aaaaaaataa gagctaaaat
    25561 aaatgaaatt tataatctaa atgaaaagaa agaataaaag ggctttagct cttttattct
    25621 ttcttagtat taactgcttt ataataagca ttatctatca ttttttttat tgcattttta
    25681 tcatctgaat ctaaagatgc taatctattt attagttcgt taacttcatt atcttctttt
    25741 gagttaactt tttttaataa ttcatcatct tgttgagtgt taggttgtat tttacctaat
    25801 ttagttaata gctcctttaa agttaaattt aatccaaaac tcattttttc aagcatatct
    25861 aaagtaggtt caacagcttt accattcctt gggtctctgt ttttttctat cttatctata
    25921 tatgtatggc tcacaccaca aagattagaa aattctctaa gagataagtt atgttcactt
    25981 ctatattctt taataatttc tgctaatgtt tgcataattt cacacctcat ctaagtaata
    26041 gttgacttaa ttatatcaga aaaatgtaaa ctattgttaa caaaaataaa aatttagtaa
    26101 aaaataattg acaagagtaa aaaaaagacg tatactatga ttaacaaaaa ggttataaat
    26161 aaagttagga gggattaata taaaaaataa tttacaatat attagaaaag aatctagaat
    26221 atcacaaaaa aaattcgctg ataagatagg tatatcaaga ccgtatttat ctagaataga
    26281 aaacggtaag gttaatccga gtttagaaat agcgcataaa atctcgctcg aaacagggaa
    26341 aacaataaat gaaatttttt ttgattttac tgtaaatcat agtaaactat aaggttttaa
    26401 ttgtaccttg aaaactaaat ataaaatatt ttaaaggagc aagtatatga aaaataaaga
    26461 aaaagaaata atcattagag gaattttaat aggaattttt tattttttag gaattgtatt
    26521 tagtaatact ttttttaaat aataaataga aggggtaggt gaaataccaa ctccccaaat
    26581 caaaataaca ctttggaagt taaatataaa atattcaaaa gaggtgatta gatgcaaaga
    26641 gagcaaacaa cgcttcgtat accagaagac ttgcacaaag cgttgataga tttaagcagt
    26701 gatataggaa tgcctattac atctattata ataattgcat gttggttgta tatatcaaag
    26761 ataaattaac caatccgata tgcaaaatga atgcacaaca ttatttatta gagaattgat
    26821 tgataaatta ttttctttag ctgttttctc tagcaactct tttaggacac caggaatcct
    26881 aagagtagaa cgaacagtat catcactttt atacgagatt gattgaagtt cattaacttt
    26941 tgaatttcta ataatatcat taatagcgta tagaataagc gaagatttga gaatgcctgt
    27001 ttgataagaa attttttcta aattttcatt taatggtgta tatattctta cagtaatagt
    27061 agtcattttg acacctccct aatgacatta tacaaaaaat atttaaaaaa gtcttgacac
    27121 taaaatagtg tcataatata atgattatag acagtaaaac agtgtcataa ggagggagga
    27181 ataagaatgg aaaaagtaag aatgacagta aggctcgtcc caaaattaaa tcaatatgta
    27241 cagaatatag ccaaagaatg tggaaaaagt aaaaattcta ttattgtgga tgcatgttgg
    27301 gagtttattg agaaaataaa aaaagaaaat aaattcaatg tagaaagcga ggaataaata
    27361 tgaataatct acagatattt gaaaaattgg aatttggaca aataagaatg gcagagattg
    27421 ataataagcc ttactttgta ggaaaagatg ttgcaaagtc attaggttat aaaaatacta
    27481 atgatgcaat tttaagacat tgcaaagggg tagtgaaaca cgaggggttt aaaattaatg
    27541 gtattaagat tgctttgata actgagggtg atgtttatag attaatagta ggttcaaatc
    27601 taccaaatgc agaaaagttt gagagttggg tgtttgatga agtgcttcca agcataagag
    27661 aaacaggtca ataccaagca caacagcatg taataacaga acttacagga actataggag
    27721 acttaaaagg aacaataaaa gaatataaaa agttgtgtaa gataacatgc tctaagaaac
    27781 aacagtattc taaatacata aagaatagac tggatataga caaagctaat aaagaataca
    27841 accaagtgaa agcaaggcta ttcctaattc ttggagttga gaagtgggaa gacatagact
    27901 tcgatacatc taataattta atacaaatta tagatgattg tataagagtt ataaagtcag
    27961 agagaccata caagcagttg agttattttg aaaactaaat acagaatatt ttgaaatata
    28021 ttgttttaat taattattaa ctaggaggtt aaatacatga aaaataatat aagcgattca
    28081 agagtaaaat atttttgcaa gtgtccatac tgtgggtttg ataatgaggt agaagttaaa
    28141 aaaggattga agcctaaaat atgttgcata tgtacaaaag aagttgagta tgaaaaactg
    28201 gagcaacaaa gtactccagc aaaataaaat taataaatat gaatattttt acaagaatct
    28261 aattcttttt ctaacttatt aacagcatgg ttatattgca gtgcctgttc tgctataaag
    28321 ttagaatttg atatgtgttc tttacacata gggcatggta gcccattatc acaaacttcc
    28381 ctaaatttag attctgttat ggtaactttt gtaccacaat cgaaacaagt agcttcaatt
    28441 ttagttattt taccgatatt cataaatcac cacctaatca tatatttata ggatttatcc
    28501 tacaaatata gtatatcaaa ggagggaaat aatggcaatt aatgacaaca taaataaaat
    28561 tttaagagat agaaatttaa aagcgtggaa attagcaaaa gaaataggcg tagattcagg
    28621 aaatttatat gcaattttaa gaggagaaaa taaaaatcca actatagata cattgataaa
    28681 actagctgac tatttagatg ttacattaga cgaattagtt ggaagataga aattaaatac
    28741 agaatatttt gaaagtaggt gtattgtatg gcaaaagcag tagctaaaga acaattgttt
    28801 tatagggcaa aagatatagc taagatttta gatgtatgtg aagcaaccgc ttataaaata
    28861 attggagaat taaataaaga attagaaaaa gaaggtttta agactttttc tggcagggta
    28921 tcagttgctt attttaaaga aagatattgt tataagccaa gaaagggggt gatttagttg
    28981 aatgtaaaag gtactaatag cttatataca gttttgcaat gataagcaaa taaaagcaag
    29041 ttttgaaggt cttagaaaat acaacagaga tatagagtta gttaacttgt atttaccaag
    29101 taaattaaaa ataaataagg aggtctaatt gtatatggta tttaatttag agaagttcaa
    29161 agtgggaaat gcgataagaa taagttgtga aagatttggt tttgaaattg attgtattgt
    29221 agtagtagca acagaaaaag aattaaattt agcatacttt gatgaaggta gaggctgtat
    29281 ggagtatcaa gccttaataa cagaagatat tcaagatggt gattatgaga ttaaaatttt
    29341 atcttaggag gaaataaaat ggcagcttta ataatggtag gtttatttgc aatatgttta
    29401 gtaggattag tacaaaatag agattaagtg aaggggtgta tttagatgga agcagctaga
    29461 ttaatagcaa tgggtcaaat taaacaggct gaaaaagaaa taagtaaatt gcaaggtaca
    29521 aaaaacaata gtagtttaat gtggtgggaa gccgtaaaat ttgctagtca aaatatatta
    29581 caagggttgg aacatgatat agagctagaa gcatcaactg atttcaggga gtttatgata
    29641 acacaagaag aacttgaaag agatagacct atagatgtgc agatataaga aaagagccta
    29701 gggtgaggct caattcaaat aaatattaaa aaatttaatt aagctaatta tagcataaac
    29761 ggagggaaat tatgagtact ttatatgaat taactacaga tttattagaa atagaagaag
    29821 gtttaacaga aacaacagga aatgaagctg aaaaactaga ggaaataaaa gaaataataa
    29881 aacaagagat acaaaataaa aacactagga tagtttcagt aatattaaac attgacagtg
    29941 atataaactc tatagattca gagattaaaa gattgcaaga gttaaaaagg gtcaaaaaga
    30001 atactcttga tagattaaaa agcaatataa aagactgtat ggaattactt ggtactaaaa
    30061 aagtagaaac agttttagga aatataagta taagaaagtc agcaggtagc ttagtcatag
    30121 aagatgaaga aaagatacct gctatatata aaacagtaga gcaagttgta aaagtagata
    30181 agaataccat taaagatttt attaaaaaag gtcatgaggt tgaaggttgc aggattgaat
    30241 atggaactac actaacaatt ccaaaagcta aaaaagagta ggtgaggacc atggaaatta
    30301 ataatattta cattaaattg atggatgtaa gagttaaatt tagtaagttg aatctaaaga
    30361 aaagtggaga aaataagttc gctaacttca agtattttga gttagcagac tttctaccac
    30421 aagcaactgg attacttgaa gaagctaagc tatgccctat agtgaccttt acaaatgaat
    30481 atgcaactct aacattaatt aatggagaaa acccatcaga acagattgta tttacttctc
    30541 ccatgagaga tttacaactt aaaggttcta atgaattaca ggcactagga ggtatagaaa
    30601 cctatcaaac tagatatttg tatattcagt tactaaatat aactgaaaat gatagttttg
    30661 acgcagtaag tggaaaagag gaatctaaaa gcaattctaa taacaatgtt aaacaaagta
    30721 acagaatatt gactgataaa caactaacta gattatatgc aatagctaat agtgttggag
    30781 ttaataaagc attattaaaa gaacaggttt ttaaacagct aggaaaagat ataaaggatt
    30841 taaataagag tgaatatgat gctgtttgtg cagcatatga gaaacaagcc tttaagggtg
    30901 cataacagga ggtgatagag tggcagtttt cagacagata tatacaagct tttggactga
    30961 cccaaaggta caagaggagt ggacaccaga agataaattt ttctttatac ttcttcttag
    31021 taatcctcaa acaacacaaa taggagttta ccaagtaact aaaaaacaac tagcattttg
    31081 gatggggtac tcagaagaaa gtataagagc attaatggat agattcgtaa atcaccataa
    31141 gtgtattaaa tataatcccg atactagaga aattgccata aaaaactggg gcaaatataa
    31201 cttaactaaa ggtggtaaac caattataga tttacttaat aaagaactca aagaagttaa
    31261 agatattgag ttaataaaat atgtaattcc atcaatagaa aaatcagata taagaaaaat
    31321 atttgaggat tattacgaaa tggctaaaaa tggggattct tacgatacgt cgacgatacg
    31381 tgaacgagtc gtaccacgat acggggacaa taacaataag aataacaata agaataacaa
    31441 taagaataac aacaacaata aggatgattc ggtggttgtg gataaaataa aacaatactt
    31501 tgatttagaa tctaaagaca ttgaaaaaat tgttgatata ttcatacata caggaagagg
    31561 aattgactat ttagaggaaa aactaaggtt ggtaaaaaat acagatggag taaaaagtat
    31621 tacaggctat ctcataaaag cattagaaga agattataag cctataccaa gtagaaaaaa
    31681 taagactaag tttcataatt ttaacgagac atttactaag tatacgtctg atgaactaga
    31741 cgagattatt aaaaagagtc aaaaagagaa gttcagttga attaaatagt ctagggagta
    31801 gttatacaat attacttcct aggagttaaa aaatattgga gggatagaaa tgataataat
    31861 tagaagtcaa gatagattag atttaatgag agttaataga gttgaaatag gttttaatca
    31921 agtgtatgca atacttgaaa atgatattag aaaaataggt gaatatgaaa gtattgaaag
    31981 agctatgcaa gtgttaaatg atatacagaa gtttattgaa aatggagtaa gaacagatta
    32041 tatagattct tgtagagtta gacataatca agagaaagta tttgaaatgc catttgaata
    32101 aaaagggggg aactaaatat ggctaaggtt tgggtggatg caggaacatt tttagaaaga
    32161 actaaggata tagaagatat gtttgaattt aatctaagaa aagtaagaga tagaaataaa
    32221 aaaataaatg taattgattt gcgtgtaaat aatgaggggc aaggaagaaa aggtaaaaaa
    32281 gtagagtgtt ttaatattgt gactggagaa actaaagtat ttaatactgc tgttgaagca
    32341 agtaaatacg tatattttac agatgtttat attgctcatt tagcaagaac aggtaaggtt
    32401 tctaaaaatg gatggaaagc tagatatatt caagaggtga cagatggtat tggcaaatgt
    32461 ggaacaagta attaagttag ctgaaaagat attaaataag aaaaagtgtt ctgttaataa
    32521 agctattgat atagttataa aaatattaag taaatatgag tgcgagggga tgttaagaaa
    32581 tgagtttaat taagtataga ggttatgatt ttgagaacga aaagtggatt tattcagcaa
    32641 caataatgtg gagcaatata cttgaatgtt tagttatgtt gacagagggt tgcaaatggc
    32701 agaaagtctc taatgttggg gtatgctctg gagaatgggc tagaaacaat caagaaattt
    32761 gtgaggggga tatattgaaa ggatatgata atttccatga cacaagccaa tatggagttg
    32821 taaaaaggga tattggtagt attaagttat atttggaatg gcattattta aagaaacttg
    32881 aaggagaatg gatagagctt ataaataaaa cagaaatata tcatagcaga gattacaaaa
    32941 tagttggtaa tgaatatgag aacttagagg aagtcagaac agagttctta gaacgtaagg
    33001 agagtcttga gaatgaatat cttagctagt gcgatattag taataggaag ttttatagct
    33061 ggtagagttt atgagtatag attgaatcta aaagagtgtg aaaattgcga caataaaaga
    33121 ggtgtataag aatggatgat agattagaaa tgataaatgc ttctgtaaat tatatacaga
    33181 tgatatgtga aagttcaaat atagctatta tagcagagcg aggaagagtt agaatattag
    33241 atttagaaac taaagaaaaa tatgatttat taaaaaataa actcgaggaa atgttagaag
    33301 aaatataagt gaaaatatct aattaagaca gtttagagag ttacaaaata tcttttagta
    33361 taaattattg ttgaagtgtt ttgtgactct caaaaatgaa aataaggagg cgttgtattg
    33421 cttacatttt tagatttatt cgcagggata ggtggcttta ggctagggat ggaaaaagca
    33481 ggacataaat gtttgggaca ttgcgaatat gataaattcg caaatttaag ttataatgcc
    33541 atgcacaaac cgaaggagga tgaatggttt gaaagagata ttagagaaat tagaacagaa
    33601 aatatcccaa gagcagatgt ctggtgtttt ggattcccat gtcaagacat ttctgttgca
    33661 gggaaacaat ttggattcag aggagaacgt tcaagtttat tttttacagt tacaaaactt
    33721 attagagaac tcaaagaaga agatagaccc aagtatttac ttattgaaaa cgttaaaaat
    33781 ctacttagtg ttaatggagg atttgatttc ctcaaagttc tcgttgaact ggatgaaatc
    33841 ggctatgatg cagagtggca agttcttaat tctaaaaact tcggagtacc ccaaaataga
    33901 gaacgaatat tcattgttgg acattttaga ggacgaagta cacgaaaagt a
//
LOCUS       DAEPID010000041        33012 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.041, whole genome shotgun sequence.
ACCESSION   DAEPID010000041 DAEPID010000000
VERSION     DAEPID010000041.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 33012)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 33012)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..33012
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.041"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            complement(<1..492)
                     /locus_tag="KR257_002179"
     CDS             complement(<1..492)
                     /locus_tag="KR257_002179"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889535.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="metal-dependent hydrolase"
                     /protein_id="HBH0030864.1"
                     /translation="MIKETHERGGYIFALLILPFINNLYLVKYDIAYKIVLIIIYIYF
                     AYLGSLFPDIDMRGSYISKKFMLIYKLFGSRFRHRGFTHSLIALLLIYSFFKSLTIFT
                     NNNIVFSCLSSGFIIGYLSHLCLDLITKEGIELFYPITINISLLPIKTNSKTEKFISK
                     LLNF"
     gene            complement(605..1279)
                     /locus_tag="KR257_002180"
     CDS             complement(605..1279)
                     /locus_tag="KR257_002180"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000094049.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="superoxide dismutase"
                     /protein_id="HBH0030865.1"
                     /translation="MSLFIISQCITSFAFTPENNKFKVKPLPYAYDALEPYIDKETMK
                     LHHDKHYQAYVDKLNAALEKYPELYNYSLCELLQNLDSLPKDIATTVRNNAGGAYNHK
                     FFFDIMTPEKTIPSESLKEAIDRDFGSFEKFKQEFQKSALDVFGSGWAWLVATKDGKL
                     SIMTTPNQDSPVSKNLTPIIGLDVWEHAYYLKYQNRRNEYIDNWFNVVNWNGALENYK
                     NLKSQD"
     gene            1482..3356
                     /gene="asnB"
                     /locus_tag="KR257_002181"
     CDS             1482..3356
                     /gene="asnB"
                     /locus_tag="KR257_002181"
                     /EC_number="6.3.5.4"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436426.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="asparagine synthase (glutamine-hydrolyzing)"
                     /protein_id="HBH0030866.1"
                     /translation="MDGNISIYYKGDISKKEDIKFKIKESVNNTRLSSRIEYKDEEKT
                     FDFERFNVIDAIYGNKPFEKDGKVIVFNGNIYNYHEIKEELIKKGHNFTTNDDIEVLL
                     ASYIEFGKNCVHKIKGMFNFIIYDRENESIFGARDLFGIKPLYYINKENAIIFSSEYK
                     FLLEYMKNLNINERSLQSYFSFQYVLPEDTMIQGIRLIPAGHYFRVENGILSLKRYNK
                     LEFRSSTKFFYTKNHLGNRDVNEDDIRNIVVDSIVTHMEEEKEIGTFLSGGIDSSIIT
                     TVASQINPNIKSFSAGFSVKGYSELEVAKKTADKLGIENIQINITQDEYIKSLPNVIY
                     SLDDPIADPSEVGLYFLIKEAGKHVKVALSGEGADELFGGYNIYKEYSTMKSVVNSPT
                     YIKSILGRVSELMPNIKGRNYLYRATTPLEKRYIGNAKVFENSEVKRFFFKYKEKNIY
                     EYLLSNLYRDAQKNNYDYISKMQHIDVNTWLQGDILQKISKLSTAEQVELRVPFLYKD
                     VFDVAKNLRMEQKINKNNTKVLLREAFREIVPEHVVQRKKLGFPTPIRVWLKDSLGDI
                     VKETIYNSNVDEFIDKKYAIKLLDTHLKGHRDNSRKIWTIFTFCLWHQLFIEHKNVEY
                     "
     gene            complement(3448..4884)
                     /locus_tag="KR257_002182"
     CDS             complement(3448..4884)
                     /locus_tag="KR257_002182"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728870.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="trypsin-like peptidase domain-containing
                     protein"
                     /protein_id="HBH0030867.1"
                     /translation="MICTIKPLKISIKKSTEPLIEFISDTTYKNKRSSYIKEVYFTRY
                     IGVDDSIDKYIEKIKNIDTYFFNNPTIPYIRLNNLKINFDKEQTDKMLKIFNIYNSSK
                     FNSWDLYNIDFPCKIENDTLNWTKKIAFKNTLDLFSTSMPNCTSSIIKNFAVKLLCWI
                     DYFLPKLFYNKVKTTISPKIVYFGNIKRQELFFLYFLSQLGCDILYINPNKDILDLYP
                     ECSKFSTLFELSRKTPNILEIPFERHITNINYSENTNKTSPTTNKPNSKNTLNNTNLT
                     SKKIVQDEEVELSYEDLAKLSASVVMIVVCNNENKPFKSGSGVVINNEGYILTNLHVV
                     NDGYSFLVRFENDDKVYTSYQIIKYHSDYDLAVIKVDRKCKPIPVKVSKKPVRGQKIV
                     AIGSPLGLFNTVSDGIISAFRDFETVQMIQFTAPISSGSSGGALLDMFGNLLGLISAG
                     YDDGQNLNLAVESNLVKIFANNFIEIVN"
     gene            5213..5791
                     /locus_tag="KR257_002183"
     CDS             5213..5791
                     /locus_tag="KR257_002183"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_126936537.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TerD family protein"
                     /protein_id="HBH0030868.1"
                     /translation="MGITLSKGQKVDLTKGNPGLKNILVGLGWDTNKYDGGFDFDLDT
                     AAFLTGASGSVTNDGDFVFYNNLKHTSGAVEHLGDNRTGEGDGDDEQIVVDLSKIPGE
                     ISKISFTVTIHDATERRQNFGQVSNSYIRIVDKDTNEELIKYELGEDFSIETAIVVAE
                     IYKHNGEWKFNALGSGFEGGLAALCGNFGINL"
     gene            5830..6408
                     /locus_tag="KR257_002184"
     CDS             5830..6408
                     /locus_tag="KR257_002184"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_126936537.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TerD family protein"
                     /protein_id="HBH0030869.1"
                     /translation="MAIVLKKGQKIDLTKGNPGLKNIKLGLGWDTNSFDSGYDYDLDV
                     SVFMVGESQRVEKDEDFIFYNNLKHPSGAVEHLGDNRTGEGDGDDEEILVNLETMPKH
                     IQKIAVTVTIYEAAERRQNFGQVSNSYIRVLNSENDEEILRYDLGEEFSIETAITVCE
                     IYKYNGEWKFSAVGAGFEGGLEALCRNYGLNV"
     gene            6494..7123
                     /locus_tag="KR257_002185"
     CDS             6494..7123
                     /locus_tag="KR257_002185"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728871.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TerD family protein"
                     /protein_id="HBH0030870.1"
                     /translation="MSINLSKGDKIDLKKSNPGLSNILVGLGWDPVQQSGGGFFKSLF
                     GGGQADIDCDASVFMLNQEGKLSGIKDLIYFGNLKSACKSVLHTGDNLTGEGTGDDEQ
                     ILVNLDKVPSNIHKLLFVVNIYNCVDRKQHFGMIENAYIRVEDQGNKKEIAKYNLSDN
                     YSEKTTLIVGAIYRKDGSWQFKAIGEGTKDAGLKEVMQNLDRIECAYGI"
     gene            7113..9872
                     /locus_tag="KR257_002186"
     CDS             7113..9872
                     /locus_tag="KR257_002186"
                     /EC_number="7.2.2.10"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420276.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="calcium-translocating P-type ATPase, PMCA-type"
                     /protein_id="HBH0030871.1"
                     /translation="MEFNNDIKYYNVDKEEVTKDLSVNPEKGLSESEVKTRREKYGLN
                     EFTPKEEGSFWDDLKESLSEPMIVILIIAAVVSAVIGETHDAIGIVGAIAIGIAIGMI
                     TEGRSKKAAEALSKLTENIEVKVLRDGEVHQISKSELVPGDIVYIETGDMVPADGRLI
                     ESINLKIREDMLTGESDDVSKKCDVVVSMEEIESKGAVVVQEPIPAKQINMVFGGTLV
                     AYGRGALVVTSIGDNSEMGKIAQNLSETDEQTPLQIKLGNLGGLIAKVSSAVAGLLFI
                     FMVFQMISKNVLNVDMSGILPFLESIDPVKTAFTVCVALIVAAVPEGLPTMINMTLAI
                     TMQKMAKINALVTKKEACETIGSVSVICSDKTGTLTENRMTVEVAYVDGRYIESSEEE
                     INSYFEENCMINSTADVEHNDGDIKYLGSATECALLLYYKNVDYRQVRKNSNIVAQNP
                     FTSDSKRMTSVIGQDNHHVLLSKGAPEVLLELCSHIQRGKDIVPLTENIKHEILEEIK
                     KLQIKSMRTLGFAYKEISQAEEEAAVTAESDAMNVSAMENNLVFSGFVGIRDPLRKDV
                     IESVNTANKAGVSVKMLTGDNINTARAIGEELGLLKNNMRVVEASYIDTLDDEELKQE
                     IQSISIVARSKPDSKMRIVSALQKSGDVVAVTGDGINDAPALSKADVGIAMGISGTEV
                     SKNAADIILTDDSFSTIVKGIKWGRGIYDNFQRFVQFQLTVNVIAFLVAIISQVMGQE
                     MPFTTIQLLWVNIIMDGPPALALGLEPVRDHVLNRKPVDRKANIISKSMVYTIVLNAF
                     YITAILMLQSTFNFLGVDEAHKGTVMFALFAFSALFNAFNCREFNADSIFPNFTHNKL
                     ALQIIVLTGIAQVIFTQLFQDFFNSVAMDFMTWVKVLCVAASVIVVNEVVKCIIRLVK
                     PKKTA"
     gene            9959..11521
                     /locus_tag="KR257_002187"
     CDS             9959..11521
                     /locus_tag="KR257_002187"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430080.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YceG family protein"
                     /protein_id="HBH0030872.1"
                     /translation="MGDSKVFEKIFSSQSDRGNYTPSKGYLSYFISYIGLEDEVLYNL
                     EIFKTKQNIDSKKDIALFTDVIANPSDFDIINYFKSGLQKYRTSMEDVDINILGFEEI
                     DYKIKQAMDRVLKEEEKEFTNDRVKQNFIVKIMAWIKIYIGALDINKNEAPKVIFYGD
                     IKKHEVYLLLILYLAGFDVLYLNPNSKSNIDILKSERYNIEFEEANIIEEKISFEERV
                     ILGEKIDKSSVKKAFTVGAEASKRISEELLNDAGFIKPWQLQDRKIKNLLLSSTVDEI
                     SIYWNQPLKLRPGFKFNDAIVEAPNFLSKINGIYNDKNEYIKFLDLLRDSESSTFIEF
                     NGDVDRFSKAFTREAFSLSFLLDSKGAIDKNSVLNNKDYSISTLALNQQIMILEKVEE
                     LLEGSMFLNGLSGEDKIKGLFTVLHMDKKFVHMMNNFDYSLINPKLIIYMYKSIVFDK
                     EIVFLMLLLSKIGFDIIILCPGGENNIENVINNQLIDVHRLDKMVYDLKLNSLENDIP
                     LLKKIFGKRRRF"
     gene            11522..12658
                     /locus_tag="KR257_002188"
     CDS             11522..12658
                     /locus_tag="KR257_002188"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430084.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="toxic anion resistance protein"
                     /protein_id="HBH0030873.1"
                     /translation="MGININSFSKDKNSVEVTENLPTAVQEENFDIMEYTNNKKNELR
                     KSKEVEALTSLIEVENPDTILQFGRKASEGVARVSDSLLNTIKLNRNEENSKMLVHLT
                     KIMDKFDLDDFQETKEPNFVQKLFKKANNAIEMMFQKYETLGGEVEKIQIELEQYERD
                     IALSNKQIGAMLNENFEFYNELQKYIVAGEMAIEEMDNEILPFFKQKSETSGDQMDVV
                     NYQELLKVYDMLNQRVYDLRIAENIAIQTIPMLRGMQHNNYGLIRKINSAFVVTLPVF
                     KQCLSQAILLKKQELQAKSLKALDDKTNELLLRNAQNVSTQSAQIARMAGTSSVQIET
                     LEKMYNTIKSGIDETMRIEENNRALIKDNTKRLEELNTTIIYNK"
     gene            12722..13798
                     /locus_tag="KR257_002189"
     CDS             12722..13798
                     /locus_tag="KR257_002189"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003433662.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HpcH/HpaI aldolase/citrate lyase family protein"
                     /protein_id="HBH0030874.1"
                     /translation="MKYFDYICKDDLERIFLKEPEDFSAKTEKDVLKYALGAFLYVPA
                     TQYNMIYKSIIGDVKGVRPLAICLEDAVGVNGELEAIENLRLILKNISNESITNKDGI
                     PLIFVRIKDVEQLLRIKEIIIKNRHSITGILIPKANSELIENCIEALDSMNLQDMYVI
                     PIIETKEFIYNEKKELSFTNLYNAILRHKSRILSIRVGITDILGMYGIRRDKNFSIYN
                     NLICSSFILDIITYLQRPELDIPISGGVSEFFDMTNKDIRNKYIEEILLDKYHGLIGK
                     TVIHPMQIQIVQALSTVSYEDFTDALDILDSTDSKYGVSKGVLGERMNETNPHFLWAK
                     KTLILSKIYGVLNKGVDYEELLKF"
     gene            13776..15014
                     /locus_tag="KR257_002190"
     CDS             13776..15014
                     /locus_tag="KR257_002190"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420284.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphoribosyltransferase family protein"
                     /protein_id="HBH0030875.1"
                     /translation="MKNCLNFNCEIDIIDNPLNLELNDFLDVGIRNNSKRRFLFISKK
                     LGKHLACKPSEMDNLGKLMATIYNEKNKEESNGTVIAFAETGTAVGHSFFDYLCGDYE
                     FIHTTREQFDELENLEFLEEHSHATDQNLYFGMLNNFKFGDEIILVDDEITTANTCMN
                     IIRKIQSIYPKKKYTICSILNWVSDENLSKVTRLERELDCKIDFVYLFKGNFKFYIDE
                     DIISNYNDNYSITKLETISSDKVNLVVNHIYVDLEDYIGNKKYVKYTGRFGINRREQF
                     RLKEIVKRESKKITMASKESLKNEKEKILFLGTEEFMYIPMLFAKEKENQYDIYYHST
                     TRSPIINIDKNNYPIKSKFMLKSFYNIDIQNYIYNIDKHNFSKCYLFVELNKSENSYL
                     EFIDIIKKTSIKELTIVCCS"
     gene            15068..16156
                     /locus_tag="KR257_002191"
     CDS             15068..16156
                     /locus_tag="KR257_002191"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902680.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cysteine protease StiP family protein"
                     /protein_id="HBH0030876.1"
                     /translation="MRDFSTYSKDDVIFLLKDISNLIEEEGNKERELKIQNGRHYSEM
                     IPIEYEVSEDYLNLYHEKLRENKDKLAFSIGVMCEKIIKKNGNDVVLVSLARAGTPIG
                     ILAKRYIRSKYNVSLPHYTISIIRDKGIDMNAIEYIVKNHPSSKIQFLDGWTGKGTIS
                     KELEKACDELNVKFKKYFDSTLAVLADPAGYSGLYGIREDFLIPSACLNSTVSGLVSR
                     TVLREDLISKNDFHGAKFYRHLKDKDESMNYIETIEECFKNQFKNISDEVENWESDII
                     TRDGYFDVLNIKEKYNITDINFIKPGVGETTRVLLRRVPYKILVKDLNDKSLDHIFIL
                     AKEKNVEVEQMDLKAYKCCGIIKNMKDI"
     gene            16184..16975
                     /locus_tag="KR257_002192"
     CDS             16184..16975
                     /locus_tag="KR257_002192"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889544.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HAD hydrolase family protein"
                     /protein_id="HBH0030877.1"
                     /translation="MIVFSDLDRSIIYSNKFLNADSKYANIEIYREKEISYISLDTIN
                     LIKQIQYYGMFIPTTTRTVEQFKRIEFNKYGIYFPWSITSNGGVILKDNEILKSWSEK
                     IDKLKSDYEPIESMIHKFKDYLNVDGITNFKVAEDTFFYIVVDLSRFNLDSIKEYTNI
                     LESKNWKFYVSGRKIYFIPKEISKENAIKYLTKELGIEYFYAVGDSIMDYGMLNISNK
                     SYVLKHGDINKNEIENSFISSSFNGMSGTEEILSNILDENCLLNI"
     gene            complement(17090..17644)
                     /locus_tag="KR257_002193"
     CDS             complement(17090..17644)
                     /locus_tag="KR257_002193"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420290.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cupin domain-containing protein"
                     /protein_id="HBH0030878.1"
                     /translation="MNIDVGSKIRSLRKSKNISISTLAKNSDLSTGLISQIERNMVVP
                     SIVAMWKISKALDINIGYFFEEIGREDSDIVVKKNNRKKIVTNDSTKFYELLVPNLSG
                     KKIEFILVTLDGHTHKNSEFVTHEGEECGYIIKGKMKITLGNKEYLLEEGDSFYFNST
                     IPHVYENYDDEVCISVWAMTPPSF"
     gene            17840..19042
                     /locus_tag="KR257_002194"
     CDS             17840..19042
                     /locus_tag="KR257_002194"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009905536.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF819 domain-containing protein"
                     /protein_id="HBH0030879.1"
                     /translation="MKSFVSPDNIWVLWAVVTGWAAFSIYLEQKYNWASKVSGAIIAL
                     VGAMLLSNLNIIPVESVVYDQVWGYVVPLAIALLLYQCNIKKIWKESGRLLIIFLVGS
                     VGTVLGAMIGFLALKNVVPDLNIVAAMMTGSYIGGNVNFAAMSGAFDAPGELVSATVV
                     ADNLLMALYFFVLIAIPSIGFFRKHFKHPHVDEMESIGITEGETVAANYWGRKEISLK
                     DIAIAIGSAFIIVAVSVELSTWFKAIIPLSNPFLAMLNTLFGNQYLIITTLTMLFATF
                     MPNFFGDIKGAQELGTFLIYIFFVVVGVPASITLIIQKSPLLLLYCGIMVLINMLVTF
                     IVAKIFKFSLEEAILASNANIGGPTTAAAMAISKGWSKLVGPILIVGTFGYIVGNYFG
                     LLVGNILI"
     gene            19099..20079
                     /locus_tag="KR257_002195"
     CDS             19099..20079
                     /locus_tag="KR257_002195"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889546.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptidase"
                     /protein_id="HBH0030880.1"
                     /translation="MIFDGHSDTWADVTIRRLNGEKDVFRRIHLDNFKRANIEGAIFV
                     IWIDPPYDKEPEKRVKQIISSIKDEIEDMKDVVNIVKKYSDIDKGISENKINILIGLE
                     GLSHIGRNIDLLDYFYKEVGARHASLTWNEQNELATGCLGDENRGLTEIGKKAVNKME
                     KLGMIVDVSHLNEKSFWDLMSVASKPVIASHSNARSLCDAKRNLTDNQLKEISNTGGL
                     VGINSFRGFTNSNPKKQDLIHLVDHIDYMVNLIGIEHVSFGFDFSDYLGKETIGSFTG
                     NASVPSVDGLESTHTAQNIVVELENRGYKKKDIELISSGNFYRLFKDILK"
     gene            20327..21280
                     /locus_tag="KR257_002196"
     CDS             20327..21280
                     /locus_tag="KR257_002196"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454520.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="iron chelate uptake ABC transporter family
                     permease subunit"
                     /protein_id="HBH0030881.1"
                     /translation="MKKRYLVIGIIILSYFSLFIGAEDINIMHIFAKNQHKLMIFIMS
                     RIPRLISILIAGVGMSIAGLIMQQISKNKFVSPTTGATIDAAQFGIVICMLLVPTASI
                     FTKTIIAFVFSLVGTFTFMKIIGKLQFKNIIFVPLVGIMFGNIIGSMTDFIAYKYDLS
                     QNVSSWMQGDFSMILKGNYEILYITIPLIILAYIYANKFTVVGMGMDFATNLGLSYKR
                     IVNIGLIIVALVTVCVVVTAGNIPFIGLIVPNIVSLYMGDNIRASIWYTGLLGAIFVL
                     ICDIFGRIIIYPYEISIGLTVGVIGSILFLYLILRRNVNEA"
     gene            21270..22226
                     /locus_tag="KR257_002197"
     CDS             21270..22226
                     /locus_tag="KR257_002197"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430100.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="iron chelate uptake ABC transporter family
                     permease subunit"
                     /protein_id="HBH0030882.1"
                     /translation="MKLSLNQKIYFVSILLFISIALFIIYGIDMNHLEYALSQRIPKI
                     FAMVLGGGCIAFTTVVFQTITNNQILTPSVLGLDSLYVMIQTIIVFIFGSSSSLIINE
                     NYNFIINVAMMIGASLLLYKTLFEKNKNNIFFLILVGMIFGTLFKSATTFIQVMIDPN
                     EFLALQTSIMASLNNINTNVLLIAFIIIIAIIPFIYDEIKYLDVLSLGKEQAINLGVD
                     FDKAVKKMIILIAILVSISTALIGPMTFLGLLLANITREIFKTYKHTYLISGSMLIGM
                     ITLIIGQFFIQHVFKFDTTLSVVINFIGGIYFIQLLLKGANR"
     gene            22223..22978
                     /locus_tag="KR257_002198"
     CDS             22223..22978
                     /locus_tag="KR257_002198"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003234487.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="HBH0030883.1"
                     /translation="MIEIKNIFKRYKNKNVVDDVSFSIEKGKITSFIGPNGAGKSTVL
                     SIVTRLIGGDGGEVIIEGKSLTNYSNKELAKKIAILKQSNNITLKLTIRELVGFGRFP
                     YSEGNLTKEDENYIDEAIEYMKLTDIQHKYLDELSGGQRQRAYIAMVIAQDTEYILLD
                     EPLNNLDMNHSVQMMKVLRSLCDELDKTIVLVMHDINFASCYSDNIVALKNGKVKKVG
                     RTDEIVNEKVLEDIYEMNFNIKNINGNRICIYF"
     gene            23070..24035
                     /locus_tag="KR257_002199"
     CDS             23070..24035
                     /locus_tag="KR257_002199"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893211.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="siderophore ABC transporter substrate-binding
                     protein"
                     /protein_id="HBH0030884.1"
                     /translation="MNKKAAIVAAVAIIGLVTVFALGGSKKNESKTSENSNNTMKITH
                     NLGETDVKLNPKKVVVFDYSALDTMDALGVAENLVGLPKASLPASLEKYKDDKYADLG
                     GLKEPDLEGIKSANPDLIIINGRQEDFYEQLSKIAPTISTSKDDKKYLESVKNNIDKI
                     AKIFGVEEKANQEFSKIEKKIETLNKKVTDKNLNALTIMVNEGNLSVFGEESRFSILY
                     NSFGFENKDKNIKESSHGQNITFEYIAKQNPEVMFVIDRGIATGSDVKESSTAKSVLN
                     NDIIKSMDAYKNDNIIYLDSPTWYVNDGGLTSLNKMIDDASKAVN"
     gene            24513..26372
                     /locus_tag="KR257_002200"
     CDS             24513..26372
                     /locus_tag="KR257_002200"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420306.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="EAL domain-containing protein"
                     /protein_id="HBH0030885.1"
                     /translation="MKRFLRRIILVLFILLIFISFISIKLIHNVGDYGKLINYVGIVR
                     GASQRLTKLEMNHQPNDELIEYIDEILQELITGHGDYGLVITDCNEYNEDLLLLEKKW
                     EDLNIEIKKVRMKEQNNQLLSISEEFFSLANDTVFKIENFSKEKSNYLMTLIIIISII
                     GILACIILILQYSKKMVRLEKLNVDLKNIAYKDELTGVNTIEKFKLDANQNICIHKDK
                     KFAVFYIDFENFKYINDIFGYDYGDMILKRYANLMMNDIGKYEIFAREIADRFVALRC
                     YVDKEDLVVRQRDVDNELINITNEIKNKHSITVVSGICCIEDVNEKLSIDGLINRANF
                     AQKTVKNKPGTNYAFYNDSIRKKMIEENTIKSRIHEAIEKREFIVYLQPKVNLHSQKI
                     NCAEALVRWLTPDKGIISPAIFIPVLEKNFFIALVDKYVFEEVCKWIRKRLDENKPFV
                     QISVNVSRIQFYNTKFVETYSNIQNKYRIPKNTIEIEFTESVAFENQKHLLEIIHDLH
                     ENGFTCSLDDFGKGYSSLSVLKDLPFDVLKLDSMFFKASLDKDKEKIVIKNIVHMLKE
                     LNITTVAEGIECKEQVEFLRDIGCDLVQGFVFYKPMPILEFEKILDKEFVYNS"
     gene            complement(26664..27263)
                     /locus_tag="KR257_002201"
     CDS             complement(26664..27263)
                     /locus_tag="KR257_002201"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454512.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TerD family protein"
                     /protein_id="HBH0030886.1"
                     /translation="MAIELKKGQKINLTKKENSDLGEILVNLNWNQKVQKKGFFGSLR
                     SSNIDLDLGCLFEMKNGVKGAVQALGNAFGSLDNPPFAQLDGDDRTGSNTQGENLRIN
                     GNKIKDIKRILIYAFIYEGVANWSEADGIVTIKQKQDSDLVVKLDEHKNGYNMCSIAL
                     IENVNDETFSVEKVVKYFKGHREMDTEFHWGLKWVAGRK"
     gene            complement(27366..28163)
                     /locus_tag="KR257_002202"
     CDS             complement(27366..28163)
                     /locus_tag="KR257_002202"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902687.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="lipoprotein"
                     /protein_id="HBH0030887.1"
                     /translation="MKFKKLLCLLLCLVLTLAVVGCSKAKDDKKIVVGATLVPGGELL
                     EELKPLIKEKGYTLEVKNFDDYILPNEALNNGEIDANLFQHEPYLKEAVKAKGYKIMA
                     GKKLYVCPAILYSYKIKSVDEFKKGDTIAISNNPSSCSKNLRYLESIGLLTLPKGDGL
                     VSPKDIIENPKGIQFKELDIAQIPSSLPDVTAAFIDTTYAVPAGLDAKKNGIYTAPIN
                     DEYANLLAFRTEDKDSEKIKVLQDVLTSDKARSLIEEKYKGIVIPTF"
     regulatory      complement(28276..28381)
                     /regulatory_class="riboswitch"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00162"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="SAM riboswitch class I; Derived by automated
                     computational analysis using gene prediction method:
                     cmsearch."
                     /bound_moiety="S-adenosylmethionine"
                     /db_xref="RFAM:RF00162"
     gene            complement(28473..29459)
                     /locus_tag="KR257_002203"
     CDS             complement(28473..29459)
                     /locus_tag="KR257_002203"
                     /EC_number="6.3.1.20"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889551.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="lipoate--protein ligase"
                     /protein_id="HBH0030888.1"
                     /translation="MLLIYNEKTNPYFNLAMEEYLLKNFDEDLFILWRNEPSIIVGKN
                     QNTLSEINLEYIKEYSIPVVRRQSGGGAVFHDLGNINFTFIACNNNNFSDFRRFTQPI
                     IDLLKTLDVNAEFSGRNDLLIDGKKFSGNAQYNYKNKVMHHGTLLFSSEINDLSKALK
                     VKPIKFEGKGIKSVKSRVTNISEHLHSKMDILEFKDAIMDYLSKTNTDNTNYCLSEHD
                     IKQIEKLTKSKYETWDWNFGNSPKYTLSNELKYSGGNVEFNLNVDKGIITSIKFFGDF
                     FGKCDVAFVENKLIGIRHEENALRNTLDSIEINDYFLGADTDILVSGILGVK"
     gene            29943..31673
                     /locus_tag="KR257_002204"
     CDS             29943..31673
                     /locus_tag="KR257_002204"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420315.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Na+/H+ antiporter NhaC family protein"
                     /protein_id="HBH0030889.1"
                     /translation="MRNKKINIIFLTTIMFIMSTVMVFAEEDIDTIALANAEKFGILT
                     LIPPLVAIILAFITKNVIISLLIGILSGSFIIKASGINVFATFIQAFLDLVDRALVSL
                     ADPWNAGIILQVLAIGGVINLVAKMGGAKAIAEALAKRAKSAKGTQLITWFLGLLVFF
                     DDYANSLIVGPMMRPVADKMKISREKLAFIIDATAAPVAGLAIISTWIGLEVGLIHDA
                     FESISIDVDAFGIFLNTIPFRFYNILILAFIVISALLLKEFGPMRKAEIKSRSRKISI
                     DLDEGVEELDDLAPKNGVKLSVWNAIIPIGTLIIVALASFYYSGYTSIMGGDDKALIQ
                     LFTNSPYSFEAIKEAFSASDASRALFQSALVASLVAIIMAVVKKIFTISEAIDVWIDG
                     MKSLVITGVILILAWSLSSVIKELGTAKFLIHLLSGSLPPFLLPSLIFGLGAIISFAT
                     GTAYGTMGILMPLAIPLAYSLNPDMSYVIVSTSAVLTGAIFGDHCSPISDTTILSSMG
                     AGCNHIDHVNTQMPYAIFTAVITIVFGYIPAGLGLPIYIVLPVAIAAIFVGIQIIGKK
                     VDEAEIELVE"
     gene            31783..31863
                     /locus_tag="KR257_002205"
     tRNA            31783..31863
                     /locus_tag="KR257_002205"
                     /product="tRNA-Leu"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:31817..31819,aa:Leu,seq:tag)
     gene            32198..32713
                     /locus_tag="KR257_002206"
     CDS             32198..32713
                     /locus_tag="KR257_002206"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861286.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HXXEE domain-containing protein"
                     /protein_id="HBH0030890.1"
                     /translation="MEKYIWLFPLLFIFHDMEEIIGFGIWLKKNKSMLDKKYPFISKV
                     YENYSTEGMAFAVFEEFILCIIFCILTVITENQYVYLLWLGSFIAYTLHLVIHIGQSI
                     IIRKYIPSLITSIICLPISIWCISKSIYIVDCEMSTTILYSIIGIIIVALNLKFAQSL
                     IGKFTKWMSNI"
BASE COUNT        12739 a         3620 c         5472 g        11181 t
ORIGIN      
        1 gaaatttaat agcttagata tgaatttttc tgtttttgag ttagttttta taggtagtaa
       61 agaaatgttt atagtaatgg gataaaacaa ttcaatacct tctttagtaa taaggtcaag
      121 acacaagtga gatagatatc ctattataaa cccactggac aaacatgaga aaactatatt
      181 attgttagtg aagattgtca gagatttaaa aaaactataa ataagtaata aggcaattag
      241 actgtgagta aaccctctat gtctaaacct acttccaaat aatttgtata ttaacataaa
      301 ttttttactt atgtaagaac ctctcatatc tatatctgga aataaagaac ctaaatatgc
      361 aaaataaata taaattataa ttaatactat tttatatgca atatcgtatt taactaggta
      421 cagattgttt ataaagggga gtatcaaaag tgcgaatata taacctcccc tttcatgtgt
      481 ttcttttatc atataaaaat cctcctgaat cgtcactata aacattatat tggtaaattt
      541 agactatctt ttattatatt atatagcaaa cataagtttt tttcaaaagg attttaatat
      601 ttaattaatc ttgagatttt aaatttttgt aattttctaa agcaccattc caatttacta
      661 cattaaacca gttgtcaatg tattcatttc ttctattttg atattttaaa tagtaagcat
      721 gctcccaaac atcaagtcct attataggag ttaggttttt acttacaggg ctatcctgat
      781 ttggagtagt cataatagat aatttcccat ctttagtagc tacaagccaa gcccaaccag
      841 aaccaaagac atctaaagca gatttttgga actcttgctt aaatttttca aaagaaccaa
      901 agtctctatc aatagcttct tttaaagatt cagaaggtat ggttttttct ggcgtcatta
      961 tatcaaaaaa gaatttatga ttataagctc cacctgcatt atttcttaca gttgtagcaa
     1021 tatctttagg taaagaatct aaattttgca ataattcaca taaagaataa ttataaagct
     1081 caggatattt ttcaagagca gcatttaatt tatcaacata agcttgataa tgcttatcat
     1141 gatgcagttt cattgtttct ttatctatat aaggttcaag tgcatcatat gcataaggta
     1201 atggtttaac cttaaatttg ttattttcag gtgtaaaagc aaatgaagtt atgcactgtg
     1261 agattataaa taaagacata ataactggta ttaatatttt tttcttcata aaaatcacct
     1321 cctaatatag tatttctaga aataaaaaaa atatgaaata ttaacagata atttataaga
     1381 atttaatagc aatttcattt taaattgaat aagttttaaa gccaaagaca aaactatgaa
     1441 atatagaata agactaaagg acagaaagga attttgatta tatggacggc aatatttcaa
     1501 tttattataa aggtgatata tctaaaaaag aagatattaa atttaaaata aaagaatctg
     1561 taaataatac aagactttct agtagaatag agtataagga tgaggaaaaa acttttgatt
     1621 ttgaaagatt taatgtaatt gatgctattt atggaaataa accatttgaa aaagatggaa
     1681 aagttattgt ttttaatgga aatatatata actatcatga aataaaagaa gaattaatta
     1741 aaaaaggaca caattttact acaaatgatg atattgaagt cttattggca tcttatatag
     1801 aatttggtaa gaattgtgta cataagatta aaggaatgtt caactttata atctatgata
     1861 gagaaaatga aagtatattt ggagcaagag atttatttgg gataaaacca ctctattata
     1921 taaataagga aaatgcaata attttttcct cagagtataa gtttttactt gaatatatga
     1981 aaaatttaaa tataaatgaa agaagcttac aaagttattt ttcatttcaa tatgtacttc
     2041 ctgaagatac tatgatacaa ggaataaggc tgataccagc aggtcactat tttagggtag
     2101 aaaatggtat actatcttta aagagatata ataaacttga gtttagaagt agtacaaaat
     2161 ttttttatac taaaaatcac ttaggcaata gagatgtgaa cgaggatgat ataagaaata
     2221 tagtagtaga ttcaatagta actcatatgg aagaggagaa agaaattgga acatttctgt
     2281 ctggtggaat agattcatct attataacta ctgtggcttc acaaattaat ccaaatataa
     2341 aatctttttc tgcaggcttt agtgtcaaag gatatagtga attagaagta gcaaagaaaa
     2401 cagctgataa gttaggtata gaaaatatcc agattaatat aacacaagat gaatatataa
     2461 aatcattacc gaatgtaatt tattctttgg atgaccctat agcagaccct tcagaagtag
     2521 gtctttattt cttaattaaa gaggcaggta aacatgttaa agtagcattg tctggagaag
     2581 gagcagatga attatttgga ggatataata tatataaaga gtatagtact atgaaatcag
     2641 ttgtcaattc acctacttat attaaaagta tattaggaag agtttcagaa cttatgccaa
     2701 acataaaagg aagaaattat ctttatagag ctacaacacc attagaaaaa agatatatag
     2761 gaaatgcaaa agtttttgaa aacagcgaag taaaaagatt cttttttaag tataaggaaa
     2821 agaatatata tgaatacctg ttgtctaatt tgtatagaga tgcacaaaaa aataattacg
     2881 attatataag taaaatgcaa catatagatg tgaatacatg gcttcaaggc gatatacttc
     2941 aaaaaattag caaactttct acagctgagc aggttgaact tagagtacca tttttatata
     3001 aagatgtatt tgatgtagca aaaaatttaa gaatggagca aaaaataaat aagaataata
     3061 caaaagtttt acttagagag gcgtttagag aaatagtccc agaacatgtt gttcaaagga
     3121 aaaaattagg atttccaact ccaataagag tttggttaaa agattctcta ggggatattg
     3181 taaaggaaac tatttataat tcaaatgtag atgaatttat agataaaaaa tatgcaataa
     3241 aacttttaga tacgcatctt aaaggtcata gagataattc gagaaaaata tggactatat
     3301 ttacattttg tctatggcat caattattta ttgagcataa aaatgtcgag tattaatact
     3361 tttttcaata ttaatcagag ggcaaaagca tgcaatgttt tcaccctcct gattattatg
     3421 gaataggata agtagaattt tgattgatta gtttactatc tcaataaaat tattggcaaa
     3481 tattttgaca agattacttt caacagctaa atttaagttt tgtccatcat catatccagc
     3541 ggaaatcaat cctagtaagt ttccaaacat atctaaaaga gctcctcctg aactaccact
     3601 agagattgga gctgtaaatt gtatcatttg aaccgtttca aaatcacgaa aagctgaaat
     3661 aattccatct gaaactgtat taaaaagacc tagagggctt ccaattgcaa ctattttttg
     3721 acctctcaca ggttttttac tgactttaac aggtattggc ttgcattttc tatcaacctt
     3781 tatcacagct aaatcataat ctgaatggta ttttataatt tggtaagatg tataaacttt
     3841 atcatcattt tcaaatctaa ctaaaaatga atacccatca ttgactacat gaagattcgt
     3901 aagtatataa ccttcattat ttattactac tccagaaccg ctcttaaacg gtttattttc
     3961 gttattgcac acaacaatca taacaacaga agctgataac tttgcaaggt cttcataaga
     4021 aagttctact tcctcatctt gtacaatttt tttagatgtt agatttgtgt tattaagtgt
     4081 atttttagag ttaggtttat tcgtagtagg agaagtctta ttggtatttt cactgtaatt
     4141 tatatttgta atatgccttt caaaaggtat ttctaatata tttggagtct tcctagaaag
     4201 ttcaaataga gtagaaaatt ttgaacattc aggatataaa tcaagaatat ctttatttgg
     4261 atttatatat aaaatatcac acccaagttg tgataaaaaa tataagaaaa aaagttcttg
     4321 ccttttaata tttccaaagt atactatctt tggtgaaata gtagtcttca ccttgttata
     4381 aaataattta ggtagaaaat agtctatcca acacaaaagt ttaactgcaa agtttttgat
     4441 gatagaggat gtacaatttg gcatacttgt ggaaaataaa tctaaagtat ttttaaatgc
     4501 aatcttttta gtccaattta aggtgtcatt ttctatttta catggaaagt cgatattata
     4561 taaatcccaa ctgttaaact tagaactatt ataaatatta aaaattttaa gcatcttatc
     4621 tgtttgttct ttgtcaaaat ttatttttag attgtttaat ctaatatagg gaattgtagg
     4681 attattaaaa aaataagtat ctatattttt aattttttct atgtatttat caattgaatc
     4741 atcaacacct atatatcttg taaagtagac ttctttaata tatgaagaac gcttattttt
     4801 ataggtagta tcagatataa attcaattag aggttcagta gactttttta ttgaaatctt
     4861 taatggttta atagtacaaa tcatattttt tctcctataa taagatgata taatctatta
     4921 taaaacaact taaaacaata tagtacaata attttgtagt ttcaaaataa aatatgtact
     4981 tgtttatata aatgatatat aattacatat taaacatagc ttttatgcat ttaataaagt
     5041 atgtaaaatc tatgtaaaaa gtaagaaata taaacatttt tttaattata ttttaaaaat
     5101 atcaagcaag ttttattcac aaatgaataa aaaatgttat aatatgatta aagaaaaaga
     5161 taaataatta gcaagatttg tttagctaaa attaacaagg gagcgataaa ttatgggtat
     5221 aacattatca aaaggccaaa aggttgattt aactaaagga aatccaggtc ttaaaaatat
     5281 tttagtaggt ttaggatggg atactaacaa gtatgatggt ggatttgact ttgatttaga
     5341 tacagcagca tttttaacag gagcaagtgg aagtgttact aatgatggag attttgtatt
     5401 ttacaacaat ttaaaacata catctggagc agttgagcat ctaggagata acagaactgg
     5461 cgaaggtgat ggagatgatg aacaaatagt tgttgattta tctaagattc ctggagaaat
     5521 aagcaagatt tcttttactg ttacaattca tgatgcaaca gaaagaagac aaaattttgg
     5581 acaagtaagt aattcttata taagaatagt agataaagac acaaatgaag agttaataaa
     5641 gtatgaatta ggagaagatt ttagtataga aacagctata gtagtagctg aaatatataa
     5701 gcacaatgga gaatggaagt ttaatgcact aggttctggc tttgaaggtg gtcttgctgc
     5761 attatgtgga aactttggaa taaacttata atttcaacta taacaataaa ctaaaggggg
     5821 atattttcca tggctatagt attaaaaaaa ggacaaaaaa tcgatttaac taagggaaat
     5881 ccaggtctta aaaatataaa acttggacta ggatgggata caaattcatt tgatagtggc
     5941 tatgattatg atttagatgt aagtgttttc atggttggag aatctcaaag agttgaaaaa
     6001 gatgaagatt ttatattcta caataactta aaacatccat ctggagcagt tgaacactta
     6061 ggtgataata gaactggtga aggtgatgga gatgatgagg aaatattagt gaatttagag
     6121 acaatgccaa agcatataca aaagatagct gtaacagtta caatatatga ggctgctgaa
     6181 agaagacaaa attttggaca agtaagcaac tcatatataa gagtattaaa ttctgaaaat
     6241 gatgaagaaa tattaagata tgacttaggt gaagaattta gtatagaaac tgcaattaca
     6301 gtatgtgaga tatataagta taatggagaa tggaagttta gtgcagttgg agcaggattt
     6361 gaaggtggct tagaagcact ttgtagaaac tatggcttaa atgtttaatt taagcaatat
     6421 aatatattaa atataaataa cctatacaaa taatgtatag gttatattat ataaaatttt
     6481 gtggaggttt agtatgtcga ttaatttatc aaaaggtgat aaaatagatt taaaaaaatc
     6541 taacccagga ctgagtaaca tacttgtagg tctaggatgg gaccctgtgc aacaatctgg
     6601 cggaggtttt tttaaatcgt tatttggtgg aggacaagct gatatagatt gtgatgcatc
     6661 tgtatttatg cttaatcaag aaggtaaatt aagtggaata aaagatttaa tttattttgg
     6721 aaatctaaaa agtgcctgta aatcagtttt gcatacagga gacaatctaa ctggtgaggg
     6781 tacaggtgat gatgaacaaa tcctagttaa tttggataaa gttccatcaa atattcataa
     6841 attattgttt gtagtaaata tatacaattg tgtagataga aaacaacact ttggaatgat
     6901 agaaaatgcc tatataagag ttgaagacca aggtaataag aaagagatag caaaatacaa
     6961 tctatctgat aattattctg aaaaaactac tcttatagta ggagctatat atagaaaaga
     7021 tggaagttgg caatttaaag caattggtga aggaacaaaa gatgcgggtc ttaaagaagt
     7081 aatgcaaaat ttagacagga ttgagtgtgc atatggaatt taataatgat atcaaatatt
     7141 ataatgtaga taaagaagaa gttacaaaag acttatctgt taatcctgaa aaaggtttat
     7201 cagaatcaga agtcaagact agaagagaaa aatatggttt gaatgaattt actccaaaag
     7261 aagagggtag tttttgggat gatttaaagg aaagtttaag tgaaccaatg atagttatct
     7321 tgattattgc agcagtagta agtgcagtaa ttggggaaac tcatgatgca atagggattg
     7381 taggtgctat agcaataggt atagcaatag gtatgattac agaaggtcgt tctaagaaag
     7441 cagcagaggc tctttctaag ttgactgaaa acatagaagt aaaagtattg agagatgggg
     7501 aagtacatca aatttctaag agtgaattgg taccaggtga tatagtatat attgaaactg
     7561 gtgacatggt acctgctgat ggtagactta tagaaagtat aaaccttaaa attagagaag
     7621 atatgttaac aggagaatct gatgacgtat ctaaaaagtg tgatgtagta gtttctatgg
     7681 aagagataga atctaaagga gcagtagtag tacaggaacc aatacctgca aaacagataa
     7741 atatggtgtt tggtggtaca cttgtagctt atggtagagg agctctagtt gtaacttcaa
     7801 ttggagataa tagtgaaatg ggtaaaattg ctcaaaactt atcagaaaca gatgagcaaa
     7861 ctccacttca gataaaactt ggaaatttag gtggtttgat agccaaagtt tctagtgcag
     7921 tagcaggatt actatttata tttatggttt tccaaatgat aagtaagaat gtattaaatg
     7981 tagatatgtc tggaatatta ccgtttttag aatcaataga cccagttaaa acagcattta
     8041 cagtatgtgt tgcgttgata gttgcagcag tgccagaagg tcttccaact atgataaata
     8101 tgacacttgc aataacaatg caaaaaatgg ctaaaataaa tgcattggtt accaaaaaag
     8161 aagcttgtga aacgataggt tctgtttctg taatatgttc agataaaact ggtacattaa
     8221 ctgaaaatag aatgactgta gaagttgcat atgttgatgg cagatatatt gaaagttcag
     8281 aagaggaaat aaatagttat tttgaagaaa actgtatgat aaactctaca gctgatgtag
     8341 agcacaatga tggtgatatt aagtatttag gaagtgctac tgaatgtgca ttgcttttat
     8401 attacaaaaa cgtagattat agacaagtta gaaaaaattc taatatagta gctcaaaatc
     8461 cttttacttc agattcaaag agaatgactt ctgttatagg tcaagataat catcatgtac
     8521 tattatcaaa aggagcacca gaagtcttac ttgaattatg ttcacatatt caaagaggaa
     8581 aagacatagt tccattaact gaaaatataa aacatgagat tttagaagaa ataaagaaat
     8641 tgcaaataaa atcaatgaga actttagggt ttgcatataa agaaatctca caagctgaag
     8701 aagaagcagc agtaactgct gaaagtgatg ctatgaatgt aagtgcaatg gaaaacaatt
     8761 tagtatttag tggttttgtt ggtataagag acccacttag aaaagatgtt atagagtctg
     8821 taaatacagc aaataaagct ggtgtttctg taaaaatgct tacaggagat aatataaata
     8881 cggcaagagc tataggtgaa gagttaggcc tattaaaaaa taatatgaga gtggttgaag
     8941 cttcatatat agatacttta gatgatgaag aattaaaaca agagatacaa agtatttcaa
     9001 tcgtggcaag aagtaaacca gatagtaaaa tgagaatagt ttcagctctg caaaagagcg
     9061 gagatgttgt tgcagtaaca ggtgatggta taaatgatgc tccagcactt tcaaaagcag
     9121 atgttggtat agcaatgggt atatctggta cagaggtatc taaaaacgca gcagacataa
     9181 ttttaactga tgatagtttt agtaccattg taaaaggtat taaatggggt agaggaattt
     9241 atgataactt ccaaagattc gttcaattcc aattaactgt aaatgtaatt gcatttttag
     9301 tggctataat atctcaagtt atgggacaag agatgccatt tactacaata caattattat
     9361 gggtaaacat cattatggat ggaccaccag cactagcatt aggtttagag ccagttaggg
     9421 accatgtgtt aaacagaaaa cctgttgata gaaaagccaa tataatttct aagtcaatgg
     9481 tgtatacaat agtattaaat gcattttata taacagcaat actaatgtta caatctacat
     9541 ttaatttctt aggagttgat gaagcgcata agggaacagt aatgtttgcg ttatttgctt
     9601 ttagtgcact gtttaatgca tttaactgta gagagtttaa tgcagatagt atcttcccta
     9661 attttacaca taacaaatta gcactacaaa taatagtgtt gacaggaatt gcacaagtaa
     9721 tatttactca gctattccaa gatttcttta actctgtagc aatggatttt atgacatggg
     9781 taaaagtttt atgtgtagca gcaagtgtaa ttgtggttaa tgaagttgta aaatgtataa
     9841 taagactggt aaaaccaaaa aagactgctt aaaacaaatt ttttagaaga aaacagactg
     9901 actcaaaata tgaattttgg gtcagttctg aataaacatt taaattggga ggatagttat
     9961 gggtgactca aaggtatttg aaaaaatatt ctccagccaa tcagatagag gaaattacac
    10021 tccttcaaag ggatatctaa gttattttat ttcgtatatt ggtttagaag atgaagtttt
    10081 gtacaatctc gagatattta aaacaaaaca aaatattgat agcaaaaaag atattgcttt
    10141 atttactgat gttatagcaa atcctagtga ttttgatatt ataaattatt ttaaaagtgg
    10201 acttcaaaaa tatagaacta gcatggaaga tgtagatata aatattttgg gatttgaaga
    10261 gattgattat aaaataaagc aagcaatgga tagagtgtta aaagaagagg aaaaagaatt
    10321 tactaatgat agagttaaac aaaattttat agtgaaaata atggcatgga taaaaattta
    10381 tatcggtgct ttagatataa ataaaaatga agctccaaaa gtaatatttt atggagatat
    10441 aaaaaaacat gaagtttatt tactcttaat attatacttg gcaggttttg atgttttata
    10501 tcttaatcca aattcaaaga gtaatataga tattttaaaa tcagaaagat acaatataga
    10561 gtttgaagaa gccaacataa tagaagaaaa aatttctttt gaagaaaggg ttattttagg
    10621 ggaaaaaata gataaaagtt ctgtaaaaaa agcttttact gttggggcag aagcatcaaa
    10681 gcgtataagt gaggaattgt taaatgatgc aggatttata aaaccttggc aactccaaga
    10741 tagaaaaata aaaaatctac ttctaagttc aactgttgat gaaatatcaa tatactggaa
    10801 tcaaccactt aaattaagac caggatttaa gtttaatgat gctattgtag aagctccaaa
    10861 ttttctttct aagattaatg gaatatataa cgataagaat gaatatatta agtttttaga
    10921 tttattaaga gattcggaaa gttcaacatt tattgaattt aatggagatg tagatagatt
    10981 ttcaaaagct tttacaagag aagcttttag tttatccttt ttattggatt caaaaggtgc
    11041 aatagataaa aactctgttt taaataataa agattattcc atatcaacat tagcattgaa
    11101 tcaacaaatt atgattttag agaaagtgga agagttgtta gaaggaagta tgtttttgaa
    11161 tggtttaagt ggagaagaca agataaaagg tctatttaca gtacttcaca tggataagaa
    11221 atttgttcat atgatgaaca atttcgatta ctcacttata aacccaaaat tgattatata
    11281 catgtacaag agtattgtat ttgataaaga aatagttttt cttatgcttt tacttagtaa
    11341 gattggattt gatattatca tattatgtcc aggaggagaa aacaatatag agaatgttat
    11401 aaataaccaa ttgattgatg tacacagatt ggataaaatg gtatatgacc ttaaattaaa
    11461 ttcgcttgaa aatgatatac ctttacttaa aaaaattttt ggaaagagga gacgatttta
    11521 gatggggata aatataaata gtttttcaaa agataagaac tctgtagagg ttactgagaa
    11581 tttgcctaca gcagttcaag aagaaaactt cgatataatg gaatatacaa ataataaaaa
    11641 aaatgaactg agaaagtcta aggaagttga ggcattgaca tctcttatag aagtagaaaa
    11701 tccagatacg attttacagt ttggtaggaa agcatctgaa ggagtagcaa gagtttctga
    11761 tagcctttta aatacaataa aattaaatag aaatgaagaa aattctaaaa tgctggttca
    11821 tttaactaaa ataatggaca agtttgattt agacgatttt caagaaacta aggaaccaaa
    11881 tttcgttcaa aaacttttca aaaaagctaa taatgccatt gaaatgatgt ttcaaaagta
    11941 tgaaacattg ggaggagaag ttgagaaaat tcaaattgag cttgaacaat acgaaagaga
    12001 tatagcactt tctaataagc aaataggtgc tatgttaaat gaaaactttg agttttacaa
    12061 tgaacttcaa aaatatattg ttgctggaga aatggcaata gaagaaatgg ataatgaaat
    12121 actacctttc tttaaacaaa aatcagagac tagtggagac caaatggatg ttgtcaatta
    12181 tcaagaacta ttaaaagttt atgatatgtt aaatcaaaga gtctatgatt taaggatagc
    12241 agaaaatata gctatccaaa caatacctat gcttagaggt atgcaacata ataattatgg
    12301 tttaattaga aaaataaata gtgcatttgt cgtaacttta ccagtattta aacaatgttt
    12361 atctcaagct atattactta aaaagcaaga attacaagca aaatctctaa aagcacttga
    12421 tgacaaaact aatgaattat tgcttagaaa tgcacaaaat gtaagtactc aaagtgcaca
    12481 aatagctaga atggctggaa caagttctgt tcaaatagaa acattggaaa aaatgtacaa
    12541 tactattaaa tctggtatag atgaaactat gagaatagaa gaaaacaata gagctttaat
    12601 taaggataat acaaagagat tggaagaatt aaatacgact ataatttata ataagtagta
    12661 ttatattaag ggctaatttg tataaagttg gccctttcta tgtatatgag gaggctagac
    12721 attgaaatat ttcgattata tctgcaaaga tgatttggag agaatttttt tgaaggagcc
    12781 agaagatttt agtgctaaga ctgaaaaaga tgtgttgaaa tatgcactgg gcgctttttt
    12841 atacgttcca gctactcaat ataatatgat ttataagagt attatagggg atgttaaggg
    12901 agttagacca ttagctattt gtttagaaga tgctgttgga gtaaatggag agttagaggc
    12961 tatagaaaat cttagattaa ttttaaaaaa tattagcaat gaaagtataa ctaataaaga
    13021 tggaatacca ctaatttttg taagaataaa agatgtggag caactgttga gaattaaaga
    13081 gattataatt aaaaatagac attctataac aggaatatta attcctaaag caaattcgga
    13141 gttaatagaa aattgtatag aagctttaga ttctatgaat cttcaagata tgtatgttat
    13201 tccgataata gagacaaaag aatttatata taatgaaaaa aaagaactta gttttactaa
    13261 tttgtacaat gctattttaa gacataagtc aagaatatta agcattagag taggcataac
    13321 tgatatatta gggatgtatg gtataaggag agataagaac ttctctatat ataataattt
    13381 gatttgttct tcatttatat tagatataat cacatatctt caaagaccag agttagatat
    13441 acctataagt ggtggagtat cagaattttt tgatatgacg aataaggata taagaaataa
    13501 gtatatagaa gaaatattat tggataaata tcatggatta attggaaaga ccgtaattca
    13561 tccaatgcaa attcaaattg tacaagcgct atctacagta tcatatgaag attttactga
    13621 tgctttggat atactggata gtacagacag taagtatggt gtgagcaagg gtgtattagg
    13681 agagagaatg aatgaaacaa atccacattt tttatgggct aaaaaaacat tgattctatc
    13741 taaaatatat ggtgtattaa ataaaggagt agactatgaa gaattgctta aattttaatt
    13801 gtgagattga cattattgat aatccattga atttagaact aaatgatttt ttagacgtag
    13861 gaataagaaa taatagcaaa agacgttttt tgtttatctc aaagaaactc ggtaaacatt
    13921 tagcatgtaa gccaagtgag atggataatt tgggaaaatt aatggctaca atttataatg
    13981 aaaaaaataa ggaagaatca aatggtactg ttatagcttt tgctgaaact ggtacagctg
    14041 ttgggcatag tttttttgat tacttatgtg gagattatga atttattcat actactagag
    14101 agcagtttga cgagttagaa aatctggaat ttttagagga acattcccat gcaacagacc
    14161 agaatttata ctttggtatg cttaacaact ttaaatttgg agatgagata atattggttg
    14221 atgatgagat taccacagcc aatacatgca tgaatataat taggaaaatt caaagcattt
    14281 atcctaaaaa gaaatacact atatgttcaa tactcaattg ggtaagtgat gaaaatttaa
    14341 gtaaagttac tcgtttagaa agagagctag attgtaagat agattttgta tacttattta
    14401 aaggaaactt taaattttat atagatgaag atattatttc aaattacaac gataattata
    14461 gtattactaa attagagact atttcaagtg ataaagtaaa tttagtagta aatcatattt
    14521 atgttgattt agaagattat attggaaata agaaatatgt aaaatataca ggaagatttg
    14581 gaattaatag aagagaacaa tttagattaa aagaaatcgt taagagagaa agtaaaaaaa
    14641 taactatggc cagtaaagaa tctttaaaaa atgaaaaaga aaagattcta tttttaggta
    14701 ctgaagaatt tatgtatata cctatgctgt ttgcaaaaga aaaagaaaat caatatgata
    14761 tatactatca ttcaacaaca agaagtccaa ttattaatat tgataagaat aattatccta
    14821 ttaaaagtaa atttatgcta aagagttttt ataatataga tattcaaaat tatatttaca
    14881 atatagataa acataatttt tctaagtgtt atttatttgt agagctgaat aaaagtgaaa
    14941 attcttatct agaatttatt gatataatta aaaaaacaag tataaaagaa ttaactatag
    15001 tatgttgtag ctaaagtgtt ttaacaggat aaaatatatc acgattttaa gataggagtt
    15061 gagtcatatg agagatttta gcacgtattc taaagatgat gttatttttt tattaaaaga
    15121 tatatcaaat ttaattgaag aagaaggaaa taaagaaaga gaattaaaaa tacaaaatgg
    15181 tagacattat tcagaaatga taccaataga gtatgaagtt agtgaagatt atctgaattt
    15241 atatcatgag aaactaagag aaaataaaga taaacttgca ttttctatag gagttatgtg
    15301 tgaaaaaata attaaaaaaa atggaaatga tgtagtacta gtttcacttg ctagagcagg
    15361 aacacctatt ggtattttgg caaaaagata tataagaagc aagtataatg taagtttacc
    15421 tcactataca atctctataa taagagataa gggaatagat atgaatgcaa ttgaatatat
    15481 agtaaagaat catccgagct caaaaattca atttttagat ggatggactg gtaaaggaac
    15541 tatatcaaaa gaacttgaaa aagcatgtga tgaacttaat gttaaattta aaaaatattt
    15601 tgactcaaca cttgctgtat tagctgaccc tgctggatat tcaggacttt atggaattag
    15661 agaagatttc ttaataccaa gtgcatgttt aaattcaaca gtttctggtt tagtaagtag
    15721 aactgtacta agagaggatt taattagtaa aaatgacttt catggagcta agttttatag
    15781 acatttaaaa gataaagatg aatctatgaa ctatatcgaa actatagaag aatgttttaa
    15841 aaatcaattt aagaatatat ctgatgaagt tgaaaactgg gaaagtgaca ttataacaag
    15901 agatggatac tttgatgttt taaatataaa agaaaagtat aacataacag atattaactt
    15961 tatcaaacca ggtgtagggg aaacgactag ggttttactt agaagagttc cgtataagat
    16021 tcttgttaaa gacttaaatg ataaatcttt agaccatata ttcatattag ctaaggagaa
    16081 aaatgttgaa gttgaacaaa tggatttaaa agcctataaa tgttgtggaa taataaaaaa
    16141 tatgaaagat atttaggaaa tatattagac aggagaatat tgaatgattg ttttttcaga
    16201 tttagacagg agtatcattt actccaataa atttttaaat gctgatagta aatatgctaa
    16261 tatagaaatt tatagggaaa aagaaatatc ttatatatct ttagatacta taaatttaat
    16321 aaagcaaata caatattatg gtatgtttat acctacaact actagaacag tggagcaatt
    16381 taagcgtata gaatttaata aatatgggat ttattttcct tggagtataa cttcaaatgg
    16441 aggagttata cttaaagata atgaaatatt gaaatcatgg agtgaaaaaa tagataaact
    16501 aaaatctgat tatgagccca ttgaaagtat gattcataaa tttaaagact atttgaatgt
    16561 agatggaata actaatttta aagttgcaga agatacattt ttttatatag ttgttgattt
    16621 atcaagattt aatttggatt caatcaaaga atatacaaat atattggaat caaaaaattg
    16681 gaagttttat gtgagtggca gaaaaatata ttttatacca aaagaaattt caaaagaaaa
    16741 tgctataaaa tacttgacta aagaattagg aatagaatat ttttatgcag ttggagattc
    16801 tattatggac tatggtatgc ttaatatctc aaataaatcc tatgtattga agcatggtga
    16861 tataaataaa aatgaaatag aaaattcatt tatatcaagt tctttcaatg gaatgagtgg
    16921 aactgaagag atactatcta acattttaga cgagaactgc ctacttaata tataatgact
    16981 gatatataaa taataaacta gaaaaatctg aaataaatta tagtaaagtt tatcatacta
    17041 atttatttca gatttttatc aatttatatt taagtaagaa ctcaatatgt taaaatgaag
    17101 gtggagtcat tgcccagact gagatacata cctcatcatc ataattttca tacacatgtg
    17161 gtatagtact gttaaaataa aaactatctc cttcctccaa tagatattcc ttatttccaa
    17221 gtgttatctt cattttacct tttattatat agccacattc ttctccttcg tgtgtcacaa
    17281 attcactgtt tttgtgtgta tgaccatcta gtgtaacaag tataaattct atttttttcc
    17341 cagataaatt aggaacaaga agttcgtaaa attttgtaga atcattagtt actatttttt
    17401 ttcgattatt tttctttact actatatcag agtcttctct tccaatctct tcaaaaaaat
    17461 aacctatatt tatatcaaga gcttttgata ttttccacat tgctacaata gatggaacaa
    17521 ccatattacg ctcaatttga cttattaagc ctgtacttaa atctgaattt tttgctaaag
    17581 tagagatact tatattttta gattttctaa gagatctaat tttgcttcca acatctatat
    17641 tcattagata caaaccccct cagacatgat tataacatat aatttataaa gattaataaa
    17701 ataaaaaaaa agttttacaa tacaagtatt ttttatgcta tattgaattt tctgaaaaga
    17761 tgcattataa tagtattaat attcaatata ttgaatattg ataacgatat tttaatttaa
    17821 tgaaatggag gtaattaaga tgaagagttt tgtaagtcct gataatattt gggtattatg
    17881 ggcagttgta actggatggg cagcatttag tatttatttg gaacaaaagt acaattgggc
    17941 atcaaaagtg tcgggagcaa taatagctct tgtaggagca atgttattat caaatctaaa
    18001 tattatacca gtagagtctg ttgtatatga ccaagtatgg ggatatgttg ttcctttagc
    18061 catagcttta ttgttatatc aatgtaacat taaaaagata tggaaagaaa gtggaagatt
    18121 gctcattata tttcttgtag gttctgtagg aactgtactt ggagctatga ttggattttt
    18181 agcattaaaa aatgtagtac cagatttaaa tattgttgca gctatgatga caggttctta
    18241 tataggtgga aatgtaaact ttgctgctat gtcaggggcg tttgatgcgc caggagaatt
    18301 agtatcagca acagttgtag cagataatct tttaatggca ttatatttct ttgtcttaat
    18361 agctatacca tcaattggat tttttagaaa acattttaaa catccacatg tagatgaaat
    18421 ggaaagtata ggtataactg aaggagaaac agtagcagca aattattggg gaagaaaaga
    18481 aatatcttta aaagatatag caatagccat tggtagcgct tttataattg tcgcagtatc
    18541 tgtagaacta tcaacttggt ttaaagctat aataccatta tcaaatcctt ttttagcaat
    18601 gttaaatact ttatttggaa atcaatatct aataataact actttgacta tgttgtttgc
    18661 cacatttatg cctaatttct ttggtgatat aaaaggagca caggaattgg gtacattttt
    18721 aatatatata ttctttgttg tagtaggtgt tcctgcttca ataacattaa taattcaaaa
    18781 atcaccatta ctacttttat actgcggaat aatggtacta ataaacatgc tagttacatt
    18841 tatagttgca aaaatattta agtttagttt agaagaagct attcttgcat ctaatgcaaa
    18901 tattggtggt cctacaacag cagcagctat ggcaatatca aaaggatggt ctaagctagt
    18961 agggccaata cttatagttg gaacatttgg atacatagtc ggtaattatt ttggtctttt
    19021 agtaggaaat attttgatat aattttacgt gaaaaaaagt tgttttttag aaagattttt
    19081 atttaattgg aggttgttat gattttcgat ggacattcag atacttgggc agatgtaaca
    19141 ataagaaggc ttaacgggga aaaagatgta tttagaagaa tccatcttga taattttaaa
    19201 agagcaaata tagaaggagc tatttttgta atatggatag acccaccata tgataaagag
    19261 cctgaaaaaa gagttaaaca aattataagc tctataaaag atgaaattga agatatgaaa
    19321 gatgttgtaa acatagtaaa aaaatattca gatatagata aaggtataag tgaaaacaaa
    19381 ataaatattt taattggtct tgaaggatta agccatattg gaagaaatat agatttacta
    19441 gattattttt ataaagaagt tggtgcaaga catgcatcat taacttggaa tgaacagaat
    19501 gaacttgcta caggatgttt aggggatgaa aatcgtggtt taactgaaat aggtaaaaaa
    19561 gcagtcaata aaatggaaaa attgggcatg atagtagatg tgtcacattt aaatgaaaaa
    19621 tcattttggg atttaatgtc tgttgcaagt aagccagtta tagcttctca ttctaatgct
    19681 aggagtttat gtgatgctaa aagaaatctt acagataatc aattaaaaga aatttcaaat
    19741 acaggtggat tagttggaat aaatagtttt agaggattta ctaatagtaa tcctaagaag
    19801 caagatttaa tacatttggt tgaccatata gactatatgg taaatcttat aggtatagaa
    19861 catgtatctt ttggttttga ttttagtgat tacttaggga aagagactat aggttctttt
    19921 actggaaatg ctagtgtgcc aagtgtagat ggtcttgaaa gcacacatac agcacagaac
    19981 atagtagtag agcttgaaaa tagaggttat aaaaagaaag atatagagtt aatctctagt
    20041 ggtaattttt ataggctctt taaagatata ctaaaataat ataataaaga acttaaattt
    20101 ataaaatagt atatttatac aaataatatc tacatattta aattggcgtt cataatttat
    20161 taaattaaat tttaatgtta ctagaagttt caattctagt aacatttttt atgttaaaaa
    20221 cagatataga tatatattga caatgataat tattattgat aaactataaa agtgaaaatg
    20281 ataataattt tcattttaat taataaaaga tttttaagga gggagaatga agaaaaggta
    20341 tttagtcata ggaataataa ttttgtctta tttttcttta tttataggag ctgaagatat
    20401 aaatataatg catatatttg ccaaaaatca gcataaactt atgatattta tcatgagtag
    20461 aataccaaga ttaataagta tattgattgc tggtgtagga atgagcatag caggtcttat
    20521 aatgcaacag ataagtaaga ataaatttgt atcacctaca acaggtgcta caatagatgc
    20581 agcacaattt gggatagtaa tatgtatgct tttagtacca actgcctcta tttttacaaa
    20641 gacaataata gcatttgtat tttctcttgt agggactttt acgtttatga aaataatagg
    20701 gaagttacaa tttaaaaata taatctttgt accattagta ggtataatgt ttggaaatat
    20761 aataggttct atgacggatt ttatcgcgta taaatacgat ttgagtcaaa atgttagttc
    20821 ttggatgcaa ggtgactttt ctatgatact taaaggaaat tatgagatat tatatatcac
    20881 aatacccctt ataatattag catatattta tgcaaataaa tttactgttg ttggtatggg
    20941 tatggatttt gcgacaaact taggtcttag ttacaaaaga attgtcaata taggtctgat
    21001 aatagtagca cttgttacag tatgtgtagt cgttacagct ggtaatatcc cttttatagg
    21061 tctaatagtt cccaatatcg tatccttgta tatgggtgat aatataagag caagcatatg
    21121 gtatactggt ttacttggag cgatatttgt acttatatgt gatatttttg gaagaattat
    21181 tatttatcca tatgaaatat ctatagggct tacagttgga gttataggaa gtatactatt
    21241 cctttattta atattaagga ggaatgtaaa tgaagcttag tctcaatcaa aaaatttact
    21301 ttgtaagtat attactattc atatcaatag cactttttat aatttatgga atagacatga
    21361 atcatttaga atatgcatta tcacaaagaa taccaaaaat atttgctatg gtattaggtg
    21421 gaggatgtat agcatttact actgtagtgt ttcaaacaat tacaaacaat caaatattaa
    21481 caccaagtgt actaggttta gattcattgt atgtaatgat tcaaactata atagtattca
    21541 tatttggttc aagcagtagt ctgattataa atgaaaatta taattttatt attaatgtag
    21601 ctatgatgat tggagcttca ttgttattat ataagacgtt atttgaaaaa aataaaaata
    21661 atattttctt tttaatccta gtaggaatga tatttggaac cttatttaaa agtgcaacaa
    21721 catttattca ggtaatgata gaccctaatg aatttttagc tttacaaact agtataatgg
    21781 caagtttaaa caatataaac actaatgtat tgttaatagc atttataata attattgcca
    21841 taataccttt tatatatgat gaaataaagt atttagatgt attgtcgtta ggtaaagaac
    21901 aagcaattaa tttaggtgta gattttgata aagcagttaa aaaaatgata atattaatag
    21961 caattttagt ctcaatatca acagcactta ttggacctat gacattttta ggacttttac
    22021 ttgctaatat aacaagagaa atttttaaaa catataagca tacatacttg atttcgggtt
    22081 ctatgttgat agggatgatt acattgataa taggtcaatt ttttatacaa catgtattta
    22141 agtttgatac aactttaagt gtagtaataa attttatagg aggaatttac tttattcaat
    22201 tactattaaa gggggcaaat agatgataga gataaaaaat atatttaaaa gatataagaa
    22261 taaaaatgtt gtagatgatg tctcttttag tatagaaaag ggaaagataa catcttttat
    22321 aggaccaaat ggagctggaa aaagtacagt actatcaata gttacaagac ttataggagg
    22381 tgatggtgga gaagtaataa tagaaggaaa aagcttgact aattatagca ataaagaatt
    22441 agcaaaaaaa atagctattc ttaaacaatc taacaatata actttaaagc ttacaataag
    22501 agaattagtt ggatttggaa gatttccata tagtgaaggt aatctaacta aagaggatga
    22561 aaattatatt gatgaagcaa tagaatatat gaagttgact gatatacaac ataagtattt
    22621 agatgaattg agtggaggtc aaagacaaag agcttatata gcaatggtaa tagctcaaga
    22681 tacagagtac atattacttg atgaaccact gaacaatttg gatatgaacc attccgtaca
    22741 gatgatgaag gtacttagaa gtctttgtga tgagttagat aagactatag tattagtaat
    22801 gcatgatata aattttgcat catgttattc agataatata gttgcattaa aaaatggaaa
    22861 agttaaaaaa gtaggtcgta cagatgagat agtaaatgaa aaagttttag aagatattta
    22921 tgagatgaat tttaacatta agaatataaa tggaaatcga atctgtattt atttttaaaa
    22981 tattgtatat gaaaataaac ttgctatatg attttttata aagtttttaa attaaaataa
    23041 agattaatag gagagaggaa aatattgata tgaataaaaa agcagcaata gtagcagcag
    23101 tagctattat aggattagtg acagtgtttg cattaggtgg aagtaaaaag aatgaatcaa
    23161 aaacatcaga aaattcaaat aatactatga agataactca taacttggga gaaacagatg
    23221 taaaattaaa tcctaaaaaa gtagtggtat ttgattattc ggctttagat acaatggatg
    23281 cattaggtgt agctgagaat ttagtaggac ttccaaaagc gagtttacca gcatccttag
    23341 aaaaatataa ggatgacaag tatgcagatt taggaggatt aaaagaacca gatttagagg
    23401 gtataaagtc ggcaaatcca gatttaatta taataaatgg aagacaagaa gatttttatg
    23461 agcaattgtc aaaaatagca ccaacaataa gtacaagtaa agatgataag aagtacttag
    23521 aatctgttaa aaataatata gacaaaatag caaaaatatt tggagtagaa gaaaaagcaa
    23581 atcaagaatt tagtaaaatt gaaaagaaaa tagaaacttt gaataaaaaa gtaacagata
    23641 aaaatttaaa tgctttaact ataatggtaa atgaaggtaa tttaagtgta tttggtgaag
    23701 aatcaagatt tagtatatta tacaatagtt ttggatttga aaataaagat aaaaatataa
    23761 aagaatcaag tcatggacaa aatattactt ttgaatatat agctaaacaa aatccagaag
    23821 ttatgttcgt tatagataga ggaatagcta ctggcagtga tgtaaaagaa agctcaactg
    23881 caaaatctgt tttgaacaat gatataataa aatctatgga tgcatataag aatgataata
    23941 taatatattt agattcacca acatggtatg taaatgatgg tggtctaaca tctttaaata
    24001 aaatgataga tgatgcttca aaagcggtaa attaataatc cgatataatc aaaatatatt
    24061 ttttataaaa tgattatcaa ataaactagg agtttttaag aactcctagt ttattttttg
    24121 cataaaaaag atatagttta aacaataata ttatctataa taagataaat ctattcaaaa
    24181 tctaataaaa tatgaagtta tactagacaa aaagaataac tcttaaatat aattaagtta
    24241 tataataata tataattata atgatataat tttaataggt ggtttgtaat taaaaagttt
    24301 ataaattata ttaatagtaa taatctataa gaacttatat attagaaaaa attttgtata
    24361 tatagaggac tctaaagatg aactatgtaa aacaaggttt atatattcta attgtataga
    24421 aaatttattg taaacgcatg tatattatta gaaaaaatag tttgaaggta ttcaataaac
    24481 ataaaaaaca atatagggga taaaggtgtt ttatgaagag atttttgagg agaattatct
    24541 tagttttatt tattttgttg atttttataa gttttatttc tattaaatta attcataatg
    24601 ttggagatta tggaaaattg attaattatg ttgggattgt tcgtggagct agccaacgtc
    24661 taactaaact agagatgaat catcaaccaa atgatgaatt aatagaatat attgatgaaa
    24721 tcctacagga gttgattaca gggcatggag attatggttt agtaatcact gattgtaatg
    24781 aatacaatga ggacttactt ttattagaaa aaaagtggga agatttaaat attgaaatta
    24841 aaaaagtaag aatgaaagaa cagaataacc agttattaag tataagtgaa gagttttttt
    24901 ctcttgcaaa tgatacagtg tttaaaatag aaaacttttc taaagaaaaa agtaattact
    24961 taatgacttt aataataatt atatctatta taggtatatt agcatgtatc atattgattt
    25021 tacaatatag taaaaaaatg gttagactgg aaaaattaaa tgtagattta aaaaatattg
    25081 catataaaga tgaactaaca ggagtaaata ctatagaaaa atttaaattg gatgcaaatc
    25141 aaaatatttg tatacataag gataagaaat ttgctgtatt ctatattgat tttgaaaact
    25201 ttaaatacat taatgatata tttggatatg attatggtga catgatactg aaaagatatg
    25261 ctaatcttat gatgaatgac atagggaaat atgaaatatt tgcaagagaa attgcagata
    25321 gatttgttgc gttaagatgc tatgtagata aggaagattt agtggtaaga caacgagatg
    25381 tagacaatga actaattaat ataacaaatg aaattaaaaa taaacatagt attactgttg
    25441 ttagtggaat ttgttgtatt gaagatgtaa atgaaaaatt aagtatagat ggtttaataa
    25501 atagagcaaa ttttgcacaa aaaactgtta agaataaacc aggtactaat tatgcttttt
    25561 ataatgacag tattcgtaaa aaaatgattg aagaaaatac tatcaagagt agaatacatg
    25621 aagctattga aaaaagagaa tttatagttt atttacagcc taaagttaat ttacatagtc
    25681 aaaaaataaa ttgtgcagaa gctttagttc gttggcttac tccggataaa ggtattatat
    25741 cgccagcaat atttattcca gtacttgaga agaatttttt tattgcctta gtagataagt
    25801 atgtttttga ggaggtttgt aaatggatta gaaagaggtt agatgaaaat aaaccttttg
    25861 ttcagatatc agttaatgtt tcaagaatac aattttataa cactaaattt gtagaaactt
    25921 attccaatat acaaaataaa tacaggatac ctaaaaatac tatagaaatt gaatttacag
    25981 agagtgttgc ttttgagaat caaaaacatc ttttggaaat tatacatgat ttgcatgaaa
    26041 atggatttac ttgttcttta gatgattttg gaaaaggtta ttcgtcttta agtgttttaa
    26101 aagatttacc atttgatgtt ttaaagcttg attctatgtt tttcaaggct agtttagata
    26161 aagataaaga gaaaatagta ataaaaaata ttgtacatat gttaaaagaa cttaatatca
    26221 caactgttgc tgagggcatt gaatgcaagg aacaagttga atttcttagg gatattgggt
    26281 gtgatttagt tcagggattt gtattttata aaccaatgcc aatattagaa tttgaaaaaa
    26341 tattggataa agagtttgtt tataatagct aaaatgtact ttataaaata tgaactaatt
    26401 aagtaaaatt attttgtact gaataaattt ttactttatt tacagaataa tgattattta
    26461 cagaaaagcg cgaaaagtgt attcctttaa gtgtgggatg gatagcacaa atagaggaga
    26521 aaaaatattg gccatataag aatgcataat aatataaata tttgaaaggt cagcattata
    26581 taaaaattaa aaagaaaata aataattttt ctataaaaaa gagactatga gaaaatttac
    26641 tcatagtctc ctaaataatg tatttatttt cttcctgcaa cccattttaa tccccaatga
    26701 aattcagtat ccatttctct atgacctttg aagtatttaa ctactttttc aacactgaat
    26761 gtctcatcat ttacattttc tatcaatgct attgaacaca tattatagcc atttttatgt
    26821 tcatcaagtt tgacaactaa gtctgaatct tgtttttgtt tgattgttac aattccatca
    26881 gcttcagacc agttagctac accttcgtat ataaaagcat aaataagtat tctttttata
    26941 tcttttattt tattaccatt tattcttaaa ttttctcctt gtgtattact tcctgttctg
    27001 tcatctccat ctaattgagc aaaaggtgga ttgtctaaac taccaaaggc atttcctaat
    27061 gcttgaacag ctccttttac accatttttc atctcaaata ggcaacccaa atctaaatct
    27121 atattactgc ttcttaaaga gccaaaaaaa cccttttttt gtactttttg attccaattt
    27181 aaattaacta agatttcacc taaatcgcta ttttcctttt ttgtaaggtt tattttttgt
    27241 ccctttttta attctatagc catagtaatc ttcctccaca aacatagatt tatttaaatg
    27301 gtagcactta ataagtcaat attcaacaag attagaataa taatattaaa attatactaa
    27361 atatactaaa aagtaggaat cacaatacct ttgtattttt cttcaattaa gcttcttgct
    27421 ttatctgatg taagaacatc ttgtagaact ttaatctttt cactgtcttt atcttcagtt
    27481 ctaaatgcta aaagatttgc atactcgtca tttataggag ctgtataaat tccgtttttc
    27541 ttggcatcaa gaccagcagg tacagcataa gtagtatcta taaatgcagc agtcacatct
    27601 ggaagagaag atggaatttg agcaatatct aactctttga attgtattcc ctttggattt
    27661 tctattatgt ccttaggact aactaatcca tcccctttag gtaacgttaa aagtccaata
    27721 ctttcaaggt atctaaggtt cttagaacaa gaagatgggt tattgcttat tgcaattgta
    27781 tctccttttt taaattcatc aacagatttt atcttataag agtaaagtat tgctgggcat
    27841 acatatagtt ttttaccagc cattattttg taacctttgg ccttaacagc ttcttttaga
    27901 taaggttcat gttgaaatag atttgcatca atttcaccat tatttaaagc ttcgtttgga
    27961 agtatgtaat catcaaagtt tttaacttct aaagtatatc ctttttcttt aataagtggt
    28021 tttaattctt ctaataactc tcctcctgga actaaagtag caccaacaac aattttttta
    28081 tcatctttag ctttagaaca tccaaccaca gctaaagtta atactagaca taataacaaa
    28141 cataataatt ttttgaattt catataaatt ccctcctgaa tataattgat tagttaaaaa
    28201 taaaatacca ttctttatca cactgcaaaa taaaaataag cctgagttta aactcaggct
    28261 ttaaaagcta atttagactc atctttcagt ataatactgc aggatttagc accaatgtat
    28321 ataaaaatat actggttgct gggtttcata gggccagtcc cttcaccact ctggataaga
    28381 agtatcaatt tttaattatg ttataaatat tatcatgatt ttttacgtct gtaaacataa
    28441 ttttataaat attttaaaat ctttaatgta ttttatttaa cacctaaaat tccagaaact
    28501 agaatatcag tatcagcacc taagaaatag tcatttattt caatagaatc cagagtattt
    28561 ctcaaagcat tttcttcatg ccttatacca ataagtttat tttctacaaa tgcaacatca
    28621 cattttccaa aaaaatctcc aaaaaatttt atactagtta ttatgccttt atcaacattt
    28681 aaattaaact caacatttcc accagaatat tttaattcat ttgaaagagt atattttggt
    28741 gaattaccaa aattccaatc ccaagtttcg tattttgatt tagtaagctt ttctatttgt
    28801 tttatatcat gctcactcaa acaataatta gtattatcag tatttgtttt agaaagataa
    28861 tccattatag catctttaaa ttctaatatg tccatttttg aatgtaaatg ttcacttata
    28921 ttggttacac gagattttac agattttatt ccttttcctt caaattttat aggtttaacc
    28981 tttaatgctt ttgagaggtc atttatttca gatgaaaata aaagagtacc atgatgcatt
    29041 actttgtttt tgtagttgta ttgagcattt ccagaaaatt tcttgccatc tataagaagg
    29101 tcatttcttc cagaaaattc ggcattgaca tctagtgttt taagtaaatc tattatgggc
    29161 tgagtgaatc ttctgaaatc actaaaatta ttattgttac aagctataaa tgtaaaattt
    29221 atatttccca aatcatgaaa tacagctcca ccaccagact gtctcctaac gacaggtata
    29281 gaatattctt ttatatattc taaatttatt tcagaaagtg tgttttggtt ttttccaaca
    29341 attatagaag gttcattcct ccataaaata aataagtctt catcaaaatt ttttagaaga
    29401 tattcttcca ttgctaaatt aaaataaggg tttgtttttt cattataaat taataacatt
    29461 aaagtagttc ctccatagaa ttgataaaat ttttattatg aatacaatta attttataat
    29521 tcgacaataa tataaaaact cctttaaatt agaaatttta aaaactacct tgcaaagttt
    29581 aaataaataa tatatactca aaatatgttt aataaaagtg aatagaaggg tagaggcgca
    29641 ataatctatc agtactaata aggagttaag cacagagatt tattaggaaa ggagatattg
    29701 ccgaagtttt ataatcgatg ctttaagatt atattgctgg gggtacatag aaaatatgta
    29761 caactgtcac aggtttattt gtggtgagct atcatttaag gaattatatt atatttattt
    29821 ttactattgt tgatatattg taatgtttaa gccttgagtg tttaccactc aaggcttttt
    29881 tagttttatt gtaacataat accctgtaca gttcacaaaa ttaaaaggag agggagattt
    29941 atatgaggaa caaaaaaatt aatattattt ttctgacgac aatcatgttc ataatgtcaa
    30001 cagtaatggt ttttgcagaa gaagatatag acactattgc actagccaat gcagaaaaat
    30061 ttgggatttt aactttaata ccaccattag ttgctataat acttgcattt ataactaaaa
    30121 acgtaataat ttctttactt ataggtattc tttctggtag ttttataatt aaagctagtg
    30181 gtattaatgt ttttgcgaca tttatacagg catttttaga tttagtagac agagctttag
    30241 tatctttagc agacccttgg aatgcaggga taatactaca ggttttggca attggaggag
    30301 taataaatct tgttgctaaa atgggaggag ctaaagctat agctgaagca cttgctaaaa
    30361 gagcaaagtc agcaaaaggg acacagctta taacatggtt tttggggctt ttagtattct
    30421 ttgatgatta tgccaattca ctaatagtag gtcctatgat gagacctgtt gcagataaaa
    30481 tgaaaatatc gagagaaaag ctagcattta taatagatgc cacagcagca ccagttgctg
    30541 gtttagctat aatatctaca tggataggtc ttgaggttgg tttaatacat gatgcttttg
    30601 aaagtataag tatagatgta gatgcatttg gtatattttt aaatacaata ccatttagat
    30661 tttacaatat attaatatta gctttcattg taatatcagc attattatta aaagaatttg
    30721 gtccaatgag aaaagctgag ataaaatcta gaagtagaaa aattagtata gaccttgatg
    30781 aaggcgtaga agagttggat gatttagctc caaaaaatgg agtaaaattg agtgtatgga
    30841 atgctataat cccaatagga acattgataa tagttgcatt agcatcattt tattatagtg
    30901 gatatacatc tataatggga ggagacgata aggctctgat acaactattt acaaattctc
    30961 catattcttt tgaagcaata aaagaagcat ttagtgcatc tgatgcatct agagcattat
    31021 tccagtctgc acttgttgca agtttagttg ctattataat ggctgtagta aaaaagattt
    31081 ttacaatatc agaagcaatt gatgtttgga tagatggaat gaaaagttta gtaatcactg
    31141 gtgtaatatt aatacttgca tggtcattaa gttcagtaat aaaagagtta ggtacagcta
    31201 aatttttaat acacctatta tcaggttcac taccaccatt cttattacca agtttaatat
    31261 ttggtttagg agcaataata tcttttgcta ctggaacagc ttatggaaca atgggtatac
    31321 ttatgccact tgcaattcca ttagcatact cattaaatcc tgatatgtct tatgtaatag
    31381 taagtactag tgcagtttta acaggtgcaa tatttggaga ccattgttct ccaatttcag
    31441 atacaacaat actttcttca atgggagctg gctgtaatca tatagaccat gttaacactc
    31501 aaatgccata tgctatattt acagcagtaa tcactattgt atttgggtat ataccagctg
    31561 gacttggatt gccaatatat atagtattac cagtggcaat agctgctata tttgtaggta
    31621 ttcaaataat tggtaagaaa gttgatgaag cggaaataga acttgtagaa taaagatata
    31681 aataagtttc accttttatt atcactattt tgttagtttt tagataattt taaaaagtta
    31741 ttgaaaataa tggcgaaata tagtaaaata aaagagtgat aagcggatgt ggcggaattg
    31801 gcagacgcac tagacttagg atctagcgcc attggcgtgg gggttcgact cccttcatcc
    31861 gcactttaca gtacttaatt gtactgaaaa aaactggggt tgctggcttt cggagtgggc
    31921 tatcccgttt ttattttttt gtatatataa tagattggca ctttagtata aggtgctttt
    31981 tttataggca aaaacagtac atttatttct gttttattat cattcatcta ttagaatata
    32041 ctttagttaa gaatgtgtta ataagcagtg ttcacattct tgataaaatg tggaataata
    32101 tgtattttta ctaagacgga aatgaaataa ttaaaccatt aaataatatt ataagatgat
    32161 gaataagtag ataaatcaaa ttttgtagga ggatattatg gaaaaatata tatggttgtt
    32221 tccattactt tttatttttc atgatatgga agagataata ggttttggaa tatggcttaa
    32281 aaaaaataaa tcaatgcttg ataagaagta tccatttatc agtaaagttt atgaaaatta
    32341 tagtactgaa ggcatggcat ttgctgtgtt tgaagaattt attttatgca ttattttctg
    32401 tatacttaca gttataacag agaatcagta tgtatatcta ctatggttag gtagttttat
    32461 agcatatacc ttacatttgg taattcatat agggcagtca atcataataa gaaaatatat
    32521 accttcactt attaccagta tcatatgctt accaataagc atttggtgta taagtaagag
    32581 tatttatata gttgattgtg aaatgagtac aacaattctg tacagtataa ttggcattat
    32641 aattgtagca ttgaatttaa agtttgcaca gtcgctgatt ggaaaattta caaagtggat
    32701 gtcaaacata taaattttag tttattggac agttcaagga atcagaaatt ggaattttat
    32761 agtattaata ttttatggta ttaatataat gtataaaatt ttatagcaat gtatttcata
    32821 agtataaagt gactagaatt ttaagaaata tacaaattct ataaaaacta aataatttca
    32881 agtatatttt aaaaatctta tttttcacaa gtttaaaatt gtaaacgatt tcatcaagtc
    32941 tatgaatata cttttaacat gttatagtaa atctcaatat aaatttacat ttggttcttt
    33001 gtgtgttatt tt
//
LOCUS       DAEPID010000042        31838 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.042, whole genome shotgun sequence.
ACCESSION   DAEPID010000042 DAEPID010000000
VERSION     DAEPID010000042.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 31838)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 31838)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..31838
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.042"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            complement(<1..302)
                     /locus_tag="KR257_002207"
     CDS             complement(<1..302)
                     /locus_tag="KR257_002207"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428307.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sensor histidine kinase"
                     /protein_id="HBH0030891.1"
                     /translation="MNREKLVAFIRYLSLFILVVSYLKNVENTLYPVITMIILFLIII
                     NNQVRFFSLSNENKFILISYFLELILIFILCNYTKTFNSIYFVPLILDISFLIKEK"
     gene            486..830
                     /locus_tag="KR257_002208"
     CDS             486..830
                     /locus_tag="KR257_002208"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438259.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YraN family protein"
                     /protein_id="HBH0030892.1"
                     /translation="MNNKEKGDFGEKVAVNYLLSKGAKILEKNYRLKIGEIDIIAKME
                     DEIIFVEVKSRSNIKFGYPCESVSFKKRKKIIGVANYYIIKNNLNNTPVRFDVIEVYL
                     LEKRINHIMNAF"
     gene            861..2462
                     /locus_tag="KR257_002209"
     CDS             861..2462
                     /locus_tag="KR257_002209"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729548.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YifB family Mg chelatase-like AAA ATPase"
                     /protein_id="HBH0030893.1"
                     /translation="MLSIINSSNLVGIDSFLVKVEVDVSNGIPSFNIVGLPGKEIKEA
                     RERVKSAILNSGYKFPSTRIVVNLSPADIKKEGAFLDLSISIGLLRELIKKDENYIRE
                     SMFIGELSLDGKIRKVRGILPIIMGAKTQNIKRIFIPIENIKESLFVDEIDIIPIKSL
                     KECVDFLNEEIKVDKVRIMSFLDDKSRKENEELEKDNSYIDCKYTKINNEESKYDEDF
                     KDVKGNYFVKRSAEIAAAGNHNMFMIGPPGSGKTMIAKRVRTILPDISVEEMIEVSKV
                     YSILGMINETKGIIDKRPFRAPHHTTTKQSLIGGGMDARPGEIALAHRGILFLDEIAE
                     FDRKILETLRQPIEDGYVNISRVKYSAKYPCRVLLVAAMNPCPCGYYMSETECRCRSN
                     EIDRYINKISGPLLDRFDIFVEVNSIKYSDFNSLKQEESSQKIKRRVENARKIQINRF
                     KKDNIKNNSEIKAYNLFKYCKLEKEASKTAEMIFNKYNLSSRSYTKLLKMARTIADLE
                     ERDLINSQCIIEAFSFRKAYYSYFK"
     gene            2481..3581
                     /gene="dprA"
                     /locus_tag="KR257_002210"
     CDS             2481..3581
                     /gene="dprA"
                     /locus_tag="KR257_002210"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438264.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA-protecting protein DprA"
                     /protein_id="HBH0030894.1"
                     /translation="MEKRDTYLWLKSIGGITTKTIEIIENEIVNIEDIFDFSEKEIYN
                     LKNISLNIRKNIVKYRGHAYLENIKELLYKKAIKYICKYDKEYPENLKNIYNAPKLLF
                     YKGDIGLVNNNFNIAIVGSRKPTAYGINCAKTISCQLSQYGVNIVSGLAIGIDAYSHI
                     GCMSGKSKTIAVLGSGVDNPLPKQNLHLSNKILENGGLLLSEYNINSTVAPYHFSNRN
                     RIISGLSDGVVVVEAAIKSGALITVDFALEHGKNVFAIPGNINSQMSRGCHKIIKEGA
                     KLIENIDDILNEYNIFNIIDKKINQKYDNISLNAKSKQIIEAIKREGNLHIDSICDYT
                     GIEIKYVNSIINELVLNELVVEMNNKTYSLNV"
     gene            3614..5701
                     /gene="topA"
                     /locus_tag="KR257_002211"
     CDS             3614..5701
                     /gene="topA"
                     /locus_tag="KR257_002211"
                     /EC_number="5.6.2.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892959.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type I DNA topoisomerase"
                     /protein_id="HBH0030895.1"
                     /translation="MAKTLVIVESPAKAKTIEKFLGKSHYTVKASVGHVRDLPKSKLG
                     VDIENNFEPQYINIRGKGDVIKELKKEAKKSKQVYLATDPDREGEAISWHLAHILNLD
                     ESEDCRIEFNEITKDAIKKAIKHPRNIDINLVDAQQARRVLDRLLGYQISPILWQKVR
                     KGLSAGRVQSVTTKLICDREKEIKAFIPKEYWTIDVEAKTVKDKDITLKFYGKNDEKI
                     ELENEEAVNEILKEMEGKDLKVEKIESKSRRKSAPKPFTTSMLQQEGANKLFFTTKKT
                     MMIAQELYEGIDIEGEGTVGLISYIRTDSKRISDEAKEKAKGYIVNNLGENYYKNTGD
                     KKEKKDTKKVQDAHEAIRPTSVDRTPESIKASLSKDQYKLYNLIWRRFVASQMEDSVF
                     DILNVECKIGDIVFKATGSKMKFDGYTKVYNFSEREDKILPSIEKGDILNIENILPDQ
                     HFTQPPARYTEASLVKTLEELGIGRPSTYAPTIATILNREYVEKQGTSLCPTELGIIV
                     TDILENNFHKFIDVDFTADMESKLDVIEEGNTDWKKIVSESYAPLKEAIEEALENIEK
                     VNMDEETDEICENCGSNMVIKYGRFGKFMACKNYPDCKTTRPIMNKIGVKCPKCEEGD
                     IILRKSKRGKAFYGCSNYPNCDFVAWNKPTGEFCEKCGSYMVEKVTKSETKTVCSNKE
                     CNKETKEHNDGKE"
     gene            5866..6651
                     /gene="codY"
                     /locus_tag="KR257_002212"
     CDS             5866..6651
                     /gene="codY"
                     /locus_tag="KR257_002212"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438268.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GTP-sensing pleiotropic transcriptional
                     regulator CodY"
                     /protein_id="HBH0030896.1"
                     /translation="MASEVLQKTRKINKTLQTSGGSSVSFDLLAGALGDVLSSNVYVV
                     SAKGKVLGLHLNDVQDSSVIEDEYTKQKKFSDEYTQNVLKIDETLENLNGEKILEIFP
                     EEHGRLQKYTTVVPILGSGQRLGTLVLSRYSNSFNDDDLVIAEYSATVVGLEILRAIG
                     EELEEEMRKKAVVQMAIGTLSYSELEAVEHIFAELDGKEGLLVASKIADRVGITRSVI
                     VNALRKFESAGVIESRSLGMKGTHIRILNDKLTDELKKLKNNQ"
     gene            6758..8023
                     /locus_tag="KR257_002213"
     CDS             6758..8023
                     /locus_tag="KR257_002213"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861165.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="replication-associated recombination protein A"
                     /protein_id="HBH0030897.1"
                     /translation="MPLADKIRPKTMNDVIGQSHIIGNGKILSKILQSNFLPNMIFFG
                     PPGVGKTTVAEIIAERSNKSFYKINATNSSLEDIKKVISELGSINNVNGVLLYIDEIQ
                     SFNKKQQQSILEFMENGSITLIASTTENPYHYVYKALLSRSTVFEFKPLEKLDVEKGL
                     KRAVEVLNEDSYMDIECNNNAIEDIAILSDGDMRRALNILEVVVYSTKPNKDNITYID
                     SDVIRASTFNKIINYDKNGDSHYDILSAFQKSIRGSDPQASIHYLARLIKGGDLISIC
                     RRLLVIASEDIGLAYPNAIVIVKACVDSAMQLGFPEAKIPLAEATILLATSPKSNSAC
                     IAIMKAMDELDKEFVKDIPNSIKDSHYSGSKEIGRGCGYKYPHNFKNHYVKQQYLPDS
                     IKDSIYYIPQENKTEKNIKKYLEYLNSDF"
     gene            8054..8824
                     /locus_tag="KR257_002214"
     CDS             8054..8824
                     /locus_tag="KR257_002214"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419406.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HBH0030898.1"
                     /translation="MIIKLNSTYHSRVMKYLKKEPEYNLFIIGDIERYGYGNNFLNIW
                     ADVGEHGEIKAILLKYFEFMIFYSDGEYDVEGFYNLLRNTNYEEISGKICAVDALAKR
                     LGLNNLKVVDFCKLQTKKFLIDNNCNAKVKRIRLGNLKKTVKLYDLIDEFHSTTLENL
                     KNGLRTGRGYCIEINKQVVSMAKSTSENRTHAMIIGVGTHPKYRAKGLATKCLIKLCS
                     ELLRENKIPCLFYDNEEAGKIYKKLGFENIGKWGIYSK"
     gene            8933..9379
                     /locus_tag="KR257_002215"
     CDS             8933..9379
                     /locus_tag="KR257_002215"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419409.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Rrf2 family transcriptional regulator"
                     /protein_id="HBH0030899.1"
                     /translation="MKLSTKGRYGLKAMFELALNQDNGPVSLKFIAKKQKISDQYLEQ
                     IFSSLKKSGLVKSVRGAQGGYLLSKNAEDITVGDILVVLEGPVALSDCVLDEDVCENS
                     NMCVTKIVWEKMKKGIEDVIDSITLKDMINDYNKNKLENDITNIKK"
     gene            9397..10590
                     /gene="nifS"
                     /locus_tag="KR257_002216"
     CDS             9397..10590
                     /gene="nifS"
                     /locus_tag="KR257_002216"
                     /EC_number="2.8.1.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861166.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cysteine desulfurase NifS"
                     /protein_id="HBH0030900.1"
                     /translation="MEKRRLYMDYSATTPIKKEVLDAMMPYLTDYFGNASSFHTFGRE
                     AKDALDKAREQVAALINAEPSEIYFTAGGSESDNWTLEGVAYANKNKGNHIITSKIEH
                     HAILHTCEYLAKHHGFEITYLDVDSEGKVDLKQLEDSIKDTTILISIMFANNEIGTIQ
                     PIKEISEIAKKHKILFHTDAVQATGNIPVDVKELGIDLMSMSSHKIYGPKGVGALYIR
                     KGVRLHNFVHGGAQEKSKRAGTENIPAIVGYGKAAELAKENMQNHVETLTRLRNKLID
                     GVLERIPYTRVNGSLDNRLPGNANFAFQFIEGEGILLLLDMLGIAGSSGSACTSGSLD
                     PSHVLLAIGLPHEIAHGSLRLTVGDFTTDDDIDYILENLPKVIERLRSMSPLYDDAKK
                     QGLVK"
     gene            10644..11084
                     /gene="nifU"
                     /locus_tag="KR257_002217"
     CDS             10644..11084
                     /gene="nifU"
                     /locus_tag="KR257_002217"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902397.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Fe-S cluster assembly scaffold protein NifU"
                     /protein_id="HBH0030901.1"
                     /translation="MQYSDKVMEHFMNPRNMGEIDNASGVGEVGNPTCGDIMKIFLDI
                     DGDVIKDVKFKTFGCGSAIASSSMATEMIKGKTIKDALELTNKAVAEALDGLPPVKMH
                     CSVLAEQAVKAALIDYAQKNNIHIPELDGYVIDDAHDHDVEEEE"
     gene            11373..12452
                     /gene="mnmA"
                     /locus_tag="KR257_002218"
     CDS             11373..12452
                     /gene="mnmA"
                     /locus_tag="KR257_002218"
                     /EC_number="2.8.1.13"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438277.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA 2-thiouridine(34) synthase MnmA"
                     /protein_id="HBH0030902.1"
                     /translation="MNKKVMIGMSGGVDSSVAAYLLKQQGYDVIGVTMKLWQDDDVVE
                     IEGGCCSLSAVEDARRVANKIGIPFYVLNFREVFKEKVIDYFIDEYLEGKTPNPCIAC
                     NKHIKFDDFYKKARQIGCDYVATGHYAKIEKDESTGRYLLKKSVTDKKDQTYALYNLT
                     QEQLEHTLLPIGDYEKDRVREIAKEMGMAVHNKPDSQEICFVKDNDYANYVKKHSKKR
                     IEEGFFVDTKGNILGKHKGILYYTIGQRKGLGITFGKPMFVIDINPINNTIVLGDNED
                     LFKKELIAKDVNFISIDTLEEPLRVQAKIRYSAKPSPATIHRVGEDTIKIVFDEAQRA
                     ITKGQSVVMYDGDIVVGGGIIEKSL"
     misc_binding    12595..12833
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00230"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="T-box leader; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /bound_moiety="tRNA"
                     /db_xref="RFAM:RF00230"
     gene            12901..15540
                     /gene="alaS"
                     /locus_tag="KR257_002219"
     CDS             12901..15540
                     /gene="alaS"
                     /locus_tag="KR257_002219"
                     /EC_number="6.1.1.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428286.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alanine--tRNA ligase"
                     /protein_id="HBH0030903.1"
                     /translation="MEKMGLNEIRSKFLEFFESKGHYVANSYSLVPNNDKSLLLINSG
                     MAPLKNYFSGVEVPPSVRMCTSQKCIRTGDIENVGITARHATFFEMMGNFSFGDYFKR
                     ESIKWGWEFVTEWLNIPEDKIWVTVYEEDDDSYDIWAKEMNFPEERMVRLGKDDNFWE
                     IGTGPCGPCSEIYFDRGEEYGCDNPDCKPGCDCDRYLEFWNHVFTQFDRDEEGNYSLL
                     ENKNIDTGMGLERMGCIMQGVDTIFEVDTIKSILEAVEKLTGVKYGENPKNDISIRII
                     TDHIRAVTFLVSDGVLPSNEGRGYVLRRLLRRAARHGKLLGVKELFLQKLIDEVIKVN
                     DKAYPVLVEKESYIKKVVGIEEEKFNETIDQGTEILNSYIEVLKNEGKTVLSGQEAFK
                     LYDTYGFPIDLTKEILEEEHLSVDEEAFNEEMEKQKERARNARGNMDGESWKEDPLSK
                     LESTVDSTFNGYSEIYGEGTIEAIVKDDELVQSAEEGDKVSIVLDNTTFYPEGGGQVG
                     DCGLITNENLVLEVLNTKKGANNSIKHIGIIKSGRISNGDKVKTLVDRETRMSAARNH
                     SATHLLHKALREVLGEHVNQAGSLVTPERLRFDITHFEAISNEELKVIEEKVNNVILS
                     SLDIKCDIMNIKEAKEKGATALFGEKYGDEVRVVSMGDYSTELCGGTHLTNTSQVGMF
                     KILSEGGVAAGVRRIEAITGKAVYEYLKERDGIISEVCVNLKSKEDNLIQRISSLLEE
                     NKNLSKELHDMKAKMSLQSVDSIFDSKVEVNGVNLITNKFEGMDMDTLRETADNLRDK
                     LGSGVVVLANVVDDKVNFVVTATKDVLDKGIHSGNIVREVAKIAGGKGGGRPNMAQAG
                     ASDVSKVDQALSYASEVIKTQVK"
     gene            15565..15822
                     /locus_tag="KR257_002220"
     CDS             15565..15822
                     /locus_tag="KR257_002220"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419418.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IreB family regulatory phosphoprotein"
                     /protein_id="HBH0030904.1"
                     /translation="MEKDLDYTMKFEGIPEDRMSVGDTIDFVYKALVEKGYNPINQII
                     GYLLSGDSSYITSHKNARAIIKKFERDEILEEVITHYLNRK"
     gene            15832..18003
                     /locus_tag="KR257_002221"
     CDS             15832..18003
                     /locus_tag="KR257_002221"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428282.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0030905.1"
                     /translation="MRKKIMSLFAIVIMIFVSTASYGFAEEKGKVIFIDMNRTNLGSM
                     MNIPILKNEIEKRGYVALMNIRGDQGTDDRRSCASMGAGTRASVTTEDYINFQKVDQD
                     TAKAFEVATGQKAKEINDLGINRSINENLEYGEYGANLGSLGKTLSENGLKTSVIGNA
                     DIIENNQLVKNRNLCLVAMDQYGRIDSGNIDNINKKDSKMPFGISTDYDKLLDETKKS
                     YKNSDAIFVELGDTYRLDMYRLNLNDNTYDTMKKNIVKNINKYLEQVFSMVGENDTVY
                     IASAFPSDLDYKNKRRLSPIIKFSGEGKGLLESATTRKAGIVANLDVGVDILGTFGLE
                     NKEMVGRSYTLVNKEDNISYLKSLYERIVSISSIRSTIINGFVGVISASWVIAMFAIF
                     FRNYMPHKERVFKVLKEFIKLGIIMPLSFMLAPLMNFKTPISISLGIFATTLILYLLG
                     RKLFKDNDIKHMGFFATLTILVIVIDSVFGTYLMQNNIMSYDAVIGARYYGVGNEYEG
                     VTIASAVFGLAVLLHYKKVSKLLVVIFSLIILITSAYPSMGANVGGAISECVAYLLFI
                     MLIYDIKIDFKKAVLLAVSAVVVVFAFAALDILSGSESHLGMFVQRIFLNGPGEILQT
                     FGRKIQMNMQLAQTSVWVNILLVGIGVIAVLIFKPSRHFRKIMNNFPILFKGFIASMV
                     GCIITLLVNDSGIVAASTASIYILIPLIIISINMIIFEKNN"
     gene            18209..18634
                     /gene="ruvX"
                     /locus_tag="KR257_002222"
     CDS             18209..18634
                     /gene="ruvX"
                     /locus_tag="KR257_002222"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428279.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Holliday junction resolvase RuvX"
                     /protein_id="HBH0030906.1"
                     /translation="MLDGRIMGLDVGDKTIGVAVSDLMGLTAQGVKTIKRVGKKKDIE
                     ELKAIIKEKQVNKIVSGLPKNMNGTLGPQGEKVIKFCELVKAETGIDVEFWDERLSTV
                     AAERSLLEADVSRQKRKKVIDMLAAVIILQGYLDFKINS"
     gene            18712..18999
                     /locus_tag="KR257_002223"
     CDS             18712..18999
                     /locus_tag="KR257_002223"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889069.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1292 domain-containing protein"
                     /protein_id="HBH0030907.1"
                     /translation="MEENIINLIDENGVESQFEIILTLEAEGKEYAILMPLDDEEAEE
                     ALIFRIDEDEEGEILIPLESDEEYETVVAVYTAIMEEEGLNYDEDESNGLN"
     gene            19281..19739
                     /locus_tag="KR257_002224"
     CDS             19281..19739
                     /locus_tag="KR257_002224"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419428.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcriptional repressor"
                     /protein_id="HBH0030908.1"
                     /translation="MANTMDLLKDKLKETGFKITPQRRAIVEILLKHDHSHLSSEEIY
                     DLVRVDCPEIGLATVYRTMQLLDEIGLISKLNLDDGCIRYEISLHKEDCHNHHHLICK
                     NCGKIMEAKEDLLDNIEKEIQSLYKFKILDHDVKFYGLCDECNGVSDSEE"
     gene            complement(19856..20593)
                     /locus_tag="KR257_002225"
     CDS             complement(19856..20593)
                     /locus_tag="KR257_002225"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428273.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="metal-dependent hydrolase"
                     /protein_id="HBH0030909.1"
                     /translation="MRGKTHCAIGILTAIQTSLIFKIPISLVDILVSATFAVLPDLDK
                     SNSMVSNFILKNNVSKYIYRIFIYAVNIIIFFISININDNFYLSAIITFVAIIIIEAK
                     LTHTFLRKVFLSLIFILLAICLYIIEVEIYFTIFCLMLSIFPWLKHRSFSHSIFATII
                     VYFLLKQIELITNINNLSFYGTIGYASHMFLGDLFTKQGIPIFYPLSEKKISLGFLTV
                     GGPFSNFIEKSFIFVLIGLIIFSILKL"
     gene            20810..22486
                     /locus_tag="KR257_002226"
     CDS             20810..22486
                     /locus_tag="KR257_002226"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861169.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribonuclease J"
                     /protein_id="HBH0030910.1"
                     /translation="MQLFKKNTNKIKVMALGGLNEVGKNMTVVEYKDEIIVIDAGLSF
                     PEDEMLGVDIVIPDITYLVKNRDKIKGIFITHGHEDHIGALPYILKKINVPVYGARLS
                     IGLIQVKLKEHKMNNVKLNVIGPRQVIKLDNMEVEFLKNNHSIPDAYSIAIHTDQGII
                     YHTGDFKIDLTPIDGDVMDMHRICELSKKGVLLMLADSTNAEKPGFTMSEKTVGVGLD
                     ELFAKGNGRRIIVATFASNIHRLQQIINTAEKFNRKVAISGRSMVNVVGVAKELGYLD
                     ISDDMLIDLNDICKYEDSELVIITTGSQGEPMSALARMAFSEHKKVEIKSGDLVIISA
                     HPIPGNEKLISRVINFLFEKGAEVVYSDIADIHVSGHACQEELKLIHALVRPKFFMPA
                     HGEYRMLKRHAEIAEQLGMDKENIFVMQTGDVLELDKNSAKVANRIQTGNILVDGLGV
                     GDVGNIVLRDRKHLSEDGLMIVVVTISKDEGKVLAGPDIISRGFVYVRESEDLMDGAK
                     DIIKNVLNECEEKNIKEWAYLKNNIKENLKEYLYQKTKRNPMILPIIMEV"
     gene            22694..22894
                     /locus_tag="KR257_002227"
     CDS             22694..22894
                     /locus_tag="KR257_002227"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428269.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="spore protein"
                     /protein_id="HBH0030911.1"
                     /translation="MDDVSRQNAIKALKQTKMEIAGEYGMNYEDAFEIIENASNKGVL
                     EGYFKKLEKKKNLGQGISRHLE"
     gene            22948..24111
                     /locus_tag="KR257_002228"
     CDS             22948..24111
                     /locus_tag="KR257_002228"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419435.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="D-alanyl-D-alanine carboxypeptidase"
                     /protein_id="HBH0030912.1"
                     /translation="MKKLASTALAILIALTPLSFSFANNKENADANQLNISSKSAILM
                     DVGSGQILYEKDAHKKLPPASVTKVMTMLLIVEALDSGKIKLDDEVQVSETASSMGGS
                     QIFLEPGETQKVDTLLKGIAVASANDACVAMAEHLAGSVEGFVDRMNAKAKELNMNDT
                     HFANTNGLPVANHYTSAHDIALMSRELLKHEMISKYLTTWMDKVVVGKKQVTVGLANT
                     NKLIKHYQGATGVKTGFTQEAKYCLSASAKRGNTHLVAATLGAETSPERFNDASSLLT
                     YGFANYESVKLCSKGDNIATLTLDKADENKVKLVAKEDLNALIKKGSSKEFEKKIEIV
                     KNPKMPIKKGTVLGKIKICKDKKVIGEVELINTKDINKASYLQMLQRIIDNMI"
     gene            complement(24322..24744)
                     /locus_tag="KR257_002229"
     CDS             complement(24322..24744)
                     /locus_tag="KR257_002229"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889078.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF2000 domain-containing protein"
                     /protein_id="HBH0030913.1"
                     /translation="MENKNSKCVMVIDENLPMGIISNTAAIMGITLGKHAPETVGPDV
                     IDKTGNSHLGIIDIPVPILKGNKEIIKDLRKKLYTLEFNDLTVVDFSDVAQSCNLYEE
                     FTQKIASVPEDELQYFGIAIYGNKKKVNKLTGSMPLLR"
     gene            complement(24765..25601)
                     /locus_tag="KR257_002230"
     CDS             complement(24765..25601)
                     /locus_tag="KR257_002230"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438284.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AraC family transcriptional regulator"
                     /protein_id="HBH0030914.1"
                     /translation="MRQEERTVCFDRELKIEAYRFKGIMQKFPNHFHEHYVIGFIEKG
                     QRYLSCKNKEYTTSTGDLLLFNPFDSHTCEQIDDKVLDYRCINIKPEIMKKTVFEITG
                     KNYLPKFNQPVIFRSELVPLLQELHYIIMEEELDFKKEELFFFLIEQLIEEHTEPNLQ
                     SNLENTNIEIQAVCDYLENNYAEHIILDELSTIAGMNKYSLLRNFTKLKGITPYRYLE
                     NIRVNKAKKLLEKGVEPIDAAIQTGFVDQSHFTNFFKNFIGLTPKQYQNIFINDDSNN
                     FK"
     gene            25899..26495
                     /locus_tag="KR257_002231"
     CDS             25899..26495
                     /locus_tag="KR257_002231"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889080.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="site-2 protease family protein"
                     /protein_id="HBH0030915.1"
                     /translation="MLSMNIGEIVASLVGIAMAISIHEFGHAYSAHLLGDDTAKAYGR
                     MTLNPVRHVDPIGLLAMFILKIGWAKPVPVNPNNFKNYKIGNLIVSLAGVFCNVLTAI
                     LCVIINKYVHMYAINTIAEYVFLYSIGFAAFNLLPIPPLDGWGVISTFVPYKWNEYLY
                     KFESMSYIILLIALFTGMYRIILTPIYAVLLKIVYLFV"
     gene            26525..27244
                     /locus_tag="KR257_002232"
     CDS             26525..27244
                     /locus_tag="KR257_002232"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861170.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="segregation/condensation protein A"
                     /protein_id="HBH0030916.1"
                     /translation="MKYNIQLQVYEGPLDLLYDLITKHKIDIKDISIIDITKQYLNYL
                     KMLDKMDLEITSEFITMASKLLEIKSKYLLYKQKDEEEDPRIELMEKLEEYRKFKVAS
                     QDIKENITYVNERFYRNKEEIIIDDNVDLEDISIEAIKNILPYIFKVKTSQIENANDE
                     KLDKIVRKKIISVEEKILYIRDIIKEKIEVTFTNIIKSYENDEIIATFLSILELIKEK
                     EIVVVQDIFFDDILIRKSSEC"
     gene            27246..27785
                     /gene="scpB"
                     /locus_tag="KR257_002233"
     CDS             27246..27785
                     /gene="scpB"
                     /locus_tag="KR257_002233"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428258.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SMC-Scp complex subunit ScpB"
                     /protein_id="HBH0030917.1"
                     /translation="MKREDIKYIIESVMFAYGEPISIKELNYIINKELSSKEIEIMLN
                     LLIEEYREQNRGIQIIKLENKYQMCTNKDYAEYIKKIIEPKKKKSLSQATLETLTIIA
                     YKQPITKVEIEDIRGVKCDKVLQTLFENELIREAGRLNKIGKPIIYKTTDEFLKLLNI
                     ESLEELPPIENYQEVATNE"
     gene            27947..28576
                     /locus_tag="KR257_002234"
     CDS             27947..28576
                     /locus_tag="KR257_002234"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889085.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF2953 domain-containing protein"
                     /protein_id="HBH0030918.1"
                     /translation="MELNELFNFKYLIIAVIFIISVTMLILISHINILIIADIKNKDI
                     CLKLNIKYMFNLININRQLYPAENSKNNDKKEGMKNNIDSSILLADDLLSIYRLLKKI
                     KIHELYSNINFGTGNIGLTSSVYVLINTLYGNLFNMIDAEKMYLNVNPDFTKDYVLGN
                     IRIHIRPRIKALFNIIIMINKIMNKNKGNKEGDSNESNRFDTESYGNNS"
     gene            28530..28958
                     /gene="ytfJ"
                     /locus_tag="KR257_002235"
     CDS             28530..28958
                     /gene="ytfJ"
                     /locus_tag="KR257_002235"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419458.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GerW family sporulation protein"
                     /protein_id="HBH0030919.1"
                     /translation="MRATGSIQSLMETTLETIKGSIDANTIIGDPIKTDTTVVVPISK
                     VTIGFGIGGGEYSKGYDDKDREIELKNEKSDTNFAGGSAGAISVQPVAFVVVESGETR
                     IMSLDSNINLVDNILSITPRVLEKIQNISQSNKNQDKNNM"
     gene            29206..29646
                     /locus_tag="KR257_002236"
     CDS             29206..29646
                     /locus_tag="KR257_002236"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419459.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MarR family transcriptional regulator"
                     /protein_id="HBH0030920.1"
                     /translation="MSDKELSILLLESMNNFHNLIKIINNERYKKDKVLTERQFFALV
                     KIRKHDKIELKNLSRDLHVSTSSLCILLNKLVEQEYVYREEDSRDRRNTFYGITKNGE
                     KILDNEILKFVSIISDKMDCLDIDNKDKLFTSLEESKNIIEQLF"
     gene            29662..31113
                     /locus_tag="KR257_002237"
     CDS             29662..31113
                     /locus_tag="KR257_002237"
                     /EC_number="3.4.11.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902401.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="leucyl aminopeptidase"
                     /protein_id="HBH0030921.1"
                     /translation="MNIKYSKEILKSLENAITVVALFEGEDVSTTFDKINMISRNFNS
                     KENSIDTVTLIENNNLVNVCLVGFGKRELLNREKIRIIGGNLCKKLKNILKNEAYKSS
                     DVNVLNLNLNSDEIGSFVEGILLGNYKFDKYKTKIKDFERKEVDTITIFTEKEVECQI
                     EKAKILANSTIIARNLVNEPSNVIYPKTLAVETVKLGAEFGFNVDVYEEEKIKALGMD
                     AFFAVSRGSINKPRFIVMRYFGDKESTDILGLVGKGLTYDTGGYSLKSNASMLDMKTD
                     MAGAASVIGAMCAISQSKLKKNVIAVVAACENALSGGSYKPGDIISSMAKKTIEVLNT
                     DAEGRLTLADAIYYIINNEKVTKVVDVATLTGAALTLLGNVATPIVTNNDDFYCELEK
                     AATLSGERVWKMPIYDEFKDMIKGEEADLKNTGGKNAGCITAGAFIGEFVGNTPWIHM
                     DIAGTSTSSKSIGYKAKGATGEPVRTLYYLAEI"
     gene            complement(31204..>31838)
                     /locus_tag="KR257_002238"
     CDS             complement(31204..>31838)
                     /locus_tag="KR257_002238"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896207.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=3
                     /transl_table=11
                     /product="YwaF family protein"
                     /protein_id="HBH0030922.1"
                     /translation="VSLFIFGLFLYYCPKLTKNILPYSYTVEKIICTLLVIIMALEQL
                     LLISSGNYSTLNSLPIGINYICIYLCIAILIFKQYHLFNIFFSWSLVCSVGELIFSKN
                     LGYEFPSLIYFIFIFSKCLIIYADIYMVDVRKFRVNRYALRDNLAICFIYFSFIFLLN
                     TFTNSRYYYGFLSHSTTAIFTFIFVTSIMYIPALLFNRDTFILEKKKKSK"
BASE COUNT        12956 a         3266 c         5688 g         9928 t
ORIGIN      
        1 tatttttcct ttattaaaaa tgatatatct aatattaaag gaacaaagta aatcgaatta
       61 aaagtttttg tataattaca aagtataaaa attaatataa gttctaaaaa gtaagaaata
      121 agtataaatt tattctcatt tgataaagaa aaaaatctaa cttgattatt tattataatt
      181 agaaataata ttatcatagt tatgaccgga tacaatgtat tttcaacatt tttcaaatag
      241 cttacaacta atataaataa agataaatat cgtataaaag caactaattt ttctctgttc
      301 attaaaggca ctcctccaaa aaaataaact tttactatga aaactagaat aatatcataa
      361 aagaataaag tcaataaaag tatttattaa tattgatgga aataaaatca atccaaaaac
      421 ttgaatagta aaattgtata ctgacaataa tttaaaagtg aaaatttaat gtattggagt
      481 gaataatgaa taataaagaa aaaggtgatt ttggagaaaa agtagcagtt aattatttgc
      541 tatcaaaagg agcaaagata ctagaaaaaa attacagatt aaagataggg gaaatagata
      601 taatagcaaa aatggaagat gaaattatat ttgtggaggt gaaatcaagg tctaacataa
      661 agtttggcta cccttgtgaa tctgtaagct tcaaaaaaag aaaaaagata attggagttg
      721 caaattatta tattataaaa aataacttaa ataacactcc cgtaagattt gatgttatag
      781 aggtatattt attagaaaaa agaataaatc acataatgaa tgctttttaa aaaagataat
      841 gtttttggaa aggattaaat atgttaagta ttattaattc aagcaactta gtaggaatcg
      901 acagcttttt agttaaggtt gaagtagatg taagcaatgg aatacctagt tttaatattg
      961 ttggtcttcc aggcaaagaa attaaagaag caagagaaag agtaaagtca gcaattctta
     1021 atagtggata taaatttcca agcacgagaa tagttgtaaa tttatcacca gcagatataa
     1081 aaaaagaagg agctttttta gatttatcta taagtatagg ccttttaaga gagttaataa
     1141 aaaaagatga aaattacata agagaaagta tgtttatagg agaattatca ttagatggga
     1201 aaataagaaa agtaagaggt atattgccca taattatggg tgcaaaaact cagaacataa
     1261 aacgtatttt tataccaatt gagaacataa aagaaagtct atttgtagat gaaattgata
     1321 taattcctat taaaagttta aaagaatgtg tcgatttttt aaacgaagag ataaaagtcg
     1381 ataaagtaag gataatgtct tttttggatg ataagtcaag aaaagagaac gaagaattag
     1441 aaaaagataa tagttatata gattgcaaat atactaagat taataatgaa gaaagtaaat
     1501 atgatgaaga ctttaaagat gtaaaaggaa attattttgt aaagaggagt gcagaaattg
     1561 ctgctgctgg aaatcataat atgtttatga ttggacctcc aggctcagga aaaactatga
     1621 ttgcaaaaag agtaaggaca attttaccag atataagtgt agaagaaatg atagaagtaa
     1681 gtaaggtcta tagtatattg ggtatgataa atgaaactaa aggaataatt gataaaagac
     1741 cttttagagc acctcatcat acaactacaa agcaatcttt aattggagga ggaatggatg
     1801 caagacctgg agaaattgct ttagcacata gaggtatctt atttttagat gagatagccg
     1861 aatttgatag aaaaatactt gagactttaa gacaacctat agaagatgga tatgtaaata
     1921 tatccagagt aaagtacagt gcaaaatatc cttgtagagt actgttagtt gcagctatga
     1981 atccatgtcc atgtggttat tatatgtcag agacagagtg tagatgtaga agtaacgaaa
     2041 ttgatagata cataaataaa atatcaggtc cattgttaga taggtttgat atttttgtag
     2101 aagttaattc tataaaatat tcagatttta attctttaaa acaagaagaa agctctcaaa
     2161 aaataaagag aagagtagaa aatgctagaa aaatacagat aaatagattt aagaaggata
     2221 atataaaaaa taatagtgaa attaaagctt acaatttatt taaatattgt aaactggaaa
     2281 aagaagcttc aaaaacggct gagatgatat ttaataaata caacctaagc agtagaagtt
     2341 atacaaaact tttaaaaatg gcaagaacaa tagcagattt agaagaaaga gacttgataa
     2401 attcacagtg tattatagaa gctttttcat ttagaaaggc ttattatagt tattttaaat
     2461 agttttttga ggtggatttt atggaaaaaa gagatactta tttatggtta aaatcaattg
     2521 gtggaataac aacaaaaaca attgaaataa tagaaaatga aatagtaaat attgaagata
     2581 tatttgattt ttctgaaaaa gaaatatata atttaaaaaa tataagcttg aatattagaa
     2641 aaaatatagt aaaatataga ggtcacgctt atttagaaaa tataaaagaa ctactttaca
     2701 aaaaagcgat taaatatatt tgtaaatatg ataaagaata tcctgaaaat ttaaagaata
     2761 tatacaacgc tccaaagtta ttattctaca aaggtgacat aggcttagtt aataataatt
     2821 ttaatatagc tatagtaggt tcaagaaaac ctacagccta tggaattaat tgtgcaaaaa
     2881 caataagttg tcaactatcc caatatggag ttaatatagt aagtggatta gctataggaa
     2941 tagatgcata ctcgcacata ggttgtatga gtggaaaatc taaaactata gcagtacttg
     3001 gttcaggagt agacaatcct cttccaaaac aaaatttaca tttatcaaat aaaatattag
     3061 aaaatggggg attattatta tcagagtata atattaactc gacagtagcc ccgtaccatt
     3121 tttctaatag aaatagaatt atcagtggtt taagtgatgg agtagttgtt gtagaagcag
     3181 caataaaaag tggtgcacta atcacagtgg attttgctct tgaacatgga aaaaatgttt
     3241 ttgcaatacc tggtaatata aattctcaaa tgagtagagg ttgtcataaa attataaaag
     3301 aaggtgcaaa attaattgaa aatatagatg atattttaaa tgaatataac atatttaata
     3361 ttattgataa aaaaataaat caaaaatatg ataatataag tctaaatgcc aagtctaagc
     3421 aaataattga agctataaaa agagaaggaa acttgcatat agatagtatt tgtgattata
     3481 ctggtataga aataaagtat gtaaattcaa taatcaatga attagtacta aatgagttag
     3541 tagtagaaat gaataataaa acgtacagtt taaatgtata aattaagatt aggtagtggg
     3601 ggtgtatggt tttatggcca aaacattagt catcgtagaa tcgcctgcaa aagctaaaac
     3661 tatagaaaaa tttttaggga aaagtcatta cacagttaaa gcatcagttg gtcatgtcag
     3721 agatttacct aaaagtaaat taggtgtaga tatagaaaat aattttgaac ctcaatatat
     3781 aaatataaga ggaaaaggcg atgtaataaa agaattaaaa aaagaagcta aaaaatctaa
     3841 acaagtatat ctagcaactg accctgatag agaaggtgaa gctatatcat ggcatttagc
     3901 tcatatacta aatttagatg aatctgagga ttgtagaata gagtttaatg agataactaa
     3961 ggatgcaatt aaaaaagcaa ttaaacatcc tagaaatatt gatataaatt tggttgatgc
     4021 acaacaggca agaagagtgc tagacagact tttaggttat caaataagtc ctatattatg
     4081 gcaaaaggtt agaaaaggtc ttagtgcagg tagagtgcaa tctgttacaa caaagttaat
     4141 ttgtgacaga gaaaaagaaa taaaggcatt tattccaaaa gaatactgga caatagatgt
     4201 tgaggctaag acagtaaaag acaaagatat aactttgaaa ttttatggta aaaatgatga
     4261 aaagattgaa ttagaaaatg aagaagctgt aaatgaaata ctaaaagaaa tggaaggtaa
     4321 agatttaaag gttgagaaga tagaatctaa atcaagacgt aaatcagctc caaaaccatt
     4381 tacaacaagt atgcttcaac aagaaggagc aaataagtta ttttttacta ctaaaaaaac
     4441 aatgatgata gcacaagaat tatatgaagg tatcgacata gaaggtgaag gtactgttgg
     4501 tcttatatca tatataagaa ctgactctaa aagaatatct gatgaagcaa aagaaaaagc
     4561 taagggctat atcgtaaaca atttaggaga aaactactat aaaaacactg gtgataaaaa
     4621 agaaaaaaag gatactaaaa aggttcaaga tgcccatgag gcaataagac caacctcagt
     4681 tgatagaact cctgagagta taaaagcctc attgagcaaa gaccagtaca agttatacaa
     4741 tttaatttgg agaagatttg tagctagtca aatggaagat tcagtgtttg atatactaaa
     4801 tgtagaatgt aaaataggcg atattgtatt taaggcaact ggttcaaaaa tgaaatttga
     4861 tggttatacc aaggtatata atttttcaga aagagaagac aaaattttac caagtataga
     4921 aaaaggagat atattaaata tagaaaatat attgccagac caacatttta cacaaccacc
     4981 agcaagatat acagaagcta gtttagtaaa aacactagaa gaactaggta taggtagacc
     5041 aagtacgtat gctccaacaa tagctactat actgaataga gagtatgttg aaaagcaagg
     5101 aacaagtcta tgtccaacag aacttggaat aatagttact gatattttgg aaaataattt
     5161 ccataaattt atagatgtag attttactgc tgatatggaa agtaaacttg atgttataga
     5221 agaaggcaat acagattgga aaaagattgt atcagaatca tatgcaccac ttaaagaggc
     5281 tattgaagaa gctcttgaaa atatagaaaa agtaaatatg gatgaagaaa ctgatgagat
     5341 ttgcgagaac tgtgggtcta atatggttat caaatatggt agatttggaa agtttatggc
     5401 ttgtaaaaac tatcccgatt gtaaaacaac tagaccaatt atgaataaaa ttggtgttaa
     5461 atgtccaaaa tgtgaagaag gagatattat acttagaaaa tctaaaagag gtaaagcttt
     5521 ttatgggtgt tctaattatc caaactgtga ctttgtagct tggaataagc caacaggaga
     5581 gttttgtgag aagtgtggtt catatatggt tgaaaaagtg actaaatctg aaacaaaaac
     5641 agtgtgttct aataaagaat gtaataaaga gacaaaagag cataatgacg gaaaagagtg
     5701 aaaattgaaa aaaatcacat aattctcttg aaaaaggttc caatctatga taatctttca
     5761 agtgtaaaca actaatagaa aaataaattt tcattaaatg tgaaaataat attagaaaat
     5821 ataaaaggtt attaaaaggc ctaaatttca tgaggagatg attaaatggc aagtgaagtg
     5881 ttacaaaaaa caaggaaaat aaataaaaca ttacaaacaa gtggtggaag cagtgtctct
     5941 tttgatttac tggccggagc attgggcgac gttttaagtt ctaatgttta tgtagtaagt
     6001 gcaaaaggta aagtactagg tcttcattta aatgatgttc aagacagttc agttatagaa
     6061 gatgagtata ctaagcaaaa gaaattttca gatgaatata ctcaaaatgt gttaaaaatt
     6121 gatgaaacat tagaaaattt aaatggtgag aagatattag aaatctttcc tgaagaacat
     6181 ggaagattac aaaaatatac tacagtagtt ccaatattag gaagcggtca aagattagga
     6241 acattggtac tttcaagata ttcaaattca ttcaatgatg atgatttagt aatagctgaa
     6301 tacagtgcaa ctgttgttgg tcttgaaata ttaagagcaa taggtgaaga attggaagaa
     6361 gaaatgagaa agaaagctgt agttcaaatg gcaataggca ctctgtccta ctccgagctt
     6421 gaagcagttg aacatatttt tgctgaattg gatggaaaag aaggtctact tgtagcaagt
     6481 aagatagctg atagagttgg tataactagg tctgtaatag taaatgcact tagaaaattt
     6541 gagagtgcag gtgtgataga atcaagatca ttaggtatga aaggtactca tataagaata
     6601 cttaatgaca aacttacaga tgaattaaaa aaattaaaaa acaatcaata atctatattt
     6661 tataggttta gattagaaaa ggtatctatt tcaaatagat acctttttta gacgaattat
     6721 taaggtaatg ataagtatat taaaaaggag tgagaaaatg cctttagcag ataaaataag
     6781 accaaaaaca atgaatgatg taataggtca aagtcatata ataggtaatg gaaaaatatt
     6841 gtctaagata ttacaatcta attttttacc aaatatgata ttttttggtc ctcctggtgt
     6901 tggtaaaact acagtagcgg aaataatagc agaaagaagc aataaaagct tctataaaat
     6961 aaatgctact aattcatctt tagaagatat aaaaaaggtg atatcagagc ttggaagtat
     7021 aaataatgta aatggagtcc tattatatat agatgaaata caaagtttta ataaaaaaca
     7081 gcaacaatca atattagaat ttatggaaaa tgggagtata actttgattg ctagcactac
     7141 agaaaatcca tatcattatg tatataaagc tcttttaagt aggtctactg tatttgaatt
     7201 taaaccttta gaaaaacttg atgtagaaaa aggactgaaa agagctgttg aagtattaaa
     7261 tgaagatagc tatatggata ttgagtgtaa taataatgct attgaagata tagcaattct
     7321 ttctgatgga gatatgagaa gagccttaaa tattttagaa gtggtagtct attcaactaa
     7381 accaaataag gataatataa cttatataga ttcagatgta ataagggcat ctacatttaa
     7441 taaaattata aactatgaca aaaatggtga tagtcattat gatattttaa gtgcatttca
     7501 aaaatctata agaggaagtg acccacaggc atctatacac tatctagcaa gacttataaa
     7561 aggtggggat ttgataagta tatgtaggag acttttagta atagctagtg aagatatagg
     7621 tttagcttat ccaaatgcta ttgtaattgt aaaggcatgt gtagactcag ctatgcaact
     7681 tggatttcca gaagcgaaaa taccattagc agaagctact attcttttgg ctacatctcc
     7741 aaagtctaat tctgcatgta tagcaataat gaaagctatg gatgaactgg ataaagagtt
     7801 tgttaaggat ataccaaata gtataaagga ttctcactat tctggttcta aagaaatagg
     7861 taggggttgt ggatacaaat atcctcataa ttttaaaaat cattatgtaa agcaacagta
     7921 tttaccagat agcataaaag atagtattta ttacatacca caagaaaata aaactgagaa
     7981 aaatataaaa aaatatttag aatatctaaa tagtgatttt tagactgaac tttatgtatc
     8041 gggggtagat attatgatta taaaacttaa ctcaacttat cacagtagag ttatgaaata
     8101 cttaaaaaaa gaacctgagt acaatttgtt tataataggg gatattgaaa gatatggata
     8161 tggaaataat tttttaaata tatgggcaga tgtgggtgaa catggtgaaa taaaggcaat
     8221 attacttaaa tattttgaat ttatgatatt ttattctgat ggagagtatg atgttgaagg
     8281 tttttataat ctacttcgta atactaatta cgaagaaata tctgggaaaa tatgtgctgt
     8341 agatgcttta gcaaagagat taggacttaa taatttaaag gtagttgatt tttgcaaact
     8401 tcaaactaaa aagtttttga tagataataa ttgtaatgca aaggttaaaa gaattaggct
     8461 tggaaatcta aaaaagacag tgaaacttta tgacttaata gatgaatttc acagtacaac
     8521 tttagagaat ttaaaaaatg gactaaggac aggtagagga tattgtatag agattaacaa
     8581 acaggtggtg tcaatggcaa agagtacttc agaaaatagg actcatgcaa tgataattgg
     8641 agtaggaaca catcctaaat atagagctaa aggacttgct acaaaatgcc taattaaact
     8701 atgttcagag ttactgagag aaaacaaaat tccttgtttg ttttatgata atgaagaggc
     8761 tggaaagata tataaaaaac taggatttga aaacattgga aaatggggaa tttattcaaa
     8821 ataaaaaatt aaaattaatc ttgacaaaat tagtagggta taataaaatt atcttgaaag
     8881 taattcctac taaaacagta tgaattagat ttctatatag aggtgataat atatgaagtt
     8941 gtctactaaa ggtagatatg gactaaaagc aatgtttgaa ttagcattaa atcaagacaa
     9001 tggaccagta tcattaaaat ttattgctaa gaagcaaaaa atatcagatc agtacttaga
     9061 acaaatattt tcatctttaa aaaaatcggg tctagtaaaa agtgtgagag gtgctcaagg
     9121 aggttatttg ctttcaaaga atgctgaaga cataacagta ggagatatac ttgtagtatt
     9181 agaaggacca gttgcattat ctgactgtgt actagatgaa gatgtatgtg aaaactcaaa
     9241 catgtgtgta acaaaaatag tttgggaaaa gatgaaaaag ggtatagaag atgttataga
     9301 ttcaattact cttaaagata tgataaatga ctataacaaa aataaattag aaaatgatat
     9361 aacaaatatt aaaaaataga tttggagatg aatgtaatgg aaaaaagaag attgtatatg
     9421 gattattctg caacaacacc tattaaaaaa gaagtattgg atgcaatgat gccataccta
     9481 acagattatt ttggtaatgc atctagtttt cacacattcg gaagagaagc aaaagatgct
     9541 ttggataaag caagagaaca agtagcagcc cttataaatg ctgaacctag tgaaatatat
     9601 tttacagcag gtggttcaga aagtgataac tggacactag agggtgtagc ttatgctaat
     9661 aaaaacaaag gtaatcatat aataacttca aaaatagagc accatgcaat acttcataca
     9721 tgtgaatact tagcaaaaca tcatggattt gaaataactt atttagatgt tgatagcgaa
     9781 ggaaaagtag acttaaagca actagaagat tcaataaaag atactactat acttataagc
     9841 ataatgtttg caaataatga aataggaact atacagccta ttaaagaaat atccgaaata
     9901 gctaaaaaac ataagatatt attccacact gatgcagtac aagctacagg taatattcca
     9961 gtagatgtta aagaattagg aatagatttg atgagtatgt cttcacataa aatatatgga
    10021 ccaaaaggtg taggagcttt atacataaga aaaggtgtaa gacttcataa ctttgtccat
    10081 ggtggagcac aagaaaaaag caaaagagct ggtacagaaa atatacctgc aatagttgga
    10141 tatggaaaag cagcagaatt agctaaggaa aatatgcaaa atcatgtaga aactttaact
    10201 cgtcttagaa ataagttaat agatggtgtg ttagaaagaa taccttacac aagagtaaat
    10261 ggtagcttag ataatagatt gccaggaaat gcaaactttg cattccaatt tatagaaggt
    10321 gaaggaatac ttttattatt agatatgtta ggaattgctg gttcaagtgg ttctgcatgt
    10381 acttctggtt cattagaccc ttcacatgta cttcttgcaa taggtttacc acatgaaata
    10441 gcacatggtt cattaagact tacagttgga gattttacaa cagatgatga tatagattat
    10501 atactagaga acttaccaaa agtaatagaa agacttagaa gcatgtcacc actttatgat
    10561 gatgcgaaga aacaaggttt agtaaaatag acataaagat aaagcataaa aaatagacat
    10621 aaattgagta ggaggaaaag ataatgcaat atagtgataa agttatggaa cattttatga
    10681 atccaagaaa tatgggagaa attgataatg caagtggtgt aggtgaagtt ggaaacccta
    10741 catgtggaga tataatgaag atatttttag acatagatgg agatgtaata aaggatgtta
    10801 agtttaaaac atttggctgt ggttcagcta tagcaagttc ttctatggca actgaaatga
    10861 taaaaggaaa aactataaaa gatgcattag aacttacaaa taaagctgtt gcagaagctt
    10921 tggatggttt accaccagta aagatgcatt gttcagtttt agctgaacaa gctgtaaaag
    10981 cagcccttat agattatgct caaaagaaca atatccatat accagaattg gatggatatg
    11041 ttatagatga tgctcatgac catgatgttg aagaagaaga ataaaaataa gtgattgtgt
    11101 tatgagaagt ttacaatgat taaaaagaag tactaatgat ataattagga cataaaaaat
    11161 agctgttttt aaaatggcta ttttttattg cctaaattaa gtattttaac ttgatttaga
    11221 ggttaattag ttaacaaaat aatccataag attcaaataa taaagatgat tattttttta
    11281 gaaaatagaa caagctatat tttaaataag tacaatactt gctctatatg gtataataat
    11341 aagtaatgca aaagatgagg tgaaatttgt ttatgaataa aaaagtaatg ataggtatga
    11401 gtggaggagt tgatagctct gtagctgcat atcttttaaa acaacaagga tatgatgtca
    11461 ttggtgttac tatgaagttg tggcaagatg atgatgttgt tgaaattgaa ggtggttgtt
    11521 gctctttatc tgctgttgaa gatgctagaa gggtagcaaa taaaataggt ataccatttt
    11581 atgttttaaa ttttagagaa gtgtttaaag aaaaagtaat agattatttt atagatgaat
    11641 atttggaagg aaaaactcct aatccctgta tagcttgtaa taaacatata aaatttgatg
    11701 atttttataa gaaggctaga caaataggtt gtgattatgt agctacaggt cactatgcaa
    11761 agatagaaaa ggatgaaagt acaggaagat atttgctaaa aaaatctgtt acagataaaa
    11821 aagaccaaac ttatgcactt tataatctta cacaagagca actagagcat actttattgc
    11881 caataggtga ctatgaaaaa gatagagtaa gagaaattgc taaggaaatg ggtatggcag
    11941 tacacaataa gcctgatagt caagaaattt gttttgttaa agataatgac tatgcaaatt
    12001 atgtaaaaaa acattctaaa aagcgtattg aagaaggttt ttttgtagat actaaaggca
    12061 atatacttgg aaaacataag ggtatattat attatactat aggccaaaga aaagggcttg
    12121 gaattacttt tggaaaacca atgtttgtaa tagatataaa tccaataaat aataccatag
    12181 ttcttggaga caatgaagat ttatttaaaa aggaacttat tgctaaagat gttaacttta
    12241 tatcaataga tacgttagaa gaacccttaa gagttcaagc caaaataaga tattcagcaa
    12301 aaccatcacc agctactatt catagagtag gagaagatac tattaaaata gtttttgatg
    12361 aagctcaaag agctattact aaaggtcaat ctgtagtaat gtatgatgga gatattgtag
    12421 taggtggagg tataatcgag aaaagtttat aaaaacatct aaaaaattaa aaaaataagc
    12481 aataaagtat attaagagta aataaagttt ataaaataaa tttattgtat atgaaaatat
    12541 agtattgatt aattttgtaa aatttagtaa tataattagt atattaatta aaaaacaaat
    12601 acagtgataa ggaatagtaa aatatttgat gtcttacaga gagagggaaa tgctggaagc
    12661 ccttagaata tgatatttga agcagccttt tagtagcaat cttgaacaat ttatctttta
    12721 taaagaagat ttaagtagag attgacggta gttacgttat agctaaggtt ttccgaagat
    12781 atcatacttt gtatgataat tagggtggta ccgcgattgt cctcgcccct ataaatttat
    12841 ttatagggac gaggtttttt atttaaacga aaaaataaaa tttattagga ggaacatgat
    12901 atggaaaaga tgggattaaa tgaaataaga agtaagtttt tagaattttt tgagtcaaaa
    12961 ggtcattatg tagcaaatag ttattcttta gtaccaaaca atgataagag tttgttactt
    13021 ataaactcag gtatggcacc tttgaaaaac tacttttcag gtgtagaagt acctccaagt
    13081 gtgagaatgt gtacatctca aaaatgtata agaacaggag atatagaaaa tgtaggtata
    13141 actgcaagac atgctacatt ctttgaaatg atgggtaatt tctcatttgg agattacttt
    13201 aaaagagagt caatcaaatg gggatgggaa tttgttacag aatggctaaa tataccagaa
    13261 gataagatat gggtgactgt atatgaagaa gatgatgatt cttatgatat atgggcaaaa
    13321 gaaatgaatt tcccagaaga aagaatggtt agacttggaa aagatgataa tttctgggaa
    13381 ataggtacag gtccttgtgg tccttgttca gaaatatatt ttgatagagg agaagaatat
    13441 ggatgtgaca atccagactg taaaccaggc tgtgattgtg ataggtattt agaattttgg
    13501 aaccatgtat ttactcaatt tgatagagat gaagaaggaa attatagtct attagaaaac
    13561 aagaatatag atacaggtat gggtcttgaa agaatgggat gtattatgca aggcgtagac
    13621 actatctttg aagttgatac aattaaatct atactagaag cagttgagaa gttaacagga
    13681 gtaaaatatg gagagaatcc aaaaaatgat atatcaataa gaataataac tgaccacata
    13741 agagctgtaa cattcttagt tagtgatgga gtgcttccat caaatgaagg aagaggatat
    13801 gttcttagaa gactccttag acgtgctgct cgtcatggta agttattagg agtaaaagaa
    13861 ttatttttac agaaactaat agatgaggtt ataaaagtaa atgataaagc atatccagtt
    13921 ttagttgaaa aagaaagtta tattaaaaaa gtagttggaa tagaagaaga aaaattcaat
    13981 gaaactatag accaaggaac agaaatattg aactcttata tagaagtatt aaaaaatgaa
    14041 ggaaagactg tcctaagtgg tcaagaagct tttaaactat atgatactta tggcttccct
    14101 atagacttaa ctaaagaaat attagaagaa gaacatctat ctgtagatga agaagctttt
    14161 aatgaagaaa tggaaaagca aaaagaaaga gctagaaatg ctagaggaaa tatggatgga
    14221 gaaagttgga aggaagaccc tctatcaaaa ttagaatcta cagttgacag tacatttaat
    14281 gggtatagtg aaatttatgg tgaaggaact attgaagcta tagttaaaga tgatgagcta
    14341 gttcaaagtg cagaagaagg cgataaggta tctatagtac tagataacac tactttctat
    14401 cctgaaggtg gaggacaagt tggagattgt ggattgataa ctaatgaaaa cttagtttta
    14461 gaagtattaa atactaaaaa aggtgctaat aatagtataa aacatatagg tataataaaa
    14521 tcaggaagaa taagtaatgg ggacaaagta aagacactcg tagatagaga aactagaatg
    14581 tcagctgcaa gaaatcacag tgctacacat ttacttcata aggcattaag agaagtatta
    14641 ggagaacatg ttaatcaagc tggttcttta gtaactccag aaagacttag atttgatatt
    14701 actcactttg aagcaatatc aaatgaagaa ttaaaagtaa tagaagaaaa agtaaataat
    14761 gttattttat catctttaga cataaaatgt gatattatga atataaagga agctaaagaa
    14821 aaaggagcta cagcactatt tggtgaaaaa tatggtgatg aggtaagagt agtttctatg
    14881 ggagattatt ctacagaact ttgtggagga actcacttga caaatacttc tcaagtagga
    14941 atgttcaaaa tattatctga aggtggagta gcagcaggtg taagaagaat agaagcaata
    15001 acaggaaaag ctgtttatga atacctaaaa gaaagagatg gaattatctc tgaagtttgt
    15061 gtaaacttaa aatctaaaga agataattta attcaaagaa taagttcttt attagaagaa
    15121 aataaaaact tatctaaaga attgcatgat atgaaagcta agatgagttt acaatcagtt
    15181 gattctattt ttgattctaa agttgaagta aatggagtta atttgataac taataaattt
    15241 gaaggtatgg atatggatac actaagagaa acagcagata atctaagaga taagcttggt
    15301 tctggtgtag tagtacttgc aaatgtagta gatgataaag ttaactttgt agttactgcc
    15361 actaaagatg tattagataa gggaatacat tcaggtaata ttgttagaga agttgcaaaa
    15421 atagctggag gaaaaggtgg aggaagacct aatatggcac aagcaggagc tagtgatgta
    15481 tctaaggttg accaagcttt aagctatgca agtgaggtta ttaagacaca agttaaataa
    15541 cattcactca aggaggtttt tagtttggaa aaagatttag actacactat gaaatttgaa
    15601 ggaataccag aagataggat gagtgtagga gatactattg attttgtata taaagcatta
    15661 gttgaaaaag gatataaccc tataaatcaa attatagggt atctcctttc tggtgattct
    15721 agctatataa ctagtcataa aaatgcaaga gctataatta aaaaatttga aagagatgag
    15781 atacttgaag aagtaatcac gcactatctg aatagaaagt aggtcaaata aatgagaaaa
    15841 aagattatgt cgttgtttgc aatagtcatt atgatttttg tatcaactgc tagctatggt
    15901 tttgctgaag aaaaaggcaa ggtcatattt attgatatga ataggaccaa tcttggaagt
    15961 atgatgaata ttccaatctt gaaaaatgag atagaaaaga gaggctatgt agctctcatg
    16021 aatataagag gggatcaagg tactgatgat agaaggtctt gtgcaagtat gggtgcagga
    16081 acaagagcta gtgtaactac tgaagactat atcaattttc aaaaagtaga ccaagatact
    16141 gctaaagctt ttgaagtcgc aacaggtcaa aaagctaaag aaataaatga tttaggcatt
    16201 aatagatcta taaatgaaaa tcttgagtat ggagaatatg gagcaaattt agggtcatta
    16261 ggaaaaactt tatcagaaaa tggtttaaag acatctgtaa ttggaaatgc tgatataatt
    16321 gaaaataatc aattagttaa aaacagaaac ttatgtttag tagctatgga ccaatatgga
    16381 aggattgatt caggtaatat tgataatatt aataagaaag attctaaaat gccatttgga
    16441 atatctacag attatgataa attactagat gaaactaaaa aatcctataa aaatagtgat
    16501 gctatatttg tagaacttgg agatacatat agattagata tgtatagatt aaatctaaat
    16561 gataatactt atgatacaat gaagaaaaat attgtaaaaa atataaataa atatcttgaa
    16621 caagtatttt ctatggttgg agaaaatgac actgtttata tagcaagtgc atttccaagt
    16681 gacctagatt ataagaataa gagaagactt tctccaataa taaaatttag tggagaaggg
    16741 aaaggtctac tggaatctgc cacaacaaga aaggctggaa ttgttgccaa tttagatgtt
    16801 ggagtagata tactaggtac atttggtctt gaaaataaag agatggtagg tagaagttat
    16861 actttagtaa ataaagagga caatattagc tatctaaaat cactttatga aaggatagtg
    16921 tctatatctt caataaggtc aactattata aatggctttg taggcgtaat atctgcttct
    16981 tgggtaattg ccatgtttgc gattttcttt agaaattata tgccacataa agagcgtgta
    17041 ttcaaagtac ttaaggagtt tataaaatta ggcataataa tgccactatc atttatgtta
    17101 gctcctttga tgaattttaa aactccaatt tcaatatctt tgggaatatt tgcaactacg
    17161 ctaatattat acttgttagg tagaaaatta tttaaggaca atgatataaa gcacatggga
    17221 ttttttgcaa cacttactat tttagtcata gttatagatt ctgtatttgg aacatactta
    17281 atgcaaaata acataatgag ttatgatgct gtcataggag ctaggtacta tggtgtagga
    17341 aatgaatatg aaggtgtaac tatagcaagt gcagtatttg gcttagcagt attattacat
    17401 tataagaagg tatctaaatt acttgttgta attttttcat taataatact tataactagt
    17461 gcatatcctt caatgggtgc aaatgttggt ggagctatat cagaatgtgt agcatatttg
    17521 ttgtttataa tgcttatata tgacattaaa atagatttta agaaagctgt attattagct
    17581 gtttcagctg tagttgtcgt ttttgcattt gcagctttag atatactttc aggtagtgaa
    17641 tctcatttag gtatgtttgt acagagaatt ttcctaaatg gaccaggaga gatattacaa
    17701 acatttggaa gaaaaattca aatgaatatg caactagcac agacaagtgt atgggtaaat
    17761 attttacttg taggaattgg agtaattgca gtgcttatat ttaaaccatc tagacacttt
    17821 agaaagataa tgaataattt tccaatcttg tttaaagggt ttattgcatc tatggttggt
    17881 tgtataatta ctcttttagt taatgattct ggaatagttg ctgcatctac agcatctata
    17941 tatatactta taccactaat aataataagt ataaatatga taatatttga aaaaaataac
    18001 taaaaaaatt tttactgttc atataggatt taaataaaaa atgcaatatg attattaatg
    18061 taaactggat gcttacataa aaaatcatat tgcaattttt atgattgata atgtaaaatt
    18121 ctatgaagca gtaagcctgt gaccttagtt atgagaggtt cagaatatgt atttaatcta
    18181 tagaatataa atagataaag gaggaactat gttagatgga agaataatgg gtcttgatgt
    18241 tggtgataaa actattggag ttgctgtgag tgatttgatg ggattaactg cacaaggtgt
    18301 aaaaacaata aaaagagttg gcaagaaaaa agatattgaa gagctaaaag caataataaa
    18361 agaaaaacaa gtaaataaaa ttgtatcagg attaccaaaa aatatgaatg gaactttagg
    18421 tccacaagga gaaaaagtaa tcaagttttg tgaattggta aaagcagaaa caggtattga
    18481 tgtagagttt tgggatgaga ggctttctac agtagcggca gagaggtctt tattagaagc
    18541 agatgttagt agacaaaaaa gaaaaaaggt tatagatatg ttggcagcag taataatttt
    18601 gcaaggatat ttagatttta aaataaattc ataaaagaac tataaaattg aatacttatg
    18661 atatataata taaataataa aaataaaaat aaatttgagg tgaatgacat tatggaagaa
    18721 aatataataa atttaataga cgaaaatggc gttgaaagcc aatttgaaat aatattaaca
    18781 ttagaagcag aaggaaaaga gtatgcaata ttaatgcctt tagatgatga agaagctgaa
    18841 gaagctttaa tctttagaat tgatgaggat gaagaaggtg aaatcttaat acctttggaa
    18901 agtgatgaag agtatgaaac tgttgtagct gtgtatactg ctataatgga agaagaaggt
    18961 ttaaattacg acgaagatga atcaaatgga cttaactaga taagtaatta agtttgtata
    19021 taaaaatcag atatttatta tatttgcttt aattaaacct tattaattgt aaaagcattt
    19081 atagtatata tctgtttttt tgttttttat taaaaatacc aaaaaattta tgaattttgg
    19141 tgaataatat atcttttatg ggtatatatt tatattatga gaataaatta aatttattta
    19201 aatgtcttga caaaaaatga attatcaatt acaatattat ttaataaaga ttatcaattg
    19261 aaaatagtaa gggtgatgtt atggcaaata caatggattt attaaaagac aagttaaaag
    19321 aaactggttt taagattacg ccacaaagaa gagcaatagt tgaaatattg cttaaacatg
    19381 accattcaca tctaagtagt gaggaaatct atgatttagt tagggttgac tgtcctgaaa
    19441 taggcttagc tactgtatat agaacaatgc agctattgga tgaaatagga ttaatatcaa
    19501 aactaaactt agacgatgga tgtataagat atgagattag tctacataaa gaagactgtc
    19561 ataatcatca tcatcttatt tgtaaaaatt gtggaaagat aatggaagct aaagaagacc
    19621 ttttagacaa tatagaaaaa gagatacaat cattgtacaa atttaaaata cttgatcatg
    19681 atgttaaatt ttatggacta tgtgacgagt gtaatggagt aagcgattca gaagaataaa
    19741 cttctattgc ttaatgtcga tggaagaata gtatagaact tttatattct atgctattct
    19801 tccatttttt attataaacc atctataaaa tgcaaatata cagttttcaa agtgattata
    19861 gttttaatat tgaaaatata attaatccta taagtacaaa aatgaatgat ttttctatga
    19921 aattactaaa tggtcctcca acagttaaaa accctaaaga aattttcttt tcgcttaggg
    19981 gataaaaaat tggtattcct tgctttgtaa ataaatctcc taaaaacata tggcttgcat
    20041 aaccaatcgt accataaaaa gataaattat taatattagt gattaattct atctgtttta
    20101 gtaaaaaata tactattata gttgcaaata tgctatgaga aaaacttctg tgctttaacc
    20161 aggggaaaat tgacaacatt agacaaaaaa ttgtaaaata tatttcaact tctatgatgt
    20221 ataagcatat agctaatagt ataaatatta atgatagaaa aacttttctt agaaatgtat
    20281 gggttagttt tgcttcaata attataattg caacaaatgt aattattgcg cttaaataaa
    20341 aattatcatt tatatttatt gaaataaaga aaataataat attaacagca tatataaaaa
    20401 ttctatatat gtatttggat acattgtttt ttagaatgaa atttgagacc atagaattag
    20461 atttatccaa atcgggtagt acagcaaaag tagctgaaac taaaatatca actaaagata
    20521 taggaatttt aaatattaaa gatgtctgga tagctgttaa gattcctatt gcacaatgag
    20581 ttttaccacg cataaatcct cctaaattat ccgatattaa atcatataat atttagagga
    20641 tatcaaaata aaataggttt gtcaaaataa tacgttaaat gtattttaaa tatagcttaa
    20701 aatatgatac gaattatggt acaataagaa taactggtag cgagtgcgtg atttgatatt
    20761 atttatgatt gtagaacgtg ttaaaaaatt aaatagacag aaggagatga tgcaattgtt
    20821 caaaaagaac accaataaga taaaggtaat ggccttgggt ggacttaacg aagttggaaa
    20881 aaatatgact gttgttgagt ataaagatga aataattgtt atagatgctg gacttagttt
    20941 tccagaggat gaaatgttag gagtagatat agttatacca gatataactt atttagtaaa
    21001 aaatagggat aaaataaagg gtatatttat tacacatgga catgaagacc atataggagc
    21061 tcttccatat atattaaaga aaataaatgt acctgtatat ggggcaagac ttagtatagg
    21121 tcttatacaa gtaaaactta aagaacataa gatgaataat gttaagttaa atgttatagg
    21181 tcctagacaa gttataaagc ttgataatat ggaagtagag tttttgaaaa ataaccatag
    21241 tataccagat gcttactcta ttgcaataca cacagaccaa ggtataatat accacacagg
    21301 agattttaag attgacttga ctcctattga tggagatgtt atggatatgc atagaatctg
    21361 tgagttgagc aaaaaaggag ttcttttaat gctggctgat agtactaatg cagaaaaacc
    21421 aggatttact atgtctgaaa agactgttgg ggtaggtctt gacgaattat ttgcaaaagg
    21481 aaatggcaga agaattatag ttgctacctt tgcatccaac atacacagat tacaacaaat
    21541 aataaatact gctgagaagt ttaatagaaa agttgctata tcaggtcgct caatggtcaa
    21601 tgtagttgga gttgcaaaag aattaggata tctagatatt tctgatgaca tgcttataga
    21661 tttaaatgat atatgtaagt atgaagatag tgaattagtg ataataacaa ctggttcaca
    21721 aggtgaacct atgtcagctc ttgctagaat ggctttttca gagcacaaaa aagtagaaat
    21781 aaagagtggc gatttagtta taatatctgc tcatccaata ccaggaaatg aaaaattaat
    21841 atcaagagta atcaatttct tatttgaaaa aggagcagaa gtagtataca gtgatatagc
    21901 tgatatacac gtttctggac atgcctgtca agaagaatta aaacttatac atgcattagt
    21961 tagaccaaag ttttttatgc cagctcatgg tgaatataga atgttaaaaa gacatgctga
    22021 aatagctgaa cagcttggta tggataaaga aaatattttt gtcatgcaaa caggagatgt
    22081 tttagaatta gataaaaact ctgctaaggt agcaaatcgt atacaaacag gaaacatatt
    22141 agttgatggt ctaggagtag gcgatgtagg taatatagtt ttaagagata gaaagcattt
    22201 atcagaagat ggtcttatga tagttgtagt tactatttct aaggatgagg gtaaagtttt
    22261 agcaggtcca gatataattt ccagaggatt cgtatatgta agagaatcag aagatttaat
    22321 ggatggagca aaggatataa ttaagaatgt tctaaatgaa tgtgaagaga aaaatattaa
    22381 agaatgggct tatttaaaga ataatattaa agaaaaccta aaagaatatt tatatcaaaa
    22441 aactaaacga aatccaatga tacttcctat cataatggaa gtataatata aaaaaactat
    22501 aaatttgaaa attagacctc ttgtaatttt taaagtaata tcaaaaatcc aattgatatt
    22561 atcttaagaa ttacaagagg tctttttaat acttgattta aaaaaatata tatattacat
    22621 aaaataccaa ttataacaat cttttattag taaaaactac ttatatataa attttactga
    22681 taggaggatt cttatggatg atgtttcaag acaaaatgct ataaaagctt taaaacaaac
    22741 aaaaatggaa atagcaggag agtatggaat gaattatgaa gatgcttttg aaataataga
    22801 aaatgcgtct aataaaggtg ttttagaagg ttactttaaa aagcttgaaa agaaaaaaaa
    22861 tttaggtcaa ggtatatcta ggcatttaga ataaaaaaag ttaaatgtga gaaaataagt
    22921 ttaaataaac tttaagaggt gacatcgatg aaaaaattag ctagtactgc tttggctata
    22981 ttaattgcgc ttactccctt aagcttttct tttgcaaaca ataaggaaaa tgctgatgcc
    23041 aaccaactaa atatatcttc aaaatcagca attttgatgg atgttggtag tggacaaatt
    23101 ttatatgaaa aggatgctca taaaaagctt cctcctgcta gtgtaactaa ggtaatgact
    23161 atgctactta tagtagaagc tttagattca ggcaagatta aacttgatga tgaagttcaa
    23221 gtaagtgaaa ctgcatctag tatgggtggt agtcaaatat tcctagagcc aggagaaact
    23281 caaaaggttg atacattgtt aaaaggtata gctgttgctt ctgcaaatga tgcttgtgtt
    23341 gctatggctg aacacttagc tggaagtgtt gaagggtttg ttgatagaat gaatgctaaa
    23401 gcaaaagagt taaatatgaa tgatactcat tttgcaaata caaatggact tccagttgca
    23461 aaccactata catctgctca tgatatagct ttaatgtcta gagaactatt aaaacacgaa
    23521 atgataagta aatacttaac tacatggatg gataaggttg tagtagggaa gaaacaagtt
    23581 acagtaggtc ttgcaaatac taacaaactt ataaagcatt atcaaggagc aactggtgtt
    23641 aaaactggct ttactcaaga agcgaaatac tgtttatcag catctgcaaa gagaggtaat
    23701 actcatctag ttgctgcaac tttaggagca gagacttctc cagaaagatt taatgatgcc
    23761 tctagccttt taacctatgg atttgctaat tatgaaagtg ttaagttatg tagtaaaggt
    23821 gataatatag caacacttac attggataag gctgatgaaa acaaagttaa attggttgct
    23881 aaagaagatt taaatgctct tattaaaaaa ggaagttcta aagaatttga gaagaaaatt
    23941 gaaatagtaa aaaatcctaa gatgccaatt aaaaaaggaa ctgttttagg aaagataaag
    24001 atatgtaaag ataaaaaagt aataggcgaa gtggaattaa taaatactaa agatataaat
    24061 aaggcaagct atctacaaat gcttcaaaga ataattgata atatgatata aataattatc
    24121 agatgaaata taattataat acacaaagat atgattataa tacacataaa aaataccctt
    24181 atgtaattat ttgccatagg ggtattttta tttactatat agaagtattt tataatctta
    24241 tgatttttat agaaatatag aaaagtttat gtatcttaaa atatcatttg atttaatatc
    24301 atatataggg ttgtttaaca attatctaag taaaggcata ctaccagtaa gtttattcac
    24361 tttcttttta ttcccataaa ttgctatccc aaaatactgt aactcatctt ctggaacact
    24421 agcaatcttt tgtgtaaatt cttcataaag attgcaactt tgtgctacat ctgaaaaatc
    24481 tacaacagtt aaatcgttaa attccaaagt atataatttt ttacgtaaat cttttattat
    24541 ttctttgttt ccttttaaaa taggtacagg aatgtcaata attcctaagt ggctattacc
    24601 tgttttgtca attacatctg gcccaacagt ttctggggca tgttttccta gtgtaattcc
    24661 cattatagct gctgtattgg atataattcc cattggtaaa ttttcgtcta ttaccatgac
    24721 acattttgaa tttttatttt ccatttttat ttctcctttt taccttattt aaagttgttt
    24781 gaatcatcat ttataaatat attttgatac tgctttggtg taagaccaat aaaattctta
    24841 aaaaagtttg taaagtgact ttggtctaca aatcctgttt gtatcgcagc atctataggt
    24901 tctacgcctt tttctaaaag ctttttagct ttgtttaccc gtatattttc taggtatcta
    24961 tatggtgtaa taccttttaa tttcgtaaaa ttacgaagta gagagtactt attcatacct
    25021 gctatagtgc ttaattcgtc aagtattata tgttcagcat aattattttc tagataatca
    25081 catactgctt gaatttctat atttgtattt tccaagttag attgcaaatt tggctctgta
    25141 tgttcttcaa ttaattgttc aattaggaag aaaaaaagct cttccttttt aaaatccaat
    25201 tcttcttcca tgattatata gtgtaattct tgtagtagag gtactaactc actgcgaaat
    25261 ataacaggtt gattaaattt tggtaaataa tttttacctg taatttcaaa gacggttttt
    25321 ttcattattt ctggcttaat attaatacat ctgtaatcaa gtactttatc atctatttgt
    25381 tcacaagtat gactatcaaa agggttaaaa agtagcaaat ctccagtact tgtggtatac
    25441 tctttatttt tacaagataa atatctttga cctttttcta taaaaccaat tacataatgt
    25501 tcatgaaaat ggtttgggaa tttttgcatt atgcctttaa atctatatgc ttcaattttt
    25561 aattccctat caaagcatac tgtgcgttct tcttgtctca cttaggtaac ctcctttcat
    25621 gttatacaaa gtgtaacaca tattttttta tacttcttgt ataatattga ctaagagaca
    25681 ataatgtcaa ttcatgtcaa tataatatta cacttacagt aggtgtaatt attatatttt
    25741 cacaatgaat atgatataat aataaaagtt ataaaataaa aagcaaattt taattttatg
    25801 cctagaagtt aaaattatta taatgtaaaa taattttgat tataagctat ttaattgtta
    25861 taataatatt aaaaatttaa tttaggagat gtacattaat gttaagtatg aatataggag
    25921 aaatagtagc aagtttagtt ggtatagcta tggcaatatc aatacatgag tttggccatg
    25981 cttattcagc tcacttattg ggagatgata cagctaaagc ttatggtaga atgacattaa
    26041 atcctgtaag acatgttgac ccaataggtc ttttggctat gtttatcctt aagatagggt
    26101 gggcaaagcc agtaccagta aatccaaata actttaaaaa ctataagata ggaaacctga
    26161 tagtttcact tgcaggcgtt ttttgtaatg ttttgactgc tatactgtgt gtaattatca
    26221 ataagtatgt gcatatgtat gctataaata caatagctga atatgtgttt ttatatagta
    26281 ttggatttgc agcttttaac ttacttccga tacctccact tgatggatgg ggagttatat
    26341 ctacatttgt accatataaa tggaatgaat atttgtataa atttgaaagt atgagttata
    26401 taattttatt aattgcttta tttactggta tgtatagaat aatattaaca ccaatatatg
    26461 cagtgttgct aaaaatagta tatttatttg tttaatataa taaacagatt aaagagggat
    26521 tgatatgaag tataatatac aattacaagt ctatgaggga ccattagatt tactttatga
    26581 tttaataaca aagcataaaa tagatataaa ggatatatcc ataatagata taactaagca
    26641 gtatctaaat tatttgaaaa tgctagataa aatggattta gagataacta gtgaatttat
    26701 aactatggca tcaaaacttt tagagataaa gtctaaatat ctgctttata agcaaaaaga
    26761 tgaagaagaa gacccaagaa tagaacttat ggaaaagtta gaagaatata gaaagtttaa
    26821 ggtagcatca caagatataa aagaaaatat aacttatgtt aatgagagat tttatagaaa
    26881 taaagaagag ataattattg atgacaatgt ggatttagaa gatatatcaa ttgaagcaat
    26941 aaaaaatata cttccataca tatttaaagt taaaacatca cagatagaaa atgctaatga
    27001 tgagaaacta gataaaatag taaggaagaa aataatatct gtagaagaaa aaatattata
    27061 tataagagat attataaaag agaagattga agttactttt acaaatatta taaaatcata
    27121 tgaaaatgat gaaataatag ctactttttt atctatatta gagcttataa aagaaaaaga
    27181 aatagtcgta gtacaagata tattttttga tgatattcta ataagaaaaa gttcggagtg
    27241 ttaaaatgaa aagagaagat ataaagtata ttatagaatc tgttatgttt gcatatggtg
    27301 agccaataag tataaaagaa ttaaactata taataaataa agaactttca tcaaaagaaa
    27361 tagagattat gttaaattta cttattgagg agtacagaga acaaaataga ggtattcaaa
    27421 taatcaagtt agagaataag taccaaatgt gtacaaataa agactatgca gaatatataa
    27481 agaagattat tgaaccaaag aaaaagaaaa gtttgagcca agctacatta gaaactctta
    27541 ctataattgc ctacaaacaa ccaataacaa aggtagaaat agaggatata agaggagtaa
    27601 aatgtgataa ggtattacaa actttgtttg aaaatgaact tataagagaa gctggtagat
    27661 tgaataagat agggaaacca ataatttata aaacaacaga tgaattttta aagttgttga
    27721 atatagaaag tcttgaagaa ttgccaccta tagaaaatta tcaagaagtg gcaacaaatg
    27781 aataaaaata taaaatcaca ataatttagt atgtaatttt aaattttaaa agatttaaaa
    27841 tgctctaagt tgttgtgttt ttttgtataa atataaaatt ataattctct taaaataaat
    27901 atggataatt aagtataaat agtaattttt tgatgataat ataaacatgg agcttaatga
    27961 attatttaat tttaagtatt taataatagc tgtaattttt attataagtg taactatgtt
    28021 gattttaata tctcatataa acatcttaat aatagctgat ataaaaaaca aagatatttg
    28081 tttaaagctt aatataaaat acatgtttaa tttaataaat ataaatagac aactttatcc
    28141 agctgaaaat agtaaaaata atgataaaaa agaggggatg aagaataata tagattcaag
    28201 tatattatta gctgatgacc ttttgagcat ttatagatta ttaaaaaaga taaaaataca
    28261 tgaactttat tcaaatatta attttggaac tggaaatatt ggcttaacat cttctgtata
    28321 tgtattgata aatactttgt atggaaattt atttaatatg attgatgcag aaaaaatgta
    28381 tttaaatgta aatccagatt ttacaaaaga ttatgtttta ggaaatataa ggatacatat
    28441 aaggccaaga ataaaagctt tatttaatat tataataatg attaataaaa ttatgaataa
    28501 aaataaagga aataaggaag gtgatagtaa tgagagcaac aggttcgata cagagtctta
    28561 tggaaacaac tcttgaaaca attaaaggtt ctatagatgc aaatactatt ataggagacc
    28621 ctataaaaac agatactaca gtggttgtac ctatatcaaa ggttacaatt ggctttggta
    28681 taggaggagg agaatactca aaaggatatg atgataaaga tagggaaatt gaattaaaaa
    28741 atgaaaaatc agatacgaat tttgctggag gtagcgcagg ggctatatct gtacaaccag
    28801 tagcatttgt agtagttgaa agtggagaga ctagaataat gagtttagac agtaatatca
    28861 atctagtgga taatatatta tctataactc ctagagtatt ggagaaaatt caaaatatat
    28921 cacaaagtaa taagaatcaa gataaaaaca atatgtaaga ataaaatatt tttaaatatg
    28981 tatatagttt taggtaaagt agtggggtta gtataaatcc cactattttg ttgtgtactt
    29041 taaacattta tatctaataa gattttagtt taaaacaatt taaatagata ataaagttga
    29101 tatatagtat aattataaaa agaaaagaag tattatatta tagatatata aacgcatttg
    29161 agatataaga gggagttata aatcattagt tttgaggtga atgttatgag cgataaagaa
    29221 ttatctattt tgttgttaga aagtatgaat aattttcata atttaataaa gattattaat
    29281 aacgaaagat ataaaaaaga taaggttctt acagaaagac agttctttgc cttagtaaaa
    29341 ataagaaaac atgataaaat agagcttaaa aatctaagta gagatttgca tgtatctact
    29401 tctagtctgt gtatactact taataaattg gttgagcaag agtatgtata tagggaagaa
    29461 gatagtagag atagacgaaa tactttttat ggaataacta aaaatggaga aaagatattg
    29521 gataatgaaa tactaaagtt tgtatctata ataagtgata aaatggattg cctagatata
    29581 gataataaag ataaattatt tacttctttg gaagagtcta aaaatataat agaacaatta
    29641 ttttaaaaag gagaatttat tatgaatata aagtattcta aagaaatatt aaaaagttta
    29701 gaaaatgcta taacagtagt agctctattt gagggagaag atgtttctac gacatttgat
    29761 aaaataaata tgataagcag aaattttaat tctaaagaaa atagtataga tactgtaaca
    29821 ttgattgaaa ataacaattt ggtaaatgtt tgtcttgttg gttttggtaa gagagagtta
    29881 ttgaatagag aaaaaattag aatcataggt ggtaatttgt gtaaaaaatt aaaaaatata
    29941 ttgaaaaatg aagcatataa gagtagtgat gttaatgtac tgaatcttaa tttaaatagt
    30001 gatgaaatag gttcttttgt agaagggata ttacttggaa attataagtt tgataagtat
    30061 aagacaaaaa ttaaggattt tgaaagaaaa gaagttgata ctataactat atttactgaa
    30121 aaagaagttg agtgtcaaat agaaaaggct aaaatattag ctaattcaac tataatagct
    30181 agaaatctag ttaatgaacc atcaaacgta atatatccaa aaacattagc agtagaaaca
    30241 gttaaacttg gtgcagagtt tgggtttaat gttgatgttt atgaagaaga aaaaataaag
    30301 gcattgggaa tggatgcttt tttcgctgtt tcaagaggct caattaataa accaagattc
    30361 atagtaatga gatactttgg agataaagaa agtacagata tattaggttt agtaggtaaa
    30421 ggattgactt atgatactgg tggatattct ttaaaatcaa atgcttctat gctagatatg
    30481 aagacagata tggctggtgc tgcgagtgtt ataggtgcta tgtgtgctat atctcaaagt
    30541 aaattaaaga aaaatgttat agcagtagtg gctgcatgtg agaatgcttt atcaggaggt
    30601 tcatacaaac ctggagatat aattagttct atggcaaaga aaactattga agttttaaat
    30661 acggatgcag aaggtagact tacattagct gatgcaatat actacattat aaacaatgaa
    30721 aaagtaacaa aggtggttga tgtagctaca ttaactggtg ctgctttaac attgttaggt
    30781 aatgttgcaa ctcctatagt aacaaataat gatgattttt attgtgaatt agaaaaagct
    30841 gccactttat caggggaaag ggtatggaag atgccaattt atgatgaatt taaagatatg
    30901 ataaaaggag aagaagcaga ccttaaaaac actggtggta aaaatgctgg atgtataaca
    30961 gcaggagctt ttattggtga atttgttggg aatactcctt ggatacatat ggatatagcg
    31021 gggacaagta catcatcaaa atcaattgga tacaaagcaa agggggctac aggagaacct
    31081 gttagaacat tgtactattt ggcagaaatc taaaaaacaa ttataaaata taatttataa
    31141 agccacgtgg atatttttgt aatttaagat tatctatgtg gctttatttt ttatttaaat
    31201 aaattattta ctctttttct ttttttcaag tataaaagta tctctattaa ataaaagagc
    31261 aggtatgtac ataatactag taacaaaaat aaacgtaaaa atagcagttg tgctatgact
    31321 taaaaaacca taatagtacc tagagttggt gaatgtgttt agtaaaaata tgaatgaaaa
    31381 ataaataaaa catatagcta agttatctct aagtgcatat ctgttaactc taaattttct
    31441 aacatcaacc atatatatat ctgcataaat tatcaagcac ttagagaaga taaagataaa
    31501 atatattaag ctaggaaatt catagcccaa gtttttagaa aaaatgagtt ctccaactga
    31561 acaaactaaa ctccaagaaa aaaatatatt aaaaagatga tactgcttaa aaattagtat
    31621 ggctatacac agatatatac aaatataatt gattccaatt ggtaaagagt ttagagtact
    31681 ataattacct gaagaaataa gtaataattg ctctagagcc ataattatta caagtaatgt
    31741 acaaattatc ttctcaactg tatagctata aggtaaaata tttttggtta gttttggaca
    31801 atagtataaa aataatccaa atataaagag acttacaa
//
LOCUS       DAEPID010000043        31499 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.043, whole genome shotgun sequence.
ACCESSION   DAEPID010000043 DAEPID010000000
VERSION     DAEPID010000043.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 31499)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 31499)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..31499
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.043"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            158..271
                     /locus_tag="KR257_002239"
     CDS             158..271
                     /locus_tag="KR257_002239"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013483530.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
                     /protein_id="HBH0030923.1"
                     /translation="MIMGRHLWNPSYFVATVLENTEEQIGKYINNQKKQVK"
     gene            273..1391
                     /locus_tag="KR257_002240"
     CDS             273..1391
                     /locus_tag="KR257_002240"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861600.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
                     /protein_id="HBH0030924.1"
                     /translation="MIVVEKAYKFRMYPNKKQQELINKTFGCCRFVYNKYLAKRIEVY
                     KNDKETFTYKQCSSDLTNLKKELKWLKEPDKFSLQNVLKDLDNAYKKFFKEKAGFPKF
                     KSKKINRFSYKTNFTNGNIMYCGQHIKLPKLGMVKIRDKQVPQGRILNAAISKEPSGR
                     YYVSLCCTDVDIEAFENTNNQIGLDLGIKEFCISSCGEFIENPKYLKKSLNKLAKLQR
                     ELSRKTIGSLNRNRARLKVARLQEHIANQRNDFLQKLSTKLIKENDIICIEDLQVKNM
                     IRNSKLSRLISDVSWSEFIRQLEYKANWYGRQIVKVGKFFASSQICNKCGYKNEEVKD
                     LNIREWICPSCNETHDRDINASINILKEGLRLITIQNK"
     gene            1542..2759
                     /locus_tag="KR257_002241"
     CDS             1542..2759
                     /locus_tag="KR257_002241"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890757.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS ascorbate transporter subunit IIC"
                     /protein_id="HBH0030925.1"
                     /translation="MLIGLIAAFGLVLQKKKASDVIKGSLLAAFGIIIMETGTGMLVS
                     SIAPINGAFQSISGGAVTKGLSDVTFTASYGGIIGLAMFAGLAIHLMIARFTPIKTIF
                     LTGHMLYWFPFIFVASGVEAGLNGGVLITFAAVLSALYWSIMPWLLRKYVFDVIGDDS
                     FTLGHPSGCLALISGFVAKLVGNKEKSTEDINIPQSLSFFREISISGGMAVFLMFIVV
                     GIVIPGAFKDSNEFIGTYAIKQGLSFGAGLIIMLHGVRMLINQIMPAFQGISEKVVPN
                     ALPAFDCPILFNYKPNAVLIGFLVAMLTSTAMILIYNYFNVFNLLLIPLVITSFFECG
                     AAAVIGESQGGIRGAIIGTAIAAIFMVVLVGISAVIYSGTIQNWILIFGGNDLSLFGI
                     ISRFIGSLFGGIL"
     gene            2762..3502
                     /locus_tag="KR257_002242"
     CDS             2762..3502
                     /locus_tag="KR257_002242"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454865.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SIS domain-containing protein"
                     /protein_id="HBH0030926.1"
                     /translation="MKFKYIDEIRRLIDIIENEEKVNMEKAVQIFVEAIESKNAIFSF
                     GASHAGILTEELFYRAGGCVLINPVFAKSLMLDTAPITHTSKMERLEGYGTALADKTP
                     IKKGDVVIVHSVSGRNPVSIEFAMKAKENKAIVICITNLSYSKSVSSRHSSGKKLYEV
                     CDLVIDNHGQKGDACVEIDGLNQKVSPTSTVIATTVMNSIIAQATQELVNKGLKNPPI
                     FYSANIDGGDELNKKIFDEYKSVIHYEY"
     gene            3825..5135
                     /locus_tag="KR257_002243"
     CDS             3825..5135
                     /locus_tag="KR257_002243"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729386.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sugar ABC transporter substrate-binding protein"
                     /protein_id="HBH0030927.1"
                     /translation="MKKENKMEGIKVGMLKKLCSLAMVAIMTTTLITGCSSGNGKDSK
                     KDGEKEKLVLWMPPVENNMKEVWDPILDKFEEKNNCEVDLQIIPWDNYSEKFATAISA
                     GEGPDVGYMYAEMYPQFIESGAVEDLTNYATKEDKEQSIYIKTSEMMGGMYGMPFQAA
                     NPGVLYYNKDILEKLGEKPPKTWEDFKRICKKATQDTDGDGKIDQWGLAQGWGAKTFG
                     NLNWNWYPYLWQAGGDIFNDDLKSVKFNDKSGLEAANFLKELQAYVPEDSLSKDSNEM
                     IESVFGPGKAAFTIMLSSAATSVFDESFPDLNWGFVTGLEDKKAATFGAVDHLSLMSS
                     AKNKELAYKLIQHMLSVESMTEFHKAIPRAPITKGEPYQGDERFKEMVENDKNVYRPL
                     VVGPHGVEIYEYLWKELQTMISGDKTPKQALDDAAKYSNDLLAQ"
     gene            5233..6150
                     /locus_tag="KR257_002244"
     CDS             5233..6150
                     /locus_tag="KR257_002244"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416320.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sugar ABC transporter permease"
                     /protein_id="HBH0030928.1"
                     /translation="MENLVREFEENSKRKKTKLNIKPYMYILPLGIILVAFYVIPIIM
                     SIYFSFTKYNIISPATFIGLENYKKLFTDETLKVSIINTIKFTVVVVPCQTILSLILA
                     VWITGKGNSKIASFAKGAIFIPVLSSMVLIGMVWRALLNGEGSIIYQVLGAFGIESSK
                     LLGDSKTALPTLMFISMWKNIGYFMVIYISAIMNLPKHCYEVAKVDGATKLQEFIKIT
                     VPLLKPTTIMVVFLGSIWSLQVFDLIYTVTGGGPGISTMSIVMHAFNLNFKNFNSGYA
                     MTVANVLFLLIAVVSILQNKLVRRDNSDF"
     gene            6166..6975
                     /locus_tag="KR257_002245"
     CDS             6166..6975
                     /locus_tag="KR257_002245"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416323.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="carbohydrate ABC transporter permease"
                     /protein_id="HBH0030929.1"
                     /translation="MKTARRLLSDGLLLFIACASLVPFIYMLIISLKITYNSYSLDIS
                     FSTVTLQNYIDIFTKKGFAQYFFNTAIVSFSGVLLNLVFSTLAGYSFAKMDFKGSDKL
                     FLFMIMTLIIPSQVTMIPLYIIMKHLGWINSYLALIMPIPTAFGVFIMRQAILGVPKE
                     LLESAKIDGCSDFRILIQIVLPLIKPALITLAIFTFMGAWNEFMWPLIATTKDTMRTL
                     TVGLSTLKTFQITNYGQMMAGATITFLPPFIFYLILQSKFVEGVSLSGIKG"
     gene            7033..8781
                     /locus_tag="KR257_002246"
     CDS             7033..8781
                     /locus_tag="KR257_002246"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454861.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4091 domain-containing protein"
                     /protein_id="HBH0030930.1"
                     /translation="MEISYVLKDCTFKHNKYSVVEAETWKDKDLDIVVAKGEKFAFQI
                     MLKATEEFNCTIDKSSAISWKGLGNRVRLALNMPNSLENNFSINILGYVQDDTKAFVN
                     DAILRDKDVLVEQYLPQTFWIEGQVPEDFEENNLDIGIDIFKSFGYEDEEKVCTIDVP
                     VKVRNVVLKPLDESKFFLDLWQHPSCLARMYKVELWSDIHFEIVDNYLKELASLGEKV
                     ATVIVSDYPWAGQSCYKVYKNPSNLYEYNMVSVSKGLDGKIKCNFESMDRYISIADKY
                     KMAKEIDLFGLLGNWCAGEFGNPVEGYKDPIRVRYFDEKDKVFKFINNTNDLKEYIGL
                     VLNHLIECGLWDRVRIIADEPNNPEVVKECIEFINSTVSTHQVKYKSATHDQNFLDRA
                     KDEIDDMSINLKLTIQNYKDIESLKKKINDKGGILTWFVCCFPEKPNSFLSSPFVENR
                     IIGWYTYYFGLDGFLRWDYNLWTEDPWKDSSYKFPIWKAGDMFFVYPGKDLKPVRSVR
                     MENLRFGIQDFELFTMLEKEKGREYIEVELMQELLNKKENAEIKGFGDIELGYSLDNW
                     GYDKVKKYVLELLDRV"
     gene            9043..10065
                     /locus_tag="KR257_002247"
     CDS             9043..10065
                     /locus_tag="KR257_002247"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890750.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycoside hydrolase family 5 protein"
                     /protein_id="HBH0030931.1"
                     /translation="MFGGINIKRIGIIIMFFLSISFIGFYLVIRDNSDTVKMQRGINI
                     GNALESPKDFPWDVKMSNKFFDDIKDAGFDTVRIPVRFSDYTSDSDNFKIDEEFFKKI
                     DKYVDYALDKDLIVVLDLHHFEEIMKEPRVHKEKFLKIWQQIANRYQKYDKKLVFELL
                     NEPKENLYSQLLNEYIEEAIKIIRKTNPKRTIIVGPYNFYQIDYLNELNIPKDSNIVV
                     SFHYYEPNDFAFQGNIYHKGFEHLSNITWEGTNEQMDYLKKRFDTVENWANKNKVKIF
                     LGEFGITKEAPEASRRAWIKAVREEAEKRNFSWAYWELASGFGIYNQIEGTWDRDILS
                     ALIEKR"
     gene            10070..12376
                     /locus_tag="KR257_002248"
     CDS             10070..12376
                     /locus_tag="KR257_002248"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454859.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase"
                     /protein_id="HBH0030932.1"
                     /translation="MKKNSKKILITLTIITNVIYILWRIFYTVPKEEGKFALICAIIL
                     LFVEIMGMMEMFVHYYGMSNIEYPEKPIISEELYPHVDVFIATYNESVDLVRKTVNGC
                     IHMQYPDKKKVHIYICDDGNREEMCILAEKMGVNYITRTEREGAKAGNLNNAMQHTNS
                     PLIATFDADMIPMHDFLIATVPYFLKNEQAKKDGEKEEYEKVGFVQTPQSFYNPDLFQ
                     FNLHSEGRIPNEQDYFYRDIQLARNRTNSVIYGGSNTVISREALEEVDGFYTYSITED
                     FATGILIQSKGYRCYAIPEVHASGLSPTDLKSLIKQRERWARGCIQTGRRLNILFRRG
                     LGFWQKISYISSITYWYASIKRFVYIMAPILFSVFNVIVVKCTLLQVLVFWLPMYILS
                     SLSLKIFSQNIRNTRWTNIYETIMFQSLMPAVILETFAISKNKFSVTNKSKLEENRMY
                     KFLQGIPYFIYMVLSIIGILKMFVAIFKMSSMTYSVVLFWLIGNLFNLVMATLFISGR
                     QQLRKSERYIAEIDFKLKQNSYVLSSKTIDISENGFAFLLENPEYISPEEEFEVEFRE
                     KSGNEMYIANMKAKIVNVVEVNSKWKYAAYITHIEDSEIDNWMCIVHDRIPTLPMTIS
                     NQLGFFDDLQINVKKRIEKTRTLSRRSPRINMNFQMDIKNTGKLRIVNFNYQYVLLNF
                     ENKSIYPKEIALEINENIVLECDLCEGKIDERGILYKVNNIDSIMQNFFLRDEMMDWI
                     LQNKKILDSKPSEKKEKSIDEFEPMEYI"
     gene            12348..13463
                     /locus_tag="KR257_002249"
     CDS             12348..13463
                     /locus_tag="KR257_002249"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897746.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0030933.1"
                     /translation="MSLNPWNIFRRDEMKTLKVFFCSTKYLILVFIFFINTTFISSAT
                     SDKILDLSFKKIETDLSSKITYEDTGVKIETDSSKSDKERYLYIYQNIKENWSMYNNF
                     YIEIQNKNKSSQRINLSIQSKNMLEFRLKEGSEVFLEGKNIIYSDKIKEGCIEVPGEF
                     EGKIYVNFNSLINEESNVVLDSNMLSNIVSWGITFIPSDEEHNIVIIKKISLLSEEKL
                     RFLNNIKIIGDEEVQIPVLGQSISQYEVLGLKSDSKIKYSLMGKQDNVSISQNGKLTL
                     SNKAKPGQIILQVNVDDKFKIGKKITLTESWSINKKDKDGVPYTLVSPEQSPTVQDMK
                     KINFMNNIITFVRILFVSLVIICFGIYLYWKKCSKTK"
     gene            13481..14899
                     /locus_tag="KR257_002250"
     CDS             13481..14899
                     /locus_tag="KR257_002250"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416335.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MBOAT family protein"
                     /protein_id="HBH0030934.1"
                     /translation="MLFSSLIFLFYFLPITLVLYYVFRFNRTIQNMILLAVSLFFYAW
                     GEPKFVVIMIVSIIMNYIFGLLVDRYRESKIKVKVFLVLMCAYNIGVLFIFKYLAFAL
                     RNISELISTELTIPNIILPIGISFFTFQGMSYVIDVYRRHGEVQKNPFYVGLYIAFFP
                     QLIAGPIVRYESVAEQILNRKETWNKFSIGTCRFITGLGKKVLISNNMAIVADYIYTM
                     NSQGEIAASLAWLGSIAYTLQIFFDFSAYSDMAIGLGLMFGFKFEENFNYPYISKSIS
                     EFWRRWHISLGMWFKSYIYFPLGGSRVANKDIMIRNMFIVWLFTGIWHGAEWTFVIWG
                     ILNFVFLIIERFIMFEKIENHNFIKHIYALLVVNFGWVLFRSPNLKEAYNYFKAMFGG
                     NGAIWSDYTYMFLKEYWVFFIFAFIFSVPIAKKINKFVVEQAKYSMIFNVFYPISAIL
                     LFFISVTYLVTGSYNPFIYFNF"
     gene            14914..16122
                     /locus_tag="KR257_002251"
     CDS             14914..16122
                     /locus_tag="KR257_002251"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003431084.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0030935.1"
                     /translation="MNRFFKVRLITAIMFLIILFAFSIFNVCYSGKDTIQEIKNSIAE
                     KSSLKDTISSIDNTVNDKVIYKNTFIETYGYLQKLMGKNEFSKFSVVKDTSGKMHYTY
                     FAKAPNPVGVIADRVRKFSDEMEKQNTKLVYLMTPDKYIKGVTKFPKGIPYSYSNETA
                     DNFLNQLKKYNVDYIDFRENILKSGIPKDDLFFKTDHHWKVETSFWAFGELVEQLNKK
                     YNMNLDENHYYRDKDNYNSIVYPKSFLGSMGRKTGILYGGIDDFTLIYPKFKTNYTYY
                     TDSKSQKFELKGRFEESLILSYPFNADLDLMDGQSDKYFTYLLGNRPLVKIKNIENPD
                     GLKVLFVKDSLIVPTAAFFSSVCSSIDMIDPRYYDGDILEYAKSHDYDFVFISVYPQN
                     LTKEFFPFCE"
     gene            complement(16196..17584)
                     /locus_tag="KR257_002252"
     CDS             complement(16196..17584)
                     /locus_tag="KR257_002252"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861591.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cation:dicarboxylase symporter family
                     transporter"
                     /protein_id="HBH0030936.1"
                     /translation="MESSFLSQFLMITDFKTIFFIILLLGTFFIVRQFEKKKIKFSLR
                     TIYATVLGLILGIIIQAFAGFPNDTTQVTWLQEVSKWYSLFGSGFMDLLKMLVVPLVF
                     LSIIKVIINMKDNNLGTLTFKSLGMLLATTAIAAIVGIIVANIMKLGVGANMPTLVEN
                     QELKEINSLVDTLRGLLPSNPVMAMANGNIVATIIFATFIATSIKRLSKKHFETIKPF
                     IDFIEASYKIIVSVSMTVIKFMPYAVVALLANTITSQGISSIVSVLQFILALYISVAI
                     LFIIHLIFITLNGLNPITYIKNSTEALLLAFTSRSSLGTLPVTIESLVQNHGVDEGVS
                     SFTASLGANMGMNGCAGIYPALMAVTLANMAGVNMDMSFYVMLLIVITISSFGIAGLP
                     GTATMAVSVVISGVGLGSYFPLVGGILAIDPILDMGRTMINVNGAMVSSITVGKSLGK
                     IDKEVFSKKNIS"
     gene            17925..19259
                     /locus_tag="KR257_002253"
     CDS             17925..19259
                     /locus_tag="KR257_002253"
                     /EC_number="1.8.1.14"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893646.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CoA-disulfide reductase"
                     /protein_id="HBH0030937.1"
                     /translation="MRVIIIGGVAAGMSAAAKLKRIKPEYEVVVYEKTEIVSFGACGL
                     PYFVGGFFNDADELLARTPEKLREAGIDLNIFREVVEVDSESKKIKVKNIKTDEIYED
                     YYDKLMIATGARSIMPPIKNIKLKNVSTLKSLYDGEYLKKLLSNEDNKRVTIIGAGFI
                     GLEAVEACKKLGKDVDVIQLEDRILPQVFDKEMTDVLEEEINRHNVNLHLDEMVVELC
                     GEDKVEKVITNKGEIDTDVVIIATGVRPNTEFLSNTNIKMLKNGAIVVDEYGRTSVED
                     IYSAGDCATIKNIVSNENVYVPLATGANKLGRIVGENLAGREVSYQGSLSSSCIKIMD
                     MEAASTGITEKQAKDLGINVKSKFISDYNQTHYYPGRNKIYVKLIYDADTKVILGGQV
                     AGFKDAVQRANVLAAAIFGKMTTNQLGMLDLCYAPPFARTWDVLNVAGNVSK"
     gene            complement(19401..20318)
                     /locus_tag="KR257_002254"
     CDS             complement(19401..20318)
                     /locus_tag="KR257_002254"
                     /EC_number="3.1.26.11"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011969064.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribonuclease Z"
                     /protein_id="HBH0030938.1"
                     /translation="MIDLTLLGCGGNVPMPNRFLSSVFINYKGRKILIDCGEGTQVSM
                     KLKKCGFKDIDLICITHLHGDHIFGLLGLLSTIGNSGRTSDLTIVGPVGIVDCIRSMR
                     NLVEYVPYTLKIIENPQGNFSLDNKVLRNLEISTISLEHSIECLGYSFNFRRNPKFDI
                     DKATKNEVPKILWNKLQEGQNIVLDSKQYTPDMVLGELRKGVKISLTTDTRPIESIPD
                     FIKDSDLFICEAMYGDDLDISKAVRNKHMTFREAANLAKLGNVKQLLLTHFSPSLDIP
                     SMYLENATNVFENTILGEDRLSLRLNFDE"
     gene            20526..21410
                     /locus_tag="KR257_002255"
     CDS             20526..21410
                     /locus_tag="KR257_002255"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003431076.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4846 domain-containing protein"
                     /protein_id="HBH0030939.1"
                     /translation="MKVLKKITILSLITLTLVGCSNGEDKKVVEGSKKIQNSKKDEQP
                     IIVHKDANILKDRYEPPKGFKRVDVEKGSFESFLRNTKLKNYGEKVKYYDGRTKESKG
                     IYDSVFDVDIGNRDLHQCADAIMLMRAEYLYQNKLYDEISFDFVDGFKAKYSKWAQGY
                     RISVKDSGSSWYKATEYSTSYESFRKFMDIVFAYSGTLSLEKELEPVKVEDMKIGDVF
                     IVGGSPGHASIIMDMAENEKTGEKVFMIAQSYMPAQQTQLLINRKNPNLSPWYSLDFE
                     GDLTIPQWTFKRDQLKRF"
     gene            21623..23464
                     /locus_tag="KR257_002256"
     CDS             21623..23464
                     /locus_tag="KR257_002256"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729380.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="5'-nucleotidase C-terminal domain-containing
                     protein"
                     /protein_id="HBH0030940.1"
                     /translation="MKIRRYLILVIIILITTSQSFISYGLERFEEITIFHTNDIHGRY
                     AEGDDHIQIGNLATLKKETPNSILVDAGDCLHGLPIVNMDRGKSAIELIKCAGYDYIT
                     PGNHDFNYGKDRLFELSKSANLGENTLKFLSSNIFENGKKVFDSNDIKEIDGIKIGFF
                     GLSTQETKSKTGFKNVEGLEFKNPIESATEQVNELKGKGANVIVAICHIGTNSLSKPN
                     SIDIANEVQGIDLIIDGHSHTKFENGKQVGDTLIVSAGQYLENIGEIKLTLDTNDVEN
                     IKIENKSVRLIGKEEALKYKLDSAVSKKVDEIKEQQEKILDKVIGVTTNTLDGSYENV
                     RTKETNLGNLISDILLDKTKADISLFNGGNIRDTIEKGNITRRDIVDVFPFSNTIVTK
                     ELTGAQIKDVLEHGVKLYPEKSSAFLQVGGISYYFNPKQKEGEKITNIQKEGKPLDLN
                     KKYVVATNDYIASGGDEFPCFSKEPVLKEFGNLESAVIEYIEYKKEISKNVDGRIGIK
                     SKDELISKNHESDLILSENEKNINDNEENLSNNIKSSDSDKNKSLDKTSARESSNLGI
                     SKREAKEKSPKTGDLGFSNSIIIFIVSSTLICLLNFNQKELKDKKSK"
     gene            23769..24476
                     /locus_tag="KR257_002257"
     CDS             23769..24476
                     /locus_tag="KR257_002257"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861589.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HBH0030941.1"
                     /translation="MNNILLLEDDKSLNRGISFKLKKEGYNVFSAFGIEEAKNIFAKE
                     EICLIISDIGLPDGSGFDFCEEIRKKSDVYIIMLTALDEEVDIVTGYDLGADDYITKP
                     FSLMVLISKVNALMKRVNTVKNYTLLVCDDLFFYYIENKLIIRTDDKEEEIILSKTET
                     KLLKYLMENSMQTLTKEQLLESLWDSSGNFVDDNTIAVNIRRLRQKVEKNPSEPKYIK
                     TVRGVGYMWGERSIKKC"
     gene            24470..25780
                     /locus_tag="KR257_002258"
     CDS             24470..25780
                     /locus_tag="KR257_002258"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003431070.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HAMP domain-containing histidine kinase"
                     /protein_id="HBH0030942.1"
                     /translation="MLKNMNLKDGLSVKDDYIMRRVIVYSVLSVLIVTLVFILFEYSR
                     LHKLYEHQIKNTQNIAGILIEKYPNDEIDIVNSIYNSDYSKVSTGEKAFKKFGYGLEN
                     KMSNDKNFSLYLKSFFKESFFIFLMMFIVVIGIIYYFIRYINKRLSKIYFIVDKMSQE
                     NYLKDTTESEETGYLVEYNEYFKEGIFSKINNCLYELNRSLKIKFIKLEKEKESVKSL
                     VTDISHQLKTPLASLKLYNTLLIEEELEEDEANEFLLTNKASINKLENLINSLVNISR
                     LEISMINIKKEDNDIKNTILNAVKSVTPKAKSKSITLNLNEFNSRIIPHDKKWTEESI
                     FNVLDNAVKYTQVNGEINISVEETANFFKIIIEDNGIGIEKNEFNNIFKRFYRGSADE
                     IESVEGSGVGLYLSRKILEEQGGNIIVSSKVGIGSKFSLFLTTM"
     gene            25897..26580
                     /locus_tag="KR257_002259"
     CDS             25897..26580
                     /locus_tag="KR257_002259"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454838.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBH0030943.1"
                     /translation="MKILYTENLSKHYGKGESLVRALDNVDLEINEGEFVAIIGKSGS
                     GKSTLLHMIGGLDIPTSGKVYIDNKNIFTLKEEELAVFRRRKIGFIFQSYNLIPSLNV
                     WENVVLPIGLDGREVDESFIKELLKSLGLENKHDVLPNTLSGGQQQRVAIARALATRP
                     AIILADEPTGNLDSKTSDEVMSILKSMSKKYSQTLVMITHDDSIAQMADRVIFIEDGR
                     VSKVGDKND"
     gene            26573..28960
                     /locus_tag="KR257_002260"
     CDS             26573..28960
                     /locus_tag="KR257_002260"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861587.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="FtsX-like permease family protein"
                     /protein_id="HBH0030944.1"
                     /translation="MINTTKIAKSNLKQNKSKSILIIITIILSTLMLSSIGIYIVDAG
                     AYQKENTIKYSGNYQGILANVDEKQADILSNHADVELTGEMNGVGVEKLEDDSNISLA
                     YMNEDALKLNSFEFIKGKLPSKENEIVLDSGALKALGYKNKDLGEKIKISYDDYKNDK
                     KIEKEFIISGILKTSEISEAGKYYYAIISESYMRNTRDMSQEDFNIYVKFNDKSNLSI
                     EQAKEKLDKIANDIGLDTINTAVNENYINALKPDMETIMGGVFVGLVIVLSSILVIYN
                     IFYISIVTKVQEFGKLRAIGATKKQIKNIVFKEGFILAGIAIPIGIILGYVLANIIIK
                     SFMDIDVKSSRLPVILSVVVISFISVVLSLLKPMKVASKVSIVDAVRYTGNKISNKSK
                     RKGYKNINLKRLSHANLERNKKRTYMTLASLILSGTIFITVSTALESFDAEKMAREHF
                     PYDIEVRLSGYEMNSDKNPKDNLNILQMDNPLSKDFFNQIKNMEGIKRIESARSVKIG
                     MEDYDVEFKYDLLQSINENDVKSLNKNIIDGKINLERLQTGDEIVITHVDTAKEMGVK
                     AGDKIRLTLYDGDKKIKKEFKVQAIAMGVPSFGIGKDFIDRTLKYDSTSSLGIYTEEG
                     KYQEIKDSIKKIAKNNGFLETDFIDSRIESNKATISFIKIMGYTLTGIIGVIGFMNLV
                     NTMITSIVTRKKELGMLQAIGLTNKQLVKMLNSEAIYYTSGMMIGSILFGGILGYIAV
                     IFLKKTGLSYATYSLPIVPILLMIVCILIAQFITTYLIGRSFNKESLIDRVRYSE"
     gene            29240..30382
                     /locus_tag="KR257_002261"
     CDS             29240..30382
                     /locus_tag="KR257_002261"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003431065.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alanine--glyoxylate aminotransferase family
                     protein"
                     /protein_id="HBH0030945.1"
                     /translation="MNKKINYAPGPTETRENVRLARAEKTTNPDIDIDFVEFYKKTCE
                     KFGNIIGTKNDVYILSGEGILGLEAACASLTEKGDRVLVIDNGIYGEGFKDFVTMYGG
                     EYVLFSSEYTKSIDIDELKAFLDEDSNFKYATVVHCDTPTGVLNDVSKICPLLKKYGI
                     LTVVDSVAGMVGERLSVDESKIDIILGGSQKAISAPAGLTIVGISQDAKNCIKNRKTD
                     VIGFYCNLNIWEGYYEKKYFPYTMPISDIMGLDKALDNILEEGIENVLNRHEKIAYSV
                     RKSIEEYGLELFLEEGYSNTVTAIKIPESIGALELTDYMLKNYNTLVATSLNQYMDTI
                     LRIGHMGENANLNKIEHVLNVLDKSLSALGFKGNGNLLNLFNKYYF"
     gene            30401..30925
                     /locus_tag="KR257_002262"
     CDS             30401..30925
                     /locus_tag="KR257_002262"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416384.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ECF transporter S component"
                     /protein_id="HBH0030946.1"
                     /translation="MEVTAKQKFTTKDMVETSLLIALVFIATKFINIRLPISINGGLV
                     HLGTAMLFISAIVFGGKKGALSGAIGMSLFDLISGWTLWAPFTFIVRGVMGYLLGKIA
                     WANGNNGNNFLINVIGICVSSIWMLFGYYVTEVILYGNFIVPLTSIPGNLMQVLIGLI
                     IALPISKVLKKCIK"
     gene            31025..>31499
                     /locus_tag="KR257_002263"
     CDS             31025..>31499
                     /locus_tag="KR257_002263"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729376.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AraC family transcriptional regulator"
                     /protein_id="HBH0030947.1"
                     /translation="MLSVTRYSIKNVRLKPWVKFIWYFETKSNILLNNKLLPTDSIDI
                     ILNLSDVMEYKIENQDYTASNMHFNGIRDKHGFIIQHGNIRVIGISFYPFGLYPFLKI
                     PISEFNRQIVDLEAVSQLFAKKLEESLNPTQSVEKIVLYLEEVLLSILEEDLISNK"
BASE COUNT        12367 a         3277 c         5520 g        10335 t
ORIGIN      
        1 cttacggttc ttatatatgt tatttaaaaa taaatataaa aaaccttcaa aatacttgtt
       61 ttaagtaatt gcatatttta atattatgat aagtgatgaa aaatggaagt tactcatggt
      121 agaggatatg catatagtat gtcaaatata gacatccatt attatgggga gacatctttg
      181 gaatcctagt tatttcgttg ctactgtatt agaaaataca gaggagcaga taggaaaata
      241 tattaataat cagaaaaaac aagtaaagtg aggtgatagt agtggaaaaa gcttataagt
      301 ttagaatgta tccaaataaa aaacagcaag agttaattaa caaaactttt ggatgttgta
      361 gatttgtata taataagtat cttgctaaaa gaatagaagt ttataaaaac gataaagaaa
      421 cttttactta taaacagtgt agttctgatt tgaccaattt aaaaaaagaa ttaaagtggc
      481 ttaaagaacc tgacaaattt tcactacaaa acgtcttaaa agatttagat aatgcatata
      541 aaaaattctt taaagaaaaa gcaggatttc ctaaatttaa atcaaagaaa attaatagat
      601 tttcatataa aactaacttt acaaatggaa acattatgta ttgtggtcaa catataaaac
      661 tacctaaact tggtatggtt aagataaggg ataaacaagt acctcaaggt agaatactta
      721 atgctgctat atctaaagaa ccaagtggta gatattatgt atcattatgc tgtactgatg
      781 tagatattga agcatttgaa aatactaata atcagatagg tttagattta ggaattaaag
      841 aattttgtat ctcaagttgt ggagaattta tagaaaatcc taagtatctt aagaagtcat
      901 taaacaagct tgctaaatta caaagagaat tatcgagaaa aacaatcggt agtttaaata
      961 gaaatagggc aagattaaaa gttgcaagac ttcaagaaca tatagctaat caaagaaatg
     1021 attttctaca aaaactatct actaaattaa taaaagagaa tgatattatt tgcatagaag
     1081 atttacaagt aaagaatatg attagaaata gtaaactatc tcgcttaatt tcagatgtat
     1141 catggtcaga atttattcgt caattagaat acaaggctaa ttggtatggt agacaaattg
     1201 taaaggtagg taaattcttt gctagttcac aaatatgtaa taaatgtggg tataaaaacg
     1261 aggaagttaa ggacttaaat ataagagaat ggatttgtcc tagttgtaat gaaactcacg
     1321 atagagatat aaatgcaagt ataaatatat taaaagaagg attaagacta ataacgattc
     1381 aaaataaata acatatgtaa gaaccgtagg aactacgggg atagcctgtg gagaattagt
     1441 aagacatatt ttagtatgca aaattctatg aagcaggaac cctgtgactt tagtcatggg
     1501 aggttcagtt tatttcaaat aatattttac gtaatccatc tatgttaatt ggattaatag
     1561 cagcatttgg tcttgtacta cagaagaaga aagcatctga tgttataaag gggtcactac
     1621 ttgcagcttt cggaattata attatggaga ctggaacagg tatgttagtt agttcaatag
     1681 caccaattaa tggagctttc caaagtataa gtggtggtgc agtaacaaaa ggtttaagtg
     1741 atgttacttt tactgcaagt tatggtggaa ttataggttt agcaatgttt gcgggtttag
     1801 ctattcacct aatgatagca agatttactc ctattaagac aatcttctta acaggtcaca
     1861 tgctttattg gttcccattc atatttgtag cttcaggagt tgaagctgga ttaaatggtg
     1921 gagtattaat aacttttgca gcagtattat cagcactcta ttggtcaata atgccttggt
     1981 tattaagaaa atatgtgttt gatgttatag gagatgattc ttttacatta ggtcatccat
     2041 ctggttgttt agcacttata tcaggatttg ttgctaaatt agtaggaaat aaagaaaaat
     2101 ctacagaaga tataaacata cctcaaagtt tatcattttt tagagaaata tctataagtg
     2161 gtggaatggc agtgttttta atgtttatag ttgttgggat agtaatacca ggtgcgttta
     2221 aagatagtaa tgagtttatt ggaacgtatg caataaagca aggtctttct tttggagcag
     2281 gtcttataat aatgcttcat ggggtaagaa tgctaataaa tcaaataatg ccagcatttc
     2341 aaggtatatc tgaaaaagtt gtgccaaatg cactacctgc ttttgactgt ccaatattat
     2401 ttaattataa accaaatgct gtattaatag gattcttagt tgctatgcta acatctacag
     2461 ctatgatttt aatatataac tactttaatg tatttaattt gctacttata ccacttgtta
     2521 taacttcatt ctttgagtgt ggagcagcag cagtaatagg agaatcacaa ggtggtatac
     2581 gtggagctat aataggtaca gctatagctg caatatttat ggtagtttta gtaggaatat
     2641 ctgctgtaat ttactcagga actattcaaa attggatact aatatttgga ggtaatgacc
     2701 tttcattatt tggtataatc agtaggttta taggttcact atttggagga atattataga
     2761 tatgaaattt aaatacatag atgagataag aagattaatt gatataatag aaaacgaaga
     2821 aaaagtcaat atggaaaaag cagtacaaat ctttgttgaa gcaatagaaa gtaaaaatgc
     2881 tatattttca tttggagctt cacatgcagg aatattaaca gaagaattat tctatagagc
     2941 aggtggctgt gttcttataa atccagtatt tgcaaaatct ctaatgttag atacagcgcc
     3001 tataactcac acaagtaaga tggaaagatt agaaggatat ggtacagctc tagctgataa
     3061 aactccaatt aaaaaaggag atgtagttat agttcattca gtatctggta gaaatccagt
     3121 aagtatagag tttgctatga aagctaagga aaataaggca atagtaatat gtataactaa
     3181 tttaagttac tcaaaaagtg tatcttcaag acattcttca ggaaaaaaac tttatgaagt
     3241 atgcgattta gtgatagata atcatggtca aaagggagat gcctgtgtag agatagatgg
     3301 attaaaccaa aaagttagtc caacttctac tgtaatagca actactgtga tgaactctat
     3361 tatagctcaa gctactcagg aattagttaa taaagggcta aagaatcctc cgattttcta
     3421 tagtgccaat attgatggtg gagatgagtt aaataagaag atttttgatg aatataaaag
     3481 tgtaattcat tatgaatatt aaggttaaaa aaatatgtta atgaactttg aagtttatca
     3541 acaaagaata ttaataatat ataataaatg ctatcattta aaagctgtag gtaaaaatct
     3601 acagcttttt attattgtag attaaaaaga tgcgtaatta aattttaaat tggagaaaat
     3661 aaattggaag gtatcaatta taaatattag aaacgttgtc atagaaaaaa actatattaa
     3721 aaaaaagtac atagaaaaaa ctgattagac aataaataca tgctttgata atattttaaa
     3781 tggaatgaaa atgtgtagaa ttataatgaa aaaagaaaat aaaaatgaaa aaagaaaata
     3841 aaatggaggg aataaaagtg ggtatgttaa aaaaattatg ttcactagct atggtagcaa
     3901 ttatgactac aacacttata acagggtgtt caagtggaaa tggaaaagat tcaaaaaagg
     3961 atggcgaaaa agaaaaacta gttctttgga tgccaccagt agaaaataat atgaaggaag
     4021 tttgggaccc tattttagat aaatttgagg aaaaaaataa ctgtgaagta gatttacaga
     4081 taattccttg ggataattat tctgaaaaat ttgcaacagc tataagtgct ggcgaaggtc
     4141 cagatgtagg atatatgtat gcagaaatgt atccacagtt tatagaaagt ggagcagtag
     4201 aagatttgac taactatgca actaaagagg ataaagagca atctatttat ataaaaacat
     4261 ctgaaatgat gggtggaatg tatggtatgc cattccaagc agcaaatcca ggggtattat
     4321 actataacaa ggatatttta gagaaactag gagaaaaacc tcctaaaaca tgggaagatt
     4381 ttaaaagaat ttgtaaaaaa gcaacgcaag atactgatgg tgatggaaag atagaccaat
     4441 ggggattagc tcagggatgg ggagctaaaa cttttggtaa cttaaactgg aactggtatc
     4501 cttatttatg gcaagctggt ggagatatat ttaatgatga tttaaaatcg gttaaattta
     4561 atgataagag tggtttagaa gcagctaatt tcttaaaaga attacaagca tatgtgcctg
     4621 aagattcttt atctaaagat agtaatgaaa tgatagaaag cgtatttgga ccagggaaag
     4681 cagcatttac aataatgtta tcttctgctg caacaagtgt atttgatgaa tcattcccgg
     4741 atttaaattg gggatttgta actggactag aagataagaa agcagcaact tttggagcag
     4801 tagaccattt atctttaatg tcatctgcta aaaataaaga acttgcatac aagttaatac
     4861 aacatatgtt aagtgttgaa tcaatgacag aatttcataa agcaatacca agagcaccaa
     4921 taacaaaagg tgaaccatat caaggtgatg aaagattcaa agaaatggtg gaaaatgaca
     4981 aaaatgtata tagaccatta gtagtaggac ctcatggagt tgaaatatat gaatatttat
     5041 ggaaagaact tcaaactatg atttcaggag ataaaactcc aaaacaagcg ttagatgatg
     5101 ctgcaaaata ttcaaatgat ttattagcac aataaaagtt taaagctgta atatgttgta
     5161 aaggacttta cagattaaaa ttagcattgt atttataaat acaatgctaa tatttatatt
     5221 ggagaggata aaatggaaaa cttagttaga gagtttgaag aaaattcaaa aagaaaaaaa
     5281 acaaaattaa atattaaacc atatatgtat atattgccat tgggaataat tttagtggcg
     5341 ttttatgtga taccaataat aatgtcaata tactttagtt ttacaaagta taatattatt
     5401 agtccagcta cttttatagg tttagaaaat tataaaaaat tatttacaga tgaaacatta
     5461 aaagtatcta ttataaatac tattaaattt actgttgttg tagtaccttg ccaaactata
     5521 ttatcattga ttttggctgt ttggattaca ggaaaaggaa atagtaaaat agcttcattt
     5581 gctaaaggtg ctatatttat accagtatta tcatctatgg ttttgatagg tatggtatgg
     5641 agggctttat tgaatggaga aggttctatt atatatcagg tattaggtgc ctttggaata
     5701 gaatcatcta aacttttagg agatagtaag acagcattac ctacacttat gtttatatct
     5761 atgtggaaaa atatagggta ttttatggta atttatattt cagctataat gaatttacca
     5821 aaacactgct atgaagtagc gaaggttgat ggggctacaa aacttcaaga atttataaaa
     5881 ataactgtac ctttattgaa accaactaca ataatggttg tatttttagg gtcgatatgg
     5941 tcattacaag tatttgactt aatttatact gtgacaggtg gaggtccagg tatatctact
     6001 atgagtatag ttatgcatgc atttaactta aactttaaaa actttaattc tggatatgca
     6061 atgactgtag caaacgtatt atttttgtta atagcagtag tttcgatttt acaaaataag
     6121 cttgtaagac gagacaattc agatttttag aaaggtaggt ataatatgaa aacagcaaga
     6181 agattattaa gtgatggttt gcttttattt atagcgtgtg caagtttggt accttttata
     6241 tacatgttga taatatcatt gaagataaca tataactcat atagtttgga tatatctttt
     6301 tcaacagtaa cccttcaaaa ctatatagat atttttacta aaaaaggatt tgcacaatat
     6361 ttttttaata cagcaatagt atctttttca ggtgtattat taaatttagt atttagtaca
     6421 ttagcaggat attcttttgc gaagatggat tttaaaggta gtgataagtt atttttattt
     6481 atgataatga ctttaattat accttcccaa gttacaatga taccactata tataataatg
     6541 aaacacttag gatggataaa tagttatctt gcacttatta tgccaatacc aactgcattt
     6601 ggcgtattta taatgagaca agctatttta ggagtaccaa aagagttatt agaatcagca
     6661 aagatagatg gttgttcgga ttttagaatt ttaatacaaa tagtgttgcc tttaattaaa
     6721 ccagcattaa ttacactagc aatatttact tttatgggag catggaacga gtttatgtgg
     6781 cctcttatag ctacaactaa agatacaatg agaacattaa cagttggatt atctactctt
     6841 aagacattcc agataactaa ttatggacag atgatggcag gggctacaat aacattttta
     6901 cctccattta ttttctattt gattttacag agtaaatttg ttgaaggtgt gtctttgtct
     6961 ggtataaaag gttaaatagt ctaatttaat aatatataaa gaaacttata taaatatgga
     7021 ggaatttaaa ctatggaaat ttcatatgta ctgaaagatt gcacattcaa acacaataaa
     7081 tactcagttg tagaagctga aacttggaaa gataaggatt tggatattgt agtagctaaa
     7141 ggtgaaaaat ttgcatttca aattatgtta aaagcaacag aagaatttaa ttgtacaatt
     7201 gataaaagta gtgctatatc atggaaaggc ctgggaaata gagtaaggtt agcattaaat
     7261 atgcctaata gtttagaaaa taattttagt ataaatatat taggatatgt tcaagatgat
     7321 acaaaggcat ttgtgaatga tgctatttta agggataaag atgtgttagt agagcaatat
     7381 ttgcctcaaa cattttggat tgaaggtcaa gtaccagaag attttgaaga aaataacctt
     7441 gatataggta ttgatatatt taaaagcttt ggatatgaag acgaagaaaa agtttgtaca
     7501 attgatgttc ctgtaaaagt aagaaatgtt gtgctaaagc ctttagatga aagcaagttc
     7561 tttttagatt tatggcaaca tccaagctgt ttagctagaa tgtataaagt tgagttatgg
     7621 tctgatatac attttgaaat agtcgataac tatttaaaag aattagcatc tttaggagaa
     7681 aaagttgcaa cagttatagt ttcagattat ccatgggcag ggcaaagttg ttataaagtt
     7741 tataaaaatc catcaaactt atatgaatat aacatggtaa gtgtatcaaa aggattggat
     7801 ggaaagatta aatgtaactt tgagagtatg gataggtata taagcatagc tgataagtat
     7861 aaaatggcta aggagataga tttatttggt ctattaggta attggtgtgc tggtgagttt
     7921 ggaaatcctg tagaaggtta taaggaccct ataagagtaa gatattttga tgaaaaggat
     7981 aaagtattta aatttataaa caatacaaat gatttaaaag aatatatagg attagtatta
     8041 aatcatttaa tagagtgtgg attatgggac agagtaagga ttatagctga tgaaccaaat
     8101 aatccagaag tagtcaaaga gtgtatagaa tttataaatt ctactgtaag cactcatcaa
     8161 gttaaatata aatcagcaac tcacgaccaa aactttttag acagagctaa agatgaaatt
     8221 gatgatatgt caataaattt aaaacttact atacaaaatt ataaagatat agaaagtctt
     8281 aagaaaaaaa tcaatgacaa gggtgggata ttgacttggt ttgtatgctg ttttccagag
     8341 aaaccaaata gttttttaag ttctcctttt gtagaaaata gaataatagg atggtatact
     8401 tattactttg gtcttgatgg atttttaaga tgggactata atttatggac agaagaccct
     8461 tggaaagatt caagttacaa attccctatt tggaaagctg gagatatgtt ctttgtttat
     8521 cctggaaaag atttaaagcc agttagaagt gtcagaatgg agaatttaag atttggaata
     8581 caggactttg agttatttac aatgttagaa aaagaaaagg gaagagagta tatagaagtt
     8641 gagcttatgc aagaattatt aaataaaaaa gaaaatgctg aaattaaagg ttttggtgac
     8701 atagaactag gatattcact tgataattgg ggatatgata aagttaaaaa atatgtatta
     8761 gagttgttag acagagtata aaaaatataa gagtgtctca aaatgaactt tttagttcat
     8821 gaggcactct ttttgtatga aatcaatata gtttcattgt ttcaacaatg aaaaatagga
     8881 ttatttctat tctaagacag ccctttagtt ttttagttgt attcaatgtt ttaaaactaa
     8941 ctataaacgc tataaagttt ataaatgaca ataattatat ataacatgat gtactttaat
     9001 ttgctataat agggattgaa taatattata tggaagataa cattgtttgg ggggattaat
     9061 ataaaaagaa taggtattat tataatgttt tttttaagta tatcttttat tggattttat
     9121 cttgtaataa gagataacag tgatacagtt aagatgcaac gagggataaa tataggtaat
     9181 gcactagaat cacctaagga ttttccgtgg gatgtaaaaa tgtcaaataa gttttttgat
     9241 gatataaaag atgcaggttt tgacacagta cgtataccag taaggttttc tgattatacg
     9301 tcagattctg ataattttaa aattgatgaa gaatttttta aaaagattga taaatatgta
     9361 gattatgcat tggataaaga cttaatagtt gtgttggatt tacaccattt tgaagaaatt
     9421 atgaaagaac caagagttca taaagaaaag tttttaaaaa tatggcaaca gatagctaat
     9481 aggtatcaaa aatatgataa aaaattggta tttgaattat taaatgaacc taaagaaaat
     9541 ttatattcac agttactaaa cgaatacatt gaagaagcaa taaagataat tagaaaaact
     9601 aaccctaaaa gaactattat agtaggacca tataatttct atcaaattga ttatttgaat
     9661 gaattaaata ttcctaaaga ttctaatata gtagtttcct ttcactatta cgagccaaat
     9721 gattttgcat ttcaaggaaa tatatatcat aagggatttg agcacttaag caatattact
     9781 tgggaaggaa caaacgaaca aatggattat ttaaaaaaaa ggtttgatac tgtggaaaat
     9841 tgggcaaata aaaataaggt aaaaatcttc ttgggtgaat ttggaataac aaaagaggca
     9901 ccagaagctt caagaagagc atggataaaa gctgtaagag aagaagctga aaaacgaaac
     9961 ttttcatggg cttattggga gcttgcatct ggatttggta tatacaatca aattgaaggg
    10021 acttgggata gagatatatt aagtgcatta atagaaaaga ggtgatttta tgaagaaaaa
    10081 ttcaaaaaag atacttataa ctttaactat tattactaat gtcatatata tattgtggag
    10141 aattttttac acagtaccta aagaagaagg gaagtttgcc ttaatatgtg ccataatact
    10201 tctttttgta gagataatgg gcatgatgga aatgtttgtg cattattatg gtatgtcaaa
    10261 tattgagtac cctgaaaaac caatcataag tgaagaactt tatccacatg tagatgtatt
    10321 cattgcaaca tataatgaat ctgttgattt ggtgagaaaa actgtaaatg ggtgtattca
    10381 tatgcagtat ccagataaga aaaaggtaca tatatacata tgtgatgatg gaaatcgtga
    10441 agaaatgtgt attctagcag aaaaaatggg tgtaaattac ataactagaa ctgaaagaga
    10501 aggagcaaaa gctggaaatt taaataatgc aatgcaacat acaaattccc ctttgattgc
    10561 tacatttgat gcagatatga taccaatgca tgacttttta attgctacag taccatactt
    10621 tttgaaaaat gagcaagcta aaaaagatgg agaaaaagag gagtatgaaa aggttggttt
    10681 tgtgcaaact ccacagagtt tttataatcc agacttgttt caatttaatc tgcactctga
    10741 aggaaggatt ccaaatgagc aagattattt ttacagagac attcaattgg ctagaaatag
    10801 gacaaattct gtaatttatg gtggtagtaa tacagttatt tcaagggaag cacttgaaga
    10861 agttgatgga ttttatactt attctattac agaagatttt gcaacaggta tcttaattca
    10921 aagtaagggg tatagatgtt atgctattcc agaagtacat gcatcaggtt tatctcctac
    10981 agatttaaaa agtcttatta agcaacgtga aagatgggca cgtggatgta tacaaactgg
    11041 tagacgtcta aatattttgt ttaggagagg tttaggtttt tggcagaaaa taagttatat
    11101 ttcttcaatt acttattggt atgcaagtat aaaacgcttt gtatatataa tggcacctat
    11161 tttattttct gtgtttaatg tgattgtagt aaaatgtacg ttacttcaag tattggtatt
    11221 ttggttgcca atgtatattt taagtagttt atctcttaaa atattttctc aaaatataag
    11281 aaatactaga tggaccaata tatatgaaac tataatgttt cagtctttaa tgccagcagt
    11341 aatacttgaa acgtttgcaa tatctaaaaa taaattttca gtaacaaata agagtaaatt
    11401 agaagaaaat agaatgtata agtttttaca gggaatacct tattttattt acatggtctt
    11461 atctatcata ggaattttaa aaatgtttgt agcaatattt aaaatgagtt caatgacata
    11521 ttcagttgta ttattttggt tgattggaaa cctttttaac cttgttatgg ctacattatt
    11581 tatatcaggg agacagcagt taagaaagtc tgagcgttat attgctgaaa ttgattttaa
    11641 gttaaagcaa aattcttatg ttctttcttc aaaaacaatt gatatatcag aaaatgggtt
    11701 tgcatttttg ctagaaaatc cagaatatat ttccccagaa gaagagtttg aggtagagtt
    11761 tagagaaaaa tctggaaatg aaatgtatat agctaatatg aaagcaaaga ttgttaatgt
    11821 tgtggaagta aattcaaagt ggaaatatgc agcttatatt acacatattg aagatagtga
    11881 aatagataat tggatgtgta ttgttcacga tagaatacct actttaccaa tgacaatatc
    11941 taatcaacta ggtttctttg atgatttgca aattaatgta aaaaaacgta ttgaaaaaac
    12001 tagaacatta tcacgaagaa gtccaagaat caatatgaat tttcagatgg atataaaaaa
    12061 tacaggtaaa ttaagaatag tgaattttaa ttatcaatat gtattattaa attttgagaa
    12121 taaaagtatt tatcctaaag aaatagcatt ggaaattaat gaaaatattg tgttagaatg
    12181 tgatttgtgt gagggtaaaa ttgatgaaag aggtatctta tataaagtaa ataacattga
    12241 cagcataatg caaaatttct ttttaagaga tgaaatgatg gattggatat tacaaaataa
    12301 gaaaattctt gattcaaagc ctagtgaaaa gaaggaaaaa agtatagatg agtttgaacc
    12361 catggaatat atttaggaga gatgaaatga agactttaaa agtgtttttt tgttctacaa
    12421 aatatcttat tttggtgttt atttttttta taaatactac ttttataagt tcagcaacaa
    12481 gtgataaaat tttagattta tcctttaaaa agatagagac tgacttaagt tctaagatta
    12541 catatgagga tacaggtgta aaaatagaaa cggatagttc taaaagcgat aaggaacgtt
    12601 atttatatat ttaccaaaat ataaaagaaa attggagcat gtataataat ttttatattg
    12661 aaattcaaaa taaaaataaa agttctcaga gaataaattt aagcatacaa agtaaaaata
    12721 tgcttgaatt tagattaaaa gaaggtagtg aagtattttt agaaggtaaa aatataatat
    12781 attcagataa aataaaagaa ggatgcatag aagtaccagg tgaatttgaa ggcaaaattt
    12841 atgtgaactt taatagcctt ataaatgagg aaagtaatgt tgtgctggac tcaaatatgc
    12901 tttcaaacat tgttagttgg ggaattacgt ttattccatc tgatgaagaa cataatattg
    12961 ttattataaa aaagatatct ttattgtctg aagagaaatt aagattttta aataatatta
    13021 aaataattgg cgatgaagaa gtacaaatac cagtattggg tcaaagtata agtcagtatg
    13081 aggtattagg tcttaaaagt gattctaaaa ttaagtactc tcttatggga aaacaagata
    13141 atgtgagtat atctcaaaac ggtaaattaa cattaagtaa taaagccaaa cctggacaaa
    13201 ttattttaca agttaatgtt gatgataagt ttaaaattgg aaagaaaata acattaactg
    13261 aatcttggag tattaataaa aaagataagg atggtgttcc atatacatta gtatctcctg
    13321 agcaatcacc aacagtacaa gatatgaaaa aaataaattt tatgaataat atcataacgt
    13381 ttgttcgaat tttatttgta tctctagtaa taatatgctt tggaatatat ttatattgga
    13441 aaaaatgttc aaaaactaag taaagagagg aggttagatt gtgttatttt caagtttaat
    13501 ttttttattt tattttttac ctataacttt ggttttatat tatgtattta ggtttaaccg
    13561 aacgatacag aacatgatat tgcttgctgt tagtttattt ttttatgctt ggggagagcc
    13621 aaaatttgtt gttatcatga tagtttccat aataatgaac tatatatttg gtttactggt
    13681 agatagatat agggaaagta aaataaaagt aaaagttttt ttagttttga tgtgtgcata
    13741 caatataggt gttttattta tatttaaata tctagctttt gcgctaagaa atattagtga
    13801 acttattagt actgaattga ctatacctaa tattatttta cctataggaa tttcattttt
    13861 tacatttcaa ggaatgtctt atgttataga tgtatatcgt agacatggag aagtccaaaa
    13921 gaatcctttt tatgtgggac tgtatatagc atttttccca caattaatag caggtcctat
    13981 agttagatat gagagtgtgg cagaacaaat tctcaataga aaagaaactt ggaataaatt
    14041 ttctattggt acttgcaggt tcataacagg tctaggtaaa aaagtattaa tttcaaataa
    14101 catggctata gtagcagact atatttacac tatgaatagt caaggagaaa tagctgcatc
    14161 acttgcatgg cttggttcaa tagcctatac tctgcaaata ttctttgatt tttctgctta
    14221 ttcagatatg gctataggct taggtcttat gtttggtttt aaatttgaag agaactttaa
    14281 ttatccatat atatcaaaat caattagtga gttttggaga agatggcaca tttctttggg
    14341 aatgtggttt aagagctata tatactttcc gcttggaggt tctagagtag caaataaaga
    14401 tattatgatt agaaatatgt ttatagtgtg gttattcact ggaatatggc atggagcaga
    14461 atggacattt gtaatttggg ggattttaaa ctttgttttc ctaattatag agcgatttat
    14521 aatgtttgaa aagattgaaa atcacaattt tataaaacat atttatgctt tattagtagt
    14581 taattttgga tgggtattgt ttaggtcacc taatttaaaa gaagcatata attattttaa
    14641 agctatgttt ggaggcaatg gagctatatg gagtgattat acatatatgt ttttaaaaga
    14701 atactgggtt ttctttatat ttgcatttat ttttagtgta cctattgcaa agaaaatcaa
    14761 taagtttgtt gttgaacaag ctaaatatag tatgatattt aacgtatttt atccaatctc
    14821 agctatttta ttgtttttta tttctgtgac atatttagta actggaagct ataatccatt
    14881 tatttatttt aatttttagt tgggaggaaa agtatgaata gattttttaa agtaagatta
    14941 ataactgcaa ttatgttctt aattatttta ttcgctttct ctatctttaa tgtttgttat
    15001 tctggaaaag atacgataca ggaaataaaa aattcaatag ctgaaaaaag tagtttaaaa
    15061 gatacaatat catctattga taatacagtg aatgacaaag taatatacaa aaatacgttc
    15121 attgaaactt atggctattt acaaaaatta atgggtaaaa atgagttttc aaaatttagt
    15181 gttgtaaaag atacttctgg aaagatgcat tatacatatt ttgctaaagc tccaaatcca
    15241 gttggtgtga tagcagatag ggtaagaaaa ttttctgatg aaatggaaaa gcaaaacact
    15301 aaattggttt acctaatgac tccagataag tatataaaag gagtgacaaa atttccaaaa
    15361 ggaatacctt attcttatag taatgagaca gcagataatt ttttaaatca actaaaaaag
    15421 tataatgtgg actatattga ttttagagaa aatattttaa agagtggtat tccaaaagat
    15481 gatttatttt ttaaaacaga ccatcactgg aaagtagaaa cttctttttg ggcatttgga
    15541 gaattagttg agcaacttaa taaaaaatac aatatgaatt tagatgaaaa tcattattat
    15601 agagataagg acaattataa ttcaattgta tatcctaagt catttcttgg ttctatggga
    15661 agaaagactg gtatcttata tggtggtata gatgatttta cattaattta tcctaaattt
    15721 aagactaatt atacttatta tacagattct aaatctcaaa aatttgaatt aaaaggaagg
    15781 tttgaagaga gtttaatatt atcatatcct tttaatgcag accttgattt aatggatggt
    15841 caatcagata agtattttac atatttattg gggaacagac cattagttaa aataaaaaat
    15901 atagaaaatc cagatggatt aaaagtgctg tttgttaaag attctctaat tgtaccaaca
    15961 gcagcatttt tttcctctgt ttgttcatct atagatatga tagaccctag atattatgat
    16021 ggagatatac tagaatatgc aaaatcccat gactatgact ttgtttttat atctgtatat
    16081 ccccaaaatc ttacaaaaga attttttccg ttttgtgagt aaatttctaa aaaagttttc
    16141 tgataaaata aatggctaac tggtaaaaag ttagccattt attttgagtg ttattctaag
    16201 aaatattttt tttactaaat acttctttat ctatttttcc aagtgatttt cctacagtaa
    16261 ttgatgatac catagcacca ttaacattta tcatagtacg tcccatatct agtatagggt
    16321 ctattgcaag tataccacca actaatggaa aataagaacc aagaccaact ccagagataa
    16381 caactgaaac ggccattgta gcagttcctg gaagaccagc tattccaaac gaactaattg
    16441 ttataacaat taacaacata acataaaagc tcatatccat gtttactcca gccatattgg
    16501 caagtgttac agccattaaa gcaggatata tacctgcaca accattcata cccatatttg
    16561 cacctaaact tgctgtaaag cttgatacac cctcatcaac tccgtgattt tgtactagac
    16621 tttctatcgt tacaggcaat gttcctaaac tagaacgtga agtaaatgcc agaagtaaag
    16681 cttcagttga attttttata taagtaatgg gatttagacc atttaaagtt ataaaaatta
    16741 aatgtataat aaataatatt gcaactgata tataaagagc taatataaac tgtaaaacag
    16801 atactattga actaatacct tgtgaagtta ttgtatttgc aagcagagca accacagcat
    16861 aaggcataaa tttaataaca gtcatagaca cacttacaat tattttgtaa gatgcttcta
    16921 taaaatctat aaatggtttt attgtctcaa aatgtttttt acttaatctc tttattgagg
    16981 tagctataaa tgtagcaaat attattgtag ctacaatatt tccatttgcc atagccatta
    17041 caggattaga tggtagtaat cctcttaaag tatccacaag agagtttatt tctttaagtt
    17101 cttgattttc aactaaagta ggcatattag ctcctacacc taacttcatt atatttgcaa
    17161 cgataattcc aacaattgca gctatagcag tagtagcaag aagcatacct aaagatttaa
    17221 atgtcagagt tccaagattg ttatctttca tatttataat tacttttata atggataaga
    17281 aaactaaagg tactactaac atttttaata agtccataaa tccagaacca aataggctat
    17341 accacttact tacttcttgt agccaagtga cttgagttgt atcattagga aaaccagcaa
    17401 aagcttgtat tatgattccc aatatgagtc ctagtactgt agcatatatt gttctcaatg
    17461 aaaattttat ttttttcttt tcaaattgtc taacaataaa gaacgtacct agaagtaata
    17521 ttatgaaaaa aattgtttta aaatctgtaa tcataagaaa ttgtgataaa aatgaacttt
    17581 ccaatatttt tctcctttta tttaaaaata aatttttcta agtttaaatg atatcaatat
    17641 attaaaaaaa tgtcaatatt atatcacaat ttacttaaat agagtaaaac aagttgattt
    17701 tgaaaaatgt gattaagtac agaaaaatag ggtataataa atgtttaaag aatttgaatt
    17761 gtggtaagaa aataaaaaat agcttttata agatttgatt tcaaattaaa atatgttaaa
    17821 taaataacta aaaattatta taaaaaatgt tttcatagaa tatatatcaa atgaaaagct
    17881 taaaataagt gaagaaatta actagacatc aaaggagaga taaaatgaga gtaataataa
    17941 ttggtggtgt tgcagctggt atgagtgctg cagcaaaatt aaaaagaata aaacctgagt
    18001 atgaagttgt tgtttatgaa aaaactgaaa tagtatcttt tggtgcttgt ggattaccat
    18061 actttgttgg tggatttttt aatgatgctg atgaattatt agcaagaaca ccagagaaac
    18121 ttagagaagc tggaattgat ttaaatatat ttagagaagt cgttgaggtt gatagtgaat
    18181 ctaagaaaat aaaagtaaaa aacataaaaa cagatgaaat atatgaagat tactatgata
    18241 aattgatgat agcaactgga gcaagaagta ttatgcctcc tataaaaaac ataaaattga
    18301 agaatgtttc tacattaaaa agtttatatg atggagaata tctaaaaaaa cttttaagta
    18361 atgaagataa taaaagagtg acaataatag gagctggttt tatagggtta gaagcagttg
    18421 aggcatgtaa gaaattaggt aaagatgtag atgtaattca gttagaagat agaatattgc
    18481 cacaagtatt tgataaggaa atgacggatg tattagaaga agaaataaat agacataatg
    18541 ttaatttgca cttagatgaa atggttgtag aactttgtgg agaagataaa gtagaaaaag
    18601 ttataacaaa caaaggggaa atagatacag atgtagtaat aattgctact ggcgtgagac
    18661 ctaataccga gtttttgtca aatactaata taaaaatgct aaaaaatgga gctatagtag
    18721 ttgatgagta tggaagaact tctgtagaag atatatactc tgctggagat tgtgcaacta
    18781 taaagaatat agtaagtaat gaaaatgtat atgttccttt agctactgga gctaataaat
    18841 tgggtaggat agtaggagaa aacctagcag gaagagaagt atcttatcaa ggttcactat
    18901 cttcaagctg tataaaaatt atggatatgg aggcagcatc aactggaatt acagaaaagc
    18961 aagctaaaga tttaggcata aatgtcaaat ctaaatttat ttctgattat aatcaaactc
    19021 attattatcc aggaagaaat aaaatatatg taaagcttat ttatgatgca gatacaaaag
    19081 ttattttagg cggacaagtg gctgggttta aggatgctgt ccaaagagca aatgtattgg
    19141 cagctgctat ctttggaaaa atgaccacaa atcaacttgg aatgttagat ttatgttatg
    19201 ctccaccatt tgcaagaaca tgggatgttt taaatgtagc tggaaatgta tctaaataat
    19261 atttagatta tagctaatat agttgacaag caattaaggg aatgaattta cctaaactat
    19321 ttttatcatg gtaaaattca ttcctaaatt tttattccaa atttttattc caaattttta
    19381 gaaataagga ttccattaaa ttattcatca aaatttaaac gcaagcttaa tctatcttct
    19441 ccaaggatag tattttcaaa aacattagta gcattttcta aatacatact aggtatgtct
    19501 aaagaaggac taaaatgagt cagtaaaagt tgtttgacat ttccaagttt tgcaagatta
    19561 gcagcttctc taaaagtcat atgtttgttt ctaacagctt ttgatatatc taaatcatca
    19621 ccatacatgg cttcacatat aaataaatca ctatctttta tgaaatctgg tattgattct
    19681 ataggtcttg tatcggttgt aagacttatc ttaactccct ttctcaattc tcctaagacc
    19741 atatctggag tgtattgttt tgaatctaaa actatatttt gaccttcttg gagtttgttc
    19801 cataatattt taggaacttc gtttttagtt gccttatcta tatcaaattt agggtttctt
    19861 ctaaaattaa aactgtatcc taaacactct atagagtgtt ctaaactgat tgttgaaatt
    19921 tctaaatttc ttaaaacttt attatctaaa gaaaaattgc cttgagggtt ttctataatt
    19981 tttaaagtgt atggtacata ttctactaaa tttctcatag aacgtataca atcgactatt
    20041 ccaactggac caactatagt taaatcactt gtacgaccac tatttccaat tgttgataaa
    20101 agtcctaaaa gtccaaatat atggtcacca tgtaaatggg ttatacaaat caagtctata
    20161 tctttaaagc cacatttttt tagcttcata gatacctgag taccttcacc acagtcaatt
    20221 agtatttttc tacctttata gtttataaat acagaggata gaaatctgtt tggcataggt
    20281 acatttccac cacatccaag taaagttaaa tctatcattt tttccccttt ctaaaattaa
    20341 cacaaatctg ttgtttgttt ttattatgat atcctattat aattatttta acattaaata
    20401 taacaataaa tgtgtatttg agtcaagaaa tattgtcaaa taaagttttt atatagaaat
    20461 gtataaaaat ttggaaaaca aaaagtgaaa attatattta ggagcattta aaggaggaaa
    20521 atttaatgaa agtattaaag aaaattacta ttttgtcatt aattacatta accttagttg
    20581 gttgtagtaa cggagaagat aaaaaagtgg ttgaaggttc taagaaaatt caaaattcta
    20641 aaaaagatga acagcctata atagtacata aagatgcaaa tatattgaaa gataggtatg
    20701 agccaccaaa aggatttaaa agagttgatg tagaaaaagg tagttttgaa tcatttctta
    20761 ggaatactaa gctaaaaaat tatggagaga aagtaaagta ttatgatgga agaactaagg
    20821 aatcaaaagg tatttatgat agtgtatttg atgttgatat tggcaataga gatttgcatc
    20881 aatgtgcaga tgcaattatg cttatgagag cagaatactt gtatcagaat aaactatatg
    20941 atgaaataag ttttgatttt gttgatggtt ttaaggcgaa gtattcaaaa tgggcacaag
    21001 gatatagaat ttcagtaaaa gatagtggtt caagctggta taaagcaact gaatattcaa
    21061 catcttatga gagttttaga aagtttatgg atatagtgtt tgcatattca ggaacgttat
    21121 ctcttgaaaa agaattggag cctgtaaaag ttgaggatat gaaaatagga gatgtgttta
    21181 tagttggtgg aagtccagga catgcaagta taattatgga tatggcagaa aatgaaaaga
    21241 ctggtgaaaa ggtatttatg atagcccaaa gctatatgcc tgcacaacaa acgcaacttc
    21301 ttattaatcg taaaaatcca aatttgagtc cttggtatag tttagatttt gaaggtgatt
    21361 tgacaatacc tcaatggact tttaaaagag accagttgaa aagattttaa aataataatt
    21421 ttatataata aaagaaaaat atagatgtga aaaaatgtaa ttagattaaa actaattgga
    21481 tatggacaaa attaaattga tagataaata ttaaaaatta cactaattaa tcttactata
    21541 gtttaatatt tatctaaaaa gttttatgta aaatataaat tttatattaa agctaaaact
    21601 aatttgagga ggctaattta tattgaagat tagaaggtat ttaattttgg taattataat
    21661 tctaattaca acaagtcaga gttttatttc ttatgggcta gagcgatttg aagaaataac
    21721 catttttcac actaatgata tacatggaag atatgctgaa ggtgatgacc atatacaaat
    21781 aggaaatcta gccacattga aaaaagaaac tccaaactca attttagtag atgcaggaga
    21841 ttgtttgcat ggacttccaa tagtaaatat ggatagaggg aaaagtgcaa ttgaattaat
    21901 taaatgtgct ggatatgact atattactcc tggaaatcat gactttaatt atggaaaaga
    21961 tagactgttt gagttatcta aaagtgctaa tttaggagag aatactttaa aatttttatc
    22021 atcaaatatt tttgaaaatg gaaaaaaagt ttttgatagt aatgatataa aagaaataga
    22081 tggaataaaa ataggatttt ttggactctc aacccaggaa acaaagagca aaactggatt
    22141 taaaaatgtg gaaggattag agtttaaaaa tcctatagaa agtgcaacag aacaagtaaa
    22201 tgaattaaaa ggaaagggtg ccaatgtaat agttgcaata tgtcatattg gtacaaatag
    22261 tttaagtaag ccaaatagta tagatatagc aaatgaggtt caaggaattg atttgattat
    22321 tgatggacac agccacacta agtttgaaaa tggtaaacaa gtgggtgata cattgattgt
    22381 aagtgcagga caatatttag aaaatattgg cgagataaaa ctaactttgg atactaatga
    22441 tgtagaaaat ataaaaatag aaaataaatc agttagatta attggaaaag aagaagcatt
    22501 aaagtataag cttgactccg ctgtaagtaa aaaggttgat gaaataaaag aacaacaaga
    22561 aaaaatatta gataaagtta taggggtaac tacaaatact ctagatggtt catatgaaaa
    22621 tgtaaggaca aaagaaacta atttgggtaa tttaataagt gacattttac tagataaaac
    22681 taaggctgat atttctttat ttaatggagg gaatattcga gatacgatag aaaaaggcaa
    22741 tataacaaga agagatattg tagatgtatt tccttttagc aatactatag ttaccaaaga
    22801 acttacagga gcacagatta aagatgtatt ggagcatgga gtaaaacttt atccagaaaa
    22861 aagttcagcc tttttgcaag tgggaggaat ttcatattac tttaatccta aacaaaaaga
    22921 aggcgaaaaa ataacaaata ttcaaaaaga aggaaagcca ttagatttaa ataaaaagta
    22981 tgtagttgca acgaatgatt atatagcatc aggtggagat gaatttcctt gtttttcaaa
    23041 agagccagta ctaaaggaat ttggaaattt agagagtgca gtcattgaat atatagagta
    23101 caaaaaagaa atatcaaaaa atgtagatgg aagaattggt attaaatcta aagatgagtt
    23161 aataagcaag aatcatgaga gtgatttgat attaagtgaa aatgaaaaaa atatcaatga
    23221 taatgaagag aatctatcta ataatataaa aagctctgat agtgataaaa ataaaagctt
    23281 agataaaaca agtgctagag aaagttctaa tctaggaata tctaaaagag aagctaaaga
    23341 aaaatctcct aaaacaggag atttaggttt ttcaaatagt ataattatat ttatagtttc
    23401 aagtacattg atatgtttat tgaattttaa tcaaaaagag ttaaaggata aaaagtcaaa
    23461 ataaaaatta atgagcaaaa attagtagat agtaatttaa ttttagataa tagtaaacag
    23521 caaaggaaat tagttatata aatactaatt tcctttgttt tatgttttaa catgattact
    23581 tttaaataaa attgtatttt atgaaaaata attacactaa atggcatagt attatgggga
    23641 tttttagttt ttattcaagt aaatgaaatc atattaacaa cttctgatat atttacaaat
    23701 tgataaaaaa atgattttat tagtatgata taatttagct agtatatatg atgatggagg
    23761 atatagggat gaataatata ttacttttgg aagatgacaa atctttaaat agaggaatta
    23821 gttttaaatt aaaaaaagaa ggatacaatg tttttagtgc atttggtata gaagaagcaa
    23881 aaaatatttt cgcaaaagaa gagatatgct taattatttc cgatataggt ctacctgatg
    23941 gtagtggttt tgacttttgt gaggagatta gaaagaaaag tgatgtttac ataataatgt
    24001 tgacagctct tgatgaagag gtggatattg tcacaggata tgatttaggt gcagatgatt
    24061 atatcacaaa gccttttagc ttgatggtat taatatcaaa agtgaatgcg cttatgaaaa
    24121 gagtaaatac agtaaaaaat tatactctat tagtttgtga tgatttattc ttttattata
    24181 tagaaaataa attaattata agaacagatg ataaggaaga agagataatt ttaagtaaga
    24241 cagagacaaa actattaaaa tatttgatgg aaaattctat gcagacattg actaaagagc
    24301 aactgttaga atctttatgg gatagtagtg gtaattttgt agatgataat acgattgcag
    24361 taaatataag aagacttaga caaaaggttg aaaaaaatcc atctgaacct aaatatataa
    24421 aaacagtaag aggggttgga tatatgtggg gagaaaggag tataaaaaaa tgctaaaaaa
    24481 tatgaacctc aaagatggtt taagtgtgaa agatgattat ataatgagaa gagttattgt
    24541 atattctgtt ttatctgtac taatagtaac ccttgtattt atactttttg aatatagcag
    24601 attacataaa ttgtatgaac atcaaataaa aaacactcaa aatattgctg gaatattgat
    24661 tgaaaaatat cctaatgatg aaatagatat agtaaattct atttataatt ctgattatag
    24721 taaggtgtct actggagaaa aggcatttaa gaaatttggc tatggattgg aaaataaaat
    24781 gtcaaatgat aaaaatttta gcttatactt aaaatctttt tttaaggaat cattttttat
    24841 ttttttaatg atgtttatag tagttatagg tataatatat tattttataa gatacataaa
    24901 taaaagattg agtaaaattt attttatagt agataagatg tcacaagaaa actacttgaa
    24961 ggacactact gagtcagaag aaactggtta tctagtagaa tataatgaat actttaaaga
    25021 aggcatattt agtaagataa ataactgtct atatgagctt aatagaagtt taaagataaa
    25081 gtttattaaa ttagaaaaag aaaaagaaag tgtaaaatca ttagtaacag atatttccca
    25141 tcaattaaaa actcctttag catccttaaa attatacaat acattactta tagaagaaga
    25201 attagaagaa gatgaagcca acgagttctt attaaccaat aaggcttcta taaataaatt
    25261 agaaaattta ataaattctt tagtgaacat atcaaggtta gaaattagca tgataaacat
    25321 aaaaaaagaa gataatgata taaaaaatac tattctaaat gcagtaaaaa gtgttacccc
    25381 taaggctaag agcaaaagta taacattaaa tttaaatgaa tttaacagta gaattatacc
    25441 acatgataaa aagtggactg aggagagtat ttttaatgta ttagacaatg ctgtaaagta
    25501 tacacaggta aatggagaaa taaatatatc tgtagaagaa actgctaatt tctttaaaat
    25561 tataatagag gataatggca tagggattga aaaaaatgag tttaataata tatttaaacg
    25621 tttttataga ggttctgctg atgaaattga atctgtagaa ggtagtgggg taggattgta
    25681 tttaagtaga aagattttag aagaacaagg tggaaatatt atagtttctt caaaagtagg
    25741 aatagggagc aagttttctt tgtttcttac aactatgtaa tattaaatga aaggaaaatg
    25801 taagcctcta catttattat ataagtataa acagctccag aaataaaaaa ttaataaaat
    25861 atggagtaat ataacttaga atgagaggat aattttatga aaatactata tactgaaaat
    25921 ttatcaaagc attatggaaa aggagaaagc ttagtaagag ctttggacaa tgttgactta
    25981 gaaataaatg aaggtgaatt tgttgcaata ataggaaaat caggttctgg aaaaagtaca
    26041 cttttgcata tgattggagg tcttgatata cctacatctg ggaaggtgta tatagataat
    26101 aaaaatatat ttacattaaa agaagaagaa cttgctgtat ttagaagaag aaaaataggg
    26161 tttatatttc aaagctataa tttaattcca tctcttaatg tatgggaaaa tgtagtgttg
    26221 ccaatcggtt tagatggtag agaagtagat gaatctttta taaaagaact tttaaaatca
    26281 ttaggacttg aaaataaaca cgacgtttta ccaaatacat tatcaggtgg tcaacaacaa
    26341 agggtggcaa tagcaagagc attagctaca agaccagcta taatacttgc tgatgaacca
    26401 actggaaacc tagattctaa aacgtctgat gaggttatga gtatattaaa atctatgtct
    26461 aagaagtaca gtcaaactct agttatgata actcatgatg acagtatagc ccaaatggct
    26521 gatagagtta tattcataga agatggcagg gtgtcaaagg ttggtgataa aaatgattaa
    26581 tactactaaa atagcaaaaa gtaatttaaa gcaaaataaa tcaaaaagta ttctaataat
    26641 aattactata atactttcaa ccttaatgct ttcttctatt ggaatttata ttgttgatgc
    26701 aggagcatat caaaaagaaa atactataaa gtattcaggc aattatcaag gtatattagc
    26761 aaatgtagat gaaaaacagg ctgatatatt gagtaatcat gcagatgttg aattaactgg
    26821 tgaaatgaat ggagtaggtg ttgaaaaact ggaagatgat tcaaatattt ctctagcata
    26881 catgaatgaa gatgctttga aattaaatag ttttgaattt atcaaaggaa aattgccatc
    26941 aaaagagaat gaaattgtgt tagatagtgg agctttaaag gcacttggtt ataaaaataa
    27001 agatttaggt gaaaagataa aaatatctta tgatgactat aaaaatgata aaaaaattga
    27061 aaaagagttc attataagtg gaatcttaaa aactagcgaa atatctgaag caggtaaata
    27121 ttattatgct attatatcag aatcatatat gagaaatact agagatatgt cacaagaaga
    27181 ttttaatatt tatgtgaaat ttaatgataa aagtaattta tcaatagagc aagcaaaaga
    27241 aaaattagat aaaattgcta atgatatagg actggatact attaatactg ctgtaaatga
    27301 aaattatata aatgctttaa aaccagatat ggaaacgatt atgggtggag tttttgtagg
    27361 gttagtaatt gtattatcta gtattttagt aatatacaat atattttata tttcaatagt
    27421 tacaaaggtt caagaatttg gaaaacttag agcaattggt gcaactaaga aacaaataaa
    27481 aaatatagtg tttaaagaag ggttcatatt agccggaata gctataccaa taggaataat
    27541 tttaggctat gtacttgcaa atattataat aaaatcattt atggatatag atgtaaaatc
    27601 atcacgatta ccagttatat tatcggttgt ggtaataagc tttatatctg ttgttttatc
    27661 acttttaaaa ccaatgaaag tagcatcaaa agtatccatt gttgacgcag taagatatac
    27721 aggaaataaa ataagtaata agagtaagag aaaaggatat aaaaatataa atctaaagag
    27781 attatcacat gccaatttag aaagaaataa aaaacgtact tacatgacat tggcatcact
    27841 tatacttagt ggaactatat ttataacagt atcaactgcc ttagaaagtt ttgatgctga
    27901 gaaaatggca agagaacact ttccttatga tatagaagtt agactatctg gttatgaaat
    27961 gaacagtgat aaaaatccta aagataattt gaatatttta caaatggata atcctctaag
    28021 taaagatttt tttaatcaaa taaagaacat ggaaggaatt aaaagaatag aatctgcaag
    28081 aagtgtaaaa attggtatgg aggactatga tgttgaattt aagtatgacc ttttacaaag
    28141 tataaatgaa aatgatgtaa aatcattaaa caagaatata atagatggaa aaataaatct
    28201 tgaaagactt caaactggag atgaaatagt aattactcat gttgatacag caaaagaaat
    28261 gggagtaaaa gcaggagata aaataagatt aactttatat gatggagata aaaagataaa
    28321 aaaagaattt aaagttcaag caatagctat gggggttcca agttttggta tagggaaaga
    28381 ttttatagat agaactttga aatacgattc aactagtagc ttgggaatat atacagaaga
    28441 aggaaagtat caagaaatca aagatagtat caagaagatt gctaaaaata atggattttt
    28501 agagactgat tttatagata gtagaattga gtcaaataag gctactattt catttataaa
    28561 gataatggga tacacgctaa caggcataat aggtgtgatt ggatttatga atcttgtcaa
    28621 cacaatgata actagcatag ttactagaaa aaaagaactt ggtatgcttc aagctattgg
    28681 tcttactaat aaacaattag tgaaaatgct taattcagag gcaatatatt acacttctgg
    28741 aatgatgata ggaagtattc tatttggagg tatattaggg tatattgctg ttatatttct
    28801 aaaaaagact ggattatctt atgcaacata ttctttgcca atagtaccaa tcttgttgat
    28861 gattgtgtgt attcttatag ctcaatttat aacaacttat ttgataggac gaagttttaa
    28921 taaagaatct cttattgata gagtaagata cagtgaataa aatgcaaata tttatggtta
    28981 gtttaactag caaaaaacat ataaaaaaat atagttaaag agattcataa ttaaataggt
    29041 taaagcatag tacagagcaa acaatttaaa cagatgtttg ctctgtattt tattatgtaa
    29101 tcaataatat atctaatata ctgatattat tcatgttaga aaatgtaccg gtacaattct
    29161 aaaaaagtat aaaattgtac catataaaat gaaaattttg tataataatc gtatagaaaa
    29221 taaataggag ctgatatata tgaataagaa gattaattat gcaccaggac caactgaaac
    29281 tagggaaaat gtaagattag caagagcaga aaaaacaaca aatccagata tagatattga
    29341 ttttgttgaa ttttataaaa agacatgcga gaagtttggt aatataattg gaacaaaaaa
    29401 cgatgtttac atattgagtg gtgaaggaat attaggtctt gaagcagcat gtgcatcact
    29461 tacagaaaaa ggagatagag tacttgtaat tgacaatggt atatatggag aaggttttaa
    29521 agattttgta acaatgtatg gtggggagta tgtgcttttt tcaagtgagt atactaaaag
    29581 tatagatatt gatgaattga aagcattttt agatgaggat agtaatttta aatatgcaac
    29641 agtagtgcat tgtgatactc caactggcgt attaaatgat gtaagcaaaa tatgtccatt
    29701 acttaaaaaa tatggaatat taactgtagt tgattctgta gcaggtatgg taggagaaag
    29761 attaagtgta gatgaatcta aaatagatat aatattaggt ggttcacaaa aagctatttc
    29821 tgcaccagca ggacttacta tagtcggaat aagtcaagat gcaaaaaatt gtataaaaaa
    29881 tagaaaaact gatgtaatag gtttttattg taatttaaat atatgggaag gctattatga
    29941 gaaaaaatac ttcccttata caatgccaat aagtgacata atggggcttg ataaagcact
    30001 tgataatata ttagaagaag gaatagaaaa tgtattaaat agacatgaaa agatagctta
    30061 tagtgttaga aaatctattg aggaatatgg tctagaacta tttttagaag aaggatattc
    30121 taatacagtc acagctataa aaattcctga aagtatagga gctttagaac ttactgatta
    30181 tatgcttaaa aattataata cacttgttgc aacatcacta aatcaatata tggatactat
    30241 tttaagaata ggtcatatgg gagagaatgc aaatctaaat aaaatagaac atgtactaaa
    30301 tgttttggat aaaagtttaa gtgcattagg attcaaagga aatggaaatt tgttaaattt
    30361 atttaataag tattattttt aatagatagg gggatatagt atggaagtta cagctaagca
    30421 aaaatttaca acgaaagaca tggtggaaac ctcactatta atagcattag tatttattgc
    30481 aactaaattt ataaacataa gattaccaat atctataaat ggtgggcttg tgcatttagg
    30541 aactgcaatg ttgttcatat cagcaatagt atttggaggt aaaaaaggtg ctttatcagg
    30601 ggctattggt atgtcacttt ttgatttgat atctgggtgg actttatggg caccgtttac
    30661 ctttatagtt agaggagtta tgggttattt acttggaaag attgcatggg caaatggtaa
    30721 taatgggaat aattttttaa tcaatgtaat aggaatatgt gtttcatcaa tttggatgct
    30781 atttggatat tatgtaacag aagttatact ttatggtaat tttatagtac ctcttacttc
    30841 aataccaggt aatttaatgc aagtattgat aggtcttata atagcgcttc ctatttctaa
    30901 ggtattgaaa aaatgtataa aataaatata aagtgaacta aaatttatga tagcataaat
    30961 tatactgtat aatattagga tggagtacat aattaaaaaa ttttagtata gaggttagtt
    31021 cacaatgtta tcagttacaa gatattcaat caaaaatgtt cgtttaaagc cgtgggtaaa
    31081 gtttatttgg tattttgaga caaaatcaaa tatactgtta aataataagt tacttccgac
    31141 agacagtata gatattattc tcaatctttc tgatgttatg gaatataaaa ttgaaaatca
    31201 agactatact gctagtaata tgcattttaa tggaataagg gataaacatg gatttattat
    31261 tcaacatgga aatatacgtg ttatagggat ttctttttat ccatttggtc tctatccatt
    31321 tttaaagata ccaatttcag agtttaacag acaaattgtt gacctagaag cagtatcaca
    31381 gctatttgca aaaaaattgg aagagtcatt aaatccaaca caatcagtag aaaaaattgt
    31441 tttatattta gaagaagtat tattatccat attagaagaa gatttaattt caaataaat
//
LOCUS       DAEPID010000044        31338 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.044, whole genome shotgun sequence.
ACCESSION   DAEPID010000044 DAEPID010000000
VERSION     DAEPID010000044.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 31338)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 31338)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..31338
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.044"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            112..303
                     /locus_tag="KR257_002264"
     CDS             112..303
                     /locus_tag="KR257_002264"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423633.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0030948.1"
                     /translation="MERLMELIERKFLKDVELLELEDIENVIECKMTQPYNAHYNEYL
                     VKVKNGDEVEEYFVYLKHR"
     gene            complement(392..1204)
                     /locus_tag="KR257_002265"
     CDS             complement(392..1204)
                     /locus_tag="KR257_002265"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430209.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Mrp/NBP35 family ATP-binding protein"
                     /protein_id="HBH0030949.1"
                     /translation="MADCNSCPSKGNCNSQSNCSIENNPNNKFGKIIGVMSGKGGVGK
                     STVTALLANKLNKMGYKVGILDSDITGPSIPRLMGVKNVKAYSDGSYIYPVENSNNIK
                     VMSINLMIDDENEPVVWRGPLLGGVVKQFYTDVLWEELDYLLIDMPPGTGDVALTVMQ
                     SIPISGIVMVSVPQDLVSMIVSKAVNMAKKMNINVLGVIENMSYIQCPDCSKKIKLFE
                     GESTEKFLDDLDLELLGELPMTKEIIDITHNGVTEISDDLDSILTNVVEKIK"
     gene            1626..2777
                     /locus_tag="KR257_002266"
     CDS             1626..2777
                     /locus_tag="KR257_002266"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004452985.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HBH0030950.1"
                     /translation="MELRPRSAKLEEFDKVIELINYVFRISRNHKPTMMEEFPLLLSK
                     NNIENMIIISEDDKVVSDVNYLIQDVSIQGNRLKVAAIGGVCTHPDYEKRGYSSKILD
                     KVEEKMFYDGVDIVIISGTRSLYSRRNCSLVKSFYKYTIKPEDVKIAYEIVEFDETNF
                     EKDNDLDKMIELYNQNSTRFIRTRDEFQKLLHAATIAWGPIGYKKVFIKENNNIIGYL
                     IIRTIKKEDSTVGEVAEIGLNSVNVENILKYVANKFGLESLNYKVHVKNLKDQLKCNG
                     TKSLDYQQGTMKIINFTKLCDSLRSYFSQYVDFELLKYMEFKQVENKYIIKYKEEELV
                     IENLDKLNKLFFEKNEEQYNEFKHLKNIYEFATKAFPVDFPWTANLNYQ"
     gene            2895..3533
                     /locus_tag="KR257_002267"
     CDS             2895..3533
                     /locus_tag="KR257_002267"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423639.1"
                     /note="Presence of a B(12) (cobalamin)-binding domain
                     implies dependence on cobalamin itself, in one of its
                     several forms, or in some unusual lineages, dependence on
                     a cobalamin-like analog; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cobalamin-dependent protein"
                     /protein_id="HBH0030951.1"
                     /translation="MDILDDIAECILNMGVDNIENLVKIAIDKNIDVEDIYEYGLNKG
                     MIGALDKFENKEYYLSEVIVCTDALNKGINLLKGTGKVKKKSKGVILMSVVEGDTHEI
                     GKNIVKVMVEATGYKVIDLGVNRKSEDIIEEAIKNNVDIIGLSSMMTTTMENMKSVID
                     ELNMIEIDKRPKVIIGGGPVSMEFAEEIGADGYSSNAPKAVKLINKLIGGEV"
     gene            3534..4556
                     /locus_tag="KR257_002268"
     CDS             3534..4556
                     /locus_tag="KR257_002268"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893254.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="methyltransferase"
                     /protein_id="HBH0030952.1"
                     /translation="MFSDMTLLQYINSEDRGFFLPDMGTNGLFLINKKAYEVYDSVDL
                     QLELAKTMDKYFESDFIYSFCDGITFCETLGLDTLRPDYDFPSVLTHTITDRDKLRKL
                     DVPDPYTSGRMPLNIESLSVISKSIKKPLYESIQGPFTLAGQLAGATQLLRCIITDKK
                     FVEELLEFTTELVRRYAVAANKAGAKYISIAEPTSVTLSKDRFDEFIVKNLNKIYNEL
                     DCWKGMHICGDTRELLDNMLSCNIDAVSLDQILDYEEIAPMIPRDIVLIGNLDPIKLL
                     GRSKPDKIRRETLKLLKKMRRYDNFLCDFGCNCLNTTPVENLQAAIKAGRISYKELDR
                     IDIDEL"
     gene            4546..5166
                     /locus_tag="KR257_002269"
     CDS             4546..5166
                     /locus_tag="KR257_002269"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861318.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0030953.1"
                     /translation="MNYNSNKNKYLLKDINLDDIFIDKNIVLKFLGYGNRKAPDTISK
                     IVEREIRNINDILDIKIYISEVDINKTPKECKKAFAVLYTIGDKIDFKMNDYMENCNM
                     MAGLALDKVGIVCLDCINEKIKMYLKGKYDSLKISHEIYPGDKDFEVERQKDIYNYVK
                     NKYNSIEIEINDYHQLSPIKSVAMLILMGDEENLESRCSKCPRKCF"
     gene            complement(5290..5976)
                     /locus_tag="KR257_002270"
     CDS             complement(5290..5976)
                     /locus_tag="KR257_002270"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861319.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YjjG family noncanonical pyrimidine
                     nucleotidase"
                     /protein_id="HBH0030954.1"
                     /translation="MKTYKFIFFDADDTLFDFKKSESHAFKKLLSEFDLEFNFENYIE
                     SYRNISDKLWLDLEKNIITLNELKLLRFELFANKISLDVDSETLSKMYLNFLGECTFL
                     IPGAIDILQYLKKKYTIVIITNGISAVQKKRLENSKIKEYIDGMVVSEELKISKPNPE
                     IFKYALKKFNCHDKSSALIIGDSLTSDILGGINSGIDTCWLNSNNSINYTNHIPTYEI
                     NTLIELKKLL"
     gene            complement(5990..6535)
                     /locus_tag="KR257_002271"
     CDS             complement(5990..6535)
                     /locus_tag="KR257_002271"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454415.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="HBH0030955.1"
                     /translation="MNDLNLGEKIAEVRKKQNLSIRDLAKLADVTPSLLSQIERGLAN
                     PSVNSLKSIASSLNVPLFTFFVSEVDKKNLIVRHDNRKKVILPGSKEVIYEILIPDSS
                     GNLEFAIMDLAPNTSSCVDRITHNGDEIAYVLEGEVKLFMDDDEFTLSKGDSVKVPLG
                     TKHKWQNDSNSESKVIFAVIL"
     gene            6763..8010
                     /locus_tag="KR257_002272"
     CDS             6763..8010
                     /locus_tag="KR257_002272"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728591.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GntP family permease"
                     /protein_id="HBH0030956.1"
                     /translation="MQITTFGAIFGLLIAIILIIKKFQAVYSLMLGAFIGGLVGGANI
                     TQTVDFMANGAMNISPSILRALASGVLAGSLIKTGAVDKISEQIVKIFGEKRALFSIA
                     ISTMVLAGVGVNLDVSIITVAPIGLYIGRKLNYSKLSILLAMLGGGKAGNIISPNPNT
                     IAVADNFSVNLSSVMMANIIPAIIGVVITVILASILINKGNKVQSYEILEQREDLPSL
                     FKSLCGPIIAIFLLFLGNVSPIVIDPMIALPIGGIVTLIVTGNLNNSREYLAFGLSKM
                     QGVCILLLGTGTIAGIIQMSELQQSTIGALQFLNMPQFLLAPVSGILMSLATASSTAG
                     ATIASSTFHDAIINGGLSPISGASIVNAGSSVFEQLPHGSLFHTSAGSINMDIGERFK
                     LIPYEALIGIVMTIISTSIQLVL"
     gene            8097..10091
                     /locus_tag="KR257_002273"
     CDS             8097..10091
                     /locus_tag="KR257_002273"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889695.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transporter substrate-binding domain-containing
                     protein"
                     /protein_id="HBH0030957.1"
                     /translation="MNKKKIVIIGIIYSFLVVFSLTNMYVNMEYNLNVFEYIKKSLPF
                     TEEEKKWLEKHKNLIYSSDQSSPPLRYKGKEDGQYKGIIVDLINSLSIQIGRDFYFKP
                     NNWWKESFVNSIDDSIKFFDLIPSKERANKFIFTDPIYTLSANILKDKKSQDINSYMD
                     LKGKTVAIPEGDYSINFLKQKIQDINILLTPDIKTGVNHLMSGKVDAVVGDEPVLRYY
                     INNYGLSNKYSVLSNPIYTKKAVLAVPKQYEELVSILNKGIFKLQKNGVYKDLKKKWY
                     STYNEVDDILYERGIVPSIYLFIGIILISIYVFYSYTYLLKIEIKRKTEQVIENKKTL
                     EATFNSITDIIMLVDENNNIVESNKVLYDFMGEMSYKIADLISMIKGVIENTFSENTN
                     KTSEIEIHNKILKINTFPVEYKKNNTEYIVVLIKDITNDKIVEAKLLRENKMISIGQL
                     ASGVAHEIRNPLGIIRNNCYLLKDNVTMEEVNDCVKSIESNVDRASNIITNLLNFARI
                     SDDNLEHINIRNFIENIVKLQYKMLQLKNVEIKIDCEHNLVCYINGESLKHVFINLIS
                     NSIDAIHQDGKIIIYCYEKNYCLFIDFKDNGEGIKEDALKDIFNPFYTTKPIGEGTGL
                     GLYITYNEIKKNNGDISVESKLGVGTCFHIKIPLNKEVTI"
     gene            10091..11413
                     /locus_tag="KR257_002274"
     CDS             10091..11413
                     /locus_tag="KR257_002274"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423653.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sigma-54-dependent Fis family transcriptional
                     regulator"
                     /protein_id="HBH0030958.1"
                     /translation="MKILLVDDELEYGVVMKKILQKKGYLVDIALSGEEAINIIKKDK
                     NYDLVLSDVMMKNMDGVQLLDRIKSINRDIEVILVTGYGSIENAVDAMKRGALSYFIK
                     SNPIENLLEEVEKVKASKISVSVQKNNLEFTLESKNRDFNNIIKIAKKAACKDVNILI
                     LGESGVGKDILARYIHSISPRKNEIFVPVNCCSFSENLLESELFGHEKGSFTGAVDSR
                     KGRFELSNKGTLFLDEIGDIPLNVQVKLLRTLEDKSIERIGSNKSIKVDFRLICAMNK
                     EPKVEISNGNIREDFFYRISTITITIPPLRKRREDLTTLIEFFLNKYQIEHDKKIHSI
                     DKEVKDFLLNYNYPGNIRELKNIINRLVVLSEEGNLSKDNLNLISNNVYIDDKISIRP
                     LREIRKEFECEYIEKVLSLCGNNISNTAKKLEISRRQLTNKISEYNIK"
     gene            11692..12978
                     /locus_tag="KR257_002275"
     CDS             11692..12978
                     /locus_tag="KR257_002275"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006807454.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycine/sarcosine/betaine reductase component B
                     subunit"
                     /protein_id="HBH0030959.1"
                     /translation="MKLELGNIFIKNVEFGEKTEVKDGVLYISSEEIEKIVLEDERIV
                     SVNVELARPGESIRIAPVKDVIEPRVKIGDESKIFPGIINKVKTVGSGRTHVLLGACV
                     VTCGNIVGFQEGVIDMSGPTAKYTPFSKTNNICIVIKAKDGIDTHDYEEAARIAGLKI
                     GAYVGEAGREVEPDEVIVYETKPLLKQVKEYPDLPTVAYVHMLQSQGLLHDTYYYGVD
                     AKQIVPTFMYPTEIMDGAIISGNCVAPCDKVTTFHHLNNPVIHDLYKRHGKDLNFIGV
                     ILTNENVFLVDKERSSDMVAKLIEFLGVDGVLVTEEGYGNPDTDLMMNCRKCSEVGAN
                     VVLITDEFPGKDGKSQSIADATKEADAVVSCGQGNLVVHFPAMEKIIGTLDYVEMMIG
                     GYKGCLNEDGSMDAELQIIIASTIANGYNHLTARYY"
     gene            13064..14371
                     /gene="grdB"
                     /locus_tag="KR257_002276"
     CDS             13064..14371
                     /gene="grdB"
                     /locus_tag="KR257_002276"
                     /EC_number="1.21.4.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012158817.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_except=(pos:14111..14113,aa:Sec)
                     /transl_table=11
                     /product="glycine reductase complex selenoprotein B"
                     /protein_id="HBH0030960.1"
                     /translation="MSKIRVVHYINNFFAGIGGEEKADIPPEKRAGVVGPGIAFQSQF
                     NDDAEIISTVICGDTYFGENIESATQELLKMIKEESPDLFIAGPAFNAGRYGVACGTI
                     CKAVEEELNIPVITGMYKENPGVDMFKLDLHIVSTGNSAASLRKVVPIMTKLGLKLVR
                     GEEIGPPEEEGYIMRGIRKNFFHELRGSERAIDMLVKKMKGESFETEYPMPEFDRVTP
                     MKPVKDLSKIKLALVTSGGIVPIDNPDKIESSSATKYGIYDLTDMDSMSNKEFTTIHG
                     GYDRAYVLENPNLVVPLDVVRELEKEGVIGELVDYFITTTGTGTSVGNSKRFGEEFSK
                     KLLEDDVDAVILTSTUGTCTRCGATMVKEIERAGIAVVHICTVVPISLTIGANRIVPA
                     VGIPYPLGNPMLGEEESKKIRKNIVLKALNALTEDIEEQTVFE"
     gene            14649..15380
                     /locus_tag="KR257_002277"
     CDS             14649..15380
                     /locus_tag="KR257_002277"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454401.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HBH0030961.1"
                     /translation="MIRKKVYILISIAICDDESYMLNHLKENIELYMKQKNLLYNIEL
                     FNKVEDLLCNHEKFNIVFLDIQMEEINGMQAARKLRSYGNECFIIFVTVLNEFVFDAF
                     EVDAINYLIKPLSNEKLYKTLDKIVTKLDDNESNYITIQKGYSYWKLKLADILYCEVI
                     KRKIYVHLKKETVDYYETIENLERSLPTNFFRCHRSYIINLQYVYGYENGNAVMESGD
                     RIPVSRLRQQIFSKVMLEFMKNRRI"
     gene            15382..16740
                     /locus_tag="KR257_002278"
     CDS             15382..16740
                     /locus_tag="KR257_002278"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896878.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GHKL domain-containing protein"
                     /protein_id="HBH0030962.1"
                     /translation="MINLFSSDLFLKYSFLFSFIVYRILMVIVQYYFLISFTNVNSKF
                     WCFILYSIISIFLIIINTYFNLYNLFSSQILFFLMTFLFVKYIIKQSTVLSIVSTLLV
                     YLIEQLVYGFTAPLNYLIFTSDINTDIYKFDINMGLSSLITIIIAGFIYWYSSKKFNI
                     KVMNFDKYIAILMIPLLLIILFMQSFEYSSNINIDTSLGIVKLLLNTSITEEIQAFLF
                     SIIGTICVFFSLFTFKKLIQALEDDKERAIMNQQIHAQKNYIEEAKSRLSQTISFRHD
                     FNNHLAIVNGLLKKDQILKAQDYLNKLEKVTSDLSFSCNTQNIVIDALFNNKLSIAKQ
                     LGIEVDCEVIIPQSTNMNDFDLCIVFANAIDNAIKACRVVDKQNRYLKLSTKLEGGFF
                     MIEIKNSYNPINNYTSGSGIGLLNIKEIAKKYQGAISIDKTSDYFQINVLLVISLHCA
                     SI"
     gene            16779..17264
                     /locus_tag="KR257_002279"
     CDS             16779..17264
                     /locus_tag="KR257_002279"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454396.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0030963.1"
                     /translation="MYLNRESLIYRNEEVTKMKVGNINGQAPITNGLDSCQSEVQGLE
                     QKKKSLQDEIEKVRSDKSIDGETAKLKIEALKKEMEEIENKIQELKGNKAKKTNKEEN
                     NVSEVNNNLLERKKEPSNNENVKQLYDVFERSNVDEQWDNTYRVLQDDKNLKVKFNRP
                     I"
     gene            complement(17527..17763)
                     /locus_tag="KR257_002280"
     CDS             complement(17527..17763)
                     /locus_tag="KR257_002280"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430229.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0030964.1"
                     /translation="MLLTHIYFNGQFKQTIELYKQAFNATVKTLIEDSCYLLIVHNEI
                     VIHNKFLILNDFGNKNGVSISEGYQPTDKIQTAS"
     gene            complement(17918..18142)
                     /locus_tag="KR257_002281"
     CDS             complement(17918..18142)
                     /locus_tag="KR257_002281"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423664.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ferrous iron transport protein A"
                     /protein_id="HBH0030965.1"
                     /translation="MTVYNLKLGQKGIIDNIAGNEKLMKRLLALGLIDGTEVEVKKIA
                     PLNDPIVIRFRGFDLAIRKSDAKNINLKNN"
     gene            complement(18239..19492)
                     /locus_tag="KR257_002282"
     CDS             complement(18239..19492)
                     /locus_tag="KR257_002282"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902743.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sodium:glutamate symporter"
                     /protein_id="HBH0030966.1"
                     /translation="MITLSFDIVQTLTLSIFFFLIGNLLKNKVNFLNNFCIPAPVIGG
                     LLFCFLNLFFKYFNIADISISGNLMPNFITFFFTTIGLEISINLIKKGGSVLFRYWIL
                     CGVLAFCQNILAITISKIIKLEPLLGLMCGNVSMEGGHGYSAAFGLTIENLGIEGAVG
                     VGLSAATIGLIMGGILGCPVAKFLINKYKLKPSSNIDLSIPRYNRNLKRFGSKFFRNK
                     NRIKNNNFSETITPSVFLEQVLLIFICINTGEIISRCFYITFNILLPSVVTCMFSAVI
                     FRNLNDKINILELNFKLIDFLKELSLGIFLTLSLMNIDLFELSTLLPPILLIVTFQVI
                     FIILFSIFICFRVLGKDFDSAIIISGLIGHGIGATPNALANMSSLTQKYGDSPKAFLV
                     VPLVSGFLLDAISIPCILFFINILT"
     gene            19752..20741
                     /locus_tag="KR257_002283"
     CDS             19752..20741
                     /locus_tag="KR257_002283"
                     /EC_number="3.5.4.4"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454392.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="adenosine deaminase"
                     /protein_id="HBH0030967.1"
                     /translation="MFENLPKIDLHCHLDGSVRVETMLDIAIKEKIDLPSNNMDEIKK
                     LAKVSFNCTSLDEYLEKFDLPLKVMQSKENLKRITFELLEDASRENVKYIEIRFAPLL
                     HTQKGMSVKNIIEGIIEGIREAESIYDIKGNLILGCMRTMTSKEALLVIEEGKSFVNK
                     GVVAVDLCGPEKEGFCKEYKDVFKLAREYGYKVTIHAGEAASGENVLDAINILKADRI
                     GHGVKIKDHKKAYNLVKDKKILLELCPTSNVQTKTVDSYEAHPFYTFYKDNLHVSINT
                     DNRTVSDINLSSELNVIFDTFKLGLEDYKIIYRNAVEASFADKETKEYLNSLI"
     gene            20813..21553
                     /locus_tag="KR257_002284"
     CDS             20813..21553
                     /locus_tag="KR257_002284"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454391.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="EcsC family protein"
                     /protein_id="HBH0030968.1"
                     /translation="MKDYEDVVYIKLVKKELEEWKKNILKKPSIFDKASKGIQNKFNG
                     VLPDKYHEIITSSIKVMTKTVLFGYKYATKPPLRNMSLEEREKLVLEKAKTYKTTAMI
                     EGAGTGAGGILLGLSDFPLLLGIKVKFLYDVASIYGYDVKDYRERIYILNILQLAFSS
                     QQHINKTFKLMNNWDEYVNSLPEDINDFDWRTFQQEYRDYLDLAKFLQLMPGIGAFVG
                     FYVNGKLIDKLCETAVSAYRLRIRELKL"
     gene            21769..22920
                     /locus_tag="KR257_002285"
     CDS             21769..22920
                     /locus_tag="KR257_002285"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454390.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="2-hydroxyacyl-CoA dehydratase"
                     /protein_id="HBH0030969.1"
                     /translation="MTNLPKQFDSFNEARQKGFINAKELKESGKKMVGVFCTFTPVEI
                     PMAAGATVVGVCGVSEEPIPDAERVLPRNLCPLIKSSYGHAITDTCPYFYFSDLLIGE
                     TTCDGKKKMYEELAKVKPTYVMHLPNTSKGEFAYKLWKDEMIRLKEEVEKSLGVTITE
                     EDIRTAIKDKNEERELLKEFYALGKLQPSALTGLELHNVLYQAGFKFDRAELKHSLRK
                     VIDDMKERYEKGECPVQKDKPRILITGSPIGGISEKIVKTLEDAGASVVAYELCGAIR
                     SNDLLVDEEIEDVYDALTQKYINIGCSCMMNNDNRIELLDRIIDEYNVDAVIDVVLQA
                     CHTFNIESYRIREFVTKEKNKPFMSLETDYSKSDTEQLRTRFEAFVEML"
     gene            22945..23700
                     /locus_tag="KR257_002286"
     CDS             22945..23700
                     /locus_tag="KR257_002286"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430240.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="2-hydroxyglutaryl-CoA dehydratase"
                     /protein_id="HBH0030970.1"
                     /translation="MFSIGVDSGSVATKGVLFDGEKIIKKIIIPTGWSPKSTSKQVYE
                     LLSSEIDKKDIKKVVGTGYGRGVMDFADKKVTEITCHTRGIYFLNKNIRTILDVGGQD
                     SKVINLDRDGNVFNFIMNDKCAAGTGRFLEITSNLLGSDIESIDTLAKGYEPVNISSM
                     CTVFAESEIVSLLAQNISTGEVAAGILKSIANKSTSMLARGEVIDEVAFTGGLAKSKE
                     LVKMIEEILGKKIFIAEDTQIIGALGAAVIGFR"
     gene            23892..26279
                     /locus_tag="KR257_002287"
     CDS             23892..26279
                     /locus_tag="KR257_002287"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861325.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell wall-binding cysteine protease Cwp13"
                     /protein_id="HBH0030971.1"
                     /translation="MKKFTSKKVTRFVALFLISILVMSTIPVSADNSNTLNQIKKAEY
                     SETYKQYLNDAKNGCTEKYNGIIPNPYQLEGTQIQSKGRTAPTSYDPRKLGLMTSIKN
                     QEDLGICWDFAAMATLESFLKLNNYGDYDLSEEHLRWWASDGEYGWSVNDMNGALNYE
                     AMGYLTSWSGPKLEKDIPYNGRVSKAQGAKKPTNMNTAPTVFNVTDAVCVSNDINSTK
                     NAILQYGAVTSGYYEDIKYQSDDQNSYYCPTKSFNTNHAISIVGWDDNYSKDNFNANI
                     RPSKNGAWLIKNSWGDYNSEGGYFWISYEDKTLMSDIDNFSIKGGKKPNDDEKMYQHD
                     YASIVPLISKKITAANVFDFNRGDETLKSVMFLTESIGAKYEVYYAPVVNGIPQENNM
                     KKLKEGTAQYSGYITVPIDSFDIPEGKGAIVVSIEGKNGESTIGSESNVPGYDTFKAK
                     ANLGESYIIDNTGKFFDINRDSNFYPCNFTIKAVTEKSSGESIPNESLIGSDRYETAI
                     KVSQNGFNSSENVVLVNGSSIVDALAATPFTSAINSPILLTQKEALNSKTKAEIQRLG
                     AKKVYLIGGENSISKEIEQQLKSLNISIERISGSDRYKTSLLLAQKLNGIKNVSQIAV
                     VNGVKGLADAISVGAAAAENNIPIILANEKSELQGADEFLNSLNIEKSYIIGGTASLS
                     NNLESKLKNPTRLSGSSRDETNSKIIDNFYKKDTLKNAFVVKNGIKNQNDLIDGLAVG
                     PLGAKTGSPVILVGDKLADSQKEVLKNKTLEKVTQVGGGANKNAFKELVKLKSAK"
     gene            complement(26510..26743)
                     /locus_tag="KR257_002288"
     CDS             complement(26510..26743)
                     /locus_tag="KR257_002288"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430242.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATPase"
                     /protein_id="HBH0030972.1"
                     /translation="MATTTKNRFYDYVQENLNKYVEVHSYFSSCPLYGEIIEADSLSI
                     TLCSRYIDESNPTLNETYTLYLPLSSIISIRTL"
     gene            27032..27622
                     /locus_tag="KR257_002289"
     CDS             27032..27622
                     /locus_tag="KR257_002289"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454386.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="HBH0030973.1"
                     /translation="MPKSYSDKEREYIIKRLKEEARLCMEQYGIRKTTVDELVKRVKI
                     PKGTFYLFFQSKELLFFEVLRDIHDSIQKEILYEINRVDESITCEQLTDIFMKFYRMV
                     DSTSILNLMINGEFEILVRKLPDSIIEEYFRHDDFEIGEIISCIPNAKNKDIESFSGA
                     FRAVFLTMLYKREVGSNCFEDALRLMINGLVIQLME"
     gene            27736..28581
                     /locus_tag="KR257_002290"
     CDS             27736..28581
                     /locus_tag="KR257_002290"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892238.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBH0030974.1"
                     /translation="MIKVDDLSFSYTDRDFLQNINFEVGKGEILGFLGPSGAGKSTLQ
                     KILIGMITNYGGSVIVNGVESKRHSNKFYENIGVDFEFPSLYEKLTAIENLKYFGSLY
                     SKKLLSIDELLKSVGLENESNKRVSEYSKGMKSRLNFIKALLHNPDILFLDEPTSGLD
                     PSNSKVMKDIILSEKSKGKTIILTTHNMLDATELCDRVAFIVNGKISALDTPHNLIMS
                     KGAIKVRYTYFDNGEKTSECFLNNTANDKNLNMLIEKNKLLSIHSSEPTLNDIFIEIT
                     GRNLQ"
     gene            28578..29261
                     /locus_tag="KR257_002291"
     CDS             28578..29261
                     /locus_tag="KR257_002291"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902753.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBH0030975.1"
                     /translation="MRLKNLILGDIKFQFKYGFYFLYLFLSIIYICIINVFPTFMREK
                     IAIIMIYSDPAAMGLFFMGAIVLLEKSQRVLNSLAVSPVKVSEYILSKVISLGVISSI
                     VAMFIAITLNLDNIIISTIGTFFSSIIFSLLGLIIASKASSLNQFIVLSIPIEIICFI
                     PPILNVLLDTKSYANLYPFNICISLISGDKNFIMINILILISIIIIIYFITYYFICSS
                     WKKVGGVKL"
     gene            29258..29974
                     /locus_tag="KR257_002292"
     CDS             29258..29974
                     /locus_tag="KR257_002292"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902755.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBH0030976.1"
                     /translation="MIKIINAFKQEFEQIKRDAMLFIVCVSPILCGVFIKFGIPLIQN
                     ISLNKFYYQLNLEPYFLMFDLLLAFITPFMFFFASTMVILGEIDDSISRYLIVTPLGK
                     TGYLISRFGIPGILAFIITMILLIFFSLTKISLLLNLSISLLVLLQGVIISILVISLS
                     SNKLEGMVITKFSGVFMMGILAPFFILNKAQYILFFLPTFWISKAFKEDNYVYMFISI
                     VISLIWILLLFKKFSKKIVK"
     gene            30071..30334
                     /locus_tag="KR257_002293"
     CDS             30071..30334
                     /locus_tag="KR257_002293"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423694.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HBH0030977.1"
                     /translation="MKNKIKILREKLGLTQEQLGRLVGTSRQAINAIETGKNEPSIWL
                     AYDISRIFNEPIESVFLFEESERKSRAQISRGEYYGYKKDKNI"
     gene            30306..30761
                     /gene="def"
                     /locus_tag="KR257_002294"
     CDS             30306..30761
                     /gene="def"
                     /locus_tag="KR257_002294"
                     /EC_number="3.5.1.88"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728601.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptide deformylase"
                     /protein_id="HBH0030978.1"
                     /translation="MAIRKIRTFDDEILRKKSKYVENVDNKIREILNDMAETMYNTPN
                     GGGLAACQVGVLKRLVVIDLGEGLIKLVNPEIIEQEGEQIVVEGCLSFPEVWGKLKRP
                     KKVTVQALNEYGEKIEIKGSGFMAKCLCHEIDHLNGIVFTDKIIEHVKL"
     gene            30813..31274
                     /locus_tag="KR257_002295"
     CDS             30813..31274
                     /locus_tag="KR257_002295"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454381.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pyrimidine dimer DNA glycosylase/endonuclease V"
                     /protein_id="HBH0030979.1"
                     /translation="MRLWHKDLIDVLPKNQLVSQWRELLAIKGSIDKKGTPNHLLVNK
                     VLNYSIDEFKFYTKIVHDEMLKRNYKPNELKYTSILKWKNRNFANDISNEHSLNLENL
                     YDDWHNKMYLKQCLYNLEEKATCGGIPINEWNILLCKYSKDYELWSGNIMF"
BASE COUNT        12476 a         3277 c         5170 g        10415 t
ORIGIN      
        1 atgaatgatg ttagaaactg taatatattg gatataatat aataaacaga taaactctgc
       61 attaagagga tatatagttt atcttaatta taggggaagt gaggatatat tatggaaaga
      121 ttaatggaac tcatagaaag aaaattttta aaggatgtag aacttttaga attagaagac
      181 atagaaaatg taatagaatg caaaatgaca cagccatata atgctcatta taatgaatat
      241 ttagtaaaag taaaaaatgg agatgaagta gaagaatatt ttgtgtattt aaaacataga
      301 taaacataaa agaggtttat atttatttgt atgattataa aataaataca agcctctttt
      361 tttgataaat ataaaattat aaaattttta tttatttaat tttttcaaca acattagtca
      421 atattgaatc taaatcatca ctaatttctg taactccatt atgagtaata tctataattt
      481 ctttagtcat aggaagttct cctaaaagct ctaagtctaa atcatctaaa aacttttcag
      541 tagattctcc ttcaaataac ttgatttttt tagaacaatc aggacattgg atataactca
      601 tattttcaat aactccaagg acatttatgt tcattttttt agccatatta acagcttttg
      661 atacaatcat agataccaaa tcttgaggta ctgaaaccat aactattcca cttataggaa
      721 tagattgcat aactgttaag gcaacatctc cagtaccagg aggcatatct attaataaat
      781 agtctaattc ttcccaaagt acatcagtat aaaattgctt tacaacccct ccaagtaaag
      841 gtcctctcca aacaacaggt tcattttcat catctatcat aaggtttata gacattactt
      901 ttatgttatt tgagttttct acagggtaaa tataagagcc atcagaataa gcttttacat
      961 tttttacacc cataagtcta ggaatacttg gtccagttat atctgagtct aatataccaa
     1021 ccttatatcc cattttgttt agcttattag caagtaaagc agttacagtt gattttccaa
     1081 ctccaccctt cccactcata acaccaatta tttttccaaa tttattgtta gggttatttt
     1141 caatagaaca atttgattga ctattacaat ttccctttga tggacatgaa ttacaatctg
     1201 ccatatctat tacctccaaa ctttaatatt tattagatta tttgtaacct acatatacta
     1261 ttttagtaca attgaaccat aaagtcatta tttaaaagca acttagaaga ttttctattg
     1321 atttattcat agactatagc aaaaagaata caataaaaaa attataacat tcttgaaaaa
     1381 gtgattattt caatttagtt atagaactta gtcatataaa tatatagaaa atattttaat
     1441 atattataca taacgggtta ttttataagt ttaactataa attaggttta tattttataa
     1501 aaatttgcta aaaaaaacaa ttaaaaattg taaagaaaaa agatataatt agaactgtag
     1561 taataaatgt tttattatag ataatagagt tttaagtatc ttaaataata tttggaggaa
     1621 tatgaatgga attaagacca agaagtgcaa aattagaaga atttgataaa gtaatagaat
     1681 taataaacta tgtatttaga atatcaagaa atcataaacc aactatgatg gaagaatttc
     1741 ctcttttact aagtaaaaat aatatagaaa atatgattat aatatcagaa gatgataaag
     1801 tggtttctga tgtaaactat ctaattcagg atgtatctat tcaaggaaac agattgaagg
     1861 ttgcagctat aggtggagta tgtactcatc cagattatga aaagagaggc tattcatcta
     1921 agatattgga taaagtagaa gaaaaaatgt tttatgatgg tgtagatatt gtaattatat
     1981 caggaacaag aagtctatac agtagaagaa attgtagttt ggtaaagagt ttttataaat
     2041 atacaataaa acctgaagat gtaaaaatag catatgaaat agttgaattt gatgaaacta
     2101 attttgaaaa agataatgat ttagataaaa tgattgaact atataatcaa aatagtacta
     2161 gatttataag aacgagagat gagtttcaaa aactattgca tgcagcaact attgcctggg
     2221 gaccaattgg ttacaagaag gtatttataa aggaaaataa taatataata ggatatttga
     2281 taataagaac aataaaaaaa gaagattcta ctgtaggaga agttgctgaa atagggttaa
     2341 actctgtaaa tgttgaaaat atattgaaat atgttgcaaa taaatttgga ttagaatctt
     2401 taaattataa agtacatgtg aaaaatctta aagaccagtt gaaatgtaat gggacaaaat
     2461 ctttggatta tcaacaagga actatgaaaa taataaattt tactaagttg tgtgatagtt
     2521 taagaagtta ttttagtcaa tatgtagatt ttgaattact aaaatacatg gaatttaaac
     2581 aagttgaaaa taaatatatt attaaataca aagaagaaga acttgtaata gaaaatttgg
     2641 ataagcttaa taaactgttt tttgaaaaaa atgaggaaca gtacaatgaa tttaaacatc
     2701 taaaaaatat atatgaattt gctacaaagg catttcctgt agattttcca tggactgcaa
     2761 atttaaatta tcaatagttt tagatgatat taaataaaat tgattgatac ctagagttag
     2821 tccttgttaa ataagagaaa ttattggata ttgaaaaagc aattttgtaa gtaattagaa
     2881 aggatgagta ttatatggac atacttgatg atatagcaga atgtatatta aatatgggtg
     2941 tagataatat agagaattta gtaaaaattg ctatagataa aaatattgat gtggaagata
     3001 tttatgaata tggtttaaac aaaggtatga taggagcttt agataagttt gagaataagg
     3061 aatactatct ttcagaagtt atagtatgca cagatgcatt aaataaaggt attaatcttt
     3121 tgaagggaac tggaaaagta aagaaaaaat caaagggagt aattctgatg tctgtagtag
     3181 aaggagatac tcatgagata ggaaaaaata ttgtaaaagt aatggtagaa gccactggat
     3241 ataaggttat tgacttaggt gtaaatagaa aaagtgaaga tataatagaa gaagctataa
     3301 aaaacaatgt agatataata ggcttatctt caatgatgac aactacaatg gaaaatatga
     3361 aatcggttat agacgaactt aatatgattg agatagataa aagaccaaaa gtaataattg
     3421 gtggaggacc tgtaagtatg gagtttgcag aagaaatagg agcagatgga tacagttcaa
     3481 atgctccaaa agcagttaaa ttaataaata aacttatagg aggtgaagtt taaatgtttt
     3541 cagatatgac tttacttcag tatataaata gtgaagatag aggttttttt ctgcctgata
     3601 tgggtacaaa tggattgttc ttaataaata aaaaggcata tgaagtatat gatagtgtag
     3661 atttgcaatt agaattagca aagactatgg acaagtattt tgaatcagat tttatatact
     3721 cattctgtga tgggattaca ttttgtgaaa ctctgggttt agatacatta agaccagatt
     3781 atgattttcc aagtgtattg acacatacta taactgacag agataaatta agaaaattag
     3841 atgttccaga cccttatacg agtggacgta tgccactcaa tatagagagc ttatcagtta
     3901 tatcaaaaag tattaaaaaa ccactatatg aatcgataca aggtccattt acacttgcag
     3961 gtcaattagc tggagctact caacttttaa gatgtataat aactgataaa aaatttgtag
     4021 aagaattatt ggaatttaca actgaattgg taagaagata tgctgtagct gcaaataaag
     4081 caggagcaaa atatatttca atagcagagc caacatcagt aaccctaagt aaagatagat
     4141 ttgatgaatt tatagtaaaa aatttaaata aaatctacaa tgaacttgat tgttggaaag
     4201 gtatgcatat atgtggagac accagagaat tattagataa tatgctaagt tgtaatatag
     4261 atgcagtaag tttagaccaa attttagact atgaagaaat tgctccaatg attcctagag
     4321 atatagtttt gattggtaat ttagacccaa taaaacttct tggacgttct aagccagata
     4381 agattagaag agagacacta aaattgttaa agaagatgag aagatatgat aactttttat
     4441 gtgattttgg ctgtaactgc ttaaatacca ctccagtaga aaatttacaa gcagctataa
     4501 aggcaggaag aattagttat aaagaattag ataggattga tattgatgaa ttataatagt
     4561 aataaaaata aatatctttt aaaggatata aatttagatg atatttttat agataagaat
     4621 attgtgctaa agtttttggg gtatggaaat agaaaagctc cagatacaat tagtaaaatc
     4681 gttgaaagag aaataagaaa tataaatgat attttagata tcaagatata tataagtgaa
     4741 gttgatatta ataaaacacc taaagaatgt aaaaaagcat ttgctgtact atatacaata
     4801 ggggataaaa ttgattttaa gatgaatgac tatatggaaa attgcaatat gatggcaggg
     4861 ctggcattgg ataaggtagg tatagtatgt ttagattgta ttaatgagaa aataaaaatg
     4921 tatttaaaag gaaagtatga tagtctcaaa atatcgcatg aaatatatcc aggagataaa
     4981 gattttgaag tagagagaca aaaggatatt tataactatg taaaaaataa atataatagt
     5041 atagaaatag aaattaatga ttatcatcaa ctatccccca taaaaagtgt tgcaatgctt
     5101 attttaatgg gggatgaaga aaatttagaa tcaagatgta gtaagtgtcc tagaaaatgc
     5161 ttttagttaa ttttcaagac taagatttgt tttgtgtata aattgcaata atttttttgg
     5221 tcattttatg tataaactaa aaaaattatt gcaaagtaat attctattta atttgaacag
     5281 acttacaaac tatagtagtt tctttaattc aataagtgta tttatttcat aagttggtat
     5341 atgattagta taatttatac tgttattgga atttaaccaa caagtatcta ttcctgaatt
     5401 tattccacct aagatatcag aggttaagct atccccaatt attaaggcag aagatttatc
     5461 atgacaatta aactttttga gagcgtattt aaatatttca ggatttggtt ttgatatttt
     5521 caactcttca gatacaacca ttccatcaat atattctttt atttttgaat tttcaagtct
     5581 tttcttttga actgcagaaa ttccatttgt tattataaca atagtatact tttttttaag
     5641 atattgtaat atatcgattg cacctggaat taaaaatgta cattcaccta aaaaatttaa
     5701 gtacattttg ctaagagttt cagaatcaac atccaaagat attttatttg caaaaagttc
     5761 aaatctaagt aatttaagtt cattcaaagt tataatattt ttttcaaggt cgagccaaag
     5821 cttatcactt atatttctat atgactctat ataattctca aaattaaatt ctaaatcaaa
     5881 ctcagataga agttttttaa aagcatgtga ttcacttttc ttaaaatcaa ataaagtatc
     5941 atctgcatca aaaaatataa atttatatgt cttcatggtt tttactcctt tacaagatga
     6001 ctgcaaaaat tactttactt tcactatttg agtcattttg ccatttatgt tttgttccta
     6061 aaggaacttt tacactatct cctttggaca aagtaaattc atcatcatcc ataaaaagtt
     6121 taacttctcc ctccaaaaca tatgcaattt catctccatt atgagtaatc ctatcaacac
     6181 aagaagaagt gtttggagct aaatccataa ttgcaaattc taaattacca ctagagtctg
     6241 gaattaaaat ctcatatata acttctttgc ttccaggtaa aataactttt tttctattat
     6301 catgtcttac tatcaagttt tttttatcta cctcagatac aaaaaatgta aataaaggaa
     6361 cgtttagaga agaggctata gattttaatg aatttacaga tggattagca agacctcgtt
     6421 ctatttggct caataatgat ggtgtaacat cagctagttt tgctaaatct cgaatactta
     6481 agttttgttt ttttcgaact tcagctattt tttcccctaa atttaaatca ttcatataaa
     6541 tatcctctct ttttaattta aaaaatatta acttaaaata atcaagtaaa atgattatgt
     6601 agtatgaaat tattataaca tatagaatta ggttttgaaa aaactatgtt caatataatt
     6661 aaataaatta aaatataatt gacaaagtgg atacagaata cttaaaatat atttaaataa
     6721 aattaagcaa aagatagtta atttatgata ggaggggata ttatgcaaat aacgactttt
     6781 ggagctatat ttggtttatt aatagcaatt attttaatta taaaaaaatt tcaagctgta
     6841 tatagtttaa tgctaggagc atttattgga ggattagttg gaggagcaaa tataacacaa
     6901 actgtagatt ttatggcaaa tggagctatg aatatatcac catcaattct tagagctttg
     6961 gcatcaggtg tattagctgg aagtttaata aaaacagggg cagtagataa aatatcagaa
     7021 cagattgtaa aaatatttgg tgaaaagagg gctttatttt cgattgccat ttcaactatg
     7081 gtacttgctg gagtaggcgt aaatttggat gtatctataa taactgtagc acctatagga
     7141 ttatatatag gtagaaaatt aaattattct aaattgtcaa tactattagc tatgttggga
     7201 gggggtaaag caggtaatat aatatcacca aatccaaata ctatagcagt agcagataat
     7261 ttttctgtca atctctctag tgttatgatg gcaaatataa ttccagcaat tattggagtt
     7321 gttattacag ttattttagc aagtatatta ataaataaag gaaataaagt acaatcatat
     7381 gaaattttag agcaaagaga agatttacca agtttattta aatcattatg tggtccaatt
     7441 atagctatat ttctattgtt tttaggaaat gtatctccta tagttataga cccaatgata
     7501 gcccttccaa taggaggaat cgtaactcta attgtcacag gaaacttgaa caattcaaga
     7561 gaatatttag cttttggatt atctaagatg caaggggtat gcatattatt acttggaaca
     7621 gggactatcg caggaattat acagatgtct gaattacaac agagtacaat aggtgcttta
     7681 caatttttaa atatgccaca atttttattg gcaccagttt cgggtatact tatgtcatta
     7741 gcaacagcat catcaacagc tggtgctact atagcatcat ctacttttca tgatgctata
     7801 ataaatggtg ggctatcacc gatttcaggt gcctcaatag taaatgctgg gtctagtgta
     7861 ttcgagcaat taccacatgg ctcactattt catactagtg caggtagtat aaacatggat
     7921 ataggtgaaa gatttaagtt aattccatat gaagcattga taggaatagt aatgactata
     7981 atttcaacat ctattcaatt agttttataa taaatataaa tatttaatga aaaaagtagg
     8041 attttgttat taaatattga atttattata gtaaaaaaga agattggagt tttaaagtga
     8101 ataaaaaaaa gattgttatt atagggatta tttattcatt tttagtagta ttttcactta
     8161 caaatatgta tgtaaatatg gagtataatc taaatgtatt tgaatatatt aagaagtcac
     8221 ttccatttac agaagaagaa aaaaagtggt tagaaaaaca caagaatttg atttacagct
     8281 ctgaccaaag ttcacctcct ttgagatata aaggtaagga agatggacag tataagggaa
     8341 ttattgttga tttaataaat tctctgtcaa ttcaaattgg tagagatttt tattttaaac
     8401 caaataattg gtggaaagaa tctttcgtaa attcaataga tgatagtata aagttttttg
     8461 acttgattcc atcaaaagaa agggcaaata aatttatatt tactgaccca atatacactt
     8521 tgagtgcaaa tatattgaaa gataaaaagt cccaagatat aaatagttac atggatttaa
     8581 aggggaaaac agtagcaatt ccagaaggtg attattctat aaatttttta aagcaaaaaa
     8641 ttcaagatat aaacattttg ttgactccag atataaagac tggagtcaac catttaatgt
     8701 ctggaaaagt agacgcagtt gttggtgatg aaccagtatt gcgatactat ataaataatt
     8761 atggactttc aaataaatac agtgttttaa gtaatcctat atatactaaa aaagcagttc
     8821 ttgctgtacc taaacaatat gaagagctgg ttagtatttt aaataaaggc atttttaaac
     8881 ttcagaaaaa tggagtgtat aaagatttaa agaaaaaatg gtattctacg tataatgaag
     8941 ttgatgatat attgtatgag cgaggaattg tgcctagtat ttatcttttt ataggtataa
     9001 ttttaatatc aatttatgtt ttttatagct atacatattt gttaaagata gaaatcaaaa
     9061 ggaaaacaga acaggtaata gaaaataaaa aaactttaga ggcaactttt aatagtatta
     9121 cagatataat aatgcttgta gatgaaaata acaatatagt agaatcgaac aaagtactat
     9181 atgactttat gggtgaaatg agttataaga tagcagattt gattagcatg ataaaaggtg
     9241 ttattgaaaa taccttctct gaaaatacta ataaaactag tgaaatagaa atacacaata
     9301 aaattttaaa gataaacact tttcctgtag agtataaaaa aaataatact gagtatatag
     9361 tagttcttat taaagatata actaatgata aaatagtaga ggcgaaatta cttagagaaa
     9421 acaaaatgat atctatagga caattagctt ctggggtagc acatgagata agaaatcctt
     9481 tgggtataat aagaaataat tgctatctct taaaagataa cgttacaatg gaagaagtaa
     9541 atgattgtgt taaatcaata gaaagtaatg tagatagggc aagtaatata ataaccaact
     9601 tgttaaattt cgcaagaata tcagatgata atttagaaca tataaatata agaaatttta
     9661 ttgaaaatat agtgaaactt caatataaaa tgttacagtt aaagaatgtt gaaataaaaa
     9721 ttgactgtga acataattta gtatgctata taaatggaga atcgttaaaa catgtattta
     9781 taaatttaat ttctaattca atagatgcaa tacatcaaga tggaaaaatt attatatact
     9841 gttatgaaaa aaattattgt ttatttatag attttaaaga taatggtgaa ggaataaaag
     9901 aagatgccct aaaggacata tttaatccct tctatacaac aaaaccaatt ggtgagggaa
     9961 ctggtttagg tttatacatt acttataatg agattaaaaa gaataatgga gatataagtg
    10021 ttgaaagtaa attgggggtt ggaacttgtt ttcatataaa aattccatta aataaagagg
    10081 tgactatata atgaaaatac tattagttga tgatgagcta gaatatggag tggtaatgaa
    10141 aaaaattcta caaaagaagg gctatcttgt agatatagca ctaagtggtg aagaagctat
    10201 aaatataatt aaaaaagata aaaattatga tttggttttg tctgatgtta tgatgaaaaa
    10261 tatggatgga gtacagctat tagatagaat taaatctatt aatagagata tagaggttat
    10321 attagttaca ggatatggaa gtattgaaaa tgcagttgat gctatgaaaa gaggagcttt
    10381 atcttatttt ataaaaagta atcccattga aaatttatta gaagaagttg aaaaggtaaa
    10441 ggcaagtaaa atatctgttt ctgtacaaaa aaataatctg gaatttactt tggaatctaa
    10501 aaatagagat tttaataata tcataaaaat agcaaaaaaa gctgcttgta aagatgttaa
    10561 tatattaatc ttgggggaat ctggtgtagg aaaagatata ttagctagat atatacatag
    10621 cataagtcca agaaagaatg agatatttgt acctgtaaat tgttgttctt tttcagaaaa
    10681 tctattggag tctgagttgt ttggtcatga aaaaggttct tttacaggag cagtagatag
    10741 tagaaaaggt agatttgaac tttcgaataa aggaactcta tttttggatg aaataggaga
    10801 tatacctcta aatgttcagg taaaactttt gaggacactt gaggacaaat ctatagagag
    10861 gataggaagt aataaatcta ttaaagttga ctttaggtta atttgtgcta tgaataaaga
    10921 accaaaagtg gaaatatcaa atggaaatat aagagaagat tttttttata gaataagtac
    10981 aataacaata actataccac cgctaagaaa gagaagagaa gacttaacta ctcttataga
    11041 atttttctta aataagtacc aaattgaaca tgataaaaag atacactcga ttgataagga
    11101 agtaaaggat tttttattaa attacaatta tccaggaaat ataagagaat taaaaaatat
    11161 aataaataga cttgtagttt taagtgaaga aggcaattta tcaaaagaca atttaaattt
    11221 aatatcaaat aatgtataca tagatgataa aataagtatt agacctttaa gagaaataag
    11281 aaaagagttt gaatgtgagt atattgaaaa agttttatct ttgtgtggaa ataatatttc
    11341 aaatacagct aaaaaattgg agattagtag aagacagtta accaataaaa tatcagagta
    11401 taatattaag tgagaaaaaa acttctcatt aagtgagaaa aaaatttctc aaactgtatt
    11461 aaaagataaa cagaaaaaat ctgtttatct ttttttatta taattttaaa aattaatatt
    11521 tacaataatt attgctaaat tcaatattgg tgtaaattaa aaatgaaaat ttctatgaca
    11581 ttaatacata gaatatatat tttaaataat tggcatagaa aatgctttat atattaataa
    11641 acgtaataaa tacttttaat tgcgattaaa tatattaagg gggattttca tatgaagcta
    11701 gagctaggga atatatttat aaaaaatgtt gaatttggag aaaagacaga agtaaaagat
    11761 ggagtactat atattagtag cgaagaaata gaaaagatag tattagaaga tgaaaggatt
    11821 gtaagtgtaa atgttgaact tgcaagacct ggcgaatcaa taagaatagc tccagttaaa
    11881 gatgtaatag agcctagagt taaaattgga gatgaaagca aaatatttcc tggaattata
    11941 aataaagtga agactgtagg aagtggaaga acccatgtac ttttaggagc ttgtgttgta
    12001 acttgtggaa atatagttgg atttcaagaa ggcgtaattg atatgagtgg tcctactgct
    12061 aaatatacac ctttttcaaa aacaaataat atatgtattg ttataaaagc aaaggatggt
    12121 atagatactc atgattatga agaagcagct agaattgcag gattaaaaat aggtgcatat
    12181 gtaggtgagg caggaagaga agttgagcca gatgaagtca ttgtatatga gacaaagcca
    12241 ttattaaaac aagtaaaaga atatccagac ctgccaacag tagcatatgt tcacatgtta
    12301 caatcacaag gacttttaca tgacacttat tactatgggg tggatgctaa acagatagtg
    12361 cctacattta tgtatccaac tgaaataatg gatggagcta taatatctgg aaactgtgta
    12421 gcaccatgtg ataaggttac aacattccat catttaaata atccagttat acatgactta
    12481 tataaaagac atggaaaaga tttaaacttt ataggagtta ttttgactaa tgagaacgta
    12541 ttcttagtcg ataaagagag aagctctgat atggtagcta aattaataga atttttagga
    12601 gttgatggag ttctagtgac agaagaaggt tatgggaatc cagatactga cctaatgatg
    12661 aattgtagaa aatgtagtga agttggagca aatgtagttt tgataacgga tgaatttcct
    12721 ggaaaagatg gcaagagtca atctatagca gacgctacta aggaagcaga tgcagttgtt
    12781 tcttgtggtc aaggaaatct agtggttcat ttcccagcaa tggaaaaaat tataggaact
    12841 ttagattatg ttgaaatgat gataggtggg tataaaggat gcttaaatga agacggaagc
    12901 atggatgcag agctacaaat tataatagca tcaactatag caaatggcta taatcatttg
    12961 acagcaagat attattaaat aagtatttga atataaagtt ctgttgatat aatcattggt
    13021 ctaattgatg taacaactat aaagtgattt ggaggattaa gagatgagta aaatcagagt
    13081 ggttcattat ataaacaatt tctttgctgg tataggtgga gaggaaaaag cagatattcc
    13141 gccagaaaaa agggctggtg tagtaggacc tggaatagca tttcagagtc aatttaatga
    13201 tgatgcagag ataatctcaa ctgtaatttg cggagatacg tattttggtg aaaatattga
    13261 gagtgcaact caagaacttt taaaaatgat aaaagaagaa agccctgatt tatttattgc
    13321 aggcccagca tttaatgcag gtagatatgg agtagcttgt gggactattt gtaaggcagt
    13381 tgaagaagag ttaaatattc ctgtaattac aggcatgtat aaagaaaatc caggtgtaga
    13441 tatgtttaaa ttagatttgc atatagtgtc tacaggaaat tcagcagcaa gtcttagaaa
    13501 ggtagttcca ataatgacaa aactaggtct taaattggtt agaggtgagg aaataggacc
    13561 tcctgaagag gaaggatata taatgagagg aataagaaaa aatttcttcc atgaacttag
    13621 agggtctgaa agagcaattg atatgttggt taaaaagatg aaaggggaaa gctttgaaac
    13681 tgagtatcca atgcctgaat ttgatagagt tacacctatg aaacctgtta aagatttatc
    13741 taagataaaa cttgccctag taacttctgg agggatagtt ccaattgata atccagacaa
    13801 aattgaatct tcaagtgcta ctaaatatgg aatttacgat ttaacagata tggattctat
    13861 gtcaaataaa gaatttacaa ctatacatgg ggggtatgac agagcatatg tccttgaaaa
    13921 tccaaattta gttgtaccac tagatgtagt tagagagctt gaaaaagaag gtgtaattgg
    13981 agaattagta gattatttta taactactac aggaacagga acgagtgttg gcaattctaa
    14041 gagatttgga gaagagtttt ctaaaaaatt gttagaagat gatgtagatg ctgtaatttt
    14101 aacttctaca tgaggtactt gtactcgttg tggagcaacg atggtaaaag agattgagag
    14161 agctggtata gcagttgttc atatatgtac agtagtacca atatcactta caataggagc
    14221 taatagaatt gttccagcag tagggatacc atatccactt ggaaatccta tgttaggaga
    14281 agaggaaagt aaaaaaatta gaaagaatat agttttaaaa gctttaaatg cactaacaga
    14341 agatatagaa gaacaaacag tatttgaata ataaaaatac aacacaacac tgaaataaaa
    14401 aaagatatca aaaaataatt ttttaaaatt attttacgat atcttttttt tattaggtaa
    14461 attcgaaatt tgcatttttt aaaattaaat ttataaaagt gataaattag tttattataa
    14521 tattgataca caaattcaaa ttagatatac tatgaaaagc gagattatta cattttggaa
    14581 caaatattca acatattaga tcatattaat tgaacagaaa aaattaactt tatataataa
    14641 ttagaataat gataagaaag aaggtgtata tattgatttc aattgccatt tgtgatgatg
    14701 aatcctatat gctaaatcat ttaaaggaaa atatagaatt atacatgaag cagaagaatt
    14761 tattatataa tatagagctt tttaataaag tagaagattt actatgcaat catgaaaagt
    14821 ttaatattgt atttttagat atacagatgg aagagattaa cggaatgcag gcagctagaa
    14881 aattaaggtc atatggtaat gagtgcttta taattttcgt tacagtttta aatgaatttg
    14941 tatttgatgc ttttgaagta gatgctataa attatctgat aaaacctcta tctaatgaga
    15001 aactatataa aactttggat aaaatagtta caaaacttga tgataatgaa agtaattata
    15061 tcacaataca aaaaggttat tcatattgga aattaaaact tgctgatatt ttatattgtg
    15121 aagttataaa aagaaagatt tatgttcatt taaagaaaga gactgtagat tattatgaga
    15181 ctattgaaaa tttagagaga agtttaccaa caaatttttt taggtgtcat cgtagttata
    15241 taatcaattt acaatatgta tatggatatg aaaatggtaa tgcagttatg gaaagtggag
    15301 atagaatacc tgtttctaga ctacgtcaac aaatattttc aaaagttatg cttgagttca
    15361 tgaaaaatag gaggatataa gatgattaat ttattttctt ccgatttatt tttaaagtac
    15421 agttttttat tttcttttat tgtatataga attttaatgg taatagtgca atactatttt
    15481 ctaatcagtt ttacaaatgt taattcaaaa ttttggtgtt ttattttata ttcgataatt
    15541 tcaatttttt taatcattat aaatacatat tttaatttat ataatttatt ttcttcacag
    15601 attctatttt ttcttatgac ttttttattt gtaaagtaca taataaaaca atctactgtt
    15661 ttatctatag tatcaacttt gttagtatat ttaattgaac aattagtata tggatttaca
    15721 gctccattaa attacttgat atttactagt gatataaata cagatattta taaatttgat
    15781 ataaatatgg gactatcttc tttaattact attataatag ctggatttat atattggtat
    15841 agttctaaaa agtttaatat taaggtcatg aactttgata aatatatagc aattttgatg
    15901 attccattgt tgcttataat attatttatg caatcatttg aatatagttc aaatataaat
    15961 atagatacaa gtcttgggat tgtaaagctg ctattaaata cttctataac tgaagaaatt
    16021 caagcttttc ttttttctat aattggaact atatgtgtat ttttttctct atttaccttt
    16081 aagaaactaa ttcaagctct cgaagatgac aaggagaggg caattatgaa tcaacagatt
    16141 catgctcaaa aaaactatat tgaagaagcg aaatcacgat tatcacaaac tatatccttt
    16201 agacatgatt ttaataatca tttagctatt gtcaatggat tgttgaaaaa agaccaaatt
    16261 ttaaaagcac aagattattt aaataagctt gaaaaagtaa caagtgacct atcattttct
    16321 tgtaatacac agaatattgt tattgatgct cttttcaaca ataaattaag tatagcaaaa
    16381 caattaggca tagaggtaga ttgtgaagta attatacccc aaagcactaa catgaacgat
    16441 tttgacctat gtatagtgtt tgctaatgct attgacaatg caattaaagc ttgtagagtt
    16501 gtagataaac aaaataggta tttaaagctt tccactaagt tagagggtgg attttttatg
    16561 atagaaataa aaaatagcta taatccaata aataattata caagtggctc aggtataggt
    16621 cttttaaata taaaagaaat tgctaaaaaa tatcaagggg ctataagtat agataagaca
    16681 tcagattatt ttcaaataaa tgtattgctg gttatttcat tacattgcgc tagtatttga
    16741 taacaatttc attgaaaata gtatttgtaa gctatattat gtacttgaat agagaaagtt
    16801 tgatatatag aaatgaggag gttactaaaa tgaaagttgg aaatataaat ggtcaagcac
    16861 caattacaaa tggtttagat agttgtcaaa gtgaggtaca aggcttagaa caaaagaaaa
    16921 aatcattaca ggatgaaata gagaaagtaa gaagtgataa aagtattgat ggtgaaacag
    16981 ccaaattaaa aatagaagct ttaaaaaaag aaatggaaga gattgaaaat aaaattcaag
    17041 agttaaaagg aaataaagca aaaaaaacaa ataaagaaga aaataatgtt tcagaagtaa
    17101 ataataatct attagagaga aaaaaagaac cttctaataa tgaaaatgta aaacaattat
    17161 atgatgtttt tgaaagaagc aatgtagacg aacaatggga taatacttat cgtgttctcc
    17221 aagatgataa aaacttaaaa gtaaaattta atagacctat atagtttatt tataaaaata
    17281 gttaatattt taattatcac cactttttag aagaatacac actttatttt aaagacccac
    17341 atatttattt acagttagca catttatatg tggttttata actattattt acaagtctat
    17401 attgataact tttacatagt atataatgtt taaatactta ttcaaattta tctatacata
    17461 aacaaaaaaa gagattttaa aatctctttt tagattgttg acttatggct ttttgattta
    17521 ataaaatcaa gaagccgttt gaattttatc tgttggctga tacccttctg atattgaaac
    17581 accatttttg tttccaaaat cgtttaaaat taagaactta ttatgaatga ctatttcatt
    17641 atgaacaata agcagataac atgaatcttc aatcaatgtt ttaacagtag cattaaatgc
    17701 ttgcttatac agttctatcg tttgtttgaa ctgtccatta aagtaaatat gagtcaataa
    17761 cataactata tctacacaaa ttaatataaa ttttttatac tgtacattat ctaactgttg
    17821 attatctgta ttacaacatg attgaattta aaaagccatc aacacataga atgttgatgg
    17881 cctgaaaata gatttaaaat ctctttttta ttatatatta attatttttt aaatttatat
    17941 tttttgcatc agattttcta atagctaagt caaaccctct aaatctaatc actatagggt
    18001 cattaagagg agctatcttt ttcacttcaa cttcagtgcc atctattagt cctaaggcta
    18061 gaagtctctt cataagtttt tcatttccag ctatattgtc tataattccc ttttgtccaa
    18121 gttttaagtt gtaaacagtc attattaaca cctcctaatg aaaatcatta tcaaacttta
    18181 tatttataat atataacaaa aagagcaaat tgtcaatata taacaaaaaa taaacatact
    18241 aagttagtat gtttataaaa aatagtatac atgggatact aatagcatct agcaaaaaac
    18301 cacttactaa tggtacaact aaaaaggctt ttggagaatc accatatttt tgtgtcaaag
    18361 aactcatatt tgccagagcg ttcggagtag ctcctattcc atgtccaatc aaaccactta
    18421 ttatgatggc agaatcaaaa tcttttccaa gtactctaaa gcaaataaat attgaaaata
    18481 ggattataaa gattacttga aaagttacta ttaagagaat aggaggtaat aatgtagata
    18541 attcaaataa atctatattc ataagtgata aagttaaaaa aattcccaat gaaagttctt
    18601 ttaaaaaatc tataagttta aaatttaatt ctagtatatt tatcttatca tttaaatttc
    18661 taaaaataac agccgaaaac atacaagtta caacagaggg taatagtata ttaaacgtta
    18721 tatagaagca tctacttata atttctcctg tatttataca aataaatatg agaagaacct
    18781 gttccaaaaa tacagatggt gttattgttt cggagaagtt attatttttt atcctattct
    18841 tatttctaaa aaatttactt ccaaatctct ttagatttct attatatcta ggaatcgaca
    18901 agtctatatt tgatgatggt tttaatttat atttatttat tagaaattta gctacaggac
    18961 atcccaatat accacccata ataagtccta ttgttgcagc agataatcca accccaactg
    19021 ctccttctat accgagattt tctattgtaa gtccaaatgc agcagaataa ccatgaccac
    19081 cttccataga tacatttcca cacataagcc ctaaaagagg ttcaagtttt ataatctttg
    19141 atattgtaat agctaatata ttttgacaaa atgccaatac tccacacaaa atccaatatc
    19201 taaataatac actaccacct ttctttataa gatttatgct tatttcaagt cctatagttg
    19261 taaaaaagaa ggttatgaaa tttggcatta aatttccact tatagatata tctgctatat
    19321 taaaatattt aaaaaataaa tttagaaaac aaaataatag acctcctatt actggtgcag
    19381 gtatacagaa attatttaaa aagttaactt tattcttcaa taaattacca attaaaaaga
    19441 agaatataga tagtgtcaag gtttgcacta tatcaaaact taaggtaatc aaaataagtc
    19501 ctcctttgta attcaaagtt ttaattatat aacttaaatt cttatgtatt gaaattttat
    19561 tatcaaatgt atattaataa atgtatatta aaaagaatca gtagatataa ttagatagtc
    19621 ataaattaaa ttaaaatatt ttaatgagat atgacttttt tagaattaaa aaccgtagta
    19681 tattgatata atagaaataa gacttaaaaa tctgttgata gtattattta taagtacagt
    19741 aggaggataa aatgtttgaa aatttaccta agatagattt acattgccac ttagatggaa
    19801 gtgttagagt agaaaccatg cttgatatag ctattaaaga gaaaatagat ttaccttcaa
    19861 ataatatgga tgaaataaaa aaattagcaa aggtttcttt taattgtact tcactagatg
    19921 aatatttaga aaaatttgat ttacccttaa aagtaatgca atctaaggaa aatttaaaaa
    19981 gaattacttt tgaacttttg gaagatgcaa gtagagaaaa tgtaaaatat attgaaatta
    20041 gatttgcacc attacttcac acccaaaaag gtatgagtgt taaaaatata attgagggta
    20101 taattgaagg aattagagaa gctgaaagta tttatgatat aaaaggcaat ttaatattag
    20161 gttgtatgag aacaatgacc tcaaaagagg cattattagt aattgaagaa gggaaatcat
    20221 ttgtaaataa aggtgttgta gcagtagact tgtgtggtcc agagaaagag ggattttgta
    20281 aggaatataa agatgttttt aaattagcaa gagaatatgg atataaagtt acaatacatg
    20341 caggagaagc tgcaagtgga gaaaatgtat tggatgctat aaatatttta aaggcggata
    20401 ggattggtca tggggtaaaa attaaagacc ataaaaaggc gtataattta gttaaagata
    20461 aaaaaatatt gcttgaatta tgtccaacta gtaatgtaca aactaagaca gtagattctt
    20521 atgaagcaca tccattttat actttttata aagataattt acatgtaagt ataaatactg
    20581 ataatagaac tgtatcagat ataaatttaa gttcagaact aaatgttata tttgatactt
    20641 ttaaactagg attagaagac tataaaataa tttatagaaa tgcagtagaa gctagttttg
    20701 cagataaaga aactaaagag tatttgaata gtttaattta atagataaaa atatttaaac
    20761 tttaaattaa gctattaaat tgataaaaat acattgtatt aggagaaaaa atgtgaaaga
    20821 ttatgaagat gttgtttata ttaaactagt caaaaaagaa cttgaagaat ggaagaaaaa
    20881 tatattaaag aaaccttcta tatttgacaa agcatcaaag ggtatacaga ataaatttaa
    20941 tggagtattg ccagataaat atcatgaaat aattacttct tctataaaag taatgacaaa
    21001 aaccgtactg tttggatata aatatgctac aaagccacca cttagaaata tgtcattaga
    21061 agaaagagaa aaattagttt tagaaaaagc taaaacttac aagactacag caatgattga
    21121 aggggcagga acaggggcag gaggaatcct cttaggttta tctgattttc ctttgctttt
    21181 aggtattaaa gtgaaatttt tatatgatgt agcttcaata tatggatatg atgttaaaga
    21241 ttatagagaa aggatttata tattaaatat attacagttg gctttttcta gtcaacagca
    21301 tataaacaaa acttttaaat tgatgaataa ctgggatgaa tatgtaaata gtctaccaga
    21361 agacatcaat gattttgatt ggagaacatt tcaacaagag tatagggatt atttagattt
    21421 agctaagttt ttacaactaa tgcctggaat aggagcattt gtaggatttt atgtgaatgg
    21481 aaaattaatt gataaattat gtgaaactgc tgtgtctgct tatagattga ggattcgaga
    21541 gcttaagtta taagaaaaat tataacataa aaaattagtt atacaatata tctatatgta
    21601 tctaattttg cattgataaa aacaattatg gataaaaggt aaagcatgat agaatctaat
    21661 gtagaggttt gtattttaat ggaaaaattt agtttttatt gcttaagata caaattgaat
    21721 tacgaagaga ttgaattatg aagagaagta attgggagga atattttcat gacaaatttg
    21781 ccaaaacaat ttgatagctt caatgaagct agacaaaaag gatttataaa tgcaaaggaa
    21841 cttaaggaaa gtgggaaaaa gatggttgga gttttctgta catttactcc agttgaaatt
    21901 ccaatggcag ctggagcaac tgtagtaggt gtatgcggcg ttagtgaaga gccaatacct
    21961 gatgcagaaa gggtgcttcc aagaaatctt tgtcctttaa ttaaatcaag ctatggacat
    22021 gcaataacag atacctgtcc ttatttctat ttttctgatt tgttgatagg agaaaccact
    22081 tgtgatggta agaaaaaaat gtatgaagaa cttgcaaaag ttaagccaac atatgtaatg
    22141 catttgccaa atacttcaaa aggagaattt gcctataaac tttggaaaga tgaaatgata
    22201 agattaaaag aagaggttga gaaatcttta ggtgtaacta taactgaaga agatataaga
    22261 actgctataa aagataaaaa tgaagaaaga gaacttttaa aagagtttta tgcacttggt
    22321 aaattacaac catctgcact tacaggcctt gagttacata atgttttata tcaagcaggt
    22381 tttaaatttg accgtgcaga acttaaacat tctttaagaa aagttataga tgatatgaaa
    22441 gaaagatatg aaaaaggtga atgtcctgtt caaaaagata agccaagaat attgataaca
    22501 ggttctccta ttggtggaat aagcgaaaaa atagttaaaa ctttagaaga tgcaggggca
    22561 tcagtcgttg catatgaact ttgtggagct attagatcaa acgatttatt ggttgatgaa
    22621 gaaatagaag atgtatatga tgctttaaca caaaaatata taaatatagg ttgttcttgt
    22681 atgatgaata atgacaatcg tattgaatta ttagatagaa taatagatga atataatgta
    22741 gatgctgtaa tagatgtagt tttacaagca tgtcatacat ttaatataga aagttataga
    22801 ataagagaat ttgttacaaa agaaaaaaat aagccattta tgtctcttga aactgattat
    22861 tcaaaatcag atactgaaca attaagaact agatttgaag cgtttgtaga gatgttgtag
    22921 gaataaataa aagtaggagg aactatgttt agtataggag ttgactcagg gtcagtggca
    22981 acaaagggtg tgctatttga tggtgaaaaa attattaaga aaataattat accaactgga
    23041 tggagcccta aaagtacatc taaacaggtc tatgagttgc taagtagtga aattgacaaa
    23101 aaagatataa aaaaggtggt aggtacaggt tatggaaggg gagtaatgga ttttgctgat
    23161 aagaaagtaa cagaaataac ttgtcatact agaggtattt actttttaaa caagaacata
    23221 aggactattt tagatgtagg tggtcaagat agtaaagtta taaatttaga tagagatgga
    23281 aatgtattta actttataat gaatgataag tgtgctgcag gaactggtcg atttttagag
    23341 attacttcta accttttagg aagcgatatt gaaagtatag atacattagc taaaggatat
    23401 gaaccagtta atatatctag tatgtgtaca gtttttgctg agtctgaaat tgtaagtctt
    23461 ctagctcaaa acatttctac tggagaggta gcagcaggga tacttaaatc tattgcaaat
    23521 aaatccacct caatgttagc aagaggtgag gtaatagatg aagttgcatt tactggaggg
    23581 cttgcaaaaa gtaaagaact agtaaaaatg atagaagaaa tactgggtaa aaaaattttt
    23641 attgcagaag atactcaaat aataggagct ttaggagctg ctgtaatagg atttagataa
    23701 aaacatataa aaagaaaatg agaagctgaa tttattataa ataaattcag ttttttattt
    23761 tattttattt atttataaag gaaaactttg gtataattga tttaaatgat tgtatatttg
    23821 taaatacttg atatttagtc atatataaca ttataatttt aaaaattagc tcaaaataag
    23881 ggggagaaag cgtgaaaaaa tttacttcaa aaaaagtaac aaggtttgtt gcgctgtttt
    23941 taatatctat tttagtaatg tcaacaattc ctgtatcagc tgacaatagc aatacattga
    24001 atcagataaa aaaagcagaa tacagtgaga cgtataaaca atatctaaat gatgctaaaa
    24061 atggatgtac agaaaaatat aatgggatta taccaaatcc atatcagttg gaaggtactc
    24121 aaatccaaag taaaggaaga acagctccaa catcttatga ccctagaaaa ttaggtctta
    24181 tgacatcaat aaaaaatcaa gaggatttag gaatctgttg ggattttgct gcaatggcaa
    24241 ccttagaaag tttcttaaag ttaaataatt atggagacta tgatttatca gaagaacact
    24301 taagatggtg ggcttcagat ggtgaatatg gatggtctgt aaatgatatg aatggtgctt
    24361 taaattatga agctatggga tatttaacat cttggtcagg tcctaaatta gaaaaagata
    24421 tcccatacaa tggtagagta tctaaagcac aaggagcaaa aaaaccaact aatatgaata
    24481 cagcacctac tgtttttaat gtgacagatg ctgtgtgtgt aagcaatgac ataaattcta
    24541 caaaaaatgc tatattacag tatggagctg taacatctgg ttattatgaa gatattaaat
    24601 atcaaagtga tgaccaaaat tcatattatt gtccaacaaa aagttttaat acaaatcatg
    24661 ctatttcaat tgtaggttgg gatgataact attctaaaga taattttaat gcaaatatta
    24721 gaccatcaaa aaatggtgct tggttaataa aaaatagctg gggagattat aattctgagg
    24781 gtggatattt ctggatatct tatgaagaca agacacttat gtctgatata gataattttt
    24841 caatcaaagg tggtaaaaaa ccaaatgatg atgagaagat gtatcaacat gactatgcaa
    24901 gtattgtacc tttaatttca aaaaagataa cagctgcaaa tgtatttgat ttcaatagag
    24961 gcgatgaaac tctaaaatct gtaatgttct taactgaaag tataggagct aagtatgaag
    25021 tatattatgc tccagtagta aatggtatac ctcaagaaaa caatatgaaa aaattaaaag
    25081 aaggtactgc ccaatattca ggatacataa cagttccaat tgattctttt gatataccag
    25141 aaggaaaggg tgcaattgta gtcagtatag aggggaaaaa tggagagtca actataggtt
    25201 ctgagtcaaa tgtaccagga tatgatacat ttaaagcaaa agctaattta ggtgaaagtt
    25261 atatcataga taatactgga aaattctttg atataaatag agatagtaac ttctatccgt
    25321 gtaattttac tataaaagct gttacagaaa agtcttctgg tgagagtatc ccaaatgagt
    25381 ctttaattgg tagtgataga tatgaaactg ctatcaaagt tagtcaaaat ggtttcaatt
    25441 cttcagaaaa tgtagtttta gtaaatggca gttcaatagt agatgcattg gcagcaactc
    25501 cttttacatc tgctataaat tcaccaatat tattgacaca aaaagaagct ttaaattcaa
    25561 aaactaaagc tgagatacag agattaggtg ctaagaaagt atacctaata ggtggagaaa
    25621 attctataag taaagaaatt gaacaacaat taaaaagctt aaatatatcg atagagagaa
    25681 tatcaggaag tgatagatac aagacaagtt tattattagc tcaaaagtta aatggtataa
    25741 aaaatgtatc tcaaatagca gttgtaaatg gagtgaaagg attagctgat gcaattagtg
    25801 taggcgctgc agcagcagaa aataacatac caatcatact tgcaaatgaa aagagcgaat
    25861 tgcaaggagc tgatgaattt ctaaattcat taaatataga gaaatcttat attattggag
    25921 gaacagcatc cctatcaaac aatctagaaa gtaagttaaa aaatccaact agattatctg
    25981 gtagtagtag agacgaaact aattcaaaga taatagataa tttttataaa aaagatactt
    26041 taaaaaatgc atttgtagtt aaaaatggaa tcaagaatca aaatgattta atagatggat
    26101 tggcagttgg tcctttagga gcaaaaactg ggtcaccagt aattttagtt ggtgataaat
    26161 tagctgatag ccaaaaagaa gttcttaaaa ataagacttt agaaaaagta actcaagttg
    26221 gtggaggagc aaataaaaat gcatttaaag agttagtaaa attaaaaagt gctaaataga
    26281 gtacttaagt attaacatat attagtgtgt attagtaact tatcttaata aaagctgaaa
    26341 ataattactt caaattattg ataaataaga taatcaatga ttgtaaagtt ttgttttcag
    26401 ctttaaattt atgtagtata agtttaaaaa cataaaaaag ggttacttta tatagaaata
    26461 tagaaaatct tacattttat atataaataa cccatattta attaactttt tatagtgttc
    26521 taatagatat tattgaactt aatggtaaat ataatgtgta agtttcattt aaagttggat
    26581 tagattcatc tatatatctt gagcaaagtg taattgataa gctatctgct tctataattt
    26641 caccatatag aggacaactg ctaaagtaag aatgtacttc aacatattta tttaagtttt
    26701 cttgaacata atcgtaaaaa cggttttttg tagtagtagc cataaaatca actcctttat
    26761 tttttattaa agttgaaact tttaaaaaga taaatatgat tacttctatt agaaactaag
    26821 ttaaaaaata agcaaataga tatgaaaatt agaataatat attatttata tcttaattat
    26881 aacactagat aataaaaaat gctatataaa attcagaatt ttcgaaagtt tttaagctta
    26941 tttttaaata tactaataat actattgaca ttagatagaa aaagtattat attgactata
    27001 taaattattt tagtcaaact ggagggaaaa gatgcctaaa tcatattctg ataaagaaag
    27061 agagtatata ataaaaagac ttaaagaaga agcaagattg tgtatggagc aatatggtat
    27121 tagaaaaact actgttgatg agcttgtaaa acgggtaaaa ataccaaaag gaacttttta
    27181 tctatttttt caatcaaaag aattactctt ttttgaggta ttaagagata tacatgactc
    27241 tatacaaaaa gaaatcttat atgagataaa tagagtagat gaaagtatta catgtgaaca
    27301 attgacagat atatttatga aattctatag gatggttgat agtacttcaa ttttaaatct
    27361 catgataaat ggagaatttg agatattggt gagaaagtta ccagattcta taattgaaga
    27421 atactttaga catgatgact ttgaaattgg agagattata tcttgcatac caaatgcaaa
    27481 aaataaagac atagaaagct ttagtggagc atttagagca gtttttctta ccatgctata
    27541 taagcgcgag gttggaagta attgttttga agatgcttta agattaatga taaacggatt
    27601 agttatacaa cttatggaat agaatttaaa ttttgtttgc taataacttt tattaaaaat
    27661 tattaacaaa caaaaaaatt atattttatt gaccatatag tcaaaatagt caaaaatttg
    27721 aaagggtgat attgaatgat taaagttgat gatttatcat ttagttatac agatagagat
    27781 tttttacaaa atattaactt tgaagtagga aaaggggaaa tactaggatt tttaggacca
    27841 tcaggtgcag gaaaatctac attacaaaag attctaattg gaatgataac taattatgga
    27901 ggaagtgtca ttgtaaatgg agtagagagt aaaagacact caaataaatt ttatgaaaat
    27961 ataggagttg attttgaatt tcctagttta tatgaaaagt tgactgcaat agaaaattta
    28021 aaatattttg ggtctctata ttctaaaaaa ctactatcta ttgatgagtt attaaaatca
    28081 gtaggactag aaaatgaatc aaataaaagg gtatctgagt attcaaaagg tatgaaatct
    28141 cgattaaatt ttataaaagc tttattacat aatccagata ttttattttt agatgaacca
    28201 acaagtggtc ttgacccatc aaatagcaag gttatgaaag atataatttt atcagaaaaa
    28261 tcgaaaggta agactattat tttaacaact cataacatgt tagatgcaac agagctttgt
    28321 gacagagtag cgttcattgt aaatggtaaa atatctgctt tagatacacc acataatctt
    28381 attatgtcaa aaggagctat taaagttaga tatacttact ttgataatgg agaaaaaact
    28441 tctgaatgtt ttctgaacaa tactgctaat gataaaaatt tgaatatgct tattgagaaa
    28501 aataaacttt tatcaataca tagtagtgaa ccaacattaa atgatatttt tattgagata
    28561 acagggagga atttacaatg aggctaaaaa atcttatttt aggagatata aagtttcaat
    28621 ttaagtatgg tttttatttt ttatatcttt ttttaagtat tatatatatt tgtattatca
    28681 atgtatttcc aacttttatg agagaaaaaa tagctataat tatgatttat tctgacccag
    28741 cagcaatggg attgtttttt atgggagcta ttgtacttct tgagaaaagt caaagggttt
    28801 taaattcctt agctgtatct ccagtaaaag tatctgagta tattttatca aaggtaattt
    28861 cattaggagt aatatctagt attgtagcta tgtttattgc tattacatta aatttagata
    28921 atattataat atcaactata ggtacctttt tttcttctat tatattttct ttgcttggat
    28981 tgataattgc aagtaaagca tctagtttga atcagtttat tgttttaagt attcctattg
    29041 agattatatg ctttattcca ccaatactga atgtacttct tgacacaaaa tcatatgcaa
    29101 atttgtaccc ttttaatata tgtatttctc ttattagtgg agataaaaat tttataatga
    29161 ttaatatttt aattttaata tcaattataa taataattta ttttataact tattatttta
    29221 tttgtagcag ttggaaaaag gtaggtggag taaaactatg ataaagatta taaatgcgtt
    29281 taaacaagag tttgaacaaa ttaagagaga tgctatgctt tttatagtat gtgtttctcc
    29341 aatattatgt ggagtattta taaaatttgg aataccatta atacagaata tatcacttaa
    29401 caagttttat tatcaattaa atttagagcc gtatttcttg atgtttgatt tacttttagc
    29461 ttttattaca ccttttatgt tcttttttgc ttctacaatg gtcatattgg gagaaattga
    29521 tgacagcatt tcaagatatt taatagtaac tccgcttggt aaaactggtt atcttatttc
    29581 acgatttgga ataccaggta tcttagcatt tattattact atgattctac ttatcttttt
    29641 ttctctaact aaaatttctc tcttgttaaa cttatcaatt tctttattag ttttattaca
    29701 aggagttatt atatcaatat tagtgatttc tttatcatca aataaactag aaggaatggt
    29761 aattacgaaa ttctcaggtg tttttatgat gggtatttta gcaccatttt ttattttaaa
    29821 taaagcacaa tatattctgt tcttcttacc aactttttgg atatcgaagg catttaagga
    29881 agataattat gtctatatgt ttatttcaat tgttatatca ttaatatgga ttttattatt
    29941 atttaaaaag tttagtaaaa aaatagttaa ataagaaaat ttaatatata aatgtaaggt
    30001 tgacttgaca gtaatgttga aaaatgttac atttaagatg taaagttaac cttacatgaa
    30061 tggagcaaat atgaaaaata aaataaagat attaagagaa aaattaggat tgacacaaga
    30121 acaactaggg agattagttg gaacatctag acaggctata aatgctatag aaactggtaa
    30181 aaatgaacct tcaatatggt tggcatatga tatttcaaga atttttaatg aaccaattga
    30241 aagtgtattt ttatttgaag aaagtgaaag aaaatcaaga gcacagataa gtaggggaga
    30301 atattatggc tataagaaag ataagaacat ttgatgatga aattttaaga aaaaagagta
    30361 agtatgtaga aaacgtagat aataagataa gagaaatatt aaatgacatg gcagagacca
    30421 tgtacaatac tccaaatgga ggaggattag ctgcatgcca agtaggagta ttaaagcgat
    30481 tagttgttat agatttagga gaaggactta ttaagcttgt taatcctgaa attattgaac
    30541 aagaagggga acaaattgtt gttgaaggat gtttaagttt tcctgaagta tggggtaaat
    30601 taaaaagacc aaaaaaagtt acagtgcaag ctctaaacga atacggtgag aaaatagaaa
    30661 ttaaaggttc aggttttatg gcaaaatgtc tttgtcatga gatagaccat ttaaatggta
    30721 tagtttttac agataaaatt attgaacatg taaaattgta agatagattg gttattgaat
    30781 ttataaaata ttttatagta aggagttaaa ttatgagatt atggcataag gatttaattg
    30841 atgtattacc taaaaatcaa ttagtaagtc aatggagaga gctacttgct ataaaaggtt
    30901 ctatagataa aaaaggtact ccaaaccatc tattagtgaa taaagtattg aattatagta
    30961 tagatgaatt taaattttat acaaaaattg tacatgatga aatgttaaaa agaaattata
    31021 aacctaatga acttaaatat acaagtatat taaaatggaa aaatagaaat tttgcaaatg
    31081 atatatctaa tgaacatagt ttaaatttag aaaatttata tgatgattgg cataataaaa
    31141 tgtatttaaa gcaatgctta tataatttag aagaaaaagc aacatgtgga ggaataccaa
    31201 taaatgaatg gaatatatta ctttgtaaat atagtaaaga ttatgaattg tggtctggaa
    31261 atatcatgtt ttaattacta tagattaaca ttatagtatt attgtatata aagaggtgat
    31321 tatttgtata ataaaata
//
LOCUS       DAEPID010000045        30244 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.045, whole genome shotgun sequence.
ACCESSION   DAEPID010000045 DAEPID010000000
VERSION     DAEPID010000045.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 30244)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 30244)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..30244
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.045"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            267..1100
                     /locus_tag="KR257_002296"
     CDS             267..1100
                     /locus_tag="KR257_002296"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902571.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="polysaccharide deacetylase"
                     /protein_id="HBH0030980.1"
                     /translation="MRNKKKKINRKKLYLLLSAIVVCLAFIVVGVRVSSLNMKENEIS
                     RNAKLSSSTITDIVSNTSIEVSKGPSKSSGKIAYITIDDGPSKFTDEMIKTLNKYNVK
                     ATFFMIDGNMKEYPQQVKNIIKNGNTAGFHSVSHDIHKLYVTSTSAKEEFDTNDQTFY
                     KITGKHSKVIRIPYGSKPYTPQASYQALVDAGYKIWDWDLDTEDWRSNSSQIVQNVKN
                     HIKNRKGEDKDQLVVLMHEKKQSAEALDSVLKFLSDEGYEFAPVDQNQIPKNYWLRNL
                     E"
     gene            1193..2125
                     /locus_tag="KR257_002297"
     CDS             1193..2125
                     /locus_tag="KR257_002297"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012816146.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptidylprolyl isomerase"
                     /protein_id="HBH0030981.1"
                     /translation="MVGILSLMMVGCNKSLAKVNDVEITKEQYKKTKAVLSATNNYIN
                     GQSLDELEKTLDKKGRNKLENVIISFMVDNELLYQEAKDKGLTPSKSEVDSKYQELED
                     KMNLNTSYKEKMDKAGVDKDYLKQEISRDLAIDKNKKAFEDRINISDNDMEAYYTSHK
                     KDFNVEEVSASQILISTLDKNKKEVSKDKKEALKKKADNILTKIKNGESFESLAKKYS
                     DDKATGKNGGQLGYFTKDDKNAEFTKEVFKLKKNEVSNVFETSYGYHIVKVTDKRERQ
                     KSFNECQSLIRESILNEKYIEHIKKLNEDAKIDR"
     gene            2177..2659
                     /locus_tag="KR257_002298"
     CDS             2177..2659
                     /locus_tag="KR257_002298"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436663.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sigma-70 family RNA polymerase sigma factor"
                     /protein_id="HBH0030982.1"
                     /translation="MFKSLKRTKVEKYIIDNKDSFYRIAYSYTKNEEDALDVVQEAMY
                     KALYSVENIKEVNYIKTWFYKILVRTSIDFIRKNRKYNNMTDIDLIDETGEYDKYTDL
                     DLRRALEELPIEYKSIIILRFFEDLKIEEVAIILDENVNTVKTRLYTALKKLKLKIEE
                     "
     gene            2671..3540
                     /locus_tag="KR257_002299"
     CDS             2671..3540
                     /locus_tag="KR257_002299"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728549.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3298 domain-containing protein"
                     /protein_id="HBH0030983.1"
                     /translation="MTSKERLNKLKDEYHKIPIPKKLDTIINHEKIENIYREKNKKVN
                     RLRFKVAIAFACIFTVLVNISPVFADNFSKIPVIGAIVEVITIKNYSLKSENYEAEID
                     IPKIRGLKDKNLEQRLNSSFMEDGKRLYHQFQERMEKIQSSKNKGYKSLSLSYSVKNN
                     SKKFLSIEMTKNEIEASSYVSKVHYTIDKKRQIVLTLPMLFKDDKYIKVISDNIKEQM
                     REQMKKDSTKSYFIDQKKDLPVEDFKTINKYQDFYFNKNEDLVICFDEYEVAPGYMGA
                     VEFVIPYKVIKDL"
     gene            3583..4338
                     /locus_tag="KR257_002300"
     CDS             3583..4338
                     /locus_tag="KR257_002300"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861251.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3298 domain-containing protein"
                     /protein_id="HBH0030984.1"
                     /translation="MTTYKKLKKSIFKIAIFSICLLVSLVDTNPIFAGSSFNETSNSD
                     TIKVLNAKSINFKQDNYEVNVSIPKIKGLKDKTLENKLNNEFLQDGKKIYSEFQNKMK
                     KENNKGHRYLNVIHNVKNNSKDFLSIEMTKEEIEASSSITKKHYTVDKNRGILLNLPI
                     FFKDSRYIRAISDNIKEQMRNQIKKDDTKSYFIDQDKDSPVKDFESINKYQDFYFNKN
                     GNLVISFDEYEVAPGYMGAVEFVIPNKVIKRLR"
     gene            4380..5201
                     /locus_tag="KR257_002301"
     CDS             4380..5201
                     /locus_tag="KR257_002301"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889422.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="xanthine dehydrogenase accessory factor"
                     /protein_id="HBH0030985.1"
                     /translation="MNIYEQAIRLIENNEDFAFATITSHSGSTPRETGAMMIVKNDST
                     IFGSVGGGSVEAECIKHAINVIKNRESMLYKFTLNKSDVAKLGMICGGTGEIQIDFID
                     SKLKSNIEKFNKRLKENTSKAYIFGAGHISRDVAVILSLLEFRTVVIDDREEFANHER
                     FPESEVVVLDSFENIPDFPTDENSYIIILTRGHLYDSSALEWALKREAGYIGMIGSRT
                     KIGLTYEKLMKKGFKKEELSKVHAPIGIKLNAQTPAEIAVCIAAELINCRANKEK"
     gene            5206..5967
                     /locus_tag="KR257_002302"
     CDS             5206..5967
                     /locus_tag="KR257_002302"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429799.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="M48 family metallopeptidase"
                     /protein_id="HBH0030986.1"
                     /translation="MNTGSKDIDTLKVNFRGIEIKAVLVYKNRKNISIKIDPFGKITV
                     MSPPKISKKIIKDIIIEKGDWILKKSEKCKGREEVYKQRMFITGEKFLYLGEEYHLVI
                     KELLRDSVKKSNCRITINEYQIVVQTNDTSTDFIKKSLKSWYKMESERIVLERIDFLK
                     LNCEIMKQLVPASVKVKEQNKRWGSCTAQKNIYINSKISMARLDVIDYVIIHEFSHLA
                     HMNHSKKFYDLVKSIMPDYKDKENWLKINGYKIII"
     misc_binding    6128..6385
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00230"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="T-box leader; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /bound_moiety="tRNA"
                     /db_xref="RFAM:RF00230"
     gene            6498..6737
                     /locus_tag="KR257_002303"
     CDS             6498..6737
                     /locus_tag="KR257_002303"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429800.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ACT domain-containing protein"
                     /protein_id="HBH0030987.1"
                     /translation="MENTVYAKLNQGIDSFLRVAMTLRRREVDIQSISMTVDNMNNSG
                     IKLIVNEEKTSLDSVLNHMKKLHDIREITVERMRH"
     gene            7041..8036
                     /gene="ilvC"
                     /locus_tag="KR257_002304"
     CDS             7041..8036
                     /gene="ilvC"
                     /locus_tag="KR257_002304"
                     /EC_number="1.1.1.86"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436646.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ketol-acid reductoisomerase"
                     /protein_id="HBH0030988.1"
                     /translation="MKMARMYYEKDVDLEVLKNKKVAVLGYGSQGHAHAQNLRDNGVH
                     VVIGLYDGSKSAQKAKEDGFEVKSVAEATKESDLTMMLMPDEKQKKVYEESVKDNLKE
                     GQTLAFAHGFNIHYNQVQPPEFVDVVMVAPKGPGHLVRNVFTKGSGVPALFAVYQDYT
                     KKATETVLAYAKGIGATRAGVLETTFKEETETDLFGEQSVLCGGISELIKLGYKTLVD
                     AGYQKEVAYFECLHEMKLIVDLIYEGGFERMRYSISDTAEYGDYVSGKRVITDAAKQG
                     MQNVLEDIQNGKFAKAWIKENEEGRENFLKTREEEYNTEIAEVGRNLRSMMSFLK"
     gene            8089..9777
                     /gene="ilvB"
                     /locus_tag="KR257_002305"
     CDS             8089..9777
                     /gene="ilvB"
                     /locus_tag="KR257_002305"
                     /EC_number="2.2.1.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429802.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="biosynthetic-type acetolactate synthase large
                     subunit"
                     /protein_id="HBH0030989.1"
                     /translation="MSGAKVILECLKKEGIDTIFGYPGGAVIPLYDALYDYSDDFKHI
                     RTSHEQGLVHAADGYARSTNTVGVCFTTSGPGATNAITGIATAFMDSSPMVVISGQVP
                     TSLLGKDSFQEIDITGATLSMTKHNYLVRNTKELVPTIKEAFRVANSGRKGPVLVDVP
                     KDLFLAEMDFSGEDYDLCQIDDYMDYKSDFDLDDETNIKLLNEAIDIIKESKKPIIYA
                     GGGVKSSDSEEILEKFATKIDTPVLNTLMGLGNIDRKNELSLGMVGMHGSRESNLALS
                     NSDLVIAIGARFSDRVISKSSEFAKNAKIIHIDIDPSEISKNIESNVSLVGDVKLVLS
                     LLIERVESKNNSNWKEEIKRFRKSEGVQTYEFHPQNILKKINEKYETLKKPTVVVTDV
                     GQHQMWAAKYWNFKGNKSFITSAGLGTMGFGLGAAIGTKVGNVDKNVVLVTGDGSFRM
                     NCNELATVANYNVPMLILLLNNRTLGMVRQWQKLFSNQRYSQTDINENVDYVKLVNAY
                     NIDGYKVSSMEELGKALDMIDFNKPVFLQCDIDKDYDVYPIVAPNDALENLICN"
     gene            complement(10138..11268)
                     /locus_tag="KR257_002306"
     CDS             complement(10138..11268)
                     /locus_tag="KR257_002306"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728553.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="site-specific integrase"
                     /protein_id="HBH0030990.1"
                     /translation="MKGGVRKRSNKWYYYFDLGIVEGKRKKVERVGGNTKKEAEKALR
                     EALNEYENSGIVFEESNISLSDYLDFWYKEYVLLNCKYNTQESYRINIEKHIKPKLGA
                     YKVKALTPAILQNFINRKYKEDYSQNTLQVLKAILHRSLKSAVHPYKHIRENPMQYVS
                     IPKTKSKTETNKIKTITLEEFNQILNIFPQDSFQRIVLLIGFHTGMRRGEIIALKWDN
                     IDLDNKTITVRHTLIKKPNGMFELGQPKTESSCRTIFTGDTLIKALKEHKLYQKKMKL
                     KYGEFYFDSDWVCTKENGQQVNTHTLDTIVRQIRVALNNDFHFHSLRHAHATLLLENG
                     ANIKDIQNRLGHSQLSTTMDTYSHVTDKMKNETVDIFEKITN"
     gene            complement(11508..12014)
                     /locus_tag="KR257_002307"
     CDS             complement(11508..12014)
                     /locus_tag="KR257_002307"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429804.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ImmA/IrrE family metallo-endopeptidase"
                     /protein_id="HBH0030991.1"
                     /translation="MNKLDALLDLANNEEIEIYYTDKIADDIKGLYINRQGLKIISLL
                     NSLKQNNAKLIEILAEELGHHFTSVGNYVSSKNSYKNKILIDKTENKALKWACEFLIT
                     EEEIIHVINSHATSVYEIAEELQVSINFLLKRLEFLSKKKSMLDLGNNRFLVLTNLPN
                     FYIYEDIF"
     gene            complement(12277..13866)
                     /locus_tag="KR257_002308"
     CDS             complement(12277..13866)
                     /locus_tag="KR257_002308"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429805.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SIR2 family protein"
                     /protein_id="HBH0030992.1"
                     /translation="MKSIISDVINRFNATPFLFVGSGLTRRYYNLPNWEDLLKVFAEK
                     ISNDDFIYTSYKNKAKSENPKMGINPRIAELIENDFNKKWFSDSSIRSLDSKYLDIVK
                     SGVSPFKAEIAMYIKNNSKIVDKYQDEVEKLSNISKKSLSGFITTNYDCFLETIVDNY
                     TTYIGQENLVFSSIQGIAEIYKIHGCVSSPNSIVINEADYIDFDSKSAYLAAKLMTIF
                     VEFPIIFIGYSVTDVNIKKILNAIVNCLSNENAKKLEERFIFIEYEKNFNDIEISSHT
                     IVFDNKMITMTKIKLEDFNLLYEALSEKKSKLPVRILRMFKQEFYDFTITNKPTAKIR
                     VGSVDDTRIKDEDLVLAVGKASDFGLKGLKGLSFDEWYRDIVMNDLEFSSDELLEYAY
                     PSLIKQYNKLPLNKHLFNSTLEFPDYRTIALESDFENIISNSIKKNRNNTYIKNRSVY
                     GIWNDEHQSFEKATRLIAFLEEKEIDTEQLENLLKKIFEENPNILESAKTSEKTNLRR
                     LIRIYDYMKYSNMQKSLGYSE"
     gene            complement(13890..14453)
                     /locus_tag="KR257_002309"
     CDS             complement(13890..14453)
                     /locus_tag="KR257_002309"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429806.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="XRE family transcriptional regulator"
                     /protein_id="HBH0030993.1"
                     /translation="MSILSDRLKFLRKEKGVMQKEIANYLNITTSAYGFYEQGKRTPT
                     PEMLSSLAEYFGTTVDYLIGRYDNKASNISSKTSCNNTLFQKRLKELRAEKNMTQEDV
                     ANKLNLTKSAYGYYEQGKTVPDAYMLSSLAEIFNVTTDYLLGRSIVKNDIDTVAAHRV
                     NPHKDLPEEAQEQLNDYIEFLINKYKK"
     gene            14606..14827
                     /locus_tag="KR257_002310"
     CDS             14606..14827
                     /locus_tag="KR257_002310"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429807.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HBH0030994.1"
                     /translation="MNNLKELRTERNLKQKDVALKVGITTSYYGMIESGTRVPSLAIA
                     IKLSKCFGVSIEKIFLNTNTTRCCLKERS"
     gene            14830..15645
                     /locus_tag="KR257_002311"
     CDS             14830..15645
                     /locus_tag="KR257_002311"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902586.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phage regulatory protein/antirepressor Ant"
                     /protein_id="HBH0030995.1"
                     /translation="MKDLKIVKVNNKLTTDSRDIALMVEKEHKILLRDIRNYINQMEE
                     ANKNMSTDLYPSDYFIENTYLDDYKREKPCYAITKIGCDFIANKMTGIKGTAFTGIYT
                     KKFEEMEQVLKNEQPKLPTTYKEALQHLIEQVEVNEKLQLEGKMKDQVIKELKPKADY
                     TDMILKNKGLVTITQIAKDYGMSGKEMNKILHERGIQYKQSGQWLLYKQHQGKGYTHS
                     ETIDITRSDGMTDVKMTTKWTQKGRLFLYDLLKVNNILPDIEKEYSYQTSMLC"
     gene            complement(15824..16003)
                     /locus_tag="KR257_002312"
     CDS             complement(15824..16003)
                     /locus_tag="KR257_002312"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429811.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Arc family DNA-binding protein"
                     /protein_id="HBH0030996.1"
                     /translation="MSTSLPKYTLRINRVLLEKIKYIAESEGRSANKEIEQIIKKHIE
                     DYEQRKGEIKINIEE"
     gene            16139..16318
                     /locus_tag="KR257_002313"
     CDS             16139..16318
                     /locus_tag="KR257_002313"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009901706.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0030997.1"
                     /translation="MNSNKKRITVRMPEKLNEEITKKSKYLGLTKNSFILDILWKEFE
                     LLEYRSYKKEVDKHE"
     gene            16311..17102
                     /locus_tag="KR257_002314"
     CDS             16311..17102
                     /locus_tag="KR257_002314"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009894678.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ORF6N domain-containing protein"
                     /protein_id="HBH0030998.1"
                     /translation="MNNLQVIERNNERVLTTQQLADVYETDSRNISNNFNNNKDKFIE
                     GKHYFLLQGDDLKNFKGIHTEYENLKFASKMYLWTERGANRHCKILDTDKAWEQFDNL
                     EETYFKVKQHKPTCIEDVLIESLKEMKDLRLQVNQANSIALEAKTEVETIKDVVSLDS
                     NSWRTNTHQLIARIAKKQGGFEHINMLRTESYELLNKRFGVDLHRRLINKRRKMAEEG
                     VSESKREKVNNLDVIQDDKKLIEGYVAIVKDMALKYGISSDLSKN"
     gene            complement(17185..17379)
                     /locus_tag="KR257_002315"
     CDS             complement(17185..17379)
                     /locus_tag="KR257_002315"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0030999.1"
                     /translation="MKFVYVKIFNNWIDITDIGSINGCNAIEYINENLDKMYSSNYVS
                     INYKDKNYCIHPSCIQIVTK"
     gene            complement(17535..17753)
                     /locus_tag="KR257_002316"
     CDS             complement(17535..17753)
                     /locus_tag="KR257_002316"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016056353.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HBH0031000.1"
                     /translation="MTKFKDNIKLVRKQMNMTQKQFASLFGISERAYQYYEAGSREPN
                     LETLILISNKLNVSTDFLLGLSPNQNRN"
     gene            17866..18060
                     /locus_tag="KR257_002317"
     CDS             17866..18060
                     /locus_tag="KR257_002317"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016056354.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HBH0031001.1"
                     /translation="MKINNNLKLQREKIGLTQLEVAQKAKITERSYQYYEAGERLPNI
                     RTALKIAIILNTNCEKLFNE"
     gene            18102..18896
                     /locus_tag="KR257_002318"
     CDS             18102..18896
                     /locus_tag="KR257_002318"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015994369.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phage antirepressor KilAC domain-containing
                     protein"
                     /protein_id="HBH0031002.1"
                     /translation="MNNLQLNNKNTITTLEIADMLEIRHWEVLRKLEGTEKTKGIIDI
                     LNDNNFVVVDYFIKSTYLDSKNESRPCYNVTKLGCDFLANKFTGEKGIIFTARYVRRF
                     NEMERVLKEQQPKLPTTYKEALQQLLVEVEEKEQLQLENQEKDKVIQLQQPKVLFADA
                     VSASNNSILVGELAKLIKQNGVDIGQNRLFTWMRENGYLIKRKGEDYNIPTQKSMNLR
                     IMEVKKRVINNPDGSTKVTRTVKITGKGQVYFVNKFKSSKQLSMLS"
     gene            18953..19162
                     /locus_tag="KR257_002319"
     CDS             18953..19162
                     /locus_tag="KR257_002319"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888812.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0031003.1"
                     /translation="MENKKIEEIEKRITMLENQLQAQLFSQITAQSNSDFIDYMYQCI
                     VLYLHEMNKSEKRKISEITKERIRK"
     gene            complement(19172..19546)
                     /locus_tag="KR257_002320"
     CDS             complement(19172..19546)
                     /locus_tag="KR257_002320"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003433505.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0031004.1"
                     /translation="MQFSNNISKELQESIRKTVSDTSNTEYFYYAEFQYKIILKSIEE
                     FEKELDDEHEIALKLTNFGKDVLMIVEEVGYHNPCLIHYYGIVNGVYSEILQHTSQIN
                     FMITSVKKTDPSKPARRIGFIL"
     gene            19622..19819
                     /locus_tag="KR257_002321"
     CDS             19622..19819
                     /locus_tag="KR257_002321"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888813.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HBH0031005.1"
                     /translation="MLIGDNIKQILRKRDIKPYKLAKELNIDVSGLYKLLKNKNSNPT
                     IDTLIKLADYLDITLDELVGR"
     gene            19850..20242
                     /locus_tag="KR257_002322"
     CDS             19850..20242
                     /locus_tag="KR257_002322"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003433509.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="HBH0031006.1"
                     /translation="MDISESITKQFSDSLKSLIEIEINKQETDRVKSQTVEQKVKVLE
                     PKDIVVLIKRGYPNYLITVEEARGILKLDTVFMRRLVSTGLIKSLARGDGRKISRYEV
                     DDFIERNQGKNLDELLKVAERGDEIVKP"
     gene            20229..20372
                     /locus_tag="KR257_002323"
     CDS             20229..20372
                     /locus_tag="KR257_002323"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888817.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0031007.1"
                     /translation="MLSLNTNKNNIVTLKKDGKAIADIVFKDIKTGKKISVGVLNKKV
                     LVK"
     gene            20539..20781
                     /locus_tag="KR257_002324"
     CDS             20539..20781
                     /locus_tag="KR257_002324"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009894507.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0031008.1"
                     /translation="MEAARLIAIGQIKQAEKEICKLQGTKNNSSLMWWEAVKFASQNI
                     LEGLEHDIELEASIEFREAMMYQEELEKDRPIDVQI"
     gene            20860..21141
                     /locus_tag="KR257_002325"
     CDS             20860..21141
                     /locus_tag="KR257_002325"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0031009.1"
                     /translation="MKTKNEIIKGLEDRLFLLRFTTVDEVDWDVKFGQISALEFCIDK
                     HRKGCTLEQFKEHLDEYKLQGNYGDYIDGFVSVLERNIREMEGEIDGSE"
     gene            21128..21766
                     /locus_tag="KR257_002326"
     CDS             21128..21766
                     /locus_tag="KR257_002326"
                     /inference="COORDINATES: protein motif:HMM:NF016302.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ERF family protein"
                     /protein_id="HBH0031010.1"
                     /translation="MEVNNIYIKLMDVRIKFNKLDIKKSGQNKFANFKYFELADFLPQ
                     ATELLQEAKLCPIVTFTNDYATLTLINGEKPTEEIIFTSPMRELQLKGSNELQALGGI
                     ETYQTRYLYIQLLNITENDTFDATSGKEDYKRNDLTNSSIKASENGQIKISQNQIKRL
                     FSIGNTIGKDSDRVKSEVYYKFNKEVKDLSKQEYDQICVGYEKLQREKGIIK"
     gene            21776..22671
                     /locus_tag="KR257_002327"
                     /pseudo
     CDS             21776..22671
                     /locus_tag="KR257_002327"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009894692.1"
                     /note="frameshifted; internal stop; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="DnaD domain protein"
     gene            22691..23110
                     /gene="ssb"
                     /locus_tag="KR257_002328"
     CDS             22691..23110
                     /gene="ssb"
                     /locus_tag="KR257_002328"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420524.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="single-stranded DNA-binding protein"
                     /protein_id="HBH0031011.1"
                     /translation="MNQVVLVGRLTRDPELKYIPGTGTAVASFTIAVDRNYINKEGKR
                     DTDFIPIEVIGKSAEYCANYITKGKLVALEGNIRVDNYQTQSGEKRIFTKVSTKSVQS
                     LESKNKSSNSYKESVQDGTIGLDPQGFEIIDDDELPF"
     gene            23140..23502
                     /locus_tag="KR257_002329"
     CDS             23140..23502
                     /locus_tag="KR257_002329"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015994375.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0031012.1"
                     /translation="MFKVERYFSGSVVDNLIEDDLTCRNYLALYCCLLGITKNGKKIY
                     PKPEKMLAEFGVKKDRKIKKELPVRIRNVNTGEVKEFESIDGAACFLRLKYQAVYQAI
                     KKKTKTRSGWKVEYIKEE"
     gene            23736..24587
                     /locus_tag="KR257_002330"
     CDS             23736..24587
                     /locus_tag="KR257_002330"
                     /inference="COORDINATES: protein motif:HMM:NF012372.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA cytosine methyltransferase"
                     /protein_id="HBH0031013.1"
                     /translation="MNVLSLFDGISCGQVAFERARIKVENYFASEIKEIAIKVAMNNY
                     PKTIQLGDVRELNVSKIPKVDILIGGSPCQNLSKGRLIANKIQDGLTGDKSNLFWEYI
                     RILKQLNPEYFLLENVVMPKKDENMISQLLGVEPIKINSNLVSYQNRDRLYWTNILNV
                     QQPKDLKISFQDYKDTSFDYCKEFEIKKTPSREKMWGNGLNGNCKNVTYEDKINCVTL
                     KQDRFSNSGLVEFGSFCRYLTTRELELAQTLPVGYTKGLSIRQAQNVIGDGWTIDVIA
                     HILSNIN"
     gene            24904..25101
                     /locus_tag="KR257_002331"
     CDS             24904..25101
                     /locus_tag="KR257_002331"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009899200.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0031014.1"
                     /translation="MNKFQKAVSQMVKQEEKENLLQGYENCIVGRSISSSIRRYVKGF
                     EKFGYSVHEVYEFINDINKYE"
     gene            25128..25544
                     /locus_tag="KR257_002332"
     CDS             25128..25544
                     /locus_tag="KR257_002332"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003366126.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1064 domain-containing protein"
                     /protein_id="HBH0031015.1"
                     /translation="MSKYNNKKIVIDGIKFDSKDESEYYLYLKEKKENGEIKDFGLQQ
                     KFELQPKFKKDGKSYRAITYTIDFAIYKWNGEVVYIDVKGYSTQQGELRKKLFDYKYQ
                     DKKLIWIAKSKKYGVDGWIEYSELKKKRKENKKKVA"
     gene            25563..26063
                     /locus_tag="KR257_002333"
     CDS             25563..26063
                     /locus_tag="KR257_002333"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016056376.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0031016.1"
                     /translation="MASKVKKEFFMATKKHLENYKQLHINIESLKLQIKNLKEFHLGD
                     FMQGLSYDSIPISKTNSISNQVENELINLEEKIIEKQIELYEMEALKYTIDVSISNLK
                     PIHKQIIRYRYIEGLEWSLIVDKVYLEERQLRERANQAISSISIALFGKKALIEQEPL
                     FKMLDL"
     gene            26485..26691
                     /locus_tag="KR257_002334"
     CDS             26485..26691
                     /locus_tag="KR257_002334"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0031017.1"
                     /translation="MNRFEGIYSFAEATKLWDLKDSTLRKAVATGKLVENIDCKKFGR
                     DWVVTIEAMEREYGKLNNIMKDLD"
     gene            27180..28367
                     /locus_tag="KR257_002335"
     CDS             27180..28367
                     /locus_tag="KR257_002335"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0031018.1"
                     /translation="MLNEKNLKNIKNILQMVQMKHLKDFENWGINKRKKETAINSLIN
                     IIQNDGEKLDYFKEWISIFTIDGHNNYYVFNYNDSDLELEDLKNIVEDIVSENLLEID
                     TSDLEETKVIYKKNDVINKRLIIRFISPALISCKNENENGNIESGLEKTFYFATLFLD
                     LSLKQIIVSIPHTVGIKSIDNIEAKARDFSEIAKYYVSKLEDLLTTYNIQIEKYNDWI
                     YDATYELAEEGSAHNNPEINKKYEENIDKIDEFAKKIAIASGITDKAIIENFKEGVGI
                     LYENILIDEFGVVEDENQYSTFVQNGDGVNSYCRVGSKTATLKSGKGHAIAKTSRNNE
                     DVKNLGVMKSFNGTLSRFLIEVLDKELYLIRTDTSKFIEERVIYDVIRKVGEYKYTFR
                     KSE"
     gene            28312..28698
                     /locus_tag="KR257_002336"
     CDS             28312..28698
                     /locus_tag="KR257_002336"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0031019.1"
                     /translation="MMLYEKLENISILLGNQSKAKSIIEELEKLMKSDIITPRLLARK
                     TKVTLLEATRVLEFLVKENELEFFIVVECSNPDSVYENEIGHYKYFTSIKEFNAFSKG
                     QECPICGCGYKYNFEDTKIGFRRLEK"
     gene            28703..29473
                     /locus_tag="KR257_002337"
     CDS             28703..29473
                     /locus_tag="KR257_002337"
                     /inference="COORDINATES: protein motif:HMM:NF016362.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="restriction endonuclease"
                     /protein_id="HBH0031020.1"
                     /translation="MSLDTLKEYLSICDDNLIWEPFYDDSMLLDEFSNYIKEIELSKE
                     WNKSKNHEKGKILEQLVRFIMSRFTILSDISVNKSTTDNELDVFVKFNDNIPIPFLCN
                     IKSKIVCECKNWKSRKVDVGMVSKLAEICNKNNAGLGIFISLNGLTGKGWQYAEGKRR
                     KLYLSDKMPIISFTVDEITKLKYKRYNLLTMIKCKMQALIDEMEFAGGELRLLESELG
                     FIDCLNENIESLKMLGLITEVEYNNIKVRINHRYDIVN"
     gene            29531..30214
                     /locus_tag="KR257_002338"
     CDS             29531..30214
                     /locus_tag="KR257_002338"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861025.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="HBH0031021.1"
                     /translation="MQDVKEKVKQDYLKGMKQKEISAKYDISLNTLKSWIKRYNWANE
                     KKKGAPKNKRGAPIGNKNATGPPGNKNAEKFGFFSKYLPEETQDLINEIKDKDKFDIL
                     WEQITIQYAAIIRAQKIMYVKDKEEMIKELKKYESTENGEKIEYEFQFAWDRQASFLN
                     AQSRAMSELRSLIKQYDEMIHKDWNLATEEQKTRVEKLKCEVDNLSKDDIGDDELKIS
                     VDYGDRNDS"
BASE COUNT        12438 a         3185 c         5179 g         9442 t
ORIGIN      
        1 aaaaaaaaaa ttataaattt taaaaattat aaatgacatt ttaactagaa ttaattgtaa
       61 aaaacactat ataatactca attttcaaca ttctatacaa ttatacagaa attatacagc
      121 ataataatca ccgaaataac aaattttaaa aattaagcaa aactttttgt cgaagttcaa
      181 cgtctatata tatgtagtgt aaatttttgg gataaaatac tacaaaaata taaatgtaaa
      241 aatatagtaa tattggaggt cgaacgatga gaaataaaaa gaaaaaaata aatagaaaga
      301 agttgtattt gcttttaagt gctattgtag tgtgtctggc ttttatagta gttggtgttc
      361 gcgtcagctc tttaaatatg aaggaaaatg aaattagtag aaatgcaaaa ctgtcaagtt
      421 ctactattac agatatagta tctaatacat caatagaagt tagtaaaggg ccaagtaaaa
      481 gttctggaaa aatagcatac ataactatag atgatggtcc atctaaattt actgacgaga
      541 tgataaaaac tttaaataaa tacaatgtta aagcaacttt ttttatgata gatgggaata
      601 tgaaggaata tccacagcaa gttaaaaata taattaaaaa tgggaacaca gcaggttttc
      661 atagtgtatc acatgatatt cacaagcttt atgttactag tacatcagca aaagaggaat
      721 ttgatacaaa tgatcaaact ttttataaga taactggtaa acattcaaaa gtaataagaa
      781 taccttatgg aagcaaacca tatacaccac aagcctctta tcaggcttta gttgatgctg
      841 gatataaaat ttgggactgg gacttagata cagaagactg gagatctaat tcttctcaaa
      901 ttgtacaaaa tgtaaaaaat catattaaga atagaaaagg tgaagataaa gaccaacttg
      961 tagttttaat gcatgagaaa aaacagagtg cagaagcttt agattcagtt ttaaaattct
     1021 tatcagatga aggttatgaa tttgcgccag tagatcaaaa ccaaatacca aaaaattatt
     1081 ggttacgtaa tttagagtag ttaaaatata agaatattga ttgatatttt tagaaattga
     1141 gaataaaaat gagtgaggtg taggtatatt gaataaaaaa ctttatatag gaatggtcgg
     1201 aatattgtct ttgatgatgg ttggttgtaa taaaagttta gcaaaagtaa atgatgtgga
     1261 aatcacaaaa gaacagtaca aaaaaacaaa agcagtttta tctgctacta ataattatat
     1321 aaatgggcag tctttagatg aattagaaaa aactttggat aaaaaaggta gaaataaatt
     1381 agaaaatgtt ataatatcgt ttatggtgga taatgaactt ttatatcaag aggctaagga
     1441 taaaggacta actccaagta aaagtgaagt agactcaaaa tatcaagaac tagaagataa
     1501 gatgaatttg aatacaagct ataaggaaaa aatggacaaa gcaggtgttg ataaagatta
     1561 tttaaaacaa gaaatatcta gagatttagc aatagataaa aataaaaagg cctttgaaga
     1621 tagaataaac ataagtgata atgatatgga agcctactat acaagtcata aaaaagattt
     1681 taatgtagaa gaagtaagtg cttctcagat acttatatcg actttagata aaaataaaaa
     1741 agaagtaagc aaagataaaa aagaagcttt gaagaagaag gcagataata tattgactaa
     1801 aatcaaaaat ggagaaagtt ttgaaagttt ggctaaaaaa tattcggatg ataaagcaac
     1861 tggaaaaaat ggaggacagc taggatattt tacaaaggat gataaaaatg ctgagtttac
     1921 aaaggaagtg ttcaaattaa agaaaaatga agtttcaaat gtgtttgaaa ctagttatgg
     1981 atatcatata gtcaaagtta ctgataaaag agaaagacaa aaaagtttta atgagtgtca
     2041 gagtttaata agagaatcta ttttaaatga aaagtatatt gagcatataa aaaaactgaa
     2101 tgaagatgct aaaatagaca gatagaattt ctaacagctc aatcctagcc tgtaatcgga
     2161 gggagatttt acaggaatgt ttaagagttt aaagagaacg aaagttgaga aatacattat
     2221 cgataataaa gactcttttt atagaatagc atatagttat acgaagaatg aagaagatgc
     2281 cttagatgtg gttcaagaag ccatgtataa ggcactatac tcagtggaaa atattaaaga
     2341 agtaaattat ataaagacat ggttttataa aattttagtt agaacgagta tagattttat
     2401 tagaaaaaac cgtaaatata ataatatgac agatattgac cttatagatg agactggaga
     2461 gtatgataaa tatactgatt tggatttaag aagagctttg gaagaattac ctattgaata
     2521 caaatctatt ataatattaa gattttttga agatttaaag attgaagaag tagcaataat
     2581 attggatgaa aatgtgaata ctgttaaaac taggttatat actgctttaa aaaaactaaa
     2641 attaaaaatt gaagagtagg gataaaaaga atgacaagca aagaaaggtt aaataagtta
     2701 aaagatgagt atcataaaat tccaataccc aagaaattag atactataat aaatcatgaa
     2761 aaaatagaaa acatatatcg agagaaaaat aaaaaagtaa atagattaag atttaaagtt
     2821 gcaatagcct ttgcatgtat atttacagta ttagtaaata taagtcctgt atttgcagac
     2881 aatttttcta agatacctgt aattggagca atagtagaag taataactat aaaaaattat
     2941 agtttaaaaa gtgaaaatta tgaagctgag attgatattc ctaaaatacg aggtttaaaa
     3001 gataaaaact tagaacaaag attaaacagt agttttatgg aagatggaaa aaggctttat
     3061 catcaattcc aagagagaat ggagaagata caatcatcaa agaataaagg atataaatct
     3121 ttaagtttga gttatagtgt aaaaaataat tctaaaaaat ttctatcaat agagatgaca
     3181 aaaaatgaga tagaggcttc atcatatgtg agtaaggtac attatactat tgataaaaaa
     3241 agacaaatag ttttgacttt gccaatgctt tttaaagatg ataagtatat aaaagttata
     3301 agtgataata taaaagaaca aatgagagaa caaatgaaaa aggatagtac aaaatcctat
     3361 tttatagatc aaaaaaaaga cttgcctgtt gaagatttta aaacaattaa taagtatcag
     3421 gatttttatt ttaataaaaa tgaagacctt gtaatttgtt ttgatgaata tgaagtagca
     3481 cctggttata tgggcgcagt tgagtttgta ataccatata aagtaataaa agatttgtaa
     3541 attgaatagt agtttatata taaatctttt aaggaggaca atatgactac atataaaaaa
     3601 cttaaaaaat ctatatttaa aattgctata ttttcaatat gcttattagt ttcattagta
     3661 gatacaaacc ctatatttgc aggtagttcc tttaatgaaa cttcaaatag tgatacgata
     3721 aaggtgttaa atgctaagag tatcaacttt aaacaagaca attatgaagt gaatgtgagt
     3781 attcctaaaa taaaaggttt aaaagataaa actttagaga ataaattaaa caatgagttt
     3841 ttgcaagatg ggaaaaaaat ttacagtgaa tttcaaaata aaatgaaaaa ggaaaataat
     3901 aagggtcata gatacctaaa tgtaatccat aatgtcaaaa ataattctaa ggacttttta
     3961 tcaatagaaa tgacaaaaga agagatagaa gcttcctcat ctataactaa gaagcattac
     4021 actgttgata aaaatagagg aatactatta aatttaccaa tattttttaa agatagtaga
     4081 tatattagag ctataagtga taatataaaa gagcagatga gaaatcaaat taagaaagat
     4141 gatacaaaat cttattttat agaccaagat aaagactcgc cagtgaaaga ttttgaatct
     4201 ataaataagt atcaagattt ttattttaat aaaaatggaa atcttgtgat tagttttgat
     4261 gaatatgaag tagctcctgg ttatatggga gcagtagaat ttgtgatacc aaataaagta
     4321 ataaaaagac taagatagat atatagaaga tttttagata gactggtaag gagaattata
     4381 tgaatatata tgaacaagca ataagattaa tagaaaataa tgaggatttc gcatttgcta
     4441 caataacgtc tcattcaggt tcaacaccac gtgaaactgg agcaatgatg attgtgaaaa
     4501 atgattctac tatatttggc tcagtaggag gaggtagtgt agaagcagaa tgtataaaac
     4561 atgcaattaa tgttataaaa aacagagaat caatgttgta taaatttact ctaaacaaat
     4621 ctgatgtggc aaaactagga atgatatgtg gaggtactgg agaaatacaa atagatttta
     4681 tagatagtaa attaaaaagt aatatagaaa aatttaataa gagactaaag gaaaatacaa
     4741 gtaaagcata tatatttggt gcaggtcata tttcaagaga tgttgctgtg atactatctc
     4801 ttttagaatt tagaacagta gtaatagatg atagagaaga atttgctaat catgaaaggt
     4861 ttccagaatc agaagtagta gttttagatt cttttgaaaa cataccagat tttcccactg
     4921 acgaaaatag ttatataatt attttaacaa gaggtcatct atatgattca agtgctttag
     4981 aatgggctct taaaagagag gctggttata taggtatgat tggaagtaga acaaaaattg
     5041 gattgactta tgaaaaactc atgaaaaaag gttttaagaa ggaagaatta tcaaaagtac
     5101 atgcaccaat aggcataaaa ttgaatgctc aaacaccagc tgaaatagct gtatgtatag
     5161 ctgctgaact tataaattgt agagctaata aggaaaaata aactaatgaa cacagggagt
     5221 aaagatattg atactttaaa ggttaatttt agagggattg aaataaaagc agttttagta
     5281 tataaaaata gaaaaaatat ttctataaaa atagatccat ttggcaaaat aactgtaatg
     5341 agtcctccta aaatatccaa aaaaataata aaagatataa ttattgaaaa aggagactgg
     5401 atacttaaaa agtcagaaaa atgtaaagga agagaggaag tatataaaca aagaatgttt
     5461 ataactggcg aaaaatttct ttatttaggt gaagagtacc atctagttat aaaagaactg
     5521 ttgagagatt ctgtcaaaaa aagtaactgt agaataacta ttaacgaata tcaaatagtt
     5581 gttcagacaa atgatacaag tacagatttt attaaaaaat ctttaaaatc ttggtataag
     5641 atggaaagtg aaagaatagt attagagaga atagattttc ttaaattaaa ttgtgaaata
     5701 atgaagcaat tagttccagc gagtgttaag gtaaaagaac aaaataagag atggggaagt
     5761 tgtacagctc aaaaaaatat ttatataaac tcaaaaatat ctatggcaag attagatgta
     5821 attgattatg taataataca tgagtttagc catttagcac atatgaatca ctctaaaaaa
     5881 ttctatgatt tagtaaaatc cattatgccc gattataaag ataaagaaaa ttggctaaaa
     5941 ataaatggat ataaaataat aatctgaaaa cgattattcc aaaatatagg cgtaaagtat
     6001 aaaagaagta ttattgtgaa aaaaataaat aatctgaaaa ttttaaaaaa agtcattgac
     6061 attgtaaatg atagagaata taatctatat taacaacaaa acagaattga aatataaaat
     6121 taaaaaatta aaagcaatga cagagacaac aatactaata gtgttatcca cagagaacca
     6181 atgttgctga gaattggtgt taacagtagt ataatgatca ctctggagct tttgtactga
     6241 atatttttag taagtacaaa cgtatgtcaa cgttacatga ctaaggttaa ggtaattaat
     6301 tacccgacct gaaaaaagag gggtagatgt attttttata tctacaaata aggtggtacc
     6361 gcggaatata actttcgtcc ttataagtaa tatttatatt gcttataaag atgaaagttt
     6421 ttttatttta agtgatataa ataaatttaa tccatataaa attaataaaa aaataataaa
     6481 aataaggagg gatttttatg gaaaatactg tatatgctaa attaaaccaa ggaatagatt
     6541 cttttttaag agtggctatg actctaagaa gaagagaggt tgatatacaa tcaataagta
     6601 tgactgtaga taatatgaat aattcaggta taaaattaat agtaaatgaa gaaaagacat
     6661 ccttagattc tgtcttaaac catatgaaaa aactacatga tataagagag ataactgttg
     6721 aaagaatgag acattaatta aatatatttt ataaaactaa agataaatat gcttatttta
     6781 aaataaaaaa ctaaagataa atattaaata agaaaaatct tagattaaaa tataagtgtc
     6841 attgaattta ttagtttatc acagttaata aatttattag tttgttgtag ctaataaaaa
     6901 ctgaaaattc taaaattata attgtaagat tatataaatt tagaatttaa atctgttgaa
     6961 taatattaaa acaatgataa tgagtatgaa tttctaataa aaataaatat cataaaaata
     7021 agaaaaagta ttgggaggaa atgaaaatgg caagaatgta ttatgaaaaa gatgtggatt
     7081 tagaggtttt aaaaaataaa aaggttgcag ttttaggtta tggaagtcaa ggacatgcac
     7141 atgcacaaaa tcttagagat aacggtgtac atgtagtgat aggtctttat gacggaagta
     7201 aatcagcaca aaaagcaaaa gaagatggat ttgaagttaa gagtgtagca gaagctacaa
     7261 aagaaagtga tttgacaatg atgttaatgc ctgatgaaaa gcaaaagaaa gtttatgaag
     7321 agagtgtaaa ggataactta aaagaaggtc agacattagc ttttgctcat ggattcaata
     7381 tacattataa tcaagtacaa ccaccagaat ttgttgatgt tgtaatggta gctcctaaag
     7441 gacctggtca cttagttaga aatgtattta caaagggaag tggagttcct gcactatttg
     7501 cagtatatca agactacact aaaaaagcta cagagacagt tttagcatat gcaaaaggga
     7561 taggagcaac aagagcaggt gttttagaaa ctacttttaa agaagaaaca gaaacagatt
     7621 tatttggaga acaatcagta ctttgtggtg gaataagtga acttataaaa ttgggatata
     7681 aaacgcttgt agatgcaggt tatcaaaaag aagtagcata ttttgaatgt ttacatgaaa
     7741 tgaaactaat agtcgacctt atatatgaag gtggatttga aagaatgaga tatagcataa
     7801 gtgacacagc agaatatgga gattatgtat ctggtaaaag ggtaataact gatgctgcaa
     7861 aacaaggtat gcaaaatgtt ttagaggata tacaaaatgg aaaatttgca aaagcgtgga
     7921 ttaaagaaaa tgaagaagga cgtgaaaact tcctaaaaac tagagaagaa gaatataata
     7981 cagaaattgc cgaagttggt agaaatctaa gaagtatgat gtcattctta aaataaatat
     8041 atattaaatg gattagtttg agggaaagag tggtgtatag tagtgcgtat gagtggagca
     8101 aaggtaattt tagaatgttt aaagaaagag ggaattgaca caatatttgg atatcctggt
     8161 ggagccgtga tacctcttta tgatgctcta tacgattatt cagatgattt taaacatata
     8221 aggacatccc atgaacaagg tttagttcat gctgcagatg ggtacgcaag aagtactaat
     8281 acagtaggag tttgttttac aacatctggt ccaggagcaa caaatgccat aactggaata
     8341 gcaacagctt ttatggattc ttcacctatg gttgtaattt cagggcaggt gccaactagt
     8401 ttattaggaa aagattcttt tcaagaaatt gacataactg gagcaacatt atctatgaca
     8461 aaacataatt atttagttag aaacactaaa gaattagttc ctacaataaa agaagctttt
     8521 agagttgcaa attcaggtag aaaaggacct gtacttgtag atgttccaaa agatttattt
     8581 ttagcagaaa tggattttag tggtgaggac tatgatttat gtcaaataga tgattatatg
     8641 gattataaga gtgattttga tctagatgat gaaactaata ttaagctttt aaatgaagca
     8701 atagatatca taaaagaatc taaaaagcct ataatatatg caggtggagg tgttaaatct
     8761 tcagacagtg aggaaattct tgaaaaattt gcaactaaga tagatacacc cgtactaaat
     8821 acacttatgg ggcttggaaa tatagataga aagaatgaat tatctcttgg aatggttgga
     8881 atgcatggaa gtagagaaag taatttagca ctttctaatt cagatttagt aatagcgata
     8941 ggtgcgagat ttagtgatag agtgataagt aaaagttctg aatttgctaa aaatgcaaaa
     9001 ataatacaca tagacataga cccatctgaa ataagtaaaa atatagaatc taatgtatct
     9061 ttggttggag atgtaaagct agtccttagt ttattaattg aaagggttga aagtaagaat
     9121 aatagcaatt ggaaagaaga gataaagaga tttagaaaga gtgagggtgt acaaacatat
     9181 gaatttcatc cacaaaatat actaaaaaaa ataaatgaaa aatatgaaac attaaagaaa
     9241 cccactgtgg tagtaactga tgtcggtcaa catcaaatgt gggctgctaa gtactggaat
     9301 tttaaaggta ataaaagttt tataacatca gcagggttag gaactatggg atttggttta
     9361 ggtgcagcta ttggaactaa agttggtaat gtagataaaa atgtagtttt agtcactggt
     9421 gatggaagtt ttagaatgaa ctgtaatgaa ctagctacag ttgcaaatta taatgtacct
     9481 atgcttattt tattactcaa taatagaaca ttaggaatgg taaggcaatg gcaaaagtta
     9541 ttttccaatc aaagatactc tcaaactgac attaatgaaa atgtggatta tgttaaactc
     9601 gtaaatgcat ataatattga tggatataag gtatccagta tggaagaatt aggaaaggcg
     9661 ctagatatga tagattttaa taaacctgta tttttgcaat gtgatataga taaggattat
     9721 gatgtttatc ctattgtagc acctaatgat gcattggaaa atttgatatg taactaaaac
     9781 ttatactgaa tattgataaa attttttatt aaatttttat tggtattcag tttttgttgt
     9841 ttagagatag attggcattt tttatttttg caaataaatc aatgactata taattaagaa
     9901 cttattaaat tttaattata caatttagaa tagtattaca acttaagtaa atattaagtt
     9961 ttatttgtta gatttattat taatacctta tattagttat ggttgttata tactctaaag
    10021 ccttgaaatt acaagtatat agatgattat ataaatttga taattttagc ttttaaaata
    10081 gataaattag attttgccac ccatttgcca ccgtattata tttttgggtg gcaaactcta
    10141 atttgtaatt ttttcaaata tatctacagt ttcatttttc attttatcag ttacatgtga
    10201 ataggtatcc attgtagttg atagttggct atggcccaaa cggttttgta tgtctttaat
    10261 gttagcacca ttttctaata atagagtagc atgtgcatgt cttaaagaat gaaaatggaa
    10321 gtcattgttt aaagctactc gaatttgtct tactatagtg tctaaagtgt gagtattcac
    10381 ttgttgacca ttttctttgg tacataccca gtcactatca aagtaaaatt ctccatattt
    10441 taatttcatt ttcttttgat ataatttatg ttcttttaat gcctttatta aagtgtcacc
    10501 tgtaaatata gttctgcaag agctttctgt ttttggttgc cctaattcaa acattccatt
    10561 tggtttttta atcaaagtat gtcttactgt gatagtttta ttatcaaggt ctatattatc
    10621 ccattttagt gcaataattt cacctcttcg cataccagta tgaaatccaa ttagtaaaac
    10681 tatacgttga aatgaatctt gaggaaatat atttagtatt tgattaaatt cttctaatgt
    10741 aatagtttta attttattag tttctgtttt agatttagtt tttggtatgc tcacatattg
    10801 catagggttt tctcgtatat gtttgtaagg atggactgct gattttaatg acctatgtaa
    10861 tatggctttt aatacttgta atgtattttg agagtaatcc tctttgtact ttctgtttat
    10921 gaagttttgt agtattgcag gagttaaagc ttttactttg taagctccta gttttggctt
    10981 tatatgtttt tctatgttta ttcggtagct ttcttgagtg ttgtatttac agttaagtaa
    11041 gacatattct ttgtaccaaa agtctaagta gtctgataaa ctgatattgc tttcttcaaa
    11101 tactatgcca gagttttcat attcatttag tgcttctctt aaggcttttt ctgcttcttt
    11161 tttagtattg cctccaactc tttctacttt ttttcttttt ccttctacta tgcctaggtc
    11221 aaagtagtaa taccatttgt tacttctttt tcttactcca cctttcataa tagtatccct
    11281 cccttttaga atgtatgttt gtttggtgtt tatataaaag agcagattaa ctgctcttta
    11341 tatacttttg ttatgtacaa tattatctta attttgttta tttggttttt acttaattat
    11401 tttcttaata ttcttacaat tttttagctt ttatgtgtag tttattataa taatattgaa
    11461 atatatattt attaagtaaa aaatctataa aagtagaata aatgagttta aaaaatatcc
    11521 tcatatatgt agaaatttgg caaattagtt aatactaaaa atctattatt tcctaagtcc
    11581 aacatgcttt tcttttttga tagaaattct aatcttttta gtaagaagtt gatgctaact
    11641 tgtaattctt cagctatttc gtatacactt gtagcgtgtg aattaataac atgtattatt
    11701 tcttcttctg ttataagaaa ttcacatgcc cattttagtg ctttgttttc agttttgtct
    11761 atcaagattt tatttttgta actgtttttt gaagatacat agtttccaac actggtaaaa
    11821 tgatgtccta attcttctgc taagatttct attagtttag cattgttttg ttttaatgaa
    11881 ttaagtaatg atataatttt tagtccttgt ctgtttatat acaatccttt tatgtcatct
    11941 gctattttgt cagtgtagta aatttctatc tcttcattat ttgctaagtc taaaagtgcg
    12001 tctagtttgt tcattgaaat ccccctataa aaagaatgta tttttgattt ttgttatata
    12061 taaagagcag gtgtgaactg ctctaaatat tcatttttta tccaaaaaag attggataat
    12121 tttagctgta gacaaaatat ggattatagt atatgattat aatataatta catataatat
    12181 atgtaagcac ttacaaatgt gtgttagtat agttagcact aaatttgtat ttgtgcttaa
    12241 agcgattaaa ggagttttgg agcggtgggt agagttttac tcactataac caagactctt
    12301 ttgcatatta gagtatttca tgtagtcata tattctaata agccttctta aatttgtttt
    12361 ttcgcttgtt tttgcagact ctaaaatatt aggattttcc tcaaatattt tcttaagtag
    12421 attttctaac tgttcagtgt caatttcttt ttcttctaaa aaagcaataa gtcttgtagc
    12481 tttttcaaat gattgatgtt catcattcca aataccataa acacttctat tttttatgta
    12541 agtattattt ctattttttt taatactatt gctaataata ttttcaaagt cactttctag
    12601 tgcaattgtc ctataatctg gaaattcaag tgtgctatta aaaagatgtt tatttaatgg
    12661 taatttatta tattgcttaa ttaaagatgg ataagcatat tcaagtaatt catctgatga
    12721 aaattctaag tcattcatga ctatatcacg ataccattca tcaaaactta atccttttaa
    12781 tcctttaaga ccaaaatcac ttgccttgcc aactgctaaa actaaatctt catcttttat
    12841 tcttgtatca tcaacactac caacccgaat tttagcagta ggtttgttag taattgtgaa
    12901 atcgtaaaat tcttgtttga acattcttaa tattctaact ggtaattttg attttttttc
    12961 agataatgcc tcatagagta aattaaaatc ctccagttta attttagtca tagtaatcat
    13021 tttattatca aaaacaattg tatgacttga tatttctata tcattaaagt ttttttcata
    13081 ctcaatgaat atgaaacgtt cctcgagttt tttagcattt tcattagata gacaattaac
    13141 tatagcatta agtatttttt ttatatttac atctgtaaca gagtaaccaa taaatatgat
    13201 aggaaactca acaaatatag tcattagctt agctgccaag taggcacttt tgctgtcaaa
    13261 gtctatataa tcagcttcat ttattacaat actatttgga gaagaaacac atccatgaat
    13321 tttataaatt tctgcaatac cttgtataga tgaaaaaact aaattttctt gacctatata
    13381 tgttgtataa ttatcaacga tagtttccaa aaaacaatca taatttgttg taataaatcc
    13441 tgataaactt tttttagaga tattactaag tttttcaact tcatcttgat atttatctac
    13501 tattttagaa ttatttttaa tatacatagc aatttctgcc ttaaatggag aaactcctga
    13561 tttaacaata tctaaatact tagagtctaa gcttcgtata gaagaatctg aaaaccattt
    13621 tttattaaaa tcattttcaa taagttctgc aattctagga tttataccca tttttgggtt
    13681 ctctgatttt gctttatttt tataacttgt atatataaag tcatcattac taattttttc
    13741 tgcaaagact tttagtaaat cctcccaatt tggaagatta tagtatcttc tagttaaacc
    13801 agaaccaaca aataaaaatg gtgtagcatt aaatcggttt atgacatctg atattataga
    13861 tttcatataa tttatcacct acttttaatt tattttttat acttatttat taaaaattca
    13921 atataatcat tgagttgttc ttgagcttcc tctggtaaat ctttgtgagg attaactcta
    13981 tgtgcagcta cagtgtctat atcatttttt acaatagacc tacctaataa ataatcagta
    14041 gtcacattaa atatttcagc aaggctagat agcatataag catcaggaac tgtctttcct
    14101 tgttcataat aaccataagc gcttttggtt aagtttaatt tatttgcaac atcttcttga
    14161 gtcatatttt tttcagctct aagttctttt agtctttttt gaaataatgt attattacaa
    14221 gaagttttgc tagaaatatt gcttgcttta ttatcatacc tacctattaa ataatcaaca
    14281 gtagtgccaa aatattcagc taaactagat aacatttctg gggtaggtgt tcttttacct
    14341 tgttcataaa atccatatgc actagtagtt atgttaagat agttggcaat ttctttttgc
    14401 attacacctt tttctttcct aagaaatttc aatctatctg ataaaatgct catataatca
    14461 ctcctcttaa taaagttgcc tttattaaat aatacaacaa atagttgtaa aatgaaataa
    14521 aaaaataaaa aaactattta caaacaacat atagttgtgt attatataag tataaacaac
    14581 aaaatgttgg taaggaggat atagcttgaa caatctaaag gaacttagga cagaaaggaa
    14641 tttaaagcaa aaagatgttg cattaaaagt aggtataact actagttatt atggaatgat
    14701 tgaaagtgga acaagagtac caagtttagc aatagcaata aaattatcta aatgttttgg
    14761 agtatcaata gaaaaaattt ttttaaatac aaatacaaca agatgttgtt taaaagagag
    14821 gagttaaata tgaaagattt aaaaatagta aaagttaata ataaactaac aactgacagt
    14881 agagatatag ctctaatggt tgaaaaagaa cacaagattt tactaaggga tataagaaat
    14941 tatataaacc aaatggaaga agccaataaa aacatgagta cagatttgta cccatctgat
    15001 tattttattg aaaatactta tttagatgat tataaaagag agaagccatg ctatgcaata
    15061 acaaagatag gttgtgactt catagcaaat aaaatgacag gcataaaagg tacggcattt
    15121 acaggaatat atacaaaaaa atttgaagaa atggagcaag tattaaaaaa tgaacaacct
    15181 aaactaccaa ctacatataa agaagcatta caacatctta tagagcaagt agaagtaaat
    15241 gagaaattac aactagaagg aaaaatgaaa gaccaagtaa taaaagaact aaaaccaaag
    15301 gcagattata cagatatgat acttaaaaac aaaggacttg tcacaataac tcaaatagca
    15361 aaagactatg gaatgagtgg aaaagaaatg aataaaatac ttcatgaaag agggattcaa
    15421 tataaacaaa gtggacaatg gcttttatat aaacaacacc aagggaaggg atacactcat
    15481 tcagaaacaa tagacataac tagaagtgat ggaatgactg atgtaaaaat gacaactaag
    15541 tggactcaaa agggaagatt gtttttatat gacttattaa aagtaaataa catattacca
    15601 gatatagaaa aagagtatag ttatcaaact tcaatgttat gttagtactt tgaaaaataa
    15661 atacagaata ttcaaaaaga ggtgatttaa aggttgagta atagaaagaa gtataccttg
    15721 agtattacga aagaattata caataaatgt aaagaaaaag ctaatcaaag aggtatgtca
    15781 gtgaatgatt acatactatc agtgattagc aagagtatat aaattattct tcaatattaa
    15841 ttttaatttc tccttttctt tgctcataat cttcaatatg tttttttatt atttgttcaa
    15901 tttccttatt agcagaacga ccttcgcttt cagctatata tttaattttt tcaagcagaa
    15961 ctctgtttat tcttaaagtg tatttaggta gtgaagttga cataataata cctccttttt
    16021 aaagtctaaa tgatgtcata attatatcat aaaaataatt tatagaaaat ctataaaata
    16081 tattgacggc ataaagacgg cgtgatatta ttaaaacaag aaaggggttg acggcaaaat
    16141 gaactcaaat aaaaagagaa taactgttag gatgccagaa aaattaaatg aagaaataac
    16201 gaaaaaatca aaatacttag ggttaactaa gaactcattt atattagata tactatggaa
    16261 ggaatttgag ttattagaat atagaagtta taaaaaggag gtagataaac atgaataact
    16321 tacaagtaat agaaagaaat aatgagagag ttctaactac acaacaatta gcagatgtat
    16381 atgaaactga ctcaagaaat ataagtaaca atttcaacaa taacaaagat aagtttattg
    16441 aaggtaaaca ttatttttta ttgcaaggtg atgatttaaa gaattttaaa ggcattcata
    16501 cagaatatga aaacctaaaa tttgcttcaa aaatgtatct ttggactgaa agaggagcaa
    16561 atagacactg caaaatatta gatacagata aggcttggga acagtttgat aatttagagg
    16621 aaacatattt caaagttaag caacataagc caacttgtat agaagatgta ttaatagaaa
    16681 gtttaaaaga aatgaaagat ttaagacttc aagttaatca agcaaatagc attgctttag
    16741 aagcaaagac agaggttgaa acaataaaag atgtagtttc attagactca aatagttgga
    16801 gaacaaatac acatcaacta attgcaagaa tagcaaaaaa acaaggtggt tttgaacata
    16861 taaatatgct tagaacagaa agttatgaat tattaaataa gagatttgga gttgacctac
    16921 atagaagatt gatcaataaa agaagaaaaa tggcagaaga aggtgtatct gaatctaaaa
    16981 gagagaaagt taacaattta gatgtaatac aagatgataa gaaactcata gaagggtatg
    17041 ttgctattgt aaaagatatg gctttaaaat atggaatatc aagtgattta agcaaaaatt
    17101 aagttaaatc acaacagcac tttgaaaact aaatataaaa taaaaatatc tcccttaaaa
    17161 gttttttaaa gagagataaa cactttattt tgtaactatt tgaatacatg atggatgaat
    17221 gcaatagttt ttatctttgt aatttataga aacataatta ctagagtaca ttttatcaag
    17281 gttttcatta atatattcaa ttgcattaca gccatttata gagccaatat cagttatatc
    17341 aatccagtta ttaaatatct taacataaac aaacttcatg ataacaccaa ctttcattag
    17401 aatttaagtt aattataaca tggtgtactg agataatgtg ttaagaaata gatacagaat
    17461 attcaaaaga ggtgattaga tggaaataga gcaaacaaca atacgcctgc taaaaagcag
    17521 acgaaagttg aatattaatt tctattttgg ttaggcgaaa gacctaacaa aaaatctgta
    17581 gatacattaa gtttgttaga aattaatatt aaagtttcta gatttggttc tcttgaacca
    17641 gcttcataat actgatatgc acgttctgag ataccaaaca aactagcaaa ttgcttttga
    17701 gtcatattca tttgctttct tactagctta atattatctt tgaatttagt cataactaca
    17761 cgctccaata aaaaaataaa taaatttctt gacacgaaca atattagcgt gtaatatata
    17821 aaacatagca cgaacaatat tggcgtgtta aataaaaagg agagggtgaa aataaataat
    17881 aatttaaaac tacaacgtga aaaaattggc ttaacacaat tagaggttgc tcaaaaagcc
    17941 aaaataacag agagaagcta tcaatattat gaagctggcg aacgtctccc aaacattcgt
    18001 acagctttaa agatagctat aattttaaat actaattgtg aaaaactctt taatgaataa
    18061 tagcataaaa ggactcagat tacaagaaag gagctttaga tatgaataat ttgcaactta
    18121 acaataaaaa tacaataaca acattagaaa ttgctgatat gttagaaatc agacactggg
    18181 aagtcttaag gaaattagaa ggaacagaaa aaacaaaagg aattattgat attcttaacg
    18241 acaacaattt tgttgtggtt gattacttta taaaatcaac atatttggat tcaaaaaatg
    18301 aaagtagacc ttgctataat gtaacaaaat taggttgtga ctttctagca aataaattta
    18361 ctggagaaaa aggtattatt tttacagcta gatatgtaag aagatttaat gaaatggaac
    18421 gagtattaaa agaacaacaa cctaaactac caactacata taaagaagca ttgcaacagt
    18481 tattagtaga agttgaagaa aaagaacaat tacaattaga aaatcaagaa aaagataagg
    18541 taattcagtt acagcaacca aaagtactgt ttgctgatgc agtttcagct tcaaacaatt
    18601 ctatattagt tggagaactt gcaaaactta taaaacaaaa tggagtagat ataggacaaa
    18661 acagattatt tacctggatg cgagaaaatg gatatttaat taagcgtaaa ggtgaagatt
    18721 ataatattcc aacacagaaa agtatgaatc taagaataat ggaagttaaa aaaagagtaa
    18781 ttaataatcc tgatggaagt actaaagtaa ctagaacagt aaaaataact ggaaaaggtc
    18841 aagtttattt tgttaataag tttaaaagta gtaaacaatt atcaatgtta agttaaatca
    18901 taacagtacc ttgaaaacta aatacagaat attttggaaa ggagagattg aattggaaaa
    18961 taagaaaata gaagaaatag agaaaagaat aaccatgctt gaaaatcaat tgcaagcaca
    19021 gttatttagt cagataacag ctcaatcaaa tagtgatttt atagattata tgtaccaatg
    19081 tatagttttg tatttacatg agatgaataa aagtgaaaaa agaaaaatta gtgaaattac
    19141 taaagaaaga atcagaaaat aagaatgata attacaatat aaaacctatt cttctagcag
    19201 gttttgaagg gtcagttttc tttactgaag ttatcataaa gtttatctgt gatgtgtgtt
    19261 gaagaatttc agaataaact ccatttacta tgccgtagta gtgaattaga caagggttat
    19321 gataacctac ttcttcaaca atcattaata catcttttcc aaagttagtc aattttagtg
    19381 caatttcatg ttcatcatca agttcttttt caaattcctc tatagattta agaataattt
    19441 tatattgaaa ttcagcatag taaaaatact ctgtgttaga agtatcagag actgtctttc
    19501 ttatactttc ttgtaattct ttagatatat tgtttgaaaa ctgcataata caccatcctt
    19561 ttgaaaattt tggaatttat tccatgttta tattatacca tgtagaactg aggtgaatac
    19621 aatgttaata ggcgacaata taaagcaaat actaagaaaa agagatataa aaccttataa
    19681 attagcaaag gaattaaata tagatgtaag tggtctatat aaattgttga agaataaaaa
    19741 ttctaatcca actatagata ctctaataaa attagctgat tatttagata ttacattaga
    19801 cgaattagtt ggaagataaa tatttgaaaa gaggggagag aattttaaca tggatatttc
    19861 tgaaagtata acaaagcaat ttagtgatag tttaaaaagt ttaatagaaa tagagataaa
    19921 taaacaagaa acagatagag ttaagagtca aactgttgaa caaaaggtaa aagtactgga
    19981 gcctaaagat atagttgttt taataaaaag aggttatcca aattatttga taacagtaga
    20041 agaagcaagg ggaattttaa aattagatac agtttttatg cgtaggttag tgagcacagg
    20101 tttgataaaa tcactggcta gaggtgatgg tagaaaaatt tcaagatatg aagttgatga
    20161 ttttattgaa agaaatcaag gtaaaaattt ggatgaactt ttaaaagtag cagagagggg
    20221 ggatgaaatt gttaagcctt aatactaata agaataatat agtaactctt aaaaaagatg
    20281 gaaaagctat agcagacata gtatttaaag atattaaaac tggtaagaaa atatcggttg
    20341 gagtattaaa taaaaaagtg ctggtcaaat aaccaacaca caaaaaaata aaaaataaaa
    20401 tataacacaa acaaattata gcacaaaaag aatggattta gaataggtaa tataacattc
    20461 taaaaggttt aatgtgtaat aattgtaaca atttagaatg tagcttatat agatagtaat
    20521 aaattgggag ggatttaaat ggaagcagct agactaatag caataggtca aattaaacaa
    20581 gcagaaaaag aaatatgtaa attacaaggt acaaaaaata atagtagttt aatgtggtgg
    20641 gaagccgtaa aatttgctag tcaaaatata ttagagggtc ttgaacatga cattgagtta
    20701 gaagcttcta ttgagtttag agaagctatg atgtatcaag aagaacttga aaaagataga
    20761 ccaatagatg tccagatata aaaaaagagc cttcgcacag gctctaagtg aaaataagtt
    20821 acaaaaatta taggtatatt ataacataag ggggaataaa tgaaaacaaa aaatgaaata
    20881 attaagggtt tagaagatag attattttta ttaagattta caacagtaga tgaagtagat
    20941 tgggatgtaa aatttggaca aatatcagca ttagaatttt gtatagataa acatagaaaa
    21001 ggatgcactt tggaacaatt caaagaacat ttagacgaat acaaattaca agggaactat
    21061 ggtgattata tagatggttt tgtgtcagtt ttagaaagaa atattagaga aatggaggga
    21121 gaaattgatg gaagtgaata atatttacat aaaattgatg gatgtaagaa ttaagtttaa
    21181 caaattagat ataaaaaaga gtggtcaaaa caagtttgct aactttaaat attttgagtt
    21241 agcagacttc ttacctcaag caacagagct gttacaagaa gctaaattat gccctatagt
    21301 gacctttaca aatgattatg caactctaac attgattaat ggagagaaac caacagaaga
    21361 gataatattt acttctccaa tgagagaatt acaattaaaa ggctctaatg agttacaagc
    21421 attaggagga attgaaacat atcagacaag gtatttgtac attcagttat taaacattac
    21481 agaaaatgat acttttgatg ctactagtgg aaaagaagat tataaaagaa atgacttaac
    21541 aaactcctct attaaagcaa gtgaaaatgg tcaaataaaa ataagtcaaa atcaaataaa
    21601 aagattgttt tcaataggaa atacaatagg caaagattca gatagagtaa aaagtgaagt
    21661 gtattataag tttaataaag aagttaaaga tttaagtaaa caggaatatg accagatatg
    21721 tgttggatat gagaaattac aaagggaaaa aggaataatt aagtaggtga atttcttgaa
    21781 ggacagagac aaagcaacta tagagaaagg aaatatactt agtgatgggt atggtctttc
    21841 accacaattg gtagctagag attcatggct aacaacagga gcaagagctt tatatttcta
    21901 tctatccagt tttgcaggag caagtgggac atgttatcca tctagggata ttatgactca
    21961 tgaacttggt ataaataaag atacttttag taaataccta aatgaactaa agacgagtgg
    22021 ttatataaaa gtatataaaa ataaaactag ggaaggaagg atgcaaaata atatatatga
    22081 ggtagtattt gatagaagct atatagaaag tcatatatcc attagatgta agaaagaaaa
    22141 taaaaaaaac catgtccgaa aaaagcagac atggaaccat gtccgaattt accggacatg
    22201 gttcaaccgg acatggaaaa gtcggacact ataagtaaca gtattataaa taacagtttt
    22261 aaaagtagta tgtatataga gcaagctgtg gataactctt taaaagaatt taagaagcta
    22321 tatgaagaaa atataggagt agtatatcca gtcacagctg aatggttatt agaagtatct
    22381 aatgaagtag atataagagt atttaaaaga gctatagaga tatgtgctga aagaatgaat
    22441 atgaatttat catacttaaa aggaatcctt aaaaagtgga aggatgcaaa tataactaca
    22501 tatgaacagt tagaatcata taaattacaa catgaaaata aaaagtcaaa aaaaaccaat
    22561 agtgtagtaa gcaaaaataa gtttgctaat tttgaacaaa catttactca atacagtaac
    22621 aaagaattag atgaaattat aaagaaaagc caaaaggcta aatttaaata atattgatgg
    22681 aggtattaaa atgaatcaag ttgtattagt tggaagatta actagagacc cagaactcaa
    22741 atacatacca ggaacaggta cagcagtagc atcatttaca atagctgtag acagaaatta
    22801 tataaataaa gaaggaaaaa gggatactga ttttatacca atagaagtaa taggtaaatc
    22861 agctgaatac tgtgcaaatt acataacaaa agggaagcta gtagcattag aagggaatat
    22921 aagagttgac aattatcaaa ctcaatcagg tgaaaaaaga atatttacaa aagtcagtac
    22981 aaaatcagta caatcattag aaagcaagaa taaatcgagt aattcatata aagagagtgt
    23041 acaagatgga accataggac tagaccctca aggatttgaa attatagatg atgatgagtt
    23101 accattttaa tctgaaaaat taaatatgag gtgaaataaa tgtttaaagt agaaaggtat
    23161 tttagtggct cagtagtgga caaccttatt gaagatgacc ttacatgtag aaactactta
    23221 gcattatatt gttgtttgtt gggaattaca aaaaatggaa aaaagatata tcctaagcca
    23281 gaaaaaatgt tagctgagtt tggagtaaag aaggacagaa aaataaaaaa agagttacca
    23341 gtaagaatta gaaatgttaa tacaggggaa gtaaaagaat ttgagtctat agatggtgca
    23401 gcctgttttt taagattaaa atatcaagca gtttatcaag ctattaaaaa gaaaactaaa
    23461 acaagaagtg gctggaaagt tgaatacatt aaggaggaat aatggaagtt tcaaggacag
    23521 aatatacaat taaaagagca aaagagttat atgacaatgg agaggatata tttattgcta
    23581 tagataaggc tagagaaaaa tatgaggaga tgattaaaag tgaatatctt agctagtgtg
    23641 atattagtaa taggaagttt tatagctggt agagtttatg agtatagatt gaacctaaaa
    23701 gggtgtgaaa attgtgataa taagaaggtg caaatatgaa tgtattaagt ctattcgatg
    23761 gaattagttg tggtcaagtt gcttttgaga gagctagaat aaaagtagaa aattattttg
    23821 caagtgaaat aaaagagatt gcgattaaag tagcaatgaa taattaccca aaaacaatac
    23881 aacttggaga tgtaagagag ctaaatgtaa gtaaaatccc taaagtagat attcttattg
    23941 gcggaagccc atgccaaaat ttaagtaaag gaagattaat agctaataaa atacaggatg
    24001 gattaactgg agataaaagt aatttgtttt gggaatatat aagaattcta aaacaattga
    24061 atccagaata ttttctttta gaaaacgtag tgatgcccaa aaaagatgaa aacatgataa
    24121 gccaattgtt aggagttgaa ccaatcaaga taaatagcaa tttagttagt tatcaaaata
    24181 gagacagatt atattggaca aatattttaa atgttcaaca acctaaagat ttaaaaatta
    24241 gttttcaaga ttataaagat actagttttg attattgcaa agagtttgaa attaaaaaaa
    24301 ctccaagtag agaaaaaatg tggggtaatg gtttaaatgg aaattgtaag aatgtaacat
    24361 atgaagacaa aataaactgc gtaacattaa aacaagatag atttagtaat tcaggtttag
    24421 tagaatttgg gtctttctgc agatacttaa caactagaga attagagtta gcgcagacgc
    24481 taccagttgg atatacaaaa ggtttgagta taagacaagc acaaaatgtc ataggtgatg
    24541 gttggacaat agatgtgata gcacatattt tatcaaatat taactagttc tttatatata
    24601 aattattatt gaagcggtta gctatcatga tacttgtagc agtaagtttt atagctggta
    24661 gggtttatga gtatagattg aatctgaaag agtgtgaaaa ttgtaataac aactatcctg
    24721 aaaaatgaga aagaagtggt tttatgaata aaagaataat ttgcaattgg tgtggtaaat
    24781 tattttacat cccaaaacag tctaaaaaaa tttactgttg taaaagatgt gagagaaagg
    24841 ctaagaaaag caatagagaa cagcaaaatt aattttaaac aataaaacta tgggggaata
    24901 gcaatgaata agtttcaaaa agcagtttct caaatggtga agcaagagga aaaagaaaac
    24961 ttgttgcaag gatatgagaa ttgtatagta ggtagaagta tatcaagttc cataagaaga
    25021 tatgtaaaag ggtttgaaaa gtttggatat agtgtacatg aggtttatga atttataaac
    25081 gatattaata agtatgagta actttaagtg ataaaggaag tatttgattg agtaaataca
    25141 ataataagaa aattgtaata gatggaatta aatttgatag taaagatgag tcagagtatt
    25201 atttatattt aaaagaaaaa aaggaaaatg gagaaataaa agactttgga cttcaacaaa
    25261 agtttgaact acaacctaaa tttaaaaaag atgggaaaag ctatagagct attacatata
    25321 caattgattt tgccatatac aaatggaatg gtgaagtcgt ttatatagat gtgaaagggt
    25381 atagtacaca gcagggtgaa cttagaaaaa agctttttga ctataaatat caggacaaaa
    25441 aattgatatg gattgctaaa agcaaaaaat atggggtaga tggttggata gaatatagtg
    25501 aacttaagaa aaagagaaaa gaaaataaga aaaaggtagc ttaaataaat aggagtgatg
    25561 ttatggcaag taaagttaaa aaggagtttt ttatggcaac taaaaaacac cttgagaact
    25621 acaaacaact acatattaat attgaaagtc taaaacttca aataaaaaat ctcaaagagt
    25681 tccatttagg tgattttatg caaggtttaa gctatgacag cattcccata agtaagacta
    25741 attcaataag taatcaagtt gaaaatgagt taattaatct tgaagaaaag ataatagaaa
    25801 agcagataga attatatgaa atggaagcac taaaatatac aatagatgta tccataagta
    25861 atttaaaacc tatacataaa caaattataa ggtataggta tattgaaggc ttagaatgga
    25921 gtttaatagt tgataaagta tacttagaag aaagacaatt aagagaaaga gctaatcaag
    25981 ccattagttc aatatcaata gccttatttg gtaaaaaagc attaatagag caagaaccat
    26041 tatttaagat gttagattta taggcagtta ataactgtct attttttttg tgaaaaagat
    26101 atatggaagt tattgacaat atcacgcata cgtgatatta ttgaagtata gaaaggaggc
    26161 gaaaagaaag tggctaagaa aataaaagag ttcagaaaac tcataaaaga attaactgaa
    26221 ctcgtactcg aagttggcac actattagca gtcatcaaaa tggtaataga tagcctacat
    26281 tagtaaaatg ttaagagtgg aagttgcacc ttccctctta actaaattat aaaacatagt
    26341 cactaaaaat acaatgaata agtatagaga gttaacattt gaattattga aactactgta
    26401 tgacactatt aaattaattg gagcatcaat attgttatat tatgttatta actcaatttt
    26461 ctagcaatga ttaggaggta ttttatgaat cgatttgaag gtatttatag ctttgcagaa
    26521 gcaacaaaat tatgggattt gaaagattct acacttagaa aagcagttgc gacaggcaaa
    26581 ttagttgaaa atattgattg taaaaagttt ggtcgtgatt gggtagtaac tattgaagca
    26641 atggaaagag aatatggaaa attaaataat ataatgaaag acctagatta aattctaggt
    26701 ctttttattg ccgcttttct gccgatttta caatttaaaa tgtgagataa tagtattgtg
    26761 gaaatgaata tttctctctc aaaactaaat atatgtgggc taggttaagg gattcgccta
    26821 gcttatatga acaaactagg cagggcatga ggatgctgta agttcaattc ttactatgtt
    26881 caaacttatt aatacactat atgtagatat gctggattaa aacggaattt aattcaaatg
    26941 tctaaaagag tggggcttgg taacctcact caatttgcaa ggactggtgt gtaatcttag
    27001 gttcgattcc taaaacttgc tcccttaaat ataatatgta tccccaaaaa aaggcttaga
    27061 ttaaattcta agtctttttt taataattaa tgtagataat aatatttatt gctaaaatga
    27121 tgtacaaata tgataatata aattacataa agatatataa atagaggggg attataaatt
    27181 tgttaaatga aaagaatcta aagaacataa agaatatatt acaaatggta caaatgaaac
    27241 accttaaaga ttttgaaaat tggggaatta ataaacgaaa aaaagaaact gctataaata
    27301 gcttgataaa cataatacaa aatgatggag aaaaactaga ttattttaag gaatggatat
    27361 caatctttac aatagatggt cataataatt attatgtttt taattacaat gattctgact
    27421 tggaattgga agatttaaaa aacatagtag aagatatagt aagtgaaaat ttattggaga
    27481 ttgatactag tgatttagaa gaaactaagg tcatatataa aaaaaatgat gtcataaaca
    27541 aaagattgat tataagattt atttctccag ctttaattag ctgtaaaaat gaaaatgaga
    27601 atgggaatat agaatctgga ttagaaaaaa ctttttattt tgcaacttta tttctagact
    27661 taagtttgaa acaaataata gtttctatac cacatactgt aggtataaaa agcatagata
    27721 atatagaggc taaagcaaga gatttctcag aaatagcaaa atattatgta tcaaaattag
    27781 aagatttgtt aactacttat aatatacaaa tagaaaaata caatgattgg atatatgatg
    27841 ctacatatga gcttgctgag gaaggcagtg ctcataataa tcctgagata aacaaaaaat
    27901 atgaagaaaa tattgataaa atagatgaat tcgcaaaaaa gatagctatt gcttctggaa
    27961 taactgataa ggctataata gaaaatttca aagagggagt gggaatactc tatgagaata
    28021 ttctaataga cgaatttggt gtggtagagg atgaaaatca atacagtact tttgtgcaaa
    28081 atggtgatgg agtaaattca tactgtagag ttgggtctaa aacagcaacc ctaaaatcag
    28141 gaaagggaca tgctatagcc aagacatcta gaaacaatga ggatgtcaag aatttaggtg
    28201 tcatgaaatc attcaatgga actttatcca gatttttaat tgaagtctta gataaagaat
    28261 tatatttaat aagaacagac acttctaaat ttatagaaga gagggtgatt tatgatgtta
    28321 tacgaaaagt tggagaatat aagtatactt ttaggaaatc agagtaaagc aaaatctata
    28381 atagaagaat tagagaaatt aatgaagagt gatatcatta caccaagatt gctggccagg
    28441 aaaactaaag ttacactttt agaggctaca agagttcttg aatttttagt taaagaaaat
    28501 gaattagaat tttttattgt tgttgaatgt tctaatccag atagcgtata tgaaaatgaa
    28561 ataggtcact ataaatactt cacttcgata aaagaattca atgctttttc aaaaggacaa
    28621 gaatgcccaa tatgtggatg tggttataaa tacaactttg aagatacaaa aataggcttt
    28681 agaagattgg agaagtgata cagtgagtct agatacctta aaagaatatc taagcatatg
    28741 tgatgataat ttaatttggg agccttttta tgatgacagt atgctattag acgaattctc
    28801 taattatata aaagaaatag aattatctaa ggaatggaat aaatctaaaa atcatgagaa
    28861 aggaaaaatt ttagaacaat tagtaagatt tataatgtct agatttacaa tattaagtga
    28921 tatatctgta aataagtcta caacagataa tgagctagat gtttttgtta agtttaatga
    28981 caacatacca ataccattct tatgtaatat aaaatcaaaa atagtatgtg aatgtaaaaa
    29041 ctggaaaagt agaaaagtgg atgtaggaat ggtatctaaa ctagcagaaa tatgcaataa
    29101 aaataatgcg ggattgggca tatttatttc tttaaatgga ttgacaggta aggggtggca
    29161 atatgctgaa ggaaaaagaa gaaaattata tttatcagat aagatgccaa taatatcgtt
    29221 tacagtagat gaaataacga aattaaagta taaaaggtat aatcttctga ctatgataaa
    29281 atgtaaaatg caagcattaa tagatgagat ggaatttgct ggaggagaat taagattatt
    29341 agaaagtgaa cttggattta tagactgttt aaatgaaaat atagaatctt tgaaaatgtt
    29401 gggtttaata accgaagttg aatataacaa tattaaagta agaatcaatc atagatatga
    29461 tattgtaaac tgagaactcc aaacgagttc tttttttatt cccaaaacga caaacaaacg
    29521 aggtggtggt gtgcaagatg tgaaagaaaa agtaaaacaa gattacctaa aaggtatgaa
    29581 acaaaaggaa atatcagcaa agtatgacat tagtttaaat actttaaagt catggataaa
    29641 aagatacaat tgggctaatg agaaaaagaa gggtgcacct aaaaataaaa gaggtgcacc
    29701 cataggtaat aaaaatgcca ctggtcctcc tggaaataag aatgctgaaa aatttggttt
    29761 cttctcaaaa tacttacctg aagaaaccca agacttaatt aatgagataa aggataaaga
    29821 taaatttgat attctttggg aacagataac aatacaatat gcagcaataa taagagcaca
    29881 aaagataatg tatgttaaag acaaggaaga aatgattaag gaattaaaga aatatgaaag
    29941 cacagaaaat ggtgagaaga tagagtatga atttcaattt gcatgggata ggcaagcatc
    30001 ttttcttaat gcacagagta gagcaatgag tgaacttaga agtttaatta aacagtatga
    30061 tgaaatgatt cataaggatt ggaatttggc tacagaggag cagaaaacaa gagttgagaa
    30121 gttgaaatgt gaagttgata acctaagtaa agatgatatt ggagatgatg agttgaaaat
    30181 aagtgtagat tatggtgata gaaatgatag ttagaataga ttttaatcca gatttcaagg
    30241 aagc
//
LOCUS       DAEPID010000046        30165 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.046, whole genome shotgun sequence.
ACCESSION   DAEPID010000046 DAEPID010000000
VERSION     DAEPID010000046.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 30165)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 30165)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..30165
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.046"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            32..1144
                     /locus_tag="KR257_002339"
     CDS             32..1144
                     /locus_tag="KR257_002339"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422841.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF5009 domain-containing protein"
                     /protein_id="HBH0031022.1"
                     /translation="MNSRIKSIDIIRGLSIALMIVCNNPGTWMRMYPQLRHAVWHGVT
                     LADFAFPFFVISLGVTIPISINSKLKNNKSTLSIILSIFKRSILLILFGFFLNYLGNP
                     DLDTVRILGVLQRMGLVYFVTSLAYLLLKKLNVGSTATIITFLCIATFIIVGYYILAK
                     PYGFELEGSLAQLVDLHFFKGHLYKPEFEPDGFLTSIVAISSGMLGCTMGCVLLKENL
                     GEYKKFFKILVMSIILLIGAFIFNQYFPFNKRLWSSSFVLLMAGSYGILLSIFYFICD
                     IKNKSKIFTPIIALGSSPIFTYMCLEILSHVFWNVPKLTNKVDYPTTLVEWTTYELIT
                     PWAGTTWDSLIFSLLYVLFWVIVMSIMYKKKIFIKI"
     gene            1398..3422
                     /locus_tag="KR257_002340"
     CDS             1398..3422
                     /locus_tag="KR257_002340"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009906102.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="N-acetylmuramoyl-L-alanine amidase"
                     /protein_id="HBH0031023.1"
                     /translation="MKKTTKLLATGMLSVAMVAPNVALAAENTTANTESNSDININLQ
                     RKSVVLGSKSNASVKFKEKLNADSITLNFMCYDMPLEATLNYNEKTDSYEGVINYNKD
                     PEYLNVWELQSIKINGKDEQKVLNKEDLESMGLNLKDYDVTQEFIISDANSTKAVNEY
                     MRKTSAPVKKLAGATRFETAVEISKQGWKDGSSKVVIVNGELAADGITATPLASTYDA
                     PILLANKDDIPESTKAELKRLNPSDVIIIGDDGSVSQKAVSQIKSAVNVNVTRIGGVD
                     RHETSLLIAKEIDKYHDVNKIYIANGYAGEYDALNISSKAGEDQQPIILANKDSVPQG
                     TYNWLSSQGLEEAYYIGGSQSLSSKIIDQISKIAKNGTSKNRVSGADRHETNANVIKT
                     FYPDKELSAMLVAKSDIIVDSITAGPLAAKLKAPILITPKTYVSAYHNTNLSEKTAET
                     VYQIGDGMKDSVINSIASSLSKHNAPTEPDNSGSAAGKTVVIDPGHGGSDSGATSGLN
                     GGAQEKKYTLNTALATTEYLRSKGINVVMTRDTDKTMALGERTALSNTIKPDLFTSIH
                     YNASNGAGNGVEIYYKVKDKNGGTTKTAASNILKRILEKFNMKNRGIKTRTLDNGKDY
                     LYVLRNNNYPAILVECAFIDNKSDMDKLNTAEKVKTMGTQIGIGIEDTVK"
     gene            3642..4328
                     /locus_tag="KR257_002341"
     CDS             3642..4328
                     /locus_tag="KR257_002341"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891044.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sugar transferase"
                     /protein_id="HBH0031024.1"
                     /translation="MSGYTNDECEIPKIKSYPGADKEIASEIDYSIVKGTVLFDLYQR
                     IMDLVLSIIGLVIGLPLIAIFGILIKIEDKGPITYKQERLGKCGRRFYIYKLRSMRTD
                     AEKFGAQWAEKDDPRITKVGKFIRKTRIDEIPQLFNILKGDMGLIGPRPERPNFTVQF
                     NEEIPGFINRLAIKPGLTGWAQVNGGYEITPEEKLKEDIYYIKNRSILLDFKILFKTV
                     KVVLTGDGAR"
     gene            4423..5478
                     /locus_tag="KR257_002342"
     CDS             4423..5478
                     /locus_tag="KR257_002342"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861676.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell wall-binding protein Cwp7"
                     /protein_id="HBH0031025.1"
                     /translation="MIKKISTILSLVLLISISSTIGVFADANPKRELIEGSIPEISTE
                     LNKRAFKDSKEVILVNEESIVDSISATPLAYAKNAPIVVTKSKNLGRVTRNYLKELGP
                     EKVTIVGGLKAVSKDAERNIEKMGMKVERIRGKDRYDTSLKIAREMYRTVGFDEAFLL
                     SSTTGLENAISVYSYAAKSGMPIIWAKDEGFEEQIDFLKGKNLKKIYALGDSKEFIAE
                     IDSNLKNIEGIKQINKSSTNVDLIKKFYDEKDIKKIYTARLDFGSRSDVNEYISLGVV
                     SAKENMPILICSDNLSRAQDKFLKDSNINDVVEVGYTVGDYSLFKSIFNLTFLSCIVL
                     ILLLLLITFRALRYESK"
     gene            5593..7149
                     /gene="murJ"
                     /locus_tag="KR257_002343"
     CDS             5593..7149
                     /gene="murJ"
                     /locus_tag="KR257_002343"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454106.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="murein biosynthesis integral membrane protein
                     MurJ"
                     /protein_id="HBH0031026.1"
                     /translation="MSKTAKAALWIMAATMFSKVLGFLRELVLANFYGTGMYADVFVL
                     TLNIPGLIIAVIGSAVATTYIPMYFETKKRLGDEGALKFTNNVLNICYIMAIVIAIIG
                     LLFTEQFVTVFAAGFRNDPAKFQAAILFTKIMISGVLFLSGSKIFSSFLQVNDSFVIP
                     GLIGIPYNIIIIAAIALSAGKNVWILPAGALLAMASQLLFQLPFAFKKSYKYKPYINL
                     KDESIKELVNLVLPMLVGVAVGQLNIFVDRLLATTLGDGKLSALNYANRLNEFVMALF
                     VTSIITVIYPKLAKMSGKDNKEGFISTIVKSSNCIILVVLPISIGAIILAEPLVRILF
                     QRGKFDALSTDLTSIALRLYSLGLLACGVRDVLYRAFYSLSDTKTPMINGSIALIINI
                     VLNLILIRPLGHAGIAISTSTSNIITVILLFISLKKKNGYFGGDKIIKTGLKSLVASG
                     VMAVATLLIYNNLYAFMGSGTIKEIISVGAGVLGGASVYTVLIVLFKVEEMDLAFEFL
                     RKGKQKLLRR"
     gene            7195..8901
                     /locus_tag="KR257_002344"
     CDS             7195..8901
                     /locus_tag="KR257_002344"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897940.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phospho-sugar mutase"
                     /protein_id="HBH0031027.1"
                     /translation="MDYKNNYEMWLNSPYFDEQTKNELLSIKDDEKEIQDRFYKNLEF
                     GTGGLRGIIGAGTNRINIYTVRRATLGVLNYIMKTQGEEGKQKGIVIAHDSRYMSREF
                     CIEVAKTLSAYGVKAYIFEELKPTPELSFAVRYLKCAMGIVITASHNPKEYNGYKVYD
                     SDGGQICIDMANDIIAEVNKIDDYSTIKSIDFEEALSKNLITILDNEVDDEFIKAVKK
                     QVLRQNIIDEYGKKLKIIYTPIHGTGNKPVRKVLNECGFENVMVVKEQELPDSNFSTV
                     KYPNPEEKSVFNIAIEMAKNNGTDLIIGTDPDCDRVGIVVKDSSGEYVVLNGNQVGSL
                     LVRYILESLVEENKLPKNNPTIIKTIVTSELGAKIAKAYNVDCLNTLTGFKFIGEKIK
                     AFEESNDRSFIMGYEESYGYLIGTHARDKDGVVSSLMICEMAAYYSSKGMNLYEALID
                     TYNKFGYYKEDLKSVTLKGIDGIKKIKEMMLYFRSVKIDNVADVKVDKILDYKDGVDD
                     LPKSDVLKFLLEDGSWIAIRPSGTEPKIKFYFGANSDNQEDVEFKLNNLISYILNVVD
                     SI"
     gene            8923..9996
                     /locus_tag="KR257_002345"
     CDS             8923..9996
                     /locus_tag="KR257_002345"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426511.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="mannose-1-phosphate guanylyltransferase"
                     /protein_id="HBH0031028.1"
                     /translation="MKVYNVIMAGGGGTRFWPLSRQEVPKQLINLSGEDALINETINR
                     IDSLAKKDDLFIVTNEKQLEALKDIVKDKCLDSNILPEPCARNTAAAIGFAAFNIMKK
                     YGDGVMCVYPADHYIKDEKEFKSILEKAIYIAENNDKLVTIGITPTFPSTGYGYINFN
                     RENTIEDVAYEVVEFVEKPNYEIAKEYVNSKKYVWNSGMFVWKVSKILEDFKRYLPKV
                     YEKLEDISKYLGTKEEMEKIKEIYPTIQSISIDYGIMERSNDVIVVPGDFGWNDVGSW
                     DSLGAIYPTDDEGNIKRGENITIDTKNSIIYSDDKLISTIGISDLIVVSTNDAVMVCR
                     KDKAQDVKKIVEQLKEEDRQEYM"
     gene            10008..10730
                     /locus_tag="KR257_002346"
     CDS             10008..10730
                     /locus_tag="KR257_002346"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897939.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase"
                     /protein_id="HBH0031029.1"
                     /translation="MIPKKIHYVWFGGPKGNIENICINSWKEKLPEYEIVEWNEKNFD
                     IEKEIKGNKFLEECYKRKLWAFISDYTRIKVLYEQGGVYMDTDMQILKDITPLLENNR
                     LVCGYEDDREYINGAIIGVEKGHPFLKDLLEYYEKEVLTSSLFTIPKIMTHLMEKNYK
                     KIDPNNYEEGIRVYDKEYFYPFGFKEDFTPECITENTFGIHWWGKSWAKKRNYFLESK
                     HLTGVNKIWKCCKIFASNTLRS"
     gene            10746..11903
                     /locus_tag="KR257_002347"
     CDS             10746..11903
                     /locus_tag="KR257_002347"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897937.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="polysaccharide polymerase"
                     /protein_id="HBH0031030.1"
                     /translation="MKTLNDDRNIMIRKYLYIFVLFIILLRKYMISFIDPNMDIGMIK
                     SALFYSSIGILMLLFLFDKRKSITEMVLVGVCVLLYLLNREGAILLIVLLAVSAKQID
                     DKFIVKNYLIISACFLMVAILLFNLFPSLIFNQEVHYRYIEKIDMLVTRMDFGLGNPN
                     SVFYHMVTIYAAYIFLRYKDYNKWDRILLFGSAFFVYQTTYSRTGFFTILAGLIFVEI
                     IRWIDIKKIKGLPMLLKTLPVILTLFSVIIGTVFDKSTLLNRLLASRPKFWNVYLAEK
                     GNFLKPFGNSYSPAIKATNPLDSSYVYIISVLGVVACILFMYLMYKGIESFIEKDKKA
                     YLVALFIFLLYSFAENLLLEASFSFAVVLLIKEVILNDKREIDLWKMKSRR"
     gene            11906..12745
                     /locus_tag="KR257_002348"
     CDS             11906..12745
                     /locus_tag="KR257_002348"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009906099.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase family 2 protein"
                     /protein_id="HBH0031031.1"
                     /translation="MLISLIMPTLNRYDDIYLLMDSLENQTYKNFELIVVDQNDNSKV
                     KEIVDKYIDKLDIKYIKSSKKGLSYNRNVGIDNAVGQIIGFPDDDCVYENDTLEKVIN
                     FFNKNKDYKIYSCKTMDSNKVDAFKKMYDGTCDITSSNVLDTITSITFFIDFEGKDYT
                     RFDEKLGVGGEFGAGEEIDYVLNLLSLGFKGKYFGNDIIYHPAKKHSKSKEKYQKDYN
                     YGRGFGALCKKEIVYRKNYKFAKVMVSKLVRNIGGLILSSNRDYHSATIKGRINGFRQ
                     YKL"
     gene            12760..13935
                     /locus_tag="KR257_002349"
     CDS             12760..13935
                     /locus_tag="KR257_002349"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728923.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CDP-glycerol glycerophosphotransferase family
                     protein"
                     /protein_id="HBH0031032.1"
                     /translation="MDKVKFLINMLLAFFIYPFNKHKFNGRDIWLIGGHSGDIYNDNS
                     KFFYEYMLKEHNDVETYWVVNKDSKVFDKIPGKKLIRGSVENYLYYYNSKAIVFSHAP
                     SADIAPYNFAVPVLNYFHKKTIKVFLNHGTISFKKRKPMNKKFKNIIDNLYKSYNIVT
                     ASSEFERNVMVNDWGMLDDSVYIIGNARYDNLPTNEVAQTRDILYTPTWRDWIKFSSG
                     KFTDTDYFKNIMNFLNDDKLNKILDEKDINVKIYMHHLMHEFIDDIKENITGKRIVFL
                     DKGVTLANEIRKSAANITDYSSVAIDFLYMNRPILFYQFDLDEYMEKVDSYIDLKSEM
                     FGSLAYNNDEAVNKLIDIIENNFEVMDNQKNERNKFFRYNDNKNCKRIYDCVLSKIK"
     gene            13964..14713
                     /locus_tag="KR257_002350"
     CDS             13964..14713
                     /locus_tag="KR257_002350"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426502.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase family 2 protein"
                     /protein_id="HBH0031033.1"
                     /translation="MKKNLVSIITPMYNSEKFIEATIKSVLNQTYQEWEMLIIDDCST
                     DNSPNIVKSYMQQDSRIKCIKTETNKGVSNARNLALSKATGQFIAFLDSDDQWNSSKL
                     EKQVNFMLENDYVISFTSYELMDENDKKLNKVIKVPPNVDYRRLLKGNILGCLTVVID
                     KSKLDFEIRMSGVRHEDYVLWLSILKKGHIAHGINEVLALYRKSSNSLSGNKIKAAMW
                     TWNIYRNIEKIPLYKAIYYFINYGINGIKKS"
     gene            14735..15643
                     /locus_tag="KR257_002351"
     CDS             14735..15643
                     /locus_tag="KR257_002351"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426500.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase family 2 protein"
                     /protein_id="HBH0031034.1"
                     /translation="MYKYKFTVFTPTYNRAHLLENLYNDLKAQTYDFNDFEWLIVDDG
                     SSDSTKELVEKFISENKLNIRYIYKENGGKHTAINLGVKNADGELFFIVDSDDGLIKD
                     SLEIANDEWDSLENKEGFSGVVGLCVYPSGDLIGTEMPEDKKICHFADLYFKYGVKGD
                     KSIVFVTDELIKFPFPERKEVRFLPESVVWNEMSKYYKVICVNKPMIIRDYLDDGLTK
                     NILSKNALRGRALEFLYLINQNTYPLSRYPYMWIKNYINLARYSLLSDSHYFGELRKV
                     SDKLLYLALFPLGYYKYIGQRKLVSK"
     gene            15691..16443
                     /locus_tag="KR257_002352"
     CDS             15691..16443
                     /locus_tag="KR257_002352"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422866.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase family 2 protein"
                     /protein_id="HBH0031035.1"
                     /translation="MNEPLVSIITPVYNSEEFLSETIKSIQNQTYKNWQLLLVDDCSK
                     DNSSEIIKSFRKEDARIKYIKLEKNSGAAVSRNVGIKNAEGRFIAFVDSDDLWDSRKL
                     EIQIEYMLKENVGFSFTSYRYMRQDGSKTNKVARAPKKIDYEGLLRNTIIGCSTVVID
                     KEIVGEFSMPLVRRGQDTATWLQLLKKEKYAYGIQEDLVNYRLVGNSISSNKIKALKR
                     TWNTYRNVENLSLPKSLYVFCFYVFNAIKKRV"
     gene            16421..17764
                     /locus_tag="KR257_002353"
     CDS             16421..17764
                     /locus_tag="KR257_002353"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012816333.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-glucose/GDP-mannose dehydrogenase family
                     protein"
                     /protein_id="HBH0031036.1"
                     /translation="MPLKKEYKFYILGGKKMKIAIAGTGYVGLVTGVCLAEVGNENVV
                     CVDVDEQKVKSMKLGIAPIYEEGLEELMVKNYNRGRIDYTTDYKKAYEDVDVILIAVG
                     TPERSDGSANLDYIKVVAKQIAETVTKDTLVVIKSTVPIGTNEEIEDYINRNLKNDVK
                     VELASNPEFLSQGTAVKDTLHASRIVIGVESEWAREILEEIYKPFNQPIIVTNRNSAE
                     MIKYASNNFLALKISFMNDIANLCEIAGANIEDVALGMSYDDRIGSKFLKAGIGYGGS
                     CFPKDTKALHWLSEHNGYELKTVKAAIEVNESQKLKLVRKASKLVESFQDMKVAVLGL
                     TFKPDTDDIREAPSIPNIKYLLERGARVTVYDPIGVNNTKKIFGDSILYADSVDDAIE
                     DAEICFIMTEWKDVLNYDIHKYKEKMKNPLVLDGRNCYKIKDMEELGIEYYSIGR"
     gene            17770..18861
                     /locus_tag="KR257_002354"
     CDS             17770..18861
                     /locus_tag="KR257_002354"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728922.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase"
                     /protein_id="HBH0031037.1"
                     /translation="MKTVCYLADGSNPHTLKWCSFFKNKGYDIHVISLNGGHMEGIKI
                     YNFGSNVEELKNENISKKTGYLGSIKQIKKLVNEIKPDILHAQYASSYGFIGSLLGYH
                     PYIISVWGTDIYDFPNNGFIQKQIIKHNFRKADYIFSNSRDMAKEANKYTAKHVDVTF
                     FGVDMDRFKPMEVEKEDAFVIGIIKSLEKKYGIEYLIQAFKMLKDEYKDKKIILKIGG
                     SGSQMDNLINLAKELGIENDVQFLGRISPENVSKTFNSFDVTVFPSLREGFGVAAIES
                     EACEVPVIVTNVGGHPESVWENETGLIVEPKQPEEIKNAIIKLMENDELRLNMGKKGR
                     QFVRENYEVNLNFNDIEKIYDSIFDKYKK"
     gene            18945..20858
                     /locus_tag="KR257_002355"
     CDS             18945..20858
                     /locus_tag="KR257_002355"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728921.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="polysaccharide biosynthesis protein"
                     /protein_id="HBH0031038.1"
                     /translation="MRESIDLEKESFFNRLFKKYKFRHLTLLILDICSVLVAFRMSLS
                     LTGNLNAFTTNDIIISVCIYIVLHIVSFRLFKCYNTLWRYAGEEEIISIFVATLAYLI
                     PIYIINKLLGFDYPIMFYVLNTIFIIMFTSGARIAYRAIRIVMNKTYSRGKVSNILII
                     GAGDAGEMVIQELKRNPELKKVAVAIIDDDKNKIGRIIHNVKIVGTTSDIKDVVEKHN
                     VDEIIFSIANIEKRRKKEIIDVCKNTNCKIKTIPGIYEIIDGKVDIKQIREVEIEDLL
                     GREPIKTNLREISNYIEGKVILITGGGGSIGSELCRQIAGFNPKELIIVDNYENNAYS
                     IQQELLRKYKNKLDLKTVIASIREEKRMDEIFNKYKPEVVFHAAAHKHVPLMESSPGE
                     AIKNNIFGTLNIAGLSSKYRAKKFVLISTDKAVNPTNIMGATKRAAEMIIQTMNAESQ
                     TEFVAVRFGNVLGSNGSVIPLFKKQIEDGGPVTVTHPDIIRYFMTIPEAVGLVIQAGA
                     MAKGGEIFVLDMGEPVRILDLAKNLIKFSGFEPDVDIKIEFSGLRPGEKLYEELLMSE
                     EGLLDTEHKKIFIGRPIDVDREKITKYLKLLREITNNEEVEKIDGIMRELVPTYIKPE
                     DANIKEIATTREK"
     gene            21057..21764
                     /locus_tag="KR257_002356"
     CDS             21057..21764
                     /locus_tag="KR257_002356"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422873.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="C40 family peptidase"
                     /protein_id="HBH0031039.1"
                     /translation="MMNIKNKKHILKKFIAMVLIAGVVTVEAGAITASAAEPTNSPMS
                     ATVDQCDFLNVRSGASANDAVVGKINTGDKVEVLELHSNGWIKIKSVDNVTGWVNGDY
                     LTIQGGNVDAKVQNVLNLAFKQQGKPYRWGATGPNAFDCSGFTSYVYKNGAGVNLPRV
                     SRSQATVGKKVSRAELKPGDLVFFGSGGSINHVGLYVGDSKFIHSPQTGDVVKVTSMA
                     PGTNYARRLITATRVLQ"
     gene            22066..24177
                     /locus_tag="KR257_002357"
     CDS             22066..24177
                     /locus_tag="KR257_002357"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861673.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell wall-binding glycosyl-hydrolase Cwp19"
                     /protein_id="HBH0031040.1"
                     /translation="MKKISILVLSLIMTLTMCSVSSFADSSNDKEMRAAWISTVYNLD
                     WPKTKNNEAKQKKEYTDLLDKLKSVGINTAVVQVRPKSDALYKSNINPWSEYLTGTQG
                     KDPGYDPLPFLIEEAHKRGMEFHAWFNPYRITMADESIDKLPANHPAKKNPSWVVKHG
                     NKYYYDPGLPEVRKYIVDSIAEVVQNYDIDGVHFDDYFYPGVSFNDTATYQKYGKGQN
                     KDDWRRENVNTLLRDVKASIKSIKPNVVFGVSPAGIWRNKSSDPTGSDTSGNESYVGT
                     YADTRAWIKQGLIDYVVPQLYWPIGLKAADYSKLVAWWANEVKGTNVDLYIGQGIYKQ
                     GQSSYGGQNIAKEIVQQVTLNRKYSEIKGSMYFSAKDIANSTSIQKDLKSLYSSSEEP
                     VTPPSNVKVEKLRGDERYDTAVAISKKGWATNSDTVVLVNGYSIVDGITSTPLATSND
                     APILLVNKDNIPTSTKNELKRLNPSKVILIGGNNSIGDKVESEIKDTLSNVSINRVGG
                     SDRYSTSLMIAKELVKTNPVEKLYITSGTGEADSLSIASKAGEEKQPIVLVSKDNVSD
                     EVYNWISDLKVKDAYFIGGNLSISDSVINKLDKVITNDVSKNRIAGENREETNGKVIQ
                     KFYPNAEYSSMFVSKSNQLVDALTSGPLAAKLKSPVVMLGNSVTSAQKTALEPKKTTL
                     VYEAGDGINQNTLNTFLNLVK"
     gene            complement(24375..25340)
                     /locus_tag="KR257_002358"
     CDS             complement(24375..25340)
                     /locus_tag="KR257_002358"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454115.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LCP family protein"
                     /protein_id="HBH0031041.1"
                     /translation="MSKLKKFVILLAFLVVIFPISVYGYFYYKLSAIHDSSISSDLLD
                     NNDHKNEDGIINILLMGTDARPNEDSSRSDAMMILTIDNKHNDIKLTSLARDSYVDIP
                     GHGKQKLTHAYAYGQADLLIQTIEENFNIDIQNYACVNFESFMYIIDAIGGVEVTVEK
                     GEIRELNKFIPETYKWSKSDDKGSIQYIRNSGKQTLNGYQALSFARIRHNDTAFARDG
                     RQRQIIQAIIKKTETLPVTKYPGLLDAVLPYVKTNMKPNAILSLGAQVLKMGDLNIKQ
                     FEFPIDDEIHSTGGIYGKAGWVLRFDPDTLDILHDFIFNDIEFKQ"
     gene            complement(25625..26581)
                     /locus_tag="KR257_002359"
     CDS             complement(25625..26581)
                     /locus_tag="KR257_002359"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891022.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LCP family protein"
                     /protein_id="HBH0031042.1"
                     /translation="MSGLKKFVIFLALLVIAFPVSIYGYVFTKLKTIQDDSINTEALS
                     SNDYKNEENITNILLLGTDARPGEEVSRSDAMMILTIDNKNKSLKLTSLNRDTYVNIP
                     GHGEQKLTHAYVYGQANLLIETIEENFQLDIQNYAVVDFFSFMDIVDALGGVTVTVDK
                     SEIRELNKFIPETYKWNKNDNKGSLKYIRNSGEQKLNGYQTLAFSRIRKNDSTDERDR
                     RQRSVIQSLINGVKDLPVTKYPNLVNTILPYVKTNMNPNEIISLGKELLSIGNLNLKS
                     MEFPLSTENGRKIGNAGYVIPFEEYELDAMHDFIFKDIMVED"
     gene            26949..27737
                     /locus_tag="KR257_002360"
     CDS             26949..27737
                     /locus_tag="KR257_002360"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893724.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Cof-type HAD-IIB family hydrolase"
                     /protein_id="HBH0031043.1"
                     /translation="MIKLIATDLDGTLLDEKSEINPEFYKVFKKLRERGIMFSAASGR
                     QYQNLIKKFEDIKDDMMFISENGTLVVYKGKEILSNPLNKELVNEIIETTRSIKGKKI
                     VMSGKKYAYIESKDEAFIQEVSTYYAKFKIVEDLTKVEGDILKIAVFDFKGAEHNNNI
                     YFEKFSDRAQVCISGVEWLDLTAKGANKGSAIKKVQKMLDIKYEETMVFGDQLNDVEM
                     MKSAYHSYAMENANEHLKQIARFRAKRNTENGVVDKIKEVIKIG"
     gene            complement(27860..28330)
                     /locus_tag="KR257_002361"
     CDS             complement(27860..28330)
                     /locus_tag="KR257_002361"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891020.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4358 domain-containing protein"
                     /protein_id="HBH0031044.1"
                     /translation="MKKILILFFSIILSLGMVSCSSSGDYKNVSTSKIKKALKSSDLL
                     IKESKIFDAKDFNYFNDVEEDIIQGFVINSSEKLSLEDIIVIKTDEVDKIYKTLENYK
                     KDMIQAPFGEGHGEKINSEIANNTIIEKAGRYVYLISAENATQIENKILNIIKK"
     gene            28469..29113
                     /gene="uppS"
                     /locus_tag="KR257_002362"
     CDS             28469..29113
                     /gene="uppS"
                     /locus_tag="KR257_002362"
                     /EC_number="2.5.1.31"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422884.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="di-trans,poly-cis-decaprenylcistransferase"
                     /protein_id="HBH0031045.1"
                     /translation="MRIPKHVGIIPDGNRRWASQNGMTKDKGYESGIDPGLESYRLCR
                     DLGCEEVTFYGFTTDNTRRPSVQTKAFTKACIDAANILIDEGAALLVVGNTKSPMFPE
                     ELLPYTNRIKAKEGQIKANLLVNYGWYWDLNNISGVENVNKNNIQDYIQSFDVSRLDL
                     IIRWGGRRRLSGFLPVQSIYADFYVIDNYWPDFKSDDIKDAFSWYDTQDVTLGG"
     gene            29156..30061
                     /locus_tag="KR257_002363"
     CDS             29156..30061
                     /locus_tag="KR257_002363"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861670.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="N-acetylmuramoyl-L-alanine amidase"
                     /protein_id="HBH0031046.1"
                     /translation="MKKKLLDGKITLIICKSVKIYTKKGEEMSKGNNNNNSRNKSKKT
                     SHLNRKKRKLNKKKLAVLICFTVLFLFIAFKATQGVVALVKSMDKSNKTSQQQNVNSE
                     QFDLGNEEENKKKKYTVFIDPGHGGNDKGTESKTSNRYEKDLNLQIAKKLANKLSKQK
                     DIQVVVSRTDDTYISLKDRAILANNSSADVLVSIHLNAEKNGNTATGIETWYRNKATD
                     GSKELAQTVQSTIVSYVKVRDRGIVENNFEVLRESNMPAILIECGFLTTPSEEQKIIN
                     EKYQDQLAEGIVQGVLSYLDSKGNK"
BASE COUNT        11954 a         3293 c         5371 g         9547 t
ORIGIN      
        1 aatttcaaat aatgctgtag attctaaact tatgaatagt aggattaaat caatagatat
       61 aataagaggg ctatcaatag ccctcatgat agtctgcaat aatcctggga cttggatgag
      121 aatgtatcct caattaagac atgctgtatg gcatggtgta acacttgcag attttgcatt
      181 tccttttttt gttatatctt taggtgttac aattccaata tcaataaata gtaaactaaa
      241 aaataataaa tccacactga gtataatact tagtatattc aagagaagta tcttattgat
      301 attatttgga tttttcttaa attacctagg aaatcctgat ttagatactg taagaatact
      361 tggagtactt caacgtatgg gattagtcta ttttgtgact agtttagcat atttactgct
      421 aaaaaaatta aatgttggaa gtactgctac aataattact tttctatgta tagctacatt
      481 tataatagtt gggtactaca tcttagcaaa accttatgga tttgagctag aaggttctct
      541 tgcacagtta gtggatttac atttcttcaa aggacatttg tacaagccgg aatttgaacc
      601 agatggtttt ttaactagta tagtagcaat ttcttcaggt atgttgggat gcactatggg
      661 atgtgtactt ttaaaagaaa acctaggaga atataaaaaa ttctttaaaa tactggttat
      721 gagcataatc ctgctaatag gtgcttttat ctttaatcag tattttccat ttaataaaag
      781 attatggtct agctcatttg tacttttaat ggctggcagt tatggtatat tactgtcaat
      841 attttatttt atatgcgaca tcaaaaataa aagtaaaata tttaccccaa taatagcact
      901 tggaagtagc cccattttta catatatgtg ccttgagata ttgagtcatg ttttttggaa
      961 tgttccaaaa cttacgaaca aagtcgatta tccaactacc ttggtagagt ggactacata
     1021 tgaacttata acaccttggg caggtacaac ttgggattct cttatatttt ctttattgta
     1081 tgtcctattc tgggttatag taatgtctat aatgtacaag aaaaaaatat ttattaaaat
     1141 ttagtgcaat atttttagat gataaagtct ttgatttgtt caaatataca gaaactatca
     1201 aatataatca aaatttctcc tcgataaaat ttaaaaacca tgccataaaa gattacaaaa
     1261 agtttacaat ttgtaatttt ttgtgctata atgaaaaaag atttacataa tattgaattt
     1321 atgtaatata aaacaagctt aagatgtatt aaaaaagatt taaagattta aagaaccaaa
     1381 aaattagggg ggatatgatg aaaaaaacaa caaaattatt ggcaacagga atgttgtctg
     1441 tagcaatggt ggcaccaaat gtagctttag cggctgaaaa tactactgca aatacagaat
     1501 ctaattcaga tattaatata aatttacaaa gaaaaagtgt agtgttagga agtaaatcta
     1561 atgcaagtgt aaaatttaaa gaaaaattaa atgctgattc aataacatta aattttatgt
     1621 gttatgatat gccacttgaa gctactttaa attacaatga aaagacagat tcatatgaag
     1681 gtgtaataaa ctataacaaa gacccagaat acttaaatgt atgggaactt caaagcataa
     1741 aaataaatgg taaagatgaa cagaaagttt taaacaaaga agacttagag tctatgggat
     1801 taaatcttaa ggattatgat gttacacaag agtttataat aagtgatgca aattcaacaa
     1861 aagcagtaaa tgaatatatg agaaaaactt ctgcaccagt aaaaaaactt gctggagcta
     1921 ctagatttga aactgctgtt gagataagta aacaaggttg gaaagatggg tctagtaagg
     1981 ttgtaatagt taatggagaa ttagcagcag atggaattac agctactcca cttgcatcta
     2041 catatgacgc accaatatta cttgcaaata aagatgatat accagaaagt acaaaagcag
     2101 agttaaaacg tctaaatcca agtgatgtaa taattatagg tgatgatggt tcagtttcac
     2161 aaaaggcagt gtctcaaatt aaatctgctg taaatgtaaa tgtgactcgt attggtggag
     2221 ttgatagaca tgaaacatct ttacttatag caaaagaaat agataagtat catgatgtta
     2281 ataaaatata catagcaaat ggatatgctg gtgaatatga tgctcttaat atttcatcaa
     2341 aagctggtga agaccaacaa cctataatat tagctaataa agattctgta ccacaaggta
     2401 catataattg gttatcttca caaggtttag aagaagctta ttacataggt ggtagtcaaa
     2461 gtttatcatc aaaaattata gaccaaatat ctaaaatagc aaaaaatggt acttcaaaaa
     2521 atagagtttc tggagcagat agacatgaaa caaatgcaaa tgtaattaag actttctatc
     2581 cagataaaga gttgagtgca atgttagttg caaaatctga cataatagtt gattcaataa
     2641 cagcaggacc tttagcagct aaattaaaag ctccaatact tataactcca aaaacttatg
     2701 tttctgcata ccataataca aatttatcag aaaaaacagc agaaacagta tatcaaattg
     2761 gtgatggaat gaaagatagt gttataaatt ctatagcatc tagtttatca aaacacaatg
     2821 caccaacaga accagataat tcaggttcag cagcaggaaa aactgtagtg atagacccag
     2881 gtcatggggg ttctgattca ggggcaacaa gtggattaaa tggtggagca caagaaaaga
     2941 aatatactct taatacagca ttagcaacta ctgaatattt acgttcaaaa ggtataaatg
     3001 ttgttatgac tagagataca gataaaacaa tggctttagg agaaagaaca gcattatcaa
     3061 atactataaa gccagattta tttacaagta tacattacaa tgcgtctaat ggagctggta
     3121 atggtgtgga aatttattac aaagtaaaag ataaaaatgg tggaacaact aagactgcag
     3181 catcaaatat cttaaaaaga atactagaaa aatttaacat gaaaaataga ggaatcaaga
     3241 caagaacact tgataatgga aaagattacc tatatgtgtt aagaaataac aattatccag
     3301 caatacttgt tgaatgtgca tttattgaca ataagagcga tatggataag ttaaatactg
     3361 cagaaaaagt aaaaacaatg ggaactcaaa ttggaatagg aatagaagat acagtaaaat
     3421 aaaatagaaa atattaaagc aaaacatatc atctcctgtt ataatgtaaa atataacaag
     3481 agatgatata tttttgtaaa gaatcaaatt gtttacaatg atgtttcttg tattgataat
     3541 ctgctcatta ttgagtataa tatagaaata agtcaaaaat aagatagaaa taagttgaaa
     3601 ttaagaatta aaaaaatttt tattccaata tggaggtaac tatgtctgga tatactaatg
     3661 atgagtgtga aatacctaaa attaaaagct atccaggggc agataaagaa attgcaagtg
     3721 agattgacta tagcatagta aaaggaacag ttttattcga cttgtaccaa agaattatgg
     3781 atttagtttt atctataata ggacttgtga taggtttacc tttaatagca atatttggaa
     3841 ttcttattaa aatagaggac aaaggaccaa taacttataa gcaagaaaga ctaggaaaat
     3901 gcgggagaag attctatata tataaattga gatctatgag aacagacgca gaaaaatttg
     3961 gcgcacaatg ggctgaaaaa gatgatccta gaataactaa ggttggaaag tttattagga
     4021 aaactagaat tgatgagatt ccacagctgt ttaatatatt aaagggggac atgggcttaa
     4081 taggtcctag accagagaga ccgaacttta ctgttcaatt taatgaggaa atacctggat
     4141 ttatcaacag gctcgctata aaacctgggc ttacaggttg ggcacaagta aatggtggat
     4201 acgaaatcac tcctgaagaa aaacttaaag aagatattta ctatataaaa aataggagta
     4261 tattacttga ctttaagata ctctttaaaa ctgttaaagt agtattgaca ggagacggag
     4321 ctagataatt ttaaaatatt agattactaa tcaatgaaaa agctctttaa aaagagcttt
     4381 tttattgtca aaaaatacaa aaaagaaaag gaatgagaac ttatgattaa aaaaatttct
     4441 actatattat cgttagtttt gttaatctct atttctagta cgataggagt atttgcagat
     4501 gcaaatccca aaagagaatt gatagaaggg agtataccag agatttcgac agaattaaat
     4561 aaaagagcat ttaaggattc taaagaagta attcttgtaa atgaagagtc aattgtagat
     4621 agtataagtg caacaccttt agcatatgca aaaaatgctc caatagttgt aactaagagt
     4681 aaaaatcttg gtagagtaac aagaaattat ctaaaagaac taggtccaga gaaggttacg
     4741 atagtaggtg gtttaaaggc agtatctaaa gatgctgaac gtaatataga aaaaatggga
     4801 atgaaagtag aaagaataag agggaaagac agatatgata catctttaaa gatagctaga
     4861 gaaatgtata gaacagtagg atttgatgaa gcatttttac ttagctcaac aacaggatta
     4921 gagaacgcca tatctgtata ttcttatgcc gctaaaagtg gaatgccaat aatatgggct
     4981 aaagatgaag ggtttgagga acaaattgat ttcttaaaag gcaaaaatct taaaaaaata
     5041 tatgcattag gtgattcaaa agagtttatt gcagagattg attctaactt aaaaaatata
     5101 gaaggaataa agcaaataaa taagtcaagt acaaatgttg atttaataaa gaagttttat
     5161 gatgaaaaag atataaagaa aatctatact gctagattag actttggtag tagatctgat
     5221 gtaaacgaat atatttcttt gggagtagta tcagcaaaag aaaatatgcc aatactgatt
     5281 tgtagtgata acttaagtcg tgcacaagat aaattcttga aagatagcaa tataaatgat
     5341 gtagttgaag ttgggtatac agtaggtgat tatagtctat ttaagagcat atttaatcta
     5401 acattcttat cttgtatagt attaatacta ttattactat tgattacatt tagggcactt
     5461 agatatgagt cgaaatagtt tttgatttat aaggaagctt ttcataggtt aaatttactt
     5521 aattagaata atgtttataa gcagttttaa aagttctact tttagagttt aaattagata
     5581 aggagaaaga agatgtcaaa aacagctaaa gcagcattgt ggattatggc agccactatg
     5641 ttttcaaaag tattaggttt ccttagagaa cttgtacttg caaatttcta tgggacaggt
     5701 atgtatgcag acgtatttgt attaacatta aatatacctg gtttaatcat agcagtcata
     5761 ggctctgcag ttgctacaac ttatatacct atgtactttg agacaaagaa aagactcgga
     5821 gatgaaggtg ccttaaaatt tactaataat gttttaaata tatgctatat aatggctata
     5881 gtaatagcta ttattggtct tttatttaca gagcaatttg ttacagtatt tgcagcagga
     5941 tttagaaacg accctgctaa gttccaagca gcaatattat ttactaaaat aatgatttca
     6001 ggagttttat tcctgagtgg aagtaagata tttagttcgt ttttacaggt gaatgacagt
     6061 tttgtaattc ctgggcttat aggaatccca tataatatta taataatagc agcaatagca
     6121 ctaagtgcag gtaaaaatgt atggatactg ccagcaggag cattattggc tatggcgagt
     6181 cagctattgt ttcaactgcc atttgcgttt aagaagtcct acaagtataa gccatatata
     6241 aatttaaagg atgagtctat aaaagagtta gtcaacctag tattgcctat gttggtagga
     6301 gtagctgttg gacagttaaa tatatttgtt gaccgattat tggcaaccac tttgggtgat
     6361 ggaaagttgt ctgctcttaa ctatgcaaat aggctaaatg agtttgttat ggcattattt
     6421 gttacatcta taataacagt tatatatcct aaactagcaa aaatgtctgg taaagataat
     6481 aaagaaggat ttataagcac tattgtaaaa tcttcaaatt gtattatatt ggtggtgctt
     6541 cctatatcta taggagctat tatattagca gagcctcttg ttagaatatt attccaaagg
     6601 ggtaaatttg atgcgttatc aacagacctt acatctatag cgcttagatt atattcacta
     6661 ggtttattgg cttgtggagt aagagatgtc ttatataggg cattttactc tctttcagat
     6721 acaaaaacac caatgataaa tggaagtata gctttaataa taaatatagt tcttaattta
     6781 atattgataa gaccattggg tcatgcaggt attgctatat caactagtac atcaaacata
     6841 attacagtta tattattatt tatatctctt aaaaagaaaa atggatattt tggaggggat
     6901 aaaattataa agactggtct aaaaagtttg gtagcatctg gtgtgatggc agtagctact
     6961 ttattgatat ataataatct atatgcattt atgggttcag gaacaattaa agaaattata
     7021 tcagttggag ctggagtatt aggtggagct tctgtatata ctgtattgat agttttattt
     7081 aaggtagaag agatggattt agcttttgaa tttttaagaa aaggaaaaca aaaactactt
     7141 agaagataga taattacctt gaaattttaa attagagtca gaaaggatga aaatatggat
     7201 tataagaata attatgagat gtggttaaat tctccttatt ttgatgaaca aacgaaaaat
     7261 gagctattaa gtataaaaga tgatgaaaaa gaaatacaag atagatttta taaaaattta
     7321 gagtttggaa caggtggttt aagaggtata ataggagcgg gaactaatag aatcaatatt
     7381 tatactgtta gacgtgcgac actgggcgtt ttaaattata tcatgaaaac tcaaggagaa
     7441 gaaggtaagc aaaagggaat agttatagca catgatagta gatacatgtc tagggagttt
     7501 tgtatagaag tagcaaagac tttaagtgct tatggtgtaa aggcttatat ttttgaagaa
     7561 ttaaagccta caccagaact ttcttttgct gttagatatt taaagtgtgc tatgggaata
     7621 gtaataacag caagtcataa tcctaaagaa tacaatggat ataaagtata tgactcagat
     7681 ggtggtcaaa tctgtataga tatggcaaat gatataatag cagaagttaa taagattgat
     7741 gattacagta ctattaaaag tatagatttt gaagaagctt tatctaaaaa tttaataact
     7801 atattagata atgaagtaga tgatgagttt ataaaagctg ttaagaaaca agttttaaga
     7861 caaaatataa tagatgaata cgggaaaaaa ttaaaaataa tatatacacc tattcatggt
     7921 acaggaaata agccagtaag aaaagtctta aatgaatgtg gttttgaaaa tgtaatggta
     7981 gttaaggagc aagaattgcc agattctaat ttttcaacag taaagtatcc taatcctgaa
     8041 gaaaagtcag tgtttaatat agctattgaa atggcaaaga ataatggcac tgatttgata
     8101 ataggaacag accctgattg tgatagagta ggtatcgttg taaaagattc aagtggtgaa
     8161 tatgtagtct taaatggaaa tcaagtcggt tcacttttag ttagatatat attagagagt
     8221 ttagttgaag aaaataaact tcctaaaaac aatcctacaa taataaaaac tatagttaca
     8281 tcagaactag gtgcaaaaat agcaaaggct tataatgtag attgtttaaa tactttaaca
     8341 ggatttaaat ttataggaga aaaaataaaa gcgtttgaag aaagcaatga tagaagtttt
     8401 ataatgggat atgaggaaag ctatggttac ttaattggaa ctcatgctag agataaggat
     8461 ggtgttgtat cttcacttat gatatgtgaa atggcagcat actattcttc aaaaggtatg
     8521 aacttgtatg aagctttgat agatacatat aataaatttg gatactacaa agaggactta
     8581 aagtcagtaa ctttaaaagg catagatgga ataaaaaaaa taaaagagat gatgctttac
     8641 tttagaagtg ttaaaataga taatgtggct gatgtaaaag tagataaaat tttagactat
     8701 aaagatggtg ttgatgattt acctaagtca gatgtactta aatttttact tgaagatggc
     8761 tcttggatag ctataagacc ttcaggtaca gaacctaaaa ttaaatttta ctttggagca
     8821 aattcagaca atcaagaaga tgtagaattt aagttgaaca atttaatatc ttatatatta
     8881 aatgtagtgg attctatata aaaagctaag gggagataaa caatgaaagt atacaatgtc
     8941 ataatggctg gaggaggagg aactcgtttc tggccactta gtagacaaga agtacctaaa
     9001 cagcttataa atttaagtgg agaagatgct ttaataaacg aaactataaa cagaatagat
     9061 tctctagcaa aaaaagatga tttatttata gtaaccaatg agaagcaatt ggaagcttta
     9121 aaggatatag taaaagataa atgtttggat agtaatatat tgccagagcc atgtgccaga
     9181 aatacagcag cagctatagg ctttgcagca tttaacataa tgaaaaaata tggtgatggt
     9241 gttatgtgtg tatatccagc tgaccattat ataaaagatg aaaaagaatt taaatctatt
     9301 ttggaaaaag ctatctatat agcagaaaat aatgataaac tagtaactat tgggataact
     9361 cctacatttc catcaacagg atatggatac ataaatttta atagagaaaa tactatagaa
     9421 gatgttgcat atgaggtagt ggagtttgta gaaaaaccaa actatgaaat tgctaaagaa
     9481 tatgtaaact ctaaaaagta tgtatggaat agtggaatgt tcgtatggaa ggtatctaaa
     9541 atactagaag attttaagag atacttgcca aaagtatatg aaaaattaga agatataagt
     9601 aaatacttag gaacaaaaga agaaatggaa aaaataaaag aaatataccc aactatacaa
     9661 tcaatctcta tagattatgg tattatggaa agaagtaatg atgttatagt agttcctggt
     9721 gattttggat ggaatgatgt tggttcttgg gattctctag gtgcaatata tccaactgat
     9781 gatgaaggta atatcaaaag aggtgaaaat attactatag atactaaaaa ttcaattata
     9841 tattcagatg acaaattaat atcaacaata ggtattagtg atttgatagt agtatctaca
     9901 aatgatgcag ttatggtttg tagaaaagat aaagctcaag atgtcaaaaa aatagtagag
     9961 cagttaaaag aagaagatag acaagaatat atgtaggagg tgttcatttg attcctaaaa
    10021 aaatacatta tgtatggttt ggtggtccaa aaggaaatat agaaaatata tgtataaatt
    10081 cttggaaaga aaagcttcca gaatatgaga tagtagagtg gaatgaaaaa aactttgata
    10141 tagagaaaga aataaaagga aataagtttt tggaagaatg ttataaaaga aaactttggg
    10201 cattcatatc tgattataca agaataaaag tactctatga acaaggtgga gtttatatgg
    10261 atacagatat gcaaatatta aaggatataa ctcctctttt agaaaataat aggctagtct
    10321 gtgggtatga agatgataga gagtatataa atggtgctat aataggtgta gaaaaaggac
    10381 atcctttttt aaaagactta ttggagtatt atgaaaaaga agtacttact tcttcattgt
    10441 ttacaatacc aaagataatg actcatctta tggaaaagaa ttataagaag attgatccaa
    10501 ataattatga agaaggaata cgtgtttacg acaaagaata tttttatcct tttggattta
    10561 aagaagactt tacaccagaa tgtataacag aaaacacttt tgggatacat tggtggggaa
    10621 aaagttgggc taaaaagaga aattatttct tagaaagcaa acacttaaca ggtgtaaata
    10681 agatatggaa gtgttgtaaa atatttgcaa gtaatacttt acgaagctaa aagggagaaa
    10741 gtaaaatgaa gactttaaat gatgatagaa atattatgat tagaaaatat ctttatatat
    10801 ttgttttgtt tatcatatta cttagaaagt atatgatatc atttattgac ccaaatatgg
    10861 atatagggat gattaaatca gcgttatttt attcttcaat aggaatacta atgctacttt
    10921 ttttatttga taagagaaaa agtataacag aaatggtact agttggagtt tgtgtcttac
    10981 tttatttatt aaatagggaa ggagctatat tattaatcgt tttattagct gtatcagcta
    11041 agcaaataga tgataaattt atagttaaaa attatttaat aatatcggca tgttttttaa
    11101 tggtagctat attattattt aatttatttc cttcattaat atttaatcag gaagtccact
    11161 atagatatat agaaaaaata gatatgcttg ttacaagaat ggattttgga cttggtaatc
    11221 caaatagtgt attttatcat atggttacta tatatgcagc atatatattc ttaagatata
    11281 aagattataa taaatgggat agaatacttt tatttggttc tgcatttttt gtttatcaaa
    11341 ccacatatag tagaactgga tttttcacta tattagcagg attaatattt gtagaaataa
    11401 taagatggat agatataaaa aaaataaaag gactaccaat gctcctaaag acattaccgg
    11461 taatacttac tttatttagt gtaattattg gtacagtatt tgataaaagc actttattaa
    11521 atagattatt agcaagtaga cctaagttct ggaatgtata cttggctgaa aaggggaact
    11581 ttctaaaacc ttttggaaat tcatatagtc ctgctataaa agcaactaat ccattagata
    11641 gttcttatgt atatataatt agtgtactag gagtagttgc ttgtatatta tttatgtatt
    11701 tgatgtataa aggaatagaa agctttatag aaaaagataa aaaagcatat ttagtagctt
    11761 tatttatatt tttactatac tcttttgcag aaaatttatt attagaagct tcatttagtt
    11821 ttgcagtagt attactaata aaagaagtga tattaaatga taaaagggaa atagatttgt
    11881 ggaagatgaa aagtaggagg tagtaatgtt aatatcatta ataatgccaa cattaaatag
    11941 atatgatgat atatacttac ttatggacag cttagaaaat caaacttaca aaaactttga
    12001 acttatagta gtagaccaaa atgataatag caaagttaaa gaaatagttg ataaatacat
    12061 tgataagtta gatataaagt atataaaaag ctctaaaaaa ggattgagtt ataacagaaa
    12121 tgtaggcata gacaatgctg tagggcaaat tataggtttc cctgatgatg attgtgtcta
    12181 cgaaaatgat acattagaaa aagttataaa tttctttaat aaaaataaag attataaaat
    12241 atacagttgc aaaactatgg attcaaataa agttgatgca tttaagaaaa tgtatgatgg
    12301 aacttgtgat atcacaagtt ccaacgtttt ggatactata acatccataa ctttttttat
    12361 tgattttgaa ggtaaagact atacaagatt tgatgaaaaa ttgggtgttg gtggagagtt
    12421 tggtgctggt gaagagatag attatgtttt aaacttattg agtttaggtt ttaaaggaaa
    12481 atactttgga aatgatataa tttaccatcc tgcaaaaaaa cattctaaat ctaaagaaaa
    12541 gtatcaaaaa gattataact atggaagagg ctttggagcg ctttgcaaaa aggaaatagt
    12601 ctatagaaaa aattataagt ttgcaaaagt tatggtatca aaacttgtaa gaaatatagg
    12661 aggtcttata ttgagttcca atagagatta tcatagtgcc actataaaag gaagaattaa
    12721 tggatttaga cagtacaagt tataatgagg atggtgttta tggacaaggt taaattttta
    12781 ataaatatgc ttttggcttt ttttatatat ccatttaata agcataagtt taatggtaga
    12841 gatatctggc ttataggtgg acattcaggg gatatataca atgataattc aaagtttttt
    12901 tatgagtata tgctaaaaga acataatgat gtagaaactt attgggtagt aaataaagac
    12961 agtaaagtat ttgataaaat tccaggcaaa aaattaataa gaggaagtgt agaaaactat
    13021 ctgtattatt acaattcaaa agctatagta ttttcacatg caccatcagc agatatagca
    13081 ccatacaatt ttgctgtacc tgttcttaat tattttcata aaaaaacgat aaaagtgttt
    13141 ttaaatcatg ggactataag ttttaaaaaa agaaaaccta tgaacaaaaa gttcaaaaat
    13201 attatagata acctatataa aagctataat atagttacag caagttctga atttgaaaga
    13261 aatgttatgg taaatgattg gggaatgtta gatgactcag tttatataat tggaaatgca
    13321 agatatgaca atttaccaac aaatgaagtt gcacaaactc gagatatatt atatactcct
    13381 acatggagag attggataaa atttagttca ggaaaattta cggatacaga ttattttaaa
    13441 aatataatga attttttaaa tgatgacaaa ttaaataaaa tattagatga gaaagatata
    13501 aatgtaaaaa tttatatgca tcatcttatg catgagttta tagatgatat aaaagaaaat
    13561 ataacaggaa aacgaattgt gtttttagat aaaggggtaa ctctagcaaa tgaaatcaga
    13621 aaatcagctg caaatataac tgattattca agtgtagcca tagacttttt gtatatgaat
    13681 agacctatct tgttttacca attcgatttg gatgaatata tggaaaaagt tgattcatat
    13741 atagatttaa aaagtgaaat gtttgggtct ttggcttata ataatgatga agccgtgaat
    13801 aaacttattg atattattga aaataatttt gaggttatgg ataaccaaaa aaatgaaaga
    13861 aataagtttt tcagatataa tgataataag aactgcaaga ggatatatga ttgtgtatta
    13921 agtaaaatta aataaatatt ttataaatga tgaggaaggt aatatgaaga agaatttagt
    13981 atctataatt actcccatgt ataattctga aaaatttatt gaagcaacca taaaatcagt
    14041 attaaaccaa acttatcaag aatgggaaat gttaattatt gatgattgct caacagataa
    14101 tagtcctaat atagtcaaat cttatatgca acaggatagt agaataaaat gtataaagac
    14161 tgagactaat aagggtgtct ctaatgctag aaatttagca ctaagtaagg caacaggaca
    14221 atttatagct tttttagata gtgatgacca atggaatagt agtaagttag aaaaacaagt
    14281 aaattttatg ttagaaaatg actatgtaat ttcatttact tcatatgaac tgatggatga
    14341 aaatgataaa aaattaaaca aagtaataaa agttccacct aatgtagatt atagaagatt
    14401 attaaaagga aatatcttag gatgtcttac tgttgtgatt gataagtcta aattggattt
    14461 tgaaataaga atgagtggtg taagacatga agattatgtt ttatggttat cgatattgaa
    14521 aaaagggcat attgctcatg gaataaatga agttctagca ttatatagaa aatctagcaa
    14581 ttccctaagt ggtaataaaa taaaagctgc tatgtggact tggaatatat atagaaatat
    14641 agaaaaaata cctttataca aagctatata ctactttatt aattatggaa taaacggaat
    14701 caaaaaaagt tagacagaga ggaagattta attaatgtat aaatataaat ttactgtatt
    14761 tactccgacg tataacagag ctcatttact tgaaaatttg tacaatgatt taaaagctca
    14821 aacttatgat ttcaatgatt ttgaatggtt gattgttgat gatggaagta gcgacagtac
    14881 taaagagtta gttgaaaaat ttatatcaga aaataaatta aatataagat atatatacaa
    14941 agaaaatgga ggaaaacata ctgcaataaa tctaggtgta aaaaatgcag atggagagct
    15001 atttttcatt gtagatagtg atgatggttt aattaaagat tctcttgaaa ttgctaatga
    15061 tgagtgggat tctttagaga ataaagaagg atttagtgga gttgttggac tttgtgtata
    15121 tccaagtgga gatttgatag ggacagaaat gcctgaagat aagaaaatat gtcactttgc
    15181 agacctatat tttaagtatg gcgttaaggg agataaaagc atagtatttg taactgatga
    15241 gcttataaaa tttccttttc cagaaagaaa agaagtgaga tttttaccag aaagtgtagt
    15301 atggaatgaa atgtctaaat actataaagt tatatgtgta aataaaccta tgataataag
    15361 agattatttg gatgatggtt tgactaagaa tatattaagt aaaaatgcat taagaggtag
    15421 agcattagag tttttatatt taataaatca aaatacatat ccattaagta gatatccata
    15481 tatgtggata aaaaattaca taaatttagc cagatactca ttgttgtctg atagtcatta
    15541 ttttggtgaa ttaagaaaag tatctgataa attgttgtat ttagcattat tcccattagg
    15601 atattacaaa tatattggac aaagaaaatt agtatctaag taaacttgtt ggtatagtac
    15661 tgctagttgc tatataagga gagtaaaaat atgaatgagc ctttagtatc gataattact
    15721 cctgtttata attcagaaga gtttttatca gagacgataa agtcaatcca aaatcaaact
    15781 tataaaaatt ggcagctttt attagtggat gattgttcta aggacaattc aagtgaaatt
    15841 ataaaaagtt ttcgaaaaga agatgctaga ataaaatata taaagcttga aaaaaattct
    15901 ggagctgcag tatctagaaa tgttggtatt aagaatgcgg aaggtcgatt tattgcattt
    15961 gtagatagtg atgatttatg ggatagtaga aaattagaga ttcagataga atatatgtta
    16021 aaagaaaatg taggtttttc ttttacatct tatagatata tgagacaaga tgggtcaaaa
    16081 acgaataagg ttgcaagagc tcctaagaaa attgactatg aaggattact tagaaatact
    16141 ataataggat gttctacagt ggtcattgat aaggagattg taggagagtt cagcatgcct
    16201 ttggtaagaa gaggacaaga tactgcaacc tggttacagt tacttaaaaa ggaaaaatat
    16261 gcatatggga ttcaagaaga tttagtgaat tacagattag ttggaaattc tatatcaagt
    16321 aacaagataa aagcattaaa acgaacttgg aatacttata gaaatgttga aaatttaagt
    16381 ttaccaaaaa gtctatatgt attttgtttc tatgttttta atgccattaa aaaaagagta
    16441 taagttttat atacttggag gtaaaaaaat gaaaatagct atagctggga cgggatatgt
    16501 aggtttggtt acaggtgttt gtctagcaga ggtaggcaat gaaaatgtag tctgtgttga
    16561 tgtagatgaa caaaaagtta aatcaatgaa acttggaata gcacctatat atgaagaagg
    16621 cctagaagaa cttatggtta aaaattacaa cagaggaaga atagattaca ctacagacta
    16681 taaaaaagct tatgaagatg tagatgtaat attaatagct gtaggtacac ctgagagaag
    16741 tgatggttca gccaacctag attatataaa ggtagttgca aagcaaatag ctgaaactgt
    16801 gacaaaagat actctagtag taataaaatc tacagttcca attggtacaa atgaagagat
    16861 agaagattat ataaatagaa acctaaaaaa tgatgtaaaa gtagaacttg catctaatcc
    16921 agagttttta tcacaaggaa cagcagtaaa agatactcta catgcttcaa gaatcgttat
    16981 aggtgtagaa agtgaatggg ctagagaaat attagaggaa atctataagc cttttaatca
    17041 acctataata gttacaaata gaaatagtgc tgagatgata aaatacgcat caaataactt
    17101 cttagctctt aaaatatcat ttatgaatga tattgcaaat ctttgtgaaa tagcaggagc
    17161 taacatagaa gatgtagctt taggaatgag ttatgatgat agaataggaa gtaagttttt
    17221 aaaggcggga ataggatatg gtggttcttg ctttccaaaa gacacaaaag ctcttcactg
    17281 gttatctgaa cataatggtt atgaattaaa aacagtaaaa gctgcaatag aagttaatga
    17341 aagtcaaaaa cttaaattag ttagaaaggc atctaagtta gtagagagct ttcaagatat
    17401 gaaggttgct gttttaggtt tgacttttaa gccagacact gatgatataa gagaagcacc
    17461 atctatacca aatataaaat atttgctcga aagaggggca agagttactg tatacgaccc
    17521 aattggtgta aataatacta agaaaatatt tggtgactct atactttatg ctgattctgt
    17581 agatgatgcg atagaagatg cagagatatg ttttataatg acagaatgga aagatgtatt
    17641 aaattatgat atacataagt ataaggaaaa gatgaaaaat cctttagtcc ttgatggaag
    17701 aaattgttat aaaattaaag atatggaaga gttaggaatt gagtattatt cgataggaag
    17761 gtaaatatta tgaagactgt ttgttattta gctgatgggt caaatcctca tactttaaaa
    17821 tggtgtagtt tttttaaaaa taaaggatat gacattcatg taatctcttt aaatggaggt
    17881 cacatggaag gaataaaaat ttataatttt ggttctaatg tagaagaact aaaaaatgaa
    17941 aatatttcta aaaaaacggg atacttaggt tcaataaagc agataaagaa gctagtaaat
    18001 gaaataaagc cagatatatt gcatgcacag tatgcaagta gttatggatt tataggaagt
    18061 ctacttgggt atcatccata tattatttct gtttggggta ctgatattta tgatttccct
    18121 aataatggtt ttatacaaaa acaaattata aagcataact ttagaaaagc agactatatc
    18181 ttttcaaata gtagagatat ggctaaagag gctaataaat atacagctaa acatgtagat
    18241 gtaacctttt ttggagtaga tatggatagg tttaagccta tggaagtaga aaaagaagac
    18301 gcttttgtaa taggaattat aaagagttta gaaaaaaaat atggaataga atatttaata
    18361 caagcattta agatgcttaa agatgaatat aaagataaga aaataattct taaaataggt
    18421 ggctctggaa gtcagatgga caacctaata aatttagcta aagaattggg tatagaaaat
    18481 gatgttcagt ttttaggaag aatatctcca gaaaatgtaa gcaagacttt taattctttt
    18541 gatgtaactg tatttccttc tttaagagag ggatttggag tggcagctat agaatcagaa
    18601 gcatgtgaag tacctgttat agttacaaat gtaggaggac atccagaatc tgtatgggaa
    18661 aatgaaactg gcttaattgt agaaccaaaa caaccagaag aaataaaaaa tgctataata
    18721 aaactaatgg aaaatgatga acttagactt aatatgggta agaaagggcg tcaatttgtt
    18781 agagaaaatt atgaggttaa tttaaacttt aatgatatag aaaaaattta tgattctata
    18841 tttgataaat ataaaaaata aaatgaaaaa atacagcaaa agatagatgt tgttggctat
    18901 gcttaggtgc gtagcttttg ctgtttaaag gagggcttct agttatgcga gaaagtatag
    18961 atttagagaa agaaagcttt tttaataggc tttttaaaaa atataaattt agacatttaa
    19021 cactattaat tctagatatt tgtagcgtac tagtagcgtt tcgaatgtct ttaagcttga
    19081 caggtaattt aaatgcattt accactaatg atataataat ttcagtgtgt atatatatag
    19141 tacttcatat agtatcattt agattgttta agtgctacaa cacattatgg agatatgcag
    19201 gagaagaaga aattatatct atttttgtgg caactttagc ttatttaatt ccgatttata
    19261 taataaataa attattaggg tttgattatc ctataatgtt ttatgtatta aatacaatat
    19321 ttattataat gtttacaagt ggcgcaagaa tagcctatag agctataaga atagtcatga
    19381 acaagacata ttctagagga aaggtttcaa atatccttat aattggtgca ggagatgcag
    19441 gagaaatggt tatacaggaa ctaaaaagaa atccagaact taagaaagta gcagtggcta
    19501 taattgatga tgataaaaat aaaattggaa gaataatcca taatgtgaaa attgtaggaa
    19561 caacttcaga tataaaagat gtggtagaaa agcacaatgt agatgagata atcttttcaa
    19621 tagcaaacat agagaaacgt agaaaaaaag agattattga tgtatgtaaa aacactaact
    19681 gtaaaataaa gacaatacca ggaatttacg aaattataga tggaaaagtt gatataaaac
    19741 agattagaga agtagagata gaagacttgt tgggtagaga gcctataaaa acaaatttaa
    19801 gagagataag taattacatt gagggaaaag taatcctaat aactggagga ggaggctcaa
    19861 ttggttcaga gctttgtaga cagattgcag gatttaatcc taaagagctt attatagttg
    19921 ataattatga aaataatgct tactcaatac aacaagaatt acttagaaaa tataaaaata
    19981 aattagattt aaagacagta atagcatcaa taagagaaga aaaaagaatg gatgaaatat
    20041 ttaataaata taaaccagaa gtggtatttc atgcagcagc acataaacat gttcctctta
    20101 tggaatcgag ccctggcgaa gctataaaga ataatatatt tggaacttta aacatagctg
    20161 gcttgtcttc aaaatataga gctaagaaat ttgtccttat atctacagat aaggctgtaa
    20221 accctactaa cataatggga gctactaaaa gagctgctga aatgattata cagactatga
    20281 atgctgaaag ccagactgaa tttgttgctg ttagatttgg aaatgtgctt ggtagtaatg
    20341 gtagtgtaat tccacttttt aagaagcaaa ttgaagatgg cggaccagtg acagttactc
    20401 atccagatat tattagatat tttatgacaa taccagaagc agtaggctta gtcatacaag
    20461 ctggggctat ggctaaaggt ggagaaatat ttgtacttga tatgggagaa cctgtaagaa
    20521 tattggattt agcaaaaaac ttaattaaat tcagtggatt tgagccagat gttgatataa
    20581 aaattgaatt ttctggtctt agaccaggag aaaagttata tgaagaacta cttatgtcag
    20641 aagaaggtct gttggataca gagcataaaa agatttttat tggtagacca atagatgttg
    20701 atagagaaaa aataacaaaa tacttaaaac ttttaagaga aattactaac aatgaagagg
    20761 ttgaaaaaat agatggtatt atgagggaat tagtgccaac ttatattaaa ccagaagatg
    20821 ctaatatcaa agaaattgca acaactagag aaaagtagaa tatatttcta atttgtaacc
    20881 agggggagca aaaagaaaca aatatatact aaaaagaaac aaaagattac aaaaagatta
    20941 caaaaagatt acaaaaaagg ttgcaattta ttttgatgta agatagaatg ttaattagga
    21001 attggaaacg aaggaacaaa atgttaaatt ttcgaaagga ttaggtattt gagattatga
    21061 tgaatattaa aaataaaaaa catatattga aaaaatttat agctatggtg ttaatagcag
    21121 gagttgtcac agtagaagca ggagcaataa cggctagtgc agcagagcca actaattcac
    21181 ctatgagtgc aacagtagac cagtgtgatt ttttaaatgt aagaagtgga gctagtgcaa
    21241 atgatgcagt agtaggaaag ataaacacag gagacaaagt tgaagtttta gaattacatt
    21301 caaatggatg gattaaaata aaaagtgttg acaatgttac aggatgggta aatggagatt
    21361 atttaactat tcaaggtgga aatgtagatg caaaggtaca aaatgtttta aacttagcat
    21421 ttaagcaaca aggtaagcca tatagatggg gagcaactgg accaaatgct tttgattgtt
    21481 ctgggttcac ttcttatgtc tataaaaatg gagcaggagt taatttacca agagtatcaa
    21541 gatcacaagc aacagtagga aagaaagtat caagagcaga attaaaacca ggagatttag
    21601 ttttctttgg ttcaggtggt tcaataaatc acgttggatt gtatgtagga gattctaaat
    21661 tcatacattc accacaaaca ggagatgtag taaaagttac tagcatggct ccaggaacta
    21721 attatgcaag aagacttata actgctacac gtgttttaca ataataatag atattgattt
    21781 acataggatt gaatattaac attaaatata taattacatt taatgtttta catagagatt
    21841 taagagttta gtaatattaa aatagtgatg aacgttataa aaacagcaaa gaagataaat
    21901 ttctttgctg ttttttttat aataaattat ttcatattat aatcaaatat caaatataaa
    21961 ttttaactat attattcaat atttgacaga taatatgaat tttagatata cttaataaga
    22021 agtatattgt agaaaaaata aatttaaaaa attaaggggg atgaaatgaa aaaaataagt
    22081 atattagtat tatcattgat aatgacactt actatgtgta gtgtaagttc atttgctgat
    22141 tcatcaaatg ataaagaaat gagagctgct tggatatcta cagtttataa tttagactgg
    22201 cctaagacta agaataatga agccaagcaa aaaaaggaat acacagattt attggacaaa
    22261 ttaaaaagtg taggaataaa tacagcagtg gttcaagtaa gaccaaaatc agatgcttta
    22321 tataaatcaa atataaaccc atggtctgaa tatcttaccg gtacacaagg taaagaccct
    22381 ggatatgacc cattaccatt tttaatagaa gaagcacata aaagaggaat ggaatttcat
    22441 gcatggttta atccatatag aataactatg gcagatgaga gcatagataa attgccagca
    22501 aaccatccag caaagaaaaa tccaagctgg gtagttaaac atggaaataa gtattactac
    22561 gacccaggtt taccagaagt tagaaagtac atagtggata gtatagcaga agtagttcaa
    22621 aattacgata tagatggagt tcattttgat gattacttct atccaggagt aagtttcaat
    22681 gatactgcaa cataccaaaa atatggaaaa ggacaaaata aggatgattg gagaagagaa
    22741 aatgtaaata ctctacttag agatgtaaaa gcgtctataa agagtataaa gcctaatgtt
    22801 gtatttggtg taagcccagc aggtatatgg agaaataaga gtagtgaccc aacaggttca
    22861 gatacatcag gtaatgaaag ttatgtaggt acatatgcag atacaagagc atggataaaa
    22921 caaggattga ttgactatgt agttccacaa ctttactggc caattggtct taaagcagca
    22981 gattattcta aattagtggc atggtgggct aatgaagtaa aaggaacaaa tgtagactta
    23041 tacataggac aaggtatata taagcaaggt caatcgagtt atggtggaca aaatatagca
    23101 aaagaaatag tacaacaagt aacattaaat agaaagtata gtgaaataaa aggtagtatg
    23161 tatttctcag ctaaagatat agcaaatagt acttctatac aaaaggattt aaagagttta
    23221 tattctagta gtgaagaacc agttactcca ccatctaatg ttaaagtgga gaaattaaga
    23281 ggcgacgaaa gatatgacac agcagtagca ataagtaaaa aaggttgggc tacaaattca
    23341 gatacagtag tattagtaaa tgggtactct atagttgatg gtataacatc aacaccactt
    23401 gctacatcaa atgatgctcc tatactattg gtaaataagg ataatatacc tacatccact
    23461 aagaatgagt taaaaagact taatccaagt aaagttattt taattggagg aaataactct
    23521 attggagata aagttgagag tgagataaaa gatacattgt caaatgtatc aataaataga
    23581 gttggtggtt cagatagata tagtacatct ttaatgatag caaaagaatt agtaaaaact
    23641 aatccagtag aaaaactata tataacaagt ggtacaggtg aagcagattc tctttctata
    23701 gcttcaaaag caggagaaga aaagcaacca atagtattag tatcaaaaga taatgtaagt
    23761 gatgaagttt acaattggat atcagattta aaagtaaaag atgcttattt tataggtggt
    23821 aatctaagta tatctgattc agtaataaat aagctggata aggtcattac aaatgatgta
    23881 tctaaaaata gaatagctgg agaaaataga gaagaaacaa atggaaaagt aatacaaaaa
    23941 ttctatccaa atgctgaata ttcatcaatg tttgtaagta aaagtaatca attggtagat
    24001 gcattaacat caggtccttt agcggctaaa ttaaaatcac cagtagttat gcttggaaat
    24061 agtgtaacat ctgctcagaa aactgcttta gagcctaaga aaactactct agtatacgaa
    24121 gctggagatg gtataaatca aaacacatta aacactttct taaacttagt taagtaataa
    24181 aaaagttaat ttaaaataca gagtatttta caaatataga ttaaaatgaa aattatcatg
    24241 ataaattaga aaataaaaaa gaactatatg cattttgtaa tcaagtgtac acagcaactt
    24301 gaaaataatt atgcgatata gttctttttt agtaattaat cttatacttt ttaataaact
    24361 ttatgttgaa ttttttattg tttaaactct atgtcattaa atataaaatc gtgtaatatg
    24421 tctaaagtat ctgggtcaaa tctaagaacc catccagctt ttccatatat accacctgta
    24481 ctatgaattt catcatcaat aggaaattca aattgcttaa tatttaagtc acccattttt
    24541 aaaacttgag ctcctaaaga aagtattgca ttaggcttca tgttagtttt aacatatgga
    24601 agaactgcat ctaataaacc tggatattta gtaacaggta aagtttccgt tttcttgatt
    24661 atagcttgta taatctgtct ctgtctgcca tctctagcaa aggctgtatc gttgtgtctg
    24721 atacgtgcaa aagatagtgc ctgatatcca tttagagtct gctttccaga gtttctaatg
    24781 tattgtatgc tacctttatc atcactttta ctccatttat aagtttcagg aataaattta
    24841 tttagttctc gtatttctcc tttttcaaca gtaacctcaa cgccaccaat agcatcaatt
    24901 atatacataa atgattcgaa attaacacaa gcataatttt gaatatcaat attaaaattc
    24961 tcttcaattg tttgtattaa taaatcagct tgtccataag cataagcatg agtaagtttt
    25021 tgtttaccat gaccagggat gtctacatag ctatcacgag ctaatgatgt aagtttgata
    25081 tcattgtgtt tgttatcaat agtaagtatc atcatagcat ctgaccttga agaatcttca
    25141 tttggtctag catctgttcc cataagtagt atgttaatta tcccatcttc atttttatgg
    25201 tcattgttat ccaataaatc actacttatg ctcgagtcat gaatagcaga taatttataa
    25261 taaaaatatc catagacact tatagggaat attactacca agaaagccag tagtataaca
    25321 aatttcttta attttgacaa aagtacccct tctttcttct ttttcctgta tattttttaa
    25381 tagcatacac ttaattatat taaagtattg agatatattc aatacttgtt tcagttacaa
    25441 aaaaaagaca atgatataat ttataagaaa atttatcgac ctatatatat agttaaaagt
    25501 atatataata tattttttaa aagtaattta tattttaaaa taaaaacaca ccccataaat
    25561 acaaagtaat ttgcatttaa gaggtatgta tttatcatca aattattggt ttgttttgga
    25621 atttctaatc ttcaaccata atatctttaa atatgaaatc atgcattgca tctagttcat
    25681 attcctcaaa aggtattaca tagcctgcat tacctatttt tctaccattt tcagtagaaa
    25741 gaggaaactc catagatttc aaatttaaat ttcctatact taaaagttct tttcctaaag
    25801 atattatttc attaggattc atattagttt ttacatacgg aagtattgtg ttaactagat
    25861 taggatattt agtgactggt aaatccttaa caccatttat taaactctgt ataacacttc
    25921 tttgtcttct atctctttca tctgtactat cattttttct tatacgagaa aatgcaagtg
    25981 tctgatatcc atttaatttt tgctcaccag aatttcttat atatttaaga gaacctttat
    26041 tgtcattttt attccattta taagtttcag gaataaattt atttaattct cttatttcac
    26101 tcttatcaac agtaacagta actccaccta aagcatcaac tatatccata aaagagaaaa
    26161 agtcaactac ggcgtagttt tgtatatcaa gttggaagtt ttcttctata gtttctatta
    26221 ataagttagc ttgtccatat acgtaggcat gtgttaattt ttgttctcca tgtcctggta
    26281 tattaacata agtatctcta tttaatgaag ttagcttaag acttttattt ttattatcaa
    26341 tagtaagtat catcatggca tcagaacgag aaacttcttc tcctggtctt gcatctgtac
    26401 ctaacaataa tatgtttgtg atattttctt cgtttttata gtcattacta ctaagcgcct
    26461 ctgtatttat actatcatct tgtatagttt ttaatttagt aaaaacatat ccatatatac
    26521 taacaggaaa tgctataact aaaagggcta gaaatataac gaactttttg agtcctgaca
    26581 ataatatccc ctactttcta aattttttaa ttacacatag ttaattatat taaaaatttg
    26641 ttacataagc aataaaaaac acaataaatt agcataagtt tgtcataata taattatttt
    26701 tatagcattt tatagaagaa agtgtgtagt tattattgat tttattggaa tataattgta
    26761 tgaagactta aatttttata aactaatgtg tatattgaaa aaaatatttt cctgaatgta
    26821 gttatagcat cttatgaaag gtgcaaattg taatttaaaa tttttagtgt ataataagaa
    26881 ttgaaaattc aaaccgataa aaattaataa aaaataatta taaattaata atttggggga
    26941 ggaaatgtat gataaaatta atagcaacag atttagatgg aactttgtta gatgaaaaga
    27001 gcgaaataaa tccagagttt tataaagtat ttaaaaaatt aagagagaga gggataatgt
    27061 tttctgctgc tagtggcagg cagtatcaaa atctgataaa aaaatttgaa gatataaaag
    27121 atgatatgat gtttatatca gaaaatggaa cactagtagt atataaagga aaagaaatat
    27181 tatcaaatcc tttaaataaa gaattagtaa atgaaatcat agagacaaca agaagtataa
    27241 aagggaaaaa aattgtaatg agtgggaaaa aatacgctta tatagaaagc aaagatgaag
    27301 cgtttataca agaggttagt acttattatg caaagtttaa aattgtagaa gatttgacga
    27361 aagtagaggg agacatattg aagatagctg tgtttgactt caaaggtgca gaacataata
    27421 ataatatcta ctttgaaaag ttttctgata gagctcaagt atgtatttct ggagtggagt
    27481 ggcttgattt aactgcaaaa ggtgcaaata aagggagtgc cataaaaaaa gtacaaaaaa
    27541 tgttagatat aaaatatgaa gaaactatgg tatttggtga ccagttaaat gatgtggaaa
    27601 tgatgaaaag tgcctatcat agttatgcca tggaaaatgc aaatgaacat ttgaaacaaa
    27661 ttgctagatt tagagcaaaa agaaatactg aaaatggcgt tgtagataag ataaaagagg
    27721 ttataaaaat tggatagtca tatgtataga tgaaaaagat tattttgaag aaatcaaaaa
    27781 aatatcaatg taattttgat aaataagttt atttatgcga aaattacatt gatatttaat
    27841 aaacatcaat aatagatatt tattttttta tgatattcag tattttgttt tctatttgag
    27901 ttgcattttc agcagaaatt aaataaacat acctacctgc cttctcaatt atagtattat
    27961 ttgctatttc agaattgatt ttttctccat gtccttctcc aaaaggtgct tgtatcatat
    28021 cttttttata attttctaga gttttataga ttttatctac ctcgtcagtt tttataacga
    28081 taatatcttc tagagataat ttttcagaag aattaattac aaaaccttga attatgtctt
    28141 cctctacatc attaaaatag ttaaaatcct ttgcatcaaa gatttttgat tcctttataa
    28201 gtaaatcaga agattttaat gcttttttta tttttgatgt agaaacgttt ttgtaatcac
    28261 cacttgaaga acaactaacc attcctaatg ataagattat cgaaaaaaac aatattaaaa
    28321 tttttttcat gataaacctc caagtttttt aaactctgtc ttaaattagt ttactacata
    28381 attatataaa aataaatgta tttaatgtta cagttttgat taataatgta atattttgat
    28441 aataatacct attgagaggt gattagaaat gagaatacca aaacatgtag gaattatacc
    28501 ggatggaaat agaaggtggg caagtcaaaa tggtatgaca aaagataaag gatatgaaag
    28561 tggaatagac cctggactag agtcttatag attatgtaga gatttaggct gtgaagaggt
    28621 gactttttat ggatttacaa ctgataatac aagacgtcca tcagtgcaga caaaagcttt
    28681 tacaaaagca tgtattgatg ctgcaaatat attaatagat gaaggtgctg ctttattagt
    28741 tgtaggaaat acaaaatcgc caatgtttcc agaagaatta ttaccatata ctaatagaat
    28801 taaagccaaa gaaggtcaaa taaaagcaaa tcttctggta aattatggtt ggtattggga
    28861 cttaaataat atatcaggag tagaaaatgt aaataaaaat aatatacagg attacataca
    28921 gtcatttgat gtatccagac tagacttgat aatcagatgg ggtggaagaa ggagattaag
    28981 tggtttcctt cctgtacaat caatttatgc agatttttat gttatagata attattggcc
    29041 agattttaag agtgacgata taaaggacgc atttagttgg tatgatacac aagatgtcac
    29101 tttaggtgga taattaaaaa tattctgatt taaggttgta gagtgtttta aattattgaa
    29161 aaaaaaactt cttgatggta aaataacact aataatatgt aaaagtgtaa aaatttatac
    29221 caagaagggt gaagaaatgt caaaaggcaa taataacaat aattcaagaa acaaatctaa
    29281 aaagaccagt catctgaata gaaaaaagcg aaaattaaat aagaaaaagt tagcagtgtt
    29341 gatttgcttt acagttttat ttttatttat tgcatttaag gctactcaag gtgtagtagc
    29401 tttggtaaaa agtatggata aaagtaataa aactagtcaa caacaaaatg ttaactcaga
    29461 acaatttgac cttggtaatg aagaggaaaa taaaaagaaa aaatatactg tatttataga
    29521 cccaggtcat ggaggcaatg ataaaggaac tgaaagcaag accagtaata gatatgaaaa
    29581 agacctaaat ctacaaattg caaaaaaatt agcaaataaa ttatctaaac aaaaggatat
    29641 tcaagtagta gtatccagaa ctgatgatac atatatatca ttaaaggata gagctatctt
    29701 agcaaataat agttctgctg atgtgcttgt ttctattcat ttaaatgcag agaaaaatgg
    29761 taatacagca acaggtatag aaacttggta taggaataaa gctacagatg gttcaaaaga
    29821 acttgcacag acagtacaaa gtactatagt atcctatgtt aaagttagag ataggggaat
    29881 agttgaaaat aactttgaag tacttagaga atcaaatatg cctgctatat taatagagtg
    29941 tggtttttta acaacacctt cagaggaaca aaaaataata aatgaaaaat atcaagacca
    30001 acttgcggaa ggaattgttc aaggtgtact ttcataccta gattctaaag ggaataagta
    30061 aattaacttt actttaatgt gaggataaat ttaaaagttt aactgtgtaa attgtattaa
    30121 ctttatttcg taatgttgga aatattgttt gaatttagaa actat
//
LOCUS       DAEPID010000047        28511 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.047, whole genome shotgun sequence.
ACCESSION   DAEPID010000047 DAEPID010000000
VERSION     DAEPID010000047.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 28511)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 28511)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..28511
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.047"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            complement(20..799)
                     /locus_tag="KR257_002364"
     CDS             complement(20..799)
                     /locus_tag="KR257_002364"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898073.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0031047.1"
                     /translation="MKVNENNINNIDEELDELSRKVYLESPDFWISISDKIIDKVFDE
                     MLLFFAVKYNYFNIVCFAIENNYLDLNMPSKNKKYTNIMEHLLDTSKQNEDKKIYNYL
                     LSLNKGNNLDERPILDELNCNISSDTFEKKDIYLPKYLCPSCNSNIFDTGYKVSNDIT
                     YKFSSKEAEPIEMCSEVSSIRCCNCDELLEDITLDKLYNLCKIQNCNNCGSNLTKVGI
                     IAKKKMNFDENTEKFKDVSTSYCCGNCDSEINLSQREHFKI"
     gene            1123..1668
                     /locus_tag="KR257_002365"
     CDS             1123..1668
                     /locus_tag="KR257_002365"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891255.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="biotin transporter BioY"
                     /protein_id="HBH0031048.1"
                     /translation="MKNTKVNIQDLTKMSICVALLCISSYIYIPLPFTPAGVTAQTIM
                     INLIALILTPRQAFSTVGVYIMIGLIGIPVFGGGTSGIGKLLSPTGGFYFGFLFAALI
                     ISLLKGRNNDIKRYILITIFVGMPIIYFMGTVFMCYFNQMTVEAALFAAVVPFLIGDT
                     IKSVIASFLGTKLNNVLRRNL"
     gene            1700..2836
                     /locus_tag="KR257_002366"
     CDS             1700..2836
                     /locus_tag="KR257_002366"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891252.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="thiolase family protein"
                     /protein_id="HBH0031049.1"
                     /translation="MKEVFILGGLRSHIGLKNGIFQFVQPELLGASVLKDLIKKYEID
                     KIDEIICGNAVGTGGNIARLMTLTAGVSNEVPAFTVDMQCASAMMSIDIAFSKVKSGQ
                     CDLIIAGGFESSSLQPMRTYHKNDKRYNTNNPNYTVAQFSPDDNSQNSMLEGAERVAE
                     LYQIEKADLDFWVKESHKRAKEAREEKILEDIISPINNSTYDEGIRDKMSQRLLDRMP
                     SILGKETITNAANSCLINDGASFIIICSKKYLEHVKKKPKAKIINTCTIGTDATLSPT
                     SAIQAMDKLLEIESLNYLDVSAVEFNEAFAVIDVLFQRKYPELIDRYNIFGGALAYGH
                     PYGASGAIIALHLLKALEKTKGRYGICSIAAAGGLGSALLLERV"
     gene            2840..4231
                     /locus_tag="KR257_002367"
     CDS             2840..4231
                     /locus_tag="KR257_002367"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422637.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AMP-binding protein"
                     /protein_id="HBH0031050.1"
                     /translation="MNYYELLRIKKERHKNKNFLIIDGEKYTYENILSYSEELGKQIS
                     LGENIPILIYSKNIMFQLISFFAINYSKNIPIICHYNLSKKVLDDILLKNNISIIISD
                     ESMDVIDLYDDNNNEVAKKVNFSIFNPKFNIYMYQYKNLINYLDKSICMGALSSGSTS
                     VPKVLYRTYESWAGFFPIQNGIFNISGESILFVNGTLSFTGNLNSIMSVLYEGGSIVI
                     SSGLNCKSWIRIIKQYNVTNIYLIPTKLQLLVKHLKEPVLKVVSIFTGSQLLFEDTAR
                     NLKKYMPKSEIILYYGASELNYITYLCYDELIEKPLSVGRPFPGIDIYIREGKIFVNT
                     EYAVYNATKPYSVNDIGYYDNDGYLIFEGRSDDILNIGGFKVSSTKIENEVKKIPQIE
                     DAIVLPYSDTIRGNQIVLFVITIDKITKKDLLIKMKDNLMKNEIPKKIIFLNSFPYTS
                     SEKIDRLALLKML"
     gene            4307..5182
                     /gene="dpsA"
                     /locus_tag="KR257_002368"
     CDS             4307..5182
                     /gene="dpsA"
                     /locus_tag="KR257_002368"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898070.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dipicolinate synthase subunit DpsA"
                     /protein_id="HBH0031051.1"
                     /translation="MSNQYDITVIGGDLRQVYMVKKLINKGYSVVTYGISNEIINGIV
                     GKSTSLAEALSKSSIILCPIPFTKNQVNIENTDDCLDATIDNLLINLSPNQILFGGNI
                     PTKVCKFCEQHSIQIYDFMKMNDVAILNAVATAEGAIAEAIKRSIINIHQSNCLVLGY
                     GRCAQILAKKLYALDANVCVGARNNDARSTANAFGYSSISLSQLDEKLLQFDYIFNTI
                     PECILTKERLEKVSQEVTIIDIASSPGGVDYSVVKEAGINATLCLGLPGKYSPKTSGE
                     ILVNAIENIINERRD"
     gene            5185..5775
                     /locus_tag="KR257_002369"
     CDS             5185..5775
                     /locus_tag="KR257_002369"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429956.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dipicolinate synthase subunit B"
                     /protein_id="HBH0031052.1"
                     /translation="MRLEGLTIGVGFTGSFCTYDKIFIELENLVKEGANVHTIFSDVS
                     QNIDCRFGNSEEFMKKAYELTGNKPIVTIEEAEPFGPKGIADIIIIAPCTGNTAAKLA
                     NGITDSPVLMAAKGHLRNDKPLVISISTNDALSFNFKNIGILLNSKNIYFVPFGQDNC
                     KAKPNSMIAHTELIIPTIELALENKQLQPVIKSPHQ"
     gene            complement(5982..6182)
                     /locus_tag="KR257_002370"
     CDS             complement(5982..6182)
                     /locus_tag="KR257_002370"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003431711.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0031053.1"
                     /translation="MEKLKTISVFSLIISVILTIGGIGIVTYYVDNLFIRGLSVFVLI
                     MSSSFVSTTVRLIFEESKRYKF"
     gene            6686..9340
                     /gene="adhE"
                     /locus_tag="KR257_002371"
                     /gene_synonym="adhC"
     CDS             6686..9340
                     /gene="adhE"
                     /locus_tag="KR257_002371"
                     /gene_synonym="adhC"
                     /EC_number="1.1.1.1"
                     /EC_number="1.2.1.10"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422645.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional acetaldehyde-CoA/alcohol
                     dehydrogenase"
                     /protein_id="HBH0031054.1"
                     /translation="MAHKEQVIIENKKENEVMSVGLDTVNNVESLVKKLAKIREAQKI
                     FATYSQEQVDKIFLAASLAANKQRVPLAIMAQKETGMGIAEDKVIKNHYASEYIYNAY
                     KETKTCGVIEKDEAFGMTKIAEPIGVIAAVVPTTNPTSTAIFKALLALKTRNGIIFSP
                     HPRAKNSTIEAAKVVLEAAVLAGAPEGIIGWIDEPSLELTTTVMKEVDLTLATGGPGM
                     VKSAYSSGKPAIGVGAGNTPAIIDDSADIKTAVNSILVSKTFDNGMICASEQSVIVLE
                     NIYNEVKKEFKERGAYLLDKDETEKIRNIILVNGGLNSKIVGQTACTIAKLAGFEVPV
                     DTKVLIGEVESVEIEEAFAHEKLSPVLAMYKASDFDDAVRKAEKLVEDGGFGHTSSLY
                     IDDVNQREKLDKFTSAMKTCRILINTPSSQGGIGDLYNFKLAPSLTLGCGSWGGNSVS
                     ENVGVKHLLNIKTVAERRENMLWFRAPEKVYFKKGCLGVALKELKDVMNKKRAFIVTD
                     TFLYNNGYTKAVTDLLDEMNIKYTTFFEVEPDPTLECAKIGAKAMREFNPDVIISIGG
                     GSAMDAGKIMWTLYEHPDVDFQDLAMRFMDIRKRVYTFPKMGEKANFVAIPTSAGTGS
                     EVTPFAVITDQDTGVKYPLADYELMPNMAIVDSDMMMNMPKSLTSASGIDALTHALEA
                     YVSMLATDYTNGLALQAIKSIFEYLPRAYDNGAKDPEAREKMANASTMAGMAFANAFL
                     GVCHSMAHKLGAFHHVPHGVANALLITEVMKFNSSDAPKKMGAFSQYKYPEALKRYAE
                     IASFLGLKGNSDEEKFQSLLVAIEDLKLKVGIPKSIKEFGVEESKFMDSIDEMVIQAF
                     DDQCTGANPRYPLMNEIKDMYLNSYYGR"
     gene            9616..11835
                     /locus_tag="KR257_002372"
     CDS             9616..11835
                     /locus_tag="KR257_002372"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003439757.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="EAL domain-containing protein"
                     /protein_id="HBH0031055.1"
                     /translation="MTGRNKSFTLITILFLTSLFLTMGYIYIEDTKHLLMSEAKIHIK
                     EVAVQGSQLAQRQIEKDLDVLNIFSNYYASNPDIPNEEKMKNLLDEMENQKFYTMAIV
                     DINGNAENTKGDKFSVKDREFFKNSIKGKKYVSSPYVDEVNKSIKKIAISVPLLNNDK
                     VVGVLYCTYNINTLMKLINISFYENNSISYVVKNDGTIILHPQGDSLSKNIYKLLEQD
                     NDIQEVNRLKKELQENKTGATVLNMLEERRYLGYATMDNGNSENNYIKDWNLIFSIPE
                     TVVFSNSKQIINRAVYAVLSIVLIFVAIIFYIIYIKKSNEKEILSLAYEDKVTYIGNQ
                     NKFYRECSKYLLDKPSLNYIIVYFDINNFKMINDTFGYEFGDNLLITIAKALKEELTE
                     GEVYARLSSDYFAIFCDYKNGRNKIIRKLDNIRSNIESNLSIVFEISLCVGIYFVEEG
                     EVDIQKAVNKANMARSVAKGKNINYAIYNEDVRNKLSEESMILDDIKIALVKNQFEVY
                     YQPKFSLVTGEMIGSEALIRWNHPEHGFISPAVFIPIAEKSKLILKIGRFVFERVCND
                     LYEWKKQGKKIVPVSVNLSRVELYQPDIVKFINKTIKMYNLSSDFIEIEITETVAINE
                     LNILKNVLNELRTYGFSISMDDFGTGYSSISCLRDMPIDILKLDKSFLGGIEHDERSR
                     NIAKSIVSLAKSLDLVVIIEGVESKEQAELMKQFGCDLVQGFYFARPMPAKNFLDLL"
     gene            12089..12751
                     /locus_tag="KR257_002373"
     CDS             12089..12751
                     /locus_tag="KR257_002373"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003439746.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA-binding protein"
                     /protein_id="HBH0031056.1"
                     /translation="MIDISIDDKLKERWPNAKLGCIQAKVAVNKSSEKLINEINEFCD
                     TINQSLKVEDITKLDKIKDARNAYKELGKNPSRYRTSSEALVRRIIQGKGLYTINNIV
                     EINNLISIKSLYPVGTYNVSKLHSPVCFTVGDEGEQYKGIGKELINIENLPILSDSVG
                     KFGSPTSDSERAMITEDANEILICIFSFSQESDIEEYFGYAKELLKEYADGKDIETKI
                     IK"
     gene            13122..14531
                     /locus_tag="KR257_002374"
     CDS             13122..14531
                     /locus_tag="KR257_002374"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009906176.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="L,D-transpeptidase/peptidoglycan binding
                     protein"
                     /protein_id="HBH0031057.1"
                     /translation="MIDGKEVKQESGQKNLKFKIAIVVGVLFVAYIGMAIFFRNHFYF
                     GTTINGVKASGKTVEQVNDLLASSTNSYTLNLEERNNKKEQIKAKDIDLKFTPDDKVQ
                     KIKDSQSAIGWIGGIFKSKEYNNMITLSYNKDLLEKRFNALSCFDSKNVVEPKSAYPK
                     YDSTKNAYVIVPEVLGNKVKKDDFYKLVQNSINSGNTSISLDESKVYEAPNNTKDSEK
                     LKQAIKTLDKYVGVVVTYDFSDRKETLDGSEINKWLKVDSEKNYDITFDNDAMVEYTR
                     GLSKKYSTFGDSRPFKTATGKDITISGGIYGWLIDKKKEAEALVDVVKAGKNVTREPI
                     YIQKAVSRNKDDIGNTYVEISLSGQHMWFFKNGEMLVSTDVVTGDLARGFATPSGIYP
                     LNYKARNVSLTGQGYSSPVSYWLPFNGNIGIHDATWRNSFGGSIYKSSGSHGCVNTPF
                     SKAKKIYENIEPGTPIILY"
     gene            14646..14921
                     /locus_tag="KR257_002375"
     CDS             14646..14921
                     /locus_tag="KR257_002375"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422652.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Nif11-like leader peptide family natural product
                     precursor"
                     /protein_id="HBH0031058.1"
                     /translation="MNEKLTKILEEAKNDDEFRKELIKTREQRDVMDSFCKVVTSRGY
                     DMTVGELFSMGEEYTSNLLKSVNGGAAYPIEDWSDWYEDFFIMLSNI"
     gene            15551..15862
                     /locus_tag="KR257_002376"
     CDS             15551..15862
                     /locus_tag="KR257_002376"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426769.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0031059.1"
                     /translation="MAFEIIKSIVEAEQTADSIKVKAVTDAESIRADAVNKCESIFAD
                     VKKQAKLMEETLIEKAVTDSRAEVDKILANAKSECLKIEKTAEERKSKAIEAVIGKVV
                     R"
     gene            15864..17789
                     /locus_tag="KR257_002377"
     CDS             15864..17789
                     /locus_tag="KR257_002377"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426767.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="V-type ATP synthase subunit I"
                     /protein_id="HBH0031060.1"
                     /translation="MAIVNMNKISIVGLEAQKSQILKLLMNRGFVQIDDSAFLTEEEE
                     LKNYLVKDSEESEVIMLEQKMSHVNQAINIVSSLVKQKKSLLAPKREFNKIDSEKEGQ
                     VYAEALELNNLHKEIGTIRSNINLLNNNKSMLEPWVNFDIPIENMETKYTKTILGTVP
                     ISANIDALRVKLEDEIPESVIGIVNSDKLMNYVYLITLKETFDDVLEVLKEFNFSVVS
                     LPNEEGTPLQAIKKYNEMIIRQENVSKDKTEEIKRHADSIHMLENLYDFYTIERDQKK
                     IIERLVKTKTTFCLNGWLPSKRADELIKEITEKFDCCVQTEEGSKEEGFPILLENNKL
                     VTPFESVTNMYSYPSTKDIDPNTILTFFFVIFFGMMLSDAAYGLIIAVVCGFVVYKLK
                     IQKGEGNLIKLIGICGVSTTVWGLIFGGILGDLIPIKALINPLEDVMTLMGMSLLFGI
                     IHIYVGLGIKAYTLIRSGKVIDAIFDIGFWYLCITGVCLLIIPFVAGDIGVFSEVGKY
                     LAIIGAIGLVLTQGRSFKGIPVKLFKGFSSLYGITSYFADILSYTRIMALCLTTGVIA
                     QVINLLGAIAGPILAVVIGVVGHTINLLINALGAYVHTSRLQYVEFFNKFYEGGGVPF
                     VPFKYKTKYTSINKKEM"
     gene            17792..18283
                     /locus_tag="KR257_002378"
     CDS             17792..18283
                     /locus_tag="KR257_002378"
                     /EC_number="7.1.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422657.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="V-type ATP synthase subunit K"
                     /protein_id="HBH0031061.1"
                     /translation="MEFLNALGNGQFLAISGAAIAALFAGMGSAKGTSIAGQAAAGVV
                     TEDPSKFGQLLVLQLLPGTQGLYGFIIAFLILSKAGIIGGDAIPTSAQGLQLLMAGLP
                     IGLVGLVSGIAQGKAAAAGVGIVAKRPEELGKAITFAAIVETYALLGLLVSFLAYNGI
                     AIG"
     gene            18335..18898
                     /locus_tag="KR257_002379"
     CDS             18335..18898
                     /locus_tag="KR257_002379"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422659.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="V-type ATP synthase subunit E"
                     /protein_id="HBH0031062.1"
                     /translation="MGNEQKMIDRIIADAKQEAQEILDKAKSEADLKVNSANEKAEKE
                     MASYTKLAEAEAEKAASKEISGAYMEAKKQILSKKQEILEEVILEAKNKLLNLKDNEY
                     EEIILNMIEKSNCTDDSEIVLSKKDKKTLKDVLSKKGIKVSDETRDITGGFIVKKGDI
                     EYNYSFEAIIAVEHEYIEQIAAEILFN"
     gene            18913..19890
                     /locus_tag="KR257_002380"
     CDS             18913..19890
                     /locus_tag="KR257_002380"
                     /EC_number="7.1.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898066.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="V-type ATP synthase subunit C"
                     /protein_id="HBH0031063.1"
                     /translation="MAEEKTYPYAVARIRVLEKQLLNRQMFIQMAEAKSPEDSLRIIA
                     EAGYADTSNNNIHNFENILTQELSKTYEILKSLAPEEKFVDVFLYKNDYHNLKVLIKE
                     EISGVDGEKYLIDGGTIPLIKLRESLANRSFSDLPKIMSSAILEAFDVYNKTQNGQMV
                     DIVLDKATFTSMKETAKESQNKFVIDYVMKVCDLTNLKSFIRVKNMKKDFDMFMNVFV
                     SGGSLDKEKFLEAFSSDTPASCFKSTSYSDVCKNGMDSGFTVFEKLCDDYLMEYVRGA
                     KFKPLTLEPLIAYLYAKESEIKTIRIILTSKLNNIDADTIKERLRDAYV"
     gene            19877..20200
                     /locus_tag="KR257_002381"
     CDS             19877..20200
                     /locus_tag="KR257_002381"
                     /EC_number="7.1.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422665.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="V-type ATP synthase subunit F"
                     /protein_id="HBH0031064.1"
                     /translation="MLMYKVGVVGDKDSIMGFLALGIDIFPAYDSDEIKKSIHKLVED
                     EYAIIYITEQASLLAKESIAKYKDYQLPAIIVIPGIGGSMGLGMNEVRESSKRAIGAD
                     ILFKE"
     gene            20317..22095
                     /locus_tag="KR257_002382"
     CDS             20317..22095
                     /locus_tag="KR257_002382"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426762.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="V-type ATP synthase subunit A"
                     /protein_id="HBH0031065.1"
                     /translation="MKTGTIVKVSGPLVVAEGMRDANMFDVVRVSDKHLIGEIIEMHG
                     DKASIQVYEETSGLGPGEEVVSLGMPMSVELGPGLISTIYDGIQRPLEKMYDISGTNI
                     TKGVEVSSLDRTTKWEFKPKKSVGDKVVAGDIIGGVQETAVVECKIMVPYGVKGTIKE
                     IYSGEFTVEDTVCVITDEKGNDIPVTMMQKWPVRKERPYREKKTPDSLLVTGQRVIDT
                     FFPITKGGVAAIPGPFGSGKTVTQHQLAKWADADIVVYIGCGERGNEMTDVLLEFPEL
                     KDPRTGESLMQRTVLIANTSDMPVAAREASIYTGITIAEYFRDMGYSVALMADSTSRW
                     AEALREMSGRLEEMPGEEGYPAYLGSRLAQFYERAGKVNCLGMDEREGTLTAIGAVSP
                     PGGDTSEPVSQATLRIVKVFWGLDASLAYKRHFPAINWLTSYSLYQEKVDVWADKNVN
                     DNFSAQRAQAMKLLQVESELQEIVQLVGVDSLSDGDRLILEVTRSIREDFLHQNSFHE
                     VDTYTSLHKQYRMMGLILKFYKSAQDAIKQNVTINDIIKLSVLEKIGRAKYVEEGDID
                     AAYDSIEDEIDNELADLIKKRGAEEL"
     gene            22092..23465
                     /locus_tag="KR257_002383"
     CDS             22092..23465
                     /locus_tag="KR257_002383"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422669.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="V-type ATP synthase subunit B"
                     /protein_id="HBH0031066.1"
                     /translation="MIKEYKSIQEVAGPLMLINGVEGVKFDELGEIELSNGEIRRCKV
                     LEVNGDTALVQLFESSTGINLAESKVRFLGKSLDFGVSPDILGRVFSGMGRPIDGGPE
                     IIPDKRLDINGAPINPAARDYPAEFIQTGVSAIDGLNTLVRGQKLPIFSGSGLPHANL
                     AVQIARQAKVRGTDSKFAVVFAAVGITFEDAEFFISDFKATGAIDRSVVFVNLANDPA
                     VERVSTPRMALTAAEYLAFEQDMHVLVIITDITNYAEALREVSAAKKEVPGRRGYPGY
                     LYTDLATMYERAGKMKGHEGSITMIPILTMPEDDKTHPIPDLTGYITEGQIILSRELY
                     KKDIQPPIDVLPSLSRLKDKGIGKGKTREDHADTMNQLFAAYSRGKDAKELMAILGES
                     ALSEIDLMYAKFADEFEKEYVSQGFRTDRTIEQTLEIGWKLLSMLPKSELKRIRDEYF
                     EKYMPKE"
     gene            23471..24139
                     /locus_tag="KR257_002384"
     CDS             23471..24139
                     /locus_tag="KR257_002384"
                     /EC_number="7.1.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891221.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="V-type ATP synthase subunit D"
                     /protein_id="HBH0031067.1"
                     /translation="MARLNINPTRMEMTRLKKLLKTATRGHKLLKDKLDELMKQFLEI
                     VRENKRLREEAENALDTAYKNFIIARAVMSQEYLGSALMMPKQSVSVDVSTRNIMSVD
                     VPVFDFKTENNQSDIYPYGLAFTSGELDSVMEAFSDAMQPLLRLAESEKSAQLLAQEI
                     EKTRRRVNALENVMIPNYIETIKYIAMKLEENERASTTRLMKVKDMVLKKALEEKKKN
                     DLVV"
     gene            24416..25465
                     /locus_tag="KR257_002385"
     CDS             24416..25465
                     /locus_tag="KR257_002385"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861761.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="putative 2-aminoethylphosphonate ABC transporter
                     substrate-binding protein"
                     /protein_id="HBH0031068.1"
                     /translation="MKEFIFTCLCIVVITFMTSCISTTPQTTQGKGNNKLTIYAALEE
                     EQIAYYMEGFREEYPNIDVEIVMDSHGVIASKLLAEKDNPQADIIWGLSAMNMIELKK
                     DGALEAYKPKNYDKVDKKFKDTEDDVSWVGMSVPETAIVVNYKELKKLGIDIPKSYED
                     LIKPEYKGLITMPNPASSGTGYLTVSGLIQMMGEKDAYNYMDKLHKNIATYTHSGSKP
                     AKLAGSGEYPIGITLGYRATQQLSSGEPIEVVFPKEGSGWDLEANALVKKDNIKKEAK
                     LFLDWAISDSAMDRYAHEVAVTSIKTDNPVPKGYSKQPFEQLIKEVDLNSAAKNRSTV
                     LKTWESKYGSKSESK"
     gene            25561..26550
                     /locus_tag="KR257_002386"
     CDS             25561..26550
                     /locus_tag="KR257_002386"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728969.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="HBH0031069.1"
                     /translation="MSYLKINNVFKSYDQKKVLNNISLDIEEGEFLCLLGPSGCGKTT
                     LLRIIAGLEDVNSGTIILQDKDITNLEPSKRGFGIVFQSYALFPNMTAYNNIAFPLKE
                     RKVSKEKIDNKVKEVLETVGLTNEAHKYPKALSGGQQQRIAIARALALEPKFLLLDEP
                     MSALDAKVRHKLRMDIKRLQKELNITTIMVTHDQEEAITMADKIAILNGGDIMQIGTP
                     EEIYQNPQNLFTAQFIGDTNCFDNGDSILTVRPEYVQIEKSTKENYQGIISNIEFRGN
                     LLRVEIKDKLNENFIISDVSIKEWVNLNLVEGDLVKISIDEKYYLKYPKVKGA"
     gene            26555..28273
                     /locus_tag="KR257_002387"
     CDS             26555..28273
                     /locus_tag="KR257_002387"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861730.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="putative 2-aminoethylphosphonate ABC transporter
                     permease subunit"
                     /protein_id="HBH0031070.1"
                     /translation="MNNNAISSKSISLKSKMNLDIKKCMLTVLVMSLVIFLLAPIIYL
                     FVQAFLDKDGVFVGLQNFQEYLASESLLNSLKNTVFVSVISTVISLTLALVYAYALTR
                     TKIKFKGFFKSLAMFPMFAPTMMHAIGLVYLFGNQGLVTNLLGVHVPIYGAVGIILAQ
                     IIYVFPQSFQILYISLSSTDYRLYEASNTMGISKIREFISITIPSIKYSLISSAFVSF
                     TLCFTDFGAPKVIGGEFNVLSIDVYKQIIGQQNMPMGATVSILLLIPAIISFIVTKKI
                     EKNQNSYITSKSIPYKVKTNKLRDSILGGVVGIIAFGIIAVMLTVILSSLISVWPYDL
                     RLTLEHFSMKNSIDGIKPFINSIKMSLFTAILGTSFVFLFAYLNEKTEKAPYLKSFGY
                     FLSTLPMALPGLVLGIAYVLFFNKLEFNFMDTIYIKNLFNGLYGTLLIMVICNIVHFF
                     SVAFITATTAIKKVDKELDMVAKSMGINSASILKNVTIPLCLPAVLENFMYFFLNSMV
                     TISALVFIYTASSKVAAISIVQLDDKGSTAQAAALAVLILVTNILVKVIYEFIKNRLE
                     KRTNFN"
     gene            complement(28355..>28511)
                     /locus_tag="KR257_002388"
     CDS             complement(28355..>28511)
                     /locus_tag="KR257_002388"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426756.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=2
                     /transl_table=11
                     /product="GGDEF domain-containing protein"
                     /protein_id="HBH0031071.1"
                     /translation="VEENSTNELKLSMSIGYAIFDEKVDVSLFDTYRRADSQMYDNKR
                     KINKQYQ"
BASE COUNT        10956 a         3356 c         5043 g         9156 t
ORIGIN      
        1 tactttagcc tataaatatt taaatcttaa aatgttctct ttgagataag tttatttcag
       61 agtcacaatt tccacaacag taagatgttg agacatcttt aaatttttca gtattctcat
      121 caaagttcat ttttttcttt gcaataattc ctaccttagt taaattagaa ccacaattat
      181 tacagttttg aattttgcat aggttatata gtttatcaag tgtaatatct tctaataatt
      241 catcacaatt acaacatctg atagaagaaa cttcactaca catttcaata ggttcagctt
      301 ctttagaaga aaatttatat gttatgtcat ttgatacttt ataacctgta tcaaatatat
      361 tagaattaca acttggacat aagtactttg gaagatatat atcttttttt tcaaaagtat
      421 cactactaat attacagttt aattcatcta aaattggtct ttcatctagg ttattacctt
      481 tatttaagct tagaagataa ttataaattt ttttatcttc attctgtttt gatgtatcta
      541 acaaatgctc cattatatta gtgtattttt tgttttttga aggcatgttt aaatccagat
      601 aattgttttc aatagcaaag catactatat tgaaatagtt atatttaact gcaaaaaata
      661 ataacatttc atcaaatact ttatctatta ttttgtcaga aatacttatc caaaaatctg
      721 gtgactctaa gtaaactttc ctactaagtt catctaactc ttcatctata ttatttatat
      781 tattttcatt aactttcata tcatcacttc cttttaaata tcttgtgtat aaactatttg
      841 ttactatttt ttatataaaa taaaatctta tataaaaata tatcatatta taatttacaa
      901 gtatagtcta aatagagctg tttttaagca aagttttata aatgactatt aaaatataaa
      961 gtaacagtat aaagtttact tataaattaa atgtaaacct aaatgcttat aatagttgac
     1021 aaaaaaacgt ctttatttta tactaaaaca aagctttaat agaagctttg tatatgtaca
     1081 tataaactaa atgaaataag acatatgaag ggaattataa aaatgaaaaa tactaaagta
     1141 aatattcaag atttaactaa aatgtcaata tgtgtagcat tattgtgtat atcatcttac
     1201 atatatatac cattgccatt tactccagca ggagtaacag cacaaacaat aatgataaat
     1261 ttaatagctt tgattttaac accaagacaa gcatttagta cagttggtgt atatataatg
     1321 ataggtttaa ttgggattcc agtatttggt ggaggtacat ctggtattgg aaagttatta
     1381 agcccaacag gtggttttta ttttgggttt ttgtttgcag cactaattat tagtttatta
     1441 aaaggacgaa ataatgatat taagagatat atactaataa caatttttgt tggaatgcct
     1501 attatatatt ttatgggaac agtatttatg tgctatttta atcaaatgac agtagaagca
     1561 gcactttttg cagcagtagt accattttta attggagata caataaagtc agttattgca
     1621 tcttttttag gcactaaact gaacaatgta ctcagaagaa atctatgata aatctataat
     1681 ataaggaagg gtgtaatgta tgaaggaagt ttttatatta ggaggattga gaagtcatat
     1741 aggtctaaaa aatggaattt ttcaatttgt tcaacctgaa ttactaggag caagtgtttt
     1801 aaaagattta attaaaaagt atgaaattga taaaattgat gagattatat gtggaaatgc
     1861 agttgggaca ggagggaata tagctagatt aatgacttta acagcaggag tgtcaaatga
     1921 agtacctgct tttactgtgg atatgcagtg tgcttctgct atgatgagta tagacatagc
     1981 tttttcaaag gttaaatctg gtcagtgtga tttaattatt gcaggtggtt ttgaaagtag
     2041 ttctctacaa ccaatgcgca catatcataa gaatgataag cgatataata caaataatcc
     2101 aaattataca gttgctcaat tttctcctga tgataatagc caaaatagta tgctcgaagg
     2161 tgcggaaaga gtagcagagt tatatcaaat tgagaaagca gacttggatt tttgggtaaa
     2221 ggaaagtcat aaaagagcaa aagaagcaag agaggaaaaa atacttgaag atattatatc
     2281 tcctataaat aatagtacct atgatgaagg tatacgtgat aagatgagtc aaaggttatt
     2341 agataggatg ccatcaattt taggaaaaga aactattaca aatgcagcaa attcatgtct
     2401 tattaatgat ggagcttcat ttattataat atgttctaag aagtatttag aacatgtaaa
     2461 aaagaagcct aaagcaaaaa ttattaatac atgcacaata ggaacagatg caaccttaag
     2521 tccaacatca gcgatacaag caatggataa acttttagag atagaaagtc ttaattattt
     2581 agatgtatct gctgttgaat ttaatgaagc atttgcagtt atagatgtgt tgtttcaaag
     2641 aaaatatcca gagttaatag atagatataa tatatttggt ggagctttag cgtatggaca
     2701 tccatatggt gcttcaggtg caattattgc attacatctt ttaaaagcat tagaaaagac
     2761 taagggtaga tatggaattt gctctatagc tgcagctggt ggtctaggtt cagctttact
     2821 gcttgaaagg gtgtagatta tgaactatta tgaactttta agaataaaaa aagagaggca
     2881 taaaaataaa aattttttaa ttatagatgg agaaaaatat acttatgaaa atatattgag
     2941 ttatagtgag gaactaggaa aacaaatttc tttaggtgaa aatatcccaa ttttaatata
     3001 ttctaaaaat ataatgtttc agttgattag tttttttgct attaattatt caaaaaatat
     3061 tcctattatt tgtcattata atctttctaa aaaagtatta gatgatattt tattaaaaaa
     3121 taatatttca atcattatat ctgatgaatc tatggacgtt attgatttat atgatgataa
     3181 caataatgaa gtagcaaaaa aagttaattt ttctattttt aatcctaaat ttaatatata
     3241 tatgtatcaa tataagaacc ttataaatta tttagataaa agtatttgta tgggagcttt
     3301 atcttcaggt tctacaagtg ttccaaaggt attatataga acatatgaga gttgggctgg
     3361 attttttcct atacaaaatg gtatttttaa tatctctggg gaatcaatct tgtttgttaa
     3421 tggaacactt agttttacag ggaatctaaa ttctataatg tcagtattat atgaaggagg
     3481 tagtattgta ataagttcag gtcttaattg taaatcatgg ataaggataa taaaacaata
     3541 taatgtaact aacatatacc ttatacctac aaaacttcaa cttttggtta aacacttaaa
     3601 agaaccagta ctcaaagttg taagtatttt tacagggtct caattattat ttgaagatac
     3661 tgcaagaaat ctaaaaaaat atatgccaaa gtctgaaatt attttatact atggggcaag
     3721 tgaattaaat tatattacat atttatgcta tgatgaacta attgaaaaac ctctaagtgt
     3781 aggcagacca tttccaggaa tagatatata tattagagaa ggaaaaattt ttgtgaatac
     3841 agaatatgca gtatataatg caaccaaacc ttattctgtc aatgatattg gatattatga
     3901 taatgatgga tacttaatat ttgaaggaag aagtgatgac attttaaata ttggaggatt
     3961 taaagttagt tctactaaga ttgaaaatga agttaaaaaa attcctcaaa ttgaagatgc
     4021 aattgtattg ccgtactcag acactataag aggaaatcaa attgtattat ttgtaataac
     4081 tatagacaaa attacgaaga aagatttgtt gattaaaatg aaagataatc taatgaaaaa
     4141 tgaaatccca aagaaaatta tctttttaaa ttcatttcca tatacctctt ctgaaaagat
     4201 agatagatta gcattattaa aaatgttata agtataatat ttagtaattt tagtgaacca
     4261 atgtattgat aaaaacatat tgtatatagt aaaggaggct tacaatatgt caaatcaata
     4321 cgatataact gttattgggg gagacctgcg acaagtgtac atggtaaaaa aactaattaa
     4381 taaagggtat tctgtagtca cttatgggat atcaaatgaa attataaatg gaatcgttgg
     4441 aaaatcaact tcactagctg aagcactatc caaaagttcc attattttat gtccaattcc
     4501 atttacaaag aatcaagtta atattgaaaa tacggatgat tgtcttgatg ctactattga
     4561 taacttgcta attaatttat ctcctaatca aatattattt ggaggtaaca taccaactaa
     4621 agtttgtaaa ttttgcgagc aacactctat tcagatttat gattttatga aaatgaatga
     4681 tgttgctatt ttaaatgcag ttgctacagc tgaaggggct atagcagaag ctattaaaag
     4741 aagtataatc aatatacatc aaagtaactg tttagtatta ggttatggaa gatgtgcaca
     4801 aatacttgca aaaaaattat acgctttgga tgcaaatgta tgtgttggcg caagaaataa
     4861 tgatgcaaga agtacggcta atgcatttgg atattccagt atttctttaa gtcaacttga
     4921 tgaaaaactt ttacaatttg attatatttt taacaccata ccagagtgta ttttaacgaa
     4981 agaaaggtta gaaaaagtat cacaagaagt aactattata gatatagctt cttctcctgg
     5041 aggagtagat tattctgttg ttaaagaagc agggattaat gcgactcttt gccttgggct
     5101 tcctggtaaa tattcaccaa agacatctgg tgaaattctt gttaacgcta tagaaaatat
     5161 tataaatgaa agaagggatt agaaatgaga cttgaaggac ttacaattgg agtaggattt
     5221 actggttcgt tttgtactta tgataaaata tttatagagt tagagaattt ggttaaagaa
     5281 ggagctaatg tacacactat attttcagat gtatcacaaa atatcgattg tagatttgga
     5341 aattctgaag agtttatgaa aaaagcatat gaacttacag gaaataaacc tatagttacg
     5401 attgaagagg cagagccatt tggacctaaa ggaattgctg atattataat aatagctcct
     5461 tgtactggaa atactgctgc aaaattagca aatggtatta cagattcacc agtattaatg
     5521 gcagcaaaag gtcatcttcg taatgataaa ccactagtaa tatcaatatc aacgaatgat
     5581 gctctaagct ttaatttcaa aaatattggc attctcctta attctaaaaa tatatatttt
     5641 gtaccttttg gtcaagataa ttgcaaagca aagcctaatt ctatgattgc acatactgag
     5701 ctaataattc caactataga acttgctcta gagaacaaac agctacagcc tgttataaaa
     5761 agtccacatc aatagaattg gttcttataa tattatgtat tagatacaat actagcaaag
     5821 aggctgtctc aaaatagaga gaagcctctt tttcttgttg aaatgatgaa aatatattta
     5881 atttcataca aaaaaatgcc tcatggacta aaaagtctat tttgagctaa tctccgtaat
     5941 ttttgctata ttaaaattat ttacttaatc caatttttaa attagaattt atatcgtttt
     6001 gactcttcaa atatcaatct aactgttgtt gatacaaaag aagaggacat aattaaaaca
     6061 aatactgata gtcctctaat aaacaaatta tctacataat aagttactat tccaatacct
     6121 ccaatcgtta aaattacact tataatcaaa gaaaaaacgc taattgtttt taatttttcc
     6181 atgcttatcc tccttcttat aaacttcaaa tttatctata taatattaaa tatattttat
     6241 ttcatattat ataaaaatca tgaatatata tttttttaat tatactatat gttgtaaatg
     6301 tttgtacatt taactatatt tactttaact tgttaattaa gttttaattt tcattttcaa
     6361 ggatttttat ttttaaactt gatagagtat catattaaaa attcttttta taaagtttta
     6421 tttgcaaaaa atacaaaaat ataaacgtta aaaaaataac gttatcctta agtttttaga
     6481 tgatttcatt agtgatttgc gtaaaaaata aagtgatatc tagttaaatt aagtatttgt
     6541 aaagctagat attattagta gaaatgatgt tatattagat aaaaaataaa atgttaaaaa
     6601 aataacttga aaataggaaa agtaaatgct ataatgttaa taaattaaca taataaataa
     6661 aaaactatct caggaggttg ttaaaatggc tcataaagaa caagtaataa tagaaaataa
     6721 aaaagaaaat gaagttatgt cagttggttt agatactgta aataacgttg aaagcttagt
     6781 taaaaaacta gcaaaaatca gagaagctca aaaaatattt gctacatata gtcaagagca
     6841 ggtagataaa atttttttag cagcatcttt ggcagctaat aagcaaagag ttcctctagc
     6901 tataatggca caaaaagaaa ctggtatggg aattgctgaa gataaggtta taaagaatca
     6961 ttatgcctca gagtatatat ataatgcata taaagaaact aaaacttgtg gtgttataga
     7021 gaaagacgaa gcatttggta tgactaaaat tgctgaacca ataggtgtta ttgcagcagt
     7081 tgtacctaca actaatccaa cttctactgc tatctttaaa gcacttttag ctttaaaaac
     7141 tagaaatgga ataattttct ctccacatcc aagagcaaaa aattctacta tagaggctgc
     7201 aaaagttgtt cttgaggctg ctgttttagc tggagctcct gaaggtataa taggatggat
     7261 agatgagcca tctttagaat taactacaac tgttatgaaa gaagtggatt tgacccttgc
     7321 tacaggaggt cctggaatgg ttaaatcagc atattcatct ggaaaaccag ctattggagt
     7381 tggtgcaggt aatactccag caataattga tgatagtgca gatataaaaa ctgctgtaaa
     7441 ctcaattctt gtatctaaga cttttgacaa tggtatgata tgtgcttctg aacaatcggt
     7501 tatagtatta gaaaatatat acaatgaagt caaaaaagaa tttaaagagc gtggtgctta
     7561 tttattagat aaagatgaaa cagaaaaaat aagaaatata attttagtaa atggaggatt
     7621 aaattctaaa atagttgggc aaacagcttg tactatagca aaacttgcag gctttgaagt
     7681 cccagtagat actaaggttt taataggtga agtagaatca gttgaaatag aagaagcttt
     7741 tgctcatgag aaactttcac cagtacttgc aatgtacaag gcaagtgatt ttgatgatgc
     7801 agttagaaaa gcagaaaaat tagtagaaga tggtggattt gggcatacat cttcattata
     7861 tattgatgat gtaaatcaaa gagaaaaact tgataagttt acttcagcca tgaaaacttg
     7921 tagaatttta attaatactc cttcttctca aggtggtata ggggacttat ataattttaa
     7981 actagctcct tctcttactt taggatgtgg gtcttggggt ggaaattcag tatctgaaaa
     8041 tgtaggagtt aagcatttac ttaatattaa aacagtagct gagaggagag aaaatatgct
     8101 ttggtttaga gcaccagaaa aagtttattt caaaaaaggt tgtttaggag tagcattaaa
     8161 agaacttaaa gatgtaatga ataagaagag agcttttatt gtaacagata cattccttta
     8221 caataatgga tatactaaag cagttactga tttattagat gaaatgaata ttaagtacac
     8281 tacattcttt gaagtagaac cagacccaac tttggaatgt gctaagatag gcgctaaagc
     8341 tatgagagaa tttaatccag atgtaataat atctataggt ggaggaagtg caatggatgc
     8401 aggaaagata atgtggacat tgtatgagca tccagatgta gatttccaag acctagctat
     8461 gagatttatg gatataagaa aaagggtata tacattccct aaaatgggtg aaaaagctaa
     8521 ttttgtagct ataccaacat cagcaggtac tggttcagaa gtaacaccat ttgctgttat
     8581 aactgaccaa gatacaggag taaaatatcc attagcagat tatgaactga tgccaaatat
     8641 ggctatagtt gattctgata tgatgatgaa tatgccaaaa agcttaacat ctgcttctgg
     8701 tatagatgct ttaactcatg cattagaagc atatgtatct atgcttgcaa ccgattatac
     8761 aaatggatta gctttacaag ctattaagag tatatttgaa tatcttccac gtgcatatga
     8821 taatggtgca aaagacccag aagctagaga aaaaatggca aatgcttcta caatggcagg
     8881 tatggctttt gcaaatgcat ttttgggtgt ttgtcactct atggctcata aattaggtgc
     8941 tttccaccat gtaccacatg gtgttgcaaa tgctcttttg ataacagaag ttatgaaatt
     9001 taattcttca gatgcaccaa agaaaatggg agcattctct caatataaat atccagaagc
     9061 attaaagaga tatgctgaaa tagcttcatt tttaggatta aaaggaaatt ctgatgaaga
     9121 gaaattccaa agtttattgg tagctattga agatttaaaa cttaaagttg gtattcctaa
     9181 atctataaaa gagtttggcg ttgaagaatc taagtttatg gattcaatag atgaaatggt
     9241 aattcaagca tttgatgacc aatgtacagg agcaaatcca agatatccac ttatgaatga
     9301 aataaaagat atgtatttaa attcatatta tggaagataa gtttgctata aaatagataa
     9361 aataaaaact cttatacata aaacaaagtt ttattgtata agagtttttt tgtttgagaa
     9421 aatggatagt ttttattctt taatttaaaa ttcaattaaa tagtgttatt ataataataa
     9481 aagaatgttt ttatggttat tatgttgatt ttatgtgtaa catttaagaa tagttatata
     9541 caatataaat gatgaattgg tataaaaagg atatattatc tatatgaagt attgactaat
     9601 taggggagga gtcgaatgac agggagaaat aaaagtttta cattaattac aattcttttt
     9661 ttaacatcat tatttttgac aatggggtat atctatatag aagatacaaa acatcttctt
     9721 atgtcagagg caaaaataca tataaaagaa gttgcagtac aaggctctca actagcacaa
     9781 agacaaattg aaaaagattt agatgtttta aatatttttt ctaactatta tgcttcaaat
     9841 ccagatatac ctaatgagga aaaaatgaaa aatcttttag atgaaatgga aaatcaaaaa
     9901 ttttacacta tggcaatagt tgatataaat ggtaatgctg aaaataccaa aggtgataag
     9961 ttttcagtga aagatagaga atttttcaaa aactcaatta aaggtaagaa gtatgtttca
    10021 agtccatatg ttgatgaagt aaataagtct ataaagaaga ttgctatttc agtaccatta
    10081 ttaaataatg ataaagtagt tggagtttta tattgtactt acaatatcaa tactctgatg
    10141 aaacttatta atatatcttt ttatgaaaat aatagtatat cttatgttgt aaaaaatgat
    10201 ggtacaatta tccttcatcc acaaggggat agcctatcaa aaaatattta taaattgtta
    10261 gaacaggata atgatattca agaagtaaat agattaaaaa aagaattgca agaaaataaa
    10321 acaggtgcaa ctgtattaaa tatgttggaa gaaagaagat atttagggta tgccactatg
    10381 gataatggga atagtgaaaa taattatata aaagactgga atttaatttt ttcaattcca
    10441 gaaactgttg tatttagtaa ttcaaaacaa ataatcaaca gagctgtata tgcagtgtta
    10501 tctattgtat taatatttgt tgcaattatt ttttatataa tttatataaa aaaatctaat
    10561 gaaaaagaaa tattaagttt ggcttatgaa gataaagtta catatatagg aaatcaaaat
    10621 aaattttata gagaatgtag taagtatctt ttagataaac catctttaaa ttatattata
    10681 gtatattttg atattaataa ctttaagatg attaatgata cttttggata tgaatttggt
    10741 gacaatttat taattacaat agcaaaagct ttaaaagaag aattaacaga aggtgaggta
    10801 tatgcacgac tttcaagtga ttattttgca attttctgtg attataaaaa tggaagaaat
    10861 aaaattataa gaaaacttga taatatacga agtaatattg aaagtaattt gagtatagtc
    10921 tttgaaattt ctctgtgtgt gggtatttat tttgttgaag aaggtgaagt agatattcaa
    10981 aaggctgtaa ataaagcaaa tatggctagg tctgttgcta aaggtaaaaa tataaattat
    11041 gctatttata atgaagatgt taggaataag cttagtgagg aatcaatgat tttagacgat
    11101 ataaaaatag cattggtaaa aaatcaattt gaagtgtatt atcaacctaa gttttcactt
    11161 gtaactggag aaatgatagg gagtgaagca ctaataagat ggaatcatcc agaacatggt
    11221 tttataagtc ccgcagtatt tattccaata gcagagaaaa gtaagttgat tttaaaaatt
    11281 gggagatttg tatttgaaag ggtttgcaat gatttatatg aatggaaaaa gcaaggtaaa
    11341 aagatagttc cagtttcagt aaatttatct agggtcgagt tgtatcaacc agatattgta
    11401 aaatttatca ataaaacaat aaaaatgtat aatttaagtt cagatttcat tgaaatagag
    11461 ataacagaaa ctgtggctat taatgagtta aatattttaa agaatgtttt aaatgagttg
    11521 aggacgtatg gattttctat ttctatggat gactttggta caggatattc ttctattagt
    11581 tgtttaagag atatgccaat tgatatattg aagctagata agtcttttct tggtggcatt
    11641 gaacatgatg agagaagtcg caatatagca aaatcaatag tgtctctagc aaaatcacta
    11701 gatttagttg taattataga aggtgttgag agtaaagaac aagctgagtt aatgaaacaa
    11761 tttggatgtg atttagttca aggattttat tttgcacgac caatgccagc taagaatttt
    11821 ttagatttac tttaaaacaa aatttgattt ttatataaag cactattatg aatgcttgat
    11881 tttaataaat cattgctaaa taattagtgt ttttttattt tatcaatgta ttgtctaata
    11941 taaagcaaaa aataattgta ttttataaaa attatattaa aaataaattt attttgctaa
    12001 taaacatgtt attaacaaaa gaatagtact ataatgtata gatgataaaa actttaataa
    12061 aaatttagtg tataggagtt gtttaagtat gatagatata agtattgatg acaaacttaa
    12121 ggaaagatgg cctaatgcta agctgggttg cattcaagca aaagtagcag taaataaaag
    12181 ctcagaaaaa ttaattaatg aaataaatga gttttgtgat actataaatc aaagtctaaa
    12241 agttgaagac attacgaaac tagataaaat taaagatgca agaaatgctt ataaagagct
    12301 tggaaaaaat ccaagtagat atagaacatc ttcagaagca ttggttagaa gaattattca
    12361 agggaagggt ctttatacaa taaataatat agtagaaata aacaatttaa tatcaataaa
    12421 atcattatat ccagtaggta catataatgt aagcaaatta cattcaccag tatgttttac
    12481 tgtaggagat gaaggagaac agtataaggg tattgggaaa gaattaataa atatagaaaa
    12541 tcttcctata ttgtctgatt cagtgggtaa atttgggagt ccaactagtg attctgaaag
    12601 agcaatgata acagaagatg caaatgaaat attaatttgt atattttctt ttagtcaaga
    12661 atctgatatt gaagaatatt ttggatatgc taaggaatta cttaaagaat atgcagatgg
    12721 aaaagatata gaaactaaaa taattaaata gaatctatat aacaacgtta tgttaagcta
    12781 aaattcaata taaaaataag ttaagataaa gaaactaaca caaaattagt ttctttttta
    12841 aaatagtagt ttagtgttac aaaaatagat agatagtccc acgattatta aaagtatggt
    12901 aatatattaa tatagcagag attgtgttta agggattttg aaagggggga tttataataa
    12961 tcattttatc taaaagataa aatggtttta tagaaataac tatatattta aaaatataaa
    13021 taatgataca gtaatttggg tatataaaat aaggcataca tggttttgtt taaaaaccaa
    13081 taaggtacat aggtaattac aatgtaagga aggatttaat tatgattgat ggaaaagagg
    13141 taaaacaaga aagtggacaa aaaaatctaa aatttaagat agctatagta gtaggtgttt
    13201 tgtttgtagc ttatatagga atggcaatct tttttagaaa tcatttttac tttggaacga
    13261 ctattaatgg cgtaaaggct tcaggaaaaa cagttgagca agtaaatgat ttgttagcat
    13321 ctagtactaa ttcctatact ttaaacttag aggaaagaaa caataagaaa gaacaaataa
    13381 aagcaaaaga tattgattta aaatttacac cagatgataa agttcaaaag ataaaagata
    13441 gtcagagcgc tattggatgg attggtggaa tatttaaatc taaagagtat aataatatga
    13501 taactctttc atataataaa gatttactag aaaaaaggtt taatgcttta tcttgttttg
    13561 atagtaaaaa tgttgtagaa cctaagagtg cttatcctaa gtatgatagc actaaaaacg
    13621 cttatgttat agtaccagag gtacttggaa acaaagtgaa aaaagatgat ttttataagt
    13681 tagtacaaaa ctcaattaat tctgggaata cttctatttc tctggatgaa agtaaagttt
    13741 atgaagcacc aaacaacaca aaggattcag aaaagttgaa acaagctatt aagacattag
    13801 ataagtatgt tggtgtagtc gttacatatg attttagtga ccgtaaggaa actttagatg
    13861 gttctgaaat taataaatgg ttaaaagtag actcagaaaa gaattatgac ataacttttg
    13921 ataatgatgc tatggtagaa tatacaagag gtttaagtaa aaaatacagt acttttggtg
    13981 actcaagacc atttaaaact gccacaggta aagatattac aatttcaggt ggaatttatg
    14041 gttggttgat agataaaaag aaagaagctg aagcattagt tgatgttgta aaagctggta
    14101 aaaatgttac aagagaacct atttacatac aaaaagctgt atctcgtaat aaagatgata
    14161 ttggaaatac atatgtagag attagtcttt ctggccaaca tatgtggttc tttaaaaatg
    14221 gagaaatgct tgtatcaaca gacgttgtaa caggtgattt agctagagga tttgctacac
    14281 catcaggtat atatcctctt aattataagg ctagaaatgt ttcattaact ggtcaaggtt
    14341 acagttcacc tgtaagttat tggcttccat ttaatgggaa cataggcatt catgatgcta
    14401 cttggagaaa ttcttttggt ggaagtatat ataagtcttc aggttcacat ggatgtgtaa
    14461 atacaccttt ttctaaggca aagaaaatat atgaaaatat agaaccaggt acaccaatta
    14521 ttttatacta gtaaatgtgt tgctaacagt taagcgaagt catcctagtt tatttaggat
    14581 ggcttccttt ttatataaag cttattgaag tttacagaaa gactacttaa aaggagaaat
    14641 acataatgaa tgaaaaatta actaaaattt tagaagaagc taagaatgat gatgaattta
    14701 gaaaggaact tataaaaaca agagaacaac gtgatgttat ggattcattt tgtaaggttg
    14761 ttacatctag aggttatgat atgacagtag gggaactttt ttctatggga gaagaatata
    14821 catccaatct actgaaaagt gtaaatggag gagcagcata tcctattgaa gattggagtg
    14881 attggtacga ggattttttt ataatgttgt cgaatatata gagtaactaa tgatattatc
    14941 tacttaagat taatacattg ccttaaaata aaactattag aactaggtgt aagttttatc
    15001 aatctttaaa aatattgatt tatttctaac tagatataaa aaaattagat taaaaataag
    15061 gtgacaaaaa tcgatatagc ttgatgattt ataaaagtta gataaaatag tgcgagatat
    15121 ttctaaaaat tcaaaaaaaa caataaactt caatggttag aggttgaaaa agaatataaa
    15181 aaacttttat atgtaataaa ttaaattaaa attataaaaa aaataaaata aaaatttaaa
    15241 atgtcgacat aacgttaatt ttaaaacaaa ataacgctat tgacaaacta tatcgcttta
    15301 aattataatt attgaaaata atggtattta aaaaccatac tcatgtcata gtctaaaagt
    15361 aagtcaaaaa aggatgtaaa tctaggcaag tactattcta aaatatgttt tattaagaaa
    15421 taaacgttga aaaatattaa ttattatata aaaatgctgt ttatacttta acaatgaggt
    15481 agtaatctaa ttagaataaa aaaatctaat tggttatata catagtaaaa aggtaagaga
    15541 ggtgatttgg atggcttttg aaataataaa aagcattgtt gaggcagagc agacagcaga
    15601 cagtatcaaa gtaaaagctg ttactgatgc agagtctatc agagctgatg ctgtaaacaa
    15661 atgtgaaagc atatttgctg atgtaaaaaa acaagcaaag cttatggaag aaactcttat
    15721 tgagaaggca gtcaccgaca gtagagcaga ggttgataaa atcttagcta atgctaaaag
    15781 tgaatgtctg aaaattgaaa aaactgctga agaaagaaaa agtaaggcta ttgaagcggt
    15841 tattggaaag gtagtgagat aatatggcaa tagttaatat gaacaaaata tctattgttg
    15901 gcttagaagc tcaaaaaagc cagattttaa agctacttat gaaccgtggg tttgttcaga
    15961 ttgatgatag tgcctttctt actgaggagg aggaattaaa aaattatctt gtaaaagata
    16021 gtgaagaatc tgaagttata atgctagagc agaaaatgtc tcatgtaaac caagcaatta
    16081 atattgtttc ttcactagtg aaacaaaaaa aatccctact tgcaccaaaa agagagttta
    16141 acaaaattga tagtgaaaaa gaagggcaag tttatgctga agctctggag ttaaacaatt
    16201 tgcacaagga gataggtaca ataaggtcta acataaactt acttaacaac aataaaagta
    16261 tgttagaacc atgggtgaac tttgatattc ctattgaaaa tatggaaact aagtatacaa
    16321 aaactatact tggaactgtg cccataagcg caaacattga tgctttaaga gtaaaattag
    16381 aagatgaaat accagaaagt gttattggga ttgtcaattc tgacaagtta atgaactatg
    16441 tttatttaat tactttaaaa gaaacttttg atgatgtttt agaagtttta aaagaattta
    16501 atttttcagt ggtttcatta ccaaatgaag aaggtacacc gttacaagct atcaagaaat
    16561 acaatgaaat gataattaga caggaaaacg tttctaagga caaaacagag gaaattaaaa
    16621 gacatgcaga tagtatacac atgcttgaaa acctatatga tttttacact atagaaagag
    16681 accaaaaaaa gattatagag agacttgtca aaacaaaaac aacattctgt cttaatggtt
    16741 ggttaccaag caaaagggca gatgaattaa ttaaagaaat tacagaaaag tttgattgtt
    16801 gtgttcagac tgaagaagga agtaaagaag aaggcttccc aattctgctt gaaaacaata
    16861 aattagtaac accttttgaa agtgtaacta acatgtacag ctatccaagt acaaaagata
    16921 ttgacccaaa tacaatttta actttcttct ttgttatatt ctttggaatg atgctaagtg
    16981 acgccgcata tgggttaata attgcagtag tttgtggatt tgttgtatat aaattaaaga
    17041 tacaaaaagg tgaaggaaat ttaattaaac ttattggtat ctgtggagtt tcaactactg
    17101 tatggggtct tatattcggg ggtattttgg gggatttaat tcctataaaa gcattaatta
    17161 atcctttaga ggatgttatg acacttatgg gaatgtcgtt actgttcggt attatccata
    17221 tatatgtagg tttgggaata aaagcatata cattaataag aagtggaaag gtaatagatg
    17281 caatctttga cataggtttt tggtatttgt gtataacagg tgtatgtcta cttataatac
    17341 cttttgttgc aggggacata ggtgtatttt cagaagtagg aaaatattta gcaattatag
    17401 gtgctatagg tcttgtactt actcaaggaa gaagctttaa aggtattcct gttaagcttt
    17461 ttaaaggatt ttcaagtctc tatggtataa caagttattt tgctgatata ttatcttata
    17521 caagaattat ggcgctttgt ttaacaacag gagttatagc acaagttatc aaccttttag
    17581 gggctatagc tggtccgata cttgcagttg taattggtgt tgtaggacac acaataaacc
    17641 ttcttataaa tgcactaggt gcatatgttc atacaagtag gttacagtat gtagaatttt
    17701 tcaataagtt ttatgaaggc ggaggagttc cttttgttcc gtttaagtat aaaacaaaat
    17761 atacaagcat taataaaaag gagatgtaaa tatggaattt ttaaacgcgt taggaaatgg
    17821 tcaatttttg gcaatatcag gagctgctat agcagcatta tttgcaggta tgggttctgc
    17881 taaaggtact tcaatagcag gtcaagccgc agcaggtgtt gtaacagaag accctagtaa
    17941 attcggtcaa cttctagttt tacaacttct tcctggtaca caaggtctgt atggatttat
    18001 catagctttc cttattttat caaaagcagg gattattggt ggagatgcaa taccaacatc
    18061 agctcaaggt ttacaacttc ttatggcagg acttccaatt ggtttagttg gtttagtatc
    18121 aggtatagca caaggtaaag cagcagcagc aggagttgga atagttgcaa aaagacctga
    18181 agaacttggt aaagctataa catttgcagc aatagttgaa acatatgctc ttttaggact
    18241 acttgtttct ttcttagctt acaatggaat tgcaattggt taattataaa ttataattca
    18301 taagtaaaaa aaatgaaaag gaggaagcac tcctatgggt aatgaacaaa aaatgattga
    18361 cagaattata gctgatgcca aacaagaagc acaagaaata ttggataaag ctaaaagtga
    18421 agcagattta aaagtaaatt cagctaatga aaaagctgaa aaggaaatgg cttcctatac
    18481 aaagcttgca gaggcagaag cagaaaaagc ggcttctaag gaaatatcag gagcttatat
    18541 ggaggctaaa aagcaaatat tatcaaaaaa acaagagatt ttagaagagg taattttaga
    18601 agctaaaaac aaacttttaa atcttaaaga taatgaatat gaagagatta tactaaacat
    18661 gattgaaaaa tcaaattgta cagatgattc agagatagta ttatctaaaa aagataaaaa
    18721 aacattaaaa gatgtgctat caaaaaaagg cattaaagtg tctgatgaaa ctagagatat
    18781 tactggaggt ttcatagtta aaaaaggtga cattgagtac aattattcat ttgaagccat
    18841 aattgcagta gagcatgaat atattgaaca aattgcagca gaaattttgt ttaattaagg
    18901 aggggttaaa aaatggcaga agaaaaaact tatccctatg ccgttgcacg aataagagtg
    18961 cttgaaaaac agcttcttaa cagacaaatg tttattcaaa tggcagaagc caaaagccct
    19021 gaagactctt taagaattat agctgaggca ggttatgctg atacatcaaa taataatata
    19081 cataattttg agaatatttt gactcaagaa ttatcaaaga catatgaaat tcttaaaagt
    19141 ctagctcctg aagaaaaatt tgttgatgta tttctttata aaaatgacta tcacaattta
    19201 aaagtgctga ttaaagaaga aatttctggt gtagatggtg agaaatattt aattgatgga
    19261 ggtacaattc ctcttattaa gcttagagaa tctttagcaa atcgtagttt tagtgattta
    19321 cctaagataa tgtcatcagc tatattagag gcatttgatg tttataataa gacacaaaat
    19381 ggccagatgg ttgatattgt tctagataaa gcaaccttta ccagtatgaa agaaactgct
    19441 aaagaaagcc aaaacaaatt tgtaatagat tatgttatga aagtttgtga tttaacaaat
    19501 ctaaagagtt ttataagagt caaaaatatg aagaaagatt ttgatatgtt tatgaatgtg
    19561 tttgtttcag gtggctcact tgataaggaa aaattcttag aagctttttc ctcagatact
    19621 ccagcatcat gttttaaatc tacttcttac tctgatgtct gtaaaaatgg catggatagt
    19681 ggttttactg tctttgaaaa actttgtgat gactatctta tggaatatgt tagaggagca
    19741 aaatttaagc ctcttacatt agaaccacta attgcatatt tatatgctaa agaatcagag
    19801 ataaaaacaa ttagaattat tttgactagt aagcttaata atatagacgc agatactata
    19861 aaagaaaggc taagggatgc ttatgtataa ggtaggagta gttggagata aagatagcat
    19921 catgggattt ttagctcttg gaatagatat cttcccagcc tatgatagtg acgaaattaa
    19981 aaaaagtata cataagttgg ttgaagatga atatgcgata atttatatta cagaacaggc
    20041 atcattgctt gcaaaagaat caatagcaaa atacaaagat taccaacttc ctgccattat
    20101 agttattcca ggtattggag gaagtatggg attaggtatg aatgaagtaa gagaatctag
    20161 taaacgtgct ataggtgcag atatattatt taaagaatag atgaaagttg aataaaagac
    20221 aatctcaaat tttattggtg ctaaatatat gtgctaataa aatataggag ggaatattta
    20281 aattttgata aagtatatga ttgcaggtga gagaatatga aaacaggcac aattgtaaag
    20341 gtgtcaggac cgcttgttgt agcggagggc atgagagatg cgaatatgtt tgacgtcgta
    20401 agagtttcag ataaacatct tataggcgag attatagaaa tgcatggaga taaagcttct
    20461 atacaggttt atgaggaaac ttccggtcta ggaccagggg aagaagtagt ttctcttgga
    20521 atgcctatga gtgttgaact tggaccaggt cttatttcaa ctatttatga tggtattcaa
    20581 cgtccacttg aaaaaatgta tgatatttca ggtactaata taactaaagg tgttgaagta
    20641 tcttcacttg atagaacaac taagtgggaa tttaaaccta aaaaatctgt tggtgataag
    20701 gttgtagcag gagatataat tggtggcgtt caagaaacag cagtagtaga atgtaaaatt
    20761 atggttcctt atggagttaa gggtactata aaagaaatat attctggtga atttactgtt
    20821 gaagatacag tttgtgttat tacagatgaa aaaggtaatg atatacctgt aactatgatg
    20881 caaaaatggc cagttagaaa agaaagacca tatagagaaa agaaaacacc agattcactt
    20941 cttgttacag gtcaaagagt tatagataca tttttcccaa tcacaaaagg tggggtagca
    21001 gctataccgg gaccttttgg aagtggaaaa actgttacac agcatcagct tgctaaatgg
    21061 gcagatgcag atatagttgt atatataggc tgtggcgagc gtggaaatga aatgacagat
    21121 gttcttcttg aatttcctga attaaaagac ccaagaacag gcgagtcact tatgcaaaga
    21181 actgtgctta tagcaaacac atcagatatg ccggttgctg cacgtgaagc ttctatatac
    21241 actggtatta caatagctga atattttaga gatatgggat atagtgttgc acttatggca
    21301 gactctacat caagatgggc tgaggctctt agagagatga gtggtcgttt agaggagatg
    21361 cctggtgaag aaggttatcc tgcatactta ggttcacgtc ttgctcaatt ctatgagaga
    21421 gcaggaaagg taaattgtct aggtatggat gaaagagaag gaacacttac agcaattggt
    21481 gcagtttctc ctcctggtgg tgatacatca gaacctgtca gccaagcaac gcttcgtata
    21541 gtaaaagtat tctggggtct tgatgcatct ttagcatata aacgtcattt cccagcaatt
    21601 aactggttga ctagttattc actctatcag gaaaaagttg atgtatgggc agataaaaat
    21661 gtaaatgata atttctcagc tcaaagagct caagctatga aacttttaca agttgaatct
    21721 gaacttcaag aaatagttca attggttggg gttgattcac tttcagatgg agatagattg
    21781 atactagagg ttactcgttc tataagagaa gacttccttc atcaaaactc tttccatgaa
    21841 gttgatactt atacatcact tcataaacaa tatagaatga tgggacttat attaaaattc
    21901 tataagtcag cacaagatgc tatcaagcaa aatgttacta taaacgatat tatcaagctt
    21961 tcagttcttg aaaagattgg tcgtgctaag tatgtagaag aaggcgatat agatgcagct
    22021 tacgattcaa ttgaagatga aatagacaac gagcttgcag accttattaa aaagaggggg
    22081 gctgaagaac tatgataaag gaatataagt caatacaaga ggtagccggt cctcttatgt
    22141 taataaacgg cgtagaaggt gtaaaatttg atgaacttgg agaaattgaa ctttcaaatg
    22201 gagaaattcg tcgttgcaaa gttctagagg taaatggaga tactgcactt gttcagcttt
    22261 tcgaaagctc aacaggtata aaccttgctg aaagtaaagt tcgtttttta ggaaagagtc
    22321 ttgactttgg agtttcacca gatatattag gtcgtgtttt tagtggaatg ggtagaccta
    22381 ttgatggagg tccagaaatt ataccagata aaagacttga tataaatgga gctccaataa
    22441 atccagcagc acgtgattat ccggccgagt ttatacaaac tggagtctct gctatagatg
    22501 gacttaatac attggttaga gggcaaaaac ttcctatatt ctcagggtct ggtttgccac
    22561 atgccaatct tgcagttcag attgcaagac aggcaaaagt acgtggaact gattctaagt
    22621 tcgccgttgt atttgctgca gttggtataa cttttgaaga tgctgaattt tttataagcg
    22681 attttaaagc aactggtgca atcgaccgtt ctgtagtgtt tgtaaacctt gcaaatgacc
    22741 cagctgtaga gcgtgtatct acacctagaa tggcacttac agcagcagaa taccttgctt
    22801 tcgagcaaga tatgcatgta cttgttataa taacggatat tacaaactat gcagaggcat
    22861 tgcgtgaagt ttcagcagct aaaaaagaag ttccaggacg tcgtggatat ccaggatatc
    22921 tttatactga ccttgctact atgtatgaaa gagcaggaaa aatgaaaggg catgaagggt
    22981 ctataactat gattccaata cttacaatgc ctgaggatga taagacacat ccaattcctg
    23041 accttacagg atacattaca gaagggcaaa ttatacttag ccgtgaactt tataaaaaag
    23101 atatacagcc tcctatagat gttttaccat cactttctcg tctaaaagat aaaggtattg
    23161 gtaaaggtaa gactcgtgaa gaccatgcag atacaatgaa ccagcttttt gcagcttatt
    23221 caagaggtaa ggatgcaaaa gaacttatgg ctatacttgg tgaatctgca ctttctgaga
    23281 ttgatttaat gtatgctaag tttgcagatg aatttgagaa agaatatgtt tcacaaggat
    23341 ttagaactga tagaactatt gagcagacat tagaaatcgg atggaagctt cttagtatgt
    23401 taccaaaaag tgaacttaaa cgtatccgtg atgaatattt tgaaaaatat atgcctaagg
    23461 agtgatatct gtggctagat taaatataaa tccaacacgt atggaaatga ctagacttaa
    23521 gaaactcctt aaaactgcta caagaggtca taagcttctt aaagataaac ttgatgaact
    23581 tatgaaacaa tttcttgaga ttgtaagaga aaataagcga ttgcgtgaag aagcagaaaa
    23641 tgctcttgat actgcttata aaaactttat aatcgcaaga gcagttatga gtcaggagta
    23701 tctgggttca gcacttatga tgccaaagca atcagtttca gtagatgttt ctacgagaaa
    23761 tataatgagt gttgatgttc ctgtgtttga ctttaaaact gaaaacaatc aaagtgatat
    23821 ttatccttat ggtcttgctt ttacatcagg tgaattagat tctgttatgg aagctttctc
    23881 agatgctatg caaccacttt taagacttgc agaaagtgaa aaaagtgcac agcttcttgc
    23941 acaagagata gaaaagacac gtagacgtgt taatgctctt gaaaatgtaa tgataccaaa
    24001 ttacattgag actattaagt atatagctat gaagcttgaa gaaaatgaga gagcaagtac
    24061 tactagactt atgaaggtta aggatatggt gcttaaaaaa gcacttgaag aaaagaaaaa
    24121 aaatgatttg gttgtataat taaatactta taaaaataag tctaacattc tactttatag
    24181 aggttagact tattttttat gtttaaatta aaatgtagat actataaaaa ttaatatatt
    24241 gtttaaaaac agactgtatt taactaaaaa taatatattt aacaaaaatt tctaaaaatt
    24301 aacgaactgt taatttacac ttaactttat attaacaaat taggtgtatt atataaacat
    24361 aagcaaaaac aataaaaaac aaataaaaaa aggaaaaaac acaaaggggg aagatatgaa
    24421 agaatttata tttacttgtc tgtgcattgt agtgattaca tttatgacaa gttgcatatc
    24481 aacaacacca caaactactc aaggaaaagg aaataataaa cttacaatat atgcagcact
    24541 agaggaagag cagatagctt attatatgga aggttttaga gaagagtatc ccaatataga
    24601 tgtagagata gttatggatt ctcatggtgt aatagcttca aaactattag cagaaaaaga
    24661 taatccacaa gcagatatta tatggggatt atcagcaatg aacatgatag agctaaaaaa
    24721 agatggtgca cttgaagcat ataagcctaa aaattatgat aaagttgata aaaaatttaa
    24781 agatactgaa gatgatgtat cttgggtagg aatgagtgtc ccagagacag caatagtagt
    24841 taattataag gaacttaaga aactaggtat agatattcca aaaagttatg aagatttaat
    24901 aaaaccagaa tataaaggac ttataacaat gccaaatcca gcatcatctg gaacggggta
    24961 tcttacagta tcagggctta ttcaaatgat gggtgaaaaa gatgcttaca attacatgga
    25021 taaattacat aaaaatatag ccacatatac acactcgggt tcaaaacctg cgaagttagc
    25081 tggctctgga gagtatccaa taggtattac acttggatat agagctacac aacaattatc
    25141 tagtggagaa cctatagagg ttgtatttcc aaaggaaggt tcaggttggg acttagaagc
    25201 aaatgcctta gttaaaaaag ataatataaa aaaagaagca aagctatttt tagattgggc
    25261 aataagtgat tcagctatgg atagatatgc acatgaagta gcagttactt ccataaagac
    25321 agataatcca gttccaaaag gttattctaa acaaccattt gaacagctta taaaagaagt
    25381 tgatttaaac tctgctgcca aaaacagaag tacagtactt aaaacttggg aatcaaaata
    25441 cggttcaaaa tctgaaagta agtaaagttt aaattaataa tttagatgaa agaattttag
    25501 aagaaaaagt aggatataaa atttaaaata aaaaaataac tatataagga gagataagat
    25561 atgagttact taaaaataaa taatgtgttt aaaagttatg accaaaaaaa ggttttaaat
    25621 aatattagtt tggatattga agaaggggaa tttctatgtt tactcggacc tagtggatgt
    25681 ggtaaaacta cattacttag aataatagca ggtcttgaag atgtaaatag tggaactata
    25741 attctccagg ataaagatat tacaaattta gagccatcaa agagaggttt tggtatagta
    25801 tttcaatcat atgcattatt tccgaatatg actgcttata acaatatagc ttttccacta
    25861 aaagagagaa aagtttcaaa agaaaaaata gataataaag ttaaggaagt acttgaaaca
    25921 gttggattga ctaatgaagc tcataaatac cctaaagcat tatcaggtgg acaacaacag
    25981 aggattgcaa tagcaagagc attagctctt gaaccaaagt ttttactttt agatgaacca
    26041 atgtctgcat tagatgcaaa ggttagacac aagcttagaa tggacattaa aagattacaa
    26101 aaagaactta atataacgac aataatggta acacatgacc aagaagaagc tataactatg
    26161 gcagataaaa tagctattct aaatggagga gatataatgc aaatagggac tccagaagaa
    26221 atataccaaa atcctcaaaa cctatttaca gctcaattta taggagatac aaactgtttt
    26281 gataatggag attctatatt aactgtaaga ccagaatatg ttcaaataga gaaatcgaca
    26341 aaagaaaact accaagggat aatatcaaat atagagttta gagggaattt attgagagtt
    26401 gaaataaaag ataaattaaa tgaaaatttc ataataagtg atgtttctat aaaagagtgg
    26461 gttaatttaa atttagtaga aggtgacctt gtaaaaataa gtatagacga aaaatactat
    26521 ttaaagtatc caaaagttaa aggagcataa gtgtatgaat aataatgcta taagttctaa
    26581 aagtataagt cttaaatcaa aaatgaattt agatataaaa aaatgtatgc ttacagtatt
    26641 agttatgtct ttagtaatat ttttattagc acctataata tatctatttg tacaggcttt
    26701 tttagataaa gatggagtct ttgtaggatt acaaaacttt caagaatact tggcttctga
    26761 atctctatta aattctctaa aaaatacagt atttgtatca gttatatcaa ctgtaatatc
    26821 actaacactt gcattagtat atgcatatgc attaactaga acaaagatta aatttaaagg
    26881 tttttttaaa tcattagcta tgtttcctat gtttgctcca acaatgatgc atgcaatagg
    26941 tctagtatat ttatttggaa atcaaggttt ggtaactaat ttacttggag tgcatgttcc
    27001 aatatatgga gcagtgggaa taatattggc acaaattata tatgtatttc ctcaatcatt
    27061 tcaaatactt tatatatctc taagttcaac cgattataga ctatatgaag ctagtaatac
    27121 tatggggata agcaagataa gagaatttat aagcataaca atcccaagta taaaatactc
    27181 tttaataagt tctgcattcg tatcgtttac attatgtttt acagattttg gagctccaaa
    27241 ggtgatagga ggagagttta atgtattatc aatagatgta tataagcaaa ttatagggca
    27301 acagaatatg ccaatgggag caactgtatc aatattactt ttaatacctg caataatatc
    27361 gtttatagta actaaaaaaa ttgaaaaaaa tcaaaattca tatataactt caaagtcaat
    27421 tccatataag gttaaaacta ataagttaag agatagtatt ttaggagggg ttgtaggaat
    27481 tattgcattt ggtataatag ctgtaatgtt aactgtaatc ttatcttcat taatatcagt
    27541 ttggccatat gatttaagac tgacactgga acatttttct atgaaaaaca gtattgatgg
    27601 gattaaacca tttataaatt caataaaaat gtcactattt acagctattc tagggacgag
    27661 ctttgttttc ttatttgcat atttgaatga aaaaacagaa aaagctccat atttaaaatc
    27721 atttgggtat tttttaagta cattgcctat ggcattgcca ggattagttt taggtatagc
    27781 ttatgtatta ttttttaata aattagagtt taattttatg gatacaatat acattaagaa
    27841 tttgtttaat ggattatatg gaacattact tataatggtt atatgtaata tagttcattt
    27901 cttttcagta gcatttataa cagctactac tgctattaag aaagtagata aagaattaga
    27961 tatggtagct aaatcaatgg gaataaacag cgcatcaatt cttaagaacg taactatacc
    28021 actttgtttg ccagcagttt tagagaactt tatgtacttt ttcctaaact ccatggtgac
    28081 aatatcagca ttagttttta tatatactgc aagttcaaaa gtagctgcaa tatcaattgt
    28141 acaactagat gataagggga gtactgcaca ggcagcagca ctagctgtgt taatattagt
    28201 cacaaatata ttagtgaaag taatatatga atttataaag aatcgtttag aaaaaagaac
    28261 aaactttaat taaataattt atcttataaa aacacaaatt taaaaaagtc tattcttgtg
    28321 atttattatt taaagaatag actttttaaa tttattattg atattgttta ttaattttcc
    28381 ttttgttatc atacatttga gaatctgcac gacgatatgt atcaaataaa gaaacatcta
    28441 ctttttcatc aaaaatagca tatccaatag acattgataa ttttaattca ttagttgagt
    28501 tttcttcaac t
//
LOCUS       DAEPID010000048        26986 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.048, whole genome shotgun sequence.
ACCESSION   DAEPID010000048 DAEPID010000000
VERSION     DAEPID010000048.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 26986)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 26986)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..26986
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.048"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            complement(<1..980)
                     /locus_tag="KR257_002389"
     CDS             complement(<1..980)
                     /locus_tag="KR257_002389"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893599.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="exonuclease domain-containing protein"
                     /protein_id="HBH0031072.1"
                     /translation="MKRVYIDFEMNMPNSKSKRAVFNSDIIAIGAVMYDEKTKNIDKF
                     KSLIRPVSNEELYPHIQELTHISSEELKSAPSYEEVMRKFKKWLGIFSDIKGIYTFGN
                     LDLTCFNNTDMRSAKKNNHPRFVNNIRDLFVDIKEKYINCGMRCMNYISLKNLLEFVN
                     LEFSGDAHDPLNDAYNLFILDEAITNNVDIQNLLIIRDIIRPPFNDINSNLDNCFNKF
                     KESLYKKEGNYNIVDFSVEIIKTVRMYLLTIIDVNIQNLEIMKDISKKMDTIDKLKDI
                     EEGYFYLLEDVYFDMKDVLEDLMLYRMNEDEYKYEIKNIIKMFDEDLDNE"
     gene            complement(1028..1888)
                     /locus_tag="KR257_002390"
     CDS             complement(1028..1888)
                     /locus_tag="KR257_002390"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011986089.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA 2-thiocytidine(32) synthetase TtcA"
                     /protein_id="HBH0031073.1"
                     /translation="MSELSGKGCEIIVPFEERLPVRDIEKSIIKKYRKNLWSKFMKAI
                     RDYKLVEEGDKIAVAISGGKDSILMAKMFQELKKHGQVNFDVEFIAMDPGYHANIRQL
                     LIDNCEYLNIPIHLFDSRIFEIADEIAKDYPCYMCARMRRGALYSKAEELGCNKLALG
                     HHYDDVIETTMLNLLCAGNFKTMLPKLNSTNFEGIKIIRPLYYIREEHIIRFIQNSGI
                     WPLNCACMVAAKKTGNKRYEIKDLIKSLESNFKNVEKSIFKAAENVNLDSVLGWQKDG
                     EKHSFLENFE"
     gene            2157..2366
                     /locus_tag="KR257_002391"
     CDS             2157..2366
                     /locus_tag="KR257_002391"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416732.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="spore coat associated protein CotJA"
                     /protein_id="HBH0031074.1"
                     /translation="MENKTRDIKKNCGPSLARPYINNQIFTEMYCLSDALKFGTIFPE
                     LNLLESEMYNKELYAKPKKYRGGRR"
     gene            2366..2632
                     /locus_tag="KR257_002392"
     CDS             2366..2632
                     /locus_tag="KR257_002392"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454698.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="spore coat protein CotJB"
                     /protein_id="HBH0031075.1"
                     /translation="MKDSSRAELMRKVQETSFACVDMNLYLDNHPDDKNAINTYNSLC
                     NQFAQARYAYENKYGPLTNFGYAPSRCPWQWADQPWPWDREFNY"
     gene            2661..3233
                     /locus_tag="KR257_002393"
     CDS             2661..3233
                     /locus_tag="KR257_002393"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000265278.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="manganese catalase family protein"
                     /protein_id="HBH0031076.1"
                     /translation="MWIYQKTIQHPVNIKTCDPRMAKFLITQFGGPNGELAASLRYLS
                     QRYTMPTGNMRALLTDIGTEELAHVELICTMVYQLTSDASPEELKAAGLGSNYAQNGY
                     GIYPTDSNGVPFDVRPIAVMSNPVTDLHEDMAAEQKALATYYQLINLTDDVDVIDVLK
                     FLGQREIIHYQRFGEALMDAYELEESQKMF"
     gene            complement(3468..4658)
                     /locus_tag="KR257_002394"
     CDS             complement(3468..4658)
                     /locus_tag="KR257_002394"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454699.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SH3 domain-containing protein"
                     /protein_id="HBH0031077.1"
                     /translation="MNFNQKRIAASIMATAIIMPTMGNLAYANESEVESVSIESRTIT
                     GNAVNFRKGPGTNHESMGKLYKGDKVEYVGKEGSWVKVKYNGNTGYVHGNYVAINSLG
                     SSNESSDTSVKSTKVVTAKGLNFRTGPSTSSSKISTLGYGTEVGYISESNGWSKISSN
                     GRVGYVSSKYLGTSVNDSTNENAENSSNDLVKGTKVVTAKSLNVRTGPGTSHSKIATL
                     SYGTEVGSISESGGWTKISYGNQTGYVSSQYLAEKGSVDTSIPSYSTNSPSQGADSVI
                     SFAKTLLGKPYVWGAEGPNSFDCSGFTQYVMKKSVGVSIPRVSRDQSKYGTYVNRGDL
                     RSGDLVFFDTQGSNNGSVSHVGIYIGNGDMIHASSGSSKKVTISNINSSYYSSRYVNA
                     RRVL"
     gene            complement(4918..5349)
                     /gene="dut"
                     /locus_tag="KR257_002395"
     CDS             complement(4918..5349)
                     /gene="dut"
                     /locus_tag="KR257_002395"
                     /EC_number="3.6.1.23"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454700.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dUTP diphosphatase"
                     /protein_id="HBH0031078.1"
                     /translation="MYNLKVKKLNDDAIIPNFAHKGDAGMDLYSIEEVVIPPGETKLI
                     KTGICIELPTMTEAQVRPRSGLALKHSVTVLNTPGTIDEGYRGELKIILINHGKNDFK
                     VEKHMKIAQMIVKPIYDINIEEVKELSDSERGKGGFGSTGF"
     gene            5462..7690
                     /locus_tag="KR257_002396"
     CDS             5462..7690
                     /locus_tag="KR257_002396"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861544.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type IA DNA topoisomerase"
                     /protein_id="HBH0031079.1"
                     /translation="MKLVLAEKPSVAKTIASFLGAKTRQDGYFEGNDYIITYAVGHLV
                     SLYDMKDYDKDKYSGSWKMNNFPFVPEDKFKFKIDSSKTKQFNTVKKLLNRKDVEYVI
                     NATDNDREGELIAFLIFLLAKNKKPVKRILVNEWTPEDITRGIKNLKDEDEMRNLQAA
                     GYTRLITDWLIGINFTSVATLKYGNGKLLNIGRVILPTVKLVYDRDMEILNFVPKTYY
                     EIEGHFKAEAGEYKGKYVKGKESKFDTLEDANKIIASITSETGKILDKKVTMSKEYAP
                     KLFSLTSLQGYITSKYSNFTSDKVLNVCQSLYEGNGKGGYITYPRTDSIFLEESLASK
                     ASQTLDKLKVGLEYENKIKFSKTKRVFDSSKVDSHSAIIPTYIIPKSLSKDEQLVYDA
                     IKDRFVANFMPPAEYENTEIKTEVDNCTFLTKGKVLKSKGYLEVYNKEEKNDLLPLVN
                     KDDVVDVLEIKPLTKQTTPPKPYTEDTLLKAMKNCGKNVPEEDTTVLSGYSIGTSATR
                     ADVLKKISQVGYVKKKGKSYSITDLGKNLVEIFPVKDLFDVDYTGKLEKSLSDIQKGK
                     YTRKEYLTNIISFIYQNVNIIKQDASKNINTEAYTFDSKTKKFTKTKEKKQKKDVTNT
                     EKEVAISKDSNNKKEVKNGDENQSLGKCPICQGDVLEFDKGFACKNHKECKFVIWKND
                     KYLSLYKKKVNKTMVKNILKKGETKVKSLTAKNGNKFDATLKYDKNPDTGYFNWKIEF
                     DN"
     gene            complement(7801..8286)
                     /locus_tag="KR257_002397"
     CDS             complement(7801..8286)
                     /locus_tag="KR257_002397"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454702.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MarR family transcriptional regulator"
                     /protein_id="HBH0031080.1"
                     /translation="MDNNNILKIADSFLDFLFVLENNIFKESDLLKKFQNNSDIMKAY
                     FEECPMAPSHAKVILYLMTSNSSSISQIASNLGILKSNMTPIIDRLVEHGLVNKFPDP
                     KDRRILRVELTDKAFKLFDAVKAILKESLVKKLSNLSEEELTLLDEHTLKLSEIVKKL
                     G"
     gene            8538..9761
                     /locus_tag="KR257_002398"
     CDS             8538..9761
                     /locus_tag="KR257_002398"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728791.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="efflux RND transporter periplasmic adaptor
                     subunit"
                     /protein_id="HBH0031081.1"
                     /translation="MKRYLIVFLMCSSLFLVGCGKTEESEPEKPIAVSVQKAIGGEIE
                     NTNSFSGTTKVKDETAVTAQTVGTVQEVYVKLGQNVRKGDELLSISSPELENSVKQSK
                     ASLDLAKASYSSATGGSLEAQVNQAKTALDNAKIQYEESQRNYDNNKILYEQEVISLD
                     QFKKIEFSLEQTKQQLDSAQRAYDTATSKSIPQAKALAKKQLDQAQVSYNLAMSNLDK
                     LTLTSPVDGTITAKNFDSKEMITQSQPAFIISNPNILEVDLNVAESDIGKFKKDGNVD
                     VIIEDQRILGKIDYVPSVVDPQTSLYPVKVLVNNTNNKFKAGMSAQVNLSVEKENGAV
                     TVPKKAIFEENGKKYVYIATKDNIAKKHLVQTGIVTEDKIEIKSGVSDKDTVIIGGIS
                     LISDGTKIFPVEKEK"
     gene            9765..12899
                     /locus_tag="KR257_002399"
     CDS             9765..12899
                     /locus_tag="KR257_002399"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416713.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="efflux RND transporter permease subunit"
                     /protein_id="HBH0031082.1"
                     /translation="MNLTQTSVKRPLTIIMVFLVLIVFGGIGYKKMSINLMPDIEIPV
                     VMVMTTWTGAGPQDVDEQVSQKVDESLSAVSNVKSTISSSQESVSMVVAQFEFGTNLD
                     EIMNDVRSKVDALQTSLPDDAAKPTVLKLDMNAQAIGQLVISGGNENSSQALRKYAED
                     VIQPKIESIDGVTSADLKGGEKAQVNVIADPAVLSNYGVSLSTIKGVLSSSNKTFPYG
                     SITQGEDKIVLRAIDKLESLDDIKQIQIPVKGGNTVRLDNLCSVDYGYADKDSIYRYN
                     GKDSLVIDISKQQDANTVKVMQSAYKYVDELNKENPQFKIKIANDTSSYISESINSVM
                     SNLLISAVIAFIVIFAFLKSVRASLVVAVAIPISIIGAIAILYFTGESLNLITASSLV
                     ISVGMVVDNATVVIENIFKYRKSGRLSLDDCAIEGTRTVTNAILASTLTTIAIFLPIM
                     FTEGIAKITFGALGKTLIASLAFSFIGAITLVPSVFAKLSRGKNSQKMQEKDSPIFDK
                     VSEAYKKLLSVCLRHQRLVVISSLLIFVASLFGMGFIGMDFMPAADKGELSISIELPK
                     GLSLESNDYYVSMTEKKVSDIPEIKTLITTLTSDSNNSKASIAIELESQKNRKRTTDE
                     IEKEIIDRVATVPDCKINVSQNSSVMGGAGGADFTLEMKGPDLDVLKILGKEAEKEFS
                     SIKGFRNVETSLTDTTQEAQFTIDKHKAQEYGVNTAEIAGMLRTAINGDSVTTATIDD
                     YKVDVNLKFKADTIDSLEDIKQLKVNSATGKEVPLGAFSDIKMADGLQSISRTDGDFS
                     VNITATLDNLDAGTATKLALEKTNKMVIPKDYSIGVGGETEMMNESMASLGFSMVIAI
                     ALVYMVMVAQFESFSKPFIIMFCVPFAFVGVVLSLLVSGQSLSTVGMLGIILLIGIVV
                     NNGIVLIDYIEQLRKTNRNNDLIGLVSIGCAARLRPVLMTTATTILGMLPTALSLGEG
                     GETMQPLAIVIMGGLTVSTLITLVLIPTIYLIFDKWENKFSDKMPKIFGKITDKIGSI
                     KRKIIKKPKLKAKV"
     gene            12933..14231
                     /locus_tag="KR257_002400"
     CDS             12933..14231
                     /locus_tag="KR257_002400"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012816284.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TolC family protein"
                     /protein_id="HBH0031083.1"
                     /translation="MSKIVAISCGVGIITANLIPVYADNNTSSINKVDNSILSDSNKR
                     TSEKEILTAREAVSAALKNSEKLKMKSEEIKMLKEKLEVQDEFDSFTGSDNSFPYDQI
                     GLLKNQSEQAKGFMEDQIANDITNKFNDLVSRENELDKIKNNLEIKTKEIKDMKLKKD
                     LGLVTSLETESAELELQTLQNTQKAKLQELKNNQDYFKLLTNIDLNNYQLDKEYRFES
                     FRVGGSVDSYMEGKVNEYLKYDQLILERTEESFNDKDENKADLPDRPNLTRPVAPTKP
                     EQGNLTDDEYKVLMDKYEKDYDRYKKEVEAYNLERQTYAAGLTTYANYLQQKFNTENG
                     LVTLEDSKKALKKGLIDSYAQLLALEDTIQITKKQLDLSEKQLKNTKLRYDLGLITLT
                     DYKKQVVSNEDAKNSYDTLIVNYNSLKNGIEKPWILNTGK"
     gene            complement(14520..14765)
                     /locus_tag="KR257_002401"
     CDS             complement(14520..14765)
                     /locus_tag="KR257_002401"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890610.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="zinc ribbon domain-containing protein"
                     /protein_id="HBH0031084.1"
                     /translation="MTKCPKCGKEVSSRPGSICPRCGFKVADESLKIRCPEPSCRALV
                     SRKLDYCPKCGCKLRGYNISEFVNMVRCKIDETFDKK"
     gene            complement(14979..17606)
                     /locus_tag="KR257_002402"
     CDS             complement(14979..17606)
                     /locus_tag="KR257_002402"
                     /EC_number="2.7.9.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861547.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pyruvate, phosphate dikinase"
                     /protein_id="HBH0031085.1"
                     /translation="METKYVYSFGEGSKDMKSLLGGKGANLAEMTKIGLPVPPGFTIT
                     TEACNDYYVNNESIRAEIIKEIEEHLATLEKDLNKTLGCNKNPLLVSVRSGAVFSMPG
                     MMDTILNLGLNDNSVVGLAEATQNERFAYDSYRRFIQMFSDVAMEVPKYKFENVLDRV
                     KEAKGYTVDTELTTDDLKEIVKEFKAIYKKEIKNDFPQDPKEQLMLAIEAVFRSWNNP
                     RAIVYRKLNDIAHNLGTAVNIQSMVFGNMGETSGTGVAFTRNPATGENKLFGEFLMNA
                     QGEDVVAGIRTPQNISTLADVMPAVFDEFVKITHILEGHYKDMQDIEFTIENERLYIL
                     QTRNGKRTAAAAINVAVDLVEAGIIDEKEAIMRIEPNQLDQLLHPKFEDKALKEAKVI
                     AKGLPASPGAASGKVYFNADDVVKANEKGEKVVLVRLETSPEDIEGMVKAEGILTARG
                     GMTSHAAVVARGMGKCCVAGCGEIKVDEFNKEIRALDDVVIKEGEYISIDGSTGNVYL
                     GDVKKTEVSLTGNFEKLMNWVDKHKCMMVRTNADNPRDARAAIEFGAEGIGLCRTEHM
                     FFDEARLPAVREMILSNTVEQREKALEKILPMQREDFVELFKVMDGKPVNIRLLDPPL
                     HEFLPHDDETIEELSKSMGIKVSDIKKRIVDLDEFNPMLGHRGCRLAITYPEICVMQS
                     KAIIQGAIEAIKAGVKVSPEIMVPLVGEVNELKIIRKMIVETVDAIIKEEGIEVPYTV
                     GTMIEIPRACLTADEIAQEADFFSFGTNDLTQMAFGYSRDDAGKFLGQYVDEEILEKD
                     PFQVLDQNGVGKLVKMGAKLGREVKPELKLGICGEHGGEPSSVEFCYSVGLNYVSCSP
                     FRVPIARLAAAQASIKNPR"
     gene            complement(17667..18509)
                     /locus_tag="KR257_002403"
     CDS             complement(17667..18509)
                     /locus_tag="KR257_002403"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454708.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="kinase/pyrophosphorylase"
                     /protein_id="HBH0031086.1"
                     /translation="MLVKNLIIYAVSDSVGETAQQVAKACMSQFYVNETYEIKRFPYM
                     INKGVLLETLENAKAENALIVYTLVDEELCSIVERYCEREGLSCIDLMTDILREISKR
                     TGRKPKREAGIIRKLDESYFKRVEAIEFAVKYDDGKDPRGVLQADIILVGISRTSKTP
                     LSMYLANKNIKVANVPLVPEIPIPKEVFEIDTKKIIGLTNSPEKLNEIRTQRLKALGL
                     SSKANYANLERILQELDYSEEIMKRIGCPVINVSNKAIEETAGIILDIMKENGLKIYK
                     EIEI"
     gene            complement(18516..19154)
                     /locus_tag="KR257_002404"
     CDS             complement(18516..19154)
                     /locus_tag="KR257_002404"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416703.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HBH0031087.1"
                     /translation="MIIIQLNERQLKIIDIVKENEPITSESIASSLNVTRATLRSDLA
                     ILTMTGILDARPKVGYFYSGVSEINLIGKSVKEKTVEDIMSMPVLAKKDESIYDVIVT
                     MFLSDVGSIVIIDENEELCGVVSRKDLLKATIGGSDINKMPIGMIMTRTPNVVTLTKG
                     ASVLLASRKIIEHEVDSIPIVEYKGEDKNHMRVVGRISKTNITKLFLEIVDN"
     gene            complement(19590..20882)
                     /locus_tag="KR257_002405"
     CDS             complement(19590..20882)
                     /locus_tag="KR257_002405"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454709.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NAD(P)-dependent oxidoreductase"
                     /protein_id="HBH0031088.1"
                     /translation="MLDLNRKLAKLEEEGKKIKVALIGAGHMGNGMVSQMANMKGIEA
                     SIVVDINLELAHKAFTDAGIDEEIIDNVTNEKDAEIKLQEGKVLTCNDFLVACKTKSI
                     DVVIDATGGIAIGAEIALNSILNKKHIVMLNAETDCVVGPILKKLADDAGVIFTGSAG
                     DEPGAVMELFDFADAMGFEVRVIGKGKNNKLDLDCNPDTVREEAERKGASPHMIASFK
                     EGTKTMVEMALMCNATGFVPDVRGGHGIEATVNEVPKKYALKSEGGVLDNYGVVDFVN
                     GIAPGVFVVVAHKLKAVNDELKYLSMGDGPNYILYRPYHLCSLETPLSAAMAVLDHKA
                     TIVPKAGLVAEVMTIAKKDLKKGEFMDGYGAYTCYGTIEKYDVAKAMNAVPIGLISKK
                     TKVVKDIKKGEVITYDMVEIEKDTTLYHLRQLQEKIFG"
     gene            complement(20919..21275)
                     /locus_tag="KR257_002406"
     CDS             complement(20919..21275)
                     /locus_tag="KR257_002406"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430855.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS glucitol/sorbitol transporter subunit IIA"
                     /protein_id="HBH0031089.1"
                     /translation="MKYEVKISGIGSLVKELMDESNCLIIYDETINDDDLKDISVIHS
                     IATLKSDVEIGDTLTIGNRDYCIVSVGDIAQKTLREIGHCTIKFDGKCEVNLPGEIHV
                     EIGNPDITIGDLITIS"
     gene            complement(21310..21669)
                     /locus_tag="KR257_002407"
     CDS             complement(21310..21669)
                     /locus_tag="KR257_002407"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897605.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0031090.1"
                     /translation="MKLLVILFVAYILNTIFIMKQNKLYFKTLNRAKKKGDIVSTGKK
                     KSYFSKGSIAIISSDSDGFIKFGEILKGRTVMAKFKEIEEIEGLDIYSAEQKFKDEES
                     IVQAIKFIKEKINVSFN"
     gene            complement(21738..23711)
                     /locus_tag="KR257_002408"
     CDS             complement(21738..23711)
                     /locus_tag="KR257_002408"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454714.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="BglG family transcription antiterminator"
                     /protein_id="HBH0031091.1"
                     /translation="MSVTEKIPSIDRKIFKILIMCSKKEFVSINSIANELNVTTRSVR
                     TYIKQLNKDLGNDIAVIKYIKGQGYKLEIKDEQILNKIIDMNRKNVFSLNSKEDRVEF
                     ILNYLIELDGFITLDSLADEMCVGRTTLVNDFQYVEKVLASYNLNLIKKQNTGMKLNG
                     NELDIRLFILNQLYKNSRKDFSNSKYFKGIKKEEIINLEEKLLTLFKKNNFYVTDEML
                     REVINYIVVLVYRVKEEKKVKDYDVKFDLLKSYDEYFIAREIKHIISGMFECTLNDEE
                     IIYLTIPLVSGNAPASECALNSSRISKNIDELMENIFNQIYVDMGIFINEDELRVGLG
                     YHLSFTLNRLLFNIKLKNVLLEEIKQNYILPFKLAQIAGKVIEKKYNLEVSEDEIGYI
                     AIHFSGYLERNSSRFYSIKKIAIICSTGLGTAKLLKIRVEKLIGNNPKIDTLSSFNLR
                     NINLDEYDIVFTTIDLDTSNINTIVLKINTIFDENKLREQLKTVLCLREGNIDTTNST
                     NLLINNLLDEDKFMILNEKTILASLEKMMDHLMDLGCIDDKFRKNIVNREEKSPTVFD
                     KGLLFPHSVNEKSDKFLMAVGILEEPIEYANRSIKIILMTMFPCENKIDSDLLVKIYE
                     EVLKIGQDVKLTNKISKCRTFLEFKKVLLKNLI"
     gene            complement(23933..24946)
                     /locus_tag="KR257_002409"
     CDS             complement(23933..24946)
                     /locus_tag="KR257_002409"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430861.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS glucitol/sorbitol transporter subunit IIB"
                     /protein_id="HBH0031092.1"
                     /translation="MEENKILKIEKGTSGWGGPLYIKKEGNRNKILSMTAGGIHEVTL
                     KIKELLGCEIVDGFKTGVSDEEVAVVIIDCGGTARCGVYPKKKIPTINVNPVGKTGPL
                     AKFITEEYYVSDVNPNCISVVDGEDMPQKSQENKSENKSSIRKPDNYDEVKSKAQGEY
                     AKKNIILSIGQGAGQVVSKFYDAGRDTIQMVMNNVIPFMAFVSMLMGIILASGLGDWI
                     ARVISPLAGNIGGLLIISVICTLPFLSPILGPGAVIAQVVGTLVGTQIGLGAIPAYLA
                     LPALFAINGQAGCDFVPVGLSLGEAEPETVEYGVPALFYSRLITGPIAVIIAYGVAVF
                     ALR"
     gene            complement(24959..25504)
                     /locus_tag="KR257_002410"
     CDS             complement(24959..25504)
                     /locus_tag="KR257_002410"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430863.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS glucitol/sorbitol transporter subunit IIC"
                     /protein_id="HBH0031093.1"
                     /translation="MENVITGLSKGAEWFIGLFQKGGEQFIGLVSGTLPTLIVLMVAI
                     NSLIKIIGEERVNNWASKLGKNSFTRYILLPLVSVFFLGNPMCYTFGRFLKEEHKAGF
                     YDAAVSFVHPITGLFPHANAGELFVWLGISAGLTTLGKETTTLALWYFIVGLIVIFIR
                     GIVTEKMYAFLTRKNRATNKA"
     gene            complement(25880..26749)
                     /locus_tag="KR257_002411"
     CDS             complement(25880..26749)
                     /locus_tag="KR257_002411"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861549.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AraC family transcriptional regulator"
                     /protein_id="HBH0031094.1"
                     /translation="MDYLKYFKKAVMYIENNLHENITVNDVAKETGYSYYHLTRLFKS
                     MFGESVGSYIKKRRLVSSTKELLYSDKKVIDIAIGSGFESSEAFSRAFKSIYKVSPIE
                     YRKNRIDVFVGKKKKLELDFMRHLVGNITIKPVIKEIEKIKVIGIKDKVILENNSLPD
                     LWEKFRKVHHIVPNTLPSKRVFGICEAISEIHLVSESMEFNEIIGLEVNSYDVIPNSF
                     VSKTIKEGKYAIFTHTGSLDNLDKTYEYIWGTWFLSSKEELDIRDDFEVYDERFLGPS
                     NVNSQIDIYIPIK"
BASE COUNT         9237 a         4479 c         3370 g         9900 t
ORIGIN      
        1 ttttcattat ctaagtcttc atcaaacatt tttattatat tttttatctc atacttgtac
       61 tcatcttcat tcattctata aagcattaaa tcttctagta catctttcat atcgaagtac
      121 acatcttcta ataaataaaa atagccttcc tctatatctt tcaatttatc tatagtatcc
      181 atttttttac ttatatcttt cataatttct aaattttgta tatttacatc tatgattgtt
      241 aataagtaca ttctcacagt ttttattatt tcaacagaaa aatctacaat attataattt
      301 ccttcttttt tatataatga ctccttaaat ttgttaaaac aattatctaa attagaattt
      361 atatcgttaa atggtggtct tattatgtca cgtattatta aaagattttg tatatctaca
      421 ttatttgtga ttgcctcatc caaaataaat aaattatatg catcatttaa tgggtcatgg
      481 gcatctccac taaactctaa gttaacaaat tcaagtaaat ttttcaatga tatatagttc
      541 atacatctca taccacaatt tatatatttt tcttttatat ctacaaataa atctctaatg
      601 ttatttacaa accttggatg gttatttttt ttagcacttc tcatatctgt gttattgaaa
      661 catgtcaaat ccaaattacc aaaagtatat attcctttaa tatcagaaaa tatgccaagc
      721 cattttttaa actttctcat gacctcttca taacttggtg cactcttcaa ttcttcagaa
      781 gatatatgtg ttaattcttg tatatgagga tacaactcct cattacttac tggtcttatt
      841 aaagatttaa atttatcaat attttttgtt ttttcatcat acataactgc tccgattgca
      901 attatatcag aattaaatac tgctcttttt gatttagaat ttggcatatt catttcaaaa
      961 tctatatata ctcttttcaa tataaacacc ctttccaatt gtttatagtg attcttttta
     1021 actattttta ttcaaaattt tctaagaaag aatgtttctc cccatctttt tgccaaccaa
     1081 gtactgaatc aagatttaca ttttctgccg ccttaaatat agatttttct acatttttaa
     1141 aatttgattc taagctcttt attaagtctt ttatctcata tcttttatta cctgtttttt
     1201 tagcagcaac catacatgca caatttaatg gccatatacc actattttga ataaatctta
     1261 taatatgttc ttctcttata taataaagtg gtcttataat ttttatacct tcaaaattag
     1321 tagaattaag tttaggaagc attgttttaa aatttccagc acacaataaa ttaagcattg
     1381 ttgtctctat tacatcgtca taatgatgac ctaatgcaag tttgttacac cctaattctt
     1441 ctgcctttga atataatgct cctctcctca ttcttgcaca catatagcat ggataatctt
     1501 ttgctatttc atctgctatc tcaaatatcc ttgaatcaaa taaatgtatt ggtatattta
     1561 gatactcaca attatctata agtaattgtc ttatatttgc atgatatcca gggtccatag
     1621 caataaattc aacatcaaaa ttaacttgtc catgtttttt taactcttga aacattttag
     1681 ccataagaat actgtctttt ccaccagaaa tcgctacagc tatcttatca ccttcttcaa
     1741 ccaatttata atctcttatt gccttcataa acttagacca taaatttttc ctatattttt
     1801 ttattatact tttttctata tctcttactg gaagtctttc ctcaaaagga actataattt
     1861 cacagccttt tcctgatagt tcactcatct aatcacctcg tatatttatg ttaataatat
     1921 tttacaaaaa agtctacctt catccacaaa atactataat ttttacttta attttactaa
     1981 ataatttata gtttacaata acacataaac ttataataac ataaataacc tctttctttt
     2041 attatctttt ttatttttct catttaatat tttattatta gtaacgattt ttaaatgatt
     2101 gaatattata cactagatag agttacctat ctatttacaa caaggaggtt ttcatcttgg
     2161 aaaataagac tagagatatc aaaaaaaatt gtggtccatc tttggctaga ccatacatta
     2221 ataatcaaat tttcacagaa atgtactgcc tttctgatgc attaaaattt ggaactatat
     2281 ttccagaact aaacttacta gagtctgaaa tgtacaacaa agaattatat gctaagccaa
     2341 aaaaatatag aggaggtaga agataatgaa agactcatct agagctgaac ttatgagaaa
     2401 agttcaggaa acatcttttg catgtgttga tatgaactta tatttagaca atcaccctga
     2461 tgataaaaat gctatcaaca cttataattc attatgtaat caatttgcgc aagctagata
     2521 tgcttacgaa aataaatacg gtcctttaac taactttggg tatgctccaa gtagatgccc
     2581 ttggcaatgg gctgaccaac cttggccttg ggacagagaa tttaattatt agacatcaag
     2641 tattggagga ttgaaaattc atgtggatat atcagaaaac tatacaacac ccagttaata
     2701 taaaaacttg tgaccctaga atggctaaat ttcttataac tcaatttggt gggccaaatg
     2761 gagaacttgc tgcatcttta agatatttaa gccaaagata tacaatgcct actggtaata
     2821 tgcgtgcact tttaacagat attggtacag aagaactagc tcacgttgag cttatatgta
     2881 ctatggttta tcagttaact tctgatgcaa gcccagaaga gttaaaagct gcaggtcttg
     2941 gttcaaacta tgctcaaaat ggatatggaa tttatccaac agattcaaat ggtgttccat
     3001 ttgatgtaag acctatagca gttatgtcaa atcccgtaac cgatttacat gaggatatgg
     3061 cagctgaaca aaaagcactt gcaacttatt atcaacttat aaacctaaca gatgacgttg
     3121 atgttataga tgtattaaaa ttcttgggtc aaagagaaat aattcattat caaagatttg
     3181 gtgaagcctt aatggatgct tacgagttag aagaatctca aaaaatgttc taaaattttt
     3241 atttgtataa ctattattat ttgataattt ataatttact gttgtgttaa aatttataaa
     3301 aaatataaat ataatttatt ttctataaac agagaaaata aataaaaagc aggtatcaat
     3361 caaatagtaa catgtattat actatacatt actatcaata ttgtacctgc tttcatatta
     3421 taagcaataa agaaaaatct atttattagg ttttataata aaaacaatta taaaactctt
     3481 cttgcattta catatctact tgaatagtag ctactattta tattagatat tgttactttt
     3541 tttgatgaac ctgaagatgc atgtatcata tctccatttc ctatgtatat tccaacatga
     3601 cttacagaac cattatttga accttgtgta tcaaagaata ctaaatctcc acttctaagg
     3661 tctcctctat ttacatatgt tccatactta ctttggtctc tagatactct tggtatacta
     3721 actcctacag attttttcat aacgtactgc gtgaatccag aacagtcaaa actatttgga
     3781 ccttctgctc cccatacata tggttttcca agtagtgtct ttgcaaaact tattacacta
     3841 tcagctcctt gacttggaga attagtcgaa taagatggaa ttgaagtatc aacagaacct
     3901 ttttcagcaa ggtattgact tgacacatat ccagtttgat tgccataact tatttttgtc
     3961 catcctccac tttcagaaat acttccaacc tcagtaccat aacttaatgt agctatttta
     4021 gaatgacttg tacctggtcc tgttctaacg ttcaatgact ttgctgttac aacctttgta
     4081 ccctttacaa ggtcatttga actgttttca gcattttcat ttgtagagtc atttacacta
     4141 gttcctaaat atttacttga aacataacct actctaccat tagaacttat ttttgaccat
     4201 ccatttgact cagatatgta tccgacttca gtcccatatc ctagtgttga tattttagaa
     4261 ctacttgtac ttggtcctgt tctaaaattt aatccttttg ctgttacaac ttttgtcgac
     4321 ttaactgaag tatcactact ttcattgcta cttccaaggc tatttattgc tacataattt
     4381 ccatgcacat aacctgtgtt tccattatat ttaactttta cccaagaacc ttcttttcct
     4441 acgtactcaa ctttatcacc tttgtaaagt ttccccattg attcatggtt tgtacctggt
     4501 ccttttctaa aatttaccgc attccctgtt attgttctgc tttctatact cacactctct
     4561 acttcagact cattagcata tgctaaattc cccatagtag gcattattat cgcagttgcc
     4621 attatactgg ctgctattct cttttgatta aaattcataa ctttccactc atctcctctt
     4681 ttctactatc tttatttcac ttcaaaatat aaaagaaata attgacacta tcaaaatatc
     4741 aattatttct tttatattaa tattattaca aatttgtaac tatttgtcta tagtaatatt
     4801 tgcttaccat aaattaccat gtataaattt taatctttaa tagcctgtaa tttagtaata
     4861 tagccatctt ttaccttttt taaaaatggc tatatttttt aacttttttg taacttttta
     4921 aaatccagtt gagccaaacc caccttttcc tctttcggag tcacttaatt cttttacttc
     4981 ttctatgtta atatcataga taggttttac tatcatttga gcaattttca tatgcttttc
     5041 aaccttaaaa tcatttttac catgatttat taatataatt ttaagctctc ctctgtatcc
     5101 ttcgtcaata gttcctggtg tatttaatac agtaacagaa tgctttaagg caagcccact
     5161 tctaggtctt acctgcgctt ctgtcatagt aggaagctct atacatatcc cagttttgat
     5221 aagtttagtc tctccaggag gtattacaac ctcttctata gaatacaaat ccataccagc
     5281 atcacctttg tgagcaaaat taggtattat agcatcatca tttaattttt ttacttttaa
     5341 attgtacatc ttatatctcc tttcaacttt ctataaatat tataacttaa atttcgacct
     5401 cttgaagttt tttatttttt tgtggtaata taattattag tgttttaaag gaggattttt
     5461 tatgaaactt gtacttgctg agaaaccatc tgtggcaaaa actatagcat catttttagg
     5521 tgcaaagacc agacaagatg gttactttga aggaaatgat tatataatta cttatgcagt
     5581 tggacactta gtatcattat atgatatgaa ggattatgat aaagataaat actctggctc
     5641 ttggaaaatg aacaatttcc catttgttcc tgaggataag tttaaattta agattgatag
     5701 ttctaaaact aaacaattca acactgtaaa aaagcttttg aatagaaaag atgtagaata
     5761 tgtaataaat gccactgata atgaccgaga aggagaactt atagcatttt taatattttt
     5821 actggcaaaa aataaaaaac cagtaaaaag aatcttggta aatgaatgga caccagaaga
     5881 tattacaaga ggtataaaaa acctaaaaga tgaagatgaa atgagaaatc ttcaagctgc
     5941 tggatatact aggcttatta ctgactggtt gattggaata aatttcactt ctgttgctac
     6001 attgaaatac ggaaatggga aactattaaa cataggtagg gtaattcttc caacagttaa
     6061 attagtctat gatagagata tggaaatact aaactttgtt cctaaaactt attatgaaat
     6121 agaagggcat tttaaagctg aagctggtga atataaaggt aaatatgtta agggtaaaga
     6181 aagtaaattt gatacacttg aagatgcaaa taaaattata gcttcaatta catctgaaac
     6241 tggtaaaata ctagataaaa aagttactat gtcaaaggaa tatgcaccaa aactttttag
     6301 tttgacatca cttcaaggat atataacttc taagtattcc aattttacat ctgataaggt
     6361 tttaaatgtc tgtcaatctc tctatgaggg taatggtaag ggtggataca taacttaccc
     6421 tagaactgat tccattttct tagaagaaag tttggcttca aaagcttctc aaactttaga
     6481 taaattaaag gttggtcttg aatatgaaaa taaaattaaa ttttctaaaa ctaaaagagt
     6541 ttttgattct tctaaagtag actcccatag tgctataatt ccaacttata taattccaaa
     6601 aagtttatct aaggatgaac aattagttta tgatgccata aaagatagat ttgtagcaaa
     6661 ctttatgcct cctgctgaat atgagaatac agaaattaag actgaagtag ataattgtac
     6721 tttcttaaca aaaggtaagg tgcttaaatc aaaaggatac cttgaggtat ataataagga
     6781 agaaaaaaac gatttacttc cacttgtaaa taaagatgat gttgtagatg tgttagaaat
     6841 aaaaccatta actaagcaaa ctactccacc taaaccgtat actgaggaca cacttttaaa
     6901 ggctatgaaa aattgtggta aaaatgtgcc tgaagaagat acaacagtgc tatctggata
     6961 ttcgattgga acatcagcca cacgtgctga tgtgttaaag aagataagtc aagtgggcta
     7021 tgtaaagaaa aaaggtaaat cttattctat aacagacctt gggaaaaatt tagttgaaat
     7081 ttttcctgtt aaagacttat ttgatgtaga ttatactgga aaacttgaaa aaagtttaag
     7141 cgatattcaa aaaggaaagt atacaagaaa agaatatctt actaatatca ttagttttat
     7201 atatcaaaat gtcaatatta taaaacaaga tgcttcaaaa aatataaaca cagaagcata
     7261 tactttcgat tcaaaaacta aaaaatttac taaaacaaaa gaaaaaaaac agaaaaaaga
     7321 tgtaactaat actgaaaaag aagttgctat atcaaaggat tctaataaca aaaaagaagt
     7381 taaaaatggt gatgaaaatc aatctcttgg caaatgcccc atttgtcaag gtgatgtact
     7441 agaatttgac aaaggctttg cttgtaaaaa tcataaagaa tgtaaatttg ttatttggaa
     7501 aaatgataag tatttaagtc tttataaaaa gaaagttaac aaaacaatgg tcaaaaatat
     7561 tttaaaaaaa ggtgaaacta aagtaaaatc tttaactgct aaaaacggta ataaatttga
     7621 tgctacatta aaatatgata aaaatccaga tactggctat ttcaattgga aaatagagtt
     7681 tgacaactaa atattcataa gaaaagaaat agcagtagta taataatcta tattatatta
     7741 ctgctatttc ttttcttatg aagtttcaac ttttttaata gtgactttta caatcacact
     7801 ctaacctaat ttctttacta tttctgataa ctttaatgta tgttcatcta ataaagttag
     7861 ttcctcttca gaaagattag ataatttttt tactagagat tctttgagaa tagcttttac
     7921 tgcatcaaat aatttaaatg ctttatctgt taattcaacc ctaagaatcc ttctatcttt
     7981 tgggtcagga aatttattga ctaaaccatg ttccactaat ctgtcaataa tcggagtcat
     8041 atttgatttt aaaattccta aattagaagc tatttgagaa attgatgatg aatttgatgt
     8101 cataagataa agaattacct tagcatgtga tggagccatt ggacattctt caaaataagc
     8161 tttcattata tcagagttat tttgaaactt ttttaacaaa tcgctttctt taaatatatt
     8221 attttcaagc acaaataaaa aatctaaaaa agagtccgct attttaagta tattgttgtt
     8281 atccatattt gtaacatccc ttcaatagat aatataataa aacattgttg tttaatatag
     8341 tataaattat aaactattaa taaatttaaa acaagaaaaa gttattgact cataataatt
     8401 ataaatttat aatcaaatta gagaattata aattgccaat aaagggaagt tttttaatta
     8461 gtctaaaact aaacttaaat tataagacac tttaaattct acaacaagct agtgtgcaat
     8521 atataatagg aggagatatg aaaagatatt taatagtttt cttaatgtgt agttcactgt
     8581 ttttagttgg atgtggaaaa acagaagaat ctgaacctga gaaaccaata gcagtttctg
     8641 ttcaaaaagc aataggtgga gaaattgaaa acacaaattc tttctcagga actacaaagg
     8701 ttaaagatga aacagctgtt actgcacaga ctgttggcac agttcaagaa gtgtatgtaa
     8761 aacttgggca aaatgtaaga aaaggagatg aattattgag tataagcagt ccagagctag
     8821 aaaatagtgt aaagcaaagt aaagcctcac tagatttagc aaaagcaagt tattcaagtg
     8881 ccactggtgg ttcattagag gcacaagtaa atcaggcaaa aacagctctt gacaatgcaa
     8941 agattcaata tgaggagtct caaagaaatt atgacaataa taagattctt tatgaacagg
     9001 aagtcattag tttagaccaa tttaaaaaaa tagaattttc tttagagcaa acaaaacaac
     9061 agttagattc tgctcaaaga gcatacgata cagcaacttc aaaaagtata cctcaagcta
     9121 aagcacttgc taaaaaacag cttgaccaag ctcaagtatc atataattta gcaatgagta
     9181 atttagacaa attaacatta acatctccag tagatggtac aataacagct aaaaactttg
     9241 attcaaagga aatgataaca caatcacaac cagcttttat tatttctaat cctaatatac
     9301 tagaagttga tttaaatgta gcagaatcag atataggtaa atttaagaaa gatggaaatg
     9361 tagatgttat aattgaagac caaaggattt taggaaaaat agattatgta ccttcagtag
     9421 ttgaccctca gacatcttta tatcctgtta aagtacttgt aaataataca aacaacaaat
     9481 ttaaggcagg tatgtctgct caagtaaact taagtgttga aaaagaaaat ggtgctgtta
     9541 cagtacctaa aaaagcaata tttgaagaaa atggtaaaaa atatgtatac atagcaacaa
     9601 aagacaatat agcaaagaaa cacttggttc aaactggaat tgtaacagag gataaaatag
     9661 aaattaaaag tggtgtaagt gataaagata cagtgattat cggagggata agtcttattt
     9721 ctgacggaac taagatattt cctgtagaaa aggagaagta gactatgaat ttaacacaga
     9781 cttccgttaa acgtcctctc acaatcataa tggtcttttt agtattaata gtttttggtg
     9841 gtattggata taaaaaaatg tcaataaatc taatgcctga tatagaaata ccagttgtaa
     9901 tggtcatgac tacttggaca ggtgctggtc ctcaagacgt tgatgaacaa gttagtcaaa
     9961 aagttgatga aagtttatct gccgtttcaa atgtaaaatc tactatatca agttcacaag
    10021 aaagtgtttc tatggtagtt gctcagtttg aatttggaac taatttggat gaaataatga
    10081 atgatgttag gtctaaagtt gatgcattac agaccagcct cccagatgat gcagctaaac
    10141 caacagtttt aaagctggat atgaatgcac aggctatagg tcaacttgtc atatctggag
    10201 gaaatgaaaa tagttcacaa gccttaagaa aatacgctga agatgtaatt cagcctaaaa
    10261 tagaatccat agatggtgtt acttcagcag accttaaagg tggagaaaaa gcacaggtta
    10321 atgtaatagc tgacccagct gttctttcaa attatggagt tagtttatcc actataaaag
    10381 gtgtcttatc ctctagtaat aaaacattcc cttatggttc aattactcaa ggtgaggata
    10441 aaatagtttt aagagcgatt gataaattag aatccctaga tgatataaaa cagattcaaa
    10501 ttcctgtaaa aggaggaaat acagttagat tagataatct ttgtagtgta gattatggat
    10561 atgcagacaa agatagtatt tatagataca atggaaaaga cagtttggta atagatattt
    10621 ctaaacaaca agatgccaac actgtaaaag ttatgcagag tgcatacaaa tacgtagatg
    10681 aattgaataa ggaaaatcct caatttaaaa ttaaaattgc taatgataca agttcataca
    10741 taagtgaatc aataaacagt gtaatgagca acttgcttat aagtgctgtt atcgcattta
    10801 ttgtaatatt tgctttccta aaaagtgtaa gagcttcact agttgttgca gttgcaatac
    10861 caatttctat aataggtgct atagcaattc tctactttac tggtgaaagt ttaaatctta
    10921 ttactgcaag ttcattggta atttcagttg gtatggttgt tgataatgct acagttgtaa
    10981 ttgaaaatat atttaaatat aggaaaagtg gtagattgag tcttgatgat tgtgctattg
    11041 agggaacaag aactgtaaca aatgcaatac ttgcatcaac attgaccaca atagcaatat
    11101 tcttacctat catgtttaca gaaggtatag ctaaaataac ttttggggca ttaggtaaaa
    11161 cactaatagc ttcactagca ttctccttta taggtgcaat tacactcgtt cctagtgtat
    11221 ttgcaaaatt aagcagagga aaaaatagtc aaaagatgca agaaaaagat agtcctatat
    11281 ttgataaggt aagtgaagca tataaaaaat tattaagtgt atgtttgaga catcaacgct
    11341 tagttgtaat atcaagttta cttatttttg tagcttcctt atttggaatg ggatttatag
    11401 gtatggactt tatgcctgca gcagacaagg gtgaattatc tatttctata gaacttccaa
    11461 aaggtcttag cctagaatcc aatgattact atgtatctat gactgagaaa aaagtctcag
    11521 atattccaga aattaaaact ttaataacaa ctttgacatc agattcaaat aatagtaaag
    11581 caagtatagc aattgaatta gaatctcaaa aaaatagaaa aagaactact gatgaaatag
    11641 aaaaagagat aattgataga gtggctactg taccagattg taaaataaat gtaagtcaaa
    11701 acagtagtgt tatgggtgga gctggaggag cagacttcac attagaaatg aaaggtcctg
    11761 atttagatgt attaaaaata ctgggaaaag aagctgaaaa agaatttagc tctataaaag
    11821 gatttagaaa tgttgaaact tctcttacag atacaacaca agaagctcaa tttactatag
    11881 ataaacataa ggctcaagaa tatggtgtaa ataccgctga aattgcaggc atgttacgta
    11941 cagcaataaa tggtgactcc gtaaccactg ctactattga tgattacaaa gtggatgtaa
    12001 acctaaaatt taaagcagat actattgata gcttagaaga tataaagcaa ctaaaagtaa
    12061 actctgcaac tggaaaagaa gttcctcttg gtgccttttc agatataaaa atggcagatg
    12121 gtctacaatc tatatctagg actgatggag atttttctgt aaatataact gctacacttg
    12181 acaatttaga tgctggtact gctacaaaac tagcactaga aaaaacgaat aaaatggtaa
    12241 ttcctaaaga ttactctata ggtgttggtg gtgaaacaga aatgatgaat gaatctatgg
    12301 caagtcttgg attttcaatg gtcatagcta tagcattagt ttatatggta atggtagctc
    12361 agtttgaatc atttagtaaa ccatttataa tcatgttctg tgttccattt gcattcgttg
    12421 gagttgtgct ttcgcttcta gttagtggtc aaagtttaag tactgtcggt atgctaggta
    12481 taatcttact tatcggtatt gttgttaata atggtatagt tcttattgac tacatagagc
    12541 aacttagaaa aacaaatcgt aacaatgatt taattggttt ggtttcaatt ggttgtgcag
    12601 caagattaag accagtctta atgactacag caacaacaat tttaggtatg ttgccaacag
    12661 cactatctct tggtgaaggt ggagaaacta tgcaaccact agccatagtt ataatgggtg
    12721 gtctaactgt atctacactt ataactttgg tgcttatacc tactatatac ttaatatttg
    12781 ataaatggga aaataagttt tcagacaaaa tgcctaaaat atttggtaag ataacagata
    12841 aaataggaag tataaaacgt aaaataataa agaaaccaaa attgaaagct aaagtttaaa
    12901 tagaatggag ggtgattgta ttgaataaaa aaatgagcaa aatagttgca attagctgtg
    12961 gtgttggtat aataactgcc aatttaatcc cagtttacgc agataataat acttcttcta
    13021 taaacaaagt tgataattct attttaagtg actcaaataa aagaacatct gaaaaggaaa
    13081 ttttgactgc tagagaagct gttagtgctg cacttaaaaa tagtgaaaaa ttaaaaatga
    13141 aatcagaaga aataaaaatg ttaaaagaaa agttagaagt acaagatgag tttgatagtt
    13201 ttactggaag tgacaactcg tttccatacg accaaattgg acttcttaaa aatcaaagtg
    13261 aacaggctaa aggctttatg gaggaccaaa tagcaaatga tattactaat aaatttaacg
    13321 atttagtttc aagagaaaat gagctagata aaataaaaaa caatcttgaa ataaaaacta
    13381 aagaaattaa agatatgaaa ttaaaaaaag atttagggtt agtaacatct ttagaaactg
    13441 aatcagctga acttgaactt caaacactac aaaatactca aaaagctaaa cttcaagaac
    13501 taaaaaacaa tcaagactat tttaagttat taactaatat agatttaaat aattatcaat
    13561 tggataaaga atatagattt gaatctttta gagtaggtgg ctcagttgat tcatatatgg
    13621 aaggtaaggt taatgaatat ttaaaatacg accaattgat tttagaacgt acagaagaaa
    13681 gctttaatga taaagatgag aacaaagcag atttaccaga tagacctaac cttacaagac
    13741 cagttgctcc tacaaaacca gagcaaggta acctaactga tgatgaatac aaggttctta
    13801 tggataagta tgaaaaagat tatgatagat ataaaaaaga agttgaagca tacaatcttg
    13861 aaagacagac ttatgctgct ggccttacta cttatgcaaa ttatcttcaa caaaaattta
    13921 atactgaaaa tggtctagta acattagaag acagtaaaaa agctcttaaa aaagggttaa
    13981 ttgatagcta tgctcaatta cttgctttag aagatacaat tcagattact aaaaaacaac
    14041 ttgatttatc agaaaaacaa ttaaaaaata ctaaattaag atatgattta ggattaatta
    14101 ctctaactga ttataaaaaa caagtggtaa gtaatgaaga tgctaaaaat agctatgaca
    14161 ctcttattgt gaattataac tcactaaaaa atggtataga aaaaccttgg atacttaata
    14221 ctggaaaata attctggtaa atagaaagat tactttaaca tacgtttgat taaaaaatag
    14281 ttatgcatac tcgtggcttt agtcatggaa gattcagaag gcaaataata gaaatagatt
    14341 agtaaaaata tatttactta taaaactgta tacttttata gaggctatct caaaatagag
    14401 ataagcctct tttttattgt ttaaattata aaaatatatt tgattccata caaaaagagt
    14461 gccttctgaa ctaaaaagtt cattttgaga caccctcaaa agcttaactc taaatttaat
    14521 tattttttat caaatgtttc atctatttta catctcacca tgttaacaaa ttcagaaata
    14581 ttatatcctc taagtttgca tccacattta ggacaataat ccagtttcct agataccaaa
    14641 gccctacaac taggttctgg acatcttatt tttagactct catctgctac tttaaatcca
    14701 catcgtgggc atatactacc tggacgtgat gatacttcct ttccacattt aggacacttt
    14761 gtcaacttta tcccctccag taaactcaat ttaattgata gttgaaattt ctctctacaa
    14821 taatatatgc aatataatta aatacgtttc acttacaact atataagtta aatttttata
    14881 ataaaaatcc cctatattca atttacaaat acttaatttg atacattgaa caatagggga
    14941 ttttattttt atttagttac atattttgca gtctattatt atctaggatt ttttatagat
    15001 gcttgagctg ctgcaagtct agcaattggc actctaaatg gtgaacaaga tacatagtta
    15061 agtcctacac tataacagaa ctctactgaa gatggttctc ctccatgctc tccacatatt
    15121 cctagtttta attctggttt aacttctcta cctaatttag ctcccatctt aactaactta
    15181 ccaacaccat tttggtctag tacttggaat gggtcttttt ctaatatttc ttcatctaca
    15241 tattgaccta agaatttacc agcatcatct cttgaatatc caaatgccat ttgagttaag
    15301 tcattagtac caaaactgaa gaagtctgct tcttgtgcta tttcatcagc agttaaacaa
    15361 gctctaggta tttctatcat agtacctaca gtataaggaa cttctatacc ttcttctttt
    15421 attatagcgt caacagtttc tactatcatt tttcttatta tttttaactc atttacttct
    15481 ccaactaatg gaaccattat ctctggagaa actttaacac ctgctttgat tgcttctata
    15541 gcaccttgta ttatagcttt agattgcatt acacatattt caggataagt tattgcaagt
    15601 ctacaacctc tgtgtccaag cattgggtta aactcatcta aatcaactat tctcttctta
    15661 atatcactta cttttattcc catagatttt gaaagttctt ctatagtctc atcatcatga
    15721 ggcaaaaatt catgtagtgg tgggtctagt aatcttatat taactggttt tccatccata
    15781 actttaaata actctacaaa atcctctctt tgcattggta atattttttc aagagctttt
    15841 tctctttgtt ctactgtatt agataatatc atttctctaa ctgctggcaa tctagcttca
    15901 tcaaagaaca tatgctcagt tctacataga cctatacctt ctgcaccaaa ctctatagct
    15961 gcacgagcat ctctaggatt atctgcatta gttctaacca tcatacattt gtgtttgtct
    16021 acccagttca ttaatttttc aaaatttcca gttaaagata cttctgtttt cttaacatct
    16081 cctaggtaca catttcctgt agaaccatct atagaaatgt attctccttc ttttataact
    16141 acatcatcaa gtgctcttat ttctttatta aactcatcaa cttttatttc tccacatcca
    16201 gcaacacaac atttacccat acctctagca acaactgctg catgtgacgt cattccacct
    16261 ctagctgtaa ggattccttc tgctttaacc attccttcta tatcttctgg agatgtctct
    16321 agtctaacta aaactacttt ttctcctttt tcatttgctt ttactacatc atcagcattg
    16381 aaataaactt taccacttgc tgcacctggt gatgctggta aaccttttgc tataaccttg
    16441 gcttctttta atgccttatc ttcaaatttt ggatgtaata attggtctaa ttgattaggc
    16501 tcaattctca tgatagcctc tttttcatca attattccag cttcaactaa atcaaccgct
    16561 acatttattg ctgctgctgc tgttctctta ccatttctag tttgtagtat atataatctt
    16621 tcattttcta tagtaaactc tatatcttgc atatctttat aatgaccttc aagtatatga
    16681 gtaattttta caaattcatc gaatacagct ggcattacat ctgcaagagt tgatatattt
    16741 tgaggagttc ttatacctgc aacaacgtct tcaccttgtg cattcattaa aaattcacca
    16801 aataatttat tttctcctgt agctggattt ctagtaaatg caacacctgt accactagtt
    16861 tctcccatat taccaaatac cattgattga atatttactg ctgttcctaa gttatgagct
    16921 atatcattca atttacggta tacgattgca cgaggattat tccatgatct aaatacagcc
    16981 tctattgcaa gcattaattg ctcttttggg tcttgtggga aatcattttt tatttctttt
    17041 ttataaattg ctttaaattc ttttactatt tcttttaaat catcagttgt aagttctgta
    17101 tcaactgtgt atccctttgc ttcttttact ctgtctaata cattttcaaa tttatatttt
    17161 ggaacttcca tagcaacatc agaaaacatt tgtatgaatc ttctgtaact atcatatgca
    17221 aatctttcat tttgtgtagc ctctgctaag ccaacaacac tattgtcatt aagacctagg
    17281 ttaagaattg tatccatcat tcctggcata gagaatactg caccagaacg aactgatact
    17341 aataatggat tcttattgca tcctaatgtt ttatttaagt ctttttctaa agtagctaaa
    17401 tgctcttcta tttcttttat tatctctgct cttatacttt cattgttaac ataataatca
    17461 ttacatgctt ctgttgttat agtgaatcca ggagggacag gtaagcctat cttagtcatt
    17521 tctgctaaat tggcaccttt acctcctagt aaagatttca tgtctttgct tccttcacca
    17581 aaactataaa catacttagt ttccattgtt aaatccccca ttaatctttt tattttaatt
    17641 tatatcattt ttattaatag acattattaa atttctattt ctttgtatat ctttagacca
    17701 ttttctttca ttatgtctaa aattatacct gctgtttctt ctattgcctt atttgaaacg
    17761 tttattactg ggcatccaat tcttttcatt atctcttctg aataatctaa ctcctgaagt
    17821 attctttcta aattagcgta gtttgcttta ctggacaatc ctaaagcttt taatctttgg
    17881 gttcttatct cattcagctt ttcaggtgaa ttagtaagac ctattatttt tttagtatct
    17941 atctcaaaca cttctttagg aattggtatt tctggaacta atggaacatt agctactttt
    18001 atatttttat tagctaaata catactcaaa ggagttttag atgttcttga tattcccact
    18061 aaaattatgt ctgcttgaag aacacctcta gggtcttttc catcatcata tttcactgca
    18121 aattctatag cttcaactct cttaaagtaa gattcatcta attttctaat tataccagct
    18181 tctcttttag gttttcttcc tgttctcttg cttatttctc ttagtatatc tgtcattaaa
    18241 tctatacaac taagaccttc tctttcgcaa tatctttcaa caatactgca taattcttca
    18301 tcaactaatg tatatacaat taaagcgttt tcagcttttg cattctccaa agtttcaagt
    18361 agtactcctt tattaatcat gtatggaaat ctttttattt cataagtttc attcacataa
    18421 aactgagaca tacatgcctt tgcaacttgt tgtgcagtct cccctactga atctgatact
    18481 gcatatataa ttaggttttt caccagcata cctccttaat tgtcaactat ttctaagaat
    18541 agcttagtta tgttggtttt tgatattctc ccaacaactc tcatatgatt tttgtcttct
    18601 cccttatatt caacaatcgg aatcgaatct acttcatgtt ctattatttt tcttgaagct
    18661 aataaaacac ttgctccttt agttaaagtg actacatttg gagttcttgt cattatcata
    18721 cctattggca ttttatttat atcagaacct cctatagttg cttttagcaa gtcttttctg
    18781 gaaacaactc cacataactc ttcattctca tctataataa ctatactccc tacatcagat
    18841 aaaaacatag tgactattac atcatatata ctttcatcct tcttagctag tacaggcatg
    18901 ctcattatat cctctactgt tttttctttt acacttttac caattaaatt tatttcacta
    18961 actcctgaat aaaaatatcc aacttttggt cttgcgtcta atattcctgt cattgttaat
    19021 atagctaaat cagatctaag tgtagcacga gtcacattca agctggaggc aatactttca
    19081 ctcgttattg gttcattttc cttaactata tctataattt ttagttgtct ttcattaagc
    19141 tgaataataa tcaccttctt tcattgtgct atacttttta tcttttcgca tcttatatag
    19201 tatattatat aactatatat accattctgt aaacagattt tttattgaat acgatatatt
    19261 ttttactaag ttctctcgct taaagatatt tattatatat taatggggga tatttcttta
    19321 attaatagaa ctatattagt attacagtta atattataat acataattgg tcattttaat
    19381 tcattttata ttaaaatttt taataatatt atttcaatgt gaatataaaa ttgcagaact
    19441 aattcaaaat aatttttacg actacaaata acctataata tacttttaaa gaaagtatcc
    19501 taacaagaat atataaaaat ttaaaagggt tgatttaaaa ataaccatca acccttttta
    19561 ctaatatcta tttatattac catcaaatct tacccaaata ttttttcttg caattgtctt
    19621 aaatgatata aagtagtatc tttttctatc tctaccatat cgtaagttat aacttcacct
    19681 tttttaatat cttttacaac tttagtcttt ttacttatca aaccaatagg tacagcattc
    19741 atagcctttg ctacatcgta tttttctata gtaccatagc atgtatatgc tccatagcca
    19801 tccataaact cacctttttt caaatctttc ttagctatag tcataacttc tgctactagt
    19861 ccagctttag gtactattgt agccttatgg tctaagactg ccatagctgc tgataaagga
    19921 gtctctaaac tacataaatg atatggtcta tataatatgt aattaggtcc atcacccata
    19981 cttaaatatt ttagttcatc attaactgct tttaatttat gggctactac tacgaaaact
    20041 ccaggtgcta taccatttac aaaatcaact acaccataat tatctaatac tccaccttcg
    20101 ctttttaatg catatttctt aggtacttca ttaactgtag cttcaatacc atgaccacct
    20161 cttacatcag gcacaaatcc agttgcatta cacattaaag ccatttctac cattgtttta
    20221 gttccttctt taaaagaagc tatcatatga ggtgaagctc cttttctttc tgcttcttct
    20281 ctaactgtat caggattaca atctaaatct aatttattat ttttaccttt acctatcact
    20341 ctaacttcaa accccattgc atctgcaaaa tcaaataatt ccattactgc acctggctca
    20401 tctcctgcag aacctgtaaa tattactcca gcatcatctg ctaatttttt aagtattggt
    20461 ccaacaacac aatcagtttc agcatttaac ataactatat gttttttatt taaaatagag
    20521 tttaatgcta tctctgcacc aattgcaata cctccagttg catctataac tacatctatt
    20581 gacttagttt tacaagccac aagaaaatca ttacatgtca atacttttcc ttcttgtaat
    20641 tttatttctg catccttttc atttgttaca ttatctataa tttcttcatc tattcctgca
    20701 tcagtaaaag ctttatgagc caactccaaa tttatatcta caacaataga agcttcaata
    20761 cctttcatat ttgccatttg gcttaccatt ccatttccca tatgcccagc tcctataaga
    20821 gctactttta tttttttacc ttcctcttcc aattttgcaa gttttctgtt taaatctaac
    20881 ataccaattc ctcctgttat aataatttta ttttcaaatt aagaaatagt tattaaatct
    20941 ccaatagtta tatctggatt tcctatttcc acatgtattt ctcctggtaa atttacttca
    21001 cattttccat caaatttgat tgtacaatgc ccaatttctc taagagtctt ctgagcaata
    21061 tcaccaactg aaactataca ataatctcta ttccctatag taagtgtatc tcctatttca
    21121 acatcacttt ttaacgttgc tattgaatga attacagata tatcctttaa gtcgtcatca
    21181 ttaatggttt catcatatat aataagacaa ttgctttcat ccattaactc tttaactaaa
    21241 ctgcctatcc cacttatctt aacttcatat ttcatgacat tcctcctgat aatttatatt
    21301 tatattgagt taattaaaag aaacatttat tttttctttt ataaatttta tagcttgtac
    21361 aatactctct tcatctttaa atttttgctc tgcactatat atatctaatc cttctatttc
    21421 ttcaatctct ttaaatttag ccattactgt acgtcctttt aaaatttctc caaactttat
    21481 aaacccatct gaatctgaag atataatggc tatacttcct ttagaaaaat agcttttctt
    21541 tttgcctgta gacactatat cacccttttt tttagctcta tttaaagttt taaaatacaa
    21601 tttattctgc ttcattataa atatagtatt taaaatataa gcaacaaata aaatcactaa
    21661 taatttcata tttatacacc ttccaaaaat cacattattt ttaaatctgt ataacaacta
    21721 taaatgctgt acaatagtta tataaggttt ttaagtaaca cctttttaaa ttctaaaaaa
    21781 gttctacatt tacttatctt attcgttaat tttacatctt ggcctatctt taaaacttct
    21841 tcataaattt ttactaataa gtctgagtct atcttattct cacatggaaa cattgtcata
    21901 agaattattt ttatacttct atttgcatat tctattggtt cttctaaaat tccaactgcc
    21961 attaaaaact tatctgattt ttcatttaca gaatgaggaa ataataaacc tttatcaaat
    22021 actgtgggag atttttcttc tctattgact atattttttc taaacttatc atcaatgcat
    22081 cctaaatcca taagatggtc catcattttt tctaatgaag caagtatagt cttttcattt
    22141 aatatcataa atttatcttc atctaacaaa ttatttatta gtaaatttgt agaattagta
    22201 gtgtcaatat tcccttctct taggcacaat actgttttta attgttctct tagtttgttt
    22261 tcatcaaata ttgtatttat ttttaatact attgtattta tatttgatgt gtctaaatca
    22321 atagttgtaa aaactatatc atattcatct aagttaatat ttctcaaatt aaaacttgaa
    22381 agagtatcaa ttttaggatt atttcctatc agtttttcta ctcttatttt caatagtttt
    22441 gctgttccta gacctgtact acatataatt gctatttttt ttattgaata gaatctactg
    22501 ctatttcttt ctaaatatcc actgaaatgg attgctatat atccaatctc atcttctgaa
    22561 acttctaagt tatacttttt ctctattact tttcctgcta tttgtgctaa tttaaatgga
    22621 agtatataat tttgcttaat ctcttctaac aaaacatttt ttaactttat attaaataat
    22681 agcctgttta aagtaaaact aagatgatat cctagaccta ctcttaattc atcctcattt
    22741 ataaaaatac ccatatcgac atatatttga ttaaatatat tttccatcaa ctcatcaatg
    22801 tttttactaa ttctactact atttaaagca cattctgatg ctggtgcatt tccactaact
    22861 aacggtatag ttaaataaat aatttcttca tcatttaaag tacattcaaa cattcctgat
    22921 attatatgtt ttatttccct agcaataaag tattcatcat atgatttaag taaatcaaac
    22981 tttacatcat aatcttttac tttcttttct tcttttactc tatagactaa aactactatg
    23041 tagttaataa cttctcttaa catttcatct gtaacataaa aattattttt tttaaataaa
    23101 gtcaatagtt tttcttctaa atttatgatt tcttcttttt tgattccttt aaaatacttt
    23161 gaattactga aatctttcct tgagttttta tacaactgat ttaatataaa cagtctaata
    23221 tcaagttcat ttccatttaa tttcatacct gtattctgtt ttttaatcaa gtttaaatta
    23281 tatgaagcca aaactttttc tacatactgg aaatcattta ctaaagtagt tcttcctaca
    23341 cacatctcat cagctaaact atcaagtgta ataaatccat ctagttctat caagtaattt
    23401 agtataaact ctactctatc ttcttttgaa tttaatgaaa atacattttt tctattcata
    23461 tcaataatct tattgagtat ctgctcatct tttatttcta gtttatagcc ttgacccttt
    23521 atatatttga ttactgctat atcattacct aaatctttat tcaattgttt tatatacgtc
    23581 cttacacttc tagttgtgac attcaattca tttgctattg agttaatact cacaaactct
    23641 tttttactac acataatcaa tatcttaaat atcttgcggt caatagaagg aattttctca
    23701 gttacactca ttttgtatct cctccttgat ttcattctag tacaaatttg aaaccaaatt
    23761 aatacataaa atttcacttt aataaaggaa aatttagtat taatctaact cgataattac
    23821 agctaattaa tagtataaaa gctagtcttt cattaacaaa aaatcttgac tagcttaaat
    23881 ttatatttac aattttatta attaattcca agccttatat tgacattaaa tattatctca
    23941 atgcaaatac tgcaactcca tatgcaataa taacagctat tggaccagtt attaaacgag
    24001 agtaaaataa agctggaaca ccatactcta cagtttctgg ttctgcttct cccaaactta
    24061 atcctactgg tacaaaatca catccagctt gcccatttat tgcaaataaa gctggaagtg
    24121 ctaaatatgc tggtattgca ccaagaccaa tttgtgtacc tacaagagtc cctactactt
    24181 gagctataac tgcaccaggt cctagtattg gtgataagaa tggaagtgtg caaattactg
    24241 atataatcaa taatccacca atattacctg caagtggaga tataactctt gcaatccagt
    24301 ctcccagtcc agatgctaaa ataattccca taagcatact tacaaatgcc ataaatggta
    24361 ttacgttatt cattaccatt tggatagtat ctcgacctgc atcataaaat tttgatacta
    24421 cttgccctgc cccttgacca atagaaagta ttatgttctt tttagcatat tcaccttgtg
    24481 cttttgactt aacctcatca taattatcag gctttctaat agaactctta ttttcgcttt
    24541 tattttcttg agatttttgt ggcatatctt ccccatctac aacacttata cagttaggat
    24601 taacatctga tacataatat tcttctgtta taaattttgc taaaggacct gtttttccaa
    24661 ctggatttac atttattgta ggtatttttt tctttggata aactccacat ctagcagttc
    24721 caccacaatc aataataact actgctactt cttcatcaga aactccagtt ttaaatccat
    24781 ctacaatttc acaacccagt agttctttta tttttaatgt tacttcatgg ataccaccag
    24841 cagtcattga cagtatctta tttctattcc cttctttttt tatatacaaa ggacctcccc
    24901 agcctgaagt tcccttttct atttttaata ttttattctc ctccatttta tctacctcct
    24961 aagccttatt tgttgctcta ttttttcttg ttagaaaagc atacattttt tctgttacta
    25021 tacctcttat aaaaattaca attagaccaa ctataaaata ccacaatgcc aatgtagtag
    25081 tttctttacc taaagtagtc aaacctgcag atattcccaa ccatacaaaa agttctcctg
    25141 catttgcatg tggaaaaaga cctgtaattg gatgtacaaa tgaaactgct gcatcataaa
    25201 atcctgcttt gtgctcttct tttaaaaatc taccaaatgt atagcacata ggatttccca
    25261 agaaaaatac tgatactaat ggaagtagaa tatatcttgt aaaagagttc tttcctagct
    25321 tagaagccca attattaact ctttcctcac caattatctt aatcaaagag ttaatagcta
    25381 ccattaatac aattagcgtt ggaagagtac ctgaaacaag acctataaat tgttctcccc
    25441 ctttctgaaa caaaccgata aaccactctg cacctttact tagacctgta ataacgtttt
    25501 ccataaaatt ataacctccc tataatatct ttaaattttt aattttactg cttaccataa
    25561 attttacaaa ttacatcttt tttctgtact atatgctaat attgtaaatg tttttttatt
    25621 aatatcattt taatataata tttttgataa ataaatacat cttttttcaa ttttataaag
    25681 gaaaaaattg tactaattag aattttcaga aatatacaat tcttatttcg actatattct
    25741 aaattcttct tagaaattta agaacttatt tttatttctt ttattattaa aattatctaa
    25801 atctgataaa aataaaaaat agatgctctt ttacgaacat ctatttctta atcaaattat
    25861 tttttagttt tcttatagat tattttatag gtatataaat atcaatttgt gagttcacat
    25921 tactaggacc taaaaatcgt tcatcatata cttcaaaatc atctcttata tcaagttctt
    25981 cttttgaact taaaaaccaa gtaccccata tatattcata agttttgtct aaattatcta
    26041 agctaccagt atgagtaaat atagcatact ttccttcctt aatagttttt gaaacaaatg
    26101 aatttggaat cacatcataa ctattaactt caagtcctat tatctcatta aattccatac
    26161 tttcactaac taggtgtatt tcagagattg cttcacagat tccaaaaact ctctttgatg
    26221 gcaaagtatt tgggacaata tgatgtactt ttctgaattt ctcccacaag tcaggtaatg
    26281 aattattttc taaaattact ttatccttta tacctattac ctttattttt tctatttctt
    26341 ttataactgg tttaatcgtt atatttccaa caagatgtct cataaaatct aactctaatt
    26401 ttttcttttt accaacaaat acatcaattc tattttttct atattctata gggctaacct
    26461 tgtatataga tttaaatgct ctgctaaatg cttccgaaga ttcaaatcca ctaccaatag
    26521 ctatatctat cactttttta tcactatata aaagttcttt tgtactactt actaatcgtc
    26581 ttttttttat ataacttcct acactctcac caaacataga cttaaataag cgtgttaaat
    26641 gataataaga atatccagtt tcttttgcca catcatttac agttatattt tcatgtaaat
    26701 tattctcaat atacattaca gcttttttaa aatactttaa gtaatccaat atggcacctc
    26761 tcttctactt aaactcttta aatatgtaaa atagcactat tttttactat actaaaatat
    26821 tataactaat tcaatacgat aaataaaaac ttttagttga tttatatatc ctaattattt
    26881 agaataatta aatacatttt ttattcaatg aaatcaaaaa agtcagatgg tgctttttca
    26941 atatttatgt ttatcctctg tgttatagat ttaatgtcat ttttta
//
LOCUS       DAEPID010000049        26366 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.049, whole genome shotgun sequence.
ACCESSION   DAEPID010000049 DAEPID010000000
VERSION     DAEPID010000049.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 26366)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 26366)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..26366
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.049"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            <1..287
                     /locus_tag="KR257_002412"
     CDS             <1..287
                     /locus_tag="KR257_002412"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454130.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=3
                     /transl_table=11
                     /product="accessory gene regulator B family protein"
                     /protein_id="HBH0031095.1"
                     /translation="NINIDLFKNIIMIIASVSWVGICVLCPIEHRSNPISDREKLVYK
                     KTAIFISTVVLLITILSLSLSIFVDYFTYSAFAMFWIFVMLVLGKLKAKV"
     gene            317..463
                     /locus_tag="KR257_002413"
     CDS             317..463
                     /locus_tag="KR257_002413"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426457.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cyclic lactone autoinducer peptide"
                     /protein_id="HBH0031096.1"
                     /translation="MKKFIVRFMKFASSLALSTAILSANSTCPWIIHQPKVPKEISNL
                     KKTN"
     gene            768..2147
                     /gene="scfB"
                     /locus_tag="KR257_002414"
     CDS             768..2147
                     /gene="scfB"
                     /locus_tag="KR257_002414"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728914.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="thioether cross-link-forming SCIFF peptide
                     maturase"
                     /protein_id="HBH0031097.1"
                     /translation="MSMIHKFSMNGYNIVLDVNGGAVHVLDDVAYDLLDFYKEKSKEE
                     ILEILKSKYQEEKINEAYEEILNLEKEGLLYTEDTYQYHPSFVHREPVVKALCLNVAH
                     DCNLKCKYCFAAQGDFGGEKELMSFEVGKAAIDYLIANSGSRKNLEIDFFGGEPLMNF
                     EVVKQLVDYGRSVEKDYNKNIRFTITTNGVLLNDEIIDYINENMHNVVLSLDGRKEVN
                     DNMRPTLNDKGSYDITLPRFKKLVEKRAKDKYYYIRGTFTRDNLDFSKDVMHFADLGF
                     KLTSVEPVVGDESNPYALREEDLPKIFEEYEKFAVEYADRQLQGDGFKFFHFMIDLNQ
                     GPCVIKRITGCGAGNEYLSVTPNGDIYPCHQFVGNEEFKMANIFDEEIVLPENLKNMF
                     REAHVYTKEECKQCWNKFYCSGGCHANAINFNNDISKPYELGCEMQRKRTECSIMIQA
                     KLMLEGATN"
     gene            2176..2673
                     /locus_tag="KR257_002415"
     CDS             2176..2673
                     /locus_tag="KR257_002415"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422909.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="gamma carbonic anhydrase family protein"
                     /protein_id="HBH0031098.1"
                     /translation="MIRDYLEDKPLIDESVFVAKSADVIGNVKIGKDSSIWYNAVVRG
                     DEGPITIGENTNIQDCSIVHGDTETIIGNNVTVGHRSIVHGCKISDNVLIGMGSIILD
                     NAEIGEYTLIGAGTLITSNKKFPPGVLIMGSPGKVVRELTEEDKKYIDESYEWYLEAA
                     QNQKY"
     gene            2971..4635
                     /locus_tag="KR257_002416"
     CDS             2971..4635
                     /locus_tag="KR257_002416"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891005.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AarF/ABC1/UbiB kinase family protein"
                     /protein_id="HBH0031099.1"
                     /translation="MRISYRNLKRYREIGYVLIKYGFSFIVERLNIEGIAYKIPLFDP
                     PEEIKNMTTGERMKRVLEELGPTYIKIGQILSTRKDLLDQDIIDEISKLRDDVEKFDS
                     NIAIDIFKEEVGLSIEEIFLEFKEEPIAAASIGQVYEGVLKTGEEVIVKIQRPNIEKI
                     IKSDLEILRTIANTLKDLKKDFNLDLVQMIEEFQTQLMRELDYTFEAINATKFSRIFK
                     NSDEVYIPKVYSEYNTKKILVMEKVNGTKLSDVEKIRRLGYNTKTIVEIGVRSFFTQV
                     LSHGFFHADPHPGNIFVVAKNKIAYIDFGMIGIIDNKTLNQLNEIALAGVEKNVDKII
                     YLLIEMDALNGEADIKGLRQDLLYLIHYYYDISIEKINVTDILNELFRFFRQYKIVMP
                     AQFVTLAKTVITLEGTSRTLNTDFSFGSMGKEFMKHHYKSKFNPKNVVLSSRQNVEEI
                     LLDIKTIPKQLKAILKNIERNNIKMQIEDVKMTRLENCIIELTSQISLSLVLASIIVG
                     SSLIIASPNIENNIWIKFTAIAGFFISFIIGLCLVIRSIRSKYKKD"
     gene            4648..7098
                     /gene="recJ"
                     /locus_tag="KR257_002417"
     CDS             4648..7098
                     /gene="recJ"
                     /locus_tag="KR257_002417"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422914.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="single-stranded-DNA-specific exonuclease RecJ"
                     /protein_id="HBH0031100.1"
                     /translation="MKKWILKYKGKIEESEFSKKLNISPEICQILKNRGICTEKDSEI
                     FMNPSLDYLRDPFLMKDMQKAVDRIKLAVEKNEKIWIYGDYDVDGVSSTSILCLYFKS
                     IGYNVDYYIPNRLEEGYGINEDAIKLISSRGCDLIISVDCGITSVSEVNTANDLGIDV
                     IITDHHECQSEIPSAFAVINPKQEDCNYPFDSLCGCGVAFKMIQALTPKEEFKTSMYN
                     YLEIVTLATICDIVPLIDENRIIVKNGLKSMKEGKNIGLRELIKVCGVESDKIGSSHI
                     GFAIGPRINASGRLGYSYLGVELFTTQSQEEAVEIASILEEKNNERQMIEAKMYHEAE
                     EMLKSNSRYNDDKVLVLAKEGWQHGIIGIVASKLTEKYYKPTILLGIENGEATGSARS
                     IKGFNIFEALIKCKDLMTKFGGHEQVAGLSLDSDNVEILANEINKFADYNLTEDDMIE
                     NVNVEFELQENVINLNLVEELHKLEPFGLNNPNPRFIVRNYILKDLKVIGKNQQHLKL
                     SIEKEKSYECIGFNMSHLKSMYKVGDKVDVLFQLDENNYMGNRKVQFLLKDIRLARPK
                     SASNDKLSLKLMSKIIPKDTQSLYNISVSDFELFDGNTDINIFDYFEKDTLIISNSIN
                     GFYRAMSDISLIDLDFNINYNIIEDDSKNTDKLELIFSPNIDKIDLKRYNNIILYDYL
                     YNKGEYSYIYENKREESEIIKYYNKTDLLYLKNVVSNIVPSRDEFITIYKQALIKKEI
                     DLDMVNIRETFNVIPLKFFTILNVFRELNLLDFNLNYEKNSVLIRILPKPQKKLDLNE
                     SLILNNLKNLEKQYNSSY"
     gene            7111..7623
                     /locus_tag="KR257_002418"
     CDS             7111..7623
                     /locus_tag="KR257_002418"
                     /EC_number="2.4.2.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426450.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="adenine phosphoribosyltransferase"
                     /protein_id="HBH0031101.1"
                     /translation="MDLKNFIRNIDDFPKPGIDFKDVTTLFKDGDAFKYAVDSIVEEL
                     KDKDVDLVIGPEARGFLMGTPVAYALGVGFVPIRKPGKLPGEVESYEYGLEYGTDTLE
                     IHKDAIKKGQKVAIVDDLLATGGTMEAAAKLVEKLGGEVVSMQFLIELKFLNGREKLS
                     NYDVNSLIKY"
     gene            7697..9904
                     /locus_tag="KR257_002419"
     CDS             7697..9904
                     /locus_tag="KR257_002419"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003229747.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional (p)ppGpp
                     synthetase/guanosine-3',5'-bis(diphosphate)
                     3'-pyrophosphohydrolase"
                     /protein_id="HBH0031102.1"
                     /translation="MHDKELQEIIEKIKVYAPNANFEMVEKAYNLAKKAHEGQYRKSG
                     EPYFIHPLAVANILIEMELDIETITAGLLHDVVEDTEYTYEDIKKEFGKEVADLVDGV
                     TKLGQIKYRSKEETQSENLRKMFLAMAKDIRVILIKLADRLHNMRTLKYMPPEKAKYK
                     AKETLEIYGGIAHRLGISKIKWELEDRALRFMDPEGYYDLVSRVSMKRSQREDYIQGI
                     VELLKDKFKDLSIPCDVYGRPKHFYSIYRKMQKKHKTFEEIFDLTAVRILVDNVKDCY
                     AVLGIVHTLWRPIPGRFKDYIAMPKPNMYQSLHTTVVGPDGEPLEIQIRTHEMHNIAE
                     NGIAAHWKYKEGISSKESKVEEKLQWLRQMMEWEKDLKDPQEFMDALKEDVFNSQVYV
                     FTPKGDVIELPAESTPIDFAYRVHTNVGNKCVGAKIDGRIVPIDYKLQNGNIVEVLTS
                     SNSNGPSRDWLNIVKTPNAKSRIRQFFKKERREENVDRGNTILEREFKKHDIPQKDPL
                     VEKYMALVAKKFNQPSVEDLIATVGYGGIMSSQVVSKVKDLYLKEVKKAKKEQQIQEE
                     DLNKHNISETEYSKKRKKNASQGIIVKGLDNILVRFAKCCNPLPGDEIVGYITKGRGV
                     AIHRADCPNANNNGDFFQNRLVEVSWSSAGKGKFEAEIQIKAIDRRGIVNEITHIVAM
                     DKLSLNGINARKGKDSIVSINLLVEVNDTEELKILMKKLKAIPGVESIYRMTN"
     gene            9929..10378
                     /locus_tag="KR257_002420"
     CDS             9929..10378
                     /locus_tag="KR257_002420"
                     /EC_number="3.1.1.96"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003517065.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="D-tyrosyl-tRNA(Tyr) deacylase"
                     /protein_id="HBH0031103.1"
                     /translation="MRAVVQRVSSSKVTVDENTIGQINKGLLVLLGVTHDDKSSDVDY
                     MIDKILNLRIFEDENDKMNLSLMDIGGELLVVSQFTLYGDCRKGRRPGFSNAARPELA
                     NNLYEEFVKKAKDKGVTVGTGQFAAHMMVELTNDGPVTILLDSSKSF"
     gene            10393..11007
                     /locus_tag="KR257_002421"
     CDS             10393..11007
                     /locus_tag="KR257_002421"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891001.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MBL fold metallo-hydrolase"
                     /protein_id="HBH0031104.1"
                     /translation="MIIKKFVDSYFGVNTYVLGDEKTKKCAVIDPGGSLVETLSFVKE
                     NELNIEYIILTHGHGDHIGYVKDIKEKTGAKVVAHVDEKELLNDKNKNLSYTMRCGAQ
                     EFDADIYVNDKDKLELGELKMTFLHTPGHTQGCMCIRVEDEMFTGDTLFAGSIGRTDL
                     YSGDFNQMEKSLKKLCKYEDAVRVYPGHGPTSTLGVEKKTNPYM"
     gene            11098..12654
                     /locus_tag="KR257_002422"
     CDS             11098..12654
                     /locus_tag="KR257_002422"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422926.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="coproporphyrinogen III oxidase"
                     /protein_id="HBH0031105.1"
                     /translation="MLYVFLKGHDYKYEVAELIKLFTSEFKFKDSNANNNIESKHLIN
                     RLIYENGVLFSSTEYYENGNLKYESIQNIENMNLEFLDGFDSSKTIEEFLNSLDSESK
                     RNFKKLCKENIKKSMFLVLKQVFNSYVPWGILTGIRPVKIVHNLMDKKLDDNSIRTIL
                     KDNYFIIDEKIDLALEIAKRERLFMYPIDKNKISLYVSIPFCPTRCVYCSFPSNSLKQ
                     FGHLKREYVYKLIEEIKGFAKVIKDTKKEVETLYIGGGTPTTLDEEELDLLINSLFNE
                     LDLSKIKEFTVEAGRPDTITEQKLRVLKKHNVSRISINPQTMNDDTLVKIGREHRVSD
                     LVDCFNMARRMGFDNINMDIILGLIDEDLNMVKNTLEEIKKLSPESLTVHTLAIKRAS
                     NLNINMDRYKEHLTQYEEMVKMIDLSMKYAKDMGLNPYYMYRQKHMLGNLENIGYAKE
                     GYECIYNIQIMEEKQSNYALGAGAISKFVYVDEDRIERVENVKNVEQYIERVDEMIKR
                     KKEEVYKNVD"
     gene            12644..13906
                     /locus_tag="KR257_002423"
     CDS             12644..13906
                     /locus_tag="KR257_002423"
                     /EC_number="6.1.1.21"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422928.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="histidine--tRNA ligase"
                     /protein_id="HBH0031106.1"
                     /translation="MLTKAPRGTKDITPKEAYKWRYVENKFREICALYGYEEMVTPIF
                     EHTELFKRSVGDTTDIVQKEMYSFKDKGDREITLKPEGTAGVVRAFIENKLYADTQPT
                     KLFYVTPCFRYERPQAGRQRQFHQFGIEALGSDTPSMDAEIIALAVQFFNEVGLNDLV
                     VSINSVGCPVCRKEYNALLKEYLDSKADILCDTCNERREKNPMRVIDCKNPTCKENIK
                     DIPFIADHLCDDCKSHFDKLQEYLKEMNINFVIDKTIVRGLDYYRKTAFEIISNDIGA
                     QSTVCGGGRYDGLVEQLGGPKGISGIGFGLGIERLLLTLEGNGIEIENPQSTDIFIVT
                     IGEEANTRSFKLLKDLRQNHISADKDHIERSVKAQFKYSDKINSKFTIVIGDDELKND
                     TATLKNMKTSEQTTVKLSTLVEELKQKL"
     gene            13980..15767
                     /gene="aspS"
                     /locus_tag="KR257_002424"
     CDS             13980..15767
                     /gene="aspS"
                     /locus_tag="KR257_002424"
                     /EC_number="6.1.1.12"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454140.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aspartate--tRNA ligase"
                     /protein_id="HBH0031107.1"
                     /translation="METLKGLKRTHYCGELREKNINEEVVLMGWVQKKRNLGGLVFVD
                     LRDTSGLCQIVFDTDVDKEAFEKAEKLGAEFVIAVKGKVCERQSKNPNMLTGDIEIFA
                     TELRLLNKSETPPIYIKDDDDVSEALRLKYRYLDLRKPSMQRNLKLRHKVMNITRNYL
                     SNNRFCEIETPFLIAPTPEGARDYLVPSRVNPGKFYALPQSPQLYKQLLMVSGMDRYF
                     QIVKCFRDEDLRADRQPEFTQIDCEMSFVEQEDVMSMIEGLLEAIFKEVLDVELALPL
                     PKMTYAEAMSKYGSDKPDTRFGYELTDISDVVCNCGFKVFADATQPGKSVRGINVKGK
                     ADDFTRKQISSLEEHAKTYRAKGLAWMKVGQEGVTSPIAKFFNEEEMNAILTRMNAEV
                     GDLLLFVADKNSIVFDALGQVRLEVANRLNLLDKNVYNLLWVTEFPVFEEDEETGTFS
                     AMHHPFTSPMDEDLDKLEEGDKSSLRAKAYDIVLNGYEIGGGSVRISNSDVQSRMFKA
                     LGFTEERANEKFGYLLEAFKYGTPPHAGLAFGLDRLVMLLAGTDNIREVIAFPKNQNA
                     VCPMTNAPTLAEDEQLEELSIKVDIKDNE"
     gene            16226..17458
                     /locus_tag="KR257_002425"
     CDS             16226..17458
                     /locus_tag="KR257_002425"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728912.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cytosine permease"
                     /protein_id="HBH0031108.1"
                     /translation="MQEREELVLNPVPKEERVGWLAPLFNMLGSNIAISELMVGGTLI
                     LGMTLSNMIITSIIGNLILVAIIMIQGYIGYKEGLNTYVLAKGAFGEIGGKYLISLLL
                     GITSFGWFGVQAGVAGLSVQKIFPSVNLTLVTVILGLFMVVFALYGFKAMAKFNYLVI
                     PPLMILMVWGVFKAFSTYGVEAIYNYTPQTTMSMVEGLNIVVGLVIVGAIISPDQLRY
                     TRRVKDIWIISFLGLGIISLFQQVAAGVMSMGAPTWDITEVLANLGFGWVAFVILILA
                     SWSTNVSNAYSGGLALKTIFPNVKRNVLTLVAGLIGTIIAATGIIFKFQSFLSFLGIA
                     VPAIAGIMWCEYYFIQGRTYKHREGINWIAVISWLIGFAASYYSSKINFLIPPINGIV
                     VSMVIYYILMKCFGIKDK"
     gene            17472..18278
                     /locus_tag="KR257_002426"
     CDS             17472..18278
                     /locus_tag="KR257_002426"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890994.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="carbon-nitrogen hydrolase"
                     /protein_id="HBH0031109.1"
                     /translation="MGRKVKIGIIQQHSVLGDVKKNIEKAVEMIDDLGKQGADIICLP
                     ELFATGYNLESLGGVKTLELIREHNKYIEESMSEAAKRNNVYLISPYGTLEKGSTHVY
                     NSAVIFDRKGKIMGEYCKNHLWSLEAVYFKGGEKVEVYDADFGRFGVMICYDAGFPEV
                     SRELTLKGSEIIFIPSAWRIQDEDMWDLNVSQRALENTVYTVGVNLVSNDSNLILFGK
                     SKICNPRGTVITQLDTYREKYVLSEIDLDEIKKYREDIPYLKDRKSSYNI"
     gene            complement(18390..19259)
                     /locus_tag="KR257_002427"
     CDS             complement(18390..19259)
                     /locus_tag="KR257_002427"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454143.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LysR family transcriptional regulator"
                     /protein_id="HBH0031110.1"
                     /translation="MDLLHLKYFQTVARMEHITKASHKLNIAQPALSKTISSLEKELG
                     VQLFDRKGRYIVLNEYGRLFLKRVDSILDLVESSKKELQDTSLENSGEVKILSPAAAN
                     VLPSLLSNFRKLYPNITFNVSHTLPSSYKKSDFDLYISSSFTKLNSENSITLTCEEIL
                     LGVSINHPLSLKDEVYLSEVSDENFIVITKGENYREVIDILCESANFKPKIAFESDSP
                     YTIYALIKSLQGVGFICGKSWGLSQDPEIKLLHIKDIEFKRYLNLSWFSENYESKAVL
                     LFKNFLINYFKNI"
     gene            19631..21058
                     /locus_tag="KR257_002428"
     CDS             19631..21058
                     /locus_tag="KR257_002428"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903316.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell wall-binding protein Cwp14"
                     /protein_id="HBH0031111.1"
                     /translation="MKLTKSISSMLCLSLVLSLSPVAYANEISRTTVENTLVGQDRYQ
                     TAVEVSKKGWSSANEAVVVNSESIVDALAVTPFAKLKNAPILLTEKNNLNSQTEKELK
                     RLGVKKVYIIGLSSSVSNDVQKQLESNNLTTDRVGGSDRYQTALSIAKKIEGLKDISE
                     IAVVNGYTGLADAVSIGSVAATNGMVILPVSDASGISSFKDFIESKNINKSYIIGSTN
                     AVSDKIKQSLPNSERIGGADRNETNGKVIEKFYTSNKLNNVFVAKDGMKNQNQLIDAL
                     AVGVLASKENSPVLIVGEQLSATQKSVFSNKNATSITQVGSGGNENAFKELKDLQANS
                     NNKRVMYVTNTDKVNIRNDATIEASVIGYLNNGDEVEVLDVLKTGWVKIKYNEGIGYV
                     SGSYLTNNKPDNSNENIKIKYVKEKDGLNVRKGPSTEDEKIGHLSYGSKVETIEMFAT
                     GWVKIKYNGGYGYVSNDYLSDTPVI"
     gene            complement(21135..21404)
                     /locus_tag="KR257_002429"
     CDS             complement(21135..21404)
                     /locus_tag="KR257_002429"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903315.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0031112.1"
                     /translation="MKFEYYYLIQDIAGILLAFIGLRMSIIGFRILSMRGLSINTLLI
                     VIKYCLFTIAGLNLLISKFGIRHWIWSVCMLIISIIINPRIKVSK"
     gene            complement(21407..22849)
                     /gene="nhaC"
                     /locus_tag="KR257_002430"
     CDS             complement(21407..22849)
                     /gene="nhaC"
                     /locus_tag="KR257_002430"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897909.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Na+/H+ antiporter NhaC"
                     /protein_id="HBH0031113.1"
                     /translation="MKMNTERKIPSFRYSLLVMLAIIALTSVGIVVFNASITTMFLLS
                     WLIVVPAAMKLGYTNDEIEAFGFEVGKDAFQSNLIILSVGVLIAAWIAAGTIPTVVYS
                     GLTIITPKYFLLTTLIVCSLTSVATGTSWGTLGTSGIAMMSIGTSMGIPLGLTAGAVI
                     SGAFFGDKMSPLSDSTNLAAAVCKTDVITHMKHMFYTTGPAYVICIVLYTVIGFKYSN
                     NTIDYVQINQIKDVLNSNFHIGLVAMIPIIFLLLLLLLQKPPIISILSSAIMGLIIAV
                     FQEGEKIGDVLNYMLSGFTIDTGFVYADKLLNRGGIMSMAETVLLVFVVFVIAGILQK
                     TGFLEVLLQPLITKIGKSRTKLVGSTFIVSYFANAFSSSMMFTSVFVGTLMSPIYKEF
                     KLKPQNLSRIIEDTATLGGPLIPWNSNAVFCAQTLGVSPLEFIPYCFLSWITPIISFI
                     YGVTGFTMLTYTDDEIEELEIFDTAQRRVD"
     gene            complement(22874..24040)
                     /locus_tag="KR257_002431"
     CDS             complement(22874..24040)
                     /locus_tag="KR257_002431"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897908.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pyridoxal phosphate-dependent aminotransferase"
                     /protein_id="HBH0031114.1"
                     /translation="MNYNFNEIVDRSNNFSSKWSEMEKKYGTNDLLPMWVADMDFKAA
                     PCIIDSLKNRLEQEIYGYTTRPDSYNESIVNWLDRRHNWKIKSEWLIYSPGVIPAISL
                     LINELTKANDKIMIQEPVYSPFNSVVKNNNRELIISPLQKLENGNYIMDYEDIENKIK
                     DVKLFILCNPHNPVGRVWTKDELKKLGDICLKHNVKIISDEIHSDIILKKHKHIPMAS
                     ISKEFEKNTITCMAPTKTFNIAGLQSSYVILPDEKYYKLLDDAFTRIDIKRNNCFSLV
                     ATEASYNNGESWLESFLEYLESNIDFAIKYINENMPKLKVRKPEGTYLLWVDFSALGL
                     SDEELESILVQKGKVALNQGNSFGIGGSGYQRINLACPRSMLEEALIRIKNAIN"
     gene            complement(24265..>26366)
                     /locus_tag="KR257_002432"
     CDS             complement(24265..>26366)
                     /locus_tag="KR257_002432"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426412.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=3
                     /transl_table=11
                     /product="sigma 54-interacting transcriptional regulator"
                     /protein_id="HBH0031115.1"
                     /translation="IVSLKKDAGEIYENQIRQFLGDNLKINLYSFEEGNLKFFKEKLI
                     LLSAYLKYDEIVKLSHYDAQIIVPKLTFEKNSIDMISKLEKDKIIYVYNLSKDMAIET
                     ISLIHRLGIDNINILPCYPEIEFTPTDAVILTPGEKILPKFKNCEVIDLKYRIIDLSC
                     IVEIATKTKLKHLIKDDLIKKYVEKIIPTSYSTGELLLDANKFERQFDLLLSIIDDGI
                     ICTNNDGIIQFYNHMARKILSINANEMIDSFVGDCIKDINFQSILTNKTPFFEKLIKI
                     NHIDINLEIKHIQLNVFDGFILKMTKFSQLEKKQAKLRAQLVNSGNISKYTFDDILGS
                     SIQTINTKKIANKMAQSNSSILIIGESGTGKELFAQSIHSASRRKDGPFVAVNCSTFQ
                     ENLLQSELFGYDEGAFTGAKKGGKIGLFELANNGTIFLDEIGEMDLNSQSKLLRVIQE
                     KQVRRIGSNNVIDIDVRIIAATNRNLKELVSKNMFRRDLYFRLNVLPLKIHPLRERPA
                     DIFEIFGSLKYDIPCNFILSEEVKEIFKMYRWEGNVRELRNLGEYFCYLEKDIIEICD
                     LPEYILDTIDSNYSRTVCNKVSNNIKKYQFNIGKDKNIMKYDYNFKRSLDEYIFILDN
                     LKKAYDLKERIGRKSLCKIALEENRFLTEQQIRNMLLELQDFGLVDILVGRGGSIITS
                     KGVEFLKNINRSNKLNS"
BASE COUNT        10180 a         3012 c         4537 g         8637 t
ORIGIN      
        1 aaaatataaa tatagactta tttaaaaata ttattatgat tattgcaagt gttagttggg
       61 ttggaatttg tgttctgtgc ccaatagaac ataggagtaa ccctataagt gatagggaaa
      121 aattggttta taagaaaact gctatattta tatctacagt agtgttattg ataacaattt
      181 taagtctttc tttgagtata tttgtagatt atttcacata tagcgcattt gccatgtttt
      241 ggatttttgt gatgttagta ttaggtaagt taaaagctaa agtataagta aaatatgtat
      301 gagggagagt taagttatga aaaagtttat tgtaagattt atgaagtttg ctagctcatt
      361 ggcacttagc actgctattt tgtcagctaa tagtacctgt ccttggatta ttcatcagcc
      421 taaagtaccc aaagaaatca gcaatctaaa gaagacaaat taaatacaag cacttattta
      481 tacaaaatta tcaggaaaaa agaaattatt atattttaat aagattaaaa caatataaaa
      541 tcagatacaa aatttatttt atttatttta taggagccta atacctattt ggtaatatat
      601 tagtgcgcca atttaggggg atatagtgta tttaatgaaa tgacttacgg agagtaagtc
      661 atttttgtat tgtatgtatt ttatgtaaac ttatgatata atgaagggta aagtttaatt
      721 aaaataataa aaaactttag tatagatagt aatttaggag gtagggtatg agtatgatac
      781 ataaattttc tatgaatgga tataatatcg ttttagatgt gaatggtgga gctgttcatg
      841 tgttagatga tgttgcatac gatttgttag atttttataa agaaaaaagt aaagaagaaa
      901 tattagagat attaaaatca aaatatcaag aagaaaaaat aaatgaagca tatgaagaaa
      961 tattaaattt ggaaaaagag ggtcttttat atacagaaga tacatatcaa tatcatccaa
     1021 gctttgtaca tagagagcct gtagtaaaag ctttatgttt aaatgtagct catgattgta
     1081 acttaaaatg taaatactgt tttgcagctc aaggtgattt tggaggagaa aaagaactta
     1141 tgagttttga agttggtaag gcagcaattg actatttgat tgctaattca ggaagtagaa
     1201 agaacctaga gatagatttc tttggtggag agcctttgat gaactttgag gttgtaaaac
     1261 aactggttga ctatggaaga agtgtagaaa aagattataa taaaaatata agatttacaa
     1321 taactacaaa tggtgtactg ctaaatgatg agattataga ttatataaat gaaaatatgc
     1381 ataatgtagt tttaagttta gatggaagaa aagaagttaa tgataatatg agaccaactt
     1441 taaatgataa aggaagttat gatattacat taccacgatt taagaaactt gtggaaaaaa
     1501 gagcaaaaga taagtattat tatataagag gtacttttac aagagataat ttagattttt
     1561 caaaagatgt tatgcatttt gcagatttag gatttaaatt aacctctgta gagccagttg
     1621 ttggagatga gagtaatcca tatgcactta gagaagaaga tttacctaag atatttgaag
     1681 agtacgaaaa atttgctgta gagtatgcag atagacaatt acaaggagat ggatttaaat
     1741 ttttccattt tatgatagac ctaaatcaag gtccatgtgt aataaagaga ataactggat
     1801 gtggagctgg aaatgagtat ctttctgtaa ctccaaatgg agatatatat ccatgtcatc
     1861 aatttgttgg aaatgaagaa tttaaaatgg caaatatatt tgatgaagaa atagtacttc
     1921 cagaaaattt aaaaaatatg tttagagaag ctcatgtata tactaaagaa gagtgtaaac
     1981 aatgttggaa taagttttac tgttcaggtg gatgtcatgc aaatgcgata aactttaata
     2041 atgacatatc aaaaccatat gaattaggat gtgaaatgca aagaaaacgt acagagtgct
     2101 ctataatgat acaagctaag ttaatgttag aaggagcaac caactaaatt tatattttaa
     2161 aggagttgtt tatatatgat tagagattat ttagaagata aacctttaat tgacgaaagt
     2221 gtatttgtgg caaaatcagc agatgtaatt ggaaatgtta aaataggcaa agattcaagt
     2281 atatggtaca atgcagtagt taggggtgat gaaggaccaa taactattgg agaaaacact
     2341 aatatacaag attgttctat agtgcatgga gatacagaaa ctataattgg taacaatgta
     2401 acagttgggc ataggtctat agttcatggt tgtaaaatta gtgataatgt gttaattggt
     2461 atgggttcaa taatattgga taatgctgaa ataggagaat atactctgat aggagcaggt
     2521 acactaatta catctaataa gaagtttcca ccaggtgttt tgataatggg ttctcctggt
     2581 aaggttgtta gagagcttac agaagaagat aaaaaatata ttgatgaatc ttatgaatgg
     2641 tatttagagg cagcacaaaa tcaaaaatat tagtttaaag agtggttgtt tcaaaacata
     2701 tttaaatctg ttttgaggca accactaatt tattttatta gattttgttg atattttagt
     2761 tttcaaaaag tatttgatta aaccagatat aaaatgtcaa aaataaaaat taactgagtt
     2821 aaataatttt aataaaattg gtagtatatg tgataaaatt aaatattaaa gaggatatag
     2881 gatattagaa tatcaattgg tgaaataatg tcatatacga taaattaagg tgtaagtttt
     2941 tgggtatacc tatcttagga gtgaaaagat ttgagaataa gttatagaaa tttaaagcga
     3001 tatagagaaa ttggatatgt tttaataaag tatggtttta gttttattgt agaaagacta
     3061 aatatagaag gaattgccta taaaatacca ctatttgacc caccagaaga aataaaaaat
     3121 atgacaactg gtgagagaat gaaaagagtt ttagaagaac taggacctac atatataaaa
     3181 ataggacaga tattgagtac aagaaaagac ttgttagacc aggatataat tgatgaaata
     3241 tcaaaactca gagatgatgt agagaaattt gattcaaata tagctattga tatatttaaa
     3301 gaagaagtgg gtttaagtat agaagaaata ttcttagaat ttaaagaaga accaatagca
     3361 gcagcttcaa ttggtcaagt ttatgaaggt gtacttaaaa cgggagaaga agtaatcgta
     3421 aaaattcaaa gaccaaatat agagaaaata ataaaatctg atttagagat tcttagaact
     3481 attgcaaata ctttaaaaga tttaaaaaag gattttaatt tagatttagt acagatgatt
     3541 gaagaatttc aaactcaatt aatgagggaa cttgattata catttgaagc tataaatgca
     3601 actaaattct ctaggatatt taaaaatagt gatgaagtat atatacctaa agtatattca
     3661 gaatataata ctaagaaaat tttagtaatg gagaaagtta atggtacaaa gttaagtgat
     3721 gtagaaaaaa taaggagact aggttataac acaaaaacta ttgttgaaat aggagttagg
     3781 tcatttttta cacaggtatt atctcatgga ttttttcatg cagacccaca tccaggtaat
     3841 atattcgtag ttgctaaaaa taagatagca tatatagatt ttggaatgat tggaattatt
     3901 gataataaaa ctttaaacca attaaatgaa attgcattag caggtgtaga aaagaatgtt
     3961 gacaagataa tatatctatt gatagaaatg gatgcattaa atggagaggc tgatattaag
     4021 ggacttagac aggatttact ttatctaata cattattact atgatatttc tatagaaaaa
     4081 ataaatgtaa cagatatatt aaatgaacta tttaggtttt ttagacagta taaaatagtc
     4141 atgcctgcac aatttgtaac tcttgcaaag acagttataa cattagaagg aacaagtaga
     4201 actttaaaca cagatttttc ttttggttct atgggaaaag agtttatgaa acatcattat
     4261 aagagtaaat ttaaccctaa aaatgttgtt ttaagttcaa gacaaaatgt agaagaaata
     4321 ttactggaca taaaaactat tccaaagcaa ttaaaagcaa ttttaaaaaa tatagaaaga
     4381 aataatataa aaatgcaaat tgaagatgtt aaaatgacga ggttagaaaa ttgtataata
     4441 gagctaacat ctcaaatatc tttgagttta gtgttggcat ctattatagt aggttcttct
     4501 cttataattg catctccaaa tatagaaaat aatatatgga taaaatttac tgcaatagcg
     4561 ggtttcttta tatcctttat aataggcctt tgcttagtta taagaagtat taggtcaaaa
     4621 tacaaaaaag attaggggga attaaatttg aaaaaatgga tattgaagta taaaggtaag
     4681 atagaggaaa gtgaatttag caaaaaactt aatatttccc cggaaatctg ccaaatttta
     4741 aaaaatagag ggatatgtac tgaaaaagat tcagaaatat ttatgaatcc atctttagat
     4801 tatttaagag accctttttt aatgaaagat atgcaaaaag ctgttgatag aataaagtta
     4861 gcagttgaga agaacgaaaa aatttggatt tacggagatt atgatgttga tggtgtatca
     4921 tctacatcta tcttgtgctt atattttaag agtataggtt acaatgttga ttactatatt
     4981 cctaatagat tagaagaagg gtatggtata aatgaagatg ctattaagct tataagctct
     5041 aggggatgtg acttgattat aagtgttgac tgtggaatta catcagtgtc tgaggtcaat
     5101 acagcgaatg atttgggcat agatgttata attacagacc atcatgaatg tcaaagtgaa
     5161 attccatcag cctttgcagt aataaatcca aaacaagaag attgtaatta tccatttgat
     5221 tcactatgtg gatgtggtgt agcatttaaa atgattcaag ccttgactcc aaaagaagaa
     5281 tttaaaacta gtatgtataa ttatttggaa atagtaacac tagcaactat ttgtgatatt
     5341 gttccactta tagatgaaaa tagaataatt gtaaaaaatg gtttaaaatc aatgaaagaa
     5401 ggcaaaaata ttggattaag ggagcttata aaagtttgtg gtgtagaaag tgataagata
     5461 ggttcttctc atataggttt tgcaataggt cctaggataa atgcttcagg tcgattggga
     5521 tattcttact taggagtaga gctatttact actcaatcac aagaagaggc agtagaaata
     5581 gctagtatat tggaagaaaa aaataatgaa agacagatga tagaagctaa gatgtatcat
     5641 gaagctgaag aaatgctaaa gtctaatagc agatacaatg atgacaaggt gttggtttta
     5701 gctaaagagg gttggcaaca tggaataata ggaattgtag catcaaagtt aactgaaaaa
     5761 tactacaaac caacaattct tctaggtata gaaaatgggg aggctactgg ttcagcgagg
     5821 tcaataaaag gatttaatat atttgaagct ctcataaagt gcaaagactt gatgactaag
     5881 tttggtggtc atgaacaagt agcagggtta tccttggatt cagacaatgt agaaatttta
     5941 gcaaatgaaa taaataaatt tgcagattat aatttaactg aagatgatat gatagagaat
     6001 gtaaatgttg agtttgaatt acaagaaaat gtaataaatt taaatcttgt agaagaatta
     6061 cataagttag aaccctttgg attaaataat cctaatccta gatttatagt tagaaattat
     6121 attttaaaag atttgaaagt tataggtaag aatcaacaac atctgaaatt aagcatagaa
     6181 aaagagaaaa gctatgaatg tataggattt aatatgagtc atttaaaatc aatgtataaa
     6241 gtaggagaca aggtagatgt actattccaa ttagatgaaa ataactatat gggaaatagg
     6301 aaagtacaat ttttacttaa agatatacga ttggctcgac ctaaaagtgc aagtaatgac
     6361 aaactttcat tgaaattaat gtcaaaaata ataccaaaag atactcaaag cctgtataat
     6421 atatctgtgt ctgattttga attatttgat ggaaatacag atataaatat atttgattat
     6481 tttgaaaaag atacactaat aatatctaat tctataaatg gattttatag agcaatgtca
     6541 gatatatcac ttatagattt ggattttaac ataaattaca atattattga agatgatagc
     6601 aaaaatactg ataaattaga gcttatattt tctcctaata ttgataaaat agacttaaaa
     6661 agatataata atattattct ttatgattat ttatacaata aaggcgaata ttcgtatata
     6721 tatgagaata aaagagaaga aagtgaaatt ataaaatatt ataataaaac agacctatta
     6781 tatttaaaga atgtagttag taatatagtt ccatcaagag atgaatttat aacaatttat
     6841 aaacaagcac tcataaaaaa agaaattgat ttggatatgg taaatataag ggaaactttt
     6901 aatgtaattc cattaaagtt ttttacgata ttaaatgtat ttagagaatt aaatttactt
     6961 gactttaatt taaattatga aaaaaattct gtactcataa gaatattgcc aaaaccacag
     7021 aaaaaattag acttaaatga gagtttaata ctcaataatc taaaaaattt agaaaaacaa
     7081 tacaatagca gttattagga ggcgtttccc atggatttaa aaaactttat aaggaatatt
     7141 gatgatttcc caaagccagg catagatttt aaagatgtga caactctatt taaagatgga
     7201 gatgcattta aatatgcagt ggattctata gttgaagaat tgaaagataa agatgtagat
     7261 ttagtaatag gaccagaagc aagaggattt ttgatgggta cacctgtagc atatgcttta
     7321 ggagtaggat ttgttccaat tagaaaacct ggaaagttac caggtgaagt tgagagttat
     7381 gagtatggat tagagtatgg tacagatact ttagagatac ataaggatgc aattaaaaag
     7441 ggtcaaaaag tagcaatagt agatgattta ttggctactg gtggaactat ggaagccgct
     7501 gccaagcttg tagaaaaatt aggtggagaa gtagtttcta tgcaattttt gattgagcta
     7561 aaattcttaa atgggagaga aaagttgtct aactatgatg ttaattctct tataaaatac
     7621 tagtactttt ataatagttg gtataacacc aactattttc atatatatta aaattttata
     7681 caaaataggt ggttatatgc atgataaaga attacaagaa ataattgaaa aaataaaagt
     7741 ttatgcacct aatgcaaatt ttgaaatggt tgaaaaagcc tataatcttg caaaaaaagc
     7801 gcatgaagga caatatagaa aatctgggga accatacttt attcatccat tagcagttgc
     7861 aaatatttta atagagatgg aattagatat tgaaactata acagcaggtt tacttcatga
     7921 tgttgtagaa gatacagaat atacctatga agacataaaa aaagaatttg gcaaagaagt
     7981 agcggatttg gttgatggag taactaaact tggtcaaata aaatatcgtt cgaaagaaga
     8041 aactcaatct gaaaatttaa gaaaaatgtt tttggcaatg gcgaaggata taagggttat
     8101 acttataaaa cttgctgata gattgcacaa catgagaaca ttaaaataca tgcctccaga
     8161 aaaagcaaag tataaagcaa aagagacact tgaaatttat ggtggtatag ctcatagatt
     8221 aggaatttcc aagataaagt gggaactaga agacagagca ttaagattta tggacccaga
     8281 agggtattat gatttagtta gtagagtatc aatgaagaga agtcaaagag aggattatat
     8341 tcaaggaatt gttgaacttc ttaaagataa gtttaaagat ttaagtatac catgtgatgt
     8401 atatggtaga ccaaagcatt tttacagtat atatagaaag atgcaaaaaa aacataagac
     8461 ttttgaagag atttttgatt taacagcagt aaggatattg gttgataatg taaaggattg
     8521 ctatgcagta cttggtatag ttcatacatt atggagacct attccaggaa gatttaaaga
     8581 ttatatagca atgccaaaac ccaatatgta tcaatcatta cacaccactg ttgtaggtcc
     8641 tgatggagaa cctttagaga tacaaataag aactcatgag atgcataata tagctgaaaa
     8701 tggtatagca gcccattgga aatataaaga aggtatctct agcaaagagt caaaggttga
     8761 agaaaaactt caatggttga gacagatgat ggagtgggaa aaagatttaa aagacccaca
     8821 agagtttatg gatgcactta aagaagatgt atttaatagt caagtttatg tatttacgcc
     8881 aaaaggagac gtaattgaat taccagcaga atcaacacct atagattttg cctatagagt
     8941 tcatacaaat gtaggtaata aatgtgtagg agctaaaatt gatggaagaa tagttcctat
     9001 tgattataag cttcaaaatg gtaatattgt cgaggtactt acatcatcta attctaatgg
     9061 accaagtagg gattggctta atatagtgaa gaccccaaat gcaaaaagta gaattagaca
     9121 atttttcaag aaggaaagaa gagaagaaaa tgttgaccgt ggaaatacaa tattagaaag
     9181 agaatttaag aagcatgata taccacaaaa agaccctctt gttgaaaaat atatggcatt
     9241 agttgctaag aaatttaatc agccaagtgt tgaggactta attgccactg taggttatgg
     9301 tggtataatg tcatctcaag tggtatctaa ggtaaaagac ctatatttaa aagaggttaa
     9361 aaaagctaaa aaggaacaac agatacaaga agaagattta aataaacaca atataagtga
     9421 aacagaatac agtaaaaaga gaaagaaaaa cgcatcacaa ggaattatag taaaagggct
     9481 tgacaatatc ttagtaagat ttgctaagtg ttgtaatcct cttccaggag atgaaattgt
     9541 aggatatatt actaagggta ggggagtagc catacacaga gctgattgcc caaatgcaaa
     9601 caataatggt gatttcttcc aaaatagatt ggtggaggtt tcatggagtt cagcaggaaa
     9661 aggtaagttt gaagcggaaa ttcaaataaa agctattgac agaagaggaa ttgttaatga
     9721 aataactcat attgttgcaa tggataaact tagtttaaac ggaataaatg caagaaaagg
     9781 taaggatagt attgtaagta taaacttact tgtagaggtt aatgacacag aggaattaaa
     9841 aattctaatg aaaaaattaa aagcaattcc tggtgtagaa agtatttata gaatgacaaa
     9901 ttagagttaa aataataggg aggaaactat gagagcagta gtgcaaagag tatcttcatc
     9961 taaagttaca gtagatgaaa acactatagg tcaaataaat aaggggttac tagtattgtt
    10021 aggagtgact catgatgata aatcaagtga tgtagattat atgattgata aaatattgaa
    10081 tctgagaatt tttgaagatg aaaatgacaa gatgaattta tctctaatgg atataggtgg
    10141 agagctttta gtagtatctc aatttacttt atatggagat tgcagaaaag gaagaagacc
    10201 tggatttagt aatgcagcta gaccagaact tgcaaataac ctttatgaag aatttgtaaa
    10261 aaaagcaaaa gataaaggtg tgacagttgg tacaggtcaa tttgcagctc atatgatggt
    10321 agagttaact aatgatggtc cagtaacaat actattagac tcaagtaaat ctttttaagg
    10381 gggaaaactt taatgattat aaaaaaattt gtagatagtt attttggagt aaatacttat
    10441 gtattaggtg atgaaaagac taaaaaatgt gcagttatag acccaggtgg aagtttagta
    10501 gagacattaa gttttgtaaa agaaaatgaa ttaaatattg aatatattat ccttactcat
    10561 gggcatggag accatatagg atatgttaag gatattaaag aaaaaactgg tgctaaagta
    10621 gttgcacatg ttgatgaaaa agaattatta aatgacaaaa ataaaaatct aagttataca
    10681 atgagatgtg gagcgcaaga gtttgatgca gatatctatg taaatgataa agacaagctt
    10741 gaacttggtg aattaaaaat gactttcttg catactccag gacatactca aggatgtatg
    10801 tgtataagag ttgaagatga aatgttcaca ggagatactt tgtttgctgg aagtattggt
    10861 agaactgatt tatatagtgg agactttaac caaatggaaa aatcacttaa gaaattatgt
    10921 aaatatgaag atgctgttag agtatatcct ggacatggac caaccagtac tctaggggtt
    10981 gaaaagaaga caaatcctta catgtaattt tatattagta tttaaaaaag tataaaatat
    11041 ttaataacta tattagtgag ggggttcttc tactgttaaa tagaaggagt taagttgatg
    11101 ttgtatgttt ttttaaaagg acatgattat aagtatgaag tagcagaact tataaaattg
    11161 tttactagtg aatttaagtt taaagactct aatgctaaca ataatataga gtcaaagcat
    11221 ttaataaata gattgattta tgagaatggt gtattattct caagtactga atactatgaa
    11281 aatggaaact taaagtacga gtcaatacag aatatagaaa atatgaatct tgaattttta
    11341 gatggatttg atagcagcaa aacgattgaa gaatttctta atagcctaga tagtgaaagt
    11401 aagaggaact ttaaaaagct gtgtaaagaa aatatcaaaa aaagcatgtt tttagtgctt
    11461 aaacaagtat ttaattctta tgtaccatgg ggaattttga ctggtattag accagtcaaa
    11521 attgtccaca atttaatgga taaaaagcta gatgataata gcataagaac cattctaaaa
    11581 gataattatt ttataataga tgagaaaata gatttagctc ttgaaatagc taaaagagag
    11641 cgattattta tgtatcctat agataaaaat aaaatttctc tttatgtaag tattccattt
    11701 tgtccaacta gatgtgtata ttgttcattt ccttcaaatt cattaaaaca atttggacat
    11761 ttaaaaagag aatatgttta taaattgatt gaagaaatta aggggtttgc caaagttatt
    11821 aaggatacta agaaagaagt tgaaactcta tatattggtg gtggaactcc aactacactt
    11881 gatgaggaag aattggattt gcttataaat tcattgttca atgaattaga tttaagtaaa
    11941 attaaagaat ttactgtaga agcaggtaga cctgacacta ttacagaaca aaaactaaga
    12001 gtgttaaaaa aacacaatgt tagtagaatt agtataaatc ctcaaactat gaatgatgat
    12061 accttggtaa agattggaag agagcataga gtatctgatt tagtagattg ctttaatatg
    12121 gctcgtagaa tgggatttga taatataaat atggatataa ttttaggtct tatagatgaa
    12181 gacttaaata tggtaaagaa cacattggag gagataaaaa aactttctcc tgaaagcctt
    12241 acagttcata cattagccat aaagagagca tctaacttaa atataaatat ggataggtat
    12301 aaagaacatc taacacaata tgaagaaatg gtaaaaatga tagatttatc aatgaaatat
    12361 gcaaaagata tgggattaaa tccatattat atgtacagac aaaaacatat gttgggaaat
    12421 ttagaaaata taggttatgc taaagaagga tatgagtgca tttataatat acagattatg
    12481 gaagaaaaac aaagtaacta tgcattaggt gcaggtgcta tatcgaaatt tgtctatgta
    12541 gatgaagata gaattgaaag agtagaaaat gtaaaaaatg ttgaacaata cattgaaaga
    12601 gtagatgaaa tgataaaaag gaagaaagaa gaggtatata aaaatgttga ctaaagctcc
    12661 tagaggaact aaagacataa ctccaaaaga ggcttacaaa tggcgttatg tagaaaataa
    12721 atttagagaa atatgtgctt tatatggata tgaagaaatg gtaacaccta tatttgaaca
    12781 tacagaactt ttcaagagaa gtgttggaga tactacagat atagttcaaa aagaaatgta
    12841 ttcttttaaa gataaaggtg atagagaaat taccctaaag ccagaaggta cagcaggtgt
    12901 agtaagagca tttatagaaa ataaattata tgcagatact caaccaacaa aattatttta
    12961 tgtgacacct tgttttagat atgaaagacc acaagctggt agacaaagac aatttcacca
    13021 atttggaata gaagcacttg gaagtgatac tccttcaatg gatgctgaaa taatcgcact
    13081 agctgttcaa ttttttaatg aagttggatt aaatgatttg gtagtgagta taaattcagt
    13141 tggctgtcca gtttgtagaa aagagtacaa tgctttatta aaagagtatc ttgactcaaa
    13201 agctgatata ttgtgtgata cttgcaatga gagaagagaa aaaaatccaa tgagggttat
    13261 agactgtaaa aatcctacat gtaaagaaaa tatcaaagat ataccattta ttgcagacca
    13321 tttgtgtgat gattgtaaat ctcactttga taaacttcaa gaatacttaa aggaaatgaa
    13381 tataaacttt gtaattgata aaacaatagt tagaggctta gattactata gaaaaactgc
    13441 ttttgaaatt atatctaatg atataggagc tcaaagtact gtatgtggtg gaggaagata
    13501 tgatggtctt gttgaacaat taggaggacc aaaaggtata agtggaattg ggtttggact
    13561 aggaattgaa agacttttac ttacacttga aggtaatgga attgaaatag aaaaccctca
    13621 atctacggat atatttatag taactatagg tgaagaagca aatacaagaa gctttaaatt
    13681 gttaaaagac ttgagacaaa atcatataag tgcagataaa gaccatatag agagaagtgt
    13741 taaagcacaa tttaaatatt cagataaaat aaattcaaaa tttacaatag taattggaga
    13801 tgatgagctt aaaaatgaca ctgcgacatt aaaaaatatg aaaacatcag agcaaactac
    13861 tgtaaaatta agtacattag ttgaagaatt aaagcaaaag ctgtaaaata agaaagtatg
    13921 atgttttgtg tattagataa atatatagca ttaaaattaa ataaaatgga ggtagtatct
    13981 tggaaacttt aaagggttta aagagaactc actactgtgg agagttgaga gaaaaaaaca
    14041 taaatgaaga agtcgtactt atgggatggg tacagaaaaa aagaaattta ggtggtcttg
    14101 tatttgttga tttaagagat acaagtggat tatgtcaaat agtttttgat acagatgtag
    14161 ataaagaagc ttttgaaaaa gctgaaaaat taggggctga atttgtaata gctgtaaaag
    14221 gaaaagtatg cgaaagacaa tctaaaaacc ctaatatgct aactggtgat atagaaatat
    14281 ttgcaactga acttagactt ttaaacaagt cagaaactcc gcctatttat ataaaagatg
    14341 atgatgatgt ttctgaagca ctaagattaa aatatagata cttagattta agaaaaccat
    14401 ctatgcaaag aaatttaaaa ttaagacata aagtaatgaa tattacaaga aattacttat
    14461 caaacaatag attttgcgaa atagaaacac catttttaat agctccaaca ccagaaggag
    14521 caagagatta tctagtacca agtagagtta atccaggaaa attttacgca ttaccacaat
    14581 caccacaatt atataaacaa ttattgatgg taagtggtat ggatagatat ttccaaatag
    14641 ttaaatgctt tagagatgaa gacttaagag cagatagaca accagagttt acacaaatag
    14701 actgcgaaat gtcttttgtt gagcaagaag atgttatgag tatgattgaa ggtttgcttg
    14761 aagcgatatt taaagaagtt ttagatgtag aattggcact tccacttcct aagatgactt
    14821 atgcagaagc tatgtctaaa tatggttcag ataaaccaga tactagattt ggatatgagt
    14881 taacagatat atctgatgtt gtttgtaact gtggatttaa agtgtttgct gatgctacac
    14941 aaccaggaaa aagtgttaga ggtataaacg taaaaggcaa agctgacgac tttactagaa
    15001 aacaaatatc atcactagaa gaacatgcta agacatatag agcaaaaggt cttgcttgga
    15061 tgaaagtagg acaagaagga gtaacttctc caatagcaaa attctttaat gaagaagaaa
    15121 tgaacgctat acttacaaga atgaatgctg aagtaggaga tttactttta tttgtagctg
    15181 ataaaaactc aatagtattt gatgctttag gacaagttag acttgaagta gcaaataggc
    15241 ttaatctatt ggataaaaat gtatataact tactatgggt aactgagttc ccagtttttg
    15301 aagaagatga agaaacaggc acattctcag caatgcatca cccatttaca tcacctatgg
    15361 atgaagattt agacaagtta gaagaaggtg ataagtcatc tttaagagcg aaagcttatg
    15421 atattgtatt gaatggttat gaaataggtg gaggaagtgt tagaatatca aattctgatg
    15481 ttcaatcaag aatgtttaaa gcacttggtt ttacagagga aagagctaat gaaaagtttg
    15541 gttatttatt agaagcattt aaatatggta ctcctcctca tgctggtcta gcttttggtc
    15601 ttgatagact tgttatgtta cttgcaggaa ctgataatat aagagaagtt attgcattcc
    15661 ctaaaaatca aaatgctgtt tgccctatga caaatgctcc tacattggcg gaagatgagc
    15721 aattagaaga attaagtata aaagttgata taaaagataa tgaataatat gtagttgcaa
    15781 gaaactaaaa tgtaaaaagt ctggatataa aatatattta tattcagact ttttttatta
    15841 gaattatttt atattttttc tctatatatt ttcataaatt atacttatat tcttaaccaa
    15901 tataattaaa atactatgtt taaaaatttt acataaactt gattatttta gaaactactt
    15961 ctgtaatgag tacacgattt taattaaaga atatataaca aatttgaaat aagtctaata
    16021 tatgacttaa tagattaaat taaaataata aatttggact atttatctat ttataactta
    16081 aattatatca aattgataac aaactagata ttatactttt ttgtagaata gaattacaat
    16141 tatataaaga aaaattctat taatagtgaa aaaaaagtag aaaaaagtag aaattattct
    16201 tttataaaga aagggaggga taatattgca agagagagaa gaattagttt taaatccagt
    16261 tccaaaagag gaaagagttg gatggttagc tccattgttt aatatgcttg gttctaacat
    16321 agctatatct gaactaatgg ttggaggaac tttaatttta ggaatgactc tttctaatat
    16381 gattattaca tcaattatag ggaacttaat attagttgca attattatga tacaaggtta
    16441 tataggttac aaagaagggt taaatacgta tgtattagct aagggggcat ttggagagat
    16501 aggaggaaag tatcttatat ctctattact tggtataact agttttggat ggtttggtgt
    16561 acaagcaggg gttgcaggac tatcagtaca aaagatattt ccaagtgtaa atctaacatt
    16621 agttacagtt atacttggat tatttatggt tgtttttgca ctgtatggct ttaaagctat
    16681 ggctaaattt aattacttag ttataccacc acttatgata ttaatggtgt ggggagtttt
    16741 taaagctttt tctacttatg gagttgaagc tatttataat tatactcctc aaacaactat
    16801 gagtatggtt gaaggtctta atattgtagt aggtcttgtt atagttggtg caattatatc
    16861 acctgaccag ttaagatata cgagacgagt aaaagatatt tggattatca gttttttagg
    16921 tctagggatt atttcattat tccaacaagt tgcagctggt gtaatgtcta tgggagcacc
    16981 tacttgggat ataacagaag tattggctaa tttaggtttt ggatgggtag cgtttgttat
    17041 tttaatactt gcatcttggt ctacaaacgt atcaaatgct tattctggtg gattagcatt
    17101 aaaaactatt tttccaaatg taaaaagaaa tgttttgact ttagttgcag gtctaatagg
    17161 tacaataata gcagctactg gtataatatt taaatttcag tcatttttat ctttcttggg
    17221 aatcgcagtt cctgcaatag ctggaattat gtggtgtgag tattatttta tacaaggaag
    17281 aacttataag catagagaag gaataaattg gattgcagta ataagctggt taataggttt
    17341 tgcagcgtcg tattatagtt caaaaataaa tttcttaata cctccgataa atggaattgt
    17401 agtgagtatg gttatttatt atatattaat gaaatgtttt ggaatcaaag ataaataaag
    17461 ggggcaatta catgggtcgt aaggtgaaaa taggtataat tcaacaacac agtgtacttg
    17521 gagatgttaa aaaaaatata gaaaaggcag tagagatgat agatgactta ggaaaacaag
    17581 gggcagatat aatttgttta ccagaactat ttgctacagg atataattta gagtctttag
    17641 gtggagttaa aacattagaa ttaataagag aacataataa gtacatagag gaatcaatgt
    17701 cagaagctgc taaaagaaat aatgtatacc tgatatctcc atatggaacc ttagaaaaag
    17761 ggtctacaca tgtttataat tcagcagtta tatttgatag aaaaggtaag attatgggag
    17821 aatactgtaa aaatcatctg tggtcattag aagcagtata ctttaaagga ggggaaaaag
    17881 tagaggtata tgatgctgat tttggtagat ttggtgtaat gatatgttat gatgcaggtt
    17941 ttccagaagt atccagagaa ttgacattaa aaggttctga aataatattt ataccatctg
    18001 catggagaat acaagatgaa gatatgtggg atttaaatgt atctcaaaga gctttagaga
    18061 acactgtata tacagtaggt gtaaatttag taagtaatga ctctaattta atactatttg
    18121 gaaagagtaa aatatgcaat cctagaggta ctgtaataac tcaattagat acatacaggg
    18181 aaaaatatgt attatcagag attgatttag atgaaataaa aaagtatagg gaagatatcc
    18241 cctatttgaa agacagaaaa agtagctata acatataatt ctatactata atacaagttc
    18301 aatataaaat gataaaaaga ggatgtatca atattaagat taaatttatt atactttgat
    18361 atatcctctt taatattatc aactttgatt taaatatttt taaaatagtt gataagaaag
    18421 tttttgaaca acaacacagc tttagattca tagttttcgc taaaccatga aagatttaaa
    18481 tatcttttaa attcaatatc tttgatatgt aacaacttaa tctcagggtc ttgagataat
    18541 ccccatgatt ttccacatat aaatccaact ccttgaagtg attttataag agcataaatt
    18601 gtatatggtg aatcagactc aaatgctatt ttgggtttga aattagctga ttcgcacagg
    18661 atatcaatta cctctctata attctcaccc ttcgttataa ctataaagtt ttcatctgaa
    18721 acttcgctta gatatacttc atcctttaat gataaaggat ggtttattga aactcctaat
    18781 agtatttctt cgcatgttaa agttatgcta ttttctgagt ttagctttgt aaatgaagaa
    18841 gatatgtaca aatcaaaatc acttttttta taagatgatg gcaaagtatg tgacacatta
    18901 aaagtaatat tgggatatag ttttctgaaa ttactcaaaa gtgatggtaa cacattagcc
    18961 gctgcaggag ataatatctt tacttctcct gaattttcta aagaagtgtc ttgtaactcc
    19021 ttttttgaac tttctactaa atctaaaatg ctatctactc tttttagaaa caatcttcca
    19081 tactcattta aaacaatata tcttcctttt ctgtcaaata actgaactcc aagttctttt
    19141 tctaaggaag atatagtttt gcttaaagct ggctgtgcta tatttaactt gtgtgatgct
    19201 tttgttatgt gctccattct agcaacagtt tgaaaatact taagatgcaa taaatccata
    19261 gtataaaata cacctctttt aatatgactt gagttatatc aattttataa tcaactccac
    19321 attatacatt ataatataaa gtttatataa taaactacaa tatattaaaa agttatttaa
    19381 attgttattt atattttgta cataatctaa ttaaaaaaag taactttaaa tgattaacta
    19441 aggaaatgtt gttacaaact ttagttatat aaaaaattca tttgatgagc aaagtactaa
    19501 tatcaagtaa gaataaaagc ttattagata agaaaaataa tattttataa taatgatgtt
    19561 acttaaatta ttatgttata ctattttaaa taggaaaaat ttagatacta taattttagg
    19621 gggagtcaag atgaaattaa ctaaatcaat atcatcaatg ctgtgcttat ctctagtttt
    19681 aagcttatca ccagtagcat atgcaaatga aataagtaga acaacagttg agaatacttt
    19741 agtaggtcag gatagatatc aaactgctgt tgaagtaagt aaaaaaggat ggagtagtgc
    19801 aaatgaggct gtagttgtaa atagtgaatc tattgtagat gcattagctg taacaccatt
    19861 tgctaaatta aaaaatgctc ctatattatt gacagaaaaa aataatctaa attcacaaac
    19921 tgagaaagaa ttaaaaagat taggagttaa aaaagtttat ataattggtc tatctagttc
    19981 tgtatcaaat gatgtgcaaa aacagttaga atctaataat ttaactactg atagagttgg
    20041 tggtagtgat agataccaaa cagctttgag tatagctaaa aaaatagaag gattaaaaga
    20101 tatatcagaa atagctgtag taaatgggta cacaggtctt gcagatgcag ttagtatagg
    20161 ttctgtagct gctactaatg gaatggttat acttccagta tctgatgcat ctggtatatc
    20221 tagctttaaa gattttatag aatctaagaa tataaataaa tcatacataa taggctctac
    20281 taatgctgta tcagataaaa taaaacaaag tttacctaat tcagaaagaa taggtggagc
    20341 agatagaaat gaaactaatg gtaaagtaat agaaaagttt tatacatcta ataaattaaa
    20401 caatgtattt gtggctaagg atggaatgaa aaatcaaaat caacttatag acgctctagc
    20461 agtaggagta ctagcatcaa aagaaaattc tcctgtacta atcgtaggag aacaattaag
    20521 tgcaacacaa aagagtgtat tttcgaataa aaatgctacc tctataactc aagttggtag
    20581 tggaggaaat gaaaatgcat ttaaagaatt aaaagattta caggcaaata gtaacaataa
    20641 gagagtaatg tatgtaacta atacagataa ggtaaatata agaaatgatg ctacaataga
    20701 agcttctgtt ataggatatc taaataatgg tgatgaagta gaagttttag atgtgttaaa
    20761 aactggatgg gtaaaaataa aatacaatga aggtattgga tatgttagtg ggtcttattt
    20821 gacaaataat aagcctgata atagtaatga aaatataaaa ataaagtatg taaaagaaaa
    20881 agatggtcta aatgttagga aaggaccaag tacagaagat gaaaaaatag gtcacctttc
    20941 atatggaagc aaagtagaaa caatagaaat gtttgctact ggatgggtaa aaataaagta
    21001 caatggtgga tatggttatg taagtaatga ttacttatct gatacaccag ttatttaatt
    21061 ataagtaaca ataaaaaaac tgctttaatt tgtaaagcag tttttttata aaaatttaag
    21121 tctaataact atttctattt tgatacctta atcctgggat ttattattat ggatattatc
    21181 aacatacaaa cactccaaat ccagtgtcta attccaaact tagatattaa taaattcagt
    21241 cctgctatgg taaataagca gtatttaatt acaattaaaa gtgtatttat agaaagcccc
    21301 ctcatagaaa gtatcctaaa tccaataata gacattctaa gtcctataaa tgccaataat
    21361 atacctgcaa tatcctgaat taagtaatag tattcaaatt tcatattcaa tcaactcttc
    21421 tctgagcagt atcaaatatt tctaactctt caatttcatc atctgtgtat gtaagcatag
    21481 taaaaccagt tacaccataa ataaatgaaa ttataggtgt aatccaactt aagaaacaat
    21541 atggaataaa ttctagtgga cttacaccaa gagtctgagc acagaaaaca gcatttgaat
    21601 tccatggtat taatggacca ccaagtgtag ctgtatcttc tataattcta gatagatttt
    21661 gtggttttaa tttaaattct ttgtatattg gagacattag agttccgaca aatacagaag
    21721 tgaacatcat tgatgaacta aatgcatttg caaagtagct tactataaaa gtagacccaa
    21781 ccaatttagt tcttgatttt cctattttag ttataagagg ttgaagcagt acttctaaga
    21841 atccagtttt ttggagaata ccagcaataa cgaaaactac aaatactagt aaaacggttt
    21901 cagccatact cattattcca ccacgattta atagtttgtc ggcatagaca aatccagtat
    21961 ctatagtaaa tcctgatagc atgtaattta aaacatcacc tattttttct ccttcttgaa
    22021 atactgctat aataagtccc atgatagctg aacttagtat agatataatg ggtggctttt
    22081 gtagcaataa aagtaataat aaaaatatta ttggaatcat tgctactaaa ccaatatgaa
    22141 agtttgaatt taatacatcc ttgatttgat ttatttgaac atagtctata gtattatttg
    22201 aatacttaaa tccaattact gtatacagaa ctatacatat tacgtatgca ggtcctgtgg
    22261 tataaaacat atgcttcata tgtgtaatta catctgtctt acaaactgct gcagctaagt
    22321 ttgtagaatc tgatagaggt gacatcttat ctccaaagaa agcaccagaa atgactgcac
    22381 cagctgttaa accaagagga atacccatac tagtaccaat actcatcatt gctataccag
    22441 aagttccaag agtcccccaa gatgtaccag tagcaacaga agttaatgaa catacgatta
    22501 atgttgtaag cagaaaatat ttaggggtta ttattgttag tccactatat actactgttg
    22561 gtattgtacc agcagctatc caagctgcta ttagtacacc aacagaaagt ataattaagt
    22621 ttgattgaaa ggcatctttg ccaacttcaa atccaaaagc ttctatttca tcattagtat
    22681 aaccaagttt catggctgca ggaactacta taagccatga aagtaaaaac attgtagtta
    22741 tagaagcatt aaatacaact ataccaactg atgttagagc tattattgca agcattacta
    22801 acaaggaata tctaaatgaa ggtatttttc tttctgtatt cattttcata gtgcaaattc
    22861 tccttaaata tttttagtta attgcatttt ttattcttat aagagcttct tcaagcatac
    22921 ttcttggaca agctaagttt attctttgat acccacttcc tccaatgcca aagctgtttc
    22981 cttgatttag agcaacttta cctttttgta caagtatact ttctagttcc tcatcactta
    23041 atccaagtgc actaaagtct acccataata aataagtacc ttctggtttt ctaactttaa
    23101 gttttggcat attttcattt atatatttta tagcaaaatc tatattagat tctaaatatt
    23161 ctaaaaatga ttctagccaa gattcaccat tattatatga agcttcagtt gcaactaagc
    23221 taaagcaatt atttctcttt atatcaattc tggtaaaggc atcatctaac aatttatagt
    23281 atttttcatc aggtagtatt acatatgatg attgaagacc agctatatta aaagttttag
    23341 ttggagccat acaagtaatt gtattttttt caaattcttt agaaatagat gccataggaa
    23401 tatgcttatg tttttttaat ataatgtcac tatgtatttc atcagatatg atttttacat
    23461 tatgcttaag acaaatatct cctagttttt ttaattcatc ttttgtccat actctaccaa
    23521 ctggattatg aggattacaa agtatgaata attttacatc tttaatcttg ttttcaatgt
    23581 cttcataatc cattatgtag tttccatttt ctaatttttg taatgggctt ataattagtt
    23641 ctctattgtt attttttaca acactattaa aagggctgta aactggttct tgtatcatta
    23701 ttttatcatt tgcttttgtg agttcattta ttaaaagact tatagctggg ataacacctg
    23761 gactataaat taaccactca ctttttattt tccagttatg tctcctatct agccagttta
    23821 ctatagattc attgtaagaa tctggtcttg ttgtgtagcc ataaatctct tgttctagtc
    23881 tattttttaa agaatcaatt atacaaggtg cagccttaaa atccatgtca gccacccaca
    23941 taggaagtaa atcattagtt ccatactttt tttccatttc tgaccattta gatgaaaaat
    24001 tattgcttct atcaacaatc tcattaaaat tataattcat tgtaaatacc tccagtaatt
    24061 ttaattttat gttaataata ttaagcaaac aacgtgccaa tattgataat aaaaaatatt
    24121 tattcacaag ttaatattta atattaagta atttcagagc atagataaga taaaaatatt
    24181 aattatactt aaaactttgt ggaaaaggtt atttctaata aatttttaaa tatatgaaaa
    24241 tgtaattaaa taggttaaat aggtttaact gtttaacttg ttagacctat ttatattttt
    24301 tagaaactct actccctttg atgttataat tgaacctcca cgaccaacaa gtatgtctac
    24361 aagcccaaag tcttgtagtt ctaaaagcat atttctaatc tgttgttctg tcaaaaatct
    24421 attttcctct aaagctattt tacataagct ttttctacct attctttctt ttaaatcata
    24481 agcctttttt aaattatcca atataaatat gtattcatct agtgaccttt taaaattata
    24541 gtcgtatttc atgatgtttt tgtctttgcc aatgttgaat tgatactttt ttatattatt
    24601 acttacttta ttacaaacgg ttctactata atttgaatct atagtatcta atatatattc
    24661 aggtaaatca catatttcta taatatcttt ttccaagtaa cagaaatatt ctcctaagtt
    24721 tcttaattct cttacatttc cttcccatct atacatttta aagatttctt ttacttcctc
    24781 acttagaata aaattacatg gaatatcata ttttaatgaa ccaaaaattt caaatatatc
    24841 agcaggtctt tccctaagtg gatgtatttt aaggggaaga acattcaacc taaaatataa
    24901 atctcttcta aacatatttt tagatacaag ttcttttaaa tttctattag tagctgcaat
    24961 tattcttaca tcaatgtcaa tgacattatt agaaccaata cgtcgtactt gtttttcttg
    25021 tatgactcta agtaatttag attgagaatt taaatccatt tctccaattt cgtctaaaaa
    25081 tatagttcca ttgttggcta attcaaataa accaattttc ccaccttttt tagcaccagt
    25141 aaaagcccct tcatcatagc caaataattc actttgcagt agattttctt gaaaagtact
    25201 acaatttact gcgacaaaag gaccatcttt tctcctagaa gcactatgaa tggattgagc
    25261 aaataattct ttaccagtac cactttcacc aattataagg atagatgaat ttgattgagc
    25321 cattttatta gcaatttttt ttgtattaat agtttgtata ctagaaccta atatatcatc
    25381 aaatgtgtat ttactgatat taccagagtt tactagttgt gctcttaatt tagcttgctt
    25441 tttttctaat tgagaaaact ttgtcatctt tagtataaat ccatcaaata catttaattg
    25501 tatatgttta atctctaaat ttatatcaat atgatttatt ttaatcaatt tctcaaaaaa
    25561 tggagtttta ttggtcaata tgctttgaaa attgatgtct tttatgcaat caccaacaaa
    25621 tgagtcaatc atttcatttg catttataga caaaattttt ctagccatat gattatagaa
    25681 ttgaattatt ccatcgttat ttgtgcatat aattccatca tcaattatag atagtaacaa
    25741 atcaaattgt ctttcaaact tatttgcatc taacaataac tcacctgtac tataacttgt
    25801 aggaattatt ttttctacgt atttttttat taggtcatct tttattagat gttttaattt
    25861 ggtttttgta gcaatttcaa caatacaact taaatctatt attctgtatt ttaaatctat
    25921 aacttcacaa tttttaaact taggcaagat tttttcgcca ggagttagga ttacagcatc
    25981 tgtgggagta aactcaatct ctggatagca gggcaggata tttatattgt ctattcctaa
    26041 tctatgtatt aaagaaattg tttctattgc catatcttta cttaagttat atacataaat
    26101 aattttatct ttttctaatt tggatatcat atcaatactg ttcttttcaa atgtcaactt
    26161 aggaacaatg atttgagcat catagtgaga taattttact atttcatcat attttaaata
    26221 agcagatagg agtataagtt tttctttaaa aaactttaaa tttccttctt caaatgagta
    26281 taaatttatc tttagattat cacctaagaa ttgtcttatt tgattttcat aaatttctcc
    26341 agcgtctttt tttaaactta caatag
//
LOCUS       DAEPID010000050        26253 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.050, whole genome shotgun sequence.
ACCESSION   DAEPID010000050 DAEPID010000000
VERSION     DAEPID010000050.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 26253)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 26253)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..26253
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.050"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            143..484
                     /locus_tag="KR257_002433"
     CDS             143..484
                     /locus_tag="KR257_002433"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015994381.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptide chain release factor-like protein"
                     /protein_id="HBH0031116.1"
                     /translation="MANIYCENYNCKNYFEDMCMLERIEINNFKECESYLEGKNELYE
                     LENGYTIHPKDLKMVKSKDYSVEVTHIPTGITVKCRSTNSILKNKNKCLEALEEELTK
                     INSHLELEDLR"
     gene            610..1017
                     /locus_tag="KR257_002434"
     CDS             610..1017
                     /locus_tag="KR257_002434"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009894734.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RusA family crossover junction
                     endodeoxyribonuclease"
                     /protein_id="HBH0031117.1"
                     /translation="MKVFLVIDGEPVGKERPRFNLATKRTYTPQKTKDYEELIKWLYQ
                     SKVRHYFTGYIKMTLRCYYSIAKSNSKKIKEQKRNNVLRPNKKPDIDNVVKIIADSLN
                     EIAYKDDTQIVEVVASKYYSDKPRVEVILEDVI"
     gene            1119..1967
                     /locus_tag="KR257_002435"
     CDS             1119..1967
                     /locus_tag="KR257_002435"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015994384.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ORF6C domain-containing protein"
                     /protein_id="HBH0031118.1"
                     /translation="MNENINKEITVLGTLEIEGMKFHNIEGGFGEHKKAMLVKDIAEI
                     HNRESRQINELINKNRKRFKDGKDILDLLGVGLDDTKIKELGFTQQSINSYRGLKNKG
                     LLSGIYILSERGYAKLLKILEDDIAWELYEKLVDGYFSMRKELNNPLLSASKELQAIF
                     MLDKKQEVLETKIENVNEKLENFMDDAPLFNIECECIVKEVKRVATKSLGGHGSKAYK
                     NKSLRGKVYSDIYHQIKREFGVDSYKAIKRCQLDKVLEIVNSYKLPIVFEEEIRLLNS
                     QLSIVS"
     gene            2110..2598
                     /locus_tag="KR257_002436"
     CDS             2110..2598
                     /locus_tag="KR257_002436"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009894737.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0031119.1"
                     /translation="MDNNINKKELFKKVEGRLHHYKFLSAEIKNLELDIESRENEIFG
                     CKAIGYGEKVSPTYAFNSTVENEIIKKERDIARLKKLKKDKEIEKKKIENALTCLDIR
                     EEHFFKLFYNSRMKNSMVYISLEMNSDRKTCRCVRERLVYKVMDMLYPRIKENELPLF
                     KN"
     gene            3180..3857
                     /locus_tag="KR257_002437"
     CDS             3180..3857
                     /locus_tag="KR257_002437"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015994390.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Bro-N domain-containing protein"
                     /protein_id="HBH0031120.1"
                     /translation="MLKILQEKNVKVMWSKNGEEVWFNANDVGEELGIVNIRDTLRNI
                     DREYKKKFNESTVGDSYTRNFKDKLPNFGTTFVTEEAVYNMSFRSNKPEAKLFTKWVT
                     KTLKQIRIHGYYIATEKDQEWLDIRTEGKKVRKDFTDEIQEFVYYATSQGSNKPQMYY
                     KHFTELVRKKLGIPKGVKRDELNQSELFDIQALERIISMKLPKLIDKDMNYKEVYKKI
                     KELIEMI"
     gene            3920..4621
                     /locus_tag="KR257_002438"
     CDS             3920..4621
                     /locus_tag="KR257_002438"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015994339.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0031121.1"
                     /translation="MQDVKEKVKQDYIKGMKQKEISAKYDISLNTLKSWIKRYNWASE
                     KKKGAPKNKRGAPIGNKNATGPPGNKNAEKFGFFSKYLPEETRELIQEISIKDKFDIL
                     WEQITIQYAAIIRAQKIMYVKDKEEMIKELKKHESTENGEKIEYEFQFAWDRQASFLN
                     AQSRAMSELRSLIKQYDEMIHKDWNLATEEQKNRVEKLKCEVDNLKKSDTGDDSKIWV
                     EAIQNIAMKRGVNNG"
     gene            4614..6023
                     /locus_tag="KR257_002439"
     CDS             4614..6023
                     /locus_tag="KR257_002439"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015994340.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DEAD/DEAH box helicase family protein"
                     /protein_id="HBH0031122.1"
                     /translation="MDKALLTLLDCYWDNPVWFAEDMLNFKADKWQSDVLMALAQTPK
                     VSIRSGQGVGKTGLESIATVWYLSTRPFPKVVATAPTRQQLYDVLWAEIAKWLSNSKV
                     EKLLEWTKTKVYMKGFEERWWATARTAVKPENMQGFHEDYMLFVVDEASGVADPIMEA
                     ILGTLSGAENKLLLCGNPTRTSGTFYDSHNRDRDLYKTFKVSSLDSPRTSKDNIEMLK
                     RKYHEGSDPWRVRVLGEFPKGESDSLISLEAVETSTIREVNISNDYILNIGADIARYG
                     DDETIIAPRIGGKVFDLLTYSKKDTMETVGNILRAVDKFKSMYHQINRVKIKTDDDGL
                     GAGVTDRLKEVIRQERLKYEIVPIQNGSSAIEKDKYYNKASEMWDNMREELDANLSGF
                     IQNKEAIIQLPNDDKLIKQLSNRKYTVDSKGKIQIESKKEMKKRIGESPDRADAVIYS
                     FAENNNTDLSLLKGGSVWG"
     gene            6014..7516
                     /locus_tag="KR257_002440"
     CDS             6014..7516
                     /locus_tag="KR257_002440"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015994341.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phage portal protein"
                     /protein_id="HBH0031123.1"
                     /translation="MGIISYVKKLFKRPTGEIMRMSSGNIGVYKLDDSRVDYELAREL
                     YQNKNANYKLGSSFVRPIVNSTTGFMGVPHFQIEDEEAQYILDEFVLDNTSKMLKTHT
                     DSLKQGDCYIWITREERENPLYPDKKVRLIYNFISPEEVKEIILDPTTKEPIAYILES
                     QNEWTDLEENKRRAKVKQIITAESRIIEVEGDKIEGLEEGETPNVWGFIPIIHFKNEA
                     DETLKYGQSDIEPIEPLLKAYHDVMLHALKGSKMHSTPKLKLKLTDVASFLAHNFGVE
                     DPVKFAKEGGKINLDGHEILFLNKDEEAEFVEVKSAIGDAKELLKLLFYCIVDVSETP
                     EFIFGVHTPSALASVKEQMPIMVNKIRRKREQFTNSWQLLARMVLIMSSNSSGMKYSS
                     YDVTIGWDEVNPRDDKELAETLEKVCSALDKALEGGFISEESTVNFLAQYIDTMSNYI
                     SDDPEIVGEREKIIKTKMLKYRLDDSQGLDDESNEIDKEIDKIKDNNDNG"
     gene            7509..8516
                     /locus_tag="KR257_002441"
     CDS             7509..8516
                     /locus_tag="KR257_002441"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015994342.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0031124.1"
                     /translation="MDKSTLELITVAGEYKKWALEARKKFIDLRLKQDDEIRTMYINI
                     TRNITKEIRKGNLSDFNKVRLKQILKQLTQEIKILNEQLVFNFDEYLNKNVETATSYS
                     KNILINAVETAQITKVTKAMIQKAFYDINIRTVEAYYTRVKDGLFLSDRIWSKCKKYR
                     EDMKVILQTAVTEGQDCVKTAKMLDKYVLKGKKTLVDEYPNMIKRIGNRVPQNISYEA
                     LRLARTEMTSAYGDGVLASAMINPATIGIQFMLSMAHPHTDICDEICGEDNFGLGKGV
                     YPINEAPAYPFHPHCLCIMLTVVQPLDILVGRLKNWIKNPMNDTPLEMWYQEVYGNLN
                     F"
     gene            8536..9870
                     /locus_tag="KR257_002442"
     CDS             8536..9870
                     /locus_tag="KR257_002442"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016056318.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0031125.1"
                     /translation="MNVITGEMDSMNALISSIKPSDIPLAKDIDIEALKSIDDDPLEV
                     VVEIPATKSKRGWNYTAKSLKDIVDYTNENTLNGFLGHQKAENISTEFAPPVTHWIGA
                     EMKGDKAYFRGLIDADATNLKRWIRTKRIKEVSIFGYPKLKKSAKGEMNVIGYEPLSI
                     DWTPLHRPGMPTSIVGMEMSPNGEQLDGTFEALRIDLREALKAKFSINDNNSYLYIQN
                     IRYDNNTVIYELEQNGLCKLYSIPFTIVENKINLGEEIEVIKKISYEAKGEMKGEENK
                     LEGKELIKNVKGLLQTGEISYSEVIQGIGLTKEIVTGEMEDVKSSLKAEKELREVKKV
                     LGIVGEMDTVEVAKKASKALENEKKEAWNCIVNKVIKDKVSGEIAQTLVKKMLNVEEG
                     SSEEVITGEIENILNDEFVKNTMSNMYKDNPTTTGLLNSSNNGSLTTKKNRI"
     gene            9886..10269
                     /locus_tag="KR257_002443"
     CDS             9886..10269
                     /locus_tag="KR257_002443"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015994344.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF2190 family protein"
                     /protein_id="HBH0031126.1"
                     /translation="MAFKGQPTPSTITQITRAKISDGKSVRVILSEGESTKTQQFYLI
                     NGFFGVAMQDGEKGDEVTLQIEQAEYETDNIVTSEAFEAGKLIYWDNTAKKFTTTSAS
                     NRLVGRVTDGKDSNNVIWFILLPQQ"
     gene            10288..11325
                     /locus_tag="KR257_002444"
     CDS             10288..11325
                     /locus_tag="KR257_002444"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015994345.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aspartate ammonia-lyase"
                     /protein_id="HBH0031127.1"
                     /translation="MAFKVISQENLLEQKRKETLQEDIPFIVNGEMEYVTKKISNGEM
                     ETLELNKPLGEMMTFSSTSNLKELLRKVVLDVELGREQVQLLYKPIYDSIADSNLPQV
                     MDAKWALQGNCVFLEHIEGEEIKFGTINAENGPVARIQTYATGFEYTKEMKDFNQTFS
                     VEILNKSIGESYNALLNHIHLSPIINFNYKASNKTAFKGETNDPIWLGIWRTLTQAQK
                     DTVIAKRQGNILMASSADQIEIEMALNGGHLLNGSMYPSIKNISTVIYYDGWEVTVGK
                     KTYSYKGVTPGKGYLIRPKRGFKELIKRDLTTEVGNADLSKLVENQIVGHCYRGAFAA
                     VEENVQEISFR"
     gene            11365..11703
                     /locus_tag="KR257_002445"
     CDS             11365..11703
                     /locus_tag="KR257_002445"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015994346.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0031128.1"
                     /translation="MTPTSNLIEKLRLLLNDKDKKSFTDEELNLFLEEADCIYCAASQ
                     GWVLKSLQYENTVGEMYEYKVGQETYKSSSIKDLVSVAYQNADKFKDMCTNKKEKGSF
                     MLGISTEFEI"
     gene            11700..12077
                     /locus_tag="KR257_002446"
     CDS             11700..12077
                     /locus_tag="KR257_002446"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016056320.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0031129.1"
                     /translation="MINIDRRRKDIIRTININPTNITITSIKKTEIDGAFEETETEIK
                     CVVRIFNEKTAEKQISSEKQGTFSSIRTYGMLVSDDVVLDVNSRDSLEFECIYGRMKI
                     VNVYPQIVKGELCGYQCSLERID"
     gene            12079..12489
                     /locus_tag="KR257_002447"
     CDS             12079..12489
                     /locus_tag="KR257_002447"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017752519.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0031130.1"
                     /translation="MSAFTNAINDINRKKAGMFVLCMSASAMLEGEAKANARWTDRTS
                     HARQSLNAKTLSGGNNFIIRLSHGAEYGGILEEGSKPHVITPKSAQALYWRGASHPVK
                     SVQHPGTKAMPIIKPTIDKNIGKIGNMIFRYWSD"
     gene            12490..13311
                     /locus_tag="KR257_002448"
     CDS             12490..13311
                     /locus_tag="KR257_002448"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016056322.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0031131.1"
                     /translation="MRAGIRKALIDNIKELKGCYEPNVPNKDTKKPYMVVVQGQDNDN
                     GETIGFERSIEVWIYEGRTTFKKLDKLTKQVIEILDMNTIVDESENEAFTCIYKGTSE
                     NDIVVEEWDAIARGIRFSVIALEDKEDTTNDRWVEALSRHTKDLLEIESYKDNWKKNF
                     IAPCALWRTTHIENKRINYHLIEITKTMKCHVVSKNKDEIVKLLETLETSLIIDKRVR
                     LREDKNMYLTLVSVVEDRESDMFTTGQLTAVFKMIGKIKREGPTMDKIYGNGNLR"
     gene            13324..13527
                     /locus_tag="KR257_002449"
     CDS             13324..13527
                     /locus_tag="KR257_002449"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015994350.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0031132.1"
                     /translation="MAETNNKKINVSKQEEKYLKSDFIENSEALGYKKEVVAGALFNC
                     KKEELTKSEFEKAIKEFLEREVK"
     gene            13529..14950
                     /locus_tag="KR257_002450"
     CDS             13529..14950
                     /locus_tag="KR257_002450"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015994351.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phage tail sheath subtilisin-like
                     domain-containing protein"
                     /protein_id="HBH0031133.1"
                     /translation="MATGTWNEKEKKEIPGFYNRFKTQAEKSTNTGLKGRLAMPIRAN
                     WGEVGKVVTIKNDLRQLKTLFGDDMNYSAFKLGKLALLGNVKELLLYRLVDGNQKKGT
                     LTLKDTTENSAKDVIKLETKYPTSRNFNVTIKSNLVDADKKDFIFFEGTKQLFSSSVK
                     GTIDEIVLEINSNLDNEYVIATKVADSDTALANLVNVALEGGNDGCTSITNESYLKAL
                     EEFERYSFDSFVLDGVAEEALQETTKAWVAKNKELGKDILLFLGGKAEDNIKQINDKS
                     KSFNDENIVNVGSSAYYEGIKYTPSEVAVYIAALSVSKGITGSICNAKTIFEEVEPRL
                     SQSEVKECLKSGTLILDFDDGDVIIVDDVNTFKKYVDDKNEAIGYISNIMFINTINKD
                     TSLKRKEFVGKIFNDSTGQTTVICALKKYFEELMGQGIISEFNVDIDTELQATAKADE
                     FYWKWDAVKVDVMKKIFGTGYLG"
     gene            14966..15388
                     /locus_tag="KR257_002451"
     CDS             14966..15388
                     /locus_tag="KR257_002451"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015994352.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0031134.1"
                     /translation="MGKYDENIIDAANVADGSNAKIIVDGKEEGYGTEFTAEVENDKK
                     TFRVIGCKWELNKASTQKGTFSLTVLKTTSEWIERGFDKFELISEIENPGLVGYERIR
                     YKNCMVDKIQLASIKADENIEIQIDGTFEGYELVDKIA"
     gene            15467..15940
                     /locus_tag="KR257_002452"
     CDS             15467..15940
                     /locus_tag="KR257_002452"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015994353.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0031135.1"
                     /translation="MANLDKEFLNEGIEEERELTKEEIAKQQEDNIIMKLTEDAILPE
                     KTIFVKRLDIPLTLRALTEKEISALQKKYTKVTKVRGRRESKLMEDEFNIALIEKATI
                     VPNFCDARLLNSMNVSSGVEFIRRKFLAGEIALISDEVLELSGFYEELSDDDIKN"
     gene            16121..20449
                     /locus_tag="KR257_002453"
     CDS             16121..20449
                     /locus_tag="KR257_002453"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015994354.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phage tail tape measure protein"
                     /protein_id="HBH0031136.1"
                     /translation="MREIAKKEMYHIDVVIDVTGDEQTKNKLSAMERYTKQTEKRMRA
                     LNRIKANPVIQAQDKTSSVVNRISNNLKRVGRTISTTINAKDRASSVVNRVKNKVNSL
                     LTSRQREVLLKARDKASQVVDKVKAKVQNLTAATIISLNMKADPALRVISQTRSKLGE
                     LKNNTIINIKAKGEEALNTISRTKSKLQEFSNRTYQAIVKLKDEASPTLSGLDGKISS
                     FISSTISKFTQLAVTATALIGGVGVGSAIKGFADFEQAMKNAQAVSSANSKEMAEMTA
                     MAREMGRTTSFTAKDAGNAMYFMGMAGWKSKEMIAGLPGILNLAATGQTDLALTADIV
                     TDGLTALGLTAKDTGMFVDVMAATVTNSNTDIERMGETFKYMGSVGGALGVSMKDLSL
                     ATGLMASASVKGSMAGTALRGGLVRLIKPPAEAQKAMNKYGIEIKKTKDGNLDLASTI
                     VDLREKLGGLEGVQKSAAISSIFGRTAMAGWAAVVNASEKDFKKLTTAINESEGEAKR
                     IADMKLDTLSGQFEILKSAIDDVRISVGQRLGPMTRSFVEQLTKDMPKIGDAIVSFVS
                     DFINDFDKIKSIMQNVISVISGIVSAFIAFKALKFISFLIPILSDIGFAIAAFAGGAA
                     TLGEALLFALGGPVGAVIAGVVLLATAFTLAYQKSDAFRKIVKNVGKSIKNFLQEAII
                     AISPFVNVFGNKLKELGKAVIPLLKVFGDFASTLMSKIGPIILFLSSNVLAGFILTFV
                     AAVEAVKSAVVAITGVLQGLTSIIKGVFDIVGGIISGDGKQIINGLKSVFEGGIKIVS
                     SVWKGLVDIVTSPIQAVVDVLDEKFGKKVEGIKKKWNELKDFLKNPTKAAPKVQPVNL
                     SGEKASNELQASSNGAKAYISSLGQKIGEGIGKIKDKFGELKISATEVFNNIVSFVGG
                     KATELKDKLLEGIKPAIDTFKQSLSNLKEVFGDSLDSIKEAFGGLKTVFDENIKTPFE
                     NLKQKVLETKESLKPVFDNLKSSFAELGKALEPIKEAFSGIKDFFSNLFKPIKDDGAT
                     KTTKTNMDELKQSTQRVGTSFKELGNAFNQLKEAAKPFIDYLKQIKDSLTSTLGDIGG
                     GLLKGVATSIVLVITSVINAIASIINAVAGAIKGVIDIIKGIFEIIGGIISGDGEKIK
                     QGFSDVFKGIGEVVKSLWEGIKGVLGAPLKAVVNFIDNGFSEKVGQVKQWWSDLKTNV
                     GQKISGFVSFVSNGFQQKVQQVGMWWQGLKVNLSGKISGFVSLVENGFKSKVDSIKSA
                     WDSLRKKLSQKITGFVSIVKTGISNVLDRFADGGVASKPSICGEAGPEMVIPLSNSKR
                     SRALSLYEQAGQMLGTKASNNVIPISQKLGTSFNSASSIQNSNSSIINNVRQFPTKQE
                     EFNNTENRIYQEAQPQNIISSGSNAINVGGISINIQGSNNKEEMIQEILSQVESGLRE
                     ALEDIG"
     gene            20529..21323
                     /locus_tag="KR257_002454"
     CDS             20529..21323
                     /locus_tag="KR257_002454"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0031137.1"
                     /translation="MWGRFKNMSIILKVLVLVCAIAIFPITLLAFSIEFVVKSFKRNE
                     RFKVVFGVFLVFITFSFVCIWYLLEDNITTSNSSNKKQEEHLKEEPGKNLATREAEEE
                     TNKKKEQEKQKNEGTEAEKKERDKTEKKEKVDKKYQEKNKEKAETKKQTLTSEELKKK
                     VDSIIPAEYKGNYYTNDVLDTDGSYVLSLQVQNASFDNESSCKAFTKDLINKLKEFRI
                     DSAEVYFVGSSGQTTYQINIDDFLKVQDNIKSVDNMEFFSFKDFKN"
     gene            21393..22064
                     /locus_tag="KR257_002455"
     CDS             21393..22064
                     /locus_tag="KR257_002455"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016056330.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LysM peptidoglycan-binding domain-containing
                     protein"
                     /protein_id="HBH0031138.1"
                     /translation="MVIDIYLKNEKEKIDFHFPVNPFDSLSIKKEKRFETVDIVNLGE
                     FDIKKEGEKIREISFKTFLPNLYDASYCRYSELKNPIEVVAMLEKWVDQAEPLRLIVT
                     GFGYNGLVTISNFSNTQTAGREEDRDIEITFRTYRELKIETLKKDTKSNTKTDLKDNR
                     PNTQTKSKIYTVKASDTLYKIAKNLLGKGSRWPEIYNIPENKKVIGKNPNIIKKGQKL
                     VIPSK"
     gene            22061..23023
                     /locus_tag="KR257_002456"
     CDS             22061..23023
                     /locus_tag="KR257_002456"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015994357.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="XkdQ"
                     /protein_id="HBH0031139.1"
                     /translation="MKIILNGKYDIANFNEGITLSEAIDGVAYKMDVSLVEPKQLKDI
                     NIKKGDKIILIDIAYESKKEETIFDGVVWETRRSEKSKKLTLSCRERTVYMEESEEQY
                     QFKENTATQRIEYYCKQWNIPYYNLANTGKKLAKVIHKTNILDMIKKDLKETATKGGD
                     LFRVRMDNKLKLFKLGTNANVYKLDSILEDANFTSSFNDAVTSVKVLGKSKDENTKAP
                     IIGTYKKDADKFGTLQKIKQDEKIKNAKEAKKAAEAMFNSGEETISVDCAVDINRIRA
                     GDKVSLKSKEYYVIDVTHTLDSRPKMKLNIGSLEYIRRKFYNND"
     gene            23016..23381
                     /locus_tag="KR257_002457"
     CDS             23016..23381
                     /locus_tag="KR257_002457"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015994358.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0031140.1"
                     /translation="MTDARFNGIARILKENMNKSVANGTFGMGCELAEITANGLKVNG
                     YKDEIQDYLVLENLTLKEDYFTFSDEALSGEYRHKHKIETPKELKPLRIGDNVLVAVM
                     GAEFVVIGRVVNAKPISSK"
     gene            23356..23814
                     /locus_tag="KR257_002458"
     CDS             23356..23814
                     /locus_tag="KR257_002458"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016056333.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF2634 domain-containing protein"
                     /protein_id="HBH0031141.1"
                     /translation="MPNLFPQSETFETVELKNNDENELDLKGSFLFDFEKGEFVKNAD
                     GTLKKCDKVQAYKQWCQKAILTPRYKKAAYTNIYGSEIKDLIASNLSQSAKELEITRL
                     IKETILVHPYTKEVSNFIFVWLENSRLVNYEFDVLTIDDENITIDGNIKR"
     gene            23823..24959
                     /locus_tag="KR257_002459"
     CDS             23823..24959
                     /locus_tag="KR257_002459"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016056334.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="baseplate J/gp47 family protein"
                     /protein_id="HBH0031142.1"
                     /translation="MERELPIPLFLTEEEDSVHERMLSNFQDVSTLEGDFIYDATRPT
                     AEQIAELKQLGLQNNLRIAFPQTSYGEYLEWLGECKGVFKNQPTKSVGMVTFNGAQGT
                     IITKGTIVTTIATDEKQSIEFELLETKTIGANETVDIKAECRIAGTIGNVSNNTITVL
                     LGSISGVKSVSNKEDFRGGTDIEDEEHFRERVLVAEQEDKLSGASSDYIRWAKEVDGV
                     GYAYVVPEWNGAGTVKVLILDKNRKAATQELIDKVQEYIYPLNISEGENRDGKAPIGA
                     LVTVVTPDTLLINVKASFIFSNGFSEETVLNNLKTKIDKYLDKIDLGGTVSYNAIQAI
                     VGSMMLTDEGIEDFSNLTINDVKENIKLQDQVVGIGEIVNEVVG"
     gene            24956..25585
                     /locus_tag="KR257_002460"
     CDS             24956..25585
                     /locus_tag="KR257_002460"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016056335.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YmfQ family protein"
                     /protein_id="HBH0031143.1"
                     /translation="MIASKKGKEMLLTLSPIYEQSIIMQSLYEAIGSEFDNLELLNKE
                     IELQLFPQSATWGLEFWENRVGLSTNIDEDIEARRRKVIAKLQSKYIMTPKRMAMILQ
                     SYTGANIKINENISPYTFGVELTSTQGFPKDLEDLYKRVNVIKPSHLAVSYKLVSLLK
                     SKTYFAQTAIMSEEITVYPYTSKEVKASVKAKFALAHNMSSETLTVYPR"
     gene            25598..>26253
                     /locus_tag="KR257_002461"
     CDS             25598..>26253
                     /locus_tag="KR257_002461"
                     /inference="COORDINATES: protein motif:HMM:NF023985.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009894901.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phage tail protein"
                     /protein_id="HBH0031144.1"
                     /translation="MADEQFYTILTNIGKAKIANAGMLGKSVILEKIQAGDGGGNYYN
                     PTEDQTALKNKVWEGNINAFDNDENNPNWIIATACIPGSIGGFTVREMGLIDNEGDMI
                     AVCKSPETYKPKVDNGAMKDLYLKFIIEVSNVEKVTLVVDPTAIFLTKKDEEKILTNI
                     NKLDTKIDTTKTELTSNIETTKTELNTRIDTENEKQNIKIDQLIAGGSNVASTQIITI
                     "
BASE COUNT        10834 a         2859 c         5151 g         7409 t
ORIGIN      
        1 gatgcaaata caaagaaaat atggataaag tatgtgaaga gaactataag aaattaagaa
       61 gtaaatagaa taaaatagtc aaggtaagtt tgtgaatgaa actagaatgt tataggcttg
      121 acttataaaa ggagtgcgtt aaatggctaa tatatattgt gaaaattata attgtaaaaa
      181 ctactttgaa gatatgtgta tgcttgaaag aattgaaatt aataacttca aagaatgcga
      241 aagctatctt gaaggtaaaa atgagctata tgaattagaa aacggatata ctatacatcc
      301 taaagatttg aaaatggtga aaagtaaaga ttattctgtt gaagttactc atattccaac
      361 tggtattaca gtaaaatgcc gttctacaaa tagtatttta aaaaataaaa ataagtgttt
      421 ggaagctcta gaagaagaac taacaaaaat aaactctcac ttagagctag aagatttacg
      481 ctaaatagga agtgagctta tgaaacgaag aagatgcagt tggtgtggta agttatttta
      541 tcttgaagaa aaatctaagg atgtttattg ttgtaaagaa tgtaggaaga aggctaagaa
      601 ggtgaaaaaa tgaaagtttt tcttgtaata gatggagaac cagttggtaa agaaagacct
      661 agatttaact tggctactaa aaggacctat acaccacaga aaactaagga ctatgaagaa
      721 ttaataaaat ggttatatca atctaaagtt agacattatt ttactggata cataaaaatg
      781 actttaagat gttattactc tatagcaaaa agtaacagta aaaagattaa agagcagaaa
      841 agaaataatg tgttaagacc caataaaaaa ccagatattg ataatgtggt caagattata
      901 gctgattcac tcaatgagat agcttataaa gatgatacgc agattgttga ggttgtagct
      961 agtaaatatt acagtgataa accaagagtt gaggttatat tagaagatgt tatttaacca
     1021 acggaaaaat ccgttcgtta gattaggtac tcagtttttc ataaaaatgt gaaaaagctg
     1081 aatagagaat atatcaaatg gtaaaggaga gataaattat gaatgaaaat ataaataaag
     1141 aaataacagt acttggaact ttagaaatcg agggaatgaa atttcataac attgagggtg
     1201 gatttggaga acataagaaa gcaatgctag taaaagatat agctgagata cataatagag
     1261 aatctagaca gattaatgag cttataaata agaatagaaa aagatttaaa gatggaaaag
     1321 atatattaga tttgttaggt gtcggtttgg acgataccaa aataaaagaa ttaggattta
     1381 ctcaacaatc aattaattct tatagagggt taaaaaacaa agggttatta tctgggattt
     1441 atatattatc tgaaagaggt tatgcaaaat tattaaaaat attagaagat gatatagctt
     1501 gggaattata tgagaagtta gttgatggat atttctctat gagaaaagaa ctaaataatc
     1561 ctcttttaag tgcatcaaag gagttacaag ctatatttat gctagataag aaacaagaag
     1621 tcttagaaac taaaatagag aatgttaatg agaagttaga gaactttatg gatgatgcac
     1681 cattattcaa tatcgagtgt gagtgtattg ttaaagaggt taagagagta gcaacaaaat
     1741 cacttggtgg acatggaagt aaggcttata aaaataaatc tttaagaggt aaagtttata
     1801 gtgatatata ccatcagatt aaacgagaat ttggagtaga tagttataag gctataaagc
     1861 gttgtcaatt agataaagta ttagagattg taaatagtta taagttacct atagtgtttg
     1921 aagaagaaat aagacttttg aatagtcaat tatcaattgt gagttaagac aggaatagat
     1981 ttttctcctt taaaggggaa aacctgcaat agttaattaa aagagaaaag gagtgctttc
     2041 acactccact tgtcaaaaat ataaagcttt tatccaagat tattataaca taaacaggag
     2101 tgtgaaagta tggataataa tattaataaa aaagaactat ttaaaaaagt agaaggtaga
     2161 ctacatcatt ataaattttt aagtgcagaa attaaaaatc ttgaattaga tatagaaagt
     2221 agagaaaatg aaatatttgg ttgtaaggct atcgggtatg gtgaaaaagt aagtccaaca
     2281 tatgctttta attcaactgt tgagaatgag attataaaaa aagaaagaga tattgctaga
     2341 ttaaaaaaac tgaaaaaaga taaagaaata gaaaagaaga aaatagaaaa tgcacttaca
     2401 tgcttagata taagagaaga acattttttt aaactgtttt ataatagcag aatgaaaaat
     2461 agtatggttt atatatcctt agaaatgaac tcagatagga aaacatgtag atgtgtaagg
     2521 gaaagattag tgtataaagt tatggatatg ctttatccaa gaattaagga aaatgaactc
     2581 ccattattta aaaattagaa aattccccag tttttcccca gaaattccca ctttattccc
     2641 tactttctcc ccgttttgat taaaaaagca tgagataata gtattgtgga aataaagatt
     2701 tccctctcaa aacttaatat ttgactaggg ttaagggatt gccctagtca ctatgaacag
     2761 actaggcagg gcatgaggat gctgttagtt caattctaac tatgttcaat ctttagtttt
     2821 tctatttcaa ttaatctacg gatacactaa aaaatagtat atgaattgag attaaaatct
     2881 catacaattt tgtatcttaa ttcaaagact aaaaaccgag tggggcttgg taacctcact
     2941 caccatgcaa gtactggttt aatctaggtt cgattcctgg aacttgctcc ctttaataat
     3001 atgtatcccc cattaaaaag gcttagatta acttctaggt cttttttaat acaaaaattt
     3061 attaaaaatg cacggcatgc actattcaga tatgcatgtc atgcatgtct aaagtcgaat
     3121 atttaatatt ttcgatggct caaattgagg ggtcgaaaat aaaaacagga ggtagtagta
     3181 tgttgaaaat tttacaagag aaaaatgtaa aagtaatgtg gtccaaaaat ggagaagaag
     3241 tttggtttaa tgcaaatgac gtaggagagg aactaggcat agtaaatatt cgtgatacat
     3301 taagaaatat agatagagaa tataaaaaga aatttaatga gtctactgtc ggagattcct
     3361 acactagaaa ctttaaagat aaattgccta acttcggtac tacttttgtt acagaagaag
     3421 ctgtgtacaa tatgtcattt agaagtaata aaccagaagc aaagttattt acaaaatggg
     3481 ttacaaaaac acttaaacaa attagaatac atggttatta tattgctaca gaaaaagacc
     3541 aggaatggct ggatataagg acagaaggca aaaaagtaag aaaagatttt acagatgaaa
     3601 tacaagagtt tgtatattat gctactagtc aaggtagcaa taaacctcag atgtattata
     3661 aacattttac tgaacttgta agaaaaaaat taggtattcc aaaaggtgtg aaaagagatg
     3721 agttaaatca aagcgaacta tttgatatac aagcacttga aagaattata tctatgaaat
     3781 tacctaagtt aatagataaa gatatgaatt ataaagaggt atataaaaag attaaggaat
     3841 taatagaaat gatttaaggg actgtcttga tggagggtct tttttaattc ccaaaacgac
     3901 aaacaaacga ggtggtgatg tgcaagatgt caaagaaaag gtaaaacaag attacataaa
     3961 aggtatgaaa caaaaggaaa tatcagcaaa gtatgacatt agtttaaaca ctttaaagtc
     4021 atggataaaa agatacaatt gggctagtga gaaaaagaag ggtgcaccta aaaataaaag
     4081 aggtgcaccc ataggtaata aaaatgccac tggtcctcct ggaaataaaa atgctgaaaa
     4141 gtttggtttc ttctcaaaat atctacctga agaaactagg gaattaatac aagaaatatc
     4201 tataaaagat aaatttgata ttctttggga acagataaca attcaatatg cagcaataat
     4261 aagagcacaa aagataatgt atgttaaaga caaggaagaa atgattaagg agttaaagaa
     4321 acatgaaagc acagaaaatg gtgagaagat agagtatgaa tttcaatttg catgggatag
     4381 gcaagcatct tttcttaatg cacagagtag ggctatgagt gagttaagga gtttaattaa
     4441 acagtatgat gaaatgattc ataaggattg gaatttagct acagaggagc agaaaaatag
     4501 agttgaaaag ttaaaatgtg aagttgataa cctaaagaaa agtgatactg gagatgattc
     4561 aaaaatttgg gttgaagcta tacaaaatat tgcaatgaaa cgtggtgtta acaatggata
     4621 aagctttatt gacactatta gattgttatt gggataatcc tgtttggttt gcagaggata
     4681 tgttaaattt taaagctgac aagtggcaat ctgatgttct gatggcttta gctcaaaccc
     4741 caaaagtatc tattagaagt ggtcaaggag taggtaaaac tggattagaa agcattgcaa
     4801 ctgtatggta tttaagcact agaccttttc cgaaagtagt tgctacagct ccaacacgac
     4861 aacaattata tgacgtacta tgggctgaaa tagctaaatg gctaagtaat agcaaggttg
     4921 agaagctact tgagtggact aaaacaaaag tgtatatgaa aggctttgaa gaaagatggt
     4981 gggctacagc tagaacagca gtaaagcccg agaatatgca aggttttcat gaagattata
     5041 tgttatttgt tgttgatgaa gcttcgggag ttgctgaccc cattatggaa gctatattgg
     5101 gaacattatc aggtgcagaa aataagcttc ttttatgcgg aaacccaact agaacgagtg
     5161 gaacgtttta cgatagccat aatagagaca gagatttata taaaacattt aaagtatctt
     5221 ctttagatag ccctagaaca tcaaaagata atattgaaat gctaaaaaga aagtaccatg
     5281 aaggttctga cccttggcgt gttagagttc ttggagaatt tccaaaaggt gaaagtgatt
     5341 ctttaatatc tttagaagct gttgaaacaa gcacaataag agaagtgaat atatctaatg
     5401 actatatatt aaatataggt gcagatatag caagatatgg tgacgatgaa actataatag
     5461 ctccacgaat aggtggaaaa gtgtttgatt tattaactta ttctaaaaaa gacacaatgg
     5521 aaactgtagg aaatatatta agagcagttg ataaatttaa aagcatgtat catcaaatca
     5581 acagagtaaa aataaaaacg gatgatgatg gtttgggtgc aggtgttaca gacagattaa
     5641 aagaggttat aagacaagaa agactcaaat atgaaattgt acctattcaa aatggttcta
     5701 gtgctataga aaaagataaa tactataata aagcttctga aatgtgggat aacatgaggg
     5761 aggaattaga tgcaaattta agtggcttca tacaaaataa agaagctata atacagcttc
     5821 ctaatgatga taaacttatt aagcaactat caaatagaaa atatacagta gattcaaaag
     5881 ggaaaataca aatagaaagt aaaaaggaaa tgaaaaaaag aattggagaa tcacccgata
     5941 gagctgatgc agtaatatat tcgtttgcag aaaataacaa tactgattta tctttactga
     6001 aagggggtag tgtatgggga taatatctta tgtaaaaaag ctatttaaaa gacctactgg
     6061 agaaattatg cgtatgtcta gtggaaatat aggcgtatat aaattagatg attctagagt
     6121 tgattatgag ttagcaagag aattgtatca aaacaaaaat gctaattata aattaggttc
     6181 tagttttgtt agaccaattg tcaattcaac aactggtttt atgggtgtac ctcattttca
     6241 aatagaagat gaagaagctc aatatatatt agatgaattt gttttagata acacatctaa
     6301 aatgttaaaa acacacacag atagtttaaa gcaaggtgat tgttatattt ggataactag
     6361 agaagaaaga gaaaatcctt tatatcctga taaaaaagtt agattaatat ataacttcat
     6421 atcacccgaa gaagtgaaag aaataatatt agaccctacg acaaaagagc ctatagctta
     6481 tatattagaa agccaaaatg aatggactga cttagaagaa aataagagaa gggctaaggt
     6541 aaaacaaata ataactgctg aaagtagaat tattgaggtt gaaggggata agatagaagg
     6601 tttagaagaa ggggaaactc ctaatgtatg gggctttata ccaataatac attttaaaaa
     6661 tgaagctgat gaaacattga aatatggtca aagtgatata gaaccaatag aacctctttt
     6721 aaaagcttat catgatgtta tgttacatgc gttaaaaggt agcaaaatgc actctactcc
     6781 aaaactaaag ctgaaattaa ctgatgttgc aagtttctta gcacacaact ttggtgttga
     6841 agacccagtt aaatttgcaa aagagggtgg aaagataaat cttgatggac atgaaatact
     6901 attcttaaat aaagatgaag aagctgagtt tgtagaagta aaatcagcta taggtgatgc
     6961 taaggagctt ttaaagcttc ttttttattg catagtagat gtatctgaaa cacccgagtt
     7021 tatatttgga gtacatacac ctagtgcttt agcttctgta aaagaacaaa tgcctattat
     7081 ggtaaataag ataagaagaa aaagagaaca atttacaaat agctggcaat tacttgcaag
     7141 aatggtttta ataatgagtt ctaattctag tggtatgaaa tattcatctt atgatgtgac
     7201 tataggttgg gatgaagtaa atccgcgtga tgataaagaa ttagctgaaa cactagaaaa
     7261 ggtatgtagt gcattagata aagctttaga aggtggattt attagcgaag aatcaacagt
     7321 aaacttttta gctcagtata tagatacaat gagcaattat ataagtgatg accctgaaat
     7381 agttggagaa agagaaaaga taataaaaac taaaatgtta aaatacagat tagatgattc
     7441 tcaaggttta gatgatgagt caaatgaaat tgacaaggaa atagataaaa taaaggataa
     7501 taatgacaat ggataaaagt actttggaat taataactgt tgcaggggag tacaagaaat
     7561 gggcattaga agctagaaaa aaatttatag atttaagact caagcaagat gatgaaataa
     7621 gaacaatgta tattaacata acaagaaata ttacaaaaga aataagaaaa ggaaatcttt
     7681 cagactttaa caaagttagg ttaaaacaga tactaaaaca attaacacaa gaaataaaaa
     7741 tattaaatga acaactagta tttaattttg atgaatactt aaataaaaat gttgaaacag
     7801 ctactagtta ctctaaaaat attttaatta atgcagttga gacagctcaa ataactaaag
     7861 taactaaagc tatgatacaa aaagctttct atgatattaa tataagaact gtagaagctt
     7921 attatacaag ggttaaggat ggtttatttt tatctgatag aatttggtct aagtgtaaga
     7981 agtacagaga agatatgaaa gttatattac aaacagcagt aacagaaggt caagactgtg
     8041 ttaaaacagc taagatgcta gacaaatacg ttttaaaagg taagaaaact ttagttgacg
     8101 aatatccaaa tatgataaaa agaataggaa atagagtacc tcaaaatata agttatgaag
     8161 ctttaagatt ggcaagaact gaaatgacat cagcttatgg tgatggggtc ttagcttctg
     8221 caatgattaa ccctgcaacc ataggtattc agtttatgtt gtccatggca catcctcata
     8281 cagatatatg cgacgaaata tgtggagagg ataattttgg tttgggtaaa ggtgtttatc
     8341 ctataaatga agctcctgca tatccattcc accctcattg tttgtgtatt atgcttactg
     8401 tagttcaacc attagatata ttagttggaa ggttgaaaaa ttggattaaa aatcctatga
     8461 atgatacacc tcttgaaatg tggtatcaag aggtgtatgg aaatttgaat ttttaaattg
     8521 aaaggtggtg attaaatgaa tgtaataact ggagaaatgg actcaatgaa tgcgttaata
     8581 tctagtataa aaccttctga tattccttta gctaaagata tagacataga agctttaaaa
     8641 tctatagatg atgaccctct tgaggtagtt gttgagatac cagctacaaa atctaaaagg
     8701 ggatggaact atactgctaa aagcttgaaa gatattgtag attacactaa tgaaaatact
     8761 cttaatggtt ttttaggaca tcaaaaagct gaaaatatat caactgaatt tgcaccacct
     8821 gtaacgcatt ggataggtgc agaaatgaaa ggggataaag cttatttcag aggactgatt
     8881 gatgctgatg caacaaactt gaaaagatgg attagaacta aaaggataaa agaagttagt
     8941 atatttggtt atccaaaact taaaaagagt gctaaaggcg aaatgaatgt tataggatat
     9001 gagccactat ctattgattg gactcctcta catagaccag gtatgccaac aagtattgta
     9061 ggtatggaaa tgagtcctaa tggcgaacag ttagatggaa cttttgaagc tttaagaata
     9121 gatttaagag aagctttaaa agctaagttt tctattaatg ataataattc atatctctat
     9181 atacaaaaca taagatatga taacaatact gtcatatatg agttggagca aaatggatta
     9241 tgcaagcttt atagtatacc atttactata gttgaaaata aaataaatct aggtgaagaa
     9301 attgaagtaa taaagaaaat aagctatgaa gctaaaggag aaatgaaagg agaggaaaac
     9361 aaattggaag gaaaagagtt aataaaaaat gtcaaaggat tactgcaaac tggtgaaata
     9421 tcatattcag aggtcataca aggaataggc ttaactaagg aaattgtgac aggagagatg
     9481 gaagatgtaa aaagttcatt aaaagcagaa aaagaattaa gagaagtgaa aaaagtactt
     9541 ggaatagtag gagagatgga cacagttgaa gtggcaaaaa aggcttcaaa agctttagaa
     9601 aatgagaaaa aggaagcttg gaactgtata gttaataaag taattaaaga taaagtgtca
     9661 ggtgaaatag ctcaaacatt agttaagaaa atgttaaatg ttgaggaagg ctcaagtgaa
     9721 gaagtaataa caggagaaat agaaaatata ttaaatgatg agtttgtaaa aaatacaatg
     9781 tctaatatgt ataaagataa tccaacaaca acaggattat taaactctag caataatgga
     9841 agtttaacaa ctaagaaaaa tagaatataa aggagtgatg tttatatggc atttaaaggt
     9901 caaccaacgc caagcacaat aacacagata acaagagcaa aaataagtga tgggaaatct
     9961 gtaagagtta ttctttcaga aggtgaaagc actaaaacac aacaatttta tcttataaat
    10021 ggattctttg gagtcgctat gcaagacgga gaaaaaggcg atgaagttac tttgcaaata
    10081 gagcaagctg aatacgaaac ggataatatt gttacatcag aagcttttga ggcagggaaa
    10141 ttgatttatt gggataatac agctaagaaa tttactacta catctgcaag taataggcta
    10201 gttggtagag taacagatgg gaaagacagt aataatgtaa tttggtttat attattacct
    10261 caacaataga aaaggagtga taaatatatg gcatttaaag taattagtca ggaaaatttg
    10321 ctggaacaaa aaagaaaaga aactttacaa gaagatatac catttatagt aaatggtgaa
    10381 atggaatatg taacaaagaa aatatcaaat ggagaaatgg aaaccttgga gttaaataag
    10441 ccacttggtg aaatgatgac ttttagctcg acttcaaatt taaaagagtt attaagaaaa
    10501 gttgtattag atgttgaact aggcagagag caagtacaac tattatataa accaatctat
    10561 gacagtatag cagattctaa tttaccacaa gttatggatg ctaagtgggc tttacaaggt
    10621 aactgtgtat tcctagagca tatagaaggt gaagaaatta aattcggtac aataaatgca
    10681 gaaaatggtc cagttgcaag gatacaaact tatgcaactg gttttgagta tacaaaagaa
    10741 atgaaggatt ttaaccaaac atttagtgtt gaaatattaa ataaatcaat tggtgagagt
    10801 tacaatgcct tgttaaacca catacatcta agcccaataa taaattttaa ttataaagct
    10861 tctaataaga cagcttttaa aggtgaaact aatgacccaa tatggctagg aatttggaga
    10921 acattaacac aagcacaaaa agatacagtt atagcaaaaa gacaaggtaa tatattaatg
    10981 gcttctagtg ctgaccaaat tgaaatagaa atggcgttaa atggaggaca tttattaaac
    11041 ggaagcatgt atccatctat aaaaaatata tcaacagtaa tttattatga tgggtgggag
    11101 gttactgttg gtaaaaaaac atattcttac aaaggtgtta caccaggcaa aggatatttg
    11161 ataagaccta agcgaggatt taaagagtta ataaagagag atttaacaac agaggttgga
    11221 aatgctgatt taagtaagtt agtagaaaat caaattgtag gtcattgtta tagaggtgct
    11281 tttgcagcag tagaagaaaa tgtacaagaa ataagtttta gataaaacac tcataagagt
    11341 gttattttta tgaggtgata atatatgaca ccaactagta atttaataga aaaattaaga
    11401 ctattattaa atgataaaga taaaaaatca tttacagatg aagaattaaa cttgttttta
    11461 gaagaagcag actgtattta ctgtgcagct tctcaaggat gggtattaaa atctttacaa
    11521 tatgaaaata cagtagggga aatgtatgag tataaagtgg gtcaagaaac atataaaagc
    11581 tctagtataa aggacctagt atctgtagct tatcaaaatg cagataaatt taaggatatg
    11641 tgtactaaca aaaaagaaaa gggaagtttt atgttaggaa ttagcacaga atttgaaata
    11701 tgataaatat tgatagaaga agaaaagata taataagaac tattaatata aaccccacta
    11761 atattactat aactagtatt aaaaaaaccg aaatagatgg agcttttgaa gaaactgaaa
    11821 cagaaataaa atgtgttgtt agaatattta acgaaaagac agcagagaag caaatatcaa
    11881 gtgaaaagca aggtacattt agttctatta gaacatatgg aatgttagta agtgatgatg
    11941 ttgtcttaga tgttaacagt agagattctt tggagtttga gtgcatatat gggagaatga
    12001 aaatagttaa tgtatatcct caaattgtaa aaggagaact ttgtgggtat caatgttcac
    12061 ttgaaaggat tgattaaaat gagtgctttc acaaatgcaa taaatgatat aaatagaaaa
    12121 aaagcaggta tgtttgtact ttgtatgagt gcaagtgcaa tgctagaagg tgaagctaaa
    12181 gcaaatgcac gttggacaga tagaacatca catgcaagac aaagtttaaa tgctaaaaca
    12241 cttagtggag gaaataattt tatcattaga ttatctcatg gtgcagaata tggagggata
    12301 cttgaagaag gctcaaaacc acatgttatt actccaaaat cagctcaagc cctatactgg
    12361 agaggtgctt cacatcctgt aaaatcagtt caacatcctg gtacaaaagc aatgcctatt
    12421 ataaaaccaa ctattgataa aaatataggc aaaataggta atatgatttt tagatattgg
    12481 agtgattaaa tgagggcagg aataagaaaa gctttaatag ataatataaa agaattgaaa
    12541 ggttgttatg aacctaatgt accaaacaaa gatactaaaa agccttatat ggtagttgta
    12601 caagggcaag acaatgacaa tggagaaacg ataggttttg aaagaagtat agaagtatgg
    12661 atttatgaag gtagaactac atttaagaag ttagataaat taactaaaca agttattgaa
    12721 atcttagaca tgaatactat agttgatgaa tctgaaaatg aagcttttac ttgcatttat
    12781 aaaggtacaa gtgaaaatga tattgttgtt gaggaatggg atgctatagc aagaggtata
    12841 aggtttagtg taatagcttt agaagataaa gaagatacaa ctaatgatag gtgggtagaa
    12901 gctctatcta ggcacacaaa ggatttatta gaaatagaga gttataaaga taattggaag
    12961 aaaaacttta tagctccatg tgcattatgg cgaactacac atattgaaaa taaaagaatt
    13021 aactatcatt taattgagat tactaaaact atgaaatgtc atgttgtaag taaaaataaa
    13081 gatgaaatag ttaagcttct tgaaacatta gaaacaagct taataataga taaaagagta
    13141 agacttagag aagataagaa tatgtattta actcttgtta gcgtagttga ggatagggaa
    13201 tcagatatgt ttacaactgg acaattaaca gctgtgttta aaatgatagg aaagataaaa
    13261 agagaaggtc ctactatgga caaaatttat ggtaatggaa atttaagata ggaggtgtaa
    13321 gggttggctg aaacaaataa taaaaagatt aatgtgagta agcaggaaga aaaatattta
    13381 aaaagtgatt ttatagaaaa tagcgaagca cttggctaca agaaagaagt agttgcaggt
    13441 gctttattta attgtaagaa agaagaactt acaaagtcag agtttgagaa agcaataaaa
    13501 gagtttttag aaagagaggt gaagtaaaat ggcaactggt acatggaatg aaaaagaaaa
    13561 aaaggagata cctggttttt acaatcgctt taaaacacaa gcagaaaagt ctacaaacac
    13621 aggattaaag ggtagattag caatgcctat tagggctaat tggggagaag ttggcaaggt
    13681 tgtaacaata aaaaatgatt tgagacaact taaaactcta tttggtgatg atatgaatta
    13741 ttcagctttc aagctaggaa aactagcttt actaggtaat gtaaaggaat tacttttata
    13801 taggctcgta gatgggaacc aaaaaaaagg tacattaaca ctaaaagata ctacagagaa
    13861 tagtgcaaaa gatgtaatta agctagaaac taagtatcca actagcagaa attttaatgt
    13921 aacaataaaa tctaatctag tagatgcaga taaaaaagac tttatattct ttgaaggaac
    13981 taaacaatta tttagttcaa gtgtcaaagg gactatagat gaaatagtac tagaaataaa
    14041 ctcaaattta gataatgagt atgtaattgc aactaaagta gctgatagtg atacagcact
    14101 agcaaacttg gtaaatgtag cacttgaagg tggtaacgat ggttgcacat ctattactaa
    14161 tgagtcttat ctaaaagcac tagaagaatt tgaaagatat agttttgact cttttgtact
    14221 tgatggtgtg gctgaggaag cattgcagga aactacaaaa gcttgggtag ctaagaataa
    14281 ggagctagga aaagatatat tattatttct tggtggaaaa gcagaggata atataaaaca
    14341 aattaatgat aaatcaaaaa gttttaatga tgaaaatata gttaatgttg ggagttcagc
    14401 ttattatgag ggaataaaat atacacctag tgaagtagct gtttatattg ctgctctttc
    14461 tgtaagtaaa ggtataacag gaagtatatg taatgctaag actatatttg aagaagtaga
    14521 accaagatta agccaaagtg aagtaaaaga gtgtttgaaa tcaggtacac taatacttga
    14581 ttttgatgat ggagacgtaa ttatagttga tgatgtaaac acatttaaga agtatgtaga
    14641 tgataagaat gaagctatag gatatatctc taatattatg tttattaata ctataaataa
    14701 agatacttca ttgaagcgaa aggaatttgt aggtaagata tttaatgatt caacagggca
    14761 gacaactgtt atatgtgcat taaagaaata ttttgaagaa ttaatgggtc aaggcattat
    14821 atcagaattt aatgttgata tagatacaga gcttcaagca actgctaaag cagatgagtt
    14881 ttattggaaa tgggatgctg tcaaggttga tgtgatgaag aaaatctttg gaactggata
    14941 tttaggataa aggaggttat aaagtatggg aaaatatgat gaaaatatta tagatgctgc
    15001 aaatgttgca gatggctcga atgctaaaat aatagttgat gggaaagaag aaggatatgg
    15061 aacagagttt acagctgagg ttgaaaatga taagaaaacc tttagagtga ttggttgcaa
    15121 atgggagctt aacaaggcat ctactcaaaa aggtactttt tctttaactg tacttaaaac
    15181 aacatctgaa tggatcgaaa gaggatttga taaatttgaa ttaatatctg aaatagaaaa
    15241 tcctggatta gttggatatg aaagaattag atataaaaat tgtatggtag ataaaataca
    15301 actagcaagt ataaaagctg atgaaaatat agaaatacaa atagatggta cttttgaggg
    15361 ttatgagcta gtggataaaa tagcataata aataaattta agctacatgt aattaatttt
    15421 atatgtagct tttcaaataa aactataaaa atggaggaag ttaaaaatgg caaacttaga
    15481 taaagaattt ttaaatgaag gaatagaaga agaaagagaa cttactaaag aggaaatagc
    15541 aaagcaacaa gaagataata taattatgaa attgacagag gatgctatat tacctgaaaa
    15601 aactattttt gtaaaaagat tagatatacc acttacactt agggctttaa cagaaaaaga
    15661 gataagtgcg ttgcaaaaaa aatatacaaa agttactaag gtaagaggta gaagggaaag
    15721 caaactaatg gaagatgaat ttaatatagc tctaatagaa aaagctacaa tagttcctaa
    15781 tttttgcgat gcaagacttc ttaattctat gaatgtatct agtggtgttg aatttataag
    15841 aagaaagttc ttagcaggag aaatcgcatt aattagtgat gaggtactag aattgtctgg
    15901 attttatgaa gaattaagtg atgatgatat aaaaaactaa taaagagagg tgggaagatt
    15961 actattttat acaacgcata tgttaaacat agtattcttc cagaggactt tttaaaaaga
    16021 gagaaaacac ctcaacagct tcttagagtt tttactcaac atgaaataga acaagaaaat
    16081 aaagctatga aaaataaata aaatttaaac taaaagtgag gtgagagaaa tagctaaaaa
    16141 agaaatgtat cacattgatg ttgtcattga tgttacagga gatgaacaaa ctaaaaataa
    16201 attaagtgct atggaaagat acacgaaaca gacagaaaag agaatgagag cactaaatag
    16261 gataaaagct aatccagtta tacaagctca agataaaaca tctagtgttg taaatagaat
    16321 tagcaacaac ttaaaaagag tgggtagaac tatatctaca accataaacg caaaagatag
    16381 agcatctagc gttgtaaata gagttaaaaa caaagtaaat agcttactta caagtcgaca
    16441 aagagaagtt ttattaaagg ctagagacaa agctagtcaa gttgtagata aagtaaaagc
    16501 taaggtacaa aatttgactg cggctacaat aattagcttg aatatgaaag ctgacccagc
    16561 actaagagtt atttctcaaa ctagaagtaa gttaggagaa ctcaaaaaca acacaataat
    16621 aaatattaaa gcaaaaggtg aagaagcatt aaatactatt tctcgtacta agagtaaatt
    16681 acaagagttt tctaatagga cttatcaagc aattgtaaaa ttaaaagatg aagctagtcc
    16741 aactttgagt gggttagatg gtaagataag ttcttttata agtagtacta ttagtaagtt
    16801 tacacaatta gcagtaacag ccacagcatt aattggtggt gttggagtag gaagtgctat
    16861 aaaaggattt gcagactttg aacaagcaat gaaaaacgca caagctgtat caagtgcaaa
    16921 ttcaaaggaa atggcagaaa tgactgcaat ggcaagggaa atgggtcgta caactagctt
    16981 tacagctaaa gatgcaggga atgctatgta ttttatgggg atggctggat ggaaaagcaa
    17041 agaaatgatt gctggtctac ctggtatatt aaatttggca gcaacaggtc agacagattt
    17101 agcactaaca gcagatattg tgactgatgg tttaactgct ttagggctaa ctgcaaagga
    17161 tacaggaatg tttgttgatg ttatggcagc aacagttaca aactctaaca cagacataga
    17221 aagaatgggt gaaactttta agtatatggg aagtgttgga ggagcattag gtgtttctat
    17281 gaaagatttg agtttagcaa ctggcttaat ggctagtgca agcgttaaag gtagcatggc
    17341 aggtactgca cttagaggtg gtttagttag attaataaaa cccccagctg aggcacagaa
    17401 agctatgaat aaatatggaa tagaaataaa gaaaacaaaa gatggaaatt tagatttagc
    17461 tagtacaatc gttgacctta gagaaaaatt aggcggactt gaaggagtac aaaaaagtgc
    17521 tgcaataagt agcatatttg ggcgaacagc catggccggt tgggcggctg tagtaaacgc
    17581 aagtgaaaaa gattttaaaa aattaacaac agctataaat gaaagtgaag gagaagctaa
    17641 gagaattgct gatatgaaac tagataccct gtcaggacaa tttgaaattt taaaaagtgc
    17701 tattgatgat gtaagaatat cagtaggtca aagacttgga cctatgacac gaagttttgt
    17761 tgaacagtta acaaaagata tgcctaaaat aggggatgcc atcgttagtt ttgtaagtga
    17821 ttttataaat gattttgata aaattaaaag tattatgcaa aatgtcattt cagtaatatc
    17881 tggaatagta tctgcattta ttgctttcaa agctttaaag tttatttctt ttctaattcc
    17941 tatattaagc gatataggat ttgcaatagc tgcttttgca ggtggtgcgg caacgctagg
    18001 agaagcttta ttgtttgcac taggtggacc tgttggtgct gttatagcag gagtagtatt
    18061 actagcaaca gcatttacat tagcttatca aaaatcagat gcttttagaa aaattgtcaa
    18121 aaatgtagga aaatcaatta aaaatttttt acaagaagca ataatagcaa tttcaccttt
    18181 tgtaaatgtg tttggtaaca aattaaaaga attagggaaa gctgtaattc cattgttaaa
    18241 agtatttggg gattttgcat caacgctaat gagtaaaatc ggacctataa ttttgttttt
    18301 atcaagtaat gttttagctg gctttatatt aacttttgta gctgctgtag aagctgttaa
    18361 atctgctgta gtcgcgataa caggtgtatt gcaaggttta acatcaatta taaaaggagt
    18421 ttttgatatt gttggaggaa taataagtgg tgatgggaaa caaataataa atggcttaaa
    18481 atctgtattt gaaggaggaa taaaaattgt ttcttctgtt tggaaaggat tagtagatat
    18541 tgtaacttct cctattcaag ctgttgtaga tgttctagac gaaaaattcg gaaaaaaagt
    18601 agagggaata aagaaaaaat ggaatgaatt aaaagacttc ttaaaaaatc ctactaaagc
    18661 agctccaaaa gttcaacctg tcaatttatc tggagagaaa gcatcaaacg agttacaagc
    18721 ttcatcaaac ggagcaaaag catatataag ttcgttaggt caaaaaatag gtgaaggtat
    18781 tggaaaaatt aaagataaat ttggagaact caaaatatct gcaacagaag tatttaataa
    18841 tatagtatct ttcgtaggag gcaaagcaac cgaattaaaa gataaacttt tagaaggcat
    18901 aaaacctgct atagatacat ttaaacaatc attaagtaat ttaaaagaag tttttggaga
    18961 ttctttagat agcataaaag aagcttttgg aggtttaaaa actgtatttg atgaaaatat
    19021 taaaacgcct ttcgaaaatt taaaacaaaa agttttagaa acaaaagaaa gtttaaaacc
    19081 agtttttgat aacttaaaat ctagctttgc agaactagga aaagctcttg aaccaataaa
    19141 agaagcattt agtggaataa aagatttctt ttcaaatttg tttaagccaa ttaaagatga
    19201 tggagcaact aagacaacta aaaccaatat ggatgagtta aaacaatcaa cacaacgtgt
    19261 tggaacatct ttcaaagagt taggaaatgc tttcaaccaa ttaaaagaag cagcaaaacc
    19321 ttttatagac tatttaaaac agataaaaga ttctttaaca tctactctgg gagatatagg
    19381 gggaggatta ctcaaaggtg tagcaacttc tatagtttta gttataactt ctgttattaa
    19441 tgcaattgca tctattataa atgctgtagc aggtgctata aaaggtgtaa ttgatataat
    19501 aaaaggaata ttcgaaatca taggtgggat aattagtggt gatggtgaaa aaataaaaca
    19561 aggattttct gatgttttca aaggaattgg ggaagtagtc aaatcattgt gggaaggtat
    19621 aaaaggagtt ttaggagcac cacttaaagc agttgtaaat tttattgata atggattttc
    19681 agaaaaagta gggcaagtaa aacaatggtg gtctgattta aaaactaatg taggccaaaa
    19741 aataagcgga tttgttagtt ttgtaagcaa tggttttcaa caaaaagttc aacaagttgg
    19801 aatgtggtgg caaggactta aagtaaattt atctggcaaa ataagtggat ttgtaagtct
    19861 tgtagaaaac ggatttaaaa gtaaagtgga ttcaattaaa tcagcatggg atagtttaag
    19921 aaaaaaatta tcacaaaaaa taactggttt tgtaagtata gtaaaaactg gaataagtaa
    19981 tgtattggac cgttttgctg atggtggagt tgcaagtaaa ccaagtattt gtggagaagc
    20041 aggtcctgaa atggttattc ctctttctaa tagtaagaga agtagagcat taagtttata
    20101 tgaacaagca ggacagatgc ttggaactaa agcaagcaat aatgttattc caatatctca
    20161 aaaattagga actagtttta attctgcaag tagtatccaa aatagtaatt ctagtattat
    20221 taataatgtt agacaatttc ctaccaaaca agaagaattt aataatacag aaaatagaat
    20281 ttatcaagaa gctcaaccac aaaacataat ttctagtgga agtaatgcga ttaatgttgg
    20341 tggaatatct ataaatattc aaggtagcaa caacaaagaa gaaatgatac aagaaatatt
    20401 gtctcaagtg gaaagtggat taagagaagc attagaagac attggataat gtcgaattgt
    20461 tgttaaaaaa atcctcctta tagatgttat aatttaatta taaattacat gagggggatt
    20521 tgcatattat gtggggaaga tttaaaaata tgagtataat cttaaaggtt ttagttttag
    20581 tttgtgctat agcaattttt ccaataactt tattagcatt ttctatagaa tttgtagtta
    20641 aatcttttaa aagaaacgaa aggtttaaag ttgtttttgg cgtattttta gtttttatta
    20701 cattttcatt tgtatgtatt tggtatttgt tagaagataa tataacaact agcaatagta
    20761 gtaataaaaa acaagaagaa catctaaaag aagagccagg taaaaatcta gcaacaagag
    20821 aagcagaaga agaaacaaat aagaagaaag aacaagagaa acagaaaaat gaaggtacag
    20881 aagctgaaaa aaaagagcga gataaaactg agaaaaaaga aaaagtagat aaaaaatatc
    20941 aagagaagaa taaagagaaa gcagaaacga aaaagcaaac attaactagt gaagaattaa
    21001 agaaaaaagt tgattctata attccagcag agtataaagg aaattattac acaaatgatg
    21061 tattagatac agatggtagc tatgtactta gtttacaagt tcaaaatgca agttttgaca
    21121 atgaaagcag ttgtaaggca tttactaaag acttaattaa caagttgaaa gaatttagaa
    21181 tagactcagc agaagtatat tttgtaggtt caagtggtca aacaacatat caaattaata
    21241 tagatgattt cttgaaagtt caagataata ttaagagtgt agataatatg gagtttttct
    21301 ctttcaaaga ttttaaaaat tagatatata agaaaaagac gtttatttat taggaataga
    21361 tgtctttttt attgtaaaaa ggaagtgata atttggtaat agacatatac ctaaaaaatg
    21421 aaaaagaaaa aatagatttt cattttccag taaatccatt cgatagttta tctattaaaa
    21481 aagaaaaaag gtttgaaact gtagatatag taaacttagg cgaatttgac attaaaaaag
    21541 aaggagagaa gataagagaa atatcattta aaacatttct gcctaactta tatgacgctt
    21601 cttattgcag atacagtgag ttaaaaaatc caatcgaagt agtggcaatg cttgaaaagt
    21661 gggtagacca agctgaacca ttacgattaa tagtaactgg ttttggctac aatggattag
    21721 ttacaatatc taattttagt aatactcaaa cagcaggaag agaagaagac agagatattg
    21781 agataacatt tagaacttac agagaactga agatagagac attaaaaaaa gatacaaaaa
    21841 gtaatactaa aacagattta aaagataata gacctaatac ccaaactaaa tctaaaatat
    21901 atactgttaa agcaagtgat acattatata agatagctaa aaatctttta ggtaagggtt
    21961 caaggtggcc agagatttat aatatacccg aaaacaaaaa agtcattggt aaaaatccta
    22021 atataattaa aaaaggtcaa aagttggtga tacctagtaa atgaaaataa tattaaacgg
    22081 gaaatatgat attgcaaatt tcaatgaagg aataactctt tcagaagcta tagacggagt
    22141 tgcatataag atggatgtat cattagtaga acctaaacaa cttaaagata taaatattaa
    22201 aaaaggtgat aaaataattc taattgatat agcatatgag agtaaaaaag aagagacaat
    22261 atttgatgga gttgtatggg aaactagaag gagtgaaaag agtaagaaac taacattgtc
    22321 ttgcagagaa agaacagttt acatggaaga atcagaggaa caatatcagt ttaaagaaaa
    22381 tacagcaaca cagagaattg aatattactg taagcaatgg aatataccct attacaactt
    22441 agctaataca gggaagaaac ttgctaaagt aatacataag acaaatatac tagatatgat
    22501 aaaaaaggac ttaaaagaaa cagcaacaaa aggtggagac ttatttagag taaggatgga
    22561 taataaatta aaattattca agcttggtac taatgcaaat gtatataaat tagatagtat
    22621 attagaagat gctaacttta caagtagttt taatgatgca gtaacaagtg taaaagtttt
    22681 aggtaagagt aaagacgaaa atacaaaagc gcctataatt gggacatata aaaaagatgc
    22741 tgataagttt ggaacactac aaaagattaa acaagatgaa aagataaaaa atgctaaaga
    22801 agctaagaaa gcagcagaag caatgttcaa tagtggagag gaaacaataa gtgtagattg
    22861 tgcagtagat ataaatagaa taagagcagg tgacaaagta agtttaaaaa gtaaagaata
    22921 ttatgttata gatgtcactc atacactaga ttctagaccg aaaatgaagc tgaatatagg
    22981 gtctttagaa tatataagga ggaaatttta taataatgac tgatgctaga tttaatggaa
    23041 ttgctagaat attgaaagaa aatatgaata aaagtgtagc aaatggcact tttggaatgg
    23101 gttgtgaact tgcagaaata acagcaaatg gattaaaagt aaatggctat aaagatgaaa
    23161 tacaggacta tctagtatta gagaatttaa cattaaaaga agattatttt actttttcag
    23221 atgaagcttt aagtggagaa tatagacata agcataaaat agaaactcca aaggaattga
    23281 agccactacg tataggcgat aatgtgctag tagctgttat gggagctgaa tttgtagtaa
    23341 ttgggagggt tgtaaatgcc aaacctattt cctcaaagtg aaacttttga aactgtagaa
    23401 ttaaaaaata atgatgaaaa tgaattggac ctaaagggtt cttttttatt tgattttgaa
    23461 aaaggtgaat ttgttaaaaa cgcagatgga acactaaaaa aatgtgataa ggtgcaggcg
    23521 tacaaacaat ggtgtcaaaa ggctatatta acacctagat acaaaaaagc agcttataca
    23581 aacatttatg gaagtgaaat aaaagactta atagctagta acttatctca aagtgcaaaa
    23641 gagcttgaaa taactagatt aataaaagaa actattttgg ttcatccata tacaaaagaa
    23701 gttagtaatt ttatatttgt ttggcttgaa aatagtagac ttgttaatta tgaatttgat
    23761 gtgttaacaa tagatgatga aaatataacc atagatggaa acataaaaag gtaggtgatt
    23821 atatggaaag agagctacct ataccattat ttttaacaga agaggaggac tctgtacatg
    23881 aaaggatgtt aagtaacttt caagatgtga gcacactaga aggggacttt atttatgatg
    23941 caacaagacc tacagcagag cagatagctg aattaaaaca actaggatta caaaataatt
    24001 taaggattgc atttcctcaa actagctatg gagaatatct agaatggttg ggagaatgca
    24061 aaggagtatt taaaaatcaa ccaactaaat cggttggtat ggttacattt aatggtgctc
    24121 aaggaactat cattacaaaa ggaactattg ttacaactat agctacagat gaaaaacaga
    24181 gcatagaatt tgagcttctt gaaactaaaa ctataggagc aaatgaaaca gtagatatta
    24241 aagcagaatg taggattgca ggaactatag gaaatgtatc taataacact ataactgttt
    24301 tactaggttc tattagtggt gttaaatcag tttctaataa agaagatttc agaggtggaa
    24361 cagatataga agatgaagaa cattttagag aaagagttct tgtagcagag caagaggaca
    24421 aattaagtgg agctagttca gactatataa gatgggctaa agaagtagat ggagtgggat
    24481 atgcttatgt agttcccgaa tggaatggag cagggacagt aaaagtatta atactagata
    24541 aaaacagaaa agcagcaaca caagaattaa tagataaggt ccaagaatat atatatccat
    24601 tgaatatatc agaaggagaa aatagagatg ggaaagctcc tatcggtgca ttagttacag
    24661 ttgtgacacc tgacacatta cttattaatg taaaagctag ttttatattt agtaatggct
    24721 ttagtgaaga aactgtatta aacaatctaa aaactaagat agataaatat ttagataaga
    24781 ttgatttagg ggggacagtc tcatacaatg ctatacaggc gatagtaggc tctatgatgc
    24841 tgacagatga aggtatagaa gacttttcta atcttactat aaatgatgta aaagaaaata
    24901 taaaattgca agaccaagtg gtcggaatag gggaaatagt taacgaggtg gttggatgat
    24961 agcttctaaa aaaggtaaag aaatgcttct tacattatct cctatctatg aacaatctat
    25021 cataatgcaa agcttatatg aagctatagg aagcgaattt gataatctag aattattaaa
    25081 taaagaaata gagttacaat tattccctca gagtgcgaca tggggacttg aattttggga
    25141 aaatagagtg ggtttatcca ctaatataga tgaagatata gaagctagaa gaagaaaggt
    25201 cattgctaag cttcaaagta aatatattat gacacctaaa agaatggcta tgatactcca
    25261 atcttataca ggtgcaaaca taaaaataaa tgaaaatata tctccatata cttttggtgt
    25321 tgaattaacc agtacccaag gttttcctaa agatttagaa gatttatata agagagtaaa
    25381 tgttataaaa ccttctcatt tagctgtaag ttataagtta gtttctttat tgaaaagtaa
    25441 aacctatttt gcacaaacgg caattatgag cgaagaaata actgtatatc cgtacacaag
    25501 caaagaagta aaagcaagtg ttaaagccaa gtttgcacta gctcataaca tgagctcaga
    25561 aacattaaca gtatatccaa gataggaggt ggcataaatg gctgatgaac aattttacac
    25621 aatactaaca aacataggta aagctaagat tgctaatgca ggaatgttag gtaagtcagt
    25681 aattttagag aagattcaag caggtgatgg tggaggaaac tactataatc caacagaaga
    25741 ccaaacagca ttaaaaaata aagtttggga agggaatata aatgcttttg ataatgatga
    25801 aaataatcct aactggatta ttgcaacagc atgtatccct ggttcgatag gtggatttac
    25861 agttagagaa atgggtctta tagataatga aggagatatg attgcagttt gtaaaagccc
    25921 tgaaacctac aagccaaaag ttgataatgg agctatgaaa gatttgtatt tgaaatttat
    25981 catagaagta tctaatgtag agaaagtgac attagttgtt gaccctacag ctatttttct
    26041 aactaaaaaa gatgaagaaa aaatattaac aaatattaat aaactagaca ctaaaataga
    26101 tacaaccaaa acagaattaa caagcaacat agaaactact aaaacagagc taaacactag
    26161 aattgacaca gaaaatgaga aacaaaatat taaaattgac caattaatcg caggtggttc
    26221 aaatgtggca tctactcaaa taataacaat tga
//
LOCUS       DAEPID010000051        26086 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.051, whole genome shotgun sequence.
ACCESSION   DAEPID010000051 DAEPID010000000
VERSION     DAEPID010000051.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 26086)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 26086)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..26086
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.051"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            229..771
                     /locus_tag="KR257_002462"
     CDS             229..771
                     /locus_tag="KR257_002462"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424618.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="N-acetylmuramoyl-L-alanine amidase"
                     /protein_id="HBH0031145.1"
                     /translation="MKICITVGHSILKGGKSTGVNGIVDEYNYNKKLAPMLAEMLISQ
                     GNTVDVIICPERHFMSEREEFFYRVPKVNSGKYDLLVELHLNKADGTQCGTEVLYYGT
                     EGLEYAKRVSNRLGELFENRGAKKRENLYILRNTNPVAIQIESFFCDNVNDCNKANES
                     GYDYIARLITEGILNKDINM"
     gene            1099..2592
                     /locus_tag="KR257_002463"
     CDS             1099..2592
                     /locus_tag="KR257_002463"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003433912.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DEAD/DEAH box helicase"
                     /protein_id="HBH0031146.1"
                     /translation="MKYTFEKFKLNEKILKSLKSLGYNIPSRVQREVIPKLLKGQNLV
                     VRSKTGSGKTASFAIPLCENINVDYNNIQALIVVPTRELALQVKDEISDIGRLKKVRC
                     SAIFGKQSIKDQIAELKQRVHIVVATPGRILDHINRGSIKLENVKYLVIDEADKMFNK
                     GFVEQMEKILLNLPKEKIVSLFSATIDEEIKYICEKYMLDYSVINIEENESDTNQKTR
                     QIDDKIIKANGREKYILLKELIYSENPKSVIIFCNTKEKVSKLYNKMSKEGFLIRELH
                     ADLSQERRIFVIKDFKNQKFNVLVSSDVASRGIHIDDISLVINYDVPQDKENYIHRIG
                     RTGRKGNSGKAITIVTEKDEKYIENIETYIGYKINELKDIEKSRITHGKILFEEYSKG
                     ILKKVSKRKKVDKNSYNSKDIKLNIESEVVKLYLNAGKKKKIRVLDIVGAFSNIKGIT
                     NDDIGVIEVQDLCSYVDILNYKGDLILKKYKEIPIKKKMVKVKRDIR"
     gene            2666..2899
                     /locus_tag="KR257_002464"
     CDS             2666..2899
                     /locus_tag="KR257_002464"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903070.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0031147.1"
                     /translation="MKAEDMKRKVSPIDLERILVTGGVIKHEDSIWLLDFWGNKDIAG
                     ILLMPPTRHVILHLNDCCKWKEYFRTKKKFYRS"
     gene            3055..3819
                     /locus_tag="KR257_002465"
     CDS             3055..3819
                     /locus_tag="KR257_002465"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729104.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha/beta hydrolase"
                     /protein_id="HBH0031148.1"
                     /translation="MAYFNYNDKQCYYNEIGDGTPLLFLHGNTASSKMFNDIIDFYKD
                     EYKVILIDFVGHGKSQMVDKFSADLWFDEAMQVICFLEAMNYKKVNIIGSSGGALVAL
                     NVALERPDLVNKVIADSFEGEVPLESFVQNVKIEREASKQDDGAKAFYIYNQGENWEK
                     VVDNDTEAIFEHYKTIGKFFHKPLETMQPEVLLTGSREDEFVSLISSDFFENTFSLLL
                     EKIKNGKMYLFDKGGHPAILSNGLDFSNVAKKFLEE"
     gene            complement(4104..7283)
                     /locus_tag="KR257_002466"
     CDS             complement(4104..7283)
                     /locus_tag="KR257_002466"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003433922.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DEAD/DEAH box helicase"
                     /protein_id="HBH0031149.1"
                     /translation="MKIDMIYKLIRRNTEPSRWSRGVKYYTNQLVDYIDIDIDDLQNN
                     LLTFRGGVNSEDNYSFYFNSITIDIKHFKIIENDCSCADCQSKGKSIFICKHIVAIVI
                     KSLKQIKNKKDVPPILIDILGADKDKLSNTNSKTSLDLSKQLLSLLDNTKRERVNLDV
                     LINVDSNKAIAEFKIGIDKMYILKNITEFAYSKLNGYELDFGKKFTYNPNTHYFADED
                     EKLVDIIEEYGTNLSYNFSSSHSKKFMEINASSLKQFLNAIKYKDFTLIFSKEEYHPK
                     ILNDTLPVRFDFKNIEDKIVLYSKDSLPVPLTKKNDVLLYDGNIYLLSHKKAHDYSKI
                     YQILSKTKELKFDKEDSKDVLGLLVPRLKSISQEVHLDDNIKNNITKDFKSEFYFDMI
                     DGNICCDVKYIYDDEDKKFVLPNIQKEATIENKLTSSQFTKENNHYVFKGTDHDLFTF
                     LDLQLESLKEFGDIYYSEKFKLKKIYNASSIQASINQTNQNYLEFNFNISDINPREYK
                     DILKAFQEKRTFYKLKDGNFIDLSERETKDFFELVENLDIMDKSKNNKIHKNKALYIN
                     DVIRSKNLKFIDGKKELDSICEKFRNFDSINLEIPANLNANLRDYQINGLNWFKVLDY
                     YKFGGILADEMGLGKTIQTIAFLLSLSNKKSLIVTPTSLIYNWKNEFEKFAPDIKVLL
                     IHGNKRDREKCFMELENFDVILTTYGTLRNDLEKYSEIKFDYCILDEAQNIKNPVALV
                     TESVKSINAENKFALTGTPMENNLLELWSIFDFIMPGYLYSKAKFQELFINKEDNVKN
                     LKKLIKPFILRRSKKQVMKELPDKIEKNFFVELNKEQKKIYSVYSKDIQDKMKDKNLK
                     KDKIVIFSYLTKLRQLCLDPSIVVKDYNKKSSKIETCLEILRDSINENHKILLFSQFT
                     SVLKNISKELDKYKIKYHYIDGKTNAKERLELVDEFNNSMDKKVFLISLKAGGTGLNL
                     TSADMVIHFDPWWNPSVENQASDRAHRFGQKNSVQVIKLIAKGTIEEKIIKLQESKKE
                     LINQFINGELSNEGVLKSLSDEEIINLFN"
     gene            7564..9741
                     /locus_tag="KR257_002467"
     CDS             7564..9741
                     /locus_tag="KR257_002467"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003433925.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="molybdopterin-dependent oxidoreductase"
                     /protein_id="HBH0031150.1"
                     /translation="MYNKYNNLYLLLGKENVNMDSYRQLKAKIPCKETGIEIKRTLCD
                     ICSPGVHCGIDAYVKDGKVIKIEGTKEHPMNKGLLCTKGLCNREYIYREDRIKTPLKR
                     IGKRGEGKFKPISWDEAYREIAEKLNRVKSEYGAKHVAFFTGYGKWYRPFLQRFASSF
                     GSPNYGTESSSCSTSAQMAGNVATGRNFTMQDMENAKTYLGWGFNPYYSKFLNSVNLI
                     KLKEKGLKFIIVDPRITPTTQKLADLHLRIKPGTDGALALGMANLFIQKDLIDREYIE
                     KHVHGFNEYKEYVKLFDLDTVSRITGVSKDNIVKAVEMLSQGPFCINESAAPIVHHQN
                     GFQNYRAMMSLSAITGNYDRIGGNIPKQDYFAGKIGGFQTLEKEFVKEVLPKNINERI
                     GGERFPLWNEMVTQFQAMDLPRQIEEKTPYEIRALFCHGINARMFTNSGRLFKALNSV
                     DFFVNIDLFMTDTSKYADILLPACTSFEREECKSYPGGYITYTKKVIDKLYDSKSDVE
                     ILSDLANAMNIDDDLLKAGYEASIRHMFKNTCVDVDKLKESDLPLKCKDFKPYIVGSY
                     TREGYDTSTSRFELKSTIIEKYKDFGLDALPTYRGFNDNIDDEYTHLLTSGARISNAL
                     HSRLHDIKLSRILKNEASCDISSLDAKELGVISGDYIKITTKIGSLDVKVNVTDRVLY
                     KNIHMYHGYREADINSIICDNFDPYSGFPAYRSCKCKIEKMNR"
     gene            9755..10177
                     /locus_tag="KR257_002468"
     CDS             9755..10177
                     /locus_tag="KR257_002468"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003433927.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="4Fe-4S binding protein"
                     /protein_id="HBH0031151.1"
                     /translation="MKSLFKFNKELCTACGACLLACIDQNDNNIDNGELFRHVFTIEE
                     GENIEYFSLACIHCNEPKCLGVCPKNCFKKEEGFIVLDNQNCIGCKLCEKACEYGALI
                     YGNDGKANKCNGCIERYKCGMDSPCVMVCPTGALKFNK"
     gene            10585..11388
                     /locus_tag="KR257_002469"
     CDS             10585..11388
                     /locus_tag="KR257_002469"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897329.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transporter substrate-binding domain-containing
                     protein"
                     /protein_id="HBH0031152.1"
                     /translation="MKKLKLIIMFALVSALLVTGCSSGNNKNKEEQKVIRVATSGTYY
                     PFAFKDKDKLKGFEVDFWDEFAKRTNCKVEWVLTDFSGLFGLLEADKADVVSAQLTAT
                     PEREKKYAFSDAYNYSGTNIIVREDDTSIKSIDDLVGKKVGVGTGAVANEILKEKYPN
                     DEIKIVNYSSATLKGNYQDLEMGRLDAVVAQDVEALIAIKEQKLNLKMIEPPIQFGAC
                     SFALQKNEKGEKWTKEINEVIEEMYKDGTLTKISENWLGKDITKEPINE"
     gene            11381..12049
                     /locus_tag="KR257_002470"
     CDS             11381..12049
                     /locus_tag="KR257_002470"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890353.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amino acid ABC transporter permease"
                     /protein_id="HBH0031153.1"
                     /translation="MSNFNFEFCLSIFPFLIKALGITILISIVAFFLSILLGVILAFF
                     TQTKSKVLQYITRVYVSFFRGTPLLIQIFFFYFGFPMIFSFMKDCSPYLAIVICLGVN
                     SSAYMAEIIRASIESVDKGQQEACYAFGLSKYQSMVKIILPQAATSAVPPIVSCTLDI
                     IKGSSLGLTIGIQDLMGVAQVEAASSFKYFEIYMITILIYWAVSIILSNIQSKVEKRI
                     RRAY"
     gene            12285..12947
                     /locus_tag="KR257_002471"
     CDS             12285..12947
                     /locus_tag="KR257_002471"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003433934.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amino acid ABC transporter permease"
                     /protein_id="HBH0031154.1"
                     /translation="MAFNMKYFLELFPTIMKSFNVTVILAISSLVFSLIIGTIVALSS
                     YYKVKVLNQICKVYVSIFRGTPLMPQLFFLYFGLAYMSDFVKNMDPVFATSIVLSLNM
                     GAYMSETIRASILSIDTGQIEAAYAMGLTNLQTMKRIVIPQAVRVALPSLFNNFIDLI
                     KGSSVAFVVGVNDIMGAAKSQGALSFKFFEVYGAVMVIYWCIITPLGWGQKKLEKKIS
                     NY"
     gene            13007..13804
                     /locus_tag="KR257_002472"
     CDS             13007..13804
                     /locus_tag="KR257_002472"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003433936.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amino acid ABC transporter substrate-binding
                     protein"
                     /protein_id="HBH0031155.1"
                     /translation="MIKRNIIKCLVAVLSLTFVITGCSKKEEVKNEKVITVASSNSAD
                     PYSYVDNGEHKGFEVDMWKEIGKRSGYKIKMEPTGFSSIFGMLDSGKVDVAANFFGMS
                     KERLEKYDASIPYGSDSVCIAVKDGNNEINKLEDLKGKVVAVSEGSQGQQVATSVNKD
                     NLFQEKVYGDGTSGLQDLDLGRVSAWIDAELTIVGDAKKANMKVRVLDKKLSATNIAY
                     FFKKNDDKSKTIKEDVNKAIEEMLADGTVKKISEKWFGMDVSADIQK"
     gene            13922..15112
                     /locus_tag="KR257_002473"
     CDS             13922..15112
                     /locus_tag="KR257_002473"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003433937.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amidohydrolase"
                     /protein_id="HBH0031156.1"
                     /translation="MEVLQMIETKIKSIALKNREKIIKIRRQIHSNPELAFKEYKTSK
                     LIKEELNKLNIEYINIAGTGVLATIKGKNNGGKTILLRADMDALPIKEENDLEFKSIN
                     DNMHACGHDAHVSWLLGTAMILNDIKEELNGNVKLLFQPGEEKGGSDIVIKENVLEGV
                     DALATGHCWPTIESGKIGIARNCAMAATNTFEITIIGKGGHGAEPHNCIDPIAVGNAV
                     YSSIQQIVSRKIDPVVPVVVSVCSFNSGVSKNIIPDVCTLQGTIRAISKEQVIEVSKI
                     LEYIVKNVCKAHGADCKFEKSTGGDAVINDKNMIEIGRESACKILGAENVEIIDFPAM
                     TGEDFAIYMKEKPGLFMYIGVGDKEKNINYRLHSNKFNIDEKCLSIAPSLFSQLTVDY
                     LCQL"
     gene            15221..15970
                     /locus_tag="KR257_002474"
     CDS             15221..15970
                     /locus_tag="KR257_002474"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890348.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amino acid ABC transporter ATP-binding protein"
                     /protein_id="HBH0031157.1"
                     /translation="MIKVENLHKSFKGTEVLKGINLEISQSEVVAILGSSGTGKSTLL
                     RCLNYLVEPTKGKIMIGDVKVDVEKATKKDITNLRKHTSMVFQNYNLFKNKTALENVM
                     EALIVVHKKSKKEAREISLKLIDKVGMLDRKDFYPSKLSGGQQQRIGIARAMAVNPNV
                     ILFDEPTSALDPELVGEVLSVIKSLAKEGITMLIVTHEINFAKEVADKIIFMDNGVIA
                     EEGTPDEIFNNPKNERTAKFLNIIRKEEVFS"
     gene            16561..17622
                     /locus_tag="KR257_002475"
     CDS             16561..17622
                     /locus_tag="KR257_002475"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003433941.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dicarboxylate/amino acid:cation symporter"
                     /protein_id="HBH0031158.1"
                     /translation="MRDFLKNYKSSIILLACTIVGAIVGLVLGPKASILKPFGDLFIN
                     ALLMIVVPLVFLSVSSGVASIKNMERFGKIMKGTAIVFMGTTLVIAFLGITSALLFNP
                     SKGLDVSSVKNLMVTQDAETLESKGTLLDQVVSSITVKNFGDLFSSSNLLQLVIFAVL
                     IGTAIAMMGDRGNTIRKLLSEGTEAILKVVSIFMLYAPIGLGCYTATIIGELGSKIIQ
                     GYVRVFVIYSLTAAMYFLLFYSLYAFLSAGKQGFRQFWRNAIKPIATALATSSSSACI
                     PSNLEASKNIGVPDDISETVIPLGINIHKDGSVLAVIIKVAFLSGILGSGMANPATIG
                     QLFITVFVVGVFMAPVAGG"
     gene            17635..17832
                     /locus_tag="KR257_002476"
     CDS             17635..17832
                     /locus_tag="KR257_002476"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424591.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cation:dicarboxylase symporter family
                     transporter"
                     /protein_id="HBH0031159.1"
                     /translation="MLVVSIFGFPVEAIPLLTVITTITDIPNTILNTTGNTVSSMLVS
                     RLVEGKDWLIDKTAITTKKIS"
     gene            complement(17996..18700)
                     /locus_tag="KR257_002477"
     CDS             complement(17996..18700)
                     /locus_tag="KR257_002477"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424589.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Crp/Fnr family transcriptional regulator"
                     /protein_id="HBH0031160.1"
                     /translation="MQQGSDYLKKFLEKHIDLLKKIPLFEGIKSDELEEMLECLGVVD
                     KTYTKDSIIFSVGSEVTSIGIMLKGSAHIIKEDIEGNRNIVAELLPGDLFGEVFACTR
                     LHKSNVTVTTTSSCEVLFIKFKSVTGICSSACVFHNRLVENMLQLIAEKNILLHNKIE
                     LLSRKTTREKLLMYFSKQIEQTGSHQFTIPFSRNEMADFLCVDRSSMSRELGKMRDEG
                     LLSFNKNKFEIFYFKK"
     gene            18865..19590
                     /locus_tag="KR257_002478"
     CDS             18865..19590
                     /locus_tag="KR257_002478"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424588.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="4Fe-4S binding protein"
                     /protein_id="HBH0031161.1"
                     /translation="MMRKIIKIDEEKCNGCGLCVEACHEEAIGMVNGKAKLLRDDYCD
                     GLGDCLPTCPTNAISFEYREAAEYDEAAVKANMEAKKAQKKTLACGCPGSQSKSINRE
                     VSNSMSISNDIVEIKGSQLNQWPVQIKLVPTNASYLKNASLLIAADCTAYAYGNFHNK
                     FMKNKVTLIGCPKLDEVDYAEKLTEILKENDIKNIVVTRMEVPCCGGIVNAVKTALQN
                     SGKMIPWQIVTISVDGKIVDGEI"
     gene            19650..21242
                     /gene="hcp"
                     /locus_tag="KR257_002479"
                     /gene_synonym="priS"
     CDS             19650..21242
                     /gene="hcp"
                     /locus_tag="KR257_002479"
                     /gene_synonym="priS"
                     /EC_number="1.7.99.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430549.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hydroxylamine reductase"
                     /protein_id="HBH0031162.1"
                     /translation="MEKMFCFQCEQTAGGKGCTINGVCGKKGGTANLQDELTGVLIGL
                     SRATIGNKNRPTSETDKIMIEGLFTTITNVSFDDEAIKRQIEKTEVEKSKLVPRCSDC
                     STTCNRNDNYDMKDLWNDNEDIRSLKSLILFGLRGMAAYAYHAMVLGYTDKDVNEFFY
                     EGLIAVGGDLSIDELLGLVMKTGEINLKCMELLDRANTETYGTPEPTQVSMKIEKGPF
                     IVVTGHDLYDLHKLLEQTKDKGINIYTHGELLPAHAYPKLKEYKHLKGNFGTAWQNQQ
                     KEFDNIPAPILFTTNCLMPVKDSYRDRVFTTEVVAYPGMVHIDEDKDFSSVIEKALEL
                     GGYREDVHMTGINGGDTLTTGFARGTVSSVQDKVVDAVKSGAIRHFLLVGGCDGAKPG
                     RNYYTEFVKQAPKDTVILTLACGKYRFNDLDLGDICGLPRLMDMGQCNDAYSAIKVAV
                     SLANAFECGVNDLPLSMVLSWYEQKAVCILLTLLHLGIKNIYIGPSLPAFLSKNVLDI
                     LVDKFALTPISTPEEDMKKILG"
     gene            21614..22519
                     /locus_tag="KR257_002480"
     CDS             21614..22519
                     /locus_tag="KR257_002480"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890334.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="patatin-like phospholipase family protein"
                     /protein_id="HBH0031163.1"
                     /translation="MKNSNFNILAFDGGGLKGALSISILERIVKEYPNLLNNINMFGG
                     TSTGSLIALGLAYGVSPKEIKELYSIENSKYIFNKSYAEILRPKYENKNLKEVLLSIF
                     PEELELKDLNKLVMIPSFYIGNEENAWKPVFYNNMPNSFTKTSKVVDVAMASSAAPVF
                     FPTYNRHVDGGIIATDPSLACIIHAIDSGFKLKNTRLFSIGTGYVYNSIKADTTEWGA
                     IDWIINKEPDLPIISITLEGNSQMSQLFSQKLLGDNYYRLNPKMEKDVAMDDCDALEY
                     LMSLGENCDIKDAFGWIKKKSFYRN"
     gene            22643..23596
                     /gene="msrA"
                     /locus_tag="KR257_002481"
     CDS             22643..23596
                     /gene="msrA"
                     /locus_tag="KR257_002481"
                     /EC_number="1.8.4.11"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893500.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptide-methionine (S)-S-oxide reductase MsrA"
                     /protein_id="HBH0031164.1"
                     /translation="MIKLATFAGGCFWCMVKPFDKYDGVIKVVSGYTGGHVENPTYQE
                     VCSGTTGHLEAIQITYDDDIISYDELLNIFWKQINPTDDGGQFGDRGTQYKTAIFYHD
                     EEQKNIALESREHLENSKIFDSKIVTDIIPATKFYEAEENHQDYYKKRPLNYNMYYKG
                     SGRYNFVKSHWDGNNINREELKKTLTHIQFEVTQNDMTEVPFENEYYDNNKEGIYVDI
                     VSGEVLFSSKDKFDSGCGWPSFSKPVIDKSIIERSDFSQGMYRVEVRSAKGNSHLGHV
                     FDDGPKELGGLRYCINSASLKFIPRENMEALGYGEYLKLFE"
     gene            23749..24879
                     /locus_tag="KR257_002482"
     CDS             23749..24879
                     /locus_tag="KR257_002482"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729111.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="HBH0031165.1"
                     /translation="MNLKDFNGKRLKSARIFRAKTIEQLSKETKINKKDLKAFEENKY
                     VPNIENTLKLSNILNFPKEYFYKNENINIVVEDSHFNPQSKLPRVEEISYREKIIIIH
                     KIYSFMENYIKFPKENLPNRKVMSDININDIESLAYKTREFWDLNSTPIVNMVSLLES
                     KGIIISGMNVDRKGATIFTQKQRISKESKYLISLGNDKKSASIRNYTLACELGYIISS
                     ELRIPSKQFSEDEYACAFLLPKESFLKDLTHPEDLDYYVELKKKWIVPISAMIFRAYN
                     LEKINYKKYNYLMNEMDKKGWLIEEPLDKMKGSSPTYLKRAVELLIENKIMSVNSIVS
                     SLEEFGINLYPEDLELLMGLKKGLLSQEVNKKSKVIKFDGKK"
     gene            complement(24996..25964)
                     /locus_tag="KR257_002483"
     CDS             complement(24996..25964)
                     /locus_tag="KR257_002483"
                     /EC_number="1.1.1.27"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861477.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="L-lactate dehydrogenase"
                     /protein_id="HBH0031166.1"
                     /translation="MAIKPRKISIVGSGHVGSHCGFSLITQGVCDELFMIDIDESKSK
                     AQALDLADAVSYLPHKVHIEKGTFSDCKDSDIVVISVADSSEGPLRRQNTTRLDLLRP
                     TIGMIKSIVKPIVDSGFDGIFVVISNPVDVVTNYIWEKSGFPKNKVIGTGTALDSTRL
                     RRILSEETGIAQQSIQAYSMGEHGDSQMVPWSHVSIGGKPILDMIKDNPSTYSNLDLP
                     SIVEKNKKTGISIINGKDCTEFGIGTALVEIVKAILHNEKKVLPVSTLLEGQYNERNV
                     FAGVPCVIGKDGIEEIIEINMTEYEQNEFNKSCSVLREYIALSKTL"
BASE COUNT        10087 a         2844 c         4332 g         8823 t
ORIGIN      
        1 tgatatattt atcatatata taaatgatta attaaacaat tataaataat aagtatatta
       61 taatatttaa aaaatataga tttatgataa aataagacaa atatgttaaa aaaatgataa
      121 tcacggagaa cttttacctt cttcaattaa tatattatta ttagtaataa ctttaaaatt
      181 atattactat tatataaaaa ttggcttaaa agaaggtgaa aaaagtaaat gaaaatatgc
      241 ataacagtag gtcatagtat actaaaaggt ggtaaaagta caggtgtaaa tggtatagtt
      301 gatgaataca attataataa aaaattagct cctatgttag ctgagatgct tataagtcaa
      361 ggtaatacag tagatgtaat aatttgtcca gaaaggcact ttatgtcaga aagagaagaa
      421 tttttctata gagttccaaa agtaaacagt ggtaaatacg atttattagt agagctacat
      481 ttaaataaag ctgatggaac acaatgtggt acagaagtgc tttactatgg cactgaagga
      541 ttagaatatg ctaaaagagt atctaataga cttggagaat tatttgaaaa tagaggagct
      601 aaaaaaagag aaaatttata tatattgaga aatacaaatc cagttgcaat acagattgaa
      661 agttttttct gtgataatgt gaatgattgt aacaaagcaa atgaatcagg ttatgattat
      721 atagcacgat tgattacaga aggtatattg aataaagata taaatatgtg agattatggt
      781 gatttaggta ttgattaata ccttttaata ttagatataa ataaaaatac aatgtattag
      841 tataatttaa actttcaaaa gatagattag tttgattatt gacaagagat acctccttga
      901 aaatattgat ttatcagtat atttaaggag gtatttaaat ataaaaattt aattaatttg
      961 ctactaaact ataggtttat agagtatata tttttatctt cagtctaata aataatataa
     1021 aaatagtaga accttgtatt ataataatat aatgtagaaa aatatataga taagataaat
     1081 ataataaggt ggtaatatat gaaatataca tttgaaaaat ttaagttaaa tgaaaagata
     1141 cttaagtcat tgaagagttt aggatataat ataccttcta gagtacaaag agaagttatt
     1201 ccaaaattat taaaaggtca aaacttagta gttaggtcaa aaacaggaag tggaaagaca
     1261 gcaagttttg caataccttt atgcgagaat ataaatgtag attacaataa tattcaagct
     1321 cttatagtgg ttccaacaag agaattagcc ttgcaagtaa aagatgagat atcagatata
     1381 gggagactaa agaaggtgag atgtagtgct atatttggta aacaatctat aaaagaccaa
     1441 atagctgaat tgaaacaaag ggttcatatt gttgtagcta ctccaggcag aatacttgac
     1501 catataaata gaggttctat taagttggaa aatgtaaagt atttagtaat agatgaggca
     1561 gataaaatgt ttaataaagg ttttgttgaa caaatggaaa aaatattatt aaatttacct
     1621 aaggagaaaa tagtaagtct tttttcagct acaatagatg aagagataaa atatatatgt
     1681 gaaaaatata tgctagatta cagtgttata aatatagaag aaaatgagag cgatactaat
     1741 caaaaaacaa gacaaataga tgacaaaata atcaaggcaa atggaagaga gaagtacatc
     1801 cttttaaaag aattaatata cagcgaaaat ccaaagagtg tgataatatt ttgtaatacc
     1861 aaagagaaag tatctaaatt atataacaag atgagtaaag aaggtttttt aataagagag
     1921 ttacatgcag atttatcaca agaaagaaga atttttgtaa ttaaggattt taaaaaccaa
     1981 aaatttaatg tattagttag tagtgatgta gcgtccagag gaatacatat tgatgatatt
     2041 tctttagtaa taaattatga tgtgccacaa gataaagaaa actatataca tagaataggt
     2101 agaactggga gaaaaggaaa tagtggaaag gcaattacta tagtaactga aaaggatgaa
     2161 aaatatatag agaatataga aacgtatata ggatataaaa taaatgaatt aaaagatata
     2221 gaaaaaagta gaattacaca tggcaaaatt ttgtttgaag aatattcaaa aggaatccta
     2281 aaaaaagtat caaagagaaa aaaagttgat aaaaattctt acaatagtaa agatataaaa
     2341 ctaaatatag aaagtgaagt tgttaaatta tatttaaatg ctggtaagaa gaagaaaata
     2401 agagttttag atatagttgg tgcatttagt aatataaaag gtataactaa tgatgatata
     2461 ggtgtaattg aagttcaaga tttatgttca tatgtagata tattaaatta taagggagat
     2521 ttgatattaa aaaaatataa ggagatacct ataaagaaaa aaatggttaa agtgaaaaga
     2581 gatatacgat aatttagtca atattgatga attgctttgt tatcgaaatg aagttgcaaa
     2641 aaacacaata gaagttgtta aggatttgaa agctgaagat atgaaacgaa aggtctctcc
     2701 aattgactta gaaaggattt tggtgactgg aggagtaata aagcatgaag attctatttg
     2761 gttgttggac ttttggggga ataaagatat tgctggaatt ttgcttatgc ctcctactcg
     2821 tcatgttata cttcatttga atgattgttg taaatggaag gaatattttc gtacaaaaaa
     2881 gaaattttac agaagttaaa ttataataaa ttagacaaac aatagataaa ttagcaagga
     2941 atgttgattt tatctacatt ctaagttata ctatttttaa gtggctaatg gaatagtcat
     3001 tttaaatata agtaataaat atatacctat agggatatta aaggggggaa atatatggca
     3061 tattttaact ataacgacaa acagtgctac tataatgaaa ttggggatgg tacaccatta
     3121 ctttttttac atggaaatac agcctcttcc aagatgttta atgatataat cgatttttat
     3181 aaagatgaat ataaagtaat attaattgat tttgtaggtc atggaaaatc tcaaatggtc
     3241 gataaatttt ctgctgactt atggtttgat gaggctatgc aagtgatatg ttttttagaa
     3301 gcaatgaact ataaaaaagt aaacataatt ggtagtagtg gaggagctct tgttgcatta
     3361 aatgttgcac ttgagagacc tgatttagtg aataaggtaa ttgcagatag ttttgaagga
     3421 gaagttcctc tagagtcatt tgtacaaaat gtgaaaatag agcgtgaagc atctaagcaa
     3481 gatgatggtg caaaagcttt ttatatttat aatcaaggag aaaactggga aaaagttgta
     3541 gataatgata cagaagctat ttttgaacat tataaaacta taggaaaatt ttttcataag
     3601 cctctagaaa ctatgcaacc agaggtgctt ttaacaggaa gtagagaaga tgagtttgta
     3661 tctctaatat ctagtgattt ttttgaaaat actttttcat tacttcttga aaagattaaa
     3721 aatggtaaaa tgtatttgtt tgataaaggt ggtcatcctg caattttatc gaatggatta
     3781 gatttttcaa atgtagcaaa gaaattttta gaggaataat ttaaccaaaa tttataataa
     3841 tgaaaactgt aaaatggatt gcaaaactta caaaagtgag tgtacatata cttcattatt
     3901 atgatgaaat agtattgtta aaacaaaata ttctaatagt caagttatta catttgtata
     3961 tgcaatatgt atagaaagag atatcattag attgtaaagt tgggattaaa taacaatatt
     4021 aaattttatt tattcagata ttttagctta actatataaa tgttagaaca aatttatata
     4081 gttaagctgt aggattaaat aatttagtta aataagttta ttatctcctc atcagataga
     4141 ctttttaata caccttcatt agaaagttct ccatttataa attgatttat aagctctttt
     4201 ttactttctt gtaattttat tattttttct tctatagtcc ctttagcaat caattttata
     4261 acttgtactg aatttttttg accaaatcta tgagctctat cactagcttg attttctact
     4321 gatggattcc accatgggtc aaagtgaatt accatgtcag cagatgtaag atttaaacca
     4381 gttccgcctg cttttaaaga tattaaaaaa acttttttat ccatactatt attgaactca
     4441 tctacaagtt caagtctttc tttggcatta gttttaccat ctatataatg gtatttaatt
     4501 ttatacttat caagttcctt acttatgttc ttaagcacag aagtaaattg tgaaaacaat
     4561 aatattttgt ggttttcgtt tatactatcc ctaagtattt ctaaacatgt ttcaattttt
     4621 gaactttttt tattgtaatc ttttactact atacttgggt ctaaacaaag ttgtcttagt
     4681 ttagttaaat aagaaaatat aactatttta tctttcttta gatttttatc tttcatttta
     4741 tcttgtatat cttttgaata tacactatat atctttttct gctctttatt caattcaaca
     4801 aaaaagtttt tttcaatctt atctggaagt tctttcataa cttgtttttt acttcttcta
     4861 agaataaaag gttttatcaa ttttttcagg tttttaacat tatcttcttt atttataaac
     4921 aattcctgaa actttgcttt actatataga tagccaggca ttataaaatc aaatatagac
     4981 cataattcta gtagattatt ttccataggt gtaccagtga gtgcaaattt attttctgca
     5041 tttatacttt ttacagactc agttactaaa gctactggat tttttatatt ttgagcttca
     5101 tctaatatac aataatcaaa ctttatttca ctatattttt ctaaatcatt tctaagagta
     5161 ccatatgttg taagtattac atcaaaattt tctaattcca taaaacattt ttctctatct
     5221 cttttatttc catgtatcaa taaaactttt atatctggag caaacttttc aaattcattt
     5281 ttccaattat aaatgagtga tgtcggtgta acaataagac tttttttatt agataatgat
     5341 aataaaaatg caatagtctg tattgtttta ccaagaccca tttcatcagc taatatacca
     5401 ccaaatttat aataatctaa aactttaaac caattgaggc catttatttg atagtcacga
     5461 aggtttgcat ttaaatttgc gggaatttct aaatttatgc tatcaaaatt tctaaatttt
     5521 tcacatatac tgtctagttc ttttttacca tctataaact ttaaattttt actacgtatt
     5581 acatcattta tatatagagc tttattttta tgaattttat tattttttga tttatccatt
     5641 atatctagat tttcaactaa ttcaaaaaaa tcttttgttt ctctttctga taaatctata
     5701 aagtttccat ctttaagttt ataaaaagta cgtttttctt gaaaagcttt caaaatatcc
     5761 ttgtactctc ttggatttat atcagatata ttaaaattaa attctaggta attctggtta
     5821 gtctgattga ttgaagcttg aattgatgaa gcgttatata tttttttcaa tttaaacttc
     5881 tcagaataat atatatctcc aaattccttt agagattcta attgtaaatc taaaaatgta
     5941 aataggtcat ggtcagttcc tttaaacaca taatgattat tttcctttgt aaattgtgaa
     6001 gaagtaagtt tattttcaat agtagcttcc ttttgtatgt tggggagcac aaatttttta
     6061 tcttcatcat catatatata ctttacatca caacatatgt tgccatcaat catatcaaag
     6121 tagaactcag atttaaaatc ttttgttata ttatttttta tgttatcatc taaatgaact
     6181 tcttgagata tagattttaa tctaggaact agcaatccta aaacatcctt agaatcctct
     6241 ttatcaaatt ttaactcttt agtctttgat aatatttgat atatttttga ataatcatga
     6301 gcttttttat gtgataataa atagatattg ccatcatata aaagtacatc atttttttta
     6361 gtaagtggaa caggtagtga atctttagaa tataagacta ttttatcttc tatattttta
     6421 aaatcaaacc ttacaggtag agtatcattt aatatctttg gatgatattc ctctttagaa
     6481 aaaataaggg taaaatcctt gtacttaata gcatttaaaa attgttttaa agagcttgca
     6541 tttatctcca taaatttttt tgaatgtgat gaagaaaagt tgtatgaaag atttgtccca
     6601 tattcttcta taatatctac taacttctca tcttcatcag caaaataatg agtgttgggg
     6661 ttgtaagtaa atttcttccc aaaatctaat tcatatccat taagttttga atatgcaaat
     6721 tcagtaatgt tttttaaaat gtacatttta tcaattccta ttttaaattc agcaattgct
     6781 ttatttgaat ccacatttat caatacatct aaattaaccc tttctctttt agtattgtct
     6841 aacaaagaaa gtaattgctt gcttaaatct aagctggttt tagaatttgt attagaaagc
     6901 ttatccttat ctgcacctaa tatatctatt agaataggag gaacatcttt tttatttttt
     6961 atttgtttta agctttttat cacaatagca actatatgct tacatataaa aatacttttg
     7021 ccctttgatt gacagtcagc gcaactacaa tcattttcaa ttatcttaaa gtgctttata
     7081 tctatagtta ttgaattaaa ataaaagcta taattatctt cagaattgac tccaccacga
     7141 aatgtcaaca ggttattttg taggtcatca atatctatgt ctatataatc aactaattga
     7201 ttagtataat attttacacc tcttgaccat cttgatggtt ctgtatttct tcttattagt
     7261 ttatatatca tatctatttt catattattc accttacctc actgtatata ttataatcta
     7321 aatgcattca atttacactc taaatttaag actaaaatta aggcagatat gaatagcttt
     7381 tatctatcac aatatatgtg taaataacaa tttactatta gatttttatt gaattatctt
     7441 ataaactatg aatgaaaaat aattatataa atagattatt aataaatata aaatcttatt
     7501 attaaaaata ttcttagaaa ttacactata taaaatataa agtatgatat ttgaataaaa
     7561 agaatgtata ataagtataa taatttgtat ttattattgg gaaaggaaaa tgttaatatg
     7621 gatagttata gacaacttaa agctaaaata ccctgtaagg aaacaggtat agaaataaag
     7681 aggactttat gtgatatttg ttctccagga gtacattgtg gaattgatgc atatgttaaa
     7741 gatggtaaag taataaaaat agaaggtaca aaagaacatc caatgaataa agggttgtta
     7801 tgtaccaaag gtctttgcaa tagagaatat atctatagag aagatagaat aaaaacacct
     7861 ctaaaaagaa ttggaaaaag aggtgaagga aaatttaaac caatatcatg ggatgaagct
     7921 tatagagaaa tagcagaaaa attaaataga gtaaaatctg agtatggagc aaagcatgta
     7981 gcttttttta cgggttatgg aaagtggtat agaccttttt tacaaaggtt tgcatcttca
     8041 tttggttcac ctaattatgg tacagaatct agttcatgtt caacatcagc acagatggct
     8101 ggaaatgttg ctactggaag aaactttaca atgcaagata tggagaatgc aaaaacttat
     8161 ttagggtggg gatttaatcc atactactct aaatttttaa atagtgtgaa tctaataaaa
     8221 ttaaaagaaa aaggtctaaa atttataatt gtagacccta gaataacacc gacaactcaa
     8281 aaactagcag atttacattt aagaattaaa cctggaactg atggagcttt agctcttgga
     8341 atggcgaatc tatttataca aaaggattta atagatagag aatacataga aaagcatgta
     8401 catggattta atgaatataa agaatatgta aaattatttg atttagatac tgtaagtaga
     8461 attacaggag tttctaaaga taatatagta aaagctgtcg agatgttgtc acaaggtcca
     8521 ttttgtataa atgaaagtgc agctccaata gttcaccatc aaaatggatt tcaaaattat
     8581 agagcaatga tgtctttatc cgctataaca ggtaattatg atagaatagg tggaaacata
     8641 ccaaaacaag attactttgc tggtaagata ggtggattcc aaacactaga aaaagagttt
     8701 gtaaaagaag ttctacctaa aaatataaat gaaagaattg gtggagaaag atttcctcta
     8761 tggaatgaaa tggtgactca atttcaagct atggatttac ctaggcaaat agaagaaaag
     8821 acaccatatg aaataagagc tttgttttgt catgggataa atgctagaat gtttactaat
     8881 tcagggagac tttttaaagc gttgaatagt gtagattttt ttgtgaatat agatttattt
     8941 atgacagata catcaaaata tgcagatata cttttacctg catgtacatc atttgagaga
     9001 gaagaatgta agagttatcc aggagggtat attacatata ccaaaaaagt tattgataaa
     9061 ttatacgatt caaaatcaga tgtagaaata ctttcagatt tagcaaatgc tatgaatata
     9121 gatgatgatt tattaaaagc aggttatgaa gcaagtataa gacatatgtt taaaaataca
     9181 tgtgtagatg tagataaact taaagaaagt gatttaccat taaaatgtaa agattttaag
     9241 ccatatatag taggttcata tacaagagaa gggtatgata ctagcacttc taggtttgaa
     9301 ttaaaatcta caattattga aaaatataaa gattttgggc tggatgcact accaacatat
     9361 agaggattta atgataatat agatgatgaa tatactcatt tattgacatc aggagcaaga
     9421 atttcaaatg cactacattc aagacttcat gacatcaaac tttcaagaat attaaaaaat
     9481 gaagctagtt gtgatatttc tagcttagat gcaaaagaat tgggtgttat cagtggagat
     9541 tatataaaaa taactactaa gataggaagt ttggatgtaa aagtcaatgt tactgataga
     9601 gtcttatata agaatataca tatgtatcat ggatatagag aagctgatat aaatagtatt
     9661 atttgtgata attttgaccc ttatagtgga ttccctgcgt atagaagttg taagtgtaag
     9721 attgaaaaaa tgaatagata aatggagaga tataatgaaa agtttattta aatttaataa
     9781 agaattatgt acagcatgtg gagcatgttt gcttgcatgt atagaccaaa atgataataa
     9841 tatagacaat ggtgaacttt ttagacatgt atttacaata gaggaaggtg aaaatataga
     9901 atatttttca ttagcatgta tacattgtaa tgagccaaaa tgtttaggtg tatgtcctaa
     9961 aaattgtttt aaaaaagaag aaggattcat tgtattagac aatcaaaact gtatagggtg
    10021 taaactttgt gaaaaagctt gtgaatatgg agccttaatt tatggaaatg atggtaaggc
    10081 aaataagtgt aatggttgta ttgagagata taagtgtggt atggattcac cttgtgtaat
    10141 ggtatgtcct acaggagcat taaaatttaa taaataaatt aaatatagag aatgacttat
    10201 acttaggtat aagatatttt tacaaaaagc tgtattgagt ttgttataat gaaaactcaa
    10261 tatagctttt ttatggatat agttggatac tataatgtga ttcttagtaa tagttttttg
    10321 ctattggaca aagactgtaa aacatattaa acttatgttg ttcaaagtcg aagtataata
    10381 taataactag aaaattggtt tatagtgcta taaaagcaaa tttagtaagg tataaaatca
    10441 gaggcaatcc tttactataa tatcaatatt tgggagttct gttattgcag agctattaaa
    10501 caattataat ggtacaagtg attcaacctt tgaaaatgta ttatataaaa aattaaaata
    10561 agattaaaaa ggagagaata aattatgaaa aaacttaaat taattattat gtttgccttg
    10621 gtatcagcac tgttagttac aggatgttca tcaggaaata ataaaaataa agaagaacaa
    10681 aaagttataa gagttgcaac atcaggaaca tattaccctt ttgcttttaa agataaagat
    10741 aaacttaaag ggtttgaagt agatttttgg gatgaatttg ctaaacgaac taattgtaaa
    10801 gttgaatggg tattaactga ttttagtgga ttatttggat tattagaagc tgataaagca
    10861 gatgttgtat ctgctcaact tactgcaaca cctgaaagag agaaaaaata tgctttttca
    10921 gatgcttata attatagtgg aacaaacatt attgttagag aagatgatac tagtataaaa
    10981 tcaatagatg atttagttgg caagaaagta ggtgtgggta ctggagcagt agcaaatgaa
    11041 atattaaaag aaaaataccc aaatgatgaa ataaaaatag taaattattc aagtgcgact
    11101 cttaaaggga attatcaaga cctagaaatg ggaagattag atgcagtagt tgcgcaggat
    11161 gttgaggctt taatagctat aaaagaacaa aaattaaatc ttaaaatgat agaacctcca
    11221 attcaatttg gtgcctgttc ttttgcgctt caaaaaaatg aaaaaggtga aaaatggaca
    11281 aaagaaatta acgaagtaat tgaagagatg tataaagatg ggactttgac taaaatatct
    11341 gaaaactggc taggaaaaga cattactaag gagcctatta atgagtaatt ttaattttga
    11401 attttgtcta agtatatttc catttttgat taaagcattg ggaataacaa tactaatatc
    11461 tattgttgca ttttttttat caatattatt aggtgtaata cttgcctttt tcacacagac
    11521 aaaatcaaaa gttttacaat acataacaag agtgtatgtt tcattcttta gaggaacacc
    11581 acttttaatt caaatatttt tcttttattt tggatttcca atgatatttt cttttatgaa
    11641 agattgttca ccttatttag caatagtaat ttgtttaggt gtaaattcat ctgcatatat
    11701 ggctgaaatt atacgagcat ctattgagag tgttgataaa ggacaacagg aagcatgtta
    11761 tgcttttggg ttaagtaaat atcagtcaat ggttaaaata attctacctc aagcagctac
    11821 atctgcagta cctcctattg taagctgtac actggacata attaaaggtt cttctttagg
    11881 tttaactata ggaatacaag atttaatggg agtagctcaa gtagaggctg cttcaagttt
    11941 taaatatttt gagatatata tgataacgat attaatttac tgggcagtat ctataatatt
    12001 gagtaatata caaagcaaag ttgaaaaaag aataagaaga gcatattaga tttcaatatt
    12061 taaaaatggg atgatataga tatattatta cttgtaaata aatttttaat tttagaaaaa
    12121 taaacttagt aatctaaatt attgagaaaa tatagtatca aaatggactg tataatcaag
    12181 ttaaaaaata gtttttctat tgaaaaaata aataaaattc tattgtaatt taatatgcga
    12241 taaagtttta taaaaaacaa cattaagcta gggggactta ttttatggct tttaatatga
    12301 aatatttttt agaattattt ccaacaataa tgaaatcgtt caatgtaact gtgattttgg
    12361 caataagttc attagtattt tcattaatta taggtacaat agtagcgtta tcatcttatt
    12421 acaaagtgaa agtattgaat caaatatgta aagtatatgt atctattttt agaggtacac
    12481 ctcttatgcc acagttattc tttttatatt ttggactagc atatatgagt gattttgtta
    12541 aaaatatgga cccagtattt gcaacatcta tagtacttag tttaaatatg ggagcttata
    12601 tgtctgaaac gataagggca tctatacttt caattgatac aggtcagata gaagcagcat
    12661 atgcaatggg attaacaaat ttacaaacaa tgaaaaggat agtgatacca caggccgtaa
    12721 gagttgcact gccatcatta ttcaataatt ttatagattt aattaaaggg tcttctgtag
    12781 cttttgttgt tggagtaaat gatataatgg gtgctgccaa atcacaagga gcgttgagtt
    12841 ttaagttttt tgaagtgtat ggagcagtta tggtaattta ctggtgtata ataactcctt
    12901 taggttgggg gcaaaaaaaa ttagaaaaga aaataagcaa ttattaagtt attaagaaaa
    12961 tacataaaag tatttttata taaaaaatgg tgtgaggaga agagatatga taaaaagaaa
    13021 tattataaaa tgtttagtgg cagttttatc gttaacgttt gtaattactg gttgttcaaa
    13081 aaaagaggaa gtaaagaatg aaaaagttat aactgtagct tcatctaatt cagctgaccc
    13141 atattcttat gttgataatg gtgagcataa gggttttgaa gttgacatgt ggaaagagat
    13201 tggtaaaaga agtggatata agataaaaat ggaaccaaca ggttttagtt ctatatttgg
    13261 tatgttagat tctggtaaag ttgatgtggc agccaacttc tttggaatgt ctaaagaaag
    13321 attagaaaaa tacgatgctt ctatacctta tggttctgat tctgtgtgta tagctgtaaa
    13381 agatggaaat aacgaaatta ataagcttga agatttaaag ggaaaagttg tagcagtttc
    13441 agaaggttct caaggtcaac aggttgcaac tagtgttaat aaagataatt tgtttcaaga
    13501 aaaggtttac ggtgatggaa ctagtggtct tcaagattta gatttgggaa gagttagtgc
    13561 atggattgat gcagagctta ctattgtggg agacgctaaa aaagctaata tgaaagtaag
    13621 agtattagat aaaaaattat cagctactaa tatagcatac ttctttaaga aaaacgatga
    13681 taaatctaaa acgataaaag aagatgtaaa caaagcaata gaagaaatgc ttgcagatgg
    13741 aacagtgaaa aaaatatctg aaaaatggtt tggaatggat gtaagtgctg atatacaaaa
    13801 ataaatactt taaaattaaa atgtaaaact gtgataacta tagataagta tactaaattt
    13861 atctatagtt atctgtgtat tacaatgtat ttagattagt ctttataaat caaaatgagt
    13921 tatggaggta ttgcaaatga ttgaaactaa aataaaatcc attgcactaa aaaatagaga
    13981 aaaaattata aaaataagac gacagataca cagtaatcca gagttagcat ttaaagaata
    14041 taaaacatct aaacttataa aagaagagct aaataaactt aatatagaat acataaatat
    14101 tgctggtaca ggagtattag ctactataaa aggaaaaaat aatggtggaa aaactatatt
    14161 actcagagcg gatatggatg ctcttccaat caaagaggaa aatgatttag aatttaaatc
    14221 aataaatgat aatatgcatg cttgtgggca tgatgcacat gtttcatggt tgttaggaac
    14281 agcaatgatt ttaaatgaca taaaagaaga attgaatgga aatgtaaaat tactatttca
    14341 acctggcgaa gaaaaaggtg gttctgatat tgtaattaaa gaaaatgtac ttgaaggtgt
    14401 ggatgcatta gcgactggtc attgttggcc aactattgag tcaggaaaaa ttggaatcgc
    14461 tagaaattgt gctatggcag cgactaatac ttttgaaata acaataattg gcaagggtgg
    14521 gcatggagca gagcctcata attgtataga cccaattgca gttggaaatg cagtatattc
    14581 atccattcaa cagatagttt caagaaaaat tgacccagtt gtacctgtag tagtgtctgt
    14641 ttgttctttt aattctggtg tttctaaaaa tataatacca gatgtatgta cacttcaagg
    14701 gactattaga gcgataagca aggaacaagt aattgaagta agtaaaattc tagaatatat
    14761 agtaaaaaat gtatgtaaag cacatggagc agattgcaaa tttgaaaaga gtacaggagg
    14821 agatgctgtt ataaatgaca aaaacatgat agagatagga agagaaagtg cttgcaaaat
    14881 acttggagct gaaaatgttg aaataattga ttttcctgca atgacaggtg aggattttgc
    14941 tatttatatg aaagaaaaac ctggtttatt tatgtatata ggtgtaggag ataaagaaaa
    15001 aaatataaat tacagattgc atagtaacaa gtttaatata gatgaaaaat gtcttagtat
    15061 agcaccttca ttattttcac aacttacagt agattattta tgtcaactat agagtacatt
    15121 cataaaaata tatttagcct atttttaaat ttaatgctag tatattaatt ttgatgtaga
    15181 acatattatt tattatattt atttaaaaag gtggataaca atgataaaag tagaaaattt
    15241 acataaaagt tttaaaggga cagaagttct taaaggtata aatttagaga taagtcaaag
    15301 tgaagtagta gctatacttg gatcatctgg aacaggtaaa tctacgttac ttagatgttt
    15361 aaattattta gttgagccta caaaaggaaa gataatgatt ggtgatgtaa aagtagatgt
    15421 agaaaaagca acaaaaaaag atataaccaa tttaagaaaa catacatcta tggtgtttca
    15481 aaattataac ttatttaaaa ataaaacagc attagaaaat gtaatggagg cattgatagt
    15541 agttcataaa aagagtaaga aagaagctag agaaatatct ttaaaattaa tagataaagt
    15601 aggtatgttg gataggaaag atttttatcc atcaaagttg tctgggggac agcaacaaag
    15661 gataggtata gcgagagcga tggcagtaaa tccaaatgta atattatttg atgagcctac
    15721 atctgcactt gacccagaac ttgttggaga agttttaagc gttataaaat ctcttgcaaa
    15781 agaaggtata acgatgctta ttgtaactca cgaaataaat tttgcaaaag aagttgctga
    15841 taaaattata tttatggata atggtgtaat agctgaagaa ggaactcctg atgaaatatt
    15901 taataatcct aaaaatgaaa gaacagcaaa atttttaaat atcattagga aagaagaagt
    15961 atttagttaa aagtgtataa attaagcatt agaagatatg taagataccc ccattaaatt
    16021 tataagttag ataataaatt taatgggagt atatttttat tattagattt attatttaat
    16081 ttaaaattag aaatgtaact atttgaaaat tctttttaaa agtatatcaa aatatcaaat
    16141 acataaaaaa ataatatttg acaaagtatc atatgtgttt acaaaatcaa ctttatggag
    16201 ttatatagta taggaattac aatgaatata ctaaaatttt atattaaagt acaaagtatt
    16261 aaatttgaaa ataattaagt aatattatat atattttttt atattgtttg ttttattaaa
    16321 attaatctag aaaaaaagtt ttaaaagcag aattttatta atatttatat atagatatga
    16381 actattaata aaacgttaaa aatacaaaaa aactatagaa attgacatat attccagtat
    16441 ttgctaaagt agctgttggg gaaaattaca aaaattatta atgcgcatta gataatttac
    16501 tttaattttt ttagcatttg gggtaattta taatataaag cattagaaag gaaaatataa
    16561 atgagggact ttttaaaaaa ttataagtca tcaattatac ttttagcatg tactatagta
    16621 ggggcgatag taggattagt acttggtcca aaagcttcaa tactaaaacc atttggagat
    16681 ttattcataa atgctctatt aatgatagta gtaccattag tttttcttag tgtttcttca
    16741 ggtgttgcta gtataaaaaa tatggaacga tttggaaaaa taatgaaggg tacagctata
    16801 gtatttatgg gaacaacact tgtaattgca tttttaggta ttacatctgc attattattt
    16861 aatccgtcta aaggattaga tgtatcaagt gtaaaaaatt taatggtgac tcaagatgca
    16921 gaaactttag aatcaaaagg aacgttatta gaccaagtag tatcaagtat tacagttaaa
    16981 aattttggag atttattttc cagtagtaat ttactacaat tagttatatt tgcagtttta
    17041 attggaacag caatagctat gatgggagat aggggaaata caataagaaa gcttttatca
    17101 gaaggaacgg aagcaatatt aaaagtagta agtatattca tgctttatgc tcctataggg
    17161 ctaggctgtt atacagctac aataattggg gaacttggaa gtaaaataat tcaaggatat
    17221 gtaagggtgt ttgtaattta ttcactaaca gcagccatgt atttcttatt attttacagt
    17281 ctgtatgctt ttttatctgc aggaaaacaa gggtttagac aattctggag aaatgctata
    17341 aaaccaatag caacggcact agctacttct tcaagttcag catgtatacc atcaaattta
    17401 gaagctagta aaaatatagg agttcctgat gatatatcag aaacagttat acctcttgga
    17461 ataaatatac ataaagatgg gtcagtttta gcagtaataa taaaagtggc atttttatca
    17521 ggtattttag gtagtggaat ggcaaatcca gcaacgatag gtcaattatt tataactgta
    17581 tttgttgttg gagtatttat ggctcctgta gcaggtggct gacttattgg tgagatgctc
    17641 gtggttagca tcttcggttt tccagtggag gcaattccac tgttaacagt tataactact
    17701 ataactgata ttcctaatac tatattaaat acaactggaa atacagtatc atcaatgtta
    17761 gtttcaagat tagtagaagg aaaagattgg cttatagata aaacagcaat tactacaaag
    17821 aaaataagct aattgtacac ttaattaata aagttaatag gtatcttaat tttaataaat
    17881 tagataccta ttaacttttt aagtaaaaat ataaatttaa gattcaaata tgatatttat
    17941 aatttgaatc aactaatata gtatatattg aaataaatat gtttaaatat ctattttatt
    18001 ttttaaaata aaagatttca aatttatttt tgttaaaaga taacaagcct tcatctcgca
    18061 tcttgccaag ctctcttgac atagaacttc tgtcaacaca taaaaaatca gccatttcat
    18121 ttcttgaaaa gggaattgta aactggtggc tacctgtttg ttctatctgt tttgaaaaat
    18181 acataagcaa tttctcgcga gttgttttac gagaaagtaa ttctatttta ttgtgaagta
    18241 aaatgttttt ttcagctatt aattgtagca tattttcaac aagcctatta tgaaatacac
    18301 atgcagatga acaaatacca gttacacttt taaactttat gaataaaact tcgcaagaag
    18361 atgttgtggt tactgtaaca ttacttttat gtagtctagt acatgcgaat acctctccaa
    18421 ataaatctcc aggcaagagt tcagctacaa tattcctatt cccttcgata tcttccttta
    18481 ttatatgagc acttccttta agcataattc caatagaagt aacttcactt ccaacagaga
    18541 atattatact atcttttgtg taagtcttat ctacaacacc taaacattcc aacatttctt
    18601 caagttcatc acttttaatt ccttcaaata gaggaatttt tttaagtagg tctatatgct
    18661 tttctaaaaa ttttttcaaa taatcacttc cttgttgcat atgcaaccga taatttgttt
    18721 tcattgtact atactaagtt tataaaagca aggggatata aaaatcctac tacaagaaat
    18781 ttgaaataaa gaaatatagg tattaaaaat atatatataa gaaatcaata ctttaaatta
    18841 aaaaaatttt atgaggtgat ataaatgatg agaaaaataa ttaaaattga tgaggaaaag
    18901 tgtaatggtt gtggactatg tgttgaagct tgtcatgaag aagctatagg aatggtaaat
    18961 ggaaaagcaa aacttttaag agatgactat tgtgatgggc tgggagattg tctgccaact
    19021 tgtccaacaa atgcgatttc atttgagtat agagaagcag cagaatatga tgaagctgca
    19081 gtaaaagcaa atatggaagc aaagaaagca caaaagaaaa ctttagcatg tggatgtcca
    19141 ggttctcagt ctaagtcaat aaatagagag gtttcaaata gtatgtctat aagcaatgat
    19201 atagtagaga taaaaggttc tcaacttaat caatggccag tacaaataaa attagtacca
    19261 actaatgcat catatttaaa gaatgcaagt cttttaatag cagcagactg tacagcgtat
    19321 gcatatggaa attttcataa taaatttatg aaaaataagg ttacattaat cggatgccct
    19381 aaacttgatg aagttgacta tgctgaaaaa cttacagaga ttttaaaaga aaatgatatt
    19441 aaaaatatag tagtaacacg tatggaagtt ccttgctgtg gtggtatagt aaatgctgtt
    19501 aagacagctc tacaaaatag tggaaaaatg ataccatggc aaatagttac tatatctgta
    19561 gatggaaaaa ttgtagatgg agaaatttaa ttaagtgaat tatagaaaaa tataataaat
    19621 tttaataaat aaaaagggag gaataaaaaa tggaaaaaat gttttgtttt caatgtgaac
    19681 aaacagcagg aggtaaaggt tgtactataa atggtgtctg tggtaaaaag gggggtacag
    19741 ctaacttaca agacgaactt acaggagtgt tgattggtct ttcaagagca actattggaa
    19801 ataagaatag accaacaagt gaaacagata aaattatgat agaggggcta ttcactacta
    19861 taacgaatgt aagttttgat gatgaagcta taaaaagaca aattgaaaaa actgaggtag
    19921 aaaaaagtaa gcttgtacct agatgttcag attgttcaac aacttgtaat agaaatgata
    19981 actatgatat gaaggattta tggaatgata atgaggacat acgttcatta aaatcattaa
    20041 tcttatttgg attaagaggt atggctgcct atgcatatca tgcaatggta cttggttata
    20101 cagacaaaga cgtaaatgaa tttttctatg aaggattaat agcagttgga ggagacttgt
    20161 ctattgacga acttttaggt ctagttatga aaactggaga aataaactta aaatgtatgg
    20221 aattgcttga tagagcaaat actgaaactt atggaacacc agaaccgact caggtatcta
    20281 tgaaaatcga gaaagggcca tttattgtag ttacaggaca tgacctttat gatttacaca
    20341 aattattaga acaaacgaaa gataagggta taaatatata tactcatggt gagttattac
    20401 cagcacatgc atatccaaaa ctaaaagaat ataaacatct aaaaggtaat tttggtacag
    20461 catggcaaaa ccagcaaaaa gaatttgata atattcctgc tccaatatta tttacaacaa
    20521 actgtttaat gcctgttaaa gatagttata gagatagagt atttactaca gaagtagttg
    20581 cttatccagg tatggttcat attgatgaag ataaagattt ttctagtgta atagaaaaag
    20641 ctcttgaact tggaggatat agagaagatg ttcatatgac tggtattaat ggaggagata
    20701 cattaactac tggttttgca agaggtacag tttcatctgt acaagataaa gtagtagatg
    20761 ctgtaaagag tggagctata agacactttt tattggttgg aggttgtgat ggtgcaaaac
    20821 ctggaagaaa ttattacact gaatttgtaa aacaagctcc taaagacact gttatattga
    20881 cacttgcatg tggaaaatat agatttaatg atttagacct tggggatata tgtggcttac
    20941 ctcgtttaat ggatatggga caatgtaatg atgcttatag tgcaattaaa gtggcagttt
    21001 cattggcaaa tgcttttgaa tgtggagtaa atgatttgcc tcttagcatg gtactgtcat
    21061 ggtatgagca gaaagctgtt tgtatacttc ttacactact tcatttaggt atcaaaaata
    21121 tctatatagg gccttctttg ccagcattct tatctaagaa tgtattagat atattggttg
    21181 ataaatttgc attgacacct atatctactc ctgaagaaga tatgaagaag attttaggat
    21241 aaataaacat atctatactt aaagatattt atagttaaaa tatttttaag tatgccacaa
    21301 ttaagataag gggttaaact taaaatttga ttaaaaaatc aattttgaga tgacccttta
    21361 tttatttttt gtaataattg aaaaataaac ctgctttcag tatattcttt ttaagaatct
    21421 ttgtattaaa tttataatac ttagatatat aatatcttat atattttatt ttaagtatta
    21481 aaggtttgaa tgtaacttaa atattaaaag aggaacattg taatatgtaa cttgcataaa
    21541 atatatatac tatagtgaaa ttattttgat taaaatttaa aatataaggt gttttatgtg
    21601 ggggtatatg tatatgaaaa attctaattt taatatattg gcatttgatg gtggtggatt
    21661 aaaaggggca ttgagtatat ccatacttga gaggatagta aaagagtatc caaatctatt
    21721 aaacaatata aatatgtttg gaggtacatc tacagggagt ctaattgcac tagggcttgc
    21781 gtatggtgta agccctaaag agataaaaga actttactca attgaaaatt caaagtatat
    21841 ttttaataaa agttatgcag aaatactcag accaaagtat gaaaacaaaa acttaaaaga
    21901 agttttatta agtatatttc cagaggaact agaattaaaa gatttaaata aattagtaat
    21961 gataccaagt ttttatatag gaaatgagga aaatgcatgg aaaccagtgt tttataacaa
    22021 tatgccaaat tcttttacaa agactagcaa agttgtagat gtagcaatgg caagtagtgc
    22081 tgctccggta ttttttccaa catataatcg tcatgttgat ggaggaataa tagcaactga
    22141 cccgagttta gcgtgtataa ttcatgccat tgacagtgga tttaaactta agaatacaag
    22201 acttttttca atagggactg gatatgtata taacagtata aaggcagata ctactgaatg
    22261 gggagctatt gactggataa ttaataaaga acccgattta ccaattatat ctattacctt
    22321 agaaggaaat tctcaaatga gtcagttatt ttctcaaaaa cttcttggag ataattacta
    22381 tagattaaat cctaagatgg aaaaagatgt agctatggat gattgtgatg cattagaata
    22441 tctaatgtct ttaggagaaa attgtgatat aaaagatgct tttggatgga taaagaaaaa
    22501 gagcttttat agaaattaga ttcaatttgc aattgtattt ttacacatga tttcattgag
    22561 taggtaaaaa taataaaatg cagattatta agttacttct tagggaataa ataaagtata
    22621 atttatttaa ggagtgatga aaatgataaa acttgctact tttgcaggtg gatgtttttg
    22681 gtgtatggta aaaccttttg ataagtatga tggagttatt aaagtagttt ctggatatac
    22741 aggtggtcat gttgaaaacc ctacatatca agaggtatgc tcaggaacta ctggtcattt
    22801 agaagcaatt caaataacat atgatgatga tataataagt tatgatgaac ttctaaatat
    22861 cttctggaaa cagattaatc ctacagatga tggtggacaa tttggtgata ggggaactca
    22921 atataagact gctatatttt atcatgatga agaacaaaaa aatatagctt tagagtcaag
    22981 agaacatctg gaaaatagta aaatatttga tagtaaaata gtgactgata taattccagc
    23041 aactaaattc tacgaagcag aagaaaatca tcaggattat tataagaaaa gaccattaaa
    23101 ctacaatatg tattataaag ggtctggaag atataatttt gtaaaaagcc attgggatgg
    23161 aaacaatata aatagggaag agttaaaaaa gactttaact catatacaat ttgaagtcac
    23221 tcaaaatgat atgacagaag taccttttga aaatgaatat tatgacaata acaaagaggg
    23281 aatttatgtt gatattgtaa gtggagaagt gttattttct tcaaaagata aatttgattc
    23341 tggatgtggg tggccaagtt tttcaaagcc agttatagat aaatctatca ttgagagaag
    23401 tgatttctca caaggtatgt acagagttga agtaagaagt gctaaaggaa attctcattt
    23461 aggtcatgta tttgatgatg gtccaaaaga acttggaggt ttaagatatt gtataaattc
    23521 tgcttctctt aaatttatac caagagaaaa tatggaagct ttaggatatg gagaatattt
    23581 aaaacttttt gagtaattag gaatatttat tataaactta tctaaaaggt gaaaatataa
    23641 aaaaatattt tcaccttttg tttttttgtc aataatatga taaattatta attgtaatct
    23701 tatttatacc aatagattaa gaatttaatt ttgaaagaga gaaaacaaat gaatttaaaa
    23761 gactttaatg gaaagagatt aaaatcagct agaattttta gagcaaagac gatagaacag
    23821 ttgtctaaag aaactaaaat aaataaaaaa gatttaaaag cttttgagga aaataagtat
    23881 gtaccaaata tagaaaatac attaaaatta tctaatatat taaattttcc aaaagagtat
    23941 ttttataaaa atgaaaatat aaatatcgtt gtagaggata gccactttaa ccctcaatct
    24001 aaactaccta gagtagaaga gatttcttat agagaaaaaa taattataat acataaaata
    24061 tattcattta tggagaatta tattaagttt ccaaaagaaa acttgccaaa tagaaaagta
    24121 atgtcagata ttaatataaa tgatatagaa tctcttgcat ataagactag agagttttgg
    24181 gatttaaata gtactccaat agtaaatatg gtaagtttgt tagagtctaa agggattata
    24241 atatcaggta tgaatgtaga tagaaaaggg gcaactatct ttactcaaaa acagagaatt
    24301 agtaaagaat ctaaatatct aatatctctg ggtaatgaca aaaagtcagc atcaattaga
    24361 aattatactt tggcatgtga gcttggatat ataatatcaa gtgaattaag aataccaagt
    24421 aagcaatttt cagaagatga gtatgcctgt gcatttttat tgccaaaaga gagtttttta
    24481 aaagatttga ctcatccaga agatttagat tattatgtag aactaaagaa aaaatggatt
    24541 gtacctatat ctgctatgat ttttagagca tataatctag aaaagataaa ttacaaaaaa
    24601 tacaattatc ttatgaatga aatggataaa aaaggctggt tgatagaaga accactagac
    24661 aaaatgaaag gttcaagccc aacgtattta aaaagagcag ttgaattatt gatagaaaat
    24721 aaaataatga gtgtaaatag tatagtatca agtttagagg aatttggaat aaatctttat
    24781 ccagaagact tagaattatt gatgggattg aaaaaaggat tgttatctca agaggtaaat
    24841 aaaaaaagta aagttataaa atttgatggt aaaaaatagg tttatatttt agtattaaaa
    24901 ttaaaagcag gtacaaatga tttaaacatt aacttagtta aaagtctttt caataagtca
    24961 tttacctgct tttagtgtaa gaaagaatat tgaatctaaa gtgtttttga aagtgcaata
    25021 tattccctta aaacagaaca agatttatta aattcgtttt gctcatattc agtcatattg
    25081 atttcaataa tttcttcaat accatctttt cctataacac atggaacacc tgcaaataca
    25141 tttctttcgt tatattgacc ttctagtaat gtagaaactg gaagaacttt tttctcattg
    25201 tgtagtatag cttttacaat ttctactaaa gcagtaccta taccaaattc tgtacaatct
    25261 ttaccattta ttatacttat tcctgttttt ttattttttt caactattga tggtaagtct
    25321 aaattgctat aagtacttgg gttgtctttt atcatgtcta agattggttt accaccaatt
    25381 gaaacatgag accaaggaac catttgagaa tctccatgtt cacccataga ataagcttga
    25441 attgattgtt gagcgattcc agtttcttca gataaaatcc ttctaagtct tgttgaatct
    25501 aaagctgttc cagttccaat gactttgttt ttaggaaagc cagatttttc ccaaatataa
    25561 tttgtaacta catcaacagg attagatatg actacaaata taccatcaaa gccagaatca
    25621 actatgggtt ttactataga ttttatcatt ccaatagttg gtcttagtaa atctaatcta
    25681 gttgtgtttt gtctacgtaa aggcccttct gaagagtctg caacacttat cactactatg
    25741 tcagaatctt tacagtcaga aaaagttcct ttttctatat gtactttatg tggcagatat
    25801 gaaactgcat cagctaaatc taaagcttga gcttttgatt tagattcatc tatatcaatc
    25861 ataaagagtt catcacaaac tccttgagtt attaaactaa atccacaatg agaaccaaca
    25921 tgccctgaac ctacaataga tatttttctt ggctttattg ccattttaaa tcactccccc
    25981 taaaataacg atacattgaa aattatagat gttattaaaa gctgtttttg gatattttaa
    26041 tattctatta tttcagaaaa tttatttaat atgattttat actaaa
//
LOCUS       DAEPID010000052        25758 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.052, whole genome shotgun sequence.
ACCESSION   DAEPID010000052 DAEPID010000000
VERSION     DAEPID010000052.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 25758)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 25758)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..25758
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.052"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            111..665
                     /gene="tcdR"
                     /locus_tag="KR257_002484"
     CDS             111..665
                     /gene="tcdR"
                     /locus_tag="KR257_002484"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434528.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycosylating toxin sigma factor TcdR"
                     /protein_id="HBH0031167.1"
                     /translation="MQKSFYELIVLARNNSVDDLQEILFMFKPLVKKLSRVLHYEEGE
                     TDLIIFFIELIKNIKLSSFSEKSDAIIVKYIHKSLLNKTFELSRRYSKMKFNFVEFDE
                     NILNMKNNYQSKSIFEEDICFFGYILKELSGIQRKVIFYKYLKGYSDREISVKLKISR
                     QAVNKAKNRAFKKIKKDYENYFNL"
     gene            983..8083
                     /gene="tcdB"
                     /locus_tag="KR257_002485"
                     /gene_synonym="toxB"
     CDS             983..8083
                     /gene="tcdB"
                     /locus_tag="KR257_002485"
                     /gene_synonym="toxB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_074049122.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycosylating toxin TcdB"
                     /protein_id="HBH0031168.1"
                     /translation="MSLVNRKQLEKMANVRFRTQEDEYVAILDALEEYHNMSENTVVE
                     KYLKLKDINSLTDIYIDTYKKSGRNKALKKFKEYLVTEVLELKNNNLTPVEKNLHFVW
                     IGGQINDTAINYINQWKDVNSDYNVNVFYDSNAFLINTLKKTVVESAINDTLESFREN
                     LNDPRFDYNKFFRKRMEIIYDKQKNFINYYKAQREENPELIIDDIVKTYLSNEYSKEI
                     DELNTYIEESLNKITQNSGNDVRNFEEFKNGESFNLYEQELVERWNLAAASDILRISA
                     LKEIGGMYLDVDMLPGIQPDLFESIEKPSSVTVDFWEMTKLEAIMKYKEYIPEYTSEH
                     FDMLDEEVQSSFESVLASKSDKSEIFSSLGDMEASPLEVKIAFNSKGIINQGLISVKD
                     SYCSNLIVKQIENRYKILNNSLNPAISEDNDFNTTTNTFIDSIMAEANADNGRFMMEL
                     GKYLRVGFFPDVKTTINLSGPEAYAAAYQDLLMFKEGSMNIHLIEADLRNFEISKTNI
                     SQSTEQEMASLWSFDDARAKAQFEEYKRNYFEGSLGEDDNLDFSQNIVVDKEYLLEKI
                     SSLARSSERGYIHYIVQLQGDKISYEAACNLFAKTPYDSVLFQKNIEDSEIAYYYNPG
                     DGEIQEIDKYKIPSIISDRPKIKLTFIGHGKDEFNTDIFAGFDVDSLSTEIEAAIDLA
                     KEDISPKSIEINLLGCNMFSYSINVEETYPGKLLLKVKDKISELMPSISQDSIIVSAN
                     QYEVRINSEGRRELLDHSGEWINKEESIIKDISSKEYISFNPKENKITVKSKNLPELS
                     TLLQEIRNNSNSSDIELEEKVMLTECEINVISNIDTQIVEERIEEAKNLTSDSINYIK
                     DEFKLIESISDALCDLKQQNELEDSHFISFEDISETDEGFSIRFINKETGESIFVETE
                     KTIFSEYANHITEEISKIKGTIFDTVNGKLVKKVNLDTTHEVNTLNAAFFIQSLIEYN
                     SSKESLSNLSVAMKVQVYAQLFSTGLNTITDAAKVVELVSTALDETIDLLPTLSEGLP
                     IIATIIDGVSLGAAIKELSETSDPLLRQEIEAKIGIMAVNLTTATTAIITSSLGVASG
                     FSILLVPLAGISAGIPSLVNNELVLRDKATKVVDYFKHVSLVETEGVFTLLDDKIMMP
                     QDDLVISEIDFNNNSIVLGKCEIWRMEGGSGHTVTDDIDHFFSAPSITYREPHLSIYD
                     VLEVQKEELDLSKDLMVLPNAPNRVFAWETGWTPGLRSLENDGTKLLDRIRDNYEGEF
                     YWRYFAFIADALITTLKPRYEDTNIRINLDSNTRSFIVPIITTEYIREKLSYSFYGSG
                     GTYALSLSQYNMGINIELSESDVWIIDVDNVVRDVTIESDKIKKGDLIEGILSTLSIE
                     ENKIILNSHEINFSGEVNGSNGFVSLTFSILEGINAIIEVDLLSKSYKLLISGELKIL
                     MLNSNHIQQKIDYIGFNSELQKNIPYSFVDSEGKENGFINGSTKEGLFVSELPDVVLI
                     SKVYMDDSKPSFGYYSNNLKDVKVITKDNVNILTGYYLKDDIKISLSLTLQDEKTIKL
                     NSVHLDESGVAEILKFMNRKGNTNTSDSLMSFLESMNIKSIFVNFLQSNIKFILDANF
                     IISGTTSIGQFEFICDENDNIQPYFIKFNTLETNYTLYVGNRQNMIVEPNYDLDDSGD
                     ISSTVINFSQKYLYGIDSCVNKVVISPNIYTDEINITPVYETNNTYPEVIVLDANYIN
                     EKINVNINDLSIRYVWSNDGNDFILMSTSEENKVSQVKIRFVNVFKDKTLANKLSFNF
                     SDKQDVPVSEIILSFTPSYYEDGLIGYDLGLVSLYNEKFYINNFGMMVSGLIYINDSL
                     YYFKPPVNNLITGFVTVGDDKYYFNPINGGAASIGETIIDDKNYYFNQSGVLQTGVFS
                     TEDGFKYFAPANTLDENLEGEAIDFTGKLIIDENIYYFDDNYRGAVEWKELDGEMHYF
                     SPETGKAFKGLNQIGDYKYYFNSDGVMQKGFVSINDNKHYFDDSGVMKVGYTEIDGKH
                     FYFAENGEMQIGVFNTEDGFKYFAHHNEDLGNEEGEEISYSGILNFNNKIYYFDDSFT
                     AVVGWKDLEDGSKYYFDEDTAEAYIGLSLINDGQYYFNDDGIMQVGFVTINDKVFYFS
                     DSGIIESGVQNIDDNYFYIDDNGIVQIGVFDTSDGYKYFAPANTVNDNIYGQAVEYSG
                     LVRVGEDVYYFGETYTIETGWIYDMENESDKYYFNPETKKACKGINLIDDIKYYFDEK
                     GIMRTGLISFENNNYYFNENGEMQFGYINIEDKMFYFGEDGVMQIGVFNTPDGFKYFA
                     HQNTLDENFEGESINYTGWLDLDEKRYYFTDEYIAATGSVIIDGEEYYFDPDTAQLVI
                     SE"
     gene            8205..8705
                     /gene="tcdE"
                     /locus_tag="KR257_002486"
     CDS             8205..8705
                     /gene="tcdE"
                     /locus_tag="KR257_002486"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434540.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="holin-like glycosylating toxin export protein
                     TcdE"
                     /protein_id="HBH0031169.1"
                     /translation="MHSSSPFYISNGNKIFFYINLGGVMNMTISFLSEHIFIKLVILT
                     ISFDTLLGCLSAIKSRKFNSSFGIDGGIRKVAMIACIFFLSVVDILTKFNFLFMLPQD
                     CINFLRLKHLGISEFFSILFILYESVSILKNMCLCGLPVPKRLKEKIAILLDAMTDEM
                     NAKDEK"
     gene            9034..9216
                     /locus_tag="KR257_002487"
     CDS             9034..9216
                     /locus_tag="KR257_002487"
                     /inference="COORDINATES: protein motif:HMM:NF022413.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0031170.1"
                     /translation="MRDEGQNDIENKYQTLINDLIDSLKVIGKIYKEIKTLKKYKICL
                     QITIRQSPYLIEESIN"
     gene            9433..17565
                     /gene="tcdA"
                     /locus_tag="KR257_002488"
                     /gene_synonym="toxA"
     CDS             9433..17565
                     /gene="tcdA"
                     /locus_tag="KR257_002488"
                     /gene_synonym="toxA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_105161403.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycosylating toxin TcdA"
                     /protein_id="HBH0031171.1"
                     /translation="MSLISKEELIKLAYSIRPRENEYKTILTNLDEYNKLTTNNNENK
                     YLQLKKLNESIDVFMNKYKTSSRNRALSNLKKDILKEVILIKNSNTSPVEKNLHFVWI
                     GGEVSDIALEYIKQWADINAEYNIKLWYDSEAFLVNTLKKAIVESSTTEALQLLEEEI
                     QNPQFDNMKFYKKRMEFIYDRQKRFINYYKSQINKPTVPTIDDIIKSHLVSEYNRDET
                     VLESYRTNSLRKINSNHGIDIRANSLFTEQELLNIYSQELLNRGNLAAASDIVRLLAL
                     KNFGGVYLDVDMLPGIHSDLFKTISRPSSIGLDRWEMIKLEAIMKYKKYINNYTSENF
                     DKLDQQLKDNFKLIIESKSEKSEIFSKLENLNVSDLEIKIAFALGSVINQALISKQGS
                     YLTNLVIEQVKNRYQFLNQHLNPAIESDNNFTDTTKIFHDSLFNSATAENSMFLTKIA
                     PYLQVGFMPEARSTISLSGPGAYASAYYDFINLQENTIEKTLKASDLIEFKFPENNLS
                     QLTEQEINSLWSFDQASAKYQFEKYVRDYTGGSLSEDNGVDFNKNTALDKNYLLNNKI
                     PSNNVEEAGSKNYVHYIIQLQGDDISYEATCNLFSKNPKNSIIIQRNMNESAKSYFLS
                     DDGESILELNKYRIPERLKNKEKVKVTFIGHGKDEFNTSEFARLSVDSLSNEISSFLD
                     TIKLDISPKNVEVNLLGCNMFSYDFNVEETYPGKLLLSIMDKITSTLPDVNKNSITIG
                     ANQYEVRINSEGRKELLAHSGKWINKEEAIMSDLSSKEYIFFDSIDNKLKAKSKNIPG
                     LASISEDIKTLLLDASVSPDTKFILNNLKLNIESSIGDYIYYEKLEPVKNIIHNSIDD
                     LIDEFNLLENVSDELYELKKLNNLDEKYLISFEDISKNNSTYSVRFINKSNGESVYVE
                     TEKEIFSKYSEHITKEISTIKNSIITDVNGNLLDNIQLDHTSQVNTLNAAFFIQSLID
                     YSSNKDVLNDLSTSVKVQLYAQLFSTGLNTIYDSIQLVNLISNAVNDTINVLPTITEG
                     IPIVSTILDGINLGAAIKELLDEHDPLLKKELEAKVGVLAINMSLSIAATVASIVGIG
                     AEVTIFLLPIAGISAGIPSLVNNELILHDKATSVVNYFNHLSESKKYGPLKTEDDKIL
                     VPIDDLVISEIDFNNNSIKLGTCNILAMEGGSGHTVTGNIDHFFSSPSISSHIPSLSI
                     YSAIGIETENLDFSKKIMMLPNAPSRVFWWETGAVPGLRSLENDGTRLLDSIRDLYPG
                     KFYWRFYAFFDYAITTLKPVYEDTNIKIKLDKDTRNFIMPTITTNEIRNKLSYSFDGA
                     GGTYSLLLSSYPISTNINLSKDDLWIFNIDNEVREISIENGTIKKGKLIKDVLSKIDI
                     NKNKLIIGNQTIDFSGDIDNKDRYIFLTCELDDKISLIIEINLVAKSYSLLLSGDKNY
                     LISNLSNTIEKINTLGLDSKNIAYNYTDESNNKYFGAISKTSQKSIIHYKKDSKNILE
                     FYNDSTLEFNSKDFIAEDINVFMKDDINTITGKYYVDNNTDKSIDFSISLVSKNQVKV
                     NGLYLNESVYSSYLDFVKNSDGHHNTSNFMNLFLDNISFWKLFGFENINFVIDKYFTL
                     VGKTNLGYVEFICDNNKNIDIYFGEWKTSSSKSTIFSGNGRNVVVEPIYNPDTGEDIS
                     TSLDFSYEPLYGIDRYINKVLIAPDLYTSLININTNYYSNEYYPEIIVLNPNTFHKKV
                     NINLDSSSFEYKWSTEGSDFILVRYLEESNKKILQKIRIKGILSNTQSFNKMSIDFKD
                     IKKLSLGYIMSNFKSFNSENELDRDHLGFKIIDNKTYYYDEDSKLVKGLININNSLFY
                     FDPIEFNLVTGWQTINGKKYYFDINTGAALTSYKIINGKHFYFNNDGVMQLGVFKGPD
                     GFEYFAPANTQNNNIEGQAIVYQSKFLTLNGKKYYFDNDSKAVTGWRIINNEKYYFNP
                     NNAIAAVGLQVIDNNKYYFNPDTAIISKGWQTVNGSRYYFDTDTAIAFNGYKTIDGKH
                     FYFDSDCVVKIGVFSTSNGFEYFAPANTYNNNIEGQAIVYQSKFLTLNGKKYYFDNNS
                     KAVTGWQTIDSKKYYFNTNTAEAATGWQTIDGKKYYFNTNTAEAATGWQTIDGKKYYF
                     NTNTAIASTGYTIINGKHFYFNTDGIMQIGVFKGPNGFEYFAPANTDANNIEGQAILY
                     QNEFLTLNGKKYYFGSDSKAVTGWRIINNKKYYFNPNNAIAAIHLCTINNDKYYFSYD
                     GILQNGYITIERNNFYFDANNESKMVTGVFKGPNGFEYFAPANTHNNNIEGQAIVYQN
                     KFLTLNGKKYYFDNDSKAVTGWQTIDGKKYYFNLNTAEAATGWQTIDGKKYYFNLNTA
                     EAATGWQTIDGKKYYFNTNTFIASTGYTSINGKHFYFNTDGIMQIGVFKGPNGFEYFA
                     PANTHNNNIEGQAILYQNKFLTLNGKKYYFGSDSKAVTGLRTIDGKKYYFNTNTAVAV
                     TGWQTINGKKYYFNTNTSIASTGYTIISGKHFYFNTDGIMQIGVFKGPDGFEYFAPAN
                     TDANNIEGQAIRYQNRFLYLHDNIYYFGNNSKAATGWVTIDGNRYYFEPNTAMGANGY
                     KTIDNKNFYFRNGLPQIGVFKGSNGFEYFAPANTDANNIEGQAIRYQNRFLHLLGKIY
                     YFGNNSKAVTGWQTINGKVYYFMPDTAMAAAGGLFEIDGVIYFFGVDGVKAPGIYG"
     gene            complement(17900..18598)
                     /gene="tcdC"
                     /locus_tag="KR257_002489"
     CDS             complement(17900..18598)
                     /gene="tcdC"
                     /locus_tag="KR257_002489"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860905.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycosylating toxin anti-sigma factor TcdC"
                     /protein_id="HBH0031172.1"
                     /translation="MFSKKNDGNEFSNEGKGSSKKIIKFFKSTKGIALLAFILGVFFG
                     NISSPACSEDHEEVISNQTSVIDSQKTEIETLNSKLSDAEPWFKMKDDEKKAIEAENQ
                     RKAEEAKKAEEAKKAEEQRKKEEEEKKGYDTGITYDQLARTPDDYKYKKVKFEGKVIQ
                     VIEDGDEVQIRLAVSGNYDKVVLCSYKKSITPSRVLEDDYITIRGISAGTITYESTMG
                     GNITIPGIAVEKIN"
     gene            19024..19269
                     /locus_tag="KR257_002490"
     CDS             19024..19269
                     /locus_tag="KR257_002490"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418186.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Pathogenicity locus"
                     /protein_id="HBH0031173.1"
                     /translation="MGELQKIPGVGKATEKSLIMLGYTTIKSLKDANPAQMYEKECLI
                     RGQHIDRCQLYVYRCAVYFASTENPEPEKLKWWYWKD"
     gene            complement(19487..19756)
                     /locus_tag="KR257_002491"
     CDS             complement(19487..19756)
                     /locus_tag="KR257_002491"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888452.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3795 domain-containing protein"
                     /protein_id="HBH0031174.1"
                     /translation="MFESRCGVCCDSCTKKEQVNCTGCPTMEKPFWGGECKVKTCCES
                     KELNHCGECDTFPCDMLLNKGKDQGFDPMVNIEQCRKWLEETVSN"
     gene            complement(20634..21371)
                     /locus_tag="KR257_002492"
     CDS             complement(20634..21371)
                     /locus_tag="KR257_002492"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003439186.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBH0031175.1"
                     /translation="MLRKSVLGEILKLKNSFIWYVLLALPLISVLIGSGNFYLNQGIL
                     KKEWYSLWTQVSLFYGEFFFPILIAIFCAYICRLEHMNHNWNNVMTLPVNLKNIFLSK
                     LTVVSILTAITQVFFVIFYIVAGNMFGFSGSVPKELTGWIAKGWIISISIASIQLYMS
                     IKIRSFATPIGISLCLSLFGMGLIVAKPAVGIFFPYSMLGSAMGVIKQSALNVNDTIV
                     TICVAFITTIVFSEIANRNFRKNDVIS"
     gene            complement(21383..22144)
                     /locus_tag="KR257_002493"
     CDS             complement(21383..22144)
                     /locus_tag="KR257_002493"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418193.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBH0031176.1"
                     /translation="MKYLGLEFYKLKRKKIILMTFLFVAVEIMWCIINSNRAITRNPD
                     MLGGFEYSYMFMSFASLNGLFFPILISIITSRISDIEHKGDTWKLLKSSVTSLNSIYL
                     SKFLCSAILVSIPVLMQVLSIVLFGHFRGVIESISVSLLLKYTLGTILVSIAIIALHL
                     WIATVIPNQMIAITFGMIGSFIGLTSGLFYQGIRRLFIWSYYLELSPLSYAYDNVLGS
                     SVYRIDMNFSITILVFLIGMLIYYIGRNHLLKKEV"
     gene            complement(22144..23058)
                     /locus_tag="KR257_002494"
     CDS             complement(22144..23058)
                     /locus_tag="KR257_002494"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860908.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBH0031177.1"
                     /translation="MEMIIRTQRLSKEYNKIFRVKDIDLRVPQGAVYGFLGPNGAGKS
                     TTLKMLLGLAKPTQGNINILGKELNEKNRISILKDIGSLIESPSYYGHLTGLENMTIM
                     QKLLDLPKKNVNEALKIVRLENQKNKKVSQYSLGMKQRLGIAMAIMKFPKLLILDEPT
                     NGLDPAGIEEIRELIKSLPEKYGMTVLISSHLLSEIDQIATSIGIINHGELVFQDSIK
                     ELHNRGQSQIAIKTKNVVSAQKLLNTKGYMSLIQDGYLTIENLKDSDVAKINGMLVHS
                     NIDVFRIEEHKKSLEDIFLELTGKAVTL"
     gene            23229..23936
                     /locus_tag="KR257_002495"
     CDS             23229..23936
                     /locus_tag="KR257_002495"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728652.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HBH0031178.1"
                     /translation="MESIKDKKILVVDDHKELLKMIDEILRKEGFSRVFLASSYEEAV
                     RVFRNVKPDCAILDVVLPDGDGFSIMRKIRETSKIPVIFLSARGEDEDRLIGLGLGAD
                     DYIVKPFLPKELTLRLVGILNRVYVPIEEEELPVFKLGDSVVVNLNSACVEKDGQEIS
                     LTAKEHSLLLKLYENKGRIVTNDSLCQAIWGDDMYGYENTLMVHVRRVREKIEKTPST
                     PKHLITVRGLGYKLMIN"
     gene            23981..25387
                     /locus_tag="KR257_002496"
     CDS             23981..25387
                     /locus_tag="KR257_002496"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892732.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HAMP domain-containing histidine kinase"
                     /protein_id="HBH0031179.1"
                     /translation="MDSVKYILRRFIGSSILISLLFIVLNIAGFLLFSYMLFVSKYSD
                     NLDTSDSREIKSNLIMIEDNLILRNGKFILDDSSKEVLHKNKVWAMLIDNNGDRIWGF
                     DLPKEIPSHYTLTDVAKFSRFFLKDYPVYVWEHPNGILVTGYPKDKYTKFNLTYTVKE
                     IEQFPMLIIGMFLVNAIVTFLIALFIGLKMVKSIKPIITGIKLMSKGEPVLLQEKGIL
                     SDISKSINTVSKELQMKDEKLRKKEEARSNWIAGISHDIRTPLSMIIGYAGELEESSS
                     LSNREQEQVSIICNQGIKIRELVNDLNLVSKLEYNMQALNCDKIRVSAFLRELISEFI
                     NNNLDNDFYVEFDILNEDIIIDADKKLLKRAISNLIQNSITHNQQGCNIRVTSKSDLD
                     FCYIIVEDDGKGMSQERINSLLKSQNGLSEAYAKGQNHGLGILIVSGIINAHRGKLDI
                     TSIDSQGLKTILKLPLIK"
BASE COUNT        10080 a         2985 c         3901 g         8792 t
ORIGIN      
        1 ataaaattta atttatttgc cgattatata attataatga ctgatttaat tccgatgttg
       61 tcaaaatttt caaataaatc atcattataa atataagaga ggatgatttt atgcaaaagt
      121 ctttttatga attaattgtt ttagcaagaa ataactcagt agatgatttg caagaaattt
      181 tatttatgtt taagccatta gtaaaaaagc ttagtagagt tttacattat gaagagggag
      241 aaacagattt aataatattt tttattgaat taataaaaaa tattaaatta agtagctttt
      301 cagaaaaaag cgatgctatt atagtcaaat atattcataa atcattactg aataagactt
      361 ttgagttgtc tagaagatat tctaaaatga agtttaattt tgtagaattt gatgaaaata
      421 tcttaaatat gaaaaataat tatcaaagta agtctatttt tgaggaagat atttgttttt
      481 tcggatatat tttgaaagaa ttatctggta ttcaaagaaa agttattttt tataaatatt
      541 taaaaggata ttctgataga gaaatatcag tgaaattaaa aatatctaga caagctgtta
      601 ataaggctaa aaatagagca tttaaaaaaa taaaaaaaga ctatgaaaat tattttaact
      661 tgtaattaat gagcttaaag aaatatttac aatagaaatc aaattttaga attaacttta
      721 ttgtaaaatc aataacttaa tctaagaata tcttaatttt tatattttat atagaacaaa
      781 gtttacatat ttatttcaga caacgtcttt attcaatcga agagcaaatt aatcaactga
      841 gtgtcttcaa tttaaaatgt taggaagtga atgtatatga aaacctaagt agatattagt
      901 atattttata aatagaaagg aggatatata aaagagtttt atcatttaga tgtaaaaata
      961 ttatagtaaa ggagaaaatt ttatgagttt agttaataga aaacagttag aaaaaatggc
     1021 aaatgtaaga tttcgtactc aagaagatga atatgttgca atattggatg ctttagaaga
     1081 atatcataat atgtcagaga atactgtagt cgaaaaatat ttaaaattaa aagatataaa
     1141 tagtttaaca gatatttata tagatacata taaaaaatct ggtagaaata aagccttaaa
     1201 aaaatttaag gaatatctag ttacagaagt attagagcta aagaataata atttaactcc
     1261 agttgagaaa aatttacatt ttgtttggat tggaggtcaa ataaatgaca ctgctattaa
     1321 ttatataaat caatggaaag atgtaaatag tgattataat gttaatgttt tttatgatag
     1381 taatgcattt ttgataaaca cattgaaaaa aactgtagta gaatcagcaa taaatgatac
     1441 acttgaatca tttagagaaa acttaaatga ccctagattt gactataata aattcttcag
     1501 aaaacgtatg gaaataattt atgataaaca gaaaaatttc ataaactact ataaagctca
     1561 aagagaagaa aatcctgaac ttataattga tgatattgta aagacatatc tttcaaatga
     1621 gtattcaaag gagatagatg aacttaatac ctatattgaa gaatccttaa ataaaattac
     1681 acagaatagt ggaaatgatg ttagaaactt tgaagaattt aaaaatggag agtcattcaa
     1741 cttatatgaa caagagttgg tagaaaggtg gaatttagct gctgcttctg acatattaag
     1801 aatatctgca ttaaaagaaa ttggtggtat gtatttagat gttgatatgt taccaggaat
     1861 acaaccagac ttatttgagt ctatagagaa acctagttca gtaacagtgg atttttggga
     1921 aatgacaaag ttagaagcta taatgaaata caaagaatat ataccagaat atacctcaga
     1981 acattttgac atgttagacg aagaagttca aagtagtttt gaatctgttc tagcttctaa
     2041 gtcagataaa tcagaaatat tctcatcact tggtgatatg gaggcatcac cactagaagt
     2101 taaaattgca tttaatagta agggtattat aaatcaaggg ctaatttctg tgaaagactc
     2161 atattgtagc aatttaatag taaaacaaat cgagaataga tataaaatat tgaataatag
     2221 tttaaatcca gctattagcg aggataatga ttttaatact acaacgaata cctttattga
     2281 tagtataatg gctgaagcta atgcagataa tggtagattt atgatggaac taggaaagta
     2341 tttaagagtt ggtttcttcc cagatgttaa aactactatt aacttaagtg gccctgaagc
     2401 atatgcggca gcttatcaag atttattaat gtttaaagaa ggcagtatga atatccattt
     2461 gatagaagct gatttaagaa actttgaaat ctctaaaact aatatttctc aatcaactga
     2521 acaagaaatg gctagcttat ggtcatttga cgatgcaaga gctaaagctc aatttgaaga
     2581 atataaaagg aattattttg aaggttctct tggtgaagat gataatcttg atttttctca
     2641 aaatatagta gttgacaagg agtatctttt agaaaaaata tcttcattag caagaagttc
     2701 agagagagga tatatacact atattgttca gttacaagga gataaaatta gttatgaagc
     2761 agcatgtaac ttatttgcaa agactcctta tgatagtgta ctatttcaga aaaatataga
     2821 agattcagaa attgcatatt attataatcc tggagatggt gaaatacaag aaatagacaa
     2881 gtataaaatt ccaagtataa tttctgatag acctaagatt aaattaacat ttattggtca
     2941 tggtaaagat gaatttaata ctgatatatt tgcaggtttt gatgtagatt cattatccac
     3001 agaaatagaa gcagcaatag atttagctaa agaggatatt tctcctaagt caatagaaat
     3061 aaatttatta ggatgtaata tgtttagcta ctctatcaac gtagaggaga cttatcctgg
     3121 aaaattatta cttaaagtta aagataaaat atcagaatta atgccatcta taagtcaaga
     3181 ctctattata gtaagtgcaa atcaatatga agttagaata aatagtgaag gaagaagaga
     3241 attattggat cattctggtg aatggataaa taaagaagaa agtattataa aggatatttc
     3301 atcaaaagaa tatatatcat ttaatcctaa agaaaataaa attacagtaa aatctaaaaa
     3361 tttacctgag ctatctacat tattacaaga aattagaaat aattctaatt caagtgatat
     3421 tgaactagaa gaaaaagtaa tgttaacaga atgtgagata aatgttattt caaatataga
     3481 tacgcaaatt gttgaggaaa ggattgaaga agctaagaat ttaacttctg actctattaa
     3541 ttatataaaa gatgaattta aactaataga atctatttct gatgcactat gtgacttaaa
     3601 acaacagaat gaattagaag attctcattt tatatctttt gaggacatat cagagactga
     3661 tgagggattt agtataagat ttattaataa agaaactgga gaatctatat ttgtagaaac
     3721 tgaaaaaaca atattctctg aatatgctaa tcatataact gaagagattt ctaagataaa
     3781 aggtactata tttgatactg taaatggtaa gttagtaaaa aaagtaaatt tagatactac
     3841 acacgaagta aatactttaa atgctgcatt ttttatacaa tcattaatag aatataatag
     3901 ttctaaagaa tctcttagta atttaagtgt agcaatgaaa gtccaagttt acgctcaatt
     3961 atttagtact ggtttaaata ctattacaga tgcagccaaa gttgttgaat tagtatcaac
     4021 tgcattagat gaaactatag acttacttcc tacattatct gaaggattac ctataattgc
     4081 aactattata gatggtgtaa gtttaggtgc agcaatcaaa gagctaagtg aaacgagtga
     4141 cccattatta agacaagaaa tagaagctaa gataggtata atggcagtaa atttaacaac
     4201 agctacaact gcaatcatta cttcatcttt gggggtagct agtggattta gtatactttt
     4261 agttccttta gcaggaattt cagcaggtat accaagctta gtaaacaatg aacttgtact
     4321 tcgagataag gcaacaaagg ttgtagatta ttttaaacat gtttcattag ttgaaactga
     4381 aggagtattt actttattag atgataaaat aatgatgcca caagatgatt tagtgatatc
     4441 agaaatagat tttaataata attcaatagt tttaggtaaa tgtgaaatct ggagaatgga
     4501 aggtggttca ggtcatactg taactgatga tatagatcac ttcttttcag caccatcaat
     4561 aacatataga gagccacact tatctatata tgacgtattg gaagtacaaa aagaagaact
     4621 tgatttgtca aaagatttaa tggtattacc taatgctcca aatagagtat ttgcttggga
     4681 aacaggatgg acaccaggtt taagaagctt agaaaatgat ggcacaaaac tgttagaccg
     4741 tataagagat aactatgaag gtgagtttta ttggagatat tttgctttta tagctgatgc
     4801 tttaataaca acattaaaac caagatatga agatactaat ataagaataa atttagatag
     4861 taatactaga agttttatag ttccaataat aactacagaa tatataagag aaaaattatc
     4921 atattctttc tatggttcag gaggaactta tgcattgtct ctttctcaat ataatatggg
     4981 tataaatata gaattaagtg aaagtgatgt ttggattata gatgttgata atgttgtgag
     5041 agatgtaact atagaatctg ataaaattaa aaaaggtgat ttaatagaag gtattttatc
     5101 tacactaagt attgaagaga ataaaattat cttaaatagc catgagatta atttttctgg
     5161 tgaggtaaat ggaagtaatg gatttgtttc tttaacattt tcaattttag aaggaataaa
     5221 tgcaattata gaagttgatt tattatctaa atcatataaa ttacttattt ctggcgaatt
     5281 aaaaatattg atgttaaatt caaatcatat tcaacagaaa atagattata taggattcaa
     5341 tagcgaatta cagaaaaata taccatatag ctttgtagat agtgaaggaa aagagaatgg
     5401 ttttattaat ggttcaacaa aagaaggttt atttgtatct gaattacctg atgtagttct
     5461 tataagtaag gtttatatgg atgatagtaa gccttcattt ggatattata gtaataattt
     5521 gaaagatgtc aaagttataa ctaaagataa tgttaatata ttaacaggtt attatcttaa
     5581 ggatgatata aaaatctctc tttctttgac tctacaagat gaaaaaacta taaagttaaa
     5641 tagtgtgcat ttagatgaaa gtggagtagc tgagattttg aagttcatga atagaaaagg
     5701 taatacaaat acttcagatt ctttaatgag ctttttagaa agtatgaata taaaaagtat
     5761 tttcgttaat ttcttacaat ctaatattaa gtttatatta gatgctaatt ttataataag
     5821 tggtactact tctattggcc aatttgagtt tatttgtgat gaaaatgata atatacaacc
     5881 atatttcatt aagtttaata cactagaaac taattatact ttatatgtag gaaatagaca
     5941 aaatatgata gtggaaccaa attatgattt agatgattct ggagatatat cttcaactgt
     6001 tatcaatttc tctcaaaagt atctttatgg aatagacagt tgtgttaata aagttgtaat
     6061 ttcaccaaat atttatacag atgaaataaa tataacgcct gtatatgaaa caaataatac
     6121 ttatccagaa gttattgtat tagatgcaaa ttatataaat gaaaaaataa atgttaatat
     6181 caatgatcta tctatacgat atgtatggag taatgatggt aatgatttta ttcttatgtc
     6241 aactagtgaa gaaaataagg tgtcacaagt taaaataaga ttcgttaatg tttttaaaga
     6301 taagactttg gcaaataagc tatcttttaa ctttagtgat aaacaagatg tacctgtaag
     6361 tgaaataatc ttatcattta caccttcata ttatgaggat ggattgattg gctatgattt
     6421 gggtctagtt tctttatata atgagaaatt ttatattaat aactttggaa tgatggtatc
     6481 tggattaata tatattaatg attcattata ttattttaaa ccaccagtaa ataatttgat
     6541 aactggattt gtgactgtag gcgatgataa atactacttt aatccaatta atggtggagc
     6601 tgcttcaatt ggagagacaa taattgatga caaaaattat tatttcaacc aaagtggagt
     6661 gttacaaaca ggtgtattta gtacagaaga tggatttaaa tattttgccc cagctaatac
     6721 acttgatgaa aacctagaag gagaagcaat tgattttact ggaaaattaa ttattgacga
     6781 aaatatttat tattttgatg ataattatag aggagctgta gaatggaaag aattagatgg
     6841 tgaaatgcac tattttagcc cagaaacagg taaagctttt aaaggtctaa atcaaatagg
     6901 tgattataaa tactatttca attctgatgg agttatgcaa aaaggatttg ttagtataaa
     6961 tgataataaa cactattttg atgattctgg tgttatgaaa gtaggttaca ctgaaataga
     7021 tggcaagcat ttctactttg ctgaaaacgg agaaatgcaa ataggagtat ttaatacaga
     7081 agatggattt aaatattttg ctcatcataa tgaagattta ggaaatgaag aaggtgaaga
     7141 aatctcatat tctggtatat taaatttcaa taataaaatt tactattttg atgattcatt
     7201 tacagctgta gttggatgga aagatttaga ggatggttca aagtattatt ttgatgaaga
     7261 tacagcagaa gcatatatag gtttgtcatt aataaatgat ggtcaatatt attttaatga
     7321 tgatggaatt atgcaagttg gatttgtcac tataaatgat aaagtcttct acttctctga
     7381 ctctggaatt atagaatctg gagtacaaaa catagatgac aattatttct atatagatga
     7441 taatggtata gttcaaattg gtgtatttga tacttcagat ggatataaat attttgcacc
     7501 tgctaatact gtaaatgata atatttacgg acaagcagtt gaatatagtg gtttagttag
     7561 agttggggaa gatgtatatt attttggaga aacatataca attgagactg gatggatata
     7621 tgatatggaa aatgaaagtg ataaatatta tttcaatcca gaaactaaaa aagcatgcaa
     7681 aggtattaat ttaattgatg atataaaata ttattttgat gagaagggca taatgagaac
     7741 gggtcttata tcatttgaaa ataataatta ttactttaat gagaatggtg aaatgcaatt
     7801 tggttatata aatatagaag ataagatgtt ctattttggt gaagatggtg tcatgcagat
     7861 tggagtattt aatacaccag atggatttaa atactttgca catcaaaata ctttggatga
     7921 gaattttgag ggagaatcaa taaactatac tggttggtta gatttagatg aaaagagata
     7981 ttattttaca gatgaatata ttgcagcaac tggttcagtt attattgatg gtgaggagta
     8041 ttattttgat cctgatacag ctcaattagt gattagtgaa tagataaaaa tatgttaaat
     8101 atatcctctt atacttaaat atataaaaat aaacaaaatg atacactaca taaagtgttc
     8161 tatctaatat gaagatttac caataaaaag gtggactatg atgaatgcac agtagttcac
     8221 ctttttatat ttctaatggt aacaaaatat ttttttatat aaacctagga ggcgttatga
     8281 atatgacaat atctttttta tcagagcata tatttataaa gttagtaatt ttaactatat
     8341 catttgatac attattagga tgtttaagtg caataaaaag tcgtaaattt aattctagtt
     8401 ttggaataga tggaggaatc agaaaagtag caatgatagc atgtatattt tttttatcag
     8461 tagttgacat tcttacaaag tttaactttt tatttatgtt accacaagat tgtatcaatt
     8521 ttttaagact aaaacatctt ggaatatctg aatttttctc tattttattt attttatatg
     8581 aaagtgtaag tatattaaaa aatatgtgct tatgtggatt accagtacct aagagattaa
     8641 aggaaaaaat agcaatttta ctagatgcaa tgacagatga aatgaatgct aaggatgaaa
     8701 agtaagtaat ggtagatata ataaagatat taacaaataa aaagtgttat ccaaataaga
     8761 atagctgaaa gttatcataa ttcatgaaac taataatgaa aacgagggag cagatgccaa
     8821 gagacacaca agtattaaat acatataatt tcgaagcaag tgttcattac tatatagatg
     8881 acaaggtagt atatcaaaca ttggttcaca aagatggtgc atggtcagtt ggtaaaatct
     8941 attaagctac attagttaca gatatcacaa actataatag ttaaacatag aaatatgtgt
     9001 aaattgtgat ggaaattatt caaaaacaca aaaatacgtg atgaaggaca aaatgatata
     9061 gaaaataagt atcaaacctt aataaatgat ttaattgata gtttaaaagt tataggaaaa
     9121 atatataaag aaataaaaac attaaaaaaa tataagatat gtttacaaat tactatcaga
     9181 caatctcctt atctaataga agagtcaatt aactaattga gtatctttaa attgaaatgt
     9241 taggaagtga tttaaatatg aaaacttaaa ttataaaaaa tcaatattaa tttattttta
     9301 aaaaatagaa aggagtgtat aagatttatt ttcaaagttt aaaaacaaga aaatcaattt
     9361 aaatttcaga aggaataaat gtggttatag aagtggattt attatcaaaa ataataatac
     9421 taggaggttt ttatgtcttt aatatctaaa gaagagttaa taaaactcgc atatagcatt
     9481 agaccaagag aaaatgagta taaaactata ctaactaatt tagacgaata taataagtta
     9541 actacaaaca ataatgaaaa taaatattta caattaaaaa aactaaatga atcaattgat
     9601 gtttttatga ataaatataa aacttcaagc agaaatagag cactctctaa tctaaaaaaa
     9661 gatatattaa aagaagtaat tcttattaaa aattccaata caagccctgt agaaaaaaat
     9721 ttacattttg tatggatagg tggagaagtc agtgatattg ctcttgaata cataaaacaa
     9781 tgggctgata ttaatgcaga atataatatt aaactgtggt atgatagtga agcattctta
     9841 gtaaatacac taaaaaaggc tatagttgaa tcttctacca ctgaagcatt acagctacta
     9901 gaggaagaga ttcaaaatcc tcaatttgat aatatgaaat tttacaaaaa aaggatggaa
     9961 tttatatatg atagacaaaa aaggtttata aattattata aatctcaaat caataaacct
    10021 acagtaccta caatagatga tattataaag tctcatctag tatctgaata taatagagat
    10081 gaaactgtat tagaatcata tagaacaaat tctttgagaa aaataaatag taatcatggt
    10141 atagatatca gggctaatag tttgtttaca gaacaagagt tattaaatat ttatagtcag
    10201 gagttgttaa atcgtggaaa tttagctgca gcatctgaca tagtaagatt attagcccta
    10261 aaaaattttg gcggagtata tttagatgtt gatatgcttc caggtattca ctctgattta
    10321 tttaaaacaa tatctagacc tagctctatt ggactagacc gttgggaaat gataaaatta
    10381 gaggctatta tgaagtataa aaaatatata aataattata catcagaaaa ctttgataaa
    10441 cttgatcaac aattaaaaga taattttaaa ctcattatag aaagtaaaag tgaaaaatct
    10501 gagatatttt ctaaattaga aaatttaaat gtatctgatc ttgaaattaa aatagctttc
    10561 gctttaggca gtgttataaa tcaagccttg atatcaaaac aaggttcata tcttactaac
    10621 ctagtaatag aacaagtaaa aaatagatat caatttttaa accaacacct taacccagcc
    10681 atagagtctg ataataactt cacagatact actaaaattt ttcatgattc attatttaat
    10741 tcagctaccg cagaaaactc tatgttttta acaaaaatag caccatactt acaagtaggt
    10801 tttatgccag aagctcgctc cacaataagt ttaagtggtc caggagctta tgcgtcagct
    10861 tactatgatt tcataaattt acaagaaaat actatagaaa aaactttaaa agcatcagat
    10921 ttaatagaat ttaaattccc agaaaataat ctatctcaat tgacagaaca agaaataaat
    10981 agtctatgga gctttgatca agcaagtgca aaatatcaat ttgagaaata tgtaagagat
    11041 tatactggtg gatctctttc tgaagacaat ggggtagact ttaataaaaa tactgccctc
    11101 gacaaaaact atttattaaa taataaaatt ccatcaaaca atgtagaaga agctggaagt
    11161 aaaaattatg ttcattatat catacagtta caaggagatg atataagtta tgaagcaaca
    11221 tgcaatttat tttctaaaaa tcctaaaaat agtattatta tacaacgaaa tatgaatgaa
    11281 agtgcaaaaa gctacttttt aagtgatgat ggagaatcta ttttagaatt aaataaatat
    11341 aggatacctg aaagattaaa aaataaggaa aaagtaaaag taacctttat tggacatggt
    11401 aaagatgaat tcaacacaag cgaatttgct agattaagtg tagattcact ttccaatgag
    11461 ataagttcat ttttagatac cataaaatta gatatatcac ctaaaaatgt agaagtaaac
    11521 ttacttggat gtaatatgtt tagttatgat tttaatgttg aagaaactta tcctgggaag
    11581 ttgctattaa gtattatgga caaaattact tccactttac ctgatgtaaa taaaaattct
    11641 attactatag gagcaaatca atatgaagta agaattaata gtgagggaag aaaagaactt
    11701 ctggctcact caggtaaatg gataaataaa gaagaagcta ttatgagcga tttatctagt
    11761 aaagaataca ttttttttga ttctatagat aataagctaa aagcaaagtc caagaatatt
    11821 ccaggattag catcaatatc agaagatata aaaacattat tacttgatgc aagtgttagt
    11881 cctgatacaa aatttatttt aaataatctt aagcttaata ttgaatcttc tattggtgat
    11941 tacatttatt atgaaaaatt agagcctgtt aaaaatataa ttcacaattc tatagatgat
    12001 ttaatagatg agttcaatct acttgaaaat gtatctgatg aattatatga attaaaaaaa
    12061 ttaaataatc tagatgagaa gtatttaata tcttttgaag atatctcaaa aaataattca
    12121 acttactctg taagatttat taacaaaagt aatggtgagt cagtttatgt agaaacagaa
    12181 aaagaaattt tttcaaaata tagcgaacat attacaaaag aaataagtac tataaagaat
    12241 agtataatta cagatgttaa tggtaattta ttggataata tacagttaga tcatacttct
    12301 caagttaata cattaaacgc agcattcttt attcaatcat taatagatta tagtagcaat
    12361 aaagatgtac tgaatgattt aagtacctca gttaaggttc aactttatgc tcaactattt
    12421 agtacaggtt taaatactat atatgactct atccaattag taaatttaat atcaaatgca
    12481 gtaaatgata ctataaatgt actacctaca ataacagagg ggatacctat tgtatctact
    12541 atattagacg gaataaactt aggtgcagca attaaggaat tactagacga acatgaccca
    12601 ttactaaaaa aagaattaga agctaaggtg ggtgttttag caataaatat gtcattatct
    12661 atagctgcaa ctgtagcttc aattgttgga ataggtgctg aagttactat tttcttatta
    12721 cctatagctg gtatatctgc aggaatacct tcattagtta ataatgaatt aatattgcat
    12781 gataaggcaa cttcagtggt aaactatttt aatcatttgt ctgaatctaa aaaatatggc
    12841 cctcttaaaa cagaagatga taaaatttta gttcctattg atgatttagt aatatcagaa
    12901 atagatttta ataataattc gataaaacta ggaacatgta atatattagc aatggagggg
    12961 ggatcaggac acacagtgac tggtaatata gatcactttt tctcatctcc atctataagt
    13021 tctcatattc cttcattatc aatttattct gcaataggta tagaaacaga aaatctagat
    13081 ttttcaaaaa aaataatgat gttacctaat gctccttcaa gagtgttttg gtgggaaact
    13141 ggagcagttc caggtttaag atcattggaa aatgacggaa ctagattact tgattcaata
    13201 agagatttat acccaggtaa attttactgg agattctatg cttttttcga ttatgcaata
    13261 actacattaa aaccagttta tgaagacact aatattaaaa ttaaactaga taaagatact
    13321 agaaacttca taatgccaac tataactact aacgaaatta gaaacaaatt atcttattca
    13381 tttgatggag caggaggaac ttactcttta ttattatctt catatccaat atcaacgaat
    13441 ataaatttat ctaaagatga tttatggata tttaatattg ataatgaagt aagagaaata
    13501 tctatagaaa atggtactat taaaaaagga aagttaataa aagatgtttt aagtaaaatt
    13561 gatataaata aaaataaact tattataggc aatcaaacaa tagatttttc aggcgatata
    13621 gataataaag atagatatat attcttgact tgtgagttag atgataaaat tagtttaata
    13681 atagaaataa atcttgttgc aaaatcttat agtttgttat tgtctgggga taaaaattat
    13741 ttgatatcca atttatctaa tactattgag aaaatcaata ctttaggcct agatagtaaa
    13801 aatatagcgt acaattacac tgatgaatct aataataaat attttggagc tatatctaaa
    13861 acaagtcaaa aaagcataat acattataaa aaagacagta aaaatatatt agaattttat
    13921 aatgacagta cattagaatt taacagtaaa gattttattg ctgaagatat aaatgtattt
    13981 atgaaagatg atattaatac tataacagga aaatactatg ttgataataa tactgataaa
    14041 agtatagatt tctctatttc tttagttagt aaaaatcaag taaaagtaaa tggattatat
    14101 ttaaatgaat ccgtatactc atcttacctt gattttgtga aaaattcaga tggacaccat
    14161 aatacttcta attttatgaa tttatttttg gacaatataa gtttctggaa attgtttggg
    14221 tttgaaaata taaattttgt aatcgataaa tactttaccc ttgttggtaa aactaatctt
    14281 ggatatgtag aatttatttg tgacaataat aaaaatatag atatatattt tggtgaatgg
    14341 aaaacatcgt catctaaaag cactatattt agcggaaatg gtagaaatgt tgtagtagag
    14401 cctatatata atcctgatac gggtgaagat atatctactt cactagattt ttcctatgaa
    14461 cctctctatg gaatagatag atatatcaat aaagtattga tagcacctga tttatataca
    14521 agtttaataa atattaatac caattattat tcaaatgagt actaccctga gattatagtt
    14581 cttaacccaa atacattcca caaaaaagta aatataaatt tagatagttc ttcttttgag
    14641 tataaatggt ctacagaagg aagtgacttt attttagtta gatacttaga agaaagtaat
    14701 aaaaaaatat tacaaaaaat aagaatcaaa ggtatcttat ctaatactca atcatttaat
    14761 aaaatgagta tagattttaa agatattaaa aaactatcat taggatatat aatgagtaat
    14821 tttaaatcat ttaattctga aaatgaatta gatagagatc atttaggatt taaaataata
    14881 gataataaaa cttattacta tgatgaagat agtaaattag ttaaaggatt aatcaatata
    14941 aataattcat tattctattt tgatcctata gaatttaact tagtaactgg atggcaaact
    15001 atcaatggta aaaaatatta ttttgatata aatactggag cagctttaac tagttataaa
    15061 attattaatg gtaaacactt ttattttaat aatgatggtg tgatgcagtt gggagtattt
    15121 aaaggacctg atggatttga atattttgca cctgccaata ctcaaaataa taacatagaa
    15181 ggtcaggcta tagtttatca aagtaaattc ttaactttga atggcaaaaa atattatttt
    15241 gataatgact caaaagcagt cactggatgg agaattatta acaatgagaa atattacttt
    15301 aatcctaata atgctattgc tgcagtcgga ttgcaagtaa ttgacaataa taagtattat
    15361 ttcaatcctg acactgctat catctcaaaa ggttggcaga ctgttaatgg tagtagatac
    15421 tactttgata ctgataccgc tattgccttt aatggttata aaactattga tggtaaacac
    15481 ttttattttg atagtgattg tgtagtgaaa ataggtgtgt ttagtacctc taatggattt
    15541 gaatattttg cacctgctaa tacttataat aataacatag aaggtcaggc tatagtttat
    15601 caaagtaaat tcttaacttt gaatggtaaa aaatattact ttgataataa ctcaaaagca
    15661 gttaccggat ggcaaactat tgatagtaaa aaatattact ttaatactaa cactgctgaa
    15721 gcagctactg gatggcaaac tattgatggt aaaaaatatt actttaatac taacactgct
    15781 gaagcagcta ctggatggca aactattgat ggtaaaaaat attactttaa tactaacact
    15841 gctatagctt caactggtta tacaattatt aatggtaaac atttttattt taatactgat
    15901 ggtattatgc agataggagt gtttaaagga cctaatggat ttgaatattt tgcacctgct
    15961 aatacggatg ctaacaacat agaaggtcaa gctatacttt accaaaatga attcttaact
    16021 ttgaatggta aaaaatatta ctttggtagt gactcaaaag cagttactgg atggagaatt
    16081 attaacaata agaaatatta ctttaatcct aataatgcta ttgctgcaat tcatctatgc
    16141 actataaata atgacaagta ttactttagt tatgatggaa ttcttcaaaa tggatatatt
    16201 actattgaaa gaaataattt ctattttgat gctaataatg aatctaaaat ggtaacagga
    16261 gtatttaaag gacctaatgg atttgagtat tttgcacctg ctaatactca caataataac
    16321 atagaaggtc aggctatagt ttaccagaac aaattcttaa ctttgaatgg caaaaaatat
    16381 tattttgata atgactcaaa agcagttact ggatggcaaa ccattgatgg taaaaaatat
    16441 tactttaatc ttaacactgc tgaagcagct actggatggc aaactattga tggtaaaaaa
    16501 tattacttta atcttaacac tgctgaagca gctactggat ggcaaactat tgatggtaaa
    16561 aaatattact ttaatactaa cactttcata gcctcaactg gttatacaag tattaatggt
    16621 aaacattttt attttaatac tgatggtatt atgcagatag gagtgtttaa aggacctaat
    16681 ggatttgaat actttgcacc tgctaatact cataataata acatagaagg tcaagctata
    16741 ctttaccaaa ataaattctt aactttgaat ggtaaaaaat attactttgg tagtgactca
    16801 aaagcagtta ccggattgcg aactattgat ggtaaaaaat attactttaa tactaacact
    16861 gctgttgcag ttactggatg gcaaactatt aatggtaaaa aatactactt taatactaac
    16921 acttctatag cttcaactgg ttatacaatt attagtggta aacattttta ttttaatact
    16981 gatggtatta tgcagatagg agtgtttaaa ggacctgatg gatttgaata ctttgcacct
    17041 gctaatacag atgctaacaa tatagaaggt caagctatac gttatcaaaa tagattccta
    17101 tatttacatg acaatatata ttattttggt aataattcaa aagcggctac tggttgggta
    17161 actattgatg gtaatagata ttacttcgag cctaatacag ctatgggtgc gaatggttat
    17221 aaaactattg ataataaaaa tttttacttt agaaatggtt tacctcagat aggggtgttt
    17281 aaagggtcta atggatttga atactttgca cctgctaata cggatgctaa caatatagaa
    17341 ggtcaagcta tacgttatca aaatagattc ctacatttac ttggaaaaat atattacttt
    17401 ggtaataatt caaaagcagt tactggatgg caaactatta atggtaaagt atattacttt
    17461 atgcctgata ctgctatggc tgcagctggt ggactttttg agattgatgg tgttatatat
    17521 ttctttggtg ttgatggagt aaaagcccct gggatatatg gctaaaatat atgtttgata
    17581 aaaaattatt cctgtgctac taagaaatta tttttatata ataaatattg agatttaatt
    17641 aaaagtcatg tgttattgta atacatgact tttagttaaa atttttctat catttaataa
    17701 tctattattc ttgactattt tataataaaa ttcatatatg gaaatattaa tactaaataa
    17761 ttaatagttg ataaaaaata gataatatgc taaaagcaaa aactaattta gagccttgta
    17821 actgtttatt tgcaattata aaaacatctt taaacatatt gactataata taaaatatta
    17881 actataatac aaaacaatat taattaattt tctctacagc tatccctggt atagttatat
    17941 ttccacccat agttgattca taagttatag ttccagcact tatacctctt atagttatgt
    18001 aatcatcctc taatactctt gaaggagtta ttgatttttt ataactacat agtacaacct
    18061 tatcataatt tccagacaca gctaatctta tttgcacctc atcaccatct tcaataactt
    18121 gaataacctt accttcaaat tttacctttt tgtacttata atcatcaggt gttctagcta
    18181 attggtcata agtaatacca gtatcatatc ctttcttctc ctcttcttct tttttgcgtt
    18241 gttcttcagc ctttttagct tcttcagctt ttttagcttc ttcagcttta cgttgatttt
    18301 cagcttcaat agctttcttt tcgtcgtctt tcattttgaa ccatggttca gcatcagaca
    18361 atttgctatt taaagtttct atttctgttt tttgagaatc tataactgat gtttggttag
    18421 aaatgacctc ctcatggtct tcagaacaag ctggtgagga tatattgcca aaaaacacgc
    18481 ctaaaataaa tgccagtaga gcaataccct ttgtgctctt aaagaattta attattttct
    18541 tagagcttcc ttttccttca ttactaaatt cgttaccatc atttttttta gaaaacataa
    18601 tacaatctcc cttttattag atatatttta ttttaaaagt taaaaactta aaataactag
    18661 ttgactaaaa attatatatt catattttcc taaaatatat ttcccctaag cataatttta
    18721 caaaataaag taagaagatt caatatattt tgaaaaaata agataaaaat gtcagattat
    18781 aatataattt tcttgaaggt gaattttata tattaaatta aacataaagt attttatttg
    18841 tataaaacta tattatgatg taattaagtg actcagtgat ttagaggtgg taaaatatat
    18901 atatatgaaa gagcataaat aaattgatat aataaaaaat taaatattaa atattaacta
    18961 taataaaaaa atatctggta ataggtataa tataaaaaga atataccaga aagaaggtga
    19021 agtatgggag aactacaaaa aattccaggg gtagggaaag caacagaaaa atctttaatc
    19081 atgttaggat atacaactat taaatcactt aaagatgcaa acccagcaca aatgtatgaa
    19141 aaggaatgtt taatacgtgg acagcacata gacagatgtc agttatatgt atacagatgt
    19201 gcagtatatt ttgcatcaac tgaaaatcca gaaccagaaa aattaaagtg gtggtattgg
    19261 aaagattaaa aaatcaaaaa agttagacat aaaaaagagt tgaatatccg ttttaaataa
    19321 taaaaactaa tactcaactc ttttttagtc gtaaatttta tgtaaatcta tttgtatggc
    19381 taaatatacc catcaataaa tgtataaata taccaatcaa caaatgacta aacatactac
    19441 ctaacaaagg attaaataaa ttacttaaca aagcattcta aaacaattaa ttagaaactg
    19501 tttcttcaag ccattttcta cattgctcaa tatttaccat agggtcaaaa ccttggtctt
    19561 ttcccttatt taaaagcata tcacaaggga aagtatcaca ttcaccacaa tgattaagtt
    19621 ccttactttc acagcaagtt ttaaccttac attctccacc ccaaaatggt ttttccatag
    19681 ttgggcaacc agtgcaattt acttgttctt tttttgtaca actgtcacaa cagacaccac
    19741 atcttgattc aaacatgttc aaacatcctt tccattattt aaaaatatta taaaatgatt
    19801 ttagatgaat acaaaagtgc aaatagttga ttttaggtca tctaaatgtt aaacataaaa
    19861 ttattagtac tggtaaattt ataaaaacta ttccaaaaat ctttttgaat atttcaaaac
    19921 acaataaatt acttcaaatc cctttgaata tattttacag cattatagat tgctttaaat
    19981 ctctttgaat attctacaag actatagatt agtttaaatc cctttgaata tattttacaa
    20041 cattatagat tgttttaaat ctctttgaat attctacaag actatagatt agtttaaatc
    20101 cctttgaata tttcaaaaca ccatagatta ctttaaatcc ctttgaatat tctataacac
    20161 tataaattac ttttaacttt tatataacca taaagttttt atctggcact ttaaatggag
    20221 ttttatatca aatttgcctt ccatcgaata accaaactta atttaattac acattccaag
    20281 agtcaaatat tcattcaata tatttgataa ttctatgtta tagctataat taaatataga
    20341 ttattaaagt taaatattta tttaatatat tgaatgattt tttacctata tttaattaag
    20401 tttcattata taatataaaa attgtttttg cattaagttt taatataata cataataatt
    20461 ttaaataata acattattat atatttttta attttaggag tatatctatt atatagcgag
    20521 tagataaaac atataaaatt caaataaaag atatatattt ttaaataaaa tggatataga
    20581 tttcaactaa aaagaatata aatttcaaac cccaaaatat ctagcattta ccattaagaa
    20641 ataacatcat tctttctaaa atttctattg gcaatttcag aaaatactat agtagtaata
    20701 aatgcaacac atattgtaac tatagtgtca ttaacattta aagcagattg ctttataacc
    20761 cccatagcac tacctaacat agaataaggg aaaaatatac caacagcagg ttttgctact
    20821 attaatccca taccaaatag agaaaggcaa agactaatac caataggagt tgcaaaactt
    20881 ctaatcttta tagacatgta taattgtata gaagctattg aaatagaaat aatccaacct
    20941 ttagcaatcc aaccagtcaa ttctttaggt acactaccag aaaaaccaaa catatttcct
    21001 gcaactatat aaaagataac aaagaaaact tgtgtaatag ctgtaagtat tgaaactact
    21061 gtaagtttag ataaaaagat attttttaaa ttaactggca gtgtcattac attattccaa
    21121 ttatgattca tatgttcaag cctacaaata tatgcacaaa agattgcgat taagatagga
    21181 aagaaaaatt ccccataaaa aagactaact tgagtccata agctgtacca ttcttttttg
    21241 agtatgcctt gatttagata aaaattacca gaaccaatca acacacttat aagtggcaaa
    21301 gctaataata cataccatat aaaagaattt tttaacttta gaatttctcc caaaactgac
    21361 ttccttaaca tttaaatccc tcctatactt ctttttttaa taaatgattt cttccaatat
    21421 aataaattag cattccaatt aagaaaacta aaatcgtaat agaaaaattc atatcaattc
    21481 tatagacaga tgaacctaaa acattatcat aagcataact taaaggtgat aactctaggt
    21541 aataagacca tataaacaat ctacgaatac cttgataaaa caaacctgat gtcaaaccta
    21601 taaaactacc aatcatgcca aatgtaattg caatcatttg atttggaatt acagttgcaa
    21661 tccataggtg tagtgcaatg atagcaatac ttacaagaat tgttcctaat gtgtatttta
    21721 aaagtaaaga tacagaaatt gactcaataa cccctctaaa atgtccaaac aacacaatag
    21781 ataacacttg catcaataca ggtatagata ccaaaatagc agaacataaa aatttagata
    21841 aataaatact atttaaagat gtcacagaag attttaaaag cttccatgta tctcctttat
    21901 gttctatatc gcttatacgt gatgtaatta ttgatattaa gataggaaag aatagaccat
    21961 ttaaacttgc aaaactcata aacatatagg aatattcaaa tccacctaac atatctggat
    22021 tacgtgtaat agctctattt gaatttatga tacaccacat tatttcaaca gctacaaata
    22081 aaaaggtcat cagaataatc ttctttcttt taagtttata aaattctaga ccaaggtatt
    22141 tcattataaa gtcaccgcct taccagtaag ttctaagaat atatcttcca agcttttttt
    22201 atgttcttct attctaaata catctatatt tgaatggaca agcataccat ttattttagc
    22261 cacatctgag tcttttaaat tttcaatagt caagtaccca tcttgtataa gtgacatata
    22321 tcctttagta tttaatagtt tttgtgcaga tacaacattc ttagttttga tagcaatctg
    22381 actttgacct ctattatgaa gttcttttat gctatcttga aaaaccagtt cgccatgatt
    22441 tattattcct attgatgtgg caatttggtc aatttcactt aaaagatggc tagagattag
    22501 aacagtcatc ccgtattttt ctggtagaga ttttattaat tctctaattt cctcaatccc
    22561 tgctgggtcg agtccatttg taggttcatc aagtattaat aatttgggaa acttcattat
    22621 tgccatagca ataccaagac gttgcttcat acctaaagaa tattgactaa cttttttatt
    22681 tttttgattt tctaacctta caatttttaa tgcttcattt acattttttt taggtaaatc
    22741 taagagtttt tgcattatgg tcatgttttc aagccctgta agatgaccat agtatgatgg
    22801 agattctatc aaagaaccta tatcttttaa aattgatatt ctattttttt catttaactc
    22861 tttacctaaa atattaatat ttccttgtgt gggtttagca agtccaagaa gcattttaag
    22921 agtggtagat tttccagctc cattaggacc caaaaaacca tatacagctc cttgtggaac
    22981 tcttaggtct atatccttta ctctaaatat tttattgtat tcctttgaaa gtctttgtgt
    23041 tctaattatc atttccatat gtttcatccc cttttttaat ctgtgcttat tgattctttt
    23101 aacttatatc agtataataa cttggttaca tttcaattag ctgaaattta ccttacaata
    23161 accttaaaag tctatttagg caaagttgtg aaaatgggta tatggtatac taaaggaggg
    23221 tgatgattat ggagtcaata aaagataaaa aaatacttgt ggttgatgac cacaaggaat
    23281 tattaaaaat gatagatgaa atcctgagaa aagaggggtt tagtagagta tttttagcat
    23341 caagttatga ggaagctgtt agggtattta gaaatgtaaa gccagattgt gcaattttag
    23401 atgttgtatt gccagatgga gatggttttt ctattatgag aaaaattaga gagacatcta
    23461 aaataccagt gatttttctc tctgcaagag gtgaagatga agatagattg attggtttgg
    23521 gcttaggggc tgacgattat atagtaaagc catttttacc aaaggaactt actttaaggc
    23581 ttgtgggtat attaaatcgt gtatatgtgc ctatagaaga agaggagttg ccagtattta
    23641 aactgggaga ttctgttgtt gtgaatttaa atagtgcatg tgttgagaaa gatgggcaag
    23701 agatttcttt aacagctaaa gagcattcgt tgcttttaaa gttgtatgaa aataaaggga
    23761 gaattgttac taatgattca ctatgtcaag ccatttgggg agatgatatg tatggatatg
    23821 aaaataccct tatggttcat gttagaaggg ttagagagaa gatagaaaaa actccatcta
    23881 cacctaaaca tcttattaca gtaagaggtc ttggatataa gttgatgatt aattaatttt
    23941 agatattaga ataaaagaaa tcaagaggag tgatttaatt ttggatagtg taaagtacat
    24001 attgaggcga tttataggtt caagtatctt gatttcatta ctttttattg tattaaatat
    24061 agcaggtttt cttctgtttt catatatgct atttgtatct aaatactctg ataatttaga
    24121 tacaagtgat agcagagaaa taaaatcaaa cttgattatg attgaagata atttgatttt
    24181 aagaaatgga aagtttattt tagatgattc tagtaaggaa gtactacata aaaataaagt
    24241 ttgggcaatg ttaattgata acaatggaga tagaatatgg ggatttgatt taccaaaaga
    24301 aattccaagt cattatactt tgacagatgt agcaaagttt tcaaggttct ttttaaagga
    24361 ctatcctgtg tatgtatggg aacatccaaa tggaatatta gtaacaggtt atccaaaaga
    24421 caagtacact aagtttaacc ttacttatac ggttaaggaa atagaacaat ttcctatgtt
    24481 aataataggt atgtttttgg ttaatgcaat agttactttt ttaatagctc tattcatagg
    24541 tttaaaaatg gtgaaatcta taaaaccaat tattactggc ataaagctta tgtcaaaagg
    24601 agaaccagta cttttacaag aaaaaggaat actaagtgat atttcaaaat ctattaatac
    24661 tgtatctaaa gagttgcaaa tgaaagatga aaaacttagg aagaaagagg aagctaggtc
    24721 taactggatt gcaggaatat ctcatgatat aagaactcca ctttcaatga taattggata
    24781 tgctggagaa cttgaagaaa gcagtagcct ttcaaataga gaacaagagc aagtgtctat
    24841 tatatgcaat caagggatta aaatcagaga attagtaaat gacctaaatt tagtgtctaa
    24901 acttgaatat aatatgcaag cattgaattg tgataagatt agagtttctg cgtttttgag
    24961 agagcttatt tctgagttta taaataataa tttggataat gacttttacg ttgaatttga
    25021 tatactaaat gaagatatta ttatagatgc agataaaaaa ttattaaaaa gggctattag
    25081 taatttaata caaaatagta taactcataa ccaacaagga tgtaatataa gggttacctc
    25141 taagtctgat ttagattttt gctatataat tgttgaagat gatggaaaag gtatgagtca
    25201 agaaagaatt aatagtttat taaagagcca aaatggacta agtgaggcat atgccaaagg
    25261 tcaaaatcat ggtctaggta ttttgatagt atctggcatt attaatgcac atagaggtaa
    25321 attagatatt acgagcattg atagtcaggg actaaaaaca atactaaaat tacctctaat
    25381 taagtgatat tttataaaat aataacagat aagaatgaag aatgaaaata ttttgaaaat
    25441 aattttattc tttattgaca aattaactct attagagtag aataaggata aattcttttc
    25501 ttgtcaagtt ttattaaagt aaagagtaac ttgtgcttta tgcgcttatg gctgagttac
    25561 tcatggtatc aaaattttca tagaaataat attttggaat tattgtaagg ttattaaatt
    25621 ctttagataa ttccattttt tttatttttt agttaatatt taattttatt attgacaaaa
    25681 aaattctact aaaatagaat tatggtatag tgttttttaa ttttaagaaa aaatataatg
    25741 acatcctaaa aaagtttt
//
LOCUS       DAEPID010000053        25451 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.053, whole genome shotgun sequence.
ACCESSION   DAEPID010000053 DAEPID010000000
VERSION     DAEPID010000053.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 25451)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 25451)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..25451
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.053"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            complement(230..2872)
                     /gene="adhE"
                     /locus_tag="KR257_002497"
                     /gene_synonym="adhC"
     CDS             complement(230..2872)
                     /gene="adhE"
                     /locus_tag="KR257_002497"
                     /gene_synonym="adhC"
                     /EC_number="1.1.1.1"
                     /EC_number="1.2.1.10"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892607.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional acetaldehyde-CoA/alcohol
                     dehydrogenase"
                     /protein_id="HBH0031180.1"
                     /translation="MEKKEKVVEKSNVEVCSPEIVNSVETLRMRLEEIRLAQKEFATF
                     TQEQVDKIFLAASTAANQQRIPLAKMAVEETGMGIVEDKVIKNHFASEYIYNAYKDTK
                     TCGVIEKDEAFGFTRIAEPVGVLSAVIPTTNPTSTAIFKSLIALKTRNGIIFSPHPRA
                     KNCTIEAARVVHDAAVKAGAPKGLIGWVDVPSIELTNVVMAEADLILATGGPGMVKSA
                     YSSGKPAVGVGPGNVPAIIDESADIKMAVSSILVSKSFDNGMICASEQAVIVPEKIYE
                     EVKKEFKYRGAHFLNKEETEKVGKVVIIDGSLNARIVGQPAHVIAKMADVEVPKTARI
                     IIGEVESVELNEPFAHEKLSPVLAMYKSKSFEDAVAKAEKLVADGGYGHTSSLYADSI
                     NHPERVEKFVNAMKTCRVLVNTPSSQGGIGDLYNFKLAPSLTLGCGSWGGNSVSENVG
                     VKHLLNIKTVAERRENMLWFRAPEKVYFKKGCLGVAAREFKDVMDKKKAFIVTDSFLY
                     NNGYTKKLTDLLDEMGIKHTTFFDVAPDPTLACAREGAKAMADFQPDLIIAVGGGSAM
                     DAGKIMWVMYEHPEVDFQDLAMRFMDIRKRVYVFPKMGEKAYFAAIPTSAGTGSEVTP
                     FAVITDQDSGVKYPLADYELMPNMAIIDADMMMEMPPRLTAASGVDALTHALEAYVSM
                     LRTEPADGLALQAGKIIFEYLPRAYKNGKNDKEAREKMAMASTMAGMSFANAFLGICH
                     SLAHKLGAFHHVQHGVANALLINEVIKFNCAEAPNKMGAFSQYRYPDCIQRYAEFASF
                     AGIKGSTDQEKVDNLIKAIDELKAKVGLPKTIKEAGVEESKFLERLDAMVEQAFDDQC
                     TGANPRYPLMSELKEIYLKVYYGK"
     gene            3750..5348
                     /locus_tag="KR257_002498"
     CDS             3750..5348
                     /locus_tag="KR257_002498"
                     /EC_number="3.6.1.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003427831.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="putative manganese-dependent inorganic
                     diphosphatase"
                     /protein_id="HBH0031181.1"
                     /translation="MSLLVFGHKNPDTDSICSAISLAHLKNKLGIKATAYALGDIRKE
                     AKYALDYFKVDAPEILDNVRIQVRDLNYDKVVPLTPTSSILEAYNLMDEKNVKTLPVT
                     YDDGTFAGIITMKEIAKNLLHQHFTTIHTSLSNICKNLNGTILVDCGEDIKGRVVTLS
                     FGMETLIETLKEGDIAIVGDRYDSIEYAIDTKVKLLILTNHTEISKDLLALAKINGVS
                     VVSVESDNYKTSNVINQCSFLDSIEATENLITFKEDDYMDEIKEIMLETNFRSYPILD
                     DDNKFLGLVSKGHLLNPSKKNVVLVDHNEYAQSADGIEQANIVEIIDHHKLGGISTDV
                     PMSFRVMPVGCNSTIIYQMYKENNVEIPYEIAGLLLSAILSDTLLFKSPTTTDMDKKA
                     CEELSKIAKVDMEKYAMDMFKCGTSLDEYTIEEIVNMDFKEFNMSGHRVGIGQVFTLD
                     IDSIFAKKDEFLSYINSTDYDKLILSVTDIIKEGSYLIYKAEDSLIANAFGVEGVQGT
                     FAPGVVSRKKQLVPNLTTAIKNFK"
     gene            complement(5583..7664)
                     /gene="bclA1"
                     /locus_tag="KR257_002499"
     CDS             complement(5583..7664)
                     /gene="bclA1"
                     /locus_tag="KR257_002499"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860734.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="collagen-like exosporium glycoprotein BclA1"
                     /protein_id="HBH0031182.1"
                     /translation="MRNIILYLNDDTFISKKYPDKNFSNLDYCLIGSKCSNSFVKEKL
                     ITFFKVRIPDILKDKSILKAELFIHIDSNKNHIFKEKVDIEIKRISEYYNLRTITWND
                     RVSMENIRGYLPIGISDTSNYICLNITGTIKAWAMNKYPNYGLALSLNYPYQILEFTS
                     SRGCNKPYILVTFEDRIIDNCYPKCECLPIRITGPMGPRGATGSTGPTGVTGPTGSTG
                     ATGSIGPTGPTGNTGATGSIGPTGVTGPTGSTGATGSIGPTGVTGPTGNTGVTGSIGP
                     TGATGPTGVTGEIGPTGVTGPTGVTGSIGPTGATGPTGATGVTGEIGPTGATGPTGNT
                     GVTGATGPTGNTGVTGVTGATGPTGATGVTGEIGPTGATGPTGEIGPTGATGPTGATG
                     VTGEIGPTGVTGPTGEIGPTGATGPTGVTGSIGPTGATGVTGEIGPTGPTGVTGSIGP
                     TGATGPTGNTGVTGVTGPTGATGPTGVTGEIGPTGATGPTGVTGEIGPTGATGPTGPT
                     GNTGATGSIGPTGVTGPTGATGATGVTGPTGPTGATGNSSQPVANFLVNAPSPQTLNN
                     GDAITGWQTIIGNSSSITVDANGTFTVQENGVYYISVSVALQPGSSSINQYSFAILFP
                     ILGGKDLAGLTTEPGGGGVLSGYFAGFLFGGTTFTINNFSSTTVGIRNGQSAGTAATL
                     TIFRIADTVMT"
     gene            complement(8342..8866)
                     /locus_tag="KR257_002500"
     CDS             complement(8342..8866)
                     /locus_tag="KR257_002500"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434191.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptidylprolyl isomerase"
                     /protein_id="HBH0031183.1"
                     /translation="MENKNPIVTIEMENGKEIKIELYPNIAPNTVKNFVSLVNEGYYN
                     GIIFHRVIPGFMIQGGCPNGTGMGGPGHSIKGEFSGNGFTNNLKHERGVISMARTMAP
                     NSAGSQFFIMHKNSPHLDGQYAGFGRVIEGMDTVDEIASVRTDSADKPQTPQIMKSVT
                     VETFGIDYSDVEKN"
     gene            complement(8931..9683)
                     /locus_tag="KR257_002501"
     CDS             complement(8931..9683)
                     /locus_tag="KR257_002501"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003417271.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="patatin-like phospholipase family protein"
                     /protein_id="HBH0031184.1"
                     /translation="MKLGLCLEGGGAKGAYQAGVVKALYDGGINKFYSISGTSIGAIN
                     GYYLYTGNVDNLEKMWTNIKDIQNGNVKIVNNTVDNSPAIDNLRELDDSNIEEMNFYV
                     NYVEVDNKVVSEKIVDVSKMPRNEAIISISYSGLLPSNPNATLGFKEQFVKDVQEGIY
                     DGFKLDGGLIRSALIEPLIGDNVDKIILISTKYNYELPEDIKKVYDEDKIIVVRPNTQ
                     FAPKDTLNFDDEFCKTIYQEGYEIGKNILDRL"
     gene            complement(9714..11012)
                     /locus_tag="KR257_002502"
     CDS             complement(9714..11012)
                     /locus_tag="KR257_002502"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888187.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="M18 family aminopeptidase"
                     /protein_id="HBH0031185.1"
                     /translation="MDSINFAKNLIDFIYDSPSSFHAVKSTKEILDKNGFEELVLNQR
                     WNLRVGGKYYVTKNLSAIVAFVVNSEDIERDGFRIIGSHSDSPTFSIKPNAEIEAEKS
                     YLKLNTECYGGAILSTWLDRPLGIAGRVVLKGDSILKPNERLIDFKRPICIIPNLAIH
                     LNRSINDGHSYNKQKDMLPLVGMLNDTLEKDNFLIKQIASNLDVNMDDIIDFDLFLYE
                     FEKGSLIGANDEFISIGRQDNLAMVHASLNALVNTKGQHGVNVMAVFDNEEVGSSTKQ
                     GADSNMLLNILERICISMGKDREGFFESIYSSFMISSDLAHAIHPNIPEKHDPTNKPI
                     MGKGPVIKINASQAYTSDGYSIAIYKNICREANVEYQEFVNRSDERGGSTIGPISSTH
                     IDIPSVDVGSPILAMHSIRELGNVEDHYSIYKTFSKFFEI"
     gene            complement(11029..13293)
                     /locus_tag="KR257_002503"
     CDS             complement(11029..13293)
                     /locus_tag="KR257_002503"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888186.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3553 domain-containing protein"
                     /protein_id="HBH0031186.1"
                     /translation="MNLDTLNPAQREAVEKTEGPVLILAGAGSGKTKVLTTRIAYLIE
                     DKGVQAPNILAITFTNKAANEMRERVEQNIGPETKDMWISTFHSCCVRILRKDINKIG
                     YNRSFVIYDSADQVTLVKDCLKELNLSDKVFEPKAVISAISGAKDKLYTPKQFKDINM
                     ADNRMVKIADIYALYQDRLKRNSALDFDDLILKTVELFKANDEVLAYYRSRFRYIMVD
                     EYQDTSKAQYELIKLLAREHQNICVVGDDDQSIYGWRGADIRNILEFEKDYDNVHVVK
                     LEQNYRSTQVILDAANKVISNNIERKRKKLWSEKKEGELIKIQLTGSEIEEADFIADS
                     IAQIARKENRPYKDFAVLYRANAQARPVEDALNRSQIPYNIYGGTKFYERKEIKDLLA
                     YLRVIQNPQDDISIKRIINVPRRGIGLRTIEKIEDRANLKQESIYSVLIDIETNSDIS
                     TKARASISGFVDIIGTLRTIKEVYPVSKLIEKVLDTTGYMDELVEIRNKNEKDLTGKG
                     EEAQDRIDNLREFISIALEFESSNDDTYENKDLETFLTSIALTSESNDEEDNDRVSLM
                     TIHTSKGLEFPVVFLTGMEEGLFPISRAIKSMSDSQIEEERRLCYVGITRAKEELYMS
                     LTEKRTLYGKTNVAIASRFMEELPEECIERLYKVKKELSYSKASYNMLDKYTKKYMST
                     ISKSKVADKVNATIKDSNKETNPDDIKLGSKVHHPKFGVGTVVSIIGTDVTIAFDQQG
                     IKKINKEYTTLNIL"
     gene            complement(13548..14366)
                     /locus_tag="KR257_002504"
     CDS             complement(13548..14366)
                     /locus_tag="KR257_002504"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009904855.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="energy-coupling factor ABC transporter
                     ATP-binding protein"
                     /protein_id="HBH0031187.1"
                     /translation="MFKINNLTYQYEKNTNALLNINMDFSKGNVIGIIGSNGSGKSTL
                     FMNLMGILKPTSGEILFKEEKLKYDKRSLYNLRKNVGIVFQDPEKQIFYSKVYDDIAF
                     AMRNIGMDEKTIKERINKALVAVNGIDFIDRPVHFLSYGQKKRVAIASVIAMENEIVL
                     LDEPTAGLDPVSTRSIVDIIKGLNKNNIKIVISSHDMNLMYEICDYIYVLDKGILIDE
                     GKAENVFINENNIIQAGLESPWLVKVHRNMNLPLFKKEEDLYKYWKERELNTNK"
     gene            complement(14359..15057)
                     /gene="cbiQ"
                     /locus_tag="KR257_002505"
     CDS             complement(14359..15057)
                     /gene="cbiQ"
                     /locus_tag="KR257_002505"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003417243.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cobalt ECF transporter T component CbiQ"
                     /protein_id="HBH0031188.1"
                     /translation="MLIIDKYAYTNRLSKVNPNKKVAIGVIFLIASMVIQNIFILSGI
                     MILMSILVVCVAGIDLKNYLKLLRIPMYFLFLSIGITLVNISFNKADLLYSFEFFSFN
                     VGISKASIDMSIHVLFRAMSCLTCVYFCILTTPFNQLIFFFKKLHLPDTFVELSMLIY
                     RFIFIFLEEFSEIYKSQELRFGYINLKTSYKSLGILGSMLYKRLMTRYDDMCISLDIK
                     LYDGKFHIVGDNDV"
     gene            complement(15060..15338)
                     /locus_tag="KR257_002506"
     CDS             complement(15060..15338)
                     /locus_tag="KR257_002506"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895390.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="energy-coupling factor ABC transporter
                     substrate-binding protein"
                     /protein_id="HBH0031189.1"
                     /translation="MSAKTKTNILLLLLVVALIIFPLLVNSGAEYGGADGQAESEITK
                     INPNYKPWFSSPYEPPSGEIESLLFSAQAALGAGVIGYILGLQKGKRS"
     gene            complement(15328..16080)
                     /locus_tag="KR257_002507"
     CDS             complement(15328..16080)
                     /locus_tag="KR257_002507"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006440549.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="energy-coupling factor ABC transporter permease"
                     /protein_id="HBH0031190.1"
                     /translation="MKQNIKLGVIAALMLIILTPVTSNAMHIMEGYLPVKWSIAWGVI
                     FIPFFLFGLKSIGKIVKQDPKKKVLLALCGAFVFVLSALKIPSVTGSCSHPTGVGLGA
                     IMFGPSVMFVLGTIVLIFQALLLAHGGITTLGANAFSMAIIGPIVSFLIFKALKKKDG
                     NNAIPVFLAAAIGDLATYTITSIQLALAFPDPSGGVMASAIKFLGIFFMTQIPIAIAE
                     GILTVIVYNLITENGEKSILENNDKGVKANEC"
     regulatory      complement(16262..16454)
                     /regulatory_class="riboswitch"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00174"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="cobalamin riboswitch; Derived by automated
                     computational analysis using gene prediction method:
                     cmsearch."
                     /bound_moiety="adenosylcobalamin"
                     /db_xref="RFAM:RF00174"
     gene            complement(16586..18358)
                     /locus_tag="KR257_002508"
     CDS             complement(16586..18358)
                     /locus_tag="KR257_002508"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003427150.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nitric oxide reductase activation-like protein"
                     /protein_id="HBH0031191.1"
                     /translation="MKWIYDDYEFENRANNLSWTIAGDYNESIDISEKDYSSKEIGLY
                     FAIIAGARRKYVDWDIVKKYLTNRIRKGYNKDIILGLIQVILNTIVEEKVIKDRPGIE
                     DIRRNAYKDIVSRFTKIHNDNIMDKIKYTFVLYSMDKHPALDSMTRRIVNDIRNIDTN
                     QDIMEILKALDVIYLTYFEYILNGEENSLIDENNVESVEVNFDTFADFMYEELYSDEE
                     ENIIESDIDSISSSMLVEGVGDFDDSKCSNSADRVIYVDEDTANKIYSKIEHYYGKTY
                     LSKGEIKKIETQNCRNVHEGCRIHFTDGVLRSECNNVFQLKYVTRQKENNLGKFREHA
                     RMYRQQIKRLKESLSRILIEENAKSRVYSDCGTILANRAWRVGRSNNNKIFYKDIENE
                     KGKYVIDILLDASGSQSRNQGNVAIQAYIIANALTEVGIPNRVMGFSSFLDYTILKRF
                     KDYDDSIKNSENIFEYFCAGNNRDGLAIKSICSGLINRDEENKILIVLSDGRPNDVKI
                     GKSSERTLRGEKAYRGIVGLRDTANEVRKARKQNILVLGVFTGKESELEAERLIYGND
                     FIYSRDITRFSDVVSMYLKKIIRN"
     gene            complement(18372..19301)
                     /locus_tag="KR257_002509"
     CDS             complement(18372..19301)
                     /locus_tag="KR257_002509"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434205.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AAA family ATPase"
                     /protein_id="HBH0031192.1"
                     /translation="MDIIDNLRVQGVDEKLIEDVLYFRNYYGLEKDLEYRVTKSKTYF
                     YGKDILSMCIAAILEEENILLSGPKATGKNLLADNLGEIFNRPQWNTSFHINTDSSTL
                     IGTDTFIDNEVKLRRGSVYECAINGGFGVFDEINMAKNDAIVVVHSALDYRRIIDVPG
                     YERVNLHPATRFIGTMNYEYAGTKELNEALVSRFMVIDIPPIEEDKLMMILKNEFSDA
                     DEEKLIHFAGIFLDLQLKSQNGEISSKAIDLRGLMASLKTIRRGLKPTLAINMGLTGK
                     TFDVYEKEMVGDVIKTRIPNKWESIDVFPISHI"
     gene            19530..19718
                     /locus_tag="KR257_002510"
     CDS             19530..19718
                     /locus_tag="KR257_002510"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888180.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="HBH0031193.1"
                     /translation="MEYMSCPEVAKKWGISERRVQKLCEESRIPGVSKLGYMWLIPKN
                     AEKPVDGRTKRRKEVQYE"
     gene            19711..20412
                     /locus_tag="KR257_002511"
     CDS             19711..20412
                     /locus_tag="KR257_002511"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434208.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HBH0031194.1"
                     /translation="MNSVLIIDDDKELCALMKKCVEQENLSAITAHGGAEGLHLVDKN
                     RHTLSLVILDIMMPDIDGFQVLKKIRETSNIPVIMLTAKNDEDDKVSGLRLGADDYLT
                     KPFSINELMARVNSLIRRYTMLNPAFITDTDFIIINGMIIDKTNRIVSVNNIPVQLTS
                     KEFDLLAFLASNKGRVFTKKQIYTQVWEEEYAFDDSNIMSFISKLRKKIEPDPNHPFY
                     ILTVRGVGYRFNKEA"
     gene            20414..21337
                     /locus_tag="KR257_002512"
     CDS             20414..21337
                     /locus_tag="KR257_002512"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003427141.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HAMP domain-containing histidine kinase"
                     /protein_id="HBH0031195.1"
                     /translation="MNTSVYLLLILALSLIIIAYLVSVLLRVRIQLTLIKDALEDIKN
                     GNLNRRILTDENDITKQICYDINEIAINSQFQLIQQKQSEQAYKQLMTSLSHDVKTPL
                     ASLVGYLEAVESKIVVGEEKDEYIHVASNKAHYLKNFVENLFEWVKLDSKEQVFHFDI
                     FDLNELSRNIISDWIPVLESSHFEYEFDIPEIEYFLRIDANAYTRIINNLLQNIITHS
                     SGNKMTLRIFENKEQAQIIITDNGKGISSDNLPHIFERLYQCDHSRASKGNGLGLAIA
                     KELINAHKGNITANSTPGMGTEFTILLPKAL"
     gene            21494..22417
                     /locus_tag="KR257_002513"
     CDS             21494..22417
                     /locus_tag="KR257_002513"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019639192.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBH0031196.1"
                     /translation="MNDFVIETKQLTKIYGNQTVVDKVNLHVKKGRIYGLLGRNGAGK
                     TTIMKMILGLTSITYGEVDVFGENIKGREKQVYPRIGAIIETPGFYPNLTGTENLEIF
                     AKLRGTAAPNSVKRALEIVGLPYKNKKLFSKYSLGMKQRLGIANAILHDPELLVLDEP
                     TNGLDPIGIAEMRKFIRDLSVEHGKTILISSHILSEISLLADDIGIIDHGVLLEESSM
                     SELEKKNSKYILLQVSDIPKTSLILERQFNTKDYSVQDDYTLHLYNTNLDMGEINKAL
                     VMQNVTVISSQLCNDTLEDYFKKITGGEGIA"
     gene            22410..23147
                     /locus_tag="KR257_002514"
     CDS             22410..23147
                     /locus_tag="KR257_002514"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434216.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBH0031197.1"
                     /translation="MLKLIQTEFLKLRRRKLIWLMLLSALIMPFFALLYFNYFGKTGV
                     EPIKFYKWSAFGYTLWIILPVVLGIFCTMLIHEENQYDMLKQLWIVPISKMGYFFSKF
                     FVVLIYSICFMLITAVASVLFSVLSGYVVFSWASILYLLKKCLEIGVITAFVMLPILA
                     IATSQKGYILPICITLVYAFSGFVIMTINMYLHPLSSMGVIIMRNKDIPGLIFSQEIN
                     VPLAFLCICIWSIVSVLFANIALGRRK"
     gene            23158..23931
                     /locus_tag="KR257_002515"
     CDS             23158..23931
                     /locus_tag="KR257_002515"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434217.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBH0031198.1"
                     /translation="MWKLLWAECQKIRRSKIVWITVFASIMIAVIVFAGGQDVYNDPD
                     LHYGLKSVYDGSRYIDNAGWYMDAVQPWSTFFVLPAVIALLGSYIICREEEEDTIKSL
                     RLIPINETNLTIAKMIITFIFSILLYLLLFTITFLTESVLHFSDLSTKLVLSCMKEYF
                     LDGIGVFFAISPIIALVSRMKKGYWLALVFTEVYSIAGLFAGMSNVLQTFFPIAAIFN
                     ISGYYITTGEKIMGSIMSLLLCACLSAFILKGLKHNEKN"
     gene            complement(24472..25080)
                     /locus_tag="KR257_002516"
     CDS             complement(24472..25080)
                     /locus_tag="KR257_002516"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895382.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DedA family protein"
                     /protein_id="HBH0031199.1"
                     /translation="MSVINSFILQYGLISVFVLIMIEYACFPLPSEVVLPLCGAIAAR
                     NHFGFLTILILSIIAGILGSIFCYTVGNWGGKSIINKIIEICPKAKKGIFASQDYFNK
                     YSSISVCVCRLIPLCRTYISFIAGIAGQNIITFVISSIVGITIWNTSLISIGYIFSES
                     WVRIMSHYNDYKFLVLIIPISIIFIGFVIKSFIHKKHHKIRL"
     gene            complement(25258..25374)
                     /gene="rrf"
                     /locus_tag="KR257_002517"
     rRNA            complement(25258..25374)
                     /gene="rrf"
                     /locus_tag="KR257_002517"
                     /product="5S ribosomal RNA"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00001"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: cmsearch."
                     /db_xref="RFAM:RF00001"
BASE COUNT         8046 a         4439 c         3305 g         9661 t
ORIGIN      
        1 aaaattatat gtaataaaaa aattttccga ctaattttaa agttaattga ttaaatacac
       61 atattcgaaa ttaccattaa attactgact ttttatcatt tccatttaga atttaagtta
      121 taatctatta tttatagtta cttctacgtg tctctaataa aactctattt atattcaaat
      181 ctaataattt atatacaaac ccaatagaac ctatgttgca caatagatat tatttaccat
      241 aataaacttt tagatatatc tcttttaatt cactcatcaa tgggtatcta ggattagcac
      301 ctgtacattg gtcatcaaaa gcttgttcaa ccatagcatc caatctttct aagaatttag
      361 attcttctac tccagcctct tttatagtct taggaagacc tacttttgcc tttagttcat
      421 ctattgcttt tataagatta tctacttttt cttggtctgt acttccttta atacctgcaa
      481 aagaagcaaa ttcagcatat ctttgtatgc aatcaggata tctgtattgt gagaatgcac
      541 ccattttatt tggagcttct gcacaattga acttgattac ttcatttatt aataatgcat
      601 ttgcaacacc gtgttgaaca tggtggaatg cacctaattt atgtgctaaa gagtgacata
      661 ttcctaagaa ggcatttgca aaagacattc ctgccatagt agatgccatt gccatttttt
      721 ctcttgcttc tttatcattc tttccatttt tatatgcacg aggtaaatat tcaaatatta
      781 ttttacctgc ttgtagtgct agaccgtcag ctggttcagt tcttaacata gatacatatg
      841 cttctaatgc atgtgttaaa gcatcaacac ctgatgctgc tgttaatctt ggtggcatct
      901 ccatcatcat atcagcatca attatagcca tgtttggcat taattcataa tctgctaatg
      961 ggtactttac acctgaatct tggtcagtta taactgcaaa tggagttact tctgaaccag
     1021 ttcctgctga agttgggata gcagcaaaat acgctttttc acccatctta ggaaatacat
     1081 atactctttt tcttatatcc ataaatctca tagctaagtc ttggaaatct acttctggat
     1141 gctcatacat tacccacatt atcttaccag catccattgc acttcctcca cctacagcta
     1201 ttattaaatc tggttggaaa tcagccatag ctttagctcc ttctcttgca caagctaatg
     1261 ttgggtctgg agctacatca aagaatgtag tatgcttaat tcccatctca tctaataaat
     1321 cagttaattt cttagtatat ccattattat ataggaaaga atctgttact ataaatgctt
     1381 tctttttatc cataacatcc ttaaattctc ttgctgctac acctaaacat ccttttttga
     1441 aataaacctt ttctggtgct ctgaaccaaa gcatattctc tctcctttca gctactgtct
     1501 tgatattaag caaatgtttt actccaacgt tttcagatac tgagtttcca ccccaagaac
     1561 cacaaccaag agtaagagac ggtgccaatt taaagttata taaatcacct ataccacctt
     1621 gtgatgatgg agtattaact aatactctac aagtcttcat agcatttaca aacttttcta
     1681 ctctctctgg atgatttata gagtctgcat ataatgaaga tgtatgacca tagcctccat
     1741 ctgcaactaa tttttctgct ttagcaactg catcttcaaa acttttagac ttgtacattg
     1801 caagtacagg agaaagtttt tcatgtgcaa aaggttcatt taattcaaca gattctactt
     1861 caccaattat tattctagct gtttttggaa cttctacatc cgccattttg gctattacat
     1921 gtgctggttg tccaactatt ctggcattta atgaaccatc aattattact acttttccta
     1981 ctttttcagt ttcttcttta tttaggaaat gtgctccacg atatttaaat tcttttttaa
     2041 cttcttcata tattttttct ggtactatta cagcttgctc ggaagcacat atcataccat
     2101 tatcgaatga ttttgatact aagattgaac ttacagccat ttttatatct gcactctcat
     2161 ctattattgc aggtacattt ccaggcccaa ctccgacagc tggtttacct gaagagtatg
     2221 cagatttaac cattccaggt ccaccagtag ctaatataag gtctgcctct gccatgacaa
     2281 cattagttaa ttcaatcgaa ggaacatcta cccaacctat aagtcctttt ggtgctcctg
     2341 ccttaactgc tgcatcatgt acaactctag ctgcttctat agtacagttt ttagctcttg
     2401 gatgaggaga gaaaattata ccatttctag tttttagtgc tattagggat ttgaatattg
     2461 cagttgatgt aggattagtt gttggtataa ctgctgataa aacacctact ggctcagcaa
     2521 ttcttgtaaa accaaatgct tcatcttttt ctatgacacc acaagtttta gtatctttat
     2581 aagcattata gatatattct gaggcaaaat ggttttttat aaccttatct tcaacaatac
     2641 ccataccagt ctcttccact gccatttttg ctagaggtat tctttgttga ttagctgcag
     2701 ttgaagcagc taagaaaatc ttatctacct gttcttgcgt aaatgttgca aattcttttt
     2761 gtgccaatct aatttcttct aatctcattc ttaatgtttc aacactgttg acaatttcag
     2821 gactacatac ttcaacattt gatttttcta ctaccttttc ttttttctcc atactaaaaa
     2881 cctccctaaa ataattatgc atctctaatt tttattaatc ttaaatgcat catctatatt
     2941 tttaacttat acttaaaata attttataga tttcatctct ataccttaga ttttatttat
     3001 tttactctct taggtcaaga agtttttttc tgaatatttt gtcaatttat tttttaacaa
     3061 atatattatt ttttttactt ttactaaaat tttttatcta aatgagatat atttcatttg
     3121 aataatttac ttcgactaaa taaaatacta aaatgataat ttatatcttt catttttttt
     3181 acttattaaa ttttatatgt tatttgcatg ttatttgtat aagtagtaaa taaaattttt
     3241 gtcgtatttt tataaaataa cacttatttt tgacttgtat gcaatttttc tttttataac
     3301 aactgtatag ttttaaaaaa tatataaact aaaattattc taatctctat aagttatttt
     3361 taagtcaata tgtaataatt atgcttttca tatagataaa taatttttat attaagaccg
     3421 ttaatttttt aatgataata tatatacaaa attttttaca gtataaaata tttataaatt
     3481 tttaatttat taacatatta attaattttt tcccaggtag atttaatcaa tttattttaa
     3541 ataaaagtaa atttaattcg atatttgatt gggtaaaagt atatataata ataattttta
     3601 tattaaattt gtagtattta tgtaagaaat aaattttata taatattttt tcactaaatt
     3661 tttttctttt tacaacaaat actcactacc ttttgatata atatttttat caattattat
     3721 tatattcaag ttttgaaagg agtattaaaa tgagtttatt agttttcgga cataaaaatc
     3781 cagatacaga ttcaatatgt tctgcaattt cattagcaca tttaaagaac aaactaggaa
     3841 taaaagcaac agcttatgct ttaggagata tcagaaaaga agctaaatat gccttggatt
     3901 actttaaggt agatgcacct gaaattttag ataatgttag aatacaagtt agagatttaa
     3961 attatgataa agtagtacct ttaacaccaa cttcatctat attagaggct tataacctta
     4021 tggatgaaaa aaatgttaaa acactacctg taacttatga tgatggaact tttgctggta
     4081 tcattactat gaaagaaata gctaaaaatc tacttcatca acactttaca actatacaca
     4141 catcactatc aaacatttgt aaaaacctta atggtactat tcttgtggac tgtggtgaag
     4201 atataaaagg tagagtagtc actttatcat ttggaatgga gactctaata gagactttaa
     4261 aagaaggaga catagctatt gttggagata gatatgatag tattgaatat gctattgata
     4321 caaaagttaa acttttaata cttactaatc atacagagat ttcaaaagat ttgctagctc
     4381 ttgctaagat aaatggagtg tctgttgttt ctgttgaaag tgacaattat aaaacttcta
     4441 atgtaataaa tcaatgtagt ttcttagact ctatagaagc tacagaaaat ttaattacat
     4501 tcaaagaaga tgattatatg gatgaaataa aagagattat gctagaaaca aacttcagat
     4561 cttatccaat attagatgat gataataagt ttttaggttt agtttcaaaa ggtcatctat
     4621 taaacccatc taaaaagaat gttgttttag ttgaccataa cgaatatgct caaagtgctg
     4681 atggaattga acaagcaaac atagttgaaa taattgacca tcataaactt ggcggtattt
     4741 ctactgatgt tcctatgtca tttagagtta tgcctgttgg atgcaatagt actataattt
     4801 atcaaatgta caaagaaaat aatgttgaga taccttatga aatagctggg cttcttttat
     4861 ctgctatatt atcagataca ttattattta agtctccaac aacaactgat atggataaga
     4921 aagcttgtga agaattaagt aaaatagcaa aagtagacat ggaaaaatac gctatggata
     4981 tgtttaaatg cggtacttct ttagatgaat atactataga agaaatagta aatatggact
     5041 ttaaagaatt taatatgagt ggacatagag ttggtattgg acaagtattt accttagaca
     5101 tagactctat atttgctaaa aaagatgagt ttttatctta tataaattcg actgattatg
     5161 ataaattaat tctttcagtt acagatataa tcaaagaagg ttcttattta atctataaag
     5221 cagaagatag cttaattgct aacgcatttg gtgttgaagg tgttcaaggc acatttgcac
     5281 caggtgttgt atcaagaaaa aaacaattag tccctaattt aactactgca atcaaaaatt
     5341 ttaaataata taaaattttt aaataacgaa aactgtctca aatctatatt tgagacagtt
     5401 ttttattata tatatattga taataaagtt aaataaaaat ccataaattt aaaattttta
     5461 tgaatatatt ttattattat tgttatttta ttcattctaa aataggtaaa actcaatata
     5521 taaaaatact tttgtcattt aaataaaacc taaatagttt ttaagattat tttagacacg
     5581 ttttaagtca taacagtatc agctattcta aatatcgtca aagtagccgc agttcctgct
     5641 gattgcccat ttcgtatccc tactgttgta gatgaaaagt tatttattgt aaaagtagtc
     5701 ccaccaaata aaaaaccagc aaaatatcca gaaagtactc ctccgcctcc tggctcagta
     5761 gtaagccctg ccaaatcttt tcctcctaaa attgggaata ggatagcgaa agaatattga
     5821 tttatacttg atgaacctgg ttgtaatgct actgaaactg atatataata cacaccattt
     5881 tcttgtactg taaacgtacc atttgcatct actgttatac ttgaactatt tcctattatt
     5941 gtttgccaac ctgttatagc atctccatta tttagtgttt gtggagatgg tgcatttacg
     6001 aggaagttag caactggctg agaggaattg cctgttgctc ctgttggacc tgttgggcct
     6061 gttactcctg tcgctcctgt tgctcctgtt ggacctgtta ctcccgttgg ccctatactt
     6121 cctgtcgctc ctgtatttcc tgttgggcct gttggtcctg ttgctcccgt tggtcctatt
     6181 tctcctgtta ctcctgttgg gcctgttgct cccgttggtc ctatttctcc tgtcactcct
     6241 gttgggcctg ttgctcccgt tgggcctgtt actcctgtca ctcctgtatt tcctgtcggt
     6301 cctgttgctc ccgttggtcc tatacttcct gtcactcctg ttgggcctgt tggtcctatt
     6361 tctcctgtca ctcctgtcgc tcctgttggt cctatacttc ctgtcactcc tgttggtcct
     6421 gttgctcctg ttggtcctat ttctcctgtt gggcctgtta ctcctgttgg ccctatttct
     6481 cctgtcactc ctgtcgctcc tgttgggcct gttgctcccg ttggtcctat ttctcctgtt
     6541 gggcctgttg ctcctgttgg ccctatttct cctgtcactc ctgtcgctcc tgttggacct
     6601 gttgctcctg ttactcctgt tactcctgta tttcctgttg gacctgttgc tcctgttact
     6661 cctgtatttc ctgttggacc tgttgctccc gttggtccta tttctcctgt cactcctgtc
     6721 gctcctgttg gacctgttgc tcctgttggt cctatacttc ctgtcactcc tgttgggcct
     6781 gttactcccg ttgggcctat ttctcctgtc actcctgttg ggcctgttgc tcccgttggg
     6841 cctatacttc ctgtcactcc cgtatttcct gtcggacctg ttactcctgt tggtcctata
     6901 cttcctgtcg ctcctgtact tccggttggg cctgttactc ccgttggccc tatacttcct
     6961 gttgctcctg tatttccggt tgggcctgtt ggtcctatgc ttcctgtcgc tcctgtactt
     7021 ccggttgggc ctgttactcc tgttgggcct gtacttcctg tcgctcctct tggtcccatt
     7081 ggacctgtaa ttctaattgg aagacactca catttaggat aacaattatc tataattcta
     7141 tcttcaaatg ttacaagtat atacggtttg ttacaacctc tactagatgt aaattcaaga
     7201 atctgataag ggtaatttaa agataaagct aacccataat taggatattt attcattgcc
     7261 catgctttta tagttcccgt aatatttaaa caaatatagt tggatgtatc acttatccca
     7321 attggtaaat atcccctgat attttccata gacactctat cattccatgt tatagttcgt
     7381 aaattataat attcacttat tcttttaatt tcaatatcta ctttttcttt aaaaatatga
     7441 ttcttatttg aatcaatatg aataaataac tctgctttta atatactttt gtcttttaat
     7501 atatctggta ttctcacttt aaaaaaagta atcaactttt cttttacaaa actatttgaa
     7561 catttacttc ctattaagca ataatctaaa ttactaaagt ttttatctgg atatttttta
     7621 gatataaaag tatcatcatt taaataaagt ataatatttc tcatttataa tccctccatt
     7681 ttgggtctat atcatactat gtttaaaata catgcttagt tacaatacaa ttaaaattta
     7741 tagtattaaa tttttatata ataatgctga tttctacaaa aaaagaacat gtcattagaa
     7801 atttctaata gcatgttctt tttcattatt atatattaca ctttaaatta ttccttgact
     7861 ggcttagctg gtgtaaacta aaccagtctt tctaaaatat taagcacttt tttcttatta
     7921 tgttttttag gatttattgt ctatattatt gtaaaccaaa gttataaaat tgtaaataga
     7981 atatattacc ataacaatat ttttttataa gtaaaaatta taaaaaactt tatttttgtt
     8041 aaatggaata aataaaataa gtttaaaaaa tactgaaata agtgttttcc acatatttta
     8101 tatatttatt taatacatta ttatttaaaa ataaatatat aaacaatcat aataaaattt
     8161 ttttaataaa actttatttt ttagttaaaa tcatacaata tatagatttc cacaatacaa
     8221 ataaattaaa aagtgaaatg tatttgtcta aaaacataat aacatttcac tttatcctca
     8281 tttttaagta atatatattt ttaattttta tttataacta aatctagttt ttatataaat
     8341 tttagttttt ttctacatct gagtaatcta ttccaaaagt ttctacagta acagatttca
     8401 taatttgtgg agtttgtggc ttatcagctg aatctgttct aactgatgct atttcatcaa
     8461 ctgtatccat accttctatc actctaccaa aacctgcata ctgaccatct aagtgtggtg
     8521 agtttttatg cattatgaaa aattgagaac cagctgaatt aggtgccata gttctagcca
     8581 ttgatatgac tcctctttca tgttttaaat tgttagtaaa tccattacca ctaaattcac
     8641 cttttattga gtgacctgga ccacccattc ctgtaccatt tgggcatcct ccttgtatca
     8701 taaatcctgg tattactcta tgaaatatta ttccattgta atatccttca tttactaatg
     8761 atacaaagtt tttaactgta tttggagcta tatttggata taactcaatt ttgatttctt
     8821 ttccattttc catttctata gttactatag gatttttatt ttccataatt tattaccttc
     8881 cttttcatta gttaaattac ataattacat ttattatatt atactctaaa ttaaagtcta
     8941 tcaagtatat tttttcctat ttcatatcct tcttgataaa tagttttaca aaactcatca
     9001 tcaaagttaa gcgtgtcttt aggagcaaat tgagtattag gtctaactac tattatttta
     9061 tcttcatcat atactttttt aatatcttct ggcaactcat aattatattt tgtggatatt
     9121 aaaataattt tatccacatt atccccaatt aatggttcaa ttaatgcact cctaattaaa
     9181 cctccatcta atttgaaacc atcataaatt ccttcttgca catctttcac aaattgttct
     9241 ttaaatccaa gagttgcgtt tggatttgat ggtaacaacc cactgtatga aatgctgata
     9301 atggcttcat tacgaggcat ttttgataca tcaacaatct tttctgatac tactttatta
     9361 tcaacttcaa cataattaac ataaaagttc atttcttcta tattactatc atctagttcc
     9421 cttaggttgt ctatagcagg agaattatcc acagtattat ttactatttt tacatttcca
     9481 ttctggatat cttttatatt tgtccacatt ttctccaagt tatcaacatt ccctgtgtac
     9541 aaataatatc catttattgc tcctattgat gtccctgaaa tcgaataaaa tttatttatt
     9601 cctccatcat acaaggcttt aactactcct gcttgataag ccccttttgc tcctccacct
     9661 tctaaacata atcctaattt catagtctca tctccaaatt gtttatctta tatttatatt
     9721 tcaaaaaact tactaaatgt tttatatata ctatagtggt cctcaacatt tcctaattct
     9781 cttatagaat gcattgctaa aattggactt cccacatcca cagatggtat atctatatga
     9841 gtagaagata ttggacctat agtacttcct cctctttcat ctgacctatt aacaaattct
     9901 tgatactcaa cattagcttc tctacatata tttttataaa tagctataga atatccatca
     9961 ctagtatacg cctgactagc atttatcttt ataaccggac cttttcccat tattggttta
    10021 ttagttgggt catgcttttc tggaatgttt ggatgaatag catgagctaa atctgatgat
    10081 atcataaaag atgaataaat agactcaaag aatccctctc tatccttacc cattgatata
    10141 caaattctct ccaatatatt taacaacatg tttgaatctg caccttgttt agtagagcta
    10201 ccaacttctt cattgtcaaa tacagccatt acatttacac catgttgacc tttagtatta
    10261 acaagagcat tcaaactagc atgtaccatt gcaagattat cttgtctccc aatagatata
    10321 aattcatcat tagcccctat taaacttcct ttttcaaatt catataaaaa taaatcaaaa
    10381 tctataatat cgtccatatt tacatctaag ttagatgcta tttgctttat aagaaaatta
    10441 tctttttcta atgtatcatt taacatccca actaaaggta acatatcttt ttgcttatta
    10501 tatgaatgac catcatttat acttctattt aaatgtattg ctagatttgg tattatacaa
    10561 attggccttt taaagtctat aagcctttca tttggtttta atatactatc accttttaaa
    10621 actactctac cagctatccc aagaggtcta tccaaccatg tacttaatat tgctcctcca
    10681 tagcattctg tatttaactt caaataagat ttttcagctt ctatttctgc atttggttta
    10741 atactaaatg taggagaatc tgaatgagag cctattattc taaatccatc tctttctata
    10801 tcttctgaat ttactacaaa agctactata gctgataaat tcttagtaac ataatacttt
    10861 ccaccaactc ttagattcca tctttgattc aaaactaatt cttcaaatcc atttttatct
    10921 aagatttcct tagtactctt gactgcatga aaagacgacg gactatcata tatgaagtct
    10981 attaagtttt tagcaaagtt tatactatcc attcctcatt tacctccatt ataaaatatt
    11041 tagtgttgta tattctttat ttattttttt aattccctgt tggtcaaaag ctatagtaac
    11101 atctgtacca attatagaaa ccactgtccc aaccccaaat ttaggatgat gtaccttaga
    11161 accaagtttt atatcatctg gattagtttc tttattagaa tcttttattg tagcattaac
    11221 tttatctgca actttagatt tgcttatagt actcatatac tttttagtat atttatctaa
    11281 catattataa cttgctttag aatagcttag ttcttttttt actttgtaca atctttctat
    11341 acattcttct ggcagttctt ccataaatct tgaagctatt gcaacatttg ttttaccata
    11401 taatgttctc ttctctgtca atgacatata tagctcttct ttagctctag ttataccaac
    11461 ataacaaagt cttctctctt cttctatttg tgaatcactc atagatttta tagctcttga
    11521 tataggaaat aacccttctt ccatacctgt taaaaacaca acagggaact ctaaaccttt
    11581 agatgtatga attgtcataa gcgaaaccct atcattgtct tcttcatcat ttgattcaga
    11641 tgtaagtgct atacttgtta ggaatgtctc taagtcttta ttttcataag tatcatcatt
    11701 actactttca aactccaaag ctatagaaat aaattctctc aaattatcaa ttctgtcttg
    11761 agcttcttca cctttgcctg ttaaatcttt ttcattttta tttcttatct ctacaagctc
    11821 gtccatatat cctgtagtgt ccaagacttt ttctataagt ttgctaacag gataaacttc
    11881 ttttatagtt ctaagagtcc ctataatatc aacaaatcca cttatacttg cccttgcctt
    11941 agtagatata tctgaatttg tttctatatc aattaatact gagtatatac tttcctgttt
    12001 taagttagct ctatcttcaa ttttttctat ggttctaagc cctatacctc ttctaggaac
    12061 atttataatc ctttttatag atatatcatc ttgtggattt tgaataactc ttaaatacgc
    12121 caacaaatcc tttatttctt ttctctcata gaattttgta ccaccatata tattgtatgg
    12181 aatttgactt ctatttaaag cgtcctctac aggtcttgcc tgtgcatttg ctctataaag
    12241 tactgcaaaa tccttataag gtctattttc ttttctagct atttgtgcaa ttgaatcagc
    12301 aatgaaatca gcctcttcta tttcactacc agttaattgt atctttataa gttctccttc
    12361 ttttttttca ctccaaagct tttttctttt tctttctata ttattagata taactttatt
    12421 agctgcatct aatatcactt gtgtagacct ataattttgt tccaacttta caacatgtac
    12481 attgtcataa tctttctcaa attcaagtat gtttcttata tctgcacctc tccatccata
    12541 aatactttgg tcatcatctc caacaacaca aatattttga tgttctcttg ctaataattt
    12601 tatcaattca tattgagctt tacttgtatc ttggtactca tctaccatta tgtatctaaa
    12661 tctacttctg taatatgcta acacttcatc attagccttg aaaagttcta cagttttaag
    12721 tattaaatca tcaaagtcaa gtgcactatt tctttttaaa cggtcttgat atagcgcata
    12781 aatatctgca atcttaacca ttctattatc tgccatattg atatctttaa actgctttgg
    12841 agtataaagt ttatcttttg ctcctgaaat tgcacttata actgcttttg gttcaaacac
    12901 tttatcactt aaatttaatt cttttagaca gtctttaacc aatgtaactt ggtctgctga
    12961 atcataaatt acaaaacttc tattgtaacc aatcttattt atatcttttc ttagtatacg
    13021 aacacagcaa gaatggaatg tacttatcca catatcctta gtttcaggac ctatattttg
    13081 ttcaactctc tctctcattt catttgcagc tttgtttgta aatgttatag ctaatatatt
    13141 tggtgcttgt acacctttat cttctataag atatgctatt cttgttgtta ataccttagt
    13201 tttacctgaa ccagcaccag ccagtataag tactggacct tcagtctttt ctactgcttc
    13261 tctttgagca ggatttaatg tatctaaatt catatttctc ctcctgttaa cagccataaa
    13321 tatattttaa tctaaaatat gaattacttc aaattataat tatgtattat attaatagat
    13381 tatttccaat atattacaat taaataacat ttttccatat aatttatttc attgtttaat
    13441 aaaaaaaata accttatgat ttggggaatc ataaggcacc tttaaggggt ctaggttaag
    13501 ggttattata tataaatcta tttttttaaa ataggtttag ggcttaatta tttatttgta
    13561 ttaagttctc tttccttcca atacttatac aaatcttctt ctttcttaaa taagggtaaa
    13621 ttcatatttc tatgtacttt tactaaccat ggggattcta ggccagcttg tataatatta
    13681 ttttcattta taaacacatt ttctgctttt ccttcatcaa tcaaaatccc cttatccaat
    13741 acatatatgt aatcacatat ttcatacatt aaattcatat catgactgga tattactatt
    13801 tttatattat ttttatttaa tccctttatt atatctacaa tagacctagt acttactggg
    13861 tctaaaccag ctgtaggttc atcaagtaat acaatttcat tttccattgc tataactgat
    13921 gctattgcca ctcttttttt ctgtccatag ctaagaaaat gtactggcct gtctataaaa
    13981 tctattccat taacagctac tagagctttg tttattctct ctttaattgt tttttcatcc
    14041 ataccaatgt ttctcattgc aaaggctata tcatcatata cttttgaata aaaaatttgt
    14101 ttttctgggt cttggaacac aatacctaca ttttttctaa ggttgtataa acttctctta
    14161 tcatatttta acttttcttc tttaaaaaga atttctccag atgtaggctt taatataccc
    14221 attaaattca taaataatgt tgattttcct gaaccatttg aacctattat acctataaca
    14281 tttccctttg aaaaatccat attaatgttt aatagtgcat tggtattttt ttcatattga
    14341 tacgttaaat tatttatttt aaacatcatt atcccctact atgtgaaatt taccatcata
    14401 caattttatg tctaatgata tacacatatc atcatacctt gtcataagtc ttttgtacag
    14461 catacttcca agaataccta aggatttata tgaagttttt aaatttatat atccaaatct
    14521 tagctcttgt gacttgtata tttctgaaaa ttcttctaaa aatatgaata taaacctata
    14581 tattaacatt gataactcga caaaagtgtc aggtaaatga agttttttaa aaaagaatat
    14641 taattgatta aaaggtgttg taagtataca aaaatacaca caagtcaaac aagacatcgc
    14701 tctaaataac acatgaatag acatgtcaat agacgccttt gatattccta cattaaaact
    14761 aaaaaattca aaactatata ataaatctgc tttattaaaa gatatattta caagagttat
    14821 tcctatacta agaaataaaa agtacattgg tattctaagt aattttaaat aattttttaa
    14881 atctattcca gccacacaaa caaccaaaat actcattaaa atcataattc cacttaaaat
    14941 aaatatattt tgtattacca tagaagcaat cagaaaaatt actcctatgg ctactttttt
    15001 gtttggattt actttactca atctatttgt atatgcatat ttatcaatta taagcatgat
    15061 taacttctct ttcctttttg aagacctaat atgtatccta ttacaccagc ccctaaagct
    15121 gcttgtgcag agaataataa actttctatt tctccacttg gtggctcata tggactgcta
    15181 aaccatggtt tgtaatttgg atttatctta gtaatttcac tttcagcttg accatctgct
    15241 cctccatatt cagcacctga gttgacaagt aatgggaata taataagagc tactactaat
    15301 aaaagtaata atatgttagt ttttgtttta gcactcatta gctttaactc ctttatcatt
    15361 attttctagt atgctttttt ctccgttttc tgtaattaaa ttatatacaa ttacagtaag
    15421 tataccttct gctattgcta ttggtatttg agtcataaag aaaattccta aaaatttaat
    15481 tgctgaagcc attaccccac ctgatgggtc tgggaaagcc agtgctaatt gtattgaagt
    15541 tattgtatat gtggctaagt ctcctattgc tgctgcaaga aatactggaa tagcattatt
    15601 tccatctttt ttctttaaag ccttaaatat taggaatgat acgattggcc ctattatcgc
    15661 cattgaaaaa gcattagctc ctaaagtagt tattcctcca tgtgctaata acaatgcttg
    15721 gaatattaaa actatagttc caagaacaaa cattacgctt ggtccaaaca ttattgctcc
    15781 aagacctaca ccagtaggat gtgaacaact tcctgttact gaaggtattt ttagtgctga
    15841 taatacaaac acaaatgctc cacataaagc taataatact ttctttttag ggtcttgctt
    15901 tactatttta cctattgatt ttaatccgaa taagaaaaat ggtataaata taactcccca
    15961 tgctatagac cattttactg gtaagtaacc ttccattata tgcattgcat ttgatgtaac
    16021 tggagttaaa atgattaaca taagtgcagc tataacccct aatttaatat tctgtttcat
    16081 cttagtatcc ctctctccct ttctaataat taaaacataa taatacatgt ctgatttatt
    16141 taataaaata aaaaagccta actcgatggt taggcttcta attttccaca atctaaatac
    16201 aaacacataa aacaaacata tctgtataat tattataaga aactttctcc atccccgaag
    16261 aaattacttt aatattttag gcaggtctcc tgacttagct tcatcctact cctcttcctt
    16321 cccatgagat ataaaaaata tcatcatagt ggctaacaaa agtttcgtct gcatcacagt
    16381 agcgggggct gtaaaggaat ttaacctttt tccctattaa tcttgcttaa agaacctata
    16441 atattatata tttaattttt aaattcttct taaattattt tctatataaa tcattgtata
    16501 ccttttctgt gaaaatttct acatttttta taaattttat tcatttttat atttttatgt
    16561 atataaattc ttttttgtaa gtttattaat ttctaattat cttctttaaa tacattgaaa
    16621 ctacatcaga aaatctagtt atatctcttg aatatataaa atcatttcca tatattaatc
    16681 tttcagcttc aagttctgat tcttttcctg taaatactcc taatactaat atattttgct
    16741 ttctagcttt tctcacttca ttggctgtat ctctcaaacc aactataccc ctataagcct
    16801 tttctcctct taatgttctc tcactacttt ttcctatctt tacatcattt ggtcttccat
    16861 cactgagaac tatcaggatt ttattttctt catctctatt tattagacca ctacatatag
    16921 attttattgc caaaccatct ctattattac cagcacaaaa atattcaaat atattttcac
    16981 tattttttat actatcatca taatctttaa atctttttaa tattgtatag tctaaaaaac
    17041 tagaaaatcc catcactcta tttggtatgc caacttctgt tagagcattt gcaattatgt
    17101 aagcttgaat tgccacattt ccctgatttc tactttgaga gccacttgca tccaataata
    17161 tatcaataac gtatttccct ttttcatttt ctatatcttt ataaaatatt ttattattat
    17221 tacttctacc aactctccaa gctctattgg ctaatatagt accacaatca gaatatactc
    17281 tacttttagc attttcttct attaaaattc ttgatagact ttcttttaat ctctttattt
    17341 gctgtctata cattctagca tgttctctaa attttcctaa attattttct ttttgtcttg
    17401 ttacatattt tagttgaaat acattattac actcacttct aagaactcca tctgtaaagt
    17461 gtattctaca accttcatga acatttctac aattttgtgt ctcaattttt ttaatttcac
    17521 ctttactcaa ataagttttt ccataataat gttctatttt tgaatatatc ttatttgcag
    17581 tgtcttcatc aacatatata actcggtctg ctgaattgct acatttagaa tcatcaaaat
    17641 cccctacacc ttctacaagc atggatgaag atattgaatc tatatcactt tcaataatat
    17701 tttcttcttc atcactataa agttcttcat acatgaaatc agcaaatgta tcaaaattta
    17761 cttctacact ttctacatta ttttcatcaa taagactatt ttcttctcca tttaatatgt
    17821 attcaaaata agttaaatat ataacatcta atgcttttaa aatctccata atatcttgat
    17881 tggtatctat atttcttata tcattaacta ttcttctagt catactatct aatgctgggt
    17941 gcttgtccat actataaagt acaaatgtgt atttaatttt atccataata ttatcattgt
    18001 gtattttggt aaaacgtgaa acaatatctt tataagcatt tcttcttatg tcttctatcc
    18061 ctggcctatc tttaatgacc ttttcttcaa ctattgtatt taatataact tgaattagac
    18121 ccagtataat atctttgttg tatccttttc ttattctatt tgtaagatat tttttaacta
    18181 tatcccaatc tacatacttt cttctagcac ctgcaattat tgcaaaatat agacctattt
    18241 cttttgaaga gtaatctttt tctgatatat ctatactttc attgtaatca ccagctattg
    18301 tccatgataa gttattagct ctattttcaa attcataatc atcatatatc catttcataa
    18361 tctcacctat attaaatatg acttattgga aacacatcta tactctccca tttattaggt
    18421 attctagttt taattacatc tccaaccatt tctttctcat atacatcaaa agtctttcct
    18481 gtaagtccca tattaattgc aagagttggt tttaatcctc ttcttatagt cttaagagat
    18541 gccataagac cacgtaaatc aatagcttta ctagatatct ctccattttg agacttcaat
    18601 tgtaaatcta aaaatattcc tgcaaagtgt attagttttt cttcatcagc atctgaaaat
    18661 tcatttttta aaatcatcat taacttatct tcttctatag gaggaatatc tattaccata
    18721 aatctagata ccagtgcttc attaagttct tttgttcctg catattcata attcatagtc
    18781 ccaataaatc ttgttgctgg atgtagattg actctctcat acccaggtac atcaattatt
    18841 cttctatagt ctaaagctga atgtaccaca actatagcat cattttttgc catattaatt
    18901 tcatcaaaca ccccaaaacc tccattaata gcacactcat aaactgagcc tcttctaagt
    18961 ttaacttcat tgtctataaa tgtatctgta cctataagtg ttgaactgtc tgtatttata
    19021 tgaaatgatg tattccactg aggtctatta aatatttccc ctagattatc agcaagtaag
    19081 ttttttcccg ttgcctttgg tcccgataat aatatatttt cttcttctaa aatagctgct
    19141 atacacatag acaagatatc tttaccataa aaataagttt tagactttgt tactctgtat
    19201 tctaaatctt tttctaatcc ataataattt ctaaaataca gtacatcttc aataagtttt
    19261 tcatctaccc cttgcaccct tagattatct attatatcca tatttttacc ccttttatat
    19321 aaatagtatt tgtttcattt cttatcacca ttttagcata aaaggatata agctaaaatt
    19381 gattttttaa tctcccccat tttaagtaaa accatgcacc attttatcac tacaaaatta
    19441 agagtactac ttactgatat ttcttgattt tattcgtcta tacgtatata atatatactg
    19501 ataaattatg aggaaaggat gattgaaata tggaatatat gtcttgccca gaagtagcaa
    19561 aaaaatgggg tatttctgaa agaagagtac aaaaactatg tgaagaaagt cgcataccag
    19621 gagtttcaaa actcgggtat atgtggctga taccaaagaa cgcagaaaag cctgttgatg
    19681 gtagaacaaa aagaagaaag gaagtacaat atgaatagcg ttttgattat agatgatgac
    19741 aaagaacttt gtgctcttat gaaaaaatgt gttgagcaag aaaatttatc tgctattact
    19801 gcacatggtg gtgcagaagg tctacattta gtcgataaaa atagacacac actctctctt
    19861 gtaattttgg acataatgat gccagatata gacggttttc aagttctgaa aaaaattaga
    19921 gaaacaagta atattccagt aattatgctt actgctaaaa atgacgagga tgataaagtt
    19981 tccggactac gtttaggtgc tgacgattac ctaacaaaac cgttcagcat aaacgaactt
    20041 atggctcgtg tcaattctct tattcgtcgg tatactatgc taaaccctgc ttttataaca
    20101 gacacagatt tcataataat aaatggcatg attattgaca agacaaaccg aattgtttct
    20161 gtcaataata ttcctgttca acttacaagc aaagaatttg atttacttgc ttttctggct
    20221 tctaataagg gacgggtgtt taccaaaaaa cagatttata cacaagtatg ggaagaagaa
    20281 tatgcttttg acgatagtaa catcatgtct ttcatcagta aattgagaaa aaagattgaa
    20341 ccagacccca accatccatt ttatattttg acagttcgtg gtgtcggtta tcgttttaat
    20401 aaggaggctt aacatgaata caagtgtcta tctgcttttg atattggctc ttagcctgat
    20461 tattatagcg taccttgttt ctgtcctgct acgtgtccga atacaactta cacttataaa
    20521 agatgcttta gaggatataa aaaatggaaa ccttaatcga cgtattttaa cagatgaaaa
    20581 cgacattaca aaacaaattt gctatgatat taacgaaata gcaatcaata gccaatttca
    20641 acttattcag caaaaacaat cagaacaagc ctacaaacag ctaatgacaa gtctctccca
    20701 tgatgtaaaa actccacttg cttctttggt cggttatttg gaagcagtag aaagtaaaat
    20761 tgttgtagga gaggaaaaag acgagtatat ccatgttgcg tctaataagg ctcattactt
    20821 aaagaatttt gtagaaaatc tatttgaatg ggtaaaattg gattctaagg aacaagtttt
    20881 tcattttgat atttttgact tgaatgaatt atcccgtaat attatatctg attggatacc
    20941 tgttttagaa agcagtcatt ttgaatatga atttgatata ccagaaatag agtacttctt
    21001 acgtatagac gcaaatgcat atacccgtat cattaataac ctattacaaa atattattac
    21061 ccatagtagt ggaaacaaaa tgacattgag aatttttgaa aacaaagagc aagctcaaat
    21121 tataataaca gataatggga aaggtatatc ttcagacaat ctcccacata tttttgaaag
    21181 gttgtaccaa tgcgaccatt cacgagcttc aaagggaaat ggtttaggct tggcgattgc
    21241 aaaggaactt attaacgctc ataagggaaa tattaccgcc aacagcactc ccggtatggg
    21301 aacagaattt acaatattgc ttcctaaagc cctgtaaaag tacgaggctt tcttactcta
    21361 aaacaagata aaagcaagat tatggcaagg ttttggcaag gttcatgttt tataattcta
    21421 attgtagttg attttgacgt tgtatcaact atcttttgta gaaacaaatt tattaaaagt
    21481 gaggaaatta tatatgaatg attttgtgat tgaaacaaag caacttacaa aaatttatgg
    21541 gaatcaaaca gtagttgaca aagtcaatct ccatgtaaaa aaaggccgaa tatatggtct
    21601 gttaggacgc aacggagctg ggaaaaccac aattatgaaa atgattttag gattgacttc
    21661 aatcacgtat ggcgaggtag atgtatttgg agagaatatt aagggacgtg aaaaacaagt
    21721 atatccccgt atcggtgcaa ttatcgaaac gccaggattt tatcctaatc tgacaggaac
    21781 ggagaacttg gagatttttg caaaactgcg tggtacagcc gcccctaatt ctgtaaaaag
    21841 agcattggaa attgtaggct taccttataa aaataaaaag ctgtttagta aatattcact
    21901 tggcatgaaa cagcgacttg gtattgccaa cgctatcctg catgacccag aactgttagt
    21961 tttagatgag ccaaccaatg gtcttgaccc tattggtatt gcggagatga gaaagtttat
    22021 tagggacttg agcgttgagc atggaaagac aattcttatt tccagtcata ttctttcaga
    22081 aatctcattg ttggctgatg atattggaat tatcgaccac ggtgttcttt tggaagaaag
    22141 tagtatgagt gaactagaaa agaaaaacag taaatatatc ctgctacaag tttcagatat
    22201 tccgaagaca tcacttattt tagagcgtca atttaacacg aaggattatt ccgttcaaga
    22261 tgactacacg ttacaccttt ataacactaa tctggatatg ggtgaaatca ataaagcact
    22321 tgtaatgcag aatgtaactg ttattagttc tcaactttgt aatgatactt tagaggacta
    22381 ctttaaaaaa atcacaggag gagagggcat tgcttaaact tattcaaaca gaatttctta
    22441 aactgcgtcg taggaaactt atttggctga tgttgttgtc tgctctcatt atgccgtttt
    22501 tcgcactact atacttcaat tattttggta aaacaggtgt tgagccaata aagttttata
    22561 aatggtctgc atttggttat acactttgga ttattttgcc tgttgttttg ggtatatttt
    22621 gcaccatgct tatacacgaa gaaaaccagt atgatatgct caaacagctt tggattgtac
    22681 ctattagtaa aatgggatac ttttttagta aatttttcgt tgttttgatt tactctattt
    22741 gttttatgct gattacagcc gttgcttctg tgttatttag tgtactttct ggatatgtcg
    22801 tatttagctg ggcaagcatt ttatatttgt tgaaaaaatg tttagaaatt ggtgtaatca
    22861 ctgcttttgt aatgttgccg attttggcaa tcgctacatc tcaaaaagga tacattctcc
    22921 caatttgtat cacattggta tatgcctttt ccggttttgt tataatgaca ataaatatgt
    22981 atttacaccc attatccagt atgggagtta ttatcatgag aaataaagac attccaggtc
    23041 ttatattttc acaggaaatt aatgtcccat tagcatttct ttgtatttgt atttggagta
    23101 ttgtatcagt attgtttgca aatattgcac taggaagaag aaagtgaggt gtagataatg
    23161 tggaaattac tttgggctga atgtcaaaaa attcgtcgtt caaaaattgt ttggattaca
    23221 gtttttgcat ccattatgat agcagtcata gtttttgcag gggggcagga tgtatataat
    23281 gacccagatt tacattatgg cttaaagagc gtttatgacg gttcacggta tatagacaat
    23341 gcaggttggt atatggacgc agtacaacct tggtcaactt tttttgttct tcctgctgtc
    23401 attgccctat taggaagcta tattatttgt cgtgaagaag aggaggacac tattaaatcc
    23461 ctgcgtctta ttcccataaa tgaaacaaat ttaaccatag caaaaatgat tattactttt
    23521 atattcagta tacttcttta tttgttactc tttactataa catttttgac tgaatccgtt
    23581 ttacattttt ccgatttatc gacaaaattg gttttaagtt gcatgaaaga gtattttctt
    23641 gatggcatag gtgtattctt tgcaatttct cccattattg ccttggtatc gcgcatgaaa
    23701 aaaggatatt ggcttgcatt agtattcaca gaagtttatt ctattgctgg actatttgcg
    23761 ggtatgtcaa atgtcttaca aacctttttt cctattgcgg caatatttaa tatttctgga
    23821 tactatataa ctactggaga aaaaattatg gggagtatca tgagtttatt actttgtgcc
    23881 tgcctttctg catttatact taaagggcta aaacacaatg aaaaaaattg aaataggtat
    23941 atcaaaatga aaaagataaa aaaactgatt attctaattg tattcttgtt tctttttggc
    24001 atgttacact gttatactga atggaaattc aacaataacc cacctaaagg ggtaatagaa
    24061 agaataaatg agtggactga taagattgga ctggattagt aacttatgtt aattatagtg
    24121 aatgtaatat tagcaagtta ttgtttcgta ttttaatact ataactttaa atatttggtt
    24181 ttaatcttcc aaacgaatat aaaaaaactg tcacagaggc aacatatttt tgaatattta
    24241 taaagtggta gttttgattt tcaaagctac cgccttttct tctatataag caaacttatc
    24301 ctcaacaaag tgtaaaacat ggtgcatttt aagaaaaaag taccacagac acaagcaata
    24361 aaagaaacgc cgagaaccta caaaaacgta gtgcttatgc agatttacga cgccttctat
    24421 tttctcaacc gtcttaatga ccttgtacaa aagaaatttt tctaatattt tttataatct
    24481 tatcttgtga tgttttttat gtataaatga cttaataaca aatccaataa aaattatgga
    24541 tattggtata attagaacga ggaatttata atcattataa tgtgacatta ttcttaccca
    24601 actctcagaa aaaatatatc ctatactgat taatgaagta ttccatatgg ttattcccac
    24661 gatagatgat attacaaaag ttataatatt ttgacctgct atacctgcta taaaagatat
    24721 gtatgttcta cataaaggga ttaatctaca tacacaaaca gaaatagaag agtatttatt
    24781 aaaataatct tgagatgcaa atattccttt ctttgccttt ggacatatct ctattatttt
    24841 atttatgata gatttacctc cccaatttcc cactgtataa caaaatatcg aaccaagtat
    24901 acctgcaatt atacttaaaa ttaaaattgt cagaaatcca aaatgatttc ttgcagcaat
    24961 tgctccacat aaaggtaaaa caacttcgct aggtaatgga aaacaagcat actcaatcat
    25021 aattaataca aatacagaga ttaatccata ttgtaaaata aaactattga ttacagacac
    25081 ttacttatct atctcctttc ttatttaaag gttttaaggg tacatgttct aaggattctc
    25141 accctatatt taaagaatca atctctttaa actattatat gtatttacac aaagcattta
    25201 taacatactt taaaaatagt accttaaaat aagaaactta ataaataaaa aaagattacg
    25261 tggctacgtc ctactctccc aggcagtttc ccaccaagta ccatcagcgc tagagagctt
    25321 aacttctgtg ttcggaatgg gaacaggtgt atcctctctg ctattgtaac cacataatct
    25381 ttatgcttaa tatttccatt aagtttttaa taagtttata gaacctagta atactagttt
    25441 ctttagagtt a
//
LOCUS       DAEPID010000054        25436 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.054, whole genome shotgun sequence.
ACCESSION   DAEPID010000054 DAEPID010000000
VERSION     DAEPID010000054.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 25436)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 25436)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..25436
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.054"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            1381..1770
                     /locus_tag="KR257_002518"
     CDS             1381..1770
                     /locus_tag="KR257_002518"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426867.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="BlaI/MecI/CopY family transcriptional regulator"
                     /protein_id="HBH0031200.1"
                     /translation="MTIKKLPQSELKIMKFIWKSDSKVTSRDIVLGMEQKYQWKQTTT
                     LTLLSRLVVKRFLNSQKIDKYTHYEVLIKEKEYIGVETRDFFRNIHDSSIKSLLLSLH
                     ENINLSKDDILLIEEWIKNLKEEEKDV"
     gene            2504..2974
                     /locus_tag="KR257_002519"
     CDS             2504..2974
                     /locus_tag="KR257_002519"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895702.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glyoxalase/bleomycin resistance/dioxygenase
                     family protein"
                     /protein_id="HBH0031201.1"
                     /translation="MKYQVSLLAVKDIEVSKKFYKELFEQEIELDLGKNVTFKGGFAI
                     QEDFAWLTGINPDTIIQKSNNMELYFEVDDFDEFIEKLNYYKDVEFVHKPLKHEWQQR
                     VVRIYDPDKHIIEIGESMEVIARRYLSEGYSVEETSKIIQHPIKFVKQCENSKE"
     gene            3278..4147
                     /locus_tag="KR257_002520"
     CDS             3278..4147
                     /locus_tag="KR257_002520"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426876.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Nif3-like dinuclear metal center hexameric
                     protein"
                     /protein_id="HBH0031202.1"
                     /translation="MVIIKAIELYKKLDLEFNIKNINDDWSFMNFENDFITPEFRKKY
                     IGLVLDNAQNINKVYTTTFPDKEIIKQVIDKDEKDILIFSHHAMGYIASDEGFPFHDI
                     PLSYMEEMKNRRISFYVLHSPLDNYSDYSTSVSFAKAMGLEIVKPFCKYDDKIEVGVI
                     CKTSLKSIEEIKELIKKSVGHDVKLYDYGDSVLKDGLVAIAAGGGSYPFVAREVAELG
                     INLYITGFTKPLKHFEPVLEFHQIAKDNLINVIGATHYSTEKFACMGMVDYFKNLGLE
                     SEFLQGKYYLEDL"
     gene            5022..5729
                     /locus_tag="KR257_002521"
     CDS             5022..5729
                     /locus_tag="KR257_002521"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426879.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="methyltransferase domain-containing protein"
                     /protein_id="HBH0031203.1"
                     /translation="MIFTKSNKYDKDFLMKNMMGPNCIKILEELTSKIKLEKGMRILD
                     LGCGKGISSIFLAKEFDATVFATDLWIEPTENYKRFKEFKLDDKIFPIQAEAHELPYA
                     EGFFDAVISIDSYHYFGNKEGFLDNHISPLVKEGGILAMAMPGLKEDFVDCIPDELIP
                     FWQDNMNFHSITWWNKLWSESESVIVEKCEALNCHDEAWKDWINCDNSYAINDKKMME
                     VENGKYFNTISLIARTK"
     gene            6328..6828
                     /locus_tag="KR257_002522"
     CDS             6328..6828
                     /locus_tag="KR257_002522"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418206.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HBH0031204.1"
                     /translation="MIEGIKFIKAEEKYIYSYWQTFDKIAKERKYLAMDEAFPFEETV
                     EFIKNIINKNLPQLFIIDLESDNCIGWCDVLPKTEKVGYLGMGILKEYREKGIGSNLL
                     KQIIDLSKEYGYEKIELDVFKSNSRAIHVYKSLGFVEVNTISSGFTWNDRPVKEEVIQ
                     MELTLI"
     gene            complement(7078..7857)
                     /locus_tag="KR257_002523"
     CDS             complement(7078..7857)
                     /locus_tag="KR257_002523"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895707.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0031205.1"
                     /translation="MNKNILNNSFPEVPESFHNSLSKTLNSLPEREENYKMINNKTHK
                     LPFRKGLVATLAITLILSTTALAVGHIYSLVGKSSTKATYTSIPTTEQVKKDFNFTPN
                     IVSEFSNGYKFKGAYTVNKKAFDKENNVLGKSKALSFEYKNGNDEISLDTANNVLGKS
                     SDNLKVVDTYKDINISYEAFAQKFVPEGYKMTEQDKIDEKSGKYTFSVGPNNESDKVE
                     VNKFKFLTWKQDGVYYSFTVQDSNLSMNDLVKMAHEVIDAK"
     gene            complement(7854..8333)
                     /locus_tag="KR257_002524"
     CDS             complement(7854..8333)
                     /locus_tag="KR257_002524"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895709.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sigma-70 family RNA polymerase sigma factor"
                     /protein_id="HBH0031206.1"
                     /translation="MDKTTFTNNILESEQTLYRVSKSILGNDQDCEDAVNNAILKAYE
                     KLDSLKEEQYFKTWLIRIVINECNSLRRKRLKSLSFEDVFKNKKIDEKDDYSDLYTAI
                     QSLPKKIKIPIVLYYIEGYSVDEVKEILDIPQGTVKSRLSRGRRLLKTKLENTEVII"
     gene            9319..10326
                     /locus_tag="KR257_002525"
     CDS             9319..10326
                     /locus_tag="KR257_002525"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895717.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nuclear transport factor 2 family protein"
                     /protein_id="HBH0031207.1"
                     /translation="MGKYQDSKKVVRNYFEALENATGDEVENVLKQHMKSDYNWKGVY
                     PFREQEGTENVADVFWKPLKKSLSNMQRRQDIFIAGTNEIDNSEWVMSMGHFMGLFDN
                     DWLGIKHTRKMISLRYAEFNCVQDGKIAKTGLFVDIIGFMIQAGVNPLPPQTGSYFVY
                     PGPIDHNGLLFEDADEVEGVKTLALVNKMVDDLSELNESGAMGCPPEILEKSWAKDMI
                     WYGPGGIGASYTIPRYQEQHQLPFRNNLKGKTFNGHVCRFAEGNFACFFGWPNLTNVP
                     CGGFLGLPGGEVKADMQVVDVYYRKGDKLQENWVLIDIPYWLKQQGLDILERTKSIFN
                     A"
     gene            10364..11791
                     /locus_tag="KR257_002526"
     CDS             10364..11791
                     /locus_tag="KR257_002526"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895719.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ester cyclase"
                     /protein_id="HBH0031208.1"
                     /translation="MASTNKNNATSKEEEKEVSTSGLESCTVKENKAKMNQTNFSNIN
                     ENQTNENKTNTYKRNIDKGNIDKGNIDKTNTNKSDINKVNIDTVDTDKLNTNTLTKKN
                     KKVIFKGEDNMSSTKIYYGDSLEVTPVGVMDYNDFSKQTKREQEIPGFDSKYRDFVDY
                     IMKITHNIWEEKGIGVIYDTYHNNVTMHCGSSNLVGIKDVISNTLQTLHAFPDRRLIG
                     QNVIWSNFGADGFLSSHRVLSTATNLGDSNFGPATGRKINFRTVIDCATTNNRIHEEW
                     LVRDNLWIVTQLGLNPQEVAKSMAKASESKVLSLQSTYGICESMDGQFMPTKYQAKDD
                     SAGEMMLEMTSRIYNYKYINEVKKYYHDNAVVHFICDKDLNGYDEIQGMIVSLLASIP
                     NGSYEVERVTCNQREKNEGYDVSVRWRLRGINEGIGFFGQPSGKHIEVMGINHYHILQ
                     GKVKEEWITFDGMDVLKQMYMGVEE"
     gene            11933..13198
                     /locus_tag="KR257_002527"
     CDS             11933..13198
                     /locus_tag="KR257_002527"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429726.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MFS transporter"
                     /protein_id="HBH0031209.1"
                     /translation="MKTTVEIENDIILGKDYSNLKRGIAFFSIALIYFFYCYNFMVGT
                     FIKPTMIYALADGGFGFSLKQTEEIFAVMSFGTIPGTFIFGVISTKIGKKRTLISVAL
                     LIGLTTFIPMLSPTNIMLWKIARLCTGVVLGGVFGTAMPLVADMFPSKYRGKLAAILT
                     ALFSLAMIFGGKVYGVLGDANWQILMYTAIIPPIVGAILAIFFVPDDLEYTKELVKKG
                     KETGEKISYISMYKGKYLWIGLGTILLSGANFTAYSAFSNNATTYLVTRIGMSAAVAG
                     SIYSLQGIGQLVGYLFWGSIADKFGRKIPFIGMALAAVFVFIYTKLGGDNTTTFYMIS
                     VLLGVAVGYSGAWGAYYTELFPSKYRSLSSGMSFNGGRIISTFAIPAIAGTASGTLGM
                     MTIFYISIAVFVAGAIVWLFLPETLNNKK"
     gene            13240..14838
                     /locus_tag="KR257_002528"
     CDS             13240..14838
                     /locus_tag="KR257_002528"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003432878.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sodium:solute symporter"
                     /protein_id="HBH0031210.1"
                     /translation="MISSIDVCIIIGYLLLMLVIGYYSGKDNKNQEDYFLAGRSMPWI
                     PIALSVAATMISANGFIGGPGWAYVDGMYPVMVNITVPLAIFFALSITTPVIYKLKIT
                     SIYEYMGLRLGNYSRGLTIIQFFINSLIQASSMVYIPVLIIQMITGWSLYALVPIVVL
                     VSIIYTLLGGIKAVIWTDSIQMIVVISAVFIVIIVALKGMNLSFFDTLQIAQQSGKLN
                     TFDFSRDISVTNTFWATLIGGTVMWIRYFCFDQSQVQRVLTSKSLKCAKNSFVVSAFV
                     MNLVYYFMLLVGVILFVFYGGRTFETSNEIMITFILNELPVGAIGIIIAGVFAAAMSS
                     IDSILNSMTTVFTKDIYEFYFKKDNKESSLKVTMIITVVIGVVMTGFIIMGFGGSIKS
                     ILDLVGNYISYFAGPATGAFVLAMFTYKANDKGVSIGFIVGLVLGFFISNKYNVSWLW
                     NPAIGATITLIFGYIFSVILKKNHNADDIKKYTAFGMRNHLISQGMDKVDGVSIVPFS
                     LGKQELIVLAFFIIQYIILFLIQF"
     gene            14873..15895
                     /locus_tag="KR257_002529"
     CDS             14873..15895
                     /locus_tag="KR257_002529"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892750.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LacI family DNA-binding transcriptional
                     regulator"
                     /protein_id="HBH0031211.1"
                     /translation="MNQKKVHYNKSATSKDVARLAGVSQSSVSRAFGSANGKGVKPEV
                     RERIFRVANEIGYVPNLVARGMISGKTNVIGLIVGDSLGPFYNRIINLFVEKIQEIGK
                     QCLVFKVPRQQSIDSIISKVIQFQVEAVIITASAMNKVMAETCEENNIPVILFNRFIP
                     GIKISTVYVDPIEGGGMAAEYLLKKGHKNIGYIQFTRETSEEMEKKIGFYSKLRQSGI
                     HNLKEESANYDYDSGYEAGKRMLALSNPPTAIFCTSDLIAIGVMDAARFEYKLRVPED
                     LSVIGYDDIQMASWKSYNLTTIRQPLDLLIEKTINILKSLLNEENPESVVEMLKPELI
                     ERGSTL"
     gene            complement(16283..17686)
                     /locus_tag="KR257_002530"
     CDS             complement(16283..17686)
                     /locus_tag="KR257_002530"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418212.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AAA family ATPase"
                     /protein_id="HBH0031212.1"
                     /translation="MKMLNNFFKKINNPAPVFAQTKMERDNQTDDSLSTKPKTTFRDV
                     AGLDEVKEELFEIVDFMKSPQKYQKMGAKIPKGVLFYGPPGTGKTLLASAVAGETNSS
                     FFNVTGSEFVEKYVGVGAKRVRTLFEKARKEAPSIIFIDEIDAVGAKRHLESNNEKDQ
                     TLNQLLVEMDGFNKDSNVLIIGATNRLDLLDEALLRPGRFDRHIHIGAPNYHTRFEIL
                     KVHTDDKPIDKSVNLELLAKKTHGFNGAHLSNIANEAAIFAVRDDSECITSEHFDKAL
                     ERVIAGLESKNSALVEKEKKIVAYHEAGHALVSDIVGICPIQKISIVPRGQALGYVLQ
                     LPDEDRYIYTKDELIGKIKILLAGKASEELIFNHKSTGAKDDLKKVTEIANQMVCEYG
                     MSNLGFMTIDGNDKTFLCDKVQKEANRIVEICYKETLEMLKDNLEDLHSVSKFLFEKE
                     TMTHEELKDLIGKEAVN"
     gene            18553..19062
                     /locus_tag="KR257_002531"
     CDS             18553..19062
                     /locus_tag="KR257_002531"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009528606.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="translation initiation factor IF-3"
                     /protein_id="HBH0031213.1"
                     /translation="MSKELAINEQIKDKEIRVLSPTGEQLGVMPTKEAQAMANSKNLD
                     LVQISPNANPPVCKIMDYGKFRYEQARKEKEAKKKQKTIVVKEVRLRPGIEQNDLNTK
                     ANNAIKFLKKGDKVKVELRFRGRELGHKDIGKEVMLKFLDIIKEFGEPTKAPAFEGNN
                     MVVIIDPKK"
     gene            19090..19284
                     /gene="rpmI"
                     /locus_tag="KR257_002532"
     CDS             19090..19284
                     /gene="rpmI"
                     /locus_tag="KR257_002532"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011721840.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L35"
                     /protein_id="HBH0031214.1"
                     /translation="MPKMKTHRGAAKRLKKTGTGKLKRAKAFKKHILTKKSAKTKMNL
                     RKSTLVSDGDAKRIAQLLPY"
     gene            19340..19696
                     /gene="rplT"
                     /locus_tag="KR257_002533"
     CDS             19340..19696
                     /gene="rplT"
                     /locus_tag="KR257_002533"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423569.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L20"
                     /protein_id="HBH0031215.1"
                     /translation="MARVKKAMNARKKHKKILKLAKGFRGSRSKLYRPANTFVMKALK
                     NAYIGRKLKKRDFRKLWIQRINAAARMNGISYSRLMNGLKLSGIEVNRKMLSEMAIQD
                     PEGFAKLAEVAKAKLA"
     gene            20006..20551
                     /locus_tag="KR257_002534"
     CDS             20006..20551
                     /locus_tag="KR257_002534"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895726.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0031216.1"
                     /translation="MNEKLMDCFVNPIKCKLLIEIFSNNRTTAKQLGEKFQDISKATL
                     YRYLNKMLKDDIIKVVEENKIRGTVEKVYAMKLDIADDVNKIIDENSGEEYAQLFTQY
                     MMGFLREFYEYAERKEKDILKDGSGFSVCPVYASIDEIVEVSKKIASILEPLRNNSHE
                     EGRRMHSIGVIITPPKEDEGK"
     gene            20538..20702
                     /locus_tag="KR257_002535"
     CDS             20538..20702
                     /locus_tag="KR257_002535"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0031217.1"
                     /translation="MKGNKSDLHEVEPIYTENRFMIYICIQSKVSLLGLYFIVSFHLS
                     NDLEWYNEVF"
     gene            20991..22916
                     /locus_tag="KR257_002536"
     CDS             20991..22916
                     /locus_tag="KR257_002536"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888496.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="metallophosphoesterase"
                     /protein_id="HBH0031218.1"
                     /translation="MKIKFVIMPLVIFLMVLFVGCQSTKDTEVKAKYTEIKILGTGDL
                     HSILTDSMVSYVNEEREKNKNLLMVDAGDFYGTQSREMWEWSSGKKLINIKRNGRAEY
                     DDIIKSSKDEVPIVKDMAKLKYDAVVLGDNEFVSNDKQSLDKLVSDFKNNNMPLVSAN
                     IYEQSGENYVQPYVMKNIKTDEGNVKVGILGLTIKEVGETLGLEDFEKDKKARELGEQ
                     ADYKGKLYANDLVEDAKKWIKVMEKESPDIIVAVVHSGEEPKTDRNPGNRIKELATTV
                     DGIDAIVAGHTHEKIDEHKYKNKSGDEVIVTQPGWHGDRVSEINFKLNKENGKWDIKE
                     KSSKLKIIDKEVSIVATADLHSHFSDKLTVDLVNERSNPIEPVVVDAGDFLDPQTDEM
                     TQWYKEWKSIRDNNSDKTISRCPMVMDMNQGMYDAVVLGNHEFVSEKDEFWSDERLLD
                     AVIEDFEQVAISVLSANIYRQSGKNYVKPYIIKDVETSEGNVKVGILGLTIKEVGKGL
                     KNVNLQEQFQYKDKLYANDLVEDAKKWVKVMKKKKPDIIVAVVHSGEEPKNPKHPGNR
                     IKELATTVDGIDAIVASHTHEKIDEHEYKNKSGEKVIVTQPGEHGKYYSKITFKVNKE
                     KGSWIINDKFSKTIEVE"
     gene            23317..25221
                     /locus_tag="KR257_002537"
     CDS             23317..25221
                     /locus_tag="KR257_002537"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902100.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="metallophosphoesterase"
                     /protein_id="HBH0031219.1"
                     /translation="MKIKFIIVASIIFLIVLLVGCQSTKDTEINVLATSDLHSIIPDN
                     LISYVEEERKYDENLLMVDAGDFFDMQSGEMNKWFTGQKLVRFKDGIPEYKKIAEPRE
                     GEVPLAKKMAKLKYDAVTFGNHEFVSNDKQSLDKLVSDFKNNNIPLVSANVYEQSGEN
                     YVKPYVMKNINTDKGTVKVGILGLTIKEVGERSRFKSFEQDKKARELGEQPQYKGKLY
                     ANDLVEDANKWVKVMEKKEKPDIIVAIVHSGEEPKNPKNPGNRIKELATTVEGIDAIV
                     AGHTHEKIEQHTYKNNSGEEVIVTQPGAHGNSISKINFKLDKKNDKWFIKDKYSELKI
                     FGKEVNIITTSSLNPKFSDEMAVNLFNERDRDVQPIFIDTGDFLNTNTKEMTKWAKEW
                     QYNENKGIYKKINEWPIVYLGYDAVVLGSHEFTEDKETFEEKKSTLDYIIENFEEMKI
                     PVLSANIYDESGENYVKPYIIHNVETREGNIKVGVLGLTTTDKDEEDLSSSSLSKDSK
                     TSKIPEETGKLYTNNLVKDASEWVKVMQKESPDVIVAVVHSDNNSTLKNPSSEVKKLA
                     MSVDGIDAIVVGHTKNKVEEHIYKNKSGDEVIVTQSGEDCYSKISLELRKENGKWNII
                     NKYSKAIKMK"
BASE COUNT         9933 a         2604 c         4430 g         8469 t
ORIGIN      
        1 gtaagtatat tattatagtt atttatttaa agtacgataa atgttttaaa ttgaagtatt
       61 ttgcgccatt gagttctact aaagtagagt ttttgtgtag tatttttaga aataacatat
      121 atatatatgt atttatgttg aaatatatgg gaaatttata atataattaa tgaaaaaatt
      181 taaactttgt aatatataaa taaaaaaact ctaaaataga aggatataat tatatagaat
      241 gtttcaatta aacaaggcaa aaactataat cttaaaatta acattattct taagaagtaa
      301 gaaatttaag aagtaaaaag tttagttata agtggtagta agcaagaaat ttaagaagta
      361 aaaagtttag ttataagtgg tagtaagcaa gaaatttagg aagtgggaag tttagttata
      421 agtggtagta agtaagaaat ttaggaagtg ggaagtttag ttataagtag tagtaagtaa
      481 gaaatttagg aagtgggaag tttagttata agtagtagta agtaagaaat ttaggaagta
      541 ggaagtttag taataatttg tagcaagtaa gaaacttagg aagtgggaag tttagtagta
      601 ataatttata gcaagtaaga aatttaggaa gtaggaagtt tagtaataat ttgtagcaag
      661 taagaaattt agaaagtagg aagtttagta ataatttata gcaagtaaga aatttaggga
      721 gtaggaagtt tagtaataat ttatagcaag taagaaattt agggagtagg aagtttagta
      781 ataatttgta tcaagtaaga aatttaggga gtaggaagtt tagtaataat ttatagcaag
      841 taagaaattt agaaagtagg aagtttagta ataatttata gcaagtaaga aatttagaaa
      901 gtaggaagtt tagtagtaat ttatagtaag taagaaattt agtaagtgag aagtttagtt
      961 ataatttata gtaagtaaga aatttagtaa gtgagaagtt cagtaataag ttgtagtaaa
     1021 taaaaagttt aggaagtagg aagttcagta ataagttgta gtaaataaaa aatttaggaa
     1081 gtaggattta ctgaaataca aatatttaaa atcaaagagt ttaaaagaaa ggagagctac
     1141 tggacaagta tccaaaatag atagctgagt acaaaatatt tcataaaatt aagcaatata
     1201 atacaagaga attttgacat tatttatata tatttaccgt gtacaaatag ctaaatttag
     1261 gattaagatt gaaaaatatc ttataagtct gagcttatat aaatccgtat aagatgtatt
     1321 taatcgaaaa attttattat ggatattgct tgtctatatt ctgagtagca aggttttatc
     1381 atgactataa aaaagttgcc acaatcagaa ttaaagataa tgaaatttat atggaaatca
     1441 gattccaaag taacatctag agatattgtt ttaggaatgg agcaaaaata tcaatggaaa
     1501 caaacgacaa ctttgactct tttatctaga ttagtagtaa aaagatttct aaattctcaa
     1561 aagatagata aatatacgca ttatgaagtt ttaattaaag aaaaggaata cataggagtt
     1621 gagacaagag atttttttag aaatattcat gattcttcta taaaaagttt attgttgtca
     1681 ttacatgaaa atattaattt gagcaaagat gatatcttac ttattgaaga gtggataaaa
     1741 aatctaaaag aagaggagaa agacgtataa gcaaacgtat ttcttatagc atcaatataa
     1801 agtgtatgta agtgtattta tgtaatatat tagtctactt aagtaatatg acaaatgatt
     1861 ataagtggat tatgatacta taatgtgaat ctaaataaat taaataaaaa ttaatagtgg
     1921 atattctatt taattaaatt taaaaagcta cctttactta taagtataat taaggtagct
     1981 ttttaaatag aggtagtgta attaaagaga atttttaaat ataaattgtg aagctttaat
     2041 atagatgata atatatattt tgcaaatatg acacagtgtt ttcgtattta agatgataaa
     2101 ataaatagga attaatgatg atattgaaaa aataaaaata aaggattaat ataagatatt
     2161 aaagagatag agataaaagt gttaacagaa gatattgaaa aaataaaaga ttgatataag
     2221 atactgaaga ggtagaaaca aaagtattaa tagaagatat tgaaaaaata aaaacaaaag
     2281 attgatagaa agtactgaat agatagagat aaaagtgtta atagaagata ttgaaaaaat
     2341 aaaagattga tataagatac tgaagaggta gaaacaaaag tgttaataga agatactaaa
     2401 aaagtaaaaa taaaggatta ataaaaggta ctgaagagat agagaaaaaa atgttaatag
     2461 aagatactga aaaaatagaa ataaaaaatt aggaggaaaa tttatgaaat atcaggtttc
     2521 attattagca gtgaaggata ttgaagtatc aaaaaaattt tacaaagaat tatttgagca
     2581 agaaattgaa ttggacttag gtaaaaatgt aacatttaaa ggaggatttg ctatacaaga
     2641 agacttcgca tggcttacag ggattaatcc agatacaatt atacaaaaat caaataatat
     2701 ggaactttat tttgaggttg atgattttga cgaatttatt gaaaaactca attattataa
     2761 agatgtagag tttgtccata agccactaaa acatgaatgg caacaaagag tagtgcgtat
     2821 ttatgacccg gataagcata ttattgagat aggagagtct atggaagtta tagctagaag
     2881 atatttatct gagggatact ctgtagaaga aacttctaaa ataattcaac atccaattaa
     2941 atttgtaaag cagtgtgaaa atagtaagga atgattgttt aaattataat tatttagtag
     3001 aaattaattg taatagaact aattcaagat aatatatagg actagtattt gacaaatgtc
     3061 ataaattaaa ttaaaataaa gaaaatatta ataaagaaaa aataaataaa aataagggga
     3121 atattaataa agaaaaaata aatataatat taaaatatat taataaattt gaatatttat
     3181 aatattttta atttgaagta ggaatactta aacgtataaa gtttattatc ggaaatttct
     3241 atattaatat gtagtaattc aatattatta taaaggagtg gttattatta aggcaattga
     3301 actttataaa aaattagatt tagaatttaa tattaaaaat attaatgatg attggagttt
     3361 tatgaatttt gaaaatgatt ttattactcc agaatttaga aaaaaataca taggattagt
     3421 attagataat gctcaaaata ttaataaagt atacacaact acttttcctg ataaagaaat
     3481 aattaagcaa gttatagata aagatgaaaa agatatttta attttttcac atcatgcaat
     3541 gggatacata gcatcagatg aaggttttcc atttcacgac ataccactat cttatatgga
     3601 agagatgaaa aatcgtagaa tttcttttta tgtattacat tctccactag acaactatag
     3661 tgactattca acttctgtta gttttgcaaa agctatgggt ttagaaatag tcaaaccatt
     3721 ttgtaaatat gacgataaaa ttgaagtagg agttatatgt aaaacatcac taaaatcaat
     3781 agaagagatt aaggaattaa ttaaaaaatc tgttggtcat gatgtgaaat tgtatgatta
     3841 tggagattct gtattaaaag atggtttagt tgctattgca gcagggggag gaagttatcc
     3901 atttgtagca agagaagttg ctgaacttgg tataaatcta tatattactg ggtttactaa
     3961 gcctttaaaa cattttgaac cagtattaga gttccatcaa atagcaaaag ataatttaat
     4021 taatgttata ggtgctactc attattctac agaaaaattt gcgtgtatgg gcatggtcga
     4081 ttattttaaa aatctaggtt tagaatcaga atttttgcaa ggaaagtatt acttagagga
     4141 tttataggac atattaaaca ataaaaataa acagttagta aaaatttatt ttactaactg
     4201 tttatttttt tacctattta tccagtgttt tgaaaaaatc tatctttatt ttttaaacta
     4261 agaaaataga cttttaattg ctgattagaa gatttagttt tgatgtcttt taaattattt
     4321 ttcgatattt tttagtttat tttttgatgt attttagatt attatttagg attgattaga
     4381 atttataaat atttatttta gattattata aatatttatt ttaaaaaaat agaattatta
     4441 tatttatgat aataaatggt ataataaaag gtaaagtgtc aaatatgcac taaattaaat
     4501 aagttaatta gtatataggt taaagtggaa gtaattaaaa cttattaagt attagaaaat
     4561 gacttcttat tagagtaagt atctaaaatg atataaaaat tatgattact cattaaagtg
     4621 actattatag agtggataag attactcatt aaagcgatta ctgtggagta gataaaatta
     4681 ctcactaaaa taactatcat agagtggata agattactca ttaaagcgat tactgtagag
     4741 tagataaaat tactcactaa aataattatc atagagtgga taagattact cattaaagcg
     4801 attgctgtgg agtagataaa attactcact aaaataacta tcacagtaga taagattatt
     4861 cattaaagtt actatcacag agtggataaa attacacatt aaaattgtct gttaaagaat
     4921 gaataaaaaa gagattgctc aatataagaa gcatataaaa aataaaaaat caaacgtata
     4981 aaatttaata aataataact gatagggaaa ggaaagatag aatgatattt acaaaaagta
     5041 ataaatacga taaggacttt ctcatgaaaa atatgatggg acctaattgt ataaaaatat
     5101 tggaagaatt aacaagtaag ataaaactag aaaagggaat gcgtatttta gacttaggtt
     5161 gtggtaaagg tatatcttcg atatttttag caaaggaatt tgatgctact gtatttgcaa
     5221 cagatttatg gatagaacca actgaaaact ataaaagatt taaagagttt aaattggatg
     5281 ataaaatatt tccaatacag gcagaggcac atgaactacc ttatgcagaa ggtttctttg
     5341 atgcggtgat aagtatcgat tcttatcact attttggaaa caaagaagga tttttagaca
     5401 atcatatatc acctcttgta aaagaggggg gaatacttgc tatggcaatg cctggattaa
     5461 aagaagattt cgtggattgt ataccagatg aactcattcc attttggcaa gataatatga
     5521 acttccattc aattacatgg tggaataaac tttggtctga atcggagtct gtgattgtag
     5581 agaaatgtga agctttaaat tgtcatgatg aagcttggaa ggattggata aattgtgata
     5641 attcatatgc tataaatgac aaaaaaatga tggaagtaga gaatggaaag tattttaata
     5701 caatttcttt gatagcgaga actaaataat tgtgatgaat ttataaaagt ataagataag
     5761 tagaaatata agttgaatga gagtataaga agcatagaaa tataagttga attaaagtag
     5821 aaggtaaata aaaatgtaag ttaaataaag agtttataca aaaatgattt tttagattat
     5881 ttatacccaa tcgagttgct taggtcagtt gggtattttt attttttaaa gttaaattgc
     5941 aaatactatt gtgtgatata tattttaata ctaaatgttt gttttataag aaataaacta
     6001 atagaaaaaa tagttttaac aatgaaagca aaaaaggtat tgatgaagat taaaaatttt
     6061 atagtaccat tttatatatt ttattatact ttaaatcaaa tttcaaaatg attaagtata
     6121 tatacccaaa agattaaaga actatattta ttatactatt aaaaattatt ttaatagaga
     6181 tacaagagat agatatattg gttttaattt tatagaaata tacaaagata ttttaagcta
     6241 atatatagta atttatatag cattataaaa tagaatcata taaaataagt taactacaat
     6301 caaaaattaa aaaggggaaa tgttaagttg atagaaggca taaaatttat aaaggcagaa
     6361 gaaaagtata tttattcgta ttggcaaact tttgataaaa tagcaaaaga gaggaaatat
     6421 ctagctatgg atgaagcctt tccttttgaa gaaacagttg aatttataaa aaatattata
     6481 aataaaaact taccacaact gtttataatt gatttagaat cagataactg tattggttgg
     6541 tgtgacgttt tacctaaaac tgaaaaagtt ggttatttag gcatgggtat tcttaaagag
     6601 tatagggaaa aaggtatcgg aagtaatctt ttaaaacaaa ttattgattt atcaaaagaa
     6661 tatgggtatg aaaaaattga gcttgatgta tttaaaagta atagtagagc tattcatgtt
     6721 tataaatctt tagggtttgt agaggtaaat acaatatcta gtggttttac atggaatgat
     6781 agacctgtaa aagaagaagt aattcaaatg gagcttacac ttatataaaa taaagttaaa
     6841 gtctttaaaa ttccatatac acttgtataa aataaagtta aagcccttaa aattccatat
     6901 aaaagaaata tttttaaggg ctttttaata atgcttcttt tgaaggtagc taaatatcta
     6961 aaattttata tattaaattt aaagaaaata taaagatgga agatacaacc atgtttacta
     7021 ataaaaaaat taaagtcata aataataaac tcataaacaa cttattatta cttatgttta
     7081 ttttgcatct attacttcat gagccatttt aactaagtca ttcatagata aatttgagtc
     7141 ttgaactgta aaagaatagt aaactccatc ttgtttccat gtcaaaaact taaatttatt
     7201 aacttcaact ttgtctgatt cattatttgg ccctacacta aatgtgtatt tgcctgattt
     7261 ttcatcaatt ttatcctgtt ctgtcatttt ataaccttct ggtacaaact tttgtgcgaa
     7321 tgcttcataa gaaatattaa tatctttgta agtatctaca acttttagat tgtcagaact
     7381 cttcccaagt acattatttg ctgtgtcaag agatatttca tcattgccat ttttatattc
     7441 aaaactaagt gcttttgatt ttcctaaaac attattttct ttgtcaaatg cttttttatt
     7501 tacagtatat gctcctttaa atttatatcc attactaaat tcagaaacta tattaggggt
     7561 aaagttaaag tcttttttta cttgttctgt agttgggata gatgtatagg tagccttagt
     7621 acttgatttt ccaaccaaac tatatatatg tcctactgca agggctgttg tgctcaatat
     7681 caaagtaatg gctaaagttg caactaagcc ttttctaaat ggtaatttgt gtgttttatt
     7741 attaatcatt ttataatttt cctctctttc tggtaaacta tttagtgttt tgcttaaact
     7801 attatgaaaa ctttctggaa cttctggaaa cgaattattt aatatatttt tattcatatg
     7861 attacctccg tgttttctaa tttagttttt aataatcttc ttcctcttga taatctactt
     7921 tttacagttc cttgaggtat atctaatatt tccttaactt catctactga ataaccttca
     7981 atatagtaaa ggactattgg aattttaatt tttttaggta gactttgaat agcagtatac
     8041 aaatcgctat agtcatcttt ttcatcaatt tttttgtttt tgaagacatc ttcaaatgat
     8101 agagatttta atcgtttgcg tcttaatgaa ttacattcat ttatgactat tctaatcagc
     8161 catgttttaa agtattgttc ttccttaaga gaatccaact tttcatatgc ttttaaaata
     8221 gcattgttga cggcatcttc acagtcttgg tcgtttccta gaatagactt agatactcga
     8281 tacaaagtct gttctgattc aagtatattg tttgtaaatg tagttttatc caactaagtt
     8341 ccttcccttc tatgcaaatc gtagcgctac ttttttgtct ttcacttatt agataaaatt
     8401 ttactataga tggttcactt tttttatgat tatttgataa atttaagttt gaaagttttg
     8461 cctattctat acaaatattc tataatatat tttttctagt attttcccct catatataaa
     8521 gccatgtaga tatattaaac tttagaagcc atttatatat ttagttttat agtaagtctt
     8581 tatattgagt aattagaaaa tagtaagtat ttaatgttga gtagttagaa taacaatgct
     8641 tttggattat ttacttcatg tacagattta aaataagttc tttaaatagc aactttttga
     8701 aaaaacgcaa aaatatttta tgttgtctga ttatatttat agatgtgaaa caatattgta
     8761 tagagtaaaa gtatatagaa gatgattaca tagagtttat acttgaattt tacaaatata
     8821 attatcaaaa tactgtcaaa gagaaaaata gttttgatga acgtttttat caaattgcta
     8881 cagagacagg gctaagtgct aatactgtat ataaagtatt caataaaata ataaatagtg
     8941 gaaaaactga atttacatca aaggaattag ctactatatg tggtgtaagt attagaacta
     9001 tggacaggat tatacttaga ttgtgtgatt ctggttattg tgaggtagtg agtgaacagc
     9061 ttatgagcaa gtatggtaga cccagtagaa tattacgttt taaacctttt ctgttgtttt
     9121 aaatagatat aagtcaaaaa ttaaattttt atgataacat tttctttaca attttttaga
     9181 tatatgttaa tatttagaaa aatgcatatg tattcataaa ataaacttaa aacagctaaa
     9241 aaatcattaa aaaggaaatt gtatgcatga aatgagaaag ttaatttata acttaaataa
     9301 atctgggagg agataattat gggaaaatat caggattcaa aaaaagttgt aagaaattat
     9361 tttgaagcat tagaaaatgc tactggggat gaggttgaaa atgtcttaaa gcaacatatg
     9421 aaatcagatt ataactggaa aggtgtgtat ccatttcgtg aacaagaagg cactgaaaat
     9481 gtagcagatg tattttggaa gcctttaaaa aaatcattga gtaatatgca aagacgacaa
     9541 gatattttca ttgcaggaac aaatgagatt gacaatagtg aatgggtaat gagtatgggg
     9601 cattttatgg gactttttga taacgattgg cttggcatta aacatactcg taaaatgatt
     9661 agtttaagat atgcagaatt taactgtgtt caagatggta aaattgctaa aactggatta
     9721 tttgtagata taattgggtt tatgattcaa gcaggagtta atccattgcc accacaaaca
     9781 ggttcatatt ttgtatatcc agggccaatt gaccataatg gattactttt tgaagatgca
     9841 gatgaagttg aaggagtaaa aactttagca ttagtaaata aaatggtaga tgatttatct
     9901 gaattaaatg aaagtggtgc tatgggatgc ccaccagaaa tacttgaaaa atcttgggct
     9961 aaagatatga tttggtatgg tccaggtgga attggtgctt cttatactat acctagatat
    10021 caagagcaac accagctacc atttagaaat aatttaaaag gaaagacttt caatgggcat
    10081 gtatgtagat ttgcagaagg taattttgct tgtttctttg gatggcctaa tctgactaat
    10141 gtaccatgtg gaggtttttt aggattacca ggtggagagg ttaaagcaga tatgcaagtt
    10201 gttgatgttt attatcgtaa gggcgataaa cttcaagaaa actgggtgtt aattgatatt
    10261 ccttattggt tgaaacaaca agggcttgat attcttgaga gaactaaaag tatttttaat
    10321 gcttagttat gcatacgtat tctaaaataa agggggatat aaagtggcat ctaccaacaa
    10381 aaataatgca acaagtaaag aagaagaaaa agaagtttct acaagtgggc ttgaatcatg
    10441 tacggttaaa gaaaacaaag ctaaaatgaa tcaaactaat tttagtaata taaatgaaaa
    10501 tcaaacaaat gagaataaaa cgaacacata taaaagaaat atagataaag gaaatataga
    10561 taaagggaat atagataaaa caaacacaaa taaatccgac ataaataaag ttaacataga
    10621 tacagtggat acagataaat taaatacaaa tactcttact aaaaaaaata aaaaagttat
    10681 atttaagggg gaagataata tgtcatctac aaaaatttac tatggagatt cattagaagt
    10741 aacgcctgtt ggagtaatgg attacaatga tttttcaaaa cagacaaaaa gggaacagga
    10801 aatacctgga tttgattcta agtatagaga ttttgtagat tatattatga agattacaca
    10861 taatatctgg gaagaaaaag gtataggtgt tatttatgat acatatcaca ataatgttac
    10921 aatgcattgt ggctcttcaa atttagttgg tattaaagat gttatttcca atactcttca
    10981 aacattacat gcgtttcctg atagaagatt aattggtcaa aatgtaatat ggtctaactt
    11041 tggtgctgat ggttttttat cttctcaccg tgttttgtct acagcaacta acttaggtga
    11101 tagtaatttt ggaccagcaa caggtagaaa aataaacttt agaactgtaa ttgattgtgc
    11161 cacaactaac aatagaatcc acgaagaatg gttggttaga gataatttat ggattgttac
    11221 tcaattagga ttaaaccctc aggaagtagc aaagagtatg gcaaaggcaa gtgaatctaa
    11281 agtgcttagt ttacaatcaa cttatggtat ctgtgaatct atggatggtc aatttatgcc
    11341 aactaagtat caagcaaaag atgattctgc tggcgaaatg atgcttgaaa tgacaagccg
    11401 tatttataat tataaatata taaatgaagt taaaaaatac tatcatgata atgcagtagt
    11461 acattttata tgtgataaag atttaaatgg ttatgatgag attcaaggaa tgattgtaag
    11521 tttacttgca tcaattccaa atggaagtta tgaagtggaa agagtaactt gtaatcaaag
    11581 agaaaaaaat gaaggttatg atgtatctgt aagatggaga ttacgtggaa taaatgaagg
    11641 tataggattt tttggacagc cttctggaaa gcatatagaa gtaatgggaa tcaatcatta
    11701 tcatatacta caaggtaaag taaaggagga gtggataact tttgatggta tggatgtatt
    11761 aaaacaaatg tatatgggag tagaagaata aagctgttta gagtataaat agttttgaaa
    11821 tatataggga agtattgctt tataaaattt aagtggggaa tgtatatgaa aaatagatgt
    11881 ttaaactttt agcaaaatta tgactaaatt taaaaggggg aattataaaa atatgaaaac
    11941 aacggttgaa atagaaaatg atatcatatt aggaaaagac tattcaaacc taaaaagagg
    12001 aattgcattt ttttcaattg ctttaatata ctttttttat tgctacaatt ttatggtggg
    12061 tacttttatt aaaccaacaa tgatttatgc tttagcagat gggggatttg gtttttcatt
    12121 aaaacaaaca gaagaaatat ttgcagttat gtcttttggt acaattccag gtacatttat
    12181 ttttggggtg atttctacaa aaattgggaa gaagaggact ttaattagcg ttgctttact
    12241 gattggattg acaacattta taccaatgtt atctcctaca aatattatgt tatggaaaat
    12301 agcacgtttg tgtacaggag tagtgttggg aggcgtattt ggaacagcta tgcctttagt
    12361 tgcagatatg tttccaagta aatatcgtgg taagttagct gctatattaa ctgctttatt
    12421 ttcattagca atgatttttg gtgggaaagt atatggcgtt ttaggtgatg caaattggca
    12481 aatattgatg tatactgcga ttataccacc tatagttgga gctatcttag caattttctt
    12541 tgtgccagat gatttggagt atacaaagga attagttaaa aagggaaaag aaactggtga
    12601 aaagattagc tatataagta tgtataaggg aaaatactta tggattggat tgggaacgat
    12661 tcttttatca ggtgcaaatt ttacagcata ttcagcattt tcaaataatg caactacata
    12721 cctagtgaca agaataggaa tgtcagcagc agtggctggg tctatatata gtttacaagg
    12781 aattggtcaa ttagtaggat atttattctg gggttcaatt gcagataaat ttggaagaaa
    12841 aatacctttt ataggtatgg cattagcagc agtatttgtt tttatatata caaaattagg
    12901 tggagataat acaacaacat tctatatgat atcagtatta ctaggtgttg ctgttggata
    12961 ttctggagca tggggagcat actacacaga gttgttccca agtaaatatc gttcgttgtc
    13021 atctggtatg tcatttaatg gaggaaggat tatatctacg tttgcaatac ctgctatagc
    13081 tggtacagct tctggtactt taggtatgat gactatcttt tacatatcaa tcgcagtctt
    13141 tgtagcaggt gctattgtat ggttattctt accggagacg ttaaataata aaaaataaaa
    13201 tactaggaat ttattttgtt acttagaaag gggtggctta tgatttcatc aattgatgta
    13261 tgtattataa taggatattt gctattaatg ttagttattg gttattattc aggaaaagat
    13321 aataaaaatc aagaagatta tttcttggca ggtaggtcaa tgccatggat tccaattgct
    13381 ttatcagttg cagctactat gattagtgca aatggcttta taggtggtcc tggatgggca
    13441 tatgtagatg gaatgtatcc agtaatggtt aatattacag tacctttagc aatatttttt
    13501 gcactgagca ttaccacccc agttatctat aaattaaaaa taacctctat atatgaatat
    13561 atgggacttc gtttaggaaa ttattcaaga ggattaacta ttattcaatt ttttattaat
    13621 tcattgattc aagctagttc tatggtatat attccagtgc ttattattca aatgattact
    13681 ggctggtcac tttatgcttt agtcccaata gttgtacttg tatcaattat atatactcta
    13741 ttaggtggga ttaaggcagt tatatggact gatagtattc aaatgatagt agtaataagt
    13801 gctgtattta tagtaattat tgtagcctta aaaggaatga atctaagttt ctttgataca
    13861 ttacaaattg cacaacagag tggaaaatta aatacatttg atttcagtag ggatatttca
    13921 gtgacaaata ctttttgggc tactttaatt ggtggaactg taatgtggat aagatacttt
    13981 tgttttgacc aatctcaagt acaaagagtt ttaacatcta aatctttaaa atgtgcaaaa
    14041 aattcttttg tagttagtgc atttgttatg aatttagttt actactttat gctattggta
    14101 ggagtaattt tatttgtttt ttatggggga aggacatttg aaacttcaaa tgaaataatg
    14161 attactttta ttttaaatga acttccagta ggagccattg gaattattat tgcaggtgtg
    14221 tttgcagcag caatgtctag tatcgactct atattaaaca gtatgacaac tgtttttacg
    14281 aaggatattt atgagtttta tttcaaaaaa gacaacaaag aatcatcatt aaaagttaca
    14341 atgattataa ctgtagttat aggagttgtt atgacaggtt ttattattat gggatttgga
    14401 ggaagcatca aatcaattct tgaccttgtt ggtaactata tctcatactt tgctggacca
    14461 gctacaggtg catttgtact agcaatgttt acatataaag ctaatgataa aggagtatct
    14521 attggtttta ttgtagggtt agttttagga ttttttattt ctaataaata taatgtgagt
    14581 tggttgtgga atccagcaat aggtgctaca ataacattga tatttggata tatttttagt
    14641 gtcattttaa agaaaaatca taatgcagat gatattaaaa aatacactgc atttggtatg
    14701 agaaatcacc ttatttctca aggaatggat aaagtagatg gagtatctat agtgccattt
    14761 tctttaggta aacaagaact aattgtatta gcttttttta ttatccaata tattatatta
    14821 tttttgatac aattttaaga agaaatacta gatatttaag gagaaatact aaatgaatca
    14881 aaagaaagtt cattataata aatcggctac ctcaaaagat gttgcaagat tggcaggagt
    14941 atctcaatca tctgtttcaa gagcatttgg tagtgcaaat ggaaagggcg taaaacctga
    15001 agtaagagaa agaatttttc gtgtagcaaa cgaaatagga tatgttccta atttggtagc
    15061 acggggaatg attagtggaa aaactaatgt tataggattg atagttggtg atagtctagg
    15121 tccattttac aatagaatta tcaatttatt tgtagaaaaa attcaagaga taggtaaaca
    15181 gtgtctcgtt tttaaagttc ctagacaaca aagtatagat agtataattt caaaagtaat
    15241 tcagtttcaa gtagaagctg tgattattac agcttcggcc atgaataagg tgatggctga
    15301 gacttgtgaa gaaaacaata ttcctgtgat tctttttaat cgttttatac ctggtataaa
    15361 aataagtaca gtctatgtag acccaattga aggtggggga atggctgctg aatatctgct
    15421 taagaaaggt cataagaata taggatatat tcaatttacg agagaaacaa gtgaagaaat
    15481 ggaaaagaaa attggatttt attctaagtt aagacaaagt gggattcata accttaaaga
    15541 agaatctgca aactatgatt atgattctgg atatgaagca ggtaagagaa tgttagcatt
    15601 atcaaatcct ccaacagcaa ttttttgcac aagtgacttg atagctattg gtgtaatgga
    15661 tgctgcaagg tttgagtaca agttgagggt gccagaggat ttatcagtga taggatatga
    15721 tgatattcaa atggcttcat ggaagagtta taatttaacg acgattagac agccactaga
    15781 tttgttgatt gaaaaaacaa ttaacatact taagtcctta ttaaatgaag aaaatccaga
    15841 gtcagttgtt gaaatgttaa aacctgaatt gattgaaaga ggttctacac tttaagtggt
    15901 agatatttaa ttaagtggta gatacctaat taagttgtag atatctgata agaaattttt
    15961 aagttttcaa tcgttctaaa ttgtgagtat aaaaatctac taaatttagt tatgtaaaat
    16021 ataaattata agtgtagaaa ctaggctact agcttttata ccacttcaaa cattactgga
    16081 ggtagttaag tttacatcag tttagtttta tgtagatata atattctgta aatagacaaa
    16141 attaaaatat gtaagtgtct caaaatgaaa tttttagttt atgaggcact tttttgtata
    16201 aaatcaaatg tatttttata actttaacaa taaaaagagg cttatctcta ttttgagaca
    16261 gcctcaaatt tttaaaacta tattagttta cagcttcttt tcctatcaaa tcttttaact
    16321 cttcatgagt catagtttct ttttcaaata agaatttaga aacagaatgt aaatcttcaa
    16381 gattatcctt taacatctct aaagtctctt tataacaaat ttcaactata cgatttgctt
    16441 ccttttgaac cttatcacat aagaaagtct tatcatttcc atcaatagtc ataaatccta
    16501 agttactcat accatattca caaaccattt ggttagctat ttcagtgact ttctttaagt
    16561 cgtcctttgc accagtagat ttatgattaa atattaattc ttctgaagcc tttccagcaa
    16621 gtaatatttt tatttttcca atcaactcat ccttagtata aatatatcta tcttcatcag
    16681 gtaattgaag aacataacct aatgcttgtc ctctaggaac tatagatatt ttttgtatag
    16741 gacaaattcc tactatatca cttacaagag catgtccagc ttcatgatat gctactattt
    16801 ttttctcttt ttcaaccaat gcagagtttt tagattctag ccctgcaata actctttcaa
    16861 gtgccttgtc aaaatgttct gatgtaatac actcactgtc atctctaact gcaaatatag
    16921 ctgcttcatt tgctatattt gaaagatgag ccccattgaa accatgagtt tttttagcta
    16981 aaagttctag atttacagat ttgtctatag gtttgtcatc tgtatgtacc tttagaattt
    17041 caaatctagt gtgatagttt ggtgcaccta tatgaatgtg tctgtcaaat cttcctggtc
    17101 taagtaaagc ttcatctaat aagtcaagtc tattggtagc acctattatt aatacattgg
    17161 aatctttatt aaatccatcc atttcaacta aaagttggtt tagtgtttgg tctttttcgt
    17221 tgttactttc aagatgtctc tttgctccta cagcatctat ttcgtctata aatattatac
    17281 ttggagcttc ttttctagct ttttcaaata gagttctaac tctttttgct cccacaccta
    17341 catatttttc aacgaactct gaaccagtaa cattgaaaaa tgatgagttt gtttcaccag
    17401 ctacagcaga tgcaagtagg gttttacctg ttcctggagg accataaaat aatactcctt
    17461 taggtatttt tgcacccatt ttttgatatt tttgtggtga cttcataaaa tcgactattt
    17521 caaatagttc ttcttttact tcatctaatc cagcaacatc tctaaatgta gtctttggtt
    17581 ttgtagaaag tgaatcatct gtttgattat ctctttccat ttttgtctgt gcaaagacag
    17641 gagctggatt gttgattttc ttaaaaaagt tgtttagcat tttcatattc acacctcagg
    17701 taattaatta ttgttaatca attttatatt ttccatattt actatttttt attatttatt
    17761 tttcatggaa aaaatataca tgttatctaa ataaaaataa atttgtaaga tgtatgaaaa
    17821 aatgaattta tgtatataga gatttctact tatgtattga ataaagtatt acaaattata
    17881 aattatgtat tgattatata ttgagtaaag tattataaag catgtattga ttaagtattg
    17941 aataaaatat tacaaattta gttgaaatga aaatgataaa aaatcttgta ctatatttta
    18001 caaatcatat aaatagagaa attgttgtag cacaaagtag taggtagtat attagaatat
    18061 aatataggat ttgttgtgta gtatagtagc atattagaat ataatatagg atttgttatg
    18121 tagtatagta gtatattaga atacaatata gaatttgttg ggtagtatag tgttatatta
    18181 gaatacaata taggatttgt tatgtagaat atatagagtc atgtagaata taaatatata
    18241 aaaggatttt gggtataaat ttaaaaatta atagcaaaat gagtagtata gacatataat
    18301 tagtagtagg aagtaattaa atttttccta aacaaaaaaa atagttgcaa ataatttgat
    18361 taagtgatat agtagataag gtaagaataa aacaaagaag aagtccgctt ctcaccttac
    18421 gccggaggtt agtaaggtaa atataagtta aagcttaatt ttaatttaag tttgtttaaa
    18481 tttggtaact tatattgcgg atgattacgt catccgcttt ttattttata aaaattttgg
    18541 aggtgtccta caattagcaa agaattagca atcaatgaac aaataaaaga taaggaaata
    18601 agagtccttt caccaacagg tgaacaactt ggagtaatgc ctactaaaga agctcaagca
    18661 atggctaata gcaaaaactt agatttggtt caaatctcgc cgaatgcaaa tccaccagta
    18721 tgtaagataa tggattatgg aaagtttaga tatgagcaag cgagaaaaga gaaagaagct
    18781 aagaaaaaac aaaaaactat agttgtaaaa gaagtaagac ttagaccagg tattgaacaa
    18841 aatgatttaa atacgaaagc taataatgct ataaagttcc ttaaaaaagg ggataaagtc
    18901 aaagttgaac ttagatttag aggaagagaa ttaggacata aagacatagg taaagaagtt
    18961 atgcttaagt ttttagatat aataaaagag tttggagaac caacaaaagc ccctgcattt
    19021 gagggtaata atatggttgt aattatagat ccaaaaaaat agatgattaa ctgagaggag
    19081 gaatttgtca tgcctaaaat gaaaactcat agaggtgcag caaagagatt aaagaaaaca
    19141 ggaactggaa agttaaagag agctaaagct tttaaaaaac atatattaac taaaaaatct
    19201 gcaaaaacta aaatgaactt aagaaaatca actttagtaa gtgatggaga tgctaagaga
    19261 atagcacaat tattaccata ctaagataca gattgtaaat aataactata gaagagggat
    19321 ataaaaggag gtcataacga tggcaagagt taaaaaagct atgaacgctc gtaaaaagca
    19381 taagaaaata ttaaaacttg caaaaggatt cagaggatct agaagcaaat tatatagacc
    19441 agcaaataca ttcgtaatga aagcattaaa aaatgcttat ataggaagaa agttaaagaa
    19501 gagagacttc agaaaacttt ggatacaaag aataaatgca gctgctagaa tgaatggaat
    19561 atcttattca agattaatga atggattaaa attatctggt attgaagtta acagaaaaat
    19621 gttatctgaa atggctatac aagacccaga aggatttgca aaattagcag aagttgctaa
    19681 agcaaaatta gcttagtatt gaatcatgag atgtaaagtc tttgagttat ataaataatt
    19741 caaggacttt tttatttttt gaaaaatact tattagtgtc atgtacaacc aattttataa
    19801 tgataaataa aataagcaat acaatagaat tttatgagat ttattataag aattgttaca
    19861 attatttatg atagctataa aaagtcatag taaaaatgat attgatgtat gttgatatat
    19921 gtataaagct ttcaatcaat cttgaattaa tattatcaac atgataatat tatcttatta
    19981 ataatataaa taagggggag ataatatgaa tgaaaaacta atggattgtt ttgtaaaccc
    20041 aattaaatgc aagttattga ttgaaatttt ttcaaataat cgaactacag ctaaacaatt
    20101 aggagaaaaa tttcaagata tatcaaaggc aacactttat cgttacctta ataaaatgtt
    20161 gaaagatgat attataaaag tagttgaaga aaataaaata aggggaactg ttgaaaaagt
    20221 atatgctatg aagttagata tagctgatga tgtgaacaaa attatagatg agaactctgg
    20281 agaagaatat gctcaactgt ttactcaata tatgatggga tttttaagag aattttatga
    20341 atacgctgaa agaaaggaaa aggatatcct aaaagatggt tcaggatttt ctgtctgtcc
    20401 agtatatgct agtattgatg agatagttga agtgagtaaa aaaattgcta gtatactaga
    20461 acctctaaga aataactcgc acgaagaagg cagaagaatg cattctatag gagtgataat
    20521 cactccacct aaagaggatg aagggaaata aatctgattt acatgaggta gagccaattt
    20581 acacggaaaa tcgttttatg atttacatat gtatccagag caaagtatct ctgcttggat
    20641 tgtacttcat tgtatcattt catctatcta atgacttgga gtggtacaat gaagtttttt
    20701 aatttttcat atcaatgcct aaagaaatga actttagacc acatatgcaa ttaggttaca
    20761 ttatacaatt agaccagata tacaaaataa aaatcagtat ttttatagca gataaattga
    20821 ctgttattct tcttaaaaat catctattag ttattgttag catattgaaa gaaattatag
    20881 gaatctattg aataaatgaa tattgcccat aatcatataa actgctatag tttaaaataa
    20941 agcaggacgt taaattttat agtaatctaa aaatttaaga gggggatttt atgaaaataa
    21001 aatttgttat tatgccattg gtgatatttt taatggtatt atttgtgggg tgtcaaagta
    21061 caaaagatac agaagttaaa gcaaaatata cagaaattaa aatattaggt acaggtgatt
    21121 tgcattcaat tttgacagac tctatggttt catatgtaaa tgaggaaagg gaaaagaata
    21181 aaaatctgct tatggtagat gcgggagatt tctatggtac acaaagtaga gaaatgtggg
    21241 aatggtcttc tggaaaaaag ttaattaata ttaaaagaaa tggtagagca gagtatgatg
    21301 acataattaa gagtagtaaa gatgaagtac ctatagttaa agatatggca aagttgaaat
    21361 atgatgctgt agttttggga gataatgaat ttgtttcaaa tgataagcaa agtcttgata
    21421 aactagtttc tgattttaaa aataataata tgccattggt atcagcaaat atatatgaac
    21481 aatctggaga aaattatgta caaccatatg taatgaaaaa tattaagaca gatgagggca
    21541 atgtaaaagt tggaatacta ggtcttacta taaaagaagt aggggaaacc cttggtcttg
    21601 aggattttga aaaggataaa aaagctagag agcttggaga acaagctgat tacaaaggaa
    21661 aattatatgc aaatgattta gtagaagatg caaagaaatg gataaaagtt atggaaaaag
    21721 aaagtccaga cataatagtt gcagttgtac actcagggga agaacctaaa acagatagaa
    21781 atccaggaaa tagaataaaa gagttagcaa ctacagtgga tggaatagat gcaattgtag
    21841 ctggtcatac tcatgaaaaa atagatgaac acaaatataa aaataaatct ggagatgaag
    21901 taattgttac acaaccaggt tggcatggag atagagtatc agagattaat ttcaaattaa
    21961 ataaagagaa tggaaagtgg gacataaagg aaaagtctag taaattaaaa ataattgata
    22021 aagaagtaag tatagttgct actgcagatt tacattcaca tttctctgat aaattaacag
    22081 ttgaccttgt taatgaacgt agtaacccaa ttgaacctgt tgtagtagat gcaggcgact
    22141 tcttagaccc tcaaacagat gaaatgactc aatggtataa agagtggaaa agtataagag
    22201 ataataatag tgataaaacg attagtagat gcccaatggt catggatatg aatcagggaa
    22261 tgtatgatgc agtagtactt ggaaatcatg aatttgtatc cgaaaaagat gaattttggt
    22321 cagatgaacg ccttttagat gctgttatag aggattttga acaggtggca atttctgtgt
    22381 tatcggcaaa tatatatagg caatctggta aaaattatgt taaaccatat attataaaag
    22441 atgtggagac gagtgaaggt aatgtaaaag taggaatatt gggacttact ataaaagaag
    22501 taggtaaagg tcttaaaaat gtaaacttac aagagcaatt tcaatataag gataaattgt
    22561 atgcaaatga tttagtggaa gatgcaaaga aatgggtaaa agttatgaaa aagaaaaaac
    22621 cagatataat agttgcagtt gtacattcag gagaagaacc aaaaaatcca aaacatccag
    22681 gaaatagaat aaaagaacta gcaactacag tagatggaat agatgcaatt gttgctagtc
    22741 atactcatga aaaaatagat gagcatgaat ataaaaataa gtctggagaa aaagttatag
    22801 tgacacaacc aggtgagcat ggtaaatatt attctaaaat tacctttaaa gtaaataaag
    22861 aaaagggttc gtggattatt aatgataaat tcagtaaaac aattgaggtt gaataacttt
    22921 ataaaattta tagataaagt aaattatctg atattgacat gatatataag ataaagtttc
    22981 taatattagt ataatgcata atgtgaaata ttttaataat aagagaataa acaagacaaa
    23041 taaaaatatt ttaacatgta agatatagta tgaactatta tactaatgct tactttataa
    23101 tttgaacatg ttagaataag tcttatttga aaattttagt gtattagagt aagtattatt
    23161 ttaccagtaa aaaatattga gaactatatg tagatttgct taaaaaggaa tttacatata
    23221 gttcttttcg tataataaat agtacaatct tatatggtaa agataaagtg tgatattaaa
    23281 ttttattatc atccaaaatc taaggaggag tctcttatga aaataaaatt tattatagta
    23341 gcatcaataa tatttttaat agtattactt gtggggtgtc aaagtactaa agacacagaa
    23401 atcaatgtac tcgccacaag tgatttacat tcaattattc cagataattt aatttcctat
    23461 gtagaagagg agagaaaata tgatgagaat ctacttatgg tagatgcagg agattttttt
    23521 gacatgcaaa gtggtgagat gaataagtgg tttactggtc aaaaattagt aagatttaaa
    23581 gatgggatac cagagtacaa aaaaatagct gaaccacgtg aaggagaagt tccattggct
    23641 aaaaaaatgg caaagctgaa gtatgatgca gttacatttg ggaatcatga atttgtatct
    23701 aatgacaagc agagccttga taaattggtt tctgatttta aaaataacaa tataccatta
    23761 gtatcagcaa acgtatatga acaatctgga gaaaactacg taaagccata tgtaatgaaa
    23821 aatataaata ctgacaaggg aactgtaaag gttggtatac ttggtctgac tataaaagaa
    23881 gtaggggaac gttcaaggtt taaaagtttt gaacaagata aaaaggctag agaacttggg
    23941 gaacaacctc aatacaaagg gaaattatat gcaaatgatt tagtagaaga tgcaaataag
    24001 tgggtaaagg ttatggaaaa aaaagaaaag ccagatataa tagttgccat tgtacactca
    24061 ggtgaagagc caaaaaatcc taaaaatcca ggaaatagaa taaaagaact agcaacaact
    24121 gtagagggaa tagatgctat tgtagcaggt catacacatg aaaaaataga acagcataca
    24181 tataaaaata attctggtga agaagtaata gtaacacagc ctggagctca tggtaatagt
    24241 atatcaaaga ttaattttaa gttggataag aagaatgata agtggtttat aaaagacaaa
    24301 tatagtgaat taaagatttt tggaaaggaa gtaaatataa ttacaacttc tagtctgaat
    24361 ccaaaatttt cagatgaaat ggcagttaat ttgtttaatg aaagagatag agatgttcaa
    24421 cctatattta tagatactgg agatttttta aatactaata caaaagaaat gactaagtgg
    24481 gctaaagagt ggcaatacaa tgaaaataaa ggcatctata aaaaaataaa tgaatggcca
    24541 attgtatatc ttggttatga tgctgtagta cttggtagcc atgaatttac agaggataaa
    24601 gagacttttg aggaaaaaaa atctacattg gattatatta tagaaaactt tgaagaaatg
    24661 aagataccag tattatcagc taatatatat gatgaatctg gagaaaatta tgtaaaacct
    24721 tatataattc ataatgtaga aactagggaa ggaaatataa aggttggagt attaggtctt
    24781 actactactg ataaggatga agaagactta agtagctcaa gcttaagcaa agactcaaag
    24841 acttcgaaaa ttcctgaaga aacaggaaag ttatatacta ataatctagt aaaagatgca
    24901 agcgaatggg taaaagttat gcaaaaggaa agtcctgatg tgattgttgc agttgtacat
    24961 tcagataata atagtactct aaaaaatcca agtagtgaag tcaaaaaact tgcaatgtca
    25021 gtagatggaa tagatgctat tgttgtaggt catacgaaaa ataaggtaga agaacatatt
    25081 tacaaaaata agtctgggga tgaggttata gtaacacaat ctggagaaga ttgttattca
    25141 aaaataagtc ttgaactaag aaaagaaaat ggcaagtgga atatcataaa caaatatagt
    25201 aaagcaataa aaatgaagtg aatttattga tatataaacc attattaaca ctgattttta
    25261 taatataata aatactgatt ctataatata attaacacta ctttttataa tgtcatcaac
    25321 actgattcta taatataatt aatactactt ttttaaatat aatcaatact gattccataa
    25381 tataattaac actacttttt taaatataat caatactgat tctacaatat tattaa
//
LOCUS       DAEPID010000055        25013 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.055, whole genome shotgun sequence.
ACCESSION   DAEPID010000055 DAEPID010000000
VERSION     DAEPID010000055.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 25013)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 25013)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..25013
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.055"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            2..1858
                     /locus_tag="KR257_002538"
     CDS             2..1858
                     /locus_tag="KR257_002538"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902631.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PAS domain-containing protein"
                     /protein_id="HBH0031220.1"
                     /translation="MDTHNKYVNFIKNIPVPFLYCRIVKRQEDIEYRVEYISKGMGKV
                     LQLEEGICDKNILDVLPVFKSKKYFKELFSNEVDCIKRYIPTLKNWINIKKQIIGDSY
                     IILYFGKIVFDYRQIIDSFDKKEKVAYIKDEEGIYIDCSENLIPILNNNIKTTKDIFG
                     KNDIEVWGENTGKLFRDDYREGVSSKKRFLQNLFEYEETFFMVEKYFLYDEDELLGTI
                     GIVDNIIYSGYSNRNYNSKDLMKMIEHSIPENMFYKDVYGNYIGFNSGFLNLACMNKE
                     ELLGKNSYKISEEEALIDKIFESDKGVVENKKVVTFELNISMNDENKCIEITKRPFFD
                     SYGSVIGIIGTARDISRRKRLEEEMDKTRMEFFANLSHELRTPINLISSSLQVIEKKE
                     ADLIESNDTLKRNLGIIKQNGNRILRLVNNVIDFTKMQSGYLDFKPEESDIIAFIEEI
                     CMSVADFASQNNIQLTFDTEIEEFSMLFDSEKLERIILNLLSNGIKYNKKDGKINIFL
                     YVKDNVFNMKISDSGIGIPKEKIDKIFNRFEQIDNELSYRVKGSGIGLSLVKSLVELH
                     EGSISLKSQLGIGSEFIVSLPVRSKNNIEKYNHKREISNELSKKLEIEFSDL"
     misc_binding    1941..2181
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00230"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="T-box leader; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /bound_moiety="tRNA"
                     /db_xref="RFAM:RF00230"
     misc_binding    2247..2482
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00230"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="T-box leader; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /bound_moiety="tRNA"
                     /db_xref="RFAM:RF00230"
     gene            2567..3784
                     /locus_tag="KR257_002539"
     CDS             2567..3784
                     /locus_tag="KR257_002539"
                     /EC_number="1.1.1.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420177.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="homoserine dehydrogenase"
                     /protein_id="HBH0031221.1"
                     /translation="MENKVKIGVLGYGVVGSGLIDIIDNNKEKRNIEIVGILVNNLEK
                     HKDKKYSNIITNNIDDIFNKDIDILVEVMGGLEPSLSYIKKALNNKIHVVTANKDLLA
                     ECGDELAKLASENKVSIKFEASVAGGIPVLKPIIESLEGNNIDSINAILNGTTNFILS
                     KMYDENLSYDMALRQAQELGFAEANPESDVLGYDAARKLSILSTLAYDNRVYWKDVYL
                     EGITDIDEKDIEYAKKLNCKIKLIGQSKYENDKVSAFVRPVLVEKDNILARIDNEFNA
                     VIVNGDSVGEVSFVGKGAGSLATGSAVYSDVIDIIDNRVSSIDSFTKDKIQVNKIVRE
                     KCGALLRFKKCNKDEILNIVENCLVKFDILNDDDELAIMVYADSEYEIDNSLCLIKDK
                     GYCEKMNKMLKIS"
     gene            3901..4395
                     /gene="cdeM"
                     /locus_tag="KR257_002540"
     CDS             3901..4395
                     /gene="cdeM"
                     /locus_tag="KR257_002540"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436550.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="exosporium morphogenetic protein CdeM"
                     /protein_id="HBH0031222.1"
                     /translation="MENKKYANGGYSEDWYERGESTAKWFQNDREEYERAAYDEDRER
                     RGSNCGCSDSGENRPRNCERFRREAEIREREAREAFCESSERKKEALAYECEARKLWE
                     EAEKYWDEYSKYNYKGIEYLAEAARLFDEGMECEARRNGNNGGNNNNCCHKCHKCNCN
                     CCRK"
     gene            4660..5925
                     /gene="hisD"
                     /locus_tag="KR257_002541"
     CDS             4660..5925
                     /gene="hisD"
                     /locus_tag="KR257_002541"
                     /EC_number="1.1.1.23"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902633.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="histidinol dehydrogenase"
                     /protein_id="HBH0031223.1"
                     /translation="MKSIKTSSMKEKVDEKILREQVSSIIEDIRNNKDVALKKYNEKF
                     DRNTRDEFRITKEEIKEAYKHVDDEFINNLKIAAKNIREFAKAQKLSFENPFEKEIYP
                     GVILGQTNIPIESCLAYVPGGQYPLFSTALMLIIPAKVAGVKRIVACSPTMKNTEKIN
                     PKTLVAMDIAGADEIYATGGVQAIAAFTYGTEKINPVDIIVGPGNKFVTEAKRQCYGQ
                     VGIDFVAGPSEVLIIADETSNPVYIAADLLAQCEHDLNARGILLTNSLEVAQKVEKNI
                     ESMLKDLPTKDIAYSSWENNGEIILVDDMEEAIKISNFYAPEHLEVAVNEYNDICDRL
                     TNYGSLFIGNLSAEVFGDYVSGTNHTLPTLKASRYTGGVWVGTFIKTCTKQIFNEKAI
                     QSLAPVAEKLAKEEGLYAHAKAAEVRFKK"
     gene            complement(6128..6880)
                     /locus_tag="KR257_002542"
     CDS             complement(6128..6880)
                     /locus_tag="KR257_002542"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861262.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha/beta hydrolase"
                     /protein_id="HBH0031224.1"
                     /translation="MSYFQYQGNSCFYKEYGQGKPIIFLHGNTGSSNMFKALVPLYVE
                     NFRCILIDFLGNGQSDRVSQFSPDIWHDEALQTIALIEHLNCGKVGLIGTSGGAWAAV
                     NTGLERPDLVEAIIADSFDGRTLNDNFIDNLITGREKSKQDIQARKFYEWCHGKDWEN
                     VVNLDTKALLQCANEKRPLFHKELCKLEMPILFTGSKEDEMCRHNLEEEYKQMATFIS
                     KASIHIFSQGGHPAILTNADEFAQLAKVFFKY"
     gene            complement(6998..7267)
                     /locus_tag="KR257_002543"
     CDS             complement(6998..7267)
                     /locus_tag="KR257_002543"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436543.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0031225.1"
                     /translation="MSYQNSIDLLPKELIEQVQEYIDGKVIYIPKKQEHKKHWGENTN
                     TKQVLASRNSQICINFQNGMSIKQLSEKYFLTEKSIQRILKQQNL"
     gene            7742..8836
                     /locus_tag="KR257_002544"
     CDS             7742..8836
                     /locus_tag="KR257_002544"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429999.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ROK family protein"
                     /protein_id="HBH0031226.1"
                     /translation="MKNIVGKPQTIKKVNEDLIKNIIKNEGPITKPEISNITELSLAT
                     VNKIVEQLALKNEVKVSGLSESTGGRRAQLFEINANLEHIIALYYYRNCCIGVVANLL
                     GEIIYQEEFNIRMDTYENVNQDTFFVIDTLIKKEKGNNIRAIGIGVPGVVKKGVVKNI
                     PTIKSWEGINLENLIKSKYNTKVFIENDTNITTIGIYQKQYKDKYKNMALMYLEDGIG
                     SGIVINGELYLGSTNFAGELSYLNIEFGKYNSNNLNLEDYIMSLRKRYLESKDNKFKK
                     EILSIISNFIRTLVCVLNPQAMIIQCSILTKSDMEFIEKDVSNNVGEENFPKLIKVES
                     LREGSINGVISMCLKETDYQYSLSNKKGGY"
     gene            8838..9788
                     /locus_tag="KR257_002545"
     CDS             8838..9788
                     /locus_tag="KR257_002545"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861264.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="N-acetylglucosamine kinase"
                     /protein_id="HBH0031227.1"
                     /translation="MKYLVSIDGGGTKTKFCVSDLDGNILKEHTTGSTNYKSVGIKKT
                     YENINNGFKKILKDLYIDYDDIEYTVFGISGCDSPNDYKIIMDEILKIGINKEKIYLA
                     NDAVLAFYAQADSPGLVIVAGTGSIILGIKEDGEIYRVGGWGYNFSDLGSGYDIGRKL
                     LKKVLLYCDECHEYSDLFSCVLDFFGANSFEQLAYMITDINNNVEIANLASLVIDCAE
                     QGDKLAIEILRESSTELSKLAQVILRKISNPMKVDKSEINIVLSGGTLNKTVYAQMLM
                     NNLKTENTDKNLKFISQENQPVYGGIRLAMALANRRVKHG"
     gene            9781..10965
                     /locus_tag="KR257_002546"
     CDS             9781..10965
                     /locus_tag="KR257_002546"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003433667.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0031228.1"
                     /translation="MDRKKVIVQIFTGGFKAKEIKFNDIKCKLLELLDCIDIEKVIMG
                     WSVDEELYVETKKLLNKYNVELYLWLPCFSEIGLLEKSNLLIDYMGKEVKGYALQEDE
                     NFEFYCPNNKENIKNIKKIYSTYFSDIKFDGIFLDKIRYGSFSNKLNGVFNCFCKDCL
                     NIYEKNNIDKESLMREMNNVSKGVIDNEDTPFGITEYINGKYKFKNKIWEDFFETKNQ
                     NIYKALLEISNYFKSKGLKIGIDTFSPFISYFTGQDLEKLQEVADFIKPMMYRTTKAP
                     AGLPFEFERFIDESIHKNKEIGKRNFLDILGIKEYEGDVYPIEFVLEEIDFMTRNLNK
                     DIYVGVEINKKEIISPVTPKYISENISNINKTTVKGYVLSWDLLSAPKENIDEIIKWF
                     RN"
     gene            10978..12474
                     /locus_tag="KR257_002547"
     CDS             10978..12474
                     /locus_tag="KR257_002547"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902638.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sugar ABC transporter ATP-binding protein"
                     /protein_id="HBH0031229.1"
                     /translation="MSKILEMQQIYKSFGKVDVLKGINFELEKGEVRALLGANGAGKS
                     TLIKILGGVHSQTKGKVILTGNEIMFKNPHHSKENGISIIYQELSLIPTLTVLENIFL
                     GREILKGSVFLNKKDMLEECMKICEDFDFNIDPHMVVSNLSVANQQMVEIMKAVSCNS
                     EIIIMDEPTTSLTNNEKDGLFKIISRLKSKGKTIVYISHILEEVFKVCDSASIMKNGI
                     MIGTYDVEDLTKLKITQLMTGNDNHKLIEKKDYTFAKYEEPPVLEVKNISWSNKIKNV
                     SFKVYRGEVVGLAGLVGSRRTEIINLIFGIDNKDSGDIFINGKKVDITSPKVAIKNKI
                     GLIPEDRKNLGLILEQAIYTNSSSVQIDKFKKFLFIDRNKEIEFSKKGVKELGIKVND
                     VKQEVKELSGGNQQKVVVSKWLEKDLDLIIYDEPTKGIDIAAKEDIFNTIKEFSSKGI
                     GVIFISSDLEEVIRVSDRILVTREGSIVDDLKNENIQVQDIMNSIFNV"
     gene            12497..13447
                     /locus_tag="KR257_002548"
     CDS             12497..13447
                     /locus_tag="KR257_002548"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896747.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBH0031230.1"
                     /translation="MKKAFEKLNLRDYGVLLGFLALCIAISIATPSFLGKQNILNLLR
                     QSSIIGIISAGMTFVIISGNFDISVGAVAALAGAITMKFATGGTNLFASMLLGVAICA
                     VIGLINGIVVAKINVPSLIATMAMVTIVRGLLLMLTGGYPITENIPILDYIGNGYLFN
                     IPIPVVIFFIVVLASFIVLNKTKFGRYVYSVGGNQEASKLNGINVDSHKVKVFIINAV
                     LAGIAGIVLTGRLGTATAIAGEGYDMDAIASVVIGGTSVAGGSGSVLKTVIGVLLMSV
                     INNSFNLLGIDVYFQYIFKGLIILAAVGFDSYSKKKLASR"
     gene            13468..14430
                     /locus_tag="KR257_002549"
     CDS             13468..14430
                     /locus_tag="KR257_002549"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430005.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sugar ABC transporter substrate-binding protein"
                     /protein_id="HBH0031231.1"
                     /translation="MKKLMKHLALLLSLVMIFGLVGCSNGGDKEKNGEKKIAVLLPGS
                     TGYFVATKQGIDAKSKELGVSVEYADAQWDASKQLSQAEDFMAKGVDMIALCGVDSAV
                     SERIVKAANDSDVPIVAFTNSIGSNPTGEFKGLVTYIGQNEEETGALTGKIAKNLLGE
                     TGGKAVLIEGVPGTTPQVLRKKGLEKELKDSNIEIVYNQTSNWEKEQALKVTEDLIQK
                     KTDFNVIICQDDNSATGAGQALKDAGLKDKVKVIGLGGSKDGLKAITDGLIDGTTYMS
                     AVEEGGLVIEKASKFLKGEKIEPVTQIKQVEVNKDNISEFKGEW"
     gene            14802..15434
                     /locus_tag="KR257_002550"
     CDS             14802..15434
                     /locus_tag="KR257_002550"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436524.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YitT family protein"
                     /protein_id="HBH0031232.1"
                     /translation="MARRLFLERIGLIFLGSAILAFGVYNFYYLNNITEGGVLGILLL
                     LKNLFNIQPAIANVVIDGLLLLVGYKFFGKKFLIYSIVASITFSVLYDLFEAIGPLVP
                     QSQNMLLSTILAGVTVGTGVGIVVKAGCASGGDDALALVISKTTSLNIGQVYLATDVI
                     VLLLSLFYLSAFDIFYSLIAVTISGKVIDFIYYHGKSLDMDISNDIVPEC"
     gene            15845..15937
                     /gene="kdpF"
                     /locus_tag="KR257_002551"
     CDS             15845..15937
                     /gene="kdpF"
                     /locus_tag="KR257_002551"
                     /EC_number="7.2.2.6"
                     /inference="COORDINATES: protein motif:HMM:TIGR02115.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="K(+)-transporting ATPase subunit F"
                     /protein_id="HBH0031233.1"
                     /translation="MEGLPMWFLAVVIIMLIIYLVYALINPEKF"
     gene            15978..17660
                     /gene="kdpA"
                     /locus_tag="KR257_002552"
     CDS             15978..17660
                     /gene="kdpA"
                     /locus_tag="KR257_002552"
                     /EC_number="7.2.2.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015391009.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="potassium-transporting ATPase subunit KdpA"
                     /protein_id="HBH0031234.1"
                     /translation="MFMVQIVIVLAIFMILVIPMGKYLYHIATNQKTFGDRLFDKVDN
                     FIYKVCSIDKKKEMNWKQYALALLFTNAVMVFIGYIILRTQSMHIFNPSGIKSMEQGL
                     SFNTIISFMTNTNLQHYSGESGLSYFSQMTVIIYMMFTSAATGYAAAMAFVRGLVGKK
                     KTLGNFYVDLIRITTRVLLPGALIIGLILVTQGVPQTFAGTETVTTIEGKLQDIARGP
                     VAALESIKHLGTNGGGFFGSNSSHPFENPTIISNIVEILSMMILPGACVVAFGHMIKN
                     KKQGWVVFGAMSIIFLIGLVVCFKAESAGNPILSQLGLNQSMGSMEGKEVRFGIAQSS
                     LFTTVTTSFTTGTVNNMHDTLTPLGGLVPLLNMMLNVVFGGKGVGLMNMLMYAIIAVF
                     LCGLMVGRTPEFLTKKIEGKEMKLIALLIILHPLLILMFSGLSVAIPAGLEGISNPGF
                     HGLSQVLYEFASSAANNGSGFEGLGDNTMFWNITTGIVMFFGRYVSIIVLLAISSLLA
                     SKKAVNESIGTLRTDNFTFTIVLVLVVLIVGALTFFPALALGPISEHLVLWH"
     gene            17685..19742
                     /gene="kdpB"
                     /locus_tag="KR257_002553"
     CDS             17685..19742
                     /gene="kdpB"
                     /locus_tag="KR257_002553"
                     /EC_number="7.2.2.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010966942.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="potassium-transporting ATPase subunit KdpB"
                     /protein_id="HBH0031235.1"
                     /translation="METKKTKFITKDIFKTSIIEAFKKLNPKYMMKNPVMFVVEIGFI
                     VTLILTIVPSLFGDEGNNLRAYNGIVTIILFITVLFANFAEAVAEGRGKAQADTLKKT
                     RKDTVARVIDTLGNEKMISASELKLGDIVLVNAGEVIPNDGEVIEGIASVDESAITGE
                     SAPVMRESGGDFASVTGGTTVVSDWLKIRITTKPGESFLDKMIALVEGASRQKTPNEI
                     ALNTLLVGLTLIFMVVLISLYPMANYAGVKIPISTMIALLVCLIPTTIGGLLSAIGIA
                     GMDRVTRFNVIAMSGKAVEACGDVDTMILDKTGTITYGNRLASEFIAVGNADSKDLIN
                     YSVMCSLKDDTPEGKSIVDLGMKLGSTGKTKEAEEAEFVEFSAQTRMSGINLADGRAI
                     RKGAYDSIIKRVKESGGTVPEDLEENVNRVAKLGGTPLVVCVDNEIYGIIYLKDTVKS
                     GLVERFARLREIGIKTIMCTGDNPLTAATIAREAGVDGFIAECKPEDKIDAIKKEQLE
                     GKIVAMTGDGTNDAPALAQADVGLAMNSGTTSAKEAANMVDLDSDPTKILEVVEIGKQ
                     LLITRGALTTFSIANDVAKYFAIIPAIFTLAIPQMEILNVMKLSTSFSAILSALIFNA
                     IIIPCLIPLAMKGVKYRPMKSQAMLMRNMLIFGLGGVIVPFLGIKLIDLLITPLVMVL
                     NLG"
     gene            19761..20387
                     /locus_tag="KR257_002554"
     CDS             19761..20387
                     /locus_tag="KR257_002554"
                     /EC_number="7.2.2.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902640.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="K(+)-transporting ATPase subunit C"
                     /protein_id="HBH0031236.1"
                     /translation="MKTLKPALLVSIVLLVVCGLVYPLVLTGVSQVAFKDKANGSMIE
                     VNGVKVGSELIGQSFTDARFFKGRVSSVNYNTYTKEDLVPDKDGNTSYGGVSSGSFNY
                     GATNPELHDRVQKDIEQFLKDNPTVKREDIPTDLLTASGSGLDPNISPASAKIQIPAI
                     AKASGISESKLQKIVEDNTSKKLFGVLGEDRVNVLKVNVEVAKILGLI"
     gene            20624..21532
                     /gene="cysK"
                     /locus_tag="KR257_002555"
     CDS             20624..21532
                     /gene="cysK"
                     /locus_tag="KR257_002555"
                     /EC_number="2.5.1.47"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902642.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cysteine synthase A"
                     /protein_id="HBH0031237.1"
                     /translation="MLYNNALELIGNTPVVRLNNLGCTNGCSNIYVKLEKVNPAGSIK
                     DRAVYEMLEGLEQRGELKKGDVLVEATSGNTGIALSMIGKLKGYEVVIVMPETMSVER
                     RDLMKAYGANLVLTDGKAGMAGSIEKANELLKENPNYKSLKQFENKDNPNAHYKTTAV
                     EIMNDVKDLDIFVCGVGTGGTLIGTARYLKEQNPNIRVIALEPKKSPAISENKTGPHK
                     IQGIGANFVPENYDSSVVDEVILVDDEDAFDTVKLLAAKEGILVGISSGANIFGAIEM
                     AKKYPDKKIVTVAPDGVDKYMSMGIF"
     gene            21559..22149
                     /gene="cysE"
                     /locus_tag="KR257_002556"
     CDS             21559..22149
                     /gene="cysE"
                     /locus_tag="KR257_002556"
                     /EC_number="2.3.1.30"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009905512.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="serine O-acetyltransferase"
                     /protein_id="HBH0031238.1"
                     /translation="MFKKINKDIEYIMKNDPAARSKIEVFLLYPSVHAMIMHRMAHAL
                     YKKKKLFTARLISQISRFMTGIEIHPGAKMGEGILIDHGMGVVIGETAEVGNRVTIYQ
                     GATLGATGKDTGKRHPTVGDDVLIGAGTKILGPLNIGSNSKIGANSVVVKDVPNGATV
                     VGIPAKIVKIRNLEPVKKNKKEVSYEYDELDNVYYI"
     gene            22309..22497
                     /locus_tag="KR257_002557"
     CDS             22309..22497
                     /locus_tag="KR257_002557"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420199.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ferredoxin"
                     /protein_id="HBH0031239.1"
                     /translation="MKANVNQDTCIGCGLCPSICPEVFDMKDDGKSHVIVDEVPSDAE
                     ESAAEARESCPVDAIDVH"
     gene            complement(22551..23420)
                     /locus_tag="KR257_002558"
     CDS             complement(22551..23420)
                     /locus_tag="KR257_002558"
                     /EC_number="3.4.11.18"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420201.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="methionyl aminopeptidase"
                     /protein_id="HBH0031240.1"
                     /translation="MKLNRNDSCWCGSTKKYKKCHMDMDNKIDSFAKLGHIVPTHDII
                     KNESQIEEIKKSAVINTKILDYISDKIEIGMSTEDINKLVHDFTLQNGAIPAPLDYNG
                     FPKSVCTSVNNEVCHGIPSKDIILKDGDIINVDVSTIFNGYYSDASRMFMIGNVNENA
                     KKLVQVTKECVQKGLEVAKPWGFLGDIGDVINSYAKKNGYSVVREIGGHGVGLSFHED
                     PFVSYVSKKGTEMLLVPGMIFTIEPMVNEGTHEIFVDEENNWTIYTKDGKLSAQWECM
                     VLVTETGVEILTE"
     gene            complement(23617..24861)
                     /locus_tag="KR257_002559"
     CDS             complement(23617..24861)
                     /locus_tag="KR257_002559"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902644.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0031241.1"
                     /translation="MENNLNTAKRNNTELLQNDSLKVNLQIGVDFTLLSKSLKAFYKK
                     EKDFYCIALAPCNVSSEKANRKISIYNMIKEINILIESITDKNELLSEELFTNNLSEF
                     YDESLDEIYIDLKQAYLYIKKNTDSLNIEDSIEYVFDVDISNDIKAKENPLINFNSLS
                     LVVWSGETKHILQQMNILDLEDIHSYSIENNTNITIYENNTLQYKFDEESENIKDSSI
                     DIIEQMLILPDDLNYDKDEVENMKNRLAKINIKYLQTLKEKDIKIKLINSNLTDEPEF
                     SDLKYQLPPCWVRSGKTWKDVPGIYRNNSIVAKIGYSNPSYANVHSSKNLELHETAHA
                     IDKNVLNKKSNSEEFMEVFAQERYKLYDPKQVAHAYISKFIEEFFAESFVHYYLDEDS
                     KNTLKENCPLTYDFLEKLELNY"
BASE COUNT         9611 a         2681 c         4521 g         8200 t
ORIGIN      
        1 tatggatacc cataataaat atgtaaattt tataaaaaat atacctgtac cttttttata
       61 ttgtagaatt gtaaagagac aagaagatat agaatatcga gtagaatata taagtaaggg
      121 tatgggcaaa gtattacaat tagaagaagg tatttgtgat aaaaatatac tagatgtatt
      181 gcctgtattt aagtctaaaa aatatttcaa agagttgttc tcaaatgaag tggattgtat
      241 aaaaaggtac attccgacac ttaaaaactg gataaatata aaaaaacaga taatagggga
      301 ttcatacata attttgtatt ttggtaaaat tgtatttgat tatagacaga taatcgattc
      361 ctttgataaa aaggaaaaag tagcttatat taaagacgaa gaaggcatat atatagattg
      421 tagtgaaaat ttaataccaa tattaaataa caacattaaa acaacgaaag atatctttgg
      481 taaaaatgat atagaagtat ggggagagaa tacaggaaaa ttatttagag atgattatag
      541 agaaggagta tctagtaaaa aaagattttt acaaaatctt tttgaatatg aagaaacatt
      601 ttttatggtt gaaaaatatt ttttgtatga tgaagacgaa cttttaggta ctatagggat
      661 agtagacaat ataatatata gtggttacag taatagaaat tataactcaa aagatttaat
      721 gaagatgata gaacactcaa ttccagagaa tatgttttat aaagatgtgt atggaaatta
      781 tattggattt aattcaggtt ttttgaattt agcttgtatg aataaagaag aattattagg
      841 gaagaatagt tataaaatat cagaagaaga agctttaata gataagatat ttgaaagtga
      901 taagggtgta gttgaaaata aaaaagtagt tacatttgag ttaaatataa gtatgaatga
      961 tgaaaacaag tgtattgaga ttacaaaaag gccgtttttt gatagctatg gaagtgttat
     1021 tggaataatt ggaacagcaa gggatataag tagaagaaaa agattagaag aggaaatgga
     1081 taaaactagg atggaatttt ttgcaaattt atcccatgaa cttagaacgc ctataaattt
     1141 aatatcatct tcattacaag tgatagaaaa aaaagaagca gatttaatag aatcaaatga
     1201 tactttaaaa agaaatctag gtataataaa acaaaatgga aatagaatat tgaggttagt
     1261 aaataatgtt atagacttta caaaaatgca atcaggatat ttagatttta aaccagaaga
     1321 atctgatata attgcattta tagaggagat atgtatgtct gtagctgatt ttgcaagcca
     1381 aaataatata caacttacat ttgatacaga aatagaagaa ttttcaatgt tatttgattc
     1441 agaaaaattg gaaagaataa tattaaattt actttctaat ggaattaagt acaataagaa
     1501 agatggaaaa ataaatatat ttttatatgt gaaagataat gtatttaata tgaaaatatc
     1561 tgatagtggt ataggtatac caaaagaaaa aatagataaa atatttaata ggtttgaaca
     1621 gattgacaat gaactttctt acagagttaa aggaagtggt attggacttt cattagtgaa
     1681 atctttggtt gagttgcatg agggaagtat atctttaaaa agtcaacttg gtattggaag
     1741 tgaatttata gtttcattgc ctgttagaag taaaaataat attgaaaaat ataatcataa
     1801 aagagaaatc agcaatgaac taagtaaaaa attagaaata gagttctcgg atttataagt
     1861 ttaaatataa aaaataaaat tttaaaaaag tattgacaat tgatttagaa gggtttaaaa
     1921 taaattacaa cataataaat aaaaaggcga tgaataggaa gagtaaatct aattcgatta
     1981 ccagagagaa gagtccgttg gctggaagac tttttaaatt agagggattg aaaactacct
     2041 aggagctact ttctgaagtc atctgcatta gtagatttta gtaagaatag tcgttagctg
     2101 cgttaaagtg taaagtgagt tttcatgaca tatgaaaact aaattaggtg gaaccgcggg
     2161 aataatactc tcgtccttat gttataagga tgagagtttt ttgttattta aaaatataaa
     2221 cagtaatcat aataattata gaaaatataa aagcaatgaa taggaagagt aaatttaatt
     2281 cgactatcag agaggaaagt tcacaggctg aaagactttc taagtttgag aaattgaaaa
     2341 ctacctagga gctgtggtct gaagttactt taaaaagttt tagtaagact aaccgttaac
     2401 tgcgttaaag tgtaaagtgg attttatcaa taaatgataa aatcaaattg ggtggaaccg
     2461 cgagtataga ctcgtccctt tatataggga tgagtctatt tttattgcaa taaaagattg
     2521 aaaataaaaa aaaatcggaa aattataaat ttaggaggaa aataaaatgg agaataaagt
     2581 gaaaattgga gtactaggat atggagttgt aggaagtgga cttatagata taatagataa
     2641 taataaagaa aaaagaaata tagaaatagt tggaatttta gttaataatt tggaaaaaca
     2701 taaggataaa aaatattcta atataataac taataatata gatgatatat ttaataaaga
     2761 tatagatata cttgttgaag tcatgggtgg tttagaacca tcattatctt atataaaaaa
     2821 agcattaaac aataaaattc atgttgttac agcaaataaa gatttgttag ctgaatgtgg
     2881 agatgagctt gcaaaattag caagtgaaaa taaagtaagt attaaatttg aagcttcagt
     2941 tgcaggaggt ataccagtat taaaaccaat aatagaatca ctagaaggaa ataatataga
     3001 tagtataaat gcaattttaa atggaactac taattttata ttatctaaaa tgtatgatga
     3061 gaatctatct tatgatatgg cattaagaca agctcaagaa ttaggttttg ctgaagcaaa
     3121 tccagagtca gatgtattag ggtatgatgc tgctagaaaa ctatcaatat tatcaactct
     3181 agcttatgac aatagagtat attggaagga tgtgtattta gaaggaatta cagatataga
     3241 tgaaaaagat attgaatatg caaaaaaatt aaattgtaaa ataaaattga ttggtcaaag
     3301 taagtatgaa aatgataaag taagtgcttt tgttagacct gttttagtag aaaaagataa
     3361 tatccttgct agaatagaca atgagttcaa tgctgtcata gtgaatggag attcagtagg
     3421 agaagtttct tttgtaggta aaggcgctgg aagtttagca acaggaagtg cggtttattc
     3481 agatgttata gatataatag ataatagagt ttcaagtata gattctttta ctaaagataa
     3541 aatacaagtt aataaaatag ttagagaaaa gtgtggagca cttcttagat ttaaaaaatg
     3601 taataaagat gaaattctaa atatagttga gaattgttta gtaaaattcg atattttaaa
     3661 tgatgatgat gaacttgcta ttatggttta tgctgattct gaatatgaaa tagacaacag
     3721 tttatgtcta ataaaagata aaggatactg cgaaaaaatg aataaaatgt tgaaaataag
     3781 ttaaaaaaga aaaaatataa gtttatatgt aacatatttt gacgatttta atactatata
     3841 gtatgagatg aaacaaaaca tctcataaaa aaattaaaat tcaagggaga gatatgttat
     3901 atggaaaata aaaaatatgc aaatggtggt tattcagaag actggtatga aagaggagaa
     3961 tctacagcta aatggttcca gaatgataga gaagaatatg aaagagcagc atacgatgaa
     4021 gatagagaaa gaagaggctc aaactgtgga tgttcagatt caggagaaaa tagacctaga
     4081 aactgtgaaa gatttagaag agaagcagag ataagagaaa gagaagcaag agaagcattc
     4141 tgtgaatctt cagagagaaa gaaagaagca ctagcatatg aatgtgaagc tagaaaatta
     4201 tgggaagaag cagaaaaata ctgggatgaa tattcaaaat acaactataa aggaatcgaa
     4261 tatttagcag aagctgctag attatttgat gaaggtatgg aatgtgaagc tagaagaaat
     4321 ggaaataatg gaggaaacaa taataattgt tgccataaat gccataaatg taattgtaac
     4381 tgctgtagaa aataaaaaaa ttaattgaca aatcaatagt taaaatatat catattatgt
     4441 ataataaaga gaaaattcag aaaaaaataa tgattagaag aaatataagt atatttatta
     4501 gacaaatagt gctcagttag tgaggtgagt acaatatgat taaactccca tcctctagct
     4561 tttgatagag ggtgggagtt tttatttatt tatatatctt aaatgaggat aatattgtaa
     4621 aataaatgag tatgagattg taaaattagg aggtaaaaaa tgaagagtat taaaacatca
     4681 agtatgaaag aaaaggtaga tgaaaagata ttaagagagc aagtaagttc tataatagaa
     4741 gatataagaa ataataagga tgttgcactt aaaaaatata atgagaagtt tgatagaaat
     4801 acaagagatg aatttagaat tactaaggaa gaaataaagg aagcttataa gcatgtagat
     4861 gacgaattta taaataactt aaagattgct gccaaaaata taagagaatt tgctaaagct
     4921 caaaaactaa gttttgaaaa cccttttgaa aaagaaattt atccaggtgt aatcttaggt
     4981 caaactaata ttccaataga gtcatgtctt gcatatgttc caggaggtca gtatccattg
     5041 ttttcaacag ctcttatgct tataatacct gcaaaagtag caggagtaaa aagaatagtg
     5101 gcatgttcac caactatgaa aaatactgaa aagataaatc ctaagacatt ggtagctatg
     5161 gatatagcag gtgctgatga aatatatgca actggaggag ttcaagctat agcagcattt
     5221 acatatggaa cagaaaagat taatccagtt gacataattg taggaccagg aaataagttt
     5281 gtaactgaag ctaaaagaca atgttatgga caagtaggga ttgattttgt cgctgggcca
     5341 agtgaagttc ttataatagc ggatgaaact tcaaatccag tttatattgc agctgattta
     5401 ttagcacaat gtgagcatga tttaaatgca agaggaatat tattgacaaa tagcttggaa
     5461 gtagcacaaa aagttgaaaa aaatatagaa agtatgctaa aagatttgcc aacaaaggac
     5521 atagcatata gttcatggga aaataatgga gagataatat tggttgatga tatggaagaa
     5581 gccattaaaa taagtaattt ttatgcacca gaacatttag aagttgcagt aaatgagtat
     5641 aatgatattt gtgatagatt aactaactat ggttctttat ttattggaaa tctttctgct
     5701 gaggtgtttg gtgactatgt ttcaggtacc aatcatacat taccaacact taaagcatca
     5761 agatatactg gtggtgtttg ggttggaact tttatcaaaa cttgtacaaa gcagatattt
     5821 aatgaaaaag ctatacaatc attagcacct gtagctgaaa agctggcaaa agaagaggga
     5881 ttatatgcac atgcaaaggc tgctgaggtt aggtttaaaa agtagtaaaa aattttattt
     5941 tggcagtcga gatttagtgt tagactgaga taaggaaaac gctgagaacc cgaataaata
     6001 ctatattttg tgggcctcgg cgtttctttt atatctgtat ataataggat aatactacct
     6061 gtgtgtttaa atgctagctt aatatttctt ttctaaataa tgtttatgaa atagttaata
     6121 tttttagtta atacttgaaa aaaacttttg ctaactgtgc aaattcatct gcattcgtca
     6181 atatagcagg gtgtcctccc tgactaaaaa tgtgaatact tgcttttgaa ataaaagttg
     6241 ccatttgttt gtactcttct tcaagattat gacgacacat ttcgtcttcc ttacttcctg
     6301 taaataaaat tggcatttct aatttacaca attctttatg aaacaaaggg cgtttctcgt
     6361 ttgcacattg caatagagct tttgtatcaa gattaacaac attctcccaa tcttttccat
     6421 gacaccattc atagaatttt cgtgcttgaa tatcttgctt tgatttttcc cttccagtga
     6481 ttagattatc tatgaagtta tcattaagag tacgtccatc aaagctatct gctataattg
     6541 cttcaactaa atcgggacgt tctaatccag tattaacagc tgcccatgct cctccacttg
     6601 ttccaattaa gccaacttta ccacaattca aatgttcaat caatgctatt gtctgtaagg
     6661 cttcatcatg ccatatgtca ggagaaaatt gagaaactct atccgactgt ccattaccta
     6721 aaaaatcaat taagatacat ctaaaatttt ctacatataa tggcacaagt gctttaaaca
     6781 tattagaaga accagtatta ccatgcagga aaattatcgg tttaccttgt ccatattctt
     6841 tataaaaaca agaattacct tgatactgaa aatatgacat atattttcct cctttttatt
     6901 tgttaagtta attataacaa tataggtatg aatgaaaaac ctcatgttct ttcttagaat
     6961 aaaaatgtgc cacgcataaa acgtgacaca tttctaatta taaattttgc tgtttaagta
     7021 ttctttgtat gcttttctct gtcaaaaagt atttctctga taactgcttg atactcattc
     7081 cattttggaa atttatacag atttgagaat tacgagaagc taagacttgt ttggtgtttg
     7141 tgttttcacc ccaatgcttt ttgtgctctt gctttttggg aatataaatc actttaccat
     7201 ctatatattc ttgcacttgc tcaatcagtt ctttaggcag taagtcaatc gaattttgat
     7261 agctcatttt gcacctccta aataattatt ctttaggatt agcaaaggct actgccactc
     7321 acaattaaaa ataaaatttt ttattatgta caatagcctt tgctatgcac aagttccaat
     7381 tcccataaac taaatactcc tttctggttt gaaaaattca tctgaacatt gatttcgctt
     7441 ttaagataga gttcaatgac aaatttacat ttttattata tatattcaga tagataattg
     7501 caactgtctt tgtatgagga tattttatta tagtcaatac tataatatgt atttatatca
     7561 tcaaactaat atgaacagtt gaaaggaata tgaacaataa aacttagtca ggaagaataa
     7621 ttatgaagca gacaatagag aaatttgatt ttaaagtttt attgaaaatt tattgacaaa
     7681 tttaacttgt aaatattata ctaaacttaa taaataaagt ttataaagta aggtgttgtc
     7741 tatgaaaaat atagttggaa aaccgcaaac gataaaaaaa gtaaatgaag atttaataaa
     7801 aaatattata aaaaatgaag gtcctataac aaaaccagaa atttcaaaca ttactgaatt
     7861 gagtttagct acagttaata agattgtaga gcaattagct ttgaaaaatg aagttaaagt
     7921 aagtggacta agtgaatcta ctggaggaag aagagctcaa ttatttgaaa taaatgcaaa
     7981 cttagaacac ataatagctt tatattatta tagaaattgt tgtatagggg tagttgccaa
     8041 tttattaggt gaaataattt atcaagaaga atttaatata agaatggata catatgaaaa
     8101 cgttaaccaa gatacttttt ttgttataga tactctaata aaaaaggaaa aaggaaacaa
     8161 tataagggct attggaattg gtgtcccagg agttgtaaaa aaaggtgtag ttaaaaatat
     8221 accaactata aaaagttggg aaggtataaa tttagaaaat ttaataaaga gtaaatacaa
     8281 tactaaagtg tttatagaaa atgatacaaa tattactact attgggattt atcaaaaaca
     8341 gtataaagac aaatataaaa atatggctct tatgtattta gaagatggta ttggttcagg
     8401 tatagttata aatggtgaat tgtatttagg ttctacaaat tttgctggag agttaagtta
     8461 tctaaatata gaatttggta agtataactc taacaactta aatcttgaag attatattat
     8521 gagtttaaga aaaagatatt tagaaagtaa agataataaa tttaagaaag aaattttatc
     8581 tataatatca aactttataa ggactcttgt atgtgtccta aatccacaag ctatgattat
     8641 acagtgtagt atattaacca agagtgacat ggagtttata gaaaaagatg taagcaataa
     8701 tgttggagaa gaaaattttc ctaaattaat aaaagtagag tcattgagag aaggaagtat
     8761 aaatggagta attagtatgt gtttaaaaga aactgactat caatattcct tatctaataa
     8821 aaaaggagga tattaatgtg aaatatttgg tttcaataga tggaggggga acaaaaacta
     8881 aattttgtgt aagtgactta gatggaaaca tacttaaaga acataccact ggttcaacta
     8941 attataagtc agttggaatt aaaaaaacat atgaaaatat taataatgga tttaaaaaaa
     9001 tattaaaaga tttatatatc gattatgacg atattgagta cactgtattt ggtatatctg
     9061 gttgtgattc tcctaatgat tataagatta taatggatga aatattaaaa attgggatta
     9121 acaaagaaaa aatatatctg gcaaatgatg cagttttagc tttttatgca caagcggatt
     9181 cccctggttt agtaattgtg gctgggacag gttcaattat actgggaatt aaagaagatg
     9241 gagaaatata tagagttggt ggatgggggt ataattttag tgatttgggt tctggatatg
     9301 atatagggag aaaattatta aagaaagtat tgctttattg tgatgaatgt catgagtata
     9361 gtgatttatt tagttgtgtc ttggatttct ttggagcaaa tagttttgaa caacttgcat
     9421 atatgattac tgatataaac aataatgttg aaatagcaaa cttagcttca ttagtgattg
     9481 attgtgccga acaaggtgat aaattggcta ttgaaatatt aagagaatca tcaactgaac
     9541 tatctaaatt agctcaagta atattgagaa aaatatctaa tccaatgaaa gtggataaaa
     9601 gcgaaataaa tatagttttg tctggtggta cattaaataa aactgtatat gctcaaatgt
     9661 taatgaataa tttaaaaaca gaaaatacag ataaaaattt aaaatttata tctcaagaaa
     9721 atcagccagt gtatgggggg ataagacttg ctatggcatt agctaatagg agggtcaagc
     9781 atggatagaa aaaaggtaat agtacaaatt tttactggag gttttaaggc taaagaaata
     9841 aagtttaatg atataaaatg taaactacta gaattattgg actgtattga tatagaaaag
     9901 gttatcatgg gatggagtgt agatgaagaa ttatatgtag aaactaaaaa actattaaat
     9961 aaatataatg ttgaactata tctttggttg ccatgttttt ctgaaatagg attacttgaa
    10021 aaaagtaatt tgctaattga ttatatgggg aaggaagtca agggctatgc tttacaagag
    10081 gatgaaaatt ttgagtttta ttgcccaaat aataaggaaa atataaaaaa tataaagaaa
    10141 atatatagta cttattttag tgatattaaa tttgatggaa tttttttaga taaaataagg
    10201 tatggttctt tttcgaataa actaaatggt gtttttaatt gtttttgtaa agattgttta
    10261 aatatatatg aaaaaaataa tattgataaa gagtcgttaa tgagagaaat gaataatgtg
    10321 tctaagggag ttatagataa tgaagatact ccatttggta taacagaata cattaatgga
    10381 aaatacaaat ttaaaaataa aatatgggaa gatttttttg aaacaaaaaa tcaaaatata
    10441 tacaaggcat tattagagat aagtaattat tttaaaagta agggattgaa aataggtata
    10501 gatacttttt ctccttttat ttcttacttt acaggtcaag atttagaaaa attacaagaa
    10561 gtagcagatt ttataaaacc aatgatgtat agaactacaa aagctccagc tggtttacca
    10621 tttgaatttg aaaggtttat tgatgaatcc atacataaga ataaagagat tggaaaaaga
    10681 aatttcttag atattttagg aattaaggag tatgaaggag atgtatatcc tatagaattt
    10741 gtactagagg aaatcgattt tatgacaaga aatcttaata aagatatata tgtaggagtt
    10801 gaaataaata aaaaggaaat tatatctcct gttacaccta agtacataag tgaaaatatt
    10861 tcaaatataa ataagacaac agtaaaagga tatgttttat cttgggattt gttgtcagca
    10921 ccaaaagaaa atattgatga aattataaaa tggtttcgga attagtgagg tgataaagtg
    10981 agtaagatat tggaaatgca acaaatatat aaaagttttg gaaaggtaga tgttttaaaa
    11041 gggataaatt ttgagttaga aaagggagaa gtaagagctc ttttgggagc taatggagca
    11101 ggaaaatcta cacttattaa aattttagga ggagttcatt ctcaaactaa aggtaaagta
    11161 attttgactg gtaatgaaat aatgtttaaa aatccacatc attctaaaga aaatggtatt
    11221 agtataattt atcaagaatt aagcttgata ccaacgctta cagtacttga aaatattttt
    11281 cttggtagag aaattttaaa aggaagtgtg tttttaaaca agaaagacat gcttgaggaa
    11341 tgtatgaaaa tttgtgagga ttttgatttt aatatagacc cacatatggt agtttctaat
    11401 ttaagtgtag caaaccaaca aatggttgag ataatgaaag ctgtttcatg taattctgaa
    11461 attatcataa tggatgaacc tacaacatca cttactaata atgaaaaaga tgggctattt
    11521 aaaataataa gtagactaaa gtctaaaggt aaaacaatag tctatatttc tcacatatta
    11581 gaggaagttt ttaaagtatg tgatagtgca agtataatga aaaatggaat tatgattgga
    11641 acttatgatg tagaggattt aactaaatta aagataactc aacttatgac aggaaatgat
    11701 aatcacaaac ttattgagaa gaaggattat acatttgcaa aatatgaaga gccaccagta
    11761 ctagaagtaa agaatataag ctggtctaac aaaataaaaa atgtttcatt taaagtttat
    11821 agaggcgaag ttgtaggtct tgcaggtctt gtaggttcaa gaagaactga aattataaat
    11881 ttgatatttg gtatagataa taaagatagt ggagacattt ttatcaatgg taaaaaagta
    11941 gacataactt ctcctaaggt tgctataaaa aacaaaatag gattgattcc tgaagataga
    12001 aaaaatctag gattaatttt agaacaagct atatacacaa actcatcatc agtacaaatt
    12061 gataaattca agaaattctt gtttatagat agaaataaag aaattgagtt ttctaaaaaa
    12121 ggtgttaagg aattaggaat aaaagttaat gatgtaaagc aagaagtaaa agagcttagt
    12181 ggtggaaatc aacaaaaagt agtagtttct aagtggttag agaaagattt agatttaata
    12241 atatatgatg agccgacaaa gggaatagat attgctgcaa aagaagatat tttcaataca
    12301 atcaaagaat tttcaagtaa aggaatagga gtaatattta tatcttctga tttagaagaa
    12361 gtaataagag taagtgatag aattttagta actagagaag gttctattgt agatgattta
    12421 aaaaatgaga atatacaggt tcaagatata atgaacagta tatttaatgt ataaaaaatg
    12481 aaaatggagg actgaaatga agaaagcttt tgagaagtta aatttaagag attatggagt
    12541 attattaggt tttttagctt tatgtatagc tataagtatt gcaactccat catttttagg
    12601 taaacaaaat atacttaatc ttttacgaca atcttctata attggaataa tttcagcagg
    12661 tatgactttt gttataatat ctggaaactt tgatatatca gttggagcag tagcagctct
    12721 tgcaggtgct ataacaatga aatttgcgac tggtggaact aatttgtttg catccatgct
    12781 cttaggtgta gcgatttgtg cagtaatagg attaatcaat ggtatagtag ttgcaaagat
    12841 aaatgtacca tcattaatag ccactatggc tatggtcact attgtaagag gattgctgtt
    12901 gatgcttaca ggaggatatc caattactga aaatatacca atacttgatt acattggaaa
    12961 tggatatttg tttaatatac caataccagt agtaattttc tttatagtgg tgttagcttc
    13021 atttattgta cttaataaaa ctaagtttgg tagatatgtt tattctgtag gagggaatca
    13081 agaagcaagt aaacttaatg gtataaatgt agattctcac aaagtgaaag tatttattat
    13141 taatgctgta cttgcaggaa tagctggaat cgtactaaca ggaagacttg ggactgcaac
    13201 tgcgattgca ggtgaaggat atgatatgga tgcaattgca tctgtagtaa taggaggtac
    13261 atcagtggca ggaggttctg gttctgtact taaaactgtt ataggagtat tacttatgag
    13321 tgttataaac aacagtttta atcttcttgg aatagatgta tatttccagt acatatttaa
    13381 aggattaata attttagcag cagttggatt tgattcttat agcaagaaaa aacttgcttc
    13441 aagataaaaa ataaggggga tttttttatg aaaaaattaa tgaaacattt agcattgttg
    13501 ctatcacttg ttatgatatt tggtttagtt ggttgttcaa atggtggtga caaagaaaaa
    13561 aatggagaaa agaaaatagc agtattacta ccaggttcaa caggttactt tgtagcaact
    13621 aaacaaggta tagatgcaaa atctaaagaa ttaggtgtaa gcgtggaata tgcagatgct
    13681 caatgggatg ctagtaaaca attatcacaa gctgaagatt ttatggctaa aggggtagac
    13741 atgattgcat tatgtggagt tgattctgct gtaagtgaga gaatagttaa agctgctaat
    13801 gattcagacg ttcctatagt agcatttaca aattctatag gaagtaaccc aactggagaa
    13861 tttaaaggtt tagttacata tataggacaa aatgaggaag aaacaggagc attaactgga
    13921 aaaattgcta aaaacttatt aggagaaact ggtgggaaag ctgtattaat agaaggagta
    13981 ccaggaacta ctccacaagt attaagaaaa aaaggtcttg aaaaagaatt aaaagatagt
    14041 aatatagaaa tagtttataa tcaaacttca aattgggaga aagagcaagc tttaaaggta
    14101 acagaagatt taattcaaaa gaaaactgat tttaatgtta taatatgtca agatgataat
    14161 tctgctacag gtgcaggtca agctttaaaa gatgctggtc ttaaggataa agttaaagtc
    14221 ataggtttgg gtggaagtaa agatggatta aaagctataa ctgatgggtt aatagatggt
    14281 acaacttata tgtctgctgt agaagaaggt ggattagtca tagaaaaggc atctaaattc
    14341 cttaaaggtg aaaaaataga acctgttaca caaattaaac aagttgaagt taacaaagat
    14401 aatatttcag agttcaaggg tgaatggtaa attgtcatag ataataaata agatttttag
    14461 agttacttta gaaactatat aaagtaactc tttttttaat ttaatttagt gataaattat
    14521 tgaatagtat ttctaaacaa ataaaaaatt aatataaaca aagacttaat tatactaaat
    14581 tataagtaaa actaatataa acttatggaa aaaaggaaaa cgtctaaagt attggaatta
    14641 ctatagtgta ggtgtggtat taaaaaaaca taaaaaaaca taaaaaaatt gttgaaaaaa
    14701 atatagaaat tttgtataat taaagatttg aaaagtgcgg tatacaaagc caattctttt
    14761 gtatataata tatataaatt cagaaaaagg aagggatatg tatggccagg cggttatttt
    14821 tagaaaggat tggacttata tttttaggtt cagcaatatt agcatttgga gtttataatt
    14881 tttattattt aaacaacata acagaaggtg gagtgttagg tattttacta ctgttaaaaa
    14941 atttattcaa tatacaacca gcaatagcaa atgttgtaat agatggtttg ctacttttag
    15001 taggatataa atttttcggt aaaaaattcc ttatatattc aatagtagct tctataactt
    15061 tttcagtgtt atatgactta tttgaagcta taggacctct agtaccacaa tcacaaaata
    15121 tgcttttatc aactattttg gcaggtgtaa ctgttggaac tggtgtaggt atagtagtaa
    15181 aagcaggttg tgcatcagga ggagacgatg ctttagcatt agtaatttct aagactacat
    15241 ctttgaacat agggcaagtt tatttagcaa cagatgttat tgtattgttg ttatcattat
    15301 tttatctatc agcgtttgat atcttttatt ctttgattgc tgttacaatt agtggcaagg
    15361 taattgattt tatttattat catggtaaaa gtttggatat ggatataagt aatgatatag
    15421 ttccagaatg ttaatataaa ttaaataact ttagatttta ttaggggtgg cagatttgcc
    15481 accttttttg tgtctaaatc tttatagaaa gtataatcct atctaggttt ttgcaaatct
    15541 caaatataga attatgttga aatgactggg aatacgattg ctagatgtgc attttaaaaa
    15601 cccaatttta tatttatgaa atactaatca ttaatggatg tttcttaatc ctatctttat
    15661 acctaaaatg ataagataaa tgaagtagca atacaaaact aaaatttgta aaagagatta
    15721 aattaaatgg aggagctaaa atgttggata tagttatgat agcattgtta ttcataggat
    15781 ttgtttccat gaagttactt gctgattggt gtgggaaaca aactgaaaaa aaataatgta
    15841 atgtatggag ggattaccta tgtggtttct ggcagttgta attataatgt taataatata
    15901 tttggtatat gcgcttatta atcctgaaaa attttaaaca gtataaggct aataagtaag
    15961 ttgaattggg gggaacaatt tttatggtgc agatagtaat agtgttagcg atttttatga
    16021 ttttagtaat acctatgggc aagtatttat atcatatagc tactaatcaa aaaacatttg
    16081 gagatagact atttgataaa gtggacaatt ttatatataa ggtatgtagt atagataaga
    16141 aaaaagaaat gaactggaaa cagtatgcat tagctttatt atttacaaat gcagttatgg
    16201 tatttatagg atatatcata cttagaactc aaagtatgca tatttttaat ccaagtggaa
    16261 ttaaaagtat ggaacaagga ctatcattta atacaataat aagttttatg acaaatacaa
    16321 atcttcaaca ttattcaggt gaatcaggac tttcatactt tagtcagatg acagtgataa
    16381 tatatatgat gtttacatca gctgcaacag gatatgcggc tgctatggca tttgtaagag
    16441 gtctagtcgg taaaaagaaa acattgggaa atttttatgt agatttaatt aggataacaa
    16501 caagagtact tttaccagga gctttaatta ttgggcttat attagttaca caaggagtac
    16561 cacaaacttt tgctgggaca gaaacagtga ctactataga aggaaagctt caagatatag
    16621 ctagaggtcc tgtggcagct cttgaatcaa taaaacattt aggaacaaat ggtggtggat
    16681 tctttggttc aaattcatca cacccatttg aaaatccaac aataatatca aatatagtag
    16741 aaatattatc tatgatgata ttaccaggag cttgtgttgt tgcatttggt cacatgataa
    16801 agaataaaaa acaaggttgg gttgtgtttg gcgcaatgtc aatcatattt ttaataggtc
    16861 tagtagtgtg ctttaaagca gaaagtgcag gaaatcctat tttatcacaa ttagggctta
    16921 atcaaagtat gggaagtatg gaaggtaagg aagttagatt tggtatagca caatcatcat
    16981 tattcacaac agtgactact tcctttacga caggtacagt taataatatg catgatacac
    17041 tgactccttt aggaggatta gtaccacttt taaatatgat gctaaatgta gtatttggtg
    17101 gtaaaggcgt aggtctgatg aatatgttga tgtacgctat aatagcagta ttcttatgtg
    17161 gattaatggt aggaagaaca ccagagtttt taactaagaa aatcgaagga aaagaaatga
    17221 agcttattgc tttacttatt atattacatc cacttttaat actaatgttc tctggtcttt
    17281 cagtagcaat accagcagga cttgaaggaa tttcaaatcc tggattccat ggattatcac
    17341 aggtattgta tgagtttgca tcttcagcag ccaataatgg ttcaggattt gaaggtctag
    17401 gagataacac tatgttttgg aatataacaa caggtatagt tatgttcttt ggaagatatg
    17461 tgtctattat agtactacta gcaatatcaa gtttgttagc atctaaaaaa gctgtaaatg
    17521 aaagtatagg aacacttaga acggataatt ttacatttac aatagtttta gtacttgttg
    17581 ttttaattgt tggtgcttta acatttttcc cagccttagc gcttggacct atttcggagc
    17641 atctagtgtt gtggcactaa aaaattggga gggagtaaag ttttatggaa actaaaaaaa
    17701 caaagtttat tacaaaagat attttcaaaa cttccattat agaagctttt aaaaaattaa
    17761 atcctaaata tatgatgaaa aatccagtta tgtttgttgt agaaattgga tttatagtaa
    17821 cattgatact tacaatagta cctagtttgt ttggtgatga aggcaataac ttaagagctt
    17881 ataatgggat tgtaacaata atcttattta taacagtcct ttttgcaaat tttgctgaag
    17941 ctgtagctga aggaagaggt aaagctcaag cagatacact taagaaaact agaaaagata
    18001 cagtagcaag ggttatagat acgttaggaa atgaaaaaat gataagtgca agtgagctaa
    18061 aacttggtga tattgtttta gtaaatgctg gagaagttat cccaaatgat ggagaagtta
    18121 tagagggtat agcttctgtg gatgagtcag caataactgg agaatctgca cctgtcatga
    18181 gagaatcagg tggagatttc gcatctgtta caggtggtac tacagttgta agtgactggt
    18241 taaagataag aataacaaca aaaccaggag aatcgttctt agataaaatg atagctcttg
    18301 tagaaggtgc ttcaagacaa aaaacgccaa atgagattgc tttaaatact ttgttagtag
    18361 ggttaacact tatatttatg gttgttttaa tatctcttta tccaatggca aactatgcag
    18421 gtgtaaagat tccaatttct actatgatag ctctcttggt atgtttaata ccaactacta
    18481 taggtggatt gttgtcagct attggtattg caggtatgga tagagtaact agatttaatg
    18541 taattgcaat gtcaggaaaa gcagtagaag cttgtggaga cgttgatact atgattttgg
    18601 ataagacagg tacgattact tatgggaata gacttgcatc agaatttata gcagttggaa
    18661 atgcagattc aaaagattta ataaattatt ctgttatgtg ttcattaaaa gatgatacac
    18721 cagaaggaaa atctatagtt gatttaggta tgaaattagg ttcaacaggt aagacaaaag
    18781 aggcagagga agctgagttt gtagaatttt ctgcacaaac tagaatgagt ggtattaact
    18841 tagctgatgg tagagctata agaaaaggtg cttatgatag cataataaaa agagtaaaag
    18901 aatctggtgg tacagtgcca gaagatttag aagaaaatgt aaatcgagta gctaaactag
    18961 gagggacacc tttagtagtg tgtgtagata atgagatata tggaattatc tacttaaaag
    19021 atacagtaaa atcagggctt gtagaaagat ttgctagact tcgagagata ggaataaaga
    19081 caataatgtg tacaggggat aatcccttga cagcagctac aattgcaaga gaagctggag
    19141 tagatggatt tattgcagaa tgtaaaccag aagataaaat agatgcaata aaaaaagaac
    19201 aattagaggg taaaatagtt gcaatgacag gtgatggaac aaatgatgct cctgcacttg
    19261 ctcaggcaga tgtaggtctt gcaatgaata gtggtacaac atctgcaaaa gaagcagcaa
    19321 atatggtgga tttagattca gacccaacta agatattgga agttgttgaa ataggaaaac
    19381 agcttttaat aactcgtggg gctttgacaa catttagtat agcaaatgat gttgcaaaat
    19441 attttgcgat tataccagct atatttactc ttgcaatacc tcaaatggag atattaaatg
    19501 taatgaaact ttctacgtca tttagtgcga tattatcagc tttaatattt aatgctataa
    19561 ttatcccatg tttaatacct cttgcaatga agggagtaaa atatagacct atgaaatcac
    19621 aagctatgtt aatgagaaat atgcttatat ttggtcttgg tggagttata gtaccatttt
    19681 taggaataaa attaattgat ttattgatta cacctttagt aatggttctt aatttaggtt
    19741 aataaatgga ggatataaaa atgaaaacat taaagccagc attacttgta agtattgtat
    19801 tgttagttgt ttgtggactt gtatatccac ttgttttgac aggtgtaagc caagttgcat
    19861 ttaaagataa agctaatgga agtatgatag aagtaaatgg tgtaaaagta ggttcagaac
    19921 ttattggtca aagctttaca gatgcgagat tctttaaggg aagagtatca tcagtaaact
    19981 ataatactta tacaaaagaa gatttagtac cagataaaga tggaaacaca tcttatggag
    20041 gtgtatcatc agggtctttt aattatggag ctacaaatcc agaacttcat gatagagtac
    20101 aaaaagatat agaacagttt ttaaaggata atccaactgt caaaagagag gatataccaa
    20161 cagatttact tacagcatca ggttcaggac ttgaccctaa tataagtcca gcctctgcaa
    20221 aaattcagat accagctata gcaaaagcgt ctggaatatc agaaagtaaa ttacaaaaaa
    20281 ttgtagaaga taatacttcc aaaaaacttt ttggagtttt aggtgaagat agagttaatg
    20341 tattaaaggt taatgtagag gtcgcaaaaa tattaggtct tatatagtat tttgtggaat
    20401 tttagcaaca aaatattact caagatttaa tttaaaggtt aaattttaaa gagtgaaaat
    20461 cgataatgat tttcactttt ttatttgaat attactaata tttggaataa agtgattgta
    20521 agtataaaat ccaaaaaaag gttgcattat caaaatgata atactataat atatttatcg
    20581 ttatcaattt gataatagat ttggacatat aggaggaaat agtatgttat ataataacgc
    20641 attagagttg ataggaaaca cacctgtagt aaggctgaat aatttaggct gtactaatgg
    20701 gtgttctaac atatatgtaa aattagaaaa agtaaatcca gcaggaagta taaaagatag
    20761 agctgtttat gaaatgttag agggtttaga gcaaagagga gaattaaaaa agggagatgt
    20821 actagttgaa gcaactagtg gaaatactgg tattgcatta tctatgatag gaaaattaaa
    20881 aggatatgaa gtagtaatcg taatgcccga aacaatgagc gttgagagaa gagatttaat
    20941 gaaggcttat ggagcaaatt tggtgcttac agatggtaaa gctggaatgg caggttccat
    21001 agaaaaagca aatgaacttt taaaagaaaa tccaaactat aaaagcttaa aacaatttga
    21061 aaataaagat aatccaaatg cacattataa aacaacagca gttgaaatta tgaatgatgt
    21121 caaagattta gatatattcg tatgtggagt tggaacaggt ggtactttaa taggaactgc
    21181 aagatattta aaagaacaaa atccaaatat aagagtaatt gcacttgaac caaaaaaatc
    21241 tccagctata tcagaaaaca agactggacc tcataaaata caaggaatag gtgctaactt
    21301 tgttcctgaa aattatgatt ctagtgtagt tgatgaagta atattagtag atgatgaaga
    21361 tgcatttgat acagttaaat tacttgcagc aaaagaggga attttagtag ggatatcttc
    21421 tggagcaaat atatttggtg ctatagagat ggcaaaaaag tatccagata aaaagatagt
    21481 tacagtagct ccagatggag ttgataagta tatgtctatg ggaatatttt aataatttta
    21541 tttgagggag tgaatacttt gtttaagaaa ataaataaag atattgaata tataatgaag
    21601 aatgatccag cagctaggtc taagatagaa gtttttttac tttatccatc agttcatgca
    21661 atgataatgc ataggatggc tcatgctctt tataagaaga agaagctttt tacagcaaga
    21721 ttaatatccc agatatccag atttatgact ggcatagaaa tacatcctgg tgctaaaatg
    21781 ggggaaggta tattgataga ccatggaatg ggtgttgtaa ttggagagac agctgaagta
    21841 ggtaataggg tgacaatata tcaaggagct actttaggag ctacaggaaa agatactgga
    21901 aagagacatc caactgttgg tgatgatgta ttaattggtg ctggaacaaa aatactagga
    21961 cctttaaata taggttcaaa ttcaaaaatt ggtgcaaatt ctgttgtcgt taaggatgta
    22021 cctaatggtg caacagttgt tggtatacca gcaaaaatag taaaaataag aaacctagaa
    22081 cctgtaaaaa agaataaaaa agaagtgtcc tatgagtatg atgaattaga taatgtatat
    22141 tatatatagg atttatataa ctataaaata aactttataa aaattatttt aaaaggtatt
    22201 tttttcaaat ttgaggacat aataaaaaag aactgaatgt tacagttttg gttcatcaat
    22261 ctttgataaa caagatttta aatttgtagc gtctaggagg attttattat gaaagcaaat
    22321 gttaatcaag atacttgtat aggttgtgga ttatgtccat caatatgtcc agaagtattt
    22381 gatatgaagg atgatgggaa atcacatgtt atagttgatg aagtaccaag tgatgctgaa
    22441 gaatcagcag cagaagctag agaaagctgt ccagttgatg caatagatgt gcattaataa
    22501 aataaatgcc tataaaaatt gaattttcaa tttttatagg catttgtctt ttattcagtt
    22561 agtatttcaa cacctgtttc tgtaactaaa accatacatt cccattgagc agataattta
    22621 ccatcttttg tataaatagt ccaattattt tcttcatcaa caaaaatttc gtgagttcct
    22681 tcatttacca taggttctat tgtgaatatc atcccaggaa ccaatagcat ctcagtccct
    22741 tttttagata cataacttac aaaagggtct tcatgaaagc ttaatccaac tccatgacca
    22801 cctatttctc taacaacaga gtatccattt ttctttgcat aagagttgat aacatcacct
    22861 atatctccta agaatcccca tggtttggca acttcaagac ctttttggac acattccttt
    22921 gtaacttgaa ctaatttttt tgcattttcg ttaacattac ctatcataaa cattcttgaa
    22981 gcatctgaat agtatccgtt aaaaatagta gaaacatcta catttataat atctccatct
    23041 tttaagataa tgtctttact tggaatacca tgacaaactt cattatttac tgatgtacat
    23101 acacttttag gaaatccatt atagtctagt ggagcaggga tagctccatt ttgtagtgta
    23161 aagtcatgaa ccaacttatt tatatcttct gtagacattc caatttcgat tttatctgaa
    23221 atataatcca aaatttttgt gtttattaca gcactttttt ttatttcctc aatttgactt
    23281 tcatttttta taatatcatg agttggtaca atatgaccta acttagcaaa tgaatctatt
    23341 ttattatcca tatccatatg acatttttta tattttttag tacttccaca ccaacagcta
    23401 tcatttctat ttaacttcat aacttttcat ccttctttta ttatttattt aaattatggg
    23461 ttacataaac tattttaaaa cataaccatt ataaatatta taacataaat actaagaaat
    23521 cctttataga tagtgattta ttcaaagtat aaattattat atggttattg ttgatgaaaa
    23581 gaggatagtt aaatgtatta ttggatatta gcgcacttaa tagtttagtt caagtttttc
    23641 aagaaaatca tatgttagag gacaattttc ctttaaagta ttttttgaat cttcatcaag
    23701 ataataatgt acaaatgatt ctgcaaaaaa ttcttctata aacttgctta tatatgcatg
    23761 tgcaacttgc ttagggtcat aaagcttata tctttcctga gcaaatactt ccataaattc
    23821 ttcagaattt gattttttat ttaaaacatt tttatctata gcatgtgcag tttcatgtaa
    23881 ttctaaattt tttgatgaat gtacatttgc atagctaggg ttactataac ctattttagc
    23941 cactatagaa ttatttctat atataccagg tacatctttc caagtcttgc ctgatcttac
    24001 ccaacatgga ggtaattgat attttaaatc actaaattct ggttcatcag ttagatttga
    24061 atttattaat tttattttta tatccttttc tttaagtgtc tgtaaatatt taatatttat
    24121 ttttgcaagt ctgtttttca tattttcaac ttcatcttta tcataattca agtcatcagg
    24181 aagtataagc atttgttcaa ttatatctat actactgtct tttatatttt cagattcttc
    24241 atcaaattta tattgaagag tattattttc atagatagtt atatttgtat tattttctat
    24301 agaataagag tgaatatcct ctaaatctaa aatattcatt tgttgtaaaa tatgttttgt
    24361 ttcgccactc cacactacta aagaaagtga attaaaatta attagtggat tttcttttgc
    24421 ttttatatca ttgcttatat ctacatcaaa tacatattca attgagtctt ctatgttaag
    24481 actatctgta ttctttttaa tatataaata cgcttgtttt aagtctatat aaatctcatc
    24541 taaagattcg tcataaaatt ctgataaatt attagtaaag agttcttcac ttaaaagttc
    24601 atttttatca gttatacttt caattaaaat attaatttct tttatcatat tgtaaatact
    24661 tatttttcta tttgcttttt cactagatac attgcatggc gcaagagcaa tgcaataaaa
    24721 atctttttct tttttataaa aggctttaag tgattttgat aaaagtgtaa agtctacacc
    24781 tatctgtaag ttgaccttaa gtgagtcatt ttgtaataat tcagtattat ttcttttagc
    24841 tgtatttaaa ttgttttcca taatcattgc ccccttttta ttagggtatc ataatttttt
    24901 tatatgtgtc aatttgtttt tttgaaaatt ataatttttt tgaaaatttt attttttata
    24961 atttgtgaat tttttattat agaaataaat atgttattat tatgtcaaaa ttt
//
LOCUS       DAEPID010000056        24886 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.056, whole genome shotgun sequence.
ACCESSION   DAEPID010000056 DAEPID010000000
VERSION     DAEPID010000056.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 24886)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 24886)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..24886
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.056"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            397..1674
                     /gene="hflX"
                     /locus_tag="KR257_002560"
     CDS             397..1674
                     /gene="hflX"
                     /locus_tag="KR257_002560"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003433865.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GTPase HflX"
                     /protein_id="HBH0031242.1"
                     /translation="MDMAKKGITVGLNINNKSEDFNELMIELENLCSACDIDVVGSIT
                     QNAKQVNRAFYIGTGKVEEILNLIKKENIEIVIFYNELSTSQLKNLEEKLNCEIIDRT
                     ALILDIFAQRAKTREAKLQVEVASLKYMLPRLIGSNENLGRQSGGVGTKNRGSGEKKL
                     ELDRRRIEEKITSLNRELDDLKFQRETQRSMRRKSNLPNVALVGYTNAGKSSIMNKLV
                     DIFKNSEEKKVFEKNMLFATLETSVRNIVLANNKEFLLSDTVGFVSNLPHDLVKAFRS
                     TLEEACEADVLLHVIDISNPSYKSHIKVTEDTLKQIGADGIPMIHVYNKIDLIDVDVL
                     DRILDSIDKEGIFVSVKKDINIDKMIKCICDSIFKDYVRCKFLIPYDKGHVVSYFNEN
                     MSIINTEYREDGAILDVECSNIEYNKYKKYALE"
     gene            1907..2404
                     /locus_tag="KR257_002561"
     CDS             1907..2404
                     /locus_tag="KR257_002561"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903083.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MarR family transcriptional regulator"
                     /protein_id="HBH0031243.1"
                     /translation="MDAETLMKKYMVDDDSRKQAIFASIFVMQNKLQTTCDKLDPELT
                     MKQWLLLAIADSVDETLTLTKLGELMGCSRQNVKKLAIALEKKGFIQIEQNEKDSRAI
                     CLVTKDRVQEYSKKVRGMQEKVLQLLFEDFTEKEVEQLFFGIMKLSIGIENVKNYVEN
                     NDVGE"
     gene            2454..2978
                     /locus_tag="KR257_002562"
     CDS             2454..2978
                     /locus_tag="KR257_002562"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897366.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flavodoxin"
                     /protein_id="HBH0031244.1"
                     /translation="MKNVVVIYKSKYGSTKKYAKWLSELLSCDIFETKNINIEKVMKY
                     DTIILGGGLYACNIAGISFLKKNYKELQKKNLVVFGVGAAPYDDEVIKKLREVNFKDE
                     LNKIPCFYCRGAWDETKMSFIDYTLCSFFKKSIAKKERQGLKPAEAPLLSGEAFDWCN
                     KENLTPILDYIREL"
     gene            3290..4654
                     /locus_tag="KR257_002563"
     CDS             3290..4654
                     /locus_tag="KR257_002563"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903082.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aldehyde dehydrogenase"
                     /protein_id="HBH0031245.1"
                     /translation="MDIKELVKMQRKYYNTGKTRDISFRIEQLKKLKLVVSQNEEKIL
                     LALKKDLNKSDFEGFMTEVGMFYSELNFAIKNIRKWSKIKRVKSSMVNFPSISKVVPQ
                     PYGVTLIMSPWNYPFQLALIPLVWSLVAGNCVILKPSEYSVSTSSVVKDIVEDTFSKE
                     YVAVVQGSQEESEKLLLERFDYIFFTGSTNVGKIIMKSASEHLTPITLELGGKSPCII
                     LKDANIDLTAKRLTWGKLINAGQTCVAPDYVLVHEDRKNELIEKIKYYTNKYFGDNPC
                     NNEQFPKIINQRHFNRILSLIDKDKIVYGGNYNKETLKIEPTIVDNVNWDDNIMKEEI
                     FGPIFPILTYKDLDEVIQKIIQMPNPLALYIFTKNKYLENKLLEMIPAGGCCINDTVT
                     HIATNYLPFGGIGESGMGSYHGKAGFDTFTHYKSVLKKLNLDVPIRYAPYDNKLIKVL
                     KKIM"
     gene            4793..5959
                     /locus_tag="KR257_002564"
     CDS             4793..5959
                     /locus_tag="KR257_002564"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430484.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AI-2E family transporter"
                     /protein_id="HBH0031246.1"
                     /translation="MKINWNTKYTTIAIYTFIIAASSIIFYLVSSQIDVFSNNLDAIF
                     TTLQPFIIGFAIAYLLNFILKFYEDRIFIKSEKLKKLKQSSKRGLGLLLTYATATLIL
                     YLFMHFVLPQVIESIVGLANDIPMYVNNATKLIDKLMTDLNLDEQYFNLAVDKWNEFV
                     TYIIKFVTDLIPILGSMLKNVASSIWNIVLGLIVSVYLLIDKEKFYGLSKKITYAVFT
                     EKQAARILELTHRSNYTFGRFLGGKILDSFIIGILTFVILTLVKMPYTLLISVIIGIT
                     NIIPFFGPLFGAIPSTLIVMFVSPIKAFWLLLIILIIQQIDGNIIGPKILGDSIGISA
                     FWILFSLLVAGKLLGFIGMVIGVPMFAVIYSIIKDIVESKLDKKGLPTDTSDYM"
     gene            6076..6858
                     /locus_tag="KR257_002565"
     CDS             6076..6858
                     /locus_tag="KR257_002565"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890379.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="esterase family protein"
                     /protein_id="HBH0031247.1"
                     /translation="MAFIECKFKSKYTGGETDIIVILPVANGKELFSGKEIYDFEGKF
                     KTLYLFHGLEDDQSSWIRYTNVEHYAKNKNIALVIPRVETSFYTDMAYGHQYFTFVSE
                     ELPKFVRAIFPLSDKREDNFVAGMSMGGYGALKLALSKPKEFSAVASFSGSPDMIHEL
                     ENQQIETNADILFHDFGRPEDARNSENDLLYILKNLKERNEDIPKIYQFCGDRDFLYK
                     NNQMFKKYADSLGVDVEYEECVGGHEWRLWNLWIKKFIDIIG"
     gene            complement(6977..7630)
                     /locus_tag="KR257_002566"
     CDS             complement(6977..7630)
                     /locus_tag="KR257_002566"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423398.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="HBH0031248.1"
                     /translation="MSKSEKGKETKASIISAARELFFEQGYHKTTTRQIAERANINLG
                     LISYYFSSKSEIGAIIYEDIRNEMQSLIYNYHEEGTMMMFFLAMNADLCFLLKNEAYR
                     NFYLDIAYEEAILSYQRSVTEMVMKRYVNDKESIEHDELILSCIGILAMKPEIIRVYT
                     SHKYDISSQAVIKHFTKQFLINLGHSTDLCEEILEELSKYYIDIVDNFTPIITRVRT"
     gene            complement(7654..9018)
                     /locus_tag="KR257_002567"
     CDS             complement(7654..9018)
                     /locus_tag="KR257_002567"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897363.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sodium:solute symporter family protein"
                     /protein_id="HBH0031249.1"
                     /translation="MLLLIVTCAIYIWIGFYFSKKVKTASDFLIAGRNLPLPILAATI
                     AATSFGGGCLVGGVQWGAERGLWVGMYSTIGAALACFINAFFAGKLRSLSCDITPADY
                     IETRYGHSVFLRAYQSLVTPISILAIMGSQLISFGSVSTAFGIPYDIAVIIGVIVIII
                     YTYTSGMWGVAVSAFIQLAICIVFLPIVAYISLKLVGDNPLLMLQSMVKEPFFPGNKS
                     ISDFMYTVLPLVLGSIFSYESFLRYQCADNAKNAVKSSVIAGFILLFLAFPIGIIGAI
                     GGSLFPNISSVQVLPQMISTTLPPLISVLFLAAILAAIMSTADSLMTSMSAIISRDIY
                     NKLLHPNIEFNDLKNTLKYSQIASALTAIIGAIIALKFDSLLELLFWPAPLCTGVIFA
                     PFVIGLCWKGATKKGAIYAVIVSVILALLNMIGILTVFDRILVPIIGGSITIFIVSKF
                     SKKD"
     gene            9677..11107
                     /locus_tag="KR257_002568"
     CDS             9677..11107
                     /locus_tag="KR257_002568"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009905807.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MFS transporter"
                     /protein_id="HBH0031250.1"
                     /translation="MSSQESKPKGNLISNFRDDMRDPKKRAIYTYSSSINLAYNFIGY
                     FVSTVTNIFLTDVAKLGVIMAGGMQIIQSFIKIAVAPITGTVFDKQPFKKGKYYPWLR
                     YAPAALALTYGIFFIVPLMKISPALLLPLMTALLLIASCAQQVVFTIIYAIYPVVAKT
                     PRDRVIGSTTTNIFKEVGKFLVGFSYPLLLVLFADVLGGEGMGYLGTYLFFAAGCLLV
                     FWFSSTEIIKSGAEEEVLQKEEKPKIKASEMAKALFTNVPLMMAFCLEFLICIRSIGL
                     GPLAPYYFKYVIEDERGLAVFLSIMPLVSVAFMFFAPVFIKICREQKLASIISFSICA
                     LCHLLVAWTPWGKTTLGVTMLLAIGGGFSNVVSIINLNFFAGSCDYGHWKSGKDLPGL
                     SMSLYPVAIQVGVLLATTIRTVLMNSMGYQADMVVTEAVKSGFINMISYSMAIPLIIA
                     VVIAILYPVSDKKLNQIREELNQRNA"
     gene            11210..12313
                     /locus_tag="KR257_002569"
     CDS             11210..12313
                     /locus_tag="KR257_002569"
                     /EC_number="2.6.1.9"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893521.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="histidinol-phosphate transaminase"
                     /protein_id="HBH0031251.1"
                     /translation="MIEKLLRNTVKELHQYVPGEPIEKVKEKYGVKEIIKLASNENPL
                     GPSPKAIEAMIEMLKQGQLYPEPEANELRRKLAEKLDLKPENFIVANGADNVITLIGE
                     AFINRGDEVIYCNPTFPSYRTATIKNEGIPVEVPLTEDYKYDLQGILDKITDKTKLIC
                     VCNPNNPTGTIVDDKELEEFLKKVPENIITILDEAYIEFLTVPNYVDGLKYVRENYNV
                     IVTRTFSKIYGLAGLRVGYGIAKDEIIRTLFTVKEPFSANRVAISGATAALDDEEFIK
                     ETYELNRVGMAYFKEEFTKMGFDVVDSQSNFLYVDMKTDIPKLFEDLKKRGFVIRPSA
                     THARVSIGTMEENKKFVAVLKEILNIKGEPSIG"
     gene            12328..12564
                     /locus_tag="KR257_002570"
     CDS             12328..12564
                     /locus_tag="KR257_002570"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012816256.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="4Fe-4S binding protein"
                     /protein_id="HBH0031252.1"
                     /translation="MKRGVDMNLKINAERCKSCEYCVISCKKGALKISSKINKEGYAH
                     VEVDESKCILCGICYQVCPDNVFEIIKEEACQEA"
     gene            12581..13630
                     /gene="vorB"
                     /locus_tag="KR257_002571"
     CDS             12581..13630
                     /gene="vorB"
                     /locus_tag="KR257_002571"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003433885.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="3-methyl-2-oxobutanoate dehydrogenase subunit
                     VorB"
                     /protein_id="HBH0031253.1"
                     /translation="MKKMWKGNHAIAEAALRGGCEFYAGYPITPQTEVIEFLSHRMSE
                     LGRTFIQSENEMAAIYMVYGAYASGMRSMTSSSGPGISLKQEGISYLCANHYPCVIVN
                     VQRWGPGLGSLDSAQTDYLRDTRGGGNGDYHLIVYAPNSIQETVDLMYNSFDVAEKYR
                     VPVEILTEAALGQMMEPVEFPEFKKREGDLGWTYDGSNRDHAKVADNQKPTFCMEKRM
                     RITENEQQWEDYQVEDAEYVFVAFGIPSRTTMNAVRRLREQGEKVGIIRPITVWPFPY
                     KAFEKVSKDVKGFISVESTDTGQLVEDVALTSKKVCKENVPVYGLFSGNHIPKTLQVM
                     DTYSKIKSGEIKEVF"
     gene            13632..14372
                     /locus_tag="KR257_002572"
     CDS             13632..14372
                     /locus_tag="KR257_002572"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003433887.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="2-oxoglutarate oxidoreductase"
                     /protein_id="HBH0031254.1"
                     /translation="MATEKLTPSVVSIPNKFCPGCGHGIVNRIIAEVIEEHGYEKNHV
                     LTLGVGCVCNMNFSWNGDKMQTAHGRASSTAIGVKVALPDTLVMTYQGDGDAYVIGLS
                     ETLNTAYRNHNVTVFVINNNNFAMTGGQMSWTTMPGQVTTTSVNGRDIKTTGSPLKVP
                     EMVANFFDVAYVARGSVHSPKEIINLKKYIKNAIEAQLNGEGYSLVEILAPCPTNWGV
                     SLEKSIKWMEEEIVPYYALGEFKQRDGE"
     gene            14375..14914
                     /locus_tag="KR257_002573"
     CDS             14375..14914
                     /locus_tag="KR257_002573"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003433888.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="2-oxoacid:acceptor oxidoreductase family
                     protein"
                     /protein_id="HBH0031255.1"
                     /translation="MEKELVFAGFGGQGVLTLGLIVAESALELGKQVTWMPAYGPTMR
                     GGKAYSVVKFSDESIGGPDMEEIDVLVAMNKPSLDYINLVKEGGTVVINTSAIDENVT
                     LREDISVVKINCQELAQKVNNPKAANIVVLGALIAKTGLFEKELALKTMCDFFEEKGK
                     GKFNVQNEAAFMEGYNNAI"
     gene            15038..17137
                     /locus_tag="KR257_002574"
     CDS             15038..17137
                     /locus_tag="KR257_002574"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423413.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="acetate--CoA ligase family protein"
                     /protein_id="HBH0031256.1"
                     /translation="MSLEKLIRPKSIAIVGVTDKLGFGRSAALSIVKSKETDRVYYVN
                     PKREELFGRKCYKTIQEVPEVVDCVVVCTPRNVVPSVLKDSGELGTKAAVVYASGFAE
                     EGTEEGTDLENQLIEISNTYDMKILGPNCMGLLNCIDKVNLWAGGSKWDLDTKKPGIG
                     IVGQSGFITAEIVSSDYFNISYGFSTGNGNIVTLEDAVDFLVDDDYASVIAIYLEGLK
                     NPQKFIDALKRAAQKRKPVIILKSGRSEKGAISAASHTGNLAGSSKAFESIFEKYGVI
                     SVENLEQFMCLAQAFSVLDGNLPANSNFAAINFSGGENTICADLAEENGVELAEISSE
                     TKEEMKKYLPGFATPKNPLDATTALFHEKDMIVGLLHTFEKDDSVGFTMVGANIRDEE
                     NEMHETLCKAVSEAREQGLKKPVFAVPTLEGNRYLDYRTRLEDNQVPIMSSVGTTFTC
                     FNKMAKFIDYDYSKRTLEFKAVKKRESNNVVALSELDSKIEMKKYGVPVPGQGNAKSI
                     DELDEILKYIKYPVVLKINSSEILHKSDVGGVKIGIENRDEAVDAYNEILTNVKKAKP
                     DANIDGILVQEMVESGIEIIIGITNDDQFGPMLLVGLGGVFVEVFKDTTLYPLPINHD
                     EAIMMLKKLKSFKLLNGYRGSEPCDIDALADMMVKLGKYAYENKDEVKEIDLNPVFVY
                     PKGKGVCAVDALIVKYK"
     gene            complement(17404..17919)
                     /locus_tag="KR257_002575"
     CDS             complement(17404..17919)
                     /locus_tag="KR257_002575"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423414.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ferritin"
                     /protein_id="HBH0031257.1"
                     /translation="MISAKMEKLLNEQINHELYSAYLYLSMSSYLEAEGLKGFSNWFY
                     VQYKEETDHAMFFYKYLHNVGGKVQLDAIPMPDSDFTSAMDILERTLAHEKKVTALIN
                     NLAAVANSESDFRTSQFLLWFISEQAEEETNCEDNIKRVKLAGEGGLFFVDQEFANRT
                     YAAPTNPPVTI"
     gene            complement(18011..19222)
                     /locus_tag="KR257_002576"
     CDS             complement(18011..19222)
                     /locus_tag="KR257_002576"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890368.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ROK family transcriptional regulator"
                     /protein_id="HBH0031258.1"
                     /translation="MSNKQGSNIKDVKIKNKLIILKLLSTNTPMSRVDLAKSTGLTKM
                     TLSNLVTELINENMIREIESSTLNAHSSGRKPILLDISNISPCICGILIRRNICKVII
                     SDLKGNIVKQLSETYPKCLSNDVLKDIIKRMFTKIMKINKRDIIGIGISSIGPVDDIN
                     GTILNPPDFGNVSNLNIVDFIKEMSDLPIFLINDANSGALAEKMYGLGKNISNYIYLH
                     IMNGIGAGLVLENKLHTGNLGQSGEIGHTSINFSGPLCSCGNNGCLDYYTSVSNLIKR
                     IESLSHIYPNSPLINCKDFSLVKLIDEANNKDSLAMFLLDEFCTYVSYALVNTLTLID
                     CSSIIIGYDFNIPGTFIENTLLKKLTASASFSKYKKISVRHSNFGANAPLIGSIAIVS
                     YNFFNGSINFY"
     gene            19898..21340
                     /locus_tag="KR257_002577"
     CDS             19898..21340
                     /locus_tag="KR257_002577"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423418.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell wall-binding repeat-containing protein"
                     /protein_id="HBH0031259.1"
                     /translation="MRTIRRVLALGLTLAIFLINVPNVDALTSDTIKGNNIYETAGLI
                     ADKKSYDTAIMVNMDNSIADGLSASGLAGAVDAPILLAQKNKIPNETKQRLKNVKKIY
                     IIGKELSISKSVETELKNTGAQVTRLGGDDRIKTSYSVAKEVNGIKKVDEVILTNAYK
                     GEADTISAAPVSVRDIAPIVLTDGKSVPFSTSNVKTYAVGGSISMSTSLVNKTNAKRL
                     GGSDRYDTNKKVIKEFYPDASEFYLSDGYDLVNALTGSTIAKENPIVLVSESSDKSIL
                     AGADKITRLGSISDSVYNKCVSAAQNNGDSSTKGESPMKNETSILGQPTASLEACLKW
                     AKSKKANDLFIELIPILYDTAVQEGVNPVLAVAQSAKETGFCNFGGVLDASFKNPCGL
                     KTSVGGSDTDKNAHSRFDTWEEGILAQIQHLCLYAGQDGYPLSNPVDPRHEKSLFGKA
                     KTVESLSNNWAGGQYGQDLVRMMGEIEATK"
     gene            21382..21735
                     /locus_tag="KR257_002578"
     CDS             21382..21735
                     /locus_tag="KR257_002578"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423420.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0031260.1"
                     /translation="MKKSNIFSIIFPTVIMVLMFLTFATDIFNIPDIQSKSIFVVGMV
                     LIFPISFLIQGIICVLNKTNWILSLIVSLVTYIVLMYIFLNDSAYIYVLLYTAFYMIG
                     HITAKLYYKIKTFKN"
     gene            21926..22747
                     /locus_tag="KR257_002579"
     CDS             21926..22747
                     /locus_tag="KR257_002579"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003433897.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="histidinol-phosphatase HisJ family protein"
                     /protein_id="HBH0031261.1"
                     /translation="MNLIDNHIHTNFSSDGKDSMEDTIKKAISIGVRYLTFTDHLEHD
                     EDRGFCINYNDYVPVFNKFKEKYKKDIELLLGVEVGYRKHLKNEIEEIINSNPFDFVL
                     CSTHTIDNVPVPSKEYFKGLSKEDAYYKYFNSILETNREFGDYNIYGHLDYISRYGIY
                     SDNRVIYNDFKDVIDEVLKSIINNGSGIELNTSGYRYGLNAIHPNEDILKRYKELGGF
                     IVTVGSDSHRVEDICKDFDVAYDMLKYLDFKYVSLFKERETYFVNIEKVKSNNIA"
     gene            23005..>24886
                     /locus_tag="KR257_002580"
     CDS             23005..>24886
                     /locus_tag="KR257_002580"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430505.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha-glycosidase"
                     /protein_id="HBH0031262.1"
                     /translation="MSNKNKENITLSNQIKGTIQNSLTKEAILHIPMSNYAYGYDRET
                     LHIRLRTKKNEAKRVILRIGDQYVWDKGGAGGGNLNASGVGWSGGTNIVMSKEVETEL
                     FDYWIAKCKPLNKRSRYGFIIEGQEEKLLFTEKRIIELGNENDEKELCEIGNFFGYPY
                     LNYIDIPKVPNWVKDTVWYQIFPDRFANGDPSINPEGVDKWGAIPTRDNFTGGDLQGV
                     IEHLDYLSDLGINGIYFCPITIGKTNHRYDTVDYMEVDPTLGDKETLKKLIEEAHKRN
                     IKIMLDAVFNHIGYYSKQWQDVVQNKENSRYKNWFYIKDMSKIDTPIEQIDEKNIPYE
                     TFGCEKYMPKLNTENSEVIKYLLDVGKYWIQEFDIDAWRLDVSNEVDHVFWRKFREEV
                     KKVKPDIYILGEIWHGSLPWLMGDQFDSVMNYLMSEAMKKFFCTDEINAEEFKYMIND
                     VMVSYPIQVSEVIFNLLGSHDTTRILTYANGNIDRFKLAYMFMFVQTGCPCIYYGDEI
                     GMEGELSSISEGQRKCMEWNEEKWNKDIFDFMKKIIRLRKENKELRSISNEWVLADKE
                     NGTIILKKESISIIINNSSKNIILTLPDYLANKKVKDLYEEEIVDLKEELMLEKYKFI
                     ILK"
BASE COUNT         9644 a         2792 c         4286 g         8164 t
ORIGIN      
        1 tttttattac ttttattaat catgcaaata actacttaaa tttaagaata gggttaaata
       61 taaaatgata attacatata agttaattaa actaatgtat ttttaatata tatttagaat
      121 tttaatcctt cttatgatat aagtagcttg ttttgtatta cttagatttg taaggagttt
      181 ttttattgaa aaaactgcat aatatatttg ggaggaggtg taagaaagtg attttttata
      241 taagattgag aaaataatgc acgattatgg ttattataat agtaaataag aagtgtcatt
      301 taaggataag ataaaaagca aaattcttga tgaatttaat tatagagcca taatctcgtg
      361 ctatagatta aataaaaaat agcagataag gagaatatgg atatggcgaa aaaaggaata
      421 acagtaggat taaacataaa taataaatct gaggacttta atgaactaat gattgaactt
      481 gaaaacttat gttcagcatg tgatattgat gttgtaggga gtataactca aaatgcaaag
      541 caggttaata gagcatttta cattgggaca ggtaaagttg aggaaatatt aaacttaata
      601 aagaaagaaa atatagagat agttatattt tacaatgaac tttctacatc acaactaaaa
      661 aatcttgaag aaaagcttaa ttgtgaaatt atagatagaa cggcattgat acttgatata
      721 tttgcacaaa gggcaaaaac tagagaagct aaacttcaag tagaagtagc aagtttaaaa
      781 tatatgttac caagacttat aggttcaaat gaaaatttag gacgtcaaag tggtggagtt
      841 ggtactaaaa atagaggttc tggtgagaaa aaattagaac ttgaccgtag aagaatagaa
      901 gaaaagataa catctttaaa tagggagttg gatgatttaa aattccaaag agaaactcaa
      961 agaagtatga gaagaaaatc aaatcttcca aatgtagctc tagtcgggta tacaaatgct
     1021 ggtaaatctt caataatgaa taaactagta gatatattta aaaactctga agaaaagaaa
     1081 gtgtttgaga aaaacatgtt atttgctaca cttgaaactt ctgtcagaaa tatagttctt
     1141 gcaaataaca aagaattttt attatctgat actgttggtt ttgtaagtaa tctaccacat
     1201 gacttagtaa aagcatttag gtcaacatta gaagaagcat gtgaggcaga cgtactgtta
     1261 catgttattg atatttcaaa tccaagctat aaaagtcata ttaaagtgac agaagatact
     1321 ttaaaacaaa taggtgcaga tggtatacct atgatacatg tgtataataa aattgattta
     1381 atagatgtag acgtattgga tagaatttta gatagtattg ataaagaagg tatatttgtt
     1441 tcagttaaaa aagatataaa tatagataaa atgataaaat gtatttgtga tagcatattt
     1501 aaagattatg taagatgtaa gttcttaatt ccatatgata aaggtcatgt agtttcttat
     1561 tttaacgaaa atatgagcat tataaataca gaatacagag aagatggagc tattttagat
     1621 gtagaatgta gcaatataga atataataag tataaaaagt atgctttaga gtaaattttg
     1681 aaaaacttat tatagcctaa aatatattta atttataatt tattataaat tgattgtaaa
     1741 tatgatttta tgaaacggta tagccataat gctatgccgt tttgccattt ataataaaaa
     1801 taaatttatt gacataatag taactaatta ctataatata aagtaattag ttactattta
     1861 aaattatcaa aaaattaaaa tctaagataa agagaagtgt ataataatgg atgcagaaac
     1921 tttaatgaaa aaatatatgg tagatgatga tagtagaaaa caagctatat ttgcaagtat
     1981 atttgtaatg caaaataaac ttcaaactac atgtgataaa ttagacccag aattaacaat
     2041 gaaacaatgg ttacttttag ctattgcgga ctctgtagat gaaactctta cattaaccaa
     2101 acttggagaa ttaatggggt gctcaagaca aaatgtaaaa aaactagcta ttgctttaga
     2161 aaagaaaggt tttatacaaa ttgagcagaa tgaaaaagat tcaagagcta tctgtcttgt
     2221 gacaaaagat agagtgcaag agtattctaa aaaagtaaga ggtatgcagg aaaaagtatt
     2281 acagctttta tttgaagatt ttacagagaa agaagtggaa cagttatttt ttggaattat
     2341 gaaattaagt ataggaattg aaaatgtgaa aaattatgta gaaaataatg acgttggaga
     2401 ataagcaagt atcaaatcaa ctttgtatga catcagagag ggggataatt tatatgaaaa
     2461 atgtagtagt gatttataag agtaagtatg gttcaacaaa aaaatatgct aaatggcttt
     2521 cagaattatt gtcttgtgat atttttgaaa ctaagaatat taatatagaa aaggttatga
     2581 agtatgatac gattatttta ggaggaggtc tttatgcttg taatatagcg ggaatttctt
     2641 tcttaaaaaa aaattataaa gaattgcaga aaaaaaattt agtagtattt ggcgtaggag
     2701 ctgctccata tgatgatgaa gtaataaaga aattaagaga agtaaatttt aaggatgaat
     2761 taaacaaaat tccttgcttt tattgtcgtg gggcatggga tgagacaaaa atgtctttta
     2821 tagattatac tctttgtagt ttttttaaaa aatctatagc taaaaaagaa cgtcaaggtc
     2881 ttaaaccagc agaagcacct ttattgtctg gagaagcatt tgattggtgt aataaagaaa
     2941 atttaactcc aatacttgat tatataagag aactttaaga ggtatatatt tataattatt
     3001 tattatctaa agttagattt catagaaact tactagacat tatttataaa ataatattat
     3061 taaagatgga taatttaatt gattcaataa ggttataatt ttaaaaaatg tttattttaa
     3121 aataaattat tttataagct tacttatact taataagggg ctttttttat tggaagattt
     3181 atgttatatt gagatgaatt tattatgata taaaaaataa tgttaggata aatttaaatc
     3241 tttttctaaa aatgtattaa tataattctt aaagaaagga tttttaataa tggatataaa
     3301 agagttagtt aaaatgcaaa gaaaatatta taatacaggt aaaacaagag atatatcgtt
     3361 tcgtatagaa cagttgaaga aacttaagtt agttgtatca caaaatgaag aaaaaatact
     3421 tttagcacta aagaaagatt taaataaatc ggattttgaa ggttttatga cagaagtagg
     3481 catgttttat agtgaattaa actttgctat aaagaatata agaaaatgga gcaaaataaa
     3541 aagagttaaa tcaagtatgg ttaattttcc atctatatcc aaagttgttc cacaacctta
     3601 tggtgttact ctcataatgt caccttggaa ttatccattt caattagcac ttataccatt
     3661 agtttggtca ttagtagcag ggaattgtgt tatattaaaa ccttctgaat attctgtgtc
     3721 aacatctagt gtagttaaag acatagtgga agatactttt tcaaaagaat atgttgcagt
     3781 tgttcaagga agtcaagaag aaagtgaaaa gttactattg gaaagatttg attatatatt
     3841 ttttacagga agtactaatg ttggtaaaat aatcatgaaa tcagcatcag agcatttaac
     3901 tcctattact ttagaacttg gaggaaaaag tccttgtatc attttaaaag atgctaatat
     3961 agaccttact gccaaaagac ttacttgggg aaaactaata aatgcaggac aaacctgcgt
     4021 ggctccagat tatgttttag tgcatgaaga tagaaaaaat gagttaatag agaaaataaa
     4081 atattatact aataagtatt ttggagataa tccatgtaat aatgagcaat ttcctaaaat
     4141 cataaatcag agacatttta atcggatatt atctcttatt gataaagata agatagtcta
     4201 tggtggaaat tataataagg agacattaaa gatagagcca actatagtag acaatgttaa
     4261 ttgggatgat aatataatga aggaagaaat atttgggcct atatttccca ttttaacata
     4321 taaagattta gatgaagtaa tacaaaaaat tatacaaatg ccaaatccat tggcacttta
     4381 tatttttaca aaaaataagt acctagaaaa taaactttta gaaatgattc cagcaggcgg
     4441 atgttgtatc aatgatacag ttactcatat agctacgaat tacttacctt ttggtggtat
     4501 tggtgaaagt ggtatgggct catatcatgg aaaagctgga ttcgatacat ttactcacta
     4561 taagagtgtg ttaaaaaaat taaatttgga tgtccctatt agatatgctc catacgataa
     4621 taaattaatt aaggttctta aaaagataat gtaggttata ttgtagaata ataaatataa
     4681 ataaaattga gtatttgtat tctgaatata ttttattttt aatttggtat atttgttata
     4741 aaagtggtga ttttgtgata aaatttaatt atatagaaat aaggaggaaa aaatgaaaat
     4801 taattggaat acaaaataca caacaatagc aatttataca tttataatag ctgctagtag
     4861 tattatattt tatctagtat catcacaaat tgatgtattt tctaataatt tagatgctat
     4921 atttacaaca ttacaacctt ttataatagg atttgctatt gcatatcttc ttaattttat
     4981 tttaaagttt tatgaagaca gaatttttat aaaaagtgag aaattaaaaa aactaaaaca
     5041 aagttcaaaa agaggcttgg gtcttttatt aacatatgca acagctacat tgatacttta
     5101 cttatttatg catttcgtat tgccacaagt aattgagagt attgttggac tagcaaatga
     5161 tatacctatg tatgtaaaca atgcaactaa gcttattgat aaattaatga ctgatttaaa
     5221 tcttgatgag caatacttta atttggcagt tgataagtgg aatgagtttg ttacatatat
     5281 tataaagttt gtaacagatt taatcccaat attaggaagt atgttaaaga atgtagcctc
     5341 tagtatatgg aatattgtac taggattaat tgtttcagta tacttattaa ttgataaaga
     5401 aaaattctat ggattaagca aaaaaataac ttatgcagta tttacagaaa aacaagctgc
     5461 cagaatttta gaattaactc atagaagtaa ctatacattt ggaagatttt taggtggcaa
     5521 aatattagat tcattcatta taggtattct aacatttgta atacttacgt tagttaaaat
     5581 gccatataca ttattaatat cagttataat tggtattaca aatattatcc ctttctttgg
     5641 acctttattt ggagctatac catctacgct aatagtgatg tttgtatctc ctataaaagc
     5701 tttctggtta ttgttgatta tattaataat acaacagata gatggaaata ttataggacc
     5761 taaaatactt ggagattcaa ttggtatatc tgcattttgg attttgttct ccttattggt
     5821 tgcaggaaaa ttattaggtt ttattggaat ggttatagga gttccaatgt ttgcagtaat
     5881 ttattctata attaaggata ttgttgaaag taaattggat aaaaagggat taccgacaga
     5941 tacttccgat tatatgtagc taaaaaatat tatgtataat taaaaatata taaattaagc
     6001 aatatttaaa gcactgagaa agttaaactc ttggtgcttt ttagatataa aattattata
     6061 gaagaggtgt tttttgtggc atttatagaa tgtaaattta aatctaaata tactggagga
     6121 gaaactgata taattgtaat tttgcctgta gcaaatggaa aagaactttt tagtggtaaa
     6181 gagatatatg attttgaagg taaatttaaa acattatact tatttcatgg tttagaagat
     6241 gaccaaagct catggattag atatactaat gtagagcatt atgctaaaaa taaaaatata
     6301 gccctagtaa taccaagagt agaaactagt ttttataccg atatggcgta tggacaccaa
     6361 tattttactt ttgtaagcga ggaattacct aaatttgtta gagctatatt tcctttatca
     6421 gataaaaggg aagataactt tgtagctggt atgtctatgg ggggatatgg agctttaaaa
     6481 ttagcgcttt caaaaccaaa agagttttcg gcagttgcaa gtttttctgg ttcgcctgat
     6541 atgattcatg agttagaaaa tcaacaaata gaaaccaatg cagacattct atttcacgat
     6601 tttggtagac cagaagacgc tagaaatagt gagaatgatt tactttacat acttaagaac
     6661 cttaaagaaa gaaatgaaga tattcctaaa atttatcaat tttgtggtga tagagatttt
     6721 ttatataaaa ataatcagat gtttaaaaaa tatgcagatt ctctgggtgt agatgttgaa
     6781 tatgaagagt gtgtaggggg gcatgaatgg cgtctttgga atttatggat aaagaaattt
     6841 atagatataa ttggatagta cacttatggt attaacaggt atactataaa atatctttaa
     6901 atatgataaa gactgaaatc ctaaaatcaa attatgattt taaaatttca gtctctaaga
     6961 atttaataaa attttattaa gttcttacac gagttattat tggagtaaaa ttgtcaacta
     7021 tatctatata gtatttactc aattcctcta aaatctcttc gcataaatcc gtactatgac
     7081 caagattaat aagaaactgt tttgtaaaat gctttattac agcttgagaa gatatatcgt
     7141 acttgtgtga agtataaact ctaattattt caggtttcat agcaagtata ccaatacaag
     7201 aaagtattaa ttcatcatgt tctatagatt ctttatcatt aacatatctt ttcatgacca
     7261 tttcggttac acttctttga tagcttaaaa tagcttcttc ataagctata tccaaataaa
     7321 aatttctata tgcttcgttt tttagaagga aacaaaggtc agcattcata gcaagaaaga
     7381 acatcatcat agtaccttct tcatggtagt tatagattaa agactgcatt tcatttctta
     7441 tatcttcata tattatagct cctatttcgc ttttacttga gaagtaatag cttattagac
     7501 ctaaatttat attagctctt tctgcaattt gcctagttgt tgtcttatga taaccttgct
     7561 caaaaaataa ttctctagca gcacttataa tactagcttt tgtttctttg cccttttctg
     7621 attttgacat atttactgtg tatacctctc ttttcaatct ttttttgaaa atttgctaac
     7681 tataaatatt gtaatagaac cacctattat aggaaccaaa attctgtcaa atacagtaag
     7741 aataccaatc atatttaata atgccaatat aacacttact ataacagcat agatagctcc
     7801 tttttttgta gcacctttcc agcaaagacc aattacaaat ggtgcaaata ttacacctgt
     7861 acataatgga gctggccaaa acaataattc taataaacta tcaaatttaa gtgctatgat
     7921 tgcacctatt atagctgtca aagctgatgc aatttgagaa tactttagag tattttttaa
     7981 atcattaaat tctatattag gatgtaataa tttgttataa atatctcttg atataatagc
     8041 actcattgag gtcattaatg aatcggcagt agacattatg gcagccaata tagcagctaa
     8101 gaataataca gatattaaag gtggcaaagt agtcgatatc atttgaggta aaacctgaac
     8161 agatgatata tttggaaata aactaccacc aatagctcca attattccta tagggaaagc
     8221 aagaaataat agtataaatc ctgcaattac actactttta actgcatttt tagcattatc
     8281 agcacattga tatcttaaaa aactttcata agaaaatatt gagcctaaaa ctaatggtaa
     8341 aactgtatac ataaaatcac taatcgattt atttcctgga aagaatggtt cttttaccat
     8401 tgattgtaac ataagtaaag ggttgtcgcc aactaatttt aagcttatat aagctactat
     8461 tggcaaaaac actatacaaa tagcaagttg aataaatgct gatactgcaa ctccccacat
     8521 tcctgatgta taagtatata taatgataac tataactcct ataattacag ctatatcata
     8581 aggaatacca aatgcagtag atacagaacc aaaagaaatc aattgactac ccataatagc
     8641 tagtatagat attggtgtta caagactttg ataagctctt aaaaatacac tatgaccata
     8701 tctagtttca atataatcag caggtgttat atcacaagat aagcttctta attttcctgc
     8761 gaaaaatgca tttataaagc aagctaaagc tgcacctata gtagaataca ttccaaccca
     8821 aagtcctctt tcagctcccc attgaactcc accaactaag caccctcctc caaaagatgt
     8881 agcagcaatg gttgcagcta gtataggcaa aggcagattt ctacctgcga ttaggaaatc
     8941 ggatgctgtt ttaacttttt ttgaaaaata aaaaccaatc catatgtata ttgcacacgt
     9001 aacaattaaa agtaacatag tcttttctcc tttataaaat attttaataa aatatacaaa
     9061 atatatttaa aatatatttt atataaaagt agtacgatat ttgttttatt ggttttagat
     9121 taatatagct ataataattt atgatattag atggaaatta cgtaaaaata gaaaattgaa
     9181 aattctgaaa tttttgtata ttgatattta tctcatagat tcttttttgt aattgtaaca
     9241 cgcttttatt tttaaatcaa tagtacatgt ataaaaataa aaggaattta aataagaaaa
     9301 agatattttt aatatctgga tgtagtatag aaatatcttg aataaattat tcttgaataa
     9361 aattataaaa aattaaaatc actagaaata tgataaaata atttaaaata cgcatttcaa
     9421 tgacatttca aaacaataaa ataataaaaa acaaacctaa attaagtcta aatagctttt
     9481 tagttaattt tagtagtaaa aaataaaact taaaaagtgt ttgacaatta tgaattttga
     9541 gaatataatt aaattaaaat tatacacata taaaaatata ctcctgaatc aagaatgaga
     9601 tatttaagat tcaaaatata tattattata cgtgaataat aaaaaagtaa gaaaatttta
     9661 taagggaggg gtagatgtga gtagtcaaga aagcaaacca aaaggaaatc ttatatcaaa
     9721 ttttagagat gatatgagag accctaagaa aagagcaata tacacatatt caagttctat
     9781 aaacttagcg tacaatttta taggttactt tgtatcaact gttacaaata tttttttaac
     9841 tgatgtggca aaacttggtg taattatggc aggtggtatg caaattatac aatctttcat
     9901 aaaaattgct gtagctccta taacaggtac agtatttgac aaacaaccat tcaaaaaagg
     9961 aaagtattat ccatggctta gatatgcacc agcagcgtta gcattaacat atggaatatt
    10021 tttcatagtt ccattaatga aaataagtcc agcattactt ttacctttga tgacagcttt
    10081 attattaata gcatcttgtg ctcagcaagt agttttcact ataatttatg ctatttaccc
    10141 tgtagttgct aagacaccta gagaccgagt tataggctca actactacga atatatttaa
    10201 agaagttggt aaattcttag taggtttttc atatccgtta ttattagttt tatttgcaga
    10261 tgtattaggt ggagaaggaa tgggttattt aggtacctac ttattctttg cagcaggatg
    10321 ccttttagta ttttggtttt cttcaacaga gataataaaa tctggagcag aagaagaagt
    10381 tcttcaaaaa gaagagaagc caaagattaa agcaagtgaa atggcaaaag ctttattcac
    10441 taatgtacca cttatgatgg cattttgttt agaatttctt atatgtataa gatctatagg
    10501 attaggacct ttggctccat attattttaa atatgtaata gaagatgaac gtggattagc
    10561 agtattttta tcaatcatgc ctttggtaag tgtagcattc atgtttttcg caccagtgtt
    10621 tataaaaatc tgtagagagc aaaaactagc ttcaataatt tctttttcta tatgtgcact
    10681 atgccactta ttggttgcat ggactccttg ggggaaaact actttaggag taactatgtt
    10741 gctggcaatt ggtggaggtt tttcaaatgt agtatcaata ataaatctta atttctttgc
    10801 cggttcttgt gattatgggc attggaaatc aggaaaagac ttacctggct taagtatgtc
    10861 actatatcca gttgcaatac aagtaggagt attacttgca actactataa gaacagtttt
    10921 aatgaactca atgggatatc aagctgatat ggtagtcaca gaagcagtta aatcaggttt
    10981 tataaatatg atttcttatt ctatggcaat acctttaata atagctgttg ttatagcaat
    11041 actatatcca gtaagtgaca agaaattaaa ccaaataaga gaagagttaa atcaaagaaa
    11101 tgcttagtta aaagaaagtt aagtagatgg ttaatttaag ctattaaagt aagtagacgc
    11161 aatagcgttt atataaatga aaatacatat acagaggggg cttttaaaaa tgatagaaaa
    11221 attattgaga aataccgtaa aagaattaca tcaatatgtt ccaggtgaac caatagaaaa
    11281 agttaaggaa aaatatggtg taaaagaaat aataaaatta gcttcaaatg aaaatcctct
    11341 aggaccatca ccaaaagcaa tagaagctat gattgaaatg ttaaaacaag gtcaacttta
    11401 tccagagcca gaagctaacg aacttagaag aaaattagct gaaaagctag atttaaaacc
    11461 agaaaatttt attgttgcta atggtgcaga taacgttatc actctaatag gtgaggcttt
    11521 tataaataga ggagatgaag ttatatattg taacccaaca tttccatcat atagaactgc
    11581 aactataaaa aatgaaggga taccagtaga agtaccttta acagaagatt ataagtatga
    11641 tttacaaggt atattagata agattacaga taaaacaaaa ttaatatgtg tatgtaaccc
    11701 taataatcca acaggaacaa ttgtggatga taaagagtta gaagaatttt taaagaaagt
    11761 ccctgaaaat attataacta tattggatga agcatatata gaatttttaa cagttcctaa
    11821 ttatgtggat ggacttaagt atgtaaggga aaattataac gttatagtaa caagaacttt
    11881 ctctaaaata tatggtcttg cagggcttag agtaggatat ggtattgcta aagatgagat
    11941 aataagaact ttatttacag taaaagagcc tttctctgca aatcgtgttg ctataagtgg
    12001 agcaacagca gcacttgatg atgaagagtt tataaaagaa acatatgaat taaatagagt
    12061 tggaatggct tactttaaag aagagtttac aaaaatggga tttgatgttg tagattcaca
    12121 atcaaatttc ctttatgtag atatgaaaac agatatacct aagttatttg aagacttgaa
    12181 aaaaagaggg tttgtaataa gaccaagtgc tacacatgca cgtgtaagta ttggaactat
    12241 ggaagaaaat aagaaatttg tagcagtttt aaaggaaata ttaaatatta aaggagagcc
    12301 aagtattgga taatagatag aaatattatg aaacggggtg tagatatgaa cttaaaaata
    12361 aacgcagaga gatgtaaaag ttgtgaatac tgcgttatat cttgtaaaaa aggagcatta
    12421 aaaatatcaa gtaagataaa caaagaaggt tatgctcatg tagaagttga tgagagtaaa
    12481 tgcatacttt gtggaatttg ctatcaggtg tgtccagata atgtttttga aataattaaa
    12541 gaagaagcat gtcaagaggc ttagaaggag ttgggataat atgaaaaaga tgtggaaggg
    12601 gaaccacgcc attgcagaag cagccctaag aggaggttgt gaattttatg caggatatcc
    12661 aattacacca caaacagagg taattgaatt tttatcacat agaatgtctg aacttggaag
    12721 aacttttata cagtccgaaa atgagatggc tgctatatat atggtatatg gagcatatgc
    12781 aagtggaatg aggtctatga cgagttcttc aggaccagga atatctttaa aacaagaagg
    12841 gatttcttac ttatgtgcaa atcattaccc ttgtgtaatc gtaaatgtac agagatgggg
    12901 gcctggtctt ggctcattgg actcagcaca gacagactat ctaagagata ctagaggggg
    12961 aggaaatgga gattatcatt tgatagttta tgcaccaaac agtattcaag agactgtaga
    13021 tttgatgtat aactcatttg atgtagcgga gaagtacaga gtgcctgtcg aaattttgac
    13081 agaagcagct ttaggtcaaa tgatggaacc agtagaattt ccagagttta agaagagaga
    13141 aggagattta ggctggactt atgatggaag taatagagac catgcaaagg ttgcagataa
    13201 ccaaaagcca actttttgta tggagaaacg tatgagaata actgaaaatg aacaacaatg
    13261 ggaagattat caagtagaag atgcagaata tgtgtttgta gcgttcggta taccatcaag
    13321 aacaactatg aatgctgtta gaagacttag agaacaaggt gaaaaagttg gaataataag
    13381 accaataaca gtatggcctt tcccatataa agcatttgaa aaggtaagta aagatgtaaa
    13441 aggatttatc tcagtagaat caacagacac aggtcaatta gtagaagatg ttgctttaac
    13501 ctcaaagaaa gtatgtaaag aaaatgtacc tgtgtatggt ttatttagtg gaaatcatat
    13561 accaaaaaca ttgcaagtaa tggacactta tagcaaaata aaatctggcg aaatcaagga
    13621 ggtgttctaa tatggctaca gaaaaattaa cacctagcgt tgtttcaata ccaaacaagt
    13681 tttgcccagg ttgtggtcat ggaatagtaa atcgtataat agcagaggta atagaagaac
    13741 atggatatga aaaaaatcat gtattaacat taggagttgg ttgtgtctgc aatatgaatt
    13801 ttagctggaa tggtgataag atgcaaactg cacatggtag agcttcatct acagctatag
    13861 gagttaaagt agcacttcca gatacattag taatgactta ccaaggtgat ggagatgctt
    13921 atgttatagg tctttctgaa actttaaata cagcatatag aaatcataat gtgactgtat
    13981 ttgtaataaa caataataat tttgcaatga ctggtggaca aatgtcatgg accactatgc
    14041 cgggtcaagt cacaacaaca agtgtaaatg gaagagatat aaagactact ggtagtccac
    14101 tgaaagttcc tgagatggtg gcaaacttct ttgatgtagc atatgtagca agaggttcag
    14161 ttcatagccc aaaggaaata attaatctaa aaaaatatat aaaaaatgca atagaagctc
    14221 aattaaatgg agagggatat tccttagttg aaatattagc accttgtcca actaactggg
    14281 gtgtatcact agagaaatct atcaaatgga tggaagaaga aatagtgcca tattatgctc
    14341 ttggcgaatt taagcaaagg gatggtgaat agttatggaa aaagagctag tatttgcagg
    14401 gtttggtggt caaggagttt taactcttgg tctgattgta gctgagtcag cacttgaatt
    14461 ggggaaacaa gtaacttgga tgcctgcata tggtccaact atgagaggtg gaaaagccta
    14521 tagtgtagta aagttttctg atgagagtat aggtgggcct gatatggaag aaatagatgt
    14581 tttagtagca atgaataaac catctttaga ttatataaat ttagttaaag aaggtggaac
    14641 agtagttatt aatacatctg caatagatga gaatgtaaca ttaagagaag atataagtgt
    14701 agttaaaata aattgtcagg aattagctca aaaagtaaac aatccaaaag cagcaaatat
    14761 agtagtactt ggagcattaa ttgctaaaac agggttattt gaaaaagaat tagctttaaa
    14821 aactatgtgt gatttctttg aggaaaaagg aaaaggaaag tttaatgttc aaaatgaagc
    14881 agcattcatg gaaggctata ataacgccat ttgataaatt acccttatct taagtgattt
    14941 atctcaagat ttaataatct ttagtgccaa gagaaacttc atcttgagat aaaattcact
    15001 taaaatcaca actataaaca tataggagcg tgaatttatg agtttggaaa aacttattag
    15061 accaaaaagt attgctatag taggagtgac tgataaactt ggttttggaa gaagtgcagc
    15121 acttagtata gtaaaaagta aggaaacaga tagagtatat tatgttaatc ccaaaagaga
    15181 agaattgttt gggagaaaat gttataagac gatacaagaa gttccagaag tagtagactg
    15241 tgtagtagta tgtacaccta gaaatgtagt tccatctgta ttaaaagatt ctggagagtt
    15301 aggaacaaag gcagcagtgg tatatgctag tggatttgca gaggaaggta cagaggaagg
    15361 tacagattta gaaaatcaac ttatagaaat atcaaataca tacgatatga aaatattggg
    15421 tccaaactgc atggggttgc taaattgtat agataaggtt aatctatggg caggaggttc
    15481 taaatgggat ttagatacta aaaaacctgg tataggaatt gtaggtcaaa gtggatttat
    15541 aactgctgaa attgtttcaa gtgattattt taatatatct tatggttttt caacaggaaa
    15601 tggaaatata gttacactag aagatgcagt agatttcctt gtagatgatg attatgcatc
    15661 agtaatagca atttaccttg aaggtttaaa aaatcctcaa aaatttatag atgctttaaa
    15721 aagggcagca caaaaaagaa agccagtaat aatattgaaa tcaggaaggt cagaaaaagg
    15781 tgctatttct gctgcttctc atacaggaaa tttagctggt tcgagtaaag cttttgaaag
    15841 tatttttgaa aaatatggag taatttctgt ggaaaattta gaacagttta tgtgtttagc
    15901 acaagctttt agtgttttag atggtaattt acctgcaaat tctaattttg cagcaataaa
    15961 cttctcagga ggagaaaata ctatttgtgc agatttagca gaagaaaatg gtgtagaact
    16021 tgcagaaata tcttctgaaa ctaaagaaga aatgaaaaaa tatcttccag gatttgcaac
    16081 acctaaaaat ccactagatg ctacaacagc attattccat gaaaaggata tgatagtagg
    16141 tttattacat acctttgaaa aggatgatag tgttggattt actatggtag gtgcaaatat
    16201 aagagatgaa gaaaatgaaa tgcatgaaac cctttgtaaa gctgtaagtg aagctagaga
    16261 acaaggattg aaaaaacctg tgtttgcagt tcctacactt gaaggaaata gatatttaga
    16321 ttataggact agattagaag ataatcaagt gcctataatg tcatcagttg gaactacatt
    16381 tacttgtttt aataaaatgg ctaagtttat agattatgat tattcaaaaa gaactttaga
    16441 atttaaagct gttaagaaaa gagagtcaaa taatgtagta gcattatcag aattagatag
    16501 taagattgag atgaaaaaat atggagtacc agttccagga caaggtaatg caaaaagtat
    16561 tgatgaatta gatgaaatct taaaatatat taagtatcct gttgttttaa aaataaattc
    16621 ttctgaaata ttgcacaaat ctgatgttgg aggagttaaa ataggaattg agaatagaga
    16681 tgaggcagta gatgcatata atgagatttt aactaatgta aaaaaagcaa aaccagatgc
    16741 taatattgat ggtatattag ttcaagaaat ggtagaaagt ggtatagaaa ttattattgg
    16801 tataactaat gatgaccaat ttggaccaat gttattagtc ggtttaggag gagtatttgt
    16861 agaggtattt aaagatacta cattatatcc attacctata aatcatgatg aagctattat
    16921 gatgcttaaa aaactaaaat catttaagct tttaaatggc tatagaggaa gtgagccttg
    16981 tgatattgat gctcttgcag atatgatggt caagttagga aaatatgctt atgaaaataa
    17041 ggatgaagtc aaggaaatag acttaaatcc agtgtttgta tatcctaaag gaaaaggcgt
    17101 atgtgcagta gatgccttaa tagttaaata taaatagttt ataagttttg gtattcaacc
    17161 ataattaaag caccgactga aaatcacatt ttgtaagtta gatagtgtga ttttcagtca
    17221 ccccaaattt aatttaaaaa tattttaaaa tgaaagtata gttttaagtt taattgtgaa
    17281 atagcactgt ataaacaata aaatactacg tataaaacga ataataaaag gtgttttaat
    17341 gataagaatc aatcttgatt ttcattaaaa caccttcttt attatattaa aaatttttaa
    17401 acgttatatt gtcacaggtg ggtttgttgg agctgcatat gtacgattag caaattcttg
    17461 gtcaacaaag aatagaccac cctctccagc aagtttaaca cgttttatat tgtcttcaca
    17521 atttgtttct tcttctgctt gttcagatat aaaccaaagt aagaattgag aagttctaaa
    17581 gtctgattca gagtttgcta cagctgctaa gttgtttatt aaagctgtaa cctttttttc
    17641 atgagctaac gtacgctcaa gaatatccat tgcagaagta aagtctgaat ctggcattgg
    17701 gatagcatca agctgaacct ttcctcctac attatgtaag tatttgtaaa aaaacatagc
    17761 gtggtctgtc tcttctttat attgaacata aaaccaatta gaaaatcctt taagtccttc
    17821 tgcttcaagg taagaagaca tagaaagata aagatacgca gaatataatt catggttaat
    17881 ctgctcatta agtaattttt ccattttagc tgaaatcatt tttatacctc caaattttaa
    17941 atgctcttat aaaatataat aatattaaat ggaaaaatat tcaataaaag tgtttaaata
    18001 ttttacatat ttaataaaaa tttatactac cattaaaaaa attataactt acaatggcta
    18061 tagagccaat taatggtgca tttgctccaa aatttgaatg ccttacactt atttttttat
    18121 atttagaaaa acttgctgaa gcagtcaatt tttttaataa tgtattttct ataaatgtac
    18181 caggtatatt aaagtcatag cctattatta tagaactaca atcaatcaat gtaagtgtat
    18241 taactaatgc atatgatacg tatgtacaaa attcatcaag caaaaacatg gcaagactat
    18301 ctttattatt tgcctcatct attaacttga ctaaagaaaa atctttacag ttaattaatg
    18361 gggagttagg ataaatatgg ctcaatgatt caattctttt aattagatta ctgacacttg
    18421 tataataatc taaacatcca ttattaccac aactgcacaa tggtccacta aaattaattg
    18481 atgtatgtcc tatttctcca ctttgtccta ggttgccagt atgaagttta ttttctagaa
    18541 ctagaccagc tccaatacca ttcattatgt gtaggtatat ataatttgat atatttttac
    18601 ctaaaccata cattttttct gctaatgcac ccgaattagc atcatttatc aaaaatattg
    18661 gcaaatcaga catttctttt ataaaatcta ctatatttag gtttgataca tttccaaaat
    18721 ctgggggatt tagtatggta ccatttatat catctactgg acctattgaa gaaataccaa
    18781 ttccaattat atctctcttg ttgattttca ttattttagt aaacattctt tttattatat
    18841 cttttaaaac atcatttgat agacatttgg ggtaagtttc agaaagttgt tttacaatat
    18901 taccttttaa atctgaaata attaccttac atatatttct tcttattagg attccacaaa
    18961 tacaaggcga tatattagaa atatctaata aaataggttt acgacctgat gaatgtgcat
    19021 ttaaagttga tgactctatt tccctaatca tattttcatt aataagttca gtaactagat
    19081 ttgataaagt cattttagta agtcctgtag acttagctaa atcaactctg gacataggtg
    19141 tatttgtaga aagtaatttc aatattatta acttattttt aatttttaca tctttgatgt
    19201 tagaaccttg tttgttactc atcataaatc tccttaaata aagttaagtg ttttatttat
    19261 tttcaagtat actatcacct tataatagag taacattttt ttacttgaaa atatcattaa
    19321 ttagaatata tcacattata tatcataaaa tatataaaaa aatgttagaa ttaaattaaa
    19381 agtgaaaagt agattgatat ataaatagta aatacttaat taaaaaaaga taatgatagc
    19441 aataattatt gttaccaaga atctactact tcaagtgtta ccttaggtat ttaagttgat
    19501 agtggtttgc acgtaataaa cttgatgtaa tatatattct taataatatc gataaaagat
    19561 ttacttaaaa ataatataga ttatgtaaac atataatcta tttattgtat acaataaaat
    19621 ttcattttgt aaaacagtga attaaatatg taatatagat atcgattttt attacaaatt
    19681 gttactaaat ataggtacat tagaacaaaa atctagtaaa ttgtaactaa aatgtaaatt
    19741 tttcctttaa tctatacaat attatggaaa ctttttgtaa tttatgatat aataacaaat
    19801 atataattat taaattataa taaatgacta tagcgtagat gtaatactat gttatagtca
    19861 tttttgaatt aaacttgata tatcaagggg gaagaatatg agaacaatta gaagagtttt
    19921 agcattaggt ttaacattag ctatatttct aataaatgta cctaatgtag atgcattaac
    19981 atcagataca attaaaggta acaatatata tgagacggct ggattaatag cagataaaaa
    20041 gagttatgat acagcaatta tggtaaatat ggataattct atagcagatg gtctttcagc
    20101 aagtggtctt gcaggtgctg ttgatgctcc aattttgctt gcacaaaaaa ataagatacc
    20161 aaatgaaaca aaacaaagat taaaaaatgt taaaaagata tacataatag gtaaagaatt
    20221 atcaataagt aagtcagtag aaactgaact aaaaaacaca ggggcacagg taactagatt
    20281 gggtggagat gacagaataa agactagtta tagtgttgct aaagaggtaa atggtatcaa
    20341 aaaagttgat gaagtgatat taactaatgc atataaagga gaagcagata caataagtgc
    20401 tgcacctgta tcagtaagag atatagctcc tatagtactt acagatggaa agagtgtacc
    20461 tttttcaaca agcaatgtaa aaacatatgc agtaggtggg agtatatcaa tgagcactag
    20521 tttagttaat aaaactaatg ctaaaagact tggtggttca gatagatatg atacaaataa
    20581 gaaagttata aaagagtttt atccagatgc atcagaattt tatttgagtg atggatatga
    20641 tttagtaaat gcacttacag gttctacaat tgctaaggaa aatccaattg tattggtgtc
    20701 agaaagtagt gataagtcta tattagcagg agcagataag attactagat taggttcaat
    20761 aagtgacagt gtgtataata agtgtgtttc tgctgcacaa aataatggcg attcgtctac
    20821 aaaaggtgag tcacctatga aaaatgagac aagcatatta ggtcagccaa cagctagttt
    20881 agaagcgtgc ttaaaatggg caaaatctaa aaaagctaat gatttattta tagagttaat
    20941 accaatatta tatgatactg ctgttcagga aggtgttaat cctgttttgg cagtagctca
    21001 atctgcaaaa gaaactggtt tttgtaattt tggtggagta ttagatgcat catttaagaa
    21061 tccttgtgga cttaaaactt ctgtaggagg ttctgatact gataagaatg cccattcaag
    21121 atttgatact tgggaagaag gaatattagc tcaaattcaa catttatgct tatatgcagg
    21181 acaagatggt tacccacttt caaatccagt agaccctaga catgaaaaat ctttatttgg
    21241 taaggctaaa acagttgaaa gtttatctaa taattgggct ggaggtcaat atggacaaga
    21301 tttagtaaga atgatgggag aaattgaggc aacaaaataa ttgaagatta tcaaatatcc
    21361 aataaataag gattgattat tatgaaaaag agtaatattt ttagtatcat atttcctaca
    21421 gtcataatgg tgctaatgtt tttaactttt gctacagata tatttaatat tccagatatt
    21481 caatctaaaa gtatttttgt tgtgggaatg gttttgattt ttccaatttc ttttttgata
    21541 caagggataa tttgtgtatt aaataagact aattggattt tatctcttat tgtgtcttta
    21601 gtaacttata tagtattaat gtatatattt ttaaatgatt ctgcatatat atatgtttta
    21661 ctttatacag ctttttatat gattggacat ataacagcta aactctatta caaaattaag
    21721 acttttaaaa attaaattga agtatataaa agtaacatta ggagaagtat ccttaatgat
    21781 tttctaaaat cagaaatagg tgcttctctt ttttgtaaaa ataaaagtat gtaaataaaa
    21841 tttaaccatt ataattttct tttaacaaat gtatacaata aacttgttgt ataattaaga
    21901 tagataaaat aaagggaggg ataatatgaa tttaatagat aatcatattc atactaattt
    21961 ttcaagtgat ggaaaggatt ccatggaaga tacaataaaa aaagctataa gtattggtgt
    22021 tagatatttg acttttacag accatttaga acatgatgaa gatagaggat tttgcataaa
    22081 ttataatgac tatgttccag tatttaataa gtttaaagaa aaatataaaa aggacataga
    22141 gttattacta ggtgttgaag tgggttacag aaaacatcta aaaaatgaaa tagaagaaat
    22201 aataaattct aatccttttg attttgtatt gtgctcaact catacaattg acaatgtacc
    22261 tgttccatca aaggagtatt ttaaaggtct tagcaaagaa gatgcgtatt ataaatattt
    22321 taatagcata cttgaaacta atcgtgaatt tggagattac aatatatatg gtcatttgga
    22381 ttatatatct aggtatggaa tatattcaga taatagagtt atatacaatg actttaaaga
    22441 tgttattgat gaggtcttaa agtcaataat caataatggg agtggtatag agctaaatac
    22501 ttctggttat agatatggat taaatgctat acatccaaat gaagatattc taaaaagata
    22561 taaagaactt ggaggattta tagttactgt aggttctgat tctcataggg tagaagatat
    22621 atgtaaagat tttgatgtgg cctatgatat gcttaagtat cttgacttta aatatgtatc
    22681 tttatttaaa gaaagagaaa cttattttgt aaatatagaa aaagttaaat ctaacaatat
    22741 agcttagagt gtgttttgaa gtaaattaat ggatagttaa aaagttaata gttataatat
    22801 tgtatcctct agaaaaatac tagaggtttt tattttgcta aaataactaa atagaattaa
    22861 atttaaatag tatagtttat tttaaattga atagtttatt gttgatatat tttactatta
    22921 tatattttta ttgtgatata atagtaaaat atattaacct atctttagat tatataaatt
    22981 attataaagg agggaaattt taaaatgtct aataaaaata aagaaaatat aactttaagt
    23041 aatcaaatca aaggaacaat tcaaaatagt ttaacaaaag aagctatatt acatatacca
    23101 atgagcaatt atgcctatgg ttatgataga gaaacactac atataagact tagaactaaa
    23161 aaaaatgaag cgaaaagagt aattttacga ataggagacc aatatgtgtg ggataaagga
    23221 ggtgcaggag gaggaaattt aaatgcatct ggagttggtt ggtctggtgg aacaaatata
    23281 gtaatgagta aagaagtaga aactgaatta tttgactatt ggatagctaa gtgtaagcct
    23341 ttaaataaac gctcacgata tggctttata atagaaggtc aagaggaaaa acttttattt
    23401 acagaaaaaa gaataataga gttgggaaat gaaaatgatg aaaaggaatt atgtgaaata
    23461 ggtaattttt ttggatatcc atatttaaat tatatagata tacctaaagt gccaaattgg
    23521 gtgaaagata ctgtttggta tcagatattt ccagatagat ttgcaaatgg tgacccgtct
    23581 ataaacccag aaggagtaga taaatgggga gctattccaa ccagagataa ttttacaggt
    23641 ggagatttac aaggtgtgat agaacactta gattatttga gtgatttggg aataaacgga
    23701 atttactttt gccctattac aattggaaaa accaatcata gatatgatac ggtagattat
    23761 atggaggtag accctacatt aggagataaa gagactttaa aaaaactaat agaagaagcg
    23821 cataagagaa atataaaaat aatgttggat gctgttttta atcatatagg atattattct
    23881 aaacagtggc aagatgtagt tcaaaataag gaaaattctc gatataaaaa ctggttttat
    23941 ataaaagata tgagtaaaat tgatactcca atagaacaaa tagatgaaaa aaatatacct
    24001 tatgaaacct ttgggtgtga aaaatatatg cctaaactta atacagaaaa ttcagaagta
    24061 ataaaatatt tattggatgt aggcaagtac tggatacagg aatttgatat agatgcgtgg
    24121 agattagatg tttcaaatga agtagaccat gttttttgga gaaagtttag agaagaagtc
    24181 aaaaaagtaa aaccagacat ttatatattg ggagaaattt ggcatggtag tttaccatgg
    24241 ctaatgggtg accaatttga ttcagttatg aattacttga tgtcagaagc catgaaaaaa
    24301 ttcttttgta cagatgagat aaacgccgaa gaatttaagt atatgataaa tgatgtaatg
    24361 gtaagttatc caatacaagt tagtgaagtt atttttaatt tacttggaag tcacgatact
    24421 acaagaatat tgacttatgc taatggaaat attgatagat ttaaacttgc atatatgttt
    24481 atgtttgtac aaacaggatg tccttgtata tactatggtg atgaaatcgg aatggaagga
    24541 gaattaagtt caatatctga aggtcaaaga aaatgtatgg aatggaatga agaaaaatgg
    24601 aataaggata tatttgattt tatgaagaag attattagac ttcgtaaaga aaataaagaa
    24661 cttaggtcta tatcaaatga atgggtgtta gcagataagg aaaatggaac gattatattg
    24721 aaaaaagaat ctatttctat aataataaat aattcatcta aaaatataat tttgacgtta
    24781 ccagattatt tagcaaataa aaaagtaaaa gatttatatg aagaagaaat agttgattta
    24841 aaagaagaac taatgttaga gaaatacaag ttcattattt taaaat
//
LOCUS       DAEPID010000057        24463 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.057, whole genome shotgun sequence.
ACCESSION   DAEPID010000057 DAEPID010000000
VERSION     DAEPID010000057.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 24463)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 24463)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..24463
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.057"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            complement(375..551)
                     /locus_tag="KR257_002581"
     CDS             complement(375..551)
                     /locus_tag="KR257_002581"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897136.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0031263.1"
                     /translation="MFIGEIDKCTHILTAYISSSYDYCNFLDTQLDDFISEYGETVVE
                     TCLHQVLLLVSRYN"
     gene            1126..2148
                     /locus_tag="KR257_002582"
     CDS             1126..2148
                     /locus_tag="KR257_002582"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893219.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0031264.1"
                     /translation="MVNWEIKKLAKSKSMFISLGILVLILMISIFITPVLETESYYID
                     KEKGRIEDTRSGIDIGNEKFQNKINVLKQFSNQTDTGEFSKKIELMSKKKLDNLSVNE
                     YKDISFWKVFNYRVTNSLINVGMLIIISIIISNIYVDEVVTSVKDIILSSKEKKKALN
                     SKIFVALLVPLVIYSVYLMGIFIITCMQQGVPVNGDLESFRIVDNVVALKTNLSITKY
                     VILNIGIELLMFEGWAMIAIFGSFISKSSISSISFFIFIISITKIMSVIHILPKKLLS
                     VVSNVNYYDLIFGFNKIIGNYLGDIMIFKVNIDIVNIAIGLLMAILIGAMSLCFLVIK
                     SDYISR"
     gene            2162..3049
                     /locus_tag="KR257_002583"
     CDS             2162..3049
                     /locus_tag="KR257_002583"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011948651.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBH0031265.1"
                     /translation="MNKLEIENLSKIYGKKVANDKITVTLENGVYGLLGPNGAGKSTL
                     MKQITTLIKPDEGQILYNGEDIFKMDADYRNILGYLPQEFGVYKNFTAKEFLQYIGAL
                     KGLRGKYLNSKIGELLDLVGLYDVRNKSIGKFSGGMKRRAGIAQVLLNDPKIIVLDEP
                     TAGLDPQERARFRNLIAKMSRDKIIILSTHIISDIESVAKETIMIKDGKLLMKGTHKD
                     ILSHMENKVYNVQVKNECEVDDIQSKYKVVSIQSDINSIVLRIVSEDIPSEDNIQPVQ
                     AKFEDVYMFYFDLEDAREV"
     gene            3055..3828
                     /locus_tag="KR257_002584"
     CDS             3055..3828
                     /locus_tag="KR257_002584"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896816.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBH0031266.1"
                     /translation="MMYLVKAEMIKILKSKSVWIIWLFLIFFGFFLIRKFDVLDTYAD
                     IFYKIEGSIPLIGLIMFIITSGNYIKEYDSNMTGLINTTKKGKKSVVLSKLVANGLIL
                     SIINISFILLVGIRGFSFFDFKNLNESIHNLWYFGNSNLNLTVIQMYIIVILTTIFAS
                     FIFAQIGLTLSSIFKSAVIPFILGGLIMAIPYFSVGFIPDKAIKFMSVTPNWIMMSQQ
                     MVKYNVPSILIVFSIVISIILMIVLTKITYENFTSSKRF"
     gene            3940..4665
                     /locus_tag="KR257_002585"
     CDS             3940..4665
                     /locus_tag="KR257_002585"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012450879.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HBH0031267.1"
                     /translation="MENRVLIIDDEVEILKLLETVLKKEGLNNIYTAKTKKEGLELFK
                     SINPDLIVLDIMLPDGEGYDICKEIRKTSNSPIIFLSAKTEELDKLLGLAIGGDDYVT
                     KPFSPKEVAFRVKAHLRRLSYFSDAQNESKNLNNNEEKIISFGPYILNESRAELIKDG
                     KSIGLFAKELKILSLFAHNQNQIISKEKLWDKVWGEDYVGFDNTIMVHIRKIREKLED
                     NPSKPEYILTIKGLGYKLAVKED"
     gene            4669..6072
                     /locus_tag="KR257_002586"
     CDS             4669..6072
                     /locus_tag="KR257_002586"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729569.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HAMP domain-containing histidine kinase"
                     /protein_id="HBH0031268.1"
                     /translation="MKWKITRNFIFTIVFVAISVVIINIISILYVISTNSFFKVVDSG
                     NNPEEFARSFEKDLYEKDGEFKLSKIGAEKLEKSNSWIQVLNDLGEEVYGVNVPKDTP
                     KKYTPFQMVNNYKYIETKYVNFVLEKYLNKKHLNIIVGIPSRDISRIILTYSQNNIKK
                     TLNKVIIITLVIDSVVALGVGYLFSRKLTKPISSVLWSIETMANGNYSLYLKDRGIYE
                     EVFKNINMLADTLRVNEVERKENEELREEWLANITHDIKTPLASIQGYAEIINDKDYE
                     FEEDEIQEYTEIIYNKSKYIKDLVDDLNLSTRLKNNTIVLDKKKINLVSLVRDIIIDI
                     LNDNRYKNRNIEFESNEDLIEVYVDSILFRRAITNLIFNSIVHNSEGTLISVEIVKKD
                     NIEIIIKDNGIGISKSDLKHIFKKYYRGTNTGEMHKGSGLGMAISKEIIEIHKGKIYV
                     SSEIGIGTKIIIEIKQN"
     gene            6083..6907
                     /locus_tag="KR257_002587"
     CDS             6083..6907
                     /locus_tag="KR257_002587"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729568.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="conjugal transfer protein TraX"
                     /protein_id="HBH0031269.1"
                     /translation="MDFFKKGISGFTIKILALIFMTFDHIAAFMPQTMQIPIWFHWVG
                     RISAPLFIFMAVEGFYHTSNRKKYISRLYIWSVIMAIGNQIINNVFSHPEGAIIINNI
                     FSTLFLIAIYLQAIEFIKKFRKEKEIKYFIIGLLMIIIPIILGIFTVALLFKVTNRVI
                     ALFMILVPVPFLVEGGPIWIILGIIFYLCRGKKFSLSICYVLMCIFIFTTMSNGDYSL
                     KNSILQNYQWMMIASLPLMLLYNGEKGKSMKYLFYLYYPIHVYILYILGIYLINGF"
     gene            complement(7232..7852)
                     /locus_tag="KR257_002588"
     CDS             complement(7232..7852)
                     /locus_tag="KR257_002588"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454488.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flavodoxin family protein"
                     /protein_id="HBH0031270.1"
                     /translation="MKVLLINGSPNQYGCTYTALNEITKVLSKHDIKTEILYLGKETI
                     PGCISCASCFETGKCIRNDKVNKLIEDLDNIDGIIIGSPVYFSSATGQLTSFLDRLFF
                     IAGSRMATKLGASVVSCRRGGASATFDQLNKYFSISNMPIVSSQYWNQVHGFTPEDVM
                     KDEEGLQTMRTLGENMAWLLKCISAGKKAGIKEPQYEETIMTNFIK"
     gene            8118..8450
                     /locus_tag="KR257_002589"
     CDS             8118..8450
                     /locus_tag="KR257_002589"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420359.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HBH0031271.1"
                     /translation="MSIDCISNTDLSETGFSYTLSLISGKYKMIILYCLVEFEVVRYN
                     ALKRYINTISYKTLSLSLKELEADNLIIRTEYPQIPPKVEYSLSERGKSLIPILDAMC
                     EWGERNRP"
     gene            complement(8570..9211)
                     /gene="pcp"
                     /locus_tag="KR257_002590"
     CDS             complement(8570..9211)
                     /gene="pcp"
                     /locus_tag="KR257_002590"
                     /EC_number="3.4.19.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420360.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pyroglutamyl-peptidase I"
                     /protein_id="HBH0031272.1"
                     /translation="MKILLTGFDPFGGEPINPAQEAVERVNNNINGAEIIKITIPTVM
                     TKSVEAIDKAIQEHNPDIVISVGQAGGRFDITPERVAINIDDFRIKDNEGNQVIDTII
                     KEDGEPAYFSKLPVKAMVKHMNENKIPASVSNTAGTFVCNHVMYGILYMIDKKYPNIR
                     GGFIHIPYTTSQVIDKKNTPFMSLEEIVKGLELAIEACIIYKEDVKEIGGEIS"
     gene            complement(9232..10164)
                     /locus_tag="KR257_002591"
     CDS             complement(9232..10164)
                     /locus_tag="KR257_002591"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430140.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF979 domain-containing protein"
                     /protein_id="HBH0031273.1"
                     /translation="MQNFINISLEIFYALMGFLMIVIAYKSFTTINNNKKYGTSLFWI
                     LISLPFIFGRLIPANIIGIILILSSLLTLSKQVVFAKYEEPDENFGKEQADKLKNKIF
                     IPSLILAFAAVVVAMSLSNFDNSSQFAIGVGSIIALISALIITKAKPATSVQDGSRLL
                     QQMGPASMLPQLLVALGALFTQAGVGEVISTMISGVVPADSRLFGVIAYVLGMVIFTM
                     IMGNAFAAFSVITAGIGIPFVLSQGGNPAIIGALALTAGYCGTLLTPMAANFNIVPAA
                     LLECKNDYIVIKYQAPVALVLIIAHILVMYFLGF"
     gene            complement(10186..10851)
                     /locus_tag="KR257_002592"
     CDS             complement(10186..10851)
                     /locus_tag="KR257_002592"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889567.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF969 domain-containing protein"
                     /protein_id="HBH0031274.1"
                     /translation="MIKLIGILIVVIGFILKIDTLFTVLLAGVATGIVAGLDFNQIFT
                     ILGDSFVSNRGVSLFILTLPVIGVLERYGLKQRAVSLIEKLKRLTTGKVLTIYMIARQ
                     IAGALSIRMSGHPQFVRPLVNPMAQAAGLSNSDELKESDEEAIKALSAASENYGNFYG
                     QNLFAGSSGVLLIASTLTQFGYNVTGLNIVKASTIMAVIALVVATIQFTLYDKKLNKS
                     HKK"
     gene            complement(11421..11894)
                     /locus_tag="KR257_002593"
     CDS             complement(11421..11894)
                     /locus_tag="KR257_002593"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889569.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flavodoxin"
                     /protein_id="HBH0031275.1"
                     /translation="MNTIIIYSSKYGCTKDCANILKNKLSDNVTIVDINNNNKIELSK
                     FDKIIIGSSIYVGSVSKKIQVLCNDNVELLNKKQVGIFLCCGFSEQADKYLKSNFPSS
                     LLESANAIGIFGSEARLEKMKFLDKLIMKAVSKGNYDSFRISQDNIDNFLINLNS"
     gene            complement(11897..12301)
                     /locus_tag="KR257_002594"
     CDS             complement(11897..12301)
                     /locus_tag="KR257_002594"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430146.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="FMN-binding protein"
                     /protein_id="HBH0031276.1"
                     /translation="MKIRNKATNKKKKYVKISIALFFVFICIIIVIVSNLKPENLVVK
                     DIDINNVKNGIYTGSADNNLVKATVSVEVNNGKIQNINILKHDHLLGKPAEKITTSII
                     KQQSLDVDAITSATYSSNTIRKAVENALRKGE"
     gene            complement(12276..12905)
                     /locus_tag="KR257_002595"
     CDS             complement(12276..12905)
                     /locus_tag="KR257_002595"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454480.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="HBH0031277.1"
                     /translation="MSIKERRKNEKEEMKKKIMDASIEIINQHGYENLSIRKIATKIE
                     YSPTTIYLYYKDKAEIISDMTNKLYNTVESNAIDIMNNCSSLPIDKQIIEIMTSFIKT
                     LSSEPEMAKSIMYSRMNIIFASENTNNTPSNNGIKMLDKFLSIGIEQGIFKKNIDKSS
                     WMLISALLGFVLCVVENKLYSLHNFSQLIENFLDILVGGLYNENSQQGY"
     regulatory      13270..13313
                     /regulatory_class="riboswitch"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00522"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="PreQ1 riboswitch class I; Derived by automated
                     computational analysis using gene prediction method:
                     cmsearch."
                     /bound_moiety="preQ1"
                     /db_xref="RFAM:RF00522"
     gene            13414..14382
                     /locus_tag="KR257_002596"
     CDS             13414..14382
                     /locus_tag="KR257_002596"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430148.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nucleoside hydrolase"
                     /protein_id="HBH0031278.1"
                     /translation="MEKRKVIIDCDPGIDDSLAILLALNSPELEVIGITTCCGNVPAN
                     IGAENALKTLQMCSSLNIPVYIGEEAPLKRKLVTAQDTHGEDGIGENFYQKVVGAKAK
                     NGAVDFIINTLYNHEKVSIIALAPLTNIAKALIKDKKAFENLDEFVSMGGAFRIHGNC
                     SPVAEFNYWVDPHGADYVYKNLSKKIHMVGLDVTRKIVLTPNIIEFINRLDKKMAKYI
                     TEITRFYIDFHWEQEGIIGCVINDPLAVAYFIDRSICKGFESYVEVVEDGIAMGQSIV
                     DSFNFYKKNPNAIVLNEVDEKKFMYMFLKRLFKGYEDIIDSVEGVI"
     gene            14384..14947
                     /locus_tag="KR257_002597"
     CDS             14384..14947
                     /locus_tag="KR257_002597"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420367.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ECF transporter S component"
                     /protein_id="HBH0031279.1"
                     /translation="MKRKICVKTITLIAFGISINIIGAFIAMGLRLPVYLDSIGTIMI
                     ASLLGPKYAVVTGVFGSLISGITFDVYSLYFAPVQISTGLLAGIAFKKNFLRGLKTPL
                     GVLLFAIPTSIISSIISAFLFGGMTSSGSSYIVQILKVLGLGDVFSVFVTQVFTDYGD
                     KLLAVVLVNLGLNAVPKTLKVSLTGGK"
     gene            14955..15644
                     /locus_tag="KR257_002598"
     CDS             14955..15644
                     /locus_tag="KR257_002598"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889578.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="radical SAM protein"
                     /protein_id="HBH0031280.1"
                     /translation="MDRYSEITNKNQREIVLLKGFPCIWGKCSFCDYIDDNSNLEEEM
                     NKLNLKVLKNVTGKYGVLEVINSGSCFELPKDTLEKIKCIIKEKNIKKLFLESHWSYK
                     NRLKEMREYFEIPVVFKIGVETFDNDFRNNILNKNANFKTPQDVKEYFDSPCIMVGIK
                     GQTKEMIDKDIEIILNTFEKATVNVFINNSSSIKRDEELVKWFVSKYKFLDENPNIEV
                     LYNNTDFGVGD"
     gene            15771..16499
                     /locus_tag="KR257_002599"
     CDS             15771..16499
                     /locus_tag="KR257_002599"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018112775.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA alkylation repair protein"
                     /protein_id="HBH0031281.1"
                     /translation="MMFDRVKWNKLDYNELLEYMMSIQDIKYRDFNKKLIPGTENIIG
                     IRVPNLRKLSKEISQGNWKEFLEVAEDTYYEEVRLQGMVIGNINSNFEETLYYVKRFI
                     PKIDNWSVCDGFCSDLKSMKKYKENMYDILKKYVYSKNPWEIRFALVMFLIYYVDDKH
                     IKEIFEYCNNIQSEEYYVKMGMAWLLSICFIKCEEETFLYIKNNNLDDFTYNKMLQKI
                     IESNRVDLEKKNIIRSMKRKTRRC"
     gene            16513..17187
                     /locus_tag="KR257_002600"
     CDS             16513..17187
                     /locus_tag="KR257_002600"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454475.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA-binding protein"
                     /protein_id="HBH0031282.1"
                     /translation="MNNNEDRIDKFLELQSKGFKFAEIAQNLKISQSTLRTFLNKKGY
                     KSEKGKYIFKDELNYNKSLDNRNLEEEKAKEYEKSKKNTISNRKKVSTKKKISNEKAL
                     SKSVEQIEFNDTGLKNAKPKQNIKPKKDRKINITQEDLDKLCEVYDWYLEVKDYNIKP
                     KKVSNKKDVHIDDEHIDELKTTRIRIDKEIWNDFERLCSNSNFEKHQILTQALKEFMK
                     KYKNLL"
     gene            17213..18049
                     /locus_tag="KR257_002601"
     CDS             17213..18049
                     /locus_tag="KR257_002601"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454474.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0031283.1"
                     /translation="MNKIVKKSISLMIILTIFIFMLTACEKDEQPDSVDIQTEDKNEI
                     KIDEGNAKVLNIGKSEIINIDEGDKVDTSTKVENNSTFNISNVELIYNEYDENKKIIS
                     SDSKALLDMTLMPGKVAYIECGHKTFVKGVEVYAYEYEAEGKIVYVNLKENTINIRNN
                     NIKLENSSQYEVLSTSELKKVNESNEGITYQVKVKNSSSKDLGNIILKTAEVNENGEY
                     LTVNRVPSYKILKPSEETDIDILCSTKAKSVEIVGYTYDDIKEKANVDIDLKSHKVKI
                     DK"
     gene            18065..18736
                     /locus_tag="KR257_002602"
     CDS             18065..18736
                     /locus_tag="KR257_002602"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729560.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HBH0031284.1"
                     /translation="MKVLIVEDNKILLESVVEELSKHFETEKCEDGEEALYLVNQNIY
                     DLVILDLMLPNINGFDILKKMRVNNIDTPVLILTAKETLDDKVEAFTIGANDYLTKPF
                     YMEELVARVYAILRTNGKIKERNGLEFKSLYLDTLEKRVYIEKEEIKLQNKQFNLLEY
                     FVLNKGSILLKEQIYDRIWGIDSDATIEIVEVYVSNLRKKLSKYGYDKYIKTKRKVGY
                     IFDDK"
     gene            18726..19958
                     /locus_tag="KR257_002603"
     CDS             18726..19958
                     /locus_tag="KR257_002603"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430155.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HAMP domain-containing histidine kinase"
                     /protein_id="HBH0031285.1"
                     /translation="MINKNVFTSTKNHLIKMYIIVVGSFLIIFSIFIYSYFRGLTYSG
                     IDSEINDELEYIVSQFKRTSFLNPIRLKDPKDMVYVYEDGRISYYTQNEYFDELLPDR
                     RLDKKNSFFKYTENGYTFRELNVDVGRYQIQIIRNIDSEMNSLRQLTSVLIIGILISV
                     IITYFVAVYLTRKALIPIETAWKNQAKFIQDASHELRTPITIVSSKLESMLKSPESTV
                     NDEVETIATAMKETRRLKKMITDLLSLTKEDSIVKVNLEEIDLEKLLEEISEDYIDIA
                     EFQEKRFVFNSKLKNKVIITDKNKLRQLILIFIDNAFKYTKLGDEIALELKEDIEDEV
                     TLLISDTGIGIKKEEIPLIFDRFFRSENVRNKDLEGSGIGLSIARMISLNLSIDINVT
                     SDVDIGTTFELSIPKKLK"
     gene            20108..20425
                     /gene="trxA"
                     /locus_tag="KR257_002604"
     CDS             20108..20425
                     /gene="trxA"
                     /locus_tag="KR257_002604"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420374.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="thioredoxin"
                     /protein_id="HBH0031286.1"
                     /translation="MAKVINTSEFRSSVEGSKGVVVVDFFATWCGPCNMLGPVFAELG
                     EEMKDKARFVKVDIDESLEIAQQFNVSTVPTMIIFKDGKPVETLIGFMPKNKIEMQVK
                     SYL"
     gene            20442..21320
                     /locus_tag="KR257_002605"
     CDS             20442..21320
                     /locus_tag="KR257_002605"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430157.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NAD(P)/FAD-dependent oxidoreductase"
                     /protein_id="HBH0031287.1"
                     /translation="MRYDIAIIGSGPAGLSAAINAKIRNKTIIMFGNDNLSNKLVKAP
                     SIDNYLGFYDISGDELKDKFKSHIDSMDISIENKRINNIYAMGEYFTIMSGNDMYEAT
                     TVILATGVEYTRPIKGEEEFLGRGVGYCATCDAPLYRNKKVAVIGYNEESKEEANFLS
                     ELTSKTYFIPMYKKDNLMRSSDNLDDSIEVIHDRPVQIDGDKLVNKVSFKENHIEVDG
                     VFVIKDSTAPSALVPGIEIDGIHIKVDNNMKTSIDGCFAAGDCVGKPYSYIKAAGQGQ
                     IAALNAVYYLDKLKRA"
     gene            21590..21958
                     /locus_tag="KR257_002606"
     CDS             21590..21958
                     /locus_tag="KR257_002606"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420376.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="winged helix-turn-helix transcriptional
                     regulator"
                     /protein_id="HBH0031288.1"
                     /translation="MENLVKIFKALSDETRLNILILVSKRNICQKGISKYLGISDSAV
                     SQHIKILKDVGIITGYKEGYYVLYHINKESFNICVDFINSMLSNSSESFIDVFDVNTI
                     HLGCSKECKSIKKCCKRREK"
     gene            21961..22332
                     /locus_tag="KR257_002607"
     CDS             21961..22332
                     /locus_tag="KR257_002607"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420377.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NifB/NifX family molybdenum-iron cluster-binding
                     protein"
                     /protein_id="HBH0031289.1"
                     /translation="MKVCIPVEENKGLDSKPYGHFGSAPIFVVCDLESGEVKSLDNGD
                     LDHEHGKCQPLKALSGTAVDAVVVGGIGQGAIIKLNGMGIKVYRAEGDTISANLDLLK
                     NGKLVEFPSDHTCSHDGCGHH"
     gene            complement(22477..22932)
                     /locus_tag="KR257_002608"
     CDS             complement(22477..22932)
                     /locus_tag="KR257_002608"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430160.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0031290.1"
                     /translation="MNINTVQGDSIEVLLRQLGATRISKVSSTLYFIKFDLGDGWEIS
                     YTYNINAKDQYFLQRIEPYPIGRGLFNDEYEIVSFISKDLKKFLNAKNSSNFKTFVEV
                     TRKVNSIIDNVEELFLNYNVDGDDLKTLNKELNDILNDIDYIEKHTKKI"
     gene            complement(22971..24236)
                     /locus_tag="KR257_002609"
     CDS             complement(22971..24236)
                     /locus_tag="KR257_002609"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430161.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ArsB/NhaD family transporter"
                     /protein_id="HBH0031291.1"
                     /translation="MEFQQIIAICIFLIVMAAIITEKVNRSVAAVGGALLMIIFNILT
                     LDEGLSHIDFNTIGVLVGMMLFVAVVKNSGLFEYIAIWTAKKAKGDPWKIMICFAIIT
                     AILSAVLDNVTTVLLIGPMTIVITQILGLNPVPFLITQILASNIGGTATLIGDPPNIM
                     IGSAANLSFMDFVINLGPAVIVILAITIICFRFIYGKELVVNERAKNAILKLDEKKSV
                     KDKPLLIKSLILIAFILFGFMFHSTIHIDSSVVALTGASIMLLIGKQDVDEIMAGIEW
                     STILFFMGLFVVVGGLVEVGIINKLAQALIGLTEGHLVFTMLLILWLSAIVSSFLDNI
                     PFVATLIPLILTMQAEGIDVMPLWWATSLGACLGGNGTLIGASANVVLAGIGNKHGHP
                     ISFKEYFKIGFPLMIISIIISTVYLIIKF"
BASE COUNT         9453 a         2712 c         3773 g         8525 t
ORIGIN      
        1 cagttgatat tgaatattct aaatattggt gttattttat aggtggttta aacatattag
       61 ggggatttta tatatgattt gtatgattta tagagaatgt ataaaatagt aaaggtttag
      121 agccatgttt agtggattgc agaatatgca tatagaatga ttcttgtaaa ttaagttaga
      181 cataggaaat atataatttg tattggatga ttaattttat ggtgtatgct tttaacttct
      241 ataatgggaa agtaaagatg tactcccaat acatctttac tttagcagaa gttatagtta
      301 cttataaagt acaaaaaatt atatatttat tagagtagat aaatctaaaa aggtttttct
      361 agaaaaattt agttttaatt gtatctactt actaataata agacttgatg taagcaggtt
      421 tcaactaccg tttctccata ttctgatata aaatcatcta actgtgtatc taaaaaatta
      481 caataatcat atgaactact gatgtaagca gttagtatat gtgtacattt gtctatttct
      541 ccaataaaca tattatccat ccccctaaaa aatttagtaa aaataaaaag tcgcattcta
      601 ttagtcaatt aacataattt ataaaatttt ttagtactag tttctataac ttaactcctt
      661 aaggttaaat attcccagtt ttaccaattt agttttattc tacaagtata taatactaga
      721 agatgcttca ttattcaaca tgcttgtttg agaatagaaa atattctaaa attataattg
      781 tttttaaaaa taagattcaa gataaataaa gttatatgca actatttaat aatctttcca
      841 taataaggac agtaggttct attcttaaaa aactccatct ttaaatttaa agaataacta
      901 caatttgaac aacaataaaa tttccaatca ataaaaatat caaaaataat aaaaataatt
      961 gaaaatgtat aatttcccag aaaaataata aatgtaactc caataataaa cacacctata
     1021 aattataaaa taatttaagc tttatttaag gttagtatta tatttatata agatttaagt
     1081 tttaatatat atgtgtaatt aaaatgattt aggaggagaa atatattggt aaattgggaa
     1141 ataaaaaaat tggctaaatc taagagtatg tttatatctc taggcatatt agtgttaata
     1201 ctaatgatta gtatctttat tacgcctgtt ttagaaacag aaagttatta tatagataaa
     1261 gaaaaaggac gtatagaaga tacgagaagt ggtatcgaca taggtaatga gaaatttcaa
     1321 aataagatta atgttttaaa gcagttttca aatcaaacag atacaggtga attttctaaa
     1381 aaaattgaat taatgtcaaa gaaaaaactt gataatctaa gtgtgaatga atataaggat
     1441 attagttttt ggaaagtatt taactataga gttacaaatt cacttataaa tgtaggaatg
     1501 ttaatcatta tatctataat tatatctaat atttacgtag atgaagtcgt tacttcggta
     1561 aaagatatca tactatcatc aaaagagaag aaaaaagcat taaattctaa aatatttgtt
     1621 gctttattag ttccattagt aatttattct gtttatttaa tgggaatatt tattataact
     1681 tgtatgcaac aaggagtacc tgttaatgga gacttagaat cttttagaat agtagacaat
     1741 gtagttgcat tgaaaactaa tttaagtata acaaagtatg taatattaaa tataggcata
     1801 gagcttttga tgtttgaagg atgggccatg atagccatat ttgggtcttt tataagtaag
     1861 tcttcaatat cttcaataag tttttttata tttattatat ctataactaa gataatgtcg
     1921 gtaatccata tattacctaa aaaattactt tcagttgtat caaatgtaaa ttattatgat
     1981 ttgatatttg gttttaataa aataatagga aattatctag gtgatattat gatatttaaa
     2041 gtgaatatag acattgtcaa tatagcaata ggacttttga tggcaatatt gataggtgct
     2101 atgtcattat gttttttagt aataaaatca gattatataa gtagataaaa ggggagttaa
     2161 gatgaataaa ttagaaatag aaaatctttc aaagatatat ggtaaaaaag tagcaaacga
     2221 caagattaca gtaactctag aaaatggagt ttatggtctt ctaggaccaa atggagcagg
     2281 aaaatctaca ttaatgaaac aaataacaac gttgataaaa cctgatgaag gtcagatact
     2341 ttataatggt gaggatatat ttaaaatgga tgctgattat agaaatattt taggatattt
     2401 gccacaagaa tttggagttt ataaaaattt tacagcaaaa gaatttttac agtatattgg
     2461 agctttaaaa ggtttaaggg gaaaatattt aaatagtaag ataggagaat tattagattt
     2521 agtaggtctt tatgatgtga gaaataagtc tataggaaaa ttttcaggag gtatgaagag
     2581 gagagctggg atagcacaag ttttactaaa cgaccctaag ataatagtcc ttgatgagcc
     2641 aacagcaggt cttgacccac aagaaagagc tagatttagg aatttaatag caaaaatgtc
     2701 tagagataag ataataatac tttctactca tataatttcc gatatagaat cagttgcaaa
     2761 ggaaacaata atgattaaag atggcaaact cctaatgaaa ggaacacaca aagacatatt
     2821 aagtcacatg gaaaataaag tatataatgt tcaagttaaa aatgaatgtg aagttgatga
     2881 tatacaatct aaatataagg ttgtaagtat tcaaagtgat attaattcaa tagtacttag
     2941 aattgtttca gaggatattc caagcgagga taatatacaa ccagttcaag caaaattcga
     3001 agatgtatac atgttttatt ttgatttaga agatgcaagg gaggtgtagt agaaatgatg
     3061 tatttagtta aagctgaaat gataaaaata ttaaaatcaa agagtgtttg gataatttgg
     3121 ctgtttttaa tattttttgg attttttctg attagaaagt ttgatgtttt agatacttat
     3181 gcagatatat tttacaagat agaaggctca atacctctaa taggtttgat aatgtttata
     3241 ataacttctg gaaattacat taaagaatat gattctaata tgacaggttt aataaataca
     3301 actaaaaagg gaaaaaaatc agtagtatta tcaaaactag tagctaatgg attaatttta
     3361 tctattatta atatttcttt tatattgtta gtaggaatta gaggttttag tttttttgat
     3421 tttaaaaatt taaatgaatc gattcataac ttatggtact ttggaaatag taatttaaat
     3481 cttacagtaa tacaaatgta tataattgtt atattgacta ctatttttgc ttcttttata
     3541 tttgcacaaa taggcttaac actttcatct atatttaaat cggctgtaat tccatttata
     3601 ctaggtggat tgataatggc aattccatac tttagtgtag gttttatacc agataaagct
     3661 ataaaattta tgtcagtgac tccaaattgg attatgatga gccaacaaat ggttaagtat
     3721 aatgtaccaa gtattttgat agttttttct atagtaatct caattatatt aatgatagtg
     3781 ttaactaaaa taacatatga aaattttaca tcaagcaaaa ggttttaact aaaaataata
     3841 gtaattttat ttatatttta gtttaattaa aaataagata aatgaatttt agataaaata
     3901 tatgctaata tatatgtaaa ttattacagg aggttgttta tggaaaatcg tgttttaata
     3961 atagatgatg aagtagaaat attgaagctt ttagaaactg tcctaaaaaa agaaggcctt
     4021 aataatatat atactgcaaa aactaaaaaa gaaggattag aattatttaa aagtattaat
     4081 cctgatttga ttgtattgga tattatgtta ccagatggcg aaggttatga tatttgtaaa
     4141 gaaataagaa aaacctccaa ttctccaata atatttttat cagctaaaac cgaagaatta
     4201 gataagttac ttggactagc gattggagga gatgattatg ttacaaaacc ttttagccct
     4261 aaggaagtgg cttttagagt taaagcgcat ttgagaagat taagttattt tagtgatgct
     4321 caaaacgaaa gtaaaaatct aaataataat gaagaaaaaa ttatatcatt tggcccatat
     4381 atattaaatg aaagtagggc agaacttata aaagatggaa aatctatagg actgtttgca
     4441 aaggaactaa aaatcctatc tttatttgca cataatcaaa atcaaattat aagtaaagaa
     4501 aaactatggg ataaagtgtg gggagaagat tatgttggat ttgacaatac tataatggtt
     4561 catataagaa aaattaggga aaaattagag gataatcctt caaaacctga atatattctg
     4621 acaataaaag gtcttggata taaattagca gtaaaggaag attagaatat gaagtggaag
     4681 attactagaa attttatatt tacaattgtg tttgtagcta tatcagtagt aattataaat
     4741 atcatatcta tattgtatgt gatttcaact aatagctttt ttaaagttgt agattctgga
     4801 aataatcctg aagaatttgc acgttctttt gaaaaagatt tatatgaaaa agatggagaa
     4861 tttaaactat ctaagattgg agctgaaaaa ttagaaaaat caaattcctg gatacaggtt
     4921 ttaaatgatt taggagagga agtttatgga gtaaatgtgc caaaggatac tccaaaaaaa
     4981 tatacaccct ttcaaatggt gaataattac aagtatatag aaacaaagta tgttaatttt
     5041 gtactagaaa aatatttaaa caaaaaacat ttaaacataa tagtaggtat acctagtaga
     5101 gatatatcaa gaataatttt aacctattct caaaataaca ttaaaaaaac tttaaataaa
     5161 gttatcatta taacactagt aattgatagc gtggtagctt taggtgtagg atatttattt
     5221 agtagaaaac ttacaaaacc aatttcaagc gtactatgga gtattgagac tatggctaat
     5281 ggaaattata gtttatatct taaggacaga ggtatatatg aagaagtttt taaaaatata
     5341 aatatgttag ctgatacttt aagagtaaat gaagttgaga gaaaagaaaa tgaagagttg
     5401 agagaggaat ggctggcaaa tataacacat gatataaaga cacctctagc atctatacaa
     5461 gggtatgcag agataattaa tgacaaagat tatgagtttg aagaagatga aatacaagag
     5521 tatacagaaa ttatatataa taagtctaag tatataaaag atttagttga tgatttaaat
     5581 ttatctactc gattaaaaaa taatactata gttctggaca agaaaaaaat aaatttagtc
     5641 agtttagtca gagatataat aattgatatt ttaaatgata atagatataa aaataggaat
     5701 attgaatttg aaagtaatga agatttaatt gaagtatatg tagattcaat cttattcaga
     5761 agggctataa ccaatcttat atttaattca atagttcata atagcgaagg aactttgata
     5821 agtgtagaaa ttgtaaaaaa agataatata gaaattataa taaaagataa tggaattgga
     5881 ataagcaaaa gtgatttgaa acatattttt aaaaaatatt atagaggtac taatacaggt
     5941 gagatgcata aaggttcagg tcttggtatg gctatttcta aagaaataat agagattcat
     6001 aaaggtaaaa tttatgtaag tagtgaaatt ggaataggaa caaaaattat tatagagata
     6061 aaacaaaatt aggagatatg atatggattt ttttaaaaaa ggtataagtg ggtttactat
     6121 taaaatttta gcattaatat ttatgacatt tgaccatata gcagcattta tgccacaaac
     6181 aatgcaaata ccaatttggt ttcattgggt aggcagaata tcagcaccac tgtttatatt
     6241 catggctgtt gaaggatttt atcacactag taacagaaaa aaatatataa gtagattgta
     6301 tatttggtct gttattatgg ctataggaaa tcaaataatt aataatgtat tttcacatcc
     6361 agaaggagct ataattataa ataacatttt ttcaacatta tttttaatag cgatttattt
     6421 acaagcaata gagttcataa agaaatttag aaaagagaaa gaaattaaat attttattat
     6481 aggattattg atgataatca ttcctataat tttaggaata tttacagtag ctttactttt
     6541 taaagtcact aacagagtta ttgctttatt tatgattttg gtaccagtac catttttagt
     6601 agaaggtgga ccaatttgga ttatacttgg gattattttt tatttgtgta gaggtaaaaa
     6661 gttcagtttg agtatttgtt atgttttaat gtgtatattt atatttacaa caatgtcaaa
     6721 tggagattat agtttaaaaa attctatttt acaaaattac caatggatga tgattgcttc
     6781 tctaccttta atgttacttt acaatggaga aaaagggaag agtatgaagt atttatttta
     6841 tttatactat ccaatccatg tatatatatt gtatatctta ggaatatact taataaatgg
     6901 tttttgattg taagtgatat ttttaataca aaatgaacag tatgaggatt gttttaggtc
     6961 tattaaaatt gttatttaga tgagatttgt agaatattta aatttatgag cagaaattca
     7021 gttattgtaa tttcaataac attagaatat aatattataa tttatttaga aatatatgat
     7081 gttatacatg gtttggttat taatgtaata ataaaacaga ggtttgatat aaaattcaat
     7141 acctctgttt tagtgctttt tatcctacat ttatgcttat tttatttata aattagtgtt
     7201 ttgttttaat taatattagt acatttttta tttattttat aaaattagtc ataattgttt
     7261 cttcatattg tggttcttta attccagctt ttttacctgc tgatatacac ttaagaagcc
     7321 atgccatgtt ttctcctaga gttcgcatag tctgtaatcc ttcttcatcc ttcataacat
     7381 cctctggagt aaagccatgt acctggttcc aatactgtga tgatacaata ggcatattgc
     7441 tgattgaaaa atatttattt agttggtcaa atgttgcact tgcaccacca cgtctacatg
     7501 acacaactga agcacctaat tttgtagcca tgcgacttcc agctatgaaa aatagacggt
     7561 caagaaaaga agttaattga ccagttgcac tagaaaagta aacaggagaa ccaataataa
     7621 taccatcaat attatccaga tcttcaatca atttattaac tttatcattt cgaatacatt
     7681 ttccagtttc aaaacaggat gcgcaactaa tacatcctgg gattgtttct ttacctaaat
     7741 acagtatttc tgttttaata tcgtgtttac tcaatacttt agtaatctca tttagtgctg
     7801 tataagtaca tccatattgg tttgggctac cgtttatcaa taaaactttc attataaatt
     7861 tcctccaatg aattttattt aatagatttt ctaagagata ttatttttta taaaatagga
     7921 ttttcatgaa tattatcaat ttatatagaa atgtctaatc ttagaatcct atttaaaata
     7981 actttttttt tagtaaatac acctcctatt ataaaattga ctttcaatta ttcttacact
     8041 ataattttat tataaattat tctaaaaaca agtacgcaca tttttgttca atactaacca
     8101 aaaggagagt gtaatatatg agtatagact gtatatcaaa tacagattta agtgaaacag
     8161 gatttagtta tacactttca ctgattagtg gtaaatataa gatgataatt ctttactgtc
     8221 ttgtagaatt tgaagttgta agatataatg cattaaaacg ttatataaat actatctcct
     8281 ataaaacttt gagtttatca ttaaaagaat tagaagcaga taacttgatt attcgtactg
     8341 aatatcctca aatacctcct aaggtagaat atagtctatc agaaagggga aaatctctga
     8401 ttccaatttt agatgcaatg tgtgagtggg gagagaggaa tagaccttaa ttttgtatct
     8461 gtagatacca taaaaagact gtgagtaaaa ttgtttgaat aatctactca cagtctatat
     8521 ttaaattaat agttagtatt tttaatttat aaaaatacta aaaaatttat tatgaaattt
     8581 caccaccaat ttcttttaca tcttctttat atataataca agcttctata gctaattcta
     8641 agccttttac tatttcttct aaagacatga atggtgtatt ttttttatct attacttgtg
     8701 aagttgtata tgggatgtgt ataaatccac cccttatatt aggatatttc ttgtctatca
     8761 tataaagaat tccatacatc acatgattgc aaacaaatgt tcctgcagtg tttgaaacac
     8821 tagctggaat tttattttca ttcatatgtt ttaccatagc ttttacaggc aattttgaaa
     8881 aatatgcagg ttcaccatct tcttttataa tagtatctat aacctggtta ccctcattat
     8941 cttttattct aaaatcatct atatttatag caactctctc aggtgtaatg tcaaatctac
     9001 ctccagcttg tccaactgat attactatat ctggattgtg ctcttgaata gctttatcta
     9061 tagcttcaac agattttgtc ataactgttg gtatagttat ctttatgatt tctgcaccgt
     9121 ttatattatt attgaccctt tcaactgctt cttgagctgg gtttattggt tctccaccaa
     9181 atgggtcaaa tcctgttaac aaaattttca ttattttacc tcctaattat attaaaatcc
     9241 taaaaagtac attactaata tgtgggctat aattaatacc aaagcaactg gagcttgata
     9301 ttttataaca atataatcat ttttacattc tagcaaggct gctggaacta tattaaaatt
     9361 agcagccatt ggagtaagta gagttccaca atatcctgct gttaatgcta atgctccaat
     9421 tatagcagga tttccacctt gagacaatac aaaaggaata ccaattcctg ccgttatgac
     9481 tgaaaatgcg gcaaatgcat ttcccattat catggtaaat ataaccatac ctaatacata
     9541 agctataaca ccaaataatc tgctatcagc agggactaca ccagatatca tggttgaaat
     9601 aacttcaccg actccggctt gagtaaataa agctcccaat gcaactaaaa gttgtggtaa
     9661 catactagca ggtcccattt gttgaagtaa tcttgagcca tcttgaactg atgtagcagg
     9721 ttttgcctta gttattataa gggctgatat taatgcaatt attgaaccca cacctattgc
     9781 aaattgagaa gaattatcaa aattagaaag gctcatagct actactactg cagcaaatgc
     9841 taatattaat gatggtataa atattttatt tttaagtttg tctgcttgtt cttttccaaa
     9901 attttcatct ggttcttcat actttgcaaa tacaacttgt ttagaaagtg ttaataaact
     9961 agataatatt aatattattc ctattatatt ggctggaatc aatctaccaa atatgaatgg
    10021 cagtgatata agtatccaaa ataatgatgt accatatttc ttattgttat ttatggtagt
    10081 aaaagactta tatgctataa caatcattaa aaatcccatt agtgcgtaaa agatttctaa
    10141 tgatatgttt ataaaatttt gcatttttat tcctcctaaa taaaactatt ttttatgact
    10201 tttgtttaat tttttatcat ataaggtaaa ctggattgta gccactacaa gtgctattac
    10261 tgccataata gtactagcct ttacgatatt aagtccagtt acattgtatc caaattgagt
    10321 cagagtagat gctataagta atactccact actacctgca aataagtttt gaccataaaa
    10381 atttccatag ttttctgatg cagcagataa tgcctttatg gcttcttcat ccgattcttt
    10441 tagttcatca ctattactta aaccagcagc ttgtgccata ggattaacaa gtggtcttac
    10501 aaattgagga tgtccactca ttcttattga tagagcacca gctatttgtc tagctatcat
    10561 gtatatagta agtacttttc ctgttgtaag tctttttaat ttttctatta aagaaacagc
    10621 tctttgtttt aaaccatatc tttctaatac accgattact ggcaatgtta atatgaataa
    10681 tgatacacct ctgtttgaga caaaagaatc tcctaaaatt gtaaaaattt gattaaaatc
    10741 taatcctgca acaattcctg ttgccactcc tgctaataat acagtaaata atgtgtcaat
    10801 tttaagtata aatccaatta caactatcaa tataccgatt agttttatca taaattgttc
    10861 tccttccatt tctatatgtt ttaatttaaa tttatttaat ggataaagtt aaactctttt
    10921 tatagtattt gcgttaatag gactattatt ataaaattta ataaaaaata gggaagatgt
    10981 tttaaagtat caaagtaaat aatggttgtg tataggaatt tgaataacaa agattatatt
    11041 ttaagctaat atgaattgat tttgtaagtc tatagtttaa gtatatgtca atatttgaaa
    11101 taggttttaa attagatatt atattataaa aagagaatgt gccaaacata gagacaagtg
    11161 tatttttcac ttttgaaatg ataaaaatat atttgatttc atacaaaaag agagtgtcta
    11221 atgaattttt tagttcatta gacactctct ttttgttatg attaataaaa catatttgtt
    11281 atgattaata aagcatatat taagtgctag tttcattaga tttcactaag aaaaataaaa
    11341 ttttgataaa gtttaaagac tattttgagc aatattactt ataaataaaa gaatttatca
    11401 tagaaataat tagttttatt ttagctatta agatttatta aaaaattatc tatattatcc
    11461 tgtgatattc taaaactgtc ataattacct tttgaaacag ccttcataat aagtttatct
    11521 aaaaatttca ttttttctaa tcgagcttca ctaccaaaaa ttccaatagc atttgcactt
    11581 tctaataagg atgatggaaa atttgatttt aaatatttat ctgcttgttc agaaaagcca
    11641 cagcaaagga aaatgccaac ttgttttttg tttaataact ctacattatc attacatagc
    11701 acttgtattt tttttgaaac tgaaccaaca tatatagaac ttccaataat aattttatca
    11761 aattttgata actcaatttt attattatta ttaatatcaa caatagtgac attatctgat
    11821 agtttatttt ttagtatatt tgcacagtct tttgtacaac catatttact tgaatatata
    11881 ataatagtat tcataattat tctccctttc ttaaagcatt ttctacagct tttcgtatag
    11941 tattactgct ataagttgca gaagttatag catccacatc taaagactgt tgtttaataa
    12001 tacttgttgt aattttttca gcaggtttac ctaaaagatg gtcgtgtttt aagatattaa
    12061 tattttggat tttaccatta ttaacttcaa cagacacagt agcttttacc aagttattat
    12121 cagcacttcc agtataaatg ccatttttaa cattattaat atctatatct tttactacca
    12181 agttttctgg ctttaagttg cttacaatta caataataat gcatataaat acaaagaata
    12241 gagcaataga tatttttaca tattttttct ttttattagt agccttgttg cgaattttca
    12301 ttgtaaagtc ctcccactaa aatatctaag aaattttcta taagttgaga aaaattatgt
    12361 aaagaatata gtttattttc aacaacacat aaaacgaatc ctaacaatgc acttataagc
    12421 atccatgagc ttttatctat attttttttg aatattcctt gttcaattcc aatggaaagg
    12481 aatttatcaa gcatttttat accattattg ctaggcgtat tgtttgtatt ttcagatgca
    12541 aatataatat tcattctact atacatgata gattttgcca tctctggttc actagaaaga
    12601 gtttttataa agctagtcat aatttctatg atttgtttat ctattggtag tgatgagcaa
    12661 ttattcataa tgtcaatggc attactttct actgtgttat aaagtttatt ggtcatatcg
    12721 ctgataatct ctgctttgtc tttgtagtaa agataaattg tagttggaga atattctatt
    12781 tttgtagcaa tttttcttat tgataaattt tcatatccat gttggtttat aatttcgatg
    12841 ctagcatcca taatcttttt cttcatttct tctttttcat ttttacgtct ttctttgata
    12901 ctcatataat cacctctttg cttaacggtg ttaagttaat ttacactgtt attgtataat
    12961 ttaattttaa tactgtcaat aaattattaa ataatataag ttaatatatt tttatggata
    13021 ataaattaat gttattaatt gtaatattta agatattatt gtataataat aatcggttta
    13081 aatgcgccac atcttattaa agttggttca taattctaaa taaactttaa taagatacat
    13141 taaaatataa taaattcttt tatgctataa aatttatttt atagctatta aatcagatgt
    13201 ttaaaaattt tttaacagtc tatagttttt aagagtctat agtaagtagc ctaaaaatat
    13261 gattttacat ctgtacttgt tcgagaactc caagtataaa aaactaagga attatatagt
    13321 ggcagtatat aattaatacc cttagacaca cctttttgaa agtggaaaaa agatgtgtag
    13381 ttctcctcga ccacaaatca aggaggataa aaaatggaaa agagaaaagt aataattgat
    13441 tgtgacccag gaattgatga ttctttggca attcttctgg ctttaaactc accagagcta
    13501 gaagtaattg gaattaccac atgttgtgga aatgttccag caaatatagg tgcagaaaat
    13561 gcactaaaaa cacttcaaat gtgttcttca ctaaatattc cagtatatat aggagaagaa
    13621 gcaccactaa aaagaaaact tgtaacagct caagatacac atggagaaga tggtattgga
    13681 gaaaactttt atcaaaaggt tgtaggagct aaagcaaaaa atggagcagt ggattttata
    13741 ataaatactt tatataatca tgaaaaagta tcaataatag cacttgcacc acttacaaat
    13801 atagctaaag cacttattaa agataagaaa gcatttgaaa atctcgatga gtttgtatct
    13861 atgggaggag catttaggat tcatggaaat tgctctccag tagcagagtt taattattgg
    13921 gtagacccac atggagcaga ttatgtttac aagaatttat ctaaaaaaat ccacatggta
    13981 ggtttagatg taactagaaa aattgtactt actcctaata ttattgagtt tataaataga
    14041 cttgataaga agatggcaaa gtatataact gaaataacta gattttatat tgatttccat
    14101 tgggaacagg agggaataat tggctgtgtg ataaatgacc ctctagcagt agcgtacttt
    14161 atagatagaa gtatatgtaa aggatttgaa tcatatgtag aagttgtaga agatggaata
    14221 gctatgggtc agtctatagt ggattctttc aatttctata aaaaaaatcc taatgcaatt
    14281 gttctaaatg aagttgatga gaagaaattt atgtacatgt ttttaaagag gctttttaaa
    14341 ggttatgaag acattataga ctctgtggaa ggagtgatat agtgtgaaaa gaaaaatatg
    14401 tgtaaaaact attacactta tagcttttgg tatttctata aatataatag gcgcttttat
    14461 agctatggga ttaagattac ctgtatactt agattcaata ggaactataa tgatagcttc
    14521 acttttagga cctaaatacg ctgttgttac aggtgtgttt ggaagtttaa taagtggaat
    14581 tacgtttgat gtgtattctc tctattttgc accagttcaa atatcaaccg gattacttgc
    14641 tggaatagca tttaaaaaga attttttaag gggtttaaaa actccactag gagtactttt
    14701 atttgccatt ccaacatcta taataagttc aataatttca gcatttttat ttggaggtat
    14761 gacctcttca ggttcatcat atatagtgca aatcttgaaa gtgttaggac tgggggatgt
    14821 ttttagtgtg tttgtaaccc aagtatttac tgattatgga gataagctgt tagcagttgt
    14881 tttagtgaat ttaggattaa atgcagttcc aaaaacttta aaggtatcat tgactggagg
    14941 aaaatagata gaaaatggat agatatagtg agataacaaa taaaaatcaa agagaaattg
    15001 ttctgcttaa aggatttcct tgtatatggg gaaagtgttc tttttgtgat tatatagatg
    15061 ataattctaa tttagaagaa gagatgaata aattaaatct aaaggtttta aaaaacgtaa
    15121 ctgggaaata tggagttctt gaagtcataa attctggaag ctgttttgaa ttacctaagg
    15181 atactttaga aaaaataaag tgtattataa aagagaaaaa tataaaaaaa ttatttttag
    15241 aaagtcattg gtcttacaaa aataggctta aggaaatgag agagtatttt gaaattcctg
    15301 tggtatttaa aattggagtt gaaacctttg acaatgattt tagaaataat attttaaata
    15361 aaaatgcaaa ttttaagact ccacaagatg taaaagaata ttttgattca ccttgtatta
    15421 tggttggaat aaaaggacaa acaaaagaga tgatagataa agatatagag attatcctaa
    15481 atacttttga aaaagcgaca gtgaatgttt ttataaataa ttcttctagt ataaaaagag
    15541 atgaagagtt agtgaaatgg tttgttagta agtataaatt cttggatgaa aatccaaata
    15601 tagaagtttt atacaataat acagattttg gtgtaggaga ttagcattaa tttagtttaa
    15661 atttaaaatt gaaaagtttc ttatgttttt gaaaaagctt ctaatagtta gaagcttttt
    15721 ttgtagagtt ttatgttaca ataagaaaaa aggaattaag gagcaattaa atgatgtttg
    15781 atagggtaaa atggaataaa ttggattata atgaactttt agaatatatg atgtctatac
    15841 aagatataaa atatagagat tttaataaaa agcttatacc tggaacagaa aatataatag
    15901 gtattagagt tcctaattta agaaagttat caaaagaaat aagccaaggg aattggaagg
    15961 aatttttaga agtagcagag gatacatact atgaagaagt taggctacaa ggtatggtaa
    16021 ttggcaatat aaatagtaat tttgaagaaa ctttatacta tgtaaaaaga tttataccta
    16081 aaatcgataa ttggtcagtt tgcgatggat tttgttctga tttaaagtct atgaaaaaat
    16141 ataaagaaaa tatgtatgat atacttaaaa aatatgttta ttcaaagaat ccatgggaaa
    16201 ttagatttgc attagttatg tttttaatat attatgttga tgataaacat attaaagaaa
    16261 tatttgaata ctgtaataat atacaaagtg aagaatatta tgttaaaatg ggtatggcat
    16321 ggttgctatc aatttgtttt attaaatgtg aagaggaaac ttttctctat ataaaaaata
    16381 ataatttaga tgatttcact tataataaaa tgctacaaaa aataattgaa tcaaatagag
    16441 tagatttaga aaagaagaat ataataagaa gtatgaaaag aaagacaaga agatgttgac
    16501 ggaggaatat taatgaataa caatgaagac agaattgaca aatttttaga acttcaaagc
    16561 aaaggattta aatttgcaga gatagctcaa aatctaaaga ttagtcaaag tactttaaga
    16621 acttttttaa ataaaaaagg atataagtca gaaaaaggta aatacatatt taaagacgaa
    16681 ttaaattata ataaaagttt ggataataga aacttggaag aagagaaagc taaggagtat
    16741 gaaaaaagta aaaagaatac tataagtaat agaaaaaaag taagcaccaa aaaaaagatt
    16801 tctaatgaaa aggctttaag taaaagtgtt gaacaaattg agtttaatga tacaggttta
    16861 aaaaatgcaa agccaaaaca aaatattaag cctaagaaag atagaaaaat aaatataact
    16921 caagaagatt tagataagct ttgtgaagta tatgattggt atttagaagt aaaagattac
    16981 aatataaagc ctaaaaaagt atctaataaa aaagatgtac atatagatga tgaacacata
    17041 gatgaattaa aaacaacaag aatacgtata gataaagaaa tatggaatga ttttgaaaga
    17101 ttatgtagta attcgaattt tgaaaaacat caaatactta cacaggcatt gaaagaattt
    17161 atgaaaaagt ataaaaatct actataaaat actactatat gaggtgctta atatgaataa
    17221 aatagtaaaa aaatcaattt ctctaatgat tatattaaca atatttattt ttatgttgac
    17281 agcatgtgaa aaagatgaac agcctgattc agttgatatt caaacagaag ataaaaatga
    17341 gataaaaata gatgagggaa atgcaaaagt attgaatata ggaaaatcag aaattataaa
    17401 tatagatgaa ggtgataaag tagatacatc aacaaaggta gaaaataatt caacatttaa
    17461 tatatccaat gttgaattga tatataatga atatgatgag aataaaaaaa ttatatcttc
    17521 ggatagtaag gctttgttgg acatgacttt aatgcctggg aaagttgctt acatagaatg
    17581 tgggcataaa acttttgtaa agggtgtaga agtttatgca tatgaatatg aggcagaggg
    17641 taagattgtg tatgttaatt taaaagaaaa tactattaat ataagaaata ataatattaa
    17701 gctagaaaat agtagtcagt atgaggtgct atctacatca gaacttaaaa aagtaaatga
    17761 atcaaatgag ggaattacgt atcaagtaaa agtaaaaaat tcatcatcaa aagatttagg
    17821 aaatattatt cttaagacag cagaagttaa tgaaaatgga gaatatttaa cagtaaatcg
    17881 tgtgccatca tataagattt taaagccttc agaagagaca gatatagata tattgtgttc
    17941 aacaaaggca aaaagtgttg aaatagtggg atatacgtat gatgatataa aagaaaaagc
    18001 caatgtggat attgacttaa aatctcataa agttaagata gacaaataaa ggtaggggat
    18061 acttatgaag gttttaatag ttgaagataa taagatactt ttagaaagtg tagtagaaga
    18121 acttagcaag cattttgaaa ctgaaaagtg tgaagatgga gaagaagctt tatacttagt
    18181 aaatcaaaat atatatgatt tagtcatttt agacttaatg cttcctaata taaatggatt
    18241 tgatatccta aagaaaatga gagttaataa tatagataca cctgtactta tattgacagc
    18301 aaaagaaaca ttagatgaca aagtagaagc atttactata ggagctaatg attatttgac
    18361 aaaacctttt tatatggaag agttagtagc tagggtatac gctatattaa ggactaatgg
    18421 aaagataaaa gaaagaaacg gattagaatt taaatcttta tatttagata cactagaaaa
    18481 aagagtgtat attgaaaaag aagaaataaa acttcaaaac aaacagttta acttgcttga
    18541 gtattttgta ttaaataaag gttcaatttt attaaaagag cagatttatg atagaatatg
    18601 gggaattgat tcagatgcga ctattgaaat agtggaagta tatgtaagta atctaagaaa
    18661 aaaactaagt aaatatggat atgataaata tattaaaact aaacgtaagg taggatatat
    18721 attcgatgat aaataagaat gtatttacca gtactaaaaa tcatttaata aaaatgtata
    18781 ttattgtagt aggtagtttt ttaataatct tttctatatt tatatactca tattttaggg
    18841 gacttacata tagtggaatt gatagtgaga taaatgatga acttgaatat atagtctctc
    18901 aatttaaaag aacttcattt ttgaacccaa taagactgaa agatcctaaa gatatggtgt
    18961 atgtgtatga agatggaagg ataagttact atactcaaaa tgaatatttt gatgagttac
    19021 ttccagatag aagactagat aaaaaaaatt cgttttttaa atacacagaa aatggatata
    19081 cttttagaga attaaatgta gatgtaggta gataccaaat acagataatt agaaatatag
    19141 attctgagat gaattcttta agacagctta catctgttct tataattgga atattaattt
    19201 ctgtaataat tacttacttt gtggctgtat atctcactag aaaagcttta attccaatag
    19261 aaacagcatg gaaaaatcaa gctaagttta tacaagatgc ttctcatgaa ttaagaacac
    19321 caataacaat agtttcatca aaattagaaa gtatgttaaa atccccagaa agtacagtaa
    19381 atgatgaagt tgaaacaata gctactgcaa tgaaggaaac tagaagactt aaaaaaatga
    19441 taactgattt attgtctctt actaaagagg actctattgt taaagttaat ttagaagaaa
    19501 tagatttaga aaagttattg gaagaaatat cagaagacta tattgacatt gctgagtttc
    19561 aggaaaaaag attcgtgttt aattctaaac ttaagaataa agttataata acagataaaa
    19621 ataaattaag acagcttata ttaattttca ttgataatgc ctttaagtat acaaaattgg
    19681 gtgatgagat agcattagaa ttgaaagaag atatagagga tgaggtaact ttacttataa
    19741 gtgacactgg tataggcata aaaaaagaag agatacctct tatatttgat agatttttta
    19801 gaagtgaaaa tgtaagaaat aaagatttag aaggttctgg aataggactt tcaatagctc
    19861 gcatgattag tttaaactta tctattgata taaatgtaac ttctgatgta gatattggaa
    19921 ctacatttga attgtcaata cccaaaaagt taaaataata aaaatataaa aaattgtttt
    19981 tagaaatgaa gaatgggtat actaattagt ataaaatata aaaagacctt ataaaagtaa
    20041 atttatattt ataaatttca tagtataatt atatagggat aataaagttt aataggagga
    20101 tttaaaaatg gcaaaagtta taaatacatc tgaatttaga agtagtgttg aaggtagtaa
    20161 gggagtagtt gtagttgatt tctttgcaac ttggtgtgga ccttgtaaca tgttgggacc
    20221 tgtatttgca gaattaggtg aagagatgaa ggataaagct agatttgtaa aagttgatat
    20281 agatgagagc ttagaaatag ctcaacaatt caatgtatct acagtaccaa ctatgattat
    20341 atttaaagat ggaaaaccag tagaaacttt aattggattc atgccaaaga acaaaattga
    20401 aatgcaagta aaatcatatt tataaaaaat gggtgagtat tatgagatat gatatagcta
    20461 taatcggcag tggtccagct ggattgtctg ctgctataaa tgcaaaaata agaaataaaa
    20521 caattatcat gtttggtaat gataatttaa gtaataagct tgttaaagct ccttcaatag
    20581 ataattattt aggtttttat gatataagtg gtgatgaatt aaaagacaag tttaaatcac
    20641 atatagatag tatggatatt tcaattgaaa ataaaagaat aaataatatt tatgctatgg
    20701 gagaatactt tacaataatg tctggaaatg atatgtatga agctactact gtaatccttg
    20761 caactggggt agagtatact agaccaatca agggtgaaga agaatttcta ggaagaggtg
    20821 tgggctactg tgctacatgt gatgcaccac tttatagaaa taaaaaggta gcagttatag
    20881 gatataatga agaatctaaa gaagaagcaa attttttaag tgaactcact tcaaagactt
    20941 attttatacc tatgtacaaa aaagataatc ttatgagaag ttcagataac ctagatgatt
    21001 ctattgaagt tatacatgac agaccagtac agatagatgg agataaactt gtaaacaaag
    21061 tatcttttaa agaaaaccac attgaagttg atggagtatt cgttataaaa gatagtacag
    21121 ctccaagtgc attggttcct ggaatagaga ttgatggcat tcatattaaa gttgacaata
    21181 atatgaagac tagtatagat ggatgctttg ctgctggaga ttgtgttgga aaaccatatt
    21241 cttatataaa agcagctggt caagggcaaa tagcagcttt aaatgctgtt tactatttag
    21301 ataaattaaa gagggcttaa tatttatatt gattaacttt ttaaagatat ttataaaaaa
    21361 ctgtcttgaa ataattttat tatttcaaga cagtttttta tttttaagtt attaataaaa
    21421 gtattttaaa atctatatgt aattactttt attaataaaa ctcaaagtta tattagtaaa
    21481 aattggaatt atttataata tactccaaaa tttaaaaata atggttgaaa aatctaatta
    21541 agagtactat aatttaatta agtaattact taatcaaaac gaggtactta tggaaaactt
    21601 ggttaaaata tttaaagcat tgagtgatga aactagactt aacatactta tattagtatc
    21661 caagagaaat atatgtcaaa aggggatttc taaatatcta gggatttcag attctgctgt
    21721 ttcacaacat ataaaaatat taaaagatgt tgggataata acaggatata aagaaggata
    21781 ctatgtttta tatcatatta ataaagaatc atttaatata tgtgtagatt ttataaattc
    21841 tatgttaagt aattctagtg aaagctttat agatgtattt gatgtaaata caatacatct
    21901 aggatgcagt aaagaatgta aatctataaa aaaatgttgt aagagaaggg agaaataata
    21961 atgaaagtat gtataccagt agaggagaat aaaggattgg atagtaaacc atatggacat
    22021 tttggttctg ctccaatttt tgttgtgtgt gatttagaaa gtggagaagt taaatcttta
    22081 gataatggag atttagatca tgaacatgga aaatgtcaac cattaaaagc attgtcaggg
    22141 acagctgtag atgcagtagt tgttggagga ataggacaag gagctataat taaattaaat
    22201 ggaatgggaa taaaagttta cagagcagaa ggtgatacta taagtgctaa tttagactta
    22261 cttaaaaatg gaaaattagt agaatttcca tcagaccata cttgctcaca tgacggatgt
    22321 ggacatcatt aaaaaaaaac agctgatgaa atatatactt catcagctat tttttctttt
    22381 aataaatacg attttattct tttaaaacca aaatttagat ttttatattt tttgtagtat
    22441 ccttaataat atttcaagtt tacaagttta ctacttttag attttttttg tatgtttttc
    22501 tatatagtca atatcattta atatgtcatt gagttcttta ttaagtgttt ttaaatcatc
    22561 accatctaca ttgtagttta aaaatagttc ctctacatta tcaatgatag aattgacttt
    22621 tctagtaact tcaacaaatg tcttaaagtt actactattt ttagcattta gaaatttttt
    22681 taaatccttt gatataaatg atactatttc atattcatca ttaaatagac ctctaccaat
    22741 aggatatggt tcaattctct gtaaaaaata ttggtcttta gcattaatat tataagtata
    22801 agatatttcc caaccgtctc ctaaatcaaa cttgataaaa tataatgtac tacttacttt
    22861 tgatattctt gtggcaccaa gctgtcttaa aagaacttca atcgaatcac cttgaacagt
    22921 attaatattc atatatacac atccccttta gtattattat actatatttt ttaaaatttt
    22981 ataattaaat aaacagtaga tataataata gatataatca taagtggaaa acctattttg
    23041 aaatactcct taaaagagat aggatgaccg tgtttattac ctatacctgc tagtacaaca
    23101 ttagcagatg ctcctattag tgttccattt cctccaagac aagctccaag agatgttgcc
    23161 caccatagtg gcattacatc aataccttca gcttgcatag tcaaaataag aggaattagt
    23221 gttgcaacaa atggaatatt atctaagaaa gaagagacta tagctgacaa ccataatatc
    23281 aacaacattg taaatacaag atgtccttct gtaagtccaa tcaatgcttg agccaatttg
    23341 tttattatcc caacttctac taatccacca actactacaa ataatcccat aaagaataaa
    23401 attgtagacc attcaatacc tgccataatt tcatctacat cttgttttcc tattaaaagc
    23461 attatagatg ctcctgtcag tgctacaaca gaagaatcta tgtggattgt actgtgaaac
    23521 ataaaaccaa aaagtatgaa tgctattaat ataaggcttt ttataagtag aggtttatct
    23581 ttaacagatt ttttttcatc tagttttaat attgcatttt tagctctttc attcacaaca
    23641 agttcttttc cataaataaa tctaaagcat attatagtta tagcaagtat tactataaca
    23701 gcaggaccta aatttattac aaaatccata aaactaagat tggcagcact accaatcata
    23761 atatttggag ggtctcctat aagagtagct gttcctccta tatttgaagc taaaatctgt
    23821 gttattaaaa atggaactgg attaagtcct aatatttgtg taataactat agtcattggt
    23881 ccaataagta agacggttgt aacattatct aatacagctg ataaaatagc tgttataata
    23941 gcaaagcaaa tcattatctt ccatgggtca cccttagctt tctttgcagt ccagatagct
    24001 atatattcaa ataaccccga gtttttgaca acagctacaa atagcatcat accaactaat
    24061 acaccaatag tattgaaatc tatatggctt aatccttcat caagtgtaag tatattgaat
    24121 attatcatta atagtgcacc accaacagct gctacggatc tgtttacctt ttctgtaata
    24181 atagctgcca taactattaa aaatatacat atagctatta tttgttgaaa ttccataata
    24241 taagtacctc catttgtatt attttgtgcc taatgctagt actatatata gtattacttt
    24301 tttattgttt tttcaatgga tgtatgaaag tatattattt aacaaagttt ttgaaaaatt
    24361 gacagaattt aaagaaaatt tttgttattt aaataaattt taaaattatt ccattgataa
    24421 taatattaaa cgacaaacga aaaaatatac cctttaaact aga
//
LOCUS       DAEPID010000058        24126 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.058, whole genome shotgun sequence.
ACCESSION   DAEPID010000058 DAEPID010000000
VERSION     DAEPID010000058.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 24126)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 24126)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..24126
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.058"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            384..896
                     /locus_tag="KR257_002610"
     CDS             384..896
                     /locus_tag="KR257_002610"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436941.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0031292.1"
                     /translation="MKVKKFKSGIVMALTVMAIGASLTNVSAMELNKSKEFETKYNEM
                     KMDFQEEYGKEDKFNITLDDEFTKEEVNGAKGIIKTTNKMNNEVVVLNYFDEMKSGIE
                     FELKPKAEKNAILRDEFQQGYGKEDKFKVVLDDEFTKEEVNGAKGIIKTTDKETGEVI
                     VYNYFDELEK"
     gene            complement(1349..2446)
                     /locus_tag="KR257_002611"
     CDS             complement(1349..2446)
                     /locus_tag="KR257_002611"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418382.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alanine--glyoxylate aminotransferase family
                     protein"
                     /protein_id="HBH0031293.1"
                     /translation="MKKTYLFSPGPVMVTDKVRNSLLHYDICHRGNEFMDLFKDTQQK
                     INKLYNATSNYYSLIVSGSGTSVNECVLSSIFDKEDAVLLVSNGVFGERLEEILSTYN
                     VKTYKPNFEWAEYPDLDILEKYIIENSDIKVIAMVFHETSSGMINPVPELGKLAKKYN
                     KIFFVDAISASAGEYIDVEEFNIDIITGVGGKALGAFPGSAYLCAKESILQNIKENQC
                     KNVYLNLYKHYKVAKSSSQTPNTPNVTLIFALNEALTEFLEDDSKIERYKECSAILRN
                     GMEELGLTFLLPDKYMSNTVTSVFLPKEINVNEFILGLERESGYVVYPGKGKFLDANI
                     FQVANMGEIYPEDCYKFLDILKSKLEIKKVI"
     gene            2739..4265
                     /gene="glpK"
                     /locus_tag="KR257_002612"
     CDS             2739..4265
                     /gene="glpK"
                     /locus_tag="KR257_002612"
                     /EC_number="2.7.1.30"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003432232.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycerol kinase GlpK"
                     /protein_id="HBH0031294.1"
                     /translation="MKYVLAIDQGTTGTRAVLINEKSEFVFSDYMEHTQIYPQSGYVE
                     HDPIEIWNNTKTVSNNVLQQAFENGINESDIKGIGIDNQGETVMLWDKNTGKPLYNAI
                     VWQCRRTYDYVENLKNIPGLENKIIDKTGLIIDPYFSGTKIKWVIDNVKGVKEKIKNG
                     EVLAGTLDSWLIWKMTGGKSFLTDVSTAARTMLFNIRDMDWDRELLDIIGVPRSILAD
                     IMPTSGDFGTTDKEAFCGVSIKITASMVDQPAALFGNGCFEPGMVKNTYGTGCFLYMN
                     IGEELNIAGNGILTTVAWKIGDKVTYAYDGGVYIAGAAIQWLRDGIGVIKNYSETDDM
                     ANSISSTGGVYFVPAFAGIAAPYWDQYARGTMVGITGSTKKEHIVRATLESVALQVKD
                     VVDSMNLASGKKIKMLRVDGGITKNNFTMQFQSDILGIPIEIAENPETTVLGVGYMAG
                     LSCGVWNSIDEIRSEFTISKKYIPNMTTQKREEILLGWNQAVKRAMNWENDTKKVCAN
                     "
     gene            4306..5421
                     /locus_tag="KR257_002613"
     CDS             4306..5421
                     /locus_tag="KR257_002613"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860941.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ethanolamine utilization protein EutH"
                     /protein_id="HBH0031295.1"
                     /translation="MPFDKIILYIMAVGVLLGALDRIIGNKFGLGEQFEEGFNSMGPL
                     ALGMVGIVCLAPVISDVLGPIIIPIFNLCGADPSMFATILANDMGGYPLAMELAHNKE
                     AGMLAGLVVSSMLGCTLVFSIPVGLGLIEYEDRPFFAKGLLIGLITIPFGGIIGGLIA
                     GFNLSMVIINMIPVIILAVILAVGLKFNSTLMINGSLVFGKFISILITIGLGAAAFQE
                     ITGIVLIKGMTPIREGIQVIGSIAIVLLGTFPILHLLVKVLNKPLTIVGGKLGMDATS
                     AAGLVFTLANSIPVYKMMKDMSPKGKVVNTAWLVCATAALGDHLGFTAGVVPEMITPV
                     VIGKLVGGVLAIALAILMTKDLTLEEEQSIKMKKDAV"
     gene            complement(5702..6466)
                     /locus_tag="KR257_002614"
     CDS             complement(5702..6466)
                     /locus_tag="KR257_002614"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418385.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DeoR/GlpR transcriptional regulator"
                     /protein_id="HBH0031296.1"
                     /translation="MLPQERYEKILSILKSDNIIKINDIVQMFDISIETARRDLAHME
                     SIGLLKRVYGGAIPVIASSVELNYVKRKKINSNDKKQIAIKCSEFINTNDTIFMDTGT
                     TVLEVSKNLKDKKNLTVITNSILVANELMNTNIKVYVLGGYLRETEGSFSGPLTLSAI
                     EQFNVDKAILGAGGITLENGISDYHLEEALVRKKMIERSRKSIVVVEPPKFGINSFAS
                     VAPIEHIDTIITSASIDHNIIIEFSQKGIPLVIADN"
     gene            6725..6815
                     /locus_tag="KR257_002615"
     tRNA            6725..6815
                     /locus_tag="KR257_002615"
                     /product="tRNA-Ser"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:6759..6761,aa:Ser,seq:gct)
     gene            6903..7691
                     /locus_tag="KR257_002616"
     CDS             6903..7691
                     /locus_tag="KR257_002616"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888553.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flagellar motor protein"
                     /protein_id="HBH0031297.1"
                     /translation="MTTLIFFIVGIASLVVAFVIDGGHVGALFVFSSALVVFGGTIGA
                     VGASTPFPVFKKSIKIMLLTFKNKKPNNIENIIYFKEIATKARKEGLLSIDKEISEND
                     ELDPFIRKGLELMVDGVDAVTIRNILESQIQITSKRHKEGIAIFDSAGGYAPTLGIIG
                     TVMGLVHILGNLSSNPDALGPQISVAFLATLYGVGSANLIWLPIASKLKAINQQEVSE
                     RLLVIEAILSILEGDNSNLMTEKLKIFLNSKELIELEEIGGRAE"
     gene            7712..8452
                     /locus_tag="KR257_002617"
     CDS             7712..8452
                     /locus_tag="KR257_002617"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902133.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="OmpA family protein"
                     /protein_id="HBH0031298.1"
                     /translation="MLYDEDEKEENNERWLLTYSDLITLLMIFFVIMYSMSNVDAEKY
                     KQLSQSLNSAFGGSSGVIEGGNSKIEPVVEPGSNDLDTLQNAKFKKIGEEIQKYLNEN
                     GMANSVSLRVQDRGLVISLKDTILFDTGKAIVKDNSRDKIIQIGKMLNEMNSYMRVEG
                     HTDNMSIKNSEFKSNWDLSVMRATNVVQLLIDNAGIAPDKLSAVGYGEFRPIAENSSE
                     EGRSKNRRVDIVLVDSKYDNVENVSKDK"
     gene            8628..9002
                     /locus_tag="KR257_002618"
     CDS             8628..9002
                     /locus_tag="KR257_002618"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860944.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0031299.1"
                     /translation="MGNKNKNTKYKDKTRERYNKKVENLNKEKLNKINKQSKKVDKID
                     DIINKSSIVLCVLLVVFSLLYLFKLVQLNIIMILLVITVAIQQGLVSFGAFRNKNYVK
                     ALFSIFVIVCFLIAFKYVVNPV"
     gene            9094..10554
                     /locus_tag="KR257_002619"
     CDS             9094..10554
                     /locus_tag="KR257_002619"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888556.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="extracellular solute-binding protein"
                     /protein_id="HBH0031300.1"
                     /translation="MNRCKFAKLIITSMIVLLLTGCSLKKEDNYKLDPENPTSIQIWH
                     YYNGQQKMAFDKLVKEFNDTVGAEKGIIVEAFSQGNVVDLSEKVLDSANKKVGSEDVP
                     NIFAAYSDTAYEMDKLGLLVDMDKYISKEELNEYIDEYVEEGRINSKDEFKLFPIAKS
                     TEILMLNKTDWDKFAKATNSNINDIKTIEGLVETSKKYYEWTDSLTKEPNDGKAFFGR
                     DALANYIIIGSKQLGVEIFSVKDGKVTLNIDEKVMKKLWDNFYVPYINGYFASYGKFR
                     SDDAKTGDILALVGSSSGAAYFPDRVMLNDNESYNIETSVFQAPRFKGEGKYAVQQGA
                     GMAVTKSTKEEEYASVEFLKWFTDKEPNIKFSIASGYLPVKKKTNDLDVIKEVMKKDN
                     LSLSDKVEGSIASSIEQINSCNLYTNKAFDGGTKARQILEYSMLDKAKEDSNKINELV
                     KSGTSKKDAVAQFNNDKNFKTWFESFKAELENAIKK"
     gene            10607..13636
                     /locus_tag="KR257_002620"
     CDS             10607..13636
                     /locus_tag="KR257_002620"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418390.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="EAL domain-containing protein"
                     /protein_id="HBH0031301.1"
                     /translation="MENNLRKNNSIMKKMIFPLIIVMLIQTSLFCATILWGGTIKKLN
                     DNSFDILNERVINRKNYIQNEMLQRWSNTSETEATINSSVKKVLNEKNALIEDVGNNE
                     EINKDIIKSISNDLIYLLRKNSVTGAFIILSDKNINDKSIDSKGEISRTGLYIRDLDP
                     KFNPNDNSDLLIERGSSDIARSFGISMDSYWEPKFSFKSENEQDGDDFFYKPFRAAID
                     NPNVSSSNLGYWGSKFLLTNAGDRLMTYTVPLIYEDGTVYGVLGIDLSVNYLRELLPY
                     SEINGNKKGNYILGVDRNNDMAFENVISNGYSLKEKFWDGLHSNLEQKESYKNIYKIK
                     NKDNECGNGNIYASVQYLDLYNSNTPFENERWALLGIIEEKSLLSFSKRVEKLVIISI
                     AISLLIGLIGIYIASRLFTKPIVLLANKVRNSNPSKPVNLDKINISEIDELSSAIELL
                     SANVADSSSKLSQIIEMVDMPIGAFELYKNAENVFCTKEFFSVFTTEIKFEEYGYMEK
                     NKFLKKLRGLDKYLQESYETENTYIYKFESKDKKLKWIRMNIFEDELKVLGVVVDVTK
                     EFIEKRKIEYERDFDILTNLLNRRAFHSQIQEKFKNKDELKIAAFIMWDLDNLKYIND
                     TYGHDAGDEYIRCAADILKKFISWNGIVSRLSGDEFYVFIYGYESKDSIRDIINSVKK
                     QMNNTLLKLHDGTEFKIRASAGISWYPDDSTNYDELMRYADFAMYQIKNTIKGEVSEF
                     DINIYNKDSFLLSNREELNKLIDGQLVEYAFQPIVDCKGKVFAYEALMRPKIKTFSSP
                     IDVIRLARSQSKLYQIERITWFKALKSFKKYKEKFGDCKLFLNSIPNNNLSKVDFEEI
                     EDLYGEYLNRVVLEITENDKINEDFIEKKKAYIDHWNIEIALDDFGTGYNGDAVLLYI
                     MPDYVKIDMSIVRGIDKDENRQKILKNLISYSNERNIKVIAEGVETKGEMETLINLGV
                     DYMQGYYISKPSFIPEDISDKIKKELKICHENRNDVV"
     gene            13713..15779
                     /locus_tag="KR257_002621"
     CDS             13713..15779
                     /locus_tag="KR257_002621"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888557.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-dependent helicase"
                     /protein_id="HBH0031302.1"
                     /translation="MVELIITTNIDIRKLNENQLEAVEHIDGPCMILAGPGSGKTRVI
                     TYRIANMVVNKNIAPTRILAISFTKASSIEMKNRALNLSDDIRLNKVTYGTFHSVFFK
                     ILRYFERYNLDSIFDEKSKRMTIKAILKSLNIENADDDENIGQVINEISYVKNELMDK
                     NEFNSEVLTKDEFLKVYNLYEEQKSKVNKIDFDDMLIRTYYLLLNNKSALEMVRNVYK
                     YILIDEFQDINKVQFEVLKLICSPLNNIFAVGDEDQSIYGFRGARPDFLLEFEQYFNN
                     TKKIILDINYRSKSEIVHTANRLIDKNKNRYEKIIKCSQGDGGSVTYISPHDSEEEAL
                     YIAREIIDEIQKDYVEYSDFAVIYRTNIQSRALVDVFMDMRIPFVVKDSVITIYDHWA
                     SQDILAYLRIGINPKSNKDWLRIINKPFRYISKDSINMVKDEKDFITALINKCNLHPK
                     QVKTINDLEIDLSYLNTLNPKNAISYIRTSLDYDRYVLDYCSNRKIKTNGLVEILNEL
                     ESSATNFNTVTEFLEHIDRVKTELTENNKNKQTEGVIFTTMHSAKGLEFRNVYIIGVN
                     EGTIPHEKSYDICKEEKKEEQLEEERRLMYVAITRAEEKLCISSTLNKYGKKVDKSLF
                     INDIKSPTKKEIDSIGVGDKVYHKKFHEGEIIKKDGIMFTIKFKDRERILDLKTCLLK
                     NIIYTI"
     misc_binding    16162..16372
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00230"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="T-box leader; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /bound_moiety="tRNA"
                     /db_xref="RFAM:RF00230"
     gene            16598..17413
                     /locus_tag="KR257_002622"
     CDS             16598..17413
                     /locus_tag="KR257_002622"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418392.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transporter substrate-binding domain-containing
                     protein"
                     /protein_id="HBH0031303.1"
                     /translation="MKVFKKLLSLGLVLGLTLSLVGCSGGGEKTKLEQIKDNGKLVVG
                     TSAEFPPFEFHKVVDGKDSIKGFDIMLAEEFAKELGVKVEIKDMSFDGLIGALNADQV
                     DIVLAGMSPTPEREKSVDFSELYYLSRNAVIVKDADIDKVKTEDDLKKLRVGVQAGSI
                     QEEYVVNTLKMTTTKSLKAIPDLITELKNGNIDAVVTNEAVSLINVKKYDGIKMANTE
                     VGKDVTEGMAAAIKKSDNNKDFIELLNKKIKELQDGKKIEEFLNEASTEAASN"
     gene            17441..18118
                     /locus_tag="KR257_002623"
     CDS             17441..18118
                     /locus_tag="KR257_002623"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888558.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amino acid ABC transporter permease"
                     /protein_id="HBH0031304.1"
                     /translation="MSLDFSFLSRFGTSFLEGTGVTVSISLVALCFGFIIGIIICMAK
                     ISKSKVLRAISSIYIEVLRGTPLLVQIYIVWFGLPQLGIRFPMLFGIPSEFIASAFAL
                     SVNSGAYVAEILRSGIQSVDNGQMEASRSLGLNYWSTMRYIIIPQAIKNILPSLANEF
                     ITLVKESSIISVIGVVEIMRTADIVKNAAFRALEPLIVAAAIYFVITFTLSRLVGLLE
                     KKLSVSN"
     gene            18177..18899
                     /locus_tag="KR257_002624"
     CDS             18177..18899
                     /locus_tag="KR257_002624"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004398740.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amino acid ABC transporter ATP-binding protein"
                     /protein_id="HBH0031305.1"
                     /translation="MITIKNLSKSFGDLNVLKNIDLEIAKGEIMVIVGPSGSGKSTLL
                     RCMNLLEIPTGGEIIFEGKNLVDKKTNIDEVRQNIGMVFQNFNLFPHKTILDNITLAP
                     IKLKKMTKEEAEKKAEILLSRVGLLDKKDSYPSQLSGGQKQRIAIARALAMEPDMMLF
                     DEPTSALDPEMVNEVLDVIKELAKEGMTMAIVTHEMGFAKEVADRVIFIDGGSILEDN
                     TPEEVFGNPKHERTKAFLAKVL"
     gene            19547..20698
                     /locus_tag="KR257_002625"
     CDS             19547..20698
                     /locus_tag="KR257_002625"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902136.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cysteine desulfurase"
                     /protein_id="HBH0031306.1"
                     /translation="MEIYLDNSATTKPYQEVIDKMVYALNTEYGNPSSVHRKGVEVEK
                     AIKEVRQDIAKSLGAKEKEIYFTSGGTECNNTIIRGITSLNKKRKNHIISTNIEHPSV
                     LNTLKDLEEDGFEVTYLEVGKDGKINIEDLKNAIKSTTCLVSMMHVNNEIGTIQPIGE
                     VGKYLKGLKEKIYFHVDAIQSYGKINFRLSKYNIDFMSVSAHKFHGPKGIGFMYIKEN
                     NRLKPMLTGGGQEIGIRSGTENVPGIYGLGEAVRILNKDLDVVISKVNNLKNILKNEI
                     IDNIEDIKINSPEDGVCHILNVSFRGTKGEVLLHYLEQKGIYVSTGSACSSKKKGSYV
                     LNAIGLTNEEINGTIRFSLSDMNTEEEMLEAVKVLKESICDLRSIMKRK"
     gene            20744..21919
                     /gene="thiI"
                     /locus_tag="KR257_002626"
     CDS             20744..21919
                     /gene="thiI"
                     /locus_tag="KR257_002626"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437440.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA 4-thiouridine(8) synthase ThiI"
                     /protein_id="HBH0031307.1"
                     /translation="MVYNILIVKYGEIGVKGKNRYIFENRLIRNIRNMLKPIGRFNVY
                     KEYGRIYVDLEDYDYEEVIEEVRKVFGIVGVCPGVRAKKDYDTLKEIALKMLEEKIEA
                     GYKTFKVESRRGDKSFGLTSQEMSMDIGGYLLSKVGDRINVDVRNPEVKIKCEYREFH
                     TMVYSDTIPGYGGLPLGTNGRAMSLLSGGIDSPVATWMVAKRGMEVEAVHFHSYPFTS
                     ERSQEKVKDLAKILAKYCGRVRLHKVNILEIQKAIGENCNEEEATILSRRFMMRIAQR
                     LSEKRHCDALITGESIGQVASQTIQGLTCTNAVVDLPVFRPLIAMDKSDIVDIAKKIG
                     TFETSILPEEDCCSVFSPRKPVTKPRLEKIEKSETALDIEKLVQDAIDKIEVEDIEF"
     gene            22075..22878
                     /locus_tag="KR257_002627"
     CDS             22075..22878
                     /locus_tag="KR257_002627"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860949.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="prepilin-type N-terminal cleavage/methylation
                     domain-containing protein"
                     /protein_id="HBH0031308.1"
                     /translation="MNKKGFTLIELLVVISIIGILVIVAVPALFRNIEKSKAVTCLSN
                     RENIKTQIVIAMAEESSKGKNEVMKEVLENKDGKYFETEPKCKSGGIYSATFDDGYDG
                     ITGIESIAKVYVTCTKHPDGVEMARDIHQSMKDLIASFSQDPSIIPGASKGNDDFRKY
                     LLDNKYKNGWPTIPDEFKAKYGLSKDTLYIQPYAYSPTKSDATVVVFANNKTGGNWYT
                     SLVYDYDEGRWYKGKNGISVAGRSWDVDTDSVKSVKTEIHSKEGWGPLN"
     gene            23121..23762
                     /locus_tag="KR257_002628"
     CDS             23121..23762
                     /locus_tag="KR257_002628"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902140.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nitroreductase"
                     /protein_id="HBH0031309.1"
                     /translation="MNNNFQDNQTINLIQSRRSIRKFTTEQISDEQVNTLLHCAFAAP
                     SGCNKQPWHITVVQDQKLLKEISDDTLSRIHEVSNVEINKNFKLFYGAPTVLFISYDE
                     SSSWAPYDIGILTGNITTAAQALGLGSCIIGMVRGLFTPVEQGDIEGLVSVLDKEDVK
                     ESESIKMKFDTNKKYRELLDIPEGYSVPFGIAVGIPDGNLPNAREVVYKVSRV"
BASE COUNT         9584 a         2470 c         4339 g         7733 t
ORIGIN      
        1 tagaatattc agtaaaatga ttttgatata ctctctatat tttgtatgtt aaaagtaaat
       61 aaattattgt taaagaaggt aaagactttt aaatttctta tcataggatt ttaagtaaat
      121 aagaaggatt ggagtaatta aaaattttta ttttgcaaaa ataagtattt atttatatgg
      181 ataaatttga ttttaaatct ataaatatag ataaaatcta attatttaac ttcaactatt
      241 cctcaaaaaa gcaactttta aggaatagtt gaagcaaaaa gtttggttac ataatagtaa
      301 ttttagttac aagaatgaaa ctgtaaaact taggattttc tttatataat ttcattgaga
      361 acatttaatt taggaggtaa gatatgaaag taaaaaaatt taaaagtggt atagtaatgg
      421 cattaacagt aatggcaatt ggagcatcat tgacaaatgt atcagctatg gaattaaaca
      481 agagtaaaga gtttgaaact aaatacaatg aaatgaagat ggattttcaa gaggaatatg
      541 gaaaagaaga caaatttaat ataacattgg atgatgaatt tacaaaagaa gaagtaaatg
      601 gagctaaagg gattataaag acaactaata aaatgaataa tgaggttgta gtattaaatt
      661 attttgatga aatgaaatct ggaattgaat ttgagttgaa gccaaaagca gaaaaaaatg
      721 caattttgag agatgaattt caacaaggtt atggaaagga agataaattc aaagttgtgt
      781 tagatgatga atttacaaaa gaagaggtaa atggagctaa gggcattata aagactacag
      841 ataaagagac aggtgaggtt atcgtatata attactttga tgagcttgaa aaataatgct
      901 taaagattac tttgattgaa tgaaaaggta attgtgttga gaatataaaa tgactgaata
      961 aaaacagttg tatcaaaaca aacaataata gaatgtaaga atgattgtgt tgaaaatatt
     1021 aaatgactga ataaaaaacg attgtgtcaa aaataaaaaa taattaagtg taagaatgat
     1081 tgtatcaaga atataaaatg actgaataaa aaacgattgc gtcaaaaata aaaaacaatt
     1141 aaatgtaaga ataattatgt caaaaatata aaataaatta aaagaaaaag attatattga
     1201 aggaaaaaga tttgaaatag gggtgaactt tacatattat agttcaccct tatacaaaaa
     1261 tataaaatat aatttattat aggaaaattt aaaaaaatca gtctatttaa tttatactga
     1321 tatattgtag gattttacaa acaaactgtt atataacttt ttttatctcc aattttgatt
     1381 ttaagatatc taagaattta taacaatctt ctggatatat ttctcccata tttgctactt
     1441 ggaatatatt agcatctagg aatttacctt ttcctggata gacaacatag ccactttccc
     1501 tttctagccc taatataaac tcatttacat tgatttcttt aggtagaaat acagatgtta
     1561 ctgtattaga catatactta tctggaagta aaaatgttag acccaattct tccataccat
     1621 tccttaaaat agcagaacat tctttgtatc tttctatttt actgtcatct tccaaaaact
     1681 cagttaaagc ttcattaagg gcaaatatta aagtaacatt aggtgtattt ggtgtttgag
     1741 aagatgattt agcaacttta tagtgtttat aaagattaag atacacattc ttacattgat
     1801 tttctttaat attttgtaaa atactctctt tagcacaaag gtatgcagaa cctggaaatg
     1861 ctccaagagc tttgccacca acacctgtta ttatatctat attaaactct tccacatcaa
     1921 tatattcacc tgctgaggca cttattgcat ctacaaaaaa tattttgtta tacttcttag
     1981 caagttttcc tagttcaggg actggattta tcattcctga actagtttca tggaacacca
     2041 tagcaattac ttttatatca gaattttcaa ttatgtattt ttctaaaatg tctaggtccg
     2101 ggtattctgc ccattcaaaa ttaggtttat atgtttttac attataagta gataatattt
     2161 cttctagcct ttctccaaaa acaccattac taactagcag aactgcatct tctttgtcaa
     2221 agatagaaga tagtacacat tcatttacag atgttccaga gccagataca attaatgagt
     2281 agtaattaga agttgcatta tatagtttat tgattttttg ttgtgtatct ttgaataaat
     2341 ccataaactc atttcctcta tggcatatat catagtgaag aagtgaattt ctgactttat
     2401 ctgtaaccat tactggtcca ggactgaata gatatgtttt tttcattgta aagcctcctt
     2461 aaaaagttaa atttaaattt ttgaatgact gattatgtgt aaatattaaa atattatgtg
     2521 ttattttaac tagattatag aataaaataa taaatattgc aataatattt caataaaaat
     2581 acttttttaa tcactataat taaaaataac aaaaaatatt gtaatgaata ttgcataaat
     2641 ccacatgatg atataaaata taaataactt gaatagatta tatattcaaa aaataaaaaa
     2701 gaatttatta attctgaaaa taaaggggga catttaaagt gaaatatgta ttagcaattg
     2761 accaaggaac aacaggaaca agagcagtat tgataaacga aaaatcagag tttgttttta
     2821 gcgattatat ggaacatact caaatatatc cacaatctgg atatgttgaa catgacccta
     2881 tagaaatttg gaataataca aaaactgtga gtaataatgt attacaacag gcttttgaaa
     2941 atggaatcaa tgaaagtgat ataaaaggaa ttggtataga taatcaaggt gaaacagtaa
     3001 tgttatggga taaaaataca ggtaaaccac tttacaatgc tattgtgtgg cagtgcagga
     3061 gaacttatga ttatgtggaa aatttaaaga atataccagg tttagaaaat aagataatag
     3121 ataagactgg gttaattata gacccatatt tctcaggtac aaaaattaaa tgggtaatag
     3181 ataatgtaaa aggtgtaaaa gaaaaaatta aaaatggaga agtacttgca ggaacattag
     3241 atagttggtt aatatggaaa atgacaggag gaaaatcttt tttaactgat gtatctacag
     3301 cagcaagaac aatgcttttt aatataagag atatggattg ggatagagag ttgcttgaca
     3361 ttataggagt acctagaagt attttagcag atataatgcc tacgagtggt gattttggaa
     3421 ctacagataa ggaggcattt tgtggggttt ctataaaaat tactgcttca atggtagacc
     3481 aaccagcagc tttatttggc aatggatgtt ttgaaccagg aatggttaaa aatacttatg
     3541 gtacaggatg tttcctatat atgaatatag gtgaggaact aaatatagca ggtaatggta
     3601 ttttgacaac tgttgcttgg aaaataggag ataaagttac atatgcttat gatggtggag
     3661 tgtatatagc aggtgctgca atacaatggc ttagagatgg cattggagtt ataaaaaatt
     3721 attcagaaac tgatgacatg gcaaattcca tatcaagtac tggaggtgta tattttgtac
     3781 cagcatttgc aggtatagca gcaccttatt gggaccaata tgctagaggt acaatggttg
     3841 gaataacagg aagtactaaa aaagagcata tagtaagagc gactcttgag tctgttgcac
     3901 ttcaagtcaa agatgttgtt gattctatga acttagcctc agggaaaaaa ataaaaatgt
     3961 tgagagtaga tggtggaatt actaaaaata actttacaat gcaatttcaa tccgacatat
     4021 taggtatacc aattgaaatt gcagaaaatc ctgagacgac agtacttgga gtaggatata
     4081 tggcaggtct ttcttgtggt gtctggaaca gtattgatga aattagaagt gaatttacaa
     4141 taagcaaaaa atatattcca aatatgacta ctcaaaaaag agaagaaata ttacttggat
     4201 ggaaccaagc agtaaaaaga gctatgaatt gggaaaacga taccaaaaag gtgtgtgcta
     4261 attaagttac aatagagtat tttacatgta taggaggaat taaaaatgcc ctttgataaa
     4321 attatattat acataatggc tgtgggagtg cttttaggag cgttagatag aataattgga
     4381 aataaatttg gacttggcga gcagtttgaa gaagggttta attcaatggg tccattggct
     4441 ttaggaatgg ttggtatagt ttgtttagct ccagtaattt cagatgtact aggtcctata
     4501 ataataccaa tcttcaatct ctgtggagct gacccatcta tgtttgcaac tattttagcg
     4561 aatgatatgg gagggtatcc attggctatg gaacttgcac acaataaaga ggcaggaatg
     4621 cttgcaggat tggttgtgtc atccatgctt ggatgtacat tagtattttc aattccagta
     4681 ggactaggtc ttatagaata tgaagacaga ccattctttg caaaagggtt actgataggc
     4741 ttgataacaa taccttttgg aggtattata ggaggattaa tagcaggatt taacttatca
     4801 atggtaatta taaatatgat accagtgata atattggcag taatattggc agtaggttta
     4861 aaatttaatt ctacgcttat gataaatggg tcattagttt ttggaaaatt tatatctata
     4921 ttgataacga taggtttggg agcagcagca tttcaagaaa taacaggtat agtacttata
     4981 aaaggcatga cacctataag agaaggtatt caagtaattg gaagtattgc aatcgtgtta
     5041 ttaggtactt ttccaatatt acatttatta gttaaagttc ttaataaacc acttacaata
     5101 gtgggtggaa aattaggtat ggatgccact agtgcagcag gattagtttt tactttagcc
     5161 aatagtattc cagtatataa aatgatgaaa gatatgagtc caaaggggaa agtagtaaat
     5221 actgcttggc tggtttgtgc tacagcagct ttgggggacc atttaggatt tacagcagga
     5281 gtagttccag agatgattac acctgttgta attggaaaat tggttggagg agtattggca
     5341 attgcacttg ctatacttat gacaaaagat ttaaccttgg aagaagaaca aagtattaaa
     5401 atgaagaaag atgcagtgta gaataaacaa tacttaagtc aaatttaaat tattttaaag
     5461 taggagttta aataactaaa aataaattaa aaagacagac aattaaaaaa taatcgaata
     5521 actaaaactt ataaattaaa taaaatggca atcaaataac taaaaatgat aagctaactg
     5581 aaagtagtta cataattaaa atataaagta tagtttagac ataaatggag ctaaataaat
     5641 aattatttgg ctccttaatt ttaatttatt acatcaagga actaaaaatc aatcatataa
     5701 gctaattatc agctatgact aaaggtattc ctttttgaga aaactctatt attatattat
     5761 ggtctatact agcagaggta ataatagtat ctatatgttc tataggagct actgatgcaa
     5821 atgaatttat accaaactta ggaggttcga caactactat agattttcta gacctttcaa
     5881 tcattttttt tctaacaagt gcttcttcta agtgatagtc agagattcca ttttcaagag
     5941 tgatacctcc agcgcctaaa atagctttat caacattaaa ttgttcaata gctgacagtg
     6001 taagcggacc agaaaaagaa ccttcagttt ctctaagata gcccccaagc acatatactt
     6061 ttatattagt attcataagc tcgtttgcaa ctaaaattga gttggttatt acagttagat
     6121 tctttttatc tttcaaattt tttgaaactt caagtacagt agttccagta tccataaaaa
     6181 tagtatcatt tgtatttata aactcactac atttaatagc aatctgtttt ttatcgtttg
     6241 agtttatttt ttttctttta acatagttaa gttctacgct acttgctata actggtatag
     6301 caccaccata aactcttttt aaaagaccga tactctccat atgggctaaa tctcttcgtg
     6361 cagtttctat tgatatatca aacatttgaa ctatgtcatt tattttaatt atattatctg
     6421 atttgagaat acttaaaatc ttctcatatc tttcctgtgg taacataaaa tatcctcctt
     6481 ggactagtat tattttagtt ttggcataac ttacaattaa gtcagagttt aggtatattt
     6541 gttaatgtat gtatatttat caaataatat tataagtgtt atgcaagata attttaccat
     6601 atttaaaact tacatttaag caaaaaagta aaaatagatg tttaataatt caaaataact
     6661 caaattttat aaaacaattg actaaaatat gattttatta tataatttac tagtatagag
     6721 atatggagaa gtactcaagt ggctcaagag gatcccctgc taagggatta ggctgggtaa
     6781 ccggtgcgag ggttcgaatc cctccttctc cgccaattat taaaggctat ttttattaaa
     6841 gatagtcttt ttataatgtc ataaatgatt agatatgtat aactaaagaa aggagggaat
     6901 agatgacaac tttaattttt ttcatagtgg ggatagcatc tttggtagtt gcttttgtta
     6961 ttgatggggg acatgttgga gcattatttg tattttcatc agcacttgtt gtgtttggtg
     7021 gaactatagg agctgttgga gcttcgactc cattccctgt gtttaaaaag tctataaaga
     7081 taatgttatt aacttttaaa aataaaaagc ctaataacat agaaaatata atctatttca
     7141 aagaaattgc aacaaaggct aggaaagagg ggcttcttag tattgacaaa gaaataagtg
     7201 agaatgatga attagaccct tttattagaa aagggcttga acttatggta gatggagtgg
     7261 atgcagttac tataagaaat atattggaat cacagataca gataacatca aaacgacata
     7321 aagaaggaat agcaattttt gattcagcag gtggatatgc acctacactg gggataatag
     7381 gtacagttat gggattagta catattttag gtaatctttc aagtaatcca gatgcattag
     7441 gacctcaaat ttctgttgca tttttggcta ctttgtatgg tgttggttct gccaatttaa
     7501 tatggttacc aatagcatca aaacttaagg ctataaatca acaagaagta agtgaaagac
     7561 ttttggtgat agaagcaata ttatccatac ttgagggtga taattctaat ttaatgacag
     7621 aaaaattaaa aatattttta aattcaaaag aactaattga acttgaagaa attggtggta
     7681 gagctgaata atataaaagg atggaatgtt tatgttgtat gatgaagatg aaaaagaaga
     7741 aaacaatgag cgatggcttt taacttattc agacctcata acattactta tgattttctt
     7801 tgtaataatg tattctatga gtaatgttga tgcggagaaa tataaacaat tatctcaatc
     7861 tctaaattct gcttttggtg gttcttctgg agttattgaa ggtggtaata gcaagataga
     7921 accagtagtt gaaccaggaa gtaatgattt agatacttta caaaatgcta agtttaaaaa
     7981 aattggtgaa gaaattcaga agtatttaaa cgaaaatggt atggctaatt cagtatcatt
     8041 aagagttcaa gatagaggat tagtaataag ccttaaagat acaatactat ttgatacagg
     8101 gaaagctatt gtgaaggata attctagaga taagattatt caaataggta agatgttaaa
     8161 tgaaatgaat agttacatga gagtagaagg ccatacagac aatatgtcta taaaaaattc
     8221 agagtttaag tcaaattggg atttatcagt tatgagagca accaatgttg ttcaacttct
     8281 tattgacaat gcaggtatag caccagataa attatctgct gtaggatatg gtgagtttag
     8341 accaatagca gaaaattcat ctgaagaagg taggtcaaaa aatagaagag ttgatatagt
     8401 tttagttgat agtaaatatg ataatgtaga aaatgtttca aaggataaat agttaaatta
     8461 gctgtctcaa tacagaatta attctaaagg agatggcttt tttatgcgaa aatcaaaaat
     8521 agatacatag taagttacct ttttgtagga atatatggta tcttaaatat ataatattta
     8581 aataatgtat aagctcaatt aaaaaattta tagaggatgg aaaataaatg ggaaataaaa
     8641 ataaaaatac taaatataaa gataaaacaa gagaaaggta taataaaaaa gttgagaatt
     8701 taaataaaga aaaattaaat aaaattaata agcaatctaa gaaagtagat aagattgatg
     8761 atattattaa taaatctagt attgtattat gtgtacttct agtagtgttt tcattgcttt
     8821 acttatttaa actggttcaa cttaatataa taatgatact tttagtaatt acagtagcta
     8881 ttcaacaagg attggtgtca tttggtgcat ttagaaataa aaattatgta aaagctttat
     8941 tttctatatt tgtaatagta tgtttcttaa ttgcttttaa atatgttgta aatcctgttt
     9001 aaatatatca ataaacgttc tataattaat ataaatagtg aagttacagt tttaatgcta
     9061 ttataaattt tataatttga aggagtagat tttatgaata ggtgtaagtt tgcaaaatta
     9121 attatcacat caatgattgt tttattactt acaggatgta gtttaaagaa ggaagataat
     9181 tataagttag acccagaaaa tccgacatca atacaaattt ggcattatta taatggacag
     9241 cagaaaatgg cttttgataa gcttgttaag gaatttaatg acactgtagg tgctgaaaaa
     9301 ggaattattg ttgaagcatt cagtcaaggt aatgtagttg atttatcaga gaaagtttta
     9361 gattctgcaa ataaaaaagt tggttctgaa gatgtaccaa atatatttgc agcatactca
     9421 gatactgcat atgaaatgga taaattaggg ttactagtag atatggataa gtacataagt
     9481 aaagaagaat taaatgaata catagacgaa tatgtagaag aaggcagaat aaattctaag
     9541 gatgagttta aacttttccc aattgcaaaa tcaactgaaa ttttgatgtt aaataaaact
     9601 gattgggata aatttgcaaa agctacaaat tcaaatataa atgatataaa aacaattgaa
     9661 ggattagtag agacatcaaa aaaatattat gaatggacag atagtttaac gaaagagcct
     9721 aatgatggta aagcattttt tggaagagat gctttagcaa attatattat tataggaagt
     9781 aaacaactag gagtagaaat tttttctgtt aaagatggta aagttacact aaatattgat
     9841 gaaaaagtta tgaaaaaact atgggataat ttctatgtac catatataaa tggatatttt
     9901 gcttcttatg gtaagtttcg ttctgatgat gcaaaaacag gtgatatatt agctcttgta
     9961 ggttctagtt caggagcagc atactttcca gatagagtaa tgctaaatga taatgagagt
    10021 tataatattg aaacatctgt ttttcaagca ccacgtttta aaggagaagg aaaatatgct
    10081 gtacaacaag gtgcaggaat ggctgtaaca aaatctacta aagaagaaga atatgcatca
    10141 gtagaatttt taaaatggtt tacagataaa gaacctaata taaaattctc tattgcttct
    10201 ggatacttac cagtaaagaa aaaaacgaat gatttggatg ttataaaaga agttatgaag
    10261 aaagataatt tgagtttatc tgataaagtt gaaggttcaa tagcctcatc tattgaacag
    10321 attaacagtt gtaatttata tactaataaa gcatttgatg gtggaactaa agctagacaa
    10381 atacttgaat attcaatgct tgataaagct aaagaagatt caaataaaat aaatgaatta
    10441 gtaaaaagtg gaacttctaa gaaggatgca gtagcacaat ttaataatga taaaaatttt
    10501 aaaacttggt ttgaaagttt taaggctgag cttgaaaatg ctataaaaaa atagatgaat
    10561 tggcagttag tgtgttgacg agcacaaagg tataggtgga atgggtatgg aaaacaatct
    10621 aagaaaaaac aattcaataa tgaaaaagat gatatttccc ctaattattg ttatgctaat
    10681 tcaaacaagt ttattttgtg ccacaatttt atggggagga actattaaga aattaaatga
    10741 taattcgttt gacatcttaa atgaaagagt aattaatcgt aaaaattata tacaaaatga
    10801 aatgttacaa agatggtcaa atacaagtga aacggaagct acaattaatt cctctgtaaa
    10861 aaaagtatta aatgaaaaaa atgccttaat tgaggatgta ggcaacaatg aagaaattaa
    10921 caaagatatt ataaaaagca tatcaaatga tttaatatat cttttgagaa aaaattctgt
    10981 tacaggagct tttataatcc taagtgacaa aaatattaac gataagtcaa tagatagtaa
    11041 aggtgaaata agtaggacag gattgtatat aagggattta gaccctaagt ttaatccaaa
    11101 tgataattct gatttgttaa ttgagagagg ttcatcagat atagcaagaa gttttggaat
    11161 atctatggac agttattggg aacctaagtt ttcatttaaa agtgaaaatg agcaagatgg
    11221 agatgatttt ttttataaac catttagagc tgcaattgat aatccaaatg tatcaagttc
    11281 taatttagga tactggggaa gtaagttttt attgacaaat gcaggtgata ggcttatgac
    11341 atatacagtt ccccttattt atgaagatgg aactgtatat ggagtacttg gaatagattt
    11401 aagtgtaaat tatttaagag aattacttcc atactcagag ataaatggaa ataaaaaggg
    11461 taattatatt ttaggtgtag atagaaataa tgatatggcc tttgaaaatg taatttcaaa
    11521 tggatactca ttaaaagaaa aattttggga tggtttacat tctaatttag agcagaagga
    11581 atcgtataaa aatatatata agattaaaaa taaagataat gaatgtggta atggcaacat
    11641 ttatgctagt gtacaatact tggatttata taactccaat actccatttg aaaatgaacg
    11701 ttgggctctt ttgggtatta ttgaagaaaa aagtcttttg tcattttcaa aaagggtaga
    11761 gaaattagtt ataatatcta tagcaatttc tttattaata ggtctaatag gtatttacat
    11821 tgcatcaaga ttatttacaa aaccaattgt tcttttagcc aacaaagtta gaaacagtaa
    11881 tccatcaaaa ccagtaaatc ttgataagat aaatatatct gaaatagatg aattatcttc
    11941 agctatagag ttgctcagtg caaatgttgc agattcttcg tcaaaattat cacagattat
    12001 tgaaatggta gatatgccaa ttggggcttt tgagttatac aaaaacgcag agaatgtttt
    12061 ttgtacaaaa gaatttttta gcgtgtttac tactgaaatc aaatttgaag aatatggata
    12121 tatggaaaaa aataagttcc tgaaaaaatt aaggggacta gataaatatt tgcaagaaag
    12181 ttatgaaaca gaaaatacat atatatataa gtttgaatct aaagataaaa aacttaagtg
    12241 gataagaatg aatatctttg aagatgagct aaaggttctt ggtgttgttg ttgatgtcac
    12301 aaaagaattt attgagaaaa ggaagataga atatgaaaga gattttgata ttttaacgaa
    12361 tcttttaaat aggagagctt ttcattcaca gatacaagaa aaatttaaga ataaagatga
    12421 acttaagata gcagcattta ttatgtggga tttagataat ctaaaatata ttaatgatac
    12481 atatggacat gatgctggtg atgaatatat taggtgtgct gcagacatac ttaagaagtt
    12541 tatatcatgg aatggtatag tatctagact ttcaggtgat gagttttatg tatttatata
    12601 tggatatgaa agcaaagata gtataagaga tattattaat tctgttaaga aacagatgaa
    12661 taatacctta ttaaaacttc atgatggaac agaatttaaa ataagggcat cagcaggaat
    12721 ttcctggtac cctgatgact caaccaacta tgatgaatta atgagatacg cagattttgc
    12781 tatgtatcaa attaaaaata caatcaaggg tgaagttagt gaatttgata ttaatatata
    12841 taataaggat tcattcttat tgagtaatag agaagaatta aacaagttaa ttgatggtca
    12901 attagttgag tatgcatttc agcctattgt agattgtaaa ggtaaagtat ttgcatatga
    12961 agcacttatg agacctaaaa taaaaacttt tagttcacca atagatgtca ttagattagc
    13021 tcgttcacag tctaaattat atcaaattga gcgtattaca tggtttaaag cacttaaatc
    13081 atttaaaaaa tacaaagaaa aatttggcga ttgcaaattg ttcttaaatt ctattcctaa
    13141 taataatttg tcaaaagtag attttgagga aattgaagat ttatatggtg aatatttaaa
    13201 tagagtagta ctagaaataa cagagaatga taagattaat gaagatttta ttgaaaaaaa
    13261 gaaagcatat atagaccatt ggaatataga aattgcttta gatgattttg ggacaggtta
    13321 caacggagat gctgtactat tatatataat gccagactat gtaaagattg atatgtctat
    13381 tgtaagaggt attgataaag atgaaaacag acagaaaata ttaaaaaatc ttatctcata
    13441 ttctaacgaa agaaatatta aagtgatagc agaaggtgta gaaacaaaag gtgaaatgga
    13501 aacactaatt aatcttggag tagattatat gcaaggctac tatattagta aaccatcatt
    13561 tatacctgaa gatataagcg acaaaattaa aaaagaactc aagatatgtc atgaaaatag
    13621 gaatgatgtg gtttaataga ggaaaaatta aatttatttt tatgaacttt tagtttataa
    13681 ttaaaaagaa aataatataa ttataaatca aggtggtgga gctaataatc acaacaaata
    13741 tagatataag aaagttaaat gaaaatcaat tagaagcagt tgagcatata gatgggcctt
    13801 gcatgatact tgcagggcct ggttcaggta agaccagagt aattacatat agaatagcca
    13861 atatggttgt aaacaaaaac atagcaccaa caagaatctt ggcaataagt tttaccaagg
    13921 catcttcaat agaaatgaaa aatagagctt tgaatttaag tgatgacata agacttaata
    13981 aggtaaccta tggtactttt cactctgtat tttttaaaat tctaagatac tttgaaagat
    14041 acaacttaga cagtatattt gatgaaaagt caaagcgaat gacaatcaag gcaatcctaa
    14101 aaagtttaaa tatagagaat gctgatgatg atgagaatat aggacaagtt ataaatgaaa
    14161 tttcctatgt aaaaaatgaa cttatggata aaaatgaatt taattcagaa gtattaacaa
    14221 aagatgagtt tttaaaagta tacaacttat acgaagaaca aaaatctaaa gttaataaaa
    14281 tagattttga tgatatgctt ataagaactt attatttact tttgaacaat aagtctgcac
    14341 tagaaatggt tagaaatgtg tataaatata tattgataga tgaatttcaa gatataaata
    14401 aagtacagtt tgaagtttta aagttaattt gtagcccatt aaacaatata tttgcagttg
    14461 gagatgaaga ccaaagtata tatggattta gaggtgctag accagatttt ttgcttgaat
    14521 ttgaacaata ctttaataat actaaaaaaa taatattaga tataaattac aggtctaaaa
    14581 gtgagatagt gcatactgca aatagactta tcgacaaaaa taaaaataga tatgaaaaaa
    14641 tcattaagtg tagtcagggg gatggaggaa gtgttaccta tatttctcca catgattcag
    14701 aggaagaagc cttatatatt gccagggaaa taattgacga aatacaaaaa gattatgtag
    14761 agtattcaga ttttgcagta atttatagaa ctaatataca gtcaagagca ttagtagatg
    14821 tatttatgga tatgaggatt ccatttgtag taaaagactc agtaattaca atatatgacc
    14881 attgggcaag tcaagatata ctagcctatt taagaatagg tattaatcca aaatcaaata
    14941 aagattggtt gagaattata aacaagcctt ttagatatat atccaaagac agtataaata
    15001 tggttaagga tgaaaaagac tttataacag cattaataaa taagtgtaat cttcatccta
    15061 aacaagttaa aacaataaat gatttggaaa tagatttaag ttatttaaat actttaaatc
    15121 ctaaaaatgc aatatcttat attagaacta gtcttgatta tgatagatat gttttagatt
    15181 attgtagcaa cagaaagata aagactaatg gacttgtaga gatattaaat gaacttgaga
    15241 gttcagcaac taattttaat actgttacag agtttttaga gcatattgat agagtaaaga
    15301 ctgagttaac ggaaaataac aagaataagc agactgaggg tgtcatattt acaactatgc
    15361 atagtgcaaa aggattagaa tttagaaatg tttatattat aggtgtaaat gaaggaacaa
    15421 tacctcatga aaaatcatat gatatttgta aggaagagaa aaaagaagaa caattagaag
    15481 aagaaagaag acttatgtat gttgctatta caagagctga agaaaagtta tgtataagct
    15541 ctactttaaa taagtatggt aagaaagttg ataaatcatt atttattaat gatataaaat
    15601 ctccaacgaa aaaagaaatt gacagtattg gtgtagggga taaggtatac cataaaaaat
    15661 ttcatgaagg agaaataatt aaaaaagatg gaattatgtt tacaataaag tttaaagata
    15721 gagagcgaat cttggatttg aaaacttgtt tattgaagaa tataatttat actatttaat
    15781 ttagaatcta aatttagata gaaatataat gtattattta ttatgtgcaa gacaaataga
    15841 tatgtgtaaa atgtattatt taacttatta gaaaaagaaa taagggttta atatattatt
    15901 tatagttgtt tagaaaaagc aacaatgtgg aaaatattat ttagtattat taaagaaaag
    15961 caacaatgtg aaagatatta tttagtatta tttaagaaat agctaaaaat atgaaatata
    16021 ctatttataa ttacacaaat aatatcaata aatataaaca gtagtattta gataatttac
    16081 aagtaaaaat tattaaaaaa ataaaaaact tattgacaaa aatattataa ggaagtacaa
    16141 ttgtattaac aatttaagga aacaaatcca atgatagaga aagtagcata tatggattta
    16201 cagcgagtta ggggttggtg taagcctaac aatgaagtct atgtgaagag agctctggag
    16261 gagattatca gaaactttag tatgataatt ggtttacccg ccttaaggga ttgagaggat
    16321 aagtacttac ttatcaaaaa gagtggtaac gcggatataa ttcgtctctt agctgtaaag
    16381 ctaagggact tttttgattt taaaataaaa atatccatac agcttaaaag ctaacagtca
    16441 caaattttga aagtaatata agtatttatc aataagagtg gtaacgcggt aaagtcgtct
    16501 cttagtcatt aaagactgag agactttttt tgtaactcga aacatttaag tattaaaatc
    16561 tgagggaaat tataattaaa agagaggggt agttaaaatg aaagtattta aaaaattatt
    16621 aagtttagga ttagtattag gattgacatt atcgctagta ggatgtagtg gtggaggaga
    16681 aaaaacaaag ttagaacaaa taaaagacaa tggaaaatta gttgttggta ctagtgcaga
    16741 atttcctcca tttgaatttc ataaggtagt agatggaaaa gattcaataa aaggattcga
    16801 tataatgttg gctgaagaat ttgcaaaaga gcttggtgta aaggttgaaa ttaaggatat
    16861 gtcatttgat ggattaatag gtgctttaaa tgcagaccaa gttgatattg ttcttgcagg
    16921 tatgtctcca acaccagaga gagaaaagag tgttgatttt tcagaattat attatttaag
    16981 tagaaatgca gttatagtta aagatgcaga tatagacaaa gtaaaaactg aagatgattt
    17041 aaagaaactt agagttggag ttcaagcagg aagtatccaa gaagaatatg tagttaacac
    17101 tttaaaaatg acaactacaa aatctttgaa agcaatacct gatttaatta cagaattaaa
    17161 aaatggaaac atagatgcag ttgttactaa tgaagcagtt tctttaataa atgttaaaaa
    17221 atatgatgga ataaaaatgg caaatactga agttgggaaa gatgtaacag aaggtatggc
    17281 agcagcaatc aaaaaatctg acaataacaa agattttata gaattattaa acaaaaagat
    17341 aaaagaatta caagatggca agaagataga agaattttta aatgaagcat ctactgaagc
    17401 tgcttcaaat tagtaagaaa gttatgtggg agatgaaatt atgagtttag attttagttt
    17461 tttaagtaga tttgggactt cttttttgga aggaacaggt gtgacagtat caatttctct
    17521 tgtggcatta tgctttggat ttataatagg tataattatc tgtatggcaa aaatatcaaa
    17581 gagcaaagta ttaagagcaa tatcatcaat ctatattgag gttttaagag ggacaccatt
    17641 attagtacag atatatatag tatggtttgg tttacctcaa ttaggaataa gattccctat
    17701 gttgtttggt ataccaagtg aatttatagc tagtgcattt gcattatcag taaactctgg
    17761 tgcatacgtg gcagagatac ttagatcagg tatacaatca gttgataatg gacaaatgga
    17821 agcaagtaga tcattaggat taaattattg gtcaactatg agatatataa taatacctca
    17881 agctataaaa aatatattac cttcattagc aaatgagttt attacacttg taaaagaatc
    17941 ttcaataata tctgtaatag gagttgttga gataatgcgt actgctgata tagtaaaaaa
    18001 tgcagcattt agagcattag agccattaat agtagcagca gcaatttact ttgttataac
    18061 atttactcta tcaagattag ttggattatt agaaaagaaa ctatctgtgt ctaactagat
    18121 gagagcatgt ttagcattta gggaaaacat agaatagtaa aaaggaaagt gataatatga
    18181 ttacaataaa aaatttaagt aaatcttttg gagatttaaa tgtattaaaa aatatagact
    18241 tagaaatcgc taaaggcgaa ataatggtta tagtaggtcc aagtggttct ggtaaaagta
    18301 cacttcttag atgtatgaat ttactagaaa tacctacagg tggagaaata atatttgaag
    18361 gaaaaaattt ggtcgataaa aaaactaata ttgatgaggt tagacaaaat ataggtatgg
    18421 tgtttcagaa ctttaattta ttcccacata agactatttt agataatata acattagcac
    18481 caattaaatt aaaaaagatg actaaggaag aagcagaaaa aaaagcagaa attttgttga
    18541 gtagagttgg tcttttagat aaaaaagatt catatccatc acaattatct ggaggacaaa
    18601 agcaaagaat agcaatagct agagcacttg ctatggaacc agatatgatg ttgtttgatg
    18661 agccaacatc tgctcttgac ccagaaatgg taaacgaagt tttggatgtt ataaaagaac
    18721 ttgctaaaga aggtatgaca atggcaattg taactcatga gatgggattt gctaaggaag
    18781 ttgcagatag agttattttt atagatggag gaagtatact tgaagataat actccagaag
    18841 aagttttcgg aaatccaaaa catgaaagaa caaaagcgtt tttagcaaaa gtgctataat
    18901 atataaaaag gatgttattg atattagaaa ttcaatacat ccttttttag tgatggttaa
    18961 tattaatttt aaaattaaag ttatattaat attaacttta tttttacgat tttttgcaga
    19021 aaaaaaaaga gctcggggta agctcttttt ttccaccgaa ttaatttccg ttactaatcc
    19081 gatttttaat aaatataaaa tatatcctta tgaaagggta ttgggaatag atatattaac
    19141 taactagggt taccaggggg ataaccttaa tttattataa caaaatgcga cacaaaaatc
    19201 aatatttttt ttgaaataaa ttataaaagt tatttttata acaagtaagc ttataaattt
    19261 aacttttata gtaaaaataa gtatatgtat aatataatat atttatttta tataatatat
    19321 tattttatca tatattgtat tttataatat atttttgtag ggtatagtat aagtatatta
    19381 tattttacta taaaaatttg taataaagtg aaaaaactag cttttcatga aataatattt
    19441 tataatttaa gattgtcttt ttaataaaga ttaacaaaaa aaatactata attagtggta
    19501 taatagttag agttgaagat tttaaataaa ggtaggtgta attaagttgg aaatatactt
    19561 agacaatagc gcaactacaa aaccttatca agaagttata gataaaatgg tttatgcact
    19621 taatacggaa tatggaaatc cttcttctgt ccatagaaaa ggtgtagaag ttgaaaaagc
    19681 tataaaagaa gtaagacaag atatagctaa atctctagga gcgaaagaaa aggagattta
    19741 ttttacatca ggtggtacag agtgtaataa tactataata agaggtatta ctagtttaaa
    19801 taaaaaaaga aaaaatcaca taatatctac taacatagaa catccttctg ttttaaatac
    19861 attaaaagat ttagaagaag atggttttga agtaacttat ttagaggtcg gaaaagatgg
    19921 gaaaataaat atagaggatt taaaaaatgc gataaagtca actacatgct tagtaagcat
    19981 gatgcatgtt aacaatgaaa taggaactat acagccaata ggtgaagttg gaaagtattt
    20041 gaagggttta aaagaaaaaa tttatttcca tgttgatgct attcagtcat atggaaaaat
    20101 taattttaga ctatctaaat acaatataga ttttatgagt gtaagtgcac ataaatttca
    20161 tggtccaaag ggaattggat ttatgtatat aaaagaaaat aatcgcctta agcctatgtt
    20221 aacaggtggt ggtcaggaaa ttggaattag gtcgggaaca gaaaatgtac ctggaatata
    20281 tggtcttgga gaagctgtta gaatactaaa caaagattta gatgttgtta tttcgaaagt
    20341 aaataactta aaaaatatat taaaaaatga aataattgat aatatagaag atataaaaat
    20401 taattctcca gaagatggag tatgtcatat attaaatgta tcatttagag ggacaaaagg
    20461 agaagtttta cttcattact tagagcaaaa gggtatttat gtatcaactg gctctgcatg
    20521 ttcttctaaa aagaaaggta gttacgtatt aaatgctata ggtcttacaa atgaagaaat
    20581 aaatggaaca ataagattta gtttatctga tatgaataca gaagaagaaa tgttagaagc
    20641 tgtgaaagtt ttgaaagaat caatttgtga cttaaggtca ataatgaaaa gaaaataaag
    20701 aatactgtat agatagtgat aataaattag tttaagaggt gaaatggtgt ataatatatt
    20761 aatagtaaag tatggagaaa ttggagtaaa aggaaagaat agatatatat ttgagaatag
    20821 gcttataaga aacataagaa atatgttaaa accaattgga agatttaatg tatataaaga
    20881 gtatggaaga atatatgttg atttagaaga ctatgattat gaagaagtaa ttgaagaagt
    20941 tagaaaagta tttgggatag tgggtgtgtg ccctggagta agagctaaaa aagattatga
    21001 tacattaaaa gaaatagctt taaaaatgtt agaagaaaaa atagaggctg gatataaaac
    21061 ttttaaggta gagtcaagaa gaggagataa gtctttcggg ttgacttctc aagaaatgag
    21121 tatggatata ggtggatact tattatcaaa ggtaggagat aggattaatg ttgatgtaag
    21181 aaatccagaa gttaaaataa agtgcgaata cagagaattt catactatgg tctatagtga
    21241 tactatacct ggatatggtg gattgccact tggaacgaat ggtagagcta tgtctctttt
    21301 atcaggaggt atagatagcc cagtagctac atggatggtt gcaaaaagag gtatggaagt
    21361 agaggcagtt cactttcata gttatccatt tacaagtgaa aggtcacagg aaaaagttaa
    21421 ggatttagct aaaatactgg caaaatactg tggtagagta aggcttcata aagttaatat
    21481 cttagaaata caaaaagcaa ttggcgagaa ttgtaatgaa gaagaagcta ctattctttc
    21541 aagaagattt atgatgagga tagcacagag actttctgaa aaaagacatt gtgatgcttt
    21601 aattacaggt gaaagtattg ggcaggttgc atctcaaact atacaaggac ttacttgtac
    21661 taatgccgtt gtagacttac cagtgtttag accacttata gcaatggata aatcagatat
    21721 agttgatata gccaaaaaaa tagggacttt tgaaacatct atattgcctg aagaagattg
    21781 ttgtagtgta ttttctccta gaaagcccgt cactaaacct agattagaga aaatagaaaa
    21841 atctgaaaca gcacttgaca ttgaaaaatt agtacaggat gctattgaca aaatagaggt
    21901 agaggatatt gagttttagc atacaagtta tttaattact aaattgaata ttgagtatat
    21961 tagtagttct gtaagtatat tagtagttct gttgaaagga tttatgtaga caatttatta
    22021 atatgtagta tttaaaaata agtactataa ttttatttaa tgggaatgat tattatgaat
    22081 aaaaagggtt ttacactaat tgaattgtta gtagttatat ctataatagg cattttagtt
    22141 atagtagctg ttccagcatt gtttagaaat atagaaaaaa gtaaagcagt tacatgtctt
    22201 tctaatagag aaaatataaa gactcaaatt gttattgcaa tggctgagga atcaagtaaa
    22261 ggcaagaatg aagtcatgaa agaggtatta gaaaacaaag atggtaagta ctttgaaaca
    22321 gaaccaaagt gtaagtcagg tggaatatat tcagcaacgt ttgatgatgg ttatgatgga
    22381 ataactggaa tagaaagcat tgcaaaagtg tatgttactt gtacaaaaca tccagatggt
    22441 gttgaaatgg ctagggatat acatcaaagt atgaaagatt tgattgcatc attttcacaa
    22501 gacccttcta taataccagg agcctcaaag ggtaatgatg attttagaaa atatttatta
    22561 gacaataaat ataaaaatgg gtggcctaca attccagatg aatttaaggc aaaatatgga
    22621 ttaagtaagg atacactata tatacaacca tatgcatata gtcctactaa atctgatgct
    22681 actgtagttg tatttgcaaa taataagact gggggtaatt ggtatacttc cctagtttac
    22741 gattatgatg aaggtagatg gtataaaggt aaaaatggta tttctgttgc aggtaggtca
    22801 tgggatgttg acacagatag tgttaagtct gtaaaaacag agattcattc taaagaggga
    22861 tggggtcctt taaattaata tatcatgttt tattaatctg gtattgatta aactatagaa
    22921 aagagcagtt tctatagatg acgaatacca gattttcatt tatatatata attgagatat
    22981 attaaaagtg tttatatttt taagtcttca catacaagct aaaaataatt ataataatat
    23041 tgtaaagaaa tttaattata agattaattt tctgaagatt tagtatttgt actaagaaat
    23101 acataaaaag gggaatagat atgaataata attttcaaga caaccaaaca ataaatttaa
    23161 tacaaagtcg tagaagtata cgaaaattta cgacagaaca aattagtgat gagcaagtaa
    23221 acacattatt acactgtgca tttgcagcac cttcaggatg taataaacag ccttggcaca
    23281 taactgttgt gcaagaccag aaacttttaa aagagattag tgatgatact ttatctagga
    23341 ttcatgaggt gagtaatgtt gagataaata aaaactttaa gttattttat ggtgctccaa
    23401 ccgttttatt tatttcttat gatgaaagta gttcatgggc tccatatgat ataggaatac
    23461 ttacagggaa tataacaaca gctgcacaag cactagggct tggaagttgt ataataggaa
    23521 tggttagagg tttatttaca cctgttgaac aaggggatat tgaaggtctt gtgagtgtat
    23581 tggataaaga agatgtaaaa gaatcagagt caataaagat gaagtttgat acaaataaaa
    23641 aatacagaga actacttgat ataccagaag ggtattctgt accatttggt attgctgtag
    23701 gtattccaga tggaaattta ccaaatgcta gagaggtagt ttataaagtt tccagagttt
    23761 aggataaagt attgcaagaa ccaatcagtt acttgaagaa ttaaaccagt aatatacaaa
    23821 taaattgatg gaagaggaag ctatttaaaa agtagtttag atttttcgtt gtaaaataat
    23881 taaataaaga ataaggtgat aagtatttta tttattatct tattcttttt tatttttgtt
    23941 ttgtagaatg ataaaaataa ggattaagtg taataaaata gaaaacaagt atgttaattt
    24001 taagtatatg ctttaaaatt tatccaagtt aaaaatttaa gatatctttt cagtataatg
    24061 gaaaaaatgt caaaatattg aaatagggaa aaaatagtga tataataaga aaaaatagag
    24121 aaaaaa
//
LOCUS       DAEPID010000059        23638 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.059, whole genome shotgun sequence.
ACCESSION   DAEPID010000059 DAEPID010000000
VERSION     DAEPID010000059.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 23638)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 23638)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..23638
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.059"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            complement(336..512)
                     /locus_tag="KR257_002629"
     CDS             complement(336..512)
                     /locus_tag="KR257_002629"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729350.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0031310.1"
                     /translation="MFRDKMDRCTHMLTAYIGSSYDYCDFIDTQLDDFILEYGENVVE
                     SCLHQVMVLVSKYN"
     regulatory      complement(566..662)
                     /regulatory_class="riboswitch"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF01051"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="cyclic di-GMP riboswitch class I; Derived by
                     automated computational analysis using gene prediction
                     method: cmsearch."
                     /bound_moiety="cyclic di-GMP"
                     /db_xref="RFAM:RF01051"
     gene            1459..1860
                     /locus_tag="KR257_002630"
     CDS             1459..1860
                     /locus_tag="KR257_002630"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429137.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RNHCP domain-containing protein"
                     /protein_id="HBH0031311.1"
                     /translation="MNYKNRKRAYYQENSCMDNFICKNCGCLVVPEGAGTQHRNHCPH
                     CLHSLHVDIIPGDRAADCDANMEPIGVWVRKNGEWAIIHRCTRCGHLSSNRIAADDNS
                     VKLMSIALKPLAQPPFPLERIIEKLEKEETE"
     gene            1857..2924
                     /gene="rsgA"
                     /locus_tag="KR257_002631"
     CDS             1857..2924
                     /gene="rsgA"
                     /locus_tag="KR257_002631"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898525.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribosome small subunit-dependent GTPase A"
                     /protein_id="HBH0031312.1"
                     /translation="MNGMKQINLQDYGLNRNFITQSMEYHDLYLARIISQEKNFYQAV
                     CVNGVLFAEVSGKLRFEATIQSDFPTVGDFVMLDRCNNKNGNAIIHHVLHRKSLFVRK
                     AAGKVNEEQVVAANIDIVFLCMSLNKDFNIHRLERYLSLTWESGAIPVVVLTKSDLCD
                     NVHRKLQVVNSIALGVDVVVTSSIEPDGYKQISKYIKPGCTVALLGSSGVGKSSLINC
                     LMGGEFLNTKEIRIDDDKGRHATTRRELFLISGGGIVIDTPGMRELGMWDVSEGLDKS
                     FADIEAYFGKCHFRNCTHTSEPGCAIWEAIAHQELSPKRWESYRRLKTEAVFADNKSE
                     YLAKKEKKFKNISKINKKIRR"
     gene            3460..4158
                     /locus_tag="KR257_002632"
     CDS             3460..4158
                     /locus_tag="KR257_002632"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898524.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0031313.1"
                     /translation="MKISSQYRSQYSFRYESNINNTRINESMVKKNETVGKDTYLSNI
                     MKQKQELNDRIRDLKYRQEVYTKKINDAIKNLCKSEIRETTNNFSNIEIGIKNSIIEE
                     KNKSTMLDENSTYLNTNDEKESLITKESNEKIEEEILNDEKLEELEQKKDYKEDSNKK
                     EKVSEDLSLVGKTREELENMLKNFINLTQEEIMKLESRIEKLDKNAEEYKQNSKTNIF
                     DKTDEQKKHINVLI"
     gene            4336..5226
                     /locus_tag="KR257_002633"
     CDS             4336..5226
                     /locus_tag="KR257_002633"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861935.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0031314.1"
                     /translation="MKKNILTTMITMIIILMMSMTVMAEPYQEDETSSLKKQSANERN
                     QTNIGTMDGRVQTNAISKGANYDPKYPLKGMLTQLGLNTTGKEGWDLLYGGNPNGVEL
                     RADGKYYYINKGMEGLGFYAAALSGGSYQRIGFGKLDPIEVIADGNWISYKQAQDTLT
                     VIRNFLNSFDWRNASEMERANRAAKLVTEAKYADSKYCNIVYGNLVDKRGVCGSFASS
                     FHLLTRLMGMDSLSILNPSLNHAWNYIQIDGKWYRFDGSEISAFGGSLDFDYRKLKDA
                     TREMTTYYDAKALSILGFNQ"
     gene            complement(5619..6575)
                     /locus_tag="KR257_002634"
     CDS             complement(5619..6575)
                     /locus_tag="KR257_002634"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891838.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="diguanylate cyclase"
                     /protein_id="HBH0031315.1"
                     /translation="MENNTIQKQLRDLSKKIWHIYILNPEEENLKFIISLLDDNLALI
                     GTGKHEFYETLEEFIIGLEKDQTESEQIDFEIIDEWYSCTKVTDEAFIVYGTLWVIEK
                     DYLEKDIYVEMDTRFTMVYRVTDDMIKLIHVHHSIPNFDQMKDEYYPKTITEKAQEAL
                     AMANEFKLKSEKDLMTGLYNRHFFEVHIKEMLKTVSHGYFYIFDLDNFKQVNDIFGHV
                     RGDEILIHFSNILTKVFVNDAIIGRLGGDEFAVFEYSNQSKENVENKAKKVLELCLES
                     NSCSIGISKLENNSDTFQSLYKQSDYALYYSKRNNKGNFSWF"
     gene            7278..8273
                     /locus_tag="KR257_002635"
     CDS             7278..8273
                     /locus_tag="KR257_002635"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729352.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="HBH0031316.1"
                     /translation="MSIIELNELTKSYRRFEKKAGFMGSVKSLFNRKYTEKTAISSFD
                     LKIEEGEFVGLIGQNGAGKTTLIKMLTGIIAPSSGEISVMGYYPNKLENNFKKQYAVV
                     MGQKSQLFFELTPADTFLLFKELYDISNEEYKKNLDYFIELFEVSDYLNVQVRTLSLG
                     ERMKMELIVALLHNPKILFLDEPTIGLDAIAQKQIRYFLKEVNETKGTTIILTSHYME
                     DIKSLCSRSIVVENSRKIYDGSTEKLFNYFQKYKKITVSFSNETNIVFPKDCKVVEQT
                     NHKISVIVPKERGNETIKWIFDKYDVKDVMIEEEDIGSIVERIYKKGSDEYYEQL"
     gene            8251..9114
                     /locus_tag="KR257_002636"
     CDS             8251..9114
                     /locus_tag="KR257_002636"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003417001.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC-2 family transporter protein"
                     /protein_id="HBH0031317.1"
                     /translation="MSIMSNYNEASSNDSMFYKFKQSIRRYYEVAKINFKVQLIWRFD
                     VVVNMVFTIVKILFAYILWKAIFGENKIVSGFTFNSMLSYYIISSFLAGIDMSKSTSE
                     EICNRVKLGTFSKYMIIPINVQNYFIAKNFGMTCFYFVFNMISAFVWIFIFKIDFAFT
                     SNPVQILISILMIFLGFIFMMKLHFFIGILSFKFLEISFLKMIIENIVEFITGTMIPL
                     VLLPETIVTVMKVFPFYYTTYLPSMLLIGRNSNEAIQGLIILALWVLFFSVVNKVMYK
                     RMRTLFDGVGI"
     gene            9111..9905
                     /locus_tag="KR257_002637"
     CDS             9111..9905
                     /locus_tag="KR257_002637"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429144.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC-2 family transporter protein"
                     /protein_id="HBH0031318.1"
                     /translation="MMKKNLKIIFMLLKMKLSKMMVFRFDFFGAFFVDSSLFILQLLM
                     FNSIYSHVDSIGGWQQGEMLIFIGTFSLINAINMTIFFFGIYDIPRKIQEGELDYYIT
                     KPLDPLFRLTFENINIGSSPLILASILIVLYGISELNSEITLVMIIIYIFMVLLMTLL
                     FYDVCIILRTVSFFVISSSAIMRLEDNLLPMNMKIPGVIYEGIFKVLFYLILPYGIMS
                     TIPTQILAGTITINGLIYSILIVFLFTLFMWRFWKLGMRHYKSASS"
     gene            10190..11569
                     /locus_tag="KR257_002638"
     CDS             10190..11569
                     /locus_tag="KR257_002638"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436224.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MATE family efflux transporter"
                     /protein_id="HBH0031319.1"
                     /translation="MSDVYYSENHEQDNLYEQDNLLAQRFNLFTLLKFAFPTIFMMIF
                     MGLYTIVDTIFVSRFINTNALSAINIVCPIINLIVGIGTMLATGGSAIVARKMGNGDI
                     EGANKAFSLIVLSGVVIGVIITGIGIVFMDYIIIWLGASEVLIKYCRSYLFIILVFAS
                     ANILQVLFQCLFVTAGKPQFGLWLVLGAGCANIILDYVFIVLLQMGISGAALATGVGY
                     LIPTISGMVFFSKNKGLLKFCIPRLDKRILFEACFNGSSEMVGQLSTAVTTFLFNAMM
                     MKLIGEDGVAAITIIIYSQFLLTSLYIGFSMGVAPIISYNYGSENNTQLNHVFKICIL
                     FISVASLLVFIFSISCSPIIVEIFSQRGSRVYEIARSGFYIFSFSFIFCGYNIFTSSM
                     FTALSNGKVSAILSFLRTFGFITIGLLILPNILNINGIWLAVPSAEILTLFLTVFCIF
                     KYKNRYKYM"
     gene            12017..12730
                     /locus_tag="KR257_002639"
     CDS             12017..12730
                     /locus_tag="KR257_002639"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898517.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HBH0031320.1"
                     /translation="MDTCFNKKILLVDDEKDIVDLIEEVLINDGFKNIIKAYNGLDAI
                     SLCKIACPDVVILDIMLPDIDGIEVCKKIREFSYCSILFLSSKNDDIDKILGLSSGGD
                     DYITKPFSPREIAFRVKAQLRRQQYQSIVPSDSEVIKIGDITIDIEGNRVYKDRNEIE
                     LTGREYHLLSYMAQNVNKIIGKERLYEQVWGVYSSICDNTIMVHIRHIREKIEDNPSN
                     PKILITVKGLGYKLVNRID"
     gene            complement(13002..14540)
                     /locus_tag="KR257_002640"
     CDS             complement(13002..14540)
                     /locus_tag="KR257_002640"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861929.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC-F family ATP-binding cassette
                     domain-containing protein"
                     /protein_id="HBH0031321.1"
                     /translation="MSLLKVTNLSQCFMDKSLYEKANFDLFKGEHIGVVGQNGTGKST
                     LIKILLGEVVPDSGEIKWQPNINIGHLDQYAEINRDTTISLYLHTAFEELYKIEKEMN
                     LLYQKSAISENEQYLIKASDYQEQLIASNFYSIDNEINKIANGLGLDSIGMNRVVREL
                     SGGQRAKVILAKLLLSNHDVLLLDEPTNFLDKEHVEWLSNYLNTFNGAFIVVSHDFDF
                     LEKISTGILDIEFGMIKKYHGKYSEFLKQKSHLREDYIRRYQAQQKKIEKEETFIRKN
                     KAGVNSKIARGRQKQLDKIERIAPPSFTGKPNIQFSEIEISAQNALTITNLEVGYYYS
                     LLPKLNFSVDGGQKIVITGFNGIGKSTLLKTLVKDIPRISGDFQFSEQVKIGYYEQDL
                     KWENPDKTPLQIVADKYPKLNTKEIRRHLARCGVKEEHVSRSVSTLSGGEQSKVKLCC
                     MMLSPCNFLILDEPTNHFDAETKDALQNALKQFRGSIILVSHEEKFYKGWIDKVFNIE
                     KQLV"
     gene            15422..15877
                     /locus_tag="KR257_002641"
     CDS             15422..15877
                     /locus_tag="KR257_002641"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429149.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Lrp/AsnC family transcriptional regulator"
                     /protein_id="HBH0031322.1"
                     /translation="MDEIDLKIINSLKKNSRASTSEISRQINLSVPAVSERIRKIEQS
                     NLIQKYTIQINREKTKYKLLAFIFINTDLSKSMKEFKKTILEYDTVLECHHISGEYDY
                     LIKVLAEDTSNLEEFISVTLKEIGGIQKANTTIVLSTIKEEFNTIKDIF"
     gene            15926..16510
                     /locus_tag="KR257_002642"
     CDS             15926..16510
                     /locus_tag="KR257_002642"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436217.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DJ-1/PfpI family protein"
                     /protein_id="HBH0031323.1"
                     /translation="MKVLVFLAKGFETMEFSVFVDVMGWARNDYGHDIDVVTCGFKKQ
                     VMSTFNIQVLVDKTIEEVCVDDYDALAIPGGFEEFGFYDEAYDSSFLNLIREFNSKEK
                     IIASICVAALPVGKSGVLKNRKATTYHLKNGKRQRQLSEFDVNVVNEPIVVDKNIITS
                     YCPETAPHVAFKLLEMLTSKEQMDEVKLAMGFKL"
     gene            complement(16515..16838)
                     /locus_tag="KR257_002643"
     CDS             complement(16515..16838)
                     /locus_tag="KR257_002643"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891827.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HBH0031324.1"
                     /translation="MKKCLDNYSCPIEATLALIGGKYKTLILWHLKDTILRFNELKKL
                     IPKATPKMLTQQLRELESDGLIIRVVYPVVPPKVEYSLSDFGKSIIPILDSMCDWGSD
                     YLENL"
     gene            16990..17508
                     /locus_tag="KR257_002644"
     CDS             16990..17508
                     /locus_tag="KR257_002644"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429152.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nitroreductase family protein"
                     /protein_id="HBH0031325.1"
                     /translation="MNFVELAKKRYSCRNYQDRKVEKEKLEKVLDVARIAPTGGNRQP
                     QRLIVIQEKEGINKLSKAANIYDAPLAILVCGDKDKVWTRPFDGKQLTDIDTSIVTDH
                     MMLQATELGLASVWVCYFNPDIIREEFSLPDNLEPINILLMGYESKIPESPERHEKTR
                     VPLSEIVSYETL"
     gene            complement(17684..18352)
                     /locus_tag="KR257_002645"
     CDS             complement(17684..18352)
                     /locus_tag="KR257_002645"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891824.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA-binding protein"
                     /protein_id="HBH0031326.1"
                     /translation="MLEVSHKVKEIYPNIKFGVMVINITHSKPNKENFLVLKNSTIKN
                     IIEQHPEYNRKEKIKTEPVSSYIKYYKKFKKTYPVLLQLESILLKSKGIPDVGVTIES
                     MFLAELKNLLLTAGHDLDKMELPLKIELANGSEHFYGIGGKEHILTKDDLFLSDNIGI
                     LSSILNGPDNRTAITKDTKNIMYFVYGPDKISEKQIQDHLNDIKHYISSAFPDLKVNS
                     IDIF"
     gene            18467..19882
                     /locus_tag="KR257_002646"
     CDS             18467..19882
                     /locus_tag="KR257_002646"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729357.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PLP-dependent aminotransferase family protein"
                     /protein_id="HBH0031327.1"
                     /translation="MWITINRNSNISLSRQIYCEIKDMILDGSLKFEQKLPSSRTLSK
                     ELSVSRNTVLDAYNQLIAEGYLETRNGYGTIVAKGISGHKVDFKLNDTFRDEKDLHTN
                     KQKNYIDFRSGVPELKLFPRKELSKLYKQILYDLSDSDFRYGSTAGVWVLRVEISKYL
                     FRTRGIRCNPKNIMIVSGSTQGLSLISQLLYKSNKKVAVEDPIHKGLLKVISSIGYSV
                     VGIKVDDKGMNTNLIKSIKGISFVYTTPSHQYPLGGILPIQRRLELIKCATENDYYII
                     EDDYDSEFRYEGQPISSLYELSPNKVIYIGSFSKILSPAIRVGFMLLPDNILESYKTL
                     KMYSDVHTETILQHVLAEFIGNGGLEKYIFRMKKLYNRKRKYLIKVLNTEFKNEFKIK
                     GEAAGLHIVAHFYNVKFTESLIHKIFEAGIKVYPIQQYAIENILEYDYEIILGYAHLS
                     FDEIEKGVKILSKIIHMNQGT"
     gene            20105..20563
                     /locus_tag="KR257_002647"
     CDS             20105..20563
                     /locus_tag="KR257_002647"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436213.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HBH0031328.1"
                     /translation="MEIIDYIEENLTENLNLDKIAYIANYSKYHLHRMFTNVVGCTIH
                     QYIQRRRLTEAARQLIFTDKYIIDIAITVGYSTHQSFTLAFRNLYKESPQVYRNKDEF
                     YPIQQRFVLNLNHQIQSEKCISYANMNYKQRRDEINSYLNFNINCEVKVA"
     gene            20560..21144
                     /gene="clpP"
                     /locus_tag="KR257_002648"
     CDS             20560..21144
                     /gene="clpP"
                     /locus_tag="KR257_002648"
                     /EC_number="3.4.21.92"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003417022.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-dependent Clp endopeptidase proteolytic
                     subunit ClpP"
                     /protein_id="HBH0031329.1"
                     /translation="MSLVPHVIEQTGQGERSYDIYSKLLKDRIIFIGEEINDAIASLV
                     VAQLLFLESEDPDSDIIIYINSPGGSATSGFAIYDTMNYVRCDVSTICIGMAASMSAF
                     LLAGGTHGKRCALPNSEIMIHQPMGGAKGQATDVKIAVDNILKIKERLDKILSENTGK
                     SIEDIRRDTDRDNFMTALEAKEYGLIDYIMNRNE"
     gene            21456..22532
                     /locus_tag="KR257_002649"
     CDS             21456..22532
                     /locus_tag="KR257_002649"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891817.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase family 2 protein"
                     /protein_id="HBH0031330.1"
                     /translation="MITISLCMIVKNEEEVIGRCLECVKDIVDEIIIVDTGSTDSTKE
                     IVSKYTDMVYDFEWIDDFSAARNFSFSKASKDYTMWLDADDIILEADREKLLKIKESL
                     DTSIDIVMAKYNVSFDENGNPTLSYYRERLFKRSSNHKWVDPIHEVVPLFGEVFYSDI
                     AISHKKLHRQDPLRNLRIFEKMISEGKTLEPRHQFYYSRELYYNARYKEAIEGFTKFL
                     DSSRGWIEDCISACRDLATCYYLINDEKSALYSLFRSFEFDEPRAEICCDIGKHMFDR
                     QKYKEAIFWYKVALTRDKNDTNGGFKSNDCYGYIPSIQLSVCYDRLGESDKAIYYHEK
                     TKEIKPNDSAVLHNENYFSKFKNS"
     gene            22599..>23638
                     /locus_tag="KR257_002650"
     CDS             22599..>23638
                     /locus_tag="KR257_002650"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861926.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="spore surface glycoprotein BclB"
                     /protein_id="HBH0031331.1"
                     /translation="MLLIMSRNKYFGPFDDNDYNNGYDKYDDCNNGRDDYNSCDCHHC
                     CPPSCVGPTGPMGPRGRTGPTGPTGPTGPGVGATGPTGPTGPTGPTGNTGNTGATGLR
                     GPTGATGATGPTGATGAIGFGVTGPTGPTGATGATGADGVTGPTGPTGATGADGITGP
                     TGATGATGFGVTGPTGPTGATGVGVTGATGLIGPTGATGTPGATGPTGAIGATGIGIT
                     GPTGATGATGADGATGVTGPTGATGPTGVGVTGATGATGATGADGATGVTGPTGATGA
                     TGANGLVGPTGATGAAGTPGATGPTGATGPTGVGITGATGATGATGPTGADGATGPTG
                     ATGNTGADGVAGP"
BASE COUNT         8760 a         2808 c         3858 g         8212 t
ORIGIN      
        1 aaattaaaag ttataaaaga ataagttata taaaaaatta ttatattttt taatatagct
       61 tatttgcaaa tttataattt tgttaatcta atccttcaaa ctaaaaaatc atttatattt
      121 acagaatttc attttaagag atgtttattt tcacatagat aagagaattt aagttctcat
      181 atttattatt tgatacaaat ttacatcttt attatatgta ttttaaataa aaaataaaat
      241 tatgaatact agaaatctat cttaattagc tttctaacat aaggctattt aaagtagata
      301 aaactaaaaa gggttctcta gaaaaccaaa tctatttaat tatacttact tactaatacc
      361 atcacttgat gcaaacaaga ttctaccaca ttttctccgt actctagtat aaaatcatct
      421 agttgtgtat ctataaaatc acaataatca tatgaactac caatataagc agtcaacata
      481 tgtgtacatc tatccatttt atctctaaac atatatatta ttatccccct aaaaaacttt
      541 cataaaaaca aaaagaatat ctctttttgg caactggctg acataactca tagtttattt
      601 tataagcgtt agtccctata gctttgcgtc actaaatttc tctagttttg ccgatttagt
      661 tttattctac aattacaata atacaataga attgcttatt attcaatata cttatttgaa
      721 aattaaataa atttacaaat atgaacgtta ttttatatca aaaaaaatag actatgcatg
      781 tagaatatat ggaaaaactt gattgtaggt tttgtatgaa aagacagttg ttattaattt
      841 aagtgagata aattgagcaa caggcataaa atgagaaaac aaataatagc agttaatttt
      901 tattattaat actaggtgaa cattaaattt caaaatacca ctagatttta tagaataaga
      961 aaatgagaca aacataaata tatgaatata ttaaattata cttgaacata cttatatttt
     1021 atgataaaat ttcaataata attattagtg aaggagtgtc ttgcctgatg tcagagttat
     1081 atataatggt aaccaacaaa taaatagttg gagacgcata tgggttctgt ttaatcagag
     1141 tttttaagtg tatttttgat acatttgatt gttgtgtctt actctgcctt tatagataac
     1201 taacattaga caacaaataa taatattaca tattactttg ttaaattgtg gtgtagtggg
     1261 ctttaatctg ctacactttt attaatttta cacagtatta ttttgaatat aattatgttg
     1321 aaatagaaga tactaaattt tctagtccac aggggttttc tgtttttgtg taggtaaata
     1381 tgtataccac ataaaaaggc agatataaat acctgtggac tttttttgta gaaaatacac
     1441 gatacggagg aaataaaaat gaattataaa aatagaaaac gagcttatta tcaggaaaat
     1501 tcctgtatgg ataactttat ttgcaaaaat tgtggttgcc ttgtagttcc tgaaggagct
     1561 ggtacacaac atagaaatca ttgtccacat tgtttacata gtcttcatgt agatatcatt
     1621 cctggtgacc gtgctgcaga ttgtgatgct aatatggaac ctattggagt gtgggtgaga
     1681 aaaaatggtg agtgggcaat tattcatcgt tgtacacgct gtggacatct tagttctaat
     1741 cgtattgcag ctgatgataa ttcagtgaaa ttaatgtcaa ttgcattaaa accactggca
     1801 cagccccctt tcccactaga aagaatcatt gaaaagttgg aaaaggagga aacagaatga
     1861 atggtatgaa acaaatcaat ttacaagact atggtctaaa tagaaatttt attactcaaa
     1921 gtatggaata tcatgattta taccttgctc ggattatctc gcaggaaaag aacttttatc
     1981 aagctgtatg tgtaaatggt gtactgtttg cagaggtttc aggaaagctg cgttttgagg
     2041 ctactataca atctgatttt cccacagttg gtgatttcgt tatgttggat cgttgcaata
     2101 ataaaaatgg taatgctatt attcatcatg tgcttcatag aaaaagcttg tttgtgcgta
     2161 aggctgctgg aaaggtaaat gaggagcagg tggttgcagc taatattgac attgtttttt
     2221 tgtgcatgtc actgaataag gattttaaca ttcatagatt ggagaggtat ctgtctttaa
     2281 catgggaaag tggagctatc ccagtagtag tacttactaa atcagactta tgtgacaatg
     2341 tgcatcgtaa attacaagta gttaattcta tagccttggg tgtagatgta gttgttacct
     2401 catctataga gccagatggt tataaacaga tttctaagta tattaaacca ggctgtactg
     2461 ttgccttact tggttcttca ggagttggaa aatcttcatt aattaattgt ctgatgggtg
     2521 gagaattttt aaatacaaag gaaattcgca tagatgatga taaaggaaga catgccacga
     2581 ctagacgaga gctattttta atttcaggtg gtggtattgt tattgacaca ccaggtatga
     2641 gagagttggg aatgtgggat gtttcagaag gtttagataa aagttttgca gatatagaag
     2701 cttatttcgg aaaatgtcat tttcgtaatt gtactcacac ctcagaacca ggctgtgcta
     2761 tctgggaagc tattgctcat caagaacttt cgcctaaaag atgggaatcc tatcgtaggc
     2821 ttaaaactga agcagtattt gcagacaata aaagcgaata cttagcaaaa aaagaaaaga
     2881 aatttaaaaa tatctcaaaa ataaataaga agattagaag ataagtgtag tttttttgtt
     2941 cattctatga gtctatatac tattaatata ttaaatttgc catcaatttg ttactttaat
     3001 gtgattttga tggcaaattt ggtttgtggt attatttaaa gcaatttatt aattttttta
     3061 ataaagtttg attttttata tgatgatata tacatgtgat aatgtataca tatttgttac
     3121 gataggctcc tttataaaga ggtcttatgt aagataagaa aaggcatatt tatactaata
     3181 cataatagag tatatgctta tgtatgatag agatgtttct taagagcaaa actgcaatat
     3241 tgctaattta taaagtaaaa atatatgaat tataaaatac aaataatata tttataaaaa
     3301 ttattgtttt aatttataat aaaaattttt tgttgaaaat aatgctcgaa cctataaaac
     3361 tattaactaa tatttgtaaa tgtatacttt tgatgataaa atataattaa gttaagttgg
     3421 tttttataaa cataaattta ttttaaggag gtgaaataaa tgaaaatatc tagtcaatat
     3481 agaagtcaat attcatttag atatgaaagt aatataaata atacaagaat aaatgaaagt
     3541 atggttaaga aaaatgaaac tgtaggaaaa gacacttatt tatctaatat tatgaaacaa
     3601 aagcaagaac ttaatgatag aattagagat ttaaaatata gacaagaggt ttatactaaa
     3661 aaaataaatg acgcaattaa gaacttatgt aaatcagaaa taagagaaac aactaataat
     3721 ttttctaata tagaaatagg tattaaaaat agcattatag aagagaaaaa taaaagtaca
     3781 atgttagatg aaaattcaac ttatctaaat acaaatgatg aaaaagaatc tttaatcact
     3841 aaagagtcta atgaaaaaat tgaagaagaa atattaaatg atgaaaaatt agaagagtta
     3901 gaacaaaaaa aggattataa agaggattct aataaaaaag agaaagtatc tgaggactta
     3961 tctttagtag gtaaaactcg tgaagagctt gaaaatatgc ttaaaaattt tataaattta
     4021 acacaagaag aaataatgaa acttgagtcg agaatagaaa agttagataa aaatgctgaa
     4081 gaatacaaac aaaattcaaa gactaatata tttgataaaa cagatgaaca aaaaaaacat
     4141 ataaatgtac tgatttaaac aatatgtttt aaaaaaataa gtttattata taatgaaaat
     4201 ataaaggtac aatttcaata cacttctatt aaaccaataa tttatgaatc agatttaatt
     4261 tcaatttact aataaccata tatttatgag ttaataattt tatgttttaa aaagaattaa
     4321 ataaggggga gtagtatgaa gaagaatata ttaactacta tgattaccat gattattata
     4381 ttgatgatga gtatgacagt aatggcagag ccatatcaag aagatgaaac atctagcttg
     4441 aaaaaacaga gtgcaaatga acgtaatcag actaatatag gcacaatgga tggcagagtg
     4501 caaacaaatg caataagtaa aggtgctaat tatgacccta aatatcctct taaaggaatg
     4561 ttaacacaac ttggtcttaa tacaacaggt aaagagggat gggatttact ctatggagga
     4621 aatcccaatg gagttgagct tcgagcagat ggtaaatatt attatataaa taagggtatg
     4681 gaagggctag gattttatgc ggcagcattg tcaggtggct catatcagag aataggcttt
     4741 ggaaaacttg accctataga agtaatagct gatggaaatt ggatttctta caaacaagct
     4801 caagatacac ttacagtaat caggaatttt ttaaatagct ttgactggag aaatgcatct
     4861 gagatggaaa gagctaatag agctgcaaaa ttggtaaccg aagcaaaata tgcagactct
     4921 aaatattgta acatagtcta tggtaatctg gttgataaac gtggtgtatg tggaagtttt
     4981 gcaagtagct ttcatttatt aacaaggtta atgggaatgg attcactatc tatattaaat
     5041 ccatcattaa atcatgcttg gaactatata caaattgatg ggaaatggta taggtttgat
     5101 gggtctgaaa tatcagcttt tggtggatca ttagactttg attaccgtaa attaaaggat
     5161 gcaacaagag agatgactac ttactatgat gctaaggcat tgtctatatt aggatttaat
     5221 caataaaaat agggggaggc ttcttataga gccttttttt attgatttga aatttaataa
     5281 ggaattttat atgaaaattt aatcaataaa agcaaaaaag gctctttata aagcctttct
     5341 aagtgttttt ttaagtaaaa ttttttatat caacatcagt tttaatcaaa acatataaca
     5401 ttttggactt acttttaaaa ataaaattat taaaatataa tattaatcat gtttttagtt
     5461 tattatattc tataatagtg gtcatgttga ctattgtagt tttattaaga atagttggtt
     5521 tatataaata tatgcaaaga tagcttgttg tttactttac ttattagtat ataggacaag
     5581 atactctaat aaatttgcct attttaatat cttttgtact aaaaccaact aaagtttcct
     5641 ttattatttc gttttgaata atacaaagca taatccgatt gtttgtataa agactggaaa
     5701 gtatcagagt tattttctaa tttagatata cctatagaac aagaattact ctctaggcat
     5761 aattctaaaa ccttctttgc cttattttca acattctctt ttgattgatt actatattca
     5821 aaaacagcaa attcatctcc accaagtctt ccaataatag catcatttac gaatacttta
     5881 gtcaaaatat ttgaaaaatg tattagtatt tcatctcctc gaacatgacc aaagatatca
     5941 tttacctgtt taaaattatc taaatcaaag atgtaaaagt atccatgtga aacagtttta
     6001 agcatttctt ttatgtgtac ttcaaaaaaa tgtctattgt atagtccagt cataaggtct
     6061 ttttctgatt ttagtttaaa ttcatttgcc attgctagtg cttcttgtgc tttttcagtt
     6121 attgttttag ggtaatactc atctttcatt tggtcaaagt ttggaataga atggtgaaca
     6181 tggataagtt taatcatatc atctgtaact ctgtatacca tagtaaatcg agtatccatt
     6241 tctacataga tatctttttc taggtaatct ttttctatta cccaaagagt accatatact
     6301 ataaaagctt cgtctgtaac tttggtacat gaataccact catctataat ctcaaagtct
     6361 atttgctctg attctgtttg gtctttttca agacctataa taaattcttc taatgtttcg
     6421 taaaattcat gttttcctgt tccaattaat gcaaggttgt catctaataa ggaaataata
     6481 aatttaaggt tttcttcttc tggatttaaa atataaatat gccaaatttt ttttgataaa
     6541 tctcttaatt gtttttgtat tgtattattt tccatagatt acccccttaa gatttacagt
     6601 ttatatttta atgtattata agttgaactc ttattacaat attattataa tatagaacta
     6661 aagaaattac atcctgtata agtaaaagta tatcttttat aataaaaata ttacagtaaa
     6721 ataaccagtt ttaatatacg tattatattt ttaatttata aacgaatatt ataaatgaaa
     6781 tttaaattca accctgaaga aataagctaa atgtattagt atataaatcc atacttgaac
     6841 ataaataacc tttatgatat gatatcaata ataatattat gagaggagtg ccttgatgtc
     6901 ggagttatat aatggtaacc aacaattaaa tagttggaga cacatatatt ctgtataatc
     6961 agaaatttca agtgtatttt taatacattt aatttttgtg tcttattctg cctttataga
     7021 taactgacat atgacaacaa atagtattta aaatatatat tactttgtta aattatggtg
     7081 tagtaggctt taatctgcta cacttttatt aattttgtat agtattattt tgataactat
     7141 tttgaaatag agagcattaa tttttctagt ccacaggagt tttctgtttt tgtgctgtta
     7201 aatataagca cagagaaagg cagatatata cctgtggact ttttttatat aaattatgaa
     7261 atatggaggt agttaaaatg agtataattg aacttaatga actgactaaa tcttatagaa
     7321 gatttgagaa aaaggcagga tttatgggga gtgtaaagtc tttatttaat aggaaatata
     7381 cagaaaaaac agctatatcg tcatttgatt taaagataga agaaggagaa tttgttggat
     7441 taataggtca aaatggagct ggcaaaacta ctcttattaa gatgttaact ggtattattg
     7501 caccgtcttc tggagaaata tctgtaatgg gttattaccc taacaaatta gaaaataatt
     7561 ttaaaaaaca atatgctgtt gttatgggcc aaaaaagtca actattcttt gaattgacac
     7621 cagcagatac gtttctttta tttaaagaat tatatgatat atctaatgaa gaatataaga
     7681 aaaacttgga ttactttatc gaattatttg aggtatctga ctatttaaat gttcaagtta
     7741 ggacgctttc tttaggagaa agaatgaaaa tggaactaat agtagccctt ctacataatc
     7801 caaaaatatt atttttggat gaaccaacta taggcttaga tgctatagcc caaaaacaaa
     7861 ttaggtattt cctaaaagaa gtaaatgaaa caaaaggaac tactattata cttacttctc
     7921 attacatgga agatattaag agtctctgta gtagaagtat tgttgtagaa aatagccgta
     7981 aaatatatga tggttctaca gagaaactat ttaattattt tcaaaaatat aaaaaaataa
     8041 cagttagttt ttccaatgaa actaacattg tatttccaaa agattgtaaa gttgttgaac
     8101 aaacaaatca taagatatca gtaattgtgc caaaagaaag aggaaatgaa acgattaaat
     8161 ggatttttga taaatatgat gttaaagatg taatgattga agaagaagat ataggtagta
     8221 ttgtagagag gatatataag aaaggaagtg atgagtatta tgagcaacta taatgaagca
     8281 agttcaaatg attcaatgtt ttataaattt aaacagagta ttagaaggta ttatgaagta
     8341 gccaaaatta actttaaagt gcaacttatc tggagatttg atgtggtggt taatatggtg
     8401 tttacgattg taaaaatttt atttgcttat attttatgga aagcaatttt tggtgaaaat
     8461 aaaatagtct ctggttttac atttaactct atgttatctt actatataat aagctcattt
     8521 ttagcaggta ttgatatgtc aaagagtacc agtgaagaga tatgtaatcg tgtaaaattg
     8581 ggcacctttt caaagtacat gattattcca attaatgttc aaaattattt tattgctaaa
     8641 aattttggaa tgacatgttt ttattttgta tttaatatga tttctgcatt tgtatggatt
     8701 tttatattta aaatagattt tgcctttaca tcaaatccag ttcaaatatt aatttcaatt
     8761 ttgatgattt ttctagggtt tatttttatg atgaaactcc acttctttat tgggattttg
     8821 tcatttaaat ttcttgagat tagtttttta aaaatgataa ttgaaaatat tgttgaattt
     8881 attacaggaa caatgatacc acttgtactc ttaccagaaa ctatagtaac agttatgaag
     8941 gtatttccat tttattatac aacatatttg ccatctatgt tactaatagg tagaaacagc
     9001 aatgaggcaa tacaaggatt aattattcta gcattatggg ttttattttt ttctgtagta
     9061 aataaagtta tgtataaaag aatgagaaca ttatttgatg gggtgggtat atgatgaaaa
     9121 aaaatttgaa aataatattt atgttattaa aaatgaaatt atcaaagatg atggtattta
     9181 gattcgattt ttttggagca ttttttgtag atagttcatt atttatatta caacttctaa
     9241 tgtttaatag tatatattct catgtagact caataggggg atggcaacaa ggagagatgt
     9301 taatatttat aggaactttc tcattaataa atgcgataaa tatgacgatt ttcttttttg
     9361 gtatttatga tattccacga aaaatccaag aaggagaatt agactactat attacaaaac
     9421 cattagaccc actatttagg ttaacatttg aaaatattaa tattggttca tcaccattaa
     9481 ttctagcaag tatacttatt gttttatatg gaatatctga gttaaactca gagataactt
     9541 tagttatgat aataatatat attttcatgg tgttattgat gacattactt ttttatgatg
     9601 tatgtatcat acttagaaca gtttcatttt ttgttatatc atcttctgcg ataatgagat
     9661 tagaagataa tttattgcca atgaatatga aaattcctgg tgtaatatat gaaggtattt
     9721 ttaaagtatt attctattta atcttaccat atggaattat gtcgacaatt ccgactcaaa
     9781 ttttggctgg gacaataaca attaatggat taatatactc aattttaatt gtatttttgt
     9841 ttacattgtt tatgtggaga ttttggaagt taggtatgag acattataaa agtgcaagta
     9901 gttaataaat tagtaaaaat agacaatgta taactatata taaatacgtt tcatatgaca
     9961 ctaaactatg tgaacaagta tttgcgctaa aggcactgaa agctataaaa tgattaaagt
    10021 aaggatttaa aagtttcttt agtagaaata taattgtgta aaaaagcaag attaattaaa
    10081 actatatcca aataattaga tataattctt atgcagaaag gaggtctgta aatgtctaat
    10141 tgtttggaat atattttaaa aataattaat gtacagaaaa ataaacaaaa tgagtgatgt
    10201 atattattca gaaaatcatg aacaagataa tctttatgag caagataatt tactggcaca
    10261 aagatttaat ttatttactc tattgaagtt tgcatttcct actattttta tgatgatttt
    10321 tatggggttg tatacaatcg tagatactat atttgtatca agatttatta atacaaatgc
    10381 tctatcagca attaatattg tatgtccaat tattaatctt atagttggaa ttggaactat
    10441 gcttgccact ggaggaagtg ctattgtagc acgtaagatg ggaaatggtg atattgaggg
    10501 agcaaataaa gctttttctt taatcgtatt atcaggagtt gtaattgggg taataattac
    10561 tggtataggt attgtattta tggattatat cattatatgg ttaggagcaa gtgaagtttt
    10621 aattaaatat tgtcgttcat atctttttat tatcttggtt tttgcttctg caaatatact
    10681 acaagtatta tttcaatgtt tatttgtaac agctggaaag cctcaatttg gattatggct
    10741 agtgttaggt gctgggtgtg ctaatataat tcttgactat gtgttcattg ttctgttaca
    10801 aatgggtatt agtggagcag cacttgcaac tggagtagga tacctaattc ctaccatttc
    10861 aggtatggtt ttcttttcaa aaaataaagg gttacttaaa ttttgtatac ctagactaga
    10921 taaaagaata ttatttgaag cttgttttaa tggttcatct gaaatggtgg gtcaactatc
    10981 aacagcagtt actacttttt tatttaatgc tatgatgatg aaattaattg gtgaagatgg
    11041 ggttgcagct attacaataa ttatttattc tcaatttctt ttaacttcgc tttatatagg
    11101 tttctcaatg ggtgttgcac caataataag ttataactat ggaagtgaaa ataatacgca
    11161 gttaaatcat gtttttaaga tttgtatatt atttatttca gtagcatctt tattggtatt
    11221 tatcttttct atatcatgtt caccaatcat tgtagagatt ttttctcaaa gaggaagccg
    11281 agtttatgaa attgcaaggt ccggatttta tatattttct tttagtttta ttttttgtgg
    11341 atataatatt tttacctcat ctatgtttac agcattatca aatggaaagg tgtctgcaat
    11401 attatctttt ctacgtacat ttggatttat aactataggt ttattgatat tgccaaatat
    11461 attaaatata aatgggatat ggttagcagt accaagtgct gagattttaa ccttattttt
    11521 aactgttttt tgtatattta agtataagaa tagatataaa tatatgtaga tattaaataa
    11581 atagcttaga tagatatttt atgttttaat aagtaattca attagtggta gatatatact
    11641 attgaaaatt aaagttataa ttgatataaa gaattaataa aaataacata taaaagttta
    11701 aaagggagtt gaacttaaag tttgattaga aaaagtcaat tttaagacaa ctccttttat
    11761 tttactattg tattaatctg tatctgtaag tgtattagtc taatattata aactttggat
    11821 gaaattaatt ttctataggt tttaatgtat catacacttt attttaaaga aacttatctt
    11881 aattttcata gtgattgaat ttgtctatta gagatgttac tattagtaat gtaaaagcaa
    11941 gagtagtgaa tataaaaaac aagatagtga tactgcaaga ttagaatata ataaattttt
    12001 atggagagat ttcaatatgg atacatgttt taataaaaaa atattacttg ttgatgatga
    12061 aaaggatata gtagatttaa ttgaagaagt actcataaat gatggtttta aaaacattat
    12121 taaagcttat aatggtctag atgctatttc gctgtgtaag atagcatgtc cagatgttgt
    12181 cattcttgat ataatgttac cagatataga tggtatagaa gtgtgtaaaa aaattcgaga
    12241 gttttcatac tgttctattc tttttttatc atcaaaaaat gatgatattg acaaaatact
    12301 aggtcttagt agtgggggag atgactatat aacaaagcca ttcagtccaa gagaaattgc
    12361 ttttcgagtt aaagcgcaat tacgtagaca acagtatcaa agcattgtac catcagatag
    12421 tgaagttatt aaaataggag atattactat tgatatagaa ggaaaccgtg tatataaaga
    12481 tagaaatgag attgagttaa ctggaaggga gtatcatctt ttaagctaca tggctcaaaa
    12541 tgtaaataaa attataggaa aagaaagact ctatgaacaa gtatggggag tatatagtag
    12601 tatttgtgac aatacaatta tggtgcatat acgacatata agagaaaaaa ttgaagataa
    12661 cccctcaaat cctaaaatac ttataacagt taaaggacta ggatataaac ttgtgaatag
    12721 aatcgattag aatagatttt aatattaatg aagatatctc aagttgaatt tttagttaat
    12781 gaggcattct tttatgggtg aaatcaaatg tattttcgtt atctcaacaa tgaagaagag
    12841 gtctatctct attttgagat agcctcatta agtttatatc ctggtaatgt actttatgtt
    12901 ctaataaaat ttttttagtt tatttgcagt gaaacattaa ctagaacatt aaaatttgca
    12961 ttgaaatacc aattaaataa tattgtatat tgtgtataaa cttatactaa ttgtttttct
    13021 atattaaata ctttatcaat ccaaccttta taaaattttt cttcatggga aactaggatt
    13081 atacttcctc taaactgttt caaagcattt tgtaaagcat cctttgtctc tgcatcaaag
    13141 tgattggttg gttcatccag aataagaaaa ttacaaggag ataacatcat acaacataat
    13201 ttaaccttag attgttcacc accacttaaa gtagatacac tccttgaaac atgctcttcc
    13261 ttcacaccac atctggctag atgacgtcta atctcttttg tatttaattt tggatattta
    13321 tctgctacta tttgaagtgg ggttttatca ggattttccc attttaaatc ttgctcataa
    13381 taaccaattt taacttgttc tgaaaactgg aaatctccag atatacgagg aatatctttg
    13441 actaatgtct ttaacaaggt agatttaccg attccattaa aaccagttat aactattttt
    13501 tgacctccat caacagagaa atttaatttt ggaagtaaag aatagtagta tccaacttca
    13561 agatttgtta tagtaagagc attttgagcc gatatttcaa tttctgaaaa ttgaatattt
    13621 ggttttcctg taaaactagg aggagctatt ctttctattt tatccaattg tttttgtctt
    13681 cctcttgcaa tttttgaatt tactccagct ttatttttac gtataaatgt ttcttctttt
    13741 tctattttct tttgttgtgc ttgatacctt ctaatataat cttctcttaa atgtgatttt
    13801 tgtttaagga actctgaata ttttccatga tatttcttaa tcatgccaaa ttctatatca
    13861 agaatacctg tagaaatttt ttctaaaaag tcaaaatcgt gggaaactac aataaatgcc
    13921 ccattaaatg tatttaaata atttgagagc cattcaacat gctctttatc taaaaagttt
    13981 gttggttcgt ctaataatag aacatcatgg ttagaaagta gtaattttgc taaaattacc
    14041 tttgcccttt gaccaccact aagctctcta acaacacgat tcattcctat tgaatctaat
    14101 ccaagaccat ttgctatttt atttatttca ttatctatag aatagaaatt acttgctatt
    14161 agttgttcct gataatctga tgctttgatt agatattgct cattttcaga tatagcactt
    14221 ttttgataga gtaaattcat ttccttttct attttataaa gttcttcaaa tgcagtgtgt
    14281 aaatagagtg atattgttgt atctctattg atttctgcat attggtctaa atggcctata
    14341 ttgatattag gttgccactt gatttctcct gaatctggaa caacttctcc caataaaatt
    14401 ttaattaatg tacttttacc tgtaccattt tggccaacta cacctatatg ttcacctttg
    14461 aataaatcaa agttagcttt ctcatacagt gatttatcca taaaacattg tgataaatta
    14521 gttactttta ataaactcat aattcaaact ccttttcttt tattaaaaaa tttatggaaa
    14581 taaaaaaagc agaggaatgg cattgtaaaa tgccgacctc tgcttttgga aaaacaaaag
    14641 gtcatagaca agcattgttg tctatgacca gaaaatctat attatctatc ggcaaatagg
    14701 taattttaaa taagcatagc caaaaaacta tactaaacct atatttgccg atgaagatag
    14761 aaagctttaa gctttcagat taacctctac acaacgcttc atcgtataca tttgtgtaga
    14821 gttaagtttt ctaacaagtt taactaattc tatataaatc ataattattc acatcctaat
    14881 cttagtatta attctagttt atctgtattt aaattgtact tttgtacttt gtggattatc
    14941 ttatttattt aaaatatgtt ttattaatta tagcttaagt tatgttatca taatacttag
    15001 ttatagtcaa taagaaagtt atatttacta ttattatatt aatttagtaa atctatcatt
    15061 acaaagttat ttgaagactc gctatcaata aaattttata gtctataaga aaattaagat
    15121 tatgagtttt ataattttga tatagggata ctattttcat aaatattaca acatgtagaa
    15181 gtatatgtct attattgttg aattttcaat gatatattaa ggttctaata tattatacaa
    15241 aataaaaaca ttaattcaac ttaaataatt ttaagtatta tatgtgtttt gattaaagaa
    15301 aactaaaatt ttaaggaaaa ataacatatt tgtattaaat tttattgaaa tgattaaatt
    15361 tatttactta atgtaaatta ttagctaaaa ttgtattaaa taattaagga ggtgagtagc
    15421 tctggatgaa atagatttaa aaataattaa ttctctaaaa aagaatagta gggcttcaac
    15481 ctctgaaata agcagacaaa ttaatttatc agtaccagca gtctcagagc gtataaggaa
    15541 aattgagcag tcaaatttaa ttcaaaagta cactattcaa attaatcggg aaaaaacaaa
    15601 atataagctt ttggctttta tatttatcaa tactgattta tctaaaagta tgaaagaatt
    15661 taagaaaact atattggaat atgatactgt attagaatgt catcatattt caggagagta
    15721 tgattactta ataaaagtat tagcagaaga tacaagtaat cttgaagagt ttatatcagt
    15781 gactttgaag gaaattgggg ggattcaaaa agctaataca accattgttt tatctacaat
    15841 taaagaagaa tttaatacaa taaaagatat tttttaaata atttactagt aaagtgttaa
    15901 ttatatttta ggaggaaaat agaatatgaa agttttagtt tttttagcaa aaggttttga
    15961 aactatggaa tttagtgtat ttgtagatgt tatgggatgg gctcgtaacg attatgggca
    16021 tgatattgat gtagtgactt gtggatttaa aaaacaagtt atgagcacat ttaatataca
    16081 agtattagtt gataagacga tagaagaagt atgtgttgat gattatgatg ctctagctat
    16141 tcctggagga tttgaagaat ttggatttta tgatgaagca tatgattcat cttttttaaa
    16201 tctaataagg gagtttaatt caaaagaaaa aataatcgct tctatttgtg tggcagcatt
    16261 gccagttgga aaaagtggtg ttttaaaaaa tcgtaaagct actacatatc atttgaaaaa
    16321 tggtaaaaga caaagacagt taagtgagtt tgatgtaaat gtagttaatg aaccaattgt
    16381 tgtagataaa aatattataa cctcatattg tccagaaaca gctccacatg tagcttttaa
    16441 gcttttagaa atgttgacat ctaaagaaca aatggatgaa gttaaattag caatgggatt
    16501 taaactgtaa tggtttatag attttctaag taatcagaac cccagtcaca catggaatct
    16561 aaaattggaa taatactctt tccaaaatca gatagcgagt attctacttt tggaggaaca
    16621 acaggataaa ccactcttat aattaaacca tctgattcta attcacgtaa ttgttgagtt
    16681 aacatcttag gcgttgcttt aggaattaat ttttttaatt cattgaacct caatatagtg
    16741 tctttaagat gccaaagtat aagtgtctta tatttaccac caatcaatgc aagtgttgct
    16801 tctattgggc aactgtaatt atctaaacat tttttcattt ttgggctcct ttatttattt
    16861 taaagtatct ttttaggtac tatattacaa aaaagtgcat tattgtaata tagtaccata
    16921 gtgataaaat tatagcatag gttaaataaa tcatcaactt agcctaataa aacaataggg
    16981 ggtaaataaa tgaatttcgt tgaacttgca aaaaaaagat attcttgccg taattatcaa
    17041 gatagaaagg ttgaaaaaga aaaacttgag aaggttttag atgttgcaag aatagctcca
    17101 actggtggta atcgtcaacc tcaaagattg attgttattc aggaaaaaga aggtataaat
    17161 aaactttcta aggctgccaa tatatatgat gcgccattag caattcttgt atgtggagat
    17221 aaagacaaag tttggacaag accttttgat gggaaacaac ttacagatat tgacacaagt
    17281 atagttacag accatatgat gttacaggca actgaacttg gattggcaag tgtttgggtg
    17341 tgctatttta atccagatat aattagagaa gagtttagtt tgccagataa tctagaacca
    17401 ataaatatat tattgatggg atatgaatct aagataccag agagcccaga gagacatgaa
    17461 aaaactcgtg ttcctttaag tgaaattgtt tcttatgaaa ctctttaatt ataaaattaa
    17521 gttattcata ggataaatgt aataaagtgt ttgttataaa caaaattcaa aataaataat
    17581 atctacatat aattaatttt agtgaagtat atctagttta actagaatgt atacttcact
    17641 aatttattta ttcaaaatat ttatgaggat tttaatatat taactaaaat atatcaattg
    17701 aattaacttt taaatctgga aaagcacttg aaatatagtg ttttatatca tttaaatggt
    17761 cttgaatttg cttttctgat attttatcag gtccatatac aaaatacata atatttttag
    17821 tatcttttgt tatagctgtt cgattatcag ggccattaag aatactagat aatataccaa
    17881 tattatctga taaaaataaa tcatcttttg ttaaaatatg ttctttacca cctataccat
    17941 aaaaatgttc acttccattt gctaattcta ttttcaaagg taattccatt ttatcaaggt
    18001 catgacctgc tgttagaaga agatttttca attctgctaa aaacattgac tcaattgtta
    18061 cacctacatc tgggatacct tttgatttta atagaataga ttctaattga agcaatacag
    18121 ggtaagtttt cttgaatttt ttataatact ttatataact tgaaacaggc tctgttttaa
    18181 ttttttcttt gcgattgtat tctgggtgtt gttctataat atttttaatt gtagagtttt
    18241 taagaactaa aaaattttct ttattaggtt ttgaatgtgt aatatttata accataactc
    18301 caaatttaat attgggataa atttctttaa ctttatgtga tacctctaac ataatataga
    18361 ctccttttta ttttatattt tatgatataa tcttagcaaa ttaaaagtgg attttatagt
    18421 tccattttta tagtaatttt atagaaccac ttttggaggt attagaatgt ggattacgat
    18481 taatagaaat agtaatatat cattatcaag acaaatttat tgtgagataa aagatatgat
    18541 tctggatgga agcttaaagt ttgagcaaaa actgccatca tctaggactt tatcaaaaga
    18601 actatctgta tctcgtaata cagttttaga tgcatataat caattaattg cagaaggata
    18661 tttggaaaca aggaatggat atggaacaat tgtagctaaa ggaatatcag ggcataaagt
    18721 tgattttaag ttaaatgata cttttagaga tgaaaaagat ttacatacta ataaacaaaa
    18781 aaattatata gattttcgtt caggagttcc agaattaaaa ctatttccac gcaaagaact
    18841 ttcaaagcta tataaacaaa tactgtatga tttatcagat tcggatttca gatatggaag
    18901 tacagctggt gtatgggttt taagagtgga aatatctaag tatttatttc gtactagagg
    18961 aattagatgt aatcccaaaa acattatgat tgtttctggt tcaacacaag gtttatcttt
    19021 aatttcacag cttttataca aaagtaataa aaaggttgct gtagaagacc ctattcataa
    19081 aggcttatta aaggttattt catctattgg atattcagtt gttggaatta aagtagatga
    19141 taagggaatg aataccaact taataaaatc aataaagggg atttcttttg tttatactac
    19201 accttctcat caatacccat taggagggat tttacctatt caaagaagac tagagcttat
    19261 taaatgtgca acagagaatg attactatat aattgaagat gattatgata gtgaatttag
    19321 atatgagggt caaccaatta gttctcttta tgaacttagc ccaaataaag taatttacat
    19381 aggttctttt agtaaaatat tatctccagc tattcgtgtt ggatttatgt tattaccaga
    19441 caatatttta gaaagctata aaaccttaaa aatgtactct gatgttcata cagaaacaat
    19501 attgcaacat gtattagctg aatttattgg aaatggaggt ttagagaagt acatatttag
    19561 aatgaagaag ttgtacaata gaaaacgtaa gtacctcata aaagttttaa acacggaatt
    19621 taaaaatgaa tttaaaataa aaggtgaagc agcagggctt catatagttg ctcatttcta
    19681 taatgttaaa tttacggaaa gtttaattca taaaattttt gaagcaggta taaaagttta
    19741 tcctatacaa caatatgcaa ttgagaatat attagaatat gactatgaaa ttatactagg
    19801 ttatgctcat cttagttttg atgaaattga aaaaggtgta aaaatactca gcaaaataat
    19861 acatatgaat caaggtacat agataaaaca tgtagcaatc tacatataat agatgtaatt
    19921 aagtttaaac tttaaaagaa atatatatta atatttttgt ataaaaatac ctgatatttt
    19981 tttatcgata ctttattgct atacactaaa ttaagatagc aatttatatt aagaaaaaac
    20041 tttttgcata ggttataata cttaaaagga gaggatagag ttgaaaacaa atacagatgt
    20101 tattatggag ataattgatt atatagaaga aaatcttaca gaaaatctaa atttagataa
    20161 aatagcttat attgctaatt attcaaaata ccatttacac agaatgttta caaatgttgt
    20221 aggatgtact atccatcaat acatacagag gaggagactt actgaagcag ctagacaact
    20281 tatatttaca gacaaatata ttatagacat agctattaca gtaggatatt ctacacatca
    20341 atcttttaca ctagcattta gaaatttata taaagaatct ccacaagtat atagaaataa
    20401 agatgaattt tatcctattc aacagagatt tgttttaaat ctaaatcatc aaattcaaag
    20461 tgaaaaatgt atttcttatg caaatatgaa ttataaacaa agaagagatg aaatcaattc
    20521 ttatcttaac tttaatatta attgtgaggt gaaagtagca tgagtttagt gccacatgta
    20581 attgaacaaa caggtcaagg ggaaaggtct tatgatatat attcaaaatt attaaaagat
    20641 agaattatat ttataggaga agaaattaat gatgctattg caagtttagt agtagctcaa
    20701 ttactgtttt tagaatcaga agacccagat tcagatataa ttatatatat aaatagccct
    20761 ggtggctctg ctacatcagg atttgctata tatgatacta tgaattatgt cagatgtgat
    20821 gtatcgacta tttgtattgg tatggctgca agcatgagtg cttttttact tgcaggagga
    20881 acacatggaa aaagatgtgc tttacctaat tcagagatta tgattcatca gccaatggga
    20941 ggagctaaag gtcaagcaac agatgtaaaa atagctgtag ataatatatt gaaaataaaa
    21001 gaacgattag ataaaattct ttctgaaaat acaggtaaat caatagaaga tattaggaga
    21061 gatacagata gagataattt tatgactgca ctagaggcta aagagtacgg gctgattgat
    21121 tatataatga ataggaatga ataaagtatc aaagtatcat attaaaatgt ctgttttaca
    21181 aatatatata taatattaaa taagagtgtc tcaaaatgaa ctttttagtt tatgggacac
    21241 tcttttttgt atgaaattaa atatggtttt atcatttcaa caattattac caaatttcaa
    21301 gtttaataaa ttctactata aaaaatacat aaaagataag gttctttagt aactttctgt
    21361 cgtcaaaagt ttttataaat ttaataacaa aacaagagaa aataccatat attacttatg
    21421 tctgcaatat atagaagaca aaggagttgt acattatgat tacaataagt ttgtgcatga
    21481 ttgttaagaa tgaggaagaa gttataggca gatgcttaga atgtgtaaag gatatagtag
    21541 acgaaattat aattgtagat acaggttcta cagattccac aaaagaaata gtctcaaaat
    21601 atacagacat ggtgtacgat ttcgaatgga tagatgattt ctctgctgca agaaattttt
    21661 cattttctaa agcttctaaa gactatacta tgtggcttga tgcagatgac ataattttag
    21721 aagctgatag agaaaaatta ttaaagatta aagaaagctt ggatacttcc attgatattg
    21781 ttatggcaaa atacaatgta tcctttgatg aaaatggtaa cccaactctc tcgtattata
    21841 gagaacgatt gtttaaaaga agttctaatc ataaatgggt tgaccctatt catgaagtag
    21901 tacctctttt tggagaggta ttttattctg acattgcaat atctcataaa aagcttcata
    21961 gacaggaccc tctaagaaat cttagaattt ttgaaaaaat gatttcagaa ggaaaaacat
    22021 tggagccaag acaccaattc tattattcta gagagttgta ctataatgct aggtataaag
    22081 aagcaataga aggttttact aagtttttag actcatcaag aggatggatt gaggattgta
    22141 tcagtgcttg cagagattta gccacatgtt attacttaat taatgatgaa aaaagtgcct
    22201 tatattcatt gtttagaagt ttcgaatttg atgagccaag agcagaaatt tgttgtgaca
    22261 taggaaagca tatgtttgat agacaaaaat ataaagaagc cattttttgg tataaggtag
    22321 cattaacaag agataagaat gatactaatg gaggttttaa gtcaaatgat tgttatggat
    22381 atataccatc tatacaatta agtgtctgtt atgacaggtt aggagaatca gataaagcta
    22441 tttattatca tgaaaaaaca aaagaaatca aacctaacga tagtgctgtt ttgcacaatg
    22501 aaaattattt tagtaaattt aaaaatagtt gataggtcac aatcatacta aatttgacat
    22561 attatatata gagcttaaaa gctcaaatat atcaggaggt gcttttaata atgagtagaa
    22621 ataaatattt tggaccattt gatgataatg attacaacaa tggctatgat aaatatgatg
    22681 attgtaacaa tggtcgtgat gattataata gctgtgattg ccatcattgc tgtccaccat
    22741 catgtgtagg tccaacaggc ccaatgggtc caagaggtag aaccggccca acaggtccaa
    22801 cgggtccaac aggtccagga gtaggggcaa caggcccaac aggaccaacc ggtccgactg
    22861 gtccaacagg aaatacaggg aatacaggag caacaggatt aagaggtcca acaggagcaa
    22921 caggggcaac aggcccaaca ggagcgacag gagctatagg gtttggagta acaggtccaa
    22981 caggcccaac aggagcgaca ggagcaacag gagcagatgg agtaacaggt ccaacaggtc
    23041 caacgggagc aacaggagca gatggaataa caggtccaac aggagcaaca ggggcaacag
    23101 gatttggagt aacaggtcca acaggcccaa caggagcaac aggagtagga gtaacaggag
    23161 caacaggatt aataggtcca acaggagcga caggaacacc tggagcaaca ggtccaacag
    23221 gggcaatagg agcaacagga ataggaataa caggtccaac aggagcaaca ggagcaacag
    23281 gggcagatgg agcaacagga gtaacaggcc caacaggagc aacaggccca acaggagtag
    23341 gagtaacagg agcaacagga gcaacagggg caacaggagc agacggagca acaggagtaa
    23401 caggtccaac aggagcaaca ggggcaacag gagcaaatgg attagtaggc ccaacaggag
    23461 ccacaggagc agcaggaaca cctggagcaa caggtccaac aggagcaaca ggcccaacag
    23521 gagtaggaat aacaggagca acaggggcaa caggagcgac aggtccaaca ggagcagatg
    23581 gagcaacagg tccaacagga gcaacaggaa atacaggagc agatggagta gcaggtcc
//
LOCUS       DAEPID010000060        23567 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.060, whole genome shotgun sequence.
ACCESSION   DAEPID010000060 DAEPID010000000
VERSION     DAEPID010000060.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 23567)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 23567)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..23567
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.060"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            <1..973
                     /gene="mltG"
                     /locus_tag="KR257_002651"
     CDS             <1..973
                     /gene="mltG"
                     /locus_tag="KR257_002651"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419238.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=2
                     /transl_table=11
                     /product="endolytic transglycosylase MltG"
                     /protein_id="HBH0031332.1"
                     /translation="NKKDVIIDVPSGASVGKISDILYENKLIKNELLFKLLVKVSNKA
                     PSIKSGTYLLNQSYSNNDIISLLVSGKIYQDGIKVTIPEGATSKEIIAMLVSKNLGDK
                     ATFENLIKKPQEFYDKFPYLKEDGITSLEGFLYPETYYFNSKKQSEEDILSEMLKVFD
                     SKYTDKFKKKQKELNMTLQEVMEMASIIEKEAVLDKDRPIIASVFYNRLKVGMPLQSD
                     ATIQYIFEERKKIVTYDDLKIDSPYNSYKNKGLPPTPISNPGIKSIEAALYPEKTDYL
                     YFVAKIDGGNNYSTNYQDHLKYVKEYKEARDKQSKDTKATNKENTKK"
     gene            1145..1819
                     /locus_tag="KR257_002652"
     CDS             1145..1819
                     /locus_tag="KR257_002652"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419240.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="O-methyltransferase"
                     /protein_id="HBH0031333.1"
                     /translation="MSNIVNDLVEDYIRVTLKEKEGFLKDLEIYAEENSVPIIHKEVS
                     DLLKVLLKVQKPKRILEVGCAIGYSSIFFATIIGKDADIITVERNEKMIEKAKENIKL
                     AGFDNNITILEGDAEEKLSQVQGEFDLIFIDAAKGQYKLFFDLVIDKLKDGGLLVSDN
                     ILYKGMVAHDDFVVRRKKTIVKRMRNYLDYICNCDYLSTSLVPIGDGVALSYKESKRG
                     DVDGIK"
     gene            1806..3053
                     /locus_tag="KR257_002653"
     CDS             1806..3053
                     /locus_tag="KR257_002653"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438167.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="U32 family peptidase"
                     /protein_id="HBH0031334.1"
                     /translation="MELNKVELLAPAGDLERLKIAITYGADAVYIGGEIFGMRSAAKN
                     FSKEDMAEGVAFAHERGKKVFVTVNIIPHNEDFLQLEDYLLELEEIGIDAVIIADPGV
                     LSVIKKVIPNMEIHLSTQANTTNYLSANFWYEHGIKRVVVARELSFDEISEIRAKTPL
                     DMDIEAFMHGAMCISYSGRCLISNYMTGRDANKGSCAQSCRWQYHLVEEKRPGEYFPI
                     YEDERGTFFFNSKDLCMIEYIPELIKSGITSLKIEGRMKTAYYVATVVRAYRMAIDEF
                     YRDPENWKFNPMWMEELKKGSHRHFTSGFYLNKPTTEDQNYQSASYVRNYDFIGIVRE
                     TEDEDGLIVVEQRNKMCVGDEIEVMGPYKETMFTKIEEMYNEEGEAIESAPHPRQIVK
                     LKLSVKVGKDYMLRKVIEEKVEE"
     gene            3125..4789
                     /locus_tag="KR257_002654"
     CDS             3125..4789
                     /locus_tag="KR257_002654"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896136.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="penicillin-binding protein 2"
                     /protein_id="HBH0031335.1"
                     /translation="MSKKKTPFLKKVGKRSWCIFTIILIIYSVLIYRLVDIQVLKGDK
                     YKQSVESQSVEKVELNSGRGIIYDRNNKKLTDTSKSQVLIVEKEKLNNNYKILELIKK
                     ATKMNDLDIYKAVQEQLTRPIIQIQTKNIDKSMKKELEKNGIMVEEKTMRYAKDGLLS
                     HTIGYIKEDDKSGQSGIEKSMDSVLRNSNEKYISAFKAGDAGNEKSLNILKGSVKTVD
                     NKDKDRHLKTTIDYNIQKKLEQILNKEENPTAAIISEASTGEILAMCSRPNFDQNDIS
                     KSLKGKNGEFENRVIKATYPPGSVFKMVVLFSALENGVIDENYTYNCTGKTKVGNTNE
                     ILRCNKRDGHGFQNLRQAFSNSCNPAFLDIAMKLGKEKILKSAEKLHLFEKVDIGLDE
                     EKIREAPKNISIRNLAIGQENIEFTPLQINQMTQIIANNGTFKPLYLYKSLVDNNMNT
                     IKTYKSSKKEELISPYVCTQVKEYMKSVSRIGTAKDLKDIEGGCGVKTGTAQSSLNKK
                     AIDHGWITGFYPEERPKYVITVLVEGTQKGNKSATPIFKEICESIK"
     gene            complement(4886..5527)
                     /gene="sigK"
                     /locus_tag="KR257_002655"
     CDS             complement(4886..5527)
                     /gene="sigK"
                     /locus_tag="KR257_002655"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018589741.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RNA polymerase sporulation sigma factor SigK"
                     /protein_id="HBH0031336.1"
                     /translation="MAALKSFEKPLTPEEEIEYLTKFKIENDKSAKDTLIERNMRLVA
                     YIAKKYNNSTEDQDDLISIGTIGLIKAIETYNIDKGTRLATYASRCIENEILMNIRSN
                     KKNKTQVSLQDPIGTDKEGNEISLLDILGTEANYVLDEVELKVQVGKLYEQLNKILTP
                     REREIVQLRYGLTPYGYKTQREIAQKLDISRSYVSRIEKKALKKLEKELVQES"
     gene            6094..6456
                     /locus_tag="KR257_002656"
     CDS             6094..6456
                     /locus_tag="KR257_002656"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009905375.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0031337.1"
                     /translation="MKIRKSGFISIECIISIAILYVAVYLVSTSLYNCYSFISRNISD
                     REMLSTAKKYIEDEKYRIQNSKYELIEDKIEKNYINGYEINSRIEQILDYYQCYEINI
                     EIKNEFKKLRFNSYVTRK"
     gene            6440..7147
                     /locus_tag="KR257_002657"
     CDS             6440..7147
                     /locus_tag="KR257_002657"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018112787.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0031338.1"
                     /translation="MLLENKGSILIITLIIFSIISTVCIMCIGLIYTHNNMFELGYKD
                     IQLKEISLSGIEISVSNVLSCVEEAIDISNNEDEFREYFLGNNMIECIKKIKDTSYSS
                     LEELSLKVENNTIYDRGDFFEFDIESNVREKEFLKAIKVRVKIKNPWIGIDIEDYMDK
                     SNNNKIDDKTFNNYKASENNEIINQFKNESENIRNQEVVEFTEEDEEELKQNIIENIK
                     KNFDEKNLVQVYKYRGV"
     gene            7167..7586
                     /locus_tag="KR257_002658"
     CDS             7167..7586
                     /locus_tag="KR257_002658"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902379.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0031339.1"
                     /translation="MTVIELIVSISIILLIVTLSFPKDNLENHKINLFARQLCSDIRY
                     VRRINMFSNYNTYIYYINQGKHEGYVLRKDGKNIKSIMLPKNAKIARSIEIIKFKSDG
                     SPQKASTIEVYNNRLRKTITITPVSGRVLLKEGKYET"
     gene            7576..8100
                     /locus_tag="KR257_002659"
     CDS             7576..8100
                     /locus_tag="KR257_002659"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438204.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0031340.1"
                     /translation="MKHKYGYLLLESVVSLSSMVIIILVLYSIFLSTINLKLKVEDKI
                     ELQQQSLEIIKSMEGIISNSMGIMNVSNYEETFKKTTSIKCRYLDENNNEEGISNKEI
                     ILNERRNKLFVNSLNGESSQAGGYEIGDYVDEMYVSITNNGQYVNIKLKLSKCSQKYE
                     TDFKIKVWNFSESI"
     gene            8412..8969
                     /gene="efp"
                     /locus_tag="KR257_002660"
     CDS             8412..8969
                     /gene="efp"
                     /locus_tag="KR257_002660"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889023.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="elongation factor P"
                     /protein_id="HBH0031341.1"
                     /translation="MVSAGDFRKGVTFEKDGQPCLVVDFQHVKPGKGAAFVRTKYKNL
                     KTGAIREESFNPSEKFPKAVIDTRQMQYLYNDGELYYFMDQENFEQIPLNYEQVEDAI
                     KFLKENEVATIRFYQGQPFQVEAPNFAELEVTDTEPGIKGDTASNVTKAATVETGAVV
                     QVPLFINTGDKVKIDTRTGEYLSRV"
     gene            9061..9516
                     /locus_tag="KR257_002661"
     CDS             9061..9516
                     /locus_tag="KR257_002661"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419314.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="zinc ribbon domain-containing protein"
                     /protein_id="HBH0031342.1"
                     /translation="MKHLYEEVAYLKGLAEGLEISAESKEGKMIHKIVDALEVFADAI
                     VTLDEEQEELQDFVESIDEDLADLEEDIADMEEDLYEEDDDEDDEDFSYIEMECPNCG
                     ELVEIDEDLLYDDEVDVVCPDCKAVILSSEDDCDDDCTCGGCSSCDDRE"
     gene            9679..10389
                     /locus_tag="KR257_002662"
     CDS             9679..10389
                     /locus_tag="KR257_002662"
                     /EC_number="3.1.26.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428341.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribonuclease III"
                     /protein_id="HBH0031343.1"
                     /translation="MKISKKLLDNIQRFENVINYKFKNKEYILEALTHSSYSNENKKY
                     NFNERLEFLGDSVLGIVISDYLFNEEANLPEGELTKLRANIVCEDSLSEVANDINLGI
                     HMLLGRGEEATGGRHRTSILADAFEAVIAAIYLDGGFESARQFILHHMENIIYDSRKG
                     NIFRDYKTHLQEVLQGNGENNIWYRLIEEKGPDHNKRFVMEVGINDDVLGIGEGKSKK
                     EAEQLAAKIALKKKLWEK"
     gene            10443..11513
                     /locus_tag="KR257_002663"
     CDS             10443..11513
                     /locus_tag="KR257_002663"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438208.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="radical SAM protein"
                     /protein_id="HBH0031344.1"
                     /translation="MKKRIIPIFVPHKGCPHDCIFCNQKKITGVSTDVTSEDARNIIE
                     ECLETIDKDADVEIAFFGGSFTAIDIDIQKSLLSVAKEYVEKGLVKDIRMSTRPDCID
                     EDILSMLKEYKTSIIELGVQSLDEKVLLDSIRGHQSEIVYKSSKMIKNSGIKLGLQMM
                     IGLPADTEEKCIFTAKKFVELKPDCVRVYPTLVVKDTGLEKLMEQNKYNPFTLEESVN
                     IVKKVLVLFYVNNINVIRVGLQATDDIQIGKAVLAGPYHPAFRELVEADMIKDYLEFV
                     ILQNKNIKQMLVKSNKKNISKIIGNKKTNVKYMEEKFGVLLKTQESDLDINQLEIVLD
                     GKSLISANMRDIHRKLYDIYDL"
     gene            11541..15095
                     /gene="smc"
                     /locus_tag="KR257_002664"
     CDS             11541..15095
                     /gene="smc"
                     /locus_tag="KR257_002664"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896160.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="chromosome segregation protein SMC"
                     /protein_id="HBH0031345.1"
                     /translation="MYLKRLELKGFKSFPVKTDIIFKEGITAIVGPNGSGKSNISDAV
                     RWVLGEQSIKSLRGDKLEDVIFAGTDTKKPMNYCEVALTIDNSENQLELDFTEVTIRR
                     RAYRNGESEFFLNNKSCRLKDIKEVFLDTGIGKDGYSIIEQGKVDEILSNNPLSRRKV
                     FDEACGISKYRYKKQEAERNLSNTKENLERIDDVYIEIENQLKPLFNQQTKAKKYLEI
                     SEKLKTLEVNSFIREIEGIEKELSEVNEHRKVIEKELNEKEEQKNVVEKKQEDINKEV
                     EVLQDVIEKSVDYINSIKGVISKKESQINLIKERIRNFTNEISRKNLEINDIKEKLNE
                     NKQYIKELESNKLSGSEELSTLQENIKVLEASKDKQKIKLESLNNEIELLKESIIDIL
                     NKKQEFSNKLSTLNANKENMNIRDENINSEITELNKNIEIKSSELDTINKEFNMQNEN
                     LKNVNNRHKELSTNLQDSISEHNKLEDEIQKSKYNLNGYNSKLNVYIDMENHYEGFNR
                     GVKEVLKNKNLKGVHGALGQIINVPEKYEKSIEAALGAYMQNIITDNEFSAKSAINYL
                     KQNNLGRVTFLPLNIIKSNKISLGNLKANTKFIGIASDLITFDEKYRNIIENILGRTI
                     LINNIDEGIKFAKETGHRFKIVTLDGEILNPGGSLTGGSLKTNGNILSRKRYINEYTE
                     KISNIKNEISHLELKRESLDKDVKNIKNEIDSHESKIKDLEKSIIIKSTSIKNVESEI
                     ESLKGSITKLENEKNDLNSNLNYTLEKSDDVRKDMEELDDLYNKNKEKIDALNEEIKR
                     YNDLYDKEKSEFDELNLSLVKKTEVYNSIVRDIKRISGENCELEEKNKQLEESLNYEE
                     HEIIKLQDSILTEEKEKENLTKQLGDSNRNLETRKIAKDDLKNSFDEINKELKTIDRQ
                     HIELKESLFKVGGRLERLKTSQDTYINKLFEQYDMTLVQALEIKDEDLDIDRKFLESL
                     KREIRSLGNINIDSIKEYEEIKERYDFYSEQKQDLEESMEEIEKLIHTLEENMKSEFE
                     IKFEEISKNFKYVYKRLFGGGCGELTILDKENLLESDILITAQPPGKKMKNLNLLSGG
                     EKALTAISILFAILITKPTPFCILDEIEAPLDDANIFRFGEFLKDLSKETQFISVTHR
                     RGTMEAADYIYGVTMQEKAISKVISLKLKEAQEITDII"
     gene            15122..16402
                     /gene="ftsY"
                     /locus_tag="KR257_002665"
     CDS             15122..16402
                     /gene="ftsY"
                     /locus_tag="KR257_002665"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902385.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="signal recognition particle-docking protein
                     FtsY"
                     /protein_id="HBH0031346.1"
                     /translation="MLKKLFGFGKDKEKEIEKKDAEEEIEVEDSVDNLENLEETIFSG
                     LEEEVIDKVEDVEEKNEESVNNEGTEEIENFEKIEVEMDSNGKEVENISNNDSQEEII
                     EELENYDEIESKEIEDKEDKKVNLFERLKQGLTKAKQGITDRIDEVLKSYTKIDEELL
                     EDLEEILITADVGVNTTMDIIERLRDKIKQKGITEPIKVREELKSIVEDILTNENSTL
                     DIEPVPCIILMVGVNGVGKTTTIGKLANRYKKDGKKVLLAAADTFRAAATEQLEIWAN
                     RTNVDIIKHQEGADPGAVVFDAIKAAKARKTDVLICDTAGRLHNKANLMNELGKVFKI
                     VDREFPEAKREVLLVVDATTGQNAVVQAKTFKEVADITGIVLTKLDGTAKGGVVLAVK
                     SEVDVPVKLIGVGESVEDLQDFNAKSFSDALFGN"
     gene            16505..16873
                     /locus_tag="KR257_002666"
     CDS             16505..16873
                     /locus_tag="KR257_002666"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419333.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="putative DNA-binding protein"
                     /protein_id="HBH0031347.1"
                     /translation="MNIEKMVEIGLLFEQYKELLTDKQKEIVALYYEEDYSLGEISEN
                     LNVSRQGVYDTLKRSEKILRDYEEKLHLVSKIQEQEKNIKIIKDKIIDIKEDLLHNRD
                     CANLIPKLENIEDVCREMIK"
     gene            16870..18222
                     /gene="ffh"
                     /locus_tag="KR257_002667"
     CDS             16870..18222
                     /gene="ffh"
                     /locus_tag="KR257_002667"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419335.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="signal recognition particle protein"
                     /protein_id="HBH0031348.1"
                     /translation="MIFEGLSDKLQGAFSKLKSKGKLTEVDVKNAMREVKLALLEADV
                     NFKVVKDFIKKVQERCVGQEVMQSLTPAQHVIKIVNEELTSLMGDVQSKVMISSKPPT
                     ILMMVGLQGAGKTTTAGKLGGYFKKQGKKPLLVACDIYRPAAIKQLQVVGEKLDIPVF
                     NMGDKENPVNIAKAGLSHAIKNANDLVIIDTAGRLHIDEVLMDELKSIKSEVKPHEIL
                     LVVDSMTGQDAVNVAESFNEALGVDGVVLTKLDGDTRGGAALSIRAVTQKPIKFMGMG
                     EKLDDIEPFHPDRMASRILGMGDVLSLIEKAQENIDLEKAKELEQKIKKQELDFEDFL
                     QQMEQIQNMGPLDKILGMIPGMGNVKDQLGDVDLNGKEMKRTKAIIQSMTTYERRNPG
                     VLNASRKKRIAKGSGTSVQDVNRLIKQLNEMKKMMKMFAGSQKSMKKRGGLGGLPFFK
                     "
     gene            18260..18532
                     /gene="rpsP"
                     /locus_tag="KR257_002668"
     CDS             18260..18532
                     /gene="rpsP"
                     /locus_tag="KR257_002668"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000268750.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S16"
                     /protein_id="HBH0031349.1"
                     /translation="MAVKIRLKRMGANKKPFYRIVVADSRAPRDGKFIEEIGYYNPIS
                     EPKQVRINDEKAIKWLATGAQPTEVVKKLLVKNGVIEKFEASKQAK"
     gene            18597..18824
                     /locus_tag="KR257_002669"
     CDS             18597..18824
                     /locus_tag="KR257_002669"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419342.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="KH domain-containing protein"
                     /protein_id="HBH0031350.1"
                     /translation="MKELVVDIAKALVDNPDSVVVEEFEDNDGIVLKLTVAQEDMGKV
                     IGKQGRIAKAIRTVVRSVANRENIKVSLEIV"
     gene            18932..19447
                     /gene="rimM"
                     /locus_tag="KR257_002670"
     CDS             18932..19447
                     /gene="rimM"
                     /locus_tag="KR257_002670"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438220.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="16S rRNA processing protein RimM"
                     /protein_id="HBH0031351.1"
                     /translation="MKEKLTHFKVGQIVNTQGLKGEVRVYPLTDDIERFDELKDFYLG
                     KDLNNKLAVEKVRYKGSMVIMKIKGIDSIEKAEKLKNKFMYVSREDSRELEEGEFFIA
                     DMIGMEVLTVDGKYVGILEDVLQYSANDVYVVKGEEDKEFMIPAIKKFVPTIDIDERK
                     MIIDPIKGMID"
     gene            19456..20151
                     /gene="trmD"
                     /locus_tag="KR257_002671"
     CDS             19456..20151
                     /gene="trmD"
                     /locus_tag="KR257_002671"
                     /EC_number="2.1.1.228"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000686892.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA (guanosine(37)-N1)-methyltransferase TrmD"
                     /protein_id="HBH0031352.1"
                     /translation="MRFHIMTLFPEIFNSYMDESIMKRAVEKGIIEVHIYNIRDFSNN
                     KHKKVDDYPFGGGAGMVMTPQPIYDTYKHIITTHNINNPSVIYLTPKGKVYNQSMAKQ
                     MSLKEDIILLCGHYEGIDERIIDLIVTDEISIGDYVLTGGELPALIMIDSISRLIPGV
                     LNQEESFEEESFKDNLLEYPHYTRPRDFEGLKVPEVLLSGNHKKIDEWRREESIRITK
                     ERRFDLYKKSNEK"
     gene            20336..20686
                     /gene="rplS"
                     /locus_tag="KR257_002672"
     CDS             20336..20686
                     /gene="rplS"
                     /locus_tag="KR257_002672"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419350.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L19"
                     /protein_id="HBH0031353.1"
                     /translation="MNEMLRAIEQEQLKNEVPNFGPGDTVKVHVRIIEGKRERIQVFE
                     GVVLKRQGGGARETFTVRKMSFNVGVERTFPVHSPKIEKIEVTRKGKVRRAKLNYLRG
                     RVGKAAKIKEARNK"
     gene            21007..21903
                     /gene="ylqF"
                     /locus_tag="KR257_002673"
     CDS             21007..21903
                     /gene="ylqF"
                     /locus_tag="KR257_002673"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428326.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribosome biogenesis GTPase YlqF"
                     /protein_id="HBH0031354.1"
                     /translation="MSNEYEEYLMDDNLHINWYPGHMKKTKELVKNNLKLIDVVIELL
                     DARIPFSSKNPDIDRLVGDKPRVVVLNKSDMADRDKLNQWIEYYKKINIKAIPVDTIK
                     GVGINKIIEECKNVTREKMSSLKDKGRKERAIRIMIVGVPNVGKSSLINKLTGRKSTQ
                     TGDKPGVTKGKQWVRLKGNLELLDTPGILWPKFEDQEVALNLAFSRAIKDEILDTETL
                     ALRLIEKLMKIEPEKLKARYKLDCLGETPIETMDMIGHKRGFITGKKELDYTRIATTV
                     LNEFRDGKIGNITLEVPENVKR"
     gene            22292..>23567
                     /gene="brnQ"
                     /locus_tag="KR257_002674"
     CDS             22292..>23567
                     /gene="brnQ"
                     /locus_tag="KR257_002674"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438230.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="branched-chain amino acid transport system II
                     carrier protein"
                     /protein_id="HBH0031355.1"
                     /translation="MGKTKDVIVFGFALFAMFFGAGNLIFPPYLGIITGPEWLIAFLG
                     FTFADAGLALLAVMATAKFDGNVVEMFKRCGMKLGILIGCADILCIGPFLAIPRTGAT
                     TYEMGIMPLFGTSIPVLLFCILFFALSYVLTIRPSKVVDIVGQFLTPALLIALAFIII
                     KGIISPLGDIVDKPMIPNVFAEGIGQGYQTMDAFAAIALASVLIVSLNDKGYSTISDK
                     LKMIGKAGVLACGGLALVYGGLCFLGATVSTMYGTDAVQSQVIVNITEGLLGNVGKAI
                     LAVVVSLACLTTSIGLTSATGQYFSRLTKGKLSYEKIVLAVSVFSAVVASFGVGTIIK
                     IASPILSIVYPPSIVLIILAFFNEKIKNDNVYKGAVYMSLLVSILTVISSYGVAVPVV
                     NSLPLNSLGFNWVVPVIIAGIIGNFIPSKSQSN"
BASE COUNT         9924 a         2287 c         4329 g         7027 t
ORIGIN      
        1 taacaaaaaa gatgtaatta tcgacgttcc aagtggagca tctgttggaa aaatatctga
       61 catattatat gaaaataaat taataaagaa tgaactatta tttaaacttt tggtaaaggt
      121 tagcaataag gctccgtcta taaaatcagg aacatactta cttaatcaat cgtattcaaa
      181 caatgatata ataagtcttt tagtttcagg taaaatatat caggatggta taaaagtgac
      241 tattccagag ggagctacat ctaaagaaat tatagcaatg ttagtaagta aaaatttagg
      301 agataaagct acttttgaaa atttaataaa aaaacctcaa gaattttatg ataaatttcc
      361 atatttgaag gaagatggaa taacctcttt agaagggttc ttgtatccag aaacttatta
      421 ttttaattca aagaaacaat cagaagaaga tattttaagc gaaatgttaa aagtatttga
      481 cagtaaatac acggacaagt ttaaaaagaa acaaaaagaa ttaaatatga ctcttcaaga
      541 agtaatggaa atggcatcaa taattgagaa agaagctgtt cttgacaaag acagacctat
      601 aatagcaagt gtgttttata atagacttaa ggtaggtatg cctcttcaat cagatgctac
      661 aatacaatat atatttgaag agagaaagaa aattgtaaca tatgatgatt taaaaattga
      721 ttcaccatat aatagttata aaaataaggg attacctcct acaccaatat caaatcctgg
      781 tataaaatct attgaagcag cattatatcc agagaaaaca gactatttat attttgtagc
      841 taagattgat ggtggaaata attatagtac aaactatcaa gaccatttaa aatacgttaa
      901 agaatataaa gaagcaaggg ataaacaatc aaaagataca aaagcaacaa ataaagaaaa
      961 tacaaaaaaa taaaccatga ttataaaaag tctaacaggg taagaataat gttgggcttt
     1021 tttattgaaa attgttattc ttagatttat aataaagaaa gtgtaaatat atataacaat
     1081 atgaatttaa aaaataataa attaatataa aacttgaata tttattattt tagggagtgt
     1141 ttttatgagt aatatagtta atgatttggt tgaagattat ataagagtga cattaaaaga
     1201 aaaagaagga tttttaaaag atttagaaat ttatgcagag gaaaatagtg ttcctataat
     1261 acataaagaa gtttcagatt tattaaaagt cttgttaaag gttcaaaaac caaagagaat
     1321 tttagaagta ggatgtgcaa ttggttattc ttctattttt tttgcaacta ttataggaaa
     1381 agatgcagat ataataactg ttgagagaaa tgaaaaaatg atagaaaaag caaaagaaaa
     1441 cataaaatta gctggatttg acaataacat aactatacta gaaggagatg cagaagaaaa
     1501 acttagtcaa gtccaaggtg aatttgacct tatatttata gatgcagcca aaggtcaata
     1561 taagctattt tttgatttag ttatagataa attaaaagat gggggacttt tagtatctga
     1621 taatattttg tataaaggta tggttgctca tgatgatttt gttgtaagaa gaaaaaagac
     1681 tatagttaaa agaatgagaa attatttaga ttatatatgt aattgtgact atttaagcac
     1741 atcattggta ccaataggtg atggtgtagc actaagttat aaagaaagta aaagaggtga
     1801 tgtagatgga attaaataaa gtagaacttt tagctccagc tggtgatttg gagagattga
     1861 aaatagctat aacatatgga gcagatgccg tttatatagg tggagaaatt tttggaatga
     1921 ggtctgcagc gaagaatttt agtaaggaag atatggcaga gggagtagct tttgcacatg
     1981 aaagaggcaa gaaagtattc gtaacagtaa atataatacc tcataatgaa gattttctac
     2041 aattagaaga ctatttgttg gaactagaag agataggaat agatgcagtt ataatagctg
     2101 acccaggagt gcttagtgtc attaaaaaag taattccgaa tatggaaata catttaagta
     2161 cacaagcaaa tacaaccaat tatctaagtg caaacttctg gtacgagcat ggaataaaaa
     2221 gagttgtagt ggcaagagaa ttatcttttg atgaaatatc tgagataaga gcaaaaacac
     2281 ctttagatat ggatatagaa gcgtttatgc atggtgctat gtgtatttct tattctggca
     2341 gatgtttaat aagcaactat atgactggaa gagatgcaaa caaaggttct tgtgctcaat
     2401 cttgtagatg gcaatatcat ttggtggaag aaaaaagacc tggtgagtat tttccaatat
     2461 acgaagatga aaggggtaca ttcttcttta actcaaaaga tttatgtatg atagagtata
     2521 taccagagtt aatcaaatct ggtataacaa gtttaaaaat agaaggtaga atgaagactg
     2581 catactatgt agctactgtt gtaagagcat acagaatggc aatagatgaa ttttacagag
     2641 acccagaaaa ctggaagttc aatccaatgt ggatggaaga actaaaaaaa ggtagtcata
     2701 gacattttac atcaggtttt tacttgaata aaccaacaac agaagaccaa aattatcaat
     2761 cagcatcata tgttagaaac tatgatttta taggtatagt tagagaaaca gaagatgaag
     2821 atggtcttat tgttgttgag caaagaaata aaatgtgtgt tggtgatgaa atagaagtta
     2881 tgggaccata taaagaaact atgtttacta aaattgaaga aatgtacaat gaagaaggag
     2941 aagctataga atcagctcct catcctagac aaatagtgaa gttaaagcta tcagtaaaag
     3001 ttggtaaaga ttatatgctt agaaaagtta tagaagaaaa ggttgaagaa taataaaaaa
     3061 ttgataaaaa tagtattagc cccttagaaa ttgtcaataa tgaaattatc taaggggtga
     3121 tttcatgtca aaaaagaaga ctccattttt gaaaaaagtg ggaaagagaa gctggtgtat
     3181 atttactata attttaataa tttatagtgt tttaatttat aggctagttg atatacaagt
     3241 attaaaaggt gataaataca aacaaagtgt tgaatcacaa agcgttgaga aagtcgagtt
     3301 aaatagtgga agaggaataa tctatgatag aaacaacaag aagcttacag atacaagtaa
     3361 atctcaggta ttaattgttg aaaaagaaaa attaaataat aactataaaa ttttggagct
     3421 tattaagaaa gctactaaga tgaatgattt agatatatat aaagctgtac aagagcaatt
     3481 gacacgccct ataatacaga ttcagactaa aaatatcgat aagagtatga aaaaagaact
     3541 tgagaaaaat ggaataatgg tagaagaaaa aactatgagg tacgcaaaag atggtttatt
     3601 atcacataca ataggatata taaaagaaga tgataaatca ggtcaatcag gaattgaaaa
     3661 gagtatggat agtgtactta gaaattcaaa tgaaaagtat ataagtgctt ttaaagctgg
     3721 agatgcagga aatgaaaaat ctctaaacat actaaaggga agtgtaaaaa ctgttgataa
     3781 taaggataaa gatagacatc taaaaactac tattgattat aacattcaaa aaaaattaga
     3841 acaaatacta aataaagaag aaaatcctac agcagcaata atctcggaag catctacagg
     3901 tgaaattctt gcaatgtgct ctagacctaa ttttgaccaa aatgacatat caaaaagttt
     3961 aaaaggaaaa aatggagaat ttgaaaatag agttataaaa gcgacatatc caccagggtc
     4021 tgtatttaag atggtagttt tattttctgc acttgaaaat ggtgttatag atgagaacta
     4081 tacttacaac tgtacaggta agactaaagt tgggaatact aatgaaatac tgcgatgtaa
     4141 taaaagagat ggtcatggtt tccaaaactt aagacaagct ttttctaatt catgcaatcc
     4201 tgcattttta gatatagcta tgaaacttgg aaaagaaaag atactcaaat ctgctgaaaa
     4261 attacattta tttgaaaagg ttgatattgg tcttgatgaa gaaaaaatta gagaagctcc
     4321 aaaaaacata tcaataagaa atttagctat aggtcaagaa aatatagaat ttacaccact
     4381 tcaaataaat caaatgactc aaataatagc taataatgga acattcaaac cactatactt
     4441 atataaaagt cttgtggaca ataatatgaa tacaataaaa acttataagt cttcaaaaaa
     4501 agaagaactt atttctcctt atgtgtgtac acaagttaaa gaatatatga agtctgtatc
     4561 taggattggt acagctaaag acctaaaaga tattgaaggt ggttgtggag ttaaaactgg
     4621 tacagctcaa agtagtttaa ataaaaaagc tatagaccat ggatggataa caggatttta
     4681 tcctgaagaa agacctaagt atgtaataac tgtgttagta gaaggaactc aaaaaggaaa
     4741 taaatctgca acacctatat ttaaggaaat atgtgaaagt ataaaataaa ttatgtacta
     4801 taaaatttaa ggatatatcg taactttgat tttagataga aaattttgtc taatgatgta
     4861 cgatatatcc ttttaaaata tagtattaac tttcttgaac aagctctttt tctagttttt
     4921 taagagcttt tttttcgatt ctagatacat atgaccttga tatatcgagt ttttgtgcaa
     4981 tttctctttg tgtcttatag ccataaggag ttaacccata tcttaactgg acaatttctc
     5041 tttctctagg agtaagaatt ttgtttagtt gttcgtaaag ttttccaact tgaactttta
     5101 gttcaacttc atcaagaaca tagttagcct ctgtaccaag tatatctaaa agacttattt
     5161 cattaccttc tttatctgtt ccgatagggt cttgtagaga tacttgagtt ttattttttt
     5221 tgttagatct aatattcatt aaaatctcat tttcaataca tctagaagca tatgttgcta
     5281 atcgagttcc tttatctatg ttataagttt ctatagcttt aattaatcct attgtaccta
     5341 tggatattaa atcatcctga tcttccgttg aattattata tttctttgct atataagcta
     5401 ctaatctcat gtttctttca attaatgtat cttttgcact tttatcgttt tctattttaa
     5461 atttagttaa atactcaatc tcttcttcag gggttaaggg tttttcaaaa gatttaagag
     5521 ctgccaatag gtcaccccct tttcaacggt cactttaaat tatatgaagg agacttatcc
     5581 aagttgactg ttatctaata aaataatatg catattttta gaatttaaaa catatatttg
     5641 caaacttttg aatggaatat gacataaaga gtgggaattt aaatttaagt ttttgttgta
     5701 tatatatgaa acaaggcgaa gaaattattg atttataaag tataaattgg aattgaggtg
     5761 tcaataaata taaaaggaaa tagtatttat atatgttttg gtgttgaagt aaaagattaa
     5821 tgcaaagcat tagagtctat aaaaatatga atataggagg tgtaatttta caatacttaa
     5881 aaaagtaaat gtaattaatt gtttgtataa agttgattac aagcaaaagt atcagtcata
     5941 gttaatactg ttaaggatga aggtggtgtg ttaatttata tatgtatggg aagaaatttt
     6001 gattacaatg aaaaaactta caaaagatat ttacgaaaaa acttatagtt aaatgtttat
     6061 atataaaata ttatttaggg gttgttttta ttattgaaaa taagaaagag tggttttata
     6121 tcaattgaat gtataataag tattgctata ttatatgtgg ctgtttattt agtttctaca
     6181 tcattgtata attgttatag ttttatcagt agaaatatat ctgacagaga aatgttaagt
     6241 acagcaaaaa aatatataga agatgagaag tatagaatac aaaatagtaa gtatgagtta
     6301 attgaagata agatagaaaa aaattacata aatggatatg aaattaacag tagaatagag
     6361 caaattttag attattatca atgctatgaa ataaatatag agataaaaaa tgaatttaaa
     6421 aaactgaggt ttaatagcta tgttactaga aaataaaggc tctatattaa taataacatt
     6481 gataatattt tctattataa gtactgtgtg cattatgtgt ataggtttaa tttatacaca
     6541 taataatatg tttgagttag gatacaaaga cattcaacta aaagaaattt ctttaagtgg
     6601 aatagaaata tcagtaagta atgtactttc ttgtgttgag gaagctattg atatatctaa
     6661 taatgaagac gaatttagag aatatttctt aggaaataat atgattgaat gtataaaaaa
     6721 aataaaagat acatcttata gtagtttaga agaactttct ttaaaagtag aaaataatac
     6781 tatttatgac agaggagatt tttttgaatt tgatatagaa agtaatgtta gagaaaaaga
     6841 atttttaaaa gcaataaaag taagagtgaa aatcaaaaat ccatggatag gaattgatat
     6901 tgaagattat atggataaat ctaataacaa taaaattgat gacaaaacat tcaataatta
     6961 taaagcatct gaaaataatg aaattataaa tcaatttaaa aatgaaagtg aaaatataag
     7021 gaatcaagag gttgttgaat ttacagaaga agatgaagaa gaacttaaac aaaacataat
     7081 tgaaaatata aagaagaatt ttgatgaaaa aaacctagta caggtatata agtatagggg
     7141 tgtataactt tgaaaaaaga aggaatgtga ctgtaataga attaatagta tctatcagta
     7201 taatactctt gatagttaca ttatcttttc caaaagataa tcttgaaaat cataaaataa
     7261 atttatttgc acgtcaactt tgttcagata taaggtatgt taggcgaatt aatatgttta
     7321 gcaactacaa tacatatata tattatataa atcaaggtaa acacgaaggt tatgtattga
     7381 gaaaagatgg taaaaacatt aaatcaataa tgctacctaa aaatgcaaaa atagctagga
     7441 gtattgaaat aataaagttt aaatctgatg ggtcgcctca aaaggcgtct acaatagagg
     7501 tatataataa tagattaaga aaaactataa caataacacc tgtaagtgga agagtacttc
     7561 tgaaagaggg aaaatatgaa acataaatat ggttacttgc ttttggaaag tgtcgtatca
     7621 ttgtcttcaa tggtgataat tatactagtt ttatattcta tatttttgtc tacaataaac
     7681 ttaaagttaa aagtagaaga taagatagaa ctacaacaac aaagtcttga aatcataaaa
     7741 tctatggaag gaattattag caattctatg ggaataatga atgtatctaa ttatgaagaa
     7801 acatttaaaa agacaacatc tataaaatgt agatatttag atgaaaataa taatgaagaa
     7861 ggcataagta ataaagaaat tatattgaat gaaagacgaa ataagttatt tgtaaattct
     7921 ttaaatggcg aaagtagtca agcaggtggt tatgaaattg gagattatgt agatgaaatg
     7981 tatgtatcaa ttactaataa tggtcaatac gttaatatta aattgaaatt atcaaaatgt
     8041 agtcaaaaat atgagactga tttcaaaata aaagtatgga attttagtga aagtatataa
     8101 aaatacataa atttaagaga aagaaatgac atcaataagt catataaaat ataattattg
     8161 agaactatat aactaaataa tatcaatatg taaagtgtat agattaagaa tatagaggat
     8221 aataataaaa atatagaata agtaatttgc caaatacttg tttatattgt ataacttatg
     8281 atattatgat attagtaaaa atttgtaatc ctgacttgac agaattcaag taagagatat
     8341 aattttaaag gcatagtaat gtaaaattta ctaaaaaata agaaatttat tttaatatgg
     8401 aggaacaaaa aatggtatca gcaggtgatt ttagaaaagg tgttacattt gaaaaagatg
     8461 gacaaccatg tttagtagtt gattttcaac acgttaagcc aggtaaagga gctgctttcg
     8521 ttagaactaa atacaaaaac ttaaaaacag gagctataag agaagaaagt ttcaatccaa
     8581 gtgaaaaatt ccctaaagct gttatagata caagacaaat gcaatatcta tacaatgatg
     8641 gtgagttata ttattttatg gatcaagaaa attttgaaca aataccatta aactatgagc
     8701 aagttgaaga tgcaattaag ttcttaaaag aaaatgaagt tgctacaata agattttacc
     8761 aaggacaacc attccaagtg gaagcgccaa actttgcaga gctagaagtt acagatacag
     8821 agccaggcat aaaaggtgat acagcaagta atgtaactaa agcagctaca gttgaaactg
     8881 gagcagttgt tcaagttcca ttatttataa atactggaga taaagtaaag atagatacta
     8941 gaacaggtga atatttatca agagtataaa aatttatgta tataaaagct tatatgtctt
     9001 aataatataa gatatatgag cttttagttt atatataaaa aagaaagcga ggggtgttac
     9061 atgaaacatt tatatgaaga agttgcatac ttaaaaggcc tagcagaagg actagaaata
     9121 agtgctgaaa gtaaagaagg gaaaatgata cataaaatag ttgatgcatt agaagtattt
     9181 gcagatgcta ttgtaacatt ggatgaagaa caagaagaac ttcaagattt tgttgaatct
     9241 atagatgaag atttagcaga tttagaagaa gatattgctg acatggaaga agatctttat
     9301 gaagaagatg acgatgagga tgatgaggac ttcagctata tagaaatgga atgcccaaat
     9361 tgtggagagt tagtagaaat agacgaagat ttgttatatg atgatgaagt agatgttgtt
     9421 tgtcctgatt gtaaggctgt gatattatca tcagaagatg attgtgatga tgattgtaca
     9481 tgtggtggtt gttcaagttg tgatgataga gagtaaaaat tcataagaat taaaactgcc
     9541 tatgatgcct atgagatatt ttgcttcata ggtagtttta tttttatgag gaagggtatt
     9601 atgtattttg gttttgcaat acttggacaa aaatagtaca ctagaattta tagaatagga
     9661 ttttggaggg atgtaaatat gaaaataagt aaaaaattac tagataatat acaaagattt
     9721 gaaaatgtta taaattataa atttaaaaat aaagaatata tactagaagc tcttactcat
     9781 agttcatatt ctaatgaaaa taaaaaatat aattttaacg aaagattgga atttttaggg
     9841 gattcggttt taggcatagt gataagtgat tatttattta atgaagaagc taatctgccc
     9901 gaaggggaac taactaaact tagagcaaat atagtctgtg aagattcatt aagtgaagta
     9961 gctaatgata taaatttagg tattcacatg ttattaggta gaggagaaga agcaacagga
    10021 ggaagacata ggacttcaat attagcagac gcatttgaag ctgtaatagc tgctatatat
    10081 cttgatggag gttttgaaag tgcaagacag tttatacttc atcatatgga aaatataatt
    10141 tatgattcaa gaaaaggaaa tatatttaga gactacaaaa cgcatcttca agaggtgtta
    10201 caagggaatg gagaaaataa tatctggtac aggcttatag aagaaaaagg accagaccat
    10261 aataaaagat ttgtaatgga agttggaatt aatgacgatg tacttggtat aggagaaggc
    10321 aagagtaaaa aagaagctga acagttagct gctaaaatag ctttaaagaa aaaattatgg
    10381 gaaaaataaa tataatatgt aaaaatataa aaagaaatat ttatattaga aggatgttgt
    10441 agatgaaaaa gagaattata cctatatttg ttcctcacaa aggatgtcct catgattgca
    10501 tattttgtaa tcaaaaaaaa ataacaggtg tgagtactga tgttactagt gaagatgcaa
    10561 gaaatataat tgaggaatgt ttagagacta tagataaaga tgcagatgta gaaatagcat
    10621 tttttggtgg tagctttact gctatagata ttgatataca aaaaagttta ttatcagttg
    10681 ctaaagaata tgtagaaaaa ggtcttgtaa aagatattag aatgtctaca agaccagatt
    10741 gtattgatga agatatatta agtatgttaa aagaatataa gacaagtata attgaactag
    10801 gagtacaatc cttagatgaa aaagtattat tagatagtat aagaggtcat caatctgaaa
    10861 ttgtatacaa gagttcaaag atgataaaaa atagtggaat caaacttgga ttacagatga
    10921 tgattggtct tccagctgac acagaagaaa agtgtatatt tacagcaaaa aaatttgtag
    10981 agctaaaacc agattgtgtt agagtctatc caactttggt agtaaaagat acaggtcttg
    11041 aaaagttaat ggaacaaaat aaatataatc catttaccct tgaagagagt gtaaatatag
    11101 taaaaaaagt tcttgtactg ttttatgtta ataatatcaa tgtaataaga gttgggcttc
    11161 aagctactga tgatatacaa attggaaaag ctgttttagc aggaccatat catcctgcat
    11221 ttagagagtt ggtagaagca gatatgataa aagattattt agaatttgtt attttgcaaa
    11281 ataaaaatat aaagcaaatg ttggtcaaat ctaataaaaa gaatatttct aaaatcatag
    11341 gaaataaaaa aacaaatgtt aaatatatgg aagaaaaatt tggtgtgctt ttaaaaacac
    11401 aagaatcaga tttagatata aatcaattag aaattgtgtt agatgggaaa agtttaatta
    11461 gtgctaatat gagagacatt catagaaaat tgtatgacat ttatgacctt tagttttaat
    11521 aatgaaggga gagaaaagat ttgtatttaa aaagactaga gttaaaggga tttaaatcct
    11581 ttccagtaaa aacagatatt atttttaaag aaggaataac agccatagta ggaccaaatg
    11641 ggagtggaaa aagtaatata tctgatgctg taagatgggt attaggagaa cagagtatta
    11701 agagtcttag aggtgataaa ctcgaagatg taatatttgc aggtacagat acaaaaaaac
    11761 ctatgaatta ttgtgaagtg gctcttacta ttgataattc tgaaaatcaa ttggaattag
    11821 attttacaga agtaactata agaagaaggg cttatagaaa tggtgaaagt gaattttttc
    11881 taaataataa aagttgtaga ttaaaagata taaaagaagt ctttttagat actggtattg
    11941 gaaaagatgg ttattcaatc atagaacaag gaaaagtaga tgaaatatta agtaataatc
    12001 ctttaagcag aagaaaagtt tttgatgaag cttgtggcat atcaaaatat agatataaaa
    12061 aacaggaagc agaaaggaat ttaagtaata caaaggaaaa tttagaaaga atagatgatg
    12121 tatatataga aattgaaaat caattaaagc ctctttttaa tcaacagaca aaggcaaaaa
    12181 agtacttgga aataagtgaa aaattaaaga cacttgaagt aaatagcttt ataagagaaa
    12241 ttgaaggaat agaaaaagaa ttaagtgagg ttaatgaaca tcgtaaggtt attgaaaagg
    12301 agctcaatga aaaagaagaa caaaaaaatg ttgtagagaa aaagcaagaa gatattaata
    12361 aagaggtaga ggtattacaa gatgtaattg aaaaatctgt agattatata aattcaatta
    12421 aaggagttat atcaaaaaaa gagtcccaaa taaatttaat taaggaaaga ataagaaatt
    12481 ttacgaatga aattagtaga aaaaatttag aaataaatga tataaaagag aagctaaatg
    12541 aaaataagca atacataaaa gaattagaaa gcaataaatt atcaggtagt gaagaactat
    12601 ctaccttgca ggaaaatata aaagtattgg aagcaagtaa agataaacaa aaaattaagt
    12661 tagaatccct aaataatgag atagaattat tgaaagaaag tataattgat atattaaata
    12721 aaaaacaaga gtttagtaat aagctgtcca ctttaaacgc aaataaagaa aatatgaata
    12781 tcagagatga aaatataaat tcagagataa cagagttaaa caaaaatatt gaaataaaat
    12841 catctgaatt agatactata aataaagaat ttaatatgca aaatgaaaat ttaaagaatg
    12901 taaataatag acataaagaa ttatcaacta atttgcagga ttcaattagt gaacacaata
    12961 aactagaaga tgaaatacag aaaagtaaat ataatttaaa tggatataat tcaaagttaa
    13021 atgtctatat agatatggaa aatcattatg aaggatttaa tagaggagta aaagaagtac
    13081 taaaaaataa aaatttaaaa ggagttcatg gagcattagg acagattata aatgtacctg
    13141 aaaaatatga gaaatctata gaagcagctc ttggtgctta tatgcaaaat ataataactg
    13201 ataatgagtt tagtgctaag tctgcaataa actatctaaa acagaataat ttaggtagag
    13261 taacatttct tccattaaat ataattaaat caaataaaat aagtctagga aatttaaaag
    13321 caaatactaa gttcatagga atagcaagtg atttaattac atttgatgaa aagtatagaa
    13381 atataattga aaatatactt ggaagaacaa tacttataaa taatatagat gagggcataa
    13441 aatttgcaaa agaaactggt cataggttta aaatagtaac tttagatggt gaaatcttaa
    13501 atccaggagg ttctttgact gggggaagtc taaaaactaa tgggaatata ctatccagaa
    13561 aaagatacat taatgaatat acagaaaaga taagtaatat caagaatgaa atttcacatc
    13621 tagaattaaa aagagaatct ttagacaaag atgtgaaaaa tatcaaaaat gaaattgatt
    13681 cacatgaaag taaaataaaa gatttagaaa aaagtataat aataaaaagt acaagtataa
    13741 agaatgttga gtctgaaatt gaatcgttaa aaggtagtat tactaaatta gaaaatgaga
    13801 agaatgattt aaattctaac ctaaattata cacttgaaaa aagtgatgat gttagaaaag
    13861 atatggaaga gttagatgat ttatacaata aaaataaaga aaaaattgat gcattgaatg
    13921 aggaaataaa aagatacaat gatttatatg ataaagaaaa atctgaattt gatgaattga
    13981 acttaagttt agtgaagaaa acagaagttt acaatagtat agttagagat ataaaaagaa
    14041 tatctggtga aaattgtgag ctagaagaaa aaaataaaca attagaagag tcattaaatt
    14101 atgaagaaca tgaaataatt aaattacaag attctatact cactgaagaa aaagaaaaag
    14161 aaaatttaac aaaacaacta ggggatagta atagaaatct tgaaactaga aaaatagcaa
    14221 aagatgattt aaaaaatagt tttgatgaaa ttaataaaga attaaaaact atagatagac
    14281 agcatataga acttaaagaa agtttattta aagttggtgg aagattagaa agattaaaaa
    14341 ctagtcaaga cacatatata aataagttgt ttgagcaata tgatatgacc ttagtacaag
    14401 cattggaaat taaagatgaa gatttggata tagatagaaa attcttagaa agtctaaaga
    14461 gagaaataag aagtcttgga aatataaata tagactctat aaaggaatat gaggaaataa
    14521 aagaaagata cgatttttat agcgaacaaa agcaagattt agaagagtct atggaagaga
    14581 tagaaaaact tatacatact ttagaagaaa atatgaaatc tgaatttgaa attaagtttg
    14641 aagaaataag taaaaatttt aaatatgtat ataagagatt atttggtgga ggttgtggag
    14701 aattaactat tttagataaa gaaaatttat tagaaagtga tatactaata acagctcaac
    14761 ccccaggtaa aaaaatgaaa aatttaaacc tattatctgg tggagagaaa gctttaacgg
    14821 caataagtat attatttgct atattgatta caaagccaac accattttgt atattagatg
    14881 agattgaagc gccacttgat gacgcaaata tatttagatt tggagaattt ttgaaggatt
    14941 tatctaaaga gactcaattt atatcagtaa ctcataggag aggaactatg gaagctgctg
    15001 attatatcta cggagttaca atgcaagaaa aagccatttc aaaagttatt agtttaaaat
    15061 taaaagaagc tcaggaaata acagatatta tataacttag attgacatag gaggaataac
    15121 agtgttaaaa aaattatttg gttttggaaa agacaaggaa aaggaaatag aaaaaaaaga
    15181 tgctgaagaa gaaatagaag ttgaagacag tgttgataat ttagaaaact tggaagaaac
    15241 tattttttca ggacttgaag aagaagtgat agataaagtg gaagatgttg aagaaaaaaa
    15301 tgaggaaagt gtcaataatg aaggcactga agaaatcgaa aactttgaaa aaatagaagt
    15361 tgagatggat agtaatggaa aagaagtaga aaatatttca aataatgatt ctcaagaaga
    15421 gataatcgaa gaattagaaa attatgatga aattgagtct aaagagatag aagataaaga
    15481 agataagaaa gttaacttgt ttgaaagact aaaacaagga ttgacaaaag caaagcaagg
    15541 aataactgat agaatagatg aagttttaaa atcatataca aagatagatg aagaattact
    15601 tgaagattta gaggaaattt taataacagc agatgttggt gtaaatacaa ctatggatat
    15661 aattgaaaga ctaagagata aaataaagca aaaaggtatt actgaaccaa taaaggtaag
    15721 agaagaactt aaatctatag ttgaagatat tcttacaaat gaaaactcta cactagatat
    15781 agaaccagta ccatgtataa tattaatggt gggtgtaaat ggggtcggta agactactac
    15841 aataggtaaa ctagcaaata gatacaaaaa agatggtaaa aaagttttat tagcagcagc
    15901 agatacattt agagcagcag caacagagca attagaaatt tgggcaaata gaaccaatgt
    15961 agacataata aaacatcaag agggagcaga ccctggagct gtagtatttg atgctataaa
    16021 agctgcaaaa gctagaaaaa cagatgtatt aatatgtgat acagcaggaa gattacacaa
    16081 taaggctaat cttatgaatg aacttggaaa agtatttaaa atagtagata gagaatttcc
    16141 agaagcaaaa cgagaagtac ttcttgtggt ggatgctaca acaggtcaaa atgcagttgt
    16201 tcaagcaaag acatttaaag aagttgcaga tataacaggt atagtactta caaaacttga
    16261 tggaactgca aaaggtggag tagtccttgc ggtaaaatca gaagtagatg tacctgtaaa
    16321 acttattgga gttggagaaa gtgtagaaga cctacaagat ttcaatgcaa aatcattttc
    16381 agatgcatta tttggtaact aatgttcttt taaaaataat ggttgacaag agtgttgtta
    16441 tgatataaaa tacaatagtg taaagtaaat aacctttaca gtatactgct aggaagtgta
    16501 agatatgaat atagaaaaaa tggtcgaaat tggattgtta tttgaacagt ataaagaatt
    16561 attaactgac aagcagaaag aaatagttgc tctatactat gaagaagatt attctttagg
    16621 tgaaattagt gaaaatctga atgtatcaag acaaggtgtt tatgatacct taaagcgttc
    16681 agaaaaaata ctaagagatt atgaagaaaa gttacactta gtatcaaaga ttcaagagca
    16741 ggaaaaaaat attaagatta taaaagataa aattattgac attaaagaag atttattgca
    16801 caatagagat tgtgctaatt taatccctaa gctagaaaat atagaagatg tatgtaggga
    16861 gatgataaaa tgatatttga aggattgtct gataaactac aaggggcatt tagtaagtta
    16921 aaatctaaag gaaaacttac agaagtagat gtaaaaaatg ctatgagaga agttaaactt
    16981 gctcttcttg aggcagatgt taactttaaa gtagttaaag atttcataaa aaaagttcaa
    17041 gagagatgtg ttgggcaaga agttatgcaa agcttaactc cagctcagca tgtaatcaaa
    17101 attgtaaatg aagagcttac aagtttaatg ggagatgtac aaagtaaagt aatgatttcc
    17161 tcaaagcctc ctacaatttt aatgatggtt ggattgcaag gtgcaggtaa gactactaca
    17221 gcaggaaaac ttggaggata ttttaaaaag caaggtaaaa aacctctatt agtagcttgt
    17281 gatatttata gaccagcagc tataaagcaa cttcaagttg ttggagaaaa attggatata
    17341 cctgtattca atatgggaga taaagaaaat ccagtaaata ttgcgaaagc aggtttaagc
    17401 catgcgatta aaaatgctaa tgatttagtt attatagata cagctggtag acttcatata
    17461 gatgaagtac ttatggatga gttaaagtct attaaatcag aagttaagcc acatgagata
    17521 cttttggttg tagattctat gacaggtcaa gatgctgtaa atgttgcaga aagcttcaat
    17581 gaggcacttg gtgttgatgg agtagtatta actaaattgg atggagatac tagaggaggt
    17641 gctgcacttt caataagagc agttacacaa aagcctataa aatttatggg gatgggagaa
    17701 aagctagatg atatagaacc tttccaccca gatagaatgg catcaagaat attaggtatg
    17761 ggagatgtct taagtttaat agaaaaagca caagaaaata tagatttaga gaaagctaaa
    17821 gaattagagc aaaaaattaa aaaacaagag cttgattttg aagatttctt acaacaaatg
    17881 gaacaaatac aaaatatggg acctcttgac aagatacttg gtatgatacc tggtatggga
    17941 aatgtaaaag accaacttgg agatgtagat ttgaatggca aagaaatgaa gagaacaaaa
    18001 gccataattc agtcaatgac tacatatgag agaagaaacc caggagtatt aaatgcttca
    18061 agaaagaaaa gaatagctaa aggcagtgga actagtgtac aagatgtaaa tagacttata
    18121 aaacaactta atgaaatgaa aaaaatgatg aagatgtttg ctggttcaca aaagagtatg
    18181 aagaaaaggg gcggcttagg cggtttacct ttttttaaat aaaatataaa aaagtaaaaa
    18241 ttattcggag gtgactgtaa tggcagttaa aataagatta aaaagaatgg gagctaacaa
    18301 aaaacctttc tacagaatag tagtagctga ttcaagagct ccaagagatg gaaaatttat
    18361 agaagaaata ggatactata atccaatttc tgaacctaaa caagtaagaa taaatgatga
    18421 aaaagctata aaatggttag ctactggtgc tcagccaaca gaagtagtta aaaaattact
    18481 tgtaaaaaac ggagtaatag aaaaattcga agcttctaaa caagcaaaat aattttttct
    18541 tggcaattag tttaagtaag ggctcattgc taaggttact ttaggagatg aaatatatga
    18601 aagagctagt tgtagatata gctaaggctc tagttgataa tcctgactca gttgttgttg
    18661 aggaatttga agataatgat ggtatcgtct taaagcttac agttgctcaa gaggatatgg
    18721 gtaaggttat tgggaagcag ggaagaatag ctaaagctat aagaactgtc gtaagatctg
    18781 ttgcaaatag agaaaatata aaagtttctc ttgagatagt ataaaatagg aggattaggt
    18841 ataatgccta gtccttttta tataaatgcg tagtttaaga ttttatgatg atatgaccac
    18901 ataagattaa attttttaag aaggtgataa catgaaagaa aaattaactc attttaaggt
    18961 aggtcaaata gtaaatacac aaggtttaaa aggtgaagta agagtttatc cgcttactga
    19021 tgatatagag aggtttgatg aattaaaaga tttctatctg ggaaaagatt taaataataa
    19081 attggctgtt gaaaaagtaa gatacaaagg ttctatggtt ataatgaaga taaaaggcat
    19141 agacagcata gagaaagcag aaaaactaaa aaataaattt atgtatgtat ctagagaaga
    19201 tagcagagag cttgaagaag gcgaattttt tatagcagat atgattggaa tggaagtttt
    19261 aactgtagat ggaaaatatg taggaatact agaagatgtt cttcaatact cagcaaatga
    19321 tgtctatgta gtaaaaggtg aggaagataa agaatttatg ataccagcta taaaaaaatt
    19381 tgtacctaca atagatattg atgaaagaaa aatgattata gaccctatta agggaatgat
    19441 agattaggtg gtaatatgag atttcatata atgacacttt ttccagaaat atttaattcg
    19501 tacatggatg aaagtataat gaagagagca gttgaaaaag gtataattga ggttcatata
    19561 tataatataa gggatttttc taataataaa cataaaaaag tagatgatta tccatttgga
    19621 ggaggagcgg ggatggtaat gactcctcaa cctatatatg acacatataa gcatataata
    19681 acaactcata atataaataa cccaagtgta atttatctta ctccaaaagg taaggtatac
    19741 aatcaatcta tggcaaagca gatgtcttta aaagaagata taatactact atgtggtcat
    19801 tatgaaggaa tagatgagag aatcattgat ttaatagtta ctgatgaaat ttcaattgga
    19861 gattatgtat taactggggg agagctccca gcacttataa tgatagattc tatatcgaga
    19921 ttaataccag gtgtattaaa ccaagaagaa tcatttgaag aagaatcatt taaagacaac
    19981 ttattggaat atcctcatta cactagacct agagattttg aaggattaaa agtaccagaa
    20041 gtgcttttat cagggaatca taagaagata gatgagtgga gaagagaaga atctataagg
    20101 ataaccaaag aaagacgatt tgatttatat aaaaagtcta atgaaaaata aaaatataat
    20161 gaaaaattaa tatatatgta tacaataaag tacctataaa tggaattaaa aacataaaag
    20221 tgcttgtaat aactattgaa gtatagtata atataaaatg ttgaaaatac gggcgttcct
    20281 ctgtttacac tggtcgggta gttaagaacg tctatgatat ctaggaggaa gaaagatgaa
    20341 tgaaatgcta agagcaattg agcaagaaca attaaaaaat gaagttccta attttggacc
    20401 tggggacaca gttaaagtac acgttagaat tatagaagga aaaagagaaa gaatacaagt
    20461 attcgaaggt gtagtattaa agagacaagg tggaggagca agagaaactt tcacagttag
    20521 aaaaatgtct ttcaatgttg gtgtagaaag aactttccca gttcactctc caaaaataga
    20581 aaaaatagaa gttactagaa aaggtaaagt aagaagagct aaactaaact acttaagagg
    20641 tagagtaggt aaagctgcta agataaaaga agctagaaat aaataattaa aaactttact
    20701 tataaatggg gggctgattt atcagtcctc tttctatttt aatgaaaatt acaacaaata
    20761 attatactag aaataaatag aaatatttgt tgaaaatata gattatttat ctatgaattt
    20821 atagctttta aaatgaaaaa taaaattggt aaatattgca ttatattttg taacgatatt
    20881 aaaaataaga gaacagtatt atgtaaagta tgacgttaaa aagatgacaa tattatagtt
    20941 tgtgaagata tattttttaa gtggaattag gatataataa tataatatta ataaggagtg
    21001 atacatgtgt caaatgaata cgaagagtat cttatggatg acaatctaca tataaactgg
    21061 tatccaggtc atatgaaaaa aactaaggag ttagtaaaaa ataacttaaa attgattgat
    21121 gtagtaattg aacttttgga tgctagaatc ccgtttagta gtaaaaatcc agacatagac
    21181 aggcttgtag gagataagcc aagagttgtc gtacttaata agagtgatat ggcagatagg
    21241 gataaattga atcaatggat tgaatactat aagaaaatta atatcaaagc tataccagta
    21301 gatacaataa aaggtgttgg tataaataag ataatcgaag aatgtaaaaa tgtaactaga
    21361 gaaaaaatga gttctttaaa agacaaaggg agaaaagaaa gagctatacg aataatgata
    21421 gttggcgttc caaatgttgg taaatcgtct cttataaaca aattaacagg tagaaaaagc
    21481 actcaaactg gagataagcc aggagtaacg aaagggaaac aatgggttag attaaaggga
    21541 aatcttgaac ttttagatac gcctggaata ctttggccta agtttgaaga ccaagaagtt
    21601 gcattaaatt tagcatttag tagagctata aaggatgaga ttttagatac tgaaactttg
    21661 gctttaagac ttatagaaaa acttatgaaa atagaacctg agaagttgaa agccagatat
    21721 aagttagatt gtctaggaga aactccaatt gaaactatgg atatgattgg tcataaaaga
    21781 ggatttataa caggtaaaaa agaactagat tatacacgca tagccacaac tgtattaaat
    21841 gaatttagag atggaaaaat aggaaatata acattggaag ttccagaaaa cgttaaaaga
    21901 tagattttaa aacaaaatca aaaatttaat gttaaaaatt taaaaaagcc ttttagcaaa
    21961 ggctttttta tttttttgaa atatagacaa atatctccat ataaaagtat aaattaggtt
    22021 agaaagcctt taaaaatatt aatttaagac aaatatacct aatattttga aaattaaaat
    22081 gagtgtgatt attaaaaatt ttagcatatt gacttgcttg tttcgtataa tatataataa
    22141 gcacaaataa atacaatata ttaaaaattt aatttattta attttattaa tttaataata
    22201 agttcttatt gtttaattca acttacttat gcaagcgtaa acaatcgaga cattttatta
    22261 atttaataag gttaaaaagg gggattttat aatgggtaag accaaggatg ttatagtatt
    22321 tggatttgcg ttatttgcaa tgttctttgg agcaggtaac ttaatatttc caccttactt
    22381 gggaataatt acaggtccag aatggttaat tgccttctta ggatttacgt ttgctgatgc
    22441 tggattggca cttctagcag taatggctac agctaaattc gatggaaacg tagttgaaat
    22501 gtttaaaaga tgtggtatga agttagggat tcttataggt tgtgcagata ttttatgtat
    22561 aggaccattc ttagctatac caagaacagg tgcaacaact tatgaaatgg gtataatgcc
    22621 tttatttgga acttcaattc cagtgttatt attctgtata cttttttttg cgctttcata
    22681 tgtactaaca ataagacctt ctaaggtcgt agatatagtt ggacagtttt taactccagc
    22741 tcttttaata gctttagcat ttataattat aaaaggtatt atatcacctc ttggagatat
    22801 agtagataaa cctatgatac ctaatgtatt tgcagaaggt ataggtcaag gatatcagac
    22861 aatggatgct tttgcagcaa tagcacttgc atcagttcta atagtatctt taaatgataa
    22921 aggatattct actattagtg acaagttaaa aatgattggt aaggcgggtg ttcttgcttg
    22981 tggaggatta gctctagttt atggaggatt atgtttcctt ggagcaactg tatcaacaat
    23041 gtatggaaca gatgcagtac aatcacaagt aatagtaaat ataactgaag gattgcttgg
    23101 aaatgttggg aaagcgattt tagcagtagt agtatcatta gcatgtttaa ctacatctat
    23161 aggtcttaca tctgccacag gtcaatattt ctctagactt acaaaaggta agttgagtta
    23221 tgaaaaaata gtattagctg tatctgtatt cagtgcagta gtagcatctt ttggtgttgg
    23281 aactataata aagatagcat ctcctatatt aagtatagtt tatccaccat caattgtttt
    23341 aataatttta gctttcttca atgaaaaaat taagaatgat aatgtgtaca aaggagcagt
    23401 atatatgtca ttgcttgtaa gtatactaac agttatatct agttatggag tagctgttcc
    23461 agtagtaaac tctttacctc ttaattcatt aggatttaac tgggtggtgc ctgttataat
    23521 agctggaata attggcaatt ttataccatc aaagagtcaa tctaata
//
LOCUS       DAEPID010000061        22879 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.061, whole genome shotgun sequence.
ACCESSION   DAEPID010000061 DAEPID010000000
VERSION     DAEPID010000061.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 22879)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 22879)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..22879
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.061"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            21..3567
                     /locus_tag="KR257_002675"
                     /pseudo
     CDS             21..3567
                     /locus_tag="KR257_002675"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004453516.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="diguanylate cyclase"
     gene            3752..5686
                     /locus_tag="KR257_002676"
     CDS             3752..5686
                     /locus_tag="KR257_002676"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418706.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YgiQ family radical SAM protein"
                     /protein_id="HBH0031356.1"
                     /translation="MENKFLPISKQDMIDRGWEELDFVLVTGDAYVDHHSFGTAIISR
                     VLESAGYKVGIIAQPDWRTTDDFMKLGKPRLAFLVNAGNMDSMVNHYSVSKKHREKDM
                     YSPGGKMGYRPDRATIVYCNKIREAYSDVAIVIGGIEASLRRFAHYDYWSDKVRKSML
                     IDSGADLLVYGMSEKQIVEVANALNDGYDPKYIRHIDGTCYISDTLEEIYDKYILIPS
                     YKEICEDKMKYVEAFKIQYDEQDPFRGNIIVQPHGSKYLVQNKPEKPLSREELDEVYG
                     LPYQKTYHPVYEKFGGIPAIEEVKFSIVSSRGCFGSCSFCAITFHQGRAVQSRSEKSI
                     IDEAIGITNLDDFKGYIHDVGGPTANFRRPACKKQITKGACKNRQCLSPSPCKNLDAD
                     HSEYLHLLRAVRKLPKIKKVFVRSGIRYDYVMADKNNKFLRELIEHHVSGQLKVAPEH
                     ISEEVLKYMQKPAGKTYDKFRQKFFAINEELGKKQYLIPYLMSSHPGSTLNSAIELAE
                     YLRDTHYQPEQVQDFYPTPGTLSTTMFYTGIDPLTMKPVYVPKSKRDKAMQRALLQYR
                     APRNYDLVYSALVEAGREDLIGFGHRCLIKPKNEKPYFNRNNSKKNVSKGTNKNKKTN
                     TNNRSNKNQQKSSTKKKKKH"
     gene            5792..6787
                     /locus_tag="KR257_002677"
     CDS             5792..6787
                     /locus_tag="KR257_002677"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728699.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="HBH0031357.1"
                     /translation="MKKYISIILLVVLTMVVLVGCSPGKDNPKNKELSVVKQVKVAVP
                     DGLPAVAIAKLANENPEIKEGYETVYSIEKTPEAISTRVMKKDADIAIVPSNMAAIAY
                     NKTSSYNIVGTVGMGSLYLVSTENIKDYSDLVGKEVGCTGKGLTPDITIKSLLLQKDI
                     NYSDIKFNYVNSASELVPLLATGKVKTGIVPEPALSALMSKNPDIKIIKSLNDSWKEV
                     SGSKDGYPQSTLIVKSEFLRDNKDFVDSFVGQLSNSIDWANKNPEELGAYSEKIKIST
                     ESKIIGKSLERANLKYIPVKDMIKDYKNYYEKLANFDDKTLGGKVPDEAIYFVEK"
     gene            6759..7544
                     /locus_tag="KR257_002678"
     CDS             6759..7544
                     /locus_tag="KR257_002678"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418708.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease subunit"
                     /protein_id="HBH0031358.1"
                     /translation="MKQYTLLRNKKNKEQFIDKMEVTLSCVILLFLWQIIALKIDNDI
                     FLPTVGQVFNSIKEIMLNSSFYIDILYSMGRCFFSFLLAMIFAIILSIVSYLNRFFRN
                     LLKPINALTRSIPTMILVVLALIWFEKDSTPFIVGFTIVFPILYDNVLGAILNIDKNL
                     LEMANVYKIRFIDKVLKIYLPAIKFQIISILVSTFSLSLKVAIAGEVYSQPTYGIGTM
                     IQTEKINFNTSGIFAWIIIVLLISAILQIAQKFLARRAFLWKR"
     gene            7532..8230
                     /locus_tag="KR257_002679"
     CDS             7532..8230
                     /locus_tag="KR257_002679"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437066.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBH0031359.1"
                     /translation="MEKIKLSIENINKRYDSRIIFRDFNIDFYVNEVNCILGKSGCGK
                     TTLLNIISGIIKNDTNNLNIKENLNRVGNKLEASYIFQDDRLIDWLTVEENIKIVVNK
                     YYNKTQLNKICDEYLELVGISDYKKFYPQMLSGGIRQRVNIARAFIYPSKNIIMDEPF
                     KSIDAKNTQLIMDNFRNILRKEKRTVLFVTHNIEEALFLADRIFILGDSPIRIKKILK
                     NSKELEKNEVLKLI"
     gene            8353..8826
                     /gene="ybaK"
                     /locus_tag="KR257_002680"
     CDS             8353..8826
                     /gene="ybaK"
                     /locus_tag="KR257_002680"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418711.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Cys-tRNA(Pro) deacylase"
                     /protein_id="HBH0031360.1"
                     /translation="MVKTNAMRILDSNKIDYKVMSYEVKSEHVDGVEVAHDIGRDVNE
                     VYKTLVTQGVSKNIYVYVIPVHENLDLKKAAKVAKEKSVEMIHVKDINKLTGYIRGGC
                     SPIGMKKLYKTFVNESAKNLDTIIVSAGKIGYQIELSPFDLQRLIKVEFVDVIKK"
     gene            9023..9862
                     /locus_tag="KR257_002681"
     CDS             9023..9862
                     /locus_tag="KR257_002681"
                     /EC_number="4.2.1.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418713.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="fumarate hydratase"
                     /protein_id="HBH0031361.1"
                     /translation="MRKIKSEQIVEQVKKLCIEASLYLGEDVLSCIKEKAKSEKSEVG
                     KNILNILVENAEIAKEKNIPICQDTGMAVFFVEIGQEVLIEGDTLTDAINEGVRQGYE
                     EGYLRKSVVSPINRVNTKDNTPAVIHYDMVKGDKIKIEFAAKGFGSENMSKMKMLKPS
                     DGLEGIKKFIIDTVSEAGPNPCPPMVIGVGIGGTVDKCAQIAKKALFRELGEFNKDEN
                     IAKLESELLTAINKLGIGPQGLGGTTTALGLNIETFPTHIAGLPVVVNINCHASRHKK
                     VVI"
     gene            9875..10423
                     /locus_tag="KR257_002682"
     CDS             9875..10423
                     /locus_tag="KR257_002682"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418715.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Fe-S-containing hydro-lyase"
                     /protein_id="HBH0031362.1"
                     /translation="MIKITTPVNEIDIAKLNCGDTISLSGILYTARDAAHKRLIDCIN
                     KGEELPFDVYGQGIYYVGPTPTKPGEVIGAAGPTTSYRMDDLTIPLLERGLRLMIGKG
                     KRSDEVIEGMQKYGAVYLAAIGGAGAYISNSIKSCEIIAYEDLGAEAIRKIVVEDLKL
                     TVAIDSYGNNIYEQGRAIYECK"
     gene            10489..11670
                     /locus_tag="KR257_002683"
     CDS             10489..11670
                     /locus_tag="KR257_002683"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728698.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NADP-dependent malic enzyme"
                     /protein_id="HBH0031363.1"
                     /translation="MSKDYAKLALEMHEINKGKVSVESKVEVKTKDDLSTAYTPGVAE
                     PCLKIHENQDDVYRYTSKGNLVAVVSDGSAVLGLGNIGAEASIPVMEGKAILFKQFAD
                     VDAFPICLKTNDVDEIVKSVELMEPVFGGINLEDISSPRCFEIEERLKKSLSIPVFHD
                     DQHGTAIIVAAAIINSIKLIENKKIEDLEIVINGAGAAGIAIAKILLNMNVKNIILCD
                     RSGALEASIENLNYVQKEMLKVTNIRNEKGPLKDIIKGKDVFIGVSGPGAVTKEMVES
                     MSEKPIILAMANPAPEIMPEEAKLGGAFIMGTGRSDFPNQVNNVLAFPGIFRGALDVK
                     AKEINEEMKIAAAYAIANTISDEEICPEYILPDVFNKNVVKNVAKAVKEAAIKTKVNR
                     I"
     gene            11838..12224
                     /locus_tag="KR257_002684"
     CDS             11838..12224
                     /locus_tag="KR257_002684"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009248914.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HBH0031364.1"
                     /translation="MEYKVNDQELNASMFIPFVNRIWPGDYDTDKTQTALSKTLNITA
                     YDDKVLVGCLRVLSDGYYFGTITELLVLPEYQKQGIGSKLFQLAKENTPTMLYFGAQP
                     GVEEFYEKNGCQRSLQSYIIKKKDSY"
     gene            12374..12637
                     /locus_tag="KR257_002685"
     CDS             12374..12637
                     /locus_tag="KR257_002685"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418727.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="zinc ribbon domain-containing protein"
                     /protein_id="HBH0031365.1"
                     /translation="MEETKFCQCCAMPMGQTDELYGTNKDGSKSTDYCSYCFKDGEFT
                     ADISMEEMIEVCIPHMLQSNKDMTEDEARTMMNNFFPTLKRWK"
     gene            13163..13846
                     /locus_tag="KR257_002686"
     CDS             13163..13846
                     /locus_tag="KR257_002686"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004453504.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HBH0031366.1"
                     /translation="MSSILLVEDDLSLIYGLEFSIQKSGFSIDIARTVKEAMQMYEEK
                     NYDLLLLDVSLPDGNGFQICEKVREVSNIPIIFLTASDEEVNVVMGLDMGGDDYITKP
                     FKLNELISRIKALLRRYNVASNVNELSSNNITIKLLENRVFKGKFEVELTTAEYKLLC
                     LFMKNKNIVLTRKNILDKLWDGNGSFIDDNTLSVYVRRLRNKIEDNPENPKFLLTVRR
                     MGYKWNVIK"
     gene            13857..15098
                     /locus_tag="KR257_002687"
     CDS             13857..15098
                     /locus_tag="KR257_002687"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888761.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HAMP domain-containing histidine kinase"
                     /protein_id="HBH0031367.1"
                     /translation="MKIFSNKDIKIFFLMLISILVMFIIVGQIVVISITNNYKKTLIE
                     HDYNIAGYLYSIGVDKSKIPSAFVAHEDKYILKGKEILDTAGYGFDIDVSFTPSVKLF
                     QSKYIKTMSIYLLVFFTMIIFILYMYFFRQQSKIEEASYKIDLFMNGNINERLNTYEE
                     GSLSKLFSSIDVMSTSLNTHILKEKQSREFLKNTISDISHQLKTPLTALIMYNQILQE
                     ESHNSDVVEAFVQKSQSELERIETLIKNLLKITKIDSKTIILNKNNVNLKNLIVKILY
                     SFETRAEKEGKVISVNGSENTLLFCDYEWMSEALSNLIKNALDNTKENDKITIEWFET
                     TITTIVSVKDTGNGIHVEDIHHIFKRFYRSKFSKDNQGLGLGLPLVKSIVEQHNGTIS
                     VESKLSQGSIFTISFLKLTNM"
     gene            15170..15853
                     /locus_tag="KR257_002688"
     CDS             15170..15853
                     /locus_tag="KR257_002688"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002574824.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBH0031368.1"
                     /translation="MDILVVNNLCKTYGNGYTKVEALKDVSFTVSKGEFVTVVGESGS
                     GKSTLLNLLGGLDTPTSGRIFIDGKEICSMKEEKQTIFRRRNIGFIFQAYNLIPELTV
                     EQNIIFPLLLDYKKPDTIYLDEVLTILGLKDRKNHLPNQLSGGQQQRVAIGRALITKP
                     SIILADEPTGNLDSKNSNDVISLLKVTAEKYNQTIIMITHNTNIASTADRILQVSDGV
                     LTDLGVNRE"
     gene            15850..18180
                     /locus_tag="KR257_002689"
     CDS             15850..18180
                     /locus_tag="KR257_002689"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418734.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBH0031369.1"
                     /translation="MRSYLELVPQYAKVHKKKNRTTILCIIIAVCLVTAIFGLADMAI
                     QCQKIQFIKDDGNWHIVIRNIDEKFISEINSRVDIAHHGRGQVVDNGEFKSKEILIQG
                     LDEEVAKQFNLEIIRGRYPIGENETLIDEDAVKSFNLKIGDFIKIKLADGRNKNYKIV
                     GEYSSISSLRATDKHGLILSILGTQAIKKSETYDYYYITFKEKVNIRKATSDIKNTFN
                     LSDKQIGKNERLLSIIGQGDSDFSKPLYLTAGLLFVLVLVASIIMIYNSFNMSVIERV
                     KFFGLLRCLGSSKHQVKKFVVLESLILSIKAIPIGLVLGSLVTIISSIFLKYVNELFS
                     SMPILKVSFIGIAFGIIVGFLTVILSAIIPAKKASRVSPLSAVRGNLMSKEILNNGKT
                     SKVANIGSFKIETSMGLNHAFSRKKSFVLMTSSFAISIILFLGFSVLIDLMYQGLKPM
                     KPEAPHISIVDPNFKSVLTKEDINEISNIKGVKKVYSRMMTDIEATYNGKKTKSQLIS
                     YEKYQFNWAKKYLLKGEVNENKLQSENLALVEEGHGFDIGDKIYIKNGNAEKELEVGG
                     ILSSIPFEAKDKYIGNIITSENTFTNITGIKGYIIMDIQVDKDTPGDLIENIRRVVDD
                     NLEVRDKRQSNLEVKNSFYTMATFVYGFVFIIAIISMFNIINSMNISVTSRKNYYGVM
                     RAVGISNRQLRRMVIVEAGSYAVSGCLLGSILGLILHRYMFISLVSSMFHLEWQVPFN
                     LLLITVLTMIIITLLSVRKPIKKICELDIIDSINAQ"
     gene            complement(18361..19203)
                     /locus_tag="KR257_002690"
     CDS             complement(18361..19203)
                     /locus_tag="KR257_002690"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418736.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA-binding protein"
                     /protein_id="HBH0031370.1"
                     /translation="MINIGDFNKLTVKRKTEFGYFLDGQTNNTKDDILLHNRLIGKNE
                     INIGDEVNAFIFKDSDDRTAATLIPPLAKVGDVAHLKVVDNTDIGTFIDMGLPKDILV
                     PFKAKTYPLFRDEKYLFYIYLDKSKRIAATTDIDSYLLTDHTYNVGDIVTGVVYGFQT
                     NNSAMICVDNKYAGVILHNEYFTELKTGDVLENLHVIKIYEDGKLGLSPRGNRKDELD
                     TLENKILSYLEGSDGYMRFNDKSDPKDISILFNSSKKNFKRALGVLMKKGLIYQDEEG
                     TYLK"
     gene            19498..20232
                     /locus_tag="KR257_002691"
     CDS             19498..20232
                     /locus_tag="KR257_002691"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437044.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GntR family transcriptional regulator"
                     /protein_id="HBH0031371.1"
                     /translation="MKIVNKSSNIPLHTQLSSIIREMIETGELKEGDAIMPERELCNI
                     QNVSRMTVNKTIVGLVTEGLLYRVQGKGTFVAKQKKKYQFSNVKGFTDVMKEKGVNIK
                     TDILSFEMELPDDLVKRKLGISDNTTNIYKIVRLRYTDGEPFGLEIVYLSEEMCKGLT
                     KGILDNSSLYRVLNEKYGYKIQKAEQVMEPVILSDEESKLLETDEGALALKLHRNSYN
                     REGRPIEYTISIFRTDKYQYEIVLSE"
     gene            20242..21375
                     /gene="nagA"
                     /locus_tag="KR257_002692"
     CDS             20242..21375
                     /gene="nagA"
                     /locus_tag="KR257_002692"
                     /EC_number="3.5.1.25"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861065.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="N-acetylglucosamine-6-phosphate deacetylase"
                     /protein_id="HBH0031372.1"
                     /translation="MKCLINGKIILKNQILENKVLVFDEKIIDIADSVPKDCEVIDAD
                     GKYISPGLIDIHIHGNMGKDTMDSTDESIETISKSIMRHGVTSFLPTTMTMDKEHVYD
                     ALEVIKKAQNRKLEGAQVLGAHLEGPFINENYKGAQNEKFIINSKYEFIKEYKDVIKV
                     ITYAPEKDIDFDFTREIKRCTDIVLSIGHSNANYDQAKEAINLGVTNVTHMFNAMTGL
                     NHRDPGVVGAALTTNVYSELIADTIHINKDLFQFILNNKGKERLILITDSIEAGGLED
                     GNYSLGGQKVIVKGNEARLENGALAGSVLSLNKMVFNFLNNTNLKVNEAINLASLNPA
                     TSLGINDKKGSLEIGKDADIAVFDENLDCKMTLCLGEVVYKNI"
     gene            21474..22223
                     /gene="nagB"
                     /locus_tag="KR257_002693"
     CDS             21474..22223
                     /gene="nagB"
                     /locus_tag="KR257_002693"
                     /EC_number="3.5.99.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012425552.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glucosamine-6-phosphate deaminase"
                     /protein_id="HBH0031373.1"
                     /translation="MRVLVCKDYDGMSKKAAEMIAAQIVLKPNSILGLATGSTPVGMY
                     RDLVKKYNDNIVDFSDVMSFNLDEYYKLPISNDQSYDYFMKENLFNHVNIKPENTHLP
                     NGMADDIEKECMNYEASIDAAGGIDVQVLGIGRNAHIGFNEPDTKFAKRTHVVELTES
                     TIEANARFFKSREDVPKKAVSMGIGSILKSKKILLLASGEEKADAVYNTVYGDITPEV
                     PGSILQLHKDTIVIVDEAAASKLNPKDYKLV"
     gene            22375..22647
                     /locus_tag="KR257_002694"
     CDS             22375..22647
                     /locus_tag="KR257_002694"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0031374.1"
                     /translation="MLKIIMFSGILSSIIKLPIIGILPTGNIKKNTGISDSKKDGKQR
                     RSNLGISIYQLPSFLYSLINNSVPSNKPIPPEEIKLIKMYLLKSCI"
BASE COUNT         9101 a         2417 c         4015 g         7346 t
ORIGIN      
        1 tatacaatga ggatgtgagt atgatgaaca gactaaagcc aagaatttta ggtattagta
       61 tcttgtttat tattataatt attttaacat gtggagctgt tttcaagttt aaatttaaat
      121 tagataataa attaaaagaa accacacata catatttgtc tgagtttaca gaacacaata
      181 taattaatct caagacaaga cttagtggtc aatttgacat gcttgaatct attgctaact
      241 tcataggaaa cttgaataat ataaatgatg aaatggtgat tgatttaatg gattctgatg
      301 taaagcgaag ttctttaatt agaatgacta tctctacatt agatggggaa tgttattcta
      361 atgatggaat tacccataat gttcaagata gagattattt taaaaaagct aaaaatggag
      421 aaaagaatat atcagagcct ttaaaatcta ttgttaataa taaagaaata atagttttat
      481 ctaccccagt ttataaaagt gggaaaatag ttggtgtttt aagtggaatt tatgattcaa
      541 aaaagttaaa tgaattatta ggattatctg catttgatga aaaagcagat gtttttgttg
      601 caaagaaaaa tggagatata attgctcaaa aaacaaataa aaatagtaag acgatatcat
      661 gtatatttca gctttttgac aaagataatt gtgatgaagt tgattgtcta aaaactataa
      721 aagaaaatat gaaaaatgat aagtctgagt attttaatta taacttagat aatgaaaaat
      781 ttatgttaaa ctatcagcca cttggagtta atgattggta tgttttttct gttgtgccaa
      841 ataaaatagt gtctattcag tcagagaata tatcttatga tgtatatatt tttgcatgaa
      901 atactactag ttatattaat ttttataata tatatagcat gtattataaa taataacacc
      961 aaaattatta taaatgaaaa agaaaaattt aaagtactca ctgataatat actaggaggg
     1021 gttaaaacct gtttaaaaga tgaatatatg actatgacat atgtaagtca ggggttttta
     1081 gagcttacag gttactcttg tgaagattta aataaaatat ttaaaaatag atttaaagac
     1141 atgatttata aagatgattt agacaagttt aattgtatta ttctaaacca attagaaaaa
     1201 caagataaaa ttgaagttga atatagaatt gtaagaaaag atggaagtat aatttggatt
     1261 ttggagagaa gtaagtctat aaatgataat aaaggaagtg agtgtattca gggagtttta
     1321 actgatataa cagaatttaa gaaaatacaa gaagagttag attcaaaaag atttgaaata
     1381 caggctatca atgatagtat tgttggtgga atagtgataa ctgagataaa tgatgatttt
     1441 gatagtatat atttaaatga aggttattta aatatgattg gatatacacg caaacaactg
     1501 aaagatgagc taaataataa attaatcaaa cttattttta aagatgatag aacagaatta
     1561 attaatagta taaacaaaca actcaaatta agtgatacat ttgcatctga acaaagagtt
     1621 gaaaaaaggg atggcactat tatatggatt ttattaaaag gaagaaagat gatttatgat
     1681 aatggaaaat ctgtactttg ttgtgttatt gtagatatta cttctgctaa attattagag
     1741 caagaactta aaaagagtga agaacgtcat gaaatcattc taaagcagac gcaaaatatt
     1801 ataatagaat gggatataga aaaagataaa atgaatatat cacctaattg gtataataag
     1861 tttaaatatg accctataac tgaaaacgca acaaaaaata taattaaatc agtagatata
     1921 tatcatgatg atatggataa gtttatttca ttaattaaac ttacttcaca aggtagtgag
     1981 tatgaagagt gtgaaattag acttagaact agagatacta tttacgcttg gtttagtata
     2041 aaggcaacaa ctttatttga taataatggt aaaccttata aagtagtagg aagtttgact
     2101 gatattgatg aatcaaaacg agaagctgaa aagttgaaag aaagggcaga aaaagaccct
     2161 cttacagatt tgtataataa aaaagcatca caatcactta tagaagagta cataacattg
     2221 gataaaaaaa gaaaaggtgc tttaatgatt attgatattg atgactttaa aggaataaat
     2281 gataatttag gacatttata tggggatgct gtattaagtg aagttgcaaa tgacctaata
     2341 aatctattta gagcaaccga tatagtaggc agaattggtg gagatgagtt tattgtattt
     2401 ataaaagata tttctaaaac aagagatatt ataaataaag cagaagaatt ggtaaaaaca
     2461 tttgaaaggt cttttttagg taaaggacga aattataaaa tatcattaag tgtaggaatt
     2521 gctaagtttc cacaagatgg tatggactat atgacactat ttagaaatgc ggatatagct
     2581 ctttactcag ccaaagggaa gggcaagaat tgttatacat tgtatgataa aaaaattgat
     2641 aaagtccaat atataactaa tacaagaaat gcaggagata gtgataatgt agagatgtct
     2701 tttaaagaac atatcacaaa ttatatattt gatatactat atgaatcaag tgatatagaa
     2761 gtggcagtaa atttaattct aagtattgta ggtaaacact ttaatgtgag tcgcatgtat
     2821 atatttgaaa attcagatga taatcgagta tgtaaaaata catttgaatg gtgtaacgaa
     2881 ggtataacct cggaaattaa taatcttaaa aatatttgtt acaaggattt aggcaactat
     2941 cttttaaatt ttaatgcaga tgggttattt tattgtaatg atattgaaaa tttaggtagt
     3001 gatgtgaaaa aagtacttaa gccacaaggc atacgttcaa tattacaatg taaaatttta
     3061 gagggtaatg aatttagagg gttcatagga tttgatgaat gttcatataa tcgtatgtgg
     3121 actaatgatg aagtgaacac tttgacattt atatctaaaa cgctcaatat gtttttatta
     3181 aaaatgcgta ttcagagtaa gctagaagag tctttaacaa ttcaaaaatc tgtgatggat
     3241 aatatggata tatgggcata tgttgttgac aggaatacct atgaattact atttatcaat
     3301 aaaaaaatgc ttgagtcagc accaaacact catgtaggtg atttatgtta taaagcgata
     3361 tggaataatc aagataaacc ttgtaaaaaa tgccctatga tatatttaaa agatggtgat
     3421 gatacttata aatcattcat gcataataaa aagtttgagg tacaggcaaa tataactaca
     3481 actactttga aatggtttga tggtaaagat gcatgtttaa tatttggaag tgaaataact
     3541 agtattgaag ctgaagaaaa tacttaaaat actgtgttat atatatactt aaaatcgcaa
     3601 tttgaattta ttagacttaa aatgtctata taaatcattt aagttgtggt tttaagtatt
     3661 ttttatgata taattaagcg ttaagaacaa aattaaaaga tacttttgta taaaaaaata
     3721 tttgttaaat atatattgag caggtgataa tatggaaaat aagtttttac caataagcaa
     3781 acaagatatg atagatagag gatgggaaga attagatttt gttctagtta caggagatgc
     3841 ttatgtggac catcatagtt ttggaacagc aataatatct agagttttag aaagtgctgg
     3901 gtataaagtt ggaataatag ctcaaccaga ctggagaact acagatgatt ttatgaagct
     3961 aggaaaacct agacttgcat ttctagttaa tgcaggaaat atggattcaa tggtcaatca
     4021 ttattctgta agtaaaaagc atagagaaaa ggatatgtat tctccaggtg ggaaaatggg
     4081 ttatagacca gatagagcta ctatagtata ttgcaataaa ataagagaag catacagtga
     4141 tgttgcaata gtaataggtg gaattgaagc gagcttaaga agatttgcac actatgatta
     4201 ttggagtgat aaggttagaa agtctatgtt aatagatagt ggagcagatt tattagttta
     4261 tggtatgagt gaaaagcaga ttgtagaagt agccaatgca cttaatgatg gatatgaccc
     4321 aaaatacatt agacatattg atgggacatg ctatatttca gatacattgg aagaaatata
     4381 tgataaatat atattaattc catcatataa agaaatttgt gaagataaaa tgaagtatgt
     4441 agaagctttt aaaattcaat atgatgagca agacccattt agaggtaata taattgttca
     4501 acctcatgga agtaagtatc tggttcaaaa taagccagaa aaaccactta gtagagaaga
     4561 actagatgaa gtatatggat taccatatca gaagacatac catcctgtgt atgaaaaatt
     4621 tggaggaata ccagctatag aagaagtaaa atttagtata gtaagttcaa gaggctgttt
     4681 tggtagttgt tcattttgtg caataacatt tcatcaaggt agagcagtgc aaagtagaag
     4741 tgaaaaatca attattgatg aagcaatagg aataacaaat ttagatgatt ttaaagggta
     4801 tatacatgat gttggaggtc caacagctaa ttttagaaga ccagcatgta aaaaacaaat
     4861 tactaaaggt gcttgtaaaa atagacaatg cttatctcca tcaccatgta aaaatttaga
     4921 tgcagaccac agtgaatact tacatttact tagagctgta agaaaattac ctaaaataaa
     4981 aaaggtgttt gtgcgttctg gaattagata cgattatgta atggcagata agaacaataa
     5041 atttcttaga gagttgatag agcatcatgt aagtggtcag ttaaaggtag ccccagaaca
     5101 tatatcagaa gaagttttaa agtatatgca aaaaccagca ggaaaaactt atgataaatt
     5161 tagacagaaa ttttttgcta taaatgaaga attaggtaaa aagcagtatt tgatacccta
     5221 tttaatgtct agtcaccctg gttctacctt aaatagcgct atagagttag cagagtattt
     5281 aagagatact cactaccaac cagagcaggt tcaggatttt tatccaactc cagggactct
     5341 atctacaacc atgttttata caggtattga cccgcttaca atgaagccag tttatgttcc
     5401 taaatcaaaa cgtgacaagg caatgcaaag ggctttatta caatatagag cacctagaaa
     5461 ttatgatttg gtatactctg cgttagttga agcaggaaga gaagacttaa ttggttttgg
     5521 acatagatgt cttataaagc caaaaaatga aaagccttat tttaatagaa ataattctaa
     5581 aaaaaatgta tctaaaggaa caaataaaaa caaaaaaact aatacaaata acagaagtaa
     5641 taaaaatcaa caaaaaagtt caactaaaaa aaagaaaaaa cattaaagta taaataaaaa
     5701 tacttaaaaa agaaggatta ttcgataaat taacagaaat tagtataaat aaatataatt
     5761 attttaatga cgttaccttt gggaggaaga gatgaaaaag tatatttcta taatattatt
     5821 agtggtgttg actatggttg ttttggtagg atgttcacca ggaaaagata accctaaaaa
     5881 taaggagcta tcagttgtca aacaagtaaa agtagctgtt ccagatggac taccagcagt
     5941 ggcaatagct aaacttgcaa atgaaaatcc agagattaaa gaaggatatg aaacagtgta
     6001 tagcattgaa aagacacctg aagcgatttc cactagagtg atgaaaaaag atgcagatat
     6061 agctatagtt ccttcaaaca tggctgcaat agcgtataat aaaacttcat catataatat
     6121 tgttggaact gtaggaatgg gttcacttta tttggtgtca acagaaaata taaaagatta
     6181 ctctgattta gttggtaaag aagttggatg tactggaaaa ggacttactc cagacataac
     6241 tataaaaagt cttttgttac aaaaggatat aaattattca gatataaaat ttaattatgt
     6301 aaattcagca agtgaactgg taccattatt ggctactggt aaagttaaaa caggtattgt
     6361 tccagaacct gcacttagtg ctttgatgtc taaaaatcca gacataaaaa ttataaaaag
     6421 tttaaatgac tcatggaagg aagtaagtgg ttcaaaagat ggttatcctc aatctacttt
     6481 aattgtaaag tctgaatttt taagagataa taaagatttt gttgattctt ttgtaggtca
     6541 attatcaaat agtatagatt gggcaaacaa aaatcctgaa gaattaggtg catattctga
     6601 aaaaataaaa atatctactg aatcaaagat aataggaaaa tctcttgaaa gagctaattt
     6661 gaaatatatt ccagttaagg acatgattaa agattataaa aattactatg agaaattagc
     6721 taattttgat gataagacat taggaggcaa agtaccagat gaagcaatat actttgttga
     6781 gaaataaaaa aaataaagaa caatttatag ataaaatgga ggtaacactt tcttgtgtta
     6841 tcctcttatt tttatggcaa attattgctt taaaaattga taatgatatt tttttaccaa
     6901 cagtaggtca agtgtttaat agtataaaag agattatgct aaattctagt ttctatatag
     6961 atatacttta ctctatgggg agatgttttt ttagtttttt actggctatg atttttgcta
     7021 ttatactttc aatagtgtct tatttaaata gattttttag aaacttatta aagccaatca
     7081 atgctttgac acgttcaata ccaactatga tattggtagt acttgcactt atttggtttg
     7141 aaaaggatag tacccctttt atagttggat ttactatagt ttttcctata ttgtatgata
     7201 acgttttggg cgctatattg aatatagaca agaacttatt agaaatggct aatgtgtata
     7261 aaataaggtt tatagataag gtgttaaaaa tttatttacc agccataaaa tttcaaatta
     7321 tatctatact agtatcaaca ttctctttaa gtttgaaagt tgctatagca ggagaggtat
     7381 atagtcaacc tacatatggt attggaacta tgatacagac tgaaaaaatt aactttaaca
     7441 catctggaat atttgcatgg ataattattg ttcttttaat atctgctatt ttacaaatag
     7501 ctcaaaagtt tttagcaagg agagcttttt tatggaaaag ataaagttga gtattgaaaa
     7561 tataaataaa agatatgata gtcgtattat atttagagat tttaatattg atttttatgt
     7621 aaatgaggta aattgtatcc ttggaaaatc tggttgtgga aaaactacac tcttgaacat
     7681 aataagtggg attattaaaa atgacaccaa caatctaaat atcaaagaaa atttaaatag
     7741 agtaggaaat aagcttgaag ctagttacat atttcaagat gatagactta tagactggtt
     7801 aacagtagaa gaaaatataa agatagttgt aaataaatac tataataaaa ctcaattaaa
     7861 taaaatttgt gatgaatact tggaattggt tggaattagt gattataaaa aattctatcc
     7921 tcaaatgctt agtggaggta ttagacaaag agtaaatatt gctagagctt ttatatatcc
     7981 atcaaaaaac attataatgg atgaaccttt taaatctatt gatgcaaaga atacacagct
     8041 tataatggat aatttcagaa atatattaag aaaagaaaag agaactgtgt tatttgtaac
     8101 tcataatatt gaggaagcat tgtttttagc agataggata tttattttag gagactctcc
     8161 aattagaata aaaaaaatat taaaaaattc taaggaattg gaaaaaaatg aagttttgaa
     8221 gttgatatag agttataata atactgtcgt tttaaaatat atttggttaa aatctataag
     8281 actatattaa aatagtacag aatattcaaa actgtgtata atgttcgtat tttataaaaa
     8341 ggaagtgaat gtatggttaa gactaatgct atgagaatat tagattcaaa taagattgat
     8401 tataaagtaa tgtcttatga agtgaaaagt gaacatgtgg atggtgttga ggtggcacat
     8461 gatataggaa gagatgtaaa tgaagtgtat aagacattag taactcaagg agttagtaag
     8521 aatatatatg tatatgtaat accagtacat gaaaacttag acttaaaaaa ggctgcaaaa
     8581 gtagctaaag agaaaagtgt agagatgatt catgtaaaag atataaataa gcttacaggt
     8641 tatattagag gcggatgttc tcctataggt atgaaaaagc tttataaaac ttttgtaaat
     8701 gaaagtgcaa agaatttaga tacaattatt gtgagtgcag gaaaaatagg atatcaaata
     8761 gaactatctc catttgattt acaaagactt ataaaagtag aatttgtaga tgtaataaaa
     8821 aaataagaat tacatataaa atatagagct tatattctca ataataggtg ttgtaatatt
     8881 aataaaatga ataataattt taaaataaat attcagttac ttatgtgtaa ttggtataaa
     8941 aatattgaga aattttaaaa acaatggtaa agtgtaagta taatcacgaa tattttttat
     9001 aaagtaatgg agggatgttc gcttgagaaa aataaaatct gaacaaatcg tcgagcaggt
     9061 aaaaaaactt tgtatagaag cgagcctata tttaggagaa gatgttttaa gttgtataaa
     9121 agaaaaagcg aaaagcgaaa agagtgaagt tggaaaaaat atattgaata tattagttga
     9181 aaatgctgaa atagctaaag aaaaaaatat accaatatgc caagatactg gtatggctgt
     9241 attttttgtt gaaataggac aagaagtttt aattgaagga gacacactta ctgatgctat
     9301 aaatgaggga gtaagacaag ggtatgaaga aggctactta agaaaatctg ttgtaagtcc
     9361 aattaacaga gtaaatacaa aagataatac acctgctgtt attcattatg atatggtaaa
     9421 aggtgataaa attaaaatag aatttgcagc taagggattt ggaagcgaaa atatgagtaa
     9481 gatgaaaatg ttaaagccat cagatggatt ggaaggaatt aaaaaattca taatagatac
     9541 agtttcagaa gctggaccta acccatgccc tcctatggta attggagttg gtataggtgg
     9601 gactgtggac aaatgtgctc aaatagctaa aaaggcactt tttagagaac taggtgaatt
     9661 taataaggac gaaaatatag caaaacttga aagtgaacta ttaacagcta ttaataaact
     9721 tggtatagga cctcaaggct taggtggtac tacaacagct ttgggattaa acatagagac
     9781 ttttcctaca cacatagcag gtctacctgt tgttgtaaat ataaactgcc atgcatcaag
     9841 acataagaag gtagtaattt aggaggaaaa taaaatgata aaaataacta cacctgtaaa
     9901 tgaaattgat atagcaaaat taaattgtgg agatacaatt agtttgagtg gtatacttta
     9961 tacagcaaga gatgctgctc ataaaagatt gatagattgt ataaataaag gtgaagaatt
    10021 accatttgac gtatatggtc aaggaatata ttatgtagga cctactccta caaagccagg
    10081 agaagttata ggtgctgcag gtccaacgac gagttataga atggatgatt tgactatacc
    10141 tcttttagaa agaggtctta gattgatgat aggcaaggga aaaagaagtg atgaagttat
    10201 agaaggtatg caaaaatacg gagcagttta tcttgctgca ataggaggag ctggagcgta
    10261 tatttcaaat tcaataaaat catgtgaaat tattgcatat gaagatttag gagctgaagc
    10321 tataagaaag attgtagtag aagaccttaa gcttacagta gcaatagata gctatgggaa
    10381 taatatatat gagcaaggtc gagcaattta tgaatgtaaa taatgtttag aaataaatat
    10441 gaatatcaaa attaaaaata gttgtgtata ttttaaggag gaaaattgat gtctaaggat
    10501 tatgcaaaat tggcattaga aatgcatgaa atcaacaaag ggaaagtaag tgtagaaagc
    10561 aaggtagaag ttaaaactaa ggatgattta tcaacagcat atacaccagg ggttgcagaa
    10621 ccttgtttaa aaatacatga aaatcaagat gatgtttata gatacacttc taaagggaat
    10681 ctagtagcag tagttagtga tggaagtgct gtacttggat taggtaacat tggtgctgaa
    10741 gcatctatac ctgttatgga aggtaaagct atattgttta aacaatttgc agatgtagac
    10801 gcttttccaa tatgtttaaa gactaatgat gtagatgaga tagttaaatc tgtagagttg
    10861 atggaacctg tatttggagg tataaatttg gaagacatat cttctccaag atgttttgag
    10921 atagaagaga gattaaaaaa atctttaagt atacctgttt ttcatgatga ccaacatggg
    10981 acagcaataa tagttgcagc agccataata aactcaataa agttaattga aaataaaaaa
    11041 atagaagatt tagaaatagt tataaacgga gcaggagctg ctggtatagc catagcaaag
    11101 atactactta atatgaatgt taaaaatata atcttatgtg atagaagtgg agcattggaa
    11161 gctagtatag aaaatctaaa ctatgttcaa aaagaaatgt taaaagtaac aaatataaga
    11221 aatgaaaaag gacctttaaa agatattata aaaggaaaag atgtatttat tggtgtttca
    11281 ggtccaggag ctgttacaaa ggaaatggtt gaaagtatgt ctgagaagcc aataatattg
    11341 gcaatggcaa atcctgctcc agagataatg ccagaagaag caaaattagg tggagcattt
    11401 ataatgggaa caggtcgttc agacttccct aatcaagtca ataatgtatt ggcttttcct
    11461 ggaatattta gaggagcatt agatgttaag gctaaagaga taaatgaaga aatgaagata
    11521 gctgctgcat atgcaattgc taatacaata agtgatgagg aaatatgccc agagtatata
    11581 ttaccagatg tatttaataa gaatgtagta aaaaatgttg ctaaggcagt taaagaagca
    11641 gctataaaaa ctaaagtaaa tagaatataa atttttatat gctcatatat tcttactttt
    11701 atatacatat ctttatgatt aaacgtgtta gaaaacgtag taaatttata ctatcagact
    11761 ttacctttat tacttaaaat gatataatat gaatattata aattaataaa tttaaattta
    11821 ttgaggtgca agagataatg gaatataaag ttaatgacca agaacttaat gcttcaatgt
    11881 ttatcccatt cgttaacagg atatggccag gagattatga tacggataaa acacagactg
    11941 cattatcaaa aactttgaat ataactgctt atgatgataa agtgcttgta ggatgtctgc
    12001 gagttctttc agatggttat tattttggaa caattacaga attgcttgtt cttccagagt
    12061 atcagaaaca aggcattggt agtaagcttt tccagcttgc taaagagaat acaccaacta
    12121 tgctatattt tggtgcacag ccaggagtag aagagttcta tgaaaaaaat ggatgccaaa
    12181 gaagtcttca atcttacata ataaaaaaga aagatagtta ttaaagttcc agctttcaat
    12241 aatcttaaaa gtacaatatt ttagtggaat catttcattt tttattacta atatgacata
    12301 aacatgtcat attagtattg atatactttt aatatggtta agagccaaag aaaaatataa
    12361 ggagtgattt aaaatggaag aaactaaatt ttgccaatgc tgtgcaatgc caatgggaca
    12421 aactgatgaa ttatatggga caaataaaga tggaagtaaa agtactgatt attgtagtta
    12481 ttgttttaaa gatggtgagt ttacagctga tataagtatg gaagagatga tagaagtttg
    12541 tatccctcat atgcttcaaa gtaataagga tatgactgaa gatgaagcaa gaacaatgat
    12601 gaacaatttc tttccaacat taaaacgctg gaaataattt tatgcaaaat tagttatatg
    12661 caaaacatga aatatggtgt tgagaataag gggtggtgtg ctttatagca taccacctgt
    12721 tttgttactt gctagttcag gtattcttgt atgcttaaat atgttctcat ctctctttct
    12781 attttaaatt gtaaaaatct aaaatatgtt atttatattc tacttcttta tccatgtctt
    12841 tttctaccac aagtcaaatc caactacaaa atcatcattt tcaattcact gtttaataga
    12901 attaacagat aaagagttat aaaattttct attttttata taaaataata caggtcaagc
    12961 tgacttctag ctacttggga tagtgtatat atttatgata gttataggag taataccaat
    13021 cattagactg ttgatttgtg tagtcttttg taaaaacatt tgttttaata tattgagttt
    13081 ttgaaaaagt aaaattataa ttataataaa ttaagtgtaa taatgtatta gaagtaaaaa
    13141 taattaaaat agaggtgatt aaatgagtag tatattgtta gttgaagatg atttaagctt
    13201 gatatatgga ttagagttct ctatacaaaa aagtggattt agtatagaca tagcaaggac
    13261 agtaaaagaa gctatgcaaa tgtatgagga aaaaaattat gacttattgc ttttagatgt
    13321 atccctacct gatggtaatg gatttcagat ttgcgaaaaa gtacgagagg tttctaatat
    13381 acccattata tttttgactg cttcagatga agaggtaaat gtagtgatgg gtcttgatat
    13441 gggtggagac gattatataa caaaaccttt taaattaaat gaattaattt caagaataaa
    13501 agcattactt agacgttata atgttgcaag taatgtgaat gaattaagtt caaataatat
    13561 tactattaaa ttacttgaaa atcgtgtttt taaaggtaaa tttgaggtgg aacttaccac
    13621 agcagaatat aaattattgt gcttatttat gaaaaataaa aatattgtac ttactagaaa
    13681 aaacatattg gacaagttat gggatggaaa tggtagcttt atagatgaca atacattatc
    13741 agtatatgta agacgattga gaaataaaat tgaagataat cctgaaaatc ctaagtttct
    13801 attgaccgtt agaagaatgg gttataagtg gaatgtaatt aagtgagggt attaatatga
    13861 agatattttc taataaagat ataaaaatat tttttttaat gcttatatct attttagtaa
    13921 tgtttattat agtagggcaa atagtggtta taagtataac taacaattat aaaaaaacgt
    13981 tgatagagca tgattataat atagctggat acttatatag tataggtgtt gataaatcta
    14041 aaataccatc agcatttgtt gcacatgaag ataaatatat tttaaaagga aaagaaatac
    14101 tagatacagc tggatatgga tttgatatag atgttagctt tacaccaagt gtaaaattgt
    14161 ttcaaagtaa atatataaaa actatgtcta tctatttatt agtatttttt actatgatta
    14221 tttttatact atatatgtat ttttttaggc aacaaagtaa gatagaagag gctagttata
    14281 aaattgattt atttatgaat ggaaatataa atgaaagact aaatacatat gaagaaggta
    14341 gcttatcaaa attatttagt tcaatagatg ttatgtcgac atctttaaat acacatatat
    14401 taaaagaaaa acagagcaga gaatttctta aaaatacaat ttcggatata tcgcatcaat
    14461 taaaaactcc acttacagct ttaataatgt acaatcagat actacaagaa gaaagtcata
    14521 atagtgatgt cgttgaagct tttgtacaaa aaagtcaaag tgaactagaa cgcattgaaa
    14581 cattgattaa gaatttatta aagattacaa agatagattc aaaaacaata attctcaata
    14641 aaaataacgt taatcttaaa aatttaattg tcaaaatttt gtatagcttt gaaactaggg
    14701 cagaaaaaga aggaaaggtt atttctgtaa atggttcaga aaatacattg ttgttctgcg
    14761 attatgaatg gatgtcagag gctttaagta atcttataaa gaatgcatta gataatacaa
    14821 aagagaatga taaaataacg atagagtggt ttgagacgac tataaccacc attgtttcag
    14881 ttaaagatac tggaaatgga atccatgttg aggatattca tcatatattt aaaaggtttt
    14941 atagaagtaa gttttcaaaa gataatcaag gtttaggact gggattacca ctagttaaat
    15001 ctattgtgga acaacataat ggtactattt ctgtagaaag taaactatca caaggaagta
    15061 tattcaccat aagtttttta aagcttacta atatgtaaga taaaatacat cttgcagtaa
    15121 ggtatataga ttattattat attaatcaat tagaaaggtg agagagaaaa tggatattct
    15181 tgtggttaat aatttatgta aaacatatgg aaatggatat acaaaggtag aggcattgaa
    15241 agatgtatcc tttacagttt caaaaggaga gtttgtgact gtagttggag aatctggttc
    15301 aggaaagagt acactattaa atctcttagg aggtcttgat actccaacat cagggagaat
    15361 atttattgat ggtaaagaaa tatgttcaat gaaagaggaa aaacagacta tttttagacg
    15421 tcgtaacata gggtttatat ttcaggcata taaccttata ccagaactaa ctgtggagca
    15481 aaatataata ttcccattgt tattagatta taaaaaacca gatactattt acttagatga
    15541 agtattgact attttaggtc ttaaagatag gaaaaatcat cttccaaatc aattatctgg
    15601 tggtcaacaa cagagagttg caattggaag ggctttgatt acaaagccaa gtattatact
    15661 ggcagatgag ccaacgggaa atcttgacag taaaaatagt aatgatgtaa tttcactttt
    15721 aaaagtgact gcagaaaagt ataatcaaac cattattatg ataactcata atacgaatat
    15781 agcttctaca gcagatagaa tactacaggt ttctgatggt gtgcttacag acctgggggt
    15841 gaatagagaa tgagaagcta cttagaatta gtaccacaat atgcaaaagt acataagaaa
    15901 aaaaatagaa ctacaatttt atgtattatt attgcagtat gcttagttac tgctatcttt
    15961 ggacttgcag atatggctat acaatgtcaa aagatacaat ttattaaaga tgatggaaat
    16021 tggcacatag taattagaaa tattgatgaa aagtttatat cagaaataaa tagtagagta
    16081 gatatagctc accatggtag ggggcaagtc gttgacaatg gagagtttaa atcaaaggag
    16141 attttgatac aaggtttaga tgaagaagta gcaaagcaat ttaacttaga aataataagg
    16201 ggtcgttatc ctattgggga gaatgagact ttaatagatg aggatgcagt taaaagcttt
    16261 aatctaaaaa taggagattt tatcaaaata aaattagcag atggtagaaa taaaaattat
    16321 aagatagtag gtgaatattc atcaatatca agcttaagag ctacagataa acatggatta
    16381 atactttcaa tattgggtac acaagctatt aaaaaatcag aaacgtacga ttattattat
    16441 attacattta aagaaaaggt taatattaga aaagccactt ctgatattaa aaataccttc
    16501 aatttaagtg ataaacaaat tggtaaaaat gaaagattac tttctattat aggtcaaggt
    16561 gactctgact tttctaaacc attgtattta acagcaggat tactttttgt acttgtttta
    16621 gtagcaagta ttatcatgat atataatagt tttaacatga gtgtaattga gagagttaaa
    16681 ttttttggtc tgttacgttg tctagggtca tcaaaacatc aagttaaaaa atttgttgtt
    16741 ttagaaagtt taattttaag tataaaagct attccaatag gcttagtatt aggaagtctt
    16801 gtaactatta tatcttctat atttcttaag tatgttaatg agttattcag ctcaatgcca
    16861 attttaaaag ttagttttat tggtattgca tttggaataa ttgtagggtt tttaactgta
    16921 atattatcag ctattattcc agcaaaaaaa gcttcccgtg tatctccact tagcgctgta
    16981 cgtgggaatc taatgtccaa agaaatttta aataacggga agacaagtaa agttgcaaat
    17041 ataggaagtt ttaaaattga gacttctatg ggattaaatc atgctttttc aagaaagaaa
    17101 tcttttgtac ttatgacttc ttcatttgcc attagtatta tactattttt aggttttagt
    17161 gtgcttatag accttatgta tcaaggactt aagcctatga agccagaagc tcctcatata
    17221 tctattgttg accctaattt taagtctgtt ttaactaagg aagatattaa tgaaataagc
    17281 aatatcaaag gagtaaagaa agtatacagt agaatgatga cggatataga agctacatat
    17341 aatgggaaga agacaaaatc acaattaatt tcttatgaaa agtatcaatt taattgggca
    17401 aaaaaatatc tattaaaagg agaagttaat gaaaataaac tacagtcaga aaaccttgca
    17461 ttagtagaag aggggcatgg atttgatata ggagataaga tatatattaa aaatggaaat
    17521 gctgaaaaag agttagaggt aggaggtata ctttcctcaa ttccatttga ggctaaagat
    17581 aaatatattg gaaatattat aacatctgaa aatactttta cgaatataac aggtataaag
    17641 ggttatataa taatggatat tcaggttgat aaagatactc ctggagattt aattgaaaat
    17701 ataagacgtg tagtagatga taacttagag gtcagagata aaagacaaag taacttagag
    17761 gttaaaaatt cgttttatac tatggcaaca tttgtatatg gatttgtgtt tattattgcg
    17821 attataagca tgtttaatat cataaatagc atgaatataa gtgttacaag tagaaagaat
    17881 tactatggtg ttatgcgtgc agttggcata tccaacagac aattaagaag aatggtaata
    17941 gtagaggcag gttcatatgc agtgagtggt tgtttattag gtagtatact aggattaata
    18001 ttacataggt atatgtttat atcgttagta agctcaatgt ttcatttaga gtggcaagta
    18061 ccttttaatt tactacttat cactgtacta actatgataa taataacttt attatcagta
    18121 agaaaaccaa tcaaaaagat ttgtgaatta gatataatag actcaataaa tgcacaataa
    18181 atataggtat tgatttaaat taaaaaaacg aagtaaaaat gaaatagaaa atatttttca
    18241 tttttacttc gttttttata ttataaaatt tttgttatgt tacaaaattt ctataaagat
    18301 gatgtgaatc taaacattat atgacaacgt gagcatttaa gttaaaatat tttaaatata
    18361 ctattttaga taagttccct cttcatcttg ataaattaat ccttttttca taagcactcc
    18421 aagagctcgt ttaaaatttt tcttacttga attaaataat atagaaatat ctttagggtc
    18481 agatttatca ttaaatctca tatatccatc agaaccttct aaataactta aaatcttatt
    18541 ttctaaagta tcaagttcat cctttctatt tcctctagga gaaagaccaa gttttccatc
    18601 ttcatatatt tttatgacat gtaaattttc aagaacatca ccagttttta gttcagtaaa
    18661 gtactcatta tgaagtatta caccagcata tttattgtct acacatatca ttgcagaatt
    18721 attagtttgg aatccatata caactccagt tacaatatct cctacattgt aagtatggtc
    18781 tgttaataag tatgaatcta tatctgtagt agcagcaatt cttttgcttt tgtctaaata
    18841 tatataaaat aaatattttt cgtctctaaa tagtggataa gtcttagctt taaaaggaac
    18901 taatatgtct ttaggaagtc ccatatctat aaaagtacca atgtctgtat tatcaactac
    18961 ttttaaatgt gctacatccc caaccttagc taaaggcggt attaaagttg cagcagttct
    19021 gtcatcagaa tctttaaata tgaaagcatt tacttcatca cctatgttta tttcattttt
    19081 tccgattaat ctattatgaa gaagtatatc gtcttttgtg ttattagttt gtccatccaa
    19141 aaaatatcca aattcagttt ttctttttac tgtaagttta ttaaaatcac ctatgtttat
    19201 caaattaaaa tcatcctctc attttatatt tataatttag ccataatata cttatgtagt
    19261 agtttgtcac agtatctata ttagtattag tgaaatttac aataaataat atagttattt
    19321 atgtattttt caattctcta gcttcttata tagtataaac tccaatttct tttttgtctt
    19381 taggttttat taaaattttt acaaaataag ttaaaaagta ttgaaataaa atttctttta
    19441 aagtataatt ggtatatacc aaaattggta tataccatat cgaaaagtgg tgactatatg
    19501 aaaatagtaa ataaatctag taatatacca ttgcatactc aattaagttc aataataaga
    19561 gagatgatag aaactggtga gcttaaagag ggcgatgcaa taatgccaga aagagaactt
    19621 tgcaacatac aaaatgtaag tcgtatgaca gtaaataaaa ccattgttgg attagttaca
    19681 gaaggacttc tttatagggt acaaggtaaa gggacattcg ttgcaaagca aaaaaagaag
    19741 tatcagtttt caaatgtaaa aggttttact gatgttatga aagaaaaggg agtaaacata
    19801 aaaacggata tattatcctt tgagatggaa ctaccagatg atttagttaa aagaaagctt
    19861 ggaataagtg ataatactac aaatatatat aagattgtca gacttagata tactgatgga
    19921 gagccatttg gattagaaat agtatatcta tcagaagaaa tgtgtaaggg tctaacaaaa
    19981 gggatattgg ataattcttc attatatagg gttttaaatg aaaaatatgg ctataagata
    20041 caaaaagctg aacaggtaat ggagccagta atactttcag atgaagaaag taagcttctt
    20101 gaaacagatg aaggtgcttt agctcttaaa cttcatagaa attcctataa tagagaaggt
    20161 agacctatag aatataccat atcaatattt agaacagata aatatcaata tgaaatagta
    20221 ttgagtgagt aggtgaataa tatgaaatgt ttaattaatg gaaagataat attaaaaaat
    20281 caaatcttag aaaataaagt attagtattt gatgaaaaaa taattgatat agctgatagt
    20341 gtaccaaaag attgtgaagt tatagatgct gatggaaaat atatatctcc agggcttatt
    20401 gatattcata tacatggaaa catgggaaaa gatacaatgg attcgactga tgaatctatt
    20461 gaaacaattt caaaatcaat tatgagacat ggagtaacat cttttcttcc aactacaatg
    20521 actatggata aagaacatgt ttatgatgca cttgaagtta ttaaaaaagc ccaaaataga
    20581 aagcttgaag gggcacaagt attaggagca catttagaag gaccttttat aaatgagaat
    20641 tataagggag cacaaaatga aaaatttata ataaattcaa aatacgaatt tataaaagaa
    20701 tataaagatg ttataaaagt tataacttat gctccagaaa aagatattga ttttgatttt
    20761 actagagaaa taaaaagatg tacagatata gttttatcta ttggtcatag taatgcaaat
    20821 tatgaccaag ctaaagaagc tataaattta ggagtaacta atgtaactca catgttcaat
    20881 gcaatgactg gtttaaacca tagagaccca ggcgttgttg gtgcagcact tacaactaat
    20941 gtgtacagtg agttaatagc agatacaatc catataaata aagatttatt tcaatttata
    21001 ctaaataata aaggaaaaga aagactgatt ttaataacag attctataga agctggtggt
    21061 cttgaagatg gcaattattc tcttggaggt cagaaagtca tagttaaggg taatgaagct
    21121 agacttgaaa atggagcatt agctggaagt gtgttgtctt taaataaaat ggtatttaac
    21181 ttcttaaata atacaaacct taaagtgaat gaagcaatta atttagcttc tttaaatcca
    21241 gcaacatctt tgggaataaa tgacaaaaaa ggaagcttag aaataggtaa ggatgcagat
    21301 atagctgtat ttgatgagaa tttagattgt aaaatgacac tttgcttggg ggaagtagta
    21361 tataaaaata tatagtatac aaaacaaacc ttaaagacag taaaaacaat ataaaaaata
    21421 ataaattaaa cttacattag taaaagtagt agttaaaatt taggaggaat aagatgagag
    21481 tattagtgtg taaagattat gatggaatga gtaaaaaagc cgctgaaatg atagcagctc
    21541 aaatagtttt aaaaccaaat tcaatactgg gactagctac aggaagtaca ccagtaggta
    21601 tgtatagaga tttagtaaaa aaatacaatg ataatatagt agatttttca gatgtgatga
    21661 gctttaattt agatgaatat tataagttac caatatctaa tgaccaaagc tatgattatt
    21721 ttatgaaaga gaatctattt aatcatgtaa acataaagcc agaaaatact catctaccaa
    21781 atggaatggc tgatgatatt gaaaaagagt gtatgaacta tgaagcttct atagatgcag
    21841 ctggtggtat agatgtacaa gtacttggaa taggtcgtaa tgctcatata ggttttaatg
    21901 aacctgatac taaatttgca aaaagaactc atgtagttga acttacagaa tctacaatag
    21961 aagctaatgc aagattcttt aaatcaagag aagatgttcc taaaaaagct gtaagtatgg
    22021 gaataggttc aatattgaag tctaagaaaa tattgctttt agcttcagga gaagaaaaag
    22081 ctgatgcagt atataatact gtttacggag atataactcc agaagttcct ggttctatac
    22141 ttcaacttca taaagacact atagttatag tagatgaagc agcagcaagt aaattgaatc
    22201 caaaagatta taaattagta taagaataga atgtagttta aataaaaaat agctatcatt
    22261 gaataatcaa atttatttaa tgatagctat ttttatttaa attagttatt attgtttaaa
    22321 ttacttgctt attacttttt acgaaaactc gttatcaaga agtatccaaa taagatgtta
    22381 aaaattatta tgtttagtgg gattctatca agcataataa aattacctat aattgggata
    22441 ttaccaactg gaaacataaa gaagaataca ggcatcagtg atagtaaaaa agatggaaaa
    22501 caaagaagaa gtaatcttgg aatatcaata taccaactac catccttttt gtattctcta
    22561 atcaataatt cagttcctag taataaacca ataccaccag aggaaattaa attaataaaa
    22621 atgtatcttt taaagtcttg catataacca gtgtaaaatt gagtatagaa atcataattt
    22681 aatttaacgg ctaaaaaata cataagcaat agaatgatta aaaataaaag atatctaaga
    22741 gcttttttca ttttaaattc tcccttcaga aatactttat ttagttttat tttgttggaa
    22801 tctgatttta tcatttagtt taagaaatcc ataatattag tgaagaatga aataagtatt
    22861 atatatgaat aaatatttt
//
LOCUS       DAEPID010000062        22313 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.062, whole genome shotgun sequence.
ACCESSION   DAEPID010000062 DAEPID010000000
VERSION     DAEPID010000062.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 22313)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 22313)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..22313
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.062"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            <1..369
                     /gene="tuf"
                     /locus_tag="KR257_002695"
     CDS             <1..369
                     /gene="tuf"
                     /locus_tag="KR257_002695"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009887863.1"
                     /note="EF-Tu; promotes GTP-dependent binding of
                     aminoacyl-tRNA to the A-site of ribosomes during protein
                     biosynthesis; when the tRNA anticodon matches the mRNA
                     codon, GTP hydrolysis results; the inactive EF-Tu-GDP
                     leaves the ribosome and release of GDP is promoted by
                     elongation factor Ts; many prokaryotes have two copies of
                     the gene encoding EF-Tu; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="elongation factor Tu"
                     /protein_id="HBH0031375.1"
                     /translation="DNIGALLRGVQRNEIERGQVLAKTGSVKAHTKFTAEVYVLKKEE
                     GGRHTPFFDGYRPQFYFRTTDVTGACKLPEGIEMVMPGDNVTMEVDLINSIVVEEGLR
                     FSIREGGRTVASGVVATIIE"
     gene            741..1052
                     /gene="rpsJ"
                     /locus_tag="KR257_002696"
     CDS             741..1052
                     /gene="rpsJ"
                     /locus_tag="KR257_002696"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860633.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S10"
                     /protein_id="HBH0031376.1"
                     /translation="MAKNEKIRIRLKSYDHKLLDFSAGKIVETAKKAGSQVSGPVPLP
                     TEKQVVTILRAVHKYKDSREQFEIRTHKRLIDIANPTPKTVDSLMRLDLPAGVDIEIK
                     L"
     gene            1144..1773
                     /gene="rplC"
                     /locus_tag="KR257_002697"
     CDS             1144..1773
                     /gene="rplC"
                     /locus_tag="KR257_002697"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421173.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L3"
                     /protein_id="HBH0031377.1"
                     /translation="MKGILGKKVGMTQIFTDKGVVIPVTAVEAGPMVVTQIKTVDKDG
                     YNAIQIGFEDAKEKALNKPKKGHLAAANVLKKHLKEFRVDSVEGYTVGQEIKADVFEA
                     GAKIDVTGISKGKGFQGPIKRHGQSRGPETHGSRYHRRPGSMGACSYPGRVFKNKKLA
                     GHMGSVKVTVQNLEVVKVDADKNLILVKGAIPGAKGSVVTIKEAIKVSK"
     gene            1803..2426
                     /gene="rplD"
                     /locus_tag="KR257_002698"
     CDS             1803..2426
                     /gene="rplD"
                     /locus_tag="KR257_002698"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001127258.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L4"
                     /protein_id="HBH0031378.1"
                     /translation="MPKLNVLNVSGQNVGEIELSDSIFGVEVNGHVLYEVVKNQLANK
                     RQGTQSAKTRAEVRGGGRKPWKQKGTGRARQGSTRSVQWVGGGVAFAPKPRSYKYTLP
                     KKVRRLAMKSALSSKVQNSEVIVLDALNMDAPKTKEFAQILNNINAAKKALVVIADKN
                     DNVIKSARNIEGVQTALVNTMNVYDILKYDSFIITTDAVKKVEEVYA"
     gene            2426..2716
                     /gene="rplW"
                     /locus_tag="KR257_002699"
     CDS             2426..2716
                     /gene="rplW"
                     /locus_tag="KR257_002699"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001205558.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L23"
                     /protein_id="HBH0031379.1"
                     /translation="MTNPHDVIIRPVVTEHSMAEMGEKKYTFVVAKDANKTEIKKAVE
                     KVFGVSVDKVNTLNYDGKVKRMGRTQGRTSSFKKAVVKLTADSKEIEFFQGM"
     gene            2746..3576
                     /gene="rplB"
                     /locus_tag="KR257_002700"
     CDS             2746..3576
                     /gene="rplB"
                     /locus_tag="KR257_002700"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421168.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L2"
                     /protein_id="HBH0031380.1"
                     /translation="MAIKKFRPTSPALRQMTVLVSDEITCNQPEKSLLVNLKKNAGRN
                     VHGRITVRHRGGGQKRKYRIIDFKRDKDGIPAKVATIEYDPNRTANIALLNYADGEKR
                     YILAPVGINVGDTILSGLGADIKPGNCLALKDMPVGTIIHNIELKPGKGAQLVRSAGV
                     SAQLMAKEGKNALLRLPSGEMRLVSINCKATIGQVGNIEHGNVVIGKAGRKRHMGIRP
                     TVRGSVMNPNDHPHGGGEGRSPIGRPSPVTPWGKPALGYKTRKKNKASNKLIVSRRTK
                     "
     gene            3611..3892
                     /gene="rpsS"
                     /locus_tag="KR257_002701"
     CDS             3611..3892
                     /gene="rpsS"
                     /locus_tag="KR257_002701"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003454422.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S19"
                     /protein_id="HBH0031381.1"
                     /translation="MSRSTKKGPFVHARLLKKIEAMNASGNKEVIKTWSRSSTVFPQM
                     VENTIAVHDGRKHVPVYITEDMVGHKLGEFVPTRTFKGHKDDEKSNKRK"
     gene            3924..4259
                     /gene="rplV"
                     /locus_tag="KR257_002702"
     CDS             3924..4259
                     /gene="rplV"
                     /locus_tag="KR257_002702"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018590372.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L22"
                     /protein_id="HBH0031382.1"
                     /translation="MEAKATAKYVRVSPRKAGQICDLVRGKNVDEALAILKFTPRGAA
                     SIIAKVVKSAKANAENNHEMDTEKLYIASIVANQGPTMKRFMPRAMGRATTIRKRTSH
                     IEVVVKEKK"
     gene            4282..5097
                     /gene="rpsC"
                     /locus_tag="KR257_002703"
     CDS             4282..5097
                     /gene="rpsC"
                     /locus_tag="KR257_002703"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421163.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S3"
                     /protein_id="HBH0031383.1"
                     /translation="MGQKVNPHGLRVGVIKDWDSRWFATDKKEFGNLLLEDHNIRKFL
                     KKRLYSAGVAKIEIERSANKIKMDLHVAKPGVVIGRAGAGIEALKAELEKMTKKTIIV
                     NIVEVRSTDKNAQLVAENIALAIERRVAFRRAMKQAIQRAMKSGAKGIKVSASGRLGG
                     AEMARTEGYSEGNVPLQTLRADIDYGFAEADTTYGKIGIKVWICNGEVLPTRDGVNPR
                     EESRKSDRRDNKRDNRRNDRRGNDRRGNDNRGNYRGQRPQGGSRPQRTENKGN"
     gene            5133..5564
                     /gene="rplP"
                     /locus_tag="KR257_002704"
     CDS             5133..5564
                     /gene="rplP"
                     /locus_tag="KR257_002704"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421160.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L16"
                     /protein_id="HBH0031384.1"
                     /translation="MLMPKRVKRRRVHRGSMAGQAHKGNKVTYGEFGLVALEASWITS
                     NQIEAARIAMTRYIKRGGKVWIKIFPHKPVTRKPAETRMGAGKGSPEYWVAVVKPGRV
                     MFELAGVSEDKAREAMRLAAHKLPIKCKFVKKEDLEVKGGE"
     gene            5566..5769
                     /gene="rpmC"
                     /locus_tag="KR257_002705"
     CDS             5566..5769
                     /gene="rpmC"
                     /locus_tag="KR257_002705"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005810148.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L29"
                     /protein_id="HBH0031385.1"
                     /translation="MKAKELRDLTSEELMNKLNDFKSELFSLRFQLATGQLENTARIK
                     FVKKDIAKVKTVLAERKLYETRA"
     gene            5793..6047
                     /gene="rpsQ"
                     /locus_tag="KR257_002706"
     CDS             5793..6047
                     /gene="rpsQ"
                     /locus_tag="KR257_002706"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018590376.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S17"
                     /protein_id="HBH0031386.1"
                     /translation="MERGRRKVRIGRVVSDKMDKTIVVAVEEFVRHPLYNKRVKRTKK
                     FKAHDEKNICNIGDRVKIMETRPLSKDKRFRLVEVVEKVK"
     gene            6073..6441
                     /gene="rplN"
                     /locus_tag="KR257_002707"
     CDS             6073..6441
                     /gene="rplN"
                     /locus_tag="KR257_002707"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007885948.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L14"
                     /protein_id="HBH0031387.1"
                     /translation="MIQQESRLRVADNSGAKELLCIRVLGGSKRRYGNIGDVIVATVK
                     SATPGGVVKKGKVVKAVIVRSKQGVRRNDGSYISFDENAAVIIKDDKTPVGTRIFGPV
                     ARELRDNEFMKIVSLAPEVL"
     gene            6465..6770
                     /gene="rplX"
                     /locus_tag="KR257_002708"
     CDS             6465..6770
                     /gene="rplX"
                     /locus_tag="KR257_002708"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003427723.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L24"
                     /protein_id="HBH0031388.1"
                     /translation="MRVKKGDTVVVIAGKDKGKKGSVLKVYPKTSKVLVEGVNVITKH
                     QKPSAMNQQGGIINKEAPIHISNVMPFDPETGKGVRVRYEVKDGNKVRVSAKSGKEL"
     gene            6800..7342
                     /gene="rplE"
                     /locus_tag="KR257_002709"
     CDS             6800..7342
                     /gene="rplE"
                     /locus_tag="KR257_002709"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018590379.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L5"
                     /protein_id="HBH0031389.1"
                     /translation="MASRLQEKYMKEVAPALMEKFGYKNVMEIPKLNKIVINMGIGDA
                     RENPKGLEKGVEELEMISGQKPVITKARKSVANFKLREGMPIGTKVTLRADKMFYFMD
                     KLVSVSLPRVRDFRGVNPNAFDGRGNYALGVKEQLIFPEIEYDKIDKVRGMDIIFVTT
                     AKTDEEARELLKLLGMPFSK"
     gene            7360..7545
                     /locus_tag="KR257_002710"
     CDS             7360..7545
                     /locus_tag="KR257_002710"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421149.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type Z 30S ribosomal protein S14"
                     /protein_id="HBH0031390.1"
                     /translation="MARKAMVVKQQRKQKYATREYTRCTICGRPHSVLKKFGICRICF
                     RELAYKGQIPGVRKASW"
     gene            7578..7976
                     /gene="rpsH"
                     /locus_tag="KR257_002711"
     CDS             7578..7976
                     /gene="rpsH"
                     /locus_tag="KR257_002711"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012158382.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S8"
                     /protein_id="HBH0031391.1"
                     /translation="MTMTDPIADMLTRIRNANVVKHETVDVPASNMKKELARILLEEG
                     FIRGYDVIEDGKQGIIRIQLKYGQEGERVITGLKKISKPGMRVYAANHEIPKVLNGLG
                     ISVISTSKGILTDKQARKENVGGEVICYVW"
     gene            8007..8549
                     /gene="rplF"
                     /locus_tag="KR257_002712"
     CDS             8007..8549
                     /gene="rplF"
                     /locus_tag="KR257_002712"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421144.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L6"
                     /protein_id="HBH0031392.1"
                     /translation="MSRIGVKPIIIPAGVEVTIAEGNLVTVKGPKGTLTKQLSAELNI
                     KKEENTIMVERPTDNKKHRSLHGLTRTLLDNMVVGVNTGFEKKLELKGVGYRAQKQGK
                     KLVMNLGFSHPVEMEDPEGITVEAPNQTELIVKGIDKQLVGNYAAKIRAWRKPEPYKG
                     KGIKYVDEVIRRKEGKTGKK"
     gene            8585..8953
                     /gene="rplR"
                     /locus_tag="KR257_002713"
     CDS             8585..8953
                     /gene="rplR"
                     /locus_tag="KR257_002713"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000628816.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L18"
                     /protein_id="HBH0031393.1"
                     /translation="MLKKADKNANRLQRHKRVRRKISGTSQRPRLCVFRSANNIYAQI
                     IDDTKRVTLVAASSLEAEVKSAVNHTGNKEAAKKVGELVAKKAVEKGITEVVFDRGGY
                     LYHGRIQELAEGAREAGLKF"
     gene            8974..9483
                     /gene="rpsE"
                     /locus_tag="KR257_002714"
     CDS             8974..9483
                     /gene="rpsE"
                     /locus_tag="KR257_002714"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011109776.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S5"
                     /protein_id="HBH0031394.1"
                     /translation="MLRRKPIDAGQLDLQEKVVEVRRVTKVVKGGRNFRFAALVVVGD
                     ENGHVGIGAGKAMEVPDAIKKAVEDAKKNLIVVPIVGTTIPHEVRGHFGAGNILIMPA
                     VEGTGVIAGGPARAVLELAGLKDVRAKSLGSNNPRNMVNATIEGLNSLKTVEDIAKLR
                     GKKVEELLG"
     gene            9498..9683
                     /gene="rpmD"
                     /locus_tag="KR257_002715"
     CDS             9498..9683
                     /gene="rpmD"
                     /locus_tag="KR257_002715"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421137.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L30"
                     /protein_id="HBH0031395.1"
                     /translation="MAKLQIKLVRSVIGTTPNQKKNVEALGLRKREQVVVKEDNAQTR
                     GMINKVSHLLEVTEIAE"
     gene            9716..10159
                     /gene="rplO"
                     /locus_tag="KR257_002716"
     CDS             9716..10159
                     /gene="rplO"
                     /locus_tag="KR257_002716"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000766080.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L15"
                     /protein_id="HBH0031396.1"
                     /translation="MKLHELKPAEGAVRAKRRLGRGTATGQGKTAGRGQKGQWSRSGG
                     GVRVGFEGGQMPLARRLPKRGFNNIFKKVYTEVNVEVLNRFENGTEITAELLKSTKTI
                     SKIGKDGIKILGEGNLEKALTVKAAKFTASAQEKIEKAGGKAELV"
     gene            10203..11471
                     /gene="secY"
                     /locus_tag="KR257_002717"
     CDS             10203..11471
                     /gene="secY"
                     /locus_tag="KR257_002717"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421133.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="preprotein translocase subunit SecY"
                     /protein_id="HBH0031397.1"
                     /translation="MLSKLKQAWKIKAVRKKVMYTLMMIVIFRIGTTIPVPGIDTSII
                     QKMVGGNSLLSLYNMFTGGAFSNFSLFALGISPYITASIIIQLLTVGFESLAELQKSG
                     EEGKKKINKYTKYTALALAVVQALGITLGIVRSALISNSVFFITTVVITLVSASMLVM
                     WIGDKITEKGIGNGSSVIIFAGIISRIPTDVIKISQQVKSGEVAPWVIVILAVVILLT
                     VTGVTFIQEATRKIPVQYAKRVVGRKMYGGQSSHIPMKVNQSGVMPIIFASSLLAFPQ
                     TIAMFMGPNAQAFVQKYLSMATEQGFWTYRSIEILLIIFFSYFYTTVSFNTEDISKNM
                     KNNGGFIPGIRPGEPTMDYLNRILTRLTLAGATFLAIIAMVPALTTHYMKVNMSLAGT
                     SLLIVVGVALELKRQLESNLVMRSYQGFLK"
     gene            11488..12138
                     /locus_tag="KR257_002718"
     CDS             11488..12138
                     /locus_tag="KR257_002718"
                     /EC_number="2.7.4.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009904768.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="adenylate kinase"
                     /protein_id="HBH0031398.1"
                     /translation="MRIILLGPPGAGKGTQAAGIVEKYNIPHISTGDIFRKNIKEGTE
                     LGKKAKEYMDQGLLVPDELTVGLVTDRISQEDCKNGFMLDGFPRNVAQGEHLDIFLKN
                     AGISLDKVVNIEVDKSILVSRAVGRRICKSCGATYHVEFNPPKVEGVCDVCQGELYQR
                     ADDNEETVSKRIQVYLDETKPLVDYYSKQGIIADIKGDQAIDKVFEDIVAALGSGK"
     gene            12139..12885
                     /gene="map"
                     /locus_tag="KR257_002719"
     CDS             12139..12885
                     /gene="map"
                     /locus_tag="KR257_002719"
                     /EC_number="3.4.11.18"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421130.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type I methionyl aminopeptidase"
                     /protein_id="HBH0031399.1"
                     /translation="MIILKSKKEIELLREAGKIVADTHEVLRKAISPGISTLELDKIA
                     EENIRKYNAEPSFKGYGGFPGSICASINREVVHGIPGETILQEGDIVSLDIGAYYKGY
                     HGDSAKTHGVGMISEEDRKLIEVTRESFYEGIKFAKLGYRLSDISHAVQTHVEKHGFS
                     VVRDLVGHGVGANLHEDPQVPNYGLPGKGPRLREGMVIAIEPMVNAGRYHVKTLSDGW
                     TTVTIDGKKSAHYEHTIAITEHEPLILTKL"
     gene            12907..13176
                     /locus_tag="KR257_002720"
     CDS             12907..13176
                     /locus_tag="KR257_002720"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892559.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="KOW domain-containing protein"
                     /protein_id="HBH0031400.1"
                     /translation="MLSDNLSIGQVVKVSLGRDKGNLFFVVKIINNEYVLIADGKKRK
                     LDKPKLKKVKHLKKYNFINDEVRKRVVSGQEITDSFLRAELTKLN"
     gene            13214..13432
                     /gene="infA"
                     /locus_tag="KR257_002721"
     CDS             13214..13432
                     /gene="infA"
                     /locus_tag="KR257_002721"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001029884.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="translation initiation factor IF-1"
                     /protein_id="HBH0031401.1"
                     /translation="MAKKDVIELEGTVSEALPNAMFKVKLENGHEILCHISGKLRMNF
                     IRILEGDKVNVELSPYDLTRGRITWRKK"
     gene            13468..13581
                     /gene="rpmJ"
                     /locus_tag="KR257_002722"
     CDS             13468..13581
                     /gene="rpmJ"
                     /locus_tag="KR257_002722"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003720928.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L36"
                     /protein_id="HBH0031402.1"
                     /translation="MKVRPSVKPICEKCKVIKRKGKVMVICENPKHKQKQG"
     gene            13734..14105
                     /gene="rpsM"
                     /locus_tag="KR257_002723"
     CDS             13734..14105
                     /gene="rpsM"
                     /locus_tag="KR257_002723"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005810116.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S13"
                     /protein_id="HBH0031403.1"
                     /translation="MARIAGVDLPREKRAEIGLTYIYGIGKATANEILAKAEINPDTR
                     IKDLSEDQVNELRKVIDDDFLVEGDLRREIALNIKRLRDIKCYRGIRHAKGLPLRGQR
                     TKTNARTRKGPRKTVSRKKKK"
     gene            14141..14539
                     /gene="rpsK"
                     /locus_tag="KR257_002724"
     CDS             14141..14539
                     /gene="rpsK"
                     /locus_tag="KR257_002724"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006440523.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S11"
                     /protein_id="HBH0031404.1"
                     /translation="MAKPKKKVTRIRRRERKNIERGHAHIQSTFNNTIITLTDVHGNA
                     ISWASSGQLGFKGSRKSTPFASQMAAETAAKAAMEHGLKSVEVFVKGPGSGREAAIRA
                     LQATGLEVTMIKDVTPIPHNGCRPPKRRRV"
     gene            14571..15194
                     /gene="rpsD"
                     /locus_tag="KR257_002725"
     CDS             14571..15194
                     /gene="rpsD"
                     /locus_tag="KR257_002725"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421121.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S4"
                     /protein_id="HBH0031405.1"
                     /translation="MARYTGASCRQCRREGMKLFLKGDRCYTDKCAIVKRNYAPGQHG
                     QGRKKVSNYGLQLREKQKVKRIYGVLETQFRNLYERAENMPGKAGENLLSLLERRLDN
                     VVYRMGLASSRKEARQLVTHGHFTLNGNKVDIPSLIVKVGDVIEVKEKSRSSAKFKNL
                     VEVNSRIAPKWLEANVEGMTAKVVGVPTREDIDLEIAEHLIIELYSK"
     gene            15272..16219
                     /locus_tag="KR257_002726"
     CDS             15272..16219
                     /locus_tag="KR257_002726"
                     /EC_number="2.7.7.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003427733.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA-directed RNA polymerase subunit alpha"
                     /protein_id="HBH0031406.1"
                     /translation="MIEIEKPKVDIVELSEDYRYGKFVIEPLERGYGITIGNALRRIL
                     LSSLPGVAVNAIKIDGVLHEFSTIPGVKEDVTEIILTLKELSATIDGEGSRTLKIEAQ
                     GPCSITGADIICPPDVEILSKDLAIATLDDNAKLNMEIFVDKGRGYVSAEENKTENVP
                     IGVLPVDSIYTPVEKVSYHVENTRVGQKTDYDKLVLEVWTNGSINPQEGISLAAKVLV
                     EHLNLFIDLTEHVSSVEIMVEKEEDQKEKVLEMTIEELDLSVRSYNCLKRAGINTVEE
                     LANKSEDDMMKVRNLGKKSLEEVIQKLEELGLGLKPSEE"
     gene            16240..16581
                     /gene="rplQ"
                     /locus_tag="KR257_002727"
     CDS             16240..16581
                     /gene="rplQ"
                     /locus_tag="KR257_002727"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003357477.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L17"
                     /protein_id="HBH0031407.1"
                     /translation="MAKYRKLGRETAHRNLMLRNLVTCLLRSGRIETTVTRAKETRRM
                     AEKMITLAKRGDLHARRQVLAYVMDETVVNNLFTDLAPKYAERNGGYTRIIKIGPRKG
                     DAAEMAFIELV"
     gene            16701..17534
                     /locus_tag="KR257_002728"
     CDS             16701..17534
                     /locus_tag="KR257_002728"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435660.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="energy-coupling factor transporter ATPase"
                     /protein_id="HBH0031408.1"
                     /translation="MDNIVKVNNISFEYITDEAKLKAIDNLSLDVKKGEFVAIIGHNG
                     SGKSTLSKNLNAILMPTEGNILIDDMDTKEEERLWDIRQTAGMVFQNPDNQIVATIVE
                     EDVAFGPENLGIEPKEIRRIVEESLKSVGMYDLRDRQPHLLSGGQKQRVAIAGIIAMR
                     PKCIIFDEATAMLDPSGRKEVMKTIKRLNKEENITVIHITHFMEEAVEADRVVVMEKG
                     KKILEGTPREVFSKIKMLKEIGLDVPCMTELSSLLIEEGINISSDILTVDEMVMELCQ
                     L"
     gene            17522..18388
                     /locus_tag="KR257_002729"
     CDS             17522..18388
                     /locus_tag="KR257_002729"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003427735.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="energy-coupling factor transporter ATPase"
                     /protein_id="HBH0031409.1"
                     /translation="MSIIVKNLTHIYNEGMPFASKALDDVSFEIKDRDFVGLIGHTGS
                     GKSTLIQHLNGLLKPSSGEIFINDFNITDKNLNLTEIRKRVGVVFQYPEYQLFEETID
                     KDIAFGPSNLGLEESEIHNRVKASMEAVGLDYEGFKDKSPFELSGGQKRRVAIAGVIA
                     MNPEVLILDEPTAGLDPGGRDEIFNLIKDLHEKKNMTIILSSHSMDDMAKLAKTLIVM
                     NHGSVEFMGTPREVFKSNASKLKDIGLDIPQVLELALKLREKGFDISEDILTLEEAKQ
                     EILKVVRGRGLC"
     gene            18382..19185
                     /locus_tag="KR257_002730"
     CDS             18382..19185
                     /locus_tag="KR257_002730"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860635.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="energy-coupling factor transporter transmembrane
                     protein EcfT"
                     /protein_id="HBH0031410.1"
                     /translation="MLKDITIGQYYPTSSAIHKLDPRIKLVATIVFMVSIFVVNKFWP
                     YIVVLLCLLAMIKLANIPVKYIVKGVKPLKWIILFTFLINIFFLPGDEIWSFGFLAIT
                     KQGLRQAIFMAIRLIFLVVGTSLLTLTTSPIELTDGIERLLNPFKKIGLPVHELAMMM
                     TIALRFIPTLLDETDKIMKAQMSRGADFESKNLINRAKNLVPLLVPLFVSAFRRADEL
                     AMAMEARCYRGGHNRTKMRESVISRRDYMACVFQVVYLGAIIATRFIAI"
     gene            19217..19948
                     /gene="truA"
                     /locus_tag="KR257_002731"
     CDS             19217..19948
                     /gene="truA"
                     /locus_tag="KR257_002731"
                     /EC_number="5.4.99.12"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003514691.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA pseudouridine(38-40) synthase TruA"
                     /protein_id="HBH0031411.1"
                     /translation="MRNIKIKIQYNGKNYCGWQKQPDSLGIQGTIERAIYDITKEETS
                     LIGSGRTDSGVHAIGQIANFKINSGISIESIPMALNAKLPKDISVIEACEVNDDFHSR
                     YSAKGKTYKYLVYNSKFRNPILSEISYQVKYELDFDKMCSEAKSLLGTHDFKGFMSSG
                     SSVKDTVRTIYDIDISKKDDLITFEISGNGFLYNMVRIIVGTLVDMGRGRINEPFLDI
                     IQSKTRSRCGHTAPAQGLFLKKVHY"
     gene            20068..20499
                     /gene="rplM"
                     /locus_tag="KR257_002732"
     CDS             20068..20499
                     /gene="rplM"
                     /locus_tag="KR257_002732"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435651.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L13"
                     /protein_id="HBH0031412.1"
                     /translation="MKSYIAKPADVQRKWYLVDAEGKTLGRLATEIATVLRGKHKPTF
                     TPHVDGGDFVVVVNAEKIVLSGKKLDQKYYRYHTGYVGGLKEISYRDMMDKKPEEVIS
                     HAVSGMLPKNKLRSRMMTRLRVFAGAEHTHAAQNPEVLNFK"
     gene            20528..20920
                     /gene="rpsI"
                     /locus_tag="KR257_002733"
     CDS             20528..20920
                     /gene="rpsI"
                     /locus_tag="KR257_002733"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003515879.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S9"
                     /protein_id="HBH0031413.1"
                     /translation="MANVQYYGTGRRKSSVARVRLVAGEGNILVNGRALENYFNYETL
                     IRDVKQPLVLTGNENKYDVIVKVEGGGFTGQAGAIRHGISRALLKADLDLRPALKKEG
                     FLTRDARMKERKKYGLKAARRAPQFSKR"
     gene            21379..22131
                     /gene="cwlD"
                     /locus_tag="KR257_002734"
     CDS             21379..22131
                     /gene="cwlD"
                     /locus_tag="KR257_002734"
                     /EC_number="3.5.1.28"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435644.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="N-acetylmuramoyl-L-alanine amidase CwlD"
                     /protein_id="HBH0031414.1"
                     /translation="MEYYSVFISIHIQGDVVRKYIKHIIFSFAMICLVVVSIFEIKNI
                     SEDVIKYMPVTNKTIILDAGHGGIDPGALNKDKSTSEKDINLAITLKLRELIESSGGL
                     VILTREDDSSLYKEENNKTTRQKYNENLKNRKEIISNSNANMFVSIHLNAFEQSKYYG
                     AQTFYPKDKQDSKELSKCIQEELKRVVDKTNNREVKPRDDIYLLKENNIPSVLIECGF
                     LSNEKECKLLTDETYQEKIAWAIYIGIQKYLS"
BASE COUNT         8969 a         2609 c         4585 g         6150 t
ORIGIN      
        1 gataatatag gagcattatt aagaggagta caaagaaacg agatagaaag aggacaagta
       61 ctagcaaaga ctggatcagt aaaggcacac acaaagttta cagcagaagt atatgtactt
      121 aaaaaagaag aaggtggaag acatacacca ttctttgatg gatatagacc acaattctat
      181 ttcagaacaa cagacgtaac aggagcttgt aagttaccag aaggaataga gatggtaatg
      241 cctggagata acgtaacaat ggaagtagac ttaataaact caatagttgt agaagaggga
      301 ttaagattct caataagaga aggtggaaga acagtagctt caggagttgt tgctacaata
      361 atagagtaat cctttactaa actaatggat ttaatataaa aaaagagggg ggtaactcct
      421 ctcttttttg ttttttgttg acaagtagcg ctaaagcata tatactaaac tagtgccttg
      481 agacagatta acaatcaagt ttaaggttat gatgttgtaa tagaaaataa aattgaaaaa
      541 aacagaaaaa aaacttgaaa aaatgtaaca gatgatataa aatataatag tgtgcttgag
      601 agattaagaa aataataatt aaatcctagt gaaatacgaa ctgatatcga tttaaaagtt
      661 acaacacacc cggagcagtg tatcggtatt ggttgtacgc aacttgaaaa ttaaacacgt
      721 gataaaggag ggaaaacaaa atggctaaga atgaaaaaat aagaataaga ttaaaatcat
      781 atgatcacaa attattagat ttttcagcag gtaaaatagt tgaaactgct aaaaaggctg
      841 gatcacaagt ttcaggacct gtgcctctac caacagaaaa acaagttgta actatattaa
      901 gagctgtaca taagtacaaa gactctagag aacaatttga aataagaact cataaaagac
      961 taatcgacat agctaatcca acacctaaga cagttgactc attaatgaga ttagacttac
     1021 cagcaggtgt agatatagaa ataaaattat aagaacccct aagatattat cctatagatg
     1081 attatcttag aatgattact ctaaaagatg taatccgctg taagaattat aggaggtgct
     1141 aatatgaaag gaatattagg caaaaaagtt ggtatgactc aaatattcac tgataaaggt
     1201 gtagttatac ctgtaacagc tgttgaagca gggcctatgg tcgttactca aataaaaaca
     1261 gttgataaag atggatacaa tgctatacaa ataggttttg aagatgctaa agaaaaagct
     1321 ttaaacaaac ctaaaaaagg acatttagct gctgctaatg ttttaaagaa acatttaaaa
     1381 gaatttagag tagattctgt agaaggatac acagtaggac aagaaataaa agctgatgta
     1441 tttgaagcag gtgcaaaaat agatgttact ggaataagta aaggtaaggg attccaaggt
     1501 ccaataaaaa gacatggaca aagtagaggt cctgaaactc acggttctag ataccacaga
     1561 agaccaggtt caatgggagc ttgttcttac ccaggtagag tatttaaaaa caaaaaatta
     1621 gctggacata tgggaagcgt aaaggtaaca gttcaaaact tagaggttgt taaagtagat
     1681 gctgacaaga accttatatt agttaaagga gctataccag gagctaaagg ttcagtagta
     1741 actataaaag aagctataaa ggtttctaaa taatgactaa cctagagaaa ggaggaataa
     1801 caatgccaaa attaaatgta ctaaatgtta gtggacaaaa cgttggagaa atagaattat
     1861 cagattctat atttggcgta gaagttaatg gacatgtttt atacgaagtt gtaaaaaatc
     1921 aattagcaaa taagagacaa ggaactcaat ctgctaaaac tagagcagaa gttagaggtg
     1981 gcggaagaaa accttggaaa caaaaaggaa caggtagagc aagacaaggt tctacaagat
     2041 ctgtacaatg ggtaggtgga ggagttgctt ttgcacctaa accaagaagc tacaaatata
     2101 cattacctaa gaaggtaaga agattagcta tgaagagtgc tttatcttca aaagttcaaa
     2161 atagtgaagt tatagtatta gatgcattaa acatggatgc tcctaagact aaagaatttg
     2221 ctcaaatatt aaacaatata aatgctgcta aaaaagcttt agtagttata gctgacaaaa
     2281 acgataacgt aataaaatca gctagaaata tagaaggtgt tcaaactgca ttagttaata
     2341 ctatgaatgt atatgatata ttaaaatacg attcatttat aataactaca gatgctgtta
     2401 aaaaagtgga ggaggtgtac gcataatgac taatccacat gatgtaataa taagaccagt
     2461 tgtaactgag cacagtatgg ctgaaatggg tgaaaaaaaa tacacttttg ttgtggctaa
     2521 agatgcgaac aaaactgaaa taaaaaaagc agtagaaaaa gtattcggag ttagtgttga
     2581 taaagtaaat actttaaact acgatggaaa agttaaaaga atgggtagaa ctcaaggaag
     2641 aacatcaagc tttaagaaag cagtagttaa attaactgct gatagtaaag aaatagaatt
     2701 cttccaagga atgtagtatt ataacaaacg aaggagggaa aacagatggc tataaaaaag
     2761 tttagaccaa cttctcctgc cttaagacaa atgacagttt tagtttctga tgaaataaca
     2821 tgtaatcaac cagaaaaatc tcttttagtt aacttaaaga aaaatgctgg tagaaacgta
     2881 catggtagaa taactgttcg tcatagaggt ggaggacaaa aaagaaaata tagaataata
     2941 gattttaaaa gagataaaga tggtatacct gctaaggttg ctactataga atatgatcca
     3001 aacagaactg caaatatcgc attattaaac tatgctgatg gagaaaaaag atatatatta
     3061 gctccagttg gaattaatgt tggagatact atattatcag gattaggtgc tgatataaaa
     3121 ccaggaaact gtttagcatt aaaagatatg ccagttggta ctatcattca taatatagaa
     3181 ttaaagccag gaaaaggagc tcaattagtt agatctgctg gagtttctgc acaattaatg
     3241 gctaaagaag gaaaaaatgc tttattaaga ttaccatcag gtgagatgag attagtaagc
     3301 ataaactgta aagctactat aggtcaagtt ggaaatatag agcatggtaa cgtagttatc
     3361 ggtaaagcag gtagaaaaag acatatggga ataagaccta ctgtaagagg ttctgtaatg
     3421 aaccctaatg accatccaca cggtggaggg gaaggtagat ctccaatagg tagaccatct
     3481 cctgttactc catggggtaa accagctctt ggatacaaaa ctagaaagaa aaataaagct
     3541 tcaaataaac taatagtatc aagaagaact aagtagtaaa tttatttttg ctcggaaagg
     3601 aggaatataa atgtcaagat caactaaaaa agggcctttt gtccatgcaa gacttttaaa
     3661 gaagatagaa gctatgaatg ctagtggaaa taaagaagtt ataaaaactt ggtcaagatc
     3721 ttcaactgta tttccacaaa tggtagaaaa cactatagct gttcatgatg gaagaaaaca
     3781 tgttccagta tatataacag aagatatggt tggacataaa ttaggtgagt tcgttcctac
     3841 tagaactttc aaaggacata aggatgacga aaaatctaat aagagaaaat aattaaatta
     3901 tgactaagaa aggaggaata acaatggaag caaaagctac tgctaaatac gtacgtgtat
     3961 caccaagaaa agcaggccaa atatgtgacc ttgttagagg aaagaatgtt gatgaagcat
     4021 tagcaatatt aaagtttact ccaagaggag cagcttcaat aatagctaag gttgtaaaat
     4081 cagctaaagc taacgcagaa aacaatcacg aaatggatac tgaaaaatta tatatagcat
     4141 caatagttgc taatcaagga ccaacaatga agagattcat gcctagagct atgggtcgtg
     4201 caactacaat aagaaaaaga acttctcata tagaggttgt tgttaaagaa aaaaaataat
     4261 taatagatag gagggaaagt aatgggtcaa aaggttaatc cacacggctt aagggtcggt
     4321 gttataaaag attgggactc aagatggttc gctactgata aaaaagagtt cggaaactta
     4381 ttattagaag accataatat acgtaaattc ttaaagaaaa gattatactc agctggagtt
     4441 gctaagatag aaatagaaag atcagctaac aaaataaaaa tggacttaca cgttgctaag
     4501 cctggtgtag ttataggaag agctggtgca ggaatcgaag cattaaaagc tgaattagaa
     4561 aaaatgacaa agaaaactat aatagttaat atagtagaag taagaagtac agataaaaat
     4621 gctcaattag tagctgaaaa tatagcttta gctatagaga gaagggttgc tttcagaaga
     4681 gcaatgaaac aagctataca aagagcaatg aaatctggtg ctaaagggat aaaagtttct
     4741 gcttcaggaa gattaggtgg agctgaaatg gctagaactg aaggttatag tgaaggaaat
     4801 gtgccactac aaactttaag agcagatata gattatggtt tcgctgaagc tgatacaact
     4861 tatggaaaaa tcggtataaa agtttggata tgtaatggtg aagttttacc aactagagac
     4921 ggtgtaaatc caagagaaga aagcagaaag agcgatagaa gagacaacaa gagagataat
     4981 agaagaaacg atagaagagg aaatgacaga agaggaaatg ataacagagg aaactacaga
     5041 ggacaaagac ctcaaggtgg atcaagacct caaagaactg aaaacaaagg aaattaataa
     5101 tagttaggtt caaggaagga ggaaaaatac tcatgttaat gccaaaaaga gtaaagcgtc
     5161 gtagagttca tagaggaagc atggctgggc aagctcataa gggtaataaa gttacttatg
     5221 gtgagtttgg attagtagca ttagaagctt cttggataac ttctaatcaa atagaagctg
     5281 ccagaatcgc gatgactaga tatataaaaa gagggggaaa ggtttggata aaaatattcc
     5341 ctcataaacc agtaacaaga aaaccagcag agactcgtat gggtgcaggg aaaggttctc
     5401 cagaatattg ggtagctgta gttaagccag gaagagttat gtttgaatta gcaggtgttt
     5461 ctgaagataa agcaagagaa gctatgagac ttgctgcaca taaattacca atcaaatgta
     5521 aatttgttaa aaaagaagat ttagaagtaa agggtggtga ataggatgaa agctaaagaa
     5581 ttaagagatt taacaagcga agagctaatg aacaaattaa acgacttcaa aagtgaatta
     5641 tttagcttaa gattccaatt agctactggt caattagaaa atacagctag aataaagttt
     5701 gttaagaagg atatagcaaa agttaaaact gttcttgctg aaagaaagtt atacgaaact
     5761 agagcttaat ttggaaagga ggctttttaa acatggaaag aggaagaaga aaagttagaa
     5821 taggccgtgt tgttagtgat aagatggata aaacaatagt agtagctgtt gaagaattcg
     5881 tacgtcatcc actatataat aaacgtgtta agagaactaa gaaattcaag gctcatgatg
     5941 aaaagaatat atgtaacatc ggagatagag ttaaaataat ggaaactaga ccattatcta
     6001 aagataagag attcagacta gttgaagttg ttgagaaagt taagtagttt ttgaagaagg
     6061 agggattacg atatgataca acaagaatca cgtctaagag ttgctgataa ctcaggagct
     6121 aaagaacttt tatgtatacg tgttctaggc ggaagtaaaa gaagatatgg taacataggc
     6181 gacgttatag ttgctactgt taaaagtgca acacctggtg gagttgtaaa aaaaggtaag
     6241 gttgttaaag ctgttatagt aagaagcaaa caaggcgtaa gacgtaatga cggaagctat
     6301 atatcttttg atgaaaatgc tgctgttata ataaaggacg ataaaactcc agtaggaact
     6361 cgtatattcg ggcctgttgc tagagagtta agagacaatg aattcatgaa aatagtttct
     6421 cttgctccag aagtactata attaaggagg tgcaatagga catgatgcgt gttaaaaaag
     6481 gtgacactgt tgtagttata gcaggtaaag ataaaggtaa aaaaggttca gttttaaagg
     6541 tatatcctaa aactagcaaa gtgttagttg aaggtgtaaa tgtaataact aaacatcaaa
     6601 aaccaagtgc tatgaaccaa caaggtggaa taataaataa agaagcccca atacacatat
     6661 ctaatgtaat gccatttgat cctgaaacag gaaaaggcgt tagagtaaga tatgaagtaa
     6721 aagatgggaa caaagtaaga gtatcagcaa agagcggaaa agaattataa taaatattgc
     6781 ttgaaaggag ggaccttaaa tggcttctag attacaagaa aaatacatga aagaagttgc
     6841 tcctgcttta atggagaaat ttggatacaa aaacgtaatg gagataccta agttaaataa
     6901 aatagttatt aacatgggta taggtgacgc tagagaaaat ccaaaaggat tagaaaaagg
     6961 cgttgaagaa ttagaaatga tatcaggaca aaagcctgtt ataactaaag ctagaaaatc
     7021 tgttgctaac ttcaaattaa gagaaggaat gccaatagga acaaaagtta cattaagagc
     7081 tgacaaaatg ttctacttca tggacaaatt agtttcagtt tctttaccaa gagttagaga
     7141 ctttagagga gttaacccta atgcttttga tggtagagga aattatgctt taggagttaa
     7201 agaacaatta atattccctg aaatagaata tgataaaata gataaagtaa gaggaatgga
     7261 tataatattt gttactacag caaaaactga cgaagaagct cgtgaattat taaaattatt
     7321 aggaatgcca ttttctaagt aagcaaagga gggattcccg tggctagaaa agcgatggtt
     7381 gttaagcaac aaagaaagca aaagtacgct actagagaat acactagatg tactatatgc
     7441 ggaagaccgc attcagtttt gaaaaaattt ggtatatgcc gtatatgctt tagagaatta
     7501 gcttataaag gtcaaatacc tggtgttaga aaagcaagct ggtagaagct tgattagaat
     7561 ggaaggaggg caacaaaatg acaatgacag atccaattgc agatatgctt actcgtataa
     7621 gaaatgctaa tgttgttaag catgaaactg tagatgttcc agcttctaat atgaagaaag
     7681 aattagctag aatcttatta gaagaaggtt tcataagagg ttatgatgtt atagaagatg
     7741 gaaaacaagg tatcataaga atacaattaa agtacggaca agaaggcgaa agagttataa
     7801 caggtcttaa gaaaatatct aagcctggaa tgagagttta cgctgctaac catgagatac
     7861 caaaagtatt aaacggatta ggaatatcag ttatatctac ttcaaaagga atattaactg
     7921 acaagcaagc tagaaaagaa aatgttggtg gagaagtaat ctgctacgtt tggtaattaa
     7981 tatgaacaat gtaaggaggt gcgaccatgt caagaatagg tgttaagcca ataataatac
     8041 cagcaggtgt tgaagttact atagctgaag gaaatttagt tacagtaaaa ggtccaaaag
     8101 gaactttaac taaacaatta agtgctgagt taaacataaa aaaagaagaa aatacaataa
     8161 tggttgaaag accaactgat aataaaaaac atagatcttt acacggacta actagaactt
     8221 tattagataa tatggttgta ggtgtaaata ctggtttcga aaagaaatta gaattaaaag
     8281 gtgttggata tagagctcaa aaacaaggaa agaaattagt tatgaactta ggtttctctc
     8341 atccagttga gatggaagat ccagaaggaa taactgttga agctccaaac caaacagagt
     8401 taatagtaaa aggtatagac aagcaattag tagggaatta tgctgctaag ataagagctt
     8461 ggagaaagcc agagccatac aaaggtaaag gtataaaata cgttgatgaa gtaatcagac
     8521 gtaaagaagg aaaaactggt aaaaaataat accaaaactt aaacgctaga aaggagtgag
     8581 ctaggtgtta aaaaaggctg ataaaaatgc taatagactt caaagacata agagagttcg
     8641 tagaaaaata agcggtactt ctcaaagacc aagattatgt gtatttagaa gtgctaacaa
     8701 tatatatgct caaataatag atgacacaaa aagagtaact ctagttgctg catcttcttt
     8761 agaagcagaa gttaagagtg ctgtcaatca tacaggaaac aaggaagcag ctaagaaagt
     8821 tggagaatta gttgctaaaa aagctgttga aaaaggaatc actgaagttg tatttgacag
     8881 aggtggatac ttatatcatg gaagaattca agaattagct gaaggtgcta gagaagctgg
     8941 tcttaagttc taatacgaag gagggaaaaa tacatgctac gtcgtaagcc gatagatgca
     9001 ggacaacttg acttacaaga aaaagttgtt gaagtaagac gtgttactaa ggttgtaaaa
     9061 ggtggtagaa atttcagatt tgcagcatta gtagttgttg gagatgaaaa cggacacgtt
     9121 ggtataggtg ctgggaaagc aatggaagta ccagacgcta taaaaaaagc agttgaagat
     9181 gctaagaaaa atctaatagt agtgccaata gttgggacta caattcctca cgaagtacgc
     9241 ggacactttg gtgctggaaa tatattaata atgcctgctg tagaaggtac aggagtaata
     9301 gctgggggac ctgctagagc cgtacttgag ctagctggac taaaagacgt tagagctaaa
     9361 tctttagggt ctaacaatcc aagaaatatg gtaaatgcta caatagaagg acttaattct
     9421 ctaaaaacag ttgaagatat agctaaactt agaggtaaaa aagttgaaga acttctaggg
     9481 taaggaggta gtgtaaaatg gctaaattac aaataaagtt agttagaagt gttataggaa
     9541 ctactcctaa ccaaaaaaag aatgttgaag cgttaggatt aagaaaaaga gaacaagttg
     9601 ttgtaaaaga agacaatgct caaacaagag gtatgataaa taaagtaagt cacttattag
     9661 aagtaactga aatagctgaa taatttttat aaagtagtgc aaggaggtgc aatccatgaa
     9721 gttacatgag ttaaaacctg ctgaaggtgc agtaagagct aagagaagat taggtagagg
     9781 tactgcaact ggacaaggta aaactgcagg acgtggacaa aaaggtcaat ggtctcgttc
     9841 tggtggtgga gtaagagtag gatttgaagg tggacaaatg ccactagcta gaagacttcc
     9901 taagagaggt ttcaataaca tatttaagaa agtttacaca gaagttaatg ttgaagtttt
     9961 aaacagattt gaaaatggaa cagaaataac tgcagaatta ttaaaatcta ctaaaactat
    10021 aagcaaaata ggtaaagacg gaattaaaat cttaggtgaa ggtaatttag agaaagcttt
    10081 aactgttaaa gctgctaaat ttacagcttc agctcaagaa aaaatagaaa aagctggtgg
    10141 aaaagcagag ttagtataat aacctgctaa tctcctagcc agtacaggcg gggtgaatta
    10201 gcgtgctgtc aaaattaaaa caagcttgga agattaaagc agtaagaaaa aaagtaatgt
    10261 atacacttat gatgatcgtg atattcagaa taggtactac tataccagtt ccaggcatag
    10321 acactagtat tatacaaaag atggtaggcg gcaatagtct actttctctg tataatatgt
    10381 ttactggtgg agcatttagt aacttttcac tatttgcttt aggtataagt ccatatatca
    10441 ctgcatcaat cataatacaa cttctaacag taggttttga aagtttagca gaacttcaaa
    10501 aatctggtga agaaggaaag aaaaaaatca ataagtacac taaatataca gcactagctc
    10561 tagcagttgt acaagctttg ggaattacat taggaattgt aagaagtgct ttaatatcaa
    10621 atagtgtgtt ttttatcaca actgttgtaa taacattagt ttcagcaagt atgttagtaa
    10681 tgtggattgg ggacaaaatt actgaaaaag gaatcggtaa tggtagttca gtaataatat
    10741 ttgcaggtat aatatcaaga atacctacag atgttattaa aatatcgcaa caagttaaat
    10801 ctggcgaagt tgcaccttgg gttatagtga ttctagctgt agttatatta cttacagtaa
    10861 caggagttac atttatacaa gaagcaacta gaaagatacc tgtacaatat gctaaaagag
    10921 ttgttggaag aaaaatgtat ggaggacaaa gttctcatat accaatgaaa gttaaccagt
    10981 caggagttat gcctataatt tttgctagtt cacttttagc tttccctcaa acaatagcta
    11041 tgtttatggg tccaaatgct caggcttttg ttcaaaaata cttaagtatg gcaacagaac
    11101 aaggattttg gacatataga tcaattgaga ttctacttat aattttcttc tcatattttt
    11161 atacaactgt atcatttaat acagaagaca tatctaaaaa tatgaaaaat aatggtggat
    11221 ttataccagg tataagacca ggtgagccta ctatggatta tttaaataga attttaacta
    11281 gattaacttt agctggagct actttcttag caataattgc tatggtgcca gctcttacaa
    11341 cacattatat gaaagtaaat atgagtctag ctgggacttc attgctaatc gttgttggag
    11401 ttgctttgga gcttaagaga cagttagagt caaacttagt tatgagaagc tatcaaggtt
    11461 tcttaaaata aaatggagat ggataatatg agaataatat tacttggacc tccaggtgct
    11521 ggtaaaggta ctcaggcggc aggaatagta gaaaaataca atatacctca tatatcaaca
    11581 ggagatatat tcagaaagaa tataaaagag ggaacagaac ttggaaaaaa agctaaagaa
    11641 tacatggacc aaggtttatt agtaccagat gagttaactg taggtttagt tactgataga
    11701 atatctcaag aagattgtaa aaatggattt atgttagatg gatttccaag aaatgtagca
    11761 caaggagaac atttagatat cttcttaaaa aatgctggta tatcactaga taaagttgtc
    11821 aatattgaag ttgataagag tatattagtg tctagagcag ttggtagaag aatatgtaag
    11881 tcttgtggag ctacttacca tgttgagttt aatcctccta aagtagaagg tgtatgtgat
    11941 gtatgccaag gagaattata tcaaagagct gatgataatg aagaaactgt atctaagaga
    12001 atacaagttt atctagatga aactaagcct ttagtagatt attatagcaa acaaggtata
    12061 atagcagata taaaaggtga tcaagcaata gataaagtat ttgaagatat tgtcgcagcc
    12121 ttaggaagtg gaaaataaat gattatcttg aaatcaaaaa aagaaataga acttttaaga
    12181 gaagcaggta aaatagttgc tgacactcat gaagttttaa gaaaagctat ttctccggga
    12241 atatctactt tagaattaga taaaatagct gaagagaata taagaaaata caatgcagaa
    12301 ccttctttta aaggatatgg aggttttcca ggaagtatat gtgcttctat caatagagag
    12361 gtagtacatg gtattccagg agaaactata ttacaagaag gtgacattgt aagtttggat
    12421 ataggagcct attataaagg atatcatggt gattctgcga aaactcacgg agtaggcatg
    12481 atatctgaag aagataggaa attgatagaa gtaactagag aaagcttcta tgaaggaata
    12541 aaatttgcta aattaggata tagactttca gatatctcac acgcagtaca aacacacgtt
    12601 gagaaacatg gtttctcggt agttagagat ttagtgggtc atggagttgg agcaaatctt
    12661 catgaagacc cacaagtacc taattatgga ctcccaggaa aaggaccaag acttagagaa
    12721 ggaatggtta ttgctataga gccaatggtt aatgcaggtc gttatcatgt aaagactcta
    12781 tcagatgggt ggacgactgt tacaatagat ggaaaaaaat cagctcatta tgagcatacg
    12841 atagcaatta ctgaacatga acctttgata ttgacaaagt tgtaatttaa aaagtaggtg
    12901 aaaaaagtgc tatcagataa tttaagtata ggtcaagttg ttaaagtttc attaggacga
    12961 gataaaggaa atttattctt tgtagtcaaa ataattaata atgaatatgt attaatagct
    13021 gatggaaaaa agagaaaact tgacaaacct aagttaaaga aagtgaagca cttaaaaaaa
    13081 tataatttta ttaatgatga agttagaaaa agagtagtat ctggacaaga gattacagat
    13141 tcttttttaa gagctgaact tactaagtta aattagataa tttaacttat tgaaatggag
    13201 ggctggttag ttaatggcca aaaaagatgt tatagaatta gaaggtacag tttcagaagc
    13261 tttacctaat gctatgttca aagttaaact agaaaatgga catgagatat tatgccacat
    13321 ttctggaaag ctaagaatga acttcataag aattcttgaa ggtgacaagg tgaatgttga
    13381 actttctcca tatgacctta caagaggaag aattacttgg cgtaagaagt agactatatt
    13441 aatatttagt ctaaggaggg attaataatg aaggttagac catcagtaaa accaatatgt
    13501 gaaaaatgta aagtaataaa aagaaaagga aaagtaatgg ttatctgtga aaatccaaag
    13561 cataagcaaa agcaaggata agaaattatt actagcattt tgttaaattt tatagtataa
    13621 tactatattg tgatgttaac aaaagaacgt taaaatcgtt gaacaatctg gcgtaggatt
    13681 ggcatatgat gtgaagtttt aaacactaaa aactatgtgt aggaggtgcg atcatggcaa
    13741 gaatagctgg ggtagattta cctagagaaa aaagagcgga gataggctta acttatatat
    13801 atggtatagg taaagcaact gctaacgaaa tattagctaa ggctgagata aatccagata
    13861 ctagaataaa agatttatca gaagatcaag ttaatgagtt aagaaaagtt atagatgacg
    13921 atttcttagt tgaaggtgac ttaagaagag aaattgcttt aaacataaag agattaagag
    13981 atataaaatg ttatagagga ataagacacg ctaaaggtct tccattaaga ggacaaagaa
    14041 ctaagactaa tgctagaact agaaaaggtc ctagaaaaac agtatctcgt aaaaagaaaa
    14101 aataaataaa taataactag atgaaggagg gaaaaggaaa atggctaaac caaaaaagaa
    14161 agttacacgt attagaagaa gagaacgtaa aaatatagaa cgtggtcatg ctcatataca
    14221 atcaactttc aataatacaa taataacttt aactgacgtt cacggaaatg ctatatcttg
    14281 ggcaagttct ggacaattag gattcaaagg atcaagaaaa tcaactccat ttgcatctca
    14341 aatggctgct gaaacagctg caaaagctgc gatggaacac ggactaaaaa gtgttgaggt
    14401 attcgtaaag gggccaggtt caggaagaga agctgcaata agagctttac aagcaactgg
    14461 actagaagta actatgataa aagacgttac tccaatccca cataacggat gcagaccacc
    14521 aaagagaaga agagtgtaat taataagagt acaataggag gtgtagataa atggcaagat
    14581 atacaggtgc atcatgtaga caatgccgta gagagggaat gaaattattc cttaaaggtg
    14641 atagatgtta tacagacaaa tgtgctatag taaaaagaaa ctatgctcca ggtcaacatg
    14701 gccaaggaag aaagaaagtt tctaactatg gattacaatt aagagaaaaa caaaaagtta
    14761 aaagaatata tggagtttta gagactcaat ttagaaattt atatgaacgt gctgaaaata
    14821 tgcctggtaa agcaggtgag aacttattaa gtttattaga gagaagatta gataatgtag
    14881 tttacagaat gggactagca tcttctagaa aagaagctag acaattagtg actcatggtc
    14941 atttcacttt aaatggaaat aaagtagaca taccttcatt aatagttaag gttggagatg
    15001 ttatagaagt taaagagaaa tcaagatctt ctgcaaaatt caaaaattta gtagaagtta
    15061 actcaagaat agctcctaag tggttagaag ctaatgtaga aggaatgaca gcaaaagtag
    15121 ttggtgttcc aacaagagaa gatatagatc ttgagatagc agagcactta atcatagaac
    15181 tttactctaa ataataagca cacttttaaa aattatttta aaattttgtt taccctcagt
    15241 ggattactga attttaagga gggttttgtc catgatagaa atagaaaagc caaaagtaga
    15301 tatagttgag cttagcgaag actatagata tggtaagttt gttatagagc ctctagaaag
    15361 aggatatgga ataactatag gtaacgcatt aagaagaata ttattatcat cattaccagg
    15421 tgtagcagtg aatgctataa aaatagatgg agttcttcat gaattttcaa caatacctgg
    15481 tgttaaagaa gatgttactg agataatatt aactttaaaa gagctttcag caactataga
    15541 tggtgaagga agtagaacac ttaaaataga agctcaagga ccatgctcta tcacaggtgc
    15601 agatataatc tgtcctccag atgttgaaat attaagtaaa gatttagcaa tagctacatt
    15661 agatgataat gctaaactta atatggagat atttgtagat aaaggtagag gttatgtttc
    15721 tgctgaagaa aataaaacag agaatgttcc aataggtgtt ttacctgtgg attcaatata
    15781 tactcctgtt gagaaggtta gttatcatgt ggaaaacaca agagttggtc aaaaaacaga
    15841 ttatgataaa ttagtattag aagtttggac taatggtagt ataaatcctc aagagggaat
    15901 atcattagct gcaaaggtat tagttgagca tttaaactta tttatagact taactgaaca
    15961 tgtaagtagt gttgaaatca tggtagaaaa agaagaagat caaaaagaaa aagttcttga
    16021 aatgactata gaagaattag atttatcagt tagatcatat aactgtttaa agagagcggg
    16081 aattaataca gttgaagaat tagctaataa atctgaggat gatatgatga aggttagaaa
    16141 cctaggtaag aagtcattag aagaggtaat acaaaaacta gaagaacttg gattgggatt
    16201 aaaaccaagt gaagaatagc gagcaaagga gggataagaa tggctaagta ccgtaaatta
    16261 ggacgtgaaa cagctcacag aaaccttatg ttaagaaact tagtaacttg cttactaaga
    16321 agtggaagaa tagaaactac agtgactaga gcgaaagaaa ctcgtagaat ggctgaaaag
    16381 atgataactc ttgctaagag aggagatctt catgctagaa gacaagtttt agcttatgtt
    16441 atggatgaaa cagtagttaa taacttattc acagatttag ctccaaaata tgctgagaga
    16501 aatggtggat acactagaat aataaaaata gggccaagaa aaggcgatgc tgctgaaatg
    16561 gcttttatag aattagtata gtaaggaaag gattaggctt gatggcttaa tctttttttt
    16621 atttttttga ctaaggtatg atataataat gtgtaaaatg atttttataa gttattgctt
    16681 actaaaagga gtatgagtta atggataata tagtaaaggt aaataatatt tcgtttgagt
    16741 atattacaga tgaagcaaaa cttaaagcaa tagataattt aagcctagat gttaaaaaag
    16801 gagaatttgt tgcgataata ggacataatg gttctggtaa gtctacttta tctaaaaact
    16861 taaatgctat tcttatgcct actgaaggaa atattcttat tgatgatatg gatactaaag
    16921 aagaagaaag attatgggat ataagacaaa ctgcaggcat ggtatttcaa aatccagata
    16981 atcaaatagt tgctactata gtagaagaag acgttgcatt tggacctgag aacttaggta
    17041 tagaaccaaa agaaataaga cgaattgtag aggagtcttt aaaaagtgta ggtatgtatg
    17101 atttaagaga tagacagcct catttgttat caggaggtca aaagcaaaga gttgcaatag
    17161 caggaattat tgctatgagg cctaaatgta taatatttga tgaagcaaca gcaatgttag
    17221 atccatctgg aagaaaagaa gttatgaaaa caataaaaag acttaataag gaagaaaata
    17281 taactgttat acatataacg cactttatgg aagaagcagt agaagctgat agagttgtag
    17341 ttatggaaaa aggaaagaaa atcttagagg gaactcctag agaagtattc agtaaaataa
    17401 agatgttaaa ggaaatcggt ttagatgtac cttgtatgac agagttatct agtttattaa
    17461 tagaagaagg tataaatatt agtagtgata tattaactgt ggatgagatg gtgatggaat
    17521 tatgtcaatt atagtaaaga atttaacaca tatatataat gaagggatgc cttttgcaag
    17581 taaggcactt gatgatgttt cttttgagat taaagataga gattttgttg gtcttatagg
    17641 tcatacaggc tcaggaaaat ctacattaat acaacattta aatggattac taaagccttc
    17701 ctcaggagaa atatttataa atgattttaa tataacagat aaaaacttga atttaactga
    17761 gattagaaaa agagtagggg ttgtatttca atatccagaa taccaattgt ttgaagaaac
    17821 gattgataaa gatatagctt ttggaccctc taatttaggc ttagaggagt ctgagataca
    17881 taacagggta aaagcatcaa tggaagctgt aggacttgat tatgagggat ttaaagacaa
    17941 atctcctttt gaattatctg ggggacaaaa gcgtagagta gcaattgctg gagttatagc
    18001 catgaaccca gaagttctca tattggatga accaactgct ggtcttgacc ctggtggaag
    18061 agatgaaatt tttaacttaa taaaagactt acatgaaaaa aagaatatga ctataatact
    18121 atcatcacat agtatggatg atatggcaaa gttagcaaaa actttaattg ttatgaatca
    18181 tggtagcgta gaatttatgg gaactcctag agaagtgttt aaatcaaatg ctagtaaatt
    18241 aaaagatata ggattagata ttccacaagt tttagaactt gcattgaaat tgagagaaaa
    18301 aggctttgac atcagtgagg atatattgac tttagaagaa gcaaaacagg aaatattaaa
    18361 agttgtgaga ggacgaggat tatgttaaaa gatataacta tagggcaata ctacccaaca
    18421 agttctgcta ttcataaatt agatccaagg ataaagcttg tagcgacaat tgtatttatg
    18481 gtatctatat ttgtagtaaa taaattttgg ccttatatag tagttttatt atgtttatta
    18541 gctatgataa aattggctaa tataccagtc aaatatattg ttaagggtgt taaacctctt
    18601 aaatggatta ttttgtttac atttcttata aatatttttt tcttaccagg tgatgaaata
    18661 tggtcatttg gatttttagc tattacaaaa cagggtctaa gacaagcaat ttttatggca
    18721 ataagattaa tatttttagt agttggtaca tcattgctta ctttaacaac ttcaccaata
    18781 gaattaactg atggaataga gagattgttg aatccattta agaaaattgg tttgccagtt
    18841 catgaacttg caatgatgat gacaattgct ttacgtttta ttcctacatt gttagatgag
    18901 acagacaaaa taatgaaggc tcagatgtct agaggtgcag attttgaaag taagaatctt
    18961 ataaatagag caaagaattt agtaccactt ttggtacctt tatttgtaag tgcatttaga
    19021 agagctgatg aattggctat ggccatggag gccagatgtt acagaggtgg acataatagg
    19081 actaagatga gagagtctgt tatatcaaga agggattata tggcatgtgt atttcaggtt
    19141 gtttatctgg gagcaattat agctactaga tttatagcaa tttaattaat aagttataga
    19201 tataatgagg taaagtatga gaaatataaa aattaaaatc caatacaatg gtaagaatta
    19261 ttgtggatgg caaaagcaac ctgattcttt agggatacaa ggtacaattg aaagggctat
    19321 atatgatata acaaaagaag aaaccagtct tatagggtct ggtagaactg attcaggagt
    19381 tcatgctatt ggtcagattg caaattttaa aattaattca ggtataagta tagaaagtat
    19441 accaatggca ctaaatgcca agttgccaaa agacatatca gttatagaag catgtgaagt
    19501 aaatgatgat tttcactcca gatacagtgc aaaaggtaaa acatataaat atttagtata
    19561 taatagcaag tttagaaatc caatacttag tgagatatca tatcaagtaa aatatgaact
    19621 tgattttgat aaaatgtgtt cagaagcaaa aagtttatta ggaacacatg attttaaagg
    19681 ttttatgagt tctggttcat ctgtaaaaga tacagttaga acgatatatg atattgatat
    19741 aagtaaaaaa gatgacttga ttacttttga gattagtggt aatggttttt tatataacat
    19801 ggtgaggatt attgttggaa cacttgttga tatgggtcgt ggcagaatta acgaaccatt
    19861 tttagatata atacaatcaa aaactaggtc aagatgtgga catacagctc cagcacaagg
    19921 attatttctc aaaaaagttc attattaact tgacacacca ggctacatgt attaaaatat
    19981 atgagaatgt gttaataagt ccacttgccc cggacttgac ataaacggta aaaaaatttt
    20041 atgaaaagta gttaaggagg gacagttatg aaaagttata tagctaagcc agctgatgta
    20101 caaagaaaat ggtacttagt tgatgctgaa ggaaaaacat taggtcgttt agcaacagaa
    20161 attgcgacag tattgagagg taaacataaa ccaacattta ctcctcacgt tgatggtgga
    20221 gattttgttg ttgtagtaaa tgcagaaaaa atagttttaa gtggtaagaa attagatcaa
    20281 aaatattaca gataccatac tggttatgta ggtggattaa aagaaatatc ttacagagat
    20341 atgatggata agaaaccaga agaagttata tcacatgctg taagcggtat gttacctaaa
    20401 aataaattaa gaagcagaat gatgactaga ttaagagtat ttgcaggtgc tgagcacact
    20461 catgcagctc aaaatccaga agttttaaac tttaaataag attaataggt gaaaggagga
    20521 gtttataatg gctaacgttc aatattatgg aactggaaga agaaaaagtt ctgttgctag
    20581 agtaagacta gttgcaggtg aaggaaatat attagtaaat ggaagagcat tagaaaatta
    20641 ttttaattat gagacattaa taagagatgt taaacaacca ttagttttaa ctggtaatga
    20701 aaataaatat gatgttatag taaaagttga aggtggagga ttcactggac aagctggagc
    20761 tataagacat ggaatatcta gagctttatt aaaagctgat ttagatttaa gacctgcttt
    20821 aaagaaagaa ggtttcttaa ctagagatgc aagaatgaag gaaagaaaga aatacggatt
    20881 aaaagcagca agaagagctc cacaattctc aaaaagataa ttacttattt ttttggaaaa
    20941 gcaaaatcct ttatttactg ttattcagaa agtattggta ttttaaaaat gttgggttaa
    21001 gttaattatt gatatataat aaaataataa gatatcttat taggatgttt ttcattaaga
    21061 agaacatcct ttttattttg actatttaat aaaaaacata tgctaataag atttaaattt
    21121 tatttttata atattgtaat ttaaaagttt atataaggtt atatatttta agatattatt
    21181 taacaatata aattctgaat atacgttatc aaagtttata atataaacta agtataattt
    21241 attgtatagt attgaatgtt agataaacat agtgaattaa ataggggcag aaatataata
    21301 tcattacata ataatatatt aataccaata aataaagata tatcaatatt aaaaaaattt
    21361 aaatgtttgt actaatatat ggaatattat agtgttttta taagtataca tatacagggt
    21421 gatgttgtga gaaagtacat aaaacatata atttttagtt ttgcaatgat atgtctagta
    21481 gtagtatcca tatttgaaat taaaaatatt tctgaagatg ttatcaagta tatgccagta
    21541 acaaacaaaa ctataatttt agatgctggt catggaggca ttgatccagg tgcattaaat
    21601 aaggataaga gtacatctga aaaggatatt aacctagcaa taacacttaa gcttagagag
    21661 cttatagaat caagtggtgg ccttgtaata ttaactcgag aagatgacag tagcctttat
    21721 aaagaagaaa ataataaaac tacaagacaa aaatataatg agaatttgaa aaatagaaaa
    21781 gaaataatat ctaattctaa tgccaatatg tttgtctcta tacatcttaa tgcatttgaa
    21841 caatcaaaat actatggagc tcaaactttt tatcctaaag acaaacaaga cagtaaagaa
    21901 ttatcgaagt gtattcaaga agaacttaaa agagtagtag ataagacaaa caacagagaa
    21961 gtcaaaccaa gggatgatat atatcttttg aaagaaaata atattccatc agtactgata
    22021 gaatgtggtt ttttatcaaa tgaaaaagag tgtaaactct taactgatga aacatatcaa
    22081 gaaaaaatag catgggcaat ctacatagga atacaaaaat atttaagttg aaataactat
    22141 aaaaataggt ctaaatatgt aaatagcttg tattaaagca gttaaaatgc attaatatag
    22201 gctattttta ttttgacaaa aaaatattta aaataaaagt taaaaagttg ttgacttaga
    22261 ataatataga tgatattata tatgagtgcc caaaaggagc accaaaataa gac
//
LOCUS       DAEPID010000063        22282 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.063, whole genome shotgun sequence.
ACCESSION   DAEPID010000063 DAEPID010000000
VERSION     DAEPID010000063.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 22282)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 22282)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..22282
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.063"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            824..2494
                     /locus_tag="KR257_002735"
     CDS             824..2494
                     /locus_tag="KR257_002735"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018112769.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GGDEF and EAL domain-containing protein"
                     /protein_id="HBH0031415.1"
                     /translation="MREESNSLSLDHIEIFFELLSQSTEDYIFFWDINRNKFKISSAI
                     FDEFNLSKEIESDLVNCWSKIVYPDDVQIWKDDIQELLHGKKGEHNLEYRLINKYKEI
                     VWISCRGKVYVSDDPKTIFLVGRIKNIGEKNKFDSITGTWNREQFEHKMNYLIKEKIY
                     KNGAMFIMDIDNFKNINEKYGHSYGDKVLRAIATEVLEYLPKDVRLYRLDGDEFAFFY
                     PMCTKETIEKIYEKIQMYTNTQHEIESSKYYCTVTAGVAMYPEDGDNYLDLFKHADIA
                     LDIAKISGKNRIKFFSQELYENKLKVISMQQKLRECVENNFNDFELFFQPQVNAVTKE
                     VIGAEVLLRWHSSTYGEVSPVEFIPILEQSNLIIPVGKWIIKEAVKQCKEWHKINPDF
                     KISVNVSYIQLKEDFFRDFIVECLVEYQLRPEFLILELTENCWIPDINLLNDKFISLK
                     GIGVYIAIDDFGTGYSSLNYLKELSVNIIKIERSFVKNITYNSYEYTFLEYIIKLAHI
                     INLKVCVEGIESYEEYDIVKSLGVDIIQGFLFGRPVSASEFYKFQLSK"
     gene            complement(2616..3350)
                     /gene="pflA"
                     /locus_tag="KR257_002736"
     CDS             complement(2616..3350)
                     /gene="pflA"
                     /locus_tag="KR257_002736"
                     /EC_number="1.97.1.4"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004453705.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pyruvate formate lyase-activating protein"
                     /protein_id="HBH0031416.1"
                     /translation="MIKGKIHSIETFGTVDGPGIRYILFFQGCPLRCKYCHNRDTWDI
                     KSGKEYTVDEIITDALKYTSFMKFSGGGITASGGESTLQPEFLSELFKKAKENDIHTC
                     LDTSGFVDIETIDPVLDNTDLVLLDLKHMVEEKSIDLTGVGMDKALKLARHLESRNIP
                     VWIRHVLVPGITDDIDNLEKLGQFVATLKNVERFELLPYHSMGIHKWESLGIDYELKD
                     VPDATKEDVQKASEIISKFGVKVYNS"
     gene            complement(3510..5741)
                     /gene="pflB"
                     /locus_tag="KR257_002737"
     CDS             complement(3510..5741)
                     /gene="pflB"
                     /locus_tag="KR257_002737"
                     /EC_number="2.3.1.54"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888568.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="formate C-acetyltransferase"
                     /protein_id="HBH0031417.1"
                     /translation="MNAWQGFKTGRWTKEINVREFIQLNYSPYEGNDSFLAGATENTK
                     KLWDEAMVLFKKERENGGTLDVDTKTVSGIAAYAPGYLDKELETIVGLQTDAPLKRAV
                     MPYGGIKMVENSCEAFGYELDPEIKDIFTKYRKTHNQGVFDVYTPEMRAARKSGIITG
                     LPDAYGRGRIIGDYRRVALYGVDALIEDKNEQKKSLEVSCMDEEVIRLREEITEQISA
                     LNELKKMAESYGFDISKPATNSKEAVQWLYFGYLGAVKDQNGAAMSLGRTSTFLDIYF
                     ERDLKAGIVTEEELQEYMDHFVMKLRMVKFLRTPDYNNLFSGDPTWVTECIGGMGIDG
                     RTLVTKNSFRMLNTLYTLGPSPEPNLTVLWSTKLPQGFKDFCSKVSIDTSSVQYENDD
                     LMRAYWGDDYGIACCVSAMRIGKQMQFFGARVNLAKTLLYAINGGVDEKSGVQVGPRF
                     EPITSEYLDYDEVMSKFEPFTDWLATLYVNTLNVIHYMHDKYSYEALEMALHDRDIFR
                     TMACGMAGLSVCADSLSAIKHAKVKTIRNEQGIAVDFEIEGDYPKYGNNDDRVDSIAV
                     ELVESFMNKIRKNKTYRNSYPTQSILTITSNVVYGKKTGNTPDGRRAGAPFAPGANPM
                     HGRDTNGALASLSSVAKLPYEHAQDGISNTFSIVPAALGKDMTERINNLSAMMDGYFA
                     QNAHHLNVNVFDRATLEDAMEHPEEYPQLTIRVSGYAVNFIKLTKEQQLDVINRTFHG
                     KMA"
     gene            6034..7095
                     /locus_tag="KR257_002738"
     CDS             6034..7095
                     /locus_tag="KR257_002738"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418404.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="calcium/sodium antiporter"
                     /protein_id="HBH0031418.1"
                     /translation="MEKRKSIHLHKLNIYLIGGGDRLFITVVLFLVGFLLITKGADIF
                     INCTVEIGKKTNISEIILGATIVSFATTLPEFTVSLLASIDGHTTMSLGNAVGSIICN
                     TGLALGLVVFISPFNVDKKMFFSKSLLLIVSVIVLILLSLDGVITRGDSLLLIIILIF
                     YMVNNYRSVVGKSDTKNRNIKNNTIKDISTKKGKNYRGFSVLEIVKILLLFATGLIMM
                     IIGSQILIESGVIIASFLNIPQGIVSLTIIALGTSLPEIVSSITAIRKNHHEISVGNI
                     LGANILNIVSVIAVSAIPNNIPILSQNRQLDIPFMILLLLIVIIPTLKSNRLSRIQGI
                     LMLFTYFLYISILYFMYII"
     gene            7186..8799
                     /locus_tag="KR257_002739"
     CDS             7186..8799
                     /locus_tag="KR257_002739"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437464.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DEAD/DEAH box helicase"
                     /protein_id="HBH0031419.1"
                     /translation="MNITKFEDLPISEGIKKAIAEMGFEEPSPIQAQSIPAILSGKDV
                     IGQAQTGTGKTAAFSIPILETIDPNNRSLQAVVLCPTRELAIQVSTEIRKLAKYSHGI
                     KTLPIYGGQPIDRQIKSLKSGVQVVIGTPGRTIDHINRKTLKMDNVKMIILDEADEML
                     DMGFREDIEMILSKIPEERQTTFFSATMPRGILELTKRYQKDPEHIKVVRKELTVSNT
                     KQYYIETRSSNKLEVLCRLVDVYDPKLSVVFCNTKRKADELVGDLQARGYFADALHGD
                     LKQTQRDIVMDKFRNGTIDILVATDVAARGIDVDDVECVFNYDLPQDEEYYVHRIGRT
                     GRAGREGMSFTFVFGKEMRKMKDIERYTKSKLIKHNIPTITDVEEKKVGTFFAQVKQT
                     IEEGHLTKQLQWLEGFCNDEDYAMVDIAAALVKLSLGEEMKEEIIEEKPRRERGDRKG
                     GTGAKDGMIRLFINIGRNQRVQAKDIVGAIAGEVGIPGKVVGTIDIYDKYTFVEIPKK
                     DAKTVIEKMKDIKIKGNKINIEKANKKKK"
     gene            9074..11059
                     /locus_tag="KR257_002740"
     CDS             9074..11059
                     /locus_tag="KR257_002740"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860951.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="BglG family transcription antiterminator"
                     /protein_id="HBH0031420.1"
                     /translation="MSMTYMDPRVFLILEMVLEEDTNTLEQFSNVLGVSTRTIRNYIN
                     QINRELKGGIAKIVKNEKGTYSIRIEDESKLIEIVNFNRGKLSNFINLNSPDERINYV
                     LDILTMTNNPITIDDLAEEICIGRTTLIKDLKKADRILAEYDLELKRKPNIGMILVGE
                     EMDIRLLILDRLYENYIDVLENVNQINLVKDYDIECLRDELKKLFKKEELYITEQVLR
                     DVERYIIMSVLRNLNGYKFEKIDKRFEVIRCSDEYTLGLKLKALLEKIFNIVLNEKET
                     IFLTMPLIGRKAPSTKLALSSIKINDSVKEVVDEVTSFLLETSGIDFKEDKKLIENLE
                     YHLYFALNRMRFNIRVKNPLLQEIKERYTFPYSVAKIAAMIIEEKFDLKICDHEIGYI
                     ALHFGGYFEKNSRKVLNVNRVAVVCGTGLGTAQLIRIKIGKILGESVEVNTFSDIEAK
                     ANLDLLKYYDLVFTTVDFKTDLDVPIFRVNALFNEESIKKEIENAILLKNSINLKSIK
                     KIEKNIPFIGKLIEEDKFFILNKSTFMENLEDMLEKLVHKGIIDIEFKKKVLKREKKS
                     STALDNYIALPHSVNTNGENLYLAFGILEKLVIWDTKEIRIIILMIIPDKNVDSTDLI
                     IKSYEEVLEVGRDKKMVEELAKVKSFDEFYKIITKRR"
     gene            11064..11498
                     /locus_tag="KR257_002741"
     CDS             11064..11498
                     /locus_tag="KR257_002741"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437466.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcriptional regulator GutM"
                     /protein_id="HBH0031421.1"
                     /translation="MDPVIFIIASLITVYLLNIFLGYLQLKDFNKNYIELKRKGRVAI
                     GRKKGRISSGTIVLILINDDGVIVETRKMQGVTVLARVKSFEGLVGKSLEYIEKSDLT
                     VYNKLLKKAILDAVKQYITFEKNKCEDTNNLSTDEECRMEVV"
     gene            11527..12087
                     /gene="srlA"
                     /locus_tag="KR257_002742"
     CDS             11527..12087
                     /gene="srlA"
                     /locus_tag="KR257_002742"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418408.1"
                     /note="catalyzes the phosphorylation of incoming sugar
                     substrates along with their translocation across the cell
                     membrane; the IIC domain forms the PTS system
                     translocation channel and contains the specific
                     substrate-binding site; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS glucitol/sorbitol transporter subunit IIC"
                     /protein_id="HBH0031422.1"
                     /translation="MTQFFQVLASGADSFMNLFRAGGQQFVGFVTDIVPLLVALLVTM
                     NAIINFIGTDRVERLAKKCSANIFTRYLILPVLGTFVFANPMTLSLGRFLPEKFKPSY
                     FAAASFSCHTMNGLFPHINPGELFIYLGIANGITTLGFSTADLAVRYLLVGIVANFIK
                     GVVTDYTTKFVEKQQGIALNSDIKIG"
     gene            12151..12519
                     /locus_tag="KR257_002743"
     CDS             12151..12519
                     /locus_tag="KR257_002743"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418409.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sorbose transporter subunit IIB"
                     /protein_id="HBH0031423.1"
                     /translation="MAFNKVKIVKGSGGWGGPLIIEPTEKKNKVVYVTGGAKPETAVK
                     IAELTGCELIDGFSQGVKDDEIACVIINCGGTLRCGIYPQKKIPTINIMKTGKSGPLA
                     MFIKEDIYVSGVKPTNVEQL"
     gene            12544..13110
                     /locus_tag="KR257_002744"
     CDS             12544..13110
                     /locus_tag="KR257_002744"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003374365.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS glucitol/sorbitol transporter subunit IIB"
                     /protein_id="HBH0031424.1"
                     /translation="MAYDTKKKISEQSQGIVAKIGIALGNVTSTLFQAGRDTIDTLIH
                     TILPFMAFVAVLIGIINQSGIGNWVANLLTPLIGNVGGLVVLSIICSFPLLSPFLGPG
                     AVIAQIVGVLVGTEIGKGNIPPSLALPALFAINSQAACDFIPVGLGLAEAEPDTVQVG
                     VPSVLYSRFLTGAPTVLLAWLASFGLYK"
     gene            13151..13516
                     /locus_tag="KR257_002745"
     CDS             13151..13516
                     /locus_tag="KR257_002745"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437468.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS glucitol/sorbitol transporter subunit IIA"
                     /protein_id="HBH0031425.1"
                     /translation="MELIYSTQINKIGDNANEFLQHNMFVTFKDNAPQELENYCYIHS
                     ENNLVKEILTDDVLSINNVDYKITSVGELVNQNLSELGHITFKFTGEKDGAIGGTLYL
                     EEKEIAPIGVGTILKIIRK"
     gene            13617..14390
                     /gene="srlD"
                     /locus_tag="KR257_002746"
     CDS             13617..14390
                     /gene="srlD"
                     /locus_tag="KR257_002746"
                     /EC_number="1.1.1.140"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009905113.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sorbitol-6-phosphate dehydrogenase"
                     /protein_id="HBH0031426.1"
                     /translation="MRKVALVVGGGRSLGEYLSKHLAKVGYDVAIADLNEDNAKKVAE
                     EIKTEFGCKSVGYSCNAIDERQVISTVKAIENDFDRIDLLVYNAGVAVSKKITDFGYK
                     DFKFIVDVNLNGYFLFAREVSKVMIAKGIEGRIIQINSKSGRVGSKHNSGYSAGKFAG
                     VGLTQSLALDLAEHKITVNALMLGNLLDSDMFESLIPQYAVKLGIPESEVKQVYIDKV
                     PLKRGCRFIDVANMLTFYASKEAEYCTGQSINITGGQVM"
     gene            14739..17177
                     /locus_tag="KR257_002747"
     CDS             14739..17177
                     /locus_tag="KR257_002747"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892781.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="molybdopterin-dependent oxidoreductase"
                     /protein_id="HBH0031427.1"
                     /translation="MDIIKKLSHGCTLDCHDCCKFNVYTKGNNVVKIEGDKNHPYTKG
                     FICKKGMAHLDRLNHKDRIKTPMLKVDGVWKEISFDKAIEIMAEKLTYYKEKYTSKSV
                     MHYDQYGSGSVLKYIGDIFFNFYGGVSRHKGGPCWSAGMHAQKYDFGVAKSHAIEDML
                     NSKSIFVWGKNPAYTTIHTMQIIKKAKEKGIKIVVIDPIYTKTAQIADKYVQVNPGTD
                     GALAIAMAKIIVEDKLYDEEYINSYVIGFEEYKKYLSSLELSFLIDECGVKENDIREL
                     VDLYTNKYSSINVGYGLQKYKNGGNTIRAIDALGAITGQIGFSGGGVNYANKVYPSVI
                     NSDPYNSQSYGEDREFYVSNISKFIEESLKNTSNKVNYASDELDMALHKVNYISDELD
                     TTSNKVNYVSDELDMALHKVNYVSDELDTTSNKVNYVSDELDMALHKVNGVSDELDMA
                     LHKVNCVSDELDMTSNKVNYVSDELDMTSNKVNYVLDELDITSNKTDYISNELYNLSN
                     KSIKDNIPIKMAVITKSNMLNQLPDLVELERVFSKIEFKVCFDMFITDTVTLCDMFIP
                     CTNTLESEDIIYSSMTNPYITYNERAVKPAHKLMDEYYFFMELAKKMGLNDYPFVEKR
                     TYLEKVIEPLKRFDKNLDIEKLKNNYFTIHNPVAWEDKKFETPSGKYELYSESIKNLG
                     ISPTPVYISNKYKEIEDKNISFRLLTNHHADTLFSQHFMDKKSIAQAYINQRMAKKVG
                     IEEKDIVILRSKKAKINVQINIDDGVGNYIVKMYVGWWKKHGNPNSLTDTGISDFGGQ
                     VTYNESMVEIIRQN"
     gene            17265..17600
                     /gene="spoIIAA"
                     /locus_tag="KR257_002748"
     CDS             17265..17600
                     /gene="spoIIAA"
                     /locus_tag="KR257_002748"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418414.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="anti-sigma F factor antagonist"
                     /protein_id="HBH0031428.1"
                     /translation="MVNYSLEHKNLYIEFMCSELDHHVANEIREEIDNLLSVNQVKNV
                     VFNFENINFMDSSGIGVIIGRYKKISNEGGRVSVINISSRVKKIFDLSGLNKIIGIYD
                     TYEEALSSL"
     gene            17614..18042
                     /locus_tag="KR257_002749"
     CDS             17614..18042
                     /locus_tag="KR257_002749"
                     /EC_number="2.7.11.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418415.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="anti-sigma F factor"
                     /protein_id="HBH0031429.1"
                     /translation="MNNIMEVKFSAISENESLARVIVASFAAKLDPTVDELVDIKTAV
                     SEAVTNAIIHGYEEDSSKFVFLRCEIEGNTIKIIVEDEGYGIENVEKAMEPLYTSKPE
                     LDRSGMGFTVMKSFMDDVEVSSVKDNGTRIEMTKKINVPK"
     gene            18065..18829
                     /gene="sigF"
                     /locus_tag="KR257_002750"
     CDS             18065..18829
                     /gene="sigF"
                     /locus_tag="KR257_002750"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418417.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RNA polymerase sporulation sigma factor SigF"
                     /protein_id="HBH0031430.1"
                     /translation="MEVTVAREEKKPLLSHEETLELIEKVQNGDEEAKEILISSNLGL
                     VRSVVSRFLNIGYDREDLFQLGSIGLIKSIYKFDPKFNVKFSTYAVPMILGEIKRYLR
                     DDGMIKVSRSLKQIAVKAKMESEALTKKLGREPSIEELAKAIDVEKEDLVMAMEANFN
                     VEYLQGVIHEEEGSPICLIDKISMKGESEEEKVVDNILLKDILGRLDKRERQIIVLRY
                     FEDMTQSEIGEMLNISQVQVSRIEKKVLSKLKEYIS"
     gene            19109..19546
                     /gene="spoVAC"
                     /locus_tag="KR257_002751"
     CDS             19109..19546
                     /gene="spoVAC"
                     /locus_tag="KR257_002751"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418420.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="stage V sporulation protein AC"
                     /protein_id="HBH0031431.1"
                     /translation="MDKNYKKYVDQISPKPTYLKNYTLAFIVGGIICMIGQAINDLYM
                     KVGGLDKLGASSATSITLIFIGAFLTGLGVYDLIGKRAGAGSIIPITGFANSIVSPAM
                     EYKREGYVLGVGANLFKIAGPVLVYGIGSSILCGIIYYIFKMF"
     gene            19713..20726
                     /gene="spoVAD"
                     /locus_tag="KR257_002752"
     CDS             19713..20726
                     /gene="spoVAD"
                     /locus_tag="KR257_002752"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418421.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="stage V sporulation protein AD"
                     /protein_id="HBH0031432.1"
                     /translation="MKNKRIGKRTVKLENKPTIISTGTIVGPKEGEGPLKDYFDMIMT
                     DDLYGEKTWELAESKMVETASQQAIQKAGKKLSDVNYMLGGDLINQIVPASFAARELA
                     IPFLGIYGACSTMAEGLCIGSMLIDGGFADLVLSGTSSHYCTAERQFRFPLELGNQKP
                     MTAQWTVTGAGSVLLAPNGDGPKVKYVTVGKVIDEGIDDGNNMGPAMAPAAIDTIYSY
                     FEDTNDDPNSFDIIATGDLGTLGKQIAEDFLKEKGVDISKVYTDCGIEMFNLKEQDVH
                     CGGSGCGCSATVFAGYIYDKLRKKEFNKVMLVSTGALLSPTSTLQKQTIPCVAHAVVI
                     VNE"
     gene            20740..21102
                     /gene="spoVAE"
                     /locus_tag="KR257_002753"
     CDS             20740..21102
                     /gene="spoVAE"
                     /locus_tag="KR257_002753"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902150.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="stage V sporulation protein AE"
                     /protein_id="HBH0031433.1"
                     /translation="MLMDYVRVFIVGGIICLIAQVMMDYFKMQTPYVMVTYVTTGVVL
                     TFLGLYEPLVKFAAAGATVPIIGFGYSLATGVIKSIQSDGFLGIFLGGTTATAGGIAA
                     AIFFGYIMSVVFTPKAKP"
     gene            21285..>22282
                     /locus_tag="KR257_002754"
     CDS             21285..>22282
                     /locus_tag="KR257_002754"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888571.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LacI family DNA-binding transcriptional
                     regulator"
                     /protein_id="HBH0031434.1"
                     /translation="MVTIKDIARNLGISYSTVSRCLNNNPNVSEKTKKKVVEEANRLG
                     FHFNVNARNLAKKETNRIGVIFSNNFNHQDTRKFFSDIMDSSINSIETNKYDFIIQPN
                     NNISGDSNVYKMVNGQMVDGLVIVSQSIKKEEYDFLKDNNFPHVFIYFKPSFIGEVDN
                     FFWDDNVYGGYIATKHLIDHGHKDIITVTSDDKSSKMHEDRTKGYLNAMEEANLKTEV
                     IKSKMDFESQVEFLEKYIDKIKKASAIFVQQDVPAISIIQELKTTYGINVPEDISIIG
                     YNNIELISYFRSHLSTIDDPREQVIKNGVDSLVNIINKKSTEHIPRKLYPRLIIRN"
BASE COUNT         8690 a         2508 c         3872 g         7212 t
ORIGIN      
        1 aattaaaata aaaaatatta ttttatattt ataaacattg acattctaat tttgtagtgt
       61 aatcgtattt tttattaatt cttacaaaat caatgaaaat aagtatatcc attttaaagt
      121 acataaattt aaaaatccag aaaaatatac ttaaattatg taagtaaaag aggggttgaa
      181 tcagttgaaa atgtaatatt agcaaatagt acatcaatcc tatataccct gtaagcaact
      241 ctattttcat gtactaaaaa tgtacctatt ttattaactg aaaagaataa attaaatgta
      301 agtacataag aagatagaaa aaattaaaaa caaaaaatat ttatataaat aaatataaaa
      361 aatgatataa tccctattaa aaaatttata gatgatgaag aaatatcaaa atcttatatt
      421 ataggaagag acacttcttt gccaaaatct atagaaaaac aataccaaat ccaaagagaa
      481 taggcggaga aaaaaataaa ataaattcaa gagtaataga aaagttttat agaataaaga
      541 actgataact ctttatataa cgaaaaatag aattttaaga gaaaatgatt taataactga
      601 tttaacatgg tgttttagca ggtaaaaata aatcaccagt aatgattata gaaaaattac
      661 tttatgaatc tcaaaaaact tagttaagag taagagattt gataagataa ctaaagttgg
      721 ggaaatgtgt ttgatgagac aaaaaattag taaaatagta taatctaaat aaggatattt
      781 tgttgattaa actacactaa tagtaatatt gtagggggaa aagatgagag aagaatcgaa
      841 ctctttaagt ttagaccata tagaaatttt ctttgaactt ttatctcaaa gtacagaaga
      901 ttatatattt ttttgggata taaataggaa taaatttaaa atttcttcag caatttttga
      961 tgaatttaac ttaagtaaag agatagaatc tgatttggtc aattgttgga gtaaaattgt
     1021 ttatccagat gatgttcaaa tatggaaaga tgatatacaa gaattactac atggaaaaaa
     1081 aggtgagcac aatttagaat ataggttgat taataaatat aaagaaatag tatggatttc
     1141 ttgtagaggt aaagtttatg tgtcggatga cccaaaaact atatttctag tcgggagaat
     1201 aaagaatatt ggtgaaaaaa ataaatttga ttctatcaca ggaacgtgga atagagaaca
     1261 atttgaacat aaaatgaatt atcttataaa agagaaaatt tataaaaatg gtgctatgtt
     1321 tattatggat attgataatt ttaaaaatat aaatgaaaaa tatggacatt cttatggtga
     1381 caaagtgttg cgtgcaattg ctactgaagt actggaatat cttccaaaag atgtaagatt
     1441 gtataggtta gatggagatg aatttgcatt tttttaccct atgtgtacta aagaaactat
     1501 agagaaaata tatgaaaaga tacagatgta tacaaatact cagcatgaaa ttgaatcaag
     1561 taagtactat tgcacagtga ctgcaggcgt tgctatgtat ccagaagatg gagataatta
     1621 tttagattta tttaaacatg ctgatattgc attggatata gcaaaaatta gtggtaaaaa
     1681 tagaattaag tttttttcac aagagctcta tgaaaataaa ctaaaggtaa tttcaatgca
     1741 acaaaaacta agagagtgcg ttgaaaataa ttttaatgac tttgagctgt tttttcaacc
     1801 ccaggtaaat gctgttacaa aagaggtaat aggggcagag gtacttttaa gatggcattc
     1861 gagtacttat ggagaagtat ctcctgttga atttatacca atactagaac agagtaattt
     1921 aattatacca gttgggaagt ggattataaa agaagctgta aaacagtgta aagaatggca
     1981 taaaataaat ccagacttta aaatatctgt aaatgtatcg tatattcagt taaaggaaga
     2041 tttttttaga gattttatag tagaatgttt agtagagtat caattaagac ctgaattttt
     2101 aattttggaa ttaacagaga attgttggat accagatata aatttactaa atgataaatt
     2161 tattagttta aagggtatag gagtatatat tgcaatagat gactttggta caggatattc
     2221 atctttaaat taccttaaag aactgtctgt taatataata aaaattgaaa gaagttttgt
     2281 taagaatatt acatataata gttatgaata tacttttctt gaatatatta ttaaattagc
     2341 tcatattata aatttaaaag tttgtgttga gggaatagag tcttatgaag agtatgatat
     2401 agtaaaaagc ttaggggtag atattattca gggtttttta tttggaagac ctgtaagtgc
     2461 ctctgaattt tataaatttc agctatcaaa gtgatgtata taaaatgaga tatatagtat
     2521 ataaaaatag ggcaaagtgg aagttttgaa gtttattaaa aatttacact ttaccctatt
     2581 ttgttatgtc ttctataaag gattaatata ctacactaac tattatatac tttcactcca
     2641 aatttagaga ttatttcact agctttttgg acatcttcct tagtggcatc aggaacatct
     2701 tttagttcat aatcgatacc taaactttcc catttgtgta ttcccataga atggtatggt
     2761 agcaattcaa atctttctac atttttcaat gtagctacaa attgacctag tttttctaaa
     2821 ttatctatat catcagtaat gccaggaact aaaacatgtc ttatccatac aggaatattt
     2881 cttgattcta agtgtctagc aagttttaat gccttatcca taccaacacc agtcaaatca
     2941 atagattttt cctcaaccat atgttttaaa tcaagtaaaa ccaaatcagt attatctaaa
     3001 actgggtcta tagtttctat atctacaaat ccagatgtat ccaagcaagt gtgtatatca
     3061 ttttcttttg cttttttaaa taattcactt aaaaattctg gttgaagagt ggattcacca
     3121 ccagaggcag ttatacctcc accagaaaac ttcataaaag aagtatactt aagagcatcc
     3181 gttattattt catcaactgt gtattctttt cctgatttaa tatcccatgt atccctgtta
     3241 tgacagtatt tgcatctaag aggacacccc tgaaaaaata atatatatct tattcctggt
     3301 ccatctacag taccaaacgt ttctatagaa tgtatctttc ccttaatcat agagttcacc
     3361 tcacaatata ttttaataac cttatcaata gttataatat ttctctaaaa aaggccatct
     3421 tataccagaa ataattcaaa tataagatag ccttttattt ttatttttta cacagtagta
     3481 atcttagtta aagtataaaa atttaaagac taagccattt taccgtggaa tgttctgttt
     3541 ataacatcta attgttgctc tttagttaat tttatgaagt taactgcata tccagatact
     3601 cttatagtta attgtggata ttcttctgga tgttccatag catcttctaa agtagctcta
     3661 tcaaatacat ttacatttaa gtgatgagca ttttgagcga agtatccatc catcattgca
     3721 gaaagattgt ttattctttc agtcatatct tttcctaaag cagcaggtac tatagagaaa
     3781 gtattagata taccatcttg agcatgttca tatggtaatt tagcaactga agataatgaa
     3841 gctaaagcac cattagtatc tctaccatgc attgggttag caccaggagc aaatggagca
     3901 ccagctcttc taccatctgg tgtattacca gttttcttac cataaacaac atttgaagtt
     3961 attgtaagta tagattgagt aggataagaa tttctataag ttttattctt tcttatttta
     4021 ttcataaagc tttcaactaa ctctacagct atactatcaa ctctatcatc attatttccg
     4081 tattttggat aatctccttc tatttcaaaa tcaacagcta ttccttgttc atttctaata
     4141 gttttaacct tagcatgttt tatagcagat aatgagtctg cacaaactga taatccagcc
     4201 ataccacaag ccatagttct aaatatatct ctatcatgta atgccatttc taatgcttca
     4261 taagaatatt tatcatgcat ataatgtatt acatttaaag tatttacata taatgttgct
     4321 aaccaatcag tgaatggttc aaatttactc ataacttcat cataatctaa gtactcagaa
     4381 gttataggtt caaatcttgg tccaacttga acaccagatt tctcatctac accaccattt
     4441 atagcgtata ataaagtttt agctaagtta actctagctc caaagaactg catttgttta
     4501 ccaattctca ttgcagatac acaacaagct ataccatagt catctcccca gtatgctctc
     4561 attaaatcat cattttcata ctgtactgaa cttgtatcta tagatacttt agaacagaaa
     4621 tctttgaatc cttgaggtaa tttagttgac catagaactg ttaagtttgg ttctggagaa
     4681 ggccctaatg tatatagagt atttaacatt ctaaatgagt ttttagtaac taatgttcta
     4741 ccatctattc ccatacctcc tatacactca gttacccaag ttgggtctcc agagaataag
     4801 ttattgtaat caggagttct taggaactta accattctta atttcataac aaaatggtcc
     4861 atatactctt gtaattcttc ttctgttacg attccagctt ttaaatctct ttcaaagtat
     4921 atatctaaga aagtagatgt tctacctaaa gacattgcag caccattttg gtctttaaca
     4981 gcacctaaat aaccaaagta taaccattgt acagcttctt ttgagttagt tgctggtttt
     5041 gatatatcaa atccataaga ttcagccatt tttttaagtt catttaaagc tgatatttgc
     5101 tcagttattt cttctcttaa tctgataact tcctcatcca tgcaagaaac ttctaatgat
     5161 ttcttttgct catttttatc ttctattaaa gcatcaacac catatagagc aactcttctg
     5221 tagtcaccaa ttattctacc tctaccataa gcatctggaa gacctgttat tataccagat
     5281 tttctagcag ctctcatttc tggagtataa acatcaaaaa ctccttggtt gtgtgttttt
     5341 ctgtatttag taaatatatc ttttatttct gggtctaatt catatccaaa agcttcgcat
     5401 gaattttcaa ccatctttat accaccatat ggcatgacag ctctttttaa aggggcatcc
     5461 gtttgtaacc caactattgt ttctaattct ttatctaaat atcctggagc atatgcagct
     5521 attccagaaa cagtttttgt atcaacatct aaagtaccac cattttctct ttctttttta
     5581 aataggacca ttgcttcgtc ccataatttt ttagtatttt cagtagcacc agctaagaaa
     5641 gagtcatttc cctcatatgg agaatagttt aattgtataa actctctaac atttatttct
     5701 ttagtccatc ttcctgtttt aaatccttgc catgcattca ttaagtattt cctccttaga
     5761 tttaaatgat aaataatact attaaaatta atttttatat acttaattta ttttatatat
     5821 ttttttaaaa atatattttc taatataata atatcatatt attcgtatcc tgtatacata
     5881 aaaaataaaa aattgtcgct ttaaagtata aaacagatta tatgttaata atgtggtgaa
     5941 attataccca tatataaata aaataaaaca aataaatagc taattaagga gaaaatattt
     6001 tttatttttt gtttaggata aataaatttt attatggaaa aaagaaaaag catacatctt
     6061 cacaaattga atatttattt aataggggga ggtgatagat tgtttatcac agtggtatta
     6121 tttttagtag gtttcctatt aattactaaa ggcgcagata tctttataaa ttgcactgta
     6181 gagataggta aaaaaacgaa tatatcagaa attatacttg gagctactat agttagtttt
     6241 gcaacaacat tacctgaatt tacagtgtct ctacttgctt ctattgatgg tcatactact
     6301 atgagtttag gaaatgcagt tggttctata atatgtaata caggattagc attagggttg
     6361 gttgttttta taagtccatt taatgtagat aaaaaaatgt ttttttctaa gtctttacta
     6421 ttaatagtat ccgttatagt tttaatttta ttgagtttag atggagttat aacaagaggt
     6481 gattcattat tacttataat aatattaatc ttttatatgg ttaataatta tagaagtgtc
     6541 gttggaaaat ctgatactaa aaatagaaat attaaaaata acactattaa agacatatct
     6601 actaaaaaag ggaaaaatta tagaggtttt tccgtattag aaattgtaaa aatactatta
     6661 ctttttgcta caggattgat aatgatgata ataggttcac aaatccttat agagagtgga
     6721 gtaataatag ctagtttttt aaatatacct caaggtatag taagtttaac tataatagca
     6781 cttggaactt ctctgccaga gatagtttcg tcgattactg ctataagaaa aaatcatcat
     6841 gaaatatcag taggaaatat tttgggtgca aacatattga atatagtatc agtaatagct
     6901 gtatcagcaa taccaaataa cataccaata ctatctcaaa atagacaatt ggatatacca
     6961 ttcatgatat tattattatt aatagtaata ataccaacac ttaaatctaa tagacttagt
     7021 agaatacaag gtatattgat gttattcaca tattttctgt acatatcaat tttgtatttc
     7081 atgtatatta tttaactata ctgtttaaaa tattaattgc agaatatcct aaaaaagtat
     7141 ataatggata ggttaagatt aattgataac ggagaggaat aatatatgaa tataacaaag
     7201 tttgaagatt taccaataag tgagggaata aaaaaagcta tagctgaaat ggggtttgaa
     7261 gaaccatctc ctatacaagc acagtctata cctgcgattt tgtcaggtaa agacgttata
     7321 ggacaagctc aaactggtac gggaaaaaca gctgctttta gtatccctat actagaaaca
     7381 atagacccaa ataatagaag tttacaagct gtagtgcttt gtccaacaag agaactggca
     7441 atacaagtat caacagaaat aagaaagtta gctaagtatt cgcacggaat aaagacatta
     7501 cctatatatg gtggtcagcc aatagataga caaataaaat ctctaaagag tggtgtgcaa
     7561 gttgtaatag gtacaccagg acgtacaata gaccatatca atcgtaaaac attaaagatg
     7621 gataatgtaa aaatgattat attagatgaa gcagatgaaa tgctagatat gggatttaga
     7681 gaagatatag aaatgatttt aagtaagatt ccagaagaaa gacaaacaac tttcttttca
     7741 gctactatgc caagaggaat tttggaatta actaagagat atcaaaaaga cccagagcat
     7801 ataaaagttg ttagaaaaga acttacagtt tcaaatacaa agcaatacta tatagaaact
     7861 aggtcatcaa ataaattaga agtattatgt agattagtag atgtatatga ccctaaacta
     7921 tctgttgttt tctgtaatac taagagaaaa gcagacgaat tggtaggaga tttacaagca
     7981 agaggatatt ttgcagatgc attacatggt gacttaaaac agactcaaag agatatagta
     8041 atggataagt ttagaaatgg tacaatagat atacttgttg ctactgatgt tgcagctaga
     8101 ggtatagatg ttgatgatgt tgaatgtgta ttcaactatg acttaccaca agatgaagag
     8161 tattacgttc atagaattgg tagaactggt cgtgctggta gagaaggtat gtcatttact
     8221 tttgtatttg gaaaagaaat gagaaagatg aaagatatag aaagatatac taaatctaaa
     8281 ctaataaagc ataatatacc aacaataact gatgttgaag agaaaaaagt aggtactttc
     8341 tttgcacaag ttaaacaaac tatagaagaa ggtcacttaa ctaaacaatt acaatggtta
     8401 gaaggtttct gtaatgatga agattatgca atggttgata tagctgctgc acttgtaaaa
     8461 ctatctctag gtgaagaaat gaaagaagaa ataatagaag aaaaacctag aagagagcgt
     8521 ggagatagaa aaggtggtac tggagctaaa gatggtatga ttagattatt tatcaatatt
     8581 ggtagaaatc aaagagtaca agcaaaagat atagttggtg ccatagctgg agaagttgga
     8641 ataccaggta aagtagtagg tactatagat atatatgata agtatacttt tgttgaaata
     8701 cctaaaaaag atgcaaaaac agtaattgaa aagatgaaag atattaagat aaaaggtaat
     8761 aagattaata tagaaaaagc aaacaagaag aaaaaataac gtatagtata caaaactata
     8821 attagaaaat atataaaata atatattgga tatttaaaaa gcctgatgtg ttttcaaaac
     8881 agatagtaga taatctgtaa gagttaacag cataaggctt ttcttgtttt atatgatgtt
     8941 ataattttcc agattgttgt gaaaaatgta tattagttcc tttttttcaa atctgatttg
     9001 aaaaagagaa tattaattat ctatatagtt tagattataa taaaaaatgt aagataacaa
     9061 aggggagaaa aagatgtcaa tgacttatat ggaccctagg gtttttttga ttttagaaat
     9121 ggtgttagaa gaagacacaa atactctaga acaattttca aatgttttgg gtgttagtac
     9181 taggactatc agaaactata taaaccagat taatcgagaa ttaaaaggtg gtattgctaa
     9241 aatagttaaa aatgaaaaag gtacatatag tataagaatt gaggatgaaa gtaaattaat
     9301 tgagattgta aattttaata gaggaaagct atcaaatttt ataaatttaa attcacctga
     9361 tgaaagaata aattatgttc ttgatatttt aactatgacc aacaatccaa ttaccataga
     9421 tgatttggct gaagagatat gtataggaag aacaacatta ataaaggatt taaaaaaagc
     9481 agacagaatt ttagctgaat atgatttaga attaaaaagg aagccaaata taggtatgat
     9541 tttagttggt gaagaaatgg atataagatt attaatcctt gatagattgt atgaaaatta
     9601 tattgatgtc ttggaaaacg ttaatcagat aaatttagtt aaagattatg atattgaatg
     9661 tcttagagat gaattaaaaa agttatttaa aaaagaagaa ctctacataa cagaacaggt
     9721 cttgagagat gttgaaagat atataatcat gtctgtctta agaaatctaa atgggtacaa
     9781 atttgaaaag atagataaga gatttgaagt gataagatgt tcagatgaat atactttagg
     9841 attaaagctc aaagctttat tggaaaagat atttaatata gttttaaatg aaaaagaaac
     9901 catatttttg acaatgccat taataggtag aaaagctcct agtacaaaat tagcacttag
     9961 cagtataaag ataaatgata gcgtaaagga agttgtagat gaagtaacta gttttttatt
    10021 agagacctca gggattgatt ttaaagaaga taaaaagctt atagaaaatt tggaatatca
    10081 cttgtatttt gcacttaata gaatgagatt caacataagg gtaaaaaatc ctcttttaca
    10141 agaaataaag gaaagatata catttccata tagtgttgca aagatagctg caatgataat
    10201 tgaggaaaag tttgacttga aaatatgtga ccacgaaata ggatatatag cattacattt
    10261 tggaggttat tttgaaaaaa attcaagaaa agttctaaat gtaaataggg tagctgttgt
    10321 ttgtggaaca ggtcttggga ctgcacaact tattagaata aagataggaa aaatacttgg
    10381 agaaagtgta gaagtaaata ctttttctga tatagaagct aaagctaatt tagatttatt
    10441 aaagtattat gatttagtat ttacaacagt agatttcaaa acagacttag atgttccaat
    10501 ttttagagta aatgcgttat ttaatgaaga aagtataaag aaagagatag aaaatgcaat
    10561 acttttgaaa aatagtataa atcttaagtc tataaaaaag attgaaaaaa atatcccttt
    10621 tataggtaaa ttaattgaag aggataagtt ctttatattg aataagagta cgtttatgga
    10681 aaatttagaa gatatgttag aaaaattagt tcataaagga attattgata tagagttcaa
    10741 aaaaaaggta ttaaaaagag aaaagaaatc ttcaacagca ttagataatt atatagcatt
    10801 gcctcactca gttaatacta atggggaaaa tctttatctg gcatttggaa tattagaaaa
    10861 actagtgatt tgggatacaa aggaaattag aataataata ttgatgataa ttccagataa
    10921 gaatgtagat agcacagacc tgataataaa aagttatgaa gaagtacttg aagtagggag
    10981 agataaaaag atggtagaag aacttgctaa ggtaaaatca tttgatgaat tttataaaat
    11041 aattaccaag aggaggtaat aatatggacc cagtaatttt tattatagca tcacttatta
    11101 cagtgtattt attaaatatt tttcttggat acttacagct taaagatttt aataaaaatt
    11161 atattgaact aaaaagaaaa ggaagagtgg caattggcag aaaaaaagga agaatttcat
    11221 caggtacaat tgtgttgata cttataaatg atgatggtgt gattgtcgag actagaaaaa
    11281 tgcaaggtgt tacagtattg gcaagagtaa agtcatttga aggtttggta ggaaagagct
    11341 tagagtatat agaaaaatca gatttaactg tttacaataa actacttaaa aaagcaatac
    11401 tagatgcagt caaacagtac ataacatttg agaaaaataa atgtgaagat acaaataatc
    11461 tgagtactga tgaagagtgt aggatggaag tagtttaaaa aaatatattt ataaggagga
    11521 gttaatatga cgcaattttt tcaagtatta gcaagtggtg cagatagttt tatgaattta
    11581 tttagggcag gtgggcaaca atttgtaggt tttgtaacag atatagtacc acttttagta
    11641 gcattattag ttacaatgaa tgcaattatc aactttattg gtacagatag agtcgagaga
    11701 cttgcaaaaa aatgttctgc aaatatattt actagatatt tgatattacc agtccttggt
    11761 acatttgtat ttgcaaaccc aatgacacta tcattaggaa gattcttgcc agaaaagttt
    11821 aaacctagtt actttgcagc agcaagcttt tcatgccata caatgaatgg attattccca
    11881 catatcaatc caggtgaact atttatatat ctaggaattg caaatggtat aacaactttg
    11941 ggattctcaa cagcagattt agcagttaga tatttgttag tgggtatagt tgcaaacttt
    12001 attaaaggtg tagttactga ctatacaaca aaatttgtag agaaacaaca aggaatagca
    12061 ttaaattcag atataaagat tggataatta ctttaaggta taaataaatt tttcaaataa
    12121 aaagatagtg tatagaggag gataaattat atggcattta acaaagttaa aatagtaaaa
    12181 ggttctggag gatggggtgg accattgata atagaaccaa cagaaaagaa gaataaggta
    12241 gtatatgtga ctgggggagc aaagccagaa actgcagtaa aaatagctga acttacagga
    12301 tgtgagttaa tagatggatt ttcacagggt gttaaagatg atgaaatcgc atgtgtaata
    12361 ataaattgtg gtggaacatt gagatgtggt atatatcctc aaaagaaaat accgactata
    12421 aatataatga aaacaggaaa aagtggacca ttagcaatgt ttataaaaga agatatatat
    12481 gtttcagggg taaaaccaac aaatgtagag cagttataat tgaggtagta ggagggaaga
    12541 aatatggctt atgatactaa aaagaagata agtgagcaga gtcaaggaat tgttgcaaaa
    12601 ataggtatag cactaggaaa tgtgacaagt actctttttc aagctggtag ggatactata
    12661 gatacattaa tacatactat actgcctttt atggctttcg ttgcagtcct aataggtata
    12721 ataaatcaat cgggtatagg aaattgggta gccaatttac ttactccatt aatcggaaat
    12781 gttggaggtt tagttgtctt atcaataata tgttcatttc cgttgttgtc tccgtttctt
    12841 ggaccaggag ctgttatagc tcagatagtg ggggtattgg ttggtacaga aataggaaaa
    12901 ggaaatattc caccaagttt agcattacca gcattgtttg caataaactc acaagcagct
    12961 tgtgacttta taccagtagg tcttggtctt gcagaagctg aacctgatac agttcaagta
    13021 ggagttccgt cagttttata ttctagattt ttaacaggtg caccaactgt tctattagca
    13081 tggttagcaa gctttgggtt atataaatag aagaatactt tataaataat tagagagagg
    13141 ttcagttgat atggaattaa tatacagtac tcaaataaat aaaataggag ataatgcaaa
    13201 tgaattttta caacataata tgtttgtaac tttcaaagat aatgctcctc aagagttaga
    13261 aaattactgt tatatacatt ctgaaaataa tttagtaaaa gaaatactta cggatgatgt
    13321 gctatcaata aataatgttg attacaaaat tacttctgtt ggtgagttag taaaccaaaa
    13381 tctttcagaa ttaggtcata taacatttaa gtttacaggt gaaaaagatg gagcaattgg
    13441 aggaacctta tatcttgaag aaaaagaaat agcacctatt ggcgtaggta ctatactaaa
    13501 aataattaga aaataaaatt taaaacgaat ctaatcatat tataagtaaa ttatagataa
    13561 aagtcaattt aactaatcaa gttaactttt aatgtgataa aaaaggggaa atgaaaatga
    13621 gaaaagtggc tttagtcgtt ggaggaggaa gaagtttagg tgaatattta tctaaacatt
    13681 tagctaaagt aggttatgat gttgctattg cagatttaaa tgaagacaac gcaaaaaaag
    13741 tagctgaaga aataaaaact gaatttggtt gtaaatctgt aggatatagt tgtaatgcca
    13801 tagatgaaag acaggttata agtactgtca aagctattga aaatgatttt gatagaatag
    13861 atttattagt gtacaatgca ggagtggctg taagtaaaaa aataactgat tttggataca
    13921 aagattttaa atttattgta gacgtaaatt taaatgggta ctttctattt gcaagagaag
    13981 tatctaaagt catgatagca aaaggtattg agggtagaat aatacagata aattcaaaat
    14041 caggtagagt gggaagcaag cataattcag gatattcagc aggtaaattt gctggagtag
    14101 gacttactca aagtttagcg ctagatttgg cagaacataa gataactgta aatgcactga
    14161 tgctcggtaa tttacttgat tctgatatgt ttgaaagttt aattcctcaa tatgcagtaa
    14221 aattgggaat acctgaatca gaagtcaagc aagtttatat agataaagta cctttaaaaa
    14281 gagggtgtag atttatagat gttgcaaata tgcttacatt ttatgcttca aaggaagctg
    14341 aatactgcac tggtcaatct ataaatatta ctggtggaca agttatgtaa ggtttttatg
    14401 gagtgtctca agatgaactc tttagttcat gaggcacttt tttgtataaa attaaatata
    14461 ttttcagcat ttaaacaatg aaaaagaggt ttatctttat tttgagatag cctcattttt
    14521 gtaattaaaa aacatagtgt ttaagtaaac atataagatt gttagttttt taaaagagaa
    14581 ttttttaata atattatatt tatgaagtat ttttaaactt aatttgataa aatatagcta
    14641 tgttttatat actgtagttt tgaacataga aagtttaata aattatagta tatatgttaa
    14701 tttttaataa ggtaagaaag tagaaagaag gatattttat ggatataata aaaaaattaa
    14761 gtcatgggtg tacattagat tgtcatgact gttgtaaatt caatgtttat actaaaggaa
    14821 ataatgtagt aaaaattgaa ggagataaaa atcatcctta tacaaaaggt tttatatgca
    14881 aaaaagggat ggcccattta gatagattaa atcataaaga tagaataaag actcctatgc
    14941 ttaaagttga tggagtatgg aaagagattt cttttgataa agctatagaa ataatggcag
    15001 aaaagcttac atactataaa gaaaagtata catcaaagtc tgtcatgcat tatgaccaat
    15061 atggaagtgg gtctgtgcta aaatacatag gagatatatt ttttaatttt tatggaggtg
    15121 ttagcagaca taagggtggt ccctgttgga gtgcagggat gcatgctcaa aaatatgatt
    15181 ttggagtagc taagagtcat gctatagaag atatgttaaa tagtaaaagt atatttgttt
    15241 ggggaaaaaa tccagcatat actacaattc atactatgca aataattaaa aaagctaaag
    15301 aaaaagggat aaagatagta gtgattgacc ccatatatac aaaaacagct caaatagcag
    15361 ataagtatgt acaagtaaat cctggaacag atggagcttt agctatagct atggcaaaaa
    15421 ttatagtgga agataaatta tatgatgaag aatatataaa ctcgtatgtt attggttttg
    15481 aagaatataa aaaatattta tcttcattgg aattaagttt tttaattgat gaatgtggtg
    15541 ttaaagagaa tgatataaga gagttagtgg atttatatac taacaaatat tcaagtataa
    15601 atgttggata tgggcttcaa aaatataaaa atggtggaaa cacaataaga gcaatagatg
    15661 ctttaggtgc tataactggt caaataggat ttagtggtgg aggggtaaac tatgctaata
    15721 aagtttatcc gagtgttata aattctgacc cttacaatag ccaatcatat ggtgaagata
    15781 gggagtttta tgtaagtaat atcagtaaat ttatagaaga atctttaaaa aatacatcaa
    15841 ataaagtaaa ttatgcatca gatgaacttg atatggcatt acataaagta aattacatat
    15901 cagatgaact tgatacaaca tcaaataaag taaattatgt atcagatgaa cttgatatgg
    15961 cattacataa agtaaattat gtgtcagatg aacttgatac aacatcaaat aaagtaaatt
    16021 atgtatcaga tgaacttgat atggcattac ataaagtaaa tggtgtatca gatgaacttg
    16081 atatggcatt acataaagta aattgtgtat cagatgaact tgatatgaca tcaaataaag
    16141 taaattatgt atcagatgaa cttgatatga catcaaataa agtaaattat gtattagatg
    16201 aacttgatat aacatcaaat aaaacagatt atatatcaaa tgaattgtat aatttatcta
    16261 ataagtcaat caaagataat attcctataa agatggctgt gataactaaa agtaatatgc
    16321 tgaatcaact gccagattta gtagaattgg agagggtgtt ttcaaaaatt gaatttaaag
    16381 tatgttttga tatgtttata actgatacag ttactttatg tgacatgttt ataccgtgta
    16441 caaatacact ggagagtgaa gatataattt atagctcaat gaccaatcca tatataacct
    16501 ataatgaaag agctgtaaag ccagcacata aattgatgga tgaatattac ttctttatgg
    16561 agctagctaa aaagatggga ttaaatgatt atccttttgt agaaaagaga acttatttag
    16621 aaaaagtgat tgaaccactt aagcgttttg acaaaaatct ggatatagaa aaacttaaaa
    16681 acaattactt tactatacat aaccctgttg cttgggaaga taagaagttt gagactccat
    16741 ctggaaaata cgagctttat tcagaaagta taaaaaactt gggaataagt ccaacacctg
    16801 tatatataag caataaatat aaagaaatag aagataaaaa tatttctttt agattattaa
    16861 ctaatcatca tgcagatact ttatttagtc agcattttat ggacaaaaaa tctatagctc
    16921 aagcatatat aaatcagaga atggctaaaa aagtaggtat tgaggagaaa gatattgtga
    16981 tattgaggtc aaaaaaagca aaaataaatg tacaaataaa tatagatgat ggagtaggta
    17041 attatatagt aaaaatgtat gttggttggt ggaagaaaca tggaaatcct aatagtttaa
    17101 cagacactgg tatatcagat tttgggggtc aggtaacata taatgaaagt atggtagaaa
    17161 taatacgaca aaactagtta aatttcattg aaggaataaa aatataatta tagaattgat
    17221 taaaagttac tatttttaca aaactattga aggagggatt tttgatggta aattattcct
    17281 tagaacataa gaatctatac atagaattta tgtgctcaga actagaccac catgtagcca
    17341 atgaaataag ggaagaaata gataacttat taagtgtaaa tcaagtaaaa aatgttgtat
    17401 ttaattttga aaatattaat tttatggatt cttcaggtat aggcgtcatc ataggtagat
    17461 ataaaaagat ttctaatgaa gggggacgag tttcagtaat taatataagt tcacgagtta
    17521 agaagatttt tgatttatct gggttaaata aaattattgg catttatgat acgtatgaag
    17581 aagctctaag ttctttgtag ggaggagtat gtgatgaata atattatgga agttaaattt
    17641 tcggcaatat ctgaaaatga aagtttagca agagttatag tagcatcctt tgcagctaag
    17701 ttagacccaa cagtagatga gttagtagat ataaaaactg ctgtctctga ggctgttacg
    17761 aatgctataa tacatggata tgaagaagac agttctaagt ttgttttctt aagatgtgag
    17821 atagaaggaa atactataaa gattatagtt gaagatgaag ggtatggaat agaaaatgtg
    17881 gagaaggcaa tggaaccact ttatacatca aaaccagaac ttgatagatc aggaatggga
    17941 ttcacagtaa tgaaaagctt tatggacgat gtagaggtaa gttctgtaaa agataatggg
    18001 actagaattg aaatgactaa aaaaataaat gtgcctaaat aaagtccaaa agtgaggttt
    18061 tattatggaa gtaactgttg ccagagaaga aaaaaaacct cttcttagtc atgaagagac
    18121 tctagaactt attgaaaaag ttcaaaatgg agatgaagag gcaaaagaaa tattaatatc
    18181 aagcaattta ggtctagtta ggagcgttgt atctagattt ttaaatatag gatatgatag
    18241 agaagattta tttcagttag gttctatagg cttaataaaa tcaatatata aatttgaccc
    18301 aaaatttaat gtaaaattct ctacttatgc agtaccaatg attttaggtg aaataaagag
    18361 atacttaaga gatgatggta tgataaaagt atcaaggtcg ttaaagcaaa tagctgtaaa
    18421 ggcaaagatg gaaagtgaag ctttaactaa aaaattaggt agagagccga gtatagaaga
    18481 attagctaaa gcaatagatg tagaaaaaga agatttagta atggctatgg aagctaattt
    18541 caatgttgag tatttgcaag gagttattca tgaagaggaa ggttctccaa tatgccttat
    18601 tgataaaata agcatgaaag gagaaagtga agaagaaaaa gtagtggata acatattgtt
    18661 aaaagacata cttggaagac tggataagag agagcgtcaa ataatagttc tcagatactt
    18721 tgaagacatg actcaaagtg aaataggaga gatgctcaat atatcacaag ttcaagtatc
    18781 taggatagag aagaaagtat tgtctaagtt aaaagaatat atatcgtgat aatacttatg
    18841 atatgtagaa taacaaaata taataaatat attactaaaa taaaatgtaa taacttttta
    18901 tgttaagttt ttaaattatt aaaagatatt aaaataataa aaagcattaa aaaagtaaaa
    18961 atataaaaac aaggtgtctt tatggaaaaa tagatttttt ctttattagg catctttttt
    19021 attttttgac caaactttag atagtcaaaa taaataatag gtttattttt ttaaaattaa
    19081 caaataatac tttagagagg tgtttagtat ggataaaaat tataaaaaat atgtagacca
    19141 aataagccca aaacctacat atttaaaaaa ctatacactt gcatttattg taggtggaat
    19201 tatttgtatg atagggcaag caataaatga tttgtatatg aaagttggag gtcttgataa
    19261 actaggtgct agttctgcaa catcaataac attaatattt ataggggcat ttttaactgg
    19321 attaggagtt tacgacctaa taggaaaaag agctggagct ggttctataa ttccaataac
    19381 aggttttgct aactcaatag tatctccagc aatggagtat aaaagagaag gctatgtatt
    19441 aggtgtaggt gcaaacttat ttaaaattgc aggaccagtt ttagtttatg gtataggttc
    19501 ttctatttta tgtggaatta tttattatat ttttaagatg ttttagatga tttttattta
    19561 atttaaattt tattaattat gaagaaggta taaaatctga aaatagctac taaagtaact
    19621 aattgaaaaa taattgtgca gatttaatta aaatttttaa ttaatattaa aaatttgaat
    19681 agtaaaatgc aaaattaaaa aggtgtgaaa atatgaaaaa taaaagaatt ggaaaaagaa
    19741 cagtcaagtt agaaaataaa ccaaccataa tatcaactgg aactatagta ggtcctaagg
    19801 aaggtgaagg accactaaag gactattttg atatgattat gactgacgat ttatatggtg
    19861 aaaagacttg ggaattagct gaaagtaaaa tggtagagac tgcatctcaa caagctatcc
    19921 aaaaggcagg taaaaaattg tcagatgtaa attatatgct aggtggcgat ttaataaatc
    19981 aaatagttcc agcatcattt gcagcaagag aactggctat tccattttta ggtatatatg
    20041 gagcttgttc tacaatggca gaaggtcttt gtataggttc tatgcttata gatggtggtt
    20101 ttgctgattt agtactgtca ggtacatcaa gtcactattg tacagcagaa agacaattta
    20161 gattcccact tgaacttgga aatcaaaaac caatgacagc ccagtggaca gttacaggag
    20221 caggaagtgt attattagct cctaatggag acggtccaaa agtaaagtat gttactgttg
    20281 gtaaagtaat agatgagggt attgatgatg gtaataatat gggaccagct atggctccag
    20341 cagcaataga tactatctac tcttactttg aagatactaa tgatgaccca aatagctttg
    20401 atataattgc tactggagat ttaggtactc ttggaaaaca gatagcagaa gactttctaa
    20461 aagaaaaagg tgtagatata tcaaaagttt atactgactg tggtatagag atgtttaacc
    20521 ttaaagaaca agatgtccac tgtggtggaa gtggatgtgg gtgttcagcc acagtgtttg
    20581 caggatatat atatgataag ttgagaaaaa aagaatttaa caaagtaatg cttgtatcaa
    20641 caggagcact actttcaccg acaagtacac tacaaaagca gacaatacca tgtgttgcac
    20701 atgcagtagt aatagtaaat gagtaggaag tgatataata tgttaatgga ctatgtaaga
    20761 gtatttattg taggtggaat tatatgttta atagcccaag taatgatgga ttatttcaaa
    20821 atgcaaactc catatgttat ggtaacgtat gtaacaactg gtgtagtttt aacttttcta
    20881 ggactttatg agccattagt taagtttgca gcagcaggtg caacagttcc tataatagga
    20941 tttggatatt cacttgctac aggagtaata aaatcaattc aaagtgatgg ttttttaggt
    21001 atttttttag gaggtacaac tgctacagct ggtggaatag cagcagctat attctttgga
    21061 tatattatgt cagtagtatt tactccaaaa gcaaaaccat aaatctttat taaaagaata
    21121 ataagttttt gaaataataa atttttataa agcaggtgga tatcttttag attccacctg
    21181 ttttttatat aaagaagcgt ttacataatt gaagttgaca attatttaca acatagtgta
    21241 gtattatatt atcaaaataa aatgaagtga agtaggggat aaagatggta actattaaag
    21301 atattgcaag gaatctaggt atcagttatt caactgtttc taggtgctta aacaataatc
    21361 ctaatgtatc tgaaaaaaca aaaaagaaag tggtagaaga ggcaaataga ctagggttcc
    21421 attttaatgt aaatgcaaga aatttagcaa aaaaagaaac taacaggata ggggtaatct
    21481 tttcaaataa ttttaatcat caagatacta gaaagttttt tagtgatata atggatagtt
    21541 ctataaattc tattgagact aataaatacg attttataat acagcctaat aataacatta
    21601 gtggtgatag taatgtatat aaaatggtaa atggacaaat ggttgacgga ttagtaattg
    21661 tgtctcaatc aataaaaaaa gaagagtatg attttttaaa agacaataat tttccacatg
    21721 tatttatata ttttaaacca tcttttatag gagaagtaga taatttcttt tgggacgata
    21781 acgtgtatgg aggttatata gctaccaagc atttaattga ccatggtcat aaagatataa
    21841 taacagtaac ttcagatgat aagagttcaa aaatgcatga agatagaacc aagggatatt
    21901 tgaatgctat ggaagaagca aatttaaaga cagaagtcat taaatctaaa atggattttg
    21961 aatctcaagt tgaattttta gaaaaataca ttgataaaat aaaaaaagct tcagctatat
    22021 ttgtacaaca agatgtacca gcgatttcta taatacaaga gttaaaaact acttatggta
    22081 taaatgtacc agaagatatt tccataatag ggtataataa tattgaatta atatcatatt
    22141 ttaggtcgca tttatcaaca atagatgacc caagagagca agttataaaa aatggagtag
    22201 atagtttagt aaatataata aataaaaaga gtacagaaca cattccgaga aaattatatc
    22261 caaggttaat aatacgaaat ag
//
LOCUS       DAEPID010000064        22239 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.064, whole genome shotgun sequence.
ACCESSION   DAEPID010000064 DAEPID010000000
VERSION     DAEPID010000064.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 22239)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 22239)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..22239
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.064"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            33..1805
                     /locus_tag="KR257_002755"
     CDS             33..1805
                     /locus_tag="KR257_002755"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888006.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBH0031435.1"
                     /translation="MENGKFQFFKGVRNCFNMIYLHDKRYLFISMFMAIFQGIVPSIS
                     LLVSQNIINNMQTFSKSVKEILVLLIMYLIINIIPSIFQSFYGYYRIKFNKNFEKHIE
                     TMMLEKSLTLSLKDFEDDNTYDMINRAQSQKGFNITILSENLISIIRESVSTLSLIVV
                     LSQFQLWLIIVVIVIPVLKSLYSIKLGKEQYDVSVNRTWKERKAWYIDYLLSKGYAYK
                     EIMVFRIGSKLINHYKKLKEDIISQDMNIAKKNFIATLLCTVLDSIVSAGIIGFIIIQ
                     GILKKILIGDATTYIQAVQSIKDNVESIFSLFSSVIQDLFYTDLLFKFLDYNCKEDSI
                     EHIKIFEKIGDINKIELINISYKYNHSSEYSLKNINLTLNKNDPIAILGKNGSGKTTL
                     LKILLGFYDDYEGDILINGKNLKDIEKDEYIRKVSCMFQDYIKYEATLKENVAMGDVY
                     KSNLEEKVKSKLKETKLKPSIYEEDGLETILGTWFGKKQLSMGEWQKVAISRTLMKDA
                     DMYIFDEPDSSLDSEAGNELLSLYKKTFENKIGIFITHHIQHAKKITNNIVVLENGKL
                     LESGRHDELMDKKGVYFNLFCNCK"
     gene            1827..3248
                     /gene="ccpM"
                     /locus_tag="KR257_002756"
     CDS             1827..3248
                     /gene="ccpM"
                     /locus_tag="KR257_002756"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729214.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Cys-rich peptide radical SAM maturase CcpM"
                     /protein_id="HBH0031436.1"
                     /translation="MNQKPFIHTFKAGKSYFIYDVNTDKILKVNAAVYNYLNKIEHNL
                     EKESDWNIEIEDEINTLINYGFLKNKRVSKTMHPETKYIKYHIENNLSSIILQVTQNC
                     NLRCDYCIYSGSYSNRVHTNKRMNIDVAKRSIDYLIKNSSQLNEVSVGFYGGEPLLEF
                     DLIKQIVEYVKVVGEGKEIYFNLTTNATLFNEEIIEFFVKNNITTMISLDGGKEIHDK
                     SRKFANTGEGSHDVVLKNVRYIKNKYPEYYKKNITFNTVINSENDYISIDDFISKNET
                     LKDSNFLASTLNNNYSDKEIVSSDEYILGKSYDRFLTLLNKLKFIKDESMSPLSRIER
                     ALLDDFRYEKNIEGRLELPDVWHHGGPCIPGAFRIFVTTDGEFFPCERVSESSKMGMI
                     GNLDSGVDIEKAEKLLNIGKLYEEQCSDCWAYSYCDICIAKIDDTKCNENEIKPHDCD
                     RIRHSTENNMKDYCVLKSLGYQY"
     gene            3277..4347
                     /locus_tag="KR257_002757"
     CDS             3277..4347
                     /locus_tag="KR257_002757"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888008.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TIGR04066 family peptide maturation system
                     protein"
                     /protein_id="HBH0031437.1"
                     /translation="MEKVLIYPFNYNFFTILNHCNKISDIEINSLVSPSGWGLCNKEY
                     NVNNIITKVTNDFQSELKKNSLVWFVDSKENLDLEKFIIPKLKVALKEGKKILYTRDD
                     LNKISRYISHYEFKKINEWNLEKYEIRDIEGISQINTPIIFICGLYGGLDTFDVNIRI
                     GEELRKRGFSILQFGPKKESYLFKMIPIPEFMFDDSISSKTKIINFNHFIKDKEVEAK
                     PDLIIIEVPGELFPFSRKMVGNFGIRAFEISNAVINDCGILCIPSSIYDREYCEELKY
                     FIKGRHGINIDYFSIEKKVIDTYETEVKQKFSYMSLDENFFVEDIEDYEKTFFIHDNK
                     QLLELVDNIVNQLKEYAKVISI"
     gene            4363..4614
                     /locus_tag="KR257_002758"
     CDS             4363..4614
                     /locus_tag="KR257_002758"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888009.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptide maturation system acyl carrier-related
                     protein"
                     /protein_id="HBH0031438.1"
                     /translation="MNYTEKELLLENIFFDVTGINFNKNNNLKKELFFSPSLHIQPRE
                     LLLVFCEVIENFNIKIPEEKLLNRQFTSFDNVLKIINMV"
     gene            4665..4868
                     /locus_tag="KR257_002759"
     CDS             4665..4868
                     /locus_tag="KR257_002759"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888010.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0031439.1"
                     /translation="MSFGKRIEMNNIGVETRGVCTIMCPYTCKMMASSSCNCKNNDYN
                     ARGGSYNTYYNKLIHGQRTPDGM"
     gene            5354..5647
                     /locus_tag="KR257_002760"
     CDS             5354..5647
                     /locus_tag="KR257_002760"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888011.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0031440.1"
                     /translation="MISMIMMLIGVLFIVFGIILTAVEIKGKMPGFYGVGQNAVRKNA
                     IGIIAAGIALIFFRNGLDSIDSILTYGVFLVIELVVIGLYFLIRIKYDKDGNL"
     gene            complement(5779..7128)
                     /locus_tag="KR257_002761"
     CDS             complement(5779..7128)
                     /locus_tag="KR257_002761"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009901680.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amino acid permease"
                     /protein_id="HBH0031441.1"
                     /translation="MEKAKKLGLFSMILLGINSIIGSGIFLLPGKVYNLAGQNSMFIY
                     IFATLLVLSILLCFAEVGSMFDKKGGAYLYSKKAFGDFIGFEVGTMSWVIRIISWSTL
                     AVGFATALGSFWPESATEYKGYIAAILVTLLSINSLFGIKSTKIMNNVITIAKLVPLI
                     VFIIVGIFFIKFVNIVPSGNVVNSSMGPAIILVFYAFTGFESFIVASGEMENPKKNLP
                     VALITTIFICAIIYILIQIVCMGILGDRLFENSIPIADASSVFVGNYGKVFISVATLI
                     SIFGINIGSSIVTPKCGSSLAEEGSLPAFIGKTNKYGAPYVAIIISLICCIPLVLTGS
                     FEQLAVMSVIARFAQYIPTCLSVIVLRKRTDVKASFKIPFGPVIPIVAILGSLWLLQQ
                     AWAEDISKPITQNRVLIGLGAMLLIAPLYIFMKKNKEIEHKNKSEDSKLYISREKIQ"
     gene            complement(7165..8385)
                     /locus_tag="KR257_002762"
     CDS             complement(7165..8385)
                     /locus_tag="KR257_002762"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888013.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amidohydrolase"
                     /protein_id="HBH0031442.1"
                     /translation="MQQALKLKYQTKELGKDFVIESCNSIKPWLINIRRELHKIPELA
                     LEENLTKQKVISYLKEIGIDYMEFTKHNGIMAYILKESADKTICIRADMDALPIEEEN
                     NIPYKSIHSGKMHACGHDAHTTMLLGACKVLHSIKDKLNVNVKFLFQPAEEGFGGAKF
                     LVEDGCLENPKADYIFGLHVMPHIETGLIETKYDTLNASVDTIKISIKGKRAHGAYPE
                     NGIDAIVTASQIVTSLQTIISRNLEPNNAVVLTIGKIYGGDAHNVICEDVKLEGTLRT
                     LNSKTRNFMIDKIAKIVGDTASAFGCVGTLHVSDENYPAVINEKELVDTVISNTKELL
                     GEEKFILRPNPSLGGEDFSFYTEHCKGAFFHLGCKNEEKGLISPLHTSSFNIDEDCLP
                     IGVMMHVMNTLYFN"
     gene            complement(8754..10766)
                     /locus_tag="KR257_002763"
     CDS             complement(8754..10766)
                     /locus_tag="KR257_002763"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888014.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sigma 54-interacting transcriptional regulator"
                     /protein_id="HBH0031443.1"
                     /translation="MKKSVALVNDSRKDLIDFLENNLKLVFGDSININRYFINEINDN
                     DIINDDVILVMSVERLDKIINNILDKKKVIVVRRTFREDKIYNLLSLPQGTNVLIVND
                     SDETTLETISLFYKIGVTNIRPIPYMNDNNYKNIKIAITPGVPEKVPSFISDIFDLGH
                     RYIDISTFIEIINLLQIDSKEIQSNLVKYSEEIISLDTGIKDKYKELFLKIEELDTIL
                     NLSKDGILFTSKDGEINTYNSKVKDILDINEDIYGKYIEDIFVDSLKVLLSEKEILDK
                     VVVFNKKYINVNKKNIYNRDEKMGTYYSLQEITYIKKLEQNLTKKLREKGQIAKYTFK
                     DIKTNSPKMFECIDLAKKVSKSDLSILIRGESGTGKELIAQSIHNNSNRKNQPFIAVN
                     CAAVPENLLESQLFGYDKGTFTGGLKDGKQGLFELANNGTIFLDEIGDMPLELQTKLL
                     RVLQEKQIMPVGSHNVINIDVRIISATNKNLEQMIDNSQFREDLYYRLNTIPINIPPL
                     RERKEDILIIMEDLINKKLVITPEAKKLIQNYMWKGNIRELQNVTSYLNIMCEDIVLE
                     KDLPPNLRSSDNKNTSLKLKYSKNDILNILEILILNKESDVGIGRGLILKALLDKNLQ
                     ITEGKIKKIFEYLKKEELIICSSGRYGSKITQKGEDFYNKLKYKGL"
     gene            11237..11887
                     /locus_tag="KR257_002764"
     CDS             11237..11887
                     /locus_tag="KR257_002764"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434477.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cyclic nucleotide-binding domain-containing
                     protein"
                     /protein_id="HBH0031444.1"
                     /translation="MKAEKTSIYPIIKNNLNKISIVEYKKGQRFVASDKDLQEVFFII
                     EGVALVECTTRGGNKFLVDIVPENEFIGKISYIYEHNLKCDIFAKTNIKLFRFEKNVF
                     EEFYLKPDFIALFHRKCTRRIYELYKTRMVRELFSCTEVIAYCISNKQENNVCNIKAI
                     RNFSEIYSISRKSRYHSLLKLTEKEIVKKMGNTYEILNYDELHKLAFEVKEFLEDE"
     gene            complement(12027..13403)
                     /locus_tag="KR257_002765"
     CDS             complement(12027..13403)
                     /locus_tag="KR257_002765"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425390.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MATE family efflux transporter"
                     /protein_id="HBH0031445.1"
                     /translation="MQELFSLKDENKRFYKILLSLCIPIIIQNLISTSVNVIDTIMIS
                     SLGETSVASVGVANQFFFLFNMSLSGITGGAGVFISQFYGKKDVSNIRKVTGLTCVLA
                     IVLSFVFVIPALLTPKPIIHIFSYDSEVVKLCIDYFSIAVFSYPLIAVSTVFSTGSRG
                     VRNPKLGMICSAFALVTNVILNYGFIFGNFGLPALGVKGAALATVIARICELILMITY
                     VYLYKKDYILKFGLKNLKAIDKIFIKSFSSKSFPIFVNDSVWAIGTVLYSVAYARAGT
                     SAIAASQIATSTGNFFIMTAVCIASGASIMLGNELGADHIKRAIEYAKKFSILVFSAG
                     LILGIILILNIPLLLKMFSVSDSLASDITKIFFIMGILMALKSFNTLVIIGILRSGGD
                     TKYALFLELGCMWLASIPLTFIAAFKGAPIFVLVLLTYSEEVVKFIFGVPRALSKKWA
                     INIVKEID"
     gene            complement(13419..15332)
                     /locus_tag="KR257_002766"
     CDS             complement(13419..15332)
                     /locus_tag="KR257_002766"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420835.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC-F family ATP-binding cassette
                     domain-containing protein"
                     /protein_id="HBH0031446.1"
                     /translation="MIVLSCNNLNKSFGIDSILENISFTVNEGDKIGIIGVNGTGKTT
                     LFKIISGIYGYDSGDIYTSKDCEIGYLEQNTNFYSDNTILEEVLEVFKNLIEMESYLR
                     ELEVKISEESTKTNSPIIEKIMDEYSHKLELFSDLNGYGYKSEAKGVLKGLGFSDNDM
                     DKPISILSGGEKTRVLLGKLLLKKPTLLLLDEPTNHLDSEAIEWLEVFLKQYKGTVML
                     ISHDRYFLDQSVNRIFEVHNKKLKVYNGNYSKFVELSKIEKELELKKFEDQQKEIKKQ
                     EESIERLKAYGREKHLKRARSKEKALDKVDVLDKPEAYRKKARIQFTPSVQSGNDVLQ
                     IRDVSMGYGERILFKDLDLDIYRGEKVALIGANGVGKSTLFKIITNELQPLSGNIKFG
                     TNVHVSYFHQEQKTLNLDNTIIDEIWENNTHLTQTTLRNMLGAFLFVDEEVFKKISTL
                     SGGERARVAILKLILSNANLLLLDEPTNHLDIDSKEVLEEALTNYDGTIFTISHDRYF
                     LNTVVDKILVLDENGITEYLGNYDYYIDKKRQIQEMSIIEEKEEKTRTQIKDEKRKER
                     EQREIEKKNRIKRQNIEKEIEKLEIEIEKLDILLCQEEVYSNPDKAKEVSQEKINLEN
                     NLASLYDEWEEFM"
     gene            15468..16100
                     /locus_tag="KR257_002767"
     CDS             15468..16100
                     /locus_tag="KR257_002767"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420839.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="redox-sensing transcriptional repressor Rex"
                     /protein_id="HBH0031447.1"
                     /translation="MLGNKNISMAVIRRLPKYHRYLGDLLDRDIQRISSKELSDIIGF
                     TASQIRQDLNNFGGFGQQGYGYNVEALHTEIGKILGLDRPYNAVLVGAGNLGQAIANY
                     AGFRKAGFEIKALFDANPRMIGLKIREFEVLDSDTLEDFIKNNNIDIAVLCIPKNGAQ
                     EVINRVVKAGIKGVWNFAPLDLEVPKGVIVENVNLTESLFTLSYLMKEGK"
     gene            16239..16778
                     /locus_tag="KR257_002768"
     CDS             16239..16778
                     /locus_tag="KR257_002768"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860658.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TraR/DksA C4-type zinc finger protein"
                     /protein_id="HBH0031448.1"
                     /translation="MVFVEELWKKAIEFHGHECPGLAIGFKAALAAKKYLGCKQSGDE
                     EIVCISENDACGIDGIQVVLSCTMGKGNLLLRMTGKSVYHFFNRENGKSIRIYVKSKP
                     FEMDREGYKRYLLESDFEEIFEITDTKLRLPEKARIFKSLKCEVCGEFASEQYIRIEE
                     GKKVCLDCFDKYERFYEEY"
     gene            complement(16954..17124)
                     /locus_tag="KR257_002769"
     CDS             complement(16954..17124)
                     /locus_tag="KR257_002769"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004619190.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="4Fe-4S binding protein"
                     /protein_id="HBH0031449.1"
                     /translation="MAYKITDACISCGACEAECPVSCISAGDDAYVIDAGSCIDCGSC
                     AGACPVDAPQPE"
     gene            17409..18476
                     /locus_tag="KR257_002770"
     CDS             17409..18476
                     /locus_tag="KR257_002770"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729218.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CapA family protein"
                     /protein_id="HBH0031450.1"
                     /translation="MKNKLVYICIMSLLLFVVGCSNNPNKESTIKKDSKNNQSQVKEE
                     KREPVKKDITISFAGDVTMGNYKGSSYYGSFDHEFKRQGEDYNYFLKNVKPVFEKDDL
                     TVVNLEGPLTTASNAKEKKFAFKGKPGYVNILKSGSVEAVSIANNHSEDYFEEGMKDT
                     QFILDENKINYFGLGKDAVVDVKGIKVGLLGYNGLSTEYNEKNLKQMEDDIKSLKKKS
                     DVVVVYFHWGIELDYYPDKKQKDFAHYAIDKGADLVMGSHPHVIQGIEKYKNKYIAYS
                     LGNFCFGGNKNPSDTDSYIYQQTFTFSDNKLTSIKEPNIIPTSITSSNSRNNYQPKIL
                     DGSEKDRVLNKLEKISKDLNK"
     gene            18646..20547
                     /gene="cooS"
                     /locus_tag="KR257_002771"
     CDS             18646..20547
                     /gene="cooS"
                     /locus_tag="KR257_002771"
                     /EC_number="1.2.7.4"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888019.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="anaerobic carbon-monoxide dehydrogenase
                     catalytic subunit"
                     /protein_id="HBH0031451.1"
                     /translation="MACNTCKMCESADKKLESFVASKDVETAFHRTEDQKVKCGFGLQ
                     GVCCRLCSNGPCRVTPKSPRGICGADADTIVARNFLRAVASGAACYLHVVENTAKNLK
                     NVGITKGVVKGEKTLNQLAEMFGIESDEKYDKCIKVADKVINDLYKSRDDKMELVEKI
                     AYAPRVKKWKELGIMPGGAKSEVFDAIVKSSTNLNSDPVDMLVNCLNLGISTGLYGLT
                     LTNLLNDVMLGEPVIRMAPVGFNVIDPDYINIMITGHQHSTFANFQDRLKDEDVIKLA
                     QSVGAKGFKLVGCTCVGQDLQLRGEHYQEVFAGHAGNNFTSEAVLSTGAIDIVLSEFN
                     CTIPGLEPIADKYKVKMVCLDDVAKKANAECIGLDRSKLDELSNTLIEKALESYKERR
                     GSIEIDIPKDHGFEQSLTGVSEKNLKAFLGDSWKPLINLIAEGKIKGVAAVVGCSNMT
                     AGGHDVNTVELTKELIKKDIIVLSAGCSTGGLENVGLMSPGAEELAGENLKEVCKTLG
                     IPPVLNFGPCLAIGRLEIVATELAAELGIDLPQLPLVLSAPQWLEEQALADGAFGLAL
                     GLPLHLALPPFITGGKLVTEVLTEKLKDLTGGHVIVNPDPKSSANQLEEIIIDRRKNL
                     GLKDVECNA"
     gene            20540..21013
                     /locus_tag="KR257_002772"
     CDS             20540..21013
                     /locus_tag="KR257_002772"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860659.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="4Fe-4S dicluster domain-containing protein"
                     /protein_id="HBH0031452.1"
                     /translation="MHRIFINKDLCTGCKSCVLACMLKHNKDYDMYTLDLENIDNDSR
                     GHIELDSRHNNPVPILCRHCDEPECVLACMSGAMHKDSESGIVSYDEEKCGSCYMCVM
                     SCPYGLLKPDDRSKQNILKCDLCKDEEYPRCVANCPSGAIELQKEENDELCSVRG"
     gene            20988..22214
                     /locus_tag="KR257_002773"
     CDS             20988..22214
                     /locus_tag="KR257_002773"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895268.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NAD(P)/FAD-dependent oxidoreductase"
                     /protein_id="HBH0031453.1"
                     /translation="MNYVVLGASAAGINAVKTLRELDKDSNIVVISKDENVYSRCMLH
                     HVISEHRTLKQINFVDEDFMEQNNVKWIAGKTVKGIDINKKVVQTEDITVNYDKLLIA
                     TGASSAIPPIKNLRDGNFVYSVRNIDDIYKIKEKAQNSKNVVIIGAGLVGIDALVGLF
                     KYEQLNISVAFMEKYILDRQLDEYTASVYENKFKEKGVKFYPSASIQEIVLDNSKNVT
                     GVAFSNGEVLDADMVIVATGVKPNADFLDGTGIEYDRGIIIDDMCQTTQKDIYAAGDV
                     VGKNAIWPLAVKQGIVAAYNMVGKDKKIEDEFAFKNSMNFMDIPTISIGMNTPVDDSY
                     KVLTRHGINDYKKFVFKDNVIYGAVIQGDISYVGVLTYLIKNKVEIYDLENRIFDICY
                     ADFFNIKENGEFCYSV"
BASE COUNT         8345 a         2656 c         3343 g         7895 t
ORIGIN      
        1 tatttcaatt ttattaagta tggaggtgta ttgtggaaaa tggtaaattt caatttttta
       61 aaggtgtaag aaattgtttt aatatgattt atctacatga taaaagatat ttatttatct
      121 ctatgtttat ggcaattttt caggggattg ttccatctat ttctttgtta gtaagtcaaa
      181 atatcattaa taatatgcaa acattttcga aaagtgtaaa agaaatatta gttttgttaa
      241 ttatgtattt aatcataaat ataattcctt caatttttca aagtttttat ggatattata
      301 gaataaagtt taataaaaat tttgaaaaac atattgaaac aatgatgtta gagaaatctt
      361 taactttgag tttaaaagat tttgaggatg ataatactta tgacatgata aatagagctc
      421 aatctcaaaa aggatttaat attactatac tatctgaaaa ccttatttca ataataagag
      481 aatcagtatc tacactttct cttattgttg tattatcaca atttcaactt tggctaataa
      541 tagttgttat tgttattcct gtattgaaat cattatattc cattaaatta ggaaaggaac
      601 aatatgatgt tagtgtaaac agaacttgga aagaaagaaa ggcctggtac atagattatt
      661 tgttgtcaaa aggttatgct tacaaagaga ttatggtatt tagaattggt tctaaactta
      721 ttaatcatta taaaaaatta aaagaggata ttatatctca agatatgaat atagctaaaa
      781 agaattttat tgctacgcta ttatgtacag ttttagattc aattgtatct gcaggaatta
      841 taggatttat aataattcaa ggtattttaa agaagatttt aataggagat gcgactacat
      901 atatacaagc agttcaatct ataaaggata atgttgaatc aatattttcg ttatttagtt
      961 cagtaataca agatcttttt tatacagatt tactgtttaa atttctagat tataactgta
     1021 aagaagactc aattgaacat ataaaaatat ttgaaaaaat aggggatata aataaaatag
     1081 agttaataaa tatttcatat aaatacaatc attcatcaga gtattcttta aaaaatatta
     1141 atttaacttt aaataaaaat gatcccattg ctatactagg aaaaaatggt tcaggtaaaa
     1201 cgacactttt aaaaatatta ttaggttttt atgatgatta tgaaggtgac atcttgataa
     1261 atggaaaaaa tttaaaggat attgaaaaag atgaatacat tagaaaagta agttgtatgt
     1321 ttcaagatta tattaaatat gaggctacat taaaagaaaa tgtcgccatg ggagatgtat
     1381 ataagagtaa cttggaagaa aaagttaaaa gtaaacttaa agaaactaaa ttgaaaccaa
     1441 gtatttatga ggaagatgga ttagaaacta ttttaggaac ctggtttggt aagaagcaac
     1501 tttctatggg tgaatggcaa aaagtagcaa tatctagaac tcttatgaaa gatgctgata
     1561 tgtacatttt tgatgaacca gattcatctt tagattctga agcgggaaat gaactccttt
     1621 ctttatataa aaaaacattt gaaaataaga ttggaatatt tataacgcac catatccaac
     1681 atgcaaaaaa gataactaac aatattgtag ttcttgaaaa tggaaagttg ttagaaagtg
     1741 gaagacatga tgaacttatg gacaaaaagg gtgtttattt taatttattt tgtaactgca
     1801 aataaatatt aaagggaggt taattaatga atcaaaaacc atttatacac acatttaaag
     1861 ctggaaaatc atattttatt tatgatgtta atacggataa gattttaaag gtaaatgctg
     1921 ctgtttataa ttatctaaat aaaattgagc ataatttaga aaaagaaagt gactggaaca
     1981 tagaaataga agacgaaatt aataccttga ttaattatgg atttctaaaa aataaaaggg
     2041 taagtaaaac aatgcaccct gaaactaagt atataaaata tcatatagaa aataatctat
     2101 cctctattat tttacaagta acccaaaatt gtaatttacg ttgtgactat tgcatttatt
     2161 ctggttcata cagcaacaga gttcatacaa ataaaagaat gaatatagat gtagcaaaaa
     2221 gaagtattga ctatttgatt aagaattcta gtcaattaaa tgaagttagt gttggctttt
     2281 atggaggaga acccttactt gagtttgatt tgattaagca gatagtagaa tatgtaaaag
     2341 tagttggaga aggaaaggaa atatacttta atctaactac aaatgcaact ttatttaatg
     2401 aggaaataat agaattcttt gtaaaaaata atataacaac tatgattagt ttagatggag
     2461 gaaaagaaat tcatgataaa agtagaaaat ttgcaaatac aggagaagga tctcatgatg
     2521 ttgtattaaa aaatgtacgt tacataaaaa ataaatatcc agaatattat aaaaagaata
     2581 ttacatttaa tacagtgata aattcagaaa atgattacat ttctatagat gattttatat
     2641 ctaaaaatga gactttaaaa gattcaaact ttttagcttc cactcttaat aataactatt
     2701 ctgataaaga aatagtttca tcagatgaat atatattagg taagagttat gatagattct
     2761 tgactttact caacaaatta aaatttataa aagatgagag tatgtcacct ttatcaagaa
     2821 tagaaagagc cttattagat gattttagat atgagaaaaa tattgaaggt agattagagt
     2881 taccagatgt gtggcatcat ggtggaccat gtataccagg agcttttaga atatttgtaa
     2941 ctacagatgg agaatttttt ccatgtgaga gagtaagtga aagttctaaa atgggtatga
     3001 ttggaaattt agatagtgga gtagatatag aaaaggctga aaaactttta aatataggaa
     3061 aattatatga agagcaatgt tctgattgtt gggcctatag ttattgtgat atatgtatag
     3121 ctaagattga tgatactaaa tgtaatgaaa atgaaataaa accacatgat tgtgacagaa
     3181 ttagacattc tacagaaaat aatatgaaag attactgcgt tttgaaatct ctaggatatc
     3241 aatattaaat tttctaatga aaggaaagat gggattatgg aaaaagtact tatatatcca
     3301 tttaattata atttttttac tattttaaat cattgcaata aaatttcaga tatagaaatt
     3361 aattcactgg ttagtccttc tggctggggg ttatgcaata aggagtataa tgttaataat
     3421 attattacta aagttacaaa tgattttcaa agtgaactta aaaagaattc tttggtatgg
     3481 tttgttgatt caaaagaaaa tctagactta gaaaaattta taattcctaa attaaaagta
     3541 gctctaaaag aaggtaaaaa gatattatat acacgtgatg atcttaataa aatatctagg
     3601 tatatatctc attatgaatt caaaaagatt aatgaatgga atttagaaaa atatgaaata
     3661 agagatatag agggtatatc acagataaac acaccaataa tatttatttg tggtctttat
     3721 ggagggttag atacttttga tgtaaatata aggataggag aagaactaag aaaaaggggg
     3781 ttttcaatat tacaatttgg ccctaaaaaa gagagctatt tatttaaaat gattcctata
     3841 ccagagttta tgtttgatga ttcgataagt agtaagacaa agattattaa ttttaaccat
     3901 tttataaaag ataaagaggt agaggcaaag ccagatttaa taattataga agttccagga
     3961 gaattattcc ctttctctag aaaaatggtt ggtaattttg gaattagagc ttttgaaatt
     4021 tctaatgcag taataaatga ttgtggtata ttatgtattc catcaagtat atatgataga
     4081 gaatattgtg aagaacttaa atattttatt aaaggaagac atggtataaa tatagactat
     4141 tttagtatag agaaaaaagt tatagataca tatgagacag aggtgaagca aaaattttca
     4201 tatatgtcat tagatgaaaa cttttttgtt gaagatatag aagattatga aaaaacattt
     4261 tttatacatg ataataaaca attactagaa ttagtggaca atatagtgaa tcaattaaaa
     4321 gagtatgcta aagtaatatc tatttagaat tggaggttaa ttatgaatta cactgaaaag
     4381 gaattactac tagagaatat attttttgat gtgactggaa ttaattttaa taaaaataac
     4441 aatttaaaaa aagaattatt tttttcaccg tctttacata tacagccaag agaattactt
     4501 ttagtatttt gcgaggtaat agaaaacttt aatataaaaa ttccagagga aaaacttttg
     4561 aataggcaat ttacgagttt tgataatgtt ctaaaaataa tcaatatggt ataggttaat
     4621 aaaggtataa agtaagtgat cttatagaaa aggggaggat atgaatgagt tttggaaaaa
     4681 gaatagaaat gaataatata ggtgttgaga caagaggtgt ttgtactatt atgtgtcctt
     4741 atacttgtaa gatgatggca tcttcatctt gtaactgcaa gaataatgat tataatgcaa
     4801 gaggaggatc atataataca tattataata aattgataca tggccaaaga actcctgatg
     4861 gaatgtaaat atttcagtaa taagtatact attaaattga tttagcatat ttgattaaat
     4921 ttatctttct tactttattt ccttttatta taaaaatatg cagttgatta taattaagag
     4981 tgtgatttta taataactgc ataaatagta tctgttatat aaatcacctc ttcaattatt
     5041 atagtggtaa atatagtgat taggggtgat ttttacaatt taaaagtata aattaattaa
     5101 aagttattat aataaattat acttatttaa atagtaagaa ttaaaagtaa agtttttaaa
     5161 tatatttgta aaaatgtata tatatattaa taatattgat tagaattaat atattatttc
     5221 aatatttaaa cattatttat tggtactaat ttccaaaata gttaattgga tatacaatat
     5281 tattataaaa aataaatatt atttatttta gattttagaa attgaaattt ccttaagtga
     5341 aggaggtaat tagatgatta gtatgattat gatgcttatt ggagtattat ttatagtgtt
     5401 tgggataatt ttaactgctg tcgaaataaa aggaaaaatg ccaggttttt atggagttgg
     5461 gcaaaatgca gtaagaaaaa atgctatagg gattatagca gcaggtatag cattaatttt
     5521 ttttagaaat gggttagata gtattgattc aattcttacc tatggagtat ttttagtgat
     5581 agagttagta gtaataggat tatattttct tataagaata aaatatgata aagatgggaa
     5641 tctttaaagt ataaattaat aatattttga ttttgatata tgtttatata aaaaaattgt
     5701 agataaattt tataaaatag ttttatctac aattttttta tatttattat attttatgag
     5761 aagtaatagt ataaaatatt attgaatttt ttctctcgaa atatataatt tagaatcttc
     5821 tgatttattt ttatgctcga tttccttatt ttttttcata aatatatata gaggagctat
     5881 taacaacatt gcccctaatc ctattaaaac tctattttga gttataggtt ttgaaatatc
     5941 ttctgcccaa gcttgttgta acaaccataa gctacctaaa atagctacta ttggtataac
     6001 agggccaaat ggaatcttaa aagaggcctt aacatctgtt ctttttctta aaactattac
     6061 tgataaacaa gttggtatgt actgagcaaa tcttgcaatt acgctcatta ctgcaagttg
     6121 ttcaaaactt ccagttagca caagtggtat acaacaaatt aaagatatta ttattgctac
     6181 atatggagca ccatatttat ttgtttttcc tataaatgca ggaagagaac cttcttctgc
     6241 tagagaagaa ccacatttag gagttactat tgatgaacct atatttatac caaatataga
     6301 tattaatgtt gctacagata tgaaaacttt accataattg cctacaaata cacttgaagc
     6361 atctgcaatt ggaatactgt tttcaaatag tctatctcca agtataccca tacagacaat
     6421 ttgaattaat atataaatta ttgcacatat aaatattgtg gttattaatg cgactggaag
     6481 atttttttta ggattttcca tttctccact tgccacaata aatgattcaa agccggtaaa
     6541 tgcgtaaaat actaatataa tggctggacc catactagag ttaactacat ttcctgaagg
     6601 aacaatattt acaaatttta taaaaaatat tccaactatt ataaaaacta ttaatggtac
     6661 taatttagct atagttatta cattattcat tatctttgtg cttttaattc caaataagct
     6721 atttattgaa agtagtgtta cgagtattgc agctatataa cctttgtatt cagtggcaga
     6781 ttctggccaa aatgaaccta aagctgttgc aaatcctact gctagagtag accatgatat
     6841 aattctaata acccaagaca ttgtaccaac ttcaaatcct ataaaatctc caaaagcttt
     6901 tttggagtat agatatgctc ctcctttctt atcaaacatg cttccaactt ctgcaaaaca
     6961 taaaagtatt gatagaacta agagtgtagc aaaaatgtat ataaacatac tgttttgacc
     7021 tgctagatta taaactttac ctggtagtaa gaatatacct gaacctatta tgctattaat
     7081 ccctaataat atcatactaa atagacctaa tttcttagct ttttccatat taatttatct
     7141 cctattcttt tattaattac tgtactaatt aaaatacaaa gtattcatta catgcatcat
     7201 aacacctatt ggtaaacaat cttcatctat attaaagcta gaggtatgaa gaggtgaaat
     7261 taagcccttt tcctcatttt tacatcctaa atggaagaat gctcctttac aatgttctgt
     7321 gtaaaaagaa aagtcttcac cacctaaaga cgggtttggt ctcaatataa atttttcctc
     7381 tccaagtaat tctttagtat ttgatataac tgtatctact aattcttttt catttataac
     7441 agcaggatag ttttcatcac ttacatgtaa agtcccaaca caaccaaatg cagatgcagt
     7501 atctccaaca attttagcta ttttatcaat cataaagttt cttgttttgc tatttaaggt
     7561 tcttaaagtg ccttctaatt ttacatcttc acatattaca ttgtgtgcat caccaccata
     7621 tattttacct atagtcaaaa caacagcatt atttggttct aagtttctac ttattatagt
     7681 ttgtaatgat gtaacaattt gtgaagctgt aactattgca tcaataccgt tttcaggata
     7741 tgcaccatga gctcttttac ctttgatact tatttttata gtgtctacac tagcatttaa
     7801 tgtatcatat tttgtttcga taaggcctgt ttctatatgt ggcataacat gaagtccgaa
     7861 tatataatcg gccttggggt tttctaaaca cccatcctca actaaaaatt ttgctcctcc
     7921 aaaaccttct tctgctggtt gaaataagaa ttttacattt acattaagtt tatcttttat
     7981 tgaatgtaaa actttacatg ctccaagtag catggttgta tgtgcatcat ggccacaagc
     8041 atgcattttt ccagaatgta ttgatttata aggtatgttg ttttcttctt caataggaag
     8101 agcatccata tctgctctta tacaaatcgt tttatctgca ctttctttta aaatatatgc
     8161 cataattcca ttgtgttttg taaattccat ataatcaatt ccgatttctt ttaaataaga
     8221 aattaccttc tgtttagtaa gattttcttc aagagctaat tctggaattt tatgtaattc
     8281 tcttcttatg tttataagcc atggttttat agaattacaa ctttctatta caaaatcttt
     8341 tcctaattct ttggtttgat attttaattt caaagcctgt tgcattttta ttcctccaat
     8401 tgctttttat tgttttatta atataataag caattattat gccataattt tcgatggaga
     8461 attttgtttt ttataagaat attgaataaa tataatcatt tatctatatg tatagtataa
     8521 aaaatgattg catagtttca attttcagta aaaaatatta ttttgaagaa aatatatttt
     8581 atatgctagt ttatataaaa aaaataggaa ataaaaaaat tatcctattc ctattaattc
     8641 ctattattta tgtacaaaat aaattataat tttagggtac ttgaaaaata aaaaaaccta
     8701 ttgaaggagt actttaatcc tgaatagatt tctttgtttg ataaattata attttataga
     8761 cctttatatt ttaatttatt gtaaaaatct tctccttttt gagttatttt acttccatat
     8821 cttcctgaac tacaaattat aagttcttct ttttttagat attcaaatat ttttttaatt
     8881 tttccttctg taatttgaag gttcttatcg agtagtgctt ttaaaattaa tcctctacca
     8941 ataccaacat ctgattcctt atttaaaatt agtatctcta atatattcaa tatatcattc
     9001 ttactatatt ttagttttaa tgatgtattt ttgttatctg aagaccttaa gtttggaggt
     9061 aaatctttct ctaatacaat atcttcacac ataatgttta aataggatgt aacattttgg
     9121 agttctctta tattaccttt ccacatatag ttttgtataa gtttttttgc ttctggtgtg
     9181 attactaatt tcttattaat taaatcttcc ataataatta atatgtcttc ttttctttct
     9241 cttagaggag gtatatttat tggaattgta tttaatcgat aatataaatc ctctctaaat
     9301 tggctattat caatcatttg ttctaaattc ttatttgtag cagatatgat tctaacatct
     9361 atattaatta cattgtgaga tccaacaggc attatctgct tttcttgaag aactctaagt
     9421 agttttgttt gtaattctaa aggcatatcg cctatttcat ctaagaatat tgttccatta
     9481 ttagcaagtt caaataatcc ttgttttcca tcttttagac ctccagtaaa agttcccttg
     9541 tcatatccga atagctggct ttctaataaa ttttcaggaa cggctgcaca atttactgct
     9601 ataaagggtt gattttttct atttgagttg ttatgtatag actgagctat gagttcttta
     9661 ccagttccac tttcacctct gataagtatg cttaaatcag atttagaaac cttcttagct
     9721 aaatctatac attcaaacat tttaggacta tttgttttta tatccttaaa tgtatatttt
     9781 gctatttgtc ctttttctct taatttttta gtgagatttt gttctaattt ttttatgtat
     9841 gttatttctt gtaaactata atatgtgccc attttttcat ctctattgta tatgtttttt
     9901 ttatttacat ttatatattt cttattgaat acgacaactt tatctagtat ctctttctca
     9961 ctcaataaaa cttttaaact atctacaaat atatcctcaa tgtattttcc atatatatcc
    10021 tcatttatgt ctaaaatatc ttttacttta ctattatatg tatttatttc accatctttt
    10081 gaagtaaata atataccatc ttttgataaa ttcaagattg tatctaattc ttctattttt
    10141 aaaaataatt ccttatattt atcttttata ccagtatcta aacttattat ttcttctgag
    10201 tatttaacta gattagattg tatttccttt gaatcaattt gtaataaatt tattatttct
    10261 ataaatgtag agatatctat atatctgtga cctaaatcaa atatatctga gataaagcta
    10321 ggtacttttt ctggaactcc tggagttata gctattttta tatttttata gttattatca
    10381 ttcatatatg gaattggtct aatattagtc actccaattt tataaaataa acttatagtt
    10441 tctagagtag tttcatcaga atcatttacg attagaacat ttgtaccctg tggtaaagat
    10501 agtagattat aaattttatc ttccctaaaa gttcttctta ccacaatcac ttttttctta
    10561 tctagtatat tatttataat tttgtctaat ctttctactg acattactaa tatcacatca
    10621 tcatttataa tatcattatc atttatttca tttatgaagt atctattaat atttatagaa
    10681 tctccaaaaa ctaatttcaa attattttct aaaaagtcta ttaaatcttt tctactatca
    10741 tttaccagag ctactgattt tttcatttat ttctccttat ataataaata gtttccaaca
    10801 aaatagttgt ataaagcaat ctaattttga taatttaaat ttatcaaata aaaaagaaag
    10861 tgtctataat gactttctaa aagttgcatt aagacacttt ctttcttata gttaaaaatc
    10921 ttgtcaccaa atccccctaa ttgttgctta aaacttaaac tgtatgtata tttttcattt
    10981 ctattcgatt aaattataat atacacccaa aaaaatttat tttaataaat tctattgata
    11041 atataatttt ataaatatag aattatatta aaataaatta tatatgaaaa tatatatgta
    11101 taagtttatt ctgcgtgagt agaatggatt tgtcaagttt aatttagttg taattctatc
    11161 ttttattaaa aataacataa attaaaacat ataaataaaa tattttatac aatatattgt
    11221 aaaggaggta actttgatga aagcagaaaa aacaagtata tatccaatta ttaaaaataa
    11281 tttaaacaaa atatcaattg ttgaatataa aaagggtcaa agatttgtag catcagataa
    11341 agacttacaa gaagtgttct ttataataga gggagttgca ttagtggagt gtactactag
    11401 aggaggaaat aaatttcttg ttgacattgt acctgaaaat gaatttatag gcaaaattag
    11461 ttacatatat gaacataatt tgaaatgtga tatatttgca aagactaata taaaattatt
    11521 tcgatttgaa aaaaatgtat ttgaagagtt ttatctcaaa ccagatttta ttgcactatt
    11581 tcacagaaaa tgtacaagaa gaatatatga attatataaa accagaatgg taagagaact
    11641 attttcttgc acagaagtta ttgcctattg tatatcaaat aaacaagaaa ataatgtctg
    11701 caatataaaa gctattcgta atttcagtga aatctattca attagtagaa aaagtagata
    11761 ccattctctg ctaaagttaa ctgaaaagga gatagtaaaa aaaatgggta atacatatga
    11821 aattttaaac tatgatgaat tacataaatt ggcatttgaa gtaaaagaat ttttggaaga
    11881 tgagtaaaaa ttgttactta atcaaaataa agtataataa tttctgtaaa aaatagaaat
    11941 agtctcactg aaaatcaaaa atactttagt tattttcaat gagactgttt agaaatattg
    12001 tatacttata atgtatagta taattattaa tcaatttcct ttactatatt aatagcccat
    12061 tttttagata atgctctagg aacaccaaat ataaacttaa ccacttcttc actataagtg
    12121 agcaaaacga gtacaaatat aggtgcacct ttaaatgcag ctataaaagt tagaggaata
    12181 gaagctaacc acatacatcc taattctaaa aatagagcat atttagtatc tcctccactt
    12241 cttaaaatac caattataac caatgtatta aaagatttaa gagccattag tattcccatt
    12301 ataaagaata tcttagttat atcagaagct aagctatcag aaacactaaa catttttaat
    12361 aataatggta tatttaaaat taaaataatt ccaagtatta aaccagctga aaatacaagt
    12421 atagaaaact ttttagcata ttcaatggct cttttaatat ggtcagctcc aagttcattt
    12481 ccaagcataa tagatgcacc agatgcaata catacagctg tcattatgaa gaaattacct
    12541 gtactggttg ctatctggct agctgctata gcagaagtac cagctcttgc atatgcaaca
    12601 gaatacagga cagttccaat tgcccataca gagtcattta caaatatagg aaagcttttt
    12661 gatgaaaaag attttataaa aattttatca atagctttta gattttttag accaaacttt
    12721 aatatatagt cttttttata aaggtaaaca taagtaatca ttaaaattaa ttcacatatt
    12781 ctagcaataa cagtagctag agcagcacct tttacaccca atgcaggaag accgaagtta
    12841 ccaaatataa atccataatt taaaataaca tttgttacaa gtgcaaatgc actacaaatc
    12901 atacctaact taggatttct aacacctctt gaaccagtac taaatacagt acttacagca
    12961 attaatggat aactaaatac tgcaatacta aagtaatcta tacaaagttt taccacctca
    13021 gaatcatacg aaaatatgtg tataattggc tttggtgtta gtaaagcagg aataacaaat
    13081 acaaaactta aaacaattgc caatacacaa gtaagacctg tgacttttct tatattactc
    13141 acatccttct ttccataaaa ctgtgaaata aaaactccag cacctcctgt gataccagat
    13201 aaggacatat taaaaagaaa gaaaaattgg tttgcaactc caactgaagc tacagatgtt
    13261 tcccccaaac tacttatcat aattgtatct attacattta cagaagtaga aattaagttc
    13321 tgtatgataa taggtataca taaagataga agtattttat aaaatctttt attttcgtct
    13381 tttaaagaaa atagttcttg caaataatcc tctccttttt acataaattc ttcccactca
    13441 tcatatagag aggcaaggtt attttctaaa ttaatttttt cttggctaac ttctttagct
    13501 ttatctggat tagagtatac ttcttcttga cataaaagta tatctaattt ttcaatttca
    13561 atctctaact tttcaatttc tttttctata ttttgtcttt ttattctatt tttcttttct
    13621 atttctcttt gttctctctc ttttcttttt tcatctttta tttgagttct agttttttct
    13681 tctttttctt ctataatact catctcttgg atttgccttt ttttatctat ataataatca
    13741 taatttccca gatattcagt aattccattt tcatctaaaa ctaaaatttt atcaacaaca
    13801 gtatttagaa agtatctatc atgtgatatt gtaaatatag tcccatcata attagttaag
    13861 gcctcttcaa ggacttcctt agaatcaata tctaggtgat tagtaggctc atctaataac
    13921 aataagtttg catttgatag tataagttta agtatggcaa ctctagctct ttctccacca
    13981 ctcaatgtag aaatcttctt aaaaacttct tcatctacaa ataaaaatgc ccctaacata
    14041 tttctcaaag tagtttgagt aagatgagta ttattttccc aaatctcatc aattattgtg
    14101 ttatctaaat taagagtttt ttgttcctga tggaagtagg aaacatgtac attagttcca
    14161 aatttaatat tgccactaag aggttgtagt tcattagtta ttattttaaa taatgtagat
    14221 ttgccaacac catttgcacc tataagtgca actttttccc ctctatatat atctaaatcc
    14281 aagtctttaa aaagtattct ttctccataa cccatagata catctctaat ttgaagaaca
    14341 tcattaccac tctggacaga aggcgtaaat tgtatacgag cttttttcct ataagcttct
    14401 ggtttatcta aaacatctac tttgtctaat gctttttctt tacttcttgc acgctttagg
    14461 tgtttttctc taccataagc ttttagtctt tcaattgatt cttcttgctt ttttatttct
    14521 ttttgttggt cttcaaattt cttaagctct agttcttttt ctattttaga taactcaaca
    14581 aatttagagt agttaccatt atatacttta agctttttat tgtgaacttc aaaaattcta
    14641 tttacggatt ggtctaagaa atatctatca tgagatatta acatgacagt ccctttatat
    14701 tgttttaaaa atacttctaa ccattctatt gcttcagagt ctaagtggtt agtaggttca
    14761 tcaagtaaca atagagttgg tttcttaaga agtaattttc ctaaaagaac tctagttttt
    14821 tcaccaccag aaagtatgct tattggctta tccatatcat tgtcactaaa tcctaatccc
    14881 tttagaactc ctttggcttc agatttatat ccatatccat ttaaatctga aaataattct
    14941 agtttatgtg aatattcatc catgattttt tctataattg gagagtttgt ttttgtactt
    15001 tcttcagata ttttaacctc caattctctt aaataggatt ccatttctat caaattttta
    15061 aaaacttcta gtacttcttc caaaatagta ttatccgaat aaaaattggt attttgttct
    15121 aaatatccga tttcacaatc tttagaagtg taaatatctc cactatcata tccataaatt
    15181 cctgaaatta ttttaaataa agtagttttt ccagtaccat taacaccgat tataccaatt
    15241 ttatcgcctt catttactgt aaaactaata ttttctaata tagaatctat accaaaactt
    15301 ttatttaagt tattacatga caaaacaatc ataaatttct acctccttga actatctaaa
    15361 attataatgt tttgatataa tataatcaag gttatatgta ttagttttga aaaagaaata
    15421 ttttattgtg aatcaaacaa aaaagaggac acttttagga ggtgaagatg ttgggaaata
    15481 aaaatatatc aatggcagtt ataagaaggc tcccaaaata tcatagatat cttggagact
    15541 tattagatag ggatatacaa agaatatctt ctaaagaatt gagtgatata atagggttta
    15601 ccgcttctca aataagacaa gatttaaaca actttggtgg atttggacaa caaggatatg
    15661 gttataatgt agaagctctt catactgaga taggtaaaat tcttgggttg gatcgaccat
    15721 acaacgcagt tcttgtagga gcaggtaact taggacaagc tatagccaat tatgcaggat
    15781 ttagaaaagc tggattcgag ataaaagctt tatttgatgc aaatcctaga atgataggtt
    15841 taaagataag agagtttgaa gtattagatt cagatacttt agaagacttt ataaaaaaca
    15901 ataatataga tattgctgta ttatgtatac ctaaaaatgg agcacaagaa gttattaata
    15961 gagttgtaaa agctggaatc aaaggtgtat ggaattttgc acctttagat ttagaagttc
    16021 cgaaaggtgt tatagttgaa aatgtaaact taacagaaag tttatttacc ttatcgtatt
    16081 taatgaaaga aggaaagtag acaacttaaa catattaata atgagcagtt gtaaagagta
    16141 ttgagaaagt cagaagattt aatattaaat cctctggctt tttgaaatat taggataaaa
    16201 atttaaataa tgtatggaaa taaacaatat taaggagagt ggtttttgtg gaggaattat
    16261 ggaaaaaggc aattgaattt catggtcatg aatgtccagg gttagctata ggatttaaag
    16321 cagcacttgc agcaaaaaaa tatttaggat gtaaacagtc aggagatgag gaaattgtat
    16381 gtatttctga aaatgatgct tgtggaatag atggtataca agtagtgcta agttgcacaa
    16441 tgggtaaggg aaatttacta cttaggatga ctggaaaatc agtatatcat ttctttaata
    16501 gagaaaatgg aaaatctata aggatatatg taaagtcaaa accatttgag atggatagag
    16561 aaggatacaa aagatattta ttagaaagtg attttgaaga aatatttgag attacagata
    16621 ctaagttaag acttcctgaa aaagcaagaa tatttaaatc ccttaaatgt gaagtgtgtg
    16681 gtgaatttgc atctgagcaa tatataagga ttgaagaagg aaagaaagta tgtcttgatt
    16741 gttttgataa atatgaaaga ttttatgaag agtattaaaa ttataaatta gattaaagtt
    16801 aaaagtatta gatatgtgct aacagtattt taagatgaat taggtagcaa cataataaag
    16861 tatataaata atattaattg aatcatacat aattaaaaag aggctgatta gtatttataa
    16921 aataaaatca gtctctttat gaataacgaa ttattattct ggttgaggtg catctacagg
    16981 acaagctcct gcacaagaac cacagtctat acaagaacca gcatctataa catatgcgtc
    17041 gtctccagct gatatacagc taacagggca ttcagcctca caagcaccac agcttataca
    17101 agcgtcagta attttatatg ccattttgaa atcctccctt ttatatgtat tgtaattcaa
    17161 taacattata acaaatatta ttgaatataa caattaaatt aattctacaa caaaaacttt
    17221 attatgatat tcttgtttta aagttttaca ataaagttta atctgcttat atttttattt
    17281 attttaaaga agtttatttt aaaaataaaa ttaaatttaa aaagttatgt attgattata
    17341 tttaaaaatg ttatactcta aaaaagtata ttttatttaa aaatttatta atacaaagga
    17401 gatttactat gaaaaataaa ttagtttaca tatgtattat gagtctattg ctatttgtag
    17461 taggatgttc taataatcca aataaggaaa gtaccattaa aaaagactct aagaataacc
    17521 aaagccaagt taaagaagaa aaaagagaac ctgtgaaaaa agatataact ataagtttcg
    17581 ctggtgatgt aactatgggg aactataaag gttcatcata ttatggcagt tttgaccatg
    17641 aatttaaaag acaaggagaa gattacaatt attttcttaa aaatgtaaaa cctgtatttg
    17701 aaaaagatga cttaacagtg gttaatttag aaggtccact tactacagcg tcaaatgcaa
    17761 aagaaaaaaa atttgcattt aaaggaaagc ctggatatgt aaatatttta aaatctggaa
    17821 gtgtagaggc agtaagtatt gcaaataatc attcagaaga ttattttgaa gaaggaatga
    17881 aagatacaca gtttatattg gacgagaata aaataaatta ttttggatta gggaaagatg
    17941 ctgttgtaga tgtcaaagga attaaagtgg gtctattagg gtataatgga ttatcaactg
    18001 aatataatga aaaaaattta aaacaaatgg aagatgatat taagtcctta aaaaagaaat
    18061 cggatgttgt tgtagtgtac tttcattggg ggatagaatt agattattat ccagataaaa
    18121 aacaaaaaga ttttgctcat tatgctatag acaagggagc agatttagtt atggggtctc
    18181 acccacatgt gattcaagga atagaaaagt ataaaaataa gtatatagct tatagtctag
    18241 ggaatttttg ctttggagga aataagaatc cttctgatac agatagttat atatatcaac
    18301 aaacctttac tttttcagat aataaattaa cttcaattaa agagccaaat ataataccaa
    18361 cttcaataac atctagtaac tccagaaata attatcaacc aaaaatattg gatggaagtg
    18421 agaaggatag agttttaaat aaacttgaaa aaataagcaa agatttaaat aaataaaatg
    18481 taaaaaaaaa taaatatata tatttatttt aataatttat attttgttta gggtatggta
    18541 aatcgtggta ttaaataagt agattttaat agttaaatta tagtcaatta taataaagct
    18601 atttaatcta cttttttaat ataaaaatat aagggggaat ttgtaatggc ttgtaacact
    18661 tgtaaaatgt gcgaaagtgc agacaagaaa ttagaaagtt ttgtagcttc aaaggatgtt
    18721 gaaacagcat ttcatagaac agaagatcag aaagttaagt gtggttttgg acttcagggg
    18781 gtttgttgta gactctgttc aaatggacca tgtagagtaa ctcctaaatc accaagaggt
    18841 atatgtggag cagatgcaga cactatagta gcaagaaact ttttaagagc agtagcatca
    18901 ggagcagctt gttatttaca tgtggtagaa aatacagcta agaatttaaa aaatgttgga
    18961 ataactaaag gtgttgttaa aggagaaaaa acattaaatc aattagcaga gatgtttgga
    19021 atagaaagtg atgaaaagta tgataaatgt ataaaggttg cagacaaagt tatcaacgat
    19081 ttgtataaat caagagatga taaaatggaa ttagtagaaa aaatagctta tgcacctaga
    19141 gtgaaaaagt ggaaagagtt aggtataatg cctggtggtg caaagtcaga agtttttgat
    19201 gcaatagtaa aatcatcaac aaatttaaac agtgacccag tagacatgct agttaattgt
    19261 ttgaacttag gtatatcaac aggattatat ggtcttacac taactaatct tttaaatgat
    19321 gttatgttgg gagaaccagt tataagaatg gctcctgtag gatttaatgt aatagaccca
    19381 gactacataa atataatgat aacaggtcat caacattcaa catttgcaaa tttccaagat
    19441 agattaaaag atgaagatgt tataaaatta gctcaatctg ttggcgcaaa aggatttaag
    19501 ttagtaggat gtacatgtgt tggtcaagat ttacaattaa gaggagaaca ttatcaagaa
    19561 gtatttgctg gacatgcagg taacaatttt acaagtgagg ctgttttatc aactggagca
    19621 atagatatag ttctttcaga atttaactgt actataccag ggcttgaacc aatagcagat
    19681 aaatataaag taaaaatggt ttgtttagat gatgttgcta aaaaagcgaa tgcagaatgc
    19741 ataggtttag acagaagtaa attagatgaa cttagtaaca ctttaataga aaaagcattg
    19801 gagtcttata aggagagaag aggaagtatt gaaatagata taccaaaaga ccatggattt
    19861 gaacaatctt tgactggtgt aagtgaaaag aacttgaaag cgtttttagg agattcatgg
    19921 aaacctctta ttaatttaat tgcagaagga aaaattaaag gtgttgcagc tgttgtagga
    19981 tgttcaaata tgacagcagg aggacatgat gtaaatactg ttgaacttac taaagaattg
    20041 attaaaaaag atataatagt actatctgca ggatgttcta ctggaggatt agaaaatgtt
    20101 ggtcttatgt cacctggagc agaagaattg gcaggagaaa acttaaaaga agtatgtaag
    20161 actttaggaa taccaccagt attaaacttt ggaccatgtc tagctatagg aagactagaa
    20221 atagtagcaa cagaattagc agctgaactt ggaattgacc taccacaatt accattagtg
    20281 ctttcagctc cacaatggtt ggaagaacaa gcattagctg atggagcttt tggtcttgcc
    20341 cttggcttac ctcttcattt agctttacct ccatttataa caggaggaaa attggtaaca
    20401 gaagtattaa cagaaaaatt aaaagactta acaggaggac atgttatagt gaatccagac
    20461 cctaaatctt cagctaatca attagaagaa ataataatag atagaagaaa aaatttaggg
    20521 ttaaaggatg tggaatgcaa tgcatagaat ttttataaat aaagatttat gtacaggatg
    20581 taagagctgt gtactagcat gtatgctaaa acacaataaa gattatgaca tgtacactct
    20641 tgatttagaa aatatagata atgatagtag agggcatata gaattagata gtagacataa
    20701 taatccagtt ccaattcttt gtagacactg tgatgaacct gaatgtgtat tagcatgtat
    20761 gagtggtgca atgcataaag atagtgaaag tggaatcgtt tcatatgatg aagagaaatg
    20821 tggttcatgt tatatgtgtg taatgtcttg tccatatgga ttattaaagc cagatgatag
    20881 aagcaagcag aacatactta aatgtgattt atgtaaagat gaggagtatc ctagatgtgt
    20941 agctaattgc ccaagtggag caattgaatt acagaaggag gaaaatgatg aattatgtag
    21001 tgttaggggc tagtgcagct ggtataaatg cagtaaaaac attaagagaa ttagataaag
    21061 attcaaatat agtagtaatt tctaaagatg aaaacgtata ttcaagatgt atgttgcatc
    21121 acgttatatc tgaacacaga actttaaaac aaataaattt tgttgatgaa gattttatgg
    21181 agcaaaataa tgtaaaatgg attgcaggta agactgttaa aggtatagac ataaataaaa
    21241 aggtagttca gacagaagac attactgtaa attatgataa acttttaata gctacaggtg
    21301 catcttctgc tattcctcct ataaaaaatt taagagatgg aaattttgta tattctgtga
    21361 gaaacataga tgatatttat aaaataaaag aaaaagcaca aaattctaaa aatgtagtta
    21421 taataggtgc tggtttagtt ggtatagatg cattagtggg attatttaaa tatgagcagt
    21481 taaatatttc tgtagctttt atggaaaagt acattttaga tagacaattg gatgaatata
    21541 cagcatcagt gtatgaaaat aagttcaaag aaaaaggtgt aaaattttac ccaagtgcat
    21601 caatacaaga aattgtattg gataacagta aaaatgttac aggtgttgca ttttcaaatg
    21661 gtgaagtttt agatgcagac atggtaattg tagctacagg ggttaaacca aatgctgact
    21721 ttttagatgg aacaggaata gaatatgata gaggtataat aatagatgat atgtgccaaa
    21781 caacacaaaa agacatatat gcagcaggag atgttgtagg taaaaatgct atttggcctc
    21841 tggcagtaaa gcaaggaatt gtagctgcct ataatatggt tggaaaagat aagaagatag
    21901 aagatgaatt tgcttttaaa aatagtatga atttcatgga tataccaact atttctatag
    21961 gaatgaatac acctgtagat gatagctata aagtattaac cagacatgga attaatgatt
    22021 ataaaaagtt tgtttttaaa gataatgtaa tctatggagc agttatacaa ggagatattt
    22081 catatgtagg tgtattaact tatttaataa aaaataaagt tgaaatatat gatttagaaa
    22141 ataggatatt tgatatatgt tatgcagact tttttaatat aaaagaaaat ggagaatttt
    22201 gttatagtgt atagtatata cgtggagtaa ggtttataa
//
LOCUS       DAEPID010000065        22139 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.065, whole genome shotgun sequence.
ACCESSION   DAEPID010000065 DAEPID010000000
VERSION     DAEPID010000065.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 22139)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 22139)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..22139
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.065"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            154..936
                     /locus_tag="KR257_002774"
     CDS             154..936
                     /locus_tag="KR257_002774"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009901671.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CPBP family intramembrane metalloprotease"
                     /protein_id="HBH0031454.1"
                     /translation="MMILPLSSVSIAKFYTEGRNNDKYNFYSSVILFFIIYFFIFIIE
                     SLKLISINQFQLMYLMLILISSLCVIVYSYKITSLYIFKNFKIGILLFFYFLFSQIIF
                     GLIISDNQFDYKNFLNYILLPIISLVYIYPFLCEEYGWRSFLQSILFDRFGKKIGIVM
                     VGTCWSLWHLPLQFTLYSPQTPIIGAIANLIYGIGLSIFLGYVYMKTKNIWFCSIMHV
                     LINSLGLIFNDSEIIINYHSIIQRLIFILLFYTPFLFTKEYK"
     gene            1316..2842
                     /locus_tag="KR257_002775"
     CDS             1316..2842
                     /locus_tag="KR257_002775"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423262.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="FAD-dependent oxidoreductase"
                     /protein_id="HBH0031455.1"
                     /translation="MNESYWFLNSSPKEYNKLGENIKTDCLIVGGGITGLTTAYLLAK
                     EGKKVVLVEADKIGYGTSGRNTGKVTCQHDIFYSKIEKKYGLDKAKSYYNANNEALNL
                     VEQIIEENNIKCDFKRETSFVFTEKEDTIKDIKDEYRTCKKIGINCEYHETIENIPLD
                     IKGAISFTNQGQFNPKKYIDGLAKAAVNLGLKIYENTPVVDLEKGKICRVKTREDNII
                     EAENVIISSHSPWYDGLNFYFAKEYAERAYLMVAVLENKLADGMFISIDDPSITFRQY
                     NDGSENLLIFGGGDHKVGQGGTEKEIFDDLEHYGKEVFKVKDFKGKWSAQDNMSFDNV
                     PYIGYINKREDNIYVATGFSKWGITNGTAAGIIIKDLIINNNSDYKDTFNPSRLGSYF
                     SKDFIKENANVAINYVSGKLKIGSGDMPKNNGEGKIVNIDGKRYGVYKDDNGDFYIVD
                     TTCTHLGCELNFNSEEKTWDCPCHGSRFDYKGNILEGPALKPLKLYGHGDNDVNPKLL
                     "
     gene            2870..3427
                     /locus_tag="KR257_002776"
     CDS             2870..3427
                     /locus_tag="KR257_002776"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003440252.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0031456.1"
                     /translation="MNKLLKPITILLYIVYILSAVFFVANKEYGSLGLVAISLVGTFI
                     LSFINKQTERLLSKELYIMLALFIMFSSLLGTCFNFYDINYYDDFLHLWSGIISCIVA
                     FSIIKYFYTQREISKMSKVFLVIFLFMFSMGVASLWEIGEFLMDTFVGTTTQAGGLED
                     TMIDMVDALIGTIITIPFIVKKSNI"
     gene            3949..4992
                     /locus_tag="KR257_002777"
     CDS             3949..4992
                     /locus_tag="KR257_002777"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430405.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0031457.1"
                     /translation="MLKKWFGIVKKRQKSESAKEEGEVILKNEKILSEEKLIDEEGVV
                     VNIDNEILTKVEVVNDDNEIEEKIIEEDWLISENTIKLDDKEAIINDKNIELCKKEVQ
                     VESEKIGLNKFEGLDQNENYNLEKNVIEEKKVSECLTEEDLEYIKEIKIKRGKSIKAI
                     NLYTKEEWVFDTHIQCSKKLKVPLGYIRENLKYGYMDYFGDAINYLSEVLNIDEYCKS
                     EWSYLDNSKSPSEIFNILNNKIFSIRLSNEKRNEILTNDKIEALKMNYRFECIDEEYD
                     EYFKKYKSIIKRGGKKKVELVNKKGDILEIFKSLEECAIYLQKEKNEVIQMLKYGDTK
                     VGRNFIRYSLRSI"
     gene            5103..6245
                     /locus_tag="KR257_002778"
     CDS             5103..6245
                     /locus_tag="KR257_002778"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003440250.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptidylprolyl isomerase"
                     /protein_id="HBH0031458.1"
                     /translation="MSEEKNPKENTLDESKNSDNVNSKKDDVSDEKNTDNKVKKREIK
                     LNNKTLKAIVAIVAVGAICLGGGYVFGKEAGRKLPATSKHYNSSEVVATIGDKKITGE
                     MLRKRMEPLFYLNAKTTMTDDEIRSYESNMIETMITSDILSSEAAKEKISITNDQLDA
                     QYNNLMSSIESAMGMTKEEFLKQFDLTEKYIKDDMKKELVASKYLNEKSKVTDKEAEN
                     YYNKNKSNYLQVRASHILIKTVDDKGKQVSSSKKAELKKEAEEILKKAQAGEDFATLA
                     KKYSEDSSAESGGDLGFFGKGQMVESFEKAAFALKKGEVSNKLVESDYGYHIIKKTDE
                     KYQPFEEVKSDLVSSLTSEKQNLLIQNLKEKYNVKITDKYQMKAKE"
     gene            6699..8090
                     /locus_tag="KR257_002779"
     CDS             6699..8090
                     /locus_tag="KR257_002779"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430410.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptide MFS transporter"
                     /protein_id="HBH0031459.1"
                     /translation="MSSTESVSKKSGHPKSFWLICMTILWERFSYYGLTALLVLFFTA
                     SVAQGGLGLSTQEATSMFGLFTGLIYLTPLVGGWLADKVLGQQKCISIGALLIAIGDF
                     VLFASSTSIAMVWVGLSIIILGNGFFKSSCSNIVGDIYPKTDVSRKDAAYSLFYMAVN
                     VGAFIAPIICGLLSDNVFAVRGASGDIVSYGYKMAFLICGIGMMLGMIIFTLLAPKLL
                     NEVGKYPVTKGNKGEKIEYGPLTKLEKNRIIAMVILFLFVVLFWTAYYQTQSSFMIYV
                     RDNVNRTLFGFEMPVAWLTSLNAILCVALCPVLATLWVKLSHTKRGDFSIPVKMGLGM
                     IIMGVGFIVMVFATLANGPDGMVKASILFIVLTYIFTTVGELFLSPIGLAMFNKLAPA
                     KYATLSMGAWYLTSFFASLLSGKIAGFTATLGFLQIFGGIATVLIIFGLILLGIRNVL
                     TRLMAMDLLTKEK"
     gene            8343..10136
                     /locus_tag="KR257_002780"
     CDS             8343..10136
                     /locus_tag="KR257_002780"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003440248.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aminopeptidase P family protein"
                     /protein_id="HBH0031460.1"
                     /translation="MNIKDRLSGLRKFMEEKNIDAYMIPSSDNHQSEYVGDYFKSREF
                     ISGFNGSAGTVIVTKDEAGLWTDGRYFIQAESQLEGSTIKLFKMGQEGCPTTDEYLYK
                     NIPEGGTLGFDGRVISAREGATLAEKLSKKGIKIEYQYDLIDSIWPDRPALSDSKAFL
                     LDVKYCGESFSSKLARLREKMSEKGTSTHVITTLDDIAWLFNIRGGDVKYNPVVLSYA
                     VITLKEVYLFVDESKLNEEILNELAKENVQIKPYNDVYEFVKNIDKTEKVLLDGTKLS
                     YTIYNNIPCEVEKVDEFNPVMFFKAQKNEVELENIRNSHVKDGVAFTKFMYWLKKNVG
                     KMEITEISATQKLEDLRREQEGFFEPSFNTIAAYKEHAAMMHYSATPESNYKLEAEGL
                     FLVDSGGQYYDGTTDITRTTVLGPISDELKLHFTSVARGMINLSKAKFLHGCRGYNLD
                     ILSRSCMWNMGIDYQCGTGHGIGFVLNVHEAPNGFRWRVVPERFDSAVLEEGMVTTNE
                     PGIYIEGSHGIRTENEIVVRKAEKNFYGQFMEFEVVTLAPIDLDGIVPELMNKDEKDY
                     LNWYHKLVYDKISPFLTDEEREWLKVYTRAI"
     gene            complement(10217..11599)
                     /locus_tag="KR257_002781"
     CDS             complement(10217..11599)
                     /locus_tag="KR257_002781"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430415.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptide MFS transporter"
                     /protein_id="HBH0031461.1"
                     /translation="MSVLKTQEKLKQPRDLYFCCSIFTFVGLAYYGMKLVLLLFLAEQ
                     VSKGGLGLTPAESASMLASFLAWTYFSPVIGGWVSDRFLGPKNCIILGMLMVSIGYFL
                     GYIANSKMDINIMIFLSGLGIGFYKGNLHTMVGNLYTNDDPRKDGAFSITYMATNLGT
                     LFGPLICGLVANEWFAMKSGLSISMYGYRYVFLFSSITVLIGLFFFIFGNRKFYKPLN
                     NDPSNGRESIRKSLEYKKMLASRPLTLIEKKRIIVILVLAFFTVFFWIAYNQASMSIA
                     LYTKEHINLTVGNFQIPTSWIDSYNGLLCVILGPISALVWVKLSQTKKGDLSVPKKMS
                     LGFILLAIAFLFMIVAVIQTGTDPNSIHKASVFWVVGFLTFQSIGEICFSPVGYGMVN
                     KLSPEKYISFLMGVWFLGKFAANKLSGYTQAIIDQLGMLQVFIVIPSFLLIFGIILLI
                     MNKKLVELSN"
     gene            11857..12204
                     /locus_tag="KR257_002782"
     CDS             11857..12204
                     /locus_tag="KR257_002782"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423269.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cupin domain-containing protein"
                     /protein_id="HBH0031462.1"
                     /translation="MIRKKSELQVEVKENLNGGIGKVKLENIIQNEELKGKGRLFKRV
                     ALPVGSSIGVHDHTTDFEVYYILKGKGKVFDNGEFVEVNEGDVVYTADGEKHSIENIG
                     EEDLEFVALVLYM"
     gene            12222..13256
                     /locus_tag="KR257_002783"
     CDS             12222..13256
                     /locus_tag="KR257_002783"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003440238.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0031463.1"
                     /translation="MTGKIEEIKDKINRFCNSNLNQEYKDISFKILQNLLDNNKEIIH
                     SSRADIWSSAILNIVLEQNLLYNKKHPLHITKKEFSKQIGVSLNTINNKSSLIKDVCS
                     IDFLNQDTIAISNVEFWVKETNSKSKSVDLDLEKKKILYKRYIKLSQDANSDIESIRY
                     MEEAVNIGKSMITKEDKELGFWKGLSTRAYMIALESLARKLESINNLKESKKVLEYLI
                     EINPSDEQGIRYKLLNVLIRLNDRTSINKLFELYKEEKSATWMYSKALYYFKNKSMFL
                     ANDSIKVARSKNKYVGLYLLDWRNAFGREFVTEEEKAEAVYYYDENIVIWNEVKGSMD
                     WLLKKMLEFS"
     gene            complement(13305..14354)
                     /locus_tag="KR257_002784"
     CDS             complement(13305..14354)
                     /locus_tag="KR257_002784"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003440236.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIC"
                     /protein_id="HBH0031464.1"
                     /translation="MEINYKKRNFKSFAKRKNIEISVQRYLIDALSYMALGLFSSLLI
                     GTIFNTLGDNFNISLFTEVISPLAKQVTGPAIAVAIAYGLQAPPLVLFSCALVGACGN
                     ELGGPVGAFVATLFAVEVGKLVSKETKIDILVTPAVTILIGVLVAELIGPAVSAFMTS
                     FGNIIMQATTMQPIIMGALVSALVGIALTLPISSAAICMMLSLGGLAGGAATVGCCCQ
                     MVGFAVMSFRENGVGGLVAQGLGTSMLQVPNIIKNWKIWIPPTVASILLGPLSTTIFK
                     MENIPIGSGMGTCGLVGQFGTVTAMQSAGKGGISMWVGILLLNFILPAIVTLLISEFM
                     RKKGLIKPEDLKLDV"
     gene            14629..16164
                     /locus_tag="KR257_002785"
     CDS             14629..16164
                     /locus_tag="KR257_002785"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430424.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0031465.1"
                     /translation="MIFVKNKKYRKIAIIISIPILLVAQYYLFKFGILRPMVKGVEIE
                     IVDGEYVKDIDKYVVKLNETVTLSTGEYIKVPSYAKNPNIWFNVLDNSGTLKIDGNKM
                     TALKVGYSSVGIMKNSRVLKKATIKVVDPEVESLDMEINGDLKHVGDSATIESTIEVD
                     YDKFKKSYKPVYKSSNENILKIKGNKVSAVGVGKATIYAKCGNKEIERTFRIQARVAE
                     INMDDIKIEVDQNEKLKPDIITSPPGLEPPKIYYELVDSKLPVERAISLSSNGNVVGL
                     REGKDRVRITCGDKSKVITVTVVKETITNDYIQNLVGSHKIVNNKVIIKLEWDYMKDV
                     FDYDIYLKDKLSGESFKKIKSITINESDLGKSNKVYATIEVDMKGNQNIDFDIYVIGK
                     KDSDTTKPSNVINITNGNGNSNNDNNIKDMRVENISANVDRDNNVIRVNWSSISHKDC
                     TYSIYVKNNTNGDGEFTLYQSDIQGNEHTISIPEGDLNLDIYVVANYNGNSSQNSDVI
                     NVR"
     gene            complement(16349..17035)
                     /locus_tag="KR257_002786"
     CDS             complement(16349..17035)
                     /locus_tag="KR257_002786"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003440228.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aspartate/glutamate racemase family protein"
                     /protein_id="HBH0031466.1"
                     /translation="MKTIGLIGGMSWESTITYYQVINTVIKERLGGLHSSKCILYSVD
                     FQEIEECQSSGNWEKSAKILADAAIKLQEAGADFIVICTNTMHKVSDKIQESIHIPLL
                     HIADVTATVLREKEIKKVALLGTKYTMEQDFYKNVIINNGIEVLIPNEEDRIIVNDTI
                     FNELCLGIISESSKKAFLSIIDKLGKQGAEAVILGCTEIGLLIKQNDTSIPLFDTTVI
                     HAIEAALSSI"
     gene            17160..18542
                     /locus_tag="KR257_002787"
     CDS             17160..18542
                     /locus_tag="KR257_002787"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729078.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PLP-dependent aminotransferase family protein"
                     /protein_id="HBH0031467.1"
                     /translation="MPINSFENYPMTWKPKLDNRKPPIYKTLAMLLEEDIKRGNLNPG
                     DKLPPQRELADFLDLNLSTITRAFKLCEEKGLICAKVGKGTFISSDVNVSNTLLYQTE
                     SKDIIELGTVHPPYEQNTYIIDFIKNVLKQPEMDRFLQYMSPSGTYMQKKSIAKWIER
                     NNVYTSEENILLSTGGQNAICATLLGLFKAGDRIATDSLSFSGIKSIAKMIGIQLVPI
                     PQENNEISIEYLESYCKNENIKGIYLIPDYHNPTTHTMSDLSRKKIAKIAKQYNIIII
                     EDAINSIFRDGIQTPIFSLASDNTIYIFSTSKFLCAGLRVAFVVAPKRYIENLENALY
                     NMNLMVSPFTAEIVHRLLYSPIIDKIIEEKRDAIIERNEVADKVLSDYNLIGDKNCSF
                     RWLLLPDELDGKSFEISAKNLGVQVYCAERFSVGNSTVPKAVRICVTAPKDVEELEKG
                     LNIIKSLLKS"
     gene            18944..20212
                     /gene="eam"
                     /locus_tag="KR257_002788"
     CDS             18944..20212
                     /gene="eam"
                     /locus_tag="KR257_002788"
                     /EC_number="5.4.3.9"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430434.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glutamate 2,3-aminomutase"
                     /protein_id="HBH0031468.1"
                     /translation="MNEQTRISLERAAELKSKIDDYIQARKTINRGLEKEEEINKRKQ
                     KILSILNGTEEDWNNYKWQLSNRITDVDTLSKIITLTKKEKEYIKEVGTQFRWAISPY
                     YLSLIDPEDICDPIKLLSIPTHIELEDEQEDLDPMGEEYTNPAGCITRRYPDRLIINV
                     TNECAMYCRHCQRRRNIGQQDSHKSKAIIQESIDYIRENEEIRDVLVTGGDALTLKDD
                     YLEWILSQLKEIPHVDYVRLGTRTLVTMPQRITDEFCNMLKKYHPVYINTHFNHPMEI
                     TKESKEACEKLANAGVPLGNQAVLLNGINNDKFVMRCLNQELLKIRVKPYYIFQSKHV
                     KGTKHFNTSVDDGLEIMEYLRGYTSGMAIPTYIVNAPKGGGKTPLLPQYLVSKGTDYV
                     MLRTWEGKVIKMEDEPAVDIKKLIKEQAQD"
     gene            complement(20305..20661)
                     /locus_tag="KR257_002789"
     CDS             complement(20305..20661)
                     /locus_tag="KR257_002789"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890447.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0031469.1"
                     /translation="MKKALISLLVLSCLLLTAPVNESSYADSQKNVPVSQNTKLTQEQ
                     AKELLVKYNNEVDYIYQGNASDFEALKAKNLNGYVFLPDADGDIGYFVNENTSEIYYF
                     HPSGYLELVNQQQNNK"
     gene            complement(20812..21906)
                     /locus_tag="KR257_002790"
     CDS             complement(20812..21906)
                     /locus_tag="KR257_002790"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423290.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AI-2E family transporter"
                     /protein_id="HBH0031470.1"
                     /translation="MQDKKIYLNIVLTVVVSYILIKVIDNYKYFFGVISLLMSLLTPF
                     IIAFVLAYIFNPLVKFLESKLNFKRIYSLLLTYGVLIVILISFILFTVPSIVNSLADL
                     VAQIPTYIDKTEQFLFDLGKSLQSVDPNTLKEYGDKIMSVMPKFSNLLIGSLGGIFST
                     TFSVGKFIVQFLLGFIICFYILLEKEKFLLFTKKVVYISLGKKYGDFIIELCQSLNLN
                     IGKYFTGKILDSFIVGVLSGIGLYFLKSEYALLFGTLMGVMNMVPYFGPVIGMAPVVI
                     INLFSNPTIALTSLIYLIIIQQVEVTFIEPKIVGGQLGLSPFFTILAVTVGGGFFGIP
                     GMILSAPVMGVIKIYFCEFVNRRHDKIQME"
BASE COUNT         8753 a         2469 c         3581 g         7336 t
ORIGIN      
        1 tttttaaagc caacatatgt cagtgatgaa ataaaaagaa aaaaactaca agttataata
       61 tttttttcta taacttatgg tttatcttat tcactaggtt tattagcaat atgttttaat
      121 catttaatag attcagaaat tttagctcaa tttatgatga tattgccatt atcttcagtt
      181 tctattgcaa aattttacac agagggaaga aataatgata aatataattt ctattcatca
      241 gtaatattat tttttattat ttactttttt atatttatta ttgaatcatt aaagttaata
      301 agtattaatc aatttcaatt aatgtatctt atgttaattt taataagtag tttatgtgtt
      361 attgtttatt cttataaaat aacaagttta tatattttta aaaattttaa gataggtatt
      421 ttgctatttt tttacttttt gttttctcaa attatttttg gattaataat aagtgataat
      481 caatttgatt ataagaattt cttgaattat attcttcttc ctataatatc attagtatac
      541 atttatcctt ttttatgtga agagtatggt tggagatctt ttttgcaaag tattttattt
      601 gatagatttg gcaaaaaaat agggattgta atggtaggca cttgttggag tttatggcac
      661 ttacctttac aatttacact atatagtcct caaactccaa taattggagc tatagccaat
      721 ttgatatatg gtattggact ttctatattt ttaggttatg tttatatgaa aactaagaac
      781 atatggtttt gctctataat gcatgttcta attaatagct taggattaat ttttaatgat
      841 tctgaaataa ttattaatta ccatagtatt atacaaagat tgatatttat actattattt
      901 tatactcctt ttctatttac aaaagaatat aagtaagaat tacaattaat ttatataaaa
      961 taaattttta agtaaatatt tttatagaga gattgttata ttacatatca gaaaaatatt
     1021 aaactaacta aatcaataaa aaagttggtg gataacaatt tataattgtt agcacaacat
     1081 catcttatgt attgaaatct aaaatatcct catttttact tagcataaat actattaatt
     1141 aagaaaataa tatagaaatt ataaatatat ataagtttag tctggtgtat aaaacaagaa
     1201 aactaagtga tttttaattt aactttttat taagcttatt ttttatacta tttataataa
     1261 ataaactcca tgatgggaaa actattacta tttaatatgt aaaggagtat tttaaatgaa
     1321 tgaatcatat tggtttttaa actcaagtcc aaaagaatat aacaaattag gtgaaaatat
     1381 aaaaacagat tgtcttatag taggtggtgg aataactgga ttgacaactg catatttatt
     1441 agcaaaagaa ggtaaaaaag tagtgcttgt tgaggctgat aaaataggat atggaacttc
     1501 tggaaggaat actggtaagg taacttgtca gcatgatata ttttactcta agatagagaa
     1561 aaaatatgga ttagataaag caaaatcata ttataatgca aataatgaag ctttaaattt
     1621 agttgaacaa ataatagaag aaaacaatat aaaatgtgat tttaaaaggg aaacttcttt
     1681 tgtatttaca gaaaaagagg atactataaa ggatattaaa gatgaatatc gtacatgtaa
     1741 aaaaatagga ataaattgtg agtatcatga aactatagaa aatattccat tagatataaa
     1801 gggggctatt agttttacta atcaaggtca atttaaccca aagaagtata ttgatggatt
     1861 ggcaaaagca gcagtaaatt tagggctaaa aatatatgaa aatacaccag tagtagacct
     1921 tgaaaaagga aaaatatgta gggttaaaac aagagaggat aatataatag aagctgagaa
     1981 tgttataatt tcatctcata gtccatggta tgatggattg aatttttatt ttgcaaaaga
     2041 atatgcagag cgtgcttatt taatggttgc agttttggaa aataaattag cagatggtat
     2101 gtttataagt atagatgacc catcaataac ttttagacaa tataatgatg gaagtgaaaa
     2161 tttactgatt tttggaggag gagaccataa agttggtcag ggaggaactg agaaagaaat
     2221 atttgatgat ttagagcatt atggtaaaga agtctttaag gtaaaagatt ttaaggggaa
     2281 atggtctgct caagacaata tgagttttga caatgttcct tatattggtt atatcaacaa
     2341 aagagaagac aatatttatg tagctacagg gttctctaaa tggggaatta ctaatggaac
     2401 tgctgctgga ataataataa aagatttgat aataaataat aattctgatt ataaagatac
     2461 ttttaatcca tccagattag gtagctactt ttcaaaagat tttataaagg aaaatgcaaa
     2521 cgtagcaata aattatgtaa gtggaaaatt aaaaataggt agtggagata tgcctaaaaa
     2581 taatggagaa ggaaagattg ttaatattga tggaaaaaga tatggtgtat ataaggatga
     2641 taatggagat ttttatattg tagacactac atgtactcat ttaggatgtg aacttaattt
     2701 caacagtgaa gaaaaaacat gggactgtcc atgtcatggt tctagatttg actataaggg
     2761 aaatatactt gaaggaccag ctcttaagcc attaaaactt tatggacatg gtgataatga
     2821 tgttaatcct aagttattat aaaattattt ttaggaaggt aaagtgtata tgaataaact
     2881 tttaaagcca ataactatac tattgtatat agtttatatt ttatctgccg tattttttgt
     2941 agcaaacaaa gaatatggaa gtctaggtct ggtagcaatt agtttagttg gtactttcat
     3001 tttgagtttt ataaataagc aaacggaaag attattgagt aaagaattat atataatgct
     3061 tgctttattt ataatgtttt catcattgtt aggtacttgt tttaattttt atgatataaa
     3121 ttattatgat gattttttgc atttatggtc aggtataata tcttgtattg tggctttttc
     3181 tataattaaa tacttttata cacaaagaga gataagtaaa atgagtaaag tgtttttagt
     3241 tatattttta tttatgttta gtatgggagt agcgagttta tgggaaatag gtgaattttt
     3301 aatggatact tttgttggga ctactacaca ggccggaggg ttagaagata ctatgattga
     3361 tatggtagat gctttaatag gcacaattat aactattcct tttatagtaa aaaaatctaa
     3421 tatatagttt taaatttttt atattaatta taatggattt aattaatcat gttgagtttc
     3481 aaggtctata tgattaatta aatccatttt tgttatttat aattattatt gaatatattt
     3541 ttacatataa gatataaggt gatagataga aattgttgga ttatgtaaat aattaatata
     3601 taataccatt atgggcaata aatacaaatc aaatgataat atagtctatt tatgtaaatg
     3661 ttatattgta tactaagtat aatagtaagt tttttgatag tggtgtagaa agtaaaaatc
     3721 tactagccta aattgatgta tggattagtt taggaacagt aattgcatat cttaagtttg
     3781 atgtcatgtt gggctactag aaataggtca tctttttcac ttgaatatct tttctttaaa
     3841 catggagagt atcatatcaa aaacatatga aaattaagtg atttataaga acagtaatat
     3901 tttatatgat agtatagaat agtaataaag tattaggagg aacattgagt gttaaaaaag
     3961 tggtttggta ttgtgaaaaa aagacaaaaa agtgagtcag caaaagaaga aggtgaagta
     4021 atattaaaaa acgaaaaaat attatctgaa gaaaagttga tagatgaaga aggagttgta
     4081 gttaatattg ataatgaaat attaactaaa gtagaagtag taaatgatga taatgaaata
     4141 gaagaaaaaa taatagaaga agattggtta attagtgaaa ataccataaa attagatgat
     4201 aaagaagcaa ttattaatga taaaaacata gaattatgta aaaaagaagt tcaagttgaa
     4261 agtgaaaaaa taggtttaaa taagtttgaa ggacttgacc aaaatgaaaa ttataatcta
     4321 gaaaaaaatg ttattgaaga aaaaaaagta agtgaatgtt tgacagaaga agatttagag
     4381 tacataaaag aaattaaaat aaaaagagga aaaagtataa aagctataaa cttgtatact
     4441 aaagaagagt gggtttttga cactcatata cagtgtagta aaaaactcaa agttccatta
     4501 gggtacataa gagaaaattt aaaatatgga tatatggatt actttggaga tgcaataaat
     4561 tatttaagtg aagtattaaa tatagatgaa tactgcaaaa gtgaatggag ctatctcgat
     4621 aatagcaaat ctccatctga gatatttaat attctaaaca ataaaatatt tagtataagg
     4681 ctttctaatg aaaaaagaaa tgaaattttg acaaatgata aaattgaagc attaaaaatg
     4741 aattatagat ttgaatgtat tgatgaagaa tatgatgaat attttaaaaa atataagtct
     4801 ataatcaaaa gaggtggaaa gaaaaaagtt gaattagtaa ataaaaaagg tgacatttta
     4861 gaaatattta agtctttaga agaatgtgcc atttatttgc aaaaggaaaa gaatgaagtt
     4921 atacaaatgt taaaatatgg agatacaaaa gtaggaagaa actttataag gtatagtttg
     4981 agaagtattt aatttcattt taaattcata agagtttcat ttctgattca cacatttaat
     5041 attattttaa tgtaaaataa taaaggtgaa gtattgcaca attaaaatta aggagggtat
     5101 taatgtctga agaaaaaaat ccaaaagaaa atacattaga tgaatctaaa aattcagata
     5161 atgtaaattc taaaaaagat gatgtgtcag atgaaaaaaa tactgataac aaagttaaaa
     5221 aaagggaaat aaagctaaac aacaaaacac ttaaagctat tgtagcaatt gttgcagtag
     5281 gagctatatg tttaggtgga ggctatgttt ttggcaaaga agctggaaga aaattgcctg
     5341 ctacttcaaa acactataat agcagtgagg tagtagctac tattggggat aaaaaaataa
     5401 caggtgaaat gttaagaaag agaatggagc cattatttta tttaaatgca aaaactacta
     5461 tgactgatga cgaaatacgt tcatatgaat caaatatgat tgaaactatg attacatctg
     5521 atatattatc ctctgaagca gcaaaagaga aaataagtat aactaatgac caactagatg
     5581 ctcagtataa taatttaatg agtagtatag aatcagcaat gggaatgact aaagaagagt
     5641 ttttaaaaca gtttgatttg actgaaaaat atataaaaga tgatatgaaa aaagagctag
     5701 tagcatcaaa atatttaaat gaaaaatcaa aagttactga taaagaagca gagaactatt
     5761 acaataaaaa caagagcaat tatttacaag ttagagcttc acatatttta ataaaaactg
     5821 ttgatgataa aggtaagcaa gttagtagta gcaaaaaagc tgaacttaag aaagaagctg
     5881 aagaaatact taaaaaagcc caagctgggg aagattttgc tactctagct aaaaaatact
     5941 ctgaagatag tagtgcagaa tcaggtggag atttaggttt ctttggtaaa ggtcagatgg
     6001 tggaatcttt tgaaaaagca gcctttgcat tgaagaaggg agaggtatct aacaaacttg
     6061 tagaaagtga ttatggatat catataatta agaaaactga tgaaaaatat cagccatttg
     6121 aagaggtaaa atcagattta gtaagcagtt taacatcaga aaaacaaaac ctacttatac
     6181 aaaatctaaa agaaaaatat aatgttaaaa ttacagataa atatcaaatg aaagctaaag
     6241 aatagataaa gtcaatttat taaaaaaaag aaaaattaac tgtatggata aaagctattt
     6301 ttactcttaa tatagagagt ataaaatagc ttttattatt ttgcaataaa atctatttat
     6361 atatatgaag tgacaaagaa ataacatgca aaaagatatt aaaaagaaat atttttaatt
     6421 tgaatttttt caataaaaat ttacaaaaat gaaaaaacaa acaaaaaaga attgaagatt
     6481 taagttgtta tttaaatata tatatattaa gattttctgc tgaagatact aaaaaaataa
     6541 tatttttcat aattttaaaa ataataataa aaaaatgaaa atacaggcga taatctattg
     6601 agtaaacata gaaaagatga tattataagt atgtgctaaa atggttaaag caatattaat
     6661 attaaattta actataaaac aaaagggggc gtttttttat gtcaagtaca gaaagcgtat
     6721 ctaaaaaaag tggtcatccg aagagttttt ggcttatttg catgacaatt ttgtgggaaa
     6781 gatttagtta ttatggttta acagctttat tggtattatt ttttacagca agtgtagctc
     6841 aaggtggttt aggtctttct actcaagaag caacatccat gtttggctta tttacaggtc
     6901 ttatatatct tacaccatta gtcggtggct ggttagcaga taaagtttta ggtcaacaaa
     6961 aatgtatttc tataggtgca cttttaatag caataggaga tttcgtacta tttgcttcat
     7021 ctacatctat tgcaatggtt tgggtaggtc tatcaataat tattttagga aatggttttt
     7081 ttaaatcaag ttgctcaaat atagttgggg atatatatcc taaaactgat gtgtcaagaa
     7141 aagatgcagc atacagttta ttctatatgg cagtaaatgt aggagcattt atagctccaa
     7201 taatatgtgg attgctttct gataatgtat ttgcagtaag aggagcaagt ggagatatag
     7261 tatcttatgg atataagatg gcatttttaa tttgtggtat aggcatgatg ttaggtatga
     7321 ttatatttac acttcttgca ccaaaattat taaatgaagt cggaaaatat cctgtgacta
     7381 aaggtaataa aggtgaaaaa attgagtatg gaccacttac taagttggag aaaaatagga
     7441 taatagcaat ggttatttta tttttatttg tggtcttatt ctggacagca tactatcaaa
     7501 cacaaagttc ttttatgatt tatgtaaggg ataatgtaaa tagaactcta tttggatttg
     7561 aaatgccagt agcatggctt acatcactaa atgctatatt atgtgtggct ttatgcccag
     7621 tattagctac cctatgggtt aaattatctc ataccaaaag aggtgatttc tctattccag
     7681 ttaaaatggg attaggaatg ataataatgg gtgttgggtt tatagttatg gtatttgcta
     7741 cattagctaa tggtccagat ggaatggtaa aggctagtat attgtttata gtattgactt
     7801 atatatttac aacagtaggt gaattattct tatctcctat aggacttgca atgttcaata
     7861 aattagctcc agctaagtat gctacgttgt ctatgggagc ctggtatcta acaagttttt
     7921 ttgcaagttt attatcagga aagattgctg gttttacagc cacacttggt tttttacaga
     7981 tatttggagg aatagcaaca gttttaataa tatttggttt aatattattg ggaataagaa
     8041 atgtattaac aagattaatg gctatggatt tactaacaaa agaaaaataa ttcatgacga
     8101 attattgtaa ataaatgaat tactttaaat aaaggaagtt acatttaaat ataaaattaa
     8161 atgtaatttc ctctttgatt atgaaaaaaa gctttacaca aatagatatt ataattaaaa
     8221 ttataattgt gataattaga gtgtataaga tttatataaa ttatacaaaa aatatttatg
     8281 taataaactt tacatactta tatatttagt tattcaaact attatttcga ggaggtcttg
     8341 ttgtgaatat aaaagataga ttaagtggat taagaaaatt tatggaagaa aaaaatatag
     8401 atgcctatat gattccatct tctgataatc accaaagtga atatgtagga gattacttca
     8461 aatcaagaga atttatatca gggtttaatg gttcagcagg gacggttatt gtgactaaag
     8521 acgaagctgg gttatggaca gatggaagat attttataca ggcagaatct caattagaag
     8581 gaagtacaat aaaattattc aaaatgggac aagaaggttg cccaactaca gatgaatatt
     8641 tatataaaaa tattcctgaa ggaggaactt taggatttga tggtagagtt atatctgcta
     8701 gagaaggagc tacattagct gaaaaattat ctaaaaaagg tataaagata gaatatcagt
     8761 atgatttaat agatagtata tggccagata gacctgcttt atcagatagt aaagcatttt
     8821 tattagatgt taaatattgt ggagaaagtt ttagctcaaa attagctaga ttaagagaaa
     8881 aaatgagtga aaaaggtact tctactcatg taataactac tcttgatgat atagcatggt
     8941 tattcaatat aagaggtgga gatgttaaat ataatccagt tgtactttct tatgcagtaa
     9001 taactttaaa agaagtttat ctatttgttg atgaaagtaa gttaaatgaa gaaatactaa
     9061 atgaactagc taaggaaaat gttcaaataa agccatataa tgatgtgtat gaatttgtaa
     9121 aaaatataga caaaactgaa aaagttttat tagatggaac taagcttagt tatacaattt
     9181 acaataatat accttgtgaa gttgagaaag ttgatgagtt caatccagta atgtttttta
     9241 aagctcaaaa aaatgaggta gaattagaaa atataagaaa ttcacatgta aaagatggtg
     9301 tagctttcac taaatttatg tactggttaa agaaaaatgt aggtaagatg gaaatcactg
     9361 aaataagtgc tactcaaaaa ttagaggact taagaagaga gcaagaaggt ttctttgagc
     9421 caagtttcaa tacaattgct gcatataaag agcatgctgc aatgatgcac tatagtgcaa
     9481 ctccagagtc aaattataaa ttagaggcag aaggattatt tttagtagat tcaggtggac
     9541 aatattatga tggaactact gatataacta ggactacagt tttaggacct ataagtgatg
     9601 aattaaaact acactttact tctgtagcaa gaggaatgat aaatctttct aaggctaagt
     9661 tcttgcatgg ttgtagagga tataacttag acatactatc tagaagttgc atgtggaata
     9721 tgggaattga ttatcaatgt ggaactggac atggtatagg atttgtgcta aatgttcacg
     9781 aagctccaaa tggatttaga tggagagtag tacctgaaag atttgatagt gcagttcttg
     9841 aagaaggaat ggtaactact aatgaaccag gtatatatat agaaggttct catggtataa
     9901 gaacagagaa tgaaattgta gttagaaaag ctgaaaagaa tttctatggt caatttatgg
     9961 aatttgaagt tgttacgtta gctcctattg acttagatgg tatagtacca gaattaatga
    10021 ataaggatga aaaagattat ttaaactggt atcataagtt agtttatgat aaaatatcac
    10081 ctttcttaac tgatgaagaa agagaatggt taaaagttta cactagagct atatagtttg
    10141 tactagatac aataaaaatc gaggtattat aatgcctcga ttttttattg tatattttat
    10201 taactttaaa aaatttttaa tttgataatt ctactaattt tttattcatt ataagtagta
    10261 taattccaaa tatcaataaa aatgatggta tcactatgaa gacttgtaac ataccaagtt
    10321 ggtctataat agcttgcgta tagccagata atttatttgc tgcaaatttg cctaaaaacc
    10381 aaacacccat taggaatgaa atatactttt caggcgaaag tttatttacc ataccatacc
    10441 cgactggaga aaagcaaatt tctcctatac tttggaatgt taaaaatcca actacccaaa
    10501 atacacttgc tttgtgaatt gaattagggt ctgttcctgt ttgtataact gctactatca
    10561 taaacaaaaa tgctatggct aatagtataa aacctaagct catttttttt ggcacactta
    10621 aatcgccttt tttagtttga gataatttta cccatactaa agcagagata ggtccaagaa
    10681 taacacaaag gagaccattg tatgaatcta tccatgaagt aggaatttga aaattgccaa
    10741 cagtaagatt tatgtgttcc tttgtataga gtgcaataga catagaggct tggttatatg
    10801 ctatccaaaa aaatactgtg aaaaaagcta acaccaatat tactattatt ctttttttct
    10861 caatcaaagt taaaggtctt gaagctagca ttttcttata ttctagtgat tttcttatag
    10921 actctctccc gttactaggg tcattattca aaggtttata aaactttctg tttccaaata
    10981 taaagaagaa taaacctatt agaaccgtaa ttgatgaaaa taaaaataca tatctatatc
    11041 catacatact tatagataat ccgcttttca tagcaaacca ttcattagca actaaaccgc
    11101 atattaaagg gccaaataag gtacctagat tagtagccat atacgtaata gagaaagctc
    11161 catcttttct tgggtcatca ttggtatata agtttccaac catagtatgt aagtttcctt
    11221 tataaaaacc tattcctaat ccagataaaa atatcatgat gtttatatcc atcttactat
    11281 ttgctatgta tcctagaaaa taaccaattg aaaccattag cattccaagt ataatacagt
    11341 ttttgggacc taaaaatcta tcactgaccc atccaccaat aactggagag aaataagtcc
    11401 atgctaaaaa agatgcaagc attgatgcgg attctgctgg tgttaaccct aaaccacctt
    11461 tggagacttg ttcagctaaa aacaataata ataccaattt cataccatag tatgcaagtc
    11521 ctacaaaggt aaatattgaa cagcagaaat ataaatctct aggttgttta agtttttctt
    11581 gcgtttttaa aactgacata tgtcgagaac ctccagataa atagtttaac aaaattttac
    11641 catactatat gagtatatgt ttttttcata tagacgtcaa cttgtaagat aatttaatta
    11701 agtcgaaata tatgtaaaaa tagtatcatt tttgtgtatt cagtaatatt tttttatgat
    11761 aatatatgtt attattatat taaaatacaa acatatttat ggaaaggata tgccaattta
    11821 gtagttagat tgattgtttg gcaggtggga tgagctatga taagaaagaa atctgaatta
    11881 caagtagaag taaaagaaaa tttaaatggt ggtataggaa aggttaagct tgaaaacata
    11941 atacaaaatg aagagcttaa aggaaaagga agactattta aaagagtagc tttaccagta
    12001 ggaagttcaa ttggtgtgca tgaccataca acagattttg aagtatatta tatactaaag
    12061 ggaaaaggta aagtatttga taatggggaa tttgtagaag taaatgaggg tgatgtagtg
    12121 tatacagctg atggcgaaaa acattctata gaaaatatag gagaagaaga tcttgagttt
    12181 gtagcactag ttttatatat gtaaaatatg gaggaggagt catgacaggc aagatagaag
    12241 aaattaagga caagataaat agattttgca actccaattt aaatcaagaa tacaaagata
    12301 taagctttaa aattttgcaa aaccttttag ataataataa agagataatt cattcttcta
    12361 gagctgatat atggtcttca gctatactaa atatagtttt agaacaaaat cttttataca
    12421 ataagaagca tccactacat ataacaaaaa aagagttttc aaaacaaata ggtgtttctt
    12481 taaatactat aaataataaa tcgtctttaa taaaagatgt ttgtagtatt gactttttaa
    12541 atcaagatac tatagctatt tctaatgtag aattttgggt aaaagagacc aattccaaat
    12601 caaagtctgt agatttagat ttagaaaaga aaaaaatact atataaaaga tatattaagc
    12661 tatcacaaga tgcgaatagt gatattgaat caattagata tatggaggaa gctgtaaata
    12721 taggtaaaag tatgattact aaagaagata aagaacttgg attttggaaa ggtttatcta
    12781 ccagagccta tatgatagca cttgaatccc ttgctagaaa gttagaaagt attaataatc
    12841 taaaggagtc caaaaaagta ttagaatatt taatagaaat taatcctagt gatgagcagg
    12901 gaataagata caaattatta aatgtattaa ttagattaaa tgatagaact tcaataaata
    12961 aattatttga actttataaa gaagaaaaat ctgctacatg gatgtacagt aaagctcttt
    13021 attactttaa aaataaaagt atgtttttgg caaatgattc tattaaggtt gctagaagta
    13081 aaaataagta cgttggatta tatttgttag attggcgaaa tgcttttggt agagaatttg
    13141 ttacagagga agaaaaggca gaagctgtct attactatga tgaaaacata gtgatttgga
    13201 atgaagttaa aggttctatg gattggctat taaaaaaaat gttggaattt tcataaaaaa
    13261 aactactcct tacttttata taagtaaaag gagtagtttt taatttatac atctagtttt
    13321 aaatcttcag gttttattag accttttttt ctcataaatt ctgaaatcaa caaagttaca
    13381 atagcaggaa gtataaaatt aagtaaaagt ataccaaccc acatagatat acctcctttt
    13441 ccagcacttt gcatagcagt tactgttcca aattgtccaa ccaatccaca agtacccata
    13501 ccagaaccaa taggaatatt ctccattttg aatattgttg tagataatgg tccaagtaat
    13561 attgaagcta cagtaggtgg tatccaaatt ttccaatttt ttattatatt aggtacttgc
    13621 aacatagatg tcccaagacc ttgtgccaca aggccgccaa ctccattttc tctaaagctc
    13681 ataacagcaa agcctaccat ttggcaacaa caacctacag ttgctgcacc accagcaaga
    13741 ccacctaaac ttaacatcat acaaatagct gcactactta taggtaatgt aagagctatt
    13801 ccaacaagtg cagagactaa agctcccatt attataggtt gcatagttgt agcttgcatt
    13861 attatatttc caaatgaagt cataaaagca gaaacagctg gaccaataag ttcagctaca
    13921 agtactccaa ttagtattgt tacagcaggt gtaaccaata tatctatttt tgtttctttt
    13981 gaaactaatt ttccaacctc tacagcaaaa agtgtagcga caaatgctcc aacaggtcct
    14041 cctaattcat taccacaagc tccaacaagt gcacaagaaa atagtacaag tggaggtgct
    14101 tgaagtccat acgcaatagc cactgctata gctggaccag taacctgttt agcaagaggg
    14161 cttataactt cagtaaaaag agaaatattg aaattatctc ctaatgtatt gaaaattgtt
    14221 ccaattaaaa gggacgaaaa aagaccgagt gccatataac ttagtgcgtc aataagatac
    14281 ctttgaacag aaatttcaat attttttctt ttagcaaatg atttgaaatt tcttttttta
    14341 taattgattt ccaatttaaa atcctcctca tataatataa gtataatttc tttttaatta
    14401 attatataac ttttcagctg acaagacaaa tgttatttca ctaaaattag actattgtaa
    14461 tagtaagaaa ttaacattaa ttttagtttt aaattttaaa tttatggttt ataattagta
    14521 tagggatatt ctgaaatata ataattttcc agtttatccc aatatttaac ttaggtagat
    14581 tgcttacaaa acaaatgatt atatattagg ctaaaaggaa gtggatagat gatatttgta
    14641 aaaaataaga aatacagaaa aattgccata attatatcta ttcctatatt gcttgttgcg
    14701 cagtactacc tttttaaatt tggaatactt agaccaatgg taaagggagt agaaattgaa
    14761 attgtagatg gggaatatgt taaagatata gataaatatg tagtaaaatt aaatgaaaca
    14821 gttactttgt ctacaggtga atatattaag gttccttcgt atgctaaaaa tccaaatatt
    14881 tggtttaatg tattggataa ctcagggact ttaaaaatag atggaaataa aatgacagca
    14941 ttaaaggttg ggtattcttc tgtgggtatc atgaaaaatt caagagtatt aaaaaaggct
    15001 actataaaag tagtagaccc agaggtagaa tcactagata tggagattaa tggggattta
    15061 aaacatgttg gtgatagtgc tactatagaa agtacaatag aagttgatta tgataagttt
    15121 aaaaaatcat ataagccagt ttataagagt agcaatgaaa atattttaaa aatcaaagga
    15181 aataaagtaa gtgcagttgg agttggtaaa gctacaatat atgctaagtg tggaaataaa
    15241 gaaattgaga gaacatttag gattcaagct agagttgctg aaataaatat ggatgatata
    15301 aaaatagaag ttgaccagaa tgaaaaattg aaaccagata taataacttc tccacctggt
    15361 ttagaaccac caaaaatata ttatgagtta gtagattcaa aattacctgt agaaagagca
    15421 ataagtttaa gtagtaatgg aaatgttgta gggcttagag aaggtaaaga tagggtgaga
    15481 ataacttgtg gagataaatc taaagtaata acagtaacag tagtcaaaga aactataacg
    15541 aatgactata tacaaaactt ggttggttca cataaaatag taaacaataa agttattatt
    15601 aaacttgaat gggattatat gaaagatgtc tttgattatg atatatatct taaagataag
    15661 ttgtcaggag aatcatttaa gaaaattaaa tctataacta taaatgaaag tgatttaggt
    15721 aagtctaaca aggtatatgc aactatagaa gtagatatga agggtaatca aaatatagat
    15781 tttgatattt atgtcatagg taaaaaggat tcagatacaa ctaagccaag taatgtaata
    15841 aatattacca atggaaatgg aaattcaaat aatgataata atattaaaga tatgagggta
    15901 gaaaatatat cagctaatgt tgatagagat aataatgtca ttagagttaa ctggagtagt
    15961 atatctcata aggactgtac ttacagtata tatgtaaaaa ataatactaa tggagatgga
    16021 gaatttactc tatatcaaag tgatatacag ggaaatgagc atactataag tattcctgaa
    16081 ggagatttaa atctagatat ttatgttgtt gcaaattata atggaaatag ctctcaaaat
    16141 agtgatgtta taaatgtaag atagatttgt atacaaattg aaagtgttga gtttatttaa
    16201 atattaaatt aagaaaaagg atagtatagg gtaattatac tatccttttt tgttacaata
    16261 tataggttta aaatctctag taatataaat tataaaaagt cttatttaca caaatctata
    16321 gatatttttt ttattaatca atattgtctt aaattgaact tagtgcggct tctattgcat
    16381 gtattactgt cgtatcaaat agtggaatag aagtgtcatt ttgtttaatt aaaagaccta
    16441 tttctgtaca tcctaatata acagcctctg caccttgttt gccaagctta tctataatag
    16501 ataagaaagc tttttttgaa gattcagata taattcctaa gcaaagttca ttaaatattg
    16561 tgtcatttac tattatacgg tcttcttcat ttggaattaa gacttcaatt ccattattaa
    16621 taattacatt tttataaaaa tcttgttcca ttgtatattt agtacctaat aaggccactt
    16681 tttttatttc tttttccctt aataccgtag cagttacatc tgctatgtga agtaatggaa
    16741 tatgtatact ttcttgtatt ttatctgata ccttatgcat agtattagta cagataacaa
    16801 taaaatctgc ccctgcctct tgtaatttaa ttgcagcatc agctaaaatt ttggcgcttt
    16861 tttcccaatt tccactagat tggcattctt caatttcttg aaaatctaca ctgtaaagta
    16921 tacatttaga agagtgtagt ccacctaatc tttcttttat tactgtatta ataacttgat
    16981 aatatgtaat ggtactttcc caactcatac caccaattaa gcctatagtc ttcatattat
    17041 acctctctta tttatttatt ttgaaatagc tatttacaaa tacaagtata gcatctaaaa
    17101 tagaagcata caataataaa attgtatgga gtacaattat aattaagagg agtaattata
    17161 tgccaataaa ttcttttgaa aactatccta tgacatggaa accaaagtta gataaccgaa
    17221 aaccaccaat atataaaact ttagcaatgt tattagaaga agatattaaa agaggaaatt
    17281 taaatcctgg agataaattg cctccacaac gggaattagc agattttcta gatttaaact
    17341 taagtacaat aacacgagca tttaaacttt gcgaagaaaa gggactaata tgtgcaaaag
    17401 tgggaaaggg aacattcatt tcttctgatg taaatgtaag taatacatta ttatatcaaa
    17461 cggaatcaaa agacataatt gagttgggga cagttcatcc tccgtatgag caaaatacat
    17521 atattattga ctttattaaa aatgtactaa aacaaccaga aatggatagg tttttacaat
    17581 acatgtctcc atctggcaca tatatgcaaa aaaagtcaat tgcaaaatgg atagaaagaa
    17641 ataatgtata caccagtgaa gaaaatatat tattatctac aggagggcaa aatgctatat
    17701 gtgcaacttt actaggatta tttaaagctg gtgatagaat tgctacagat tctttaagtt
    17761 tttctggaat taagtcaata gctaaaatga taggtattca attagtccca attcctcaag
    17821 aaaataatga aatatcgatt gaatatcttg aaagttattg taaaaatgaa aatataaaag
    17881 gcatatatct tataccagat tatcataatc caacgacaca tactatgtct gatttatctc
    17941 gtaaaaagat agccaagata gcaaagcaat ataatataat aattattgaa gatgctataa
    18001 atagcatttt tagagatggt atacaaactc ccatattttc tttagctagt gataatacta
    18061 tatatatttt tagtacatct aaatttttat gtgctggtct tagagtagca tttgtagttg
    18121 ctccaaaacg atatatagaa aatttagaaa atgcactata taatatgaat ctaatggttt
    18181 ctccatttac agcagaaata gtacaccgtt tattatattc tcctattata gataaaatta
    18241 tagaagagaa aagagatgca attatagaaa gaaatgaagt tgctgataaa gttttgtcag
    18301 attataattt gattggtgat aagaattgca gttttcgttg gttacttctt cctgatgaat
    18361 tggatggaaa atcatttgaa atttctgcaa aaaatctagg agttcaagta tattgtgccg
    18421 aacgattttc agtaggaaac tctacagttc caaaagcagt tcgtatttgt gtaacagctc
    18481 caaaagatgt agaagaatta gaaaaagggc ttaatataat aaagtcactt cttaagagtt
    18541 aaatttattt tactattatt taattaaata aataaaaagg cggagaaatt tattataata
    18601 aacctccgct tttattattt aatgaaatac tttacttttt attaaaaaat ttaattttaa
    18661 taatcttgaa aatataatcg ttttatggta aaataattct taaaaataga aaaaattaat
    18721 catttgttaa aaaaaatgca taatttattg taatttattg acgaaggttg aaaaatattc
    18781 ataaatgtgc gaaataacag aaaaaatgca aaaattaatt caatttcatt tgttataaaa
    18841 tctatatggc aaaattaaat ctgcctatca gaatgatata aacacatcag aaaggaggac
    18901 gctatcaaat aatacaagta gttaactttg atagcaaaaa attatgaatg aacaaactag
    18961 aatatcctta gagagagctg ctgaattaaa atcaaaaatt gatgattata ttcaggctag
    19021 aaaaacgatt aacagaggtc ttgaaaaaga agaagagata aataaacgaa aacagaaaat
    19081 attaagtatc ttaaatggaa ctgaagagga ttggaataac tacaaatggc aattatcaaa
    19141 tagaataaca gatgtagata ctttatcaaa aattataact ctaactaaaa aagaaaaaga
    19201 atatataaaa gaggttggta ctcaatttag atgggcaata tctccatatt atttgagtct
    19261 tatagaccca gaagatatat gtgacccaat aaaattactg tctataccaa cacatataga
    19321 gttggaagat gagcaagaag atttggaccc aatgggagaa gagtatacaa acccagcagg
    19381 atgtataact agaagatacc cggatagatt aataataaat gtaacaaatg agtgtgctat
    19441 gtattgtaga cactgtcaga gaagaagaaa tattggacaa caagattctc ataagtcaaa
    19501 agctattatc caagaatcta tagactatat cagagaaaat gaagaaataa gagatgtact
    19561 agtaactggt ggagatgctc ttacattaaa agatgattat ttagagtgga ttcttagcca
    19621 acttaaagag ataccacatg ttgattatgt tagattaggt actaggactc ttgttacaat
    19681 gccacaaaga attacagatg aattttgcaa tatgctaaaa aaatatcacc ctgtatatat
    19741 aaatactcat tttaatcatc caatggaaat aactaaggaa tctaaagaag cttgtgaaaa
    19801 gttagcaaat gcaggcgttc cattaggaaa tcaggcagta ttattaaatg gaataaataa
    19861 tgataaattt gtaatgagat gtttaaatca agaattactg aaaataagag taaaacctta
    19921 ttatatattc caaagtaaac atgtaaaggg aacaaaacat ttcaatacat cagtagatga
    19981 tggtcttgaa atcatggagt atttaagagg atatacatca ggaatggcta taccaacata
    20041 tatagtaaat gctccaaaag gaggaggaaa gactcctttg cttcctcaat accttgtatc
    20101 aaaaggaaca gattacgtta tgcttagaac atgggaagga aaagttataa aaatggaaga
    20161 tgaacctgct gtagatataa agaaacttat aaaagaacaa gcacaggatt aaaaaaatat
    20221 ttaaagttta taaaaagaaa caactttaaa ataaaaagaa aatggatgtc aaatttatat
    20281 caatttgcat ccatttttta ttagttattt attattttgt tgttgattaa ctaattcaag
    20341 atatccactt gggtggaagt aatatatctc agaagtattt tcatttacaa agtaaccaat
    20401 atcaccatct gcatctggta aaaatacata accattaaga tttttagctt ttaatgcttc
    20461 aaaatcacta gcatttcctt gatatatgta atcaacttca ttgttgtatt ttactaaaag
    20521 ttctttagct tgttcttgag tcaatttagt attttggctt acaggaacat tcttttgaga
    20581 atctgcataa gaagattcat ttactggtgc agttaataac aaacaagata aaactaataa
    20641 agatataagt gcttttttca tactaaaacc ctctttcatg tttaattata taagattcat
    20701 tacttaataa tattgtatgt ttcctataat taaatattac cattaaagag aataatatta
    20761 cagttacaca gctgtaactt ttgattacaa aatcgtaatt aaattgtatt tttattccat
    20821 ttgtatttta tcatgtctac gatttacaaa ctcacagaag tatatcttta taacgcccat
    20881 cacaggagca gatagaatca taccaggtat accaaagaat cctccaccaa cagtaactgc
    20941 taggattgta aagaatgggc taagacctag ttgtccacct acgatttttg gctctataaa
    21001 tgtaacttca acttgttgaa ttattattaa gtaaattaaa gaagttaaag caattgttgg
    21061 attggagaat aaattaatta ttacaactgg tgccatacct attactggac caaaatatgg
    21121 aaccatattc atgacaccca taagtgtacc aaataatagt gcatattcag attttaaaaa
    21181 gtaaagacca attccagaaa gtactccaac tataaaagaa tctaaaatct tacctgtaaa
    21241 gtatttacca atatttaaat ttaagctttg acatagttct attataaagt ctccatattt
    21301 tttacctaag gaaatataaa ctactttttt tgtaaacagt aagaattttt ctttttctaa
    21361 taatatatag aaacaaatta taaaacctaa aagaaattgt actataaatt ttccaactga
    21421 aaatgtagtg ctaaatatcc caccaagtga accaataagc aagttactaa atttaggcat
    21481 tacactcata attttgtcac catactcttt taatgtatta gggtcaactg attgtaaact
    21541 cttgcctaag tcgaataaaa actgctctgt tttatctatg tatgtaggaa tttgagcaac
    21601 taaatcagct aaactattta ctatggatgg aactgtaaat aatataaacg aaattagtat
    21661 aactatgagt acaccataag taagaagtaa cgaatatatt ctcttaaaat ttaatttact
    21721 ttctaagaac tttactagtg ggttgaatat atatgctaat acaaatgcta ttataaatgg
    21781 tgttagtagt gacattaata aacttatcac tccaaaaaaa tatttgtaat tatcaataac
    21841 tttaatcaag atatatgaaa caactacagt gagtacaata tttagataaa tttttttatc
    21901 ttgcaaaata acacaacctt tcttatattt attaaattta gatatactta aatctaagtt
    21961 aaagttaata tttatagctt attatacaat aaaaagcagt attaatatag tatgattaat
    22021 atgaaattat aaatacgtta aaactttatg tttatagcta aaataataaa aattatttat
    22081 attgtgttta tatataatct aaaatgaaaa aaagtggtgc ctttgattaa actagtttt
//
LOCUS       DAEPID010000066        22038 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.066, whole genome shotgun sequence.
ACCESSION   DAEPID010000066 DAEPID010000000
VERSION     DAEPID010000066.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 22038)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 22038)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..22038
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.066"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            12..719
                     /locus_tag="KR257_002791"
     CDS             12..719
                     /locus_tag="KR257_002791"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018592356.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBH0031471.1"
                     /translation="MKGFKTNVLKNISLTVNEGDFISIMGPSGAGKTTLLNLMSTLDK
                     QTSGEIILDGINISKVKNNELSKLRREKIGFIFQDYNLLDNMKLMDNIALPLALGKKK
                     SKEIEAKVFSIAKKFGLENHLDKYPYQLSGGQKQRGAAARSLITNPTVIFADEPTGAL
                     DSKSAYELLESLEKINRENNATIIMITHDPLTASYSNEVYMINDGNIKCKLNKGNSRK
                     EFYGKIMDMLASMGGEM"
     gene            720..2627
                     /locus_tag="KR257_002792"
     CDS             720..2627
                     /locus_tag="KR257_002792"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891367.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="FtsX-like permease family protein"
                     /protein_id="HBH0031472.1"
                     /translation="MSILGIAYNNFKSNIRTYLAFFISMVFSVVVLTNFELLRYGDAI
                     NVLQEENKKFTLSVLVAVIMILSVFLFFFIWYATNIFFKNRSKEIGILSFMGLDLYTI
                     GKIYFVENMLIGISSCITGIIIGIITSRFFQVVIIKLSGFNIKVSNGLSIEAILYATL
                     IFISIFIIMAVKGFITICRSSVINLINISKKQEKIPKVGIGIYILAIVSIIVIGYGYY
                     LSTNIRTGDITSVLPVIGIIIVGTYGLFKSVMPVIFDIIIKNKKILFNGNNIIAINNI
                     NYRLNKNYKTYAIIAIIITTTISTLGASVAMKHIHKNAQEQRNVYTISIVSMDKDEVN
                     KKQIENIIKDTNKIKYSVNPELTILKKTDIKEAYDTTDTIMKYSDFCNTLKVNGNDKE
                     LKEYGERLVSGNNVIELKSPQTIASIATKEAKIKLDGQLYNISRGEVKVPVLGTGLNQ
                     SIIVVNDDTYFKLRDKGQQVYFYGAKVFQEENSQVMFNNIEKNLSLKNGYIQNGYKAQ
                     GESQWMKFAYVVLVFLFLVFAIVAGSIIYMKIYSDAYEDKEKYKILLKIGTTEKDINR
                     AILKEVAIFYTLPMLSATISSYFALRLAGDLLMTDLFGIYILSLVICLIIFIIYGAVS
                     VNKFKSVVYKN"
     gene            2779..3459
                     /locus_tag="KR257_002793"
     CDS             2779..3459
                     /locus_tag="KR257_002793"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898117.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HBH0031473.1"
                     /translation="MYRILLVEDDIDLSKEIALALEKWGFKVELIDDFEVVLDEFIDK
                     KPDVVLLDVNLPLYNGFYWCEKIRAISNVPLIFLSSRDSDMDLIMGINNGADDYITKP
                     FSIEILVTKINGIIRRVYNYSDSNSILYCEDLMFDVGKGIIKHKYKDKSIELTKNEIK
                     ILTLLLKNKNRVVSRESLMMTLWDNDEFVTDNALTVNMNRLRSKVKELGFDDFIKTKK
                     GIGYIIQC"
     gene            3453..4472
                     /locus_tag="KR257_002794"
     CDS             3453..4472
                     /locus_tag="KR257_002794"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003431379.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HAMP domain-containing histidine kinase"
                     /protein_id="HBH0031474.1"
                     /translation="MLVKYLKGRSKYIALPLVVVSIINIYLFAIDIFKNKYSELIYLD
                     FLVLFIIMVFFVIDYINFRNSYTNLYNCIENSGEIDSYLVDGQSFEENLIKDIIENLK
                     IKNNSDIETYKQSLKELDEYIAKWVHEIKIPISSLSIITDRLSSIEDSLDIKNQVAKI
                     NFLVNSILYSSRSNTMFEDVFINKFNLEKLVKMSIKNNSFLLIKNNVEVSLNELENDV
                     YTDSKCMSYVLDQIINNAIKYSKEVGKIEFNSKKLENGVVLSIKDFGIGINEEDISRV
                     FDKGFTGKNGRNQLYKSTGMGMYFVKKMIDSLGHEIEVCSKIGSYTIFNIYFYDISDY
                     LSIDS"
     gene            4903..6063
                     /locus_tag="KR257_002795"
     CDS             4903..6063
                     /locus_tag="KR257_002795"
                     /EC_number="2.7.1.170"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891364.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="anhydro-N-acetylmuramic acid kinase"
                     /protein_id="HBH0031475.1"
                     /translation="MITMYSVGLMSGTSLDGVDAVLAEISGNGRNTKVKQIEFITLEI
                     PKDIKDEIRKCCIEEESSVDLICSLNFKLGYLFSKAVKSVCHKANFHIANLDFIASHG
                     QTIFHIPRSYNNFVSSTLQIGEPAVIAYETNTKVISNFRVMDIAAGGEGAPLVPYSEF
                     LLYSDNNKNLALQNIGGIGNITIIPKSCNIDDVFAFDTGPGNMIIDGVCQRLFNRKYD
                     KNGYFASKGKINEEMLKDLMSHKYLSQAPPKSTGREVFGQVYLDNMLNKYKHVDKYDL
                     IATVTMFTAKAIYYNYKNFILPKVNVDTLLIGGGGAHNLTLIGYIKELLLEVEVLTQD
                     EYGYSSDAKEALAFVILGNETLNNSFSNVISATGAKNKVILGNITPKPFGGK"
     gene            6065..6463
                     /locus_tag="KR257_002796"
     CDS             6065..6463
                     /locus_tag="KR257_002796"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422533.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0031476.1"
                     /translation="MSNNKKKKRKKNNNYKNAKSTKSNKNTKKQMEKNQRTDYNIPTI
                     SFKSGLILIVSSLVSTVVFPLLLSIFGIDNRFGVVIGNSLITSFAVAYTRYFVETKRG
                     FSLGFFRLYILFALSFAIIGYFWIYKGIHI"
     gene            6725..7033
                     /locus_tag="KR257_002797"
     CDS             6725..7033
                     /locus_tag="KR257_002797"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891360.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIB"
                     /protein_id="HBH0031477.1"
                     /translation="MRVLFVCSSGMSSAIAVNALQKEGAKNGIDIDVLAVGTQEFENE
                     VKNGWDIAMVAPQVRHRFDYLKAFADEVSVPCALIQAQAYSPLGGPKLLKQVQELLSK
                     "
     gene            7122..8468
                     /locus_tag="KR257_002798"
     CDS             7122..8468
                     /locus_tag="KR257_002798"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003431385.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIC"
                     /protein_id="HBH0031478.1"
                     /translation="MLDKFTEFLDTKLSTSMARLAEQRHLRAVRDGIVASLPLIIVGS
                     FFLILAFPPLPDSWGVTQYLKENAVTILLPYRMTFFIISVYSTFGIGYSLAKSYKLDG
                     LTGGLLATATFLLTIVPTAIEGLTPELLKIVEKSPELLAWYNSIPQGWQMPMANLGGG
                     SMFVAIVTSIIGVEIYRFTDKSKFKITMPEAVPASVTRSFEALTPAALIIILMAIVTY
                     FLGFDWHGFIAKLVTPLVSATDTLPSVIILIFLITFFWSFGIHGVSIIGSLARPLWIQ
                     LLDANTASYAAGQAVPGIAAEPFFQWFIWIGGSGATIGLALLLAFRAKSAYGKSLGKA
                     TVIPAIFNINEPIIFGAPIVLNPILIIPFVVAPIVMATVSWFAMSANLVSRVVVTAPW
                     TLPGPVGAYLATGGDWRASVLNLLCIAISIIIYYPFVKMYDKRLLHEEKVEEQEAY"
     gene            8701..9798
                     /locus_tag="KR257_002799"
     CDS             8701..9798
                     /locus_tag="KR257_002799"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898112.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF871 domain-containing protein"
                     /protein_id="HBH0031479.1"
                     /translation="MGRLGISIYPEKTTSKEIYDYIDKAAENGFTRIFSCLLSVKDTK
                     ENIIKKFKRINEYAKFKGFEVILDVNPRVFGELEISYKDLTFFKKTKADGIRLDIGFT
                     GSEEALMTFNPQNLKIEINMSNNTNYIDTIMDYQPNKENLTGCHNFYPHRYSGLNLEH
                     FIKCTERFNKYGLRTAVFVTSQNETTFGPWPVTDGLPTIEMHRNLPIDIQVKHIIAMN
                     NINDIIISNCYPTYEELKVLGSMRKDMVTFDVAIEENIREVEKKILFEEIHFNRGDIS
                     DSLIRSTQSRVKYKGYKFELFNTPKIIKRGDIVIESSEYGHYAGELQIALTDMKNSGK
                     SNVVGYIRKEELFILDYIKPWQKFNFKPSTK"
     gene            9897..10811
                     /gene="murQ"
                     /locus_tag="KR257_002800"
     CDS             9897..10811
                     /gene="murQ"
                     /locus_tag="KR257_002800"
                     /EC_number="4.2.1.126"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891358.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="N-acetylmuramic acid 6-phosphate etherase"
                     /protein_id="HBH0031480.1"
                     /translation="MLIKTLENLVTEGRNKNTLQIDKEDTLGIIELINNEDKTVAYAV
                     EEQKESIAKAVNIIVDRMKQGGRLFYIGAGTSGRIGILDATECPPTYGVDFELVQAII
                     AGGNQAIFKAIEGAEDDKELGKQDIIDRGVTSKDVICGIAASGRTPYVIGAMEYAKEL
                     GCAVLSITMNPNSEMSKKADLPINIIVGAEVIMGSTRMKSGTAQKMVCNMLTTASMVK
                     MGKVYSNLMVDVKTSNEKLVERAKRIIMIATNVKYDVAEKFLEEADNSVKLAIFMIKS
                     GLDKDSAKSILDRQEGYISEALKSIEKL"
     gene            10921..11841
                     /locus_tag="KR257_002801"
     CDS             10921..11841
                     /locus_tag="KR257_002801"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891357.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="acyl-CoA reductase"
                     /protein_id="HBH0031481.1"
                     /translation="MYFLGVDGGGTKTTFTLVDEELNIVGTITKGTCHYNQIGFDNLT
                     KLLITGLEEVCKDAKINVEEITYAFVGLAGYGKIKEVLYALEVATKNAYSHINYTLGN
                     DVEIALAGSLNGEKGINIIAGTGSIAQALDKDGNLHRCGGWGYVLGDEGSAYYIGMAT
                     LKMFTMQSDGRCSKTKLYDLIKRHLNIENDYDIIKYVNDEIQGDRIEIAKFATICLKA
                     VIEGDNTASKIFDDAAYELSRLIIGLEHHFEQGTKIKVSYSGGVFKSGDLILEPLKKY
                     LNKTRFGIVRPVLTPDLGACLLAKKKYYSK"
     gene            11858..12709
                     /locus_tag="KR257_002802"
     CDS             11858..12709
                     /locus_tag="KR257_002802"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003439904.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MurR/RpiR family transcriptional regulator"
                     /protein_id="HBH0031482.1"
                     /translation="MSCILKLKQIYEDLTEVDKKIADYILNNTEAISKLSVSELASNS
                     KTSTASIVRFSRKMGYSGFGDLKIEIAKDLMGKENEYTYVDENYDCNIDSVINKITNK
                     NIETINQTRLLNEKDIIKEAVEQIIKAKNVYIFGVGGSALVALDLQMKLLRINKQAFT
                     SLDSHTQLMVSSNVDKEDIAIAISYSGESKEVIKSIENAKLKGCKVICITKYSDNHLS
                     KISDLKLVVPNIEKRLREGAISSRIAMLTLIDIIYISIIQENLNEAEQKLQETKRILD
                     YLNINNA"
     gene            13321..14382
                     /locus_tag="KR257_002803"
     CDS             13321..14382
                     /locus_tag="KR257_002803"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861792.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transglutaminase domain-containing protein"
                     /protein_id="HBH0031483.1"
                     /translation="MKKIRKLTTKLLITTIVLISGMSMTVYGMTAKEVTAKTPKSYVT
                     GTNSVYGPKLSQAQLNSVAQATADFMNKKITKNMTTDAKILVAYNHIKNNTTYVDWNA
                     VEGANTAYTLVTKKGACSGMARSMKALCDAMGIESYYVHSTSNDHQWNLIRFGDGRLY
                     HVDIDANKSAGKDIIYKSLSHPLPFDKTAYPKVGAIVQTVKPEQTQKPAPPGKHTMLP
                     HQEGAKAVGNFGKKGEDINEKHVMYEGVRCSVVNSSVNTITFTGSESNLDPSNLTIAV
                     IGFMNTPYGMFALAPEGKPVEYPFKYDKPFSLDFSGKNRSGAELAKYCKKNDVTIKIE
                     ITDEKANIGLGQIMYVRYE"
     gene            complement(14498..15472)
                     /locus_tag="KR257_002804"
     CDS             complement(14498..15472)
                     /locus_tag="KR257_002804"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009906205.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0031484.1"
                     /translation="MNNINSLKVIKLSLGCSLAIFIAWLLKLEYSMVAGVIVLLTVKD
                     TKRETLKGSIGKIYGFLLCTIFSYLCFNILGYNLTSFSIFIFIIIPLCFLLNIQDVIA
                     MCVVIASHYYLQGETSIKWILNEAGIFAVGTGIGVLINMYIPTNIHKIHEVQKKLQEE
                     VSIVLIDIADIIVNPKKENGYSRDLYTLNSLIDSSISETYDNINNTLLSDTRFFLEHM
                     DIIKSQRDILENLYSYVSQLNSTPPQAHILSAFIHKIGYTEFEAETGNLLLEELKRLM
                     LSMKNQPLPVDRTEFENRAILFLCLTELKQFLVNRKHAQILRDNNFYK"
     gene            15928..16809
                     /locus_tag="KR257_002805"
     CDS             15928..16809
                     /locus_tag="KR257_002805"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729000.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="proline iminopeptidase-family hydrolase"
                     /protein_id="HBH0031485.1"
                     /translation="MKITEGYMPFKGFKTYYRIVGENTEGKKPLVLLHGGPGSTHNYF
                     EVLDKIAESGRQVIMYDQIGCGNSFVEGHPELFNADTWIEELIELRKHLGLDEIHLLG
                     QSWGGMQAIWYAIEYKPKGIKSYILSSTLSSAKLWEKEQKRRISYMSEVDQKALLDAV
                     NTGDYSSKEYNDALERFMEMYCAGEVTEDSPECLRRPKKSGSEAYIVGWGQNEFSPTG
                     TLSGYEFTDRLHEIKEPCLVTSGAIDLCSPYIAKTMYDRIPNSKWELFEYSRHMPFVE
                     ENEKYIKVLTEWLNAND"
     gene            17191..17994
                     /locus_tag="KR257_002806"
     CDS             17191..17994
                     /locus_tag="KR257_002806"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003432058.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0031486.1"
                     /translation="MEKLRVIEMIKNNPNIIATIDNPTDEMKLLAIKENGLVLEYINN
                     PTREMQELAIDNNIRAIKFIDNPTEDMMIKAVNEGWSILDYIKNPTDKVIEMAINQAG
                     WAIKYAKNPSEELQLLAVRKNYDSIKFIKQPYESVQEEAVRISYDALRYIDSPSYNAE
                     LIAIKNNEAAISFITDLDKNKMLEFLKVNILVIKYILKKVSKDELESVLKEVLSKEDV
                     EEKYIRDFLNCSVIDRNSESIPIDKIMFIYKYGSKTAKKIAVDEKLKIM"
     gene            18006..19136
                     /locus_tag="KR257_002807"
     CDS             18006..19136
                     /locus_tag="KR257_002807"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422548.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding protein"
                     /protein_id="HBH0031487.1"
                     /translation="MNFIDTLKSVDLILSTGEVPLIVGESGIGKTALANKLAKENDWS
                     LIVIDGNLLKEGEIGGLPTIESYVGVNSNGYKTEKKTTVYAVHNKLREIDEEISKSKT
                     VLLFIDEINRCEHTVQQELMNLILNREINGYKLHDDVKILAAMNPSSKYGSDFDYQVV
                     DMDAAQENRFVWLNMESDHTQWIKWAIDEGIERKVIEFISTFPEYLHKINEDDVRATP
                     RSYERVSKIYKVYKEKNNSIPRAVFLNVVKGNVGKVIAEEFISFIESNSEPLISYEDV
                     FLGESIDESIVERVKNESHTRLYLSAMNILKDLELNIKNDKYESNHYINRFIEFLKMY
                     PVDLMIGIMKDIRNSYIEVYKKAIENEEFVKSYFESYSLIRG"
     gene            19140..20549
                     /locus_tag="KR257_002808"
     CDS             19140..20549
                     /locus_tag="KR257_002808"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903420.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0031488.1"
                     /translation="MENYFDKQAKELYNKASEIINTHSMLKANRANEKFDIDIPQDFK
                     YEFFSLVDKVNLSLMEEEDNFYGYFLFQMSREIRFDISSPTGVNFKGAKYVIYFNPII
                     FLTLDIKQMETTIKHEIHHILSMHLMRAKELKGKYSTLAINMAMDIVVNKFLNNLPPY
                     ATTLEWVNLKYSLKLEPYEPFEYYVEKIQTELDLMEVDEDGEEDDSDKYGDIEIDYSP
                     ERTHDIWDESNEIDENTLREFTEKFINSSQKGKVPAYLESMISSLKNSKGELPWNLYL
                     NRIMGTVENNKKKTITRRNRRQPNRLDLRGELRSHKSEIAVALDVSGSISDEEFKQAI
                     KEVLSIVKNYNHEITIIECDNEIRRVYKVRTEKDIKDRIRIGGGTRFSPVFEYANNKK
                     INLLVYFTDGKGENKLQVIPRGYKILWVISGRGDKISLKEPYGAVKKLTKVKTNDEIL
                     EINDVRNDGYSMNSQAPIL"
     gene            20760..21269
                     /locus_tag="KR257_002809"
     CDS             20760..21269
                     /locus_tag="KR257_002809"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422552.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CarD family transcriptional regulator"
                     /protein_id="HBH0031489.1"
                     /translation="MVMFLFKIDDYIMYGMTGVCKVMDITNERFTNGIKKEYYVLSPI
                     YSNNTVIKIPVDNEKVPMRKLLSKINVLSLINDIPNMDTSWIDNEKLRSEQFKKILRG
                     GKCEELIKLVRSIDNNREYVKSIGKKTHQADDNIMKEAERLLNEEFATILDISPNEVS
                     SYISSHIPQ"
BASE COUNT         8858 a         2209 c         3837 g         7134 t
ORIGIN      
        1 aagattatgg aataaaagga tttaaaacaa atgtattaaa aaatatatct cttacagtca
       61 atgaaggtga ttttatatca ataatgggtc catctggtgc aggaaagaca acattgctaa
      121 atttaatgtc tacacttgac aaacaaactt caggagaaat aatactagat ggaattaata
      181 tatcaaaagt aaaaaataat gaactatcaa aattaagaag agaaaaaata gggtttatat
      241 ttcaagacta taatctatta gacaatatga aactaatgga caatatagca cttcctctag
      301 cattaggaaa aaagaaaagt aaggagatag aagctaaggt attttctata gctaaaaaat
      361 ttggattaga aaatcattta gataaatatc catatcagtt atcaggagga caaaaacaaa
      421 gaggcgcagc agctaggtca ttaattacaa atccaacagt catatttgct gatgagccaa
      481 ctggtgcttt agactctaaa tcagcatatg aacttttaga atcattagaa aaaataaaca
      541 gagaaaataa cgctactatt ataatgatta cacatgaccc tctaacagca agttattcaa
      601 atgaagtata tatgataaat gatggaaata taaagtgtaa attaaacaaa ggaaatagta
      661 gaaaagaatt ttatggaaaa attatggata tgctagcctc tatgggaggt gagatgtaag
      721 tgagtatact tggaattgct tataataatt ttaagagtaa cataagaact tatctagcat
      781 tttttatatc tatggttttt tcagtagttg tgctaactaa ttttgaatta ttaagatatg
      841 gtgatgctat aaatgtgtta caagaggaaa ataaaaaatt tacactatca gtgttagtag
      901 ctgtaataat gatactatca gtatttttat ttttctttat atggtatgca acaaatatat
      961 tttttaagaa taggtctaaa gaaattggaa tattgtcttt tatgggatta gatttatata
     1021 ctataggaaa aatatatttt gtagaaaata tgcttatagg aataagttct tgtataacag
     1081 gaataattat agggataata acatctagat tttttcaagt agtgataata aagttatctg
     1141 gatttaatat aaaggtatct aatggactta gtatagaagc tatactatat gctactttaa
     1201 tctttatttc tatatttata ataatggctg taaaaggttt tataacaata tgtagaagta
     1261 gtgtaataaa tctaatcaat atatctaaaa aacaagaaaa aataccaaag gtaggaatag
     1321 gtatatatat attagctata gtatcaatta tagtaatagg atatggctac tatctttcta
     1381 ccaatataag aactggagat ataactagtg tactacctgt tataggtata ataatagtag
     1441 gtacttatgg attattcaaa tcagttatgc ctgttatatt tgatattata atcaaaaata
     1501 aaaaaatatt atttaatgga aataatataa ttgcaataaa caatataaac taccgattaa
     1561 ataaaaacta taaaacttat gctataatag ctataattat aactacaaca atatcaactc
     1621 ttggtgcttc agttgctatg aagcatatac ataagaatgc ccaagaacaa agaaatgtgt
     1681 acactattag catagtttca atggataaag atgaagtgaa taaaaaacaa atagagaata
     1741 taataaaaga tactaataag ataaagtact cagtaaatcc agaactaaca attttaaaga
     1801 aaacagatat aaaagaagct tatgatacaa cagatactat aatgaaatat agtgattttt
     1861 gtaatactct taaagtgaat ggtaatgata aagaattaaa agagtatggt gaaagattag
     1921 ttagtggaaa taatgtaata gagttaaaaa gccctcaaac gatagcatca atagctacaa
     1981 aagaagccaa gataaaactt gatggtcagt tatataatat ttcaagggga gaagtaaaag
     2041 ttccagtact agggacagga cttaatcaaa gtattatagt ggtaaatgat gatacatatt
     2101 ttaaactaag agataagggt caacaagtgt atttttatgg tgcaaaggta tttcaagaag
     2161 aaaatagtca agtaatgttc aacaatattg aaaagaattt aagtttaaaa aatgggtata
     2221 ttcaaaatgg atataaagct caaggtgaga gtcaatggat gaagtttgca tatgtagtgc
     2281 ttgtgttttt attcttagtc tttgcaattg tagctggaag tataatatat atgaaaatat
     2341 atagtgatgc atatgaagat aaagagaaat ataagatttt gttaaaaata ggtactacag
     2401 aaaaagatat aaatagagct atacttaaag aagtagctat tttttatact ttgccaatgt
     2461 taagtgcaac tatatctagt tattttgcat tgagattagc aggagattta ttgatgaccg
     2521 atttatttgg tatatatata ctaagtttag tgatatgttt gataatattc ataatatatg
     2581 gagcagtatc tgttaataag tttaagagtg tagtgtataa aaattagttg atatattaat
     2641 aaagagaaag gagattcttg taataagagt ctccttgttg attaactaaa taatttgggt
     2701 aataaattca tataaaatat gttatgatat taataattca tagcatagtg aaatattagg
     2761 ataatggaga atatacaaat gtatagaatt ttattagtag aggacgatat tgatttatca
     2821 aaagagattg cgttagcact tgaaaaatgg ggatttaaag tagaattaat tgatgatttt
     2881 gaggtagtat tagatgaatt tatagataaa aaaccagatg tagtactttt agatgtaaat
     2941 ttaccattat ataatggatt ttactggtgc gaaaaaataa gagctatttc aaatgtacca
     3001 ttaatatttt tatcatcaag agattctgat atggatttaa taatgggcat aaataatgga
     3061 gcagatgatt acattaccaa accattttct atagaaatat tggttaccaa aataaatggt
     3121 ataataagaa gagtctataa ttatagtgat tctaatagta ttttgtattg tgaagatttg
     3181 atgtttgatg tggggaaagg gattataaaa cataagtata aggataaaag tatagagttg
     3241 actaaaaacg aaataaaaat tttaacatta ttattaaaaa ataagaatag ggttgtatca
     3301 agggaaagtc ttatgatgac tctatgggat aatgacgagt ttgtgacaga caatgcactt
     3361 actgtaaata tgaatagatt gagaagtaaa gttaaagaac tgggttttga tgattttata
     3421 aaaactaaga aggggatagg atatataata caatgctagt aaaatatttg aaaggtaggt
     3481 ctaagtatat tgctctacct ttagttgtag ttagtataat aaatatctac ttatttgcta
     3541 tagatatttt taaaaataaa tattcagagt taatatattt agatttttta gtgctgttta
     3601 taataatggt attttttgtt atagattata taaattttag aaatagttac acaaatttat
     3661 ataattgtat agaaaatagt ggtgaaatag atagttattt agttgatgga caatcttttg
     3721 aagaaaatct aataaaagat attatagaaa acttaaaaat aaaaaataat agtgacatag
     3781 agacttataa acaatcatta aaagaattgg atgagtacat agctaaatgg gttcatgaaa
     3841 taaaaattcc aatatcttct ttaagtataa ttacagatag gttaagtagc atagaagata
     3901 gtttggatat taagaatcag gttgcaaaga taaatttttt agtaaactct attttgtata
     3961 gtagtagaag caacactatg tttgaagatg tatttataaa taaatttaat ttagaaaaat
     4021 tggtaaaaat gtctataaaa aataattcat ttttgcttat aaaaaataat gtagaagtta
     4081 gtttgaatga attagaaaat gatgtttaca cagattctaa atgcatgtca tatgttttag
     4141 accaaattat taataatgct ataaagtatt caaaggaagt tggtaagatt gaatttaatt
     4201 caaaaaagtt agaaaatgga gtggtattat ctataaaaga ttttggtata ggtataaatg
     4261 aggaagatat atctagggtt tttgacaagg gatttacggg gaaaaatgga agaaatcaat
     4321 tgtataagtc tactggaatg gggatgtatt ttgtaaagaa aatgatagat agtttagggc
     4381 atgagattga ggtatgttcg aaaattggtt catatacaat ttttaatatc tacttttatg
     4441 atatatcgga ttatttaagc atagatagtt aggttattag actataaaat ctatcatcat
     4501 atacaaatcg acatatacaa taagaataaa tttagttctt gaaaatagtg aagatttaat
     4561 tagtgcctta aatgatgctc catctatatt ataaaataat aattattata tatgaaaaac
     4621 atatcagata ggtacctggt atgtttttta tttgtagtaa ctattttaat atggtttttg
     4681 gagagagaat atgttttgtt tgtgaaaaaa aattacatgg tattacattg acactgaaaa
     4741 taaattaatg taagatttag ctaaggtaaa aaacgtgtat aagattaact cgattaattt
     4801 cgtaagagta aattatcgta attaaagatg aaataagatt aattctaaaa ttattaaact
     4861 taataccttg atttggggag gaataactat aaacttaaaa ggatgataac tatgtatagt
     4921 gtaggtttaa tgtcaggaac ttccttagat ggagttgatg cagtactagc tgaaattagt
     4981 gggaatggta gaaatactaa agttaagcaa atagaattta taactctaga aattcctaaa
     5041 gatataaaag acgaaataag aaagtgctgt atagaagagg aatcgagtgt tgatttaatc
     5101 tgtagcttaa attttaagct tggatattta tttagtaaag ctgtaaaatc agtgtgtcat
     5161 aaagcaaact ttcatatagc aaatttggat tttatcgcat ctcatggtca aacaatcttt
     5221 catataccaa gaagttataa taattttgta tcttcaacgc ttcaaatagg tgaaccagca
     5281 gttatagcat atgaaacaaa tacaaaggta atatctaatt ttagagtaat ggatatagca
     5341 gcaggtggag aaggtgctcc attagtacca tatagtgaat ttttattata tagtgataac
     5401 aataaaaatt tagcacttca aaatattggt ggaataggaa atattactat aatacctaaa
     5461 tcatgtaaca tagatgatgt atttgcattt gatacaggac caggaaatat gataatagat
     5521 ggagtatgtc aaagattatt taatagaaag tatgataaaa atggatactt tgcatcaaaa
     5581 ggtaaaatta atgaagaaat gttaaaagat ttgatgagtc ataagtatct tagtcaagcg
     5641 ccacctaaaa gcactggaag agaggtattt ggacaagttt atttggataa catgcttaac
     5701 aaatataaac atgtagataa atatgatttg atagcaacag taactatgtt tacggcaaaa
     5761 gctatatatt ataattataa aaacttcata cttccaaagg ttaatgtaga tactttatta
     5821 attggaggtg gaggagctca taatctaact ttaataggat atataaaaga gttattatta
     5881 gaggttgaag tattaactca agatgaatat gggtattctt ctgatgcaaa ggaggctttg
     5941 gcatttgtaa tcttgggcaa tgaaacatta aataattctt tttctaatgt aatatctgca
     6001 acaggggcta aaaataaagt tattttaggg aatataacac ctaaaccttt tggaggtaaa
     6061 tgacatgtct aataataaaa aaaagaaaag aaagaaaaat aataattata aaaatgcaaa
     6121 aagtacaaaa agtaataaaa atactaagaa acaaatggag aaaaatcaaa gaacagatta
     6181 taatattcca actataagtt ttaaaagtgg attaatacta atagtttcat ctcttgtaag
     6241 tactgtagtt tttcctttgt tattatctat atttggaata gataatagat ttggagttgt
     6301 tataggaaat tcattaatta catcttttgc agttgcatat acaagatact ttgttgaaac
     6361 taagagaggt ttttctttgg gattttttag actgtatatt ttatttgctt tatcatttgc
     6421 aataataggt tacttctgga tatataaagg aatacatatt taaaaaagta ttgagactat
     6481 tttatgttaa taataagata gtcttttttc ttttttaaga aaagatatga gtattttaag
     6541 tagtgtgtaa ttttagacaa aagaatgatt agataaataa agcaattaaa gcaagatata
     6601 aatgcatgaa ataaaattac aatttaaaat gtaaaatatg aaaaaatata tacaaacgta
     6661 ttcctgtaat caaaaataca tgctataatg attgaaaaga aataaaaaaa cagggggaat
     6721 caatatgaga gtattatttg tttgttcatc agggatgtca agtgctatag cagttaatgc
     6781 attacaaaaa gaaggagcaa aaaatggaat agatatagat gttttggctg ttggtactca
     6841 agagtttgag aatgaagtta aaaatggatg ggatattgct atggtagctc cacaagtcag
     6901 acatagattt gactatttaa aagcttttgc tgatgaggtt agtgtaccat gtgcattaat
     6961 acaagcacaa gcttatagtc cattaggagg accaaagtta ttaaaacaag ttcaagaact
     7021 gttgagtaaa tagtagttgc agtgttgtta gattagaaga aagttgattt tataaaaatt
     7081 ttaatgataa taaaaataaa tattaattaa ggagagaaaa gatgctagat aaatttacag
     7141 aatttttaga cactaaatta tcaacttcta tggccagatt ggcagaacaa cgtcacttaa
     7201 gagctgtaag agatggaatc gtagcttcat taccacttat aatagttggg tcatttttct
     7261 tgatattagc atttcctcca ttaccagatt catggggggt aactcagtat ctaaaggaaa
     7321 atgcagttac aatattacta ccatatagaa tgacattttt tattatatca gtatattcta
     7381 catttggcat aggttatagt ttggcaaagt catataagtt agatggattg acaggaggtt
     7441 tattagctac agctacattc cttttgacaa tagttcctac tgcaatagag ggtcttaccc
     7501 ctgagttatt aaagatagtt gaaaagagtc cagaactttt agcttggtat aattcaattc
     7561 ctcaaggatg gcaaatgcca atggctaatc ttggtggagg ttcaatgttt gttgctattg
     7621 taacatctat aataggtgtt gagatttata gatttactga caaatctaaa ttcaagataa
     7681 ccatgccaga agcagttcca gcatcagtca caaggtcttt tgaagctctg acaccagccg
     7741 cattaataat aattttaatg gctattgtta cttatttcct agggtttgat tggcatggct
     7801 tcatagctaa attagtaact ccattagttt cagccactga cacattacca tcagtaatta
     7861 tactaatatt tttaataacg tttttttggt catttggaat acatggtgta tcaataatag
     7921 gttcattggc aagaccttta tggatacaat tattagatgc taatacagct tcatatgctg
     7981 cgggtcaagc agttccaggt attgctgctg aacccttttt tcaatggttt atatggattg
     8041 gaggttctgg agctacaata ggcttagctt tacttcttgc atttagagca aaatcagctt
     8101 atggaaagtc tttaggaaaa gcaactgtaa taccagcaat attcaatata aatgaaccaa
     8161 taatatttgg agcaccaata gtattaaacc caatattaat aataccattt gttgtagcac
     8221 caatagtaat ggcaacagtt tcatggtttg ctatgagtgc taatttagta tccagagtag
     8281 tagttactgc tccttggaca ttaccaggac cagtaggggc atatttagcc actggtggag
     8341 attggagagc ttcagttctt aacttattat gtatagctat atcaataata atttactatc
     8401 catttgtcaa gatgtacgat aagagattgc ttcatgaaga aaaagttgaa gagcaagaag
     8461 cttattaatt agaaactata ttggaaatta aaaactatat tagattagta taaatttcaa
     8521 agtataacag ttatgaaata agtaacgaag atattttgtt gattgtttat aaaaaaagaa
     8581 aaggtaaact tttctttttt tataaatata tatgaaactt tttttcacca aatttttaaa
     8641 aaagtttcgt gtaattcgaa ataaatttaa acacatatag gatataagga gatgacacag
     8701 atgggaagat taggaatatc aatttatcca gaaaaaacaa catctaagga aatatatgat
     8761 tatatagata aagctgctga aaatggattt acacgtatat tttcatgttt attatcagtt
     8821 aaagatacta aagaaaatat aattaaaaaa tttaaacgta taaatgaata cgctaagttt
     8881 aaaggttttg aggtaatact tgatgtaaat cccagagtat ttggtgaatt agaaataagc
     8941 tacaaagatt tgactttttt taaaaagacg aaggcagacg gaataaggct tgatatagga
     9001 tttacaggtt ctgaagaggc attaatgact tttaatcctc aaaatcttaa aatagaaatc
     9061 aatatgagta ataatactaa ttatatagat acaataatgg actaccaacc aaataaagaa
     9121 aacttgacag gatgtcataa cttttatcca catagatata gtggattaaa tttagaacac
     9181 tttataaaat gtacagaaag atttaataag tatggattaa gaacagcagt ttttgtaaca
     9241 agtcaaaatg aaactacatt tggaccatgg cctgtaactg atgggcttcc aacaattgag
     9301 atgcacagaa atctacctat agatattcaa gtaaagcata taatagctat gaataatata
     9361 aatgatataa taatatcaaa ttgttatcca acatatgagg agctaaaggt attaggttct
     9421 atgagaaaag atatggttac atttgatgta gcaatagagg aaaatatacg agaagttgag
     9481 aagaagatac tctttgaaga aatacatttt aatagagggg acatatctga cagtctgata
     9541 aggtctactc aatctcgtgt taaatataaa ggatacaaat ttgaactatt taatactcct
     9601 aaaataataa aaagaggaga tatagtaatt gaaagtagtg aatatggtca ttatgcaggg
     9661 gagttacaaa tagccttgac tgatatgaaa aacagtggta aatcgaatgt agtaggatat
     9721 ataagaaaag aagaattatt tatattagat tatattaaac catggcaaaa gtttaatttt
     9781 aaaccctcaa caaaataatt tattatgaaa atattaattt attataaaaa tataattatg
     9841 aaagttggaa ttaaaatgtg tttaaaaatt taatattaag aaaatgagga aatgatatgt
     9901 taataaaaac tttagaaaat ttagttacag aaggtagaaa taagaataca ttgcaaatag
     9961 ataaagaaga tacattaggc ataatagaat taataaataa cgaagataaa actgtagcct
    10021 atgctgttga agaacaaaag gagagtatag caaaagctgt taatataata gtagatagaa
    10081 tgaagcaggg aggtagatta ttctatatag gagcaggcac cagtggtagg ataggaatac
    10141 tagatgccac agaatgtcct ccaacttacg gagtggattt tgagcttgtt caagctataa
    10201 tagctggtgg aaatcaagca atatttaaag caatagaagg tgctgaagat gataaagaac
    10261 ttggaaagca agatataata gatagaggag ttacatctaa ggatgttata tgtggtatag
    10321 ctgcatcagg aaggactcct tatgttatag gtgcaatgga gtatgctaag gaattggggt
    10381 gtgcagtact atcaataact atgaatccga atagtgaaat gagtaaaaaa gcggatttac
    10441 caataaacat tatagtaggg gcagaagtaa taatgggttc aactagaatg aaaagtggta
    10501 cagctcaaaa aatggtatgt aatatgttaa caacagcttc tatggttaag atgggaaaag
    10561 tatactcaaa cttgatggta gatgttaaga catcaaatga aaagttggtt gaaagagcaa
    10621 aaagaataat aatgatagct acaaatgtaa aatatgatgt tgcagaaaaa ttcttagaag
    10681 aagcagataa tagcgttaaa ttggctatat ttatgataaa aagtggttta gataaggata
    10741 gtgcaaagag tatcctagat agacaagaag gttatataag tgaagcttta aaatcaatag
    10801 aaaaattgta aaataaataa tagtactgat aacctttcaa tattaaaaaa acagcattgg
    10861 aaggttattt ttagatatta agtattgaaa gaattattaa agatattgta ggaggatagt
    10921 atgtattttt taggtgtaga tggtggagga acgaaaacaa catttacatt agtagatgaa
    10981 gaattaaata tagtaggaac cataaccaaa ggaacttgtc attataatca aataggattt
    11041 gataatctaa cgaaattatt aataactggg ttggaagaag tttgtaaaga tgctaagata
    11101 aatgtagaag aaataacgta tgcatttgtt ggacttgctg gatatggaaa aataaaagaa
    11161 gtattgtatg cattagaagt agcaacaaaa aatgcatata gtcatataaa ttatactcta
    11221 ggtaatgatg tagaaatagc attagcaggt tctttaaatg gggaaaaagg tataaatata
    11281 attgcaggta ctggttcaat agcacaggct ttagataaag atgggaatct tcacagatgt
    11341 ggaggatggg gctatgtatt aggagatgaa ggttcagcgt attatatagg aatggctacc
    11401 ttaaaaatgt tcacaatgca gtctgatgga aggtgttcaa aaacaaaatt atatgattta
    11461 ataaaaagac atcttaatat agagaatgat tatgacataa taaaatatgt aaatgatgaa
    11521 atacaaggag atagaataga aatagcaaag tttgctacga tatgtttaaa agcagttatt
    11581 gaaggtgata atactgctag taaaatattt gatgatgcag cttatgaatt aagtaggctt
    11641 ataataggat tagagcatca ttttgaacaa ggtacaaaga taaaggtatc ttattcaggt
    11701 ggagtgttta agtcaggaga tttaatatta gagccactta aaaaatattt gaataaaacg
    11761 agatttggta tagtgagacc agtgttgact ccagatttag gagcatgttt acttgctaag
    11821 aagaaatatt atagtaaata ggtagaggtg atagagtatg agttgcattt taaaattaaa
    11881 acagatatat gaagatttaa cggaagtaga taaaaaaata gctgattaca tacttaataa
    11941 tacagaggct ataagtaagc tttctgtatc agaattggcg tcaaactcaa aaacaagtac
    12001 agcaagtata gttaggtttt ctagaaaaat gggatattcg ggttttgggg atttaaaaat
    12061 tgagatagct aaagatttga tgggcaaaga aaatgaatac acatatgtag atgaaaacta
    12121 tgattgtaat atagatagtg ttataaacaa aattacaaac aaaaacatag agactatcaa
    12181 ccaaacaagg ttgttgaatg aaaaagatat aataaaagaa gcagttgaac agataataaa
    12241 ggctaaaaat gtatatatat ttggagtagg tggttcggct ttagttgcac tagatttaca
    12301 gatgaaactt ttaaggataa ataaacaggc atttacctct ttagatagtc atacacaact
    12361 tatggtatct tcaaatgtag ataaagaaga tatagctata gcaatatctt actctggaga
    12421 atcaaaagaa gtaataaagt ctatagaaaa tgcaaaatta aaaggatgta aggtcatttg
    12481 tataactaaa tatagtgaca atcatcttag taagattagt gatttaaagc tagtagtacc
    12541 aaatatagaa aaaagactta gagaaggagc tatttcttca agaatagcaa tgcttacgtt
    12601 gatagatata atatatattt ctataattca agaaaactta aatgaggcag aacagaaact
    12661 acaagaaaca aaaaggatac ttgattattt aaatattaat aatgcttaaa actaggttat
    12721 atatcaacta aacaaataag ttaggctata agcgtaagtc aataagaaat agataaatat
    12781 ctaaaatatt gacttactta ataataatat atagcatttt tataatacaa atgagttgtc
    12841 ttaaaattga ttttttttaa tcaaatttta agttcaactc cttttttata tttttataga
    12901 tatatcctat attttcccag aaaacgtatt gaatatacaa attataagaa gtataatgtt
    12961 gttgggagag aatgtatgaa atgtatacaa agttgatttt aactgtatta ttgataattc
    13021 tctttactct taccattatt aatgattgaa gacaatggta tttattatag gtcaaagatt
    13081 ccgaatgtat taatcatcat cattttctca aactaacagc aaataccctg atttgcgagt
    13141 tgtattgtat acaaattatc tagaaaatat ctattagatt ttccataaaa tttaaatatt
    13201 tcacgaatgt atgaatggag aaatatacat gttgacaatc caccttttta aatactaaat
    13261 taattttatt aatggtagag aataggaagt aacaatgttt tataaaggag aatattaagt
    13321 atgaagaaaa ttaggaagtt aactaccaag ttattgatta caacaatagt tttaatctca
    13381 ggtatgagta tgacagttta tggtatgaca gccaaagagg taacagcaaa aacaccaaaa
    13441 agctatgtca ctggaaccaa tagcgtatat ggtccaaagc tgtcacaagc ccaactaaac
    13501 tcagtagcac aagcaacagc agattttatg aacaagaaaa tcacaaagaa tatgaccaca
    13561 gatgctaaga ttttagttgc ctacaatcac attaaaaata acacaacata tgttgactgg
    13621 aatgcagtag agggagcaaa tactgcctat acattggtta ctaaaaaagg tgcatgctca
    13681 ggaatggcta ggagcatgaa agctttgtgt gatgctatgg gaattgaatc ttattatgta
    13741 cacagcacat caaatgacca ccagtggaat cttatccgtt ttggtgatgg gcgtttgtat
    13801 catgtagata ttgatgctaa taaatcagca ggaaaggata tcatatacaa gagtcttagc
    13861 cacccattac catttgataa gacagcatat ccaaaagttg gtgcaatagt acagacggta
    13921 aaaccagaac agacacagaa accagcacca cctggaaagc acactatgtt accacatcaa
    13981 gaaggggcaa aggctgttgg aaattttgga aaaaaaggag aagatataaa tgaaaaacat
    14041 gtaatgtatg aaggtgttag atgtagtgta gttaattcat cagtaaatac aattacattt
    14101 acaggtagtg aatcaaattt agacccatca aatcttacga ttgctgtaat aggatttatg
    14161 aacacaccat atgggatgtt tgcattagca ccagagggta aacctgttga atatcctttt
    14221 aaatatgata agccattttc tttagatttt agtggtaaaa atcgttctgg tgcagaatta
    14281 gcgaagtact gtaaaaaaaa tgatgtgact attaaaatag aaatcactga tgaaaaagct
    14341 aatattggac ttggtcaaat aatgtatgtt cgatatgaat aatgatttaa tcatgacagt
    14401 agaataagtt ataaacattg cgccctctta ctaggggcgc atttaatatt atatctgata
    14461 ttttgtagtc aggtcaactg ctagatttct ccccttttta tttataaaaa ttattatctc
    14521 taagtatctg agcatgttta cgattaacta aaaactgttt taactcagtc aagcatagga
    14581 ataaaatagc tctattttca aactctgttc tgtcaacagg cagaggctgg tttttcatac
    14641 taagcattag tctctttaat tcttcaagaa gaagattgcc tgtttcagct tcaaattcag
    14701 tataacctat cttatgtata aaagcagata gaatatgagc ttgtggtggt gtagaattta
    14761 gttgagatac ataactatac aaattttcta agatatcccg ttggcttttt ataatatcca
    14821 tatgttctaa gaagaatcta gtatcactta ataaagtatt attaatatta tcgtaagttt
    14881 cagaaatact gctgtcaata agtgaattta atgtatataa atctctacta tatccatttt
    14941 cttttttagg atttacaata atatctgcaa tgtctataag tacaatactc acttcttcct
    15001 gtaacttttt ttgaacttca tggattttat gtatatttgt tggaatatac atatttatta
    15061 agacacctat tccagttcct actgcaaata ttccagcttc atttaaaatc catttgatag
    15121 aagtttctcc ttgaaggtag taatgggatg ctatgactac acacatagca ataacatctt
    15181 gaatatttaa caaaaaacaa agtggtataa ttataaatat aaatattgaa aatgaagtca
    15241 aattatatcc taaaatatta aaacataaat atgaaaaaat agtacataaa agaaaaccat
    15301 aaatctttcc aatggagcct ttaagagttt ctcttttagt gtcctttact gtaagtagta
    15361 ctataactcc agcaaccatt gaatattcta attttaatag ccaagcaata aatatagcaa
    15421 gagaacatcc aagagataat tttattactt taagtgaatt aatattattc aaatgcaaac
    15481 ctcctgtaaa tcaatataat aaaattctaa cataaaacta atattgcttg aaaggtaagt
    15541 aactatactt aattatttta ttgccctatt tgtttagata caatcaatat aattttattt
    15601 tatgaaaatt ttttgtaaaa ttttaaattt agagactaac atgagaccac aaagaggaag
    15661 tttattataa gaagaaaact taaaattgat tttaaatagc aaatgaaaat aatcaaatat
    15721 gtatatacta ttattaaaaa ataaaattat atagttaata taattttata attggtttag
    15781 tatagagatt tttaactttt atgttatact atttataaaa gtaggtataa agattaaaat
    15841 acataatcaa atatgtataa gaggttttaa atagtattgt taatgaactt gattattgtt
    15901 tataattaca aattggagga gataaacatg aaaattactg aaggatatat gccttttaaa
    15961 ggttttaaaa cgtattaccg tatagtagga gaaaatacgg aagggaagaa gccattagta
    16021 ttacttcatg gaggtccagg ttctacacac aactattttg aggtattgga taagatagct
    16081 gaaagtggta gacaagtaat aatgtatgac caaattggtt gtggaaattc atttgtagaa
    16141 gggcatcctg agctatttaa tgcagatact tggatagagg agcttattga actaagaaaa
    16201 catctaggac ttgatgaaat tcatctgtta ggtcaatctt ggggaggtat gcaggctatt
    16261 tggtatgcta ttgaatataa accaaaaggt attaagtctt acatcctttc atctactctt
    16321 tcttctgcaa aactttggga gaaagaacaa aaaagaagaa tatcatatat gagtgaggtt
    16381 gaccaaaaag cattacttga tgcagtaaat actggagatt actctagcaa agaatataat
    16441 gatgcattag aaagatttat ggaaatgtat tgtgcaggtg aagtgacaga agattctcca
    16501 gagtgcctga gaagacctaa aaaatcaggt tctgaagcat atattgtagg atggggacaa
    16561 aatgaatttt ctcctacagg aactctttct ggatatgaat ttacagatag attacatgaa
    16621 ataaaagagc cttgtctagt aactagtgga gcaatagatt tatgttcacc atatattgca
    16681 aagactatgt atgatagaat acctaatagt aagtgggaat tatttgagta ttcaagacat
    16741 atgccattcg ttgaagaaaa tgagaaatat ataaaagtct taactgagtg gttgaatgcg
    16801 aacgattaaa aactatataa acttatataa aaaaatgagt gtctcaaaat gaacttttta
    16861 gttcattagg cactcttttt gcatgaaatc aaatatattt tcattatttg aacgataaaa
    16921 tgaggcttat atctactttg ggaaagtaat tttttattac tagcgttaga ttctaatcta
    16981 attgtatacg tattgaaata atagaaatat attggtgttt ataacttaat tttattgttt
    17041 tttagaaatt tttttatata ttggtataat tattctgttt aaatttgatt aaaaagtata
    17101 ttaattataa taagaaacaa ttatataaat aggaatagat tattataatt aatatagata
    17161 taaaaataat tatagaaaga aaggcacatt atggaaaaat tgagagttat tgaaatgata
    17221 aaaaataatc ccaatattat agctacaata gataatccaa ctgatgaaat gaaattgtta
    17281 gctattaaag aaaatgggct tgtactagaa tatataaata atccaaccag agagatgcaa
    17341 gaactagcaa tagataataa tattagagca attaaattta tagataatcc aacagaagat
    17401 atgatgataa aagcagtaaa tgagggatgg agtatactgg attatatcaa aaacccaact
    17461 gataaagtta ttgaaatggc tataaatcaa gcaggatggg caattaaata tgctaaaaat
    17521 ccaagtgaag aattacaact gttagcagta agaaaaaatt atgattcgat aaagtttata
    17581 aaacaacctt atgaaagtgt acaagaggag gcagtgagaa taagttatga tgccttgaga
    17641 tatatagatt cacctagtta taatgcagaa cttatagcta taaaaaataa tgaagcagct
    17701 attagcttta taactgattt agataaaaat aaaatgttgg aatttttaaa agtgaatatt
    17761 ttagtgatta agtacattct gaaaaaagta tctaaagatg aattagagag tgtattaaaa
    17821 gaagtattat ccaaagaaga tgttgaggaa aagtatatta gagatttttt gaattgtagt
    17881 gttatagata gaaatagcga aagtatacca atagataaaa ttatgtttat ttataaatat
    17941 ggaagtaaga cagcaaaaaa aatagctgta gatgagaaat taaagattat gtaggagaga
    18001 gaaaaatgaa ttttatagac acattaaaaa gcgttgactt aatattatcc actggagaag
    18061 tacctttaat agtaggtgaa agtggaatag gaaaaacagc tttagcaaat aagcttgcca
    18121 aagaaaatga ttggagttta attgttattg atggaaactt acttaaagag ggtgaaatag
    18181 gtggtcttcc aactatagaa tcttatgtag gagttaattc taatggatat aagactgaaa
    18241 agaaaacaac agtgtatgct gttcataaca aattaagaga aattgatgaa gagatatcta
    18301 aaagtaagac agttctttta tttatagatg agataaatcg ttgtgagcat acagtacagc
    18361 aagaacttat gaatttaatt ttaaatagag aaattaatgg atataaactg catgatgatg
    18421 taaagatttt agcagcaatg aatccatcaa gtaaatatgg ttcagatttt gattatcaag
    18481 tggtagatat ggatgcagcc caagaaaata ggtttgtttg gttaaatatg gagagtgacc
    18541 atacacaatg gataaaatgg gcaatagatg agggtattga aagaaaagtt atcgagttta
    18601 tttccacttt tccagaatat ctgcataaaa taaatgaaga tgatgtaaga gccactccta
    18661 gaagttatga gagagtatct aaaatttata aagtttataa agaaaaaaat aattctattc
    18721 ctagagcagt atttttaaat gttgtaaagg gtaatgtagg taaagttatt gcagaagaat
    18781 ttataagttt tattgaatca aactctgaac cattaatatc ctatgaagat gtttttttag
    18841 gagaatctat tgatgagtct attgtagaaa gagtaaaaaa tgagagtcat acaagacttt
    18901 atctatcagc tatgaacatt ctaaaagact tagaattaaa tattaagaat gataaatatg
    18961 aatcaaacca ctatattaat agatttattg aatttttaaa aatgtatcct gtagatttaa
    19021 tgataggtat tatgaaggat attagaaaca gttatattga agtatataaa aaagctatag
    19081 aaaatgaaga gtttgtaaaa tcatattttg aatcttatag tttaataagg ggataatgta
    19141 tggaaaatta ttttgataaa caagcaaaag agctttataa taaagcaagt gaaattataa
    19201 atactcattc tatgctaaag gcaaatcgtg ctaatgagaa atttgatata gatataccac
    19261 aagattttaa gtatgagttt tttagtcttg tagataaagt gaatttaagt cttatggaag
    19321 aagaagataa tttttatgga tattttttgt ttcagatgtc aagagaaata agatttgata
    19381 taagtagtcc tacaggtgtg aattttaagg gagctaaata tgttatatat tttaatccaa
    19441 taatcttttt aacgcttgac ataaagcaaa tggagactac aattaaacat gaaattcatc
    19501 atatattatc tatgcatttg atgagagcaa aggagttaaa aggaaagtat agtacattag
    19561 caattaatat ggcaatggat atagtagtaa ataaatttct aaacaattta ccaccatatg
    19621 caactacctt agagtgggta aatttaaagt attccttaaa acttgaacca tatgaacctt
    19681 ttgaatatta tgtagaaaag attcagactg aattagattt gatggaagtg gatgaagatg
    19741 gtgaggaaga tgatagtgat aaatatggag atatagaaat tgattatagc cccgaaagaa
    19801 ctcatgatat atgggatgaa tccaatgaga tagatgaaaa tacccttaga gaatttactg
    19861 aaaaatttat taacagttct caaaaaggta aagttcctgc ttatttagaa agtatgatat
    19921 catcacttaa aaatagtaag ggtgaattgc catggaattt atatcttaat agaataatgg
    19981 gaacagttga aaataataaa aagaagacta taacaagaag aaatagaaga caaccaaatc
    20041 gtttagattt gaggggagaa cttagaagtc ataagtcaga aatagcagtt gcacttgatg
    20101 taagtggaag tattagtgat gaagagttta aacaagctat taaagaagtt cttagtatag
    20161 tgaaaaacta taatcatgaa attacaatta tagaatgtga taatgaaatt agacgtgtat
    20221 ataaagtgag aactgaaaaa gatataaaag atagaattag gataggtgga ggtactagat
    20281 tttctccagt ctttgagtat gctaataata aaaagattaa tttgttagtc tactttactg
    20341 atggtaaagg tgaaaataaa ctacaagtaa tacctagagg gtataaaatt ttatgggtta
    20401 tttctggaag aggagataaa atttcattaa aagaacctta tggagcagtt aaaaaactta
    20461 ctaaggttaa aacaaatgat gaaatattag aaataaatga tgtaagaaat gatgggtact
    20521 caatgaatag ccaagcacca attttatagg tattcacagg agataagctg tattaattta
    20581 ttttgatatg cttgttataa aaatctaaaa aatacattaa tcaatggtta atgtattttt
    20641 taattttaat aatataagtt ttacttacat ttaagtctta aaatgtgtta aaatataata
    20701 tatagcagat agttttggca aggtggattt agttgtcaaa actatttttt ttattaagga
    20761 tggtgatgtt tttgtttaag attgatgatt atataatgta tggtatgaca ggagtctgca
    20821 aagtcatgga tataacaaat gaacgattta caaatggaat aaaaaaagag tattatgtat
    20881 tgagtcctat ttattctaat aatacagtaa taaaaattcc tgtagataat gaaaaagtac
    20941 caatgagaaa gttactttct aaaattaatg tgctttcatt aataaatgat attcctaata
    21001 tggatacatc atggatagat aatgaaaaat tgagaagtga gcaatttaaa aaaatactca
    21061 gaggtggtaa atgtgaagag ttaataaaat tagtaagaag tatagataat aacagagagt
    21121 atgtaaaatc tattggtaaa aaaacacatc aagcagatga taatataatg aaagaagctg
    21181 aaaggttatt aaatgaagaa tttgcaacta ttttagatat ttctcctaat gaagttagtt
    21241 catatatttc aagtcatata cctcaataaa gtgttttagt atcctttatt taatctattt
    21301 taagtattat ttatgtatgc tggttttggt aaaataaaat atataattaa attatataaa
    21361 aaataatgat gattgtattg aagaattaca gaatagtgcg gagagcctac tcctttaggt
    21421 gtgagatgga tatcacttaa agatttaaat tgttattgta gatgttttta atataaaaca
    21481 agattaataa gtgtattgta agctttaagt gaaattgata ctataatgag ttacttagat
    21541 tttaaaatat ataatattat aaaaaatcct tttaggtttt gaatgaataa gatggatact
    21601 atgttgaata gaatccatct tatttaagtt ttatttatgt tgtttatttg taagcattat
    21661 ttttgtacat gaaaacacag tgtaaaaata tgcttagaat tatgaagttt tattaaaaag
    21721 atattcgaca aaataagact aaaaatattc ttaaacttat aactaagata aagattgtat
    21781 atttatagtg tagcctgaaa aattgtggat gtacgaaatt tatttagtat tttattgaaa
    21841 caaagtagaa gaagtactat agtttatctt tgaatagatt gttatttttt agtgaaaaag
    21901 ttattaggtt aatacataaa tataatagct tataaatagt ttaagcatgt taaaaaagta
    21961 gttattagag atatatagtt acattgctta taagatactt aaaatgatag cattcactta
    22021 tatttagaaa attaagat
//
LOCUS       DAEPID010000067        21829 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.067, whole genome shotgun sequence.
ACCESSION   DAEPID010000067 DAEPID010000000
VERSION     DAEPID010000067.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 21829)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 21829)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..21829
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.067"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            259..1566
                     /locus_tag="KR257_002810"
     CDS             259..1566
                     /locus_tag="KR257_002810"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728608.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0031490.1"
                     /translation="MKEIADAITSEYLSYGINEDISIYEGRFCIYLDKKYRCNGKIYY
                     KMTPPISISFKADIGCVEEIDNEDDNLALDYDNAILEVHGYKIISITINTLSEFSVEG
                     YINDDCIKSKNSYVEYVDFNIINLDKIPGKLIKYNDKVYAGRIEFDINDYVVTIDKRY
                     DYRKELKSELKSKSGAIITHIGRIRRKDGRIFRTNNTINLLDRISTALSFMCGRYVGF
                     CLAKGYRSGNEVYRIWNENQISPFRYVPTWSDTLSNYYNMEKYISLMCKKLEDFYYGS
                     AIKSVVDWYIESLGSATMENNIISVQIALETLSYVILVEQNKILTDEVFDCNLASKNI
                     RLLLDTCKIPYGKHELNIFDNIIKNKFDDGVDLVIYLRNSIVHPSRKTHRAVLEVEDI
                     WNIISIGTRYIELVLLFILGYRGEYSNRLVERCYGEVEVVPWN"
     misc_binding    1652..1914
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00230"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="T-box leader; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /bound_moiety="tRNA"
                     /db_xref="RFAM:RF00230"
     gene            2040..2843
                     /locus_tag="KR257_002811"
     CDS             2040..2843
                     /locus_tag="KR257_002811"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423750.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amino acid ABC transporter substrate-binding
                     protein"
                     /protein_id="HBH0031491.1"
                     /translation="MKNILKKVGIFTIMLGLLGGVVGCSKPDNEKDKDASKESKKEVV
                     VGFDNTFVPMGFLDEKGDTVGFDVDLAKETFKRLGMEVKFQPIDWSMKETELNDSKTV
                     DVLWNGYSITDERKKIVSYTEPYLQNKQIIVTLSDSKINSKADLKDKEVGTQQGSTAL
                     DAVEKDKDFMNSLKGGAPVLYDTYDKALRDLEIGRTSAVVGDEVLIRYYMGQKGEDKY
                     KVLKDDFGLEDYVVATSKENPELCEKINETLKEMKKDGTFDKIYDKWFK"
     gene            2881..3492
                     /locus_tag="KR257_002812"
     CDS             2881..3492
                     /locus_tag="KR257_002812"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430270.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amino acid ABC transporter permease"
                     /protein_id="HBH0031492.1"
                     /translation="MLQGLEIVIAMFCITLIVSIPLGIGVAFLRLSKNKLVSGITQCY
                     ILIMRGTPLLLQMIVIFYGLPLLGIVFDRFTAGVVAFFLNYAAYFAEIFRGGIQSIDR
                     GQYEASKVLGFDKFTMYKRVIFPQVFKRILAPISNEVITLVKDTSLVYILGLNDILRI
                     SQIAMNREASLLPLFEAGAIYLIFVAILTKGFELLEKKYSYYR"
     gene            3524..4195
                     /locus_tag="KR257_002813"
     CDS             3524..4195
                     /locus_tag="KR257_002813"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430271.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amino acid ABC transporter ATP-binding protein"
                     /protein_id="HBH0031493.1"
                     /translation="MLKIKNLNKSFKKNRVLKDISFELEEGQIGVLLGKSGAGKTTIL
                     RCINGLEEFDSGEIIIDNEVIKNKRDMAKIRGKIGMVFQNFNLFPHMTVLENIIESPV
                     NVFKVPRKEAEERARELLRLVDLEDKLNSYPFELSGGQQQRVAIARSCALMPKVLCFD
                     EPTSALDIDTIQRVVNIMNRLKDKGMTILIITHDVVFSNNVADKIISIKDGIVENVQI
                     KEKIV"
     gene            4493..4855
                     /locus_tag="KR257_002814"
     CDS             4493..4855
                     /locus_tag="KR257_002814"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003433620.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="arsenate reductase family protein"
                     /protein_id="HBH0031494.1"
                     /translation="MIKLYGYTKCSTVKKAKNWLKENNLEFEDIDMVQNPPSKEELKS
                     IYKTSGYDIKKFFNTSGMKYRELGLKDIVKTESDDKLLEILVSDGMLIKRPLLLDGKN
                     VLLGFKEDVWKSTLLKED"
     gene            5291..5992
                     /locus_tag="KR257_002815"
     CDS             5291..5992
                     /locus_tag="KR257_002815"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423765.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4253 domain-containing protein"
                     /protein_id="HBH0031495.1"
                     /translation="MSIEDLYDFECVPLNNEIDIDVLFEKMIEDGKEKEYTPIIVIDE
                     KVGLLRKNIDMITKEYGSLENYREYCLTKYNEIDVNQFFDFRKSEISELLKELIDLED
                     DFYDYKHFRPIMNIDIFHEYNKVYIAKIPTIKPYEVFAYIPIGGFNDCPRDEEHIAIA
                     KYWYEKHGIFPIAIGCDTVQYSVKNLTKDGKKFDDLCIELVFYCEDIIIQGYETLKAL
                     KDVLKRSTIVLFWWD"
     gene            6262..7080
                     /gene="larE"
                     /locus_tag="KR257_002816"
     CDS             6262..7080
                     /gene="larE"
                     /locus_tag="KR257_002816"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423767.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-dependent sacrificial sulfur transferase
                     LarE"
                     /protein_id="HBH0031496.1"
                     /translation="MEVNFVKEKEKLDKLKKMLLELGSVVVAYSGGVDSNFLLKVAKD
                     TLGENVIAVTIHAMMHSSREIEEAKQYTQNFGVKHIILNIENFDLKEFKENGVDRCYH
                     CKKYIFSKIKEVAKEHNIKYIVDGTNIDDLGDYRPGLKALSELGVISPLKDSSLKKEE
                     IRSLSKTLGLNTFNKPSFACLASRIPYGVEITDENLRIVEKSEEYLSNLGFSQFRVRM
                     HGDIARIEVGQEELGKFFENNNFNKVDTKLKIFGFKYVTLDMSGYKMGSMNLNV"
     gene            7135..8283
                     /locus_tag="KR257_002817"
     CDS             7135..8283
                     /locus_tag="KR257_002817"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423769.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="class I SAM-dependent RNA methyltransferase"
                     /protein_id="HBH0031497.1"
                     /translation="MKNYTLISPCFFGMEKMLAREITNLGYEIIKTEDGRITYKTDEF
                     GIAKSNMWLRCAERVHLKIAEFEAKSFDELFENTKRINWSRYIPYGAQFPISKASSIK
                     SKLYSTPDVQAIVKKAIVESLKKSYLEDGLLKEDKEKYPIFVFIHKDKVTISIDTTGD
                     ALHKRGYREKANKAPIRETLAAGLIYLTPWKAGRVLVDPMCGSGTILIEAAMIGINMA
                     PGLNREFISEKWRTLDKKIWWDVRKDAFNKIDNESKFKIYGYDIDEESIDIARENAEI
                     AGVDEYIEFNVGDATQFKSEDEFGFIITNPPYGERLEDKDSVKQLYKELGYAFRKLKN
                     WSYYLITSYEDFEYEFGQKADKKRKLYNGMLKTNFFQYPGPKPPRNNK"
     gene            8419..9807
                     /locus_tag="KR257_002818"
     CDS             8419..9807
                     /locus_tag="KR257_002818"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423771.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0031498.1"
                     /translation="MKVLKLITVVALMMLFVTGCNIKTESPEQLAKIPDYDDTKKVLY
                     DGIDQLLKPDSSMILPSNTKEVGKINKVDLNSDGIDELVVFEQKEDLSNNVSQVGFVT
                     LSYNGEKYVLGDHFLENGESIEYANFYDLDSDGYKEVILLVKSKDKTNMHIYKVVDNE
                     ITKIYDLDASWLQNKEDFNDMKVKIGYIDGDDKLDILMLHLNNKTNEMFASVANFDGK
                     MKIKDSVKFENVKNLSELYITLGNVASSVGNSSAAIKGIVLDIPILKDNNYITQILYM
                     KDGKINKAFSDYDKTITKSYYIPVDDIDKDKIIEIPIVAGSTGNNKNTYSSKSSATIS
                     WYRWNGKEGADSSLIFTSQIYYNYKYNFKLFIPNNLFDKILVEQEFVGEKAVFKFYYF
                     DYSDRKNLFNIVVESKNKLEDRKNTGTQNSIVLQESDEYTFLLVVNNANEMDKLDMTI
                     DVLKEYFSLIYG"
     gene            9836..10534
                     /locus_tag="KR257_002819"
     CDS             9836..10534
                     /locus_tag="KR257_002819"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889742.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HBH0031499.1"
                     /translation="MKEKILILEDEIGIRSFVSINLKREGYEIVEAGTGREAIEKMTT
                     EKDITIALLDVMLPDISGIEVCKFIRENFDQVGIIMLTAKAQEDDKIEGFISGADDYI
                     IKPFSIKELLVRVSALLRRVAKDDSSVKSSEIVSPPFILDIDKRKLFKNGKEIELTPT
                     EFSIVKYLISNAKQSLSRDQILDEVWGTNYLYDFKIVDVNIRRIRNKIEDDPSKPKYI
                     QTIWGYGYCFRKEE"
     gene            10537..11970
                     /locus_tag="KR257_002820"
     CDS             10537..11970
                     /locus_tag="KR257_002820"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423775.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HAMP domain-containing histidine kinase"
                     /protein_id="HBH0031500.1"
                     /translation="MLHFEGLRKKVIKNYFIIIIIMVTLFEGLFMFYIQNYYYDSVKQ
                     LLESEIKYADEYNAITMETTSFEKKVKNIFDKQPLTKNSEFGISIIDKDKNIILDQYG
                     FKSKEKANYEDVNNALKDIKTKNLTPYTYRIPDTGEHVMSISLPLKVNNIIEGVVRYT
                     VSLDAIDNAILKQATWLILAGIFILIIAILISLKFAETLIKPLRELKKFANELAVGNY
                     NIKLEKMKIVDDEIGDLAQTFEHMAHEIDKSEKLKEEFISSVSHELRTPLTSIKGWSE
                     TLGYESITREELDLGLGIIQDETERLIKLVEELLDFSRLSSDRIKLHVDIVDVEGLIV
                     GVVNQLKVKAAEKDISLLFEFENEFIENIQGDKNRLRQVLINLIQNSFKFTSQGGYIK
                     VVASQDEEITTISVEDNGSGIEKQNLNKVLDKFFQEDYNKAGSGLGLAISNEIVKLHG
                     GRMKIESEKNVGTKITFNIKNKFAKQA"
     gene            11992..12729
                     /gene="truA"
                     /locus_tag="KR257_002821"
     CDS             11992..12729
                     /gene="truA"
                     /locus_tag="KR257_002821"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011010156.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA pseudouridine(38-40) synthase TruA"
                     /protein_id="HBH0031501.1"
                     /translation="MRNIKMIVAYDGSRYKGYQKLGDNNMTIQEKLENVLSKMTNETV
                     EIIGSGRTDMGAHARGQVVNFRTNCMDSLDKIQKYLYEYLPEDIVVKTVEEVDERFHS
                     RYNVKSKTYMYKIDNNKYHNPFIRKYATHVSKKLDLDRMRKASEYLVGEHDFTSFASS
                     KSKKKSNVREIYSINIKEDDNVIEIYVEGNGFLYNMVRIIVGALIDVGLKRRAPQDIK
                     YMLESKDRCQSSDTAPAKGLCLWKVTY"
     misc_binding    12840..13047
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00230"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="T-box leader; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /bound_moiety="tRNA"
                     /db_xref="RFAM:RF00230"
     gene            13300..14499
                     /locus_tag="KR257_002822"
     CDS             13300..14499
                     /locus_tag="KR257_002822"
                     /EC_number="6.3.4.5"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896935.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="argininosuccinate synthase"
                     /protein_id="HBH0031502.1"
                     /translation="MKEKVVLAYSGGLDTSIIIPWLKENYEDIDVIAVCGNVGQEDKM
                     EDVYEKALQSGASKAYVDDISEEFVTETIFKAVKAEAKYEGKYLLGTSLARPIIAKKL
                     VEVAHKEGAKYICHGCTGKGNDQVRFEATIAALDPTIKVIAPWRIWDIKSREDAIDYA
                     EKHNIKVTATKAKIYSVDANLWHVSTEGGDIEHLENEHKKDVYKQCVDPEDACDVAEY
                     VEVYFEKGVPKKVNGEELSPVALIHKLNELGCKHGIGVIDIVENRLVGMKSRGIYETP
                     GGTILYEAHNILESATLDKDTLHFKQMVSYKYGELIYNGLWYCKLRESIDAFMEQTQD
                     NVTGTVKVKLYKGNIKPAGIFTENALYDEGISSFGNSELYDHKDAEGFINLFTLPLKI
                     RAMKAGK"
     gene            14746..15792
                     /locus_tag="KR257_002823"
     CDS             14746..15792
                     /locus_tag="KR257_002823"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889743.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4872 domain-containing protein"
                     /protein_id="HBH0031503.1"
                     /translation="MRKIIEIKHHSHDYECMWNGIEDLYINKTGEYLPNDFFFLLSGF
                     GSFCYMKTNKADLKRMVALGDGRTKQMYKFLAPIVGFEYKHHEFKKYEQALKKAKSEI
                     DDGYPVILGALDMYYLPYYKKLYHKEHIPFHYILMVGYDDEGIYLYDCGRTELLHLSY
                     DKLRESMNCNSPGLSKENTICTIRMNTSKNKYNIAREAIAIKRDMFLNPPKGFLGYKG
                     FEKFIKELPQWNTELDKDDYDKILTNMVMFFGTVPTIPNAIKGIKEPDTVQFKGGFDK
                     MSRMLNSIGEEYKNNSFIQVADIFDKTAIIIEKISNIIIDYLTQTCDDTEQLPLLFSE
                     VLEHMKTGYLILDV"
     gene            15900..17063
                     /locus_tag="KR257_002824"
     CDS             15900..17063
                     /locus_tag="KR257_002824"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728612.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MerR family transcriptional regulator"
                     /protein_id="HBH0031504.1"
                     /translation="MRTVKQVSDLTGISVRALHYYDEIGLLKPNKITDAGYRLYDDES
                     IKTLQQILFFKEIDIPLREVKEIMSSQYFDKVEALKNQKKLLILKRKRLDELIELINQ
                     TLRGEGNIDFKEFDMSEYFNVLEEFKREHRNKVIKIYGSVEKYNEYIERVKSNEEKIA
                     KMAIKQYGTIEKFAKAIKTNFSSDILNLGEKFDRYKNDCLKEKHPKLKELYRKLVEDL
                     SRNPSSTDLQEIAKAITDISKKDYEIFSMDTGDDNWYYMVQNYLVNPMWIEEVDKKYG
                     SGAGKFIGQVLKTYLRDRKPKINTLYEKLVEDLSRDCSSREVQSIVEEIDNEMKRSNE
                     FYKIDNGERYFDYMSELYLQDSNYIKVTDKNYGDGASKFIGEAFKIYFDNNNC"
     gene            complement(17152..17532)
                     /locus_tag="KR257_002825"
     CDS             complement(17152..17532)
                     /locus_tag="KR257_002825"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003439516.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4363 family protein"
                     /protein_id="HBH0031505.1"
                     /translation="MKSTTFVILWTILFVLFGFYVNNKLYDFTEGYKDNISVLEKSIE
                     NEDWEKAQKEADSISTSWNKEKNHWYKVLNHEYFDEIGLRFNILDKAIYTENKLKSLE
                     EVESIKTYLGNIIESVKFDVNYIF"
     gene            complement(17535..18194)
                     /locus_tag="KR257_002826"
     CDS             complement(17535..18194)
                     /locus_tag="KR257_002826"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430290.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF421 domain-containing protein"
                     /protein_id="HBH0031506.1"
                     /translation="MTVVLIRSIILYITVLIALRVMGKGEIAEMNCFDLVITLLIAEV
                     ASVPMENNNIPIINGVAAISGLVIMQTLISFLSLKSRKLSSFLSGKPSVLIDKGKIVY
                     KELKKERISIDELLEQLRIQGYFNLKDVQYAILETDGNLSVVPASSYNSTPPRAFNHL
                     PIPLILDGRIINKNLDIAQKDTNWLMGILKSNHIETFKDVLICVLDENDKIFIQNKKG
                     D"
     gene            complement(18300..19274)
                     /locus_tag="KR257_002827"
     CDS             complement(18300..19274)
                     /locus_tag="KR257_002827"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003433616.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="exonuclease domain-containing protein"
                     /protein_id="HBH0031507.1"
                     /translation="MKYKLFIDFEFNILDDNKNKPKEYNGAELISIGGVLVDNEFNTI
                     DNYYSLVKPKYNKILSNKCKNLTKLNQLDINNAPNLLYVMDDFYKWFCKFDDVTIYNW
                     GDFDITGLLTSFRVYKYTGKCLELFNMMIDIQPFISQHITYNNRILSKQISLLNMKKI
                     FSVEGDIKHNSLSDAVDLMNVCKCFFFNSPKNIDILEELYNKLPALKTPLYYIPYFED
                     ENFELKFDRTPEDIIIYLKQILTILNISKKEIYFKKRSVLVNNSKIINFKNLSSSFKL
                     IKLNEFEEYPDFILKLGDKKSFVESVIKINKSNRKSIKNLILKLSKKP"
     gene            complement(19314..19661)
                     /locus_tag="KR257_002828"
     CDS             complement(19314..19661)
                     /locus_tag="KR257_002828"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003433614.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0031508.1"
                     /translation="MLNLKEIREEIIKKYIGDSLISELTEELKNILITDLQSNPFKSN
                     IELSIIPANIEIFKKIENILIDSKVNLKMGWERILINYILKDLFELNYEINKSCNEPL
                     MFRVIISIDSYDA"
     gene            complement(19879..20835)
                     /locus_tag="KR257_002829"
     CDS             complement(19879..20835)
                     /locus_tag="KR257_002829"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902770.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="L-threonine 3-dehydrogenase"
                     /protein_id="HBH0031509.1"
                     /translation="MKKILITGALGQIGSELTIKLRNEYGEQNVIASSRRVKEGNPVC
                     ESGIFEILDVTDKNRFFEIAKKYDVDTIIHLASLLSAVAESKPLEAWNLNMNGLINGL
                     EIAKELDCKFFTPSSIAAFGENSPKNMTPQDTLQRPNTMYGVTKVSGELLCDYYHSKF
                     GVDTRGVRFPGLISYVTPPGGGTTDYAVDIYYEALKNKRYKSYIAEGTKMDMMYMPDA
                     LQSIVDLIEAPADKLIHRNAFNITAMSFSPEEIADSIKKYIPDFVIEYDVDPVRQSIA
                     DSWPNSLDSSSAVKEWNFKFSYDLDKMTKDMLEKLSEKGIGK"
     gene            21278..21646
                     /locus_tag="KR257_002830"
     CDS             21278..21646
                     /locus_tag="KR257_002830"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423793.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="C-GCAxxG-C-C family protein"
                     /protein_id="HBH0031510.1"
                     /translation="MTRPSIYHSQGYTCAEALIKSYNEEHNTDIPISIGSGMGVGMNV
                     GSVCGAVNAAVVIIGYLNGRNSNLDENIARKYSRELLNRVRNKYSSEICVSLKKNKVT
                     CEEIINFTYDALNDMLKNQK"
BASE COUNT         8649 a         2220 c         3604 g         7356 t
ORIGIN      
        1 attatgatat aattacaata aagtatgtaa taatctgtag aaatttcaag ctagttatct
       61 aagttttcgg ataactaaat ctaaacggaa tacataatgt attaaataaa tgatgatact
      121 aaaatgatac tatttttata gaaatttatt gaggtatata attaatgaaa ataatatatt
      181 aaattatata aattaaatta tataaattaa attatataat atattgagtt ttacataaaa
      241 gcaaaggtgg gaataaaaat gaaagaaatt gctgatgcta taacatcaga gtatttaagc
      301 tatggtatca atgaagatat tagtatctat gaaggtagat tttgcatata tttagataaa
      361 aaatatagat gtaatgggaa aatttattat aaaatgacac ctccaatatc tataagtttt
      421 aaagcagaca taggttgtgt tgaagagata gacaatgaag atgacaattt agctttagat
      481 tatgataatg ctattcttga agttcatgga tataaaatta tttctataac aataaatact
      541 ttaagtgaat ttagtgtaga aggttatatc aatgatgact gcataaaatc taagaactcc
      601 tatgttgaat atgtagattt taatataata aacttagata aaatacctgg aaaactcatt
      661 aaatacaatg ataaggtata cgcaggtaga attgaatttg atataaatga ttatgttgta
      721 actatagaca agcgatatga ttatagaaaa gaattaaaat cagaattaaa gtctaaatct
      781 ggagcaataa taactcatat aggtaggatt agaagaaaag atggtagaat ttttagaaca
      841 aataatacaa taaatctttt agataggata tcaacagctt tgagttttat gtgtggaaga
      901 tatgtagggt tttgtttggc caaagggtat agaagtggta atgaagttta tagaatatgg
      961 aatgaaaatc aaatatctcc ttttagatat gtaccaacat ggtcagatac actttcaaat
     1021 tattataata tggaaaaata tataagcctt atgtgtaaaa agctagaaga tttttattat
     1081 ggttctgcta taaagagtgt tgttgattgg tacatagaat ctcttggaag tgctaccatg
     1141 gaaaacaata taatatctgt acaaattgca cttgaaactt tgtcatatgt aattctagtg
     1201 gaacaaaata agatacttac agatgaagta tttgactgta atttggcatc taaaaatata
     1261 agactcttac ttgatacatg taagatacca tatggtaaac atgaattaaa tatatttgat
     1321 aatataataa aaaataaatt tgatgatgga gtggatttag ttatttattt aagaaatagc
     1381 atagttcatc caagtagaaa gactcataga gctgtgttag aggttgaaga tatttggaat
     1441 ataatttcaa taggaacgag atatattgaa cttgttttac tctttatttt aggttataga
     1501 ggagaatatt caaacagatt agtagaaaga tgttatggtg aagtggaagt tgtaccttgg
     1561 aactagattt ttatatttat tttaaaatat atattgacat atattgcctt atgctataaa
     1621 atcaatatca taataataat tcagaataac attaaatgct aagaaaagaa atagtaaaag
     1681 tagttaatct taaacagaga gtttccgatt ggtgagagga gcaatagatt ttactttgaa
     1741 cacatctttg agcaggactc tgaaagagta gaaatacttt attaggagat ttccggaatc
     1801 cttgcacccg ttatagtgct agagtataat aattttattg tacttaaaga ggttagtgtc
     1861 gtgaggcatt aatgaacaga ggtggaacca cgagagttaa ctcccgtcct ctagcagaag
     1921 ctagaggcgg gagtttttta atataatttt ttaagcgcgc agagaattat attgcaatag
     1981 atacactttt taaaaaataa tcaaaatatt ttaaaaatta aaaggcgagg gagaatatta
     2041 tgaaaaatat attaaaaaaa gtaggaatat ttacaattat gttaggttta ttaggtggag
     2101 ttgtaggttg ttcaaaacca gataatgaaa aagataagga tgcttcaaag gaatctaaaa
     2161 aagaagtagt tgtagggttt gataatacgt ttgtaccaat gggattttta gatgaaaagg
     2221 gagatacagt aggatttgac gtagacttag ctaaagaaac atttaaaaga cttggaatgg
     2281 aagttaagtt tcagcctata gattggtcaa tgaaagaaac tgaattaaat gattcaaaaa
     2341 ctgtagatgt attatggaat ggatattcta taacagacga aagaaagaaa atagtatcat
     2401 atacagaacc atatttacaa aataagcaga taatagttac tctaagtgac tcaaaaataa
     2461 attcaaaagc tgatttaaaa gataaagaag ttggaacaca acaaggttca acagcacttg
     2521 atgcagtgga aaaggataaa gattttatga atagcttaaa aggtggagca ccagttcttt
     2581 atgatactta tgataaagca cttagagatt tagagatagg tagaactagt gcagttgttg
     2641 gtgatgaagt tttaattaga tactatatgg gacaaaaggg tgaagacaaa tacaaggtat
     2701 taaaagacga ttttggatta gaagattatg ttgtagcaac ttctaaagaa aatccagaac
     2761 tttgtgagaa aataaatgaa acattaaaag aaatgaaaaa agatggaact tttgacaaga
     2821 tttatgataa gtggtttaaa tagaagataa gttagctgtt aagaaggggg cactaaaggc
     2881 atgttacaag gtttagagat agttatagca atgttttgta taacattgat agtatcaatt
     2941 ccattgggga ttggagttgc atttttaaga ttatcaaaga ataaattagt aagtggtatt
     3001 acacaatgtt atatattgat aatgagaggt acacctttac ttttgcaaat gatagtcata
     3061 ttttacggat tacctctttt aggaattgta tttgacagat ttacagctgg agtagtagct
     3121 ttcttcttaa attatgcagc atattttgca gaaatattta gaggtggaat acagtcaatc
     3181 gatagaggac aatatgaagc ttcaaaagta ctaggatttg ataagtttac tatgtataag
     3241 agagtaatct ttccacaagt ttttaaaaga atactagcac ctatttcaaa tgaagtaatc
     3301 acattagtaa aagatacatc tttagtatat atattaggat taaatgatat tttaagaata
     3361 tctcaaatag caatgaacag ggaagcaagt ctgttaccat tatttgaggc aggagcgata
     3421 tatcttatat ttgtagctat acttactaag ggatttgaat tacttgaaaa aaaatattct
     3481 tattatagat aaagttacaa tattatagga ggaggttttt tatatgttga aaatcaaaaa
     3541 cttaaataaa tcatttaaaa aaaatagagt acttaaagat atttcttttg agttagaaga
     3601 aggtcagatt ggagttttac ttggtaagtc tggtgcagga aagaccacaa tattaaggtg
     3661 tataaatggt cttgaagaat ttgatagtgg agagattata atagataatg aggtaataaa
     3721 aaataagaga gatatggcaa aaatacgagg aaaaataggt atggtttttc aaaatttcaa
     3781 cttatttcct catatgacag tccttgaaaa tataattgaa tccccagtta atgtttttaa
     3841 agttcctaga aaagaggctg aagagagggc tagagaactt ttaagattag ttgatttaga
     3901 agataaatta aattcttatc catttgaatt gtcaggagga cagcaacaga gagttgctat
     3961 agctaggtca tgtgcattga tgccaaaagt cctttgtttt gatgaaccta cttctgcact
     4021 tgatattgat actattcaaa gagtagtcaa tataatgaac agacttaaag acaaaggtat
     4081 gacaatatta ataattacac atgatgttgt cttctcaaat aatgttgcag ataaaattat
     4141 aagtataaaa gatggtatag tagaaaatgt tcaaataaaa gaaaaaattg tttagagttt
     4201 tataaatata aactagggta gaattttata atataaataa agggcaagta aaatcaaata
     4261 tactatgccc ttttgttatc tcaaaattta atcttatatt ttatgtttaa gttacattat
     4321 aatttataat aaaaataaaa ggactattta aatatataat gtgaataatg tttaataatt
     4381 tgaaatatga taatttttta tgttgaaagc ttataatgat tatgatataa attggttata
     4441 gtatacaatt tatgggtata acaataaaaa attagaaagg aatttttata aaatgattaa
     4501 attatatgga tatacaaaat gctctactgt taaaaaagct aaaaattggc ttaaggaaaa
     4561 taatttagaa tttgaagata tagatatggt tcaaaaccct cctagtaaag aggagttaaa
     4621 atcaatttat aagactagtg gatatgatat aaagaaattt tttaatacaa gtggtatgaa
     4681 atatagagaa ttgggtctta aagatattgt aaaaactgaa tctgatgata aacttttaga
     4741 aatattggta agtgatggta tgcttattaa aagaccatta cttttggatg gtaaaaatgt
     4801 attattgggt tttaaagaag atgtatggaa aagtactttg ctaaaagaag attaggaaga
     4861 gataggtgtg ttgattaaaa ttattaatta atacacctat aaatttatgt attaaatcta
     4921 atctttataa atattaatta gcaaattcaa atcaaaaaaa ttcatatcaa caaacatatt
     4981 acttcttatt acaaattata tcatatgttt tatattaaaa tattataata ttacaacgaa
     5041 ttgttacaaa attacttatt attaaccatg aacatttgtt ttgtgctatc atatttatat
     5101 aagggaattg tcataaaaaa tatcttgttc atacagtttt atatagaaaa aagaaatgaa
     5161 tcttttcttt atataagtat attttgtaaa ttgcctctat atttatagtt taaataatag
     5221 tggtattaaa aatctgacaa caaaaataaa actttcaaaa aattaaatct aaaaagaata
     5281 ggagataaat atgagtattg aagatttata tgattttgaa tgtgttcctt tgaacaatga
     5341 gattgatatt gatgttttat ttgaaaagat gatagaagat ggaaaagaaa aagaatatac
     5401 accaattata gtcattgatg aaaaagtagg gctattaaga aaaaatatag atatgattac
     5461 taaagagtat ggttctcttg aaaactatag agagtattgt ttaacaaaat ataatgaaat
     5521 tgatgtaaat caattttttg attttaggaa gagtgagatt tcagaattat taaaggagct
     5581 aattgattta gaagatgatt tttatgatta taaacatttt agacccatta tgaatataga
     5641 tatatttcat gaatataaca aagtttacat agctaaaatt ccaacaatta aaccatatga
     5701 agtatttgca tacataccta ttggcggatt taatgattgt cctagagatg aagaacatat
     5761 agctattgca aaatattggt atgaaaagca tggaatcttt ccaatcgcaa ttggatgtga
     5821 tacagttcaa tattctgtaa aaaatttaac taaagatggt aaaaaatttg atgacttatg
     5881 tattgaatta gtattttatt gtgaggatat tattatacaa gggtatgaaa ccttaaaggc
     5941 tcttaaggat gtattaaaac gctctacaat agtgcttttt tggtgggatt gatattctat
     6001 catttagata gtattaaatt gttagtcacc aagaatccac ttgctttagt tatagggagt
     6061 gtgtcaaact aggtttttat acacagtgta gcatagtaat atgtttaaat tacaaaggtt
     6121 aaaaaaatac tttaatattt ttaatattat aattaataga tttaaggtaa ttataattta
     6181 taaaataaat actttatatg ttataatcat taagaatgta aaaaaataat atatagtttt
     6241 atagttcata tttttccaga tatggaggta aattttgtga aggaaaaaga aaaattagat
     6301 aaattaaaaa aaatgttact tgaattaggc agtgttgtag ttgcttattc tggtggagta
     6361 gatagtaatt ttttgcttaa ggtcgcaaaa gatacattag gtgaaaatgt tatagctgtg
     6421 actattcatg caatgatgca ttcaagtagg gaaattgaag aggctaaaca atatactcaa
     6481 aattttggtg ttaaacatat catattaaat atagaaaact ttgatttaaa agaatttaaa
     6541 gaaaatggtg ttgatagatg ttatcattgt aaaaaatata tattctctaa aataaaagag
     6601 gtagcaaaag aacataatat aaagtacata gtagatggaa caaatataga tgatttagga
     6661 gactatagac ctgggcttaa ggcattgagt gaattaggag taattagtcc attaaaagat
     6721 agtagtttaa aaaaagaaga aattaggtcg ctttcaaaaa cattaggatt aaatactttt
     6781 aataaaccat catttgcatg tcttgcgagt aggatacctt atggagttga aataacagat
     6841 gaaaatttaa gaatagtaga aaagagtgaa gaatatctat ccaatttagg tttttctcaa
     6901 tttagagtga gaatgcatgg agatatagct agaatagaag ttggacagga agagctaggt
     6961 aaattttttg aaaataacaa ttttaataaa gttgatacta aattaaaaat atttggcttt
     7021 aaatatgtta cactagatat gtcaggatat aaaatgggaa gcatgaattt aaatgtgtag
     7081 attattttaa aaataaataa gttttatagt taatataagg aaacaggagg ttttatgaaa
     7141 aattatacgt taatatcgcc atgttttttt ggaatggaaa aaatgctggc tagagagatt
     7201 actaatttag gatatgaaat aataaaaaca gaagatggaa gaataacata taaaactgat
     7261 gagtttggaa tagcaaagtc aaacatgtgg ttgagatgtg ctgaaagagt acatcttaaa
     7321 attgctgaat ttgaggcaaa aagctttgat gaattatttg aaaatacaaa aagaataaac
     7381 tggtctagat atatacctta tggagctcaa tttcctatat caaaagcttc ctctataaaa
     7441 tcaaaattat acagtacacc agatgtacaa gccatagtaa aaaaggctat agtagaaagc
     7501 ttaaagaaaa gttatttgga ggatggtttg cttaaagaag ataaggagaa ataccctatt
     7561 tttgtattta tacacaaaga taaagtaacc atttctatag atacaacagg agatgctttg
     7621 cataagagag gatatagaga aaaggcaaat aaagctccaa taagagagac tttagctgct
     7681 gggcttattt atttaactcc ctggaaagca ggtagagttt tagtagaccc tatgtgtggt
     7741 tctggtacta tattgattga agctgctatg attggtataa atatggcacc tggcttaaat
     7801 agagagttta tatcagaaaa gtggagaact cttgataaga aaatatggtg ggatgtaaga
     7861 aaagatgctt ttaataagat agataatgaa tctaaattta agatttatgg atatgatata
     7921 gatgaagaat ctatagatat agctagagaa aatgctgaaa tagcaggtgt agatgaatat
     7981 atagagttta atgtaggaga tgcaactcaa tttaaaagtg aagatgagtt tggatttata
     8041 atcactaatc ctccttacgg agaaagatta gaagataaag acagtgttaa acagttgtat
     8101 aaggagcttg gttatgcatt tagaaaatta aaaaattggt cgtattattt gataacttct
     8161 tatgaagact ttgaatatga gtttgggcaa aaagcagata aaaaaagaaa attgtataat
     8221 ggtatgttaa aaactaactt tttccaatat ccgggtccta agcctcctag aaataataaa
     8281 taagttttac atgatttatt tgtaaaatat aaaattttat taaaataagt aaaacattat
     8341 gatgccctga aacgtctaat tattgtgagg agatttttgt gaacaaattt aaagatttat
     8401 aggattagga ggagttaaat gaaagtgtta aagcttatta ctgtagtagc cctgatgatg
     8461 ttatttgtta ctggatgtaa tataaaaact gaatctccag aacaattagc gaagatacct
     8521 gactatgatg atacaaaaaa agtattgtat gatggtattg accagttact aaaaccagat
     8581 tcatctatga tattgccttc taatacaaaa gaagtaggaa aaataaataa ggtagattta
     8641 aacagcgatg gaattgatga attagtagta tttgaacaaa aagaagattt aagtaataat
     8701 gtgagtcagg tagggtttgt aaccttgagt tacaatggag aaaaatacgt acttggagac
     8761 cattttttag aaaatggcga atcaatagaa tatgctaatt tttatgattt ggactcagat
     8821 ggatataagg aagttatctt attggttaaa tccaaagaca aaacgaatat gcatatatat
     8881 aaagtagtag ataatgaaat aacaaaaata tatgacttgg atgcatcatg gcttcaaaat
     8941 aaagaagatt ttaatgacat gaaagtaaaa attggatata tagatggaga tgacaagtta
     9001 gacatattga tgcttcattt gaataataag actaatgaaa tgtttgcaag tgttgcaaat
     9061 tttgatggga aaatgaaaat caaagattct gttaagtttg aaaatgtaaa aaacttaagt
     9121 gaattatata taacattagg taatgttgct tcatctgttg gaaattcttc tgcagctata
     9181 aaaggtattg tacttgatat tcctatattg aaagataata actatattac gcagatactt
     9241 tatatgaaag atgggaaaat taacaaagct tttagtgatt atgataaaac tattactaaa
     9301 tcttattata tacctgtaga tgatattgac aaagataaga ttatagaaat acctatagtt
     9361 gcaggcagta caggtaataa taaaaatact tatagttcta aatcatctgc aactataagt
     9421 tggtatagat ggaatggaaa agaaggtgct gactcaagtt taatatttac aagtcagata
     9481 tattataatt ataaatataa ttttaaatta tttattccaa ataatttatt tgataaaata
     9541 cttgttgaac aggaatttgt tggagaaaaa gcagtattta aattttacta ttttgactat
     9601 tcagaccgta agaatttatt taatatagta gtagagagta aaaataaact tgaagataga
     9661 aaaaatacag gtactcaaaa ttctattgta cttcaagaga gcgatgaata tactttctta
     9721 ctagttgtaa acaatgcaaa tgaaatggat aagctagata tgactataga cgtattaaaa
     9781 gaatatttct cattaatata tggttaatat tatactcaat tggaggtttt attttatgaa
     9841 ggaaaagata cttatactag aagatgaaat tggtattaga agttttgtta gtataaactt
     9901 aaaaagggaa ggctatgaaa tagttgaggc aggtactgga agagaagcta tagaaaaaat
     9961 gacaacagaa aaggatatta caatagctct tttagatgta atgcttccag atataagtgg
    10021 tatagaagta tgtaaattta taagggagaa ttttgaccaa gtaggtataa taatgcttac
    10081 tgctaaagct caagaagatg ataaaataga aggatttatc tcaggagcag atgattacat
    10141 cataaaacca tttagtataa aagagctttt agtcagagtt tctgctcttc ttagaagagt
    10201 agcaaaggat gattcaagtg ttaagtcgag tgagatagtt tctccaccat ttatacttga
    10261 tatagacaaa agaaaattat ttaaaaatgg aaaggaaatt gagcttacac caactgaatt
    10321 ttcaatagtg aaatatctaa tatcaaatgc taagcagtcg ttaagtagag accagatatt
    10381 agacgaagta tggggaacta actatttata tgattttaaa atagtagatg taaatataag
    10441 aaggataaga aataaaatag aagatgaccc atcaaaacca aaatatatac aaactatttg
    10501 gggttatgga tactgtttta gaaaggaaga ataatagtgt tacattttga aggtctgaga
    10561 aaaaaagtaa taaaaaacta ttttataata attattataa tggttactct gtttgaagga
    10621 ttgttcatgt tttacataca aaactactat tatgattctg tcaaacagct acttgaatct
    10681 gaaataaaat atgctgatga atataatgct attacaatgg aaactacaag ttttgagaaa
    10741 aaagtaaaaa atatatttga taaacaaccc ttaactaaaa attcagaatt tggaatttca
    10801 ataatagata aagataaaaa tattatatta gaccaatatg gttttaaaag taaagaaaaa
    10861 gcaaactatg aagatgttaa caatgcatta aaagatataa aaactaaaaa tttaacacct
    10921 tatacttata gaataccaga tacaggggag catgttatga gtatctcctt accacttaag
    10981 gtaaataata taatagaagg tgttgttaga tatacagtat cattagatgc tattgataat
    11041 gcaatattaa agcaagctac atggcttata ttagcaggaa tatttatact tattatagct
    11101 atactaataa gtcttaaatt tgctgagact cttataaaac cattacgaga gctaaagaaa
    11161 tttgcaaatg aattggctgt aggaaattat aatataaaat tagaaaagat gaagattgta
    11221 gatgatgaaa ttggtgattt agcacagaca tttgaacaca tggcacatga gattgacaaa
    11281 agtgaaaaat taaaagagga atttatatca tctgtatctc atgaactaag gactcctctt
    11341 acatctataa aggggtggag tgaaacctta ggttatgaaa gtataacaag agaagaacta
    11401 gacttaggtt taggcattat acaagatgaa acagaaagac ttataaaact agttgaagaa
    11461 ttattagact tttcaaggct ttcttcagac aggataaaac ttcatgttga tatagttgat
    11521 gttgaaggtt taattgtagg tgttgtaaat caacttaaag ttaaagcagc tgaaaaagat
    11581 atatcacttt tatttgaatt tgaaaatgaa tttatagaga acattcaagg agataaaaat
    11641 agattaagac aggttctcat aaatttaata caaaattcat ttaaatttac gagtcaaggt
    11701 ggttacataa aagttgtagc ttctcaagat gaagagataa caaccatatc agtagaggat
    11761 aatggttcag gtatagaaaa gcaaaattta aataaagtgt tagataaatt tttccaagaa
    11821 gattataata aggctggtag tggattagga ctagcaatta gtaatgaaat tgtaaaactt
    11881 catggtggaa gaatgaaaat agaaagtgaa aagaatgttg gaacaaaaat aacttttaat
    11941 ataaaaaata aatttgctaa acaagcataa attcttagaa agaggattaa gatgagaaac
    12001 ataaaaatga tagtagcata cgatggttca agatataaag gatatcaaaa attaggtgac
    12061 aataatatga ctattcaaga aaaacttgaa aatgttttaa gtaaaatgac taatgaaaca
    12121 gtggagataa taggttctgg aagaactgat atgggagctc atgcaagagg acaagtggta
    12181 aattttagaa ctaattgtat ggattctttg gataaaattc aaaaatattt atatgaatat
    12241 ttaccagaag atatagttgt aaaaactgtt gaagaagttg atgaaagatt tcattcaaga
    12301 tacaatgtaa aatcaaagac ttatatgtat aaaattgaca ataataagta tcataatcct
    12361 tttataagaa aatatgctac tcatgtaagt aaaaaattag atttagatag aatgagaaaa
    12421 gcaagtgagt atttagtagg agaacatgat tttactagtt ttgcttcttc taaatctaag
    12481 aaaaaatcaa atgtaagaga aatttattct ataaatataa aagaagatga taatgttata
    12541 gaaatatatg tagaaggaaa tggatttttg tataacatgg taaggataat agtaggtgct
    12601 ttgatagatg ttggtctaaa aagaagagct ccacaagata ttaagtatat gcttgaatca
    12661 aaagatagat gtcaatcatc agatactgca ccagctaaag gactatgtct ttggaaagta
    12721 acatattaat caattatata aaactctctt taaaataaaa ataaaataaa ttatatagtt
    12781 gacataaatg gaaaaataaa ctattatata ttttataaga gagatataaa actttatatt
    12841 taaatcctgt gagaaagaga gtaacttcta tgtgttttat agagagctga ggatggtgga
    12901 agcttggcaa ataagtatta gtgaaaagaa ctttggagga tactaattga atttagtatg
    12961 ttagtaggta atctcgcctt aagagaaaga gtggataagt ttatcttatc aattagagtg
    13021 gtaacgcgga tatatttcgt ctcttggttt ttccaagagg cgttttttaa tatatttaat
    13081 tattagtgtt tatctggtat gttgaacatt tactaattga ttagctaagt ttatcaataa
    13141 gagtggtacc gcggatattt cgcctcttag tattttaaaa tactaagggg tttttttagt
    13201 attaaaatga ttttatgtga gtctaaattc tcagagtcat tcaatattaa gaatttctat
    13261 aaaataaaaa ttataattta agattgggag gaattaaaaa tgaaggaaaa agtagtatta
    13321 gcatattcag gaggacttga cacatcaatc ataatacctt ggttaaagga aaattatgaa
    13381 gatatagatg ttatagctgt ttgtggaaat gtaggtcagg aagataaaat ggaagatgta
    13441 tatgaaaaag ctttacaaag tggagcatca aaggcatatg tggatgatat aagtgaagaa
    13501 tttgtaactg aaactatatt taaagctgta aaagcagagg ctaaatatga aggaaaatac
    13561 ttattaggaa cttctttagc aagacctata atagctaaaa aattagttga agttgctcat
    13621 aaagaaggtg caaaatatat atgccatgga tgtacaggaa aaggtaatga ccaagttaga
    13681 tttgaagcta caattgcagc tcttgaccca actataaaag ttattgcacc ttggagaatt
    13741 tgggatataa aatcaagaga agatgctata gactatgctg aaaaacataa tataaaggta
    13801 acagcaacta aagctaaaat atattcagta gatgccaacc tttggcatgt ttcaacagaa
    13861 ggtggagata tagagcacct agaaaatgaa cataaaaaag atgtttataa acaatgtgta
    13921 gacccagaag atgcatgtga tgtagctgaa tatgtagaag tttactttga aaaaggtgta
    13981 cctaaaaagg taaatggcga agaattatct ccagttgcac tgattcataa gttaaatgag
    14041 ttgggttgta aacatggaat tggtgttata gatatagttg agaatagact tgttggtatg
    14101 aaatcaagag gtatatatga gactccagga ggaacaatcc tttatgaagc acataatatt
    14161 ttagaaagtg ctactttaga caaagataca ttacatttca aacaaatggt atcttataaa
    14221 tacggagaac ttatttacaa tggactatgg tattgtaaat taagagaatc tatagatgca
    14281 tttatggaac aaactcaaga taatgttaca ggaacagtaa aagttaaact ttacaaagga
    14341 aatataaaac ctgctggaat atttactgaa aatgctcttt atgatgaagg aatatcttct
    14401 tttggaaata gtgaacttta tgaccacaaa gatgcagaag gatttattaa tttattcact
    14461 ttaccattaa aaatcagagc tatgaaagct ggaaaataat aaaataaatt atttaagagt
    14521 gtataaaaac gatttttagg tttttatatg ctcttttttt atttgaattt attaaattat
    14581 acagtaaata gtataaaaaa atatattata gttccaaatg gcttaataat gtgaaaatat
    14641 aagacctaaa atataaattt tataaataca atagttattg actctctcat tgtaagaggg
    14701 tttatactga atctaatgaa aatttatagt gaggagatag attatatgag aaaaataatt
    14761 gaaattaaac atcattcaca tgattatgag tgtatgtgga atggtataga agatttatat
    14821 ataaataaaa ccggtgaata ccttccaaac gattttttct ttttactgtc aggttttggt
    14881 tcattttgtt atatgaaaac aaataaagct gatttgaaaa gaatggtagc tttgggagat
    14941 ggaaggacaa aacagatgta taaattttta gcaccaattg ttggatttga atacaaacat
    15001 catgagttta aaaagtatga gcaagcatta aagaaagcaa aatctgaaat tgatgatgga
    15061 tatccagtta ttttaggagc tttagatatg tattatctac catattataa gaagctatat
    15121 cataaagaac atattccttt tcattatata ttaatggtag gatatgatga tgaaggaata
    15181 tatctgtatg attgtggtag aacagaatta ttacatcttt cttatgataa attacgtgaa
    15241 agcatgaatt gcaattcccc tggattaagc aaagaaaata ctatttgcac aataagaatg
    15301 aatacttcaa agaataaata taacattgct agagaagcta ttgctataaa gcgtgatatg
    15361 tttttaaatc cacctaaagg atttttggga tataaaggtt ttgaaaagtt tattaaagag
    15421 ttgccacagt ggaacactga attggataag gatgattatg ataagatttt gaccaatatg
    15481 gttatgtttt ttggaacagt accaacaatt ccaaatgcaa tcaaaggaat taaagaacca
    15541 gatactgttc aatttaaagg tggatttgat aaaatgagta gaatgctcaa cagtattggg
    15601 gaggaataca aaaacaactc ttttatacaa gtagctgata tttttgataa aactgctatt
    15661 ataattgaga aaatatccaa tattataata gattacttaa ctcaaacatg tgatgataca
    15721 gaacaacttc cgttattgtt ctctgaggtc ttagagcata tgaaaacagg atatttaatc
    15781 ttggatgtat aaaaaatata ttgttgaccc taacattacg taatagtgta atatgaaaat
    15841 atagcttaaa tatattagta ggtattgatg gctgtaaaat taaaatttga ggtgtggata
    15901 tgagaacagt gaaacaagtt tctgatttaa ctggaataag tgtgagggca ttacattatt
    15961 atgatgaaat aggtctttta aaaccaaata aaattacaga tgcaggatat agactttatg
    16021 atgatgaatc tattaaaact cttcaacaaa ttttattttt taaggagatt gatattcctt
    16081 taagagaggt taaggaaata atgtcaagcc aatattttga taaggttgaa gctctaaaaa
    16141 atcaaaaaaa attacttatt ttaaaacgaa agagactgga tgaattgata gagcttataa
    16201 atcaaactct aagaggagaa ggaaatattg attttaaaga gtttgatatg agcgagtatt
    16261 ttaatgtttt agaagaattt aaaagagagc ataggaataa ggtaattaaa atttatggta
    16321 gtgtagaaaa atacaatgaa tatatagaaa gagttaagtc taatgaagag aaaattgcta
    16381 aaatggctat aaaacaatat ggaactattg agaagtttgc taaagctata aaaacaaatt
    16441 ttagcagtga tatattgaat ttaggagaaa aatttgatag atataaaaat gattgtttaa
    16501 aagaaaaaca tccaaaatta aaagaattat atagaaagct tgtagaagat ttaagtagga
    16561 atccttcttc aacagacctt caagaaatag caaaagcgat aacagatata tctaaaaaag
    16621 attatgaaat tttctctatg gatactggtg atgacaactg gtattatatg gttcaaaatt
    16681 atctagtaaa tcctatgtgg atagaagaag tagataaaaa gtatggaagt ggagcaggaa
    16741 agtttattgg acaagtacta aagacttatc taagagatag aaaaccaaag ataaatacat
    16801 tgtatgaaaa acttgtagaa gatttgagta gagattgttc ttcaagggaa gttcaaagca
    16861 ttgttgaaga aatagacaat gaaatgaaaa gaagtaatga attttataaa atagacaatg
    16921 gtgaaagata ctttgattat atgtcagagc tttatttaca agattctaac tatataaaag
    16981 taactgataa gaattatggt gatggtgcat ctaagtttat tggagaagct tttaagattt
    17041 attttgataa taataattgt tgaaaatttg gaagtaaaaa atatgtaagt tttataaaag
    17101 cacaaaaata aggatgtaga ttagctccat ctatatcctt atttaaagtt attaaaatat
    17161 atagtttaca tcaaacttaa cactttcaat aatatttccc aaatatgttt ttatactttc
    17221 aacttcttct aaagatttta atttattttc agtataaatt gctttgtcca gaatattaaa
    17281 ccttaatcct atttcatcaa agtactcatg atttaaaact ttgtaccaat ggtttttttc
    17341 tttattccaa ctcgtagata ttgaatcagc ttctttttga gctttttccc aatcttcatt
    17401 ttctatagat ttttctaaaa cagatatatt gtctttatat ccttctgtaa aatcatatag
    17461 tttattgtta acgtaaaatc caaataatac aaataagata gtccatagta taacaaatgt
    17521 tgtagatttc aatattaatc acccttttta ttttgaataa atattttgtc attttcatct
    17581 aaaacacaaa taagaacatc tttaaaagtt tctatgtgat tagattttaa aatacccatt
    17641 aaccagttag tatctttttg agctatgtct agatttttat ttattattct accatccagt
    17701 ataagtggga taggtaaatg attaaaagct cttggaggag tactattgta gcttgatgct
    17761 ggtacaacac ttagattacc atcagtctcc aaaatagcat attgtacatc ttttaggtta
    17821 aagtatcctt gaatcctaag ttgttctaat aattcatcta tactaattct ttctttttta
    17881 agctctttat atacaatttt tcctttatct attaatacag aaggtttacc tgataaaaat
    17941 gaacttaatt ttctgctttt taatgataag aatgaaatta gagtctgcat gattacaagt
    18001 ccagatattg ctgcaacacc atttatgatt ggtatattat tattttccat tgggacagat
    18061 gcaacttctg caattaatag tgttataact aaatcaaaac agttcatttc agctatttca
    18121 ccttttccca tgactctaag tgcaattagc actgttatgt ataatataat acttcttatt
    18181 aatactactg tcatatctat caattactcc tttaaaaaat atttacactt agttagtata
    18241 tcctatataa aaaatttaat tcaaagtata aaaaacctta aataattgga ttcaactatt
    18301 taaggttttt ttgataattt taatattaaa ttttttatgg attttctgtt acttttattt
    18361 attttaataa cagattcaac aaaactcttt ttatctccta attttaagat aaaatcagga
    18421 tattcttcaa attcattgag ttttattaat ttgaaagaag aagatagatt tttaaagtta
    18481 ataattttag agttattcac taatacactt ctttttttaa aataaatttc ttttttactt
    18541 atatttagta tagttaatat ttgtttaaga tatattatta tatcttctgg agttctatca
    18601 aatttgagtt caaaattttc atcttcaaag tagggaatat aatataaagg tgttttgaga
    18661 gcaggtaatt tattatataa ttcttcaaga atatcgatat ttttagggga gttaaagaaa
    18721 aagcatttac atacattcat taaatccaca gcatctgaaa gtgagttatg tttaatatct
    18781 ccttctacag aaaaaatttt tttcatattc agtaaagata tttgcttaga taagattcta
    18841 ttattgtatg taatatgttg agatataaaa ggttgaatgt caatcatcat attaaataac
    18901 tctaagcatt tacctgtata tttatacact ctaaatgaag ttagaaggcc agttatatca
    18961 aaatcacccc aattatatat tgtaacatca tcaaatttac aaaaccattt ataaaaatca
    19021 tccataacat ataaaagatt aggagcatta ttgatatcta gttggttcaa tttggttaaa
    19081 tttttacatt tatttgaaag tattttattg tattttggct taactaaaga gtaataatta
    19141 tctattgtat taaattcgtt atcaactaaa actccaccaa tagaaattaa ttccgcacca
    19201 ttatattctt ttggtttatt tttattatca tctagtatat taaattcaaa gtctataaat
    19261 aacttgtatt tcataaatct aaagcacatc ctcaggtaaa ttatttattg agcctaagca
    19321 tcataagaat caatagatat aatgactcta aacatcaaag gttcattaca acttttattt
    19381 atttcataat ttaattcaaa taaatctttt aagatataat ttataagtat tctttcccaa
    19441 cccattttta aattaacttt agagtctatt aatatatttt ctatcttttt aaatatttct
    19501 atatttgctg gtattatact gagctcaata ttacttttaa acgggttaga ctgtaaatct
    19561 gttataagta tattttttaa ttcctctgta agttcagaaa ttaaactatc acctatgtat
    19621 ttttttatga tttcctctct aatttctttt aaatttagca atattagtac ctgctactta
    19681 catagtagct tttcctttcc ttttaatact attattcatt tttgaatctt atttagatat
    19741 attttaagat taaaagtctt tagctatata attttttacc catttttaac ttatattaac
    19801 atattacagg cttatatctc caccctgttt acattgagga tggagtatat tgcctatttt
    19861 gataaaaatg ataggttgct atttgcctat tcctttttct gataattttt ctaacatatc
    19921 tttggtcatt ttatctaaat cataactaaa cttaaagttc cattctttta ctgcactact
    19981 actgtctaga gagttaggcc aagaatcagc tatactttgt cttacagggt ctacatcata
    20041 ttctatcaca aaatcaggaa tatatttttt tatagaatca gctatttctt caggagaaaa
    20101 gctcatagca gtaatattaa aagcatttct atggatgagt ttatcagctg gagcttcgat
    20161 taaatccact attgattgaa gtgcatcagg catatacatc atatccattt ttgtaccttc
    20221 tgctatgtaa gatttatatc tcttattttt taatgcctca taatatatat caactgcata
    20281 atctgtagtt cctccaccag gaggcgtaac ataagaaata agacctggaa atctaacacc
    20341 tctagtgtct actccaaatt ttgagtgata ataatcacat agtaattctc cagaaacttt
    20401 agtcacacca tacatagtat taggtctttg taatgtatct tgaggagtca tattttttgg
    20461 agaattttca ccaaaagcag caattgaact aggtgtaaaa aatttacaat ccaattcttt
    20521 ggctatttca agaccattta ttaatccatt catatttaag ttccaagctt ctagaggttt
    20581 actttcagca actgcagaaa gtaaagatgc tagatgaatt atagtatcta catcatattt
    20641 ttttgcaatt tcaaaaaaac gattcttatc tgtaacatct aatatctcaa atataccaga
    20701 ttcacatact ggattacctt cttttactct ccttgaacta gcgattacat tttgttctcc
    20761 atactcattt ctaagcttta ttgttaattc tgaacctatt tgtcctaatg cacctgttat
    20821 aagtattttt ttcaatttta caacctccta agggtttaat ttatgtagta ctacttattt
    20881 ttattttagc aaatcttttg tttaaataca aagaattaaa gataataata tacgacttaa
    20941 ttgaatgaag tgcagtaagt gcgtaaaaat ttaaagctaa tatataatgg tctattgtat
    21001 aacaataaaa gagtagatta aattattata tatagattgt gtgactaagt cacagaaaat
    21061 agagctaatt taatatataa taaaagcatg tcaagtaaag ctttaaatta aagtaacttt
    21121 atataaaaag taatataaat tgataaaatt ataaatttat ttatagtgaa tataggttgg
    21181 attttataga tacaaaaata gtatatatga tatgtagacc attagcatgt ttaaagtagc
    21241 aaaacatata aaataaaatt tgaaaggaag tataaaaatg acaagaccat caatatatca
    21301 tagccaagga tacacttgtg cagaggcatt aataaagtct tataatgagg aacacaacac
    21361 agatatacca atctcaatag gaagtggtat gggggttgga atgaatgttg gaagtgtttg
    21421 tggagctgta aatgctgctg ttgttataat agggtattta aatgggcgaa atagtaattt
    21481 agatgaaaat atagcaagga agtattcaag agagctattg aatagagtaa gaaataaata
    21541 cagctcagaa atatgtgtat ctcttaaaaa aaataaagta acttgtgaag aaataataaa
    21601 tttcacatat gatgctctaa atgatatgct aaaaaatcaa aaataattct aagaaacaag
    21661 tattttacat tcgatagaat acttgttttt ttatgatatt tttaataagt attagtttat
    21721 tataattttt aaatcaattt tattatattt taattgaaat aatctacttt gaaaattact
    21781 aactgacaaa agaatatgat tatagtatag aaaaaatgta aattattta
//
LOCUS       DAEPID010000068        21591 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.068, whole genome shotgun sequence.
ACCESSION   DAEPID010000068 DAEPID010000000
VERSION     DAEPID010000068.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 21591)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 21591)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..21591
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.068"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            379..1083
                     /locus_tag="KR257_002831"
     CDS             379..1083
                     /locus_tag="KR257_002831"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888771.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HBH0031511.1"
                     /translation="MSKLIYIADDEDNIRNLVKTFLKNEGHDVMDFKTGDELLEQFNI
                     KECDLVILDIMMPGSSGFEVCTKLREKSTVPIIMLTARDTDIDYITGITLGSDDYFTK
                     PFSPMSLVMRVKSIFRRIEFEKKQNYDKYSNSIDMELKFGDVIINKKNKIVTSKNVNI
                     DLTPNEYNLLTYLFENIDRAISRDELLNKIWGYDIEVETRAADDTVKRLRKKILDTNI
                     LIETVWGFGFRLKEKS"
     gene            1085..2572
                     /locus_tag="KR257_002832"
     CDS             1085..2572
                     /locus_tag="KR257_002832"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003432175.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HAMP domain-containing histidine kinase"
                     /protein_id="HBH0031512.1"
                     /translation="MKNGNDKNRIGKIKSKFKLKFSKKNISIKTRILLSILCLIIIVF
                     MIILVSFNVFLDTYIKTTANEELTKSTEIVEHMDSNFRPIKPPQDDGKLPPKVLSNFM
                     RNVQDKVRMAETQSDADAMVVDSKYNLIFPTREDDFLKNVDEMELIRECIQNEKLDLN
                     SDANTRISTRNKDYYISTVKITSIYGEQDKYLILFIDISKTLNLAQKINIVLISVMCF
                     AGILAIFTAVILSEKIAKPIKELCEFAKKMGQGDFKRTYFDFSDKELVELSTVMNKSA
                     EYLDKYDNEQKIFFQNASHELRTPLMSIKGYAEAIKYNVIDSKHASDIILEESDRLSD
                     MVEDLLYISKIDNITKDFELVECDLREVLSNCGARQNVRAINKGIKFIYEFDEEMVLF
                     ECDEKNISKAFMNLIENALRYAKSEIKIVCKYNQKNIVVIIEDDGIGIKKEDLPHVFE
                     RFYKGVGGNHGIGLSIVKSIVNKHGGRIYVENGKKGAKFTILFKL"
     gene            2777..4390
                     /locus_tag="KR257_002833"
     CDS             2777..4390
                     /locus_tag="KR257_002833"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437032.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="diguanylate cyclase"
                     /protein_id="HBH0031513.1"
                     /translation="MKEQLIFNITNLVTVVFEAFVIHMFLSDFLGQKEGYIKVVRYAK
                     LGFIICLGFCNLITLNPKITMPLIFILIFSTSFLYKGNLKTRLFTTVLLSIFFILSEI
                     VVTSIFVLFVKEGFEIMLENNSIRVLATILSKIVFLLTCKIICLFKKDVHLDMPIKYW
                     LPLFLIPIFSLFLSVSIFDVSKFFSLESLKFLSLISSVGILYINFIVFYLFKFIIDKT
                     KLSMKYELLEKEIIHKEELRLSNECYKIIVEQTDSVVFEWNIKENKSFVSQAWTEKFG
                     YNNACKNIFKEIKDKDLVHSEDKAIFEGFLESIKKKNMHNQAVYRLKKSNGEYIWCRT
                     SITSIYNDENELLRVVGVIVDVDSDIKKYEELRTRAESDSLTNIYNKGTFEKLVEETI
                     VMNTGDKKDALFIIDLDDFKEINDNFGHPFGDFVLKTFADKIQTSFGSKDLVGRIGGD
                     EFVVYMQDYVTEVNLHKKAKELNRVLSDNYTDLSFSFDASVSIGIARYPQDGTSFFEL
                     FKNADRALYSIKASGKNSYCLFEEELYVQ"
     gene            complement(4753..5583)
                     /locus_tag="KR257_002834"
     CDS             complement(4753..5583)
                     /locus_tag="KR257_002834"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728696.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MerR family transcriptional regulator"
                     /protein_id="HBH0031514.1"
                     /translation="MSQVSKNYFTTGEFAKICGINKKTLFHYDDIGLFSPELKKENGY
                     RYYSYHQLSIFGIISSLREVKMPLKEIKAYIDKRTPNLLIELLEKKTIDIKNEIEKLN
                     NIQALMESTISFTKNACNIDANTITLKEHEEEYLVKTPVTYKEQFLGDEEENFLYECI
                     NFMDNYELSDYGTIGSIIKGEDIINKDFESYSYLFTKVNKEYKKYPVSIKPKGLYVTA
                     YHKGSYETIYKAYEKLLNFFNQNNLRIGDFVYEEYLLYDISVRDSNEYLTQISAEVKM
                     "
     gene            5656..7383
                     /locus_tag="KR257_002835"
     CDS             5656..7383
                     /locus_tag="KR257_002835"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888775.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBH0031515.1"
                     /translation="MKKLIHFLKPYRVLIVVVLIFTFLQTLGTLYIPTLTANIVNNGV
                     VKGDIDYIVKTGLMMMIVAGITALSAVLVCKVSANLSSGFCRDIREAVFIKSQDLSIN
                     DFNNIGTASMITRSTSDITLIGQSVFMFIQLVLPAPIITVSGLFLAYSIDKAMTIIIV
                     VVMFLFMLSAFLVGKKLIKLFKMMQIKMDNMNRVLREVVTGVRVIRAFNRSHFEKKRF
                     DRTAIDYSETAISINKIFAVLMPIVMLIMNLGIVSIIWFGGMRVSNGNMEIGHIMALV
                     EYCILILFYLIMGVMVFMYIPRAGACADRVNQILDIEPEIVDGNGHKDTVSERGHLVF
                     KNVTFSYAQSEEPVLNNITFEAKSGEVTAIIGSTGSGKSTIANIIPRFFEIQSGEISI
                     NGQDIKKIPQKELRDKIGFVPQKAFLFSGTIEENIRYGKEDASIEEVKHAASIAQADE
                     FISDMEDKYDSFVAQGGNNLSGGQKQRISIARALVRKPEVYVFDDSFSALDFKTDKRL
                     RKALKNEIKDSSAIIIAQRISTIMDANQIIVLNDGKIVGIGKHKDLLENCEVYKQIAD
                     SQLSKEELA"
     gene            7420..9282
                     /locus_tag="KR257_002836"
     CDS             7420..9282
                     /locus_tag="KR257_002836"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003432166.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBH0031516.1"
                     /translation="MSEKRIDEQDIEVLSFEDGMSAEKAKDAKKTTKRLLKYMAKQKF
                     KILIIFISVLISSALTVLAPMVMGKAIDQLFNGIKTAVQTGTKFSVNFSTMGGIVSIL
                     LGLYLISAVFIYIQQYIMSGVAQNLVLSMRKDLSDKLNKLPLKYYDSHKKGETLSIVT
                     NDLEKVADSLQEGLMQLITAVVTVVGSIVMMISISVPLTIVSAITLLVSLGITVVIAR
                     KSQERFSENQKALGELNSNIEEIFTGQIVVKAFSKEKDTIRNFKILNQNLYNASRKAQ
                     FSSYAISPIIRFINLIGYVIIAVVGGIFASTGAMTLGSIQAFIQYVNQASEPTTEISY
                     IVNMLQAAIASAERVFTVMDEVEEIKDEESSKVISMPKGKVQFEHVKFGYSDDFILMK
                     DININLNAGDKIAIVGPTGAGKTTLVNLLMRFYEIQGGRITIDGVNIKDLKRGELRTM
                     FGMVLQDTWLFNGSIKENIAYSKSDATMDEIVRAAKSARVDHFIRTLPQGYDTILTED
                     ASNLSQGQKQLLTIARAILSDPSVLILDEATSSVDTRTEVEIQKAMNNLMKGRTSFVI
                     AHRLSTIRDADLILVMKEGTIIEQGSHKELIEKKGFYEELYNSQFTSEYDEDVV"
     gene            9615..10304
                     /locus_tag="KR257_002837"
     CDS             9615..10304
                     /locus_tag="KR257_002837"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888776.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="polyphosphate polymerase domain-containing
                     protein"
                     /protein_id="HBH0031517.1"
                     /translation="MNKKLNYRFEMKHKITEADVLALKSRLYQIMKKDENASKDGKYL
                     IRSLYFDTPEDKALLDKLNGVAIREKFRIRFYNNDCSYIRLEKKIKHYNMTSKLSTNL
                     TKKEVINILNNDIEFLKESTNCLLREFYLKLKCERLEAKSIVDYNREAFIYPVGNVRV
                     TIDSDIKTSVNSVDLFNKDLPTVSVIDENMTVLEVKYDEFIPDFIKDLIQINKTTSTA
                     VSKYASSRLYI"
     gene            10409..11095
                     /locus_tag="KR257_002838"
     CDS             10409..11095
                     /locus_tag="KR257_002838"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003432163.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4956 domain-containing protein"
                     /protein_id="HBH0031518.1"
                     /translation="MILIMTFNDIFKSSFIENVSGFSFVDSALALGSAFLVGLFIYMV
                     YKKTYMGIMYSRPFNVSLVALTMLTTFVILAVTSNVVLSLGMVGALSIVRFRTAIKDP
                     MDLVFLFWSLGSGIVLGAGLIPLAVMGSIIMGLILIFFSNKTISETPYILMVNCNNED
                     SEDIATDKIKKVFTKYQIKSKSVTPEKGIELVFEVRMKDGETSLINDLSQVDGVTNAV
                     LVSYNGDYVA"
     gene            11112..13019
                     /locus_tag="KR257_002839"
     CDS             11112..13019
                     /locus_tag="KR257_002839"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437021.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CotH kinase family protein"
                     /protein_id="HBH0031519.1"
                     /translation="MKDKKFTLLISIMIIFLCAVVGVYSTSSNKSVDLYSDVYIEKYF
                     NRDKVMEVNIEIDESDLKDMNENAIKEEFKVAKVTVDGDTYGNVGIRTKGNSSLISVA
                     NSDSDRYSYKINFDKYNTSQSMEGLTQLNLNNCYSDPSYMREFLTYSICEEMGLATPE
                     FAYAKVSINGEYHGLYLAVEGLKESYLENNFGNVTGDLYKSDEGSSLQYKGDDPESYS
                     NLIVESDKKTADWSKITKLLKSLDTGEDIEKYLDVDSVLKNIAINTALLNLDSYQGSF
                     AHNYYLYEQDGVFSMLPWDFNMSFGGFSGFGGGSQSIAIDEPTTGNLEDRPLISSLLK
                     NETYKTKYHKYLEEIVTKYLDSDYLENMTTKLHDMIASYVKEDPTAFYTYEEFEKNIT
                     SSIEDSSDNKGFGNKGFDNNNSNNSDSNNNSNSENKRSGNQSDEKEVNAELTSSVVKA
                     NTDNETKNKTTNDSESKNNTDKDKSGNDNNQKLEGPMGKGGKSIPGVLEVAEDMSKTI
                     KSQLSGETSSTKQNSGDESSSGIKGSEKFDEDMSGMPEPPEGMDGKMPPGMGNMDKGD
                     MNGKNGNMNMDRNQDNPIEVGGFGNRGGGSVSKTTTYFKLILGGASMIIMSIMLVGVS
                     RVKRRRFIKSK"
     gene            13470..14159
                     /locus_tag="KR257_002840"
     CDS             13470..14159
                     /locus_tag="KR257_002840"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418765.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0031520.1"
                     /translation="MLQKVLWKFLKLVVGLFICSVGIVLTINCNLGLSPWDVFHQGLS
                     NHIGITIGTASIIVGSIVVIADVVLGENVGWGTVFNMLLIGFFMDLLLYSNLIPEADN
                     LFVGIIMLILGLVLLSVGMVFYMGSGLGSGPRDGLMVAIQKKTGKSLKLIRGTIEVGA
                     LIVGFLLGGKVGIGTIISAFGLGYFTQMVFGLFKLDCSKIKHRFIVDDIKFIKVYMSG
                     EKKAAVQNIVK"
     gene            14595..15134
                     /locus_tag="KR257_002841"
     CDS             14595..15134
                     /locus_tag="KR257_002841"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007286148.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HBH0031521.1"
                     /translation="MDIGEKIKRLRTEKQLTQEELANRCELSKGFISQLENNLTSPSI
                     ATLIDILEILGTNLREFFNEIDDERISFTKEDMFETEDEDLKYKLKWLIPNSQKNEME
                     PIIITLYPGGQYKEEKPHEGEEFGYVLAGSIYVHIGEKKNKVKKGESFYFRPKANHYI
                     SNEGKTTAKVIWVSTPPSF"
     gene            15153..16196
                     /locus_tag="KR257_002842"
     CDS             15153..16196
                     /locus_tag="KR257_002842"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011721317.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBH0031522.1"
                     /translation="MVENIIELRDISKHYEELTVLDNFNLDIKKNEFLTLLGPSGCGK
                     TTTLKIIAGFEYADDGKVLFEGKEINNLPPYERQVNTVFQKYALFPHMDVYENVAFGL
                     KIKKTPKDVIDAKVKEVLKLVALEGFERRQVESLSGGQQQRIAIARALVNEPKVLLLD
                     EPLGALDLKLRQEMQIELKRIQKKLGITFVFVTHDQEEALTMSDTIVVMYKGKIQQMG
                     TPQDIYNEPKNSFVAKFIGESNIFDGIMIEDYKVNFCNRDFECVDKGFEKNENIEVVI
                     RPEDIKMVKPEEGMLKGKVTSTVFKGVHYEIELNENGRLWILHNTKNAEVGTELGMDI
                     YPEDIHIMRKENN"
     gene            16198..17034
                     /locus_tag="KR257_002843"
     CDS             16198..17034
                     /locus_tag="KR257_002843"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003432157.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBH0031523.1"
                     /translation="MKRKSFLAYPYVVWSAIFVIIPLILVVFFSFTKESGGGYAFTLE
                     NYKEVIDPIYMKVFGRSILLAGGATLICLIVGYPVAYIISKARVSRRGSLILLFILPM
                     WMNFLLRTYAWVAILGKNGLLNTFLGWFGIQPLAILYTNFAILLGMVYNFLPFMVLPI
                     YTALSKMDNDLINAAHDLGANNMTVFRKIIFPLSLPGVMSGITMVFMPAVTTFAISRL
                     LGGGKIMLVGDLIEQQFTVVGDWNFGSAISIFMMIVILISMSIMSKFGDESDKEGGGL
                     LF"
     gene            17139..17813
                     /locus_tag="KR257_002844"
     CDS             17139..17813
                     /locus_tag="KR257_002844"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437015.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBH0031524.1"
                     /translation="MARWNGFTWKWYGQLLQNESIMSALYYTIVIAILASVISTIVGT
                     ISAIGIHKMRGKSKKLILNVNYLPILNTEIVTAVALMSLFVFVKMEFGFTTMLLAHIM
                     FCLPYVILSVLPKMKQLPDNIEDAAMDLGATPIYALRKVILPQIKPGIVSGFLIAFTM
                     SIDDFIISFFNAGNGVSNLSIEIYGMARRGIKPEINALSTIMFAVVLGLLLLANKKES
                     IVRGIK"
     gene            17813..18865
                     /locus_tag="KR257_002845"
     CDS             17813..18865
                     /locus_tag="KR257_002845"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728693.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="spermidine/putrescine ABC transporter
                     substrate-binding protein"
                     /protein_id="HBH0031525.1"
                     /translation="MIKFKKAISLIAVGMMTVTLFTGCNKATDSTKVLNVYNVGDYID
                     ESLIDKFEKETGIDVQYSTYDTNEMMYQKVKSGSTHYDLVFPSDYMVEKMKNEGLLEK
                     LDFKNIPNMKYLDKSFLNPVYDKTNEYSVAYMWGTLGILYNKKEVKDPMDSWNILWNP
                     KYKGNIMMFDSVRDTIGITLKKLGYSMNSVNPKEINEAKNLLMKQKDLVLAYVNDEGK
                     DRLLGGEVAMGMLYSGDAVTLMEQNPDLDYAIPKEGTNKWVDAMCVPTTAQNKKEAEL
                     FINFLLDPENAKVNAEYIGYSTPNTGALKLLDPEITQNPVAYPSKEVLDKCETFEDIG
                     ENIKLYDKAWIELKSK"
     gene            19095..19943
                     /locus_tag="KR257_002846"
     CDS             19095..19943
                     /locus_tag="KR257_002846"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902229.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GGDEF domain-containing protein"
                     /protein_id="HBH0031526.1"
                     /translation="MNRINKKIDLLILALLVFIFLIVGIVILSIRTENKLNVFIMLAI
                     IFFIIMLTYLSNSVVGLITSSIIIFMYTSYILYNNITHNMDVEFISYMWIIATPVSSI
                     IMGNLNKSINELQNTNKKLSEQYKELVTIDSETGLRNLKIFYNDVNMEISKSIRHNTD
                     FSLMIVKLPYYGNLQTIFGENKTNKIVKYIGSNIIECTRNEDIIYSLQKDMIGILMPN
                     TSLEGSKVVKDRIKKRIKELNLDLNNRGKYVNIDVKIAFLQYKSSFGDSINFKNIVEE
                     ELQYDV"
     gene            19933..>21591
                     /locus_tag="KR257_002847"
     CDS             19933..>21591
                     /locus_tag="KR257_002847"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437010.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="polysaccharide deacetylase family protein"
                     /protein_id="HBH0031527.1"
                     /translation="MMFKIFNKSLLKLVVVLSIVLTISNFSLSSYASEITSSTDKVLI
                     IYDSKKETAYNRDILNIMRTLLGRFSSDIELLKLSNYDGEINKNYYSHIFILGINENS
                     YNNDKNTKNLISSLNSYKGTICWLGYGIENLLEHKKYNLDYVGKTNNIVSVNYRGKSY
                     NLDEHYVFNIVESKDTSNKVIGSINDTLNKYPYIINDKNLFYVSKLDLDGVLFYIFCD
                     SLNDIFNIKTFDKGRIFVRIEDVHAFREPKNLVEIADYLSSKNIPFTIALIPAYVNPK
                     NHKVITLSESPEIVKAIKYMQDKGGTVILHGYTHQYKKEEVSGEGYEFWDGKKDEPLK
                     ENMKIFVKDRVLNGLRVCIENGIYPLAFEAPHYAMESEGYKELKKYFSTYMGQHQNND
                     KKFSTNTYPYIIRDTEEFNIFIPENLGYIDPEDKFTFQNIKENLNKLSIVRGFSGGFF
                     FHSYLNIEYLKNTIEYLEKQNIEFMNLRDFNNWVKVDEIQIRNNGDEIIVNYDKDLDE
                     ITKSDTRFKSISNISKVLIFIVSISVLIFVIIFIYFKRIDKKKFL"
BASE COUNT         8477 a         2171 c         3728 g         7215 t
ORIGIN      
        1 ttgaatattc aataaaaagt tcgaaaaata tcaattctga tataaactga ataaatacag
       61 ttgaatatta aattattatt ttatcaaaaa tatgcaaagt actacacctt caaatatcac
      121 ctaaagtaat taaaaggcaa ttaaagtgaa gtagttcaag tatttctaaa ataagtttaa
      181 taaattctat aataatttat tttttgcctt aaaattgcct taaaatccaa acaattttaa
      241 aactaatgta ctataaaaag ctggtataat ttaaatatag taaaaaataa gatttatctt
      301 atctattggg atttaattat ttaatcaata tatttatacc atttaattta aataaaaagt
      361 ctattaagga gtgagcttat gagtaagtta atttatatag cagatgatga agataatata
      421 agaaatttgg taaagacatt cttaaaaaat gaaggtcatg atgttatgga ttttaaaacg
      481 ggtgatgaac ttttagaaca atttaatata aaggagtgtg acttagtaat actagatata
      541 atgatgcctg gctcaagtgg ttttgaagta tgtacaaaac ttcgtgagaa aagtacagtc
      601 ccaataatca tgcttactgc aagagataca gatatagatt atattacagg gataacctta
      661 ggtagtgatg attattttac aaaaccattt agcccaatgt ctttggttat gagagtaaaa
      721 tctatattta gaaggataga gtttgaaaag aaacaaaatt atgataaata tagtaactcg
      781 atagatatgg aattaaaatt tggtgatgta ataataaata aaaagaataa aatcgttaca
      841 agtaaaaatg taaatataga ccttacacca aatgaatata acctattgac ttatttgttt
      901 gaaaatatag atagagcaat ttccagagat gaattattaa acaaaatatg gggatacgat
      961 atagaagttg agacaagggc tgctgatgat acagtgaaga gattacgtaa aaaaatttta
     1021 gatacaaata ttttaataga aactgtatgg gggtttggat ttaggttgaa ggagaaaagt
     1081 taagatgaag aatggaaatg acaagaatag aattggaaag attaaatcca aatttaaatt
     1141 aaagttctca aagaaaaata taagcataaa aactaggatt ttgttgagta tactttgttt
     1201 gataattata gtatttatga taatattagt atcttttaat gtatttcttg atacatatat
     1261 aaaaacaact gcgaatgaag aattgacaaa gtctacagaa atagtagaac atatggatag
     1321 taattttaga cctattaagc caccacaaga tgatggaaag cttcctccca aagtattatc
     1381 taattttatg agaaatgtac aagataaagt taggatggca gaaacacaat cagatgctga
     1441 tgctatggta gttgattcta agtataacct gatatttcca acaagagagg acgatttctt
     1501 aaaaaatgtt gatgagatgg agctgattag ggagtgtatt caaaatgaaa aattagattt
     1561 aaattcagat gcaaatacac ggatatctac cagaaataag gattattata tttcaactgt
     1621 aaaaattacc agtatatatg gtgaacaaga caagtatctt atacttttta tagacatatc
     1681 aaaaactcta aatctagcac aaaagataaa tattgtatta atatctgtaa tgtgttttgc
     1741 tggaatatta gcaatattta cagctgtgat tttatctgag aaaattgcta aaccgataaa
     1801 agagttgtgt gagtttgcaa aaaaaatggg tcaaggagat ttcaaaagaa cctactttga
     1861 cttttcagat aaagaattag tagagctctc aactgttatg aataagagtg ctgagtatct
     1921 ggataagtat gataatgaac aaaaaatatt ttttcaaaat gcatctcatg aattaaggac
     1981 accacttatg tctattaaag gttatgcaga agctataaaa tataatgtta tagatagtaa
     2041 acatgcaagt gatataattc ttgaagaaag tgataggtta agtgatatgg ttgaagattt
     2101 attatacatt tctaaaatag ataatataac taaagatttt gaacttgtag aatgtgattt
     2161 aagagaagta ctttcaaact gtggagctag gcaaaatgta agagctataa ataaggggat
     2221 aaagtttatt tatgaatttg atgaagaaat ggttttattt gaatgtgatg aaaaaaacat
     2281 ttccaaagca tttatgaatc ttatagaaaa tgctttgaga tacgctaaga gtgaaataaa
     2341 aatagtgtgt aagtataatc aaaaaaatat agttgtgata atagaagatg atggaattgg
     2401 aatcaagaaa gaagatttac ctcatgtttt tgaaagattc tataagggag taggaggaaa
     2461 tcatggaatt ggattatcaa tagttaaatc tattgtaaat aagcatggtg ggcgtatata
     2521 cgtagaaaat ggcaaaaaag gagctaaatt tactatatta tttaaattgt aaaaaaatta
     2581 gagaaaatat agagatgttt gaagttgttt tttatatata tctgttgtat actgttgaaa
     2641 aaagaacaat attaagctga catatattac gatagttgac atttaaagta aatgcttaaa
     2701 tatagatacg aaaggaaaag taaaatctga agtgtattta ggtttaagta agcttcttat
     2761 tttataaaaa atatgtatga aagaacagct gatttttaat attacaaatt tagtaacggt
     2821 tgtatttgaa gcttttgtca tccatatgtt tttatcagac tttttaggcc agaaagaagg
     2881 gtatataaaa gttgtaagat atgctaaact gggttttata atatgtttag gattctgtaa
     2941 tttaataact ttaaacccta aaatcacaat gcctttaatt ttcatcctta ttttttcaac
     3001 atcattttta tataaaggaa atttaaagac acgattgttt actactgttt tattaagtat
     3061 attctttata ctgtcagaaa ttgtagttac aagtattttt gttttatttg taaaagaagg
     3121 ctttgaaata atgcttgaaa ataatagtat aagagtattg gcgacaattt tatctaaaat
     3181 tgtctttttg ttgacttgta aaattatttg tctatttaaa aaagatgtac atttagatat
     3241 gcccataaag tattggctcc ctttattttt aatacctata tttagtttat ttctgtctgt
     3301 ttctatcttt gatgtaagta aattttttag tcttgaaagt ttaaaatttc taagcttaat
     3361 atctagtgtt ggtattttat atattaattt tattgtcttt tatttattta aatttattat
     3421 agataaaact aaactatcta tgaaatatga actacttgaa aaagaaataa ttcataagga
     3481 agaattaaga cttagtaatg agtgttataa aattattgtt gaacagactg attctgtcgt
     3541 tttcgaatgg aatatcaaag aaaataaatc atttgtatcg caggcttgga ctgaaaaatt
     3601 tggatataac aatgcatgta agaatatttt taaagaaatt aaagataaag acttagttca
     3661 ttctgaagat aaagctatat ttgaaggttt tcttgaaagt attaaaaaaa agaatatgca
     3721 caatcaagca gtatatcgtt taaaaaaatc taatggtgaa tatatttggt gtagaacatc
     3781 aattacaagc atttataatg atgaaaatga acttttaaga gttgtcggag taattgtaga
     3841 tgtagatagt gatataaaaa aatatgaaga gttaagaact agagcagaaa gtgactcatt
     3901 gaccaatata tacaataaag gtacatttga aaaattagtg gaagaaacta tagttatgaa
     3961 tacaggtgat aaaaaagatg cattattcat tattgatttg gatgatttta aagaaataaa
     4021 tgataatttt ggtcatccat ttggtgattt tgtactaaaa acatttgctg ataagataca
     4081 aactagtttt ggtagtaaag acttagtcgg aagaattggt ggagatgaat ttgttgtata
     4141 tatgcaagat tatgttacag aagtaaattt gcataaaaaa gctaaagaat taaatagagt
     4201 actttcggat aattacactg atttgagttt tagttttgat gcttctgtca gtataggtat
     4261 tgcaaggtat cctcaagatg gaacttcatt ttttgaattg tttaaaaatg cagatagagc
     4321 actttatagc ataaaagcat caggtaaaaa ttcatattgt ttatttgaag aagaactata
     4381 tgtacagtga atttgaattt agattttatg tgagagtaag atttatatat acttgtggct
     4441 gtctgattta taaaatatgt tactttgtat atttttatat gtttcagtaa ggttaattaa
     4501 cataagcaaa ggtgtaagta aatttatatt agtttaagtt tacttacacc tttataaaaa
     4561 tacaaataat agattcattt acattcttaa atgattaaag ctctttacct tctaaacatg
     4621 cataacatat cgttataatt ccagtaaata agactaaaat acccattcct aagattacag
     4681 tttcattatc tattactcca aatgttttta aagtaactta tttcgctttg tatcataata
     4741 atttgtctct ttttacattt taacttctgc tgagatttga gttagatatt cgttagaatc
     4801 tcgcacactt atatcatata gaagatattc ttcataaaca aaatccccaa tacgtaaatt
     4861 attctgatta aaaaaattta ataacttttc ataagccttg taaatagttt cataactccc
     4921 tttatgataa gcagttacat aaagtccctt tggtttgatt gatacaggat atttcttgta
     4981 ctctttatta acttttgtaa ataaatatga atatgattca aagtctttat taattatatc
     5041 ttcaccttta atgattgagc caatcgtacc ataatcactc aattcatagt tgtccataaa
     5101 gttaatacat tcatataaaa aattttcttc ctcatctcct aaaaactgtt ctttatatgt
     5161 aacaggtgtt ttgaccaagt actcttcttc atgttctttt aaagtaatag tattcgcatc
     5221 tatattacag gcatttttag tgaatgaaat agtagattcc attagagctt gaatattatt
     5281 tagtttttca atttcatttt taatatcaat ggttttcttt tctaaaagct caattagtaa
     5341 attaggtgtt cttttgtcta tataagcttt aatttctttt aaaggcattt ttacttccct
     5401 aagtgaagaa attataccaa aaatgctaag ttgatggtat gagtagtatc tatatccatt
     5461 ttctttcttt aattctggtg agaaaagacc tatatcatca taatggaaaa gtgttttttt
     5521 attgattcca caaatctttg caaattctcc agttgtaaaa taattttttg aaacttgact
     5581 cataattata attcctcctt gactatcctg ttacagtata gtttatcata gtattttgta
     5641 aaggagtgtg attatatgaa aaaattaatt cattttttaa aaccatatag agttttaatt
     5701 gttgtagttt tgatatttac gtttttacaa acacttggaa ctttgtatat accaacactt
     5761 acagcaaata tagtaaacaa tggtgtagta aagggagata tagattatat tgtaaaaaca
     5821 ggtttaatga tgatgatagt agctggtata acagctttat cagctgtgtt agtttgtaaa
     5881 gtatcagcaa atctttcatc tggattttgt agagatatta gagaagcagt atttataaaa
     5941 tcacaagatt tatcaataaa tgattttaat aatataggta cagcatcaat gattactagg
     6001 agtactagtg atattacttt aataggtcag tctgtgttta tgtttattca attagtatta
     6061 ccagcaccaa ttataactgt ttctggtcta ttcttagcat attctataga taaagcaatg
     6121 acaattatta ttgttgtagt aatgttttta ttcatgcttt cagcattttt agttggtaaa
     6181 aagcttataa agttgtttaa aatgatgcaa ataaaaatgg acaatatgaa tagggtgtta
     6241 cgtgaggtag taactggagt aagagttata agagctttta ataggagtca ttttgaaaaa
     6301 aagagatttg atagaactgc aatagattat tctgaaacag caatttcaat aaataaaata
     6361 tttgcagtac ttatgcctat tgtaatgtta ataatgaatt taggtatagt aagtattatt
     6421 tggtttggtg ggatgagagt cagtaatgga aatatggaaa taggtcatat aatggcactt
     6481 gttgaatatt gtatcttaat tttattctat ttaatcatgg gagtaatggt atttatgtac
     6541 atacctagag caggtgcatg tgcagataga gtaaatcaga tattagatat agaacctgaa
     6601 attgtagatg gaaatggtca taaagatact gtctcagaga gaggacattt agtatttaaa
     6661 aatgtaacct tttcatatgc acaatcagaa gaacctgtgt taaataatat aacatttgaa
     6721 gcaaaatctg gagaagtaac tgcaattata ggaagcactg gctcaggcaa atctactatt
     6781 gcaaatataa taccacgttt ttttgaaatt caatctggag aaatatctat aaatggtcag
     6841 gatattaaga agattcctca aaaagaactt agagataaga ttggatttgt accacaaaaa
     6901 gcttttttat ttagtggaac aatagaagaa aatataaggt atggaaaaga agatgcaagt
     6961 attgaagaag taaagcatgc tgcaagtata gctcaagctg atgaatttat ttctgatatg
     7021 gaagacaagt atgactcatt tgtagcacaa ggtggaaata atttgtcagg tggtcaaaaa
     7081 cagagaatat ccattgcaag agcgttagtt agaaagcctg aagtatatgt ctttgatgat
     7141 agtttttctg cattagattt taaaacagat aaaagactta gaaaagcgtt gaaaaatgaa
     7201 atcaaagatt catcagctat aattatagca caacgtataa gtacaatcat ggatgctaat
     7261 cagattatag ttttaaatga tggaaaaatt gtaggtattg gaaaacataa agatttactt
     7321 gaaaattgtg aagtttataa gcaaattgcg gattcacaac ttagtaaaga agaacttgca
     7381 taaaatgaag aattaatctg atatttggag gtgtatgata tgagtgaaaa aagaatagat
     7441 gaacaagata tagaagtact tagttttgaa gatggcatgt cagcagaaaa agctaaggat
     7501 gcaaaaaaaa ctactaagag attattaaaa tatatggcaa aacaaaagtt taaaatatta
     7561 attattttta tttcagtatt gataagttca gcgcttacag ttttagcacc tatggttatg
     7621 ggaaaagcta ttgaccaact atttaatgga ataaaaactg cagtccaaac aggtacaaaa
     7681 ttcagtgtga attttagtac tatggggggg atagtatcaa tacttctagg gttgtactta
     7741 attagtgcag tatttatata tattcaacag tatattatgt caggagttgc acaaaatcta
     7801 gttcttagca tgagaaaaga tttaagtgat aaactcaata aacttcctct taagtactat
     7861 gattctcata aaaaggggga aacacttagt atagtaacaa atgatttaga aaaagtagca
     7921 gatagtttac aagaaggatt aatgcaactt attacagcag tagttacagt agttggttct
     7981 attgtaatga tgataagtat aagtgtacca cttacaatag tatcagctat aacattactt
     8041 gtttcattgg gtattactgt tgtaattgca agaaaatcac aagaaagatt ctctgaaaat
     8101 caaaaggcac taggagagtt aaatagcaat atagaagaga tatttactgg tcaaatagtg
     8161 gttaaagcat ttagtaaaga aaaggatact ataagaaact ttaaaatatt aaatcaaaat
     8221 ctttataatg caagtagaaa agcacagttt tcgtcatatg caatatctcc aattattaga
     8281 tttataaacc taattggcta tgttattata gcagttgtag gtgggatatt tgcatcaact
     8341 ggagcaatga ctcttggtag tatacaagcg tttattcaat atgtaaatca agcatcagag
     8401 cctactacag aaatatctta tattgtaaat atgcttcaag cagcaatagc atctgcagag
     8461 agagttttta cagttatgga cgaggtggaa gagataaagg atgaagaatc ttcaaaggtt
     8521 attagcatgc ctaaaggtaa agtacaattt gagcatgtta aatttggata tagtgatgat
     8581 tttattctta tgaaagatat taatatcaat ctaaatgcag gagataagat tgcaattgtt
     8641 ggacctacag gagctggaaa gacaactctt gtaaatttac ttatgagatt ttatgagata
     8701 caaggtggaa gaattactat tgatggtgtt aatataaaag atttaaagcg tggagaactt
     8761 agaactatgt ttggtatggt tcttcaagat acatggctgt ttaatggaag tataaaagaa
     8821 aatattgcat atagtaagtc agatgccaca atggatgaaa ttgtaagagc agcaaaatca
     8881 gcaagagtag accattttat aaggacttta ccacaagggt atgacactat attgactgag
     8941 gatgcttcta atctatctca aggtcaaaag caacttctaa caattgccag ggcaatactt
     9001 tcagacccat cagtattgat tcttgatgaa gcaacatcta gtgtagatac tagaacagag
     9061 gtagaaattc aaaaggcaat gaataacttg atgaagggaa gaactagttt tgttattgca
     9121 catagattat caactattcg agatgctgat ttaatattag taatgaaaga aggaactatt
     9181 attgaacaag gaagccataa ggaacttatt gaaaagaaag gattctatga agaactttat
     9241 aacagtcaat ttacaagtga atatgatgaa gatgttgtat gattatcaag ttttaggcaa
     9301 ctaaatgatt gataaatatt aagttaaata tagtaacatg taaggttata tggaataaga
     9361 gtatttctct atttcatata acctttttta tttatcaaaa taagataaaa tttcctttct
     9421 aaattagatt gaagaatgta tttatcaata taaaagtaaa ataatcatta ttattagtga
     9481 agtaaatatt gtttgccaca tatatgccat aaagatgcac ttattttacg gagatttaac
     9541 aaagtagtgt aaagtatact ctaaatataa aataaatcaa atagagttaa ataaattgag
     9601 aggtgatata aatagtgaat aaaaaattga actatagatt tgaaatgaag cacaaaataa
     9661 ctgaagcaga tgtgttagct ttaaaatcaa gactctatca aataatgaag aaagatgaaa
     9721 atgcatctaa agatggaaaa tatcttatta ggagtttata ttttgatact cctgaagata
     9781 aagcactttt ggataaatta aatggcgttg caataagaga aaagtttagg ataagatttt
     9841 ataataatga ctgctcttat ataaggctag agaaaaaaat caaacattac aacatgacat
     9901 caaagctatc aactaattta accaaaaaag aagtaataaa tatactaaat aatgatattg
     9961 aatttctaaa agagtcgaca aattgtttat taagagaatt ttatttgaaa ttaaaatgtg
    10021 aaagattaga ggcaaaaagc atagttgatt acaatagaga agcttttatt tatccagttg
    10081 gaaatgtaag agttacaatc gatagtgata ttaaaacttc tgtaaattcg gtagatttat
    10141 ttaataaaga tttgccaact gtttcggtaa ttgatgagaa tatgactgta ttggaggtta
    10201 aatatgatga atttatacca gattttataa aggatttaat tcaaattaat aagactacct
    10261 ctacagcagt ttcaaagtat gcttcaagta gattatatat ttaagaataa aggctatgat
    10321 ttatataaag atatacataa ataaggttaa aaaacaaata agttaaaaat aaataaaata
    10381 aaaaataaat aagttaaaaa taggaaggat gattttaatt atgacattta atgatatttt
    10441 taaatcaagt tttatagaaa acgtatcagg tttttcattt gtggacagtg ctttagcact
    10501 aggttcagct tttttagtag gtttgtttat atatatggtc tataaaaaga cttatatggg
    10561 aattatgtat tctcgaccat tcaatgtgtc gcttgtagca cttacaatgc ttacaacttt
    10621 tgtaatattg gcagttactt caaatgtagt tttatcctta ggtatggttg gtgctttatc
    10681 tatagtaaga tttagaacag caattaaaga cccaatggat ttagtatttc tattttggtc
    10741 attgggttca ggtatagttt taggagcagg tttgattccc ttagctgtca tgggttcaat
    10801 aattatggga ttgattctaa tattcttttc aaataaaaca atatctgaaa ctccatatat
    10861 attgatggta aattgtaata atgaagattc agaagatata gcaactgata aaattaaaaa
    10921 agtatttact aaatatcaaa taaaatcaaa aagtgttaca ccagaaaaag gaatagaatt
    10981 agtgtttgaa gtaagaatga aagatggaga aacaagtctt ataaatgact tgagtcaagt
    11041 agatggagtt actaatgcag ttcttgtaag ttataatggt gactatgtag catagagagg
    11101 agtaatcttt tatgaaagat aaaaaattta cccttcttat ctcgattatg attatatttt
    11161 tatgtgctgt agttggagtt tatagtacat ctagcaacaa aagtgttgat ttatatagtg
    11221 atgtatatat tgaaaaatat tttaacagag acaaggttat ggaagttaat atagagatag
    11281 atgaaagtga cttgaaggat atgaatgaaa atgctataaa agaagaattt aaggttgcaa
    11341 aagtaactgt agatggagat acatatggaa acgtaggtat aagaactaaa ggaaattcaa
    11401 gtcttatatc tgtagcaaat agtgatagtg atagatacag ctataagatt aattttgata
    11461 agtataatac tagtcaaagt atggaagggc ttactcaatt aaatcttaat aactgttact
    11521 ctgacccatc ttatatgaga gagtttttaa catatagtat ttgcgaggaa atgggattag
    11581 cgactccaga atttgcatat gctaaagtct ctataaatgg cgaatatcat ggtttgtatt
    11641 tggcagtaga aggattaaaa gagtcttatc ttgaaaataa ttttggtaat gtaactggag
    11701 acttatataa gtcagatgaa ggaagctcgt tgcaatataa aggagatgac ccagaaagtt
    11761 actcaaactt aatcgttgaa agtgataaaa agacagctga ttggtctaaa atcacaaaac
    11821 tattaaaatc tttggataca ggtgaagata ttgaaaaata tcttgatgta gattctgtcc
    11881 ttaaaaatat agcaataaat acagctttat taaaccttga tagctatcaa gggagttttg
    11941 cccataacta ttatttatat gagcaagatg gagtattttc tatgttacca tgggatttta
    12001 atatgtcatt tggtggattt agtggttttg gtggaggtag tcaatctata gcaattgatg
    12061 aacctacgac aggtaattta gaagacagac ctctcatatc ctcgttatta aaaaatgaga
    12121 catacaaaac aaaataccat aaatatctgg aagagatagt aacaaaatac ctagattcag
    12181 actatttaga gaatatgaca acaaaattgc atgacatgat agcatcatat gtaaaagaag
    12241 acccaacagc attttatact tatgaagaat ttgaaaaaaa tataacatct tcaattgaag
    12301 attctagtga taataaggga tttggtaata aagggtttga caacaataac tctaataaca
    12361 gtgattctaa taataattct aatagtgaaa ataagcgctc tggaaatcaa agtgatgaaa
    12421 aagaagttaa tgctgaatta acatcaagcg tagtcaaagc taatacagat aatgaaacta
    12481 aaaataaaac tacaaatgat agtgaaagta agaataatac agataaagat aaaagtggaa
    12541 atgataataa tcaaaagcta gaaggtccta tgggtaaagg aggtaagtca ataccagggg
    12601 ttttggaagt tgcagaagat atgagtaaaa ctataaaatc tcaattaagt ggagaaactt
    12661 cttcgacaaa gcaaaactct ggtgatgaaa gttcaagtgg aattaaaggt agtgaaaagt
    12721 ttgatgagga tatgagtggt atgccagaac cacctgaggg aatggatggt aaaatgccac
    12781 caggaatggg taatatggat aagggagata tgaatggtaa aaatggcaat atgaatatgg
    12841 atagaaatca agataatcca atagaagttg gaggttttgg taatagagga ggaggctctg
    12901 tgagtaaaac aacaacatac ttcaaattaa ttttaggtgg agcttcaatg ataataatgt
    12961 cgattatgtt agtaggtgta tcaagggtaa agagaagaag atttataaag tcaaaataag
    13021 attaaaattg aatataaata attttaatac tgttaagtct aaatatttac ttagcagtat
    13081 tttttagaaa ataatgtgtt tgattaataa tataaggtaa taaattgata aaaattaaat
    13141 acagcatatt aataatacat aataaagtaa taaaaaactg tttaagtata ataacttata
    13201 tttagacagt ttttttcatt tataaataat ataaatgaaa ttgaaaacat ttgaaggata
    13261 gaaattggtt ggataaatgt ataaattact tcaccaaaaa ataatgacaa aaactgtaac
    13321 taagttgtaa taaaatggta gttatttagc ataaaataat gtatcataga agtatattat
    13381 aaaattaata aaataagatt tttgtaagaa aactgctggc ttttgatatt tagagtgagt
    13441 agttaaatta tgtttaggag gagtagaatt tgttgcaaaa agtattatgg aaatttttaa
    13501 agctagtagt cggtttattt atatgttcag ttggtatagt attgacgata aattgtaacc
    13561 ttggattatc tccctgggat gtatttcatc aaggactttc aaatcatata ggaataacta
    13621 taggaactgc ttctataatt gtaggctcta tagtagttat tgctgatgtc gttcttggag
    13681 aaaatgtagg atggggaact gtttttaaca tgctactaat tggatttttt atggatttac
    13741 ttttatatag taatttaatt ccagaggctg ataatttatt tgtaggaata attatgttga
    13801 tattaggatt ggttcttttg tctgttggaa tggtatttta tatgggaagt ggtttaggaa
    13861 gtggacctag agatggtttg atggttgcaa ttcaaaagaa aacaggaaaa tcacttaaat
    13921 taataagagg tactatagaa gttggagcat taatagtagg atttttatta ggtggaaaag
    13981 ttggtatagg aactataata agtgcatttg gattggggta tttcacacaa atggtatttg
    14041 gcttatttaa attagattgt agtaagatta aacatagatt tatagtagat gatataaaat
    14101 ttatcaaagt gtatatgagt ggtgagaaaa aagctgctgt tcaaaatata gttaagtaat
    14161 ttaagaataa attcaacgaa atgttaagta ttttaaatta acattttgtt tagatagata
    14221 aattgaatat taaaagaata ttaaaatatg aggattgcta gaacactata aaatatagat
    14281 ttctagcaat tttttatttg ttcaatattt ttttagtact agaagtctta ttctctattt
    14341 aatgaatgaa ttaatttata attagagata ctaaacttta tagatattaa tataaacacc
    14401 tttaaactgt gtattttcca aagcctttaa aatgcttgta tttattctaa ataaaaaaat
    14461 aaaaaaatgt caaaaaaact cttgtattat atccaaattt tatatataat tacctatgtt
    14521 gtttagaaat tttaaactca atgtttagta aacaaaatgt ttagtaaaat aaaacagaaa
    14581 ctaggaggtg caacatggat ataggtgaaa agataaaaag attaagaaca gaaaaacaac
    14641 tgacccagga agagttagct aatagatgtg aattgtcaaa gggatttatt tctcaattag
    14701 aaaataactt aacatcacca tccatagcta cccttataga tatacttgaa atactaggta
    14761 caaatttaag ggaatttttt aatgaaatag atgatgaaag aatcagtttt acaaaagaag
    14821 atatgtttga aactgaagat gaagatttaa aatataaatt aaagtggtta attccaaatt
    14881 cacaaaaaaa tgaaatggag ccaataataa taacattgta tccaggagga cagtataaag
    14941 aagaaaagcc acatgaaggt gaagaatttg gatatgtatt agcaggttca atatatgtcc
    15001 atataggcga aaagaaaaat aaagtaaaaa aaggagagag tttttacttt agaccgaaag
    15061 caaatcacta tatatcaaac gagggcaaaa ctacagcaaa agtgatttgg gtaagtacgc
    15121 caccatcatt ttagaataga ggtgtttaat aattggtaga aaatataata gaattaaggg
    15181 atatatctaa acattatgaa gaacttactg ttttagataa tttcaattta gatataaaga
    15241 aaaatgagtt tctaacattg cttggaccaa gtggatgtgg aaaaactaca acattaaaaa
    15301 taatagcagg atttgagtat gctgatgatg gtaaagtttt atttgaaggt aaggagataa
    15361 ataatttgcc accatatgaa agacaagtaa acacagtatt tcaaaaatat gctttatttc
    15421 cacacatgga tgtttatgaa aatgtagctt ttggattaaa aattaaaaag actccaaaag
    15481 atgtaataga tgctaaagta aaagaggttt tgaaacttgt tgcactagaa ggttttgaaa
    15541 gacgacaagt tgaatcattg agtggaggac aacaacaaag aattgcaata gcaagagctc
    15601 tagtcaatga accaaaggta ttattactag atgaaccact tggagcactt gatttaaagt
    15661 taagacaaga gatgcaaata gaattaaaga gaatccaaaa aaaattagga ataacatttg
    15721 tttttgtaac tcatgaccaa gaagaggctc ttactatgtc agatactatt gttgtaatgt
    15781 ataagggcaa aattcaacaa atgggaacac cacaagatat atacaatgaa cctaaaaatt
    15841 catttgtagc taagtttata ggtgaaagta acatatttga tggaattatg atagaagatt
    15901 ataaagttaa tttctgtaat agagattttg agtgtgttga taaaggattc gaaaaaaacg
    15961 aaaatataga agtagtaata agaccagaag atataaaaat ggtaaagcca gaagaaggaa
    16021 tgttaaaggg gaaagttaca tctacagtgt ttaaaggagt gcattacgag atagaattga
    16081 atgaaaatgg aagattgtgg atacttcata atactaaaaa tgctgaggtt gggactgaac
    16141 taggcatgga tatatatcca gaagatatcc atataatgag aaaagagaat aactaagatg
    16201 aaaagaaaat cttttttagc atatccatat gtagtttgga gtgcgatatt tgtaataatt
    16261 cctttaatat tagtagtatt ttttagtttt acaaaagaat caggtggagg ttatgccttt
    16321 acacttgaga attataaaga agtaattgac cctatatata tgaaagtttt tgggcgttct
    16381 attcttttag caggaggagc tacattaata tgccttatag ttggttatcc agtggcatat
    16441 ataatttcaa aggctcgtgt aagtagaaga ggttcattaa tattattgtt tattcttcct
    16501 atgtggatga actttctttt aagaacatat gcatgggttg ctatattagg aaaaaatgga
    16561 cttttaaata catttttagg ttggtttgga atacaaccat tagcaatttt gtatactaat
    16621 tttgctatac ttttaggtat ggtgtataac tttttaccat ttatggttct tccaatatat
    16681 acagcactat caaagatgga taatgatttg ataaacgctg ctcatgactt gggtgcaaat
    16741 aatatgacag tttttagaaa aattatattt cctttgagtt tgccaggtgt aatgtctgga
    16801 ataactatgg tatttatgcc agcagtcact acttttgcaa tatcaagact gttaggtgga
    16861 ggtaaaataa tgctggttgg agatttgatt gaacaacagt ttacagttgt tggagattgg
    16921 aactttggtt cagctatatc gatatttatg atgatagtaa tattaatatc tatgtctata
    16981 atgtcaaaat ttggagatga atctgacaaa gaaggcggtg ggttactatt ttaaaattaa
    17041 agaaaataac ttctaatata tatttagcat tagtattctt atttttgtat gcacccatat
    17101 ttgctttggt actattttct ttcaatgatt caaaatcaat ggcaagatgg aatggattta
    17161 catggaagtg gtatggtcaa ttacttcaaa atgagagtat aatgagtgct ttatattata
    17221 ctattgtaat agctatatta gcgtctgtaa tatctacaat agtaggaact ataagtgcta
    17281 taggaataca taagatgaga ggtaagagta agaaattaat actaaatgta aactatcttc
    17341 ctattttaaa tacagagata gttacagcag tagctcttat gagtctgttt gtatttgtaa
    17401 aaatggaatt tggatttaca acaatgctat tggcacatat aatgttttgt ttgccatacg
    17461 ttatactttc agttttgcca aaaatgaagc aattacctga taatatagaa gatgcagcta
    17521 tggacttggg agcaacacct atatacgctc ttagaaaagt aattttacca caaataaaac
    17581 caggtatagt ttctggattt ttaattgcat ttactatgtc aatagatgac tttataataa
    17641 gtttctttaa tgctggaaat ggtgtaagca atctttctat agaaatctat ggaatggcta
    17701 gaagaggtat aaaacctgaa ataaatgcat tatcaacaat aatgtttgca gtggttctag
    17761 gtttactttt actagctaat aaaaaagaat ctatagtaag ggggattaaa taatgattaa
    17821 gtttaaaaaa gcaatatccc ttatagctgt aggtatgatg acagttactt tatttacagg
    17881 atgtaataaa gcaactgatt ctacaaaagt tttaaatgta tataatgttg gagattatat
    17941 agatgagtct cttatagata agtttgaaaa agaaacagga atagatgttc aatattcaac
    18001 ttatgatact aatgaaatga tgtatcaaaa agtaaagagt ggtagtacac actatgattt
    18061 agtatttcct tcagactata tggtagagaa aatgaaaaat gaaggtcttt tggaaaaatt
    18121 agattttaag aatataccta atatgaaata tttagataag agttttttaa atcctgtata
    18181 cgacaaaact aatgaatata gtgttgcata tatgtgggga actcttggaa tattgtacaa
    18241 taagaaagaa gttaaagacc ctatggatag ctggaatata ctttggaatc caaagtataa
    18301 gggaaatata atgatgtttg actctgttag agatactata gggataactc ttaaaaaatt
    18361 aggatatagc atgaatagtg taaatccaaa agaaataaat gaagctaaaa atcttttaat
    18421 gaaacaaaag gatttagtat tggcttatgt aaatgatgaa ggtaaggata gattgcttgg
    18481 tggagaagtg gcaatgggta tgctgtattc tggagatgca gttacactaa tggagcaaaa
    18541 tcctgacctt gattatgcta tacctaaaga gggaactaat aaatgggtag atgctatgtg
    18601 tgtacctaca acagcacaaa ataagaaaga agctgagctg tttataaact ttttattaga
    18661 cccagagaat gcaaaagtaa atgctgagta cattgggtat tcaacaccta atacaggagc
    18721 actaaaatta ttagacccag aaataactca gaatcctgtt gcatatccat ctaaagaagt
    18781 acttgataaa tgtgaaactt ttgaagatat tggtgaaaat ataaaattat atgacaaggc
    18841 ttggatagag ttaaaatcaa aatagggtct tgttgtttta agtaaattta cttaataaat
    18901 acttaataaa actgttcttt tttagaaaat ttattttcta attattgaac agttttattt
    18961 tttgtttaag ttatattcat atgcaattta aatagtttat taataaatga aaacttattt
    19021 gtataatgac tttaataata attagaaaaa atgggcaact taatagaata attggaggtg
    19081 taaatttata aaaaatgaat aggataaata aaaaaataga tttattaata ttggctttgc
    19141 tcgtttttat atttttaatt gttggaatag taatactatc gattaggaca gaaaataaat
    19201 tgaatgtgtt cataatgtta gcaataattt tttttataat aatgttaact tatttatcaa
    19261 attcagtagt ggggttgata acaagttcaa taattatatt tatgtataca tcctatattt
    19321 tatataacaa tattactcac aatatggatg ttgaatttat atcatatatg tggataatag
    19381 caacaccagt atcttcaatt ataatgggta atctgaacaa aagcataaat gaattgcaaa
    19441 atacaaataa aaaactatct gaacagtata aggaattagt gactattgat agtgaaactg
    19501 gacttagaaa tttaaagatt ttttataatg atgtaaatat ggagataagt aaatctatta
    19561 gacataatac tgatttttct cttatgatag taaaattacc atactacgga aacctacaga
    19621 ctatatttgg tgaaaacaaa actaataaaa tagtaaaata tattggttca aatattatag
    19681 aatgtacaag aaatgaagat ataatttata gtttacaaaa agatatgata gggatactaa
    19741 tgccaaatac atctttggaa ggttcaaaag ttgttaaaga cagaataaag aaaaggataa
    19801 aagaattaaa tttagattta aacaataggg gaaaatatgt aaatatagat gtcaaaattg
    19861 catttttaca atataagagt agttttggag atagtataaa ttttaagaat atagttgaag
    19921 aggaacttca atatgatgtt taaaatattt aataaaagtc tattaaaatt agtagttgta
    19981 ttatcaatag tactgacaat atcaaatttt agcttatctt catatgcatc agaaattact
    20041 tccagcacag ataaggtatt aatcatatat gattctaaga aagaaacagc ttataataga
    20101 gatattttaa atattatgag gactctattg ggaagattta gttcagatat agagctatta
    20161 aaattgagta actatgatgg tgagataaat aaaaattatt acagtcatat atttatttta
    20221 ggaatcaatg aaaactcata taataatgat aaaaacacta aaaacttgat tagttcctta
    20281 aattcatata aaggaactat atgttggtta ggatatggta tagaaaatct tttggaacat
    20341 aaaaaataca atttagacta tgtaggaaaa acaaacaata tagttagtgt aaattataga
    20401 ggtaaatcat ataacttgga tgaacattat gtttttaaca ttgtagaatc aaaagataca
    20461 agtaataaag taataggaag tattaatgat accttaaata agtatccata tataataaat
    20521 gataaaaatc ttttttatgt atcaaaatta gatttagatg gagttttatt ttatatattt
    20581 tgcgattcac ttaatgatat ttttaatatt aagacgtttg ataaaggacg tatatttgta
    20641 agaatagaag atgtacatgc ttttagagaa ccaaaaaatc ttgtagagat agcggattat
    20701 ttaagtagta agaatatacc atttacgatt gcattaatac cagcatatgt aaatcctaaa
    20761 aatcataagg taataacttt atcagaaagc cctgaaattg tcaaagcaat aaaatatatg
    20821 caagataaag gtggaactgt gatattgcat ggatatactc atcaatacaa gaaagaagaa
    20881 gtttctggag aagggtatga attttgggat ggtaaaaaag atgaaccctt aaaagaaaat
    20941 atgaagatat ttgtcaaaga tagagttttg aatggtctta gagtatgtat agagaatgga
    21001 atttatcctc ttgcatttga agcgccacat tatgcaatgg aatcagaggg atataaagaa
    21061 ttaaaaaaat atttttctac ttatatgggg caacatcaaa ataatgataa aaaatttagc
    21121 acaaatacat atccttatat tattagggat acagaggagt ttaatatatt tatacccgaa
    21181 aatttaggat atatagaccc agaagataag tttacttttc aaaatataaa agaaaattta
    21241 aataaattat ccattgtaag aggttttagt ggagggttct tctttcattc atatttaaac
    21301 atagagtatc taaaaaacac aatagaatat ttagaaaaac agaatataga atttatgaat
    21361 ttaagagatt ttaataattg ggtaaaagtt gatgaaatac aaataagaaa taatggagat
    21421 gaaattatag tcaactatga taaggactta gatgaaataa ctaaaagtga tactagattt
    21481 aaatccatat ccaatattag taaagtttta atattcatag tatctataag tgttttaata
    21541 tttgtgatta tatttatata ttttaagaga atagataaaa agaaattttt a
//
LOCUS       DAEPID010000069        21586 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.069, whole genome shotgun sequence.
ACCESSION   DAEPID010000069 DAEPID010000000
VERSION     DAEPID010000069.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 21586)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 21586)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..21586
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.069"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            137..3040
                     /locus_tag="KR257_002848"
     CDS             137..3040
                     /locus_tag="KR257_002848"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893559.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sigma 54-interacting transcriptional regulator"
                     /protein_id="HBH0031528.1"
                     /translation="MELRDKLVNIINTENKKDPLTDVQIAKFLSTTRENITNLRKELN
                     ISNSRQRRYPYLKSAISAILQKNKNISVSEITRELMTEGFNISRRVVEELLPKESLEM
                     DVVEESEEESNDPFETLIGNKGSLRNAVEQAKSAILYPPKGLPTLIIGESGVGKSLFS
                     RHMYEFAKQKKIVKESSNFVVFNCADYSDNPQLLLSLLFGYKKGAFTGAEYDTPGLVE
                     EADEGVLFLDEIHRLPPKGQEILFSILDRGKFRRLGETNAERKVSIMLIGATTENVET
                     NLLLTFRRRIPMLITLPPLHDRLLKEKIDLIYNIFQQECNRINAKIFVDKNVIEILAL
                     KKFSGNIGQLQNMIQVLCARAFMKFINSKDEDSESIVVVDINEVLKLKDSFKDAAFQE
                     IEYTEIRKYLKNAIFIPFNLEESSVKGSLLSDEYILPEDIYKTIEKKYYDLKSLDIED
                     IDIENILWTFILNRFADLKFNLDSNEEIFSMSDLNSFVSDSLVKLVKELMNDIVEKNM
                     NLEVNKNMFKYLAIHLEEAIKRIKLNQKIINVNLEKIKIDFSKEYEISKSFAIKIEES
                     IGIKIPDDEIGFITLYIKSALKNEVKKDKVGLIIISHGRIATETVNVVKELLGVKFPV
                     AIDMPLDEKPINIYNKAVELSKIIDQGKGILFLVDIGSLTNIGQIVNKRTNISTKTID
                     RVDLLMALEATRKVSMGEEELDEIFFSLLKDRMGYNYELEKHIDKSNAIVTLCLTGEG
                     TAKYISKTLEEKYDNTKCYQMSALDENLFCKIENLKETNNILAIVGTINPKIPGINFI
                     PYNKELFKNLDIYLSKSKQQDDRPVKSYERMLDEDLVIFEPDIYFKKDLLEYVCSILI
                     NKEYVEKDYLDSVLHREEMLPTYSKGAIGVPHGDSSTVNSTRFVFVKLKNPIDWGVGN
                     VNFIFMPVFQANDKEIVKNVLEILKDAEFMNNANKCFDKDAFRRIIFDKFKHL"
     gene            3073..3519
                     /locus_tag="KR257_002849"
     CDS             3073..3519
                     /locus_tag="KR257_002849"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430388.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIA"
                     /protein_id="HBH0031529.1"
                     /translation="MNVDLISLGLESNDYESVIEELGSIMCKKEYVKETYINAVLERE
                     RTLPTGLDIGEMCVAIPHTDSKHVNESNVAVGILKNPVKFNSMIDPKDRLDVELVFLL
                     AVKNPDSQVKLLKDLMSVFQNIKLLKNIKNASTKEEVAKLLDFIEI"
     gene            3642..3944
                     /locus_tag="KR257_002850"
     CDS             3642..3944
                     /locus_tag="KR257_002850"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430389.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIB"
                     /protein_id="HBH0031530.1"
                     /translation="MKQFNVLSVCGSGTVTSSMVAGKLKEVLGNKGISITTTEARPTE
                     ALNLAQSGRFDFITFTSPLQTGDYGIPTINAFACLTGIGEEAFFEEVLTVIEGIDK"
     gene            4125..5531
                     /locus_tag="KR257_002851"
     CDS             4125..5531
                     /locus_tag="KR257_002851"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454555.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS galactitol transporter subunit IIC"
                     /protein_id="HBH0031531.1"
                     /translation="MLEFMKSIIDTFGSAIIVPIIIFIIAKIFKVTTKKSFLSAVYAG
                     VALQGFTLILNSFTPIITPVINRMVESTGVNLPVFDVGWQATSLVAFSTSAGMIYLGL
                     GILLQTILFLIKWTDVFQPSDLWNNYSYMVWGAMVIGVTGNFPLGIACMVLLNLYSLL
                     ISELVAKRWSSYYRYPNCTIIAMHNVEASVFAVFADPIYNKLGLNKIKLNPKELEKKL
                     GFLGEPITLGLFLGMFIGILGNMTRINTMEAWGEIMKVGISTSAVMAIFPKVASMFAQ
                     AFAPITEAARKIMQKAGNREWYIAVNDAVGYGEPATLISGLILIPIMLVIAMVLPGNK
                     VLPVVDLLAIPYMVQGLVAIHNGNIPKVLVSGIIWFGLGLYVCTSTAPLFTDMATNIG
                     VAIPAGAMLITSFNILGKPLMGLVFFAFLSANPIYIGLSVVIYFVLWALFRKNKTSIL
                     DYLEKQALKNVEEEPVAV"
     gene            5875..6933
                     /locus_tag="KR257_002852"
     CDS             5875..6933
                     /locus_tag="KR257_002852"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012101107.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="galactitol-1-phosphate 5-dehydrogenase"
                     /protein_id="HBH0031532.1"
                     /translation="MGDKMRASVLYSVGDVRYEMVDIPEITDTQVLVNVKYVGICGSD
                     LPRSMVSGLSGNTKYPLILGHEFSGEVVKIGEKVKHINVGDRVAVAPLVPCGKCDYCN
                     EGNFGLCDDYNIIGTRVNGAFAEYVRVPEEHILKLPDTLDYETAAGIEPATIAYHGIS
                     KSNIRVGDSVVVLGCGPIGQFVIQWAKVFGASKIIAVDIFDEKLELSKLLGANYILNS
                     KEVNVIKEIKKITNGGADVVIETAGSRFTQEQSLFVAKKRGNIVFVGISHTELPLSAD
                     ATECILRGELTLKGSWNSYTSPYPGRAWTATLDFMGKGDIIFKPMISHKIGLNEVGDF
                     LSKMSKREINFNKILVEI"
     gene            7032..7718
                     /gene="araD"
                     /locus_tag="KR257_002853"
     CDS             7032..7718
                     /gene="araD"
                     /locus_tag="KR257_002853"
                     /EC_number="5.1.3.4"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729071.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="L-ribulose-5-phosphate 4-epimerase"
                     /protein_id="HBH0031533.1"
                     /translation="MLENLKEEVLKANLELPKKKLITYTWGNVSGIDREKGLVVIKPS
                     GVEYSNMTVEDMVVVDLEGNIVDGKLRPSSDTPTHLVLYKEFEELGGIVHTHSSWATI
                     WAQIGKSIPSCGTTHADYFYGSIPCTRKMTREEICNEYEKETGNVIIEEFMGRNPIHC
                     PGIIVNDHGPFTWGKDANEAVHNAVVLEEVAKMAYYTELMSPDNIMDKVLMNKHFSRK
                     HGKNAYYGQK"
     gene            7736..8383
                     /locus_tag="KR257_002854"
     CDS             7736..8383
                     /locus_tag="KR257_002854"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861507.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="class II aldolase/adducin family protein"
                     /protein_id="HBH0031534.1"
                     /translation="MLDSLKGKIVEIAIKAEHYGLCKEKTGNFSIRDKDTGYILITPS
                     GVGREELKVEHICVLDLDGNVIEVEKGIKPSSEVLMHIEIYKTRENINAISHTHSLYA
                     TAFSVAKKPIIPIVYESVNYGGYVDIAPYERPGTLKLAKSVSKLLIDTDACLLERHGL
                     TTVGNDLDEALLKSRYVEEVAEIYYRSLVLNQFKELEVVDVDEFKSWKYPEEIKF"
     gene            complement(8556..9923)
                     /locus_tag="KR257_002855"
     CDS             complement(8556..9923)
                     /locus_tag="KR257_002855"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893558.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sodium:alanine symporter family protein"
                     /protein_id="HBH0031535.1"
                     /translation="MNLIDILNKVDAFIWGPPLLVLLVGTGILLTVKLGVVQITKLPR
                     ALKLIFSAENKGSGDVSSFAALCTALAATVGTGNIVGVATAIKAGGPGALFWMWIAAF
                     FGMATKYSEGVLAIKYRTKDKNGQVSGGPMYYIVNGMGEKWRPLAIFFAISGILVALL
                     GIGTFTQVNSITDAINNSFGIDPRITGVVLAVFVALVVFGGLKSISNVATKIVPFMAV
                     IYVVICGIILISFWNKIPETFMLIIKSAFTPTAATGGFLGATMSLAIRNGIARGVFSN
                     ESGLGSAPIAAAAAKTEWPAEQGLISMTGTFIDTIIICTLTGFSLVISGVWCSDLNGA
                     VMTQAAFNGAIPTFGPILLTVSLTLFAFTTILGWSYYGERCFEFLFGVKGMNGYRTVF
                     VAMVLLGAFLKLEVVWIIADIVNGLMAIPNLIALLALSPIIVSETKKYFEHINSPENQ
                     IKKNA"
     regulatory      complement(10113..10201)
                     /regulatory_class="riboswitch"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00504"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="glycine riboswitch; Derived by automated
                     computational analysis using gene prediction method:
                     cmsearch."
                     /bound_moiety="glycine"
                     /db_xref="RFAM:RF00504"
     gene            10629..12749
                     /locus_tag="KR257_002856"
     CDS             10629..12749
                     /locus_tag="KR257_002856"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003440272.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA topoisomerase III"
                     /protein_id="HBH0031536.1"
                     /translation="MGKILVLAEKPSVGRDIAKVLGSKNEKNGYIEGPKYVITWALGH
                     LVTLADPESYGERYKSWSLEDLPILPKHLKTVVIKKSGKQFNTVKSQMNRNDIDEIVI
                     ATDAGREGELVARWIIEKSQVKKTIKRLWISSSTDKAIKDGFAKLRSGKEYENLYYSA
                     IARAEADWIIGINATRALTTKYNAQLSCGRVQTPTLAMLLKREEEIRNFKPKEYYGLE
                     LIATKGNSDIKFIWNDKNNNSSTFSKEKIESTLKKVKGVDIKISEVNKSYKKKYSPAL
                     YDLTELQRDANKMFGFSAKETLSIMQKLYEHHKVLTYPRTDSRYLTSDIVGTLKDRIK
                     AVNISDYSKTCNKLLKSNIIANKSFVDNSKVTDHHAIIPTEQKVFMSDFSDKERKIYN
                     LVVKRFLAVLSPPFEYEQTTISATVEGEIFKAKGNKVINLGWKESYKDIEDEDEYESI
                     PNILEKDVLKVKGLKITSGKTNPPPYLNEGTLLTAMEKNGLGTVATRADIIEKLFNSF
                     LMEKKNKDIYITSKGRQLLDLVPVDLKTPELTASWEKKLLDISKGKLSKNTFINDMKD
                     YSKDIVLEVKNSDNKFKHDNLTKNRCPECGKFMLEVNGKKGKMLICEDRECNTRKTIS
                     QVTNSRCPNCHKKLELRGEGEGRIFTCSCGYREKLSSFNKRKQEEKQKASKKDVNQYL
                     KNQNKNQETFNNPFAEALAKLKNK"
     gene            12853..14106
                     /locus_tag="KR257_002857"
     CDS             12853..14106
                     /locus_tag="KR257_002857"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729073.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flagellar protein FliS"
                     /protein_id="HBH0031537.1"
                     /translation="MDLSGIFKYYCKECENTWNNSSVELFENIETYSKDSQKKREKEL
                     DKLLNTISVHLERYPSDAVLRKMWVKKGEVFLQKTLEKENIFKLEKMDVEDRKKFLDI
                     TKQFIRDARKFDDDLPIGDIMQAMRNVWISNALQLLFGKEVYYSKANFAYSMLYPYTD
                     NYLDNTNIDKNDKILFNNWLEKRLLGEHIKSKDYHESKVSKMIDYIESVYPREKFTEV
                     YESLLLIFKSQVNSLKQHGKENHLCKEDLLSISIEKGGSSVLVDGYLISGLMTKEEIE
                     FCIGYGFLLQISDDLQDIKEDLKYNHKTIITEMSKEGTLDKVVNKLINFTIELIDSFK
                     INNKNKSVITMIKNDCLMLILFSVVYNAEFFSVGYIKEVEKFIPYTIDYSLEIEEKIK
                     EKFKNIDVLNNENEYKEMIDIICAE"
     gene            complement(14259..15320)
                     /gene="ytvI"
                     /locus_tag="KR257_002858"
     CDS             complement(14259..15320)
                     /gene="ytvI"
                     /locus_tag="KR257_002858"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890464.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sporulation integral membrane protein YtvI"
                     /protein_id="HBH0031538.1"
                     /translation="MDIQKQKNFIIKFTYVVLITSIVYIVLKFLLPLLMPFVISFIIA
                     SILRPIIRLITNNTNLNRTLISIVILLIFYGLCIFLLVSFGVKIFASVSDVFFRLPEI
                     YKSSIQPTLNTLFSKIDASTPNVNLALILGWDNISQSMMSLVASISTNALNAIASIAS
                     KTPAFMLKLIITLIASFFFTFDYQKIVNFILKQFPEKSQFMIINIKNSSINALLKLLK
                     AYAILLSVTFIELLIGLTILKVENAFTISVIIALVDILPVLGTGSILTPWMIISLING
                     NINLAIGLLILYIIITVVRQILEPKVVGHQIGLYPLITLMCMFVGAQLFGIAGLFGFP
                     IAATIIKNLHDNGIITAFK"
     gene            15594..16334
                     /locus_tag="KR257_002859"
     CDS             15594..16334
                     /locus_tag="KR257_002859"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890462.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tyrosine-protein phosphatase"
                     /protein_id="HBH0031539.1"
                     /translation="MKNFRDLGGNKTEDGRTVKKGLFYRSAKLSNLSENDIKILKELN
                     IKYIFDYRSDEEARKHPSTIISNIKNIRIPAMRELEESGGSFGSIEDMIDGLFEKDGA
                     FNMLNNSYYNLPINNPSYKKLVELIRDYSNLPILNHCTAGKDRTGVGSAIILMILGVS
                     RENIMKDYLKSNDFADKEIERFIEYKPKFKDIPKENLKYIFGVNEEYMKTAFRRIDEE
                     YISVEAYLYGEFNLNKEEIRKLRNQYLE"
     gene            16346..18124
                     /locus_tag="KR257_002860"
     CDS             16346..18124
                     /locus_tag="KR257_002860"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003440263.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcription antiterminator"
                     /protein_id="HBH0031540.1"
                     /translation="MSLNITARQINIIKILLNSKDTISGIALSQEIGCSSKTIQNEIK
                     DINKQLRNGKILSIRGVGYKLEGSFDEVNLNSNLYDDVDRVEYIIRKILTLSNEEKNT
                     IKLEDLADSMYVSVSTVKNDLKEVKRMLEKYSISVKSKHKQGICVLESEDKILNCIVD
                     LSNKRDNQLSLNDFLNDDIKERKLLIKKLLLDILNENGLVLTDIEFKSVLNNILVMLS
                     RHKYNEKEFIENYIENYRSKRSSILENEQNKEIIINSIKTFCKNLKLATSIDISNDKV
                     FEEFLYKHISSLCKKIKLGINQSPIMAQDIKIKYPFAFELANIAKKTIEKDLKIEINE
                     DEVANIALHIGGAVERASYNNKDKVFKTIIVCTSGIGTSMLIKAKLENIFKEKLEILK
                     IIPSYLVEYIKVIDVDFVISTVPIEVGDVPVINISPILSEKEIRLIEKYIETGNIYLD
                     LDIKSLFDSELFFTDLVFKRKEEVIDFMASKLVQKGYIDEDMKKSYFEREKIATTEIG
                     NMVTIPHGAIGKIFDNKIAIGILKKPISWEISDVRLIIMLALDKDKILDYEVIFSKIY
                     KRVDSIAKVISICENSSFEKFVNLFN"
     gene            18291..19208
                     /gene="pfkB"
                     /locus_tag="KR257_002861"
     CDS             18291..19208
                     /gene="pfkB"
                     /locus_tag="KR257_002861"
                     /EC_number="2.7.1.56"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890461.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="1-phosphofructokinase"
                     /protein_id="HBH0031541.1"
                     /translation="MIYTVTLNPSIDYIVKLDELKTGSTNRVKEEYVYPGGKGINVSR
                     ILKELGNDNTSLGFISGFTGEYIIRTLEEKELKTDFIKIKSGFSRINVKIKALKETEI
                     NGQGPNIDDEDIDTLYKKLDKLNQDDILILAGSIPSTLDEKLYENIMARLEKKNIKVV
                     VDATKNLLLNVLKYKPFLIKPNNDELEELFGVKLNSIEDMVKYARRLKEMGAINVLVS
                     MGKDGALLITEEDEVLISDVPKGKVKNSVGAGDSMVAGFISGYLNTGKYDYALKLGAA
                     SGSATAFSYDLAKREYIDKLVNEISVKKF"
     gene            19245..21164
                     /locus_tag="KR257_002862"
     CDS             19245..21164
                     /locus_tag="KR257_002862"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423248.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIA"
                     /protein_id="HBH0031542.1"
                     /translation="MKIIDLLDEKSIKLNLNSKTKSEAIEELVDLVANSGNLNDKENY
                     KKAILAREEMSTTGIGEGVAIPHAKNSSVTKACIAAAVSKEGIDYESFDGSLSNLFFM
                     IAAPDGANNTHLEVLSRLSTILMDEDFRNKLINSSSEKEFKEIIDKKEREKFSEEYQD
                     EKVAEKNIIDTKENDANKYPKVLAVTACPTGIAHTFMAAESLNKMAENKGVSIKVETN
                     GSAGVKNKLTKDEIENATCIIVAADKNVEMARFNGKKVIKTKVADGIHKAEELIDKAV
                     NGDAPIYHGGDGSHNESNEESESGFRKVYKHLMNGVSNMLPFVIGGGILIAIAFLLDD
                     YTINPSNFGSNTPIAAFFKGIGDKAFGFMLPVLAGYIAYSISDRPAFVVGFVGGALAG
                     DGGSGFLGALLAGFIAGYLVEGLKKIFSVLPASLEGIKPVLLYPLLGTLLMGIIMTFL
                     VIPPVTAINNAMVGFLNGLGGTSKIVLGLVLGGMMAVDMGGPVNKAAYVFGVASLESG
                     QFEIMAAVMAGGMVPPLAIALATTFFKNRFTKEERDSGKVNYVMGLSFVTEGAIPFAA
                     GDPLHVIPACVGGSAVAGALSMLFNAALRAPHGGVFVIPVVTHPFAYILAIAVGALVG
                     MMLLALLKKPLNQEV"
BASE COUNT         8676 a         2315 c         3775 g         6820 t
ORIGIN      
        1 caaaatgtaa atacttatca aaatgtataa atacttatga catctagtta cttacagggt
       61 ttaagtagaa aaaaatatca aagtaagtat ggcatgatag ttgcttatat atttatcaag
      121 aaaggagtta ttaagcatgg agttgagaga taaacttgta aacatcataa atacagaaaa
      181 taaaaaagat ccattaacag atgttcaaat agcaaagttt ttaagtacaa ctagagagaa
      241 cataactaat ttgagaaaag aacttaatat aagtaattca aggcaaagaa gatatcctta
      301 tttaaaatca gcaatttcgg caatattaca aaagaataag aatatttctg tatcagaaat
      361 tacaagggaa ttgatgacag aaggctttaa tatatctaga agagttgtgg aggaactttt
      421 acctaaagaa agtttagaaa tggatgtagt agaggaatct gaagaagaat cgaatgaccc
      481 atttgaaact ctgataggta ataaagggag tcttagaaat gctgtagagc aggctaaatc
      541 tgctatattg tatccaccaa aagggttacc aacgttgatt attggggaaa gtggagttgg
      601 taagagttta ttttctagac atatgtatga gtttgcaaag caaaaaaaga tagtaaaaga
      661 aagctccaat tttgttgtat ttaactgtgc tgattatagt gacaatccac aattattatt
      721 atctttgtta tttggatata aaaaaggtgc atttacaggt gctgaatatg atacaccagg
      781 tcttgtagaa gaagctgatg aaggagtttt atttttggat gaaatacata gattgcctcc
      841 aaaaggccaa gaaatactat tttctatttt agatagggga aagtttagga gattaggtga
      901 aactaatgct gaaagaaaag taagtattat gttgattggg gcaactactg aaaatgtaga
      961 gactaattta ttattaacat tcagaagaag gataccaatg ctaataactt tgccaccatt
     1021 acatgataga ttactaaaag agaaaataga ccttatatac aatatctttc aacaagagtg
     1081 taatagaata aatgcaaaaa tatttgtaga taaaaatgtg attgaaatac ttgcactaaa
     1141 aaagtttagt ggaaatatag gacaattaca aaatatgatt caggttcttt gtgcaagagc
     1201 ttttatgaag tttataaatt ccaaagatga agatagtgaa tcgatagtag tagtagatat
     1261 aaatgaagtt ttaaagctta aagattcttt taaagatgct gcctttcaag agattgaata
     1321 tacagagata agaaaatatt tgaaaaatgc tatatttata ccatttaatt tagaagaatc
     1381 atcagtaaaa ggaagtcttt taagtgatga atatatatta ccagaggaca tatacaaaac
     1441 aattgaaaag aaatattatg acctaaaatc cctagacatt gaagatatag atatagagaa
     1501 tattttatgg acttttattt taaatagatt tgctgactta aagtttaatc tcgatagtaa
     1561 tgaagaaatt ttttcaatga gtgatttaaa tagttttgta agtgatagtt tagttaaact
     1621 ggtaaaagaa cttatgaatg atatagttga aaaaaatatg aatttagaag taaataaaaa
     1681 tatgttcaaa tatctagcaa tacacttaga agaagctata aaaagaatta agctaaatca
     1741 aaagataata aatgtaaatt tagaaaaaat aaagattgac ttttcaaaag aatatgaaat
     1801 tagtaaaagt tttgcaataa aaattgagga atcaattggt attaagattc cagatgatga
     1861 aattggattt ataacactct acataaagtc tgctctaaaa aatgaagtga aaaaagataa
     1921 agtagggtta ataataattt ctcatggacg tatagctaca gagactgtaa atgtagttaa
     1981 agaactttta ggtgtaaagt ttcctgtggc tatagatatg cctttagatg aaaaaccaat
     2041 aaatatatac aataaggcag tagaactgtc aaaaataata gaccaaggga aaggcatatt
     2101 gtttttggtg gatattggtt cacttacaaa cataggtcaa atagtaaata agagaaccaa
     2161 tataagcact aaaactattg atagagtaga cctcctaatg gcactagaag caactagaaa
     2221 agtttctatg ggagaggaag aacttgatga aatatttttt tctttgctaa aagataggat
     2281 gggatataac tatgaattag aaaaacacat agataaatca aatgcaattg taacattatg
     2341 tcttactgga gaaggaactg ctaagtatat aagtaaaacg ttggaagaaa agtatgataa
     2401 cactaaatgt tatcaaatga gtgcattgga tgaaaattta ttttgtaaaa ttgaaaatct
     2461 aaaagagaca aacaatatat tagctattgt tgggacaata aaccctaaga taccaggtat
     2521 aaattttata ccctataata aagaactttt caaaaatttg gatatctatc tatcaaaatc
     2581 aaaacaacaa gatgacagac cagttaaatc gtatgaaaga atgcttgatg aggatttagt
     2641 gatttttgaa ccagatatat attttaaaaa ggatttatta gaatatgtat gttcaattct
     2701 tataaataaa gaatatgtag aaaaagatta cttagattct gttttacata gagaagaaat
     2761 gcttccaaca tattctaaag gagctatagg tgtgcctcat ggagattctt ctactgtaaa
     2821 tagtacaagg tttgtttttg ttaaactaaa gaatcctatt gattggggtg taggtaatgt
     2881 aaatttcata tttatgccag tttttcaggc taatgataaa gagattgtta aaaatgttct
     2941 tgagatacta aaagatgcag aatttatgaa caatgccaat aagtgttttg ataaagatgc
     3001 ttttagaagg attatatttg ataaatttaa acatctgtag ccatagcaaa aaaattgaga
     3061 ggagttagag taatgaatgt agatttaata tcattgggtt tagaatctaa tgattatgaa
     3121 agtgttattg aagaattagg aagtataatg tgtaaaaaag aatatgtaaa agaaacatac
     3181 ataaatgctg tcttggaaag agaaaggaca ttaccaacag gtctagatat tggagaaatg
     3241 tgtgttgcta ttccacatac agattcaaag catgtaaatg agtctaatgt agctgtaggg
     3301 atattgaaaa atcctgtaaa gtttaattca atgatagacc caaaagatag acttgatgta
     3361 gaacttgtat ttttattagc agtaaagaac ccagattcac aagtaaaact gttaaaggat
     3421 ttaatgtcag tttttcaaaa tataaagtta ttaaaaaata taaaaaacgc atcaacaaaa
     3481 gaagaagtag ctaaattatt ggattttata gaaatttaat gtaggagaat tttataaata
     3541 aaaaattaaa atttaaacaa tcaaagtaag tattattttt ttaataggtt taatcttata
     3601 taaaataaaa atttagagtg aaaaattagg aggaaattat tatgaaacaa tttaatgtat
     3661 tatcagtttg tggttcaggg acagttacat catctatggt agcaggtaaa ttaaaagaag
     3721 tactaggtaa taaggggatt tctattacta caacagaagc tagaccaaca gaagcactaa
     3781 atttagcaca atcaggaaga tttgacttta taacatttac gagtccactt caaacaggcg
     3841 attatggaat accaactata aatgcatttg cttgcctaac tggtataggg gaagaggcat
     3901 tctttgaaga agttttgact gttattgaag ggatagataa gtaagttttg gagacgtgaa
     3961 tttatagtat ttaaatcaat gatttagata ctataataag ctaatattaa ctaaatattt
     4021 gtggaaaaaa cattttatat gttgtcataa attaaaaaat tataaaaata gtcacttaag
     4081 tattaaatta agcttataaa tatttataag taggagggaa aaagatgtta gaatttatga
     4141 aatctataat cgatacattt ggttctgcaa ttatagttcc aattataata ttcataatag
     4201 caaagatatt taaagtaact actaagaaat cgtttctttc tgctgtgtat gcaggagttg
     4261 ctttacaagg ttttacactg attttaaatt catttacacc aataataaca ccagttatca
     4321 ataggatggt tgagagtaca ggagtaaacc taccagtttt tgatgttggt tggcaagcaa
     4381 catcattggt tgcattttca acaagtgcag gtatgatata tttaggtctt ggtatattat
     4441 tacaaacaat tttatttttg ataaaatgga cagacgtgtt tcaaccatca gatttatgga
     4501 ataactattc ttatatggta tggggagcaa tggttatagg agtaacagga aattttcctt
     4561 taggtatagc atgtatggtt ttattaaacc tatatagttt attaatatca gagttagttg
     4621 caaagagatg gtctagttac tatagatatc ctaattgtac aataatagct atgcataatg
     4681 ttgaagcttc tgtgtttgca gtatttgcag accctatata caataaattg ggattaaata
     4741 aaataaaatt aaatccaaaa gaattagaga agaaattagg gtttttaggt gaaccaatta
     4801 ctttaggtct ttttttaggt atgtttatag gtatattagg taatatgacg agaataaata
     4861 ctatggaagc ttggggagaa ataatgaaag taggtatatc tacaagtgca gtgatggcaa
     4921 ttttccctaa agtagcaagt atgtttgctc aagcatttgc acctataaca gaagcagcta
     4981 gaaagattat gcaaaaagct ggaaaccgtg agtggtacat agcagtaaat gatgctgttg
     5041 ggtatggtga acctgcaact ttaatatcag gtcttatatt aattccaata atgcttgtaa
     5101 tagctatggt acttcctggt aataaggtat taccagttgt ggatttattg gcaattccat
     5161 atatggttca aggtttagtt gccatacata atggtaatat accaaaagta ttggtttcag
     5221 gtataatttg gtttggatta ggattatatg tttgtacatc tacagcacca ttatttacag
     5281 atatggctac aaatataggt gtagctatac ctgcaggagc aatgttaata acaagcttta
     5341 atatactagg aaaacctttg atgggattag ttttctttgc atttctaagt gcaaatccaa
     5401 tttatatagg tctttcagtt gtaatttact ttgttctatg ggcattgttt agaaagaaca
     5461 aaacaagtat tcttgattat ttagaaaaac aagcacttaa aaatgtagaa gaagagcctg
     5521 tagcagttta agtttataaa aatgaaataa gaataattaa aggagtttat aattgatttt
     5581 atataagtat cagataatac ctgagaaata tttaaatgaa atatagactt ctttttattt
     5641 gataatattt gtaattataa tgcattgtat ctttatagtt gagttttctg tataacctgc
     5701 tatttaaaac atactctttt atatttatac agtaatgtgg tttaatttta taaaatgtaa
     5761 tctctactgg taaaagactt tgtatataag gcatttgcct gaataaacca tttatctttt
     5821 gtatggcata gatattgcta tatagaagta tatagcatga aaggagatat ttatatggga
     5881 gataaaatga gagcatcagt attgtatagt gtaggtgatg tcagatatga aatggtagat
     5941 ataccagaaa taacagatac gcaagtgctt gtaaatgtaa aatatgttgg gatatgtggt
     6001 tcagatttac ctaggtctat ggtaagtggt ttgagtggaa atacaaaata tccattgatt
     6061 ttaggacatg aattttctgg cgaagttgtt aaaattggag aaaaagtaaa gcatattaat
     6121 gtaggagata gagtagctgt tgcaccatta gtaccttgtg gaaaatgtga ttattgtaat
     6181 gaaggtaatt ttggcttgtg tgatgattac aatataattg gaacaagagt aaatggagcg
     6241 tttgcagaat atgtaagagt tccagaagaa catattttaa aactaccaga tacattggat
     6301 tatgaaactg ctgccggaat tgaaccagca actatagctt atcatgggat ttcaaagtct
     6361 aatattagag taggagatag tgtagttgtg ttaggatgtg gtccaatagg tcagtttgtt
     6421 atacaatggg caaaggtgtt tggtgcatct aagattatag cagttgatat ttttgatgaa
     6481 aaattagaac tttctaaact tctaggagca aactatatac ttaactcaaa agaagtaaat
     6541 gtaatcaaag aaataaaaaa aataacaaat ggtggtgctg atgttgtaat agagactgct
     6601 ggtagccgat ttacacaaga acaatctcta tttgtagcaa aaaagagggg aaatatagtg
     6661 tttgtaggta tatcacacac agaattacca cttagtgcag acgctactga gtgtatatta
     6721 cgtggagaac ttaccttgaa aggttcttgg aattcatata caagccctta tcctggaaga
     6781 gcatggactg caacattgga ttttatggga aaaggtgaca ttatttttaa acccatgatt
     6841 tcacataaaa taggtcttaa tgaagtgggt gactttttaa gtaaaatgag caagagagaa
     6901 attaatttca ataaaatcct agtagaaata taaaaattta ataaaaaatt ctaaaagcaa
     6961 ttaaatttta taactatgac attaaataaa ataaaaataa ttttcttaaa taaaatatag
     7021 gaggaagaaa agtgttagaa aatttaaaag aagaagtatt aaaagcaaac ttagaattac
     7081 ctaagaaaaa gctaattact tatacttggg gaaatgtaag tggaatagat agagaaaaag
     7141 gattagtggt gataaagcca agtggtgtag agtatagtaa tatgactgta gaagatatgg
     7201 ttgtagttga tttagaggga aatatagttg atggcaaatt aagaccttct tcagataccc
     7261 cgactcatct agttttatat aaagagtttg aagaattggg gggaatagta catacacatt
     7321 caagttgggc aacaatttgg gctcaaatag gaaaatctat accatcttgt ggtactactc
     7381 atgcagatta tttttatgga agtataccat gtaccagaaa aatgactaga gaagaaattt
     7441 gcaatgaata cgaaaaggaa actggaaatg taatcattga agaatttatg ggaagaaatc
     7501 caattcattg tccaggaata attgtaaatg accacggacc ttttacatgg ggaaaagatg
     7561 caaatgaggc tgtacacaat gcagtagttt tagaagaagt cgcaaagatg gcttattata
     7621 cagagttaat gagtcctgat aatattatgg ataaggttct tatgaataag catttttcaa
     7681 gaaaacatgg aaaaaatgca tactatggtc aaaaatgatt atctggaggt gaattatgct
     7741 agactcttta aaaggtaaaa ttgtggaaat agcaattaaa gcagagcatt atggtttatg
     7801 taaagaaaag actggtaatt ttagtattag agataaggat actggatata tacttataac
     7861 cccatcaggt gtaggaagag aagaattaaa agttgaacat atttgtgtat tggatttgga
     7921 tggaaatgta atagaagttg agaaaggtat taagccaagt agtgaggtat tgatgcatat
     7981 tgaaatatac aaaacaagag aaaatataaa tgccatatca catactcatt ctttatatgc
     8041 aacagcattt tcagtagcaa agaaaccaat tataccaatt gtatatgaat cagttaatta
     8101 tggcggttat gtagatattg ctccatatga aagaccagga actttaaaat tagctaagag
     8161 tgtttcaaaa ttactgatag atacagatgc atgcttatta gaaagacatg ggttgacaac
     8221 tgtaggtaat gatttagacg aagcattatt aaaatcaaga tatgtggaag aggtagcaga
     8281 aatatactat aggtctttag tattaaatca atttaaagaa cttgaagtag tagatgttga
     8341 tgagtttaaa tcttggaaat acccagaaga aataaagttt taatctaaat aattttcatt
     8401 gaagtggtta attaaaatat atgtattatt tatatcaatt actatgtttt attatgttaa
     8461 ttaccgtatt ttgcaaatat atttattaca ttttttcaaa aaaatataga atccgaaagc
     8521 catataaaat tgacttggga ttctatactt tttatttatg catttttctt tatctgattt
     8581 tctggagaat ttatatgttc aaaatatttt ttagtttcag atactattat aggtgataat
     8641 gcaagtaaag ctataaggtt aggtattgcc ataagcccat ttacaatatc agcaattatc
     8701 caaacaactt ctaactttaa gaaagcacct aataacacca tagccacaaa tacagttcta
     8761 tacccattca tgccttttac accaaacaga aattcaaaac atctttctcc ataataactc
     8821 catcccaaaa ttgtagtaaa tgcaaataat gttaaactaa ctgtaagtaa tattggtcca
     8881 aatgtaggaa ttgctccgtt aaaagctgct tgtgtcataa cagctccatt taggtctgaa
     8941 caccacactc ctgaaataac aagagagaat ccagtaagag tacagattat aatagtatct
     9001 ataaaagtac ctgtcataga tataagacct tgttccgctg gccattcagt tttagcagca
     9061 gcagcagcta ttggagcact acctagacca gactcatttg aaaatacacc acgagcgata
     9121 ccatttctaa ttgccagtga catagttgct cctaaaaaac caccagtagc agcagtaggt
     9181 gtaaatgcac ttttaattat taacataaaa gtttcaggga ttttattcca aaaagatatt
     9241 aaaatgattc cacagattac aacatatata actgccataa aaggtactat tttagtagct
     9301 acattagata tacttttaag tcctccaaat acaaccaaag ctacaaatac tgctaataca
     9361 acccctgtaa ttctagggtc tatcccgaaa ctattattta ttgcatctgt tattgaattt
     9421 acttgagtaa aagtaccgat tcctaaaagt gcaactagta taccacttat agcgaaaaat
     9481 attgcaagag gtctccattt ttctcccata ccatttacta tgtaatacat tggcccacca
     9541 gacacttggc catttttatc tttagttctg tattttattg caagaacacc ttctgaatac
     9601 ttagtagcca ttccaaagaa tgctgctatc cacatccaaa aaagtgcacc aggtccacca
     9661 gctttgatag ctgtagcaac accaacaata ttaccagtac caactgtagc agctagagca
     9721 gtacataagg ctgcaaaact tgaaacatca ccactacctt tgttttcagc agagaatatt
     9781 aacttaagag ctcttggcag tttagttatt tgaacaactc caagcttaac agtaagtagt
     9841 ataccagtac caactaatag taccagtagg ggtggtcccc aaataaaagc atcaactttg
     9901 tttaaaatat caattagatt cataaaaaca ctccctcatt ttttttgctt tacataatca
     9961 atagaatttt taatgaagta attgacagga aataagtata atttattaat aatttctagt
    10021 gtaataaaaa aagctaaatc taaaaaagat tcagctctgg atgtacacta attagcaacc
    10081 aaaataaaag tattagtaaa tactgttttt ggtagataat ccctgtcctt ttgcctgaga
    10141 gattgagcat aaaagccttg ccccttcggc gcccataatg ggtctctcca gagttccgta
    10201 aattttacag tcctactttt aaaagtacct gagagtgtta ctccttcggt gtgctatata
    10261 gcaactcttc tataaaatct taaccggata ttgatttgtc atagcttatt gtattaataa
    10321 tattaatata agtttttatg ttttgtcaac taaaaaatta aaaaacaaag aaaaaatata
    10381 aaaatgtaag cctatttacg aattataaac ttagaaagat gagtaatata cgtgaaaatg
    10441 aattttgtaa tacacataca aatgaagtgt aaaataagtt ctaaataaaa aaataataaa
    10501 atcttaaata attaattaga tatgattaaa ttatggtaat attatagtta cgatattaag
    10561 aaaagttcta tttagttaga ttttaagcgt aatatgagat tatgtataga gaaaggatgt
    10621 atttttagat gggaaaaata ttagtgctag cagaaaaacc ttctgttgga agagatatag
    10681 caaaagtttt agggtcaaaa aatgaaaaaa atggttatat agaggggcca aagtatgtga
    10741 taacttgggc actaggtcat ttggttacac ttgctgaccc cgaaagttat ggagaaagat
    10801 ataaatcatg gagcttagaa gacctgccaa tacttcccaa gcaccttaag actgttgtaa
    10861 taaaaaagag tggaaagcag tttaatacag ttaaatcgca aatgaataga aatgatatag
    10921 atgaaatagt tatagcaaca gatgcaggtc gtgaaggaga acttgtagca aggtggataa
    10981 tagaaaaatc acaggtaaaa aaaactataa aacgtctttg gatttcttca agtacagaca
    11041 aagcaataaa agacggattt gcaaaattaa gaagtggaaa agaatatgaa aatttgtatt
    11101 actcagcaat agcacgagca gaagctgatt ggattattgg aataaatgca accagagctt
    11161 tgacaacaaa gtacaatgca cagctttctt gtggaagagt acaaactcct actcttgcaa
    11221 tgttgcttaa aagagaagaa gaaataagaa atttcaaacc taaagagtat tatggattag
    11281 aattaattgc tacaaaggga aattcagata taaaatttat ttggaatgat aaaaacaata
    11341 attcttcaac ttttagtaaa gaaaagatag aatccacatt aaaaaaagta aaaggtgtag
    11401 acataaaaat atctgaagta aacaagtcat ataagaaaaa atattcacct gcactctatg
    11461 atttaacaga attacaaaga gatgcaaata aaatgtttgg attttcagca aaagaaactt
    11521 tatctataat gcaaaaactg tatgaacatc ataaagtact tacttatcct agaactgatt
    11581 ctagatattt aacatcagat attgttggaa cattaaaaga tagaataaaa gctgtaaata
    11641 ttagtgatta ttcaaagact tgtaataaat tattaaaaag caatattata gctaataaat
    11701 cgtttgttga caattcaaag gtaacagacc atcatgcaat aataccaaca gaacagaagg
    11761 tattcatgag tgattttagt gacaaagagc gaaaaatata taatcttgta gtaaaaagat
    11821 ttttagcagt actatctcct ccttttgaat atgagcagac aactataagt gcaactgtag
    11881 aaggagaaat atttaaggct aagggaaaca aagtaataaa tttaggttgg aaagaaagtt
    11941 ataaagatat tgaagatgaa gatgagtatg aaagtatacc aaatatttta gaaaaagatg
    12001 tacttaaggt caagggatta aagataactt caggaaaaac aaatccacca ccatacttaa
    12061 atgagggaac attattgact gctatggaaa agaatggtct agggacagtt gctacaagag
    12121 cagatataat agaaaaatta ttcaattcat ttttaatgga aaagaaaaat aaagatatat
    12181 atataacatc aaaaggaaga caattattag atttagttcc agtagactta aagacaccag
    12241 aacttacagc ttcatgggaa aagaaattat tggatatttc aaagggaaaa cttagtaaaa
    12301 atacattcat aaatgacatg aaagattatt caaaagatat tgtactagaa gtaaaaaata
    12361 gtgataataa atttaaacat gataacttaa ctaaaaatag atgtccagaa tgtggtaaat
    12421 ttatgttaga ggtaaatggt aaaaaaggta agatgttgat ttgtgaagat agagagtgta
    12481 atactagaaa aactatatca caagtaacca attcaagatg tcctaactgc cataaaaaat
    12541 tagaacttcg tggagaaggt gaggggagaa tcttcacttg tagttgcgga tacagagaaa
    12601 agttgtcgtc tttcaacaag agaaagcaag aagaaaaaca gaaggcatca aaaaaagatg
    12661 ttaatcaata tttaaaaaat caaaataaaa atcaagagac atttaataat ccatttgcag
    12721 aagcattagc taagctaaaa aacaaataat tttaaagtta ttattataca caattataac
    12781 tttaactgta tattagttat atgtactgat ataatatagt gtatagttta ggcatgaaag
    12841 tagggctgtt aaatggattt aagtggcata tttaaatact attgtaaaga gtgtgaaaat
    12901 acatggaata attcgagtgt tgaattattt gagaatatag aaacgtatag taaagattca
    12961 caaaaaaaga gggaaaaaga attagataaa ttgctaaata caatatcagt tcatttagag
    13021 aggtatccaa gtgatgctgt attgagaaaa atgtgggtaa aaaagggcga ggttttctta
    13081 caaaagacat tggaaaaaga aaatattttt aagttagaaa aaatggatgt agaggataga
    13141 aaaaaatttt tagatataac aaaacagttt attagagatg ctagaaaatt tgatgatgat
    13201 ttacctatag gtgatattat gcaagctatg aggaatgtat ggatttcaaa tgcattacaa
    13261 ttattatttg gtaaagaagt atattattca aaagctaact ttgcatatag tatgttatat
    13321 ccatatactg ataattattt agacaataca aatatagata aaaatgataa gattttattt
    13381 aataactggt tagaaaaaag gctcctggga gaacacatta aatctaagga ttatcatgaa
    13441 agtaaagtat ctaaaatgat agattatatt gaaagtgtat accctagaga aaagtttaca
    13501 gaagtttatg aatcgttatt attaatattt aaaagtcaag taaatagttt aaaacaacat
    13561 ggtaaggaaa atcatttgtg taaagaagat ttattatcca tttctattga aaaaggaggt
    13621 tcatccgttt tagtagatgg atatttaata agtggattga tgacaaagga agaaatagag
    13681 ttttgtatag gatatggatt tttattacaa atatctgatg atttacaaga tataaaagaa
    13741 gatttaaaat acaaccataa aactattatt acagagatgt caaaagaggg tactttagat
    13801 aaagttgtaa ataaactaat aaattttact attgagttaa tagatagttt taaaattaat
    13861 aataaaaata aatctgtaat aactatgata aagaatgatt gcttaatgtt aattttattt
    13921 tctgtagttt ataatgctga atttttttct gtaggatata taaaagaagt agagaaattt
    13981 attccatata caatagatta ttcattagag attgaagaaa aaataaaaga aaaatttaaa
    14041 aatatagatg ttttaaataa tgaaaatgaa tataaagaaa tgattgatat tatttgtgca
    14101 gagtagaaaa aaagggagtg tcttagaata gactttttag tttatgaggc actctttttg
    14161 tataaaatca aatgtatttt catcatttta ataattaaaa agagcttatc cctatttgag
    14221 aaagcccttt ttaatttaat aaaaatgtca aggttaaact atttaaatgc agtaataatc
    14281 ccattatcat gtaagttttt tatgattgta gctgcgatag ggaatccaaa taatccagct
    14341 attccaaata gttgagctcc aacaaacata cacattaatg ttattaaagg atataggcca
    14401 atttggtgtc ctactacctt tggttctaat atttgtctaa caacggttat aattatgtat
    14461 agtattaaaa gtcctattgc taaattaata tttccattaa tgagtgagat aatcatccaa
    14521 ggtgtcaaaa tacttcctgt acccaagact ggcaaaatat caacaagtgc tatgatgaca
    14581 gatatagtaa atgcattttc aacctttagg atagtaagtc caataagtag ttctatgaat
    14641 gtcactgata gtagtattgc ataggctttt agtagtttta aaagagcatt aatactgcta
    14701 ttttttatat ttattatcat aaattgactt ttttctggaa attgttttaa gataaagttt
    14761 actatttttt gatagtcaaa agtaaagaaa aaagaagcaa ttaaagtaat aataagtttt
    14821 aacataaatg caggtgtttt acttgcaata ctagcaatag cattgagtgc atttgttgaa
    14881 atagaagcta ctaaagacat catagattga cttatattat cccaaccaag tattaatgct
    14941 aggttaacat taggtgtact agcatctatc tttgaaaata aagtatttag cgttggttgt
    15001 atacttgatt tatatatttc aggaagtcta aaaaatacat cacttacact tgcaaatatc
    15061 ttcacaccaa agctaactaa taaaaatata cacaacccat aaaaaattaa aagtattact
    15121 atagaaataa gtgtacgatt taaatttgta ttatttgtaa taagtcttat aataggtctt
    15181 aagatggatg caatgataaa actgattaca aaaggcatta ataatggcaa taagaatttt
    15241 aatacaatat atacaatact tgttattaaa actacatatg taaatttaat tataaaattc
    15301 ttttgctttt gaatatccat aatataaaac ctccaatgta tttgatatta ttctaaatat
    15361 ggtctttttt acagaaaata tactactgta tattgattat aaactataaa gcttatgtaa
    15421 agtaaataaa ttatgtaaaa tttaggttaa ttttgtataa agagatactt ttatatttta
    15481 caattaataa ccaaatacta aaaaatattt taaataaaga acttaaaatt gtgataaaat
    15541 taatttatag atattaaaaa aagtataata tatggttttt aagaggtgct aagatgaaaa
    15601 attttagaga tttaggtggg aacaaaactg aggatggcag aactgtaaag aagggattat
    15661 tttataggtc tgcaaaatta tcaaatctaa gtgaaaatga tataaagatt ttaaaagagt
    15721 taaatattaa atatatattt gattatagaa gtgatgaaga agctcgtaaa catccatcaa
    15781 caataatatc aaatataaaa aatataagaa taccagcaat gagagagcta gaagaatcag
    15841 gaggaagttt tggttctatt gaagatatga ttgatggatt gtttgaaaaa gatggtgcat
    15901 ttaatatgtt aaataatagt tactataatt tgcctataaa taatccgtca tataaaaaat
    15961 tagtagaact tataagagac tattctaatt taccaatatt aaatcattgt acagctggta
    16021 aggatagaac tggtgtgggg agtgctataa ttcttatgat tttaggggta tcgagagaga
    16081 atataatgaa agattatcta aaaagtaatg attttgcaga taaagagata gaaagattta
    16141 tagaatataa gcctaaattt aaggacattc caaaagaaaa tttgaaatat atatttggtg
    16201 taaatgaaga gtatatgaaa actgcattta gaagaattga tgaagaatac attagtgtag
    16261 aagcatattt atatggagaa tttaatttaa ataaagaaga aataagaaaa ttaagaaatc
    16321 aatatctaga gtaaaaggtg agtttatgag tttaaatata acagcaagac agataaatat
    16381 aataaaaata ttgttaaatt caaaagatac aattagtggt attgccttaa gtcaagagat
    16441 aggatgttct tcaaaaacta tacaaaatga aataaaggat attaataaac aacttagaaa
    16501 tggtaaaatt ttgtcaataa gaggagttgg ttataaacta gaaggaagtt ttgatgaggt
    16561 aaatctaaat agcaatctct atgatgatgt agatagagta gaatatataa tcagaaaaat
    16621 attaacctta agtaatgaag aaaaaaatac tataaaactt gaagatttag ccgattctat
    16681 gtatgtaagt gtttcaacag taaaaaatga tttaaaagaa gtaaaaagaa tgttggaaaa
    16741 gtattcaata tcagttaaat ctaagcataa acaaggtata tgtgttttag aaagtgaaga
    16801 taagatatta aattgtatag ttgacttaag caataagaga gataatcaat tgagtttaaa
    16861 tgatttttta aatgatgata taaaggaaag aaaactatta ataaaaaaat tattattaga
    16921 catattaaat gaaaatggat tagtattaac tgatatagaa tttaagagtg tgttaaataa
    16981 tatattagtt atgttaagca gacataagta taatgaaaaa gaatttatag agaattatat
    17041 agaaaattat aggagcaaaa gaagctcaat tttagaaaat gaacaaaaca aagaaattat
    17101 aataaattca ataaaaacat tttgtaaaaa tttaaaatta gctacatcaa tagatataag
    17161 taatgataag gtatttgaag agtttttata taagcatatt agtagtttat gtaaaaaaat
    17221 aaagttaggt ataaatcaat cacctataat ggctcaagat ataaaaataa aatatccatt
    17281 tgcttttgaa ctagctaata tagctaaaaa gacaatagaa aaagatttga agatagaaat
    17341 taatgaagat gaagttgcaa acatagctct acatatagga ggagcagttg aaagagcatc
    17401 ttataataat aaagataagg ttttcaaaac tataatagtt tgtacttcag gcataggcac
    17461 atcaatgtta ataaaagcta aattagagaa tatatttaag gaaaaattag aaatactaaa
    17521 gattattcct tcatacttag ttgaatatat aaaagttata gatgttgatt ttgtaatatc
    17581 tactgttcct attgaagtag gagatgtgcc agtaataaat atatctccaa ttttaagtga
    17641 gaaagaaatt agattaattg aaaaatatat agaaacagga aatatatacc tagatttaga
    17701 tataaaaagc ctgtttgata gtgaattgtt ttttactgat ttggtgttta aaaggaaaga
    17761 agaagttata gattttatgg caagtaaact tgtacaaaag ggctatatag atgaggatat
    17821 gaaaaaatct tactttgaga gagaaaaaat agcaacaaca gaaataggga atatggtaac
    17881 tataccacat ggagctattg gaaaaatttt tgataataaa atagcaattg gtatattaaa
    17941 gaagcctatt tcttgggaaa tatcagatgt tcgtttaata ataatgttag cccttgataa
    18001 agataaaata ttagattatg aagtaatatt ttcaaaaata tataaaagag tagattctat
    18061 agcaaaagtt ataagtatat gtgaaaatag tagttttgaa aaatttgtaa atttatttaa
    18121 ttagatgggt agtattgtat atacacctgt aaatttggat aatataaaac taaataagat
    18181 aaaaacgata aatttctctt ttaattaaga gaaatttttt gactttcaag gatattaata
    18241 taaagttaag atataaacat aaagcaaata aataaaaaag aggtggcaat atgatttata
    18301 cagtgacatt aaatccatca atagattata tagttaagct agatgagcta aagacaggaa
    18361 gtacaaatcg tgtaaaagaa gaatacgttt atccaggagg aaaaggtata aatgtatctc
    18421 gcatacttaa ggaacttgga aatgataata catctttagg ttttataagt ggttttactg
    18481 gagaatatat aataagaaca ttggaagaaa aagaattgaa gacagatttt ataaagataa
    18541 aaagtggttt ttcaagaata aatgtaaaaa taaaggcgtt aaaggaaact gagattaatg
    18601 gacaaggtcc aaatatagat gatgaagaca ttgatacttt atataaaaaa cttgataagc
    18661 taaatcaaga tgatatttta atattggcag gaagtatacc atctacttta gatgaaaaac
    18721 tatacgaaaa tataatggct agattagaaa aaaagaatat aaaagttgta gtagatgcaa
    18781 ctaaaaatct tcttcttaat gttttaaaat acaaaccttt tctaattaag cctaataacg
    18841 acgaattaga agaactattt ggtgttaaat taaattcaat tgaagacatg gtaaaatatg
    18901 ctagaaggtt aaaggaaatg ggagctataa atgtcttggt atcaatggga aaagatggag
    18961 cattgttgat tacagaggaa gatgaagtgc ttataagtga tgttccaaaa ggaaaagtaa
    19021 aaaattctgt aggagcaggt gattcaatgg tagcaggatt tatatctggg tatttgaata
    19081 ctgggaaata tgattatgct cttaaattgg gagcagcttc aggtagtgca actgcttttt
    19141 catatgactt agccaaaaga gaatacattg ataaattggt aaatgaaata tctgtaaaga
    19201 agttttaaaa tattaaaaaa tatatagaaa ggtaattaat atttatgaaa attatagatt
    19261 tattagatga aaagtcaatt aagttaaatt taaattcaaa aaccaaatca gaagcaatag
    19321 aagaattagt agatttggtc gcaaatagtg gaaatttaaa tgataaagaa aactacaaaa
    19381 aagcaatttt ggctcgtgaa gaaatgagta caacaggaat tggagaaggt gtagctatac
    19441 ctcatgctaa aaattcttca gttactaaag cttgtatagc agcagcagtg tcaaaagaag
    19501 gtatagatta tgaatcgttt gacggaagtt tatcaaatct attttttatg atagctgcac
    19561 cagacggagc taacaatact catcttgaag tattatcaag attatctaca atacttatgg
    19621 atgaagactt tagaaataaa cttataaatt caagctctga aaaagaattt aaggaaataa
    19681 tagataaaaa ggaaagagaa aaattcagtg aagaatatca agatgagaaa gtggctgaaa
    19741 aaaatataat agatactaaa gagaatgatg ctaataagta tcctaaggtt ttagcagtaa
    19801 cagcatgtcc aactggaata gcacatacat ttatggcagc tgaaagttta aataaaatgg
    19861 cagaaaacaa aggtgtatca ataaaagtag aaactaatgg ttcagcaggt gttaaaaata
    19921 agcttacaaa agatgaaata gaaaatgcaa catgtataat agtggcagca gataaaaatg
    19981 ttgagatggc tagatttaat ggcaaaaaag tcataaaaac taaggtggct gatggtatac
    20041 acaaagcgga agaacttata gacaaggctg taaatggaga tgctccaatt taccatggag
    20101 gagatggaag tcacaacgaa tcaaatgaag aaagtgaaag tggatttaga aaagtataca
    20161 aacacttaat gaatggtgta tctaatatgt taccatttgt tattggtgga gggatactta
    20221 tagcgatagc ctttttactt gatgattata ctattaaccc ttcaaacttt ggttcaaata
    20281 cacctatagc agcatttttt aaaggaatag gagataaagc ttttggattt atgttacctg
    20341 tacttgctgg atatatagca tactctatat ctgatagacc agcgtttgtt gtaggatttg
    20401 taggaggtgc tctagcaggt gatggtggtt caggcttttt aggtgcacta cttgcaggtt
    20461 ttatagcagg ttatttagta gaagggctta agaaaatatt tagtgtacta ccagcttcat
    20521 tggaaggaat aaaaccagta ttgttatatc ctttacttgg aacacttttg atgggaatta
    20581 taatgacatt tttagtaata cctccagtta cagcaattaa taatgcaatg gttggatttt
    20641 taaatggttt aggtggaact tcaaaaatag ttttaggatt agtattaggt ggaatgatgg
    20701 ctgtggatat gggtggacct gtaaataaag cagcatatgt atttggagtt gcatcacttg
    20761 aatcagggca gtttgaaata atggcagcag taatggctgg tggtatggtt ccgccacttg
    20821 ctatagctct tgcaactaca ttttttaaga atagatttac taaagaagaa agagattctg
    20881 gtaaagttaa ttatgtaatg ggattatcat ttgttactga aggagctata ccttttgcag
    20941 ctggagaccc acttcatgtt ataccagctt gtgttggagg ttcagcagtg gcaggagcac
    21001 ttagtatgtt gttcaacgca gctcttcgtg cacctcatgg aggagtattt gttataccag
    21061 tggttaccca tccatttgca tatatattag ctatagctgt aggtgctttg gttggaatga
    21121 tgcttttagc attacttaaa aaaccattaa atcaagaagt atagcaatta aaggatattc
    21181 aagaacttaa aatatgatgt tttataaaaa ttaatatatt gctgaattat tttaaaataa
    21241 ggattttatg aggctgttat ataacgattt gtaattgtta tcttgacagt cttttatttt
    21301 tatataagta aaataagtgt gttttgcttt atttgtattt aaattgtttt taagttagaa
    21361 tataaagaaa attatatatt attttaatat tcactcgaac tagaaaataa tatttgttgt
    21421 attttttgta tataaaaata tattgtaata ttaaaaaaat aatagtaaac tgattgcata
    21481 aaaatgattt ttatataaat tttaaacaga agaataaatt tctaacgaaa ttggatattt
    21541 cttctgtaaa tacatattca aaaaaagaat tataagagtt tagtca
//
LOCUS       DAEPID010000070        21540 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.070, whole genome shotgun sequence.
ACCESSION   DAEPID010000070 DAEPID010000000
VERSION     DAEPID010000070.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 21540)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 21540)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..21540
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.070"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            574..4707
                     /locus_tag="KR257_002863"
     CDS             574..4707
                     /locus_tag="KR257_002863"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014466370.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF11 domain-containing protein"
                     /protein_id="HBH0031543.1"
                     /translation="MATVSGQIVFDRNRSATIDSGDSGIANIPVVLQDIATGVRLVVL
                     TDASGNYVFTNVPNGNYRIVEAFGTTGGVPTPGNFATAIVGPVPIAEMPPISPPIGST
                     NLDGTTPNTLLITVAGSDITNQNILNGPVIYTPIENILDSCVSVSNINLITDADNGTF
                     GFFPPGTPSNTGPEIEPYPNVTPDFTYVVPDPTKFTPLDGEYTVQNIMTNAMSNVIGA
                     WWRIADHTTGNETGRMMVVNGFNPGAVFFKSTVQVTPNTNYLFSTWILNLFKVTGYPP
                     PQLGVRIFDQNNNILYQATLGAQIPVNTNAPEWKEVGTVINSQNNNQLTVEFFSEGES
                     AIGNDYAIDDVSLREIAVPTFTPIKTSNTETANVGDIITYTVTLDNTCDSPLTNVFFR
                     DLIPNGLEFIPGTVTVDGVSVPGVDPNTGFSLPDIGGGTGVEVTFDVVVESIPNPNPT
                     NNIANIDYSYTPVEGGIPNDFSVDSNPVPVEVISADIEVTKLSEPTIVNPGEELIYTI
                     KVVNNGPFPSENVVLTDDVPASIINPEYSLDGGVTFQPWTGSLNIGTLEVGETRVIII
                     RGIVNPSTVGIITNTAVVSSTTADPNLNNNTSTIETEVNLLADILVMKTAEPNSAVPG
                     TLLRYTIQVENLGPANAENVILNDDIPASIINPEYSLDGGASFQPWNGSLNIGTLNSG
                     ISLTVLIQGTVSLNSSEYIVNTATVSSTTPDPDLSNNISTIITPVNPQAGISIIKVAD
                     EDVAVPGEEFVYTIEIFNEGPSNATNVVLTDDIPDVILNPEYSLDGGATFQPWNGSLN
                     IGTVAPGQLIRIIIKGLVSSTATGDITNTAEVSADVPEPVTDSSTVTTPIVPSADIEV
                     IKTSNMDTAVPEETFSYTITVTNLGPSAAQSIVLTDDIPDVILNPEYSLDGGVTFQPW
                     NGNLSIGTLDAGEIRSIIIRGTVSQTAVGTIINTATISSPTPDPNPDNNTSTDETDIS
                     PLADISVIKGNEPVAIPGGRFIYGIEIANAGPSFAENVTLTDNIPASILNPEYSIDNG
                     VTFQPWNGSLNIGTLDAGEIRNIIIRGTVSQTAIGTIINTATVSSTTPDPNLNNNTST
                     SEAEVSSSADISVVKRSNQTVVVPGDVLDYTIEVRNAGPSTAQNVTLTDNIPASILSP
                     EYSIDNGVTFQPWNGSLSIGTLDAGEIRNIIIRGIVSQTAIGTIINTATVSSTTPDPN
                     PDNNTSTSEIDISSSADISVIKLANKTEACVGEQIDFVIVVSNAGPENAQNVTLIDNV
                     SDKLKKAVFSLDRGVSFQPWTGSLNIGTLPAGTLRVIILRGIIKSTCLDRLTNIAEVT
                     STTPDSNLNNNISRVQVEIKQFCCNDCGCKDCCCNCCCNDCGCKNCCCNCCKNDFWC"
     gene            5164..5511
                     /locus_tag="KR257_002864"
     CDS             5164..5511
                     /locus_tag="KR257_002864"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861374.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cupin domain-containing protein"
                     /protein_id="HBH0031544.1"
                     /translation="MHENKKNLLDGSLAQYNDTAVPKIPVFAGNDITSEVYYFKPNQV
                     LNAHRHPNGEQIFVFLKGEGKMKLGEHECDVKNGDTVFVPTGEWHEITNGSNEEMVAV
                     QITKINAGAEYRG"
     gene            complement(5661..6710)
                     /locus_tag="KR257_002865"
     CDS             complement(5661..6710)
                     /locus_tag="KR257_002865"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897038.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="HBH0031545.1"
                     /translation="MFKKIVAIASSIIVSTICLTGCDFNSNDKKDESSSSKNLDKVTI
                     AEVTHSVFYAPQYAAITKGFFEDEGIKIDLINTQGADKTMAALISGEANVGLMGPEAS
                     IYVYNQNKNDYAVNFAQLTKRDGSFLVARKKMPNFSYNDLKGTEILGGRKGGVPLMTF
                     EYVLKEKGLTIGENLKAGNVNVRTDVQFGVMAGAFAGGEGDFTTAFEPTATAMEKEGS
                     GYIVTSIGKDSGEIPFTAYSTTRSYMKNNKDLIQRFTNAVYKGQLWIQQASSKEVAKA
                     MQPFFEDISLEDLTTVVDRYKSIDAWSQNPVLKEEGLKKLMTVMKEAKELDKEAPYKD
                     IVNTEFANNAIKNIK"
     gene            7096..7830
                     /locus_tag="KR257_002866"
     CDS             7096..7830
                     /locus_tag="KR257_002866"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435476.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="HBH0031546.1"
                     /translation="MKQNKYDDDRFFNKYSKMERSTNGLAGAGEWHVLKKMLPDFKGK
                     RVLDLGCGFGWHCQYAVENGAISAVGVDISEKMLKEARNKTQLDNINYICMPIEDINF
                     PKDSFDVVISSLAFHYIQSFEDICKNISNCLSNKGNFVFSVEHPIFTAYGSQEWYCDK
                     DGNNLHWPVDRYFEEGVRRSNFLGEEVIKYHKTLTTYLNALMKTGFEILEIIEPQPEE
                     KLLDTIPDMKDELRRPMMLLVSAKKR"
     gene            complement(7973..8464)
                     /locus_tag="KR257_002867"
     CDS             complement(7973..8464)
                     /locus_tag="KR257_002867"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428667.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="prolyl-tRNA synthetase associated
                     domain-containing protein"
                     /protein_id="HBH0031547.1"
                     /translation="MNNQQQEVYKKLDELSIPYEAVNHPPVYTIEEMEELKTLHMEFV
                     VKNLFLRDAKGKEHFLVVLGKDKKADLKDIRQQIDSKPLSFASEERLQKYLKLTKGAV
                     TPFGILNDKEAVVKVVFDKDLLKMDKIGIHPNDNTATVFLKFEDMKKLIEENGNEIYY
                     VEV"
     gene            8813..9196
                     /locus_tag="KR257_002868"
     CDS             8813..9196
                     /locus_tag="KR257_002868"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428668.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0031548.1"
                     /translation="MSTDKVVGIIDEETAELAGIEYTGKIYASSGVIKHIKKKHRCQL
                     SKDIFNDIIDTIKMVLKSPEYIGSHPKKPGKSVEFIKKIDDYILVATELDTKKGYLYV
                     SSMYAIKEAKLESRVNSGRVKQYDG"
     gene            9704..10087
                     /locus_tag="KR257_002869"
     CDS             9704..10087
                     /locus_tag="KR257_002869"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428669.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YtxH domain-containing protein"
                     /protein_id="HBH0031549.1"
                     /translation="MNLSKKIEDKRKAKQRAEKVKKAKIATAGVVLGAVTGAVSGVLL
                     APKSGKETREDIKDASQQIAEKINMKTVDVKGKVSEKLEDKKGNFIESKKKIKKYIDN
                     KKSVENSSEEDKIIDIVEPVSVTEE"
     gene            10089..10439
                     /locus_tag="KR257_002870"
     CDS             10089..10439
                     /locus_tag="KR257_002870"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428670.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0031550.1"
                     /translation="MDNTITINISIIYVLLAILACIALVYLIIVLVKLHKILNNVGTM
                     LNENTQNINTTLNNLPNVVETFGEVGENMKDVTEVVTEVTADFLVTKDSVKSNMDVIV
                     DILTIIKNIFVDKK"
     gene            complement(10540..10998)
                     /locus_tag="KR257_002871"
     CDS             complement(10540..10998)
                     /locus_tag="KR257_002871"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435468.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0031551.1"
                     /translation="MIRTKVVELIATVCRENKPHKWVDENYTPYDKSGKVELMSIEDL
                     NELISSSGRADFLYSSRLQKLLNEVYINQSRASYISGCGLFWSSYWDILEEKFEEWLY
                     NSYIFFDEDDEYLEGMEDFELECKDVLMDVIETTSIDIYVQMIKRNITNY"
     gene            complement(11043..11831)
                     /locus_tag="KR257_002872"
     CDS             complement(11043..11831)
                     /locus_tag="KR257_002872"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729051.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="N-acetylmuramoyl-L-alanine amidase"
                     /protein_id="HBH0031552.1"
                     /translation="MKVVIIPGHTLIGKGTGAVGYINESKETRILNDLIVKWLKIGGA
                     TVYTGRVDESSNHLADQCAIANKQETDLAVQIHFNSNATTSTPVGTETIYKTNNGKTY
                     AERVNTRLATVFKDRGAKSDVRGLYWLNHTIAPAILIEVCFVDSKADTDYYVNNKDKV
                     AKLIAEGILNKSISNSQGGGENKVYENVIVYTGDADKVAAQILHWQLKDSLIIEASSY
                     KQGLGKKVYVVGGEANKLVKGDVVINGADRYETVKLALQEIDKL"
     gene            complement(11970..12407)
                     /locus_tag="KR257_002873"
     CDS             complement(11970..12407)
                     /locus_tag="KR257_002873"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897045.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cytidine/deoxycytidylate deaminase family
                     protein"
                     /protein_id="HBH0031553.1"
                     /translation="MNKKLENRCSWQEYFMRLCETVAERGTCDRAYVGAIIVNSENRI
                     VSTGYNGSISGDKHCSEVGHEMRDGHCIRTIHAEQNALYYCAKEGISVKNCSIYVTHF
                     PCLNCTKAIIQAGIKHIYYRTGYRIDEYAIKLLQSSNVLYTKL"
     gene            13229..13738
                     /locus_tag="KR257_002874"
     CDS             13229..13738
                     /locus_tag="KR257_002874"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009905613.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="HBH0031554.1"
                     /translation="MLSENIKTIRKSKGLSQQELAIKLNVVRQTISKWEQGLSVPDSD
                     MLISISEVLETPVSTLLGETIVESEVDNLKVISEKLEIINLQLAQRKNMRRKMFHWLF
                     ILLCAVILIVFVVLGRLNSPYLDWNYTDPETAVFGVAFHAFEWLFVRLVPIVLIGAII
                     GIFLTRKKI"
     gene            14152..14583
                     /locus_tag="KR257_002875"
                     /pseudo
     CDS             14152..14583
                     /locus_tag="KR257_002875"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016295744.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="MFS transporter"
     gene            complement(14770..14963)
                     /locus_tag="KR257_002876"
                     /pseudo
     CDS             complement(14770..14963)
                     /locus_tag="KR257_002876"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001227347.1"
                     /note="frameshifted; incomplete; partial in the middle of
                     a contig; missing N-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="XRE family transcriptional regulator"
     gene            15065..15571
                     /locus_tag="KR257_002877"
     CDS             15065..15571
                     /locus_tag="KR257_002877"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436824.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="VanZ family protein"
                     /protein_id="HBH0031555.1"
                     /translation="MKNEKKITVALLIVYLLILSWIILFKLQFSFSALDHIRQINLIP
                     FGGSVIANGKIDFDEIINNAIVFIPVGAYFSLLFKNKSVLKAIGSVLGISFVYEIIQF
                     IFAIGASDITDLISNTLGGIIGIALVYVLSIVLKDKTHKILNRIAIVCTVLVVAFLFM
                     LLAVNNIF"
     gene            15576..15852
                     /locus_tag="KR257_002878"
                     /pseudo
     CDS             15576..15852
                     /locus_tag="KR257_002878"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436830.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4865 family protein"
     gene            16121..16693
                     /locus_tag="KR257_002879"
                     /pseudo
     CDS             16121..16693
                     /locus_tag="KR257_002879"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902350.1"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="conjugal transfer protein"
     gene            16796..17611
                     /locus_tag="KR257_002880"
     CDS             16796..17611
                     /locus_tag="KR257_002880"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009901496.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="effector binding domain-containing protein"
                     /protein_id="HBH0031556.1"
                     /translation="MFKIGEFSKLTQVSTRMLRYYDETGLLKPAKIDSLTGYRMYSAE
                     QISTLNRIIYLRDSGFNVAEIALALNFSNNAIIEQLDRKSIEIMDNIQKEQEKLKKIE
                     IAKKEVLHGKSELYFNITIKEIPSYCVLSLRKEIPNYYYEGELWKELSAFAKENKINI
                     SDETFSIYHNEEYKEKDVDVELCAIVNKIGKATGDFKFRFTEPVSMMACTMVYGDFSN
                     ISYAYRSFAKWLQENSQYKMKGSSRQIVHRGPWNEKNPENYLTEIQIPLENLL"
     gene            17692..18168
                     /locus_tag="KR257_002881"
     CDS             17692..18168
                     /locus_tag="KR257_002881"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002608187.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SAM-dependent methyltransferase"
                     /protein_id="HBH0031557.1"
                     /translation="MTTYKVNSIGTICNNEKGAFIQLEAPYILALRALDGFSHINVLW
                     WFSDFDNTNFRSVLETEQPYKNAPEKMGIFATRSPVRPNPIALSAVEIIDIDYMSGLI
                     QIAYIDANDKTPILDIKPYTPSLDRVENPQVPDWCSHWPHSLEESASFAWESEFNF"
     gene            18182..18745
                     /locus_tag="KR257_002882"
     CDS             18182..18745
                     /locus_tag="KR257_002882"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437411.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HBH0031558.1"
                     /translation="MSLQDYIFEKPVIETEHLILRTMNKNDIDDLKEWISDISLYEYW
                     GKRPSKSEKNPELLFDKSKKSTKSFHWGIVHKQDSKVIGEIWIYLIENNRMAKVAFRL
                     SKHYQGNGLMSEVLKNVIEFCFSKTELQKIWTDVHILNHASYKTLEKVGFQREGHIRG
                     GKMVNTYCDYYLYGILKSDYITRWCYG"
     gene            19000..19911
                     /locus_tag="KR257_002883"
     CDS             19000..19911
                     /locus_tag="KR257_002883"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437415.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AraC family transcriptional regulator"
                     /protein_id="HBH0031559.1"
                     /translation="MYAYENIEMSLNYIEQHLSEKIETEKLAEIACLSTFYYQRLFKR
                     LVKKSVQEYIKLRRLAMVIAELNNSEERILDIALKYGFSDHANFTRAFKEVYHITPDE
                     YRKNVPMLNTFDKPELSSRYIMIDENVPLIVGNIVLEIQRKTLRTKETYFGFEKTVNI
                     SEQIPAGESTGIDVPGQLWREFHAKKLQTENAIFNNDIELGVSHLASPDKGTFLYFAG
                     GMVSSTDVCPKNMVQHTLPAGEYIVCKIEAESFEELVTTALNQANKYLFETWLPNHNL
                     VTKPFMAEKYYKGNAEINYMEIWIIPV"
     gene            19989..20423
                     /locus_tag="KR257_002884"
     CDS             19989..20423
                     /locus_tag="KR257_002884"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437417.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3788 domain-containing protein"
                     /protein_id="HBH0031560.1"
                     /translation="MINIKDINYVPNISEISVYIENSAFDELYQHMNNEYKAVCKIEY
                     SKDVWARGWNVKFKKSGKSLCVVYPKKNYFTVLVVVGNKEKEDVENLLPRLSEYVQEI
                     YRNTREGNGQRWLMIDLKSKNNVYQDVLRLIEIRYAIKCVKP"
     gene            20891..21540
                     /locus_tag="KR257_002885"
                     /pseudo
     CDS             20891..21540
                     /locus_tag="KR257_002885"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009243519.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus and C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="C40 family peptidase"
BASE COUNT         7891 a         3030 c         3508 g         7111 t
ORIGIN      
        1 ttaagcttga tttgattgga aaggtacaaa ctatcaccga aaaaaattaa acccatttaa
       61 aaagcaatat aaaagcttgt tatttttgag aaaaatagac cctctaaact caattagatt
      121 aaaaataaaa tacagaaaat tatatctcta aatatcttaa ataattaagt ttaaatttta
      181 cgatattttg tttgattatt tataatataa aagcatactc ttaatcttca aaatttaaaa
      241 agagtaaaaa ataacaaaaa aatcactgac atttcactga caaattgtaa ttttgttatt
      301 ataaatacat tgaaaatact tgattattga aaaatggcat aaaataatac attttatgcc
      361 atttactatt atttgatagt ttttaactta tgacataaga tattttttaa cacatacaat
      421 aaaatataaa aaaattgata ttgcaaataa aaaaaataca tattagatgt tatagaaaaa
      481 aagcgcactt ataggcttaa aatgtcacat aaaagagttt taaagaataa tatattatga
      541 acacaaattt tgtaatcaca aaggagtgat aatatggcaa cagtatcagg acaaatagtt
      601 tttgatagaa atagaagtgc taccattgat tctggagact caggaatagc caatatacca
      661 gttgtattac aagatatagc aactggagtt agacttgtgg ttctcacaga tgcatcagga
      721 aattatgttt ttactaatgt tccaaatggt aactatagaa ttgtagaagc ttttggaact
      781 acaggaggag taccaacacc agggaatttt gcaacagcga tagtaggtcc agttccaatt
      841 gcagaaatgc cacctattag tcctcctatt ggttcaacaa acttagatgg tacaacacct
      901 aacacactat taataacagt agcaggttca gatataacaa atcaaaatat attaaatggg
      961 cctgtgattt atacacctat agagaatata ttggattctt gcgtatctgt atctaatata
     1021 aaccttatta cagatgcaga taacggaaca ttcggttttt ttccaccagg tacaccaagt
     1081 aatacaggac ctgaaataga accttaccca aatgtgacgc cagattttac gtatgttgta
     1141 ccagacccaa ctaagtttac acctttagat ggagaatata cagtacaaaa tattatgaca
     1201 aatgcaatga gtaatgttat aggagcttgg tggcgtattg ctgaccatac tacaggaaat
     1261 gaaacaggaa gaatgatggt ggtaaatggt tttaatcctg gagctgtatt ttttaaatca
     1321 acagtacaag ttacacctaa cactaattat ttatttagca cttggatttt aaaccttttt
     1381 aaggtaacag gatatccacc accacagcta ggtgtaagaa tatttgacca aaataataat
     1441 atactatatc aagcaacatt aggagctcaa attccagtta atacaaacgc accagaatgg
     1501 aaagaagtag gtactgtgat taattctcaa aataataatc aacttacagt agaatttttt
     1561 agtgaaggag aaagcgccat tggaaatgat tatgctatag atgatgtttc tttaagagaa
     1621 atagctgttc caacttttac tccaataaaa acaagtaaca cagaaactgc taatgtaggt
     1681 gatataatca catatacagt tacattagat aatacttgtg atagcccttt aactaatgta
     1741 ttttttaggg atttaattcc aaatggttta gagtttatac ctggaactgt aacggttgat
     1801 ggagtatctg taccaggagt agaccctaat acaggtttct cacttccaga tattggagga
     1861 ggaacagggg ttgaagtaac ttttgatgtt gtggttgaaa gtattcctaa cccaaatcct
     1921 actaataata tagctaatat agattactcc tatacacctg tagaaggcgg tataccaaat
     1981 gatttttcag tagattctaa tccagttcct gttgaagtaa tatcagcaga tattgaagtt
     2041 acaaaattat ctgaacctac tatagtgaat ccaggagagg aattaatata cactataaaa
     2101 gtagtaaata atggaccatt cccatctgaa aatgtggttt taacagatga tgtaccagct
     2161 tctattataa atccagagta ttcattagat ggaggagtaa cttttcaacc atggactgga
     2221 agtttaaata tagggacatt agaagtagga gagacaagag ttattataat taggggtatt
     2281 gtaaatccat caacagtagg aattataaca aatacagctg tagtatcttc aactacagca
     2341 gacccaaacc ttaataataa tacatctaca atagagacag aagtgaattt attagcagat
     2401 attttagtaa tgaaaacagc agaacctaat tcagctgttc caggtacttt attgagatat
     2461 actattcaag tagaaaactt aggaccagca aatgctgaaa atgtaatatt aaatgatgat
     2521 attccagctt ctattataaa tccagaatat tcattggatg gaggagcaag ttttcaacca
     2581 tggaatggaa gtcttaatat aggaacttta aactctggaa tttcattaac agttttaatt
     2641 caaggaacag ttagtttaaa ttcttcagaa tatatagtaa atacagcaac agtttcttca
     2701 actacacctg acccagattt aagcaacaat atatctacca ttattacacc agttaaccca
     2761 caagcaggta tttctattat aaaagtagct gacgaggatg tagctgttcc aggagaagaa
     2821 tttgtatata caattgaaat ttttaatgaa ggaccatcta atgctacgaa tgtagtttta
     2881 acagatgata taccagatgt tattttaaat ccagaatatt cattggatgg aggagcaact
     2941 ttccaaccat ggaatggaag tcttaatata ggtacagttg caccagggca attaataaga
     3001 attatcataa agggattagt aagttcaact gctacaggag atattactaa tacagcagaa
     3061 gtaagtgcag atgtaccaga accagttacg gattcatcaa cagtgacaac tcctatagtt
     3121 ccatcagcag atatagaagt aataaaaact agcaatatgg atacagcagt tccagaagaa
     3181 actttcagtt atactataac agttacaaat ttaggaccat ctgctgcaca aagtatcgtt
     3241 ttgacagatg atataccaga tgttatttta aatccagagt attcattgga tggaggagta
     3301 actttccaac catggaatgg aaatcttagt ataggcactt tggatgctgg agaaataaga
     3361 agtattataa taagaggaac agtgagccag acagcagtag gtacaattat aaatacagca
     3421 acaataagtt cacctacacc tgacccaaat ccagataata atacttcaac agatgaaaca
     3481 gatataagtc cattagcaga tatttctgtg ataaaaggca acgaaccagt tgctatacca
     3541 ggaggaagat ttatttatgg aattgaaatt gcaaatgcag gaccatcttt tgcagagaac
     3601 gtaactttaa cagataatat accagcttct attttaaatc cagagtactc aatagataat
     3661 ggagtgactt tccaaccatg gaatggaagc cttaatatag gtactttaga tgctggagag
     3721 ataagaaata tcataataag gggaacagta agtcaaacag caataggtac aattataaat
     3781 acagcaacag taagttcaac tacacctgac ccaaatctaa ataacaatac ttcaacatca
     3841 gaagcagagg taagttcatc agcagatatt tctgtagtaa aacgaagcaa tcagactgtt
     3901 gttgtaccag gagatgtact agactataca attgaggtga gaaatgcagg accgtctact
     3961 gctcagaacg taactttaac agataatata ccagcttcta ttttaagtcc agaatattca
     4021 atagataatg gagtgacttt tcaaccatgg aatggaagtc ttagtatagg cactttagat
     4081 gctggagaga taagaaatat cataataagg ggaatagtaa gtcaaacagc aataggtaca
     4141 attataaata cagcaacagt aagttcaact acacctgacc caaatccaga taataatact
     4201 tcaacatcag aaatagatat aagttcatca gcagatattt ctgtaataaa attagcaaat
     4261 aaaacagaag catgtgtagg agagcaaata gattttgtaa tagtagtatc aaatgcagga
     4321 ccagaaaatg ctcaaaatgt tactttaata gacaatgttt cagataagct taagaaagca
     4381 gtattttcac ttgatagagg tgtaagtttc caaccatgga ctggaagtct taatataggt
     4441 acactaccag ctggaacttt aagagtgatt atattaagag gaattataaa atcaacatgt
     4501 cttgatagat taacaaatat tgcagaagtt acttcaacaa caccagattc aaaccttaac
     4561 aataatatat caagagtgca agtagaaata aaacaatttt gttgtaatga ttgtggttgt
     4621 aaagattgtt gctgtaattg ttgttgcaat gattgtggtt gtaaaaattg ttgctgtaat
     4681 tgttgtaaaa atgacttttg gtgttgattt tataaaataa ttttgtatac cttaaattaa
     4741 actgaaataa aaaataaatt cacatatgag taaaatattt tataaatatt aataaatttt
     4801 ctatctttga tatggaccac attcgtaata ctagttatta aatgaagtgg tcctttttaa
     4861 ttcattaaaa ttatttattc taattaaatt ttaaatgtat taaataattt taatttttta
     4921 taaaaaatat tcatatgtta tttatattaa agtttagata tctaaaaata cttttagaat
     4981 ttattatatt atgttaattt tttatatctt ataaggattg tatttttcta actataaaaa
     5041 tagtattata cttatattta aaaataaaag aattttattc ctattgtgta aagtgagaat
     5101 actattttct tatattggta taataatagt aaatctataa tatagaaaag aggtatttct
     5161 agtatgcatg aaaataaaaa aaatctatta gacggaagct tagctcaata taatgataca
     5221 gcagttccaa aaataccagt atttgctggt aacgatataa cttcagaagt ttattatttt
     5281 aaacctaatc aagttcttaa tgctcataga caccctaatg gtgaacaaat atttgtgttc
     5341 ctaaaaggag aaggtaaaat gaaacttggt gagcatgaat gtgatgtaaa aaacggagat
     5401 actgtatttg taccaacagg agagtggcat gaaattacta atggaagcaa tgaagaaatg
     5461 gtagccgttc aaattacaaa aattaatgct ggagcagaat acagaggata gatatataag
     5521 tacagttagt actttaatat ctattttatt atataaactt taatctcaaa tataaaaaga
     5581 gtcttttaaa aggctctttt tatatttttg ttaattttca ttataaaaac aagaaaatat
     5641 ctagctaaaa ctaatatatt ttatttaata ttttttatag cattgtttgc aaactcagta
     5701 tttacgatat ctttataagg tgcttcctta tctagttctt tagcttcttt cataacagtc
     5761 atcaatttct tcaaaccttc ctcttttaat acaggatttt gagaccatgc atctattgat
     5821 ttatatctat ctacaactgt tgttaaatct tctaaagata tatcttcaaa gaaaggttgc
     5881 atagccttag ctacttcttt gctagatgct tgttgaatcc ataattgacc tttataaaca
     5941 gcatttgtaa atctttgaat taaatcttta ttgtttttca tgtatgatct cgtagtagag
     6001 tatgctgtaa aaggtatttc tccagaatct tttcctatag atgtaactat atatccacta
     6061 ccttcttttt ccattgctgt tgctgtaggt tcaaatgctg ttgtaaagtc accctctcca
     6121 cctgcaaaag ctccagccat tacaccaaat tgtacatcag ttcttacatt aacattgcct
     6181 gcttttagat tttctccaat agtaagacct ttttctttta gaacatattc aaaagtcatt
     6241 agtggaactc caccttttct accacctaat atttcggttc cttttaaatc attgtaagag
     6301 aaattaggca tttttttcct agcaactaga aaactaccat ctctttttgt caattgagca
     6361 aagttcactg cataatcgtt tttgttttga ttatatacat atatagatgc ttcaggaccc
     6421 attaaaccta cgtttgcttc acctgaaatc aaagctgcca tagttttatc tgcaccttgg
     6481 gtatttataa ggtcaatctt tataccttca tcttcaaaga atcctttcgt aatagcagca
     6541 tactgtggag cataaaaaac agagtgagta acttctgcta tagttacttt atccagattt
     6601 ttagacgaag aagattcatc ttttttgtca ttagagttaa aatcacatcc agttagacat
     6661 attgtactta caatgataga gcttgctatt gcgactattt ttttaaacat aataaatacc
     6721 tcccataaga catacgaata gtatatagta ttaaatattt attgtagttg ttacaaaaat
     6781 gtatctatac ttataatatt tctacaaaaa cttaataata attttcagtt ttatgtttag
     6841 ttttttcagt aatgtgtaat attggataaa ttatattgat tatttataaa ctaagtaata
     6901 aaattaaaat aatatcactt ttttgtctat tatatataag gaaaaatttt ttaataatat
     6961 aaatcatatt catttatatt attaaaaaat ttgtttatag aaacttttat tattttatat
     7021 aaaagtgata aaaacttata ttttgtattt aatagagtgt tgctaagtga atatatttaa
     7081 aatggaggaa actttatgaa acaaaataaa tatgatgatg atagattttt taataaatac
     7141 agtaaaatgg aacgttctac aaatggatta gcaggtgctg gagagtggca tgttttaaaa
     7201 aaaatgttac ctgatttcaa aggaaaaaga gttttagatt taggatgtgg atttggatgg
     7261 cattgtcaat atgcagttga gaatggagca atttctgctg ttggagttga tatttcagaa
     7321 aaaatgttaa aagaagctag aaacaaaacg caacttgata atataaatta catatgtatg
     7381 cctattgaag atattaattt tccaaaagat agttttgatg tagttattag ttccttggca
     7441 tttcattata ttcaatcatt tgaagatata tgtaagaata taagtaattg tctttcaaat
     7501 aaaggtaatt ttgtattttc tgttgaacat cctatattta ctgcatatgg aagtcaagag
     7561 tggtactgtg ataaagatgg aaataatcta cactggccag tagatagata ttttgaagaa
     7621 ggagtacgta ggtcaaattt tctaggagaa gaggttataa aatatcataa aacattaaca
     7681 acttatttaa atgcgttaat gaaaacagga tttgaaatat tagaaattat tgaacctcaa
     7741 ccagaagaaa aactgttaga tacaattcct gatatgaaag atgagctacg tagacctatg
     7801 atgttacttg tatctgcaaa aaaaagataa gtaaatataa ataatcatta ttgtagaaaa
     7861 aaagttgtag aaaataatta cactaatgga gatgattata ccagtggtat taattacacc
     7921 agtagtaagg aggcaaaagc attcgttgct tttgccattt tttaagttgc aattatactt
     7981 ctacgtagta tatttcgttt ccattttctt ctataagctt tttcatatct tcaaatttta
     8041 aaaatacagt agcagtatta tcatttggat gtatacctat tttatccatt tttaataaat
     8101 ccttatcaaa tacaactttt acaacagcct ctttatcatt taatatacca aaaggagtca
     8161 cagctccttt agtaagtttc aagtattttt gaagtctttc ttctgatgca aaactaagag
     8221 gtttactatc aatttgttga cgaatatctt ttaaatctgc ttttttgtct ttacctaata
     8281 caactaaaaa atgttctttt cctttagcat cacgaagaaa taggtttttt acaacaaatt
     8341 ccatatgtaa tgtttttaat tcttccattt cttcaattgt ataaactggt ggatgattta
     8401 cagcctcata aggtatgctt aactcatcta attttttata tacttcctgt tgttgattgt
     8461 tcatgatttc ctcccattag aaatttattt tatatataaa taatattatc acagaaaact
     8521 ttaaaagaaa acgttttata taatatagac aatagattat atttttataa agaagcaaga
     8581 atactcaata aaacttaaag aaattaaacg atttctaaaa ataccttgaa aatagaacct
     8641 tatttgccat ttataaatta tataaaaagg gattatataa agtcatatat gaaaaaacta
     8701 tattatacta tcttttcttt ttggaataaa ctatacttta aatatagata tttaatttaa
     8761 ataaatttta cagtattaat agtaaattat cttagaaagg aatgtgcttt atatgtctac
     8821 agacaaagtt gttggaatca tagatgaaga aacggcagaa cttgcaggaa ttgaatatac
     8881 tggtaaaatt tatgcttctt ctggtgttat aaaacatata aagaaaaaac atagatgtca
     8941 actgagtaag gatattttta atgatataat agacactata aaaatggtat taaagtcacc
     9001 tgaatatata ggaagtcatc ctaaaaaacc tggaaaaagt gtggagttta taaaaaaaat
     9061 tgatgattat attttagtag ctacagaatt agatacaaaa aaaggatatt tatatgtatc
     9121 ttcaatgtat gctataaaag aagcaaaatt agaaagtaga gtaaacagtg gaagagtaaa
     9181 acaatatgat ggttaacata atattattaa ttttccctaa aatattgaaa aatattatta
     9241 tataagttat aatattaata tacacgtaga tatttattag ttagatttga ggttggaaaa
     9301 ggcacccaat acgctactat agagtagtta atagagatgc aggatacgcc gccctgccaa
     9361 atctaattaa attaaaaaga gaggattaat tcctctctta ttgttttttt gagatactaa
     9421 tttaatctat aatagaaaga ttgaaggtcg tttatacaaa aaaattttca gttatataca
     9481 ttaaactaat taaataagat atttataatc tatatgtgat acatattata tattaataaa
     9541 agaaaaatat atagaaaatc cttataaaaa tttaaattgt aatgaatagg aagtaattaa
     9601 aaagaatttt tattgatttt taaaaattta gttagaaact atatcattat ggtaaaaaat
     9661 gtattataat gtttagaaat attataataa ggagcgatta aacatgaatc tatcgaagaa
     9721 aatagaagat aaaagaaaag ctaaacagag agctgaaaaa gttaagaaag ctaaaattgc
     9781 tacagctggt gtggtattag gagctgttac tggtgcagtg agtggagtac ttttggctcc
     9841 taaatctgga aaagaaacaa gagaggatat aaaagatgct tcacaacaaa ttgctgaaaa
     9901 gataaatatg aaaactgtag atgtaaaagg caaagtatct gagaagctag aggataaaaa
     9961 aggaaacttt atagaatcaa agaaaaaaat aaaaaaatat atagataaca aaaagagtgt
    10021 tgaaaattct agtgaggaag ataaaataat agatatagtt gaaccagtta gtgttactga
    10081 ggaataatat ggacaataca ataacgatta acataagtat aatatatgta ttattagcta
    10141 tacttgcttg tattgcttta gtttatttaa ttattgtact tgttaaacta cataagattt
    10201 taaataatgt tggaactatg ttaaatgaaa atactcaaaa tataaataca actttaaata
    10261 atcttcctaa tgttgtagaa acttttggag aagtaggaga aaatatgaaa gatgtaacag
    10321 aagtagttac tgaagttaca gcagattttc ttgttactaa agacagtgtc aaatcaaata
    10381 tggatgttat agttgatata ttgactataa ttaaaaacat ttttgtagat aaaaaataat
    10441 aagttaatat aaaataagcc tataagatat aatttaaacg accttaaaat agcatttata
    10501 aggtcgtttt ttattagctt gatttgacac tatgtgtttt taataattgg taatattcct
    10561 ctttatcatt tgaacatata tatctatgct tgttgtttca attacatcca taagaacatc
    10621 tttacattca agctcaaaat cttccattcc ttctaaatat tcatcatctt catcaaaaaa
    10681 gatataagaa ttatatagcc attcttcaaa tttttcttca agtatatccc aatacgaact
    10741 ccaaaataat ccacaacctg atatataaga tgctctactt tgatttatat aaacttcatt
    10801 tagaagcttt tgtaatctac tgctataaag aaaatctgct cttccactgc ttgatattaa
    10861 ttcatttaaa tcttctattg acattaattc aactttacca cttttatcat aaggagtata
    10921 attttcatca acccatttat gtggtttgtt ttctctgcat actgttgcta tcaactctac
    10981 aacttttgtt cttatcattt ttttatccta acttatttat tttttataaa ataatcatga
    11041 ttttataatt tatctatttc ttgtaatgct aatttaacag tttcatatct atcagcacca
    11101 tttattacta catcaccttt tacaagttta ttagcttctc cacctacaac ataaaccttt
    11161 ttacctaaac cttgcttata actagacgct tcaattatta aagaatcttt caattgccaa
    11221 tgtaaaatct gagcagccac tttatcagca tcacctgtat aaacgattac attttcatac
    11281 actttatttt cccctccccc ttgagaattt gatatagatt tgtttagtat accttctgct
    11341 atcaatttag caactttatc tttattatta acataataat ctgtatctgc tttactatct
    11401 acaaaacata cttctattaa tattgctggt gcaatagtat gattaagcca ataaagacct
    11461 ctaacatcag actttgcacc cctatctttg aatactgtag ctaacctagt attcactctt
    11521 tctgcatagg ttttgccatt attagtctta tatattgttt ctgtccctac tggagttgaa
    11581 gttgtagcat ttgaattaaa atgaatctga acagccaaat cagtttcctg tttatttgct
    11641 atagcacatt ggtctgctaa atgattactt gattcatcaa ctcttcctgt ataaacagta
    11701 gctccaccta ttttaagcca tttaacaatt aagtcattca gtattcttgt ttctttgctt
    11761 tcgtttatat acccaacagc tcctgtacct tttccaatta aagtgtgccc tggtattatt
    11821 actactttca aactaacatc tcctttacaa ttaaatttaa cttctattta atatatgcat
    11881 aacctagaat tttgtttctt tttatatctt atacttttat tataacccat tttgtaaaaa
    11941 tatagaatat taagtaaata atgttaaaat tataattttg tatataagac attacttgat
    12001 tgcaataatt ttatagcata ttcatctatt ctatatccag ttctataata tatatgttta
    12061 attccagctt gaattatagc cttagtacaa tttaagcatg gaaagtgagt tacataaata
    12121 gagcaatttt taactgaaat accttctttt gcacaataat aaagggcatt ttgttcagcg
    12181 tgaatggttc taatacaatg tccatctctc atttcatgac caacttcact acaatgctta
    12241 tctccagaaa tactaccatt atatccagta gacactattc tgttttctga attgacaatt
    12301 atagctccta cataagctct atcacaagtt cctctttcag ctactgtttc gcacagtctc
    12361 ataaaatatt cttgccatga gcatctattt tcaagttttt tattcaaatc atatacctcc
    12421 aaaatttata tctaatatat aagatttata ccttaaaaat aatattaaaa acaaatttat
    12481 atgataaata aaatttatta atactgtttt tagtctaaat tatttcattt taaattaaag
    12541 ttacaaggaa tctaagatta tatatatctt tcttcgtaat atgaatgtta caatataaaa
    12601 aactgtctca ataaaataga gacagtttta cagtcaaagt ttataataca agttcatatt
    12661 tttctttaaa ttcttttaca gcttcgggcc atgccttttg ttctgtaata cctttttctt
    12721 tagctatttt aattgcaatc tctcttatca ttgcagcgcc ttctaatatt cccattttta
    12781 atctcccttc aaatatcttt ttgtatagaa tataaatagt gctaagattt attacatgct
    12841 gcatatacaa tatctataca acacataact tgtaaattcc ttttattttc atacgtcttt
    12901 aaccgacata taattatatt caataagttt taaaattatg aactcaatta taattatttt
    12961 tattttttta gaatctaaac actaaaaatt gtaggtaaat ttgtcttatg cctttataaa
    13021 tatttctaca gttttaatta ctggacatat ctatttttat tataaaaagc gattaaaaat
    13081 ggagaatatc ctcataaaaa ctatatataa gcaaaacggt taaaggaaaa agaagaaatt
    13141 tacttgaatg ttaaaatgcg ttgcttgaag caatgggcag ttttgcctat aatatcggta
    13201 acaactgaaa gaaaggtggt tagccctaat gttaagcgaa aacattaaaa caatcaggaa
    13261 gtcaaaagga ctttcacaac aagaacttgc tataaaactg aatgtagtgc gacaaacaat
    13321 atctaaatgg gaacaaggac tgtcggttcc cgattctgat atgttgattt ccatatcaga
    13381 ggtgcttgaa acgcccgtaa gcactttact tggagaaact attgttgagt cggaagttga
    13441 taacttaaaa gtgatttctg aaaaattaga gattataaac ttgcaacttg cacaaagaaa
    13501 aaacatgaga agaaaaatgt ttcattggtt atttatttta ttatgtgcag tcatattaat
    13561 agtttttgtg gtcttaggga gactaaatag tccttacttg gattggaatt ataccgaccc
    13621 tgaaaccgct gtttttggag tagcttttca tgcttttgag tggctatttg tcagattagt
    13681 accgattgtc cttataggag caattattgg aatctttttg acacgtaaga aaatatgaag
    13741 taactctgct ttttataata cagcaagcgt tccttaaaag cgtcattcta catggcaatc
    13801 gaggacgact atgtaaggaa gaaccttttt gatttccaac taagcgaagt tattgaggac
    13861 gacagtaggc ccaaaaccgc attaagtaaa gtacaggaag caagactgct ggacttatac
    13921 tctcatgcgt cagatgcagg aaatgcgagg tctggtagca tgatttacaa cgatttgtac
    13981 aacgactacg agtagaaata tatggagata agtattatct acgaaatcag aaaagaaatg
    14041 acttgataat ttactcatgt tataattatt gatgtgaaat taataaatcg aaattccttt
    14101 tttggattta acaatactga gtaaggaaaa agtgaattac ttttgcaagg aggtgttatt
    14161 tggatggtgc tagcaggtat tttgattgta gtacaaggct ttttgactgg tcctttagca
    14221 aaaaaaattg gtgagaagcg actaatactg ataggtatgt tttgcaaagc cttagtagcg
    14281 tttgccatgg tattgacaac tgggtttgtt agtgtgttgg tggtttttgg cttatttgcg
    14341 gtatcttctg ctattacagt acccacatta aacgcaaccc tttcaaaaac tgacaatcag
    14401 cataaaggaa cactgatggg atttgccagt accgccggaa atcttagcaa agttattgct
    14461 cctttattaa ctgggtatct gtatgaaagc aatattgaat taccatatat aaccacggga
    14521 gggatagcct taatcggagt ggttatctgc tatatctgga taaaaaatca aaagaacaaa
    14581 tgatggaaga ggacgtttat atggaggtta tacacagtaa ctaatctggt atagaaattc
    14641 aattgaggct tttctgcttt attaaagtct tgctactact taaccctata atatccttaa
    14701 ttcattatga caaattccaa ttcaacagtt ttgatacaca taaggaggta acaatactat
    14761 ggaaaattat caatgaagtg ctaattcttt atcagtgaag ttatccataa gtttttctac
    14821 ctgtaatcgt ctggtgcttt ttgccagatc attggtaggt aagaaaaatt catcaacaga
    14881 cacatgaagt aatgatacaa ggtcacttgt atgcttggat gttgcccttt attttcaata
    14941 ttagttaagt aacgtgggtc aatatttgta attcgatttt agggaaatat ttaaagaaat
    15001 attttcgttt tatttcttta aatcttcaag aatattgata gttttttgaa agtaggtgtg
    15061 tattatgaag aatgagaaaa aaattacagt cgcattgctc attgtttatt tattgatttt
    15121 atcatggatt attttattta agctacaatt ttcattttct gcgttagacc acataagaca
    15181 aataaactta attccttttg gtggttcagt tattgcaaat ggaaaaattg acttcgatga
    15241 aattataaac aatgccattg tttttatccc tgtaggtgca tatttcagtt tgctttttaa
    15301 aaataaatct gttctaaaag caataggttc tgttttagga attagctttg tatatgagat
    15361 aattcaattt atatttgcta tcggagcaag tgatattaca gacttaatta gcaacacatt
    15421 agggggtata attggaattg cattagtata tgtattatct attgttctaa aggataaaac
    15481 acataagata ttaaatcgaa tagcaatagt atgtactgta ttagtagttg ccttcttatt
    15541 tatgcttctt gctgtaaata atatatttta atgccatgtt aattacatgt tgttttggaa
    15601 aagactttaa tctgtcaaag tttgcttttg aaattgaaca tgaaattaca ccaatggaac
    15661 aaatgaaagc tataaatttt tcattggaga aagatgactg tacaagtaaa gtattaatat
    15721 acaatccaga caaatggaaa tatgtagaat actatttcta taaagataga cctattaaaa
    15781 aaactattgg aaaaatttat tcaattttgc atttgtcaca ataaaatatg ttttgaaata
    15841 ttgaatactt aaatatgcaa aaaaacaaat gtaactggct atggggctat atctactaaa
    15901 aagctatgtg ataggttggg attaaattta aacatcactt ctagaaggca tgaatacaca
    15961 aggctgacaa actatacagt tatgattaaa cgataccaac gggattgaaa atttcgtgaa
    16021 gaactttgag aagtcctatt acacatgagc aacagcaacg aagctattga agcaaggacg
    16081 caggcaatct agcggttatc tgacaaagga gttgtaggac ttgaatgtag atactatcag
    16141 aacggatata ccgaccagct ctgcggttac agatgtgatt gtgtagaata tcgagcagtc
    16201 gggaacggac actttatctg ctacctacga agtagatcag cagataaaag agagagaaca
    16261 gacaacagcg gtcaaggcaa cctataccgt aaaagtccat gtggacgctg acggggatat
    16321 ggtaatcgtt cagaacctta ctcttgcacc agcaatcgaa aaatcagact atgagccaaa
    16381 gatatcagaa acagacgcaa gcgtggacgc tgataccgtt aatgacgcta ccgcatttct
    16441 ggaaacattc tttgaggtgt acccgacagc cacagaaaaa gaacttgcct attatgtatc
    16501 ggaaaatgtg attgaaccta tcggcaggga ctacctttat tctgaattgg taaacccagt
    16561 ctttacaaag gacggggaca atgtgaaagt caaggtagct gtgaaattcc ttgataatca
    16621 gacaaaggca acgcaggtgt cgcagtatga tcttgtactc caaaaggata gcaactggaa
    16681 gattttagga taacatggaa atgggcttgt atcataatta tagtgtgcaa gcccttttca
    16741 tattgaagta tcaataatca ataattataa ttaggtacat gaatggaggg ataaaatgtt
    16801 caaaattggt gagttttcaa aattgacaca agtttctact cgtatgttgc gttattatga
    16861 tgaaacgggt ttattaaaac ctgctaaaat tgattcatta actggatatc gtatgtattc
    16921 agcagaacaa atctcaactt taaatagaat tatatattta cgtgatagtg gcttcaatgt
    16981 cgctgaaatt gcattagccc tcaatttcag taataatgcc attatagaac agcttgatag
    17041 aaagtctatt gaaattatgg ataatataca aaaagaacaa gaaaaactaa agaaaattga
    17101 gattgctaaa aaagaagtgt tacatggcaa aagtgaattg tattttaaca taaccattaa
    17161 agagataccg agttattgcg ttttatcttt aagaaaagaa ataccaaatt attattatga
    17221 gggcgaactc tggaaagaac tctctgcttt tgctaaagaa aataaaataa atatttctga
    17281 tgaaacattc tcaatatatc acaatgaaga atataaagaa aaagatgttg atgtagaatt
    17341 atgtgccatt gtaaataaaa taggaaaagc tacaggagat tttaagtttc gttttaccga
    17401 accagtttct atgatggctt gtactatggt atatggagat ttttctaata tttcttatgc
    17461 ttatcgttca tttgcaaaat ggcttcaaga aaacagtcaa tataagatga aaggttcaag
    17521 ccgtcaaata gttcatcgtg gaccgtggaa cgagaaaaat ccagagaact atctaacaga
    17581 aatccaaatt cctttagaaa atctcttgta aaaaatgata atctgccttg actttaacat
    17641 ggtgttaagg tttatcgttt atttatcaag aagaaaacgg aggaaaatat aatgacaact
    17701 tataaagtaa attcaatagg tactatctgc aacaatgaaa aaggtgcttt cattcaacta
    17761 gaagcaccat atattctagc attaagggca ttagacggat tcagtcatat aaatgtttta
    17821 tggtggttca gtgattttga taatacgaat tttagaagtg tattggaaac agaacagcct
    17881 tataaaaatg ctccagagaa aatggggatt tttgcaacaa ggtcgccagt acgcccaaat
    17941 ccgattgctt tatcagcagt agaaattatc gatattgatt atatgagtgg gctgatacaa
    18001 attgcttata ttgacgctaa tgacaaaacg cctatcttgg atattaaacc atacacgccg
    18061 agtttggata gagtggaaaa tccgcaagtt ccagattggt gtagtcattg gcctcacagc
    18121 ttagaagaat ctgcttcttt tgcatgggaa agcgaattca atttttaagg agtgatgaac
    18181 catgagtttg caggactaca tttttgaaaa accagtaatt gaaacagaac atcttatttt
    18241 aagaacaatg aataaaaatg acatagatga tttgaaagaa tggattagtg atatttcttt
    18301 atacgagtat tgggggaaac gtccctcaaa aagcgaaaaa aatccagaat tactctttga
    18361 taagtcaaaa aaatctacta aaagttttca ttggggtatt gtccataaac aagatagcaa
    18421 agtgattggt gaaatatgga tatatcttat tgaaaataat agaatggcaa aagtggcttt
    18481 cagactttct aagcattatc aaggtaatgg actaatgagt gaagtgttga aaaacgtaat
    18541 tgaattttgt ttttcaaaaa cagaattaca aaaaatatgg acagatgtgc atattttaaa
    18601 tcatgcttct tacaagacat tggagaaagt cggttttcaa agggaaggac atattcgagg
    18661 ggggaaaatg gtaaatacct attgcgacta ctacctatat ggaattttaa aatctgatta
    18721 tatcactagg tggtgctatg gctaatattg aagcgacgat tggcgaagca atgaacaata
    18781 cagttccaaa ggtctatgat acgaaaagca ttaaaagata tgtgatgaat ttattagata
    18841 tggctcatta aaaagtacca aagaaataaa agttaccata tagacaaaat tggtttttta
    18901 tatcttttga tttcttataa gataatggca ttgtgcgaca agctatgcaa aaaattttca
    18961 tgtatacttt gattataatt tatacaagga ggtactgata tgtacgcata tgaaaatatt
    19021 gaaatgtcat taaactatat tgaacaacat ttaagtgaga aaatcgaaac agagaaactg
    19081 gcggaaattg cctgtctttc tacattttat taccaacgct tgtttaaaag gttagttaag
    19141 aaatcagttc aagagtatat caaacttcgc cgtttagcaa tggtaatagc agaattgaat
    19201 aattcagagg aaagaatatt agacatagct ttaaaatatg gattttcaga ccatgctaac
    19261 ttcacaagag catttaaaga agtttaccat attactcccg atgaatacag aaagaatgtt
    19321 cctatgttaa atacatttga caagccagaa ctttcttcac gttatatcat gattgatgaa
    19381 aatgtcccat tgattgtagg aaatattgtt ttggaaattc aaagaaaaac attaagaaca
    19441 aaggaaacat attttggttt tgaaaaaaca gtaaatattt ctgaacaaat tcctgctgga
    19501 gaaagtacag gaattgatgt tccaggtcag ctatggcgcg aattccatgc aaagaaactg
    19561 caaaccgaaa atgccatttt taacaatgat attgaacttg gtgtatctca cttagcaagt
    19621 ccagataaag gaacattcct ttactttgca ggaggtatgg tttcatcaac agatgtatgt
    19681 cctaaaaata tggtacaaca tacattacca gcaggtgagt atattgtatg caaaattgag
    19741 gcagaatctt ttgaagaact tgttactact gctttaaatc aagcaaataa gtatctgttt
    19801 gaaacttggc ttccaaatca taatttggtt acaaagccat tcatggcaga aaaatattac
    19861 aaaggaaatg cagagattaa ttatatggaa atatggataa ttcctgtgta aacagtaaat
    19921 gctaaatagg aattatctga cgtaataaaa aggaaataga aagcttataa aggagggcat
    19981 agtccgttgt gataaacata aaagatataa attatgtacc taatattagt gaaataagcg
    20041 tttatattga aaactctgca tttgatgagt tgtatcagca tatgaacaat gaatataaag
    20101 cagtttgcaa aatcgaatac agtaaagatg tctgggcacg aggttggaac gtaaagttta
    20161 aaaaatctgg gaaatcattg tgtgttgtct atccgaagaa gaactacttt actgtattgg
    20221 tggttgtagg taataaagag aaagaagatg ttgaaaactt gttacctagg ctttctgaat
    20281 atgtacagga aatttatcgt aacactagag agggaaatgg acaaaggtgg cttatgatag
    20341 acttaaaatc taaaaataat gtatatcaag atgtattaag gcttattgaa attcgttatg
    20401 ccataaaatg tgtaaaaccg taataaaaat atttttcaca tacgtaatct caaggtatta
    20461 tcgttgagac aagtaaccta tataattatg ggaaatgaga tttttagata cttaagaaag
    20521 tactttaggg ggcttgcgtt atggaaagat ttaagtacaa ttccacacaa tcaaatacaa
    20581 tctaataaaa ctttactaaa aattgaatgc aatacagctt taaaggctcg tacaaactat
    20641 atgttttgtg cgggcttttt tcatttaata ggaatttgga ttcgtcagag agtatattat
    20701 aaaaataaaa cgataagggt accttaaaaa taaggtacct caggctgtag acaaagtccc
    20761 ggactctcgt ctgggctttt cttatatttg agttatccac aattcaactt tttaagagtt
    20821 atcttattaa gaaaaaagtg tatgttttcc accctatagt tttacttctg tgatatttgc
    20881 agatgccact caagtagaaa gtggtggtac ggcagaagat gtcatgcaga gttcagaaag
    20941 tctgggacta ccgcctaatt ccttagacac ggaaagctca atcaagcagg ggtgtaagta
    21001 ttttgcgtcc ctgctttctt cctgcaaaaa tcaaggtatc gacgatttga atgtagcgat
    21061 acaatcttac aactatggcg ggggttatgt gggctatgtg gcaggaaaag ggaaaaagca
    21121 cacttttaat cttgcagaga gcttcgcccg tgagaaatcg ggtggaaaga aagtaaccta
    21181 cgccaacccg atagccgttg caaagaacgg gggctggcgg tatggctatg gaaatatgtt
    21241 ttatgtggaa ttagtcaatc agtatttaac tgttccgcag gtatcgggag agctggcaca
    21301 aaaggtaatg aatgaagcgt tgaagtatca agggtggaaa tatgtgtttg ggggaagcaa
    21361 tcccaacact tcctttgatt gtagcggact tgtgcaatgg tgctatggaa aagctggtat
    21421 ctacttaccg agaacggcac aaacacagta tgacgcaacc cagcatatcc ctttatcgca
    21481 ggcaaaagct ggggagttgt tctttttcca ttcaacctat aacgctggtt cgtatgtaac
//
LOCUS       DAEPID010000071        20621 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.071, whole genome shotgun sequence.
ACCESSION   DAEPID010000071 DAEPID010000000
VERSION     DAEPID010000071.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 20621)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 20621)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..20621
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.071"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            complement(<1..251)
                     /locus_tag="KR257_002886"
     CDS             complement(<1..251)
                     /locus_tag="KR257_002886"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420381.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0031561.1"
                     /translation="MKIHSIQNLTLDTRNLIKKYSLTLNEDLIWEFKHGKYHTIKYFT
                     HKFAVKESVLALLFNIHKLCYAKIKYFESSFSKYEPYKY"
     gene            complement(652..1113)
                     /locus_tag="KR257_002887"
     CDS             complement(652..1113)
                     /locus_tag="KR257_002887"
                     /EC_number="2.5.1.78"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454467.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="6,7-dimethyl-8-ribityllumazine synthase"
                     /protein_id="HBH0031562.1"
                     /translation="MIYEGKLIGKDLKIGIINSRFNEFITSKLLSGAEDCLLRHDVSP
                     ENIEIVWVPGAFEIPLVAQKMAKSGKYDAIICLGCVIRGATSHYDYVCSEVSKGIAKV
                     SLDSELPVIFGIVTTENIEQAIERAGTKAGNKGYDCAMNALEMANLFKSLD"
     gene            complement(1218..2411)
                     /locus_tag="KR257_002888"
     CDS             complement(1218..2411)
                     /locus_tag="KR257_002888"
                     /EC_number="3.5.4.25"
                     /EC_number="4.1.99.12"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889591.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional
                     3,4-dihydroxy-2-butanone-4-phosphate synthase/GTP
                     cyclohydrolase II"
                     /protein_id="HBH0031563.1"
                     /translation="MFNTIEEAIEDIKNGKMVIVVDDESRENEGDLLMAAEMATPESI
                     NFMATYGRGLICLPATEKKFKSLNIPLMVRENTDTFQTAFTVTIDGADTLTGISAYER
                     AETVKLFCDENSTSKDFKTPGHIFPLIAKTGGVLVRDGHTEASVDLARLAGFKEIGLI
                     CEIMKDDGTMARVDDLMIFKEKHNLKIITIKDLIEYRKINETTIEKVSSAFLPTKYGN
                     FEIIGYRDTYSNEEHIALTYGNINIENTLVRLHSECLTGDVFHSLKCDCGLQLESSMK
                     KIVENGSGVLIYMKQEGRGIGLLNKIKAYKLQEEGYDTVEANLMLGFEEDMRDFYMAA
                     QILKNLNIKSINLLSNNPDKINQLEKYGIKIENRIPINEEINDFNKLYLKTKKDKMGH
                     LLDII"
     gene            complement(2434..3099)
                     /locus_tag="KR257_002889"
     CDS             complement(2434..3099)
                     /locus_tag="KR257_002889"
                     /EC_number="2.5.1.9"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430166.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="riboflavin synthase"
                     /protein_id="HBH0031564.1"
                     /translation="MFTGIVEEVGILRKITANGKSGKVTILSNKILDGTNLGDSIAVN
                     GVCLTVSNLGKNEFTADVMMETIRSTNLGLLNANDKVNLERAMSLSSRFGGHIVTGHV
                     DGKGTICKFEKDENAVLVSIRPDKKLLSSMILKGSVAIDGVSLTISYLDDEIFKVSII
                     PHTKINTILLTKNVGDFVNLESDVIGKYVNNFMANNYKELNSNSSNHKSNIDKDFLFK
                     NGF"
     gene            complement(3133..4245)
                     /gene="ribD"
                     /locus_tag="KR257_002890"
     CDS             complement(3133..4245)
                     /gene="ribD"
                     /locus_tag="KR257_002890"
                     /EC_number="1.1.1.193"
                     /EC_number="3.5.4.26"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896839.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional
                     diaminohydroxyphosphoribosylaminopyrimidine
                     deaminase/5-amino-6-(5-phosphoribosylamino)uracil
                     reductase RibD"
                     /protein_id="HBH0031565.1"
                     /translation="MNFVNQKEKDIYYMKKAIELAKNGEGFVNPNPLVGCVIVKDSNI
                     IGKGYHEKFGSNHAEVNAINSAKQSLKDSTLYVNLEPCSHYGKTPPCVDKIIQNKIKR
                     VVISTLDPNPLVCGNGVKKLKDNNIDVTVGILEDEARDLNEAFFYHIKNKRPLCIVKS
                     AVSLDGKIATKSLESKWISNESSRYLTHKYRNKYQSIMVGINTVLNDNPLLTCRLNQE
                     KVSHPTRIVIDTHLKLPLNSNLVKDKTSKTIVFTCCKESIKLSMLKENNVETIISPSK
                     NNLVDLEFVMYKLGELNIDSVLVEGGATLNDSLFRNKLVDKVKLFLSPKIIGGKDAPT
                     FVSGEGINHLSDSTQLTINNVTLIDGDILIESDVLN"
     regulatory      complement(4377..4498)
                     /regulatory_class="riboswitch"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00050"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="FMN riboswitch; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /bound_moiety="flavin mononucleotide"
                     /db_xref="RFAM:RF00050"
     gene            4687..7169
                     /gene="recQ"
                     /locus_tag="KR257_002891"
                     /pseudo
     CDS             4687..7169
                     /gene="recQ"
                     /locus_tag="KR257_002891"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729557.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="DNA helicase RecQ"
     regulatory      7258..7369
                     /regulatory_class="riboswitch"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00059"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="TPP riboswitch; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /bound_moiety="thiamine pyrophosphate"
                     /db_xref="RFAM:RF00059"
     gene            7511..8812
                     /gene="thiC"
                     /locus_tag="KR257_002892"
     CDS             7511..8812
                     /gene="thiC"
                     /locus_tag="KR257_002892"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889633.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphomethylpyrimidine synthase ThiC"
                     /protein_id="HBH0031566.1"
                     /translation="MNYTTQMDAARKGIITKEMEIVSQKEQVDVNELRELIANGQVVI
                     PANKNHKSLSAEGVGKNLRTKINVNLGISRDCKDIEKELEKVRVAIDMKAEAIMDLSN
                     YGKTREFREKVVEMSPAMIGSVPMYDAVGYLEKELKDITEEEFLNVIRQHAIDGVDFI
                     TIHAGLTRSVCQKIKNHERLTHIVSRGGSLLFAWMELNNKENPIYTNFDKILDICEEY
                     DVTLSLGDACRPGCIKDSTDGVQIQELVVLGELTKRAWERNVQVMIEGPGHMAIDEIE
                     ANVVLEKRLCHGAPFYVLGPLVTDIAPGYDHITSAIGGALACAKGVDFLCYVTPAEHL
                     RLPNLDDMKEGIIAAKIAAHAGDIAKNVKGAREWDNKMSKARADLDWCEMFRLAIDPE
                     KAKRYRDESTPTHEDSCTMCGKMCSMRTVKKILNNEELNLI"
     gene            8866..9060
                     /gene="thiS"
                     /locus_tag="KR257_002893"
     CDS             8866..9060
                     /gene="thiS"
                     /locus_tag="KR257_002893"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430174.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sulfur carrier protein ThiS"
                     /protein_id="HBH0031567.1"
                     /translation="MKVNGKEIEFEKDLTVIDLLNKYNLKSDRVVVEVNLEIIEESNY
                     NTYVLKDEDIVELISFIGGG"
     gene            9053..9856
                     /gene="thiF"
                     /locus_tag="KR257_002894"
     CDS             9053..9856
                     /gene="thiF"
                     /locus_tag="KR257_002894"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420389.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="thiamine biosynthesis protein ThiF"
                     /protein_id="HBH0031568.1"
                     /translation="MVKIKIFVNELLTDVEENTTAYKVRDSYNNKCDVLVLNGYPIKT
                     DMTLCENDKLTLIQKGVKPSLDELESLLIARHTPNIHNKLKKGKVAILGLGGLGSNIA
                     ISLARIGVGELLLIDYDVVEPSNLNRQQYFIDDIGKLKTDAMIENIKKINPFIKLNKR
                     DIFLNKNNMDTIKDSDLIIEAFDDASCKAQVCNYVLINLKDKYLIASSGMAGYYDSNI
                     ITTKKIKDRFYICGDFVNEAKFGEGLMAPRVAICANHMANLATQILIDM"
     gene            9919..10689
                     /locus_tag="KR257_002895"
     CDS             9919..10689
                     /locus_tag="KR257_002895"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018592874.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="thiazole synthase"
                     /protein_id="HBH0031569.1"
                     /translation="MDKLVLGGHEFNSRLLVGTGKYGSNNILPEVIKESGSEIITMAL
                     RRVDLDNKQENILTYIPKEMTILPNTSGATNAEEAVRIARISRKMGCGDFIKIEVISD
                     TRYLLPDNEETIKATKILADEGFIVLPYMTPDLYAGRRLIEANAAAVMPLGAPIGSNR
                     GLQMKEMIRIMIDELDIPIIVDAGIGKPSQAMEAMEMGADAVLVNTAIASAGDPVQMA
                     RAFKLAVEGGREAYIAKTGNVSEFANASSPLTGFLGNL"
     gene            10706..11809
                     /gene="thiH"
                     /locus_tag="KR257_002896"
     CDS             10706..11809
                     /gene="thiH"
                     /locus_tag="KR257_002896"
                     /EC_number="4.1.99.19"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454452.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="2-iminoacetate synthase ThiH"
                     /protein_id="HBH0031570.1"
                     /translation="MSFYDVIEKYRDFDFDGYLNNVTDNDVLRSLSKDKLEDFDILNL
                     LSKTAVKHLEDMAQKAHKLSVQYFGKTVCLYTPMYIANYCVNQCVYCSYNIKSGIKRK
                     KLTMDEIREEGEAISKEGFKHLLVLTGESSFHSSVEYIGEAIEILREKFPSIGIEVYP
                     MEVEEYKYIVDKGVEGLTVYQETYDEEIYKRVHIKGPKSNYKFRLDAPERGAKAGMRT
                     LSIGALLGLNDFRKETFFTILHGKYLKTKYPHIELSYSTPRMRPFKGCFEELVDISDT
                     DLVQAMVCMRLFDPHAAINISTRENLEMRSHIIPLGVTKLSAGVSTDVGGHSQDEHDT
                     AQFKINDESTVKDVEKMLNSIGYQHVFKDWERF"
     gene            11810..12499
                     /locus_tag="KR257_002897"
     CDS             11810..12499
                     /locus_tag="KR257_002897"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889638.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="thiamine phosphate synthase"
                     /protein_id="HBH0031571.1"
                     /translation="MYLITNRKLCSEERYLEVIKESILSGVENIIIREKDLEYQELRK
                     LYMKIKTKINCIDFQEQISDESLKTNINQKECRNKFKVNFIINSNIEFFEKVDCQGIH
                     LPFKLFLNLIENKYNFNENKILGLSLHKVEEVDYLEKLIRNQNIKIDYITLSHIYETK
                     CKEGLNPKGIELLKEAKKITDIKIIALGGILPSNVKETLKYCDDFAIMSTIMRSKDIK
                     KTISNYNEKLN"
     gene            12687..14081
                     /gene="yfcC"
                     /locus_tag="KR257_002898"
     CDS             12687..14081
                     /gene="yfcC"
                     /locus_tag="KR257_002898"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422454.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="putative basic amino acid antiporter YfcC"
                     /protein_id="HBH0031572.1"
                     /translation="MTDSKKKRFIIPHTFTIIFLLIVLMAILTWIVPSGEFSREDVEG
                     RMVVVPGTYQSVESNPQGFADVFKAPIEGFIDSAEVVGFVLIVGGAFGIVNRTGAIEA
                     GIASVISKFKGKELLIIPISMILFGLGGTTFGMAEETLPFYMIFVPLMTSLGYDSLTA
                     IAIVFIGAAAGAAASTINPFSVGIAQALAQLAPGSGVTYRVVIFIAYILISIAFVMYY
                     AKKVKENPESSIVYEIDKNNKSILNQTSTEIKEFTFKEVSVLAIFGIGMAIMIWGVLS
                     QGWYIPEISMCFAAIGVLSGLVGRLSQIEISESFIDGAKDLASAALAIALARGIVIIA
                     QNGFIIDTILNSAAAFLGGLPKVIFVYLSFFLEAALAFLIPSSSGLASLTVPVLAPLG
                     DLVNISAQVIVTAYQFGVGLTNFITPTSGVLMGALAVAHIPFSKWVRFIMPILLILTA
                     VSLVFLTIGIYIGF"
     gene            14598..15965
                     /locus_tag="KR257_002899"
     CDS             14598..15965
                     /locus_tag="KR257_002899"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430181.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GTP pyrophosphokinase"
                     /protein_id="HBH0031573.1"
                     /translation="MGLKEFDFIEESIDMLRTMSPTLETISDEIEEYFENILDEKNQE
                     YINVTSRIKSESSLREKIIRNRYLKKYGEASNLIHNVSDLIGLRIECRFIEDENKIYR
                     LLRRYFNKTDDKINYYNKENKNIKLKLSERQPNKQKNGFEIYKIDGVFAYLDREVKFE
                     LQIKSLVNVFWSEIEHKIIYKNNTYLLADKFIKDMMDSIKNNLTMIDNQLLSIYKNFH
                     SGKSFNMKVSKKEIEKLFAKLVYDAFSEKMNKSIGFVVDFKKPCETILNYSFNKQDIS
                     DEVLGNFMLDEFARLNEIVNKDIDFNEQIEFEREPTFDDKFCKDLGNHFRSRLNTEFP
                     WNLFFRILFEIEPYNNTKDFENFVEFIKENVLLEENREQLLCQFEEDSKLIIEDIYDC
                     IFNSISEIDSVEILYNYNLEKINFTSSEIINCICREYECYGEYLEEKEKLMNTFKEKI
                     IQIFE"
     gene            15990..16598
                     /locus_tag="KR257_002900"
     CDS             15990..16598
                     /locus_tag="KR257_002900"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729555.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="molybdenum cofactor guanylyltransferase"
                     /protein_id="HBH0031574.1"
                     /translation="MRHFSNIYELSKIILEEAICIEKTGVILAGGRNSRMGRDKAFLE
                     LHDKLFIEIAIEAFKNFDELIIISNNEELYSKYDIKVYNDIVKDVGPIGGIYTALEYA
                     KYDIVTIACDMPYLNNQIVERIANKMNDKSVISVTNGKLQPLCSGYKKSIINKVSLCI
                     RENDLKLRSFIDKIDKSYIYFDEEDLFLNVNTVDEYEKLTKV"
     gene            16646..17017
                     /locus_tag="KR257_002901"
     CDS             16646..17017
                     /locus_tag="KR257_002901"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454444.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CoA-binding protein"
                     /protein_id="HBH0031575.1"
                     /translation="MNLLKCDSWAVILNNSDKESKAYKILDELKRNMYKVVAIDEEKK
                     PIEGIDVYECLKDVPHNIDVVAIIDKQSKMDVILEEVELLDIQNMWFEKGSFSEMMIK
                     KTKDLKLNIEYNLSLYDELTR"
     gene            17196..17534
                     /locus_tag="KR257_002902"
     CDS             17196..17534
                     /locus_tag="KR257_002902"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420397.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="heavy metal-binding domain-containing protein"
                     /protein_id="HBH0031576.1"
                     /translation="MLIVTTEKVEGKKISKVLGLVRGSTIRAKHVGKDIGASFKNLVG
                     GELTGYNEMLTEARQIAIGRMVEDAEAKGANAVIAFRLSSASVMQGAAEMLAYGTAVV
                     LEDDNSILEK"
     gene            18000..18503
                     /locus_tag="KR257_002903"
     CDS             18000..18503
                     /locus_tag="KR257_002903"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893248.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MogA/MoaB family molybdenum cofactor
                     biosynthesis protein"
                     /protein_id="HBH0031577.1"
                     /translation="MFNVAIITLSDKGYEGKREDITGKKLTEFVENTGAYKVTEYVLI
                     KDDKEMLKENIIRLCNSNKIDLILTNGGTGFSKRDITPEATKEVLEKEIPGLSEYMRM
                     KSTEITKKAILSRGVSGIRNNSIIINLPGSPKGAVENLSFIIDVLDHGIEVLRGEATE
                     CATKKSE"
     gene            18550..19509
                     /gene="moaA"
                     /locus_tag="KR257_002904"
     CDS             18550..19509
                     /gene="moaA"
                     /locus_tag="KR257_002904"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889647.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GTP 3',8-cyclase MoaA"
                     /protein_id="HBH0031578.1"
                     /translation="MIDKYGRKIDYLRISLTDKCNLRCVYCMPPDVKFDKNYINENLS
                     FEDYKFIIKAMAEQGITKIRFTGGEPLLYPKLNELIKFTKEECGINNIGMTTNAIGLS
                     DRIFELEKCGLNKVNISLDSLKEYKYKSVTRGGNLKDVLKSIESCLNLGIKVKLNCVA
                     ISGFNDDELKDFMFLTVKSPIDVRFIELMPLGEANRVYKKGYFNVKEMIEKIYGLYKV
                     KNDEKSTAEYYMFKGAKGRIGIITPLSCSFCNTCNRIRLTSSGAIKLCLHSKEEIDIK
                     PFLHKPLLFRESMKDIIKQKPEKHHLIENKCSDTNRRMYEIGG"
     gene            19513..19983
                     /gene="moaC"
                     /locus_tag="KR257_002905"
     CDS             19513..19983
                     /gene="moaC"
                     /locus_tag="KR257_002905"
                     /EC_number="4.6.1.17"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420402.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cyclic pyranopterin monophosphate synthase MoaC"
                     /protein_id="HBH0031579.1"
                     /translation="MLTHINEKGYAKMVDISEKDDTKRTAVATATITLSKEALEKVKN
                     GQIKKGDVLSVAQVAGIMGAKNTSSNIPMCHQIKLVGCDLEFDVDDSMSAIKIYATCK
                     SLGKTGVEMEALNACSLAALTIYDMCKAVDKKMVISNIHLVEKTGGKSGDFKFE"
     gene            20019..20450
                     /locus_tag="KR257_002906"
     CDS             20019..20450
                     /locus_tag="KR257_002906"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430188.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MOSC domain-containing protein"
                     /protein_id="HBH0031580.1"
                     /translation="MAKVVSINISEKKGVIKVPVQCAELKINHGIVGDAHAGNWHRQI
                     SLLGKESIDKMKMKGFDQLKYGDFAENVTTEGIEVFSLPVGTKLRIGQCEVEVTQIGK
                     KCHNGCEIKKLTGDCVMPREGIFVKVLKEGIINVNDSIDVI"
BASE COUNT         8022 a         2234 c         3494 g         6871 t
ORIGIN      
        1 ctatatttat aaggttcgta ttttgaaaaa ctcgactcaa aatattttat tttagcataa
       61 cataatttgt gtatgttgaa caaaagtgca agaacagact ccttaactgc aaacttatgt
      121 gtaaagtatt ttatcgtgtg gtatttacca tgtttaaact cccaaattaa atcctcattt
      181 aaagtaagag aatatttttt tataaggtta cgcgtatcta gtgttaaatt ttgtattgaa
      241 tgtattttca taatttattc tcctcataaa tatttaataa gtattaaatt atagtgtttt
      301 attattaatt gttcttaatt atattgtatg gtaaattaaa aaagtaataa aatagataat
      361 taatatacta gtaatatatg ctataaataa aaacaatagc taaaatagta atatatatgt
      421 ttttatgata ttttatgttt agggttatat ttgtaattat tttaagcttc taaaagtaga
      481 tttgatggat aacgtataat tttagaagga tatgcaattt gtttgataag aacgtacata
      541 tgattaaatt aaaaatatta agtaccaaaa agaagaaaga tagtttctcc ctttggtact
      601 taatattttg tatcctttac actaattttt aatatttatt aatgatatta tttaatctag
      661 agacttaaat aaatttgcca tttctagcgc attcatagca caatcataac ctttatttcc
      721 agcttttgta cctgctcttt caatagcttg ttcaatattt tctgtagtta cgattccaaa
      781 tataacaggt aattcactgt ctaaagatac tttggctatc cctttagaga cttcactaca
      841 tacataatca taatgagaag tagcccctct tataacacag cctaaacaga ttatagcatc
      901 atacttacca cttttagcca ttttttgagc aacaagagga atctcaaaag ctccaggtac
      961 ccaaactatt tctatatttt ctggagaaac gtcatgtctt aaaagacagt cttcagctcc
     1021 tgataaaagt tttgatgtta taaattcatt aaaacgagaa tttattatac ctatttttaa
     1081 atcttttcca ataagttttc cttcatatat catttttact tcctccaatt ttatttatgt
     1141 tatagattta tatttataaa tatctttaat ttaattataa aaaactactt agtagaaaaa
     1201 tatcatcata taatcattta tataatatct aaaagatgtc ccattttatc ttttttagtt
     1261 tttaaatata gcttattaaa gtcattaatt tcttcattaa tagggattct attttcgatt
     1321 tttattccat atttctctaa ttgatttatt ttatctgggt tattacttaa aagatttata
     1381 ctttttatgt ttaaattttt taatatttga gcagccatat agaaatctct catatcttct
     1441 tcaaatccaa gcattaaatt tgcttcaaca gtatcgtaac cttcttcttg aagtttataa
     1501 gccttaattt tatttaaaag accaatacct ctaccttctt gcttcatata aattaaaact
     1561 ccacttccat tttccacaat tttcttcata gaagattcta gctgtaatcc acaatcacat
     1621 tttagagagt ggaacacatc tcctgttaaa cattcagaat gaagtctaac tagagtattt
     1681 tctatattta tatttccata agtaagggca atgtgttctt catttgaata agtatctcta
     1741 tatcctatga tttcaaaatt tccatatttt gtcggaagga aagcactaga tactttttct
     1801 atagtagttt catttatttt gcggtattct ataaggtctt ttatagtgat gatttttaaa
     1861 ttatgctttt ctttgaaaat cattaaatca tcaactcttg ccattgtacc atcatctttc
     1921 attatttcac agataagacc aatctcttta aaacctgcaa gtctagcaag gtctactgag
     1981 gcttctgtat gtccatccct gacaagaact ccaccagttt ttgctattaa aggaaagatg
     2041 tgaccaggcg ttttgaaatc tttacttgta gaattttcat cacagaataa ttttacagtt
     2101 tcagctcttt catatgcaga tataccagtt agagtatctg ctccatctat agtaacagta
     2161 aaggctgttt gaaatgtatc tgtattttct ctaaccataa gaggtatatt aagactttta
     2221 aatttttttt cagtggcagg tagacaaatt agacctctac catatgtagc cataaaattt
     2281 attgattcag gagtagccat ttcagctgcc atcaataaat ctccttcatt ctctctactt
     2341 tcatcatcaa ctacgattac cattttccca ttttttatat cttcaatagc ttcttcaata
     2401 gtattaaaca tgtaattcac tcctttatta tttttaaaaa ccatttttaa ataaaaaatc
     2461 tttatctata tttgatttat ggttactact attagaattt aattccttgt agttattagc
     2521 cataaaatta ttaacatact ttccaattac atcgctttct aaattaacga aatctccaac
     2581 attctttgtc aagagaatag tgttaatttt agtatgaggt ataatagaaa ccttaaatat
     2641 ttcatcatct aaatatgata tagttaaact tacaccatca atagcaacag aacctttgag
     2701 tatcattgag gataaaagtt ttttatcagg tcgtatactt actaaaactg cattttcatc
     2761 tttttcaaat ttgcagatag ttcctttacc atcaacatga cctgttacta tatgaccacc
     2821 aaatcttgaa gaaagactca tagctctttc aagatttacc ttgtcatttg catttaataa
     2881 acctaaattt gtggaacgaa ttgtctccat cataacatcg gctgtaaatt cattttttcc
     2941 gaggtttgaa acagttagac aaactccatt tacggctata ctatctccaa gatttgtgcc
     3001 atctaatatt ttatttgata gtatggttac ttttccactc ttaccattag cagtaatttt
     3061 tctaagtatt ccaacttctt ctactatgcc agtaaacatc ctaacctcct atatgaatgt
     3121 attaacaaaa atttaattta aaacatctga ttctataaga atatcgccat ctatcaaagt
     3181 tacattattg attgttaact gtgttgaatc tgacaaatga tttattcctt ctccagaaac
     3241 gaatgtaggt gcatctttac cacctataat cttgggtgat agaaataatt tgactttatc
     3301 aactaactta tttctaaaga gactgtcatt gagagtagca ccaccttcaa ctagaacaga
     3361 atcaatgttt aactctccta atttatacat tacaaactcc aaatctacta agttgttttt
     3421 tgaaggagaa attattgttt caacattatt ttcttttaac atagataatt ttatactttc
     3481 tttgcaacat gtgaaaacta tagttttact ggttttatct ttaaccaaat tactattaag
     3541 tggcaacttt aggtgtgtat ctattactat tcttgtagga tgagacactt tttcttgatt
     3601 gagcctacaa gttagtaaag gattatcgtt caaaactgta tttatgccaa ccattatact
     3661 ttggtattta tttctgtatt tatgagttag ataccttgat gattcattag atatccattt
     3721 tgattctagt gattttgtgg caattttacc atctagactt actgctgatt ttacaataca
     3781 aagaggtctt ttgtttttta tatgataaaa aaatgcctca tttaaatctc ttgcttcatc
     3841 ttctaatatt cccacagtaa catcaatatt gttatctttt aattttttta ctccattacc
     3901 acaaacaagt ggatttgggt ctaatgtaga tattacaact ctcttaatct tattttgtat
     3961 aattttatct acacaaggag gcgttttccc ataatgagaa catggttcta agtttacata
     4021 aagagtagag tcttttagac tttgtttagc actgtttata gcatttactt cagcatgatt
     4081 agagccaaat ttctcatgat atcctttgcc tattatatta ctatctttaa caattacaca
     4141 tccaactaat ggatttggat ttacaaagcc ttctccattt ttagccaatt caatagcttt
     4201 tttcatataa taaatatctt tttctttttg attcacaaaa ttcacaatat gtacacctcc
     4261 tgtttaattg gataattttt aaacaaaaaa ccctgagaat taactcaggg tttagaataa
     4321 tctacaataa atgtttaata aatgtagaac aaaattgctc tacaaaaaca ctcattaaat
     4381 atcttcttcc atccagactt tactgtcggc tttggaattt aaccaaatca accaagtttt
     4441 acattggctc gcgggctata ccgccgattg ggaatttcac cctaccccga agattaagta
     4501 ttaaatttat atttagaatg tatcataaat tattttactt tgcaaactat ttttttaaaa
     4561 aatatatgtt aatatataat atagaatgtc tataaacttt gaaataccac gattgtgaat
     4621 ataaaaataa aaatttgaac ataatcagga aagaagtcta attaatttaa attaggagag
     4681 taatatatga ataaaaaact tttagaaata ctatcaaaat actatggata tacaagtttt
     4741 agaaaaggtc aggaatctat aataaattct atcttaagcg aaaaagatgt gctagctatt
     4801 atgccaacag gagggggaaa atcaatatgt tatcaaattc cagctttgat tttagatgga
     4861 atgacaatag taatttctcc acttatatca cttatgaaag accaagtaga tgccttaaag
     4921 actatgggaa ttagtgctgc ttttataaat agttcattaa gtagcaaaga atttaatgaa
     4981 atattaaata atattagaaa aaataattat aaaatactct atattgctcc agagagatta
     5041 gatgcacaag agtttattga gctaataaat aataacaatg taagtcaagt tgcgatagat
     5101 gaagcacatt gtgtatctca atgggggcat gattttaggt tgagttatag aaggatttct
     5161 gattttataa aaaatttgcc taaaagacct atagttacag catttactgc aacagcttca
     5221 gaagaggtaa gaactgatat aataaattta ctgtgtttag aaaatccaga ttattatata
     5281 actggatttg atagagagaa tttatcaata aatatagtaa aatcatctag taaaaataag
     5341 tatattttag attatattca aaatcataaa aatgagtctg gaattatata tgttgcaact
     5401 agaaaggaag ttgaaaatat atataatggt ttatctaaga gaaatatatc tgtatcaaaa
     5461 tatcatgcag gtttatctaa aaatgaaaga agtaaaaatc aagaagattt tataaatgat
     5521 aatgtggata taatggtagc aacaaatgca tttggaatgg gtattgataa acctaatata
     5581 agatgggtta tacattacaa tatgcctcaa agtatagaaa actactatca agaaataggt
     5641 agagctggta gggatggaga aaaaagtgag tgtgtacttt tattttctcc aggagatgta
     5701 catatacaaa aatatttaat tgatattgga gttgaaaatc ctgaaagaaa attatttcag
     5761 cataagaagc ttcaatacat gattgactta gtttacagta attcatgcta tagaaagaca
     5821 atattgagtt attttggaga aaattatata gacaattgca ataattgtag caattgttta
     5881 gtagagggtg aaatagtaga taaaactata gatgcacaaa aagtcatttc atgtgtagct
     5941 agaatgaaaa gaagttatgg tgttactact attgtagatg tgcttagagg ttctaagaat
     6001 aaaaagattt tacagcttgg attaaatact ttgtctacat ataacattat gagagattat
     6061 tctagtgaag acttaaagaa ttttgtaaat acattggttt ctcatggttt tttagattta
     6121 gttgagactc taggcaatgg aaatagaggt agttttccta ctataagatt aaatgagatg
     6181 tctatgaaag ttttaaaagg tgaagtgaaa gtagagttta aagaaattgt tatgacaaaa
     6241 tcattggaag tagaggatga gttatataat gctttaagag aacttagaca ttcaattgca
     6301 agtgaagaaa ggatagctcc atatatggta tttggagatg gtacacttag agccatgtct
     6361 agtagttatc caattaataa agaagaaatg ctagatatct ctggagtagg agaaattaaa
     6421 taccaaaaat atggtagaga ttttgaagca gtaattaaag aatatgtcga aaaaataata
     6481 taaataaaaa aatagatgaa aaaaatgtcg attcaaagaa cgttaatagt gatttcttag
     6541 aggttaatac agataaagtt ttatatgaaa aactgttagt cattagagaa gaatatgcaa
     6601 caaaggaaaa attacctgca tatatgattt tagccaataa ggctttgaaa gaaataagtg
     6661 gaagatatcc acttgatgaa gaacaattaa aagatatttc tggcataggt ggagtaaaat
     6721 ttgaaaaata tggagctagt attttggcag aggttaataa atatgtaaaa gaaaataata
     6781 ttaatgttat ttgggagaaa aagggcaaaa ggaagttaat attagatgga gaaagtagaa
     6841 aaaataatga aatagcatta gatttgctaa atcaaggaaa agatatacaa agtatcagtc
     6901 aagaaataga agtttcactg tcaaccatta ttggatatgt gcatgactat gtaaaggatg
     6961 gacatagtat atcatttgaa ttaggactag aaaattttta taatgaagat aaaaagaaga
     7021 tgattttaga agtttgcgaa aaagttggct atgataattt aaataacata aaaagaaaac
     7081 ttccagattc aataaagtat gaaaatataa gagctgtgat acttgactct tatcttgaaa
     7141 acttaaaaaa taatattata gcagagtaat ttttaactta ataaaaaata aaatttgtat
     7201 tattgtgttg aactaataat tttgctgtgt tatactgaat ttgtaaaaat aatgaaaaat
     7261 tagagctagg ggcgctagaa ttggctagct gagagataaa gccgtaactt acaaacccta
     7321 ataacctgat caagataatg cttgcgaagg gaagcttttt aatataattt tattatataa
     7381 ataggcaaat tattcaatgt taggagaaat ttgtctaagt gtatatacga ttataagagt
     7441 gctttccaaa cgaggaaaag cacttttttt attttcaaaa actataactt taatcttgga
     7501 ggattgtaat atgaactata caacacaaat ggatgctgct agaaaaggca taataactaa
     7561 agaaatggaa atcgtttctc aaaaagaaca ggtagatgta aatgaattaa gagaattaat
     7621 agcaaatgga caagttgtta taccagctaa taaaaatcat aaatctttaa gtgcagaagg
     7681 tgtaggtaaa aatttaagaa caaaaataaa tgtaaatcta ggaatttcaa gagattgtaa
     7741 ggatatagaa aaagaacttg aaaaagttag agtagcaata gacatgaaag ctgaagctat
     7801 aatggattta agtaattatg gcaaaactag agaatttaga gaaaaggttg ttgaaatgtc
     7861 acctgcaatg ataggttcag tacctatgta tgatgcagta ggatatttgg aaaaagaatt
     7921 aaaagatata acagaagaag agtttttaaa tgtaataaga caacatgcta ttgatggagt
     7981 agactttatt actatacatg caggtcttac aagaagtgtt tgccaaaaaa taaaaaatca
     8041 tgagagattg actcatatag tatctcgtgg aggttcttta ttgtttgcat ggatggaatt
     8101 aaataataag gaaaatccta tttatactaa ttttgataaa atattggata tatgtgaaga
     8161 atatgatgtt acattgagtt taggagatgc ttgtagacca ggttgtataa aagattctac
     8221 tgatggtgtt caaattcaag aacttgtagt attaggtgaa cttactaaaa gagcatggga
     8281 aagaaatgta caagtaatga tagaaggtcc tggacacatg gctattgatg aaatagaagc
     8341 aaatgtagta ttagaaaaga gattatgcca tggagcacct ttttatgttc ttggaccatt
     8401 ggttacagat atagcaccag gttatgacca tataacaagt gcaataggag gagctttagc
     8461 atgtgctaaa ggagtagatt ttttatgtta tgtaactcca gcagaacatt taagattgcc
     8521 taatttagat gatatgaaag agggtataat agctgcaaag atagctgctc atgcaggaga
     8581 tatagctaaa aatgttaaag gtgctcgtga atgggataat aagatgagta aagctagagc
     8641 tgatttagac tggtgtgaga tgtttagact tgcaatagac cctgaaaaag ctaagagata
     8701 cagagatgaa tcaactccta ctcatgagga tagttgtact atgtgtggaa aaatgtgctc
     8761 aatgagaaca gttaagaaaa tattaaacaa tgaggaactt aatctaatat aatttttggc
     8821 tagtatgact ggaataaaaa taagctgaaa agaggaggtg atttagtgaa ggttaatggg
     8881 aaggaaattg aatttgaaaa agatttgact gttatagatt tattaaataa atataattta
     8941 aaaagtgata gagttgtagt tgaagtgaat ttagagataa ttgaagaatc taactacaat
     9001 acatatgtat taaaagacga ggacattgta gagcttatta gctttattgg aggtggttaa
     9061 aataaaaata tttgtaaatg aattattaac agatgttgag gaaaatacaa ctgcttataa
     9121 agttagagat agctataaca ataaatgtga tgtattggtg ttaaatggat atccaattaa
     9181 aacagatatg accctttgtg aaaatgataa attaacactt atacaaaaag gagttaagcc
     9241 atcacttgat gaattggaaa gcttgttgat tgctagacat actccaaata tacataataa
     9301 attaaaaaaa gggaaagttg ctatattggg attgggggga cttggttcca atatagctat
     9361 ctctttagct agaataggag tgggagaact tttacttata gattatgatg ttgtagaacc
     9421 atctaattta aatagacagc agtattttat agatgatata ggaaaactaa aaactgatgc
     9481 catgatagaa aatataaaaa aaataaatcc atttataaaa ttaaataaac gagatatttt
     9541 tttaaacaag aacaatatgg atactattaa ggattcagat ttaataattg aggcctttga
     9601 tgatgcttca tgtaaagcac aggtatgtaa ttatgtatta ataaatttaa aagataaata
     9661 tttaatagca tcatctggta tggcaggtta ctatgattca aatataataa ctactaagaa
     9721 gataaaagac aggttttata tatgtgggga ttttgtgaat gaagctaaat ttggtgaagg
     9781 gcttatggct ccaagggttg ccatctgcgc aaatcatatg gcaaatttgg caacgcaaat
     9841 acttatagat atgtaaatat taaaattaga tataaaaaag attgaatatt aaaaaaattt
     9901 aacgtggagg gaaataatat ggataaattg gtacttggtg gacatgaatt taatagcaga
     9961 ttattggttg gaacaggtaa atatggttca aataatatat tgcctgaggt aataaaagaa
    10021 agtggaagtg aaataataac aatggcactt agaagagtgg atttagacaa taaacaagaa
    10081 aacatattaa cgtatattcc aaaagagatg acaatacttc caaatacatc aggagctact
    10141 aatgcagaag aagctgtaag aatagctaga atatctagaa aaatgggatg tggagatttt
    10201 ataaaaatag aagtaatatc agatactaga tatttacttc ctgataatga agaaactata
    10261 aaagctacaa agatacttgc tgatgagggg tttatagttc ttccatatat gacaccagac
    10321 ctttatgctg gaagaagact tatagaagct aatgcagcgg cagttatgcc acttggagct
    10381 ccaattggtt caaatagagg tcttcaaatg aaagaaatga taagaataat gatagatgag
    10441 ttggatatac caataatagt agatgcaggt attggaaaac catctcaagc tatggaggct
    10501 atggaaatgg gagctgatgc agtacttgtc aacactgcta tagcttcagc aggagaccct
    10561 gtacaaatgg ctagagcatt taaattagct gtagaaggtg gaagagaagc atatattgca
    10621 aaaacaggaa atgtgtcaga atttgcaaat gcatcttctc ctttaacagg ttttttaggc
    10681 aatttataga aagtggtgat tggtgatgag tttttatgat gtaatagaaa aatataggga
    10741 ttttgatttt gatggatatt taaataatgt tactgataat gatgttttaa gaagtttatc
    10801 aaaagacaag cttgaagatt ttgatatatt aaatttgctt tctaaaactg cagtaaaaca
    10861 tttagaagat atggcacaaa aagcacataa attaagtgtt caatactttg gtaaaacagt
    10921 atgtttatat acaccaatgt atatagcaaa ttattgtgtt aatcaatgtg tttattgtag
    10981 ctataatata aagagtggaa taaaaagaaa aaaattaact atggatgaaa ttagagaaga
    11041 gggagaagca atttcaaaag aaggtttcaa acatctactt gttttgactg gagaaagtag
    11101 ttttcactca agtgtagaat atataggtga ggctatagaa atattaagag agaaatttcc
    11161 ctctataggt atagaagttt atccaatgga agtagaagaa tataagtaca ttgtagataa
    11221 aggtgttgaa ggattaacag tatatcaaga aacttatgac gaggaaatat ataagagagt
    11281 acatataaaa ggcccaaaat caaattataa atttagacta gatgctcctg aaagaggggc
    11341 aaaagcaggt atgaggactt tatcaatagg tgcactttta gggctaaatg attttagaaa
    11401 agaaactttt tttacaatat tgcatgggaa atacttaaaa acgaaatatc ctcatattga
    11461 gctttcatat tcaacaccaa gaatgagacc ttttaaaggg tgttttgagg aattggtaga
    11521 tataagtgat actgatttag ttcaagctat ggtatgtatg agattatttg accctcatgc
    11581 agctataaat atatccacta gagaaaattt agaaatgaga agtcatataa tacctttagg
    11641 agtaactaaa ttgagtgcag gtgtatctac tgatgtagga ggtcattctc aagatgaaca
    11701 tgatactgct caatttaaga taaatgatga aagtactgtt aaagatgtgg agaaaatgct
    11761 aaactcaatt ggttatcagc atgtgtttaa agattgggaa agattttaaa tgtatctgat
    11821 aacaaacaga aaattatgta gtgaggaacg atatttagaa gttattaaag agtctatatt
    11881 gagtggtgta gaaaatataa taataagaga aaaggattta gaatatcaag agctaagaaa
    11941 attatatatg aaaataaaaa ctaaaatcaa ttgtatagat tttcaagagc aaatatcaga
    12001 tgaaagtttg aaaactaata taaatcaaaa agagtgtaga aataaattca aggttaattt
    12061 tataataaat agtaacattg aattttttga aaaagtggat tgtcaaggta tccatcttcc
    12121 ttttaaatta ttcttgaatt taattgaaaa taagtataat tttaatgaaa ataaaatact
    12181 aggattatct ttacataaag tagaggaagt agattattta gaaaaattaa taagaaatca
    12241 aaatataaaa atagattaca taacattatc acatatatat gaaactaaat gtaaagaagg
    12301 attaaatcca aaaggaattg agcttttaaa agaagctaaa aagattactg atattaaaat
    12361 aattgcactt gggggaattt taccatctaa tgtcaaggaa acattaaaat actgtgatga
    12421 ttttgctata atgtcaacta taatgaggtc taaagatatt aaaaaaacca tatcaaatta
    12481 taatgaaaag ttgaattagt aaatatagta tattgaattt ttaacttaaa taaaaataaa
    12541 aaagttatct tttaaatttt aaaaggtagc ttttttattt tatatctttg ctaataaaaa
    12601 attgtaaaaa gggaaaactt tagtcagaga gattaaacaa tatcctagaa agatttaaaa
    12661 tttagtaaag tatggaggac attataatga ctgacagtaa aaagaaacga tttattatac
    12721 cacacacttt tacaataata tttttactaa tagtcttgat ggcaatattg acttggatag
    12781 taccaagtgg tgaatttagt agagaagatg tagaaggtag aatggtagtt gtaccaggga
    12841 cttatcaaag tgtagaaagt aatcctcaag gatttgcaga tgtttttaaa gcaccaatag
    12901 aaggctttat cgattcagct gaagttgtag gttttgtttt aatagttgga ggtgcttttg
    12961 gtattgtaaa taggactgga gctatagaag caggaatagc ttcggttatc tctaagttta
    13021 agggaaaaga acttcttata attccaatat caatgatttt atttggactt ggaggtacaa
    13081 catttgggat ggcagaagag acattaccat tttatatgat atttgttcca ctcatgacat
    13141 ccttgggata tgattctcta acagcaatag caattgtatt tataggagca gcagcaggag
    13201 ccgccgcttc aacaataaat ccattttcag ttggtattgc acaggcacta gctcaacttg
    13261 ctcctggttc aggagtaact tacagagtag ttatttttat agcatatata ctaataagta
    13321 tagcatttgt tatgtactat gctaagaagg taaaggaaaa tcctgaaagt tcaatagtat
    13381 atgaaataga taaaaataat aaatcaatac ttaatcaaac ttcaacagaa ataaaagaat
    13441 ttacttttaa agaagtatct gttcttgcta tatttggaat agggatggca ataatgattt
    13501 ggggtgtttt aagtcaagga tggtacattc cagaaatatc aatgtgtttt gctgcaatag
    13561 gtgtgctttc tggattggtt ggtagattat ctcaaattga aatctcagaa agttttatag
    13621 atggagcaaa agatttagca tctgcagctc ttgctatagc tttggctcgt ggaatcgtaa
    13681 taattgctca aaatggattt ataatagata ctatattaaa ttccgcagca gcctttctag
    13741 gtgggcttcc aaaggttata tttgtatatt tatcattttt cttggaagct gcattggcat
    13801 ttttaattcc atcatcttca ggtcttgctt cacttacagt acctgtactt gctcctcttg
    13861 gtgatttggt taatatatcg gctcaagtga tagtaaccgc ttatcaattt ggtgtgggtc
    13921 ttacaaactt tataactcca acttcaggag tactgatggg agcacttgca gtagcccata
    13981 ttccattttc aaaatgggta agatttataa tgcctatctt gttgattttg acagctgtat
    14041 ctctagtctt tttaacaata ggtatttata tagggtttta attaagtgta gttttattta
    14101 agatatttag taatggtata aaatgataat atgttttcaa taaattgcca ctaatttaat
    14161 tagtggtaat ttgttttttg tatttaaaaa taaatatatt tacttgtatt ttgaattaat
    14221 atctacttag acattgtttt aattgttata ttttcattta attaagcatt gatttatcat
    14281 tttttatatt tcatataaca atgcaaaaaa taatttttat atagtaaatg acaaaagttt
    14341 acaataaatg tatattttct tactcattcc ttaaaattac tcatttagtt taataactct
    14401 catttcatat gtaaagttgg taaaaaaatt aaaattaaaa gtaaaaaact aaataaatta
    14461 atgttaattt gaaatatata tgaaggtttt tggagaatac ttacttatga taggaaaaaa
    14521 tgttaaaata atagtgtaat caaatataaa ggactgaaat aattaacagt tattaaatat
    14581 taggagtgta aaaatttatg ggattaaaag aatttgattt tattgaagag tctattgata
    14641 tgttgaggac aatgtcacca acattagaaa ctatatcaga tgaaatagaa gagtattttg
    14701 aaaatatctt ggatgaaaag aatcaagaat atataaatgt aacctctaga ataaaatcag
    14761 aatcaagttt aagagaaaag ataattagaa atagatattt aaaaaaatat ggagaagcaa
    14821 gtaatcttat tcataatgtt tctgacttaa taggcctaag aattgagtgt agatttattg
    14881 aggatgaaaa caaaatatat agacttttga gaagatattt taataaaaca gatgacaaaa
    14941 taaactatta taataaagag aataagaata ttaaattaaa actatctgag agacaaccca
    15001 ataagcaaaa aaatggattt gaaatatata aaatagatgg agtttttgcg tatttagata
    15061 gagaagtaaa atttgaactt caaattaaat ctcttgtaaa tgtgttttgg agtgaaatag
    15121 aacataaaat aatttataaa aacaatacat atttacttgc tgataaattt ataaaggata
    15181 tgatggactc tataaagaat aatcttacta tgatagataa tcagctttta agtatttata
    15241 aaaactttca ttcagggaag tcttttaata tgaaagtaag taaaaaagaa attgaaaaat
    15301 tatttgcgaa actagtctat gacgcttttt ctgaaaagat gaataaaagt ataggttttg
    15361 ttgtagattt taaaaaacca tgtgagacta tattgaacta ttcttttaat aaacaagata
    15421 taagtgatga agttttaggt aattttatgc ttgatgagtt tgcaagatta aatgaaattg
    15481 taaacaagga tatagatttt aatgagcaaa tagaatttga aagagaacca acatttgatg
    15541 ataagttttg taaagaccta ggaaatcatt ttagaagtag attaaacaca gaatttccat
    15601 ggaacctatt ttttagaata ttatttgaaa tagagccata taacaatacc aaagactttg
    15661 aaaactttgt agagtttata aaagaaaatg tgctactaga agaaaatagg gagcaattat
    15721 tatgccaatt tgaagaagat agcaaactta taattgaaga tatatatgat tgtatattta
    15781 atagtataag tgagattgat agtgttgaaa ttttatataa ctataatctt gaaaaaataa
    15841 actttacatc aagtgaaatc ataaattgta tatgtagaga atatgagtgt tatggtgaat
    15901 acttagaaga aaaagaaaag cttatgaata catttaaaga aaagattatt caaatctttg
    15961 agtaataggt caatgctgaa gtggcgctaa tgcgccattt ttcaaatata tatgaattaa
    16021 gtaaaattat tttggaggag gcgatttgta tagagaaaac aggtgtaatt ttggcagggg
    16081 gaagaaattc tagaatgggt agagataaag cctttttaga gttacatgat aagcttttta
    16141 ttgaaattgc aatagaagca tttaaaaact ttgatgagtt gataataata tctaataatg
    16201 aagaattata ttctaaatac gatattaaag tttataatga tatagtaaaa gatgttggtc
    16261 caattggagg aatatatact gctcttgaat atgcaaagta tgatatagtt acaattgcat
    16321 gtgatatgcc atatctaaat aatcaaatag tcgaaagaat agctaataaa atgaatgata
    16381 aaagtgtgat ttcagtgaca aatggaaagt tacaaccatt gtgttctgga tataaaaaga
    16441 gtataataaa taaagtatct ttatgtataa gggaaaatga tttaaagctc agaagcttta
    16501 tagataaaat agataaaagt tatatatact ttgatgaaga agatttattt ttaaatgtaa
    16561 acactgttga tgagtatgaa aaattaacta aagtttaatt agctatggtt gtaaaataga
    16621 gtaggattta tatggaggag agtttatgaa tttacttaaa tgcgattctt gggcagtaat
    16681 attaaataat agcgataaag aaagtaaagc atataaaata ttagatgaac ttaaaaggaa
    16741 tatgtacaaa gttgttgcta tagatgaaga gaaaaaacct attgaaggaa tagatgtgta
    16801 tgaatgttta aaagatgttc cacacaatat tgatgttgta gctattattg ataaacaatc
    16861 taagatggat gtgattttag aagaagtaga gcttttggat atacaaaata tgtggtttga
    16921 aaaaggaagc tttagtgaaa tgatgattaa aaagactaaa gatttaaaat taaatataga
    16981 atataattta agtttatatg atgagttgac tagataaaat tatatatctt aataataaaa
    17041 atataattag ttaataaaac atattatttt atagtataga ttggttaata aaagtacaga
    17101 ttggttaatg aaacattaaa ttacaatatt tgttaaaaaa attgtgagtt acatgatata
    17161 atgtattaaa taggatacta aggagttgat atattatgtt aatagtaact acagaaaaag
    17221 tagaaggtaa aaagatatca aaggttttag gattagtgag aggaagtaca ataagagcaa
    17281 aacatgttgg aaaagatata ggagcaagtt ttaagaatct tgttggagga gaacttactg
    17341 gatataatga aatgctcact gaagcaagac aaattgccat aggtagaatg gttgaagatg
    17401 cagaagctaa aggtgcaaac gcagtaatag catttagact gtcttcagct tcagttatgc
    17461 aaggggcagc agaaatgctt gcttatggaa cagcagttgt tttagaagat gataatagta
    17521 ttcttgaaaa ataaaatata aatagttaaa aagaggcatc ttttaaaaat tttatggatg
    17581 ccttttttta tttgaaaaaa ctaatttgag aagaaatttt aactattatg acaataaaat
    17641 tagggtgata ttatataaat aagtaaaatt atattatata atgtatggta tagactttaa
    17701 aaattttatt tgtagagaaa aatatggaca atgttataat aattatagaa attaaaagta
    17761 cttacattca ttatgtatgt gacatgtata attagtttta tatttaatac agttttgaag
    17821 taatatcttc attttgagaa cgttggaata ataaaaaatg tattattata ggtgatataa
    17881 ataaaaaata aatataatat gttatattgc tgatagaaaa gagaataaaa gaaaataggt
    17941 tttattaaaa gagattttta tttataggac ttaatcaatg tatagagggg tgagaacata
    18001 tgtttaatgt tgcaattata acacttagtg ataaaggata tgaaggaaaa agagaagata
    18061 taacaggaaa aaagttaact gaatttgttg aaaatacagg agcttataaa gttactgaat
    18121 atgtacttat aaaagatgat aaggaaatgc taaaggaaaa tattataaga ctttgtaata
    18181 gtaataaaat agatttaatt cttacaaatg gaggtactgg tttttcaaaa agagatataa
    18241 ccccagaagc aactaaggaa gtgttggaaa aagaaatacc aggtctgagc gaatatatga
    18301 gaatgaaatc cacagaaatt actaaaaagg ccatactaag taggggtgta agtggaataa
    18361 gaaataattc tataataata aatttacctg gaagtcctaa aggtgcagtt gaaaatctaa
    18421 gttttataat tgatgtttta gaccatggca tagaagtttt aagaggagaa gctacagaat
    18481 gtgccactaa aaaaagtgaa tagtatataa tctagataga taaaaaatag acaaagaggt
    18541 agataaagta tgattgataa gtatggaaga aaaatagact accttcgtat ttcacttaca
    18601 gataagtgta atttaaggtg tgtttattgt atgccaccag atgtaaaatt tgataaaaat
    18661 tatataaatg aaaatctaag ctttgaagac tacaagttta ttataaaggc tatggctgaa
    18721 caaggtataa caaaaattag atttactgga ggagaacctc ttttatatcc taaattaaat
    18781 gagcttataa aatttacaaa agaagaatgt ggaataaata acataggaat gaccactaat
    18841 gctattgggc tttctgatag aatctttgag cttgaaaaat gtggcttaaa taaagttaat
    18901 ataagtttag attctttgaa ggaatataag tataaatccg taacaagagg aggaaactta
    18961 aaagatgtct taaaatcgat tgaatcttgt ttaaacttag gtataaaagt aaagttaaat
    19021 tgcgttgcta taagtgggtt taatgatgat gagcttaaag attttatgtt tttaacagtt
    19081 aaatcaccaa ttgatgtaag atttatagag cttatgccat taggtgaggc taatagagtt
    19141 tataagaagg gttattttaa tgtaaaagaa atgattgaaa aaatatatgg tttatataaa
    19201 gtcaaaaatg atgaaaaaag tacagcagaa tattatatgt ttaaaggagc taaaggaaga
    19261 ataggaatta taactccatt aagctgttca ttttgtaaca cttgtaatcg tattagactt
    19321 acttctagtg gtgcaataaa attatgtcta cattcaaaag aagaaataga tataaaacca
    19381 tttttacata aaccattgtt atttagagaa tctatgaaag atataataaa acaaaaacca
    19441 gaaaaacatc atttaataga aaataaatgt agtgatacaa ataggcgtat gtatgaaatt
    19501 ggaggataag taatgttaac acatataaat gaaaaagggt atgccaagat ggtggacata
    19561 agtgaaaaag atgatactaa aagaacggcc gtagctacag ctacaattac tcttagtaag
    19621 gaagcattag aaaaagtaaa aaatggtcag ataaaaaaag gagacgtatt gtctgtagct
    19681 caagttgcag gtataatggg agctaaaaat acatcttcaa acataccaat gtgccatcag
    19741 attaaattag ttggatgtga tttagaattt gatgtagatg attctatgtc tgctattaag
    19801 atatacgcaa cctgtaaatc tcttgggaaa actggagtag aaatggaagc tttaaatgca
    19861 tgttctttag cagcacttac aatttatgat atgtgtaaag cagttgataa aaaaatggtt
    19921 ataagtaata tccatcttgt agagaagact ggtggaaaat caggagattt taagttcgag
    19981 taaattaata atatattggg ttaaaatttg gaggaaatat ggcgaaggta gtgtcaataa
    20041 atataagtga gaaaaaaggt gtaattaaag ttcctgtaca atgtgcagag ctaaaaataa
    20101 atcatgggat agttggagat gcacatgcag gaaactggca tcgtcagata agcttacttg
    20161 gaaaagaaag catagataaa atgaaaatga aaggctttga ccaattaaaa tatggagatt
    20221 ttgctgaaaa tgtaactaca gaagggatag aagttttttc cctgcctgtt ggtacaaagt
    20281 taagaatagg gcaatgtgaa gttgaagtaa ctcaaatagg gaaaaaatgt cacaatggat
    20341 gcgaaattaa gaaattgaca ggtgactgtg tgatgccacg agaaggaatt tttgtaaagg
    20401 ttctaaaaga aggaattata aatgtgaatg attcaataga tgtaatctaa tgaagtcact
    20461 attaaaatat aattataagt aaatactatt aagatttaaa tatatatttt aagagagaat
    20521 taattttaat aaaatatttt agttataaat tggaatattg gttatataaa gctatgaatg
    20581 taaaatcata gctttttgtt tttgaatttt aaaatataat a
//
LOCUS       DAEPID010000072        20210 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.072, whole genome shotgun sequence.
ACCESSION   DAEPID010000072 DAEPID010000000
VERSION     DAEPID010000072.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 20210)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 20210)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..20210
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.072"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            <1..582
                     /locus_tag="KR257_002907"
     CDS             <1..582
                     /locus_tag="KR257_002907"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888399.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
                     /protein_id="HBH0031581.1"
                     /translation="NHIGLDLGIKEFCISSCGDFIENPKYLKKSLNKLAKLQRELSRK
                     TIGSLNRNKARLKVAGLQEHIANQRNDFLQKLSTKLIKENDIICIEDLQVKNMIRNRK
                     LSRLISDVSWSEFIRQLEYKANWYGRKIVKVGKFFASSQICNKCGYKNEEVKDLNIRE
                     WICPSCNETHDRDINASINILKEGLRLITIQNK"
     gene            700..1005
                     /locus_tag="KR257_002908"
                     /pseudo
     CDS             700..1005
                     /locus_tag="KR257_002908"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438308.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional oligoribonuclease/PAP phosphatase
                     NrnA"
     gene            1018..1923
                     /gene="truB"
                     /locus_tag="KR257_002909"
     CDS             1018..1923
                     /gene="truB"
                     /locus_tag="KR257_002909"
                     /EC_number="5.4.99.25"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896221.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA pseudouridine(55) synthase TruB"
                     /protein_id="HBH0031582.1"
                     /translation="MNKIISILKPTGMTSHDVVSRVRKILNIKKVGHTGTLDPDASGV
                     LPICIGKATKVCEVILNKDKSYICELTLGISTDTYDASGEILKKVDDFKFSNEDIERA
                     FDTQRGEINQLPPIYSALKVNGKRMCDLVRSGRQSEITLKTRRVNIKDIKILSIKGNK
                     VMFYVECSKGTYVRSICHDIGEYLGCGAHMSFLNRTSSGKFDLDNSITLEELELFYEN
                     KTLDKYLYDIDYVLDSFNYVVLNPNAIKYYSNGGSIDDKRFLKNNFDKDDEFVRVYST
                     DNFLGLGKLSKHNNTISVKSDKMFI"
     gene            2054..2983
                     /locus_tag="KR257_002910"
     CDS             2054..2983
                     /locus_tag="KR257_002910"
                     /EC_number="2.7.1.26"
                     /EC_number="2.7.7.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889098.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional riboflavin kinase/FAD synthetase"
                     /protein_id="HBH0031583.1"
                     /translation="MVIIKSIKEIANIKESVITIGNFDGVHKGHQVLIGKTVEHAKKE
                     NIQSIVFTFANHPVNYFRPNSTKNIISNDDKIKLLEDLGIDIVVIIPFDEYMTKIPAK
                     DFVDEILVKKLKAKKIVIGHDFTFARAKEGNVNLLKSLEHEFGFEVEVIKPIKINDVR
                     VSSTYIRSLVSQGDMANVKEYLGRNYKLEGCVIHSKHLGRTIGFPTANIDLKNNMLVP
                     KRGIYASIVHIGDETYFGATNVGYNPTVNGKTLSIETNILEFDRDIYGENIIVEFLER
                     IRDERKFNSIDDLKNQLYNDTNYVYENYVCKNK"
     gene            3087..3344
                     /gene="rpsO"
                     /locus_tag="KR257_002911"
     CDS             3087..3344
                     /gene="rpsO"
                     /locus_tag="KR257_002911"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002843739.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S15"
                     /protein_id="HBH0031584.1"
                     /translation="MINKSEIIKEYGRAEGDTGSPEVQIALLTARINELNGHLKTHKK
                     DHHSRRGLLKMVGRRRNLLAYLKEKDLEGYRALIAKLGLRK"
     gene            3584..4429
                     /locus_tag="KR257_002912"
     CDS             3584..4429
                     /locus_tag="KR257_002912"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419493.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DegV family protein"
                     /protein_id="HBH0031585.1"
                     /translation="MKIKLVCDSLCDIPDEISEKDYIEIVPLTVIFNDREYIEGVDIK
                     KEEFYKKVKEIKQIPKTSQATYMEFKEVFDKFITEGYHIICMTGAANASGTFQSAMIA
                     KNDVNENEKIHIFDTRNLSLGSGQYVIKACELLEEGLGFEEIIDELENTRSSVRLLFA
                     PYTLDFLKQSGRVPVATALIGNMLNIKPIFFFDNGEAKLVNKVRGIKNIASKLVDIIL
                     EMNEGSLEGKIVTIGCGDNLHDCEILKDEVNKRIKARRVLFTRGGVSICSHTGPDILA
                     ISCSN"
     gene            4554..6665
                     /gene="pnp"
                     /locus_tag="KR257_002913"
     CDS             4554..6665
                     /gene="pnp"
                     /locus_tag="KR257_002913"
                     /EC_number="2.7.7.8"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438316.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="polyribonucleotide nucleotidyltransferase"
                     /protein_id="HBH0031586.1"
                     /translation="MFEHKIFKMDFAGRELSVEIGKICEMASGSCIVRYSDSMVMVNT
                     TKSAKPRDGIDFFPLSVDYEEKLYSVGKIPGGFLKREGKPSEKAILTSRLIDRPIRPL
                     FPKGFRNDVQVVATVLSVDQDCTPDIVAMIGSSIALSISDIPFNGPTGSVCVGLVDGA
                     FVVNPNAEQREKSSMHLVVSGTKEAIMMVEAGADEVPDEVMLDAILFAHQEIKKIVEF
                     IEGIVAEVGKEKMPVELYHAGEEITQLVREFATDKMKKAVQTFEKLERMENMDRVKEE
                     TLAHFEETLEDFEDFVGDIEEVLQDIIKEEVRKLIVHENVRPDNRKLEEIRPIWCETG
                     MIPRAHGSAIFTRGQTQVLNVATLGALGDVQKLDGLDEEENKRYMHHYNFPAYSVGEA
                     RPSRGPGRREIGHGALAERALLPVIPSQEEFPYAIRLVSEVLSSNGSTSQASVCGSTL
                     SLLDAGVPIKDMVAGIAMGLIKHDGKVAVLSDIQGMEDHLGDMDFKVAGTEYGITAIQ
                     MDIKIDGIDKEILQRALKQAKEGRIHILGEMRKTISQPKPELSPYAPKIVKMQINPDK
                     IKDVIGPGGKIITKIIDETGVKIDIEQTGEVFISGIEIDMIKKAQELINNIVVEPEVG
                     KTYKGKVSRIMNFGAFVEILPGKEGLLHISHIAHERVAKVEDVLNIGDEVEVKVTEID
                     EKGRVNLSRKVLLPKPEHKNK"
     gene            6931..7674
                     /locus_tag="KR257_002914"
     CDS             6931..7674
                     /locus_tag="KR257_002914"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419498.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="polysaccharide deacetylase family protein"
                     /protein_id="HBH0031587.1"
                     /translation="MIMMVLNKSKLKKIIILILVVLLVLSGGVMVLKLFNNKPVFNLF
                     NGVDLPYERGTKDKSGYVALTCNIDLGWETEYVESILETLKKENVKITFNVTGKWAEK
                     NKDELLKIKKQGHEIGNHGYKHLDYSTLSYEDNYEQIETSKKIIEEIIGEKTKFFQAP
                     AGSFGPETVKAAKALGYTSIKWDADTIDWKYKDQPEVIIDRMKKKDIKDSSIILMHPT
                     NATTKCIDDIIAIVREKGLKPGKLSDVFK"
     gene            7832..9079
                     /locus_tag="KR257_002915"
     CDS             7832..9079
                     /locus_tag="KR257_002915"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428227.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="insulinase family protein"
                     /protein_id="HBH0031588.1"
                     /translation="MYKTKILENGLTIIGEEIPYLKSITLGIWINAGSRIEEAQVSGI
                     SHFIEHMMFKGTKNRTSKEIASSIDNLGGQINAFTSKECTCYYVKLIDEHIDTGIDVL
                     SDMILNSKFDKNDIDKERLIILEELKMYEDSPDDLSYDLLVENIYANDGLGMNIIGTK
                     ESLYNITRESMLEYLNKYYIPNNAVISIAGNFNFDDMVEKIKSKFGHWEKKNLSIDIS
                     EAKFNPCFISKNKDTEQVNLAMCLKGIPFENDEEVYSMAVVNNIFGGSISSRLFQKIR
                     EEKGLVYSIYSSQTLYRKCGELGIFASMSTENLQDVYNLIKKEIENIRENYLTEKEIS
                     ESKEQLKGNYILDLESTSSRMMSTGKSMLLSKKVKTTDEILECINNVNINSIKKVVDK
                     VFNIENIGTCIVGRDVEKILHLD"
     gene            9114..9359
                     /locus_tag="KR257_002916"
     CDS             9114..9359
                     /locus_tag="KR257_002916"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419503.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YlmC/YmxH family sporulation protein"
                     /protein_id="HBH0031589.1"
                     /translation="MNLSEIAGKEIVNLVTGERLGVIGECDLILDETTGDILALLIPK
                     EKGFFARRKDKSFLEVPWRNVKKIGNDMIIIEYEGYI"
     gene            9369..10592
                     /gene="dapG"
                     /locus_tag="KR257_002917"
     CDS             9369..10592
                     /gene="dapG"
                     /locus_tag="KR257_002917"
                     /EC_number="2.7.2.4"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419506.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aspartate kinase"
                     /protein_id="HBH0031590.1"
                     /translation="MSILVQKFGGTSVESYEKMNEVCKIVKAYKKNDEELQLVLVVSA
                     MGRKGAPYATDTLINLCSAVNDEPSKRELDLIMSCGEIISGTILANLLNAQGIDSVFF
                     TGQQAGIITSDEYSNAKIKYINPKKVKRALDDGKVVVIAGFQGVTDDGEITTLGRGGS
                     DTSAVAIGKALECETVEIYTDVDGIMTADPRVEPNAKVLSFIDYEEVFQMADKGAKVI
                     HPRAVQLAKSGNITLAIKNTMNPTFEGTKIGSLCRHLEDNIEYEQERDFKVAVANKDS
                     VAQVKIKSAEEVFTEVLNEIEKKLITIDMINFFISEKAFVVEDADIKSLKEILDKFEL
                     DYEVNRDCAKVTLICSRIADEMSGIMSKVVRGLSKAGVSLLQTSDSNMTISCLVSEED
                     MHTAVHAIHQQFYLK"
     gene            10705..11439
                     /locus_tag="KR257_002918"
     CDS             10705..11439
                     /locus_tag="KR257_002918"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003433325.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-dependent Clp protease proteolytic subunit"
                     /protein_id="HBH0031591.1"
                     /translation="MKDYREDNEKFDKDNCSEESSCEERECIKQFGTNEMPPQPPKDI
                     QCITIIGEIEGHFIGNPQKKATKYEHIIPMLYSIEESNDVKGVLVVLNTVGGDIEAGL
                     AIAELLNSTSKKVVTLVLGGSHSIGVPLATAGDYSFIAPTATMIIHPVRTTGLVIGIN
                     ETFEYFKKMQDRIIQFIIRTSNIKKDVLEKLMHEKDELVSDVGSVLIGKEAVDYGLID
                     EVGGLKEALKKLRELIKESEEEKNND"
     gene            11562..13973
                     /locus_tag="KR257_002919"
     CDS             11562..13973
                     /locus_tag="KR257_002919"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889104.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA translocase FtsK"
                     /protein_id="HBH0031592.1"
                     /translation="MATKKKKKKKVNTLSFNAEYHNLITIFIGVFLLYSLNSNSMGWI
                     PVLMQNLFKGLFGGLSIAIPFIVIITGLLGFFDGNEYIYRLRKTKLYYIIILFIFVFY
                     GLLNAGTLPVDSPLKGNMFDDVMKLGVSGQGSGLIATTIAYYMSKIFGIAGGWLISIF
                     ALILSVMFIFNISIKDLVSNAKSKSKASKDSNLTFKDKIANMKKSAIDMMTDEVDDTT
                     INKKPGFFKGLMSKGLNNDDEEDEYFEEENSDGVDDKTIKIVGFNKAEDEYLEILEGT
                     QSMPELDVLKELQKATNENPVVDTKPEKKVDIAKPNLNIEKTQPMSIVAEPVNEDYSN
                     YKKPSIELLNKVNKKSDENGKKKVLKNASLLEKTLSDFGVEAKINQVTVGPTITRYEI
                     QPSPGVKVSKIVNLTDDIALSLAAKSIRIEAPIPGKSAIGIEVPNEEAQMVGVREVLE
                     SEEFNNFNSPLAMGLGKDVAGKIIIGDIGKMPHLLIAGSTGSGKSVCVNTLISSILYK
                     ANPDEVKLLLIDPKVVELANYNGIPHLLIPVVTDPKKAANALNWAVTEMNRRYKLFAD
                     AQVKDVTSYNEKAEEKLPKIVIIIDELADLMMASANDVEDYICRLAQMARAAGMHLIV
                     ATQRPSVDVITGVIKANIPSRIAFAVSSQTDSRTILDMGGAEKLLGKGDMLFYPLGAA
                     KPVRLQGAFISESESEKVIDFVKSQVKDGIKYEEDIIETISKVNTSKGSDEDEFLSEA
                     IEFVVESGQASASMLQRRFKIGFNRAARLIDSMEERGIIGASEGSKPRKVLISKQDLQ
                     NLEGE"
     gene            13976..15034
                     /gene="mnmH"
                     /locus_tag="KR257_002920"
     CDS             13976..15034
                     /gene="mnmH"
                     /locus_tag="KR257_002920"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889105.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA 2-selenouridine(34) synthase MnmH"
                     /protein_id="HBH0031593.1"
                     /translation="MSVIKIEKALKLDKVIFVDVRTEGEYEEDHILNAINMPLFKNNE
                     HNEVGTIYKMQGKHEAIQKGFDYVSYKLKDIYLQAAELALNYDNIVIYCARGGMRSGS
                     IVNLLSSLGVNVYQLEGGYKAYRNFVLEYLRHVMDTKNFVSVHGLTGTGKTDLLHLLD
                     EKGIDVLDLEGIAKNSGSTFGFITFDKKPPSQKNFETKLFESIFFSKENYIFVESESK
                     RVGSVTVPNEIFEAMTREGHHILLECDIENRVDRLCRDYIYDKDEGNILILKECINKF
                     RKRLGNKVVDDYIDLLESGEYKELVKRYLLEYYDPLYMHSVEKYKYSKIINFNDTQKA
                     LEDVIDLYESILEGESEC"
     gene            15028..16362
                     /gene="rimO"
                     /locus_tag="KR257_002921"
     CDS             15028..16362
                     /gene="rimO"
                     /locus_tag="KR257_002921"
                     /EC_number="2.8.4.4"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438333.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S12 methylthiotransferase
                     RimO"
                     /protein_id="HBH0031594.1"
                     /translation="MLKIALESLGCSKNLVDAEIMMGILNNKGYKLIGDFEEADVIIV
                     NTCGFIESAKQESIDTIINFAELKKTGNLKLLIVTGCLAQRYSEELKTEIPEIDAIVG
                     TGSYQNIDKILKELSEMHQIVSLNDIEFVFNEDLPRYISTPSYMAYLKIGEGCSNNCT
                     YCIIPKLRGKYRSRKFEDIIKEAKKLAESGVKELVVIAQDTTKYGFDLYGKERLSELL
                     EELAKIDGFKWIRVMYSYPESITEELIQVIKKYDNICSYFDMPIQHASNNILKLMNRK
                     TTKEDILNKINLIRSNIPDAILRTTIIVGFPGETEDDFKQLVDFVEEVKFDRLGAFAY
                     SREEDTPADRLPNHIDEEVKIQRRDTLMMIQQKISEELNDKKIGKTYEVLIEEQIEDN
                     VYTGRTQGDAEEIDSIVYVKSVDNLEVGEFVSVQINDAMEYDLMGDVLYELA"
     gene            16349..16891
                     /gene="pgsA"
                     /locus_tag="KR257_002922"
     CDS             16349..16891
                     /gene="pgsA"
                     /locus_tag="KR257_002922"
                     /EC_number="2.7.8.5"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009905407.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CDP-diacylglycerol--glycerol-3-phosphate
                     3-phosphatidyltransferase"
                     /protein_id="HBH0031595.1"
                     /translation="MNLPNKLTLFRIFLIPVFVLIMLLNVPNKFLIACIIFIIASITD
                     ALDGKIARKYNLVTDFGKFMDPLADKLLVISALTCMIEDHLVSSWMVIIIVARELTVS
                     ILRAIAAADGKVIAAGNSGKLKTITQMVSIVFLLLGAQFENVLILNIGEILILIATLL
                     TLYSGWEYLYKNKELFMSSK"
     gene            17179..18225
                     /gene="recA"
                     /locus_tag="KR257_002923"
     CDS             17179..18225
                     /gene="recA"
                     /locus_tag="KR257_002923"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428218.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase RecA"
                     /protein_id="HBH0031596.1"
                     /translation="MSVDQEKLKALNEALGKIEKDFGKGSVMKLGEATSMSIDVISTG
                     AIGLDIAIGIGGLPRGRIVEVYGPESSGKTTVALSCVASAQKDGGIAAFIDAEHALDP
                     VYAKALGVDVDNLIISQPDTGEQALEIAEALIRSGAIDIIVIDSVAALVPKAEIDGDM
                     GDSHVGLQARLMSQALRKLTGSIKKSNCVAIFINQLREKVGIMFGNPETTTGGRALKF
                     YSSVRLDVRKIDTIKQGDKVIGSRTRVKVVKNKVAPPFKQAEFDIMYGEGISKIGDLL
                     DIAADVDIVKKSGSWYSYNDTKLGQGRENVKKFLEDNLDLTTEIDEKVRAFYNLNEEH
                     EESGISVSKEIVEE"
     gene            18401..19942
                     /gene="rny"
                     /locus_tag="KR257_002924"
     CDS             18401..19942
                     /gene="rny"
                     /locus_tag="KR257_002924"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428216.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribonuclease Y"
                     /protein_id="HBH0031597.1"
                     /translation="MDVIDSVVMIVIGAAVGIIAGYFVRKNISEAKIGQAENLAKEII
                     DKAHHDSETVQKEKLLEAKEEIHKWRTEAERENRERRTEVQKYEKRVVQKEEVLDRKL
                     QNLESKEVNLSEKLKVVEKKEEEVEVIKTQQLEKLESISGITSDKAKEIILTNAERDV
                     RREMSIMIKEIESQAKEEADKKSREIIGYAIQKCAADHVAETTVTVVSLPNDEMKGRI
                     IGREGRNIRTLETLTGIDLIIDDTPEAVILSGFDPIRREIARIALEKLIADGRIHPAR
                     IEEMVEKARKEVDNIIKEYGEQAAFETSVHGIHPELIRLLGRLNYRTSYGQNVLKHSI
                     EVAHIAGIMAAEIGADIRLAKRAGLLHDIGKAVDHEMEGTHVEIGMDLLRRYKESKEV
                     IHAMSTHHGDYEPQTVEAVLVTAADAISAARPGARRETLEAYIKRLEKLEEIANSYEG
                     VEKSFAIQAGREIRIMVKPEAINDEEIHLLARDMTKKIEDELEYPGQIKVSIIRETRA
                     IEYAK"
BASE COUNT         8276 a         2048 c         3904 g         5982 t
ORIGIN      
        1 aatcatatag gtttagattt aggaattaaa gaattttgta tctcaagttg tggagacttt
       61 atagaaaatc ctaagtatct taagaagtca ttaaacaagc ttgctaaatt acaaagagaa
      121 ttatcgagaa aaacaatcgg tagtttaaat agaaataaag caagattaaa agttgcagga
      181 cttcaagaac atatagctaa tcaaagaaat gattttctac aaaaactatc tactaaatta
      241 ataaaagaga atgatattat ttgcatagaa gatttacaag taaagaatat gattagaaat
      301 cgtaaactat ctcgcttaat ttcagatgta tcatggtcag aatttattcg tcaattagaa
      361 tacaaggcta attggtatgg tagaaaaatt gtaaaggtag gtaaattctt tgcaagttca
      421 caaatatgca ataaatgtgg gtataaaaac gaggaagtta aggatttaaa tataagagaa
      481 tggatttgtc ctagttgtaa tgaaactcac gatagagata taaatgcaag tataaatata
      541 ttaaaagaag gattaagact aataacgatt caaaataaat aacttatgta agaaccgtag
      601 gaactacggg gatagcctgt ggagaattag taagacatat tttaatatgc aaaattctgt
      661 gaagcaggaa ccctgtgact ttagtcatgg gaggttcagt caaaggtatc tagtatagtt
      721 ttaactcaag acatgatgaa tagaaataat attagcttta atgatgttga tggaataaca
      781 acatatacaa gagacataaa aggtatagaa gttggaattt tatttaaaga gaaaaaacaa
      841 aatgaaatta aagtgagttt taggtcaaaa aattatgttg atgtaagtga aatagccaag
      901 ttatttggtg gtggtggtca tgtaagggct gctggatgta ctattagaga tagtattgat
      961 aatgcaaaga aaatggtact agaggcagtg ttaaaatcaa tttaaggtga cagtaaaatg
     1021 aataagatta taagtatatt gaaacccaca ggtatgacat ctcatgatgt tgtaagtaga
     1081 gtgagaaaga ttttaaatat aaaaaaagtt ggtcatacag gtactcttga cccagatgct
     1141 tcaggtgttt taccaatctg tatagggaaa gctacaaaag tatgtgaagt tattttaaac
     1201 aaagataaat cgtatatatg tgagcttact ttaggtataa gtacagatac ttatgatgct
     1261 tcaggtgaaa ttttaaaaaa agttgatgat tttaaattta gtaatgaaga catagaaaga
     1321 gcttttgaca cacaaagagg agagataaat caacttcctc caatttattc agctttaaag
     1381 gtaaatggaa agagaatgtg tgatttagta agaagtggta gacaatctga aattacttta
     1441 aaaacaagaa gagtaaatat aaaagacata aaaatactaa gtataaaagg taataaagta
     1501 atgttttatg ttgagtgttc taaagggact tatgtgagaa gcatttgcca tgatatagga
     1561 gaatatctag gttgtggagc tcatatgtcg tttttgaata gaacatcttc tggtaaattt
     1621 gacttagata attcaataac attagaagaa ttagaattat tttatgaaaa taaaacttta
     1681 gacaaatact tatatgatat agattatgtc cttgattcgt ttaattatgt tgtattaaac
     1741 cctaatgcta taaaatatta tagtaatggt ggctcaatag atgataaaag gtttttaaaa
     1801 aataatttcg ataaagatga tgaatttgta agagtataca gtacagataa tttcttagga
     1861 ttaggaaaat tatcaaaaca caataataca ataagtgtta aaagtgataa gatgttcata
     1921 taaccaatgt atttaaaaaa acaacaaaag agatagtact ataataactt ctatagtcta
     1981 tctcttttac ttatgctata atagtttgtg aataagttaa gagtaaatta tattttagcg
     2041 gggaacattt attatggtga ttataaaatc tataaaagaa atagcaaaca taaaagaaag
     2101 tgtcattacc ataggaaatt ttgatggtgt acacaaagga catcaagttc ttataggaaa
     2161 aacagttgaa catgcaaaaa aagaaaatat acagagtatc gtatttacat ttgcaaatca
     2221 tcctgtaaat tactttagac caaactcaac aaaaaatatt ataagcaatg atgataaaat
     2281 aaaattatta gaagatttgg gaatagatat agttgtaatc ataccatttg atgagtatat
     2341 gactaaaata cctgcaaagg atttcgtaga tgagatacta gtaaaaaaat taaaagctaa
     2401 aaagatagta attggacatg actttacatt tgcaagggca aaagaaggca atgttaatct
     2461 attaaaaagc ttagaacatg aatttggttt tgaggtagaa gtaataaaac ccatcaaaat
     2521 caatgatgta agagtgagta gtacttatat tagaagttta gtatcccagg gtgatatggc
     2581 taatgtcaag gaatatttgg gtagaaatta caagttagaa ggttgtgtta tacattctaa
     2641 acaccttgga agaactatag gattcccaac ggcaaatatt gaccttaaga ataatatgct
     2701 cgttccaaag agaggtattt atgcttctat tgtacatatt ggagatgaga cttattttgg
     2761 tgctacaaat gtaggctata acccaacagt taatggaaaa actttgtcta ttgaaacaaa
     2821 tattttagag tttgatagag atatttatgg ggaaaatata attgttgaat ttttggaaag
     2881 aataagagat gaaagaaagt ttaattcaat agatgactta aaaaatcaat tgtataatga
     2941 tacaaattat gtgtatgaaa actatgtttg caaaaacaag taatgtatga taaaatgatt
     3001 aaggaaaata accattactc agcatttgaa tactccaatc aatgcttagt aataggcgtt
     3061 tctaaaaaaa tacggaggta atctaaatga taaacaaatc agaaataata aaagaatatg
     3121 gaagagctga aggggatact ggttctccag aagtacaaat agctttatta acagctagaa
     3181 taaacgagtt aaatggacat ttaaaaactc ataagaaaga ccaccattca agaagaggac
     3241 tattaaaaat ggttggtaga agaagaaact tattagctta cttaaaggaa aaagatcttg
     3301 aaggatatag agcattaata gctaaattag gattaagaaa gtaatttcat tctttataaa
     3361 aaagcaggta tagtgtatac ctgctttttt atagttaatt cattataaag taaaatagtt
     3421 aataataaaa gtagtttata tgttataaaa aattataaaa tgaataatat tgggtaagaa
     3481 tattaaaata gtatacaaat acataatcaa tttaaaagga aagacaggat aaatatagaa
     3541 attttataac aggataatta gttggaataa ggaggatatt attttgaaaa taaagttagt
     3601 atgcgatagt ttgtgcgata ttccagatga aatatcagaa aaagattata tagagatagt
     3661 tccacttaca gttattttta atgataggga atatatagaa ggagtagata taaagaaaga
     3721 agagttttat aaaaaagtaa aagaaatcaa gcaaatacct aaaacttcac aagctacata
     3781 tatggagttt aaagaagtgt ttgataagtt cataacagaa ggttatcata taatctgtat
     3841 gacaggggct gcaaacgcat caggaacttt tcaaagtgct atgatagcta aaaatgatgt
     3901 aaatgaaaat gaaaaaatac atatatttga tactagaaat ttatctctag gtagtggaca
     3961 atatgttata aaggcatgtg aacttcttga agaaggactg ggatttgaag aaattataga
     4021 tgaattagaa aatactcgca gtagtgtaag attgcttttt gcaccatata cacttgattt
     4081 tttaaagcag agtggaagag ttccagttgc aactgctttg ataggaaata tgttaaatat
     4141 aaagcctata tttttctttg ataatgggga agctaagttg gtaaataagg ttagaggaat
     4201 aaagaatata gcaagtaaat tggtcgatat aattttagaa atgaatgaag ggtctttaga
     4261 aggaaaaatc gtcacaatag gttgtggaga taatttacac gattgtgaaa tattaaaaga
     4321 tgaagtaaat aaaagaataa aagcaagaag agtattattt actcgaggag gagtttctat
     4381 ttgctctcat acagggccag atatattggc tataagttgt tctaattagt agtaatataa
     4441 ggtttttgca tatatatgtg aagataattt tatattgtta atttatagta tttttgataa
     4501 tatagtaaat agagtgatat acgtgttttt taataagagg aggacaagca ttaatgtttg
     4561 aacataaaat atttaaaatg gattttgcag gaagagaact ttctgtagaa ataggaaaga
     4621 tttgtgaaat ggctagtggt agttgtatag ttcgatacag tgatagtatg gtaatggtaa
     4681 atacaactaa atcagccaaa cctagagacg gaatagactt ttttccttta agtgtggatt
     4741 atgaagaaaa attatactct gtaggtaaga tacctggagg ttttttaaag agagaaggca
     4801 agccttcaga gaaagctata cttacatcaa gattgataga tagaccaata agacctttat
     4861 tcccaaaagg atttagaaat gatgttcagg tagttgcaac agttctatca gtagaccaag
     4921 attgtacacc agatatagta gcaatgatag gttcttcaat agccctttct atatcagaca
     4981 taccatttaa tggaccaaca ggttcagtat gtgttggcct tgtagatggt gcatttgttg
     5041 taaatccaaa cgcagagcaa agagaaaaaa gttcaatgca tctagttgtt tcaggtacaa
     5101 aggaagcaat aatgatggtt gaagccggag ctgatgaagt tccagacgag gtaatgcttg
     5161 atgctatttt atttgctcac caagaaataa aaaaaatagt tgagtttata gaaggtatag
     5221 ttgcagaagt tggaaaagaa aaaatgcctg ttgaattata ccatgcagga gaagaaataa
     5281 ctcaattggt tcgcgaattt gcaactgata agatgaaaaa agcagttcag acttttgaaa
     5341 agttagagag aatggaaaat atggatagag ttaaagaaga aactttagct cactttgaag
     5401 aaactttaga agattttgaa gattttgttg gagatataga agaagtatta caagatataa
     5461 taaaagaaga agtaagaaaa cttatagtac atgaaaatgt aagaccagat aatagaaaac
     5521 ttgaagaaat aagacctata tggtgtgaaa ctggcatgat acctagagct catggttcag
     5581 ccatatttac tagaggacaa actcaagtac ttaatgttgc tactttaggt gctttaggag
     5641 atgttcaaaa actagatggg ttagatgaag aagaaaacaa gagatatatg catcattata
     5701 atttccctgc atatagtgtt ggagaagcta gaccatcaag aggaccagga agaagagaaa
     5761 taggacatgg tgctttagca gaaagagctt tattaccagt aataccatct caagaagaat
     5821 ttccttatgc tattagatta gtttctgaag tattaagttc aaatggttct acatctcaag
     5881 caagtgtatg tggctcaaca ttatctttac ttgatgcagg tgtacctata aaagatatgg
     5941 ttgcaggtat agcaatggga cttataaagc atgatggtaa ggttgcagtg ctttcagata
     6001 tacaaggtat ggaagaccat ttaggcgata tggactttaa agtagctgga acagagtatg
     6061 gtataacagc aatacaaatg gatataaaaa ttgatggtat agataaagaa attctacaac
     6121 gtgctttaaa acaagctaaa gagggtagaa tccatatact aggagagatg agaaaaacta
     6181 tatctcagcc aaaaccagaa ctttcaccat atgcacctaa gattgttaaa atgcaaataa
     6241 atcctgacaa gataaaagat gtaataggac ctggtggaaa gataataact aagataatag
     6301 acgaaactgg agttaagata gatattgaac aaactgggga agtatttata tcaggtattg
     6361 agattgatat gattaagaaa gctcaagaac ttataaataa tatagtagtt gaaccagaag
     6421 taggaaaaac ttataaaggt aaggtaagta gaataatgaa ctttggagca tttgttgaga
     6481 tacttccagg aaaagaagga ttacttcata tatctcatat agctcatgaa agagttgcca
     6541 aagttgaaga tgtattgaat ataggggatg aagttgaagt taaagttaca gagattgatg
     6601 aaaaaggaag agttaattta tcaagaaaag ttcttttacc aaaaccagaa cataaaaata
     6661 aataacttat tatataatta aaagcaaagt cttaggattt tgctttttta aatacaaaaa
     6721 agtagataat tttaaaatga tagttatgga tggcttatag ttctttttct gtcaggcttt
     6781 actcttataa agaagctatt taaaagctga ttaatagaga gctttattga tatatataga
     6841 atcacttaag ttatatttag tgcataaaca gagcttattt ttaatagtat taaataagaa
     6901 acaatttgta cataattagg gggagtttta atgataatga tggtacttaa taagagtaag
     6961 ctcaaaaaaa tcataatact aattttagta gtgttattag tattatcagg aggggtaatg
     7021 gtattaaagt tatttaacaa caagccagta tttaatttat ttaatggtgt agatttacca
     7081 tatgaaagag gtacaaagga taaaagtgga tatgttgcat taacctgtaa tatagacctt
     7141 ggatgggaaa cagagtacgt agaatccatt ttagaaacac ttaaaaaaga aaatgtaaag
     7201 attacattta atgtaactgg aaaatgggca gaaaagaata aggatgaatt attaaagata
     7261 aaaaaacaag gacatgaaat aggtaatcat ggatacaaac atttagatta ttctacatta
     7321 tcatatgaag acaattatga gcaaatagag acctctaaaa agataattga agaaattata
     7381 ggtgaaaaaa ctaaattttt tcaagcacca gcaggttctt ttggtccaga aacagtaaag
     7441 gctgctaaag cattagggta tacttctatc aaatgggatg ccgatactat agattggaaa
     7501 tacaaagacc aaccagaggt aatcattgat agaatgaaga aaaaagacat taaagatagt
     7561 agtataattt taatgcatcc aaccaacgca acgacaaaat gtatagatga tattatagct
     7621 attgtaagag aaaaaggact aaaaccagga aaacttagtg atgtatttaa gtagacaaag
     7681 tataaatatt tggttaagat tgtataagtt gtagttgaat taattaaaag actgacttat
     7741 aatgtaatac atataaaaaa taaatataat taaaacatag tgttttcaat aatccaatat
     7801 gaaacaaaga ataaattgtt aggagaatgt aatgtataag acaaaaatac tggaaaatgg
     7861 gcttacaata attggtgaag aaataccata tctaaagtca ataacattag gtatttggat
     7921 aaatgcaggc tctaggatag aagaagcaca ggtgagtgga atttctcatt ttatagagca
     7981 tatgatgttt aaaggaacca aaaacagaac atcaaaagag attgctagtt caatagataa
     8041 tttgggtggt caaataaatg catttacaag taaagaatgt acatgttatt atgtaaaact
     8101 aatagatgag catatagata caggaattga tgtattgagt gatatgatac taaattctaa
     8161 atttgataaa aatgatatag ataaggaaag acttataata ttggaagaac ttaagatgta
     8221 tgaagactct ccagatgact tatcttatga tttattagtg gaaaatatat atgctaatga
     8281 tggattagga atgaatataa ttgggacaaa agaatctctg tacaatataa ctagagaatc
     8341 catgttagaa tacttaaata agtattatat tccaaataac gctgttattt ctatagctgg
     8401 aaactttaac tttgatgata tggtggagaa aatcaaatca aaatttggac actgggaaaa
     8461 gaaaaattta agtatagaca taagtgaggc taagtttaat ccttgcttta tatcaaaaaa
     8521 taaagatact gaacaggtga acttagctat gtgcctaaaa ggtattcctt ttgaaaatga
     8581 tgaagaagtc tattcaatgg cagtggtaaa taatattttc ggtggaagta taagctcaag
     8641 gctttttcag aaaataaggg aagaaaaagg tttagtatat tcaatatact catcacagac
     8701 attatatagg aaatgtggtg aattaggtat atttgcaagc atgagtacag aaaatttaca
     8761 agatgtatat aatttaataa agaaagaaat tgaaaatata agagaaaact atcttacaga
     8821 aaaagaaata tctgaaagca aggaacagtt aaaaggaaat tatatattgg atttagaaag
     8881 tactagcagt agaatgatgt ctactggtaa atctatgtta cttagcaaaa aagtaaaaac
     8941 tacagatgaa atacttgaat gtataaataa tgttaatatt aattcaataa agaaggttgt
     9001 tgataaggta ttcaatatcg aaaatattgg tacatgtata gttggaagag atgtagaaaa
     9061 gattctacac ttggattaat attgaaaaaa gtaaatctct ggaggtataa aatatgaatt
     9121 tatctgaaat agcaggtaag gaaatagtta acttggtcac aggagaaaga ttgggggtca
     9181 ttggagaatg tgaccttata ctagatgaaa ctacaggcga tatattagcg cttctaattc
     9241 caaaagaaaa aggatttttt gccagaagaa aagataagtc atttttagaa gtaccatgga
     9301 gaaatgtaaa aaaaataggt aatgacatga taattataga atatgaggga tatatttagg
     9361 aggaaaaaat gagtatttta gtgcaaaagt ttggtgggac atcagtagaa tcatatgaaa
     9421 aaatgaatga agtatgtaag atagtaaaag catacaaaaa aaatgatgaa gaattacaat
     9481 tagtattagt agtttcagca atgggaagaa aaggagctcc atatgctaca gatacactta
     9541 taaatttgtg tagtgcagta aatgatgagc caagtaaaag agaacttgat ttaataatgt
     9601 cttgtggaga aataatatca ggaacaattc ttgctaattt attgaatgca caggggatag
     9661 attctgtttt ctttactggt cagcaagcag gtataattac aagtgatgaa tattctaatg
     9721 caaagataaa gtatataaat cctaaaaagg taaaaagagc tttagatgat ggtaaggttg
     9781 tagttatagc tgggttccag ggtgtaacag atgatggaga aataactact cttggaagag
     9841 gcggaagcga tacatcagca gttgctattg gtaaagcttt agaatgtgaa acagttgaaa
     9901 tttacactga tgtggatggt ataatgactg cagaccctag agtagaacca aacgctaaag
     9961 tattgagttt tatagactat gaggaagtat tccaaatggc tgacaaaggt gcaaaagtaa
    10021 tacatccaag agcagtacag ttggctaaaa gtggaaatat aactttagcc ataaagaata
    10081 caatgaatcc aacttttgaa ggtacaaaaa taggttcttt atgtagacac ttagaagaca
    10141 atatagaata tgaacaagaa agagatttta aggttgctgt tgcaaataaa gatagcgtag
    10201 cacaagttaa gattaagtca gcagaagaag tgtttacaga agtattaaat gagatagaaa
    10261 agaaacttat aactatagat atgataaatt tctttatatc agaaaaagca tttgttgtag
    10321 aagatgctga tataaaatca ttaaaggaaa tactagataa atttgaatta gattatgaag
    10381 taaatagaga ctgtgctaag gtaacattga tatgttcaag aattgctgat gaaatgtctg
    10441 gtatcatgtc aaaggtagtt agaggattat caaaagcagg ggtatctctt ttacaaacat
    10501 cagactcaaa tatgactata tcttgtttag ttagtgaaga agatatgcat acagcagtac
    10561 atgctataca ccaacaattt tatttaaaat aaactgtata atacaattat tttttaatca
    10621 aatttaagaa tttcatatat atcttaatat atttgattta tttggtaaaa ctaaattaaa
    10681 tataattttg ataggagttt ttttatgaaa gattatagag aagataatga aaaatttgat
    10741 aaagataatt gtagtgaaga atctagttgc gaagagagag aatgtataaa gcaatttggt
    10801 accaatgaaa tgccacctca acctcctaaa gatattcaat gtataactat aattggagaa
    10861 attgagggac attttatagg aaatcctcaa aaaaaagcta caaagtacga gcatataatt
    10921 ccaatgctat actcaattga ggaaagtaat gatgttaaag gagtgttagt tgttttaaac
    10981 actgttggag gagatattga agcaggttta gctattgcag aacttttaaa cagtacatct
    11041 aaaaaagtag ttactcttgt tctaggagga agtcatagta taggtgttcc tcttgctaca
    11101 gcaggagatt actcatttat agcaccaaca gcaaccatga ttatacatcc agtgcgaact
    11161 actggtcttg tgattggtat aaatgagact tttgaatatt ttaaaaagat gcaagataga
    11221 ataattcaat ttataataag aacatcaaat atcaaaaaag atgtacttga aaaacttatg
    11281 catgaaaaag atgaacttgt aagtgatgtt ggtagtgtat taataggaaa agaagctgtg
    11341 gattatggtc ttatagatga agttggagga ctaaaagaag cacttaaaaa attaagagag
    11401 cttataaaag aatctgagga agaaaaaaat aatgattaaa atttgtttaa ataataaaat
    11461 ttatgatata atgatgtaat aaagtaggag tgttagtgtt aaggcattag cactttttgc
    11521 tgtgaagggg taaaacttgc taaaaataag gagtgatatt aatggccacg aaaaagaaga
    11581 aaaaaaagaa ggtaaatacc ttaagtttta atgcagaata tcataattta ataacaatat
    11641 ttataggtgt atttttatta tatagtttaa attctaattc tatgggatgg atacctgtgt
    11701 taatgcaaaa tctttttaag ggactatttg gagggctttc aatagcaata ccatttatag
    11761 taattataac aggactttta ggattttttg atggaaatga atatatatat aggctaagaa
    11821 agactaaact atactacata attattttat ttatatttgt attttatgga ttattaaatg
    11881 caggaactct tcctgtagat agcccactaa aaggtaacat gtttgatgat gttatgaaat
    11941 tgggtgtaag tggacaaggt agtggtttga tagcaacaac tattgcgtat tatatgagta
    12001 aaatatttgg tatagcaggt ggatggttaa taagtatctt cgcacttata ctttctgtaa
    12061 tgtttatatt taatatttct ataaaagatt tggtgtcaaa tgcaaaatca aaatctaaag
    12121 catctaaaga cagcaattta acgtttaaag ataaaattgc aaatatgaaa aaatctgcaa
    12181 tagatatgat gactgatgaa gtagatgata ctactataaa taaaaaacca ggtttcttta
    12241 aagggttaat gtcaaaaggt cttaataatg atgatgaaga agatgaatat tttgaagaag
    12301 aaaatagtga tggtgtagat gataaaacta taaaaatagt tggatttaat aaggcagaag
    12361 atgagtattt agaaatatta gaaggaactc aaagtatgcc agagttagat gttttaaaag
    12421 aattacaaaa agctaccaat gaaaatccag ttgtagatac taaaccagaa aaaaaagttg
    12481 atatagctaa acctaattta aatatagaaa aaactcaacc tatgagtatt gtagcagagc
    12541 cagttaatga ggattattca aactataaaa agcctagcat tgagctttta aataaagtaa
    12601 ataagaagtc tgatgaaaat ggtaaaaaga aagtgttgaa aaatgcttct cttttagaaa
    12661 agacactatc agattttgga gtggaagcaa aaattaatca agttacagtt ggacctacta
    12721 taacaagata tgaaatacaa ccaagtccag gagtcaaggt aagtaaaatt gtaaatttaa
    12781 ctgatgatat agctttaagt ttagcagcta aaagtataag aattgaagcc ccaattcctg
    12841 gtaaaagtgc aattggaata gaagttccaa atgaagaagc tcaaatggtt ggtgtgagag
    12901 aagttctaga aagtgaagaa tttaataatt ttaactctcc tcttgcaatg ggacttggaa
    12961 aagacgtagc aggaaaaatt ataattggag atataggtaa gatgccacac ttactaatag
    13021 ctggttctac aggttcagga aagagtgtgt gtgtaaatac attaataagt agtattttat
    13081 ataaggcaaa tcctgatgaa gtaaaattac tattaataga cccaaaagta gttgaacttg
    13141 caaattataa tggaatacca catctattga taccagtagt tactgaccct aaaaaagctg
    13201 caaatgcttt aaattgggca gttacagaga tgaatagaag gtacaaatta tttgcagatg
    13261 ctcaagtaaa agatgtaaca agttataatg agaaagcgga agaaaaactt cctaaaatag
    13321 taataataat agatgagtta gcagatttaa tgatggcaag tgcaaatgat gtagaagatt
    13381 atatttgtag attagctcaa atggcaagag ctgctggaat gcacttgatt gtagcaactc
    13441 aaagaccatc tgttgacgtt ataacagggg taataaaggc taatatacca tctagaatag
    13501 catttgcagt atcatctcaa actgattcaa gaacaatcct tgatatgggt ggtgcagaga
    13561 agcttctagg taaaggtgat atgttattct atccacttgg tgcagcaaaa ccagttagac
    13621 ttcaaggggc attcatatca gagagtgagt cggaaaaagt aatcgatttt gtaaaaagtc
    13681 aggttaaaga tggaataaaa tatgaagaag atataattga aactatatct aaggttaata
    13741 cttcaaaggg tagtgatgag gatgagtttt tgagtgaagc gatagaattt gtcgtggaaa
    13801 gtggtcaagc atctgcctct atgctacaga gaagatttaa aataggattc aatagagcag
    13861 ctagacttat agattctatg gaagaaagag gaataattgg agcaagtgag ggaagtaaac
    13921 cgagaaaggt attaataagc aaacaggatt tgcagaattt agaaggtgaa tagaattgtc
    13981 agttataaaa atagaaaaag cacttaagct agataaagta atatttgtag atgtgagaac
    14041 tgaaggagaa tatgaagaag accatatatt gaatgcaatc aatatgcctc tttttaaaaa
    14101 taatgaacat aatgaagttg gaacaattta taagatgcag ggaaaacatg aagcaataca
    14161 aaaaggattt gactatgtat cgtataaatt aaaggatata tatttacaag cagcagaact
    14221 tgcattaaat tatgataata ttgtcatata ttgtgcaaga ggcggaatga gaagtggcag
    14281 tatagtaaat ttattatcat cattaggtgt aaatgtatat caacttgaag gtggatataa
    14341 ggcttataga aattttgttt tagagtattt aaggcatgta atggatacaa aaaactttgt
    14401 atctgttcat ggattgactg gtacaggaaa gactgatttg ttacatttat tagatgaaaa
    14461 aggaatagac gtgctggatt tagaaggcat agctaaaaac agtggttcta cctttggttt
    14521 tataactttt gataaaaagc caccatctca aaagaacttt gaaacaaaac tatttgaaag
    14581 tatatttttt tcgaaagaga attatatatt tgtcgagagt gaaagcaaac gagttggaag
    14641 tgttacagtt ccaaatgaaa ttttcgaggc aatgacacga gaaggacatc atatattatt
    14701 agaatgtgat attgaaaata gagttgatag actttgtaga gattatattt atgataaaga
    14761 tgaaggtaat atattgattt taaaagaatg tataaacaag tttagaaaaa gattgggtaa
    14821 taaagtagta gatgattata ttgatttatt agaatcaggt gaatataaag aacttgtaaa
    14881 aagatatctt ttagaatact acgacccact ttatatgcat tcagtagaga aatataagta
    14941 tagtaagatt ataaatttta atgatacaca aaaagcttta gaagatgtta tagacttata
    15001 tgagagtata ttggaaggag aaagtgaatg ttaaaaatag cattggaatc attaggatgc
    15061 tcaaaaaatt tagtagatgc agaaataatg atgggaattt taaataacaa aggctataaa
    15121 ttaattggag attttgaaga agctgatgta attatagtaa atacatgtgg gtttatagag
    15181 tcagctaaac aagaatctat agatacgata ataaactttg cagagttaaa aaaaactggc
    15241 aatttgaagt tgttgatagt aacagggtgt ctagcccaaa gatattctga agaattaaaa
    15301 actgaaattc ctgaaataga tgctatagta ggaacaggaa gctatcaaaa tatagataaa
    15361 atacttaaag aattaagtga aatgcatcaa attgtaagcc ttaatgatat agagtttgta
    15421 tttaatgaag atttaccaag atatatatct acacctagct atatggccta tttaaaaatt
    15481 ggagaaggat gttccaataa ttgtacttat tgtataatac caaaactaag aggtaaatat
    15541 agaagtagaa aatttgaaga tataattaaa gaagctaaga aattagctga atctggagta
    15601 aaagaacttg tggttatagc acaggatacg acaaagtatg gttttgattt atatggaaaa
    15661 gaaagattat cagaactttt agaagaactt gcaaaaatag atggatttaa gtggataagg
    15721 gttatgtatt catatccaga atctataaca gaagaattga tacaagttat aaagaaatat
    15781 gataatatat gtagttactt tgatatgcca atacagcatg caagtaacaa tattttaaaa
    15841 ttaatgaata gaaaaactac taaagaagat atattaaata aaatcaatct gataagaagt
    15901 aatataccag atgctatact tagaactaca ataatagtag ggtttcctgg tgaaacagaa
    15961 gatgacttca aacaacttgt ggactttgtt gaagaggtta aatttgatag acttggtgca
    16021 tttgcatatt caagagaaga agatacacca gcagatagat tgccaaacca tatagatgaa
    16081 gaagtaaaaa tacaaagaag agatacttta atgatgattc aacaaaaaat atctgaagaa
    16141 cttaatgaca aaaagatagg aaaaacttat gaggtgttaa tagaagaaca gatagaagat
    16201 aatgtatata caggaagaac acaaggtgat gcagaagaaa ttgacagtat agtgtatgta
    16261 aaaagtgtag acaatcttga agtaggagaa tttgtaagtg ttcaaataaa tgatgcaatg
    16321 gaatacgatt taatgggaga tgttttatat gaacttgcct aacaagttaa ctttgtttag
    16381 aatattttta ataccagtat ttgttttaat tatgttgctc aatgtaccaa ataaattttt
    16441 aatagcttgt attattttta taatagcttc aattactgat gctttagatg gaaaaatagc
    16501 tagaaaatac aatctagtca ctgactttgg aaaatttatg gacccattag cagataagtt
    16561 attggttatt tcagcactta catgtatgat agaagaccat cttgtaagta gttggatggt
    16621 aattataata gtggctagag agcttacagt tagcatatta agagctatag ctgctgctga
    16681 tggaaaagta attgctgctg gaaacagtgg aaaacttaaa acgataactc aaatggtatc
    16741 tatagtgttt ttattgttag gtgctcagtt tgaaaatgta ttgatattaa atattggtga
    16801 aattctcatt cttatagcta cactacttac attatattct ggatgggaat atctatataa
    16861 aaataaagag ctttttatgt cttctaagta aaaaattatg ctttaataaa taaaaactaa
    16921 tgattaataa ataaaaaata acaacttaaa attttaaaaa tgtaaaaaag ggtatactat
    16981 tatagtatac ctcttttcat tttaagaata ttttcttttg tgtatataat tattaataat
    17041 ggtttataaa taaaatgtaa tgaataaaaa tataatcatt agtagcgttt ttaaattgac
    17101 taggtttgat ttatgttata taattaatat ataacaagag aacaaatgtt tgtagataaa
    17161 tgaagggatg gtatagagat gagtgtagat caagaaaaat taaaagcgtt gaatgaagct
    17221 ttaggtaaaa ttgaaaaaga ttttggtaaa ggttcagtaa tgaaattggg agaagcaaca
    17281 tctatgtcta tagatgttat atcaacagga gcgattggtt tagacatagc tattggtata
    17341 ggaggtctac ctagagggag aatagttgaa gtatatggtc cagaatcttc tggtaaaact
    17401 actgttgcgc ttagttgtgt agcatcagct caaaaagatg gaggaatagc tgcatttata
    17461 gatgcagaac atgcacttga cccagtatat gcaaaagctt tgggtgtgga tgttgataac
    17521 ctaataatat ctcaaccaga tacaggtgaa caggctttag agatagcaga ggcattgata
    17581 agaagtggag cgatagatat aatagtaata gactcagtag cagcattagt tccaaaggct
    17641 gaaatagatg gagatatggg tgattctcat gtaggtttac aagctagact tatgtcacaa
    17701 gcacttagaa agttaactgg ttcaattaaa aaatcaaatt gtgttgctat atttataaac
    17761 cagttaagag agaaagtagg aataatgttt ggaaacccgg aaactactac tggaggacgt
    17821 gcactaaaat tctattcatc agttagattg gatgttagaa aaatagatac aataaaacaa
    17881 ggtgataaag ttataggtag tagaactaga gttaaagttg ttaaaaacaa agtagcacca
    17941 ccatttaagc aagctgaatt tgatataatg tatggagaag gaatttcaaa aattggagac
    18001 cttttagata tagctgctga tgtagatata gttaaaaaat caggttcatg gtatagttac
    18061 aatgatacta aacttggaca aggaagagaa aatgttaaaa aattcttgga agataattta
    18121 gatttaacta ctgaaataga tgagaaagtt agagcatttt acaatttaaa tgaagaacat
    18181 gaagaatcag gtatttcagt atcaaaagaa attgtagaag aataagtaaa aatacaaaaa
    18241 aataactagt aattaaagac atgccacgct ccctattagc ttgacacaat gttgaaaaaa
    18301 ttataaaatt aagtgaggat aaaatatcta aatttaattt taattattag gaatattttt
    18361 taatcatagt gatgacattt tgggattatt aacgaaggag gtggatgtca tagatagtgt
    18421 agtaatgatt gtaataggtg cagctgttgg tattatagct ggatattttg ttagaaaaaa
    18481 tatatctgaa gcaaaaattg gacaagctga aaacttggcc aaagaaataa tagataaagc
    18541 acaccacgac tcagaaacag tacaaaaaga aaaattacta gaagctaaag aagagatcca
    18601 taagtggaga acagaagctg aaagagaaaa cagagaaaga agaacagaag tacaaaagta
    18661 tgaaaaaaga gtagtacaaa aagaagaagt cttagataga aaattacaaa atttagaatc
    18721 taaagaagta aacctaagtg aaaaattaaa ggtagtggaa aagaaagaag aagaagttga
    18781 agtaataaaa actcaacagt tagaaaaatt agaaagtata tcaggaatta cttctgataa
    18841 ggccaaagaa atcatcttaa ccaatgcgga gagagatgta agacgtgaaa tgtctataat
    18901 gataaaagag atagaaagtc aagctaaaga agaagctgat aagaaatcaa gagaaattat
    18961 aggatatgca attcaaaaat gtgcagcaga tcacgtagcc gaaactactg taacagtagt
    19021 aagcttgcct aatgatgaaa tgaaaggtag aataataggt agggaaggta gaaatataag
    19081 gactttagaa accttaacag gtatagacct tataatagat gacactccag aagccgtaat
    19141 tttatcagga tttgatccaa taagaagaga aattgcaaga attgctctag aaaaattaat
    19201 agcagatgga agaatacatc cagctagaat tgaagaaatg gttgaaaagg cgagaaaaga
    19261 agttgacaat attataaaag aatatggtga acaagctgca tttgaaacta gtgtacatgg
    19321 gattcatccg gaattaataa gattattagg tagacttaac tatagaacta gttatggaca
    19381 aaatgtactt aaacattcta tagaagttgc tcatatagct ggtataatgg ctgctgaaat
    19441 aggagcagat attagattgg ctaagagggc aggtttatta catgatatag gtaaggctgt
    19501 agaccatgaa atggaaggta cacatgttga aataggtatg gatttactta gacgttataa
    19561 agagtctaaa gaagttatac atgccatgag tactcatcat ggagattacg agcctcaaac
    19621 agtagaggct gtattagtta cagcagcaga tgcaatatca gctgctagac ctggtgcgag
    19681 aagagaaact ttagaagcat atataaagag acttgaaaaa ttagaagaaa tagctaattc
    19741 atatgaaggt gtagaaaaat catttgctat acaagctggt agagaaataa gaataatggt
    19801 aaaaccagaa gctataaatg atgaagaaat acatctattg gctagagata tgactaagaa
    19861 aatagaggat gaacttgaat atcctggaca aataaaagta agcataataa gagaaacaag
    19921 agctatagag tatgcgaagt aaaagaaata atatctaaat aataagaaaa tatttttaga
    19981 aatttaaatt tgccacaaga tatgataata tatcttgtgg cttttaaatt gtttaagttt
    20041 aattttatat aatgcaaaaa taatctaagt gctaaaagtg ctacttacaa aagattaata
    20101 aaataaagct ttatatatgt attatttata taattatcca agtttgtttg atataatgaa
    20161 gttgtaaaat caatacttta ctacaaaata aatagtaaat actacagtaa
//
LOCUS       DAEPID010000073        19553 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.073, whole genome shotgun sequence.
ACCESSION   DAEPID010000073 DAEPID010000000
VERSION     DAEPID010000073.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 19553)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 19553)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..19553
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.073"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            18..908
                     /locus_tag="KR257_002925"
     CDS             18..908
                     /locus_tag="KR257_002925"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888834.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="capsid protein"
                     /protein_id="HBH0031598.1"
                     /translation="MAALNYAKEYSNVLAQAYPYTLNFGDLYATPNNGRYRWTGSKTI
                     EIPTISTTGRVDSNRDTIAVAQRNYDNAWEPKVLTNQRKWSTLVHPADINQTNYVASI
                     GNITKVYNEEQKFPEMDAYCISKIYADWTALGNTADTTVLTTANVLEVFDKLMEKMTE
                     ARVPENGRILYVTPVVNTLIKNAKEIQRTVNIKDAGTSLNRQTTDIDTVKIIKVPSNL
                     MKTAYDFTTGWKVGAGAKQIFMSLVHPSAIITPVSYQFSKLDEPTAVTEGKFFYFEES
                     FEDVFILNKKADAIQFVVEA"
     gene            927..1160
                     /locus_tag="KR257_002926"
     CDS             927..1160
                     /locus_tag="KR257_002926"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888835.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0031599.1"
                     /translation="MPQVKKLNRILTIEECKIDDFLEMGYDLIDETGKAVKYGKSLSV
                     KDLIAENNILRSKVESLEEENKQLKEKNKLTKK"
     gene            1170..1571
                     /locus_tag="KR257_002927"
     CDS             1170..1571
                     /locus_tag="KR257_002927"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888836.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0031600.1"
                     /translation="MENNIIDEIEKRLESFGYILKDGDKWLIGFVREKIENIIKLDCN
                     IKTMPIELKEIEVDMIVGEFLFTKKNMGQLDIESINFEAVEKSISEGDTKVDFAIGSG
                     SQTPEQRFDSLIAYLTTYGKNKILTFRCLRW"
     gene            1565..1912
                     /locus_tag="KR257_002928"
     CDS             1565..1912
                     /locus_tag="KR257_002928"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015984843.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0031601.1"
                     /translation="MVSKTRKAIEMLYRDKCTIVEYQPIKDPVTKRTNNKEVIVLENQ
                     PCKLSYKNIVSATEGKVAKLEQTIKLFISPDIEIKAGSKLIINDKEYVRSGESAIYPN
                     HQEIILELFKDKA"
     gene            1912..2202
                     /locus_tag="KR257_002929"
     CDS             1912..2202
                     /locus_tag="KR257_002929"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893135.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HK97 gp10 family phage protein"
                     /protein_id="HBH0031602.1"
                     /translation="MARWGSVDFREFKRVCKKMEELTKIDLDKFCKDAARELAARLLG
                     KVIRRTPVDTGFLRQGWNGVAYARSLPVYKQGNNYIIEVVNPTEYALTQWGI"
     gene            2312..3118
                     /locus_tag="KR257_002930"
     CDS             2312..3118
                     /locus_tag="KR257_002930"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888838.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0031603.1"
                     /translation="MAKFLDITGKKFGRLRVIKFSKEIKSGKRNRKYWLCKCDCGNFK
                     EIRTDSLTSGLVQSCGCLKKEQDKLNLTDKYQFKKKYKVQNKRLYSIWKGIISRCTDK
                     NNKRYNRYGERNIIVCDEWFCYDNFANWALSNGYSEKLTIDRINNEGNYESSNCRWVD
                     IKTQCRNRSTNILVKHEEKEITLIELSEKTGISYSCLRSRYSKGLVGNNLIEKVKIIE
                     ESRAKLSIEDVKEIRKKYSDGYTIKQLSEIYPVTYSSISNIVHRRTWKNI"
     gene            3467..3904
                     /locus_tag="KR257_002931"
     CDS             3467..3904
                     /locus_tag="KR257_002931"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728452.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0031604.1"
                     /translation="MLNNIIDGISIKLDKTFGESYTIYSEDVEQGINEPCFFIVPLNP
                     SKVSYPSGRTLKKNSFDVHYFPKSNDKSFEIDEVAEMLLEELEYIEIDGDLVRGTNMN
                     FEIVDNVLHFFVDYNYFTIKNNDINKMDTVELFGGLKRGDNFE"
     gene            3897..4073
                     /locus_tag="KR257_002932"
     CDS             3897..4073
                     /locus_tag="KR257_002932"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728451.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0031605.1"
                     /translation="MSKTLSKGTDYKFTKEQIVNSKKYINRKDLLNAILKENELYSFS
                     EVEEIINSFMKGVS"
     gene            4075..5385
                     /locus_tag="KR257_002933"
     CDS             4075..5385
                     /locus_tag="KR257_002933"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728450.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phage tail sheath family protein"
                     /protein_id="HBH0031606.1"
                     /translation="MALGGGTFVTQNKILPGSYINFISAKRATSSLSDRGIVAIPLEL
                     DWGIDEDVFQVTSDDFEKYSVKYFGYDYTHEKLKGLRDLFKNIRLGYFYKLNKGVKAS
                     CTIATAKYSGIRGNDLKVTVTTNIDDNAKFDVVTLLDNKKVDTQIAKVITDLQDNDYI
                     TWKKDATLEASAGLVFTGGTNGEAVTGAEYQAFLDKIESYSFNALGCLATTTEIKSLF
                     VEFTKRMRDKVGAKFQTVLYKKSDADYEGVVSVENKIKDIGLVESSLIYWAAGVIAGC
                     DINKSNTNKKYDGEFDVDVNYTQIQLEEALKTGKFIFHKVGDEVHVLEDINTFVSFTD
                     DKNDDFSSNQSVRVLDQIANDIATLFNEKYLGKVPNDKAGRISFWNDVVKHHKELENI
                     RAIEDFKTDDVSVELGNDKKTVIVSDAVKVINAMSKLYMTVSVN"
     gene            5402..5872
                     /locus_tag="KR257_002934"
     CDS             5402..5872
                     /locus_tag="KR257_002934"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728449.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phage tail tube protein"
                     /protein_id="HBH0031607.1"
                     /translation="MAQTINAKDTVSAKKAECFITIEGKRYNFMQAIDLEAKMEKNKS
                     EVPILGRTTKGNKTTGSTNTGSATFHYNTSIFRELLYRYKETGEDIYFDIQVTNEDPT
                     SAVGRQTVVLKDCNMDSGIITKFDADGEYLDEDMDFTFEDWELVEKFNLLAGME"
     gene            5944..6384
                     /locus_tag="KR257_002935"
     CDS             5944..6384
                     /locus_tag="KR257_002935"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009894348.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phage portal protein"
                     /protein_id="HBH0031608.1"
                     /translation="MSNLSAFLSQNAIKVDNVKYVASNRFLDKEGKPVEWELKVLSSE
                     EDEALRRKCTKRVKVIGNNGKHTGQYTSEIDYNSYVAELCVASTVFPDLKDAELQNSY
                     GVMGEAQLLKTMLTAGEYVNYTVKVNEVNGFDTSFEDKVEEAKN"
     gene            6725..6886
                     /locus_tag="KR257_002936"
     CDS             6725..6886
                     /locus_tag="KR257_002936"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429855.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0031609.1"
                     /translation="MNNFLLNVIAGVIASLIFCLICKVFLKVKSHSTRGKSKSGWEFD
                     FKIKFHKFK"
     repeat_region   7624..8047
                     /inference="COORDINATES: alignment:crt:1.2"
                     /inference="COORDINATES: alignment:pilercr:v1.02"
                     /rpt_family="CRISPR"
                     /rpt_type=direct
                     /rpt_unit_range=7624..7652
                     /rpt_unit_seq="gttttagattaactatatggaatgtaaat"
     gene            8211..8384
                     /locus_tag="KR257_002937"
     CDS             8211..8384
                     /locus_tag="KR257_002937"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003433557.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CopG family transcriptional regulator"
                     /protein_id="HBH0031610.1"
                     /translation="MSSKMGRPKVDNPKNIDVKVRFDENTHKKLLDYCEKENLTRTEA
                     IRKGVDLLLEEDK"
     gene            8508..9335
                     /locus_tag="KR257_002938"
     CDS             8508..9335
                     /locus_tag="KR257_002938"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018112721.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="toxin Bro"
                     /protein_id="HBH0031611.1"
                     /translation="MNNELMNFENNELGIKIRTIKYEDGSIGINAEDTAVGFGWCQTQ
                     NKNGKQYVSIRWETINKYCKEFGFLNLLGKDEYIPESLFYLLGMKAKNEIAVKFQTWL
                     AVDVLPSIRQTGAYITNNANPEKLREKASEIEKLQLAYNSTSMLKELLDGAGFDNKSK
                     LLTAKTLYKKAGIDLPIEIEEEESFFDTKQIASKLKIYSKSNKPAQLAVCEIIKKIDL
                     EENEVKGVWETNGSWTGTVNKYTKSVIDKVRNWIEENNRPAKIAGEKKNYHVVYKIE"
     gene            9398..9574
                     /locus_tag="KR257_002939"
     CDS             9398..9574
                     /locus_tag="KR257_002939"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003433561.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0031612.1"
                     /translation="MCENLLNEYNLKTDEDVEYFVKFATLLYKLKQDNEEKFQEYAEI
                     LRGILREQQERENK"
     gene            complement(9987..10190)
                     /locus_tag="KR257_002940"
     CDS             complement(9987..10190)
                     /locus_tag="KR257_002940"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008982964.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HBH0031613.1"
                     /translation="MYFNIDKLLESKGRTRYWLAKEVGIAYPNMMKLANNETSSIKLD
                     LFEKLCLVLECTPNELVTLSSKE"
     gene            10434..10820
                     /locus_tag="KR257_002941"
                     /pseudo
     CDS             10434..10820
                     /locus_tag="KR257_002941"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013726857.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="ORF6N domain-containing protein"
     gene            10884..11237
                     /locus_tag="KR257_002942"
     CDS             10884..11237
                     /locus_tag="KR257_002942"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861515.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0031614.1"
                     /translation="MKLLVTKTFFERAGIELPLEVEEKEHFYDTKQIAKKLGLYTMSN
                     KPAFMAVKQIIRKLDIKEDEMKTVLETNGNWTGTVTKYSNKVTEKVKVWLKENNNPIS
                     IKGDKKNYYILYKNN"
     repeat_region   11669..12620
                     /inference="COORDINATES: alignment:crt:1.2"
                     /inference="COORDINATES: alignment:pilercr:v1.02"
                     /rpt_family="CRISPR"
                     /rpt_type=direct
                     /rpt_unit_range=11669..11697
                     /rpt_unit_seq="gttttatattaactatgtggtatgtaaat"
     gene            12750..13265
                     /locus_tag="KR257_002943"
     CDS             12750..13265
                     /locus_tag="KR257_002943"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009901472.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="zinc ribbon domain-containing protein"
                     /protein_id="HBH0031615.1"
                     /translation="MFCSNCGYEITGAGKFCSNCGTATLADKVNNDDLFINVHGKELN
                     LTNIYKETKGDKILAIDIAMKLLGLDIKECKNIIYPAFKELSEKINIEEEKEILREDE
                     YKQTNVLEDDVARCPRCGSVSLSAHKKGFGIGKAVAGATIAGGIGLVAGNLGAKKVRV
                     TCLSCGKQFWA"
     gene            13330..15723
                     /locus_tag="KR257_002944"
     CDS             13330..15723
                     /locus_tag="KR257_002944"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893138.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tape measure protein"
                     /protein_id="HBH0031616.1"
                     /translation="MATIQTSIKIFDGMTPAFRNMTNSINTTINSLERLQGRLNNPLN
                     AGNIQASQQSLNNIESILTRIEQKIGRNTNEQENFNNKIRQGSEAGSLLVSKLKSIAG
                     IYIGIKGIDSITKVADTIASTKARLNLMNDGLQTTDQLNKMIYLSAQSARASYADTAA
                     QIAKLGILAGDAFGSSAEVIKFTELMNKAFVIGGTSANEASAAMYQLTQAMGAGKLQG
                     DEFRSIMENAPLLATKIADAMGKTKDQLKELSSSGAITADVIRNALFKASDEIEKKFA
                     SMAITFSQALTMMKNDAYMIFSETLSKISGALQSVRFSEIVVSIRNVMIAISSNIYDT
                     LNIIKNILNSDFFSDFVSNVTLGAILIINGLGWVTNATLNVANVFAQNWSIIAPIIYG
                     VIAAIAIYKGVLLASTIATTVASFVNSLYAVAAYKSCAALAAQEFAIFGKISAQTMEA
                     LVTAQATAAQWGFNAALLSCPIFWIIAGIIAFVVVVFVAVAAVNKFSGTSLTVLGAIV
                     GAVFAAVAFIQNIMIWLFNRCVDVNEGIANGWNQCVYLMKQAIAKGVIFIIEKMASLN
                     DAVNNAGNALGKAFIDGANIAIRGVNKLIDLINKIPGINIGKVGEATFTPVKADNSYI
                     KQQIDSLNKWVGDAPEKIKLDRMGYKDIGAEFQKGNALGTKWQNAITDKFKDTFDINK
                     MLEDAKKKLGLDDLWNKQNPLNNLGGFGGDLGKNVKDTAGNTAKMAKTMDKSQEDLKY
                     LRDIAEQETINRFTGVNIKIDMNNTNNISKDTDVDGIVNVLTEKLNDAMIVSAEGIV"
     gene            15739..16428
                     /locus_tag="KR257_002945"
     CDS             15739..16428
                     /locus_tag="KR257_002945"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009901468.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LysM peptidoglycan-binding domain-containing
                     protein"
                     /protein_id="HBH0031617.1"
                     /translation="MAYDFYLDGVQLPIPPPKLEIKVTNKNKIVDLINTGEVNILKKE
                     GLSEISFEAEFTHNKLPFYRGAFRDVQFFLSKLELLKTDCKPFQFIVSRELGNKVLFN
                     TNIKVSLEEYAISEDAENGSDTKVAIKLKQYRDYSTKKLVLAPPKNETGRPNVKIEPK
                     RVDSVNATNTKTYTVKAGDSLWSICQKQLGNGSLYKKVYELNKTMMDKANKGKKVPKY
                     TIYKGQVLRLV"
     gene            16421..18313
                     /locus_tag="KR257_002946"
     CDS             16421..18313
                     /locus_tag="KR257_002946"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893140.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="C40 family peptidase"
                     /protein_id="HBH0031618.1"
                     /translation="MSDDLVLANDRDIRLVIAHWEDFYEPAVIDGITWEIERRGSPSK
                     LEFTIAMDDILEFCEGNSVRIYYKGIGIFYGYIFQKKRDKENHIKIVAYDQLRYFKNK
                     DTYVYSNKTASELVKMLAKDFNLKYNVIEDTKYKISRVEENKTLFDMVLTALDDTLRE
                     KKEMYVLYDDFGRITLKNVASMKLDTVMNNDVIEDFDYNSSIDSDTYTKIKLVRDNEE
                     TGKRDVYIAQDSTHMRSWGILQMFDTVDKNMSEAEIKQKCDILLKLYNKKTKSLSLKN
                     VLGDIRVRAGCLVPVFLNLGDIKLQNYMLVEKVKHTFENNSHFMDLTLVDGDEFASYS
                     SSSYSSGNTNNKDEKKNGPAQSITKKNTGKKVPAIFTAYYPGNNAMEGGKTDCNGKPL
                     DVKSRTVAGPMNREGVKKTWYTDDFLKKHPVFEYGDKVKIILPGTAYDNKVYTVKDNG
                     GRIYVETNGTYHIDVLLANASECKKFGRKNGYIIIGGDEEQTYQVEGNNQSSTNNNSK
                     EDKLISIAKSKLGCNYVYGAEGPNNFDCSGFTQWCYKQIGIKIPRTASAQSKAGKAVD
                     LKDRSKWKAGDLLCRIGGGSSNHVVMYIGNNQIIHSPQTGDVVKIESVNSYRKGKAYT
                     HVRRFI"
     gene            18327..18587
                     /locus_tag="KR257_002947"
     CDS             18327..18587
                     /locus_tag="KR257_002947"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009901352.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF2577 domain-containing protein"
                     /protein_id="HBH0031619.1"
                     /translation="MSQDLLQIIKKAAMDAVETSNPMRVVFGTIESISPLRVKIEQKL
                     SIGEIFLIQTDTFKRYTDKKIGDKLVLIRMQGGQQYLILDRM"
     gene            18592..19011
                     /locus_tag="KR257_002948"
     CDS             18592..19011
                     /locus_tag="KR257_002948"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009901339.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF2634 domain-containing protein"
                     /protein_id="HBH0031620.1"
                     /translation="MLPSDNLDYDIEDVSIINFDVRQEPSKTFKLHIEKSKIDGICDD
                     VEALKQTIFLILNTERYQHLIYSWNYGVELNDLIGEPISFVIPELERRIKEALIQDDR
                     VENVDNFEFENIKGKVQCKFSVHTKYGNIKAEKVVSV"
     gene            19024..>19553
                     /locus_tag="KR257_002949"
     CDS             19024..>19553
                     /locus_tag="KR257_002949"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015984854.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="baseplate J/gp47 family protein"
                     /protein_id="HBH0031621.1"
                     /translation="MTFENIIKRMLDSVPNTLDKREGSIIYNALAPVAVELTETYIAM
                     DELLDQTFVDTASYYYLEKRCKERGITPLPATNTIAKGVFNIDIPLDSRFNLGEYNYI
                     AIERISEKTYKMKCETAGPIFELGKLIPIEYIDGLETAELTEILINGEDEESEDSLRQ
                     RYYDSLNSQSFGGNIQ"
BASE COUNT         7784 a         2073 c         3707 g         5989 t
ORIGIN      
        1 aaataggagg aaataaaatg gcagcactaa attatgcaaa agaatattca aatgttttag
       61 cacaagcata tccttatact ttaaacttcg gggatttgta tgcaacacca aataatggaa
      121 gatatagatg gactggttct aaaacaatag aaataccaac tatatctaca actggaagag
      181 tagattcaaa cagagataca atagcagtag ctcaaagaaa ctatgataat gcttgggaac
      241 ctaaggtatt aactaatcaa aggaaatggt ctacattggt tcatccagca gatataaacc
      301 aaactaatta tgtggcttca ataggcaata taacaaaagt atataatgag gaacaaaagt
      361 ttccagagat ggatgcttac tgtatatcta aaatatatgc tgattggacc gcattaggta
      421 acacagcaga tacaactgtt cttacaacag caaacgtatt agaagtattt gataagttaa
      481 tggaaaaaat gacagaagct agagtacctg aaaatggaag aatattgtat gttactccag
      541 tagtaaatac acttatcaaa aatgcaaaag agatacaaag aacagtaaat ataaaggatg
      601 caggaacttc tcttaatcgt caaacaactg atattgacac agttaaaata attaaagtac
      661 catctaatct aatgaaaact gcatatgatt ttacaactgg atggaaagta ggagcaggag
      721 ctaaacaaat ctttatgtcc ttagttcacc caagtgcaat aattacacct gtttcttatc
      781 agttctctaa gttagacgaa ccaacagcag ttacagaggg aaaattcttc tactttgaag
      841 aaagttttga ggatgtattt atattaaata aaaaagctga tgcaatacaa tttgttgttg
      901 aagcatagaa aaaggagtga tatatagtgc cacaagtaaa aaaactaaat agaatactaa
      961 ccatagaaga atgtaaaata gatgatttct tagagatggg atatgatttg atagatgaaa
     1021 ctggtaaggc agtaaagtat ggcaagtcat taagtgtaaa agatttaata gctgaaaata
     1081 atattttaag gtcaaaagtt gagtctttag aagaagaaaa taagcagctt aaagagaaaa
     1141 ataaacttac taaaaagtag gtgaaaatta tggaaaataa tataattgat gaaatagaaa
     1201 aaagacttga aagttttgga tatatattaa aagatggaga taagtggtta ataggttttg
     1261 taagagaaaa aatagaaaat attattaaac tagattgtaa tataaaaact atgccaattg
     1321 aattgaaaga aattgaagtt gatatgatag ttggagagtt cttatttacc aagaaaaata
     1381 tgggtcaatt agatatagaa agcattaact ttgaagctgt agaaaagtct atatcagaag
     1441 gtgatacaaa ggtagatttt gctataggaa gtggttctca aacaccagaa caacgctttg
     1501 atagcttaat agcttatctt actacttatg gcaagaataa gatattaacc tttaggtgct
     1561 taagatggta agtaaaacta gaaaagcaat agaaatgtta tatagagata aatgtactat
     1621 agttgagtat cagccaatta aagaccctgt aacaaaacga actaacaata aagaagtgat
     1681 tgtattagaa aatcaaccat gtaaactttc atataaaaat atagtttctg ctacagaagg
     1741 gaaagtagct aagctagagc aaactattaa actctttata tctccagata tagaaattaa
     1801 agcaggttca aaacttatta taaatgataa agagtatgta agaagtggag aatcagctat
     1861 atatccaaat catcaagaaa taatacttga gttatttaag gataaagcat aatggctaga
     1921 tggggcagtg ttgattttag agagtttaaa agagtttgta aaaagatgga ggagcttaca
     1981 aagattgatt tagataagtt ttgcaaggat gcagcaagag aattagcagc acgattactt
     2041 gggaaagtaa ttagaagaac accagttgat acaggattct tacgacaagg atggaatgga
     2101 gtggcttatg ctaggtcgct tcctgtgtat aaacaaggaa ataattatat tatagaggtt
     2161 gttaatccga ctgaatatgc cttaacacaa tggggcatat aaaacccagc aaaatcggta
     2221 aacgctaagt gtaatagtgt tacattataa agtaggtaga atatggacat agaataactc
     2281 ttgatttata atgtataaaa gaggtgattt tatggcaaaa tttttagata ttacaggaaa
     2341 aaaatttgga aggctaagag tcattaaatt ttctaaagag ataaaaagtg gtaaaagaaa
     2401 tagaaaatat tggttatgta agtgtgattg tggaaatttc aaagaaataa gaactgactc
     2461 tttaactagt ggcttagtac aatcttgtgg atgtttaaaa aaagaacaag ataaattaaa
     2521 tttaacagac aaataccaat ttaaaaagaa atataaggtt caaaataaaa gactttacag
     2581 tatatggaag ggtataatat ctagatgtac agataaaaat aataaaagat acaatagata
     2641 tggtgaaagg aatataattg tgtgtgatga atggttttgc tatgataatt ttgcaaattg
     2701 ggcattgagt aatggatatt cagagaaact tacaattgat agaataaata atgaaggaaa
     2761 ttatgaatca agcaattgta gatgggtgga tataaagaca caatgtagaa ataggtcaac
     2821 aaatatatta gtaaagcatg aagaaaaaga aattacattg atagagcttt ctgaaaaaac
     2881 aggtatttca tattcttgct taagaagtag atattctaag ggattagtag gaaataatct
     2941 tatagaaaaa gttaagatta ttgaagaaag cagagctaag ttatctattg aggatgtaaa
     3001 agaaattaga aaaaagtatt ctgatggata tacaataaaa caactaagtg aaatatatcc
     3061 tgtaacatat tcatctatat caaatatagt ccatagaaga acatggaaaa atatttaatt
     3121 aattatatat gccaataccg aggaaaacct atagattgcg aataggctat aggtttccgt
     3181 agagcgtaga gagtgaataa atataatctc tccaagagtg ctgggcaact aaataaagtt
     3241 tattttgttg atgatgtacg ccgaacttat aggaaactat aagagctaga ggataaaaag
     3301 cctttaggat aacaaaatgc atatgttgaa tatggccata gaactaaaga tggaaaaggt
     3361 tgggttaaag gacaacattt cttaacaatt tcagagatgg aactacaaag ccaagttgat
     3421 aagattatag agaaaaaact attaatattg cttaaaggag tatttgatgc ttaataatat
     3481 aattgatgga atatctatta aattagataa aacatttgga gagagttata caatttatag
     3541 tgaagatgtg gagcaaggta taaatgaacc ttgttttttt attgttcctt taaatccaag
     3601 caaagtatcc tatccaagtg gcaggacatt aaaaaagaac tcttttgatg tacattattt
     3661 tccaaaaagt aatgataaat catttgaaat agatgaggta gctgagatgc tactggagga
     3721 attagagtat atagaaattg atggagattt agtcagaggt acaaatatga actttgaaat
     3781 tgtagataat gtacttcatt tctttgttga ttataactac tttactataa aaaataatga
     3841 tatcaataag atggatacag tagagttatt cggtggtttg aagagaggtg ataattttga
     3901 gtaagacatt aagtaaagga accgattaca agtttactaa ggagcagata gttaattcta
     3961 agaagtatat aaatagaaaa gacttattaa atgcaatttt aaaagaaaat gagttatatt
     4021 ccttctcaga ggtagaggaa ataataaata gctttatgaa aggagtgagt taatttggcg
     4081 ttaggtggag gaacatttgt aacacagaat aaaatattac caggtagcta tataaatttt
     4141 atctcagcta agagggcaac cagttcatta tcggatagag gtattgttgc aataccttta
     4201 gagttagatt ggggcataga tgaagacgta tttcaagtaa ccagtgatga ttttgagaag
     4261 tattcagtga agtattttgg atatgattat actcatgaga agctgaaagg tttgagagat
     4321 ttattcaaaa atataaggtt gggatatttt tataaattaa ataaaggcgt taaagccagt
     4381 tgtactatag ccacagcaaa atatagtggt atcagaggaa atgacttaaa agtaacagtt
     4441 acaacaaata tagatgataa tgctaagttt gatgttgtaa cacttttaga taataagaag
     4501 gtagatactc aaatagcaaa ggttattaca gacttacaag acaatgacta tatcacttgg
     4561 aagaaggatg caacactaga agcaagtgca ggacttgtat ttactggtgg aactaatggc
     4621 gaagctgtga caggagcaga gtaccaagct ttcttggata aaatagaaag ctatagcttt
     4681 aatgctttag gatgtttggc tacaacaaca gaaattaaaa gtttatttgt agaatttaca
     4741 aagagaatga gagataaggt aggagctaag tttcaaacag tactatataa gaaaagtgat
     4801 gcagattatg aaggtgtagt gtctgtagaa aataagatta aagatattgg attagtagaa
     4861 tctagtttaa tttattgggc ggctggagtt atagcaggat gcgatataaa taaatctaat
     4921 actaataaaa agtatgatgg tgagtttgat gttgatgtta attatacaca aatacaactt
     4981 gaagaagctt taaaaactgg taaatttata ttccacaagg tgggagatga agttcatgtg
     5041 ttagaggata taaatacttt tgtatcattt acagatgata aaaatgacga tttttcaagt
     5101 aaccaaagtg ttagagtact tgaccaaatt gctaatgata ttgcaacttt atttaatgaa
     5161 aagtatttag gtaaagttcc gaatgataag gcaggaagaa taagtttctg gaatgatgtt
     5221 gttaaacacc ataaagaatt agagaatata agggcaatag aagattttaa aactgatgat
     5281 gttagtgtag agcttggaaa tgataagaaa actgtcatag tatctgatgc tgttaaggta
     5341 ataaatgcta tgagtaagct ttatatgact gtttcagtta attagagagg agagtgataa
     5401 tatggctcaa acaataaatg ctaaagatac agttagtgca aagaaagctg aatgttttat
     5461 aactatagaa ggtaaaagat ataattttat gcaagctata gatttagagg ctaaaatgga
     5521 aaaaaataaa agtgaagttc caattctagg aagaacaaca aagggaaata aaacaactgg
     5581 gagtacaaat actggaagtg caacatttca ttataatact tctattttta gagaattact
     5641 ttacagatat aaagaaactg gtgaggatat ttattttgac atacaagtta caaatgaaga
     5701 ccctacatct gctgtaggaa gacagacagt agtacttaaa gattgtaata tggacagtgg
     5761 aataattact aaatttgatg ctgatggtga gtatttagat gaagatatgg atttcacttt
     5821 tgaggattgg gaattagtag aaaaatttaa tttattggca ggaatggagt aaaatacaca
     5881 tttataaatt atatatgtgt attttttata tgaaaaatta aaataaaagg agattagaat
     5941 aatatgagta atttaagtgc ttttttaagt caaaatgcaa taaaggttga taatgtaaaa
     6001 tatgtagcga gtaacagatt tttagataaa gaagggaaac cagttgaatg ggaattaaaa
     6061 gttttatcat ctgaagaaga cgaagcacta agaagaaagt gtactaaaag agtaaaagtg
     6121 attggtaaca atggtaagca tactggacaa tatacaagtg aaattgacta caatagttat
     6181 gtagctgaat tatgtgtagc atctacagta tttccagatt taaaggatgc cgaactccaa
     6241 aatagttatg gagtaatggg agaagctcag ttattaaaga caatgcttac agcaggtgag
     6301 tatgtcaatt atacagtaaa agtgaatgaa gtcaatggat ttgatacatc ttttgaggat
     6361 aaagtagaag aagcaaaaaa ctaatcagag gtggcgattt tgatgctagc atcactcatt
     6421 attgtattca aaaattaaag tggaagccaa gtgaatatat gaatttagaa gttaatgaga
     6481 gagcgttagc agccgcctca atacttataa agatagaaga tgaagaggaa gcaatgaaag
     6541 aagctgaaag agagagaaag aggggacgaa gaagatagca aaataaaaaa ataaatatag
     6601 aataggtaaa atatgtaata attatatgtt ataatatttt tagcaagaag atgtaatcta
     6661 caatttatag agtggagttc atactgggat aaaacctact tcctaatgaa aggaggtggg
     6721 aagtatgaat aactttttac ttaatgtaat agctggcgtt attgctagtt taatattttg
     6781 cttaatttgt aaagtatttc taaaagtaaa aagccactca actcgtggca agagtaaaag
     6841 tggctgggaa tttgatttta aaatcaagtt ccataagttc aaatagattc atttaattat
     6901 gaacttcact ctaccgcaaa atagattgta gttcttcttg cttttattat accacaaatt
     6961 agaaaaaata ttgtttatat aaaataaaaa ataaaaattt ttattaaaaa attgaaaact
     7021 tgattataaa gcaattaatt tataaaatat atataaataa gtaggtattt atttacttga
     7081 atttcattgt ttatataaaa aaaatggaaa aatatgtaat aattatatgt tataataatt
     7141 gtagcaagga taataatcga aagtgcgaag ggtgattatt ttcatattaa acgccaaatt
     7201 ccaaataagg aaggaggtga aattatatga taggtttttt attaagcata ctagctggtg
     7261 ttatatcagc ttatatttat gacaaaataa aaaatcaccc agacgccaat aagggtgatt
     7321 taaaaaaata attctttaaa tcaattttga tggaaatagc tactcttgta taaagtaaat
     7381 tatttccttg cttttattat accacaaatt ggtacagata ttcaaaaata atatttttat
     7441 gatataataa aaatgtagag attttgcagt gagcaatatt tgcgataaat tgaagtttaa
     7501 caattggaat acaaggtatt gagggtgtgt gataaatgtt atcaattgca ctactcatgg
     7561 ttcactgcaa atttgagaga gatgcgtatg tgtaggtatt ggaaatgcca agtttatttt
     7621 ggggttttag attaactata tggaatgtaa attaaccttt ttattgttgt tgttattctt
     7681 attgttattc gttttagatt aactatatgg aatgtaaatg ttgtaagaag tatcattcta
     7741 ttttttaatc tttctgtttt agattaacta tatggaatgt aaatagtaca tataatgagt
     7801 ctttaacatc agttatgaaa ggttttagat taactatatg gaatgtaaat gattgtactt
     7861 tagcgtctgc actagctttg tctatcgttt tagattaact atatggaatg taaattattt
     7921 tacagatgaa caattacagt tacttcttga atgttttata ttaactaagt ggtatgtaaa
     7981 taatggaagc aagataattt ttaaaggtat ggataattgt tttatattaa ctatgtggat
     8041 tcaaaattaa atagaaaaaa gaaagcactt acttaaatag taggtgcttt tgttttgctc
     8101 aaaattggtc ggttgagtaa aataattaga aaaaattggg ataagttatt gactttttgg
     8161 aacacaaata atataattat attatggaac acaaaaagtg aggtgaaaca atgagttcta
     8221 aaatgggaag accaaaagtt gataatccta aaaatattga tgtcaaagta agatttgatg
     8281 aaaatactca taaaaaatta ttagattatt gtgagaaaga aaatcttact agaacagaag
     8341 caataagaaa aggagtagac ttacttttgg aggaagataa gtaaaaaagt agcccaacgc
     8401 cgaccaaagc atactggact acttaaccta gagttatctc tatatgaaat attctatcat
     8461 gtaaagataa ctctttcaag ataataaatc gaaagggtga tttttgtatg aataatgaac
     8521 tgatgaattt tgaaaataat gaattaggaa taaaaataag aactattaaa tatgaagatg
     8581 gaagtatagg aattaatgca gaggatacag ctgtagggtt tggatggtgt cagacacaga
     8641 ataaaaatgg taagcaatat gtatcaatta gatgggaaac tattaataaa tactgtaaag
     8701 aatttggttt cctcaacttg ttggggaaag atgagtatat acctgaatca ttattttatc
     8761 ttttaggtat gaaagctaaa aatgaaatag cagtaaaatt tcaaacatgg ttagcagtag
     8821 atgtactacc atcaataaga caaactggtg catacataac taacaatgct aatcccgaaa
     8881 aactaagaga aaaagcaagt gagattgaaa agttacaatt agcctataac agcacatcta
     8941 tgttaaaaga attgctagat ggtgcaggat ttgacaataa atccaaacta ttaacagcta
     9001 aaacattata taaaaaggca ggcattgatt tacctataga aattgaagaa gaggaatctt
     9061 tctttgacac aaaacaaata gcatctaaac tgaaaatata ttctaagagt aataaaccag
     9121 cacagttggc tgtttgtgaa attattaaaa agattgattt agaagaaaac gaagtcaaag
     9181 gcgtttggga aactaatggt tcttggactg gtactgtaaa taaatataca aagagtgtaa
     9241 tagataaggt tagaaattgg atagaggaaa ataatagacc tgctaagatt gcaggtgaaa
     9301 agaagaatta tcatgtggtt tataagattg agtaaattta tcagttgtat taaataattt
     9361 agtttagttt attttagttt tgagggggat taatacaatg tgtgagaatt tacttaatga
     9421 atataattta aaaactgatg aagatgtaga atactttgta aagtttgcta cattattata
     9481 taaattaaaa caggacaatg aagaaaaatt tcaagagtat gcagagatat tgagaggtat
     9541 tcttagggaa caacaagaga gagaaaataa gtaaaataat atagataaag cacttgaata
     9601 ttacatagtt tcaagtgctt tgtttggtat aaaatggtat aatagagata agagttatat
     9661 taactatgtg gtatgtaaag aatgtataag gcatcttctc aaattctgcg ttggtcattt
     9721 tatattaact atgtggtatg taaagtgcgt taactgcaat aatgctgaac tcatttcttg
     9781 attttatatt aactaagtgg tatgtaaatg ttaattcctt caaccttcta atagaagatg
     9841 cttttaggtt tatattaact aagtggtatg taaatgtttc aacatttgac atgtgctgtg
     9901 gagtaatgtt tatgttttat attaactatg tggattcaaa attaaataga aaaaagaagc
     9961 acttacttaa atagtaggtg cttttgttat tctttgctag ataaagtaac aagttcatta
    10021 ggtgtacatt caagaacaag acaaagcttt tcgaataaat ctaattttat agaacttgtt
    10081 tcattgttag ctaatttcat catgttagga taagctatac ctacttcttt agctaaccaa
    10141 tatctagttc gacctttgga ttcaagtaat ttatcaatgt taaaatacat tttttcacct
    10201 cttaagtata ttatacaaca attatataat gtttgcaata tataatatgc aaacaatata
    10261 attatataat gttgacatta tataatgtgt gcgatataat atacttaagg aataaaaaat
    10321 aagagccact cgcccctacc aagtttgagt aactcttatt gacatatact acatatacat
    10381 taattatagt atatgtcatt ccttaaaaaa aatcaattaa ggagtgtgtt tttatgaaca
    10441 atttagtact aattaacaat caagaagtgc aagttaagga atttaataat caaagagtag
    10501 ttacatttaa agaaattgac agagtacatg aaagagtaga aggaacagca ggtagaaatt
    10561 ttagagaaaa taagaagcac tttataaaaa atgaggacta tttttattta gaaggaaaag
    10621 aattatcaac aattaaacag acaacgaatt tcgttggcag taatgcaaga gaattaatct
    10681 tattaactga aacaggttat ctaatgttag taaaatcttt tacagatgat ttagcttgga
    10741 aagtacaaag acaattggta aatagttatt ttagagttaa agaagaaaag aaagaaatga
    10801 aagcattaga aaaattagaa acagttaatg agtcaattag gttaataact ccaatttttg
    10861 atgatttaaa cattgataaa agtatgaaac ttcttgtaac taagactttt tttgaaagag
    10921 caggtattga attgcctctt gaagttgaag aaaaagaaca tttttatgat acaaagcaga
    10981 ttgcaaaaaa attaggactt tacacaatgt ctaataaacc agcatttatg gcagttaagc
    11041 aaattataag aaagcttgat attaaagaag atgaaatgaa aacagtatta gaaacgaatg
    11101 gcaattggac tggtactgta acaaaatatt ctaataaggt tacagaaaag gtcaaagtgt
    11161 ggttgaaaga aaataataat cctatctcaa tcaaaggaga caagaaaaac tactatatat
    11221 tgtataaaaa taattagatt ttagtttttg ggggggtaat acaatgtatg agaatttact
    11281 tgatagtata gatattgaaa agagaaaaga agaatttaga attaaacttt tgaaaataag
    11341 agaaacagat atagatatat atatataata agatagaaag aatagtatat aaactttctg
    11401 agaaaaaatt agagaaaaat aattaaataa atagataaag cacttggata ttatgttgtt
    11461 tcaagtgctt tatttggtat aaaatggtat aataaaaata taggaatttt gcagtgttcg
    11521 atttttctac ttaagtatag tttaacaatt ggaatacaag gcattgagaa ggtttgataa
    11581 gtgttatcaa ttgcactatt acccgctcac tgcaaatttg agaaagttat atgtgtgtaa
    11641 gtcttggaaa tacacaattt attttggggt tttatattaa ctatgtggta tgtaaatctt
    11701 tttaaaaaag cacgtcaatt acaatactaa aattgtttta tattaactat gtggtatgta
    11761 aatttgaaaa ctgcatgttc tttaacaaaa gcatctaatt gttttatatt aactatgtgg
    11821 tatgtaaatg tattactccc aattatgaac ataggatata gtctttgttt tatattaact
    11881 atgtggtatg taaattatag tttgccatat gttcctggtt cgtatgattg gggttttata
    11941 ttaactatgt ggtatgtaaa taaatttaat attactggaa aaggagaaat ggatatcggt
    12001 tttatattaa ctatgtggta tgtaaatttt gttataagaa tatcgccacc ttccttttct
    12061 ggtgttttat attaactatg tggtatgtaa atttttctgc atcttctact atgttatatt
    12121 cttctaatgg ttttatatta actatgtggt atgtaaatgc acatttaact tcaagtctta
    12181 gagtattatc tgcaagtttt atattaacta tgtggtatgt aaatttcgtt caacttttat
    12241 cttagcttct cctgctactt gttttatatt aactatgtgg tatgtaaatg tactagaaaa
    12301 tgcactacct gcattcattc ctatacggtt ttatattaac tatgtggtat gtaaatgtgc
    12361 tatttccaac ttttttttca agttctgaat actgttttat attaactatg tggtatgtaa
    12421 attagttagt cccatatcgt tatggtactg cattaacgcg ttttatatta actaagtggt
    12481 atgtaaatag tgtaaaaggc attttttcaa attgtgcatt ggtttggttt atattaacta
    12541 agtggtatgt aaaggctaat gtttgagtat ttaaaagcat ctgagcaaac aattttatat
    12601 taactatgtg gacttaaaat taaaaataat tcaaaaacac ttacaaatga gtaagtgttt
    12661 ttttaatgaa aggaggtgat aataatgtaa aaattttacg tatatagtat aatagtgcta
    12721 taaaataagt attatgtgag gtgattgttg tgttttgttc aaattgtggt tatgagataa
    12781 ctggtgcagg caaattttgc tcaaattgcg gaacagctac attagcagat aaagttaaca
    12841 atgatgattt atttataaat gttcatggaa aagaattaaa tctgactaat atttataaag
    12901 aaactaaagg agataaaatc ttagcaattg atattgcaat gaagttacta gggctggaca
    12961 taaaagagtg taaaaatatt atatatccag cttttaaaga attaagtgaa aaaataaata
    13021 tcgaagagga aaaagagata ttgagggaag atgagtataa acaaactaat gtacttgaag
    13081 atgatgttgc tcgttgccct aggtgtggct ctgtttcatt gtctgctcat aagaaaggtt
    13141 ttggcatagg aaaagctgta gcaggggcta ctatagcagg aggcattggt ttagtagctg
    13201 gaaatttagg agcaaagaaa gttagagtta catgtttgag ctgtggtaaa cagttttggg
    13261 cataaataat aaacacttac taatgtaggt gtttttttat atggaaattt atgaaaggag
    13321 agtgaggaaa tggctacaat acaaacttca ataaagattt tcgacggaat gacaccagca
    13381 tttcgtaata tgactaattc tattaataca acaattaata gtttagagag attgcaaggc
    13441 agattgaata atccactcaa tgcaggtaat atacaagctt ctcaacaaag tttgaataac
    13501 atagaaagta ttctcacaag gatagaacag aaaattggaa gaaatacaaa tgaacaggaa
    13561 aactttaata ataaaataag acaaggtagt gaagcaggtt ctctattagt gtctaaatta
    13621 aaaagtattg ctgggatata cattggaata aaaggaatag atagtattac aaaagtagca
    13681 gatacaattg caagtacaaa agcacgttta aatctaatga atgatggctt acagacaaca
    13741 gaccagctta ataaaatgat ttatttgtca gcccaaagtg caagagctag ttatgcagat
    13801 acagcagcac agattgctaa acttggaata cttgcaggag atgcttttgg aagttcagca
    13861 gaggtgataa agtttacaga acttatgaat aaagcttttg taattggagg aacatcagca
    13921 aatgaagcta gtgcagcaat gtatcaatta acacaagcca tgggtgcagg aaaacttcaa
    13981 ggtgatgagt tccgttccat aatggaaaat gcacctttat tagccactaa aatagctgat
    14041 gcaatgggaa aaactaaaga ccaattgaag gaattatcaa gtagcggagc aataacagca
    14101 gatgttataa gaaatgcact gtttaaagct tctgatgaga tagaaaagaa atttgcaagt
    14161 atggcaatca ctttttctca agctctcaca atgatgaaaa atgatgctta tatgatattt
    14221 tctgagactc tcagtaagat aagtggagct ttgcaaagtg tacgttttag tgagattgtt
    14281 gtatctatcc ggaatgttat gattgcaata tcttcaaaca tttatgatac attaaatatt
    14341 ataaaaaata tattaaatag tgattttttt tcagattttg ttagcaatgt tacattagga
    14401 gctatactaa ttatcaatgg actgggatgg gttactaatg caacactaaa tgttgctaat
    14461 gtctttgctc aaaattggtc gattattgct cctattattt atggagtgat agcagcaatt
    14521 gcgatatata aaggagtatt acttgcaagt acaattgcca ctacggtagc atcttttgta
    14581 aattcattgt atgcagtagc agcgtataaa tcttgtgcag ctttagcagc acaagaattt
    14641 gcgatatttg gaaaaatatc tgcacaaacg atggaagctt tggtaacagc acaagcaaca
    14701 gcagcacaat ggggttttaa tgcagcatta ttatcctgtc caattttttg gataatagca
    14761 ggtattatag catttgtagt agtagttttt gttgcagtag cagcagtaaa caaattctca
    14821 ggaacaagtc tgactgtact aggagcaatt gtaggtgcag tatttgcagc agtagcattt
    14881 atacaaaaca taatgatatg gctatttaat agatgcgtag atgtaaatga agggattgca
    14941 aatggatgga atcaatgtgt atatctaatg aaacaagcta ttgcaaaagg tgtaatcttt
    15001 ataattgaga aaatggcatc attaaatgat gctgtaaata atgctggaaa tgcacttggg
    15061 aaagctttca tagatggggc aaatatcgca atacgaggtg taaacaaatt aattgaccta
    15121 ataaataaaa taccagggat aaatattggt aaagttggag aagcaacatt tacgcctgtc
    15181 aaggcagata atagttacat caaacaacag attgacagtt taaataaatg ggtaggagat
    15241 gcaccagaaa aaataaaatt ggatagaatg ggatataaag atattggagc agaatttcaa
    15301 aaaggaaatg cacttggaac taaatggcaa aatgctataa ctgataaatt taaagatact
    15361 tttgacatta ataagatgct agaagatgca aagaaaaaat taggattaga cgatttgtgg
    15421 aataaacaaa atcctttaaa caaccttggt ggatttggtg gagatttagg aaaaaatgta
    15481 aaagacacag caggaaacac agccaaaatg gctaaaacaa tggataaaag tcaagaagac
    15541 cttaaatact taagagacat tgcagaacaa gaaacaataa acagattcac aggagtaaac
    15601 ataaaaattg atatgaacaa tactaacaat ataagtaaag acacggatgt ggatggtata
    15661 gtaaatgttt taacagaaaa actgaatgat gctatgattg tatcagcaga aggaatagtt
    15721 tagaaaggag ggatataaat ggcttatgac ttttatttag atggagtaca attaccaata
    15781 cctccgccaa agttagagat taaagttaca aataaaaaca agatagttga tttgataaat
    15841 actggagaag taaacatact aaaaaaagaa ggattatctg aaataagttt tgaagcagaa
    15901 tttacacata ataagttgcc attctatcgt ggagctttta gggatgttca attcttttta
    15961 agtaaactgg aactattaaa aactgattgt aagccatttc aatttattgt atcgagggaa
    16021 ttaggtaata aagtactatt taacactaat ataaaagtat ctcttgaaga gtatgctatt
    16081 tcagaagatg cagaaaatgg ttcagataca aaagttgcaa taaagttaaa gcaatataga
    16141 gattactcaa ctaaaaagtt agttcttgcc cctcctaaaa atgagactgg tagacctaat
    16201 gtaaagatag agccaaaacg agttgattca gtcaatgcca caaacactaa aacatataca
    16261 gtaaaagcag gggatagcct ttggtcaatt tgtcagaagc aacttggtaa tggttcgtta
    16321 tacaagaaag tatatgagtt aaataaaaca atgatggata aagctaacaa gggtaaaaaa
    16381 gtacctaaat ataccatcta taaagggcag gtgttgaggc ttgtctgatg atttagttct
    16441 ggcgaatgat agagatataa ggctagttat tgcacattgg gaagatttct acgaacctgc
    16501 tgtcattgat ggtatcacat gggagataga aagaagaggt tcaccttcaa agttagagtt
    16561 tactatagca atggatgata tattagagtt ttgcgaaggt aattctgtaa ggatatatta
    16621 taagggaatt ggcatatttt atggatatat atttcagaag aaaagagata aagaaaatca
    16681 cattaaaata gttgcttatg accagttgag atattttaaa aataaagata cttatgtata
    16741 tagtaataaa acagcaagtg aacttgtaaa gatgttggct aaagatttta atttaaaata
    16801 caatgtcata gaagatacaa aatataaaat atcgagagtt gaagaaaata aaacactctt
    16861 tgatatggtc ttaactgcac tagatgatac tctaagagag aaaaaagaaa tgtatgtgtt
    16921 atatgatgat tttggaagaa taacattaaa gaatgttgca tcaatgaaat tagatactgt
    16981 tatgaacaat gatgtaatag aagactttga ctataattca tcaatagata gtgatactta
    17041 cacaaagatt aaacttgtga gagataatga agaaacagga aaaagagatg tgtatattgc
    17101 tcaagactca acgcatatga ggagttgggg aatacttcaa atgtttgata cagtagacaa
    17161 aaacatgagt gaagcagaga taaaacaaaa gtgtgatata cttctaaaac tatataataa
    17221 gaaaactaag tcattaagtt taaaaaatgt acttggagat attagagtga gagcaggttg
    17281 tttagtacct gtttttttaa atctaggaga tattaaactt caaaattata tgctagttga
    17341 gaaagtaaaa catacttttg aaaataacag tcattttatg gatttgactc ttgttgatgg
    17401 agatgaattt gcttcttatt cttcaagctc atattcaagt ggaaatacta acaataagga
    17461 tgaaaagaaa aatggtcctg cacaaagtat tacgaaaaaa aatacaggta aaaaagttcc
    17521 tgctatattt actgcatatt atccagggaa caatgcaatg gaaggcggaa aaacagattg
    17581 caatggaaag ccacttgatg taaaatcaag aactgttgct ggtccaatga atcgagaagg
    17641 agttaagaaa acttggtata ctgatgattt tctaaagaaa catccagttt ttgaatatgg
    17701 agataaagta aaaattatac ttcctggtac tgcctatgac aacaaagtat atacagttaa
    17761 agataatgga ggaagaatat atgttgaaac aaacggaaca tatcatatag atgtactatt
    17821 agctaatgct agtgaatgta aaaaatttgg tagaaagaat ggctatataa ttataggtgg
    17881 agatgaagaa caaacatatc aagttgaagg taataaccaa agtagtacaa ataataactc
    17941 taaagaagat aaattaatta gtatagcaaa aagtaaactg ggttgtaatt atgtgtatgg
    18001 agcagaaggt cctaataatt ttgattgcag tgggtttact caatggtgtt ataaacaaat
    18061 aggtataaaa attcctcgta ctgcttctgc acaaagtaaa gcaggaaaag cagtagattt
    18121 aaaagataga agcaagtgga aagcaggaga cttattatgt agaattggag gaggaagtag
    18181 taatcatgtt gtaatgtata ttggaaacaa tcaaataatt cattcaccac aaacaggaga
    18241 tgtggtaaaa atagagtctg ttaattctta tagaaaagga aaagcataca cacatgtgag
    18301 aagatttata taagtgaggt ggcaatatga gccaagattt attacagata ataaaaaaag
    18361 ctgcaatgga tgcagtagaa acaagcaacc caatgagggt tgtatttgga acaatagaaa
    18421 gtattagtcc tctaagagtt aagatagaac aaaaactatc tattggtgaa atttttctaa
    18481 tacaaacaga tacatttaaa agatatacag ataaaaaaat aggagataaa ttagtcttaa
    18541 ttcgtatgca aggagggcaa caatacttga ttttagatag gatgtgataa agtgttacca
    18601 agtgataatt tagattatga tattgaagat gtatcaataa ttaattttga tgtaagacaa
    18661 gagccaagta agacatttaa acttcatata gaaaagtcta agattgatgg tatttgtgat
    18721 gatgtagaag cattaaaaca gaccatcttt ttgattttaa acacagagag ataccaacat
    18781 ctaatatata gttggaatta tggagtcgag ttgaacgacc ttattggaga gcctatatcc
    18841 tttgtaatac cagagttaga gagaagaatc aaagaagcac taattcaaga tgatagggtt
    18901 gaaaatgtag ataattttga gtttgaaaat ataaagggta aagtacaatg taaattttca
    18961 gttcatacaa aatatggaaa tataaaagca gagaaggtgg tgagtgtata attgtttgag
    19021 ttaatgacat ttgaaaatat aattaaaaga atgttagata gtgtacctaa cacacttgat
    19081 aagagagaag gttctataat atacaatgcc ttggcaccag ttgcagtgga gcttacagaa
    19141 acatatattg ctatggatga attactagac caaacattcg tagatactgc tagttattac
    19201 tatttagaga agagatgtaa agagcgagga attacacctt taccagccac taatacaatt
    19261 gctaaaggag tttttaacat agatattcca cttgattcta ggtttaatct aggagaatac
    19321 aattatattg caattgagag aatatctgaa aaaacatata aaatgaaatg tgaaactgct
    19381 ggacctatat ttgagttagg aaaactaata cctattgaat atatagatgg tcttgaaact
    19441 gctgaactaa ctgaaatctt gataaatgga gaggatgaag agtcagaaga tagtttaaga
    19501 caaagatatt atgatagcct aaattcacag agctttggtg ggaatataca aaa
//
LOCUS       DAEPID010000074        19196 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.074, whole genome shotgun sequence.
ACCESSION   DAEPID010000074 DAEPID010000000
VERSION     DAEPID010000074.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 19196)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 19196)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..19196
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.074"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            160..681
                     /locus_tag="KR257_002950"
     CDS             160..681
                     /locus_tag="KR257_002950"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454764.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="HBH0031622.1"
                     /translation="MDIAKLILNPARLRILQYIRLYGSVRTSDIVKYLNDIPRATVYH
                     HVKILEENNMIEVIKENRVRGTIEKVYALKEYTTSMEGETFVALSTAFYVGLMQEMNE
                     YFSRKEQDHKKDNVFFSSALLYMSDNEYENLLKSIADLLKPYIEQKPKSNLKLRKLSI
                     ISSPPVADNDKTK"
     gene            715..1491
                     /locus_tag="KR257_002951"
     CDS             715..1491
                     /locus_tag="KR257_002951"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890682.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha/beta hydrolase"
                     /protein_id="HBH0031623.1"
                     /translation="MKFHEFGNKNRPHIMLIHGGGNAWWNYLRQAEVLSNKYHVILPT
                     LDGHGEEYETTYISTEDTADKLISYIDENCSGHLFALCGVSLGGQIVMELLSRKPNIT
                     KKAIIDGSICYPRPLMARFCIAGIRFFGGLLFSEKACRFQIAMMPKLLPENMQYPDEI
                     KAYYMTDMPHVRKETFYNMYRTYMMNYTLKENVKKTTAQVMYWYGEKEMKCVKKSAKL
                     FQSYVPSCEIYEAKSYNHGYLSLYLPNEWLEIAEPFFQKE"
     gene            1833..2786
                     /locus_tag="KR257_002952"
     CDS             1833..2786
                     /locus_tag="KR257_002952"
                     /EC_number="3.4.24.78"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430954.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GPR endopeptidase"
                     /protein_id="HBH0031624.1"
                     /translation="MISVRTDLALEASEMCEKSQEGSSIPGVKIETKELENCIVTKVE
                     VIDRQGAEIMNKDIGKYITLESNLMKFDDDESREEMISYLKEELVDIFGQDKNKKTLV
                     IGLGNRNITSDALGPKSVSKTLVTRHLFKNYNKDYDDDFTEVSALSPGVMGVTGIETS
                     EIVKSLVEKVKPDRVVAIDALASRKMERVNSTIQISTAGISPGGGVGNTRKSLTKETL
                     GVDVIAIGVPTVVDAATLTIDVLDMAIDNLIAQSEETESFYEMLKKLKEEEKYHLIKD
                     SLDPYDKNLIVTPKDIDDTIENLSIIISEGLNRSLHPGRLV"
     gene            2804..3823
                     /locus_tag="KR257_002953"
     CDS             2804..3823
                     /locus_tag="KR257_002953"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897656.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="stage II sporulation protein P"
                     /protein_id="HBH0031625.1"
                     /translation="MFKKCIKVVTLTFILVCILPGKSLALNQDDFLKFLVNSSYPEAK
                     VEGNDTENKKNNKNKETSKENKEESKEGNTKSKDASKVDNKKESEKEYIKLYVGKENV
                     PDIESKNSDTTETNTTSSSDYKDDLRVTKENPRILIYHTHGCETYSNSPDGNYHSRDK
                     KNSVMEVGSALTSALDSKGWGVVHTTKYHDYPSYNNSYASSLKTIQSILPKYNSVDIA
                     IDLHRDARDLTNPATKEKDHLKYTTMINGERVSKFFFVVGGKNTNRKQLRALAEDITA
                     FAEKKYPGLVSPIVEKDYARFNQFAVKNHMLVEIGNNATSVEESKATTKYLAEILDEY
                     FKQKN"
     gene            3854..4105
                     /locus_tag="KR257_002954"
     CDS             3854..4105
                     /locus_tag="KR257_002954"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430948.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0031626.1"
                     /translation="MSRLEKNIESKSKLRKYKYIMRILFLITMIICTSVCVFIVDSNA
                     KSMLGMKQYDFPSIKFDITKFDFDIPNFDIHEIIKKFNK"
     gene            4387..6192
                     /gene="lepA"
                     /locus_tag="KR257_002955"
     CDS             4387..6192
                     /gene="lepA"
                     /locus_tag="KR257_002955"
                     /EC_number="3.6.5.n1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430946.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="elongation factor 4"
                     /protein_id="HBH0031627.1"
                     /translation="MDNKQSRTRNFSIIAHIDHGKSTLADRLIQQTGLVSERDMKSQL
                     LDNMDLERERGITIKLQNIRLMYKAKDGNEYYLNLIDTPGHVDFNYEVSRSLAACEGA
                     LLVVDAAQGVEAQTLANVYLAIDQDLEILPIINKIDLPSARPEEVKNEIEDLIGLDSS
                     EAPLISAKTGLNIEDVLEDIVKNVPPPKGDNEAPLKALIFDSYYDAYKGVVAYVRVFE
                     GTVKKGMTIKMMNTNKKFEVTEVGVMAPGQTELSELSAGDVGYIAASIKDIRSCRVGD
                     TITDSNNPTEEPLPGYKKATPMVYCGIYPGEGEKYENVRDALEKLQVNDAALEYEAET
                     SAALGFGFRCGFLGLLHMEIMQERLEREFNLDIITTAPSVIYRVTKMDGEVVMIQNPA
                     NLPEPSEIKMIEEPIVKGDIIVPKDYVGVVMELCQERRGNMLNMEYIDDRRVMLHYDL
                     PLNEVVYDFFDALKSRTRGYGSLDYEVKGYVASTLVKLDILINKEQVDALSFIVHETR
                     AFPRGKAMCEKLKGEIPRHQFAIPIQAAVGNKVIARETISALRKDVLAKCYGGDISRK
                     KKLLEKQKEGKKRMRQIGSVEVPQKAFMSVLKLDE"
     gene            6341..7678
                     /locus_tag="KR257_002956"
     CDS             6341..7678
                     /locus_tag="KR257_002956"
                     /EC_number="2.7.7.72"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897653.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CCA tRNA nucleotidyltransferase"
                     /protein_id="HBH0031628.1"
                     /translation="MINIEIPKKVDYIIKELEKNGYEAYIVGGCVRDCLLERVPNDWD
                     ITTSARPEVVVELFEKTIPTGIQHGTVTVMIEHEPFEVTTYRIDGNYSDGRHPDSIEF
                     TNNIVKDLSRRDFTINSIAYNSKTGLVDPFNGYEDIQNKYIRCVGNPVDRFEEDALRM
                     LRAVRFSAQLNFKIAEGTKQSIHKKADLIKNVSIERIQTEFNKILVSDSSKLNLLKST
                     GLLKFIIPEICELEDVTQHNPYHIYDVQKHTLIATEVIEDELYLKLTMLFHDLGKKVT
                     KTTDKNGVDHFYTHSRESVKIAKKILKRLKYDNYTINKVLILIQYHDYRIEPKRKIIK
                     KLLNKLEDVELFEDLIKVNWADTLAKNPKYAKQKILNLIECEKEFKHIINQKECFNLK
                     DLAINGKDLISIGIKPGKDIGYILNKMLEIVINNPELNEKEILKEKALNIYTF"
     gene            7911..9224
                     /locus_tag="KR257_002957"
     CDS             7911..9224
                     /locus_tag="KR257_002957"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893607.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amino acid permease"
                     /protein_id="HBH0031629.1"
                     /translation="MHTQLQKTIGLSAALSTVVGMVIGSGVFFKPQAIYTTTNGAPGL
                     GIIAWLLGGFITITAGLTATEISAAIPKTGGMMIYIEEIYGEKLGFLTGWMQTVLFFP
                     GTSAALGVIFAQQASELLGMSPNNMANVLPIAIGVILFLALLNIIGSSLGGKVQTVAT
                     IGKMIPLILIIVFGFIKGQSSEVLNPFVGDGVNASNALGQVLIATLFAYDGWINVGAI
                     SGEMKSPEKDLPRAIVGGLSLVMAVYIIINIAYLWVVPASELATVTSPATLVATRLFG
                     NIGGKVITVGILISVFGTLNGYLLTGSRIPYTLAEMGTLPASKTLLKVNSGGSPVNSI
                     LLITVLACVYALSGQFNLLTDLTIFSIWVFYVLTFIGVMRLRRQKPDLHRPYKVPLYP
                     IIPIIAILGGLFVIINQILTSTVISLGGIFITLLGLPVYYYMKKR"
     gene            9396..10571
                     /locus_tag="KR257_002958"
     CDS             9396..10571
                     /locus_tag="KR257_002958"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416563.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="oxygen-independent coproporphyrinogen III
                     oxidase"
                     /protein_id="HBH0031630.1"
                     /translation="MLGLYVHIPFCVKKCKYCDFNSYKMDIDSKKRYIEDLKIEMELY
                     SNKLYKDNKYKNKECCSLNKNDKITSIFVGGGTPSILTSDEIREVFISIKEMFDIDEN
                     AEITIECNPGTLTLEKLKTMKEIGINRLSIGLQAIQEKHLNFIGRIHTYEEFEKNYKD
                     ALSVGFKNINIDLMYSLPNQTLCDWKETLEKVVHLNPTHISAYSLILEEGTELYNMYE
                     SNKFELIDENVDIEMYEYTINYLKSKGYNQYEISNYSKEGYNCEHNILYWECEHYIGI
                     GAGASGYINENRYNNVESLEDYHLSLVKREKPIQENEILSEKDMIEEKIFMGLRMNKG
                     IKFEDFKKKFGIDFREKYNKQIEMLLARKLINQSFEGIQLTQKGREISNSVFIEFME"
     gene            10674..11693
                     /gene="hrcA"
                     /locus_tag="KR257_002959"
     CDS             10674..11693
                     /gene="hrcA"
                     /locus_tag="KR257_002959"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416565.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="heat-inducible transcription repressor HrcA"
                     /protein_id="HBH0031631.1"
                     /translation="MELNERKLNILKAIVKDYIETAEAIGSRTISKRHDLGVSAATIR
                     NEMADLEELGYLIQPHTSAGRVPSEKGYKLYVNSLMSKSELDDNDKILIEQCMNHNIN
                     HIKELIHETSKLLSQLTNYTTVAVTKSLINQSVIKHIQLVAMNDNNILLIVVTDKGDL
                     KKANLTTNVYLDQSKLNLISDNLTRKLLGKSITDLDDNLIAFIKYEISEYSGLIDELL
                     NALNSNMKEEDFSLSLNGATNIFSYPEFNDVLKAKSFLNMLEKKETIADIIKSKGIQK
                     DNLNIIIGSDNDCELAQDCSIVTATYNVDRDLVGRISFIGPTRMDYARIYSIINYMSL
                     LINRK"
     gene            11723..12343
                     /gene="grpE"
                     /locus_tag="KR257_002960"
     CDS             11723..12343
                     /gene="grpE"
                     /locus_tag="KR257_002960"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430935.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nucleotide exchange factor GrpE"
                     /protein_id="HBH0031632.1"
                     /translation="MDKKNEQQEVREENDTSINQESETQVELEEEVVNEECETSSEKT
                     DEKEVDDENVTDINSKLAEKKLQDELDELNDKYQRLQAEYANYRRRTQQEKETIGVFA
                     NEKIITELIPVIDSMERALDACEDKEDTMYKGISLVHKQLIDTLVKFGVEEIEAESKE
                     FDPNLHLAVMQESVDGVEANQIVMVLQKGYKLGTKVVRPSMVKVSC"
     gene            12435..14282
                     /gene="dnaK"
                     /locus_tag="KR257_002961"
     CDS             12435..14282
                     /gene="dnaK"
                     /locus_tag="KR257_002961"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000034699.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="molecular chaperone DnaK"
                     /protein_id="HBH0031633.1"
                     /translation="MGKIIGIDLGTTNSCVAVLEGGEAQIIANSEGMRTTPSVVAFTK
                     DGERIVGEPAKRQAVTNADKTITSIKTHMGTDYKVNIDGKSYTPQEISAIILQKLKSD
                     AESYLGQTVTEAVITVPAYFTDAQRQATKDAGRIAGLDVKRIINEPTAAALAYGMDKL
                     DQEKKILVFDLGGGTFDVSILEIGDGTFEVLATAGNNRLGGDDFDQIVIDYLAEEFKK
                     AEGVDLRNDKMALQRLKEAAEKAKKELSSTMSSNINLPFITATAEGPKHLNIDLSRAK
                     FEELTRGLVEKTMEPTKTALQDAGLSTGDIDDVLLVGGSTRIPAVQEAVKKFIGKEPH
                     KGINPDECVAAGASIQAGVLAGDVKDLLLLDVTPLSLGIETMGNVMTKIIERNTTIPT
                     KKSQIFSTAADNQTAVDIHVLQGERSMAYDNTTLGRFQLTDIPPAQRGIPQIEVTFDI
                     DANGIVNVSAKDLGTGKEQKITITSNTNLSESEIEQKIKEAEMNAEADKQKKEKIEAF
                     NQAESTIYQTEKTLNELGDKISSGEKEDIEKAIADLKAVKDNQDATAEELKKATDEVM
                     TKFQKVSQEMYQKAAQEQQAAQGAEQAQDNGPKDDNVVDADFKEVDEDK"
     gene            14493..15647
                     /gene="dnaJ"
                     /locus_tag="KR257_002962"
     CDS             14493..15647
                     /gene="dnaJ"
                     /locus_tag="KR257_002962"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454751.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="molecular chaperone DnaJ"
                     /protein_id="HBH0031634.1"
                     /translation="MSTKRDYYEVLGISKGAEAQEIKKAYRKLAMKYHPDRNPGDKEA
                     EEKFKEINEAYEVLSDDTKRKTYDQFGHDGLNGQGGFGGQGGFGGQGFGGFEDMFGDI
                     FGDMFGGSFGGGRARRRGPQRGADIRQSVTISFEEAAFGKKMSIKVNRSEECEECNGT
                     GAKPGTSKKTCSTCNGTGQVRTVQRTPFGNIASSRPCSACNGTGEVIESPCSKCHGTG
                     NTRKVKTIEVDIPAGIDDGQMIKLSGQGEVGEKGAPRGDLYIVVNVKSHPLFTRDGND
                     IYFEMPITFVQATLGDEIEVPTLDGKVKYSVPEGTQTGTVFRLKEKGIPRIRGNSRGD
                     QYVKVVVEIPKKLNDKQKELLREFAKECGSNVHEKKKTFGQKIEDMFKKK"
     gene            16613..17548
                     /locus_tag="KR257_002963"
     CDS             16613..17548
                     /locus_tag="KR257_002963"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890668.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ROK family protein"
                     /protein_id="HBH0031635.1"
                     /translation="MYYIGVDIGGTGIQAGVVDNYGKIIFRSECKTVIEKGFEGILND
                     IKIMIYKLLEDNKLTMSDIKSIGFGVPGFINKEGLVTCVNLKWNKKAFNKELKKRFPD
                     VEIHGENDATVAALGEAKFGSMKGANVGVLYTLGTGVGGGIVINQKVFSGAHGLGSEI
                     GHQIIGENYFNCNCGNNGCVETFCSATAIIKYSQKLIEEGEKSRILDLAEGNLENVNA
                     KMVFDAYRENDLVAIKVINRFKEYLAKTFANTINSLDPEIISIGGGISKSSDIILDGI
                     EGLVRKFVLYKTEDIATITCATLGSDAGIIGAAFL"
     gene            17584..18957
                     /locus_tag="KR257_002964"
     CDS             17584..18957
                     /locus_tag="KR257_002964"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897645.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MFS transporter"
                     /protein_id="HBH0031636.1"
                     /translation="MGKTNARRTLFLIAIGSGTMLNPLNSSMISLALHSIQNDFHISF
                     TTVSWIVSAFYLASAIAQPVSGKIGDLIGRKVLFLSGLMLVILSASIVPLVQSFFILI
                     FIRVIQAIGTSTLYPSGVALIQNNIKERQSSALAVLTIFASTTAGLGPTLGGLLLDLG
                     GWHAIFLVNIPVVLVSICLGYFLFPKEVKEKKSIKETLKNVLSRLDIIGILLFSIAMI
                     FILLFLLSMKESFNLEQLVFGIILMCLFIWHELRTKLPFIDIKLFVSNPKLSKVYLQF
                     IILNFFNYILFFGLPSYFQDALHYSAKSTGLFMLFMSGIGIFISPLTGKWIDKSGTRF
                     PLVTSSIFMFISAVLLSVVFIHIPVIGKGIILSLAGISYGVGNVALQSSMFEESPRDS
                     IGTASGLFQTSRYLGSILATVLLGMVFEVNITSEQFQILGYVMVVLGTISFLLNFILK
                     KELRKVE"
BASE COUNT         7612 a         2107 c         3511 g         5966 t
ORIGIN      
        1 ctaatatgtt agaaggttat atgtaattaa tgtcagtgtt tatatagaat agcatttgta
       61 gcatttatta tagttgtaat tactatttat atcatagact tgaatagtct aaaaaaatag
      121 actataatat ttttatagac taaagaaagg gctgataaga tggacatagc aaaactaatt
      181 ttaaatcctg caaggcttcg tattttacaa tatattcgac tttatggcag tgttcgtaca
      241 tctgatattg taaagtattt aaatgatatt cctcgtgcaa cagtttatca ccatgtaaaa
      301 attttagaag agaacaatat gattgaagta attaaagaaa atcgtgtgcg tggtactatt
      361 gaaaaggttt atgcactaaa ggaatataca acatctatgg aaggagagac cttcgttgca
      421 ctttctacag cattttatgt aggtctgatg caggaaatga atgaatactt tagcagaaaa
      481 gagcaagacc ataaaaagga taatgtattt ttctcttcag cattactata tatgagtgat
      541 aatgaatatg aaaatcttct taaaagtata gctgatttat tgaaaccata tatagaacaa
      601 aaacctaaat caaatctaaa acttagaaaa ctttcaatta tatcttctcc acctgtagct
      661 gataatgata aaacaaaata acatgcaacc catttttata aaaggaggtt atatatgaaa
      721 tttcatgagt ttggaaataa aaacagacca catattatgt tgattcatgg gggagggaat
      781 gcatggtgga actatttgcg acaagcagaa gttttgtcta acaaatatca tgtgatactt
      841 cctacattgg atggtcatgg agaagaatat gaaacaacat acatttctac agaggataca
      901 gcagataagt tgatatcata tatagatgaa aattgcagtg gacatctttt cgctttgtgt
      961 ggggtatcac ttggtggtca aattgtcatg gaacttttat ctcgaaaacc taatattact
     1021 aaaaaagcaa ttattgatgg tagtatttgc tacccaagac ctcttatggc aaggttttgt
     1081 attgctggta ttcgattttt tggaggactt ttgtttagtg agaaggcttg tcgctttcaa
     1141 attgctatga tgccaaaatt gttacctgaa aatatgcaat atccagatga aataaaagcg
     1201 tattatatga cagatatgcc acatgtaaga aaagaaacat tctataatat gtatcgtact
     1261 tacatgatga actatacact taaagagaat gttaaaaaaa ccacagcaca agtaatgtac
     1321 tggtatggag aaaaagaaat gaagtgtgtc aaaaaatctg caaaactgtt tcagtcttat
     1381 gtgccctctt gtgagattta tgaagctaag agctataatc atgggtattt atcactttat
     1441 cttccaaatg aatggttgga aattgcagaa ccatttttcc aaaaggaata aaggtgttag
     1501 gtgattattg tataattatt gctgtttttt tatatagtaa ataaattagg tataaatata
     1561 aaaaattatt ttagttaata tattagtgaa agcttaatag gaaaattata aatagattaa
     1621 aggtagcacc tatataaata gttgctacct ttttctgttt gtaaataaat gatagataag
     1681 aaggtttact gacaaatcac tgactaaacc caattttctt acattgaaag ccttaatttt
     1741 acttgtttta aataaattta caatttcttg ttataaaata ctaaattttg ttaacaatta
     1801 taattagcat ttaatttata ctggaggttt atatgattag tgtaagaaca gatttagctt
     1861 tagaagctag tgaaatgtgt gaaaagtctc aagaaggaag tagtattcct ggtgtaaaaa
     1921 tagaaactaa agaattagaa aattgcattg taactaaagt tgaagtaata gacaggcaag
     1981 gcgcagagat aatgaataaa gatataggaa agtatataac tctggaaagt aatcttatga
     2041 agtttgatga tgatgagtca agagaagaaa tgataagtta tttaaaagag gagttagtag
     2101 atatatttgg ccaagacaaa aataaaaaaa ccctggtaat tggtcttgga aatagaaata
     2161 ttacttctga tgcgttagga ccaaagagtg tatcaaaaac acttgtaact agacatcttt
     2221 ttaaaaatta taataaagac tatgatgatg atttcactga ggtatcagct ttaagcccag
     2281 gagttatggg tgttactgga atagaaacta gtgaaatagt aaaatcattg gttgagaagg
     2341 ttaagccaga tagagtagta gcaatagatg cattggcttc aagaaaaatg gagagagtaa
     2401 actctactat acagatatca acagcaggaa tatcacctgg tggaggtgtt ggcaatacta
     2461 gaaaatctct aactaaagaa actttaggcg tggatgttat tgcaataggc gttccaacgg
     2521 tggttgatgc agcaactctt acaatagatg tcttagatat ggcaatagac aatttaatag
     2581 ctcaatcaga agaaacagaa agtttttatg aaatgttgaa aaaacttaaa gaagaagaaa
     2641 aatatcatct aataaaagat tcgttagacc catatgacaa gaacttaata gtaacaccaa
     2701 aggatataga tgatacaatc gaaaatctat ctataataat aagtgaaggc ttaaataggt
     2761 ctttacatcc aggtagattg gtataaaata aggaggagca attatgttta aaaaatgcat
     2821 taaagtagta accttgactt ttatattagt atgcatttta ccaggaaaat cattagcttt
     2881 gaatcaagat gattttttaa agtttttagt aaattcatct tatccagaag ctaaagtcga
     2941 aggaaatgat acagaaaata aaaagaataa taaaaataaa gaaacaagta aggaaaataa
     3001 ggaagaaagt aaagaaggaa acactaaatc taaagatgca agtaaagttg ataataaaaa
     3061 agagagtgaa aaagaatata taaaacttta tgttggtaaa gaaaatgttc cagatattga
     3121 gtcaaaaaat tcagacacaa ctgaaactaa cacaacatct agttcagatt ataaggatga
     3181 tttaagagta accaaagaaa atccaagaat tttgatatat catactcatg gatgtgagac
     3241 ttattcaaat tcacctgatg gaaattatca ttcaagagat aagaaaaatt cagtaatgga
     3301 agtaggaagt gcattaacta gtgctttaga tagcaaagga tggggtgtag tccatactac
     3361 taaataccat gactatccat cttataataa ctcttatgca agtagcttaa aaacaataca
     3421 aagtatatta cctaaatata actcagtgga tatagcgata gacttacata gagatgctag
     3481 ggatttaact aatccagcca ctaaggaaaa agaccattta aaatatacaa ctatgataaa
     3541 tggagagaga gtatcaaagt tcttctttgt tgtaggaggt aaaaatacaa atagaaaaca
     3601 acttagagct ttagcagaag atataactgc ttttgctgag aaaaagtatc ctggtctagt
     3661 atctccaata gtagaaaaag actatgctag attcaatcag tttgcagtta agaatcatat
     3721 gttagtagaa atagggaata acgcaacaag tgtagaagaa tctaaggcta ctacaaagta
     3781 tttagccgag attttggatg aatattttaa acaaaaaaat tagagcttta agttataatt
     3841 aggagcatgc taaatgagcc gattagaaaa aaatatagaa agtaaaagta aactaagaaa
     3901 atacaagtat attatgagaa tcttattttt gattactatg attatatgta catcagtttg
     3961 tgtatttata gtggacagta atgcaaaaag tatgctagga atgaaacaat atgattttcc
     4021 aagtattaaa tttgatataa caaaatttga ttttgacata ccaaattttg atatacatga
     4081 aatcataaaa aaatttaata agtagtaata agtgaataag gtttattgat taaaataagc
     4141 cttattttag ttatatattt ttaatgtata aaataaaaat tcattaactg tattttatag
     4201 gatttacttt aagtttatga tattatataa tatttagtgt tagacttgat aatccacata
     4261 taatgtggat aattttgttt agtgccaatt agtttatatt caaaaatttt aaatttggta
     4321 tataaagagt ttttagataa tgtaaaataa taactataag aataatcaag aggagggaat
     4381 tttaaggtgg acaataaaca aagtagaact agaaatttta gtataattgc acatatagac
     4441 catggaaagt ctaccttagc tgatagatta atacaacaaa ctgggcttgt tagtgaaaga
     4501 gacatgaaaa gtcaattact tgacaatatg gaccttgaaa gagaaagagg aatcactata
     4561 aagcttcaaa acataagatt aatgtataaa gcgaaggatg gaaatgaata ttatttaaat
     4621 cttatagata cacctggaca tgtagacttt aactatgagg tatcaagaag tttagctgca
     4681 tgtgaaggag cactattagt agttgatgca gctcaaggtg ttgaggcaca aactttagcc
     4741 aatgtttatc ttgctataga ccaagattta gaaatattac caataataaa taaaatagat
     4801 ttaccaagtg caagaccaga ggaagtaaaa aatgaaatag aagatttaat agggcttgat
     4861 tcaagtgaag ctcctcttat ttcagctaaa actggtttaa acatagaaga tgttttagaa
     4921 gatattgtaa aaaatgttcc tccacctaaa ggagataatg aagctccatt aaaggcatta
     4981 atattcgatt cttactatga tgcttacaaa ggtgttgtag cttatgttag agtatttgaa
     5041 ggaactgtta aaaagggtat gacaataaaa atgatgaata ccaataaaaa gtttgaggta
     5101 actgaagttg gtgttatggc tccaggtcaa actgaactta gtgaattatc agcaggtgat
     5161 gttggttata ttgctgctag tataaaagat ataagaagtt gtcgtgttgg tgatacaata
     5221 acagattcaa ataatcctac agaagaacct ttaccaggat acaaaaaagc tactccaatg
     5281 gtatattgtg gtatatatcc aggagaagga gaaaagtatg agaatgttag agatgctctt
     5341 gaaaagcttc aagtaaatga tgctgcactt gaatatgaag ctgagacttc agcagcacta
     5401 ggatttggtt ttagatgtgg tttcttaggt cttttacata tggagataat gcaagaaaga
     5461 cttgagagag aatttaacct tgatataatt actacagctc catctgttat atatagagtt
     5521 acaaaaatgg atggagaggt tgtaatgata caaaatcctg caaacttacc agaaccatct
     5581 gagataaaga tgatagaaga gcctatagta aaaggagata taatagttcc taaagactat
     5641 gtgggtgttg ttatggagct ttgccaggaa agacgtggaa atatgttaaa tatggaatat
     5701 atagatgata gaagagtaat gcttcactat gaccttcctc tcaatgaagt tgtttacgat
     5761 ttctttgatg ctttaaaatc aagaactaga ggttatggtt ctcttgatta tgaggttaaa
     5821 ggttatgtag catctacact tgtaaaactt gatatattaa tcaataaaga gcaagtggat
     5881 gcacttagtt ttattgtcca tgagacacgt gctttcccta gaggaaaggc aatgtgtgag
     5941 aaattaaaag gagaaattcc aagacatcag tttgctatac caatacaagc tgctgttggt
     6001 aataaggtta ttgcaagaga aacaataagc gctctaagaa aagatgttct tgctaaatgt
     6061 tatggtggag atatatctcg taagaagaaa cttcttgaaa aacaaaaaga aggtaagaag
     6121 cgtatgagac aaattggttc tgttgaagtt cctcaaaaag catttatgtc tgtgcttaaa
     6181 ttagatgagt aaatccttat aaatttagat aaagatattt aaaagctaga gtgattttag
     6241 aattatttct aaattagtct agctttttta tggtatattt taagtaaact catagagaat
     6301 ataagtaaga atattaaaga agaataaaaa ggtgatattt atgattaata tagaaattcc
     6361 taaaaaagta gactatataa ttaaagaatt agaaaagaat ggttatgaag cttatatagt
     6421 tggaggatgt gttagagatt gtttattaga aagagttcca aacgattggg atataacaac
     6481 tagtgctaga ccagaagtgg tagtagaatt atttgaaaaa acaattccaa ctggtataca
     6541 acatgggact gtaacagtta tgattgaaca tgaaccattt gaagtgacga cttatagaat
     6601 tgatggaaat tatagtgatg gtagacatcc agattcaata gaatttacaa ataacatagt
     6661 taaggacttg tcaagaagag attttactat caattcaatt gcatacaatt caaagacagg
     6721 attagtcgac ccatttaatg gctatgaaga tatacaaaat aagtatatac gttgtgttgg
     6781 aaatccagta gatagatttg aagaagatgc acttagaatg cttagagcag ttagattttc
     6841 agcacaactc aattttaaaa tagctgaagg tactaagcaa agtattcata aaaaagcaga
     6901 tttgataaaa aatgtttcta ttgaaagaat ccagacagag tttaataaaa tattagtatc
     6961 tgattcatct aaattaaact tattaaaatc aacaggtttg ttgaaattta taattcctga
     7021 aatatgtgaa ttagaagatg ttactcaaca caatccatat cacatctatg atgtacaaaa
     7081 acatacttta atagctacag aagtaattga agatgaactg tatttaaaac ttacaatgtt
     7141 gtttcatgat ttaggtaaaa aagtaactaa aacaactgat aaaaatggtg ttgaccattt
     7201 ttatactcat agtagagaat ctgtaaagat tgcaaagaag attttgaaaa gacttaagta
     7261 tgataattat actattaata aagttttaat attaatacaa tatcatgatt atagaataga
     7321 acctaaaagg aagataatta aaaagttatt aaataaactt gaagatgttg aattatttga
     7381 agatttaata aaagttaatt gggctgatac acttgcaaaa aatccaaagt atgcaaaaca
     7441 aaagatatta aatcttattg agtgtgaaaa agaatttaaa catataataa atcaaaagga
     7501 gtgctttaat cttaaagatt tagctattaa tggaaaagat ttgatatcta taggtataaa
     7561 accaggtaaa gatataggat atattttaaa taagatgctt gaaatagtca taaataatcc
     7621 agagttaaat gaaaaagaaa tactaaaaga aaaagcatta aatatatata cattttagat
     7681 tcaaatataa aaaatttaat tactttaaaa aacatagaat aaaatactta tttagataaa
     7741 ataaataatt tttagagaat attttagaag ttacgattgt atgattttta aatgcatagg
     7801 catttactct aggactatag actaatataa aaaaaaactt tgggaatact aaaaccataa
     7861 atttataaaa ttaatatttt atatactgta aaacagtgag gagggacagt atgcatactc
     7921 aactacaaaa gactattggt ctttcagcag ctctttctac tgttgtaggt atggttatag
     7981 gttcgggagt tttttttaag ccacaagcaa tatacactac aactaatgga gctccaggtc
     8041 taggtattat agcgtggctt ttaggtggtt ttataacaat aactgctggg cttacagcta
     8101 cagaaatttc agctgctata ccaaaaactg gtggtatgat gatttatatc gaagaaatat
     8161 atggagaaaa gttaggtttt ttaactggat ggatgcaaac tgtattattt ttcccaggta
     8221 catcagcggc attaggagta atatttgctc aacaagcatc tgaactttta ggaatgagcc
     8281 caaataatat ggcaaatgta cttcctatag caattggagt tatactattt ttagcgttat
     8341 taaatataat aggttcatcc ttaggaggaa aagttcagac agtagccact attggaaaga
     8401 tgataccttt aattttaata atagtctttg gatttattaa aggtcaaagt agtgaagtat
     8461 taaatccatt tgtaggagat ggtgtaaatg catcaaatgc acttggacaa gtattaatag
     8521 ctactttgtt tgcatatgat ggttggataa atgttggagc tatatcagga gaaatgaagt
     8581 ctccagagaa agatttacca agagcaatag ttggtggttt atcattagtt atggcagttt
     8641 atattataat aaatatagct tatctttggg tagtaccagc aagtgaatta gcaacagtta
     8701 cttccccagc tacattagta gcaacaagat tgtttggaaa tataggtgga aaagtaataa
     8761 ctgtgggtat attaatatca gtatttggga cattgaatgg atatttatta acaggttcaa
     8821 ggatacctta tacattagct gaaatgggaa ctttaccagc atctaaaact cttttaaaag
     8881 taaattctgg aggttctcct gtaaattcaa tactacttat aactgtgtta gcctgtgtat
     8941 atgcattatc tggtcaattt aatcttttga cagacttaac aatattttca atatgggtat
     9001 tttatgtatt gacttttata ggtgttatga ggcttagaag acaaaagcca gatttacaca
     9061 gaccatataa agtcccttta tatccaataa taccaattat agctatatta ggtggactgt
     9121 ttgtaataat aaatcaaata ttgacttcaa cagtcatatc tttaggcgga atatttataa
     9181 cactattagg tttaccagtt tattattata tgaaaaaaag ataactactt aatttaagtt
     9241 agataaattt gggtaaaggt gaaaattaac ttttatccaa attttttata ctgttataca
     9301 atataagtat tatatattgc ttgatgtgct attttgtttg atttataatt tagtaattga
     9361 tgttttaaga taatttaaga aatgaggagt gaaagatgct aggactttat gtacatattc
     9421 cattttgtgt gaaaaaatgt aagtattgtg attttaattc ttataaaatg gacatagatt
     9481 caaaaaaaag atatatagaa gacttaaaaa tagaaatgga attatatagt aataaattat
     9541 ataaagataa taaatataaa aataaagaat gctgtagtct aaataaaaat gacaaaataa
     9601 cgagtatatt tgtaggggga ggtacaccta gtatactaac ctctgatgaa ataagagaag
     9661 tatttataag tataaaagaa atgtttgata tagatgagaa tgcagaaata actatagagt
     9721 gtaatcctgg gacattaaca ttagaaaaat taaaaactat gaaagagatt ggcataaata
     9781 gacttagtat agggctacaa gctattcaag aaaagcattt gaactttata ggaagaatac
     9841 atacttatga agaatttgag aaaaactata aagatgcatt aagtgtaggt tttaaaaata
     9901 ttaatataga tttaatgtac agtcttccaa atcaaactct atgtgattgg aaggaaactc
     9961 ttgaaaaagt tgtacactta aatccaacac atatatcagc ttattccctt atactagaag
    10021 aaggaactga actatacaat atgtatgaaa gtaataaatt tgaacttata gatgaaaatg
    10081 tagatataga aatgtatgag tatacaataa actacttaaa gtcaaaagga tataatcaat
    10141 atgaaatatc caactactca aaagaaggct ataattgtga gcataatatt ttatattggg
    10201 aatgtgaaca ttatataggg attggagcag gagcttctgg ctatattaat gagaacagat
    10261 acaataatgt agaatcttta gaagattatc atttaagttt ggtaaaaaga gaaaaaccaa
    10321 tacaagaaaa tgaaattctt tctgagaaag atatgataga agaaaagata tttatggggc
    10381 ttagaatgaa taaaggcata aaatttgaag attttaaaaa aaaatttgga atagatttta
    10441 gagagaagta taataagcaa atagaaatgc tattagctag aaagcttata aatcagagct
    10501 ttgaaggtat acaattaact caaaaaggaa gagaaatatc taatagtgta tttatagaat
    10561 ttatggaata atttttaagg tgttgacaaa ataaatttat aatggtatat aatatatata
    10621 atctttttag cactcgaact tagtgagtgc taacagctag gaggtataat aatatggaat
    10681 taaatgaaag aaaattaaat atcctcaaag ctatagttaa agattatata gaaacagctg
    10741 aagctatagg ttctagaaca atatctaaaa gacatgattt aggtgttagt gctgctacca
    10801 taagaaatga aatggctgac cttgaagaat tagggtattt aattcagcct catacttctg
    10861 cgggtagagt tccatctgaa aaaggctata agttatatgt aaactctctt atgagtaaaa
    10921 gcgaattgga tgataatgat aagattctta ttgaacaatg tatgaatcac aatataaatc
    10981 atataaaaga attgattcat gaaacttcta agctattatc gcaactaaca aactatacaa
    11041 ctgtagcagt tactaagagt ttaataaatc aaagtgttat aaagcacata cagttggttg
    11101 ctatgaatga caataatatt ttacttatag ttgtaacaga taaaggggac ttaaaaaaag
    11161 ctaaccttac aactaatgta tatttagatc aatctaagtt aaatttgatt tctgataatc
    11221 ttacaaggaa gctcttaggt aaaagtataa cagatttgga tgataatcta attgctttta
    11281 ttaaatacga aataagtgag tattctgggc ttatagatga gcttttaaat gctttgaact
    11341 caaatatgaa agaagaagat ttttctctat cattaaatgg agctactaac atatttagtt
    11401 atccagaatt taatgatgta ttaaaagcaa agtcattttt aaatatgttg gaaaaaaagg
    11461 aaacaatagc tgacataatt aaatcaaagg gaatacaaaa agacaatcta aatataataa
    11521 ttggtagtga taatgattgt gaactggcac aggattgtag tatagttaca gcaacttata
    11581 atgtagatag agacttggtt gggcgaataa gctttatagg ccctaccaga atggattatg
    11641 ctagaattta ctctataata aattatatga gtttattaat taatagaaag taaagaaatt
    11701 ttaaattgcg aggtgtaaag tcttggataa aaaaaatgag caacaggaag taagagaaga
    11761 aaatgatact tctattaacc aagaatcgga aactcaagta gagttagaag aggaagttgt
    11821 taatgaagaa tgtgaaacat caagtgaaaa aactgatgaa aaagaagttg atgatgaaaa
    11881 tgtaacagat ataaattcta agttagcaga aaaaaaattg caggatgagt tggatgaatt
    11941 aaatgataaa tatcaaagac ttcaagccga atatgcaaac tacagaagaa gaactcaaca
    12001 agagaaagag acaataggcg tatttgcaaa tgaaaaaata ataactgaat tgataccagt
    12061 tatagatagt atggaaagag ccttagatgc atgtgaagat aaggaagata ctatgtataa
    12121 gggtataagc cttgtacata aacaattaat agacacttta gtaaaatttg gagtagaaga
    12181 aatagaagca gaatctaagg aatttgaccc taatctacat ctagcagtta tgcaagaaag
    12241 tgtagatgga gttgaagcaa atcaaatagt aatggtactt caaaaaggat ataagctagg
    12301 aactaaagtt gtaagacctt caatggttaa agtttcttgc taagtataaa ttaaaggtta
    12361 aattatttaa cctaatataa aatattaaaa taagtaaaac ttaattatat aattactcga
    12421 ggaggatttt agtcatggga aaaataatag gaatagattt aggaacaaca aattcatgtg
    12481 ttgcagtgtt agaaggtgga gaagcacaaa taatagcaaa tagtgaaggt atgagaacta
    12541 ctccatcagt agtagcattt acaaaagatg gtgaaagaat agttggagaa cctgcaaaaa
    12601 gacaagcagt tacaaatgca gataaaacaa taacttctat aaaaactcat atgggaactg
    12661 attataaagt aaatatagat ggaaaatcat atactccaca agaaatatca gcaataatat
    12721 tacaaaaatt aaaatcagat gcagaaagtt acttaggaca aacagtaaca gaagcagtta
    12781 taacagtacc agcttacttt acagatgctc aaagacaagc aactaaagat gctggtagaa
    12841 tagcagggct tgatgttaag agaataataa atgagccaac agcagcagct cttgcttatg
    12901 gtatggataa attagaccaa gaaaagaaaa tattagtatt tgacttaggt ggaggaactt
    12961 ttgacgtatc tatacttgaa ataggagatg gaacttttga agttttagct acagctggta
    13021 acaatagatt aggtggagat gactttgacc aaatagtaat agattattta gcagaggaat
    13081 ttaaaaaagc tgaaggtgta gatttaagaa atgataaaat ggctcttcaa agattaaaag
    13141 aagcagcaga aaaggctaag aaagaattat catcaacaat gagttcaaac ataaacttac
    13201 ctttcataac tgctacagca gaaggaccaa aacacttaaa tatagattta tcaagagcta
    13261 aatttgaaga attaactaga ggtttagttg aaaaaactat ggaaccaact aagacagctt
    13321 tacaagatgc aggactttct acaggtgata tagatgatgt attattagta ggtggttcta
    13381 caagaatacc agcagtacaa gaagctgtta agaagtttat aggaaaagaa cctcataaag
    13441 gtataaaccc agatgagtgt gttgcagcag gtgcttctat acaagctgga gttttagcag
    13501 gggatgttaa agacttatta ttactagatg ttactccatt atctcttggt atagaaacta
    13561 tgggtaatgt aatgactaag ataatagaaa gaaatactac aataccaact aagaagtctc
    13621 aaatattctc aactgctgct gataaccaaa cagctgttga tatacatgtt cttcaaggtg
    13681 aaagaagtat ggcttatgac aatacaactt taggaagatt ccaattaaca gatataccac
    13741 cagcacaaag aggaatacct caaatagaag ttacttttga tatagatgca aatggtatag
    13801 ttaatgtttc agctaaagat ttaggtacag gaaaagagca aaaaataact ataacatcaa
    13861 acactaattt atcagaatca gaaatagagc aaaagataaa agaagcagaa atgaatgcag
    13921 aagctgacaa acaaaagaaa gaaaaaatag aagcattcaa tcaagctgaa tctactatat
    13981 atcaaactga aaaaacttta aatgaacttg gagataaaat aagttcaggt gaaaaagagg
    14041 atatagaaaa agctatagca gacttaaaag ctgtaaaaga taatcaagat gctacagcag
    14101 aagaacttaa gaaagctaca gatgaagtaa tgactaagtt ccaaaaagta tctcaagaaa
    14161 tgtaccaaaa agcagctcaa gaacaacaag cggcacaagg tgcagaacaa gcacaagaca
    14221 atggacctaa agatgacaat gtagtagatg ctgactttaa agaagtagat gaagataaat
    14281 aagctatata atatgtaaca ctaaatgata attggaacat atatgatttg tgaaaatcat
    14341 atagatgtta aagatatatg gacaatatac atcataaaga atataatata tcatagatta
    14401 tataacttaa agtagaatat aagaattaat gatagcttgt agtttattat tctacaagct
    14461 atcgttttgt aaaatgaagg tggtgtcaat ttttgagtac aaaaagggat tattatgaag
    14521 tcttaggtat cagtaaaggt gcagaagctc aagagataaa aaaagcttat agaaaattag
    14581 caatgaagta ccatccagat agaaatcctg gagataaaga ggcggaagaa aaatttaaag
    14641 agataaatga agcttatgaa gttctatctg atgatacaaa gagaaaaact tatgaccagt
    14701 ttggacatga tgggctaaat ggtcaaggcg gttttggtgg tcaaggagga tttggcggtc
    14761 aaggctttgg tggttttgaa gatatgttcg gagatatatt tggtgacatg tttggaggaa
    14821 gcttcggagg tggaagagca agaagaagag ggcctcaacg tggtgcagat ataagacaga
    14881 gtgttactat atcttttgaa gaagctgcat ttggtaaaaa gatgtctata aaagtaaata
    14941 gaagtgaaga atgtgaagaa tgtaatggaa ctggagcaaa accaggaaca tcaaagaaaa
    15001 cttgttcaac ttgtaatgga actggtcaag ttagaactgt tcaaagaact ccatttggta
    15061 atatagcaag ttcaagacca tgtagtgctt gtaatggaac tggagaagtg attgaatctc
    15121 catgtagtaa atgtcatgga actggaaata caagaaaagt taagactata gaagtagata
    15181 tacctgctgg tatagatgat ggtcaaatga taaaactttc tggtcaaggt gaagtaggag
    15241 aaaaaggtgc tccaagagga gacttatata ttgtagttaa tgttaagtca catccactat
    15301 ttactagaga tggaaatgat atttattttg aaatgccaat tacatttgtt caagcaactt
    15361 taggtgatga gatagaagta cctactttgg atggaaaagt taaatatagt gtgccagagg
    15421 ggacacaaac tggaactgta tttagactta aagagaaagg aatccctaga attagaggta
    15481 attcaagagg agaccaatat gttaaggttg tagttgaaat tcctaaaaaa ttaaacgata
    15541 agcaaaaaga actattgaga gaatttgcga aggagtgtgg gtcgaacgtc cacgaaaaga
    15601 agaaaacctt cggacaaaag atagaagata tgtttaagaa aaagtagtta aagtagccaa
    15661 tatataatca tatttttaaa atcttagtta tttataagat tgtcaaagga gatattatga
    15721 tttttatatt ggctattttt gtataaaaaa taaatgtgca taaaataaaa ctgaatataa
    15781 ataattttct gaaaaatact tgtcctaaaa tatataatat gctataatat aatcaaataa
    15841 aagaaagggg tgattccagt gggaacggat gtggcactgc caaatgatga agaaaacttt
    15901 attgtaatat acaaaataaa attagatact tttagtgcta gattaagtac tggaaaaact
    15961 catgagctgg gataattatt gtaattacct agactcaaac ttttagtagt aaaatagtaa
    16021 tattatatag acaaggtatc taatttttaa atcttttgta tgaattaaaa tttttataaa
    16081 gggtatatct gattagaatg taattaggga aacctagttg tgaattactt ttagtatata
    16141 catgtgtaaa gaaatatgta tatggtattg ggtattgtgc tagatgtgta tgtaaaggaa
    16201 tatgtgtcta gttgggtata tgtaaagaaa tatacttata atctatgaaa aatttttagt
    16261 ataaattgct aaaacattga gattgttttt tatagaaagt tagtttatac caactaaaaa
    16321 tgtgcttaag atttgtttga tgtttaatta taaataaggt tgtagataaa aaaataagta
    16381 aagacaaagg tttaaaatac ttgctttaaa tatagtttgt tttgaacact tgccaaatta
    16441 aaataattaa taaaatagac atcttctcat agtaaaatat actgtgagag gatgtttttg
    16501 ctttgttcat aaacttttat gaaaaatttg catagtgtca cattttaata tactatatat
    16561 ataataaaat atagataaaa ttaaatgatt caaaagagaa aggtgaaaag agatgtatta
    16621 tataggtgta gacataggag gaacaggtat acaagcagga gtagttgata actatgggaa
    16681 gataattttt aggtcagagt gtaaaacagt aattgaaaaa ggatttgaag gaatacttaa
    16741 tgacataaaa ataatgattt ataagttgtt ggaagataat aaacttacta tgagtgacat
    16801 aaaatctatt ggatttggtg ttccaggttt tataaataaa gaaggattag taacttgtgt
    16861 aaatttaaaa tggaataaaa aagcttttaa taaagagtta aaaaaaagat ttccagatgt
    16921 tgaaattcat ggagaaaatg atgcaacagt agcagcactt ggagaagcaa agtttggaag
    16981 tatgaaaggt gctaatgttg gagtattata tactttagga actggtgtag gtggaggaat
    17041 agtaattaat caaaaagtct tttctggagc acatggattg ggttcagaaa taggtcatca
    17101 aattatagga gaaaactatt ttaattgtaa ttgtggaaat aatggttgtg tagaaacttt
    17161 ttgttcagca actgcaatta taaagtattc tcaaaaactg atagaagaag gagaaaagag
    17221 taggatttta gatttggcag agggaaattt agaaaatgta aatgcaaaga tggtgtttga
    17281 tgcatataga gaaaatgatt tagtggcaat taaagtaata aatagattta aagagtattt
    17341 agcaaaaact tttgcaaaca caataaattc tttagaccca gaaattatat ctataggagg
    17401 aggcatttct aaatctagcg atataatact tgatggaata gaaggtttgg taagaaaatt
    17461 tgtattatac aaaacagaag atatagctac aattacatgt gcaactttag gttcagacgc
    17521 aggaattata ggagcagctt ttttataatg taaatgaact gcttattgga ggcgtgatga
    17581 tatatgggta aaacaaatgc tagaagaacg ctttttttga tagcaatagg ttcaggaact
    17641 atgctgaatc ctcttaattc ttctatgatt tcacttgctt tacatagtat acaaaatgat
    17701 tttcatatta gttttacaac tgtatcttgg attgtttcag cattttacct agctagtgct
    17761 attgcacaac cagtttcagg taagatagga gatttaatag gtagaaaggt cttatttttg
    17821 agtggtttga tgcttgtaat tttatcagca tccatagtac cacttgttca atcattcttt
    17881 atattgattt ttataagagt aattcaagca attggaacaa gtaccctata tccatctgga
    17941 gttgctctta tacaaaataa tataaaagaa agacaatctt ctgcattagc agttctaacc
    18001 atttttgctt caactacagc aggattaggt ccgacacttg gaggattatt gttggactta
    18061 ggaggatggc atgctatatt tcttgtaaat atacctgttg ttttggtttc tatatgctta
    18121 gggtattttt tattcccaaa agaagtaaaa gaaaagaaat ctataaaaga aactttaaaa
    18181 aatgttttgt caagattaga tattattggc atacttctat tttcaattgc aatgattttt
    18241 atattactat ttttgctatc tatgaaggaa tcttttaact tagaacaact tgtatttggt
    18301 ataatactga tgtgtctttt tatttggcat gaattgagaa caaaattgcc atttatagat
    18361 attaagcttt ttgtaagtaa tcctaaattg tcaaaagttt acttgcaatt tattatatta
    18421 aatttcttta attatatttt gttttttggt cttcctagtt attttcaaga tgccttacat
    18481 tatagtgcaa agtcgactgg attatttatg ctatttatgt ctggtatagg tatatttata
    18541 tctccattaa ctggaaaatg gatagataaa tctggaacta gatttcctct tgttacatca
    18601 tcaatcttta tgtttattag tgcagtactt ctttcagtag tttttatcca tatacctgta
    18661 ataggaaagg gtattatatt atcattagca ggtattagtt atggagttgg taatgtagcc
    18721 ctgcaatcct ctatgtttga agaaagtcct cgtgacagta tagggacagc ttctggtctg
    18781 tttcaaacta gtcgttattt aggttctatt ttagcaactg ttttacttgg aatggtattt
    18841 gaagtaaata taacatcaga acaatttcag atattaggtt atgttatggt ggtcttaggt
    18901 acaataagtt ttttattaaa ttttatatta aagaaagaat taagaaaagt agaatagtgg
    18961 atttatggat ttaataagtc taataactga taagtttaaa aatattgttt gtaaaacata
    19021 actggtttga tatttattaa ttctaagttt tgaagcatag agtactcgat aagtatacaa
    19081 tattttgaat taaaattaag cagaaatttg aactagtctt tcaaatctct gcttaattta
    19141 gtagttaaat ttttttatag agaaaataag atttgacact tagataaaaa atcatt
//
LOCUS       DAEPID010000075        19017 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.075, whole genome shotgun sequence.
ACCESSION   DAEPID010000075 DAEPID010000000
VERSION     DAEPID010000075.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 19017)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 19017)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..19017
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.075"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            complement(361..738)
                     /locus_tag="KR257_002965"
     CDS             complement(361..738)
                     /locus_tag="KR257_002965"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423847.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="BlaI/MecI/CopY family transcriptional regulator"
                     /protein_id="HBH0031637.1"
                     /translation="MTISKIPQAELKVMKFIWEKNDTVTSKETIEAMERKYGWKQTTT
                     LTLLSRLVKKHFLSAEKIDRYTHYTIVVGHKEYLSVETKDFLSNIHDNSLQSLISALH
                     DDEVVDKDMLDLFESHFKNLEEE"
     gene            complement(925..1896)
                     /locus_tag="KR257_002966"
     CDS             complement(925..1896)
                     /locus_tag="KR257_002966"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430314.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MFS transporter"
                     /protein_id="HBH0031638.1"
                     /translation="MLLRASIGMGIVIFTMAFVQNVYQLLGLRILQGVFTGYATACTT
                     LIATQTDKNHSGWALGTLATASTTGSLIGPTVGGYIESILGLKSTFIITGGLLFVSFI
                     ISILFVVDNFKPKEIKESISIPKEQLNILPNKFLIASIFVTTFITQLALYSIEPIVTI
                     YISQLTNFASNVALIAGLTFSASGLANLLAAQKLGKMSDKIGPQKVLLISLLWAGIIF
                     IPQAFVKTAWQLMLLRFLLGLSVAGLNPSVNSLLKKIAPEEYVGKIFGYNASAQYIGC
                     SSGAFLGGQISAHLGIRTVFFSTSLLLFRNALWMYKFTGLFIKDKTK"
     gene            complement(1930..2127)
                     /locus_tag="KR257_002967"
     CDS             complement(1930..2127)
                     /locus_tag="KR257_002967"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423835.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="multidrug transporter"
                     /protein_id="HBH0031639.1"
                     /translation="MELWKRNLFVCWIGMFFSSIGMSQIAPILPLYIKQLGVTDVSLI
                     QQYSGIIFGCTFVVAAFFSPI"
     gene            complement(2195..3406)
                     /locus_tag="KR257_002968"
     CDS             complement(2195..3406)
                     /locus_tag="KR257_002968"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861341.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pyridoxal-dependent decarboxylase"
                     /protein_id="HBH0031640.1"
                     /translation="MYSNEDYKFIEENAPCYIYDETNIIEKCKELKNNILGFDFLYSI
                     KTNPYNKIVKSIAEQGFGADASSTNEVMISSKCGVSKDDIYYSSPGKTEIDIETVLDK
                     CIIIADSITEIELINKISKKHNQKVKIGIRINPDFTMDDDSAKSSKFGIDIEDMSSVF
                     KMLSMCDYVSVVGIHIHIKSQVLDFEKLGHYYEKCFFIALNLNKSKYINIEFINFGSG
                     LGVAYDNLRENPLNLKELSKLTQKIAFTNSNTLKSRLLIESGRFIVCKSGNYYVKIVD
                     IKVSRGKKYLIVKNGLNGFMRPIISNLIENITCGVELEGQEPLYTSNHAFSLSVLNNL
                     KEEEYVNVVGNLCTSLDVIANNVKLKKANIGDLISISNAGSYSYSLSPLLFSSYEFPK
                     QYYKRKDGYIE"
     gene            3687..4289
                     /locus_tag="KR257_002969"
     CDS             3687..4289
                     /locus_tag="KR257_002969"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430312.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flavodoxin family protein"
                     /protein_id="HBH0031641.1"
                     /translation="MEVCILMGSPKKKGNTAAILKPFIEELENYNSNIEVIWLYDCKI
                     EPCIACKKCQDNLFDFGCYCKDDVQKIFKKILMCDLIVFATPIYSWYCTSPMKALLDR
                     LVYGMNKYYGNEKGPALWAGKSVALITTCGYRPEKGADIWENGMKRYCKHSQLKYIGM
                     LVERDLGKPNFMNKEKEEHSRQFAKQIYYILSNSIELDNC"
     gene            complement(4545..5516)
                     /locus_tag="KR257_002970"
     CDS             complement(4545..5516)
                     /locus_tag="KR257_002970"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423829.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="carbohydrate kinase"
                     /protein_id="HBH0031642.1"
                     /translation="MKKVISIGEALIDFIPNQNGGKLKNVSEFRRVAGGAPANVSAVV
                     AKLGGKSSFISKLGKDAFGDYIIDVLNEVNVNTDYVLRTSKANTGLAFVSLKEDGNRD
                     FSFYRNPSADMLLEADEVKKEWFNNCHILHFCSVDLIDSPMKLAHKKAIEYALESNSI
                     ISFDPNIRLPLWDSEQSCKKAISEFLPFAHIVKISDEELEFITGENDIEKSLHKLFVG
                     NVELVLYTKGKDGVDAYTKKVKGMCKGVKVNAIDTTGAGDSYIGSFLYTLLYKQITLN
                     DIKEMKQETLNEYLEFSNYYAARSTTIKGAISSYATKEEITEFIKNL"
     gene            complement(5542..7023)
                     /locus_tag="KR257_002971"
     CDS             complement(5542..7023)
                     /locus_tag="KR257_002971"
                     /EC_number="3.2.1.26"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896953.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sucrose-6-phosphate hydrolase"
                     /protein_id="HBH0031643.1"
                     /translation="MYKEPKYRTILESTKEELNKLRNISLNDKYKPLFHIHPQHGLLN
                     DPNGLAYYNGKYHVFYQWYPYDATHGMKHWAYVSSDDFVNWNREDVALIPIESYESHG
                     AYSGNAIEVDGKLHMYYTGNIKYSAEDRYAYQNLAIMNKDGKITKYENNPIVSEIPKG
                     YTGHVRDPKVFKRKDKYFMLLGAQTSDKKGVIIVYESKNSIDWNFKGELNVKNIDEDF
                     GYMWECPDYINIDEKDILIFSPQGVEPKGFDYQNIYNVVYAIGNMDLDNLTFEIDTMK
                     ELEKGFDFYAPQTFIKDSQIILFAWAGMGEVLYPTDKNKWAHCLTVPRKLNIKNNKLL
                     QMPVDELIKLRYDETSGQNTIKNNINIIENDENVYELNINIKNIDSNKFGLELFSSQD
                     EGVKLEFNKLGNIVTLDRSNFKKVFGVEYGTNRKEYINIDENTNIKVLADRSILEIFI
                     NEGEVVFTSRIFAKENSNQIRVYSDKIVEYEYTKFKLKQGIEL"
     gene            complement(7042..7190)
                     /locus_tag="KR257_002972"
                     /pseudo
     CDS             complement(7042..7190)
                     /locus_tag="KR257_002972"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423822.1"
                     /note="frameshifted; internal stop; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="PTS transporter subunit EIIB"
     gene            complement(7359..8345)
                     /locus_tag="KR257_002973"
     CDS             complement(7359..8345)
                     /locus_tag="KR257_002973"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902777.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LacI family DNA-binding transcriptional
                     regulator"
                     /protein_id="HBH0031644.1"
                     /translation="MKKITINDIANLAGVSKSTVSRYLNNKDISDSTKEKIKTIIDEY
                     GYEPNAFAQSLRAKKTYFIGIITPCLDSFVKSKIMMAIDEELKKLKYTSLIINTNRKI
                     RSEIDSISKLASLKVDGIILIGTEITKEHKNEIEKLDIPIVVVGQKVDGINSIVNDDY
                     GAGYKMGQYIANKGYKNIVYLGVDESDISVGLNRKNGVLNGLKDKGYDAKVFYTDFDQ
                     EMSIQRSGEMLESENPDIIICATDNIAIATMKEINKRGKSIPQDISVAGFGGYDVLSI
                     ISPKLTTIKFENKNAGKVAANTIVNLIQERKEPLLKEIKFELIEGESTINKN"
     gene            complement(8729..10483)
                     /locus_tag="KR257_002974"
     CDS             complement(8729..10483)
                     /locus_tag="KR257_002974"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861339.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell wall-binding protein Cwp23"
                     /protein_id="HBH0031645.1"
                     /translation="MYIMNKKFKKFSKKLSILILVLTMFLFNNLTANAQIKEDSIIGI
                     DRYETAGLIADRQTYDTVILVNGDKNLSDGLSSSGLAGAINAPILLTKKSEIPKATLN
                     RLDNKSLNVVKKVYIIGGYNTIENSVEKDIKRKGIQVERINGNNRIETSYNVAKKINE
                     VSSVKEVMLTNGFVGEADAMSIAPVVAKNKGAIILTDGKSVPFKTEGLNVYAIGGKSA
                     INEDLVNETKAIRIGGNDRFETNKKVMEKFYNGATDFYITNGYQLVDALTLSPLAKEK
                     PIVLVADGSNKGILKGAKSITKVGGIDANIYKQCLDMIKYNNMDMTPNILKHLTSVEG
                     NEVSEILIESDNLGVVVEKTNTNKFEFDYVSVTNEKNCTFSVYKENSSNNIKNGKLVV
                     SAKKKIDKKDSDLQDMNGDNMINANKDRMVNVIKIGVPDKMYSNFKVDVESGSVELYN
                     IKGGATVDVNDGIANIVDNNVTNPFNINTNSGISGVTAETISSEIKFRANNGIVNVTA
                     TNINGNISLFGSDNKDTFDGIFKLNLKKEPSNLHLKLIGNGINKLPEGWSKDYILGNG
                     QPIIEVKNNGINNISIGE"
     gene            complement(10701..11591)
                     /locus_tag="KR257_002975"
     CDS             complement(10701..11591)
                     /locus_tag="KR257_002975"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889757.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MBL fold metallo-hydrolase"
                     /protein_id="HBH0031646.1"
                     /translation="MAKLTLEHIKGNTYYIPLPTIVGVYVDGKDAILIDSGNNKDTAR
                     QVLRLLEEHNLNPKLIINTHSNADHIGGNAYLKNQTKCKIATTKIEGYFTENPILESA
                     FLYGGYPSKALKNKFLLAKESEVDYIIPSNGKIVDTELEAISLPGHYFEMIGVRTPDN
                     VLFVADSLTPENIITKYHFFFLLDIDSQFKTLEKLRMLEADFFVPSHSVKTTDIKSLI
                     NINKKKMEEIIDNIKKVCYEPVMIDEVIEKMCDLYNVKLDANQYVLVGSTIRSYITYL
                     YENNMVEYIFDGGKMMIKAA"
     gene            11740..12600
                     /locus_tag="KR257_002976"
     CDS             11740..12600
                     /locus_tag="KR257_002976"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430304.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YitT family protein"
                     /protein_id="HBH0031647.1"
                     /translation="MLLKKDRITFSEILILIVGCILMAISLNLFFNPHAIAAGGITGL
                     GVVLNSLFGVELWIVNLLLNVPLFIFAYKILSKKDCFKTVLGIIFLTIALKLTANMAT
                     LDITNDMYLAIISGSILMGVGQGLIFRINGSTGGTDLMALLLNKYFPTFSIPVLMGIV
                     DCVVVVLSGIVNRQVEIALYSTVALYILVKVSDLLIEGFNYSKSFTIISDLSKDISKK
                     IMEDLDRGATILKGEGAYTGENKNVLLVVVEKKEVVELKKLVKNVDPNAFIIITDIHE
                     ALGNGFKKIE"
     gene            13056..13622
                     /locus_tag="KR257_002977"
     CDS             13056..13622
                     /locus_tag="KR257_002977"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728615.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TerD family protein"
                     /protein_id="HBH0031648.1"
                     /translation="MSVSLQKGQRVSLVKDNNPVKNLVVGLGWDMNKLGKKNYDLDAF
                     AIALTNQDKMNVRGDLVYFGNLKHPSKAIIHTGDNLTGKGEGDDEQIIVNLEDIPEYV
                     HKIVFGVSIYKAKKRDQDFGQMNNSFIRLIDSNSKQELFKYNLQEDFSGKVTVLAGEI
                     YRRNEEWKFNALGIGQNEELRELINTYK"
     gene            13662..14243
                     /locus_tag="KR257_002978"
     CDS             13662..14243
                     /locus_tag="KR257_002978"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430302.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TerD family protein"
                     /protein_id="HBH0031649.1"
                     /translation="MGITLAKGQKVSLTKSNPGLKKVIVGLGWDINKYDGGFDFDLDA
                     SAFLTGTDGKVTNDGDFIFYNNLKHASGAVEYMGDNRTGVGDGDDEQINVDLSKIPQN
                     IAKISFSVTINEAITRRQNFGQVENSYIRIYNEETNEELIKYELGEDFSIETAIVVAE
                     LYRHNGEWKFNALGSGFEDGLAGLCKNFGVNIG"
     gene            complement(14300..15217)
                     /locus_tag="KR257_002979"
     CDS             complement(14300..15217)
                     /locus_tag="KR257_002979"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423804.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LysR family transcriptional regulator"
                     /protein_id="HBH0031650.1"
                     /translation="MTIRSLEIFVKVAECGKMSEVARNMYITQSSVSQAISEIEKEYG
                     VKLFDRISKKLYLTEAGKKLLGYGRHLLAVNEEMNDCMKHCAKNIRIRVGATVTVGTC
                     VISPIMLELYKVNPLIEPEVFVEDTRLIAKKLLNSELDIAIVEGKIKHPDIVTKSIIN
                     DNLVLICSHKHEFYKRDSIKVSELSNQPLIMRELGSGTRAQLEKQLKELKIPMNIRWS
                     CYNSEAILRAVVDNFGIAVISELLIEDYLKKHLLWACDIEGINLHRTFDIAYHRSKFF
                     TENISAFFDISVEYGKKQARKKSRSVNSL"
     gene            15347..16978
                     /locus_tag="KR257_002980"
     CDS             15347..16978
                     /locus_tag="KR257_002980"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896946.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="FAD-dependent oxidoreductase"
                     /protein_id="HBH0031651.1"
                     /translation="MKVLIIGGVAAGTKTAAKIKREMGDNCSVTILNKGDDISYAGCG
                     LPYYVGKIIEDKSSLIVNTPESFSKLTGAEVRCGVEVTSIDRNAKQVTLKTLSTGEKE
                     NLSYDKLVIATGADPIKPPIPGIDLPGVFFVRTPNDAIKLRDSIENGIKRAVVIGGGF
                     IGLEIAENLSAMGIRVSVVDMAEHVMPGFDTDFAEYVENHMADKGIMIFTGDQVVGIE
                     GENKVEKLRTKNRAIKTDLVVMSVGIRPNTGFLKDTGLEFAPNNTIIADEYMLTNDKD
                     IYVVGDCAFVKNSLTNKPTWSPMGSSANHEGRICAQNISGKSKTYNGVLGTTVVKLPE
                     LNAGKTGLSKEIAEKEGYNVCSVTIATDDKAHYYPGASNFIIRMVAEKNTRKLLGVQV
                     MGPGAVDKIVDIAATAITLGADLYSLESMDLAYAPPFSTAIHPFVVAVNVLQNKLNGE
                     LDSVLLDEIEDFDSWTKLDVSKAPSIPSLRYIPVGEINGEIEGLAKDEKILLICAKGK
                     NSYMAQNRLRRFGYTNTKVLEGGILFYPNLKVMEE"
     gene            16981..17928
                     /locus_tag="KR257_002981"
     CDS             16981..17928
                     /locus_tag="KR257_002981"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013378669.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="(4Fe-4S)-binding protein"
                     /protein_id="HBH0031652.1"
                     /translation="MSNVTAEQKKEVKGRGFLPSRDGEHFAARIITVNGVINASQAKK
                     IAEAAEKFGNGQLAFTTRLTVELPGVKFEDIEALSEFIASENLITGGTGSRVRPVVAC
                     KGTVCVHGLADTQALAAEIHEEFYKNWYDVKLPHKFKIGVGGCPNNCIKPDLNDLGIV
                     GQRVPDYDSELCVGCKKCAVVEVCPVKAAKLTDKGKLEIDSNLCNNCGKCIESCNFDS
                     IEEKESGYKVYIGGKWGKSVRPGTQIDRLFSKEELMTLIEKAILLFREQGNTGERFGI
                     TIDRIGADKFIEMLLSDEVLERKEEILEALLHLTGGAVC"
     gene            complement(18213..18476)
                     /locus_tag="KR257_002982"
     CDS             complement(18213..18476)
                     /locus_tag="KR257_002982"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430298.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1883 domain-containing protein"
                     /protein_id="HBH0031653.1"
                     /translation="MEYSYSKMNLKKGDIVEVNLEKQANVILLDHINYVKFKNQRNYD
                     YYGGFAKKNPCRMRVPNTGTWYLVVNQDGNSGIVNFSINTIQN"
     gene            complement(18575..18820)
                     /locus_tag="KR257_002983"
     CDS             complement(18575..18820)
                     /locus_tag="KR257_002983"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423796.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0031654.1"
                     /translation="MFIDEELEGYILTCKISEDFKNIPEYSDEEFYVTVYKDESSDSG
                     YYALLENKEERVVWDGEVVANNIFNNLWIVINKVKTG"
BASE COUNT         6481 a         2856 c         2322 g         7358 t
ORIGIN      
        1 agtttaaaaa tataaaaatc atttcttact tttagtttac ctataataac aaaagacagg
       61 tttatattgt aataattaaa aatagtaaaa tatattttga tatggttaaa tagaaataat
      121 actttagatt aatgaatatt gacaagttat aaaattattt taaattttaa aaatcatttc
      181 ttatttaaat aagtggtatc atttaacttg atactcccta ttccaattat tttaggcatt
      241 ttactaatta gagaacctat ttaatattac tttatgaata gtgagtagct gattaaataa
      301 taccatttat ggttttcagc catagattaa ttaaattctt agagttctat cctgatataa
      361 ttactcttct tctaaatttt taaaatgact ttcaaataaa tccaacatat ctttatcaac
      421 aacttcatca tcatgtagtg ctgaaattaa actctgtaaa gaattgtcgt gtatattgct
      481 taaaaaatct tttgtctcaa cacttaaata ctccttatgt ccaacaacta ttgtataatg
      541 agtgtatcta tctatttttt ctgcacttaa aaaatgtttt ttaacaagtc ttgataaaag
      601 tgtcaatgta gttgtttgtt tccaaccata ttttcgttcc atagcttcaa tagtttcttt
      661 tgatgttact gtatcatttt tttcccaaat aaacttcata acttttaatt ctgcttgtgg
      721 tatttttgaa attgtcataa ccttacgccc ctctcaaact tttattaaat taatactatc
      781 gcaatatagt ttttaagtca aagattttgt cgataataat attttccaat ttttaccata
      841 gggttatttt ttatataatt ctatgataaa ttacataaaa aatatttatt ttacatcata
      901 aaattagaaa tgtaaatagt atgattattt agtcttatct ttaataaaca atccagtaaa
      961 tttatacatc caaagtgcat tcctaaacaa caataaactt gttgaaaaaa atactgttct
     1021 aatacctaaa tgtgctgata tttgtccccc taaaaatgct cctgatgaac agcctatata
     1081 ctgggcagat gcattatatc caaatatttt tcccacatat tcttctggtg caattttttt
     1141 aagcaagctg ttaacagaag gattaagccc tgcaactgac aaccctaata aaaatctcaa
     1201 caacatcagt tgccatgcag tttttacaaa agcttgtggt ataaatataa tcccagccca
     1261 taaaagtgaa attaacaata ctttttgagg acctatttta tccgacattt ttccaagttt
     1321 ttgagctgct aataaatttg ctaatcctga tgcagaaaat gtcaatccag ctattaaagc
     1381 tacatttgat gcaaaatttg taagttgtga tatatatatg gttacaattg gttctataga
     1441 gtataaagct agttgagtaa tgaatgtggt tacaaaaata gatgcaatta aaaatttatt
     1501 tggcaatata tttaattgtt ctttaggtat agaaattgat tcttttattt ctttaggttt
     1561 aaaattatct actacaaata aaatagagat gataaatgat acaaacaaca atcctcctgt
     1621 tataataaat gtacttttaa gacctaagat tgattctata tatcctccta ctgttggacc
     1681 aattaatgag ccagtagttg atgcagttgc aagagtaccc aaagcccatc ctgaatgatt
     1741 tttatctgtc tgtgttgcaa taagagtagt acatgcagta gcataacccg taaaaactcc
     1801 ttgaagtatt cttaatccta ataactgata aacattttga acaaacgcca tggtaaatat
     1861 aactattccc atcccaatac ttgcacgtaa aagcattgat tttcttccat atttatcagc
     1921 agctttccct caaattggcg aaaagaatgc tgctactaca aaggtacatc caaaaattat
     1981 acctgaatac tgttgtatta aactaacatc agttaccccc aactgtttaa tatataatgg
     2041 aagtataggt gctatttggc tcatccctat agaactaaaa aacataccta tccaacatac
     2101 aaataaattt cttttccaca attccatata gaattacacc ccctgcattt taaatttttt
     2161 caataatact aagtttatta atttatgcta ttgtttactc aatatatcca tcttttcttt
     2221 tataatattg tttaggaaat tcataacttg aaaataatag cggtgataaa gaataggagt
     2281 aacttccagc attactaatt gaaatcaaat ctcctatgtt tgcttttttc aatttaacat
     2341 tatttgcaat tacatctaat gatgtacaga gattcccaac aacatttaca tactcttctt
     2401 cttttaaatt atttaatact gaaagagaaa aggcatgatt tgatgtatat aatggctctt
     2461 gaccttctaa ttctactcca caagtaatat tttcaattaa attagaaata ataggtctca
     2521 taaatccatt aagtccattt tttacaataa gatatttttt ccctcttgat actttaatat
     2581 ctacaatttt aacataataa ttacctgatt tacaaactat gaaacgtcct gattcaataa
     2641 gaagtcttga ttttagtgtg tttgaattag taaaagcaat cttttgagtt aattttgaaa
     2701 gctctttaag attaagtgga ttttctctaa gattatcata agctactcca agtccactac
     2761 caaaatttat aaattcaata ttaatatact tacttttatt taaatttaaa gctataaaaa
     2821 aacatttttc ataataatgt cctaactttt caaaatccaa tacctgagat ttaatatgta
     2881 tatgaatccc aactacagat acataatcac acatacttaa catcttaaaa acactgctca
     2941 tatcttctat atctatacca aatttgcttg atttagcact atcatcatcc atagtaaaat
     3001 caggatttat tcttattcct attttaactt tctgattatg ctttttagat atcttattta
     3061 taagttctat ttctgtaata ctatctgcaa taattatgca tttatctaaa acagtttcta
     3121 tatcaatctc tgttttgcct ggtgatgaat aataaatatc atctttagaa actccacatt
     3181 ttgatgaaat cataacttca ttagttgaag aagcatctgc tccaaaacct tgctctgcaa
     3241 tgctttttac aattttgtta tatggatttg tttttataga atataaaaaa tcaaaaccta
     3301 aaatattatt tttcaattcc ttacattttt caattatatt agtctcatca tatatataac
     3361 atggtgcatt ttcttctata aatttatagt cttcatttga gtacatattt tttacctcca
     3421 agattttaaa tataatcata aattaagcaa ttataatcct ataagataat tttacaataa
     3481 attaccatag ttaactacac acatatatgt aaaaacatac ctaaaatatt tttaattata
     3541 gatacattcc aacttttatt gataaaacaa tttgtttcaa ttttattaca aatatacaaa
     3601 gtgtattgtt gttaacgtat tctcatagta tcctaaaact atattaagca ctaaaaacta
     3661 ttttaaaata ctgtggaggt atcaatatgg aagtatgcat tcttatggga agtcctaaga
     3721 aaaaaggtaa tactgctgct attttaaaac cttttattga ggaattagaa aattataatt
     3781 caaatattga agtaatatgg ttatatgatt gtaaaataga gccatgtatt gcttgtaaaa
     3841 agtgtcagga taacttattt gattttggat gttattgtaa agatgatgtt cagaaaattt
     3901 tcaagaaaat tcttatgtgt gatttaattg tttttgctac tccaatttat tcttggtact
     3961 gcacttctcc aatgaaagca ctacttgaca gattggtgta tggaatgaat aaatactatg
     4021 gtaatgagaa aggccccgct ctatgggcag gaaaatcagt agcacttatt acaacatgtg
     4081 gatatagacc tgaaaagggt gctgatattt gggaaaatgg tatgaagcgc tactgtaagc
     4141 attcacagtt aaaatatata ggaatgcttg ttgaacgtga tttaggtaaa cctaatttta
     4201 tgaataaaga aaaagaagaa cattctcgtc aatttgcaaa acaaatttat tatattttat
     4261 ctaattcaat tgaattagat aactgctaaa gacataatac tccaagtaaa gtattgataa
     4321 tataaataaa tcttacataa tttgcttatt taaaataaga tatatattct tctaaaaagt
     4381 aacaataatt aaaatatttt ttatcatttc aacaatgata aagaggctta tctctatttt
     4441 gagacagcct ccttattgct ttttatatgt taattatttt catagtaaac atccttaaaa
     4501 actctttaca tgttacttcc ttcaaaacct attactcatt cctactataa attttttata
     4561 aattcagtta tttcttcctt tgttgcatat gaacttatcg cacctttaat agttgtacta
     4621 cgagctgcat aataattaga aaattctaaa tactcattta acgtttcttg tttcatttct
     4681 tttatatcat tcaatgttat ttgtttatac aataaggtgt ataaaaatga acctatataa
     4741 gaatctcctg ctccggttgt atctattgca tttactttaa cccctttaca catacctttt
     4801 acttttttag tgtatgcatc tactccatct tttccttttg tatataatac tagttcaaca
     4861 ttccccacaa agagtttatg taatgatttt tctatatcat tttctcctgt tataaattct
     4921 aattcttcat cagatatctt aacaatatga gcaaaaggta aaaattctga tattgccttt
     4981 ttacaagatt gctcactatc ccataaaggt aatcttatat tagggtcaaa gcttattata
     5041 ctattacttt caagtgcgta ttctattgct tttttatgtg ctaatttcat tggactatct
     5101 attaaatcta ctgaacaaaa atgtaggata tgacaattat taaaccactc ttttttaact
     5161 tcatcagctt ctaaaagcat atctgcactt ggatttctat aaaatgagaa atcacgatta
     5221 ccatcttctt ttaatgatac aaaagcaagt cctgtatttg ctttacttgt tctcaataca
     5281 taatcagtat ttacatttac ttcatttaat acatctatta tataatcacc aaatgcatct
     5341 tttcctaact tagatataaa actcgatttt cctccaagct ttgctacaac agcactaaca
     5401 tttgctggag ctcctcctgc tactcttcta aattctgata cattttttaa tttaccacca
     5461 ttttgattag gtataaagtc tattaaagct tctcctatac taattacttt tttcatcttt
     5521 tctacccctt ataatgtgtt tttataattc aataccttgc tttaatttaa atttagtata
     5581 ctcatactct actattttat cactataaac ccttatttga ttagaatttt ctttagcaaa
     5641 tattctacta gtaaatacta cttctccttc atttataaaa atttctaaaa tacttctatc
     5701 cgctagtact ttgatattag tattttcatc aatatttata tattcttttc tatttgttcc
     5761 atattcaaca ccgaaaactt ttttaaagtt gcttctgtct aaagttacaa tgtttcctaa
     5821 tttgttaaat tctaatttta caccttcatc ttgtgatgaa aataattcca gcccaaattt
     5881 attgctgtca atatttttta tattaatatt aagctcatat acattttcat cattttctat
     5941 aatattaata ttattcttta tagtattttg cccacttgtt tcatcatatc ttaatttaat
     6001 taattcatct actggcattt gcaatagctt attatttttt atatttaatt ttcttggaac
     6061 agttagacaa tgtgcccatt tgtttttatc tgtagggtat aaaacttctc ccattccagc
     6121 ccatgcaaat agtattattt gtgagtcctt tataaatgtt tgtggagcat agaaatcaaa
     6181 tcctttttcc agttctttca ttgtatctat ttcaaatgtt aaattatcta aatccatatt
     6241 accaatagca tatactacat tatatatatt ttgataatca aatcctttag gttctactcc
     6301 ttgtggtgaa aatattaata tatctttttc atctatatta atataatctg gacattccca
     6361 catgtaacca aaatcttcat ctatgttttt tacatttaat tctcctttaa aattccaatc
     6421 tatagagttt ttagattcat atactattat aactcctttt ttatcacttg tttgtgctcc
     6481 aagtaacata aagtatttat cctttctttt aaatactttt gggtctctta catgtcctgt
     6541 atatcctttt ggtatttcac ttactattgg attattttca tatttagtta ttttaccatc
     6601 cttgttcatt atagctaagt tttgatatgc atatctatct tctgcactat attttatatt
     6661 ccctgtataa tacatatgca attttccatc tacctctatc gcattacctg aatatgctcc
     6721 atgagattca taactttcga ttggtattaa tgctacatct tctctattcc agtttacaaa
     6781 atcatcagaa cttacataag cccaatgctt cattccatga gttgcatcat atggatacca
     6841 ttgataaaat acatggtact taccattata atatgctaat ccatttgggt cattaagtag
     6901 tccatgttgt ggatgtatat gaaatagtgg tttatattta tcatttaaag atatatttct
     6961 taatttattt aattcttctt ttgtcgattc taatatggtt ctatatttag gctctttgta
     7021 catattttta ttccttttct tttataattt tatatttgct ttattattgc tatctaaaac
     7081 aattcttagt cttattacac aatgtgctac atcttttata ttttgtttat tcctatgtac
     7141 tccaataatt actttgatac tttgttacaa tcagttattt ttgcactcat tttgctattc
     7201 tatcggttta attaaaccgg tttcgaaacc ggtttaatta aagattagca taaatttatt
     7261 tcagatgcaa tatttctttc aaaaaagttt tcctaatttt tagaattata gtttttttag
     7321 taaaaaaata cacattacta atatatgtaa tgtgtatctt aatttttatt tattgtactt
     7381 tcaccttcta ttaattcaaa tttaatctcc tttaatagtg gttcttttct ttcttgtatt
     7441 aaatttacta tcgtatttgc tgctacttta cctgcatttt tattttcaaa ctttattgtt
     7501 gtaagtttag ggcttataat agacaataca tcatatcccc caaatccagc tacagatata
     7561 tcttgtggta tacttttacc tctcttattg atttctttca ttgttgctat tgctatatta
     7621 tcagttgcac atattattat atctggattt tcactttcta gcatttctcc acttctttgt
     7681 atagacattt cttggtcaaa gtcagtataa aatacttttg catcataccc tttatctttt
     7741 aacccattaa gtactccatt ttttctattt aaaccaactg atatatcact ttcatcaaca
     7801 cctaaatata caatgttttt gtaaccttta ttagcaatat attgacccat tttatagcct
     7861 gctccataat catcattcac tatgctattg ataccatcaa ctttttgtcc aactacaact
     7921 atcggtatat ctaacttttc aatttcattc ttatgttctt tagttatttc ggtaccaatt
     7981 agtattattc catcaacttt tagactagct aactttgata tactatctat ttctgacctt
     8041 atttttctat tagtattaat aattagtgat gtatatttta attttttgag ttcttcatct
     8101 attgccatca taattttaga ttttacaaaa gaatctaaac acggtgttat aataccaata
     8161 aaatatgttt ttttagctct caaactttga gcaaatgcat tcggctcata tccatattca
     8221 tctattattg tctttatttt ctctttagta gaatcactga tatctttatt gtttagatat
     8281 cttgatacag tacttttaga tactcctgcc aagttagcaa tatcatttat tgttattttt
     8341 ttcataggtt atcaccttct acatttgata tattttatta cattatatta tatatttaaa
     8401 ataaaatata gttatttgtc cagtcaatac tttttatata ctacttgtac tatccattcc
     8461 acatccaaat aattgagtct ttaacattaa attaattgta attttcattt tttgttgtta
     8521 tatttaattt caattttatc tactatgaat tgataaatac tctaatttat ttataatata
     8581 aaaataaggc tatgattttt acaaccatag ccttatcgat aaacacttaa ttatcactta
     8641 aaaaataatt ttttatttaa agaatatata taaatatttt aaaattctat aatttttaaa
     8701 actatataaa ctttattttc atatgttttt attctccaat tgatatatta tttatgccat
     8761 tatttttaac ttcaataatt ggttgtccat ttcctaaaat ataatcttta gaccaacctt
     8821 ctggcaattt atttatccca tttccaatta acttcaagtg taaatttgat ggttcttttt
     8881 tcagatttaa tttaaatatt ccatcaaaag tatctttatt atcgcttcca aataaactta
     8941 tattgccatt tatatttgta gctgttacat ttacaattcc attgtttgct ctaaatttta
     9001 tttcagatga tatagtttca gctgttacac ctgaaatccc actattagta tttatattga
     9061 aaggatttgt tacattgtta tcaacaatgt tagcaattcc gtcattgaca tcaacagtag
     9121 ctcctccttt aatattataa agttctactg aaccactttc aacatctact ttaaaattag
     9181 aatacatttt atcgggaact ccaattttta tcacatttac catcctatct ttatttgcat
     9241 ttatcatatt gtcgccattc atatcttgca aatcactatc tttcttatct atttttttct
     9301 tagcacttac aactagcttt ccatttttta tattattaga agaattttct ttatatacag
     9361 aaaaagtaca atttttttca ttagttacac ttacgtaatc aaactcaaat ttattggtat
     9421 tcgtcttttc aacaaccaca cctaaattat ctgattctat aagtatttca gaaacttcat
     9481 ttccttcaac tgaagttaag tgttttaaaa tatttggagt catatccata ttattatatt
     9541 taatcatatc taaacactgt ttatatatat tggcatcaat acctccaact tttgttatac
     9601 ttttagctcc ttttaaaata cctttattac ttccatcagc aactaaaacg attggttttt
     9661 ctttggctaa aggagataat gttagtgcat ctactaattg atatccattt gttatataaa
     9721 aatctgtagc tccattataa aacttttcca ttaccttttt attggtctca aatctatcat
     9781 ttcctccgat tctaattgct ttagtttcat ttactaaatc ctcatttatc gcagatttgc
     9841 cacctatagc gtaaacattt aaaccttcag tcttaaatgg aactgatttc ccatctgtaa
     9901 gtattatagc tcctttattt tttgcaacta caggtgctat actcatagca tcagcctctc
     9961 ctacaaatcc atttgtaagc attacctctt ttacactact tacttcattt atttttttag
    10021 ctacattata actagtttca attctattgt taccatttat tctttccact tgaatacctt
    10081 ttctttttat atctttttct actgaatttt caatagtatt ataaccacca attatatata
    10141 ctttttttac aacatttaaa ctcttattat ctagtctatt taaagtagct tttggtattt
    10201 cacttttttt agtcaaaagt attggtgcgt taatagctcc agctaatcca cttgatgaaa
    10261 gcccatcaga taaattttta tctccattaa ctaatattac agtatcataa gtttgtctat
    10321 ccgctataag tcctgctgtt tcatatctat caattcctat tattgaatct tctttaatct
    10381 gtgcatttgc agttaaatta ttaaaaagaa acatagtcaa aactaaaatt aatatactta
    10441 gttttttact gaattttttg aattttttat tcataatata cactattcct cctgtaaatt
    10501 aaggtcttta atttgcttat aaattatccc cttatttaca aataataaca taatattata
    10561 gtaacgtata tattacctta aaattatcag taactttata tcaatcatct tagcttattt
    10621 atataaattt ttttatatta cttttcaaat aacagtcata ctaaaacaat ttcatcatat
    10681 aatttgaaaa ttattactat ttacgcagct tttatcatca tcttaccacc atcaaatata
    10741 tattcaacca tattattctc atataaataa gttatataag aacgtattgt acttccaacc
    10801 aacacatatt gattagcatc aagcttgaca ttgtacaaat cacacatttt ttcaataact
    10861 tcatcaatca taactggctc ataacaaacc tttttaatat tatctattat ttcttccatc
    10921 ttcttcttat taatattaat taaacttttt atatctgtag ttttgacaga gtgacttgga
    10981 acaaagaaat cagcctctaa cattctcaat ttttctagtg tcttaaactg tgaatctata
    11041 tccagtagga agaaaaaatg atatttagta attatattct ctggtgtaag actatctgca
    11101 acaaacaaaa cattatctgg agttctaaca ccaatcattt caaaataatg acctggaaga
    11161 gaaatcgctt caagttctgt atctacaatt ttgccatttg aaggtataat ataatcaact
    11221 tcactttcct ttgctaataa aaatttattc ttcagtgctt tacttggata gccaccatat
    11281 aaaaatgctg attctaatat tggattttct gtaaaatatc cttcaatttt agtcgtagca
    11341 atcttgcatt ttgtttgatt cttcaaatat gcatttcctc ctatatggtc tgcatttgaa
    11401 tgagtgttta ttattaattt aggatttaaa ttatgttctt ctaataatct taaaacttgt
    11461 ctagctgtat ccttattatt tccactgtca attaaaattg catccttacc atctacgtat
    11521 acacctacta ttgtagggag tggaatataa tatgtatttc cttttatatg ttctagagtt
    11581 aatttagcca ttttataacc tccctttaaa tttactttta attatagcat taattttctg
    11641 aaaattccaa tcaaattgtt tttataatat atttttattt cttttattaa aaattggaaa
    11701 aactatataa tatatattat aatctatata taaggagtga tgttattgaa aaaagataga
    11761 ataacttttt cagaaatttt aatattaatt gtaggctgta tattaatggc catttctctt
    11821 aacttatttt ttaatccaca tgcaatcgct gctggtggta taacaggact tggagttgtt
    11881 ttaaattcat tattcggtgt agaactttgg attgtcaatt tacttttaaa tgttccatta
    11941 ttcatatttg cttacaaaat actttcaaaa aaagattgtt ttaaaacggt tttaggaata
    12001 atttttctta ccatagcact taagcttact gcaaatatgg ctacattaga tataacaaat
    12061 gatatgtatc ttgcaattat atctggttct attttaatgg gagttggtca aggacttatt
    12121 tttagaataa atggctctac aggtggaact gatttaatgg cactcctact aaataaatat
    12181 tttcctacat ttagtatacc tgttttaatg ggtattgtag actgcgttgt agttgtttta
    12241 tcaggtatag taaatagaca ggttgaaatt gcactttatt caactgtggc tttatacatt
    12301 ttagtaaaag ttagtgactt gcttattgaa ggatttaatt attccaaatc attcactatt
    12361 atatctgacc tttcaaaaga tataagtaaa aaaataatgg aagatttaga tagaggtgca
    12421 actattctaa aaggagaagg tgcatatact ggagaaaata aaaatgtact tttagtagta
    12481 gttgaaaaga aagaagttgt cgaattgaaa aaattagtaa aaaatgtcga ccctaatgct
    12541 tttattataa ttacagatat acatgaagct ttaggtaatg gatttaaaaa aatagaataa
    12601 ctaacaaata aatagcaagt ataattaaca tatacaaatt caacttttta tatgttatat
    12661 tatacttgct atttatatat tatacttgct atttatatat tataattgtt gtttttaaga
    12721 taaaaattaa atgtatcaat tattgtttta tacaagtatt tccaaatccg ttctcattta
    12781 gatagtatgc ttagaaattt tagaattatt gagtctaact ttattactta ctttacttta
    12841 taacaatcaa atacaaattt aaatattata aaactacaaa ataatttaaa gcatataatg
    12901 tcaatatgtt taaattataa aatattcatg tagttatata ataaataatt tataaatata
    12961 gccaacttag cctaaatacg tatataatat agctaatatg gttcttatac ttgataccat
    13021 caataaaact aaaaatataa aaaggagaac ttaaaatgag tgttagttta caaaaaggac
    13081 aaagagttag cttagtaaaa gataataatc ctgtaaaaaa tctagtagta ggcttaggat
    13141 gggatatgaa taaattgggt aaaaaaaatt atgacctaga tgcatttgca atagcattga
    13201 ctaaccaaga taaaatgaat gttagaggtg acttggttta ttttggaaat cttaaacacc
    13261 cttctaaagc tattatacac actggagata acttaactgg aaaaggtgaa ggtgatgatg
    13321 aacaaataat tgttaattta gaagacatac ctgaatatgt acataaaata gtttttggag
    13381 tttctatata caaagctaaa aaaagagacc aggattttgg tcaaatgaac aactctttta
    13441 taagattaat tgattcaaat tccaagcaag aattatttaa atataatctt caagaagact
    13501 tttctggtaa agtaacagtt ttggcaggag aaatttatcg tagaaatgaa gaatggaaat
    13561 ttaatgcttt aggaattggt caaaatgaag agcttcgtga attaattaat acatataagt
    13621 aataattaca ataaaaaatt tataatgagg agttggttta aatgggtata actttagcaa
    13681 aaggacaaaa agtaagttta acaaaaagta accctggtct aaaaaaagta atagtaggac
    13741 taggatggga tattaataaa tatgatggtg gctttgattt cgatttagat gcctctgcat
    13801 ttttaactgg aactgatgga aaagtaacga atgatggaga ctttatattc tataataatt
    13861 taaaacacgc ttctggagct gttgaatata tgggtgataa tagaacaggt gttggtgatg
    13921 gtgatgatga acaaataaat gtagacttat ctaaaatacc tcaaaatatt gctaaaatat
    13981 catttagtgt tactataaac gaagcaatta caagaagaca aaatttcgga caagttgaaa
    14041 attcatatat aagaatatat aatgaagaaa ctaatgagga acttattaaa tatgaattgg
    14101 gtgaagattt tagcatagaa acagcaatag ttgtggcaga actatataga cataatggag
    14161 aatggaaatt taatgcttta ggttctggat ttgaggatgg acttgcagga ttgtgtaaaa
    14221 attttggcgt taatataggc taatatatct aaataaaaat aagagtatat tgatatactc
    14281 ttatttttat ttagatatat tataaactgt ttacacttct actcttcttt ctcgcttgtt
    14341 ttttcccata ttctactgaa atatcaaaaa atgctgaaat attttctgta aaaaacttgc
    14401 ttctatgata tgcaatatca aatgtcctat gtaaattaat accttcaata tcacaagccc
    14461 acaaaagatg cttttttaaa taatcctcaa taagtaattc ggatataact gcaatgccaa
    14521 aattatctac aactgctctt aatatagctt cagagttata acatgaccat ctaatattca
    14581 ttgggatttt taattctttt aattgctttt ctaattgtgc tcttgtacca cttcctaatt
    14641 cacgcataat taatggttga tttgaaagtt ctgaaacttt tatagagtct cttttataaa
    14701 actcatgctt gtgtgaacat ataagtacaa gattatcatt aataatgctt tttgtaacaa
    14761 tatctgggtg cttaattttt ccttctacaa tcgcaatatc taattcacta ttaagtaatt
    14821 tttttgcaat cagtcttgta tcttctacaa atacttcagg ttctataaga ggatttacct
    14881 tgtataattc taacattatt ggacttatta cacatgtacc aacagttact gttgccccaa
    14941 ctcttatacg gatatttttt gcacaatgct tcatacaatc attcatttct tcatttacag
    15001 ctaaaagatg cctcccatat ccaagaagtt ttttccctgc ctcagttaaa tataattttt
    15061 ttgaaattct atcaaatagc ttaacaccat actctttttc tatttctgaa atagcttggc
    15121 taactgatga ctgggtaata tacatatttc ttgctacttc actcatttta ccacattcag
    15181 caaccttaac aaagatttca agactacgaa ttgtcatatt atcacaacct tagcaaacat
    15241 tagtaaatgc ttatgatttt attaatattt tagtatttta caaatatatt gtcaagaagt
    15301 ataattttat tatagagtta taaagtagat tggagtgtga tatattgtga aagtattaat
    15361 tataggtgga gttgctgctg gaacaaaaac tgctgcaaaa ataaaacgtg aaatgggtga
    15421 taattgctct gttacaatac taaataaagg tgatgatatt tcttatgcag gttgtggtct
    15481 tccatattac gttggtaaga taattgaaga taaatcatct ttaatcgtaa atacacctga
    15541 aagtttttct aaactaacag gagcagaagt tcgttgtgga gttgaagtta catctattga
    15601 tagaaatgca aaacaagtaa ctttgaaaac gctttcaaca ggagaaaaag aaaatctaag
    15661 ctatgacaaa cttgtaattg ctacaggggc agacccaata aaaccaccaa tacctggaat
    15721 agatttacct ggagtattct ttgtgcgtac tccaaatgat gctataaaac taagagattc
    15781 tattgaaaac ggtattaaga gagctgttgt tattggtgga ggtttcattg gtcttgaaat
    15841 tgctgaaaat ctttctgcaa tgggtatacg tgtaagtgtt gttgatatgg ctgaacatgt
    15901 tatgcctgga tttgatactg attttgctga atacgttgaa aatcatatgg ctgataaagg
    15961 cataatgatt tttacaggtg accaggttgt aggtatcgaa ggtgaaaata aagttgaaaa
    16021 acttcgtact aaaaatagag ctattaaaac agatttagtg gttatgtcag ttggaatccg
    16081 tcctaacaca ggttttctaa aagacacagg tttagaattt gcccctaata atacaattat
    16141 tgcagatgaa tatatgctta caaatgacaa agatatatac gtagttggag actgtgcttt
    16201 tgtaaaaaat tctttaacaa ataaacctac atggtcacct atggggtcat ctgcaaatca
    16261 tgagggtaga atttgcgcac aaaatatatc tggaaaatct aaaacttaca atggtgttct
    16321 tggaacaaca gtagtaaaat tacctgagct caatgcagga aaaacaggtc taagtaaaga
    16381 aatagctgaa aaagaaggtt ataatgtttg ctctgtaacc atagctactg atgataaagc
    16441 tcattattat ccaggtgcat ctaattttat tataagaatg gttgctgaaa aaaatactag
    16501 aaaattatta ggtgttcaag ttatgggacc tggagcggtt gataaaatag tagatatcgc
    16561 tgctactgca ataactttag gcgctgacct ttattcatta gaaagtatgg accttgcata
    16621 tgcaccacct ttttcaacag ctattcaccc ttttgtagtg gcagtaaatg ttttacaaaa
    16681 taaacttaat ggagaacttg atagtgtttt acttgacgaa attgaggatt ttgacagttg
    16741 gactaaactt gatgtttcaa aagctccttc tattcctagt ttacgttata ttcctgttgg
    16801 tgaaattaat ggagaaattg aaggccttgc taaggatgaa aaaattcttc ttatatgtgc
    16861 taaaggtaaa aatagctata tggcgcaaaa tcgcttaaga cgctttggct atacaaatac
    16921 gaaagttctt gaaggtggaa tactatttta tccaaatctt aaggtaatgg aggagtaaat
    16981 atgagtaatg ttacagcaga acaaaaaaag gaagtaaaag gtagaggttt tctaccaagc
    17041 agggatggag aacattttgc agcacgtata ataactgtaa atggtgtaat aaatgcatca
    17101 caagcaaaaa aaattgcaga agctgctgaa aaattcggaa acggtcagtt agcatttact
    17161 actagactaa cagtagaatt acctggtgta aaatttgaag atattgaagc tctaagtgaa
    17221 tttattgcta gcgaaaatct aataacaggt ggaactggat caagggttcg tcctgttgtg
    17281 gcttgtaaag gtactgtttg tgttcatggt ctagctgata cacaggcact tgctgctgaa
    17341 atacacgaag aattttacaa aaattggtat gatgtaaaac tacctcataa gttcaaaatt
    17401 ggtgttggtg gatgccctaa taactgtatt aaacctgacc taaacgatct tggaattgtt
    17461 ggtcaacgtg tacctgacta tgattcagag ctttgtgttg gttgtaaaaa atgtgctgtt
    17521 gtagaggtct gtcctgttaa agcagctaaa ttaacagata aaggtaaact tgaaatagat
    17581 agtaatctat gtaataactg tggtaagtgt atagaaagtt gtaattttga tagtattgaa
    17641 gaaaaagaat ctggttataa agtctatata ggagggaaat ggggaaaatc agttcgtcct
    17701 ggaacacaga ttgatagatt attttcaaaa gaggaactta tgactttaat tgaaaaagca
    17761 attcttttat ttagagaaca gggtaacaca ggtgaacgtt ttggaataac tatcgataga
    17821 atcggtgctg ataaatttat agaaatgctt ttatcagatg aagttttgga aagaaaagaa
    17881 gagatactag aggctctttt acaccttaca ggtggagctg tatgctaaca ataaatattt
    17941 taattgtaca gataacctat ggaaaaaatt ttagttaaga ataattaaaa ttctatatat
    18001 gatatatgat aaatgaggct atctcaaaac acagatacgc ctttttttca ttgttgaaat
    18061 gataaagtat atttgagttc atataaaaaa gagtgtctcg tgaattataa aattcatttt
    18121 gaggcaccca cattatttta taataattgc ttattaattt tattttaact atataaaaag
    18181 tacaaaaagt aagaatatcc aatattctaa aattaatttt gaattgtatt gattgaaaag
    18241 tttactattc cactatttcc atcttgattt actactagat accatgttcc agtattagga
    18301 actctcattc tacatggatt tttctttgca aatccaccat agtaatcata atttctttga
    18361 tttttaaatt tcacataatt tatatggtct aacaatatta cattggcttg tttctctaaa
    18421 tttacctcta caatatcccc tttttttaag ttcatcttac tataactata ttccattgaa
    18481 ttactcctcc agtatcgaat aatctttgtt atttactcat ctcaaatatg taaaaattca
    18541 tttaaaatat tacaaatact atataattag actattatcc agttttaacc ttatttatta
    18601 caatccaaag gttattaaaa atattattgg caacaacttc tccatcccat acaactcttt
    18661 cttctttatt ttctaataaa gcatagtacc cagagtcaga actttcatct ttatagactg
    18721 taacataaaa ctcttcatca ctatattcag gtatattttt aaagtcttca gatattttac
    18781 atgttaatat ataaccttct aattcttcat ctataaacaa agcaattcct ccaatctcta
    18841 tatttttact aattatacca tattatgtca taaacttttt attttattac aaatttctat
    18901 tttttcttta ctttataaat aaattatata aattttcact ttttaacttt atattatact
    18961 aattaattct tttattttcc tatatatttc tttataattt ataaatttag ccattaa
//
LOCUS       DAEPID010000076        18307 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.076, whole genome shotgun sequence.
ACCESSION   DAEPID010000076 DAEPID010000000
VERSION     DAEPID010000076.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 18307)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 18307)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..18307
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.076"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            complement(448..1320)
                     /locus_tag="KR257_002984"
     CDS             complement(448..1320)
                     /locus_tag="KR257_002984"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424273.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MurR/RpiR family transcriptional regulator"
                     /protein_id="HBH0031655.1"
                     /translation="MEETNEMKDSKHLISNIQSQYTRLSKGQKLIAQYILNNYDKVAF
                     MTACKLGETVGVSESTVVRFANALGYSGYPKLQAALQELIKNKLTTVQRVEMAHDYSD
                     DFAILNKVLKSDIDNIRSTLEEIDERAFKEASNKLLRARKIYILGMRSSFVVAQYLGF
                     YLDIILDNVHIIRMDMGDAFEQIVRINEEDVIVAISFPRYSKKSYQIVNYAKEKGAHV
                     ISLTDSLFAPVASLADNTLLVKSNMASFVDSLVPALSISNALAISVGMKEKEDIKQHF
                     DDLEQIWKRYSVYE"
     gene            complement(1714..2292)
                     /locus_tag="KR257_002985"
     CDS             complement(1714..2292)
                     /locus_tag="KR257_002985"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428972.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="methyltransferase domain-containing protein"
                     /protein_id="HBH0031656.1"
                     /translation="MAYAKYLTKITDINKFYLENIINEGDIVIDATMGNGYDTRYLAE
                     KVGEKGFVYAFDIQEEAIKSTRKKLEKEGYTDRVKLIFDGHEKMNQYIKEEVSCVLFN
                     LGYLPRAKHSIITKPDTTLKAIKLSLEMLKENGVISIAIYTGHDGGQEEKDCIYNLVN
                     NLNQDEFNVLESKFLNQVNNPPQLILIEKKKA"
     gene            complement(2350..3066)
                     /locus_tag="KR257_002986"
     CDS             complement(2350..3066)
                     /locus_tag="KR257_002986"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890007.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="rRNA pseudouridine synthase"
                     /protein_id="HBH0031657.1"
                     /translation="MRINKYIASCGIASRRKAEEIILGGRIKVNGSVVKELSFNIDEE
                     KDIVEFDNKKVKPSENYIYIVLNKPEGYITTVKDQFNRPSVIDILKDVRERVYPIGRL
                     DYETSGLLILTNDGDLTYKLTHPKHEIDKMYVASVKGIISDDEIRQFETGLKIEDYTT
                     APAKIRVTKENKEKNYSVCEITIHEGRNRQVRKMCKAINHPVLNLRRISVGKIVLKDT
                     KVGEYRYLTEDEIKYLKSIK"
     gene            3257..4342
                     /locus_tag="KR257_002987"
     CDS             3257..4342
                     /locus_tag="KR257_002987"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435146.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AI-2E family transporter"
                     /protein_id="HBH0031658.1"
                     /translation="MIIISKENIKYYLIVVFIGILFFKFINTPSDFISSIEGFLKFFS
                     PFLLAILLALLLNPLVMLFEIKFKAHRLLAIFLSYIFIGFILAFAIRLLIPSIANTLN
                     RLINEMPMYTDYIDSFIEKNMSNIYFLKTLIPHIQHSLDNLLKEASNFVGKIPKNFLI
                     YTLSISSMLFNMTMGFILSIYIIYDKEKIALGFKRFLYSSTARNKADNIIEFFRTTHD
                     IFYDYLLGRILDSLIIGIIAFLGFQFVIRIENALFLASIIFLGNIIPYFGPFIGAIPP
                     IAMTILYSPQKTIWVIAFLFILQQLDGNFIEPKVMGNQVGIGAIWVISAILVGQSLFG
                     FIGVFLSVPIAAVVKTYVDKYIDNRLQ"
     gene            complement(4497..5156)
                     /locus_tag="KR257_002988"
     CDS             complement(4497..5156)
                     /locus_tag="KR257_002988"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897209.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0031659.1"
                     /translation="MRGRVILLISILSIFLVGCSFNKKDEINLVEQGKTYLEKHNYKK
                     AMESLSSALEEDSTNENARAMYMQAMRMSNMTEFEELKNYEGAIKELKLIEKIKNGSS
                     VIKEEATKKKEELTKLEKEQNEAEEQRKKKAKDTAGEDRYRVESDARKSSYSGSSKNN
                     KSSSKNNDKKSDSNKSDNSNSSSQNQEKPNNSNPTPAPTPQDTTGGSDSGGNSQNSNN
                     Q"
     gene            complement(5373..6665)
                     /gene="lysA"
                     /locus_tag="KR257_002989"
     CDS             complement(5373..6665)
                     /gene="lysA"
                     /locus_tag="KR257_002989"
                     /EC_number="4.1.1.20"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435141.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="diaminopimelate decarboxylase"
                     /protein_id="HBH0031660.1"
                     /translation="MKLHGTMTVNNDELYIGGVSCLELSKKYQTPLYVFDEALVRQNC
                     REYVEYFKAREGKNKVAYAGKAFLPLYMCNLINEEQMCLDVVSGGELYTAYKSNFPME
                     KVFFHGNNKTKEEINMGLDLGVGKFVVDNFYELDLLEALCEDKGKTQEIYFRITPGIE
                     AHTHDYIKTGQIDSKFGFALVNGDLFRAIEKLSEYKNIKLVGLHAHIGSQIFDVEPYI
                     DTVDIMMNLVKEIKEKFNIQLTEIDLGGGVGVYYSEGDKPKTIKEFCETIITKAETSC
                     KELGIEVPTLVIEPGRSIVANAGSTLYTVGSIKDIKDVRVYVSVDGGMTDNVRPSLYQ
                     ASYECSIVNKINHEAMNHVTIAGKCCESGDILIGDINIMDIKSGDILITTSTGAYGYS
                     MSSNYNKIPRAAVVSVFDGNDKIICKRQSYEDLLALEI"
     gene            complement(6683..7876)
                     /locus_tag="KR257_002990"
     CDS             complement(6683..7876)
                     /locus_tag="KR257_002990"
                     /EC_number="2.7.2.4"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424287.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aspartate kinase"
                     /protein_id="HBH0031661.1"
                     /translation="MSIIVQKYGGSSVADTEKIKSIAENIIERRKENPQMVIVVSAMG
                     KSTDEYITLAKELSNEPSKRELDALMSTGEMISASLLSIALNALGCKAISYNAYQLNI
                     KTSGLHGKSQIDDINVNRIKNSLDEGNVVIVTGFQGINEDGDVTTLGRGGSDTSAVAL
                     AVKLNGKCEIYTDVDGIYFTDPRKYSKASKLDEIEYEEMLELASLGAQVMHSRSIELA
                     QKYGVEIYVGRTCGTEKGTYIRGGKDMKLEDKVITGLATSDDDSSITIKDFKAENISS
                     LFEDIATIGISVDMISQTAPILDKISVSFTVPKEELGECKKIVSKYTDEEHVVIDNNI
                     TKFSLVGLGMKNTSGVAAKVFKIFNENGIMIKLITTSEIRITCAINSDDKQVAIEKIA
                     EVFNI"
     gene            complement(8237..8854)
                     /locus_tag="KR257_002991"
     CDS             complement(8237..8854)
                     /locus_tag="KR257_002991"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428983.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0031662.1"
                     /translation="MTNMEKEILLLISRVRCVTESQFRKIYGDQKRYNKKNFKKTLRK
                     MCSEYTLKKYPCDVDYYNYKDLSYVYYLNGSKLFKGDDLIKALVGSELVVRINTAGCD
                     VKRFYRNVSVDDVKYDLFIEYTDQFGNIKQVLVDVDLNNEIDISKYENLSKKIDKSTI
                     PFFKVPNVLVVTPDNLSELNDLERYDNEYSINFIDLGLNKLFNCI"
     gene            complement(9024..10724)
                     /locus_tag="KR257_002992"
     CDS             complement(9024..10724)
                     /locus_tag="KR257_002992"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424292.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0031663.1"
                     /translation="MKRYLKTYGVALIIVIIYAFIKLPVLRLDFTSLFSVGIIFFVVA
                     GILDMMLDRNERASKMAKYNFSIAIALLVYIVVVPFITSTPVLHAKSYRELLGKVTES
                     KFTDDISPVSVNDIRLVDEDMAMKLGDKKLGEVPAIGSVSKLGKFHIQNVDGELYWVA
                     PLVHRDIIKWITSLSGTSGYVKVSASNPQDVQLVQEIDGKPIKIVYQPEAYLHQDLQR
                     HLYIHGIVNVGMTDFTLEINDEGRPYWVVSLYEHKIGYGGANATGIATVDAETGKINV
                     YDVKNTPKWVDRIQPQSFVTDQIKDWGVYVNGFLNSVISEKGVLVPTEGTSLVYGNDN
                     RSYWYTGITSSGGDESTIGFMLVDSRTKEARLYKQPGATETAAMKSAEGNVQEKNYEA
                     TFPVMYNILGQPTYVSSLKDKAGLVKRVAFVSVEDYNVLGIGEDKNEALRNYKDALES
                     KGNDLKLDNDLKDEVLEGTVTRISPDVRGGNTNYYVTLDSNKDIIFRATSKVSSELPL
                     TQVGDKVKISYSKEESGVIEMSEFDNLNIANFEDKKAKEKTGTDENTDSKDSENQGNV
                     "
     gene            complement(11121..11684)
                     /locus_tag="KR257_002993"
     CDS             complement(11121..11684)
                     /locus_tag="KR257_002993"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003433003.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0031664.1"
                     /translation="MNKVYIVTTYTGTILSYLIRNISKKLYTHVSISLNENLKPMYSF
                     GRLNPRNPFIGGFVEENINQGLYAIRKNTVCRVYSLEVDNLQYENLYKNIKLISDYRE
                     DYYYDTMALIYLLMNIQRQSEYKYVCSNFVADMLEKSEIDILNKQAFEVTPNDFYNLS
                     GLTLEYEGLLSEYNSRQHSYVSKIANI"
     gene            complement(11843..12556)
                     /locus_tag="KR257_002994"
     CDS             complement(11843..12556)
                     /locus_tag="KR257_002994"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428988.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF2140 domain-containing protein"
                     /protein_id="HBH0031665.1"
                     /translation="MGKVAKILLSLIVIVLVLVGIVVYILTPKERYDVSSQNNKIIDE
                     EYLSKGSYINSMEVVKNPLRMVGKISVSEEEFKNLIYTLMQKHGINELENNFVEMKNG
                     KIKVAGPYKVFGLVNSQYELELRPTLKDGNLVVSLENVKIGKFKLSDKMLEKILSNYN
                     KKVPFEVNGNKITLEKSYLYPITLKNISIKKGNVDLDMEVEIDLKSQINGALGYLKDS
                     GKVQDILNHLINLKKTSVG"
     gene            12848..14512
                     /locus_tag="KR257_002995"
     CDS             12848..14512
                     /locus_tag="KR257_002995"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902971.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glutamine--tRNA ligase/YqeY domain fusion
                     protein"
                     /protein_id="HBH0031666.1"
                     /translation="MSNETNSSNFIKNIIINDLETGKHDSIITRFPPEPNGYLHIGHA
                     KSICLNFGLAKEFNGKANLRFDDTNPLKEDVEYVESIKEDVKWLGFDWNELNFASNYF
                     DEMYKRALILIKKGKAYVCDLTQEEMREYRGTLTEPGKESPHRNRTIEENLDLFERMK
                     NGEFKDGEKTLRAKIDMSSPNINLRDPIIYRISHSTHHNTGDKWCIYPMYAFAHPIED
                     AIEGITHSICTLEFEDQRPLYDWFVKECEMENIPRQIEFARLNINNTVMSKRKLKQLV
                     DEGIVDGWDDPRVPTISGIRRKGYTAEALRNFCSEIGVSKVNSTVDSQMLDYFLRENL
                     QPKAPLTMGVLRPLKLIITNYPEDKIEMLEIENNAKDESQGKRLVPFSRELYIEQDDF
                     MEEPVKKYFRFFPGNEVRLKGAYFVKCTDVIKDENGNVVEIHGTYDPETKSGSGFTGR
                     KVKSTIHWVDAKSAIPCEFRLFEPLILDDIPENEGKHFLEQINPNSLEILQGFVEPTQ
                     IKDAKPFDKFQFVRNGFFSIDNKYTTDEKFVFNRIVPLKSSFKPGK"
     gene            complement(14619..15518)
                     /locus_tag="KR257_002996"
     CDS             complement(14619..15518)
                     /locus_tag="KR257_002996"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435130.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YegS/Rv2252/BmrU family lipid kinase"
                     /protein_id="HBH0031667.1"
                     /translation="MKKVKLIYNPNSGEKKILSNLDTIIELYQEKNYLLIPYRLTIKE
                     PVKNAFKEVDSSYEHILIAGGDGTVDLVVNAMKELDIKIPIGILPTGTANDFSNALQI
                     SFDIKEAINEIINSKPKKIDIGKVNNKYFINVASAGMFTDVSQRINTDLKNSFGRISY
                     YIKGIEEALYMRKFKIKVSSEEMYYDGDMYLMLIFNGKTAGNINLAYKAEIDDGYLDV
                     IIFKGMPIPKSIPVLISVLRGDYLDQYNGNEILYFKTKKVHIECEDSLITDIDGEKGP
                     DFPLNIECIKDGIEVMGICSEKS"
     gene            complement(15545..16183)
                     /locus_tag="KR257_002997"
     CDS             complement(15545..16183)
                     /locus_tag="KR257_002997"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003356606.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="lactate utilization protein"
                     /protein_id="HBH0031668.1"
                     /translation="MDQNLNWLNEKRIEKTIKSLENNNMKGYLVSNKEELLKKIEEIV
                     KAGSLVGCGGSMTLFETGVIDFIREKYNFLDRYAKDIKPEEMKEIYRKSFSADAYFTS
                     TNAITEDGELYNLDGNGNRVAAMIYGPDKVIVIAGVNKIVKDVDEAIKRTKTIAAPAN
                     CKRLSTNTGCKTTGICIDCSSPGRICCSYTLIKRQLTPERIHVIFLNEDFGY"
     gene            complement(16520..17518)
                     /locus_tag="KR257_002998"
     CDS             complement(16520..17518)
                     /locus_tag="KR257_002998"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424321.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4003 domain-containing protein"
                     /protein_id="HBH0031669.1"
                     /translation="MEQSFINGKVNLLIENYKALNEVKGSWQMGLIQHSCALAFTLKN
                     KKISPRLVEERIELIKKNTGLFSNFRGYNMFYMATLLSFESNPESSFKMILDIYKELK
                     SEKFWGDTYLPLTASIVYENREKMDYLTCISKMKIIYDYMRKKHPFLTSSDDYCNIAL
                     IAIHSKNLDEDLEYIEKCYEFLNENGFYKGNDLQALSQILLFSDDRTMLKCKKTIELK
                     KAFKENDCKMNYYGYPIIGAISLLDYREDEIIEEIKNVSNKLKEEKGFGNWSLGKSNR
                     VMISSAIVASIYADLIRNENNIGSITNNIFLNIVVAIQIACVMAATSAAIASSSSN"
     gene            complement(17616..18191)
                     /locus_tag="KR257_002999"
     CDS             complement(17616..18191)
                     /locus_tag="KR257_002999"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424324.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0031670.1"
                     /translation="MKLKEALITCVVCSVCLTPLLVNGETKIDADHCKESIVNIDTIV
                     KSGKSFNSKYNQGMEDYKNSDEYKLKVQKEKLQNQLGIKIKKLVPITFEVSYYTSLNQ
                     ENGYGAITATGDDLEDGFVANNHLSFGTKIIVDGKLKTVMDRGSSKYFSNSNAIDVFV
                     PKWSNESESEYYDRVNNMGRHYKKGYIIVEE"
BASE COUNT         5925 a         3044 c         1938 g         7400 t
ORIGIN      
        1 tccccaaaaa tggctactta aaaaatcaag atttcatacc taactactaa ttctatgatt
       61 tttaaatttt tcaacttctt tgtcaaagtt aaaataaaat actaaaagac acatattata
      121 gtgaacaaaa aagatagaaa tacatatttt aatagaattt taataagata ttatatactt
      181 aaatacaaat aaaattaatt ttataattgt taattaagga aatgatattg tttagagaaa
      241 taaaaaaagc actctccatg aagggaaatg ctttctttaa taaattagtt gatgtagtaa
      301 agatatattc agaatacatc tttatgtttt gagtctcgaa atatttattt gtattattta
      361 aacgaaaatt tattttttaa gtgataatct agtatttatt aataaggcta tgattctcaa
      421 tttcatagcc ttattaatac acaaacttta ctcatacaca gaatatcttt tccaaatttg
      481 ctctaaatca tcaaaatgct gtttaatatc ttctttttcc ttcatcccaa cagatatagc
      541 aagagcattt gaaatactaa gagctggaac tagagaatct acaaatgaag ccatattact
      601 cttaactaga agagtgttat ctgcaagtga tgctactggc gcaaataagc tatctgttaa
      661 tgatattaca tgggctcctt tttctttagc ataattgaca atttgataag atttcttaga
      721 ataacgaggg aaactaatag caactattac atcttcttca tttattctta caatctgctc
      781 aaaagcatct cccatatcca ttctaattat atgaacattg tcaagtatta tatctaagta
      841 aaaacctaaa tattgagcta ctacaaaaga actcctcatt ccaagtatat atatttttct
      901 cgctcttaaa agtttgttag aagcttcttt aaacgctctc tcgtcaattt cttctagtgt
      961 agaccttata ttatctatat cactttttaa aactttgttt agtattgcaa aatcatcgga
     1021 ataatcatgt gccatttcaa ctctttgtac tgtagttagt ttatttttta tgagttcttg
     1081 aagtgcagct tgtaatttag gatatccact ataacctaat gcatttgcaa atcttacaac
     1141 tgtagactca cttactccta cagtttcacc caatttacat gcagtcataa atgcaacttt
     1201 atcataatta tttaaaatgt attgtgctat aagtttttga cccttactca atctcgtata
     1261 ttgagattgt atatttgata tcaaatgttt actgtccttc atttcatttg tttcttccat
     1321 ttttttctcc ttttagttat ataaactatt ttgttttatt aacactgtct ttttctctaa
     1381 aaattttatt ttttatctca atttcatctt agtttttatc atagcttctt aaactcataa
     1441 aattctaact tttctgtacc ttatacttca catagtattt tcgattaaat ttattatacc
     1501 atctttcctt gcatttttta atatttatcc aatatttctt ttaaattttt caatttttac
     1561 tcatttaaaa gttatctatc ttattttgca tatttagatg tatattttgt tttgagaata
     1621 aactgttgta tacttattat ttaaagtatt tttaataggt cacactatat atattaactc
     1681 ttaatacaat cttgtcaagt tttttagtat ttattatgct tttttctttt caattaaaat
     1741 caattgtggt gggttattga cttgatttaa aaacttagat tctaaaacat taaattcatc
     1801 ttgatttaaa ttattgacaa ggttatatat gcaatctttt tcttcttgac ctccatcatg
     1861 ccctgtatat atggcaatgc ttattactcc attttctttt aacatttcta aacttaactt
     1921 tatagccttt aaagttgtat ctggtttggt tataattgaa tgtttcgctc ttggaagata
     1981 acccaaatta aataaaacac atgaaacttc ttcttttata tattgattca ttttttcatg
     2041 cccatcaaat atcaatttta ctctatctgt atatccttct ttctctagtt tctttcttgt
     2101 agactttatt gcttcttctt gtatatcaaa agcatataca aagccctttt ctccaacctt
     2161 ctcagctaga taccttgtat catacccatt tcccatagta gcatcaatta ctatgtcacc
     2221 ttcatttata atattttcta aataaaattt atttatatct gtaattttag ttaaatactt
     2281 tgcatatgcc ataatactat ttctccctac tattaacttt atttcatttt ttctcaattt
     2341 atttttatct tattttattg attttaaata ttttatttca tcttctgtta ggtatctata
     2401 ttctccaact ttggtgtctt ttaatactat tttccccaca gaaatccttc ttaaatttaa
     2461 aactggatga tttatagctt tgcacatttt tcttacttgt ctatttctac cctcatgtat
     2521 agttatttca cacactgaat aatttttttc tttattttct ttagttaccc ttattttggc
     2581 aggtgccgtt gtgtaatctt ctatttttag tcctgtttcg aattgtctta tctcatcatc
     2641 acttataatt cccttcacac ttgccacata cattttatca atttcatgct ttggatgggt
     2701 aagcttatat gttaaatcgc catcattagt aagtattaat aaaccactag tttcataatc
     2761 taatctccct attggatata ctctttccct tacatcttta agtatgtcta ttacactggg
     2821 tctattgaat tggtctttta ctgtagttat atatccctct ggtttattta atactatata
     2881 tatataattt tcacttggtt ttactttttt attatcaaat tctactatgt ctttttcttc
     2941 atcaatatta aaagataact cttttactac acttccattt acctttattc ttcctccaag
     3001 aattatttct tctgcttttc ttcttgatgc tattccacaa gaagctatat acttattaat
     3061 tctcatactt aatccttcct tatcttaaat tatgtgtgtt taatattttt atcaatgtta
     3121 attttgctac attattatac tatactagac cttaattaaa aacaagcaaa aaaattattt
     3181 aattttccta aataattgta atttcttttc acatactatt aatatgtaat agctgactaa
     3241 acactatttt aaggaagtga ttattatttc aaaggaaaat ataaaatatt atttaatagt
     3301 cgtgtttatt ggaattttat tttttaaatt tattaatact ccatcagact ttatatctag
     3361 tattgaagga ttcttaaagt tttttagccc atttttatta gctattttac ttgctttact
     3421 tttaaatcca cttgtgatgc tttttgagat aaaattcaaa gcacatagac ttttagccat
     3481 ttttttatct tatatattta taggttttat tttagccttt gccattaggt tattaattcc
     3541 atcaatagct aatacattaa atagattgat aaatgaaatg cctatgtata ctgattatat
     3601 agatagtttt atagaaaaaa atatgtcaaa catatatttt ctaaaaactt taattcctca
     3661 tatacaacat agtttagata atttattaaa agaagcaagt aattttgttg gtaaaattcc
     3721 taaaaacttc ttaatctata cacttagtat atcttctatg ctatttaata tgacaatggg
     3781 atttatacta tctatataca ttatatatga caaagaaaaa attgcattgg gatttaagag
     3841 atttctatat tcttctactg ctagaaacaa ggcagataac attatagaat tttttaggac
     3901 tactcatgat attttctatg attatttact tggtagaata ttagactctc ttattattgg
     3961 tataattgca tttttaggat ttcaatttgt tatcagaata gaaaatgctt tatttttagc
     4021 ttcaataata ttcttaggta atataattcc ctattttggt ccttttattg gtgcaatccc
     4081 tccaatagcc atgactatat tatatagtcc acaaaaaact atatgggtca ttgcatttct
     4141 atttatattg caacaattag atggaaattt tatagaacca aaagttatgg gtaatcaagt
     4201 tggtatagga gctatatggg taatatctgc tattttggtg ggacaatctc tatttggttt
     4261 cataggagtt tttctttcag taccaatagc tgctgttgta aaaacttatg ttgataaata
     4321 tatagataat cgtttacaat agcttatctc tactgtgact ttaattttta gtttaaaatt
     4381 taactgttat ttattaaatt atttctcaaa aaatatctct tagtaagaaa aaattgctaa
     4441 gagatatttt ttataatata taatttgttc attaaattta tgcatatatt ttatacttat
     4501 tgattatttg agttttgaga atttccacca ctatctgaac caccagtagt atcttgtgga
     4561 gttggtgctg gtgttggatt actattattt ggcttttctt gattttgaga agaactgtta
     4621 ctattgtcag acttattact atctgatttt ttatcattat ttttagaact agatttatta
     4681 tttttactac ttccactata agaagatttc cttgcatctg attcaactct atacctatct
     4741 tctccagccg tatcttttgc ctttttcttt ctttgttcct ctgcttcgtt ttgttctttt
     4801 tctaatttag ttaactcttc tttcttttta gttgcctctt ctttaataac agaggaacca
     4861 tttttgattt tctctataag tttaagttcc ttgattgcac cctcataatt ttttaattct
     4921 tcaaactccg tcatatttga cattctcata gcttgcatat acatagctct tgcattctca
     4981 ttagtactat cttcttccag tgcagaggat aatgattcca tagctttttt atagttatgt
     5041 ttttctaaat atgtttttcc ttgctctact aaatttattt catctttttt attaaatgaa
     5101 catcctacaa gaaatataga taatatcgat attaataaaa ttactcttcc tctcattaaa
     5161 tccctccttg tcatatactt taaattttat cataattata aagtttttaa aatattttat
     5221 atttattaca agaaatttgt tagtaaaaca aaaaataagc agatatgcta cgaacgatac
     5281 aataaaccaa aaattaattt agagatacat atcctagcaa atctgctcat aataaacttt
     5341 aatatttaat ttttattata tacttctcca ttttatatct ctaaagctaa taagtcctca
     5401 tagctttgtc tcttacaaat tatcttatca tttccatcaa atactgatac tactgctgct
     5461 cttggtattt tattataatt tgaagacatt gaatatccat atgcaccagt tgatgttgtt
     5521 ataagtatat ctccactttt aatatccatt atgtttatat ctccaattaa tatatctcca
     5581 ctctcacaac attttccagc tattgttaca tgattcatag cctcatgatt aattttattc
     5641 acaatactac actcataact agcttggtac aacgaaggtc ttacattatc tgtcatacct
     5701 ccatctacac ttacataaac cctaacatct tttatatctt ttatagaacc tactgtatac
     5761 aatgtacttc ctgcatttgc aactattgac cttcctggtt ctattaccaa tgtaggtact
     5821 tctattccaa gctctttaca tgaagtttct gctttagtga ttatggtttc acaaaactct
     5881 tttatagttt taggtttatc tccttcgcta taataaacgc caactcctcc acctaggtca
     5941 atttctgtta gttgtatgtt gaatttttct tttatttctt ttaccaagtt catcattata
     6001 tccactgtat ctatgtatgg ttctacatca aatatttgtg aacctatatg agcgtgaaga
     6061 cccacaagtt taatattttt atattcactt aatttttcta ttgctctaaa taaatctcca
     6121 tttactaaag caaatccaaa tttagaatct atctgtccag tttttatata atcatgtgta
     6181 tgagcttcta taccaggagt tattctaaag tatatctctt gagttttacc tttatcttca
     6241 cataatgctt caagcaaatc taattcataa aaattatcca ccacaaattt acctacacct
     6301 aaatctaatc ccatgtttat ttcttcttta gtcttattgt ttccatgaaa gaaaactttt
     6361 tccataggaa aatttgattt ataagctgta tataactcgc ctcctgaaac tacatctaaa
     6421 cacatttgtt cttcatttat aagattacac atgtaaagag gtaaaaaagc tttccctgca
     6481 taagcaacct tattttttcc ctctctagcc ttaaaatatt ctacatattc tctacaattt
     6541 tgtctaacta aagcttcatc aaatacataa agtggagttt gatatttttt actaagttct
     6601 aaacaactca ctcctccaat atataattca tcattattta cagtcatagt tccatgaagt
     6661 ttcataatag cctccccaaa ttttatatat taaatacttc tgctattttt tctatagcta
     6721 cttgcttatc atcagaattt atagcacaag ttatacgaat ctctgatgta gttataagtt
     6781 ttatcattat accattttca ttgaatatct taaatacttt agcagcaact ccagaagtat
     6841 ttttcatacc aagacctact aaagaaaatt tagtgatatt attatcaatc actacatgtt
     6901 cttcatctgt atatttagat actatctttt tacattctcc caactcttct tttggaactg
     6961 taaatgatac acttatctta tctaaaatag gtgcagtttg gcttatcata tctacactta
     7021 tacctatagt tgctatatct tcaaataagc tagatatatt ttcagcttta aaatctttta
     7081 ttgttataga actgtcatca tcactagtag ctaatcctgt tattacttta tcctctaatt
     7141 tcatgtcttt tccccctctt atatatgttc ctttttctgt accacatgta cgtccgacat
     7201 agatttcaac accatatttt tgtgcaagct ctatacttct tgaatgcatt acttgtgctc
     7261 ctaaactcgc taactcaagc atttcttcat attcaatctc atcaagttta ctagcctttg
     7321 aatattttct tgggtctgta aaataaattc catcaacatc tgtatatatc tcacattttc
     7381 catttaattt aaccgcaaga gctacagcag atgtatctga accacctctt ccaagagtgg
     7441 ttacatcacc atcttcgttg attccctgaa atccagttac tatcacgaca tttccttcat
     7501 ctaaactatt tttaattctg tttacgttta tatcatcaat ttgagacttt ccatgaagac
     7561 cactcgtttt tatatttaac tggtaagcat tataacttat agctttacat ccaagtgcat
     7621 ttaatgctat tgataataaa gatgctgaaa tcatttcacc agtagacatt aaagcatcta
     7681 attccctctt actaggttca ttactcaatt cctttgctaa agttatatat tcatcagtgg
     7741 attttcccat ggcagacaca actattacca tttgtggatt ttcttttctt cgttctatta
     7801 tattttctgc tattgatttt attttttcag tatctgctac tgaacttcca ccatattttt
     7861 gaacaattat actcatgctt tctccccctc aagctaaatt ttgataaata aaaacgccca
     7921 aaggtatact ttggacgtgt aaatttcata gaccaagtaa ccttgtagct caccacttta
     7981 aaagtgacag ccttatgcat attctgcata agtccagaaa atttgtccgt caacaaaatt
     8041 tcttcggcta tatacccttt catcaattat caacgcttac cagctcctat tgaatactat
     8101 tgaatacagc tacctctacc ctaggctcat tatttttaat taatttatta atatagtttt
     8161 atcatattct atataatatt gcaacaatta ttttacaaaa tgtggcaaat cgatagtttt
     8221 cttttctaaa gttagcttat atacaattaa atagtttatt taatcctaaa tctataaaat
     8281 ttatgctata ctcattatca tatctctcta aatcatttaa ttcggataga ttatctggtg
     8341 taactaccaa aacgtttggt actttaaaaa atggaattgt agatttatct atttttttag
     8401 aaagattttc gtatttagaa atgtctattt cattatttaa gtcaacatca actaaaactt
     8461 gctttatatt accaaattgg tctgtatatt caataaataa atcgtatttc acatcatcta
     8521 cactaacatt tcggtaaaat ctttttacat cacaacctgc agtattgatt ctaacaacta
     8581 attctgatcc tactagagcc tttattaaat catctccctt aaaaagttta ctaccgttta
     8641 aatagtatac ataagagagg tctttataat tataataatc cacatcacaa ggatattttt
     8701 ttagtgtata ttcactacac atttttctca aagttttttt aaaatttttt ttattgtatc
     8761 ttttttggtc tccataaatt tttctaaatt gagactctgt aacacatcta accctgctaa
     8821 ttaaaagtaa tatctctttt tccatattcg tcatagtaca ttctccttga agtattattt
     8881 gcaaagttgt actaatatta tattaatttt atgacattaa atttacaaag aattaaaata
     8941 aaatagctaa tttttataga attaaattct ataaaaatta gctatcacta tgttaaatac
     9001 tattatcaat ctttttattt aaattataca ttaccttgat tttcagaatc tttggaatct
     9061 gtattttcat cagttcctgt tttttctttt gcttttttat cttcaaagtt tgcaatattt
     9121 aggttatcaa attctgacat ttctattaca ccagattctt cttttgaata cgatattttg
     9181 actttatcac caacctgagt caatggcaat tcgctagata cttttgaagt agccctaaat
     9241 attatatctt tatttgaatc taaagttaca taataattag tgttaccacc tcgcacatct
     9301 gggcttattc ttgtcactgt gccttctaat acctcatctt ttaaatcatt atcaagtttt
     9361 aaatcattac ccttagattc taatgcatcc ttatagtttc ttaatgcttc attcttatct
     9421 tcacctattc caagtacatt ataatcttca acagatacaa atgcaactct cttaacaaga
     9481 ccagccttat cttttaatga tgatacatat gttggctgac ccaatatatt atacattaca
     9541 gggaacgtcg cttcataatt tttttcttga acattacctt cagctgattt cattgcagcc
     9601 gtttcagtag ctcctggttg tttatataat ctagcttctt ttgttctaga atcaactaac
     9661 ataaatccaa ttgtagattc atctccacct gaagatgtta tacctgtata ccaataagac
     9721 ctgttatcat tgccataaac tagtgatgta ccttctgttg gtactaaaac tcccttttct
     9781 gatataacag agtttaaaaa tccattaaca taaacacccc agtctttaat ttggtctgtt
     9841 acaaagcttt gtggttgtat tctatccacc catttaggcg tgtttttaac atcataaaca
     9901 tttatttttc cagtttctgc atcaacagtg gctattcctg ttgcatttgc tcctccatag
     9961 ccaattttat gttcatataa acttacaacc caataaggtc ttccttcatc atttatttca
    10021 agagtgaaat ctgtcatacc aacatttaca ataccatgta tgtataaatg tctttgtaaa
    10081 tcctgatgta agtaggcttc tggttggtaa actatcttta ttggctttcc atctatttct
    10141 tgaactaatt ggacgtcttg aggattacta gctgatactt ttacataacc acttgtacca
    10201 cttagagatg ttatccattt aattatgtct ctgtgaacaa gaggcgctac ccagtacaac
    10261 tctccatcta cattttgtat atgaaatttt cctaatttgg atacactccc tattgcagga
    10321 acttctccaa gctttttgtc acctaatttc attgccatat cttcatctac aagacgaatg
    10381 tcatttacac tgacagggct aatgtcatca gtaaatttac tttcagttac ttttcccaat
    10441 agttctctat atgattttgc atgaagtaca ggtgtagaag ttataaaggg aactactaca
    10501 atatacacaa gcaaagctat tgctattgaa aaattatatt tagccatttt agatgctctt
    10561 tcatttctat ctaacatcat atctagtatt cctgctacaa caaagaaaat tattcctact
    10621 gaaaataaag atgtaaaatc taatcttagt acaggtaatt taataaatgc ataaattatt
    10681 acaattatta atgcaactcc atatgtttta agatatcgtt tcatttaata ctcctctcta
    10741 aaaaatgtta ttattactat tatatccata tatttacaaa aaataaatat ttatcatatt
    10801 tattatatat taagatatct ttatatattt atagttctgc ttattcaact atatttaaca
    10861 ttatacgtgt atgtataaat actttttata cactgtttgt actatccatc ccgcacctaa
    10921 aggagtggga tttttgcact attctgtatt atatatatcc aaaaatatta taaaaataca
    10981 aatattagca gaaatttaaa aactgaagaa agtattctaa ctaagattta caaattctta
    11041 atcctatcga agttaaacta ctatcttcag cctaattatc tagcaatatt tttttatatg
    11101 aaaaactcta aatcaagttt ttaaatgttt gcgatttttg atacataaga atgttgtcta
    11161 gaattatatt ctgataataa accttcatac tctaaggtta agccagataa attataaaaa
    11221 tcatttggcg ttacttcaaa tgcttgttta tttaaaatgt ctatctcact tttttctaac
    11281 atgtcagcaa caaaatttga acatacatat ttatattcag attgtctctg aatattcatt
    11341 agtaaatata ttaatgccat tgtatcgtaa tagtaatctt ctctataatc actaattaat
    11401 tttatatttt tatatagatt ttcatattgt aaattatcta cttctaacga atatacccta
    11461 cacacagtgt tttttcttat agcatataat ccttgattta tattttcttc aacaaatcct
    11521 ccaataaatg gattccttgg atttagcctt ccaaaagaat acattggttt tagattttca
    11581 tttaatgata ttgacacatg tgtatacagc tttttactta tattccttat taagtaagat
    11641 aatatagttc ctgtatatgt tgttacaata tagactttat tcatcatttc cccccaatct
    11701 agtaactaaa taatattata cacttacaat ttaatatcat aagatattct aacataataa
    11761 atgtggtttt acaaattttg attttaaggt actttaatat tatataatat aataaaaata
    11821 taaatataag ttttctatat ttttaaccaa cagatgtttt cttcaaatta atcagatgat
    11881 ttagtatatc ttgaaccttt ccagagtcct ttaaatatcc taatgcccca tttatttgtg
    11941 attttaaatc tatttctact tccatatcca aatcaacatt tccttttttt atagatatat
    12001 ttttaagtgt tattggataa agataacttt tttccaaagt aatcttattt ccattaacct
    12061 caaatggaac ttttttattg tagttactta atattttttc tagcatttta tcacttagtt
    12121 taaattttcc aattttcaca ttctcaagac ttacaactaa gtttccatcc tttaaagtag
    12181 gtctcaattc aagttcatat tgactattta ccaaaccaaa taccttatat ggtcctgcta
    12241 cctttatttt accatttttc atttcaacaa aattattttc aagttcatta attccatgct
    12301 tctgcatcaa tgtatatatt aaatttttaa actcttcctc tgaaacagat atttttccaa
    12361 ccattctaag tggatttttt actacctcca tagaatttat atatgagcct tttgataaat
    12421 attcttcatc tatgatttta ttattttgtg aactaacatc atatctttct tttggtgtca
    12481 agatatatac aacaattcct acaagtacta aaacaataac aattaaactt aacaaaatct
    12541 ttgcaacctt tcccataatc gtctccttta caaatctgtc atcagattta aaataaattt
    12601 agataactaa cttcacataa tattcttaac aatatacata ctataataca gtcttttaaa
    12661 aattaattca accaatctaa tgttttgtaa ataaactgta aaaacatgtt tttagtataa
    12721 aagttaatat tttgcataat actcttaatt acacctttat ttttttctaa tcttggatta
    12781 aaattaatat tatgcaatac agtgtagtgt tctgtattat aatcaaatta aataggaggt
    12841 atagaatatg tcaaatgaaa cgaactcatc taactttata aagaatatta ttataaacga
    12901 cttagaaaca ggaaaacatg acagtatcat aactcgtttt ccacctgagc caaacggata
    12961 tttacatatt ggtcatgcaa aaagtatatg tcttaatttt ggattagcta aggagtttaa
    13021 tggaaaagct aatttaagat ttgatgatac aaacccatta aaagaggatg ttgaatatgt
    13081 agagtccata aaagaagatg taaagtggtt aggatttgat tggaacgagt taaattttgc
    13141 atctaactac tttgatgaaa tgtataagag agctttaata ctaataaaaa agggtaaagc
    13201 ttatgtatgt gatttgacac aagaggaaat gagagaatat cgtggtactc taactgaacc
    13261 aggaaaagaa agtcctcata gaaacagaac tattgaagaa aaccttgatt tatttgaaag
    13321 aatgaaaaat ggtgaattta aagatggtga aaaaacatta agagccaaaa tagatatgtc
    13381 ttctccaaat ataaacctta gagacccaat tatatataga atatctcatt caacacacca
    13441 taatacagga gataaatggt gcatatatcc tatgtatgct tttgctcatc caattgaaga
    13501 tgcaattgaa ggaataactc actctatatg tactttagag tttgaagacc aaagacctct
    13561 ttatgattgg tttgttaaag aatgtgagat ggaaaatata cctagacaaa tagaatttgc
    13621 tagacttaat ataaataata ctgtcatgag taaaaggaaa ttaaaacaac ttgtagatga
    13681 gggtattgtt gatggttggg atgaccctcg tgttcctaca atatccggaa tcagacgtaa
    13741 gggatatact gcagaagcat tgcgcaattt ctgtagtgaa ataggggtat caaaagttaa
    13801 ctctacggta gatagtcaaa tgcttgatta tttcctaaga gaaaacttac aaccaaaggc
    13861 tcctcttact atgggagttt taagaccttt aaaacttatt ataactaatt acccagaaga
    13921 taagattgag atgcttgaaa tagagaataa tgctaaagat gaatctcaag gaaagagatt
    13981 agttcctttc tctagagaat tgtatataga acaagatgat tttatggaag aacctgttaa
    14041 gaaatatttt agatttttcc caggaaatga agtccgttta aaaggtgctt attttgtaaa
    14101 atgtactgat gtaattaagg atgaaaatgg aaatgtagtt gaaatacatg gtacttatga
    14161 ccctgaaact aagagtggct ctggctttac aggacgtaag gtaaaatcta caatacattg
    14221 ggttgatgct aaatcagcta tcccatgtga atttagatta tttgaaccat taattcttga
    14281 tgatatacct gaaaatgaag gtaaacattt cttagaacaa ataaatccta attcattgga
    14341 aatattacaa ggttttgttg aacctacaca gataaaagat gctaaacctt ttgataaatt
    14401 ccaatttgtt agaaatggat tctttagtat agataataaa tatacaactg atgaaaaatt
    14461 tgtatttaat agaatagttc ctctaaaaag ttcttttaaa ccaggtaaat aatcttacaa
    14521 tcaaaaaatg aagacttaaa atataaatta cttctactat aaataaactt agttagaagt
    14581 aattttttat ttgagtcttc atcatttact ttaaatgatt aacttttttc actacagatt
    14641 cccatgactt ctattccatc ttttatgcat tctatgttaa gaggaaaatc tggtcctttt
    14701 tctccgtcaa tatctgttat aagtgaatct tcacattcta tatgcacctt tttagtttta
    14761 aagtatagta tttcatttcc attatattga tctaaataat cacctctaag cacacttatc
    14821 aaaactggta ttgattttgg tattggcatt cctttaaaaa taattacatc caaatatcca
    14881 tcatctattt cagccttata tgctagattt atatttcctg ctgttttgcc attaaaaatc
    14941 aacataagat acatatctcc atcataatac atttcctcag aagatacttt tatcttaaat
    15001 ttcctcatat acaatgcttc ttctattccc tttatataat aagaaattct tccaaatgaa
    15061 ttttttaagt ctgtgtttat cctttgtgat acatccgtaa acataccagc acttgcaaca
    15121 tttataaagt acttattatt gactttccct atgtctattt tctttggttt tgaatttatg
    15181 atttcattta tagcttcttt tatatcaaat gaaatttgaa gagcatttga aaaatcattt
    15241 gcagttcctg taggcaaaat tccaattgga atttttatgt ctaattcttt cattgcattt
    15301 actactaaat ctacagtacc atcaccacca gctatcaata tgtgttcata agaactatca
    15361 acttccttaa atgcattctt tacaggttct ttaatagtta atctataggg tatcaataaa
    15421 taattttttt cttgatataa ttctatgata gtgtctaaat ttgataatat ctttttttca
    15481 cctgaattag gattgtatat aagttttact tttttcatta tttctcctta ctcattttat
    15541 tcttttagta tccaaaatct tcatttaaaa aaatcacatg tattctttct ggtgttaatt
    15601 gtctttttat aagtgtataa ctacagcata ttcttcctgg acttgaacag tctatacata
    15661 taccagtagt cttacatcca gtatttgtac ttaatctttt acaattggct ggagcagcta
    15721 ttgtttttgt tctttttata gcttcatcta catctttaac tattttattt actcctgcta
    15781 taactattac tttatcaggt ccatatatca tagcagcaac tctattccca ttcccatcta
    15841 aattgtaaag ttctccatcc tctgttatcg cattagtact tgtaaaataa gcatctgcag
    15901 aaaatgactt tctatatatt tctttcattt cttctggttt gatatctttt gcatatctat
    15961 caagaaaatt atatttttct cttataaaat caatcactcc tgtttcaaat aaggtcatag
    16021 aacctccaca tcctactaga gaacctgctt taactatttc ttcaattttt ttaagaagct
    16081 cttctttgtt acttactaaa taccctttca tattattgtt ttccaaagat tttattgttt
    16141 tttctattct tttttcatta agccaattta aattttgatc cattttaact tcccccttat
    16201 ttttaatatg tacttaatta tttataaact ttattttctt tataagttta ttttagtaca
    16261 tctaaaaaaa aatacaatat aaaacttaaa tagttttaca taattttttc caaaataact
    16321 tactcaatca aaaaaggaaa gtagatgtac tattctactt tccctatatt gtatgtagta
    16381 tttattgcct aaaatctata tattaattat atgtttcata ttatataata tcacagttaa
    16441 ttaaaatgta atactatctt ctttttaaac atataaattg tattattaaa tttaatatat
    16501 ccaacttcaa taaatcttat taatttgatg aagaagatgc tatagctgca cttgttgctg
    16561 ccattacaca tgcaatttga atagcaacaa caatatttaa aaatatatta ttagttatag
    16621 agcctatatt attctcattt cgtatcaaat ctgcataaat tgaagctaca atagcagaac
    16681 taatcattac tctattactt tttcctaaag accaatttcc aaagcctttt tcttctttaa
    16741 gtttatttga aacatttttt atctcttcta ttatttcatc ttctctataa tctaataatg
    16801 aaattgctcc tattattgga tatccataat aattcatttt acaatcattt tctttaaatg
    16861 cttttttaag ttcaatagtc tttttacatt taagcatagt tctatcatca ctaaataaaa
    16921 gaatttggga taatgcttgt aaatcatttc ctttataaaa accattttca tttagaaatt
    16981 cataacattt ttctatgtat tctaaatctt catctaaatt ttttgaatga attgcaataa
    17041 gtgctatatt acaatagtca tcactagaag ttagaaatgg atgttttttc ctcatgtaat
    17101 catatattat tttcattttt gatatacatg taagataatc cattttctct ctattttcat
    17161 aaactattga tgctgtaagt ggtaaatatg tatcgcccca aaacttttca cttttaagtt
    17221 ctttgtatat atctaaaatc atcttaaaac tactttctgg atttgattca aacgaaagta
    17281 gtgttgccat ataaaacata ttatatcctc taaaattaga gaataatcca gtattttttt
    17341 taataagctc tattcgttct tccactaatc taggacttat tttcttgttc ttaagggtaa
    17401 atgcaagtgc acaactatgt tgtatcaatc ccatttgcca agaaccttta acttcattta
    17461 atgctttgta attttctatt aataagttta cttttccatt tataaacgat tgttccatat
    17521 tgccctccta gtaatatatc tcattgtact aatagtttta tatttattat atatatatta
    17581 aatactacaa tcaatacata ttacttcaaa gaacatcatt cttcaacaat aatgtagcct
    17641 tttttgtaat gtcttcccat attattgact ctatcatagt actctgattc actttcatta
    17701 ctccatttgg gcacaaatac atctattgca ttagaattac taaaatactt actagacccc
    17761 ctatccataa cagtttttaa ttttccatct acaataatct tagttccaaa acttaagtga
    17821 ttgtttgcta caaaaccatc ttctaaatca tctcctgtag cagttatcgc tccatatcca
    17881 ttttcttgat taagacttgt gtaataacta acttcaaaag ttataggtac taacttcttt
    17941 attttaatac ctaactgatt ttgtagtttc tccttttgta ctttcaactt atactcatca
    18001 ctatttttat aatcttccat accttgatta tacttggaat taaagctttt acctgacttt
    18061 actatagtat ctatatttac tatagattct ttacaatgat ctgcatctat ttttgtttct
    18121 ccatttacca ataatggagt taaacataca ctacatacaa cacatgtaat caatgcttct
    18181 ttaagcttca taaattcccc ccttattatt ttgatatatt agcatattta atattatatg
    18241 tctacattta gatttaaata ccacacccat ttgctttaag aagttgtctt atatttaatt
    18301 cacctta
//
LOCUS       DAEPID010000077        17749 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.077, whole genome shotgun sequence.
ACCESSION   DAEPID010000077 DAEPID010000000
VERSION     DAEPID010000077.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 17749)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 17749)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..17749
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.077"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            <1..845
                     /locus_tag="KR257_003000"
     CDS             <1..845
                     /locus_tag="KR257_003000"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893277.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=3
                     /transl_table=11
                     /product="radical SAM protein"
                     /protein_id="HBH0031671.1"
                     /translation="RSMPYKWDLNIYRGCEHGCKYCYAIYSHKYINSNNYFEEIYVKT
                     NIVEKLERQLKSSKWKKEVINIGGVTDSYQPIEADYKIMPEILNLLIKYKTPAIISTK
                     SDLILRDYDLIDKLSRITYINVASTITTVNEDTQRLIEPNGVDSMRRFKMLKEFRKTN
                     ASVGLHIMPIIPYITDDFDNINSLFRHAKECNVHYVLPGTLYLRGITRGVFFDFVKKE
                     FPELFDKLSILYSAGSLNREYKNQLYKMVNELRYKYSLSSSYSKIMKEKLKNSGDVQI
                     SFFD"
     gene            1215..2027
                     /locus_tag="KR257_003001"
     CDS             1215..2027
                     /locus_tag="KR257_003001"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430250.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="HBH0031672.1"
                     /translation="MYLERPELYKQSEINFWDDEYISKQLLKAHLDTNFEGASRNFNF
                     IEDSVNWIVTVANPANYPKLLDLGCGPGLYAEKFAQKGYKVTGIDFSKRSINYAQNRN
                     KETNLNINYLFQSYLNMNYNEEFDLATLIYCDYGALSTENRRLLMEKIYDSLKPGGKL
                     ILDVFTINKYNNFEEIKYWEINEDGGFWSNEKYMCLQDNCKYNDYNTLEQTLVITEKD
                     ENVFYVWNHYFSKESFLLEVENIGFKSVEFFSNVKGEAYSDDSMTMGLVLQK"
     gene            3075..3836
                     /locus_tag="KR257_003002"
     CDS             3075..3836
                     /locus_tag="KR257_003002"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896901.1"
                     /note="N-terminal region resembles flavodoxins. C-terminal
                     ferrodoxin region binds two 4Fe-4S clusters; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="EFR1 family ferrodoxin"
                     /protein_id="HBH0031673.1"
                     /translation="MIGIYFSGTGNSRYCVEKFLQEYDITANSYSIEDNELLQHINNH
                     ENIIFSYPVQYSNVPKILKDFIINHSTLWNGKRVFIIATMALFSGDGSGVLSRILKKY
                     GAITVGGLHVKMPDSIGDEKVLKHSLEYNRKLVIKAEKKVTKAAKKLKHGSPPKEGLG
                     FLSHIVGLFGQRLYFINKTNMYTDKLKINTEECIVCGKCVNLCPMKNLVIKNCMIVAN
                     GQCTMCYRCVNNCAKKAITLLGKKVVEQSNIKKYM"
     gene            3901..4683
                     /locus_tag="KR257_003003"
     CDS             3901..4683
                     /locus_tag="KR257_003003"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430254.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PhzF family phenazine biosynthesis protein"
                     /protein_id="HBH0031674.1"
                     /translation="MEYYIVDSFATKLFKGNPAGVCVLDRRIPLELMQKIAEENNLPE
                     TAFVVKGKGNYELRWFTPKAEIDLCGHATLAAAYVISNFIDVNVKRIDFFTQSGKLEV
                     TRNGNLYEMIFPEIMPIEIELSPQQANLIGCVPSAVYSSRDLILLLNSEQEVINYKPN
                     YAQLRKLTDWLGIIITAQGSNTDFVSRYFCPELDSEDPVTGSSHCNLIPYWSEKLGKH
                     KMVAAQLSNRGGIIQCEVLKDNTVKISGEAVLFMQGTIKIDI"
     gene            4950..5369
                     /locus_tag="KR257_003004"
     CDS             4950..5369
                     /locus_tag="KR257_003004"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861328.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YjdF family protein"
                     /protein_id="HBH0031675.1"
                     /translation="MDKISGKLTVLFEEPFWVGIFERQDGKKYEACRVVFGAEPKEVE
                     VYEFILERFFSLDFGSIKLEKNVTKDNIGYKRMQRKVKKEQEKETIGTKAQNALKLQY
                     EERKQDRKNLAKNRKEEEKERLFNLKQEKRKAKHKGH"
     gene            complement(5472..5738)
                     /locus_tag="KR257_003005"
     CDS             complement(5472..5738)
                     /locus_tag="KR257_003005"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896904.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1294 domain-containing protein"
                     /protein_id="HBH0031676.1"
                     /translation="MKNFILIYFIVINSIAFFSMYIDKKRAIRNEWRIKEATLMSIAV
                     IGGSIGSIIGMYSFRHKTKHIKFTFGIPFILFLQFLLVYFYILK"
     gene            5965..6666
                     /locus_tag="KR257_003006"
     CDS             5965..6666
                     /locus_tag="KR257_003006"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454365.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0031677.1"
                     /translation="MKFIVEKEVFDKLENVCFGVVVAKGIDNTKEIERISNLLDISID
                     RVEDYFKDKKVKESEEIIPYREAFRSLGMNPNKFMSSIEAMTTRVAKNKKLPHINPIV
                     DLGNSISLKYLLPMGAHDMDFRNDDVYVRFSKKGDKFVPFGETDVELMEEGELIYSVG
                     DMVKTRRWIWRQGEEGKITNSSKNIFFPIDGFTDANLDKVMSAREELAKLLKEIFNCE
                     IKVGFVDKDNPEMEI"
     gene            6748..7356
                     /locus_tag="KR257_003007"
     CDS             6748..7356
                     /locus_tag="KR257_003007"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423726.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NUDIX hydrolase"
                     /protein_id="HBH0031678.1"
                     /translation="MKKTIIKNVNPMIENKFIGLFEIEYKNKLDEDKVWMVASRKSSE
                     QLKNIYLKNEEDSVDAVVIVGLHKSSKKLILIRQFRVPINGYIYELPAGLVDEGESID
                     ISVERELREETGLTLLEIKKNKSIDKVYLSPGMSDESVAFVYCICDGDITDEFLEPDE
                     EIEALLISQEDAKEILQSNHKIDTKAFLILQMFVSLGAKLFE"
     gene            7680..8144
                     /locus_tag="KR257_003008"
     CDS             7680..8144
                     /locus_tag="KR257_003008"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003439554.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4624 domain-containing lipoprotein"
                     /protein_id="HBH0031679.1"
                     /translation="MKKLVIILISIISMVSLTACKKSNESKYNNLNNKESGQTTIEMD
                     LDKNYDTSDPFVNARLFCVSNDIDVLDTEISFKMDGDSGIVEIKDNKTDETLWSNTWH
                     GSVDNDTFTISLSNIQKEKEYAICFTGIKINHAVVKVTFESNLVKEKEKPSK"
     gene            8781..9797
                     /gene="gap"
                     /locus_tag="KR257_003009"
     CDS             8781..9797
                     /gene="gap"
                     /locus_tag="KR257_003009"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011948756.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type I glyceraldehyde-3-phosphate dehydrogenase"
                     /protein_id="HBH0031680.1"
                     /translation="MKIKVGMNGFGRIGRAVLRIAQEELGDNIEIVAINARATTESLA
                     HLFTYDSCYGTFRGEVEAKDEDTLVVNSKEIKILRYNDPEELPWKELGVDIVIESTGL
                     FTQREKAEKHIKAGAKKVIITAPGKNEDITIVIGVNEKEYDNEKHNIISNASCTTNCL
                     APFAKVLDEKFGIVKGLMTTVHSYTNDQRILDKSHKDLRRARAAAESIIPTTTGAAKA
                     VSRVLPQLEGKLNGFSLRVPTPTVSLVDLVCELKENVTSEQVNSVLKDAAEGELKGVL
                     GYCDKPLVSIDYKGDSRSSIIDALSTMVIEDNMVKVVSWYDNEWGYSSRTVDLVKYVA
                     EKLK"
     gene            10192..11361
                     /locus_tag="KR257_003010"
     CDS             10192..11361
                     /locus_tag="KR257_003010"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902759.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0031681.1"
                     /translation="MEKLTDRRQVKAVSMETFIFLILLVVGFGYVGSIMGAGMMFKVI
                     MSTAHALLLETVFLIMAMAVLAGALSALLSEFGVIALINKIFAVFMKPLYGLPGASIA
                     GAITTYLSDNPAIIPFAKDKTFTQYFKQYQVPALCNLGTAFGMGLILTTFMISQGTEY
                     VLPALIGNLGAIIGSVISVRIMLTFTKKFYKYNPEEDKATGTLEKKDEFREIREGNVF
                     QRALDAILEGGKMGVDMGMAIIPGVLVVCTLVMLLTFGPSTDPVTGQEVYTGAAYEGI
                     KLLPVIGDKLGFILEPLFGFTSPEAIAFPITSLGAVGAAMSLVPEFIKSGAITPNDIA
                     VFTAMGMCWSGYLSTHIGMMDALNARQLAGKAILSHTIGGLCAGAAAHFIFTLVG"
     gene            11741..15994
                     /locus_tag="KR257_003011"
     CDS             11741..15994
                     /locus_tag="KR257_003011"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861332.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="2-hydroxyacyl-CoA dehydratase"
                     /protein_id="HBH0031682.1"
                     /translation="MDELFHIGIDVGSTTVKVVVLNNSNNIVHKEYRRHYSDVKKSVK
                     EVLNGIYEKLGDINTTIIITGSGGIGISKKLGVKFVQEVISSTKSIEYFHPETDVVIE
                     LGGEDAKITYLSGGIDQRMNGICAGGTGAFIDQMASLLKTDASGLNELAKGYNVIYPI
                     ASRCGVFAKTDIQPLINDGANQTDIAMSIFNAVVVQTVSVLSCGRKIEGNVAFLGGPL
                     YFLSELREAFKRVLDLKDENIIFPENAQLYIAIGAGLLSVDEDNIQLKSLIEKLDSIK
                     NIEDGEVNLLEPLFKDKNEYEEFSRRHEKEKINYVDINSIKSNCYLGIDAGSTTTKAA
                     LIDEDGRLVYSYYNSNEGNPLKTTIKVINEVYDILPKNIKILSSTVTGYGEGLIKKAL
                     KIDNGEIETIAHYKAAKFFNKDVDFILDIGGQDMKCLKIKDGVIDNIILNEACSSGCG
                     SFLETFASSLSMTIEEFAHEGIYSQNPVDLGSRCTVFMNSRVKQAQKEGASVGDISAG
                     LSYSVIKNALFKVIKIRDLNEIGNNIVVQGGTFYNDLVLRSFEKLIGKNVIRPNISGI
                     MGAFGSALIAKEKYESGYKTSLLSKEELNNIKLEASVTRCKGCSNHCLLTINKFSDNE
                     IFISGNRCEKGEAIYGDKKIGLEKKKPINLFKYKYNRIFRYKPLEKEEAKNGEIGIPR
                     VLNMYEDYPFWFTFFNAMGFRVVLSDRSSKQLYETGITSIASETVCYPGKLVHGHIEN
                     LIAKGIKNIFYPSVTNENKEDSNADNYYNCPVVISYSEVIKNNVENIRNKNINYINPF
                     ISLNDKEKLKKRLYDELSRHFSDIKITKEEVNHAVDKATDEQNLFKMEIQAAGERALK
                     EIKERNMKGIVLCGRPYHIDPEINHGMPELINSLDMAVLTEDSICHLANVQRPLRVVD
                     QWVYHSRLYKAASFVRDKNYLELVQLNSFGCGLDAVTTDQVQEILNEKSKIYTIIKID
                     EGNNLGAAKIRMRSLKAAMFERESKNIDVKNIKVNRIQYAKNNQITNKHTILAPQMSP
                     IHFQFLEKAVNLSGYNIEILKDTDSSVIEEGLRYVNNDACYPAIIVVGQLITALKSGK
                     YDLNNTSVTITQTGGGCRATNYIGFLRKAIYDAGFKDIPVIALSVNGIEDSGIMDNIS
                     LKLINRLFMSVVYGDLLMKVLYRVRPYEKVTGSANALYEKWVDICKSSLVKAKISVFT
                     RNIKDIVKEFDNLEILDIKKPKVGLVGEILVKFHPIANNNLVDILEREGAEAVVPDLT
                     NFFLSCAFNTIYKHTHLEGSRKSRMIGEAFIYITGIYQRVYKKALDKSERFYAPANIK
                     NVAKSTEPVVSLGNQTGEGWLLTGEMVELLNEGVENIICMQPFGCLPNHIIGKGSIKE
                     LKRLYKNANIIPIDYDPSASEVNQLNRIKLMLSKAFKNI"
     gene            16143..16637
                     /locus_tag="KR257_003012"
     CDS             16143..16637
                     /locus_tag="KR257_003012"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430263.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="methylated-DNA--[protein]-cysteine
                     S-methyltransferase"
                     /protein_id="HBH0031683.1"
                     /translation="MSLVYDVYKSKLGNLYILSEDGFIVSIYIGDEKFNNLKNECIKK
                     GIDIKRSKEDLKEAISQIDDYFNGKRKVFNLNIRIEGTEFQKSVYREMLKIPYGETLC
                     YSDIARNINNPKSVRAIGQASKSNKIPIIIPCHRVVGKKDIGGYMGNHSDLKEILLNL
                     ERQS"
     gene            16753..17130
                     /locus_tag="KR257_003013"
     CDS             16753..17130
                     /locus_tag="KR257_003013"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430265.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="monooxygenase"
                     /protein_id="HBH0031684.1"
                     /translation="MCDKVIASKYHEKGFNCAESVIKAYNEEFNTDIPVCLGSGLGSG
                     CGVASLCGAVNASNIIIGYVKGRNHEDESTKAKVYAKDLTTTVRKEYGSELCIDLKKD
                     LVACREIMDFAYDSLKETLKKEL"
     gene            17336..>17749
                     /locus_tag="KR257_003014"
     CDS             17336..>17749
                     /locus_tag="KR257_003014"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893285.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SufBD protein"
                     /protein_id="HBH0031685.1"
                     /translation="MKNLNLLINKLYSKNHNEAYKTFLFLENESLKSNITYCFFDSFL
                     EMIDNENSYIRTRGLLLISANAQWDIDNKIEINIDSILSHIVDKKPSVSRMFIKSIPN
                     ITKYKENLINRIKMELSNADISIYNNNMKPLVEKDI"
BASE COUNT         7229 a         1734 c         3063 g         5723 t
ORIGIN      
        1 aaaggagtat gccatataaa tgggatttaa atatttatcg tggatgtgag catggatgta
       61 aatattgtta tgctatttac tctcataagt acatcaactc caataattat tttgaagaga
      121 tttatgtaaa aacaaatata gtagaaaaac ttgagagaca acttaaaagc agtaaatgga
      181 agaaagaagt aatcaatata ggaggagtta cagatagtta tcaaccaata gaagctgact
      241 ataaaattat gccagaaata ttaaacctgc taataaaata caagacacca gctattattt
      301 ctacaaagtc agatttaatt ttaagagatt acgatttaat tgataagcta tctaggatta
      361 catatatcaa tgtagcatct acaattacca cagtaaatga agatacacaa aggcttattg
      421 agccaaatgg tgtggattca atgagacgat ttaaaatgtt aaaagaattt agaaaaacta
      481 acgcatcagt tggtctacat attatgccaa ttataccata tattacagat gattttgata
      541 atataaattc gctatttaga catgcaaaag aatgtaatgt acattatgtt ttacctggga
      601 ctttatactt aaggggtata actagaggtg ttttttttga ctttgttaaa aaagagtttc
      661 ctgaattatt tgataaatta tcaatactat atagtgcagg ttcacttaat agggagtata
      721 aaaatcaatt gtataaaatg gttaatgaac ttagatataa gtattctcta tcaagcagtt
      781 actctaaaat aatgaaggaa aagttaaaaa actcaggaga tgtacagata tctttttttg
      841 attagtttta tataaaaaaa ttttttttac tatgatgatt aaaatttatt aaaattaaaa
      901 tttattgaca aatataaaat ttaaatatat aattaattca taaaataaaa atatgaaagg
      961 atgatgttgt tcggtgatat ttgatatcat aaaatcgttg atataagtat tgctggaaaa
     1021 gagtgaataa aatcaaattt aataagcaaa caaagtaaag ctatagtttt attgttgtgc
     1081 ttaaaaatat ttggttctat tttactctta tttaaactca tctttttgaa gttaaaccac
     1141 agagtaaact ctgtggtttt tttattttaa aaataaattt taaggagtgg tatgttttgt
     1201 taaacaaatt atgtatgtat ttagaaagac cagagcttta taaacaaagt gaaattaatt
     1261 tttgggatga tgagtatatt tcaaagcaat tattaaaagc acacttagac actaattttg
     1321 aaggagcaag tagaaatttt aactttatcg aggattctgt aaattggata gttacagttg
     1381 caaatccagc taattatcct aaattacttg atttaggttg tggtccaggt ttatatgcag
     1441 agaaatttgc acaaaaaggt tataaggtaa ctggaattga tttctcaaaa cgttctatta
     1501 actatgcaca aaatagaaat aaggagacta atttaaacat aaattacttg ttccaaagtt
     1561 atttaaatat gaactataat gaggaatttg atttggctac tttaatttat tgtgattatg
     1621 gagctttgtc aactgaaaat agaaggttat taatggaaaa aatttatgat agtttaaaac
     1681 ctggaggaaa attaatatta gatgtattta caataaataa atacaataat tttgaggaaa
     1741 ttaaatattg ggaaataaat gaagatggag gattttggag taatgaaaaa tatatgtgtc
     1801 tacaagataa ttgtaaatac aatgattata atacattaga acaaactctt gtaataaccg
     1861 aaaaagatga aaatgtattt tatgtttgga atcactattt ttcaaaagaa agtttcttat
     1921 tagaagttga aaatattgga tttaagtctg ttgagttttt tagtaatgtt aagggtgaag
     1981 catattctga cgatagtatg actatgggat tagttttaca aaaataataa tttttttaaa
     2041 atgaataaat aaaaacttga aacctttaac aataaaataa cataataaaa gcttacatat
     2101 tgaaaaatgg aaacttttat gttattttta gtacattaca aatttgctta tataaaaatc
     2161 aatacttgaa ttattatttt tatgtgaaat ttatctatag tatattttta taaacaagta
     2221 atgttattaa aattaagtat gtagttaaaa gtgtatagca aaaaggctgt tatattaatg
     2281 ttagaggttc agggaaaata tataaagcaa agtatttaca gataatgtag attgcacagc
     2341 tataagttag ataatagaat tatgtaatca agaatttaca acaaagtata agataaggat
     2401 aatgctaaat tgccatacag gtgctagatg tgtaaatgga tttaattaat actattgata
     2461 aagtgcaaca agcacataaa ccaattgatg agattattaa aactataaga gatatagttg
     2521 acataattaa aatattggaa cttgtttata attttaaatc aaatcaataa tgattaagat
     2581 taaaataata ttaaggcatc aatgttataa gagtacaata taaggagtac tatatagtac
     2641 tccttactta tacatattag gcaataggaa attttttcat agttaaattt tcaagtattt
     2701 tttaggaaac tttataattg agaattaagg gtatagtatg tgatgaactt actgaattta
     2761 taattaggtt atataatgga ataatcatca atagttttac tttagggaaa atatatgctt
     2821 aaggaagtat agcttactaa tattattaaa atgtatattt aaaatgataa aaaaagaatt
     2881 agacaagtat ttagtaaatt gactatgcaa aattctatca agcaggaacc ctatgacttt
     2941 agtcatggga ggttcagtag gtaacttgtt gaattaagtt tatattattt aaataaacta
     3001 cttaatttag ataatataaa aagtcagaat tttaagaata gagctatata atcttagcta
     3061 ttaggagaat tactatgata ggaatatatt ttagtggaac aggaaattca agatactgtg
     3121 tagaaaaatt tttacaagaa tatgatataa cagcaaattc ttattctatt gaagataatg
     3181 aacttttaca gcacatcaat aatcatgaga atattatttt tagttatccg gtgcaatata
     3241 gtaatgtgcc aaaaatattg aaagatttta taataaatca ttcaactttg tggaatggta
     3301 aacgtgtttt tattattgca actatggctc tatttagtgg agatggctct ggtgtgttat
     3361 ctagaatatt aaaaaaatac ggtgctataa ctgttggtgg attacatgtg aagatgccag
     3421 atagtatagg agatgaaaag gtattaaaac attctttaga gtataataga aagcttgtaa
     3481 taaaagcaga aaagaaagta actaaagctg ctaaaaaact gaaacatggg tcaccaccaa
     3541 aagaagggtt aggttttttg agtcatattg tagggttatt tggacaacga ttgtatttta
     3601 tcaacaaaac aaatatgtat acagataaac taaaaattaa tactgaggaa tgtattgtat
     3661 gtggtaaatg tgttaattta tgtccaatga agaatctagt aattaaaaat tgtatgattg
     3721 ttgcaaatgg gcaatgtaca atgtgttatc gttgtgtaaa taattgtgct aaaaaagcaa
     3781 ttacattgtt aggtaaaaaa gttgttgaac agagtaatat taaaaaatat atgtaagaaa
     3841 tttaaagttt tattgaatgt aaattgatgt atattttatg ttagaaagag aggttaaata
     3901 atggaatact acatagttga ttcatttgca actaaactat ttaaaggaaa tcctgctgga
     3961 gtttgtgttc ttgacagaag aataccttta gagttaatgc agaaaatagc agaagaaaac
     4021 aatttaccag aaacagcatt tgtagttaaa ggtaaaggaa attatgaatt acgatggttt
     4081 actcctaaag cagaaattga tttatgtggt catgcaactt tagcagcagc ttatgtaata
     4141 tcaaatttta ttgatgttaa tgtaaaaagg atagatttct ttactcaaag tggaaagctt
     4201 gaagttacac gaaatggaaa tctatatgaa atgatatttc cagaaataat gcctattgaa
     4261 atagagttat caccacaaca agctaatttg ataggctgtg taccaagtgc tgtttattct
     4321 tcaagagatt taatcttatt gctaaacagt gaacaagaag ttataaatta taaacctaat
     4381 tacgcacaat tgcgtaaatt gacagactgg ttaggtataa taatcacagc acaaggaagt
     4441 aatacagatt ttgtatcaag atatttttgt ccagaattag attcagaaga ccctgttact
     4501 ggttcatcac attgtaatct tattccatac tggtctgaaa agttgggaaa acacaaaatg
     4561 gtagctgctc aactttctaa tcgtggtggt ataattcagt gtgaagtgtt gaaggataat
     4621 actgtgaaaa tttctggtga agcagtcttg tttatgcagg gaacaataaa gattgatatt
     4681 taaataagta taataactaa tttattatga aaaataatta attttcttag tgttaacaat
     4741 aataaagtag agttaaaaaa cttgatttca cttaaatcaa tatgatagat gttgatacta
     4801 agattgacaa gcatgattaa aaaagataat atttaatcta taaagataaa aacacagtct
     4861 ggttggtagt ccagacgcag caatagctgt cagtaacctg cctccttggt tgtccgttct
     4921 ttagaaagta atttaaggag gaactagcaa tggacaaaat tagtggaaaa ttaacagtct
     4981 tatttgaaga accattttgg gtaggtatat ttgaaagaca agatggtaaa aaatatgaag
     5041 catgtagggt agtttttgga gcagaaccta aagaagtaga agtgtatgaa tttatacttg
     5101 aaagattttt ctcattagat tttggtagca ttaaattaga aaaaaatgtg accaaagaca
     5161 acattggata caaaagaatg cagagaaaag taaaaaagga acaagaaaaa gaaactatag
     5221 ggactaaggc tcaaaatgct cttaagcttc aatatgaaga aagaaaacag gatagaaaaa
     5281 acctagctaa aaatagaaaa gaagaagaaa aagaaagact atttaatttg aaacaagaaa
     5341 agagaaaagc taaacataag ggtcattaat tttaattaaa tatcttttta ataattgcta
     5401 gaaaaaggtg tataaaattt ttaattttat acaccttaat ttattgaaaa gaataaggtt
     5461 ttatatttca attactttaa aatataaaaa tatactaata aaaattgtaa aaatagtata
     5521 aatggtatac caaatgtaaa tttaatgtgt ttagttttat gtctaaaaga atacattcca
     5581 attatagaac ctatactacc tccaattact gctatagaca taagagtagc ttcttttatt
     5641 ctccattcgt ttctaattgc tcttttctta tctatgtaca ttgaaaagaa agcaatagaa
     5701 ttaatcacta taaaatatat tagaataaaa tttttcacag tcttgcctcc ataaaaatat
     5761 attatacatt ataaaacaag atatttgttt tggaaagtta aatttgtaat tagtacatat
     5821 aaaatatttg ataagaacaa atataatatt aattggaaaa tttaaaaaaa ttaaacaatt
     5881 agcaaatagg gggtatattt ataagacaca aagtgataaa atctatttag aaaataatgt
     5941 aaaataacag gaggataaag caaaatgaaa tttatagtag aaaaagaagt ttttgataaa
     6001 ttagaaaatg tatgctttgg tgtagtagtt gcaaaaggaa tagataatac taaagaaata
     6061 gaaagaataa gcaacctttt agatataagt atagatagag tagaagatta cttcaaagat
     6121 aaaaaagtaa aggaatcaga agaaattata ccatatagag aggcatttag aagtctaggc
     6181 atgaacccaa ataaatttat gagttcgata gaagcaatga caacaagggt tgctaagaat
     6241 aagaaacttc ctcatataaa tcctattgta gatttaggaa actctatttc tttaaaatat
     6301 ttacttccaa tgggtgctca tgatatggat tttagaaatg atgatgtata tgttagattt
     6361 tctaaaaaag gggataaatt tgtaccattt ggagaaactg atgttgaatt aatggaagaa
     6421 ggagaattaa tttattcagt tggagacatg gtaaaaacta gaagatggat atggagacaa
     6481 ggagaagaag gaaaaattac taatagctca aaaaatatat tttttcctat agatggtttt
     6541 actgatgcta atttagataa ggtaatgagt gcaagagaag aattagcaaa attgttaaag
     6601 gaaatattta attgtgaaat taaagtaggt tttgtagata aagataatcc tgaaatggaa
     6661 atataataag ttgttgaata cttgttaaga tattatattt acttaatgat gttaaaaagg
     6721 tattaaaaaa gaaaggtcgt agtaaatttg aaaaaaacta taataaagaa tgtaaatcca
     6781 atgattgaaa ataagtttat aggacttttt gaaatagagt ataaaaacaa attagatgaa
     6841 gataaggttt ggatggtagc atcaagaaaa agtagtgagc aattaaaaaa tatttatttg
     6901 aagaatgaag aagatagtgt agatgcagtt gtaatagttg ggcttcataa aagtagtaaa
     6961 aaattaattt taataagaca atttagagta cctattaatg gatatatata cgagttacca
     7021 gcaggtcttg ttgatgaagg agagtctata gatatttccg ttgaaagaga acttagagaa
     7081 gaaacaggac ttactctttt agaaattaaa aaaaataaaa gtattgataa agtttattta
     7141 tctcctggaa tgagtgatga atctgttgcc tttgtttatt gtatatgtga tggtgatata
     7201 acagatgaat ttttagaacc agatgaagag attgaagcgc ttttaatttc gcaagaagat
     7261 gcaaaagaga ttttacaaag taatcataag atagacacaa aagcattttt gattttacaa
     7321 atgtttgtga gtttaggagc taaattattt gaatagatat atagaaaaga ggttatatag
     7381 aagagtaaaa taataaagtt tattttactt gtgtaaatta taatctcttt ttttatacaa
     7441 taaagtataa ttttgtgtat ttttaaataa gtgatttgac tcttaaattt tcataatatg
     7501 ttataaacca atttaagata ctacaataat taaaattcca aaattattta acatatttgc
     7561 aattaaaatg agaaaatgta aaggctgaat gattgaaaaa tttgatgtaa aatagtagct
     7621 tagtttaata ctatagtttg tagggttaaa aattagaaat tgtaagggag ataaattcta
     7681 tgaaaaaatt agttattatt ttaattagta tcattagtat ggttagcttg acagcttgta
     7741 aaaaaagcaa tgaaagtaaa tataataatt taaacaacaa agaatccgga caaacaacca
     7801 ttgaaatgga cttagataaa aattatgata cttcagaccc atttgttaat gcacgtttgt
     7861 tttgtgtgtc taatgatata gatgttttag acacagagat ttcttttaaa atggatggag
     7921 atagtggtat tgtggaaata aaggacaata aaacagatga aactttatgg agtaatacat
     7981 ggcatggaag cgttgataat gatacattca caatttctct ttctaatata caaaaagaga
     8041 aagagtatgc tatatgcttt actggaatta aaataaatca tgcagttgta aaggttactt
     8101 ttgaaagcaa tttagttaag gagaaagaaa aaccctcaaa ataaattcca gcttttctat
     8161 aacttgatat tcagtacata aaagcagttg atatttatga ttgactgctt tttcttatca
     8221 aaaaggatag gttgtgcatt tttacttgaa atagtttatg cacatcaaaa gttggtgagc
     8281 atgatattgg aaatggtaag catgaaatct tgataataca aggaaataaa tttaagtttt
     8341 caattaagta tatttccata atttagttaa caataagcta attattattt atattttgat
     8401 atataaataa taattgtagc aaattttaaa aaatcatata ttttttgaac taaataaaaa
     8461 tttattttta ttattttaaa ttagaggaga ttcttgaaga tatattattt ttaaaaataa
     8521 gtatagttta aaaattcaaa aaaaagatgg caaaatatgt cccaagggac attgagtaaa
     8581 ataaatgatt tcagcttatt tacactaaaa agtacatact aaatgagggg taaaataaag
     8641 aaaaatgata tactaattgt cttttgataa taaaaaaaca tggaatttga ttatttaatc
     8701 aagaaaaagt attgaacaaa tgatttattt agtgtacaat aatcatgtaa aaacatagta
     8761 atggagggag acatttcata atgaaaatta aggtaggaat gaacggattt ggaagaatag
     8821 gaagagctgt attaagaata gctcaagaag aattaggaga taatatagaa attgtagcca
     8881 taaatgcaag agcaacaaca gaatctttgg cacatttatt tacatatgat tcatgctatg
     8941 gaacttttag aggtgaagta gaggcaaagg atgaagacac tctagtagta aactctaaag
     9001 agataaaaat attaagatat aatgacccag aagaattacc ttggaaagaa ttgggggttg
     9061 atatagtaat agaatcaaca ggattattta cacaaagaga aaaggcagaa aaacatatta
     9121 aagcaggagc aaaaaaagta attataacag ctccaggaaa aaatgaagat ataactatag
     9181 ttatcggagt taatgagaaa gaatatgata atgaaaagca caatataatt tcaaatgcat
     9241 cttgtactac aaattgtcta gctccttttg ctaaagtatt ggacgaaaaa tttggtatag
     9301 taaaagggtt aatgactaca gtacattcat atactaacga tcaaagaata ttagataaaa
     9361 gccataaaga tttgagaaga gcaagagcag cggctgaatc tataatacct accactacag
     9421 gagcagcaaa agctgtgtca agagtactac cacaattaga aggaaaatta aatggttttt
     9481 cacttagagt accaacacca acagtttcac ttgttgattt agtgtgcgaa cttaaagaaa
     9541 acgttacatc tgagcaagtt aactctgtgt taaaagatgc tgctgaagga gaattaaaag
     9601 gtgttttagg atattgtgac aagccacttg tttctataga ttataaagga gattcaagat
     9661 catctattat agacgctcta tccacaatgg ttatagaaga caatatggtt aaggtagttt
     9721 cttggtatga taatgaatgg ggatattctt caagaactgt tgacttagta aaatatgtag
     9781 ctgaaaaatt aaaataatat atatttctta aagcaaattt taaaaaaatt ttttaaaaaa
     9841 attatataaa actaaaaaaa aagattatga aaaatattga aggaaaaatt ttttcataat
     9901 cttttttctt tcatgcaaaa agatacaagt tacaacttat atttgcatat taggtcgtta
     9961 gagaagtata tatatattta gtaaggaatc atacttttta taaaatgaaa gataagatgt
    10021 cgaaaacttg cataaatctg aaaaattttt attattaaaa tactgatttc cattttaaaa
    10081 atgataaaaa aatgacaaat aaagttgcaa atagtaatac ttataagtat aattaaaaaa
    10141 gagaaaaggt tttgttaaac tttataacaa aaaaagaagg gatgattcaa aatggagaag
    10201 ttaacagaca ggagacaggt taaggcagta agcatggaaa ccttcatttt cctaatatta
    10261 ctagtagttg gttttgggta tgttggtagt attatgggag caggaatgat gttcaaagta
    10321 ataatgagta cagcacatgc tttactattg gagacagttt tcttaattat ggctatggca
    10381 gttcttgcag gcgcattaag cgcactactt tcagagtttg gagtaatagc gttaattaat
    10441 aaaattttcg ctgtatttat gaagccttta tatggactac ctggtgctag tatagcagga
    10501 gctataacaa cttatttatc agataatcca gctattatac cttttgctaa agataaaaca
    10561 ttcacacagt attttaaaca ataccaagtt ccagcattat gtaacttagg aacagccttt
    10621 ggtatgggac ttatcttaac aacatttatg atttctcaag gtacagaata tgtacttcca
    10681 gcattaattg gtaatttagg tgcaattata ggtagtgtca taagtgttag aataatgttg
    10741 acatttacta agaagtttta taaatacaat ccggaagaag ataaagcaac aggaacatta
    10801 gagaaaaagg atgaatttag agaaatcaga gaaggaaatg tatttcaaag agctttagat
    10861 gcaattcttg aaggtggtaa aatgggggta gatatgggaa tggctataat tcctggagtc
    10921 ctagtagtat gtacattggt gatgttatta acttttggac catctacaga tcctgttaca
    10981 ggtcaagaag tttatacagg agctgcatat gaaggaataa aattacttcc agttattgga
    11041 gataaacttg gatttatatt agaaccatta tttggattta catcaccaga ggcaatagca
    11101 ttccctataa cttcattggg agctgttggc gcagcaatgt ctctagttcc agagtttata
    11161 aagtcaggag ctataactcc taatgatata gcagtattta cagctatggg tatgtgttgg
    11221 agtggatatt taagtacaca tattggtatg atggatgcat taaatgctag acagttggca
    11281 ggtaaagcta ttctttctca tacaataggt ggtttatgtg caggagcagc tgctcacttt
    11341 atatttacac tcgtaggata aatgtaatca gctaagataa aaaataatat acaaaaaatg
    11401 gttgttgata tgtaataaga atttacatat caacaaccat ttttttctga ctaaagataa
    11461 tttataatac ataaacatta agtggatatt agagttaagt tatatttatg taaaaagtaa
    11521 caaaaatctg tagaaattta tgacaaaatt tagtacacta actatatgtt cttatttaaa
    11581 atttaaggtt agaattagga attacctagt agagtaagct ttgattaata aaagaatcat
    11641 aaaataaaaa tattagtcat aaagattata aataacttac ttaaaataaa gccatagaac
    11701 ttacaaaaat taaaaaagca tataaatatg gaggggtaca atggatgaat tatttcatat
    11761 aggaattgat gtaggttcta caacggtgaa ggttgtggta cttaataata gtaataatat
    11821 agttcataaa gaatatagaa gacattattc tgatgtaaaa aaatcagtta aagaagtact
    11881 aaatggtata tatgaaaaat tgggagatat aaatactacc attataataa ctggttcagg
    11941 tggaattgga atatcaaaaa aattaggtgt aaaatttgtt caggaagtta tatctagtac
    12001 aaaatcaata gagtattttc atcctgaaac tgatgttgtc atagaacttg ggggtgaaga
    12061 tgcaaagata acatatctaa gtggaggaat agaccaaaga atgaatggaa tatgtgcagg
    12121 tggcactgga gcattcatag accagatggc atcactttta aagacagatg ccagtggatt
    12181 aaatgaactt gctaaagggt ataatgttat atatcccata gcttcaagat gtggtgtttt
    12241 tgctaaaaca gatattcaac ctcttataaa tgatggagcc aatcagactg atatagcaat
    12301 gagtattttc aatgcagttg tcgtacaaac tgtgagtgtc ctttcttgtg gaagaaaaat
    12361 agaaggaaat gttgcgtttt tgggtggtcc attgtacttt ttatctgaac ttagagaagc
    12421 atttaaaaga gtattagatt taaaagatga aaacataatc ttcccagaaa atgcacaact
    12481 ttatattgct attggagcag gattattatc agtagatgaa gataatatac aactaaaatc
    12541 tctaatagaa aaattggata gtataaagaa tattgaagat ggagaagtaa atttattaga
    12601 acctttattt aaagataaaa atgagtatga agaattttca agaagacatg aaaaagaaaa
    12661 aataaattat gtggacataa attcaataaa aagcaattgt tatttaggaa ttgatgcagg
    12721 ctcaactaca actaaagcag cacttattga tgaggatgga agacttgtat attcttatta
    12781 taatagcaat gaaggaaatc cattaaaaac aaccattaaa gttataaatg aagtatatga
    12841 tatattacca aaaaatatta aaatattgag ttcaactgta actggatatg gagaaggtct
    12901 tattaaaaaa gctcttaaaa tcgataatgg agagatagag actatagcac attacaaagc
    12961 tgctaaattt ttcaacaaag atgtagattt tatacttgat attggtggtc aagatatgaa
    13021 gtgcctaaaa ataaaagatg gagtaattga taatataata ttaaatgagg cttgttcatc
    13081 aggttgtggc tcatttttag agacatttgc aagttcttta tctatgacaa tagaagaatt
    13141 tgcgcatgaa ggtatttatt ctcaaaatcc tgtagattta ggttcaagat gtactgtatt
    13201 tatgaattct agagtaaaac aagctcaaaa agaaggtgca agtgttggag atatatcagc
    13261 agggctatct tattcagtaa taaaaaatgc tttatttaaa gtaataaaga ttagagattt
    13321 aaatgagatt ggtaataata ttgttgtaca aggtggaacc ttttataatg atttggtgct
    13381 tagaagcttt gaaaaactaa ttggaaaaaa tgtaattaga cctaatattt caggaattat
    13441 gggagctttt ggttcagcac ttatagctaa agaaaaatat gaaagtggat acaaaacatc
    13501 cttgttatct aaggaagagt tgaataatat caagctagaa gcaagtgtaa ctagatgtaa
    13561 aggttgttca aatcattgtc ttcttacaat aaataaattt tctgataatg aaatttttat
    13621 ttcaggtaat agatgtgaga aaggtgaagc tatttatggt gataaaaaaa taggattaga
    13681 aaagaaaaaa ccaataaatt tatttaagta caaatacaat agaattttta gatacaaacc
    13741 attggaaaaa gaagaagcaa aaaatgggga aatagggata ccaagagtat taaatatgta
    13801 tgaagattat ccattttggt ttactttttt caatgctatg ggctttagag ttgtactttc
    13861 agataggtca tcaaaacagt tatatgaaac tggtataact agtattgcat ctgaaacagt
    13921 ttgttatcca ggaaaattag ttcatggaca tatagaaaat ttaattgcaa aaggtataaa
    13981 aaatatattt tatccaagtg taacaaatga aaataaagag gattcaaatg cagataatta
    14041 ttataattgt cctgttgtaa tatcatattc tgaagtaata aaaaacaatg tagagaatat
    14101 aagaaataag aacataaatt atataaatcc atttataagt ctaaatgaca aggaaaaatt
    14161 gaagaaaaga ctctatgatg aattatcaag acatttttct gatataaaaa taactaaaga
    14221 agaagttaat catgcagttg ataaagctac tgatgaacag aatttattta aaatggagat
    14281 acaagcagca ggtgaaagag cacttaaaga aataaaagaa agaaatatga aggggattgt
    14341 gttatgtgga agaccatatc atatagaccc agaaataaat catggaatgc cagagcttat
    14401 aaattcatta gatatggcag tgcttactga agactctata tgtcatttag ccaatgtaca
    14461 aagaccactt agagttgtag accaatgggt atatcattca agattgtata aagcagctag
    14521 ttttgtaaga gataaaaact atttggaact tgttcaactt aattcatttg gctgtggatt
    14581 agatgcagta actacagacc aggttcaaga aatacttaat gaaaaatcga agatatatac
    14641 tattataaag attgacgaag gcaacaattt aggagcagct aagataagga tgaggtcctt
    14701 aaaagcagct atgtttgaga gagaaagcaa aaatatagat gtaaaaaata taaaggtaaa
    14761 caggatacag tatgctaaaa ataatcagat aacgaacaaa catactatat tagcaccaca
    14821 aatgtctcca atacatttcc aattccttga aaaagctgtt aacttaagtg gttataatat
    14881 agaaattcta aaagatactg atagtagtgt aattgaagaa gggttaagat atgtaaataa
    14941 tgatgcatgt tatccagcta taatagttgt aggtcagcta ataacagcat taaaatctgg
    15001 caaatatgat ttaaataaca cttctgttac tataactcag actggtggag gttgtagagc
    15061 tacaaattat attggattct taagaaaggc tatatacgat gctggattta aagatattcc
    15121 tgtcattgca cttagtgtaa atggaataga agatagtggt ataatggata atatatcact
    15181 aaaattaatc aatagactct ttatgtctgt tgtttatggt gatttgctga tgaaagtact
    15241 atatagagta agaccatatg aaaaagttac tggaagtgca aatgctctat atgaaaaatg
    15301 ggttgatata tgcaaatctt ctcttgttaa agcaaaaatt tctgtattta ctagaaatat
    15361 aaaagatata gtaaaagaat ttgataattt agagatacta gatatcaaaa aaccaaaagt
    15421 aggtttggtt ggagaaatat tggtgaaatt ccatccaatt gcaaataata atttagtaga
    15481 tatattagag cgagaaggtg ctgaagcagt cgtgccagac cttacaaatt tcttcttaag
    15541 ttgtgccttt aatactatat acaaacacac tcatttagaa ggaagtagaa agagtagaat
    15601 gataggagaa gcatttatat acataactgg aatatatcaa agagtatata aaaaagcact
    15661 tgataagagt gagagatttt atgctccagc caatataaaa aatgttgcta aaagtacaga
    15721 accagtagtg tcattaggta atcaaactgg agaaggttgg cttttaacag gtgagatggt
    15781 tgaattatta aatgaaggtg tagaaaacat tatttgtatg caaccttttg gatgtttacc
    15841 taatcacata attggtaagg gttctataaa agaattaaag aggttgtata aaaatgcaaa
    15901 tataatacct attgattatg acccttctgc aagtgaggta aatcaactta acaggataaa
    15961 acttatgctt tctaaggctt ttaaaaatat ataagattta tattttgata tgttaaaagt
    16021 taatgaattt aaaaatatac tctatattaa gtatctataa aaaagagtta tcctattttt
    16081 tagggtaact ctttattagt taaaaaatta tatgtatact gatattaaag gggggaagta
    16141 atatgagttt agtatatgat gtttataaat caaaattagg aaatttgtac atattaagtg
    16201 aagatggttt tatagttagt atatacatag gagatgaaaa atttaataat ttaaaaaatg
    16261 aatgtattaa aaaaggaatt gatataaaga gaagtaagga agatttaaag gaagcaataa
    16321 gccagataga tgattacttt aatggaaaaa gaaaagtctt taatttaaat attcgtattg
    16381 aagggactga atttcaaaaa tcagtttata gggaaatgtt aaaaatacct tatggagaaa
    16441 cattgtgtta ttcagatata gcaagaaata taaacaatcc aaaatcagta agagcaatag
    16501 gacaagcaag taaaagtaat aaaattccaa taataatacc ttgtcataga gtagttggca
    16561 aaaaagatat tggtggatat atggggaatc attctgattt gaaagagata ctattaaatt
    16621 tagaaagaca gagttaactt agaaagaaat gtttttattg ttaatatttg atataataat
    16681 agtaaaaaga agtatttttt acaaaaacaa tgaagaattt attttaattt ataaaaatga
    16741 gggggaattt taatgtgtga taaagttata gcatcaaaat atcatgagaa gggatttaat
    16801 tgtgcagaat cagttataaa agcatataat gaggaattta atacagatat accagtttgt
    16861 ttaggaagtg gactgggttc agggtgtggg gttgctagtt tatgtggtgc agtaaatgca
    16921 tcaaatataa taattggata tgtaaaaggc agaaaccacg aagatgaaag tactaaagct
    16981 aaagtatatg ctaaagattt aactacaaca gtaagaaaag agtatggttc agagttatgt
    17041 atagacctaa aaaaagattt agttgcttgt agagaaataa tggatttcgc atatgatagt
    17101 ctaaaggaaa ctttaaaaaa agaattataa gaaaataagc tatcaagtat aaattatttg
    17161 atagcttatt tttatagtcg atactaaata aatcaaatat attttagaat tattatttgt
    17221 aaataaacag caaataattt taggattttt atttaatata gtttttattt atatttattt
    17281 ttgaatatgt tatactttgt ttaaataaat atttgtaatg agggagatga gaagattgaa
    17341 gaatctcaat ttacttatta ataaattata ttcaaaaaat cataatgaag catataaaac
    17401 ttttttattc ttagaaaatg aaagtttaaa atcaaatatt acatattgtt tttttgactc
    17461 attcctagaa atgattgata acgaaaactc atatattcga acaaggggat tgttattaat
    17521 ctctgcaaat gctcagtggg atattgataa taaaattgaa ataaatatag atagtatact
    17581 aagtcatatc gtagataaaa aaccttctgt atcaagaatg tttattaaat ccatacctaa
    17641 tattacaaag tataaagaaa atcttattaa tcgcataaaa atggaattaa gtaatgcaga
    17701 tataagtatt tataataata atatgaaacc attagtagaa aaggatata
//
LOCUS       DAEPID010000078        17671 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.078, whole genome shotgun sequence.
ACCESSION   DAEPID010000078 DAEPID010000000
VERSION     DAEPID010000078.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 17671)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 17671)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..17671
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.078"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            <1..838
                     /locus_tag="KR257_003015"
     CDS             <1..838
                     /locus_tag="KR257_003015"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436722.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=2
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBH0031686.1"
                     /translation="YIEDRTSVDIIRESDFKKLRQYQNNNYEELTSKESVYYVSDSYK
                     KIFFKDFEIEKINLHIKDANEYDINLFKVQKSILEPEINSQATFDLIVVKDDVFNQLK
                     LHGNSRLIRLIDIKNEKKELDLTLKLKNIVSENMKFTYPFNFTSSIESYDNLIKLSGL
                     MLFIGIFLSVVFLLCTGSIILFKQLSNIYDDKERYIMLIKLGANNKDIEKIISKQLKV
                     IFLMPLVVGTVHNLFAMSIAQKFIPRSLLVPIIITLVIYFIGYFIYYFLTLKYALNMI
                     KE"
     gene            1063..2676
                     /gene="ggt"
                     /locus_tag="KR257_003016"
     CDS             1063..2676
                     /gene="ggt"
                     /locus_tag="KR257_003016"
                     /EC_number="2.3.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728540.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="gamma-glutamyltransferase"
                     /protein_id="HBH0031687.1"
                     /translation="MKFNAYQHKYSSIRNVVYAKNGAVATSTPLASQAGLEILKKGGN
                     AVDAAVATAATLAVVEPTSNGIGGDAYALVWIEEEKRLYGLNSSGFAPENMELKNYNN
                     MKEMPKYGFGAVTVPGIPAAWSELNKKYGKLSLMECLSPAINYAREGYVVSPNVAKVW
                     KKSYELYEKELIGEEFKPWFDTFSKDGKAPEAGDIFICEEQASTLEEIANTQAESFYR
                     GRLADKIDEYSKKFNGAIRKSDLECFYPTWVEPISTEYKGYKIFEIPPNGHGITVLMA
                     LNILKELELEGNIENVEDIHKIIESLKLAFADSKTYVTDIEHMKVKIQELLSQEYAKK
                     RSLLIDNKEALYPTAGEPYCGGTVYLCTADKDGNMVSYIQSNYINFGSGIVIPRTGIA
                     LHSRGNNFNLDPKHHNVVKPFKKPYHTIIPGFLGKEDKAIGPFGVMGAFMQPQGHIQV
                     LTNMIDFGLNPQEALDAPRWQWIKGKEIEVEPEMPKHIIDSLIEKGHEIKVIHDTVDM
                     GRGQIIFKTEQESYICGTESRCDGHIAVY"
     gene            complement(2809..3660)
                     /locus_tag="KR257_003017"
     CDS             complement(2809..3660)
                     /locus_tag="KR257_003017"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902555.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sulfurtransferase"
                     /protein_id="HBH0031688.1"
                     /translation="MKNIISAKELISKLEKNDNLVVIDCRFDLINRTYGIDSYKKGHI
                     KGSFILDIDKDLSSPTKEHGGKNPLQDPLILKEKLEKMGVDNDTTIVTYDDGDLNGAC
                     RLFFQLKHLGLKNVYVLDGGITSFVKEGGELEEKVNIPSCTGKEIRPNINNGLVVPME
                     YVKSKLYKKDTVIIDCRANERYQGLVEPAYSKAGHIPSAKNYFCKDLIKSDFENGSLK
                     DIEFLKKFFKDLNNYDEVILSCGSGISACVNSLALRELDIPHKIYIGSFSDWISYDDN
                     EIKTGQE"
     gene            4286..5179
                     /locus_tag="KR257_003018"
     CDS             4286..5179
                     /locus_tag="KR257_003018"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889384.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sulfide/dihydroorotate dehydrogenase-like
                     FAD/NAD-binding protein"
                     /protein_id="HBH0031689.1"
                     /translation="MSNKIVSKRQLTDSIYLMEIEAPRVAKSSQPGQFIIIKNDEKGE
                     RIPLTIADYDREKGTVTIVFQTVGASTKKLAMFEENDFVMDFVGPLGQASEFIHEDIE
                     ELRNKKILFVAGGVGSAPVYPQVKWFKEHGLDVDVIIGARTKELIILEDDMKKVAKNV
                     YVSTDDGTYGFNGRVTDLLKDLVDNQGKKYDQAIVIGPMIMMKFMCQLTKELNIPTIV
                     SLNTIMIDGTGMCGGCRVSVGNETKFACVDGPEFDGHLVDFDQAMRRQSMYKTQEGRA
                     MLKLEEGDSHHHSNCGCGGNK"
     gene            5179..6573
                     /gene="gltA"
                     /locus_tag="KR257_003019"
     CDS             5179..6573
                     /gene="gltA"
                     /locus_tag="KR257_003019"
                     /EC_number="1.4.1.13"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893107.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NADPH-dependent glutamate synthase"
                     /protein_id="HBH0031690.1"
                     /translation="MDAKKVKVPVREQEPAVRATNFDEVCLGYNKEEAMAEANRCLAC
                     KKPKCVGGCPVGIDIPGFITKIKEDDIEGAAKVIAKSSSLPAVCGRVCPQESQCEGVC
                     ILGIKSDAVSIGKLERFVADWSKENDINLSDTEPKKNQKVAVIGSGPAGLACAGDLAK
                     KGYDVTIFEAMHEPGGVLTYGIPEFRLPKQAVVQPEIDNIRKLGVKIETNVIVGKTIT
                     VDELIEDEGFEAIFIGSGAGLPMFMNIPGENANGVFSANEFLTRVNLMKAYRDDYDTP
                     ISSGKKVAVVGGGNVAMDAARTALRLGSESYIVYRRSEKELPARAEEVHHAKEEGIIF
                     NTLTNPKEILVDENGYVKGMVCIRMELGEPDDSGRRRPIEIEGSEFVLDVDTVIMSLG
                     TSPNPLISSTTKSLDINKKRCLITDENGQTSKEGVFAGGDAVTGAATVISAMGAGKTA
                     AASIDEYLKAKVNA"
     gene            6939..9158
                     /locus_tag="KR257_003020"
     CDS             6939..9158
                     /locus_tag="KR257_003020"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429762.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="EAL domain-containing protein"
                     /protein_id="HBH0031691.1"
                     /translation="MKKREKVFDGLVFKHILILLILLVLIDLTSTIIYASNSMEITSR
                     NMIEASKRELENYLEVNISLLKALSQDDRFSNGETSLIEKGKLLSPYQKEYNLFMIGI
                     TDTKGNASSTYRENVNSIKDKPSFEKAIKTKQVVVSDIEVSNVTGDKVFIIYVPIVKN
                     NEMIGTIFASFYFQDVNNLISRSNFDDSIKFLMIDKDYTIISHPNKKYVNDKSKMLDL
                     EGNIIGTTKSEILKNINKKCQGDFLSWDNWRLYNVKYTNIKWTNWTLVSKCNIFKNFK
                     NLIVNFMIKLYFYIVIFMILWKLSNAKLIEQLKKLAYYDSLSGIKNKEKFRKDSMYIL
                     KNYYQDNFYLVQLDVNKFKYINEMFGYAEGNKILIHISQVLNNNTNKYEICARMDNDH
                     FILLIACNTEDELLNRLSKINKEICNLNTTNSSKYKIVMSSGIYKITKKDDIKKIDLL
                     IDRANIAAKSKKEKYEHSYSFFNEDTRNRLYKEKRLEDNMNKALEKGEFIVYYQPKYS
                     LDDVNEIEGAEALIRWNSPEFGFISPIDFVPLFEKNGFIVNIDMFVFEEVCKTLNKWI
                     NKGYTPVPISVNMSRVHLYRDNFIENITDLISKYNISPEFIELELTESVVFDNLNILI
                     DIMKKIKEIGFLISMDDFGSGYSSLNLLKDLSFDILKLDRGFLIETTDTKRGKIIISK
                     IVEMAKAIDIKVICEGVETYEQVEFLKEIGCDKVQGYLFAKPMVLDEFEKHLNFKFD"
     gene            9305..10051
                     /locus_tag="KR257_003021"
     CDS             9305..10051
                     /locus_tag="KR257_003021"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014466367.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBH0031692.1"
                     /translation="MNILSIRNISKTYCGNIPFKALDKVSLNIEKGEFVSVMGPSGSG
                     KSTLLNIISTVDRQSEGEVVLDGYDVSKLKGEKLAEFRRKQLGFVFQDFNLIDTLTVG
                     ENIMLPLTLEGASIKDMNIQTKSISKFLGIDKILDRKTYEISGGQAQRCAIARAIINK
                     PAILLADEPTGNLDSKSTDDVLKLFTRINKEQKVTTLMVTHEAYSASYSDRVIFIKDG
                     CIYTEIKKSESSNSFYSDILAVLSQIGGVR"
     gene            10051..11931
                     /locus_tag="KR257_003022"
     CDS             10051..11931
                     /locus_tag="KR257_003022"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861246.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBH0031693.1"
                     /translation="MDFRKFAYNNIVRNFRAYLAYFLSSVFSIMIFFVFAVSMFHPII
                     TKSGMQSGSTAFMALMTSELIIFGFSLLFILYSLGNFLKYRLKDFGVLMIIGMSNRQL
                     KKLILIENLIIGFLAVMLGILLGLSISKLFLLYLSKLFYMNLTEFYFPVKAMLLTIVS
                     FMILFLITGPMSLKLLSKKSILELLVGTKKPKKEIKSSKLFGIIGVICLILGYAMILF
                     GNKLKINGGMYTTALLITLGIFLFFSQFTILILKYLKNKEKFYKNKVNMLLISNLIYK
                     LKDNTRLLFLITILLSATLVAFTTTSTLVSSQGEASKNNFPMVYSYFSEHNNEKEYEE
                     LQQIREAIKGYDYKELSFPVLKYNREVLLSVKNYNKLSKELGLDKISSKLEKYEGIII
                     PSSNSQEHINSLKQLKNYSIKNLNIEVKKSKNKIIFPTGLFSKVVVISDDLYNEVKGE
                     FSKINFHGFDYKNWQSSAKITENLKEKHFNLDREYNRSYFLTLPDMYLVELQQSKILQ
                     FMGVFIGVILFIAVFSFLYFRLYTDEIEDNVKYKKLSKIGLSFKNMNKIVSIEIGTLF
                     FIPYFIAIINSIISLLFLNQVLNNSFKLENLGILLLISSIYSLYFYLLKKNYTRKVWF
                     FD"
     gene            12050..13441
                     /locus_tag="KR257_003023"
     CDS             12050..13441
                     /locus_tag="KR257_003023"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420080.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MATE family efflux transporter"
                     /protein_id="HBH0031694.1"
                     /translation="MENQQLLGTERISKLLLKYSIPAIIGMLVNSLYNVVDRIFIGNI
                     PGVGPLAITGLGVTMPIMTIILAFGMLIGIGTTTTISIKLGQGKVEEARKLIGNAMTL
                     SVITGIIIMILGILFANKILTLFGASENTLIYAKSYINIILLGTVVNLLSFSLNHSIR
                     ADGSPKISAGIMIVGCLTNIVLDWILIFGFNLGIQGAAIATVTSQALTAILTIGYYIS
                     GKSNLRFSKSNLKLDKKLIKAVFAIGMSPFAMQLAASLVQVISNIALKTHGGDLAIGA
                     MATISSIAMVFLMPIFGINQGAQPIIGFNYGAEKYDRVKKAYLGSLVVATIILCMGMV
                     VVMLFPEAIIGIFNKDPELMNISVNGLRIYLLMLPIVGLSVTGTNFIQSIGKAKMAML
                     LSLLRQVILLIPAVLILPTFLGLQGVWTAQPVSDFIATVITGIVVFRELKRYTPKTEK
                     LNENERLNEITTE"
     gene            13548..14588
                     /locus_tag="KR257_003024"
     CDS             13548..14588
                     /locus_tag="KR257_003024"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436700.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Fic family protein"
                     /protein_id="HBH0031695.1"
                     /translation="MEFTKKSKLKNMYVNMNVARMLSKINEYKGRQLLYKKQPKEILE
                     NLEKKSLVDCSESTYIGNQRDSSNFNLEKLISNEVTPRSREELSIVEYRDVVKTINSA
                     YESIPISSQTILELHGYLYKFSSTRGGSYKSDNDFIEHNLKPSEFISTDSSVNKVEKA
                     VEEICEAYNTLIEEDEIDILILISAFVLDFILIHPFKEGNIKMARVLILLLLNKNGYE
                     VGRYISLGKIFDDSSYEYYSNLNYLKASIGSEKADMNAWIEYFLETILTAYEKLDDSL
                     NISDKKRQTKTSRIEKIINSTLGYFTKEDIRDLCPDIPEPTINRVFNNLRKQDKIEVV
                     ARGRSAKWKKKY"
     gene            15077..15730
                     /locus_tag="KR257_003025"
     CDS             15077..15730
                     /locus_tag="KR257_003025"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728544.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NAD(P)H-dependent oxidoreductase"
                     /protein_id="HBH0031696.1"
                     /translation="MKKKLLYINVNSKPEDLSSSKTVARKFINKFMEKNKDFEVEEID
                     LYKEHIPRLEYQYFEKRNSIVSEENAKNLDDKDRKELTKIRNLCDQFVNASVYVIAAP
                     MWSLSFPAPLKEYIDCIIQDGKTISFEGNDKPQGILNDIDRSMVYIQSSGGHIPWVLK
                     PVMNKGLNYVESIMKFIGIKKFDELLVDGTGTSEEERQAAIEKASEKIDGIIDGMKF"
     gene            15806..16015
                     /locus_tag="KR257_003026"
     CDS             15806..16015
                     /locus_tag="KR257_003026"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429769.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0031697.1"
                     /translation="MREEKSNEKYDCYWCNQENNFCVEIKDNIVMIDDGTGTLKQAVF
                     IGYKQIQINLNCSHCQNLNRIKLNL"
     gene            complement(16155..16721)
                     /locus_tag="KR257_003027"
     CDS             complement(16155..16721)
                     /locus_tag="KR257_003027"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728545.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1836 domain-containing protein"
                     /protein_id="HBH0031698.1"
                     /translation="MMNNELNTIILETLNNADITSNDIPSIDLYMDQIISLIDNKLSA
                     NKRFESDKILTKTMINNYSKEGLIKPVKGKKYTKEQILQMIIIYSMKNTLTIQEIKRI
                     LHGVYEKDNFSEKDLVSCYEKFMLIKENQRKNIPDFIESNFENISINPENKDDLLIAL
                     LSLTSMADQLKNISEKLVDRYFPDITKK"
     gene            16882..17535
                     /locus_tag="KR257_003028"
     CDS             16882..17535
                     /locus_tag="KR257_003028"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420089.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hemolysin III family protein"
                     /protein_id="HBH0031699.1"
                     /translation="MYQFFLKGRDPISSLTHFIGACLSLLATIILVFQSVTLQETSLL
                     MIVSVSVFGLSLIALYSASSYYHFLKGTPEQELFFRKVDHAMIYVLIAGSYTPICLNF
                     MEKKEGIIFVTAIWIVAFIGIIIKIFWMDAPRWLSTSIYLLMGWAIVFDINAFNSIPK
                     DCLRLLIMEGVSYSIGAIIYIIKKPNISPEFGFHEIFHIFIMIGSLFHFLAVLLYVL"
BASE COUNT         6913 a         1823 c         2962 g         5973 t
ORIGIN      
        1 ttatatagaa gatagaacgt ctgtagatat tattagagaa agtgatttta aaaaattaag
       61 acaatatcag aataacaatt atgaagaatt aacttcaaag gaatctgtgt actatgtttc
      121 tgattcatac aaaaaaatat tttttaaaga ctttgagatt gaaaaaataa acttgcatat
      181 taaagatgca aatgagtatg atataaatct gtttaaagta caaaaaagca tcttggagcc
      241 agaaataaat tcacaagcta cgtttgattt aattgtagta aaagatgacg tatttaatca
      301 gttaaaatta catggaaatt ctagattaat aagattaatt gatataaaaa atgaaaaaaa
      361 agaactggat ttgactttaa aattaaaaaa tatagtaagt gaaaatatga aatttactta
      421 tccttttaat tttacatcaa gtattgaaag ttatgataac ttgataaaat taagtggtct
      481 aatgctgttt ataggcatat ttttgtctgt agtatttctt ttatgtacag gtagtataat
      541 cttatttaaa caattatcaa atatatatga tgataaggaa agatatatta tgttaataaa
      601 acttggagca aataataaag atattgagaa aataatatca aaacagttaa aagttatatt
      661 tttaatgcca ttagttgtag gtacagttca taatttattt gctatgtcta tagcacaaaa
      721 gtttatacca aggtcattac ttgtaccaat tatcataact ctagtcattt attttatagg
      781 atattttata tattattttt taactttaaa atatgctcta aacatgataa aagaataaat
      841 tatttttaag ttaaaagaat tagatatatg ttttgaataa aataacttat ttaagtgcag
      901 atagaaaata ctagaattga gtttaagata tttatttaaa gataaaatta aagttaggaa
      961 aaagtctata ttttatatca ttttgtatca gttacattaa ttgatgttat ataataaatc
     1021 taagcagaat atcaaataaa aaatgacgag gagctgaaat ttatgaagtt taatgcctac
     1081 caacataaat actcatcaat aagaaatgtc gtgtatgcta aaaatggagc agttgcaaca
     1141 tcaacaccat tagcatctca agctggactt gaaatactaa aaaagggtgg aaatgctgtt
     1201 gatgcagcag ttgcaacagc cgccacatta gcagtagtag aacctacaag caatgggatt
     1261 ggaggagatg catatgccct tgtttggata gaggaagaaa aacgattgta tggtttaaat
     1321 tctagtggct ttgctccaga aaatatggaa ttaaaaaatt ataataatat gaaagaaatg
     1381 ccaaaatatg ggtttggagc agtaactgta cctggaatac cagcagcttg gtcagaatta
     1441 aataaaaaat atggtaaact tagcttaatg gaatgcttat ctccagcgat aaactatgca
     1501 agagagggat acgtagtatc tcctaatgta gctaaggtat ggaaaaaatc atatgaactc
     1561 tatgaaaaag aacttattgg agaagagttc aaaccatggt ttgatacatt ttctaaagat
     1621 ggtaaagctc cagaggctgg agatatattt atatgtgaag aacaggcaag tacattagaa
     1681 gagatagcaa atactcaggc tgaaagcttt tatagaggaa gacttgctga taaaatagat
     1741 gaatattcta aaaaatttaa tggggctata agaaagagtg acttagagtg tttttatcca
     1801 acatgggtag aacctataag tacagaatat aagggatata aaatatttga aatcccacca
     1861 aatggtcatg gaataacagt tttaatggca cttaacatat taaaagaatt ggaattagaa
     1921 ggaaatatag aaaatgtaga agacatacat aaaattatag agagtttaaa attagctttt
     1981 gcagattcta aaacatatgt aactgatata gagcatatga aggtaaagat tcaggaatta
     2041 ctaagccaag agtatgctaa aaaaagaagt ttattgattg acaataaaga ggctttgtat
     2101 ccaactgcag gagagccata ttgtggtggt acagtatacc tttgtactgc agataaggat
     2161 ggaaatatgg tttcatatat acagagcaat tacataaatt ttggttcagg aattgtgata
     2221 ccaagaactg ggattgcttt acatagtaga ggaaataatt ttaatttaga ccctaaacac
     2281 cacaatgtag taaaaccatt taaaaaacct tatcatacta taatacctgg atttttaggt
     2341 aaagaagata aagcaatagg tccatttggt gtaatgggag cttttatgca accacaagga
     2401 catattcaag tgttaacaaa tatgattgat tttggattaa atccacaaga ggcgctagat
     2461 gctccaagat ggcagtggat aaaaggaaag gaaatagaag ttgaaccaga gatgccaaag
     2521 cacataatag attcattaat tgaaaagggt catgaaataa aagtaattca tgatactgtc
     2581 gacatgggac gaggtcaaat aatatttaaa acagaacagg aaagttatat ttgtgggacg
     2641 gaatcaagat gtgatggtca tattgcagtt tattaatatt atcaactaaa atatatataa
     2701 taaatttaaa gagtatatga aataattagt aaaggcgaaa gtctacaatg actgacgcct
     2761 ttacaaaatt taagctatca tatgctgatt ttatatagat tatgagcctt attcttgacc
     2821 agttttgatt tcattgtcat cataactaat ccagtcacta aagctaccaa tataaatctt
     2881 gtgaggtata tccagttctc taagagcaag actgttaaca caagcagata tccctgaacc
     2941 acaagataaa attacttcat cataattatt taaatcttta aagaattttt ttaaaaattc
     3001 tatatcttta agtgagccat tttcaaagtc actttttatt aaatccttac aaaaataatt
     3061 ttttgcactt ggtatatgac cagcttttga gtaagcaggt tcaactaaac cctggtatct
     3121 ctcattagca cggcaatcta ttattacagt atcttttttg tataatttag acttaacata
     3181 ttccattgga acaactaaac cattgtttat atttggtcta atttccttac ctgtacaact
     3241 tggtatattc actttctctt ccaattctcc accttccttt acgaaagatg ttattccccc
     3301 atccagtaca tagacatttt taagccccaa atgttttaat tggaaaaata atctgcaagc
     3361 tccatttaaa tctccatcat cataagttac aatcgtagtg tcgttatcaa cacccatttt
     3421 ttctaatttt tcttttagta ttaaagggtc ttgtaaagga tttttaccac catgttcttt
     3481 tgtaggagat gataaatcct tgtctatatc taagataaag ctgcctttga tgtgtccttt
     3541 tttataagaa tcaataccat aagttctatt gataagatca aatctgcaat ctattacaac
     3601 tagattatca tttttttcta gttttgatat aagttctttt gctgaaataa tgtttttcaa
     3661 agaatgtacc tcctgtgttt atattatctt tattttaatt tatattaatt attaacttta
     3721 taaactaata ttattataat ttattacata agtaaataaa tctttagaaa ttgtaaaaat
     3781 tttatataaa aattcaaata attaatgaat attgaaaatt ttagatatat aataaaataa
     3841 gagtatattt tatacaatat gaaagctggt attgcaatag attaaagcct tatacacgtt
     3901 tagtttttaa agaaattagt gttattatga aaacctaagt taatttatta aataaataat
     3961 tgaataaaaa aattttatta tgtatttata aaatttttgt tacaaatttg gcataatata
     4021 gtatacttta agtgtgtatt aggttaaatc tataacaaat tagacgtatg atatagactt
     4081 agtgtttatt ggcatttaca agaaatttgt taatatcaac tatttgtagt ttgggcagtt
     4141 ataattatta taggggggat gtccaataca aaacaatcaa ccaagaacta atattatatt
     4201 ataaagagtt atagttttgt gtgtttatgt ttttaattaa atttaaagtg ggaaaaatat
     4261 atttgttaga atggagaata gcgagatgag taataaaata gttagtaaga gacaattaac
     4321 agatagtatt tatttaatgg aaatagaggc acctagagtt gcaaaatctt ctcaaccagg
     4381 tcaatttata ataattaaaa atgatgaaaa aggagagagg attcctctta caatagctga
     4441 ctatgataga gaaaaaggaa cagtaactat tgtattccaa acagttggtg cttcaactaa
     4501 aaagttagca atgtttgaag aaaacgattt tgtaatggat tttgtagggc cattaggaca
     4561 agcaagtgaa tttatacatg aagatataga agaattaaga aataaaaaga tattatttgt
     4621 agctggtgga gttggttctg ctccagttta tccacaagtt aaatggttta aagagcatgg
     4681 attagatgta gatgtaataa ttggtgcaag aactaaagaa ttaattatat tagaagatga
     4741 tatgaaaaaa gtagctaaaa atgtatatgt atcaacagat gatggtacat atggatttaa
     4801 tggaagagtt acagacctat taaaagattt agttgataat caaggtaaaa aatacgacca
     4861 agcaatagta attggaccaa tgataatgat gaaatttatg tgccaattaa ctaaagaact
     4921 aaatatacct actatagtaa gtttaaatac aataatgata gatggaacag gtatgtgtgg
     4981 tggttgtaga gttagtgttg gaaatgaaac taagtttgca tgtgtagatg gtcctgaatt
     5041 tgatggtcat ttagttgatt ttgatcaagc aatgagaaga cagtctatgt acaagactca
     5101 agagggaaga gctatgctaa aacttgaaga aggcgatagt catcatcata gtaattgtgg
     5161 atgtggaggt aacaaataat ggatgctaaa aaagtaaaag taccagttag agaacaagaa
     5221 cctgctgtga gagcaacaaa ttttgatgaa gtatgcttag ggtataataa agaagaagct
     5281 atggcagaag ctaatagatg tttggcttgt aaaaaaccaa aatgtgtggg tggatgtcca
     5341 gtaggaatcg acataccagg gtttataaca aaaattaaag aagatgatat agaaggtgct
     5401 gctaaagtaa tagctaagag cagttcatta ccagctgttt gtggtagagt atgcccacaa
     5461 gaaagtcaat gtgaaggtgt atgtatactt ggaataaaat cagatgctgt atcaataggt
     5521 aaattagaaa gatttgtagc agattggtca aaagaaaatg acataaattt atctgataca
     5581 gagcctaaga aaaatcaaaa agtagcagta ataggaagtg gtccagcagg tctagcttgt
     5641 gctggtgatt tagctaaaaa aggctatgat gtaacaatct ttgaagcaat gcatgagcca
     5701 ggtggagttt taacttacgg aatacctgag tttagacttc caaaacaagc tgttgttcaa
     5761 cctgaaatag acaatataag aaaattaggt gtaaaaatag aaactaatgt aattgttggt
     5821 aaaacaatta cagtagatga acttatagaa gatgaaggat ttgaagctat attcataggt
     5881 tcaggagctg gtcttccaat gtttatgaat ataccagggg aaaatgcaaa tggagtattt
     5941 tctgcaaatg agtttttaac tagagtaaac ttaatgaagg cttatagaga tgattatgat
     6001 acacctatta gttctggtaa aaaagttgct gtagtaggtg gtggaaatgt tgctatggac
     6061 gctgctagaa ctgcattaag attaggttca gaatcatata tagtttatag aagaagtgaa
     6121 aaagagcttc cagcaagagc tgaagaagtt catcatgcaa aagaagaagg cattatattt
     6181 aatacattaa caaatcctaa ggaaatttta gtagatgaaa atggatatgt taaaggtatg
     6241 gtttgtataa gaatggaatt aggagagcca gatgattctg gaagaagaag acctatagaa
     6301 atagaaggtt ctgaatttgt acttgatgta gacacagtta taatgtcact tggaacaagc
     6361 ccaaatccac taatatcttc tacaacaaag agtcttgata taaataagaa gagatgctta
     6421 ataacagatg aaaatggtca gacttctaaa gagggtgtat ttgcaggtgg agatgctgtt
     6481 actggagcag caacagtaat atctgcaatg ggtgctggta aaacagcagc agcatcaata
     6541 gatgaatatt taaaagcaaa agttaatgct taatttgtaa attaaagaga gggtgtctca
     6601 aaatgaactt tttagttcat gaggcactct ttttgtacaa aatcaaatat gttttaatca
     6661 tttcaacaat gaaaatttca ttcctgtaga aagtctaact tttaggtctt agtacaatct
     6721 ctattttgat gtagccactt ttttagatgg tttaataatt tatcagttat tattgtaata
     6781 tttgatacta agtaacataa ctttgtctaa ctatgataaa atagttatac aataaaggtc
     6841 ttgtaaggag tgaataatgt gtggctaata aaatcagatt tgtcaaatct aacattaaat
     6901 aatagaaaaa taaattgtgt aattaatggt attttaatat gaaaaaaaga gaaaaagtat
     6961 ttgatgggct agtttttaag catatattaa tcttattaat actattagtt ttgattgatt
     7021 taacaagtac catcatatat gcaagtaact ctatggaaat tacttctaga aatatgattg
     7081 aggcatcaaa aagagaactt gaaaactatt tagaagtaaa catatcttta ttaaaagctc
     7141 ttagtcaaga tgatagattt tctaatggtg aaacatcact aattgaaaag ggaaaattat
     7201 taagtccata tcaaaaggaa tataatcttt ttatgattgg tataacagat acaaaaggaa
     7261 atgcttcaag tacatatagg gaaaatgtta actcaataaa agataagcct agttttgaga
     7321 aagcaattaa aacaaagcaa gtagtagttt cagatattga agtcagtaat gtaacaggtg
     7381 acaaagtatt tatcatatat gtaccaattg taaaaaataa tgagatgatt gggaccattt
     7441 ttgcttcttt ttattttcaa gatgtaaata atttaataag tagaagcaat tttgatgatt
     7501 ctattaaatt tctaatgata gataaagatt atactattat ttctcatcca aacaaaaaat
     7561 atgtaaatga taaaagtaag atgcttgatt tagaagggaa tattatagga accactaaaa
     7621 gtgaaatctt aaaaaatata aataaaaaat gtcaaggtga ttttttatct tgggataatt
     7681 ggagattata taatgtaaaa tatacgaaca taaagtggac taattggact ttagtatcaa
     7741 aatgtaatat atttaagaac tttaaaaatc taatagttaa ttttatgata aagttgtatt
     7801 tttatatagt aatatttatg atattgtgga aattaagtaa tgctaaatta atagaacaac
     7861 ttaaaaaatt ggcttattat gattctttaa gtggaataaa aaataaagaa aagtttagaa
     7921 aagattctat gtatatttta aagaattatt atcaagataa tttttactta gtacaattgg
     7981 atgtcaataa atttaaatat ataaatgaga tgtttggata tgctgaaggg aataagatat
     8041 taattcatat atcacaggtt ttaaataata atacaaataa atatgaaatt tgtgctagga
     8101 tggataatga ccattttata ttgttgattg cttgtaacac tgaagatgaa cttttaaata
     8161 gattatctaa aataaataaa gaaatttgta acttaaatac tactaactca tctaagtata
     8221 aaattgttat gtcaagtgga atatataaga ttactaaaaa ggatgatatt aaaaagattg
     8281 acttgttaat tgatagagca aatattgcag caaaaagtaa aaaggaaaaa tatgaacatt
     8341 catattcatt ttttaatgaa gatacaagaa atcgattgta caaggaaaaa cgattggaag
     8401 ataatatgaa taaagcttta gaaaaaggtg aatttatagt atattatcaa cctaagtata
     8461 gtttagatga tgtaaatgaa attgaaggag cagaagcctt gataagatgg aatagtccag
     8521 aatttgggtt tatttcacct atagattttg tacctttatt tgaaaagaat ggttttattg
     8581 taaatattga tatgttcgtg tttgaagaag tatgcaaaac attaaacaag tggataaata
     8641 aagggtatac tcctgtacca atctctgtaa atatgtctag agttcattta tatagggata
     8701 attttataga aaatataact gatttgataa gtaaatacaa tatatctcct gagtttattg
     8761 agcttgaact aacagaaagt gttgtgtttg ataatttaaa tatattgatt gatataatga
     8821 aaaagattaa agagatagga ttccttatat caatggatga ttttggttcg ggatattcat
     8881 ctttaaatct gttaaaagac ctttcttttg atattttaaa attagataga ggatttttaa
     8941 tcgaaacaac agatacaaaa cgtggaaaaa ttattatttc taagattgtg gaaatggcaa
     9001 aagcgattga tattaaagta atctgtgagg gcgtagaaac ttatgaacaa gtagagttct
     9061 tgaaagagat aggttgtgat aaggttcaag gatacttatt tgctaaacct atggtattag
     9121 atgaatttga aaaacactta aactttaaat ttgattaatc attaataatt attagactat
     9181 aagataccct aacaacttac ttacaaatat gtaagttaat tgttagggta tttttatggt
     9241 taaagtagta tattcacgat attatggtat tgtagtaaaa ataaaaaatt atggagaata
     9301 taaaatgaac atattgagta ttagaaatat atcaaaaaca tattgtggaa atattccatt
     9361 taaagcatta gataaggtta gtctaaatat agaaaaggga gaatttgtgt ctgttatggg
     9421 accatctgga agtggtaaat ctactctttt aaatataata tctacagttg atagacagag
     9481 tgaaggtgag gttgtattag atggatatga tgtaagtaaa ttgaaaggag aaaaacttgc
     9541 tgaatttaga aggaaacaac ttggttttgt atttcaggat tttaatttga ttgacacttt
     9601 aactgttggc gaaaatatta tgttgccact tacactagag ggggcaagta tcaaagatat
     9661 gaatatacaa actaaaagta tatctaaatt tttaggaata gataaaattt tagatagaaa
     9721 aacctatgaa atttcaggag gtcaagctca aaggtgtgct attgctagag ctattataaa
     9781 taaacctgcc atacttcttg cagatgagcc aactggaaat cttgattcaa aatctactga
     9841 tgatgttttg aaattattta ctaggataaa caaagaacaa aaggtaacaa cacttatggt
     9901 aactcatgaa gcatatagtg caagttattc agatagagta atttttataa aagatggttg
     9961 tatatataca gaaataaaaa aatctgaaag cagtaattct ttctattctg atatactagc
    10021 tgttttgtct caaataggag gtgtaagata gtggatttta gaaagtttgc ttataataat
    10081 atagttagaa atttcagggc atatttagca tattttttaa gttctgtttt ttctataatg
    10141 atattttttg tttttgcagt gtctatgttc catccaatta taacaaaatc tggaatgcag
    10201 agtggttcta ctgcatttat ggctcttatg acttcagaat taataatatt cggttttagt
    10261 ctacttttta tattgtactc tttaggaaat ttcttaaaat atagattgaa agattttgga
    10321 gtattgatga taattggaat gagtaacaga caactgaaaa aattgatatt aattgaaaat
    10381 ttgataatag gatttttagc agtgatgtta ggaatattac ttggtttatc aatttcaaaa
    10441 ttgtttttat tgtatttaag caaactgttt tatatgaatt taactgaatt ttattttcca
    10501 gtaaaagcaa tgctattgac tattgtatca tttatgattt tatttttgat aacaggacca
    10561 atgagcttaa aattattgag taaaaagagc attttagagc ttttagtagg tacaaaaaag
    10621 cctaaaaaag agataaaatc ttcaaagcta tttggaataa ttggtgtaat atgtcttata
    10681 ttaggatatg ctatgatact atttggcaat aagttaaaaa taaatggagg tatgtataca
    10741 acagcactat taattacttt ggggatattt ttattttttt ctcaatttac tattttgata
    10801 ttaaagtatt taaaaaataa agaaaaattt tataagaaca aagtaaatat gttacttata
    10861 agtaatttga tatataaatt aaaggataat acacgattgt tatttttaat aacaatactt
    10921 ttatcggcta ctttagtagc atttacaaca acttcaacac ttgtaagttc tcaaggagaa
    10981 gcttctaaaa ataatttccc aatggtttac tcatattttt cagagcataa taatgaaaaa
    11041 gaatatgaag aactacaaca aattagagaa gcaatcaaag gatatgatta taaggagtta
    11101 agttttcctg tacttaaata taatagggaa gtcttactaa gtgtaaagaa ttataacaaa
    11161 ttatcaaagg aattgggatt agataaaatt agttcaaagt tagaaaaata tgaagggatt
    11221 ataattccta gtagcaattc gcaagaacat ataaattctt taaaacaatt aaaaaattat
    11281 agtataaaaa atttaaatat agaagtaaaa aaatcaaaaa ataaaataat ttttcctaca
    11341 ggactgttta gtaaagttgt ggttataagt gatgacttat acaatgaagt aaaaggtgaa
    11401 ttttcaaaaa ttaattttca tggatttgat tataaaaact ggcaaagcag tgcaaagata
    11461 actgaaaatt taaaagaaaa acattttaat ttggatagag aatataacag gtcatatttt
    11521 ttaacattac cagatatgta tttagtagag ttacaacaaa gtaaaattct tcaatttatg
    11581 ggtgttttta taggagtgat attatttata gcagttttta gttttttata cttcagatta
    11641 tatacagacg agatagaaga taatgtaaag tacaaaaaac tatcaaaaat aggtctatct
    11701 tttaaaaata tgaataagat tgttagtata gagataggta cattgttttt tataccgtat
    11761 tttatagcaa ttataaatag cataatttct ttactgtttt taaatcaagt attaaataat
    11821 agttttaagt tagaaaattt gggtatatta ctactgatat catctatata ttcactttat
    11881 ttttacttat taaaaaaaaa ttatactaga aaagtttggt tttttgatta aagtggtata
    11941 taatagatat ataaattaat atttaaaaag tagttaatat taggggaggg catttgcacc
    12001 tcccttgtaa tatgtggaaa attgaatatt agaagaagga ggagacttga tggaaaatca
    12061 acaattatta ggaacagaac gaattagtaa attactacta aaatattcta taccagctat
    12121 aataggtatg ttggtaaata gtttatataa tgtagtagat agaattttta ttggaaatat
    12181 accaggggtt ggaccacttg caataacagg tcttggtgta acaatgccaa taatgacaat
    12241 aatacttgca tttgggatgt tgataggtat aggaactact actaccatat caataaaact
    12301 tgggcaaggt aaagtagaag aggcaagaaa acttatagga aatgcaatga cgttatctgt
    12361 aataacagga attatcataa tgatacttgg aatattattt gcaaataaaa tacttacatt
    12421 gtttggagca agtgaaaata ctttaatata tgcaaaatca tatatcaata ttatattatt
    12481 aggtacagta gtaaatcttc tttccttttc tttaaaccac tcaataagag ctgatggtag
    12541 tcctaaaatt tcagcaggaa taatgatagt aggatgttta actaatatag ttttagactg
    12601 gatattaata tttggattca atttgggaat acaaggagct gcaattgcta cagtaacttc
    12661 tcaggctctt acagctattt taactatagg gtattatata agtggaaaat caaacttacg
    12721 attcagtaaa tctaatctaa aattagataa aaagctaata aaagcagtgt ttgcaatagg
    12781 tatgtcgcca tttgctatgc aacttgcagc aagtttagtt caagtaatat caaatattgc
    12841 acttaaaact catggtggag atttagctat aggggctatg gctactattt cttctattgc
    12901 aatggtattt ttgatgccta tctttggaat aaatcaagga gcgcaaccta ttataggttt
    12961 caattatgga gctgaaaaat atgatagggt taaaaaagca tatttaggtt cattagtagt
    13021 agctactata attttatgta tgggtatggt agtagttatg cttttcccag aagctattat
    13081 aggtatattt aataaagacc ctgaacttat gaatatatct gttaatggat taagaatata
    13141 cttacttatg ttgccaattg taggcttatc agttacagga acaaacttta tacaatctat
    13201 aggaaaagca aaaatggcta tgttattgag ccttttaaga caagtaattt tattgatacc
    13261 agcagtatta attcttccta cattcttagg tttacagggt gtatggacag ctcaaccagt
    13321 gtctgatttt atagctacag taattacagg tatagttgta tttagagaat taaaaagata
    13381 tactcctaaa actgaaaaat taaatgaaaa tgaaagacta aacgagataa ctactgagta
    13441 aaaatataaa ttcagataat tgagcaagaa attgcaaaaa atacgattat atgataaaat
    13501 aaaaccgctg tcaaggataa gagaaattct aattatggag tgattttatg gaatttacaa
    13561 agaaaagcaa attaaaaaat atgtatgtaa acatgaatgt agctagaatg ttgtctaaga
    13621 taaatgagta taagggtaga caactgcttt acaaaaaaca accaaaagaa attttagaaa
    13681 acttagaaaa aaaatcttta gtagattgtt ctgaatctac atacattgga aatcaaagag
    13741 atagtagtaa ttttaatcta gaaaagttga taagtaatga agttacacct agaagtagag
    13801 aggaattgag tattgttgaa tacagagatg tggtaaaaac tattaacagt gcttatgaga
    13861 gtattcccat cagttcacaa acaattcttg agcttcatgg atacttatat aaattttcat
    13921 ctactagagg aggaagttat aagtcagata atgattttat tgaacacaat ttaaaaccta
    13981 gcgaatttat aagtactgat tcaagtgtca ataaagttga aaaagctgta gaagaaatat
    14041 gtgaagctta taatacattg atagaggaag atgaaattga tatattaata ttaatttctg
    14101 catttgtgtt agatttcata ttgatacatc cattcaaaga aggtaatata aaaatggcga
    14161 gagtacttat cctattgtta ctaaataaaa atgggtatga agttggaaga tatataagtt
    14221 taggaaagat atttgatgat agttcatatg aatattatag taatttaaat tatttgaaag
    14281 cctcaatagg tagtgaaaaa gcagatatga atgcatggat tgagtatttt ttagagacga
    14341 tattaactgc atatgagaag ctggatgata gtttaaatat atctgataag aaaagacaaa
    14401 caaaaactag tagaatagag aaaataataa attctaccct tggatatttt acaaaagaag
    14461 atataagaga tttatgtcct gacattccag aacctactat aaatagagtt tttaataatc
    14521 taagaaaaca agataagata gaagttgttg caagaggaag aagtgcaaaa tggaagaaaa
    14581 aatattaaaa aatgtttaga taactaaaat ggtatagtgt tttacactat accattttta
    14641 atgtcattag catgagcaat aatttaacaa cttaagcaat atcaatttta tttattgatt
    14701 atttttgaac tgaaaaatgg cgttatatgg tatacctcag tggtaattaa ttttggatga
    14761 gaagatataa tattacagaa tatattagga gtatatgtag aaaaaatata ataaaagtgt
    14821 gaggcttagt aattaacaaa ttatgtggct tcacactttt ttataaaata aagatactta
    14881 gcagaataat attttagttg atatgtttat aagatggtac ttgtttgggt aaaagtataa
    14941 atagtaaaaa agtagaagta atgtgtataa aaacataagt tacattctgt aataatagtt
    15001 attttataat tcaacaaaag aatagaatgg gtatatttgt gaaataataa tataaaataa
    15061 tcttaggagt gagcttatga agaaaaaatt attatatata aatgtaaatt caaaacctga
    15121 agacttatct tcaagtaaaa ctgtagcaag aaaatttata aataaattta tggaaaaaaa
    15181 taaagatttt gaggttgaag agatagacct ttataaagaa catataccaa gacttgagta
    15241 tcagtacttt gaaaaaagaa atagcatagt tagtgaagaa aatgctaaaa atttagacga
    15301 taaggataga aaagagctta caaagattag aaatctttgt gaccaatttg tgaatgcaag
    15361 tgtttatgta atagcagcac ctatgtggag tttatctttt ccagcaccac ttaaagagta
    15421 tatagattgt ataattcaag atggaaaaac tatatctttt gaaggcaatg ataaaccaca
    15481 aggaatttta aatgatattg atagaagtat ggtatatata caatcttctg gtggacacat
    15541 accatgggtg ttgaagccag ttatgaataa agggttaaat tatgtggaaa gtattatgaa
    15601 atttatagga attaaaaaat ttgatgaatt gttagtagat ggaactggaa ctagtgaaga
    15661 agaaagacaa gctgcaatag aaaaagcatc tgaaaaaata gatggtataa tagatgggat
    15721 gaaattttaa ttataatatt ttattaaaaa tataaaggaa aaacctcttt taatgtagaa
    15781 acttatattg aaggaggcga gaatcatgcg agaagaaaaa agtaatgaaa agtatgattg
    15841 ttattggtgt aatcaagaga ataatttctg tgtagaaata aaagataata tagtcatgat
    15901 agatgatggc actggtacgt taaaacaagc cgttttcata gggtataaac aaatccaaat
    15961 taatttaaac tgttcacatt gtcaaaactt aaatagaata aaattaaatt tgtagaattt
    16021 taaaatggaa attattgaag gaattaaaaa tagaaagtgt taatatttag actgaaaatt
    16081 atattttata caataaaagt ttatttaaat aacattgtat tttaatattt attttcagtc
    16141 ttactttatt aaaattattt tttggttatg tctggaaaat atctgtctac taatttttct
    16201 gaaatatttt ttaattggtc agccattgaa gtcagactta ataaggctat caataaatca
    16261 tctttatttt ctggatttat actaatattt tcaaaattag actctataaa gtccggtata
    16321 ttctttcttt gattttcttt tattaacatg aatttttcgt aacatgaaac taaatctttt
    16381 tcactgaaat tatccttttc atacacacca tgtaagattc ttttaatttc ttgtattgta
    16441 agtgtatttt tcatagaata aataattatc atctgtaaaa tttgttcttt agtatacttt
    16501 tttcccttaa ctggtttgat taatccctct ttgctgtaat tatttatcat ggttttagta
    16561 agaattttat cactttcaaa tcttttatta gcagaaagct tattgtcaat tagagaaata
    16621 atttgatcca tatataagtc aatagatgga atatcgtttg aagttatatc tgcattattt
    16681 agtgtttcta gtattatagt attaagttca ttattcatca tatgttacct ccataatata
    16741 tataatacac taaattagaa agtaaaacaa tattaaggct tgtaaaaaaa acataaagtg
    16801 gtataattaa atatataata tagtaatcaa aactatattt atgaatctga tttttaaaat
    16861 acataattgt aggaggacga aatgtatcaa ttttttttaa agggtagaga cccaataagc
    16921 agtttaactc attttatagg tgcttgttta tctcttttag caactataat tttagttttt
    16981 caatctgtta cattacagga aacttctctc ttgatgatag tatctgtatc tgtatttgga
    17041 ctttcactaa ttgctttata tagtgcaagt tcgtattatc attttttaaa ggggacacca
    17101 gaacaagaat tgttttttag aaaagtagac catgcaatga tttacgtatt gattgctggc
    17161 tcttatacac caatatgtct gaattttatg gaaaaaaaag aaggcataat atttgttaca
    17221 gcaatatgga tagttgcatt tattggcata ataataaaaa tattttggat ggatgcacct
    17281 agatggttat ctaccagtat atatttactt atggggtggg caattgtttt tgatataaat
    17341 gcattcaatt caattcctaa ggattgcctt agactattaa ttatggaagg tgtatcttac
    17401 tctataggtg cgattattta tataattaaa aagcctaata taagtcctga gtttggattt
    17461 catgaaatat ttcatatttt tattatgata ggttctttat ttcacttttt agcagtttta
    17521 ttgtatgttt tatagtttta aaagatttga ttaattgata ctaaaattct acaatgaata
    17581 aaatggaact gccttatata gattatatct tagacaataa gacagttcct tattataaat
    17641 attaaattct acttataata aaattttgat a
//
LOCUS       DAEPID010000079        16952 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.079, whole genome shotgun sequence.
ACCESSION   DAEPID010000079 DAEPID010000000
VERSION     DAEPID010000079.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 16952)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 16952)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..16952
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.079"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            <1..1085
                     /locus_tag="KR257_003029"
     CDS             <1..1085
                     /locus_tag="KR257_003029"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889520.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=3
                     /transl_table=11
                     /product="EAL domain-containing protein"
                     /protein_id="HBH0031700.1"
                     /translation="IFEEEMFARISADNFIIIMKYIEEEDITKRLKTIFEELDLFNNN
                     QEEKYKLVLSCGIYFILPEDRDINSIIDRANIPHKMAKGGHKSSYAFYDNKIHDQEIK
                     EKEMENTMFSSLENKEFIIYLQPKIELNTGEIQGSEALVRWKRPDKGLIPPNEFIPFF
                     ERNGFVINLDLYVLEEVCIYLRKWIDAGINPVTVSVNVSRIHLYCNNFIETYKNIIDK
                     YNIPAKYIELELTESIIFDNFDILIDIMNNLKKIGFLISMDDFGSGYSSLNMLKEIPM
                     DILKLDQKFIMETYNSKRSKIIVTKVIEMAKELGMKVISEGVETEEQFKLLKEVKCDM
                     AQGYLFGKPMPIEEFEHLIVSNLVRG"
     gene            1261..1629
                     /locus_tag="KR257_003030"
     CDS             1261..1629
                     /locus_tag="KR257_003030"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436369.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GntR family transcriptional regulator"
                     /protein_id="HBH0031701.1"
                     /translation="MEWELDNNKPIYIQLVEHLKLKIISGEIKIGSKLETVRALAEDA
                     EVNPNTMQKALTELERQGLVYSQRTKGRFVTDDKEKIKAMKEEIANVEINTLKVTLEK
                     LGYDRDEMLKLITENLKGEL"
     gene            1631..2356
                     /locus_tag="KR257_003031"
     CDS             1631..2356
                     /locus_tag="KR257_003031"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436372.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBH0031702.1"
                     /translation="MDKNISNVSQDGIVEFKGVNKSYGTKNVLKNIDLNIPKGKIVGL
                     LGPNGSGKSTMIKLMNGLLQPDNGEIMINGMKPSIDTKKIVSYLPERTYLNDWMKVSD
                     LLKFFYDFYSDFDVRRANEMIKSLDIDVNEKLKTMSKGTKEKVQLILVMSRNASIYIL
                     DEPIGGVDPAARSYILKTILKNYSEDSTLLIATHLISEIENICDEIIFISKGEIVLQG
                     DVEAIREEKGKSIDALFREEFKC"
     gene            2350..3114
                     /locus_tag="KR257_003032"
     CDS             2350..3114
                     /locus_tag="KR257_003032"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430055.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBH0031703.1"
                     /translation="MLGKLLKYELKASGRIFIPLYIAILIVAVFNGIFMNTNILQVQG
                     IGILVLTSLFMALGVLTIVVTIQRFRKNLLGDEGYLMFTLPVSTSSLILSKCITALIY
                     AVLSFIVAVFTFGVLMLFGTSGILLPEILDLFNTSFKWISENFLDILLLVVVMFISYS
                     SFILLLYTSISMGQLPKFNKHRNIVAFASFIAINIVISIVGDAVGSILPNEDTNMVYH
                     LYQSPSFMLAILGSLVVAIALFFATKFILDKKLNLE"
     gene            3336..4586
                     /locus_tag="KR257_003033"
     CDS             3336..4586
                     /locus_tag="KR257_003033"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902660.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MFS transporter"
                     /protein_id="HBH0031704.1"
                     /translation="MKSYTKAKWSVWGIITFSFVLVLFLRMSTAVVSDNLANELGFNS
                     IQISNIASFCLYAYAFMQIPAGILIDKYGARKISSLGIIMASLGSILFGLIQSIELAY
                     ISRVIVGAGTSVILLCILKIQGRWFNKSEFASATAKFSFVGNLGGVLATFPLVFLSEL
                     VGWRNSFLLIGIIGVVIGCFMYIIVRDTPKEYGFNIDTEPYEKSEKVNIVDGIKSVIK
                     NKSTWYNSMIMFSFVGLTSAFISLWGVRYIMDVYGVSKSFSAFIVSFFTYGFIFGSII
                     MDFVFAKIRSSKFNIIKFGAMIDLFIWIVIVVVYQVKPPIIVLPISFFIMGCIVMSHL
                     QVFNDAKYKNKEIYSGLATSVINTFEFIGSGIINLIIAISLQVNSYNIVDGYKKGFVV
                     FIVLSIITIVSSHIGVKNDDFKAI"
     gene            4779..5663
                     /locus_tag="KR257_003034"
     CDS             4779..5663
                     /locus_tag="KR257_003034"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436388.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="mechanosensitive ion channel"
                     /protein_id="HBH0031705.1"
                     /translation="MDTTKIDDISKLDLNNLDINKMDMGGIMESLLEWATTSGVKLII
                     GILILSIGFKIIKKFVNHVMLLLSKRDIDLTLRRFLKSLLLSVLKVAVIIIVLEYWGM
                     SLSSFAAVIASAGVAIGLALQGSLSNFAGGFIILLIRPFKVGDYVEAAGHGGTVEQIG
                     LFYTQLVTPDNKQILIPNGSVSNDSLINYSAKNTRRVDLTFSVGYEDDILHVRRVLKD
                     IVNNHKLIINEPEPFIGVVEHGDNAIKFATRVWCKTEDYWTIYLDLLEEVKVRFDEEG
                     ITIPYPKMDLTVKELNKI"
     gene            6022..6639
                     /locus_tag="KR257_003035"
     CDS             6022..6639
                     /locus_tag="KR257_003035"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902665.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PepSY domain-containing protein"
                     /protein_id="HBH0031706.1"
                     /translation="MCKKMYLLVVGILIAGLLTACNGSPTKDSEQAQDNTKKEANVSN
                     NALKDEKNNENLMEQDFKVPYTDAINIFKDKYKDADIVDLSLERDLNKFVYTVEGVDD
                     NNEYKMKIDANTKDVLEDKTEKLDSEDLNGVARKEKLDFNDIMTPQQAMEIALKEQNG
                     MVKEWSLDKDLDVTFYKIRIDKDKNEYDIKVDSKKGTVLKVEKED"
     gene            6747..9278
                     /locus_tag="KR257_003036"
     CDS             6747..9278
                     /locus_tag="KR257_003036"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420250.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="FAD-dependent oxidoreductase"
                     /protein_id="HBH0031707.1"
                     /translation="MSLKSLKIKENLYWVGSLDPDLRVFDIIMYTPYGTTYNSYVLKG
                     TEKTVLFETVKDKHFDNYIERLNDLNIDFEKIDYIVVSHTEPDHAGSVEKLLDLAKNA
                     KVVASETAIKYLKEIVNKDFEYVAVTDGDTLSIGDKTLEFFSVPMLHWPDTIYTYIKE
                     DKTLVTCDSFGSHYSNDKIVNTLDEDEEKDYLDALRYYYDCIMGPFKPSMVTAIEKIK
                     DLDIDTVCPGHGPVLTENPRKIIDLYYNWSVNEQIKLEKEVTICYVSAHGYTKIMAEA
                     IKAYIEKNSNYKVNLFDVIEHKQEDILAKIAVSQGVLFGTPTILGDALKPIWDILISL
                     NPVLHGGKVASVFGSYGWSGEGIENAMERISQLRMTAVKPFAVNFKPSNEEIDKLHSY
                     TGKFLDKLNSTFGSKKKTKKFKCVICNEVFEGDSAPSVCPVCGAKEDQFIEVEEDEVT
                     FRKDTDEYFVIVGNGAAGFYAADAIRKRNKTCKITMISNEDELTYYRPALSDGINEEL
                     GSDFYMEDKDWYDKNNIVVILGTNVDKLDEVNKTIIVNDGAIKFDKLVIATGSRNFIP
                     PIKGHDLENVFTLRNIKDLYSVKEALEKSKKVVVIGGGLLGLEAAWEFRLKGLEVVVV
                     EAMDSILSKQLDKEGSKILEQCVRDTGIDVRLGVAVDGIEGDGKAQKVVFKDGDSVDC
                     DMVVFSIGVRANTQMVQDTSVKIDRGIVVDKTLQTNVKDIYACGDVAQVGNISLAIWP
                     SSVEMGKIAGANASGDNLTFESEVYPVSLDAMNVKVFSIGNIQNFDKEISSKDEGQRI
                     YKKLFMKDGSLVGAILINDLSCTVKLIRLISEKGDFEDIMKADIL"
     gene            9712..10413
                     /locus_tag="KR257_003037"
     CDS             9712..10413
                     /locus_tag="KR257_003037"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_021418928.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="VanG-Cd-type vancomycin resistance DNA-binding
                     response regulator VanR"
                     /protein_id="HBH0031708.1"
                     /translation="MNENILIVDDEKEIADLIEVYLKNEGFTVYKFYTGKEALECIES
                     KNLDMAILDIMLPDIDGFHICQKIREKYYYPIIMLTAKIEDIDKIMGLTIGADDYITK
                     PFNPLEVVARVKTQLRRYMRYNNSYEQQSIIVNEYDIKGLIINKETHKCSLFGKEVAL
                     TPIEFSILWYLCEHQGKVVPSEELFEAVWGEKYLDNNNTVMAHIGRLREKIHEPSKNP
                     KFIKTVWGVGYTIEK"
     gene            10463..11545
                     /locus_tag="KR257_003038"
     CDS             10463..11545
                     /locus_tag="KR257_003038"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012816161.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sensor histidine kinase"
                     /protein_id="HBH0031709.1"
                     /translation="MRTALMAFIAIIFIWILYSFILYGKFSIWIVSFFENAFRMEYKA
                     ALNLYQQIFRNSMELFMILAMVIVFFIIFRVYLNWFTKYFSEINQGIDSLIKEDVGEV
                     ALSPELLAIEKKINSIKHILEQRKFETQMAEQRKNELIVYLAHDLKTPLTSVIGYLTL
                     LRDESQISEELRKKYLSISLDKAERLEDLINEFFEITRFNLSNISLEYSTVSLTRMLE
                     QLTYEFKPTLMSKNLKYTLNVTPNMMIRCDVNKMQRVFDNLLRNAVYYSFEDTTIEIT
                     AVQEDDYIKLKFINHSNTIPEEKLERIFEQFYRLDTSRNSNSGRAGLGLAIAKEIVEL
                     HNGTITAHSENNIITFKVIIPIVGNL"
     gene            11806..12906
                     /gene="vanG"
                     /locus_tag="KR257_003039"
     CDS             11806..12906
                     /gene="vanG"
                     /locus_tag="KR257_003039"
                     /EC_number="6.3.2.35"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_021418924.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="D-alanine--D-serine ligase VanG"
                     /protein_id="HBH0031710.1"
                     /translation="MNNKKIAVIFGGNSTEYDVSLQSAFAVLENLNTEKYDIIPIGIT
                     REGNWYHYIGDYNNIQNNTWFERDTDIIPVIVSQNRVKNGIIEFLIPDAVSQNHIPNS
                     AIESCENDIKYTKLDFVFPVLHGKNGEDGTVQGLFELAGIQVIGCGTLSSALCMDKDK
                     SHKLVHSEGIKVPKSILLKYSDKFNVAELSKDLTYPLFIKPVRAGSSFGISKIYKKEE
                     LQVAVDLAFEHDNEVIIEENIDGFEVGCAVLGNNDLLVGRVDEIELSKGFFDYTEKYT
                     LKSSKIHMPARIDLDCEKRIQETAKIIYRTLGCSGFARVDMFLTPSGEIIFNEVNTIP
                     GFTSHSRYPNMMKGIGLSFEEILDKIIEVYIK"
     gene            12903..13709
                     /locus_tag="KR257_003040"
     CDS             12903..13709
                     /locus_tag="KR257_003040"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436406.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="M15 family metallopeptidase"
                     /protein_id="HBH0031711.1"
                     /translation="MMNNILLDKNKEDKMTNTILLTKDKVYDGNLILVNAFLPVKTSE
                     DIDLIPVDTRFPSILMKREATNILQNILKSICGINEIVPVSGYRTAEEQQDIYSSSLR
                     DNGKDFTKKFVALPNHSEHQTGLAIDLGLKKEVIDFICPEFPYNGICNEFRKAALHYG
                     FIERYQCKKEEITGISQEPWHFRYVGYPHSEIINKMNLALEEYIEYIKRFSYTNCLKI
                     EDKEKIIEIFYVPIHTKEEVRISIPEQCVYQISGNNKDGFIVTFWRNRKD"
     gene            13727..15865
                     /gene="vanT"
                     /locus_tag="KR257_003041"
     CDS             13727..15865
                     /gene="vanT"
                     /locus_tag="KR257_003041"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_021418922.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="serine racemase VanT catalytic subunit"
                     /protein_id="HBH0031712.1"
                     /translation="MIRNKSYAGLDYFRIIAALLIIAIHTSPLLSYSKMADFVLTSII
                     ARIAVPFFFMLSGFFLISTYNYNCNKLKSFLKNVLFIYGIAIVIYIPLNIYTGYFSMN
                     NLVPNIIKDIVFDGTLYHLWYLPASIIGASIAYFLVKKLGLKYSLVITIVIYVIGMFG
                     DSYYGFLEKIPLLKNLYGYIFEVSDYTRNGIFFAPVFFILGGIISNKSNYMSTKNSLI
                     GFLISFLLMLCEGMFLHKLGVQRHDSMYIMLLPCMYFLFTALTFLKGSRARLLRTSSL
                     IIYIIHPMMIVVIRMFSKIFGIQTVLVDNSLIHYIVVSIASFIASIIIILILKPLKKD
                     LKGEHKVNTNRAWIEIDLNNLEHNVKMIQKAMPEDCELMAVVKANAYGHSAFEVATCA
                     NQIGVKAFAVATIDEGIDLRRYGILGEILILGYTNPIRAKELHKYNLTQSVIDLNHAI
                     SLNKQKYNIKSHIKIDTGMHRLGFDVNDVRSILKAFKLKYLDICGIFTHLCVSDSLKD
                     EDVDFTNKQIECFYKLIDFLLKKGIKIPKVHIQSSYGFFNYPNLKCNYVRIGIALYGI
                     LSFPNDTTKLQLDLRPVLSLKSQVILIRKIQKDDSFGYGRVFIASRDSVIAILSIGYA
                     DGIPRNLSCGKSYVIINGCRAAIVGRICMDQLAVDITDIPNVEVGNTAIIIGRDNLSE
                     LSVSEVANNSCSISNELLSRVGRRLNVIKK"
     gene            16179..16799
                     /locus_tag="KR257_003042"
     CDS             16179..16799
                     /locus_tag="KR257_003042"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436409.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TVP38/TMEM64 family protein"
                     /protein_id="HBH0031713.1"
                     /translation="MQYIQELLDLTQNYWVLATIIGLLSAFIESFIPALPLVAIVTAN
                     AAIQGLFIGCLLSWIGSGLGTTSLFLLISRFNDSKLFNKLRNSKTEKAISWMDKQGFK
                     LLFIAYACPFMPGCLVTIASAFGKKDLKDFVPAMLAGKFVMFIVISYVASDIEGFITS
                     PLKIASFILLVFLSWKIGNRVNKNLENHNYDFHHKKHHNDKDDKMI"
BASE COUNT         6426 a         1702 c         3016 g         5808 t
ORIGIN      
        1 atatatttga agaggaaatg tttgcaagaa tatctgcgga taattttatt ataattatga
       61 aatatataga agaagaagat ataacaaaga ggttaaaaac tatatttgaa gaattagact
      121 tgtttaataa taatcaagaa gaaaaatata agttagtttt aagttgtgga atctatttta
      181 tacttccaga agatagagat atcaactcaa tcatagatag ggctaatata cctcataaaa
      241 tggcaaaggg aggacataaa agttcatatg cattttatga taataagatt catgaccaag
      301 agataaaaga aaaagagatg gaaaatacaa tgttttcaag tctagaaaat aaagaattta
      361 ttatatactt acaacctaag atagaactta atacaggaga gatacaaggt tcagaagcac
      421 ttgttaggtg gaaacgtcct gataaagggc taatacctcc aaatgaattt atcccatttt
      481 ttgaaagaaa cggttttgtt ataaatttag atttatatgt gcttgaagaa gtatgtatat
      541 accttagaaa atggattgat gcaggaataa atccagttac tgtttcagtt aatgtttcaa
      601 ggatacattt atattgcaat aattttatag aaacatacaa aaatataatt gataaataca
      661 atatacctgc aaagtatata gaacttgaat taacggagag tatcatattt gataattttg
      721 atattttaat tgatataatg aataatttaa aaaaaatagg atttttaata tctatggatg
      781 attttggctc agggtactca tcattaaata tgttaaaaga aattcctatg gatatcttaa
      841 aacttgacca aaaatttatt atggaaactt ataatagtaa aagaagcaaa ataattgtta
      901 ctaaagtaat agaaatggca aaagagttgg gtatgaaagt catatcagaa ggagttgaga
      961 cagaagaaca gtttaaactt ttaaaagaag taaagtgtga tatggcacaa ggatatttgt
     1021 ttggaaagcc aatgccaatt gaagaatttg aacatttaat tgtatctaac ttggtaagag
     1081 ggtaattaat ctgtaatata aagaatttaa taaattgtgt taaaaatgga ctctaatgta
     1141 gtgttcattt tttttgtaaa attttttata cttttactaa aaagtaattg acatatactt
     1201 tgtattatta tattattgta ttaacaactt aatacaataa tataataagg aggcatgaac
     1261 atggaatggg aacttgataa taacaaacct atatatatac aattagtaga acatttaaag
     1321 ttaaaaataa tttcagggga aattaaaata ggatctaaat tagaaacagt gagagcacta
     1381 gcagaagatg cggaagttaa tccaaataca atgcaaaagg ctctaacaga acttgaaaga
     1441 caaggtttag tttatagtca gagaactaaa ggaagatttg taacagatga taaggaaaaa
     1501 ataaaagcta tgaaagagga aatagctaat gtggagataa atacattaaa agtaacctta
     1561 gaaaagcttg gatatgatag agatgaaatg ctaaaactta ttacagaaaa tctgaaagga
     1621 gaattataaa atggataaaa atataagcaa tgtttctcaa gatggaatag ttgaatttaa
     1681 aggtgtaaac aagagttatg gaactaagaa tgttttaaaa aatattgatt taaatatacc
     1741 aaagggaaaa atagtcgggc tgttaggacc taatggaagt ggcaaaagta caatgattaa
     1801 gctaatgaat ggattattac agcctgataa tggtgaaatt atgataaatg gaatgaaacc
     1861 atccatagat actaaaaaaa tagtttcata tttaccagaa agaacttatt taaatgattg
     1921 gatgaaggta tcagatttac ttaagttttt ctatgatttt tatagtgatt ttgatgttag
     1981 aagagcaaat gagatgatta aaagcttaga tattgatgta aatgaaaagc taaagacaat
     2041 gtctaaagga actaaagaaa aagttcaact tattttagta atgtcaagaa atgcgagcat
     2101 atatatattg gatgaaccta taggtggtgt tgacccagct gcaaggtcat atatacttaa
     2161 gactatatta aaaaattatt ctgaagatag tactttactg attgctaccc atttaataag
     2221 tgaaatagaa aacatatgtg atgagataat attcatatca aaaggagaaa tagtgttaca
     2281 aggagacgtt gaagcaataa gagaagaaaa aggaaaatct atagatgcat tatttaggga
     2341 ggaatttaaa tgttaggtaa attattaaaa tatgagttaa aagcaagtgg aagaatattt
     2401 ataccgttat atatagccat attgatagta gctgtattta acggaatatt tatgaataca
     2461 aatatacttc aggtacaggg aataggaata ctagtattaa caagtctttt tatggcatta
     2521 ggagttttaa ctattgtagt tacaattcaa aggtttagaa aaaatctttt gggggatgaa
     2581 ggttatttaa tgtttactct tcctgttagc actagttcac ttatattatc taaatgtata
     2641 acagcactta tatacgctgt acttagtttt atagttgcag tattcacttt tggagttctt
     2701 atgctttttg gtacttctgg aattttacta cctgaaattt tagatttgtt taacactagt
     2761 tttaaatgga tttctgaaaa ctttttagat attttattat tagtagtagt aatgtttatt
     2821 tcatattcat catttatttt gttattatat acatcaatct caatgggaca attaccaaaa
     2881 ttcaataaac atagaaacat agtggcattt gcttctttta tagctataaa tatagtaata
     2941 tcaattgttg gagatgcagt tggaagcatc ttaccaaatg aagatacaaa tatggtatat
     3001 catctttatc agagtcctag ttttatgctt gcaatacttg gtagtcttgt agttgcaata
     3061 gcgttatttt tcgctacaaa atttatatta gataaaaaat taaatttaga ataaatgttt
     3121 ttatatggag ccatcttttg agtaatgtta aaagatggct cttattattt atgtagttaa
     3181 ttcatgtata taatatgaat agtgttttat ttctagttaa atatatacat atgttgtata
     3241 atgatattgc gtgtaaaaat ttgtaagaat aactatacac tttatataag ttatatcaag
     3301 aaaatttaaa aatatatgga tttgagggag aagatatgaa aagttataca aaggctaagt
     3361 ggagtgtttg gggtataatt acattttcat ttgttttagt attattttta aggatgtcaa
     3421 ctgctgttgt ttcagacaat ttagcaaatg agttaggttt taattctata caaatttcaa
     3481 atatagcatc cttttgccta tatgcatatg catttatgca aatacctgca ggaattttga
     3541 ttgataaata tggagcaaga aaaattagca gtcttggaat aataatggca agtttagggt
     3601 caattttatt tggtttgatt caaagtatag aattagcata tatttctcgt gtaattgtag
     3661 gggcaggaac atcagtaata ttactttgta ttttaaaaat tcaagggaga tggtttaata
     3721 agtcagaatt tgcttctgca acagctaaat tttcatttgt aggaaattta ggtggagttc
     3781 ttgctacttt tccacttgtg tttttgtctg aacttgttgg ttggagaaat tcatttttat
     3841 taatcggtat aattggtgtt gtaattggat gttttatgta tattattgtt agagatacac
     3901 caaaagagta tggattcaat atagatactg aaccctatga aaagtcagag aaggttaata
     3961 ttgttgatgg tattaagtct gttataaaga acaaatcaac atggtataat tcaatgataa
     4021 tgttctcttt tgtgggtctt acaagtgcat ttataagctt gtggggagta agatacataa
     4081 tggacgttta tggtgtgagt aagagttttt ctgcgtttat agtatcattt tttacatatg
     4141 gatttatatt tggttcaata attatggatt ttgtatttgc taaaataagg tctagcaaat
     4201 ttaatataat aaaatttggg gcaatgatag atttgtttat atggattgta attgtagttg
     4261 tataccaggt aaaaccacca attatagttt taccaatatc attctttatt atgggatgta
     4321 tagttatgtc acatctacag gtttttaatg atgccaagta taaaaataaa gaaatttatt
     4381 ctggactggc aactagtgtt attaatactt ttgaatttat aggaagtgga attattaatt
     4441 tgattatagc tatctcttta caagtaaatt catataatat agttgatgga tataaaaaag
     4501 gttttgtagt atttatagta ctaagtatta taactatagt atcatctcat ataggggtaa
     4561 aaaatgatga ttttaaggct atatagtgtt ttattaatag tttaatttag tattatattt
     4621 tgcatatata tataacaaat agtttgcatt ttcctaagat gtataattgg aatataaatc
     4681 ttgtttacta tgtacaaatg gtattgtatt atattaaata gaaaataaga actttaaact
     4741 ataatattgg ttctaaaata taaggtaagg agttttttat ggatacgacg aaaatagatg
     4801 atataagcaa gttagattta aataatttag atattaataa gatggatatg ggaggtataa
     4861 tggaaagtct attagaatgg gctactacaa gcggagtaaa acttataata ggcatactta
     4921 tactttctat tggatttaaa ataataaaaa aatttgtaaa ccatgttatg ttattactta
     4981 gtaaaagaga tattgattta actttaagaa ggtttttgaa gtctcttctt ttgagtgtac
     5041 ttaaagttgc cgttataatc attgttctgg aatattgggg aatgagtttg tccagttttg
     5101 ctgctgtgat agcatcagca ggggtagcaa taggtttggc tttacaaggt agtctatcaa
     5161 attttgctgg aggatttatt atactattga ttagaccttt taaagtagga gattacgtag
     5221 aagcagcagg ccatggagga acggttgaac aaataggact tttttataca caattggtta
     5281 ctccagataa taaacagata cttataccta atggttctgt atcaaatgat agtctaataa
     5341 actattcagc aaagaatact agacgagttg atttgacttt tagtgtaggg tatgaagatg
     5401 atatactaca tgttagaaga gtacttaaag atattgttaa taatcataaa ttaataataa
     5461 atgaaccaga accatttata ggagtagtag aacatggaga taatgctatt aaatttgcaa
     5521 ctagagtttg gtgcaagaca gaagattatt ggacaattta tcttgattta ctagaagagg
     5581 ttaaagttag gtttgacgaa gaaggaatta cgattccata tcctaaaatg gatttaacgg
     5641 taaaagaatt aaataaaatt taattttttt atgtagtgtt taaatttaag aatattatat
     5701 agatatattt ataagatttg tgaaaaatta ataagtcctg ttattttgta agtgaaaata
     5761 taaaaaatgg gagtgtctca aaatgaactt tttagttcat gaggcactct ttttgtatga
     5821 aatcaaatat atttttatta tttcaacaat aaaaaagagg tctgtttcta ttttgagaca
     5881 atattatttt tatgtagatt taatcttaat gagtataaag ttttaaaact actaaaatag
     5941 gaggaatttt aatataaaag ggtaaataaa gggtttagag ggcataatat agaataaatt
     6001 aattatttaa ggagggtttt tatgtgcaaa aaaatgtatt tattagtggt aggtatactt
     6061 atagcaggtt tattaactgc atgtaatggg agtccaacta aggattcaga acaagcacaa
     6121 gataatacaa aaaaggaggc aaatgtatca aataacgctt taaaagatga aaaaaataat
     6181 gaaaatttaa tggaacaaga ttttaaagtg ccatacacag atgcaataaa catatttaaa
     6241 gacaaataca aagatgctga tatagtagat ttaagtcttg agagagattt aaataaattt
     6301 gtttatactg tggaaggtgt agatgataat aatgaatata agatgaaaat tgatgctaat
     6361 acaaaagatg tattagaaga taaaacagaa aagttggatt cagaagattt aaatggagtc
     6421 gctagaaaag aaaaattaga ttttaatgac ataatgacac ctcaacaagc tatggaaatt
     6481 gcattaaaag aacaaaatgg aatggttaaa gagtggagtt tagataaaga tttagatgtt
     6541 actttttata aaataagaat agataaagat aaaaatgaat atgacataaa agtagattct
     6601 aaaaagggaa ctgtattgaa ggtagaaaaa gaagattaga agatttaaac tatctttaaa
     6661 ataatttctt ttttgaataa aatttgttta aaatataaca agtagggtat aaagagacta
     6721 aataactatt ttaggaggag tacggtatgt cattgaaatc gctaaaaata aaagaaaatt
     6781 tatattgggt aggttcgctt gaccctgatt taagagtatt tgacataatt atgtatacac
     6841 cttatggaac tacttataat tcatatgtat taaaaggaac agaaaaaaca gttttatttg
     6901 agacagttaa agataagcat tttgacaatt atattgaaag attaaatgat ttaaatatag
     6961 attttgaaaa aatagactat attgttgtaa gtcatactga accagaccat gcaggaagcg
     7021 ttgaaaagct tttggattta gctaaaaatg caaaagtagt agcttcagaa acagcaatta
     7081 aatatcttaa ggaaatcgta aacaaagact ttgaatatgt tgcagttaca gatggagata
     7141 cattatcaat tggggacaaa actttagaat ttttctctgt acctatgctt cattggccag
     7201 ataccatata cacatatata aaagaggata aaactcttgt aacatgtgat tcatttggta
     7261 gtcactatag taatgataag atagtaaata cacttgatga agatgaagaa aaggattact
     7321 tggatgcttt gagatactat tatgattgta taatgggacc atttaaacca tctatggtaa
     7381 ctgccataga aaagataaaa gatttagata tagatactgt atgtccaggt catggtccag
     7441 tattaactga aaatcctaga aaaattatag acctttatta caactggagt gtaaatgaac
     7501 aaataaagtt agaaaaagaa gttacaattt gttatgtttc tgcacatgga tatacaaaga
     7561 ttatggcaga agctataaaa gcatatattg aaaaaaatag caactataaa gtaaatttat
     7621 ttgatgtaat agagcataag caagaagata ttttggcaaa aatagcagta tcacaaggtg
     7681 tattatttgg aacaccaaca atattaggag atgcgttaaa gcctatatgg gatatattaa
     7741 tatcgttaaa cccagttctt catggtggaa aagttgcttc agtatttggt tcatatggat
     7801 ggagtggaga aggtatagaa aatgctatgg agagaataag tcagcttaga atgacagcag
     7861 taaaaccttt tgctgttaac tttaaaccat caaatgaaga gattgataaa ttacattctt
     7921 atacaggtaa attcctagat aagttaaatt ctacttttgg aagtaaaaag aaaactaaga
     7981 aatttaaatg tgtaatttgt aatgaagttt ttgaaggtga tagtgctcct agtgtatgcc
     8041 ctgtatgtgg agctaaggaa gaccaattta tagaagttga agaagatgaa gttactttta
     8101 gaaaagatac tgatgaatat ttcgtaatag taggaaatgg agcagctggt ttttatgcag
     8161 cagatgctat aagaaaaaga aataaaactt gtaagataac tatgatttct aatgaagatg
     8221 agttgactta ctatagacct gcactttctg atggtataaa tgaagaactt ggttcagatt
     8281 tctacatgga agataaagat tggtatgata aaaataatat agtagtaata ttaggaacga
     8341 atgtagataa attagatgaa gtgaataaaa ctattatagt gaatgatgga gctattaaat
     8401 ttgataagct tgtaatagct acaggaagta gaaactttat accaccaatt aagggtcatg
     8461 atttagaaaa tgtgtttact cttagaaata taaaagattt atatagtgta aaagaagcac
     8521 tagaaaaatc taagaaagtt gtagtgattg gtggcggttt attgggactt gaagctgcat
     8581 gggaatttag actaaaagga ttagaagtag tagtagttga agccatggat agcatactat
     8641 caaaacaact tgataaagaa ggcagtaaaa tattagaaca atgtgtaaga gatacaggaa
     8701 tagatgtaag attgggtgta gcagttgatg gtattgaagg tgatggaaaa gctcaaaaag
     8761 ttgtatttaa agatggagat agtgttgact gtgatatggt agtattttca attggtgtaa
     8821 gagcaaacac tcaaatggtt caggatacat ctgtaaaaat tgacagaggt attgttgtag
     8881 ataagacatt acagacaaat gttaaagata tatatgcttg tggagatgtt gcacaagtgg
     8941 gaaatattag tttagcaata tggccatctt cagtagaaat gggaaaaata gcaggggcaa
     9001 atgcaagtgg agataatttg acatttgaaa gtgaagtata tccagtttca ttagatgcaa
     9061 tgaatgtaaa agtatttagt attggtaata tacaaaattt tgataaagaa atttcatcaa
     9121 aagatgaagg tcaaagaata tataaaaaat tatttatgaa agatggttca ttagttggag
     9181 ctatacttat aaatgattta agctgtactg ttaaattgat aagattaata tctgaaaaag
     9241 gtgattttga ggatattatg aaggctgata tactataatt taaatacatt aaaataaaaa
     9301 ggagttgtct taaaattgat ttttttctaa tcaaatttta aattcaactc cttttttgaa
     9361 tttttatata aaataacatg gaaattttag taatgtctgt ggttacatac ataggtttaa
     9421 ttgtttttta tatggattgt ctctggtata ataaattgaa ttgtgtttga ctgatagata
     9481 tttttattga aagttaatac ctgttatgcg ataataagga cgtgttaggg gagtttttat
     9541 aataacaatt aatctcagtt tttgtgttcc aatagtagca tcaacacatt ctgatgtagt
     9601 agttcttttc ttataaaaat tagttacaaa tatgcttgta attatttgat atgtaaattt
     9661 accaatatta taaatgatga cctcgataat aaggagagtg aaaaataatc tatgaacgaa
     9721 aatattttga ttgtggatga tgaaaaagaa atagcagatt taattgaagt atatttaaaa
     9781 aatgaaggtt ttacagtata caagttttat acaggtaagg aagctctaga atgtattgaa
     9841 tctaaaaatt tggatatggc tattttagat attatgcttc ctgatattga tggatttcat
     9901 atttgccaga aaattcgaga aaaatactat tatcctatca ttatgttaac agctaaaatt
     9961 gaagatatag acaagataat gggtttaacc ataggtgctg atgattatat aacaaagcca
    10021 tttaaccctt tggaagttgt tgcaagagta aagacacaat taagaagata tatgcgatat
    10081 aataattctt atgaacaaca gtcgataatt gttaatgagt atgatattaa aggattgatt
    10141 atcaataaag aaacacataa atgtagttta tttgggaaag aagtagcatt aacaccgatt
    10201 gaattttcta ttctttggta tttatgtgaa catcaaggaa aagtggttcc ttctgaagaa
    10261 ttgtttgaag ctgtatgggg agaaaaatat cttgataata ataacacagt tatggctcat
    10321 atagggcgat tacgtgaaaa aattcatgaa ccttctaaaa acccgaaatt tataaaaact
    10381 gtatggggag taggttatac aattgaaaag taaaaatatt aaagtcaatc ctgactttac
    10441 tcaagtgaga aataaaattt ttatgagaac agctttaatg gcatttatag ccattatttt
    10501 catatggatt ttatattctt ttatattgta tggtaagttt tctatctgga tagtatcatt
    10561 ctttgaaaat gcttttcgta tggaatataa agctgcattg aatttatatc agcagatttt
    10621 ccgtaatagt atggagctct tcatgatact agctatggtg attgtgtttt ttataatatt
    10681 ccgtgtttat ttaaattggt ttacaaaata ttttagtgaa ataaatcaag gtattgactc
    10741 tcttatcaaa gaagatgttg gagaagtggc tttatctcca gagttattgg caatagaaaa
    10801 gaaaataaac tcaattaaac atatacttga acaacgtaaa tttgagacac aaatggcaga
    10861 acaacgtaag aatgaactta ttgtttatct tgcacatgat ttaaaaacac cacttacatc
    10921 agttataggg tatctgacac tacttcgaga tgaaagtcag atttctgaag aactgcgaaa
    10981 aaaatattta tctatttcgt tggataaggc agagcgtctt gaagatttaa ttaatgaatt
    11041 ctttgaaatt acaaggttta atttatcaaa tatatcactt gaatacagta cagtaagctt
    11101 aactcgtatg cttgaacaac taacatatga gtttaaacct actttgatga gtaagaattt
    11161 aaaatataca ctgaatgtta caccaaatat gatgataagg tgtgatgtta ataaaatgca
    11221 acgtgtattt gataacttat tacgaaatgc tgtttattat agttttgaag atactactat
    11281 tgaaataaca gctgtacagg aggatgatta tataaagctt aaatttataa atcatagcaa
    11341 tacgattcca gaggaaaaac ttgagcgtat ttttgaacaa ttttacaggt tggatacatc
    11401 tcgtaattca aacagtggta gagctgggtt gggacttgct atagctaaag aaatagtgga
    11461 gcttcataac gggacaataa cagctcatag cgagaacaat ataattacct ttaaggttat
    11521 tattccgatt gtaggaaatt tgtaagaatt taagtataaa aaaataggaa attctttagg
    11581 ataaataaat aaagagcact cttgttattg atataattac tgtatcaaaa caagagtgct
    11641 tttattttga tacagtaatt atatcaatag aaaaatgtga aaatatatta tgtggaacag
    11701 atgcaattgt aagtgaaggt tgattggatt tgaaatagaa aaagtatttt aacatgtttc
    11761 tgtagattgt ataaaaataa ataaatcaac aaaggagaat caaagatgaa taataaaaaa
    11821 attgcagtta tatttggtgg aaactcaaca gaatatgatg tatcattaca atcagctttt
    11881 gcagtacttg agaatttgaa tacggaaaaa tatgatatta taccaattgg aattacaagg
    11941 gagggtaatt ggtatcatta tattggagat tataataata tccagaataa cacttggttt
    12001 gaaagggata ctgatataat tccagttatt gtttcgcaga accgtgtcaa aaatggtatt
    12061 attgaatttt taattcctga tgctgtttct cagaatcata ttccaaatag tgctattgaa
    12121 tcatgtgaaa atgatattaa atacactaaa cttgattttg tgtttcctgt actgcatgga
    12181 aaaaatggag aagatggaac agtgcagggg ttatttgaat tggcaggtat acaggttatt
    12241 ggatgtggta ctctttcttc agcattatgt atggacaaag acaaatcaca taaacttgtt
    12301 cattcagaag gtattaaagt accaaaatca atattactaa aatactcaga taaatttaat
    12361 gtggctgaac tgtcaaaaga cttaacttat ccattattta taaaacctgt gcgtgcaggt
    12421 tcatcatttg gtattagtaa aatttataaa aaagaagagt tacaagtagc agtagacttg
    12481 gcttttgaac atgataatga agtaataatt gaggaaaata ttgatggttt tgaggtaggg
    12541 tgtgcagttt taggaaacaa tgacttactt gttggaagag tagatgaaat agaattgtca
    12601 aaaggatttt ttgattatac agaaaaatat acattgaaaa gttcaaaaat tcatatgcca
    12661 gctagaattg atttggattg tgagaaaaga atacaagaga cagcaaaaat tatttataga
    12721 actcttggat gttctggatt tgctagagta gatatgtttt taactccatc tggtgaaatt
    12781 atttttaatg aagtcaatac aattcctggc tttacttctc atagtcgtta tccaaatatg
    12841 atgaaaggta ttggactgtc ttttgaagaa atattggaca agataattga ggtgtacata
    12901 aaatgatgaa taatatttta ttagataaaa ataaagaaga taaaatgaca aatactatct
    12961 tattgactaa agataaagtt tatgatggga atctaattct agtaaatgct tttttaccag
    13021 ttaaaacatc tgaagatata gatttaattc ctgtagatac aaggtttcca agtattctta
    13081 tgaaacgtga agctacaaac attttacaaa atattttaaa aagtatatgt ggaataaatg
    13141 aaatagtacc tgtaagtgga tatcgtactg cagaggaaca acaagatata tattcaagtt
    13201 ctctgcgtga caatggaaaa gactttacta aaaagtttgt agcacttcca aatcacagtg
    13261 aacatcagac agggcttgct attgatttag ggttaaagaa agaagttata gattttatct
    13321 gccctgaatt tccttataat ggtatttgta atgagtttcg taaggcagca ctacattatg
    13381 gttttataga gcgttatcag tgtaaaaaag aagaaataac aggaatatct caagaaccat
    13441 ggcattttcg ttatgtggga tatccgcatt ctgagattat caataaaatg aatctcgctc
    13501 ttgaagaata tatagaatat attaagagat tttcgtatac aaattgttta aaaatagaag
    13561 ataaagaaaa aattatagaa atcttttatg tgcctattca tactaaagaa gaagtgagaa
    13621 tctctatacc tgaacaatgt gtatatcaaa tatcgggtaa caataaggat ggttttattg
    13681 tgacattttg gagaaataga aaggactaag aaatggagga acaagaatga ttaggaataa
    13741 atcttatgca gggcttgatt attttaggat tatagctgca ttacttataa ttgcaattca
    13801 tacatctcca ttattatcat atagtaaaat ggctgacttt gtgttaacta gtataattgc
    13861 tcgtattgct gtgccattct tttttatgct atcaggcttt tttctaattt caacatataa
    13921 ttataattgt aataaactga aatcttttct aaaaaatgta ttatttattt acgggatagc
    13981 tattgtaatt tatattccct taaatattta cactggatat ttttccatga ataatttagt
    14041 gcccaatatt attaaggaca ttgtatttga tgggacttta tatcatttat ggtatcttcc
    14101 tgcatcaatt attggtgcaa gtattgcata ctttcttgta aaaaaactag gtttaaagta
    14161 ctcactagta atcactattg ttatttatgt aattggtatg tttggtgata gttattatgg
    14221 ttttttagaa aaaataccac tattaaagaa tttatatggg tatatttttg aagtatcaga
    14281 ttatacacga aatggtatat tttttgcacc tgtatttttc atacttggtg gaataatatc
    14341 taataaatct aattatatgt caactaaaaa tagcttgatt ggatttctta tatcattctt
    14401 acttatgtta tgtgagggaa tgtttttaca taaactaggg gtacagcgtc atgatagcat
    14461 gtatattatg ttattgccat gtatgtattt cttatttaca gccttaacat ttttgaaagg
    14521 ttctcgagct aggttattgc gaacatcatc attaattatt tatattatac atcctatgat
    14581 gattgttgtt attcgtatgt tttctaaaat attcggaata caaactgtct tggttgacaa
    14641 tagccttatt cattatatag tggtaagtat agcatctttt atagcttcta taattattat
    14701 attgattctt aaacctctaa aaaaagactt gaaaggagaa cataaggtaa ataccaatag
    14761 agcttggatt gaaattgatt taaataattt ggaacataat gtaaagatga tacaaaaagc
    14821 tatgccagaa gattgtgaat tgatggcagt tgtaaaagct aatgcctatg gtcatagtgc
    14881 ttttgaagta gcgacttgtg caaaccaaat aggtgtaaaa gcatttgcag tagcaacaat
    14941 agatgagggg attgatttac gtcgatatgg aatactagga gaaatattga ttcttggata
    15001 tactaaccca ataagggcaa aggaacttca taaatacaat cttacacaga gtgttattga
    15061 ccttaatcat gctatctctt taaacaaaca gaaatacaac ataaaatcac acattaaaat
    15121 tgatacaggt atgcacagac tgggttttga tgttaatgat gtgaggtcaa ttttaaaggc
    15181 atttaaatta aaatacttag atatatgtgg catatttaca cacttgtgtg tttcagatag
    15241 tctgaaagat gaagatgtag actttacaaa taaacaaatt gaatgttttt ataagttaat
    15301 tgattttctg ttaaaaaaag gtataaaaat tcctaaagta catattcaaa gtagttatgg
    15361 tttttttaat tatcccaatc ttaagtgtaa ttatgtaaga attggaattg cattatacgg
    15421 gatattaagt tttccaaatg atacgactaa attgcaactt gatttacgac ctgttttatc
    15481 cttaaaatca caagtaattc ttattagaaa aatacaaaaa gatgatagtt ttggatatgg
    15541 aagagtcttt attgcaagca gagatagcgt aattgctata ttatctattg gctatgccga
    15601 tggtatacct agaaatttat cctgtggaaa aagttacgta ataataaatg gttgtagagc
    15661 agcaatagtg ggtcgaattt gcatggacca acttgctgtt gatattacag atatacctaa
    15721 tgtagaagtt ggtaatacgg caataataat aggaagagat aatttatctg aattatctgt
    15781 ttctgaagtt gcaaataact catgtagtat atcgaatgaa ttattgagca gagtaggaag
    15841 aaggttaaat gttataaaga agtaactcaa ttaaatagta atatttgttg tactgtgtaa
    15901 tttattttac tctgactaga catttttagt aatattatgt ctaatatata ttttttataa
    15961 cttacatgac aatttaagtt ataaaaaggt gatgtttcag atttttattt tgaaacatca
    16021 ccttttttgt tataatatat aataaaataa ttatacctta actgtaaact tatatagatt
    16081 atttactttt taatattaga ttcatttttt gagattggta tataataaac atatagagta
    16141 tataataata gttaaagtta aaaaagggga aaagcaatat gcagtatata caagaactac
    16201 ttgatttgac tcaaaattat tgggtgttag ccacaataat cggcttatta agtgcattta
    16261 tagaaagctt tataccagcc ttaccacttg ttgctatagt tacagcaaat gctgcaatac
    16321 aaggattatt tattggatgt ttgttatcat ggattggctc aggacttggg acaacttcat
    16381 tattcttatt aataagcaga tttaatgata gtaagctttt taataagttg agaaatagta
    16441 aaactgaaaa agcaataagt tggatggata aacagggatt taagttatta tttatagcgt
    16501 atgcctgtcc atttatgccc ggttgtttag ttactatcgc atcagctttt ggtaaaaaag
    16561 atttaaaaga ttttgtgcca gcaatgttgg caggaaaatt tgtaatgttt atagttataa
    16621 gttacgtggc aagtgatata gaaggtttta taacaagtcc tttaaagata gcatcattta
    16681 tattattggt gtttttgtca tggaagattg gaaatagagt aaataaaaat cttgaaaatc
    16741 ataattatga tttccatcat aaaaaacatc acaatgataa agatgataaa atgatttagc
    16801 ttgtacgaaa taaaacgtat cttaaaatga tttagtacta aattatttta agatacgttt
    16861 tattttttgt attaaggtac aaaattttta gttcttttgt aaactaaaat atataaaact
    16921 tatttatact tagttcaaaa tattgttatt ta
//
LOCUS       DAEPID010000080        16796 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.080, whole genome shotgun sequence.
ACCESSION   DAEPID010000080 DAEPID010000000
VERSION     DAEPID010000080.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 16796)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 16796)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..16796
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.080"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            <1..556
                     /locus_tag="KR257_003043"
     CDS             <1..556
                     /locus_tag="KR257_003043"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728538.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=2
                     /transl_table=11
                     /product="sensor histidine kinase"
                     /protein_id="HBH0031714.1"
                     /translation="KISDDIDSEIFRIENSVEKILYLSRLEDFHKDFLIQEVNIEKII
                     RNIIKKYSKYFISKKIILDLNNLNFKVLSDEKWLYFIFEQLLSNSLKYSSLGDNISIY
                     CKRTKNYLQLRVEDTGCGIKKEDLNRIFNKGFTGNNGRNNSKSTGLGLYLVKELCDKL
                     GHKIDVDSEYNQYTKFTITFKCDL"
     gene            668..1897
                     /locus_tag="KR257_003044"
     CDS             668..1897
                     /locus_tag="KR257_003044"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436742.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="efflux RND transporter periplasmic adaptor
                     subunit"
                     /protein_id="HBH0031715.1"
                     /translation="MSFLKKFKNKRFRNNSFKSNNFRNSSFGSSGFKSKNKGFKNNPF
                     KNKRFKIYAGIAVIILLILGVLAYVDSKNTELQANENFIETYTIPENEKIFINGMVVP
                     KQTKDFNISGDYELSDVNVTNGQKVNQGDLLFTAKNPTIIAEIDSLKSQLSQYKKQKI
                     SLSDIAENKDAIASINAQITALNSQIASLDKKAYDRVTAPFDGTVYLNDQTGNPDQPV
                     SFMTIQGLEFYMKGQASEQDLPKMKIDQMVNILVFSTDQKLTGRISFISDKPSTPNTE
                     MGAQQNTLSYYDINIAFDNQEGLVNGFHLQASLEVANSSFKIPASCVLKDNKHSYVFK
                     DLDGILKKQIVDVASQNDDFAVVRGGLEQGDIIIKHPTKEMKEGDPVQGDGVTAGSNN
                     GDTTPNKKVEEVTMDVN"
     gene            1905..2579
                     /locus_tag="KR257_003045"
     CDS             1905..2579
                     /locus_tag="KR257_003045"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889377.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBH0031716.1"
                     /translation="MLIKLENIQKYYKVGKDELHVLKSLNLEIESGEFVMIMGKSGSG
                     KTTLLNILGFLDVFDEGRYIFDGTDVTNLSENERSVFRNINIGFVFQQFNLIETLNVY
                     QNVELPLIYNKALKKSNREEIVKDKLSSVGLLDKLKQKPLQLSGGQQQRVAIARCLAN
                     DPQIIFADEPTGALDSETSREIMELLTRLNKQGKTIIMVTHDQDLTKYATKVIRLKDG
                     VFTSEV"
     gene            2582..3814
                     /locus_tag="KR257_003046"
     CDS             2582..3814
                     /locus_tag="KR257_003046"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420052.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBH0031717.1"
                     /translation="MSLLKNSLANLKGHKLRVFVALLWIIIGITSVILVSSIGNGFQK
                     EIKKSVNNVNPNKTTISFESADNTGLTDDMSIFLKPFNAKDLEELSFVEGVERIAPSR
                     DGFNLDSVYSSQASFDKKTTYVDVGPVKKDSKINLICGRDFSLDDEKRKVILLTLQST
                     SEIFENPEDALGHGININGTIFEIIGVLDDSQQNQAGGFFGGYQDMQFTTSLVPKKAF
                     DTLMSQNSYSNEIYQLDLVSSKGYNVNEVANNVIAKLYEMHPGINGSYTTPDPTEQTA
                     YLESINSNVNKYVSIITVVAMFVGGIGVMNIMYVSVMERQREIGIRRAIGAKPRSILF
                     QFLVEAVFITVCGGILGTIVGFAATNYVSKYIGFEAIPSLNSLFYAIVATILTGVVFG
                     LIPAFKASKLDPIKAIYK"
     gene            complement(4100..5365)
                     /locus_tag="KR257_003047"
     CDS             complement(4100..5365)
                     /locus_tag="KR257_003047"
                     /EC_number="3.5.2.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420051.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dihydroorotase"
                     /protein_id="HBH0031718.1"
                     /translation="MILIKNGRVIDPKSQRDENIDLIIKENKIYKIGKFDESDEYEKI
                     IDASGNVVAPGLVDVHVHFRDPGFTYKEDIESGAKSAARGGFTTVICMANTNPIVDNE
                     DTFNYVKEKSKNACINVLQAAAITKGFEGKELVDMEALKKAGVPGFTDDGLPLMDSNL
                     IMEAMIKAKELDVPLSFHEEDPSLVGNPGVNAGKVASELGLKGASSVAEDVMVARDCM
                     LALKTGAKVDIQHISSGVSVDMVRFAKYLGANVVAEASPHHFTLTEEDVLEFGTNAKM
                     NPPLRSKWDRDKIIEGLNDGTIEIIATDHAPHSKEEKDREFIKAPSGIIGLETSLALG
                     ITNLVHKNHLSMMQLIEKMSINPAKLYNLNIGFIEEGAVADIVIFNPEEEWTVESFVS
                     KADNSPFKGKSLYGKVNYTICNGEIVYNA"
     gene            complement(5418..6566)
                     /locus_tag="KR257_003048"
     CDS             complement(5418..6566)
                     /locus_tag="KR257_003048"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429751.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF362 domain-containing protein"
                     /protein_id="HBH0031719.1"
                     /translation="MKSVSVRSCKTYNYEEVKLSIEKNLEDIGGIDKFVKKGSKVLIK
                     PNLLMKKKPEEATTTHPMVVKVVCEKLLELNCDITIADSPGGPYNQSSLKSIYKASGI
                     EEVANELGIKLNYDVSDVKIHSEKAHVLKYMDIIKPIVDSDYIINLCKLKTHIMATFT
                     GGTKNLYGCIAGLKKAEIHYRFPTEELFCENVLLDICDYIKPTLTIMDGIVGMEGDGP
                     SAGTTREIGVLLASQNPYAIDVVACKIISLLPNKVATIRGAIKRGYIQEDFSDIEILG
                     EDIKDLIIKNYKIPNVSKDLRLFSVKLPKFLNEPISKLITPKPVVRFQDCIKCGKCKE
                     ACPASTIEIGTKGAIIDLSKCIRCYCCHELCPKKAIDVKRNFVFKYVK"
     gene            complement(6666..7211)
                     /locus_tag="KR257_003049"
     CDS             complement(6666..7211)
                     /locus_tag="KR257_003049"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012816134.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NADH peroxidase"
                     /protein_id="HBH0031720.1"
                     /translation="MKKFVCTVCGYIHEGDAAPAQCPVCKVGADKFEEMKGEMVWADE
                     HRIGVAQGVDAEIIEGLRANFTGECTEVGMYLAMSRQADREGYPEVAEAYKRIAFEEA
                     EHAAKFAELLGEVVVADTKENLRVRVDAEYGATDGKLKLAKRAKELGLDAIHDTVHEM
                     CKDEARHGKAFLGLLNRHFGK"
     gene            complement(7434..8378)
                     /locus_tag="KR257_003050"
     CDS             complement(7434..8378)
                     /locus_tag="KR257_003050"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902550.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DMT family transporter"
                     /protein_id="HBH0031721.1"
                     /translation="MQKNKKEGALLKKYFGEIGLIFIAIIWGSGFVATQFALDGGLTP
                     LQIITLRFFLAAIIMNLLFFKQIRANMGKKLLKAGGILGIFLFLAFTVQTIGLMYTTP
                     SKNAFITAANVVIVPFIGFILYRRKLDKIGIISSLVALIGIGILSLEADFSINFGDFL
                     TLICSFGFAFHIFFTSEFAKDNNPMALTAIQFTVAFLMSVVVQTFAGQLKMEAELSGY
                     MGTMYLAVFSTTIGFLFQTICQKRVDGTRTAIILSTEAVFGTIFSIIILKELITAKLV
                     IGSILIFVAIITAETKLSFLKSKKVKLKDSEESSLESI"
     gene            8764..9645
                     /locus_tag="KR257_003051"
     CDS             8764..9645
                     /locus_tag="KR257_003051"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420045.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="polysaccharide deacetylase"
                     /protein_id="HBH0031722.1"
                     /translation="MVKKRKKKTVTLTILVVIVIGIFSMAWADMSRKKEMKETQERLK
                     AERLEKERIEKEKNEPIIGAKKEAVKEYGYDAKIVWDKLNKYDYSNNGEKIVFLTFDD
                     GPSTTNTPQVLDILKRHGVRGTFFIKGDSLERKGANEILKRTFDEGNAIAHHSYTHDY
                     KKLYPNRSLNLDTFVNELNKTDEAMKKVLGKNFSSNVVRCPGGYMSWKNMEPLGNYLK
                     EKNMASIDWNALNADAEGKKKNAQELFEHAKKSSEGKEMVVLLMHDTYGKQETVNALD
                     QIITYFKDNGYQFKILI"
     gene            complement(9706..10914)
                     /locus_tag="KR257_003052"
     CDS             complement(9706..10914)
                     /locus_tag="KR257_003052"
                     /EC_number="6.1.1.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420043.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tyrosine--tRNA ligase"
                     /protein_id="HBH0031723.1"
                     /translation="MKSIDEQMRIIMKGVDDLIDEKELREKLIKSEKEGKPMIVKLGL
                     DPSAPDIHLGHTVVLRKMKQLQDLGHQIVIIIGDFTGKIGDPTGKSKARKALTTEQVL
                     ANAKTYEEQIFKVLDKEKTIVRFNSEWLAKLNFEDVIKLAATITVARMLEREDFKKRY
                     EGQMPISVHEFFYPLMQAYDSIALEADIELGGTDQRFNLLMGRSLQREFGMESQIVIM
                     MPLIEGLDGKEKMSKSLGNYIGIDEEAGIMYQKSMEIPDELIIKYYNLVTDVHPDEVN
                     KIESQLKEGSVNPRDIKMNLAREIVTLYHGEESAKEAEERFKSVFQKGQIPEDIQTIQ
                     VKEDGFDLIEVLVSNEIVKSKSEVRRLASQGGVKVNGEKVEDLSTIVKESELVVQIGK
                     KKFVKIELVK"
     misc_binding    complement(10987..11239)
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00230"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="T-box leader; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /bound_moiety="tRNA"
                     /db_xref="RFAM:RF00230"
     gene            complement(11391..12380)
                     /locus_tag="KR257_003053"
     CDS             complement(11391..12380)
                     /locus_tag="KR257_003053"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003439382.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF2232 domain-containing protein"
                     /protein_id="HBH0031724.1"
                     /translation="MIYGGSVLNTTKKLTEAALLSSLFIVVTIIAVSTGFGYAIYLDF
                     IVPVFFCIICLKCDLKYTILSGITSLLIISLVLGNLGTAIWASQSVLLGIMCGYLINK
                     PTMVMDDLVYGSVFGVIVMVFIDIYASTLIGYSFMKEFQGYSKWIYFNGYTNFIYYLM
                     IALFPFGMVFCIYLLSLILGNKLHILDSNSLKKFLIFKNFRNLNQFLCCSKKAFYICV
                     SYLAIFEVLKLLNVKVDSVYLKTIFISITYISVYFIIRDSCMSLQNFIIAKFRKLLYA
                     RILFLIIILLLFFIFDVTVISLIIINAFLNKKINIRLSQSNIVNKQINLLIEK"
     gene            12532..12972
                     /locus_tag="KR257_003054"
     CDS             12532..12972
                     /locus_tag="KR257_003054"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003427501.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HBH0031725.1"
                     /translation="MFKIKHFNDLSLDEFYEIAKSRYEVFACEQKIFSLNDYDDIDKS
                     SYHIFLKENGLICAYARIIPKEYSSYNDVSIGRVLVLSSHRRKGLAKQMMDCAIDFIK
                     VNLHENNITLSAQTYIKNLYLSCGFKEISEVYDEAGIEHIKMRL"
     gene            13299..13526
                     /locus_tag="KR257_003055"
     CDS             13299..13526
                     /locus_tag="KR257_003055"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420037.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ferrous iron transport protein A"
                     /protein_id="HBH0031726.1"
                     /translation="MKNLNDIQVKKTVKVEDILSSGNLRERMLALGLTRGAVIDVVRK
                     GPKNNLTVYKIRGSKIALRQEESSLILVSDI"
     gene            13552..15672
                     /gene="feoB"
                     /locus_tag="KR257_003056"
     CDS             13552..15672
                     /gene="feoB"
                     /locus_tag="KR257_003056"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003439379.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ferrous iron transport protein B"
                     /protein_id="HBH0031727.1"
                     /translation="MGLTHNSTKMSSLKDMFDIDNKEDQFVIALAGNPNTGKSTVFNH
                     LTGLRQHTGNWPGKTVATARGNFKYKNTEYALIDLPGTYSLFALSQEEIVARDFICFG
                     NPDAVIVVCDATCLERNLNLVFQVMELTDKVILCINLIDEARKKGITIDKKLLEDSLG
                     IPVILTAARNGSGMDELLDTLNDVSFDKYKLNNKPVRYNENIENVVKSIQPELDNIIP
                     GINSRWLGLRLIDGDESIFESMSNYIDKDSIDAINEVKKKIPDNINKQKIRDEFTKIN
                     YDYAKKLSDECCSNVAKKSTDREEKVDKILTSKIFGLPIMLLLLGTILWITIEGANYP
                     STLLSNLLLGFEPSISGILNSINCPSWLNDMLVLGLYRTLAWVISVMLPPMAIFFPLF
                     TLLEDFGYLPRVAFNLDHLFKKACAHGKQCLTMCMGFGCNAAGVIGCRIIDSPRERLI
                     AILTNNFVPCNGRFPTLIAISTIFFSSVITNSFVSSVATALCITLLIILGVIITLLVS
                     YTLSKTLLKGVPSTFTLELPPYRVPQIGRTLYTSIIDRTIFVLGRAVMVAIPAGVITW
                     IFANIYIGDLSILSHVANFLDPLAKLIGLDGFILLAFILGFPANEIVVPILLMAYLAT
                     GSMIELDSFSALGQVLREHGWTYLTALNVMLFSLLHWPCATTLLTIKKETGSLKWTAL
                     GFLMPTILAFVVCFLTTTVYNLFI"
     gene            complement(15805..16623)
                     /locus_tag="KR257_003057"
     CDS             complement(15805..16623)
                     /locus_tag="KR257_003057"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893097.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MerR family transcriptional regulator"
                     /protein_id="HBH0031728.1"
                     /translation="MEKQYFTTGEFAKLCGISKQTLIFYDKIGIFSPEYKDKNNYRYY
                     SVYQYDTLDILQSLREIGMSLEEIKEYIQNRTPQLCVKMLKEEEKKIREKIKKLRKIS
                     SKMQNRINITVEGISKMNSEEIYISKKFEEYLVLSSDLSNMSNSDFMMELIDFTNYCK
                     SKNLYQGYELGVIVSNENIKNGDYLSISSFYLKIDKKIKDKKLYVKPEGMYACIKHIG
                     KYEDSYKSYEKLKKYIYENEYKIVGNSYEESILDFFCESNEDNYMTEISIQVSR"
BASE COUNT         5881 a         2589 c         2189 g         6137 t
ORIGIN      
        1 aaaaatttca gatgacatag atagtgaaat atttagaatt gaaaactccg ttgaaaaaat
       61 tttatattta tcaagactcg aagattttca taaggatttt ttaattcaag aggtaaatat
      121 tgaaaaaatc attagaaata ttataaaaaa atactcaaaa tattttattt caaaaaaaat
      181 tattttagac ttaaataatt tgaattttaa ggttttatct gatgaaaaat ggctatactt
      241 catattcgag caattattga gtaattccct aaaatactcc tcattaggag ataatatatc
      301 tatctattgc aaaagaacca aaaattattt acaattaaga gtggaagata ctggttgtgg
      361 tataaaaaag gaagatttaa atcgaatatt caataaggga tttacaggta ataatggaag
      421 aaacaattct aaatctacag gtcttgggct ttatttagta aaagaacttt gtgataagct
      481 tggtcataaa attgatgtag attcagagta caaccaatat acaaaattta ctattacatt
      541 caaatgtgat ttatagtatc ttattattga tagtttattt tcattaactt atattcaact
      601 tcttatagta attctatatg tacatcccag tatataatta agtagttttt ataaaaagga
      661 ggaagacatg tcttttctaa aaaaatttaa aaataaaaga tttagaaata acagttttaa
      721 aagtaacaac tttagaaata gcagttttgg aagtagtggc ttcaagtcta aaaataaagg
      781 ttttaaaaac aatcccttta aaaataagag attcaaaata tatgcaggaa tagcagtaat
      841 catactttta attctaggag ttcttgctta tgttgattcg aaaaacactg aattacaagc
      901 taatgaaaat tttatcgaaa catatactat tcctgaaaat gaaaaaatat ttataaatgg
      961 gatggttgtt cctaagcaaa ctaaggactt caatatatct ggagattatg agttaagtga
     1021 tgttaatgtt acaaatggtc aaaaagtaaa tcaaggagac cttcttttta ctgctaaaaa
     1081 tccaactata atagcagaaa tagatagttt aaaatcacaa cttagtcaat acaaaaaaca
     1141 aaaaatatca ctttctgata ttgctgaaaa taaagatgct attgcttcta taaatgcaca
     1201 gataactgct ttaaactctc agatagcttc tctggataaa aaagcttatg acagagttac
     1261 tgctcctttt gatggcacag tatacttgaa tgaccaaact ggaaatccag accaaccagt
     1321 ttcatttatg actattcaag gtctagagtt ttatatgaaa ggacaagcaa gtgaacaaga
     1381 tttacctaaa atgaagattg accaaatggt caatatacta gttttttcaa ctgaccaaaa
     1441 gcttactggt agaataagtt ttatatctga taaaccatct actccaaata ctgaaatggg
     1501 agctcagcag aatacactat cttattatga tataaacata gcatttgata atcaagaagg
     1561 attagtaaat ggattccatc ttcaagcatc acttgaagta gctaattcaa gctttaaaat
     1621 accagcatct tgtgtactta aagacaacaa acactcatat gtatttaagg atttagatgg
     1681 tatattgaaa aagcaaattg tagatgtagc aagtcaaaat gatgattttg ctgtagttag
     1741 aggcggtctt gaacaaggcg atataataat aaaacaccct actaaagaaa tgaaagaagg
     1801 agacccagtt caaggcgatg gcgtaactgc tggttctaat aatggagata ctactccaaa
     1861 caaaaaagta gaagaagtta ctatggatgt gaattaattt acatatgtta attaaattag
     1921 aaaatattca aaaatattac aaagtaggga aagatgaatt acatgtttta aaatccttaa
     1981 atttagaaat tgaatctgga gaatttgtca tgataatggg taagtctggt agtggtaaaa
     2041 ctactttact taatatctta ggttttctag atgtatttga tgaaggaaga tatatatttg
     2101 atggaacaga tgtaactaat ttgagtgaaa atgaacgttc tgtttttaga aatattaata
     2161 ttggatttgt tttccaacaa tttaatttaa tagaaactct aaatgtatat caaaatgtag
     2221 agttgcctct aatttacaat aaagcactaa aaaaatctaa tagagaagaa attgttaaag
     2281 ataaattaag ttctgttggg cttttggaca agcttaagca gaaaccactt caattatctg
     2341 gtggtcaaca acagcgtgta gccattgcac gttgcctagc aaatgaccct cagataatct
     2401 ttgctgacga accgactggg gcattagata gtgaaactag cagagaaatt atggagcttt
     2461 taacaaggct caacaaacaa ggtaagacta taataatggt tacacatgat caagatttaa
     2521 ctaagtatgc aactaaggtt atacgactta aagatggtgt gtttacttcg gaggtgtaat
     2581 catgagttta ttaaaaaatt ctttggccaa tttaaaaggt cacaagcttc gtgtatttgt
     2641 agctttactc tggattataa taggaataac ttcagtaata cttgttagtt ctataggtaa
     2701 tggatttcaa aaagaaatta agaaatctgt aaacaatgta aaccctaata aaactactat
     2761 ttcgtttgaa tcagccgata acacaggtct tactgatgat atgagtattt ttttaaaacc
     2821 ctttaatgca aaagatttag aagaattatc atttgttgaa ggagtagaaa gaatagctcc
     2881 ttcaagagat gggtttaacc ttgattcagt ttactcttca caagcatctt ttgataaaaa
     2941 aactacgtat gttgatgttg gaccagtaaa aaaagattct aaaataaatt taatttgtgg
     3001 tagagatttt tctttagatg atgaaaaaag aaaagtaatt ttacttacat tacaaagtac
     3061 aagtgaaatt tttgaaaatc cagaagatgc cttaggtcat ggtatcaaca taaatggaac
     3121 tatatttgaa ataatagggg tattagatga ttctcagcaa aaccaagctg gaggattctt
     3181 tggaggttac caagatatgc aatttactac ttccctagta cctaaaaagg cttttgacac
     3241 tttaatgagt caaaattctt attcaaatga aatttaccag ttagacttag tttcttctaa
     3301 aggctataat gtaaatgaag ttgcaaacaa tgttatagct aaattatatg agatgcaccc
     3361 tggtatcaat ggttcttata ctacaccaga cccaactgaa cagacagctt atcttgaaag
     3421 cattaattcc aatgtaaaca aatatgtatc tataataact gtagttgcaa tgtttgttgg
     3481 tggtattggt gtaatgaata taatgtatgt atctgttatg gaaagacaaa gagaaattgg
     3541 tataagacgt gctattggag caaaacctag gtctatatta tttcaatttt tagttgaagc
     3601 tgtttttata acagtatgtg gtggaatttt aggaactata gttggatttg ctgctactaa
     3661 ctatgtttct aaatatatag gttttgaagc tatacctagc ttaaatagct tattttatgc
     3721 aattgtagct actatattga ctggagttgt atttggtctg attccagcct ttaaagcttc
     3781 taaactagac cctataaagg caatttataa gtagaaattg tataaagatt ttcgattttt
     3841 agattagttt atataaaaca tacttaaata tataacgcac tattatatat gatagattag
     3901 gaacttaatc tttccaaata taatagtgcg ttctttcata aaaaggattc tcttccttac
     3961 tatatctaaa ttaccaagat gttatgttct aattgttcaa actaatactt ccaattttga
     4021 ttaatcaatc tcattctcct aatatacaat cttttacttt caatcattgt acactccgcc
     4081 ttaaaaaaat aatcttaaat taggcgttat atacaatctc cccattacat attgtataat
     4141 taacctttcc atataaagat ttacctttaa atggtgaatt atcagcttta gaaacaaagc
     4201 tttcaactgt ccattcttct tctggattga atataacaat gtctgctaca gccccttctt
     4261 ctataaatcc aatatttaaa ttgtacaatt ttgcaggatt tatagacatt ttttctatta
     4321 actgcatcat actaagatga tttttatgca ccaaatttgt tattccaaga gctaaagaag
     4381 tttcaagccc aataattcca cttggagctt ttataaactc tctatctttt tcttctttac
     4441 tatgaggtgc atggtctgtt gctattattt caatagtacc atcatttaat ccctctataa
     4501 tcttatctct gtcccattta cttcttagag gtggattcat ttttgcattt gttccaaact
     4561 ccaatacatc ttcctcagtc aatgtaaagt gatgtggtga agcttctgca actacatttg
     4621 cacctaagta ttttgcaaat ctaaccatat caacagatac acctgaactt atatgttgta
     4681 tatcaacttt agcaccagtc tttagtgcca acatacaatc tctggctacc ataacatctt
     4741 ctgctacact tgatgcacct tttaatccaa gttctgaagc tacctttcct gcatttacac
     4801 ctggatttcc aactaaagaa gggtcttctt catgaaaact aagtggtaca tccaactctt
     4861 ttgccttaat cattgcctcc ataattagat tgctatccat taaaggtaat ccatcatcag
     4921 taaaccctgg tacaccagct tttttaagag cttccatatc aactaactct ttaccttcaa
     4981 aacctttagt tatagctgct gcttgtaaaa catttataca tgcatttttt gacttttctt
     5041 taacataatt aaaagtatct tcattatcta caataggatt agtatttgcc atacatataa
     5101 cagttgtaaa tccacctcta gcagcagatt tagctccact ttctatatct tctttatatg
     5161 taaacccagg gtctctaaag tgtacatgta catccactaa acctggagca actacattac
     5221 cactagcatc tattattttt tcatattcat cactttcatc aaacttgcct attttataaa
     5281 ttttattttc ttttataatt aagtcaatat tctcatctct ttgactttta gggtctatta
     5341 ctctaccatt tttaattaaa atcatattat ttctccttta tatttttaat ttatatagac
     5401 tcatataata ttatacatta ttttacatac ttaaatacaa aattacgttt gacatcaata
     5461 gcctttttag gacaaagttc atggcaacag taacatctta tacatttact taagtctata
     5521 atagcaccct tagtccctat ctctatagtg gatgcaggac aagcttcctt gcattttcca
     5581 cattttatgc aatcttgaaa tcttaccaca ggctttggtg ttataagctt tgaaataggt
     5641 tcatttaaaa attttggtag ctttacggaa aacaatctta aatctttact tacatttgga
     5701 atcttgtaat tttttataat taaatctttt atatcttcac ctaaaatttc aatatctgaa
     5761 aaatcttctt gtatatatcc tctcttaata gcacctctaa ttgtagcaac tttatttgga
     5821 agtaaactta taatcttaca tgcaacaaca tctatagcat atggattttg tgatgctaat
     5881 aaaactccta tttctcgagt agtaccagct gaaggtccat caccttccat acctactata
     5941 ccatccataa ttgtcaatgt tggttttata taatcacaaa tatctaaaag tacattttcg
     6001 caaaacaact cttctgtagg aaatctataa tgtatctctg cttttttcaa tccagctatg
     6061 catccatata agttttttgt accaccagta aaagttgcca ttatatgagt ctttaattta
     6121 caaagattta ttatataatc tgaatctact attggtttaa taatatccat atattttaga
     6181 acatgtgctt tttcactatg tatcttaaca tctgaaacat cataatttaa cttaatgccc
     6241 agttcatttg ctacttcttc aattccagat gccttataaa tgctcttaag agaactttga
     6301 ttatatggac caccagggct atctgctatt gtaatatcac aatttaactc taaaagtttt
     6361 tcacatacaa cttttacaac cataggatgt gtagttgtag cttcttcagg cttttttttc
     6421 attaataaat ttggttttat aagtactttg cttccttttt taacaaactt atctatacca
     6481 ccaatatcct ctaaattttt ttcaatagat aactttactt cttcataatt gtaagtttta
     6541 caactcctaa cagataccga cttcatatta tctccatcct tctatcacaa cagtttattt
     6601 atataattta aaaaaggaga aaccaaagtt tctcctttta atctatgttt taattgtttt
     6661 aattattatt ttccaaaatg tctgtttaat aatcctaaga atgctttacc atgtctagct
     6721 tcgtctttac acatttcatg tactgtatca tgtatagcat ctaatcctaa ttctttagct
     6781 ctcttagcta attttaattt tccatcagtt gcaccatact cagcatcaac tctaactctt
     6841 aagttttctt ttgtatctgc aactacaact tctccaagaa gttctgcaaa tttagcagca
     6901 tgttcagcct cttcaaaagc tattctctta tacgcttcag ctacttctgg ataaccttct
     6961 ctatcagctt gtctactcat tgctaaatac attcctactt ctgtacactc accagtaaag
     7021 ttagctctta atccttcgat tatttctgca tctacacctt gagctactcc tattctatgt
     7081 tcatcagccc aaaccatttc gcctttcatt tcttcaaatt tatcagctcc aactttacat
     7141 actggacatt gtgctggtgc agcatctcct tcatgtatat atccacatac tgtacaaaca
     7201 aattttttca taattaattt cctcccaatt ttatataatt aaatttttat ttttaagttt
     7261 aataacttgc tacaagaata tatatacccc agactttata gcttaaacac taaaaataaa
     7321 atttatttcc taattaattt tatcactttg aaacaccagt atcaaccaag ttttgatgtc
     7381 aaatttctac ataatacata atttatttga ttaattagga aatagttgtc atattaaata
     7441 ctttctaatg aagactcctc tgaatcttta agtttcactt ttttgctctt taaaaaagat
     7501 aatttagttt ctgcagttat gattgcaaca aatatcaaga tactaccaat aaccaatttt
     7561 gctgtaataa gctcctttaa aattattata gaaaatattg taccaaatac agcctctgtg
     7621 gataatatta tagctgttct agttccatca actctttttt gacatatagt ctgaaataaa
     7681 aatccaattg tagtactaaa tacagctaga tacatagttc ccatgtaacc agataattca
     7741 gcttccatct ttaattgacc tgcaaatgtt tgaactacaa cagacattaa aaacgctact
     7801 gtaaattgaa tagctgtcaa tgccattggg ttgttatctt ttgcaaactc acttgtaaag
     7861 aatatatgaa atgcaaatcc gaatgaacat ataagtgtta gaaaatctcc aaaattaata
     7921 gagaaatcag cttctaaaga aagtatccca attcctataa gagctaccaa actacttatt
     7981 attcctattt tatcaagttt tcttctataa agtataaatc ctatgaatgg aactattaca
     8041 acattagctg ctgttataaa cgcattttta gatggtgtag tgtacataag tccaatagtt
     8101 tgtactgtga atgctagaaa taaaaatatt cctaaaatcc ctcctgcttt taataatttt
     8161 ttacccatat tggcacgaat ctgtttaaaa aacagtaaat tcataattat agctgccaag
     8221 aaaaatctta aagttatgat ttgtagaggt gtaagcccac cgtctaatgc aaattgggtt
     8281 gctacaaagc cacttcccca tataattgct ataaatatta gtcctatttc tccaaagtat
     8341 tttttcaata aagctccctc ctttttattt ttttgcaaaa ttataaaccc cctaaacagc
     8401 aagagagttt ttctataagc attactataa attaatatag taaatttttt cagtatttta
     8461 aatctaaatt tacatacatt ttgagctcaa atttatatcc actatttaac agtaatatat
     8521 taatcatttt ttgtaaacac ctttttaata aatttttata ttttttatat ttttttacct
     8581 atactaaatt tttttataga tatttttaat atatatgata ctttaatatt atgcaaataa
     8641 tgtcatataa gttacacttt agttatctta gttacaactt tgtcggttta ctttttctac
     8701 tttcttcgat ataattataa tatatttttg atacaattcg acaaaagggg gaatgctgta
     8761 attatggtaa aaaaaagaaa aaagaaaact gttacactta ctatacttgt tgtaatagtt
     8821 attggtattt tttctatggc atgggcggac atgtctagaa aaaaagaaat gaaagaaact
     8881 caagaaagac ttaaagctga aagattagaa aaagaaagaa ttgaaaaaga aaaaaatgaa
     8941 cctattattg gtgcaaaaaa agaagctgta aaagaatatg gatatgacgc aaaaatagtt
     9001 tgggacaaac ttaacaaata cgactattca aacaatggag aaaagatagt ctttcttaca
     9061 tttgatgatg gaccatctac tactaatact ccacaagttc tagatatctt gaaaagacat
     9121 ggtgttagag gaactttctt tattaagggt gattctcttg aaagaaaagg agctaatgaa
     9181 attttaaaaa gaacatttga cgaaggaaat gcaatagccc atcactctta tactcatgac
     9241 tataaaaaac tatatcctaa cagaagccta aatctcgata cattcgtaaa tgaacttaac
     9301 aaaactgatg aagctatgaa aaaagtctta ggaaagaatt tttcctcaaa tgtagttaga
     9361 tgcccaggcg ggtacatgtc atggaaaaat atggaacctc taggaaacta cttaaaagag
     9421 aaaaacatgg catcaattga ttggaacgct ttaaatgctg atgcagaagg taaaaagaaa
     9481 aatgcacaag aattatttga acatgcaaag aaatcttctg aaggcaaaga aatggttgtt
     9541 cttttaatgc atgatactta tggaaaacaa gaaacagtaa atgcattgga ccaaattata
     9601 acatatttta aagacaatgg ttatcaattt aaaattttaa tataataaaa aagcaagttt
     9661 attgaatgta cattttatac tcaatagact tgcttttact ttactctatt ttactagctc
     9721 gatttttaca aattttttct ttcctatttg aacaactaat tcactctctt ttacaatagt
     9781 gcttaaatcc tctacttttt caccatttac ctttactcca ccttgagaag ctaatcttct
     9841 aacttcactc ttactcttaa caatctcatt agaaactagt acttcgatta agtcaaatcc
     9901 atcttcctta acttgaattg tttgtatatc ttcaggtatt tgaccttttt ggaatacaga
     9961 tttaaatctt tcttcagctt ctttagcaga ttcttctcca tggtataatg ttactatttc
    10021 tcttgctaag ttcatcttta tatctcttgg atttactgaa ccctctttca actgagattc
    10081 tattttatta acttcatcag gatgaacatc tgtcactaaa ttgtagtatt taattataag
    10141 ttcatcagga atttccatag atttttggta cattattccc gcttcttcat ctattccaat
    10201 atagttacct aaactcttac tcattttttc tttaccatct aatccttcta ttaaaggcat
    10261 cattattact atttgagact ccataccaaa ttctctttgt aatgatcttc ccattagtaa
    10321 attgaatctt tggtcagttc caccaagttc tatatcagct tctaatgcta tagagtcata
    10381 tgcttgcatt aatgggtaga agaactcatg tactgatatt ggcatttgtc cttcatatct
    10441 ctttttaaaa tcttctcttt ctaacattct cgcaacagta atagttgctg ctaattttat
    10501 tacatcttca aaatttaact tagctaacca ctcgctatta aatcttacaa tagttttttc
    10561 tttatctaaa actttgaaaa tttgttcttc ataagttttt gcatttgcaa gaacttgctc
    10621 tgttgttaaa gcttttctag ctttagattt tccagttggg tctccaattt ttcctgtaaa
    10681 atctccaatt attattacta tttgatgacc taaatcttgt aattgtttca tctttctaag
    10741 aactactgta tgccctaaat gtatatctgg agcacttggg tctagaccca attttactat
    10801 cataggcttt ccttcttttt ctgatttaat aagcttttcc cttaactctt tctcatctat
    10861 taaatcatct acacctttca taattattcg catttgctcg tctatcgatt tcatttttca
    10921 ttcctcctaa aatatttata taatctataa tttttatttt tataataaaa aaagctttca
    10981 tcctcttaaa aggacgaaag cattgcttac gtgttaccac cttagttcat caatatctca
    11041 cgatattaat ctcttagagt acaattacat atactcgtgt actataacgt gtactaatcc
    11101 gatatctctt aatggttgtt atctttcaga gatagtgctc tgagatgtat tcaaactaaa
    11161 tcaatttatt ccatttcacc aaactggaac tctctgttaa ataaaatcta gccctacttc
    11221 ttctcttcat agcatttata tattcagatt atttcatcaa ttacaagaaa tttttcttaa
    11281 cttactcata atatattatt atttttatat tttgtcaacc ttttttatta ttatatacat
    11341 gtttttttac attatactac ttttttatat tttttaccaa tacccaaaat ttatttttca
    11401 atcaaaagat ttatttgttt attgactata ttactctgac tcaatcttat atttattttc
    11461 ttatttaaaa atgcgtttat aattattaaa ctaataactg ttacatcaaa tataaaaaac
    11521 agcaataaaa ttattatcaa aaataaaatt ctagcatata ataattttct aaacttagct
    11581 attataaagt tttgtagtga catacatgag tctctaatga taaaatagac acttatatag
    11641 gttattgata taaagattgt ttttaaataa acagaatcaa ctttaacatt caacagtttt
    11701 agaacttcaa aaatggctag ataagaaaca catatgtaaa aagctttttt tgagcaacat
    11761 aaaaattggt ttaaatttct aaagttctta aatattaaaa atttttttaa agaattagaa
    11821 tctaaaatat gcaatttatt ccctaaaatt aaacttaata aatatatgca aaacaccata
    11881 ccaaaaggaa acaatgctat cattaaataa taaataaaat ttgtataccc attaaaataa
    11941 atccatttgc tatatccttg aaattctttc ataaaactat aacctattaa tgttgaagca
    12001 tatatatcaa tgaaaaccat tacaataacc ccaaatactg aaccatatac taaatcatcc
    12061 ataaccattg taggcttatt tattagatag ccacacatta taccaagtaa tacactctga
    12121 cttgcccaaa tagcagttcc tagatttcca agtaccagag aaattattaa aagcgaagta
    12181 attccagata aaatggtata ctttaaatca catttcaagc agattataca aaaaaatact
    12241 ggcactataa aatctaagta aatagcatat ccaaatccag tactcacagc tataattgtt
    12301 actactatga ataaagatga caataaagct gcttcagtta attttttagt agtattcaaa
    12361 acactgcctc cataaatcat aaattttcta actaaagttt tgtttttaat atagtatatc
    12421 actttttaaa aatattttta ataaatataa attttaataa aggtatttat gttaaaaatg
    12481 gtataatgta tcttaatatt cagtttttta agatgctagg aggtaattac tatgtttaaa
    12541 attaaacact ttaatgattt gagtttagat gaattttatg aaatagcaaa atcaagatat
    12601 gaggtatttg cttgtgaaca gaagatattt tcattaaacg attatgatga tatagataaa
    12661 agctcttatc acatattttt aaaagaaaat ggattgattt gtgcttacgc tagaataatt
    12721 cctaaagaat acagctctta taatgatgtt tccattggta gagttttagt tctttctagt
    12781 catagaagaa aaggattagc aaaacaaatg atggattgtg ctatagattt tataaaagtt
    12841 aacttacacg aaaataatat aaccttatca gcacaaactt atataaagaa cctttactta
    12901 tcttgtggtt ttaaagaaat ctcagaagta tacgacgaag caggtattga acatattaaa
    12961 atgagattat agtgttgaca agctaatatt gttaatatat aatttaagta taaattaaat
    13021 attgaattga tatttaggta tttgaaaata ccttacatag agtcagaagg cttttgcttt
    13081 ctgacttttt tattatcaaa attcaataat tatatggatt caaagtgtta atttttattc
    13141 tatattctac tttccccaaa agtaagaatt atacccaact ttgtatgata ggcatcttgc
    13201 ctatcttttt tttgtaaaag taacaaggta ataatataat gcatagttta aaataagaag
    13261 attagcccag gctaaatttc aagcatggag gtgctattat gaaaaacctt aacgatattc
    13321 aagtgaaaaa aactgtcaaa gttgaagata tattatctag tggtaattta agagaaagaa
    13381 tgttagcgct tggtcttact agaggagctg ttatagatgt agttagaaaa ggtccaaaaa
    13441 ataatttaac tgtctataaa atcagaggta gcaagatagc tctacgacaa gaagaaagta
    13501 gcttaatatt agtttctgac atttaaaaat ttctagcagg aggatattaa tatggggttg
    13561 acacataact caactaaaat gagttcttta aaagacatgt ttgatataga caataaggaa
    13621 gaccagtttg taattgcatt ggctggcaat ccaaatacag gtaaaagtac tgtatttaat
    13681 catcttacag gacttagaca gcatactgga aactggccag gaaaaactgt agctacagct
    13741 cgtggtaatt ttaaatataa aaataccgaa tatgcattaa tagatttacc aggaacatat
    13801 tctttatttg ccttatcaca agaagaaatt gtagctcgtg attttatatg ttttggtaat
    13861 ccagatgcag taatagtagt atgtgatgct acatgtcttg aaagaaattt aaatttagta
    13921 tttcaagtga tggaacttac agataaagtt attttgtgta ttaatttaat agatgaagct
    13981 agaaaaaaag gcattactat tgataaaaaa cttttagagg attctcttgg tattccagtt
    14041 attttaactg ctgcaagaaa tggctctggt atggatgaac tattggatac tttaaatgat
    14101 gtatcttttg acaaatataa attaaataat aaacctgtta gatacaatga aaatatagag
    14161 aatgtggtaa aatcaattca accagaattg gataatatta taccaggtat aaattctaga
    14221 tggttgggac ttagacttat tgatggcgat gaaagtatat ttgaatctat gagtaattat
    14281 atagacaaag attctataga tgctattaat gaagtaaaga aaaagattcc agacaatata
    14341 aataaacaga aaataagaga tgagtttact aaaatcaact atgattatgc taaaaaactg
    14401 agtgatgagt gttgttctaa tgttgctaaa aaatcaactg atagagaaga aaaagtagat
    14461 aaaatattaa catctaaaat atttgggctt ccaataatgc tcttattatt aggtactata
    14521 ttgtggatta ctatagaagg agctaactat ccatccactt tattatctaa tttattactc
    14581 ggatttgagc caagtatttc gggtatatta aatagtatta attgtccatc atggttaaat
    14641 gatatgttgg ttttaggatt atacagaaca ttagcatggg taatctctgt aatgctacct
    14701 cctatggcaa tattttttcc attatttacc ctacttgagg attttggata tttgccaaga
    14761 gttgcattta acttagacca cctatttaaa aaagcttgtg cacatggaaa acagtgtttg
    14821 actatgtgta tgggatttgg atgtaatgca gctggagtta ttggttgtag gataattgac
    14881 tctccaaggg aaagacttat agctatactt acaaacaact ttgttccttg taatggtcgt
    14941 tttcctactt tgatagctat atctacaata ttttttagct cagttataac caactctttc
    15001 gtatcaagcg tagcaactgc actttgcata actttactga taattctagg tgttataata
    15061 acattgttgg tttcttatac tctttctaaa acgctattaa aaggagttcc gtctacattt
    15121 acattagaac ttcctcctta tagagttcct caaataggaa gaactttata tacctctata
    15181 atagatagaa caatatttgt tttaggaagg gctgtaatgg tagccatacc tgctggtgtc
    15241 ataacttgga tatttgcaaa tatatatata ggagatttaa gtatattatc acatgttgca
    15301 aactttttag accctttagc taaattaatt ggtcttgatg gttttatatt acttgctttt
    15361 attcttggat tcccagcaaa tgagatagtt gtacctatac ttttaatggc ttacctagca
    15421 actggttcta tgatagaatt agatagcttt agtgctttag gtcaagttct tagagaacat
    15481 ggatggactt atttgacagc tttaaatgtt atgctgttca gtttactgca ttggccttgt
    15541 gcaacaacac ttttaacaat aaaaaaagaa actggtagtt taaaatggac tgccttagga
    15601 ttcttaatgc ctactatact tgcttttgtt gtttgttttt taacaactac agtttacaat
    15661 ttatttatat aattagtatt aactgacagt agacatatat tagagaaacc atttaaaaat
    15721 ttatatactt tattataaag catagagata tattcaatga taagtaaaat tacttaacat
    15781 ttgaatatat ctctatttta attcttatct ggatacttgg attgaaattt cagtcatata
    15841 attatcttca ttactttcac aaaaaaagtc aagtatactc tcctcatacg aatttccaac
    15901 aattttatat tcattttcat atatatattt tttcaatttt tcgtaagatt tatatgaatc
    15961 ctcatatttt ccaatatgtt ttatgcaagc atacattcct tctggcttta catatagctt
    16021 tttatccttt atttttttat ctatcttcaa ataaaaactt gatatactta aatagtcccc
    16081 attttttata ttttcattac ttactattac tcccaactca tatccttgat acaaattttt
    16141 cgatttacaa taattggtaa aatctattaa ttccatcata aaatcactat tactcatatt
    16201 actcaaatcg cttgatagaa ctaaatattc ttcaaacttt ttggatatat aaatttcttc
    16261 actattcatt ttagaaattc cttcaactgt tatatttatt ctattttgca tcttagaact
    16321 tatctttctt agttttttta ttttttctct tatctttttt tcttcttctt taagcatttt
    16381 cacacaaagc tggggagttc tattttgtat atactctttt atttcctcta aactcattcc
    16441 tatttctctt aatgattgta atatatcaag tgtatcatat tgataaactg agtaatatct
    16501 ataattattt ttatctttat attcaggaga aaaaatacct attttgtcat agaaaattaa
    16561 tgtctgctta gatataccac acaatttagc aaattcacct gttgtaaaat actgtttttc
    16621 caagggttat acactccttt tctttttgtt gtctatatag ttactatatt ctttattatt
    16681 tactaaatca agtagttatt attttagaaa atcaatatgg ttttgatttt aaagcttaaa
    16741 tatcagttag atgtcagtta taaatatttt acccattccc atcataaaaa agatat
//
LOCUS       DAEPID010000081        16763 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.081, whole genome shotgun sequence.
ACCESSION   DAEPID010000081 DAEPID010000000
VERSION     DAEPID010000081.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 16763)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 16763)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..16763
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.081"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            complement(276..446)
                     /locus_tag="KR257_003058"
     CDS             complement(276..446)
                     /locus_tag="KR257_003058"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416012.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0031729.1"
                     /translation="MSSVNFEDLKNKFINSDLDEKIRIYTTTEGLSVEQFKELLKYYP
                     IQHLSKLEKALG"
     gene            complement(635..856)
                     /locus_tag="KR257_003059"
     CDS             complement(635..856)
                     /locus_tag="KR257_003059"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000002841.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha/beta-type small acid-soluble spore
                     protein"
                     /protein_id="HBH0031730.1"
                     /translation="MASNNNNNRTVVPGAKEALNQMKLEIANELGMSNYQQVDKGNLT
                     ARENGYVGGYMTKKLVEMAEQQMAGKSNR"
     gene            complement(940..2166)
                     /locus_tag="KR257_003060"
     CDS             complement(940..2166)
                     /locus_tag="KR257_003060"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003427089.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NAD(P)/FAD-dependent oxidoreductase"
                     /protein_id="HBH0031731.1"
                     /translation="MKKVVIIGGGPAGMIAASTACEKGYDVTLIEKNHKLGKKLAITG
                     KGRCNITNACEIEELIENVPTNGKFLYSAFYTFTNDDVISMFNNLGVKTKTERGKRVF
                     PESDKAFDIVNALERQLKSKKVNILLNSKVEKIISKNNKIEKVILNDKKEIKCDSVVV
                     ATGGLSYPLTGSTGDGYKFAISQGHTIIDTKPSLIGIEVQESFTKDLEKLSLRNVEIR
                     VFNSKQKKVYSDFGELEFTKFGLDGPIIKSASCRMKDTRKENYTILLDLKPALDEEKL
                     DKRVQKDFQKYTNKKFEKALDDLLPKKLIPIIINLSEINPNTVVHQISREQRKNLVHL
                     LKNLKFTVKRYRPIEEAIITSGGVKVNEINSSTMESKLVEGLFFAGEVIDIDAYTGGF
                     NLQIAFSTGYLAGFNC"
     gene            complement(2228..3160)
                     /locus_tag="KR257_003061"
     CDS             complement(2228..3160)
                     /locus_tag="KR257_003061"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897871.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphatase PAP2 family protein"
                     /protein_id="HBH0031732.1"
                     /translation="MDIQLNILLFFQNLRNPILNFIFLVFTISTEAPLLILITTIIYW
                     CINKKCGQKILFAIIGNFVVNLGIKEFVKAPRPIGIKGLESLRVSTAGGYSFPSAHTQ
                     TATTFWVSIMTIFKKRYLHLIGAVMVLGVGLSRLYLAVHWPIDVIAGWILGIFFTVVF
                     VKIFDYIDDNKNYILLVVLLIPFIIVAIFLNSPEYFEKFGIIVGFVFGYMVEDRFVKF
                     NTDNNNKKINFSNKNKGSKNIIFSRICRFLVGIVTIGMLYIGIKLFISMLIVTLNISD
                     STMSIIFMNFIKNTVVVFYGIAGAPALFKLLKLN"
     gene            complement(3249..3776)
                     /gene="hpt"
                     /locus_tag="KR257_003062"
     CDS             complement(3249..3776)
                     /gene="hpt"
                     /locus_tag="KR257_003062"
                     /EC_number="2.4.2.8"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416006.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypoxanthine phosphoribosyltransferase"
                     /protein_id="HBH0031733.1"
                     /translation="MYKVTGKMLTEEQIKEKVYELGKKIEEDFKGEDLLVVGILKGAS
                     VFVSDLIRCIDLDVNIDFMSVTSYGNSTESSGTVKILKDLDVDIEGKNVLIVEDIIDS
                     GLTLSNLVAALKTRNPKSLKLCTLLDKPQRRKANIPVDYVGFVIEDKFIVGYGIDYAE
                     KYRNLPYIGIVEDVE"
     gene            4005..5093
                     /locus_tag="KR257_003063"
     CDS             4005..5093
                     /locus_tag="KR257_003063"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011010417.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aminotransferase class I/II-fold pyridoxal
                     phosphate-dependent enzyme"
                     /protein_id="HBH0031734.1"
                     /translation="MSTNHGANLYSLSSKYGFSKEEFMDFSSNINPFGTSSLAKQYIV
                     NNIDMVSMYPDPDYIDLKTSISNYCKCSIDNIVLGSGATELISSFIHTINPKQALLLS
                     PAYSEYEKELSKINCSIEKYFAKEEDNFHINLENLIKTINAKDYDLVVICNPSNPTGF
                     AFTKVEVREILKNTDSFLMIDETYVEFTDTDTYSCTQLVDDYSNLFVIRGTSKFFSTP
                     GIRLGYGLISNTNVKNEINKNLDLWNINIIASKMGEIMFSDLDFISNTISLMNTERDY
                     LLKELKNIKSLDIYNTKGNFILCKIKTKELTAKSLREQLLPQKIIIRDCCSFEGLDEY
                     FFRVCILKPNENKLLISSLKAIFILKTY"
     gene            complement(5256..6446)
                     /locus_tag="KR257_003064"
     CDS             complement(5256..6446)
                     /locus_tag="KR257_003064"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009271880.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="site-specific integrase"
                     /protein_id="HBH0031735.1"
                     /translation="MSNVKRKDSKNRNLRNGESQRKDGRYVYKYTDIYGKPQFIYSWK
                     LVPTDKTPAGKRDDISLREKEAQIKKDLNDGIDTVGGKMTVCQLYDKKNSQRKNIKRA
                     TEKGRQYLMNALKNDPLGMRAIDTVKQSDAKEWAIRMSEKGYAYKTIDNYKRSLKASF
                     YMAIQDDCIRKNPFEFKLSDVLEDDTEQKVILTPEQEGRLLAFMEKDKIYSKYYDEVV
                     LLLETGLRISEFCGLTTHIDMQNRILNIDHQLLKDSEMGYYIETPKTKNGKRELPLTE
                     RAYQAIQRILKNRGKAQPLIVGGYSNFLFLNREGLPKVAGNYEGMVRGLIKKYNKYHT
                     DKLPNITPHSFRHTYCTNMANRGMNPNTLQYLMGHANITMTLGYYAHGTFQSAKAELE
                     RLAC"
     gene            complement(6524..6727)
                     /locus_tag="KR257_003065"
     CDS             complement(6524..6727)
                     /locus_tag="KR257_003065"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002262306.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="excisionase"
                     /protein_id="HBH0031736.1"
                     /translation="MNNTDVPIWEKYTLTIEEASKYFRIGEKKLRKLAEENLDAGWVI
                     VNGNRIQIKRKQFEKIIDTLDEI"
     gene            complement(7041..7274)
                     /locus_tag="KR257_003066"
     CDS             complement(7041..7274)
                     /locus_tag="KR257_003066"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003431885.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="HBH0031737.1"
                     /translation="MPKELTPTFTVISKACDGDETAISKILEFYDPYINRCCMRPFYD
                     DNNNLRLAVDLEMKGFIKEAIIRKILNFDIKRF"
     gene            complement(7259..7699)
                     /locus_tag="KR257_003067"
     CDS             complement(7259..7699)
                     /locus_tag="KR257_003067"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003431889.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0031738.1"
                     /translation="MKPSELQEKTCHQFDCAIKTVIRHRAIDFYRAIRRSEKKEMPFA
                     EIMDDLLNSIGTEDTYSTDYVAVFEVCGEKVSIEDEQLARALKAIEERKRNIVLQYFF
                     IGDTDTYIGKMLDCSRANVTKCRIQALDKLKQLIEEEKEKCQKS"
     gene            complement(7974..8609)
                     /locus_tag="KR257_003068"
     CDS             complement(7974..8609)
                     /locus_tag="KR257_003068"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009905051.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBH0031739.1"
                     /translation="MLEVKNVSYAYKTKKDKTILNNVSATFEEGIFYTIVGPSGAGKT
                     TLLSLLAGLDTAVKGTVLCNGEDITKKGLNYHRKHNISLVFQNYNLIDYLTTVENVKL
                     GGSGNAEKLLEEVGIGKEYWQRNVLQLSGGQQQRVAIARALASDAHVLLADEPTGNLD
                     ETTADEIIALLKKTAHELGKCVVVVTHSKHLAEEADEILEIKNGAISFLSD"
     gene            complement(8623..10068)
                     /locus_tag="KR257_003069"
     CDS             complement(8623..10068)
                     /locus_tag="KR257_003069"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005342380.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBH0031740.1"
                     /translation="MNFFGLARRSVFRKPIKSILLLLIVFAISTLLLAGVASKNASIE
                     VQDKTRQAIGAGFLLERNAEYRTKRVREYSEKIGNDKEGSFGGYHQEKEIINGVETWS
                     GWTTNEFESLDIKDIEKLAKTKGIADYNITTATTPVNPVNFKRIEDKDVDQSVDEGGV
                     SLIGNKDMKLDRNVLSGNLHIKEGRMITPEDKDMCVISEELAKQNNLKIGDKISFNDY
                     HDTVNSKVSEAEIVGIYQVDQKMSPLMQGDTYRSENVIFTDLRFPEKAEGETSPLYER
                     AYFKVEDVEAYDEVKENLQKVDINWEQYDLIDNNGNSETMSSNFNDLAKVSEMMILVI
                     SVASFVILVLVFLFWLKNRVQEVGIFLSLGVPKFRIIGQIWSEAIMIAVLSLMLSFAV
                     APAVSKVTANYLVSQQVQQMQEEEKNNEGKVSTEYVAPKQDVQNISVEVTPEMYLLDG
                     VSVLVLITASVLVSGIVILKRNPKDILSEMS"
     gene            complement(10072..11295)
                     /locus_tag="KR257_003070"
     CDS             complement(10072..11295)
                     /locus_tag="KR257_003070"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003431894.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBH0031741.1"
                     /translation="MKFYQLGFRYLQRKKGKTILLLIVLILVNSMILGTSMILRTTNE
                     SKQAMQEKTNSKIVAEITSKDSKITENEVNKIETLEDVSSINRIGRQEVFPNDFAPVT
                     LNTSTNEENLKIALLSYDDLEKDSPFSEMQYRLSSGDYIKHEKKGAVINANLANQNEL
                     KVGDTIELSTENGTKVSVQIIGIFMSAGNVEKDQPTETTAVNRIENQVFIDNSTYKEL
                     FKEAEFEKLCVYSKRPEKLDVLETSLQKIFGNDVELSTSDTLYQQMSAPLEQISKVAN
                     LMLVLTLVTGTVVVSLLLCMWMRTRQKEVAIFMSLGKTKSEIFLQTLLEAGSVFTLSV
                     LGATAIGKLFSGVLQNVITGSETVTENLKVVLQIQDIGMLFLLGGAVILVALCCSILP
                     ILRANPKDILAKMEG"
     gene            complement(11307..11804)
                     /locus_tag="KR257_003071"
     CDS             complement(11307..11804)
                     /locus_tag="KR257_003071"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003431895.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="chitinase"
                     /protein_id="HBH0031742.1"
                     /translation="MKKTNISKFVAVGLCICALTGCGASPDEKPDTSNPIVNSNTNEE
                     NANGSSENKGNDILESANLIGSVLEFTDNGCSVSQAKETEGGASLQIEASGLENKDNA
                     VSVTYNPDCEFFVATLNKQLGSVTNITTGSISDVKKQSNVYLYGEFSDTLHFNATKVV
                     IARWE"
     gene            11967..12653
                     /locus_tag="KR257_003072"
     CDS             11967..12653
                     /locus_tag="KR257_003072"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005342376.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HBH0031743.1"
                     /translation="MKILLLEDDLELCKNIKISLEKENYMVDCCNDGETAMLYALNTD
                     YAYDLAIVDRMLPIIDGLTIIKSMRRKGISIPILIITAMSTLDNRVEGLDGGADDYLV
                     KPFHIKELLARVRALTRRPANIQLSSKLEYGDLTFDKDSRTLSTPVNSLLLTSKETEL
                     TFVFMQNPETLFSREQLILKIWGSSSEVETGNVDSYISFLRKRLKELKSSCKITTVYG
                     AGYKLEKETC"
     gene            12647..13939
                     /locus_tag="KR257_003073"
     CDS             12647..13939
                     /locus_tag="KR257_003073"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003431899.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HAMP domain-containing histidine kinase"
                     /protein_id="HBH0031744.1"
                     /translation="MLNNLYRKLHILFASSVMLIITLVISFVVANTVHTEKINESTLF
                     QRLTTLLIYQVESASSDMDKALKTYEESYHIFSLITDTRGNTIYQSDFPFPTSADNLL
                     HDVEKQISTQPLSQIENSTTSQGGFLEIRGTHHDTYFVIPATIRTANDTVYHATFLYQ
                     TASLTDILQKTLPIYLLIWFLACIVVIVLTRYLLKKSFAPTERILQSQKDFVATASHE
                     LKSPLAVMISNTDMLLDNVSLNEQAKQAVQTIDFECMRLSRLVKDMLLLASSDAKTWT
                     LHKSTINVDTLLITLYETYEPVCMKQNLELKLHLSEESYPAMFTDKDRLFQILCVFMD
                     NAIQHSKNNSLIEIEVIATEKNIAFSVVDHGQGISDEDKQYIFDRFYSGDKSHTNKSN
                     FGLGLSIAKELTQMLNGIIIINDTAGGGATFTVKFPLK"
     gene            complement(13985..14209)
                     /locus_tag="KR257_003074"
     CDS             complement(13985..14209)
                     /locus_tag="KR257_003074"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008393106.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0031745.1"
                     /translation="MIGLKKRDIKKALKAGAKAGGVSLADVRADIEATIDEAMNSTAP
                     EVQANFKKYFGNKRPTPEEYIYKITKKTKI"
     gene            complement(14255..14950)
                     /locus_tag="KR257_003075"
     CDS             complement(14255..14950)
                     /locus_tag="KR257_003075"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016179626.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="conjugal transfer protein"
                     /protein_id="HBH0031746.1"
                     /translation="MCTRFVYNGIDKIVGFNFDIDLSVWDHTVITEENRFYIGIKMPD
                     GLYHSFHGINKNGNVGTLLYVHGNENARYIESEDCITISELTEKFIKAEISFDKALDI
                     VKKKKIIYAPDATMQAMLSDKKGRVLIIEPGIGYRYEQENFSLITNYSILKPDITKPY
                     IVSGDTRYEVAKELLAGYDKDFSVNDAFKVLKSVSQKDLWATRVSFVYSTEKNKVYYV
                     LNNDFSNVFEFQF"
     gene            15128..15685
                     /locus_tag="KR257_003076"
     CDS             15128..15685
                     /locus_tag="KR257_003076"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005946872.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="HBH0031747.1"
                     /translation="MKTTKEAVIKATSDLADEKGLNNVSLKAVAQKLNIRTPSLYNHI
                     ESLDNLLLEVAHNGMRDMNERMMKIAVGKIGKEAIKLVSIEYLNYMIEHPGVYETIQW
                     AVWHGTEETATIFNNYLSLLTTLIQSCSLNKDKTLEILNMLTGIIHGYTTLQLGNAFS
                     ASDKVRFELAEAIDTLLVGIFQKYK"
     gene            complement(15732..16643)
                     /locus_tag="KR257_003077"
     CDS             complement(15732..16643)
                     /locus_tag="KR257_003077"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860758.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="conjugal transfer protein"
                     /protein_id="HBH0031748.1"
                     /translation="MFKKNKKQTETVKEPKEKKVRTVKVGTHKKTMIALWVVLIASVS
                     FGVYKNFTAIDQHTTHEKEIIELRLQDTNGIENFVKNFAKSYYTWSNSKEAIEARTQA
                     ISGYLTKELQDLNVDTIRTDIPTSSTVTDVIVWHIEQSGTDTFSATYEVDQQIKEGEQ
                     TSNVKATYTVKVHVDADGDMVIIQNPTLAPAIEKSDYEPKTPEADASVDADTVNDATA
                     FLETFFKLYPTATEKELAYYVSGNVIEPIGRDYLYSELVNPIFTKNGDNVKVKVAVKF
                     LDNQTKATQVSQYELVLHKDSNWKIVG"
     gene            complement(16659..>16763)
                     /locus_tag="KR257_003078"
     CDS             complement(16659..>16763)
                     /locus_tag="KR257_003078"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018368130.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptidase P60"
                     /protein_id="HBH0031749.1"
                     /translation="GNNQMYHAGDPIGYADLSSSYWQQHLIGAGRVKQ"
BASE COUNT         5060 a         3248 c         2453 g         6002 t
ORIGIN      
        1 aaatgtttca atatctctca aataacccaa ttaaaaaact tactaagtaa tactggttat
       61 aatttattaa ttccatataa atacttaact gctagagata tagaaggaat agttactctt
      121 attaatactg ggtctattga acttggaaat gagagaatct ataattatat atcaaaagca
      181 taataattta aacctattat aaaaaggcaa tttatttaat aaaaaatatt tttaatatta
      241 aataaattgc ctttttaatt ttggattaaa tactgctatc caagtgcttt ttctagttta
      301 gataaatgtt gtattggata atattttagt agctctttaa attgttctac tgataaacct
      361 tctgttgttg tatatattct tattttttca tctaagtcac tattaataaa tttgtttttt
      421 aaatcctcaa aatttacact actcatttta catcactcct tatgtaacat attcatttgt
      481 attattttat ccaaatacat aaaatttatt acataaaaat atatctattt aataatttaa
      541 taaaaaaaag ctatctcaat ttagaaatta ctttctatat ttgagatagc tctagctaaa
      601 ctaatagcca atagttataa ataattattt ataactatct gttgcttttt ccagccattt
      661 gttgttcagc catttcaact aattttttag tcatgtatcc acctacataa ccattttctc
      721 ttgcagtaag gtttccttta tcaacttgtt gataattact cataccaagt tcattagcta
      781 tttctaattt catttggttt aaagcctctt ttgctcctgg tactactgtt ctgttgttgt
      841 tattgttact tgccatgttg attaccttcc ttctgtttaa tttattttgt gttgctgata
      901 atattatgtg attttaaaca tttttaattc aggtaatttt tagcaattaa aacctgccaa
      961 atatccagta gaaaaagcta tttgcaaatt gaatccacct gtatatgcat ctatatctat
     1021 tacttctcca gcaaaaaata aaccttctac taattttgat tccattgtac ttgaatttat
     1081 ttcgtttact tttacaccac cagaagttat tatagcttct tcaataggtc tgtatctctt
     1141 tactgtaaac tttaaatttt ttaataaatg gactaagttt tttctctgct ctctagaaat
     1201 ttggtgaaca accgtatttg gattaatttc acttaagttt attattatag gtattagttt
     1261 ttttggaagt aaatcatcta atgctttttc aaatttttta tttgtatact tctgaaaatc
     1321 tttttgaact cttttatcca atttttcctc atctaatgca ggttttaaat ctaataatat
     1381 agtgtaattt tctttccttg tatctttcat tctacaactt gcagacttga ttataggtcc
     1441 atctaaacca aatttagtaa attcaagttc tccaaaatca ctataaactt tcttttgttt
     1501 gctattaaac acccttattt caacatttct caatgataat ttttctaaat cttttgtaaa
     1561 actttcttgt acttctatac caattaaaga tggttttgta tctataattg tgtgcccctg
     1621 tgaaattgca aatttatatc catcaccagt agaaccagta agtggataac ttaatccacc
     1681 agttgctact acaactgaat cacacttaat ttctttttta tcgtttaaaa ttactttttc
     1741 aattttatta tttttagata ttattttttc tactttcgaa tttaataata tatttacttt
     1801 cttactttta agttgtcttt caagagcatt tacaatatca aatgctttat cactctctgg
     1861 aaaaaccctt tttcctcttt ctgttttagt ctttactcca agattattaa acatacttat
     1921 tacatcatca tttgtaaaag tataaaaagc actataaaga aattttccat ttgtaggtac
     1981 attttctatt aattcctcta tttcacaagc gttagtaata ttacatctac cttttcctgt
     2041 tattgcaagt ttttttccta atttatgatt tttctcaatt aatgttacat catagccttt
     2101 ctcacatgca gttgatgcgg ctatcatccc tgctggtcca ccacctatta ttactacctt
     2161 cttcaaataa tcactctttt ctacccttaa tttttttaat ttaaactatt gactctatac
     2221 cttaaaatca atttaatttt aaaagtttaa ataatgctgg agctcctgct attccataaa
     2281 aaacaactac tgtattctta ataaaattca taaaaattat actcatagta gagtcactta
     2341 tatttaaagt gactattaac attgaaataa acaacttaat gccaatatat aacattccta
     2401 ttgttactat cccaaccaaa aacctacata ttcttgaaaa aattatattt ttactcccct
     2461 tatttttatt actaaaattt atttttttgt tattattatc tgtattaaat ttaacaaatc
     2521 tatcctcaac catatatcca aatacaaatc ctactattat accaaatttt tcaaaatatt
     2581 cagggctatt tagaaatata gccactatta taaatggtat aagtaaaact acaagtaaaa
     2641 tataattttt attatcatca atatagtcaa atatttttac aaatacaact gtaaaaaata
     2701 ttcctaatat ccaacccgct atcacatcta ttggccaatg aacagctaaa tacagcctag
     2761 acaatcctac tcctaaaacc ataactgcac ctattaaatg aagatatctc tttttaaata
     2821 tagtcataat actaacccaa aatgttgttg cagtttgagt atgagcactt ggaaaagaat
     2881 aaccaccagc agtagaaact ctcaatgatt caagaccttt tattcctatt ggtctgggag
     2941 cttttacaaa ctctttgatg cctaaattta caacaaaatt tccaattata gcaaacagta
     3001 ttttctgtcc acatttttta tttatacacc agtatataat tgttgtaatt aatattaata
     3061 acggtgcttc tgtgcttatt gtaaagacaa gaaatataaa gttcaaaatt ggatttctta
     3121 aattttggaa aaataataat atatttaact gaatatccat atagatgtct cctttactaa
     3181 aattttatat aattaactaa aaagcactaa ctcccttaga aattagtgct tttgattcac
     3241 atttaaatct attctacatc ctcaactata cctatataag gtaaatttct atacttttca
     3301 gcatagtcta ttccataacc aacaataaat ttgtcttcta taacaaatcc aacatagtct
     3361 acaggtatat tagcttttct tctctgaggt ttgtcaagta gagtacatag ttttaaagat
     3421 tttggatttc tagtttttaa agctgcaact agattactta atgttaaacc agaatctatt
     3481 atatcctcta caatcaacac attctttcct tcaatatcta catctaaatc ttttaatatt
     3541 ttaactgttc cagaagactc tgttgagttt ccataacttg taacactcat aaaatctata
     3601 tttacatcca aatctataca tcttattaaa tctgaaacaa atacactagc tcctttaagt
     3661 atacctacca ctagtaaatc ttcgccttta aagtcttctt ctatcttttt tcctaattca
     3721 taaacttttt cttttatttg ttcttctgtc aacatttttc ctgtaacttt gtacattttg
     3781 tatcctcccg ctttccttct attaacttat atattatagc ataccaaaat atcaattaaa
     3841 atctttttca tcatttttaa acctaaatta acagcttatc catacttttt tgctttttcc
     3901 attaaaaatt tggaataacg attcctttgt attataatct atatgtacat atattaatca
     3961 gttattttta tcgattatat aattttattt ttggaggtac ttttatgagc acaaaccatg
     4021 gagctaattt atatagttta tctagtaagt atggcttttc aaaggaagaa tttatggatt
     4081 ttagctcaaa tataaatcct tttggtacat caagtttagc caaacaatac attgtaaaca
     4141 atatagatat ggtatctatg tatcctgacc ctgattacat agacttaaaa acttctatat
     4201 ccaattactg caaatgttct atagataata tagtacttgg cagtggagct acagaactaa
     4261 tttcatcatt tatacataca attaacccta aacaggctct tttactctct ccagcctatt
     4321 cagagtatga aaaagagtta tctaaaatta attgttctat agaaaaatac tttgcaaaag
     4381 aagaagataa ttttcatata aatttagaaa atcttataaa aactatcaat gctaaagatt
     4441 atgatttggt agtaatctgt aatcctagta atccaactgg atttgcattt actaaagtag
     4501 aagtgagaga aattttaaaa aatacagact catttttaat gattgatgag acttatgtag
     4561 agtttactga tacagataca tactcttgta ctcaattagt tgatgattat tctaatttat
     4621 tcgttataag aggtacatca aaattttttt caacgcctgg aataaggctt ggatatggtc
     4681 ttatatctaa cactaatgtc aaaaatgaaa taaataaaaa tctagattta tggaatataa
     4741 acataatagc ttctaaaatg ggtgaaatca tgtttagtga tttagatttt atatcaaata
     4801 ctatttcctt aatgaacact gaaagagatt acctgcttaa agagcttaag aatataaaaa
     4861 gcttagatat atacaatact aaaggcaatt tcatattgtg taaaatcaag acaaaggaat
     4921 tgactgctaa atctcttcga gaacaattgc ttccacaaaa aataataata agagattgtt
     4981 gttcatttga aggtctagat gagtatttct ttagagtatg tatattaaaa cctaatgaaa
     5041 ataaattatt aatatcatct cttaaagcaa tttttatttt aaaaacttac taaatttctg
     5101 attatctttt cataagttgg taaatgccga tatatcccgt attttagggc tttatcggta
     5161 ttttcttttt ggaagatacc ttgcataagc tggcatttac cagcatgaaa atgcaaccaa
     5221 aagtagtaaa tgagtagtaa atataagctc cgatattaac aagccagtct ttccagttct
     5281 gcttttgcag attgaaatgt gccgtgtgcg taatagccaa gtgtcatggt tatgttagcg
     5341 tgtcccatga gatattgcag agtatttggg ttcattcctc tgtttgccat attcgtacaa
     5401 taagtatgtc ggaatgaatg tggcgtgatg ttcggtagct tgtccgtgtg atacttgtta
     5461 tacttcttaa tcagccctcg caccatgccc tcatagtttc ctgcaacttt aggcaaaccc
     5521 tcacggttta agaataggaa attgctgtaa ccacctacaa tcagcggttg tgcctttcct
     5581 ctgttcttta gtattctttg gattgcttga taagcccgtt ctgtcaatgg aagttcccgt
     5641 tttccgtttt tggtctttgg cgtttcaata tagtagccca tttcgctatc tttcaataac
     5701 tggtggtcta tattgagtat tctgttctgc atatcaatat gcgtcgtcag tccgcaaaat
     5761 tcagaaatac gaagtcccgt ttccagcaga agcacaacct catcataata cttactgtaa
     5821 atcttgtcct tttccataaa ggcaagcagg cgtccttcct gctctggtgt aaggataact
     5881 ttctgttcgg tatcatcttc cagaacatca cttaacttaa attcaaatgg gttctttctg
     5941 atacagtcgt cttgtatcgc catgtaaaat gacgctttca aggaacgctt atagttatca
     6001 atcgttttat aggcatatcc tttttcgctc attctgatag cccattcttt agcgtccgac
     6061 tgcttaaccg tatcaatcgc cctcataccc aatgggtcat ttttcagagc gttcataaga
     6121 tactgtcgtc ctttttcagt agcccttttg atgttctttc tttggctgtt cttcttgtcg
     6181 tagagctggc agactgtcat tttaccgccg actgtgtcga taccgtcgtt aaggtctttt
     6241 tttatctgtg cttctttttc cctcaacgat atatcatcac gctttccagc aggtgtcttg
     6301 tctgtcggta caagtttcca agaatagata aattgtggct ttccgtatat atcggtatat
     6361 ttataaacgt atcttccgtc ttttcgctgg ctctctccat tacgcaaatt gcgattttta
     6421 ctgtcttttc gtttcacatt agacatagtg taaagctcct ttccgtcatg gaatgagccg
     6481 tgatacgcta ctaatattat accatatcta cggctcaatg acattagatt tcgtccaatg
     6541 tatctatgat tttttcaaat tgttttcgct taatctgaat acgattacca ttcacgataa
     6601 cccagccagc gtcaagattt tcttcggcta atttacgcaa tttcttttcg ccaatgcgga
     6661 agtatttgga cgcttcttca atcgtcagcg tatatttttc ccagataggc acatcagtat
     6721 tgttcataat ctatgcaccc cctttactgt gtgtcatttt ttacaagcag gcagacggct
     6781 ttggaaagct ccgttagtat ctcaactatt cccattcctg tgggcagaac cgcaccatgc
     6841 ggacgtatca ttattctgtg aggataggtc gtggcaaagc gacttttcca acggtcgctc
     6901 tcggatcact gcgtgggtcg ctcgctttct tttgaaaagg tcgtggcgta cagtccccgt
     6961 ggcttgctat ctcacaaacg tatctgtctg ctttattcag ttgtcaaaga ccagacgggc
     7021 ataatcaatc ccgatatgaa ttagaagcgt ttaatatcaa agtttaagat tttacgaata
     7081 atcgcttctt tgataaaacc tttcatttcc aaatctaccg caagacgtaa gttgttgtta
     7141 tcgtcgtaaa atggacgcat acagcaccga ttgatatatg ggtcataaaa ttccaagatt
     7201 tttgaaattg ctgtttcgtc gccgtcgcag gctttggaaa taaccgtgaa agtcggtgtc
     7261 agctcttttg gcatttttct ttttcctcct caatcagttg ctttaacttg tctagtgctt
     7321 gtattctgca cttcgttaca ttcgctctgg aacagtcaag cattttccca atgtaagtgt
     7381 ccgtgtcccc aatgaaaaaa tactgtaaaa cgatattacg ctttcgttct tcaatagctt
     7441 tcaatgcacg agccagttgt tcatcttcga ttgatacttt ttctccacag acttcaaata
     7501 ccgcaacata atccgtagaa tatgtatctt ctgtacctat ggaatttaag aggtcgtcca
     7561 taatttcggc gaatggcatt tcttttttct ctgaacgacg tatcgctcga tagaagtcaa
     7621 tcgctctatg acgtataact gttttaatag cacaatcgaa ttgatgacag gttttttctt
     7681 gtagttctga cggtttcatt ttcctcacct cctttcgcta gtcgaaaaga ggtgtctgcc
     7741 ccttttcata tataccgcgt tgaaagtggg ggacagcgta accaaaatcg aaaaaacttt
     7801 aaaaaatttt tttctggcat gaaaaaagcc cgcacaaaac atatagtctg tacgagcttt
     7861 taaaactgtg ctatattcag ttgttataaa aatgccgtta ggttcaaact gattgcgtcg
     7921 aggtatatct aaaatattcc ataatgacaa ctcctttacg gcactattct aatttaatca
     7981 gacagaaaag aaattgcacc gtttttaatt tctaagattt cgtcggcttc ttctgccaaa
     8041 tgcttactgt gtgtaaccac aacaacacat tttcctaatt catgtgcagt ctttttcagc
     8101 aaagcaatga tttcatcagc ggtagtttcg tcaagatttc ccgtcggttc gtctgccaaa
     8161 agtacatgag cgtcgctggc taatgctctt gcaatcgcta cacgctgttg ctgtccgcca
     8221 gatagttgca atacatttct ctgccagtat tcttttccaa tgccgacttc ttccaataat
     8281 ttttcagcat ttccactacc acctaatttg acattttcaa ccgttgtcaa ataatcaatc
     8341 agattataat tttgaaatac caatgagata ttatgctttc tgtggtaatt cagccccttt
     8401 tttgtaatgt cctcgccatt gcaaaggaca gtccctttta ctgctgtgtc caagcctgct
     8461 aacaaggata agagtgttgt ttttcctgca ccactcggac cgacaatggt ataaaagata
     8521 ccctcctcaa aagtagctga tacgttattc aaaatggttt tatctttttt ggttttgtaa
     8581 gcatagctta cattctttac ttctaacatt ttcgtcgtcc tcctaactca tttccgataa
     8641 aatatctttc gggtttctct ttagtattac aattccagat accagaacag aagccgttat
     8701 caacacaaga acacttacac cgtccaacag atacatttct ggcgtaacct ctacgctgat
     8761 attctgcacg tcctgctttg gtgcaacata ttctgtggat acttttccct cgttattttt
     8821 ttcttcttcc tgcatttgct gaacctgctg tgataccaga taatttgcag ttactttgga
     8881 aacggcagga gcgacagcaa aggatagcat aagggaaaga acagcaatca taatcgcttc
     8941 actccaaatc tgcccgataa ttctgaattt cggaacaccg agagataaga aaatgccgac
     9001 ttcctgcact cgatttttca gccagaaaag aaatactaaa acaaggataa caaaacttgc
     9061 aacagagatt accaatatca tcatttcgct tacttttgct aaatcattga agtttgagga
     9121 catggtttcg gaatttccgt tattgtcaat caaatcatat tgctcccagt tgatgtctac
     9181 tttttgcaga ttttctttta cttcgtcgta agcttccaca tcttctactt tgaaataggc
     9241 tctttcatat aatggacttg tttcaccctc tgccttttct ggaaatctca aatctgtaaa
     9301 tattacattt tccgaacggt aagtatctcc ctgcataagt ggggacatct tttgatccac
     9361 ttgataaatt ccaacaatct cagcttctga tacctttgaa tttacagtat cgtggtaatc
     9421 attaaaagaa atcttatcgc cgattttcag attattttgc tttgcaagtt cctctgaaat
     9481 gacacacata tctttatcct ctggggttat cattcgtccc tctttgatat gcaggtttcc
     9541 agataaaaca tttctgtcaa gtttcatatc tttgtttcca attaagctta cacctccctc
     9601 atctacactt tggtctacat ctttatcttc aattcttttg aaatttacag ggtttacagg
     9661 agttgttgct gttgtaatat tgtaatcagc aattcctttt gtttttgcca gtttctcaat
     9721 gtcttttata tctaagcttt caaattcatt tgttgtccag cctgaccaag tctccacacc
     9781 attgataatc tctttttcct gatggtagcc accaaaacta ccttccttat cattaccaat
     9841 cttttctgag tattcacgaa ctcgttttgt tcggtactct gcatttcttt ctaaaagaaa
     9901 gcctgcacct atggcttgtc tggttttgtc ctgcacctca atactggcat ttttgctcgc
     9961 cacacctgca agaagcaggg tactgattgc aaaaacaatc aacaataaga gaatactttt
    10021 tatgggcttt ctgaacacag aacgccttgc caatccaaaa aaattcatgt actatccctc
    10081 cattttcgct aatatatctt ttgggtttgc tcgtaatatc ggaagaatgg aacagcacaa
    10141 tgccaccaga ataactgcac cacctaaaag gaacaacatt ccaatatctt gtatctgcaa
    10201 caccactttc agattttctg ttactgtttc tgaaccagta atgacatttt gcaaaacgcc
    10261 cgagaacaat ttaccaatgg ctgttgctcc taaaaccgaa agtgtaaata cactgcctgc
    10321 ttctaataaa gtttgcagga aaatttcact ttttgtcttg ccgaggctca taaagattgc
    10381 cacctctttt tgccttgtcc gcatccacat acataacagc agggaaacaa caacagtacc
    10441 agttaccaat gtaagtacca gcataagatt tgccacctta ctgatttgct ctaatggagc
    10501 agacatctgt tgataaaggg tatcggaagt gctaagttct acatcatttc cgaatatttt
    10561 ttgcaagctg gtttccagca catctaattt ttctggtctt tttgaataaa cgcagagttt
    10621 ttcaaattca gcttctttga acaattcttt ataagtgctg ttgtcaataa agacttgatt
    10681 ttctattcga ttgactgcgg tagtttctgt tggctggtct ttttccacat ttcctgcgga
    10741 catgaaaatt ccaataattt gaacagatac ttttgttccg ttttctgtac ttaattcaat
    10801 cgtatctcca acttttagct cattttgatt tgcaaggttc gcattgataa cagcaccttt
    10861 tttctcgtgt ttgatataat cgccagaaga taagcggtac tgcatttctg aaaaagggct
    10921 gtccttttcc aaatcatcat aggagagcaa cgctattttc aaattttcct cattcgtaga
    10981 agtattgagc gtaacgggag caaaatcatt cggaaatacc tcttgtctgc cgatacggtt
    11041 gatagacgaa acatcttcca gcgtttcaat cttgtttact tcattctctg ttatcttgct
    11101 gtccttactt gtaatttcag ccacaatctt agagtttgtc ttttcctgca tggcttgttt
    11161 ggactcattt gtagtcctta aaatcatgct tgtacctaaa atcatactgt ttacaagtat
    11221 caaaacaatc aacagaagaa tggtttttcc tttttttcgc tgtaaatagc gaaaaccaag
    11281 ttgataaaac ttcatacttc acacctctat tcccaacggg ctatgacaac ctttgttgca
    11341 ttgaaatgaa gtgtgtctga aaattctcca tagagatata catttgattg tttctttaca
    11401 tcggatatag accccgttgt tatattcgta acagaaccca actgtttatt tagtgtcgca
    11461 acaaaaaatt cacaatctgg gttataggtt acagaaacag cattgtcttt attttccaat
    11521 cccgacgctt cgatttgcag gctagctcca ccctcagttt cttttgcttg acttacggaa
    11581 caaccattgt ctgtaaattc caaaacactt cctatcaaat tagcagactc taatatgtcg
    11641 tttcctttat tttctgaaga accatttgca ttttcttcat tcgtattaga attgacaata
    11701 ggattagacg tatctggttt ctcatctgga cttgcaccac accccgtcaa tgcacagata
    11761 cataatccaa ctgctacaaa tttactgatg tttgtttttt tcatttttgt attccacctt
    11821 tcttgttcga tatgccccta ttgtaaaagc aaaccattct aaaaatcctg taaaaaagta
    11881 agaaaatcat catcattttt tagaggattt ttacagactt ttctgttata ctgtctataa
    11941 tttatataga aaaggattga tacattatga aaatacttct tctggaagat gatttagagt
    12001 tatgtaaaaa tataaaaatt tctctcgaaa aagaaaacta tatggttgat tgttgcaatg
    12061 acggggaaac cgctatgctg tacgctttaa atacagacta tgcttatgac ctcgccattg
    12121 tagaccgtat gctaccgatt attgacggct taacaatcat aaaatctatg cgtagaaaag
    12181 gaatatctat tcctatcctt atcattactg ccatgagtac ccttgacaat cgggtggagg
    12241 gtttagacgg cggtgctgat gattacttag taaagccatt tcatatcaaa gaattgcttg
    12301 caagagttcg ggcattaaca agacgccctg ccaatatcca gttatcttcc aaattagaat
    12361 atggagattt aactttcgat aaagacagcc gaaccttatc tacacccgtc aattctcttt
    12421 tattaacttc aaaagaaacc gagttgactt ttgtatttat gcagaaccca gaaacactat
    12481 tttcccgtga acagctaatc cttaaaatct ggggcagttc ttccgaggta gaaactggca
    12541 atgtagacag ttacatttct tttctgcgaa aacgcctaaa agaattaaaa agttcctgta
    12601 aaataacaac ggtctacggt gcagggtaca aactggagaa agaaacatgt taaataactt
    12661 ataccgaaaa cttcatattc tgtttgcaag ttctgttatg ctgattatta cccttgtgat
    12721 ttcctttgtc gttgcgaaca cagttcatac agagaaaatc aacgaaagca ccttatttca
    12781 gagattgaca accttgctga tttatcaagt ggaaagtgct tcttcggata tggacaaagc
    12841 actcaaaacc tacgaagaga gttatcatat tttttcttta attactgata caagggggaa
    12901 taccatttat cagagtgatt tcccatttcc aacttctgcg gacaatctgt tgcatgatgt
    12961 agaaaagcag atttctacac aaccattatc acaaatagaa aacagcacaa cttcacaagg
    13021 cggttttctg gaaataagag gaacacatca cgatacttat tttgttattc ctgctacaat
    13081 taggacagca aatgataccg tgtatcatgc aacctttctt tatcagacag ccagtttgac
    13141 ggatatttta caaaaaacat tgcctatata tcttcttatc tggtttttgg cttgtatcgt
    13201 tgttatcgtg ctgacccgtt atctgctgaa aaagtcgttt gctccaacgg aacgaatact
    13261 gcaaagccaa aaagattttg ttgcaacagc gtcccatgaa ttaaaatctc cacttgctgt
    13321 tatgatttcc aacacggata tgcttcttga taatgtttcc ttaaacgagc aggcaaagca
    13381 agccgtacag accatagatt ttgaatgtat gcggttatcc cgtttagtca aagatatgtt
    13441 gcttttggct tcttccgacg ctaaaacatg gacattgcat aaaagcacaa tcaatgtaga
    13501 taccttgctc attacgttat atgaaaccta cgaacccgtc tgcatgaagc agaatttaga
    13561 actaaaactg catttatccg aggaaagtta tcctgctatg tttaccgaca aagaccgatt
    13621 atttcaaatc ttgtgtgtct ttatggataa tgccattcaa cattccaaga ataattcttt
    13681 aatagagata gaagtaatcg ccaccgaaaa aaatattgct ttttctgtgg tagaccacgg
    13741 gcaaggcatt tctgatgaag ataagcagta tatctttgac cgattttata gtggcgacaa
    13801 gtcccatacg aacaaatcga attttggact gggactaagt atcgccaaag aattaactca
    13861 aatgctgaac ggtattatca ttatcaatga tactgctggt ggaggtgcta cttttactgt
    13921 taaatttcct ctgaaataga ttaaggcttg cagatcatac actatgtatg gagcaagcct
    13981 tttttcaaat ctttgtcttt ttggtaatct tgtaaatata ttcttctggg gtagggcgtt
    14041 tattaccaaa atactttttg aaatttgcct gcacttctgg ggcggtgcta ttcatagctt
    14101 catcaatcgt cgcttcaata tctgcccgaa catcagccaa tgatacaccg ccagcttttg
    14161 caccagcttt caacgctttt tttatatctc gcttttttag tcctatcata ataacctttc
    14221 ttatcataat tgcaaattta taaattcatt agtattaaaa ctgaaattca aatacattac
    14281 taaaatcatt gttcaagaca taataaactt tatttttttc tgtagaatat acaaatgaaa
    14341 ccctagttgc ccacaagtct ttttgagaaa cagattttaa tactttaaat gcgtcattta
    14401 ctgaaaaatc tttatcatat cctgccaata actctttagc cacttcgtat cttgtatccc
    14461 cagaaacaat gtacggcttt gttatatctg gttttagaat agaataattt gtaataagtg
    14521 aaaaattttc ttgttcatat ctatacccaa ttccaggttc aataattaaa actcgtcctt
    14581 ttttatcaga aagcatagct tgcatagtag catctggtgc ataaataatt tttttctttt
    14641 taacaatgtc caaggcttta tcaaaagaaa tctctgcctt aatgaatttt tctgttaatt
    14701 cagatattgt aatacaatcc tcgctttcta tataccttgc attttcatta ccatgaacat
    14761 aaagaagtgt tcctacatta ccatttttat ttatcccatg aaatgaatga tacagaccgt
    14821 caggcatttt aataccaata taaaatctat tttcttcggt aattacagta tgatcccata
    14881 cagaaaggtc aatatcaaaa ttaaaaccaa caattttatc tataccattg taaacaaatc
    14941 ttgtacacat ataatcactc ctcaaaatac tattttaaat agtcatttaa ctaatctaat
    15001 tagtatttta aaatgttttt gtaagaaagt caataaataa tcataatttt ctaattgtgt
    15061 tattgactac actaattcaa ttagctagaa ttgtgtttgt atgatatttt gaatgaggtg
    15121 cataactatg aaaaccacta aagaagcagt aataaaagca acatcagact tagcagatga
    15181 aaaaggatta aataacgttt cgttaaaagc tgttgctcaa aaattaaaca ttcgtacacc
    15241 atctttatat aatcacatag aaagtttaga taatcttctt ttagaagttg ctcataatgg
    15301 tatgcgtgac atgaatgaaa gaatgatgaa aattgccgtt ggaaaaatag ggaaagaagc
    15361 aattaagtta gtttctatcg aatacctaaa ctatatgatt gaacaccccg gagtttatga
    15421 aacaattcaa tgggctgtgt ggcacggaac agaggaaaca gcaaccattt ttaacaacta
    15481 tctttcatta ttaactactc ttatccaatc gtgcagtctt aacaaagaca aaacacttga
    15541 aatattaaat atgcttactg gaataattca cggttataca actttgcaat taggaaacgc
    15601 tttttctgcc tcagataaag ttagatttga attagctgaa gcgatagata ctttattagt
    15661 cgggattttc cagaagtata aataatatat ttaggcttgc aaatcaatac agaactgcaa
    15721 gcctttttct tttatcctac aatcttccag ttgctatcct tatgtagcac aagctcatac
    15781 tgtgatacct gcgtcgcctt tgtctgatta tcaaggaatt ttaccgctac cttgactttc
    15841 acattatccc cgttctttgt aaagataggg tttaccagtt cagaataaag gtagtccctg
    15901 ccgataggct caatcacatt tccagataca tagtaagcaa gctctttttc tgtggctgtt
    15961 ggatagagct taaagaatgt ttccagaaat gcggtagcgt catttaccgt atcagcgtcc
    16021 acgcttgcgt ctgcttctgg tgtcttaggc tcatagtctg atttttcgat tgctggtgca
    16081 agagtagggt tctgaatgat taccatatcc ccgtcagcgt ctacatggac ttttacagta
    16141 taagtcgctt tcacattgct tgtctgttct ccctctttta tctgctgatc tacttcgtag
    16201 gtagcagaaa aagtgtccgt tcccgattgc tcgatatgcc acacaatcac atctgtaact
    16261 gtggagctgg tcggtatatc cgttctgatt gtatcaacat tcaagtcttg caattccttt
    16321 gtcagataac cgctgattgc ctgcgtcctt gcttcaatcg cttctttgct gttactccat
    16381 gtgtaataag acttcgcaaa gttcttcacg aaattttcta tcccgttggt gtcctgcaaa
    16441 cgaagttcaa tgatttcttt ttcatgggtc gtgtgctggt cgatagccgt aaaattctta
    16501 tacaccccaa agctcacgct tgcgataagc accacccaca acgcaatcat ggttttctta
    16561 tgtgtgccta ccttgacagt acgcaccttt ttttcttttg gttctttgac agtttctgtc
    16621 tgtttcttat ttttcttaaa catattttca agtcctttct attgttttac tcgtcctgca
    16681 ccgattaagt gctgttgcca gtaactacta cttaggtctg catatcctat cgggtcgcct
    16741 gcatgataca tctgattatt tcc
//
LOCUS       DAEPID010000082        16670 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.082, whole genome shotgun sequence.
ACCESSION   DAEPID010000082 DAEPID010000000
VERSION     DAEPID010000082.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 16670)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 16670)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..16670
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.082"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            <1..369
                     /gene="tuf"
                     /locus_tag="KR257_003079"
     CDS             <1..369
                     /gene="tuf"
                     /locus_tag="KR257_003079"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009887863.1"
                     /note="EF-Tu; promotes GTP-dependent binding of
                     aminoacyl-tRNA to the A-site of ribosomes during protein
                     biosynthesis; when the tRNA anticodon matches the mRNA
                     codon, GTP hydrolysis results; the inactive EF-Tu-GDP
                     leaves the ribosome and release of GDP is promoted by
                     elongation factor Ts; many prokaryotes have two copies of
                     the gene encoding EF-Tu; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="elongation factor Tu"
                     /protein_id="HBH0031750.1"
                     /translation="DNIGALLRGVQRNEIERGQVLAKTGSVKAHTKFTAEVYVLKKEE
                     GGRHTPFFDGYRPQFYFRTTDVTGACKLPEGIEMVMPGDNVTMEVDLINSIVVEEGLR
                     FSIREGGRTVASGVVATIIE"
     gene            619..768
                     /gene="rpmG"
                     /locus_tag="KR257_003080"
     CDS             619..768
                     /gene="rpmG"
                     /locus_tag="KR257_003080"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004402360.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L33"
                     /protein_id="HBH0031751.1"
                     /translation="MRVKVTLACTECKQRNYNTTKNKKNNPDRIELQKYCRFCKKHTT
                     HKETK"
     gene            794..1015
                     /gene="secE"
                     /locus_tag="KR257_003081"
     CDS             794..1015
                     /gene="secE"
                     /locus_tag="KR257_003081"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421191.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="preprotein translocase subunit SecE"
                     /protein_id="HBH0031752.1"
                     /translation="MAAQKNDGAKTKKRFSLFGYLKETKQELKRVTWPTKKELFKNTS
                     IVLTVVISCTILVWGIDTILSGALALLLK"
     gene            1035..1577
                     /gene="nusG"
                     /locus_tag="KR257_003082"
     CDS             1035..1577
                     /gene="nusG"
                     /locus_tag="KR257_003082"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421190.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcription termination/antitermination factor
                     NusG"
                     /protein_id="HBH0031753.1"
                     /translation="MSELQEASWYVVHTYSGHENKVKATIEKAVKTRGMEDCIRQVVV
                     PTEEVVETTKTGKEKTRQRKVYPSYVLVKMIITDESWYVVRNTKGVTGFVGPGSKPVP
                     LSEDEVKAMGIDTTDPKVVNSDIDFEIGDTVKVSQGPFSGQIGNIEEIDLENREVKVC
                     INAFGKRTLFVIELEGIEKI"
     gene            1616..2041
                     /gene="rplK"
                     /locus_tag="KR257_003083"
     CDS             1616..2041
                     /gene="rplK"
                     /locus_tag="KR257_003083"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012158357.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L11"
                     /protein_id="HBH0031754.1"
                     /translation="MAKKVIGQIKLQIPAGKATPAPPVGPALGQHGVNIMGFTKEFNA
                     KTADQAGMIIPVVITVYQDRSFSFITKTPPAAVLIKKALNLKSGSGEPNKKKVAKMTS
                     AQVREIAELKMPDLNAASVEAAMSMIAGTARSMGVVIED"
     gene            2112..2810
                     /gene="rplA"
                     /locus_tag="KR257_003084"
     CDS             2112..2810
                     /gene="rplA"
                     /locus_tag="KR257_003084"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421188.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L1"
                     /protein_id="HBH0031755.1"
                     /translation="MAKKGKRYAGALQKVDRTKFYDASEALTLVSDIAGAKFDETVEA
                     HIKLGVDSRHADQQVRGAVVLPHGTGKTKRVLVFAKGEKAKEAEQAGADFVGAEELVQ
                     KIQGENWFDFDIVVATPDMMGVVGRLGRVLGPKGLMPNPKSGTVTFDVAKAIDEIKAG
                     KVEYRLDKTNIIHVPVGKVSFGGEKLTENFTALMDAIIKAKPAAAKGQYLRSITVASS
                     MGPGVKINPARTAE"
     misc_feature    2862..2990
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00557"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="ribosomal protein L10 leader region; Derived by
                     automated computational analysis using gene prediction
                     method: cmsearch."
                     /db_xref="RFAM:RF00557"
     gene            3033..3539
                     /locus_tag="KR257_003085"
     CDS             3033..3539
                     /locus_tag="KR257_003085"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421187.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L10"
                     /protein_id="HBH0031756.1"
                     /translation="MRKAIEIKSEVVSEIVEKLQKSSAAVVVDYKGLTVEEVTELRKQ
                     MREAGVDYKVYKNTLVRRAAKEVGIEQFNDELLVGTNAIAFGYDDPVAPARILKGFMD
                     SHPKMKLKMGIVEGAFYDESKIVEMANIPSREVLIAKLLGSLKAPVSNFAYLIDAIAK
                     KAEGQEEA"
     gene            3597..3962
                     /gene="rplL"
                     /locus_tag="KR257_003086"
     CDS             3597..3962
                     /gene="rplL"
                     /locus_tag="KR257_003086"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000159736.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L7/L12"
                     /protein_id="HBH0031757.1"
                     /translation="MTIEQILEAIENMKVLELNELVKAAEEKFGVSASAPVMVAGAAA
                     GGPAAEEKTEFDVVLTDVGSSKVGVIKAVREITGLGLKEAKEVVDNAPKTVKEGASKE
                     EADQIKEKLEAAGAKVEVK"
     gene            4354..5142
                     /locus_tag="KR257_003087"
     CDS             4354..5142
                     /locus_tag="KR257_003087"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436172.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SDR family oxidoreductase"
                     /protein_id="HBH0031758.1"
                     /translation="MEKLQGKIAVVTAATKGIGLASAEILAKNGATVYLAARSEELAN
                     EVINKISAEGGCAKFVYFNAREEETFTSMIEEVVKKEGKIDILVNNFGSTNPSLDKDL
                     VTGDTDNFFDTVNTNLKSVYLPCKAAIPHMIKNGKGSIVNISSIGSVLPDLSRIAYCV
                     SKAAINSLTQNIATQYAKDNVRCNAVLPGLIATKAALDNMSPEFIKEFLKHVPLNRIG
                     EPDDIAKAVLFYASDDSSFITGDLLEVAGGFGLPTPQFADNILG"
     gene            5613..9329
                     /locus_tag="KR257_003088"
     CDS             5613..9329
                     /locus_tag="KR257_003088"
                     /EC_number="2.7.7.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728819.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA-directed RNA polymerase subunit beta"
                     /protein_id="HBH0031759.1"
                     /translation="MPHPVTIGKRTRMSFSKIKEIADVPNLIEIQVDSYEWFLKEGLK
                     EVFDDISPIEDYTGNLILEFVDYSLDDKPKYDIEECKERDATYCAPLKVKVRLINKET
                     GEIKEQEVFMGDFPLMTERGTFVINGAERVIVSQLVRSPGVYYAEERDKTGKRLISST
                     VIPNRGAWLEYETDSNDVISVRVDRTRKQPVTVLLRALGIGTDAEIIDLLGEDERLSA
                     TLEKDNTKTVEEGLVEIYKKLRPGEPPTVESASSLLNALFFDPKRYDLAKVGRYKFNK
                     KLALCYRIMNKISAEDIINPETGEVFVKAGEKISYDLAKAIQNAGINVVNLLMDDDKK
                     VRVIGNNFVDIKSHIDFDIDDLNIKEKVHYPTLKEILDGYSDEEEIKEAIKSRIKELI
                     PKHILLDDIIASISYEFNIFYNIGNIDDIDHLGNRRIRSVGELLQNQVRIGLSRMERV
                     IKERMTVQDMEAITPQALVNIRPVSAAIKEFFGSSQLSQFMDQTNPLSELTHKRRLSA
                     LGPGGLSRERAGFEVRDVHHSHYGRMCPIETPEGPNIGLINSLGTYAKINEFGFIESP
                     YRKFDKETSTVTDEIHYLTADEEDLFVRAQANEPLTEDGKFVNHRVVCRTVNGAVEMV
                     PESRVDYMDISPKQVVSVATAMIPFLENDDANRALMGANMQRQAVPLVRREAPIIGTG
                     IEYRAAKDSGAVVVARNSGIAERVTADEIIIKREDGNRDRYNLLKFKRSNSGTCINQT
                     PIINKGDQIVKGDVIADGPATDLGEVALGRNCLIAFMTWEGYNYEDAILINERLVKED
                     RLSTIHIEEYECEARDTKLGPEEITRDIPNVGDSAIKNLDDRGIIRIGAEVDSGDILV
                     GKVTPKGETELTAEERLLRAIFGEKAREVRDTSLKVPHGESGIIVDVKVFTRENGDDL
                     SPGVNELVRCYIAKKRKIKVGDKMAGRHGNKGVISRVLPEEDMPFMENGTPLDIILNP
                     QGIPSRMNIGQVLEVHLGLAAKTLGWYVATSVFDGANEYDIMDALEEAGYPRDGKLTL
                     YDGRTGESFDNRITVGYMYYLKLHHLVDEKLHARSTGPYSLVTQQPLGGKAQFGGQRF
                     GEMEVWALEAYGAAHILQEILTVKSDDVVGRVRTYEAIVKGENIPEPGIPESFKVLIK
                     ELQSLCLDVKVLTDEDQEIEVRESVDEDDTIGEFELDVVNHMGEVEESNIIEEIEDDF
                     AENAEDEDIENLEEFTEDDLFEEEIDFDSDDFDM"
     gene            9371..12856
                     /gene="rpoC"
                     /locus_tag="KR257_003089"
     CDS             9371..12856
                     /gene="rpoC"
                     /locus_tag="KR257_003089"
                     /EC_number="2.7.7.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429485.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA-directed RNA polymerase subunit beta'"
                     /protein_id="HBH0031760.1"
                     /translation="MFELNNFESIKIALASPEKIRQWSRGEVKKPETINYRTLKPEKD
                     GLFCERIFGPQKDWECHCGKYRRVRYKGVVCDRCGVEVTKSKVRRERMGHIELAAPMS
                     HIWYFKGIPSRMGLLLDMSPRSLEKILYFASYVVVDPGETGLNEKQLLTEKEYRTALE
                     KYGYTFTVGMGAEAVKTLLQNIDLEQQSKDLRAELKDSTGQKKVRTIRRLEVVEAFKK
                     SGNKPEWMILDAIPVIPPDLRPMVQLDGGRFATSDLNDLYRRVINRNNRLKRLLELGA
                     PDIIVRNEKRMLQEAVDALIDNGRRGRPVTGPGNRPLKSLSDMLKGKQGRFRQNLLGK
                     RVDYSGRSVIVVGPELKFYQCGLPKKMALELFKPFVMDKLVKEGYAHNIKSAKSIVEK
                     VKPEVWDVLEDVIKSHPVLLNRAPTLHRLGIQAFEPILVEGKAIKLHPLVCTAYNADF
                     DGDQMAVHVPLSVEAQAEARFLMLSVNNILAPKDGSPITTPSQDMVLGCYYLTIEAQD
                     GAKGTGMVFKDFNELLLAYYNKSVHLHALVKLKVTLEDGRSSLVESTVGRFIFNENIP
                     QDLGFVDRKENPFALEVDFLADKKSLGKIIDKCFRKHGNTETAELLDYIKALGFKYST
                     LGGITVAVDDMSVPEEKKVFIAEAEAKVDKYEKAYRRGLISDEERYEKVIETWTETTD
                     KVTDALMGGLDRLNNIYIMAHSGARGSKNQIRQLAGMRGLMANASGKTVEIPVKSNFR
                     EGLSVLEYFTSSHGARKGLADTAIRTAESGYLTRRLVDVSQDVIVREIDCGTEDTTEI
                     YAIKEGNEVIEEIYDRIVGRYTIDPILNPETGEVIVEADSMIQEDEAETIVALGIEKI
                     RIRTVLNCKTNHGVCSKCYGRNLATGKEVNIGEAVGIIAAQSIGEPGTQLTMRTFHTG
                     GVAGADITQGLPRVEELFEARKPKGLAVITEVSGRVEIDETGKRKEVNVIPEEGETQT
                     YVIPYGSRLKVKQGQMLEAGDPLTQGFINPHDIVRVNGVKGVQEYIVKEVQRVYRLQG
                     VDVNDKHIEVIVRQMLSKVKVEDPGDTDLLPGGYEDVLTFNECNKDAIDKGLRPAVAK
                     RVLLGITKASLATDSFLSAASFQETTRVLTEAAIKGKEDHLIGLKENVILGKLIPAGT
                     GMKKYRNIAVEKIED"
     gene            13145..13567
                     /gene="rpsL"
                     /locus_tag="KR257_003090"
     CDS             13145..13567
                     /gene="rpsL"
                     /locus_tag="KR257_003090"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001142340.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S12"
                     /protein_id="HBH0031761.1"
                     /translation="MPTINQLVRKSRKALEKKSTAPALQKGYNSLNKKVTDASAPQKR
                     GVCTSVKTVTPKKPNSALRKVARVRLTNGIEVSAYIPGEGHNLQEHSVVLIRGGRVKD
                     LPGVRYHILRGTLDTAGVDKRRQSRSKYGAKRPKEAKK"
     gene            13691..14161
                     /gene="rpsG"
                     /locus_tag="KR257_003091"
     CDS             13691..14161
                     /gene="rpsG"
                     /locus_tag="KR257_003091"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001137493.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S7"
                     /protein_id="HBH0031762.1"
                     /translation="MPRKGNIPKREVLPDPMYGSKVVTKLINNLMVDGKKGKSQRIVY
                     DAFAIVAEKTGEEALEVFNKAMDNIMPVLEVKARRVGGANYQVPIEVRPERRQTLGLR
                     WLVKYTRARGEKGMVEKLAKEIMDAANNTGASVKKKEDTHKMAEANKAFAHYRW"
     gene            14210..16276
                     /gene="fusA"
                     /locus_tag="KR257_003092"
     CDS             14210..16276
                     /gene="fusA"
                     /locus_tag="KR257_003092"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421177.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="elongation factor G"
                     /protein_id="HBH0031763.1"
                     /translation="MARKFPLERTRNIGIMAHIDAGKTTTTERILFYTGQTHKIGETH
                     EGASQMDWMEQEKERGITITSAATTASWKDHRINIIDTPGHVDFTVEVERSLRVLDGS
                     VAVFCAKGGVEPQSENVWRQAETYGVPRIAFVNKMDILGADFYNVVSMMKSRLNSNAV
                     PMQLPIGKEDSFIGIIDLLKMDAVIYKDDLGVEMEETDIPEDMKELAAEWREKLVESV
                     AETDEELMMKYLEGEELTIDELKVAIRKATIACEMNPVFCGTAYRNKGVQLVIDAVLD
                     YLPAPTDIPAIKGILADGEEAERHSSDEEPFSALAFKIMTDPFVGKLAFFRVYSGTLE
                     SGSYVLNATKNKRERIGRILQMHANTREEITKVYAGDIAAAVGLKDTTTGDTLCDPAN
                     PIILESMEFPEPVISVAIEPSSKAAQEKMGIALQKLAEEDPTFTVKTDQETGQTIISG
                     MGELHLEIIVDRLLREFKVEAKVGAPQVAYRETITQPVDVEYKYSKQSGGRGQYGHVK
                     IRVAPQEPGEGYKFTNKTVGGSVPKEYVGPVDMGIQGAMQSGIVAGYPVVDVAVELYD
                     GSYHEVDSSEMAFKMAGSMAFKDAMKKGNAVLLEPYFKVEVVTPEDYMGDVMGDLNSR
                     RGLIQGMEARSGAQVINAFVPLSEMFGYSTDLRSSTQGRATYTMIFDHYEQVPASVAK
                     KIAEGK"
     gene            16369..>16670
                     /gene="tuf"
                     /locus_tag="KR257_003093"
     CDS             16369..>16670
                     /gene="tuf"
                     /locus_tag="KR257_003093"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009887863.1"
                     /note="EF-Tu; promotes GTP-dependent binding of
                     aminoacyl-tRNA to the A-site of ribosomes during protein
                     biosynthesis; when the tRNA anticodon matches the mRNA
                     codon, GTP hydrolysis results; the inactive EF-Tu-GDP
                     leaves the ribosome and release of GDP is promoted by
                     elongation factor Ts; many prokaryotes have two copies of
                     the gene encoding EF-Tu; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="elongation factor Tu"
                     /protein_id="HBH0031764.1"
                     /translation="MAKAKYERTKPHVNIGTIGHVDHGKTTLTAAITKTLYDRYQLGE
                     AVDFANIDKAPEERERGITISTAHVEYETPNRHYAHVDCPGHADYVKNMITGAAQM"
BASE COUNT         6554 a         2091 c         3403 g         4622 t
ORIGIN      
        1 gataatatag gagcattatt aagaggagta caaagaaacg agatagaaag aggacaagta
       61 ctagcaaaga ctggatcagt aaaggcacac acaaagttta cagcagaagt atatgtactt
      121 aaaaaagaag agggtggaag acatacacca ttctttgatg gatatagacc acaattctat
      181 ttcagaacaa cagacgtaac aggagcttgt aagttaccag aaggaataga gatggtaatg
      241 cctggagata acgtaacaat ggaagtagac ttaataaact caatagttgt agaagaggga
      301 ttaagattct caataagaga aggtggaaga acagtagctt caggagttgt tgctacaata
      361 atagagtaat tctttactaa actgatggat taaaaggaat aacaaaaaga ggggttatgc
      421 tcctcttttt ttaacataga aatacaaaaa cattgacaca gcataggatt ttgtgataac
      481 ttatacaagg taatgattat aggaagttaa taatatcttg aatactgtag atttttaata
      541 aatacatatt ttaaagatat tatattcaca tatattaaca atatatatta ttgtattaca
      601 aagttggagg tgtatcagat gagagttaaa gtaactttag catgtacaga gtgtaagcaa
      661 agaaactaca acactactaa gaataagaaa aataatccag acagaataga attacaaaaa
      721 tattgtagat tctgtaaaaa gcatacaact cataaagaaa caaaatagtt ttttataagg
      781 atgtgagtat ggaatggctg cccaaaaaaa tgacggtgca aaaactaaaa aaaggtttag
      841 tttgtttgga tacttaaaag aaactaaaca agaattaaaa agagttacat ggccgacaaa
      901 aaaggaactg tttaaaaaca caagtatagt tttaactgta gttatttcat gcactatatt
      961 agtatggggt atagacacta tattatctgg tgcactagcg ttattactaa aatagacgaa
     1021 aagaggtaag ttaaatgtca gaattacaag aagcaagttg gtatgtagtt catacctatt
     1081 cgggacatga aaataaagtt aaagctacaa ttgagaaagc agttaaaaca agaggtatgg
     1141 aagactgcat aagacaagta gttgttccaa cagaagaagt agtggaaact actaaaactg
     1201 gaaaagaaaa aactagacaa cgtaaagttt atccaagtta tgttttggtt aaaatgataa
     1261 taactgatga atcttggtat gtagtaagaa atactaaggg agttacaggt ttcgttggac
     1321 ctggttcaaa accagtgcca ttaagtgaag acgaagtcaa agctatgggg atagacacaa
     1381 cagaccctaa agtagtaaat agcgatattg attttgaaat aggagataca gtaaaagtat
     1441 ctcaaggacc atttagtgga caaataggta acatagaaga aattgactta gaaaatagag
     1501 aagtcaaagt atgcataaat gcatttggta aaaggactct atttgtaata gagcttgaag
     1561 gtatagaaaa aatctaatac tatattatag aaaaatctga ggaggtgcgc tcaaaatggc
     1621 taaaaaagtt ataggtcaaa taaaattaca aatacctgca ggaaaggcta ctccagcgcc
     1681 accagttgga ccagcattag gacaacatgg tgttaatata atgggattca caaaagaatt
     1741 taatgctaaa actgcagatc aagctggaat gataatacca gttgttataa ctgtatatca
     1801 agatagatca ttcagtttta taacaaaaac tccaccagct gcagttttaa ttaaaaaagc
     1861 attaaactta aaatcaggtt ctggagaacc aaacaagaaa aaagttgcta aaatgacttc
     1921 agctcaagta agagaaatag ctgaattaaa gatgcctgac ttaaatgctg catcagtaga
     1981 agctgctatg agtatgatag ctggtactgc tagaagcatg ggtgttgtaa tcgaagacta
     2041 gttaaaagat acactttttt ttataaagtg ggaggctaga agccgaaatt aaccacgagg
     2101 aggaaaataa aatggctaaa aaaggtaaaa gatatgcagg tgcattacaa aaagtagata
     2161 gaactaaatt ttatgatgca tcagaagcat taacattagt ttcagatata gctggagcta
     2221 aatttgatga gacagtagaa gcacacatta aattaggtgt tgactcaaga catgctgacc
     2281 aacaagtaag aggtgcagtt gtattacctc atggaactgg taaaacaaaa agagttttag
     2341 tttttgctaa aggtgaaaaa gctaaagaag ctgaacaagc tggtgctgac tttgtaggag
     2401 ctgaagaatt agttcaaaaa atacaaggtg aaaactggtt tgactttgat atagtagttg
     2461 ctactccaga tatgatgggt gtagtaggta gattaggtag agtattagga cctaaaggtt
     2521 taatgccaaa ccctaaatca ggaacagtta catttgatgt agctaaagct atagatgaaa
     2581 taaaagctgg taaagttgaa tacagattag acaaaactaa cataatacac gttccagtag
     2641 gaaaagtatc atttggtgga gaaaaattaa ctgaaaactt tactgcatta atggatgcta
     2701 taataaaagc taaaccagct gctgctaaag gacaatattt aagaagtata acagtagctt
     2761 cttcaatggg acctggagtt aaaataaacc cagcaagaac agctgaataa taaaactgtt
     2821 gacacaggtt gacaaaaatg ttattatatc acttgtcaat gtaaaaaaga atagatttgc
     2881 cgtagatagt gggtgcgaaa gcttaatatc ccgccgaggt tttagataaa ttgagattac
     2941 taaagctttt gatgtctact tttggcaaca aaagcttttt ataatgttgc ggtaaatact
     3001 aagcctattt ggtgaaggag gtgcacatct atatgagaaa agctatagaa attaaatcag
     3061 aagttgtttc tgagatagtt gaaaagttac aaaaatcttc tgctgctgtt gttgtagatt
     3121 acaaaggatt aacagttgaa gaagtaactg agttaagaaa acaaatgaga gaagctggtg
     3181 tagattacaa agtatacaaa aatactttag ttagaagagc agctaaagaa gttggtatag
     3241 agcaatttaa tgatgaatta ttagttggaa ctaatgccat agcatttgga tatgatgatc
     3301 cagttgctcc agctagaata ttaaaaggat tcatggattc tcatccaaaa atgaaattaa
     3361 agatgggtat tgtggaaggt gcattctatg atgaatctaa gattgttgaa atggctaaca
     3421 taccatcaag agaagttctt atcgctaaat tacttggtag cttaaaagct ccagtatcaa
     3481 acttcgcata cttaatagat gcaatagcga aaaaggcaga aggtcaagaa gaagcttaat
     3541 tgcttaacta aaaaattata aatattaatt tgaaataaaa ttcggaggtg ctaaaaatga
     3601 caatagaaca aatattagaa gctatagaaa atatgaaagt tttagaatta aatgaattag
     3661 ttaaagctgc tgaagaaaaa ttcggtgtat cagcttcagc tccagtaatg gtagctggtg
     3721 cagctgctgg tggaccagct gctgaagaaa aaactgagtt tgatgtagta ttaactgacg
     3781 ttggttcttc aaaagttgga gttataaaag cagttagaga aataacagga ttaggattaa
     3841 aagaagctaa agaagtagtt gacaatgctc ctaagacagt taaagaagga gcttctaaag
     3901 aagaagctga tcaaataaaa gagaaattag aagctgctgg agctaaagta gaagttaagt
     3961 agtttcttta aaaagatacc cattgggtat ctttttttat ttataaaaaa ctataaagaa
     4021 agtatttgga attataaaga aagtattttt ataaaataaa aaaaatttat ataatagtac
     4081 taaattaagg gtatcatata tggtgtaatg gtattttaat ttaacattat tatcaaatta
     4141 aaatataaac aattgttgta atgtctatat ataaagtata taattaaact aaaatgtaaa
     4201 attttacatt ttagtttaaa aaaatacacg aatgttttat aaataaaatg taataaataa
     4261 ttaattaaca aatataaatt ttaaaataag ttagatattt agaaaaatcg aaatttgtag
     4321 gatttaaagg acatattcaa ggaggagtta ataatggaaa aattacaagg aaaaattgca
     4381 gtagttactg cagcaacaaa aggtattgga ttagcatcag cagagatatt agcaaaaaat
     4441 ggagcaactg tgtacttagc agctcgttca gaagaattag ctaatgaagt tataaataaa
     4501 ataagtgcag aaggtggttg tgctaagttt gtttacttta atgctcgtga agaagagacc
     4561 tttacctcaa tgatagaaga ggtagttaaa aaagaaggta agatagatat acttgtaaac
     4621 aattttggtt caacaaaccc ttctcttgac aaagaccttg taactgggga tacagataat
     4681 ttctttgaca cagtaaatac taatttaaaa agtgtgtatt taccatgtaa agcagcaatt
     4741 cctcatatga taaagaatgg aaaaggaagt atagtaaata tatcaagtat aggttcagta
     4801 ttacctgatt tatctagaat agcttactgt gtatcaaaag cagcaatcaa ctcattaact
     4861 caaaatatag ctacacaata tgctaaagac aatgttagat gtaatgctgt acttccaggg
     4921 cttattgcaa ctaaagcagc attagacaat atgtctccag agttcataaa agaattttta
     4981 aagcatgttc ctttaaatcg tataggggaa ccagatgata tagcaaaagc tgttctattc
     5041 tatgctagtg atgactcatc atttataaca ggggatttac ttgaagttgc aggaggattt
     5101 ggtttaccta ctccacaatt tgcagataat atattaggat aattaaatta ctaatatgca
     5161 atgaaagctt atgcattagt tatagtagaa atgatatttt tataaaggcc atagatataa
     5221 tttatattgg aaaggtttga ggttcaaaat tccaagttaa atttatttat ggtctttatt
     5281 ttgtatattt taataaattg tatatatttg tataaatgta attatttaca atcattttaa
     5341 tatggaatta taattaaata ggggggatgg tacttgtata aaatttttta tagaaaatta
     5401 gacctataaa tgaaaaatat ggattttata ttggaaaatt gtacataata cataatatat
     5461 gcttaaaata atttacaaaa aatcaaaaat aatgcatagt ttacatataa gataaaaaat
     5521 atattgaaaa atacttgaca ttatgctaaa attattagat gcgttagaat gaactattgt
     5581 tttattttta attattgaga ggtgaaaagt gaatgccaca tcctgtcacg ataggtaaaa
     5641 gaactagaat gagcttttct aaaattaagg aaatagctga tgtgccaaat cttatagaaa
     5701 ttcaagtaga ttcctatgag tggtttttaa aagaaggttt aaaagaagtg tttgatgata
     5761 tttcaccaat agaagattat actggtaatc ttatattgga atttgtcgac tattctctag
     5821 atgataaacc aaagtacgat atagaagagt gtaaagagag agatgctaca tattgtgcac
     5881 ctctaaaggt taaggtaaga cttataaata aagaaacagg tgagataaaa gaacaagaag
     5941 tgtttatggg tgacttccct ttaatgacag aaagaggaac tttcgttata aatggagcag
     6001 aaagagttat agtaagtcaa ttagttagat ctcctggtgt ttactatgcg gaagaaagag
     6061 ataaaacagg taagagattg atttcatcta ctgtaattcc taatagagga gcatggttag
     6121 aatatgaaac agattctaat gatgtaatat ctgtaagagt tgatagaaca agaaaacaac
     6181 cagttacagt tttacttaga gctttaggaa taggaacaga tgcagagata attgaccttt
     6241 taggagaaga tgagagatta tctgctacat tagaaaaaga taatactaag acagtagaag
     6301 aaggtcttgt agagatatac aaaaaattaa gaccaggtga acctcctact gtagaaagtg
     6361 catcatcttt attaaatgct ttattctttg acccaaaaag atatgaccta gcaaaagttg
     6421 gtagatataa attcaataag aaacttgctt tatgttacag aataatgaat aaaatttcag
     6481 cagaagacat aataaatcca gaaactggag aagtatttgt aaaagctgga gaaaaaataa
     6541 gctatgattt ggctaaagcc atacaaaatg caggtataaa tgtagtaaat ctactaatgg
     6601 atgatgataa aaaagttaga gttataggaa ataattttgt ggatattaag tctcacattg
     6661 attttgacat agatgattta aacataaaag aaaaagtaca ttatccaact ttaaaagaaa
     6721 ttttagatgg atatagtgat gaagaagaaa taaaagaggc tataaaatca agaattaaag
     6781 aacttatacc aaaacatata ttattagatg atataatagc ttcaataagt tatgagttca
     6841 atatattcta taatatagga aatattgatg atatagatca cctaggaaac agaagaataa
     6901 gatctgtagg tgaattgtta caaaatcaag ttagaattgg tctttcaaga atggaaagag
     6961 ttataaaaga aagaatgacg gttcaagata tggaagctat aacgcctcaa gcgttagtta
     7021 acataagacc agtttcagct gcaataaaag aattttttgg tagttctcag ttatctcagt
     7081 tcatggatca aacaaatcct ctatctgagt taacgcataa gagaagatta tcagcccttg
     7141 ggcctggagg tctttcaaga gaaagagctg gattcgaagt gcgtgacgtt caccattcac
     7201 actatggtag aatgtgtcca atagagactc cagagggacc aaatatcggt cttataaact
     7261 ctctaggaac ttatgcaaaa ataaatgaat ttggatttat agaatcacca tatagaaaat
     7321 ttgataaaga aacatcaaca gttactgatg aaatacatta tttaactgct gacgaagaag
     7381 atttattcgt aagagctcag gcaaatgagc cattaacaga agatggtaaa ttcgtaaacc
     7441 atagagttgt ttgtagaact gtaaatggtg ctgttgaaat ggttcctgaa agtagagtag
     7501 attacatgga tatatctcct aagcaggttg tatctgttgc cactgctatg atacctttct
     7561 tagaaaatga tgatgccaac cgtgccctta tgggagcgaa catgcagcgt caggcagtgc
     7621 ctctagttag aagagaagca ccaattatag gaactggtat agaatacaga gcagcaaaag
     7681 actctggagc agttgttgtt gctagaaatt ctggtatagc agaaagagta acagcagatg
     7741 aaataattat aaaaagagaa gatggaaaca gagatagata taatctactt aagtttaaac
     7801 gttcaaactc aggtacttgt ataaatcaaa cacctataat aaataagggt gaccagatag
     7861 taaaaggtga tgttatagca gatggtccag caactgattt aggagaagtt gcacttggaa
     7921 gaaactgtct tatagcattc atgacttggg aaggttataa ctacgaggat gctatattaa
     7981 taaatgaaag attagttaaa gaagatagat tatcaacaat tcatatagaa gaatatgaat
     8041 gtgaagctag agatacaaaa ctagggccag aggaaataac tagagatata cctaatgttg
     8101 gagatagtgc aattaagaac ttagatgaca gaggtataat aagaataggt gcagaagtag
     8161 actcaggtga tatattagtt ggtaaagtaa ctccaaaagg agaaactgaa cttactgctg
     8221 aggaaagatt acttcgtgca atatttggag aaaaggctag agaagttaga gatacttcac
     8281 ttaaagtgcc tcatggtgaa tctggtataa tagttgatgt aaaagtattt actagagaaa
     8341 atggagatga tttatctcca ggagtaaatg aattagtaag atgctatata gctaaaaaga
     8401 gaaaaataaa agttggagat aaaatggctg gtcgtcatgg taataaaggg gttatctcaa
     8461 gagtattacc tgaagaagat atgccattca tggaaaatgg aacaccacta gacataatac
     8521 ttaacccaca aggtatacca tcacgtatga acattggtca ggttttagaa gttcatttag
     8581 gacttgctgc taagacatta ggatggtatg tagcaacatc agtattcgat ggtgctaatg
     8641 agtatgacat aatggatgct cttgaagaag ctgggtatcc tagagatggt aaattaactt
     8701 tatatgatgg tagaacaggt gagtcttttg acaacagaat aactgttgga tatatgtact
     8761 acttgaaact acatcactta gtagatgaaa aactacatgc aagaagtact ggaccatact
     8821 cattagttac tcaacagcca ctaggtggta aagcacaatt tggtggacaa agatttggag
     8881 agatggaggt ttgggctctg gaagcatatg gagctgctca catacttcaa gaaatactta
     8941 ctgttaagtc tgatgacgtt gtaggtcgtg ttagaacata tgaagctata gttaaaggtg
     9001 aaaatatacc tgaaccagga atcccagaat catttaaggt tcttataaaa gaacttcaaa
     9061 gtttatgctt agatgtaaaa gtattgacag atgaagacca agaaatagaa gtaagagaat
     9121 ctgtggatga agatgataca ataggtgaat ttgagctaga tgttgtaaat catatgggag
     9181 aagttgaaga aagtaatata atagaagaaa ttgaagatga ttttgcagaa aatgcagaag
     9241 atgaggatat agagaattta gaagaattca ctgaagatga tttatttgaa gaagaaatag
     9301 attttgatag tgatgacttt gatatgtaaa tttaattaat gtaaatctca aatagaaggg
     9361 agagaactcc ttgtttgaat taaacaattt cgagtcgata aaaatagcat tggcttctcc
     9421 agaaaaaata agacaatggt ctaggggaga agttaaaaag ccagaaacta taaattaccg
     9481 tactttaaaa ccagaaaaag atggtctttt ctgtgaaaga atatttggac cacaaaaaga
     9541 ctgggagtgc cactgtggta aatatagaag agttagatat aaaggtgtag tttgtgatag
     9601 atgtggagta gaagtaacta aatcaaaagt aagaagagag agaatgggac atatagagct
     9661 agcggctcct atgtctcaca tctggtactt caaaggtata ccaagtagaa tgggactttt
     9721 acttgatatg tcaccaagat cgttagaaaa aatattatac tttgcctcat atgtggtagt
     9781 tgatccagga gagactggat taaatgaaaa acaattgctt acagaaaaag aatacagaac
     9841 tgctcttgaa aagtatggat atacttttac tgtaggaatg ggtgctgaag ctgtaaagac
     9901 attactacaa aatatagatt tagagcaaca aagtaaagac ctaagagcgg agttaaaaga
     9961 tagtacaggg caaaagaaag ttagaacaat aagaagatta gaagttgtag aggcatttaa
    10021 aaagtctgga aataaaccag aatggatgat tttagatgca ataccagtaa taccaccaga
    10081 tttaagacca atggtacaac ttgatggtgg aagatttgcg acttcagacc taaatgattt
    10141 atatagaaga gttataaata gaaacaatag acttaaaaga ttattagagc ttggagctcc
    10201 agatataatt gtaagaaatg aaaaaagaat gcttcaagaa gctgttgatg cattgataga
    10261 taatggtaga agaggtagac ctgtaacagg acctggaaat agaccactta aatctttatc
    10321 agatatgtta aaaggtaagc aaggtcgttt ccgtcaaaac ttacttggta agcgtgttga
    10381 ctactcagga cgttctgtta tagttgttgg accagaactt aaattttatc aatgtggact
    10441 tccaaagaag atggcattag aattattcaa gccatttgtt atggataaat tagttaaaga
    10501 aggttatgca cataatataa aaagtgcgaa atctatagta gaaaaagtta agccagaagt
    10561 ttgggatgtt ttagaagatg ttataaaaag tcatccagtt cttcttaacc gtgcaccgac
    10621 tctacataga ttaggtatac aagcatttga accaatctta gttgaaggta aggctataaa
    10681 actacatcct cttgtatgta cagcttataa tgcagacttt gatggtgacc aaatggcagt
    10741 tcatgtacct ttatcagtag aagcacaagc agaagcaaga ttcttaatgc tttctgtaaa
    10801 taatatactt gctcctaaag atggttcacc tataactact ccatctcagg atatggtttt
    10861 aggttgctat tatctaacaa tagaagccca agatggagct aaaggaacag gtatggtatt
    10921 taaagacttt aatgaactat tacttgctta ttacaataaa tcagttcatc tacatgcatt
    10981 agtgaaactt aaggtaacac ttgaagatgg aagaagttca ttggttgaaa gtactgttgg
    11041 tagatttata tttaatgaaa atatacctca agacttaggt tttgtagata gaaaagaaaa
    11101 tccatttgca cttgaagttg atttcttagc agataaaaaa tctcttggta aaataataga
    11161 taaatgcttt agaaaacacg gaaatacaga aacagctgaa ttactagatt atataaaagc
    11221 tctaggattt aaatattcta cattaggtgg cataacagtt gctgttgatg atatgagtgt
    11281 cccagaagaa aagaaagtat ttatagctga ggcagaagct aaagttgata agtatgaaaa
    11341 agcatacaga agaggtctaa tctctgatga agaaagatat gaaaaagtta tagagacatg
    11401 gacagaaaca actgataaag ttactgatgc tcttatgggt ggactagata gattaaataa
    11461 tatatatata atggcacatt caggagccag aggttctaaa aaccaaatta gacagctggc
    11521 aggtatgcgt ggtcttatgg caaatgcatc tggtaaaaca gttgagatac cagttaaatc
    11581 taatttccgt gaaggtttat cagtactaga atactttaca tcttcacatg gtgccagaaa
    11641 aggtcttgcc gatacagcta tacgtacagc tgaatctgga tatttaacaa gaagacttgt
    11701 tgatgtaagt caagatgtta ttgtaaggga aatagattgt ggaacagaag atactacaga
    11761 gatttatgct ataaaagaag gaaatgaagt tatagaagag atatatgata gaattgtagg
    11821 aagatatact atagacccta tattaaatcc tgaaactgga gaagttatag ttgaggctga
    11881 ttcaatgata caagaagatg aagcagaaac tatagtagct ttaggaattg aaaaaattag
    11941 gataagaaca gttcttaact gtaaaactaa tcatggagtt tgttctaagt gttatggtag
    12001 aaacttggca acaggaaaag aagttaatat aggtgaagca gttggtataa tagcagctca
    12061 atctatcggt gagccgggta ctcagcttac aatgcgtaca ttccatactg gaggagttgc
    12121 aggagctgat ataactcaag gtctaccaag ggttgaagaa ttatttgaag ctagaaaacc
    12181 aaaaggatta gctgtaataa ctgaagtatc tggtagagtt gaaattgatg aaacaggaaa
    12241 gagaaaagaa gtaaatgtaa taccagaaga aggcgagact caaacatatg taattccata
    12301 tggttctaga ttaaaagtta agcaaggtca aatgctagag gctggagacc ctctaacaca
    12361 aggatttata aatcctcatg atatagtaag agtaaatggt gttaagggag ttcaagaata
    12421 tatagttaaa gaagttcaaa gagtgtatag acttcaaggg gttgatgtta atgataagca
    12481 tatagaagtt atagtaagac aaatgctatc taaagtaaaa gttgaagacc caggagatac
    12541 agatttattg ccaggtggat atgaagatgt attaacattc aatgaatgta ataaagatgc
    12601 tatagataaa ggtctaagac cagcagttgc taaaagagtt ttacttggta taactaaagc
    12661 atctcttgca actgattcat tcttatcagc agcttctttc caagaaacaa caagagtatt
    12721 aacagaggca gcaataaaag gtaaagaaga ccacttaata ggacttaaag aaaatgttat
    12781 attaggtaag ttaataccag caggaacagg aatgaagaaa tatagaaata tagctgttga
    12841 aaaaattgaa gattaatagc atatagagta aagaaatctt gacaaccatt atttgtggtg
    12901 ttaaaatagt aaagtgtgtt gtttaaaagt acactaaggg cttgaacaag ttcttagtga
    12961 cttttagatg gcaataaatg agaactaaaa agcatcaagc tagaaaagtg ctaatatcac
    13021 atatttatgt gttatagaca ttaaattgta agtaacgaat gttacaatca gtcagtatga
    13081 atattcatat tgatgtagtt ggcggtcact gataagatcg aaaatttgga aggaggtgca
    13141 gatgatgcca acaattaacc aattagttcg taaaagtaga aaagcgctag agaagaaatc
    13201 tactgctcca gcattacaaa aaggttacaa ctctttaaat aagaaagtaa ctgacgctag
    13261 tgccccacaa aaaagagggg tttgtacttc agtaaaaaca gttactccta agaagcctaa
    13321 ctcagcttta agaaaagttg ccagagttag attaactaat ggtatagaag tttctgctta
    13381 tataccagga gaaggacaca acttacaaga gcatagtgtt gttcttataa gaggaggaag
    13441 agtaaaagac cttccagggg ttagatacca tatactaaga ggtactctag atacagcagg
    13501 tgttgataag agaagacaat caagatctaa atacggtgcg aagagaccta aagaagctaa
    13561 aaagtaaaaa caattaatga ttgattatag ttcggtgctt taaatatata tatatttacg
    13621 gcatcacggc attaaatgat ttatgtcgag tacctatgat ttaagttaaa taattaagga
    13681 gggaagcgaa atgccaagaa aaggtaatat tccaaaaaga gaagttttac cagatcctat
    13741 gtatgggagt aaggtagtta ctaaattaat aaataatcta atggtagacg gaaaaaaagg
    13801 aaagtctcaa agaatagttt atgatgcttt cgcaattgtt gctgaaaaga caggagaaga
    13861 agctttagaa gtatttaata aagcaatgga taatataatg cctgttttag aagtaaaagc
    13921 aagaagagtt ggtggggcaa actaccaagt gccaatcgaa gttagacctg aaagaagaca
    13981 aacattaggt ttaagatggc tagtaaaata tactagagct cgtggagaaa aaggaatggt
    14041 tgaaaagcta gctaaagaga taatggacgc agctaacaac actggagctt cagttaagaa
    14101 aaaagaagat actcataaaa tggcagaagc taataaagca tttgctcatt acagatggta
    14161 ggatatatag atatcttata aaattgagga tatcataagg aggataacca tggctagaaa
    14221 gtttcctttg gaaagaacta ggaatatagg aatcatggct catatagatg caggaaaaac
    14281 tactactaca gaaagaatcc tgttttatac tgggcaaact cataaaatag gagaaactca
    14341 tgaaggagct tctcaaatgg actggatgga gcaagaaaag gaaagaggta taacaataac
    14401 ttctgccgct actactgctt catggaaaga ccatagaata aacataatag atactcctgg
    14461 acacgtggac ttcacagttg aggttgaaag atctctaaga gttcttgacg gttcagttgc
    14521 tgtattctgt gcaaaaggtg gggttgagcc tcaatcagaa aatgtatgga gacaagctga
    14581 aacttatgga gtacctagaa tagcttttgt aaataaaatg gatatattag gtgcagattt
    14641 ctacaatgtt gtaagcatga tgaaatctag attaaattct aatgcagttc ctatgcaatt
    14701 accaataggt aaagaagatt catttatagg tataatagac ttattaaaaa tggatgctgt
    14761 tatatacaaa gacgacctag gggttgaaat ggaagaaaca gatataccag aagatatgaa
    14821 agaattagct gctgagtgga gagaaaaatt agttgaatca gtagctgaaa ctgatgaaga
    14881 attaatgatg aaataccttg aaggtgaaga acttactata gatgaattaa aagttgctat
    14941 aagaaaagct actatagctt gtgaaatgaa cccagttttc tgtggtacag cttatagaaa
    15001 caaaggtgtt cagttagtaa tagatgcagt tttagattac ttaccagcgc caactgatat
    15061 accagctata aaaggtatat tagcagatgg agaagaagct gaaagacatt cttctgatga
    15121 agagccattc tctgcattag cattcaaaat aatgactgac ccattcgttg gaaaactagc
    15181 gttcttcaga gtttattctg gaacattaga atcaggttct tatgttttaa atgcaactaa
    15241 gaataagaga gaaagaattg gtcgtatatt acaaatgcat gctaatacaa gagaagaaat
    15301 aactaaagtg tatgctggag atatagcagc agcagtagga ttaaaagata ctactactgg
    15361 agacacatta tgtgaccctg ctaatccaat aatacttgaa tctatggaat tccctgagcc
    15421 agttatatct gttgctatag aaccaagttc taaagcagct caagaaaaaa tgggtatagc
    15481 tcttcaaaaa ttagctgaag aagacccaac tttcacagtt aagactgacc aagaaacagg
    15541 acaaactata atatctggta tgggtgaatt acacttagag ataatagtag atagattatt
    15601 aagagaattt aaagtagaag ctaaagttgg tgcaccacaa gttgcatata gagagactat
    15661 aactcaacca gttgatgttg aatacaagta ctctaagcaa tcaggtggta gaggacaata
    15721 cggtcacgtt aagattagag ttgctcctca agagccaggt gaaggataca aattcacaaa
    15781 caaaactgtt ggtggatcag taccaaaaga atatgttggt ccagttgaca tgggtataca
    15841 aggagctatg caatctggta tagttgctgg atatccagtt gtagacgttg ctgttgagtt
    15901 atatgatggt tcttaccatg aggttgactc ttctgagatg gcgtttaaga tggctggttc
    15961 aatggcattc aaagatgcta tgaagaaagg taatgcagtt cttttagagc cttacttcaa
    16021 agtagaagtt gttactccag aagattacat gggagatgtt atgggtgact taaactcaag
    16081 aagaggatta atccaaggta tggaagctag aagtggtgca caagttataa atgcattcgt
    16141 tccactttca gaaatgtttg gatactcaac agacctaaga tcttcaactc aaggtcgtgc
    16201 aacttacaca atgatattcg atcactatga gcaagttcca gcttcagttg ctaagaaaat
    16261 agctgaagga aaataattta aaaataatta ataatataaa tataaaaaat aatcagctag
    16321 atgagagata tctctcatct agcacaagat aaagggagga aattcaaaat ggctaaagct
    16381 aaatacgaaa gaacaaaacc tcatgttaat atagggacaa taggacacgt agaccacggt
    16441 aaaactacat taacagcagc aataacaaaa acattatatg acagatatca attaggagaa
    16501 gcagtagatt tcgcaaacat agataaagct ccagaagaaa gagaaagagg aatcacaata
    16561 tcaacagcac acgttgagta tgaaacacca aatagacact atgcacacgt tgactgccca
    16621 gggcatgctg actacgttaa gaacatgata acaggagcag cacaaatgga
//
LOCUS       DAEPID010000083        16496 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.083, whole genome shotgun sequence.
ACCESSION   DAEPID010000083 DAEPID010000000
VERSION     DAEPID010000083.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 16496)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 16496)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..16496
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.083"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            210..887
                     /locus_tag="KR257_003094"
     CDS             210..887
                     /locus_tag="KR257_003094"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891739.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HBH0031765.1"
                     /translation="MYNLLVVDDDVDILNINQIYFSNIGFNVYTSETAKDAMDIVESI
                     VLDCIILDISLPDIDGYKMCNDIKEKVNIPIIFLSNYEHEEEKVRGFLAGGDDYITKP
                     YSLKELELRIYARMRQYKNITSVPNVLKFSALVINVNSRKVTFDGESIDLTTMEFEIL
                     LFLAENKEQVFSKIEIYNQVWKMPDIGDQHTVQVHIAQMRKKINSLSREHQYIQTVWG
                     KGYKFVP"
     gene            959..2974
                     /locus_tag="KR257_003095"
     CDS             959..2974
                     /locus_tag="KR257_003095"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893921.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="histidine kinase"
                     /protein_id="HBH0031766.1"
                     /translation="MKKYNILKGTLIVLIVSLLAITGLNLLYKYDNKYTYKSIRASNG
                     ILTIDNDTFTKGKLVFLIDDWEFYNHKIFKPNDFTEQDIKPEYVFIGQYPDFSMRKGT
                     QSPYGNATYRMRIKNEGKDKLLSLELPEIFSASEVWINGEMVSKLGDVGTEKYRPKIK
                     NSVVSFIAKKNTEIIINVSNFSHYYSGLYYPPALGETKDISNMMFYRLLFYSIICFTT
                     FAIAIFSLSVWFLSNKSKIYLYFGCMCVFFAIHVSYPFVHLLGLPLVSFTYAVEDLSY
                     FMVVLCIICINGSISKIEENKVYRFLILPLGITMSIISIVIPIILLPYDMYFVNIYGK
                     LIDIYKYIVFIYILMSSLVSIYKKTCSEHISSYILVSVNTVFGISILFDAVTSNRFEP
                     IFTGWQTEYCGFVIVILFSVMMINRNRIIIKENEKLTRNLEHEVEVRTNELTTLLNER
                     KRFLADVAHDLKAPVSAIQAFIDLIKVGNIHVDEETRTYLYAINQKSNEVQNRVRSLQ
                     EFTSQDKSIGISEKICLNNFIKEIYENNLPDTQACGVNFETYVLEKKIYAKINKEMLT
                     RAFENLIYNALTFTPFDGKIILSMDKEDGFAIIKISDNGKGIPPENIPKVFDRFFTER
                     DNNEPKGQGLGLYIVKSIIREHGGEIFVDSELGKGTVFTIKLSLCFL"
     gene            3024..3704
                     /locus_tag="KR257_003096"
     CDS             3024..3704
                     /locus_tag="KR257_003096"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891737.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HBH0031767.1"
                     /translation="MQTKILIIDGDKDNCQKLKGFLEEKGISIDLAYNCEEAIGKIFS
                     NKYDLIFLEIILSDGDGWTLCKKIRNVTTCPIVYMTYINEDQSILNALNSGGDDYLIK
                     PLNLEILYAKVKAILRRMNSYVNNNENNTKLEEYNRTSGVIKLEDKIIKLTPTENKLL
                     NFFIENPEKTLTTKEIYEHVWMNEYLEDNYSVVVAVNGLRKKIEKDYKNPQKIITIRG
                     AGYYFNKE"
     gene            4220..4666
                     /locus_tag="KR257_003097"
     CDS             4220..4666
                     /locus_tag="KR257_003097"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898392.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0031768.1"
                     /translation="MAISDLAFGTECLKTSFQMLFSVISLVNINLLQAQILIAIGGLI
                     SILAMVSLTLFLSAKCKDSLTSMLIAFSICLIPMGIGVSWIGYLLPPGGIGFKISLLY
                     QMTSFNFLHLGGMSFWTPHIILFFSVIEIPIFIFLAIRTYCKHQVP"
     gene            5047..5964
                     /gene="pstC"
                     /locus_tag="KR257_003098"
     CDS             5047..5964
                     /gene="pstC"
                     /locus_tag="KR257_003098"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903680.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphate ABC transporter permease subunit PstC"
                     /protein_id="HBH0031769.1"
                     /translation="MIVKSRLVGLEKNDNNGNKTKYVIEKVAKNIFLLSALVAVASLL
                     LIIGFVFYKGLRPFIFEGYSFIDFLTGADWVPSANKFGISSMIVASIFATLGALVIGV
                     PVGILTSVFIAEVAPKRLAKIMSPAVELLAGIPSVLYGVFGLAVIVPTIQGIFNLPKG
                     QSLLAIVIVLAVMMLPTIISVSETAIRAVPKAYKEGSLALGASKIETIFKVVLPAAKS
                     GVLAAVVLGVGRALGETMAVILVAGNSPVMPTAITDSVRPLTTNIALEMGYAFGTHQE
                     MLFATGVVLFTFILILNLVLNKLSNKAVN"
     gene            5966..6790
                     /gene="pstA"
                     /locus_tag="KR257_003099"
     CDS             5966..6790
                     /gene="pstA"
                     /locus_tag="KR257_003099"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003460575.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphate ABC transporter permease PstA"
                     /protein_id="HBH0031770.1"
                     /translation="MRKFKENLLKSLVYLSALFTIVSLVVIVGFIFIKGIGNMNFNFL
                     FSNYSASGDGGILPMIITTLYTVVVSIVVATPIGILAAIYLQEYAKKGKAVTAIRFAT
                     ESLSGIPSIVYGLFGGIFFVVTLKMGYSIVAGSLTVAIIILPVIIRTTEEALKTVPQA
                     YRESSLALGATKFQTLYKVVLPSAIPGILSGVILSVGRIIGESAAILLTAGTVAKMPG
                     GIFDSARTLTVHSYLLTKESGDIATAASIGIVLIVIVLALNMLARFVAKKLNKANY"
     gene            6809..7573
                     /gene="pstB"
                     /locus_tag="KR257_003100"
     CDS             6809..7573
                     /gene="pstB"
                     /locus_tag="KR257_003100"
                     /EC_number="7.3.2.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003432349.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphate ABC transporter ATP-binding protein"
                     /protein_id="HBH0031771.1"
                     /translation="MELIDKIKMSVKDLDLFYGDKQALKKINMDIKENKVTALIGPSG
                     CGKSTFIRTLNRMNDLIEDVTIKGNISVDGEDIYTSDDVINLRTKVGMVFQKPNPFPM
                     SIYDNVAYGPRTHGLRDKKQLDKIVEESLKGAAIWDEVKDRLKSSALGLSGGQQQRIC
                     IARAIAMRPEVILMDEPTSALDPISTLKVEELIEDLKKDYTIVIVTHNMQQAARISDE
                     TAFFLNGEVIEFSDTKTMFTTPVDKRTEDYITGRFG"
     gene            7601..8254
                     /gene="phoU"
                     /locus_tag="KR257_003101"
     CDS             7601..8254
                     /gene="phoU"
                     /locus_tag="KR257_003101"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003432348.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphate signaling complex protein PhoU"
                     /protein_id="HBH0031772.1"
                     /translation="MVNNSLDISIDTLKEQTVLMMEKCEEAIEKSVTCMIEKDLEGAR
                     KVVEDDEEINKLREEIRDKSIELIVLKQPMARDLRFIYSLGNISIELERIGDYAANIA
                     REMLKIGGEAYIKELIDIPKMAKECKSMMSQTREALILFDASIAYDVGTKDDIVDGLY
                     EQVQIDCLKIMHENSNTIDQGVKLLLIGRYLERIGDHITNVCEKIIFAIEGKMVEIG"
     gene            8412..9281
                     /locus_tag="KR257_003102"
     CDS             8412..9281
                     /locus_tag="KR257_003102"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422131.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="FUSC family protein"
                     /protein_id="HBH0031773.1"
                     /translation="MKLQKMGMRTIKTGISVTLCMILGDYLVENMFYSLVACIISVQD
                     TVKGSLKTGINRVEGTILGGIIGFIFAIIKAGDPFLCGLGVMCSIYLCNLFKIKSVVV
                     ACVTFLAIHLGVGNSDPVYYSLHRVLDTSVGVLFGVLVNYYVARPNYLNSVIDEFKKI
                     EELSMLLIEDKILRKENLNVEKFEEEVEKLEEIYSKLIDELDYSLSETNIEKIENALR
                     ICREIHFHMQSIELLENKLYLKEHTYKYLKKTYNVDKLDWNIDEEKSPVFNYHLMKIM
                     IEIELLRKLNKSY"
     gene            9368..10804
                     /locus_tag="KR257_003103"
     CDS             9368..10804
                     /locus_tag="KR257_003103"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891715.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="iron hydrogenase"
                     /protein_id="HBH0031774.1"
                     /translation="MNTRNDNSKILEIYKMKLFGELVKAVWNDDIEDIENLPNKILNE
                     DLKDNLNNYFSGKFDKDTMVNLIRVTMGLDVTEDTDKNLKESLHEAVNLDEVKRPIIS
                     VISDACKYCDENNKEDESCKIRSKHINCNEEDVCSACGDCVSRCKLGAISDKIEFIPM
                     IKLLKDIKSPVYAIVAPAFVGQFGKDVSPGKLRTALKKIGFEDMIEVALAADMLTAKE
                     AYDYYEHMKKDEEGCFITSCCCPIWVSLIQNSFPQILENVSPSVSPMIACGRAVKILN
                     PDAKVVFIGPCMAKKKEAMLEDIKDAVDFVLTFKELQEIFDALELNPAIMDESNRVEA
                     SLSGRVYARTGGVSKAVKLSVRRIDKNIKFEEKAFEGTKECMDGLKKVLNKEIEATFI
                     EGMGCVGGCVGGPKRILSVEEGTKNVDEYSESTNMETPFDNLNVLQFLTSLGIKRVES
                     LGEKEEEKVKKIFSRDIKSNKKENKYKK"
     gene            10852..11679
                     /locus_tag="KR257_003104"
     CDS             10852..11679
                     /locus_tag="KR257_003104"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898389.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="polysaccharide deacetylase family protein"
                     /protein_id="HBH0031775.1"
                     /translation="MKIKDNKAVFHVFIRIFLIAVLILTGTLLEEKINNVPVENISSK
                     GENTLELLSQSNTLGEIIYKASQEETKGPGATSEKVAYITIDDGPSKYTNALLDILKE
                     NDVKATFFMLNQNMKNHKEEVRRVLEEENSIGFHSVSHDIHKLYKSPEVTVGEFNTCN
                     NTLQEITGQSSKLIRLPYGSKPYMPEGSYNKLMANDYLIWDWNLDTQDWKSSTSQIVS
                     NILYYGRKRDELVVLIHEKEQSLNALNNIIRILKERGYTILPITENITPKNFWQENL"
     misc_binding    11975..12237
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00230"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="T-box leader; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /bound_moiety="tRNA"
                     /db_xref="RFAM:RF00230"
     gene            12313..14979
                     /locus_tag="KR257_003105"
     CDS             12313..14979
                     /locus_tag="KR257_003105"
                     /EC_number="6.1.1.9"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861890.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="valine--tRNA ligase"
                     /protein_id="HBH0031776.1"
                     /translation="MENTNLSKTYNPKDFEARLYKKWMDEGYFKSKPNPDKKPFTIMM
                     PPPNITGQLHMGHALDHTLQDILIRWKRMDGYEAFWLPGTDHASIATEVKVVERIKKQ
                     EGKTKYEIGREEFLKRAWEWKDEFGGKISNQLKQLGDSCDWDKERFTMDEGCNEAVIE
                     FFVSLYEKGHIYRGNRIINWCPDCKTTLSDAEVEHEEHDGNFYHIKYPLKDSEDFLEI
                     ATTRPETMIGDTGIAVNPEDDRYKHLIGKTAILPLVGRELPIVADSYVDLEFGTGAVK
                     MTPAHDPNDFEVGLRHNLEQLNTMNEDGTMNEVCGKYEGMDRFECRKAIVADLKEQGY
                     LIKIKEHNHNVGTCYRCHTVVEPRLSEQWFVKMEELAKPAIDILKKGELEFVPDKFDK
                     TYLQWLENIRDWCISRQLWWGHQIPAYYCQECGEIVVARKMPDKCPKCGSTHFKQDED
                     ALDTWFSSALWPFSTLGWPNKTEALDYYYPTSVLVTGYDIIFFWVVRMAFAGMFCMNE
                     KPFDHVLVHGLVRDSQGRKMSKSLGNGIDPLEIIEQYGADALRFTLTTGNSPGNDMRF
                     YMERVEFARNFANKLWNASRFVFMNIDEDIIKNMTRESVKEDLTLADKWIISRANNIV
                     KEATNNMDKFDLGIALQKIYDFTWSEYCDWYIEMVKPRLYGEDANAKSAALYTLTYVL
                     EKILKLLHPYMPFITEEIYTHLPTVEGCIIVSEWPKYNEEDNMAEEEDMMNLLMEGIR
                     SIRNVRAEMNVPPSKKAKLIIIPSEEKIEAIELGKDYFITLASASNVEIAKDKSNVPE
                     DAVGVVIDGVEIFIPLNELVDFEKEIERLSKEKKKLEGEIKRVNGKLANQGFLAKAPE
                     SLIEEEKAKKEKFEEMIKSVEERLTNLESKIK"
     gene            15404..16114
                     /gene="rgaR"
                     /locus_tag="KR257_003106"
     CDS             15404..16114
                     /gene="rgaR"
                     /locus_tag="KR257_003106"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003432343.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="two-component system response regulator RgaR"
                     /protein_id="HBH0031777.1"
                     /translation="MFRVVICDDEKIQRSILKEFTEKLLSERCLNYQILEFSCGEDLI
                     SKYPEKIDIIFLDIQMKDINGIEVAKKIRKFDEKVEIIFTTAFSEYAPQGYEVRAYRY
                     LVKPIEYSNFAMGVNLCIDNLQRKKERYIVLNSKKGFNRILIDSILYVETVKRDLVVH
                     TIGRDYKANMSMKQAEKLLCENGFFRCHTSFIVNLRRIEDLRDNTITINEQFIPISKY
                     RLKDLKVALTSLLCDIMY"
BASE COUNT         6529 a         1682 c         2959 g         5326 t
ORIGIN      
        1 atcggagact ttaattagta tttaataatg aatcttaatg tttaatacaa tattcaagaa
       61 ttattcaaaa atacttaagt attatagtct agtttgtaaa gatattataa aataataata
      121 ccagttatat atgaaaataa aacattataa tttgtaataa ctataaaact tggaattata
      181 attaaaatac ctttgaatgg agtggtgtaa tgtataattt actggttgta gatgatgatg
      241 ttgatatttt aaacataaat caaatttatt tttctaatat aggttttaat gtatatacat
      301 cagagactgc taaagatgct atggatatag tagagagtat agttttagac tgtataattt
      361 tggatatttc attgccagat atagatggat ataaaatgtg caatgatata aaagaaaagg
      421 ttaacatacc tataatattt ttatctaatt atgagcatga agaagaaaaa gttcggggat
      481 ttttagctgg gggggatgat tatataacaa aaccttatag tttaaaagaa cttgaactta
      541 gaatatatgc tcgtatgagg cagtacaaaa atattacatc agttcctaat gtgttaaagt
      601 tttcagcgtt agtaataaat gtaaattcaa gaaaagtaac ttttgatgga gaaagtatag
      661 atttaactac tatggaattt gaaatattat tgtttctagc tgagaacaaa gaacaagtat
      721 tttcaaagat agagatatat aaccaagttt ggaaaatgcc tgatattgga gatcaacata
      781 cagtgcaggt tcatattgca cagatgagaa aaaaaattaa ttctttaagc agggagcatc
      841 aatacattca aaccgtatgg ggaaaaggat ataagtttgt accataagtg agatactgta
      901 attaataaat agttcttgtt ttatttaata ctactatgaa agagatgtgg ttgatacaat
      961 gaaaaagtat aatatactaa aaggaactct cattgtattg atagtctctc tgctggcaat
     1021 aacaggatta aatcttctgt ataaatatga taataaatat acatataagt ctattagagc
     1081 aagtaatgga attttaacta tagataatga tactttcact aaaggtaaac ttgtcttttt
     1141 gatagatgac tgggagtttt ataatcataa aatatttaaa ccgaatgatt ttacagagca
     1201 agatataaaa ccagaatatg tttttatagg tcaatatcca gatttttcta tgagaaaagg
     1261 gactcagtca ccatatggga atgctactta tcgtatgaga ataaaaaatg aaggcaagga
     1321 taagctacta agtttagagc ttcctgagat tttttccgca agtgaagtat ggataaatgg
     1381 agaaatggtt tctaaattag gagatgtagg aacagaaaaa tatagaccca aaattaaaaa
     1441 ttcagtagta agttttattg caaagaaaaa tacagaaatt ataatcaatg tatcgaattt
     1501 ttcacattat tatagtggtt tgtattatcc gcctgcatta ggagaaacaa aggacataag
     1561 taatatgatg ttttatcgat tactttttta tagtataatt tgcttcacaa cttttgcaat
     1621 agctatattt tcattgtctg tatggtttct ttcaaacaaa agtaaaattt acttatattt
     1681 tggatgtatg tgtgttttct ttgccatcca tgtatcctat ccctttgtac atttgttagg
     1741 actgcctttg gtaagcttta catatgcggt tgaagatttg tcatatttta tggtagtttt
     1801 atgtattatt tgtataaatg gaagtatatc caaaatagaa gaaaataaag tgtatagatt
     1861 tttaatttta ccattaggaa ttacaatgag tatcatatct atagtgatac caattattct
     1921 tcttccatat gatatgtact ttgtcaacat atatgggaag ttaatagaca tatataaata
     1981 tattgtattt atatatatat taatgtcttc gctggtttca atatataaaa agacatgctc
     2041 tgagcatata agttcttata ttttagtttc agtaaacact gtttttggaa ttagcatatt
     2101 atttgatgca gttacgagta atagatttga gcctatattt acagggtggc aaacagaata
     2161 ttgtgggttt gtaattgtta ttttattttc tgttatgatg ataaacagga atagaataat
     2221 aataaaagag aatgaaaaac ttacaaggaa tcttgaacat gaagttgaag tgagaactaa
     2281 tgaacttaca acattgttaa atgaacgtaa aagattcttg gcagatgtag cacatgattt
     2341 aaaggcacct gtttcggcta tacaagcatt tatagatttg ataaaggttg gtaatattca
     2401 tgtagatgaa gagacaagaa cctatcttta tgctataaat caaaagtcaa atgaagtaca
     2461 aaatagagta cgtagtttgc aagaatttac atcacaagat aaaagcattg gtattagtga
     2521 aaaaatatgt ctgaataatt ttattaaaga gatatatgaa aataatttgc cagatacaca
     2581 agcatgtggt gtaaactttg aaacttatgt attggagaaa aaaatatatg caaagataaa
     2641 taaagagatg cttacaagag catttgagaa tttaatttat aatgctttga cctttactcc
     2701 atttgatgga aagataattt tatcaatgga taaagaagat ggatttgcaa ttattaaaat
     2761 ttctgataat ggaaaaggta tacctccaga aaatatacca aaggtatttg acagattctt
     2821 tacagaaaga gacaataatg agccaaaagg gcaagggtta gggctatata ttgtcaaatc
     2881 cattataaga gagcatggtg gagaaatatt tgtagattca gaactaggaa aaggaactgt
     2941 ttttacaata aaattaagtc tatgtttttt ataataatag cttatttaat ataaaagaat
     3001 aatgatattt gggagtgatt ataatgcaaa ctaagatatt gataatagat ggagacaagg
     3061 ataattgcca gaagctaaaa ggatttctgg aggaaaaagg aataagtata gatttagcat
     3121 ataattgtga agaagctatt ggaaaaatat ttagcaataa atatgattta atatttttag
     3181 aaataattct aagtgatggt gatggatgga ctctttgtaa aaaaattaga aatgtaacta
     3241 cttgtccaat tgtttatatg acttatataa atgaagacca aagcatttta aatgctttaa
     3301 attctggtgg agacgattac ttaataaagc ctctaaattt agaaatatta tacgcaaaag
     3361 taaaagctat tttaagaaga atgaactcat atgtaaataa taatgaaaat aatacaaaat
     3421 tagaggaata taatagaact agtggagtaa taaagttaga agataaaata ataaaattga
     3481 ctccaacaga aaataagttg ttaaactttt ttatagagaa tcctgaaaag actttgacta
     3541 ctaaagagat atatgaacat gtatggatga atgaatactt agaggataac tatagtgtgg
     3601 tagttgcagt gaatggatta agaaagaaaa tagagaaaga ttataaaaat cctcagaaaa
     3661 ttataacaat aagaggagca ggatattatt ttaataagga ataataaata tattaatatc
     3721 attaataatt gttataaatg tgaaatacta acgatatcta aactaaatta ttataaaata
     3781 gctgactgta atttaattga taaatcctat tcttctagac tttgccagtt aaattacagt
     3841 cagttttatt atataaaaaa atgcgtaatg gaactattat tttatagatt atatttgaaa
     3901 agatggataa attgtatatc taaatctata tattatttta ttatttaata tatattaaat
     3961 aataaaatag ttaaataata agattaagaa tttcttaata aatccagaag atgctttcga
     4021 ttatataata ttttatattt ttatattatt aattatatgt gttgcaatcg ctgcacctac
     4081 tttttctggt gagtatcaga cacaatcaga tagcatcctt cgttgtacga aacatggaca
     4141 tattcgtcta gcgtttacta aaatattagc tctattttct atatttataa taatgtttgt
     4201 tatatgtatt tctatccatt tggcaatttc tgatttagct tttggtactg aatgtttgaa
     4261 aacctcattt caaatgttgt tttctgtcat tagtctagta aatataaatt tactacaagc
     4321 acagattctt atagctattg gtggtctaat ttcaatactt gcaatggtta gtttaacatt
     4381 atttttatct gcaaaatgta aggattctct tacttctatg ctgattgctt tttctatttg
     4441 cttaattcct atgggaatag gtgttagttg gattggatac ctattaccac cagggggaat
     4501 tggttttaag attagtttat tatatcaaat gacatcattt aatttcttac acttaggagg
     4561 tatgagtttt tggacaccac acattatact gtttttctca gtgatagaaa tacctatttt
     4621 tatatttttg gctattcgta cctattgcaa acatcaagta ccgtaacaat ttgatggaaa
     4681 taatagtgat ataaactaga ggatacaata attatatatg tagtataaaa gttaaattta
     4741 gttaacaaat cttaatagca gatataggta ataaattata cataaactgt attattatct
     4801 atatctgcta ttttaatata gagaaacaac agtatattgt aaagtaaatg tcaaatatag
     4861 ttttaaaagt aaaattaatg ttaaaaagta aatataattt tacacttgct taacttaatc
     4921 ctaatataga tttaacttaa aaaaagtaga ataaaagtat aggaaatttg atgaagacga
     4981 attataaaaa attaaatttt gaatacagaa cgaaaatcga taagtatatt ttaatgggag
     5041 ggtattatga tagtaaaatc tagattagta ggtttagaaa aaaatgacaa taatggcaat
     5101 aagacaaaat acgtaattga aaaagtagca aaaaatattt ttctacttag tgctttagta
     5161 gcagttgcaa gtttactttt gataatagga ttcgtatttt ataaaggatt aagaccattt
     5221 atatttgaag gatattcatt tatagacttt ttaactggtg cagattgggt tccttctgcc
     5281 aataaatttg gaatatcatc tatgatagta gcatcaatat ttgcaacact tggagcactt
     5341 gttataggag tacctgttgg tatattaacc tctgtattta tagcagaagt agcacctaaa
     5401 agattagcaa aaataatgtc accagcagtt gaacttttag caggtatacc ttcagtatta
     5461 tatggtgtat ttggtcttgc agtgatagtt ccaactatac aaggtatatt taatcttcca
     5521 aaaggtcaaa gtttgttagc aatagtaata gtattagcag taatgatgtt accaacaata
     5581 atatctgtat cagaaacagc aataagagca gtaccaaaag catacaaaga aggttcatta
     5641 gcacttggtg catcaaaaat agaaacaata ttcaaagttg tattacctgc tgcaaaatct
     5701 ggagtattag ccgcagtagt gttaggagta ggaagagctt taggtgaaac aatggcagta
     5761 atacttgttg caggcaactc accagttatg ccaactgcaa taacagatag tgtaagacca
     5821 cttacaacta atatagcact tgaaatggga tacgcatttg gtacacatca agaaatgcta
     5881 tttgcaactg gagtagtatt gtttacattt atattaattt taaacttagt tttaaataaa
     5941 ctttcaaata aggcggtaaa ttaagatgag aaagttcaaa gagaatctat tgaagtcatt
     6001 agtatatcta tcagcactat ttacaatagt atcattagta gttatagtgg gatttatatt
     6061 tataaaggga attggcaaca tgaattttaa tttcttattt agcaattatt cagcatcagg
     6121 tgatggtggt atacttccaa tgataattac aacattatat acagtagtag tttctatagt
     6181 tgtagcaact cctataggaa tattggctgc tatatattta caagaatatg ctaaaaaagg
     6241 aaaagcagtt acagctataa gatttgcaac tgaaagttta tcagggatac catctatagt
     6301 atatggatta tttggaggaa ttttctttgt agttacatta aaaatgggat attccatagt
     6361 tgcaggttca cttacagttg caataataat attaccagta ataattcgta caacagaaga
     6421 agctttaaaa acagttcctc aagcttatag agaatcatca ttggcattag gagctacaaa
     6481 atttcaaact ttatataagg tagtacttcc aagtgcaata ccaggaattt tatctggagt
     6541 aatcttatca gttggtcgta taattggaga atcagctgca atattactta cagcaggtac
     6601 tgtagccaag atgccaggtg gaatatttga tagtgcaaga acattaactg tacactcata
     6661 cttactgact aaagagagtg gagatatagc aacagcagcc agtataggaa ttgttttaat
     6721 agtaattgta ttagcactaa acatgctagc aagatttgtt gctaagaaat taaataaagc
     6781 taattattaa atttaagagg tgtgaataat ggaattaatc gataagataa aaatgagtgt
     6841 aaaagatttg gatttatttt atggtgataa gcaagcatta aagaaaataa atatggatat
     6901 aaaagagaat aaggttactg ctttaatagg tccatctgga tgcggaaaat caacttttat
     6961 aagaacgtta aatagaatga atgacttaat cgaagatgta acaattaaag gaaacatttc
     7021 tgttgatgga gaggacatat atacctcaga tgatgttata aatcttcgta ctaaagtagg
     7081 aatggtattt caaaagccaa atccatttcc tatgagtata tatgataatg tggcatatgg
     7141 tcctcgtaca catggactaa gagataagaa gcaattagat aaaattgtag aagaaagctt
     7201 aaaaggtgca gctatttggg atgaggttaa agacaggctt aaatcatctg cactaggact
     7261 ttctggtggt caacaacagc gtatatgtat agcaagagca attgctatga gaccagaagt
     7321 tattcttatg gatgaaccta catctgcttt agacccaatt tcaacattaa aagtagagga
     7381 acttatagag gatttaaaaa aagactacac aatagtcata gttacacata atatgcaaca
     7441 agctgctcgt atatcagatg aaacagcttt tttcttaaat ggagaggtta tagaatttag
     7501 cgatacaaaa actatgttta ccactcctgt agataaaaga acagaagact atataacagg
     7561 tagatttggt taaaatatat aactataaag gagttagaca atggtcaata atagtttaga
     7621 tataagtatt gatactttaa aagaacaaac agtgcttatg atggaaaaat gtgaagaagc
     7681 aatagaaaag tctgtgactt gtatgataga gaaggattta gagggtgcaa gaaaagtagt
     7741 agaagatgat gaagaaataa ataaattaag agaagaaata agagataaga gtatagagct
     7801 aatagtatta aagcaaccaa tggcaaggga cttaagattt atttattcat taggtaatat
     7861 atctatagag ctggaaagaa taggagatta tgcagcaaat atagctagag aaatgttgaa
     7921 gataggtgga gaggcttata taaaagagct aatagatatt cctaagatgg caaaagaatg
     7981 taagtctatg atgtctcaga ctagagaagc tttaatctta tttgatgcaa gtatagctta
     8041 tgatgttgga actaaagatg atattgtaga tggattgtat gaacaagtac aaattgattg
     8101 tttaaaaata atgcatgaaa actcaaatac catagaccaa ggggtaaaac ttctacttat
     8161 aggaagatac cttgaaagaa ttggagacca tataacaaat gtatgtgaga agataatttt
     8221 tgcaattgag ggtaaaatgg ttgagatagg ataaaaaact gctttaaagc agttttttta
     8281 ttgtctaaat taagaaagaa ttgataaaaa aatatgatta atgggtaaat ttaaaaaatt
     8341 gtgatatact aggaacatat taaatatgag gatgcgtatt ttatataagg tgctttttag
     8401 gaggtggaac tttgaaactt caaaagatgg gtatgaggac tataaaaaca ggaattagtg
     8461 tcactttatg tatgattctt ggtgactatt tagtagagaa tatgttttat tctctggtag
     8521 catgtataat ttctgttcaa gatacagtaa aaggttcttt aaagacggga atcaatagag
     8581 tggaaggtac tattttaggt ggtataatag gattcatatt tgcaatcatt aaagctggag
     8641 acccattttt atgtggtcta ggagtaatgt gctcaatata tttatgcaat ctgtttaaaa
     8701 taaagtcagt agtagttgcc tgtgtaacct ttctggctat acatctaggt gtaggaaata
     8761 gtgaccctgt gtattattct ttacataggg tgttagatac atctgtgggt gttttgtttg
     8821 gagtacttgt taattattat gttgctagac caaattatct aaatagtgtt atagatgagt
     8881 ttaaaaagat agaagaactt tcaatgttgc ttattgaaga taaaattctt agaaaagaaa
     8941 atttaaatgt agagaaattt gaagaagaag tagaaaaatt agaagaaata tattcaaaac
     9001 ttattgatga gttggattat agtttgagtg aaactaatat agaaaaaatt gagaatgcct
     9061 taaggatatg tagagaaata cattttcata tgcagtctat agagttactt gaaaataaac
     9121 tttatttgaa agagcataca tataaatacc ttaagaaaac atataatgtg gataagctag
     9181 actggaatat agatgaagaa aaaagccctg tattcaacta tcatctaatg aaaataatga
     9241 ttgaaataga gttgttgaga aagctaaata aatcatatta ataatagtag ttaaataata
     9301 aataaaaaat agtatctttg taaatattaa acatatataa gtttaattta tggaggtact
     9361 attttttatg aatactagaa atgacaattc taaaatacta gaaatatata aaatgaagct
     9421 ttttggcgaa cttgtaaaag cagtgtggaa tgatgatata gaggatattg aaaacttacc
     9481 taataaaatt ttaaatgaag atttaaagga taatttaaat aattatttta gtggaaaatt
     9541 tgataaagat actatggtaa atttaattag ggtaactatg ggattggatg ttacagaaga
     9601 tacagataaa aatttaaaag agtcactgca tgaagctgta aatttagatg aagtcaaaag
     9661 accaataata tctgtaatat cagatgcttg caaatattgt gatgaaaata ataaggaaga
     9721 tgagtcatgt aagataagaa gtaagcatat taattgtaat gaggaagatg tatgtagtgc
     9781 ttgtggtgat tgtgtatcaa gatgtaagtt gggtgcaatt tcagataaaa tagaatttat
     9841 accaatgata aaattgttaa aagatataaa gagccctgta tatgcaatag ttgcaccagc
     9901 ttttgtagga cagtttggga aagatgtaag ccctggtaaa ttaagaactg cattaaaaaa
     9961 gataggattt gaagatatga tagaagttgc tttggcagca gatatgctta ctgcaaaaga
    10021 agcatatgat tattatgagc atatgaaaaa ggacgaagaa ggatgcttta taactagttg
    10081 ttgctgtcct atttgggtta gtttgataca aaatagtttt cctcagatat tggaaaatgt
    10141 atcaccatcc gtttctccta tgattgcttg tgggagagct gtaaaaattt taaatccaga
    10201 tgctaaagtt gtattcatag gtccttgtat ggcaaaaaag aaagaagcaa tgttagaaga
    10261 tataaaagat gcagttgatt ttgtgcttac atttaaagag ttgcaagaaa tatttgatgc
    10321 attagagtta aatccagcaa taatggatga gagtaataga gtagaggcgt ccctttcagg
    10381 tagagtttat gctagaacag gaggtgtaag taaagcagtt aagttatcag ttagaagaat
    10441 tgacaaaaat ataaaatttg aagaaaaggc atttgaagga acaaaagagt gcatggacgg
    10501 tctaaagaaa gttctaaata aagaaataga agctacattt atagaaggaa tggggtgtgt
    10561 aggaggctgt gtaggaggtc cgaagcgtat tttaagtgtg gaagaaggta ctaagaatgt
    10621 tgatgaatat agtgaaagta cgaatatgga aactccattt gataatttaa atgtattaca
    10681 atttttaact tctttgggaa tcaaaagagt agaatcttta ggagaaaaag aagaagaaaa
    10741 ggttaaaaaa atatttagta gagatataaa aagtaataag aaagagaata aatataaaaa
    10801 ataacttttt aagtcttaaa cttatgcttt tataaaaggg agatatgggg gatgaaaatt
    10861 aaagataata aggctgtttt tcatgtattt ataaggatat ttcttatagc tgttttaatt
    10921 ttaactggaa cattattgga ggaaaaaatt aataatgttc cagttgaaaa tataagttca
    10981 aaaggtgaaa atacactgga actgctttct caaagtaata ctttaggaga aatcatatac
    11041 aaagcatctc aagaagaaac aaaaggtcca ggggctactt ctgaaaaagt agcatacata
    11101 acaatagatg atggtccatc aaaatataca aatgcactac ttgatatttt aaaagaaaat
    11161 gatgtcaaag cgacattttt catgcttaat cagaatatga aaaaccacaa ggaagaagta
    11221 aggagagtct tggaagaaga aaactcaata ggttttcata gtgtaagtca tgatatacat
    11281 aagttatata aaagcccaga agtaacagtt ggggaattta atacatgcaa taatactcta
    11341 caagaaataa ctggtcagag ttcaaaatta ataagattac catacggaag taaaccatat
    11401 atgccagaag gttcatataa taaacttatg gcaaatgatt atttaatttg ggactggaat
    11461 ttggatacac aggattggaa gtcttctaca agtcagatag taagtaatat attatattat
    11521 ggaagaaaaa gagatgaatt agtagtatta attcatgaga aagagcaaag tttaaatgct
    11581 ttaaataata ttataagaat cttaaaagag agaggatata caatattgcc aattacagaa
    11641 aatataacac ctaaaaattt ctggcaagaa aacttataat aaatttaaat atagtaaaag
    11701 ataaagtaaa ttatttataa aataaaacat ataatataaa aaatacgaat aagaggtata
    11761 ctgtaaggat aatataaaat taatgagaaa gcattaaaat taaaataaaa taatcttgca
    11821 attattgaca ttataagaca gaataactgt aaaaacatat tttaaaatat aacaactata
    11881 taaaagagaa tagacataat taagaaaatt cagaaaaaat aaaataaaaa taattgacaa
    11941 agagaataat atttgtatat aataatatgt aatattaaag actgagaaga agaggagtaa
    12001 gtaaatacta ctaaaagaga ggaaaattca ctggctgtaa gattttctaa gtataagatt
    12061 tactgaatgt agctttggag tttctaaact gaactataag taagtttaga cggttagaac
    12121 cgttaaattc tttgagagtc aaagttgata aaataacatt aaccaataat ttaattatat
    12181 gttaatgtat tttaagcttt ggaattaagg tggtaacgcg agcttttcgt cctttttaaa
    12241 gaggatgaag agctcttttt tatttctaaa gatatttaaa aaatttattt ataaaataca
    12301 ggaggcagga caatggaaaa tacgaattta tcaaaaactt ataacccaaa agattttgag
    12361 gctaggctat ataaaaaatg gatggatgaa gggtatttta aatctaaacc aaatccagat
    12421 aaaaaaccat ttacaataat gatgccacca ccaaatataa cagggcaatt gcatatggga
    12481 cacgctcttg accatacact tcaagatata ttaatcagat ggaaacgtat ggatggatat
    12541 gaagcttttt ggcttccagg aactgaccat gcttctatag caacagaagt taaagttgtt
    12601 gaaagaataa aaaaacaaga aggcaagaca aagtatgaaa taggtagaga agaattttta
    12661 aagagagcct gggaatggaa agatgaattt ggaggaaaaa tatctaatca gcttaaacaa
    12721 ctaggtgatt cttgtgattg ggataaagaa agatttacta tggatgaagg gtgtaatgaa
    12781 gcagttatag aattttttgt aagcctatat gaaaaaggtc acatatacag aggaaataga
    12841 ataataaact ggtgcccaga ttgcaaaact actttatcag atgcagaagt tgaacatgaa
    12901 gaacacgacg gaaactttta tcatataaag tacccactaa aagatagtga agacttttta
    12961 gaaatagcta caactagacc tgagacaatg ataggagata ctggtatagc agtaaatcca
    13021 gaagatgata gatataaaca tttaatagga aaaacagcaa tacttccatt agtaggaaga
    13081 gaacttccaa tagttgcaga tagttatgtt gatttagagt ttggaactgg tgcagttaag
    13141 atgactccag cacatgaccc taatgatttt gaagtaggat taagacataa tcttgagcag
    13201 ttaaatacta tgaatgaaga tggaactatg aatgaagttt gtggaaaata tgaaggtatg
    13261 gatagatttg agtgtagaaa agctatcgta gcagacttaa aagaacaagg ttacctaatt
    13321 aagataaaag agcataatca taatgtagga acttgttata gatgccatac agtagttgag
    13381 cctagattat cagagcaatg gtttgttaag atggaagaac ttgcaaaacc agctatagat
    13441 attcttaaaa aaggagaatt agaatttgtt ccagataaat ttgataaaac ttatttacaa
    13501 tggctagaaa atataagaga ttggtgtata tcaagacaat tatggtgggg tcatcaaata
    13561 ccagcttatt attgtcaaga gtgtggagaa atagtagttg ctagaaaaat gccagataag
    13621 tgtcctaaat gtggaagcac tcattttaaa caagatgaag atgccttaga tacttggttc
    13681 agttctgcat tatggccttt ctctactcta ggatggccaa ataagactga agctttagat
    13741 tattattatc caacaagtgt acttgttaca ggatacgata taatattctt ctgggtagtt
    13801 agaatggcat ttgcaggtat gttctgtatg aatgaaaagc catttgacca tgttttggtt
    13861 catggattag taagagattc tcaaggtaga aaaatgagta aatctttagg aaatggtatc
    13921 gacccattgg agataatcga gcaatatgga gctgatgccc taagatttac attaacaact
    13981 ggaaattccc caggaaatga tatgagattc tatatggaaa gagtagaatt tgctagaaac
    14041 tttgcaaata agttgtggaa tgcatcaaga tttgtattta tgaatattga tgaagatata
    14101 attaaaaaca tgactagaga aagtgttaaa gaggacttaa ctctagctga taaatggata
    14161 atatcaagag caaataatat tgtaaaagaa gcaactaata acatggataa gtttgattta
    14221 ggaatagcac ttcaaaagat atacgatttt acttggtcag aatactgtga ctggtatatt
    14281 gaaatggtta aacctagatt atatggggaa gatgcaaatg ctaaatctgc agcattatat
    14341 acattaactt atgttcttga aaagatatta aaattattac atccatatat gccatttata
    14401 acagaggaaa tatatactca tcttcctact gttgaaggat gtataatagt atctgaatgg
    14461 ccaaaatata atgaagaaga taacatggct gaagaagaag atatgatgaa cttattgatg
    14521 gaaggtataa gaagtataag aaatgtgaga gcagaaatga atgtaccacc ttctaagaaa
    14581 gctaaattga taataatccc aagtgaagaa aaaatagaag ctattgagct tggtaaagac
    14641 tattttataa ctttagcatc tgcttcaaat gtagagatag caaaagataa atctaatgtt
    14701 ccagaagatg cagttggagt agttattgat ggtgttgaaa tatttatacc tcttaatgaa
    14761 ttagttgatt ttgaaaaaga aattgagaga ttatctaaag aaaagaaaaa gttagaaggc
    14821 gaaataaaga gagttaatgg aaagcttgca aatcaaggtt tcttagcaaa agctcctgaa
    14881 agtttaattg aagaagaaaa agcaaaaaaa gaaaaatttg aagagatgat taaatctgtt
    14941 gaggaaagat taacaaattt agaatctaaa ataaaataaa tataagaatt agtaaaaaca
    15001 tacaaaaagt atatattcta tactttttgt atgtttttct ttatatatat acaaatatga
    15061 tgttataatt ctttacagat gtgttatatt tttattttat gttgtgaata tatgaatttt
    15121 atgtcttaaa atttataagc aataaaaatt tgatatatta tgatgtttaa tatagggtaa
    15181 taaatacata ttatatttat tttactatat ttttttacat aatatatcta gaaaagtata
    15241 ggaatttatc gtaatttaag tttaaatatt aaagagaatt tctataagta gtttaatcga
    15301 caatttaaat ttataaagaa atttaaattt gaaagctagt gagtacagtt tggaaattga
    15361 aataaagtaa actaaatgat attttagatt tggaggtgat attatgttca gggtagttat
    15421 atgtgatgac gaaaaaatac aaagaagcat actaaaagag tttacagaaa aacttttgtc
    15481 tgaaagatgt ctaaattatc aaatactgga attttcctgt ggagaagatt taatatccaa
    15541 atacccagaa aaaattgata ttatattttt agatatccaa atgaaagata tcaatggaat
    15601 tgaggtggct aaaaaaataa gaaagtttga tgaaaaagta gaaattatat ttacaacggc
    15661 tttttcagag tatgcccccc aaggttatga agttcgtgct tatagatatt tagtaaagcc
    15721 tatagagtat agtaactttg caatgggtgt aaatctttgt attgataacc ttcaaagaaa
    15781 gaaggagcgt tatatagttt taaatagtaa aaaaggattt aatagaatac tgatagattc
    15841 tattttatat gttgaaactg taaagagaga tttagttgta catacaatag gtagagatta
    15901 taaagctaat atgagcatga aacaagcaga aaaattactg tgtgaaaatg gcttttttag
    15961 atgtcataca agttttattg ttaatttaag aagaatagaa gatcttaggg ataatacgat
    16021 tactattaat gaacaattta tacctataag taagtataga cttaaagatt taaaagtagc
    16081 attaacaagc ttgttatgtg atataatgta ttaattttaa aaaggtaatt gaaaatatcg
    16141 taaaaaagat ttaatgtcat cacagggcta ttgattgaaa ctgtcttaat atataaaatg
    16201 ttatttatat taagacagtt ttattatgca aaatagcagt ttatagactt ttaatatggt
    16261 ttaatatgta tatgtagagt ttccattata atagcatgat tattaattag tagcttgatt
    16321 atcaatatac tattattgat ttttatatgt attatatgta tttttagaat atgattacct
    16381 ttttaaaata atgactattt ataaaactct atagatattt gtttcattta gctatgcata
    16441 ctttaattaa ttatattaat atttaatgga gtacaatata aatattaaag cgacat
//
LOCUS       DAEPID010000084        16209 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.084, whole genome shotgun sequence.
ACCESSION   DAEPID010000084 DAEPID010000000
VERSION     DAEPID010000084.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 16209)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 16209)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..16209
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.084"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            243..1691
                     /locus_tag="KR257_003107"
     CDS             243..1691
                     /locus_tag="KR257_003107"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728826.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="family 1 glycosylhydrolase"
                     /protein_id="HBH0031778.1"
                     /translation="MKLGKDFLWGGAISANQSEGFYLDGGKGLSQFDKLPLNDKRLKD
                     VCLDEDNILNENNQYYPSHIGIKFCENYKEDIAMLAEIGFKCFRFSISWSRIFPTGEE
                     SEPNEKGLQLYDNIIKELKKYNIEPLITISHFDIPYSLVEKYSGWADRRVVNLYVKYA
                     EILMKRYKDDVKYWIPFNEMNMIMHIPYIGAGLTFIADENQLQKKYQAAHHQLLANAK
                     TIEIGRYINKEFKFGCMLAAGKTYPYTCKPEDVFATLEHERHNLFFSDVQVRGVYPSF
                     MNYYLKSNQIKLIIKEEDLSTLKDNTVDFVSFSYYSSACSSARAEGLEKSKANGPETI
                     KNPYLPKSNSVWQNDPVGLRITMNQLYERYQLPLFIVENGLGTQDIVNEDGKIIDDYR
                     IDYMKEHIKNMIIGVNEDGIELIGYLMWGCIDVTSVSEGKMTKRYGIIHVDSDDYGRG
                     SFKRTKKQSAFWYKKVIETDGEILFNDMETHA"
     gene            1717..4107
                     /locus_tag="KR257_003108"
     CDS             1717..4107
                     /locus_tag="KR257_003108"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893828.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycoside hydrolase family 65 protein"
                     /protein_id="HBH0031779.1"
                     /translation="MSLIFTTKDQLIEQGFSKDTIKSNETLFTLANGHLGVRGNIEES
                     DFNNEYVDNMGTYVNGFYEESPITYGESAYGYAKQNQTICKLPNAHIVNFSIEGDCFD
                     LSKGITSEHSRILDLNEGILKRSFIWENSRGRKVKVSIERLVSQDIEELMMISYTITP
                     LNFNGKIKFKNKMENSMEKFNCEKVEDPRVASINKKQFKINVKKYNNKYFMNLVTERS
                     RLGLWCGFDSYITCGNITNETYNVSDECIEREIEVYAKKDERLNLEIVVGYSRVYSDL
                     NLNEERLKSLECLESLKCLESEAHLKSLELVLREACNIGFDKVKNIQRKKMNEFWTTS
                     DVEIEGDKTLQLGIKTNLFHIYQSVGRDGKTNISAKGLTGDGYEGHYFWDTEMYILPF
                     FIYTQPSIARALLDYRYSILDASRERARELGINKGCLYSWRTINGNECSAYYPAGTAQ
                     FHINADIAYGIRTYFEATNDEEFMMQNGLEILIETARFWVEFGDYIESKNNKFCINGV
                     TGPDEYTAIVNNNYYTNLMAKYNLIYAVQMVDKFKHNLFSNEVFRKVKLQEYEVKNWI
                     NAAQNMYLPYDEEKKISKQDDSFLEKSVWDFKNTPKEKYPLLLHYHPLTIYRYQVNKQ
                     ADTVLSALLFPDEFSLEQKKRDFEYYEKITTHDSSLSRSIFGMMASEIGNHEKAYNYF
                     MDTALMDINNLQKNTSDGIHAANMGGTWMSLVYGFAGMKIKNDKLSFEPRIPKHWKNI
                     KFNILFRDNLVSVNIEEYKSYYKLIKGRNITILHDNKEIKLSKNIIEVNNCFKGSN"
     gene            4109..4780
                     /gene="pgmB"
                     /locus_tag="KR257_003109"
     CDS             4109..4780
                     /gene="pgmB"
                     /locus_tag="KR257_003109"
                     /EC_number="5.4.2.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891494.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="beta-phosphoglucomutase"
                     /protein_id="HBH0031780.1"
                     /translation="MKAVLFDLDGVITDTAKYHFEAWHEIAKSLDIEIDETFNEKLKG
                     ISREESLDKILLSANKVDSYTKEEKLKVCEEKNNIYIKLINSLTYKDILPGINELIKE
                     LKKNNVKLGIASASKNAPRILESLGIKDEFDCIVNPSLLKRGKPYPDIFIEGSKILNL
                     KQYDCVGIEDSYSGIKAINAANMTSIGVGKKEVLGKCDHIVEDTSLLNYNTLLQAWSK
                     KINLD"
     gene            4819..6189
                     /locus_tag="KR257_003110"
     CDS             4819..6189
                     /locus_tag="KR257_003110"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891492.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS transporter subunit EIIC"
                     /protein_id="HBH0031781.1"
                     /translation="MKNKYEEVAQLIIDGLGGKDNIIDLTHCMTRLRFILKDEKKVNA
                     DKLKSIDKVVGVNSTSTQYQVIIGNEVGVVFNAIINKGINTTGDIKSDIKNKNKKNSI
                     LNNIIDTITGCMTPMIPALTASGMIKVILSLCTTFNWLSSNSSTYRVLDIIGDVAFYF
                     MPIILAINAAKKFNVNTSIAVIVVGVFLHPNFSAWVSSGDPISFIGVPIQDVIYAASV
                     IPALLTVWMMSYIEKFIDKLTPSMLKTILNPTLVLLISAPIALIVIGPIGNFLGEGLA
                     SIINLLQGRLGFIMVCLLAAAMPFIVMTGMHHALTPIFISAFATTGQESLILISQVCA
                     NLAQGGATLAVALRSKDSKMKQLASAAWISAIMGITEPALYGVTLKLKKPAMLASIGA
                     GIAGLFAGITHVTLYVPQNSIMAVLGLSGEKGISNIVNGLIVIFIALVAPFIMTYVFG
                     VEKNVK"
     gene            6536..7378
                     /locus_tag="KR257_003111"
     CDS             6536..7378
                     /locus_tag="KR257_003111"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898228.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PRD domain-containing protein"
                     /protein_id="HBH0031782.1"
                     /translation="MIINKILNNNVVITLDDNDEEVIVMGKGIGYQKSKGNLIDKTKV
                     NKVFRISNKEISNKLQELLNNIPIEHMKLSSEIIEYAQIKLNKKLNESIYISLSDHTY
                     SAIQRMKEGINVKNAILWEIKRFYKEEFEIGMKALDIIENKTGIKLPEDEAGFIAFHI
                     VNAQLSEGHTLASDITKLIQEVLSIVRYHFRIEFHEESVFYYRFIMHLKFFAQRLLLD
                     SAHEGETDKELLSIIKSKYNKEFECVVKIKNFIKKQYNYILTDDELIYLTIHLAKVVK
                     DSNM"
     gene            7523..9451
                     /locus_tag="KR257_003112"
     CDS             7523..9451
                     /locus_tag="KR257_003112"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003440045.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS glucose transporter subunit IIA"
                     /protein_id="HBH0031783.1"
                     /translation="MGKYKQLAQEIVNNVGGKENISGLVHCITRLRFTLKDESIANDN
                     VLKNMEGIVTVMKSGGQYQVVIGNHVEAVYKDVVEIIGLDDSSTSSETKKSGNILDKG
                     IDIISGIFQPVLGIMAACGMLKGFNALFVAMGLYSDVSGGYMVINAAGDALFTFLPLF
                     LGYTSAKKFGLKPMLGLALGAAVCYPAIQGSSISAGADVMYTLFKGTMFASPVYIDFF
                     GLPIVSIDYTGTVVPIIFIVYFASRCEKLFNKCVPNLVKFFFVPMLTLLITVPVALIV
                     IGPIATFGSTLISQIVISIRDFSPLLAGAIVGFTWQILVIFGMHWGFIPVYINNVMTL
                     GYDNVMMPFFACTFASSAVVLAIFFKTKDKKLKEMAIPNFISGIFGVTEPAIYGILLP
                     LKKPFIISCIASGIGGAFYGFFNLRKFITGGMGIFELPAMIEPDGGMGNLIVALSGIA
                     ISMVVAFVLTMILYKDEKVEESKKVRNKGKEEIKEVKSTKLEREIVTSPIKGEVLKLS
                     DIEDAAFASGVLGQGVAIIPSDGKVVAPVDGVVTTLFPSLHAIGILSDTGVEVLIHIG
                     LNTIQLEGRGFEACIKQGDRITKGQTILNFDVYAIKELGYSTVTPIVITNSSQFLDVV
                     ETESKNIELEDNLITVLF"
     gene            9512..10939
                     /gene="ascB"
                     /locus_tag="KR257_003113"
     CDS             9512..10939
                     /gene="ascB"
                     /locus_tag="KR257_003113"
                     /EC_number="3.2.1.86"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898224.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="6-phospho-beta-glucosidase"
                     /protein_id="HBH0031784.1"
                     /translation="MSFKNDFLWGGATAANQCEGGYNEDERGLANVDVCPTGKDRTAV
                     ITGKLKMFDFDDEHYYPAKTGIDMYHNYKEDIKLFAEMGFKVYRMSIAWSRIFPKGDE
                     ETPNEKGLQFYENIFKECKKYKIEPLVTITHFDCPMHLVKKYGAWRNRKMIGFYEKLC
                     NVIFRRYKGLVKYWLTFNEINMILHAPFMGAGICFEEGEDVEKIKYQAAHHELVASAI
                     ATKIAHEVDSNNLIGCMFAAGSVYPYSCNPNDVWEATKLDRENYFFVDVQSKGKYPNY
                     ALKYMEQKGITPEMEPGDIELLNKYTVDFISFSYYNSRCVRTDENADDMAEGNIFTSA
                     KNPYLSYSQWGWPIDPLGLRITLNHVYDRYEKPLFIVENGLGAKDIADENGYVEDDYR
                     IDYLREHIKAMHDAVSIDGVDLLGYTTWAPIDLVSAGTGEMEKRYGFIYVDRDNSGNG
                     SLRRMKKKSFEWYKKVIASNGEDLY"
     gene            11386..12162
                     /locus_tag="KR257_003114"
     CDS             11386..12162
                     /locus_tag="KR257_003114"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898222.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nitroreductase family protein"
                     /protein_id="HBH0031785.1"
                     /translation="MKYQHIIEVDKELCIGCGLCKNDCPVNNIIIENKKSVIKKQDCL
                     MCGHCAAICPTKAITLTGFDEPPIELTNKPKLDSDELLMAIKSRRSIRKFKDKEVSSE
                     IIKQIIEAGRYTPSAKNSQDVSYIVLDNKKSIYENEAVKFFRKIKPIANIAIKYSKEV
                     EIDDNFFFKHAPIAIMIITKDKISGSLAASNMALMAESYGLGVLFSGYFSDVANNSPK
                     LKKLLGLKRSNHVLTTLVIGYPDVKYRRTAQKEVATVRYL"
     gene            12178..12543
                     /locus_tag="KR257_003115"
     CDS             12178..12543
                     /locus_tag="KR257_003115"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003440040.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="winged helix-turn-helix transcriptional
                     regulator"
                     /protein_id="HBH0031786.1"
                     /translation="MEKECQQRMQEITSKFKECRKAISAMGDETRQLILIALLESDFN
                     GIRVGEITKKTHLSRPAVSHHLKILKEAEIVNLRREGTKNYYYLDSKKSQWKSLTELI
                     NLIFVGIQHISENDIRKGD"
     gene            complement(12709..13458)
                     /locus_tag="KR257_003116"
     CDS             complement(12709..13458)
                     /locus_tag="KR257_003116"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003440038.1"
                     /note="N-terminal region resembles flavodoxins. C-terminal
                     ferrodoxin region binds two 4Fe-4S clusters; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="EFR1 family ferrodoxin"
                     /protein_id="HBH0031787.1"
                     /translation="MILYFSGTGNSRYVARKIAQELNDELISLNQLIKEEKTDELISA
                     DKPFIFVCPTYAWRLPIVVTDFIKETKFLGSNRVYFVMTCGGDTAKSINYIQKLCKYK
                     EWQLKGMAEIKMPENYIALFSTTDKETSKQMIKEADKQIYRIISDIRNENEFETITPS
                     GLGGTIKSGIINTVFYKTIISAKGFHYTDKCIGCGKCVELCPLNNINLKNKKPVWKNN
                     CTHCMACICGCPTEAIEYKNKTQNRERYYLE"
     gene            13916..14341
                     /locus_tag="KR257_003117"
     CDS             13916..14341
                     /locus_tag="KR257_003117"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861830.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HBH0031788.1"
                     /translation="MINENLKSLRKINQYTQEELAEKLNVSRQSIAKWESGESIPDIC
                     SCIKLAKLYNVKLDDLVNHSEEKTGIIVPPKGKFFFGAVVVGERGQIVIPKEAREVFN
                     INAGDKLLVLGDEERGLGIVHQRDLINFIGHVGVVRKEE"
     gene            14373..15560
                     /locus_tag="KR257_003118"
     CDS             14373..15560
                     /locus_tag="KR257_003118"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003440033.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glucosyltransferase"
                     /protein_id="HBH0031789.1"
                     /translation="MSKIVFFSIPAYGHTNPTIEVVRELVDRGNEVLYYSFNEFKDKI
                     EGAGAKFICCDKYLPELLPGDEKKIGKDFPGLIEMIVDTTISLDEKVCRELKDFNPDC
                     IVSDSLSFWGKLFAQKLNIPYVCSTTTFAFNKHTAKLMKQNFIEIIRMIFGVRRINKK
                     IKLLQRKGYEVKNFISIVSNDNDTDTIVYTSKEFQPMVETFSSKYSFVGPSVSKLIIE
                     PKERKRKLIYISLGTINNKNVSFYKNCISAFKDSDVDVIMSVGRSTDIKSLGNIPNNF
                     EVKNSVEQIAILQKTDVFVTHSGMNSVNESLYYGVPMVLFPQHSEQRMVAKRVVHLGA
                     GIMLKEDKSESIKKAVFQVINDNEYKENATKLSKSFYNAGGSKKAADVILQIICNSRQ
                     VDI"
     gene            15752..16156
                     /locus_tag="KR257_003119"
     CDS             15752..16156
                     /locus_tag="KR257_003119"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003427327.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3139 domain-containing protein"
                     /protein_id="HBH0031790.1"
                     /translation="MKKYKVIFIVLIIGIISVTGFVVYKNCIKPWKDAETYIDKYMVK
                     QDISKDNIKSITKEKAKKASYEGILYKVYYKDDPRYEYQYFYSDNYYALYVNKVMLQI
                     YDMENNNKLLRSNEELKSVKYPLIYLKYKPDK"
BASE COUNT         6388 a         1695 c         2867 g         5259 t
ORIGIN      
        1 gaataagata acaataatga ggatataaaa atgtatttgc tatatatata attatataca
       61 tagatatcta atattgatat ttaatatgaa agtattgaaa atagacaata ttaattatag
      121 tgagtaaaaa atataattgg atttttaaat tgaattattt aaaaggtata gtatgaaaaa
      181 aatcttataa ctaaatatga gatagaaatt ataaaacttt atattgtgaa agaggtagat
      241 gcatgaaatt agggaaagat tttttatggg gaggggcaat ttcagccaat caaagtgaag
      301 gattttattt agatggagga aaaggtttat ctcagtttga taaactccca ttaaatgata
      361 agagattaaa agatgtatgt ttagatgagg ataatatttt aaatgaaaat aatcaatact
      421 atccaagtca tatagggatt aaattttgtg aaaattacaa agaagatata gcaatgttag
      481 cagaaatagg ttttaaatgt tttagatttt ctatatcttg gtcaagaata ttcccaacag
      541 gagaagaaag tgaaccaaat gaaaagggat tacaacttta tgataatata ataaaagaat
      601 taaaaaaata taatatagag ccattaataa cgataagcca ctttgatata ccttattctc
      661 tagttgaaaa atattctggg tgggctgata gaagagtggt taatttatat gtaaaatatg
      721 ctgaaatttt gatgaaaaga tataaagatg atgtcaaata ctggattcct tttaacgaaa
      781 tgaatatgat aatgcatatt ccatatatag gtgctgggtt aacttttata gctgatgaaa
      841 atcaacttca gaaaaaatat caagcagcac accatcaatt attagctaat gcaaaaacta
      901 tagaaatagg aaggtatata aataaagaat ttaagtttgg gtgtatgtta gctgctggaa
      961 aaacatatcc atacacatgt aaaccagaag atgtatttgc aactttagag catgaaaggc
     1021 ataatttgtt tttttctgat gttcaagtta ggggtgtgta tccaagcttt atgaattatt
     1081 atttaaaatc aaatcaaata aaattaataa taaaagagga agatttatca acacttaagg
     1141 ataatactgt agattttgta tcttttagct attattctag tgcttgtagt tcagctagag
     1201 ctgaaggttt agaaaaatca aaggcaaacg gaccagaaac cataaaaaat ccatatcttc
     1261 caaaatcaaa tagtgtatgg caaaacgacc ctgtagggtt aagaataact atgaatcagt
     1321 tatatgaaag gtatcagtta cctttattta tagtagaaaa tggactgggt actcaagata
     1381 ttgtaaatga agatggaaaa ataattgatg attatcgtat agattacatg aaagaacata
     1441 ttaaaaatat gattattgga gtaaatgaag atggaataga gcttatagga tatcttatgt
     1501 ggggatgtat agatgtaacc agtgtaagtg aaggaaagat gacaaaacga tatggcataa
     1561 ttcatgttga ttctgatgac tatggaagag gctcatttaa aagaactaaa aaacaaagtg
     1621 ctttttggta taaaaaagta atagaaacag atggagaaat tttatttaat gacatggaaa
     1681 ctcatgcata attcatttta agaaaggagt gttattatga gtttaatatt tactactaag
     1741 gaccaactta tagagcaagg gtttagtaag gatacaataa aatccaatga aacgctgttt
     1801 acactagcta atggacattt aggagttaga gggaatattg aagagtctga ttttaataat
     1861 gagtatgtag ataatatggg tacatatgta aatggatttt atgaagaatc tccaattaca
     1921 tatggagaaa gcgcttatgg ctatgcaaaa caaaatcaga ctatctgtaa gttacctaat
     1981 gctcatatag taaatttctc tattgaagga gattgctttg atttatcaaa aggtattaca
     2041 agtgaacatt ctaggatact agatttaaat gaagggattc ttaaacgttc atttatatgg
     2101 gaaaactctc gtggtagaaa agttaaagta tctatagaaa gattagtatc acaagatata
     2161 gaagaattaa tgatgatttc atatacaata acaccattga attttaatgg aaaaataaaa
     2221 tttaaaaata aaatggaaaa tagtatggag aagtttaatt gtgaaaaagt agaggaccca
     2281 agagtggcat ctataaataa gaagcaattt aaaattaatg taaaaaaata taacaataag
     2341 tattttatga atttagttac agaaagaagt agattagggt tatggtgtgg gtttgattca
     2401 tatattactt gtggaaatat tacaaatgag acctataatg tttcagatga atgtattgag
     2461 cgagaaatag aagtctatgc caaaaaagat gaaaggttaa atttagaaat tgttgtaggc
     2521 tatagtagag tatattctga tttaaatcta aatgaagaac gtttaaaatc attagaatgt
     2581 ctggagtcgt taaaatgttt agaatcagaa gcacatttaa aatcattaga attggtttta
     2641 agagaagcat gtaatattgg atttgataaa gtcaaaaata ttcagagaaa gaaaatgaat
     2701 gagttttgga caacctctga tgtagagatt gaaggcgata aaactcttca actggggata
     2761 aaaaccaatt tatttcatat ttatcaatca gtaggaagag atggaaagac taatatatca
     2821 gcaaaaggtc ttacaggtga tggctatgag gggcattatt tctgggatac agaaatgtat
     2881 atattaccat tttttatata tactcaacca tccattgcca gagctttatt agattataga
     2941 tactcaatct tagatgcatc aagagaaaga gctagagaac ttggaataaa taaaggttgc
     3001 ttatattcat ggagaactat aaatggtaat gaatgcagtg catattatcc agcaggaaca
     3061 gcacagtttc atataaatgc agatatagct tatggtatta gaacgtattt tgaagcaact
     3121 aatgatgaag aatttatgat gcaaaatggc ttagaaattc ttatagaaac agcaagattt
     3181 tgggttgaat ttggagatta tatagaatca aaaaataata aattctgtat aaatggagta
     3241 acaggaccag atgaatatac agcaatagta aacaataatt actacactaa tttaatggct
     3301 aagtataatt taatatatgc agtacagatg gtagataaat ttaagcataa tttattttca
     3361 aatgaagtat ttagaaaagt taaattacaa gaatatgaag tgaaaaactg gataaatgcc
     3421 gctcaaaata tgtatttacc atatgatgaa gagaagaaaa taagcaaaca agacgattca
     3481 tttttagaaa aatcagtatg ggattttaaa aatacaccaa aagaaaaata tccattactt
     3541 cttcattatc atccattaac aatatataga tatcaagtaa ataaacaagc agatactgta
     3601 ctttcagcgt tgcttttccc tgatgagttt agcttagaac aaaagaagag agattttgaa
     3661 tactatgaaa aaataactac tcatgattca tctttgtcaa ggtcaatatt tggaatgatg
     3721 gcaagtgaaa ttggaaatca tgaaaaagct tataactatt ttatggacac agcattaatg
     3781 gatattaata acctacaaaa aaatacaagt gatggaatac atgctgctaa tatgggtgga
     3841 acatggatga gtttagtata tggatttgca ggaatgaaaa taaaaaatga taaattaagt
     3901 tttgaaccaa ggatacctaa acactggaaa aatattaaat ttaatatatt atttagagat
     3961 aatttagttt ctgtaaatat agaagaatat aaatcttatt ataagttaat caaaggtaga
     4021 aatataacca tattacatga taataaagaa ataaaattat caaagaacat aatagaagtt
     4081 aataattgtt ttaaagggag taattaatat gaaagcagtc ttatttgatc ttgatggagt
     4141 tataacagat actgctaagt atcattttga agcttggcat gagatagcaa aatcgctaga
     4201 tatagaaata gatgaaactt ttaatgaaaa attaaaaggc ataagcaggg aagaatcatt
     4261 agataaaata ttgttatctg ctaataaagt agatagttat actaaagagg aaaagttaaa
     4321 ggtgtgtgaa gaaaaaaata acatttatat aaagttaata aactcattaa catataaaga
     4381 tatattacca gggataaatg agcttataaa agaacttaaa aaaaataatg tgaaattggg
     4441 aatagcatct gctagtaaga atgcacctag gatattagaa tctttgggaa taaaagatga
     4501 atttgattgt atagtaaatc catctttatt aaaaagggga aaaccatatc ctgatatttt
     4561 tattgaaggg agcaagattc taaatttaaa acaatatgat tgtgtaggaa tagaagattc
     4621 ttattcaggt attaaagcta taaatgctgc taatatgaca tcaattggtg tggggaaaaa
     4681 agaagtacta ggaaaatgtg accatattgt agaagatact agcttattaa attacaatac
     4741 actattacaa gcttggagta aaaagattaa tttggattaa aattatatta aaaattattt
     4801 taaaagagag gataaggtat gaagaataaa tatgaagaag tagctcaatt gataattgat
     4861 ggacttggag gaaaggataa tataattgac ttaactcatt gtatgacacg attaaggttc
     4921 atcttaaaag atgaaaagaa agtcaatgca gataaattaa aatctataga taaggtagtt
     4981 ggagtaaact caacttcaac tcaatatcag gtcataatag gtaatgaggt aggtgttgta
     5041 tttaatgcaa taataaataa ggggataaat accacaggag atattaaaag cgatataaaa
     5101 aataaaaata aaaaaaatag tattttaaat aatataatag atacaataac tggttgtatg
     5161 acacctatga taccagccct tacagcatct gggatgataa aagttatatt atctctttgc
     5221 accactttta attggctatc atcaaattca agtacatata gagtattaga tataatagga
     5281 gatgtagcat tttactttat gcctataata cttgcaataa atgcagctaa aaaatttaat
     5341 gttaatacat caatagcagt tatagtagta ggtgtgtttt tacatccaaa tttctctgca
     5401 tgggtatcaa gtggggaccc tatatcattt ataggagtac caattcaaga tgttatatat
     5461 gcagcatctg ttatccctgc acttttaaca gtatggatga tgtcatatat agaaaaattc
     5521 attgataaat taacacctag catgttaaaa acaattttaa atccaacttt agtattatta
     5581 ataagtgcgc caatagcatt aatagtaatt ggaccaatag gaaatttctt aggagaggga
     5641 ttagctagta taataaattt actacaagga aggttaggat ttataatggt ttgtttatta
     5701 gcagctgcaa tgccatttat cgttatgaca gggatgcatc atgcattgac tcctatattc
     5761 atatcagcat ttgcaactac aggacaagaa tcgctaatat taatatctca agtttgtgct
     5821 aatttagcgc aaggtggcgc aacattagct gtagcattaa gaagcaaaga tagtaagatg
     5881 aaacagttag catcagctgc atggatatca gctatcatgg gtataactga accagctctt
     5941 tatggagtta cattgaaact taaaaaacct gctatgttag catctatagg agcaggaatc
     6001 gcagggttat ttgcaggaat tactcatgtg actttatatg ttccacaaaa tagtataatg
     6061 gcagtacttg gattatcagg ggaaaagggg atttcaaata tagtaaatgg acttatagtt
     6121 atatttatag cattggttgc tccatttatt atgacatatg tttttggagt tgaaaaaaat
     6181 gttaaataaa gtacagataa tgtagtagag gaagtataat attaactatt tacattaata
     6241 gaatttttat tattattgac tataacttgt tttgtattta tattgatgca aagaaataag
     6301 ttaatattaa taagaataat tattagaact gacaaaaagc aacataaaag attgatgaag
     6361 tatatggaaa taaaaagttg acaaaatatg tctgatgttt tatcatatta attggaatta
     6421 ggtagtaatt gtttaagtac aagctaagct tattcattaa taatagcagt atcctaggaa
     6481 ggagtatgcc cattattatg gataagcttt ttttatgctt aaaaggagga taatcatgat
     6541 aattaataag atattaaaca ataatgttgt aatcacatta gatgataatg atgaagaagt
     6601 tatcgttatg ggtaaaggaa ttggttatca aaaatcaaaa ggcaatctaa tagataaaac
     6661 taaagtaaat aaagtattta gaatatcaaa taaagaaata tcaaacaaac tacaagaatt
     6721 actcaataat attcctatag aacacatgaa attatcaagt gaaattatag aatacgcaca
     6781 aataaagtta aacaagaagc taaatgaaag tatttacata tccttaagtg accatacata
     6841 ttctgcaatt caaaggatga aagaaggaat aaatgtaaaa aatgcaatcc tttgggaaat
     6901 taaaagattt tataaagaag agtttgaaat tggaatgaaa gcactagata ttattgaaaa
     6961 caaaacaggt ataaaattac cagaagatga ggctggattt atagcctttc atatagtgaa
     7021 tgctcagtta agtgaaggtc atactttggc atctgatatt acgaagttaa tacaagaagt
     7081 acttagcata gttaggtatc attttaggat agaatttcat gaagaatcag tgttttatta
     7141 tagatttata atgcatttaa agttttttgc gcaaagattg cttttagata gtgcacatga
     7201 aggtgagaca gacaaagaat tactaagcat tattaaatct aaatataata aagagtttga
     7261 atgtgtagtt aaaattaaaa atttcattaa aaaacaatat aactacatat taacagatga
     7321 tgagcttata tatttaacaa tacatttagc taaagtagtt aaagactcaa atatgtaagt
     7381 gaaataattt ttcagtagta tattaagaat gattgaaagg agtgatacta acaaaattat
     7441 acttatggtt ggatggtaac attgagttgg ccaaaccttc aaatttcaaa aaattaattt
     7501 aaacgaaata tggaggagaa aaatgggaaa atacaaacaa ttagcacaag agatagtaaa
     7561 caatgttggt ggaaaagaaa atattagtgg gttagtacac tgtattacaa gattacgttt
     7621 tactttaaaa gatgaaagta tagcaaatga caatgtatta aaaaacatgg aaggtattgt
     7681 tactgtaatg aaaagtggag gacaatatca agtagttata ggaaatcatg ttgaagctgt
     7741 ctataaagat gtagttgaaa taattggttt agatgattca agtacaagtt cagaaactaa
     7801 aaaatcaggt aatatactag ataaaggtat agatataata tcaggaattt ttcagccagt
     7861 gttaggaata atggcagctt gtggtatgtt gaaaggattt aatgcattat ttgtagcaat
     7921 gggattatat agtgatgtat ctggtggtta tatggtaata aatgcagcag gagatgcatt
     7981 atttacattc cttcctttgt tcttaggata tacttcagct aagaagtttg gattaaaacc
     8041 aatgttggga ttagcactag gagctgcagt atgttatcct gctatacaag gtagcagtat
     8101 atcagcagga gcagatgtga tgtacacttt atttaaagga acaatgtttg catcaccagt
     8161 atatattgat ttctttggac taccaattgt atcaattgat tatactggaa cagtcgtacc
     8221 aattatattt atagtgtatt ttgcttctag gtgtgaaaaa ttatttaata agtgtgttcc
     8281 aaatttagtt aagtttttct ttgtgccaat gcttacatta ttaataacag tgcctgttgc
     8341 acttatagtt ataggcccta tagcaacatt tggttctaca cttatttcac aaattgtaat
     8401 ttcaataaga gattttagtc cactattggc aggtgctata gtaggattta cttggcaaat
     8461 tcttgttatt tttggtatgc actggggatt tattcctgta tatataaaca atgttatgac
     8521 tttaggatat gataatgtta tgatgccatt ctttgcctgt acatttgcaa gttcggcagt
     8581 tgtgttggca atatttttca agactaaaga taaaaaacta aaagagatgg caataccaaa
     8641 ctttatatct ggtatatttg gagttacaga gccagcaatt tatggaatat tattgccttt
     8701 aaagaaacca tttataataa gttgtattgc tagtggtatt ggaggcgctt tctatggatt
     8761 ctttaatctt agaaaattta taactggagg aatgggaata tttgaacttc cagcaatgat
     8821 tgaaccagat gggggaatgg gtaacttaat agtagctctt tctggtatag ctatatcaat
     8881 ggtcgtagct tttgtattaa ctatgatttt atataaagat gagaaagtag aagagtctaa
     8941 aaaagtaaga aataagggta aagaagaaat aaaagaagtc aagtctacta aattagaaag
     9001 agaaatagta acaagtccta taaaaggtga agtattaaaa ttaagtgata tagaggatgc
     9061 agcatttgca tctggtgtac taggtcaagg ggtggcaata atacctagtg atggaaaagt
     9121 agttgctcca gtagatgggg tagttacaac cttatttcct agtctacatg ctatagggat
     9181 tctttctgat acaggtgttg aagtgcttat tcatattgga ttaaatacta ttcaattaga
     9241 gggaagaggt tttgaggcat gtataaaaca aggtgataga attacaaaag gtcaaactat
     9301 attaaacttt gatgtttatg caataaaaga gttggggtat agtactgtaa ctccaattgt
     9361 tattacaaat tcatcacaat ttttagatgt agtagaaaca gaaagtaaaa atattgaatt
     9421 agaagacaat ctaattacag tcttatttta gtaaagattg aggtattagc ataatctagt
     9481 gctttggtta taattttagg aggctttgac tatgagtttt aagaatgatt ttttatgggg
     9541 aggagctact gcggccaatc aatgtgaagg tggatacaat gaagacgaaa gaggattggc
     9601 aaatgtagat gtatgtccaa caggaaaaga tagaacagca gttattacag ggaaactaaa
     9661 aatgtttgat tttgatgatg agcattatta tccagctaaa actggtattg atatgtatca
     9721 taattataaa gaagatataa agttatttgc tgaaatggga tttaaagtat atagaatgag
     9781 cattgcatgg agtcgaatat ttccaaaagg tgatgaagaa acaccaaatg aaaagggact
     9841 tcaattttat gaaaatatat ttaaggagtg taaaaaatat aaaatagagc ctttagtcac
     9901 tattacacac tttgattgtc caatgcattt agttaaaaag tatggtgcat ggcgtaatcg
     9961 aaaaatgata ggtttctatg agaaattatg caatgttatc tttagaagat ataaaggatt
    10021 agtgaagtac tggctaactt tcaatgaaat aaatatgatt ttacatgctc catttatggg
    10081 tgctggtatt tgctttgaag aaggtgaaga tgttgaaaag ataaaatatc aagctgccca
    10141 tcatgagctt gtagctagtg caattgcaac taaaatagca catgaagttg attcaaataa
    10201 cttaattgga tgtatgtttg cagctggaag tgtatatcct tatagttgta atcctaatga
    10261 tgtatgggaa gctacaaagt tagatagaga aaattacttc tttgtggatg tacaatctaa
    10321 aggtaaatat cctaactatg cgttaaagta tatggagcaa aaaggtatta caccagaaat
    10381 ggaacctggt gatattgaat tattgaataa atatacagta gattttattt cattttcata
    10441 ttacaatagc cgttgtgtta gaaccgatga aaatgcagat gatatggctg aaggaaacat
    10501 atttacatct gctaaaaatc catatctttc atacagtcaa tggggatggc caattgaccc
    10561 attaggtttg agaattacac taaatcatgt atatgataga tatgaaaagc cactatttat
    10621 tgtagaaaat ggattaggtg ctaaagatat agctgatgaa aatggttatg tagaagatga
    10681 ttacagaatt gattatctaa gagaacatat aaaagctatg catgatgcag tttctataga
    10741 tggggtcgat ttattaggtt atactacatg ggcacctatt gatttagtaa gtgctggtac
    10801 aggtgaaatg gaaaagcgtt atggatttat atatgtagat agagacaata gtggtaatgg
    10861 aagtctaaga agaatgaaaa agaaaagttt tgaatggtat aagaaagtaa ttgcttcaaa
    10921 tggtgaagat ttatattaga caagaaatct atgttaaata agaaatctat attagacaag
    10981 aaatctatgt taaataagaa ctttgtatta aataagaaga gtataaaaat taataataag
    11041 tataattttt aactttttta actatagaaa atcaatatag aattatttta cattgtattg
    11101 atgcaatagt atgattcaca aataaaattt tagaaaataa aattgttaag aagtatggga
    11161 agtaagtgca atttactttg taataaaaga tgaaaaaggc aagcttaggt tttaagcttg
    11221 tcttttttat tatgtataaa ctatgatatt ttaaaattct atgaaaaatt tatttaatag
    11281 agaaattaaa aatttaatgg taatcaaatt ctttaccaat gaatataaaa aatgtctacg
    11341 tgttataata gtttaaacta ataaacgaaa ggtagatgaa tgaatatgaa ataccaacat
    11401 ataatagaag ttgacaaaga actttgcatt ggatgtgggc tttgtaaaaa tgattgtcca
    11461 gtaaacaata taattataga aaataaaaag tcagtaatta aaaaacaaga ttgtctaatg
    11521 tgtggacatt gtgcagcaat atgtcccaca aaagctatta ccttgacagg atttgatgaa
    11581 cctcctatag aacttacaaa taagccaaag ctagattcag atgaattact aatggcaatt
    11641 aaatctagaa gaagtatacg taaatttaaa gataaagaag tttcttcaga aattataaag
    11701 caaattattg aggcaggtag gtatacccct agtgctaaaa attcacaaga tgtatcatat
    11761 attgttttag acaataaaaa gtcaatttat gaaaacgaag cagtgaaatt ttttagaaaa
    11821 ataaaaccta ttgcaaatat agctattaaa tattcaaaag aagttgagat tgacgataac
    11881 tttttcttta agcatgctcc tattgcaata atgataatta caaaagataa gattagtggt
    11941 tcacttgcag catcaaatat ggcattaatg gcagagtctt atggtctagg tgttttattt
    12001 agtggatatt tttcagatgt agcaaataat tcgccaaaat taaaaaagct tttaggtcta
    12061 aaacgtagta atcatgttct tacaacatta gtaattggat acccagatgt taaatataga
    12121 cgtactgcac agaaagaagt agcaactgtt agatacttat aagagagggt ggattttatg
    12181 gaaaaagaat gtcaacaaag aatgcaagaa ataacgtcta aatttaaaga atgtcgcaaa
    12241 gctatctctg ctatgggtga tgagactaga caattgattt taattgctct tttagagagt
    12301 gattttaatg gtatacgagt gggagaaatc acaaaaaaaa cacatctttc tcgtcctgct
    12361 gtatctcatc atcttaagat attaaaagaa gcagagattg ttaatttgcg tagagaagga
    12421 acgaaaaatt attattatct tgattcaaaa aaatcacaat ggaagtcact aacagagcta
    12481 ataaatctta tatttgttgg aatacaacat attagtgaaa atgatataag aaaaggtgat
    12541 taaattatac ttgatttaat acaaaaagat tgatttagga actaaaaaat tcactttgag
    12601 acactatctt ttgaactata cccattttag gagacggtta aaatatgtaa aactgtataa
    12661 aacaatgggt atagttcatt ttataatggt ttaaatatta agaatatatt attctaaata
    12721 gtatctttct ctgttttgag ttttattttt atactcaata gcttcagtgg ggcaaccaca
    12781 aatacatgcc atacaatgag tacagttatt tttccaaact ggttttttgt tttttaaatt
    12841 aatattattt aaaggacata gctctacaca ttttccacag ccaatgcatt tatcagtata
    12901 atgaaatcct ttggcactaa taattgtctt ataaaaaact gtatttatta taccactttt
    12961 aattgtacct cctaagccac taggagtaat agtttcaaat tcattttcat tgcgtatatc
    13021 agaaataatc ctatatattt gtttatctgc ttctttaatc atttgttttg atgtttcttt
    13081 gtctgttgta gaaaataaag ctatataatt ctctggcatt ttaatttctg ccataccttt
    13141 taattgccat tccttgtatt tacatagttt ttgaatatag tttatggatt ttgctgtatc
    13201 tccaccacaa gtcattacaa agtaaactct gttgcttcct agaaattttg tttcttttat
    13261 aaaatccgta actactattg gcaatctcca tgcataagta ggacatacaa atatgaatgg
    13321 tttatctgct gatattaatt catctgtttt ttcctctttt ataagttgat ttagtgatat
    13381 cagttcatca tttaattctt gtgcaatttt acgagccaca tatcggctat taccagttcc
    13441 gctaaaatat aaaatcataa taatatctcc ctaactattt tttatttatt atagtaattt
    13501 attgatatat tctattcaaa tgtatgtaaa atttagtagt taagaaaatt ataacacatt
    13561 agtaattttt atacttattg gtaaagaatt tgattaccat taaatttagc aacaagacat
    13621 caactggact tgtatatgag aagggataat aatttgctta tgaaagatta taaatataaa
    13681 ggttatttta aaggtgtaga aatatttgat aatgtaaatg accttaactt aaatacttta
    13741 acaacagtta gtagatttgt gcttgttttt ttgtttacga taacttaagg aaatatgtta
    13801 cctgaataat aaatttatat aataaaagta tataaatata tatatgaatg ttaagattag
    13861 ttgatagaat ttaaataata aatccaatat tataaacata ggaggtatga aaaatatgat
    13921 taatgagaat ttaaaaagtc taagaaaaat caaccagtat acacaagaag aattagctga
    13981 aaaacttaat gtttctagac aatcaatagc aaaatgggaa agtggagaat ctattcctga
    14041 tatatgtagt tgcattaaac ttgcaaaatt gtacaatgtc aaactagatg acttagttaa
    14101 tcattcagaa gaaaaaacag gtattatagt acctcctaaa ggaaagtttt tctttggagc
    14161 agttgtagtt ggtgaacgtg gtcagattgt cattccaaaa gaagcaagag aagtatttaa
    14221 tataaatgca ggagataaat tattggtact tggagatgag gaaagaggat taggaattgt
    14281 tcatcaacgt gatttgataa attttatagg tcatgtggga gtagtacgta aagaagaatg
    14341 atttaaaaaa attataaaag gaggtatgaa atatgagtaa aatagtattt tttagcattc
    14401 ctgcatatgg tcatactaat cctactattg aagtagttcg tgaattagtg gatagaggaa
    14461 atgaggtatt gtattattct tttaatgaat ttaaagataa aattgaaggt gctggagcaa
    14521 aatttatttg ttgtgataaa taccttccag aattactccc tggagatgag aaaaaaattg
    14581 gtaaggattt tcctggatta attgagatga tagtagatac tactatttct ttagatgaaa
    14641 aagtttgtag agaacttaaa gattttaatc cagattgcat tgtatcagat tcattaagtt
    14701 tttggggaaa gttatttgca caaaaactta atattccata tgtatgctct acaacaactt
    14761 ttgcatttaa taaacataca gcaaagttga tgaaacaaaa ctttatagaa attatacgta
    14821 tgatttttgg tgtaagacgc attaataaaa aaataaagct tttacaaaga aaagggtatg
    14881 aagtaaaaaa ttttatttct atagtttcta atgataatga tacggatacc attgtatata
    14941 catcaaaaga atttcaacca atggtagaaa ccttctctag taagtattca tttgtaggtc
    15001 catcagtatc aaagttgatt attgaaccta aagagagaaa aagaaagcta atatatattt
    15061 cgcttggtac aattaataat aaaaatgtta gcttttataa aaactgtata agtgcattta
    15121 aagattctga tgttgatgtg attatgtctg ttggtagaag tactgatatt aaaagtttag
    15181 gaaatatacc aaataatttt gaggtcaaaa atagtgttga acagattgct atacttcaaa
    15241 aaactgatgt gtttgttact cattctggga tgaatagtgt taatgaaagt ttatattatg
    15301 gagtacctat ggtattattt cctcaacatt cggagcagag aatggtagct aagagagttg
    15361 ttcatttggg agcaggaatt atgttaaaag aggataagtc agaaagtatt aaaaaagcag
    15421 tatttcaagt tataaatgac aatgaatata aagaaaatgc aactaaacta tcaaaaagct
    15481 tttataatgc aggaggctca aaaaaagcag cagatgtaat attacagatt atatgtaata
    15541 gtagacaagt tgacatataa tagatttgtt aaaaatatat atacatacat gtaatttaat
    15601 caaagtactg acagtggggt cttttaacct accagttggg gcatatatat tgatgctaaa
    15661 tatgagggat gttatatttt aataaaaaag ataacatcct ttttttagtg cattatatcg
    15721 agttttaaat aataaatgaa ggaggattaa tatgaaaaaa tataaagtta tttttatagt
    15781 attaattata ggtattataa gtgtaacagg gtttgttgta tataaaaact gcattaaacc
    15841 atggaaagat gctgaaacat atattgataa gtatatggta aaacaagata tttcaaaaga
    15901 taatataaaa agtattacaa aagaaaaagc caagaaggca agttacgaag gaatactata
    15961 caaagtgtat tacaaagatg accctcgata tgagtatcaa tatttttata gtgataatta
    16021 ttatgctcta tatgtaaata aagtaatgtt acaaatttat gatatggaaa ataataataa
    16081 acttttaaga agtaatgagg aattaaaaag tgtaaagtat ccactaatat atcttaaata
    16141 taagccagat aaatgattta tgacaaaata gaatgatttt tattaaaatt tatttaaaaa
    16201 tatcactag
//
LOCUS       DAEPID010000085        15756 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.085, whole genome shotgun sequence.
ACCESSION   DAEPID010000085 DAEPID010000000
VERSION     DAEPID010000085.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 15756)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 15756)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..15756
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.085"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            complement(338..718)
                     /locus_tag="KR257_003120"
     CDS             complement(338..718)
                     /locus_tag="KR257_003120"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426829.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="BlaI/MecI/CopY family transcriptional regulator"
                     /protein_id="HBH0031791.1"
                     /translation="MCLKKLSKLELVIMKFIWNLDIKTNSYEIIDYMKEEHNLPEKVA
                     LKTLSKLSKKRFLYVQETGKCMYYTVAIKEKAYLEFISRNVQNLLKNNFIRNLLVSFH
                     EEELTEEKIKSLENWVVNWEEAYV"
     gene            complement(919..2112)
                     /locus_tag="KR257_003121"
     CDS             complement(919..2112)
                     /locus_tag="KR257_003121"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895690.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cation:proton antiporter"
                     /protein_id="HBH0031792.1"
                     /translation="MLTSLALIFLLGMASGGIFKRIKLPNLLGMLLTGIILGPYVLNL
                     IDNSILDISSDLRKIALIIILTRAGLSLDINDLKKVGRPAVLMCFIPATFEIIGMIVL
                     APKLLGVSILEAAVMGAVVGAVSPAIIVPKMLKLMEEGYGTEKSIPQMLLAGTSIDDI
                     FVIVMFTVFTGLAQGNSISAISFLQIPVSIILGVIVGAVIGIYLAVFFKKVHMRDSAK
                     GVLLLSISFLMISLETALEGIVPFSGLLAVMSIGIFLQIKYRVVARRLSIKYSKLWVG
                     AEILLFVLVGATVDISYAFKAGIGAVILIFGVLLFRMVGVFFCLIKTNLTIKERLFCM
                     IGYIPKATVQAAIGGVPLAMGMASGQLILTLAVLAILITAPLGAFGIDVTYKKLLTSV
                     KGENK"
     gene            complement(2175..3431)
                     /locus_tag="KR257_003122"
     CDS             complement(2175..3431)
                     /locus_tag="KR257_003122"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426825.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="chloride channel protein"
                     /protein_id="HBH0031793.1"
                     /translation="MIEKFKTLIWIKMIIRIKSVYKTYGGLFFLGLIGIPVGAIIGLI
                     DTIFGTVLLKVTDIRETYPMYLIPFLAVVGVVIAYCYFKFGGKSSKGMNLIFEVGHGE
                     EEIIPLRLVPFIISGTWLTHLFGGSAGREGVAVQIGATFSHWVGKRLPIKNASSIFLV
                     TGMAAGFAGLFETPIAAILFAMEVLVAGSLEYQSLFPAFTASFTASAVSKALGLEKFS
                     FALSSKVVFDLSIFWKLIVLGIIFGMVGGAFAWCLKLSKRKIGNRLKNPMIRIAIIGV
                     CLSVLFLLFYKGRYSGLGTNLIQNSFYGGEIYSFDWLLKFILTILTLSAGFQGGEVTP
                     LFSIGASLGVLLAGFFNLPIELVAALGYASVFGSATNTFFAPVFIGAEVFGYSYLPYF
                     FVVCAISYIFNMDKSIYSLQKISTKQ"
     gene            complement(4227..4961)
                     /locus_tag="KR257_003123"
     CDS             complement(4227..4961)
                     /locus_tag="KR257_003123"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728665.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MBL fold metallo-hydrolase"
                     /protein_id="HBH0031794.1"
                     /translation="MNLAKGLDVLKISSNVFGEDKVMYIPVIYTEDDATLIDTGLPGQ
                     GDLIIDALNKSNTSFDKLKNIIITHHDIDHIGNINYLREKSKNNIKVYAYKSEISYIT
                     GEETPFKLYMLEQMVDKIDDKMLSMLNVMGLGFKSSYTKVDVSLDNHEKLNLGEEIEV
                     IHTGGHTRGHICLYLKESKVLIAGDLLQVENGELKPVDVMYSNKQELKDAIKNISNYD
                     IETIVFSHGGLYQRNIIGTLKNLIIE"
     gene            complement(5967..6605)
                     /locus_tag="KR257_003124"
     CDS             complement(5967..6605)
                     /locus_tag="KR257_003124"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003440185.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC-2 transporter permease"
                     /protein_id="HBH0031795.1"
                     /translation="MLIHLVKKDILIVKKYVLLILFIAIGIPLFILWRLPPFAQILGF
                     VLSIIFSEFMLCQYLLLKESQYSKASVLLCSTPYPRRGLVQSKYVLFAMVFIYCTLVY
                     WIENLLIPQIGTFDLTYILIVLLISSIIYGVYMPIQYKLGYETTKFFFVMIIMASSFV
                     LPLTIAHSNFEIPFIYQYPSMIVNIVLFLLSLIILLASMFISIKIFSNKELV"
     gene            complement(6608..7465)
                     /locus_tag="KR257_003125"
     CDS             complement(6608..7465)
                     /locus_tag="KR257_003125"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860900.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBH0031796.1"
                     /translation="MENILEVYNLNKTYTDFSLSNISFALPEDCITGFIGVNGAGKTT
                     TIRSILDVVKRDSGKIKIFGKDFDGNEKELKNRIGVVFDDSYFYEELSMAEMKSIIAP
                     SYDNWCEEDYQQNMKRFNLNPKQKIDTLSKGMKMKFALALALSHKAEFLIMDEPTSGL
                     DPLIRSQILDILTGYMKKCGRGVFFSTHITSDLDKIADMIVMIDNGRIILEREKDTLL
                     DEHRKVKGDIQFLNDETKKLFLNLEITGYGFIGITSKINEVQKNMPDILIERPTIEDI
                     MLAYIERRE"
     gene            complement(7467..7841)
                     /locus_tag="KR257_003126"
     CDS             complement(7467..7841)
                     /locus_tag="KR257_003126"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888433.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GntR family transcriptional regulator"
                     /protein_id="HBH0031797.1"
                     /translation="MKVLISNTSDKPLYQQIKEQIKEAIFTEELKEGDAMPSIRNFAN
                     DLKVSILTIRRVYEELENEGFLTRQVGIGTFISTGNLEILRDSKRRIVEQKMADMIKD
                     AKALGITQIELQEMMDILYEED"
     gene            complement(8990..10180)
                     /locus_tag="KR257_003127"
     CDS             complement(8990..10180)
                     /locus_tag="KR257_003127"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860897.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="permease"
                     /protein_id="HBH0031798.1"
                     /translation="MSDMLLWFSVVLVLFAIGDLIASKTKAKVSAVFVTLLLFLILFV
                     TKAIPADIIEKAGMTAAASWSVPMIMFSMGTMLNVKQFIDEWRTVLTAWLGIVAVIVC
                     VSLCIPLFGKSTVLTSIPVINGALPATTIMTQAALEKGLTLAAATATVVFAIQKFIGT
                     PIASRAALQEANRLLVEYHEAKSKGIDLANVDTDKKEAENTGTKVKQAFCEKYDKYYS
                     TNVCIFFIALFSYLGYELSEIIHVNYSIVCLVVGVIVTRIGIVPKDILEKGKIKGFIN
                     MVVFAAVIPSLAKVSLTDLISLFVPIVGMFAASIIGIFLMMKVLPGWKIIGSKPLAFG
                     VGFCQMLGFPTTYLISNEVCNAVGETEEERAYLMSKIMPKLVVGGMACMISIVVAGLM
                     VPML"
     gene            complement(10196..12151)
                     /locus_tag="KR257_003128"
     CDS             complement(10196..12151)
                     /locus_tag="KR257_003128"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895678.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="S9 family peptidase"
                     /protein_id="HBH0031799.1"
                     /translation="MEKIKIENSDIFEYIFPHDISCSPDGKHIAYIISNINEEKDCYE
                     HDLYVMDIKTEKQIHMTQTKDVTSFSWISNTELLFTSKRNKPKSGTTDFYTISIEGGE
                     AKKAFSIPKACSVPVSLGNKLWLLTTKNPTDSKKSEPDRAVEGVDYWTFTDKPFIRDG
                     ENFSQRRRVTLELYQEGENITKAITPKFCEVAGVDVSSDKNRILYTGQIYEDCATPFS
                     GLWEYHIDSGETKELVPQGKYQISLAKYIGKDKVMLQASTLDRSITQNHDIFILDLST
                     NEINMIASPDGMYATLLDVDAVYGGGRSNKVIGDKFIGARICRTMTEFNEFDTKTGNI
                     RIITKVDAFTSFDIYDNTMYTVMLKDYELAEIYSIDMTTGTMKKMTAFSKPYLDTHKV
                     SLPEKLTFVAKNKEEVDGFVIPPIDAKEGEKYPAVLFIHGGPKWAYGYMFTHLKQCVT
                     SKGMYVIYCNPHGGDGYGEKFLEMVERWGYVDYEHLMEFVDTCIEKYPGIDADRLGVA
                     GGSYGGYMTNWIIGHTDRFKAAVSQRGISNLITASLIIDFGDRIMKQTCGDKTPWNHE
                     EVLWNHSPIKYVKNVKTPTLFLHSDRDYRCFMGDTFQMFTALKQLGVDTEMYLFHGDT
                     HGLSRNGRPSNRIARANAIVDWFERYL"
     gene            complement(12168..14234)
                     /locus_tag="KR257_003129"
     CDS             complement(12168..14234)
                     /locus_tag="KR257_003129"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003440170.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="S9 family peptidase"
                     /protein_id="HBH0031800.1"
                     /translation="MKEVVESLKKITKERIENTMKKLFTSETFLEYQFISDCQISPDG
                     GYTAFIVKKADIKENGYTSQVYILNNKTGELKQITSINSVGAYAWEDENTILFPALRN
                     EKVKEAVKNGKQCMSYYALSLNGGEAEELFRLPIKGGKLNPIGKGLYAVIDSYDNDRP
                     IVEGLPEEEQQKKINAYNKRHYEHFKEIPYAVNGEGYISRKRKRLYVYDSNINELKAI
                     TAPMFNVVGMKISDGKILYIGQEFKDVKGLKNGVYVFDTNTNTNVCILEKDKYIIKGF
                     ELYQNQVILNLTDALSYGNGENGDFYTIDIDTKEMKLLSGHQHHCIGNTVTSDVKMGA
                     GQTTKVDGEYIYYTSTVDMDCIIERIHIPTGKQEKVTQTGSVDFIDVKDGNIVCVGCL
                     GNGLPEVYTVENGTLCKKTHLNDHILEEYKISVPEYIESKGSSKWEIQGYVYKPVDYE
                     VGKKYPAVLAIHGGPRLTYGPYFMHEIQVFTSAGYFVFFCNPRGSEGRGNAFADIRKQ
                     FGDIDYIDFMEFTDTVLEKYTDIDKTKLAVEGGSYGGFMTNWIIGHTNRFAVACAQRS
                     IANWSGMEGTTDIGYYFCKGQTGASHMENHELQWKQSPLAYADKCVTPTLFLHGEKDY
                     RCYMQEAFQMFSALKIHGCPTKLCLFEGENHELSRSGRPKQKLQRLVEMLDWFSVYIK
                     KDNIGQ"
     gene            complement(14561..15211)
                     /locus_tag="KR257_003130"
     CDS             complement(14561..15211)
                     /locus_tag="KR257_003130"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009905011.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GntR family transcriptional regulator"
                     /protein_id="HBH0031801.1"
                     /translation="MKVKSNLDEILYHKIIESLIRGEYSVGQKILLNDLCEKFEVSRT
                     PVVQAVKMLNKDGVLTIMTNGKVYVPEYEYDMVKQVCETRTLIETYALEKMMQEEEEV
                     FQQKLDVIKRYSDKCEEYYRQEKSVELALADLELHKAIVEGANNEILNDVYVGIQGRF
                     IVVNYLIRPLKNRNYEGTVQDHFEILKFIEDRDTKKAVDKLRNHIQGTIKRFCEDE"
BASE COUNT         5436 a         2768 c         1753 g         5799 t
ORIGIN      
        1 taatattttt tattattttt ttaacaaact atcagagtag aattatttaa tattttgtta
       61 tttttaatca aatgaacgaa tattatatat atcattcata aaaactttat ataaagaata
      121 gaaacaagtt ctagattact atagagatga catatcaaaa tatttttaaa aagcaattta
      181 agtattagaa gtaattgaag ttagtaaata taaatgcgtt tacttttaag tattgcttaa
      241 gggaataaaa aataaaaata aactctgcaa ccatctaaaa atagttgcag agcttacaaa
      301 accaaaatta tctaaattgt aataaaaata ataacattta tacataagct tcttcccaat
      361 ttactaccca gttttctaac gactttatct tttcctctgt tagctcctct tcgtgaaatg
      421 atactaataa attccttata aaattattct tcaaaagatt ttgcacattt cttgatataa
      481 actctaaata tgccttttct ttgattgcaa ctgtataata catacacttg cctgtttctt
      541 gaacatataa gaatcttttc tttgatagtt ttgataaagt ttttaaagct actttttctg
      601 gtaaattatg ttcttctttc atataatcaa taatctcata tgaattggtt tttatatcta
      661 aattccaaat aaatttcata ataactaact ctaattttga taattttttt aaacacatag
      721 ttatcactcc gcttctttat ctatataatt aaatattaca ataataattt cacaaaatca
      781 attctaataa tcataacata ccttaaaatc tgttcttaac ttctaccttc ttaatctccc
      841 aaatgatttt tttatattgt attcaatagt ataatccttt tccaaaatat aacttaccag
      901 ttaaaataat ctttattttt acttattctc gccttttaca gaagttaata attttttata
      961 agttacatca attccaaaag ctccaagagg tgcagttata agtatagcta gaactgctaa
     1021 cgtcaaaata agttgtccag atgccatccc cattgcaagt ggtacacctc ctattgccgc
     1081 ctgtactgta gcctttggaa tatagccaat catacagaac aatctttcct ttattgtcaa
     1141 atttgtctta ataaggcaga agaatactcc taccatacgg aataaaagaa ctccaaatat
     1201 taaaattaca gctccaattc ctgctttaaa tgcataactt atatctactg ttgcccctac
     1261 caaaacaaac aagagaattt cagcaccaac ccatagtttc gaatacttta tagacaatct
     1321 tcttgcaact acacgatatt ttatctgaag gaaaatccca atactcataa ctgctaataa
     1381 tccagaaaat ggcacaatac cctctaaagc agtctctaaa cttatcatta aaaatgagat
     1441 acttaaaagc aacacccctt tagcagaatc tctcatatga accttcttaa aaaatactgc
     1501 taaatagatt ccaatcactg ctccaactat tacacctaat ataattgata ctggaatttg
     1561 taaaaagcta atagctgata tactatttcc ttgtgccaat cctgtgaata ctgtaaacat
     1621 cacaattacg aaaatatcgt ctatagaagt tcctgctaaa agcatctgtg gaatactttt
     1681 ttctgtacca taaccttctt ccattaattt aagcatttta ggtacaataa ttgcgggaga
     1741 aactgctcct actactgcac ccatgactgc tgcttccaat atagaaacgc ctagtaactt
     1801 tggtgctaaa actatcattc cgataatttc aaaagtagct ggaataaagc acataagtac
     1861 agcgggtctt cccactttct tcaaatcgtt tatatctaaa gataatccag cccttgttaa
     1921 tataataatc aatgcaatct ttctaaggtc agaagaaata tctagtattg aattatcaat
     1981 caaatttaaa acatatggac ctaatataat tcccgtaagt aacattccca ataagttagg
     2041 taattttatc ctcttaaaaa tacctcccga ggccattcct aataaaaaaa tcaaagctaa
     2101 acttgtcaac atattcctac cctatccttt ctctaatatt ctttctcttc taatcataca
     2161 ttatgttgtt ttatttattg ttttgttgaa attttttgta gtgaataaat agatttatcc
     2221 atattaaata tatatgaaat agcgcatact acaaagaaat aaggtaaata gctgtaccca
     2281 aaaacttctg cccctataaa tacaggtgca aaaaaagtat ttgtagcact accaaagaca
     2341 ctagcatagc caagcgctgc aactaattca attggcaaat taaaaaatcc tgctaacaat
     2401 acaccaagac tagctccaat ggaaaacaaa ggtgtaacct ctcctccttg aaaacctgct
     2461 gacaaagtca gtattgtaag tataaacttt aacagccagt caaatgaata aatttctcca
     2521 ccatagaaac tattttgaat taaatttgtc cctaaacctg aatatcttcc tttataaaat
     2581 aaaaggaata atacactaag acatactcca ataatagcaa tccttatcat aggatttttt
     2641 aatctattcc ctatttttct ttttgacaat ttcagacacc atgcaaatgc tccaccaacc
     2701 attccaaaaa taattcctaa aacaataagc ttccaaaata ttgacaagtc aaatacaact
     2761 ttagaagaaa gtgcaaaaga aaatttctct aaccctaaag cttttgatac tgcacttgct
     2821 gtaaaagaag cagtaaacgc aggaaaaagc gattgatact ccagtgaacc agcaaccaaa
     2881 acctccatag caaatagtat tgctgctatt ggtgtctcaa ataatcctgc aaaaccagct
     2941 gccataccag ttactagaaa aatactagaa gcatttttta taggcaacct tttacctacc
     3001 caatgtgaaa aagttgcacc aatctgaaca gcaactcctt ctcgtcctgc actaccacca
     3061 aataaatggg ttaaccatgt acctgatatt ataaatggaa ccaatcttaa aggaataatt
     3121 tcttcttctc catgccctac ctcaaatatt agattcattc ctttactact ttttcctcca
     3181 aatttaaaat agcaataagc aataacaact cctactactg ctaaaaatgg tatcagatac
     3241 attggatatg tttctcgaat atctgtaact tttagaagaa ccgttccaaa tatggtatct
     3301 ataagaccta taattgcacc aactggtata cctatgagtc ctaaaaaaaa tagtccacca
     3361 tatgttttat aaacgctttt aattcttatt atcattttaa tccatattaa agttttaaat
     3421 ttttctatca ttttaattcc tttctatttg catcataaga ttttttgaaa gttttattac
     3481 atcaactgta gtcaatgtaa tgactatcat aattgttttt taaattgata ggatataggt
     3541 acactcttaa cccattctta ataaaataat taacatataa tctactattt tttctattaa
     3601 ttaaatattt cttcaaattt aaaaaataaa aatttagtaa gtacttcacc tccattttat
     3661 cgatttaaac aacaaaaaaa gctggtggca tctatgatat catagaagtc atcagctcat
     3721 tggcagttta ggatattatc atccaaggga gaacctcatt cccataatta ttatataatt
     3781 ttttattttt catatgtcta ttttatgtaa attgtatttt taatgttata aataatataa
     3841 cctatcaatt aaaatattaa agtctctaat attatgagtg ttcaatactt catattattt
     3901 ttatgatata taatttaaat gattttcttt actttgcatt atgatacatg atttaaatat
     3961 ttttcttcac tttgtatact aaagtttatt taaaatattt tctttcctat tatactatgc
     4021 tgttaaatat ttttcaactg aagtattgta gaactttaaa attactataa aaaattatat
     4081 tctaaaatac ttgtaatact acatatcacc cttaacactt aagtataatt ttaaagcaaa
     4141 attcttatta cttatattta attttgattc tacatcttta gatataattt taagtaattt
     4201 aagaaattat tgtaaatcat atagtactac tcaataatta ggtttttcaa tgttccaatt
     4261 atgtttcttt gatataatcc accatgacta aaaactatcg tttctatatc ataattactt
     4321 atatttttaa tagcatcttt taactcttgt ttgttgctgt acatcacatc aacaggctta
     4381 agttctccat tttctacctg taacaaatct ccagcaataa gtactttaga ctcttttaaa
     4441 taaagacata tgtgacctct agtgtgacct cctgtatgta taacttctat ttcctcacct
     4501 agattcaatt tttcatggtt atctaatgac acatctactt tagtatatga tgatttaaat
     4561 ccaagtccca taacatttag catactaagc atcttatcat caattttatc taccatttgt
     4621 tccaacatat aaagtttaaa aggagtttct tctcctgtta tatagctgat ttcacttttg
     4681 tatgcatata ctttgatatt attcttagat ttttctctta gataatttat gtttcctata
     4741 tggtctatat catgatgagt gattattata ttttttaact tatcaaagct cgtgttactt
     4801 ttattaagag catcaattat taaatcacct tgacccggaa gacctgtgtc aataagtgtt
     4861 gcatcatctt ctgtgtagat tacaggaata tacataactt tatcttcacc gaatacattt
     4921 gatgaaattt ttaaaacatc taatcccttt gctaaattca taatttttct ccttataatt
     4981 acttaattag aggtcaattt aattaaagaa attgagaaaa tgtagatttt cctctagtta
     5041 tattttatta attaaaaatt attaatacct agtatatcat ttaagttgaa ggattactcg
     5101 acttgatttt tttgttattt tatggtatag taattaatat agaagtaagt aattgcaagc
     5161 tttgcaatta cttttatttt tttctaataa ctattttatt tttgataatt cgtataaaat
     5221 taaaagtaaa gtaatataga aaatatgaat atagaaaaac tttaataaga aaataaatta
     5281 tgaataaata aaagaaacgc aatactgtat atagatgatt atttagaaaa ataaaatctc
     5341 ttttaataaa aataagcttc aaaataaact tttagttcat aaagcttagg agtaactaaa
     5401 ttgagtgcaa gtgtatctac tgttcaaaat aaatagttca taaagcactc ttttttatat
     5461 taaatcaatt atattttcgt catttcagca atgaaaaaga agcttatctc tattttgaga
     5521 cagcttcttt ttattaacgt cctacttttt attagttttc taaaattaaa aagctttatt
     5581 tataggattc cttagattta tattttgacg atataatttt ttaaaaacac cttaaaagat
     5641 ggtatacaat acacacaatc atactcataa ttgaaaaata atcaatggaa aacaaaatta
     5701 ctggatattc cctattaaaa aatacaaatt gattcacaag aaacatataa tctataatat
     5761 tatgatgtta ctctcccaca ccaagtaact ttattttcaa gtaacctttt cataccatct
     5821 aacttcactc aataaaaatg gcaatataaa tatatactct attttttact tttaaatatc
     5881 tgacaagctt tatatactat tggaagtaag atacaaagta aaacagccca atctggtaaa
     5941 tgtggcatat aaaagtcccc cttaccttat acaagctcct tattactaaa aattttaata
     6001 gaaataaaca ttgaagctaa cagtataatt aaacttaaaa ggaacaatac aatattcact
     6061 atcatggatg gatactgata tataaatgga atttcaaaat tgctgtgagc tatagttaat
     6121 ggtaatacaa atgatgaagc catgattatc atcacgaaaa agaattttgt tgtttcatat
     6181 cctaatttgt attgaatagg catataaact ccataaataa tagaacttat taataaaaca
     6241 atcaaaatat atgtcaagtc aaaagttcct atttgtggaa taagtaaatt ttcaatccag
     6301 taaactaatg tacaatagat aaataccatt gcaaataaaa catacttaga ttgaactaag
     6361 ccacgtctag gataaggagt tgaacaaagt aatacagatg cttttgaata ttgactctcc
     6421 tttaataata gatactgaca cagcataaat tctgaaaata taattgatag tacaaatccc
     6481 aatatttgtg caaatggagg taaacgccat aatataaata atgggattcc tattgcaata
     6541 aataatatca acaatacata tttttttaca atcagaatat cttttttaac taaatgaatc
     6601 aacataatta ctctctcctt tcaatatatg caagcataat atcttcaatt gtaggacgct
     6661 ctattaaaat atctggcata tttttttgca cttcattaat ttttgaggta atccctataa
     6721 aaccataacc tgtaatttct aaatttaaaa ataatttttt ggtttcatca tttagaaatt
     6781 gaatatcccc ttttactttt ctatgttcgt ccaatagagt atctttttca cgctctaata
     6841 taatacgtcc attgtcaatc ataacaatca tatctgctat tttgtctaaa tcagatgtta
     6901 tatgagtgga aaagaaaaca ccacgaccac atttcttcat atatcctgtt agtatgtcaa
     6961 gtatctgact acggattagt gggtctaaac cacttgtagg ctcatccata attaaaaact
     7021 cagctttatg cgataatgct aatgctaaag caaatttcat tttcattcct tttgaaagtg
     7081 tatcaatctt ttgttttggg ttaagattaa aacgcttcat attttgttga taatcttctt
     7141 cacaccaatt atcatatgaa ggtgcaataa tacttttcat ttctgccatt gacaactcct
     7201 catagaaata tgaatcatca aagacaactc caattcgatt ttttaattcc ttctcatttc
     7261 catcgaaatc tttaccaaag atttttattt ttccactatc acgctttacg acatccaata
     7321 tcgaacggat tgttgttgtt tttcctgctc cattaacacc tataaatccg gttatacaat
     7381 cttctggtaa tgcaaagctt atattagata atgaaaaatc ggtataagtc ttatttaagt
     7441 tataaacttc taaaatattt tccatattaa tcctcctcat atagaatatc catcatttct
     7501 tgtaactcta tctgtgtaat tcctagtgct tttgcatctt taatcatatc tgccattttt
     7561 tgttcaacta tacgtctctt tgagtctctt agtatttcta aatttccagt tgaaataaat
     7621 gttcctattc caacttggcg tgtaagaaag ccttcatttt caagttcttc atacactcgt
     7681 ctaatagtca aaatactaac ttttaaatca ttagcaaaat ttcttatgga tggcattgca
     7741 tccccttctt tcagttcttc agtaaatatt gcttctttaa tttgctcttt aatttgttgg
     7801 tataatggct tatctgatgt gttagaaatg agcactttca ttttttatca cccccttttt
     7861 atcactttca gtgtgatgtt atcatataca cactatacac ttagagcact tttttgtcaa
     7921 tataaaagat gtaaaatatt actatgacaa aataaatatg aatgaaatat tagagattgt
     7981 taatagccat aaacactttt taaaactaca taagatagga tgtattaaat atttattaaa
     8041 agtaagaatt gaatatataa aagaaaaagt aatcctgtat gaatgatttg tttaatgata
     8101 aattaagtta taaactattt ataaaaaaca taaaggaata aatccatttc taattacaaa
     8161 catactaaaa aatttagata ataataaata aatagtaata aatgggatga atttataaga
     8221 atttggatag aggaaagagt tattcaagag tgtagactag aggtaaactc tatattaaaa
     8281 aaatttaaat tgggatatta ttatgtatgg aatatttgca gaagtaacct tgctataagt
     8341 atagaagatt tttttgatta caaaagataa tactctaaaa tgtgaggatt tcaacattca
     8401 atactgtgct ttaaataata tcactccaaa ataccatcca ccttttacta taattgaata
     8461 ccctaattat tttaaaaaag aaaacattag aaacggaaaa ccttgtatat ataaaataaa
     8521 aaatactaac ttctaaaaca cgaatactct ttgataaata aaacaaaaaa taattttaat
     8581 aattaaaatt ggctatctca aactagagat aagtctcttt ctcactttta aaacgttgaa
     8641 aatatattcg atttcgtaca aaaaagagtg ccttagaact aaaaagttca ctttgtggca
     8701 ctcccttttt tctcctcttt ttaatttttt ataaaaattc ttcaaaaata ttattaaata
     8761 ccctatatta tacataaatc aaattaaagt tgcattttag caaataaaaa caaattataa
     8821 ctattagcat agcaaataaa aaatctgcta tcttataaaa tcaaaattat aattataaaa
     8881 agaaaatatt cttataacaa attaactaat ataaaattat tttataaatt aatactactt
     8941 tttagcttct cctataaatt aataccactt ttttaactat gaaacctatc tacaacattg
     9001 gtaccataag accagctacc acaatagaaa tcatacaagc cataccacca actaccagct
     9061 taggcataat cttagacatc aaatatgctc tttcttcttc cgtttctcca acagcattac
     9121 acacttcatt tgaaattaaa tatgtagttg ggaatcccaa catctgacaa aaccctactc
     9181 caaaagcaag aggtttagaa ccgataattt tccaacctgg taacaccttc atcataagga
     9241 atataccaat gatagaagct gcaaacatac ccacaattgg tacaaaaaga ctaattaaat
     9301 ctgtcaaaga aacttttgct aaagaaggaa taacagctgc aaacacaacc atgttgataa
     9361 atcccttgat ttttcctttt tccaaaatgt cttttggcac aataccaata cgtgttacaa
     9421 taacaccaac aacaagacat acaatagaat aatttacatg aataatctct gaaagttcat
     9481 accctagata agagaataat gctataaaaa atatacaaac atttgtagaa taatatttat
     9541 cgtatttttc acagaaagct tgttttactt ttgtgcctgt attctctgct tctttcttat
     9601 cagtatcaac atttgctaaa tcaatgcctt ttgattttgc ttcatgatat tctactaaaa
     9661 gacggtttgc ctcttgtaac gctgctcttg aagctattgg tgtaccaata aacttctgaa
     9721 ttgcaaatac aactgttgct gtagctgctg caagtgtcag tcctttttct agtgctgctt
     9781 gtgtcataat agtagtagca ggtaaagctc catttataac tggtatgctt gtcaatactg
     9841 ttgattttcc aaacaaagga atacataatg agacacagac tataactgct acaattccaa
     9901 gccatgctgt caatactgtt ctccattcgt ctataaattg tttaacattc aacattgttc
     9961 ccatactaaa cataatcatt ggaacactcc aactagctgc tgcggtcata cctgcttttt
    10021 caataatatc agctggtatt gcttttgtga caaatagaat caaaaataaa agtagtgtaa
    10081 caaatacagc tgatactttt gcttttgttt tgcttgcaat taaatcccca atagcaaata
    10141 aaactaatac gacactaaac cataataaca tatcactcat agaataaccc ccttattata
    10201 aatatctttc aaaccaatct acaatagcat ttgctcttgc aattctatta gatggtcttc
    10261 catttctaga caatccatgt gtatctccat gaaacaaata catttctgta tctacaccaa
    10321 gctgttttaa tgctgtaaac atttggaaag tatcccccat aaaacatcta taatccctat
    10381 cactatgtaa gaacaatgtt ggtgtcttaa catttttcac atatttaata ggtgaatgat
    10441 tccaaagaac ctcctcatga ttccaaggcg tcttatctcc acaagtctgc ttcataattc
    10501 tatccccaaa gtcaataatt aaagaagctg taatcaagtt actaatacct ctttgagaaa
    10561 ctgctgcttt gaaacggtct gtatgaccaa ttatccagtt tgtcatataa ccaccgtaac
    10621 ttccccctgc aacccctaag cggtctgcat caatcccagg atatttttca atacaagtat
    10681 ctacaaattc cataagatgc tcatagtcaa cataccccca tctttctacc atttctaaga
    10741 atttttcacc ataaccgtca ccaccatgag ggttacaata aatcacatac attccctttg
    10801 atgttacaca ctgcttcaag tgtgtaaaca tatagccata tgcccattta ggcccaccat
    10861 gaatgaacaa tacagcagga tatttttcgc cttctttagc atctataggt ggtataacaa
    10921 aaccatcaac ttcttcttta ttttttgcta caaacgtcaa tttttcaggt aatgaaacct
    10981 tatgagtatc taaatatggt ttagaaaaag cagtcatttt tttcattgta cctgtagtca
    11041 tatcaatgct atatatttct gctaactcat aatctttcaa cattactgtg tacatggtgt
    11101 tgtcgtaaat atcaaaagat gtaaaagcat ctacttttgt gatgatacgt atattacctg
    11161 tctttgtatc aaactcatta aattctgtca tagttctgca aattcttgca ccaataaatt
    11221 tgtctcctat aactttatta ctacgtccac caccatatac tgcatctaca tccagcaatg
    11281 tagcatacat accatctgga ctagcaatca tatttatttc attagtactc aaatcaagta
    11341 taaaaatatc atgattctgt gtgatagaac ggtctaatgt tgaagcttgc aacattactt
    11401 tatctttgcc aatatatttt gccaaactta tttggtactt tccttgtggt acaagttctt
    11461 tggtttcacc actgtctata tgatactccc aaagtccaga aaaaggagtt gcacaatctt
    11521 cataaatctg accagtatat aaaattctgt ttttatcaga agaaacgtct acacctgcta
    11581 cttcacaaaa ttttggtgta atggcttttg ttatattttc accttcttga tataattcta
    11641 atgttacacg tcttctttga gaaaaatttt ctccatctct tataaaaggt ttatctgtaa
    11701 atgtccaata atctacaccc tctactgccc tatctggttc tgatttttta gaatccgttg
    11761 gattttttgt tgtcagtaac cacaatttat ttccaagtga tacaggtacg ctacaagctt
    11821 ttggaataga aaatgctttt tttgcttctc ctccttctat agaaatagtg taaaaatctg
    11881 ttgtacctga ttttggctta tttcttttag atgtaaaaag gagttctgta ttagaaatcc
    11941 aactaaatga tgttacatct tttgtttgag tcatatgtat ttgtttttct gttttgatgt
    12001 ccatcacata taagtcatgt tcatagcagt ctttttcctc gttgatattt gatataatat
    12061 aagcaatatg ctttccatca ggtgaacaag aaatatcatg agggaatata tattcaaaaa
    12121 tatctgaatt ttcaatcttt attttttcca tttttatatt ctcctttcta ctgtcctatg
    12181 ttatcttttt ttatatatac tgaaaaccaa tctagcattt caactaatct ttgtagcttt
    12241 tgttttggtc taccagaacg agacagttca tggttttctc cttcaaatag acaaagtttt
    12301 gtaggacacc catgaatttt caatgctgaa aacatctgga atgcttcttg catatagcat
    12361 ctatagtctt tttcaccatg taaaaataaa gtcggtgtaa cacatttatc agcataagca
    12421 agaggtgact gtttccattg aagctcgtgg ttttccatat gagaagcacc tgtttgtcct
    12481 ttgcagaaat aataaccaat gtctgttgta ccctccatgc cactccagtt tgcaatagaa
    12541 cgctgagcac aagcaacagc aaaacggttt gtatgaccaa ttatccaatt cgtcataaat
    12601 ccaccataac ttccaccttc aacagccaat tttgttttat caatgtctgt atatttttca
    12661 agtacagtat ctgtaaattc cataaaatct atataatcaa tatctccaaa ctgtttccta
    12721 atatctgcaa aagcattgcc acgaccttca gacccccttg ggttacagaa gaatacaaag
    12781 taacctgcac ttgtaaatac ctgtatctca tgcataaaat atggtccata tgtcaatctt
    12841 ggtcctccat gaatcgccaa tacagctgga tattttttcc ccacctcata atctactggt
    12901 ttatatacgt atccttgtat ttcccattta gaacttcctt ttgactctat gtattctggc
    12961 acagaaattt tatattcctc taaaatatgg tcatttaaat gtgttttctt acacaatgtt
    13021 ccattctcta ctgtataaac ttctggtaat ccatttccta aacaacccac acatacaata
    13081 ttgccatctt ttacatctat aaaatcaact gaacctgtct gtgttacttt ttcctgtttt
    13141 cctgttggaa tatgtattct ttcaataatg cagtccatat ctactgtaga agtgtaataa
    13201 atatattctc catctacctt tgttgtctga ccagcaccca ttttaacatc agatgttact
    13261 gtatttccaa tacaatgatg ttgatgccct gaaagaagtt tcatttcttt cgtatcaata
    13321 tcaatagtat aaaaatctcc attttctcca tttccataag ataaagcatc agttaggttt
    13381 agtatcactt gattttgata taattcaaaa ccttttataa tatacttatc tttttctaat
    13441 atacagacat ttgtgtttgt gtttgtatca aatacataga ccccattttt caaacctttt
    13501 acatctttaa actcttgccc tatatataag atttttccat cacttatttt catacctaca
    13561 acattaaaca taggtgctgt aattgccttc aactcattta tattactgtc gtatacatat
    13621 aggcgttttc tttttctgct aatatatccc tccccattga cagcataagg aatttctttg
    13681 aaatgttcat aatgtctttt gttataagca tttatttttt tctgttgttc ttcttctggc
    13741 aatccctcta caataggtcg gtcattgtca taagaatcaa taactgcata caaacctttt
    13801 cctataggat tcaatttacc acctttgata gggagtctaa aaagttcttc tgcttctcca
    13861 ccatttaaag ataaagcata gtaactcatg cattgcttac cgtttttgac agcttctttt
    13921 actttttcat ttcgcaaagc agggaacaag atagtatttt catcttccca ggcatatgct
    13981 ccaacagagt ttatagacgt tatttgtttt aattcgccag ttttattgtt taatatataa
    14041 acttggcttg tgtaaccatt ctctttgata tcagcttttt ttacaataaa tgctgtatat
    14101 cctccatctg gtgatatttg gcaatcactt ataaattgat attccaaaaa tgtttcactc
    14161 gtaaatagct ttttcatagt attttctatc ctttctttag taattttttt caaactctct
    14221 accacctctt tcatttttta ttttaaattt aaaataaaaa attttaaatt taaaataaaa
    14281 aattttataa aggttatttt tttaggaagc cttctggctt ccttgtaata tttgtaattt
    14341 aaagtatatt taatccatgc ttaattcatg cttaattcat acttaatcta tacttaatct
    14401 atacttaatc tatatttaat tcatacttag acttatttac actatattta gattatattt
    14461 attagattat atttagatta tgtttaaact ataattagat tatacttaga ctacatttag
    14521 caacttaata gataagtata tatagtaact tcaaaactta ttattcatct tcacagaatc
    14581 ttttaatagt tccttgaata tgatttctta gtttatctac tgcttttttt gtatctctgt
    14641 cttcaatgaa ttttaatatt tcaaaatggt cttgtactgt tccttcataa ttacgatttt
    14701 ttaatggtcg aattaaatag ttcactacta taaatcttcc ttgtatacca acatatacat
    14761 catttaaaat ctcattattt gccccttcta caatggcttt atgtaattcc aaatctgcta
    14821 gtgcaagttc tacagatttt tcttgacgat agtactcctc gcatttatca gagtatcttt
    14881 ttattacatc tagcttttgt tgaaaaacct cttcctcttc ttgcatcatt ttttctaaag
    14941 catatgtttc aatcagtgtt ctcgtttcac aaacttgttt taccatatca tattcatact
    15001 ctggtacgta cactttacca tttgtcataa tagtaagcac tccatcttta tttagcattt
    15061 ttactgcttg tacaactggt gttctgctta cttcaaattt ttcacaaagg tcatttagta
    15121 atattttttg acctacagag tattcaccac gaataagact ttcaataatc ttatgatata
    15181 aaatttcatc taaatttgac tttactttca ctactctcac cttatttcta ttcttttgcc
    15241 atattatatt gaattactgg actttaatta cttttagtaa tatttttaaa gtagaaattc
    15301 ttatttgata gtacttttgt actacaattt aaattattgt actgtaaatc atgctcttat
    15361 actatagatt aattcattgt attgcaaatc aagttattgt actatagatt aaatcgttgt
    15421 acttcaaatt aaactattat actatagatt aaaccattgt acttcaaatt aaactattat
    15481 actatagatt aaatcgttgt acttcaaatt aaactattat actatagatt aattcattgt
    15541 acttcaaatt aaactattat accatagatt aattcattgt attgcaaatc aagttattgt
    15601 actatagatt aaatcgttat acttcaaatc aagttattgt actatagatt aaatcgttgt
    15661 acttcaaatt aaactattat actatagatt aaatcgttgt acttcaaatc atgctagtgt
    15721 actatagatt aaatcgttgt acttcaaatc atgcta
//
LOCUS       DAEPID010000086        15403 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.086, whole genome shotgun sequence.
ACCESSION   DAEPID010000086 DAEPID010000000
VERSION     DAEPID010000086.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 15403)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 15403)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..15403
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.086"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            <1..413
                     /locus_tag="KR257_003131"
     CDS             <1..413
                     /locus_tag="KR257_003131"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888399.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=3
                     /transl_table=11
                     /product="transposase"
                     /protein_id="HBH0031802.1"
                     /translation="VARFQEHIANQRKDFLQKLSTKLIKENDIICIEDLQVKNMIRNR
                     KLSRLISDVSWSEFIRQLEYKANWHGRQIVKVGKFFASSQICNKCGYKNEEVKDLNIR
                     EWICPSCNETHDRDINASINILKEGLRLITIQNK"
     gene            546..2051
                     /gene="ade"
                     /locus_tag="KR257_003132"
     CDS             546..2051
                     /gene="ade"
                     /locus_tag="KR257_003132"
                     /EC_number="3.5.4.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428612.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="adenine deaminase"
                     /protein_id="HBH0031803.1"
                     /translation="MSPGFIDAHMHIESTMVMPIELSKKLLKSGTTTIIADPHELVNV
                     KGVSAIDFLLESTKDIPLNVYIMVPSSVPATSFETNGVGKFSAKDMESYVNNPRILGL
                     GEVMCFNDVINSENEILDKLELFKNKVVDGHAPNINGKSLQTYVCAGIENDHECITFD
                     EVYEKLRAGLKILIREGSAAKNLKSIVSGMLKHNLPIEEFMFCTDDKHLDDIEKQGHI
                     RWNIKCAIDLGMEPVRAIKVATYNSAKAYGLRKIGAIGAGYKADIVVLNDLDKMEVDS
                     VYKDGNLVNEEMFSNYNYEIKDKELLNTVKFKYINKEKIQLKVSEKNYVMEIVPYQIL
                     TNKVYESLPCADGYFVPNKEYSKLCVVERHRMTGNVAVAPLKGFGIKNGAIATTVAHD
                     SHNIIVAGDNDDDILVAINYLKEIQGGYVIVSNGKVLAHLSLQVAGLISTFTAEEVQE
                     ITDNMLEIARKMGVPEYVDPFITLSFMALPVVPQIRLTDLGLFDVEEFKFI"
     gene            2403..2867
                     /gene="bcp"
                     /locus_tag="KR257_003133"
     CDS             2403..2867
                     /gene="bcp"
                     /locus_tag="KR257_003133"
                     /EC_number="1.11.1.24"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002586316.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="thioredoxin-dependent thiol peroxidase"
                     /protein_id="HBH0031804.1"
                     /translation="MLSIGTKAPEFTLEDKDGNKVSMSDFKGKKVVVYFYPKDNTPGC
                     TRQACAFRNAYDGFKKEDIQVIGISKDSIKSHQKFAEKHELPFILLSDPDLVAIKAFD
                     VWKEKKMYGKTALGVVRATYIIDENGIIEKVFEKAKPDTNAQEILEYLEKQE"
     gene            2877..3620
                     /gene="yaaA"
                     /locus_tag="KR257_003134"
     CDS             2877..3620
                     /gene="yaaA"
                     /locus_tag="KR257_003134"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428614.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peroxide stress protein YaaA"
                     /protein_id="HBH0031805.1"
                     /translation="MIIMLSPAKNMKNIEVFDRDLSLPCFIDNTKEIVENIKTFGIED
                     FKNKMKINEKLAVLNKNRFESIKFDRLGNPAILTYDGIQYKNIEAENFTRKDEEFANS
                     CIRIISGLYGVVKPYDSIYEYRLEMQTKLRVGEFKNLYEYWGNRIYKELIKEKTAIVN
                     LSSNEYSKSIEKFIKDSDTYITCTFKVNKNGILKVESTQAKKARGMMTKYIVKNRIRD
                     IEELKKFNLEGYKYKENLSNNSEYIFVKE"
     gene            3748..6405
                     /locus_tag="KR257_003135"
     CDS             3748..6405
                     /locus_tag="KR257_003135"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728628.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cation-translocating P-type ATPase"
                     /protein_id="HBH0031806.1"
                     /translation="MENHKQMPWHSRATHEILESLDSSEEGLTDTEAEKRLKENGLNE
                     LRKKPPRTTLQMLWSQITDAMVMILIGAAILSLIFGEFTEAFVILIIVTVNAVIGIVQ
                     EKKAESSLEALKNMNSPTARVMRDGEENVIPASNLVVGDIVFLEDGAMVPADLRLIET
                     SSLKIQEASLTGESVPSEKDADTILPKECVLGDRSNMAYTSSIVTYGRGVGVVVATGM
                     DTEVGNIAHLLDSQDDFDTPIKRKLNTVGKTLSVIGIIVCVVIFAIGAFYQRPLLPMF
                     MIAISLAISIIPEGLPATATIVMALGVQRMAKRNALIRKLPAVETLGGATVICCDKTG
                     TLTLNKMTVTHIAVNGDFESGKVTSIDTASEKHPLVYKEIVYAGALCNDACINPDKTD
                     EILGDPTEGALIFMAKKFGIDQEALEEEYPRVFEQPFDSDRKCMTTVHNIDEKIIAYT
                     KGAVDEILDLCTKILTSKGERNITEVDKKNIHELCLNMSKDALRVLGFAKREISSIPK
                     EDSENIEYDLTFIGMVGMIDPPRTEVIDAVSTCKEAGIRTIMITGDHKVTATTIAHEL
                     GIWSEENTVISGDELDNLSDDELDEAVKNTTVFARVSPFDKLRIIQSLKRIGEVPAMT
                     GDGVNDSPALKSADIGIAMGISGTDVAKDSSDMILMDDSFTTIAYAIKEGRRVYRNIQ
                     KVIQFLLVGNIAEILTLFVAILLNWDTPLLAVHILWVNLATATLPALALGVDPPSRNI
                     MKHQPVKSTTLFEKNLIQRVVTQGIFVAIMTILAYKIGLNIENHSVGQTMAFCVLAFS
                     QMLRAFSQRSNTDSMFNRNNGKNPFLLISFLTSAFLIAVILFAPVFRNAFNLTVLNNL
                     EWLITIVLAIMSVIQVEVGKIIKRKKLKK"
     regulatory      6459..6561
                     /regulatory_class="riboswitch"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00162"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="SAM riboswitch class I; Derived by automated
                     computational analysis using gene prediction method:
                     cmsearch."
                     /bound_moiety="S-adenosylmethionine"
                     /db_xref="RFAM:RF00162"
     gene            6671..7936
                     /locus_tag="KR257_003136"
     CDS             6671..7936
                     /locus_tag="KR257_003136"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728629.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="O-acetylhomoserine
                     aminocarboxypropyltransferase/cysteine synthase"
                     /protein_id="HBH0031807.1"
                     /translation="MYNKETICVQGNYKPGNGEPRVLPLYQSTTFKYSSIDQLAELFD
                     LKVDGHIYSRISNPTIQAFEEKISLLEGGVSSVAVSSGQSANMLAVLNICKSGDSILC
                     SSKVYGGTFNLLGPSLKKFGIDLISFDLDSSEDEIVELAKENTKVVFAETLANPTLEV
                     IDFEKIANVAKRINVPFIVDNSLASPVLCNPLKYGANIVTHSTTKYLDGHASSVGGII
                     VDGGNFNWDNGKFPELVEPDPTYHGISYTQKFGNAAYATKARVQLLRDYGNCLSPFNA
                     YLTNLNVETLHLRMERHSENALKIARFLEKHENVDWINYPGLEDNKYYENAKKYLSRG
                     CSGVLSFGVRGGLENAKKFVEKLQIASLVTHVSDVRTCVIHPASTTHRQLTEEQLIAS
                     GVLPSLIRLSVGIENVEDLIADLNQALNF"
     gene            7966..8856
                     /gene="metA"
                     /locus_tag="KR257_003137"
     CDS             7966..8856
                     /gene="metA"
                     /locus_tag="KR257_003137"
                     /EC_number="2.3.1.46"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423895.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="homoserine O-succinyltransferase"
                     /protein_id="HBH0031808.1"
                     /translation="MALILPKGLPVINKLLDEGIDVIYKEDFKKELKYEENIDTKIAI
                     LNLMPIKIDTELDLLRRIDKTGFNVSVEFIKISTRESKRSCNEYVKEFYKTFDEAKGE
                     YFDGFIITGAPVEQMEFEEVDYWNELEEIMDYSKRKTKSTLYICWAAQASLYKYYNVK
                     KLPLSQKCFGVFKHKVDKDSKIVDGFENEFFAPHSRHTTVNIEALKENKELSIVSHSK
                     EAGPYIITNSRDVFVMGHSEYDKYTLDKEYKRDINKGDKISIPQNYYINDDPSEEPTV
                     KWKKHSELLFRNWIKNYLIQ"
     gene            9344..9787
                     /locus_tag="KR257_003138"
     CDS             9344..9787
                     /locus_tag="KR257_003138"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423898.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MarR family transcriptional regulator"
                     /protein_id="HBH0031809.1"
                     /translation="MDEMSFKKELLELTRDINMKFTTLLSDFYQPLGITAVQALILSE
                     LCEHGEKKISDLGKNLNMTNSNVSVICQRLEKNGFLNRIRDIEDQRIVKVKVTNKSLD
                     IQEHISSSIFDSYFENMTSEKLQDMEDIIEGLEKLNKLLTYIDCK"
     gene            9818..11635
                     /gene="ftsH"
                     /locus_tag="KR257_003139"
     CDS             9818..11635
                     /gene="ftsH"
                     /locus_tag="KR257_003139"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423899.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-dependent zinc metalloprotease FtsH"
                     /protein_id="HBH0031810.1"
                     /translation="MDEHKPQKRSALYYYTVIIIVVMFLNALIFPSLMDKKMVEIDYG
                     KFLTMLDTGKVKSVEIENNRIAINPSSSKDKNIYITGRMDDPELVDRLKNAKVEFTKV
                     IPKENSPLLSILLTWIIPIGILMLFGNLMMKSMQKRMGGNAMQFGKSNAKMYVSAQSG
                     KRFNDVAGQDEAKEALTEIVDFLHNPEKYKKIGAQMPKGALLVGPPGTGKTLLAKAVA
                     GEANVPFFSISGSEFVEMFVGMGASRIRDLFKQAKEKAPCIVFIDEIDTIGKKRDNGS
                     GLGGNDEREQTLNQLLSEMDGFDGGIGVVILAATNRPDSLDKALLRPGRFDRRIPVEL
                     PDLGGREAILKVHAQNVNVSSDIDYNAIARSTSGASGAELANIVNEAALLAVKSGRDI
                     VEQQDFDESVETVIAGYQRKGAVISDKEKKIIAYHEIGHALVAAMQKHSAPVHKITII
                     PRTSGALGYTMQVAEDESVLMSKEEAIDKITTFTGGRAAEEVIFNTCTSGASNDIEQA
                     TKIARAMVTRLGMSEEFDMVALETVSNQYLGGDTSLACSSDTAAKIDEEVFKIVKACH
                     KNAIEILENNIDKLHELANYLLEKETITGDEFMEILNLN"
     gene            11813..14515
                     /locus_tag="KR257_003140"
     CDS             11813..14515
                     /locus_tag="KR257_003140"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897026.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sensor histidine kinase KdpD"
                     /protein_id="HBH0031811.1"
                     /translation="MDRPNPDILLEKIKNEEEKLSRGQLKIFFGYAAGVGKTYSMLES
                     AQNLKKVGVDVVVGYIEPHTRPETLALLDGLEILPVKEIEYKSIKLKEFDLDAALARK
                     PEVILVDEFAHSNVAGLRHTKRWQDIEELLLAGINVYTTVNVQHLESLNDIVEIITNV
                     SVKETIPDKFLDTNTQLELIDVEPDVLLERFNEGKIYKKEQATRAKNNFFIKDNLVAL
                     REIALRKTAERVNKEVQMTRLSKGDVTVIPTSDTLLACISPSPSSAKVIRTASRISDS
                     TFAKWIALYVETPNTARLPFDEQKQLQNNLKLAKKLGGEIIVLHGENIIEQILRIAKL
                     RNVTKIVIGRNHSSNKRFSKRFKKDIVDKLIDEVDYIDIHIIPYKFASDVKYKPKKDK
                     SSIKSKFKISKVDFIKLIFITLMISILAYAVQSMGFIRENILLIYMLGVVLVSMWTKG
                     YSTGIISSVFNIVLLNYFFTAPLYTLSIADSNYIVTLVVFSIVGIITSTLTSKIQHEA
                     ETAAKREENTKMIYQIIKGFLRLSNKDDIVNKGIELLSLSLSRDVICYLNVDKHNKSK
                     LYKKNTNNKDKNDLDSEDEKAVASWVLSNSTVAGNDTDTLPGSKGYYIPIVGMNLTLG
                     VVGISCIDSKLDTEDISLIETIIAQMAIALDREILSEAKENTNLEIERERLRSNLLRA
                     VSHDLRTPLAGISGAVSTIIKNKGTIGQDIIDELLSGVYEDTQWLIRLVENLLSMTKI
                     DEGKLEVKKHSELVEEIISEALQKIKKRIENALIDINIPEQILFVPMDAKLIEQVLIN
                     LIDNSLKYSKEDCKIEINVYEKDDYVWFEVSDNGPGISKELKKHIFDRFFTGEEGAKD
                     SRKGVGLGLSICKSIIQAHKGEIMVENNKDKGSTFKFSLPKENE"
     gene            14549..15247
                     /locus_tag="KR257_003141"
     CDS             14549..15247
                     /locus_tag="KR257_003141"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003439430.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HBH0031812.1"
                     /translation="MSKKLILLVEDDKTIRKFISTALLTQDYDVKEAITGKEGISIAV
                     SYSPDVVLLDLGLEDMDGIEVIKAIRQFSNIPIIVVSAREQDRDKVEVFDAGADDYLT
                     KPFSIVELLARVRVAFRHSQVEAQQKDDVKSTFEVDKLLIDFDKRKVIVDDVEVHLTP
                     IEYNILSLLAKYHGKVLTHNFIIKEIWGSVIGNETKSLRVFMATLRRKIEKQPANPRY
                     IITEVGVGYRLNDE"
BASE COUNT         6039 a         1759 c         2823 g         4782 t
ORIGIN      
        1 aagttgcaag atttcaagaa catatagcta atcaaagaaa ggattttcta caaaaattat
       61 ctactaaatt aataaaagag aatgatatta tttgcataga agatttacaa gtaaagaata
      121 tgattagaaa tcgtaaacta tctcgcttaa tttctgatgt gtcatggtca gagtttattc
      181 gtcaattaga atacaaggct aattggcatg gtagacaaat tgtaaaggta ggtaaattct
      241 ttgcaagttc acaaatatgc aataaatgtg ggtataaaaa cgaggaagtg aaggacttaa
      301 atataagaga atggatttgt cctagttgta atgaaactca cgatagagat ataaatgcaa
      361 gtataaatat attaaaagaa ggattaagac taataacaat tcaaaataaa taacgtatgt
      421 aagaaccgta ggaactacgg ggatagcctg tggagaatta gtaagacata ttttagtatg
      481 caaaattctg tgaagcagga accctgtgac tttagtcatg ggaggttcag tgtagcaata
      541 aatatatatc acctggcttt attgatgcac atatgcatat tgaatctaca atggtaatgc
      601 caattgaatt atcgaaaaaa ttattaaaat caggtacgac aactatcata gccgacccac
      661 atgagttggt caatgtaaaa ggagttagtg caatagattt tttattagaa tcgacaaaag
      721 atataccact taatgtatat attatggtgc cttcatccgt acctgcaaca agttttgaaa
      781 ctaatggagt tggtaaattt agtgcaaaag acatggagag ttatgtaaat aatcctagaa
      841 ttttaggttt aggagaggta atgtgtttta atgatgttat aaattctgaa aatgaaatct
      901 tggataaact agagcttttt aaaaataaag ttgtagatgg acatgcacct aatataaatg
      961 gtaaatcact tcagacatat gtatgtgcag gaatagaaaa tgaccatgaa tgtataactt
     1021 ttgatgaagt atatgaaaaa ttgagagcag gattaaaaat tttaataaga gaaggaagcg
     1081 cagcaaaaaa tttaaagtct atagtaagtg gtatgctaaa gcataacttg ccaattgaag
     1141 aatttatgtt ttgcacagat gataagcact tagatgatat agaaaaacaa ggtcacataa
     1201 gatggaatat aaaatgtgcg attgatttag gtatggaacc tgttagggct ataaaagttg
     1261 caacttataa ttctgcaaaa gcatatgggt taaggaaaat tggagcaata ggtgcgggtt
     1321 ataaggcaga tattgttgta ttgaatgatt tagacaaaat ggaagtggat agtgtatata
     1381 aagatggtaa tttggtaaac gaagagatgt tttctaatta caattatgag attaaagata
     1441 aagaattgct taatacagtc aagtttaaat atattaataa agaaaaaata cagttaaaag
     1501 taagtgaaaa aaattatgta atggagattg taccttatca aattttgaca aataaggtat
     1561 atgaatcttt accatgtgca gatggatatt ttgttccaaa taaagagtat tcaaaacttt
     1621 gtgttgttga gagacataga atgactggaa atgtagcagt tgctccacta aaaggatttg
     1681 gcataaaaaa tggagcaatt gctactactg tggcccatga ttctcataat attatagttg
     1741 caggggataa tgatgatgat attctagtag ctataaatta cttaaaggaa atacaaggtg
     1801 gttatgtaat tgtatcaaat ggaaaagttc ttgcacacct aagtcttcaa gtagctggat
     1861 taattagtac ttttacagct gaagaagtac aagaaattac tgataatatg ttggagatag
     1921 caagaaaaat gggagttcca gagtatgtag acccttttat tacactttct tttatggcac
     1981 ttccagttgt tccacaaata agacttacag atttaggtct atttgatgtt gaggaattta
     2041 aatttatata gataatataa aagtaataat aaatgaggct ttctcaaaat agggataagt
     2101 ctctttttat tgttgaaatg ataaaaatat atttgatttc atacaaaaaa gagcatctca
     2161 tgaactaaaa attttatttt tagatatcct tattttaatt aatctatcat ttaaccttgt
     2221 tttaagcata gatatcttaa taaaactatt ttcagtctat tttaacatat aaatacatga
     2281 aaattatata tttatgaaac tttatacata aaaaataaaa tattttattt atatatagat
     2341 ttatagggta ataatataag catagtataa aattattaat aaaaacaaaa ggagagatat
     2401 ttatgttgag tataggaaca aaagcaccag aatttacact agaagataaa gatggaaata
     2461 aggtaagtat gtcagatttt aaaggcaaaa aagtagtagt atatttttat cctaaagata
     2521 atacaccagg atgtacacgt caagcttgtg cttttagaaa tgcatatgat ggatttaaaa
     2581 aggaagatat acaagttatt gggataagta aagatagtat aaaatcacat caaaaatttg
     2641 cagaaaagca tgaacttcct tttattttac tttctgaccc tgacttagtt gctataaaag
     2701 cttttgatgt atggaaagag aaaaaaatgt atggaaaaac tgcattggga gttgtacgtg
     2761 cgacatatat tatagatgaa aatggaatta ttgaaaaagt ctttgaaaaa gcaaaaccag
     2821 acacaaatgc acaagagatt cttgaatatt tggaaaaaca ggagtaataa gaatttatga
     2881 ttataatgtt atcaccagct aaaaatatga agaatataga agtatttgat agagatttga
     2941 gtttgccttg ctttatagat aacacaaaag aaatagtgga aaatataaag acatttggta
     3001 tagaagattt taaaaataaa atgaaaatta atgaaaaatt agctgtatta aataaaaata
     3061 gatttgaaag cattaaattt gatagattag gaaaccctgc aatcttaact tatgatggaa
     3121 tacaatataa aaatatagaa gcagaaaatt ttacaaggaa agatgaagag tttgcaaata
     3181 gctgtattcg aatcataagt ggattgtatg gtgttgtaaa accatatgat agtatatatg
     3241 aatatagatt agaaatgcag acaaaattac gagtaggtga gtttaagaat ttatacgaat
     3301 attggggaaa tcgtatatat aaagaactaa tcaaagaaaa aacagctatc gttaatcttt
     3361 catcaaatga atacagcaaa tccatagaaa aatttattaa agatagtgat acatatatta
     3421 catgtacttt taaagtaaat aaaaatggca tattaaaagt ggaatctaca caagcaaaga
     3481 aagctagagg tatgatgaca aaatacattg taaaaaatag gataagagat attgaagaac
     3541 tgaaaaagtt taatttagaa ggttataagt ataaagaaaa cttatctaac aatagtgaat
     3601 acatatttgt aaaagagtag aagttttgtt aaatattaaa tggcattgtt aaatttaggt
     3661 aaaatatact tagtgtgtat tgaattgaac ttgattttaa aatataatta ttcttaaatt
     3721 aaaaaaagaa aggagtggtc ttccaaaatg gaaaatcaca aacagatgcc ttggcattca
     3781 agagcaacgc atgaaatttt agaaagtcta gattcatcag aggaggggct caccgatacc
     3841 gaggcggaaa aacggcttaa agagaatggc ttaaatgaac ttagaaaaaa accacctaga
     3901 acaactttac aaatgctttg gagtcaaatt acagatgcta tggttatgat actaatagga
     3961 gcagcaatat tatctttgat atttggcgaa tttacagaag cttttgtaat actaataatt
     4021 gtaacagtaa atgcagttat tggaattgtt caagagaaaa aagcagaatc atcattagaa
     4081 gcattaaaaa atatgaactc acctacagct cgtgttatgc gtgatggtga agaaaatgtt
     4141 attccagcaa gtaatcttgt agtaggagat attgtttttt tagaagatgg agctatggtt
     4201 ccagcagacc ttcgtttaat agaaacatca agtttaaaaa ttcaagaggc ttctttaaca
     4261 ggagaatctg ttccatcaga aaaagatgca gatacaatct tacctaaaga atgtgtatta
     4321 ggagaccgta gcaatatggc gtatacatct tcaatagtca catatggtag aggtgtaggt
     4381 gttgtagtag caactggtat ggatacagaa gtgggtaaca tagcacatct tttagattca
     4441 caagatgatt ttgatactcc tataaaacgt aaacttaata ctgttggaaa gacattaagt
     4501 gtcataggta ttattgtatg cgttgttata tttgcaatag gtgcatttta tcagagacct
     4561 ctcttgccaa tgtttatgat tgcaatttcc cttgccatat caattattcc agagggatta
     4621 cctgcaacag ctactattgt aatggcttta ggcgtacagc gtatggctaa aagaaatgct
     4681 ttaattagaa aattacctgc tgttgaaaca ttaggaggag ctacagtaat atgttgtgat
     4741 aaaactggta cgttaacctt aaataaaatg actgttacac atattgctgt caatggagat
     4801 tttgaatctg gaaaagtgac atcaatagat actgcatctg aaaaacatcc attagtgtat
     4861 aaagagattg tttatgctgg tgcactttgt aatgatgcat gtattaatcc agataaaaca
     4921 gatgaaatat taggtgaccc aacagagggc gcattaattt ttatggccaa aaaatttgga
     4981 atagatcaag aagctcttga agaagaatat ccacgtgtat ttgaacagcc ttttgattca
     5041 gatagaaaat gtatgacaac tgttcataat atagatgaaa agattattgc ttatactaaa
     5101 ggagcagtag acgaaattct tgacctatgt actaaaatat taacttcaaa aggtgaaaga
     5161 aacattaccg aagtggataa aaagaatata cacgaattat gtcttaacat gtctaaagat
     5221 gcattgcgtg tacttggttt tgctaagcgt gagatttcat ctataccaaa agaagatagt
     5281 gaaaatatag aatatgattt aacatttata ggtatggttg gtatgattga cccaccaaga
     5341 actgaggtaa ttgatgcagt aagtacttgt aaagaagcag gtataagaac cataatgata
     5401 acaggtgacc ataaagttac tgccacaaca atcgctcatg agttaggaat atggagtgaa
     5461 gaaaatactg tgatatctgg tgatgaactt gataatttga gtgatgatga actagatgaa
     5521 gctgttaaaa atactacagt atttgctcgt gtatccccat ttgataaact tagaattata
     5581 caatctctaa aaagaattgg agaagtacca gcaatgactg gggatggtgt aaatgactct
     5641 cctgccttaa agtctgctga tattggtata gccatgggta taagtggtac agatgttgca
     5701 aaagattctt ctgacatgat tttaatggac gatagtttta caacaattgc ttatgcaata
     5761 aaagaaggta gacgtgtata tagaaacata caaaaagtta tacaattttt gcttgttggt
     5821 aatatagcag agatacttac gttgtttgta gcaatattat taaattggga tactccgctt
     5881 cttgctgttc atattctatg ggtaaacctt gcaactgcta cgcttccagc ccttgctctt
     5941 ggagttgacc caccaagcag aaatataatg aagcaccagc cagtgaaatc aaccactttg
     6001 tttgaaaaaa atcttataca aagagttgtt acccaaggta tatttgtggc aataatgact
     6061 attttagcat ataaaattgg tcttaatata gaaaatcatt ctgtaggtca aacaatggca
     6121 ttttgtgtat tagcattttc acagatgtta cgagcattta gtcagcgttc aaatacagat
     6181 tcaatgttta atagaaataa tggtaaaaat ccatttcttt taatctcatt tttaacttct
     6241 gcatttttaa tagcagtaat actatttgca cctgttttta gaaatgcttt taacttaaca
     6301 gttttaaata acttagagtg gcttataacg attgttttag ccataatgtc tgtaattcaa
     6361 gtagaggttg ggaaaattat taaaagaaaa aaattaaaaa aatagttgac aaaattagga
     6421 aaaatatata agatataaaa catagaaaaa ttaaataaat cttatccaga gaggtggagg
     6481 gactggccct atgaaacccg gcaaccagta tatttatata cagtggtgct aaatcctgcg
     6541 gcgaaagctg agagatgagt ataattaagc ttatacagag cctgagttat atactcaggc
     6601 tttatttatt ttaactctca tctggtaaat agtttaattt tttttactaa aatctaaggg
     6661 ggatacaaga atgtataata aagaaacaat atgtgtgcaa ggaaattata aaccaggtaa
     6721 tggagaacca agagtactac ctttatatca aagtacaact tttaaatata gcagtataga
     6781 ccaacttgct gaattatttg atttaaaagt tgatggacat atatattcaa gaataagcaa
     6841 tcctactatt caagcttttg aagaaaaaat aagtttacta gagggtggag tatcttctgt
     6901 agctgtatca tcagggcaat ctgcaaatat gttggcagtt ttaaatatat gtaaatcagg
     6961 agatagtata ctttgttctt caaaagtata tggaggaaca ttcaatttac taggacctag
     7021 tcttaaaaaa tttggtatag atttaatatc gtttgactta gattcaagtg aagatgagat
     7081 agtagaactt gcaaaggaaa atactaaggt tgtgtttgca gaaacacttg caaatccaac
     7141 tcttgaagtc atagattttg aaaaaatagc aaatgtagct aagagaatta atgttccatt
     7201 tattgttgat aattcattag catctccagt gctttgtaac cctttaaagt atggagcaaa
     7261 tatagttact cattctacca caaaatattt agatgggcat gcttcaagtg ttggaggaat
     7321 tatagtggat ggtggaaact ttaactggga taatggaaaa tttccagaat tagttgagcc
     7381 agacccaaca tatcatggta taagctatac tcaaaaattt ggaaatgccg catatgcaac
     7441 taaagcaaga gttcagttgc ttagagacta tggaaattgt ttaagcccat tcaatgcgta
     7501 tcttactaat ttaaatgttg aaacactaca tcttagaatg gagagacata gtgaaaatgc
     7561 acttaaaata gctagatttt tagaaaaaca tgaaaatgta gattggatta attacccagg
     7621 acttgaagat aacaagtatt atgagaatgc caaaaagtat ttatcaagag gatgtagtgg
     7681 tgttttatca tttggagtaa gaggtgggtt agaaaatgcc aaaaaatttg tggaaaaatt
     7741 acagatagca tctttggtta cacatgtttc agatgtaaga acttgtgtta tacatccagc
     7801 ttcaactact catagacaat taacagagga acaattaatt gcatctggag tattgccttc
     7861 actaataaga ttatctgttg gaatagaaaa tgtagaggat ttaatagctg atttaaatca
     7921 agctttaaat ttctaatatt ctaagagaaa gagaagtgaa aagatatggc tttaatacta
     7981 ccaaagggat tacctgttat taataaatta ttagatgaag gaatagatgt aatttataaa
     8041 gaagatttta aaaaggaatt aaagtatgaa gaaaacatag acactaagat agctatacta
     8101 aatctaatgc ctataaagat agatacagaa ttagatttac taagaaggat agataaaaca
     8161 ggattcaacg tgtctgtgga atttattaaa atttcaacaa gagaaagtaa aagaagttgt
     8221 aatgaatatg ttaaagaatt ttataaaaca tttgatgaag ccaaaggaga gtattttgat
     8281 ggctttataa taacaggagc tccagttgaa caaatggagt ttgaagaagt tgattattgg
     8341 aatgaactag aagaaattat ggattattct aagagaaaaa ctaaatctac attatatata
     8401 tgttgggcag ctcaagcaag tctttacaaa tactacaatg taaaaaaact tccactaagt
     8461 caaaaatgtt ttggagtatt taagcataag gtagataaag atagtaaaat agtagatgga
     8521 tttgaaaatg aattttttgc tccacattca agacatacta ctgtaaatat tgaagctttg
     8581 aaagagaata aagagttgag cattgtgagt cattctaaag aagctggtcc ctatataatt
     8641 acaaattcaa gagatgtgtt cgtaatgggt catagcgagt atgacaaata cactcttgat
     8701 aaagaatata agagggatat aaataaagga gataaaatat ctatacctca aaattactat
     8761 attaatgatg acccttcaga agagccaact gtaaaatgga aaaaacattc agaattgttg
     8821 tttagaaatt ggataaaaaa ctatttgata caataaattt taagagtata taaatgttaa
     8881 ctaaaaaaat atagaaattt ataggtataa agttaatctt aatgatactt tataccttat
     8941 ttttttaaaa tttgacctta taatagtagt tttatatttt aagaaaatca ctttaggtgt
     9001 atgtagatag aggtggcttt aattttatat atggtgcgat aatgggagac taaaccttta
     9061 tagtatcaat aaatttgtat tttaactttt aaaagagatt aaaaagggag aaatcagtgt
     9121 aaaatatata tagatttttt attaaatttt attaaaaata tcctgtataa aattaaatat
     9181 caataagata acaaaatttc aattgaagtt acaatattgt aattgacaat aaatacttaa
     9241 tactataata tttaatacat taaacattat agtgttaagt atttattaca gtatgcactt
     9301 cagcctaaat ttgaaataaa gtattttcgt agggagcgtt tgtatggatg agatgagttt
     9361 taagaaagag ctactagagt tgactagaga tataaatatg aaatttacaa ctttattaag
     9421 tgatttttat cagccacttg gtattacagc agtgcaagct ttgattttat ctgagttatg
     9481 tgaacatgga gagaaaaaaa taagcgattt agggaagaac ttaaacatga caaatagtaa
     9541 tgtatcagta atctgtcaaa ggcttgaaaa aaatggcttt ttaaatcgca taagagatat
     9601 agaagaccaa cgaattgtaa aagtaaaagt tacaaataaa tcattggata tacaagaaca
     9661 tatttcaagt agtatttttg atagttattt tgaaaatatg accagtgaaa aattgcaaga
     9721 tatggaagat ataatagaag gtttagagaa attaaataaa cttttaactt acattgattg
     9781 caaataacat aaaaataatt taaaggagaa taaaattatg gatgaacata aaccccaaaa
     9841 aaggtcagca ctctattatt atacagttat aataatagta gtaatgtttt taaatgcttt
     9901 aatatttcca agtttaatgg ataaaaaaat ggttgagatt gactatggaa agtttctcac
     9961 aatgttggat acaggaaagg ttaaatctgt tgagatagaa aataatagaa tagcaataaa
    10021 tccatctagt agcaaggata agaatatata cataactggt agaatggatg acccagaatt
    10081 ggtagataga ctaaaaaatg caaaagtaga atttactaag gttattccta aggaaaattc
    10141 acctctttta agtattttac ttacatggat aatacctata ggtattctta tgctatttgg
    10201 taacttaatg atgaagtcta tgcaaaagcg aatgggtggt aatgctatgc aatttggaaa
    10261 aagcaacgcc aaaatgtatg tatctgctca aagtggaaaa agatttaatg atgtagctgg
    10321 tcaagatgag gcaaaagaag ctttaactga aatagtagat ttcttacaca atccagaaaa
    10381 gtataaaaag ataggagcac aaatgcctaa aggagcactt ttagtaggac ctccaggtac
    10441 aggaaaaaca ctccttgcaa aagctgtagc aggtgaagca aatgtaccat ttttctcaat
    10501 atctggttct gagtttgttg agatgtttgt aggaatggga gcttctagga ttcgtgattt
    10561 atttaaacaa gcaaaagaaa aagctccatg tatagtgttt atagatgaga ttgatactat
    10621 tggtaaaaag cgtgataatg gaagtggatt aggtggaaat gatgaacgtg aacaaacttt
    10681 aaatcagttg ttaagtgaga tggatggttt tgatggtgga attggagtag taatacttgc
    10741 tgctacaaat agacctgaca gtcttgacaa agcattactt cgtccaggaa gatttgatag
    10801 acgtatacca gttgaacttc cagaccttgg aggacgtgaa gctatattaa aggtacatgc
    10861 tcaaaatgta aatgtaagct cagatataga ttataatgca attgcaaggt ctacatcagg
    10921 agcatcaggt gcagaacttg caaatattgt aaacgaagca gcacttttag cagttaagtc
    10981 tggcagagat atagtagaac aacaggattt tgatgaatct gttgaaactg taattgctgg
    11041 gtatcaacgt aaaggagctg taatttcaga taaggaaaag aaaattatag catatcatga
    11101 aataggtcat gcacttgttg ctgctatgca aaaacattct gcacctgtcc ataagattac
    11161 tataatacct agaacttcag gagcattggg atatactatg caagttgctg aagatgagag
    11221 tgtacttatg tctaaagaag aagcaattga taaaataact acttttacag gtggtcgtgc
    11281 tgctgaagag gttatcttta acacttgtac atcaggagca tcaaatgata tagaacaagc
    11341 tactaaaatt gcaagagcta tggttactcg ccttggtatg agtgaagagt ttgatatggt
    11401 cgctcttgaa actgtaagca atcaatattt aggaggagat acttctcttg cttgttcttc
    11461 cgacactgct gctaaaatag atgaagaggt atttaaaata gtaaaggctt gtcacaaaaa
    11521 tgcaattgaa atcttagaaa ataatattga taaattgcat gaacttgcta attatttatt
    11581 agaaaaagaa actattacag gtgatgagtt tatggaaata cttaacttaa actaaaatga
    11641 ttatacacaa gataaaaatg cctattgtta ggcattttta ttttacaact aaatttttta
    11701 aattcatatt taaatcttta cataatctta atcattaaaa atacatctta actacaattt
    11761 tatatcggaa ttgatattat aatagtaatg aatggtgtaa ggaggttttt taatggatag
    11821 acctaatcct gatattctat tagaaaaaat taaaaatgaa gaagaaaaac taagtagagg
    11881 tcaattaaaa atattctttg gttatgcagc tggagtagga aaaacctact ctatgttgga
    11941 atctgcacaa aatttaaaaa aagtgggtgt agatgtagta gttggatata ttgaaccaca
    12001 cactagacca gaaacattgg ctttacttga tggcttggaa attcttcctg taaaggagat
    12061 agaatataaa tctataaaac taaaagaatt tgatttagat gctgctttag caagaaaacc
    12121 agaagttata ttagtagatg aatttgccca ttctaatgtt gctgggttaa ggcatacaaa
    12181 aagatggcaa gatatagaag aattgctgtt agcaggcata aatgtctaca ctactgtaaa
    12241 tgtacaacat ttagaaagtc taaatgacat tgttgagata attacaaacg tatcagttaa
    12301 agagactata ccagataagt ttttggatac aaatacacag ttagaactta tagatgttga
    12361 acctgatgta cttcttgaaa ggttcaatga aggtaagata tataagaaag aacaagctac
    12421 tagagcaaaa aataattttt ttataaaaga taacctggtt gcacttagag aaatcgcact
    12481 tagaaaaact gcagagagag ttaataaaga agttcaaatg accagactat caaagggtga
    12541 tgtaactgta atacctacat cagatacact tcttgcatgt ataagtccat ctccatcttc
    12601 agcaaaagtt attagaactg catccagaat atcagacagt acatttgcaa aatggatagc
    12661 tttatatgtt gaaactccaa acacagcaag acttccattt gatgaacaaa aacaactaca
    12721 aaataaccta aaattagcta agaaattagg tggagaaata attgttttac atggtgaaaa
    12781 tataatagag caaatactta gaattgcaaa gctgagaaat gtaacaaaaa ttgtaatagg
    12841 tagaaatcat tcaagtaata aaagatttag taaaagattt aaaaaagata tagttgacaa
    12901 attaattgat gaagttgatt atatagatat acatataatt ccatataaat ttgcctcaga
    12961 tgttaaatac aaacctaaaa aggataaatc atcaataaaa tctaaattta aaattagcaa
    13021 agttgatttt ataaaactta tatttattac tttgatgata agtattttag catatgcagt
    13081 acaaagcatg ggatttataa gagaaaatat attgttaata tatatgttgg gtgtagtttt
    13141 agtttctatg tggactaaag ggtatagtac aggtataata agttctgtat ttaatatagt
    13201 tcttttaaat tattttttca cagcaccatt atatacatta tctatagcag attcaaacta
    13261 tatagtaaca ctggttgtat tctcaatagt aggtataata actagcactc ttacgtctaa
    13321 gatacagcat gaagcagaaa ctgctgctaa aagagaagaa aatacaaaaa tgatatatca
    13381 aataattaag ggatttttaa gattatcaaa taaagatgat atagtaaaca aaggtataga
    13441 acttttgtct cttagcttaa gtagagatgt aatttgttat ttaaatgtag ataagcataa
    13501 taaatcaaag ctttacaaaa aaaatactaa taataaggat aaaaatgatt tggatagtga
    13561 agatgaaaaa gctgttgcaa gttgggtttt atccaattca acagtagcag gaaatgacac
    13621 ggatacactt cctggttcaa agggatacta tataccaatt gtaggaatga atttaacttt
    13681 aggagtagtg ggaatatcat gtattgattc aaaattggat acagaagata taagcttaat
    13741 tgaaacaata attgctcaaa tggcaatagc gcttgataga gaaatcttgt cagaagctaa
    13801 agaaaatacc aatcttgaga ttgaaaggga aagattaaga agtaatcttt taagagcagt
    13861 ttcgcatgac cttagaactc cactagcagg aatatctggt gcagtaagta caattataaa
    13921 aaacaagggt actataggtc aagatataat agatgaatta cttagtggtg tatatgaaga
    13981 tactcagtgg ttaataagac ttgttgaaaa tttacttagt atgaccaaga tagatgaagg
    14041 gaaattggaa gttaaaaaac attctgaact ggttgaggaa attatatcag aagcgttaca
    14101 aaaaataaaa aaaagaattg aaaatgcact tatagatatt aatataccag aacagatatt
    14161 atttgttcct atggatgcaa aattaataga acaagtttta attaatttaa tagataattc
    14221 tttgaaatat tcaaaggaag attgtaagat agagataaat gtatatgaga aagatgatta
    14281 tgtttggttt gaagtatctg ataatggtcc tggtatatca aaggaactta aaaagcatat
    14341 ctttgacaga ttttttactg gagaagaagg agctaaagat tccagaaagg gtgttggact
    14401 tggattatca atttgtaaat ctataattca agctcataaa ggtgaaatta tggtagaaaa
    14461 caataaagat aagggttcaa cttttaagtt tagtttgcct aaggaaaatg aatagtttta
    14521 aattttaaaa ttagttttgg aggaagaaat gagtaaaaaa cttatattgt tagtagagga
    14581 tgataagaca ataagaaaat ttatatctac tgcactttta acacaggatt atgatgtcaa
    14641 ggaggctata actggaaaag aaggtatatc tatagctgtc tcatattctc cagatgttgt
    14701 tcttttagat ttaggcttag aagatatgga tggaatagag gtaataaaag ctatcagaca
    14761 attttcaaat ataccaataa ttgtagtttc agctagagag caagatagag acaaggtaga
    14821 agtatttgat gcaggggcag atgattactt aacaaaacca ttctccatag tagagttatt
    14881 agcaagagta agagtagcat ttagacattc acaagtagaa gctcaacaaa aagatgatgt
    14941 taaatctacg tttgaagtag ataaattatt gattgatttt gataaaagaa aagttattgt
    15001 tgatgatgtt gaagtccatt tgacacctat tgaatataat attctttcat tacttgcaaa
    15061 gtatcatgga aaagtgctta ctcataattt tataataaaa gaaatatggg gtagtgttat
    15121 agggaatgag actaagtctt taagggtctt tatggcaacg ttaagacgaa aaatagaaaa
    15181 acaacctgca aacccaagat atataattac agaagttggt gtaggataca gattaaatga
    15241 tgaatagttg taatatatta attattagat tatgtgctta ttaatatata ttaaaattat
    15301 atagtttagt taaaataaga atgaagtgta tgtgcttgtt gtcagtttag cacatgcatt
    15361 ttatttttta gcttttttag tatcaataat tttttagtat caa
//
LOCUS       DAEPID010000087        14906 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.087, whole genome shotgun sequence.
ACCESSION   DAEPID010000087 DAEPID010000000
VERSION     DAEPID010000087.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 14906)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 14906)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..14906
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.087"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            40..678
                     /locus_tag="KR257_003142"
     CDS             40..678
                     /locus_tag="KR257_003142"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889844.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0031813.1"
                     /translation="MSNQRKDFDITNDMFQESIPITTKIILEDMPSNDELNHVFSKGC
                     ERKMKKRKIVLITLLLIGVLLLGSILYNLFLGKTANISMLKESWNFDIPIPNKEIEVF
                     DTQDSINGDGQSYFIQGFSEKNFKKVFNLKGGIVVSKDNINEIEKYIDKFKRDSVNIN
                     KSNKNKIEEDFKKYKLEVKKDDKYIYKRNYENYVVLIIKKDEQKLYSLIWNQ"
     gene            complement(1167..2927)
                     /locus_tag="KR257_003143"
     CDS             complement(1167..2927)
                     /locus_tag="KR257_003143"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861938.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
                     /protein_id="HBH0031814.1"
                     /translation="MQEVEVIKAKNVLARQARGKAIERLRVAAYCRVSTDSEDQLNSY
                     KSQVQYYTDMIKKNKEWVLADIYADEAITGTQVTKREDFQRMINDCMNGEIDMVFTKS
                     ISRFARNTLDTLKYVRMLKERNIAVYFEDEKINTLTMDGELLLVVLSSVAQQEVENIS
                     ANVKKGLKMKMKRGELVGFQGCIGYDYHPEDKTITVNQEEAEIVRYIFNRYVDGAGGS
                     VIGQELESLGYKTKYGSSTWAPSTVIGIIKNEKYKGDILLGKTFTVDPISKRRLENMG
                     EEDKFYMKDHHEPIISEEVFEKAQEILNRRNKNRTTVGSGKREKYSRKYAFSCMLECG
                     FCGGTLTRRNWHSGSKYSKVIWQCVTATKKGKKFCKHSKGIPETAIEEAFVESYRLLC
                     DDNKDVLEEFLQRMDDTLSSSVVSKQLAKAEKEIDALEKKKSKLVDMRLEEIIDKETY
                     ESKYADLVSKQEQLVEERQKLQETSDNEKDIKKRLKEFKKTLEQNEVLDKFDRYVFES
                     IVEKVIVGGLDENGNVDPAQLTFVYKTGLKNSVDGAKFKTQRKNARGRHRTNELCSHD
                     SNEVDKMCSDSSNDTCGNCS"
     gene            complement(2990..3133)
                     /locus_tag="KR257_003144"
     CDS             complement(2990..3133)
                     /locus_tag="KR257_003144"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898594.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="conjugal transfer protein"
                     /protein_id="HBH0031815.1"
                     /translation="MNNIIRYSMQIAMLKQLLARKLISEKEYTLVKQRLMKDYKVLSD
                     ITA"
     gene            complement(3452..3691)
                     /locus_tag="KR257_003145"
     CDS             complement(3452..3691)
                     /locus_tag="KR257_003145"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002592280.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="HBH0031816.1"
                     /translation="MMKSTKKCPSFSTISSAADGNEVAIEKILNHYDAYISKASLRPF
                     YDEHGNMYIVLDMELKGRIRAALIKVILGFEVKVK"
     gene            complement(3696..4112)
                     /locus_tag="KR257_003146"
     CDS             complement(3696..4112)
                     /locus_tag="KR257_003146"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002592281.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sigma-70 family RNA polymerase sigma factor"
                     /protein_id="HBH0031817.1"
                     /translation="MKPSSFEGAIRLQFDCLARKVVGRTVKNYDRELGRRARRETPFC
                     DLSEMELNQIGAMDEYCVEFTSFDVFGSEVHIYDERLCEAIKELTESRRNILLMSYFL
                     EMTDAEIAEVMEMERFSVCRNRLHTLKLIKDMYEEE"
     gene            complement(4109..4408)
                     /locus_tag="KR257_003147"
     CDS             complement(4109..4408)
                     /locus_tag="KR257_003147"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729347.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="conjugal transfer protein"
                     /protein_id="HBH0031818.1"
                     /translation="MKHLHIQQLSTIGSSLKKHLNSTEHNAPICGFLQHITGIICLAQ
                     DQYVCIALVLFYCIKLFQKIFAVGYQIPPFMVSVSAKRGRSLFALATFAGKGVRL"
     gene            complement(5459..5626)
                     /locus_tag="KR257_003148"
     CDS             complement(5459..5626)
                     /locus_tag="KR257_003148"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002587909.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0031819.1"
                     /translation="MNWKELWMTLFGTTEWLGLNIGFWVAMAVVLLIVIVMNVVFWSM
                     KPKKDTKESYK"
     gene            complement(5639..8404)
                     /gene="mgtA"
                     /locus_tag="KR257_003149"
     CDS             complement(5639..8404)
                     /gene="mgtA"
                     /locus_tag="KR257_003149"
                     /EC_number="7.2.2.14"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002571344.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="magnesium-translocating P-type ATPase"
                     /protein_id="HBH0031820.1"
                     /translation="MNKKENRMAIRQTVEKAVIRDEQNRRIQFAATNPIKEVLKKLHT
                     TLRGLEVDEVSVSRAKYGTNKVTHEKKKSLAKRLVGAFINPFTAILFCLALVSTITDM
                     IFPYFSLFGSVPEDFDSLTVVIILTMVFISGTLRFVQESRSGNAAEKLLAMITTTCTV
                     TRRNYEKKELPMDDLVVGDIVHLSAGDMIPADVRILDAKDLFVSQASLTGESEPIEKT
                     PNVSAQKESVTDYTNIAFMGSNVISGSATAVVVCVGDHTLFGSMASAVAGEAVETSFT
                     KGVNAVSWVLIRFMLIMVPLVFFVNGITKGDWLAAFLFGVSIAVGLTPEMLPMIVTTC
                     LAKGAVSMSKKQTIVKNLNSIQNFGAIDILCTDKTGTLTQDKVVLEYHLNVNGEDDTR
                     VLRHAYLNSYFQTGYKNLMDLAIIHKTEEEEAADSRLIDLSENYVKVDEIPFDFTRRR
                     LTTVVQDNKGKTQMVTKGAVEEMLSICAFAECNGGVQPLTDDVRYRILETVDNLNDKG
                     FRVLAIAQKSNPSPIGAFGVKDECDMVLIGYLAFLDPPKESTADAIKALKDHGVITKI
                     LTGDNDKVTRTICKQVGLEVRNMLLGSDLEQMGDAELARVAESTDVFAKLTPDQKARV
                     VSVLRENGHTVGFMGDGINDAAAMKAADIGISVDTAVDVAKESADIILLEKDLMVLEQ
                     GIIEGRKTYANMIKYIKMTASSNFGNMFSVLAASALLPFLPMMSVHLIFLNLIYDLSC
                     TAIPWDNVDEEFITKPRKWDASSVGSFMIWIGPTSSIFDFTTYIFMYFVFCPLFVSNG
                     VLFNDLPAHFSGAELAMLQAQYIGMFQAGWFVESMWSQTLVIHMIRTPKLPFVQSRAS
                     APVTLLTMTGIIVLTIIPFTVFGTMLGFVALPAAYFAYLIPCILLYMTLATSLKKAYV
                     RHFGELL"
     gene            complement(8570..8881)
                     /locus_tag="KR257_003150"
     CDS             complement(8570..8881)
                     /locus_tag="KR257_003150"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003417391.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3784 domain-containing protein"
                     /protein_id="HBH0031821.1"
                     /translation="MDFTCIFFGILFTLAGFWLAFGKGYRHLSLWKNMPQEEKDKINI
                     VPLCRNVGEMIALNGIIFLMKGFLPGFSNHWFVFAIIAWLIVAGFDVWYIEKSVRYRN
                     Q"
     gene            complement(9128..9805)
                     /locus_tag="KR257_003151"
     CDS             complement(9128..9805)
                     /locus_tag="KR257_003151"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018597221.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MgtC/SapB family protein"
                     /protein_id="HBH0031822.1"
                     /translation="MFYTDFILRIALSLTLGFLIGLERQLTGHPAGIRINVLICMGTS
                     FFTLFPMLYGSDQVFRVGSSIISGVGFLCSGVIFKDRGTVRGMNTAATLWCTAAIGIL
                     ASTGMYAMAITAATILIGSNLILRPFARKFHPITSSDESEKQYRISVTCQEKAEQDIR
                     LLLINSNSCKTLFLNNLESGDVVGDKVEIVAEYCSVGKSKNNILEGIVGQVLVIPEVI
                     SAGWEVL"
     gene            complement(9943..10446)
                     /locus_tag="KR257_003152"
     CDS             complement(9943..10446)
                     /locus_tag="KR257_003152"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006566797.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="winged helix-turn-helix transcriptional
                     regulator"
                     /protein_id="HBH0031823.1"
                     /translation="MKKNISYIPMDSALEIWLLEKLLRDPPDSDCAKDLLSGIQEMIR
                     GEVSSLLLGASEESDWPVGTLSDRILAGDLEIYPRGRKVLIKGSEVNLTPKEFDILYF
                     LVQNKGEVFTKEQIYRAVWEEDYILDNSNIMAFIRKLRKKIEPAPDCPTYILTIWGIG
                     YKFNDQI"
     gene            complement(10462..13125)
                     /gene="mgtA"
                     /locus_tag="KR257_003153"
     CDS             complement(10462..13125)
                     /gene="mgtA"
                     /locus_tag="KR257_003153"
                     /EC_number="7.2.2.14"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016440611.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="magnesium-translocating P-type ATPase"
                     /protein_id="HBH0031824.1"
                     /translation="MSKATLFDSRIKKYAYCRTSEIYRDIGSSPDGLSIEQIGSMREK
                     YGANSFNGRKNDTTMQRLRRAFINPFHVILFVLGIVSLVTDVFVASNFARNATTAIII
                     FSMIVISGVIRLIQELRAKSAAAQLDRLVHESVTVRRDGKLIEIPGEELVVGDIVLFS
                     AGDRVPADIRLTKITDLFISQAAITGESAIIEKSCRKLSYGEQDTLTQLENLAFMATT
                     VISGKGEGIVLAVGKDTLYGGFTKPDSDDKNSFKKGADSIAWVMIRFMAILVPIVFIL
                     LGITDGKWMESFAFALSVAVGLMPEMLPMVITACLAKGSLAMSKKQTIIKDINAMQSF
                     GSMDVLCMDKTGTLTNESILLEYYMDIFGNENAEVLDLAYLNSCYHSGVCNTIDNAIL
                     ACNTMPGREAHYANLLTKFQKADEIPFDYARKFVSTLVQDSNGNSQLIMKGDIEHIFS
                     RCNHVEYRGKLLPMGQDARQSVSSVVGEMLQDGMKVIAVARKNVGAQKKITPDDEWGM
                     TLVGYLSFFDAPKQTAKESVTALKRLKVIPKILTGDQAAIAVSVCRRVGIYTERILTG
                     TQLDEMTDCELKKAVEHTHVFAELTPGHKVRLVSAMQDNGHSVGFLGDGVNDIPALNE
                     ANVGISVDTAVDAAKDAADVVLLQKDLNVLEQGVMEGRKTFTNMLKYIKITASSNFGN
                     IFSIICASAFLPFLPMTSIQILLLNLLYDTLCIVLPWDNVDEEEMLSPRDWSGKTLRQ
                     FMLSFGPISSLFDIVTFLFLYYFLCPMLCGGATYLQLTDPSLQLQYVALFQTGWFLES
                     MWTQVLILHFLRTSKIPFFQSRASAPVISITLVGIIAFTSLTFVGGASLFGLTKLPLW
                     YFVFLLLVVSLYMLLNSVAKYFYKKKYQELI"
     gene            complement(13218..13427)
                     /locus_tag="KR257_003154"
     CDS             complement(13218..13427)
                     /locus_tag="KR257_003154"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898612.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0031825.1"
                     /translation="MVKVKTKKKFVSTHMCQGEMPIYVRERYEKMLAVSIRAPNLEGM
                     VENFDKDLSRPNETDLIELKNAISK"
     gene            13377..13712
                     /locus_tag="KR257_003155"
     CDS             13377..13712
                     /locus_tag="KR257_003155"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729345.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0031826.1"
                     /translation="MTHMSADKLLLGFHLDHVSNLNELLRKVAHNNICIMSDRMTKVA
                     VWKPSVKTIQLVCMEYLNYIIDHSVIYEKIQCANWNGTEETNSIFNNSPSPLITLIYS
                     CDLQQNKTT"
     gene            complement(13911..14813)
                     /locus_tag="KR257_003156"
     CDS             complement(13911..14813)
                     /locus_tag="KR257_003156"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860758.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="conjugal transfer protein"
                     /protein_id="HBH0031827.1"
                     /translation="MFKKNKKQTENVKEKKVRTVKVGTHKKTVIALWVVLIASVSFGV
                     YKNFTAIDQHTTHEKEVIELRLQDTNGIENFVKNFAKSYYTWSNSKEAIDARTQAISG
                     YLTKELQDLNMDTIRTDIPTSSAITDVIVWSIEQSGTDTFSATYEVDQQIKEGEQTTA
                     VKATYTVKVHVDAGGNMVIIQNPTLAPAIEKSDYEPKTPEADASVDADTINDATAFLE
                     TFFKLYPTATEKELAYYVSGNVLESIGRDYLYSELVNPIFTVDGDNVKVKVAVKFIDN
                     QTKATQVSQFELVLHKESNWKIIG"
BASE COUNT         4685 a         3188 c         2430 g         4603 t
ORIGIN      
        1 actagaaaaa atcaaaagaa atattagaag aaatggatat tgagtaatca aagaaaagat
       61 tttgatatta caaatgatat gtttcaagaa agcattccta tcacaacaaa aattattctt
      121 gaagacatgc cttcaaatga tgaattaaat catgtttttt caaaaggttg tgaacgaaaa
      181 atgaaaaaga gaaaaattgt attaatcaca ctactattaa taggtgtttt gttattagga
      241 agtatcctat ataatctttt tttaggaaaa acagctaata tttcaatgct aaaggaatct
      301 tggaattttg atataccaat acctaacaaa gaaattgaag tatttgatac tcaagatagt
      361 attaatggag atggacaaag ttattttatt caaggatttt ctgaaaaaaa tttcaaaaaa
      421 gtttttaatt taaaaggtgg tatagttgta agcaaagata atattaatga aatagaaaaa
      481 tatattgata aatttaaaag agattctgtt aacattaata aaagtaataa aaataaaatt
      541 gaagaagatt ttaaaaaata taagttagaa gttaaaaaag atgataagta tatatataag
      601 agaaattatg agaactacgt agttttaatt ataaaaaaag atgaacaaaa attatacagt
      661 ttaatatgga atcagtaggt acatatgtat tattaagaat tataaataat aaaaataaat
      721 tttagtcaat atacaaaaac cttttaaatt gtctggaaat cacctcttca tttgttataa
      781 aaacatacaa caaatgaaga ggtgatttta tggttttaaa aaaaataatt ataagtggat
      841 atgtgctttc acatgtttat caacatttgt aatgcctata tttgctaatg aattataaaa
      901 atattaaata atattcaact atagattatg taaattactc tatgaaaaaa atgagttgta
      961 taaaatctgg ctactgtaga ttgactattt cttttaaaat tacaattata ataagtttta
     1021 tagaattaaa aataaaactt tagagatttt tgataacatt gtagactaaa tttgccaccg
     1081 aaatcgcttt acagtggcaa atcggtggca aatacaatat attattagta tataatctat
     1141 ataaacatta ctattgtttg attatcttag ctacagtttc cacatgtgtc gttactacta
     1201 tcggaacaca ttttatcaac ctcgttgctg tcatgtgaac acaattcatt agtcctatgc
     1261 cgtcctcttg catttttcct ttgtgtttta aatttagcac catctacgct attcttcaag
     1321 cctgttttat aaacaaaggt caactgtgca gggtcaacat ttccgttttc atcaagtcca
     1381 cctacaatta ctttttcaac aatgctttca aacacatagc ggtcaaattt atcaagaacc
     1441 tcattctgtt ccagagtttt cttaaactct ttcaaacgtt tttttatgtc tttctcatta
     1501 tcagaagttt cttgtaactt ttgtctttct tcaacaagct gttcttgttt acttactaaa
     1561 tcagcatatt tactttcgta ggtttcctta tcaataattt cttccagacg catatccaca
     1621 agtttacttt ttttcttctc taatgcgtct atctcctttt ccgcttttgc aagttgtttt
     1681 gacaccacac tactactaag agtatcgtcc attctctgca aaaattcttc cagaacatct
     1741 ttattatcat cacataataa acgataactt tctacaaatg cttcttcaat agctgtttct
     1801 ggaatacctt tgctatgttt acaaaatttc tttcctttct tcgtagccgt tacacattgc
     1861 catataacct tgctgtattt tgagccactg tgccaattac gtcttgttaa agtaccacca
     1921 caaaagccac attctagcat acagctaaat gcgtatttcc tgctatactt ctcacgctta
     1981 ccgctgccta ccgttgttcg gttcttattt ctccgattaa gaatttcctg tgctttttca
     2041 aaaacttctt cactaataat cggctcatgg tgatctttca tataaaattt atcttcttca
     2101 cccatgtttt caaggcgacg tttggaaatc ggatcaacag taaaagtttt gcctaagagt
     2161 atatcaccct tgtatttctc attcttaata attccaataa ccgtagatgg tgcccatgtg
     2221 gaactcccat acttcgtttt ataacctaga ctttcaagct cctgtccaat aacagaacca
     2281 ccagcaccat caacataacg gttgaaaata tatctgacaa tctctgcttc ttcttgattt
     2341 acagttattg tcttatcctc tgggtgataa tcatatccaa tacaaccttg aaaacctacc
     2401 agctcgccgc gcttcatttt cattttcaac ccttttttta cattggctga aatgttctcg
     2461 acttcctgct gtgcaacaga actaagaaca acaagcaata actctccatc cattgtaagt
     2521 gtattgattt tttcatcttc aaaataaacg gcgatatttc tctcttttag catacgaaca
     2581 tatttcaatg tgtctaaagt atttctggca aatcttgata tggattttgt aaataccatg
     2641 tcaatttcac cattcataca gtcatttatc atacgctgaa aatcttctcg ttttgttact
     2701 tgtgtccccg taattgcttc atcagcataa atgtcagcta acacccattc cttgtttttc
     2761 ttaatcatgt cagtataata ctgaacttgt gatttataac tgtttaactg atcttcgcta
     2821 tctgtactta cacggcaata tgcagctaca cgcaaacgct caatggcttt tccacgggct
     2881 tgtcttgcca aaacattttt tgcttttatt acttcaactt cctgcatagt acacctcctt
     2941 attttgtgtt cctttcatat tgttattgta ctactttaaa aaacacaatt caagcagtta
     3001 tgtcagaaag caccttatag tctttcatca gcctttgttt tacaagagtg tattcttttt
     3061 cagaaatcag tttacgggca agcagttgtt ttaacatagc aatttgcata ctatacctaa
     3121 ttatattatt cattaaaacc ctccttgctt ttttatttat ggaagtaatc agacggcttc
     3181 ggcagctcca ctggactttc accattccca ttctgatggg tgaaccgtgt catacgggtg
     3241 tatcattatt cagatatacg agtcatggca gcaacctttc caaagatcgc ttgcggttca
     3301 ctggcataat cgctcgctgc tttccccatt tcagtggtcg tggcgttcca gtccgctggc
     3361 tcgtcgtata tcaaacgtat ctgattactg tattcacttg tcaaagaacg gaaaagagtt
     3421 aaaatgaggt ggtagatact ctctgttata tttacttcac tttgacttca aaccctaaga
     3481 ttactttaat caacgctgcc cgtatcctgc ctttcagttc catatcaagc acgatataca
     3541 tattcccgtg ttcgtcatag aacgggcgta ggctggcttt tgatatgtaa gcgtcataat
     3601 ggttcaaaat cttttcaatt gccacctcgt taccgtcagc tgcagaactg atggtcgaga
     3661 atgatggaca cttttttgta gacttcatca tgtttttatt cctcctcgta catatcctta
     3721 ataagcttta atgtgtgcag cctgtttcta catacggaaa atcgttccat ttccataacc
     3781 tctgcaattt cagcgtcggt catttcaaga aagtaggaca taagcagaat gttacgtcgg
     3841 ctttctgtta attctttgat agcttcacat aagcgttcat catagatatg gacttctgaa
     3901 ccaaatacat caaatgacgt aaactcaacg caatattcgt ccatggcacc gatctggttt
     3961 aactccattt cagataaatc acagaacggc gtttcacgtc ttgcacgtct gccaagctct
     4021 cggtcatagt tctttacagt tcgtcctaca accttgcgag ctagacaatc aaattgaagt
     4081 ctgatagcgc cctcgaaaga agatggtttc ataatctcac cccctttcca gcgaaagttg
     4141 ctaaagcgaa aagacttcta cctcttttcg cactaacact caccatgaaa ggtgggattt
     4201 gatacccaac cgcaaaaatt ttttgaaaaa gttttatgca gtaaaaaagc acaagggcaa
     4261 tacagacgta ctgatcttgt gctaaacaaa ttattcctgt tatatgctgt aaaaaaccac
     4321 atataggagc attatgttcc gtagaattta aatgtttttt taatgaacta ccgatggtcg
     4381 aaagttgttg aatatgtaag tgtttcatac ggctacccct agagccgata aaacaagacc
     4441 atccagtaat ttgtccaacg ttaggcaaaa ataaaacggc ggctatataa ccgtcgtctt
     4501 attcaaaagt tcaaaaagaa ctaaactaaa ccctctaaag cagtatgtat ttataatcag
     4561 tcttgcaaaa taacaaagta gaattgaaat ataaggtagc aatccttgtg catctaataa
     4621 acttataggg gttacagcag accacggaat aatattttgt atactttcag atcaatatag
     4681 tccaacaaaa ccaattcccg atatttagta actaaaaagt aaactagagt agaaaacatt
     4741 tctttgcaaa acacaaataa taagtaatgg actcattgac aatagattga gaaatccagt
     4801 tttttagact tagatagatt atctcacttg taaatgattt aagttctttg acttcatata
     4861 tagcggtata atctgtcaac gtgatcatta caaaccataa tgcctatata acatactttc
     4921 caagcaaaaa ctttattcta ttagttgggg aatacaaaat atttatcatt gtgcgttcaa
     4981 catattcttt ttgtataaaa atgtaattac aaaacaccac tcaatataag atagataata
     5041 atttgaatag gaattatcaa tctacgtaac cattcattac ctgtcattgt tgttacaata
     5101 gatttgggat tctgtttcca ttacataatt tttttatcct tctttcagat atctcctcat
     5161 tttatcgaag cttcttctac agacatacat tccataataa aatctacctt tgaatattat
     5221 ttcacgattt cgttatagac gcgtaaacaa acaataaaaa acgaaatttc ttttaagtac
     5281 cataattttt atatcgaaat tacaattatc cacttatata cagcatttat aggtaattca
     5341 atgataaaaa aacacatact ttactactaa attgccacaa ttgaatgcgc cttgatatga
     5401 tagggagatt ccacaataaa aaactgtgca tctcccttga ttcattcata ctgatatctt
     5461 atttataaga ctcttttgtg tctttttttg gtttcatgga ccaaaatact acattcatta
     5521 caataacaat cagcaacaca actgccatag ccacccaaaa gccgatatta agaccaagcc
     5581 attcggtagt tccaaaaagg gtcatccaaa gttctttcca gttcatcatt ccacctcctt
     5641 aaagcagttc tccgaaatga cggacatagg ctttttttaa acttgttgcc aaagtcatat
     5701 acagcagaat acatggaatc agataagcaa agtatgctgc aggcaatgca acaaatccaa
     5761 gcatagttcc aaacacagta aacggaataa tggtcagaac tataattcca gtcattgtta
     5821 gcaaagtcac cggagctgat gcacgactct gaacaaaagg tagctttgga gtacgaatca
     5881 tgtgaatgac taatgtctgg ctccacatag attccacgaa ccaccctgct tggaacatcc
     5941 cgatatactg tgcctgaagc attgccagtt ctgcaccgct gaaatgagca ggcaaatcat
     6001 taaataatac accattcgat acgaacaatg gacaaaatac aaagtacata aaaatatagg
     6061 ttgtaaaatc aaagatagaa ctggttggtc caatccagat cataaaactt ccaacactgg
     6121 aagcgtccca tttacgaggt ttggtaataa actcctcatc cacattatcc caaggaattg
     6181 cagtacagga taaatcataa attaagttta gaaatataag atgaacactc atcattggta
     6241 agaaaggtag caaagcagat gcagcaagca ctgagaacat attgccgaag ttggatgaag
     6301 cagtcatttt aatgtacttg atcatgttgg catatgtctt tcgtccctca ataataccct
     6361 gttccaaaac catcagatct ttttccaata gaataatgtc agcagattct tttgccacgt
     6421 ccacggcggt atccaccgaa ataccaatat cggcggcttt catagctgca gcatcattaa
     6481 taccgtcacc catgaaaccg accgtatgac cattttcacg gagaacagaa accacacggg
     6541 ctttctgatc aggggttagc tttgcaaata catctgtaga ctctgccact cttgcaagct
     6601 ctgcatcgcc catttgttcc aaatcagaac cgagaagcat attgcgaacc tctaatccca
     6661 cctgcttgca gatagttcga gtcactttgt cgttgtcacc tgtcaaaatt ttggttataa
     6721 caccatggtc tttcagagct ttaatagcat ccgcagtaga ttcttttgga ggatcaagga
     6781 atgccagata tccaatcagt accatatcac actcatcttt aacaccaaat gcgccgattg
     6841 gggaaggatt actcttctgt gcaatagcta gtacgcggaa tcccttatcg ttaagattgt
     6901 ccactgtctc cagaattctg taacgaacgt catcagtcag aggctgcact cctccattac
     6961 actctgcaaa cgcacaaata gagagcattt cttccacagc accttttgtt accatctggg
     7021 tcttaccctt attatcctgt accactgtag tcagacgacg acgtgtgaag tcaaaaggaa
     7081 tctcatctac tttcacatag ttttcagaca ggtcaatgag acgcgaatct gcggcttcct
     7141 cttcctccgt cttatggata attgccaaat ccatcaggtt tttatagcca gtctggaagt
     7201 aactattgag gtaagcgtga cgcagtactc gcgtatcgtc ctcgccattt acattcagat
     7261 ggtattccag cacaacctta tcctgggtca gcgtgccagt cttgtcagta cagagaatat
     7321 caatagcacc gaagttctga atggaattga ggtttttaac gattgtctgc ttcttgctca
     7381 tggaaacagc gcctttcgca agacaggttg ttacaatcat cggcaacatt tctggtgtca
     7441 aaccaacagc aatagaaacg ccgaataaga aggccgccaa ccaatcgccc ttggtgatac
     7501 cattgacaaa gaacaccagc ggaaccataa tgagcataaa acgaatcaat acccaagaaa
     7561 cggcattgac acccttggta aagcttgttt caaccgcttc tccagcaact gcggacgcca
     7621 tagagccaaa cagagtatga tcgccaacac aaacaacaac agctgttgcg ctaccagaaa
     7681 ttacattact ccccataaaa gcaatgtttg tgtaatcagt cacgctttct ttctgagcac
     7741 ttacattggg tgttttttca ataggttcac tctcaccagt aagacttgcc tgactgacaa
     7801 acaaatcctt cgcatccaaa atacgaacat ccgccggaat catatctcca gcagaaagat
     7861 gcacaatatc tcccaccacc aaatcatcca taggaagttc ttttttttca tagtttctac
     7921 gagtaactgt acaagtggtc gtaatcatgg ctaacaattt ctctgctgca tttccgcttc
     7981 tggattcctg tacaaaacga agcgtaccgg aaatgaatac cattgttaaa atgattacaa
     8041 cagtcaggga atcaaagtcc tctggcacac tgccaaacag agaaaaatac ggaaaaatca
     8101 tatctgtaat tgtggatact aaagccagac aaaataaaat ggcggtaaat ggattgataa
     8161 atgcgccaac cagtcgtttt gccagagatt tctttttttc atgagtgact ttattggtac
     8221 catatttagc acgacttacg gatacttcat ctacttctaa gccacgaagt gtggtatgaa
     8281 gtttttttaa aacttcttta ataggattgg ttgccgcaaa ttgaatgcgg cggttctgtt
     8341 cgtcacggat gactgctttt tctacagtct gacgaatagc catacgattt tcttttttgt
     8401 tcattggtct tacctccttg aattttcata ggggcaagga atattatatg agcgacacgg
     8461 aatctccaaa ttctcatata atattctctg ccttcgtgga ctgacatcag agtccatgtc
     8521 tttcacctca caatcttaaa aaaatatcta tgtgaaacct caatgtggat tattggttgc
     8581 gatagcggac acttttttcg atataccaga catcaaagcc ggcaacaatc agccatgcga
     8641 ttattgcaaa tacaaaccag tggtttgaaa atcccggcaa aaatcctttc attaagaata
     8701 taatcccatt taacgcaatc atttctccaa cattacgaca aagcgggaca atattaattt
     8761 tatctttctc ctcctgcggc atatttttcc acagggaaag atgacgatat ccttttccaa
     8821 aggccaacca aaagcctgca agagtaaata aaattccaaa aaagatacat gtaaaatcca
     8881 tcgtttgttc ctcctttcaa tgcttaaacc tgtttcttag ttttgtcagc ttcagaagtt
     8941 taatgaagag cacaataata gtaacagcaa gaataaacca gatcacaata ctcacctgat
     9001 accatatctt aaagattacc attctttgtt caaagaaatt ccaacccaaa tagctacata
     9061 agattgtaaa tacagggtag aaagcaaaaa gaattgctcg tttcaaatct tcgatttctc
     9121 tcctcactca caacacctcc caaccagcac taatcacttc cggaattacc aatacctgcc
     9181 caacgattcc ttctaaaata ttgtttttgg attttccgac agaacagtat tctgcgacaa
     9241 tctcaacctt gtcaccaacc acatcaccgc tttccagatt gttcaaaaag agcgtcttac
     9301 aggaattgct gttaatcagc aataagcgta tatcctgctc tgccttttcc tgacatgtaa
     9361 ccgaaatacg atactgcttt tcagattcat cactggaagt aattgggtga aactttcttg
     9421 caaagggacg tagaatcagg ttggaaccaa ttaaaatagt agcggcggtg atcgccattg
     9481 catacattcc cgtacttgca agaattccaa tcgctgcagt acaccataag gtggcagcgg
     9541 tattcattcc acgtactgtc cctctgtcct tgaaaataac accactgcat aaaaaaccaa
     9601 caccggatat aatactgctt ccgacacgga atacctgatc cgaaccgtag agcataggaa
     9661 acaaggtaaa gaaacttgta cccatgcaga ttaacacatt gatacgaata cctgcaggat
     9721 gaccagtcaa ttgccgttct aatccaataa gaaatccaag tgttaaggag agggcaattc
     9781 tcaaaataaa atctgtgtaa aacatatgaa acacctccct ttaactacta acagtatata
     9841 aaaaatccaa atacaatcct atggctaaag tcttgcgatt ttcttgcgat ttggtaagaa
     9901 aatagacgga ctgaaaccga aaatggtctt agtccgtctt tgtcatatct gatcattaaa
     9961 tttgtatcca ataccccaga tggtcaaaat atatgtggga caatccggag caggttcaat
    10021 cttttttcgc aacttccgga taaaagccat aatgttgctg ttatccagaa tataatcttc
    10081 ctcccatacg gcacgataaa tctgttcctt tgtaaaaact tcacctttgt tctggacaag
    10141 aaagtacaaa atatcaaatt cctttggagt caggttgact tcagaacctt ttatcagtac
    10201 ttttctgcct cttggataaa tttccagatc ccctgccagg attctatctg acagagtacc
    10261 cactggccaa tcgctttctt ctgatgctcc taacaataac gaagatacct ctccacgaat
    10321 catctcctga ataccagaaa gtaaatcctt cgcacaatca ctgtccggtg gatctcttag
    10381 tagtttttct aatagccaga tttcaagagc cgaatccatc ggaatataac taatattctt
    10441 tttcatcatg aatgcctcct cttaaatcaa ctcttgatat tttttcttat aaaaatattt
    10501 ggctactgaa ttcagcagca tatagagaga taccaccagc agtaaaaata cgaaatacca
    10561 aagaggtaat ttcgtcagtc caaacaacga cgcaccgccg acaaatgtaa gggaagtaaa
    10621 agcaataatc cccactagag ttatagaaat gaccggtgca gatgccctgc tctggaaaaa
    10681 aggaatcttg gaagttcgca gaaaatgtaa aatcaaaacc tgtgtccaca tagattccaa
    10741 aaaccatcca gtctgaaaca gtgctacata ctgaagttgc agggaaggat ctgtaagctg
    10801 cagataggtt gcccctccac atagcatcgg acataggaaa taatacaaaa ataggaaggt
    10861 gacaatatca aacagagaac tgatcggtcc gaaagacagc ataaactgtc tcagtgtttt
    10921 gccggaccag tctcttgggg acagcatctc ttcctcatct acattgtccc aaggaagcac
    10981 aatacacaac gtatcataca gcagattcaa aagcagaatc tgaattgaag tcataggcag
    11041 gaacggtaaa aaggcactgg cacaaatgat ggaaaaaata tttccaaagt tagagctagc
    11101 ggtgatttta atatatttca gcatattggt aaaagttttt cgcccctcca ttacaccttg
    11161 ctccaaaaca ttcaagtcct tttgcagcaa aaccacatcg gcagcatctt ttgctgcgtc
    11221 cactgccgta tctacagaga ttcccacatt tgcttcattc agtgccggaa tgtcgttgac
    11281 tccatcacca agaaatccca cggaatgacc attatcctgc atagcagaga caagacgcac
    11341 cttatgtccc ggagtaagct ctgcaaaaac atgagtatgt tccacagcct ttttaagttc
    11401 acagtctgtc atttcatcca gttgagtacc agttaagata cgctctgtat aaatacccac
    11461 ccggcggcaa acagacacag caatcgctgc ctggtcccct gtcagaatct tagggataac
    11521 ttttaatctt ttgagtgcag ttacagactc ctttgctgtc tgctttggtg catcaaagaa
    11581 ggatagatag ccaactagag tcatgcccca ttcgtcatca ggagttattt tcttttgcgc
    11641 tcccacattt tttcgtgcca ccgcaatgac cttcattccg tcctgtaaca tttcacctac
    11701 tacagaagat acactctgtc tcgcatcctg ccccatgggg agaagttttc cacgatattc
    11761 tacatggttg cagcgtgaga atatatgttc aatatcacct ttcataataa gctgactatt
    11821 cccattgcta tcctgtacaa gtgtactgac aaacttacga gcatagtcaa agggaatttc
    11881 atcagctttt tggaattttg tcagaagatt tgcgtaatgg gcttcccgcc ctggcatggt
    11941 attgcaggca agaatggcat tatcaatggt attgcagaca ccagaatgat agcagctatt
    12001 cagataagca agatcaagaa cctctgcatt ttcattccca aaaatatcca tataatattc
    12061 cagcaggatg ctttcattgg taagtgttcc tgttttatcc atacaaagca catccatgct
    12121 accaaagctc tgcatggcat taatatcctt gataatggtc tgctttttgc tcatagcaag
    12181 acttcctttg gcaaggcagg ctgtaataac cataggaagc atttccggca tcagacctac
    12241 agcaactgac agggcgaaag caaaagattc catccatttt ccatcagtaa tccccagtaa
    12301 tataaataca atgggaacta atatcgccat aaaacgtatc atcacccagg cgatggaatc
    12361 ggctcctttt ttaaaggaat ttttatcatc agaatccggt ttggtaaatc ctccatacag
    12421 ggtatctttg cctactgcca gtacaatgcc ttcccctttt ccactgatga ctgtggttgc
    12481 cataaaagcg aggttttcaa gctgagtcag tgtatcctgc tctccgtaac tgagttttcg
    12541 gcagctcttt tcaatgatgg cgctctcgcc agtaatcgca gcctgagaga taaagagatc
    12601 cgtaatcttc gtcaatctga tatccgccgg aacacgatca cctgcagaga atagtacaat
    12661 atcccctacc actaattctt cgccaggaat ctctattaac tttccatcac gcctcactgt
    12721 gacgctttca tgaactaggc gatcaagctg agcagcagcg ctctttgctc gcagctcctg
    12781 aatcagacga attacgccac taattacgat catggaaaag atgataatgg cggtagtagc
    12841 atttctcgca aaattggatg ctacgaaaac atccgtaaca agagaaacaa tgcccagaac
    12901 aaaaagaatc acatgaaacg ggttaataaa tgcccgtctc aaccgttgca tcgtcgtatc
    12961 atttttccgc ccattgaagc tgttcgctcc gtatttctcc cgcattgaac cgatttgctc
    13021 aatggataaa ccatccggag atgagccaat gtctcgataa atttctgatg ttctacagta
    13081 tgcgtatttt ttgatacgac tatcaaatag tgttgctttt gacacgaaac atcccctcct
    13141 ttataagtat aagtaataac attttaacac agtgttctga aaatgctata tttatattct
    13201 tgcttttttc ttgcaattta ctttgatatg gcatttttca gctcgatcaa atccgtctcg
    13261 ttagggcgag ataaatcctt atcaaagttt tcaaccattc cttctaaatt tggagcacgg
    13321 atggatacgg caagcatttt ctcatagcgc tctcgcacat aaataggcat ttccccttga
    13381 cacatatgag tgctgacaaa cttcttcttg gttttcacct tgaccatgta tcaaatttaa
    13441 atgaactact tagaaaagtt gctcataata atatttgtat tatgagtgat agaatgacaa
    13501 aagtggcagt atggaaaccg agtgtaaaaa caatacaatt agtttgtatg gaatatctga
    13561 actacataat tgaccactct gtaatttatg aaaaaataca atgcgcaaat tggaacggga
    13621 cagaagaaac caatagtatt tttaataatt ccccttcacc attgattact cttatctatt
    13681 cttgcgattt acaacaaaat aaaacaacat aaattttaaa tacgttgact ggcataattc
    13741 atatgtatag taagtctaca attaagatgc gctttttcta atccaaatat attaagaaaa
    13801 aagttttgcg aagccattaa tactttgttt aagatgtctt tcataaatat aaagaataat
    13861 gctcttaaca aaagcgtgca aattcctaaa gaaatgcacg ctttcaataa ttatcctata
    13921 atcttccaat tgctctcctt atgtagcact aattcaaact gcgatacctg tgttgccttt
    13981 gtctgattat caatgaattt cacggcaacc ttgactttca cattgtcccc atcaaccgta
    14041 aagatagggt ttaccaattc agaatagagg tagtccctgc cgatagactc aagcacattt
    14101 ccagacacat agtaagcaag ctccttttct gtggctgttg ggtatagctt aaagaaagtt
    14161 tccagaaatg cagtagcgtc atttatggta tccgcgtcta cacttgcgtc tgcttctggt
    14221 gtctttggtt catagtctga tttctcgatt gctggtgcaa gggtagggtt ctgaataatt
    14281 accatattcc cgccagcgtc cacatgaact tttacggtat aggttgcctt aaccgctgtt
    14341 gtctgttccc cctcttttat ctgctgatct acttcgtagg tagcggaaaa agtgtccgtt
    14401 ccagactgtt caatgctcca tacaatcaca tctgtaatgg cagagctggt cggtatatcc
    14461 gttctaatgg tatccatatt caagtcctgc aattcctttg tcagataacc gctgattgcc
    14521 tgcgtccttg cgtcaatcgc ttctttgctg ttactccatg tgtaatagga ctttgcaaaa
    14581 ttcttcacga aattttctat cccgttggtg tcctgcaagc gaagctcaat cacttctttt
    14641 tcatgggtcg tgtgctggtc aatagcggta aaattcttat atactccaaa gctcacgctt
    14701 gcaataagca ccacccacaa tgcaatcacg gttttcttat gtgtgcctac cttgacagta
    14761 cgtacctttt tttctttgac attttctgtc tgtttcttat tcttcttaaa catatttttc
    14821 aagtcctttc tattgtttta ctcgtcctgc accgattaag tgctgttgcc agtaactact
    14881 acttaggtct gtatatccta tcgggt
//
LOCUS       DAEPID010000088        14851 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.088, whole genome shotgun sequence.
ACCESSION   DAEPID010000088 DAEPID010000000
VERSION     DAEPID010000088.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 14851)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 14851)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..14851
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.088"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            470..1120
                     /locus_tag="KR257_003157"
     CDS             470..1120
                     /locus_tag="KR257_003157"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421209.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="class II aldolase/adducin family protein"
                     /protein_id="HBH0031828.1"
                     /translation="MLLEKLRKEVLQASLDLLNYNLVTLTGGNVSGRDEQTGYIAITP
                     SGMDYRNLTPSDIVIVDVDGNIIDGKWKASVDLSDHLYIYKHREDINSIIHTHSTYSS
                     CFAILNEPIECASTTLANEVGGSVPVAKFSPPTSKKMGKCVIEAIGDKRACLLANHGV
                     IAVGPSVGHALTAAVMLEDSAKVYYLAKSIGTPVLLPDEEIQRARDVFFNVYGQDK"
     gene            1294..2226
                     /locus_tag="KR257_003158"
     CDS             1294..2226
                     /locus_tag="KR257_003158"
                     /EC_number="6.3.1.20"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421208.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="lipoate--protein ligase"
                     /protein_id="HBH0031829.1"
                     /translation="MYYLLNKSTNPYFNLALEEYLFLNDKYNDDIIIIWRNEESIFIG
                     KNQNPYQEVYHDVIEKGEIPILRRISGGGTVYHDLGNINMSFIQKDRQLHEIDFLEHT
                     KFMQKMLSTLGLDVSITERKDLFLNGKKISGSAQSIKRKNSLYHGTLLYDSDLNKLTK
                     YLNSNKATESNATKSVSSKVTNIKFLLEKDINYFLDYCVEYLKSNIKNIKELELDEED
                     IKSVYNIGEDKYKKIEWTYGKTPKFQVVLPFNNESKINIHVNRWKVSKFFISYDDNVI
                     NMDKLLDLNFFKEEIKESILENYPHYIDLINLIF"
     gene            2500..3213
                     /gene="ispD"
                     /locus_tag="KR257_003159"
     CDS             2500..3213
                     /gene="ispD"
                     /locus_tag="KR257_003159"
                     /EC_number="2.7.7.60"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009904750.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="2-C-methyl-D-erythritol 4-phosphate
                     cytidylyltransferase"
                     /protein_id="HBH0031830.1"
                     /translation="MYSVIIVAAGSGRRMNLDINKQFIKLREKEIIAHTIQVFYENIN
                     IDEIVVCIKKEEEDFFKENIINKYNFKNIKIAYGGKERQDSIYNGLKKLDENCDIVLI
                     HDGARPFVDHRIINESIKVAKEKKAVVVGVPVSDTIKIVSDGTVQETPERNLLWAAQT
                     PQTFEYNLIIDAYEQAYKNNYYGTDDSMLVENIGQSVTMVMGSYENIKITSPEDLNIA
                     EQILNMEKRDEVNSRRRII"
     gene            3210..3695
                     /locus_tag="KR257_003160"
     CDS             3210..3695
                     /locus_tag="KR257_003160"
                     /EC_number="4.6.1.12"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009887828.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="2-C-methyl-D-erythritol 2,4-cyclodiphosphate
                     synthase"
                     /protein_id="HBH0031831.1"
                     /translation="MRIGLGYDVHKLTEDRKLIIGGVEIPHDKGLLGHSDADVLIHAI
                     MDSILGALALGDIGKHFPDTDEEYKGADSMKLLEHVYNLITSKGYKIGNIDSTIIAQS
                     PKMAPYIESMRSNISKVLNTDIDNINIKATTEEGLGFTGAKQGIASQSICLLLLTSQN
                     N"
     misc_binding    3790..3998
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00230"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="T-box leader; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /bound_moiety="tRNA"
                     /db_xref="RFAM:RF00230"
     gene            4062..5777
                     /locus_tag="KR257_003161"
     CDS             4062..5777
                     /locus_tag="KR257_003161"
                     /EC_number="6.1.1.15"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435583.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="proline--tRNA ligase"
                     /protein_id="HBH0031832.1"
                     /translation="MKMSKMFMPTLKEIPADAEITSHQLMVRSGMIKKMTSGVYNQLP
                     MGLRVFKKIEQIIREELNKKDCQEILCAALLPSELWKESGRWTAMGEEMFRLKDRTER
                     EYCLGPTHEEAFTDIIRQEITSYKQLPLNLYQIQVKYRDERRPRFGVMRTKTFTMKDA
                     YSFDVDDKGLDKSYQDMFDAYVSIFDRCGLENSPVQADSGAIGGSTSAEFMVKSEVGE
                     DEVVFCSGCDYAANVERAESCNLASQKEEMKELEEVHTPGAATIKELEEFLKTSPDKF
                     AKTLVYEADGKTVVVVVRGDREVNEIKVSNAIGSVIEFALATDDVVRKVTNAEVGFAG
                     PIGINADYVFIDKEIVEQRNIVVGANKTEYHIKNANYGRDFEGIVGDFRNVQEGDKCI
                     VCGKPLEIARGVEVGHIFKLGTKYSESMNANFIDKDGKSKPIVMGCYGIGVERTAAAI
                     IEQHNDEKGIIWPLSVAPYHVVIVPANMKNEEQISIAENIYNDLQAMGVEVLLDDRDE
                     RIGVKFNDSELIGIPMRITVGKNINEGKVEFKLRHKEDKEIIDIEEINEKVKAEFIRN
                     NVRLG"
     gene            5899..7344
                     /locus_tag="KR257_003162"
     CDS             5899..7344
                     /locus_tag="KR257_003162"
                     /EC_number="6.1.1.15"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895182.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="proline--tRNA ligase"
                     /protein_id="HBH0031833.1"
                     /translation="MAKNEKQFVEEITKMEDDFPQWYTDVITKTDLVDYAPVKGFMVV
                     KPYGYALWEKMQEFMDKKFKETGHKNCYFPLLIPESLLNKEAEHVEGFAPEVAWVTHG
                     GNKKLEERLCVRPTSETIICTMYAKWLKSYRELPYLYNQWCSVVRWEKSTRPFLRTSE
                     FLWQEGHTLHETAEEAQEETIQQLEVYKALCEELLAMPVVAGQKSESEKFAGGERTYT
                     IEAMMHDGKALQSGTSHFLGQHFTKAFDITFADREGNLANPYHTSWGASTRLIGGLIM
                     THSDNRGLVLPPRVAPIQVVIVPIAAKKGNVMETVDKIYADLKAKGVAVEVDDRDNYT
                     TGWKFNEWEMKGVPVRVEIGPKDIENNQAMVFRRDTLEKDSMPLEGLADAICDLFDVI
                     HNDMFEKARKHREDNTSIVENMDEFRKALEEKPGFIKTMWCGDAECEAKIKEETGATI
                     RCLPFEQENLGHKCVYCGKEADSMVVMAKAY"
     gene            7784..9265
                     /locus_tag="KR257_003163"
     CDS             7784..9265
                     /locus_tag="KR257_003163"
                     /EC_number="6.1.1.17"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892542.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glutamate--tRNA ligase"
                     /protein_id="HBH0031834.1"
                     /translation="MNVRVRFAPSPTGFVHIGSLRTALYNYLFAKKMGGEYILRVEDT
                     DQSRLVEGAIENMLNAMKWAGVNHSEGVILDDSGKVVQKGEYGPYIQSQRLDIYQEYI
                     KQLLDSGKAYYCFCTKERLDEVRDAQRAAGETAKYDGHCKNLSKEEVEANIKAGIPYV
                     IRLRLPENHTIKFTDLVRGDMEFNTNDLDDQVLMKTDGFPTYHFAVVVDDYLMKITHV
                     IRGEEWVSSTPKHVYLYEAFGWEAPVFVHLPNILNKEKKKLSKRQGDVAVEDFKKKGY
                     LPEGLVNYVALVGWSPEDNQELFTMEELEKAFSVERVSKSGGVFDTEKLNWVNQHYIK
                     DGDDAYLTDLAIPFLIEDGFITEEEATNKYDFLKSMISVLKEKLQYVKEVTEHASIFF
                     GDKIEVETEEGREFLRLEHIPTLIDALREKIEKTEVLNAEFVQAMLKEIQKEYKIKGK
                     NLFMGSRIILTGQMHGPDLPKVMEVLGKETCLNRIAYVKNNIL"
     gene            9486..9641
                     /locus_tag="KR257_003164"
     CDS             9486..9641
                     /locus_tag="KR257_003164"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421202.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0031835.1"
                     /translation="MYSNIDDVKKELKELCLEYVTILEKLKDEKMITEETFEKCSSQK
                     KIFLEEQ"
     gene            9786..11183
                     /locus_tag="KR257_003165"
     CDS             9786..11183
                     /locus_tag="KR257_003165"
                     /EC_number="6.1.1.16"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895184.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cysteine--tRNA ligase"
                     /protein_id="HBH0031836.1"
                     /translation="MKVYNTLTRTKEEFVPLEEGKVKMYVCGPTVYNYIHIGNARPFI
                     IFDTLRRYLEYRGYDVTYVQNFTDVDDKIINRSHEEGISPEEVAAKYIKEYFVDCDGL
                     GIKRATVHPQVTDNIQQIIEFIKELEDKGYAYAVNGDVYFDTNKFEGYGKLSGQKQED
                     LEAGARIEVNDQKRHPMDFVLWKAKKEGEPGWDSPWGEGRPGWHIECSVMSKRYLGET
                     IDIHAGGQDLTFPHHENEIAQSEARSGKTFSKYWMHNGYININDEKMSKSKGNFFTVR
                     DISKLYDLEIVRFFMLSAHYRNPVNFSDEMLNQAKAGLERLYNTKEKLEFTLSNLVES
                     PLTEKEVELVKELDDFRQKFIDAMDDDVNTADAVSVIFELAKLINSNVDENSSLEFAK
                     KCLDEFNELTGVLNIVNKKKDTVLDKDIEELIQKRTDAKKNKEFQLADDIRQQLLDMG
                     IVLEDTRQGVKWKRI"
     gene            11168..11581
                     /locus_tag="KR257_003166"
     CDS             11168..11581
                     /locus_tag="KR257_003166"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729256.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Mini-ribonuclease 3"
                     /protein_id="HBH0031837.1"
                     /translation="MEKDIKMEKTELVTMSPLVLAYLGDTVYETYIREYLIRQNTQRK
                     VNDLHKLAIKYVKAKAQATIIHEIEIELTEEESKIYKRGRNQKSNTSPKNADIIDYKH
                     ATGFEALVGYLYLNNEIERLQYIINKGIKIIERDM"
     gene            11687..12445
                     /locus_tag="KR257_003167"
     CDS             11687..12445
                     /locus_tag="KR257_003167"
                     /EC_number="2.1.1.148"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421197.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="FAD-dependent thymidylate synthase"
                     /protein_id="HBH0031838.1"
                     /translation="MKVKLISHTPEPEKVIAMAAKLCYSPVGTDEIEKDLTDESIEKF
                     LNMLLSIGHGSILEHASFTFSIEGISRACSHQIVRHRIASFSQQSQRYVKLEQFEYII
                     PPEIEKIEKAKELFIDSMKKDQENYDKLVEILFENHYNDLIKNGKNEKTAKRQAEKKA
                     IEDARYVFPNACETKMVFTINARSLFNFFEHRCCERAQWEIRNLAVEMLREVKKVAPI
                     LFKKTGPSCVNGSCPEGTMTCGDIVQVREKFKAL"
     gene            12458..13195
                     /gene="rlmB"
                     /locus_tag="KR257_003168"
     CDS             12458..13195
                     /gene="rlmB"
                     /locus_tag="KR257_003168"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009887855.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="23S rRNA
                     (guanosine(2251)-2'-O)-methyltransferase RlmB"
                     /protein_id="HBH0031839.1"
                     /translation="MASIEGRNPVIEAIKSDREIDKILIANSAKEGSIKKIIGMAKDK
                     NIIIQYVDKHKLDEVSTSHSHQGVIAYASEYKYYELDELIDLAKNKDEDPFFIILDEI
                     TDPHNLGSIIRTADAVGAHGVIIPKRRSVHITPVVAKASAGAVEYMPVCKVTNIVNTI
                     KRLKEEGLWIAAADMDGETFYKQNLTGPLGVVIGSEGFGISRLVKQNCDFIVKMPMIG
                     NVTSLNASVAGGILLYEIFRQRLDKSK"
     gene            13198..13725
                     /locus_tag="KR257_003169"
     CDS             13198..13725
                     /locus_tag="KR257_003169"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425496.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NYN domain-containing protein"
                     /protein_id="HBH0031840.1"
                     /translation="MKKNINHYLIIDGYNIINAWDNLKELAKEDLEDSREKLIDDIIE
                     FSEFMGYKTIIVFDAYNVKNSREKVEKRKHITIVYTREHQTADSYIEKFITSLSKYDD
                     VKVATNDYAEQQMILGKGATRMSARELKLELDRSKNKMKEKNIGLRKKIQRNWLEERL
                     DKETLSKLENIRRKR"
     gene            13790..14437
                     /gene="sigH"
                     /locus_tag="KR257_003170"
     CDS             13790..14437
                     /gene="sigH"
                     /locus_tag="KR257_003170"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892548.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RNA polymerase sporulation sigma factor SigH"
                     /protein_id="HBH0031841.1"
                     /translation="MLVAKEKSYELVDNCQQDEYNIVLRASEGDKIALEYIITKYRNF
                     VKAKAKSYFLIGADKEDIIQEGMIGLYKAVRDFDGSKTNSFKCFAEICITRQIITAIK
                     TATRQKHIPLNSYVSLNKPIYDEESDRTLLDIIATSIVTDPEELIISKEELKNIESKM
                     NELLSDLELEVLELYLNGKSYQFIADKLKRDVKSIDNALQRVKRKLEKHLENRND"
     gene            14511..>14851
                     /locus_tag="KR257_003171"
     CDS             14511..>14851
                     /locus_tag="KR257_003171"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009887863.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosome-binding GTPase"
                     /protein_id="HBH0031842.1"
                     /translation="MAKAKYERTKPHVNIGTIGHVDHGKTTLTAAITKTLYDRYQLGE
                     AVDFANIDKAPEERERGITISTAHVEYETPNRHYAHVDCPGHADYVKNMITGAAQMDG
                     AILVCSATDGP"
BASE COUNT         6200 a         1520 c         2805 g         4326 t
ORIGIN      
        1 atcaagtaat cctaaaaaaa ttattattga tagcaaatgt atacatttta cctcatttat
       61 gactacacat aagtatgaaa ttaaagatat agaaaagata agaataagag aattttataa
      121 taaaaaaatt tatgtaaaaa ttaatgatgg aaaccttttt aaaggtaggt attggataag
      181 aacaaatatg tttaataata gtatagcatt atatagctat ttcattgagt tggaagagtg
      241 cttatatcca gattcactaa aatttagaaa taaaaaattt gagaataaga acatataaaa
      301 ataaaaaatt gaattgaagc ctagcttaat cttttttgat aagatataag tttgaacttt
      361 atactaaatt tttagaattt tcaatcaaga caataacata atagctaagc aattagaaca
      421 caattaagat gtataaggca tgtatatgat gaatgggagg atttaattaa tgttattaga
      481 gaaattaaga aaagaagtat tacaagcatc tttagacctt ttaaactata atttagtgac
      541 attaacagga ggaaatgtaa gtgggagaga tgaacaaact ggctatatag caatcacccc
      601 aagtggaatg gattatagaa atcttacacc aagtgatatt gttatagtag atgtagatgg
      661 aaatattata gatggaaaat ggaaagcatc agtggattta tcagaccact tgtatatata
      721 taagcataga gaagacataa atagtataat tcatacacat tctacatact caagttgttt
      781 tgctatttta aatgaaccta tagaatgtgc aagtacaact cttgcaaatg aagtaggggg
      841 ttcagtacca gttgcaaaat tttcaccacc aacatctaaa aagatgggaa aatgtgttat
      901 tgaagcaatt ggtgacaaaa gagcatgtct tttagcaaat catggcgtaa ttgcagttgg
      961 tccatctgta ggacatgctc ttacagccgc tgtaatgtta gaagattcag caaaagtata
     1021 ttacttagca aaatcaattg gcacaccagt gctactgcct gatgaagaaa ttcaaagagc
     1081 gagagatgta ttttttaatg tctatggtca ggataaataa attagataaa attttaaaag
     1141 taatatgaaa atatagatat tcaatgatat taaggagatt tataatgata taataagttt
     1201 aatagttaag aagtaaaata tgaaatgtaa tagtatataa attcatttaa gactaaaaag
     1261 aataagataa aataaaaagg agtctgtatt tctatgtatt acttattaaa caaaagcaca
     1321 aatccttact ttaatttggc attagaagaa tatctatttt taaatgataa atataatgat
     1381 gatattataa tcatatggag aaatgaagaa tccattttta taggtaaaaa tcaaaatcca
     1441 tatcaggaag tatatcatga tgttattgaa aagggagaaa ttcctatttt aagaagaata
     1501 tctggaggag gaactgttta tcatgactta ggtaatatca atatgtcatt catacaaaaa
     1561 gataggcaac ttcatgagat agattttttg gagcatacta agtttatgca aaagatgctt
     1621 tcaaccttag gactagatgt atctataact gaaagaaaag atttattttt aaatgggaaa
     1681 aaaatttcag gctctgcaca gtctataaaa agaaaaaatt ctctttatca tggaactctt
     1741 ctttacgatt cagatttaaa taaattaact aaatatttaa attcaaataa agcaactgaa
     1801 tcaaatgcaa ctaaatctgt ttcaagtaaa gttacaaata ttaagttttt actcgaaaaa
     1861 gatataaatt actttttaga ttattgtgtt gaatatttaa aatctaatat aaagaatata
     1921 aaagaacttg aattggatga agaagatatt aaaagtgtat acaatatagg agaagataaa
     1981 tataaaaaga tagagtggac atatggtaaa acgccgaaat ttcaagtagt gctaccattt
     2041 aataatgaaa gtaaaataaa tatacatgtt aacagatgga aagtatcaaa attttttatt
     2101 tcttatgatg ataatgtaat taatatggac aagttgttag atttgaattt ctttaaagaa
     2161 gaaataaaag agagtatttt agaaaattat ccacattaca tagatttaat caatttaata
     2221 ttttaatata aaacctctaa tttgataaaa ttgtcttata tcaaactaga ggtttttaat
     2281 attcttgcat attaacaacc attacaaaat tgtaaaatta aaaacaacac tattgaaaaa
     2341 tcaatatata ttgtaataaa tatatgtgtt tttcattagc aaatagacat taactattta
     2401 tacaactgaa aatttaatat ataattaatc agatggttaa aataaaaata ttaaaagttt
     2461 taataaatga tggttaaaaa taaaatacga ggtgatacca tgtatagtgt tataattgtt
     2521 gcagcgggaa gcggaaggag aatgaactta gatataaaca aacagttcat aaaattaaga
     2581 gaaaaagaaa ttattgctca tacaattcaa gttttttatg aaaatataaa tatagatgaa
     2641 atagtggtat gtataaaaaa agaagaagaa gattttttta aagaaaatat aataaataag
     2701 tataacttta aaaatataaa aatagcatat ggcggaaaag aaagacagga ctcaatatat
     2761 aatggtttaa aaaaattaga tgaaaattgt gatatagtac ttatccatga tggagcaaga
     2821 ccatttgtcg accatagaat aatcaatgaa tctataaagg tagctaaaga aaaaaaggct
     2881 gtggttgtag gtgttccagt aagtgatact ataaagatag tgtcagatgg aacagtacaa
     2941 gaaactccag aaagaaattt gctgtgggca gcacaaaccc ctcaaacctt tgaatataat
     3001 ctcataatag atgcttatga acaagcatat aagaacaatt attatggtac tgatgattca
     3061 atgttggtag aaaatatagg tcaaagtgtc actatggtaa tgggttctta tgaaaacata
     3121 aaaataacta gtccagaaga tttaaatata gcagaacaaa tattaaatat ggaaaaaaga
     3181 gatgaagtta acagtagaag gagaattata tgagaatagg attaggatat gatgtacaca
     3241 aattaacaga ggatagaaaa cttataatcg gtggtgtaga gataccacac gataaaggtt
     3301 tgttgggtca ttctgatgct gatgtattga tacatgcaat aatggattct attttaggtg
     3361 ctctagcatt aggagatata gggaagcatt tcccagatac agatgaagaa tataagggag
     3421 cagatagtat gaaattatta gaacatgtgt ataatctaat aacaagtaaa ggatataaaa
     3481 ttggtaatat agacagtact ataattgctc aaagccctaa gatggctcca tatattgaga
     3541 gtatgagaag taatatatca aaagttttaa acacagacat tgataatata aacataaagg
     3601 caacaacaga agaaggtctt ggttttacag gagcaaaaca gggaatagct tcacaaagta
     3661 tttgtttatt attgttgaca agtcagaata attaatatat tattagtaat aagtttaatg
     3721 gatatcaagt aataggccta tatagaatat ctataatgta tgaatttaag tgaaattaat
     3781 ataaatataa aattagctat gataaagaaa tagtaaaatg atgaaatctt cacagagaga
     3841 aaacggtggt gagagttttc aagaggaagt ctttgaacct gtcttttagc ttaaaggtat
     3901 aaaaatcttt acggtaggaa ccgttatatt cccaaaagag agctattcat atagctaact
     3961 agagtggtac cgcggaaatt aaacctttcg tctctatact tgtatagaga tgagaggttt
     4021 tttatatttt caggaagtta atattcagga ggaatctatt aatgaaaatg tcaaaaatgt
     4081 ttatgccgac attaaaagaa atcccagcag atgctgagat tacaagccat caattaatgg
     4141 ttaggtcagg catgataaaa aaaatgactt caggtgttta taaccaatta ccaatggggt
     4201 taagagtgtt caaaaaaatt gaacaaataa ttagagaaga attaaataaa aaagattgtc
     4261 aagaaatact ttgtgcagcc ttacttcctt ctgaattatg gaaagagtct ggaaggtgga
     4321 ctgctatggg tgaagaaatg tttagactaa aagacagaac agaaagagag tactgtcttg
     4381 ggccaacaca tgaagaagca ttcactgata taataagaca agaaattact tcatataaac
     4441 aattgccact aaacttgtac caaatacaag taaaatatag agacgagaga agaccaagat
     4501 ttggtgttat gagaactaag acttttacaa tgaaggatgc atatagtttt gatgtagatg
     4561 ataaaggttt agataagtca tatcaagata tgtttgatgc atatgtaagt atatttgata
     4621 gatgtggatt ggagaatagc cctgtacagg cagattcagg agctatagga ggttctacat
     4681 cagccgaatt tatggttaag tcagaagttg gtgaagatga agttgtattt tgtagtggat
     4741 gtgattatgc agccaatgta gaaagagcag aatcttgtaa tctagcatca caaaaagaag
     4801 aaatgaaaga attagaagag gttcatacac caggagcagc tacaataaaa gagttagaag
     4861 aatttttaaa aacttctcca gataagtttg ctaaaacttt agtatatgag gcagatggaa
     4921 aaacagttgt agtcgttgta agaggagata gagaagttaa tgaaatcaaa gtatctaatg
     4981 ccataggttc tgttatagaa tttgctcttg ctacagatga tgtagtgaga aaagtaacta
     5041 atgcagaagt aggatttgca ggtccaatag gtataaatgc tgactatgta tttatagata
     5101 aagaaattgt tgaacaaaga aacatagttg ttggggctaa taaaactgag taccatataa
     5161 aaaatgctaa ctatggaaga gattttgaag gaatagttgg agattttaga aatgttcaag
     5221 aaggcgacaa gtgtatagta tgtggtaagc cacttgaaat agctagaggt gttgaagtag
     5281 gacatatatt taaactagga actaagtact cagaatctat gaatgcaaac ttcatagaca
     5341 aagatggaaa atcaaagcct atagtaatgg gatgttatgg aataggtgtt gaaagaacag
     5401 cagcagctat aattgaacaa cataatgatg agaaaggtat aatatggcct ttgtcagtag
     5461 ctccatacca tgttgtgata gttccagcaa atatgaaaaa tgaagaacaa atatcaatag
     5521 ctgaaaatat atataatgat ttgcaagcta tgggtgtaga agttttatta gatgacagag
     5581 atgaaagaat aggtgtcaaa ttcaatgatt cagaattaat aggaatacct atgaggatta
     5641 cagtaggtaa aaatattaat gaaggtaaag tagaatttaa acttagacat aaagaagata
     5701 aagagataat tgacatagaa gaaataaatg aaaaagtaaa ggcagagttt atcaggaata
     5761 atgttaggtt aggataataa cttaaataag atattgtata gataatcaaa gttgtacttt
     5821 atagacacca ttttatctat atataaggat ataaaatggt gtttttttat aaaacaaata
     5881 aatgaggagg taattaaaat ggcaaaaaat gaaaaacaat ttgttgaaga aataacaaag
     5941 atggaagatg attttccaca atggtacaca gatgtaataa ctaagactga cttagttgat
     6001 tatgcaccag taaaaggttt tatggttgta aagccatatg gatatgcatt atgggaaaag
     6061 atgcaagaat ttatggataa aaaatttaaa gaaactggac ataaaaactg ttattttcca
     6121 ttattaatac cagagagttt attaaacaaa gaagcagaac acgttgaagg ttttgctcca
     6181 gaagttgcat gggtaacaca tggaggaaat aaaaaattag aagaaagatt atgtgtaaga
     6241 cctacttcag agactataat atgtacaatg tatgcgaaat ggttaaaatc atatagagaa
     6301 ttaccatatc tttataatca atggtgctca gttgttagat gggaaaaatc aactagacct
     6361 ttcttaagaa catctgagtt tttatggcaa gaaggtcata cgttacatga aacagcagaa
     6421 gaagcacaag aagaaacaat acaacaatta gaagtatata aagcgctatg tgaagaatta
     6481 cttgcaatgc cagttgtagc tggtcaaaaa agtgaaagtg aaaaatttgc aggtggtgaa
     6541 agaacatata ctatagaagc tatgatgcat gatggtaaag cattacaatc aggtacaagt
     6601 cacttcctag gtcaacactt tactaaggct tttgatatta cttttgcaga tagagaagga
     6661 aatttagcta atccatatca tacatcttgg ggagcatcta caagacttat aggtggactt
     6721 ataatgactc atagtgataa cagaggttta gtattaccac caagagtagc tccaattcaa
     6781 gttgttatag ttcctatagc tgctaaaaaa ggaaatgtaa tggagactgt tgataaaata
     6841 tatgctgatt taaaagctaa gggagtagct gtagaagttg atgatagaga taactataca
     6901 actggatgga aatttaatga gtgggaaatg aaaggtgttc cagtaagagt tgaaattgga
     6961 ccaaaagata tagaaaataa tcaagctatg gtatttagaa gagatacttt agaaaaggat
     7021 tctatgcctt tagaaggatt agctgatgct atatgtgatt tatttgatgt tatacacaat
     7081 gatatgtttg aaaaagcaag aaaacataga gaagacaata catctatagt tgaaaatatg
     7141 gatgagttta gaaaagcttt agaagaaaag ccaggattca taaagactat gtggtgtgga
     7201 gatgcagaat gtgaagctaa gattaaggaa gaaacaggag caactataag atgcttacct
     7261 tttgaacaag aaaacttagg tcacaagtgt gtgtactgtg gaaaagaagc agatagtatg
     7321 gtagtaatgg caaaagctta ctaaaataca tttaaataaa aactggggta gaaagtattt
     7381 aatactttat cccagttttt ttgtttttta tgagtaataa aatgtatttg taactatgtc
     7441 ataagataag tcatagatac ttatattaaa aagaatataa tagagaacta tttttaataa
     7501 ttacatatta atgaaagcaa aatatttttg ttatatagat tttcaataaa gcaaacaata
     7561 aatataaatg aatattagta aggagtgctt ttaattttta gaaaataaat gacttaaaag
     7621 aaagatttat gaaattaaaa ctaggatttt ctgatataat aaacatgtgt atttttaaat
     7681 aaaaaggata ttattattag atttgattaa aaataaactt gcaaaacaat gtactagttt
     7741 aatattatag ttatattgaa taaaatatca ggaggaagta aaaatgaatg taagagtaag
     7801 gtttgcacca agtccaacag gatttgtaca tataggtagt ttgagaactg ctttatataa
     7861 ctatttattt gcaaaaaaaa tgggcggaga atatatatta agagtggaag atacagacca
     7921 aagtagatta gtagaaggtg ctatagagaa tatgcttaat gctatgaaat gggctggggt
     7981 caaccatagt gaaggtgtta tattagatga tagtggaaaa gtagtacaaa aaggagaata
     8041 tggtccatat attcaatctc aaagattaga tatataccaa gaatatataa agcaactttt
     8101 agatagtgga aaagcttatt actgtttctg tacaaaagaa agactggatg aagtaagaga
     8161 tgctcaaaga gcagcaggag aaacagctaa atatgatggt cattgtaaga atctttctaa
     8221 agaagaagta gaagcgaata taaaagcagg aataccatat gttataagat taagattgcc
     8281 agagaatcat acaattaagt ttacagactt agttagagga gatatggaat ttaatactaa
     8341 tgacttagat gaccaagtat taatgaaaac agatggattt ccaacttatc attttgcagt
     8401 agttgttgat gactatttga tgaaaattac acatgttata agaggagaag aatgggtatc
     8461 atctactcca aaacatgttt atttatatga agcttttgga tgggaagcac ctgtatttgt
     8521 gcatttacca aatatactta ataaagaaaa gaaaaaatta agtaaaagac aaggtgatgt
     8581 agctgttgaa gactttaaga aaaaaggata tttaccagag ggattagtaa actatgtagc
     8641 attagttggt tggtctcctg aagataatca agaattgttt acaatggagg aattagaaaa
     8701 agccttctct gtagaaagag tctctaaaag tggtggagta tttgatactg aaaaattaaa
     8761 ttgggttaat cagcattata taaaagatgg tgatgatgct tatctaacag acttagcaat
     8821 accattttta atagaagatg gatttataac agaagaagaa gctactaata aatatgattt
     8881 cttaaagagt atgatatcag tacttaaaga gaaattacaa tatgtaaaag aagttactga
     8941 acatgcaagt atattttttg gagataaaat agaggtagaa actgaagagg gaagagagtt
     9001 cttaagatta gaacatatac ctactttaat agatgctttg agagaaaaaa tagaaaaaac
     9061 agaggtatta aatgctgagt ttgttcaagc tatgcttaaa gaaatacaaa aagagtacaa
     9121 aataaaaggg aaaaatttat ttatgggctc aagaataatt ttgacagggc aaatgcatgg
     9181 tccagattta ccaaaagtaa tggaagtttt aggaaaagaa acttgcttaa atagaatagc
     9241 ttatgtaaaa aataatatat tatagtcata aaagtccgct aatttagaag cggacttttt
     9301 ttgtgttagt atttggtgaa aatatctgct taagaaaatg aaggtattta aggtaataaa
     9361 tttaatatat aaaaagcaaa gcaaaaatat aaataaaata tgaataataa actaataaaa
     9421 tattaagcat agaagaaggg aatctattat tttagtttga tttaattatt aagggggtaa
     9481 ttactatgta tagtaatatt gatgatgtta aaaaggaatt aaaggagcta tgcttagaat
     9541 atgttacaat tttagaaaaa ttaaaagatg aaaaaatgat tacagaagaa acttttgaaa
     9601 agtgctcttc tcaaaaaaaa atatttttag aagaacaata gaggatggta atagtattat
     9661 tattatgtag tttgaaagat agtacgaaaa atgatagtaa tactattatt tattgcaatt
     9721 ttcaactata atataatata taatgttaag aagataattt ataaaaatac agtgaggtga
     9781 tgagtgtgaa agtttataat acattgacta gaacaaaaga agaatttgtt ccattagaag
     9841 aaggaaaggt aaaaatgtat gtgtgtggtc caacagttta taactatata cacataggta
     9901 atgcaagacc atttataata tttgatactc taagaaggta tttagagtat agaggatatg
     9961 atgtaactta tgtacaaaac tttacagatg ttgatgataa gattataaat agaagtcatg
    10021 aggagggaat atctcctgaa gaagttgcgg ctaagtatat aaaagaatat tttgtagact
    10081 gtgatgggct aggaataaaa agagctactg ttcatcctca ggttacagat aatatacaac
    10141 agattataga gtttataaaa gagttggaag ataagggata tgcatatgca gtaaatggtg
    10201 atgtatattt tgatacaaat aagtttgaag gttatggaaa actttcaggt caaaaacaag
    10261 aagatttaga ggcaggggct agaattgagg ttaatgacca aaaaagacat cctatggact
    10321 ttgttctttg gaaggcaaaa aaagaaggtg agccaggatg ggatagccct tggggagaag
    10381 gtagaccagg atggcatata gaatgttctg ttatgtctaa gagatattta ggtgaaacaa
    10441 ttgatataca tgcaggtggg caagatttaa cattcccaca tcatgaaaat gaaatagctc
    10501 aaagtgaagc tagaagtgga aaaacattct caaaatactg gatgcataat ggatatataa
    10561 atataaatga tgaaaagatg agtaaatcaa aaggtaattt ctttacagta agagatatat
    10621 caaaattata tgatttagag atagtaagat ttttcatgtt atcagcacat tatagaaatc
    10681 cagtaaactt tagtgatgag atgttaaatc aagctaaagc aggtcttgaa agactatata
    10741 atactaaaga aaaattagaa tttacgctaa gtaatttagt agaatctcct ttaacagaaa
    10801 aagaagtaga gcttgttaaa gaattagatg actttagaca aaaattcata gatgctatgg
    10861 atgatgatgt taatacagca gacgcagtaa gtgtaatatt tgaattagct aagttaataa
    10921 attctaatgt agatgaaaat tcttctttgg agtttgctaa aaaatgctta gatgaattta
    10981 atgaacttac aggagtatta aatattgtaa ataagaaaaa agatactgta ttagataaag
    11041 acattgaaga attgatacaa aaaagaactg atgcaaagaa aaataaagag tttcaattag
    11101 ctgatgatat tagacaacaa ttactagata tgggaattgt attagaagac acaagacaag
    11161 gtgttaagtg gaaaaggata taaaaatgga aaaaactgaa ttagttacta tgtcaccatt
    11221 agttttagca tacttaggtg atacagtgta tgagacatat ataagagaat atttaattag
    11281 acagaataca caaagaaaag ttaatgattt gcataaacta gctataaagt atgtaaaagc
    11341 taaagctcag gcaactataa ttcatgaaat tgaaattgag ttaactgaag aagagagtaa
    11401 aatttataaa aggggaagaa atcaaaagtc aaatacttct cctaagaatg cagatattat
    11461 agactacaaa catgcaactg ggtttgaggc attagtggga tatttgtatt taaataatga
    11521 aatagagaga cttcaatata ttatcaataa aggaatcaaa attattgaaa gagatatgta
    11581 aatattaaag agtgttgtct taataataag taataaggca acactttttt tataactaat
    11641 gtataataaa tatatagaaa ttagtaatga gaaaggataa aaagttatga aagtaaaatt
    11701 aatatcacat acacctgaac cagaaaaagt aatagctatg gcagctaagc tatgttattc
    11761 accagttggg acagacgaaa tagaaaaaga cttaacagat gaaagtatag agaaattttt
    11821 aaatatgtta ttaagtatag gtcatgggtc aatattagaa catgcttcat ttacattttc
    11881 aatagaaggt atttcaaggg cttgttcaca tcaaattgtt agacatcgta tagctagttt
    11941 ttcacaacaa agtcaaagat atgttaaatt agaacaattt gagtacataa ttcctccaga
    12001 aatagaaaaa atagaaaagg caaaagagtt atttatagac tccatgaaaa aagaccaaga
    12061 gaattatgat aagttagttg aaatattgtt tgaaaatcat tataatgacc taataaaaaa
    12121 cggtaaaaat gagaaaacag ctaaaagaca agctgaaaag aaagcaatag aagatgctag
    12181 atacgtattt ccaaatgcat gtgaaacaaa aatggtattt actataaatg ctagaagttt
    12241 gtttaatttc tttgaacata gatgctgtga aagagcacag tgggaaataa gaaatttagc
    12301 tgtggagatg ttaagagagg ttaaaaaggt tgctcctata ttatttaaaa agaccggtcc
    12361 aagttgtgta aatggaagtt gtccagaagg aactatgact tgtggagata tagttcaagt
    12421 tagagaaaaa tttaaggcct tgtaggaggt gaataatttg gcgagtatag aaggaagaaa
    12481 tccggtaata gaagcaataa aaagcgacag agaaatagat aaaatattaa ttgcaaattc
    12541 agctaaagaa ggttcaatta agaaaataat aggaatggct aaagataaga atataattat
    12601 tcagtatgtt gataaacata agctagatga agtaagtaca agtcattcac atcaaggtgt
    12661 aatagcttat gcaagtgagt ataagtatta tgaattagat gagctaatag atttagcaaa
    12721 gaataaagat gaagacccat ttttcattat attagatgag ataacagacc cacataattt
    12781 gggttcaata ataaggacag cagatgcagt aggagcacat ggagttatca ttccaaaaag
    12841 aaggtctgta cacataactc ctgtagttgc caaagcatct gctggagcag tagaatatat
    12901 gccagtttgc aaggtaacca atatagttaa tacaataaaa agactcaaag aagaagggct
    12961 gtggattgct gcagctgata tggatggaga aactttttat aaacaaaatc ttactggtcc
    13021 tcttggtgta gtaattggaa gtgaaggttt tggaatatct agattggtta aacaaaactg
    13081 tgactttata gtaaaaatgc caatgatagg taatgttaca tctttaaatg catctgtagc
    13141 aggtggaata cttttatatg agatattcag acaaagactg gataaaagta aataggcatg
    13201 aaaaaaaata taaatcatta cttaataata gatggctaca atattataaa tgcgtgggac
    13261 aatttgaaag aactggctaa agaggactta gaagattctc gagaaaagct tattgatgac
    13321 attatagaat tttctgagtt tatgggttat aagactataa tagtttttga tgcttataat
    13381 gttaaaaatt ctcgagaaaa agttgaaaaa agaaaacaca taacaatagt ttatacaaga
    13441 gaacaccaaa cagcagatag ttatatagag aaatttataa cttctttatc aaagtatgat
    13501 gatgtaaaag tagccactaa tgactatgca gaacagcaaa tgattttagg aaaaggtgct
    13561 actagaatgt ctgcaagaga attaaagtta gagttagatc gttccaagaa taaaatgaag
    13621 gaaaaaaata tcggtttgag gaaaaaaatt cagcgaaatt ggttggagga aaggttagat
    13681 aaagaaacat tgtcgaaact tgagaacatt cgtagaaagc gttgaaatta ctaggttctt
    13741 tagactataa tatacctata aatttgtttt atatatgggg gagatttaca tgttggtagc
    13801 aaaagaaaaa agttatgagt tagtggacaa ttgtcagcag gatgagtata acattgtatt
    13861 aagagcaagt gaaggggata aaatagcact agagtacatt attactaaat acagaaattt
    13921 tgtaaaggca aaagcaaagt catatttttt aattggagca gataaagaag atataataca
    13981 agaaggaatg ataggccttt ataaggcagt tagagatttt gatggaagta agaccaattc
    14041 atttaaatgt tttgcggaga tatgtataac aagacaaata ataactgcta taaaaactgc
    14101 aacaagacaa aaacatatac ctttaaattc atatgtttct ttgaataaac caatatatga
    14161 tgaagagtca gacagaacac ttttagatat tatagctaca agtatagtaa cagatccaga
    14221 agagcttata attagtaaag aagagttaaa aaatatagaa tcaaaaatga acgaattgtt
    14281 aagtgacttg gaattagaag tactagaatt atatttaaat ggaaagtcat accagtttat
    14341 agcggacaag cttaaaagag atgtaaagtc aatagataac gctttacaaa gggttaagag
    14401 aaaattagaa aaacatcttg aaaacagaaa tgattaatag taaaatactt accataagct
    14461 tattgtgagc aaaattaatt tatatcgaaa gataagggag gaaattcaaa atggctaaag
    14521 ctaaatacga aagaacaaaa cctcatgtta atatagggac aataggacac gtagaccacg
    14581 gtaaaactac attaacagca gcaataacaa aaacattata tgacagatat caattaggag
    14641 aagcagtaga tttcgcaaac atagataaag ctccagaaga aagagaaaga ggaatcacaa
    14701 tatcaacagc acacgttgag tatgaaacac caaatagaca ctatgcacac gttgactgcc
    14761 caggacatgc tgactacgtt aagaacatga taacaggagc agcacaaatg gatggagcaa
    14821 tattagtttg ttcagcaaca gatggaccaa t
//
LOCUS       DAEPID010000089        14575 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.089, whole genome shotgun sequence.
ACCESSION   DAEPID010000089 DAEPID010000000
VERSION     DAEPID010000089.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 14575)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 14575)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..14575
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.089"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            358..1266
                     /gene="trxB"
                     /locus_tag="KR257_003172"
     CDS             358..1266
                     /gene="trxB"
                     /locus_tag="KR257_003172"
                     /EC_number="1.8.1.9"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430620.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="thioredoxin-disulfide reductase"
                     /protein_id="HBH0031843.1"
                     /translation="MVDIIVIGAGPAGLTSAIYAMRAGLSVTVFEKNIYGGQVASTSE
                     VENYPAVQKISGVEFSNNIYNQAVAQGVDIQFDEVEEINLEGKVKVVKTSSGEHKAKA
                     VILANGVERRKLGCAGEQEFTGRGVSYCATCDGAFFKDKEVAIVGGGNTALEDALFLA
                     NNCTKVYLIHRRDSFRGEEVLEKSVKARENIEILYSHGVEKIEGEKTVSKIEVKNLKT
                     EEKRTIDVSGIFIAIGLKPNNKMFENVLDLDEGGYIISDESCTTSVEGVYVAGDSRTK
                     FLRQIITAASDGAIAAVQAANYINVE"
     gene            complement(1356..3179)
                     /gene="typA"
                     /locus_tag="KR257_003173"
     CDS             complement(1356..3179)
                     /gene="typA"
                     /locus_tag="KR257_003173"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424463.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="translational GTPase TypA"
                     /protein_id="HBH0031844.1"
                     /translation="MSQKHKIINIAVIAHVDAGKSTLVDAFLSQSGVFRKNEVVKDCV
                     MDSNDLEKERGITIYSKNCAINYEDYKINIVDTPGHSDFSSEVERVMKTVDTVILLVD
                     ASEGPMPQTRFVLQKSLEFGLKPILFINKIDKKDQRAEEVVNEVFDLFVDLNATDEQC
                     EFPIIYGIAKQGIAKLEMDDDSEDLSPLFKTIVNHVEAYPNYDNEPLQFQISALAYDD
                     YVGRLGIGRIYKGTLKNNTQVAICREDSVVSKGKVSKLSVYEGLKQVEVDEATSGEIV
                     VIAGIPDISIGETICDLDSPLPMEMIKIEEPTLSMNFLVNDSPFVGKSGKFVTTRHLK
                     DRLEKELEVNVGLKVEPLDTTDGYKVSGRGELHLSILLENMRREGYEVGVSKPEVLMH
                     KEDGKLMEPIERVVVNCPEVYSGTIINELNMRKGMMESMSIEGDYVKIEFLAPTRGLL
                     GYRSEFINATRGEGTLVRSFEKFEEFKGEIPSRGNGVLIAQGPGVTMGYSLNALSDRA
                     VMFVDPGVEVYEGMIIGMNSRKDDMVVNPCKNKKMSNVRASGSDDAIKLSPPRIFTLE
                     EALEFIEDDELVEITPDSIRLRKRFLNEHDRLRYNKSRQGK"
     gene            3391..3633
                     /locus_tag="KR257_003174"
     CDS             3391..3633
                     /locus_tag="KR257_003174"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424461.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0031845.1"
                     /translation="MLEVTKIIIKYFASESDTFVKEEVCNFEELLKWSHKFIEGKKIE
                     DVLYIKSKENYKVNVIKSLEIKELEIVRKQQIPPYM"
     gene            3781..3972
                     /locus_tag="KR257_003175"
     CDS             3781..3972
                     /locus_tag="KR257_003175"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424459.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1450 domain-containing protein"
                     /protein_id="HBH0031846.1"
                     /translation="MIRVCPNCSNVDVNKLKTLVGEENVKTGCIGQCRAFKKEAVGII
                     DNELEIKETEAEFFEACKE"
     gene            4263..6764
                     /locus_tag="KR257_003176"
     CDS             4263..6764
                     /locus_tag="KR257_003176"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434034.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="copper-translocating P-type ATPase"
                     /protein_id="HBH0031847.1"
                     /translation="MSSNKVVESYKITGMTCAACAKAVERVTKKMDGVYDQNVNIATE
                     KLKIEYDNSKVNFDDIKQVVEKAGYGIIKEESNKKIDMKIDGMTCAACAKAVERVVKK
                     LDGVESISVNIATDKANIDYDPSKVKLSQIKAAIEKAGYKPIEEVRNKVDVDEDKLRK
                     EREMKSLFVKFIVAIVFAVPLFYIAMGPMIIKPIGPWPLPEIINPMTNTFNYALIQLI
                     LVIPVMIAGYKFYINGFKSLFSLSPNMDSLVAIGTLAAFLYSLYTTLQIANGQIQGMH
                     HHQLYYESAGIIIALILLGKYLESKSKGKTSEAIKKLMGLQPKTAIVLVDGKEVETPI
                     EEVEIGDILLVKPGTKIPVDGVVIEGYTSVDESMLTGESIPVEKNVGSKVTGASINKN
                     GVIKFKAEKIGGDTALAQIIKLVEDAQGTKAPIAKLADTVSGYFVPIVIAIAVVASLL
                     WFLIGGKDIVFVLTIFISVLVIACPCALGLATPTAIMVGTGKGAENGILIKGGEALES
                     AHKVNTVIFDKTGTITEGKPKVTDIVLNNNVKEEYLIKIASSAEKGSEHPLGEAIVKY
                     GEEKNIKFEKVDNFKAIPGAGIQVTINDESILLGNRKLMNDNNIKLGDLEEKSNILAS
                     QGKTPMYIAVDGNLSGIIAVADVVKESSKKAIEILHDMGIKVAMVTGDNAKTANAIAN
                     QVGIDMVLAEVLPEDKSKEVEKLQNQGKFVAMVGDGINDAPALAKADIGIAIGSGTDV
                     AIESADIVLMKSDLIDVPTAIKLSHETIKNIKQNLFWAFGYNTIGIPVAAGILYVFGG
                     PLLNPMIAAAAMSLSSVSVVSNALRLKNFKAYKRD"
     gene            6924..7592
                     /locus_tag="KR257_003177"
     CDS             6924..7592
                     /locus_tag="KR257_003177"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424455.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HBH0031848.1"
                     /translation="MNSSILVIEDDSNIQELISEFLSAEGYQVDTANDGLEGIQKFKQ
                     GSYDLVILDIMMPNLDGYGVCKMIRKSSSVPIIFLTALNDEGDQLKGFDLECDDYITK
                     PFSFNLLIKRVEAILRRSNKTINDKFIVFEKLKLDLNTYIAEIDGEPIELTLKEFNIL
                     KALIEKYPQVITREGLLDSIWGYDYYGDTRIVDAHIKNIRKKISLPYIKTVKGIGYTL
                     EKDI"
     gene            7576..8853
                     /locus_tag="KR257_003178"
     CDS             7576..8853
                     /locus_tag="KR257_003178"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424453.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="two-component sensor histidine kinase"
                     /protein_id="HBH0031849.1"
                     /translation="MRRIFDKWEKLSIKYKLFSITTSLLIALALIIYLILYFLLPSYY
                     HEYKIESLQESLKSLVDSSIHFDTYTLEERLYYMAKDQNLAILLKDNQGKIVYGKNEV
                     VILRYSKYMINSLEDEYRTSIPIYTKDAKDGPYTLELVMPLQPIDEANEVIRKLMPYI
                     ISIAILIAIIGAYIYSIVITKPLINIIESEREQEYRRKDFVATISHELKTPITIISGQ
                     IEGMIYSVGKYKDRDTYLKKSYECTQELKDLVNEMIEVSKSEILEKDLKLVSINISEL
                     LNRLVKRQVFLIEEKHMKTILKIEENLEIKADQERITKAINNIINNAIKYSPEESELI
                     IRLYDKNKRISKKTSNQRVVLEIENTGVTIEKRYLEEIFNPFYRIEKSRSRKTGGSGL
                     GLYIVSQIFKSHGFDYSIKNKENSVVFTVEFKN"
     gene            9254..9475
                     /locus_tag="KR257_003179"
     CDS             9254..9475
                     /locus_tag="KR257_003179"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890241.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0031850.1"
                     /translation="MDRLKRDMKNMKEDLKEGVKKTAYVMKNTAEDLKDDAQGAMVNL
                     EMKKDEMMERYEQKKFSKELEKQMKNEMK"
     gene            complement(9764..10528)
                     /locus_tag="KR257_003180"
     CDS             complement(9764..10528)
                     /locus_tag="KR257_003180"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434038.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DeoR/GlpR transcriptional regulator"
                     /protein_id="HBH0031851.1"
                     /translation="MFAEERIQAILNILKKEGRVTVKELSSKFNVTEDCIRKDLKNIE
                     KISSIRRIYGGAVLARETLENQDTKDRKEINIPTKKIIAEKAFNLIEDRETIFLDIST
                     INILLAKLLAESNKKVTLVTNMLDILNVVTSKPNNLNIISTGGLLNLSLDGFVGTPTI
                     EFISKYKFDKTFMGSCGVDVFNSSLTTFEIEDGLTKKAIINSSKKVFIVMEDKKFKFD
                     GNFKFAHLEDISSIITEKTPTPDIVDILSEFNVNVL"
     gene            10802..11476
                     /gene="fsa"
                     /locus_tag="KR257_003181"
     CDS             10802..11476
                     /gene="fsa"
                     /locus_tag="KR257_003181"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424449.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="fructose-6-phosphate aldolase"
                     /protein_id="HBH0031852.1"
                     /translation="MQLILDTGNVEEIKELCTCLPIDGVTTNPSIVSKEKKNFKQLIN
                     EIGEIIGEDMPIHAQVLSTKYEEILEEALYISSLRKNIYVKIPVTQDGLRAIKDLHRK
                     GVKITATAIFTAHQGFLAAKAGANYIAPYVNRLDNISGDGVAMVSELIKIIDTYKMDT
                     KVLAASFKNAQQVIELMQHGVHSVTVPYDICKSMMNHPLTDWSVDKFIEDWENTFGKG
                     SKTNNI"
     gene            complement(11598..12992)
                     /locus_tag="KR257_003182"
     CDS             complement(11598..12992)
                     /locus_tag="KR257_003182"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009905757.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SLC13 family permease"
                     /protein_id="HBH0031853.1"
                     /translation="MGIILKPKQFYMTVIATIILYFSLNYSFNIKFSICLSFLTILIW
                     AVDSVEKTFVALFFVILAFIFNIAPIKVILQFLFTENFYIIILAYIITNAVTKTGVAK
                     IISEKLILNTVNTPKKMILLSYILGILLIFFIPQPFPRVILVSAFYKEFLKEQQITED
                     SKSILLFSIFTASTFTSMFFVNGDTLLNYVVLELGNCNINWGQWAFYMSVPTIITCFI
                     TYFLFTFVFKKELHSIKFISNENLEGNKLHFSYSNLKKEFNLLNKEQKHVFLCLGIMF
                     FMFLTQFIHNINTLIIMSICVLLLLLRKIVGFSTLKEINWKVLIFFIAAFSIGGVLKY
                     SGVVDIMGNYLIKFIPNSSEIISILFLITLTIILNICLGSAVTTSSVVIPLLGSLHIL
                     KENSVTLCLFVYIIVSIQYILPFHHATIMVGHGENLYNSKVIFKYGLTLIPLTYFIII
                     CITFPWWKFIGLEI"
     gene            complement(13070..14416)
                     /locus_tag="KR257_003183"
     CDS             complement(13070..14416)
                     /locus_tag="KR257_003183"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430628.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MATE family efflux transporter"
                     /protein_id="HBH0031854.1"
                     /translation="MKDLTTGHEGKSIFFFAMPMLIGSLFQQLYNTADSIIVGRFIGK
                     EAMAAVSGANPIMFLLVAALMGVSLGFSILVSQFYGSGDLKKVKATIDTTYILLFIGS
                     ILISILGIVFGGPMLKLMNTPESVFAQSKLYLTIIFSGILFSAGYNSVSAILRGLGDS
                     VTPLYFLIIATILNIVLDLTFIVVLRMGVEGVALATIMAQAVSFIISIIYLNKKHEVL
                     KFKIKGIVYDNKIFKDGLRLGLPSGVQQMLFSIGNMALQFLVNSYGTSAMAAFGAGLR
                     IENFISLPIMNLGSAVSTFVAQNIGAGENERVKKGIRESIKMTLVLAVTVIALILLFR
                     ENLIALFNTDKDVIKIGSSYLFIIGPFFLFIGTSFVLSSAMKGAGDSMFALISSIVSL
                     WLGRLPASYMLSKFFGTDGIWMGIPFGWTLGLIVTVIYYKKGHWKTKAIVNHRINE"
BASE COUNT         5762 a         1775 c         2273 g         4765 t
ORIGIN      
        1 atttcacata ataatagtat actgtaaaca aaaggaggta ttaaatatgg gaatagtact
       61 tataacagca gcattagttt tggttatgta tggactttca attctatcat atatatcaga
      121 aagcaatata ttagaagaca ctgtaaatga taaccaataa ggttttgaat tatataaata
      181 agtgagaact gtaaataaaa gttaattttt atttgcagtt tttttatata tatgtaaaat
      241 aaagttaatt aataaaaaat aatgttttgt ttatagtata tatggataat aatagtaaag
      301 tataagaatg atgagaataa tatataagaa ataataatat aaagagaggt aaacgttatg
      361 gtagatatca ttgtaattgg tgctggacca gcaggtttaa cttcagcaat ttatgctatg
      421 agagcagggt taagcgttac agtatttgaa aaaaatattt atggaggtca agttgcaagt
      481 acctctgagg tagaaaatta tccagcagtt caaaagattt ctggggtaga attttctaat
      541 aatatataca atcaagcagt tgctcaaggt gttgatattc agtttgatga ggttgaagag
      601 ataaatttag agggaaaagt aaaggttgta aaaacttctt caggtgaaca taaagcaaag
      661 gctgttattc ttgcaaatgg agttgaaaga cgtaaattag gttgtgcagg ggaacaagaa
      721 tttacaggta gaggagtatc ttactgtgca acatgtgatg gagccttttt taaagataaa
      781 gaagttgcta tagtaggtgg aggaaatact gcactagaag atgctttatt tttagctaat
      841 aattgtacaa aagtgtattt aattcacaga agagatagtt ttagaggtga agaagtgttg
      901 gagaaatctg tgaaagcaag agagaatatt gagatacttt acagtcatgg tgtagaaaaa
      961 atagaaggag aaaagactgt atcgaaaata gaagtaaaaa acttaaagac tgaagaaaaa
     1021 agaactatag atgttagtgg tatttttatt gctataggtc ttaaacctaa taataaaatg
     1081 tttgaaaatg ttcttgattt ggatgaaggt ggatatataa tttcagatga gtcttgtaca
     1141 acatcagtag aaggtgtata tgtagcagga gatagtagaa ctaagttttt acgtcaaata
     1201 ataacagcag catcagatgg agctattgca gccgttcaag cagctaatta tataaatgtt
     1261 gaataatata aatttcaaat aaaaatagcc atataaactg aaataatttt tcagtactat
     1321 atggctattt tgttaattag aggtaaatgt acgttttatt taccttgtct agatttgtta
     1381 tatcttaatc tatcatgttc atttaagaat ctttttctaa gtcttataga atcaggtgta
     1441 atttcaacta attcatcatc ttctataaac tctagagctt cttcaagagt aaatattcta
     1501 ggaggagata attttatagc atcatctgaa ccagaagcac gtacgttact cattttcttg
     1561 tttttacaag gattgactac catatcatct tttctggaat tcataccaat tatcatacct
     1621 tcgtaaactt ctacaccagg gtctacaaac attacagctc tatcacttaa ggcattaaga
     1681 gaatacccca tagtaacacc aggtccttgt gctattaaaa caccatttcc tcttgaaggt
     1741 atttctcctt taaattcttc aaatttttca aatgaacgaa ctaaagtacc ttctccacga
     1801 gtagcgttta taaattcact tcgatatcct aaaagaccac gagtaggtgc taagaactct
     1861 atttttacat agtctccttc tattgacata gactccatca taccttttct catgtttaat
     1921 tcatttataa tagtaccaga gtaaacttca ggacagttta caacaactct ttctattggt
     1981 tccattagtt ttccatcttc tttatgcatt aaaacttcag gtttagaaac accaacttca
     2041 taaccttcac gtctcatatt ttcaagtagt atagataagt gaagctctcc acgtccagaa
     2101 actttgtatc catcagtagt atcaagaggt tcaactttaa gaccaacatt tacttcaagt
     2161 tctttttcaa gtctatcttt caaatgtcta gttgtaacga attttccact ttttccaacg
     2221 aatggagagt cgtttactaa gaagttcata gaaagagtag gctcttctat ttttatcatt
     2281 tccataggta gtggactatc taaatcgcat atagtttcac ctatagatat atcaggaata
     2341 ccagctataa caactatttc tccactagta gcttcatcaa cttcaacttg ttttaaacct
     2401 tcatacacag aaagttttga tacttttcct ttagatacaa cagaatcttc tctacatata
     2461 gcaacttgtg tattgttttt aagagtacct ttgtaaattc tacctatacc aagtctacct
     2521 acataatcat catatgcaag agctgatatt tggaactgta gaggttcatt atcgtaatta
     2581 ggataagctt caacgtgatt tacaatagtt ttaaatagag gagaaaggtc ttcactatca
     2641 tcatccattt caagtttagc aataccttgt ttagcaatac catatattat aggaaattcg
     2701 cattgctcat ctgttgcatt taagtctaca aataaatcga aaacttcatt aactacttct
     2761 tccgctctct ggtctttttt atcaatcttg tttataaata atattggttt taaaccgaac
     2821 tctaaagatt tttgtaaaac gaatctagtt tgaggcattg ggccttcact agcatcaact
     2881 aatagaataa ctgtgtcaac agttttcata acacgttcaa cttcagaaga aaagtcactg
     2941 tgtcctggag tatcaactat gtttattttg taatcttcat agtttattgc acagtttttt
     3001 gaatatatag ttatgcctct ttctttttca aggtcgttac tgtccataac gcagtcttta
     3061 actacttcgt tctttctaaa aacaccgctt tgagaaagga aagcatcaac caatgttgat
     3121 tttccagcgt caacgtgggc tataactgcg atatttataa ttttatgttt ttgtgacatt
     3181 tttgttgctc ccttcgatta aaataactta ttaattatag cacaatatat tattaggtac
     3241 aaggaggaat atattaaatt gtattaatat agtttaaatt ggataaaact gttagttttg
     3301 catctgaaaa ttattctgtt taaaaaaatt ttttagacaa ataataacct taatagataa
     3361 aaagattaat aaaagagtaa aggatgatat atgttggaag taaccaaaat aataattaaa
     3421 tattttgcaa gtgaaagtga tacttttgta aaagaagaag tttgtaattt tgaagaactt
     3481 cttaagtggt ctcataaatt tattgaaggt aaaaagatag aagatgtttt gtatataaag
     3541 tctaaagaaa actataaagt aaatgtgatt aagtctttag aaattaagga attggaaata
     3601 gtgagaaaac aacagatacc accgtacatg tagtattaat aatatataaa attaatatgt
     3661 aatactcgca ataggatata aatggtatat atggtaataa tttatattaa aaaaactttt
     3721 ataaagttta tatttgggta taaaagtatt aattagacat taattaggag gaacttaaat
     3781 atgataagag tatgtccaaa ctgttcaaat gtggatgtaa ataagctaaa aactttggtt
     3841 ggagaagaaa atgtaaagac tggttgtata ggtcagtgta gagcatttaa aaaagaagct
     3901 gttggaataa tagacaatga gcttgaaata aaggaaacag aagcagagtt ttttgaagca
     3961 tgtaaagaat aaattttaaa taaaatataa attataataa atagagcatc taaattgtat
     4021 aagcattaaa caatttagat gctctatttt tatatataca tttaattatg agtatacttt
     4081 tctattaaat acaaataaat ataactaata catttattta ttaaaaaaat attgatttaa
     4141 tatacctata gggggtataa tgaaaatata gatttctaaa taagtaattt atcaatatta
     4201 catatcaaaa taaaacgtta caaattagct gaaaatatat tgaaagaaag gaagatttta
     4261 ttatgagttc aaataaagtg gtagaaagtt ataaaattac aggtatgaca tgtgcagctt
     4321 gtgcaaaggc agtagagaga gtaactaaga agatggatgg agtatatgac caaaatgtaa
     4381 atatagctac tgaaaaactt aaaatagaat atgataattc taaggttaat tttgatgata
     4441 taaagcaggt tgtagaaaaa gcaggatatg gaattataaa ggaagaaagt aataaaaaaa
     4501 ttgatatgaa aattgatgga atgacatgtg cagcttgtgc aaaagctgta gagagagtgg
     4561 taaaaaaatt ggatggagta gaaagtatta gtgtgaatat tgcaacagat aaagctaata
     4621 tagactatga cccatcaaaa gtaaaattat ctcaaataaa agcagctatt gaaaaagctg
     4681 gatataaacc aatagaagag gtaagaaata aggttgatgt ggatgaagat aaattgagaa
     4741 aagaaagaga aatgaagtct ttatttgtta aatttatagt tgcaatagta tttgcagtac
     4801 ctctgtttta tatagcaatg ggacctatga taataaagcc tatagggcca tggcctttgc
     4861 cagaaattat aaatcctatg acaaatactt ttaattatgc attaattcag ttaattttag
     4921 taataccagt aatgatagct ggttataaat tttatataaa tgggtttaaa tcactttttt
     4981 ctttaagccc taatatggat tctttagttg caataggaac attagccgca tttttatata
     5041 gtctatatac gacactacaa atagccaatg gacaaattca aggtatgcac catcatcagt
     5101 tgtattatga aagtgcagga ataataatag cacttatctt acttggtaaa tatttagaat
     5161 caaaatcaaa aggaaaaaca tcagaagcaa ttaaaaagct tatggggcta caacctaaaa
     5221 ctgcaatagt gttagttgat ggtaaagaag ttgaaactcc tatagaagaa gtagagatag
     5281 gagatatact attagtaaaa ccaggaacta aaatacccgt ggatggagtt gtaatagaag
     5341 gatatacatc agttgatgaa tcaatgctta caggtgaaag tataccagta gaaaagaatg
     5401 ttggaagtaa ggtgacagga gctagtatta ataaaaatgg tgttattaag tttaaggctg
     5461 aaaaaattgg tggagatact gctcttgccc aaataataaa gttagttgaa gatgcacaag
     5521 gtacaaaagc acctattgct aaacttgccg atactgtatc tggatatttt gtaccaatag
     5581 taattgcaat agctgtagtt gcatcattat tgtggttttt aataggagga aaagatatag
     5641 tatttgtact tactatattt atatcagtac ttgtaattgc ttgtccttgt gcattaggat
     5701 tagcaacacc aactgctata atggttggga ctggaaaggg cgcagaaaat ggaatcttga
     5761 taaaaggtgg agaggcacta gaatctgcac ataaagtaaa tacagtgata tttgataaga
     5821 caggtactat aacagaagga aagccaaaag taacagatat agtattaaat aataatgtaa
     5881 aagaagaata tcttatcaag attgcttcaa gtgcagaaaa aggttcagaa catcctcttg
     5941 gagaagcaat agttaagtat ggagaagaga agaatataaa atttgaaaaa gttgataatt
     6001 ttaaagctat accaggtgct ggtatacaag ttactattaa tgatgaaagt atattacttg
     6061 gaaatagaaa gcttatgaat gacaataata taaagcttgg agatttagaa gaaaaatcaa
     6121 atatattggc aagccaaggt aaaacaccta tgtatatagc tgtagatgga aatttatcag
     6181 gtataatagc agttgcagat gtagtcaaag aaagtagtaa aaaagcaata gaaatacttc
     6241 atgatatggg aataaaagtt gcaatggtaa ctggagataa tgcgaaaact gcaaatgcta
     6301 tagcaaatca agtcggtata gatatggttt tggcagaggt tttaccagaa gataagtcaa
     6361 aagaagttga aaaactacaa aatcaaggaa agtttgttgc aatggtaggg gatggaataa
     6421 atgatgcccc agctcttgca aaagcagata tagggatagc aataggaagt ggaacggatg
     6481 tagccattga atctgcggat atagtactta tgaagagtga tttaattgat gttccaacag
     6541 caattaaact tagtcatgaa actataaaaa atataaaaca aaacctattt tgggcatttg
     6601 gatataatac aattggtata cctgtagcag caggaatatt atatgtattt ggaggacctt
     6661 tattaaaccc aatgattgca gcagcagcaa tgagcttaag ttcagtttca gtcgtatcaa
     6721 atgcacttag acttaaaaac ttcaaggcat ataagagaga ttagattaat aaattaaata
     6781 aaatgtatcc aaaagagcta tctttaaatt aaaaggatta atttacaaat taagatagct
     6841 cttttttcat gtaaaattca caacaataag ataaaatata agtaatatac gaaattttaa
     6901 ataaaataga aaggattgat agaatgaatt cgtcaatact tgtaattgaa gatgattcaa
     6961 atatacaaga gttaatatca gaatttttaa gtgcagaagg ttatcaagtt gatacagcaa
     7021 atgatgggtt ggaaggtata caaaagttta agcaaggaag ttatgattta gtaatattag
     7081 atataatgat gccaaactta gatggttatg gagtttgtaa aatgataaga aagtcatcaa
     7141 gcgttccaat tatattttta actgctttaa atgatgaagg agaccaactt aaagggtttg
     7201 acttagaatg tgatgattat ataacaaaac cattttcatt taatcttctt ataaaaagag
     7261 tagaagcaat tttaaggcga agtaacaaga ctataaatga caaatttata gtttttgaaa
     7321 aattaaaatt agatttaaac acatatattg cagagataga tggagaacct atagaactta
     7381 cactaaaaga gtttaatata ttaaaagctt tgatagaaaa gtatccacaa gttataacta
     7441 gggaaggtct tttggatagt atatggggtt atgactatta tggagatact aggattgttg
     7501 atgcacatat aaaaaatata agaaaaaaaa tatcattacc atatattaaa actgtaaaag
     7561 gaataggata tacacttgag aaggatattt gataagtggg aaaagttaag tataaagtat
     7621 aagttatttt caataacgac atcattatta atagcattag ctttaataat atatctaatt
     7681 ttatattttt tattgccatc atattatcat gagtataaaa ttgagtctct tcaagaaagt
     7741 ttgaaatctt tagtagatag ttcaattcat ttcgatacat atactttaga agaaagactt
     7801 tattatatgg ctaaagacca aaatttggct attttattaa aagataacca aggtaaaatt
     7861 gtatatggta agaatgaagt agttatttta agatatagta agtacatgat taatagtctt
     7921 gaggatgagt atagaacttc tatacctata tatactaaag atgcaaaaga tggtccatat
     7981 actttagaac tcgttatgcc attacaacca attgacgaag caaacgaagt tataagaaaa
     8041 ctaatgccat acatcatatc aatagcaata ttgatagcga ttattggagc atatatatat
     8101 tcaattgtaa taacaaagcc tcttataaac ataatagaga gtgagagaga acaggaatat
     8161 agaaggaagg attttgttgc tacaatatca catgaactaa aaactccaat aaccataata
     8221 agtggtcaaa ttgaaggtat gatttatagt gtaggtaagt ataaggatag ggatacttat
     8281 ctgaaaaaat cgtatgagtg tacacaagaa ttaaaagatt tagtaaatga aatgatagag
     8341 gtttcaaaat cagaaatact tgaaaaagat ttgaaattgg tatcaataaa tataagtgaa
     8401 ttattaaata gacttgtaaa gagacaagta tttttaatag aagaaaaaca tatgaaaact
     8461 attttaaaaa tagaagaaaa tttggaaatt aaagcagacc aagagagaat aactaaggca
     8521 atcaataata taataaataa tgccataaaa tattctcctg aagaatcaga gcttataatt
     8581 agactctatg ataaaaataa acgaataagt aaaaagactt ctaatcaaag agtggtttta
     8641 gaaattgaaa atactggtgt aactatcgag aaacgttatt tagaagaaat atttaatcca
     8701 ttttatagaa tagaaaaatc tcgttcaaga aaaactggag gaagtggact tggactttat
     8761 atagtcagcc aaatttttaa aagtcatggg tttgattata gcataaaaaa caaagaaaac
     8821 tctgtagtat tcacagtaga atttaaaaat taattactta ttataaagaa tatataactt
     8881 tcaataatag ttcattttaa aatcacaaaa aattcataat gaaactgtat tatataaata
     8941 taaagaagct taaaaccata aaatacacca actataatga tgagatttcc ttacatcctc
     9001 catataagtc atcattatag taacccaaca attaagttac tatgaattta aaaaataaca
     9061 ccgagcatat aatctatgct tagtgttatt tttattttga aataaaaaat atttaattta
     9121 ttgaaatgta tagatttaga tagtttaaac tatatttaag acttaaaaat tataattgat
     9181 attacaaata aatatatgta ctttgggaaa aataaatata ggaagtatta tatttacaga
     9241 ggaggtagtt ttgatggata gattaaaaag agatatgaaa aatatgaaag aagatttaaa
     9301 agaaggtgtt aaaaagacag cttatgttat gaaaaataca gctgaagatt tgaaagatga
     9361 tgcacaaggt gctatggtaa acttagaaat gaaaaaagat gagatgatgg aaagatatga
     9421 acaaaagaaa ttttctaaag aattagagaa gcaaatgaag aatgaaatga aataagcttt
     9481 tatttatgaa taacaaatta ttgtattcat ataaaaagta gccagtaata ttaaatagtt
     9541 tatttaagga aatagacttt ctaaaaataa ctgtattaga tttagaaagt ctatttcaaa
     9601 ttagttttat aaatagacat aaggataaag tagatgttat agaactagat tttaaaaaat
     9661 agatactaag gataaaataa atattataga aatatgtttt taagaatatt tatcaaataa
     9721 aaatttatat ttataagaaa tcctataaaa catataatta aacttataaa acatttacat
     9781 taaattctga taaaatatct actatatcag gagtaggcgt tttttctgta attatagaac
     9841 taatatcttc taaatgagca aacttgaaat ttccatcaaa tttaaacttt ttatcttcca
     9901 taactataaa tactttttta cttgaattta ttatagcctt cttcgtaaga ccatcttcaa
     9961 tttcaaaagt tgtaagtgaa gagttgaata catctactcc acaacttccc ataaaagtct
    10021 tatcaaactt atatttcgat ataaactcta tagttggagt accgacaaaa ccgtctaaac
    10081 tgagatttaa taaacctcca gtggaaatta tatttaaatt atttggtttt gaagtaacta
    10141 catttagtat atccagcata tttgtaacaa gtgttacttt tttattactt tcagctaaca
    10201 acttcgcaag caagatgtta attgtagaga tatctaaaaa tatagtttct ctatcttcaa
    10261 ttaaattaaa tgctttttct gctattattt tctttgttgg aatattaatt tcttttctgt
    10321 cttttgtatc ctgattctct agtgtttctc tagctagtac agctcctcca taaattcttc
    10381 ttattgaaga aatcttttct atatttttta aatcttttct tatacaatct tctgtaacat
    10441 taaatttaga actgagctct ttgacagtaa ctctaccttc tttttttagg atatttaata
    10501 tagcttggat tctttcttct gcaaacattt tctacctctt ttcgcaatat agtattatag
    10561 taaatattat aagataaaat acaatatatc aactatttta acatgaaata caaaattaat
    10621 ttaatataaa aagtatgttt tttctaacta tatatttaga atttagtaaa taaaaaaatt
    10681 ataaaactaa gaaggaaaag taaaacaata ataaaaaata aaaaacaata agcaaaatgt
    10741 tgaaaataat accaaatcaa tatataataa gaataaagaa agattaaagg gggatatttt
    10801 aatgcaacta atcttagata caggtaatgt ggaggagatt aaggagttat gtacttgttt
    10861 accaatagat ggtgtaacta caaatccaag tattgtttca aaagaaaaaa agaattttaa
    10921 gcaacttata aatgaaattg gtgagattat aggtgaggat atgcctatac atgctcaagt
    10981 gttaagtaca aagtatgaag aaatattaga agaagcatta tatataagta gtttgagaaa
    11041 aaatatatat gtaaaaatac ctgtaacaca agatggttta agagctataa aagaccttca
    11101 tagaaaaggt gtaaaaataa ctgctactgc aatattcact gctcatcaag gttttttagc
    11161 tgcaaaggct ggagcaaatt atattgcacc ttatgtaaat aggcttgata atatatctgg
    11221 tgatggagta gctatggttt cagaacttat aaaaataata gatacttata aaatggatac
    11281 aaaagtactt gcagccagtt ttaaaaatgc acaacaagtt atagaattaa tgcaacatgg
    11341 ggtgcatagt gttacagtac catatgatat ttgtaaatct atgatgaatc atccattaac
    11401 tgattggagt gtagataagt ttatagagga ttgggagaat acttttggaa aaggaagtaa
    11461 aacaaataat atttagtatt atggtaaaag agtagttttg tccaatttta caagaactta
    11521 tataaaaaga tgaaaatatg aattttcttt ttaataattt cgttattatc ttaagttaat
    11581 tcatattttc atctttttta gatttctagt cctataaatt tccaccaagg gaatgttata
    11641 catattatta taaagtaggt taaaggaatc aaagttaaac cgtatttgaa aataaccttg
    11701 ctattataca gattttcacc atgaccaacc attattgtag catgatgaaa tggtaatatg
    11761 tactgtatgc ttactataat gtagacaaat agacataaag taacactatt ttcctttagt
    11821 atatgtaaac ttccaagtaa tggtattact acagatgatg tagtgacagc acttccaaga
    11881 catatattca agattattgt gagagttatc aaaaacaata ttgaaataat ttctgaagag
    11941 tttggtataa actttatcaa ataatttccc attatatcta caactccaga gtactttaac
    12001 actcctccaa ttgaaaatgc tgctataaaa aaaataagga ccttccaatt tatttctttt
    12061 aaagtactaa atccaactat ttttcttagt aataaaagaa gtacacaaat tgacattata
    12121 attaatgtgt ttatgttatg tatgaactga gttaaaaaca taaaaaacat tattcctagg
    12181 cataaaaata cgtgtttttg ttctttgttt agcaaattaa attctttttt taaattagaa
    12241 tatgaaaaat gaagtttatt accctcaaga ttttcattag aaataaattt tattgaatgc
    12301 aattcttttt taaagacaaa ggtaaataaa aaataagtta taaaacaagt aattatagtt
    12361 ggaacagaca tataaaaagc ccattgaccc caatttatat tacaatttcc aagttctagt
    12421 acaacataat ttagaagagt gtctccattt acaaaaaaca ttgatgtaaa ggtagatgct
    12481 gtaaatatac taaataaaag tatagatttt gaatcttcag ttatctgttg ttcttttaaa
    12541 aactccttgt aaaaagcaga tacaagaata acccttggaa atggttgtgg gataaaaaat
    12601 attaaaagta tacctaaaat atacgataaa agaatcattt ttttaggggt atttacagta
    12661 tttaaaatta acttctcaga aataattttt gcgacacctg tttttgtaac tgcattagta
    12721 attatgtatg caagaattat tatgtaaaaa ttttctgtaa ataaaaactg taaaataacc
    12781 tttattggtg caatgttaaa tataaacgct agaattacaa aaaacaatgc aacaaaagtt
    12841 ttttcaactg agtctacagc ccatatcaag atagttaaaa aagataagca tatagaaaat
    12901 tttatgttga aactgtaatt aagagagaag tagagaatta tggtagctat aacagtcata
    12961 taaaattgtt ttggcttaag aataataccc atttttatat tcacctccat aatttattat
    13021 atcataatgg aggtgaatac aatgaatgtg aatacatttt ataaaaagat tattcattga
    13081 ttctatgatt tacaatagct ttagttttcc aatgtccttt cttatagtag ataactgtaa
    13141 caataagacc taaagtccaa ccaaaaggaa tacccatcca aattccgtct gttccaaaaa
    13201 atttagaaag catataagaa gctggaagtc ttccaagcca taaagatact attgagctta
    13261 taagtgcaaa catggaatca ccagcacctt tcattgcact tgaaagtaca aaagaagttc
    13321 caataaataa gaagaatggt cctattataa ataagtaaga agagccaatt ttaatgacat
    13381 ctttatcagt attgaataga gcaattagat tttccctaaa tagcaaaatt aaagcaataa
    13441 ctgtaactgc taaaactaag gtcattttta tagattctcg aatgcctttt ttaactcttt
    13501 cattttctcc agcacctatg ttttgagcaa caaaagtaga aacagcagaa ccaagattca
    13561 taataggtaa gcttataaaa ttttctatcc taagaccagc accaaaagct gccatagcag
    13621 atgtaccata actattaact aaaaattgaa gagccatatt tccaattgaa aacaacattt
    13681 gttgaactcc acttggaagt cctaatctaa gtccatcttt aaatattttg ttatcatata
    13741 caattccctt gattttaaat ttaagcactt catgtttttt atttaaataa attatactta
    13801 ttataaatga tactgcctga gccattatag tggcaagtgc aacgccctca acacccattc
    13861 ttagcactac aataaaagtt aagtctaaaa ctatatttag aattgtggct attatcagaa
    13921 aataaagtgg agttactgaa tctccaagtc ctctaagtat tgcacttact gaattatatc
    13981 cagcagaaaa taatattcca ctaaatatta tagtaagata caattttgat tgagcaaaaa
    14041 cggattctgg tgtattcata agcttaagca ttgggccacc aaatactatt ccaagaatac
    14101 ttattaatat agaaccaata aataaaagta tatatgtagt atcaatagta gcttttacct
    14161 tttttaaatc tcctgagcca taaaattgtg acactaaaat agaaaatcca aggctaacac
    14221 ccataagcgc tgccaccaat aaaaacatta tagggttagc tccagagact gccgccattg
    14281 cttcttttcc aataaatcta ccaactatta tactgtcagc tgtattgtat agttgttgaa
    14341 ataaactacc aataagcata ggcatggcaa aaaagaatat ggactttccc tcatgacctg
    14401 tagttaaatc tttcacctta ttcctccaaa taaaaaaatt attaatttat tatagtataa
    14461 tcttaacata aactttatat ccaaactata aataaattgt atcaaaatat catatatttt
    14521 tttaaaatgt aaagaatata attataattt gaatttaata aatcaatatt taata
//
LOCUS       DAEPID010000090        14501 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.090, whole genome shotgun sequence.
ACCESSION   DAEPID010000090 DAEPID010000000
VERSION     DAEPID010000090.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 14501)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 14501)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..14501
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.090"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            933..2291
                     /locus_tag="KR257_003184"
     CDS             933..2291
                     /locus_tag="KR257_003184"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424358.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="purine/pyrimidine permease"
                     /protein_id="HBH0031855.1"
                     /translation="MKAKSTSKFELDGIPPLKEAIPLGLQHLMAMVIGSCLPAILIAN
                     AAGLNHKMSTLLIQAALVFAGLSTLLQLYPIPLFKGFKLGGGIPVIMGATAMFIGAGV
                     SVASKYGLPVLFGSQIIAGIVIIIIGFGLKKIRFIFTPAVSGTIVACMGLGLFPIAIK
                     NLAGGMGNETFGNPINFIVGISVSLMILGLNKYGKGLFKDASILVSIIFGYILSLILG
                     IVNFSSIQEFTLVALPKPLAFGLDIRLEVVVMFSIIYLVEIADIMGACTLSAVGGLNR
                     QVTDEELSSAVLGNGVLSTIGALFSATPMGMFGQNSAIVSNTKVVSKFVLAIGGIGLF
                     LAGISPLLANLIRTIPPCVVGGATLVIFSTLTTSGLRLVSMDGFNQENSMILGLSMAS
                     GIGFMVAPQVLEKFPKFIETLLADSSVVSGAMVAIIIQALYMVKFPGNKSDKVEDKNK
                     SL"
     gene            2398..3192
                     /locus_tag="KR257_003185"
     CDS             2398..3192
                     /locus_tag="KR257_003185"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893424.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="FAD binding domain-containing protein"
                     /protein_id="HBH0031856.1"
                     /translation="MVTIKEYSVPQSLEEAYKILISKKNNVILGGCGFIKLSNKNIGT
                     AIDLKDINLNYIKEDKKNILIGADTSLRSLEIDKTIKNYCSGILSSAVSNIVGVQFRQ
                     GARIGASVFSKYGFSDLIPALLVVGAKVRLYNKGILELSEFLDSELSRDILVEVILPK
                     KDAIAVFDSIRKCTGDFSVLNSAMLKENDTYKIAIGARPQKARLALEASNILNKEKDI
                     DKASIVASKELTYGSNMRASKEYRKDMASALVKRMYNAIEEGMYND"
     gene            3185..5491
                     /locus_tag="KR257_003186"
     CDS             3185..5491
                     /locus_tag="KR257_003186"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890192.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="molybdopterin-dependent oxidoreductase"
                     /protein_id="HBH0031857.1"
                     /translation="MINKGIRKIDSTAIVTGKPLYTEDLIMHKDVLTLKLLRSPHAHA
                     KIKNIDTSKAEKIPGVVGIYTYKDVPQVRYCVPGQTEPEASPYDRVLLEDTVRFIGDE
                     VALVAAEDEKTALKALKMIKVDYEVLKPVFDAREAEGNEVVIHPEKDIVEPYPFGLDA
                     KNNIVSKEFFEFGDVEAKLKESDFVVESSYKTQSQSHCMMETHRSYSYKDINDRIVVV
                     SSLQSPHNVKRILRKVLGIPSSKIRVIKPRIGGGFGGKNIAATDIFTAFVTMKTGRPA
                     KFVFTRSETFVGSNSRHEMFFDVKVGADKEGNLKAIELKSLNNTGAYGGNGVSVSSES
                     GHNTLPIYNDIDAVRFNARTVYTNRLPAGALRGYGATQGIFAIDSAIDELAHKIGMDP
                     LEFRIKNIIDRYTNGKAAEDEILSCELRQCIEKGKKLINWDDKYPCKDIGNNKVRAVG
                     MAVANHGSGIPRVDMATVTIRMDEDGTYKLLSGLADLGQGADTIQAQIAAEALNTTVD
                     RISIYTGDSDLCPYDTGAFASCTTTVTGNATIKTANKLKDILLSVAESKLGFKKEDLE
                     LGKDRVFVKNDNSKFVLLEELGRESVGGIGFASDDVPVVLEATESFGMLKKIKPFIAG
                     FAEIELDKNTGEYKVINFACVPDCGTVINPTLARIQVEGGVMMGIGFAMYEDPIFDKD
                     GRLLTDSFLQYKVPTKKEVGNILVDFAENFDPGGPYGAKSLGEIVIHTPAPAIANAIF
                     NATGVRLRELPMTFEKVYMGMKNNNKQL"
     gene            5630..6907
                     /locus_tag="KR257_003187"
     CDS             5630..6907
                     /locus_tag="KR257_003187"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009905725.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
                     /protein_id="HBH0031858.1"
                     /translation="MSNRIKNIHYGTQRQQLKNLTKKEYQALREMCFLAKNLYNVGTY
                     NVRQHYFNQGEHLNYEANYHVCKENENYKLLNSNIAQQILKEVDSSFRSFFGLIKLAK
                     EGKYDFRGIKSPKYLDKEGFFSIIIGQIRIKEDGILNVPMSPAFKKLYGKVSIKVPQN
                     ILEKKIKEIRIIPKHKARFFEIQYCYEIPKSEEVSNQKNALAIDLGLENLCTCVTNLG
                     DSFIIDGKRLKSVNQWANKQNDKIEALKLKKNITAITRKQFKVWNKRNNQVKDYVNKT
                     CFYIIDYCVKNNIGNLIVGYNAKLEKSDNMERKIYRNFIRIPFGEIKGKLEYLCKIKN
                     INFIRQEESYTSKSDFFADDFLPDINVDNVKKYDFKGERITRGQYKSSVGIIINADVN
                     ASLNILKKSQVVNLSNLQNNPQILKQPQRVRIS"
     gene            7090..7812
                     /gene="yqeC"
                     /locus_tag="KR257_003188"
     CDS             7090..7812
                     /gene="yqeC"
                     /locus_tag="KR257_003188"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435113.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="putative selenium-dependent hydroxylase
                     accessory protein YqeC"
                     /protein_id="HBH0031859.1"
                     /translation="MELSNIIEKNEIITVVGAGGKTSFINYFANFYRDKLKVLLTTTT
                     KIYVPNDYDNIIITIDGTVIPSICHGITVCGSYINNENKLVSIDSSILDEIVDQFDLV
                     LIEGDGSKRKKLKGWNAKEPVVYHKTTKTIGILDITSFGMNINEENIHRVEIFKKIAN
                     LDTSSINSSSTVSIENLKNIVLNPNGLFKNYSGKRVLFINKVENEKYKNLAIKLVENI
                     KEYESEIEIFYGSVKQKFCVRY"
     gene            7919..8488
                     /gene="mocA"
                     /locus_tag="KR257_003189"
     CDS             7919..8488
                     /gene="mocA"
                     /locus_tag="KR257_003189"
                     /EC_number="2.7.7.76"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890188.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="molybdenum cofactor cytidylyltransferase"
                     /protein_id="HBH0031860.1"
                     /translation="MINAVIMASGFARRMGANKLLLNYKGCSIIEHVFREVSKIDFHQ
                     VVVVSQYEEVLLLCNKYGFEYIDNKNANIGQSESIKLGVLNSSKCDGYMFFVGDQPFI
                     DNLYIDKIINTFKLDRDFIVIPRYKDMCGNPVIFPYSKKEELLALKEDEKGKTILKNS
                     SKIKYVEVPKEMLFDIDTKMDYERIGGKL"
     gene            8485..9504
                     /locus_tag="KR257_003190"
     CDS             8485..9504
                     /locus_tag="KR257_003190"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429005.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="molybdopterin-binding protein"
                     /protein_id="HBH0031861.1"
                     /translation="MKLIKTIDAVGQVLCHDITQIIPGEFKGRKFKKGHIVKEEDIPV
                     LLSLGKDNLYVWEKSEGMVHENEGALFLKELTAGENLDFSEIKEGKIDFIAACDGLLK
                     IDVDALFDLNCVGEIMMATLHNNFIVNKGLKVAGTRVIPLVIDEKKLEDAKKVVGNRK
                     IVNVVPFKPKKVGIVTTGNEVFYSRIVDKFGPVIEEKVKGFGCEVIGQTICPDDKEII
                     KSAIKEFISQGAELICCTGGMSVDPDDVTPTAIKETGADLVTYGSPILPGAMFLLAYY
                     GEVPIMGIPGCAMYHKTTVFDIVLSRVLIDEKLDKYDIARYGHGGLCMNCDVCTYPAC
                     NFAKI"
     gene            9842..11467
                     /locus_tag="KR257_003191"
     CDS             9842..11467
                     /locus_tag="KR257_003191"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729371.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="HBH0031862.1"
                     /translation="MLQVTGVGLRFGDKELFKDVNLKFTKGNCYGIIGANGAGKSTFL
                     KILSGEIEPNTGSISITDKERMSVLKQDHFEYEEETVLNVVIRGHERLWNIMKEKDAL
                     YMKEDFNEEDGIKAAELEGEFAELDGWDAETNAEKILMGLGITKDMHYKQMKELVGGE
                     KVKVLLAQSLFGKPEILLMDEPTNHLDFKSINWLNNFIMDLEESIVIIVSHDRHFLNQ
                     ICTNIVDVDFGKIQMYVGNYDFWYESSQLALQLAKDQNKKTEEKIAQLKEFIARFSSN
                     ASKAKQATSRKKQLEKLEVEDIQPSRRRYPYVGFTPAREIGNEVLEVHNLTKTIDGVK
                     VLDNVSFRLDRDDKVVFMGDEIATTALFNIVMGELEPDSGEYKWGVTTSQDYLPKNHN
                     KFFDGVEYSLVDWLRQFSEEKSESFIRGFLGRMLFSGEEALKEAQVISGGEKVRCMLS
                     KLMLSNANVLVLDDPTNHLDLESITSVNKGLEKFPGVLLFTSHDHEFISTIANRIIEI
                     TPNGIMDRKMDFDEYLESKEIQDQLAKMYGKDK"
     gene            11666..12142
                     /locus_tag="KR257_003192"
     CDS             11666..12142
                     /locus_tag="KR257_003192"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435120.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0031863.1"
                     /translation="MVKKRLVAVVISLAMISVGNFSYAHSGGHNSSGDHHNKNKSELT
                     RYYCGGHSAHQHNKGFCPYASTKENSGVTISSVHNEKNHKNYFAEKGYNKGYEDGCKG
                     LYNLSVTEAKSDNLYEKEILKSSYEKGYLIGYNEYKAKKVDDVMKKMLDIPMLASI"
     gene            complement(12350..13462)
                     /locus_tag="KR257_003193"
     CDS             complement(12350..13462)
                     /locus_tag="KR257_003193"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009905716.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tyrosine-type recombinase/integrase"
                     /protein_id="HBH0031864.1"
                     /translation="MNAFIRKRNKNYVVYLEFEDEKTGKRKQKNMGTFDKKREASKRL
                     NEVKESLYNDGFLVPSEITVSEFLLDFLNKYSENISLATYNNYVSICKNYINPSIGKY
                     KIQDLHPVHIQNYIDKLSYKLNPQSIKIHINILKLAIKRAYRLKLIKENVMDSIEAPR
                     YKKFKNEIYDREQMIKLLDLAKNTEMELPINLAIGLGLRISEVLGLTWDNIDFEENTI
                     TVNKITSRINGSVILKEPKTESSVRKISSPKELMSLLKEYKIKQNKNLLKSSIRNNNN
                     LLFFNKKCEPIAEDVMSKKFKRFLEKNELPHIRFHDLRHSHVTLLINSKVPIKVISER
                     VGHSNISTTLSVYSHVLKEMDKEASDKISESLFNAN"
     gene            13803..14180
                     /locus_tag="KR257_003194"
     CDS             13803..14180
                     /locus_tag="KR257_003194"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428999.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="BlaI/MecI/CopY family transcriptional regulator"
                     /protein_id="HBH0031865.1"
                     /translation="MTITKIPPAELKVMKFIWSSDFTVASKDVIEAMEKLYNWKQTTT
                     LTLLSRLVNKQFLSARKIDRHTHYTVLIGEEEYLHFETKTFLDNMHGSSIESFMKSLF
                     KKGVNEEELNSVEKWVKDIKKDE"
BASE COUNT         5671 a         1500 c         2563 g         4767 t
ORIGIN      
        1 gatacaaata tagtaaagga gagtacattg gtacaactga gatacatagc ttattaagtt
       61 tttctgtctt atgagaatta tattataaaa tattcataaa tattttgagt ttaaattaaa
      121 taattatttt atgcttagat taattgatat ttaattaatt taataacaaa aacagtgaaa
      181 gagtaaataa tattatttac agggggtaaa gcaaagtatg ttaaataaat tgtacttttg
      241 gccccgtaca tagagaaatc tatgtaggac acaactttaa aaccagtaaa tcctaaagcc
      301 ttgcaactac aataaaagat agaaagaaac ttttatgaat gtggtgaaaa ccagaaacaa
      361 tagtgaggat ggtatatggt gagagcctaa gtacttaaaa atggacattt ggtcgccaag
      421 cctagaaata ggaaggtcaa acgactatct cgagagagag tacactataa gcgattgata
      481 gtggaaacgg gttgctctta gcaggtaatg ctgaagatga agaaatagtc tacgctcata
      541 tgaaagtatg aggtcactgg atttgaagtg acatctataa agtagcgttt ataggtaaat
      601 gtttaaaact tgaaacatgt aaatacttat gaaaacttat aacttataat gattaagatt
      661 gaaagattta aattgaatta aatttactat aaaaaattaa aaattcatag ctataatact
      721 cttatatttg taaagcatgg tatataatgt atacaaaatt aaagaatacg tttatttgtt
      781 aataattaaa tttattgcat ctgtttttta agactaaaaa cttaaatata tgttggagta
      841 tagttgatat ttatgaacat cattaattta atatattaga tttttaagta tttatataat
      901 tcaataagtt ttatgtaacg ggagttttta ttatgaaagc aaaaagtaca tcaaaatttg
      961 aattagacgg aataccacca ctaaaggaag caataccttt agggttacaa cacttaatgg
     1021 caatggtaat aggtagttgt ttaccagcga tattgattgc aaatgcagct ggacttaatc
     1081 ataagatgtc aacattattg attcaagccg cattagtttt tgcaggatta tcaactttat
     1141 tacaattata tccaatacct ttgtttaaag gttttaaatt aggaggagga ataccagtta
     1201 taatgggagc tacagctatg tttataggag ctggggtatc tgttgcaagt aagtatggac
     1261 taccagtatt atttggctct caaataatag ctggtatagt aataattata attggttttg
     1321 gtcttaaaaa aatacgattt atatttactc cagctgtatc aggaacaata gttgcatgta
     1381 tgggtcttgg actttttcca atagctataa aaaacttagc tgggggtatg ggcaatgaga
     1441 cttttgggaa tccaattaat tttatagttg gaatatctgt atctcttatg atattaggat
     1501 taaataagta tggaaaagga ttatttaaag atgcatcaat attagttagc ataatttttg
     1561 gatacatttt atcattaatt ttgggtatag taaatttttc ttcaattcag gagtttactt
     1621 tggttgcact tccaaaacca cttgcttttg ggctagatat aagacttgaa gttgttgtaa
     1681 tgttttcaat aatatattta gttgagatag ctgatataat gggtgcttgt acactttctg
     1741 cggtaggagg gcttaataga caagtaacag atgaagaact ttcttctgct gttttaggaa
     1801 atggagtact ctctacaata ggtgcattat tttctgcaac tccaatgggg atgtttggac
     1861 aaaattctgc aatcgtttcc aatacaaagg ttgtaagtaa atttgtacta gctattggag
     1921 gaattggatt atttttggca ggaatatcgc ctttattagc taatttaata agaacaattc
     1981 ctccctgtgt ggttggagga gcaacactcg ttatattttc aactcttaca acatctggtt
     2041 taagacttgt tagtatggat ggatttaatc aagaaaatag catgatatta ggtctttcta
     2101 tggcttctgg tattggattc atggtagctc ctcaagttct tgaaaaattt ccaaaattta
     2161 tagagacatt acttgcagat tcaagtgtag tttcaggagc aatggtagcc ataataattc
     2221 aagctttata tatggtaaaa tttcctggaa ataaaagtga taaggttgag gataaaaata
     2281 aaagtttata atgtaaaggt ttaatatatg tgaattaaat atactacaat tataaatata
     2341 aataaaagat ttattaaaaa cttttgtgtt ttaataagtt aatgatgggg ggataagatg
     2401 gttactataa aggaatattc agttccacag agtttagaag aagcatataa aattttaatt
     2461 tctaaaaaaa ataatgttat tttaggtgga tgtggattta taaaattaag taataaaaat
     2521 ataggaacag cgatagattt aaaagatata aatctaaatt atataaaaga ggataaaaaa
     2581 aatattttga taggtgcaga tacttcactt agaagtttag aaattgataa aactataaaa
     2641 aattactgta gtggaatact ttcaagcgct gtttctaata tagttggtgt tcaatttaga
     2701 caaggggcta gaattggtgc aagtgtattt tcaaagtatg gcttttctga cttaatacca
     2761 gcgcttttgg ttgttggagc gaaggtgaga ttatacaata aaggaatact agagttaagt
     2821 gagtttttgg atagtgaatt aagtagggat atattggtcg aagtaatact accaaaaaaa
     2881 gatgcaatag ctgtttttga ctcaataaga aaatgcacag gagatttttc tgtattaaat
     2941 tcagcaatgc taaaagaaaa tgatacttac aaaatagcaa ttggggcaag acctcaaaaa
     3001 gctagattag cacttgaagc gagtaatata ttaaataaag aaaaagatat agataaggca
     3061 tctattgttg ctagtaagga acttacttat ggaagtaata tgagagctag taaagagtac
     3121 agaaaggata tggcaagtgc attagttaaa aggatgtata atgctattga ggagggaatg
     3181 tataatgatt aataagggga taagaaagat agatagtaca gcaattgtca caggaaaacc
     3241 tctatatact gaagacctca ttatgcataa agatgttttg acattaaaac tacttagaag
     3301 tccacatgct catgctaaga taaagaatat agatacatca aaagccgaaa aaattccagg
     3361 ggttgtgggt atttatacgt ataaagatgt accacaggtc agatattgtg tgccaggtca
     3421 aacagaacca gaagcatcac cttatgatag agttttactt gaagatacag ttagatttat
     3481 tggagatgaa gtagctttag tggctgctga agatgagaaa acggcactta aagccttaaa
     3541 aatgataaag gtagattatg aggttttaaa gcctgtgttt gatgcaagag aagcagaagg
     3601 aaatgaagtt gttatacatc cagaaaaaga catagtagag ccatatcctt ttggattgga
     3661 tgcaaaaaat aatatagtat caaaagaatt ttttgaattt ggagatgttg aagctaagct
     3721 taaagaaagt gattttgtgg ttgaatcttc atacaaaacc caaagtcaat cgcattgcat
     3781 gatggaaact cataggtcat attcatataa agatataaat gatagaattg ttgtagtttc
     3841 atcattacaa tcaccacaca atgtaaagag aatacttaga aaagtattgg gtataccatc
     3901 ttcaaaaata agagtaatta aacctagaat aggtggtgga tttggaggaa agaatatagc
     3961 agcaacagat atatttactg catttgttac tatgaaaact ggtagaccag caaaatttgt
     4021 atttacaaga agtgaaactt ttgtaggttc taatagtaga catgaaatgt tttttgatgt
     4081 taaagttggt gcagataaag aaggaaattt aaaagcaata gagctaaagt cattaaacaa
     4141 tacaggtgct tatggtggga atggtgtctc tgtttcttcc gaatctggac acaatacctt
     4201 accaatatat aatgatattg atgctgttag atttaatgct agaacagtat atactaatag
     4261 gttaccagca ggagcactta gagggtatgg tgctacacag ggaatatttg caatagatag
     4321 tgctattgat gaattggcac ataagattgg aatggatcca cttgaattta gaattaaaaa
     4381 tataatagat aggtatacca atggaaaagc agctgaagac gaaatattaa gttgtgagct
     4441 gagacaatgt atagaaaagg gcaagaaatt aattaattgg gatgataaat atccatgtaa
     4501 agatatagga aacaacaaag taagagcagt aggtatggca gtagcaaatc atggttctgg
     4561 tataccgcgt gtagatatgg caacagtcac tataagaatg gatgaagatg gcacatataa
     4621 actattatct ggtcttgctg acttaggtca aggggctgat acaattcaag ctcaaattgc
     4681 tgcggaagct ttaaatacta ctgtagatag aatttctatt tatacaggtg attcagactt
     4741 atgtccctat gatacaggag catttgcttc ttgtacgaca acggttacag gaaatgcaac
     4801 aataaagaca gcaaataaat taaaagatat attactttca gttgcagagt caaagctagg
     4861 atttaaaaaa gaagatttag agttgggaaa agacagggtt tttgttaaaa acgataatag
     4921 caagtttgtt ctattagagg aattgggtag agaatctgtt ggaggaatag gatttgctag
     4981 tgatgatgta ccagtagttt tggaagcaac agaatctttt ggcatgttga aaaaaataaa
     5041 accatttata gcaggatttg cagagataga attagataaa aatacaggcg aatataaagt
     5101 cataaatttt gcatgtgtac ctgattgtgg aacagttata aatccaactt tagctagaat
     5161 acaagtagaa ggtggtgtga tgatgggtat agggtttgca atgtatgaag accctatatt
     5221 tgataaagat ggtagattat taacagatag tttcctacag tataaagttc ctacaaaaaa
     5281 agaagttgga aatatattgg tagattttgc tgagaatttc gacccaggag gtccttatgg
     5341 tgctaaatca ttaggagaaa tagttataca tacaccagca ccagctatag caaatgcaat
     5401 atttaatgct acaggagttc gtttaagaga gcttcctatg acttttgaaa aagtttatat
     5461 gggtatgaaa aataataata aacaattata ataaataata atgtgtataa aagcaagtaa
     5521 atttaaatta ttttgtaaaa taaagtaatt aaatggacat tatatatggt gttttgtaaa
     5581 aataccgtat ataatgtcta gtagagtata ttctaaagga ggtgagttca tgtcaaacag
     5641 aataaaaaat atacactatg gaactcagag acaacaatta aaaaacttaa ctaaaaaaga
     5701 atatcaagct ctacgagaga tgtgcttctt agctaagaac ttatataatg ttggtacata
     5761 taatgtaaga cagcattatt tcaatcaagg agaacatctt aactatgaag ctaattatca
     5821 tgtatgcaaa gaaaatgaga actataagct tctcaatagt aatatagcgc aacaaatatt
     5881 aaaagaagta gacagttcgt ttaggtcatt ttttggatta attaaattag ccaaagaagg
     5941 aaaatatgac tttagaggga taaaatcacc taaatattta gataaagaag gattttttag
     6001 cataataata ggtcaaataa gaatcaaaga agatgggatt ttaaatgtac ctatgtctcc
     6061 agcatttaaa aaactatatg ggaaagtaag tataaaagtt ccacaaaata tactagagaa
     6121 aaaaattaaa gaaataagaa taatacctaa acataaagct aggttctttg aaattcagta
     6181 ttgttatgaa ataccaaaat cagaggaagt ttcaaatcaa aaaaatgcac tagctataga
     6241 cttgggttta gaaaatttat gtacatgtgt taccaattta ggtgatagtt ttatcataga
     6301 tggaaaaagg ctaaaatctg tgaatcagtg ggcaaacaaa cagaatgata aaatagaagc
     6361 cttaaaatta aaaaagaata taactgcaat aacaagaaaa caatttaaag tttggaataa
     6421 gagaaataat caagttaaag actatgtaaa taaaacctgt ttttatataa ttgattattg
     6481 tgtaaaaaat aatattggaa atttaattgt aggatataat gctaagttag aaaaaagtga
     6541 taatatggag agaaaaatat atagaaattt tataagaatc ccatttggag agataaaagg
     6601 aaaattagaa tatctgtgta aaataaaaaa tatcaatttt attaggcaag aagaaagcta
     6661 tactagtaaa tcagattttt ttgctgatga ttttctacct gatatcaatg tggacaatgt
     6721 taaaaaatat gactttaaag gggaaagaat aacgcgtgga cagtacaaat ccagtgttgg
     6781 aatcattata aatgcagatg taaatgcgag tcttaatata ctaaaaaaat cacaagtagt
     6841 taatttatct aatttacaga ataatcctca aatattaaag caaccacaga gagtaagaat
     6901 atcttaatta tatttaaaag ataaactgat agcgtaagct tacagcttag cggcgaattg
     6961 gatccgcctt gttgtttaca acagaatcta tttactttcg agtttatgga atttcaaaaa
     7021 tcacttttac taaaaaggtc taactataat aattaagaga ttagaaaact ggttataaga
     7081 ggtgaaagtg tggaactatc aaatataata gaaaagaatg aaataataac tgtagttgga
     7141 gcaggaggaa aaacttcgtt tataaactat tttgcaaatt tttatagaga taaattgaaa
     7201 gttctcctta caacaacaac taaaatatat gtaccaaacg attatgacaa tataattatt
     7261 acaatagatg gaactgttat tccatctatt tgtcatggaa taacagtctg tggcagttat
     7321 ataaataatg aaaataaatt agtaagtatt gattcctcta ttttggatga aattgtagac
     7381 caatttgatt tagttttaat agagggagat ggctcaaaga gaaaaaaact taaaggttgg
     7441 aatgctaaag aaccagtagt atatcataaa actacaaaaa ccatagggat attagatata
     7501 acatcatttg gaatgaatat taatgaagag aatatacata gagtagaaat atttaaaaaa
     7561 atagcaaatt tagatacaag tagtattaat agtagttcta cagtaagtat tgaaaactta
     7621 aaaaatatag tattaaatcc aaatggatta tttaaaaatt attctggaaa aagagtatta
     7681 tttattaata aagttgaaaa tgaaaaatat aaaaatttag ctataaaatt agtagaaaat
     7741 attaaagaat atgaaagtga aatagagata ttttatggaa gtgtaaaaca aaaattttgt
     7801 gtaagatatt gaagtattaa aatagtttat atgatattat atatatagat aatatcaata
     7861 gagatattat aaaaatcata gaactatcaa tatattataa ataccaagga tgatatatat
     7921 gataaatgca gtgataatgg catcaggctt tgccagaaga atgggagcaa ataaactttt
     7981 attaaattat aaaggctgtt ctataataga acatgtattt agagaagtta gcaagattga
     8041 ttttcatcaa gttgtagtag taagtcaata tgaagaggtt ttgttattgt gtaataaata
     8101 tggttttgaa tatatagata ataaaaatgc aaatataggt caaagtgaat ctataaaatt
     8161 aggagtttta aatagctcaa aatgtgatgg ttatatgttc tttgtaggag accagccatt
     8221 tattgataac ttatatatag ataaaattat aaatactttt aaattagata gagattttat
     8281 agtaattcca agatacaaag atatgtgtgg aaatccagtc atattcccat atagtaagaa
     8341 agaagaattg ttggcactta aagaagatga aaaaggtaaa accattttaa aaaattcatc
     8401 aaaaataaag tatgtagaag ttcctaaaga aatgttattt gatatcgata caaaaatgga
     8461 ttatgagaga attgggggta aattatgaag ctaataaaaa ctatagatgc tgttggacaa
     8521 gttttatgtc acgacataac tcaaataata cctggagaat ttaaaggaag aaaatttaaa
     8581 aagggccaca tagtaaaaga agaagatatt ccagtgttat tatctcttgg taaagataat
     8641 ttgtatgtat gggaaaagtc agaaggaatg gttcatgaaa atgaaggcgc attgttttta
     8701 aaagaactaa ctgctggaga aaatttagat tttagtgaaa taaaagaagg gaaaatagat
     8761 tttatagcag catgtgatgg tctattaaag atagatgttg atgcactttt tgatttgaat
     8821 tgtgttggag aaataatgat ggctactctt cataataatt ttatagtaaa taaaggttta
     8881 aaagtagctg gaacaagagt gataccttta gttatagatg agaaaaaatt agaagatgca
     8941 aaaaaagtag ttggtaatag aaaaatagta aatgtagtac cttttaaacc taagaaagta
     9001 ggaattgtta ctacaggaaa tgaagtgttt tatagcagaa ttgttgataa atttggaccc
     9061 gtaatagaag aaaaagtaaa aggctttggt tgtgaagtta taggacagac tatatgccca
     9121 gatgataaag aaattataaa gagtgcaata aaagaattta taagtcaagg agcagaactt
     9181 atctgttgta ctggtgggat gagtgtagac ccagatgatg ttacaccaac agctataaaa
     9241 gaaactggag ctgatttagt gacatatggt tcaccaatat taccaggagc tatgttttta
     9301 cttgcttatt atggagaagt tccaattatg ggtataccag gatgcgcaat gtatcacaaa
     9361 actacagtat ttgatatagt tttatctagg gttttaattg atgaaaagct tgataagtat
     9421 gatatagcta gatatggtca tggtggcctt tgtatgaact gtgatgtatg tacttatcct
     9481 gcatgtaatt ttgctaaaat ataaagttat taaaaaagag tatttacaaa ttaagtactc
     9541 tttttaaata tgaaacaaaa cagctagaat gatgttttaa gaaaagcata tttatttaga
     9601 aattataata acttattttc aatgtgtaaa agaatgaata aagttgcaat ttgatttctt
     9661 tataagtata atataagaga ttgttaattt ttataaattt acaattttta gtattatttt
     9721 aataaatatt tcacaaattt agtataaaaa atatactatt tacgtgataa tatataataa
     9781 aaatgttatc aaagttttat gataaaataa attatgagca aaaagaaagg aaaatatatt
     9841 aatgttacaa gttacaggtg ttggacttag atttggtgat aaggaactat ttaaagatgt
     9901 taacttaaaa ttcactaaag gtaattgcta tggaataata ggagctaatg gtgcgggaaa
     9961 atctactttt ttaaaaatat tatcaggaga aatagagcct aatacaggta gtatatctat
    10021 aactgataaa gaaagaatgt cagttttaaa acaggaccac tttgaatatg aagaagaaac
    10081 tgttttaaat gttgttataa gaggtcatga gagactttgg aacataatga aagaaaaaga
    10141 tgcattgtat atgaaggaag actttaatga agaagatggg ataaaagctg ccgaacttga
    10201 aggtgagttt gcagagcttg acggatggga tgcagaaact aatgctgaga aaatacttat
    10261 gggtcttggc ataacgaaag atatgcatta caaacaaatg aaggaactag ttggtgggga
    10321 aaaggttaag gtattgttag cacaatcact ttttggtaag cctgaaatac tattaatgga
    10381 cgaacctaca aaccacttag attttaaatc aataaactgg ttaaataatt ttataatgga
    10441 tttagaagaa tctatagtta taatagtatc acatgataga catttcctaa atcaaatatg
    10501 tactaatata gttgacgtag attttggtaa aatacaaatg tacgttggaa actatgattt
    10561 ctggtatgag tcaagtcaat tggctttaca actggctaag gaccaaaata aaaagactga
    10621 agaaaagata gctcaattaa aggaatttat agctagattt agttctaatg cttcaaaggc
    10681 taaacaagca acatcaagaa agaaacagtt agagaaatta gaagttgaag atatacaacc
    10741 atcaagaaga agatatccat atgtaggatt tacacctgca agagaaattg ggaatgaagt
    10801 tttagaagta cacaatttaa ctaaaactat agatggggtt aaggttcttg ataatgtgtc
    10861 atttagattg gatagagatg ataaagtagt atttatggga gatgaaatag ctactactgc
    10921 acttttcaac atagttatgg gagaacttga accagacagt ggagagtata aatggggagt
    10981 aactacttct caagattatc ttccaaaaaa tcataataag ttttttgacg gagtagaata
    11041 ttctttggtt gactggctta gacagttctc tgaagaaaaa agtgaaagtt ttataagagg
    11101 atttttaggt agaatgttat tctcaggtga agaagcatta aaagaagctc aagttatatc
    11161 tggaggagaa aaggttagat gtatgcttag taagctaatg ctttcaaatg caaatgtact
    11221 tgtattagat gaccctacca accacttaga cctagaaagt ataacttctg taaataaagg
    11281 acttgaaaag ttcccaggag tgcttttatt tacttctcat gaccatgaat ttatatctac
    11341 tatagcaaat agaattatag agataactcc aaatggaata atggatagaa aaatggactt
    11401 tgatgagtat ttagaaagta aagagataca agaccaatta gctaaaatgt atggaaaaga
    11461 taaataatta ttagtataaa accttttaat atttgagaca tgctatgcat gagtgtgtaa
    11521 atttttaatc aaatattagg aggtttttta tgttgtttaa acatgtttat tagcagaata
    11581 gagtaatatt ttgtatatta agaatttaaa tataatatag tagatgatat aataaaaata
    11641 tataacattt tggggggaat agattatggt taagaaaagg ttagtagctg tagtaattag
    11701 tttagctatg attagtgtag ggaatttttc atatgctcac tcaggagggc ataattcatc
    11761 aggagatcat cataataaaa ataaatcaga gttaacacgt tattattgtg gaggacattc
    11821 agcacatcaa cacaataaag gtttttgtcc ttatgctagt acaaaagaaa attctggagt
    11881 aacaatatct tcagtacata acgaaaaaaa tcataaaaac tattttgcag aaaaagggta
    11941 taataaaggt tatgaagatg ggtgtaaagg gctttataat ttaagtgtca cagaagccaa
    12001 atctgataat ttatatgaaa aagagatttt aaaaagttca tatgaaaaag gatatttaat
    12061 tggatacaat gaatataaag caaaaaaagt agatgatgta atgaagaaga tgttagatat
    12121 tccaatgtta gcaagtatat aataatatag tatttaaaaa gatattttct ataagggaat
    12181 atctttttta ttgtaaagta taatttttcg taaaaaagta taataactga ggcgataaat
    12241 taaaataaaa cagattattt aagtagttat taatttgaga tagatacatt taatattaat
    12301 gaatctatct caataagcta agctaattta aagctaagat aaattaatat taattagcat
    12361 taaataaact ttcagaaatt ttgtcagaag cctccttatc catttcttta agtacatgag
    12421 aataaacgct tagagtagta cttatatttg agtgtcctac tctctcggat ataaccttta
    12481 taggtacttt agaatttata agtaaagtaa catgtgagtg tcttaaatca tggaatctaa
    12541 tatgaggtaa ttcattcttt tctaaaaatc ttttaaattt tttactcata acatcttcag
    12601 caataggttc acatttctta ttgaaaaaca acaaattatt attatttcta atggaagatt
    12661 ttaataaatt tttattctgt tttattttat attcttttaa taaagacatt aattctttgg
    12721 gagaagatat ttttctaaca gagctttctg tctttggctc tttgagaata acagaaccat
    12781 taattcggga agttatctta tttactgtta ttgtattttc ttcaaaatca atattatccc
    12841 aagttagacc taaaacttct gaaattctaa gacctaatcc aatagccaaa ttaataggta
    12901 attccatttc tgtatttttt gctaaatcta ataattttat catttgttct ctatcataaa
    12961 tctcattttt aaatttttta tatcttggag cctctatact atccataaca ttttctttta
    13021 ttaatttgag tctataagct ctttttattg caagtttcaa tatatttata tgaatcttaa
    13081 ttgattgagg atttagttta taagatagtt tatctatgta gttttgtatg tgaaccggat
    13141 gtaagtcttg tattttatat tttccaatag atggattaat gtaattctta caaatactaa
    13201 cataattatt atatgtagct aaagatatat tttcactata tttatttaga aaatctaata
    13261 gaaattctga cactgtaatt tcgcttggta ctaaaaaacc atcattatat aagctttctt
    13321 ttacctcatt tagtctttta cttgcttccc tttttttatc aaaagtaccc atattttttt
    13381 gttttctttt acctgttttt tcatcttcaa attccaggta aacaacatag tttttatttc
    13441 tttttctaat aaatgcattc atatataacc caccaatcaa aattttatac atttattata
    13501 acatatatat atcacaaaat aattttgaaa tagagttgca tacattttaa tacattgtat
    13561 atatttattt aaaaaatgta tatattatgt caaatattag aattttaatt tgataatctg
    13621 ttatacttat agaatagata tttatcttta tattaataga ttgtgtgttt aattttgaat
    13681 aaaaatataa attttttgta ttaataaatt tggatgagat attttaaata aaacctttga
    13741 ctcgaaaagt ctattaatat agtatttaat tatgtagaag tttgagagga gtgtaaaatc
    13801 atatgactat tactaagata ccaccagcag aattaaaagt catgaaattt atttggagtt
    13861 cagattttac agtagcatca aaagatgtca ttgaagctat ggaaaaacta tataattgga
    13921 agcaaactac aacactaaca cttttatcaa gattagtaaa taagcaattc ttaagtgcaa
    13981 gaaaaattga tagacataca cattatacag ttcttattgg agaagaagag tatttacatt
    14041 ttgaaacaaa aactttttta gataatatgc atggaagttc tattgagagt tttatgaaat
    14101 ccttgttcaa aaagggggta aatgaagaag aattgaactc tgttgaaaaa tgggttaaag
    14161 atattaaaaa agatgaataa tttggtgtag ttaattatca taaaataaat agtttttaca
    14221 ataattagtt aaatgaatca aatataaagt tttatgtaaa atttgtgatt tttataaata
    14281 tttttgtctt gttatttaat attaatacaa taagtttgat gtaaaatcaa acctgtttga
    14341 atttaattta tattgggttt gtcattaata ttattttagt ttgatattgt atacgaattt
    14401 aaaagtcaga atttttgtat attaatcatg taaattaatt gttttagata taaagggcat
    14461 aattttattt ttgttttgat tatttctagg gtaagataag t
//
LOCUS       DAEPID010000091        14241 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.091, whole genome shotgun sequence.
ACCESSION   DAEPID010000091 DAEPID010000000
VERSION     DAEPID010000091.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 14241)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 14241)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..14241
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.091"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            602..1015
                     /locus_tag="KR257_003195"
     CDS             602..1015
                     /locus_tag="KR257_003195"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898241.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0031866.1"
                     /translation="MSKSELGVKANLVSELMMLSYFFIDLLLQKFIFKGEGIWFTFII
                     LLAFWVCNLMYNKKYNDLVDEASKLMLLKVDQIASKIMLYSMFVIAVLFSVNHTRALD
                     ISNLDIGIMLLAVLFIQSLSKLILYIYFDKKGICN"
     gene            1085..1501
                     /locus_tag="KR257_003196"
     CDS             1085..1501
                     /locus_tag="KR257_003196"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003440086.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0031867.1"
                     /translation="MSKSETGVRSKLILELLVITYFFIAVLATKYIFKGPSTASLPGL
                     SWLIVFGCYSIYNKKYNDLVDESSEFILSKVNKIAIKIMIYSIVIISIFFATPYTSNI
                     NISNLDTGIILIAVLFIQSLSKLVLYIYFDKRGICN"
     gene            1502..1714
                     /locus_tag="KR257_003197"
     CDS             1502..1714
                     /locus_tag="KR257_003197"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003440076.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HBH0031868.1"
                     /translation="MAILMKTKIKEYREKLLMTQNELAKLVGVRRETIVHLENGKYNP
                     SLKLAMDIAKVFDTTVENLFEFIEEE"
     gene            2758..3591
                     /locus_tag="KR257_003198"
     CDS             2758..3591
                     /locus_tag="KR257_003198"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861844.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PRD domain-containing protein"
                     /protein_id="HBH0031869.1"
                     /translation="MVIKKVFNNNVVFARDNSGQEVILMGKGIGFNKFTKDLVEIDKI
                     EKKFIFNNEESLSELHSLLDRIPLKDVELVSEIIQMGREELGDNLNDSILITLSEHIS
                     YMLKRMDEGLVFQSPLQWEIRQIYPNEYNFSKKAVEYLRKKLDKNIPDSEIAFITIHF
                     ANAQLETKDMQETLLLTKIIDNVLDIIKYHYGIEINEYSFDYTRFISHLRCFIKRQLS
                     GENTNVDTSLLDIIKMKYKSDYNCAKKVKNFLEKTYKWKISENELLYLTLHLNRLSNI
                     K"
     gene            3717..5558
                     /locus_tag="KR257_003199"
     CDS             3717..5558
                     /locus_tag="KR257_003199"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003427382.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS glucose transporter subunit IIA"
                     /protein_id="HBH0031870.1"
                     /translation="MKFERESEEIIKYVGGKENIISLVHCATRLRFKLKDTSKTNKEE
                     LLKMKDVLSVVNSGGQYQVVIGNKVTDYFETIIKKAVLQGQNTEEQGEKVSIVSKIFE
                     SISGAFSPLIPALAGAGMIKALLTILTTMKWMSDTSSTYAILSAAGNAVFYFLPIFLG
                     ITLAIKLSANPYVGGVIGAALLDPNFTALIGAKGGANFFGMPVTAIDYSFGVFPIFVA
                     IFIYYYVDKLLKKIILKDLQLFLVPMISLLVMVPLTVILFGPIATNVGDIISNIFMGL
                     FEFNRVIAGAAIGIAMPFLAVLGLHWGFTPITLQNLATMGGDPIEGAAVAAVFAQIGI
                     AIGLFMKVRKSKKNSELKVLAGSTAVTGILAGVTEPIIYGIILRYRRMIPVLAIAGGI
                     GGGICGVFGVTCNAYVFHNIFSMPVYTPFLGYILGIGTALVLGAVLSYFFGLSKEECE
                     EGNEEVAFDEDDGIEEILSPIEGLQIELSEVEDEVFASGTIGNGMAIIPSKGEVVSPV
                     NGTITTIFPTKHAIGITSDKGVEILIHVGLNTTMLDGKYYTTHMNAGDKVKKGDRIVS
                     FDKDKIEGEGYSIVTPIILTNTNDLADVIVKENKHIKIGTPVIKVVY"
     gene            5581..7014
                     /locus_tag="KR257_003200"
     CDS             5581..7014
                     /locus_tag="KR257_003200"
                     /EC_number="3.2.1.86"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003243232.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="6-phospho-beta-glucosidase"
                     /protein_id="HBH0031871.1"
                     /translation="MKSNQEFLWGGAVAAHQVEGGYNKGGKGISIADVMTAGTHTISR
                     KITDGVIEGLNYPNHEAINFYENYKEDIRLFAEMGYKCFRTSIAWTRIFPKGDESTPN
                     EDGLKFYDDLFDELLKYNIEPVITLSHFEMPYHLVKNYGGWRNRKLIDFFVNFCEVVM
                     NRYKDKVKYWMTFNEINNQSITTNPIYAFTNSGIIYEEQEDKEEVMYQAVHYEFVASA
                     KVVKIGHEINPEFKIGCMVAAMPSYPYSCNPEDMIKFVESNREQLMFTDVHVRGHYPR
                     HTLKLWERKNYNLDITEEDKKILKEGIVDFIGCSYYLTTVVTADKTMKTTGNDSAGKA
                     DVVENPYLKISDWGWNIDPVGLRFYLNQLYDKYELPIFIVENGFGAEDVLKSDNTVDD
                     DYRIEYLASHIREMKNAIEIDGVDVIGYTVWGCIDPVSFTTGEMKKRYGFIYVDKNND
                     GSGTLKRYKKKSFDWYKNVIKFNGEIL"
     gene            7719..8597
                     /locus_tag="KR257_003201"
     CDS             7719..8597
                     /locus_tag="KR257_003201"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891502.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ketose-bisphosphate aldolase"
                     /protein_id="HBH0031872.1"
                     /translation="MLINMKEMLKVAQENQFAVPAFNIGSGQILKAVVQSANEKNAPV
                     ILAIHPNELSFLGDSFVASCIEEANKSKVPMVIHLDHGENKEQILRAIRCGFTSVMID
                     GSHLPYEENVAISREIVEIAKGLNVSVEGELGTIGTTGTSSEGGTDEIIYTDSKLAKD
                     FVEKTGVETLAIAIGTAHGIYPKGFKPELKLDLLKEIREVVDIPLVLHGGSSNPDEEI
                     AQAVKLGVCKINISSDVKSAYYKKCRELLEQNPSLYEPDTIYPPCIKSAREVIEFKMN
                     LFNAIDKLKCFYKNKN"
     gene            8633..10528
                     /locus_tag="KR257_003202"
     CDS             8633..10528
                     /locus_tag="KR257_003202"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003440068.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIA"
                     /protein_id="HBH0031873.1"
                     /translation="MIGKILRSDCIVLDKQLQTKKDVINYMANHLYHGNYINNKEKFI
                     ADINKREKESSTNMGNLIAIPHAKSNVVNQPVMMYLRTDREITDNDGQKLRSFFMIAV
                     PESGSDEHLKIISKLATYLMEENFLKHLLSAETPYEILSIFNNKAAESGDFSNNQNKG
                     LIVGITGCPTGIAHTFMAKKALEEAGQELGYEVKIETHGAIGVENKLTKEDIKRAEYV
                     IIACDKEVQLSRFIGKKVLQKKVVDAKNVSLAKNLIINAENGMAKEIKPGGKTLEDSK
                     EMLQGSEKKGVYKHLMSGVSEMIPFVVIGGIGIAIAFMFGIFASDPTHETYNPIAGFF
                     GQLGGDSAFKLFIPILAGFIAKSIAGRQGFAPAMIAGFMAVIGGSGFIGGMVAGFATG
                     YIALGVMKITENLPDVLKGVNAVLICPLLIAFTSGAIMFFVVNTPASWLNEALQSWLQ
                     SMSGTNKVLLGAILAGMMASDMGGPINKTASAFGLAMFSSNIFEPSAALMVGGMVPPL
                     AISLAMLIFKNKFTKEERKSSLPTAIMGASFITEGAIPFAAADPLRMIPANIIGSCIG
                     GAICMSLDITLMAPHGGIFVIPFACSAPVAYIACILIGTVITALIIGVTKPTIRSENS
                     EVELLGA"
     gene            10796..12703
                     /locus_tag="KR257_003203"
     CDS             10796..12703
                     /locus_tag="KR257_003203"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898236.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcription antiterminator"
                     /protein_id="HBH0031874.1"
                     /translation="MLVSRQIEFLKLILNENKYRPIKYFKDKLNVSDKTLQKDLKMIE
                     KYLETFNIKIDIKRGYGILIEDLAKKNIDLINSLNIQSKENKSLSVEQRRMEILKYLL
                     LNSNNITSINQLADKYYVSKTSIVNDFKYIEAWIKEYNLKLNKTLEGTKIIGKEVDIR
                     KSIAKMMDDLLDENYEQHDISELTRLDSATFSALINLFDIDSIIFVETIITELEYNLG
                     YTINQPYYINLITHILICLKRIEEGNQIESQEEREISVDNLDELVYKNVSTLIDKIEN
                     RYRVKITKDEIMYIYIFLVSSGFSSENNSSYNDESDRLSESEKVSSIMIENMSRFLNI
                     NLKNDDLLQKSLASHVRPMLNRLRYDIQIKNPLLGEIQERFSDVLGLCMMTINIMTEY
                     DNLKNISIDEVSYLATYFQAAIERNMSSKRVIVVCHTGYGTSQLLAARLKREFPEWTI
                     VDIVPMHQLSKRNLDDVDFVISTVNLDLKDKLHIVVSVLLMENDINNIKNALLSKPKK
                     SMNLDTNLLGMYLEDNIYFNFDVAQMESLIGVNLGSKYESISLGKDLNIYIHKQSKLN
                     KGIMNINNVTRTIDIYLEISNQSFLKNILMEISNLYRQKNYINYIIDCKSKEDIKILF
                     KNNLLEKTNGN"
     gene            12693..13142
                     /locus_tag="KR257_003204"
     CDS             12693..13142
                     /locus_tag="KR257_003204"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728825.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIA"
                     /protein_id="HBH0031875.1"
                     /translation="MEIREILTEESIILDLKSTTKEGIIQELVDKLYDTGSITLKSKF
                     IKALKHREKIGSTSIGYQMAMPHGKTKYVKKASIVIGKSKKGVDWPSIDGLPVKVIIM
                     FAMPQSGGNEDMILISKIAYILGGKNIGERLLNANTKKEILDIFYEV"
     gene            13242..14129
                     /locus_tag="KR257_003205"
     CDS             13242..14129
                     /locus_tag="KR257_003205"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898235.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AraC family transcriptional regulator"
                     /protein_id="HBH0031876.1"
                     /translation="MAIYLEMPKLIHEFPFRSLSNEGEVLTTPHWHKEIEILLITEGV
                     VNLFINDKPMQLKKGEIVIIKGGDIHYILPSPGSERLVFQFDISFFNDLILLNEEKES
                     LINLFSSIKKCSRDWSAKIRKSVFDILIDIYNEDLYKIEGYSYAIKGKMYNLIPILYR
                     QIPREIEENTVEYEINSKEILERLNNIFKYVEKNYKQPIKLEDVSYEVGFSVYYFTKF
                     FKKNTGKTFITFLNEYRLEKAKWILLNNNISIVDLVEEVGFGSTKTFYRVFKEKIGVS
                     PLEFKKRYNSLEKKGSVSK"
BASE COUNT         5677 a         1414 c         2495 g         4655 t
ORIGIN      
        1 cctataataa aatttatcat tagttacata tagaataaac ctcagttttg attactgtag
       61 gaactaggat tatatgaagc taccactcat agatttcagt tttttctgtt gtatcatagc
      121 atagaatagt aaattcatct gaaactttat tttaaattta gaatttgcat atagataaat
      181 tatgggcatt attctgatga ttcgtctcca ataattaaaa aaagaatgat aaaatacttg
      241 aaaatactag tctttattga ctagtgtttt tttatttcag tgataaaata taccaattat
      301 acttcagtta caggaaatga tgtttttgag ggtacattgg gaggcattta ggttgtataa
      361 ttataaattt caatgttata tgctcattag aataatagtt agtaaatgat atgattgaga
      421 tgatagatga aataaactaa tttagtactg tattgtaatg tttattataa aatcttttat
      481 aaaatatatt tatgaagata ttattgaata ttttcaatat tctattgcaa tttatttgga
      541 aaagttatat atttataaca taaggtgtta taaatatata acttttaagg ggtgatttta
      601 tatgtctaaa tcagagcttg gtgttaaggc aaatcttgtt tcagagttaa tgatgctatc
      661 ctattttttt atagacttgt tattacaaaa gtttattttt aaaggagaag gtatttggtt
      721 tacttttata attttattag ctttttgggt gtgcaatctc atgtataata aaaaatataa
      781 tgatttagtt gatgaggcat caaaacttat gttgttaaag gttgatcaga ttgcatcaaa
      841 aataatgtta tactctatgt ttgtaatagc tgttctcttt tcagttaatc atacaagagc
      901 tttggacata tcaaatttgg atataggtat aatgctctta gcagttttat tcatacaatc
      961 tttgtcaaaa ttaattttgt atatatattt tgataaaaag ggaatatgta actaagtaat
     1021 aatatttatg aaaacaaaaa ttaaaaaata tagagaatat ataactttta aggagtgatt
     1081 ttatatgtct aaatcagaaa ctggtgtaag atcaaagctc atcttggaat tacttgtaat
     1141 aacttatttt tttatagctg tattagctac taaatatatt tttaaaggtc caagcactgc
     1201 ttctcttcca gggttgagtt ggttaatagt ttttggatgt tattcaattt ataataaaaa
     1261 atataatgat ttagttgatg aatcatctga atttatacta tcaaaggtta ataagattgc
     1321 aataaaaata atgatatatt ctatagtaat aatatctatt ttctttgcaa caccttatac
     1381 aagtaatata aatatatcaa acctagatac aggtataatc ctcattgcag ttttatttat
     1441 acagtcttta tctaaattag tgttgtatat atactttgat aaaaggggga tatgtaacta
     1501 agtggcaata ttgatgaaaa caaaaattaa agaatacaga gaaaaactcc ttatgacgca
     1561 aaatgaactt gctaaattgg ttggggtaag acgtgagact attgtacact tagaaaatgg
     1621 gaaatataat ccttctttga agttagctat ggatatcgct aaagtattcg atactacagt
     1681 agaaaatttg tttgaattta ttgaagaaga atagtggaaa gtttataaac atttataaga
     1741 tggataatga aatatagtta tttaattatt aagtttatta aaaatattta tataatatgt
     1801 gattaaggtt agattataat tgttttaaga taataagaag agtattataa atgataaaaa
     1861 atagtgaata tacagttaat taataaacaa tagataaaaa tttaaagttt aaatgtaaag
     1921 aggatgtata attttatgaa atctaataag acactgttat aatcgctatg taaggaaatc
     1981 atattagaat tttctaagaa aacagttaag aatttggaag taagtatgtg ttatttatat
     2041 acttctgaaa catataaact aataagtgag gttgtatcag atatgtcttg taagggtaat
     2101 ttcttcaggt tcatcaacta tcataactct acagagggta taagatatgc tttgtaaggg
     2161 taatatatgc ttgattcaag aattagtgtt ataaaatgga ttagcatacc aaaaggtcta
     2221 ttaaagatat acagttaaaa agctatatag taagttaggt aaggttaata atccaaacaa
     2281 tgatttgatg attaaactgt ttagagcctt agatacaaca gtaaaagaat tattttttaa
     2341 taaggagaag taaaagataa aagaaaatca aaacttaggc agttattgta gttacaaaat
     2401 aaaggatttc cttatatatg gataaataat cgagtatata taataaaaaa tatatgacct
     2461 taattttgtt atgaaataac ttcaaaactt attttagcat gtttagatta tataaatcat
     2521 ataaaaaaag tagaatgagt gaatacttat gacaataatc tagtagagat atacatgaaa
     2581 ttatatattg actaagtaca gttattattt tataatgaaa ataaagttat catacagata
     2641 aataaacgga tcgttactga gatagatgta atcaggcgtg acctaaaaat tctagtaaat
     2701 gcttaaagta ttattagtct tttttaggtc tctttttgtt tacagtggag gtagtttatg
     2761 gttataaaga aagtatttaa taataatgtt gtatttgcca gagataattc aggacaagaa
     2821 gtaatattaa tgggaaaagg aattggattt aataaattta ctaaagattt agttgaaata
     2881 gataaaattg aaaagaaatt tatattcaat aatgaggaat cattaagtga attacattca
     2941 ctactagata ggataccttt aaaagatgtt gagcttgtaa gtgaaattat tcaaatggga
     3001 agagaagaat tgggtgataa tcttaatgat agtatattaa tcacattatc agaacatata
     3061 agttatatgt taaaaagaat ggatgaagga ttagtatttc aaagcccgct tcaatgggaa
     3121 ataagacaaa tatatcctaa tgaatataat tttagtaaga aagctgtaga atatttaaga
     3181 aaaaaattag ataaaaatat tcctgattct gaaatagcat ttattacgat acactttgca
     3241 aatgctcagt tagaaacaaa agatatgcaa gaaactttat tgttaactaa gataattgat
     3301 aatgtattag atatcataaa gtatcactat ggaatcgaaa taaatgaata ttcctttgac
     3361 tacacaaggt ttataagtca tttaagatgt tttataaaaa ggcaattaag tggtgagaat
     3421 acaaatgtag acacatcatt gttagatata ataaaaatga aatataaaag tgattacaat
     3481 tgtgcaaaaa aagtaaaaaa ctttcttgaa aagacgtata aatggaaaat tagcgaaaat
     3541 gaattgttgt acttaacatt gcatttaaat agattatcaa atataaagta aatagtgtag
     3601 gattgttact gtttggcagg catgacctaa gttggtataa ttagttttta atatctaatt
     3661 gtattgattt aggtctattt ttatacataa aattatgaaa atggaggata gattgtatga
     3721 aatttgaaag agagtctgaa gaaattataa aatatgtcgg aggaaaagaa aatattatta
     3781 gtttagttca ttgtgcaact aggctacgtt ttaagctgaa agatacttca aaaactaaca
     3841 aagaagagtt attaaaaatg aaggatgtac tatctgtagt aaatagtgga ggacaatacc
     3901 aagtggtaat tggaaataaa gtaactgatt actttgaaac tattataaaa aaagcagttt
     3961 tacaaggaca aaatactgaa gaacagggag aaaaagtttc aatagtttct aaaatatttg
     4021 aatcaatttc aggtgcattt tctccattaa tacctgcact agctggagca ggaatgatta
     4081 aggcactgct tacaatacta actactatga aatggatgtc tgatacaagt agcacttatg
     4141 ctatattatc agcagctgga aatgctgtat tttacttttt accaatattc ttaggtatta
     4201 ccttagctat aaaacttagt gcaaatccat atgttggtgg agtgatagga gcagctttgt
     4261 tagatcctaa ttttacagct ttaattggag caaaaggtgg tgctaacttt tttgggatgc
     4321 cagtaacagc aattgattat tcttttggtg tattccctat atttgttgct atatttattt
     4381 attactatgt tgataagctt ttaaagaaga ttatattaaa ggatttacaa ttattcttag
     4441 taccgatgat atcattatta gtcatggttc ctttaactgt gattttattt ggaccaatag
     4501 caactaatgt tggtgatata atatctaata tttttatggg attatttgaa tttaacagag
     4561 taattgcagg agctgcaata ggtatagcta tgccattctt agcagtatta ggactacact
     4621 ggggcttcac accaattact ttgcaaaact tggctacaat gggtggagac ccaatagaag
     4681 gtgcagctgt tgcagcagta tttgctcaaa taggtattgc aataggttta tttatgaagg
     4741 ttagaaaatc taaaaaaaat tcagaattaa aggtattagc aggttcaaca gcagttacag
     4801 gaattttagc aggagtaaca gaacctataa tttatggaat tatattaaga tacagaagaa
     4861 tgattccagt attggctatt gcaggaggta ttggtggtgg tatatgtggt gtatttggtg
     4921 ttacttgtaa tgcatatgta tttcataata tattctcaat gccagtttat acaccattcc
     4981 taggatatat attaggaata ggaacagcat tagtgctagg agcagtattg tcatatttct
     5041 ttggattgag taaagaagaa tgtgaagaag gtaatgaaga agttgctttt gatgaagatg
     5101 atggtataga ggagatatta tctccaatag aaggcttaca aatagagtta tctgaagtag
     5161 aagatgaagt gtttgcatca ggaactatag gtaatggcat ggcaataata ccttcaaagg
     5221 gagaagttgt gtctcctgta aatggaacaa taacaactat ttttcctaca aagcatgcaa
     5281 taggaattac ctctgataaa ggtgtagaaa tattaataca cgtaggtctt aacactacta
     5341 tgttagatgg aaagtattat actactcata tgaatgcagg agataaagtt aaaaaaggag
     5401 ataggattgt ttctttcgat aaggataaaa tagaaggtga agggtatagt attgttacac
     5461 caataatact aactaacaca aatgatttag cagatgtaat agttaaagaa aataaacata
     5521 ttaaaattgg aacgcctgta ataaaagttg tttattaatt atactggagg agatatttct
     5581 atgaaatcta atcaagaatt tttatgggga ggggcagttg ctgcccatca agttgaaggt
     5641 ggatataata aaggtggaaa aggaataagt attgcagatg tgatgactgc aggtactcat
     5701 actatttcaa gaaagataac agatggagta attgagggtt taaattatcc taatcatgaa
     5761 gccattaatt tttatgaaaa ttataaagaa gatattagat tatttgctga aatgggatat
     5821 aagtgtttta ggacaagtat tgcttggact agaatttttc caaagggcga tgaatcaact
     5881 ccaaatgaag atggattgaa attttatgat gatttatttg atgaattatt aaaatacaat
     5941 atagagccag taataacttt aagtcatttt gaaatgcctt atcatttagt aaaaaactat
     6001 ggtggatgga gaaatagaaa attaatagat ttctttgtaa acttctgtga agtggtaatg
     6061 aatagataca aggataaagt taagtactgg atgactttca atgaaataaa taatcaaagt
     6121 ataactacaa atcctattta tgcatttact aactcgggaa taatctatga agagcaggaa
     6181 gacaaagaag aagttatgta tcaagcagtt cattatgaat ttgtagcaag tgcaaaggtt
     6241 gtgaagatag gtcatgaaat aaaccctgag tttaaaattg gatgtatggt ggcagctatg
     6301 ccaagttatc cttattcttg caatccagag gatatgatta aatttgtaga atctaataga
     6361 gaacaactta tgtttactga tgtacatgta agaggtcatt atccaagaca tacactaaaa
     6421 ttatgggaaa gaaaaaatta taatttagat attacagagg aagataaaaa aatcctaaaa
     6481 gaaggaatag ttgattttat tggatgtagt tattatttaa ctactgtagt aacagctgat
     6541 aaaactatga aaacaacagg taatgactcg gcaggaaagg ctgatgtagt tgaaaatcca
     6601 tacttaaaaa tttctgattg gggatggaat atagaccctg taggtctaag gttttacctt
     6661 aatcaactat atgataagta tgaacttcct atattcattg ttgaaaatgg atttggagca
     6721 gaagatgtat taaaatcaga taatactgta gatgatgatt atagaataga gtatttggct
     6781 agtcatataa gggaaatgaa aaatgccatt gaaattgatg gtgttgatgt tatagggtat
     6841 actgtttggg gatgtataga tccagtatca tttacaacag gagagatgaa aaaaagatat
     6901 ggatttatat atgtagataa aaataatgat ggaagtggga ctcttaaaag atataaaaag
     6961 aaatcttttg attggtataa aaatgtaata aaatttaatg gagaaatttt ataggtagat
     7021 aaattttaat atttataaga ttatgttaag gaaaccatta aaaattagat taaaatcgtg
     7081 ggtatttaaa tccactaaaa gatattgact atttagtcaa tatctttttt tattaaaaag
     7141 taaatataaa gaggtaaggt taaaaattgg gatatatatg atttatatag tatgatttaa
     7201 ttagaaggag ctatattagt attcatttgt atagttggag aataaatgtc agtcttacct
     7261 tacgattttt ataatagtcc tatttaattt ctattgtaac taatatgcaa gaatttaaga
     7321 tagaagtatc tatgacttat ggtgtattaa taattggtat ctgctatcta gtatcttttt
     7381 aatttttttg attccaatat agtgctaact acgatacgaa tatctttaaa tttatagcta
     7441 aactatctaa ttgtttattg gaaagagtta agaaggctaa agcataaaac acttaaaaag
     7501 agaagatgta tatgagaaat ataattaact atgatgcaga cttctaaaaa ttatttagtg
     7561 aaaaggaact tagagtgtat aataaaagtt ccttttcact aaggaaaacg attgttattt
     7621 tctgatcttc attaccctga tattatttaa atataaacaa caacaaaatt aacaagaagc
     7681 aaattcaacc taaaatttaa aatatcggga ggtacaatat gttaataaat atgaaggaaa
     7741 tgctaaaagt ggcacaagaa aatcaatttg ctgtaccagc atttaatata ggaagtgggc
     7801 aaatacttaa agcagtagta cagagtgcta acgaaaaaaa tgcaccagta atacttgcaa
     7861 tacacccaaa tgagctaagt tttctaggag atagctttgt agctagttgc atagaagaag
     7921 caaataagag taaagtacct atggtaatac acttagatca tggggaaaat aaagaacaaa
     7981 tattaagggc aataagatgt ggatttacat cagtaatgat tgatggctca catttaccat
     8041 atgaagagaa tgtagctata tctagggaaa tagtagaaat agcaaaagga ttaaatgtgt
     8101 ccgtagaagg agaacttgga acaataggaa caacaggaac atcaagtgaa ggtggtactg
     8161 atgaaataat atatacagat tcaaaattag ctaaggattt tgttgaaaaa acaggagtag
     8221 aaacactagc tattgcaatt ggtacagcac atggtatata tccaaaaggt tttaaaccag
     8281 agcttaaact agatttatta aaagaaataa gagaagtagt agatatacct ttagttcttc
     8341 atggtggttc atcaaatcca gatgaagaaa tagcacaagc agttaaacta ggagtttgta
     8401 aaataaatat ttcgagtgat gttaagtcgg catattataa gaagtgcaga gaactattag
     8461 aacaaaaccc aagcttatat gagccagata ctatatatcc accatgtata aaatctgcaa
     8521 gagaagttat agagtttaaa atgaatctat tcaatgctat agataagtta aagtgctttt
     8581 ataaaaataa aaattaatta tgaggtaaca aattaaaagg aggggagaat ttatgatagg
     8641 taaaatacta cgaagcgatt gtattgtact agataaacaa ttacaaacaa aaaaagatgt
     8701 aattaattat atggcaaatc atttgtacca tggaaattat ataaataata aagaaaagtt
     8761 tatagctgat attaataaac gcgaaaaaga atcatcaact aatatgggta atttaatagc
     8821 tatacctcat gctaagtcaa atgtagtaaa tcaacctgta atgatgtatt taagaacaga
     8881 tagagagatt acagataatg atggtcaaaa acttaggtca ttttttatga tagcagttcc
     8941 agaatcaggt tcagatgaac atcttaagat tatatctaaa ctagctacat atctaatgga
     9001 agaaaatttt cttaagcatc tactaagtgc agaaactcca tacgaaatat taagtatatt
     9061 taataataaa gctgcagaat caggagattt tagtaataat caaaataaag gtcttatagt
     9121 tgggataaca ggatgtccaa caggtatagc tcatactttt atggcaaaaa aagcattaga
     9181 ggaagcaggt caagaacttg gatatgaagt taaaatagaa actcatggag ctataggtgt
     9241 agaaaataag ttgactaaag aagatataaa aagagctgaa tacgtaataa tagcttgtga
     9301 taaagaagtt caactgagta gatttatagg aaagaaagtg ctacaaaaga aagtagtaga
     9361 tgctaagaat gtttcattag ctaaaaattt aattataaac gctgaaaatg gaatggctaa
     9421 agaaattaaa ccaggtggaa agactttaga agattcaaaa gaaatgcttc aagggtcaga
     9481 gaaaaagggt gtttataagc acttaatgag tggtgtatct gaaatgattc catttgtagt
     9541 gataggtgga attggtatag ccatagcttt tatgtttggt atatttgcat cagacccaac
     9601 tcatgaaaca tacaacccta tagctggatt ctttggacaa cttggaggcg attcagcatt
     9661 taagttattt ataccgatac ttgctggttt tatagctaaa tcaatagcag gaagacaagg
     9721 atttgctcct gctatgatag ctggttttat ggcagttatt ggaggttcag gttttatagg
     9781 tggtatggta gctggttttg caacaggata tatagcttta ggagtaatga agataacaga
     9841 aaatttacca gatgtattaa aaggagtaaa tgctgtattg atatgtccac ttttgattgc
     9901 atttacgagt ggagctataa tgttctttgt agttaatacg ccagcatcat ggttaaatga
     9961 agctttacaa tcttggttac aaagtatgtc tggaactaat aaagtattat taggtgcaat
    10021 attagcaggg atgatggcat cagatatggg aggacctatt aataaaacag cttcagcttt
    10081 tggattggct atgttttcaa gtaatatatt tgaaccatca gcagcattaa tggtaggagg
    10141 aatggtacct ccattagcaa tatcattagc tatgttaata ttcaaaaata agtttactaa
    10201 agaagaaaga aagtcatctc taccaactgc tataatgggg gcatctttca taacagaagg
    10261 cgcaataccg tttgcagctg cagacccatt aagaatgatt ccagcaaata taattggttc
    10321 ttgtataggt ggggcaatat gtatgagttt agatataact ttaatggcac cacatggggg
    10381 aatatttgta ataccatttg catgtagtgc accagttgca tatatagctt gtatattgat
    10441 tggtacagta ataacagcat tgattatagg ggtaacaaag cctactataa ggagtgaaaa
    10501 tagtgaagtt gaattacttg gtgcttaaat tataaataat agtaaaaata attaatggaa
    10561 taacaacaag tatatagaat aataataagg atatttagaa tcagttaact acttctaaat
    10621 atccttaatt tttattttga aattatatta tctattatat caatttagta aggtgtatca
    10681 taaattcttt tatgatacag aagtatctta gtaattttac atagttagta aatatgttaa
    10741 aatagtactt aatataaaca tagaaatata taaacatagg tagggagggc taagtatgct
    10801 tgtgtcgagg caaattgaat ttcttaaatt gatactaaac gaaaataaat atagacctat
    10861 aaaatacttt aaagataaat taaatgtatc tgataaaact ttacaaaaag atttgaagat
    10921 gattgagaaa tatttagaaa cttttaatat aaaaattgat ataaaaagag gctatggaat
    10981 attaatagaa gatttagcaa agaagaatat agacttaatt aatagtttaa atatacaatc
    11041 gaaggaaaat aaatctttat cagtagagca gagaagaatg gagattttaa agtatttatt
    11101 actaaattca aataatataa cttcaataaa tcagttagca gataaatatt atgtaagtaa
    11161 aacttctata gtaaatgatt ttaaatatat agaggcatgg ataaaagaat acaatttaaa
    11221 acttaataaa actttagaag gaactaagat tataggtaaa gaagtggata taaggaaatc
    11281 gattgccaaa atgatggatg atttattaga tgaaaattat gaacaacatg atatatctga
    11341 gttaacaaga ttagattctg ctacatttag tgcattgata aatttatttg atattgattc
    11401 tattatattt gtagaaacta taattacaga attagaatac aatttaggat atactataaa
    11461 tcagccctac tatataaatt taattaccca tatacttata tgtttaaaga gaatcgaaga
    11521 aggtaatcaa atagaatctc aggaagaaag agaaatttct gtagataatt tggacgagtt
    11581 agtatataaa aatgtcagta cacttataga taaaatagaa aatagataca gagtaaaaat
    11641 aacgaaagat gaaattatgt acatatatat ttttttggta tcatctggat ttagtagcga
    11701 aaataatagt agttacaatg atgaatcaga tagattaagt gaaagtgaaa aagtttcatc
    11761 tataatgata gagaatatgt cacgattttt aaatataaat ctcaaaaatg atgacttact
    11821 acagaaaagt ctagcatctc atgtaaggcc tatgttaaac agattaagat atgatatcca
    11881 aataaaaaac ccgttgttag gagagataca agagcgattt tcagatgtgc tgggattatg
    11941 tatgatgact ataaatatta tgacagagta tgataatctg aagaatatta gtatagatga
    12001 agtttcgtat cttgccacat attttcaagc ggcaatagaa agaaatatga gtagtaaaag
    12061 agtaatagta gtttgtcata caggatatgg aacatctcag ctccttgcag ccagattaaa
    12121 aagagaattt cctgaatgga ctatagttga tatagttcct atgcatcagt tgagtaagcg
    12181 aaatttagat gatgtagact ttgtaatatc tactgtaaac ttagatttga aagataaatt
    12241 acatatagtt gtatcagtac tattaatgga aaatgatatt aataatataa aaaatgcttt
    12301 actttctaaa cctaaaaaaa gtatgaactt agatacaaac ttattaggaa tgtatttaga
    12361 agataatata tattttaatt ttgatgtagc tcagatggaa agtttaatag gtgtgaattt
    12421 agggagtaaa tatgaatcta tttcattagg aaaagattta aatatatata tacataagca
    12481 aagtaaatta aataaaggga taatgaatat caataatgtt actagaacga ttgatattta
    12541 tttagaaatt agtaatcaaa gttttttaaa gaatatttta atggaaatat caaatttata
    12601 taggcaaaag aactatataa actatataat agattgcaag agcaaagagg atattaaaat
    12661 attatttaag aataatctat tggagaaaac aaatggaaat tagagaaata ttaacagaag
    12721 aaagcattat tttagatttg aaatcaacta caaaagaagg cataatacag gaattagtag
    12781 ataaattata cgatacagga agtataactt taaaaagtaa gtttataaag gcattaaaac
    12841 atagagaaaa aataggctct actagcatag gttatcaaat ggccatgcca catggaaaaa
    12901 caaaatatgt aaagaaggca tccatagtaa taggtaaatc taaaaaaggt gtagattggc
    12961 caagtataga tggcttacct gtaaaggtaa taattatgtt tgctatgcca caatctggag
    13021 gcaatgaaga tatgatatta atatctaaaa tagcttacat tttaggtggt aaaaatatag
    13081 gtgaaagact tttaaatgca aatacaaaaa aagaaatatt agatatattt tatgaagtgt
    13141 aggtattgta taaattataa atttgaggtt tttaaaataa aatgtgtatt cttttaaata
    13201 gtataaatta atttttagac actagagagg agaggatata tatggcaata tatttagaaa
    13261 tgcctaaatt aatacatgaa tttccttttc gtagtctatc aaatgaagga gaagtattaa
    13321 caacaccaca ctggcataag gaaatagaaa tattacttat aacagaaggt gtagtaaatc
    13381 tatttataaa tgacaagcct atgcaattaa aaaaaggcga gatagtgata ataaaaggag
    13441 gagatattca ttatatactg ccatcaccgg gaagtgaaag attagtattt caatttgata
    13501 tatctttttt taatgattta attttattaa atgaggaaaa agaaagctta attaatttat
    13561 tcagtagtat aaaaaaatgt agtagagatt ggtcagcaaa aataagaaag tcagttttcg
    13621 atatattgat agatatctac aatgaagacc tatacaaaat agaaggatat agttatgcaa
    13681 taaaaggtaa aatgtataat ttaattccta tattatatag acagattcct agagaaattg
    13741 aagaaaatac agtagaatat gaaataaact ctaaagagat attagagaga ttgaacaata
    13801 tattcaaata tgtagaaaaa aattataaac aacctataaa attagaagat gtgtcttatg
    13861 aagtaggatt tagtgtatat tattttacta aatttttcaa aaaaaataca ggaaaaacat
    13921 ttataacttt tttaaatgaa tatagattag aaaaagcaaa gtggatatta cttaataaca
    13981 atatatccat tgtagatttg gttgaagaag ttggttttgg aagtacaaaa actttttaca
    14041 gagtatttaa agaaaaaatt ggagtctctc cattagaatt taaaaaaaga tataatagct
    14101 tggaaaaaaa agggagtgtc tcaaaatgaa cttagttcat gaggcacttt cttttatatg
    14161 aaatcaaata tattttcagt atttcaacaa tgaaaattcc attcatttat aaagtctaaa
    14221 ttttagttct caatacaacc t
//
LOCUS       DAEPID010000092        14222 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.092, whole genome shotgun sequence.
ACCESSION   DAEPID010000092 DAEPID010000000
VERSION     DAEPID010000092.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 14222)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 14222)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..14222
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.092"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     regulatory      complement(115..198)
                     /regulatory_class="riboswitch"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF01786"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="cyclic di-GMP riboswitch class II; Derived by
                     automated computational analysis using gene prediction
                     method: cmsearch."
                     /bound_moiety="cyclic di-GMP"
                     /db_xref="RFAM:RF01786"
     gene            complement(431..1273)
                     /locus_tag="KR257_003206"
     CDS             complement(431..1273)
                     /locus_tag="KR257_003206"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893923.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphate ABC transporter substrate-binding
                     protein"
                     /protein_id="HBH0031877.1"
                     /translation="MFKKKIGVLLASTMLVGALAVGCSSNSGGSGDSGDSSKVSVSGS
                     TSIGPLMETIGEKFQEKNQGVSVEVQQIGSSGGIKNAIEGTSEIGMSSRDLKDEEKSA
                     GLKETKIAIDGIALITNTANSVKNLTMDQVKGIYTGKITNWKEVGGNDAPIVIVSREE
                     GSGTRDGFQEIVGFDSEELTKDAQISDGSGNIKTTVEGNENAIGYISFGYVDEKVNSL
                     KINDVEATDANVIANKYPISRPFILVNKEDGLSEKGKALIDYILSDEGQALVSEKGFI
                     KVNQ"
     gene            complement(1525..3309)
                     /gene="pepF"
                     /locus_tag="KR257_003207"
     CDS             complement(1525..3309)
                     /gene="pepF"
                     /locus_tag="KR257_003207"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004453998.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="oligoendopeptidase F"
                     /protein_id="HBH0031878.1"
                     /translation="MGTDRSTIEEKYKWKIDKMYSSKEEIEKDISKVKNLIQEVKEYK
                     GKLSESKENLYKVLNISENASRIVQNLYVYTHMKQHEDTRINDNQGRATKTEMLSTDL
                     GVATSYIVPEILAIEENKLSEYLKDEKLSFYTKYIKDILRDKPHTLSEREEEILAATS
                     ELSTIPENVYDMLAYADMEFPEIEDEEGNKVKLSHSNYSLFIKSKNSRVRKDAFEGEF
                     STYEKYKNTFASTLYGGIKSEIFYAKTRKYNSAIEASLFSDDVSLDVYNNLISAIDKS
                     IPNLNKYVELKKKFLGLNEIHMYDLYVPLTDKFDMDIPYDKAQDIILEALKPLGEEYL
                     KVIKSAFDEGWIDVYDNEGKKGGAYSWGSYDSHPYILMSYKNDLNSLFTLVHELGHSV
                     HSHYSRTSQPFLYSDYKIFVAEVASTLNELLLINYLLENSKSKDETIYLLNYYLEQFR
                     TTVHRQTMFAEFEKIVHQRVESGEPLTADEFTNIYYKLNEKYYGKSAIVDKQIGIEWA
                     RIPHFYSNFYVYKYATGFSAASALSQQILSEGSTAVDRYINFLKSGGSEYPLEQLKSA
                     GVDMTKKESIEEALNVFAELVNKLEKEL"
     gene            complement(3375..4040)
                     /locus_tag="KR257_003208"
     CDS             complement(3375..4040)
                     /locus_tag="KR257_003208"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003417197.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MgtC/SapB family protein"
                     /protein_id="HBH0031879.1"
                     /translation="MIDIGSKEIAIRLLLALIIGGIIGLEREKIRQFAGFRTHILIAI
                     GSCIVSITSIQLFFDYNLYTNADPARMPAQVLSGIGFLGAGAILKNKGGVKGLTTAAG
                     MWATACIGIAVGYGYYELAILGGLFVMIALFVLRIINTFLFSQEKNVLILKLSNLDSI
                     PFLYDKFEKNQLIVRNMEIECRNEEYWKVNFFVSYAKRIHLHDVMKEINMIEGVINVD
                     YLD"
     gene            complement(4191..4352)
                     /locus_tag="KR257_003209"
     CDS             complement(4191..4352)
                     /locus_tag="KR257_003209"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891746.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aspartyl-phosphate phosphatase Spo0E family
                     protein"
                     /protein_id="HBH0031880.1"
                     /translation="MANNELEALKNEIEAVREEINTYIEYPEIFQEELVESSKKIDIL
                     INKYMYLSK"
     gene            complement(4430..4939)
                     /locus_tag="KR257_003210"
     CDS             complement(4430..4939)
                     /locus_tag="KR257_003210"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003417195.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Gx transporter family protein"
                     /protein_id="HBH0031881.1"
                     /translation="MKTRKMTFLGLMIGYSLALYVLETYIPNPLIVIFPGAKLGLSNI
                     ITLISLMLLGVKDTVIIVTIRVILSSIFAGPLSYLLFSIGGAYLSLLFMYLASKIKDL
                     SLIGISIIGAIGHNIGQLIVASLIIENILAIGYLPFMLMASLVTGMFVGLVSRYTIPK
                     LKHFYSKFY"
     gene            5145..5363
                     /locus_tag="KR257_003211"
     CDS             5145..5363
                     /locus_tag="KR257_003211"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003417194.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ferrous iron transport protein A"
                     /protein_id="HBH0031882.1"
                     /translation="MTVYDLKIGEKGFINSIDGDIKLSKRLLALGCINSTEIEVKKVA
                     PLGDPIIIRFRGFDLAIRKSDAKNISLQ"
     gene            5381..7327
                     /gene="feoB"
                     /locus_tag="KR257_003212"
     CDS             5381..7327
                     /gene="feoB"
                     /locus_tag="KR257_003212"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003432373.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ferrous iron transport protein B"
                     /protein_id="HBH0031883.1"
                     /translation="MINVALLGNPNVGKTTVFNLLTGSNQYVGNWPGVTIEKKEGFLG
                     KEIKVVDLPGIYAMDTFSNEEKVSKSYLENEDVDVIVNVVDASNLSRNLYLTTQLMQF
                     NKPIVILLNMLDIAESKGVNIDAKKLSEELGVIVVPIIAKKKNGVDRIEEEIKGATQK
                     AFIYQKNFGSETETYKKLESILSRCTKTTYTQKKSISDKIDNIVLNPILAYPIFIGVL
                     FLLFKFTFDWVGGPLQEGFASLIEAYISAPVSDMLSNSSPWFKSLIVDGIIGGVGGTL
                     PFFPLIFTLFFGISLFEDSGYMSRTAFLMDKVMRKVGLSGKAFIPIVMGMGCSSPAIM
                     ATRTLESEKDRRVTALIAPLMTCGAKLPIYALFVAIFFPHNAALVTTSLYLVGIVMAI
                     VVALFLNKTAFKTEAEPFILELPEYRIPTIDALIKNTWNKSKGFLIRVVTVMFAMSVV
                     IWGLSSFNVFGYTEDINVSFLATLGHIISPIFKPLGFDDWRTSVAILSGLGAKEIVVN
                     SLNILYGNLTVVLPTIFNGVTAYTFLIFTALYTPCIAALATMKKEYGNKMMFTSFAYQ
                     FILAWIMAFIVKSIGGVLFMGNSIMEALIGGIIIVLALFILFNKFKSTKNGNVCSGCS
                     ICSGCPSANSCSSKEDSNKKNNAH"
     gene            complement(7506..8561)
                     /locus_tag="KR257_003213"
     CDS             complement(7506..8561)
                     /locus_tag="KR257_003213"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891749.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SIS domain-containing protein"
                     /protein_id="HBH0031884.1"
                     /translation="MTIQDYMLETPVRMREIISNADSLFNEVKRTNLKKIIITGSGTS
                     YHSGVQVQPYLQNLLDIDVVKMYPFMITEDTFKFDNENTLVVGVSQGGSSYSTYNAMK
                     LAEDKGCKIASMAGCKNALIDEISDYILTVNCGEEKSGAKTKGYYCTKLNLMLLGLQI
                     AREKGIISSEKYNEEINKILDAINRFEAVYKLSKQWIERNKEKLVNSKEIRIIGHSDI
                     YGDTLEAALKLLETMRIPVTGYEFEEFIHGIYNAINSDSTIFILDTGKEPRVTKMIDV
                     LSGWTENVFAIGRDVTENDKNLKIDITDNPYYQTFNFIVPIQLICGEIPTLRGVDPSV
                     PKDTRFHMKLGSKKLNK"
     gene            complement(8609..9409)
                     /locus_tag="KR257_003214"
     CDS             complement(8609..9409)
                     /locus_tag="KR257_003214"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003432375.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS system mannose/fructose/sorbose family
                     transporter subunit IID"
                     /protein_id="HBH0031885.1"
                     /translation="MNKLTKKELRSMFWRSFALQGAFNYERMQNLGYCYSMLPAIKKL
                     YNKKENQAKAIERHLEIFNTTTVVVPAILGITAAMEEENANNPEFDESSISAVKTALM
                     GPLAGIGDSLFWGTFRIIAAGVGVSLAKEGNIFGPLLFLLLYNIPAFALRIFGLKYGY
                     QVGVNSLERIQREGLMEKIMSMATTVGLFVVGGMVATMLSITTPLKFNLNGAEVILQD
                     ILDKIIPNMLPLTFAFVIYYMLKRKVSVTKLTIGTIVTGIALHAIGLL"
     gene            complement(9402..10193)
                     /locus_tag="KR257_003215"
     CDS             complement(9402..10193)
                     /locus_tag="KR257_003215"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004453987.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIC"
                     /protein_id="HBH0031886.1"
                     /translation="MLVQATMLAIIAGVGILDGRIFGQSMLDRPIVTGMLVGLVLGDI
                     KSGIMIGAQLELIWMGIAGIGAATPPDVVTGGVLGTAFAILSGNGAEVALAVAVPVAV
                     LAQSLGVLVRIINSYFSQKAVFYAKQADFKKVTIMMWLPVILFFLSTSVPTFLAIMIG
                     ADKVTALINAIPKVILDGLGVAGTLLPAVGFALLMDMLLSKKMSVFFFIGFLLASYGG
                     LDITAIALFGVCVAFVLNFYINNKENNQNPQLAINTLTEGEIDFE"
     gene            complement(10233..10655)
                     /locus_tag="KR257_003216"
     CDS             complement(10233..10655)
                     /locus_tag="KR257_003216"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891752.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS mannose transporter subunit IIA"
                     /protein_id="HBH0031887.1"
                     /translation="MKKFLIATHGELSRELVDTSKLIIGSLTNIEYFCMTTDKSADDA
                     EKEIRSILSNNKDSEEFVVLTDVFGGSVANICTNLLLQGFKFELLTGVNLPMLLSILL
                     LVEEDTKLIVKSGLEEAKNGIVYVNELLENQNKIKNVM"
     gene            complement(10671..11150)
                     /locus_tag="KR257_003217"
     CDS             complement(10671..11150)
                     /locus_tag="KR257_003217"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898441.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIB"
                     /protein_id="HBH0031888.1"
                     /translation="MVSLMRIDDRLIHGQVAYGWATSLGINVILVANDEAKNDQMKAM
                     SLNLAKPSNVTLYIRGVEESGEIVEKFASSKKSNVLVLVKNTKDALVVAKNSGGVLKE
                     INVGGLRYEEGKKKLTDLVAVDDDDINNFKQIGDLGIDIEFRMLPRDKKKQLSDLIK"
     gene            complement(11282..14038)
                     /locus_tag="KR257_003218"
     CDS             complement(11282..14038)
                     /locus_tag="KR257_003218"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893929.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sigma 54-interacting transcriptional regulator"
                     /protein_id="HBH0031889.1"
                     /translation="MRDEILSFVNECVLFNSFDELKKESGIITEDIVKKFNLSRTQSS
                     RLLNDLVKSDNLIKINSRPVIFLPKNKINDVVGPTKKSIYENLDELKNECKLLKQETV
                     FNSIIGYDNSLKEVIEQIKTAVLYPNGGLTIMLTGESGVGKTFLAKIIYKYSVSSNVL
                     EKNSPYNVLNCAQYYNNLELLSSLLFGHVKGAYTGANESRAGLIEQSDGGVLFLDEVH
                     RLNSEGQEKLFTFMDTGTFSRIGENGVIRKARVRLIFATTESLSEFLQTFLRRIPINI
                     YVPNIEERGTIEKRKIVEHFIYEESKVLGLPIEITQITLNAILKIKFKGNIGECKNVI
                     KYACGRAYAKNQRRNGNIFVTLQDLPRNLYIENVDIFQFQSGKSKSIIFSPKQFSIEM
                     SNGRNKRNIIYQSFIKCLDYFDRLEKNEITKEKFSKKSSNLMIRLMDNLVFSNNDENN
                     NVLMELIISIMQDIFRNLEVNNNIKYDGNNVLAFSSYLYLKDESYQLSDEYKALENKL
                     LIYLKKESYKEYSIISKISTLITNRLDMYLNNVDTIIMIIFIKSTIIRMKFNQVNATI
                     IAHGYATASSMANVCNRMLGKNIFTAIDMPIDATIADVSKQMSRYLEGDRIKNGLIVL
                     FDMGSLNLIYEDLKNKINSPMLFIDQISTISALEVGNLLMQGKNIEEIAEIMDEETKP
                     NIQLYYPQKNKEYAIISSCFTGIGIAIKIQHLLSESLIGIVDVKIIPYDYDSLVSMGD
                     KEPVFEMYDVMAIVGTANPNVNGVDFILLEDIISGKGEDDVFRIFSRVVENEKIKNIN
                     DSIVKNFSLIRVIDSLTILDSKKIIERIEEGINAIENIQKKKLSNDKKISLYVHLSCM
                     IERLVRQTEIEEYTDMDLLIKNHHSEVKLIKNAFSVLEKSYSVQIPISEIGYIYNIIY
                     GLPQ"
BASE COUNT         4610 a         2468 c         1614 g         5530 t
ORIGIN      
        1 aaaagccaaa attttaccta tcaataaaaa tcttaacgac taatactctt attttcaaat
       61 tttgcaacat ttttgttaat tttaaaacaa aaaaagacta tgcaatataa aaattatatt
      121 catagccggt tgcaccacta actccatata tctctagatg cccaataata agatatactt
      181 ctcagtttct aaaatatttt tattaaaaat cttttatata ttttcataaa tttctttttt
      241 attctaacat tgtaatatta ttttgtcaat atttccatat tcttagagat aagatactaa
      301 aatacctatt ttatctaaag atatttatat ttctacattc aataatagac aataccctgc
      361 aagttaaagc atcattttta tgagcttatc tcacagggta ttatatgttt actttatatt
      421 ataactcttg ttattgatta actttaataa atcctttttc tgaaacaagt gcttgtcctt
      481 catcacttaa tatataatct attaaagctt tacctttttc tgacaaacca tcttctttat
      541 taactaatat aaatggtctt gatattggat atttattagc tattacattt gcatcagttg
      601 cttcaacatc atttattttt aaactattta ctttctcatc aacatatcca aatgatatat
      661 atcctatagc attttcattt ccttcaactg tagtttttat atttcctgaa ccatcactta
      721 tttgtgcatc tttagttagt tcttctgaat caaaccctac aatttcttgg aatccatctc
      781 tagttcctga accttcttct cttgatacta ttactattgg tgcatcattt cctcctactt
      841 ctttccagtt agtaatcttt cctgtatata tacctttaac ttggtccatt gtcagatttt
      901 ttactgagtt tgcagtatta gttatcaatg ctataccatc tattgctatt ttagtttcct
      961 ttaatccagc acttttttct tcatctttta aatctcttga actcattcct atttcagatg
     1021 ttccttctat agcatttttt atacctccag aagaaccaat ctgttgtact tctacactaa
     1081 caccttgatt tttttcttga aacttttctc cgatagtttc cataagagga cctattgaag
     1141 ttgaacctga aacagaaact ttgcttgaat ctcctgaatc acctgaacct cctgagttag
     1201 aactacatcc tactgctaaa gctccaacta acattgtact agctaaaaga acgcctattt
     1261 tctttttaaa cattttactt acccccgctt atattttaat tttttgttgt catttttcta
     1321 tattttaata atacagattc tttgttaaat gaatattaga gcagggttaa gtaaatgtaa
     1381 atattgttaa atacatgtaa aaacttaatt ttatatgatt tattcttaat tagattaact
     1441 ttttaaagtt actttaggca gatataaaca taatacaact catattatca gaagtcttca
     1501 ttgaagctat caacctatca catcctataa ttctttttct agtttattaa ctaattcagc
     1561 aaatacattt aaggcttcct ctatagattc ttttttcgtc atatctacac cagcagattt
     1621 taattgttct agtgggtatt ctgaccctcc actttttaag aagtttatat atctatctac
     1681 tgcagtactt ccttctgaaa gtatctgttg acttaaagca cttgcagcag aaaaccctgt
     1741 ggcatactta tatacataga agtttgaata aaaatgaggt attctcgccc attctattcc
     1801 tatttgttta tctactattg cagattttcc gtaatacttt tcatttaatt tgtagtatat
     1861 attagtaaat tcatcagcag taagtggttc tccactctct accctttgat gtacaatttt
     1921 ttcaaattca gcaaacatag tttgtctatg aactgtagtt ctaaattgtt ctaaataata
     1981 atttaataag tatatagttt catccttaga cttagaattt tctaataaat aatttataag
     2041 aagtaattca tttaatgtag atgcaacttc tgcaacgaat atcttatagt ccgaatataa
     2101 aaatggttga cttgttcttg aataatgact gtgaacagag tgccctaatt catgaactaa
     2161 agtgaataga gaattaaggt catttttata gctcattaat atataaggat gtgaatcata
     2221 acttccccaa gaataagctc ctcctttttt accttcatta tcatatacat caatccaccc
     2281 ttcatcaaaa gcacttttta tgaccttcaa gtattcttct cctaaaggtt taagtgcctc
     2341 taatatgata tcctgtgctt tatcatatgg tatatccatg tcaaatttat ctgtcaaagg
     2401 aacatacaaa tcatacatgt gtatttcatt caatcctaaa aatttctttt taagctcaac
     2461 atatttattt agattaggaa tacttttatc tatagctgat ataagattat tgtaaacatc
     2521 taaacttaca tcatctgaaa ataaagacgc ttctattgct gaattatact ttctagtttt
     2581 tgcgtaaaat atctctgatt ttattccacc ataaagcgtt gaggcaaatg tatttttata
     2641 tttctcatat gttgaaaatt caccttcaaa agcgtctttt ctaactctac tattcttact
     2701 ttttataaat aaagagtagt ttgaatgaga aagcttaacc ttattcccct cctcatcttc
     2761 tatctcagga aattccatat ctgcatatgc taacatatcg tatacatttt ctggaattgt
     2821 cgataattct gatgtagctg caagtatttc ttcctctcgt tcactcaaag tatgtggttt
     2881 atctctcaat atatccttta tatattttgt ataaaaggat agcttctcat cttttaagta
     2941 ttcacttaac ttattctctt ctatcgccag tatttctgga actatataag aagtagccac
     3001 acctaaatca gtagataaca tttctgtctt agtggctctt ccttgattat cattaattct
     3061 agtatcttca tgttgtttca tatgagtata tacatataaa ttttgaacaa tcctagatgc
     3121 attttcagag atatttaata ctttatataa gttctcctta ctctcagaaa gcttcccttt
     3181 atattctttt acttcttgga taagattttt tactttactt atgtcttttt caatttcctc
     3241 tttactggag tacatcttat ctatcttcca tttgtacttt tcttctattg tacttctatc
     3301 agttcccata tcatacacct ctattttaat ttgttttata ttttattcac tttacaaaat
     3361 atattgtata tattttagtc caaataatct acatttatta ctccttctat catatttatt
     3421 tctttcataa catcgtgtaa gtgtattctc ttagcataag atacaaaaaa attaaccttc
     3481 cagtattctt cattacgaca ttctatttcc atatttctta cgataagttg atttttttca
     3541 aatttatcat ataaaaaagg tatagagtcc aaattgctta attttaatat caatacattc
     3601 ttttcttggc taaataaaaa cgtattgatt atcctaagca caaataatgc tatcattaca
     3661 aataatccac ctagaattgc caattcataa taaccatatc caactgctat accaatacat
     3721 gcagttgccc acatcccagc agctgtagta agccctttta ccccaccttt attttttaaa
     3781 attgctcctg cacctaaaaa accaattcca gataatactt gagcaggcat tcttgctggg
     3841 tcagcatttg tatacaaatt ataatcaaag aataattgaa tcgaagttat tgaaacaata
     3901 caagaaccta ttgcaattag tatatgtgtc ctaaatcctg caaactgtct tattttttct
     3961 ctctctaagc ctattattcc tcctattatt agtgctaata gtaaccttat tgctatctcc
     4021 ttacttccta tatcaatcat aatataaaac cctcctgact taattacaac ttatgtccta
     4081 cagataattt acacatcaga aatactattt tatatcttaa tattattatt aatatatgta
     4141 aaatatagcc atctgttaat ttttgataca aaaaaaccca caactgtggg ctatttgctt
     4201 aggtacatgt atttatttat taatatatct attttcttac ttgattctac taactcttct
     4261 tgaaatattt ctggatattc tatgtatgta tttatctctt ccctaactgc ttcaatctca
     4321 ttttttaacg cttctaattc attgttcgcc ataataatca ccactattac aaatttgtat
     4381 atttttatat acattttatc aaacaatatt atattttgtc aatattatgt caataaaact
     4441 tactataaaa atgctttaat ttaggtattg tatacctgga tactaagcct acaaacatac
     4501 cagttactaa tgatgccatt aacataaatg gtaagtaccc tatagcaagt atattttcta
     4561 tgattaaact tgcaactatt aattgaccta tattatgccc tattgcacct ataatgctta
     4621 tccctattag tgataaatct tttattttac tcgctaaata cataaataaa agactcagat
     4681 aagctcctcc tatactaaat agtagatatg ataaagggcc tgcaaatatt gatgacaaaa
     4741 ttaccctgat agtaacaatt ataacagtat ctttgacacc taacaacatt aatgaaatta
     4801 aagttataat attgctcaaa cccaattttg cccctggaaa tataactata agaggatttg
     4861 gtatatatgt ctctaataca tataaagcta aactataccc tatcataaga cctaaaaatg
     4921 tcatttttct agttttcatt aagttaactc ctccaaattt tatctatcat cttacattat
     4981 aatacaaaat atataaaaac acctaattta gactaaaata tttttaatct atttagaata
     5041 aatattagtt atttcaatgt gcaattacct ctataaatct tgactttttg tatcatactt
     5101 gttacaattt taatgataat gaatttcatt aggaggtgtt aataatgact gtttacgatt
     5161 taaaaatagg agaaaaagga tttattaata gtatagatgg agatattaaa ttatctaaaa
     5221 gattgcttgc acttggatgt ataaatagta ctgaaataga agttaaaaag gttgccccac
     5281 ttggagaccc aattataatt agatttagag gctttgacct tgcgattaga aaatctgatg
     5341 ctaaaaatat ttctttacaa taatagagga ggagctaccc gtgattaatg tagcattatt
     5401 aggaaaccca aatgtcggta aaactactgt ttttaatcta cttacaggtt caaatcaata
     5461 tgtaggtaac tggcctggtg ttactataga aaaaaaagaa ggatttcttg gaaaagagat
     5521 aaaggttgtc gatttacctg gtatatatgc aatggatact ttctcaaatg aagaaaaggt
     5581 ttctaaatca tatttagaaa atgaagatgt tgatgtaata gtaaatgtag ttgatgcttc
     5641 taatttatca agaaaccttt acttaacaac tcaacttatg caatttaaca agcctatagt
     5701 tatattgctt aatatgttag acattgcaga atctaaagga gttaatatag atgccaaaaa
     5761 attaagtgaa gaacttggag taattgttgt tccaattata gcaaaaaaga aaaatggtgt
     5821 tgataggata gaagaagaga ttaagggagc tacgcaaaaa gcttttatat atcagaaaaa
     5881 ctttggaagt gaaacagaaa catataaaaa attagaatcc attttatcga gatgtacaaa
     5941 aactacatat acacaaaaga aatctatcag tgataagata gacaatatag tcttgaatcc
     6001 tatattagca tatccgatat ttattggtgt attgttcctc ttatttaaat ttacctttga
     6061 ctgggtcgga ggaccactac aagagggatt tgctagtctt atagaggctt atatttctgc
     6121 acctgttagt gatatgttat ctaactctag cccatggttt aaatcactta tagttgatgg
     6181 aataattgga ggtgttggtg gtactttacc attcttccct ttaatattta cattattctt
     6241 tggtatatcg ttgtttgaag atagtggata catgtcaaga acagcatttt taatggataa
     6301 agttatgaga aaggttggtc tatctggtaa agcttttata cctatagtta tgggtatggg
     6361 atgttcttct ccagctataa tggcaactag aacattggaa agcgaaaaag atagaagagt
     6421 tacagctctt attgcaccac ttatgacttg tggagcaaag ctacctatat atgcactatt
     6481 tgtagctata ttctttccac ataatgctgc tttagtaact acatcactgt atttggtggg
     6541 tatagttatg gcaattgtag ttgcattatt cttaaataaa acagccttta aaacagaggc
     6601 tgaaccattt atattagaat taccagaata tagaatccct actatagatg cacttattaa
     6661 aaatacttgg aataaatcaa aaggtttctt gataagagtt gttactgtca tgtttgcaat
     6721 gtcagtcgta atttggggac tttcttcatt caatgttttt ggatatacag aagatataaa
     6781 tgtaagcttc ttggctactc taggtcatat tatatctcct atattcaaac ctcttggttt
     6841 tgatgattgg agaacttcag ttgctatttt aagtggtctt ggagcaaaag aaatcgtagt
     6901 aaactcttta aatatactat atggtaatct aactgttgtc ttaccaacaa tatttaatgg
     6961 agttactgca tatacattct tgatatttac tgctttatat actccatgta tagctgcact
     7021 tgcaactatg aaaaaagaat atggcaataa aatgatgttt acatcatttg catatcaatt
     7081 tatactagca tggataatgg cttttatagt taaaagtata ggtggagtac tatttatggg
     7141 taattcaata atggaagctt tgataggtgg aataattata gtccttgcac tctttattct
     7201 gtttaataaa ttcaagtcta caaaaaacgg aaatgtctgt agtggatgtt ctatttgttc
     7261 tggatgtcca agtgctaatt cttgctcaag taaggaagac agcaataaaa aaaataatgc
     7321 acactaatat ataaatattt tagtttaaaa taagataaaa gtgggtgtct caaaattaac
     7381 tttttagttc atgaggcact cttttttata taaaatcaaa tatattttca tcatttcaac
     7441 agtaaaaaag agcttatcta gtaaaaaaga ggcttatctc tattttgaga caacctcttt
     7501 ttttgttact tattcagttt cttgctacct aacttcatgt ggaacctagt atcttttgga
     7561 acacttgggt ctacacctct taatgtaggt atttccccac atattagttg tataggtact
     7621 ataaaattaa atgtttgata gtaaggatta tctgtgatat caatctttaa atttttatca
     7681 ttttctgtaa catctctacc tatagcaaat acattttccg tccaaccaga aagtacatca
     7741 atcatcttag ttactctagg ttcttttcct gtatctagta taaatatagt agaatcacta
     7801 tttatagcat tatatatacc atgtataaac tcttcaaact catacccagt tacaggtatt
     7861 ctcattgttt ccaataattt taatgctgct tctaatgtat ctccatatat atcagagtga
     7921 cctattattc ttatttcttt agaattaact aacttttctt tgtttctttc aatccattgt
     7981 ttagagagct tatacactgc ttcaaatcta ttaattgcgt ctaatatctt atttatttcc
     8041 tcattgtact tttcactaga tattatacct ttttctctag ctatttgaag acctaataac
     8101 attaagttta actttgtaca ataatatcct tttgttttag ctccagattt ttcttcacca
     8161 caatttactg ttaatatata atcagaaatc tcatctatta aagcattctt acaacctgcc
     8221 atagatgcta ttttacagcc cttatcttca gctaacttca tagcgttgta tgtagaataa
     8281 ctactcccac cttgagatac acctactact agggtatttt cattatcaaa cttgaatgta
     8341 tcttcagtta tcataaatgg atacattttc acaacatcta tatctaataa attttgtaaa
     8401 tatggttgca cctgcactcc tgagtgatag ctagtacctg aacctgttat tataatcttt
     8461 tttagatttg ttctcttaac ttcattaaat aagctatctg cattagatat aatttctctc
     8521 attctaactg gtgtttctaa catataatct tgtattgtca ttttatacac cttccttatc
     8581 tatatattca ataaattata attaatttct ataacaaacc tatagcatgt aaagcgattc
     8641 ctgttactat agtgcctata gttaattttg ttacacttac ctttctcttt aacatgtagt
     8701 atattacaaa tgcaaaggtt aaaggtaaca tattaggtat tattttatct agtatatctt
     8761 gtaaaattac ttctgcacca tttaagttga atttcagagg agtagttata ctcaacatag
     8821 ttgcaaccat tcctcctaca acgaataaac caacagttgt agccatagac attattttct
     8881 ccataagtcc ctctctttgt attctttcaa gagaatttac ccctacttga taaccatact
     8941 taagtccaaa tattctaagg gcaaatgctg gtatattgta taatagtaag aataatagtg
     9001 gtccaaagat attaccttct tttgcaagtg atactcctac tcctgctgct ataatcctaa
     9061 atgttcccca gaataatgaa tcaccaattc ctgcaagagg tcccataaga gctgttttaa
     9121 cagcactaat tgaactttca tcaaattctg gattattagc attctcttct tccatagcgg
     9181 ctgttatacc taatatagca ggaactacca ctgtcgttgt attaaaaatc tccaaatgcc
     9241 tttctattgc ttttgcttga ttttctttct tattgtatag cttctttatt gcaggtaaca
     9301 ttgaataaca gtaacctaag ttttgcattc tttcgtaatt aaatgcacct tgaagagcaa
     9361 atgaacgcca aaacatactt cttaattctt tttttgttaa tttattcaaa gtcaatctct
     9421 ccttccgtta aagtattgat tgctaattga ggattttgat tattttcttt gttattgata
     9481 taaaagttta gtacaaatgc tacacatact ccaaataaag ctatagcagt tatatctaat
     9541 ccaccataag atgctaacaa aaaccctata aagaaaaata cagacatctt ttttgaaagt
     9601 aacatatcca taagcaatgc aaaacctact gctggcaaca atgttcctgc aacacccaat
     9661 ccgtctaata taactttagg tattgcattt attaatgctg taactttatc agcaccaatc
     9721 ataattgcta aaaaggttgg aactgatgta cttaaaaaga ataatattac tggcaaccac
     9781 atcattatgg taactttctt aaaatcagcc tgtttagcat agaaaactgc cttttgagaa
     9841 aagtacgaat ttattattct aactaatact ccaagagatt gtgctaagac tgctactggt
     9901 actgctactg ctaaagcaac ttctgcacca ttacctgata atatagcaaa agctgtacct
     9961 aatacacctc ctgttactac atctggagga gtagctgcac ctattcctgc aattcccatc
    10021 caaattaatt caagctgtgc accaatcata attcctgatt ttatgtctcc taaaactaat
    10081 cctactaaca tacctgtaac tattggccta tcaagcatag attgaccaaa tatacgccca
    10141 tctagtatac caactcctgc tataatagct aacatagtag cttgtactaa catattgaac
    10201 ctccatttta acttagttta atttacatta aattacatta catttttgat tttgttttga
    10261 ttttctaata actcatttac ataaacaatt ccattttttg cttcctctaa tcctgattta
    10321 actattagtt ttgtatcctc ctcaactaat aaaagtatag ataaaagcat tggtaaattt
    10381 actcctgtca ataattcaaa tttgaaccct tgtaaaagta agtttgtaca tatgtttgcc
    10441 acacttccac caaacacatc tgttaagaca acaaattctt cactatcttt attatttgat
    10501 aatatacttc taatttcttt ctcagcatca tctgctgatt tatccgttgt catacaaaaa
    10561 tactcaatat tagttaatga accaattatt aatttacttg tgtcaacaag ctctctggac
    10621 aattctccat gtgttgcaat tagaaatttt ttcattctct ttctcctaaa ttattttatt
    10681 aaatctgata gttgtttctt tttgtctcta ggtaacattc taaattctat atcaatccct
    10741 aaatcaccta tttgtttaaa gttatttata tcatcatcat caacagcaac taaatctgta
    10801 agtttcttct tcccttcctc atatcttaat cctcctacat ttatttcttt taatactcct
    10861 cctgaatttt tagctacaac taaagcatct ttggtatttt ttactaacac taatacattg
    10921 cttttctttg aagaagcaaa tttttctact atttctccag attcctctac cccccttata
    10981 tataaagtta cattgctagg tttcgctaag ttcagtgaca tagctttcat ttggtcattt
    11041 tttgcttcat catttgcaac tagtattaca tttataccta gtgatgttgc ccatccatat
    11101 gcaacctgac catgtatcaa tctgtcatca attctcatca aagataccat tttccccaaa
    11161 tcctccatca tacattaaaa tttttattgt ttatactctc atttatctat aaaagcaaaa
    11221 agtatgccaa atactggcat acttttttaa atttcattca cttattttgt aatcttgtat
    11281 tttactgtgg tagaccatag ataatattat aaatatatcc tatctctgaa attggtattt
    11341 gcacactata actcttttct agcacactaa atgcattttt tattagtttt acttcactat
    11401 gatggttttt gattaacaaa tccatatcag tatactcttc aatttcagtt tgtctaacta
    11461 atctttcaat catacaactt aagtgaacat ataaagaaat ctttttatca tttgaaagtt
    11521 ttttcttttg aatattttct atagcattaa ttccttcttc tattctctct attatctttt
    11581 ttgaatctaa aatagttaga ctatctatta ctctaattaa tgaaaaattc tttacaatag
    11641 aatcatttat gttctttatt ttttcatttt ctactactct gctaaatatt ctaaaaacat
    11701 catcttctcc ttttcctgat attatatcct ctaataatat aaaatctacc ccattcacat
    11761 ttggattggc agttcctact atagccatca catcatacat ttcaaaaact ggttctttat
    11821 ctcccataga aacaagacta tcataatcat aaggtattat tttgacatca actattccaa
    11881 ttaaactttc ggaaagtaga tgttggattt ttatagcaat acctatccct gtaaaacaag
    11941 atgatattat agcatattct ttattttttt gaggataata caattgtata ttaggtttag
    12001 tttcttcatc cataatttct gcaatctctt caatgttttt accttgcatt aataaatttc
    12061 ctacttctag tgcagaaata gtggatattt ggtctataaa taacattggg ctatttatct
    12121 tattctttaa atcttcatat ataagattaa gagagcccat atcaaataat acaattaaac
    12181 cattctttat cctatctccc tctagatatc tagacatttg ttttgataca tcagcaatag
    12241 tagcatctat aggcatatca atagctgtaa atatattttt acccaacatc cgattacata
    12301 cattcgccat actactggca gtagcatatc catgtgctat aatagtcgca ttaacttgat
    12361 taaatttcat tcttataatt gttgatttaa taaatataat cattatgatt gtatctacat
    12421 tattaagata catatccaat ctattcgtta ttaatgttga tattttactt attatagagt
    12481 attctttgta actctctttt tttaaatata ttagtaattt attttctaaa gctttatact
    12541 catcagacaa ttgataagat tcgtccttca aataaagata agacgaaaat gccaatacat
    12601 tattcccatc atattttata ttgttattaa cttctaaatt tctaaatata tcctgcatta
    12661 tcgatattat aagctccata agtacgttat tattttcatc attatttgaa aagactaaat
    12721 tgtccattag tctaatcatt agattagaac tctttttact aaatttttcc tttgttattt
    12781 catttttttc tagtctatca aagtaatcta aacattttat gaaactttga tagattatat
    12841 ttcttttatt tcttccattt gacatttcaa tactaaattg tttaggagaa aagataatgc
    12901 ttttgctttt accactttgg aattgaaata tatctacatt ttctatataa agatttctag
    12961 gaaggtcttg aagagtaaca aaaatatttc catttcttct ttgatttttt gcataagctc
    13021 gtccacatgc atattttatt acatttttac attcacctat attccccttg aattttatct
    13081 ttaaaatcgc atttaatgta atttgagtta tctctatagg caaaccaagt accttacttt
    13141 cttcataaat aaaatgttct acaatctttc ttttttcaat agtccctctt tcttctatat
    13201 tgggaacata aatatttatg ggtattcttc ttaaaaaggt ttgtaaaaat tcagatagac
    13261 tttctgttgt agcaaatatt aatcttaccc tagcttttct aattactcca ttctctccaa
    13321 tcctagaaaa cgtacctgta tccataaatg taaataactt ttcctgacct tcactattta
    13381 atctatggac ttcatctaaa aataaaacac caccatctga ttgttctatt agacctgctc
    13441 tagattcatt tgctccagta tatgctcctt ttacatgccc aaataataga ctagacaata
    13501 actccaaatt attataatac tgcgcacagt ttaacacatt gtatggagaa tttttttcta
    13561 atacattact gcttacacta tatttgtata ttatcttggc taaaaaagtt tttcctactc
    13621 cactttcacc tgtcagcatt attgtaagtc cgccatttgg ataaagtaca gcggttttta
    13681 tttgttcgat tacttctttt aagctattat catatcctat gatactatta aacacagtct
    13741 cttgctttaa taatttacac tcatttttaa gttcatctaa attttcataa atactttttt
    13801 ttgtaggtcc tactacatca tttattttat ttttaggtaa aaaaataaca ggtctactgt
    13861 ttatctttat aagattatca gattttacta aatcatttaa taatctactt gattgagttc
    13921 tacttaaatt aaactttttt actatatctt ctgttattat gccactttct tttttaagtt
    13981 catcaaagct gttaaataat acacattcat ttacaaaact taaaatttca tccctcatgt
    14041 tcaacctcca atacaaatat caataatact ataatattag tatatcattt atatatttat
    14101 gaaaaagata attatattcc tatcttgatt ctcttttgta aggttgtaaa atcaaacttt
    14161 ttataagtat aaaatctaga ttttttaaca taatctcaag gttcttatct ttccatatat
    14221 ct
//
LOCUS       DAEPID010000093        14106 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.093, whole genome shotgun sequence.
ACCESSION   DAEPID010000093 DAEPID010000000
VERSION     DAEPID010000093.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 14106)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 14106)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..14106
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.093"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            95..712
                     /locus_tag="KR257_003219"
     CDS             95..712
                     /locus_tag="KR257_003219"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861041.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YmfQ family protein"
                     /protein_id="HBH0031890.1"
                     /translation="MDKEINLINYLPQILQDKEEYIKVFNVENKEIKTLHEKLNDLSS
                     DQFLEDLTPSGIKRWEKIMSITPKSNESLEDRRFRIFSKYISKLPYSERFLRNWLDSI
                     VGEGNYELTINNATYNIHLESDARNQDWFEEVHSFVSSIKPCNMTLDYTRVLVSKDNY
                     MNFGITTLIGQEITIYPWSPPDIETYGEIDVLTGNGVGYQEITIF"
     gene            724..1716
                     /locus_tag="KR257_003220"
     CDS             724..1716
                     /locus_tag="KR257_003220"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015984856.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phage tail protein"
                     /protein_id="HBH0031891.1"
                     /translation="MAIDKSYYTIITDVGKAKIANASVTGNKVGFVKIQLGDGGGSEY
                     TPTESQTALKNVVWEGNIGNTTTDETAPNCIILESLIPSSVGGFMIREIGYLDDENNL
                     IAISKYKECYKPSIEQGAVVDMKVKTVLIVSNVNNIELKIDPTIIFATLKDIQDLETK
                     IGTVNTKIDTTKTELTSNIETAKTELNTKIDQLIAGGSNVAYTQRVAIDDWVEDAESG
                     FKATVTHSLLTQRIVVNIIDATTKENIVPNFKIVDDNSIEIRSEVKVELNVYVINGNA
                     ETHFINATVDDNRVSEMTTYSSKKIEDRLVNIEEKVNGGLSNIATSVNELITYC"
     gene            1733..3445
                     /locus_tag="KR257_003221"
     CDS             1733..3445
                     /locus_tag="KR257_003221"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429874.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0031892.1"
                     /translation="MQTEWNFNYANYVQNVSLPPGRYKLECWGACGGAVDTSDWTDCA
                     KGGYSKGEIVFKKRTNLQICVGQSGYEKVSEGSSLTRSGFNGAGAAGKVTTGSFAYSK
                     YGGGATDIRLYHPSATWGNTESLLSRILVAGGGGGMKNNFASARSIGHGGGYVGVNGV
                     GRDRDFCGGGSQYQGGTSYDTEEYHGSLGKGGYGNIGIGGGGGWYGGAGSYSNECGGG
                     GSGYALNKDSYKVPGYIPTPEYYLENIVMTTGGNTTKADGYAKITLLQALPFLTVSSY
                     NSTQATFKADHTDPALLTKIEWFIDDVLKETITTNLTEEKTINYTLEDNALHTLKIVV
                     TDSNNATAEKVLSISKNIMPLPENVNLNDISTKLVEVNAGFKVGKTSIINTLALKNIE
                     ASLNNTLVELSEKIKTSFDSSDTSVQDLQNQVTQKNNTITQLETELSKRKRFITGTYT
                     FTKTDAENFNLSIYDKEGTSKTLTIPVNMGFSPSLIVLSGVTFSTTSKSYVYFDNVCN
                     SNFYNFGYNSDSTHSNPKAVGILNVSNVGYSSLVLTLYKLSMSEAVGIWAKEGATLTY
                     KIYI"
     gene            3466..3813
                     /locus_tag="KR257_003222"
     CDS             3466..3813
                     /locus_tag="KR257_003222"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429875.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0031893.1"
                     /translation="MNRNNRIIYDQTGNIWLQTGEATGDIQEWSKITELNFLDVEFGS
                     IDYSKQYIESINPVTKEPIIKDIEVILTDEQKRLQALEKELSMLKEENKNRDSEIVNT
                     AFEVENIKLNNNL"
     gene            3825..3995
                     /locus_tag="KR257_003223"
     CDS             3825..3995
                     /locus_tag="KR257_003223"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429877.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0031894.1"
                     /translation="MYNLLKLMIEQKNYSTKEDLQHKIDVFYAVNRITEEQYLELTSL
                     LNKEETPAEPIK"
     gene            4026..4592
                     /locus_tag="KR257_003224"
     CDS             4026..4592
                     /locus_tag="KR257_003224"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889434.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0031895.1"
                     /translation="MTFKELVNKVRNLVLEAKNVTIEDTESKFTSENVEGALKECIDR
                     ADEAFQEADSGKTLLSTAIGSPATSEQTFQDYANYITGFKSNISNLETQLKSKYSIRY
                     GPIDGYDGNPFSANFGKSASYLIVYVYFRRSVYYYNPSGSSLGSNTGGSERAWITIDS
                     NKTGFSVHSYDTSYEPYPFTGYYIACFA"
     gene            4623..4913
                     /locus_tag="KR257_003225"
     CDS             4623..4913
                     /locus_tag="KR257_003225"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009894397.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0031896.1"
                     /translation="MEEISINLLCAVAGVVISYLAFRNSSNRKIQDDTETTTKLEQQI
                     TFLCENVRDIKHDVAKFNTSFLDISERVAKVEASTKQAHLRIDEIINRIGGK"
     gene            4917..5174
                     /locus_tag="KR257_003226"
     CDS             4917..5174
                     /locus_tag="KR257_003226"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889440.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phage holin family protein"
                     /protein_id="HBH0031897.1"
                     /translation="MDNLISFIPEQLLILVAALYVIGAGCKKYKQLDNKYIPVVLLIL
                     GIGFSIWMLGLNPVAVLQGVICWGVAIGVNQTYKQFKDGEK"
     gene            5435..6298
                     /locus_tag="KR257_003227"
                     /pseudo
     CDS             5435..6298
                     /locus_tag="KR257_003227"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429958.1"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="Abi family protein"
     gene            6377..7189
                     /locus_tag="KR257_003228"
     CDS             6377..7189
                     /locus_tag="KR257_003228"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018112536.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="N-acetylmuramoyl-L-alanine amidase"
                     /protein_id="HBH0031898.1"
                     /translation="MKICITVGHSILKSGACTSADGVVNEYQYNKSLAPVLADTFRKE
                     GHKADVIICPEKQFKTKAEEKTYKIPRVNSGGYDLLIELHLNASDGQGKGSEVLYYSN
                     KGLEYATRICNKLGTVFRNRRAKLDKGLYILNSSNPTAVLIESFFCDNKEDYEKAKKL
                     GHEGIAKLIVEGVLNKNINNEGVKQMYKHTIVYDGEVDKISATVVGWGYNDGKILICD
                     IKDYVPGQTQNLYVIGGAACEKIGSMTKEKFTMIKGNDRFDTLYKALDFINR"
     gene            7283..9682
                     /locus_tag="KR257_003229"
     CDS             7283..9682
                     /locus_tag="KR257_003229"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893147.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell wall-binding repeat-containing protein"
                     /protein_id="HBH0031899.1"
                     /translation="MIFKKYIKSLLIVVSVTLIMNKSILFVNALDLESNNNIKSYKRK
                     NVKEIDISNKFVDESFRRDIVEKVLDNRDDPLTNEVASKDNYKIYESDLNKIESCLEL
                     DLHKNPDVSNPNKIDNLDGIENFRNLEKLDCSSNNLESVDLSKNIKLKYLDISGNKIL
                     NINLKNNNLINELHCDANKLSSLDLKNNKNLVSLFFTSNELTEIDLSNNVNLENLQFL
                     NNNLKSIDLSHNKKLKSLNCTNNKLKSLNLSNNVFLKNLSCSGNNLSKLNIKGLTSLE
                     YLGCAKNKLQDLDVSTNIKLDSLFCGKNSLTKIDISKNKELKSLECSGQYIEKSIIKN
                     GENIVVDIGIENSKLKELYPQNYNISTGFLTWKNISEFPNNVSYSLEYEYGPVNDVET
                     MDVNISIDKLVKCRIRYIDYDGSIINEKEISDNSSINEIQINPQRENYEFNGWRNNKD
                     EKIYTSEQVSKLVFDDSTDFIATYKRKSTGSSGSSGGTSSKEDFNIAPSKEKLTGADR
                     NETSVKISQKGWNKADNIVLINDSSISDALSATPFAKSKDAPILLTKNNNLNKLTEKE
                     INRLEAKNVYIVGGLKSVDEKVVSDLKKKGLNVIRISGNDRYETSIKLAKELDKNSNL
                     SKVVVVNGEKGLADAVSMGAISAKEEMPILLTNQNDDMKDIKDLIANKNISKSYVIGG
                     ESLFNNKEVNNTLPSVTKIAGSDRTETNSKVISHFYSKDTLNDLYVAKNGMNKQDDLV
                     DALSVGVLAGKTESPVVLVGNGLDDSQKELIKNKKFKNITQIGGNGNEKAFNEVENLV
                     K"
     gene            complement(9723..9908)
                     /locus_tag="KR257_003230"
     CDS             complement(9723..9908)
                     /locus_tag="KR257_003230"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003433687.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AbrB/MazE/SpoVT family DNA-binding
                     domain-containing protein"
                     /protein_id="HBH0031900.1"
                     /translation="MILLEQRKLRVAFNKSGKGSFTPRLILPMSWIKEMNISPDERDV
                     LVTFEDGKIIIEKTENE"
     gene            complement(10456..10632)
                     /locus_tag="KR257_003231"
     CDS             complement(10456..10632)
                     /locus_tag="KR257_003231"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0031901.1"
                     /translation="MEQKESKIVYSKGGSGTYSAKISLPLSQLEKMGFTREKRKAVVI
                     FKEDEIIIKKSDEE"
     gene            11349..12026
                     /locus_tag="KR257_003232"
     CDS             11349..12026
                     /locus_tag="KR257_003232"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420135.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="manganese catalase family protein"
                     /protein_id="HBH0031902.1"
                     /translation="MFKHDKALLKEVKVERPNPQYAVLMQEQLGGANGELKAAMQYLS
                     QSFRIKDPQIKDLFLDIAAEELSHMEMVAQTINLLNGHDVDYNSVNTGEIETHVLTGL
                     SPVLINSSGAPWTANYVTVTGDLVADLLSNIASEQRAKVVYEYLYRQIDDKYVKETID
                     FLLNREEAHNALFRDALNKVKDTGSNRDFGVTEDSKLYFDLSTPGPNHDTKIDINPPS
                     FEKPLKK"
     gene            12200..>14106
                     /locus_tag="KR257_003233"
     CDS             12200..>14106
                     /locus_tag="KR257_003233"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429971.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="thioredoxin domain-containing protein"
                     /protein_id="HBH0031903.1"
                     /translation="MDSNRKPNNLINEKSPYLLQHAYNPINWYSWNDEAFKKAKEEDK
                     PIFLSVGYSTCHWCHVMEKESFEDEEVAEIMNRNFVAIKVDKEERPDVDSVYMTVCQA
                     MTGSGGWPMTIIMTPDKKPFFAGTYFPKYSRYNRPGVIDLLENVSEKWNTSRDILIKS
                     GDEIIEALKDDFGVKNTEGDLSKEMLSSSVRVFKAIYDEKYGGFGNAPKFPSPQNLMF
                     LMKYYSIEKDKDVLKMVEKTLDGMYRGGLFDHIGFGFSRYSTDKKWLAPHFEKMLYDN
                     AMLTIAFLDAYKITKKELYKEIAIKTIDYVVREMKDKEGGFYSAQDADSEGEEGKFYT
                     FNPLEIIEVLGEEDGIFFNNYFDITSSGNFEGKSIPNLIKNKEYERHNEKIADLSKKV
                     FEYRKERTSLHKDDKILTSWNALMIVALTKAYSTLKNDIYLEYSNKCLNFINNNLVNE
                     SGRLLARYRDGSSDYLAYLDDYAFLIWAYIELYESTFNMKYLEKALNLNESCINLFWD
                     YEKSGFYIYGKDSENLIARPKDLYDGAIPSGNSVQLYNLIRLAKITGDNRLEEMSYKQ
                     LKLYVDNVKSSPTGYSFYMLSLMFELYSTKEIICIFKEDSDLIAFKELISENFIPNAT
                     FLAKKYNEENT"
BASE COUNT         5681 a         1550 c         2412 g         4463 t
ORIGIN      
        1 gatggagtgt tagatattac aaacacaatg ataaatgatg ttaaatctaa tctaacaata
       61 gatagtaaca gtatagtagt gagaggtgag gtagttggat aaagagatta atctaataaa
      121 ttacttacca caaattctac aagataaaga agaatatata aaagtattta atgtagaaaa
      181 caaagaaata aaaacactac atgaaaaatt aaatgaccta tcaagtgacc agtttttaga
      241 ggatttaact ccaagtggta taaaaagatg ggaaaagata atgtctataa ctcctaaaag
      301 taatgagagt ttagaagata gaaggtttag gatttttagt aaatatataa gtaaactacc
      361 ttactcagag agatttttaa ggaactggct agatagtata gttggagaag gcaattatga
      421 attaactatt aataatgcta cttataatat acatcttgaa agtgatgcta gaaatcaaga
      481 ttggtttgag gaggttcatt cttttgtaag tagtattaaa ccttgcaaca tgactttaga
      541 ttacactaga gtgcttgtaa gtaaagacaa ttatatgaat tttggtataa caaccctaat
      601 aggtcaagaa ataactatat acccttggag tccaccagat atagaaactt atggagaaat
      661 tgatgtatta actggcaatg gagttggata ccaagagata acaatatttt aggaggtgat
      721 atattggcta tagataaaag ttattacact ataattacag atgtagggaa agcaaagata
      781 gcaaatgcaa gtgtcacagg taataaagtg ggatttgtaa aaattcaact tggtgatgga
      841 ggagggagtg aatatactcc aactgagagt cagacagctc tcaaaaatgt ggtatgggaa
      901 ggcaatatcg gaaatacaac tacagatgaa actgcaccaa attgtataat attagagagt
      961 ttaataccat caagtgtagg cgggtttatg ataagagaaa taggatattt agatgatgaa
     1021 aataatttaa ttgccatttc taaatacaaa gagtgttata aaccttctat agaacaaggt
     1081 gcagtggtag acatgaaggt taaaactgtg cttattgtat ctaatgtaaa taatatagaa
     1141 cttaaaattg acccaacaat aatctttgca acactcaaag atatacaaga cttagaaact
     1201 aaaataggta ctgttaatac taaaattgat acaactaaaa cagaattaac aagcaacata
     1261 gaaactgcta aaacagagtt aaatactaaa atcgaccaat taatcgcagg tggctcaaat
     1321 gttgcataca ctcaaagggt cgcaattgat gattgggttg aggatgcaga aagtggattc
     1381 aaagcaactg taacacatag tttattaaca cagagaatag ttgtaaatat tatagatgct
     1441 actacaaaag aaaatatagt tccaaatttt aaaatagttg atgataattc aattgagatt
     1501 agaagtgaag taaaagttga gttaaatgtc tatgtgataa atggaaatgc agaaactcat
     1561 tttataaatg caactgtaga tgataacaga gtatctgaaa tgactactta ttcatctaag
     1621 aaaatagagg acagattggt taatatagaa gaaaaggtaa atggtggttt atctaatatt
     1681 gcaacaagtg taaatgagtt gataacttat tgttagagag gagagtgaga aaatgcagac
     1741 tgaatggaat tttaattatg ctaattatgt acaaaatgtt tcattgccac ctgggcgata
     1801 taaattagaa tgttggggtg cttgtggtgg tgctgtcgat acaagcgatt ggactgattg
     1861 tgcaaaaggt ggttattcaa aaggtgagat tgtatttaaa aaaagaacta atctacaaat
     1921 ttgtgtcggt caatccggtt atgagaaagt ttctgaaggt tcaagcctta ctagaagtgg
     1981 ttttaacggt gcaggcgctg ctggcaaagt tactactggt agctttgctt attctaaata
     2041 cggtggtgga gcaactgata taagacttta tcatcctagt gcaacttggg gtaacaccga
     2101 aagtttgctt tcacgcatac ttgttgcagg cggtggagga ggtatgaaaa ataattttgc
     2161 ttctgctcgt tctattggtc atggtggtgg ttatgtaggt gttaatggag ttggtcgtga
     2221 cagagatttt tgtggcggtg gttctcaata ccaaggtgga acaagttacg acacagaaga
     2281 ataccatggt tcattaggaa aaggaggtta tggtaacata ggaataggtg gtggaggggg
     2341 ttggtacggt ggtgctggtt cttattctaa tgaatgtgga ggtggtggaa gtggttacgc
     2401 actaaataaa gatagttata aggtacccgg atatatacca acacctgaat attatcttga
     2461 aaatatagtc atgactactg gaggtaatac tactaaagca gatggttatg ctaaaataac
     2521 attactacaa gcattgccat ttttaacagt atcttcttat aattctacac aggcaacatt
     2581 taaagccgac cacacagacc ctgcattact tacaaagata gaatggttta tagatgatgt
     2641 actaaaagaa actataacaa caaatttaac agaagagaaa acaattaatt atacattaga
     2701 agataatgca ttacacacac ttaaaatagt tgttacagac agtaataatg ctacagcaga
     2761 aaaagtgtta agtataagta agaatataat gccactgccc gaaaatgtaa atttaaatga
     2821 tatatcaaca aaattagttg aggttaatgc aggatttaaa gttgggaaaa caagtattat
     2881 aaacacttta gcacttaaaa atatagaagc aagtttaaat aatacacttg tggagttatc
     2941 agagaaaata aaaacaagtt ttgatagttc agacactagt gtgcaagatt tacaaaatca
     3001 agtaacacaa aaaaacaata ctataactca attagaaaca gagttaagta aaagaaaaag
     3061 atttataaca ggaacttata cattcacaaa aacggatgca gagaatttta acttaagtat
     3121 atatgacaaa gaaggaactt caaaaactct tactatacca gttaacatgg gcttctctcc
     3181 tagtttaatt gtacttagtg gagtaacttt tagtacaaca agtaaatctt atgtttattt
     3241 tgataatgtt tgtaattcaa atttttataa ttttggctat aattctgatt ctactcatag
     3301 taacccgaaa gctgttggta ttcttaatgt atctaatgtt gggtattctt cattagtgct
     3361 tacattatat aaattatcaa tgtcagaagc agttggaata tgggcaaaag agggagctac
     3421 attaacttac aaaatatata tttaataaaa aaatgaggtg ataatatgaa cagaaataat
     3481 agaataattt acgaccaaac aggcaatata tggcttcaaa ctggtgaagc aacaggagat
     3541 atacaagagt ggtcaaaaat aactgaatta aattttttgg atgttgaatt tggtagtata
     3601 gactatagta aacaatatat agagtctata aatccagtta caaaagaacc aatcatcaaa
     3661 gacatagaag tcattttaac agatgaacaa aagagattac aagcattaga aaaagaatta
     3721 agcatgttaa aagaagaaaa taaaaataga gatagtgaga tagtaaacac agcctttgag
     3781 gtagaaaata taaaattaaa taacaattta taggaggaat taacatgtat aacttattaa
     3841 aacttatgat agaacaaaag aactatagca ctaaagagga tttgcaacac aaaattgatg
     3901 tattctatgc agtaaataga attacagaag aacaatattt agaacttaca agtttattaa
     3961 ataaagaaga aacaccagca gaaccaataa aataggttct ttttttattg aaagaaggtg
     4021 actaaatgac ttttaaagag ttagttaata aagttagaaa tcttgtatta gaagcaaaga
     4081 atgtaactat agaagataca gaaagtaaat ttacaagtga aaatgtagaa ggagcattga
     4141 aagaatgtat agatagagca gatgaggctt ttcaagaagc cgatagtgga aaaacacttt
     4201 tatcaactgc tatcggctct cctgctacat cagaacaaac atttcaagat tatgcgaact
     4261 atattacagg atttaagagc aatataagca atttagaaac tcaattgaaa agcaaatatt
     4321 ctattagata tggtcctatt gatggatatg atggtaatcc tttttctgct aattttggca
     4381 agagtgcaag ttaccttatt gtctatgttt actttagaag aagtgtatat tattataatc
     4441 ccagtggtag ttctttagga agtaatacag gaggttctga acgtgcatgg attactatag
     4501 acagcaataa aactggtttt tcagttcatt catatgatac tagttatgag ccatatcctt
     4561 ttacaggtta ttatattgct tgtttcgcat aataaattat attattaaaa ctaggaggat
     4621 gtatggaaga aattagcata aatctattat gtgcagttgc aggagttgta atatcctact
     4681 tagcatttag aaatagctca aacagaaaga tacaagatga tacagaaaca actacaaaat
     4741 tagaacaaca aataactttt ctgtgtgaga atgtaagaga tataaagcat gatgtagcaa
     4801 agtttaatac aagtttctta gatatcagtg aacgagttgc aaaagtagaa gcaagtacaa
     4861 aacaagcaca tcttagaatt gatgaaatta taaatagaat tggaggaaaa taaaagatgg
     4921 ataatttaat aagttttata ccagagcagt tactaatttt agtagctgct ctttatgtta
     4981 taggagcagg ttgcaaaaaa tataaacaat tagataataa atacattcca gtagtgttat
     5041 tgatacttgg aataggtttc tcaatatgga tgctaggatt aaatcctgtt gcagtcttac
     5101 aaggtgtaat ttgttgggga gttgcaatag gtgtaaatca aacttacaaa cagtttaagg
     5161 atggtgaaaa gtaatgaaat taacaaaaat attattactc acaaaaattt aaaaaatttc
     5221 attaaataga gtatactttt atagctaata agtatataat aatagtacag aactcgtaaa
     5281 gcatttatat gctcaaatat acgggacatt gatttttgaa ggaacccgcc aagcttcttt
     5341 tatagctcaa atagtcggga cagataaatt tacccactaa tattaattgg tgggttttat
     5401 tatataaaag tatatctatg aaaaggtgaa aacaatggtt gaagtaaaag aagaaaaaac
     5461 atttgatgaa caaatagata ttttaaaaag tagaggatta ataataaatg ataaagaaga
     5521 tgctaaattt gtattaagta atgtcaatta ttataggttt acagcatatc ttctaagttt
     5581 taagaatgat gatggctcat ataaagaagg aactacgttt gaagaagttt atgatatata
     5641 taggtttaat aaggaattta ggatattatt aacagatttg ttagggagca tagaaatagc
     5701 atttaggaca tacattgcat atacattagc aattaaacat ggtgcttgtg gatatctata
     5761 aagggagagt ttcaaagatg aaaaattcta tattaatttt ttgacagcat tagagagaga
     5821 aaaaaataat aattcagata agctttttat tatacaccat aaagaaaaat ataaaggaaa
     5881 acttcccatt tgggttgcaa cggaaataat gacttttggt atgttgtaaa aattatattc
     5941 aaacatgttg ccagaagata ctagatacat aaaaaataat ttgtgtagag tgaatacttt
     6001 attagttaaa tcttggttac aatcattaac acaggtcaga aatcaatgcg ctcattatgg
     6061 tagaatatat aataataatt tccgtattat aacaataaaa aacgaatata aaaagtataa
     6121 cttggataat aaaaagatat tttcttatat acttgctatg aagcatttga ctatggataa
     6181 attaatttgg aatagttttt ttataaaact tcaaaagtta attaatgatt ataataattc
     6241 tatagactta aagcttattg gttttcctaa taattggata gagatattgg ctaaataaaa
     6301 tagttacttt aagaagttta taaacactta ctatatgtaa gtgttttttt attgaaaaga
     6361 aggaggaaaa taaataatga aaatatgtat tacagtagga cacagtattt taaaaagtgg
     6421 tgcatgcact tctgctgatg gagtagttaa cgaataccaa tacaataaat ctcttgcacc
     6481 agtattagca gatacattta gaaaagaagg tcataaggca gatgtaataa tatgccctga
     6541 aaagcagttt aaaactaaag cagaagaaaa gacttataaa atacctagag ttaatagtgg
     6601 aggatatgat ttacttatag aactacatct aaatgcaagt gatggtcaag gaaaaggttc
     6661 agaagttcta tattatagta ataaaggttt agaatatgca actagaatat gtaataagct
     6721 aggtacagta tttagaaata gaagagctaa attagataaa ggattatata tcttaaatag
     6781 ttcaaatcct acagcagtat taattgaaag tttcttctgt gataataaag aagattatga
     6841 gaaagctaag aaactaggtc atgaaggtat tgctaagtta attgtagaag gtgtattaaa
     6901 taaaaatata aataatgagg gagttaaaca gatgtacaaa catacaattg tttatgatgg
     6961 agaagttgac aaaatctctg caactgtagt tggttggggt tataatgatg ggaaaatact
     7021 gatatgtgat ataaaagatt acgtgccagg tcagacgcaa aatctttatg tcattggtgg
     7081 tgcagcatgt gagaagattg gttctatgac taaagaaaaa tttactatga taaagggtaa
     7141 tgatagattt gatacacttt ataaggcatt agattttatt aatagataga ttatataaaa
     7201 tattttagta tttcttgaaa atcataagta tggtaatatt tagataaata ttatttatta
     7261 ttaataggta tgggggtaga ttatgatatt taagaagtat ataaaatcat tactgatagt
     7321 tgttagtgtt acattgataa tgaacaaatc aatattattt gtaaatgcat tagatttaga
     7381 gagtaacaat aacataaaat cttataaaag aaagaatgta aaggaaattg atataagcaa
     7441 taaatttgtt gatgaatcct ttagaagaga tattgttgaa aaggtattag ataataggga
     7501 tgatccatta acaaatgaag ttgcatcaaa agataactat aaaatatatg aaagtgattt
     7561 aaataaaatt gagagttgct tagagttaga tttacataaa aatccagatg tttccaaccc
     7621 aaacaaaata gataatttag atgggataga aaattttaga aatctagaaa agcttgattg
     7681 tagttcaaat aatctagaaa gtgtagattt aagtaaaaat ataaaattaa aatatctaga
     7741 tattagtgga aataaaatat taaacattaa tttaaaaaac aataatctta ttaatgaatt
     7801 acattgtgat gcaaataaat tatcaagttt agaccttaaa aataataaaa atttggtaag
     7861 tttatttttt actagtaatg aattaacaga gatagattta agtaataatg tgaacttaga
     7921 aaatttgcaa tttcttaata ataatttaaa aagtatagat ttaagtcata ataaaaagtt
     7981 gaaatctcta aattgtacta acaataaact taaatctctt aatttaagta ataatgtttt
     8041 tttgaaaaat ttaagttgtt caggtaataa cctaagtaaa ttaaatataa aaggacttac
     8101 aagtcttgag tatttgggat gtgctaagaa taaattacaa gatttagatg tatctacaaa
     8161 tataaaatta gattctttat tttgtgggaa aaatagttta acaaaaatag atataagtaa
     8221 aaataaagaa ttaaaatcat tggaatgtag tggtcaatat atagaaaaaa gtattataaa
     8281 aaatggtgaa aatatagttg tagatatagg aattgaaaat tcgaaattaa aggaattata
     8341 tccacaaaat tataatatct caacaggttt tctaacatgg aaaaatattt ctgaatttcc
     8401 aaataacgta agttatagtt tggaatatga atatggtcca gtaaatgatg tagagactat
     8461 ggatgtaaat atatcaatag ataaattagt taaatgtaga atcagatata tagattatga
     8521 tggaagtata atcaatgaaa aagaaatatc agataattct agtataaatg aaattcaaat
     8581 taatcctcaa agagaaaact atgagtttaa tggttggaga aacaataaag atgaaaaaat
     8641 atatacatca gagcaggtaa gtaaattagt ttttgatgat agtactgatt ttatagcaac
     8701 ttataaaaga aaatcaacag gatcaagtgg ttcttctggt ggaacttcaa gtaaagaaga
     8761 ttttaatata gcaccatcta aggaaaaatt aacaggtgca gacagaaatg aaacatcagt
     8821 gaaaataagt caaaaaggat ggaataaagc tgataatata gtgttaataa atgactctag
     8881 catatcggat gctttatcag caacaccatt tgctaagtct aaagatgcac caatattact
     8941 tactaaaaat aataacttaa ataaattaac agaaaaagaa ataaatagat tagaagcaaa
     9001 aaatgtgtac atagtgggtg gattaaagtc tgttgatgaa aaagtagtgt ctgatttaaa
     9061 gaaaaaagga ttaaatgtaa ttagaatatc tggaaatgat agatatgaaa catcaataaa
     9121 acttgcaaaa gaattagaca aaaattctaa cctgtcaaaa gtagtagtgg taaatggaga
     9181 aaagggacta gctgatgcag taagtatggg agctatatca gcaaaagagg aaatgccaat
     9241 tcttcttact aatcaaaatg atgatatgaa agatataaaa gacttaatag ctaataaaaa
     9301 catatcaaaa tcatatgtaa taggtggaga atctttattt aataataaag aagtgaataa
     9361 cacattacca tctgtaacta aaatagcagg ttctgataga acagaaacta actcaaaagt
     9421 aataagtcat ttctatagca aagatacact taatgactta tatgtagcta agaatggaat
     9481 gaataaacaa gacgatttag tagatgcctt atcagtagga gtgcttgcag gtaaaactga
     9541 atctccagta gtattagttg gaaatggatt agatgatagc caaaaagagt taatcaagaa
     9601 taaaaagttt aaaaatataa ctcaaattgg tggaaatgga aatgaaaaag catttaatga
     9661 agtagaaaac ttagttaaat agattgaaag gtagtaactg gaaatagtta ctacctcctt
     9721 ttttattcat tttcagtttt ttcaataatt atttttccat cctcaaaagt aacaagaaca
     9781 tccctttcat caggagagat attcatctct ttaatccatg acattggaag tatcaatctg
     9841 ggtgtaaaag agcctttgcc acttttattg aatgcaactc taagttttct ttgttccaat
     9901 aatatcattc ctttctacta ttaataaatg ccagcaataa taaagtaaat accaaagcaa
     9961 taagagcttt aaaagtaaaa cttattatta tattaataat atttaaaact atagtgatac
    10021 caagaataat catacaaatt ctataaaatt tattattcat attaaattag aaaatgtgtt
    10081 ataatattag aaagaagcta cctagaagga aggtattttc ctcctaggat tgaaacttat
    10141 aattctttaa tcaatcttag tattgcgagt actagattaa ttaaaactaa tgtgaaagag
    10201 aaagcatttt taattttatt aaatttgttt tctcttttat tttttcttct ttctaatctc
    10261 cccactttct ttgtcctccc ttctaagttt tttattttct tacctccttt ctatatttat
    10321 attatatcat cacgtgacgt gaaagtcaat aaatattcca tatttttcaa taaagctata
    10381 aaatatatta atataaaata caaaatataa taaaaataag tggatgttta cattatacac
    10441 ccacttattt tagagttatt cctcatcaga tttttttatt ataatctcat cttccttaaa
    10501 aataactaca gccttacgtt tttcccttgt aaatcccatt ttttcaagtt ggcttaaagg
    10561 taaagaaatt ttagccgaat aagtacctga accaccttta ctgtaaacta ttttagattc
    10621 tttttgctcc aaactatttt cctccttttt tatattgtaa tgtaacaaat attaacaata
    10681 aaatgcttac tattaatcct attatattgt tgatattaaa atgtaaaaat aaaagtatta
    10741 tgtctattac tatagttata gcaactataa taagacagaa tttataaact ttatcactca
    10801 tattttatag aaaatgtgtt ataatattta gaaagaagtc actaggaaga agattaaatt
    10861 cttcctagct tacaaaacta taaatctttt aataatttaa ttagtttatc aattaaattt
    10921 attaaaatgg gtaagataga gagagcagtt ttaactttgg cgagtttgct ttctctatct
    10981 ttttttcttc tttctattct actcattttc cttttcaccc cctttctata tttatattat
    11041 aatatgccga accggcaaaa gcgatattta tttccatatt tttcaataaa gttatattga
    11101 caaactatat ttttttacaa ataaaaataa gggtggcaaa accaaacttg ccaccctttt
    11161 gccaccgaaa ataaataata gaataaattt aaattaaaca taataaaaca taaacaacaa
    11221 aactgacctt aataaaacat tgaaatacca acacttgtaa aaaataacaa caataaacaa
    11281 ataacctaga ataatattac aacttaagta aataataatt ttgaataata atttacggag
    11341 gtattcatat gtttaaacac gataaagcat tattaaaaga agtaaaagta gaaagaccaa
    11401 atcctcaata tgctgtttta atgcaagaac agttgggtgg tgcaaatgga gagttaaaag
    11461 cagctatgca atacttgtcc caaagtttta gaataaaaga ccctcaaata aaagatttat
    11521 ttcttgatat agcagcagaa gagcttagcc atatggaaat ggtagcacaa actataaatt
    11581 tattaaatgg acatgatgtt gattataatt cagttaatac aggcgaaata gaaacacatg
    11641 tattaactgg tctatcacca gtcttaataa actcatcagg agctccttgg actgctaatt
    11701 acgttacagt tacaggggat ttagtagctg acttactttc aaatatagct tctgaacaaa
    11761 gagctaaggt agtttatgag tacttgtata gacaaataga tgataaatat gtaaaagaaa
    11821 caatagattt cttacttaat agagaagaag cacataatgc tctatttaga gatgctttaa
    11881 ataaagttaa agatacaggt tcaaatagag attttggagt tacagaagat tctaaattat
    11941 atttcgattt gtctactcca gggccaaatc acgatactaa gatagatatt aatcctcctt
    12001 cttttgaaaa acctttaaaa aaataatttg atatttttta tgttgttttg ttttagtagt
    12061 tataaaaatt atttactagg agaattaatt atatgaaaaa ttaaatatgt atggttaaaa
    12121 atgggtatac acttattata agtgtatatc tatttgttta ttgcaaaaca tataataaaa
    12181 taacaaatga ggtggtattt tggacagtaa tagaaaacct aataatctaa taaatgaaaa
    12241 atctccatat cttttacagc atgcatataa tcctataaac tggtatagtt ggaatgatga
    12301 ggcttttaaa aaagcaaaag aagaggataa gccaatattt ttaagtgtag gatattcaac
    12361 atgtcattgg tgccatgtta tggaaaaaga atcttttgaa gatgaagaag ttgctgaaat
    12421 aatgaataga aactttgtgg cgataaaagt agataaagag gaaagacctg atgtagatag
    12481 cgtgtatatg acagtttgcc aagccatgac aggtagtggt ggatggccaa tgaccataat
    12541 aatgacacca gataaaaaac ctttttttgc gggaacatat ttcccaaaat attcaaggta
    12601 taatagacct ggagttatag atttattaga gaatgtatct gaaaagtgga atacaagcag
    12661 ggatatatta ataaaatctg gagatgaaat aatagaagct cttaaggatg attttggtgt
    12721 aaaaaatact gagggtgatt tatcaaaaga gatgttgagt tcatcagtta gagtatttaa
    12781 ggctatttat gatgaaaagt atggtggttt tggtaatgct cctaaatttc caagtcctca
    12841 gaatcttatg tttttaatga aatattatag tatagaaaaa gacaaagatg tgttaaaaat
    12901 ggtggaaaaa actttagatg gaatgtatag aggaggcttg tttgatcata ttggatttgg
    12961 gttttcaaga tactctactg ataaaaagtg gttggctcct cattttgaaa aaatgctata
    13021 tgataatgct atgcttacta tagctttttt agatgcgtat aaaataacaa agaaagagtt
    13081 atataaagaa attgctataa aaactataga ttatgtagtt agagagatga aggataaaga
    13141 aggtgggttt tattcagcac aggatgctga tagtgaaggt gaagaaggta aattttatac
    13201 atttaatcct cttgagataa ttgaagtttt gggtgaagaa gatggaattt tctttaataa
    13261 ttattttgat ataactagta gtggaaattt tgaaggcaaa agtattccta atcttataaa
    13321 aaataaagaa tatgagagac ataatgaaaa gatagctgac cttagtaaaa aggtatttga
    13381 atatagaaaa gaaagaacat ctttgcataa agatgacaag atacttacat catggaatgc
    13441 attgatgata gttgctttaa caaaggcata tagtacttta aaaaatgaca tatatttaga
    13501 gtattcaaat aagtgtctta actttataaa taataatctt gtaaatgagt caggtagatt
    13561 attagctaga tatagagatg gaagttccga ctatttagca tatttagatg attatgcttt
    13621 tttaatctgg gcgtatatag agctttatga gtcaacattt aatatgaaat atttagaaaa
    13681 ggctttaaat ttgaatgaaa gctgtatcaa ccttttttgg gattatgaaa aaagtggatt
    13741 ttatatatat ggtaaagata gtgaaaattt aatagcaaga ccaaaagatt tgtatgatgg
    13801 agctattcca tcaggaaatt ctgttcaatt atacaatctt ataagacttg cgaaaattac
    13861 tggagataat agacttgaag aaatgtcata taaacaatta aaactgtatg tggataatgt
    13921 aaagagttct ccaactggct acagctttta tatgctttca ttgatgtttg aactttattc
    13981 tactaaggaa attatatgta tttttaagga agattctgat ttaattgcat ttaaagaatt
    14041 gataagtgaa aattttatac caaatgcaac ttttttagca aagaaataca atgaagaaaa
    14101 cactat
//
LOCUS       DAEPID010000094        13887 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.094, whole genome shotgun sequence.
ACCESSION   DAEPID010000094 DAEPID010000000
VERSION     DAEPID010000094.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 13887)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 13887)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..13887
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.094"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            271..411
                     /locus_tag="KR257_003234"
     CDS             271..411
                     /locus_tag="KR257_003234"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419462.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0031904.1"
                     /translation="MGIIESASKLAEMVHLLAVEKGITDIEAWDEAVKEYSKIYEERR
                     NE"
     gene            complement(586..906)
                     /locus_tag="KR257_003235"
     CDS             complement(586..906)
                     /locus_tag="KR257_003235"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428248.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MazG-like family protein"
                     /protein_id="HBH0031905.1"
                     /translation="MKLKTISLPELNNLDPTLESTFIKMGEEQGELAECIGKFRNLSG
                     ENNDLDEVDIIKKTAKELMDVAQTCVTMMFKLEEQYGINLDEIRKEHIKKLEKRGYIK
                     NMDK"
     gene            complement(1026..1763)
                     /locus_tag="KR257_003236"
     CDS             complement(1026..1763)
                     /locus_tag="KR257_003236"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419464.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NAD-dependent protein deacylase"
                     /protein_id="HBH0031906.1"
                     /translation="MDANSLKDLIANHNNIVFFGGAGVSTESNIPDFRSSTGLFSQKL
                     NKQFTAEQLVSHTFFVRYPEEFFEFYKDKLIYPNAKPNNAHIALAKLEEMGKLKAVIT
                     QNIDGLHQMAGSKNVLELHGSVHRNYCTKCGKFFDLESMLNLGGNIPYCDNCGSIVKP
                     DVVLYEEALDSDVITKTISAISNADLLIIGGTSLAVYPAASFIDYYKGDYIALINKAN
                     TVYDKSASLVINKPIGEVLYEAVLRQI"
     gene            1978..3801
                     /gene="acd"
                     /locus_tag="KR257_003237"
     CDS             1978..3801
                     /gene="acd"
                     /locus_tag="KR257_003237"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861172.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="N-acetylglucosaminidase"
                     /protein_id="HBH0031907.1"
                     /translation="MKKKAALATLAMLPLGVVNAHADGDIGIVTINYLNVRNEPTAES
                     SIAFVAKKDDKVLIKDSSNGWYKIKAESGQEGWASSKYIAKSNSDSLRTSTNKEKQVI
                     SNSLNMRNGAGTSYRVITVLKKGQKVEVISESNGWSKIKYDGRLGYVSSSYLGDVSNS
                     TNKSKTKQVNTTSLNVRSGPNTSYGLLGKLPKGSKVEVISESNGWSKIKYNGKDAYVS
                     SMYLSDVSQSNSDNSSQSNDKKNTDKVVNTASLNVRSGPGSTYSKLGKVYKGSKVTVL
                     SESSGWAKINFNNKEAFVVGNYLSTSADTSNNNSNSNSDNSSNSNGNNSSSSGQVNGM
                     SGISGAKIDYKSLSYTLESHISKQVEKAASGGNVIAPSNRKSTPSPEFSTFSAQRTSS
                     FVNASSSDIEYYLNPKNFTNTTKGMMQFLKINSYRDGISESSLNSYLNGLSSSVFKNQ
                     GAAFINAAKKYNIDVVYLVSHAMWETAYGKSTLAQGQTLTSYKGQPLSKPVKVYNFFG
                     IGAIDKSANVSGAEAAYSNGWTSVEATIDGSAKWISQNYVNSSKYNQNTIYKMKWNYD
                     YTWHQYATDVNWANGISGIMENLIGLYGGGSSLVFEVPQYK"
     gene            4016..8314
                     /locus_tag="KR257_003238"
     CDS             4016..8314
                     /locus_tag="KR257_003238"
                     /EC_number="2.7.7.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419466.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PolC-type DNA polymerase III"
                     /protein_id="HBH0031908.1"
                     /translation="MESIKEYLDKLEINNSGLGKQLKEVYINRVVYFKEDKIVYFYLT
                     SKDIVSHELLDKFKEELMYKLDYFKDMRMKIRFTGLERKSNKDVIKKYWNNILYILKY
                     LCPSIAGWYKQVEFLCLEEELKIKLPKGIFYERLMKKNVTYVLKTVLSEELGLDLNIT
                     IEKAVDEKVNKERLIRINDREMEEKIRALEIGKVNNCEENEEESYVIKSDVDENLIYG
                     DNANAMIENIVELNASSGTVAVVGDIFDVDTKELKNGKILMIASITDYTSSISCKLFL
                     TDTNKDGVLENVKKGAYLKIKGDIVYDTYQREISMMISGIRKETRIEREDKSEEKRVE
                     LHAHTQMSSMDAICSVKKLVERAAKWGHSAIAITDHGVVQGFPDAMNAGKSNNIKILY
                     GVEGYLVEDDSLIIEDANDKELSQTFVVFDIETTGFSNTNDKITEIGAVKIENFKIVD
                     RFSELINPEKDISYKIQELTGITNELIKDKPTIEEVLPKFMEFVGDSVLVAHNAEFDT
                     GFISQKCREQGLLYNNKKVDTLMLARVMLPNLKRHRLNVVAKELGIPLLNHHRAVDDA
                     EATALIFNKFLQMLTEKGAKTLSDVNNILGKIDYTKLSTNHITLIAKNSIGIKNLYKI
                     ISDAHVNHFFRAPRILRSVLNEYKEGLIIGSACEAGVVFQAVKKNVSDEEMKKIIDLY
                     DYIEVMPIDNNRFMIDKGEVKDEEELRELNRKLIDTAKKFDKIPVATGDVHFLDKHEA
                     VLRKVLKYSQGFKVDEEETYLHFRTTDEMLEEFSYLGEELAYEVVVENSNLIADMVED
                     IKPIPDDTYPPIIEGSDVELREMCYKKAKRIYGDPIPEIVQKRLDRELNSIISNGYAV
                     MYIIAQKLVAKSLSDGYLVGSRGSVGSSFAATMSDITEVNPLPAHYICENEDCKYSFF
                     YEIGEWGSGVDLPDKDCPKCGRKLAKNGHDIPFEVFLGFEGDKEPDIDLNFSGNYQPT
                     IHKYTEELFGEGYVYRAGTIGTVAEKTAFGYARKYVEENNISVPNAEVLRLSNGCTGV
                     KRTSGQHPGGVMVIPDYKDVYDFTPIQYPANDTSCGVITTHFDYHSISGRILKLDILG
                     HDGPTIIRMLEDMTGINITEIPLDDKETMSLFTSTEALGVTPEEINCPIGCLAVPEFG
                     TKFVRQMLLDTKPTTFAELVRISGLSHGTDVWVNNAQDLVREDIVGLKDVISTRDDIM
                     NYLIFKGLPPKMSFTIMESVRKGKGLKPEHIEEMKKNNVPEWYIGSCKKIKYMFPKAH
                     AVAYVMTSFRIAYCKVHYPEAFYATYFTTKVEDFDADLIVKGLDAIKSKINEIESLGN
                     DATTKEKGMLTVLEVALEMYARGIKLLPVDIYKSDATEFIVVGEKTLLPPMAAIQGLG
                     GNAAINIQNERKNGEFISKEDLRKRTKISKTVIETLTNHGSLENMSERNQLSLF"
     gene            8518..8979
                     /locus_tag="KR257_003239"
     CDS             8518..8979
                     /locus_tag="KR257_003239"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428240.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribosome maturation factor RimP"
                     /protein_id="HBH0031909.1"
                     /translation="MKKNLEATIEEIVTKITDEHGFEMVDVEYVKEAGEYYLRVYIDK
                     EEGISLNECELVSRELSPILDEKDPIKENYFLEVSSPGLDRALKKDRDFVRYQGRDVD
                     LKLYKPLNGCKQFEGELVGLTEDNNIKIIANGKEMEFNRKDVAIVRLAIKF"
     gene            9009..10163
                     /gene="nusA"
                     /locus_tag="KR257_003240"
     CDS             9009..10163
                     /gene="nusA"
                     /locus_tag="KR257_003240"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889093.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcription termination/antitermination
                     protein NusA"
                     /protein_id="HBH0031910.1"
                     /translation="MNHEFMEALDELVVDRGIDKEILIDTIEQALLTAYKKNFGSAQN
                     VRVEFDRDKGDIKVFSQRVVVDESDLYDTFLEIELADAREINPNYELGDIIEHEVTPK
                     NFGRIAAQTAKQVVVQRIREAEREIVYNEFIEKENEIVTGEVARANKNVVYVNLGRIE
                     GIMTQSEQIPFENYKAGQKIKFYILEVKKTNKGPQIVVSRSHPGLVKRLFEEEVPEIY
                     EGIVQIKSVAREAGSRTKMAVRSIDEKIDPIGACVGPKGLRVKNIVDELGDEKIDIIK
                     YSEDPAEFISAALSPSKVVRVDIDEDEKSALVIVPDYQLSLAIGKEGQNARLAAKLTN
                     WKIDIKSESQAEQEMLNLENSKEIEAEDVEAEFIDQEELDTSEDNFSEEE"
     gene            10170..10451
                     /locus_tag="KR257_003241"
     CDS             10170..10451
                     /locus_tag="KR257_003241"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428236.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YlxR family protein"
                     /protein_id="HBH0031911.1"
                     /translation="MILKKVKKVPQRKCIACQDRDSKKELIRIVKNKEGKIFLDPTGR
                     ANGRGAYVCKSSECLKKAIKSKALNKAFKIDVPDEVYDNLLMELEEYEK"
     gene            10441..10752
                     /locus_tag="KR257_003242"
     CDS             10441..10752
                     /locus_tag="KR257_003242"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419470.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribosomal L7Ae/L30e/S12e/Gadd45 family protein"
                     /protein_id="HBH0031912.1"
                     /translation="MKNNKEKVLSFLGLATRAGKIVSGDDSTLLDLKKGKVNLILIAE
                     DASNNTKKLFKDKSTFRNIPYLFFSTKEEIGFAIGKSPRAVVGIKDENFSKKIIELIE
                     I"
     gene            10774..12714
                     /gene="infB"
                     /locus_tag="KR257_003243"
     CDS             10774..12714
                     /gene="infB"
                     /locus_tag="KR257_003243"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438306.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="translation initiation factor IF-2"
                     /protein_id="HBH0031913.1"
                     /translation="MSKTRVYQIAEELNISNEELINKLAELDINVTDKDSVLEGEELE
                     LALEMLGEDLSQENGNVIEIDGKLTVQVLATKLDKSPSEIIMKLMKMGTMATINQEIS
                     FEIAALAAKDYGFELTVAESDDTEALEIEALMEIEEDKEEDLKPRPPVVTVMGHVDHG
                     KTSLLDAIRKTDVISGEAGGITQHIGASEVKINGHKIVFLDTPGHEAFTSMRARGAQV
                     TDIAILVVAADDGIMPQTVEAINHAKAAGVPLIVAINKIDKPGANPDKVKQELADQGL
                     LVEDWGGEVIAVPVSAKKKEGIDTLLEMVLLVAEMEELRANPNKRAVGTVIEAELDKG
                     RGPVATVLVQGGTLTVGDPIVAGVACGKVRAMINAKGKRVKTAGPSTAVEILGLSEVP
                     QGGDQFVEVPTDKIARSVAARRQQIVRDEMLKSTQRLSLDALFSQMSEGSIKDLNIVI
                     KADVQGSVQAVKQSLEKLSNEEVQVKVIHGGVGAVTESDILLAAASNAIIIGFNVRPV
                     PGAESLGEKENVDIRTYTIIYKAIEDIQAAMTGMLDPEYVDEETGKAEIREIYKISGV
                     GTVAGCYVTNGKIFRNCKVRLVRDSIIIHEGELAALKRFKDDVKEVNSGYECGMSFVN
                     YNDIKEGDIVEAYITKEVERKL"
     gene            12757..13137
                     /gene="rbfA"
                     /locus_tag="KR257_003244"
     CDS             12757..13137
                     /gene="rbfA"
                     /locus_tag="KR257_003244"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889095.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosome-binding factor RbfA"
                     /protein_id="HBH0031914.1"
                     /translation="MASYNRTRRIAEEIRKVVSTMLINGVKDPRITSMVSVTDVEVTN
                     DLRYAYVYVSILGGDEESTLTGLKSAGGYIRREVGKNIKLRYIPEIVFKLDDSIEKGM
                     YMDSLIKRVNEKNAQQNEDENYDE"
     gene            13118..13795
                     /locus_tag="KR257_003245"
                     /pseudo
     CDS             13118..13795
                     /locus_tag="KR257_003245"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438308.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="DHH family phosphoesterase"
BASE COUNT         5548 a         1575 c         2591 g         4173 t
ORIGIN      
        1 atataacatt ctctcctata ataaatttaa tatatatcta tataaatata ttcattatat
       61 ctcaatttaa tatataaaaa agataataat agttagattt tttatatgaa ttttaatagg
      121 taaaatatcc tattgttttg tagatatatc ctaattatgt caaaaaataa aaaaattttt
      181 atttattaga gtttttggaa ataataataa cagatattat aattaattaa cagtttttgt
      241 aagtatttga caatagagag ggtgtaacaa atgggaataa tagagtcagc atcaaaattg
      301 gctgagatgg ttcatttatt ggctgttgaa aaggggataa ctgatataga agcatgggat
      361 gaagctgtga aagaatacag caaaatttat gaagaaagaa gaaatgaata gaatgataaa
      421 aaatgaaaac ttgatgataa aaaataactt tatttaaaga aattcaattt ttatagaagt
      481 attaaaaata atataaataa aaagatggta tttcaaatgt aagtaaaaaa tcattttggg
      541 ataccatcct tattatttat tttaataata tataagtaat aaatcttact tatccatatt
      601 ttttatgtaa cctctttttt ctaacttttt tatatgctcc ttacgtattt catcaagatt
      661 aataccatat tgttcttcta gcttaaacat catagtaaca catgtctgcg ctacatccat
      721 tagttcctta gcagttttct ttataatatc aacttcatct aaatcattat tttctccact
      781 tagatttctg aatttaccta tacattcagc taattcacct tgttcttcac ccattttgat
      841 aaatgtagat tctagtgttg ggtctaaatt attaagctct ggtaaagata tagtttttag
      901 tttcataaaa gctcctttca agttattcgt atttatacta aaacatcata acaaaaataa
      961 tactaaaaaa aaactttaaa ttcaacataa aaacttacat atataataaa aatcatgaaa
     1021 taaatctata tttgtcttaa tacagcctca tataaaactt ctccaatagg tttatttatt
     1081 acaagagaag ctgacttatc atagactgta tttgctttat taataagagc aatataatca
     1141 cctttgtaat aatctataaa acttgctgct gggtacacag ctaatgatgt acctcctata
     1201 atcaataaat cagcattact tatagcagaa attgttttag taatgacatc actgtcaaga
     1261 gcttcctcat aaagtactac atctggtttt actatagaac cacagttgtc acagtaagga
     1321 atattacctc ccagatttaa catagattct aagtcaaaaa acttaccaca tttagtacaa
     1381 taatttctat gtacagaacc atgaagttct agcacatttt tacttccagc catttgatga
     1441 agtccatcaa tattttgagt tatgacagct ttaagcttac ccatttcttc gagttttgct
     1501 aaagctatat gagcattatt gggttttgca ttaggatata ttaatttatc cttataaaat
     1561 tcaaaaaatt cttctggata tctaacaaaa aaagtatgtg aaactaattg ttcagcagta
     1621 aattgtttat tgagtttttg gctaaataat ccagtagaac ttctaaagtc tggaatatta
     1681 gattcagttg aaacacctgc tccaccaaaa aatacaatat tattgtgatt agctattaag
     1741 tcttttaagc tatttgcatc catagttaca cctccaaatt attatatata aattgtacta
     1801 catattaggt cgtttatgtt ttattaattt aaataaatat atagtttaat aagttaaata
     1861 aagggaatat aaataaaatg tatacagagt ataaatagac aatatttact aaaataacaa
     1921 gttgtcgtat aattatatta aaattgtttt agtgtataag aagggcgggg gaagtacgtg
     1981 aagaaaaaag cagctttagc aacattggct atgttaccct taggtgtggt aaatgcacat
     2041 gctgatggag atataggtat agtgactata aattatttaa atgtaagaaa tgaaccaact
     2101 gccgaaagta gcatagcctt tgttgctaaa aaagatgata aagttttgat taaagactct
     2161 tctaatggat ggtataaaat aaaagctgaa tctggacaag aaggttgggc ttcatcaaaa
     2221 tatatagcaa aatcaaatag tgactcttta agaacgtcta caaataaaga aaaacaagtt
     2281 atttcaaata gtttaaatat gagaaatgga gcaggtacaa gttacagagt aataactgta
     2341 ctaaaaaaag gtcaaaaagt agaagtaata tcagagagta atggatggtc taaaatcaaa
     2401 tatgatggaa gactaggata tgtatctagc tcttatttag gagacgtttc aaactcaact
     2461 aataaatcaa aaactaaaca agtgaataca acttcactaa atgtaaggag tggaccaaat
     2521 acaagttatg gtttgttagg caagttgcca aaaggaagta aagtagaagt aatatcagaa
     2581 agtaatggat ggtccaaaat aaagtataat ggaaaagatg cctatgtatc tagtatgtac
     2641 ttatcggatg taagtcaaag taattcagac aattctagtc aaagcaatga taaaaagaat
     2701 actgataagg ttgtaaatac agcttcttta aatgtaagaa gtggaccagg ttctacatat
     2761 agtaagttgg gaaaagttta taaaggaagt aaagtaactg tactatcaga aagtagtgga
     2821 tgggctaaga ttaattttaa caataaagaa gcatttgtag taggcaatta tttatctacc
     2881 tcagcagata cttcaaataa taactcaaat agtaactctg ataacagttc taatagtaat
     2941 ggtaataatt cttcatcatc aggccaagta aatggtatgt caggtataag tggggctaaa
     3001 attgattata aatctttgag ttatacttta gaatctcata taagtaaaca agttgagaaa
     3061 gcagcatcag gaggaaatgt gatagctcca agtaatagga aaagtactcc aagtcctgag
     3121 tttagtactt tttcagctca aagaacaagc tcatttgtaa atgcaagttc aagtgatata
     3181 gaatattatt taaatcctaa gaattttaca aatactacta aaggtatgat gcagttttta
     3241 aagattaaca gttatagaga tggtatttca gaatcaagtc ttaactcgta tcttaatggt
     3301 ttatcttcta gtgtatttaa aaaccaggga gcagccttta taaatgctgc caagaagtat
     3361 aatatagatg ttgtatatct agtatctcat gctatgtggg aaactgctta tggtaagtct
     3421 acacttgccc aaggtcaaac attaacatct tataagggac aacctcttag taagccagtt
     3481 aaagtataca atttttttgg tataggagca atagataaaa gtgctaatgt ttcaggtgca
     3541 gaagcagcgt attccaatgg ctggactagt gtagaagcta caatagatgg ctctgcaaag
     3601 tggatatcac aaaattacgt aaatagttct aagtacaatc agaatactat ctacaagatg
     3661 aagtggaatt atgattatac atggcatcag tatgcaactg atgtaaactg ggctaatgga
     3721 atttctggaa ttatggaaaa tttaattggt ctttatggag gaggaagtag tttggttttt
     3781 gaagttcctc aatataagta atacataaat aaaaaatata gactatgggt agttttcatt
     3841 ttatttaaat tatctatagt ctttttgtat ataatttata atctgtaaat ttaatgttaa
     3901 caaaactttt atgttataat attaattcta agtaaatata agtgagtaat aggtagaaat
     3961 agataaaaag tggtaataat atatataaag ataattttga gaaaggagga tatatatgga
     4021 aagtattaag gaatatttgg ataagttaga aattaataat agtggtcttg gaaagcaact
     4081 taaagaagtt tatataaata gagtagttta ttttaaggaa gataagatag tttattttta
     4141 tctaacttct aaagatattg tttctcatga acttttagat aaatttaaag aagaattgat
     4201 gtataaactc gattatttta aagatatgag gatgaagata agatttactg gtcttgaaag
     4261 aaaatccaat aaagatgtta taaaaaaata ttggaataat atattgtata tattaaagta
     4321 tctttgtcca tctattgcag ggtggtataa acaagtagaa tttctttgtt tagaagaaga
     4381 attaaaaata aaacttccaa aaggtatatt ttatgagcga ttaatgaaaa aaaatgtaac
     4441 ttatgtactt aaaaccgtgc ttagcgaaga gttgggatta gatttaaata taacaataga
     4501 aaaagctgtt gatgaaaagg taaataaaga aagactcata agaatcaatg atagagaaat
     4561 ggaagaaaaa attagggctt tagaaattgg aaaagttaat aactgtgaag aaaatgaaga
     4621 ggaaagctat gtcattaagt ctgatgtaga tgaaaattta atctatggag ataatgcaaa
     4681 tgctatgatt gaaaatatag ttgaattaaa tgcatcttct ggaacagttg cagttgttgg
     4741 agatatattt gatgttgaca ctaaagaact taaaaacgga aaaatactta tgatagcttc
     4801 aattacagat tatactagct caataagctg taaacttttt ttaacagata caaataagga
     4861 tggagtactt gaaaatgtta aaaaaggagc atacttaaaa atcaagggtg acatagttta
     4921 tgatacatat caaagagaaa ttagtatgat gattagtggg ataagaaaag aaactagaat
     4981 agagagagaa gataaatcag aggaaaaaag agtagaactc catgcacata cacaaatgtc
     5041 ttctatggat gctatttgtt ctgttaaaaa gcttgtagag cgtgcagcca aatggggtca
     5101 ttctgctatt gctataacag accatggtgt tgtacaagga tttccagatg ctatgaatgc
     5161 aggtaagtca aataatataa aaatacttta tggagtagaa gggtacctgg ttgaagatga
     5221 ttctctcatt atagaggatg caaatgataa agaactttcg cagacatttg ttgtatttga
     5281 catagagaca actggctttt ctaatacaaa tgataaaata actgagattg gtgctgtaaa
     5341 aatagaaaac tttaagattg tagatagatt tagtgagtta ataaatcctg aaaaagatat
     5401 ttcttataag atacaggaat tgacaggaat aactaatgaa ttaattaaag acaagccaac
     5461 cattgaagaa gttcttccta agtttatgga atttgttgga gatagtgtat tagtagcaca
     5521 taatgcagag tttgatactg gatttatatc gcaaaaatgt agggaacaag gcttgttata
     5581 taataacaaa aaagtagata cacttatgtt agcaagagta atgttgccaa acttaaaaag
     5641 acatagatta aatgtcgttg caaaagaact tggtattcct cttttaaatc accatagagc
     5701 agtggatgat gctgaagcta cagcacttat atttaataag tttttgcaga tgcttacaga
     5761 aaaaggtgca aaaactctaa gtgatgtaaa caatatactt ggaaagattg attacacaaa
     5821 gcttagcaca aatcatataa ccttgatagc aaaaaattct ataggtataa aaaatttata
     5881 taaaataatt tcagatgcac atgtaaatca tttttttaga gcaccaagaa tccttagaag
     5941 tgtattaaat gaatataaag aaggattaat aattggttcg gcttgtgaag ctggggtggt
     6001 ttttcaagct gtaaagaaaa acgtgtctga tgaggaaatg aaaaaaataa tagatttata
     6061 cgattatatt gaagtaatgc ctatagataa taatagattt atgattgata aaggagaagt
     6121 aaaggacgaa gaagagttaa gggagttgaa taggaaacta attgatacag ccaaaaaatt
     6181 tgacaaaatt ccagtagcta ctggggatgt tcatttttta gacaaacatg aagctgtctt
     6241 aagaaaagtt cttaaatatt ctcaaggttt taaagtagat gaagaagaaa cttatttaca
     6301 ttttagaaca acagatgaaa tgttggaaga gtttagttat cttggagaag aattggcata
     6361 tgaagttgta gttgaaaata gtaatctgat tgccgatatg gttgaagata taaaacctat
     6421 accagatgat acttatcctc caattataga gggctcagat gtggagttaa gagaaatgtg
     6481 ttacaaaaaa gccaaacgaa tctatggaga cccaatacca gaaatagttc aaaaaagact
     6541 ggatagagaa ttaaattcaa taataagcaa tgggtatgca gttatgtata ttatagctca
     6601 aaaactggtt gcaaaatctc tttcagatgg atatttagtt ggttcaagag gctcagttgg
     6661 ctcatctttt gcagctacta tgagtgatat aacagaagtt aatcctcttc cagcacatta
     6721 tatttgtgaa aacgaagact gtaaatattc attcttttat gaaataggtg aatggggctc
     6781 aggtgttgat ttaccagaca aggattgtcc aaagtgtgga agaaaacttg ctaaaaacgg
     6841 tcatgatatt ccatttgagg ttttcttagg ttttgaaggt gataaggaac cagatataga
     6901 cttaaatttc tcaggaaatt atcagccaac aattcataaa tacacagaag aactatttgg
     6961 agaggggtat gtatataggg ctgggactat aggtactgta gcagaaaaaa cagcttttgg
     7021 atacgcaaga aaatatgtgg aagaaaataa tataagtgta ccaaatgcag aagtacttag
     7081 gctttcaaat ggatgtactg gagtaaaaag aacctcagga caacatcctg gtggagttat
     7141 ggttatacca gactataaag atgtatacga ttttacacct atacagtatc cagcaaatga
     7201 tacttcttgt ggtgttataa ctactcactt tgattatcat tcaataagtg gtagaatact
     7261 taaacttgat atacttggac acgacggtcc taccattata aggatgcttg aagatatgac
     7321 tggaataaat ataacagaaa ttcctttaga tgataaagag actatgtctc tatttacatc
     7381 tacagaagca ttaggtgtta caccagaaga aataaactgt cctataggtt gccttgctgt
     7441 accagagttt ggaactaagt ttgtacgaca aatgttactt gacacaaaac ctactacatt
     7501 tgcagaactt gtacgtatat ctggtctctc tcatgggaca gatgtttggg taaataatgc
     7561 acaagactta gttagagaag atatagttgg attaaaagat gttatatcta cacgagatga
     7621 cataatgaac tatttaatat ttaaaggatt acctcccaaa atgagcttta caataatgga
     7681 gagtgtaaga aaaggtaaag gtttaaaacc agaacacatt gaagaaatga aaaaaaataa
     7741 tgttccagaa tggtatatag gctcatgtaa aaagattaag tacatgttcc caaaagcaca
     7801 tgctgttgct tatgtaatga catcatttag aattgcatat tgtaaagttc actatccaga
     7861 agcattttat gcgacttatt ttacgacaaa agttgaggat tttgatgcag atttaattgt
     7921 taaaggatta gatgctataa aatcaaaaat aaatgaaatt gagtcactgg gaaatgatgc
     7981 aaccacaaaa gaaaaaggta tgttgaccgt tttagaagtt gctcttgaaa tgtatgctag
     8041 aggaataaaa ttattaccag ttgatatata taaatcagat gcaactgagt ttatagttgt
     8101 aggagaaaaa acattacttc caccaatggc agcaatacaa ggtcttggag gaaatgcggc
     8161 tataaacatc caaaatgaaa gaaaaaatgg tgaatttata tcaaaagaag atttgagaaa
     8221 gagaacaaaa atatcaaaaa cggtaataga aactcttact aatcatggtt cacttgagaa
     8281 tatgagtgag agaaatcaat tgtcattgtt ttaagttagc ccaaaaagtt gcaaataaaa
     8341 gaattttatg atatcatagt atagaaaata gtatactttg cagaaactaa gagtgagaca
     8401 gctgttctca ctcttttatt ttaaatatat tattaaaaag ctggtttatt tttattaaat
     8461 atattttatt taagattata taaactggtc atttacaatt gaataggagg aactttaatg
     8521 aaaaaaaatt tagaagctac aattgaggag attgtaacta aaataacgga tgaacatgga
     8581 tttgaaatgg ttgatgttga atatgtaaaa gaagcaggag aatactactt aagagtatac
     8641 atagataaag aagaaggaat atctttaaat gaatgtgaat tagttagtag agaattaagt
     8701 ccaatactag atgaaaaaga ccctataaaa gaaaattact ttttagaggt atcttctcca
     8761 gggcttgata gagcattaaa aaaagacaga gattttgtta gatatcaagg tagagatgta
     8821 gatttaaaat tatataaacc attaaatgga tgtaagcaat ttgaaggtga acttgtagga
     8881 ttaacagaag ataataatat aaaaatcatt gcaaatggta aggaaatgga atttaataga
     8941 aaagatgttg ctattgtcag attagcaata aagttttagt ggtatattaa atagggagga
     9001 tataaaaaat gaatcatgaa tttatggaag cattagatga attagtagtt gacagaggta
     9061 tagataaaga aatacttata gatactatag aacaagctct tttaactgca tacaagaaaa
     9121 actttggttc agcacaaaat gttagagttg aatttgatag agacaaggga gatataaaag
     9181 tattttctca aagagttgtt gttgatgaat cagatttata tgatactttc ttagaaatag
     9241 agttagcaga tgctagagag ataaatccta attatgaatt aggtgatatt atagaacatg
     9301 aagttacacc taaaaacttt ggaagaattg cagctcaaac agcaaagcaa gtagttgttc
     9361 aaagaataag ggaagctgag agagaaatag tgtataatga atttatagaa aaagaaaatg
     9421 aaatagttac aggagaggtt gctagagcaa ataaaaatgt tgtttatgta aatcttggaa
     9481 gaatagaagg tataatgact caaagtgaac aaataccatt tgagaattat aaagcaggtc
     9541 aaaaaataaa attctatata cttgaagtta aaaagactaa caaaggacct caaatagttg
     9601 tatcaagaag tcatccgggt ctagtaaaga gattgtttga agaagaagtt cctgaaatat
     9661 atgaaggaat agttcaaata aaatctgtag caagagaagc agggtcaaga actaaaatgg
     9721 cagtaagatc tatagatgaa aaaatagacc caattggagc ttgtgttgga ccaaaaggac
     9781 ttagagtaaa aaatatagtg gatgaacttg gcgatgagaa aatagatata ataaaatata
     9841 gtgaagaccc agcagagttt atatcagcag cacttagccc atcaaaggtt gttagagtag
     9901 atatagatga agatgaaaag tctgccttag taatcgttcc agattatcag ttatcgcttg
     9961 ctataggtaa agaaggtcaa aatgcaagac tagcagcaaa attgactaac tggaaaatag
    10021 atattaagag cgaatctcaa gcagaacaag aaatgttaaa tcttgaaaat tccaaagaaa
    10081 tagaagctga ggatgttgaa gctgaattta tcgaccaaga agagttagat acttcagagg
    10141 ataattttag tgaagaagag taaggaggga tgattttgaa aaaagtaaaa aaagtgcctc
    10201 aaagaaaatg catagcatgt caagatagag actctaaaaa agagcttata agaatagtta
    10261 aaaataaaga aggaaaaata tttttagacc caacaggaag agccaatgga agaggagcat
    10321 atgtatgtaa aagctctgaa tgtctaaaaa aagctataaa gagtaaagca ttaaataaag
    10381 cttttaaaat agatgttcct gatgaagtct atgataatct acttatggag ttagaagaat
    10441 atgaaaaata ataaagaaaa agtactttcg ttcttagggc tcgcaactcg tgcagggaaa
    10501 atagtgtctg gtgatgattc aactttgctt gaccttaaaa aaggaaaagt aaatttgatt
    10561 ttaatcgcag aagatgcatc aaataatact aaaaaacttt ttaaagataa atcaactttt
    10621 agaaatattc catatctatt tttttcaaca aaagaggaaa taggatttgc aataggaaaa
    10681 tctccaagag cagttgtagg aataaaagat gaaaattttt ctaaaaagat aattgaacta
    10741 atagaaattt aaaataaaat agggggtgat cttgtgtcaa aaacaagagt ataccaaata
    10801 gcagaagaat taaatatatc aaatgaagag cttataaata agttagctga attagatata
    10861 aatgtaactg acaaagattc agtattagaa ggtgaagagt tagaattagc acttgaaatg
    10921 ttaggtgaag atttatctca agaaaatgga aatgttatag aaatagatgg aaagttgaca
    10981 gtacaagtat tagcaacgaa attagataaa tctccatcag aaataattat gaagcttatg
    11041 aaaatgggaa ctatggcaac aataaatcaa gagataagtt ttgagattgc tgctttggct
    11101 gccaaagact atggatttga attaacagta gctgaaagtg atgatacaga agctttagaa
    11161 atagaagctt taatggaaat tgaagaagac aaagaagagg atttaaaacc tagaccacca
    11221 gttgttacag ttatgggaca tgttgaccat ggtaagacat ctttactaga tgcaataaga
    11281 aaaactgatg tgatctcagg tgaagctgga ggaataactc agcatatagg tgcttcagaa
    11341 gttaaaatca atggacacaa aatagtattt ttagatactc caggacatga ggctttcaca
    11401 tcaatgagag caagaggagc acaagttaca gatatagcaa tattagtagt tgcagcagat
    11461 gatggtataa tgcctcaaac agttgaagct ataaaccatg ctaaagcagc aggtgtacct
    11521 ttaatagttg ctattaataa aatagataaa ccaggtgcaa acccagataa ggttaaacag
    11581 gaattagcag accaaggatt attagttgaa gactggggtg gagaagtaat agcagttcca
    11641 gtatcagcta agaaaaaaga aggaatagat acacttttag aaatggtatt attggttgct
    11701 gaaatggaag agttaagagc taatccaaat aaaagagcag taggaactgt tatagaagct
    11761 gagcttgata aaggaagagg gccagttgca acagtacttg ttcaaggtgg tactttaaca
    11821 gtaggtgacc caatcgttgc aggtgttgca tgtggtaaag ttagagcaat gataaatgca
    11881 aaaggtaaga gagtaaaaac agcaggacca tctacagcag tcgagatatt aggtctatca
    11941 gaagttccac aaggaggaga ccaatttgtc gaagttccaa ctgataagat tgctagaagt
    12001 gtagcagcaa gaagacaaca aatagttaga gatgaaatgt taaaatcaac tcaaagatta
    12061 tcactagatg ctctatttag tcaaatgagt gaaggttcta taaaagacct taatatagtt
    12121 ataaaagcag atgtacaagg ttcagtacag gcagttaaac aatctttaga aaaattatca
    12181 aatgaagaag ttcaagttaa agtaatacat ggtggtgttg gagctgtaac agaatcagac
    12241 atattacttg cagcagcttc taacgcaata ataataggat tcaatgtaag accagttcca
    12301 ggtgcagaat ctctaggaga aaaagaaaat gttgatataa gaacatatac tataatatac
    12361 aaggcaatag aagatataca agcggctatg actggtatgt tagaccctga atatgttgat
    12421 gaagaaacag gaaaagctga aataagagaa atatataaaa tatctggtgt tggaacagta
    12481 gctggatgtt atgtgactaa tggtaagata tttagaaatt gtaaagtaag attagttaga
    12541 gatagcataa taatacatga aggtgagctt gcagcactta agagatttaa agatgatgta
    12601 aaagaagtta attctggata cgaatgtggt atgagttttg taaattataa cgacataaaa
    12661 gaaggcgata tagtagaagc ttatataact aaagaagtag aaagaaaatt ataaattcgt
    12721 atcaaagaaa atcagttagt aaagaaggtc gatggtatgg catcatataa tagaacaaga
    12781 aggatagcag aagaaataag aaaagtcgta agtactatgc ttataaatgg agtaaaagac
    12841 cctagaataa catctatggt gagtgtaact gatgtagaag ttacaaatga cctaagatat
    12901 gcttatgtat atgtaagtat tctaggcgga gatgaagaat ccacactaac aggtcttaaa
    12961 agtgctggag gatatataag aagagaagta ggaaaaaata taaaacttag atatattcct
    13021 gagatagtat ttaaacttga tgattcaata gaaaaaggaa tgtatatgga tagccttata
    13081 aaaagagtta atgaaaaaaa tgctcaacaa aatgaggatg aaaattatga tgaataatat
    13141 ggatagtatt ataaactata tttatgaggg tgactatttt atagttacct ctcatatcag
    13201 tccagatgga gacaatattg gttctacact ttcaatgtat tatacattga agaatttagg
    13261 aaaaaatgta tattatgtac ttgatgatga agctccatta aatttaaggt ttttggttga
    13321 aggtgtaaaa atctataagt ctaatgaatt taatatgaag aactattctc taattgcact
    13381 tgattgtggg gataagatga gaatatgtgt gagtgatgaa atcaaaaata atgcatcaaa
    13441 attaatctgt attgaccatc atgctagtaa tgattcatat ggagatttaa attatgtaga
    13501 tattgatgca tcttctacat gtgaattagt ttataattta ttagttagat ttcagcaaat
    13561 aaaagatatt aatattataa atgaagatat agcaacatgt ttatatacag gtcttgtaac
    13621 tgatactgga aacttttcgt attcaaatgt acatgcaagt agctttgaaa tggcaaaaaa
    13681 tttacttgtt ttaggtgcac aaaaaaatac tataatacaa aatatatatc aaagcaattc
    13741 ttctggttat tacaaattat taggagaagc tctaaagggt ttggagatat ttgattaaaa
    13801 aatagttacg cacactcgtg actttagtca tgagttagta gctaaaatag tcagcatata
    13861 gggaaactta tatgtagaga taggata
//
LOCUS       DAEPID010000095        13392 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.095, whole genome shotgun sequence.
ACCESSION   DAEPID010000095 DAEPID010000000
VERSION     DAEPID010000095.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 13392)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 13392)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..13392
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.095"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            13..246
                     /locus_tag="KR257_003246"
     CDS             13..246
                     /locus_tag="KR257_003246"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896624.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0031915.1"
                     /translation="MAQVRKLNRILTIEECKIDDFLEMGYDLIDETGKVVRYGKSLNV
                     KDLIAENNILRSKVESLEEENKQLKEKNKLTKK"
     gene            256..657
                     /locus_tag="KR257_003247"
     CDS             256..657
                     /locus_tag="KR257_003247"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888836.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0031916.1"
                     /translation="MGNNIIDDIEKRLESFGYILKDGDKWLIDFVREKIENIIKLDCN
                     IKTMPIELKEIEADMIVGEFLFTKKNMGQLDIESINFEAVEKSISEGDTKVDFAIGSG
                     SQTPEQRFDSLIAYLTAYGKNKILTFRCLRW"
     gene            651..998
                     /locus_tag="KR257_003248"
     CDS             651..998
                     /locus_tag="KR257_003248"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015984843.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0031917.1"
                     /translation="MVSKTRKAIEMLYRYKCTIVEYQPIKDPVTKRTNNKEVIVLENQ
                     PCKLSYKNIVSATEGKLAKLEQTIKLFISPDIEIKAGSKLIINDKEYVRSGESAIYPN
                     HQEIILELFKDKA"
     gene            998..1423
                     /locus_tag="KR257_003249"
     CDS             998..1423
                     /locus_tag="KR257_003249"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896626.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HK97 gp10 family phage protein"
                     /protein_id="HBH0031918.1"
                     /translation="MARWGSVDFREFKRVCKKMEKLTKIDLDKFCKDAARELAARLLG
                     KVIRRTPVDTGFLRQGWNGVAYARSLPVYKQGNNYIIEVVNPTEYASYVNFGHRTKDG
                     KGWVKGQHFLTISEMELQSQVDKIIEKKLLILLKGVFDA"
     gene            1416..1853
                     /locus_tag="KR257_003250"
     CDS             1416..1853
                     /locus_tag="KR257_003250"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728452.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0031919.1"
                     /translation="MLNNIIDGISVKLDKSFGEKYTIYSEDVEQGINEPCFFIVPLNP
                     SKTPYPSGRELKKNSFDVHYFPRSEAKNFEINEIAEMLLEELEYIEINGDLVRGTNMN
                     FEIIDNVLHFFVDYNYFTIKSNNADKMNTVELFGGLKRGDNFE"
     gene            1846..2022
                     /locus_tag="KR257_003251"
     CDS             1846..2022
                     /locus_tag="KR257_003251"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728451.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0031920.1"
                     /translation="MSKTLSKGTDYKFTKEQIVNSKKYVNRKDLLNAILKENELYSFS
                     EVEDRINKFMKGVS"
     gene            2023..3333
                     /locus_tag="KR257_003252"
     CDS             2023..3333
                     /locus_tag="KR257_003252"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728450.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phage tail sheath family protein"
                     /protein_id="HBH0031921.1"
                     /translation="MALGGGTFVTQNKVLPGSYINFVSATRATSSLSDRGIVAMPLEL
                     DWGIDEEVFQVTSDDFEKYSTKYFGYDYTHEKLKGLRDLFKNIRLGYFYKLNKGVKAS
                     CSIATARCSGIRGNDLKVIVTTNIDDNAKFDVVTLLDNKKVDTQIAKVITELQDNDYV
                     TWKKEATLEATAGLTFTNGTNGEAVTGTEYQAFLDKIESYSFNALGCLATTAEIKSLF
                     VEFTKRMRDKVGAKFQTVLYKKNDADYEGVVSVENKIKDTGLLESSLIYWTTGAIAGC
                     DINKSNTNKRYDGEFDVDVNYTQIHLEEALKTGKFIFHKVGDEVHVLEDINTFVSFTD
                     EKNDDFSSNQSVRVLDQIANDIATLFNTKYLGEVPNDKSGRISFWNDVVKHHEQLQNM
                     RAIEDFKADDVSVEPGSDKKTVVVSDAVKVISAMSKLYMTVSVS"
     gene            3355..3825
                     /locus_tag="KR257_003253"
     CDS             3355..3825
                     /locus_tag="KR257_003253"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728449.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phage tail tube protein"
                     /protein_id="HBH0031922.1"
                     /translation="MAQQIKARDTISASKAECFVTIKGKRYNFMQAINLEAKMEKNKS
                     EIPILGSTTKGNKSTGSKYSGNATFYYNTSIFRELLYEYKETGEDIYFDIQITNEDPT
                     SSVGRQTIILEDCNMDSGIIAKFDADGEYLDEDMDFTFENWKLVEKFNIANGME"
     gene            3878..4135
                     /locus_tag="KR257_003254"
     CDS             3878..4135
                     /locus_tag="KR257_003254"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009901462.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0031923.1"
                     /translation="MIKIKDKYEIKDSISFDYSNKRPLEERVSEMYKKAGKYLIDISD
                     KLATDTIDGSSLKPIIIKFEINEAGVATIEKQTKYLVMEVE"
     gene            4140..4580
                     /locus_tag="KR257_003255"
     CDS             4140..4580
                     /locus_tag="KR257_003255"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009901463.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phage portal protein"
                     /protein_id="HBH0031924.1"
                     /translation="MGDLNAFLSQNAIKVENRKYVASERFIGEDGKAIEWELKAIDSD
                     RDRQLRKDSTIRVPVLNKKGKATGQYTSETDFNTYTLKLCVETVVFPDLHDAELQNSY
                     GVMGAEELLTTMLTPGEYTDLSSEVGEVNGFDRTFEDKVEEAKN"
     gene            4901..5062
                     /locus_tag="KR257_003256"
     CDS             4901..5062
                     /locus_tag="KR257_003256"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429855.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0031925.1"
                     /translation="MDNFLLSILASLIASLIGYIVCRCIKNVKSHSTRGKSKSGWELG
                     FKIKFRKFK"
     gene            5211..5444
                     /locus_tag="KR257_003257"
     CDS             5211..5444
                     /locus_tag="KR257_003257"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0031926.1"
                     /translation="MNKDIELTEKDLYCIARHIQVYVFKKDDEVIKKEDNPCCRCKHK
                     FKYYENSVCIYHCSVFQKLSKITGLKMGFGVKL"
     gene            5504..6031
                     /locus_tag="KR257_003258"
     CDS             5504..6031
                     /locus_tag="KR257_003258"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888847.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4352 domain-containing protein"
                     /protein_id="HBH0031927.1"
                     /translation="MREGKRRRGCLFWFIIIIIFSGVVGAIAGNSTNNGSTEKQKEDL
                     TKYIGEEGNIGDLKLTVNSISKASEIPVASGYLAYTPDSGKYGIINLTIKNQTKESQS
                     FMLNSFTLIGPDNSKYVPSLLIDVGNKYITMDTVNPNLDVTGNIAFEIPKDLLVSDCK
                     LKYSGSEQEFILKEK"
     gene            6173..6733
                     /locus_tag="KR257_003259"
     CDS             6173..6733
                     /locus_tag="KR257_003259"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009901472.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="zinc ribbon domain-containing protein"
                     /protein_id="HBH0031928.1"
                     /translation="MFCSNCGAEITGIGKFCSSCGVAVETEIIEDNNIKSNDLIVDAN
                     GIEINMTEIYRKYRKEKVNAIKNVMEISGLNIKEAKKIVDFSFEELKINFIDDTMSNS
                     EKEKIIQNQNRKNNIEKAQQESVACCPKCGSTSLTAQKKGFGIGKAMVGASLTGGIGL
                     VAGNLGAKKVRVTCLNCGKQFWAGKK"
     gene            6811..9099
                     /locus_tag="KR257_003260"
     CDS             6811..9099
                     /locus_tag="KR257_003260"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009901478.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tape measure protein"
                     /protein_id="HBH0031929.1"
                     /translation="MATIQTSIRIFDGMTPAFRHMTTAMNIVLSSFEQLQRTSSNAVN
                     ANSIIRAREELARAEAGFDRLERQIRESDNQQRKLNEDINKGASSTDRLVGSAKKLAA
                     TYLGIRTLGGLGNLSDQMTSTNARLGMINDGQQSDAGLNKMIFQSAERSRASYLDTAQ
                     IVSRIGMNAGKAFSSTKEIVGFAEQLNKKFVIAGASTEEMNSALLQLTQGLSSGVLRG
                     EELNAVFESAPNIIQSIADYLDVDIGKIRGMASEGMLTADIVKNSLLAAAEQTNAEFE
                     KMPYTFSQIWTSIKNNAIMIFGVIQKKIEQSMSSKGFRTFIDNFINSLYVLGNVAYNI
                     FNEIISILGSPFFQAFVNAIIVGVSLIVQALGWIITQALNIANVFAQNWSIIAPIVLG
                     VAAAMLVYNNALLLSIANKVKDIALSAKSLVMSFAHIVAESYRAAALVATTIAQDGLN
                     AAMAACPITWILYGIIAIVVAFFVAIAIFNHFAGTSVSAIGVVAGAISVAASFIGNLF
                     IATGNLIIDIVALIYNTLAGFAEFFANFLDDPIGSVIRAVSGMANAVLGIIRSIASAF
                     DTVFGSNLADAVSGWQDKLQGWTDKVAGEAKIKVERMDPNKLHFDRFNYGKAWDAGYK
                     WGDKLETNIKDKFDISKMAEDAKKKLGLDDLWDKKYGLGDGFGSAGLNSPLNDAAKGA
                     KDTAGNTAKMAKTMDKSQEDLKYLRDIAEQETINRFTGVNIKIDMNNTNNISKDNDLD
                     GIVNVLTEKLNDAMAVSAEGIV"
     gene            9116..9817
                     /locus_tag="KR257_003261"
     CDS             9116..9817
                     /locus_tag="KR257_003261"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009901468.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LysM peptidoglycan-binding domain-containing
                     protein"
                     /protein_id="HBH0031930.1"
                     /translation="MAYDFYLDGVQLPIAPPKLEVKVTNKNKTVDLINVGEVNILKKE
                     GLSEISFEAEFTHNKLPFYRGTFRDVQFFLSKLELLKTDCKPFQFIVSRELGNKVLFN
                     TNIKVSLEEYAISEDADNGSDTKVAIKLKQYRDYSTKKLVPATPEKTNYGRTPPPVMK
                     PKEFRPDSSNKPNGKTYTVKAGDSLWAICQKQLGNGSLYKKVYELNKTMMDKANKGKK
                     LSKYTIYKGQVLRLV"
     gene            9810..11780
                     /locus_tag="KR257_003262"
     CDS             9810..11780
                     /locus_tag="KR257_003262"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018112718.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="C40 family peptidase"
                     /protein_id="HBH0031931.1"
                     /translation="MSDDLVLANDRDIRLVIAHWEDFYEPVVLDGITWEIERRGTPSK
                     LEFTIVMDDILEFCEGNSVRLYYKGVGIFYGYIFQKKRDKENHIKIVAYDQLRYFKNK
                     DTYVYSNKTASELVKMLAKDFKLKYNVIEDTKYKISRVEENKTLFDMVLTALDDTLRE
                     KKEMYVLYDDFGRITLKNVASMKLDTVMNNDVIEDFDYNSSIDSDTYTKIKLVRDNEE
                     TGKRDVYIAQDSTHMRSWGILQLFDTVDKNMSEAEIKQKCDILLKLYNKKTKSLSLKN
                     VLGDIRVRAGCLVPVFLSLGDIDLQNYMLVEKVKHTFENNSHFMDLTLVDGDEFASYS
                     SSSYSSGNTNNKNEKQNGPAQSTTSKEDTDMANKINKLLKGKLSNTGNIFVKYSNAYK
                     VNPALMAAISMHESARGTSNIANTKNNFFGMKKNGDYMSFSSVDEGIKRGISNLSRNY
                     IHIGRKTLESIRNKYSSSSDKEWVKCVGAFYKQITGSTYNSNSAGTGVGSNEEAEKNL
                     KDLTYQVQNNNSNTSTNNNNKVSKVIQEAKNQLGKPYKWGGNGPKSFDCSGLMVWAFK
                     RGAGINLKRVSADQSKDSRGKLLCNINDVKAGDLVFFAYNKGKGNVHHVGLYIGNDQY
                     IHAPQTGDVVKISSLSGRQKKKHDFARARRFF"
     gene            11794..12054
                     /locus_tag="KR257_003263"
     CDS             11794..12054
                     /locus_tag="KR257_003263"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009901352.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF2577 domain-containing protein"
                     /protein_id="HBH0031932.1"
                     /translation="MSQELLQIIKKAAMDAVETSNPMQIAFGTIESVNPLIVKIEQKA
                     SFEEFFLIQTETFKRYTDKKIGDKLVLIRMQGGQQYLILDRM"
     gene            12059..12478
                     /locus_tag="KR257_003264"
     CDS             12059..12478
                     /locus_tag="KR257_003264"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009901339.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF2634 domain-containing protein"
                     /protein_id="HBH0031933.1"
                     /translation="MLPTDNIDYDIEDVSIINFDVRQEPSKTFKLNIEKNRVDGICDD
                     VEALKQTIFLILNTERYEHLIYSRNYGVELNDLIGEPISYVIPELERRITEALIQDDR
                     IENIDNFEFQNIKGKVQCRFSVHTKYGNIKAEKVVSV"
     gene            12491..>13392
                     /locus_tag="KR257_003265"
     CDS             12491..>13392
                     /locus_tag="KR257_003265"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015984854.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="baseplate J/gp47 family protein"
                     /protein_id="HBH0031934.1"
                     /translation="MTFENIIKRMLDSVPDTFDKREGSIIYNALAPVAIELTETYIAM
                     DELLDQTFVDTASYYYLEKRCKERGITPLEATNTIAKGVFNIDIPIDSRFNLGEYNYV
                     AIERISEGIYKMKCETAGPIFELGQLIPIEYIDKLETAELTEILINGEDEESEDSLRQ
                     RYYDSLNSQSFGGNMQNYKDEVNKIQDVGGVKVYPVWDGGGTVKLVIINSNFKVPSED
                     LVNLVQEEIDPIGHQGQGLGLAPIGHKVTVTGVVSTTINISAEITYKNGYTWENIKSI
                     AEEAIDDYLNELNMSWEDEENLIVR"
BASE COUNT         5330 a         1453 c         2672 g         3937 t
ORIGIN      
        1 agctggagca taatggcaca agtaaggaaa ttaaatagaa tattaaccat agaagagtgt
       61 aaaatagatg atttcttaga gatgggatat gatttgatag atgaaactgg taaggtagta
      121 aggtatggca agtcattaaa tgtaaaagat ttaatagctg aaaataatat tttaaggtca
      181 aaagttgagt ctttagaaga agaaaataag cagcttaaag agaaaaataa acttactaaa
      241 aagtaggtga aaattatggg aaataatata attgatgata tagaaaaaag acttgaaagt
      301 tttggatata tattaaaaga tggggataag tggttaatag attttgtaag agaaaaaata
      361 gaaaatatta ttaaactaga ttgtaatata aaaactatgc caattgaatt gaaagaaatt
      421 gaagctgata tgatagttgg agagttctta tttaccaaga aaaatatggg gcaattagat
      481 atagaaagca ttaactttga agctgtagaa aagtctatat cagaaggtga tacaaaggta
      541 gatttcgcta taggaagtgg ctctcaaaca ccagaacaac gctttgatag cttaatagct
      601 tatcttactg cttatggtaa gaataagata ttaaccttta ggtgcttaag atggtaagta
      661 aaactagaaa agcaatagaa atgttatata gatataaatg tactatagtt gagtatcagc
      721 caatcaaaga ccctgtaaca aaacgaacta acaataaaga agtgattgta ttagaaaatc
      781 aaccatgcaa gctttcatat aaaaatatag tttctgctac agaaggaaaa ttagctaagc
      841 tagagcaaac tattaaactc tttatatctc cagatataga aattaaagca ggttcaaaac
      901 ttattataaa tgataaagag tatgtaagaa gtggagaatc agctatatat ccaaatcatc
      961 aagaaataat acttgagtta tttaaggata aagcataatg gctagatggg gcagtgttga
     1021 ttttagagag tttaaaagag tttgtaaaaa gatggagaag cttacaaaga ttgatttaga
     1081 taagttttgc aaagatgcag caagagaatt agcagcaaga ctcttaggaa aagtaattag
     1141 aaggacacca gttgatacag gattcttaag acaaggatgg aatggagtgg cttatgctag
     1201 gtcgcttcct gtgtataaac aaggaaataa ttatattata gaggttgtta atccgactga
     1261 atatgcaagt tatgtaaatt tcgggcatag aactaaagac ggaaaaggtt gggttaaagg
     1321 acaacatttc ttaacaattt cagagatgga actacaaagc caagttgata agattataga
     1381 gaaaaagtta ttaatattac ttaaaggagt atttgatgct taataatatt atagatggaa
     1441 tatcagtaaa gttagataaa tcatttggag aaaaatatac aatttatagt gaggatgtag
     1501 agcaaggtat taatgaacct tgttttttta ttgttccttt aaatccaagc aagacaccat
     1561 atccaagcgg gagagaatta aagaaaaatt cttttgatgt acattatttc cctcgttcag
     1621 aagctaagaa ttttgaaata aatgagatag ctgagatgtt actggaagaa ttagagtata
     1681 tagaaatcaa tggagattta gttagaggca caaatatgaa ttttgaaatt atagacaatg
     1741 ttcttcactt ctttgttgat tataactact tcactataaa gagtaataat gcagataaaa
     1801 tgaatacagt agagttattc ggtggtttga agagaggtga taattttgag taagacatta
     1861 agcaaaggaa ccgattacaa gtttactaag gagcagatag ttaattctaa gaagtatgta
     1921 aatagaaaag acttattaaa tgcaatttta aaagaaaatg agttatattc cttctcagaa
     1981 gtagaggata gaataaataa attcatgaaa ggagtgagtt agatggcttt aggtggagga
     2041 acatttgtaa cacagaataa agtattacca ggtagctata taaactttgt aagtgccaca
     2101 agggcaacca gttcacttag cgatagaggt attgttgcaa tgcctttaga acttgattgg
     2161 ggaattgatg aagaagtatt tcaagtgact agtgatgatt ttgagaagta ttcaactaag
     2221 tattttggat atgattatac acatgagaag ttgaaaggtt tgagagattt atttaaaaat
     2281 ataaggctag gatatttcta taaattaaat aaaggtgtta aagctagttg tagtattgct
     2341 acagctagat gcagtggtat aagaggtaat gacttaaaag ttatagtaac aacaaatata
     2401 gatgataatg ctaaatttga tgttgtaaca cttttagata ataagaaagt tgatactcaa
     2461 atagctaaag ttattacaga actgcaagat aatgattatg tcacttggaa gaaggaagca
     2521 acattagagg ctacagcagg attaactttt actaatggaa ctaatggtga agctgtgaca
     2581 ggaacagagt atcaagcttt tcttgataag atagaaagtt actcatttaa tgcactagga
     2641 tgtttggcta caacagcaga gattaaaagt ttgtttgtag agtttactaa gagaatgaga
     2701 gacaaagttg gggctaagtt tcaaactgta ttatataaaa agaatgatgc agattatgaa
     2761 ggtgtagtat ctgttgaaaa taagattaaa gatactggat tattagaatc tagcttaatt
     2821 tactggacta ctggagctat agcaggatgc gatataaata aatctaatac taacaagcga
     2881 tatgatggtg aatttgatgt agatgttaat tacactcaaa tacatttaga agaagcttta
     2941 aaaactggta agtttatatt tcataaggtt ggagatgaag ttcatgtatt agaggatata
     3001 aatacttttg ttagttttac agatgaaaag aatgacgact tttcaagtaa tcaaagtgtt
     3061 agagtacttg accagattgc taatgatata gcgactttat ttaatacaaa gtacttgggt
     3121 gaagtaccaa atgataaatc tggtcgtatc tcgttttgga atgatgtagt taagcatcat
     3181 gaacaactgc aaaatatgag agcaatagaa gatttcaaag ctgatgatgt ttctgtagaa
     3241 cctggaagcg acaagaagac tgttgtagta agtgatgctg taaaagttat tagtgctatg
     3301 agtaagcttt atatgactgt ttcagttagt taacaataag aaaggagaat aataatggca
     3361 caacaaataa aagcaagaga tacaataagt gcatctaagg cagagtgttt tgtaactata
     3421 aaaggtaaaa gatataattt tatgcaagct attaacttag aagctaaaat ggaaaagaat
     3481 aagagtgaga tacctatatt aggtagtact acaaaaggaa ataaatcaac aggaagtaaa
     3541 tattcaggaa atgcaacatt ttattataat acctctatat ttagagaatt gttgtatgag
     3601 tataaagaaa ctggtgagga tatttacttc gatatacaaa ttaccaatga agacccaaca
     3661 agttcagtgg gtcgtcaaac tataatactg gaagattgca atatggactc aggcataatt
     3721 gctaaatttg atgctgatgg ggagtattta gatgaagata tggattttac ttttgagaat
     3781 tggaaattag ttgagaaatt taatatagca aatggtatgg agtaaaatac acatttatga
     3841 tttatgtatg tgtatttttt atttataaga ataggagatg attaaaatta aggataaata
     3901 tgagataaaa gattcaattt cttttgatta tagcaataaa agacctttgg aagaacgtgt
     3961 cagcgagatg tataaaaagg caggaaaata tcttatagat atttcagata agttagcaac
     4021 agatacaatt gatggttcgt cattaaagcc aataatcata aaatttgaaa taaatgaagc
     4081 tggtgttgca acaatagaaa aacaaacaaa atatttggtg atggaggtag aataagaata
     4141 tgggagattt aaacgctttt ttaagtcaaa atgcaataaa agtagagaat agaaagtatg
     4201 tggcaagtga aaggtttata ggagaagatg gaaaagcaat cgaatgggaa cttaaagcaa
     4261 tagattcaga tagagataga caattaagaa aagattcaac tataagagta cctgtactaa
     4321 ataaaaaagg gaaagcaaca gggcaataca ctagtgaaac agattttaat acttatactt
     4381 tgaaactgtg tgtagaaact gtagtatttc cagatttaca tgatgcagaa cttcaaaata
     4441 gctatggtgt aatgggagca gaggaactat taacaacaat gttaactcct ggtgaataca
     4501 cagacctttc aagtgaggta ggagaagtga atggttttga taggactttt gaagataaag
     4561 tagaagaagc aaaaaactaa ttgaaggagg cgattatgat gctagtgtag ctcattattg
     4621 ccttcataaa ttcaaatgga aaccacatga atatacagat ttaccagact tcgagagggc
     4681 atttgttgct gcttctatag atattaaagt agaagaagaa ataaaagaag aaaaaaagat
     4741 tgctaaagaa gctagaagaa gtagaagaag ataaaatata ggtaaaatat gtaagaatta
     4801 tatgttataa taattgtagc aagaagatgt aatctacaat ttatagagtg gagttcatac
     4861 tgggataaaa cctacttcct aatgaaagga ggtgggaagt atggacaatt ttttacttag
     4921 tatattagct agcttgatag ctagtttaat tggatatatc gtttgtagat gtatcaaaaa
     4981 cgtaaaaagc cactctactc gtggcaagag taaaagtggc tgggaacttg gttttaaaat
     5041 aaagttccgc aaatttaaat aatttatatt ttttaaaatt atgaacttca ctctaccgct
     5101 aaatagattg tagttcttct tgcctttatt ataccacaaa ttagaaaaaa tatgcaaagt
     5161 acttgtttta atagtaagta ctttttttat gtgaaaaaga aggtgattga atgaataaag
     5221 atatagaact tacagaaaaa gatttatatt gtattgctag acatattcaa gtgtatgtgt
     5281 ttaaaaaaga tgatgaggtc ataaaaaagg aagataatcc atgttgcaga tgcaagcata
     5341 aatttaagta ttatgagaat agtgtatgta tctatcattg ttcagtattt cagaagttat
     5401 ctaaaattac aggtcttaaa atgggttttg gagtcaaact ataatgtaaa aattttgaat
     5461 atatagtata atattcttat aaaatataat ttagggggat attatgagag aaggaaagag
     5521 aagaagagga tgtctatttt ggtttatcat tattattata ttttctgggg ttgttggagc
     5581 aatagcaggg aacagtacta ataatggaag cactgaaaaa caaaaagaag atttaactaa
     5641 atatattggt gaagaaggta atataggaga tttaaaatta actgttaata gtatttcaaa
     5701 agctagtgaa ataccagtag cttctggtta tttggcgtac actccagata gtggcaaata
     5761 tggtattata aatttaacaa taaaaaatca aactaaggaa agccaatctt ttatgctaaa
     5821 ttcattcaca ttaataggac cagataattc aaaatatgtt ccatctttat tgattgatgt
     5881 aggaaataaa tatataacta tggatactgt aaatcctaat ttagatgtaa caggtaatat
     5941 tgcatttgaa attcctaagg atttactagt ttctgattgt aaactaaaat atagtggttc
     6001 agagcaagaa tttatattaa aagaaaaata atatatagat ttaaaatcaa aaatactaaa
     6061 aacacttact aatgtaggtg tttttttaat gaaaggatgt gatgataatg taaaaatttt
     6121 actaatatag tataatattc ttataaaatt attatactgg gggggaaatg ttatgttttg
     6181 ttcaaattgt ggtgcagaaa tcacaggcat aggcaagttt tgttcaagtt gtggggttgc
     6241 tgtagaaact gaaattattg aagataataa tattaaatca aatgacttaa tcgttgatgc
     6301 taatggaata gaaataaata tgactgaaat ttatagaaaa tatagaaaag aaaaagtaaa
     6361 cgcaataaaa aatgtaatgg aaataagtgg tttgaatata aaggaagcaa aaaaaatagt
     6421 ggatttttct tttgaagaat taaaaattaa ttttattgat gatactatga gtaattcaga
     6481 aaaggaaaaa ataatacaaa atcaaaatag aaaaaataat attgaaaaag ctcaacaaga
     6541 atcagttgct tgttgcccta agtgtggttc aacatccttg acagctcaaa aaaaaggttt
     6601 tggtataggg aaagcaatgg taggagctag tctaactggt ggtataggtt tagtagctgg
     6661 aaatttagga gcaaagaaag ttagagttac atgcttgaat tgtgggaagc agttttgggc
     6721 aggcaaaaaa tagatgtatt aattataaaa acacttacta atttagtaag tgtttttatt
     6781 atctaaatta acagaaagga gagtgaaaaa atggctacaa tacagacatc aattcgcata
     6841 tttgatggaa tgacacctgc gtttcggcat atgacaactg ctatgaacat agtactgagt
     6901 tcatttgagc aattacaaag aacttctagt aatgcagtaa atgctaatag cataataaga
     6961 gctagagaag aactagcaag agcagaagct ggatttgata gattagaacg acaaataaga
     7021 gaatcagata atcaacagcg aaaacttaat gaggatataa ataagggtgc aagttctaca
     7081 gatagattag ttggaagtgc aaagaagcta gcagcaactt atttaggtat aagaacatta
     7141 ggaggtctag gaaatttaag cgaccagatg acaagtacta atgcgagact tggcatgata
     7201 aatgatgggc aacaatcaga tgctggactt aataaaatga tatttcaatc agctgaaagg
     7261 tcaagagcat cttacttaga tactgcacaa atagtgagtc gtataggcat gaacgcagga
     7321 aaggcgttta gcagtacaaa agaaattgta ggttttgcag agcaattaaa caaaaaattt
     7381 gtaatagcag gcgcaagtac tgaggaaatg aactcggcat tgttacagct aacccaaggg
     7441 ttgagttctg gcgtattaag aggtgaggaa ctgaatgctg tgtttgagtc agcacctaac
     7501 atcatccaat cgattgcaga ttatttggac gtggacatag gaaaaataag aggaatggca
     7561 tcagagggaa tgttaacagc agatattgta aaaaactcat tacttgcagc agcagagcag
     7621 accaatgcag agtttgaaaa aatgccttac acattttctc aaatttggac ttcaattaaa
     7681 aataatgcaa tcatgatatt tggtgttata cagaaaaaaa ttgaacagtc tatgtctagt
     7741 aagggatttc gaacctttat agataatttt ataaactctt tgtatgtact tggaaatgtt
     7801 gcttataaca tttttaatga aattataagt atattaggga gcccgttttt tcaagcattt
     7861 gtaaatgcga ttattgtagg tgttagttta atagtgcagg cactaggttg gataataaca
     7921 caggcattaa atattgctaa tgtgtttgct cagaactgga gtattattgc accaatagta
     7981 cttggagttg cggctgctat gttagtgtat aacaatgcgt tattacttag tattgcgaat
     8041 aaagttaaag atattgcact atctgccaaa tctttagtca tgagctttgc acatatagta
     8101 gcagagtctt atagagcagc agctttagta gcaactacaa tagcacaaga cggattaaat
     8161 gcagcaatgg cagcttgtcc tattacttgg attttatatg gaattatagc tatagttgtt
     8221 gcattttttg tagctatagc aatatttaat cacttcgcag gcactagtgt atctgctata
     8281 ggtgtagttg caggtgcaat atcagttgca gcctctttca taggaaactt atttattgca
     8341 acaggaaatt taattataga tattgtagct ttaatataca atactttagc aggctttgca
     8401 gagttctttg ctaatttttt agacgaccca attggctctg ttataagagc agtatccgga
     8461 atggctaatg ctgtattagg cattataaga agtatcgcaa gtgcatttga taccgtgttt
     8521 ggttcaaact tggcagatgc agtaagtgga tggcaagata aattgcaagg ttggactgat
     8581 aaagtagcag gagaagctaa aataaaagtc gaaagaatgg accctaataa actgcatttt
     8641 gacagattta attatggaaa agcatgggac gcaggatata aatggggaga taagttagaa
     8701 actaatataa aagataaatt tgatattagc aaaatggcag aagatgcaaa gaaaaaatta
     8761 ggattggatg atttatggga taaaaaatat ggattaggag atggatttgg ttcagcagga
     8821 ttaaactctc ctctcaatga tgcagcaaaa ggagcaaaag acactgcggg aaatacagca
     8881 aagatggcta aaacaatgga taaaagccaa gaagacttaa aatacttaag agacatagca
     8941 gaacaggaaa caatcaatag atttacagga gtaaacataa aaattgatat gaacaacaca
     9001 aacaacataa gtaaagataa tgacttagat ggaatagtta atgttctaac tgaaaagtta
     9061 aatgatgcaa tggctgtttc agccgaagga atagtttagg aaggagagtg agaaaatggc
     9121 ttatgatttt tacctagatg gagtacaact accaatcgca ccaccaaagc ttgaagtcaa
     9181 agtgacaaat aaaaacaaga cagttgattt aataaatgtt ggagaagtaa atatattaaa
     9241 aaaagaagga ttatctgaaa taagttttga agcagaattt acacataata aactaccatt
     9301 ttatcgtgga acttttaggg atgttcaatt ctttttaagt aaactggaac tactaaaaac
     9361 tgattgtaag ccatttcaat ttattgtatc gagggaatta ggtaataaag tactatttaa
     9421 cactaatata aaagtatctc ttgaagagta tgctatttca gaagatgcag ataatggctc
     9481 agatacaaaa gttgcaataa aattaaaaca atatagagat tactcaacta aaaagttagt
     9541 tcctgcaact cctgaaaaga caaactatgg taggactccc cctccagtca tgaaaccaaa
     9601 agaatttaga ccagattcat ccaataagcc aaatggtaaa acatatacag taaaagcagg
     9661 ggattctctt tgggcaattt gtcaaaagca attaggaaat ggttcgttat acaagaaagt
     9721 atatgagtta aataaaacaa tgatggataa agctaacaag ggaaaaaaat taagtaaata
     9781 caccatctat aaagggcagg tgttgaggct tgtctgatga tttagttctg gcgaatgata
     9841 gagatataag gctagttatt gcacattggg aagatttcta cgaacctgta gttttggatg
     9901 gtatcacatg ggaaatagag agacgaggaa caccatctaa acttgaattt acaatagtca
     9961 tggatgatat attagagttt tgtgaaggta actctgtaag actatattac aaaggtgtag
    10021 gtatattcta tggatatata tttcagaaaa agagagataa agaaaatcat atcaagatag
    10081 ttgcttatga ccagctaaga tattttaaga ataaagatac ttatgtatat agtaataaaa
    10141 cagcaagtga acttgtaaag atgttggcta aggattttaa attaaaatac aatgtcatag
    10201 aagatacaaa atataaaata tcgagagttg aagaaaataa aacactcttt gatatggtct
    10261 taactgcact agatgatact ctaagagaga aaaaggaaat gtatgtttta tatgatgatt
    10321 ttggaagaat aacattaaag aatgttgctt ctatgaaact tgatacggtt atgaacaatg
    10381 atgtaattga ggactttgac tacaattctt ctattgatag tgatacttac acaaagatta
    10441 aacttgtgag agataatgaa gaaacaggaa aaagagatgt gtatattgct caagactcaa
    10501 cgcatatgag gagttgggga atactacaac tatttgatac agttgataaa aatatgagtg
    10561 aagcagagat aaaacaaaaa tgtgatatac tcctaaaact atataataag aaaactaagt
    10621 cattaagttt aaaaaatgtg ttaggagata ttagagtaag agcaggttgt ttagtacctg
    10681 tttttttgtc gttaggagat attgatttac aaaattatat gttagttgag aaagtaaaac
    10741 atacatttga aaataacagt cattttatgg acctaacttt ggttgatgga gacgaatttg
    10801 cttcttattc ttcatcaagt tatagtagtg gaaatactaa taataaaaat gagaaacaaa
    10861 atggtcctgc acaaagtact acaagtaaag aagatactga tatggctaat aagattaata
    10921 aactacttaa aggtaaatta tcaaatacag gaaatatatt tgttaaatat tcaaatgctt
    10981 ataaagttaa tccagcactc atggctgcta tatctatgca cgaatcagct agagggactt
    11041 caaatattgc aaatactaaa aataatttct ttggaatgaa aaaaaatgga gattacatga
    11101 gtttttctag tgtagacgaa ggaataaaaa gaggtataag taatttatca agaaactata
    11161 tccatatagg acgaaaaact ttagaaagca tcagaaataa atattcttct agttcagaca
    11221 aagaatgggt aaaatgtgta ggtgcatttt ataagcaaat aacaggaagt acttataatt
    11281 ctaatagtgc aggcacagga gttggaagta atgaagaagc agaaaagaat ttaaaagatt
    11341 taacttatca agttcaaaac aataattcta atacatcaac aaacaataat aataaagtaa
    11401 gtaaagttat tcaagaagca aaaaatcaac ttggcaagcc ttacaaatgg ggtggtaatg
    11461 gtccaaagag ttttgactgt agtggtctta tggtgtgggc atttaaaaga ggtgcaggaa
    11521 taaatctcaa aagagtttca gcagaccaat caaaagatag tagaggaaaa ctattatgta
    11581 acataaatga tgtaaaagct ggtgatttag tattctttgc atacaacaaa ggaaaaggaa
    11641 atgtacatca tgttggacta tatataggaa atgaccaata tattcatgct ccacaaactg
    11701 gtgacgtagt aaaaataagt agtttaagtg gtagacaaaa gaaaaagcat gattttgcaa
    11761 gagctagaag attcttttaa gtgaggtgat aaagtgtcac aagaattatt gcaaataatt
    11821 aagaaggctg caatggatgc agtagaaaca agcaatccaa tgcaaattgc atttggaact
    11881 atagaaagtg ttaatccttt gatagttaag atagaacaaa aagcatcttt tgaagaattt
    11941 tttctaatac aaacagagac ttttaaaaga tatacagata aaaaaatagg ggataaatta
    12001 gtcttaatta ggatgcaagg aggacagcaa tatttgattt tagataggat gtgatgaaat
    12061 gttaccaaca gataacattg actatgatat agaagatgta tcgataatta attttgatgt
    12121 tagacaagaa ccaagtaaga cgtttaaatt gaatatagag aaaaatagag tagatggtat
    12181 ttgtgatgat gtagaagcat taaaacaaac cattttttta attttaaata ctgaaaggta
    12241 tgagcacctt atttattcta gaaattatgg tgttgaatta aatgatttaa ttggagaacc
    12301 tatttcatat gtaatacccg aacttgaaag aaggataaca gaagcactaa ttcaagatga
    12361 taggattgaa aatatagata attttgagtt tcaaaatata aagggtaaag tacaatgtag
    12421 attttcagtt catacaaaat atggaaatat aaaagcagag aaggtggtga gtgtataatt
    12481 gtttgagtta atgacatttg aaaatataat taaaagaatg ttagatagtg taccagatac
    12541 ttttgataaa agggaaggtt ctataatata taatgctctt gctcctgttg ctatagaact
    12601 tacagaaaca tacattgcta tggatgaatt actagaccaa acattcgtag atactgctag
    12661 ttattattat ttagagaaga gatgtaaaga gagaggtatt acaccacttg aagccactaa
    12721 tacaattgca aaaggagttt ttaacataga tattcctatt gattctaggt ttaatctagg
    12781 agaatataac tatgtagcaa ttgagagaat atctgaaggt atatataaga tgaaatgtga
    12841 gactgcggga cctatttttg agttgggaca actaatacct atcgaatata tagacaaatt
    12901 agaaacagca gaactgacag aaatactgat aaatggagaa gatgaagaga gtgaggatag
    12961 tttaagacaa agatattatg atagcctaaa ttcacagagc tttggtggaa atatgcaaaa
    13021 ttataaagat gaagttaaca aaatacaaga tgttggagga gttaaggttt atcctgtgtg
    13081 ggacggtgga ggaactgtta agttagtaat aattaactct aatttcaaag taccatcaga
    13141 ggatttagtt aatttagtgc aagaagaaat tgacccaatt ggacatcaag gacaaggctt
    13201 aggattagca ccaatagggc ataaagttac tgttacaggt gttgtaagta caactataaa
    13261 tatatcagca gagataacat acaaaaatgg ctacacttgg gagaatataa aatcaattgc
    13321 agaagaagca atagacgact atttaaatga acttaacatg agttgggaag atgaagaaaa
    13381 cttaatagtc cg
//
LOCUS       DAEPID010000096        13176 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.096, whole genome shotgun sequence.
ACCESSION   DAEPID010000096 DAEPID010000000
VERSION     DAEPID010000096.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 13176)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 13176)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..13176
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.096"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            complement(451..1203)
                     /locus_tag="KR257_003266"
     CDS             complement(451..1203)
                     /locus_tag="KR257_003266"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861417.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TSUP family transporter"
                     /protein_id="HBH0031935.1"
                     /translation="MFSVIFLCIGGFLAAFVDSIAGGGGLISMPVLMAIGVPVHLAIG
                     TNKFAASAGCISSAYRYAKSGKINNNLLKKLVPFTIIGSVLGVRCVLSISEEILNVLV
                     VAMILIVAIYTFISKNLGQEDNFEAVNKKNLRLGMLMALIMGFYDGFFGPGTGTFLTF
                     GFIKIYGYDFLHASANTKILNLTSNITSLLLFMINGQVDYKIAIVFALVMIMGAYVGA
                     KVAIKKGSKMIKPIFLVMALFMVVKLVYQTLV"
     gene            complement(1262..2917)
                     /locus_tag="KR257_003267"
     CDS             complement(1262..2917)
                     /locus_tag="KR257_003267"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729413.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="HBH0031936.1"
                     /translation="MVDFIESNNEVQKFDWGEVMWIHEPSKTQFNRLSAGIVRFFPGN
                     CQEKHFHLSEEQLLYVIQGEGIQIIDGKKVNIKETSIVYCPPYSEHEIINTGKIDLVI
                     LITYVPHKFSSLRQIPIVFSENNIQELVNVNIIENLANQISNILKLRISVYDLKYKEI
                     FETKKENKFCDICKNIKPCTKKLVKSINNDNFEKVYHCEYGVSSLEIPIVLEENIVGY
                     IECGNFIVYKSIYIDKNLSELSSSSGIDIKYINKIYNEFPLNPKSRLYVLKENLLMMS
                     EFIQEIAKRNFFENQLSIKDEEILKSRKENIRLEEALKKANSRLLEEEYIINPIDMFN
                     NSSKEYPFELELYIEKEIKNMNLEGVYNLIDTNKLRYNDVRDTIQEMIFVLSRTVLRD
                     LEDLKLISYLRNKYNKKISLVNSDEDLWNVLFEFSKECIDKNRAFWRKDKGNLIENIN
                     EYIKKYYKENINLNSISDVFFISPNYLSSIFNERNKVSITEYINLLRIEESKKYLLDR
                     SMSVSDICKKVGFNNSSYFSQIFKKFNSITPNEYRKNMLDNKY"
     gene            complement(4189..5268)
                     /locus_tag="KR257_003268"
     CDS             complement(4189..5268)
                     /locus_tag="KR257_003268"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897145.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha/beta hydrolase"
                     /protein_id="HBH0031937.1"
                     /translation="MILITLCILVAVFVLAFAGLRLIAPTIIRTSHKIEAPGIDRMEM
                     VEIGGIQQALYIRGQNADNPIILWVHGGPGNSMMPFLHLYQYEWENDFTVVNWDQRNV
                     GKTYFANDPAAVLQTMSAERVLQDVHEVTAYLKQEFNKEKIILIGHSWGTVLGTMAVQ
                     TYPEDYSAYIGIAQTVNMVDNERVGYEKTLEMVKAAGKQKDIKALEAIAPYPPAKYGP
                     SYLAALMTVRTYQSKYGLSINMDLGNIISILATPYYSLRELKNTAIVNPNAIDNQGDV
                     LRFLVEEADIRNYGVDYQVPVYYIMGENDYNSPYLPAKKFFDEIVAPDKQIFFIPDAD
                     HLPFLSKKAEFDCVLLEEIAPKLAK"
     gene            complement(5352..6008)
                     /locus_tag="KR257_003269"
     CDS             complement(5352..6008)
                     /locus_tag="KR257_003269"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861420.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="HBH0031938.1"
                     /translation="MTRKNNPKQAIENIITISAKLFAEKGYDKTSMQNIVDASGMSKG
                     GIFHHFSSKEDIFNVVMERRFEQIIETVNQWLGEMHGLTAKEKLRSLVRRHLTDEVIK
                     ESSNMITSAIESPHIILAFTQDNLKKLAPILANVLREGIEDRSIITEFPDECAEVILL
                     LFNFWCDTDVFQGDFPTLRKRFQFLQFLMRQIGVDILEDEIIESINIFYERKPMGQVE
                     "
     gene            6330..6536
                     /locus_tag="KR257_003270"
     CDS             6330..6536
                     /locus_tag="KR257_003270"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435216.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0031939.1"
                     /translation="MISHAAEICKKYKMPFIIFPTIEKKSIEEWVNIGANMLCFAQDT
                     TFITYVINQLLSFYNEIVPIQKQH"
     gene            complement(6689..7117)
                     /locus_tag="KR257_003271"
     CDS             complement(6689..7117)
                     /locus_tag="KR257_003271"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018112846.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flavodoxin"
                     /protein_id="HBH0031940.1"
                     /translation="MSKIYIVYWSGTGNTEKMANFVAEGVKLKGKTPEVLDVSLLKPS
                     DLKEEDKFALGCPSMGAEQLEEGYMEPFVSELESMVSGKQIGLFGSYGWGNCEWMRDW
                     EERMQNAGATIIGGEGITAMEDPNEEAKDECIELGKTLAE"
     gene            complement(7593..8531)
                     /locus_tag="KR257_003272"
     CDS             complement(7593..8531)
                     /locus_tag="KR257_003272"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889978.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="S8 family peptidase"
                     /protein_id="HBH0031941.1"
                     /translation="MNKRMKLIPYEINENLRGAKNKFPYGIKQMNARGMWDEGYTGKN
                     IVVGIIDTGCDISHPLLKGKIIGGANFSDDSNGNKNIYEDFNGHGTHVAGIIAASNYN
                     NEVMGVAPDCKLLIAKALNKDGTGTYQSIINAINFAVNNKVDIISMSLGGNKDDKNLK
                     NAVMQAVKNNISVVCAAGNNGDGDSSTSEYSYPASYAEVIEVGAINENYLVEKFSNSN
                     TTIDLVAPGRNIISTYMDNKLAIMSGTSMSAPYVSGSLALIKEWAREEFERDLDEAEL
                     YAQLIKCTRALGIPRTEQGNGYLYLNLYKYKNNSKR"
     gene            complement(9045..9857)
                     /locus_tag="KR257_003273"
     CDS             complement(9045..9857)
                     /locus_tag="KR257_003273"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009905675.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha/beta hydrolase"
                     /protein_id="HBH0031942.1"
                     /translation="MFYNAKSCQMMIGSNTVNYIEFGSGKKTLIILPGLGDGLFPLHG
                     KIQAIAFAFRYKQFAKDYKVYVFSRKNQITEKYSTRDMAKDQADIMKKLGIMKAEVMG
                     VSQGGMIAQYLAIDYPELVEKLVLAVTSSKQNDTIQNVICSWIDMAKKQNYNDLMIDT
                     AKKSYSERYLKKYQLFIPFLGKVGKPKDFKRFIIQATSCIEHNAFSELNKITCPTLII
                     GGANDKIVGNNASFHLAEKIKKSEIFIYEGLGHATYEEAQDFNERVLEFLNK"
     gene            complement(9880..10512)
                     /locus_tag="KR257_003274"
     CDS             complement(9880..10512)
                     /locus_tag="KR257_003274"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428902.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="HBH0031943.1"
                     /translation="MNREEKSKNSKEKIIQSAFSLFSSKGYDSTSTQDIINLSGLSRG
                     AMYHHFKTKEDILRSVTKELYSQMNNFLEHLVADDTLTANEKIIELVVHSANDYTRRK
                     MVHCSWLEKIPFALIEEVRNLNNVVAPNIAKIIKQGVENKEFSCEYPEELAEMLVFSI
                     DILLDPVLFKREYSEVCNRLDFLLFMLKKMDIPLIDEYGIQKFKDLFRQL"
     gene            complement(10856..12511)
                     /gene="ilvD"
                     /locus_tag="KR257_003275"
     CDS             complement(10856..12511)
                     /gene="ilvD"
                     /locus_tag="KR257_003275"
                     /EC_number="4.2.1.9"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020457899.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dihydroxy-acid dehydratase"
                     /protein_id="HBH0031944.1"
                     /translation="MRSDIKKGIEGAPKRALMYGMGLTKEEIERPLIGIVNAQNEVIP
                     GHLHLDEIAEAAKNGVRMSGGLPLEFPAIGVCDGIAMGHVGMNYSLASRELIADSIEA
                     MAMAHGFDALVLIPNCDKIVPGMLMAAARLNIPSIVVSGGPMLPGKKNGKVYDFNSAM
                     EGVGACKDGTVSEEELEALAMNSCPGCGSCSGLFTANSMNCLTEALGMGIPYNGTAAS
                     HSGERKRIAKYAGMYVMELLKNDIKPRDILTIDAFKNAIAVDMAMAGSTNTVLHLPAI
                     AYESGIELNLNFFDEISEKTPCLTKLSPSGKHHIEDLHMAGGIPAIMNELSKINGINL
                     DCKTVTGKTIGENIRNCEIENEEVIHTLKNPYSNQGGLAILKGNLALNGAVVKKSAVA
                     EEMLVHEGPARVFNSEEEAVNAIFGKKINKGDVIVIRYEGPKGGPGMKEMLSPTSAVA
                     GMGLDKHVALLTDGRFSGATRGASIGHISPEAMEGGLIGLVEEGDIISINIPDKKLEL
                     KVDEVEIENRKLKFKPLEPKIKHGYLSRYAKLVTSANTGAVLK"
     gene            complement(12835..13134)
                     /locus_tag="KR257_003276"
     CDS             complement(12835..13134)
                     /locus_tag="KR257_003276"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428907.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0031945.1"
                     /translation="MKWIKWYSITCICIFIVVAFYMFIFPNKIETIDTSSAYSFVEKK
                     VPNSAVYQGYKKNPVDGTTTIYYSYDNSTHIVRLSHPEDYSRKINWDKVSNIRFD"
BASE COUNT         4220 a         2411 c         1443 g         5102 t
ORIGIN      
        1 attccattcc tgtataaaat ctaacttttg agtctcagta caatcttatt ttgagacaat
       61 cttttttgtt ttatattttc ttatatttaa aatataacgc atatcttatg caacatattc
      121 atatttttct ttatattctt tcatcgcatc attccaagcg tcttgtactg ttacacctct
      181 tttattagca attttttgtg ccagttcaat tatcttcata gctcttcttg atatgttcat
      241 aaacattcct cctacaaatt accatatatt tcatatatat aaatcaaggt tatattttta
      301 tgatatataa tccttctatt gtaagattac agtttatatg tgtattatat atgaactata
      361 ttagaagata attagaattt ttataaagct atatgattag attaaatata aaagctttac
      421 aattacttat aaatttaaaa agtctataaa ctaaactaat gtttgatata ccaattttac
      481 gaccataaat aatgccatta ctaaaaatat tggttttatc atctttgaac ctttctttat
      541 agcaacttta gcacctacat aagctcccat tatcatcact aatgcaaaca ctatagcaat
      601 tttataatct acttgaccat ttatcatgaa taataacaat gaagttatat tacttgttaa
      661 gtttaatatt tttgtatttg cagaagcatg taaaaaatca tatccatata tttttataaa
      721 tccaaaagtc aaaaaagttc ctgtacctgg accaaaaaaa ccatcataaa aacccattat
      781 aagagccata agcatcccta gtcttaaatt tttcttatta acagcttcaa aattatcttc
      841 ttgacctaaa tttttagaaa taaaggtgta aatagccact attaaaatca tagccacaac
      901 caaaacattt aatatctctt cacttattga taatacacat ctcacaccta gaacactacc
      961 aataatagta aatggtacta atttttttaa aaggttgtta ttaatttttc cagactttgc
     1021 atatctatag gcactactta tacatcctgc tgatgctgca aatttatttg taccaatggc
     1081 aagatgtact ggcactccaa ttgccataag aacaggcatg cttataagtc ctcctcctcc
     1141 tgctatagaa tctacaaaag cagctaaaaa cccccctata cataaaaaaa taactgaaaa
     1201 cataaaattc ctccatcatt ctctttcaat ttttcttaca atatatatta tataatctta
     1261 tttaatactt attatccagc atattctttc tatattcatt tggagttata ctattaaact
     1321 tcttaaatat ttgtgaaaaa taactactgt tattaaaacc tactttctta caaatatcac
     1381 taacactcat gcttctatct aacagatatt ttttagattc ttctatccta agaagattta
     1441 tatactcagt tattgaaact ttatttcttt cattaaaaat agaactcaaa taatttggac
     1501 ttataaaaaa aacatctgat atactattca aatttatatt ttctttataa tattttttta
     1561 tatattcgtt tatattttca attagatttc ctttatcttt tctccaaaat gctctattct
     1621 tatcaataca ctctttggaa aattcaaata atacattcca taaatcttca tcactgttta
     1681 caagtgatat ttttttatta tatttatttc ttaaataaga tataagtttt aaatcctcta
     1741 aatctctaag cactgttcta gacaatacaa atatcatttc ctgaatagta tctctaacat
     1801 cattatatct taatttgttt gtatctatta gattataaac accttctaaa ttcatatttt
     1861 taatttcttt ttcaatataa agttctaatt caaagggata ttcttttgaa gaattattga
     1921 acatatctat cggattaata atatactctt cttctaataa tctactattt gcttttttaa
     1981 gtgcctcttc aagtcttata ttttcttttc tactcttcaa tatctcctca tcttttatac
     2041 taagttgatt ttcaaaaaaa ttcctcttag ctatttcctg aataaattca gacatcatta
     2101 ataaattttc ttttaataca tataatctac ttttaggatt taatggaaat tcattgtaaa
     2161 ttttgtttat gtattttata tcaataccag aactacttga taattcagat aaatttttat
     2221 ctatataaat agacttatat actataaaat taccacattc tatatatcca actatatttt
     2281 cttctaatac tataggtatc tctaaactgg aaacaccata ctcacaatga tacacttttt
     2341 caaagttatc attatttatg cttttaacaa gttttttagt acacggtttt atatttttac
     2401 aaatatcgca aaatttattt tctttcttag tctcaaatat ttctttatac tttaagtcat
     2461 atacagatat tctaagcttc aatatattag atatttgatt tgcaagattt tcaattatgt
     2521 ttacattaac taactcctgt atattgtttt cagaaaatac tataggtatt tgtctcaaac
     2581 tcgaaaattt atgaggaaca taagtaatta atattactaa atcaatttta ccagtgttta
     2641 taatttcatg ttctgaatat ggtgggcaat aaactataga tgtttccttt atattgacct
     2701 ttttaccatc aattatttgt attccttctc cctgaatcac atataaaagc tgttcttcac
     2761 ttaaatgaaa atgcttttct tggcagtttc ccggaaaaaa tcttacaatt ccagcactaa
     2821 gtctattgaa ttgtgttttt gatggttcgt gtatccacat aacctctccc caatcaaatt
     2881 tttgtacttc attatttgac tcaataaaat ccaccataaa ctcacctcgt agtttttgtc
     2941 taaatatttt ttcttccctt cttatattaa aataatatca tcatcattaa ctttcattac
     3001 tataaaatca tcatactctt ttaatactcc tgtaatttta gttgcactta gtttactaca
     3061 attcagtttt ttaatatatt gataaattct ataattactt ttttattttg taaaatcagt
     3121 gttttcccaa aataattata tctataaatg aaagtatttt tactgcttac atcaatatat
     3181 gttatcataa ttttcctttt tattgcatat ataaataact gtatataaca ttgtccaata
     3241 ctatatagaa atacatctaa gaaagaatat tattaaattg ttccaattaa tattattttt
     3301 cttatagaaa taaaaaactg ttggattctt ttagaaaaat tattttttac ataccttttt
     3361 tgcttaaata gtctatcttc tcagctattt tgtatataca ctcttctagt tcatgatttt
     3421 attttaatat cttgcttata ttgctgaaat aattaaattc ttttatctat catattgtct
     3481 cttatatcac aaacatattg tttcttatat cacaaaaatg aaagcattct tatatcttca
     3541 atatataaac ctgctttttt taatcttgta ataaatatag gatactctat attctcttcc
     3601 tagaaataac taataccact tatttttcta tcatatagaa agtaataaat ctttttctta
     3661 ataaaattca atagtaagtg gaataaaatt ttatatgaat aagaacatta taaaaatact
     3721 ttatacaata gtcaataaaa gatattagct tcaaattgtg ttgaagttgt attatttaaa
     3781 gtggaaaagc aaataaaaaa gaaataatgg tataagtaga aaaatatact taaaacaagg
     3841 cgaagcctct cttgtatcta aatcaagtag agaattaaat ctaaaaaaga aaataaatat
     3901 aaaagatgac tcctgtacat tacaagaatc atcttatggt ttcataatca ctccatggtt
     3961 tttaactgtc tgatataaag gtctcagttc actcatagca tgaccacctt ttccgattgc
     4021 tgaccccgtc acttatggac aaaatgtcca taagtgatag tcctctctta aaaccctcta
     4081 aatagatata tctcaagcac ctcattgaaa ccagttgctg gaaacaaact gaagcgttct
     4141 ggaatagtaa aagaaattgc caccatatcc acgttactgt cctagttgtt actttgctaa
     4201 cttcggagcg atttcctcta acaatacgca gtcaaattct gcctttttgc taagaaatgg
     4261 cagatggtct gcatctggta taaaaaaaat ctgtttgtct ggcgccacta tttcatcaaa
     4321 aaatttcttc gctggaagat aggggctatt atagtcattt tctcccatga tgtagtatac
     4381 agggacctga tagtcaactc cataatttct tatgtcagct tcttccacta aaaaccgcaa
     4441 tacatcacct tgattgtcaa tcgcatttgg attgacaatg gccgtatttt ttaactctct
     4501 caatgaataa tatggggttg ccagtatact gattatattg cccaaatcca tatttataga
     4561 aagcccatac ttgctttggt atgttcttac tgtcataaga gctgccaaat agcttggacc
     4621 atattttgct ggcggatatg gtgcaatagc ttccagcgcc ttgatatctt tttgcttccc
     4681 tgcagctttc accatttcaa gtgtcttttc atagcccacg cgctcattgt ccaccatatt
     4741 aacagtctgc gcaatcccaa tgtacgcgct gtaatcctcc ggataggttt gcacagccat
     4801 agttcccagc actgttcccc agctatgacc tataaggata attttctcct tgttgaactc
     4861 ttgcttcaaa tatgctgtca cctcatggac gtcttgcaga acacgctccg cgctcatggt
     4921 ctgcaaaact gctgccggat cgttcgcaaa gtatgttttg cctacgtttc gctgatccca
     4981 gttcaccaca gtaaaatcat tttcccactc atactggtac agatgtaaaa atggcatcat
     5041 tgaattacca ggacccccat gaacccaaag gatgatgggg ttgtctgcgt tttgtccccg
     5101 gatatataac gcctgctgta tgccgccgat ctccaccatt tccatgcggt cgattccagg
     5161 agcttctatt ttatggcttg tacgtataat cgtgggggct atcagacgca aaccggcaaa
     5221 cgccagaaca aaaacagcaa ctagtatgca aagtgtgatt aatatcattt taagtacctt
     5281 ctttcatgaa tttttttagc catagatatc tcctctaaca ttaaaaaaag tatgttgcta
     5341 ttttagtttt gttactctac ctgtcccatt ggtttccttt cataaaaaat attaattgat
     5401 tctataatct catcttccag gatatcaact cctatttgtc tcataagaaa ctgtaagaat
     5461 tgaaaccgtt tacgaagtgt aggaaagtcc ccctgaaata catctgtatc acaccaaaag
     5521 ttaaagagca gcaaaattac ctctgcgcat tcatctggga actctgtgat gatgcttcta
     5581 tcctctatgc cttctcgtaa aacatttgct aatattggtg ctagtttttt caaattatcc
     5641 tgtgtaaatg ccagtatgat atgcggactt tctatcgcgc ttgtaatcat gttactagat
     5701 tcttttatca cctcatccgt taaatgccgc ctaactaaac ttctaagctt ctcttttgct
     5761 gtaagtccat gcatttcacc gagccattga tttactgtct ctattatctg ttcaaagcgc
     5821 ctttccatga ccacattaaa aatatcttct tttgaactga agtgatgaaa aattccgccc
     5881 tttgacattc ccgaagcatc aacaatattt tgcatacttg ttttgtcgta tcctttttca
     5941 gcaaacaact ttgcagaaat ggtaatgata ttttcaatag cttgctttgg attgttcttt
     6001 ctagtcatta tataactcct tcttattaaa aaccgactgt tggtttttat tatataagct
     6061 attcctgctt ctgtcaagta acattgtgtt tatggcaaaa caataaggtt tggtggttag
     6121 acaggtatta attagactaa tgcgactttc ccctagatgg aacccttggt aaatttgcaa
     6181 tctttaccgg ctttgattat atctgtaagc aaggcaggta tggccacgcc tgccctgttt
     6241 gaccctcgga tattcattcc tatccctcct ctccttagcc attacaccaa aacgccgctc
     6301 attgtctcca atggcggcgt tttaaagata tgatttctca tgctgctgaa atatgcaaaa
     6361 aatataagat gccctttatt atttttccta caatagaaaa gaaaagtatt gaagaatggg
     6421 ttaatattgg agcaaatatg ctttgttttg cacaagatac tacctttatc acttatgtta
     6481 tcaatcaatt attatctttt tataatgaga ttgtaccaat tcaaaaacaa cattaaatta
     6541 taaatctaat tttatattaa aagagactaa tattttatct atctctatta aggatatttt
     6601 cttatgtatc ataatattag tctctcttat tattatatac tgctatcatc attagttgtt
     6661 atttatacta tttttataat atacaaattt attcagctaa cgttttgcct aattctatac
     6721 actcatcttt tgcttcttca tttgggtctt ccattgctgt aattccttct ccaccaataa
     6781 ttgtagcacc agcattttgc atacgttctt cccagtctct catccattca caatttcccc
     6841 atccatatga accaaataat ccaatctgtt tacctgatac catagattct aattctgaaa
     6901 caaatggctc catatacccc tcttctagtt gctctgctcc catagatggg caacctaatg
     6961 caaatttatc ttcttctttt aaatcacttg gtttcagtaa gctcacatct aaaacttctg
     7021 gtgtcttacc ttttaacttc acaccttcag ccacaaaatt tgccattttt tcagtatttc
     7081 ctgttccact ccaataaaca atatatattt tactcatttt tacctcctgt agtatttttt
     7141 aattaatcaa tagttagtta tagctaacta acatctaaaa aacaaaagat ttctttatct
     7201 gaaatctctt tatttttcta aatatagaat atcatagttg atattgaaat tcaatactta
     7261 ttgataatat ttatcattta tattttatat tcattttata atatcaaaac actgtatcgt
     7321 atttctaatc tttcatagaa aaatttctaa cttatagtac ttttgcatct cttataaatc
     7381 ttttatatgt ataagtacat agaaaaacac accttttcca gatgtgctat ctataatatc
     7441 gtatatttat ttttcaattc taactagcta atatgtttat aaattttatc acttaatacc
     7501 tttatacatt gatgtaaaat cttacaccta agtaattttt attatttgtc tcgactctat
     7561 ataatatagc tattttatca tcaaatcaaa aattatcttt tactattatt cttgtattta
     7621 tagagattta aatataagta tccatttcct tgttccgttc taggtattcc aagcgctctc
     7681 gtacatttta ttaattgtgc atacagttca gcttcatcta aatctctttc aaactcctct
     7741 cttgcccatt ctttaattag tgctaatgag cctgatacgt atggtgcact catactagta
     7801 ccactcataa tagcaagttt attatccata taagttgata taatatttct tcctggagct
     7861 accaaatcta ttgtagtatt tgaattacta aacttttcaa ccaaatagtt ctcatttatt
     7921 gcacctactt ctattacctc agcataactg gctggataac tatactcact tgtactagaa
     7981 tcaccatctc cattattacc tgctgcacac actacagaaa tattattttt tactgcttgc
     8041 atgacagcat tttttaaatt cttatcatct ttgtttcccc caagagacat agatataata
     8101 tcaaccttgt tatttacagc aaagttaata gcattaatta tactttgata tgttccggta
     8161 ccatctttat ttaatgcttt tgctattaat aatttacaat ctggagctac tcccataact
     8221 tcattattat aattagatgc agctataata cccgccacat gagttccatg accattaaaa
     8281 tcctcatata tatttttatt tccattactg tcatcactaa aatttgcacc accaattatt
     8341 tttcctttta aaagaggatg agatatatca caacctgtat ctattatacc aactacaata
     8401 tttttaccag tataaccttc atcccacatt cccctagcat tcatttgttt tattccatat
     8461 gggaatttat tttttgcacc tcttagattt tcatttattt catatggaat tagtttcatt
     8521 cttttattca tcatatatcc tcctaaaaat tttattgctt ataaaaatca tgaattttat
     8581 tttataatag gtttataaat caaattaaaa cctatatcta cttatttata tttatgatat
     8641 attttttatt tttaggagtc atattttatt gtatataaaa taatatttag ataactatat
     8701 taaaaaatac atgtttgctt atatacaaaa cttactaaaa tatcttcaat atttttgtat
     8761 acaaacatta tattttttat ataaaaatct cataaaaatt ttgattatat tttcataagt
     8821 taacaaatgt gggtataata tgaatttaca aaattcctct gtttgtataa gtgctttacc
     8881 aatacactaa tatataatca cattgaagct atatttgtat ttatagtaga taatgtatca
     8941 aaaattggtt atgaatagta aaaataccag ttaagcatat tttcatgttt ctatttttaa
     9001 cattaaattt ccaatcttca tatgtatatt tttaacaaag gtgtttactt atttaaaaac
     9061 tctaaaactc tttcattaaa atcctgtgct tcttcatatg tagcgtgtcc caatccctca
     9121 tagataaata tttcgctttt tttaatcttt tctgctaaat gaaaagaagc attatttcca
     9181 acaattttat cattagcacc tcctataatt aaggttggac atgttatttt atttaattcg
     9241 gaaaaggcat tatgttctat gcaagaggtc gcttgaataa taaatcgttt aaaatccttt
     9301 ggtttaccta cttttcctaa aaaaggaata aataattggt atttttttaa atatctttca
     9361 gaataggatt tctttgctgt gtcaatcatt aaatcattgt aattctgctt cttcgccata
     9421 tcaatccaac tacaaataac attttggata gtatcatttt gctttgaaga agtaactgcc
     9481 aacacaagtt tctcaactaa ctcaggataa tcaattgcca gatattgagc tatcattcca
     9541 ccttgagaaa cacccattac ttctgctttc ataattccaa gttttttcat tatatctgct
     9601 tggtctttag ccatatccct tgtggaatat ttttctgtaa tttgattttt tctactaaat
     9661 acataaacct tataatcttt tgcaaattgc ttatatctaa aagcaaaagc aatcgcctgt
     9721 atttttccat gtaaaggaaa taaaccatct cctaatcctg gtaaaataat tagtgtcttc
     9781 ttaccactac caaattcaat ataattcact gtattacttc ctatcatcat ttgacaactt
     9841 tttgcattat aaaacatagt ctattcctcg cttttcctat tataattgtc taaataaatc
     9901 tttaaatttt tgaataccat actcatcaat tagaggaata tccatttttt ttaacatgaa
     9961 taataaaaaa tccaacctat tacatacttc actgtattca cgtttaaata atacagggtc
    10021 aagtaaaata tcaatactaa aaacgagcat ttcagctaat tcctctggat attcacaaga
    10081 aaattcttta ttttcaacac cttgtttaat tatcttagca atattgggtg caactacatt
    10141 gttgagatta cgaacttcct ctattaaagc gaatgggatt ttttctaacc agctacaatg
    10201 taccattttt ctacgtgtgt aatcattcgc actatgaaca accaattcta ttattttttc
    10261 atttgctgta agggtgtcat cagcaacaag atgctctaaa aaattattca tttgtgagta
    10321 aagttctttt gtgacacttc tcagtatatc ttctttagtt ttaaagtgat gatacattgc
    10381 acctctagat agaccagata aattgataat atcttgtgta gatgttgaat catatccttt
    10441 agacgaaaat agtgaaaatg ctgattggat aattttttct ttactatttt tacttttttc
    10501 ttctctattc atatttccct cctaaaaaca gactgtctgt ttgtttttta ttatacattt
    10561 taatatttat tatgtcaaga attaactgac tttcaatttc ttcatagttc agatggaacg
    10621 aaaagcattc cacatcaaac ttttaaaaag ttgtattacc tcaacaaggt ctaaaagata
    10681 catctctatg ctgtactcgt attccttata atagagatgt attgttttca aagataatca
    10741 agattttgct gtgtttttca tacaaaataa aaaggatacc tcattagtgc tataacacct
    10801 aagatatcca attaatattt tcttaacttt ttctaattta cataaatata gtctactatt
    10861 ttaaaactgc tcctgtattt gctgatgtta ccagtttagc atatctactt aagtatccat
    10921 gctttatttt cggttctaaa ggtttaaatt ttaattttct attttctatt tcaacttcat
    10981 ctacttttaa ctctaatttt ttgtctggta tgtttataga aattatatct ccttcttcaa
    11041 ctaacccgat taaaccacct tccatagctt ctggagaaat atggcctata gatgctcctc
    11101 tagttgctcc tgaaaaacga ccatcagtaa gaagtgctac atgcttatca agtcccattc
    11161 ctgcaactgc tgatgtagga gatagcattt ctttcattcc tggaccaccc tttggacctt
    11221 catatcttat aactataaca tcacctttgt ttattttttt accaaaaata gcatttacag
    11281 cttcttcttc tgaattaaaa actcttgctg gtccttcatg aactaacatt tcttctgcaa
    11341 ctgctgactt ttttacaaca gctccattta gagcaagatt tcctttcaat attgcaagcc
    11401 caccttggtt actatatgga ttctttaatg tatgtattac ttcttcattt tctatttcac
    11461 aatttcttat attttcccct atagtcttgc ctgttacggt tttgcaatct aaatttattc
    11521 catttatctt tgaaagttcg ttcattatag ctggtattcc tcctgccata tgtaaatctt
    11581 caatatgatg ttttccactt ggacttaatt ttgttaaaca aggagttttt tcacttattt
    11641 catcaaaaaa atttaagtta agctctattc ctgattcata agctattgca ggtaagtgaa
    11701 gtactgtatt tgtagaacca gccattgcca tatccacagc tatagcattt ttaaaagcat
    11761 ctattgttaa aatatctcta ggttttatgt cgttcttaag taactccata acatacatac
    11821 ctgcatattt tgctatcctt tttctttctc cagaatgtga cgcagcagta ccattatatg
    11881 gtatacccat gcctaaagct tctgttaaac aattcatgct atttgctgtg aaaagaccag
    11941 aacatgaacc acatccagga caagagttca tggctaacgc ttctaattct tcttcactta
    12001 ctgttccatc tttacatgct ccaacaccct ccattgcaga gttaaaatca tatacttttc
    12061 catttttttt acctggaagc ataggccctc cactcacaac aatacttggt atattaagtc
    12121 ttgcagcagc cattaacata cctggcacta tcttgtcaca attaggtata agtaccaaag
    12181 catcaaaacc atgtgccata gccatagctt ctattgaatc tgctattaat tctcttgaag
    12241 ccagggaata attcattcca acatgcccca tagctatacc atcacatacc cctatagcag
    12301 gaaattctaa tggcaaacca ccactcattc ttactccatt ttttgcagct tctgctattt
    12361 catcaagatg cagatgacca ggaatcacct cattttgtgc atttactata cctattaatg
    12421 gtctttcaat ttcttcttta gtaagaccca ttccatacat taacgctctc tttggagctc
    12481 cttctattcc tttttttata tcacttctca taatattacc tctttcttac ttttttaaat
    12541 tttcataata ttattataat atatttttct attaattaat tacgaaaatt gtaaaaaaat
    12601 attagcatat actaatgaaa atttattacg attttttatc aatatcttac acaattgtat
    12661 tatataatat tatcttttca atatatttta taaactaata tattttacaa attgttgagt
    12721 aatattttat gatataaatc agaagaggca cttctataat agaaagtgct caactatgaa
    12781 taagattaat aatatatttg ccttagatat atagactttt ataaatatta aagattaatc
    12841 aaatctgatg tttgaaactt tatcccaatt aatcttcctt gaatagtctt ctggatgtga
    12901 taatctaact atatgagttg aattatcata gctgtaataa attgtagtag taccatcaac
    12961 tggattcttt ttgtatcctt gatacacagc actatttggt actttctttt caacaaagct
    13021 atatgcagat gaagtatcaa tagtttctat tttattagga aatataaaca tataaaaagc
    13081 tactactata aaaatacata tgcatgtaat actataccat ttaatccatt tcataaaatt
    13141 cctcctactt taccaaaata tactattatt atttcc
//
LOCUS       DAEPID010000097        12899 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.097, whole genome shotgun sequence.
ACCESSION   DAEPID010000097 DAEPID010000000
VERSION     DAEPID010000097.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 12899)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 12899)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..12899
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.097"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            29..1090
                     /locus_tag="KR257_003277"
     CDS             29..1090
                     /locus_tag="KR257_003277"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429523.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GHKL domain-containing protein"
                     /protein_id="HBH0031946.1"
                     /translation="MIFYPIIIGLNFLFINNPIYEELIHSKEYILILSIVQIISALIK
                     LLFWFLIHIFLKNRLVNIKQYLSNKIWIFIDMVCISSFLSILIAIILPPTNLIPMGSN
                     KNIILGNLPYGTYLIILSAILANIGVILLLQPLIENVKMKIEKQANHLKEKYYNLLEN
                     QQIQIRKMRHDMNNHFQMIESYLEIEDIAGAKKYFNQLKIGIGTLSGKQFCKNQALNS
                     ILNLRHTSLEENGVDVHFNIDIDNHLGIEPIDLCTIFSNSLDNAIEASLKIPDLSNRK
                     VVLKARCEKEYFSYLLTNNKVNPINRKQELFISDKKDSNSHGYGIENIREIVNKYNGK
                     LDISYTENEFSLFLYIRLF"
     gene            complement(1426..1995)
                     /locus_tag="KR257_003278"
     CDS             complement(1426..1995)
                     /locus_tag="KR257_003278"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860876.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GrpB family protein"
                     /protein_id="HBH0031947.1"
                     /translation="MKKKLEDMTLEELWNLFPIFLTTHKECWKNWFKEEQYRLTGILP
                     MQKIVRISHIGSTSVSTIYAKPIVDILIEIIPDYNMKDIKDLIESNGYICMSESSSRL
                     SLNKGYTVDGFEERVFHLHIRYVGDNDELFFRDYLIDHPDVAKEYEKLKLDLWKKYEH
                     NRDAYTDSKLDFVREFTEKAKVLYFNRYN"
     gene            complement(2351..3364)
                     /locus_tag="KR257_003279"
     CDS             complement(2351..3364)
                     /locus_tag="KR257_003279"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902025.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="M56 family metallopeptidase"
                     /protein_id="HBH0031948.1"
                     /translation="MVSSFLNDIFRTILVSCIFIVILLVFRITLFKIFSKKFNYYIWL
                     IVIIKLSLPFMNYTFIFNESKYNGNINKISLGNFNSISIVYSTVLVSVWIAITIFYLV
                     YTLLKYIKLKNMINDLSYDVEDDKIKNLYENLLKELKINKKIRLKYSYEVESPVFFNS
                     CVILPPSDYTLKELNWIFRHELMHFKSKDLYIKYLVIFLKCVYWFNPFVYIMEKFIDL
                     DCEFYCDERVLKNCTIEEKQDYALTIISAMRKGSNSSNKFVAGLHKESDIKKRVFSMF
                     NEKYRNGILIAVILCLLSSITYFKIDLITTKSIFYPLSKQTPIENRTNSKPTYQINVY
                     IDN"
     gene            complement(3976..4878)
                     /locus_tag="KR257_003280"
     CDS             complement(3976..4878)
                     /locus_tag="KR257_003280"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895617.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="chloride channel protein"
                     /protein_id="HBH0031949.1"
                     /translation="MLPQDYYGLIVILGVILGVMGAFYNWFTLYVQSLYKKIPKIGTF
                     GKLLIPFIMAGILGLVMPDVLGSGHNLVEELTSHEYIFGMVVLIFVIRFIFSAVSFGS
                     GAPGGIFFPLLVLGAFIGGIFGMVGVKVFGMNPDYVNNFVLLAMAGYFTAIVRAPLTG
                     IILIFEMTGSVSQMLSLSVISIVAYIVATLMKSKPIYESLLERLLEKNGEPVHKERGE
                     KILDQFSVMFGSPVANKAIQDVQWPENCLLVAIQRGGEEIIPRGKTILRPSDVIVTMT
                     DERDSGAVYDKMENLCKEHTSHIF"
     gene            complement(5005..5124)
                     /locus_tag="KR257_003281"
                     /pseudo
     CDS             complement(5005..5124)
                     /locus_tag="KR257_003281"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888399.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
     gene            complement(5670..6332)
                     /locus_tag="KR257_003282"
                     /pseudo
     CDS             complement(5670..6332)
                     /locus_tag="KR257_003282"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016440163.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="chloride channel protein"
     gene            complement(6492..7028)
                     /locus_tag="KR257_003283"
     CDS             complement(6492..7028)
                     /locus_tag="KR257_003283"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438861.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GrpB family protein"
                     /protein_id="HBH0031950.1"
                     /translation="MIGLKCGMVKLLEHQMIWDKSAKDVIILLKSIWDKTAIDIQHIG
                     STSIPSISAKPIIDIVVGVASLEEAKLYLERLEQCGIVFRGQDVPKQLLFAMGDFEKN
                     TRTHHIHVVEWNGVAWNNYINFRDYLNTFTDKAKLYDSHKQKLALQFEDNRKIYTQRK
                     QELINILLEEARLWRINT"
     gene            complement(7101..7514)
                     /locus_tag="KR257_003284"
     CDS             complement(7101..7514)
                     /locus_tag="KR257_003284"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003507530.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3795 domain-containing protein"
                     /protein_id="HBH0031951.1"
                     /translation="MKMPKESIDTIMFAPCGMNCMVCYKHCYHKKPCAGCLNGDTGKP
                     EHCRKCKIKDCVCQKGLFYCFECFNFPCKLIKNLEKSYNKRYQASLMENSKFVQQYGL
                     EKFMQKQKERYTCSKCGGIISIHDRECSECQEKVK"
     gene            7980..8597
                     /locus_tag="KR257_003285"
     CDS             7980..8597
                     /locus_tag="KR257_003285"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895615.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="plasmid stabilization protein"
                     /protein_id="HBH0031952.1"
                     /translation="MDEKILELLQEMQGSISGIEGTISDMQSNINGIEGTISDMQSNI
                     NGIEGTISSMQGNINGIENTISGMQGTIGDMQGSISGMNGTISDMQGSISSMDGTINS
                     MQDSITDMQVEIKEVNSKLDNMEPDIKDLKTGQVETSSRLDTIQSDVTEIKSDVKINR
                     NTLDTVIKHTSSLVKDTSDIKNDLNNIEIVTSKNSNDIAKLKSVK"
     gene            complement(9205..9384)
                     /locus_tag="KR257_003286"
     CDS             complement(9205..9384)
                     /locus_tag="KR257_003286"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888392.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="methyltransferase domain-containing protein"
                     /protein_id="HBH0031953.1"
                     /translation="MLQTGKQGADKKYLDNMFFVKGYVEELLFLDNNYNIVFSCIVFH
                     HCTNVQNIFCIFWKW"
     gene            complement(9610..10143)
                     /locus_tag="KR257_003287"
     CDS             complement(9610..10143)
                     /locus_tag="KR257_003287"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895614.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="methylated-DNA--[protein]-cysteine
                     S-methyltransferase"
                     /protein_id="HBH0031954.1"
                     /translation="MQYISYYHSPIGNILLASDNIGLTGLWFENQKYYAYNLDQEHQE
                     KELPIFEQTKKWLDIYFSGKEPDFTPSLHMVGTPFQTTVWKILQQIPYGKTITYGEIA
                     YKVAQQKGISKMSAQAIGGAVGHNGISIIIPCHRVVGTNGSLTGYAGGINRKIKLLSL
                     EKVSVQHYFIPKKGSAL"
     gene            complement(11564..12136)
                     /locus_tag="KR257_003288"
     CDS             complement(11564..12136)
                     /locus_tag="KR257_003288"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438889.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="manganese catalase family protein"
                     /protein_id="HBH0031955.1"
                     /translation="MWIYQKTLEHPVNIRQADPRMAKYIMTQLGGPNGELAAATRYLQ
                     QRYTMPTGKSRALLTDIGTEEMAHVEIISSVLYQLIGNCTPEELKAAGLGSNYANFGH
                     GLQPVDSNGVNFTTSYINVFGDSVTDLHEDMAAEQKALATYYQLINLTDDPDLKDILR
                     FLGEREVVHYQRFGEALMDVYEFTECKHQF"
     gene            complement(12198..12461)
                     /locus_tag="KR257_003289"
     CDS             complement(12198..12461)
                     /locus_tag="KR257_003289"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438891.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="spore coat protein CotJB"
                     /protein_id="HBH0031956.1"
                     /translation="MSLNRRELLERISEYQFACIELNLYLDNNPRDKKALDSYNRYCD
                     KFTQAVCDYESKYGALTNFGYESSEYPWSWISEPWPWDKSFYK"
     gene            complement(12461..12682)
                     /locus_tag="KR257_003290"
     CDS             complement(12461..12682)
                     /locus_tag="KR257_003290"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429541.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="spore coat associated protein CotJA"
                     /protein_id="HBH0031957.1"
                     /translation="MGYLKEDKQDYCCEFARPYINRQIYDDTYNPKTALKRGTLFPEL
                     DLIESNNYNDWLYANPKNRVRAKKGGNMY"
BASE COUNT         4579 a         2192 c         1460 g         4668 t
ORIGIN      
        1 caaattaatt cctataatat cagttgtcat gatattttat cctattataa ttgggcttaa
       61 ttttcttttt ataaacaacc ctatatatga ggaacttata cactcaaaag agtatatttt
      121 aatactttca atagtccaga taatttctgc tctaattaaa ttattatttt ggtttttaat
      181 acatattttc ctaaagaata gattggtcaa tataaaacaa tacttatcaa ataaaatatg
      241 gatttttatt gatatggtat gtatatcttc atttttatca atattaattg ctattattct
      301 gccacctact aatttaatcc ctatgggtag taataagaat attatcttag gcaacttacc
      361 ttatggcact tatctaatca tcttgtcagc aattctggca aatatcggtg tgatacttct
      421 tttacagcca ttgattgaaa atgtaaagat gaagatagaa aaacaagcaa atcatctaaa
      481 agaaaaatac tataacttac tagaaaatca acaaattcaa atacgcaaaa tgcgacatga
      541 tatgaataat cactttcaaa tgattgaatc gtatttagaa attgaagata ttgctggagc
      601 taaaaagtat tttaatcagt taaaaatagg tataggtact cttagtggca aacagttttg
      661 caaaaaccaa gctcttaact caattttaaa tcttcgtcat acaagtttgg aagaaaatgg
      721 tgttgatgtg cactttaata tagatataga caatcacttg ggtatagaac ctatagattt
      781 atgtactatt ttttcaaatt ctttagataa cgctatagaa gcatctttga agattcctga
      841 tttgtcaaat agaaaagtgg tattaaaggc acgttgtgag aaggagtatt ttagctattt
      901 attgacaaac aacaaggtaa atcctatcaa tagaaaacaa gaactattta tttcagataa
      961 aaaagatagt aattctcacg gatatggtat tgagaatatt agagaaattg ttaataagta
     1021 caatggaaaa ttggatatct cttatactga gaatgaattt tctttatttc tttatattag
     1081 attattttag tctaaaatta gattatctta tataatacaa attagattgt ttgatactat
     1141 gtaaaattat aataacttat aattaaatat ttacacatat attcattaac ttaaaattta
     1201 atcaaatgtg atattttatt taccttagta aaaatgtgtg tgtctcaaaa taaacttttt
     1261 agttgatgag gcactctttt ttacatgaaa tcaaatatat ttttatcctt tcaacaatga
     1321 aaaagggatt tatctctcca ttttgaaaca accccttttt ctattaatta ctttcttaaa
     1381 aaatataata cgatatataa gataaatatc taattgtacc tatttctaat tatatctatt
     1441 aaaatacaac acctttgcct tttcagtaaa ctccctaaca aaatctagtt tactatctgt
     1501 ataagcatca cgattatgct catacttctt ccaaaggtcc aacttaagtt tttcatactc
     1561 ctttgcaaca tctgggtggt caattaagta atctctaaaa aacaactcat cattatcacc
     1621 tacatacctt atatgcaaat gaaaaactcg ttcttcaaac ccatctactg tatacccttt
     1681 attaagtgaa agcctactac tgctctcaga catacaaata tatccattcg actcaatcaa
     1741 atctttaata tctttcatat tataatcagg aattatctca atcagtatgt caacaatggg
     1801 cttggcataa atcgtactca cagaagtact tccaatatga cttattctaa caattttttg
     1861 cattggcaat attccagtta gtctatattg ttcttcttta aaccaatttt tccaacattc
     1921 tttgtgagta gtcaaaaata taggaaacaa gttccataac tcctctaaag tcatatcttc
     1981 caacttcttt ttcattagtt acctcctttt aaatttgtac tttatatttt ttctttttca
     2041 aatttactta gttaatattt aactttattt tttatcaaat catttttcta attatgtaaa
     2101 tttttctaaa tttagttttt aatgtattat aacagatttt tacccttctt acacttgtgt
     2161 atttctttaa atattagaac actttttaat ctgcaattgt agtaaaatat ttttctttac
     2221 ctgtatttac tggcattgga gcttctaaag aataattcat tggctttaat ataattaaag
     2281 taaatttaac atatgtgaaa gatacttatt aaaattattt atattaatct cttgttaaac
     2341 tttgtatttt ttaattatct atataaacat taatctgata tgtaggtttt gaattagttc
     2401 tgttttcaat aggtgtttgt tttgaaagtg gataaaatat tgatttagta gtaattaaat
     2461 caattttaaa atatgtaata gaagataata aacataaaat aactgctatc aaaataccat
     2521 ttctgtactt ttcattaaac atactaaaca ctcttttttt aatatctgac tccttatgta
     2581 atccagccac aaatttattt gaactatttg aaccttttct cattgcacta attattgtca
     2641 atgcataatc ctgcttctct tctatcgtac aattcttcaa aactctttca tcacaataaa
     2701 attcacaatc caaatctata aacttctcca ttatatacac aaaaggatta aaccaataaa
     2761 cacattttaa aaatatcacc aaatacttaa tataaaggtc tttactctta aaatgcatca
     2821 actcatgcct aaatatccag tttaactctt ttaatgtata atcacttggt ggtaaaatga
     2881 cacacgaatt aaaaaatact ggactttcaa cttcatatga atatttaagc cgtatttttt
     2941 tatttatctt aagctctttt aataaatttt cataaagatt ttttatctta tcatcctcaa
     3001 catcataaga caaatcattt atcatatttt taagcttaat atatttcaat aaagtataaa
     3061 ctaaataaaa tatcgtaata gcaatccaaa cagagactaa aacagtacta tatacaatag
     3121 aaatactatt aaaattgcct aaacttatct tattaatatt accattatat tttgactcat
     3181 taaatataaa agtataattc ataaatggta atgatagctt aataatcaca ataagccata
     3241 tatagtaatt aaatttttta ctgaaaatct taaataaagt tattctaaag actaataaaa
     3301 taactataaa aatacaactt actaaaattg ttctaaagat atcatttaaa aatgaactaa
     3361 ccacagatac tcacctttct tatactttta tatttatata atcatctaca cgaatactaa
     3421 actgatatgt aggtttttaa ttaactttgt tttcaatagg cgattgtctt gaaagtgttt
     3481 taaaagttga tataacaatg atttaggagt aataaggtca attttaaaat atgtaataaa
     3541 atataataag catgaaacaa ctgctatcaa gataccattt ccaaactcta taagcaaaag
     3601 gggctaatac aaccttaacc ccttttaatt attttcattt ataaataaat tctattcttc
     3661 ccaaaatatc gcaattaaaa tatattaatt aaaatatccc agtaagaata tctgaaaaat
     3721 cttctaccta ttttttcaaa ccctttattc ccattcctca tacaatagtg caacttttag
     3781 cacagtataa atataccatt agtccatata atctcattaa caaatatata caattatttt
     3841 cttcaaactc ttttacatct aagatatcac attttcattt tcttatatta attccttaac
     3901 tctctttcaa attaccaatt ttttaatcaa atcttcatta aatattctat cattattaaa
     3961 cattcatcat tatccctaaa aaatatgtga cgtatgttct ttacacaaat tttccatctt
     4021 atcatacaca gcaccactat ctctctcatc tgtcatagtc acaattacat cacttggtct
     4081 aagaattgtc ttacctctag gaataatttc ttctccacct ctttgaattg ctaccaaaag
     4141 acaattttca ggccactgta catcctgaat tgccttgttc gcaacaggag agccaaacat
     4201 aacagagaac tggtctaata tcttttcgcc cctctcttta tgtacaggtt ctccattttt
     4261 ttcaagtaac ctctcaagaa gactttcata aataggttta gacttcataa gtgtagccac
     4321 aatatatgcc acaattgaaa ttactgatag tgaaagcatt tgactaacag aacctgtcat
     4381 ttcaaaaatt aatatgatac cagtcaaagg ggcacgcaca atagctgtaa aatatcctgc
     4441 catagccaaa agcacaaagt tatttacata atcgggattc attccaaaaa ctttaacacc
     4501 taccatacca aatattccac ctataaatgc tcctaaaaca agcaatggaa aaaatattcc
     4561 ccctggtgca cctgacccaa aactaacagc cgaaaatata aaacgtataa caaaaatcaa
     4621 aacaaccatt ccaaaaatat attcatgact tgtaagttct tcaactaaat tgtgtccact
     4681 ccccagaaca tcaggcataa caagcccaag aataccagcc attataaatg gaatcaacag
     4741 ttttccaaac gtaccaattt taggaatctt cttgtataaa gactgcacat atagagtaaa
     4801 ccagttgtaa aatgccccca taactccaag aataacacct aaaatcacta ttaatccata
     4861 ataatcttgt ggcaacacat ttccaatctg aacctcccat gactaaagtc acagggttcc
     4921 tgcttcatag aattttgcat actaacatat gtcttactaa ttctccacag gctatccccg
     4981 tagttcctac ggttcttaca taagttattt attttgaatt gttattagtc ttaatccttc
     5041 ttttaatata tttatacttg catttatatc tctatcgtga gtttcattac aactaggaca
     5101 aatccattct cttataataa tgttaacaaa tgtaattatt taaaacaatt atttagaagg
     5161 ttttatattt aattttaaat aacatattta agaaccgtaa gtcttaactt ttatcatttt
     5221 tgaggttgtc gttcacataa gttcgctact acctatgcag ttctcttatg aacttcttac
     5281 actttcatgc aagcacagac tatatcttat ccttcggcat tatccgttaa ggtctaccca
     5341 cttccactac caatagcttg tagtgtactt ccctcaagag gaatagtcgt tgaagtttct
     5401 cctattcgga gtttacctgc tgattgccca ttttaaagta cttaggattt aaccttatac
     5461 catctaacca attttttcta ctttcgtaac tttcacactt aggtttattt catccttatg
     5521 ttttagtttg gttagcttta ggggtttcca gcaattcaag tagtattgga taggttctat
     5581 cctatctcta catataggtt tccctatatg ctgactattt tagctactaa ctcatgacta
     5641 aagtcacaag tgtgcgtagc tattttttaa tcaaactgga atacagactc cattcctagg
     5701 aaattggctg aaatatagtc tgctgtcaaa gatgctgtca tcacagaaat taaaacagat
     5761 actgaaaagt ttttatggac ttcttcaagt gaaaacataa cacccgccag tggtgcatga
     5821 aaggctgctg ataatccagc acttgcccca caggttaaca ggaatttttc ctctgtcttc
     5881 cctcggtcaa gagctctaga aataccttta cctgccatag caccaagctg aatggaagga
     5941 ccttcccttc ccaaagcaag accacccatg agtgataaga atcctccaat aaattttgtt
     6001 ggcaacactc gccaccatac ttgttttatt ttccctgtca tttccccctc aagctgaggg
     6061 ataccacttc cagaaatcat tggctcccag tccaccaact ttgatacaat ccatgcaagt
     6121 actgcaagta ctgcaaacca agctattatt tttattgtag aaccttctac aaattttaaa
     6181 atttggctaa gccaagtacc agcctgccct aaaagtatcc tgtataaaag cacaatcaaa
     6241 ccagccacag ccccaaccat aagtccttca ccaatcaaaa ttacctgaaa gtgctctgcc
     6301 cgtttgataa tatgagatgt atcctttttc atactgttcc tccttcatcc aataattcta
     6361 cacaatctga atctccaatg actaaagtca tgagtgtgta cagatatttt ttaatcaaca
     6421 aaaatagatt tttatttact aaatataaga aaataattgc tcaatttctc aataaatgta
     6481 aatttattct tttaggtatt tattctccac agtcgtgctt cttccagcaa aatatttatt
     6541 agttcttgct ttctctgtgt atagatttta cgattgtcct caaactgtaa tgccaatttt
     6601 tgtttatgac tatcatagag ttttgctttg tctgtaaaag tatttagata atctcgaaaa
     6661 ttgatataat tattccatgc aacaccattc cattcaacaa catgaatatg gtgagtacga
     6721 gtatttttct caaaatctcc catagcaaaa agtaattgtt ttggtacatc ctgacctcga
     6781 aaaacgattc cacattgctc taacctttcg aggtataatt tagcttcctc taaagaagca
     6841 acacctacaa caatatcaat aataggcttt gcgctaatac tgggaataga agtgcttcca
     6901 atgtgttgaa tatcaatggc agtcttatcc catatacttt tcaataatat aatgacatct
     6961 tttgcacttt tatcccatat catctgatgt tccaataatt taaccatacc acattttaaa
     7021 cctatcacta tataccacct caatataatc cacctttata tatattacaa ttttttctct
     7081 cttgataaac agtgatttag ctatttcact ttttcttgac actcgctaca ttccctatca
     7141 tgaatagata taattcctcc acatttagaa caagtatatc tctccttctg cttttgcata
     7201 aacttctcta aaccgtactg ctgaacaaat ttactatttt ccataaggct tgcttgatat
     7261 ctcttgttat aacttttttc aagatttttt atgagtttac aaggaaaatt gaaacattca
     7321 aaacaataaa acaacccttt ttgacagaca caatccttta ttttacactt acggcagtgt
     7381 tctggctttc ctgtatcgcc attcaaacaa ccagcacatg gctttttgtg ataacaatgc
     7441 ttatagcaaa ccatacaatt cattccacaa ggagcaaaca taatcgtatc aatactctct
     7501 tttggcattt tcataacatt ttactccttt caaaaatcca atttgtcgaa ttgttatata
     7561 ttcatattgt aacataaaaa atagctaaaa aattcatgca ctttcattgc caataaattt
     7621 tcaaggaaat atgaaagttt aaaactaaga ataaaaagag ataaaaagga agctactaat
     7681 caaattattc aaatacaagt aatcaatata aataacttaa ggtatattta aaagtatatg
     7741 atattaccag cagttttaaa tacaaatata accacacatg cctcaaaaac acttattaca
     7801 gtatcttaga aacttagaca atacataaga ttcattaata aaaaagttct caatatagat
     7861 atatttaacc atgttttgaa tagcagataa tcatatgatt aaaaattaaa tatgacatag
     7921 cgtttgtgga atataacacc taaattatgt tataataata aaacaggagt gtgatagtga
     7981 tggatgaaaa aatattagag ttattacagg aaatgcaagg tagtatcagt ggtatcgaag
     8041 gcactattag cgatatgcaa agcaatatca atggtatcga aggcactatt agcgatatgc
     8101 aaagcaatat caatggtatc gaaggcacta ttagtagtat gcaaggcaat atcaatggta
     8161 tcgaaaacac tattagtggt atgcaaggca ctattggcga tatgcaaggt agtatcagtg
     8221 gtatgaatgg cactattagc gatatgcaag gcagtatcag tagtatggat ggcactatta
     8281 atagtatgca agacagtatt actgatatgc aagttgaaat taaagaagtc aatagtaagt
     8341 tagacaatat ggaacctgat attaaagact taaaaactgg acaagttgaa actagtagta
     8401 gacttgatac tattcagagt gatgttacag aaattaagtc agatgtaaaa attaacagaa
     8461 atacattaga tacagtgatt aaacatacct cttcattagt aaaagataca tcagatatta
     8521 aaaatgattt aaataatata gagatagtca catctaagaa ttcgaatgat attgctaaat
     8581 taaaatcagt taaataatat accatagtaa aaaatacctg aaaatttcac atacttcttt
     8641 aaagttatac caaattttat acagaaatac tgattatccg acaacacact ttacttataa
     8701 ataatttatt aaaaaaatac tcattttatc ctaaaattaa cacgactaaa tgagtcttga
     8761 tataataata aaaaataagg gagattggac actaaaaagt tgtgtatctc ccttatatcc
     8821 tataatatag ttatataatt tttcagccta aaataaaagt ccatctttga ttaaaacaca
     8881 tccccttatc acttataaaa ggataaaatc ttgttttcat ttttccattt atatcttctt
     8941 gcttaagagt aataattttt tcttttgata ctttaagtgt ttggttaaat ttaactaatc
     9001 gactaagttt tgttcaacat ctatttttca tattttccaa tacttaatct attttttata
     9061 aataattctt tcatttctaa ctcacttaca ttttttacat aaaacgaaac atataaattt
     9121 caaccttatc ttgtatggtt cttaatactt aatgagtagc ttaagtatca atcattataa
     9181 atttttccct tacatttaac actcttacca tttccaaaat atacaaaata tattttgaac
     9241 atttgtacaa tgatgaaata caatacatga aaatacaata ttataattgt tgtctaaaaa
     9301 tagaagttct tcaacataac ctttcacaaa aaacatatta tctaagtatt ttttgtctgc
     9361 tccttgtttt cctgtttgta gcatataaat tacttcctct aaacatataa ctactcacat
     9421 gaaaaaagaa aataaacttc caaaatacaa gctctaaaaa ctacctctaa agttgtataa
     9481 tgtttactag gaataaggtt gtataacata tagtttaaat aatcattttt taaaattgca
     9541 agttattgct ttcaaaatta gatgtttgta tatcaaataa atgattaaga atttctaaat
     9601 ttaatggctt tataatgcac tccctttctt tgggataaaa taatgttgca cagatacttt
     9661 ttctaaagat aacaatttta tttttctatt aattccacca gcatacccag tcaaactccc
     9721 atttgttcct acaacacgat gacatggaat aataatagag attccattat gccctactgc
     9781 accaccaatt gcttgtgctg acattttaga tattcctttt tgttgagcaa ctttatatgc
     9841 aatttctcca taagtgattg ttttaccata tggtatttgt tgtaaaattt tccacactgt
     9901 agtctgaaaa ggagtaccta ccatatggag tgatggtgta aaatcgggtt cttttcctga
     9961 aaaataaata tctaaccatt tctttgtctg ctcgaaaatt ggcaattctt tttcttgatg
    10021 ttcttggtca agattataag cataatactt ttgattctca aaccaaagac cagttaaccc
    10081 aatattatct gatgctaaaa gaatatttcc aattggacta tggtaatagc taatatattg
    10141 catacaattc ctccttatat tctgaaaact tcactcaaat cattagacac ttcttttcta
    10201 tctaccatta tgtaaaaaca tactaatata atttccttct aactacactt tcgttataat
    10261 atctatcctc atatcatatt agttttatat ttacctgcat ctgttcatcc ttttttccct
    10321 ttccctttga tggatataaa attcatacat ttaagcttcc tactgtatta acttttatag
    10381 aagtgtatct tataatttta tcactaaata gaccaaaaaa atatcgatat agcatcaagt
    10441 aatatcataa tactttcaaa tgggaaaagt aagaataggc tgtaaaaaag aaaagtattt
    10501 ttatgttaga aatccagtaa aatcgttagt agatagaata acagaaaacg aacaatttgc
    10561 tatttatcat tttacacata aatataattg acgcaataaa gtgttttcta ttctacaacg
    10621 attaataagg ttagaaaaaa gtaaaaatga actgtatatg tatgaagcat tagtttctgt
    10681 ttctttcctt tggcttatta tgataaaaaa tattgttttg ccaccaataa aacacaaaaa
    10741 tataattaat atccatatgc aaaaaatttt acgttatatt gaaaaatact attgttttac
    10801 attatattga agggtactat tgtgaaaact taattttgga gtactatcaa gcagtggtaa
    10861 tatcaataaa tcagagtgct ccagatgatt tgaactaagt ttaaatacta taccttataa
    10921 atattttact gagttttgtt tattaaaagc aactcaattt ctaaaaggca caaatgagct
    10981 aataagtgac attactataa aagttgtttt tcatcaaata atctatttta gtaaatgttt
    11041 taaagaaaaa acgggatatt ctccaaaagt gtacagaaat ataaaaaaag agatatgatt
    11101 ttttatttct tttgattatc caaagagtaa ataaaaaata ttgtaaaaaa cttactaaca
    11161 acggcaatgc tttgaactat ggtaatactt tgaacttttg attggacttt ttttgctaaa
    11221 ataatatatt taaatagcaa agtaatctgt ttaatcaata aaaaataaga gataaaagaa
    11281 atcaactaaa acttttacct cttattttga tagtttatca gagctaatat ttacactctt
    11341 tttatttttg atacttcatt aaaaatgatg cttattctct tttcattttt aatacttcat
    11401 tagaacttat gcttattctc ttttcacttt taattcttca ttagaactta tgcttactct
    11461 ccattcactt ttaattcttc attaaaaatg atgcttactc tccattcact tttaattctt
    11521 cattaaaaat gatgcttatt ctccattcac tttcaattct tcattaaaac tgatgcttgc
    11581 actctgtaaa ctcataaaca tccattaatg cttcaccaaa tctttgatag tgaactactt
    11641 ccctctcacc caaaaatctc aatatatctt tcaaatcagg gtcatcagtt aaatttatta
    11701 attgatagta cgtagccaat gctttttgtt cagcagccat atcctcatgt aaatcagtta
    11761 ccgaatcgcc aaagacatta atataacttg tagtaaagtt tactccatta gaatctactg
    11821 gctgaagacc atgtccaaaa ttagcataat tactaccaag tccagcagcc ttaagctctt
    11881 ctggagtaca attgcctatt aattgatata acactgaaga aattatctca acatgagcca
    11941 tttcctctgt acctatatca gttaaaagtg cacgagattt tccagttggc atagtatatc
    12001 tttgttgaag atatctagtt gcagctgcca actcaccatt aggtcctccc aactgagtca
    12061 tgatatattt tgccattcta gggtctgctt gtcttatgtt aactggatgt tccagtgttt
    12121 tttgataaat ccacatatta tcttactcct ccttaatata tatttaataa taaatctaat
    12181 tttaaagttt aataatttta tttataaaat gatttgtccc atggccaagg ttcagatatc
    12241 catgaccaag gatattcact tgattcatat ccaaaattag ttaatgctcc atatttagat
    12301 tcataatcac acacagcttg tgtaaattta tcgcagtatc tgttgtatga atcaagagct
    12361 ttcttatccc ttggattgtt atctaaatat aaatttaatt ctatacaggc aaattgatat
    12421 tctgaaattc tctctaaaag ttctcttcta tttaatgaca ttagtacatg ttaccccctt
    12481 ttttagctct aactctattt ttaggatttg catatagcca atcattatag ttatttgact
    12541 ctattaaatc taattcagga aataaagtac ctctttttaa tgctgttttt ggattgtatg
    12601 tgtcatcata aatttgacga ttgatgtatg gtctagcaaa ttcacaacaa tagtcttgtt
    12661 tatcctcttt taaatatccc attaattatc ctccttaatt tttagaattt taaaatagca
    12721 ttatttttaa aaattgtata ctggttctat attataactg gtagttttaa taggtcttta
    12781 ataagattaa atgattaaat aagtatcttt ttttcttatt ttacctctaa aatttttcta
    12841 attaatcttt cataaatatc tattttaaat aaataatata gagtttatac aatttttta
//
LOCUS       DAEPID010000098        12850 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.098, whole genome shotgun sequence.
ACCESSION   DAEPID010000098 DAEPID010000000
VERSION     DAEPID010000098.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 12850)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 12850)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..12850
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.098"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            212..613
                     /locus_tag="KR257_003291"
     CDS             212..613
                     /locus_tag="KR257_003291"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422946.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0031958.1"
                     /translation="MKKCLYCNRDIKSPNNKLAIKYDDNMNIYPCRAECKEKIEEYIA
                     KKPTYKFINILEVLLGVGGIFCFLSKWTIAAQVVLGIDALVIFLFPLAGFKMNGKLSM
                     EQTKNQSRSIAISILAFIVIITVLYFKQIGK"
     gene            656..949
                     /locus_tag="KR257_003292"
     CDS             656..949
                     /locus_tag="KR257_003292"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422948.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="metal-sensitive transcriptional regulator"
                     /protein_id="HBH0031959.1"
                     /translation="MEERKLAPNNEREALIKRLKRIEGQVKGIQKMVEQERYCVDILV
                     QISAIRSAINRVGTIILENHIKGCVAESIKHDDADKTEEMIKELMDTINKFTK"
     gene            964..1404
                     /locus_tag="KR257_003293"
     CDS             964..1404
                     /locus_tag="KR257_003293"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454154.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SoxR reducing system RseC family protein"
                     /protein_id="HBH0031960.1"
                     /translation="MNQQGFIMEIVDDRTAKLKMQRHSACAACGKCATTNSAESKEIL
                     VEVDNTIGAKVGDHVEVSMDNMNVLKAAVMAYIIPLIALLVGTIGTYYILGAIGMTTG
                     VEAISGLVGICLTIICYLYLKKNDKKFRDSREFIPVITRILIDL"
     gene            complement(1496..1969)
                     /locus_tag="KR257_003294"
     CDS             complement(1496..1969)
                     /locus_tag="KR257_003294"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454155.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="threonine/serine exporter family protein"
                     /protein_id="HBH0031961.1"
                     /translation="MTDMSMILHFLFSGVATAGFAVFFNAPLYLLLPAGVTGGIGWIV
                     YVYLFNFTTNAVFAGFIAAALVSACSETLARKLKQPAIVFVIPGILPLIPGIGLYNTM
                     LSLIQKNYSLAMSKGTDALFLSAAIALGVLVVTSFVRTLNLLKIRKNFIPYRKSK"
     gene            complement(1969..2757)
                     /locus_tag="KR257_003295"
     CDS             complement(1969..2757)
                     /locus_tag="KR257_003295"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422952.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="threonine/serine exporter family protein"
                     /protein_id="HBH0031962.1"
                     /translation="MNQNEELEYKKNILKLALFVGELMIKNGAETSRVEDSVLRICRS
                     RGFYHVNIFTTPTVIIISDEKFDGFSFMKTIQSRGINLNKISLLNSFSREFVSDKEYD
                     IDNAIARLYEIQDVKPYPLWLFYSCTGIASACFACLLGGNYVLNFILTFIIAIFAAIT
                     YDKTMKISAISAFSCLVSSFLIALSGVLLVEIGILDDPKMLIVGAIMPLLPGVAFIKA
                     IRDLISGNLISGISRAFDAAMIIIAIASGVGFVLDTWYRIGGPF"
     gene            3085..4329
                     /locus_tag="KR257_003296"
     CDS             3085..4329
                     /locus_tag="KR257_003296"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422953.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="serine hydroxymethyltransferase"
                     /protein_id="HBH0031963.1"
                     /translation="MFENLKKADPEIYESMKRELKRQQRNIELIASENIVSVPVMETM
                     GSHLTNKYAEGYSGKRYYGGCEYIDEVETLAIDRIKKIFGAEHANVQPHSGANANIGV
                     YFAMLKPGDVVMGMNLSQGGHLTHGAPVNISGQYYKFYEYGIDKDSGLIDFDEVRKIA
                     HEVKPKMIVAGASAYPREIDFKKFREIADEVGALLMVDMAHIAGLVAAGLHQNPCEVA
                     DFVTTTTHKTLRGPRGGVILCKEKYAKDIDKAIFPGIQGGPLEHIIASKAVCFKEALS
                     DEFKEYQVQVAKNAKALAEELIKRDFKLISGGTDNHLILLDLTNKNITGKAAEKRLDD
                     AYITANKNTIPFDPNGALVTSGIRLGTPAVTTRGMKEEDMAIIAEAIDLCLTYDEESK
                     ARTLVVGLTEKYPLYEEYNIMD"
     gene            4652..5749
                     /locus_tag="KR257_003297"
     CDS             4652..5749
                     /locus_tag="KR257_003297"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422954.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-diphospho-muramoylpentapeptide
                     beta-N-acetylglucosaminyltransferase"
                     /protein_id="HBH0031964.1"
                     /translation="MKVLILTGKFGMGHYSASNSLSEDIKAKFDNSEIIIKDIFEYIM
                     PNYSDKMYKTFSILVNRGSSLYNLFYKCAENGKKDIKFTFSDYFLNKLDTLLHEVQPT
                     VVISTFPFCSQLVSRYKEKYNSNLPLITCITDISSHSEWISKNTDCYLVASKSTKEEL
                     VFKGIDESKIKVNGIPVKKEFKRIEHVNHSTKKNILIMGGGLGLLPKSEQFYKELNSL
                     EGVKTTVITGNNKKMYYKLYGRYENIEVVGYTNEVYKYMKDSDLIISKPGGITLFETI
                     YSELPILAFNPFLQQEIDNASFILNNEIGRILGKNKKYYVDEIKDLIYDDATLKEMSS
                     NMKELKKQFDNNTLENILFSLDEQGACRECM"
     gene            5740..6438
                     /locus_tag="KR257_003298"
     CDS             5740..6438
                     /locus_tag="KR257_003298"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422955.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="polysaccharide deacetylase family protein"
                     /protein_id="HBH0031965.1"
                     /translation="MYVVGLIIVVALIFLVHSIIPTYYNKLLNKEVLKNMAGENEIAL
                     TFDDGPDKRYTEKLLDVLKENDIQAMFFVVAKNAEKEPEIIKRMLRENHIVGLHSLEH
                     RNAWLYSYSYVKKDFIESTNIMKNLGVDVNYYRPPWGHTNIFSNSFVKKYNLKMTLWD
                     VMAEDWEKDSTVDIIINKLMSRTKENSIICLHDAGENSGGAVGAPERTIEALKIAIPK
                     LKASGLKFVTPERM"
     gene            6441..7505
                     /locus_tag="KR257_003299"
     CDS             6441..7505
                     /locus_tag="KR257_003299"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890975.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flippase-like domain-containing protein"
                     /protein_id="HBH0031966.1"
                     /translation="MISKTEKKNKCLGSVAFLVLLMGITGYFVFRGQSVESLIKSLKG
                     ASPMFILIGFAMMFIYVACEGINIYLGMKALNQKTTLLKCMGYAFIGFYFSSITPSAS
                     GGQPAQVYYMKKDDINISYSSLILLVIVVIHQVVILAYSGIMFIMEREFILNNVSGMN
                     ILLIYGVITNVALVIGVIAIIFSKKLVNNFIISITNLLGKLRIIKDVESSRKVIISQI
                     EEYVKGAQYIKQNPKLVVQILVITIVQITSMFLVPFFVYKAFHLSTYTVFEILAIQSL
                     LNIAVSSLPLPGAVGASENSFMTLFKIFFPGHLLVPAMLLSRGISFYAFVAISGLICI
                     VVHVKSSEKVKAVKKVAYVR"
     gene            7688..8392
                     /locus_tag="KR257_003300"
     CDS             7688..8392
                     /locus_tag="KR257_003300"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426384.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HBH0031967.1"
                     /translation="MNKEIPKKILVADDNPEIREIVEILLTGEGYEVIMATNGEEAVN
                     LVDSTIDLIILDVVMPVKTGFVACNEIREKTTAPILFLTAKTQDSDKVIGFSAGGDDY
                     LSKPFSYSELISRVKSLLRRYYIYQGKEKEREPNILKTKELCVNLDTQDVTLNGEPVF
                     LTTIEYSILILMLKNRKKVFSSENLYETIWDEQYFYTANNTIMVHIRNLRKKLEKDQK
                     NPQYIKTAWGKGYYID"
     gene            8385..9707
                     /locus_tag="KR257_003301"
     CDS             8385..9707
                     /locus_tag="KR257_003301"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454160.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HAMP domain-containing histidine kinase"
                     /protein_id="HBH0031968.1"
                     /translation="MINKIKPSKLGVILLIYVVISAAVAFILNIPFYSAVESIVKDVS
                     EGKVYFKREVNQLMDNFQTYVNNNGIRADDGDDIAKWNSDNWFVSMKIYKGNKVFYDT
                     LYYPNEVPDKSEENEFYSSPMARNYEIQFSDIKANIVVVALFRFRFQNFIEAISITFM
                     ALTFIITFLLLFSRKIKYLRKIEMGIKIVESGSLKYRIPVKGNDELSSLASSINEMSH
                     TLENQLIKEREMKNKNKDIVTSISHDVRTPLTSVICYLDLIKDHKYNSPEQLEQYIKN
                     VRSKAYQIKDLTDDLFTHFVNSGEEVSKGYEKINANEFIFQLLLDSSYTLEEKGFHIT
                     IENELYNQYHIYVDVTQFRRIFDNLCSNIIKYARKDKPIVFLIKVEDSKLLIIQKNRV
                     SNFSKNVESFGIGIKNCEKIVAYHNGSINVNSDDKEFAIEISIPAKES"
     gene            9894..11267
                     /locus_tag="KR257_003302"
     CDS             9894..11267
                     /locus_tag="KR257_003302"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890970.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0031969.1"
                     /translation="MVLTGAHYIYILFMVIILITMIMKKDTIVPCILGVFFMGLFFEK
                     NIFGAITAVFNSFIISLNELGPIILIIAIMVALSKALEANNAIQYMVRPFSRVIKNSN
                     TAFFVTGFVMLVLSWFFWPTPAVALVGAVFLPVAMRAGLPAIGVAVALNLFGHGLALS
                     TDFVIQGAPSITAGAAGVAVSYVINDGMILFWVMGIVTISMAFYTLKRDINKGMFREE
                     LKGFESEEVEAFNGKSKIATILVALGFLADIIAMYVFDLKGGDASALLGGTAVFLIII
                     INVINFGKDSLENVCENIIDGFVFGIKIFGAIIPIAAFFYMGEVAPLTGVFGKVLAPG
                     SQGLLSDIGIALSQTIPLNKFAVSGIETVVGAITGLDGSGFSGISLVGSLASVFGTAI
                     NASVGALAALGQISGIWVGGGCLVPWGLISAAAICGVSPIELAKRNFVPVITGLVVTT
                     IVAMFII"
     gene            complement(11639..12577)
                     /gene="pdaA"
                     /locus_tag="KR257_003303"
     CDS             complement(11639..12577)
                     /gene="pdaA"
                     /locus_tag="KR257_003303"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897898.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="delta-lactam-biosynthetic de-N-acetylase"
                     /protein_id="HBH0031970.1"
                     /translation="MFRKVLHYLTLLSISIFFIVGCSNSQNNQNENQNKETQLQEDKE
                     KIDSGKDTSNVIVSDGTDKPSKATTNNDNNKLDVSSLDNTTLDWFYIPNNKHKTPEVN
                     TDIEFKFSDYDALYNGPTKDGQKTLYLTFDEGYENGYTTKILDTLKQNQVKAVFFVTA
                     PYIKENKDLVKRMVSEGHIVGNHSKTHPSMPTKTSNLKNFNDELYDVEKLYKDVTGKD
                     MVKFFRPPMGKYSEKSLAMTKNLGYKTVFWSFAYRDWDTDKQPSHEEATQKIMDNLHD
                     GSILLLHAVSKTSTEILNDFISNARKLGYEFELLEY"
BASE COUNT         4828 a         1490 c         2149 g         4383 t
ORIGIN      
        1 gacttatttt agattacata ataattaaat tagattaaat aatattattt aattattatt
       61 ataaatttat tatagactac acattgaagt aaaagaagta gctaaaatta ttccttttat
      121 ttttgttttt tgtatctatt tggtataata gtattagagc gtataataat ttaggcaaaa
      181 ttttttaagg aagactagag gagaatataa aatgaaaaaa tgtctttact gtaataggga
      241 tataaagtca ccaaataata aattagctat aaaatatgat gacaatatga atatatatcc
      301 atgtcgtgca gaatgtaagg aaaaaattga agaatatata gcaaaaaaac ctacatataa
      361 gtttataaat atattagagg ttcttttagg tgtgggcgga atattctgct ttttgagtaa
      421 atggactatt gcagcccaag ttgtacttgg aattgatgca ctggttatat ttttattccc
      481 attggcagga tttaagatga atggaaagtt aagtatggaa caaactaaga atcaaagtag
      541 gtctattgca atatcaattt tggcatttat agtaataata actgtattat attttaaaca
      601 aattggtaag tagagcataa ttgtataaga catcattaga gtatgaggtg agtttatgga
      661 agaaagaaaa ttagcaccaa acaatgagag ggaagctctc ataaaaagat taaaaagaat
      721 agaaggtcaa gttaagggta tacaaaagat ggtggaacaa gaacgttatt gtgttgatat
      781 attggttcaa atatctgcta taaggtctgc tataaataga gtaggcacaa ttatcttaga
      841 gaatcatata aaaggatgtg tagcagaaag cattaaacat gatgatgctg ataaaactga
      901 agagatgata aaagagctta tggatactat aaataaattt acaaaataag gaggcggtta
      961 gttatgaatc aacaaggatt tattatggaa attgttgatg atagaactgc aaagttaaaa
     1021 atgcaaagac attcagcttg tgctgcttgt ggaaaatgtg ctactacaaa ttcagcagag
     1081 tcaaaagaaa tattagtaga agtagacaac acaattggcg caaaagttgg tgaccatgta
     1141 gaagtgagta tggataatat gaatgtatta aaagcagctg taatggctta tataatacct
     1201 cttatagcac ttcttgtagg aacaataggg acttattata tattgggggc aattggaatg
     1261 acaactggag ttgaagccat aagtggatta gttggaattt gtcttacaat aatctgttat
     1321 ttatacttaa agaagaatga caaaaaattt agagacagta gagaatttat accagtaata
     1381 acaagaatat taattgacct ttaagataat tataattaaa aaatagcaat gtgcttctta
     1441 aataaatact caatacgtat ttgtagagtt taagtacatt gctattttta tatttttatt
     1501 ttgattttct gtaaggaata aagttttttc tgattttcaa aagattcaat gttcttacaa
     1561 aagaagttac aactaataca ccaagtgcta ttgcagcact tagaaatagc gcatctgtac
     1621 cttttgacat agccaaagaa taatttttct gaatcaaaga caacattgta ttatatagcc
     1681 caattcctgg tattagagga agaatacctg gaattacgaa cacaatagct ggttgcttta
     1741 gttttcttgc taaagtctca ctgcacgctg agaccaaagc agcagcgata aaacctgcaa
     1801 aaactgcatt tgtagtaaaa ttaaataaat aaacatatac aatccaacca attccgccag
     1861 ttactccagc tggaagaagt agatatagtg gagcattaaa gaaaacagca aatccagcag
     1921 ttgcaacacc tgaaaataaa aaatgcaaaa tcatagacat atcagtcatt agaaaggacc
     1981 tcctattcta taccatgtat caaggacaaa accaactcca gaagcaattg caataataat
     2041 catagcagca tcaaaagcac gagaaattcc tgatattaaa ttccctgata ttaaatctct
     2101 aatagctttt ataaaagcaa ctcctgggag tagtggcatt atagcgccga ctataagcat
     2161 tttagggtca tctaaaatgc ctatttcaac tagtagaact cctgaaagtg caattaaaaa
     2221 agaagatact aaacaggaaa atgcagatat tgcacttatc ttcatcgttt tatcataagt
     2281 aattgcagca aagattgcta ttataaacgt aagtataaaa tttaatacat aattccctcc
     2341 aagcaaacaa gcaaaacaag cagatgcaat tcctgtacaa gagtaaaata accataaagg
     2401 ataaggtttt acatcttgga tttcataaag acgtgcaatg gcattatcaa tatcatactc
     2461 tttgtcacta acaaattctc gagaaaaact gtttaataaa gaaatcttat ttaagtttat
     2521 acctcttgat tgaatcgttt tcataaacga aaagccatca aatttctcat ctgaaataat
     2581 tattactgta ggagttgtaa aaatatttac atgataaaac cctcttgacc tgcatattct
     2641 aaggacactg tcttcaaccc tagatgtttc agctccattt tttatcatca gttcccctac
     2701 aaatagagct agttttagaa tatttttctt atattcaagt tcctcatttt gattcataaa
     2761 tacacctcca aattaaaaaa cgtaatattg aaattatatc aaatttttaa gtaatattcc
     2821 ttaatatcta tacaaatata ttatcttttt tttgtttcaa aatagtcaca tttaaattat
     2881 atccaattaa aagaattaga caatattatt tattatattt taacttaaaa ataaagaaag
     2941 taactatgtt aaatatggaa aaatggcaaa acacttgact attaattggt aaaggactat
     3001 aataataaat tatcatattg ataaaaacga aaattatgaa atgtctgtaa aaataaaatt
     3061 taaataataa ctaggaggag taatatgttt gagaacttga aaaaagcgga ccctgagatt
     3121 tatgaaagta tgaaaagaga gttaaaaaga caacaaagaa atattgaatt aatagcatct
     3181 gaaaacatag tatcagttcc agtaatggaa actatgggaa gtcatcttac aaataagtat
     3241 gcagaaggtt actcaggcaa aagatattat ggtggatgtg aatacataga tgaagttgaa
     3301 actcttgcaa tagatagaat caaaaaaata tttggagcag aacatgctaa tgttcaacct
     3361 cattctggag caaatgcaaa tattggtgta tattttgcta tgttaaaacc aggtgatgtt
     3421 gttatgggaa tgaatttatc tcaaggtgga catttaactc atggtgctcc agttaatatt
     3481 tctggtcaat attataaatt ttatgaatat ggtatagata aagacagtgg acttatagat
     3541 tttgatgaag ttagaaagat agcacatgaa gtaaaaccta aaatgatagt tgcaggagca
     3601 agtgcatatc ctagagaaat agattttaaa aagtttagag agatagctga tgaggttgga
     3661 gcattgctta tggtagatat ggctcatata gcaggtcttg tggctgctgg tcttcaccaa
     3721 aatccatgtg aagtggctga ttttgttaca acaacaactc acaaaacttt aagaggacct
     3781 cgtgggggtg ttattctttg taaagaaaaa tatgctaaag acatagacaa agcaatattc
     3841 cctggtattc aaggtggacc tcttgaacat ataattgctt ctaaggcagt ttgctttaaa
     3901 gaagctttaa gtgatgagtt taaagaatat caggtacaag ttgctaaaaa tgcaaaagcc
     3961 ttagctgaag aacttattaa aagagatttt aaattgattt ctggaggtac agataatcat
     4021 ttaatactat tagatttgac taataaaaat ataactggta aagcagcaga aaagagattg
     4081 gatgatgctt atataacagc taataaaaat acaattccat ttgacccaaa tggtgctctt
     4141 gttacaagtg gaataagact tggtactcca gctgtaacta ctagaggtat gaaagaagaa
     4201 gatatggcaa taatcgctga ggctatagac ctatgtttaa cttatgatga agaatctaag
     4261 gctagaacat tggttgttgg tttaactgaa aaatatcctt tatatgaaga atataatatt
     4321 atggattaat tataaagaac aactaaataa aatacattta aataattaca atgattgtgt
     4381 atgtatttga atatatttag atataaaaaa ggtgtctcaa aatgaacttt ttagtttatg
     4441 aggcactttt ttgtatggaa tcgaacatat ttgtattatt taaataataa aaaatatggt
     4501 tatctctatt tttagatggt ctctttgtat tttttaatta aaactttaag atttcttaag
     4561 aattatacta ggtttttcta aagatttaaa gtctatactt ataagtatag taatcatatg
     4621 aaaagaaaag ctttaacgag gagggaatct tatgaaggta ttaattctta caggaaaatt
     4681 tggtatgggt cattactcag catcaaattc tttaagtgaa gatataaaag caaaatttga
     4741 taattcagaa ataataatta aagatatatt tgagtacatt atgcctaact attcagataa
     4801 aatgtacaag actttttcta ttcttgtaaa tcggggaagt agtctttata atttgtttta
     4861 taaatgtgct gaaaatggaa agaaagatat aaaatttact ttttcagatt attttttaaa
     4921 taaattagat acattacttc atgaagtaca accaacagta gttatttcaa cttttccatt
     4981 ttgttctcaa ttagtatcaa gatataagga aaaatataac tcaaatcttc ctttaataac
     5041 atgtataact gatataagta gtcactcaga atggattagt aaaaatacag actgttattt
     5101 agtagctagt aaatctacta aggaagaact tgtttttaaa ggaatagatg aatctaagat
     5161 taaagttaat ggtattccag taaaaaaaga atttaaaaga atagaacatg taaatcattc
     5221 aactaaaaaa aatattctta taatgggtgg aggattagga ttactgccta aatcagaaca
     5281 attttacaaa gaattaaata gtttagaagg agtaaaaact actgtaataa ctggtaataa
     5341 taaaaaaatg tactataaac tatatggtag atatgaaaat atagaggtag taggttacac
     5401 caatgaagta tataaatata tgaaagattc tgaccttatt atttctaagc caggtggaat
     5461 aacactattt gaaacaattt attcagaact tccaatattg gcatttaatc catttttaca
     5521 acaagagata gataatgcta gttttatatt aaataatgaa attgggagaa tacttggtaa
     5581 aaataaaaaa tactatgtag atgagataaa agatttaatt tatgatgatg ctactcttaa
     5641 agaaatgagc agtaacatga aagaattaaa aaaacaattt gataataata ccttagagaa
     5701 tattttattt tcacttgatg aacaaggagc gtgtagagaa tgtatgtagt aggtttaatt
     5761 atcgttgttg cattgatttt tttagtccat tcaattatac ctacatacta taataaacta
     5821 ttaaataaag aggtattaaa aaatatggct ggagaaaatg aaattgcact tacatttgat
     5881 gatggtccag ataagagata tacagaaaaa ttactagatg tgttaaaaga aaatgatata
     5941 caagctatgt tttttgtagt agcaaagaat gctgaaaaag agcctgaaat tataaaaaga
     6001 atgttgagag aaaatcatat agttggttta cattcattgg aacacagaaa tgcatggctt
     6061 tatagttata gttatgttaa aaaagatttt attgaaagta caaatataat gaaaaattta
     6121 ggtgtagatg taaactacta tcgtccacca tggggtcata ctaatatatt ttcaaattca
     6181 tttgttaaaa aatataatct aaaaatgact ttgtgggatg taatggcaga agattgggag
     6241 aaagatagta cagtagacat tattataaac aagttaatga gtagaacaaa agaaaattct
     6301 ataatttgtt tacatgatgc aggtgaaaat tcaggtggtg cagtaggtgc acctgagcgt
     6361 actattgaag ctttaaagat agctattcca aaacttaaag ccagtggttt aaagttcgta
     6421 acaccagaaa ggatgtagtt atgataagta aaactgaaaa gaaaaataaa tgcctaggta
     6481 gtgtagcttt tttagtttta ctaatgggca taacaggata ttttgttttt agagggcagt
     6541 cagttgaatc attgataaaa tcattaaaag gtgcaagccc tatgtttata ctaattggat
     6601 ttgcaatgat gtttatatat gttgcctgtg aaggtataaa tatatactta ggtatgaaag
     6661 ctttaaacca aaagactact cttttaaaat gtatgggata tgcttttatt ggattttatt
     6721 ttagttctat tacgccttca gcatcaggtg gtcaaccagc acaagtttat tatatgaaaa
     6781 aagacgatat aaatatatca tattcttcac ttatactatt agtcattgtt gttattcacc
     6841 aagtagttat actggcatat agtggaataa tgttcattat ggaacgtgag tttatattaa
     6901 ataatgtaag tggtatgaac attttactaa tatatggtgt aataacaaat gttgctcttg
     6961 tcattggagt aattgcaatt atattttcaa aaaaacttgt aaacaatttt ataatatcaa
     7021 taacaaattt attaggtaag ttaagaataa taaaagatgt tgaaagttca agaaaagtta
     7081 taatatctca aattgaagag tatgttaaag gtgctcaata tataaagcag aatccaaaac
     7141 ttgtagtcca aattttagtc ataactattg tacaaataac atctatgttt ttagttcctt
     7201 tctttgtata caaagctttt catctatcaa catatactgt atttgagata ttagcgatac
     7261 aatccttgct taatattgct gtttcttcat taccattgcc aggggctgtt ggagcttctg
     7321 aaaatagttt tatgacatta tttaagatat ttttccctgg tcacttatta gttccggcaa
     7381 tgttacttag taggggaata agtttttatg catttgtagc tataagtgga ttgatatgta
     7441 tagtagtaca tgtaaaatct tctgaaaaag taaaagcagt gaaaaaagtt gcttatgtaa
     7501 gataatatta tatagattat ttttattaat atgtcaattt gtgtgtatat tttaattaag
     7561 ctttaaacat gtttacagga gtagaaacta ttaaaacgtg tgacattgct aagcttttgc
     7621 taataaagta taatatttta tatagtttga aatatttaag aaatatagca aaaaaaggag
     7681 cttggtgatg aataaagaga ttccaaaaaa aattttagta gctgatgata atcctgagat
     7741 tagggaaatc gtagaaatac ttttaactgg tgaaggttat gaagttatta tggcaacgaa
     7801 tggagaagaa gctgtaaact tagtagatag tacgattgat ttgattattt tggatgttgt
     7861 aatgcctgta aaaacaggat ttgttgcatg taatgaaatt agagaaaaaa cgacagcacc
     7921 aatattattt ttaactgcaa aaactcaaga ctctgataaa gttattggat tttcagcagg
     7981 aggagatgac tatttatcaa agcctttttc atattctgaa ctaatttcaa gggttaagtc
     8041 gctacttaga cgttattata tataccaggg aaaggaaaag gaaagagagc caaatatatt
     8101 aaaaacaaaa gagttatgtg tcaatttaga tactcaagat gttacactaa atggagaacc
     8161 tgtgtttttg acaactatag aatatagtat attaattctt atgttgaaaa atagaaaaaa
     8221 agttttttcg tctgaaaatt tatatgaaac tatttgggat gagcagtatt tttatacagc
     8281 aaataataca ataatggttc atattagaaa tttaagaaaa aagttagaaa aagaccaaaa
     8341 aaatccacaa tatataaaaa ccgcatgggg aaaggggtat tatattgatt aacaaaatta
     8401 agccatctaa gttgggagtt atactattga tatatgtagt aatctcagct gcagtggctt
     8461 tcattttaaa tataccattt tactctgctg ttgaatctat agtaaaagat gtatcagaag
     8521 ggaaagtata ttttaaaaga gaagtaaatc aacttatgga taattttcaa acttatgtga
     8581 ataacaatgg tataagagca gatgatggag atgatatagc aaaatggaat agtgataatt
     8641 ggtttgtttc tatgaagata tataaaggaa ataaggtttt ttatgataca ttatactatc
     8701 ctaatgaagt acctgataag agtgaggaaa atgagtttta tagcagtccc atggctagaa
     8761 actatgagat acaattttct gatattaaag ctaatatagt tgtagtagct ttatttagat
     8821 ttagatttca aaattttata gaagcaattt ctattacatt tatggcactt acatttatta
     8881 taacattttt actgttgttt agtagaaaga taaagtacct aaggaaaata gaaatgggta
     8941 taaagatagt agagagtggc agtttaaagt atagaatccc agtaaaaggt aatgatgaat
     9001 tatcatcact tgcatctagt attaatgaga tgagtcatac attggagaat caacttataa
     9061 aagaaaggga gatgaagaat aaaaataaag atatagtaac ttcgatatca catgatgtta
     9121 gaactccatt aacgtcagta atttgttatt tagatttgat taaagaccat aaatacaata
     9181 gtcctgagca attggaacaa tacataaaaa atgtaaggtc taaagcatat caaataaaag
     9241 atttaacaga tgaccttttt acgcattttg ttaattctgg agaggaagtt tcaaaagggt
     9301 atgaaaaaat aaatgctaat gaatttattt ttcaattact tttagatagt tcatatacat
     9361 tggaggagaa aggatttcat ataacaatag aaaatgaact ttataaccaa tatcatattt
     9421 atgtagatgt tacacaattt agaaggatat ttgataattt atgttctaat ataataaaat
     9481 atgctaggaa agataagcct atagtatttt taattaaagt agaggattct aaattactaa
     9541 ttatacaaaa aaatagagta agtaattttt ctaagaatgt agaaagtttt ggaattggta
     9601 taaagaattg tgagaaaata gttgcatatc ataatggaag cataaatgta aattcagatg
     9661 ataaagaatt tgctattgaa atatctattc cagcaaaaga atcataaaaa tttaaattat
     9721 atattgtgta attgctatta tatattgtgt aattgcttat gtaaaattct atgaagcagg
     9781 aagcatgtga ctttagttat gggatgttca atattgtgta cctctaggca agtaacaagt
     9841 ttacttacaa gaccatataa tattattatc ttaaaaaaag gggacataat aatatggttt
     9901 tgacaggagc acattatatt tacattctat ttatggtaat tatattaatt actatgatta
     9961 tgaaaaagga tacaatagta ccatgtatat taggtgtttt ttttatggga ttgttctttg
    10021 aaaaaaacat ctttggtgct ataacagcag tgtttaactc ttttattata tctttaaatg
    10081 agttgggtcc aattatcttg attatagcta ttatggttgc attatctaaa gccctagaag
    10141 ccaataatgc tatacagtat atggtgagac cattttcgag agttataaaa aattctaata
    10201 cagcattttt tgtaactgga tttgttatgt tagttctttc ttggtttttc tggccaactc
    10261 cagctgttgc cttagttgga gctgtatttt tacctgttgc tatgagagct gggctaccag
    10321 caattggtgt tgcagtagca ttaaatttat ttggtcatgg tcttgcctta tctacagact
    10381 ttgttattca aggagctcca agtataacag ctggtgcagc aggtgttgca gtatcatatg
    10441 ttataaatga tggtatgatt ttgttttggg tgatgggaat cgtaaccata tctatggcat
    10501 tttatacatt aaaaagagat attaacaaag gaatgtttag agaagaacta aaaggttttg
    10561 aaagtgaaga agtagaagcg ttcaatggaa aatctaaaat agcaactatt ttagtagctt
    10621 tgggatttct tgctgatata attgctatgt atgtatttga cctaaaagga ggagatgcat
    10681 cagctctttt gggtggaaca gcagtatttt taataataat tataaatgtt ataaattttg
    10741 gcaaagatag tcttgaaaat gtatgtgaga atataattga tggttttgtg tttgggataa
    10801 aaatatttgg agcaattata ccaatagcag catttttcta tatgggtgaa gttgcaccat
    10861 tgacaggtgt atttggaaaa gtattagcac caggttcaca aggtttatta tcagatatag
    10921 gcatagctct ttctcaaaca ataccactta ataaatttgc cgtatcaggt atagaaactg
    10981 tagtgggagc aataactggg cttgatggtt ctggattttc tgggatttca ttagttggtt
    11041 cacttgcctc tgtatttgga actgctataa atgcaagtgt tggtgcatta gctgcattag
    11101 gacaaatcag tggtatatgg gtaggtggag gctgtctagt tccttggggt cttatttcag
    11161 cagcggcaat ttgtggggtt agtccaatag aattggcaaa gcgaaacttt gtcccagtta
    11221 taaccggatt ggttgtaaca accatagtag caatgtttat tatttaataa atcgaataaa
    11281 tctttaattg tataaattaa aaatagatgt gtagctataa tttattataa ttgttttact
    11341 aattctaagc catacatcta tttttattga tatttttatt agtattcttt aataaagtaa
    11401 tatttttcat tatattatac ataacatcta aatataacat ctaaaatact gttatctata
    11461 tttaatatct tgccaaattt tttgatgttt tattgccctg tcccaccaac atatataagc
    11521 tatcacaagt ttttacctat actatcacca aacaaaaatt ctaattttaa tttattattt
    11581 tataacctat attatattaa ctatattagt ttgtagactt tagatgtaat tataaatatt
    11641 aatactccaa gagttcaaat tcatatccta gttttcttgc atttgatata aaatcattta
    11701 aaatttctgt actagttttg gaaactgcat gtagtaacaa gatagaacca tcatgtagat
    11761 tatccattat tttttgcgtt gcttcttcat gtgatggttg tttatcagta tcccagtctc
    11821 tgtatgcaaa actccaaaat acagtcttgt atcctaaatt tttagtcatt gccaagcttt
    11881 tttctgagta ttttcccata ggaggtctaa aaaatttaac catatctttc ccagttacat
    11941 ctttatataa cttttcaaca tcatataatt cgtcattaaa gttttttaga ttgcttgttt
    12001 ttgttggcat agatggatgg gttttactat gatttccaac tatatgtccc tcagaaacca
    12061 ttctttttac taaatcttta ttttctttta tatatggagc tgtaacaaaa aaaactgctt
    12121 taacctggtt ttgttttaga gtgtcgagta tttttgtagt gtatccattt tcataacctt
    12181 catcaaatgt aagatatagt gttttttgac catcttttgt aggtccattg tatagggcat
    12241 catagtcaga aaatttaaat tcaatgtccg tatttacttc tggtgtttta tgcttattgt
    12301 ttggtatata aaaccaatca agagtagtgt tatctaaaga agatacatct aatttattat
    12361 tatcattatt agtagtggct tttgatggtt tatctgttcc gtctgaaact attacattgg
    12421 aagtatcttt accactatct attttttcct tatcttcttg taactgtgtt tccttatttt
    12481 gattttcgtt ttgattgttt tgtgaatttg aacatccaac aataaaaaaa atagaaatag
    12541 aaagtagtgt taaataatgc aatacttttc taaacatttt gaagctcctt tctaaattaa
    12601 taataattgc atataataat aattatatga ttaattacaa ttgcatatag tattattata
    12661 attggaaatt actattaata atagttatat ctttaaaaat aaagtcacaa tagtatgaca
    12721 aagggtgaat aatcaataaa tttaaaaaaa aatgaaaaaa atagttgacc atattatgag
    12781 aagatgttat tataataaat gtgctcaaca agaagtaaca aaataacaag cacaaagaag
    12841 ttaattgaat
//
LOCUS       DAEPID010000099        12616 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.099, whole genome shotgun sequence.
ACCESSION   DAEPID010000099 DAEPID010000000
VERSION     DAEPID010000099.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 12616)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 12616)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..12616
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.099"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     repeat_region   26..446
                     /inference="COORDINATES: alignment:crt:1.2"
                     /inference="COORDINATES: alignment:pilercr:v1.02"
                     /rpt_family="CRISPR"
                     /rpt_type=direct
                     /rpt_unit_range=26..53
                     /rpt_unit_seq="gttttagattaactatatggaatgtaaa"
     gene            638..790
                     /locus_tag="KR257_003304"
     CDS             638..790
                     /locus_tag="KR257_003304"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897477.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0031971.1"
                     /translation="MKNRRKDKRGFSVLLDKEKLDKFDEVLEEKNLTKKEWLEEKIDE
                     ELEQKE"
     gene            910..1724
                     /locus_tag="KR257_003305"
                     /pseudo
     CDS             910..1724
                     /locus_tag="KR257_003305"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009894376.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="toxin Bro"
     gene            1776..1937
                     /locus_tag="KR257_003306"
     CDS             1776..1937
                     /locus_tag="KR257_003306"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454578.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0031972.1"
                     /translation="MCENLLDNMYIEKRKEEYRIKLLKIRETDIDIYNKLESIVYKLS
                     EKKLEKNNK"
     gene            complement(2266..2730)
                     /locus_tag="KR257_003307"
     CDS             complement(2266..2730)
                     /locus_tag="KR257_003307"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454576.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0031973.1"
                     /translation="MDFGEVKSELSDKDLKDNEEALNKYKKYYLKVYKYYSEMDSIKS
                     IQDIEIEQSRLKGQLQKNSNPIFALYISIMAVVFSTTINLTFDLSDITNYFIRMIMTL
                     LFIVLLIFLVNKGILPIAIPYRNNIQFYTTALDVLEDMKKKILRERKYKKRR"
     gene            complement(2866..3183)
                     /locus_tag="KR257_003308"
     CDS             complement(2866..3183)
                     /locus_tag="KR257_003308"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897465.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0031974.1"
                     /translation="MDFGNINLILIGIIVIIGTTIIYLIKPKTAFCSKKYFNKLESIY
                     GNIDKKKTVKLEVLYRYVTGLEYIAIGLFTRRLDITIIAIILVAIITTALYYLIRKKY
                     ITI"
     gene            complement(3466..3762)
                     /locus_tag="KR257_003309"
     CDS             complement(3466..3762)
                     /locus_tag="KR257_003309"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903134.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0031975.1"
                     /translation="MYFKTYILKREVNNKQLEITRSFDLDNLICTATEILKDNEIDLI
                     ITNEVNNVVWRNEKSTPPARECLVIAIEVYWWYTSIFLLYHINYVIKKSYLNRF"
     gene            complement(3781..4194)
                     /locus_tag="KR257_003310"
     CDS             complement(3781..4194)
                     /locus_tag="KR257_003310"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423175.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0031976.1"
                     /translation="MKVKSKRSFIVGIIVCMLCCASLVIYCILKDKRFLISSFLLIVI
                     AIFNFCNAFSRKGIVEELHDSADERDLYLTMKTSHILVKIMNYTLFTFTFLFIIAYSA
                     WKNQSLLVIAITLCVIEIFLFVAYLLINIFLEKKE"
     gene            complement(4178..4411)
                     /locus_tag="KR257_003311"
     CDS             complement(4178..4411)
                     /locus_tag="KR257_003311"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423177.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HBH0031977.1"
                     /translation="MKTKVREFRTNMGLTQQQLADLVHVSNRTIISIEKEQYSPSLML
                     AYRMAQVFGTTIEELCCLKENKEMEDKKHESKE"
     gene            4630..5004
                     /locus_tag="KR257_003312"
     CDS             4630..5004
                     /locus_tag="KR257_003312"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430377.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="BlaI/MecI/CopY family transcriptional regulator"
                     /protein_id="HBH0031978.1"
                     /translation="MKISKLPEAELKVMRYICEANKVLTSRELVAAMEEKYEWNESTT
                     FTVLKRLERREFLSTEKIGKLTHYNILVKEKKYLRFETKEFLKNIHKNSISSLMSALH
                     GEDDEVDEDKLSELEEYFKNLK"
     gene            5616..6308
                     /locus_tag="KR257_003313"
     CDS             5616..6308
                     /locus_tag="KR257_003313"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423181.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HBH0031979.1"
                     /translation="MYNILVVDDDKEIVDSIEIYLKSEGFKIYKAYDGMKALEIITEN
                     DIHLILMDIMMPKLDGIKATVKIREERNIPIILISAKSEDTDKIIGLNIGADDYITKP
                     FNLLELIARVKSNLRRYVTLGNYEDTCKEILKSGALELNTLTKEVKIDGENIKMTPIE
                     YKIIELLLENKGRVFSIDEIYEKVWNEESFNSENTVAVHIRRIREKIEINPKEPRFLK
                     VVWGVGYKIEKF"
     gene            6504..8564
                     /locus_tag="KR257_003314"
     CDS             6504..8564
                     /locus_tag="KR257_003314"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897457.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sensor histidine kinase"
                     /protein_id="HBH0031980.1"
                     /translation="MEKYRVLKLVSLIIISISFPLTILLVTIGLAEPKYNIQKTSTKS
                     GIFDISDDFYDSNIFDEGTMASLLPKFKLSVGGKLTSKEKGKFQQEGKSIDLSSSDSE
                     YDKIMINEQASEEYLSYLKNIKVYVINTYTGVFYTNTSYASLYDFKQKTKSYCNVEII
                     NKIGKSSYIKTINGEKFELNNLSLELNEVDEGFEAYVSFPEEPTIEDGIVYTNFQIFK
                     QATEKVRLFFVASLSLAIICLLSIILYIKIKGEVLKRNNVFLLIYSKIPMEFNVILVS
                     ISIAILTIYALAVSYHIDVIALVSLSLLIVSNNIFFINVQLSYLENKMCIFKTSIIVR
                     VILWLIKTVREVSNAIKKVSLARKVIVIVIISLALIMAISTRSIGMGLLFSICIFLGF
                     TIYITKRLSYLSYVIEGTERIKKGELDYKIKITGNDNFTSLAENINNIGEGLDRAIEE
                     QVKSERMKSDLITNVSHDLKTPLTSIINYVDLIKKEESIQPEYINDYINVLESKSKRL
                     KLLIEDLFEASRVSSGNIELQISKIDLVQLLRQSIGELEEKLSKNNLYLKLNVPNDKV
                     YIWADGRRMYRVFENLLSNIAKYSLEETRVYIDVYDYGENVKVTMKNISSYELNFDPS
                     EIMERFKRADESRNTEGSGLGLAIARDLVALQGGKFYIEIDGDLFKANLEFQKYEEEI
                     TNME"
     gene            complement(8770..9093)
                     /locus_tag="KR257_003315"
     CDS             complement(8770..9093)
                     /locus_tag="KR257_003315"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454564.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AzlD domain-containing protein"
                     /protein_id="HBH0031981.1"
                     /translation="MNNNYIFFIIIGMYIVTYLPRVLPMLIFSKKEMPDFLKKIMKFI
                     PVAILTSLTAKDVFFNGDSLYLSIANPKIISFMIVLLVAYKFKSIGISIITGVISIYL
                     FGIIL"
     gene            complement(9086..9787)
                     /locus_tag="KR257_003316"
     CDS             complement(9086..9787)
                     /locus_tag="KR257_003316"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430383.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AzlC family ABC transporter permease"
                     /protein_id="HBH0031982.1"
                     /translation="MERTQQLKESFIASIPIFLGYIPIGIVGGILLQKSGLSPFQIAL
                     MVTLVFGGSSQFIAASMISTGASVTSIVLTTFIVNLRHFLMSSNLNMYIKNKSPKFIL
                     PFCHTITDETFAVNYEKFTAGNWSDRNAIYLNFFCLISSVLANFIGAFLGESISIDSS
                     ISGFILTSMFIALIVSQIKNKIYIVVFISSIIISVILYALFKSNLVIIVASILASLIG
                     FFIEESYCKKEESYE"
     gene            complement(10065..11450)
                     /locus_tag="KR257_003317"
     CDS             complement(10065..11450)
                     /locus_tag="KR257_003317"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893561.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PLP-dependent aminotransferase family protein"
                     /protein_id="HBH0031983.1"
                     /translation="MPINSFENYPMNWKPKRPSKGQILYKALVEQLEQDINNGFLLPG
                     TKLPPQRELADFLDVNVSTISRAFKICEKKGLISGVTGSGTFVSYDTRSNLFLMSSNN
                     KITFIEMGTMNPDFTLEEMNTLFKHIIKEIDFKTIFQYGQRDGAKWQKEAIAKLIYKA
                     GLETTSDSLLPASGGQNAIVAILAGLFQHGDRIGVDPLTYPGIKTAAKMLGIQLIPIK
                     QEDNEISEEGLLYACKNENIKGLYIIPDYQNPTTHIMSQNGRKMIANIASKYNLIVIE
                     DAIHSLLNETHLNPVASYLPNQTIYITSLSKIIAPSLRLAYISTPKQYREALSSALYN
                     INLSQSYFLTEIAYRMITSGEADKLINARRKSARRRNKIINQYLSGYNLLGNEECIFR
                     WLILPDGIMAEKFEIQALKEGVQVYASERFAVGKEKPISAIRIAVCATESTEELKAGL
                     SVLKRLLEEKK"
     gene            complement(11896..12318)
                     /locus_tag="KR257_003318"
     CDS             complement(11896..12318)
                     /locus_tag="KR257_003318"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423210.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3284 domain-containing protein"
                     /protein_id="HBH0031984.1"
                     /translation="MNTFKTEVLLKYSAKDIFNIFTKSARLNFPNFNEKKAVGTFVQQ
                     KNNKRFKVEITNFEKNRVYEIKTSNKRESTITRYELVHIDLENTKLIFIESESKRNIF
                     GKINSALVRVLFGKRQPEEFNKFIKKLEMELENNSVNL"
BASE COUNT         4925 a         1438 c         1804 g         4449 t
ORIGIN      
        1 tatgaagaaa tttactacaa aatttgtttt agattaacta tatggaatgt aaaaactttt
       61 ttcatcctcc caaacctctt gttcgctgtc gttttagatt aactatatgg aatgtaaaaa
      121 agaaaataag tttaaaaaaa ggtttcatta ttatatcgtt ttagattaac tatatggaat
      181 gtaaaaccaa ttatgtacag tttagttact gtgttaagtc ttgttttaga ttaactatat
      241 ggaatgtaaa atccttttat aaatatcttc tgacatgtgt atatgcttgt tttagattaa
      301 ctatatggaa tgtaaatcgg ctacaacggt ataaattaaa tttagcaggg tacattttag
      361 attaactata tggaatgtaa attgctgtga tttcaataat aaaacaatta ataattgtgt
      421 tttagattaa ctatgtggat tcaaaattaa ataaacaaag aaagcactta caaatatgta
      481 ggtgctttta ttctgctcaa aattggtcgg ttgggtaaaa taattagaaa aagttagtaa
      541 aaacctattg actgtaactc gttacaatat tgttattaat gtaacgagtt acagaaaaga
      601 ggtgaataaa atagcaacta aaagtagggc agagtatatg aaaaatcgtc gaaaagataa
      661 aagaggtttt agtgtacttt tagacaaaga aaagttagat aaatttgatg aagtgttaga
      721 ggaaaagaat ctaaccaaga aagaatggct agaagaaaaa atcgacgagg aactggaaca
      781 aaaggaataa aaaataaggg tcactcccac cgaccaaagt ttgagtaacc cctatgacgt
      841 atactatcgt atatcaatta tagtatatgt cattccttaa aaaaatcaat tattaaggag
      901 tgtaatatta tgaaaaatga attaatgatg tttgaaggaa aagagattga agtatttgaa
      961 tttgaaggaa gaattttatt caactcaaaa gatgtagtaa actgtttaga cataaaaaat
     1021 gttaatgaga atataagact tatgaatgaa aagcaagttg taaagttaag aaattcggat
     1081 atcagtaata ctgacatccg aaaacttaat aatgctggag aaaattttct tactgaaagt
     1141 ggagtgtata aattaatctt taaatcaaga aaagaagaag ctgagagatt ccaaggctgg
     1201 ataagtgatg aagttttacc aagcataaga caaactggtg catacataaa taataatgca
     1261 ataccgaaaa gttgagagaa aaagcaagtg agattgaaaa attacagttg gtttataaca
     1321 gtacatctat gttaaaagaa ttgctagatg atgcaggctt tgacaataaa tcaaaactat
     1381 taacagctaa aacattatat aagaaagcag gaattgattt accaatagag ataaacgaag
     1441 aagaacatta ttttgataca aaacaaatag catctaaact gaaaatatat tctaagagta
     1501 ataaaccagc tcagatggca gtttgtgaga ttattaaaaa gattgattta gaagatggtg
     1561 aagttaaagg tgtttgggaa attaatggtt cttggactgg tactgtaaat aaatatacaa
     1621 agagtgtaat agataaggtg agaacttgga tagaggaaaa taatagacct accaagattg
     1681 caggtgagaa gaagaattat tatgtatttt acaaaattga gtaaatttat cagttgtatt
     1741 aaataattta gtttagtttt ggggggatta atacaatgtg tgagaattta cttgataata
     1801 tgtatattga aaagagaaaa gaagaatata gaattaaact tttgaaaata agagaaacag
     1861 atatagatat atataataag ttagaaagta tagtatataa actttctgag aaaaaattag
     1921 agaaaaataa taaatagaca tataaagcac ttggatattc tactgtttca agtgctttgt
     1981 ttggtataaa atggtataat ggagatagag aattatatta acccaaaaat ggagaaaata
     2041 gagaagatga tttagttgac gctttatcag taggagtact tgcaggtaag acagaatctc
     2101 tagtactatt agttggaaat ggaataagtg atactcaaaa aagtttaata aataaaagag
     2161 aatttagaaa tataactcaa attggtggaa atggaaatga gaaagcattt agtgaagtag
     2221 aaaacttagt taaatagatt agaaggtagc aactagagtt ggttgttacc ttcttttttt
     2281 atactttctc tctctaagta ttttcttttt catatcttct aatacatcta atgcagtagt
     2341 ataaaattgt atattatttc tataaggtat agctattgga agaatgccct tgttaactaa
     2401 aaaaataaga agtacaataa ataaaagtgt cataatcatt ctaataaaat aattagtgat
     2461 atctgataaa tcaaatgtta agttaattgt tgtagaaaat acaacagcca taatagatat
     2521 atacaaagca aaaatggggt tactattttt ttgtaactgt cctttaagcc tagattgctc
     2581 tatttctata tcttgaatac tttttatgga atccatttca ctataatact tataaacttt
     2641 taaataatat tttttatact tgtttaaagc ttcttcatta tctttaaggt ctttgtcact
     2701 taactctgat ttaacttccc caaaatccat aaaatccctc ctacaatgtt atataatata
     2761 ctttaattta tagcatattt aagaacttat atcagcaatt tgtcgaacga ttttagctaa
     2821 aaatagagta taatgatagg cttattattt ataagatatt attttttata tagttatata
     2881 tttctttcta attagataat ataatgctgt tgttataatg gctactaata ttattgctat
     2941 tattgtaata tctaatcttc ttgtaaataa gcctattgct atatactcaa gacctgttac
     3001 atagcgataa agtacttcta gtttaacagt ttttttctta tctatatttc catatattga
     3061 ttctaattta ttaaaatatt ttttactaca aaaagcagtt ttaggtttaa ttaaatatat
     3121 tattgtagtt cctattataa ctattattcc aataagtata agattgatat ttccaaaatc
     3181 catagcagat acctcctatt aaatttgctt ttcttaatca aagtatatca gtaacacaag
     3241 tacaaagagc atctaaaata ttacaaatat taacaggata gataaaacta tagtaaaaat
     3301 tgtaataata aagcgaacga aaattatcat actaaaacat aagacatgtt ataattgtat
     3361 tagatagaag attaacatac accaaagcac tccttacaat aaagagtgct tatttttttg
     3421 aaattcatca atatataaac tatcaagaac cttattcaac acaccttaaa atcgatttaa
     3481 atagctcttt ttgataacat aatttatatg atataataaa aaaatagaag tgtaccacca
     3541 atacacttct atagctataa ctaagcattc tcttgctggg ggagtgcttt tttcatttct
     3601 ccaaacaaca ttatttactt cattagtaat tatcaaatca atctcattat ctttcaaaat
     3661 ctctgttgca gtacaaatta gattatctaa gtcaaaactt cgagttatct ctagttgttt
     3721 gttatttact tctcttttta gtatataagt tttaaaatac atttatatca ccccttgtat
     3781 ttactctttt ttctctaaaa atatattgat aagtaaatat gcaacaaata aaaaaatctc
     3841 aatgacacat agtgttatag ctataactag aagtgattga tttttccatg cactataagc
     3901 tatgatgaaa agaaatgtaa aagtaaataa tgtataattc ataattttaa ctaagatatg
     3961 acttgttttc attgttaagt acaagtctct ttcatctgca ctatcgtgta attcttcaac
     4021 aatgcctttt cttgaaaaag cattacaaaa attaaagatt gctattacaa ttaaaagaaa
     4081 tgatgaaatt aggaatcttt tatcttttaa aatgcaataa ataactaaac tagcacaaca
     4141 taacatacaa actataatac ccactataaa acttcgttta ctctttactt tcatgttttt
     4201 tatcctccat ttctttattt tcttttaaac aacatagttc ttcaatcgtt gtaccaaaca
     4261 cttgtgccat acgataggca agcataagag aagggctata ttgctctttt tcaatagaaa
     4321 taattgttct gtttgataca tggactaaat cagcgagttg ttgctgtgtt agacccatat
     4381 ttgttcgaaa ttctcgtact tttgttttca ttccataacc tctttctata tgaagctaac
     4441 ttcatgtgaa gttagcttca taatatccta aaatgagtaa aatgtcaatc tcattagata
     4501 agtattataa aacctaaaag aataatatgg taaaaattgg atggaattat ttaccttaat
     4561 tctcttgttt gtaaaacttt attgatatag aatttaacat atacataaat cggcaaaggg
     4621 gcgcgaatta tgaaaattag taaattacca gaagcggaat taaaagttat gagatatatt
     4681 tgtgaagcta acaaggtatt aacttctagg gaattagttg ctgcaatgga agaaaaatat
     4741 gagtggaatg aatcaactac atttacagtt ttgaaaagat tagagcgaag ggagttttta
     4801 agtacagaga aaataggcaa acttacacat tataatatac tagtaaaaga gaaaaaatat
     4861 ctaaggtttg aaacaaagga atttttgaag aacatacata aaaattcaat ttcaagttta
     4921 atgtcagcgt tacatggtga agacgacgaa gtggatgaag ataaattaag tgaactcgaa
     4981 gaatatttta agaatttgaa ataagaaaat gacaaattga tacataataa ataaaatgaa
     5041 ggtatgaaat tataactttt tctaccttca ttttgtttat tattctgaac atgttaagaa
     5101 aatgaaataa gtttgtattt tagttatata aattttaata gaatatgtac agtatatagt
     5161 agatagaatg tataaaaata gaatttaaat aagtagctat tattgcagtg aaatgaatgt
     5221 ttctaagtat atttgggtgg aagaatggtg gaagaaaatt agtgaaatgt aattcttcca
     5281 ccattcttcc acccaaaaaa taaaaactgt tcaataagaa ttaatataca tcaattcagc
     5341 tgaatgcaat caaaatactt aaatgaaagt aatctgaaaa caacataatt caaatcaatt
     5401 tattcaaata aacctcaatt tatcttaaat cttaagaaat atttaagaat taggataata
     5461 ttttcttaag atttatattt tattatatag ttataaggga aagttacaaa aatgtaagcc
     5521 aaagtaatat aacaatttag tcattgttga gaaagggagt gaaagatatt gtataatata
     5581 gataagtatt attatacaat agaggaagtg aaaatatgta caatatatta gtagtagacg
     5641 atgataaaga aattgttgat tcgatagaaa tatatcttaa atcagaagga tttaaaatat
     5701 ataaagcata tgatggaatg aaagctttgg aaataataac agagaatgac attcatctaa
     5761 tactaatgga tataatgatg cctaaattag atggaatcaa agcaactgta aaaatacgag
     5821 aagaaagaaa tattccaata attttaattt cagcaaaaag tgaagataca gataaaataa
     5881 taggattaaa tattggagct gatgattata taacaaagcc atttaatcta ttagagctta
     5941 tagctagggt taaatcaaac ttaagacgat atgtaacttt aggtaattat gaagatacat
     6001 gtaaagaaat tctaaaaagt ggagctttgg agttaaatac actaacaaaa gaagttaaaa
     6061 ttgatggtga aaacataaaa atgactccaa ttgagtataa aataattgaa cttcttttag
     6121 aaaataaagg acgagttttc tcaatagatg agatatacga aaaagtatgg aatgaggaaa
     6181 gttttaattc agaaaataca gtagcagtac atatcagacg aataagagaa aagattgaaa
     6241 taaatccaaa agaaccaaga tttttaaagg tggtgtgggg agttggttat aagattgaaa
     6301 aattttagtg gaaaaattat aaaagaaaag agtttaatat ttaattgcat tttgatttta
     6361 gtcattttta catttacaca aatgttagga attttaatat gttttaattt tttctctgag
     6421 agtttaattt actctatggg gattatgctt ttcttaaact ttattttata taaaatactg
     6481 acaatgtaga tgaggtgggc aacttggaga aatatagagt attaaagtta gtttcattaa
     6541 tcataatatc tatctcattt ccattaacta tattgttggt gacaatagga cttgctgagc
     6601 ctaaatacaa tatacaaaaa acttctacaa agagtgggat ttttgatata tctgatgatt
     6661 tttatgatag taatatattt gacgaaggaa caatggcaag tctattaccc aagtttaagc
     6721 tatctgtagg tggtaaatta actagtaaag aaaaaggtaa attccaacaa gaaggtaaaa
     6781 gtatagattt aagtagtagt gattctgagt atgataaaat catgattaat gaacaagctt
     6841 ctgaagaata tttaagttat ctaaaaaata taaaagtgta tgttattaat acatacacag
     6901 gagtatttta tacaaatacg tcatatgcta gtttatatga ttttaaacaa aaaactaaga
     6961 gctattgtaa tgtagagata ataaataaga taggaaagag ctcatatatt aaaacaataa
     7021 atggagaaaa atttgaactg aataatctga gtctggaact aaatgaagta gatgaaggtt
     7081 ttgaggcata tgtatctttt ccagaagagc caactataga agatggaata gtatatacta
     7141 attttcaaat atttaaacaa gctacagaaa aagtaagatt attttttgta gctagtttaa
     7201 gtttagcaat tatatgttta ttatctataa ttttatatat caaaataaaa ggtgaagttt
     7261 taaaaagaaa taatgtattt ttactaatat acagtaagat acctatggaa tttaatgtaa
     7321 tattagtatc tatttcaatt gcaattttaa ctatatatgc tcttgctgta tcttatcata
     7381 ttgatgtaat tgcattagtt tctttatctt tactgatagt atcaaataat atatttttta
     7441 taaatgtgca attgagctat ttagaaaata aaatgtgtat atttaagaca agtattatag
     7501 taagagtgat tttatggtta ataaaaactg taagggaggt cagtaacgct ataaagaaag
     7561 tatctttagc aaggaaagtt attgttatag tgataatatc tttagcttta atcatggcaa
     7621 ttagcactcg aagtataggt atgggattac tgttttctat atgtattttt ttaggattta
     7681 caatatatat aactaaaaga ctttcatatc ttagttacgt aatagaaggt acagaaagaa
     7741 taaaaaaggg agaattagat tataagataa aaattactgg gaatgataat tttacgtctt
     7801 tagctgaaaa tataaataat attggagaag gtcttgatag agctatagaa gagcaagtaa
     7861 aaagtgaaag aatgaagtct gaccttataa caaatgtatc tcatgatttg aaaactccac
     7921 ttacttctat aataaattat gtagatttaa ttaaaaaaga agaatcaata caaccagagt
     7981 atataaatga ttatataaat gtacttgagt caaagtcaaa aagactaaaa ttattgatag
     8041 aagatttatt tgaagcgagt agagtaagta gtggcaatat agaattacaa attagcaaga
     8101 ttgatttagt gcaactatta agacaaagta taggtgaact tgaagaaaaa ttatctaaaa
     8161 ataatttata tttaaaatta aatgttccaa atgataaggt gtatatatgg gcagatggaa
     8221 gaagaatgta tagagtattt gaaaatcttt tatctaatat agcaaaatat tccttagaag
     8281 aaactagagt ctatattgat gtatatgact atggtgaaaa tgtaaaggta actatgaaaa
     8341 atatatcttc ttatgaatta aattttgacc caagtgagat tatggaaaga tttaaaagag
     8401 ctgatgaatc aaggaatact gaaggaagtg gattagggct tgctattgca agagatttag
     8461 tagctttaca aggtggaaaa ttttatatag aaatagatgg agatttattt aaagcaaatt
     8521 tagagtttca aaaatatgaa gaagaaataa caaatatgga atgagatagt atttaagtat
     8581 atatattttt tttactgtcg aaagctttta ttataatata ttagaatatt tacagtagag
     8641 aatgaagagt aaaaacagag taactttaag tcactctgtt ttttatttaa aatcaataat
     8701 ataacaactt aaattaaaat tgtacacata gttttaaaat aacttataca ataaaacatt
     8761 atccaaatat cacaagataa ttccaaataa atatatagat atcactcctg taataataga
     8821 aataccaata gatttaaact tatatgcaac aagaagtaca atcataaaag atataatttt
     8881 agggttagct atagataaat atagactatc tccattaaaa aatacatctt tagcagttaa
     8941 ggaagtaagt attgctacag gtataaattt catgattttt ttcaaaaaat caggcatctc
     9001 tttttttgaa aaaattaaca taggaagcac tcttggtaga tatgtaacaa tgtacattcc
     9061 aattataata aaaaatatat aattattatt cataagattc ctccttttta cagtaagatt
     9121 cttctataaa gaaaccaatt aaagatgcta aaattgatgc aactattatt actaaattgc
     9181 ttttgaataa tgcatataaa ataacagaaa taatgattga tgatataaat actacaatat
     9241 aaatcttatt ttttatttga gaaactatta aagctataaa catagaagtc aatatgaagc
     9301 cagaaataga actgtctata gatatacttt ctcctaaaaa tgctccaata aaattagcta
     9361 aaactgatga aattaagcag aagaaattaa gataaatagc atttctatca gaccaatttc
     9421 cagcagtaaa tttttcataa ttaactgcaa aagtttcatc tgttatagta tgacaaaatg
     9481 gcaatataaa ttttggactt ttatttttta tgtacatgtt caaattagaa ctcattagaa
     9541 aatgtcttaa gttaactata aatgtagtca aaacaataga tgttacactt gcaccagtag
     9601 aaatcattga agctgcaatg aattgagaac ttcctccaaa tactaaagtt accattagtg
     9661 ctatttgaaa aggtgaaaga ccagattttt gtaatagtat tcctcctact atacctatag
     9721 gtatataacc taagaatata ggaattgaag caataaagct ttcttttaat tgttgagttc
     9781 tttccacaat aaatcactcc ttttgtatta aatgtattaa agtattagta aaacagaaaa
     9841 atagattaat tgtataattg caattataat taaaaataaa tttggattaa tatataaaat
     9901 actatacaac aaatagataa tcttaaacgg ttattaaatt ttatctattt gttattatga
     9961 tgtaataata catattaatc tctataagtt aattactatc tggtgtaatt ttattttaac
    10021 aacaaaaaaa aatacacaca attaaaatat tgtgtgcaat acaattattt tttctcttct
    10081 aatagtcttt ttaatacgct caaaccagct ttaagttctt ctgtactttc tgtagcacat
    10141 acagctattc ttattgcaga aattggtttt tcttttccaa cagcaaaacg ttcagaagca
    10201 tagacttgta caccttcttt aagtgcttgt atctcaaatt tttctgccat tattccatca
    10261 ggtagaatca accatctaaa tatacattct tcatttccca aaagattata tccagataaa
    10321 tattgattaa taatcttgtt tcttcttctt gcagatttac ggcgtgcatt aattaattta
    10381 tcggcttcac ctgatgtaat catgcgataa gcaatttctg ttaaaaaata agattgagat
    10441 agattaatgt tgtataatgc gcttgataat gcctctcgat actgtttagg tgtagagata
    10501 tatgctagcc gtaaactagg tgcaataatt tttgataaac tcgtaatata aattgtttga
    10561 tttggcagat aggaagccac tggatttaaa tgtgtttcat taagtaaact atgaatagca
    10621 tcctcaataa caattaaatt gtatttagat gcaatatttg caatcatttt tcgtccattt
    10681 tgtgacatta tatgtgtagt tggattttga taatctggta ttatgtatag acctttaata
    10741 ttttcatttt tacaagcata taatagtcct tcttcactaa tctcattatc ttcttgttta
    10801 attggaatta gttgaatccc aagcatttta gctgctgtct ttattccagg ataagttaat
    10861 gggtctacac ctattctatc tccatgttga aacaaaccag ctaaaatagc aacaattgca
    10921 ttttgtccac cacttgcagg aagtaagcta tctgatgtag tttcaagccc agctttataa
    10981 attaatttgg caatagcttc tttttgccat ttagcaccat ctctttgtcc atattggaat
    11041 atagttttaa aatctatttc cttaattatg tgtttaaaca aagtattcat ttcttctagc
    11101 gtgaaatctg gattcattgt gcccatttca ataaatgtaa ttttattatt actggacatc
    11161 aagaatagat ttgaacgtgt atcataagat acaaaagttc cacttcctgt aactccactt
    11221 attagacctt ttttttcaca aattttaaaa gctctagaga tagtactcac attaacatct
    11281 aagaaatctg ccaattcacg ttggggtggt aatttagtac ctggtaataa aaatccattg
    11341 ttgatatctt gttctagttg ttctacaagc gccttatata atatttgccc ttttgaaggt
    11401 ctctttggtt tccagttcat aggataattt tcaaaagaat taattggcat aagttttcac
    11461 ctcacattat taatttgatt ttttctttat ctaaaacaat aaattctaaa gatacaaata
    11521 aaaactgata ggaaataatt ctatcagttt ttgtctttta attgatttca aatcttccta
    11581 taatttttat accttcttta tcataaagag ggattgtttt tttaaatata ttaaaatttc
    11641 tttttcttgt atataaaaca gcttcttctg gtgtctttgg ttggttatca caatcgtaca
    11701 aatttctttt ttttaactaa aagcaataat acataaaatt attattgcta atgatactct
    11761 taatgtggta tatagtcata gtgtcacatg tctatcaata gttttttcag taattattgt
    11821 aacgaatagt aggactcata aaatacttag aaatatgttt ttagataaat tttaaatata
    11881 taatctaact tatatctata aattaacact attattctcc aattccattt ctagtttttt
    11941 tataaattta ttaaattctt ctggttgcct ttttccaaac aatactctta caagagctga
    12001 attgattttt ccaaatatat tcctcttgct ctcactttca ataaaaataa gttttgtatt
    12061 ttctaagtca atatgtacta attcatatct agtaatagta ctttctcttt tattgcttgt
    12121 ttttatctca tatactctat ttttttcgaa attagttatt tcaaccttaa atcttttatt
    12181 atttttttgc tgtacaaatg ttcctactgc ttttttctca ttaaaattag gaaaatttag
    12241 tcttgcagat tttgtaaata tattaaatat gtcttttgca gaatatttta ataaaacttc
    12301 agttttaaat gtattcatat cgttttccct tctgtatata aatttaatat ttataagtta
    12361 atttttaagt taaaatagta taatatgcca tattaaatca tgttaaaact atttatatag
    12421 ctaaaatctt acctatataa gtatgtatac tatcatataa aaataaaatc ttaaaataga
    12481 aagggttaaa aacacagttt attataattt ttattgttga gtagatacgt actattatat
    12541 atgattgagc aagtttttca atcataaatt tataaagtat tttgcattaa aatttaaaca
    12601 aagaattaaa ttattt
//
LOCUS       DAEPID010000100        12605 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.100, whole genome shotgun sequence.
ACCESSION   DAEPID010000100 DAEPID010000000
VERSION     DAEPID010000100.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 12605)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 12605)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..12605
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.100"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            <1..1452
                     /locus_tag="KR257_003319"
     CDS             <1..1452
                     /locus_tag="KR257_003319"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009906093.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="EAL domain-containing protein"
                     /protein_id="HBH0031985.1"
                     /translation="EVDIKVLILILLTLFSINVFISYLKIKLYEDKINLGLINNSDKF
                     INITKDENFLKHVQNYIISNEKENCVMACFDLCRLKLINDIYGYELGDEVLNNILSNL
                     KNYFGKEAIYGKLKSDVFVLIIKLENREQKIPYLVNLIKNKIVILSQIDSFKMDINIE
                     ASIGIYKFNNNEIDIKKAIDNADMARLKSKGLKHIEYVEFDNAMEEEIQSIMKIERDL
                     FLAIKNKEFVIHYQPKVDSSTGNIIGSEALIRWLHPSLGMVGPNKFIPIAEKNGLINN
                     IGRWLIQEVFITINKWISEGINVLPVSINLSRVELYKNDLVDFFKLMFNTYNIPKELI
                     ELEITETTALRDVKFISERLYEIKSLGMNISLDDFGVGNSNFINLKGIPLDIIKIDRS
                     LILDIVTNTKTKFMVKAIVNLSHDLNVTVICEGVEDMHQVKVLSELGCNFIQGYVFFK
                     PLDEMNYKKLLTDGSYINLKDTLLDKCMTVEEE"
     gene            1455..1853
                     /locus_tag="KR257_003320"
     CDS             1455..1853
                     /locus_tag="KR257_003320"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426473.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Rrf2 family transcriptional regulator"
                     /protein_id="HBH0031986.1"
                     /translation="MISEDVDYSIRIIRAIFNNGEDKPIDAKMILKSEDIPILTLYRL
                     LRKLCANNILTFNKEDGKTYMLNVSLDTISLRTIVEVIDGKIYINKCTRYVSNCSNCL
                     KGCKVNRELLEIEKEIYKLLSRKSIRQILE"
     gene            1893..3626
                     /locus_tag="KR257_003321"
     CDS             1893..3626
                     /locus_tag="KR257_003321"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422891.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="N-6 DNA methylase"
                     /protein_id="HBH0031987.1"
                     /translation="MDDISQDNFLLSKEYENSLDVDTKKASGIYYTPKIIVDYIVKKT
                     LKNHDIIKNPYPRILDISCGCGNFLLEVYDILYDLFEENIYELKKKYDENYWTVDNIH
                     RHILNYCIYGADIDEKAISILKDSLTNKKVVNDLDESDIKINLFCCDSLKKKWRYKFD
                     YIVGNPPYIGHKKLEKKYKKFLLEKYSEVYKDKADLYFCFYKKIIDILKQGGIGSVIT
                     PRYFLESLSGKDLREYIKSNVNVQEIVDFLGANIFKNIGVSSCILTFDKKKTKETYID
                     VFKIKNEDICINKFETLEELLKSSKFEHFNINQRLLSDEWILVNKDDETFYNKIQEKC
                     KYSLEDIAISFQGIITGCDKAFILSKDDVKLNLVDDKFLKCWIKSKNINKYIVDKSEY
                     RLIYSNDIDNENTNKRILDEIIGLYKTKLENRRECKSGIRKWYELQWGREKLFFERKK
                     IMYPYKSNENRFAIDYDNNFSSADVYSFFIKEEYLDKFSYEYLVGILNSSVYDKYFKI
                     TAKKMSKNIYDYYPNKVMKIRIFRDNNYEEIENLSKQIISILLNKSIDKGKVEKLQIK
                     MDNLIMDSLGI"
     gene            3858..5069
                     /locus_tag="KR257_003322"
     CDS             3858..5069
                     /locus_tag="KR257_003322"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422893.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="patatin-like phospholipase family protein"
                     /protein_id="HBH0031988.1"
                     /translation="MKGLVLEGGGTKGAYQIGAYKALRELGIEFQGVTGTSIGALNGA
                     YIIQNDIEVMEDIWLNYDYTHFMNIDRETYERFKNVDFTTKNLNAVFELINKARKNEG
                     IDISPLRQLMETTLNEDIIRKSKKDFGLVTVWWDKKINPYPLYIEDIPKGRLIDYLIA
                     SSSLPIFQTNMMDDKLYLDGMFCDNMPIGLLEDKGYEDVVVIRLIDDFIGKMNLNRHQ
                     NINIKTIIPSEYLGGSLNKDRDNVEKNIRLGYLDTMKAYERCTGIKYYFDVEYKYNEE
                     YCFDKFRSMSNETIQYICNLLNIKRDASLRTVMESVIPKLGEVLGLPKDFSYKDLFYC
                     IYEKKLEENNINRIKLYDFNKVIDVVNTNIDSNRNLASNFEVRPKISIKKNKNTKLLT
                     NCIIKDIKNQS"
     gene            5262..5522
                     /locus_tag="KR257_003323"
     CDS             5262..5522
                     /locus_tag="KR257_003323"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422895.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HPr family phosphocarrier protein"
                     /protein_id="HBH0031989.1"
                     /translation="MEKVVSIKNASGLHARPAGMFVKKAAEFKSTVEVVAKDKTVNAK
                     SIMGIMSLGLAQGEELKLVVNGEDEEVALAAMVELVESGFGE"
     gene            5876..7588
                     /gene="ptsP"
                     /locus_tag="KR257_003324"
     CDS             5876..7588
                     /gene="ptsP"
                     /locus_tag="KR257_003324"
                     /EC_number="2.7.3.9"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003431795.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphoenolpyruvate--protein phosphotransferase"
                     /protein_id="HBH0031990.1"
                     /translation="MAYKGIGASPGVALGKALVVEHSELVIEKKSIDNVEAEIAKLED
                     AVAVSKEELVKVKEKASEELGAEEAEIFEAHLLVLEDPELIGSAIDKIKTESVNAEYA
                     LNEIKEMFVSMFESMDNEYMKERAADIKDVTNRILRHILGIKVVDLSALSEEVVLIAH
                     DLTPSDTATMNKKMVLGFLTDIGGRTSHTAIMSRTLEIAAIVGLNDITSKVKDGDFVV
                     FNGDTGEVIVNPDEETINKYTELKAKYEDERKALQLLKGKPSVTLDGKHVELAGNIGT
                     PNDIEGLIKNDAEGVGLYRTEFLYMDRDSFPTEEIQYEAYKAVLEGMDGKPIVIRTLD
                     IGGDKELSYLSMEPEMNPFLGYRAIRLCLDRKDIFKTQLRALYRASVHGRLRIMFPMI
                     SSLEELLQAKEVVKEVLAELDSEGVAYAKDVEIGMMIEVPSAAVISDVLAKHVDFFSI
                     GTNDLIQYTCAVDRMNQKISYLYNQFNPAVLRLIKTVIDNAHKEGKWAGMCGESAGDQ
                     KMIPILLGMGLDEFSMSPISILPARKLITSVKESDMKKLADDVLNMGTAEEIKSYIEK
                     TFNI"
     gene            7911..9461
                     /locus_tag="KR257_003325"
     CDS             7911..9461
                     /locus_tag="KR257_003325"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861669.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GGDEF domain-containing protein"
                     /protein_id="HBH0031991.1"
                     /translation="MRYKKRNIDKSSELSFQSLAKYFITFYIVIILIILSMFCINTIW
                     VMKKDNQDLLSTTSNRIEDRVGETIKLLNSLSKDNYIIDNSVNGIDKSKELSMYSDEF
                     GYMMICFVDKNIIVWDEEGGNISLAGRDYMQKLFATKKYQVTDSFAAGADGKTLNYTI
                     ASPIIKNGNVDGCVFAAIYFDEIKDILKQGKGQQQQNFILFGSENQIMNLTSDETAYG
                     EKYMKLSQKTKYLGTNAKKVEKDMFNNKSGDYWAFENGKLYFMSYKPIKNTNWSLFCK
                     VNFLDIFALNLIPMGAILSVITLVFIILICMEKSFMKKRMEVIDMLLGSVQELEKRIY
                     QTERPSEVDFKEIIQLTSKGLTDGLTGVVTRTVFFDQIYNRVEMEENDKLSVISFVDL
                     DDLKCINDLYGHEIGDMVLKNVGYVLREYEIKYNGLIGRYGGDEFVMLLSGFTSREEV
                     EDLLDEIAIRLHTEVLTDDGIIQTHCSVGAVVCSVKDNKDIDNLLKQADEALYYVKRN
                     GKGNYHLV"
     gene            9487..12189
                     /locus_tag="KR257_003326"
     CDS             9487..12189
                     /locus_tag="KR257_003326"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728915.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="EAL domain-containing protein"
                     /protein_id="HBH0031992.1"
                     /translation="MKNVSKKFFVCTIIVLITFLCFSKFAIYVFDKQEKKETKVVENM
                     LNVYKNNIILNLTEKFNYSKDLTSVLVSNNYSIDKLKPIADEILKNNSCIYISVVEKY
                     NVAAFFSNSVKKDIINTPIQELNYSYSLANSIKGLVVEGPSKDQFSNGDVFLITNPIY
                     KNGEYWGEITVALDAKKVVDSFNLNKLKESGFEYELWRVHLDNGSKSTIEISTKDFNF
                     SKSHEIKFKLPTVWTLSIVYKNGWNNKNIDFIVFVILLIISILIGVMTFIYIEKKSIS
                     KELNQQSLKNLETGILNREGFLIKLQEHLNRKNNEIVLLYICITNYSKFAPVMSFEKR
                     QDYLTHIVKNLDNYIKSSHFIARISEEGFVLALEENCDKNELLNIEKGISLELLRKIK
                     VENKQVFLTIGYGSSRCVDDRKDAESLLLSAIEDYERRFPAMSPIHDFTKKCEDMLDE
                     KKQIVFGEYPDLEINKLSKVIYKYYKKVQRIMYKDYNIDIGNRRGYMRDVEVLIDYNS
                     ERMLYLFLIDICKFGKFNELFSIEIGDVILKEVSNKLKTIFSNYLYRINGDVFLGISI
                     DKESYLDTLHKVNEVFNSSLSVEDVLFDVKCNIGICQYPYHGENPYDLLEKVQIALEY
                     AKKDVKSNVKVYDKELTEEIYHENNIIKDLKKGLEEQTLEVWYQPIFNVSKNCYIKAE
                     ALIRLRNKEGGYYSAYEVITYAEKHGLIKDVGLYVLKKACDVTTKIKDKNIDFEQMQL
                     NLSAQQIVHKQCANDILSCIENCGLDKKYISVEVTEKVLMETFEIVNVTLDKLKKEGI
                     SIALDEFGSGFSSINYLANLPIENLKIDKELVEQITYSKKQFELLKTIVQITKINGMD
                     IVAEGVETKETLDLVVTSGVNLIQGHYFSEPLSEDKFIELMIEE"
BASE COUNT         5101 a         1121 c         2190 g         4193 t
ORIGIN      
        1 gaggtagata ttaaagtttt aattttaatt ttattaacct tgtttagtat aaatgtattt
       61 atttcatatc ttaaaattaa gttgtatgag gataaaatta atttaggatt gataaataat
      121 tcagataagt ttataaatat tactaaagat gagaacttcc taaaacatgt tcaaaattat
      181 attatcagta atgaaaaaga aaactgtgta atggcttgtt ttgatttatg tagactcaaa
      241 cttataaatg atatatatgg ttatgagcta ggggatgaag tgttaaataa tattttaagt
      301 aacttaaaaa attattttgg aaaagaagct atttatggaa agttaaaaag tgatgttttt
      361 gtattaataa taaagcttga aaatagggaa cagaagattc cttatttagt aaatcttatt
      421 aagaataaaa ttgtgatact aagtcagatt gacagtttta aaatggatat aaatattgag
      481 gcttctattg gaatttataa atttaacaat aatgaaattg atataaaaaa agctatagat
      541 aatgctgata tggcaaggct taaatcaaaa ggactaaagc acatagagta tgtagaattt
      601 gataatgcta tggaagaaga aatacaatca attatgaaaa tagagagaga tttattcttg
      661 gctattaaaa ataaagagtt tgtaattcac tatcaaccta aagttgattc aagtacaggt
      721 aacattatag gttcagaggc attgataaga tggttgcacc catcattagg catggttgga
      781 ccaaataagt ttatacctat agctgaaaaa aatggtctga taaacaatat tggtagatgg
      841 ctaattcaag aagtttttat taccattaac aagtggattt cagaaggtat aaatgtctta
      901 ccagtctcaa taaatctttc tagagtagaa ctatataaaa atgatttagt tgattttttt
      961 aaactgatgt ttaatacata taatattcca aaagaactta tagaattaga aattacagaa
     1021 acgacagcac taagagatgt aaaatttata agtgaaaggc tttatgagat taaatcttta
     1081 ggtatgaata tatcattaga tgattttgga gtaggtaatt caaattttat caaccttaag
     1141 gggataccac tagatattat aaaaattgat aggtcactta tattggatat agttacaaat
     1201 acaaaaacaa agtttatggt gaaagcaatt gttaaccttt cacatgattt aaacgtaact
     1261 gttatatgtg aaggggtaga ggatatgcat caggtcaaag tcttaagtga actgggatgt
     1321 aatttcatac aaggttatgt attttttaaa cctttggatg agatgaatta taaaaaactt
     1381 cttactgacg gaagttatat aaatctgaaa gatactcttt tagataaatg catgacagtt
     1441 gaggaggagt aaggatgatt tcagaagatg tagattattc aataagaatc ataagagcta
     1501 tatttaataa tggagaagat aaaccaatag atgctaaaat gatattaaaa agtgaagata
     1561 taccaatact aacactatac agactgctta gaaagctttg tgcaaacaat attcttactt
     1621 ttaacaaaga agatggcaag acatacatgt taaatgtgtc attggataca ataagtctaa
     1681 gaactattgt agaagtaatt gatggaaaaa tatatataaa taaatgtacg agatatgtat
     1741 ctaattgcag taattgctta aaaggttgta aagtaaatcg tgaattgcta gaaatagaaa
     1801 aagaaattta taaactttta tcgagaaaat ctataagaca aatactagaa taaaaaattt
     1861 tcagctatga taataattgg aggttttcgg ttatggatga tatatctcaa gataattttc
     1921 tactgtctaa agagtatgag aatagcttag atgtagatac taaaaaagca agtggaatat
     1981 attatactcc taaaataatt gtagattata ttgtgaaaaa aactttaaaa aatcacgata
     2041 taattaaaaa tccatatcca cgaatacttg atatttcctg tgggtgtgga aattttcttt
     2101 tagaagtata tgatatttta tatgacttat ttgaggaaaa tatatatgaa ttgaaaaaga
     2161 agtatgatga aaattattgg actgttgata acatacaccg tcatatatta aactattgta
     2221 tatatggtgc tgatattgat gaaaaagcta taagtatatt aaaagatagc ttaacaaata
     2281 aaaaggtagt aaatgattta gatgaatctg atataaagat taatctattt tgttgtgata
     2341 gtcttaaaaa gaaatggcga tataagtttg attacatagt gggtaatcca ccctatattg
     2401 gtcataaaaa acttgaaaag aaatataaaa aatttctcct agaaaaatat agtgaagttt
     2461 ataaggataa agctgactta tatttttgtt tttataaaaa gattatagat attttaaagc
     2521 aaggagggat tggcagtgtt ataactccaa gatatttttt agaaagtcta tcaggtaaag
     2581 atttaagaga atatattaaa tcaaatgtca atgttcaaga aatagtggat tttttaggtg
     2641 caaatatatt taaaaatata ggggtatcta gttgtattct aacttttgat aagaaaaaaa
     2701 caaaagagac atatatagat gtatttaaaa tcaaaaatga ggatatatgt ataaataaat
     2761 ttgaaacatt ggaagaactt ctaaagagta gcaaatttga acattttaat ataaatcaga
     2821 gattgctatc tgacgaatgg atacttgtaa ataaagatga tgaaactttt tataataaga
     2881 tacaagaaaa atgtaaatat agcttggaag atatagcaat aagttttcaa ggaataatta
     2941 cagggtgtga taaagcgttt attttaagta aagatgatgt aaagttgaac cttgtagatg
     3001 ataaattttt aaaatgttgg ataaaaagta agaatataaa taaatatata gtagataaaa
     3061 gtgaatatag gctaatatac tcaaatgata tagataatga gaatacaaat aaaaggatac
     3121 tagatgaaat tatagggcta tataaaacaa aattagaaaa cagaagagaa tgtaaaagtg
     3181 gaataaggaa atggtatgaa cttcaatggg gtagagaaaa gcttttcttt gaaagaaaaa
     3241 agataatgta tccttataaa tcaaatgaaa atagatttgc tatagattat gataataatt
     3301 tttcaagtgc agacgtatat tcttttttta taaaagaaga gtatttagat aaattttcat
     3361 atgaatatct agttggaatt ttaaattcca gtgtttatga taaatacttt aaaataactg
     3421 ctaaaaaaat gagtaaaaat atatatgatt actatcctaa taaggttatg aagataagga
     3481 tttttaggga taataattat gaagagatag agaatttatc aaagcaaata atatcaattt
     3541 tattaaataa gtctatagat aaaggaaaag tagaaaaatt gcagataaaa atggataact
     3601 tgataatgga ttctttaggt atataagcag ttgtaagtat taaaaaatta taatctttta
     3661 attgtttatt taaatttaga aataaaaagt tagccatata aaaaatatta aaaatatata
     3721 cttttcaata tttttttgat aaaataagaa tgaatttgtg caattttatt tttctccaat
     3781 aactaaaaat agttttttga attaatattt gcttaagaat aaaaatcaga aacgtttttg
     3841 atatagtagg tgataatatg aaaggattag ttttagaagg tggaggaaca aaaggagcct
     3901 accaaatagg tgcatataaa gctttaagag agcttggtat agagtttcaa ggagtaactg
     3961 gcacatcaat tggtgcttta aatggagcat atataattca aaatgatatt gaagtaatgg
     4021 aagatatttg gttaaattat gactatactc attttatgaa tattgataga gaaacctatg
     4081 agaggtttaa aaatgtagat ttcactacta aaaatctcaa tgcagtgttt gagcttataa
     4141 ataaagctag aaaaaatgaa ggtatagata taagcccatt aagacaatta atggagacaa
     4201 cattaaatga agacataata aggaaatcaa aaaaagactt tggacttgtt acggtctggt
     4261 gggataaaaa aattaatcca tatccattgt atatcgaaga tatacctaaa ggaagattga
     4321 ttgattattt aattgctagt tccagtttgc ctatttttca aacgaacatg atggatgata
     4381 agttgtatct tgatggaatg ttttgtgata acatgccaat aggactcttg gaagacaaag
     4441 gttatgaaga tgttgttgta attaggttga ttgatgattt tattgggaaa atgaatctaa
     4501 atcgacatca aaatataaat ataaaaacta taataccatc agaatatcta ggaggttctc
     4561 ttaataaaga tagagataat gtagaaaaaa acatccgact aggttactta gatactatga
     4621 aagcatatga aagatgcact ggaattaagt attattttga tgtagagtat aaatataatg
     4681 aagaatattg ttttgataaa tttagaagta tgagcaatga aacaatacaa tatatctgta
     4741 atttattgaa tataaaaaga gatgcttcac ttagaactgt tatggaaagt gtaataccaa
     4801 agcttggtga ggtgcttgga ttgccaaagg atttttcata taaagatttg ttttactgta
     4861 tatatgaaaa gaaacttgaa gaaaataata taaacaggat aaaattatat gattttaaca
     4921 aggttataga tgttgtaaat acaaatattg attctaatag aaatttagct tctaattttg
     4981 aagttagacc taaaattagt attaaaaaga acaaaaacac aaaattattg acaaattgta
     5041 ttataaaaga cataaaaaat caaagttaaa taaaaaacaa aaaaaaattt gtaattatac
     5101 tcgaaaaaag tgtatattag tagtataata tttttgtagc actagtggga acaaaaaatg
     5161 accataggac aaaaaagtac cacttagtac cattaaagta aaaaacagga aaacaatttt
     5221 aaaaaatata aaatgtaaag tttataggag gatttaaaaa aatggaaaaa gtagttagta
     5281 tcaaaaatgc aagtggatta catgctagac cagcaggaat gtttgttaag aaggcagctg
     5341 aatttaaatc aacagtagag gttgtagcaa aagacaaaac tgtaaatgca aaatcaataa
     5401 tgggaataat gagtttaggt ttagctcaag gagaagaatt aaagttagtt gtaaatggag
     5461 aagatgaaga agtagcttta gctgcaatgg ttgaattagt tgaaagtgga tttggagaat
     5521 agatataata attttttaaa aatttgatat ttagaatcta atattactta aagtaaagta
     5581 acagagaagt attaaacata tacagaccaa catttgtaga tatttaattt ctttgttact
     5641 ttcatgttta tttaatcaga agattaagac tattgttaat tgggtataaa aatataaata
     5701 ttttagaaaa tgaaataaga tatttttaat cataaattca gagtaaaaat acagtaacaa
     5761 atagtttata aaattttata aaaaattata agtaaataaa actataaaaa tgtaaattat
     5821 ttatataaat ttataaagtt tatgtgctag atgatatttt ttaggaggta gagttatggc
     5881 ttacaaagga ataggtgctt ctcctggtgt tgctttaggg aaagcgttag tagttgaaca
     5941 tagtgaatta gtaattgaaa aaaaatctat agataatgtt gaagctgaaa ttgctaaatt
     6001 agaagatgca gttgcagttt ctaaagaaga attagtaaaa gttaaggaaa aggcttctga
     6061 agaattagga gcagaggaag cagaaatatt tgaagcacat ttattagttt tagaagaccc
     6121 agagttaatt ggttctgcaa tagataaaat taaaactgaa agtgtaaatg cagagtatgc
     6181 tttaaatgaa ataaaagaga tgtttgttag catgtttgag tctatggaca atgagtacat
     6241 gaaagaaaga gcggcagata taaaagatgt tacaaataga atacttagac atatattagg
     6301 aattaaagtt gttgatttat ctgctttaag cgaagaagtt gtattaatag cacatgattt
     6361 aactccatca gacacagcaa ctatgaataa aaaaatggtt ttaggatttt taactgatat
     6421 aggtggaaga acttctcata ctgctatcat gtctagaact ttagaaatag ctgcaatcgt
     6481 tggattaaat gatataactt caaaagttaa ggatggagat tttgtggttt tcaatggaga
     6541 cacaggtgaa gtaatcgtga atcctgatga agagactata aataaatata ctgaattaaa
     6601 agctaagtat gaagatgaga gaaaagcatt acagctatta aaaggaaaac catctgtaac
     6661 tttagacgga aaacatgtgg aattagctgg taatatagga acacctaacg atatagaagg
     6721 tctaataaag aatgatgctg aaggtgttgg tctttataga acagaatttt tatacatgga
     6781 tagagattct ttcccaacag aagaaataca atatgaagca tacaaagctg tattagaagg
     6841 aatggatgga aagcctatag ttataagaac attggatata ggtggagata aagaattaag
     6901 ttatttaagt atggaacctg aaatgaatcc attcttaggt tacagagcaa taagactttg
     6961 cctagataga aaagatatat ttaagactca attaagagct ttatatagag ctagtgttca
     7021 tggaagatta agaatcatgt tcccaatgat ttcatcttta gaagagttgt tacaagctaa
     7081 agaagttgta aaagaagttt tagcagaact tgattctgaa ggtgtggctt atgctaaaga
     7141 tgtagaaatt ggtatgatga tagaagttcc atctgctgct gtaatatctg atgtattggc
     7201 taaacacgta gatttcttct ctataggaac taatgattta attcaataca cttgtgcagt
     7261 tgatagaatg aatcaaaaga taagctatct ttacaatcaa tttaatccag ctgttttaag
     7321 acttataaag actgttatag acaatgcaca taaagaaggc aaatgggcag gtatgtgtgg
     7381 agaatctgct ggagaccaaa aaatgatacc aatactttta ggtatgggat tagacgagtt
     7441 ctctatgtct ccaatatcaa tacttcctgc tagaaagtta ataacttcag ttaaagagtc
     7501 agatatgaaa aaattagctg atgatgtact taatatgggt actgctgaag aaataaaaag
     7561 ctatatagaa aagactttta atatataatt aatgttatat agttactaaa attcattttt
     7621 ctaaataaca aaattatatt ttacgaataa aaaaactata gtatatcata tatactatag
     7681 tttttttgtt atataaatta cgtatcaaaa tttgtaaaat gaatagatat aattactaaa
     7741 tatgtgatag tattggctat aataggatat aaaaaataat attgtaaaaa aaagtttata
     7801 tttagtaatg aaaatttaac gttttacttg aaattatgtg ttttgtaatg tattattaag
     7861 gctctaatag gaacattttc atcaattttt ctatagtggg ggtaggaatt atgaggtaca
     7921 aaaaaagaaa tatagataag tcaagtgaac tttcatttca atctctagca aaatatttta
     7981 taactttcta tatagtaatt atattaatta ttctttctat gttttgtata aatacaatat
     8041 gggttatgaa aaaagataat caagatttat tatctacaac atcaaatcgt attgaagata
     8101 gggtaggaga aacaattaag ctattgaact ctttgagtaa agataattac ataatagata
     8161 atagtgtgaa tggcatagat aaaagtaaag aactttcaat gtatagtgat gaatttgggt
     8221 atatgatgat atgttttgtt gataagaata taattgtgtg ggatgaagaa ggtggtaata
     8281 ttagtctagc tggtcgtgat tatatgcaga aactttttgc aacaaaaaaa tatcaagtta
     8341 cagatagttt tgcagcaggg gctgatggaa aaactttaaa ctacactatt gcatcaccta
     8401 taataaagaa tggaaatgta gatggttgtg tatttgcagc aatttacttt gatgagataa
     8461 aggatatact caaacaagga aaaggtcaac agcaacagaa tttcatatta tttggaagtg
     8521 aaaatcaaat aatgaattta acaagtgatg aaactgcata tggagagaag tatatgaagt
     8581 tatcgcagaa aacaaaatat cttggaacca atgcaaaaaa agtagaaaag gatatgttta
     8641 ataataaatc aggtgattat tgggcttttg aaaatggaaa attatacttt atgtcctata
     8701 aaccaattaa gaacacaaat tggagtttat tttgtaaagt taatttctta gatatttttg
     8761 cattaaattt aattcctatg ggagctattc tatctgttat aactttagta tttattattt
     8821 tgatttgtat ggagaaaagc ttcatgaaaa aacgaatgga agttattgat atgcttttag
     8881 gttctgttca agaattagaa aaacgtatat atcaaacaga aagacctagt gaagtagact
     8941 ttaaagaaat tattcagctc acaagtaaag gtctgactga tggattaact ggtgttgtaa
     9001 cacgtactgt attttttgac caaatttata atcgtgttga aatggaggaa aatgataaat
     9061 tatctgtaat ttcatttgtt gatttagatg atttgaaatg tattaacgac ttatatggac
     9121 atgaaattgg ggatatggtt ttgaaaaatg ttggatatgt acttcgtgaa tatgagataa
     9181 aatataatgg tttaattggg cgctatggtg gagatgaatt tgttatgttg ttatctggtt
     9241 ttacatcgag agaagaggtg gaggatttat tggatgagat tgctattcgc ttacatactg
     9301 aagtactaac agatgatggt atcattcaaa ctcattgtag tgttggagct gtagtatgta
     9361 gtgtaaaaga caataaagat atagataatt tattaaaaca ggctgatgaa gctttatact
     9421 atgttaaacg taatggaaaa ggtaattatc atttagttta atgtatgtgg aaggagttta
     9481 tatcatatga aaaatgtatc taaaaaattt tttgtatgta ctattattgt attaataaca
     9541 tttttatgtt ttagtaaatt tgctatttat gtttttgaca aacaagaaaa gaaagaaaca
     9601 aaagtagtag aaaacatgtt aaatgtctac aagaataaca ttattttaaa tctgactgaa
     9661 aaatttaatt atagcaaaga cttgacatca gttttagttt caaacaatta ttctatagat
     9721 aaattaaaac ctattgcaga tgaaattctt aaaaacaatt cttgcatata tatttcagtt
     9781 gtagaaaaat ataatgtagc tgcatttttt tctaattctg tcaaaaaaga tattatcaat
     9841 actccaatac aggaactgaa ttattcttat tcattagcaa attctatcaa aggattagtc
     9901 gtagaaggtc cttctaaaga ccagttttca aatggagatg tgtttttaat tactaatcct
     9961 atttataaaa atggagagta ctggggagaa attacagtag ctttagatgc caaaaaagtt
    10021 gtagattctt ttaacttaaa taaattaaaa gaatctggat ttgagtatga actttggcgt
    10081 gtacacctag ataatggttc aaaatctaca atagaaattt ctactaaaga ttttaatttt
    10141 tccaaatcac atgaaattaa gtttaaactt ccgactgttt ggactcttag cattgtgtac
    10201 aaaaatggat ggaataataa gaatatagat tttattgtat ttgttatatt gttaattatt
    10261 tctatattaa taggtgtgat gacatttatt tacattgaaa agaagtcgat tagtaaggaa
    10321 ttaaatcaac agagtcttaa aaatttagaa actggtattt tgaatagaga aggtttttta
    10381 attaagttgc aagagcatct gaatagaaaa aataatgaaa tagtgttgct gtatatatgt
    10441 attactaatt atagtaaatt tgctccagtt atgagctttg aaaaaagaca agattatctt
    10501 acacatatag taaaaaatct agataattac ataaaaagtt ctcattttat tgctcgtata
    10561 agtgaggaag gttttgttct agctttagaa gaaaattgtg ataaaaatga attgcttaac
    10621 attgaaaaag ggatttcctt agagctttta cgaaaaatta aagtagaaaa taaacaagta
    10681 tttttaacga ttggttatgg ctcatctagg tgtgttgatg atagaaaaga tgcagaatct
    10741 ctgttacttt cagctattga agattatgag agaagatttc cagcaatgtc tcctattcat
    10801 gattttacta aaaagtgtga agatatgctt gatgaaaaga aacagattgt atttggtgaa
    10861 tatccagatt tagaaataaa caagttgtct aaagtaatat acaaatatta taaaaaagta
    10921 cagcgtatta tgtataaaga ttataatatt gatattggaa ataggcgagg gtatatgcgt
    10981 gatgtcgaag tattaattga ttataattct gagagaatgt tatacttatt tttaatagac
    11041 atatgcaagt ttggaaaatt taatgaactg ttttctattg aaataggaga tgttatttta
    11101 aaagaagtta gtaacaaatt aaaaacaatt ttttctaatt atctatatcg tattaatgga
    11161 gatgtatttt taggcatttc aatagataaa gaatcttact tagatacttt acataaggtt
    11221 aatgaagtat ttaatagttc tttaagtgta gaagatgtac tttttgatgt aaaatgtaat
    11281 attggtattt gtcaatatcc atatcatggt gaaaatccat atgaccttct ggaaaaggta
    11341 caaattgcat tggagtatgc aaaaaaggat gtcaaaagta atgttaaagt ttatgataag
    11401 gaattgacag aagagattta ccatgaaaat aatattatta aggatttaaa aaaaggtctg
    11461 gaagaacaaa cactagaagt ttggtatcag ccaattttta atgttagtaa aaactgttat
    11521 ataaaagctg aggcactaat tagattgaga aataaagagg gcggttatta ttctgcctat
    11581 gaagttatta cttatgcaga aaagcatgga cttattaagg atgtaggtct atatgtacta
    11641 aaaaaggctt gtgatgtaac tacaaaaata aaagataaaa atatagactt tgaacaaatg
    11701 caattaaatt tatctgctca gcagattgta cataagcagt gtgcaaatga catattatca
    11761 tgtattgaga attgtggtct agataaaaag tatatttctg ttgaagttac agaaaaagta
    11821 cttatggaaa cttttgaaat tgtaaatgtt actcttgata aactaaaaaa agaaggcatt
    11881 agcatagctt tagatgagtt tggttctgga tttagtagta taaattatct ggcaaattta
    11941 cctattgaaa atttaaaaat agataaggaa ttagtagaac aaattaccta ttctaaaaaa
    12001 caatttgaat tattaaaaac tatagttcaa attactaaga ttaatggcat ggatattgta
    12061 gcagaaggtg ttgaaacaaa agaaactctg gatttagttg taacttcagg tgtgaatttg
    12121 attcaaggtc attatttttc agaaccttta agtgaagata aatttattga acttatgatt
    12181 gaagaataaa ggttaataaa ataaagattt aaggtattga aaaataatta aaagtattta
    12241 ataatagaat tagggaagaa taagtttata agtaaaaaca attgattagt agttaataaa
    12301 ataaatgtga tatccaaata aatcctaaat ctaatttgag ttttaatata gatagtctaa
    12361 agtttgatta ttaaagattt aattgtaagt tgttacagtt gatgatattg attagagatt
    12421 aaagtttaga gtagaaagtt accttaaatt taaaaatgca agataaccca atctaaaaat
    12481 tataatcact cgataggttt aaggatttat ttgtttatta taaataggag ggtgtctcaa
    12541 aatgaacttt ttagtttatg aggcactctc ttttatatag aattaaatat attttattat
    12601 ttcaa
//
LOCUS       DAEPID010000101        12471 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.101, whole genome shotgun sequence.
ACCESSION   DAEPID010000101 DAEPID010000000
VERSION     DAEPID010000101.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 12471)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 12471)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..12471
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.101"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            complement(217..2328)
                     /locus_tag="KR257_003327"
     CDS             complement(217..2328)
                     /locus_tag="KR257_003327"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895629.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBH0031993.1"
                     /translation="MTINKLYSKLRAYNWKNYTTLFFCIILSVVLVTSYALIYFSPTI
                     QNILPTGGDSRKQATMIFSVAILGCAVFTTYASSLFLKFKSKEIGIFMALGTDKKKLK
                     KLLFSEILLISIVCCFLGLILSIPVSFGIWKIFQLVIIDTREMTYHFGTQGFIYGFIF
                     SVFVTLCIFILSVKFINRTNIIDILNDQRISEPIQDVKDWYGILGIIFIILGIFLGYL
                     VPSLTINKLNYKLPSIWSFTYLLSLIGIYMIMTYIVVHAKRGKHPEKYYKNIISTSMM
                     RFMGRQTVKNMCVISFLIAGALFAVFYVPNMVTGIYDTLKNNPIDYTFTYNQRDKQVS
                     KKDIEQLADKHNIKIQNYMEIPSIELIVDGVESIYHKDGTIEKVYMKKSSYDMFFNSK
                     DFSKLIGKPITIKNGEYLAVVNKGNENQDYKYTKFISSPVTEKEIPFRYAGKIIFNGS
                     FFQNRSMNAYVLNDEDYKSFTKDLSIKNYNNSILFNVDKDTYAFANDLKKEIIKRTSK
                     EMGMFSGYDEYVKKRYESTGRKYFMDEEYPSGEGHLKLDPNNNQLYLNWKYYPNFKIL
                     QSQDMIKNMAVFLMLFIYVAIICFTAVGIIAYTRGVTIAINHKQVFMDLNRLGANNDY
                     IKFCIRNQLKKVFSYPLIAGSFLIYLFNFMIMLNNDGRIVNSEVNALLINLGFIGICG
                     VYMYLIYLLTYKKFKKIIGIL"
     gene            complement(2318..3070)
                     /locus_tag="KR257_003328"
     CDS             complement(2318..3070)
                     /locus_tag="KR257_003328"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728886.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBH0031994.1"
                     /translation="MLKVNQLCKSYKTGSKTYPVLKNISFEINKGEFVAIMGSSGSGK
                     TTLLNCISCFIPIDNGEIILGNNNIRNLKEKELSEVRNQQLGFVFQDFMLFDGLSVFE
                     NICVPQIIKGSQVLQMENRAINLCELFGIEHIRKKYPAEISGGEKQRTAVARALMNNP
                     DLILADEPTGNLDSKSCRTVIESFLKAKQELDATILMVTHDSFAASFCDRVIVLKDGI
                     IYKEVVKSNSRHKFLDELLEVLKEMGGAQDDN"
     gene            complement(4336..4512)
                     /locus_tag="KR257_003329"
     CDS             complement(4336..4512)
                     /locus_tag="KR257_003329"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418084.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0031995.1"
                     /translation="MFFTFIGVISAILLLCTIICGLWIKLNNRNNDSNSHFTFSILSI
                     AFSLLIVVAFLVRN"
     gene            complement(4616..5224)
                     /locus_tag="KR257_003330"
     CDS             complement(4616..5224)
                     /locus_tag="KR257_003330"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429516.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="HBH0031996.1"
                     /translation="MGKLLRGKIMKADSTKEQLINATIQLLSSHRDVSSITAREIVAK
                     ANVNLAMINYYFKSKEELINISIKKFLKRHMDEYKATHDTKNLAPKQQLREILIAFFD
                     FIGEHSQFIKISVPYILIQEEIVYPFEILPLIKAHYENQNNKKTEAEYRTIAYQITSF
                     IQLLFLRSNAFFKYSGIDILNIEQRNGLIDFQLDLLLVDITK"
     gene            complement(5323..6147)
                     /locus_tag="KR257_003331"
     CDS             complement(5323..6147)
                     /locus_tag="KR257_003331"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437657.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MerR family transcriptional regulator"
                     /protein_id="HBH0031997.1"
                     /translation="MFKIGEVSKLTQISIRMLRYYDELGILKPAEIDKYTGHRLYSVE
                     QISILQRIVLLRDSKFSVAEIANIVHNWNDEFVIKELNRKKNEIQKEINQEQQRINKI
                     DKFIEAINCDKDEIHYNVVFKKIPSYKIISLREIIPDYQSEGILWEKLSKFIKEEHIE
                     VSRQSNNNIAFYHDEEVKDNGVDIEVGMVVKKIGKNKSGFIYRETEEIDMMACTMVYG
                     PYENIAGAYESFCYWLDKNSDYQISGINRQIGHKGEHNEINPENYLTEIQIPLIKV"
     gene            complement(6325..7218)
                     /locus_tag="KR257_003332"
     CDS             complement(6325..7218)
                     /locus_tag="KR257_003332"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902037.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CPBP family intramembrane metalloprotease"
                     /protein_id="HBH0031998.1"
                     /translation="MQLYNTPFNTNKHLIYFFTFTLVLNWIFSLTPALLGITNTILGE
                     IIFYLAYTSPAIVGLFFISTIYPQSAKQDFIYRYLSFKEIRIKWILLTILFFALTFIT
                     SLIIGNYFNVKTSDIDWIHIAVFRPSKIAYMLLASFILSILSQEAGWRGYAIDKLLVR
                     FGFIGSSIILGLVCGIWYLGSYFTPNQIPYNLAQYSLFDAFLFIPNIVLLNFIINFVY
                     INTSRSILSAGLVHMMYYFFNIQLLLHYPIKLCVIAQYVQIIFGLIFLVYMISSNKFK
                     QKVNSEIEQIKSDDFEFELDW"
     gene            complement(7475..7912)
                     /locus_tag="KR257_003333"
     CDS             complement(7475..7912)
                     /locus_tag="KR257_003333"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895641.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LytTR family transcriptional regulator
                     DNA-binding domain-containing protein"
                     /protein_id="HBH0031999.1"
                     /translation="MKIHVEQGINCDDIEITIKCSALDNNIEKIISLLSTPLLDIKGK
                     KSGEIYKLNVCDILYFETVGNKTFAYYEDDVFEIDLKIYKLSKLLANTSFSRISKSMI
                     LNMDYIKSIKVISHNRMQATLKNNEKVIINRRYIKNIKEKLNI"
     gene            complement(8169..8318)
                     /locus_tag="KR257_003334"
     CDS             complement(8169..8318)
                     /locus_tag="KR257_003334"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429511.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YvrJ family protein"
                     /protein_id="HBH0032000.1"
                     /translation="MDDSLQLLITNVGFPIALSMYLLVRIEGKLNTLSNSIDTLSKNI
                     LIFKK"
     gene            complement(8331..8561)
                     /locus_tag="KR257_003335"
     CDS             complement(8331..8561)
                     /locus_tag="KR257_003335"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437662.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF2922 domain-containing protein"
                     /protein_id="HBH0032001.1"
                     /translation="MEIKKKLVMSFKNVKDKQVSFSIENPKDDLTEENIKSVMDLIVS
                     KNIFSVGGFDLASVVEAKVVETNTTPYDLVIE"
     gene            complement(9379..9600)
                     /locus_tag="KR257_003336"
     CDS             complement(9379..9600)
                     /locus_tag="KR257_003336"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437342.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1659 domain-containing protein"
                     /protein_id="HBH0032002.1"
                     /translation="MEVVSTKNLSSIKLKLDAGFDDKGKAVVKSKSFANVKAEALNED
                     VYAVAEAIASLQENPIVDILKLDSTSLSK"
     gene            10180..10437
                     /locus_tag="KR257_003337"
     CDS             10180..10437
                     /locus_tag="KR257_003337"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437357.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcriptional regulator"
                     /protein_id="HBH0032003.1"
                     /translation="MKIKVEDIPVQFHAMVEIIGIDKFIEVAKLYGGTNTYIPTYKGL
                     FRYARNRDIVKQFNGVNHNELAIRYNMCVSNIKRILNENNV"
     gene            10906..12144
                     /locus_tag="KR257_003338"
     CDS             10906..12144
                     /locus_tag="KR257_003338"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888414.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="conserved phage C-terminal domain-containing
                     protein"
                     /protein_id="HBH0032004.1"
                     /translation="MNKGFYKLNSVVLNFDIKNDVNKIRFNHYIMRKENIQRLQGTLP
                     NGQFYMTVRRAATDLQLSISTISRLVKEFLDLGIIRLVSKGVKGNRSVYSYVSIEFNG
                     SLFDDSKYMELDCVCNDEFIDNSGIEFDCDSKDNSFNGDINVETVHCINEYLSDDDVE
                     HNYNNFHNKDTIKDKAISNISTIKKYIDESFDKNKSENSNLQQESINFNFNDTCNEID
                     KRTNNSIENNQNKRPMRLSDISLLSDKGMTNKKNYFNHNHGIQKGTKSVTKKKESLNK
                     FNKKNIQQSIINMLNKKSGKNFKIDSPISIKLINERLKEGYVLEDFYKVIEVKVAKWK
                     NTIMEMYIRPETLFSYKFESYVNENISMKSQSNVHPCKEGNSNDSSNYIHSDYTTYDG
                     SVRERKKYENVRYWNPICEI"
BASE COUNT         4650 a         1473 c         1662 g         4686 t
ORIGIN      
        1 taatgatttt cttattaaaa aatctaacaa tctttcttat tataaaatac aaatgctttt
       61 attattataa aaagtaatga ttttattact ttaaaaatct aataaccttt cttattataa
      121 aacaccaatg attttattac tttaaaaatc taataacctt ttttattata aaacaccaat
      181 gattttatta ctttaaaaat ctaataacct tttttattat aaaataccaa taattttttt
      241 gaatttctta taagttaata gatatataag gtacatataa accccacaaa tccctataaa
      301 acctaagttt atcaaaagag cattgacctc actattgacg attctaccat cattatttaa
      361 cataatcata aaattaaaca gataaattaa aaaacttcct gcaataagag ggtatgaaaa
      421 tactttcttt aattgatttc taatacagaa ctttatataa tcattgtttg ctcctaatcg
      481 atttaaatcc ataaagacct gcttgtgatt tatagctata gtaacacccc ttgtatatgc
      541 aatgattcct actgctgtaa aacatatgat tgccacatat atgaataaca ttaagaagac
      601 tgccatgttt tttatcatat cttggctttg taaaatttta aagttaggat agtatttcca
      661 attaagatac aactgattgt tgtttgggtc tagttttaaa tgaccttcac cacttggata
      721 ttcttcatcc ataaaatatt ttcttccagt tgattcataa cgttttttta cgtattcatc
      781 ataaccactg aacatgccca tttccttaga tgttcttttt ataatttctt tctttaagtc
      841 attggcaaaa gcataggtat ctttatctac attaaatagt atagaattat tgtaattttt
      901 tatggataaa tctttagtaa atgatttata atcctcatca ttaaggacat aggcgttcat
      961 acttctattt tgaaaaaaag aaccattaaa tattattttt ccagcatatc taaaggggat
     1021 ttctttttct gtgactgggc ttgatataaa tttggtatat ttataatctt gattttcatt
     1081 tcctttattt acaacagcaa gatattcacc attttttata gttattggtt tgccaattag
     1141 cttggaaaaa tctttagaat taaagaacat atcataggag ctttttttca tatatacctt
     1201 ttcgatagtt ccatctttat gatatattga ttctacacca tcaacaatta attctataga
     1261 aggaatttcc atatagtttt gaatttttat attgtgttta tctgctaatt gttcaatatc
     1321 tttttttgat acctgtttat ctctttgatt gtaggtaaaa gtataatcta tagggttatt
     1381 tttaagagta tcatagatac ctgtaaccat attaggaaca tagaatacag caaataatgc
     1441 tcctgcaatc aaaaatgaaa taacacacat gttttttact gtttgtcttc ccataaatct
     1501 catcatgcta gttgatatga tgtttttata gtatttctct ggatgttttc ctcttttagc
     1561 atgtacaact atgtatgtca taatcatata tattccaata agagagagta gataagtaaa
     1621 gctccatata gatggtagtt tataatttaa tttgtttata gttagtgaag gtacgagata
     1681 tcctagaaaa ataccgagta taataaaaat tatacctaat ataccatacc agtcctttac
     1741 atcctgtatt ggttcagata ttctctggtc atttaatata tcaattatat ttgtacgatt
     1801 aataaatttt acagaaagta taaatatgca taatgtcaca aatacactaa atataaatcc
     1861 atatatgaat ccttgagttc caaaatgata tgtcatttct ctggtatcaa taatcactaa
     1921 ttgaaatatt ttccatatac caaaagatac aggaatactt aatataagac ctaaaaaaca
     1981 gcatactatt gaaattaaca atatctctga aaatagaagt ttttttaatt tcttcttatc
     2041 tgttcctaga gccatgaaaa taccaatttc cttgctttta aattttaaaa agagggaaga
     2101 agcgtatgta gtaaagacag cgcatcctaa tatagcaact gagaatatca ttgtagcctg
     2161 ttttctgcta tctccaccag ttggaagtat gttttgtatt gttgggctaa aataaattag
     2221 agcatatgaa gttactaata ccacagaaag tattatacaa aagaataaag ttgtatagtt
     2281 cttccaatta taggctcgaa gtttactgta taatttatta attgtcatct tgagcgcctc
     2341 ccatttcttt taaaacttct agtaattcat ctaggaattt atgtcttgaa tttgatttta
     2401 caacttcttt ataaattatt ccatctttaa gcacaataac tcggtcacag aagcttgctg
     2461 caaagctatc gtgtgtaacc atgagtatag tagcatctaa ttcttgcttt gcttttaaaa
     2521 atgattcaat gactgtacga caagacttac tatcaaggtt accagttggt tcatctgcta
     2581 atattaaatc tgggttgttc atgagtgctc ttgctactgc tgtacgctgt ttttctccac
     2641 cagatatttc ggcagggtat ttttttctga tatgttcaat accaaatagc tcacatagat
     2701 taattgcacg gttttccatt tgtaagactt gactaccttt gataatttgt ggaacacata
     2761 tattttcaaa gacactaaga ccatcaaata gcatgaagtc ttggaataca aatcctagtt
     2821 gttgatttct aacttctgaa agttcctttt cttttaaatt tcttatatta ttatttccaa
     2881 gaattatttc cccattatca attgggataa aacatgaaat acaatttaaa agagtagttt
     2941 ttccacttcc tgatgaaccc atgattgcga caaattctcc tttgttgatt tcaaaagaaa
     3001 tattttttaa tacaggatat gttttactgc ctgttttata tgatttacat aattggttta
     3061 ctttaagcat atatatcatc ctcactttca tttatcttgt aagtcaatga tagcatttga
     3121 aaggggagga gggatatgag ctatattgta atagttggat gtttttttgt aatgtttgaa
     3181 aatatattgt ttggatagtg tgagaggtta ttattatagt taaattgatt atattattgg
     3241 aggatttaga gggttatttt taggtattaa ttgttgtgct aaagtaatat gatgtggaac
     3301 attgaaggtg tagttagaaa agaagtatat agtaaaagta aaaaggttat agaataacga
     3361 atgttgtatt gaaaaaaatg atgtaaataa tgtatagtag ggttaaaaag aaaaaaagaa
     3421 ttatagagca gtaagattat ttaatagaat gtattgtaaa taatttgaaa ggatttaggg
     3481 gctattaaca caatgtaatt gagaaaatat attggagttt tggaaataaa taggttgtta
     3541 gaaacaattg aaatgtataa taaaaaggtt aaaaagtatt attagtatag gtatgataga
     3601 taattttaga aagtggaagt attttagact atgctgaaaa gtgattgata tgattttgag
     3661 atattaaaat attactatat tatagtaaag aagttaaaat aataaaatgt tgtaataata
     3721 aaggtttgta gtataataaa gaactgtaat aaataagact ttgcaatgta atagaaatgc
     3781 tgtaataata aaagtctgta gtataataaa gaactgtaat aaataagact ttgcaatgta
     3841 atagaaatgc tgtaataata aaggtctgta gtatagcaaa gaactgtaat aaataagaga
     3901 ttgtaataat aaaagtctgt agtgtaataa agaactgtaa taaataagac tttacaatgt
     3961 aatagaaatg ctgtaataat aaaggtctgt agtataataa agaactgtaa taaataagac
     4021 tttacaatat aatagaaatg ttgcaataac aaaacaccat aataaataag agtttgcaat
     4081 ataatagaaa cactgcaata aataagagat ttcaatataa taaaagtctg taatataaca
     4141 aaatcctata ataaataaga ttttacaata taataaaaat cctataataa ataggactct
     4201 gtaatataat aaaatgctgt aacaacaaaa cactataata aataagaccc tgtaatataa
     4261 taaaaatact ataatatagt aaaaatcatg caataataaa aatctataat aataaacctc
     4321 agcataacaa agacattaat ttcttactaa aaaggccacc acaattaaca gtgaaaaagc
     4381 aattgaaagt attgaaaaag taaaatgaga attagagtca ttattacgat tattaagttt
     4441 tatccataaa ccacatataa ttgtacacaa caataaaatt gctgatatta ctcctataaa
     4501 tgtaaaaaac attaaaattc ctccccctta tttaatgcaa gtatttttag tcaatgagaa
     4561 tattttcaaa cgttaccata aaataaaaaa atgtacataa aaaattaata tagtattatt
     4621 ttgtaatatc taccaataat aaatctaatt gaaaatctat taaaccattt ctctgttcaa
     4681 tattaagaat atcaatacca ctatacttga aaaaagcatt agaacgaaga aaaagcaact
     4741 gaataaatga agttatttga tacgcaatag ttctgtattc agcttcagtt tttttgttat
     4801 tctgattttc atagtgagcc ttaattaaag gtagtatctc aaatggataa acaatttctt
     4861 cctgtatcaa tatatagggt acagaaatct ttataaattg actatgttca cctataaaat
     4921 caaaaaatgc aattagtatt tcccttaatt gctgtttagg tgctaaattt ttagtatcat
     4981 gtgtagcctt atattcatcc atatgacgct ttaaaaattt tttaatagaa atattaatta
     5041 actcctcttt agatttaaaa taataattaa tcatagctaa attgacattt gctttagcta
     5101 caatttctct agccgtaatg cttgaaacat ctctatgtga agatagtaac tggattgtgg
     5161 cattaattaa ttgttccttt gttgaatctg ctttcataat ttttcccctt aaaagtttcc
     5221 ccataaaaaa attaaacatg tttaacacac gtttagatac tatcatgaaa attttgggat
     5281 gtcaatgggt gattagtact taagtattta agtactaatc tattagactt ttataagggg
     5341 gatttgaatt tctgtaagat aattttcagg atttatttca ttatgttcac ctttatgtcc
     5401 gatttgtcta tttatacctg atatttgata atcactattt ttatctaacc aataacagaa
     5461 cgattcatat gcaccagcta tattttcata tggaccataa accatagtac atgccatcat
     5521 atcaatttct tctgtctcac gatatataaa tccagatttg ttctttccaa tcttctttac
     5581 aaccattcca acttcaatat ctacaccatt atctttgact tcttcatcat ggtaaaaagc
     5641 tatgttattg ttggattgac gtgatacttc tatatgttct tctttgataa atttagatag
     5701 cttttcccag agtatacctt cagattggta gtctggaatt atctctctaa gtgatatgat
     5761 tttataactt ggaatctttt taaagacaac attgtaatga atttcatctt tatcacagtt
     5821 tatagcttct ataaatttat caattttatt tattctttgt tgttcctgat ttatttcctt
     5881 ttgtatttca ttcttttttc tattcaattc tttaattaca aattcatcat tccaattatg
     5941 tacgatattt gctatttctg caacgctaaa ttttgaatct ctcaataata caattctttg
     6001 tagtattgaa atctgttcaa ctgagtataa tctatgacct gtatatttgt ctatttctgc
     6061 aggttttaaa ataccaagtt catcataata acgcaacata cgaatagaaa tttgtgttag
     6121 ttttgaaacc tctcctattt taaacatgaa aatatgacct ccttttcact tataatcagt
     6181 atatattttg tttttatata cttcaagcgt ttgtggaaat acaattattt tccagatgtt
     6241 gcaataaatt atagagagta aattatattt aagtagtaat cgtatcaaat catagattat
     6301 cttaatttat aattcatatt aaaattacca gtctaactca aattcaaaat catccgactt
     6361 tatctgttca atttcagaat ttaccttctg tttaaattta ttagaagaaa tcatatatac
     6421 aagaaatatt aaaccaaata ttatttgtac atattgagct attacacata atttaatagg
     6481 gtagtgtaga agtaattgaa tgttgaaaaa atagtacatc atatgaacta acccagctga
     6541 taaaatgctt ctacttgtat tgatatatac aaaattaatt ataaagttta aaagtacaat
     6601 gtttggtata aataaaaaag catcaaatag ggagtattgt gccaaattat atggtatttg
     6661 attaggtgta aaatacgacc ctagatacca gattccacaa acaagcccta aaataattga
     6721 agagcctata aatccaaatc taactaataa tttgtcaatg gcatatcctc tccatccagc
     6781 ttcttgacta agtatactca atataaaact tgctaatagc atataagcta ttttagaagg
     6841 tctaaacact gctatgtgta tccaatctat atcagaagtt tttacattaa agtaatttcc
     6901 gattattaac gaagtaataa aagttaaagc aaaaaataat attgttaata gtatccattt
     6961 tattctaatt tctttaaagc ttaggtatct ataaataaaa tcttgttttg cactttgtgg
     7021 atagattgta gaaataaaaa atagacctac aatagctggt gatgtatatg caagataaaa
     7081 aatgatttct ccaagtattg tatttgtaat tccgagcaac gcaggtgtaa gactgaatat
     7141 ccagttcaat actagcgtaa atgtaaagaa atagattaag tgtttgtttg tattaaaggg
     7201 ggtgttatat agttgcattt tttcactatc cttccgtttt ataatgaagt tttaattttt
     7261 attaattgtt tatttatttt tatatgtatt aagttatcgc ttgatgttag ttattgccta
     7321 taataatatc ctatttttta tattttgatt aattattttt acactaaata taattaatta
     7381 gtatttaata ttgaatatat tatattatta ttaattatta aataggtcaa taaatttgca
     7441 attagtgata ttaataaatt actttagatt tttattaaat gtttagcttt tctttaatat
     7501 tttttatata acgacgattt ataataactt tttcgttgtt ttttaaagta gcttgcatgc
     7561 gattatgtga tattactttt atacttttta tgtagtccat atttaaaatc atggatttag
     7621 atattcgtga gaaggatgta ttagctaata attttgataa tttatatatt tttaaatcaa
     7681 tttcaaatac atcatcttca taataagcaa atgttttatt tccaactgtc tcaaagtata
     7741 aaatatcaca gacattgagt ttataaatct ctcctgattt tttacctttt atatcaagta
     7801 acggtgtact caataatgaa attatttttt caatgttatt atctagagca gaacatttta
     7861 tggttatttc aatatcatca caattaatac cttgttcgac atgtattttc attaatcatc
     7921 acctcatttt attactgtca ttagaatagc attatatctt attgagtcca actagatgcg
     7981 ttctaaattt caaattaagc atagtgaaat tcaaaaataa aacagtgaaa ttcaaatttg
     8041 aggtggtaaa attcaaaaaa atactatgga tatttggata aattatccaa atatcctagt
     8101 atttcacata gaatatgtct aattatttta caaatagacc tattttatga cttacatata
     8161 ttgtcaaatt acttcttaaa tatcaaaata tttttggata atgtatcaat actgtttgat
     8221 aaagtattta atttaccctc aattctaacc aataagtaca tggatagagc tataggaaaa
     8281 ccaacattgg ttattaacag ttgtaaacta tcatccataa aattagcccc ctattctata
     8341 actaagtcat aaggagtggt atttgtttcc acaaccttgg cttcaacaac agaagctagg
     8401 tcaaatcctc caaccgaaaa aatattttta gatactatca aatccatgac agattttata
     8461 ttttcttcag ttaaatcatc ctttggattt tctatagaaa aagaaacttg tttatccttt
     8521 acatttttaa agctcatgac taattttttc ttaatttcca tataattacc tccgatataa
     8581 taatttatat tttaattgtt tgcttgttaa tattggtatt ttaattgtca atattaatgt
     8641 tttgcttgtt agtattaata tttcaattgt caatattaat gttttgcttg ttagtattaa
     8701 tatttcaatt gtcaatatta gtgtcttgct tgttagtatt aatatttcaa ttgtcaatat
     8761 taatgttttg cttgttagta tcagtgtttc aattgtcaat attagtgttt tgcttgttag
     8821 tattaatatt tcaattgtca atattagtgt cttgcttgtt agtattagta tttcaattgt
     8881 caatattagt gttttgcttg ttagtattag tatttcaatt gtcaatatta gtgttttgct
     8941 tgttagtatt agtatttcaa ttgtcaatat taatgttttg cttgttagta ttagtatttc
     9001 aattgtcaat attagtgttt tgcttgttag tattaatatt tcaattgtca atattagtgt
     9061 tttgcttgtt agtatcagtg tttcaattgt caatattagt attttaattg ttgactctag
     9121 ttattgctga tatagaaaat atttaattta tttcaattaa ttagattaaa gtagggtagc
     9181 atctaaaata gctaacatgt ttaagttgaa atacgtttaa tatattaatt tttcaaagca
     9241 ttaatatatt aaagttataa tcaaaattga agttataatc tgccaaatct atagcgtatt
     9301 aagtgcgtta tataacttaa tcttttatat aaagagttaa tttttttaat ttgtaaagca
     9361 gagtacgttt aaaaggtact atttagataa tgatgtacta tctaatttta aaatatctac
     9421 aatagggttc tcttgaagac ttgctattgc ttctgcaaca gcataaacat cttcatttaa
     9481 tgcctctgct tttacatttg caaatgattt acttttaaca actgccttac ccttatcatc
     9541 aaaaccagca tccaatttta gttttatact agataaattt tttgttgaaa caacttccat
     9601 aaaattacct cctaaaaatt taatttcaaa gatttgtcga ctttctttgt tagctataat
     9661 actatcatct aagataatat cggagttaaa cagtaatttc taaagatttt ttgtgtaaat
     9721 ttttatagga aaaattttac ttttttgctg atgaaaaagt ttacaagtta tttgtgaaga
     9781 tatgttctta gtgttttgaa atagtatttg tatatattca tgcttagttg agatagtttt
     9841 gtatggattt tcatatgtgt agagttaaat gttaggtact aaagtttatg ttaaattaaa
     9901 tgttaaagct tatgttaaaa attttattaa atttaatctg taaataaaaa agttaaaagt
     9961 ccaatattaa cattttactt ttaaaccatt aaaatcttta ttaaagctaa caaagttata
    10021 agttatgaga aattttatta aagttaatac aaaaattaat tttaaagcta agaaattttt
    10081 tattagattc aataaaacta ataaatatag tttagtcaat aatgtattaa ataaaaactt
    10141 tgttaagtct ataaaaatat cttaaaggag gtgtaactta tgaagataaa agtggaggat
    10201 ataccagttc aatttcatgc aatggtagaa ataattggaa ttgataagtt tatagaggtt
    10261 gccaagttgt atggaggaac aaatacttat atacctacgt ataaggggct ttttagatat
    10321 gctagaaata gggatatagt aaaacaattt aatggagtca accacaatga attggctatt
    10381 agatataata tgtgtgtaag caatattaag cgaatactca atgaaaataa tgtttaaata
    10441 taataaaata atgtttaaac ataatgaaaa tagccttgtt aaacgtaaga gtaaagacaa
    10501 agaagatgtt ttataaagtt tttttagaca aattaactaa atttactact tattaattta
    10561 aatacattgt atattctata aaaaaatttg ttaaatactg gagatatatt gagaatacaa
    10621 agaaaatggt cgaaaatatt tgttggctaa aaaatagata aaatgataca attgcttgta
    10681 taaaggggaa aaataaataa ataaactata taaataaaga aatagcaatt aatatgacat
    10741 aatatattta taaaattaag aatataaata gatattttaa ggtattagtt gttaaattag
    10801 gaaatattaa aaaaaatata tatttatatt taaactattt tgttatttat ataaaaatac
    10861 ttatctagtt actagcaatt attagtagaa atgggggaaa tagagatgaa taagggattt
    10921 tacaaattaa attcagtggt attgaacttt gatattaaga atgatgttaa caagataaga
    10981 tttaatcatt atataatgag aaaagaaaac atacaaagac ttcaaggaac tctgccaaac
    11041 ggacaatttt atatgacagt gagaagagct gctacagatt tacaactttc tatttctact
    11101 ataagtaggc ttgtaaaaga gtttttggat ttagggataa taagattagt gtctaagggt
    11161 gtaaaaggta atcgttctgt atatagttac gtaagtatag agtttaatgg aagtttattt
    11221 gatgatagca aatatatgga acttgactgt gtatgtaatg atgaatttat tgataatagt
    11281 ggcatagagt ttgattgtga tagcaaagat aattctttta atggagatat aaatgtagaa
    11341 actgtgcatt gcattaatga gtatttgtct gatgatgatg tagagcataa ttataacaat
    11401 ttccataata aagatactat aaaggataaa gccatttcta atattagcac tatcaaaaaa
    11461 tatattgatg aatcttttga taaaaataaa tcagaaaatt ctaacttaca acaggagtca
    11521 ataaatttca actttaatga tacatgcaat gaaatagata aaagaacgaa taatagtata
    11581 gaaaataatc aaaataaaag gcctatgaga ttgagtgaca tcagtctttt aagtgataaa
    11641 ggtatgacaa ataaaaagaa ttactttaat cataatcatg gtatacaaaa agggactaaa
    11701 tctgtaacaa agaaaaaaga atccttaaat aaatttaata aaaaaaatat acagcaaagc
    11761 attataaata tgctaaataa aaaatcaggt aagaatttta aaatcgattc tccaataagc
    11821 ataaaactta tcaatgaaag gctaaaggaa ggctatgtct tagaagattt ctacaaagtt
    11881 attgaggtaa aagtggctaa gtggaaaaat accataatgg aaatgtatat aagaccagaa
    11941 actttgttta gctataagtt tgaatcctat gtaaatgaaa acatatctat gaaaagtcaa
    12001 agtaatgttc acccatgtaa agaaggcaat agtaatgata gcagtaatta tatacattct
    12061 gattatacaa catatgatgg cagtgtgcgt gagagaaaaa aatatgagaa tgtaagatac
    12121 tggaatccta tatgtgaaat ttaattagtt taagaatgta tttatgataa ataagatatt
    12181 aatagagaat agtgagctat agcaaatgat atatcaatag ttggtagtaa gttatattaa
    12241 gcaagatatt actatcaggt agtgaattat attgaacgat atatcaataa ttggtagtaa
    12301 attatattaa gtaagatatt actatcaggt agtgaattat attgaacgat atattaataa
    12361 ttggcagtaa attatattaa ataagatatt aatatcgagt aatgaattat attgaacgat
    12421 atatcaataa ttggcagtaa gttatatcaa ataagatatt aatatcgagt a
//
LOCUS       DAEPID010000102        12467 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.102, whole genome shotgun sequence.
ACCESSION   DAEPID010000102 DAEPID010000000
VERSION     DAEPID010000102.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 12467)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 12467)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..12467
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.102"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            complement(103..750)
                     /locus_tag="KR257_003339"
     CDS             complement(103..750)
                     /locus_tag="KR257_003339"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437518.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TIGR01906 family membrane protein"
                     /protein_id="HBH0032005.1"
                     /translation="MKKFLNVLFSICISIVIIVGVINFTVGFKQLYYFDIDYLNISEL
                     SGLSKDDIKLNYDYLIDYNLNKNVSEFKLPTLKSSPQGKIHFEEVRNIFQNINKLAKL
                     LLVVSLVGIILSVKNKNIKILKTTSITLIIMPLLLTVPILLNFEKSFIIFHKLLFRND
                     YWIFNPDLDPVINILPEEFFFHSGMMILILILLVSIVLFVMYKLCKSLSIKIFQC"
     gene            complement(779..2329)
                     /locus_tag="KR257_003340"
     CDS             complement(779..2329)
                     /locus_tag="KR257_003340"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018592108.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC-F family ATP-binding cassette
                     domain-containing protein"
                     /protein_id="HBH0032006.1"
                     /translation="MLVVENVSHGFGARTILENVSFRLRKGEHIALVGANGEGKSSFL
                     NIITKKLMPDAGNIKWSSRATVGYLDQHTVLSKGKTIREVLREAFKHMFDLEQEMIAM
                     YDKMGEASDDEMSKLLEETAEIQTILENSGFYMIDAKIQEVANGLGLGEIGLDKDVTD
                     LSGGQRTKVLLTKLLLENPTILILDEPTNYLDEEHITWLTKYLQEYENSFVLVSHDIE
                     FINNTCNVIYHMENGELNRYKGNYDEFVRLNDIKKRQEEQAYDKQVEERKRLEDFVAR
                     NKARVATRGMANSRQKQLDKMEILERPKEKIKPTFAFKDARAASKIIFETENLVLGYD
                     EALTKPLNFHLERGKKIALKGMNGIGKSTLLKTLLGIIKPFEGNVKLGDYLEVGYFEQ
                     ESSRENSNTPMDEVWSEFPGLTNFEVRQALAKCGLTNEHITSQMRVLSGGEAAKVRLC
                     KVMLKNINFLVLDEPTNHLDVEAKDELKKAIKEFKGTVLLVCHEPEFYSEIVDDVWNI
                     EDFTTKIV"
     gene            complement(2531..3415)
                     /locus_tag="KR257_003341"
     CDS             complement(2531..3415)
                     /locus_tag="KR257_003341"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860957.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="N-acetylmuramoyl-L-alanine amidase"
                     /protein_id="HBH0032007.1"
                     /translation="MKKYRLLVTCIIAMGIIIIGTSNPVSNFYKTTNLISSGNITNEK
                     ANKDENSNKNNKDKNEDKSNSKSNKDKSSEDKSSDNKNEIQKNKKLLICIDPGHQGKG
                     DSNLEPVAPGSSSKKARVSSGTEGIATKKPEYVLNLEASLVLKSILESKGYNVIMTRE
                     THDVNISNSERAILANDKKADMVVRIHADSLNNSSKTGASILIPEKDGKYTAPIYEES
                     NKCAEFIKQNMEQSGIQINGIVQRGDLTGFNWSKVPAVLVEMGFMSNYNEDQMMSNPD
                     YQRKMMQCIADGLDAYFK"
     gene            3643..4656
                     /locus_tag="KR257_003342"
     CDS             3643..4656
                     /locus_tag="KR257_003342"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888579.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptidase S55"
                     /protein_id="HBH0032008.1"
                     /translation="MQLKNFHFKNNTLSKKTNLAKSKFTIVLTFLFLFLLYFFSNNLI
                     YAQNLQKNEPEYLIPIGNVLQIDAELKNIIVRNPGEASPFRLGDAIVKVNNAEVDGYS
                     DFANTLNALPEEKQVSILLNRGGQLITMKTTKHILEKISFNNLLSGFATLTYINPDTS
                     EFGAVGHPISVGNARKIPIKTGSISTTKHLNIEKSYKGSVGCINAKRENIIGSFTENT
                     DFGIRGQINNFDISKLKKYKVASLDEVKLGKAQIILQDNFNKCKKYNIEIIDIENQKH
                     PESKSFKIKITDKKLLAQTGGIVQGMSGTPIVQDNKIIGAVSHAIENDPAVGYGVFIK
                     WML"
     gene            complement(4872..5570)
                     /gene="yunB"
                     /locus_tag="KR257_003343"
     CDS             complement(4872..5570)
                     /gene="yunB"
                     /locus_tag="KR257_003343"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418439.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sporulation protein YunB"
                     /protein_id="HBH0032009.1"
                     /translation="MNRIVDRKTKNEFRKIIAIFLVILFLSVFIGSFIYIDKTLRPTI
                     TVLAETKALELANRSINKAVAEMVEGKINYEDLMDIQLDNNGKITMIQANTIMMNEIA
                     SAIALEIQDELKKDKTASSYIPIGTALGSPILAKYGPKLEVSIEPIGTVSVNFKTEFE
                     SSGINQTRHRIYLEAQTQVKVVIPLITSTKQIKAQIPICETIIVGDVPESYVNIPEKN
                     LGNVLPNTGKNTNK"
     gene            5784..8477
                     /locus_tag="KR257_003344"
     CDS             5784..8477
                     /locus_tag="KR257_003344"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418435.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transglycosylase domain-containing protein"
                     /protein_id="HBH0032010.1"
                     /translation="MNNDNDKNGNKIRRKKVSSSGNTNKPINRTSANKTRSTKNKKKS
                     KKSDKFKKLRVFGIVFLVLLVVGTAGTAGLVFASLRDVTPVTEAVLDKQTNQTTTIKY
                     ANGKTLSTAPSVNKKTPVPLDKISPYLQHAVIAIEDERFYEHKGVDIKGLFRSVLKTL
                     TGTKQGGSTIPMQVSKMLLTTEQQTIPRKIKDIYYAHEMSKTVSKDKILETYLNNFFV
                     GRGLAGAEAGARGYFDKSAADLTLAESALLAGSTKNPSRFSAYKTSKLEGNETKEDLE
                     NKLLFFVNTTDDDLDDPTQVDFDMIEKIKSWELISNDTYRQLKAGTLVVRKAVSNPEA
                     KKRQEIVLKKMLELKYIKQSEYDEAIKAKIEIKLPQSSDKVSSSVEDLIESEVINALM
                     EQGHTNDEAQNLFYNGGLIVNTTIDPKMQDALEEEFDRNSNFPGHMVGPDGVSQPQAA
                     MVILDYKNGEIRALAGGRNISGRKTLNRATNPHQPGSSIKPLAIYTPAIDTLKITQAT
                     ALSDSRGGYKFKENNEWNPRTTTAGHGSMSLRKALAKSSNTIAVKTAEMLGDSYDECV
                     DIMMDYLKNFGITTLKNNHSGSSEASDRKFPSLTLGGMANGITPLQMAAAYGTLANHG
                     IYVEPSIFTTITTFDGQLLVKNAPEEHKVVDPEVAYVVTDMLESVITEGTGGVATLPK
                     GMPVAGKTGTTNSAYDAWFVGYTPYYVGATYIGDDAGRKDDSGNTIKRREVPHGSTST
                     AKLWEKIMEKIHANLTVTEFEVPKNVYFTKINLEDGGKQSSGSKAAFIEGTAPTKVSS
                     QPSSEDTKKPDNNQPEENNNNNNNTGDNGGGSTPPDNGGNNGGGSTTPPDNGGNNGGG
                     STTPPDNGGNNGGGSTTPPDNGGNNGGGSTTPPDGGGTPAT"
     gene            complement(8751..9686)
                     /locus_tag="KR257_003345"
     CDS             complement(8751..9686)
                     /locus_tag="KR257_003345"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418433.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1177 domain-containing protein"
                     /protein_id="HBH0032011.1"
                     /translation="MILKQVIEVYDILDKANANGEEVKTYLQGYGEVDVTVKELSSSK
                     GSTDLVKLTIPGKNGKLKGGDAPTLGILGRLGGIGARPEVIGFVSDGDGALVAIAVAA
                     KLLDMQRKGDILDGDVVISTHICPDAPTKEHYPTPFMDSPIDMMTMNENEVDSSCDAI
                     LSIDTTKGNRVINTRGFAISPTVKEGYILKTSDNLLDIMQTVTGKSPFVFPLSIQDIT
                     PYGNNLYHLNSILQPAVATDAPIVGVAITTEMPVAGCATGATNFSDLDSAGRFAIEVA
                     KLFGRNKCDFYDKEEWEMLIKRYGKLNRFQTFGIQ"
     gene            complement(9730..10902)
                     /locus_tag="KR257_003346"
     CDS             complement(9730..10902)
                     /locus_tag="KR257_003346"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012816045.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="M20 family metallopeptidase"
                     /protein_id="HBH0032012.1"
                     /translation="MECFKEVVNMNELKAKIKEEIKLLSEEKKTSFEKVSDYLFSNPE
                     LAFEEYKSQKALCDLLEENEFNVTKGVGGLETSFEAVYSNGTNGKTVAFLAEYDALPG
                     MGHACGHNIIGTSSVGAGIILKEIMKKHNIEGTVKVFGTPAEERVGGKITMIKEGVFN
                     NVDAALILHPSDASMPDDISFAQVNLKFDFTGKASHAAAFPWEGKSALSGVIALFNSV
                     NSMRLHLKDYARVHGIITDGGSIHNIIPEKSTAIFNVRALSIEYLNEICEMLKNCAKG
                     AAISTGTNVEIVQLDEIYKEIKNDSELVNIVRQNFEVLGEDYVERDLSQGIGSTDTGN
                     LTHEIPAIQAYIKLKENTATHTDEFAVAAGGEEGRVALIKAIKVLAMCGVDILYSK"
     gene            complement(10889..11353)
                     /locus_tag="KR257_003347"
     CDS             complement(10889..11353)
                     /locus_tag="KR257_003347"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437484.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0032013.1"
                     /translation="MEKTFKTIMEQIKIVLFIYIIICFGQMIALKTQAQDLLIGSVSG
                     FLLVIIAIIIKNFVKKPNLPGFAWATLVAFVLSLPISPVGDIIATNVGKINFMSTVTP
                     LLAFAGISVGNQLDILKTLSWKLVVISFIVMTSTYFGSAFISQTVLRLNGML"
     gene            complement(11368..12210)
                     /locus_tag="KR257_003348"
     CDS             complement(11368..12210)
                     /locus_tag="KR257_003348"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418427.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3100 domain-containing protein"
                     /protein_id="HBH0032014.1"
                     /translation="MKEKAGIRNAIIAAFIITILAELIGPISFKVMGINVTLLSILWA
                     IFIGMAVSPHLLGRVIPALKKFIGDNEINVSPYLLSLTLYPLGIMFGINAGPKVGILL
                     QAGPALLLQEFGHMGTMLIALPVGVALGLGRSALGGTFSLCRDTALGIIGDKYGLNSP
                     EGIGTLGTYISGSIFGTLLFSFLAPVGVLLGFHPYALAMASGMGSGSMMGAATASLMN
                     TVPQMSEQILAYSATSGLITAVTGIYIELFLSLPVANYYYSKVAPVIERFRGRKTRRT
                     SNKL"
BASE COUNT         4258 a         2073 c         1598 g         4538 t
ORIGIN      
        1 actttcatag tctaaatatt attgcacagc tatttttatt gtataacttt taatctaatc
       61 cttttttatt atcttatttt ggaaataaaa atatccctct atttaacatt gaaatatttt
      121 tattgataaa gatttacata atttatacat tacaaacagt actatactta ctaacaaaat
      181 taatattaaa atcatcattc cagagtgaaa aaaaaattcc tctggcaata tatttataac
      241 tgggtctaaa tcgggattaa atatccaata atcatttcta aataataatt tatgaaaaat
      301 aataaatgac ttttcaaaat ttaataaaat tggaactgtt aataataatg gcataattat
      361 aagtgttatt gatgtagttt ttaagatttt tatattttta ttttttacac tcaatataat
      421 tcctactaaa gaaactacca ataataattt agctaattta tttatatttt gaaatatatt
      481 cctgacttct tcaaaatgta tcttcccttg tggagaagat tttaatgttg gtaatttgaa
      541 ctcagacaca ttcttattta agttataatc aattagataa tcgtagttca attttatatc
      601 atctttagat aaaccagata actctgatat atttaagtaa tcaatgtcaa aataataaag
      661 ttgtttaaat ccaacagtaa aattaataac acctactatt ataacaatac taatacaaat
      721 tgaaaaaagt acatttagaa actttttcat gaaatccccc cagcaataag ttaaatcact
      781 acacgatttt agttgtaaaa tcttctatat tccatacatc atcaacaatt tctgaataaa
      841 attctggctc atgacatact aaaagaactg ttcccttaaa ctctttgata gccttcttca
      901 attcatcttt tgcctcaaca tctaaatgat ttgtaggctc atctaatact aagaaattta
      961 tattttttaa cattactttg caaagtctaa ccttagcagc ttctccacca cttaatactc
     1021 tcatttgact cgttatatgt tcatttgtaa gtccacattt tgcaagagcc tgtctaactt
     1081 caaagtttgt aagccctgga aattcactcc aaacttcatc cataggtgta ttactatttt
     1141 ctcttgaact ctcttgttca aaatatccaa cttccaaata gtcacctaat ttaacatttc
     1201 cttcaaatgg ttttattatt ccaagtaaag tttttaatag agtagatttt ccaataccat
     1261 tcattccttt taaggcaatc ttttttcctc tttctaaatg gaaattaagt ggttttgtca
     1321 atgcttcatc ataccctaaa actaaatttt ctgtttcaaa aattatttta ctagctgctc
     1381 tagcatcttt aaaagcaaaa gtaggtttta ttttttcttt tggtctttct aatatttcca
     1441 tcttatcaag ttgcttttgt ctactgttag ccattcctct agttgctact ctagctttat
     1501 ttctagctac aaaatcctct agtctttttc tttcttcaac ttgtttatca taagcttgtt
     1561 cttcttgacg tttctttata tcattaagtc ttacaaattc atcataattt cctttatatc
     1621 tatttaactc tccattttcc atatgatata ttacattaca tgtattattt ataaattcaa
     1681 tatcatgaga aactaagaca aaactattct catactcttg aaggtactta gtaagccatg
     1741 ttatatgctc ttcgtctaaa tagtttgtag gctcatccaa tataagaata gttggatttt
     1801 caagtagaag tttagtaaga agtacttttg ttctttgccc tccacttaag tcagttacat
     1861 ctttatcaag accaatttct ccaagaccaa gaccatttgc aacttcttgt atctttgcat
     1921 ctatcatata aaaaccacta ttttcaagta tagtttgtat ctctgctgtt tcttcaagaa
     1981 gcttactcat ttcatcatca ctagcttctc ccattttgtc atacatagca atcatttctt
     2041 gctctaagtc aaacatatgc ttaaaagcct ctctaagcac ttctcttata gtttttccct
     2101 tgcttaatac cgtatgttgg tctaagtaac ctactgtagc tcttgaagac cattttatat
     2161 ttccagcatc tggcataagc ttctttgtta ttatatttaa aaaactcgat tttccttctc
     2221 cattagcacc aactagtgca atatgttcac cttttctaag tctaaaggat acattttcta
     2281 atattgttct cgcaccaaat ccatgactca cattttctac tactagcatt tcaacacctc
     2341 tcaaaaaaat tttacacatt ctatactata atatattctt tttaaactta aatcaagtat
     2401 tcccaatatt tttagttata tttacgacaa tttaacctaa aataaacttc ttctttgtgt
     2461 tatgtacaat aaaaaataga gataaaaatt aggaaaataa taccaaccta actttttctc
     2521 tattcatatc ttatttaaaa tacgcatcca atccatcagc tatacactgc atcatttttc
     2581 tttggtagtc tggatttgac atcatttggt cttcattata gttactcata aatcccattt
     2641 ctactaatac agctggtact tttgaccagt tgaatccagt caaatcacct ctttgaacga
     2701 ttccattgat ttgtatacct gattgttcca tattctgttt gataaattca gcacatttat
     2761 tactttcttc atatatagga gctgtatatt ttccatcttt ttcaggaatc aatatagatg
     2821 ctccagtttt tgaagaatta tttaaactat ctgcatgtat tcttacaacc atatctgctt
     2881 ttttgtcatt agcaagtatt gctctttctg aattacttat atttacatca tgtgtctctc
     2941 tagtcattat tacattataa cctttagatt ctaatatact ctttaaaaca agagatgctt
     3001 ctaagtttaa aacatattct ggcttttttg tagcaatacc ctctgttcct gaagatactc
     3061 ttgctttttt agaggaagaa cctggagcta ctggttctaa attgctatct ccttttcctt
     3121 gatgccctgg gtctatacaa attaaaagtt ttttattttt ttgaatttca tttttattat
     3181 ctgacgattt gtcctctgat gacttatctt tattactttt agaattagat ttgtcttcat
     3241 ttttatcttt attatttttg tttgaatttt catctttatt tgctttttca tttgtgatat
     3301 ttcctgaact aatcaaattt gtagtcttgt aaaaattgct aactggattt gatgttccta
     3361 taattatgat tcccatggca attatacaag taactaacaa tctatatttt ttcatttttt
     3421 gctcctttct tatgctagac agttattgtt tatttttatt tatatgaata tgtatttatt
     3481 ttatcatata cactatttat tttatttatt tttatgaaaa ctaaggtgtt attgagctag
     3541 ttttccaagc atcaaaacat gattcttgca caacataata tagaagcagc aagaaaactt
     3601 caattctatt attaaaataa tttaataaga aagaggtgtt ttatgcaact taaaaatttt
     3661 cattttaaaa ataatacttt aagtaaaaaa accaacttag ctaagtcaaa atttacaatt
     3721 gttttaacat ttttattttt atttttatta tattttttct caaataattt aatttatgca
     3781 caaaatttac aaaaaaatga acctgaatat ttaataccaa ttggaaacgt acttcaaatt
     3841 gacgcagaat taaaaaatat catagttaga aatcctggag aagcatctcc atttagattg
     3901 ggtgatgcta tagtaaaggt aaataatgct gaagttgatg gatatagtga ctttgccaat
     3961 accttaaatg ctttaccaga agaaaaacaa gtatctattt tattaaatag aggtggacaa
     4021 cttataacaa tgaaaactac caaacacata ttagaaaaaa ttagttttaa caatttactt
     4081 tctggatttg ctactttaac gtatatcaat ccagatacat cagagtttgg agctgtaggt
     4141 catccaataa gtgttggtaa tgcaagaaaa atacctatta aaacaggttc aatttctaca
     4201 actaagcacc ttaatataga aaaatcttat aaaggtagtg ttggatgtat aaatgcaaaa
     4261 cgagaaaata ttattggtag ctttacagaa aatactgatt ttggaataag aggtcaaatt
     4321 aataactttg atatttccaa gttaaaaaaa tataaagtag catctttaga tgaagttaaa
     4381 ttaggaaaag cacaaataat tttacaagat aactttaata agtgtaaaaa atataatatt
     4441 gaaattatag atatagaaaa ccaaaaacat ccagaaagta aaagttttaa aattaaaatt
     4501 acagataaaa agcttttagc tcaaactggt ggtattgtac aaggtatgag tggtactcca
     4561 atagttcaag ataataaaat aatcggagca gtgtcacatg caattgaaaa cgacccagct
     4621 gtaggttatg gtgtatttat taaatggatg ttgtaaataa tataaataaa taaataagtt
     4681 ttaagatgtt attaagttat taataatata tttggtctaa aggtactttt atttaaccta
     4741 cagaccaaat atattagata ttttacatag tataaaatat aaatttttat taaaattata
     4801 ttaatattat ttccaaaaat tttatttata aactattatt ttgaatttat ttaaaaatat
     4861 acaactttat attacttgtt ggtattcttt ccagtgttag gtaaaacatt tcctagattt
     4921 ttttctggaa tatttacata actttctgga acatcaccta ctattatagt ttcacaaata
     4981 ggtatttgag ctttaatttg ttttgttgaa gttataagtg gtattactac tttaacttgt
     5041 gtttgagctt ctaaatatat tctatgtcta gtttgattta tacctgaaga ctcaaattcc
     5101 gttttaaagt ttactgatac tgttcctata ggttcaatag atacttcaag tttaggaccg
     5161 tatttagcta atataggact tcctaatgct gttcctatag gtatgtaaga acttgctgtc
     5221 ttatcctttt ttaattcatc ttgtatttct aaagctattg cagatgcaat ttcattcatc
     5281 attatagtgt ttgcttgtat catagttatt ttaccattat tatcaagttg tatatccatt
     5341 aaatcttcat aatttatttt tccttctacc atctcagcaa cagctttatt tatcgaccta
     5401 tttgctagtt caagagcttt agtctctgct aaaactgtta ttgtcggtct taaagtttta
     5461 tctatatata taaaactgcc tataaataca gacaagaaaa gaattactaa aaaaatagct
     5521 atgatttttc taaattcatt ttttgttttt ctatctacta ttctattcaa aattatcccc
     5581 tcctatttat ttatatgtag ctttggcata atttttataa tatttgtcaa aaataaataa
     5641 aataaaaata tagacttttt aatatattac gtttatacat atacaatgta cagaatatta
     5701 tagcaaattc attttttcta ttaattacaa aactactcct atttgtgtta taatattgca
     5761 ttaagtaagg aggttaaaat cttatgaata acgataatga taaaaatgga aataaaatca
     5821 ggagaaaaaa agttagctca tctggtaata caaataaacc aattaataga acttcagcta
     5881 acaagactcg ttcaacaaaa aacaagaaaa aatctaaaaa aagcgataaa tttaaaaaac
     5941 taagagtatt tgggatagta tttttagttt tactagttgt tggtacagca ggtactgctg
     6001 gtctagtatt tgcgtcacta agagatgtaa ctccagttac agaagctgtt ttagataaac
     6061 agacgaacca aacaactact attaaatacg ctaatggaaa aacattatct acagctccaa
     6121 gtgtaaataa aaagacaccc gttccattag ataagatttc cccttatctt caacatgctg
     6181 taattgcaat agaagatgag cgtttttatg agcataaggg tgtcgatatt aaaggtttat
     6241 ttaggtcagt attaaagacc cttacaggta ctaagcaagg tggtagtact attcctatgc
     6301 aggtatccaa aatgctgtta acaactgaac agcaaactat acctcgtaaa ataaaggata
     6361 tttactatgc acatgagatg agtaaaacag taagtaaaga taaaatacta gaaacttatt
     6421 taaataactt cttcgttggt agaggtctag caggtgctga ggctggtgca cgtggttatt
     6481 ttgataagtc tgcagctgac cttactctag cagagtcagc acttcttgct ggttcaacta
     6541 aaaatccatc aagattttca gcctataaaa cttctaagtt agagggaaat gaaactaagg
     6601 aggatttaga gaataaatta ttattttttg ttaacacaac tgatgatgat ttagatgacc
     6661 ctactcaagt ggactttgat atgattgaaa aaataaaatc ttgggagctt atatctaatg
     6721 atacttatag acaattaaaa gcaggtacat tagttgttag aaaggctgta agtaatcctg
     6781 aagctaaaaa aagacaagaa attgttttaa agaaaatgtt agaattgaaa tatataaaac
     6841 aaagtgaata tgatgaagca atcaaagcta aaatagaaat aaaattgcct caatcatcag
     6901 ataaagtttc ttcatctgta gaagacctta tcgaaagtga agttataaat gctttaatgg
     6961 aacaaggaca tacaaatgat gaagctcaaa acttattcta caatggtggt ctaattgtaa
     7021 acacaactat agaccctaaa atgcaagatg ctttagaaga agaatttgat agaaatagca
     7081 atttcccagg acatatggtc ggtcctgatg gagttagcca accgcaagct gcaatggtaa
     7141 tcttagatta taaaaatggt gaaataagag cactagctgg aggaagaaat ataagtggta
     7201 gaaaaacttt aaatcgtgct actaaccctc atcagccagg ttcttctata aaacctttag
     7261 caatatatac gccagctatt gatactctaa aaataacaca agcaactgct ctaagtgatt
     7321 ctcgaggagg atataagttt aaagaaaata atgaatggaa tccaagaact actactgctg
     7381 gtcatggttc tatgagttta cgtaaagcac ttgctaaatc ttcaaacacg atagctgtca
     7441 aaactgctga aatgcttgga gactcttatg atgaatgtgt agatataatg atggattact
     7501 taaagaactt tggtataaca actttaaaga ataatcactc aggttcatct gaagcaagtg
     7561 atagaaaatt cccatcattg acactaggtg gtatggcgaa tggtattact ccacttcaaa
     7621 tggctgctgc ttatggtaca ttggcaaatc acggtattta tgtagaacct tctattttta
     7681 ctactataac tacctttgat ggtcaattat tagttaaaaa tgctcctgaa gaacataaag
     7741 ttgtagaccc tgaagtagct tatgttgtta cagatatgtt agaaagcgta attactgaag
     7801 gtactggtgg tgttgctaca cttccaaagg gaatgcctgt agcaggtaaa acaggtacta
     7861 caaatagtgc atatgatgct tggtttgtcg gttacactcc ttattatgtt ggtgcaactt
     7921 atattggaga tgatgctggt agaaaagatg attctggtaa cactataaaa cgtagagaag
     7981 tcccacatgg aagtactagt actgcaaaac tatgggaaaa aattatggaa aaaatacatg
     8041 ctaatttaac ggttactgaa tttgaagttc ctaaaaatgt atattttaca aaaattaatt
     8101 tagaggatgg aggaaagcaa tcttctggct ctaaagcagc atttattgaa ggtactgctc
     8161 ctactaaagt aagttctcaa ccatcatctg aagatacaaa aaaaccagac aataaccaac
     8221 cagaagaaaa taataataac aataataaca caggtgataa tggtggcggt tctacacctc
     8281 ctgataatgg cggaaacaat ggtggtggct ctactactcc tcctgataat ggcggaaata
     8341 atggtggtgg ctctactact cctcctgata atggcggaaa caatggtggt ggctctacta
     8401 ctcctcctga taatggtgga aataatggtg gtggctctac tactcctcct gatggtggtg
     8461 gaactccagc aacttaataa aaaatagaat ttaaataaaa atataaggag ttgtctcaag
     8521 gtgattaaaa aaatcacttt gaaacgctcc tttttttata attacaatat attatttgta
     8581 ttcataaaaa agagaatccc aataaccaga atcctccttt ttatataaac aaataaatat
     8641 tttattttta aagtttttaa ctaagtgctt tattcttact tttattccta attgtttata
     8701 tattcttaaa tagttatatc acaaattata taaacttaat atttttctaa ttactgtata
     8761 ccaaatgttt gaaatctatt taatttgcca tatctcttaa taagcatttc ccactcttct
     8821 ttatcataga aatcacactt atttctacca aatagcttgg caacttcaat tgcaaatctc
     8881 ccagctgaat ctaaatcact aaaattagtt gcacctgtag cacatccagc aacaggcatc
     8941 tctgttgtaa ttgctactcc tactattggt gcatctgtag ctactgctgg ttgtaaaata
     9001 ctatttaagt gatacagatt atttccatat ggtgttatat cttgaataga caaagggaat
     9061 acaaatggag atttccctgt tacagtctgc ataatatcta aaaggttatc actagttttt
     9121 aatatgtagc cttctttaac agttggcgat attgcaaatc ctctagtatt gattactcta
     9181 tttcctttag tagtatctat agaaagtatt gcatcacaac tactatcaac ttcattttca
     9241 ttcatagtca tcatatcaat tggagaatcc ataaaaggag taggatagtg ttctttagtt
     9301 ggagcatctg ggcaaatatg ggttgaaatt acaacatcac catctaatat atcccctttt
     9361 cgttgcatat ccaaaagttt agcagccact gcaattgcta ccaatgctcc atcaccatct
     9421 gaaacaaaac ctataacttc tggtcttgct ccaatccctc ctagtctacc taaaatgcca
     9481 agagtaggag catctccacc ttttaatttt ccatttttcc caggaattgt aagctttact
     9541 aaatctgttg agcctttact tgaagacaat tcttttacag ttacatctac ttcaccataa
     9601 ccttgtaagt aagtttttac ttcttcccca ttagcatttg ctttatctaa aatgtcataa
     9661 acctctatta cttgttttaa tatcatgtct aatccgattt cctttcttaa tatattttaa
     9721 aattatatat tatttactat acaaaatatc tactccacac attgctaaca ccttaattgc
     9781 ttttataagt gctactctgc cttcttcacc accagctgca acagcaaatt catctgtatg
     9841 agttgcagta ttttctttta attttatata tgcttgtatt gcaggtatct catgagttaa
     9901 atttcctgta tcagttgaac ctataccttg acttaaatct ctttcaacat agtcttcacc
     9961 caaaacttca aaattttgtc taactatatt cactaattca gaatcattct taatctcttt
    10021 gtatatttca tctaattgaa ctatttctac attagttcca gtagaaattg cagctccttt
    10081 agcacaattt ttaagcattt cacaaatctc atttaaatat tctatgctta aagctcttac
    10141 attaaatata gctgtagatt tttcaggaat tatattatgt atgctacctc catcagttat
    10201 aattccatgt actcttgcat aatctttaag atgtaatctc atgctattta cactgttaaa
    10261 tagtgctatt actccactta aggcactttt cccttcccaa ggaaaagcag cagcatgtga
    10321 tgccttacca gtaaaatcaa attttaaatt aacttgagca aatgatatat catcaggcat
    10381 tgaagcatca cttggatgta aaattaatgc agcatctaca ttattaaata caccttcttt
    10441 aatcatagtt atttttccac ctactctttc ttctgcaggt gttccaaaaa cctttacagt
    10501 cccttctata ttatgttttt tcatgatttc ttttaatatg atacctgcac caacagaact
    10561 tgtccctatg atattgtgcc cacatgcatg tcccattcct ggaagtgcat catattcagc
    10621 taaaaaagca actgttttcc cattagttcc atttgaatac acagcttcaa aagatgtttc
    10681 taatcctcct acacctttag ttacattaaa ttcattttct tctaacaaat cacataatgc
    10741 tttttgtgac ttatactcct caaatgctaa ttctggattt gaaaataaat agtcagaaac
    10801 tttttcaaat gatgtctttt tctcttcaga taataacttt atttcctctt taatttttgc
    10861 ttttaattca ttcatattta ctacctcctt aaagcattcc atttaatctt aaaactgttt
    10921 gagatataaa agcagaacca aagtaagtag atgtcataac tataaatgat ataactacta
    10981 acttccaact caaagtcttt aatatatcta attggttacc tacagagatt cctgcaaaag
    11041 ctaataatgg tgttactgta gacataaaat tgattttccc tacatttgtt gctatgatat
    11101 cccccactgg agatattgga agcgataaaa caaatgcaac taatgtagcc catgcaaaac
    11161 ctggtaaatt aggtttttta acaaaattct ttattataat agcaattatc accaacaaaa
    11221 atccagatac acttccaatc aacaaatctt gagcctgagt cttaagtgct atcatttgtc
    11281 caaagcaaat aataatatat ataaacaata ctatttttat ctgctccata atagtcttaa
    11341 aagttttttc catatatata tcctccttta caatttatta cttgttcttc ttgtttttct
    11401 tcctctaaat ctttcaataa ctggagctac tttgctataa tagtagttgg ctactggtaa
    11461 agataagaat aattctatat atattccagt aacagctgta atcaatccac tagtagctga
    11521 atatgctaaa atctgctctg acatttgtgg aaccgtattc attaatgatg ctgttgcagc
    11581 tcccatcatt gaaccactac ccattcctga tgccattgct aaagcatatg gatgaaatcc
    11641 taaaagtaca cccactggtg ctaaaaatga aaataataat gttccaaata tactaccact
    11701 tatgtaagtt cctagtgttc ctataccttc tggtgagttt aatccatact tatctccaat
    11761 aattcctagt gctgtgtcac gacataatga aaaagtacca cctaatgcac ttcttccaag
    11821 acctaatgct actccaacag gtaatgctat caacattgta cccatatgac caaattcttg
    11881 taataaaagt gctggtcctg cttgaagtaa tataccaact ttaggccctg cattaattcc
    11941 aaacattatc cctaatggat atagtgtcaa agataataaa tatggagata catttatttc
    12001 attatcccct ataaactttt ttaaggctgg tataactctc cctaataaat gaggagaaac
    12061 agccattcct atgaatatag cccatagtat actaagtaaa gttacattaa ttcccataac
    12121 tttaaatgaa ataggtccaa ttaattctgc caatattgtg attataaagg ctgctattat
    12181 ggcatttcta atccctgctt tttctttcat ttctatacct ccttgtaatt tttataattt
    12241 tcttataata taattgttag tgattttatt atataaccta tcattgataa tgtataatat
    12301 atatttattc atcattttta tatactttta gttatgaatc aaaaaaatat tatagattca
    12361 tgatataaaa tacaaataat ttattaattt atattgttaa aataacggat tttcaaataa
    12421 ttgaataaaa ttattcattc atattataaa aactatctca ataaata
//
LOCUS       DAEPID010000103        12234 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.104, whole genome shotgun sequence.
ACCESSION   DAEPID010000103 DAEPID010000000
VERSION     DAEPID010000103.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 12234)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 12234)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..12234
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.104"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            631..1809
                     /locus_tag="KR257_003349"
     CDS             631..1809
                     /locus_tag="KR257_003349"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902010.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GGDEF domain-containing protein"
                     /protein_id="HBH0032015.1"
                     /translation="MKYHIFLIITTILIIELCNIYICKIASFRNKNITIHKNYKYIFL
                     IKPLTFLIIIFTKLPLPLYYILFYIVSHKLLLSRKSSTNNHFIPNMAVISFCILHLIT
                     VSTISLVKNTSPDIIFANMTYKLISILIASILDFILWYSMNKIKEHIYIITQNQIEFS
                     LFLKFIWFTLGYILFDSIQITFAPPSSLTSYFILGSNILLILQLIIFINHIYSIEKNI
                     YLEKEHNRLKMIKQEQLLKVNLLKKKANIDELTSAYNRKFAFEKIQHYIDNNLLFSLI
                     YIDLDKLKTINDTYGHLAGDNYIINFSSIVIENLGIDDIFARIGGDEFIVIMPKSNEN
                     TTKEFIEKISKIMDNTISFSYGIVEVSSENKMTVEEIINIADIRMYTNKQNNHKRNNN
                     "
     gene            2159..3040
                     /locus_tag="KR257_003350"
     CDS             2159..3040
                     /locus_tag="KR257_003350"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003432854.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GGDEF domain-containing protein"
                     /protein_id="HBH0032016.1"
                     /translation="MPAYLFDSNSIANIYRVFPISFSFIVTGLYFSYKNNKNNKINFE
                     AVLEDKKNLIFLLSLMFGMYLYLCLSLSIYYTVGNVLILKLYGIKSAIIVLVGNYIAE
                     RYSFRITQIKGYDIKNQIEYVESVKTEYEINKLNDIVYTDLLTGFYNRPFVNQKLSEW
                     TSNHYKFTLCFTDLNSLKPVNDKFGHQFGDKYISTTAQIIKKLINVENSLLFRYGGDE
                     FLFLLQNTSCVEAEKIMININYELSKISNTDEYPYALSISYGLVEWDGISDIETLISK
                     ADSLMYENKLKNKSTLN"
     gene            3231..3398
                     /locus_tag="KR257_003351"
                     /pseudo
     CDS             3231..3398
                     /locus_tag="KR257_003351"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418025.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="EAL domain-containing protein"
     gene            complement(3658..6225)
                     /locus_tag="KR257_003352"
     CDS             complement(3658..6225)
                     /locus_tag="KR257_003352"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002602373.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pyruvate, phosphate dikinase"
                     /protein_id="HBH0032017.1"
                     /translation="MIYYVLPLEHKQATIEIVGGKGMSLSKLLTAGIPVPDGFHVTTA
                     SYQIFVETNHIQSRINKLLDGIDSNNTSQLEDVSKKIGELFHNGEMPQEVSDAIKMAY
                     AGLGNISVAVRSSATAEDLPDASFAGQQETYLNIQGEDKVIDSVKRCWASLWTARAIA
                     YRVKNNIKHEIVALAVVVQKLAFSDSSGIMFTLNPINGRRSEMIINAAWGLGEAVVSS
                     LVTPDTIVVDKDSERIISYEVANKEIMTVRTSEGTEETMVPERLRKKYALTRNQVMQL
                     IQLGKKIEKYYQMPMDVEWALEKDKLYIVQARPITVLPPEWVLPEQDVVYTKGSLAEH
                     LPNPVTPLFATLGLEIVNRASELLWIDMFGKSAKKLLPKNGAYTVINGYVYLSAKSNP
                     LLIAIKSLSPRSLRRTLMNSVARWETARKGYEDAIKQWEEKPLHTMNAHQIMEGIQTI
                     FYAACIYFTRIQLTLPAASISETLFTKLFQGAVRRAGITDTSVFLLGFDTIVLQSEKE
                     LWGISEWVKQNNSINLYLQNSPAIKIAEDFMSSVVPVGVSQEVWIEWKNRINKYFKEF
                     GRTAYEFDFAHSTPQETLTPTFESVKTFVEGKGESPFLRQTTFEKRRKHAEEEILQHI
                     GGLRKKLFFKLLHWAQETSPMRENAIYLMGMGHPLIRCMFQEISERFIRGGAISHLDD
                     IYWLTKSELEVLIEQLDKNKSLSDMNGIIPVRKAELKKYMGYVSPSKLPEKNKKTISQ
                     AQQKQKDGKIVLTGIGTSTGVVTAPACVLNSPADFESFQPGSVLVAVTTTPAWTPLFS
                     SASAIVTDIGGPLSHSSIVAREYGIPAVMATHIATRAIKSGQMITVDGLAGTVTFDE"
     gene            complement(6228..6833)
                     /locus_tag="KR257_003353"
     CDS             complement(6228..6833)
                     /locus_tag="KR257_003353"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002591427.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="HBH0032018.1"
                     /translation="MPKGIVLTPEQQAERREKIVAVALSLMAENGFQKTSMREIAVLA
                     NMGKSSLYDFFKTKDEIVVYAVEKEIEKTIQQVHRIIDGEPSPQQCLRKIMLNHLRFP
                     EQYRTVLMWLNTESDYLEEEYRKRLKDARYAYQDIIKSVIDNGVTTGIFRKTDTALVT
                     RLLINSMLSISYTSRPLDSSEKMLDETMNIFLHGIMNDGGE"
     gene            complement(7207..8667)
                     /locus_tag="KR257_003354"
     CDS             complement(7207..8667)
                     /locus_tag="KR257_003354"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895591.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NADP-dependent glyceraldehyde-3-phosphate
                     dehydrogenase"
                     /protein_id="HBH0032019.1"
                     /translation="MFNELKTKENVYKNLINGKWVESNSRKPIEIYSPIDNSLVGKVQ
                     SMTKHEVDEVIKNTKESIKVWAEMPVYKRANIFHKAADLLLENIDEIANILVLEIAKD
                     IKSARAEVERTADFLRYTADVGKNMEGEAISGDNFPGGTRNKMSYVSRVPLGTVLAIS
                     PFNYPVNLSMSKIAPALIGGNAVVLKPATQGAISALHVVEIMRKAGIPDGVLNTITGR
                     GSEIGDYVVTHKGINFINFTGSTEVGQHISKISGMVPLLLELGGKDAAIVLEDADLDF
                     AAKNIVSGAYSYSGQRCTAVKRILVQESVADKLVGKIKPLVEKLTIGNPMDEVVITPL
                     IDNKATDFVQGLVDDALHKGAKLITGNVRKNNLFYPTLLDNVNVDMKIAWEEPFGPVL
                     PIIRVKDINQAIEIANQSEYGLQSSVFTSDIDKAFYIADKLEVGTVQINNKTERGPDH
                     FPFLGVKASGMGTQGVKYSIEAMTRPKAVVVNVREL"
     gene            9029..9607
                     /locus_tag="KR257_003355"
     CDS             9029..9607
                     /locus_tag="KR257_003355"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902006.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="HBH0032020.1"
                     /translation="MAKSFTEIEKDNIRKRLISECEINWSKYGYKKTNIDELCSKSGI
                     AKGSFYTFFDSKEKLFFEVLNGIQNRLISSVDEILSNMPPKEGFAKALKMLYRLYDKN
                     PFLYSPNNTDYITLLNKIPKEMLSQLEYSNVQSFYSLIERHNLKLKIEKEKAFGVCNA
                     LLSSLLLKEDIGYDYIEVFDFMVDNLVEHILE"
     gene            9658..9891
                     /locus_tag="KR257_003356"
     CDS             9658..9891
                     /locus_tag="KR257_003356"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902005.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0032021.1"
                     /translation="MIELIQRLNDIIYKINDKLNIHTKLVDPSSELMPLYSMLSIIVS
                     IFLIILGIKVRKKFLIIIAIISIIINILIILDR"
     gene            9900..11150
                     /locus_tag="KR257_003357"
     CDS             9900..11150
                     /locus_tag="KR257_003357"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888369.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MFS transporter"
                     /protein_id="HBH0032022.1"
                     /translation="MVKSSNTFNKNFNLMILGQIISLFGASILKFALSLYILDITGKA
                     EIFATILAVSSIPIIVFSPIGGAIADIFNRRNLMVIFDFSSSLTVLILAVFLFNNNGS
                     ILLVGIIMTILSVISTMYQPTVQSSTPLLVDNEHLMNANGIVAGVASLTNIAGPVLGG
                     VLYGVIGINAIIVISCVSFFLSAIMEIFIQIPFIKQEQNSNIIKTIFTDIKDGIVHIC
                     KENRFILKILFLAIAINLFLSSMLIVGIPYIVKITMGASNFLYGLAEGAISFSSLVAA
                     VSIGIFSKHLKITNLHISFIICAVMFIPMAVSVYPFILNTGFPVPFLIFIVSSMLIFF
                     TTTLISIYVITVTQLKTPNELLGKVMSILFAGTAIAMPLGQVMYGKLFDLLSDRVYII
                     ILGVGFITLLIAFVSKITLRNENL"
     gene            11311..11880
                     /locus_tag="KR257_003358"
     CDS             11311..11880
                     /locus_tag="KR257_003358"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888368.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hydrolase"
                     /protein_id="HBH0032023.1"
                     /translation="MSYMPTLEQAWEILRKYNKEEFHIRHAQIVSGVMRYYAKEYDPE
                     RVEFWEIVGLLHDLDFEMYPDEHCVKQRELMTELDLDKSIIDSTISHGYGLTGSDVKP
                     EQFMEKVLFAVDELTGLIGAAAIMRPSKSVSDLELKSVKKKFKDKSFAAGCSRDVIRS
                     GAEMLGWELDKLIQTTIEAMRSLIPEMAI"
BASE COUNT         4248 a         2011 c         1688 g         4287 t
ORIGIN      
        1 cttggacaca taactattat acttgctata tgtaattact atactttata cacatagtta
       61 ttatacatgc tatatataat tactacactt ggacacataa ctactatatt tactatatgt
      121 aattatacta tacgtggaca tatagttatc atacatacta tatgtaatta ctatacttgg
      181 acacataact attatatttg ctatgtgtaa ttatactata cttggacata tagttatcat
      241 acatactata taattactat acttggacac attatcatac atactatatg taattactat
      301 acttatacac atagttatca tatatactat atataattac tatacttgga cacatagtca
      361 tcatacatgc tatatgtaat tactatactt atacacataa ctattatact ttccatacat
      421 aattactata tttggacaca tagttatcat acatactgta tattaagata taatactttt
      481 taaattttat ataacacaga cacatgcaat aaaaaagaag gtatccataa taagctcttt
      541 gcatgtacct aaataaaaac tgtaaaatag aatatataaa atctaatcta ttttaagtaa
      601 atacaatttc actttaaaag aggatgtact atgaaatacc atatattttt aatcataact
      661 actatattaa taatcgaact atgtaacatt tacatatgca aaatagcatc ttttagaaac
      721 aaaaatataa ctatacataa gaattacaaa tatatttttt taataaaacc attaaccttc
      781 ttgataataa tattcacaaa attaccatta ccactatatt atatattgtt ttacatagta
      841 agtcataaat tgctcttaag cagaaaaagt tctactaaca accattttat tcccaatatg
      901 gcagtaataa gtttttgtat tttacacctt attactgtaa gtacaatatc acttgttaaa
      961 aatacaagtc cagatataat atttgcaaat atgacctata agttaattag tattttaata
     1021 gcttctattt tagattttat cttatggtac tctatgaata aaataaaaga gcatatttat
     1081 ataataactc aaaatcaaat agagttcagt ctatttttaa aatttatctg gttcacttta
     1141 ggatatatat tatttgatag tatacaaatt acatttgctc caccaagttc tctaacttcc
     1201 tactttatat tgggaagtaa catattatta atcttacaac taattatatt catcaatcat
     1261 atatattcca ttgaaaaaaa tatttatttg gaaaaagaac ataatagact aaaaatgata
     1321 aaacaagaac aattactaaa agtaaattta ttaaagaaaa aagccaacat tgatgaatta
     1381 acatcagcat ataatcgaaa atttgctttt gaaaaaatac agcattacat tgataacaat
     1441 ttattatttt cattgatata tatcgatttg gataaattaa agacgataaa tgatacatat
     1501 ggacatttag ctggggataa ctatattatt aacttctcaa gtatagttat tgaaaactta
     1561 ggaatagatg acatatttgc tagaatagga ggagatgagt ttatagttat tatgcctaaa
     1621 tctaatgaaa acaccacaaa agaatttata gagaaaataa gtaaaattat ggataatacg
     1681 atatctttta gctatggtat tgtagaagtt tctagcgaaa acaaaatgac tgtagaagaa
     1741 attattaata ttgctgatat tagaatgtac actaataaac aaaataatca taaaaggaac
     1801 aataactaaa atgaatattt acatgagctt acttgtagtc tcactatgtt ttttatctta
     1861 ttatctctat cattataatt tttttaaata tctggacata atgattaata actctaaaaa
     1921 taaatacaca gtatatatta tatattctat atttaattat ttaattttta ttatttgtac
     1981 ttatttaaag tttcatctaa ttataaattg gacaattttt atgttgattt tattcataca
     2041 aattaaagta acttataaaa tctccacaat aaaaaacatt ttttattcac taaactgctc
     2101 catcattggt ttagcaataa atatattttt taggtcttta atgtcaatag tgttaaatat
     2161 gccagcatat ttatttgata gtaattctat tgcaaatatt tacagagtat ttcctatatc
     2221 atttagcttt atagttacag gactatattt cagttataaa aataataaaa ataataagat
     2281 taactttgag gcagttttag aggacaaaaa aaacttaatt ttcttattga gccttatgtt
     2341 tggaatgtac ttgtatctat gtttgagttt gtcaatatac tatactgttg gaaatgtatt
     2401 gattttaaaa ttatatggaa tcaagtctgc cataatagtt ttggtaggta actatattgc
     2461 agaaagatat agctttagaa ttactcaaat aaaaggttat gatattaaaa atcaaataga
     2521 atatgtagaa agtgtaaaga cagagtatga gattaataaa ttgaatgata ttgtatatac
     2581 agatttactg acaggtttct acaatagacc ttttgtgaat caaaaactat cagaatggac
     2641 atcaaatcac tacaaattta ccttatgttt tactgattta aatagcttaa aacctgtaaa
     2701 tgataaattt ggacaccaat ttggtgataa atacatatcc actactgctc aaataataaa
     2761 aaaacttata aatgtagaaa attccttact atttagatat ggtggagatg aatttttatt
     2821 ccttttacag aatacaagtt gtgtagaagc agaaaagata atgattaata taaattatga
     2881 attatcaaaa ataagtaata ccgacgagta tccttatgct ctttccataa gctatggatt
     2941 agttgagtgg gatggaatat ccgatattga aactttaata tcaaaggcag attctttgat
     3001 gtatgaaaat aagcttaaaa ataaatctac tttaaactag ctagttcaga tattctacaa
     3061 aatatatatt ataagatagt actaagaatg tcaaaatata tagattttgc aaatattgaa
     3121 tacagtttac taatgaatgc actggatgta agtgttagta aacacctatt agatgaacac
     3181 tttactgttg tttgggctaa tgaccgttat tatgaaatgt tcggctatac ctagctaaaa
     3241 agttaaaaat gaccactgta gccgagggaa tagagactag ttttcaaaaa gatttcttgc
     3301 aagaaataga ctgtgatatg ttacaaggat acgtgttctc tagaccttta ccaataaaag
     3361 actttgaaaa acttatgttt caaaactcct ccaattaaca atataaaatt gcttattata
     3421 agtgatatta ttgtatcaac aaataaagga attgtctcaa aattgatttt ttctaatcaa
     3481 atttttattt tgagacattc tcattttttt gcataagaaa atacccacca agctacggtt
     3541 tttcttaccg ctgttcggtg ggtattagta gtattatgaa atctgaaaac tttaagtatt
     3601 actacttccg ctagcgcaat cacaaaggtc gaaagcttca aagcgaaaat aggcttttta
     3661 ctcatcaaac gtcaccgtac ctgccaaccc gtccaccgtt atcatttgtc cgctcttaat
     3721 agctcgtgtg gcaatgtgtg tagccataac ggctgggatg ccatattcac gtgcgacaat
     3781 gcttgaatgg ctaagaggac caccaatgtc cgttacaatc gcacttgcag atgaaaataa
     3841 tggtgtccat gctggagttg tggtaactgc aaccaaaaca cttccaggtt gaaagctttc
     3901 aaaatctgct ggactattca gtacacaagc tggagccgtc acaacaccag tactggtacc
     3961 aatgcccgtc aacacaattt tcccatcttt ctgcttctgt tgtgcttgtg atatagtttt
     4021 tttgtttttc tctggcaact tggatggtga cacataaccc atgtattttt taagttcagc
     4081 ttttcgaaca ggtattatcc cgttcatatc agatagagac ttgtttttat ccaactgctc
     4141 tataagtacc tccaattccg attttgtgag ccaataaata tcatctaaat gtgaaatagc
     4201 tcctcctcgt atgaatcgtt ctgagatttc ctgaaacata caacgaatca gaggatgtcc
     4261 cattcccatc aaataaatag cattttcacg cataggagag gtttcctgtg cccaatggag
     4321 caacttaaaa aatagttttt tacgcaatcc acctatgtgt tgtaaaatct cttcttctgc
     4381 atgttttcta cgcttttcaa acgtggtctg gcgtaaaaaa ggactttccc cttttccttc
     4441 cacaaatgtt tttacggatt caaaagttgg tgtaagtgtt tcctgcggtg tggaatgcgc
     4501 aaaatcaaac tcataagcgg tacgaccaaa ctctttaaag tacttattga ttcgattttt
     4561 ccattctatc catacttcct gtgaaactcc aacaggcaca actgaagaca tgaaatcttc
     4621 tgctatcttt attgcaggac tgttttgcag ataaaggttg atgctgttat tttgctttac
     4681 ccattctgaa ataccccaca actccttttc cgattgcaga acaatcgtat caaacccaag
     4741 caggaaaacg gaagtatccg ttataccagc acgtcgaact gctccttgaa ataattttgt
     4801 aaataatgtt tcactgatag aagcagcagg caatgtaagc tgaatccttg tgaaataaat
     4861 acatgcggca taaaatattg tctgaatacc ctccataatt tgatgggcgt tcatagtatg
     4921 caggggcttt tcttcccatt gtttaatagc atcctcatat ccttttcgtg ccgtttccca
     4981 gcgtgcaacg ctgttcataa gtgtcctacg taaagagcgt ggggaaaggg atttgatagc
     5041 aatcaaaagt ggatttgatt tagcagaaag ataaacatat ccattaataa ccgtatatgc
     5101 cccgtttttt ggtaataatt ttttcgcact tttaccaaac atatctatcc ataaaagctc
     5161 tgatgcacgg tttacgattt caagaccaag cgtggcgaac aaaggtgtaa caggatttgg
     5221 caaatgttct gccaaacttc cctttgtgta tacaacatcc tgttctggca atacccattc
     5281 tggtggcaga acagtaattg gacgagcctg aacaatgtac aatttatctt tttccagtgc
     5341 ccactctaca tccataggca tttgataata cttctcaatt ttctttccaa gctgtatcag
     5401 ttgcattacc tgattacgag taagagcata tttttttctc aacctttcag gaaccatggt
     5461 ttcttctgtt ccttctgaag tacgaaccgt cataatctct ttatttgcca cttcatacga
     5521 tataattcgt tcggagtcct tatccactac gattgtatcg ggtgtaacta agctagaaac
     5581 caccgcttca ccaagccccc atgcagcgtt aataatcatt tcgctacgtc taccattgat
     5641 tgggtttaac gtaaacataa taccagatga atcggaaaat gcaagctttt gtactacaac
     5701 agcaagtgcg acaatctcgt gctttatatt attcttcaca cgataagcaa tagcacgagc
     5761 tgtccataag gaagcccagc atctctttac agagtcaata actttatctt caccttgtat
     5821 gttaagataa gtttcctgct gacctgcaaa agaagcgtca ggtaaatctt cagcagtcgc
     5881 agacgaacgg acagccaccg atatgttccc taatccagca taagccattt taattgcgtc
     5941 cgacacttcc tgtggcattt ctccattatg gaaaagctcc cctattttct tagatacatc
     6001 ttcaagttgg ctggtattat tggaatcaat accatctagc agtttattaa ttcgagactg
     6061 aatatggttc gtctcaacaa aaatctggta tgaagcagtc gtaacatgaa aaccgtctgg
     6121 cacagggatg cctgctgtca atagttttga taaagacatc ccttttccac caacaatttc
     6181 aatggttgct tgtttatgtt ccagtggcaa gacataataa atcataatca ttcacctcca
     6241 tcattcataa ttccgtgcag aaatatattc attgtttcat ccaacatttt ttccgaacta
     6301 tccaatggtc gtgacgtgta gctgattgat aacatggagt taattaacaa acgtgtcaca
     6361 agagcggtat ccgttttgcg aaagatgcct gtggtcacac cattatcaat taccgatttt
     6421 ataatatctt gatatgcata acgagcatct ttaagtctct ttcgatactc ttcttctaaa
     6481 taatcagatt ctgtatttaa ccacatcagt acagttctat actgctctgg aaatctaaga
     6541 tgattaagca tgatttttct aaggcactgt tgtggtgaag gttcaccatc aataatccta
     6601 tgaacttgtt ggatagtttt ttctatttct ttctcaactg catatacaac aatctcgtct
     6661 ttcgttttga aaaaatcgta tagacttgac tttcccatgt tggctaaaac tgcaatttct
     6721 ctcattgatg ttttttggaa tccattttca gccataagac tcaaagcaac agcaactatt
     6781 ttttctcggc gttctgcttg ttgttcgggt gtaagcacaa ttccttttgg catagggcga
     6841 tacctccttt tagcgaccac tggtcgtttc ttttttattt atcatacagc gaccaacggt
     6901 cacttgtcaa ggttaatttt tttcattgta tatggtactc gagataaaaa tgttcatttt
     6961 agaaattgct ctatttaagt agaaataggc ttcatcatta gaaaacaaga ctataaattt
     7021 gagatattta tcatgttcaa atttcatcaa tatcaaagtt taagatatta ataaaaaaag
     7081 aattactaag aaataacata taaagattca aaaaaggagt tgaacttaaa attcaattac
     7141 aaaaaatcaa atttaagaca actcctttat tctttagctc tactattctt tatctctatt
     7201 tatttattac aactccctaa catttaccac tactgcctta ggtctagtca tagcctcgat
     7261 tgaatactta acaccttgag ttcccatacc agatgccttt acacctaaaa atgggaagtg
     7321 gtctggacct ctttcagtct tattatttat ttgaacagta ccaacttcaa gtttatcagc
     7381 tatataaaat gccttatcaa tatcacttgt aaatactgat gattgaagcc catactctga
     7441 ttgattagca atttcaattg cttgatttat atctttaact cttataattg gaagtactgg
     7501 accaaatggt tcttcccaag caattttcat atcaacattt acattatcta acaatgttgg
     7561 atagaataaa ttattttttc taacattgcc tgttattaac tttgctcctt tatgtaatgc
     7621 atcatcaacc aacccttgaa caaaatcagt tgctttatta tctataagag gagtgataac
     7681 tacttcatcc attggatttc caattgtcaa cttctctacc aatggcttta tttttccgac
     7741 taatttatcc gccacactct cttgtactaa aattctcttt actgccgtac atctttgtcc
     7801 tgaatatgaa tacgctccag atactatatt cttagctgca aaatctaagt ctgcatcttc
     7861 taatactata gccgcatctt ttccaccaag ctccaataat aatggtacca ttccagatat
     7921 tttagatata tgctgaccaa cttcagtact accagtaaag ttaataaaat taattccttt
     7981 atgcgttaca acataatctc ctatctcact acccctacct gtaatagtat taagtactcc
     8041 atctggtatc ccagcttttc tcataatttc taccacatga agtgcgctaa tagccccttg
     8101 tgtagcaggt tttaatacaa ctgcatttcc accaataagt gctggagcaa tctttgacat
     8161 tgataaattt acaggataat taaaaggaga tatagctaaa acagtaccta atggaaccct
     8221 tgaaacataa gacatcttat ttcttgttcc accagggaaa ttatctccac taatggcttc
     8281 accctccata ttttttccca catcagctgt gtatcttaaa aaatctgctg ttctctcaac
     8341 ttctgccctt gcagatttta tgtctttggc tatttcaagt accagtatat tagctatctc
     8401 atctatattt tctaacaata aatcagcagc cttatgaaat atattggctc tcttatatac
     8461 aggcatttca gcccatactt ttatactctc ttttgtgttt tttataacct catctacctc
     8521 atgttttgtc atagattgta ctttcccaac aagagaatta tctattggtg agtaaatttc
     8581 tattggcttt ctcgaattag attctaccca ttttccattt attaaatttt tatatacatt
     8641 ttcttttgtt ttaagttcat taaacatatt tttattcctc tctctgatat aactttgtgt
     8701 atttaaatta tagccattta ttcgttatgt aaacatttct ttttttcata aacgtttacc
     8761 tataaaaaaa ttttaagtta acgtttttct acattcttct attttaataa catactcgct
     8821 ccaaatctat ataggtcaca ctttaatatc aatatactaa tataccaata taccaatata
     8881 ccaatatacc aatataccaa tataccaata taaatattat aaacataaat cacttgacaa
     8941 atttataagt agacaatatt atatatctat gacttaaaat atttttaaag tcatagatat
     9001 catatataga tagaaaggat tgataaaaat ggctaaaagt tttacagaaa tagaaaaaga
     9061 caatataaga aaaagactaa tttcagaatg tgaaatcaac tggtctaaat atggatacaa
     9121 aaaaactaat attgatgaac tttgttcaaa atcaggaatt gcaaagggtt cattctacac
     9181 attctttgat tcaaaagaaa agttattttt tgaagtatta aatggaatcc aaaacagact
     9241 tatatcatca gtagatgaaa ttttaagtaa catgcctcca aaagaaggct ttgcaaaagc
     9301 cttaaagatg ttgtatcgat tatatgataa aaacccattc ttatattcac caaataatac
     9361 tgattacatc actttattga ataagatacc taaagagatg ctttcacaac ttgaatacag
     9421 caatgtacaa agtttttata gcttaattga aagacataat ctcaagttaa aaatagagaa
     9481 agaaaaagcc tttggtgttt gcaatgccct actgtcaagc ctattgctaa aagaagatat
     9541 tggatatgac tacattgaag tatttgattt tatggtagac aatcttgtag aacacatact
     9601 tgagtaataa tttaaaataa attttctaaa catttcttta taactaggag gagtaatatg
     9661 attgaattaa tacaaagact aaatgatatt atttacaaaa taaatgataa actaaatatc
     9721 cacacaaaac ttgtagaccc tagcagtgag ctcatgccac tttactctat gttatctata
     9781 atcgtttcta tatttctaat aatattaggt attaaagtaa gaaaaaaatt ccttataata
     9841 attgctatta tatcaattat tataaatatt ttaataatct tagataggta ggtacatata
     9901 tggtaaaatc ctcgaacact tttaataaaa acttcaactt gatgatatta ggtcaaataa
     9961 tctcattgtt tggtgcatca atacttaaat ttgctttatc tttatacata cttgatataa
    10021 ctggtaaagc agaaatattt gctactatac tagcagtatc ttcaatccca attatagtat
    10081 tctcccctat tggtggagct attgcagata tattcaacag aagaaactta atggttattt
    10141 ttgatttttc aagtagtctt acagtactaa tcttagcagt attcttattc aacaataatg
    10201 gttcaatatt acttgtagga attattatga ccatattatc agtcataagc acaatgtatc
    10261 aaccaactgt tcagtcaagt acaccccttt tagttgataa tgagcattta atgaatgcaa
    10321 atggtattgt agctggagtt gcatctctta caaatattgc aggacctgta ttaggaggtg
    10381 tcttgtatgg tgtgattgga attaatgcaa ttatagttat aagttgtgta agtttctttc
    10441 tatctgcaat tatggagata tttatacaga ttccttttat caaacaagag caaaacagca
    10501 acattataaa aactatattt actgatataa aggatggtat tgttcatata tgtaaagaaa
    10561 atagatttat actaaaaata ctttttttag ctatagcaat aaacttattt ttaagctcta
    10621 tgttaatagt tggtatcccc tatatagtaa aaatcactat gggagctagt aacttcttat
    10681 atggtctagc agaaggagca atttctttta gttcactggt agctgctgtt agtattggta
    10741 ttttctcaaa acatctaaaa atcactaatt tgcatatttc ctttattata tgtgcagtta
    10801 tgttcatacc aatggcggtt tcagtatatc catttatatt aaacacagga tttccagttc
    10861 catttttaat ctttatagta tcatctatgc taatattttt tacaacgact cttatctcaa
    10921 tatatgttat aacagtcaca caattaaaaa ctccaaatga actcttagga aaagtaatgt
    10981 caattctttt tgcaggaaca gcaattgcaa tgccccttgg tcaggttatg tatggtaaac
    11041 tttttgattt attatcagat agagtgtaca tcattatact aggagttgga tttattacat
    11101 tacttatagc atttgtatca aagataacat tgaggaacga aaatctttag atacaaagaa
    11161 tttagatata aagatttaat tttcactaat ttctgaattt aaatgcaaaa ttgtgtatca
    11221 gtatgttgac gttttagaaa ttgattgata taatcaatgg aaaataaact ttataaaaat
    11281 tcaaaatatt cagctagagg agtgataaaa atgagttaca tgccaacttt agaacaagca
    11341 tgggaaatat taagaaaata caataaggaa gaatttcata taagacatgc tcaaattgta
    11401 tctggagtta tgagatacta tgcaaaggag tacgaccctg aaagagtaga attttgggaa
    11461 atagttggac ttttacatga tttagatttt gaaatgtatc ctgatgaaca ttgtgttaaa
    11521 caaagagaat taatgacaga gcttgattta gataaatcaa taatcgattc tacaataagt
    11581 catggatatg gattaactgg ttcagatgtt aaaccagagc aatttatgga gaaagtatta
    11641 tttgctgtgg atgaacttac tggtttaatt ggtgctgctg caataatgcg tccttcaaag
    11701 agcgtttctg atttagaatt aaaatctgtt aagaagaaat ttaaagataa atcatttgct
    11761 gctggctgtt ctcgagacgt tataagaagt ggtgcagaaa tgcttggatg ggaacttgat
    11821 aagcttatcc aaacaactat agaagctatg agaagcttga ttccagagat ggcaatatag
    11881 ctcctccata catataccat agaagttaca tctttaaaga gcatttctct ttttgatgca
    11941 acttcttttt atattttgta gaataaaaag tttaatattt taaactcact atataatcta
    12001 taataaatac tataaataat ataatgtata atagtcataa actttctaac cttaaaagtt
    12061 tctaataatc aataaacaat tctaatatac aaatgtcatt atatgattta attatatatc
    12121 ttcaatttat atattaaaat aaatatatat atattaaatt cttatacacc aaatttttac
    12181 attaaacttc tatgcaccac atttatacat attaaattct tatatattaa attt
//
LOCUS       DAEPID010000104        11225 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.105, whole genome shotgun sequence.
ACCESSION   DAEPID010000104 DAEPID010000000
VERSION     DAEPID010000104.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 11225)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 11225)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..11225
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.105"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            176..1351
                     /locus_tag="KR257_003359"
     CDS             176..1351
                     /locus_tag="KR257_003359"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893536.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GGDEF domain-containing protein"
                     /protein_id="HBH0032024.1"
                     /translation="MNLEKIKKFFGFPLDKKHKDNVEKELCNYLYHTGKIICIIIVIS
                     QIIMMISISAREGGPFVTPRRQWYFYMYVTLFCVSSVFMFVFSYLWNKKKDCCTFYIN
                     LWIIYVTFFCLWGCVITLLDQLGGNDLSVFSYIMLAAAAFSVLKFGESVIVFGGCFLF
                     LNLFLPGIQTIPGNEFSNIVNTFFITSLAIFVSTMLYRNRVFTYYDKLLISQQYEEIS
                     HINNLLNDKVMTDDLTKMNNRRYLEDILQKKLISHANQEPITGMMIDIDYFKQFNDNY
                     GHQKGDYCLQNIAKVILDFTSSENEHAIRYGGEEFFICIFNCNEADAKLKSECLRKII
                     ESCNFERDDVPLKCVTVSIGVYTKKIGKTITLNEFISNCDKALYTAKEQGRNCVAFY"
     gene            complement(1524..2921)
                     /gene="asnS"
                     /locus_tag="KR257_003360"
     CDS             complement(1524..2921)
                     /gene="asnS"
                     /locus_tag="KR257_003360"
                     /EC_number="6.1.1.22"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423318.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="asparagine--tRNA ligase"
                     /protein_id="HBH0032025.1"
                     /translation="MQKEFITVKELYREKEQYIGKTVKVAGWIRTSRVSKNFGFIELN
                     DGSFFKNMQIVFDEKVENFKEVGKLAISSSILVEGELVSTEGAKQPVEIHAKSIVVEG
                     ESDSSYPLQKKRHTLEYLRTIAHLRPRSNTFSAVFRVRSIAAYAIHKFFQERNFVYAH
                     SPIITGSDCEGAGEMFRITTMDLNDIPKTEDGKIDYTQDFFGKEANLTVSGQLNAEIM
                     ALSFRNVYTFGPTFRAENSYTGRHASEFWMIEPEIVFADLEDNMELAEDMIKYVISYV
                     LENAPEEMEFFNSFIDKGLLERLNKIVNSEFIRITYTKAVELLIESGHEFEYPVEWGC
                     DLQTEHERYITEQIYNCPVFVTDYPKDIKAFYMRMNEDGKTVRAMDLLVPGVGEIVGG
                     SQREEREDVLLDRINEMGLREEDYWWYLELRKFGTATHSGFGLGFERIIMYMTGMSNI
                     RDVIPFPRTPKNAEF"
     misc_binding    complement(2998..3231)
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00230"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="T-box leader; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /bound_moiety="tRNA"
                     /db_xref="RFAM:RF00230"
     gene            complement(3400..3594)
                     /locus_tag="KR257_003361"
     CDS             complement(3400..3594)
                     /locus_tag="KR257_003361"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890435.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3787 domain-containing protein"
                     /protein_id="HBH0032026.1"
                     /translation="MESKKARALKGKDNKRLKSSLLVGNESTAAWADVEKLKPHSKVS
                     IPSIKGVEEAKDWVDNGSKL"
     gene            complement(3867..5540)
                     /locus_tag="KR257_003362"
     CDS             complement(3867..5540)
                     /locus_tag="KR257_003362"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430441.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="S8 family peptidase"
                     /protein_id="HBH0032027.1"
                     /translation="MEKSYCIIYQGDIESALQENGINRYMVLNSQLAVIYVPLDFDET
                     ILNNIIQVAWWEESEPMSSLIEITNNVNNGETITTAAETDYIYENPYNDITGRGILLA
                     VIDSGIDYLHPDFINDDGTSKVLYLWDQEANTNPPPEGFIFGSEFTRSELNIAINRND
                     GSLSQDNIGTGTLVSGILVGNGRINSQYRGITTESDLIVVKLKSYTDTYYAGRINYSV
                     SDFLAAITYVTNIARTENKPLIINLTIGVKSSAVATTSILDTFNILSSAGVVVVSGAG
                     NQGNTDIHYSGRFSSVGEVQDVIIQDGDDYALDITLNTNGPDKVGAQIISPSGEVSHD
                     IRYSPDFYIYRGKFNLENTTYAMRFIYPYITSGKENLEIRLRDIKPGVWILRLTSELI
                     INGEYDIYLPNKNLIAPDTRFLDPDSVATITMYAASDDVITVGTFNNKTDSMWIGSSK
                     GPIRGRGIKPDIVASGVDIISTYKNGTYNTGTGTGVSSSIVTGVLALLMEYLEKQDNV
                     PRLSLFTQVLKTYLILGATKLEIYTYPNVSQGYGILNLKNTIQQIANTL"
     gene            complement(5550..8948)
                     /locus_tag="KR257_003363"
     CDS             complement(5550..8948)
                     /locus_tag="KR257_003363"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018112792.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="S8 family serine peptidase"
                     /protein_id="HBH0032028.1"
                     /translation="MIIINYELIVKYNGDILRLEEELGVSVEILNSSYAIITSSNEED
                     VNILLTYPEIEFIEKPFILQTQDVQSFSSTGITGFKNRTGLTGKGTIIGIIDSGIDYT
                     LPVFRDSDGRSKILYYWDQSIQGNPPEGFREGTLYTNEDINNAIDGSMYIPISTTSLH
                     GTHVAGICATIASDARIIVVRVGNIQTDIFSRSTEFMRAIKFILDRALELRMPVTLNI
                     SYGSNEGSHRGTSLFEQYIDDMCLFWKNNIVVAAGNNADKGGHKRIRLQNNITEEVEF
                     IVGEGERILNINIWPDFVDDFSVHLVNPSNNQTQAISLTSGEIRNTLGETRITGYFYP
                     IAPYSLTRRVTLQLSSNTQITPGLWKIVFEPIDIVTGNVNIYLPTSEGLNRNTRFLIP
                     TQELTVTVPGTASRVITVGSFNSRTDIVSIFSGEGDTQLGVFKPDLLAPGEDIVSFLP
                     GGTSGALTGTSMATPHVTGVCSLFMEWGIVNGNDLFLYSQKLRALLLKGARRLSNQSY
                     PNNSSGFGFLNLSDIDLYTLSNINQDLETEDIGYRSINKSFKDEENSYKFIDGYNMQI
                     HNDLENEIYISKNASRQSGILSGIDIVHTPEFEEELAGLGMSQRFFKISDSLGVLSIN
                     NTDYNSIQRVLQLPSIIRTVSTTKMTLLGEINRGTFGGVVATEEMGVNFFKNNPNINI
                     TGRGTLISIADTGIDYLHPDFIYPDGTSKIVYLWDQTKEGTPPDGFYIGTEYTREDIN
                     RAIAENDPSLSQDEVGQGTMLSGICAGLGNVNSEYAGIAEDSELIIIKLGKIDDFYNS
                     AMLFAASQYAYKKAFELGRPLVINMSLGTSSLAGLTNRSNSEKAFFTRGLCITAGAGN
                     EGNTQTHTSGIIPYVGGSVEVELELNEDEEELSLELWLNRPDKADVIIVSPTGEESKS
                     VGISNYNKVTGLFDLEGTEYSITYIYPTTFSGQQFTNVTLKNAKRGVWKIRLVGVYII
                     TGRYNLYLPNRELLKSGTRFREVDPFYTINYPAIQDDLITIGAYNTINGSLWQSSSRG
                     PTIEDRLKPDIVAPGVNIIAAYPGNTYATITGTAAASAHAAGAAAMYFQYTFVDGRYP
                     NQAYVQKIKTFMQAGARKDSNTVYPNTNSGYGLLDVRGMFDVLR"
     gene            complement(9115..10311)
                     /locus_tag="KR257_003364"
     CDS             complement(9115..10311)
                     /locus_tag="KR257_003364"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861504.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="VWA domain-containing protein"
                     /protein_id="HBH0032029.1"
                     /translation="MFIEFFYLLRSRGLNVSLNEWMTLIEALDKGLCYSNFSNFYYLC
                     RMILIKSESDFDKFDAVFLEYFKGIEHQEEIPEEIMNWLKKPDIDLEEFERLEQNPNI
                     NLDKLRAKLEERIKEQDSPHNGGNYWIGTGGTSELGHSGKGQTGIRIGGNSTYGRAVL
                     EVAGERKYRDFRDDEVLNMRQFQVALKRLRQFSTRIDAPKTELDLDKTIEETCNNAGY
                     LKLFFEKPRKNTVKLLLLMDSGGSMRGYSTLCNTLFQSVSKSNHFKDVKIYYFHNCIY
                     DRLFTTPECWLSKSINTEWILKNIDKNYKVIIVGDASMSPSELLHIGGNYRGPYNYTP
                     GIEWLKRFKRKYSKIVWMNPELRDGWDSINYWYQTQRMIQSEFNMFPLTVKGLEKALK
                     NLMVSR"
     gene            complement(10332..11153)
                     /locus_tag="KR257_003365"
     CDS             complement(10332..11153)
                     /locus_tag="KR257_003365"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430437.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MoxR family ATPase"
                     /protein_id="HBH0032030.1"
                     /translation="MIKKEISNFRGSSDYVVSPELMASVNVAIALEKPLLIKGEPGTG
                     KTMLAQAISNELKKDLVIWNIKSTTKAQEGLYVYDTVQRLYDSQFGGEGVDDISKYIK
                     YGKLGEAFSSNQQVILLIDEIDKADLEFPNDLLWELDKMEFYINETKETVRAKQRPIV
                     IITSNAEKELPDAFLRRCIFHYIEFPDRDMMEEIVKVHFDKVEEHLLEQVMTTFYWIR
                     SLKDIQKKPSTSELIDWIQALTLSGMPIEKIEKEVPFAGILLKNNEDIESMQRHL"
BASE COUNT         3574 a         2058 c         1305 g         4288 t
ORIGIN      
        1 taaagtatta atcaataaag ttactcgaca ttatctaata aattttatct atcacaattt
       61 tagattgtta cacacaatat attttgatat aattaaatca taaacgaagt attccaaata
      121 tctaatgata gaaaggaata cttattttta tgctttattt ttaatggagg cttatatgaa
      181 cttagaaaaa ataaaaaaat tttttggatt tcctctagac aaaaaacaca aagacaatgt
      241 tgagaaagaa ctctgcaatt atctttatca tacgggtaaa atcatttgca taataatagt
      301 aatatctcaa ataattatga tgatatcaat ctcagctaga gaaggaggcc cttttgtcac
      361 accaagacgc caatggtatt tttatatgta tgtaacacta ttttgtgtat cttctgtctt
      421 tatgtttgta ttttcttacc tttggaataa aaaaaaggat tgctgtacgt tttatataaa
      481 tttatggata atttatgtga cttttttctg cctatggggt tgtgtaatta ctctacttga
      541 ccagttaggt ggaaatgacc taagtgtatt tagttatatt atgttagcag ctgcagcttt
      601 ctcagtatta aaatttggag aatcagtaat agtttttgga ggatgctttt tgtttcttaa
      661 tttattctta cctgggattc aaactatacc aggcaatgag tttagtaata ttgtcaacac
      721 attttttata acatcccttg ccatttttgt ttctacaatg ctatatagaa atcgtgtatt
      781 tacttactat gataaacttt taattagtca acaatatgaa gaaatatctc atataaataa
      841 tttacttaac gacaaagtta tgacagatga ccttactaaa atgaacaacc gtagatacct
      901 tgaagatatt ctacaaaaaa aattaatcag ccatgcaaat caagaaccta taactggaat
      961 gatgatagat atagattatt ttaaacaatt taatgataat tatggacatc aaaagggaga
     1021 ctattgtcta caaaatattg ccaaagtaat tttagatttt acaagttctg aaaatgaaca
     1081 tgctatacga tatggtggtg aggaattttt tatatgtatt tttaactgta atgaggcaga
     1141 tgctaaactt aaatcagaat gtttacgaaa aattatagag tcctgcaatt ttgagcgtga
     1201 tgatgttcct ttaaaatgtg taactgttag tattggagtt tatacaaaga aaattggaaa
     1261 gacaataaca ttaaatgagt ttataagtaa ttgtgataag gctctatata ctgcaaaaga
     1321 acagggacgt aattgtgttg cattttatta aaaggttaca tactattaca taaacctata
     1381 agtattatat cgcaaaataa aagtaatcaa attatatatt tatagtacaa taaaaataac
     1441 ttgcatatct ctaaaataga taaatatgca agtcatttta gtgtttatac ttaaagttat
     1501 ataagtttta ttatatataa ttattaaaat tcagcatttt taggagttct tgggaaaggt
     1561 ataacgtctc ttatgttaga catacctgtc atatacataa ttattctttc aaatccaaga
     1621 ccaaatccag agtgagtagc agtaccaaac tttctaagtt ctaaatacca ccaataatct
     1681 tcttctctta atcccatttc attaattcta tctaacaata catcttctct ttcttctctt
     1741 tgagaacctc ctacgatttc tccaactcca ggaactagta aatccattgc tctaacagtt
     1801 ttaccatctt cattcattct catatagaaa gcttttatat cttttggata atctgtaaca
     1861 aacactggac aattatatat ttgctccgtt atatatcttt catgctcagt ttgaaggtca
     1921 catccccact caacaggata ctcaaattca tgcccagatt caattaataa ttccactgct
     1981 ttagtatacg ttattctaat aaactcagag tttactatct tatttaacct ttctaacaat
     2041 cctttatcta taaaactatt aaaaaattcc atttcttcag gagcattttc taatacatag
     2101 cttataacat attttatcat atcttctgca agttccatgt tatcttcaag gtctgcaaaa
     2161 actatttctg gctctatcat ccaaaattct gaagcatgtc ttcctgtata agagttttca
     2221 gctctaaatg taggtccaaa agtataaacg tttctaaaag aaagtgccat tatctcggca
     2281 tttaattgac cactaactgt taaattagcc tcttttccaa agaaatcttg agtatagtct
     2341 attttgccat cttcagtttt tggaatatca tttaaatcca tagttgttat tctaaacatc
     2401 tctcctgcac cttcacagtc actacctgtt atgattggag aatgtgcata tacaaagttt
     2461 ctttcttgga agaatttgtg tattgcatag gcagctattg atcttactct aaatacagct
     2521 gaaaaagtat tacttcttgg tcttaaatgt gctatcgttc ttaaatattc aagcgtatgt
     2581 ctcttctttt gtagtggata tgaactatct gattcccctt ctacaactat gctttttgca
     2641 tgtatttcga ctggttgttt agccccttct gtagatacta actctccctc tacaagtata
     2701 gatgagctta ttgctaattt tcctacctct ttaaaatttt ctactttctc atcaaatact
     2761 atctgcatat ttttaaagaa gcttccatca tttagctcta taaatccaaa atttttagat
     2821 actctagatg ttcttatcca tccagctact tttacagtct tccctatgta ctgttctttt
     2881 tctctgtaca attcttttac tgttataaat tccttttgca ttttaaatcc tcctagtata
     2941 attgttatta atttctttta aatataattt caataaaaaa agcccttcat ccctatataa
     3001 agggacgaaa gactattact ctcgcggtac caccctagtt gtcataatga cctcttagtt
     3061 aagcaatgct taaagcctat aacggtgcct tccgtctaag tctacttact aaataagctt
     3121 tcgattagaa actccaagat gttcttcaat ataaacctcg tattgagctt tcaccatcct
     3181 caactcgcta gaactacatt ttatatctac tcttctcttc acagtattta tcttttatta
     3241 tttctgctaa ttaacaaaat tataccaatt tataaatttt tagtcaataa atttatataa
     3301 ttgatactga ttgttattta aaatataata attctacctt acataatgat aataaatact
     3361 tatcttcatt acttctttat tacttcaatt tccaaaattt tataatttac ttccattgtc
     3421 aacccagtct tttgcttctt cgacaccctt aattgaaggt attgaaactt tactatgagg
     3481 ttttaatttt tcaacatcag cccatgctgc tgtcgactca tttccaacta aaagtgaact
     3541 tttaagtctt ttattatctt taccttttaa tgctcttgcc tttttacttt ccaaaactat
     3601 cacctctatt atttattttg taatagtttt agcaatttta caaataaaat tcataagtct
     3661 aaattataat tatttttaaa ttaacatcat atcttttcaa tacttaattt atacctattt
     3721 atatacaaaa tatttacttt gtgtattcaa aatataaaac tgttttttaa ttttcatatt
     3781 tattttttat gctatttttc tactctatct aaagtatttg atacaattaa actaataatc
     3841 aattataatt ttacataggt tcttatctat agagtatttg ctatctgttg aatcgtattt
     3901 tttaaattta aaatcccata tccctgcgat acatttggat atgtatatat ctcaagtttt
     3961 gtagcaccca atattaaata tgtttttaaa acttgtgtaa acaatgataa tctcggtaca
     4021 ttatcctgtt tttctaagta ttccatcaat aaggctaaaa cacctgtgac tatagaactg
     4081 ctcactcctg ttcctgttcc tgtattatat gttccatttt tatatgtgga tattatatct
     4141 acacctgaag ctactatatc tggcttaatt cctcttcctc taattggtcc tttcgaagaa
     4201 ccaatccaca tactatcagt cttattgtta aatgtaccaa ctgtaattac atcatcacta
     4261 gcagcataca tagttatagt agctactgaa tcagggtcta aaaaccttgt gtctggagct
     4321 atcaaatttt tatttggcaa gtatatgtca tattctccat ttattataag ttctgaagtc
     4381 aatcttaaaa tccatactcc aggttttata tctcttaatc ttatctccaa attttctttt
     4441 ccagaggtaa tatatggata aataaatctc attgcataag tagtattttc taagttaaat
     4501 tttcctctat atatataaaa gtctggagaa taccttatat catgactaac ttcacctgaa
     4561 ggagatatta tctgtgctcc cactttatct ggaccattcg tatttagtgt tatatcaaga
     4621 gcatagtcat ctccatcttg tattattaca tcttgaactt ctcccacact gctaaatctg
     4681 ccagaataat gaatatctgt attcccttga tttcctgcac cactcactac taccacacca
     4741 gcactactca atatattaaa agtatctagt attgaagtag ttgctacagc acttgactta
     4801 actccaatag tcaaatttat tatcagtggt ttattttctg ttcttgctat gttagtaaca
     4861 tacgttatag ctgctaaaaa atctgaaaca ctgtaattta tccttccagc ataataagta
     4921 tctgtatatg attttaattt aactactatt aagtctgatt ctgtagtaat acctctgtac
     4981 tgagaattta tccttccatt tccaactaat ataccagaaa ctaaagttcc agtacctata
     5041 ttatcttgac tcaaactccc atcatttcta tttatggcta tatttaactc acttcttgta
     5101 aattcacttc caaaaataaa accttctgga ggtggatttg tatttgcttc ttggtcccat
     5161 aaatataaaa ctttactagt tccatcatca tttataaaat caggatgcaa ataatctatc
     5221 ccagaatcta taactgctaa taaaattcct ctccctgtta tatcattata tggattttca
     5281 taaatataat cagtttcagc tgctgttgta atggtttctc cattatttac attattagtt
     5341 atttcaatta gactgctcat tggttcagat tcttcccacc aagcaacttg tattatatta
     5401 tttaaaatag tttcatcaaa atctaaaggt acatatatta ctgcaagctg actatttaaa
     5461 accatatacc tatttattcc attttcttgt agggcagatt ctatatcacc ttgataaatt
     5521 atacaataag atttttccat aaatccctcc tatcttaaaa catcaaacat tcctctaaca
     5581 tccaagagcc catatccaga atttgtattt ggatatactg tgtttgaatc ttttctagca
     5641 ccagcttgca taaaagtttt tattttttgc acatatgctt ggtttggata tctaccgtca
     5701 acaaaagtat attgaaaata cattgcagca gcaccagctg catgtgcact tgctgctgct
     5761 gtaccagtta tagttgcata cgtgttccca ggataagcag ctattatatt aacacctggt
     5821 gctactatat ctggttttaa cctgtcttca atagttggcc ctcttgatga actttgccat
     5881 aaactaccat taatagtatt gtaggctcct atggttatta aatcatcttg aatcgcagga
     5941 taatttatag tgtaaaaagg gtctacctct ctaaatctag ttccactttt taaaagttct
     6001 ctatttggaa ggtataagtt atatcttcct gttataatat aaactcctac taatcgaatc
     6061 ttccatacac ctctttttgc attctttaaa gtaacattag taaattgctg tccagaaaaa
     6121 gttgttgggt atatatatgt tatagaatat tcagtcccct ctaaatcaaa taaacctgtt
     6181 actttattat aatttgaaat tccaacactt ttactttctt caccagtggg agatactatt
     6241 attacatcag ctttatctgg tctatttaac caaagttcta atgataattc ttcctcatct
     6301 tcatttaact ctaattcaac ttcaacagaa cctccaacat atggtattat tccagatgta
     6361 tgtgtctgtg tattgccctc atttcctgct cctgccgtta tacataaccc tctagtaaag
     6421 aacgcttttt cactattact cctattggtt aaacctgcta ggctactggt acctaaagac
     6481 atatttataa ctaatggtct tccaagttca aaagcttttt tatatgcata ctgagatgca
     6541 gcaaacagca ttgcactatt ataaaaatca tctatcttgc cgagttttat tattattagc
     6601 tcagaatctt ctgctatacc tgcatattca ctatttacat ttccaagccc tgcacatatc
     6661 ccactcaaca tagttccttg accaacttca tcctgagata gactagggtc attttctgcg
     6721 atagctcgat ttatatcttc tcgtgtatat tctgtcccaa tataaaaacc atcaggagga
     6781 gttccttctt ttgtttggtc ccataaatat actatttttg aagtgccatc tggataaata
     6841 aaatctgggt gtagatagtc tattcctgta tctgcaattg atattagagt ccctcttcct
     6901 gttatattaa tattaggatt atttttaaag aaatttacgc ccatttcttc tgttgcaact
     6961 acacctccaa aagtacctcg attaatttct ccaagtaatg tcatctttgt agtcgataca
     7021 gttcttatga ttgaaggaag ttgcaaaact cgttgtatgc tattatagtc tgtattattt
     7081 atagatagta cacctaatga atcacttatc ttaaaaaacc tttgactcat acctaaccca
     7141 gctagttctt cttcaaattc aggagtatgg actatatcta ttcctgatag tattcctgat
     7201 tgtctacttg catttttact tatataaatt tcattctcta agtcattatg tatttgcata
     7261 ttataaccat ctataaactt ataactattt tcctcatctt taaatgactt attaatactt
     7321 ctatatccaa tatcctctgt ttctaaatct tgatttatat tagatagagt gtacaaatct
     7381 atatctgata aatttaaaaa accaaatcct gatgaattat ttggataaga ttgattactt
     7441 aatctccttg ctccctttag aagtaatgcc cttaatttct gtgaatacaa aaataaatca
     7501 tttccattta caattcccca ttccataaac aatgaacaaa cccctgtaac atgaggtgta
     7561 gccatgctag ttccagttaa tgctccactt gtacctcctg gtaaaaaaga tactatatct
     7621 tcacctggag ctaataaatc aggtttaaaa acacctaatt gtgtatctcc ttcaccagaa
     7681 aatatagata ctatatctgt tcttgaatta aaactaccta ctgttataac tctacttgct
     7741 gttccaggaa ctgttacagt aagctcttga gtaggaatca gaaatctagt atttctattt
     7801 agaccttcag aagttggcaa atatatattt acattaccag ttactatatc tattggttca
     7861 aatacaattt tccataaccc aggagttatc tgtgtatttg aacttaattg tagagtaact
     7921 cttcttgtga gagaatacgg tgctataggg taaaaataac cagttattct agtttcaccc
     7981 aaagtattcc ttatctcacc tgaagttaga gagattgctt gtgtttgatt atttgatggg
     8041 tttaccaaat gtacactaaa atcatcaaca aaatctggcc atatatttat gtttaatata
     8101 cgctctcctt ccccaactat aaactcaact tcttctgtaa tattattttg aagcctaatc
     8161 cttttatgac ctcctttatc tgcattattt ccagctgcta caactatatt gtttttccaa
     8221 aataaacaca tatcatctat atattgttca aataaagatg ttcctctatg tgaaccttca
     8281 ttacttccat aacttatatt taatgtaaca ggcattctta attctaatgc cctatctaaa
     8341 ataaatttaa ttgccctcat aaactctgta cttctcgaaa aaatatcggt ttgtatattt
     8401 ccaactctaa ccactattat tctggcatca cttgcaatag ttgcacaaat acctgcaaca
     8461 tgtgtcccat gtaagctagt tgttgaaata ggtatataca tacttccatc tattgcatta
     8521 tttatatctt cattagtata taatgttcct tctctaaaac cttctggtgg atttccttga
     8581 atagattggt cccaataata taatatctta gaccttccat cactatctct aaacacaggt
     8641 agagtataat ctattcccga atcaattata ccaattatag ttccttttcc agttaaacca
     8701 gttctatttt taaatcctgt tattcctgta cttgaaaaac tttgcacatc ctgagtctgt
     8761 aatataaaag gcttttctat aaattcaatt tctggataag ttaaaagtat atttacatct
     8821 tcttcattac ttgatgttat tattgcatat gatgaattaa gtatctctac tgatacacct
     8881 aattcttctt ctaacctcaa tatatctcca ttgtatttta caattaattc ataatttatt
     8941 ataatcacct cgacttctaa aattattatt aatgtatatg ttttgtgtga gtctaaaatg
     9001 tattagacta tataattttt taagtttcag ttatacaatt tataataggt atattaaaaa
     9061 aataaataat gatggtacaa ttttgaataa atcataccat catttatatt tactttatct
     9121 tgaaaccatt aaatttttca atgctttctc aagacctttt acagtcaatg gaaacatatt
     9181 aaattcactt tgtatcattc tttgagtttg ataccaataa ttaattgaat cccatccatc
     9241 tctaagttct ggattcatcc atacaatttt actgtacttt ctcttaaacc ttttaagcca
     9301 ctctatacca ggtgtgtaat tatatggacc acgatagtta ccaccaatat gaagcaactc
     9361 agaaggcgac atagaagcat ctccaacaat tataacttta tagtttttat ctatattttt
     9421 taatatccat tcagtattaa tagatttact taaccaacat tcaggtgttg taaataatct
     9481 atcataaata cagttatgga aataatatat ctttacatct ttaaaatgat ttgatttact
     9541 tacagactga aataatgtat tacataaagt gctataccct ctcattgaac cacctgaatc
     9601 cataagcaat aaaagcttca ctgtattttt tcttggcttc tcaaaaaata actttaaata
     9661 tcctgcatta ttacaagtct cttcaatagt cttatccaaa tcaagctctg tctttggagc
     9721 atctattcta gtagaaaatt gacgaagtct ctttagtgca acttgaaatt gacgcatatt
     9781 taaaacttca tcatctctaa aatctctata ttttctttct cctgcaactt caagaacagc
     9841 tctaccataa gtagaatttc cacctatacg tataccagtt tgcccttttc ctgaatgtcc
     9901 taactctgaa gtgcctcctg tgcctatcca ataattacca ccattatgag gagaatcttg
     9961 ttcttttatt cgttcctcca atttagctct taatttatca agatttatat ttggattttg
    10021 ttctaatctt tcaaactctt ctaaatctat atctggtttt ttaagccaat tcataatctc
    10081 ttctggaatt tcttcttggt gttctatacc tttaaaatac tccaaaaaca ctgcatcaaa
    10141 cttatcaaaa tcactttcac tttttattaa aatcatcctg caaagatagt aaaaatttga
    10201 aaagtttgaa tagcacagtc ctttatccaa tgcttcaatt aaagtcatcc attcatttaa
    10261 agatacattt aatcctcttg acctcaataa ataaaaaaat tcaataaaca taattatcca
    10321 gctcctatta actataagtg tctttgcata gattcaatat cctcattatt cttaagtagt
    10381 attcctgcaa aaggaacttc tttttctatt ttttcaatag gcattccact caaagttaat
    10441 gcttgtatcc agtctattaa ctctgatgta ctaggctttt tttgtatgtc ctttaaactt
    10501 ctaatccaat aaaaagtagt cattacttgt tccaataggt gttcttctac tttatcaaaa
    10561 tgtactttaa ctatttcttc catcatgtct ctatcaggaa attctatata atgaaatatg
    10621 catcttctta aaaaagcatc tggaagttct ttttccgcat ttgaagttat aataactatt
    10681 ggtctttgtt tagctcttac agtttctttt gtctcattta tgtaaaactc cattttatcc
    10741 aattcccaaa gcaagtcatt tggaaattct aaatccgcct tatctatttc atctattaaa
    10801 agaattactt gttgatttga gctaaaggcc tctcctagtt taccatattt tatgtacttg
    10861 ctaatatcat ctacaccttc tcctccaaat tggctatcat aaagtctttg aacagtatca
    10921 tatacataaa gcccttcttg tgcttttgta gttgatttta tattccaaat tactaaatct
    10981 ttttttaatt catttgaaat tgcttgtgct agcatagttt tacctgttcc aggttcgccc
    11041 ttaatcaaaa gtggcttttc aagagcaata gcaacattaa ctgatgccat caattctggt
    11101 gatactacat aatcactact tcctctaaag ttagatatct ctttttttat cataaatcct
    11161 actcctttta aacagtattt tctaaatgta tatagacttt attactattt ttgatataaa
    11221 aataa
//
LOCUS       DAEPID010000105        11136 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.106, whole genome shotgun sequence.
ACCESSION   DAEPID010000105 DAEPID010000000
VERSION     DAEPID010000105.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 11136)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 11136)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..11136
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.106"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            391..2886
                     /locus_tag="KR257_003366"
     CDS             391..2886
                     /locus_tag="KR257_003366"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902013.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding protein"
                     /protein_id="HBH0032031.1"
                     /translation="MPENNNQLLEEITLLLNEGKVAINKAENQNLILILGGTGCGKST
                     AINYLAGCVMMEVEDEDTGISYIDCLDPVAEIGSGAVSQTLYPNIVNMRKPIEGMDAK
                     LCDTAGFSDNRGVAHDISAAVSLGEVFKNSASICAVIVLIPEADILDSRLTKVLDLFQ
                     QLNMCLHKENFKGSITFFISKSFLGRTEKQIYNVIKRKYEQLCENLDSNIEEKAWLFE
                     ELLKDNGKNIHLCKPLASDEREGLLKQVLELDEVKDKTSAFQYPISADARLVLDTLIK
                     EIQNNIVSSLEDYVKAYTEDFINIIGSITMIQEIAKYDEVVKVFKNWLESTTSLTIER
                     FINVLAKQSGLFLQDSCMKLQNKIKGNLDIIDALSKYTEHGTGEILLPSVHMEFIIEK
                     ASKKIMEQNFIIIRKNLEKVLVSYEVQKQVFTLPNREKLMEVANKKDYVYSVSDFNSI
                     LTNVTVTQNEELEDSITRLSAYGEEGNEIIREFIGKYILNPFIVKTININDKKGIEIR
                     ALIPNLVISSVLEYFKNRKVDDNVSTFMFFAKDTIYMDDNLGMNFASEKNIILASNNL
                     DVGSNVKINVSGKSGELVDNSMYGKNGEDGRDAGNIYLYIKEEIRNYRLTLIANGGNG
                     SKGIDGENGETGASGSNGADAGYTSYFHGQMFKGYFEKGTSGKKGEKGGAGGNAGRGG
                     NAGKKGNIYFISDSEEQKNRIINHCDITVKDGEAGPNGRPGLGGYGGSGGYHGYNTLS
                     FSPSGIDKTVYYTGYFTSWDYKLDSIIKYHIEFSGGSWNEGKTGPAREYAEYGDRGDN
                     GGFNAPNTKLSTAVSKVEENLIKEKYQGYCSEI"
     gene            2901..8111
                     /locus_tag="KR257_003367"
     CDS             2901..8111
                     /locus_tag="KR257_003367"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438922.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosome-binding GTPase"
                     /protein_id="HBH0032032.1"
                     /translation="MANKLYSEIVNLLEEGRDELRKYDLKEKSILLFLGASGVGKSTC
                     INYLKGCVMEEKTDEETGQIYITAKDSAVEIGNGVYSKTLCPEVVDIANRDFSLCDCP
                     GFFDNRGAEYMIAGAMLVRETISTSSKVKGMVVILDYQSLLDSRHTLLIETGKNLKDM
                     LGDYAKYKENFFFLINKIPKTLIGNVTEEKIRNILEKAKEDLDSQEKDYDGCKELVYL
                     LNVALSDGVSIKLCNPLDKQPEKLLDEMKNLPETFEKTDLGLMLTASCKIEIQKAVDV
                     TYKDLEKLLVPYIESVKKGMEDSISILSSINSLKDKKIQLDKMYTDLCSRTNNMKEIM
                     EFVQELSYGDGVQKVNILEETRLLLELNSYCSETHIVGLSELLKSLLKNTLEDTLKDI
                     KYWIAEEEYREEEAKKLEDAEYRIEKIQSCTYIKSYEKENVLSIYIPIPKVNLSDLTK
                     IISGYQLNILSSIYMYGDCELKIDCNMEKEVFSGKNIVLLTEKLHIPEGTYSINVSGK
                     DAEKLVGESSIYDGMNGRNGNNAGTSGDIILSFKEIEKRGELKLYVDGGRGGNGQDGK
                     KGDTGITGEAGANAKIGSKKESKEFANVKGTKYYVVKAEKGKQGGTGGTGGNGGNAGL
                     GSKSGQVYLLGKAPLLKSAISKKDGNHGLAGKGGSGGAGGAGGLGGIRGIYEETIRYI
                     GTSPPMDNSDRNYYYFDRYVFNHALNQKQAADDGEKLNALYEEHKDWIISKREDSGSA
                     GAEGTAGHSGDALKEKELLKQEYSLSIDTFFYEFFERFGFSGIKGYRNLRLLCAVGIL
                     EADILELSHIYEIFHAVEKIEMQLNREILQKYYSFEKKNKAVLSLDDMNTKKEFYKEA
                     KEIYEYLINKLMQSDRIESFVGKNQNFSEWSMILFALEQKTAFYVQMIEESEIGGNRV
                     TDIRSLTDYLDKTLRELEQGKKDELKEGYFNTYKESILTQIESGNQQIEVLKNELENK
                     MLSVNAKMNLLIQEIIKMKEDEQEDIEELKKKQAKLEEQMKTQLILSGIQSALSLLTA
                     FSGVGQACLGAFDSAKSLKENLSAKEEEYKWTNRMVNFSDFKLDSDGMRFVLGEQLSE
                     DRKNALDKMTYNLAGVDEERRTKFDQIKEIIVKSIDDDNYADKADDIQRAKEGLSESE
                     YKEIYTKIQKKEIGMLEANYNNKQQKDKLAALEKSKQAIERQQKTSKIKNALSIGSSA
                     CSLINTAISGVNNCLNVKSSFESKIEVVKEAIKDKENNIKKLDELNTQMVEFKDKTLK
                     ESVIPFVEKFDSTVKNQDIFENEISKLKMKEVLTELSTKFGSLKMENSEEISIIFKKV
                     QDMMETQIIITDKIDKKKDNLAMGELIYQMSDSGNQMNEYQKKLIHQIELNQVRYLCQ
                     VEAAAFQLWTFPFGSNIVNILNRCHVGITEDENEVINQAKEQNRQIREFLDQDAYQWQ
                     KTDNHILKVALTGSLDGKSRVGFENTYSLYDCNEEEVKKLLTGDEISFEVPLNKNFDA
                     IKYVTMYANIPNLRRNILEDSLKVKVHIHLYDSGYFSLYDDKKDVYYQYVFPQNYINI
                     THGLDVKYNDSDSINSIWSSVEDKGIEKFKNAGLNSGRSPYSMAKISLKAHFNKKLSY
                     DSLTNEQKKKLESYFDKPSKYAWSDSIDILKSLGYIDFKGILSKSWYEIKKDIDSDGE
                     IMKHFSILQVDLLERIIYEQTSILKENIPNLTIELVGCGIYVESEFNYLKQNDLKCYE
                     ERLVENTIIG"
     gene            complement(8336..10435)
                     /locus_tag="KR257_003368"
     CDS             complement(8336..10435)
                     /locus_tag="KR257_003368"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729454.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="heavy metal translocating P-type ATPase"
                     /protein_id="HBH0032033.1"
                     /translation="MNFYIKHEIRGRIRFDLQLGKLNNKQSDTLLYYLTSINGITKAK
                     VYDRTGDAVIYYNGEREYIIREITKFSFNNSKIENLVPEHTSRELNNYYRDKLANKLL
                     VKSISKIFFPKSLRFFLIGLHSIKYFKKGLSSLLNKKIEVSVLDATAIGISIFRKDIN
                     TAGSVMFLLGIGELLEEWTRKKSIDDLAQSMSLNIEKVWLRKGDTEILIPISEIKEGD
                     LVSVTMGNMIPLDGVIVSGEAMVNQASLTGESLAVNKKEGSYIYAGTVIEQGNIVMCV
                     KEKAGTTRFQKIVTMIEESEKLKSSVESKFEHLADTLVPYSFLGSILTYAITRNPIKS
                     LSILMVDFSCALKLSIPISVLSAMRECNNNNITVKGGKFLEGVACADTIVFDKTGTLT
                     KAQPTVSDIITFQNYNKEDMLRLAACLEEHFPHSIANAVVYEAEKQGLSHKEMHTEVE
                     YIIAHGISTKVDDKKVVIGSKHFVFEDEKCTIPDGEEDKYNNLSDEYSHLFMAISGKL
                     SAVICINDPLRKEAKYVISNLRECGIKKIVMMTGDSEKTAKSIASKVGVDEYYSEVLP
                     EDKANFVKSEKLKGRKVIMIGDGINDSPAISESDVGIAMSEGAEIAREISDITISADN
                     LNNLIVLKQISNKLMKRVDLSSKFIIGFNLGLILLGVGGFVRPSTSAFLHNASTVGIS
                     LNSMTNLLENTNTYNYH"
     gene            complement(10478..10873)
                     /locus_tag="KR257_003369"
     CDS             complement(10478..10873)
                     /locus_tag="KR257_003369"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429546.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0032034.1"
                     /translation="MNILKMKKTGIFLGGVLFGTVGVKILSSDCVKKTCTRATAGALK
                     VKDSVLETTTKIQENVEDILAEAKEINEQEDLSTSKVNVVQDTLKCEQEVLKTETIKT
                     VEDTNSNSIKCEEIKDNVIEEKNSTCTTE"
BASE COUNT         4238 a         1301 c         2034 g         3563 t
ORIGIN      
        1 ataaaatatt caagctggta taggtgtaaa acttaagcag tagtatagga atgtttaaat
       61 taatggtaca aatataatta aaaatctata tgtaataacc acaggaaaat aatggacata
      121 taatataaaa aacaactgta ttacataaaa tacaataaaa taagcgcatt aaataaaata
      181 actgtgttga taaagattat attatacaac acagttattt taataaacaa agaagaataa
      241 ttattgagtg aaaatacaaa tttagtgaaa atgcaaattt attaaaaata aaaaataaaa
      301 aacaaattta aatatagtat aaaaactttg caatctactt aagggattaa actttattta
      361 aataaaatat ataaccaagg gggaaaataa atgccagaaa ataacaatca acttttagaa
      421 gaaataacac tcttattaaa tgaaggaaaa gtagcaataa ataaggctga aaatcaaaat
      481 ttaattctaa ttcttggtgg gacaggatgt ggcaaaagta ctgcaattaa ctatcttgca
      541 ggatgtgtaa tgatggaagt agaagatgaa gatactggta tatcatatat tgattgctta
      601 gaccctgtgg cagagattgg ttcaggagct gtttctcaaa ctttataccc gaacattgta
      661 aatatgagaa aaccaataga aggaatggat gcaaaattat gtgatactgc aggttttagc
      721 gacaataggg gagtagccca tgatattagt gcagcagttt cattaggtga agtatttaaa
      781 aattctgcat ctatatgtgc agtaattgta ttgataccag aagcagatat attagattct
      841 agacttacaa aagtactaga cctgttccaa cagttaaata tgtgtcttca taaagaaaat
      901 tttaagggta gtataacttt tttcatttca aaaagtttct taggaagaac agaaaaacaa
      961 atatataatg ttataaaaag aaaatatgaa caattatgcg aaaatttaga cagtaatata
     1021 gaggaaaaag cttggttatt tgaagaattg ctaaaagata atggaaaaaa tattcatctt
     1081 tgtaagccac ttgcatcaga tgagagggaa ggcttattaa agcaagtact agaattagat
     1141 gaagttaaag ataagacatc agcattccaa tatccaatta gtgcagatgc aagattagtt
     1201 ttagatacgt tgataaaaga aattcaaaac aatatcgtat ctagcctaga agattatgtt
     1261 aaggcgtata cagaagattt tatcaatatt attggaagta taacaatgat tcaagaaata
     1321 gcaaaatatg atgaggttgt aaaagtattt aaaaactggt tggaaagtac aacaagtctt
     1381 actatagaga gatttatcaa cgtattagcc aaacaaagtg gattattctt acaagatagt
     1441 tgcatgaaat tacaaaataa gataaaagga aacttagata taattgatgc tttaagtaaa
     1501 tatacagaac atggaactgg ggaaatttta ttaccttctg tacatatgga atttattata
     1561 gaaaaggcaa gtaagaagat aatggaacaa aacttcatta taataagaaa gaatttagaa
     1621 aaagttttag tttcttatga agtgcaaaaa caggtattta cattaccaaa tagagaaaaa
     1681 ttaatggaag ttgcaaataa aaaggattat gtatatagtg taagtgattt taattcaatt
     1741 ttgacaaatg ttacagttac acaaaatgaa gagttagaag acagtataac aagattaagt
     1801 gcatatggag aagaaggtaa tgagataatt agagaattta ttggtaaata cattttaaat
     1861 ccatttatag taaaaacaat taatattaat gataagaaag gtattgaaat aagagcatta
     1921 attccaaact tagtaattag cagtgtattg gaatatttca aaaatagaaa agtagatgac
     1981 aatgtttcta catttatgtt ctttgctaaa gatactattt atatggatga taaccttgga
     2041 atgaactttg catcagagaa aaatattatt cttgcttcta acaatcttga tgtaggtagt
     2101 aatgtaaaaa ttaatgtaag tggaaagagc ggagaacttg tagataattc tatgtatggg
     2161 aaaaatggtg aagatggtag agatgcaggt aatatttact tatatattaa agaagaaatt
     2221 agaaattatc gtctaacact gattgcaaat ggaggaaatg gttctaaagg aatagatggg
     2281 gaaaatggtg aaacaggagc ttctggaagt aatggagctg atgcaggata tacaagttat
     2341 ttccacggac agatgtttaa agggtatttt gaaaaaggta caagtggcaa aaaaggtgaa
     2401 aaaggtggag ctggtggaaa tgctggaaga ggtggaaatg ctggtaagaa aggtaatatt
     2461 tacttcattt cagattcaga ggaacaaaaa aatagaataa ttaatcattg tgatataaca
     2521 gtgaaagatg gagaagcagg tccaaatggt agaccaggtt taggtggata tggaggaagt
     2581 ggtggctatc acggatataa tacactttca ttttctccaa gtggtataga taagactgta
     2641 tactatacag gatattttac aagttgggat tataagttag atagtataat taaatatcat
     2701 atagaattta gtggtggaag ctggaatgaa ggtaaaacag gaccagcaag agaatacgct
     2761 gaatatggag atagaggaga caatggagga tttaatgctc caaacactaa gttatcaaca
     2821 gctgtttcaa aggtagaaga gaatcttatt aaagaaaaat atcaaggcta ttgttccgaa
     2881 atatagaaag ggatggatgt atggcaaata aactttatag tgaaatcgta aaccttttgg
     2941 aagaaggaag agacgagctt agaaaatatg acttaaaaga aaagtcaatt ttgttattct
     3001 taggtgcttc aggcgttgga aagagtactt gtataaatta tttaaaaggc tgtgtgatgg
     3061 aagaaaaaac ggatgaagag actggacaaa tatatataac tgcaaaagat tcagctgtcg
     3121 aaattggaaa tggtgtatat tctaagactt tatgtccaga agttgtagat attgcaaata
     3181 gagatttttc attatgtgat tgcccaggtt tttttgataa ccgtggagca gagtatatga
     3241 ttgctggtgc tatgcttgta agggaaacta tttccacatc ttcaaaggta aaagggatgg
     3301 tagttatttt agactatcaa tccctactgg actctagaca tacattattg atagaaacag
     3361 gcaaaaattt gaaagatatg cttggtgatt atgcaaagta taaagaaaat ttcttctttc
     3421 ttatcaataa aatacctaaa acactaattg gtaatgtaac agaagaaaaa ataagaaata
     3481 tattggaaaa agcaaaagaa gacctagata gtcaagagaa agattacgac ggttgtaagg
     3541 aattagtgta cttattaaat gtagcattat cagatggtgt atctattaaa ttatgtaatc
     3601 cactagataa acagccagaa aagttgttgg atgaaatgaa aaatctacct gaaacatttg
     3661 aaaaaacaga tttggggttg atgcttactg cttcttgtaa aatagaaata caaaaagctg
     3721 ttgatgtaac ctataaagac ctagaaaaac ttttagttcc ttatatagaa agtgttaaaa
     3781 aaggtatgga agattctatt tccattctat cttctataaa tagtctaaaa gataaaaaga
     3841 ttcaattaga taagatgtat acagatttat gtagtaggac taataatatg aaagagatta
     3901 tggagtttgt acaagaactt tcatatggtg atggcgtaca gaaagtgaat atattagaag
     3961 aaacacgtct tcttttagag ttaaatagtt actgtagtga gactcatatt gttggtctaa
     4021 gtgagttgtt aaaatcattg ctaaaaaata ctttagaaga tacattaaaa gatatcaaat
     4081 attggatagc agaagaagaa tatagggaag aagaagccaa aaagcttgaa gatgcagagt
     4141 ataggataga gaagattcaa agttgtacat atataaaatc atatgagaaa gaaaatgtac
     4201 tttctatata tattcctata cctaaagtga atttatcgga tttgactaaa ataatatctg
     4261 gttatcaact taatattttg tcatctatat atatgtatgg agattgtgag ttgaaaattg
     4321 actgtaatat ggagaaagaa gtcttctcag gtaagaatat tgtactactt acagaaaaat
     4381 tacatatacc agaagggact tattcaatca acgtatctgg taaggatgca gaaaaattgg
     4441 ttggagaaag ttctatttac gacggaatga atggaagaaa tggcaataat gcaggtactt
     4501 caggtgatat catattatct tttaaagaaa tagaaaaaag aggagaactt aaactttacg
     4561 tagatggtgg acgtggtgga aatggacaag atggaaaaaa aggagataca gggataactg
     4621 gagaagctgg ggcaaatgct aaaataggtt ctaaaaaaga gtcaaaagaa tttgctaatg
     4681 ttaaaggtac aaaatactat gtggtaaaag cagaaaaagg aaaacaaggt ggaactggag
     4741 gcacaggagg taatggtgga aatgcaggtc ttggaagcaa gtctggacag gtttatctcc
     4801 ttggaaaagc tcctttatta aaaagtgcta taagtaaaaa agatggaaat catggtttag
     4861 caggaaaagg aggctctgga ggagctggtg gtgcaggagg tcttggtgga attagaggta
     4921 tatatgaaga aacaataaga tatataggta cctctcctcc aatggataat agtgatagaa
     4981 actactatta ttttgataga tatgtgttta atcatgcttt aaatcagaag caagcagcag
     5041 atgatggaga gaaattaaat gctctttatg aagaacataa ggactggata attagcaaac
     5101 gtgaagattc aggttcagcc ggagcagagg gaacagccgg tcactctgga gatgcactaa
     5161 aagaaaagga attgttaaag caggagtatt ctttgtcaat agatacattc ttctatgaat
     5221 ttttcgagag atttggtttt tctggaatta aaggttatag aaatcttaga ctgttgtgtg
     5281 cagtaggaat tttagaagct gatattttag aactttcaca tatttatgaa atttttcatg
     5341 cagttgagaa aatagagatg caattaaata gagaaatact tcagaagtac tatagttttg
     5401 agaagaaaaa taaagcagta ctttctctgg atgatatgaa tacaaagaaa gaattttata
     5461 aagaagcaaa ggaaatctat gaatacctta taaataaatt gatgcagtct gatagaatag
     5521 aatcttttgt aggaaaaaat cagaatttta gcgaatggag tatgatttta tttgcacttg
     5581 agcagaagac agcattttat gtgcagatga ttgaagaaag tgaaattgga ggaaatcgtg
     5641 ttacagatat tcgttctttg acagattatc tggataagac cttaagagaa ttggaacaag
     5701 ggaagaaaga tgagttaaaa gaaggatatt tcaatacata taaggaaagt atcctaactc
     5761 aaattgaatc tggaaatcaa caaatagagg ttttaaaaaa tgaacttgag aataaaatgc
     5821 tttctgttaa tgcaaaaatg aacctgttga ttcaagaaat tataaagatg aaagaagatg
     5881 aacaagaaga catagaggaa ctaaaaaaga aacaggcaaa acttgaggaa caaatgaaaa
     5941 cacagttaat tctttctgga atacaaagcg cattgagttt actgactgca tttagtggtg
     6001 ttggtcaagc ttgtctaggg gcatttgaca gtgcaaaatc tttgaaggaa aatctttcag
     6061 ctaaagaaga ggaatacaaa tggactaaca ggatggttaa tttttcagat tttaaattgg
     6121 attctgatgg tatgagattt gtacttggag aacagctaag tgaagataga aaaaatgctt
     6181 tagataaaat gacttataat ttggcaggtg ttgatgaaga aagaagaact aaatttgacc
     6241 aaattaagga gattatagtt aagtctatag atgatgataa ttatgcagac aaagctgacg
     6301 atattcaaag agcaaaagag gggttaagtg aaagcgagta taaggaaatt tacacaaaaa
     6361 tccagaaaaa agaaataggt atgttggagg caaattacaa taataaacag caaaaagata
     6421 agttagctgc actagagaaa agtaaacaag ctattgaaag acagcaaaag acatctaaaa
     6481 ttaaaaatgc attgagtatt ggaagttctg cttgttctct tataaatact gcgattagtg
     6541 gtgttaataa ttgtcttaat gtaaaatcta gttttgagag taaaatagag gtagttaaag
     6601 aggcaattaa agataaagaa aataatatta agaaattaga tgaattgaat actcaaatgg
     6661 tggaatttaa agataaaact ttgaaagaat ctgttatacc atttgtagaa aaattcgata
     6721 gtacagttaa aaatcaagat atttttgaaa atgagataag taaattaaag atgaaggaag
     6781 ttttaactga attaagcaca aagtttggaa gcttaaaaat ggaaaattca gaggagattt
     6841 ctataatatt taaaaaagta caggatatga tggaaactca aattatcatt actgataaga
     6901 ttgataagaa aaaagataat cttgcaatgg gagaattgat ttatcaaatg tcagatagtg
     6961 gtaatcagat gaatgaatat cagaaaaaac ttatccatca aattgaatta aatcaggtta
     7021 gatacttgtg tcaggttgag gcagcagctt ttcaactatg gacattccca tttggaagca
     7081 atatagtaaa tatcttaaat agatgccatg tagggattac agaagatgaa aacgaggtta
     7141 taaatcaggc gaaagagcaa aatagacaga ttagagagtt tcttgaccaa gatgcttacc
     7201 aatggcaaaa aacagataac catattttga aggtagcatt aacaggcagt ttagatggga
     7261 aatcacgtgt gggatttgaa aatacatatt ctctatatga ttgtaatgaa gaagaagtga
     7321 aaaagctttt gacaggagat gaaattagtt ttgaagttcc attaaataaa aactttgatg
     7381 ccataaaata tgtaaccatg tatgcaaata tcccgaacct tagacgaaat attttagagg
     7441 atagtttaaa agtaaaggtg catattcatt tatatgatag tggatacttc tctctatatg
     7501 atgataaaaa agatgtctat tatcaatatg tatttccaca aaactatata aatattacac
     7561 atggtcttga tgttaaatac aatgattcag attcaataaa ctcaatatgg tcttcagtag
     7621 aagataaagg aattgaaaag ttcaaaaatg caggattaaa ctctggtaga agtccatatt
     7681 ctatggctaa gatttctttg aaggcacatt ttaataagaa gctttcttat gattcactta
     7741 caaatgagca gaagaagaaa ctagagtcat actttgataa acctagtaag tatgcatgga
     7801 gcgatagtat agatatattg aagagtctag ggtatattga ttttaaggga attttgtcaa
     7861 agagttggta tgaaatcaag aaagatatag atagtgatgg ggagattatg aagcattttt
     7921 ctatattaca agttgattta ttggaaagaa ttatttatga gcagactagt atactaaagg
     7981 aaaatatacc taatttgaca attgaattgg taggctgtgg tatttatgta gagtctgaat
     8041 ttaattatct aaagcaaaat gatttaaaat gctatgaaga aagattggtt gaaaatacaa
     8101 ttattggttg aaaatataat taatatataa attttaaaga aatttacaaa aggggatgtt
     8161 tcaaaatgaa aatttgaatc atctcctttt ttgtaaaaaa tagaaataag ttgagtttaa
     8221 aatttgtaaa gtatgcttta tataattttg attagaaaaa agctaatttt aagacatatt
     8281 tttttaaaaa gatgaattat aaatttttta tatcatatgt tttatgtaat ggagattaat
     8341 ggtagttata agtattggtg ttttccaata aatttgtcat actgtttaaa cttattccga
     8401 cagtagatgc gttgtgtaaa aaggcagatg tacttggtct aacaaatcca cctacaccaa
     8461 gtaaaatcaa acctaaatta aagccgataa taaacttaga acttaaatca actcttttca
     8521 taagcttatt actaatctgc tttaaaacga ttaaattatt caaattatct gctgatatgg
     8581 taatatctga aatctctctt gctatttcag caccttcact cattgcaatt ccgacatctg
     8641 attctgaaat agcaggagaa tcattgattc catcaccaat cataattact ttgcgacctt
     8701 tgagtttttc acttttaaca aaattggctt tgtcttctgg taagacttct gaataatatt
     8761 catcaacacc aactttactt gctatagatt tagctgtttt ttcgctatct ccagtcatca
     8821 tcacaatctt ttttattccg cattctctta aatttgaaat tacatatttt gcttcttttc
     8881 gtaaagggtc atttatgcaa ataactgctg ataatttacc tgatattgcc ataaataggt
     8941 gtgaatactc atctgataga ttattgtact tatcctcctc accgtctggg atagtacact
     9001 tctcatcttc aaatacaaaa tgtttgctac ctattacaac ctttttatca tcaacttttg
     9061 ttgaaatgcc atgagcaata atatattcta cttctgtatg catttctttg tgactaagcc
     9121 cttgtttttc agcttcataa actactgcat ttgctatgga gtgtgggaag tgttcttcta
     9181 agcaagctgc aagtcttaac atatcctcct tattataatt ttggaatgta attatatctg
     9241 aaacagttgg ttgagctttt gttaatgtgc ctgtcttatc aaatacaata gtatctgcac
     9301 atgcaacacc ttcaagaaat tttccacctt ttacagtaat gttgttattg ttacattctc
     9361 tcatggctga tagtactgaa atagggatag agagttttaa tgcacaagag aaatctacca
     9421 ttaatataga gagtgatttt atagggtttc tagtaattgc ataggttaat atacttccta
     9481 aaaagctgta tggaactaat gtatctgcta gatgttcaaa tttactctct acagaagatt
     9541 ttagtttttc agattcctca atcatagtta ctattttctg gaatctagta gtaccagctt
     9601 tttccttgac gcacataaca atattgcctt gctctattac agttccagca tatatgtaag
     9661 atccttcttt tttgttaact gcaagggatt cacctgtaag tgatgcctga ttgaccattg
     9721 cttctcctga tactataact ccatccaatg gaatcatatt tcccatagtt acacttacta
     9781 aatctccttc ctttatctct gaaattggaa ttaggatttc agtgtcacct tttcttaacc
     9841 atactttttc aatgtttagt gacatacttt gagccaagtc gtctatagat ttttttctag
     9901 tccattcttc taatagttca ccgataccaa gaagaaacat aactgaacca gccgtattga
     9961 tatcttttct aaaaatagaa atacctatag cagtggcatc taaaacagaa acttctattt
    10021 ttttatttag cagggaagag agaccttttt taaaatattt tatagaatga agtccaatta
    10081 aaaaaaatct taaggacttt ggaaaaaata ttttggagat acttttgact agcagtttat
    10141 ttgctaattt gtctctataa taattgttta attccctgct ggtatgttca ggaactaggt
    10201 tttctatttt gctattgtta aaactgaatt tagtgatttc tcttattatg tattctcttt
    10261 caccattgta ataaatgact gcatcaccag ttctatcgta aacttttgct ttggtaatac
    10321 catttataga agttaaataa tataagagag tatcggactg cttgttgttt aatttgccaa
    10381 gttgtaagtc aaagcgtata cgacctctta tttcgtgttt tatataaaaa ttcaatttac
    10441 ttcctcctga tattattaat cataataatc attaaatcta ttctgttgta caagtactat
    10501 ttttttcttc aattacgtta tctttgattt cttcacattt aatgctatta gaattagtat
    10561 cttctacagt ttttatagtt tcagttttaa gaacttcttg ttcgcattta agagtatctt
    10621 gtacaacgtt taccttagat gtagataagt cttcttgctc gttgatttct tttgcttcag
    10681 ctaaaatatc ttctacattt tcttgaattt tcgtagttgt ttcaagaaca gaatctttaa
    10741 ctttcaatgc tcctgctgtt gcacgagtgc aagttttttt aacacaatca cttgaaagta
    10801 tcttaacacc tacagtacca aaaagtactc ctcctaaaaa tatccctgtt tttttcattt
    10861 ttaaaatatt cattttacat tatcctttca tttagttaga ttttgtttgt acttatgtat
    10921 aaggtaacaa atgttaaaaa tagagtatgt tttacaaaat tagtttagag agtttagtaa
    10981 ttttatttga tttatattag taaatttaca tgaattttac atatgtagtt tatatagttg
    11041 aaataattct tatatagctt atatatgcag tttatatatc tagtttatat atctagttta
    11101 tatatctagc ttatgtatat aatttacata tgtagt
//
LOCUS       DAEPID010000106        11034 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.107, whole genome shotgun sequence.
ACCESSION   DAEPID010000106 DAEPID010000000
VERSION     DAEPID010000106.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 11034)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 11034)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..11034
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.107"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            154..921
                     /locus_tag="KR257_003370"
     CDS             154..921
                     /locus_tag="KR257_003370"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424252.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YoaP domain-containing protein"
                     /protein_id="HBH0032035.1"
                     /translation="MQIIDININNIDNEHICCSISEKKGENCVFSKKAWMKNNFDKGL
                     VFKRFDVRGKAFIEYIPAENAWCPITADNYIFINCFWISGKFKGQGYSNLLLQECVDD
                     AKSKGKYGLVVLSSSKKMPFLSDAKYLKYKDFCLADTSEPNYELLYFPFTDNAPIPCF
                     KNCVKQRKLNENGIVLYYSNQCPHTEKYAPILKKIANSRGIDVNLIKFETAKEAQNAP
                     APFTTYSLFFNGEFVTNEILSEKKIEKFLDTNIKKFN"
     misc_binding    1139..1352
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00230"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="T-box leader; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /bound_moiety="tRNA"
                     /db_xref="RFAM:RF00230"
     gene            1606..2640
                     /locus_tag="KR257_003371"
     CDS             1606..2640
                     /locus_tag="KR257_003371"
                     /EC_number="1.2.1.38"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861435.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="N-acetyl-gamma-glutamyl-phosphate reductase"
                     /protein_id="HBH0032036.1"
                     /translation="MNKIKVGIIGATGYVGAELIRLLMNHDKVEVTAIGSNSYVGKDI
                     VDIYPSIGYKNNMICIENEKVIDMCDVVFTALPHGVSEKFVIKAIKSKKKVIDLGADF
                     RIKDEEVYSKWYGVSFIDKILHKKAVYGLSEIYKEDIKDADIIANPGCYPTSISLPLM
                     PLLSSKLIKNNNIIIDSKSGLTGAGRELSISSHFTEVNENITAYKIGKHRHTPEIEQN
                     LSESCKEKVSVVFTPNLIPVNRGILSTIYCTKEDNISINDIHRKLTDYYEFKEFIEIL
                     PLDKIASLKNVRFSNKCVISLHENGDTLIICSAIDNMIKGAAGQAIQNMNIIFGIEEN
                     TGLKNIAPSF"
     gene            2681..3898
                     /gene="argJ"
                     /locus_tag="KR257_003372"
     CDS             2681..3898
                     /gene="argJ"
                     /locus_tag="KR257_003372"
                     /EC_number="2.3.1.1"
                     /EC_number="2.3.1.35"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893402.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional glutamate
                     N-acetyltransferase/amino-acid acetyltransferase ArgJ"
                     /protein_id="HBH0032037.1"
                     /translation="MEIIKGGVTVSEGFFASGIHCGLRKNKEKRDLALVYSDVLCDAA
                     AVVTQNKVKGNPVYVTQEHIKNGKAQAIIVNSANANTFNGKEGLINAYKMAKFTSDKL
                     NIKESDVLVASTGVIGKPLNIDLIEENMDELVNNLSKQGHIGAREAIMTTDIIKKEIA
                     VAIMYGDKKITIGGMAKGSGMIHPNMATTLGFITTDANIDGVLLKEALKIAVDKSFNR
                     VSVDGDTSTNDMVMILANGKAKNDRINKKDEHYQVFLSALTYVCIELAKLVAKDGEGC
                     TKLIECYINGALSEAHAVKLAKTVISSSLVKTAVFGADANWGRILCALGYAGEEIDME
                     KVDIIFESMKGYIEVCKNGNGLDFNEEKAKKILEDDEISILVDLNMGNARGNAWGCDL
                     SYDYVRINGSYRN"
     gene            3913..4773
                     /gene="argB"
                     /locus_tag="KR257_003373"
     CDS             3913..4773
                     /gene="argB"
                     /locus_tag="KR257_003373"
                     /EC_number="2.7.2.8"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890002.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="acetylglutamate kinase"
                     /protein_id="HBH0032038.1"
                     /translation="MINIEKANTLIEALPYIEKHQGKTIVVKYGGSAMKKDGLKESVM
                     EDLVLMSYVGINIVLVHGGGAEINKMLAKVDIESKFVNGLRYTDEETMEIVKMVLAGK
                     VNKDLVNKIHTKGGKAVGLCGIDNNMILCDPYKNYELGFVGEIKKVNVELIESCLKSG
                     YISVIATIGVGDDGETYNINGDTAASAIAKELNADKLILLTDVPGLLREPDEEKSLIT
                     EVILEDVDKLFEEGIITGGMIPKIEGCVDALNNGVNRVHILDGRVPHSIITELFTDSG
                     IGTLIRKENE"
     gene            4803..5990
                     /locus_tag="KR257_003374"
     CDS             4803..5990
                     /locus_tag="KR257_003374"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897185.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aspartate aminotransferase family protein"
                     /protein_id="HBH0032039.1"
                     /translation="MNNDNTISKWNEYFIDTYNQPNFVIDYGEGSCFFDTNGNKYIDF
                     TSGYGVSSLGYSNSNLKNALKEQVDKLLHTSNLYFNEPVLYSGEKIINSSGMAKVYFC
                     NSGTEANETAFKIARKYSSDKYGNGRGTIISLKDSFHGRTMMSLMATGMDKYHKYFYP
                     LPEGFKYVERNNIEDLKNNLDSTVCAIILEAIQGEGGVNVLEKDYVLEIVKICQEKDI
                     VVIFDEVQCGIGRTGKLFGYEYFDVKPDIVTVAKGLGAGIPVGGVLVNKKLSKVLGKG
                     DQGTTFGGNLLAMVAASVVLDEISKDGFYNEVLEKGNYIRKSIESFNNKVVLKTKGIG
                     LMIGIETNIESSIIEEKARKKGLLILTAGKNVLRFLPPLTISYKEIDEALEILKDILL
                     EIN"
     gene            6099..7121
                     /gene="argF"
                     /locus_tag="KR257_003375"
     CDS             6099..7121
                     /gene="argF"
                     /locus_tag="KR257_003375"
                     /EC_number="2.1.3.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428932.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ornithine carbamoyltransferase"
                     /protein_id="HBH0032040.1"
                     /translation="MNNISLKGKSFLTLKDFTKEEIRYLLTLSSYLKTKKKVGIKGDL
                     LQGKNIALLFEKTSTRTRCSFEVAAHDEGAHVTYLGPNDCHMGKKESVSDTAKVLGRF
                     YDGIEFRGFKQETVESLAKYSGVPVWNGLTDEYHPTQILADFLTVIENVDKDLNKVKF
                     VYVGDARNNMGNSLMIGCAKMGIHFVALAPKELWPNEELVKEMKEIAKKSKGDIMLTE
                     NIDDVKGADVIYTDVWVSMGEEEQYEARINQLKDYQVNMDMIKKTENENVIFLHCLPA
                     FHDLETKVAQEIYEKFGLSELEVTNEVFNSKYSKVFEEAENRMHTIKAVMVSTMTDVN
                     MNNNLI"
     gene            7248..7865
                     /locus_tag="KR257_003376"
     CDS             7248..7865
                     /locus_tag="KR257_003376"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435178.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4878 domain-containing protein"
                     /protein_id="HBH0032041.1"
                     /translation="MKKIILALTTFLLAISLTACSSAKPEDTIDSFFNSAKKFDFEGM
                     NKVMENNDEKYKDILKELDTKDPNAQYVLDYLKQNASKITYTIKDSEVKGDKATIKVE
                     CKFIDSTPLLQEIVAEAFTKMIGMSFSGQDLTDEKTTEMLVSIMKEKQKSVKETYVTK
                     NVEFECSKKDNKWIISSVNDAVADVLLSNLVTAGQEFSNSMNTLE"
     gene            complement(8085..8783)
                     /locus_tag="KR257_003377"
     CDS             complement(8085..8783)
                     /locus_tag="KR257_003377"
                     /EC_number="5.1.1.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428930.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amino acid racemase"
                     /protein_id="HBH0032042.1"
                     /translation="MNEKLIGILAGMGPRSTAPFVDLIIDECQSQYGAKYDDEFPKMM
                     IYSLPTPFYIDRPINHELMKETIIDGLQKLESTGVNFIAMPCNSAHIYFKELKESINI
                     PILNIVEETVKKLPTISQKVTLFSTSSTFESTIYQNGIIHNGHEFIFKDEWQIKLNNL
                     IQNIKMDKENPHNIDIWNKLIEDVKNESIENIVIACTDLNVVLEKSYPSINIVDSSKC
                     LAESVVNKYLKLVK"
     gene            complement(8945..10162)
                     /locus_tag="KR257_003378"
     CDS             complement(8945..10162)
                     /locus_tag="KR257_003378"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428929.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="M20 family metallo-hydrolase"
                     /protein_id="HBH0032043.1"
                     /translation="MLGKKCMDYLQTLGKISSTTNGLTRLILTQEHKKSIDLISSWME
                     GLNLDIEIDDIGNVIGTYKSSFPNAPTLVVASHQDSVKCGGIFDGMLGIIVPLVGLEE
                     AKHNNRSYPFNIKLIAFAEEEGTRFETSLMGSKVFAGTFKEELLKSVDENGITLEEAV
                     TKFGFNTKNLTNLHPRKDVDAYLEFHIEQGPVLENESLPAGIVSSITGFKSFKISVNG
                     KSGHAGTLPMNMRLDAGCCACECVLAIEKVAKTTADLVATVGKMNFYPSSSNVVPERA
                     EFTLDVRSCSQEILDNSVEKIFNEISHICENRKLNYTSELAFENVPVPCSNKITKIIE
                     KSFIDLNLNPFYIYSGAGHDAQEMDNITDIGMVFIRCAGGVSHNPNESVSVDDLDTAV
                     KIFLKILDNLDLK"
     gene            complement(10353..10766)
                     /locus_tag="KR257_003379"
     CDS             complement(10353..10766)
                     /locus_tag="KR257_003379"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009905693.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HBH0032044.1"
                     /translation="MELEITEKIEKQDEDTIFQGLLKYNLARLEDKNPVDLGIYIRDK
                     AGKIVAGFIGVTHGNWLSIKYLWVSEKLRYKGTGSQLLYKAEKIAKERGCKYVFLDTF
                     SFQAPKFYEKFGYHKVFSLENYPLTGKRYYFRKIL"
BASE COUNT         4336 a         1194 c         1823 g         3681 t
ORIGIN      
        1 ttatatatac aatttaataa ttcagataat cttaaaataa tattatgtaa aataaaaata
       61 tatatgacat gatgttgttg tattcaaaat attaagataa aaatatatag aatatattta
      121 aaaattatta tgcaattaga aaaggagata agtatgcaga ttattgatat aaatataaat
      181 aatattgaca atgaacatat atgttgttca atttctgaaa aaaaaggaga aaattgtgtt
      241 ttttctaaaa aagcttggat gaaaaataat tttgataaag gtctagtctt taaacgattt
      301 gatgtaagag gtaaagcttt tatagaatat attccagcag aaaatgcatg gtgtcctatt
      361 actgcggaca attatatatt tattaactgt ttttggatat ctggaaaatt taagggtcaa
      421 ggatattcta atctattgct acaagagtgt gttgatgatg caaaatcaaa aggtaaatat
      481 ggattagttg tgctttcgtc tagtaaaaaa atgccttttt tatctgatgc taaatatcta
      541 aaatataagg acttttgttt agcagataca tcagaaccaa attatgagct attatatttt
      601 ccctttactg ataatgctcc tattccatgt tttaagaatt gtgtaaaaca aagaaaatta
      661 aatgagaatg gtatagtttt atattacagt aatcagtgtc cacatacgga aaaatatgct
      721 cctattttga aaaaaattgc aaattctaga ggtattgatg taaatcttat aaaattcgaa
      781 acagcaaaag aagcacaaaa tgctcctgca ccatttacta catacagtct tttttttaat
      841 ggtgaatttg taaccaacga gatactttct gagaaaaaga ttgagaaatt tttagatacc
      901 aacattaaaa aatttaatta aaaagagatg taaatattgt attttgaaaa tatattattt
      961 tataatttaa tatattttgg atgtttttta aattgacgaa tgaaatataa aaattatatc
     1021 gcaatttaga tacaaaatgc tggaaattaa ccatatagaa aatatttcca aaaatttaaa
     1081 aattatattg acaaagttaa aaaaataaac tatcatataa aacaataaga aaataaattg
     1141 aaatcctgtg aaaaagagag tagcataaag ctagttgata gagagctggg aatggtggaa
     1201 gcctagtaac gaattttatt gtgaatagag ctttggagga gattaccaga agtaatagta
     1261 tggtaattgg tgaatctcgc cttaagagat tagagtgggt aagattatct tatcaattag
     1321 agtggtaacg cgggtgtata ttcgtctctt ggtctttgac caagaggctt ttttaatttt
     1381 aaatgtacat tttgtagata ctttttaatt tgagttttaa tgattattgt aattttacca
     1441 ataagagtgg taccgcggaa aatcgcctct tagtatttat aatgctaagg ggttttttgt
     1501 tttaattaga gtattttaat ctacgtatta tcaaatgatt atcatatagt aaagtggaaa
     1561 gataggattt taagactatt tgaatataaa aatggaggga acaaaatgaa taaaataaaa
     1621 gttggtatta ttggtgcaac tggatatgtc ggggcagagt tgattagatt attaatgaat
     1681 catgataaag tcgaagtgac agcgataggt tcaaattcgt atgttggaaa agatatagtt
     1741 gatatatatc caagtatagg atataaaaat aacatgatat gtatagaaaa tgaaaaagtt
     1801 atagatatgt gtgatgttgt gtttacagcc cttccacatg gagttagtga aaagtttgta
     1861 ataaaggcaa ttaaatcgaa aaagaaagtt atagatttag gtgctgactt tagaataaaa
     1921 gatgaagaag tatatagtaa atggtatgga gtatctttta tagataaaat cttacataaa
     1981 aaagctgtat atggattaag tgaaatatac aaagaagata taaaagatgc agatataatt
     2041 gcaaatcctg gatgttatcc aactagtatt tctttaccat tgatgccatt actaagttct
     2101 aaattgataa aaaataataa tataataatt gattctaaat caggtcttac aggtgctggt
     2161 agagaattat cgattagtag tcactttacg gaggttaatg aaaatatcac tgcatataaa
     2221 atagggaaac acagacatac tccagaaata gaacaaaatt taagtgaatc ctgcaaagaa
     2281 aaagtaagtg tagtttttac accaaactta atcccagtaa ataggggaat cttatcaact
     2341 atatattgta caaaagaaga taatatttct ataaatgata tacataggaa attaactgat
     2401 tattatgaat ttaaagaatt tatagaaatt cttccattag ataagatagc ttctttaaag
     2461 aatgttagat tctcaaataa atgtgtaata tcattacatg aaaatggaga tacattgata
     2521 atctgttcag ctatagataa tatgattaag ggagcagcag gtcaagctat acaaaacatg
     2581 aatataatat ttggtattga agaaaataca ggtttaaaaa atattgcacc atcattttag
     2641 aaataaaaaa tactaaactc atataattag gaggataaat atggagatta taaagggtgg
     2701 agttacagtt tcagaaggat tttttgcttc agggattcac tgtggcttga gaaaaaataa
     2761 agaaaaaaga gatttagctt tggtttattc agatgtttta tgtgatgcag cagcagtagt
     2821 aactcaaaat aaagtaaagg gcaatcctgt ttatgttaca caggaacaca ttaaaaatgg
     2881 aaaagcacaa gctatcatag taaatagtgc taatgctaat acctttaatg gaaaagaagg
     2941 acttataaat gcttataaaa tggctaaatt caccagtgat aaattaaata ttaaagaaag
     3001 tgatgttttg gttgcatcta caggtgttat aggaaagcca ttaaatatag atttaataga
     3061 agaaaatatg gatgaattag tgaataatct aagtaaacaa ggtcatattg gagcaagaga
     3121 agctattatg acaactgata ttataaaaaa agaaatagca gtagcaataa tgtatggaga
     3181 taaaaaaata actattggag gtatggcaaa aggttctggt atgatacatc ctaatatggc
     3241 aacaacgtta ggatttataa ctacagatgc aaatattgat ggagttttgc taaaagaagc
     3301 tttaaaaatt gctgttgaca aaagttttaa tagagttagt gtagatggag atacaagtac
     3361 taatgatatg gtaatgattc tagcaaatgg aaaagcaaaa aatgatagaa taaacaaaaa
     3421 agatgaacat tatcaagtat ttttgagtgc acttacatat gtctgtatag aacttgctaa
     3481 acttgttgca aaagatggag aaggatgtac aaaactaatt gaatgctata taaatggagc
     3541 attaagtgaa gcacatgcag taaaattagc aaaaacagtt atatcttctt cattagtaaa
     3601 gacagctgta tttggagctg acgcaaattg gggtagaata ctgtgtgctt taggttatgc
     3661 aggtgaagaa atagatatgg aaaaagttga tattattttt gagagtatga aaggatatat
     3721 tgaagtatgt aaaaatggaa atggattaga ttttaatgag gaaaaagcaa aaaaaatcct
     3781 tgaagatgac gaaataagta tattagtaga tttaaatatg ggcaatgcca gaggaaatgc
     3841 atggggatgt gatttaagct atgattatgt aagaataaat ggaagttata gaaattagga
     3901 ggatatactt taatgattaa tatagaaaaa gcaaatacac ttatagaagc tttaccatat
     3961 atagaaaaac atcagggaaa gactattgta gttaagtatg gtggaagtgc aatgaaaaaa
     4021 gatggtctaa aagaatctgt tatggaagac cttgtgttaa tgagttatgt tggaatcaat
     4081 atagttttag tacatggtgg aggggcagaa atcaataaga tgctagcaaa agtggatata
     4141 gaaagtaaat ttgtaaatgg tcttagatat acagatgaag agaccatgga aattgtaaaa
     4201 atggtacttg ctggaaaggt taataaagac ctagtaaata aaatacatac aaaaggtgga
     4261 aaagcagtag ggctttgtgg aatagataat aatatgattt tatgtgaccc atataaaaat
     4321 tatgaacttg gatttgtagg agaaatcaaa aaagtaaatg ttgagcttat agaatcttgt
     4381 ctaaagtcag gttatatttc agtaattgca actataggtg ttggagatga tggagagact
     4441 tataatataa atggtgacac agcagcttct gctatagcta aagagttaaa tgcagataaa
     4501 ttgatacttc ttacagatgt ccctggtttg ttaagagagc cagatgaaga aaaatcatta
     4561 ataacagaag ttatattaga ggatgttgat aaattatttg aagaaggtat aattactgga
     4621 ggtatgatac ctaaaataga gggatgcgta gatgccttaa ataacggagt aaatagggta
     4681 catattttgg atggaagagt tccacattct ataataacag agctatttac tgatagtgga
     4741 ataggtacat taataagaaa agaaaatgaa taaaattata agtttaagag gggagaataa
     4801 gaatgaataa cgacaataca atttcaaaat ggaatgaata ttttatagat acatataatc
     4861 aacccaattt tgtcatagat tatggtgaag gaagttgttt ttttgatact aatggcaata
     4921 aatatataga ttttacaagt ggatatggag tatcttctct tgggtatagt aatagtaatt
     4981 taaagaatgc tctaaaagag caagtagata aattattaca tacttcaaat ttatatttta
     5041 atgagccagt gttgtattca ggagagaaaa taattaattc aagtggaatg gctaaagtat
     5101 atttttgtaa ttctggaaca gaagcaaatg aaacagcatt caaaatagca agaaagtata
     5161 gtagtgacaa atatggtaat ggtagaggaa ctatcataag tttaaaagac tcttttcatg
     5221 gtagaacaat gatgtcttta atggcaactg gtatggacaa ataccataag tatttttatc
     5281 ctcttcccga aggttttaaa tatgtagaaa gaaataatat tgaagattta aaaaataatc
     5341 ttgattccac agtttgtgca ataattcttg aagcgattca aggcgaaggt ggagttaatg
     5401 ttcttgaaaa agattatgtt ttggaaatag taaaaatatg tcaagaaaag gatattgtag
     5461 tgatttttga tgaagtccaa tgcggtatag gaagaactgg taaacttttt ggctatgaat
     5521 attttgatgt aaaaccagat atagttaccg tagcaaaagg gttgggagca ggaataccag
     5581 taggaggagt attagtaaat aaaaaacttt caaaagtact aggaaaagga gaccaaggta
     5641 caacttttgg aggtaattta ttagctatgg tggcagcttc agttgtatta gatgagatat
     5701 ctaaagatgg tttttataat gaagtattag aaaaaggaaa ttatataaga aaatctattg
     5761 aaagttttaa taacaaagtt gtattaaaga caaaaggtat tggtctaatg ataggaattg
     5821 aaactaatat tgaatctagt attatagaag agaaagctag aaaaaaagga ttgcttattt
     5881 tgactgctgg aaaaaatgta ttgagatttt taccaccatt aacaatcagt tataaggaaa
     5941 tagatgaggc tcttgaaatc ctaaaagata tattactaga aattaactaa atattcaaga
     6001 aatagttgat taaagataaa aattagaagt aaataaaaaa gtaaagtgct aacaagttta
     6061 attgaattta aaaagtttat aagaaggggc gaattaatat gaataatata agtttaaaag
     6121 gtaagagttt tttgacatta aaggatttta caaaagaaga gattagatat ttattaactt
     6181 tatcaagtta tttaaaaact aagaaaaaag ttggtataaa aggcgatttg ctacaaggaa
     6241 aaaatatagc tttattattt gagaaaacat caacaagaac tagatgttca tttgaagtag
     6301 cagctcatga tgaaggagca catgtaactt atctaggtcc aaatgattgt catatgggta
     6361 aaaaagagtc tgtatcagat acagcaaaag ttctaggaag attctatgat ggaatagaat
     6421 ttagaggctt taaacaagaa acagttgaaa gtctagcaaa atattctggt gtgcctgttt
     6481 ggaatggact tacagatgaa tatcatccaa cacaaatact ggcagatttt ttaacagtaa
     6541 ttgaaaatgt agataaagat ttgaataaag ttaaatttgt atatgttggt gatgctagaa
     6601 ataatatggg aaactcactg atgataggat gtgctaaaat gggaatacat ttcgtagcac
     6661 tagcacctaa ggaactttgg ccaaatgaag aattggttaa ggaaatgaag gaaatagcca
     6721 agaaatccaa aggagatata atgttgactg aaaatattga tgatgttaaa ggtgcagatg
     6781 ttatatatac agatgtatgg gtttctatgg gagaagagga gcaatatgaa gcaagaataa
     6841 atcaacttaa agattatcaa gtaaatatgg atatgataaa gaaaactgaa aatgaaaatg
     6901 ttatattttt acactgtctt ccagcatttc atgatttaga aactaaggtt gctcaggaga
     6961 tttatgaaaa gttcggatta tcagaattag aggttacaaa cgaggtattt aattcaaaat
     7021 attcaaaggt atttgaagaa gctgaaaata gaatgcatac aataaaagct gttatggttt
     7081 ctactatgac tgatgtaaat atgaacaata atttaatata gatatgtttt aatatagact
     7141 ttactttaat gaaaatttat aaaatatttt aaatatatta ttcaaaaact ctcattatat
     7201 gttaaaataa cttatgtatc aacaaattaa gagggaggat ttgagatatg aaaaaaatca
     7261 tattagcttt aacaactttt ttattagcaa tatctttaac agcatgttca agtgcaaaac
     7321 cagaagatac aattgatagt ttttttaaca gtgcgaaaaa gtttgacttt gaaggcatga
     7381 ataaggtaat ggaaaataat gacgaaaaat ataaggatat attaaaggaa ttagatacaa
     7441 aagacccaaa tgcccaatat gttttagatt atctaaaaca gaatgcatct aaaatcacat
     7501 atacaataaa agacagcgag gttaaaggtg ataaggctac aatcaaagta gaatgtaaat
     7561 ttatagattc aacaccatta cttcaagaaa tagtagctga ggcatttaca aagatgattg
     7621 gtatgagttt ttcaggacaa gacttaactg atgagaaaac aactgaaatg ttagtatcaa
     7681 ttatgaaaga aaaacaaaaa agcgttaaag agacttatgt tacaaaaaat gtagagtttg
     7741 aatgttctaa aaaggataat aaatggataa taagttcagt aaatgatgca gtagctgatg
     7801 tattgttatc taatcttgtt acagcaggac aagaattttc taactctatg aatacacttg
     7861 aataatattg tttaggtgta gtaaagtaat aaatatatga ttatttttat aaataaacat
     7921 ataaatattt atgaaggata ccatttttgg tatccttttt attaatataa tgaaatacat
     7981 ggttaatttc tatattgtca agaaactatg atatatgtta taagtctata ctatttaaaa
     8041 taaacttata acatatattt tttataatat agtgcatgaa aaatttattt aactaatttt
     8101 agatatttat tgacaactga ttcagccaag cattttgatg aatcaacaat atttattgaa
     8161 ggatatgatt tttctaaaac tacatttaaa tcagtacaag caattactat attttctata
     8221 gattcatttt taacatcttc gataagttta ttccaaatat caatattgtg tggattttct
     8281 ttatccattt ttatattttg aataagattg tttaatttta tttgccattc atctttaaat
     8341 ataaattcat gtccattatg tattatacca ttctggtaaa ttgtagactc aaaagttgaa
     8401 ctagtcgaaa aaagagttac tttttgtgag atagtaggta attttttaac tgtttcttct
     8461 acaatattta atattggtat attaatagac tcttttaatt ctttaaagta tatatgtgct
     8521 gaattgcatg gcattgcaat aaaatttaca ccagttgatt caagcttttg taatccatca
     8581 attatagttt ctttcataag ttcatgattt attggacggt caatataaaa tggggtaggt
     8641 aatgaatata tcatcatctt tggaaattca tcatcatatt ttgctccata ttgagattga
     8701 cactcatcaa taattaaatc aacaaaaggg gctgttgacc ttggacccat tccagccaaa
     8761 ataccaatta atttttcatt cataaaaatt atctccttta tatataaata tatttatgta
     8821 taaaataaaa atctataaaa gcataaaatt atattttata atagattata ttgtacactt
     8881 atataatata aatataaagt gattttttag attatatatt ttaatatact ttcttatata
     8941 agaattattt taaatcaaga ttatctagta tttttaaaaa tatttttaca gcagtatcca
     9001 agtcatctac agaaacactt tcattaggat tatgacttac gcccccagcg catcttataa
     9061 ataccatacc aatatcagtt atattatcca tttcctgagc atcatggcca gcaccactat
     9121 aaatataaaa aggattaaga tttaaatcta taaaactttt ttctatgatt tttgttattt
     9181 tattagaaca tggtacagga acattttcaa aagcaagttc acttgtataa ttaagttttc
     9241 tattttcaca tatatgtgat atttcattaa atatcttttc tacagaatta tcaagaattt
     9301 cttgtgaaca agagcgtaca tcaagagtaa attcagctct ttcaggtacc acatttgatg
     9361 aagatggata gaaattcatc tttcctacag tagcaaccaa atcagcagtc gttttagcta
     9421 ctttttcgat agctaataca cattcacagg cacaacatcc agcatcaagt ctcatattca
     9481 ttggaagtgt accagcatgt ccagacttac catttactga tatcttaaaa cttttaaatc
     9541 ctgtaatact tgatacaatt ccagcaggaa gagattcatt ttctaaaaca ggaccctgct
     9601 caatatgaaa ttctaaatat gcatctacat cttttctagg atgcaaattt gttaagtttt
     9661 ttgtattaaa tccaaacttt gttacagctt cttcaagtgt aattccattt tcatcaacag
     9721 atttaagaag ttcctcttta aaagtaccag caaaaacttt acttcccatt aaagaagttt
     9781 caaatctagt tccttcctct tcagcgaaag caattagctt aatattgaaa ggataagacc
     9841 tattattgtg ttttgcttct tcaagaccaa ctagaggcac tattatacct aacataccat
     9901 caaatatacc tccacacttt acactatctt gatgagatgc aactactaat gtgggagcat
     9961 ttggaaagct tgatttatat gtacctataa cgtttccaat gtcatcaatt tcaatatcaa
    10021 gatttaaacc ttccatccat gaactaatta aatcaataga ttttttatgt tcttgagtca
    10081 agataagtct tgtaagacca tttgttgttg aacttatttt tcctaatgtt tgtagataat
    10141 ccatacattt ttttcctaac atatttacct cctaaaaata taatttttat ttaagctaag
    10201 attagctttt atacttataa tttttgaact ttcaaataat tttgtatgta tagtaaaata
    10261 ctattttagt attaataatg atataaaaat ataaagtctg tagacgaaga gcagaagttt
    10321 taagttaaaa atataaaata tgatttttat tattatagta tttttctaaa ataatatctc
    10381 tttccagtta gaggataatt ttcaagtgaa aatactttat ggtatccaaa tttctcataa
    10441 aatttaggtg cttgaaaact gaatgtatct aaaaaaacat atttacaacc tcgttcttta
    10501 gcaatttttt cagccttata taaaagttga cttccagtac ctttatatct aagcttctca
    10561 ctaacccata agtattttat agaaagccaa ttaccatgag taacacctat aaaacctgca
    10621 acaattttac ctgctttatc tcgaatatat attcctaaat ccactgggtt tttatcttca
    10681 agtctagcaa gattatattt taataatcct tgaaaaatag tatcttcatc ttgtttttct
    10741 attttttctg taatttctaa ttccatattt gaactttctc cttgtataat cttttgtata
    10801 ttggtatttt ttaataaaat cagtagaaag aatatagttt aacattattc taataggcat
    10861 ttatgctaat gtcaaactaa taatacttat tcttaatttt atattgttga tattaaattt
    10921 ttttaaataa aaatgtagtt taagttatat aaaaagaaat catcaataaa tttagtaaac
    10981 ctaaattgtt gaatattaaa ataagttaat ttaatacata aaaactattt taga
//
LOCUS       DAEPID010000107        10889 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.108, whole genome shotgun sequence.
ACCESSION   DAEPID010000107 DAEPID010000000
VERSION     DAEPID010000107.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 10889)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 10889)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..10889
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.108"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            240..1361
                     /locus_tag="KR257_003380"
     CDS             240..1361
                     /locus_tag="KR257_003380"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428389.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0032045.1"
                     /translation="MRVEAPIKVDRKTKKLAKRVESGEIAVINHIDIDEVAANSLVEA
                     KIKLVINAAPSISGRYPNKGPGILTENNILIIDNVGEELFEELKEGETIEVVDGKIYR
                     KGKFLGAGEVLDKYEVSHQIKAAYENLAVELDRFIDNTIDYAKKEKGFILGEVEIPKV
                     KTNYANKHVLIVVRGQDYKEDLSTMLSYIEEVKPVLVGVDGGADALIEFGYTPDVIVG
                     DMDSVSDEALKKASEIVVHAYTDGRAPGLKRVEELGLDAVVFPAPGTSEDIAMLIAYE
                     YKAELIVAVGTHSNMIDFLEKGRKGMASTFLVRLKIGSKLIDAKGVNLLYRSKLKIKY
                     IWALIATALFPVLVVASLSPGVQQFIQLMQLKFRVLLQM"
     gene            1379..2254
                     /locus_tag="KR257_003381"
     CDS             1379..2254
                     /locus_tag="KR257_003381"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888966.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="copper transporter"
                     /protein_id="HBH0032046.1"
                     /translation="MHINMKYYIVTIGAIFIALGIGMLVGFNLNNNQQLSEQQANIIN
                     DLDDKFDILKEKNDKLDSDLASVNRDYEEAVNFINKNVDKILAGSLNGKSIGIISANE
                     NDDYTKNIEDIINKSNGSIAFNIILKENITNPEKLKEMSTKLGTDVKNANDAVNYIID
                     TLKKEDASDILTYLQELDVIKFNFIGDTYLKYDSVVIAGGNDAKDSTKQFEKIEKFVV
                     SKLKSENKYLVEVQNTGVKTSYVELYSKNKVATIDNIDEGIGSISLAILLQQGNIVGN
                     FGRLDTATSLLPSIK"
     gene            2278..2970
                     /locus_tag="KR257_003382"
     CDS             2278..2970
                     /locus_tag="KR257_003382"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428385.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase family 2 protein"
                     /protein_id="HBH0032047.1"
                     /translation="MDSYISIIIPAYNEESRIKYTLESILDIKQINEIIVVDDGSIDN
                     TAKVVSELENEKIKFFKLDKNRGKGYALNYGIKLAMKNADIIGFLDGDLGSSAKEVEK
                     LIVPILNGEADVTIAKFPPAKRKGGLGFVKGLAKNSVFEMTGVELDATLSGQRIFKRE
                     VLEKFDEIPFGYGVEVGMTIDILKYGFKIKEVLVNMTHNETGRNLKGFIHRGKQYYHI
                     KKVLGQKKKEWR"
     gene            2978..3802
                     /locus_tag="KR257_003383"
     CDS             2978..3802
                     /locus_tag="KR257_003383"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428383.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyl transferase"
                     /protein_id="HBH0032048.1"
                     /translation="MKDYILYTILLLTGLFGTYAVIPLFKNLLINGNVLRPNYKKDMI
                     PVSMGIVFLPMIVINGIILAFFTTEFKDLAYIFMFMFGMISMFFAGILDDVIGNRDVS
                     GLKGHFKSLFKGSLTTGGFKALFGGFVGLIVSVAISKDIIDIIVNTLIIALSTNLMNL
                     LDLRPGRAIKAYLFIMVIIFLTLTGFVQVLPLLIVPNVLAYFNYDLKARAMMGDTGSN
                     VLGISIGMLISFGYPFNIRLGWLIFVVIMHIFTEKYSLTKIIEKNKLLNFIDKLGR"
     gene            3807..4874
                     /locus_tag="KR257_003384"
     CDS             3807..4874
                     /locus_tag="KR257_003384"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896132.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3866 family protein"
                     /protein_id="HBH0032049.1"
                     /translation="MISKRVGIVESIVSQTETLDDIRVNINGEIQRAYNYPKISGTIN
                     IGDEVVLNTTAVELSLGTGGYHFVITNLNNIESTLTEGGHIMKLRYTPLQIKVDSVEE
                     QESIYHDKFANFKGLEGLSVVVGTLHSMLTPFAASFKRNNPNKKLVYIMTDGASLPIY
                     LSKNVDTLKEKKLIDSTITIGNAFGGDYECINIYTALITAKEILKADAVFVSMGPGIA
                     GTGTKYGFTGIEQGSILDAVKKLEGRAIAIPRISFADKRERHQGISHHSMTVFKEIVN
                     VNVDIPITIYDDEKLNFIKEQINLNGLDKKHNIIYIDNNKTKEDLDYFNLKVKSMGRN
                     YEQDEAFFKAASTAAYYLMEV"
     gene            4876..5412
                     /locus_tag="KR257_003385"
     CDS             4876..5412
                     /locus_tag="KR257_003385"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419216.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NUDIX hydrolase"
                     /protein_id="HBH0032050.1"
                     /translation="MVLEEKTISSDRVYTGKVITLKVDTVEIPGQGYQKRELVEVGGA
                     VGIVAITDDNKVVLVKQFRKPIEKPIFEIPAGKLEKNESPKECAERELKEETGYSAKN
                     IKLIHKFFTSAGFSNEIMFVYLATGLTPGENNLDADEFLDVYEIELEEAYNMVLKNDV
                     EDAKTSIGLLLVKDMFKN"
     gene            5480..6085
                     /locus_tag="KR257_003386"
     CDS             5480..6085
                     /locus_tag="KR257_003386"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888973.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="stage II sporulation protein M"
                     /protein_id="HBH0032051.1"
                     /translation="MRRTYRKNDFRELNRQIIIIGLLFMMSIVVGSYINKILPGSSNN
                     ILNNINPAVEYYNLNISIKDTVIQNLKSDAIFMGSIALLSLFVVTIPAVLVAFVLKGM
                     SIGYTINSCILALKFKSIKMILIILFKNLIIIPCAIILALISLSYFKEMVYEFKKKNR
                     KNMQFLIKRYILNIIIIIALSLGLQLILNTASIGIIKFLAK"
     gene            6097..7011
                     /locus_tag="KR257_003387"
     CDS             6097..7011
                     /locus_tag="KR257_003387"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896134.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tyrosine-type recombinase/integrase"
                     /protein_id="HBH0032052.1"
                     /translation="MDIIEGYIDYIKDKKKLSENTVASYFMDIKKYMEYINQKSIKLV
                     DIVENDIISYLIKLEKDNVSIATIARMISSIKSFHDYLFLNHICTNNPAKDIKKPKIK
                     KENINILTEEEIERLLNFPKLTTPKLIRDKAIFEVLYGTGIKVSELVEMNIEDIDLDI
                     DYIYCNSCCKNQRVIPLCDITKLYLEKYLKEARPKMAVEGEKSLFVSSLGQRFTRQGL
                     WKVIKKYSNLANIDKNINPTMLRHSFAIHLLNEGANIAVVSKILGNVNLSSLQVYLNH
                     IDKNVRREIKEKHPRNDVDVELQKAEAK"
     gene            7053..8225
                     /locus_tag="KR257_003388"
     CDS             7053..8225
                     /locus_tag="KR257_003388"
                     /EC_number="5.4.2.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428374.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphopentomutase"
                     /protein_id="HBH0032053.1"
                     /translation="MSRVIWIVIDSVGIGALPDAEKFGDSKDVSTLGNIFKEYPDIQI
                     PNMRNLGIGNIDGIDFFESIKEPIGCFGKCKEMSQGKDTTTGHWEMTGIIVDKPFKTF
                     EHGFSKEIIEEFEKKTGRKVVGNKPASGTVIIDEYGEHQIKTGDVIVYTSADSVFQIA
                     ANEEVIPLEELYNMCKIAREIMMGDNAVARVIARPFIGKKKGEFVRTSNRRDYSLDPF
                     EPTVLDNIKESGLDVLAVGKIEDIFNGKGITDAIHTKSNMDGVDETLNYMKQDNKGLI
                     YSNLVDFDSKYGHRRDPEGYKKALEEFDSRLPEIMANMREDDILIINADHGNDPTYKG
                     TDHTREYIPVMIYGNKIKKGFNLGVKDTFADIGATVADILNVKLPKHGSSFKEDLF"
     gene            8272..9084
                     /locus_tag="KR257_003389"
     CDS             8272..9084
                     /locus_tag="KR257_003389"
                     /EC_number="2.4.2.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888977.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="purine-nucleoside phosphorylase"
                     /protein_id="HBH0032054.1"
                     /translation="MFEKIAQSSKFINSKSDIKPKIGLILGSGLGDLANDIEDPVAIK
                     YSEIPNFPVSTVAGHAGQLVIGKLEGKEVIAMQGRFHYYEGYSQKEATFPVRVMKELG
                     VEILIVTNAAGGVNKEFKAGDLMLIRDHINFSGSNPLVGKNDDRFGARFPDMSDAYSS
                     KYVDVVKNCAKECNIDVKEGVYMFFSGPNYETPAEVRMAQILGADAVGMSTVPEVIVA
                     SHSNIGVIGISCITNMAAGILNQPLSHEEVIETTQKVKSEFMNLVKTTVKNL"
     gene            9288..10613
                     /locus_tag="KR257_003390"
     CDS             9288..10613
                     /locus_tag="KR257_003390"
                     /EC_number="2.4.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892935.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pyrimidine-nucleoside phosphorylase"
                     /protein_id="HBH0032055.1"
                     /translation="MRMYDIIKKKRDNLELSKKEINYFIENYSKGDIPDYQASALLMS
                     IYLNKMNKQETVHLTEAMMNSGDMINLSEIDGIKVDKHSTGGVGDKTTIALIPLVASC
                     GAPVAKMSGRGLGHTGGTIDKLESIPGFSTEMEISKFIDSVNKSKIAVCGQSAKVAIA
                     DKKIYALRDVTATVDNISLISSSVMSKKLASGADAIVLDVKTGDGAFMKTLEESFELA
                     KSMVDIGTGMNRDTIGIVTDMDEPLGFAVGNSLEVIEAIETLKGNGPKDLVELCEVLG
                     AYMLVLSKVAHDFEDGVEKIRESIKSGTAIQKLKEFIENQGGNKDVVDDYSLFKKSKY
                     KYPVKSTKSGYISKIKAEDVGVSAMILGAGRETKDDILDLSAGIILEKKVGDYVNEGE
                     VLAYMYYNDEQKLSLAKGRFIDSYSIVDSKIEKNKLIYGIVTKEEIKKF"
BASE COUNT         4361 a         1058 c         2049 g         3421 t
ORIGIN      
        1 tatagtatgt gtctttacaa gttgtaaact gacagtggtt tattttttaa tataaatatt
       61 gactttgatg caggtaaact ttgtattttt aagcgtatta tggaatatgt taaataaaaa
      121 aatgatgaaa tatagtattg taaatgccaa agatgcaaaa caaacttaaa acatttattt
      181 tattgttaag taatgctata atataatgtg attttaataa tgatagtgga ggtttaaata
      241 tgagagtcga ggcccctata aaagtagatc gaaaaaccaa aaaacttgct aaaagagttg
      301 aaagtgggga aatagcagtt ataaatcata tagacataga tgaagttgct gcaaactctt
      361 tagtagaagc taaaataaaa cttgtcataa atgcggctcc ttctataagt ggtaggtatc
      421 ccaataaagg tccagggata ttaactgaaa ataatatact aataattgat aatgttggag
      481 aagagttatt tgaagaatta aaagaaggag aaactataga agttgtagat ggaaagatat
      541 atagaaaagg aaaattttta ggtgcaggag aagttttaga caagtatgag gtttcacacc
      601 aaataaaggc tgcctatgag aatttagctg tagaattgga tagatttata gataatacta
      661 tagattatgc taaaaaagaa aaaggattta tacttggaga agtagaaatt ccaaaagtga
      721 aaactaatta tgctaataaa catgtattga tagttgtaag aggtcaggac tacaaagaag
      781 atttaagtac tatgctttct tatatagaag aggtaaagcc agtattggtt ggtgttgatg
      841 gaggagcaga cgctttaatt gagtttggat atactccaga tgtgattgta ggtgatatgg
      901 atagtgtaag tgatgaagct ttaaaaaagg ctagtgaaat agtagtacat gcttatacag
      961 atggaagagc accaggtctt aaaagggttg aggaattagg cttagatgca gttgtatttc
     1021 ctgcaccagg aactagtgaa gatatagcta tgcttatcgc ttatgagtat aaggctgagt
     1081 taatagtagc agttggtaca cattcaaata tgattgattt tcttgaaaaa ggaagaaaag
     1141 gtatggcaag tactttttta gttagactaa aaataggttc aaagcttata gatgctaaag
     1201 gcgttaattt gttatacaga agtaaattaa aaataaagta catatgggca ttaatagcaa
     1261 cagcattatt tcctgtgttg gtagttgcat cattgtcacc aggagttcaa cagttcatac
     1321 aactaatgca attaaagttt agagtattat tacagatgta aattttagga ggataaatat
     1381 gcatattaat atgaaatatt atatagtcac tataggggct atatttatag ctttgggtat
     1441 aggcatgtta gtaggattta atttaaataa taatcaacaa ttaagtgaac aacaagcaaa
     1501 cataataaat gatttggatg ataagtttga tatcttaaaa gaaaaaaatg ataaacttga
     1561 cagtgactta gcaagtgtaa atagagatta tgaagaggca gttaatttta taaataaaaa
     1621 tgtagataag attttagctg gttcgctgaa tggtaaaagt ataggaataa tatctgctaa
     1681 tgaaaatgac gattatacaa aaaatataga agacataata aataaatcta atggaagcat
     1741 tgcatttaat ataatattaa aagaaaacat aacaaatcca gaaaagttaa aggaaatgtc
     1801 aactaaacta ggtacagatg taaaaaatgc aaatgatgca gttaattata taattgacac
     1861 tcttaaaaag gaagatgcaa gtgacatttt aacatatctt caagaactag atgtaataaa
     1921 gtttaatttt attggagata catatctaaa atatgattcc gttgtaatag ctggtggaaa
     1981 tgatgcaaaa gacagtacaa aacagtttga aaaaatagaa aaatttgtag tttcaaaact
     2041 taaatcagag aataaatatt tagtagaagt tcaaaataca ggagttaaaa cttcttatgt
     2101 agaactatat tctaaaaaca aagttgcaac tatagacaat attgatgaag gtataggaag
     2161 tatatctcta gctattcttc tacaacaagg taatatagtt ggtaattttg gtagattgga
     2221 tactgcaact tcattgttgc catctattaa atagaaataa ttttaaggag agaaaaaatg
     2281 gattcttata taagtataat aataccagct tataatgaag aaagtagaat aaaatataca
     2341 ttagaaagca tattggacat taagcaaata aatgaaataa tagttgtgga tgatggttca
     2401 attgacaata ctgctaaggt tgtatctgag ctagaaaatg aaaagattaa attttttaag
     2461 ttagataaaa atagaggtaa aggatatgct ttaaattatg gtatcaaatt agcaatgaaa
     2521 aatgcagata ttataggttt tctggatgga gatttaggaa gttctgctaa agaagttgaa
     2581 aaattaatag tacctatatt aaatggtgag gcggatgtta caatagccaa gtttcctcct
     2641 gcaaagagaa aaggaggttt gggatttgta aaaggtttag ctaaaaattc tgtgtttgag
     2701 atgactggtg ttgagttaga tgcaacttta tcaggtcaaa gaatatttaa aagagaagtt
     2761 ttagaaaagt ttgatgaaat accttttgga tatggagtag aagttggaat gaccattgat
     2821 atattaaagt atggatttaa aattaaagaa gtattagtaa atatgactca taatgaaaca
     2881 ggaagaaatt taaaaggttt tattcataga gggaaacagt attatcacat aaaaaaggtt
     2941 ttaggacaaa aaaagaaaga atggaggtaa tatcttagtg aaagattata tactttatac
     3001 cattttatta ttaactggat tatttggaac ctatgctgta attccactat ttaaaaattt
     3061 attgataaat ggaaatgtac ttagaccaaa ctataaaaaa gatatgatac cagtaagtat
     3121 gggaattgta tttttgccta tgattgtaat caatggaata atacttgctt tctttactac
     3181 agaatttaag gatttagcgt atatatttat gtttatgttt ggtatgatat ccatgttttt
     3241 tgcagggata ctagatgatg tcattggaaa tagagatgta agtggtttaa aggggcattt
     3301 taaaagttta tttaaaggaa gtcttacaac aggaggtttt aaagctttat ttggtggatt
     3361 tgtagggctt atagtttctg ttgctatatc aaaagacata attgatataa tagtaaatac
     3421 actaataata gctctatcaa ctaatttaat gaatcttttg gatttaagac caggaagggc
     3481 aataaaagca tatttattca taatggtaat tatattttta acattgacag gatttgttca
     3541 agttcttcca ttacttatag taccaaatgt acttgcatac tttaattatg atttaaaagc
     3601 aagggctatg atgggagata ctggttcaaa cgtccttgga atatctattg gaatgctcat
     3661 ttcttttggg tatccattta acattagatt aggatggtta atatttgtag ttattatgca
     3721 tatattcact gagaaatact cattaactaa gataatagaa aaaaataaac tattaaattt
     3781 tatagataaa ttgggaaggt agtattatga taagcaaaag agtggggatt gttgaatcaa
     3841 tagtaagtca aactgaaaca ctagatgata taagagtaaa tataaatgga gaaatacaaa
     3901 gggcatataa ttatcccaaa atatctggaa ctataaatat aggtgacgaa gtggttttaa
     3961 atacaacagc agtagaactg agcttaggta caggtggata ccattttgta ataactaatt
     4021 taaataatat agaatctact ttaactgaag gtggacatat aatgaaactt agatatacgc
     4081 ctcttcaaat aaaagtggat tctgttgagg aacaagaaag tatttatcat gataaatttg
     4141 cgaattttaa aggattagaa ggtctttctg ttgtagtagg gactcttcat agtatgttaa
     4201 ctccatttgc agcttcattt aaaagaaata atccaaataa aaaattagtg tatataatga
     4261 ctgatggagc atctcttcca atttatttaa gtaaaaatgt ggatacttta aaagaaaaaa
     4321 aattaataga tagtacaata actataggaa atgcgtttgg tggagattat gaatgtataa
     4381 atatatatac tgcattaatt acagcaaaag aaatactaaa agcggatgca gtatttgtca
     4441 gtatgggacc tggaattgct gggacaggaa caaaatatgg atttacaggg attgaacaag
     4501 gctctattct tgatgctgta aaaaaacttg aaggaagagc aattgcaatt ccaagaatta
     4561 gttttgctga caaacgagaa agacatcaag gtatttcaca tcatagtatg actgtattta
     4621 aagaaattgt aaatgtaaat gtagacatac caataactat atatgatgat gaaaaattga
     4681 actttataaa agagcaaatc aatttaaatg gtttagacaa aaagcataat ataatttata
     4741 tagataataa taaaacgaaa gaggatttag actattttaa tctaaaagta aagagtatgg
     4801 gaagaaatta tgaacaagat gaggcatttt tcaaagctgc aagcacagca gcatattact
     4861 taatggaggt ttaagatggt attagaagaa aaaactatta gtagtgatag ggtttataca
     4921 ggtaaagtaa ttactttaaa ggttgatact gttgaaattc cagggcaagg atatcaaaaa
     4981 agggagttag tagaagttgg tggagcagta ggaatagttg caatcacaga tgataataaa
     5041 gttgtgttag ttaagcaatt tagaaaacct atagaaaagc caatctttga aattccagct
     5101 ggtaaactag aaaaaaatga aagtccaaaa gaatgtgctg aaagagaatt aaaagaagaa
     5161 acagggtata gtgcaaaaaa tattaagcta atacataaat ttttcacttc agcaggtttt
     5221 tctaatgaga taatgtttgt atatttagca acaggtctta ctccaggaga gaataattta
     5281 gatgcagatg agtttttaga tgtctatgaa attgagcttg aagaagcata taacatggta
     5341 ttaaaaaatg acgttgaaga tgcaaaaaca tctattggat tattattagt aaaagatatg
     5401 tttaaaaatt aatatttata aaatgaataa ccctttgtcc taaagcatat tattttataa
     5461 aggacaaggg ggaattaaat tgagaagaac atatagaaaa aatgatttta gagaattaaa
     5521 tagacaaata attattatag gattgttgtt tatgatgtct attgttgttg ggtcttacat
     5581 aaataaaata ttgccaggtt ctagtaacaa tatattaaac aatataaatc ctgctgtaga
     5641 gtattataat ctaaatataa gcataaaaga tacagtgata caaaatttaa aatcagatgc
     5701 aatctttatg ggctcaatag ctctattaag tctatttgta gtaacaattc cagcagtgtt
     5761 ggtagctttt gtattaaaag ggatgtcaat tggttataca ataaatagtt gtatattggc
     5821 attaaaattt aaaagtataa aaatgatttt aataatatta tttaaaaatt tgattattat
     5881 tccatgtgca atcatattag cattaattag tttaagttat tttaaagaaa tggtttatga
     5941 atttaaaaag aaaaatagaa aaaatatgca atttttaatt aagaggtata tactaaatat
     6001 tataattata atagcactat cattggggtt gcaattaata ttaaatactg caagtattgg
     6061 tattattaag ttcctagcta aataaaggag tttataatgg atattataga gggatatata
     6121 gattacataa aagataaaaa aaaattatca gagaatacag tggcatcata ctttatggat
     6181 ataaaaaaat atatggaata tataaatcaa aaaagcatta aactagtaga tatagtagaa
     6241 aatgatatta taagttactt aataaagttg gaaaaagata atgtatcaat agctacaata
     6301 gcgaggatga tatcctctat aaaatctttt catgattatt tatttttaaa tcatatatgt
     6361 acaaataatc ctgcaaagga tataaaaaaa cctaaaataa aaaaagaaaa tataaatata
     6421 cttacagaag aagaaattga aagactatta aattttccaa agttaacaac acctaaattg
     6481 attagggaca aggctatttt tgaagtatta tatggtactg gtataaaagt atctgaatta
     6541 gtagagatga atatagagga tattgaccta gatattgatt atatatattg taattcatgt
     6601 tgtaaaaatc aaagagtgat accactttgt gatattacaa aactttactt agaaaagtat
     6661 ctaaaagaag caagacctaa aatggctgta gaaggtgaaa aatcattatt cgtaagttca
     6721 ttaggtcaaa ggtttacacg acaaggtctt tggaaagtca taaaaaaata ttctaatcta
     6781 gccaatatag ataaaaatat aaatcctaca atgcttagac attcatttgc tattcatttg
     6841 ttaaatgaag gtgctaacat tgctgttgta agtaaaattt taggaaatgt taatttatct
     6901 agtttgcaag tatatttaaa tcatatagat aaaaacgtga gaagagaaat aaaggagaaa
     6961 catcctagaa atgatgttga tgtagaatta caaaaagcag aagctaaata gactatatag
     7021 caaattttat aatttagaag gagcatattt atatgagcag agtaatttgg attgtaattg
     7081 atagtgttgg gataggagca ttgcctgatg ctgaaaaatt tggtgatagt aaggatgtaa
     7141 gtacccttgg aaatatattt aaggaatatc cagatattca gattcctaat atgagaaatt
     7201 taggtatagg aaacatagat ggtatagatt tttttgaaag tataaaagaa ccaataggtt
     7261 gttttggaaa gtgtaaggaa atgtctcagg gaaaagatac tactacaggt cattgggaaa
     7321 tgactggtat aatagttgac aaaccattta agacatttga acatggattc tctaaggaga
     7381 taatagaaga gtttgagaaa aaaactggaa gaaaagtagt aggaaataaa ccagcttcag
     7441 gaactgtaat aatagatgag tatggagaac atcaaataaa aactggagat gtaatagtat
     7501 atacatcagc tgatagtgta tttcagattg ctgctaatga agaagtaatt cccctagaag
     7561 aactctataa tatgtgcaaa atcgctaggg aaataatgat gggggataat gcagtagcta
     7621 gagtaattgc tagaccattc ataggtaaga aaaaaggtga gtttgtgagg acttcaaata
     7681 gaagagatta ttcactagac ccatttgaac caacagttct tgataatata aaagaatcag
     7741 gacttgatgt tttagcagtt ggaaaaatag aagatatttt taatggaaaa ggaattacag
     7801 atgctatcca cactaaaagc aatatggatg gagtggatga aactttaaat tatatgaaac
     7861 aagataataa aggtctaata tattcaaatc tcgttgattt tgattctaaa tatggtcata
     7921 ggagagaccc agaaggatat aagaaagctc ttgaagagtt tgatagtaga cttcctgaaa
     7981 taatggctaa tatgagagaa gatgatattt taataatcaa tgcagaccat ggaaatgacc
     8041 caacatataa aggtacagac catacaagag aatatatacc tgttatgatt tatggcaata
     8101 agattaaaaa aggttttaat ttaggagtaa aagatacttt tgctgatatt ggagcaactg
     8161 ttgcagatat actaaatgta aagttgccta aacatgggtc aagctttaaa gaagatttat
     8221 tttaaactat aaaatgataa aaacttagct taataggatg gagagattgg aatgtttgaa
     8281 aagatagcac aaagtagtaa atttataaat tctaaaagtg atataaaacc taagattggt
     8341 ttgatattag gttctggact aggtgattta gcaaatgata tagaagaccc tgtcgcaatt
     8401 aaatatagtg aaattccaaa cttccctgta tcaacagtag caggacatgc tggacaactt
     8461 gtaattggaa aacttgaagg aaaagaagtt attgctatgc aaggtagatt tcattactat
     8521 gaaggatatt ctcagaaaga agctactttt ccagtaaggg ttatgaaaga attaggagtc
     8581 gagattctta tagtaactaa cgctgctgga ggcgtaaata aagaatttaa agcaggagat
     8641 ttgatgctta taagagacca tataaacttt agtggaagta atccattagt aggaaaaaat
     8701 gatgacagat ttggtgctag atttccagat atgtcagatg catattcttc taaatatgta
     8761 gatgtagtta aaaactgcgc taaagaatgc aatatagatg tcaaagaagg cgtttatatg
     8821 ttttttagtg gtccaaacta tgaaacacca gcagaagtga gaatggcaca aattttggga
     8881 gctgatgctg taggtatgtc tactgttcca gaagtcatag tagcttctca ctctaatata
     8941 ggagttattg gtatatcttg tataacaaat atggctgctg gcatcttaaa tcaaccacta
     9001 agtcatgagg aagtaataga aactactcaa aaagttaaat cagaatttat gaatttagtt
     9061 aaaacaacgg ttaaaaattt ataagttaaa gcttattata gattttttga ggaagtttat
     9121 aataaaatag ttaatgttta atttgaaaag aattaataaa aagctgtctt gatatagaaa
     9181 gttatttcta ataaaggaca gtttttttat aatactacaa catttgaaag tgttttaaag
     9241 tttaatattt atttaaatta ttataggtta gaatggagat ttcaattatg agaatgtatg
     9301 atattataaa aaaaaagaga gataacctag agcttagtaa aaaagagata aactacttta
     9361 tagaaaacta ttcaaaggga gatatacctg actatcaagc ttctgcacta ttaatgtcga
     9421 tttatttaaa taagatgaat aaacaggaaa ctgtacatct tacagaagca atgatgaact
     9481 ctggagacat gataaaccta tctgagatag atggaataaa ggtagataag catagtactg
     9541 gtggtgttgg agataagact accatagctc ttataccttt ggttgcttca tgtggagcac
     9601 cagttgcaaa gatgtcaggt agaggtcttg gtcatactgg tggtactatt gataaattgg
     9661 agtctatacc aggtttttcg acagaaatgg agataagtaa atttattgat tctgtaaata
     9721 agtctaaaat agcagtttgt ggtcaaagtg caaaggtagc aattgcagat aagaaaatat
     9781 atgctcttag agatgttaca gcaactgttg ataatatatc attgatatca tcaagtgtaa
     9841 tgtctaagaa gttagcttca ggagctgatg caattgtgct agatgtaaaa actggtgatg
     9901 gagcatttat gaagacatta gaagagtctt ttgagttagc taaatctatg gttgatatag
     9961 gtactggtat gaatagagat acaataggga ttgtaacaga tatggatgaa cctttaggtt
    10021 ttgcagtggg aaactcttta gaagttatag aagcaattga gacattaaaa ggaaatggac
    10081 ctaaagacct tgttgagcta tgcgaagtat taggagcata tatgttggtt ttatcaaagg
    10141 tagcacatga ttttgaagat ggtgttgaaa aaataagaga atcaataaaa tctggtactg
    10201 ctatacaaaa actcaaagag tttatagaga atcaaggtgg taataaagat gtagtagatg
    10261 attattcttt attcaaaaaa tcaaagtata aatatccagt taaatcaact aaatcaggtt
    10321 atataagcaa aattaaagct gaagatgttg gtgtatcggc tatgattctt ggagcaggta
    10381 gagaaactaa agatgatatt ttagatttat cagcagggat aattttagaa aagaaagtag
    10441 gagattatgt aaatgaaggt gaagttttag cttacatgta ttataatgat gaacaaaagc
    10501 tttcattggc aaagggaaga tttattgatt cctactctat tgtagattca aaaatagaaa
    10561 aaaataaatt aatatatggt attgtaacta aagaagagat taaaaagttt tagaaaattt
    10621 tagaaaagtg attataaaag gcctaacatg tcaaaaataa tgttaggttt tttatttttt
    10681 gatagactat aaattatacc aaaaatatat attttaaaac attttttaca atataaataa
    10741 gtttattcta caagatgatt gaaaattaaa gtatctagtt ttataataga aaatggataa
    10801 atatacataa ggagtagatt atattatgaa ctttaaagaa aatagattga aaatagcagt
    10861 attaataatt gttattttga ttatcttag
//
LOCUS       DAEPID010000108        10076 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.109, whole genome shotgun sequence.
ACCESSION   DAEPID010000108 DAEPID010000000
VERSION     DAEPID010000108.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 10076)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 10076)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..10076
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.109"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            <1..773
                     /locus_tag="KR257_003391"
     CDS             <1..773
                     /locus_tag="KR257_003391"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428307.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=3
                     /transl_table=11
                     /product="sensor histidine kinase"
                     /protein_id="HBH0032056.1"
                     /translation="LLIITVLSIYIENENLSKLYSQNLYDKLRISKDELKKVNADLET
                     YASSIEELAILKERNRISREIHDSVGHSLSTTIIQLNAIEKLLKDKPLIYDLVHELRE
                     FVTESFQDVRRAISELKPVEYENYQSLFKIKELVKSFIKLTNINVKLTISKNTWNLSR
                     NQSITLYRLIQESLSNSSRHGKATEIRIFITFNTSNLIITISDNGIGCGNIKKGNGLN
                     SINERIYELNGKVEFDNSNNGFTIRASFPKFSGGDFFE"
     gene            766..1413
                     /locus_tag="KR257_003392"
     CDS             766..1413
                     /locus_tag="KR257_003392"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009905386.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HBH0032057.1"
                     /translation="MNKIKVLIVDDEKLIRKGLKIILSSYNDLEIVGDASNGYEALEF
                     CKMNDVDIVLMDIRMKVCDGVLGTRLIKEYNNSITLLILTTFNDDEYIKDAMKFGASG
                     YLLKDSSDEVLHEGIRSSFFGNIVLDKSVAEKIMTSEKTVKQEHLYDMYNLTEKEISI
                     IRLIANGLNNKEISQELFLSEGTIKNNITNILAKLELRDRTQLAIFAFKNKIVIE"
     gene            1542..2477
                     /locus_tag="KR257_003393"
     CDS             1542..2477
                     /locus_tag="KR257_003393"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729545.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBH0032058.1"
                     /translation="MDIVRVNNITKRFNDKLVLDNISFSVKKGEIFGLIGPNGAGKST
                     LINIITNLMLPNSGSIQINGLDLSKDYIKAKSIIGLVPQELAIIETLTPFDNLEYFGA
                     FYGLKGKLLKERIIEALEVTGLTEVKKKKVKKLSGGMQRRLNIGIALLNHPKILILDE
                     PTVGVDPQSRNHIFNFIKDISKKHETTVIYTSHYMEEVEHLCSKIFIMDEGKEIAFGD
                     NDYLKSLVSTNTKLIIEIKNINAQLIFDLKNTKGVISVLENNSLLELDIDKKLQLTDI
                     LSVIDKNNSKIMKISYEEPSLEDVFLNLTGKNLRD"
     gene            2491..3588
                     /locus_tag="KR257_003394"
     CDS             2491..3588
                     /locus_tag="KR257_003394"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896177.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBH0032059.1"
                     /translation="MKLYMSVKTMLKSLKSSFILNLIYFLALPLILSWFLGMVTESMF
                     QNPIKTESTPIVIYDKDNTRLSNDLTKYLKNDLSYILTVKKDDSKAELKLTIPKGYES
                     SLLNEKSNTLNIEKLGTRDDIAILLQDILDTYHEKFYLNNSQKISSEDFSKLFNKNSI
                     DTSIINNNVKQNSYEYFALVSLGFLVIIFIMNNILSNYISESKGLSKRLYSMPITRVQ
                     FLIYDFVGLWIYSFIFLLLYVLFFRILGITFKGNFAILLLLCALSSYFMTSISTFVTS
                     FFSKKYGTAIVYALLFLQTIFGGIFSMISDTFTKLTSLSPTYLIGELFSNYETFKTID
                     SIGDLIFTCLIISTILIALAIVKEKYKWREV"
     gene            3591..4655
                     /locus_tag="KR257_003395"
     CDS             3591..4655
                     /locus_tag="KR257_003395"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018112789.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBH0032060.1"
                     /translation="MIRLTIANIKRYLKNHNLLINMVMLPIILIFSLNFFINNSGNQS
                     MYFSPVAIVSDSSGKYEHKLINSSKLKENSFRLNELDKAMNLLKNNKVSAVFVLDKNF
                     SNSIDKLQRPVVKCFKIENGGGSLWAESQIESFITKSLKLKVDKNIDDKLTKTNIIDN
                     KPDKNKGSFLVVFLICYFMYINAAHLASDLFTLKKSNVLKRLISTDNKDIKIIFSIFL
                     GLFFIQSIVYTFALLCFSIIEDFNLSLNVLMIVLANSFVSTGFVFWVARVFKNESSIS
                     LISTFYSLIGLAISISSLIPSMDKLSFMTNLSKFTPFYWTIDAIKNNGSILINIIALI
                     LIGIIFVTAGSLKLRDFAKN"
     gene            4899..5396
                     /locus_tag="KR257_003396"
     CDS             4899..5396
                     /locus_tag="KR257_003396"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419372.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CarD family transcriptional regulator"
                     /protein_id="HBH0032061.1"
                     /translation="MYKIGESVMYPKEGACSVNDIVTKKINHEMQKYYELSVIFNSNL
                     KISIPVLNADRIGIRPVMDGNDVDNFIQSINKTDGVWIFDRKERLKLYQDKFHSGDVF
                     EIVKLIKMLMIQDSSKQLCSTDKEFLNKAQKFALSELAAAQCKSYTMVLEEMKKHILN
                     SKNTN"
     gene            complement(5572..5820)
                     /locus_tag="KR257_003397"
     CDS             complement(5572..5820)
                     /locus_tag="KR257_003397"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419369.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0032062.1"
                     /translation="MSRKAYEEALVELEKFIDERKEIIKSAEDCIDKYIVDRTLPFDY
                     KDKCVEWQQELLDIAEAQVLEANELSVLLQEKKELEED"
     gene            complement(5886..6902)
                     /locus_tag="KR257_003398"
     CDS             complement(5886..6902)
                     /locus_tag="KR257_003398"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889040.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha-hydroxy-acid oxidizing protein"
                     /protein_id="HBH0032063.1"
                     /translation="MEYNELLKSARENLNGSCKVCKVCNGVACAGEVPGMGGKGSGSS
                     FIENSKSLEKVKVNMRVIHDVSNPDTSIEMFGKKMSAPIFAAPVTGTTLNMGGKINER
                     DYIEPVVAGCANSGIYAMVGDTAVDAFLMENLDVVKKYNGAGIVFIKPWDNENIIKKI
                     RLAEEAGAFAVGVDIDACGLVTLSLHGKPVLPKNVKQIKELVKSTKLPFILKGIMTVE
                     DALMAVEAGVDAIVVSNHGGRVLDCTPGACEVLPKIADAVKGKVTILADGGVRTGLDV
                     LKMIGLGADAVLIGRPFVTASFGGATDGVETYVNKLQSELSSSMILTGCQTIKDIDGK
                     VIYK"
     gene            complement(6960..7727)
                     /locus_tag="KR257_003399"
     CDS             complement(6960..7727)
                     /locus_tag="KR257_003399"
                     /EC_number="3.1.26.4"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729543.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribonuclease HII"
                     /protein_id="HBH0032064.1"
                     /translation="MQDKSVREIKEIIETLEVEKYMEYIELLRVDERKSVQGLAIKLA
                     KKLDNIRKEEERLETINIFENEGYDKGYLYIGGIDEAGRGPLAGPVVASVVVFKKDTK
                     IEGVNDSKKLSEAKRDELFEVIKEEALDYGIGIVNNEEIDEFNILNATYMAMKKAINC
                     LKKAPDYLLVDAATIPGIDISQNPIVKGDSKSISIAAASILAKVTRDSIMYQYDRVYP
                     EYGFKSHKGYGTKEHYEAIEKYGITPIHRKSFLKNIL"
     gene            complement(7795..9984)
                     /locus_tag="KR257_003400"
     CDS             complement(7795..9984)
                     /locus_tag="KR257_003400"
                     /EC_number="1.17.4.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428321.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="adenosylcobalamin-dependent
                     ribonucleoside-diphosphate reductase"
                     /protein_id="HBH0032065.1"
                     /translation="MKYIIKRDGTKELFSKSKIEDAVYKASINSEGGVDRELAYDISR
                     KIANDYNSMEKCLSVEEIQDIVEVLLMESNRKDIAKHYILYRERRSEIRTKAWEFDEL
                     QKSIWKNKYRHNGESFDEWIKRISNNSSRISKLIRQKRFLFAGRILANRGLQKEGKKV
                     TYSNCYVIEPPKDSIEDIFDTAKKLARTFSYGGGVGIDISKLRPKGAKVNNAAKHTTG
                     AVSFMELYSMTTGLIGQRGRRGALMISMDVNHPEIEDFIDIKTDLEKVTKANISVRVT
                     DEFMQAVREKKLYNCTFEVETTGEKIVKIVNAYDLFNKFVKNNWDYAEPGILFWDKIK
                     TYNFMSEDKNFCFSGVNPCAEEPLPSGGSCLLGSINLSEFIIQPFGEHATFDINKLKS
                     CVREAVVALNDVLDEGLNLHPLQEQRDSVHKYRQIGLGVMGIADMLIKMGIRYGSDES
                     LELCDLIGKTMLNEAVKQSALIAKEYGTFSEYKYENISKSKFFIENLNEDTKEMVKKY
                     GLRNSQLLTIPPTGSISTMIGISGGIEPIFNLSYIRKTESLHDEDVYYKVYTPIVKEY
                     MDKKGITDEECLPDFFVTAMNIGYEERINMQKVWQKYIDASISSTINIPFETTVEDVF
                     NIYIKAWEAGLKGVTIFRDGCKRSGILINEKKEENNKEDKKENSKKEYYKNNKKEKDN
                     KDEKAKEIINKNFEEDEKFVCPECGSEGIAHTGGCSICLKCGYSGCN"
BASE COUNT         3504 a         1552 c         1170 g         3850 t
ORIGIN      
        1 tattgctaat tataactgta ctttctatat atatagaaaa tgagaattta tcaaaattat
       61 acagtcaaaa tctttatgat aagcttagaa tttctaaaga tgaattaaaa aaagttaatg
      121 ctgatttgga aacttatgca agttctatag aagaattagc aattttaaaa gaaagaaatc
      181 gaatatcaag agaaatacat gatagtgtag gacattctct ttctacaaca ataatacaat
      241 taaatgctat agaaaaactc ttaaaagaca aacctctaat ttatgactta gtacatgaac
      301 ttagagaatt tgtaactgaa agttttcaag atgtaagaag ggctatatct gagttaaaac
      361 ctgttgaata tgaaaattac caaagtttat ttaaaatcaa agaattagtt aaaagcttta
      421 ttaagcttac aaatattaat gttaaattaa ctatttcaaa aaatacttgg aacttatcca
      481 gaaatcaatc tataacttta tatagactta tacaggaatc cctttccaac tcatctaggc
      541 atggaaaggc aactgaaatc agaattttta ttacattcaa tacttcaaat cttataatta
      601 ctattagtga taatggtata ggatgtggca atataaaaaa aggaaatgga cttaatagta
      661 tcaatgagag aatatatgaa ttaaatggta aagttgaatt tgataattct aataatggtt
      721 tcacaattag agcttctttt cctaaatttt cagggggtga tttttttgaa taaaattaaa
      781 gttcttatag tagatgacga aaaattaatt agaaaaggtc ttaaaattat attatcatct
      841 tataatgatt tagaaattgt aggagatgct tctaatggat atgaagcttt agaattttgt
      901 aaaatgaatg atgtagacat agttcttatg gatatacgaa tgaaagtatg tgatggggtt
      961 ctaggtacaa ggcttataaa ggaatataat aattctataa cattattaat tttaacaact
     1021 tttaatgatg atgaatatat aaaagatgct atgaagtttg gtgcttcagg atacctttta
     1081 aaagatagct ctgatgaagt attgcatgaa gggattcgtt cttcattttt tggcaatatt
     1141 gtgcttgata aaagtgtagc tgaaaaaatc atgacctctg aaaaaacggt taaacaagag
     1201 catctttatg acatgtacaa tttaacagaa aaagaaatat ctataattag actaattgca
     1261 aatggactta ataataaaga aataagtcaa gaactattct tatctgaagg tacaataaag
     1321 aataatataa ctaatatttt agctaaacta gaacttcgtg acagaactca actagcaatc
     1381 tttgctttca aaaataaaat tgtaatagaa taaatctaaa aatataaagt gacttaagtc
     1441 acttttttta gtgacttata gtaatagaat tataattcac aattctttat tataatatta
     1501 tagcttttta acttatacaa aattattttg gagggattac tatggatata gtcagagtaa
     1561 ataatataac aaaaagattt aatgataaat tagtacttga taacatcagc ttttctgtta
     1621 aaaaaggtga gatatttgga cttattggcc caaatggtgc aggtaaatct acacttataa
     1681 atataattac aaatcttatg ttaccaaata gtggtagtat tcaaatcaat ggtttagatt
     1741 tatcaaaaga ttatataaaa gcaaagtcta taatagggtt agttccacaa gaattagcaa
     1801 ttatagaaac tcttactcct tttgataact tagagtactt tggagctttc tacggtttaa
     1861 agggaaaact acttaaagaa agaatcattg aagcattaga agttacaggt cttactgaag
     1921 tcaaaaagaa aaaggtcaaa aaattatctg gtggtatgca aaggagatta aatattggaa
     1981 tagcactctt aaatcatcct aaaatattaa tattggatga accaactgta ggtgtagacc
     2041 cccaatcaag aaatcatatt ttcaatttta taaaagatat atctaaaaaa catgaaacta
     2101 ctgtaatata tacttcccat tatatggaag aagttgaaca cctttgttct aaaattttta
     2161 ttatggatga aggtaaagaa attgcttttg gagataatga ttatttaaaa tcactcgtat
     2221 ctacaaatac aaaattaatt atagaaataa aaaatataaa tgcccaactt atctttgatt
     2281 taaaaaatac taaaggtgtt atatctgttt tagaaaataa ttcattatta gaattggata
     2341 tagataaaaa attacaactt acagatatac tctctgttat tgacaaaaac aattcaaaaa
     2401 taatgaaaat ttcttatgaa gaacctagcc tagaagacgt atttttaaat ctaacaggaa
     2461 aaaatttaag ggactaatgg aggtgatttt atgaaattat acatgagtgt aaaaactatg
     2521 ctaaagagtt taaaaagctc ctttatactt aatttaatat attttttagc tttgcctctg
     2581 attttatctt ggtttcttgg gatggttaca gaaagcatgt ttcaaaaccc tataaaaaca
     2641 gaatctaccc ccattgttat atatgacaaa gataacacaa gattatcaaa tgatttgaca
     2701 aagtatttga aaaatgattt atcttatata ttaacagtta aaaaagatga ttctaaggca
     2761 gaattaaagc ttactatacc taaaggctat gagagtagtt tattaaatga aaaatcaaat
     2821 actctaaaca tagaaaaact tggaactcgt gatgatattg caatattgct tcaagatata
     2881 ttagatactt accatgaaaa attttattta aataattctc agaaaataag ttcagaagat
     2941 ttttctaaat tatttaataa aaattctatt gatacttcta taataaataa caatgttaaa
     3001 cagaactctt atgaatactt tgctttagtt tcactaggat ttcttgtaat aatttttata
     3061 atgaacaata ttttgtcaaa ttatataagt gaatcaaagg gactttcaaa aagactttat
     3121 tctatgccta taactagagt acaattctta atttatgact ttgtaggttt atggatttat
     3181 tcatttatat tcttattatt atatgtttta ttctttagaa tacttggaat aacatttaaa
     3241 ggtaattttg ccatattgct cctactttgt gctttatcat cttattttat gacttcaata
     3301 tctacctttg taaccagctt ttttagtaaa aaatacggta cagcaatagt ttatgcatta
     3361 ctctttttac agacaatttt tggaggtatc ttcagtatga taagtgatac atttactaag
     3421 cttacaagtt tatctcctac ctatttaata ggagaattgt ttagtaatta tgaaacattt
     3481 aaaactatag attcaatagg agatttaatt ttcacatgtt taattatctc tacaatatta
     3541 attgcacttg ctattgtaaa ggaaaaatat aaatggaggg aggtttaata atgattagat
     3601 taactattgc aaatataaaa agatatctaa aaaatcataa tcttttaatt aatatggtta
     3661 tgcttcctat tatactaatt ttttcactta atttttttat caacaactca ggaaatcaat
     3721 caatgtactt ttctccagta gcaattgtat ctgactcttc aggaaagtat gaacataagt
     3781 taataaatag ttctaaatta aaagaaaatt catttagatt aaatgaacta gataaggcta
     3841 tgaatctatt aaaaaataat aaggtttctg ctgtattcgt tttagataaa aatttttcaa
     3901 atagtataga taaattacaa cgacctgtag ttaaatgctt taaaattgaa aatggtggtg
     3961 gtagtctttg ggcagaatca caaatagaat cttttattac taaatcgtta aaattgaaag
     4021 tggataaaaa tatagatgat aaattgacaa agacaaatat aattgataac aaaccagata
     4081 agaataaagg ttcattttta gtagtcttct tgatatgcta ttttatgtat attaatgcag
     4141 cacatcttgc ttctgattta tttacattaa aaaaatcaaa tgtgctaaaa agacttatct
     4201 ctacagataa taaagatata aaaataattt tcagtatatt tttaggacta ttttttattc
     4261 aatcaattgt atacactttt gctctattat gtttttcaat tatagaagac tttaatttga
     4321 gtctgaatgt attgatgatt gtactagcaa atagttttgt ttccactgga tttgtatttt
     4381 gggtagctag agtatttaaa aatgaaagtt ctataagtct tatatctaca ttttattctt
     4441 taataggtct agctatatct atctctagtc taataccatc aatggataaa ttatccttta
     4501 tgactaatct ttcaaagttc acaccatttt attggactat agatgctatt aaaaacaatg
     4561 gtagtatttt aataaatata atagctctaa tattaattgg aattatattt gtaactgcag
     4621 gaagtcttaa actaagagat tttgctaaaa actaataatt attaaatata attagtatct
     4681 atttttatat agttgtaaaa gaatatttca acatattaaa ttattttatc ttatattttt
     4741 ctctttagtt tcacacatca ccaagtctaa accttatatt atatattaat atttttgact
     4801 tgtcaagtta tttatgttat aatattaatc attagataat taaagcattg tacctaagtt
     4861 gcaatatcta aaattcaatt tggaggtata actagcatat gtataaaatt ggtgaaagtg
     4921 taatgtatcc aaaagaggga gcctgctctg taaatgatat tgtaacaaag aaaataaatc
     4981 atgagatgca aaaatactat gaattaagtg tcatttttaa tagtaacctt aaaatttcga
     5041 ttccagttct aaatgcagat agaattggca tacgtccagt tatggatgga aatgatgttg
     5101 ataattttat ccaatctatt aataaaacag atggtgtatg gatttttgat agaaaagaaa
     5161 gacttaaact gtaccaagat aaatttcatt caggagatgt ttttgaaatt gtaaaattaa
     5221 tcaaaatgct tatgatacaa gacagttcaa aacaattgtg tagcacagat aaggagtttt
     5281 taaataaagc tcaaaaattt gctttatcag aattagctgc tgctcaatgt aaatcctata
     5341 caatggtatt agaggaaatg aaaaaacata tattaaattc aaagaataca aattaaacca
     5401 gttttttaaa ctggttttat tttttatact aatcatccat gctactttag cttattttaa
     5461 actgcctaat ctaatattaa taaagttatc tcaattagat agatgtattt tattcaaata
     5521 aaaaaaacta agagtaaatc atattactga tttactctta gctaataaaa tttaatcttc
     5581 ttcaagttct tttttctctt gtaataatac acttaattca tttgcttcta aaacttgtgc
     5641 ctctgcaata tcaagtaact cttgttgcca ttccacacat ttatctttgt aatcaaaagg
     5701 tagcgttctg tcaactatgt acttatcaat acagtcctcc gcacttttaa ttatttcttt
     5761 tctttcatca ataaattttt ctaattctac taaggcttct tcataagctt ttctactcat
     5821 ataaattccc cctttgtaca attattctac attaaaatga tttttcctct tttttgtata
     5881 aaattttatt tgtatataac ttttccatca atatctttta tagtttgaca tccagttaat
     5941 atcatagaac tacttagctc tgattgaagt ttatttacat aagtttctac accatcagtt
     6001 gcaccaccaa aagaagcagt cacaaaaggt cttcctatta atactgcatc tgcacctaaa
     6061 cctatcattt ttagtacgtc taaaccagtt ctcactccac catctgcaag tattgtaact
     6121 ttacctttaa cagcatcagc aatttttggt aaaacttcac atgctcctgg tgtacagtca
     6181 agcactcttc ctccatgatt tgatacaact attgcatcca cacctgcttc tactgccatt
     6241 aaagcatctt caacagtcat tatacctttc aatataaatg gtagtttagt agactttact
     6301 aactccttta tttgtttaac atttttagga agtactggtt ttccatgtaa tgataaagtt
     6361 actagaccac aggcatctat atcaactcca actgcaaatg caccagcttc ttcagctaat
     6421 cttatctttt ttataatatt ttcattatcc caaggtttaa taaatacaat tccagctcca
     6481 ttatactttt tgactacatc taaattttcc attaaaaaag catctactgc cgtatcacca
     6541 accattgcat aaataccact attagcacat cctgcaacta ctggttctat gtaatctctt
     6601 tcattaattt ttccacccat atttaaagta gttcctgtta ctggagctgc aaatataggt
     6661 gcactcattt tctttccaaa catctctata gatgtatcag gatttgatac atcatgtatt
     6721 actctcatat ttacttttac tttttctaaa ctcttgctat tttctataaa agaagaacca
     6781 cttcctttac ctcccatgcc aggcacttca cctgcacaag caaccccatt acaaacctta
     6841 caaactttac aacttccatt taaattttct ctagcacttt ttaataattc attatattcc
     6901 atctttaatc ccccattaac tatagtaatt tatattatat acattatatc atattatatt
     6961 tacagtatat ttttcaaaaa actttttctg tggataggag ttatgccata tttttcaata
     7021 gcttcatagt gttctttagt tccatatcct ttgtgagatt taaacccata ttctgggtat
     7081 actctatcat attggtacat tatactatcc ctagtaactt tagcaagtat acttgctgct
     7141 gctattgata tagattttga atctcctttc acaattggat tttgagatat gtcaatacct
     7201 ggtattgttg ctgcatcaac taataaataa tccggtgctt tttttaaaca atttatagcc
     7261 tttttcattg ccatatatgt agcatttaat atattaaatt catctatttc ttcattgttt
     7321 actataccta ttccataatc tagtgcttct tcttttatta cttcaaaaag ttcatctctt
     7381 tttgcctcac tcagtttctt agagtcattt acaccttcta ttttggtatc ttttttaaat
     7441 actacaacag aagctacaac aggtccagca agtggtcctc ttcccgcctc atcaattcct
     7501 ccaatatata aataaccttt atcatagcct tcgttctcaa atatatttat agtttccaat
     7561 ctttcttctt cttttctaat attatccagc ttttttgcta gttttatagc tagaccttgt
     7621 acagattttc tttcatcaac tcttaacagc tctatatatt ccatatattt ttctacttct
     7681 aaagtctcta ttatttcttt aatctccctc acacttttat cctgcatacc attccctcat
     7741 ctttcgtttt taaaaattta atttttaaat atattaaaat tttttaatta gagtttaatt
     7801 gcatccacta tagccacatt ttaaacatat actacatcca cctgtatgtg caattccttc
     7861 acttccacac tcaggacaca caaatttttc atcttcttca aaatttttat ttattatttc
     7921 tttggctttt tcatctttat tatctttttc ttttttatta tttttataat attctttttt
     7981 actattttct tttttatctt ctttattatt ttcttccttt ttttcattta ttaaaattcc
     8041 actcctttta catccatctc taaatattgt tactccttta agaccagcct cccatgcctt
     8101 aatatatata ttgaaaacat cttcaactgt agtttcaaaa ggtatattta ttgtagatga
     8161 tatagaagca tcaatatact tttgccatac tttttgcatg tttattcttt cttcatatcc
     8221 tatattcata gcagtaacaa aaaaatctgg taaacattct tcatctgtaa tacctttctt
     8281 gtccatatac tctttaacaa ttggagtata tactttataa tacacatcct catcatgcaa
     8341 gctttcagtt tttcttatat atgaaagatt aaatataggt tctattccac cactaatacc
     8401 tatcattgta gatatagaac ctgtaggagg tatggttaaa agttgtgaat ttctaagccc
     8461 atacttttta accatttcct tagtgtcttc atttagattt tctataaaaa acttagattt
     8521 agaaatattt tcatatttat actcactaaa tgttccatat tctttagcaa ttagtgctga
     8581 ttgcttcaca gcttcattta acatagtctt accaattaaa tcacatagtt ctaaagattc
     8641 atcagaacca tatcttattc ccatttttat aagcatatca gctataccca ttacacctaa
     8701 acctatctgt ctatacttat gtacactatc tctttgttct tgtaatggat gcaagttcaa
     8761 tccctcatct aagacatcat ttaaagctac tacagcttct ctaacgcaag attttaattt
     8821 attaatatca aaagtagcat gttcaccaaa tggttgtatt ataaactctg acaagtttat
     8881 tgagccaagt agacaacttc ctccacttgg aagtggttct tctgcacaag gatttactcc
     8941 tgaaaagcaa aagttcttat cttcactcat aaaattatat gtttttattt tatcccaaaa
     9001 caatatacct ggttctgcat aatcccagtt atttttcaca aatttattaa ataaatcata
     9061 agcatttact atcttaacta ttttttctcc agtagtttca acttcaaaag tacaattata
     9121 taactttttt tctcttacag cttgcataaa ttcatctgtt actcttacag aaatatttgc
     9181 tttagtaacc ttctccaaat ctgtttttat atctataaag tcttctatct ctggatgatt
     9241 tacatccata gaaatcataa gagctcctct tctccctctt tgaccaatta agccagttgt
     9301 catactgtaa agttccataa aagagactgc tccagtcgta tgttttgcag cattgttaac
     9361 tttcgctcct tttggtctta gctttgaaat atcaattcca actcctccac cataactaaa
     9421 agttctagca agtttttttg cagtatcaaa tatatcttct atgctatctt ttggtggttc
     9481 tattacataa caattagaat atgttacttt ttttccttct ttctgtaatc ctctatttgc
     9541 taaaattctt ccagcaaata gaaatctttt ttgtcttatt agttttgata ttcttgaact
     9601 attatttgaa attctcttta tccattcatc aaaactctca ccattatgtc tatacttgtt
     9661 cttccatatt gatttttgta attcatcaaa ctcccaagct ttagtcctta tttcagagcg
     9721 tctttctcta tataatatgt agtgttttgc tatatctttt ctatttgatt ccataagtag
     9781 tacttcaact atatcttgta tttcttctac ggataagcat ttttccatag aattatagtc
     9841 attagctatt tttcttgata tatcatatgc caactctcta tctactccac cttcactatt
     9901 tatactagct ttatagacag catcttcaat cttactttta ctaaaaagtt cttttgtacc
     9961 atctcttttt attatgtatt tcatttttaa acctccaata aattagtatt aaattaatac
    10021 acacattaac tataactcta aacaaacttt ttatatattt gtatattttc atatta
//
LOCUS       DAEPID010000109         9901 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.110, whole genome shotgun sequence.
ACCESSION   DAEPID010000109 DAEPID010000000
VERSION     DAEPID010000109.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 9901)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 9901)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..9901
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.110"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            313..960
                     /locus_tag="KR257_003401"
     CDS             313..960
                     /locus_tag="KR257_003401"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889349.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="lactate utilization protein"
                     /protein_id="HBH0032066.1"
                     /translation="MIRQTPLEKRYDKLGPHIVTALKKRYFDAYYCKTRNEALQQILD
                     LIPQNHVVSWGGSETLKEMGVQTAVREKGFKVIDRDLAKTPEERTEIMRQALLCDTFL
                     MSSNAISEDGQLFNIDGNGNRVAAMIFGPKNVIVVAGMNKIVKNIDDAIQRTRTIASP
                     AVVQRFQDVNTPCYINGSCIDCTSPESICAYMVTTRISRPAKKIKVILVGENLGL"
     gene            complement(1127..1696)
                     /locus_tag="KR257_003402"
     CDS             complement(1127..1696)
                     /locus_tag="KR257_003402"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896453.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="lipoprotein"
                     /protein_id="HBH0032067.1"
                     /translation="MKKFIICIIMFAISVLVLAGCTNDNKIKNEVDSMFNSIKTQDAD
                     TVDKYFPKSGLGNLIYEDKEGFKMYSKNMTWEISDIKNNKDKVTVDLKINNTDMVSIL
                     KKNPPKLGEMMPNPTMKDIDSAKKKEFNITLELVKSGDNYVCKVNQESAMKLLNVITG
                     GGIDYLADYNKDYYKQLDEEQKNYENKNS"
     gene            complement(1701..2600)
                     /locus_tag="KR257_003403"
     CDS             complement(1701..2600)
                     /locus_tag="KR257_003403"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893092.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="4Fe-4S binding protein"
                     /protein_id="HBH0032068.1"
                     /translation="MKLLSKVNNNIRLITQVAFTALTNGYVNGFLEGTIYGGESKKLC
                     VPGLNCYSCPGALGACPIGSLQAVLSSREYKFSFYVVGFLMAFGAFFGRFVCGWLCPF
                     GLVQDLLHKVPFPVKIKKVYGDKYLKYLKYIVLIMFVIILPVAIVNVAGGGNPWFCKW
                     ICPSGTLLGGILLILGNENLRESIGFLFSWKLSILLLILLMSIITYRPFCKYICPLGA
                     IYGFFNPISIYRFKIDKDKCTNCTACQTKCKLDIPIYKDVNSPDCIRCGECIKVCPQN
                     AITTTFSKDKKENNICAKKYRGI"
     gene            complement(2611..2760)
                     /locus_tag="KR257_003404"
     CDS             complement(2611..2760)
                     /locus_tag="KR257_003404"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889347.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0032069.1"
                     /translation="MSNFIKDNKKGISIIAISIIFIALGTYRGETNTVLTKAIMICLE
                     CIGIG"
     gene            complement(2753..3337)
                     /locus_tag="KR257_003405"
     CDS             complement(2753..3337)
                     /locus_tag="KR257_003405"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003439354.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TlpA family protein disulfide reductase"
                     /protein_id="HBH0032070.1"
                     /translation="MKRFFIVVLGCICVLGMISGCSKKESKPVEKNKNNSEWFSNLDT
                     EDVDGNKVTKEIFSNKELTLINVWTTWCGPCVGEMPELEALSKEYESNNSNVAIKGLV
                     VEVDKTDMRTGLSNEEKNLVKDIMKKSDATYQQLTVSEELKKTDFKRVMEFPTTYFVD
                     KKGNFVGEKVVGANSKEDWKKIIDERLKMVKANE"
     gene            3726..5051
                     /gene="cdeA"
                     /locus_tag="KR257_003406"
     CDS             3726..5051
                     /gene="cdeA"
                     /locus_tag="KR257_003406"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902537.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="multidrug efflux MATE transporter CdeA"
                     /protein_id="HBH0032071.1"
                     /translation="MENLFTRKFTTFEFLKFVSPAIISMIFISLYTIIDGIFVSTLVG
                     SDALASINIVLPIINLVCGFGIMMATGGGAIVSIRMGENRQDEANSTFSFIVLFSLIV
                     GILFTVISYFFIKEISILLGATDKLLPYCITYGKVMILCTPFYILKFIFEYFARTDGN
                     SKFSLFLSVIGGVTNIILDYVFIKYFGMGLLGAAVATAIGIILTCVLGIIYFLSNKST
                     LKLRKPKTDFRLIRDTMINGSSEMVTELSTGITTFLFNVVALKLAGENGLAALTIVLY
                     AHFLMTSVYLGFAAGVSPLISYNFGAENSDKLKETFKHSLKFIFISSLLVFIIALVFA
                     PFIVRVFVNPDNTVFKLALQGLKIFAFAFLFVGINIFASGFFTAFHNGKISAIISFSR
                     AFVFIIIGIIILPPMLNMTGLWLTVPFAEVITIFISILFIKKYKCRYKY"
     gene            complement(5146..5940)
                     /locus_tag="KR257_003407"
     CDS             complement(5146..5940)
                     /locus_tag="KR257_003407"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420000.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBH0032072.1"
                     /translation="MNELKPYIKFFNKNTKLYIIIFMIVGIVMNILPVFILKIFGEAS
                     KTNLSTIVNPILTYITILLFVYGVNIANKDFSGALSIRADRKSCIKAIVIDLIILSFV
                     ISILGIVLIFLSKLFIEIITGYSIELSVLLKRDMIWTSISALIDPSTSSMPLTYLNYF
                     VQICINEICIGFIGVLLGAFTYRVRKVTSITILIGLPILMVIYIVNFATKNMHKMLLY
                     LEKIIYSFQNPFILFGTKVGIIVICIIFIILLLRKAPIKEYANDLL"
     gene            complement(5941..6816)
                     /locus_tag="KR257_003408"
     CDS             complement(5941..6816)
                     /locus_tag="KR257_003408"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896447.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBH0032073.1"
                     /translation="MSSSIKIENLSHSFKKQNIFNNMSLNFEKNKIYGLLGKNGAGKT
                     TLLNIMVNQLIQNEGEIEILGKNPKEDIKVLEEVCIVREKEFYSPDFKVGQIFEFSSS
                     FYKSYDKGLEKELCKYFDLNTKKKYKQLSRGMKTILSNIIGICSNSAITIFDEPTIGL
                     DAVNRQEFYNIILDSYIKNPRTIIISTHLIDEIDDLLEHVIILNEGKIIIDEEIDVIK
                     QKAHYITGNKEELEKLECIKNIKPKKAFGNAVAYFYYGDFSENDEKILKNSNIDVGYI
                     GLQDMFVNMTKKEEL"
     gene            complement(6820..7188)
                     /locus_tag="KR257_003409"
     CDS             complement(6820..7188)
                     /locus_tag="KR257_003409"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419996.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GntR family transcriptional regulator"
                     /protein_id="HBH0032074.1"
                     /translation="MKLVLNNEEPIFIQIARAIEDEILSNGIKEEEQVPSTTELSKLY
                     KINPATVLKGINILVDKNILYKKRGIGMFVSDGAKTIIKEARKENFKHNFVKNLLQEA
                     NKLEINREELVDIIINFKED"
     gene            complement(7371..8030)
                     /gene="deoC"
                     /locus_tag="KR257_003410"
     CDS             complement(7371..8030)
                     /gene="deoC"
                     /locus_tag="KR257_003410"
                     /EC_number="4.1.2.4"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003439345.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="deoxyribose-phosphate aldolase"
                     /protein_id="HBH0032075.1"
                     /translation="MKHILKTVDHTILKATTTWEDIKILCDEAVDMSVASVCIPPSYV
                     KRASEYLKGKIKICTVIGFPLGYQTTATKVFEAKDAIENGADEVDMVVNISDIKNKDY
                     DNIGKEIKEIKKAIGDKVLKVIIETCYLDEDEKIKMCEIVTMSGSDFIKTSTGMGTGG
                     ATLEDIKLMKEHVGKNVKIKAAGGVKSISDAEKFIEAGAERLGTSSICKILKNEDTTD
                     Y"
     gene            complement(8066..9253)
                     /gene="murJ"
                     /locus_tag="KR257_003411"
     CDS             complement(8066..9253)
                     /gene="murJ"
                     /locus_tag="KR257_003411"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896445.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="murein biosynthesis integral membrane protein
                     MurJ"
                     /protein_id="HBH0032076.1"
                     /translation="MKQEPCDFSHGRFRTGIIFIGITSVMSAFLQIKENFIVVGFGSI
                     PYNIVIIISIMLSTIFGPYILPIGAVVAMVVQLLFYMFFVKKTNYKYLYYLNFKDDSL
                     IKLLALLSPVFIGVAVNQVNSLVDTTLASTLVKGSIPALTYADRLNGFVTGTFTASIV
                     SVMYPMLSKLSAENNQKKFTSSVKSSINMIIISMIPISVASIFFATPVVRIIFERGAF
                     DARATQMTATALIFYAVGMTAFGLRDILGKVFYSLQDTKTPMVNGIISVGVNIVLDLV
                     LIKPMAHGGLALATSSSSIACILLLFLNLKRKVGYFGQDKIIKATLKSVVASLIMGVL
                     SYFTYKFIFGILGVGTFNEFVSLAISVIVGGGIYTLLMTIFKVEEVDMILNIAKRKLH
                     LKK"
     gene            complement(9330..>9901)
                     /locus_tag="KR257_003412"
     CDS             complement(9330..>9901)
                     /locus_tag="KR257_003412"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888399.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=3
                     /transl_table=11
                     /product="transposase"
                     /protein_id="HBH0032077.1"
                     /translation="LDLGIKEFCISSCGEFIENPKYFKKSLNKLAKLQRELSRKTIGS
                     LNRNKARLKVARLQEHIANQRNDFLQKLTTKLIKENDIICIEDLQVKNMIKNHKLSRL
                     ISDVSWSEFIRQLEYKANWHGRQIVKVGKFFASSQICNKCGYKNEEVKNLNIREWICP
                     SCNETHDRDINASRNILKEGLRLITIQNK"
BASE COUNT         3365 a         1584 c         1080 g         3872 t
ORIGIN      
        1 aaacttataa aatttaaaca agttattcat aaaataaaat aataatcatc tataacccac
       61 aactttattt tatattaaat aaaaagtatt agtgattatg ttttataggt atttctttat
      121 tcagttattt attaaaaact aatagtaaat cttatactaa tcgcatattt atgttataac
      181 tatattgtaa ctattttcgt aatcttagga aaagattact tataaaatta accttataca
      241 ataatatatc gtataatctt aattagcata atagttacaa tattaaaatt taaatatggg
      301 agtgatttta gtatgataag acaaacacca ttagagaaac gatatgacaa gctaggtcct
      361 catattgtaa cagcactcaa aaaacgttat tttgatgctt attactgtaa aactagaaat
      421 gaagctttgc aacaaatttt agatttaatt cctcaaaatc atgtagtatc atggggagga
      481 tctgaaacac ttaaagaaat gggcgtacaa actgctgtta gagagaaagg atttaaagtt
      541 attgatagag atttagcaaa aactccagaa gaaagaactg aaattatgcg tcaagcactt
      601 ctatgcgata cttttttgat gagtagcaat gcaattagtg aagatggaca actctttaat
      661 attgatggaa atggcaatcg tgtagctgca atgatatttg gtccaaaaaa tgttatagtt
      721 gtagctggta tgaataaaat tgtaaaaaac attgatgatg caatacaaag aactagaaca
      781 attgcatctc cagcagttgt tcagcgtttt caagatgtca atacaccatg ctatattaat
      841 ggaagttgta tagattgcac aagccctgaa agcatttgtg catacatggt tactacaaga
      901 atcagtcgtc cagcaaaaaa aataaaggta atattggtag gagaaaatct tggtctataa
      961 aatatacata catgtaaata gctctataaa taataaaatc atatgaaata acttatttct
     1021 aaaagtggta gaataaaagc ttctacaaga ctttcattct accactttta tattctttta
     1081 atttgtgttt ctatattatt aattgctccg attttcatat atattactaa ctatttttat
     1141 tttcataatt tttttgttct tcatcaagct gtttataata atctttatta tagtcagcta
     1201 gataatctat accacctcct gtaatcacat ttaataattt cattgcagat tcttgattaa
     1261 ctttacaaac ataattatca ccagatttaa caagctctaa tgtaatatta aattcttttt
     1321 tctttgcaga atcaatatct ttcatagttg gatttggcat catttctcct agtttaggag
     1381 gattcttttt taaaatagaa accatatcag tattgttaat ttttaaatct acagtcactt
     1441 tatccttatt attctttata tctgaaattt cccaagtcat atttttagaa tacattttaa
     1501 atccttcttt atcttcgtat ataagattac ctaaccctga ttttgggaaa tacttatcaa
     1561 cagtatctgc atcttgtgtt tttattgaat taaacatact atccacttca ttttttatct
     1621 tattatcatt agtacaacca gctaacacca gtactgatat tgcaaacatt ataatacata
     1681 taataaattt cttcattaaa ttatatcccc ctatactttt ttgcacaaat attattctct
     1741 tttttatctt ttgaaaaagt tgtagtaatt gcattttgtg gacaaacttt tatacattca
     1801 ccacacctaa tacagtctgg actatttaca tctttatata ttggtatatc aagcttacat
     1861 tttgtttgac atgctgtaca atttgtacat ttatctttat caattttaaa tctatatatt
     1921 gaaataggat taaaaaaacc atagattgct cctaaagggc atatatactt gcaaaatggc
     1981 ctataagtaa tgattgacat caataatatc aatagcaaaa tacttaactt ccagctaaat
     2041 aaaaatccta ttgattctct taaattctca tttcctaaaa taagtagtat tcctcccaaa
     2101 agtgttcctg aagggcaaat ccatttacaa aaccaaggat ttccaccccc tgctacattt
     2161 acaatagcaa ctggcaaaat aattacaaac attattaaga ctatatactt tagatatttt
     2221 agatatttat caccataaac tttttttatc tttactggaa agggtacttt atgtagtaaa
     2281 tcttgtacaa gtccaaaggg acaaagccaa ccacaaacaa atctgccaaa aaaagcacca
     2341 aatgccatta aaaaaccaac aacataaaat gagaatttat actctctgct tgataaaact
     2401 gcttgtaatg aacctattgg acatgctcca agtgcacctg gacatgaata acaattcaat
     2461 ccaggtacac ataatttttt actttctcct ccatatatag ttccttctaa aaatccattt
     2521 acatatccat ttgttaatgc tgtaaatgca acttgagtaa taagtcttat attattattt
     2581 accttagata ataacttcat ccctcttctc ctaaccaata ccaatacact caagacaaat
     2641 cataattgct ttagttaata ctgtatttgt ttctccacga tatgtaccta atgcaataaa
     2701 tataatacta attgcaataa tagaaatgcc ttttttatta tctttaataa agttactcat
     2761 tggcttttac catttttagt ctttcatcta taattttttt ccaatcttcc ttactatttg
     2821 cacctacaac cttctcaccc acaaagtttc ctttcttgtc tacaaaataa gttgttggaa
     2881 actccataac tcttttaaaa tcagtttttt taagttcttc agatacagtc aattgttggt
     2941 aagttgcatc tgactttttc ataatgtctt taactaaatt tttctcttca tttgaaagac
     3001 cagttctcat atcagtttta tcaacttcta caactaatcc ctttatagct acattggaat
     3061 tattactctc atattctttt gataatgctt caagctctgg catttcaccc acacatggtc
     3121 cacaccaagt agtccagaca ttaataagag taagttcttt atttgaaaat atctcttttg
     3181 ttaccttatt tccatcaaca tcctccgtat ctaaattact aaaccattca ctattattct
     3241 tgtttttttc tactggctta gattcttttt tgctacatcc agaaatcata cctaaaacac
     3301 aaatacatcc taaaactact atgaaaaacc ttttcatatc tcacactcct agaatttata
     3361 tagtatataa aatcgctgct tgaaataaaa ataacttatc ttctatatta aagtaattat
     3421 atttaataaa taagagctaa tttaaaaaaa gatatacagt taaaatctat ttcttttcag
     3481 acaaaatctt atatatatat aatagcttgt aaatcttaag attatataca tatatttcta
     3541 aagattttct taagaaacag ttagatttta ctaatataag tttattaatt agcattatac
     3601 taatttatct taatatgatt ttttgttgat tttaagctgt ttatcgtata aataaaattt
     3661 ttcttgacta tatagttact atatagctta ttatatatag agagtaataa aaggaggtaa
     3721 aatttatgga aaatttattt acaagaaaat tcactacttt tgaatttcta aaatttgttt
     3781 ctcctgcaat tatatccatg atatttatat ctttgtatac aataatagat ggcatctttg
     3841 tatcgacatt agttggttct gatgctcttg ctagtataaa tattgtacta cctataatta
     3901 accttgtttg tggatttgga ataatgatgg caactggtgg aggtgctatc gtttctatac
     3961 gtatgggtga aaatagacag gatgaagcca actctacatt ttcttttata gttttgtttt
     4021 cattgattgt tgggatttta ttcacagtaa tctcatattt ctttatcaaa gaaatatcta
     4081 ttttgcttgg tgcaacagat aagttattac catattgtat aacttatggt aaagttatga
     4141 ttttatgtac accattttat attttaaaat ttatatttga gtactttgca agaactgatg
     4201 gaaattctaa atttagttta tttctatcag tcattggtgg tgtaacaaat ataatattgg
     4261 attatgtatt tattaaatat tttggaatgg gtcttttagg agctgcagtt gcaactgcta
     4321 taggtattat tttaacttgt gttttaggta ttatttactt cttatctaat aaatctacac
     4381 taaaattaag aaaaccaaaa accgatttta gacttataag agatactatg ataaacggtt
     4441 cttctgaaat ggttacagaa ttatctacag gaattacaac attcttattt aatgtagtag
     4501 ctttaaaatt agcaggagaa aatggacttg ctgctcttac tatagtattg tatgctcatt
     4561 ttttaatgac atcagtctat ctaggattcg ctgctggagt gtctccatta ataagctata
     4621 attttggtgc tgaaaacagt gataaattaa aagaaacatt taaacattct ctaaaattta
     4681 tatttatttc ttctctttta gtgtttatta ttgctttagt atttgcacca tttattgtta
     4741 gggtctttgt aaatccagat aacacagtat ttaaactagc cttacaagga ttaaaaatat
     4801 ttgcatttgc ttttttgttt gttggtataa atatatttgc atcaggattt tttacagcat
     4861 ttcacaatgg aaaaatttca gctattatat cttttagtcg tgcctttgtt tttataatca
     4921 taggaatcat aattcttcct cctatgttaa acatgactgg attatggctt acagttccat
     4981 ttgctgaggt tataaccata tttatatcta ttctatttat aaaaaaatat aaatgtagat
     5041 ataagtatta aaaattaata cttaaaatca acatttatta aaactaataa acctgcttta
     5101 aaatacaaat ttacaaattt gatttttaag caggttttat tttagttata ataagtcatt
     5161 tgcatactct ttaattggtg cttttctaag taataaaatt ataaatatta tgcaaataac
     5221 tataattcct acctttgttc caaataaaat aaaaggattc tgaaatgaat aaataatttt
     5281 ttctaaatac aatagcattt tatgcatatt tttagttgca aaattaacta tataaattac
     5341 cattaatatc ggtaatccta tcaatatagt aatactagta acttttctaa ctctatatgt
     5401 aaaagctcca agtaacactc ctataaaacc tatacatatt tcatttatac atatttgtac
     5461 aaaataattt aaataagtta gtggcatact tgatgttgaa ggatctatca gtgctgatat
     5521 agatgtccaa atcatatctc tctttagtaa aactgatagt tctatactgt aacctgttat
     5581 aatttctata aataacttcg ataaaaaaat caaaactata cctaaaatag aaatcacaaa
     5641 gcttaaaata attaaatcta tgacaatagc ttttatacaa ctttttctat ctgctcttat
     5701 acttaaagct cctgaaaagt ctttatttgc tatatttact ccatacacaa atagcagtat
     5761 agttatatat gttaaaatag gattcacaat cgtggataaa ttagttttag atgcttctcc
     5821 aaaaatcttg agaataaaca ctggcaaaat attcataaca attcccacaa tcataaatat
     5881 aattatatac aatttagtat ttttattaaa aaattttata tatggcttta attcattcaa
     5941 ttacaattcc tccttcttag tcatgttaac aaacatatct tgtagcccta tgtatcctac
     6001 atcaatattt gaatttttaa gtattttttc atcattttca ctaaaatcac catagtaaaa
     6061 ataagcaact gcatttccaa atgccttttt aggttttata ttttttatac attctaattt
     6121 ttctaactct tctttatttc cagtaatata atgagctttt tgttttatga catcaatttc
     6181 ttcatctata ataatttttc cctcatttaa tattattaca tgctccagta aatcatctat
     6241 ttcatcaatc aaatgagttg atattattat tgtccttgga ttttttatat aactatctaa
     6301 aattatgtta taaaactctt gtctatttac tgcatccaaa ccaattgttg gctcatcaaa
     6361 tatggtgata gctgaattag aacaaatacc tattatattt gaaagtatag ttttcatacc
     6421 tcttgacagt tgtttatact tttttttagt atttaaatca aaatatttgc ataattcttt
     6481 ttctaagcct ttatcataac ttttataaaa actagaagaa aattcaaata tctgacctac
     6541 tttaaaatct ggactataaa attctttttc cctgacaata caaacttctt ccaaaacttt
     6601 tatatcttct tttgggttct ttcctaatat ttctatctca ccttcatttt gaattaactg
     6661 atttaccatt atatttaata atgttgtttt tccagctcca ttcttaccta ataaaccata
     6721 tatcttattt ttttcaaagt ttagagacat attattaaaa atattttgct tcttaaaact
     6781 gtgagataaa ttttctatct taatagaact actcatatat taatcctcct tgaaattaat
     6841 tataatatca accaattctt ctctatttat ttctaatttg ttagcttctt gaagtaggtt
     6901 ttttacaaaa ttatgtttaa aattttcttt tctagcttct tttataatag tttttgcacc
     6961 atctgataca aacatcccta tccccctctt cttatataaa atatttttat caaccaatat
     7021 atttatacct tttaatactg tagctggatt aattttataa agctttgaaa gctctgttgt
     7081 tgatggaacc tgttcttctt cttttattcc atttgatagt atctcatctt caattgctcg
     7141 tgctatctga ataaatatag gttcttcatt atttaatact aatttcatag gttcctcctt
     7201 tctccattag ttagttactc aactaattaa ctatataact tataatatct tgaaaaatat
     7261 tttctgtcaa tactaaataa aaaacagagg gaaaattccc tctgtttttt gttctttata
     7321 tttataatta aattttgatt tttgtaatcc tatcccataa gttaaaaact ttaataatct
     7381 gttgtatctt cattttttaa tattttacat attgagctag ttcctaacct ttctgctcct
     7441 gcctctataa atttttctgc atcagaaatt gatttaactc cccctgcagc ttttattttt
     7501 acattttttc caacatgctc tttcataagc tttatatctt ctaaagtagc tccacctgtt
     7561 cccattccag tagatgtttt tataaaatct gaacctgaca ttgttactat ttcacacatt
     7621 tttatttttt catcttcatc taaataacat gtctctataa tgacttttaa tactttatct
     7681 cctatagctt tttttatttc ttttatttct tttcctatat tatcataatc tttatttttt
     7741 atatctgaaa tgtttacaac catatcaact tcatctgctc cattttcaat agcatctttt
     7801 gcttcaaata cttttgtagc agtagtttga tatcccaaag ggaaccctat cactgtacat
     7861 atctttattt taccttttag atattctgat gctcttttca catatgatgg tggtatgcaa
     7921 actgatgcta cactcatatc tacagcttca tcacataaaa ttttaatatc ttcccatgta
     7981 gttgtagctt ttaaaatagt atggtctact gtttttaata tatgtttcat aaaatcctcc
     8041 taaatttata attaatataa ttagattact tttttaaatg caattttctc tttgcaatat
     8101 tcagtatcat atcaacctct tcaactttaa aaatagtcat tagtagtgta taaattccac
     8161 ctccaactat aactgaaata gctagtgaga caaactcatt aaatgttcct actcccaaaa
     8221 ttccaaatat aaatttatac gtaaagtatg ataaaacacc cataattaaa gatgcaacta
     8281 ccgatttcaa agttgctttt attattttat cttgtccaaa atatccaact tttctcttta
     8341 ggttcaagaa gagtaacaat atacatgcaa ttgatgatga actagttgca agagcaagac
     8401 caccatgagc cattggtttt attaaaacta agtccaatac tatatttacc cctacagata
     8461 taatcccatt taccataggt gtttttgtgt cttgtaatga ataaaaaacc tttcccaaaa
     8521 tatctcttaa gccaaatgca gtcataccaa ctgcataaaa aattaaggca gttgctgtca
     8581 tttgggttgc cctcgcatca aaagcacctc tctcaaaaat gattctaaca acaggagttg
     8641 caaaaaaaat agaagcaact gaaataggaa tcatagaaat tattatcata tttatactag
     8701 atttaactga actagtaaac ttcttttgat tattttctgc acttaactta gataacatag
     8761 gatacataac agatactatt gaagctgtaa atgtccctgt aacaaaacca tttaatctat
     8821 ctgcataagt aagtgctgga atgcttcctt taactaatgt tgaggctaaa gttgtatcta
     8881 ccaatgagtt cacttgatta acagcaacac ctataaatac tggtgaaagt aatgctagta
     8941 atttaataag gctatcatct ttaaagttta agtagtataa gtatttgtag ttcgtttttt
     9001 taacaaaaaa catgtaaaag agcagttgaa ctaccatagc aaccacagca ccaattggaa
     9061 gtatgtatgg tccaaatatg gtacttaaca ttattgaaat aattattact atattatagg
     9121 gtatacttcc aaatccaact acaataaagt tctctttaat ttgtaaaaat gctgacataa
     9181 cacttgtaat acctatgaat attattcctg ttctgaacct cccatgacta aagtcacagg
     9241 gttcctgctt catagaattt tgcatactaa aatatgtctt actaattctc cacaggctat
     9301 ccccgtagtt cctacggttc ttacatacgt tatttatttt gaattgttat tagtcttaat
     9361 ccttctttta atatatttct acttgcattt atatctctat cgtgagtttc attacaacta
     9421 ggacaaatcc attctcttat atttaagttc ttaacttcct cgtttttata cccacattta
     9481 ttgcatattt gtgaacttgc aaagaattta cctaccttta caatttgtct accatgccaa
     9541 ttagccttgt attctaattg acgaataaac tctgaccatg atacatcaga aattaagcga
     9601 gatagtttat gatttttaat catattcttt acttgtaaat cttctatgca aataatatca
     9661 ttctctttta ttaatttagt agttaatttt tgtagaaaat catttctttg attagctata
     9721 tgttcttgaa gtcttgcaac ttttaatctt gctttatttc tatttaaact accgattgtt
     9781 tttctcgata attctctttg taatttagca agtttgttta atgacttctt aaaatactta
     9841 ggattttcta taaattctcc acaacttgag atacaaaatt ctttaattcc taaatctaaa
     9901 c
//
LOCUS       DAEPID010000110         9768 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.111, whole genome shotgun sequence.
ACCESSION   DAEPID010000110 DAEPID010000000
VERSION     DAEPID010000110.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 9768)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 9768)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..9768
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.111"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            complement(431..766)
                     /locus_tag="KR257_003413"
                     /pseudo
     CDS             complement(431..766)
                     /locus_tag="KR257_003413"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003427885.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="Fic family protein"
     gene            complement(864..1544)
                     /locus_tag="KR257_003414"
     CDS             complement(864..1544)
                     /locus_tag="KR257_003414"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003440161.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBH0032078.1"
                     /translation="MIHLMKLELKKVGLKRYFLFSMLGIFLCMFFVFTGLNDKSTSIY
                     DYDVTFRTISLFFCFYYIILFAVLNVAYIINEYTNKTILILFSYPLDRKKLILSKLLL
                     ITTLMISSMIVGYICCFTFVVVLDKYFNLVIGDFHISILSYWIPGAIKSIIVFCSLGI
                     WTFVVGMIRKSIPVTLVSSIIFINLRQFILAGTNTTQDSLISVFIIVGITVIGIYYIL
                     NHKVTEID"
     gene            complement(1541..2467)
                     /locus_tag="KR257_003415"
     CDS             complement(1541..2467)
                     /locus_tag="KR257_003415"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860893.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBH0032079.1"
                     /translation="MNYIIETHQLKKIYKDKAVVNAVNIHVKKGEIYGFVGPNGAGKS
                     TVMKMLLNLVNPNSGEIVMFGKKVAETDFEILKKIGTIIENPYLYENLTAKQNLDLHC
                     EYMGYYNKEHISEVLECVGLSKQSNKKVSKYSLGMKQRLAIARAILTKPELLILDEPI
                     NALDPEGIREMRELFRKLNTDYGITIFISSHILSEVEQIADTIGIIQDGKLIKEISMS
                     DIHKYQTDYVEVDVDNVELAGYLLEKEFGIKDFKITSESCIEIYDLRKDVKEISKIFI
                     QNQIGINSIGRKQSSLEDYFFQTTGTGGKETL"
     gene            complement(2540..3457)
                     /locus_tag="KR257_003416"
     CDS             complement(2540..3457)
                     /locus_tag="KR257_003416"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729264.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sensor histidine kinase"
                     /protein_id="HBH0032080.1"
                     /translation="MELFLVVISIVLFALYLKERNKSKKMESDYKYINSRLRDITNDD
                     EINYILVPSDISIVKETAVDINKLVEKFYSRQINYNRSEKAILQIFTNISHDLRTPIT
                     VLKGYIEMLYLQSQKEELSSSMRAIVEKMQTNSNELVNSINNLFNMAKIQSGDMILNL
                     QKSNLTQLCHEIILEFYDLLDKENFNVEVNIEDRPIYANVDTEALQRILKNLIDNAIK
                     YGSDGRFLGISLYEKEKHVFIDIEDKGSGISETEKEHIFTRAYTADRKKGNGLGLAIS
                     QGLANSMGGSIYVNSRPNVKTVFTVKLKS"
     gene            complement(3457..4146)
                     /locus_tag="KR257_003417"
     CDS             complement(3457..4146)
                     /locus_tag="KR257_003417"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902053.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HBH0032081.1"
                     /translation="MDILLVEDDKNIREMVYDFLISENYSVKTAIDGNTAIEIFKNYS
                     FDIILLDLMLPKSSGFEVLKYIRSVSVVPVIITTAKDSDTDKMLGLNLGADDYITKPF
                     SIVELLARIKANIRRATVYSSSRNSQDMVIRYKDLIINISKYVVSKNGIDLNLTHTEF
                     EIVKLLATNQGRAFSKEQLYNAIWKEPYYGNENVLNTHINRLRNKLSDGIEKNNYIKT
                     LWGIGYKMEEE"
     gene            complement(4554..4849)
                     /locus_tag="KR257_003418"
                     /pseudo
     CDS             complement(4554..4849)
                     /locus_tag="KR257_003418"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003427875.1"
                     /note="frameshifted; internal stop; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
     gene            complement(5923..6141)
                     /locus_tag="KR257_003419"
     CDS             complement(5923..6141)
                     /locus_tag="KR257_003419"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860891.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HBH0032082.1"
                     /translation="MSVLLKTKIKSYREKNLMTQGELAKSVGVRRETIVHLENGRYNP
                     SLKLAMDIAKVFDTTVEELFEFIEENNI"
     gene            complement(6142..6549)
                     /locus_tag="KR257_003420"
     CDS             complement(6142..6549)
                     /locus_tag="KR257_003420"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860890.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0032083.1"
                     /translation="MSKQQTGIKSTLISEILGISYCIGATLVNKYFFKGSSIEYLPII
                     IWVLAMGAQWVYNKKYDDLIDEASKCILSRVNDIAIKVLFFSVAIVSIFLVTLDINVS
                     NLNIGMSLLVILFIQSLLKLILFIYFDRKGIYN"
     gene            complement(6635..7123)
                     /locus_tag="KR257_003421"
     CDS             complement(6635..7123)
                     /locus_tag="KR257_003421"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892711.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3841 domain-containing protein"
                     /protein_id="HBH0032084.1"
                     /translation="MKFYTIQTLEFWNNNKNNKYLSNDYSFILEDFDIPYKWMYSQMT
                     NRIYEFDDSMIWVWTKRPDLRCSGYLEKGKKGVLLEIEISEDNVLLSEFDLWHLPLMD
                     ITVELYEDEQIEKKVSWERIFDLELCSKLNEVNIEDLTLQGVTSKVPLSNVKLIKEFV
                     AK"
     gene            complement(7328..8437)
                     /locus_tag="KR257_003422"
     CDS             complement(7328..8437)
                     /locus_tag="KR257_003422"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902002.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Rpn family recombination-promoting
                     nuclease/putative transposase"
                     /protein_id="HBH0032085.1"
                     /translation="MKEKLEEKSKIIKTSKEYKRTIIEEKDREWTQKLNDILSRGDFS
                     NEKLDKIKDLIPKEILTSENVGEVVTEDGYAKPEYDEVFKSLFTLNNDYDLLANFIND
                     ILKDAPYANRNIKQFTQIKRIIKVETDPTINYIGEKRPRLDILAEDEERNHINIEMQR
                     ALEEDYLERAEYYLSRVHGRKLEEGKEYKEIGKTVGIHILNHVKYNHIEDYVNCLRLT
                     MDGHPDIFSSKTALYFIELPKIRKSSCIANRVLIWGKLIDNPSHIDIRILSKTDYVIK
                     RALDRLKELGSNEDYLLNLKRGAYIMNKSRNFKEEIFQEGIEKGIEKGIAKGKREEKF
                     NIIIKLKNKGYNLSEICDIIDDLNKSEVEKVYNQN"
     gene            complement(8810..8980)
                     /locus_tag="KR257_003423"
     CDS             complement(8810..8980)
                     /locus_tag="KR257_003423"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003427864.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0032086.1"
                     /translation="MDSNNNTIKSTVKKGISFGSCLAMIISYTAWKSIPWAIFHGLMS
                     WIYVLYYWVKYA"
     gene            complement(9152..9595)
                     /locus_tag="KR257_003424"
     CDS             complement(9152..9595)
                     /locus_tag="KR257_003424"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902048.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HBH0032087.1"
                     /translation="MIEIKTIEINKKSQIDLLILADPCEEMIDKYLNKGTMYALYDNK
                     ELTCIAVVNEISKEICELKNIATYEHFQNMGYASKMIYHLLDVYSKKYSSMVVGTSES
                     GVPFYEKFGFVYSHKIKNFFVDNYPEPIFEGELQCVDMLYLSYNF"
BASE COUNT         3374 a         1556 c          928 g         3910 t
ORIGIN      
        1 aataatatgt tacaaaaagt atagcacctt tttatttttt tcgcaataaa taaaaaattt
       61 aaaatttttt attttttatt ttcttatatt atcaatttga aatatgaaag attaagacta
      121 atagaattga ttcagttaat tgaaaaaaat aggtaccttt tatgaaaatt ctaatgataa
      181 gcatttttct gatgtaatgg taaattataa atgataaaat taaaaatcac ttttagtttt
      241 atgaactgtc cccatattaa gaaacaacta agatacataa aaatagttat aaagagatag
      301 ttaaactata tccactattt tatatagtta aaatagtggg tatagtccaa gctaagaata
      361 actaagaaat tagcgttaaa tagcatagat aaaaatatat ttatataaaa actttttttg
      421 ctgcaaacaa ttatttccat aacattttat atacttctct aaaatcttct aaacttgata
      481 aatattcaat taaagggaca taattaccta aactacaaga atttaaggag tttctataca
      541 attcctcact atcccaagat acaattttta taggaagatt attttctaac atctgtttta
      601 gcataacaaa tctacctatg cgaccattac catcttgaaa tggatgtatc aattcaaatc
      661 tataatgaaa ttcagctata actttaatag atacttcact ctgactatag taccattcaa
      721 ttaattcatc aagctttggc tcaacttcaa atggttgtgc aatattatta aaactctaat
      781 aatattaata atagctgata taatagcaaa tcattattat cccaagaaga tacaattaat
      841 aactaccctc ctatccacag tatctagtca atttcagtaa ctttatgatt tagtatataa
      901 tatataccaa tcacagttat accaactata ataaaaacag aaatcaaact gtcttgagtt
      961 gtatttgtac cagctaaaat aaattgtctt aaattgataa aaataattga actgacaagg
     1021 gtaacaggta ttgattttct tatcattcca acaacgaatg tccatatacc taatgagcaa
     1081 aatacaataa tacttttaat tgctcctggt atccaataag ataaaattga aatatgaaaa
     1141 tctccaataa ctaaattaaa atacttatcc aacacaacaa cgaatgtaaa acaacagata
     1201 tatccaacta tcattgatga tatcataaga gtcgtaatca aaagtaactt tgataaaata
     1261 agttttttac ggtcaagtgg ataagagaat aaaatcaaga ttgttttatt tgtatattca
     1321 tttattatat atgccacatt caacacagca aataatataa tatagtaaaa acagaaaaat
     1381 aaactgattg tcctaaatgt aacatcataa tcatatattg aagtagattt atcattcaat
     1441 ccagtaaaga caaaaaacat acataagaaa atccccagca ttgaaaataa aaaatatctt
     1501 tttagcccaa ctttttttag ctctagtttc attaaatgta tcatagtgtt tctttacctc
     1561 ctgtacctgt agtttggaag aagtaatctt ctaaagaact ttgtttacgt ccaatgctat
     1621 ttataccaat ttgattttga ataaatattt tggatatttc ttttacatct tttcgtaaat
     1681 catatatttc aatacaactt tccgaagtaa ttttaaagtc ttttattcca aattcttttt
     1741 ctaacaagta tccagcaagc tccacattat ctacatctac ttcaacataa tctgtttgat
     1801 atttgtgtat atctgacata gaaatttctt taataagttt accatcttga ataattccaa
     1861 tagtgtccgc aatttgttct acctctgaaa gaatatgact agaaataaat atagttattc
     1921 cataatctgt atttaactta cggaataatt ctcgcatttc tcttatcccc tctgggtcga
     1981 gtgcatttat aggttcatca agaatcaata attctggttt agtaagaatt gctctagcta
     2041 ttgcaagacg ttgtttcatc cctaaagaat attttgaaac tttcttgttt gattgctttg
     2101 acaatccgac acattccaat acctctgata tatgttcttt gttataataa cccatatatt
     2161 cacagtgtaa atcaagattc tgtttagcag tcaaattctc atataaatac ggattttcaa
     2221 taatagtacc aatctttttt aatatttcaa aatcagtttc tgccactttc ttaccgaaca
     2281 taactatttc tccagaattt ggattaacaa gatttagcaa cattttcatt actgtacttt
     2341 tacctgcccc gtttggtcca acaaatccat aaatttctcc ctttttcaca tgaatattaa
     2401 cagcattaac aacagcttta tctttatata ttttctttaa ttgatgggtc tctatgatat
     2461 agttcatcat actccctcct ttctaaaaac agtatacaaa ataaaattgt cttttctctc
     2521 ttttaaatct aacttttttc taacttttca attttaccgt aaaaactgtt tttacattag
     2581 gtctactatt tacataaatt gaacctccca tagagtttgc aagcccttga gaaatagcca
     2641 aacctaaacc attgcctttt tttctgtcag cagtataagc tcttgtgaaa atatgctctt
     2701 tttcagtttc agaaatacct gaacctttat cctcaatatc tataaaaaca tgtttttcct
     2761 tttcatatag tgaaatccct aaaaatctac catctgaacc atattttata gcattatcaa
     2821 ttaaattttt gagtatacgt tgtaatgctt ctgtgtcaac atttgcatat ataggtctat
     2881 cttcaatatt aacttcaaca ttaaagtttt ctttatctag caaatcataa aactctaaaa
     2941 taatctcatg acataattgt gttagattgg atttttgaag atttaatatc atatctccag
     3001 attggatttt tgccatatta aacaggttat ttattgaatt aacaagctca tttgaatttg
     3061 tttgcatttt ttccacaatt gctctcattg aagaagataa ttcttctttt tgactttgaa
     3121 gatatagcat ttcaatataa ccctttaata ctgtgatggg agttcgtaaa tcgtgtgata
     3181 tgtttgtaaa tatttgcaat atcgcttttt cacttctatt ataattaatt tgcctgctgt
     3241 aaaacttttc aacaagttta tttatatcta ctgctgtttc ttttacaatc gaaatatcag
     3301 atggtactaa aatataatta atttcatcat catttgttat gtcacgaagt cttgaattga
     3361 tatacttata atcactttcc attttctttg atttatttcg ttcttttaag tagagagcaa
     3421 atagtacaat cgaaattaca actaaaaata actccattat tcttcctcca ttttgtagcc
     3481 aattccccaa agagttttaa tataattatt tttttctata ccatcagaca atttatttct
     3541 taacctgtta atatgagtat ttagcacatt ttcatttcca taataaggtt ctttccaaat
     3601 agcgttgtat aattgttcct ttgaaaaagc acgtccttga ttagtcgcta gtaatttaac
     3661 aatttcaaat tctgtatgtg ttaagtttaa gtcaattcca ttctttgaaa ctacatattt
     3721 tgatatgttt ataatcaaat ccttataccg aataaccata tcttgagagt ttcttgaact
     3781 gctatacact gttgcacgtc taatattagc tttaattctt gcaagcaatt ctacgattga
     3841 aaaaggcttt gtaatataat catctgcacc tagattaagc cctagcattt tatctgtgtc
     3901 actatctttc gcagtagtaa taataacagg aacaacactc acacttcgta tatattttaa
     3961 tacttcaaaa ccactagact ttggtaacat caagtccagt aaaataatat caaatgaata
     4021 atttttaaat atttcaatag ctgtatttcc atcaatggca gttttaacag agtaattctc
     4081 actaatcaga aaatcgtata ccatttctcg aatattctta tcatcttcaa ccaataagat
     4141 gtccattatt attcaactcc ttttcgtcag tatacttcaa atgatatatt tattaaaaag
     4201 ggttgtcaat aaataactgc ttatgatatt gtatctgcaa tttggtgata ctcttctaag
     4261 ttaaagttct tttcaataag ctttattgaa aaaagaatta aaatatagta tactctctta
     4321 tctttatcta aaatatacat aattttcttt tattaacatc tacaattaac tattttatat
     4381 tataaaacac cttttaactt ttgctaaaaa atattttata cataaaaaag aaaccacatt
     4441 ctagttttat acagaacata gtttctttaa aaataatcaa atttggattt taaataatta
     4501 aaaacaaact tttatttgtt tttaattttc caattttata gtagataatt tagttaatta
     4561 gttcttaaat gtttatcttc tttagtaaat ttttttctta ttaagaaata tgcaactatt
     4621 acaacaagtt ctattgctaa aaatacacca taagtagcta tagaatctat gtatctatgc
     4681 catttctaaa gaaaattaaa gcaattcctg ctgctataat acctacagca ttttaatttt
     4741 gaccaaaacc ataaaaagaa gggaaatttc cttttatttc aatgaatgtc aagattaatc
     4801 caatagctat aaatagtact cctacaactt ccataatcat gctaggcatt ttgacccctc
     4861 cttattaata attaactact actataaaaa tatttattat ttttataatt atattatata
     4921 tgcgattaca tgtttttgga agtatatttg gaagtaattt catatttatt taacttaatt
     4981 tttttgtgat aaaataattc taattttcat atagatatta ttataaattt tctagtttat
     5041 ggagttattc attctataat tcacaaatat gtatttttta atctattaaa ctattcattt
     5101 tctggcttat aagcatggac ttcttatcta taagcttggt ttttcatcta ataagttatt
     5161 tattctttaa tctatgagct tgatttttca tctataagtc atttattttt taatctataa
     5221 gtttagttct tcatctataa atcatttatt ttttaatcta taagtttggt ttttcatcta
     5281 taaataagtc atttattttt taatctataa gtttagttct tcatctataa atcattcatt
     5341 ttttaatcta taagcttggt ttttacctat aattaattca ttctctaatc tataagcttg
     5401 gtttttattt ataagtcatt tattctctaa tctataagct tggtttttat ttataagtca
     5461 tttattctct aatctataag cttacttctt aatctataag tcatttattc tctaatctat
     5521 aagcttactt cttaatctat aaatcattca ttttttaatc tattagcttg ttttttacct
     5581 ataattaatt cattctctaa tctataagct ttctttttca tctataaatc attcattctt
     5641 taatctatga gcttggtttt tcatctataa gtcatttatt ctctaatcta taagctttct
     5701 ttttcatcta taaatcattc attctttaat ccattagctt ggtttttcat ctataagtca
     5761 tttattctct aatctataag cttacttctt aatctataaa tcattcactc tttaatccat
     5821 tagcttggtt tttcatctat aagtcattta ttctctaatc tataagcttg gttttttacc
     5881 tataattaat tcattctcta atgcataagt aatacatgaa atttaaatat tattttcttc
     5941 aataaattca aacaactctt ctacagttgt atcaaatacc ttagcaatat ccattgccag
     6001 ttttaaagaa ggattgtagc gaccattttc taaatgtaca atagtttcac gtcttactcc
     6061 tactgacttt gcaagttcac cttgtgtcat aaggttcttt tctctatagg atttaatttt
     6121 tgtctttagt aatactgaca cctaattgta tatccccttt ctgtcaaaat atataaatag
     6181 aattaacttc aacaaggatt gaataaacaa aatgactaat aaagacattc ctatatttaa
     6241 atttgacaca tttatgtcca aagttacaag aaatatagat actatagcta cagaaaaaaa
     6301 caatactttt attgcaatat cattaactct tgatagtata cattttgatg cctcatcaat
     6361 taaatcatca tactttttat tatagaccca ctgagctccc atagctaata cccaaataat
     6421 tataggaaga tattcaatac tacttccttt aaaaaaatac ttatttacta atgtagctcc
     6481 aatacaataa gaaattccca atatttctga aataagtgtt gatttaatac cagtttgttg
     6541 tttagacata taaaatcccc cttaaaaagt tatgtattta taacacctct tgttataaat
     6601 atataacttt tttgaataaa tttcaataaa aatattattt tgcaacaaat tcttttatta
     6661 attttacatt agatagaggc actttagatg tcactccttg caatgtcaaa tcttctatat
     6721 taacttcatt taattttgaa cacagttcta agtcaaatat tctttcccaa cttaccttct
     6781 tttcaatttg ttcatcttca taaagctcta cagtaatatc cattaaaggt aaatgccata
     6841 aatcaaattc tgataataac acattgtctt cacttatttc tatttcaagt aaaacacctt
     6901 tttttccttt ttctaaataa ccactacatc ttaaatcagg tctcttcgtc caaacccata
     6961 tcatactatc atcaaattca tatattctat ttgtcatttg actatacatc catttgtatg
     7021 gaatatcaaa gtcttctaat ataaaagaat aatcatttga tagatattta ttgtttttat
     7081 tgttattcca aaattctaaa gtctgtatag tataaaattt catatataaa tcaacccctt
     7141 tgtttttcta taagaaggag atggttcaaa cttttatttt gaattatctc ctttatttat
     7201 acacctcttt gtacctatta tttatatatc tctttatatc taccatattt aaataacaaa
     7261 gttttatatt aatttaaatt taaaagagga agctttgtat ttatctagtg ccatctcaat
     7321 catagtatta gttttgatta tagacttttt caacctctga tttattcaaa tcatctataa
     7381 tatcgcatat ttcactcaaa ttgtatcctt tattttttaa ttttatgatg atattaaatt
     7441 tctcttctct tttccctttt gcaatacctt tttcgatacc tttttcaata ccttcttgaa
     7501 aaatttcttc tttaaaattt ctacttttat tcataatata cgcacctctc tttaaattta
     7561 ataaatagtc ctcattacta cctaattctt ttaatctatc aagtgctctt ttaataacat
     7621 aatccgtttt agatagtatt ctaatatcta tatgagaagg attatcaata agtttacccc
     7681 atattagaac tctgtttgct atacaactgg atttacgaat ttttggaagt tctataaaat
     7741 ataatgcagt tttactagaa aaaatatctg gatgcccgtc cattgttaat ctcaggcaat
     7801 ttacataatc ttctatgtga ttatatttta catgatttag tatatgtatt ccaacagttt
     7861 ttccaatttc tttatattct ttaccttctt ctaactttct accatgtaca cgactaagat
     7921 aatattcagc tctttccaaa taatcctctt caagagctct ttgcatctca atatttatat
     7981 ggttacgttc ttcatcttca gccaaaatat caagtctagg tcttttctca ccaatgtaat
     8041 taattgttgg gtcggtttca accttaatta ttctttttat ttgagtgaac tgtttgatat
     8101 tcctattagc atatggagca tctttgagga tatcatttat aaaatttgca agtaaatcgt
     8161 aatcattatt taaagtaaac aatgatttaa atacctcatc atactcaggc ttagcatacc
     8221 catcttcagt tacaacttct ccaacatttt cactagtcaa tatttctttt ggaattaaat
     8281 ccttgatttt atctaatttt tcattagaaa aatcacctct actaagtatg tcatttaatt
     8341 tttgggtcca ttctctgtcc ttttcttcaa ttatagttcg tttatactct tttgatgttt
     8401 taataatctt agatttttct tctaattttt ctttcatatc aacacctctt ttttattatt
     8461 acccatttct tcataccaaa gtctgaactt ctaagtaaaa tttgcattat tgaaataaga
     8521 accttataaa cttatatatc attactaaag ttaagacttt aaagagaagc acttagatta
     8581 caatagattt tagatagctt tctttttaaa actattgttg ataaatgaat gaatataagg
     8641 gtatgtatta aaatagagat actcatcttt ttcattgttt aagtaatgaa aatatatttt
     8701 atttaataca aaaaagagtg ccttataaac taaaagttca cttcgagaca ctcccttaca
     8761 ttttgtttct taaactttac aatattacat acttatttat taatttaatc tatgcatact
     8821 taacccaata ataaagtaca tatatccaac tcattaagcc atgaaaaata gcccatggaa
     8881 tagatttcca tgcagtataa gaaataatca ttgctaaaca agaaccaaaa gaaataccct
     8941 ttttaacagt tgattttata gtattattat ttgaatccat aattaatcct ccaaaattca
     9001 aaataaacaa gttattatat atcttatttg aatctaatac aatataacag cttctaaata
     9061 aattatactc ttattataca taatttataa attataattc cgataattat atgaattaat
     9121 taattatatt aacctaaaaa tattatccta tctaaaagtt atatgataga tacaacatgt
     9181 caacacattg taattctcct tcaaagattg gttctggata attatctaca aaaaagtttt
     9241 taattttatg tgaataaaca aatccaaact tctcataaaa aggaactcca ctttcagatg
     9301 taccaacaac cattgatgaa tattttttac tataaacatc taaaagatga taaatcatct
     9361 ttgaggcata acccatattt tgaaaatgct catatgtagc aatgtttttt aattcacata
     9421 tttctttgga aatttcattt acaactgcta tacaagtaag ttctttatta tcatacaatg
     9481 cgtacatagt tcctttattg agatatttat caatcatttc ttcacatggg tcagctaata
     9541 ttaaaaggtc aatttgactt tttttattta tttctatagt ttttatttct atcataagtt
     9601 ctccaccctc actttattca aaccttaatt taacaaactt cttacagtac ttatttagtt
     9661 cattttgata tatattttta ctttttaaaa tatagtgata attccctaga atattaatat
     9721 taataataaa ttataatatc agctctagca attacctaga atatcaat
//
LOCUS       DAEPID010000111         9720 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.112, whole genome shotgun sequence.
ACCESSION   DAEPID010000111 DAEPID010000000
VERSION     DAEPID010000111.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 9720)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 9720)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..9720
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.112"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            complement(278..844)
                     /locus_tag="KR257_003425"
     CDS             complement(278..844)
                     /locus_tag="KR257_003425"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429973.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MarR family transcriptional regulator"
                     /protein_id="HBH0032088.1"
                     /translation="MDYSNELKELFLMNQTYATLFTLTNKIQIEGDKYFGILTSRQYM
                     TILSILHLPEEETTLNNIARKMGTSKQNINRLVANLEKNGYVDVIPSPHDKRAINVKV
                     TDLGKKVMVTCSRTGINFMADVFHEFTKDELETLWSLLKKMYRFNGEEQDGFEEDANF
                     MEYEEIDKIKSEALEEFAKRRNRVNKKD"
     gene            1132..2067
                     /locus_tag="KR257_003426"
     CDS             1132..2067
                     /locus_tag="KR257_003426"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436568.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha/beta hydrolase"
                     /protein_id="HBH0032089.1"
                     /translation="MKCTNFTFKGEEGLDIYTYKWEDENIKKPKAVIQIAHGMAETAQ
                     RYETFAKVLTKNGYIVYINDHRGHGKTAKIIENVGHLAEKEGFRCLVEDMYTLTNIIK
                     KENEDLPIYLFGHSMGSFASQRYIMDYSNNLSGLILCGSNGKQGIILNLAHLIINREI
                     KKYGRRSKSNKINNLIFGGEIIRRNEKTKFDWLSRDKEQVEKYINDPFCGVVCSCGFF
                     YDLVQGLKEIEDKENLKKVPLDIPIYIISGDKDPIGKNGKGVLRLRDRYIKLGVKDVT
                     CKLYKDGRHELLNEINREEVFEDIICWLNNKIEIL"
     gene            2532..3746
                     /locus_tag="KR257_003427"
     CDS             2532..3746
                     /locus_tag="KR257_003427"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018112778.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HBH0032090.1"
                     /translation="MQIKIGKVIQCLRKERNLTQEQLAKFIGVSTPAVSKWESGNSYP
                     DIELLPLLADFFNVSIDKLLNYKIDLSEEEVMKIYKELESGFARIEIDLSTEEPKEEF
                     RQDLESVKKLSNMYIEKYPKSYLLKLRICSLYQMYSYKFGKSELNDRVKETMNILEDI
                     VRNTDDIQIKETALIILSNAYCMLEDYEKAELYLNMIHKSIGDTSVNLAMIYLKQNRL
                     EEAEILLQNKLFSNVFNISMDCKGIINVYKNQYKELKKKLENRNFNKNAIEREMEYIK
                     NKLLGYANLSLEIKKMLSEDKGAFFSMYMDYMELSLIFLFFNMKEEAKKALYSLKEIL
                     EKYPIHESLDVSQMRFFDKVESKNLYTFNIYTNLLIVLNDDSYNELREEPIFKDVIEK
                     ILDMEKMLKNKE"
     gene            complement(4166..4687)
                     /locus_tag="KR257_003428"
     CDS             complement(4166..4687)
                     /locus_tag="KR257_003428"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902626.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HBH0032091.1"
                     /translation="MKFKRLRTSENKLCYKAMELYKISFPFHEQRKSSLQEEILKNKE
                     YQFNLIYDKNQFVGIILCWETDDFIYVEHFCIFPEMRNNRYGQRALELLNKKGKTIIL
                     EIDLPIDEISIYRKAFYERVKYKTNNYEHIHPPYHEKFNGHNLIVMSYPEKLSKMEYD
                     KFNHYLRNNVMSF"
     gene            5043..5840
                     /locus_tag="KR257_003429"
     CDS             5043..5840
                     /locus_tag="KR257_003429"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902627.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="G5 domain-containing protein"
                     /protein_id="HBH0032092.1"
                     /translation="MEKREKRIIISSLLSVSILMGLVSIYSILNKEDIILTVKGQEQK
                     VSSFKKTVEELLDEQGIKYNSEDKINPSLDTELKDDMKIKVVKVTKSKKEEIEKIPFD
                     TKHVNDSNLLKGKSKVYQEGQEGEKKLVYNLTYHDGKLVKKVLSKEVISKEPTTKIIK
                     YGTKEKVLIASRGANIRGGKHMKVVATAYAGDTITSTGTTPRWGVIAVDPRVIPYGTK
                     VYIPKLGMTFVAEDCGGAIKGNRIDIFMNSEGKASNWGRKSIDIYLH"
     gene            5950..6540
                     /locus_tag="KR257_003430"
     CDS             5950..6540
                     /locus_tag="KR257_003430"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429982.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SGNH/GDSL hydrolase family protein"
                     /protein_id="HBH0032093.1"
                     /translation="MKIVCLGDSLTYGFGVSRSNSWTNIVNKETRLEIVNKGINGDTT
                     SGMLARFNEDVVKNSPDIVFIMGGTNDFIAGAGNEIINSNIMAMVHQSYSKNIIPIIG
                     IPLKPDIPNVREDWSCFTDFNIVSQNLESYSYWIKKFCMTFNTNFVDFYSEYNKNMEL
                     EGYKKLYFDGLHPTKEGHRIMADIFINSINKYIEEL"
     gene            6606..8303
                     /locus_tag="KR257_003431"
     CDS             6606..8303
                     /locus_tag="KR257_003431"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902629.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phospho-sugar mutase"
                     /protein_id="HBH0032094.1"
                     /translation="MDYTKTYEEWIKGSYFDEDTKLELENIKNNEKEIEDRFYKDLEF
                     GTAGLRGIIEAGTNRINKYTVRRATFGLANYILENTTKEETSRGVVIAHDNRHKSRQF
                     CIESANTLAACGIKAYIFDSLRTTPELSFAVRSLNAIAGIVITASHNPPEYNGYKVYW
                     EDGAQVMPEIANAITEKVNSIHDYSTIPTLTEANKNLVVLLDESQDTKFIEAVKSQII
                     RKDLVKNVGKSFKIVYTPLCGTGNVPIRRALKEVGFENIIVVPEEENPDPNFAGLDYP
                     NPEEKKALNRGILLAKEKGADLVIATDPDCDRVGVAVKTTTGEYALLTGNQIGGMLTH
                     YIIEGLKENNKLKENPTIIKTIVTSEFGADIAKANNVDVLNVLTGFKFIGEKIKLFEQ
                     NKNRSYVFGYEESYGYLVGTHARDKDGVVSSLLISEMAAFYYSKGMSLYDGLIELYKK
                     YGFFKEQTISLTLKGIEGVEKIKEIISYFRENQIDYINSIKVVDKKDYKNGIDNLPKS
                     DVLKYFLEDESWVAIRPSGTEPKLKFYIAVKGASDIEADKKIQGLKKYIDDMVEKLK"
     gene            8517..9356
                     /locus_tag="KR257_003432"
     CDS             8517..9356
                     /locus_tag="KR257_003432"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861260.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YihY/virulence factor BrkB family protein"
                     /protein_id="HBH0032095.1"
                     /translation="MFGIDKKLIEYIIAKSNYSELSSKSAEVSFFLMLSIFPFLIFTI
                     SSIAYIPILHLNKYIALFRNMMPEGAFAVLSSIIVSAIDNRNLKFLAVSFVLTMWTFS
                     RAVKALIKGMNRAYKVKETRSFFKILSISFLFTIMLLVLIFLSMIFLVYGEKIGYFIF
                     NLVGLDEIFIKIWDILRYTVGIITIIVIFTLLYKYTPNKKLTIKESAPGAIFATFAWF
                     LVSFLYSYYTNYYANYEVIYGSIAEIIVLMTWMYFSSWSIVIGYEVNSRLYFRKIRHE
                     MLK"
BASE COUNT         3836 a          969 c         1573 g         3342 t
ORIGIN      
        1 agttattacg tgtgtcaaag taatagttgt agtcaaccaa ttaatgattt acaaaaatta
       61 aaagatatga ttttaggagt agaataatca taatagcgaa aaaggagatg ctttaaaata
      121 aaagtctaat catctccttt ttttgtataa aaaacagaaa aagagttcct aagaacacct
      181 aatctatgta atgattgttt tgttaaaaaa taaaaatgac attatagtta tataaaatat
      241 tgtactataa aaaagtggta ttatagatgc gatagtatta atctttttta tttaccctat
      301 ttcttctttt tgcaaattct tcaagtgctt cagatttaat tttatctatt tcttcatatt
      361 ccataaaatt agcatcttct tcaaagccat cttgttcttc accattaaaa cgatacattt
      421 tttttagtaa actccataag gtctctaatt catctttggt aaattcgtga aatacatctg
      481 ccataaagtt tattccagtc ctactacatg ttaccataac cttttttcct aagtctgtaa
      541 ctttaacatt aattgctctc ttatcatgag gacttggaat tacatcaaca tatccatttt
      601 tttcaagatt agcaactagt ctatttatat tttgtttact tgtacccatt tttcttgcaa
      661 tattatttaa tgttgtttct tcctctggta aatgaagaat tgataaaata gtcatatact
      721 gtcttgaagt aagtatacca aaatatttat ctccttctat ttgtattttg tttgtaaggg
      781 taaaaagagt tgcatatgtt tgattcatta aaaagagctc ttttagttca tttgaataat
      841 ccatgaaata tatctccttt atttttagat gttgttttgt cgaaaacaga atatcatgaa
      901 ttaattctaa tgtcaatatg gtgtcaaaat atattaaagt attacttttt tatgtaacta
      961 ttaattaatt aaattattgt ataattttat gtaaaaactt ctatgtacca atgataattt
     1021 ctatgaggaa ttaataattc ttaaattttt tagaaagatt ttgacttgaa aatacttgta
     1081 atataatata taaattaata tactgaataa aatcaatctg gagggataat tatgaagtgt
     1141 acaaacttta ctttcaaagg agaggaaggt ttagatatat atacatataa atgggaagat
     1201 gaaaatataa aaaaaccaaa ggcagttatc caaattgcac atggaatggc tgaaactgca
     1261 caaaggtatg agacttttgc caaggtactt actaaaaatg gttatatagt atatatcaat
     1321 gaccatagag gtcatggaaa aactgcaaag ataatagaaa atgttggaca tttagctgaa
     1381 aaagaaggat ttagatgtct tgtagaggac atgtatactt taacaaatat tataaagaaa
     1441 gaaaatgaag atttgccaat ttatctattt ggacacagca tgggttcatt tgcaagtcaa
     1501 agatatataa tggattacag taataattta tctggtctta tactatgtgg ttcaaatgga
     1561 aagcaaggaa tcattctaaa tcttgctcat ctgataatca atcgtgagat taaaaagtat
     1621 ggaagacgtt ctaaaagtaa taaaataaat aatttgatat ttggtggcga aataataaga
     1681 agaaatgaaa agactaagtt tgactggtta agtagagata aagaacaagt tgaaaaatat
     1741 ataaatgacc cattttgtgg agtagtgtgt agttgtggct ttttttatga tttagttcaa
     1801 gggttaaaag aaattgagga taaagaaaac ttaaaaaaag tgccacttga tatacctatt
     1861 tacataatat ctggagataa agaccccata ggaaaaaatg gtaaaggagt cttaagacta
     1921 agggatagat atataaaatt aggagtaaaa gatgtaactt gcaaacttta caaagatgga
     1981 aggcatgaat tgttgaatga aataaataga gaagaagttt ttgaggatat aatttgttgg
     2041 ttaaataata aaatagaaat attgtaataa aaaaatataa tgatatattt gctttaaatt
     2101 tatttatata taatatttga aaagtggatt atgtatatgc aaagtagaaa agagagagcc
     2161 tagaagtgat tttttgctat aatgccattt attgaatagg tgggtgttat tataaataaa
     2221 ttattaacac tcagtatgat tatcattgta tatggaattt attttattta aaattccttg
     2281 aaagtttaaa tatagtaagt tgtaataaag agaaaatcta aatatttaaa tgctatttaa
     2341 tgtgaatcta ttaattaggt tatacttaaa cttaattaat agattttata tttcaagcca
     2401 atgagatagg gttttagatt aaaatataac caatggttaa attacagaca ttttgttaac
     2461 tttccctcga tttactagta aatatttttt ttatatactt aaattacaac agatgtacta
     2521 gggaggtata tatgcaaatt aaaataggta aagtcataca gtgtcttaga aaagaacgaa
     2581 atttaactca agaacaatta gcaaagttta taggtgtgtc aacaccagca gtatctaagt
     2641 gggagagtgg aaattcttac ccagatatag aattattgcc tttattagca gactttttta
     2701 atgtgtctat tgataagctt ttaaattaca agattgattt aagtgaagaa gaagtaatga
     2761 aaatttataa agaattagaa tcaggctttg ctagaattga aattgattta tcaacagaag
     2821 aaccaaaaga agaatttaga caagacttag aatctgtaaa aaagctttcc aatatgtata
     2881 tagagaagta tcctaaaagc tatttattga agctaaggat atgttcgctg tatcagatgt
     2941 attcatataa atttggtaag agtgaactta atgacagagt aaaagaaaca atgaatattc
     3001 ttgaagatat agtgagaaat acagatgata tccaaataaa agaaacagct cttattatat
     3061 tatcaaacgc atattgtatg ttggaggatt atgaaaaggc agagttgtat ttaaatatga
     3121 tacataagtc aataggggat acaagtgtta atttagctat gatatattta aagcaaaata
     3181 gacttgaaga agcagaaata ttgcttcaaa ataaattgtt tagtaatgta tttaatataa
     3241 gcatggattg taagggaata attaatgtat acaaaaatca atacaaggaa ttaaagaaaa
     3301 aattggagaa tagaaatttt aataaaaatg caattgagag agaaatggag tatataaaaa
     3361 ataagttgct ggggtatgca aatctttctt tagaaataaa aaaaatgctc agtgaagata
     3421 aaggtgcatt ttttagtatg tatatggatt atatggaatt atctctaatt tttttatttt
     3481 ttaacatgaa agaagaagca aaaaaagcct tatatagtct aaaagaaata ttagaaaaat
     3541 atcctataca tgaaagtttg gatgtaagtc aaatgagatt ttttgataag gtagagtcta
     3601 aaaatttata tacttttaat atatatacaa acttgttaat tgtacttaat gatgatagtt
     3661 ataatgagct tagagaagaa ccaattttta aggatgtaat tgaaaagatt ttagatatgg
     3721 aaaaaatgtt gaaaaataaa gaataagtaa aaatttaata taggacttaa agattaatca
     3781 aattaaaaga aagtgtttca aaataaaaat ttgaatcacc ttttttgtcg gtcttaaaca
     3841 gttatttaga aaaatagagg tttcaaaata gaaatctgaa ttatctgtat tattacacaa
     3901 aaatagaaac ctaaatttat aaaaatagaa taaagtttgt tatataaaat gtaattttgt
     3961 ctataaaatc tcacttgttt tcttaacttt aagcgtgaaa aagagaatgt atcatgaatt
     4021 ttttagttca tgatgcatcc ttctttgtat gaaatccaat atatctttat tatttaaaca
     4081 atggaaaaga gccttatttc tattttgaga catctctttt atttaattat gaagttttat
     4141 acagttcaat aaataggaat tatatttaga aactcatgac attatttctt agatagtgat
     4201 taaatttatc atattccatt ttagataact tttctgggta agacattaca atcaggttat
     4261 gcccattaaa tttttcatgg tatggtggat gaatgtgttc ataattattt gtcttatatt
     4321 ttactctttc atagaacgcc ttgcgataaa ttgaaatctc atcaattgga aggtcaattt
     4381 ctaaaataat agtttttcct ttcttattta aaagctctaa cgctctttgt ccatatctat
     4441 tattgcgcat ttctggaaaa atgcagaaat gttctacata gataaagtca tctgtttccc
     4501 aacataaaat tatgccgaca aactggtttt tatcataaat taaattgaac tgatattctt
     4561 tatttttcaa aatttcttct tgcaaagaag attttctttg ttcatgaaat gggaaactaa
     4621 ttttatataa ttccatagcc ttgtaacata atttattttc actggttctt aaccgtttaa
     4681 atttcacttt actcctccta atcacgaaaa ttccaattta tttatgagtt cattttacca
     4741 tagtcagtat ttgcatacaa tgtgttttaa gttgagtgtc atttctttct tttatttatg
     4801 cttatatctc atagactaag agataattgc ttaagacata actaaaaact attatattaa
     4861 gctttgataa tctaaaaaca gtatatttat ggacttttct aggtctaaaa gtaatcttaa
     4921 taattttaga agttacaaaa aagttacata aatttggaaa gctataatat acatatataa
     4981 tataaggtta aaactgtaat gaataatatt aatttaaaat ttgaacatgg aaggagatta
     5041 ttatggagaa aagagaaaag aggataataa tatcatcttt attaagtgta tcaattttaa
     5101 tgggtttggt aagtatatat tctatattaa ataaagaaga cataatttta actgttaagg
     5161 gtcaagagca aaaagtatct tcctttaaga aaacagttga ggaacttttg gatgaacagg
     5221 gtataaagta taattctgaa gataagatta atccaagttt agatacagaa ctaaaagatg
     5281 atatgaaaat aaaagttgtt aaggtaacta aaagtaaaaa agaagagatt gaaaaaattc
     5341 catttgatac aaagcatgta aatgatagta atttgttaaa aggaaaatct aaagtttatc
     5401 aagaaggtca agaaggagaa aaaaaactag tctataattt aacttaccat gatggaaagt
     5461 tagtcaaaaa agtcttatca aaagaagtaa tatctaagga gccaactaca aaaattataa
     5521 aatatggaac taaagaaaaa gtactaatag catcaagagg agcaaatata agaggaggca
     5581 aacatatgaa agtggttgcc actgcatatg caggagatac aataacatct actggtacaa
     5641 ctccaagatg gggtgttatt gcagttgacc cacgtgtaat accatatgga acaaaagtat
     5701 atatacctaa actgggtatg acttttgtag cagaagattg tggaggtgca attaaaggta
     5761 atagaataga catttttatg aacagtgaag gaaaagcttc aaattgggga aggaaaagta
     5821 tagatatata tctacattaa attagtgaat agaataactt tacttgaagg acaaaaaagt
     5881 ataaaatatg aattaactaa actgttagat tattcttaaa acataaaaat atatctaagg
     5941 ggggataaga tgaaaatagt atgcttagga gacagtttaa cgtatggatt tggagtatca
     6001 cgaagtaatt catggacaaa cattgtaaat aaagagactc gattagaaat agtaaataag
     6061 ggtataaatg gtgatacaac aagtggtatg ttagctaggt ttaatgaaga tgttgtaaaa
     6121 aattctcctg atatagtttt tataatgggt ggcaccaatg attttattgc tggtgcggga
     6181 aatgaaatta ttaattctaa tataatggct atggtgcatc agtcatattc aaaaaatatt
     6241 atacctataa taggtatacc attaaaacca gatattccaa atgttaggga agattggagt
     6301 tgttttactg attttaatat agtatctcaa aacttagaat catatagtta ttggataaaa
     6361 aaattttgta tgacatttaa tactaatttc gtagattttt attcagaata taataaaaat
     6421 atggaactag aaggatataa aaaattatat tttgatgggt tacatccaac caaagagggt
     6481 catagaataa tggcagacat ttttattaat tcaattaata agtatataga agagttatag
     6541 attacattaa aatgcttgtt tatgcgtcag ttgcaataaa tacatacagt agagaggggt
     6601 ttattatgga ttatactaaa acttatgaag agtggataaa gggttcatat tttgatgaag
     6661 atacaaagct agagttggag aatataaaaa ataatgaaaa agaaatagag gatagattct
     6721 ataaggattt agaatttggg actgcgggtc ttagaggaat aattgaagca ggaacgaata
     6781 gaataaataa gtacacagtt agaagagcta cttttggatt ggcaaactat atattagaaa
     6841 acacaacaaa agaagaaaca agtagaggag tagtaatagc tcatgataat agacacaagt
     6901 ctagacaatt ctgtatagaa tctgcaaata ctttggcagc atgtggtata aaagcatata
     6961 tatttgatag tttgagaact actccagaat tatcttttgc tgttagaagc ttaaatgcaa
     7021 tcgctggtat agtcataaca gcaagccata atcctccaga atataatgga tataaggtat
     7081 actgggaaga tggagcacaa gttatgccag agattgcaaa tgcaataaca gagaaagtaa
     7141 atagtataca tgattatagt acaataccaa ccttaacgga agctaataaa aatttggtag
     7201 ttttgttgga cgaatcacaa gatactaaat ttatagaagc agtgaaaagc caaattataa
     7261 gaaaagattt agttaaaaat gtaggtaaaa gctttaagat agtttataca cctctttgtg
     7321 gaacagggaa tgttccaata agaagagcat tgaaagaagt tggttttgaa aatataattg
     7381 tagttccaga agaagaaaat ccagacccaa attttgcagg gcttgattat ccaaatccag
     7441 aagagaaaaa agctttaaat agaggtatat tactcgcaaa agaaaaagga gcagaccttg
     7501 taatagcaac tgacccagat tgtgatagag taggtgtagc agtaaaaact actacaggtg
     7561 agtatgcttt acttacagga aatcaaattg gtggtatgct gacacattat ataatagaag
     7621 gattaaaaga aaataataaa ttaaaagaaa atcctacaat aataaaaacc atagttacat
     7681 cagaatttgg agcagatata gctaaagcaa ataatgttga tgtattaaat gttcttacag
     7741 gttttaaatt tattggtgaa aaaataaaat tatttgaaca aaataaaaat agaagttatg
     7801 tatttggata tgaagaaagt tatggttact tagttgggac tcatgctaga gataaagatg
     7861 gtgtagtttc ttcattgtta atatctgaaa tggcagcatt ttactattca aaaggtatga
     7921 gtttatatga tggtttaata gaactttata aaaagtatgg atttttcaaa gaacagacta
     7981 tatctttgac tttaaaaggt atagaaggtg tagaaaagat aaaagaaata atatcttatt
     8041 ttagagaaaa tcaaattgat tatataaata gtattaaagt agttgataaa aaagattata
     8101 aaaatggtat agataatctt cctaaatctg atgttttaaa atactttttg gaagatgaat
     8161 cttgggtagc tataagacca tctggaacag aaccaaaact taaattttac atagctgtaa
     8221 aaggagctag tgatattgaa gcagataaaa agattcaagg tttgaaaaag tatatagatg
     8281 acatggtcga aaaattaaaa taaaatatta ttattttata agataatttt gtaataatat
     8341 ttatttagct gaaaattata atttactttc attgagtaga atatggaaat gttagtagaa
     8401 ttgttatttt cagcttttat ttgtgttatt tttacttaaa taattatatt atagaatgaa
     8461 tctgagtata attaatattg tataatgaaa ttaatttgat agaaaagggg atatttatgt
     8521 ttggtataga taagaaattg attgaatata taattgcaaa atccaattac agtgaattaa
     8581 gttcaaagtc agcagaagta tctttcttct taatgttgtc catatttcct tttttaatat
     8641 ttacaataag ttctatagct tatataccga ttcttcattt aaataagtat atagctttgt
     8701 ttagaaatat gatgccagaa ggtgcttttg ctgtgttatc ttcaatcata gtttctgcaa
     8761 tagacaatag aaacctgaaa tttttagcag tcagttttgt acttactatg tggacatttt
     8821 caagagcagt aaaagctctt attaaaggaa tgaatagagc ctataaagtt aaagaaacta
     8881 ggtctttttt taaaatttta tctatatcat ttttatttac aataatgctt ttggtcctta
     8941 tttttttatc tatgatattt ttagtttacg gtgaaaaaat aggttatttt atttttaatc
     9001 ttgtaggatt ggatgagata tttataaaaa tatgggatat tctaagatac actgtaggta
     9061 taataacaat aatagtgata tttacacttt tatataaata cactccaaat aaaaagttaa
     9121 ctattaaaga atctgcgcca ggtgctattt ttgctacttt tgcttggttt ttagtatcat
     9181 ttttatattc ttattataca aattactatg ctaactatga agtaatctat ggaagtatag
     9241 ctgaaataat tgtacttatg acctggatgt attttagtag ttggtctatc gttattggct
     9301 atgaggtaaa ttcaagattg tattttagaa agataagaca tgaaatgtta aagtaaagta
     9361 tttaaaataa aagagagtat ttagtattat aaatgtaatt gaattaataa agaaatattg
     9421 acatttaagt taaaaagtct agaatttttc tgggcttttt ttatttttag tataacttga
     9481 caaattttat ttaatgggat agttttaatt tataatcatc tttaaaaaga tgactattga
     9541 taagtaagag ataaaattgg taagtatcaa aaaatatact aaataaaaat tatagtccta
     9601 atgagttaat ttctgtattt tcaaataatg cagtatttag tcatgtgttt ttatatgcgc
     9661 ctgtatttct aattagcaat atattagaat aagctactgt aattagattt agaaaaaagc
//
LOCUS       DAEPID010000112         9584 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.113, whole genome shotgun sequence.
ACCESSION   DAEPID010000112 DAEPID010000000
VERSION     DAEPID010000112.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 9584)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 9584)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..9584
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.113"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            491..1696
                     /locus_tag="KR257_003433"
     CDS             491..1696
                     /locus_tag="KR257_003433"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426064.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyl transferase"
                     /protein_id="HBH0032096.1"
                     /translation="MSKKVLIMSASTGGGHNRAALAIKEELTSKTLDGEPIECEIIDS
                     LKLVNNTMDKIISRGYEKSAIYTPKAYGSVYRLSETNLLSKNEFKDNLLITFMAKKFK
                     KLIRSEKPDLIIGTHPFPMIALSTLKKNFNLHNNESNAYTEHFYKHYTNTINVPPLIS
                     VLTDYTTHSTWIQNEIDYYIVGHEYVKELLVFDGVEPSKIRTFGIPVEKSFLSHRDKD
                     IVLSELNLSPDKLTVLLMGGSFGAGNIKETLDELLDTDRDFQILVITGKNESLKEKIE
                     KKLMSRYHDKNVCVLGYTDKMNDILASIDVLVSKPGGLTTTEALLKDVPMIVPYYIPG
                     QEEENLDFLSNCGAALRTTKKYNLSILLKVLIDDPSRLEMLKRNIKSIRKSNSAQNIA
                     NLILNIISG"
     gene            complement(1767..1988)
                     /locus_tag="KR257_003434"
     CDS             complement(1767..1988)
                     /locus_tag="KR257_003434"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421616.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0032097.1"
                     /translation="MKPIMNLEEHNAMKEKRVKKMKSKDKPKYDDFEDISFSNKKKTK
                     KNVRNKNAEFRNNYKNYQYDYEEDFYEPI"
     gene            complement(2129..2728)
                     /gene="recR"
                     /locus_tag="KR257_003435"
     CDS             complement(2129..2728)
                     /gene="recR"
                     /locus_tag="KR257_003435"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012634696.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombination protein RecR"
                     /protein_id="HBH0032098.1"
                     /translation="MQVYTGPITRLIEEFSKLPGVGRKTAQRLAFHIINMNTNDVEAL
                     SKAIIDAKREIRYCSICCNITDTDPCSMCSNKSRDSSVICVVEDPRDVAAMERTREFK
                     GQYHVLNGVISPMDGIGPDMLKIKELIQRLGNQEVKEIIMATNPTIEGEATAMYIARL
                     VKPMGIKVTRIAHGLPVGGDLEYADEVTISKALEGRREI"
     gene            complement(2741..3091)
                     /locus_tag="KR257_003436"
     CDS             complement(2741..3091)
                     /locus_tag="KR257_003436"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009887752.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YbaB/EbfC family nucleoid-associated protein"
                     /protein_id="HBH0032099.1"
                     /translation="MAKKGFGGGMMPGGGNMNNLLKQAQKMQENMQKAQQELESKEVE
                     ASVGGGAVTVKVNGKKEVIDITIKPEVVDPDDIEMLQDLVLSAVNQALRNIDDIQASQ
                     MSKVTGGMNIPGLF"
     gene            complement(3150..4787)
                     /gene="dnaX"
                     /locus_tag="KR257_003437"
     CDS             complement(3150..4787)
                     /gene="dnaX"
                     /locus_tag="KR257_003437"
                     /EC_number="2.7.7.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421622.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA polymerase III subunit gamma/tau"
                     /protein_id="HBH0032100.1"
                     /translation="MHKALYRAYRPQKFEDVIGQDHIIKTLKNQIYSDNIGHAYLFCG
                     TRGTGKTSTAKIFSRAVNCLNKINEEPCNECEICESVLKDNTMDVVEIDAASNNSVDD
                     IRELRESVKYSPANAKYKVYIIDEVHMLSQGAFNALLKTLEEPPSYVIFILATTEPHK
                     IPATILSRCQRYDFKRVTVKDMTLRMKKICEDEGIDIDDKALNLIARNSQGALRDALS
                     ILDQCMSFGESKIDYKDVVELMGSVNIEQLFELSQCIVEQDTKKSLEILNEFVLWGKD
                     IRNLINDLIDHFRNLMVCKVSSELDEIISLPEETIEQLKIQSKNIDINDLIRILNILS
                     ITQDDIKSSSNPRVLVEITIMKIAQPMFDESKEALIKRVENLEKMIELGNFKSEKIGN
                     NKEKEYEVDREIDVKQENVVYEDVKNEDVILIESSWKNILKQIKKDKKMPIYALLSEV
                     KSFNVYSNMLYVIFDDKFDFAKTRLSSQDTINYLEKTIRDVLNRSFNVKIVLTSEVKD
                     INLEVKEKKDIGEEILKNIVSEEILEIKDSIDENESK"
     gene            complement(4864..5128)
                     /gene="ffs"
                     /locus_tag="KR257_003438"
     ncRNA           complement(4864..5128)
                     /ncRNA_class="SRP_RNA"
                     /gene="ffs"
                     /locus_tag="KR257_003438"
                     /product="signal recognition particle sRNA large type"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF01854"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: cmsearch."
                     /db_xref="RFAM:RF01854"
     gene            complement(5166..5257)
                     /locus_tag="KR257_003439"
     tRNA            complement(5166..5257)
                     /locus_tag="KR257_003439"
                     /product="tRNA-Ser"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:complement(5221..5223),aa:Ser,seq:gga)
     gene            complement(5258..5713)
                     /locus_tag="KR257_003440"
     CDS             complement(5258..5713)
                     /locus_tag="KR257_003440"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421624.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nucleoside deaminase"
                     /protein_id="HBH0032101.1"
                     /translation="MESSFYMKEALKEAYKAYNKKETPIGAIIVKDNQIIARAHNLTE
                     TLKDSTAHAEILAIKQASEKLGGWRLTDCDLYVTMEPCIMCSGAIVNSRIKKLIIGTR
                     HVKNSYIEKQHEFKLDYFNNNNVKVAFDVLQEECSIILQEFFKALRKRD"
     gene            complement(6034..7305)
                     /gene="serS"
                     /locus_tag="KR257_003441"
     CDS             complement(6034..7305)
                     /gene="serS"
                     /locus_tag="KR257_003441"
                     /EC_number="6.1.1.11"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000884181.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="serine--tRNA ligase"
                     /protein_id="HBH0032102.1"
                     /translation="MLDIKRIRENLDDIKKAMERRGEREFDLDAVVELDNKRREILQE
                     VEVMKNELNVNSKKIPQLIKEGKDVTEEKARLKELSDKIKGIDEKVKEVEAKMEYTLM
                     RIPNVPHPEVPQGETDEDNVQIRTWGEPTKFDFEHKAHWDIGTGLGILDFERAGKITG
                     SRFTLYRGLGARLERSLMNFFLNTHTAKHGYTEVLPPFMANRNSFIGTGQLPKFEEDM
                     FKIEGLEYFLIPTAEVPVTNIHANEILDVAELPIKYCAYTPCFRSEAGSAGRDTRGLV
                     RQHQFNKVELVKFVKPEDSYNELESLTHDAETMLQMLGLPYRVVKICTGDLGFTAAFK
                     YDLEVWMPSYNRYVEISSCSNFEDFQARRAGIRFKRDKKSKAEYVHTLNGSGLAIGRC
                     LAAILENYQQADGSVVVPEELRPYMGVDVIK"
     misc_binding    complement(7431..7636)
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00230"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="T-box leader; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /bound_moiety="tRNA"
                     /db_xref="RFAM:RF00230"
     gene            complement(7764..8645)
                     /locus_tag="KR257_003442"
     CDS             complement(7764..8645)
                     /locus_tag="KR257_003442"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421629.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="mechanosensitive ion channel"
                     /protein_id="HBH0032103.1"
                     /translation="MNFLSLAKTASTNSNITKRTLENMLDNFSDNIPNIIYAIIVFVI
                     GIYISKIVRRMVSKFLIKYGMSKGVNNFIVYGIYISMLSIISLISLGIIGIQTTSVVA
                     VLGAAGFSIGLAFKEILSNLGSGMIILFFKPFNIGDYIQGSGVEGTVSDIQIFSTVLK
                     TPDNKTIIIPNFQLTSNNIINYTHQNKRRIDFSYNISYDSDIDVVKSILNEIFTNEKR
                     ILNDPKPIIGLNSIGNNTMQIVARPWVKTDDYWDVYFDVMEKVKNKFDENDIKVPFVP
                     SSLLFNNTGNLNTMDKR"
     gene            complement(8657..9166)
                     /locus_tag="KR257_003443"
     CDS             complement(8657..9166)
                     /locus_tag="KR257_003443"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421631.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcription repressor NadR"
                     /protein_id="HBH0032104.1"
                     /translation="MNSNERRSKLIDILKESKHPVKGGTLAELLNVSRQVIVQDIALI
                     RARGFEIIATPQGYIIYNQPYFTKQIKCKNHKDSKEIYDELKIIVDLGGIIKDVIVNH
                     PTYGQITAELNIYSKMDIDNFMKKVETNEFKQLSVLTECSHIHTIEAIKEETIEAIVK
                     ELKDNGILS"
     gene            complement(9292..9408)
                     /gene="rrf"
                     /locus_tag="KR257_003444"
     rRNA            complement(9292..9408)
                     /gene="rrf"
                     /locus_tag="KR257_003444"
                     /product="5S ribosomal RNA"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00001"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: cmsearch."
                     /db_xref="RFAM:RF00001"
BASE COUNT         3057 a         1678 c         1030 g         3819 t
ORIGIN      
        1 ctcagatact attgttatca aaatatctgg ctttatggtt tgtttcttaa tataaattaa
       61 cctactgttt aattttcaat gttcgtgttt atttcttttt ccttttttca aggacaagta
      121 atactatatc atctttatct attctagtca atataatttt ttactttttt taattttttt
      181 atttatcatg tattctttat ctttaatttt taaaacttaa tgctaagtaa acctgtttat
      241 ttcataaaac taatatatat tctatgctct attttccttt ttattctata tttaaatttt
      301 ttatttacaa gaatattttt aatataacat atttgataaa attaatttac atttctttca
      361 cttgtaattt ttgcaatctt gtattagatt aatattaaaa ataatttatc aataacctta
      421 ttcacaaaga cagtttttat atatcaaaat ataatataaa tactatgcta cattttagga
      481 ggattttatt atgagcaaaa aagtattaat aatgtctgct tccactggtg gtgggcataa
      541 tagggctgct ctagctatta aagaagaact tacttccaaa acacttgatg gagagccaat
      601 tgaatgtgaa ataatagata gtttgaaatt agttaataat acaatggata aaataatttc
      661 aagaggatac gaaaaatctg ctatatatac tcccaaagcc tatggaagtg tatatagatt
      721 atctgaaaca aatcttttgt caaaaaatga atttaaagat aatctactaa taacattcat
      781 ggctaaaaaa tttaaaaagc ttattagaag cgaaaaacca gacttgatta taggaacgca
      841 tccttttcca atgattgctc taagtacatt gaaaaaaaac tttaatttac ataataatga
      901 atcaaatgct tacacagagc atttttataa acattataca aataccatta atgttcctcc
      961 gcttatttct gtattaaccg attatactac tcattctaca tggatacaaa atgaaattga
     1021 ttactatatt gttggtcatg aatatgtaaa agaattattg gtgtttgatg gagttgaacc
     1081 gagtaaaatt agaacatttg gaatccctgt tgaaaaatct tttctctctc acagagataa
     1141 agatattgtt ctttctgagt tgaatttatc tcctgataaa ttaactgttt tacttatggg
     1201 gggtagcttt ggggctggaa atataaaaga gacacttgat gaattactgg atactgatag
     1261 agactttcaa atacttgtaa ttactggtaa gaatgaaagc ctaaaagaaa aaatcgaaaa
     1321 aaaacttatg tctcgttatc atgataaaaa tgtatgtgtc cttggataca ctgataagat
     1381 gaatgatatt ttagcttcta tagatgtatt agtaagcaaa cctggtggac ttactacaac
     1441 tgaggctctt ttaaaagatg tacctatgat agttccttat tatataccag gtcaggaaga
     1501 agagaatctt gatttcttat ctaattgtgg tgcagcactt agaactacaa aaaaatataa
     1561 cttgtcaata ttactaaaag ttttaataga tgaccctagc agattagaaa tgctaaaaag
     1621 aaatattaaa tcaataagaa agtcaaattc agcccaaaat atagctaatt taattttaaa
     1681 tataatttct ggttgataaa ataaataaaa tccctatagt atatatatta tctattaggg
     1741 attttttatt ttctaattat ttaatattaa attggctcat aaaagtcttc ttcataatca
     1801 tactgataat ttttataatt atttctaaat tcagcatttt tatttcgtac atttttttta
     1861 gtttttttct tattagaaaa acttatatcc tcaaaatcat catatttagg tttatctttt
     1921 gatttcattt ttttaactct tttttctttc attgcattat gttcttctaa gttcataatt
     1981 ggtttcatgt tgcaccccta tcaaaatttt taaatgattt atacaacaaa ttatacaata
     2041 cagaagaaat ttattcaata aatctaaatc aaaattaatt tgaatttaac tcaaaaaact
     2101 acaaaaatcg aggtattaac ctcgattttt atatttctct tctgccttct agtgcttttg
     2161 atattgtgac ctcatctgca tactctaaat cgcctccaac aggaagacca tgagctatcc
     2221 gagtgacttt gattcccatt ggttttacta acctagcaat atacatggct gtagcttcac
     2281 cttcaatagt aggatttgtt gccattatta tttctttgac ttcctgattg ccaagtcttt
     2341 ggataagttc ctttattttt aacatatctg gtccaattcc atccattgga gaaattactc
     2401 catttaatac atgatactgt cctttaaact ctctcgttct ctccatagct gctacatctc
     2461 ttggatcttc cacaacacat ataacacttg aatctctact tttatttgaa cacatgctac
     2521 atgggtctgt atctgttata ttacaacaaa ttgagcaata tcttatttct ctttttgcat
     2581 ctataatcgc tttagataaa gcttccacat cattagtatt catattaata atatgaaaag
     2641 ccaatctttg agcagtcttt cttcctactc caggaagctt tgaaaattcc tctataagtc
     2701 tcgttatggg acctgtataa acttgcataa ataccaccta ctagaataac ccaggtatat
     2761 tcatacctcc agttacctta ctcatttgac ttgcttgtat atcatcaata tttctcaatg
     2821 cttgatttac tgcacttaaa actaaatctt gtagcatttc tatatcatct ggatcaacta
     2881 cttctggctt gatagttata tctataactt cttttttacc attaactttt acagtaactg
     2941 ctcctccacc aactgaagct tctacttctt tactttctaa ctcttgttga gctttttgca
     3001 tattttcttg cattttttga gcctgcttta acaagttgtt catatttcca ccaccaggca
     3061 tcattccgcc tccaaaacct tttttagcca taaacactat tcctcctaaa cttattttca
     3121 ttttattatt atatcataat agtattttat tatttactct cattttcatc aatactatct
     3181 tttatttcta atatctcttc actcactatg ttctttaata tttcctcacc aatgtccttt
     3241 ttctctttaa cttcaagatt tatatcttta acttctgatg tcagtactat ttttacatta
     3301 aaacttctat ttaaaacatc tcttattgtt ttttctaaat aatttattgt atcttgagag
     3361 ctcagtctag tttttgcaaa atcaaattta tcatcaaata taacatacaa catattagaa
     3421 tatacattaa aactttttac ttcacttaag agtgcgtata ttggcatttt tttatctttt
     3481 ttaatttgtt taagtatatt cttccaagat gactctataa gtataacatc ctcatttttt
     3541 acatcttcat aaactacatt ttcttgtttt acatctattt ctctatcgac ctcatactct
     3601 ttttctttat tattcccaat tttttcagac ttaaagttcc ccagttcaat cattttttct
     3661 aagttctcaa ctctttttat aagagcttct ttactttcat caaacattgg ttgagcaatt
     3721 ttcattatgg ttatttccac taaaaccctt ggatttgaag atgactttat atcatcctga
     3781 gttattgata atatatttaa aatccttatt aaatcattta tatctatatt tttagactga
     3841 attttaagtt gttctatagt ttcttctggt aatgaaatta tttcatccaa ttctgatgaa
     3901 accttacata ccattaaatt tctaaaatga tcaattaagt catttataag atttcttata
     3961 tctttgcccc ataagacaaa ttcatttaat atctcaagag actttttagt gtcctgctct
     4021 acaatacatt gagacaattc aaataattgt tctatattta cgcttcccat taattcaaca
     4081 acatctttat aatctatctt actttctcca aaagacatac attggtctaa tatactaagt
     4141 gcatctctaa gagctccttg agaatttcta gctattaaat taagagcttt atcatctata
     4201 tcaattcctt catcttcaca aatctttttc attctaaggg tcatatcttt aactgtaact
     4261 cttttaaaat cgtatctttg gcatcttgat aaaatggttg caggtatttt gtgaggctct
     4321 gtagttgcta atataaaaat tacatatgat ggaggttcct ctaaggtctt taataatgca
     4381 ttaaaagctc cttgagacaa catatgaact tcatctatta tatatacttt atatttagca
     4441 ttggctggag aatatttcac actttctcta agctctctta tatcatctac actattattt
     4501 gaagctgcat ctatttctac aacatccatt gtattatctt ttaatacaga ttcgcatatc
     4561 tcacactcat tacacggttc ttcatttatt ttattcaaac agtttactgc tcttgaaaaa
     4621 atctttgcag tagatgtttt accagtacct cttgttccac aaaacaaata agcatgtcct
     4681 atattatcac tatatatttg attctttaaa gtcttaataa tatgatcttg accaataaca
     4741 tcttcaaatt tttgtggtct atatgctcta tataatgctt tatgcatctt tttacctctc
     4801 tttagcaaaa ttaataaaaa aatccctcat tatctaaggg attagtcttt tatatattaa
     4861 atgctgtaca ccatctatcg acttaattcc ataggcgtta ccaaaacagt tagctcaact
     4921 taggcacccc cacggcacac aaaagtgatc acttaccgct gcttccttcc ggatctgacg
     4981 gggttcatga gctttcattg cgcaggacct aagcatcaac accacttatt tagggcggcc
     5041 ctacagaaaa taagccttta gatggaattc aatcctgcta tagcggattg caggttacag
     5101 ggcaccgcta cctccccatc tagtacagca aaattacaac catatttaat tactttcatt
     5161 gtttctggcg gagagagtgg gatttgaacc cacgatacag ttttacccat atactcgctt
     5221 tccaggcgag cgccttcgac cactcgacca tctctcctta atctcttttt ctcaatgcct
     5281 taaaaaattc ttgcaatatg atcgagcatt cttcttgcaa aacatcaaaa gctactttta
     5341 cattattatt attaaaataa tctaatttaa actcatgctg tttttctata tatgaatttt
     5401 ttacatgtct tgtccctatt ataagctttt ttattctaga attaactatt gcgccactac
     5461 acattatgca aggttccatt gtaacatata aatcacaatc agtcaacctc caaccaccta
     5521 atttttctga tgcttgtttt atcgctaaaa tttctgcatg tgccgtagag tcttttaacg
     5581 tttctgtaag gttatgagct ctagctatta tttgattatc tttaactata atagcaccta
     5641 ttggtgtttc ttttttatta tatgctttat atgcttcttt taatgcttct ttcatataaa
     5701 atgaactttc cataattcct cccaaaactt ataacaaact tatcttatca taattcattt
     5761 tataattcaa cttaatttta ttttgtttat ttaattatta ctatatatag ctatattttt
     5821 tttaaattag ttctaaaata atttttagat attcatacaa gagtgtttta taaaaatatt
     5881 tagtgtttta tgatgaaaat tctgctgtgt aaattaacat aaaaaaacta tgaaattaat
     5941 atttataata atttcatagt ttttttattt attgtttact cataatatat tctcttcatc
     6001 aaagcatact ctacatatac aattaatata aatttatttt ataacatcaa cacccatata
     6061 aggtcttaat tcttctggaa ctactacaga accatctgcc tgctgataat tttctaatat
     6121 agcagccaaa catcttccta tcgctaatcc agaaccattt aatgtatgaa catattctgc
     6181 ttttgatttt ttatcccttt taaatcttat tcctgctctt cttgcttgga aatcttcaaa
     6241 atttgaacaa gaagatattt ctacatatct attgtagctt ggcatccaaa cttctaaatc
     6301 atatttaaat gcagctgtaa atcccaaatc tcctgtacat atttttacaa ctctatatgg
     6361 aagacctaac atttgtaaca tagtttcagc atcatgagtt aatgattcta attcattata
     6421 agaatcttct ggtttaacaa atttaactaa ttcaacttta ttaaattgat gttgtctaac
     6481 taaacctctt gtatctcttc ctgctgaacc tgcttcagat ctaaaacaag gagtatatgc
     6541 acagtattta attggaagct ctgcaacatc taatatttca ttagcatgta tattagtaac
     6601 aggaacttca gctgttggta ttaagaaata ctctaatcct tctattttaa acatatcttc
     6661 ttcaaattta ggaagttgac cagtccctat aaaactattt ctattggcca taaatggagg
     6721 taagacttcc gtatagccat gcttagctgt atgagtattt aaaaagaaat tcattaaaga
     6781 tctttctaat ctagctccta atcccctata taaagtaaac cttgacccag ttattttccc
     6841 tgctctttca aaatctaaaa tacctagacc tgtacctata tcccaatgcg ctttatgctc
     6901 aaaatcaaat ttagtaggtt ctccccaagt tcttatttga acattgtctt catctgtttc
     6961 accttgtggt acctctggat gaggaacatt tggtattctc attaatgtat attccatttt
     7021 tgcttctact tcttttactt tctcatcaat accttttatc ttatctgata actctttcaa
     7081 tcttgccttt tcttctgtta catcttttcc ttcttttatt aattgaggta tttttttaga
     7141 atttacattt aactcatttt tcataacttc aacttcttga agtatttctc ttcttttatt
     7201 atctaattcc actacagcat caaggtcaaa ttctctttca cctcttcttt ccatagcttt
     7261 tttgatatca tctagatttt ctcttattct tttaatatct aacatattaa ttcctcctaa
     7321 taattttgat aatataagtt ataattccaa cttaatttac aaacattata cttgtaaact
     7381 cttagtttaa acaaatttta aaaataaaaa aagacctccg tttaccctat aaaagggacg
     7441 aaaatctttt atccgcgttg ccaccctaat tgactatact aaaatgtata atcctctcag
     7501 acctataacg taggtaaacg tctagcttta actagaagct ctagagtaga ttcaaaaacc
     7561 attgtaatga gttttcacca tccactcatt ctctgaatac aatctgtttt ttactatttt
     7621 ccttcacagc tttttaacta attgttttat ttgataatca ttatattata tatattaaca
     7681 tctttcaata ctattattca aattttttta gaattttctt taatttttta tattaaattc
     7741 attttttcta tttaattaag accttatctt ttatccattg tatttagatt acctgtatta
     7801 ttaaataata atgaagaagg aacaaatgga acttttatat cattctcatc aaatttattt
     7861 tttacctttt ccattacatc aaagtataca tcccagtaat catcagtttt tacccaaggt
     7921 ctagcaacta tttgcatggt gttatttcct atagagttta gacctattat aggctttgga
     7981 tcatttaata ttcttttttc gtttgtaaaa atttcattta atatagactt aactacatct
     8041 atatcactat catatgaaat attatatgaa aaatctattc ttcttttgtt ttgatgtgtg
     8101 taattaatta tattattact tgtcagttga aaattaggta taattatagt tttattatct
     8161 ggcgtcttaa gaacagtgct aaatatttgt atgtcagaaa ctgtaccttc tacacctgaa
     8221 ccttgaatat aatcacctat attaaatggc ttaaaaaata aaataatcat accagagcct
     8281 aaatttgata atatttcttt aaaagctaaa cctatactaa atccagcagc tcctaacaca
     8341 gctacaactg atgtagtttg tatccctata atacctaagc ttatcaatga tataatagat
     8401 aacatagata tatatattcc atatacaata aaattattta cacctttact cattccatat
     8461 ttgattagaa actttgaaac catccttctt actattttag atatataaat acctatcaca
     8521 aatacaatta ttgcatatat aatatttggt atattatcac taaaattatc gagcatattt
     8581 tctaaagttc tcttagttat attgctattt gttgaggcag tcttagccaa tgataaaaaa
     8641 ttcattcaac tcctccttat gataatattc cgttgtcctt taactctttt actatagctt
     8701 ctatagtttc ttcttttatt gcctcaattg tatgaatatg gctacattct gtcagaaccg
     8761 ataattgttt aaattcattt gtctcaactt tcttcataaa gttgtctata tccattttag
     8821 aataaatatt aagttctgca gttatctgac catatgttgg atgatttaca ataacatctt
     8881 ttataatacc acctaaatct acaattatct ttaattcatc ataaatttct ttagaatcct
     8941 tatgattttt acactttatt tgttttgtaa aatacggttg attatatatt atatatcctt
     9001 gaggtgtagc tattatttca aatcctctag ctcttataag ggctatatct tgaactatta
     9061 cttgcctact tacatttaat agttcagcta gtgttccacc ttttacagga tgcttagatt
     9121 cttttaaaat atctattaat ttacttcttc tttcattaga attcatatta caccttcttt
     9181 ccaaataaaa actttaccta tactatataa ttttatattt tatcttatta taaatcaata
     9241 ttgactttat attctattta atcttaactt ttataataaa taaaaaagac tacgtggcta
     9301 cgtcctactc tcccaggcag tttcccacca agtaccatca gcgctagaga gcttaacttc
     9361 tgtgttcgga atgggaacag gtgtatcctc tctgctattg taaccacata atctttatgc
     9421 ttaatatttc tattaagttt ttaataagtt tctagaatct agtaatacta gtttctttag
     9481 agttagcact ctaaaaacta cacatatatc ttaatgaatg aacatcaaat aaatattggt
     9541 caagtcctcg acctattagt atcgataagc taaatacatt gctg
//
LOCUS       DAEPID010000113         9397 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.114, whole genome shotgun sequence.
ACCESSION   DAEPID010000113 DAEPID010000000
VERSION     DAEPID010000113.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 9397)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 9397)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..9397
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.114"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            186..1550
                     /locus_tag="KR257_003445"
     CDS             186..1550
                     /locus_tag="KR257_003445"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423322.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="zinc ribbon domain-containing protein"
                     /protein_id="HBH0032105.1"
                     /translation="MGEKKINNMNYSHNNYSKKTGEPTRKIKNSHITLKSKEEKICSS
                     CNKENNTKDNYCKFCGNELYEIASLRPLETKLDLKSKIKELSYHANKRGVFLTTFTTI
                     FILFIIALIFKAIITIQFNDISYLVNPAHIILALNLGQISVSMSTMMGSGFINANIGL
                     LILLIIPILVLLISNLIFMRKRCRDSKTVLANSLGVGIFYGLVLAILSIFTNVKTSSH
                     SMLEYGYALEYSYEFFSVLLNGFVLGFICTYITTYKKSYEKENMYLSLFSNSIRTFIL
                     GYVLVLVILLVLTISDSSYLNELDMSSYSNGLNLFTILPQIASYMWAFANGISVTIIN
                     STVSMFTLSSSSLFGDTKLMFYAMGALSMLILLLNGYKLRFKYNTDSIRPIIVFSIYY
                     AFLMGILALFSTFILDSNINFFNTTNYGTTLIMQFKVLQAIVISFVYSFVISLIGYKL
                     NSAD"
     gene            1572..2063
                     /locus_tag="KR257_003446"
     CDS             1572..2063
                     /locus_tag="KR257_003446"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430450.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="zinc ribbon domain-containing protein"
                     /protein_id="HBH0032106.1"
                     /translation="MEGNTNNKVDDKFSKVKKKFGSGKFKVELYKEKSKLNREIDDIQ
                     EKKAKIFLEMGILTYQKIREDSINDNSFDKFCDELLELDKLIYEKNMEINEMEMAESN
                     VTCECGYVGNVNDKYCAECGKKFELENECDDFIICGYCESEIDTEAEFCPCCGRKIIM
                     DLE"
     gene            2335..3006
                     /locus_tag="KR257_003447"
     CDS             2335..3006
                     /locus_tag="KR257_003447"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003433825.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="N-acetylmannosamine-6-phosphate 2-epimerase"
                     /protein_id="HBH0032107.1"
                     /translation="MLDKVKGRLIVSCQALENEPLHSPFIMGRMAKAAMEGGAVGIRA
                     QGVEDIIEIKKVTGLPVIGIIKRNYEDSDIYITPTKKEVDELLTTGCEMIALDATNRV
                     RPNNEDLKELIKYIKENGVLVMADISNYDEAIKAQEYGVDCVSTTLSGYTPYTKTLEG
                     PDFVLMKRLVKDLEIPVIAEGKVNTPQDLKKVFELGVHSSVVGSAITRPQLITEKFVK
                     AIEIN"
     gene            3091..3957
                     /locus_tag="KR257_003448"
     CDS             3091..3957
                     /locus_tag="KR257_003448"
                     /EC_number="4.1.3.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003452648.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="N-acetylneuraminate lyase"
                     /protein_id="HBH0032108.1"
                     /translation="MKGIYSALLVSFDKEGNINEKGLRQIIRHNIDVCKVDGLYVGGS
                     TGENFMLSTDEKKRIFEIAKDEVKEEIKLIAQVGSVNLKEAVELAKFTTDLGYDAISA
                     VTPFYYKFDFEEIKHYYNTIINSVDNRLIIYSIPFLTGVDMSLDQFGELFENEKIIGV
                     KFTAADFYLLERMRKTFPNKLIFAGFDEMMLPATVLGVDGAIGSTFNVNGVRARQIFE
                     LTKNEKISEALEVQHVTNDLITDILGNGLYQTIKLLLEEQGVEAGYCRQPMKEATDEM
                     KSRAKEIYRKYF"
     gene            3990..5492
                     /locus_tag="KR257_003449"
     CDS             3990..5492
                     /locus_tag="KR257_003449"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003462875.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sodium:solute symporter"
                     /protein_id="HBH0032109.1"
                     /translation="MVGFTWIDFAILVVYLLAVLFAGLLFSKKEMKGKEFFKGDGTIP
                     WWVTSVSIFATLLSPISFLSLAGNSYGGTWILWFAQLGMFIAIPLTIKFFLPLYSRLE
                     IDTAYEYLEMRYESKGLRVLGALMFIIYQIGRMSIIMYLPSIVLAGLTGIPVNVLIIV
                     MGVIAIIYSYTGGLKAVLWTDFIQGMVLIVGVTGTLFYLIASINGGFGTVMDTLTTGH
                     KFLASNEVMFDKNILSTSAFIIFVGAGLNTFSSYVSSQDIVQRFTTTTDIKQLNKMTY
                     GNGVLSMGLATVFYLIGTCLFIYYTQNPDLAQTVQQDQVFASYIAYELPVGITGILLA
                     AIYAASQSTLSTGLNSVATSWTLDIQTIITKDISMEKQTKIAQYISLGVGILSIAVAI
                     VLANGEIKSAYEWFNSFMGLVLGVLAGIFVLGAFCKKATKMGAYVGFIVSAILVVYLK
                     YRMPEVTSWAYSLITITTSVVVGTIVSAIEAKVKAKVSLPKAETTVYYEK"
     gene            5622..6074
                     /locus_tag="KR257_003450"
     CDS             5622..6074
                     /locus_tag="KR257_003450"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890423.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YhcH/YjgK/YiaL family protein"
                     /protein_id="HBH0032110.1"
                     /translation="MIFGNINHSKTYSTLHEDLLRCFEYAKDNSLIDYEKGTYTIDGD
                     DIFVNIVEYKTCEKEDRFWEAHKKYIDVHLMLDGCERIDINFIENLEQKIYEEKGDFL
                     PLDGKNNGYMELRKGDFLVCYPEDAHMTGIKVLEKENIKKAIFKVLVR"
     gene            6234..7037
                     /locus_tag="KR257_003451"
     CDS             6234..7037
                     /locus_tag="KR257_003451"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003433827.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0032111.1"
                     /translation="MENIDVFLLIGQSNARGLGNPKESIIPNENCFEYLSTDEIINMR
                     CELETSEGDGTIAPAFSNEWNKLTGNKVCFIHNAKDGSRIKNWNHDNNWFLNDTIEKF
                     NTGCTTLSKHYNIENKYVIWIQGESDAKYGSDVLYYKESLKKIAYRLKEECMIDKMFV
                     SLTGYWLGEDEYFIRTRRIAAAQESACSECDILCVGSKIAMQFHDRGLTIDDVHYTQE
                     GLNMLGEDLCKNIYKYHITKEKSVLSDTIDLSEARKYICELEKISKRFV"
     gene            7095..7982
                     /locus_tag="KR257_003452"
     CDS             7095..7982
                     /locus_tag="KR257_003452"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423341.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ROK family protein"
                     /protein_id="HBH0032112.1"
                     /translation="MKNYVCIDVGGTSIKYGFIREDGFIIDKSSLDTEAKEKGGEGIL
                     AKIKDIVKKYIEENEISGICISTAGMVDPVEGKILFALEELIPNYKDMQLKKEVEKEF
                     NIKCEVENDVNCAGLGEMWLGAGRGATSSICLTIGTGIGGCIIINNKLINGFSNSAGE
                     VGYMNVNGSSFQELASTSSLIKKVAKIKNLNENDLNGKIIFDLAKNNDEDCLKELDNM
                     IKSLAVGIANICYVINPEVVILGGGIMAQEKFLKPKIDKALKEVLIERVYKNTNIEFA
                     KRQNDAGMLGALYNFLNKI"
     gene            8001..8849
                     /locus_tag="KR257_003453"
     CDS             8001..8849
                     /locus_tag="KR257_003453"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003433168.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MurR/RpiR family transcriptional regulator"
                     /protein_id="HBH0032113.1"
                     /translation="MSILEQLESPTFKVTKSDKLLIAYIKENIDDVFYKPISQIAKES
                     NIGEATITRFVKKMNFNGLQDFKVTLAQEISTINKKNIINKNIQNDEPALDTAKKLLS
                     SNVTTLENTVEIINSKDVHDCARLIINAKKVYFIGIGYSGIIAQDSNYKFMRIGLNCV
                     SFDSSHTMIMMSSIMEEGDLIIAISHSGETEEIIKTVKLARANNAKIISITENKNSEL
                     KDISDVHLSYVSGETVLETGSISSKLAQFFIIDLVYTQVVKELSNEAIERKIKTTNAI
                     KLFKNE"
     gene            8912..>9397
                     /locus_tag="KR257_003454"
     CDS             8912..>9397
                     /locus_tag="KR257_003454"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018112794.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Crp/Fnr family transcriptional regulator"
                     /protein_id="HBH0032114.1"
                     /translation="MSKLKDYNIDKVIIFNNLSTKTKNQLKEKVKLKRLQKKEILFYE
                     KDSLDSVYILLEGKVSIFKISENGERKVIFILNSGEVINDITLDASKNSTVGCEAFEN
                     SIVAYYSIEEFLEIMQNDFQLTKDIISYMERRIRRLYRQLKNSISIKVDKKLAAKLYR
                     LS"
BASE COUNT         3797 a          898 c         1641 g         3061 t
ORIGIN      
        1 attaagcata ataaaatata aataataaag ttcgcattaa caaactattt aaatatcaag
       61 acctgttaaa aaacaacagc aataaacaaa taaaatagat aaatatatcc aattaaggta
      121 taattaagtt ttatatgata tagttatatt tgataattta caatagtaaa acttggaggg
      181 aaaaaatggg tgaaaagaaa ataaataata tgaattattc acataataat tattccaaaa
      241 agacaggtga accaactaga aaaataaaaa atagccatat cactcttaaa agtaaagaag
      301 aaaaaatttg ttctagttgc aataaagaaa ataatactaa ggataattac tgtaaatttt
      361 gtggaaatga actttatgaa atagcatcat taagaccact tgaaacaaaa ctagacttga
      421 aatctaaaat aaaagagctt tcatatcatg caaataaaag aggtgtattt ttaacaacat
      481 ttacaaccat atttatattg tttattattg cattgatatt taaagctatt ataactattc
      541 aatttaatga tattagttat ttagtaaatc cagcacatat aatcctagct ctcaacttgg
      601 gtcaaattag tgtatctatg tctaccatga tgggttctgg gtttataaat gccaatatag
      661 gtttgttgat attacttata atccctattt tggtattatt aatatcaaac ctaattttta
      721 tgagaaaaag atgtagagat tcaaaaactg tattagcaaa ttctctagga gttggaattt
      781 tttatggatt agttttagct attttatcta tttttactaa tgtaaaaact agttcacata
      841 gtatgttaga atatggatat gcattagaat atagttatga attttttagt gttcttttaa
      901 atggattcgt attagggttt atatgtacat acataactac ttataaaaaa agttatgaaa
      961 aagaaaatat gtatttatct cttttttcaa attctataag aacattcata ttaggttatg
     1021 ttttagtatt agtaatacta ttggtactaa ctatatctga tagtagttac ttaaatgaac
     1081 tagatatgag tagttattca aatggattaa atttatttac tatactccca caaatagcta
     1141 gttatatgtg ggcttttgca aatggaattt cagtaaccat aataaactca acagtatcaa
     1201 tgtttacttt aagttcttca tctttatttg gagatactaa attaatgttt tatgcaatgg
     1261 gagcattgtc tatgttaata ttattattaa atggatacaa gctaagattt aagtataata
     1321 cagatagtat aagacctata atagtattta gtatatatta tgcatttttg atgggaatat
     1381 tggccttatt tagtacattt atactagata gtaatattaa tttctttaat acaactaatt
     1441 atggaacaac tttaataatg caatttaaag tcttacaagc tattgtaatt tcatttgtat
     1501 atagttttgt gatatcttta ataggatata agctaaattc agctgattaa atatgattgg
     1561 agggaatttc tgtggaagga aatactaata ataaagtaga tgataaattt tctaaggtta
     1621 agaaaaagtt tggtagtgga aaatttaaag ttgaattata taaagaaaaa tcaaaattaa
     1681 atagagagat tgatgatatt caagaaaaga aagcaaagat attcttggaa atgggaatac
     1741 tgacatatca aaaaattaga gaagattcta ttaatgataa tagttttgat aaattctgtg
     1801 atgagttact agaacttgat aagttaattt atgaaaaaaa tatggaaatt aatgaaatgg
     1861 aaatggcaga aagtaatgta acttgtgagt gtggttatgt tggaaatgta aatgataaat
     1921 attgtgctga atgtggtaaa aaatttgaat tggaaaatga atgtgatgat tttataattt
     1981 gtggttattg tgaaagtgag atagatacag aggctgaatt ttgtccatgc tgtggaagaa
     2041 aaattataat ggatttagaa taatattggg aaacctatgt atagtataca tgggtttttt
     2101 tattgaaatt atttaaatgg acttataaca gtagttatat aaaatgaaaa taaacaccaa
     2161 aaaaatgaaa taaaatttct tttaaatgta aaaaacaagc taatatataa aataaatcag
     2221 taaaaatata gatgcgagaa aaaatatgaa aaaatattgc aaagaaaaag ttttcatgtt
     2281 attattaata cataaatcaa gaaaataaat ttcagaaacg aggtaattta aaaaatgcta
     2341 gataaggtaa agggaagatt aatagtatca tgccaagctt tagaaaatga acctcttcat
     2401 agtcctttta taatggggag aatggctaag gctgctatgg aaggtggagc tgttggaatt
     2461 agagctcaag gagttgaaga tattattgaa ataaaaaaag ttactggact tcctgttata
     2521 ggtattataa agagaaacta tgaagattca gatatatata taacgccaac taaaaaagaa
     2581 gttgatgaac ttttaacaac agggtgtgaa atgatagcat tagatgctac caatagagtt
     2641 agaccaaata atgaagactt aaaagaactt ataaagtata taaaagaaaa cggtgttcta
     2701 gtaatggcag atatttcaaa ttatgatgag gctatcaaag cacaagagta cggtgtagat
     2761 tgcgtttcaa ctacactatc tggatatact ccatatacta aaacattaga aggtccagat
     2821 tttgtattaa tgaaaagatt agttaaagat ttagaaatac ctgtaatagc tgaaggaaag
     2881 gtaaatactc ctcaagattt aaaaaaggtc tttgagttgg gtgttcattc atcagtagta
     2941 ggttcagcaa taacaagacc acaattaata acagaaaaat ttgttaaagc aattgaaatt
     3001 aattaaaaat taatttataa attaaaaaat tattatattt aactatattt gaaaattaaa
     3061 attggaggta aagatatgag aacaacagat atgaagggaa tttattcagc attattagtt
     3121 tcatttgata aggaaggaaa tataaatgaa aaagggttaa gacaaataat tagacacaat
     3181 atagatgttt gtaaagtaga tggtctttat gtaggaggaa gtacagggga aaacttcatg
     3241 ctttcaactg atgaaaagaa aagaatattt gaaatagcta aagatgaagt gaaagaagaa
     3301 ataaaattaa tagctcaagt tggttcagtt aatttaaaag aagctgtaga acttgctaaa
     3361 tttacaactg atttaggata tgatgcaata agtgctgtta caccttttta ctataaattt
     3421 gattttgaag aaataaaaca ctattataat acaataataa attctgtaga taatagatta
     3481 ataatatact ctataccatt tttaactggt gttgatatga gtttagacca gtttggagaa
     3541 ttatttgaaa atgaaaaaat aataggtgtt aagtttacag cagcagattt ctacttatta
     3601 gagagaatga gaaaaacatt cccaaataaa ttaatatttg caggatttga tgaaatgatg
     3661 ttaccagcta cagttttagg tgtagatggg gcaattggtt ctacattcaa tgtaaacggt
     3721 gtcagagcta gacaaatatt cgaattaact aagaatgaaa aaatatcaga agcacttgaa
     3781 gtacaacatg tgactaatga tttaataaca gatatattag gaaatggctt atatcaaaca
     3841 attaaattac tacttgaaga acaaggtgtt gaggctggat actgtagaca acctatgaaa
     3901 gaagcaactg atgaaatgaa atcaagagca aaagaaatat acagaaagta tttttaataa
     3961 aatactttta gtatgggagg attagtcaaa tggtaggatt tacttggata gattttgcaa
     4021 tactagtggt ttacttattg gcagttttat ttgcaggatt gttattttca aaaaaggaaa
     4081 tgaagggaaa agagttcttc aaaggtgatg gaactattcc gtggtgggtt acatcagtat
     4141 caatatttgc cacattatta agtccaatat catttttatc attagcagga aattcttatg
     4201 gtggtacttg gattttgtgg tttgcacaat taggtatgtt tatagcaata cctttgacaa
     4261 taaaattttt cttacctcta tatagtaggt tagaaataga tacagcatat gaatacttag
     4321 aaatgagata cgaaagtaaa ggtcttagag tacttggagc tttgatgttt ataatatatc
     4381 aaataggacg tatgtctatt ataatgtatc ttccatcaat agttctggct ggtcttacag
     4441 gaatacctgt aaatgtactg ataatagtta tgggtgtaat agcaataatt tactcatata
     4501 caggtggatt aaaggctgtc ttgtggaccg attttataca aggaatggta ttaatagtag
     4561 gtgttacagg gacattgttc tatttaatag caagtataaa tggtggtttt ggaacagtaa
     4621 tggatactct tacaactgga cacaagttct tagcaagtaa tgaagttatg tttgataaaa
     4681 atatactatc tacaagtgca tttataatat ttgttggagc tggtcttaat actttttcat
     4741 catatgtatc gagtcaagat atagttcaaa ggtttactac aacaactgat ataaagcaac
     4801 ttaataaaat gacatatgga aatggtgttt tatcaatggg acttgcaaca gtattttatc
     4861 taattggaac ttgtttattt atatactata ctcaaaaccc agatttagct caaacagttc
     4921 aacaagacca agtatttgca tcatatatag cttatgaatt accagtgggt ataacaggaa
     4981 tactacttgc agcgatatat gcagcttctc aatcaacttt atcgacaggg cttaattcag
     5041 ttgctacaag ttggacttta gatatacaaa ctatcataac aaaagatata agtatggaaa
     5101 agcaaactaa gatagcacaa tatatatcat taggtgtagg tatactttct atagctgttg
     5161 caatagtatt agcaaatgga gaaataaagt cagcatatga atggttcaat agttttatgg
     5221 ggctagtact aggtgtttta gcaggaatat ttgtacttgg tgcattttgt aaaaaagcaa
     5281 ctaaaatggg agcatatgtt ggattcatag tatcagcaat tttagttgtt tatttaaaat
     5341 accgtatgcc agaagtaact tcttgggcat attctctaat aacaatcacg acttctgtag
     5401 tggtaggtac aatagttagt gcaatagaag ctaaagttaa agcaaaagta tctttaccaa
     5461 aagctgagac tactgtttat tatgaaaaat aatatttaaa tgataaattg tcttatagag
     5521 tgattagata aataatttag ttactctata agattgtata atatactttg tatacaaaag
     5581 tataaaaata gactttataa ttatataggg agatagtgct tatgatattt ggaaatataa
     5641 atcatagtaa gacatattca acattgcatg aagatttact tagatgtttt gaatatgcta
     5701 aagataattc attaatagat tatgaaaaag gtacttatac aatagatggt gatgatattt
     5761 ttgtgaatat tgtagagtat aaaacttgtg aaaaagaaga tagattctgg gaagctcata
     5821 agaagtatat agatgttcat ttgatgcttg atggatgtga acgaatagat ataaatttta
     5881 tagaaaattt agaacaaaaa atatatgaag aaaagggcga tttcttgcct cttgatggta
     5941 aaaataatgg atacatggaa cttagaaaag gtgatttttt agtttgttat ccggaagatg
     6001 ctcatatgac aggaataaaa gttttagaaa aagaaaatat caaaaaagct atttttaagg
     6061 ttttggttag ataatgataa tttatataac cactagggct gaaaatagtg atttaacttt
     6121 cagcgattag tgagacttcg taaattttag ttagattact attttcagcc ttagtttttt
     6181 atgagaaaat taaaaataat taaaagctta aaattttgta aaggagttaa cttatggaaa
     6241 atatagatgt attcttatta ataggacaaa gcaatgctag aggattggga aatccaaaag
     6301 agagcatcat tccaaatgaa aattgttttg aatatttgag tactgatgaa attataaata
     6361 tgagatgtga gctagagact tcagaaggtg atggtactat agcacctgca ttttcaaatg
     6421 aatggaataa gcttactgga aataaagttt gttttattca caatgcaaaa gatggttcaa
     6481 gaataaaaaa ctggaatcat gataataact ggtttctaaa tgacactata gaaaaattta
     6541 atacaggctg tactacctta agtaaacatt ataatataga aaataaatac gttatttgga
     6601 ttcaaggtga aagtgatgca aaatatggta gtgatgtatt gtactataaa gaaagtctaa
     6661 aaaaaattgc gtataggctt aaagaagaat gtatgattga taaaatgttt gtaagtttaa
     6721 ctggttattg gcttggagaa gatgaatatt ttattagaac aagacgaatt gcagcagcac
     6781 aggagtcggc ttgtagtgaa tgtgatatat tatgtgtagg aagcaaaatt gctatgcagt
     6841 ttcatgacag aggattaact attgatgatg ttcattacac tcaagaaggt cttaatatgt
     6901 taggagagga cttatgtaaa aatatttata agtatcatat aaccaaagaa aaaagtgtat
     6961 taagtgatac tatagactta tcagaagcaa ggaaatatat ctgtgaattg gaaaagataa
     7021 gtaaaagatt tgtgtaatat aaaattttaa atagagttgt taatttataa aaataatttg
     7081 tatggagata tgttatgaaa aattacgttt gtatagatgt tggaggtact tcaataaaat
     7141 atggttttat tagagaagat ggatttataa ttgataaatc aagtcttgat actgaagcaa
     7201 aggaaaaagg tggagaagga atattagcca aaataaaaga tatagtaaaa aaatatatag
     7261 aggaaaatga aataagtggt atatgtatat caactgcagg tatggttgac ccagttgaag
     7321 gtaaaatact atttgcatta gaagaattaa ttccaaacta taaggacatg caattaaaaa
     7381 aagaagtaga aaaagagttt aatataaaat gtgaagttga aaatgatgtt aattgtgctg
     7441 gacttggtga aatgtggctt ggagcaggta gaggtgcaac atcttctata tgtttaacaa
     7501 taggtactgg aattggtgga tgtattataa taaataataa actgataaat gggtttagta
     7561 atagtgctgg tgaagtagga tatatgaatg taaatggaag ttcttttcaa gaattggcat
     7621 ctactagcag tctaattaaa aaagtagcaa aaataaaaaa tttgaatgaa aatgacttaa
     7681 atggaaaaat aatttttgat ttagcaaaga ataatgatga agattgttta aaagaactcg
     7741 ataatatgat aaaatcatta gcagttggaa tcgcaaatat atgttatgta ataaatccag
     7801 aagtggtaat tttaggtggt gggattatgg cacaagaaaa gttcctaaaa ccaaaaatag
     7861 acaaagcatt aaaggaggtt cttatagaga gagtttacaa aaacactaat atagaatttg
     7921 caaagagaca aaatgatgca ggaatgcttg gagcattata taatttttta aacaaaatat
     7981 aaagaataga agggttttta atgagtattt tagaacaatt ggaatcacca acttttaaag
     8041 tcacaaaatc agataaatta ttaatagctt atataaaaga aaatatagat gatgtatttt
     8101 ataaaccaat atcacaaata gctaaagaga gcaatattgg tgaagcaact ataactaggt
     8161 ttgtaaaaaa aatgaatttt aatggattac aggattttaa agttacttta gcacaagaaa
     8221 tatcaactat caataaaaaa aatattataa ataaaaatat acaaaatgat gagccagctt
     8281 tggatacagc aaaaaaactt ttaagttcaa atgtaaccac tttagagaac acagtagaga
     8341 taatcaatag taaggatgta catgactgcg caaggcttat aataaatgca aagaaagttt
     8401 acttcatagg tattggatat tctggtataa tagcacagga ttcaaactat aaatttatga
     8461 gaataggtct taattgtgta agttttgaca gtagtcatac aatgataatg atgtcttcca
     8521 taatggaaga aggagattta ataattgcaa tttcacattc tggtgaaaca gaggagatta
     8581 taaaaactgt aaagcttgca agagccaata atgctaaaat tatatcaatt actgaaaata
     8641 aaaattctga attaaaggat atttcagatg tacacttatc ttatgtatcg ggagaaacag
     8701 tactggaaac cggttcaata tcttctaaat tagcacaatt tttcattatt gatttagtat
     8761 atacacaggt agtaaaagaa ctttctaatg aagctattga aaggaaaatt aaaactacaa
     8821 atgctataaa attgtttaaa aatgaataaa ataagaaatt tgtaatgttt tatagagctc
     8881 tcttaaaaat ttaggaatgg agagatatta catgtctaaa ttaaaagatt ataatattga
     8941 taaagtaata atttttaata atttaagtac taaaacgaag aatcaactta aagaaaaagt
     9001 taaactaaaa agattacaaa aaaaagaaat tttattttat gaaaaagata gcttagacag
     9061 tgtttatata cttttagaag gaaaggtatc tatttttaag ataagtgaaa atggagagag
     9121 aaaagtaatt ttcatattaa atagtgggga agtcataaat gatattacac ttgacgcttc
     9181 taaaaactct actgttggct gtgaagcatt tgaaaattca attgtagctt attatagtat
     9241 tgaagaattt ttagaaatta tgcaaaatga ttttcaactt acaaaggata ttatttctta
     9301 tatggaaaga agaataagac gtttatatag acagttgaaa aattctatat ctataaaagt
     9361 agataaaaaa cttgcagcaa aattatatag gttaagt
//
LOCUS       DAEPID010000114         9375 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.115, whole genome shotgun sequence.
ACCESSION   DAEPID010000114 DAEPID010000000
VERSION     DAEPID010000114.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 9375)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 9375)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..9375
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.115"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            33..989
                     /locus_tag="KR257_003455"
     CDS             33..989
                     /locus_tag="KR257_003455"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728630.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CorA family divalent cation transporter"
                     /protein_id="HBH0032115.1"
                     /translation="MYILNLNTRETIEDFRDKFYVAENSYLILSAPKNLKLLKETLDI
                     DEITFNDCLKFDEITKLDLFDNYDFLSLNTFELRDGEAVIEEVNMYLSDNFILVVVNE
                     EHFLFEFVKNIILKNSQLEKNPVINLFKINYLILREVIKNGFESLEKVEELILQIEDE
                     MMDNINKNHVSRISDVRGLTRIIVKNTRPLLYIGDRIVKENIRYLKYSNVKKYNLENF
                     QGIDFGIDKLYNFALSTRELADKLLDIYSSRVGEKTNNLITKLTLLTAISAPLTIITG
                     IYGMNFRYMPELNWIYGYPATLFFMLCIIFVGIIIFKIKKLL"
     gene            1166..1321
                     /locus_tag="KR257_003456"
     CDS             1166..1321
                     /locus_tag="KR257_003456"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428626.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0032116.1"
                     /translation="MKGILKELTAKLYSFFYFMFWGFYFSAGYFFYKNICTSFLVRPY
                     FSDFEHK"
     gene            1451..2464
                     /gene="aroF"
                     /locus_tag="KR257_003457"
     CDS             1451..2464
                     /gene="aroF"
                     /locus_tag="KR257_003457"
                     /EC_number="2.5.1.54"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003452924.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="3-deoxy-7-phosphoheptulonate synthase"
                     /protein_id="HBH0032117.1"
                     /translation="MIVVLKMGADKNEVKKLIEAIGREGVEVNPIDGTELTVLGLVGD
                     TSKIDAKRIEANKVVEKVMHVVEPFKKANRKFHPEPSIINVNGMEIGSKKIAMIAGPC
                     SVETEDQIVSIAKDVKKSGAGFLRGGAFKPRTSPYAFQGLKYDGLDLLKKAKEKTGLP
                     IVTEIMSTQDIDIFEENVDVIQVGARNMQNFDLLKELGKTNKTILLKRGLSATIEEWL
                     MSAEYIMAGGNENVVLCERGIRTFETYTRNTLDLSAILAVKKLSHLPVIVDPSHAAGK
                     SWMVDSLSKAAIAVGADGLIIEVHNDPAHALCDGKQSIKPNEYDELISELKTIASAVG
                     REI"
     gene            2486..3550
                     /locus_tag="KR257_003458"
     CDS             2486..3550
                     /locus_tag="KR257_003458"
                     /EC_number="4.2.3.4"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423904.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="3-dehydroquinate synthase"
                     /protein_id="HBH0032118.1"
                     /translation="MEEKLLVNLKENSYNIFIKKNILKNIGEEIKKIYFGNKIFIVTD
                     ENIAKLYLDKVKNNLSESGFEIKSLILKSGEETKSFNTLPKIYDSLLDFKLTRKDLII
                     TLGGGVIGDLGGFAAATFLRGISFIQIPTSLLAQVDSSVGGKVGVDLERGKNLVGSFY
                     QPKAVFIDPNVLLSLPEKFYRDGMAEVIKYGCIKDKTFFNKLLSLKNREEVMQHIEYI
                     IHKCCFIKKTVVEADEKDFGDRMLLNFGHTLGHAIEKYYNFTGYTHGEAVAIGMYKIT
                     LESEKIGITKKGTSELIKSILMNYNLPYEIELRDNKSIVDAISLDKKNLGDTLKIILL
                     KDIGESIIYNTTSKFFQEVR"
     gene            3550..4863
                     /gene="aroA"
                     /locus_tag="KR257_003459"
     CDS             3550..4863
                     /gene="aroA"
                     /locus_tag="KR257_003459"
                     /EC_number="2.5.1.19"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902796.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="3-phosphoshikimate 1-carboxyvinyltransferase"
                     /protein_id="HBH0032119.1"
                     /translation="MGSLKIYPSKLSGDVKIPPSKSMAHRAVICSSLSNGKSRISNID
                     FSDDIIATIRAMTSLGAIIEKKEDILEISGIFSKEGILNRENQLNQPKLTIDCNESGS
                     TLRFLVPISLAFDGVKRFIGRGNLGKRPLDTYYEIFDRQNIKYSYKENQLDLIISGKL
                     KPDEFRVKGNISSQFITGLLFILPTLESDSKIIITTELESKGYLDLTLSTIKDFGVEI
                     INNNYKEFIIKGNQTYKARDYKVEGDYSQGAFYLSADAIGEDISILDLKEDSLQGDSE
                     VVEILSRMGMEILREGNKIKGITNGLNGTLIDASQCPDIIPVLSVVASLSIGRTTIIN
                     AGRLRIKECDRLHAINVELNKLGANIEEKEDSLIIEGVSKLNGGVEVWSHKDHRIAMT
                     LAIASCRCDKPIILKDFECVSKSYPHFFKDFKMLGGRIDEWNMGK"
     gene            4841..5920
                     /gene="aroC"
                     /locus_tag="KR257_003460"
     CDS             4841..5920
                     /gene="aroC"
                     /locus_tag="KR257_003460"
                     /EC_number="4.2.3.5"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902798.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="chorismate synthase"
                     /protein_id="HBH0032120.1"
                     /translation="MSGIWGNNLKVSIFGESHGNAIGINIDGLPSGIELDLDNIDKEM
                     KRRAPGKNSISTSRNESDIPEILSGYFNGRTTGTPLCAIIRNSDTRSKDYGELKNLMR
                     PGHADFTGNVRYSGFNDYRGGGHFSGRITAPLVFCGAICKQILSQKGIEIGAHIKKIK
                     NIEDMSFDYVNISKQQLSNLQTLELPLLDLSKEEAMKNTIIDAKNQGDSVGGIIECAV
                     VGINVGLGNPFFDSVESTLSHLLFSVPAVKGVEFGLGFELADMYGSQSNDEMYYEGNQ
                     VKSKTNNNGGIIGGITTGMPIIFKVAIKPTPSISRQQNTVNIKDKKDDILYIKGRHDP
                     CIVQRAIPVIEAVTAIGIFDLMKGR"
     gene            5923..7119
                     /gene="pheA"
                     /locus_tag="KR257_003461"
     CDS             5923..7119
                     /gene="pheA"
                     /locus_tag="KR257_003461"
                     /EC_number="4.2.1.51"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428637.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="prephenate dehydratase"
                     /protein_id="HBH0032121.1"
                     /translation="MEDLTRYRNEIDNIDKELIQLFEKRMNTVLEIARHKMKNNTTIL
                     QKDREEKVLSRAVDNLDNKAYSQETVQFFNSIMEISRGLQKRFIDNDGEQKIEFSLDS
                     SNKNFDLSNVNKYKSLKDELNKKNILVGFPGKSGSFTEEALNKFFNKKISKKQFKEFE
                     DVFIALKNKEINYGIIPIENSSTGAISETYDLLRKYGFYIVGEECIKIDQNLIGIKDT
                     KLEDIKEIYSHTQGIGQCSEFLKQNSTWKLIPFNNTATSAELVRKLQDKTKAAIASKK
                     AASIYGLEIISPCINDIANNYTRFVVISNQIHIEEESNKMSVVFSVEHEAGKLYKVLG
                     YFAKNNINMTKIESRPMKNASWRYFFYIDFECSIYNAKVYDLLELIEHNTAYFKFMGV
                     YKNKTE"
     gene            7166..7975
                     /gene="aroE"
                     /locus_tag="KR257_003462"
     CDS             7166..7975
                     /gene="aroE"
                     /locus_tag="KR257_003462"
                     /EC_number="1.1.1.25"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902802.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="shikimate dehydrogenase"
                     /protein_id="HBH0032122.1"
                     /translation="MNFFGLVGEKLSHSVSPQIHKRVFEILNIESAYKNFEISKEDIS
                     KLDGAIKLLGIQGVNVTVPYKERIMKYLDFISPEAKRIGAVNTILLRENMLYGYNTDY
                     FGLDSMFKMANIDVQGKVAVILGTGGASKAALTYFIDSGIEKLYVSTRKKDDKKLLNS
                     KAILIDYEELKHIKGDIILNATPVGMYPNVGISPVSKSIIQNFDILIDLIYNPGETEF
                     LRIGNSMGKKTCDGLYMLVGQAIKSQEIWQDTKIDNSILDVIYNELKLEFL"
     gene            7987..8520
                     /locus_tag="KR257_003463"
     CDS             7987..8520
                     /locus_tag="KR257_003463"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003439413.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="shikimate kinase"
                     /protein_id="HBH0032123.1"
                     /translation="MINKTKEKLILIGMPGSGKTTIGKLLAKEYNCSFCDMDDYIIQI
                     SQKSIAELFSEGEDIFRNYETQACRELSISDKTVISTGGGVIKKDINMEILKETGIII
                     FIDRPIQKILEDININSRPLLKNGKDRLYNLYNERINLYKKFSDIEILNDKSLNNAVY
                     NITNAVSENFKFDFKEK"
     gene            8541..>9375
                     /locus_tag="KR257_003464"
     CDS             8541..>9375
                     /locus_tag="KR257_003464"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897031.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="prephenate dehydrogenase"
                     /protein_id="HBH0032124.1"
                     /translation="MNIVIVGLGVIGGSFAKALKKAGYENVFGVDVDLETLKKAEKAK
                     IIKKGCTTGKELFKKADLIILSIYPRLVVDFLNNNKNFFKKGTIITDTTGIKETLIND
                     VLQIIPDDIDFIFGHPMAGREKKGIDFASEQVFNGANYIITPTGRNNIKNLELVENLI
                     LEIGFKRVKKLTSQKHDEIIAFTSQLPHVMAVALINSDEEGRDTGKFIGDSYRDLTRI
                     ANMNEDLWSELFLGNRDNLLKVIENFESEVNLVKEAIFNNDKNKLIEYFKKSSIRREA
                     LE"
BASE COUNT         3848 a          921 c         1661 g         2945 t
ORIGIN      
        1 tagaatgtaa attgaaattt aggagtagat gtatgtatat actgaattta aatacaagag
       61 agactattga agattttaga gataaatttt atgtagcaga aaattcttat cttatattaa
      121 gtgctccaaa aaatttaaaa ttgcttaagg aaactttgga tatagatgaa ataactttta
      181 atgattgtct taaatttgat gaaataacca aacttgattt atttgataat tacgattttt
      241 taagcctaaa tacatttgaa ctaagagatg gagaagctgt tatagaagag gtaaatatgt
      301 atttatcaga taattttata ttggttgtag tgaatgaaga acacttttta tttgaatttg
      361 taaaaaatat tattttgaag aactctcaac ttgaaaaaaa tccagttatt aatctattta
      421 agataaacta cttgattctt agagaagtta taaaaaatgg ttttgagtct ttggaaaaag
      481 ttgaagagtt aattcttcaa atagaagatg aaatgatgga caacattaat aagaatcatg
      541 tatctagaat aagtgatgta agaggattaa caagaattat agttaagaat actagacctc
      601 ttttgtatat tggggataga atagttaagg aaaatataag atatttaaaa tattcaaatg
      661 taaaaaaata taatttagaa aattttcaag gtatagattt tggaattgac aaattataca
      721 atttcgcatt gtcaacacga gagttagcag ataaattatt agatatttat tcttccagag
      781 taggtgagaa aacaaataac ttaattacaa aattaacctt gttaacagcc atatcagcac
      841 cacttacaat tataactggt atatatggaa tgaactttag atatatgcca gaattaaact
      901 ggatttatgg atatccagca actttatttt ttatgctatg tataattttt gttggaatta
      961 taatatttaa aataaaaaaa ttattgtaaa ttacagatga tgtttaattg attttataaa
     1021 aatacatcaa ttgagaagct gatttaagta aataaaaaaa tattttaaat tgaaaatatt
     1081 tatagaaaat attgacaatt atattttctt tgttataatt attaaacaag aagaataata
     1141 aattataaaa atggaggata atactatgaa aggaatatta aaagaactaa cagcaaaact
     1201 ttatagcttt ttttacttta tgttctgggg cttttatttt agcgctggct atttctttta
     1261 caaaaatata tgtacttcct ttctggtgag gccttatttt agtgattttg agcataagta
     1321 aattttataa aaatgattat tttatatatt tatataagat ttagtgcttg atagattatt
     1381 ttagagaact cattagtgag ttctcttttt tattttaaat ataaaattat aatattggga
     1441 ggtagtaaaa atgatagtag tattaaaaat gggagcagat aaaaatgaag ttaaaaaatt
     1501 aattgaggct attgggagag aaggagtaga agttaatccc atagatggaa cagaattaac
     1561 tgttttaggt ttagttggag atactagtaa aatagatgcc aaaagaatag aagcaaataa
     1621 ggtagttgaa aaagttatgc atgtggtaga gccttttaaa aaggccaata gaaaatttca
     1681 tccagaacct tcaatcataa atgttaatgg aatggaaatt ggttcaaaga aaattgctat
     1741 gatagctggg ccttgttctg ttgaaacaga agaccaaata gtatctatag ctaaagatgt
     1801 gaaaaaatca ggtgcaggat ttttgagagg tggagcattc aaaccaagaa catcaccata
     1861 cgctttccaa ggattgaaat atgatggatt ggatttatta aaaaaagcaa aagaaaaaac
     1921 agggcttcct atagttacag aaataatgtc aacacaagat atagatatat ttgaagaaaa
     1981 tgtagatgta attcaagttg gagctagaaa catgcaaaac tttgatttat taaaagaatt
     2041 aggtaaaaca aataaaacaa tacttttaaa aagaggatta tctgctacaa ttgaagagtg
     2101 gctaatgtca gcagagtata taatggctgg aggaaatgaa aatgtagttc tttgtgaaag
     2161 aggtataaga acttttgaaa catatactag aaatactttg gatttaagtg caattttagc
     2221 tgtgaagaaa cttagtcatt taccagttat agttgaccca agtcatgcag caggtaaatc
     2281 atggatggtt gactctttat ctaaggcagc aattgcagtt ggagcagatg gtctaataat
     2341 cgaagttcat aatgacccag cacatgcact ttgtgatgga aaacaatcga ttaagccaaa
     2401 tgaatatgat gaattgataa gtgaattaaa gactatcgca tcagcagttg gtagagaaat
     2461 ataatctata aaaggatggt taaacgtgga agaaaaacta ttagtaaatt taaaagaaaa
     2521 tagctacaat atatttatta aaaaaaatat actaaagaat ataggagaag aaataaaaaa
     2581 aatatatttt ggaaataaga tttttattgt aactgatgaa aatatagcaa aattatactt
     2641 ggataaagta aaaaataatt taagtgaatc tggatttgaa attaaatctt taatattaaa
     2701 atctggtgaa gaaacaaaat catttaatac tcttcctaaa atatacgata gtttacttga
     2761 ctttaagtta actagaaaag atttgattat tactttagga ggaggggtaa taggtgattt
     2821 aggtggattt gcagcagcaa cttttttaag aggtataagt tttattcaaa ttccaacatc
     2881 tttattagca caagttgata gttctgtagg tggaaaagtt ggagttgacc ttgagagagg
     2941 caaaaactta gtgggaagct tttaccaacc aaaggctgtg tttatcgacc caaatgtatt
     3001 attatcactt ccagaaaaat tctatagaga tggaatggca gaagttataa aatatggatg
     3061 tataaaagac aaaacttttt tcaataaact tttaagttta aaaaatagag aagaagtaat
     3121 gcaacatata gaatacatta tacataaatg ttgctttatt aaaaaaactg tagttgaagc
     3181 tgatgaaaaa gactttggag atagaatgct tctaaacttt ggccatacat taggtcatgc
     3241 tattgagaaa tactacaatt ttacgggtta tacccatgga gaagctgttg ccataggaat
     3301 gtataagata actttagaaa gtgaaaagat aggaattaca aaaaaaggga catcagaact
     3361 tataaaatca attttaatga attataattt gccttatgag attgaattaa gagataataa
     3421 atctatagta gatgctatat ctcttgataa aaaaaatcta ggtgatacat taaaaataat
     3481 acttttaaaa gatattggag agagtattat atataatact acttctaaat tttttcagga
     3541 ggtaagataa tgggaagtct aaaaatatat ccaagtaaat tatctggaga tgtaaaaata
     3601 ccaccatcaa aaagtatggc acatagggca gttatttgtt catctctaag caatggaaaa
     3661 agtagaattt ctaatataga tttttctgat gatataatag ctactataag agcaatgaca
     3721 tcattaggag ctattataga aaagaaagaa gatattttag aaatttcggg aattttttct
     3781 aaagaaggta ttttaaatag agagaatcag ttgaatcaac ctaaattgac aatagattgt
     3841 aatgaatcag gctctacatt gagattttta gtacctatat ctttagcatt tgatggtgta
     3901 aaaaggttta taggtagagg aaatcttgga aaaagaccac ttgatactta ttatgagata
     3961 tttgacagac agaatataaa atatagttac aaagaaaatc agttagattt gattatatca
     4021 ggtaagctta aaccagatga atttagagta aaaggaaata taagttctca gtttatcaca
     4081 ggtttactgt ttatattgcc tacgctagag agtgattcaa agataataat tactactgag
     4141 ctagaatcta aaggatattt agatttaact ctttcaacga taaaagattt tggggtagaa
     4201 attataaaca ataactataa agaatttatt ataaaaggaa atcaaacgta taaagcgaga
     4261 gattataaag tagaaggaga ttattctcaa ggagcatttt atttatcagc agatgctata
     4321 ggagaagata ttagcatatt agaccttaaa gaagattctc ttcaagggga tagtgaagta
     4381 gttgaaattt tatctaggat gggaatggaa atattaagag aaggcaacaa aataaaagga
     4441 ataacaaatg gtttaaatgg tactttgata gatgcatctc aatgcccaga tataatacct
     4501 gtattatctg tagtagcatc cttaagtata gggaggacta caataattaa tgctggtagg
     4561 cttagaatta aagaatgtga tagacttcat gcaataaatg ttgagttaaa taaacttgga
     4621 gcaaatatag aggagaaaga ggatagtttg ataatcgaag gagtaagcaa gttaaatggt
     4681 ggagtagagg tgtggagtca caaagaccat agaattgcta tgacacttgc aattgcttct
     4741 tgtagatgtg ataaaccaat aatattaaaa gattttgagt gtgtatcaaa atcttatcca
     4801 cattttttta aagattttaa gatgttagga ggtcgaattg atgagtggaa tatggggaaa
     4861 taatttaaaa gtatcaattt ttggagaatc tcatggaaat gctataggta taaatataga
     4921 tggtcttcct tcggggattg aacttgacct tgataatatt gataaagaaa tgaagagaag
     4981 agcacctgga aaaaattcta tatctacttc aagaaatgaa agtgatatac cagaaattct
     5041 aagtggatat tttaatggaa gaactacagg aacgccatta tgtgcaatca taagaaatag
     5101 tgatactcgt tcaaaagatt atggagagct taaaaactta atgagaccag gacatgcaga
     5161 tttcacaggt aatgtgagat attctggatt taatgactat agaggtggag gtcatttttc
     5221 aggtaggata acagctccat tagtattttg tggggctata tgtaaacaaa ttttatcaca
     5281 aaaaggaata gagataggag cacacataaa aaaaattaaa aatatagaag atatgagttt
     5341 tgattatgta aatatttcaa aacaacagtt atcaaatttg caaactttgg aactaccttt
     5401 acttgattta tcaaaggaag aagccatgaa aaatacgatt atagatgcaa aaaatcaagg
     5461 agattcagtt ggtggtataa ttgagtgtgc agtagtaggt attaatgtag ggcttggaaa
     5521 tccatttttt gactctgttg aatctacttt atcacattta ttgttttctg ttcctgctgt
     5581 aaaaggtgta gagtttggtt taggttttga acttgcagat atgtatggct ctcaaagtaa
     5641 tgatgaaatg tattatgaag gaaatcaagt taagagcaaa acaaataaca atggaggaat
     5701 tataggaggg attactactg gaatgccaat aattttcaaa gtggcaatta agccaactcc
     5761 atcaattagc agacaacaaa acacagttaa tataaaagat aaaaaggacg atattttata
     5821 tattaaaggc agacatgacc cttgtatagt tcaaagggct atacctgtaa tagaagcagt
     5881 aacagccatt ggaatttttg atttgatgaa aggacgataa taatggagga tttaacgaga
     5941 tatagaaatg agattgacaa tatagataaa gagcttattc aattatttga aaagagaatg
     6001 aatacagttc ttgaaattgc cagacataaa atgaaaaata acactactat acttcaaaaa
     6061 gatagagaag aaaaagtact aagtagagcc gtagataatt tagataataa agcatattca
     6121 caagaaacgg tacagttttt taattctata atggaaatta gtagaggatt acaaaaaaga
     6181 tttatagata atgatggtga gcagaaaatc gagtttagtt tagattcatc aaataagaat
     6241 tttgatttgt caaatgtaaa taaatataag tctttaaaag atgaattaaa taaaaaaaat
     6301 atcctagtag gctttcctgg aaaatcaggt tcatttacag aagaagcact aaataaattc
     6361 ttcaacaaaa aaatatcaaa aaaacaattt aaagaatttg aagatgtttt catagcactt
     6421 aaaaataaag aaataaacta tggaataatc cccatagaaa attcatctac aggagctatc
     6481 tctgaaactt atgacctttt gagaaagtac ggtttttata tagttggaga agaatgtata
     6541 aaaatagacc aaaatttaat agggataaaa gacacaaagc ttgaagatat aaaagaaata
     6601 tattctcata cacaaggtat aggacaatgt agtgaatttt taaaacaaaa tagtacatgg
     6661 aaattgatac cctttaataa cacagcaaca agtgcagaac ttgtaagaaa acttcaagat
     6721 aaaacaaaag cagcaattgc aagcaaaaaa gctgcaagta tttatggatt agaaataata
     6781 agtccttgta taaatgatat agcaaacaac tatacaagat ttgtagtaat cagtaatcaa
     6841 atacacattg aagaagaatc aaacaaaatg agtgtagtat tttctgttga acatgaagca
     6901 ggaaaacttt ataaagtact tggatacttt gctaaaaata atataaatat gacaaaaata
     6961 gaatcaagac ctatgaaaaa tgcctcatgg agatatttct tttatataga ttttgagtgt
     7021 tctatataca atgctaaagt gtacgattta ttagaattga tagaacataa tacagcatat
     7081 tttaaattta tgggagtata taaaaataaa actgaataga taagataaat ttttatttaa
     7141 tttataatta ttaggaggtg taagtatgaa ttttttcggt ctagtaggtg aaaaactctc
     7201 tcacagtgtt tcacctcaaa tccacaagag agtattcgag atattgaata ttgaaagtgc
     7261 ttataaaaac tttgaaattt caaaagaaga tatatctaag ctagacggtg ctataaaatt
     7321 attaggaata caaggggtaa atgttactgt accatataag gagcgtatta tgaaatatct
     7381 tgattttata tcaccagagg caaaacgtat aggagcagtt aatacaattt tactcagaga
     7441 aaatatgtta tatggttaca atacagatta ctttggtctt gatagtatgt ttaaaatggc
     7501 taatattgat gttcaaggaa aagtagcagt tatattagga actggaggtg cttctaaagc
     7561 tgctcttaca tattttattg attctggtat agaaaagctt tatgtttcaa ctagaaaaaa
     7621 ggatgataaa aaattattaa atagtaaagc tatattaata gattatgaag aacttaaaca
     7681 tataaaagga gatataatat taaatgctac accagtaggt atgtacccta atgtaggaat
     7741 ttcaccagtg tcaaaatcta ttatacaaaa ttttgatata ttaatagatt taatttacaa
     7801 tcctggagaa acagagtttt taagaattgg taatagtatg ggtaaaaaaa cttgtgatgg
     7861 attatatatg ctggtggggc aagcaataaa atctcaggaa atttggcaag atactaaaat
     7921 agataatagt attttagatg ttatatataa tgaactaaaa ttagaatttt tgtaagggag
     7981 attgttatga taaataaaac aaaagaaaaa ttgatattaa taggtatgcc aggtagtgga
     8041 aaaactacaa ttggtaaact tttggccaaa gaatataatt gtagtttctg tgatatggat
     8101 gattatataa ttcaaatatc tcaaaaaagt atagcagagt tgttttcaga aggagaagat
     8161 atctttagga actatgagac tcaagcatgt agagaacttt ctataagtga taaaacagtg
     8221 atatctacag gtggaggtgt aataaaaaag gatattaata tggaaatact aaaagaaaca
     8281 ggtataataa tttttattga tagacctata caaaagattt tggaagatat aaatattaat
     8341 tcaagaccat tattaaaaaa cggaaaagat agattgtata atctttacaa tgagagaata
     8401 aatctttata aaaaattttc agatatagag attttaaatg ataaatcatt aaataatgct
     8461 gtatataata ttacaaatgc agtcagtgaa aattttaaat ttgactttaa agaaaaataa
     8521 tctaggggga aataaaaata atgaatattg ttattgtagg actaggagtt ataggaggct
     8581 cttttgctaa agcattaaaa aaagctggat atgaaaatgt atttggagta gatgtagatt
     8641 tagaaacttt aaaaaaagca gaaaaagcaa aaatcataaa aaaaggatgt actacaggta
     8701 aagagttatt taaaaaagct gatttaatta tattatctat atatcctaga ttagttgtag
     8761 attttctaaa taataataaa aactttttta aaaaagggac tataattact gatactacag
     8821 gaataaaaga aacacttatc aatgatgtgt tgcaaattat tccagatgat atagatttta
     8881 tatttggaca tccaatggca ggtagggaaa aaaagggtat tgattttgca agtgaacaag
     8941 tttttaatgg cgcaaattat ataattactc caactggcag aaacaacata aaaaatttag
     9001 agttagttga aaatttaatt ttagagattg gatttaaaag agtaaaaaag ttaacttcac
     9061 aaaaacatga tgagattata gcttttactt ctcagttacc tcatgttatg gcagttgctc
     9121 ttataaatag tgatgaagaa ggtagagata cgggtaaatt tattggagat agttatagag
     9181 atttaactag aattgcaaat atgaatgaag acttatggag tgaacttttt ttaggaaata
     9241 gagataattt actaaaagtt atagaaaact ttgaatcaga agtaaattta gtaaaagaag
     9301 ctatatttaa caatgataaa aataaattaa tagagtattt taaaaaatca tcaataagaa
     9361 gagaagcttt agaaa
//
LOCUS       DAEPID010000115         9341 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.116, whole genome shotgun sequence.
ACCESSION   DAEPID010000115 DAEPID010000000
VERSION     DAEPID010000115.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 9341)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 9341)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..9341
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.116"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            312..1688
                     /locus_tag="KR257_003465"
     CDS             312..1688
                     /locus_tag="KR257_003465"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418253.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Trk family potassium uptake protein"
                     /protein_id="HBH0032125.1"
                     /translation="MKTIVRRLILYADGMRPTQIMVSGFAAIIVIGALLLTLPIASQS
                     GESIGLLNALFTATSAVCVTGLVMVDTATYWSLFGQIVIITLIQIGGLGFMTVATMFS
                     LMARKKIQLRERLLIQESLNQADLSGLVRLTRFVLIITITIEGIGALVLSTVFIPQFG
                     LSKGIWYSVFHAISAFCNAGFDLMGSVSGPFTSLNSYVNNFTVSMTVCALIVLGGLGF
                     PVVLDIVRKRRFSKLNVHSKVVLFSTATLIFVGALFIFLIEFNQKATMADLPLKGKVL
                     SAIFQSVTARTAGFNTLDLATLRESSVFVMIILMFIGASPASTGGGIKTTTLAVLIIT
                     VRSFLSGKSDIEAFERRLAPSTIKKSLGIFVISISAVIFGTLIISITQPNFTLVQSAF
                     EVTSALATVGSSLAGTPNLNALGKIIIIIFMFMGRVGSLTLFMAILSGGRRKSQPIRY
                     AEGKIMVG"
     gene            1975..2646
                     /locus_tag="KR257_003466"
     CDS             1975..2646
                     /locus_tag="KR257_003466"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418257.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TrkA family potassium uptake protein"
                     /protein_id="HBH0032126.1"
                     /translation="MKQYIVIGCGRFGSSVASTMHLLGHQVMAIDKNEDSVQSISDKV
                     THSLIVDVTDEQALRSLGLGNFDVAVVAIGSDIRASIMATLIAKEMGVELIICKAKDE
                     LQAKVLYKIGADRVVFPERDMGVRVAHNLVSDNILDHIELDPEYSIVEIVTPNSWVGK
                     TLIELELRARYEITVLAIKTGKNINVTPSPDEELTAGSILVIIGQNTSITAITSGNKG
                     IIRRR"
     gene            2835..3632
                     /locus_tag="KR257_003467"
     CDS             2835..3632
                     /locus_tag="KR257_003467"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436797.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RNA methyltransferase"
                     /protein_id="HBH0032127.1"
                     /translation="MITNINSKDNEKLKYTRALLKSKNRNKESKFIIEGYRIVMLALE
                     CMANLDYVFINEEFENKKEHVKLLEDLDKKNTKIYKTTNKNFKELVDTENTQGIIGVV
                     SFKKKKLSESINKKDKFVLILDRIQDPGNMGTIIRTADSAGVDAIIALKGCVDIYNPK
                     VIRSTMGSIFDVNIIDASQDETVDMLKSLDFNIVSSYLNTENFYDKIDYGSKVALVIG
                     NEANGINEELVSKSDILVKIPIYGKAESLNAAISSAILMYEIKKYLI"
     misc_binding    4018..4252
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00230"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="T-box leader; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /bound_moiety="tRNA"
                     /db_xref="RFAM:RF00230"
     gene            4302..5321
                     /gene="pheS"
                     /locus_tag="KR257_003468"
     CDS             4302..5321
                     /gene="pheS"
                     /locus_tag="KR257_003468"
                     /EC_number="6.1.1.20"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000388219.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phenylalanine--tRNA ligase subunit alpha"
                     /protein_id="HBH0032128.1"
                     /translation="MQEKLLALREAALAEIKEAQSIESVESLRVKYLGKKGEITAILK
                     EMGKLSAEERPVVGKVANEVRENIELSINSKKEEINAIEKERKLKEEVIDVTQPGKVL
                     KVGKKHPITQIIDEVTDIFIGMGFSIAEGPEVETVENNFDALNAPKDHPSRDMSDTFY
                     INDGVLLRTQTSPVQVRTMRSQELPIKVIAPGRCFRSDSPDATHSPMFHQIEGLVVGK
                     DVTMAEFKGTMDIFVEKLFGSDIKTKFRPHNFPFTEPSAEVDVTCFKCGGKGCPMCKY
                     EGWIEILGSGMVHPNVLRNCGIDPEVYSGFAFGVGVERLAMLKYEIDDIRLLFENDMR
                     FLNQF"
     gene            5338..7731
                     /locus_tag="KR257_003469"
     CDS             5338..7731
                     /locus_tag="KR257_003469"
                     /EC_number="6.1.1.20"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888509.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phenylalanine--tRNA ligase subunit beta"
                     /protein_id="HBH0032129.1"
                     /translation="MLVSLKWLRDYVDIDMDVKEFADKMTMTGTKVETIDYYGEEIEN
                     ILVGKILEIKQHPNADKLVVTKVDIGDKVVQIVTGATNISEGDYIPVAVNGSKLPGGV
                     EIKQTDFRGELSDGMMCSAAELGIDEHYIEEYKRGGIYILDHEDSYELGKDIKDVLGL
                     KDALIDFELTSNRPDCKCMMGIAREAAATIGTKVKYPEIEVKESDEEIDFKVEIDNPD
                     LCRRYVARMVTDVKIEPSPYWMQRRLTEAGVRPISNIVDITNFVMLELGQPLHAFDIN
                     QVETGRIVVRNAKDGEKLVTLDDVERTLDKDMLVITNGEKSLGLAGVMGGANSEITSN
                     TKTVLFESANFKPENIRMTAKKVGIRSEASSRNEKDLDPNLAEIAANRAAQLVEMLGA
                     GKVLKGVVDVYPNKPEPKKLVVNPQRINHLLGVDVPMEQFVGILESLEFKCNLVANDK
                     LEIDVPSFRTDMEQEADVWEEIARIYGFENIPSVQLEGNTTAGIKTSKQKFMDALKDN
                     STAVGLNEILTYSFVSPKGVDKIRVPEGNAKRNFVKLLNPLGEETSVMRTTLIPNMLD
                     VLSTNVSHKIEEVSAFECGHIFIPQDSELPKEENRMCVGMYGKDVDFFALKGTIETIL
                     VNVGFKGYEIEPQDNNTTFHPGRCAKIVYNNKYVGTLGELHPDVIENYNLGQRVYVAE
                     IDIDFVFDNSDRTKNYVPLPKYPSTSRDIALIVKDDVFVKQIEDIIKENGQGLVESYK
                     LFDVYKGSQIEAGYKSIAYSITYRSKDKTLTDEDVAKVHDKILSELSEKLNANLRSN"
     gene            7756..8346
                     /gene="zapA"
                     /locus_tag="KR257_003470"
     CDS             7756..8346
                     /gene="zapA"
                     /locus_tag="KR257_003470"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009905089.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell division protein ZapA"
                     /protein_id="HBH0032130.1"
                     /translation="MNKVMVKIHGAEYPMVGDKSEKFMISIADFVDKEMDKITRQNPK
                     LSLSVAAILTALNISDLLFECSDENEKLIKANEELSKKVGASNEELQLEIKSLKLTIA
                     EKEAENREAETKMKELIEIIENKKQEIFELSNTTEGSRAELDAYKNKIEELSTQLEEA
                     NERATIAENLASEFQNKAYDLQLKCTGLNNDAKNVE"
     gene            8522..9205
                     /locus_tag="KR257_003471"
     CDS             8522..9205
                     /locus_tag="KR257_003471"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003432289.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1275 domain-containing protein"
                     /protein_id="HBH0032131.1"
                     /translation="MTSKSQMSESFFLCSLLAITGGFLDIYTYVVRGKVFANAQTGNI
                     VLFGLNIAEGNVKESFYYLIPILAFMLGVFIAEKIRKYFTNNKTKIHWRQVIIIIEMI
                     TILIVSFIPRGRFNMFVNVAISFICSMQVESFRKVNGNSFATTMCTGNLRSATETLFH
                     YIHTKNIFMIKKSLQYYAVIIFFISGAILGTFFTKIFVEKSILICFFILAVVFGIMFI
                     NKDDSFNEN"
BASE COUNT         3622 a         1013 c         1775 g         2931 t
ORIGIN      
        1 tttaacttca aaaaagtata tgaaatttat actggtaaaa tgataaataa attttaagta
       61 caaaatagta aaagctatga tagttttaga cctattatat gtaaaaaata tagatgtttt
      121 tggtgcaatt taaattaaaa gatatatata aaaatttaaa atattccaaa cagaaattat
      181 aaaaattact atcattgtct ttatacaata tttatactat aatagaataa taatttagag
      241 gaaagctcta aaaataaaca aattaagggt cttaacagta gtgattttat gttaaggagg
      301 tataaagaaa gttgaaaaca atagttagaa gacttattct ctacgcagat ggaatgcgtc
      361 ctactcaaat aatggtatct gggtttgctg cgattattgt aatcggagca ttgttgttaa
      421 cactcccgat agcgtcgcag agtggagaga gtataggctt attaaatgct ctatttacgg
      481 ctacttcagc ggtttgtgtt actggtctag ttatggtaga tacagcaact tattggagtt
      541 tatttggaca gatagttata ataacattga tacaaattgg tggtcttgga tttatgaccg
      601 tagccacaat gttttcactt atggcacgaa aaaaaataca actaagagaa agattattaa
      661 tacaagagtc attaaatcaa gctgatttat cgggacttgt aagacttaca agatttgtat
      721 taataataac cataacaata gagggaatag gtgcactggt tttatcaact gtctttattc
      781 cacaatttgg tttgtctaaa gggatatggt atagtgtatt tcacgcaata tcagcgtttt
      841 gtaatgccgg atttgacttg atgggcagtg taagtggccc atttacatcg ttaaattctt
      901 atgtaaacaa ctttacagta tcaatgactg tttgcgcact tatagtgctt ggagggctag
      961 gattccctgt tgtacttgat attgtaagaa aaagaagatt ttcaaaatta aatgtgcatt
     1021 ctaaggttgt attgttttca actgctacac ttatttttgt gggtgcatta tttatttttc
     1081 ttatagaatt taatcaaaaa gctactatgg cggacttgcc tttaaaggga aaagtactat
     1141 cagcaatatt tcaatcagta acagcaagaa ctgctggttt taatacgctt gatttagcta
     1201 ctttacgaga aagtagtgta tttgtaatga taattttgat gtttattgga gcatcacctg
     1261 catcaactgg tgggggtata aaaacaacaa cactagctgt tttaatcatt acagttagaa
     1321 gttttctatc aggaaaatca gatatagaag cttttgaaag aagattagct ccatcaacta
     1381 taaaaaaatc tcttggtata tttgtaatca gtatatcagc agttattttt ggaacattga
     1441 ttatttcaat aactcagcct aattttacat tagttcaatc agcttttgag gttacatcag
     1501 cacttgctac agttggttca agtttagctg gaactccaaa cttaaatgct ttaggtaaga
     1561 ttataataat aatctttatg tttatgggta gagttggttc tcttacttta tttatggcta
     1621 tactttctgg tggtagaaga aagagtcaac caatcagata tgcagaaggt aaaattatgg
     1681 ttggttaagt taccaaggag taatataaat ttataatgga tttagagtag cactgtaaat
     1741 ctgttgataa aataaatgag cctagatgta attatatgaa gaaataaaat cgactaacga
     1801 acaaaattaa ttaatgaaat aaaaaaacag ggaaataaaa tacaaataaa aaggtaaatc
     1861 aaaattaaat taatctgtgt atataaaatt atatattgtg tataagtttt gtatgtgtaa
     1921 acaattaatt taagagatat tatataaatt gtgtattagg gaggaagttt cgagatgaag
     1981 caatatatag tcattgggtg tgggagattt ggaagttcag ttgcgtctac tatgcatctt
     2041 ttaggacatc aagtaatggc aatagacaaa aatgaagatt cagttcaaag tatatctgac
     2101 aaggtaaccc attcacttat agtggatgtt actgatgagc aagcgttaag gtcattaggt
     2161 ttaggtaact ttgatgtagc agtagttgca ataggttctg atataagggc atctataatg
     2221 gcgactctta tagccaaaga aatgggtgta gagttgataa tatgtaaggc aaaggatgaa
     2281 ttacaagcta aagtgcttta taaaattggc gcagatagag ttgtatttcc agaaagagat
     2341 atgggagtaa gagttgcaca caatttagtt tcagataata tattagacca tattgaactt
     2401 gacccagagt attcaattgt tgaaatcgta actccaaata gttgggttgg caagacactt
     2461 atagagcttg aattaagagc tagatatgag ataactgtac ttgctataaa aacaggtaaa
     2521 aatataaatg ttacaccttc tccagatgag gaacttacag ccggaagtat cctagttata
     2581 atcggtcaaa atactagtat aacagcgata acatctggaa ataaggggat aattagaaga
     2641 agataattta ctatttaata tatatttaat tgcaatgaaa gtagatagta tcatataatt
     2701 atgaatagtt atatgatact atttttttaa tcgaaggtag tatttatttg taagattaga
     2761 taaagagaaa ttaaattaaa agtaaggagg ctgtgctaat ataaaaattt ataagttatt
     2821 agcatttaga taaaatgatt acaaatataa acagtaagga taatgaaaag ttaaagtata
     2881 caagagcact attaaaatca aagaatagga ataaagagtc aaagttcata atagagggat
     2941 acagaatagt aatgcttgca cttgaatgta tggcaaacct tgattatgta tttatcaatg
     3001 aagaatttga aaataagaaa gaacatgtaa aactattaga agatttggat aaaaaaaaca
     3061 caaagatata caagactact aataaaaact ttaaagaatt agtggataca gaaaatactc
     3121 aaggaataat aggtgtagtt tcatttaaga aaaaaaaatt aagtgaaagt ataaataaaa
     3181 aagataaatt tgtattgatt ttagacagaa tacaagaccc aggaaatatg gggactataa
     3241 taaggactgc tgattctgct ggagtagatg ccataatagc actaaaggga tgtgtcgata
     3301 tatacaaccc aaaagtaatt aggtctacta tgggttctat ttttgatgtg aatataattg
     3361 atgcttcaca agatgaaact gtggacatgc ttaaatcatt ggattttaat atagtttcaa
     3421 gttacttaaa tacagaaaat ttttatgaca aaatagatta tggctcaaaa gtagcattgg
     3481 tgataggaaa cgaagcaaat ggaataaatg aagaacttgt atcaaagtct gatattttgg
     3541 ttaagatacc tatatatggt aaagccgagt cgttaaatgc tgcgataagc tctgctatac
     3601 tgatgtatga aataaaaaaa tacttaattt aatgtattgt aataaatata atgtcatgtt
     3661 ataatcttga attaaatagt agagtatcaa aaatagtcaa tatatattaa aaaaataatt
     3721 aaattaatta tatattagat gtatattata taaaaaataa ttgagttagt tatgcattag
     3781 atgtatatta tataaaaaat aattgagtta attatgcatt agatgtatat tatataaaaa
     3841 ataattgagt taattatgca ttagatgtat attatataaa aaataattga gttaattatg
     3901 cattagatgt atattatata aaaaataatt aaattaatta tgtattggat atatattaaa
     3961 aatagtcaca taatttgaat ggaaatgata taatactaaa ataaacaata taatattgta
     4021 aatgcaatga aagaggaaag tattttgatt aaacttagta aagagataaa cacctaggct
     4081 gggagtgttt tctaagaggt catgagaagt tccctctgga gtaacagagc tgaaatttta
     4141 cagtaggctt tgacgtcaaa aacgcgttaa gtttgttaga ggtggtttga tgatttttaa
     4201 attgttaaac tactagggtg gtaccgcgaa actatagcct ttcgtcccta gacagggatt
     4261 gaggggcttt ttttatacaa aaaaacgaaa gggtgatatg tgtgcaagaa aaattacttg
     4321 ctttacgtga agcagctttg gctgaaataa aagaagcaca aagcatagaa agtgtagaaa
     4381 gtttaagagt taagtactta ggaaaaaaag gtgagataac tgccatactt aaagaaatgg
     4441 gtaaattatc tgctgaagaa agaccagtag ttggtaaggt tgccaatgag gtaagagaaa
     4501 acattgaact tagcataaat tctaaaaaag aagaaataaa tgctattgaa aaagaaagaa
     4561 aattaaaaga ggaagtgata gatgttactc aaccaggaaa agttttaaag gttgggaaga
     4621 agcatccaat aactcaaatt atagatgaag taacagatat atttatcgga atgggattct
     4681 ctatagcaga agggccagaa gttgagactg ttgaaaacaa ctttgacgca ttaaacgctc
     4741 ctaaagacca tccatcaaga gatatgagcg atacattcta tatcaatgat ggggtattac
     4801 ttagaactca aacatctcca gttcaagtaa gaactatgag aagtcaagag ttaccaataa
     4861 aagtaattgc accaggtaga tgttttaggt cagactcgcc agatgctaca cactcaccaa
     4921 tgttccatca gatagaaggg cttgttgttg gaaaagatgt tactatggca gaatttaaag
     4981 gaactatgga tatcttcgtt gaaaaattgt ttggttctga tatcaaaact aagtttagac
     5041 ctcacaactt cccatttaca gaaccaagtg cagaggttga tgttacttgt ttcaaatgtg
     5101 gtggtaaagg ttgcccaatg tgtaaatatg aaggttggat agaaatatta ggttcaggta
     5161 tggttcatcc aaatgtgctt agaaattgtg gaatagaccc agaagtttac agtggatttg
     5221 catttggagt tggggttgaa agacttgcaa tgcttaaata cgaaatagat gatattagat
     5281 tattattcga aaatgatatg agattcttaa atcaatttta attaggaggg tatgtagatg
     5341 ttagtatctt taaaatggct tagagactat gttgatatag acatggatgt aaaagagttc
     5401 gctgataaaa tgacaatgac aggaactaaa gttgaaacaa tagattatta tggtgaagaa
     5461 atagaaaata tattggttgg aaagatttta gaaataaaac aacatccaaa tgctgataag
     5521 ttggttgtaa ccaaagtaga tattggagat aaagttgttc aaatagttac aggagctaca
     5581 aatatatcag aaggagatta tattccagta gctgtaaatg gttctaagtt acctggagga
     5641 gttgaaatca aacagactga tttcagaggt gaattatcag atggtatgat gtgttcagca
     5701 gctgaactag gtatagatga acattacatt gaggagtata aaagaggtgg tatatatatt
     5761 ttagaccacg aagattctta tgaattagga aaagatataa aagatgtttt aggattaaaa
     5821 gatgctttaa tagattttga attaacttca aacagacctg attgtaaatg catgatgggt
     5881 atagctagag aagcagctgc aactatagga acaaaagtaa aatatcctga aatcgaagta
     5941 aaagaaagtg acgaagagat agatttcaaa gttgagatag ataatccaga tttatgtaga
     6001 agatatgttg ctagaatggt tacagatgta aaaatagaac cttctccata ttggatgcaa
     6061 agaagactta cagaagcagg agtaagacct ataagtaaca tagtcgatat aacaaacttc
     6121 gtaatgttag agcttggtca accacttcat gcttttgata taaatcaagt agagactgga
     6181 agaatagtag taagaaatgc taaagatgga gagaaacttg taacattaga tgatgttgag
     6241 agaacattag acaaagatat gctagttata acaaatggag aaaaatcact tggtttagct
     6301 ggtgtaatgg gtggtgctaa ctcagaaata acttctaata cgaagactgt actttttgaa
     6361 agtgccaatt tcaaaccaga aaacataaga atgacagcta aaaaagttgg tattaggtca
     6421 gaagcatctt caagaaatga aaaagactta gaccctaatc ttgcagagat agcagcaaat
     6481 agagctgcac agcttgttga aatgttagga gcaggaaaag ttttaaaagg tgttgtagat
     6541 gtatatccaa ataaaccaga acctaaaaaa ttggtagtaa atcctcaaag aattaaccat
     6601 ctattaggtg tagatgtacc aatggagcag tttgtaggaa ttttagaatc attagagttt
     6661 aaatgtaatt tggtagctaa tgataaatta gaaatagatg taccaagctt tagaacagat
     6721 atggaacaag aagctgatgt atgggaagaa atagctagaa tttatggatt tgagaatata
     6781 ccttctgtac aattagaagg aaatacgaca gcaggaatta aaacttcaaa acaaaaattc
     6841 atggatgctt taaaagataa ttcaactgct gtaggattaa atgaaatatt aacatattca
     6901 tttgtaagcc ctaagggagt agataagata agagtaccag aaggtaatgc aaagagaaat
     6961 tttgttaaat tacttaaccc attaggagaa gaaacttctg taatgagaac tactttaata
     7021 ccaaatatgt tagatgtttt atcaactaat gtatctcata aaatagaaga agtatctgca
     7081 tttgagtgtg gacatatatt catcccacaa gattcagaat tacctaagga agaaaataga
     7141 atgtgtgtag gtatgtatgg taaagatgtt gacttctttg cactaaaagg aactatagaa
     7201 actatacttg taaatgtcgg atttaaaggt tatgaaattg aacctcaaga taataatact
     7261 accttccacc ctggtagatg tgctaaaata gtgtataata ataaatatgt aggtacatta
     7321 ggtgaattgc atccagatgt tatagaaaac tacaatctag gtcaaagagt ttatgtcgct
     7381 gaaatagata ttgactttgt atttgataat tctgatagaa caaagaatta tgtgccatta
     7441 ccaaaatatc catctacatc aagagatata gctcttattg ttaaagatga tgtatttgta
     7501 aaacaaatag aagatataat aaaggaaaat ggtcaaggat tagtagaaag ctacaagtta
     7561 tttgatgttt acaaaggttc tcaaatagaa gctggataca agtcaattgc atattcaata
     7621 acttatagaa gtaaagataa aactctaaca gatgaagatg tagctaaggt gcatgataag
     7681 atattaagtg aattaagcga aaaattaaat gctaacttaa gatcaaatta acaactaatg
     7741 tcgggggagg ttaggatgaa caaagtaatg gttaaaatcc atggcgctga atatccaatg
     7801 gttggagaca aatcagagaa gtttatgatt agtattgctg attttgtaga caaagaaatg
     7861 gataaaataa cacgtcaaaa cccgaaattg agcttatcag ttgctgcgat attaactgca
     7921 ttaaatatat cagacctttt atttgaatgt tcagatgaga atgagaagtt gattaaagct
     7981 aatgaagaat tgagtaagaa ggttggagca tctaatgaag agcttcaatt agaaatcaag
     8041 tctttaaagc ttacgatagc agaaaaagaa gcagaaaatc gtgaagctga aactaagatg
     8101 aaagagttaa ttgagattat agaaaataaa aagcaagaaa tattcgaact tagtaatacg
     8161 acagaaggtt ctagagcaga gttagatgct tataaaaaca agattgagga gttaagtact
     8221 caacttgaag aagcaaatga aagagctact atagctgaaa acttagcttc tgagtttcaa
     8281 aacaaagctt atgatttaca gttaaaatgt acagggttaa ataatgatgc aaaaaatgtg
     8341 gaataaacta aaagatttgc tgtctcttgt tttttgagac agcttctttt aatgtataaa
     8401 tataaatgat gtataaatat agacaatatt taaatataaa taattttttt atatcaatga
     8461 aaaatagaat ctaaaatgat tttgattttg tatctatcat tagaaagcga gaggtttata
     8521 tatgacaagc aagagtcaga tgtctgaatc attcttttta tgttctttgt tggcaataac
     8581 aggaggattt ttggatattt atacttatgt ggtaagaggt aaagtctttg ctaatgcaca
     8641 aactggaaat atagttttgt ttgggcttaa tatagcagaa ggtaatgtaa aggaatcatt
     8701 ttattatttg attcctattt tggcatttat gttaggtgta tttatagccg agaagataag
     8761 aaagtatttt acaaataata agacaaagat tcattggcgt caggttatca ttataattga
     8821 aatgattaca atacttattg tttcatttat tcctagagga agatttaata tgtttgtaaa
     8881 tgttgctatt tcttttattt gttcaatgca agtagagagt tttagaaaag taaatgggaa
     8941 tagttttgca acgacaatgt gtactggaaa tttaagaagt gctacagaaa ctttatttca
     9001 ttatatacat actaagaata tttttatgat aaaaaagagt ttacagtatt atgctgttat
     9061 tatattcttt atatctggag ctattttagg aacttttttt acaaaaattt tcgtggaaaa
     9121 atcaatacta atatgttttt ttattttggc agtggtcttt ggaattatgt ttatcaataa
     9181 agatgattca tttaatgaaa attaactttc tgtaaattta caaaaaaatg aagctgttat
     9241 ttgatatact ttatatatag caaatattgc atagattaat taaagaattt aaaatatagt
     9301 aagcaatgta taagttaata gaagtatttt aagtatagta a
//
LOCUS       DAEPID010000116         9324 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.117, whole genome shotgun sequence.
ACCESSION   DAEPID010000116 DAEPID010000000
VERSION     DAEPID010000116.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 9324)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 9324)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..9324
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.117"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            complement(108..761)
                     /locus_tag="KR257_003472"
     CDS             complement(108..761)
                     /locus_tag="KR257_003472"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888720.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GntR family transcriptional regulator"
                     /protein_id="HBH0032132.1"
                     /translation="MKVDPLTTQVYDYISKKIQNGEYEANQRITESEICKSIGVSRTP
                     AREALTRLAGENLLEKIPNKGFVVKEFQEKEKLDTYSVIGVLDALAGSSALQNLTESD
                     LVKMEELTEMMAVSIKYKNHNSYLKLSNEFHDIYITKSDNQVLVNLLNSLRYNFMSKS
                     YTSDNEDELYKMLTYSNNQHIEVVKSMRENDLENVERILREHWKTIPIAEMKKEKLL"
     gene            complement(1006..2871)
                     /locus_tag="KR257_003473"
     CDS             complement(1006..2871)
                     /locus_tag="KR257_003473"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728711.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycoside hydrolase family 13 protein"
                     /protein_id="HBH0032133.1"
                     /translation="MQSVIEYNSWDKNFKAPFGALKFDEELTICVKVNEGYNIKSISL
                     EINREEEMRTITLNEELDNDKLGKCFCGKIEKFDGTGVYFYYFKVDVEMDGQIKTLFY
                     GKNRDNGYSCEYNYSDINKYQITVYKDFKVPTWYKEGILYHIFVDRFNNGNRSGKVDN
                     PKKNSFIYGNWEDTPMYIKDSQGDVIRWDFHGGNLRGIINKLGYLKKLGVSILYLSPI
                     FEASSNHKYDTGDYKKIDPMFGDEDTFKELIDKAKEKGISIVLDGVFSHTGADSKYFN
                     MYGNYNSLGAYQSKESPYYSWYMFEEFPQKYKSWWDVKTLPNINELEHSYMDYIIYDN
                     DSVINKWVNMGIKGWRLDVADELPTKFIRELKKELKKADDDSILIGEVWEDASNKISY
                     GQRRSYLLGEELDSVMGYPFRNNMFSFLKGEINSYELCNRYMQIKENYPKESFRSNLN
                     LIGTHDVTRAKTELNDDVDLVKLAVAIQMTFEGVPYIYYGDEAGLCGGVDPDNRRTYP
                     WKNEDEDMLNFYRDVIKIRNKNKLLSSGNTEFIYTNNDSVFSFIRVNENNDRMLILVN
                     RSENVESISLCIESSFIEEIPIKYSLKNANSTIQIENNELKVDLDSKSFRIFRVN"
     gene            complement(2876..5296)
                     /locus_tag="KR257_003474"
     CDS             complement(2876..5296)
                     /locus_tag="KR257_003474"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895917.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycogen/starch/alpha-glucan phosphorylase"
                     /protein_id="HBH0032134.1"
                     /translation="MVTISKKKFKQKFEVKMYSLYAQSIKEATDEQLLNVLCSLLKDE
                     IAKKWVATKLDKKKEVYYFSLEFLIGRQLKSNLLNLNIEEEVREGLSELGINLDDLIE
                     TEVDPALGNGGLGRLAACFLDSMASLNISGQGYGIRYKYGLFEQKFVNGYQVEVPDNW
                     LTEGRYAWETVRPNEATMVKFGGEVELIKEGSHLKVIHKNYLPVMAMPYDIPIIGYQN
                     QCINTLRLFKSEIPKRDFGELTSNALNYSGSYEEALKHKYYTEEISQVLYPDDSNYAG
                     KLLRLKQEYFFVSAGIQDIIRKYKKNKLNINNLFDKVAIHINDTHPTLCIPELMRILL
                     DEENLSWDEAWEITKKTVSYTNHTIMSEAMEKWPVSMMKELLPRIYMIIEEINRRYVE
                     ELNNKGYDQDRIKRMSIIDCDNINMANLCIVTSHSVNGVAKLHTHILETEVLKDFYQD
                     EPNKFNNKTNGIAHRRWLISSNPQLSNLITDLIGDSWKKDTLQLKNIEKFKNDSSVLQ
                     RLDDIKYNNKANLAKFIKDKYDLNVDPSSIFDVQVKRLHAYKRQLLNIFNVLHMYHEL
                     LDNPNLNLDPRTFIFGAKAAPGYYLAKCIIKFINSVASTINNDVRVKDKLKVVFLENY
                     GVSLAEIIIPAANVSEQISTTTKEASGTSNMKFMMNGAITLATLDGANVEICEQVGKE
                     NMFLFGLSAEQVLNYNKYGGYSSLDLYHSNMDIKRVVDDLINGFIPNLGEEGRSIYNS
                     LTTYNDEYFVLRDFENYGQAQADINRLYRDKEKWNKMSLVNIANSGFFSSDRTISEYA
                     KDIWFKRV"
     gene            complement(5310..6752)
                     /gene="glgA"
                     /locus_tag="KR257_003475"
     CDS             complement(5310..6752)
                     /gene="glgA"
                     /locus_tag="KR257_003475"
                     /EC_number="2.4.1.21"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011053260.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycogen synthase GlgA"
                     /protein_id="HBH0032135.1"
                     /translation="MKVFYVTAECWPFAKTGGLGDVSYALPKELKKEGVDVRVIMPKY
                     STIPSYLKDQLKEIAVFSVRVGWRNQYCGLLEMELDGVKFYFIDNEFYFRREDERKSI
                     YGYGDDAERYTFFTDAVLEAISRIDFYPDVIHINDWHTGMLPLILKERYATLEGYKNI
                     KTMYTIHNLQYQGVFDKHVLYDILDLPQKYFDNGDIEYYGSINFMKAGINFADKIITV
                     SPTYANEIQTSFYGEQLDGLLRKESGKLKGILNGIDYDLNDPAKDKDIFVHYDVDSID
                     KKVENKLRLQDILGLKKDSSIPLIGIVSRLVSQKGFDLIAYMMPELMREDLQIVVLGT
                     GEHQYQSMFNYYDSNFSDKVSARITFNASLAQQIYAASDMFLMPSLFEPCGIGQMLAM
                     RYGSLPIVRETGGLRDTVTPYNKFTGEGNGFSFKNYNAHEMFFCLKNAIKVFKDKEKW
                     IKLVENAMKTDNSWKKSAKEYIETYRDICD"
     gene            complement(6781..7911)
                     /gene="glgD"
                     /locus_tag="KR257_003476"
     CDS             complement(6781..7911)
                     /gene="glgD"
                     /locus_tag="KR257_003476"
                     /EC_number="2.7.7.27"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004453566.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glucose-1-phosphate adenylyltransferase subunit
                     GlgD"
                     /protein_id="HBH0032136.1"
                     /translation="MRNECLGIINLNKKGDPAINKLNYGRPIASTPIAGRYRIIDFAL
                     SNMINSGITKVGIFAKEKYRSLTDHIGSGKDWDLSRKKGGLSIFSPENTKYRNTYSHR
                     EGDIYTILANLDYIEKSEEEYILIAPSYMLCNLNYSQALEYHKKSHNDITIIYKNVNN
                     ANKDFAGNLTLNLDSNNRVINVGNNLGKFPRANICMETYIMKREDFVECIYNIVNKGN
                     YCYLEEFIIEEAENMKIGAYEYTGYLKCVNSVESYFEMSKDLLNLEVADELLYSERKI
                     FTKEKNESPTIYTDSAKVENSFIASGCLIEGTVKDSIIFRKVNVEKGTVIENSIVMQN
                     CVIKSNAKLYNAILDKNTSVSNGKELRGDEKYPLVVEKNTNI"
     gene            complement(7913..9073)
                     /locus_tag="KR257_003477"
     CDS             complement(7913..9073)
                     /locus_tag="KR257_003477"
                     /EC_number="2.7.7.27"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892825.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glucose-1-phosphate adenylyltransferase"
                     /protein_id="HBH0032137.1"
                     /translation="MKKEMLAMILAGGQGSRLGVFTKRIAKPAVSFGGKYRIIDFVLS
                     NCSNSGIDTVGVLTQYRPLILNSHIGMGSHWDLDRINGGVYVLQPFMNEKEGNWYNGT
                     AHAIYQNMDFVDTYNPEYVLILSGDHIYKMDYSKMLKFHKEKGSKATIAVIEVPWDEA
                     SRFGIMNTNEDSSIYEFEEKPSEPKSNLASMGVYIFDWKMLRNYFKEAEKNPEINYDD
                     FGKNLIPKMLEDNVGMYAYPFKGYWRDVGTIQSLWDANMDIIKSPETLDLADPKWKIY
                     TNTMAMPPQYIGKNANVHRSMIADGCRILGEVGNSVLSHGVVVGKGSKVIDSVIMPNV
                     VIGENVTIEKAMIGECATINDNVQIKNVNNEINVVSEYENIEPRCVLIEGGL"
BASE COUNT         2942 a         1707 c          912 g         3763 t
ORIGIN      
        1 gtagtgcctt agagttttta tttgtattta aagttaaatt tattcttgtt tttcctttaa
       61 tatttaatag taaaacaaca aaattataaa aaaaataaag agaaacttta taaaagcttc
      121 tcttttttca tctctgctat aggtatcgtt ttccaatgtt ctctcaaaat tctttcaaca
      181 ttttctaaat cattctccct catagatttt actacttcaa tatgttgatt attgctgtat
      241 gtcaacattt tatataactc atcttcatta tcactagtat atgactttga cataaaatta
      301 tatcttaaag agttcaatag atttactaac acctgattat ctgatttagt tatgtatata
      361 tcgtgaaatt cattacttaa ttttaaatag ctattgtgat ttttatactt tatagagacc
      421 gccatcattt ctgttaattc ttccattttt actaggtctg attcagttaa attttgtaat
      481 gctgaagaac cggctaacgc atccaatact ccaattacgg aataggtgtc taatttctcc
      541 ttttcctgaa attcttttac tacaaatccc ttattaggta ttttttctag taaattttca
      601 cctgctaacc tagttaatgc ttctctcgct ggtgttctac taactccgat agatttacaa
      661 atctcagatt cagtaattct ctgattagct tcatattctc cattttggat tttctttgat
      721 atatagtcat atacttgagt tgtaagtgga tctaccttca taagacgttc ctccatatta
      781 agattataaa agttaaatct ccctacaact ttggtagaga gttcagtttt atcttactaa
      841 tttatataat atcacaatta tgatattttt tatacttctt tgtaatattt tgaaatacta
      901 aaattcttat gataatttat acaaaaaaag tagaaaaagt tttgataaaa caaaactctt
      961 tccacattcg ccttattttc tatttatttt tctaaaaaaa gatatttaat ttactctaaa
     1021 aattctaaat gatttagagt ctaaatctac tttcaactca ttattttcaa tttgtatagt
     1081 actatttgca tttttaagac tatactttat aggtatttcc tcaataaaac tactctctat
     1141 acataatgat atactttcca cattttcact tctatttact aaaattaaca ttctatcatt
     1201 attttcatta actctaataa aagaaaatac agaatcatta ttagtatata taaattctgt
     1261 atttccagaa cttaaaagtt tattcttatt tctaattttt ataacatctc tataaaaatt
     1321 aagcatatct tcgtcttcat ttttccatgg ataagttctt ctattatctg gatcaacacc
     1381 tccacaaaga cctgcttcat ctccataata tatatatggt actccttcaa atgtcatctg
     1441 tatagctaca gcaagcttca ctaaatctac atcatcattt aattccgttt tagctcttgt
     1501 aacatcatgt gttccaatta aatttaaatt agacctaaat gattcttttg gataattttc
     1561 tttaatctgc atatatctat tacaaagttc atatgaatta atttctcctt ttaagaaaga
     1621 aaacatgtta tttctaaaag gataacccat aacagaatct aattcttcac ctaataaata
     1681 acttcttctc tgaccatagc taatcttatt tgatgcatct tcccatactt cacctataag
     1741 aattgagtca tcatctgcct tttttaattc cttttttaac tctcttataa acttagttgg
     1801 taattcgtct gcaacatcta gtctccagcc cttaataccc atatttaccc atttatttat
     1861 aacgctatca ttgtcatata ttatataatc catatagcta tgttctaatt catttatatt
     1921 tggcaatgtc ttaacatccc accaactttt atatttttga ggaaattctt caaacatata
     1981 ccatgaataa tatggagatt ctttagattg atatgctcct aaactattat agtttccata
     2041 catattaaaa tatttactat ctgctccagt atgactaaaa actccatcta atactattga
     2101 tatacctttt tcttttgctt tatcaataag ttctttaaat gtatcttcat ctccaaacat
     2161 tgggtcaatt tttttatagt cacctgtatc atacttatga ttactagagg cttcaaatat
     2221 agggcttaga tatagtatac ttacacctaa tttttttaaa tatccaagtt tattgattat
     2281 ccctcttaaa tttccaccat ggaaatccca tcttataaca tccccttgac tatcctttat
     2341 gtacataggt gtatcttccc aatttccata tatgaaacta ttttttttag gattatcaac
     2401 cttaccacta cgatttccat tattgaatct atctacaaat atatgataaa gtattccttc
     2461 tttgtaccat gttggtactt taaaatcttt ataaacagtg atttgatatt tattaatatc
     2521 actataatta tattcacaag aatatccatt atctctgttt tttccataaa ataaagtctt
     2581 tatttgacca tccatttcaa catcaacttt aaagtaataa aaataaacac ctgtaccatc
     2641 aaacttttca atcttaccac aaaagcactt tccaagttta tcattatcta attcttcatt
     2701 taaagttatt gttctcattt cttcttctct atttatttct agggaaatag acttgatatt
     2761 gtatccctca tttactttaa cacaaatggt caattcctca tcaaatttta aagctccaaa
     2821 cggagcctta aaatttttat cccaagagtt atattctatt acactttgca tttaatcaca
     2881 cccttttaaa ccaaatgtct tttgcatact cagaaattgt tctatcagaa gaaaaaaatc
     2941 cagagttagc tatattaact aaagacattt tattccattt ttctttatct ctatataacc
     3001 tgtttatatc tgcttgagct tgaccataat tttcaaaatc tctcaataca aaatactcat
     3061 cattgtaagt agtgagtgaa ttataaatac ttcttccttc ttcgccaaga ttaggaataa
     3121 atccatttat taaatcatct actacccttt ttatatccat attagaatga tataggtcaa
     3181 gtgaagaata tccaccatat ttattataat ttagtacttg ttctgcacta agtccaaata
     3241 aaaacatatt ttctttacca acctgttcac atatctctac atttgcaccg tcaagtgtag
     3301 ccaaagttat agcaccattc atcataaact tcatattact tgttccagat gcttccttag
     3361 ttgtagttga aatttgctca ctaacatttg ctgctggtat tattatttct gctaatgata
     3421 ctccataatt ctctaaaaat actactttta acttgtcctt tactctaaca tcattattta
     3481 tagtacttgc aacagaattt ataaatttaa ttatacattt agccaaataa tatcctggtg
     3541 ctgcttttgc gccaaatata aaagttcttg ggtcaagatt caaattagga ttatcaagta
     3601 attcatgata catatgaagt acattaaata tattcagtaa ctgtctttta tacgcatgca
     3661 atctcttaac ttgaacatca aatatcgaac ttgggtctac atttaaatcg tatttatctt
     3721 ttataaactt tgctagattt gctttattat tgtattttat atcatcaagt ctttgtaaaa
     3781 cagaggaatc atttttaaat ttttcaatat tttttaattg taatgtatct ttcttccatg
     3841 aatcaccaat taaatctgta attaaattgc taagttgagg atttgaactt ataagccatc
     3901 gcctatgtgc aattccatta gtcttattat taaatttatt tggttcatct tgatagaaat
     3961 cttttaatac ctctgtttca agaatatgag tatgaagctt agcaactcca tttacactat
     4021 gacttgtgac aatacataag tttgccatat tgatattgtc acagtctatt atactcattc
     4081 tttttattct atcttggtca tatcctttat tatttaattc ctctacatat cttctattta
     4141 tttcttctat tatcatataa attcttggta atagctcttt catcatactt acaggccatt
     4201 tttccattgc ttctgacatt atagtatgat tagtatagga cactgttttt ttagttattt
     4261 cccatgcttc atcccaagat aaattttctt catcaagcaa aattctcata agttctggta
     4321 tgcataaggt aggatgtgta tcatttatat gaattgctac cttatcgaat aaattattaa
     4381 tatttaattt gttcttttta tattttctta ttatatcttg tatccctgca cttacaaaaa
     4441 agtattcttg tttcaacctc aacaacttac ctgcatagtt tgaatcatca ggatataata
     4501 cctgtgatat ttcctcagta taatacttat gttttaaagc ctcttcatag ctaccagaat
     4561 aatttagagc atttgaggta agttcaccaa aatctctctt tggtatttca ctcttaaaca
     4621 atcttaaagt atttatacat tggttttggt atccgattat tggtatatca taaggcattg
     4681 ccattacagg aaggtagttt ttatgaatta cttttaaatg actaccttcc ttgattaatt
     4741 ctacctcacc accaaacttc accattgttg cttcatttgg tcttacagtt tcccatgcat
     4801 atcgtccttc tgtaagccag ttatcaggca cttctacctg ataaccattt acaaattttt
     4861 gttcaaacag accatattta taccttattc catatccttg accacttatg ttcaaagatg
     4921 ccatagaatc taaaaagcaa gctgctaatc taccaagtcc accatttcct aaggctgggt
     4981 ctacttcagt ttcaattaaa tcatccaagt tgattcctaa ttcagataaa ccttctctaa
     5041 cttcttcttc aatatttaaa tttaataaat tagattttaa ctgtctccct attaaaaatt
     5101 ctaaactaaa ataataaact tcttttttct tatctaactt tgtagcaacc catttttttg
     5161 ctatctcatc tttcaataga ctacataata catttaacaa ttgttcatca gtagcttcct
     5221 tgatagattg tgcatataag ctatacattt ttacttcaaa tttttgcttg aatttctttt
     5281 tgcttattgt taccaaaaaa accactcctt taatcacata tgtctctata tgtttctata
     5341 tactccttag ctgatttttt ccaactatta tctgttttca ttgcattttc aactaattta
     5401 atccattttt ctttgtcctt aaatactttg attgcatttt tcaaacagaa aaacatctca
     5461 tgagcattgt aatttttaaa actaaatcca ttgccttctc cagtaaattt attataaggt
     5521 gttactgtat ctctaagccc tccagtctct ctaactattg gtaaagaacc atatctcata
     5581 gctaacattt gacctatacc acaaggctca aataatgatg gcattaagaa catatcactt
     5641 gcagcatata tctgttgagc caatgatgca ttaaaagtaa ttctagctga tactttatct
     5701 gaaaaattag aatcgtaata gttgaacatt gattgatatt gatgttctcc agttcctaaa
     5761 acgacaatct gtaaatcttc tctcataagt tctggcatca tgtatgctat taaatcaaat
     5821 cctttttgag aaactaatct cgaaactata cctatcaacg gaatagatga atctttttta
     5881 agtcccaata tatcttgtaa tctcaattta ttttctactt ttttgtcaat tgagtctaca
     5941 tcataatgaa caaatatatc tttatctttt gcagggtcat ttaaatcata atctatacca
     6001 tttaatatac cttttaattt tcctgactct tttctaagta atccatctaa ttgttcacca
     6061 taaaaagatg tttgtatttc atttgcataa gtaggactaa cagttataat tttatctgca
     6121 aaatttatac cagctttcat aaaatttatt gagccataat actctatatc tccattatca
     6181 aagtattttt gtggtaagtc caatatatca tataaaacat gcttatcaaa tacaccttga
     6241 tattggagat tatgtatagt atacatagtt tttatatttt tatacccctc aagggttgca
     6301 tatctttctt ttagaattaa tggtaacatc cctgtatgcc aatcatttat atgtattaca
     6361 tctggataaa aatcaattct acttatagct tctaaaactg catctgtaaa gaaagtatat
     6421 ctttctgcat catctccata tccatagata ctctttcttt catcttctct tctaaaataa
     6481 aattcattat ctataaagta aaattttaca ccatctaatt ccatttctaa aagaccacag
     6541 tattgatttc tccatccaac acgtacacta aacacagcta tttcttttag ttgatctttt
     6601 aaataacttg gtatagttga atatttgggc attattaccc ttacatctac accttctttt
     6661 tttaattctt taggcaatgc ataagaaaca tctcctaatc ctccagtttt tgcaaagggc
     6721 caacactctg ctgttacata aaaaaccttc attagtcatt cccccttcta aaaaatttat
     6781 ttatatattt gtattctttt ccactacaag aggatatttt tcatctcctc ttaattcttt
     6841 cccatttgat acactcgtat ttttatctaa tattgcatta tatagttttg catttgactt
     6901 tattacacaa ttttgcatta ctattgagtt ctctataact gttccttttt caacatttac
     6961 ctttctaaat atgatactat cttttacagt accttctatt aaacaaccag atgctataaa
     7021 gctattttct actttagcac tatctgtata aattgtaggt gattcattct tttcttttgt
     7081 aaatatcttt ctttcagaat ataataattc atctgcaact tctaaattta ataaatcttt
     7141 gctcatttca aaatatgatt caacagaatt tacacatttt agatatcctg tatattcata
     7201 ggctcctatt ttcatatttt ctgcttcttc aataataaat tcttctaaat aacaataatt
     7261 gcctttattt acaatgttat atatacattc aacaaaatct tcacgcttca taatatatgt
     7321 ctccatacat atgtttgctc tagggaactt acctaaatta tttcctacat ttattaccct
     7381 attgttacta tctaaattta gagttaagtt accagcaaaa tctttatttg cattatttac
     7441 atttttatat attatagtta tatcattatg agatttttta tggtattcca atgcttgaga
     7501 ataatttaaa ttgcatagca tatagcttgg agctattaaa atatattctt cttcactctt
     7561 ttctatataa tctagattag ctaagatagt atatatatca ccttctctat gtgagtaagt
     7621 atttctatac ttagtgtttt ctggactaaa aattgatagg ccaccttttt ttctacttaa
     7681 atcccaatct ttaccactac ctatatggtc tgttaatgat ctgtattttt cttttgcgaa
     7741 tattccaact ttagtgattc ctgaatttat catattagat aaagcaaagt ctattattct
     7801 atatcttcca gctattggtg tagatgctat tggtcttcca tagttaagtt tgtttattgc
     7861 tgggtctcct tttttgttta aatttattat ccctaaacat tcatttctca tcttaaagac
     7921 ctccttctat taatacgcat ctaggttcga tattttcata ctcagaaact acatttattt
     7981 cattatttac attctttatc tgaacattat catttatagt tgcacactca cctatcatag
     8041 ctttttctat agttacattt tcacctatta caacatttgg cattattact gaatcaatta
     8101 ctttacttcc tttaccaaca acaactccat gtgataatac agagttacct acttcaccta
     8161 aaattctaca accatcagct atcattgatc tatgaacatt tgcattttta cctatatatt
     8221 gtggaggcat tgccatagta tttgtatata tcttccactt agggtctgct aaatcaagtg
     8281 tttctggaga ttttattata tccatattag catcccatag actttgtata gttcctacat
     8341 ctctccagta tcctttaaat ggataagcat acattccaac attatcttct aacattttag
     8401 gtattaaatt ttttccaaaa tcatcataat ttatttctgg atttttttct gcttccttaa
     8461 aataatttct caacattttc caatcaaata tgtatactcc catagatgcc aaattgctct
     8521 taggttcact tggtttttct tcaaattcat agatacttga atcttcattt gtattcatta
     8581 tcccaaatct tgaagcttca tcccaaggaa cttcaatcac tgctattgta gctttagagc
     8641 ctttttcctt atgaaatttt aacattttgc tataatccat cttgtatata tggtcaccag
     8701 ataatatcaa tacatattct ggattatagg tatctacaaa gtccatattt tgatatatcg
     8761 catgtgctgt accattatac caatttcctt ctttttcatt cataaatggt tgtaaaacat
     8821 agacaccacc atttattctg tccaaatccc aatgacttcc catgcctata tgtgaattta
     8881 atatcaacgg tctatattga gttaaaacac ctacagtatc aataccagag tttgaacaat
     8941 tgcttaacac aaaatctata attctatact tacctccaaa tgatacagct ggtttggcaa
     9001 ttctttttgt aaaaacacct aatcttgaac cttgccctcc tgccaaaatc atagctaaca
     9061 tctctttttt catttaatga cactcccctc atctagtaat taatatttat aattgcattt
     9121 ttacttttat aaactttatc agtcaataaa tgtcgtgtat aaatgttgct taaataatac
     9181 cttaataaaa ataaaataat atcaactata caattgatat aatgtatacc ccataatgga
     9241 cttaccgacg tatacattat tttccataag cactatagta tttattaata ttcaattatt
     9301 ggttaaaaaa taatacaaat ttta
//
LOCUS       DAEPID010000117         9224 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.118, whole genome shotgun sequence.
ACCESSION   DAEPID010000117 DAEPID010000000
VERSION     DAEPID010000117.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 9224)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 9224)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..9224
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.118"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            151..1350
                     /locus_tag="KR257_003478"
     CDS             151..1350
                     /locus_tag="KR257_003478"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436472.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0032138.1"
                     /translation="MKLKSKISILIIFLTLAIYFSIGLLNNEDNLKIKTIKGDSNELD
                     HININFGYALNGYINSYYTINGSNKTKKTELIKLQKDSKNTNNLIDVSSGSDLIAHVG
                     FEMNEESKDINFVIDEKKEDLEKGVFPSEDSDKEIEYEKLDMNNFTRTRYKVDKSTDD
                     YYAKILSSKRYKKYLYVSVLYATSDSSENNKEYSSTIDIIKINPENKKIKTIKSINLS
                     NYFSEKYQNIENIGVSYASKYEDKMYILVNVLNTNIGDNSNSKFHLLEYNLEENKESI
                     MELKTDSKMALAKAKLEANKLYMVMSNDYDNSSITELNLLTYNILDKSLDEDKYVLDN
                     REKRGIRSIEIDSNKIVAYTSRLNSILSWDDKFMLYIINKNSKEIVYEGELQFNSSNS
                     MLEFEIK"
     gene            1359..2171
                     /locus_tag="KR257_003479"
     CDS             1359..2171
                     /locus_tag="KR257_003479"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430030.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0032139.1"
                     /translation="MKDLIRLFEFELKRNIKNYIFIIICCCSFVILNIVKNLNDYNYI
                     IENAVKSEQLTKIGNTIETVNVTGFSSFRNIMGSTELWFMFGIIACICYAFFIWYRDF
                     NGRSKSIYTLIMLPKNRINIYISKLLNILFLVYSYTVVLTISLFIASKLLPRHMLGNV
                     TNYGFVQETIYELKMLLPYSFEILFVEYIFLLIGFVSVVFTSILINKSIYKVSTLISF
                     LFLVIEILVFIISIEFIIPYEYSDVFTVLYSSINIFVCSLISNKLLKQKIDF"
     gene            2182..3450
                     /locus_tag="KR257_003480"
     CDS             2182..3450
                     /locus_tag="KR257_003480"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861271.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0032140.1"
                     /translation="MKAKNIGKYTICFIIVCFLMITMTLILSYFNKDKLSVKTLKGNV
                     KDIGRVSVVYTPNISKFSYEEVIISKNGVRNNTNPKSRIRNDYLNIDKKYSDFVNDKG
                     KEFIYKDDLNIGEAYTSVKSDLVQGMNALNDCIKVSNKNLKSGVEENFDINLNKSDFK
                     ENSWKTLFNKIYKGNLYMVISETNISGSKVNNICILKIDIKNKSYKLLNRFNLGLQNG
                     EQQNINEIKFSIGSKLYLEIVNNKSKNGYIEGHDSYSNFIIYDIEDNTFNISNKFMDN
                     LNKEKNANPKEIGLLSKTKLDYMVKNNKLNLIVTDMSNSITNLVYDINSNEIKLEDYE
                     ILDLKVDYNEASSGVRKVKLLDDKIYSISGIKNSISGELKGFKGIVDVVGTKPVKFQV
                     FDMKLKKNIYEAELINGDISLQEKLFFVAN"
     gene            3816..4997
                     /locus_tag="KR257_003481"
     CDS             3816..4997
                     /locus_tag="KR257_003481"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430033.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amidohydrolase family protein"
                     /protein_id="HBH0032141.1"
                     /translation="MNKKYIKAGNLIDGTGNSIMQNKGIIIDGDTIVEIEDIRDDLNG
                     YDVYDYLDKTVMPGIMNCHVHLTMEPVGNPKIYYDNVSDVELVVNTIKQLDAYLDSGV
                     TYIRSLGCPKYVDVQLKNLIDKGSIDGPGIVTSGPVICMTGGHGYYFGIESDGVDECR
                     KSARTVLKNGVDCVKIMATGGVTTDGVEPGSPQLTLEEMKAAVDEAIKAGKITATHAQ
                     GRTGIKNAVLAGITSIEHGVYLDDEIIDLMLERGTYLVPTVAAPYFILNAGKESGITE
                     ATLRKCEIVAIPHKESFLKAYKKGIKIAVGSDAGTSYNEHGKTYYEMKLMSDYGMDNM
                     DIIVAATKTASELLRIDKNYGTLEKGKKADVIVVNGNPVENIDVLADVLAVFKLGKKV
                     R"
     gene            complement(5139..6056)
                     /locus_tag="KR257_003482"
     CDS             complement(5139..6056)
                     /locus_tag="KR257_003482"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436448.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0032142.1"
                     /translation="MENNKCREDFRFTQEYEEDYPNTNERYYENYQVADRYYNYPNKY
                     KEPKIKQCCCKKSMREALELLRYDALRPFVNFNQFAFISDFFIVGANLVGIDLSAPPK
                     DNLSGLDGTFERFSACNCDLIDIAGRVSYPIPVPLTLEGLINTIGTIPGVAELIALID
                     AVIPPTIDLGAILDAILAAIIDFILAASTPLANVDLASLCNLKAVAFDITPADYEDFI
                     ASLGYYLDKKHYKECNCNCDCDDCCCNKGILDNLYMSNINNQVTVVAGSLVLTGVEVL
                     GKKNDVIVLGNSNDSRIYFVCVDSIDYIA"
     gene            6309..7103
                     /locus_tag="KR257_003483"
     CDS             6309..7103
                     /locus_tag="KR257_003483"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436445.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBH0032143.1"
                     /translation="MIEVDKLCKSFTRVVKDDKNKSSIRKLKKVKTKKEEFFAVNNVS
                     FKVMEGEIVGILGPNGAGKTTLLRMLGGILTPTSGSINISGYDYSIDRNSAKKEIGYL
                     SGNTKLYGRLSPRELLTTFASLYEMSKEDIEESIENIVKIMDMSEFIDNRIENLSTGQ
                     TQRTSIARCLIHSPKVYIFDEPTLGLDVLSSASIIDFMKNEKLRGKTVLYSTHYMEEA
                     ETLCDKIFMIHNGKIIASGTPQSLKEESGVNNLRDVFIKLARKEDI"
     gene            7104..9164
                     /locus_tag="KR257_003484"
     CDS             7104..9164
                     /locus_tag="KR257_003484"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009905519.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CPBP family intramembrane metalloprotease"
                     /protein_id="HBH0032144.1"
                     /translation="MRSKIVKYIFKKEMLDILRDKKTLFMMIVVPLLLYPLLMLLMIQ
                     VMNMSASSMNSKDINIAFNNKPNKVLVSMIEDDNLEKDTKNTSNDKGKIRVLDVDNYK
                     KSLEENKIDAYIKMEEKKSSINYQIYINSSQENSSNALKRIETVLDKYKRFTIEKTLS
                     EKGLDVQATLEPITYSTVDVAKTEEVAGYFLGQILPFILIIGVLLGSIYPAIDVMAGE
                     KERGTLETLFTLPISNLELVMGKYMAVSLSAIVTAILNILSMGLTMAFILVSGGISSQ
                     FGFGNFNYGDLVLPIITTLICICLFSMVVSAISMCVCSLAKSFKDAQNYITPLMLIIM
                     IPSYVSMIPNIVLDRVTAVIPVVNISLLIKSVLSFKSDLNLIALVLASNVAFVILAII
                     LLSKMFNSEEILFGNSKSFSFLEKRSNIKKGSIPTVSDGVILYAVGLVLLIYVGSLVQ
                     IKFGMAGIIMTQFMIISLPLLFAYYIKADFKEVFSLKVPKLKHVFGSIVLWIGGYILI
                     MIITQLILFLFPQNMEVAESLNKALFIKDSVLLNLLAIALLPALCEEMFFRGFIFSSF
                     SKSKDKNKSIKLAIICSGVLFGIMHMDFIRIIPTSILGIIFAYSVYKSGSIFVSMLLH
                     FLNNSVAVVLNHYTTGNITNLYKFVEVDFSNLNVLKFALILLISLILIMLGLRVLDRK
                     SLRN"
BASE COUNT         3687 a          910 c         1458 g         3169 t
ORIGIN      
        1 cactttattt agaaaatatt ataatcttat aggatttcaa tttaacaatt tagtagcagg
       61 gttattaagt tttttaatta taatgtttat tctaaatgga atatcttatt tgctaattaa
      121 aaagaaagta tctctttaag gaggggtggt atgaaattaa aatctaaaat atctatactt
      181 attatatttt tgactttagc aatatatttt agtataggtt tattaaataa tgaagataat
      241 ttaaagataa aaactataaa aggtgactct aatgaattag accatataaa cataaatttt
      301 ggatatgctt tgaatggata tataaattca tattatacaa taaatggaag caacaaaact
      361 aaaaagactg aattaataaa actacaaaag gatagtaaga acacaaataa tttaattgat
      421 gtatctagtg gttcagattt aattgctcat gttggatttg aaatgaatga ggagtcaaaa
      481 gatataaact ttgtgataga tgagaaaaaa gaagatttag aaaaaggtgt atttccatca
      541 gaagatagtg ataaagaaat tgaatatgaa aaattagata tgaataattt tacaaggaca
      601 agatataaag tagataaaag tacagatgat tattatgcaa agatactatc atcaaaaaga
      661 tataaaaaat acttatatgt atctgtactt tatgctacaa gtgattcatc agaaaataac
      721 aaagaatatt caagtactat agatataata aaaattaatc cagaaaataa aaaaatcaag
      781 actataaaaa gtataaattt aagtaattat ttttccgaaa aataccaaaa catagagaac
      841 ataggtgtaa gttatgctag caaatatgag gataagatgt atattttagt aaatgtacta
      901 aatacaaaca taggtgataa tagtaattct aaatttcatt tacttgagta taatcttgaa
      961 gaaaataagg aaagcataat ggaattaaaa actgatagca aaatggcttt agcaaaagca
     1021 aagttagaag ctaataaatt atatatggta atgtcgaatg attatgataa tagttcaatt
     1081 acagagttaa atttacttac ctataatata ttagataaaa gcttagatga agataaatat
     1141 gttttagata atagagaaaa aagaggaatt agaagtattg aaattgattc aaataaaatc
     1201 gttgcatata catcaaggct aaactctata ttatcttggg atgataaatt tatgctatat
     1261 ataataaata aaaattctaa ggaaattgta tatgaaggag aattacaatt taacagttca
     1321 aatagtatgt tagaatttga aataaagtag gtgagttgat gaaagattta ataagattat
     1381 tcgaatttga attaaaaaga aatataaaga attatatatt tataataatt tgttgttgtt
     1441 cttttgtaat tttaaacata gtaaaaaatt taaatgacta taattacata atagaaaatg
     1501 cagttaaaag tgaacagtta acaaaaatcg gaaatacgat agaaacggta aatgttacag
     1561 gtttctcaag ctttagaaat ataatgggtt ctacagaatt gtggtttatg tttggtataa
     1621 ttgcatgtat ttgctatgct ttttttattt ggtatagaga ctttaatggt agaagtaaat
     1681 ctatatatac acttataatg ctacctaaaa atagaatcaa tatttatata tctaaattat
     1741 taaatatatt atttctagtg tatagctata cagtagtact tacaatatct ttgtttattg
     1801 caagtaagtt gttacctaga catatgcttg gtaatgtcac aaactatggt tttgtacaag
     1861 aaacaatata tgagttaaaa atgttacttc catatagctt tgaaatacta tttgtagagt
     1921 atatattttt attgatagga tttgtatctg tagtatttac atcaattctt ataaataaat
     1981 ctatttataa agtaagcact ttaataagtt ttctattttt agttatagaa attttagtgt
     2041 ttataatttc tatagaattt attatacctt acgaatacag tgatgtattt actgttctat
     2101 attcaagtat aaacatattt gtatgtagtc ttatatctaa taaacttttg aagcaaaaga
     2161 ttgactttta ggagggatat tatgaaagca aaaaatatag gaaaatatac aatatgtttt
     2221 ataatagtat gttttttaat gattactatg accttaatat tgagttattt taataaggat
     2281 aaactatctg taaaaacttt aaaaggcaat gtaaaagata tagggagagt aagtgtagta
     2341 tatacaccta atataagcaa attttcttat gaggaggtaa ttataagtaa aaatggagta
     2401 agaaataata caaacccaaa atcaagaatt agaaatgatt atttaaatat tgacaaaaaa
     2461 tacagtgact ttgttaatga taaaggaaaa gaatttatat ataaagatga tttgaatata
     2521 ggagaagcgt atacctctgt taagtctgat ttagtacaag gaatgaatgc tttaaatgat
     2581 tgtataaagg tttcaaataa aaatttaaaa agtggggtag aagaaaattt tgatattaat
     2641 ttaaataagt ctgattttaa agaaaatagt tggaaaacct tatttaacaa aatatataaa
     2701 ggtaatttat atatggtaat tagtgaaact aatatttcag gttctaaagt caataatatt
     2761 tgtatattaa agatagatat aaaaaataag tcttataaat tattaaatag atttaattta
     2821 ggattacaga atggagaaca acaaaatatc aatgaaatta aattttctat tggaagtaaa
     2881 ttatacttag aaatagtaaa taataaaagt aaaaatggat atattgaagg acatgatagt
     2941 tactctaact ttattatata tgatatagaa gataacactt ttaatataag taataaattt
     3001 atggataatc taaacaaaga aaagaatgca aatccaaagg agattggctt attaagtaaa
     3061 actaagctag attatatggt aaaaaacaat aaattgaatc ttatagttac ggatatgagt
     3121 aattccataa ctaatcttgt ttatgatatt aattctaatg agattaaatt agaagattat
     3181 gagatacttg atttaaaagt agattataat gaagcatcat ctggagttag gaaagttaag
     3241 ctactggatg ataagatata ttctatttca ggtattaaga acagtatatc aggagaatta
     3301 aaaggattta aagggattgt tgatgtagtc ggaactaagc cagtaaaatt tcaagtattt
     3361 gatatgaaac ttaaaaagaa tatttatgaa gctgagctaa taaatggaga tataagttta
     3421 caagaaaagt tattttttgt tgcaaattaa gtgttagaat taattttaga actttaaact
     3481 tttatatgta tcacagataa gtataagtaa gggagtgtct caaaataaac tttttagctc
     3541 atgagacact ttttttatat gaaatcaaat atattttcat tgtttagatt tattttgata
     3601 atgaaaaaaa gattatcttt attttaagaa agacatttat ttataattat atacaaaaat
     3661 attttttaat gtttttgtgt ataattataa caatttaatt tatattaatg cacttaaatt
     3721 tgaaatagaa tgcttatagt ggtaaaatta attattagaa tattagaaat aataaataaa
     3781 taatacattg tacttaaaag ggggagaaat ttaagatgaa caaaaaatat attaaagcag
     3841 ggaatttaat tgatggaacc ggaaatagta ttatgcaaaa taagggtata attattgatg
     3901 gagatactat agttgaaatt gaagatataa gagatgattt aaatggatat gatgtgtacg
     3961 attacttaga taaaactgtt atgccaggca ttatgaattg tcatgttcac ttgacaatgg
     4021 agccagttgg aaatccaaag atatattatg ataatgtatc agatgtagag cttgtagtaa
     4081 atacgataaa acaacttgat gcttatttgg attcaggagt aacatatatt agaagcttag
     4141 gttgtcccaa atatgtggat gtacaactta aaaatcttat agacaaaggg tctatagatg
     4201 gtcctggtat agttacttca ggtccagtta tatgtatgac aggagggcat ggatattatt
     4261 ttggtattga aagtgatgga gtggatgaat gtagaaaatc agccagaaca gttttaaaaa
     4321 atggagtaga ttgtgtaaag ataatggcaa ctggaggtgt aacaactgat ggagttgagc
     4381 cagggtcacc acaattaact ttggaggaaa tgaaggctgc tgtagatgaa gctataaaag
     4441 caggtaaaat aactgccaca catgcacaag gaagaactgg tataaaaaat gcagtgcttg
     4501 caggaattac ttctatagaa catggtgttt atttagatga tgaaataatt gatttgatgc
     4561 ttgaaagagg aacttactta gttccaactg tggctgcacc atattttatt ctaaatgcag
     4621 gaaaagaaag tggaataact gaagctactc ttagaaagtg tgagattgtt gccattccac
     4681 ataaagagtc attcctaaaa gcatataaaa aaggaattaa aattgcagtt ggttctgatg
     4741 caggaacttc ttataatgaa catggaaaaa catattatga aatgaaacta atgtcagatt
     4801 atggtatgga taatatggat ataatagttg ctgctacaaa aacagcatct gaacttttaa
     4861 gaattgataa aaattatgga actctagaaa aaggaaagaa agcagatgtt atagttgtaa
     4921 atggaaatcc agtagagaat atagacgtac ttgcagatgt gttagcagta tttaaacttg
     4981 gtaaaaaagt tagataaata gtataaaaat aaaaaagagt gtctaaagaa atttttaaat
     5041 aattatagac actctttttt attagtaata attaaatctt ttatacttta gaaaatagat
     5101 tctattttat atttagatat aactctttaa aatcattctt atgcaatata atctatagaa
     5161 tctacacata caaagtatat tcttgaatca ttagaatttc caagtactat aacatcattt
     5221 ttcttaccta gaacttcaac accagttaga accaaactac cagctactac agtaacttga
     5281 ttatttatat ttgacatata aagattatct aggatacctt tattacaaca gcaatcatca
     5341 caatcgcagt tgcaattaca ttctttgtaa tgttttttat caagatagta acctaaagat
     5401 gctatgaaat cttcataatc tgcaggtgta atatcaaatg caacagcttt aagattacac
     5461 aatgatgcta aatctacgtt tgctaatgga gtagatgcag caagtataaa atcaattata
     5521 gcagcaagta ttgcatctaa tatagcccca aggtctatcg taggaggaat aactgcatca
     5581 ataagtgcaa ttaattcagc tactcctggt atagttccta tagtattaat taatccctca
     5641 agagttaaag ggactggaat aggataagat actctaccag ctatatctat taaatcacag
     5701 ttacaagcag aaaatctttc aaaagtacca tcaagtccag ataaattatc ttttggagga
     5761 gctgaaagat ctatacctac caaattagca cctactataa agaaatctga gataaaagca
     5821 aattgattaa agtttacaaa aggtcttaga gcatcatatc ttagaagttc taatgcttct
     5881 ctcatacttt ttttacaaca acattgtttt attttaggtt ctttatattt atttggataa
     5941 ttatagtatc tatcagctac ttgataattt tcatagtatc tttcatttgt atttggataa
     6001 tcttcctcat attcttgtgt aaatctaaag tcctctctac atttattatt ttccactaaa
     6061 tacactcctt ttatatttta atttaaatgt atagataatt aagcttatct atatagtaat
     6121 attatattta taatgtaaaa aaatgttaca aaagatatta taaacgaata aaaaataata
     6181 atttgccaga taaacttgta aatttttatg aataatccat tctaaaacaa aaaactgtgt
     6241 ataaaaaagg tttatatgtt atatttatat aaatataaca tatgaacgag aaaggagtgg
     6301 tttgataaat gattgaggta gataaattgt gtaagtcttt tacaagggtt gtaaaagatg
     6361 ataagaataa aagttcaata agaaagctaa agaaagtaaa aactaaaaaa gaagaatttt
     6421 ttgctgtaaa taatgtttca tttaaagtta tggaaggtga aattgttgga atattaggtc
     6481 caaatggtgc aggaaagact acattactta gaatgttagg tggcatatta acaccaacat
     6541 caggaagtat aaatatttct ggatatgatt attcaataga tagaaattca gcaaaaaaag
     6601 aaataggtta tctctctgga aatacaaaac tatatggaag gctttctccg agagaacttc
     6661 taacaacttt tgcaagtcta tatgagatgt caaaagaaga tatagaagaa tcaattgaaa
     6721 atattgtaaa aataatggat atgagtgaat ttatagataa tagaattgaa aatctatcaa
     6781 ctggtcagac tcaaagaaca tctatagctc gttgtttaat acattctcca aaagtatata
     6841 tttttgatga gccaacacta ggtctggatg ttttaagtag tgcatctatt atagatttta
     6901 tgaagaatga aaaactaagg ggaaaaactg ttctttactc aactcattat atggaagaag
     6961 cagaaacttt atgtgacaag atttttatga ttcacaatgg gaaaataatt gcatcaggaa
     7021 caccacagag tttaaaagag gaatctggag taaataattt gagagatgta ttcataaaac
     7081 ttgccagaaa ggaggacatt taaatgagaa gtaagattgt aaaatacata tttaaaaaag
     7141 aaatgttaga catattgaga gataaaaaga ctttatttat gatgattgtt gtgccacttc
     7201 ttttatatcc tttacttatg ttattaatga ttcaagtaat gaatatgtct gcaagtagta
     7261 tgaatagtaa ggacattaat atagctttta ataataaacc taataaggtt ttagtatcca
     7321 tgattgaaga tgataattta gaaaaagata ctaaaaatac ttcaaatgat aaaggcaaaa
     7381 taagagtgtt agatgtagat aactataaaa agtcattaga agaaaataaa attgatgctt
     7441 atataaagat ggaagaaaaa aaatcatcta taaattatca aatatatata aattcttctc
     7501 aagaaaattc ttctaatgca ctaaaaagaa ttgaaactgt tttggataaa tataaaagat
     7561 ttaccataga aaaaacttta tctgaaaaag gattagatgt acaagctact ttagaaccaa
     7621 taacatatag cactgtagat gttgcaaaga cggaagaagt ggcaggatac tttttaggtc
     7681 agatacttcc atttatatta ataataggag ttttactagg ttcaatatat ccagcaatag
     7741 atgttatggc tggagaaaag gaaagaggta cattagaaac attatttaca ctgccaatat
     7801 caaacttaga actggttatg ggaaaatata tggcagtttc tcttagtgca atagtaacag
     7861 caattttaaa cattttatct atgggactga ctatggcatt tattttagtt agtggaggta
     7921 ttagtagcca atttggcttt ggaaacttta attatggaga cttagtctta ccaattataa
     7981 ctactttaat ttgcatatgt cttttttcaa tggtagtttc agcaataagt atgtgtgtat
     8041 gttcattagc aaaaagtttt aaagatgctc aaaactacat aacacctctt atgttaatta
     8101 ttatgatacc atcatatgtt tctatgatac caaatatagt attagataga gtgacagctg
     8161 taatacctgt agtaaatata tctttactta taaaaagtgt attatctttt aaaagcgatt
     8221 taaatttaat agccttagtt ttagcatcaa atgtagcctt tgttatattg gcaatcatac
     8281 tactgtctaa gatgttcaat tctgaggaaa tactttttgg taatagtaag agtttctctt
     8341 tcttagagaa aagaagtaat ataaaaaaag ggtctatacc aactgtaagt gatggtgtta
     8401 ttttatatgc agtaggatta gttctattga tttatgttgg ttctttagtt caaattaaat
     8461 ttggtatggc aggtattata atgacacaat tcatgataat ttctttaccg ttattatttg
     8521 catactatat taaagctgat tttaaagagg tatttagctt gaaagttccc aaattaaagc
     8581 atgtgtttgg gagcattgtt ctttggattg gtggatacat acttattatg attataacac
     8641 agctaatttt attcttattt cctcaaaata tggaagttgc tgaaagttta aataaggctc
     8701 tttttatcaa agatagtgtt ttactgaatt tactagcaat agctttatta ccagctttat
     8761 gtgaagaaat gttttttagg ggatttatat tttcttcatt tagtaaatca aaagataaaa
     8821 ataagtctat caagctagct ataatatgca gtggggtact atttggtatt atgcatatgg
     8881 attttattag aataattcca acatcaatat taggtattat atttgcatat agtgtgtata
     8941 aatctggttc aatatttgta tcaatgttat tgcatttttt aaataatagt gtagcagttg
     9001 tgttaaatca ttatacaact ggaaatataa ccaacttata taaatttgtt gaagttgatt
     9061 tttcgaactt aaatgtactt aaatttgcct taattcttct aataagtctt atattaatta
     9121 tgttaggatt aagagtttta gatagaaagt ctttaagaaa ttaagtataa agttattata
     9181 tagattaaaa tattaataag cactaaagta tatggatata tctt
//
LOCUS       DAEPID010000118         9089 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.119, whole genome shotgun sequence.
ACCESSION   DAEPID010000118 DAEPID010000000
VERSION     DAEPID010000118.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 9089)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 9089)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..9089
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.119"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            255..575
                     /locus_tag="KR257_003485"
     CDS             255..575
                     /locus_tag="KR257_003485"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424083.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Fe-S cluster assembly protein HesB"
                     /protein_id="HBH0032145.1"
                     /translation="MKITLPETAIDTLKSILKDNQDKPNNIRVYFAGVGCGGPSFGLA
                     LDEKKEDDLTYEVGELQFVMSSDEYSQYGDIIIEDTGFGFRVIPENMKDQGGGGCSGC
                     SGCH"
     gene            713..1357
                     /gene="trmB"
                     /locus_tag="KR257_003486"
     CDS             713..1357
                     /gene="trmB"
                     /locus_tag="KR257_003486"
                     /EC_number="2.1.1.33"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889910.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA (guanosine(46)-N7)-methyltransferase TrmB"
                     /protein_id="HBH0032146.1"
                     /translation="MRRRRKKGADEKLLSYTKYVLRDDIDKLKGKWNLKFRNDNPIHV
                     EFGTGKGKFITTLAKQNPDINYIAMELKEEVLLKAVEKADASNLNNILFLWGDVSNIL
                     DYFEAKELSRIYINFCDPWPKNRWSKRRLTHSGFLEMYNRVLEDDGEIHFKTDNEKLF
                     EFSLNEIAANNWLLKNISLDLGNSEYENNVTTEYEDKFMSQGMRIFRCEAKKRN"
     gene            1486..2232
                     /locus_tag="KR257_003487"
     CDS             1486..2232
                     /locus_tag="KR257_003487"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012816221.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0032147.1"
                     /translation="MWEGTMNLANLIPFIISAAALSPINSNDKVLSENQLKDIFPDAN
                     LRAVVKRYINPDEMTISNIKALDGEFYATGESISNLKGISYLENVDNFIFWNNNIKEI
                     PKEALSLKDMDSINLANNYLIDDDVVNSLSHNGVDVNCDLNFIDTKDNQYKLDSKYHN
                     VDIAKGESIDLRKIITKKIDSYYKYWEVTDNLPKDLNFIVSVSDKSVLSCEDMIIKGN
                     KTGQAVVKVILSDKNDLNTSQEVLITVNVK"
     gene            complement(2361..2639)
                     /locus_tag="KR257_003488"
     CDS             complement(2361..2639)
                     /locus_tag="KR257_003488"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424072.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0032148.1"
                     /translation="MVDTLEFGLKILFFILSIIWMGKIMILRTDKQIVINPLLIGISA
                     VLVMLHTSQSNIEFFGLDVQYIRIVLYIIYSLIILIGIWATNRRNGIF"
     gene            2914..3360
                     /locus_tag="KR257_003489"
     CDS             2914..3360
                     /locus_tag="KR257_003489"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435332.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0032149.1"
                     /translation="MESKFFNWYTQSLGGTFGIISCICAYLNGYMFVYTNSASKYFES
                     IGFLGIISSYTLLPLCMLTLIFGVIYSYTPETSDKSIFNIPFFTLNKRLILITVVFGF
                     IGARVYFIIPAILITFNLYSNVLIAKLKYILCKNKENDTNLKESEV"
     gene            3630..4082
                     /gene="accB"
                     /locus_tag="KR257_003490"
     CDS             3630..4082
                     /gene="accB"
                     /locus_tag="KR257_003490"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424068.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="acetyl-CoA carboxylase biotin carboxyl carrier
                     protein"
                     /protein_id="HBH0032150.1"
                     /translation="MNINEIKELLKAIDSTNLEYVKLESSDLRLEVSKKAQSTSSPVL
                     SVQQESVVDLSLEKPVVNDTPVTSNENLSVVVAPLMGTFYDSPSPDADSFVKVGDVVE
                     EGDTLCILEAMKLMNEITSEIKGEIIEVLVSNEELVEYNQPLFKIKPL"
     gene            4098..5459
                     /gene="accC"
                     /locus_tag="KR257_003491"
     CDS             4098..5459
                     /gene="accC"
                     /locus_tag="KR257_003491"
                     /EC_number="6.3.4.14"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424066.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="acetyl-CoA carboxylase biotin carboxylase
                     subunit"
                     /protein_id="HBH0032151.1"
                     /translation="MIKKILVANRGDIAVRIIRTCKELGIKTVAIYSEIDKDCFHRYI
                     ADESICIGPNNISKSYNNIENIIYLALKLKCDAIHPGFGFLSENPEFAKQCEDNNIIF
                     IGPTREQMILMGDKSRARETMMELNIPVVPGSESVLKTKEEALEVAREIGYPVMIKAS
                     SGGGGKGMRIVRKEEELFSNFDMASSEALAAFSNSDLYMEKFIENPRHIEVQVFGDKH
                     SNAIHLGDRDCSMQRRNQKVIEESLSPYLSDEERQKLHKIAVDIVKGVGYIGAGTIEF
                     IVDKDKNFYFIEMNTRIQVEHPVTEMVTNLDLIKLQISIANGDKIPFKQEDITFRGHA
                     IECRINAEDSSKNFAPSPGKIESLNLPGGFGVRFDTFVYAGYTIPPLYDSMIGKLICW
                     AETREECISRIYRALDEIIVEGINTNVEFQKALVTSEEFREDTHHTKFIEDVFMKKEF
                     ATL"
     gene            5474..6328
                     /locus_tag="KR257_003492"
     CDS             5474..6328
                     /locus_tag="KR257_003492"
                     /EC_number="6.4.1.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424064.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="acetyl-CoA carboxylase carboxyltransferase
                     subunit beta"
                     /protein_id="HBH0032152.1"
                     /translation="MIKKFLSSKESKYVTISLDDNFKKNSVDDKFWTYCKGCDSHVFR
                     KDIEENSFVCPKCSRHYGLRARKRINLLIDKGTFMEFNSDVEFQNPLNFPKYKEKVDS
                     YKEKTKESEAVVTGYGRINGIKTVICVMNPDFMMGSMGSIVGEKITYSIEYAAENNLP
                     IIICSASGGARMQEGMVSLMQMAKTSQALSKLEEKLLPYISVLTDPTTGGVTASFAML
                     GDIIISEPNTLIGFAGPRVIEQTINQKLPEGFQTSEFLLEKGFIDMIVDRRKMKEVLY
                     QILAMHKK"
     gene            6349..7293
                     /locus_tag="KR257_003493"
     CDS             6349..7293
                     /locus_tag="KR257_003493"
                     /EC_number="6.4.1.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424062.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="acetyl-CoA carboxylase carboxyltransferase
                     subunit alpha"
                     /protein_id="HBH0032153.1"
                     /translation="MIENNSEKIKVLENDIKQLITISKANNIDLSDKINSLNEKLEKL
                     KEDAFSHLSAYEKVTLSRDIKRPTTLEYIEHICSNFLELHGDRLFKDDPSMVGGIGQI
                     GKFNVTIVGHQKGRDTKENIKRNFGMPHPEGYRKALRLMKQAEKFNRPIITFIDTSGA
                     FCGLEAEERGQGEAIARNLLEMSKLSVPVITFVIGEGGSGGALGIGVGNDVCMLEHSV
                     YSVISPEGLSSILFKDSSKAKEACDVMKLTSNDLYDLKIIDKIIKEPLGGAQKDVEAV
                     SKEIKAYILERLNHYKDMDKEEIIAQRYKKFRNIGKCL"
     gene            7482..7742
                     /locus_tag="KR257_003494"
     CDS             7482..7742
                     /locus_tag="KR257_003494"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003866776.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="stage V sporulation protein S"
                     /protein_id="HBH0032154.1"
                     /translation="MEVLKVSSKSNPNSVAGALAGVLRERGVAEIQAIGAGALNQAIK
                     SIAIARGFVAPSGMDLVCIPAFTDIEIEGDKKTAIKLIIEPR"
     gene            7895..8266
                     /locus_tag="KR257_003495"
     CDS             7895..8266
                     /locus_tag="KR257_003495"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889900.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ACT domain-containing protein"
                     /protein_id="HBH0032155.1"
                     /translation="MKLKLLVEEYAVCRLNNDSKIPTWIDTEKFYSITRTDDELSVVC
                     LNNNIPSDVKSEKEWRILKILGPLDFSLVGILSKLSSLLADNKISIFAISTYDTDYIL
                     VKEKDIENACKILSCNGYEVE"
     gene            8296..>9089
                     /locus_tag="KR257_003496"
     CDS             8296..>9089
                     /locus_tag="KR257_003496"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424033.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0032156.1"
                     /translation="MIYIIEILKISVINIFCFIGIFIVFGLIFSITENLNNKFIFSSF
                     GKTGIIVTGAIGTFVHELSHLIMCLIFMHKINSVKFFRPIESKNDGILGYVSHSYKKD
                     NLYQSIGNFFIGIAPIIGGTIMIILIFKILLPDSYMKVTQNIDLKLYVSMINNLNING
                     FIHIILGDISNFIRIMLLTPSVYSLKYFIFMFLMYSISTHMSLSSADLKNSLNGLSFI
                     VIVIFVISSITYLFGFDNLNISSLIVKYNIFISFFMAIGFIFSIVTL"
BASE COUNT         3533 a          941 c         1534 g         3081 t
ORIGIN      
        1 attatcaaat gtgttataat attaaaacaa caaataaaat tattatattt tttagaataa
       61 taattttatt tgtttactaa gtttatgata gggtatttat ttaaggtaat aaaatattat
      121 ataaaatatt ttaaagcctt aggtaatatt aggtagaagt tttagtaaaa tatgcaaaaa
      181 ctaattgatt atgtaccttg tatgggtata taatagatat tgttttaata aaatatttga
      241 aagggaatga tttgatgaaa attactttac cagaaacagc tattgatact ttaaaaagta
      301 tcttaaaaga caatcaagat aaacctaata atataagagt atactttgca ggtgttggtt
      361 gtggaggtcc ttcttttgga ttagctttag atgagaaaaa agaagatgac ttaacttatg
      421 aagttggaga attacaattt gtaatgagct ctgatgaata tagtcagtat ggagatataa
      481 taatagaaga tacaggattt ggatttagag ttattcctga aaatatgaaa gatcaaggtg
      541 gaggaggatg ctctggttgt tcagggtgcc actaagatta agtttttagt aagtttagaa
      601 ctctctttat agaaataaat ttctatttta agagagttct ttttattttt tggtgagata
      661 atgtataata aaaatgtatt ttactaattt tttatatgta aggagaatta ttgtgagaag
      721 aagacgaaaa aaaggtgcag atgaaaagct tttaagttat acaaaatatg ttttaagaga
      781 cgatatagac aaattaaaag gcaagtggaa tttaaagttt agaaatgata atccaataca
      841 tgttgaattt gggactggaa aaggtaagtt tataacaact ttagctaagc agaaccctga
      901 cataaattat attgccatgg aacttaagga agaagttctt ttaaaggctg ttgaaaaagc
      961 agatgcttct aatttgaata atatactatt tttatgggga gatgtaagca atattttgga
     1021 ttactttgaa gctaaagaat tatcgagaat ttatataaat ttctgtgacc catggcctaa
     1081 aaatagatgg agtaaaagaa gactcactca ttctggattt ttagaaatgt acaatagggt
     1141 tttggaagat gatggcgaaa ttcactttaa aacagataat gaaaaattat tcgagtttag
     1201 tttaaatgaa attgctgcaa ataattggct attaaagaat atttctcttg atttaggaaa
     1261 tagtgagtat gaaaataatg ttacaacaga gtatgaagac aaatttatgt cacaaggtat
     1321 gcgaatattt agatgtgaag ctaaaaaacg taactagtaa tatgtttata agtttaatag
     1381 tagaaattta ttttaattta tattaataaa gtgtacgaaa gtaggtatat ataacaagga
     1441 aacagaaccc tctcatagaa attaaattat tataataaaa aatttatgtg ggagggtact
     1501 atgaatttag ctaatttaat accatttatt atttctgcag cagctttaag tccaataaat
     1561 tcaaatgata aggttttgag cgaaaatcaa cttaaagata tttttcctga tgcaaattta
     1621 agagcagttg taaaaagata tataaatcca gatgagatga ctataagcaa tataaaggct
     1681 ttagatggag aattttatgc aactggtgag agcatttcaa atttaaaagg tatatcatat
     1741 cttgaaaatg tagacaattt tattttttgg aataataata taaaagagat tcctaaggaa
     1801 gctttaagtc taaaagatat ggattcaata aatcttgcca ataattattt gattgatgac
     1861 gatgtagtaa attctctttc tcataatggt gtggatgtaa attgcgattt aaattttatt
     1921 gatacaaaag ataatcagta taaactggac tctaaatatc ataacgttga tatagcaaaa
     1981 ggtgaaagta ttgatttgag aaaaataatt acgaagaaaa ttgatagtta ttataaatac
     2041 tgggaagtta ctgataacct tccaaaagat ttaaatttta ttgtatctgt aagtgataag
     2101 agtgtacttt catgtgaaga tatgataatt aaaggtaata aaacaggtca agcagtggta
     2161 aaagttatac taagcgacaa aaatgattta aatacatctc aagaagttct aattactgtc
     2221 aatgtaaaat aatctgtcaa cttattcaat cattctattt tcaatttaag tgtataatca
     2281 aaataaaggt tgttagtaac agaacgctaa tattagtgct ttgttactag caacctttaa
     2341 attttataga aatagattat ctaaaaaatt ccatttcttc tgttagtagc ccatattcct
     2401 attaaaatta tcagtgaata tattatatac aaaactattc ttatatattg gacatctaat
     2461 ccaaaaaatt caatgttact ctgtgaggta tgcaacatca caaggactgc agatatacca
     2521 ataagcaaag gattgattac tatttgctta tcagttctta aaatcattat tttacccatc
     2581 caaattattg ataatataaa aaataaaatt ttaagaccaa attctaatgt atctaccaaa
     2641 gcgaaaacat cccttcattt ataataaatt tttcagctca acaaaatata aaaccctaca
     2701 aacaactttt gaatccataa taagataact tgattaagca ctatgaaata agtactataa
     2761 aacttcatct acattaatat atactacact atacttcaaa tttcttaaac ataaattaat
     2821 gaaattaaca aaattttatt cagaaacata taaagatata ttttactatt taaatgcata
     2881 tcattatata tacagtttta ggaggtgagg tatatggaat ctaaattttt taattggtac
     2941 actcaatcct tagggggaac ttttggcatt atatcatgta tatgcgcata tttaaatgga
     3001 tacatgtttg tttatacaaa tagtgctagc aaatattttg aaagtatagg atttctggga
     3061 ataatttcaa gttatacact acttccactt tgtatgctta ctttgatttt tggagttata
     3121 tattcttata ctccagaaac atccgacaaa agtattttta atataccttt ttttacttta
     3181 aataaaagat taatacttat tacagtagtt tttggtttta taggtgctag agtttacttt
     3241 ataattcctg caattctaat aacttttaac ctatatagca atgttttgat agctaaatta
     3301 aagtacatcc tatgtaaaaa taaagaaaat gatactaatt tgaaagaaag cgaagtctaa
     3361 attgcataat attggtattt gtcttaaaaa ttcccgaggt attaatttgt attctcttgt
     3421 attttgcaaa aaatattgaa ttttattcat tttatactta taatttatat taataatgga
     3481 aaattaaaac aaatataagt tactggttgt taatttaaaa ttaaaagata tattgatgtg
     3541 ttgattctct agtcagcact ttttctttta taaatttgtt ttttgtgata taatattagc
     3601 accaggtaat aatacaaggg ggtaacaaaa tgaacatcaa tgaaattaag gaattattaa
     3661 aggccataga ctcaactaac ttagaatatg taaaacttga aagtagcgat ttaagattag
     3721 aagtatctaa aaaagctcaa tctacaagtt cacctgtttt aagtgtacaa caagaatcag
     3781 tagtggatct ttctttagaa aagccagttg taaacgatac acctgtcaca tctaatgaga
     3841 atctatcagt agtagtagct cctttgatgg gaacattcta tgattctcca agtccagatg
     3901 cagatagctt tgttaaagtt ggcgatgtag ttgaagaagg cgacacttta tgtatattag
     3961 aagcaatgaa gcttatgaat gagataacaa gtgaaattaa aggtgaaata attgaagtat
     4021 tagttagtaa tgaagaacta gtagaatata atcaaccttt atttaagata aaaccattgt
     4081 agtaggaggt atttaagttg ataaaaaaaa tactagttgc aaatagaggc gatatagcag
     4141 ttagaatcat cagaacatgt aaagaactag gtataaaaac tgttgctatc tattctgaaa
     4201 tagataaaga ttgttttcat agatatatag ctgatgaatc tatttgtata ggaccaaata
     4261 atataagtaa gagttataat aatatagaaa atataatcta tcttgctctt aaattaaagt
     4321 gtgatgctat tcatccaggc tttggatttt tatcagagaa tcctgaattt gcaaagcaat
     4381 gtgaagataa taatattatt tttataggtc caacaagaga acaaatgatt ttgatgggag
     4441 ataaatctag agcaagagaa actatgatgg aattgaatat ccctgttgtt cctggttcag
     4501 aatctgtttt gaaaactaag gaagaagctt tagaagttgc aagagaaatt ggatatcctg
     4561 ttatgataaa agcctcaagt ggaggcggtg gaaaaggtat gagaatcgtt agaaaagaag
     4621 aagaactttt ttcaaatttt gatatggcaa gttcagaagc tctagcagca ttttctaata
     4681 gtgatttata tatggaaaag tttatagaaa atcctagaca tatagaagta caagtatttg
     4741 gagataaaca ttcaaatgca atacatttag gtgatagaga ttgttctatg caaaggcgaa
     4801 atcaaaaagt aatagaagaa tctttaagtc catacctttc agatgaagaa agacaaaaac
     4861 ttcataaaat tgcagtagat atagtaaaag gagtaggtta tatcggtgca ggtactattg
     4921 agtttatagt tgacaaagat aaaaactttt attttataga gatgaataca agaatacaag
     4981 ttgaacatcc agttacagag atggtaacaa atcttgacct tataaaactt caaatatcta
     5041 tagctaatgg ggataaaatt ccttttaaac aagaagatat tacttttaga ggtcatgcta
     5101 ttgaatgtag aataaatgca gaagattcat caaagaattt tgctccatca ccaggtaaga
     5161 tagaatcatt aaatttacct ggaggttttg gtgttagatt tgatactttt gtatatgcag
     5221 gatatactat accaccttta tatgattcta tgataggtaa gttaatatgt tgggctgaaa
     5281 ctagagaaga atgtataagt agaatatata gagctctaga cgaaattatt gtagaaggta
     5341 ttaatacaaa tgtagaattt caaaaggcac ttgtaacaag tgaggagttt agagaagata
     5401 ctcatcatac caaatttata gaagatgtct ttatgaagaa agaatttgct acattataag
     5461 gagtaaatag attatgataa aaaaattttt atcatcaaaa gaatctaagt atgttacgat
     5521 ttctttagat gacaacttta aaaagaatag tgtagatgat aaattttgga cctattgcaa
     5581 aggttgtgat agtcatgtat ttagaaagga catagaagaa aattcatttg tatgtccaaa
     5641 atgttcaaga cattatggct taagagcaag aaaaagaata aatttattga ttgataaagg
     5701 aacttttatg gagtttaatt ctgatgtaga atttcaaaat ccactaaatt ttcctaaata
     5761 caaagaaaaa gtagactctt ataaggaaaa aacaaaagag tcagaagctg ttgtcacagg
     5821 ttatggaaga ataaatggaa ttaaaacagt tatttgtgta atgaatcctg attttatgat
     5881 gggaagtatg ggttctattg ttggggaaaa aataacttat tcaatagagt atgctgctga
     5941 aaataattta cctataatta tttgttctgc ttcaggagga gctagaatgc aagaaggtat
     6001 ggtatctctt atgcagatgg caaagacttc tcaagcactt tctaagcttg aagaaaaatt
     6061 attgccatat atatcagttc taactgaccc tactactgga ggagtaactg ctagttttgc
     6121 tatgcttggt gatattataa tttctgagcc aaatacgttg ataggttttg caggtccaag
     6181 agtaatagag caaacaataa atcaaaaact tcctgaagga tttcaaactt ctgagttttt
     6241 acttgaaaaa ggttttattg acatgatagt agatagaaga aaaatgaagg aagtattata
     6301 tcaaattctt gctatgcaca agaaataggg cataaaggag gaactgtttt gattgaaaat
     6361 aatagtgaaa aaataaaagt cttagaaaat gatattaaac aattaataac tatttctaag
     6421 gcaaataata tagatttaag tgataaaata aattcactta atgagaaatt ggaaaagctt
     6481 aaggaagatg ctttttcaca tctatcagca tatgaaaagg taacattaag tagagatata
     6541 aagagaccta cgacattgga atacatagaa catatttgtt ctaatttttt agaacttcat
     6601 ggagataggc tttttaaaga tgacccttct atggttggag gaattggtca gataggaaag
     6661 tttaatgtta ctatagttgg acaccaaaaa ggaagagata caaaagaaaa tataaaaaga
     6721 aattttggaa tgcctcatcc agaaggatac agaaaagcat taagacttat gaaacaagct
     6781 gaaaaattta atagacctat aataacgttt attgatacat caggagcttt ttgtggtcta
     6841 gaagcagaag aaagaggaca aggagaagct attgcaagaa acttacttga aatgagtaaa
     6901 ctttctgttc cagtaatcac ttttgtaatt ggtgaaggtg gtagtggagg agctttaggt
     6961 atcggagtag gaaatgatgt atgtatgtta gaacattcag tttattctgt aatttctcca
     7021 gaaggacttt ctagtattct atttaaagat tcatctaaag ctaaagaagc ttgtgatgtt
     7081 atgaagctta caagtaatga tttatatgat ttaaaaataa tagataagat tataaaagaa
     7141 cctcttggag gagcacaaaa agatgtagaa gctgtttcaa aagaaataaa agcttatatt
     7201 ttagaaagat taaatcatta caaagatatg gataaagagg aaattatagc tcaaagatat
     7261 aaaaaattta gaaatattgg aaaatgctta tagaatataa agaaatttgt agttttttca
     7321 taataaaatg gttaaaaaaa ataaaggttt tcttaaaacg attatagaag tatattttta
     7381 taaaagtata ctttaaatga tgattgtaat tagtaaatgg caattatgat ttagtacttt
     7441 aggtaatgga tactttaaca aattaacaag gagatgttga aatggaggta ctaaaagttt
     7501 catcaaaatc taatcctaat tctgtagctg gagccttggc tggagtacta agagaacgag
     7561 gcgttgcaga aatacaagct ataggagctg gagctctaaa tcaagcgata aaatcaattg
     7621 caatagcaag aggttttgtt gcacctagtg gaatggattt agtttgcatt cccgcattta
     7681 ctgatataga aatcgaaggt gataagaaaa cagccattaa acttataatt gaacctagat
     7741 aatatatctc tttattagaa tttaattaag ttttaaaggt tggctataga aataggacac
     7801 tatagtgaac cttttttact ttatatgttt tattttatgt aacttttaat gtataatctt
     7861 aagtaaacaa ataagattgg aggaaatata cattatgaaa ttaaaattat tggtagaaga
     7921 gtatgcagta tgtagattaa ataatgacag taaaatacca acatggatag atacagagaa
     7981 gttttactct ataactagaa ctgatgatga attaagtgtt gtatgtttaa ataataatat
     8041 tccttctgat gtcaagtcag aaaaggagtg gagaatactt aagatactag gtcctttaga
     8101 cttttcactt gtaggaattt tatctaagtt aagtagtttg ttagcagaca acaaaataag
     8161 catatttgca atttctactt atgatacaga ctatatctta gtaaaagaaa aagatataga
     8221 aaatgcttgt aaaattttaa gctgtaatgg atatgaagta gagtagttaa atacttttac
     8281 atgaggactt aacttatgat ttatataatc gaaattttaa aaataagtgt aataaatatt
     8341 ttttgtttca taggaatatt tattgtattt ggattgattt ttagcattac agaaaatcta
     8401 aataataaat ttatattttc atcttttgga aaaactggaa ttattgtaac tggagctata
     8461 ggaacgtttg ttcatgaatt gagtcatttg ataatgtgtt taattttcat gcataaaata
     8521 aattcagtta agtttttcag accaatagaa agtaaaaatg atggtatact aggatatgta
     8581 agtcatagct ataaaaaaga taatctttat caaagtatag gaaatttctt tataggaatt
     8641 gcacctatta taggtggaac aataatgatt attttaattt ttaagatatt actgccagat
     8701 agttatatga aagtgactca aaatatagat ttaaagttat atgtaagtat gattaataat
     8761 ttaaatataa atgggtttat acacattatt ttaggtgata tttccaattt tataagaata
     8821 atgttgttaa cacctagtgt atattcattg aagtatttta tatttatgtt tttaatgtat
     8881 tctatatcta cacatatgtc acttagtagt gctgatttaa aaaatagctt aaatggtctg
     8941 agctttatag ttatagttat ttttgtaata agttcaatta catacttatt tggatttgat
     9001 aacttgaata tatccagttt aatagttaag tataacatat ttataagttt ctttatggca
     9061 atagggttta ttttttcaat agtaactct
//
LOCUS       DAEPID010000119         9060 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.120, whole genome shotgun sequence.
ACCESSION   DAEPID010000119 DAEPID010000000
VERSION     DAEPID010000119.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 9060)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 9060)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..9060
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.120"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            197..586
                     /locus_tag="KR257_003497"
     CDS             197..586
                     /locus_tag="KR257_003497"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009901721.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="BlaI/MecI/CopY family transcriptional regulator"
                     /protein_id="HBH0032157.1"
                     /translation="MKQQEVVNKLRRGELMLMEYLWRKNSILSKKEIIEAMKEKYKWR
                     KSTTEILLKRLVKMKTLKKKRIGFQFSYEVLVTKKEYLNAIKEDRKVTKYDSFFIRMF
                     TTMHKKEKMTEEQIKKYIENMEKIGKE"
     gene            680..1063
                     /locus_tag="KR257_003498"
     CDS             680..1063
                     /locus_tag="KR257_003498"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009901722.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="BlaI/MecI/CopY family transcriptional regulator"
                     /protein_id="HBH0032158.1"
                     /translation="MGFKKLPDSELKVMKFIWGLDGNKVASGEVVEAMKQIYDWNKNT
                     TLTILSKLAKKNYLYSQKTSKCTYYTIAVREKDYLKVETKKFFSFFHNNSLKSFFTAL
                     NDEENLSDDKLDMLEEWVKNWEEDE"
     gene            1742..3172
                     /locus_tag="KR257_003499"
     CDS             1742..3172
                     /locus_tag="KR257_003499"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892580.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="metallophosphoesterase"
                     /protein_id="HBH0032159.1"
                     /translation="MILNQIFIEAGGIMRNKIIIGITFSLVLLMSGCASKQTAEINVL
                     ATTDLHGVIPYELTSYVKEERKKDKNLTLVDAGDFFDSGEVFGSSMDSYFSARYKDGD
                     NNTESYIETPISKDMKEVGYDVAVLGNHEFISNNKFYLDNMISDFEKQKINILSANTY
                     KKNGDSYTKPYIIKNINTPEGNVKLGILGLTIKEVGERKQWKDGKLVDSKSLELKDQE
                     GYNGELYMNDLVEDAKKWVGIMEKEKPDIIVAVAHTGEKPKKPKNPGNRIQDLAQQVD
                     GIDAIVAGHNHVQIEQHDYKNKSGENVIVTEPGKHGECISKINFKLEKNNDKWNIVDK
                     SSKLIKFEKNQESDKFGEFISSINKVSKDKKEIRLSEVKTPEWDKIYVFKSGTSADDI
                     YKTIGYKWRNISSPKGDDMVQIVVMNNNKPVSYVYGEAEVMPINIKCDESEYKDNVVT
                     IYPNKNDKFKIEKGKQEYSINLKHIQ"
     gene            complement(3320..3670)
                     /locus_tag="KR257_003500"
                     /pseudo
     CDS             complement(3320..3670)
                     /locus_tag="KR257_003500"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009904812.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="LysR family transcriptional regulator"
     gene            3665..4186
                     /locus_tag="KR257_003501"
     CDS             3665..4186
                     /locus_tag="KR257_003501"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860666.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="chromate transporter"
                     /protein_id="HBH0032160.1"
                     /translation="MFSIGGGYAIILLIQEKVVNQTGWISEKMFTDIITISQMTPGPL
                     AVNTSTFVGLQIGGFWGAVAATLGCVLCGVVISLFLYNFFQKHQNSTYIFEILNGLKS
                     ASLGLIISAAATIIILALFGTNKVYFNSIFEMLNWTALIIFFVTLLIVRKWKINPIVI
                     IIISGILGIFFYL"
     gene            complement(4315..5109)
                     /locus_tag="KR257_003502"
     CDS             complement(4315..5109)
                     /locus_tag="KR257_003502"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425320.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha/beta hydrolase"
                     /protein_id="HBH0032161.1"
                     /translation="MIFCNSFITRKSSMNIVVTHTPIVTTLEMQKAYEPLAKHNVNIF
                     AFDFSGTGKSDGYEKDFSRNSIVKDLDSVITYIEKNYSSNIHLYGNTGIGGMFAQYYA
                     CSDNKLKSFAQFACVDYKNTTGVGYTYLTVKLLNFFFKFLPNFHITVKPPKYKGYNEV
                     YDNEFYKIFEKKNPHIWKNSTKIINTMLECFIAKDSKIKDGVNIPTLVFKTLHDRYFK
                     TQYFDSYYNSLKCKKKLVEINNVHNSYYIDSEKFCQEAYDWFVENQ"
     gene            complement(5333..8761)
                     /gene="uvrA"
                     /locus_tag="KR257_003503"
     CDS             complement(5333..8761)
                     /gene="uvrA"
                     /locus_tag="KR257_003503"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729233.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="excinuclease ABC subunit UvrA"
                     /protein_id="HBH0032162.1"
                     /translation="MKINNYKNQSIITNPKKFENKYQDLPKTPIELLKVVQSLVIHGD
                     QGKLYGISFNKQQSDEELLRTIPQMLKRIFEINSNPLTIPRNPKQRLVGMCRDYSLLL
                     VSLLRYRGFEARMRAGFANYFESELTYEDHWLVEYYDTLTKRWIRIDAQIDDIQKNYF
                     QINFDTHDVGKTDGFLTGSEAWIRCRQGHAHQDDFGYNKNWKGWHSVKGNLLHDFNNM
                     IGLELLPWDLWTELSSKKYNQLTRAEKNLLDEMAEILSSGNIKIEDLNLLIEKLPEDY
                     LKSIFSQLKILGISEIKELGNPLELEKKFKFTKSINKSIKNSLCHNKSSIYLKGGRQN
                     NLKDVEVTIPKNQITVITGVSGSGKSSLAFDTIYEEGKRRYFENLSNGAKLSEQLQKP
                     EFDLLQGLTPTIAIEQKKGSQNPRSTVGTLTSIWDYLRMLFVSIGKSYCPYCKIPLEK
                     KNNTKNYCPHCQTIFSKINTSTFNANSHTGACHDCNGLGFTYQVNPQLIVKDPTISIL
                     DGATYYFGKLKGKKPNGNWMVGELYAIAKDKNIDLDIPWNELPRDFIDAILYGTDDKI
                     YEFSFESKGRESKIRRPASGAINHIQRLFRESSSENNTLHQYMNKIPCNTCGGELLCI
                     EARFTTIKGYRFPELTKMTIEQLWNWLCELPNQLQKNELSLVNDILTELKIRVSYLLK
                     VGLSYISTDRTAPTLSGGELQRVRLSSQLGSELVGLTYILDEPSIGLHPRDHNLIIKM
                     IEELRDKGNTVIVVEHDKDTILSADYIIDVGPSAGTKGGFIIAEGTTQEIIKNPNSIT
                     GKYLSTYNKISSQNKIIPSKWLSLKGCHANNLKNIDVEIPLNCMCSITGVSGSGKSSL
                     VFHSLLPALEEKLKQKSIPDKNYTEFTGFDAIDDFILMDQTPIGKSSRSTPATYINIF
                     DEIRSLFAETPQAKQKLLDESYFSFNSKKGQCPNCQGLGKTKIILQYMADQWVTCSEC
                     QGKRYQKEILSIQYKGKTIADILDMEVAEAKTFFSDCSDIYRKLSLLDEVGLGYLKLG
                     QNTLGLSGGESQRIKLAKELGTKTKKRMLYILDEPTTGLHFKDIENLLITFRKLVNEQ
                     HSLLIIEHNTEVIRASDWIIDIGPDSGINGGEIVASGTPDEIKINPNSITGHFI"
BASE COUNT         3231 a         1172 c         1368 g         3289 t
ORIGIN      
        1 aaaataatac aatagaatta gttattattc aacaaaattg tttgaaaatt taataatttt
       61 atagatatga aagttatttt cttctaagaa aacagactaa atgcgtagaa tatttggtaa
      121 aacttacctg tataaattga aatcagaagg ttttattatt gatttagatt agaacaattt
      181 gagggagtga cataaaatga aacaacaaga agtagttaat aaactacgca ggggagaatt
      241 gatgttgatg gaatacttgt ggaggaaaaa ttctatttta tctaaaaaag aaataataga
      301 agcaatgaaa gaaaaatata agtggaggaa aagtactaca gaaattctat taaaaagatt
      361 agtaaaaatg aaaacattaa aaaagaagag gataggtttt cagtttagtt atgaagtgct
      421 agtaactaaa aaagaatatt taaatgcaat aaaagaagat agaaaggtaa ctaaatatga
      481 tagttttttt atacgaatgt ttaccactat gcataaaaaa gaaaagatga cagaagaaca
      541 aataaaaaaa tatatagaaa atatggaaaa aattggaaaa gaataattta tatatatatt
      601 aattattttt aaaataaatt tgttataata tttaaatata cataaacata cataaattta
      661 caaaaagggg gtgtagctta tgggattcaa gaaattgcca gattctgagt taaaagtaat
      721 gaagtttatt tggggattag atggaaataa ggtagcatca ggagaagttg tggaagcaat
      781 gaaacaaatt tatgactgga ataaaaatac gacattaaca atattgtcta agcttgcaaa
      841 gaaaaactat ttgtattctc aaaaaacaag caagtgtaca tattatacta tcgctgtaag
      901 agaaaaagat tatttaaaag ttgaaacaaa aaaattcttt agtttttttc ataataattc
      961 tttaaaaagt tttttcactg ctttaaatga tgaagaaaat ttaagtgatg ataaattaga
     1021 tatgttagag gaatgggtga aaaattggga agaagatgaa taaaatgaat gtgatactaa
     1081 aatgatacta atatgtttta tagcgtgtta aaaaatatag aaaatataga aataatagaa
     1141 gaaaattaat gtaatagata aggttttatc agattaaaaa gaaaatcaat agaatgggaa
     1201 taaaatatag aatgccaaaa atccacataa atacaggatt tgaggtctct cttacttcta
     1261 tgttatactg gtttgatact atcaatattt gccagtatct tatggattaa taagcaaaaa
     1321 acatcctgct gaatgataaa ttcagcgggg tgtttttatt ttgttttaga actcctttgc
     1381 tctgaaactc gaagtattta acactgatga ttttgttatc ttttagttcc ttttgtgtca
     1441 tgctctgaaa gacaaattga tacaataaaa aagtaatttc ttaatcattg atggagatat
     1501 gtgtttatgt tactcttgat ggtaatttga gtaatattgt tcatagcttt ttatattcac
     1561 ttaattagaa aaccatttgg tataatcata aataaacttg atgatataat agaaaagatt
     1621 tataattatt agaagtatat aaaagtattt tatgtctatg aaatgtatgt ctataaaaca
     1681 tatagatgac ttttgtatat taatgtatga atattgatat tatagaagaa ttgagttgtc
     1741 aatgatacta aatcaaatat ttatagaagc tggagggatt atgagaaata aaataattat
     1801 aggaattact ttttcacttg tattactaat gtctggatgt gcttcaaaac aaaccgcaga
     1861 aataaacgta ttagcaacta ctgatttaca tggagttata ccttatgagt taacttctta
     1921 tgtaaaagaa gaaagaaaaa aagataaaaa tctaacttta gtagatgcag gagatttttt
     1981 tgatagtgga gaagtgtttg gttctagcat ggatagttat tttagtgcta gatataaaga
     2041 tggtgataat aacactgaaa gttatattga gacgcctatt tcaaaagata tgaaagaggt
     2101 aggttatgat gttgcagttc ttgggaatca tgaatttata tccaacaata aattttatct
     2161 agataatatg atatctgatt ttgagaagca aaaaataaat attttatcgg caaatacgta
     2221 taaaaaaaat ggagatagtt atacaaaacc atacataata aaaaatatta atacacctga
     2281 aggaaacgta aaactaggaa ttttagggct tactataaaa gaagttggtg agaggaaaca
     2341 gtggaaagat ggaaaacttg ttgactctaa gtctttagaa ctaaaagacc aagagggtta
     2401 caatggtgaa ttgtatatga atgatttagt agaagatgct aaaaagtggg ttggtataat
     2461 ggaaaaagag aagcctgaca ttatagttgc tgtggcacat acaggtgaga aacctaagaa
     2521 acctaaaaac ccaggaaata gaatacaaga cttagctcaa caagttgatg gaattgatgc
     2581 tatagttgca ggtcataatc atgttcaaat tgagcaacat gattataaaa ataaatcagg
     2641 agaaaatgtt atagttactg agccaggaaa gcatggggaa tgtatttcta agattaattt
     2701 taaattagaa aaaaacaatg ataaatggaa tatagttgac aaatctagta aattaattaa
     2761 atttgaaaaa aatcaagaaa gtgataaatt tggagaattt atttcttcaa ttaataaagt
     2821 aagtaaagat aagaaagaaa taagattatc agaagtaaag actcctgaat gggataaaat
     2881 atatgttttt aaatctggaa catctgcaga tgatatatat aaaacaatag gatataaatg
     2941 gagaaatata tcatctccaa agggtgatga catggtgcag attgttgtaa tgaataataa
     3001 taagcctgtt agctatgtat atggtgaagc tgaagttatg ccaattaata taaaatgtga
     3061 tgaatcagag tataaagata atgttgtaac tatttatcct aataaaaatg ataaatttaa
     3121 aattgaaaaa ggtaaacaag aatatagtat taatttaaaa catatacaat agaaactttt
     3181 atcttattta agtttagatt gtacttaaaa taaagtgtgt attattttaa aaattgatga
     3241 taattaaaat cacaacatta aagaatagta cacacttttt atgctaaaaa atagaatgtt
     3301 aaaaaattaa acctttaaat taaagtacat tgcttatatt atccaatatt attttcaaag
     3361 gttgtgtaat atttttatcc ttatgtaata ttgctaacat tttattttcc atatctatcc
     3421 catctaattc aatcaatcgc aattttttat gtaagagtga atctaataat aaattttctg
     3481 gcaaaatggt tatacctaac cctgcttgtg cagctttaat aagtgcaaaa gaattaacac
     3541 tttcccaaac aggataagct ttttggtttg aaagagataa tacactgtcc aaagtattgc
     3601 gaatggcact tccttgctca cgtaacaata acggaaacgt gcataactgt cgtagagata
     3661 aggcttgttt agtattggtg gtggttatgc aatcatactt ttaatccaag agaaagtagt
     3721 aaatcaaact ggatggataa gtgagaaaat gtttacagat attataacta tttcacaaat
     3781 gacaccaggg ccactggctg ttaatacttc tacttttgtt ggacttcaaa ttggagggtt
     3841 ttggggagca gttgcagcca ctttaggttg tgtattatgt ggtgtagtaa tatctctatt
     3901 tttatataat ttttttcaaa agcatcagaa ctctacttat atatttgaaa tattaaatgg
     3961 tctaaaatca gcttcattag gtttaattat ctcagctgcg gctacaatta taatccttgc
     4021 attatttggg acgaataaag tgtacttcaa ttctatattt gagatgctaa actggactgc
     4081 actaataatc ttttttgtta cactactgat agtacgtaag tggaaaatta atcctattgt
     4141 gattataata ataagtggta tactgggaat atttttttat ttataagttt ttggtaagta
     4201 gaggatatct atttttttat atcttaaatc caaatagcca ataaagtaag gccatttgga
     4261 tttttaataa attctgaaaa gataatcaga aacccatata acatttaaat tatatcactg
     4321 gttttctaca aaccaatcat aagcttcttg gcaaaatttc tcactatcta tatagtaact
     4381 attatgaaca ttattaattt caacaagttt ctttttacat tttagtgaat tataatagct
     4441 atcaaaatat tgggttttaa aatatctatc atgaagtgtt ttaaagacaa gagtaggtat
     4501 gttgactcca tcttttatct tactatcttt tgcaataaag cattctaaca ttgtattaat
     4561 tatctttgta ctatttttcc aaatatgagg atttttcttt tcaaatattt tataaaattc
     4621 attatcatag acttcattat aacctttata tttaggtggt tttactgtta tgtgaaaatt
     4681 aggaagaaac ttaaagaaaa agtttaataa tttaacagtg agataggtat agcctactcc
     4741 tgttgtgttt ttataatcaa cacaagcaaa ctgagcaaaa ctttttaact tattgtctga
     4801 acatgcataa tattgtgcaa acataccacc aattcccgta ttcccatata gatgtatgtt
     4861 ggaagaataa tttttttcta tgtatgtaat gacagaatct aagtctttta caattgaatt
     4921 gcgagaaaaa tctttttcat atccatcact tttccctgtt cctgaaaaat caaaagcaaa
     4981 tatatttaca ttatgtttgg caagtggttc atatgctttt tgcatctcaa gcgtagtgac
     5041 aataggagta tgtgtaacaa caatattcat ggatgatttt ctggtaataa atgagttaca
     5101 aaaaatcatt gtatctccat ttggtatttt tatatgtttc caactcattt gattttcctt
     5161 tctctattat aaaatataat aatttttatg ttctgtttta tatattattc atattttatc
     5221 acagataata tactaaagtt aattttttta ttgtacacct attataataa ttcttctata
     5281 atataagaca ttctataatt ttatatttaa gttcatgtgt atttaattgt ttttatataa
     5341 aatgtccagt aatactattt ggatttattt ttatttcatc aggagttcca gaagcaacaa
     5401 tttcccctcc atttattcca ctgtctggac ctatatcgat aatccaatca gaagcacgta
     5461 taacctctgt attgtgttca ataattaaaa gtgaatgctg ttcatttaca agttttctaa
     5521 aagtaattaa caaattttct atatctttaa aatgaagtcc agtagtaggc tcatccaata
     5581 tgtacagcat tcgtttttta gtttttgtcc ctaattcttt tgctaatttt atcctttgag
     5641 attctcctcc acttaatcct aatgtatttt gtccaagctt tagatatcca agtcccactt
     5701 catctaataa ggagagtttt ctatatatat cagagcaatc gctaaaaaat gtttttgctt
     5761 ctgctacttc catgtcaagt atatctgcaa ttgtctttcc cttgtattgt atagacagta
     5821 tttctttttg atatctctta ccttgacatt cactacaagt tacccattgg tctgccatat
     5881 attgcagaat aatttttgtt ttacctaatc cttgacagtt tgggcattgc ccctttttgc
     5941 tattaaagct aaaatagctt tcatccaata atttttgttt tgcttgtgga gtttcagcaa
     6001 atagagaacg aatttcatca aaaatattga tatatgtagc aggtgtagaa cggctagatt
     6061 ttccaatagg tgtttggtcc attaagataa aatcatcaat agcatcaaat ccagtaaatt
     6121 cagtataatt tttatctggg atagattttt gtttcaattt ttcttctaga gcaggaagta
     6181 aactgtgaaa tacaagagag ctcttaccag aaccactaac acctgtaata gagcacatac
     6241 agtttaaggg aatttctaca tcaatatttt ttaagttatt tgcatggcat ccttttaagc
     6301 ttaaccattt acttggtata attttatttt gtgaacttat tttattgtat gtgcttaaat
     6361 atttacctgt tatagagttt ggatttttta taatttcttg ggttgtacct tctgcaataa
     6421 tgaacccccc ttttgtacca gcacttgggc ctacatcaat aatataatca gcagacagta
     6481 ttgtatcttt atcgtgttcc acaactataa cagtattacc cttatctctt agctcttcta
     6541 tcattttgat gattaaatta tggtctcttg ggtgtaaacc aatagatggt tcatctaaaa
     6601 tgtaggttaa gcctactaat tcacttccta gctgacttga taatcgtact ctctgcagtt
     6661 ctcctccaga taaagttgga gctgttctat ctgttgatat atagctaaga cctaccttta
     6721 atagataact aactcgaatt tttaattctg ttaagatatc atttaccaaa gagagctcat
     6781 ttttttgaag ttgatttggt aattcacaca accaattcca taactgttct atcgtcattt
     6841 ttgttagttc agggaagcga taacctttga ttgtagtgaa tctagcctca atgcacagca
     6901 attcgccacc acatgtattg caaggaattt tgttcatata ttgatgcaag gtattatttt
     6961 cagaactaga ttctctaaaa agtctttgaa tgtggttgat tgctcctgaa gcaggtcttc
     7021 taatctttga ttctcgtccc tttgattcaa agctaaattc atatatctta tcgtctgtac
     7081 catataagat tgcatctata aaatctcttg gtaattcatt ccaaggtata tctaggtcta
     7141 tatttttatc ttttgctatt gcatataatt cacctaccat ccaattacca tttggctttt
     7201 tccccttcaa ttttccaaaa tagtaagtag ctccatctaa tattgaaata gttgggtctt
     7261 ttacaatcaa ttgaggatta acttgatagg taaaacctaa tccattacaa tcgtgacaag
     7321 ctccagtatg ggagttagca ttgaaggttg aagtatttat cttagaaaaa atagtttgac
     7381 aatgtggaca ataatttttt gtattattct ttttttctaa tggaatttta caatatggac
     7441 agtaactttt tccgattgat acaaataaca ttcttaaata atcccaaatg cttgtaagag
     7501 taccaacagt agagcgagga ttttggcttc cttttttctg ttcgatagct atagtagggg
     7561 ttaatccctg aagtaaatca aattccggtt tttgaagctg ttctgaaagt tttgctccat
     7621 tacttagatt ttcaaaataa cgtctttttc cttcttcata aatcgtatcg aaagctaaag
     7681 aagattttcc actaccactt acacctgtaa taacagttat ttgatttttt ggaattgtaa
     7741 cctcaacatc ctttaaattg ttttgccttc ctccttttaa atagatagag cttttattat
     7801 gacaaagtga atttttaatt gatttattta ttgattttgt aaatttgaat ttcttttcga
     7861 gttcaagagg attgcctaat tcttttattt ccgaaatgcc taatattttt aactgagaaa
     7921 agattgattt caaataatct tcaggcaatt tttctattaa caaattaagg tcttctattt
     7981 ttatatttcc gcttgataat atttctgcca tttcatctaa taaatttttt tctgctcttg
     8041 ttaattgatt gtattttttg gaacttaatt ctgtccataa atcccatgga agcaattcta
     8101 aaccaatcat attattaaag tcatgtagaa gattaccctt tacagaatgc caacctttcc
     8161 aatttttatt atatccaaag tcatcttgat gagcatgtcc ttgccgacat cttatccagg
     8221 cttctgaacc agttaaaaaa ccatctgttt ttccgacatc atgagtgtca aaattaattt
     8281 gaaaataatt tttttgtatg tcatctattt gtgcatctat tcttatccat ctctttgtta
     8341 gagtatcata gtattctaca agccagtggt cttcataagt aagctcactt tcaaaataat
     8401 tagcaaaacc tgctctcatt ctagcctcaa aacctcgata tcttaggagc gatacaagaa
     8461 gtaaagaata atctctgcac attccaacaa gcctttgttt tgggtttctt ggaatagtta
     8521 gtgggttaga atttatttca aatattcttt ttaacatttg aggaattgta cgaagcaatt
     8581 cctcatcaga ttgttgttta ttaaaggata taccatataa ttttccttgg tctccatgaa
     8641 ttactaggct ttgaaccact tttaataact caattggagt ctttggtaaa tcttgatatt
     8701 tattttcaaa ttttttagga tttgtgatga tgctttgatt tttatagtta tttattttca
     8761 tttatatttc acctctctaa atggatgata taccctgaca tggtgtcata tgcaagggca
     8821 atttaaattt tttggccaaa atttaaaaat aaataaaaaa tgatacagtg ataaattgta
     8881 atacaaatat agtttcaaat tgcatataat ataattattt aataaaacca ttatctatgg
     8941 aatgttaatg aaatgttaag atggcattct tgaatattaa gaaatagaat actataatat
     9001 agtgtgaagg atttttagta aaaaaatttg taagtgttaa tatacattaa aaaatagatt
//
LOCUS       DAEPID010000120         8559 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.121, whole genome shotgun sequence.
ACCESSION   DAEPID010000120 DAEPID010000000
VERSION     DAEPID010000120.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 8559)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8559)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..8559
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.121"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            complement(220..711)
                     /locus_tag="KR257_003504"
     CDS             complement(220..711)
                     /locus_tag="KR257_003504"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729184.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YfbM family protein"
                     /protein_id="HBH0032163.1"
                     /translation="MGMIGCYTKISEENVFKLQQAEENLQDFVFEDANENSTINIDKA
                     WHAIHFTLTGCPFGGDDDNIFSKLVLSGNILMEIDGEFPVMLITANDVKKLSKAMNSL
                     EEQAFRKRFNINEMLENNIYPVMNDESEDDFFEYVWANLIELKKFIQEASNDGLAVIF
                     FIM"
     gene            complement(1931..4066)
                     /gene="rnr"
                     /locus_tag="KR257_003505"
     CDS             complement(1931..4066)
                     /gene="rnr"
                     /locus_tag="KR257_003505"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429582.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribonuclease R"
                     /protein_id="HBH0032164.1"
                     /translation="MIPGLKESLLGLINESAYNPLKKEELAEIFDIHSSEMPMFYNFL
                     NELEEDGYICFTKKGKIVSPNQMGYFVGKFVSHKKGFGFVESDVEYTQDLFISSDNIN
                     GAMHNDRVMAEIVVPATEEKRAEGRIVKVIKREITRIVGTFQSSKTFGFVTPDNKKFT
                     KDIYIPKKHFSGAVDNDKVVCEITVWPQEDRKPEGKIIEILGQKGERGVEIDSIIREH
                     GLPEEFPKKVLQEAEAVAVEIPQEEIKRRRDLRDLNIFTIDGDDAKDLDDAISIEVLP
                     NGNFKLGVHIADVTHYVREKNKLDKEALKRATSVYLVDKVIPMLPKTLSNGVCSLNPF
                     EDKLTLSIFMEIDHKGNVVKHEICESVINSKARMTYTEVSDILEKDDEKLKKTFEHVV
                     EDFKNAEILARILMSRREKRGAIDFNFPEAKIILNGKGEVVDIKPYERRISNKIIEEF
                     MLISNETIAEHFYWMGIPFVYRIHETPSLEKMEELSKFISTFGYIIKGDKEEVHPKAL
                     QGIIEKIKGKKEEGAISTIMLRSLKQAKYSPECSGHFGLAAKFYCHFTSPIRRYPDLQ
                     IHRIIKESLNNKISGKRQEQLTTIVDYASVQSSEKERKAELAERDVHDFYKALYMKDK
                     VGQEFEGVVSSVTSFGIFVELDNTIEGLIRLANMNDDYYIYDESSYSVLGERTKKSYK
                     IGDLVKIKVESVNVDFKEIDFEIVEKIEE"
     gene            4659..5273
                     /locus_tag="KR257_003506"
     CDS             4659..5273
                     /locus_tag="KR257_003506"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729185.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA alkylation repair protein"
                     /protein_id="HBH0032165.1"
                     /translation="MEEVIAKIITIENGFKEIENIAKKIVKNNDSKKCYYLSIYLYRS
                     EYYQVRELAVFILGFISVTISEALLFLKDNVSKDENWRVQEILAKSFDYYCSEVGYEK
                     ALPVIKEWLNSDSPNIKRAVTEGLRIWTNRDYFKSNPDVAISLLSSLKEDDSEYLRKS
                     VGNALRDISKKYPDLVKKELDSWDISNKKVEFVYKLASKCILAK"
     gene            5291..5653
                     /locus_tag="KR257_003507"
     CDS             5291..5653
                     /locus_tag="KR257_003507"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898297.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HBH0032166.1"
                     /translation="MKLRDEYTCPLELTHDMIKGKWKSIILWRLRIGPTSLSKLEKEI
                     NGINQKMLLEQLKELIEFGLVDKKTYEGYPLKVEYSLTPIRGKQILDALAIMQDIGIS
                     FMLDNGMEDILKEKGVLK"
     gene            5759..6256
                     /locus_tag="KR257_003508"
     CDS             5759..6256
                     /locus_tag="KR257_003508"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421940.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YbhB/YbcL family Raf kinase inhibitor-like
                     protein"
                     /protein_id="HBH0032167.1"
                     /translation="MKVTSTGIVNGVIEDKYGKRGTQFNEGGMPTYSLPLKFEDAPKN
                     TVSFAVFLEDKDSVPVCGFAWIHWLAVNITKDELNENESVTATDFVQGTTSWHGKLGG
                     LDRLEASVYGGMAPPDRPHVYEIHVFALDTILDLEKGFYMNEFFKAIEGHVLDTFTLK
                     GSYSN"
     gene            7060..8178
                     /locus_tag="KR257_003509"
     CDS             7060..8178
                     /locus_tag="KR257_003509"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861600.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
                     /protein_id="HBH0032168.1"
                     /translation="MIAVKKAYKFRIYPNKKQQELINKTFGCCRFVYNKYLAKRIDVY
                     KNDKETFTYKQCSSDLTNLKKELNWLKEPDKFSLQNALKDLDNAYKKFFKEKAGFPKF
                     KSKKINRFSYKTNFTNGNIMYCGQHIKLPKLGMVKVRDKQVPKGRILNATISKEPSGR
                     YYVSLCCTDVDIEAFENTNNHIGLDLGIKEFCISSCGEFIENPKYLKKSLNKLAKLQR
                     ELSRKTIGSLNRNKARLKVARLQEHIANQRNDFLQKLSTKLIKENDIICIEDLQVKNM
                     IKNHKLSRLISDVSWSEFIRQLEYKANWYGRQIVKVGKFFASSQICNKCGYKNEEVKD
                     LNIREWICPSCNETHDRDINASINILKEGLRLITIQNK"
BASE COUNT         3075 a         1198 c         1048 g         3238 t
ORIGIN      
        1 aaataaaaat atctgcaact atatattgca aaaatttaaa actaatttat atatgctaat
       61 ataaatattt ataaagacat aagacaaatt tacctacaga tttaaattta acttatatat
      121 tttaaaaggc taatataata tgtattttct tctatacaat caaaaggctt catatctaag
      181 atatgtgatg acactaatat tcacaatttt tagtaattat cacattataa aaaatattac
      241 agctagtcca tcattagatg cttcttgtat aaacttttta agctcaatta gatttgccca
      301 tacatattca aaaaaatcat cttcactctc atcattcata acaggataaa tattattttc
      361 taacatctca ttaatattaa atctttttct aaatgcttgt tcttccaaac tgttcattgc
      421 ttttgatagt ttttttacat catttgctgt aatcaacatg acaggaaatt ctccatcaat
      481 ttccataagt atgtttccac ttagtactaa tttgctaaat atattatcat catctccacc
      541 aaaaggacaa cctgtcaaag taaagtgaat ggcatgccat gctttatcaa tattgatagt
      601 actattttcg ttggcatctt caaaaacaaa atcttgtaaa ttttcttctg cttgctgtaa
      661 tttaaaaaca ttctcttcac ttattttagt ataacatcct atcattccca taattacatt
      721 cctcctaagt agcgtttttt taattgtaac ttataattaa acttagttac aataaaatat
      781 attgagaaaa gtattatttc atcttaaatt taaataccta tattatcaac taaaattctg
      841 tgtttatagc gtaagtatta ttttttccta aaaattaaat gaatcagagg ttctataggc
      901 aatattgact ataaataaga actattactt tttaaaaaaa atttaagaaa ttatactgta
      961 gaatcatgct ctacttatta gctttaaata aaaaataaat cattttctca aattaaataa
     1021 taaataacaa taaatttaaa ttttaaacta taagagtttc tgaagtgtta ataagcatac
     1081 caataattat atgtgtaaga atttgattta atagatatga ataattttta cattaattat
     1141 aaatatatta acctattgtt ataaattcta aaaaagaaaa gttatcttaa ataaaaaata
     1201 agtgtatctt aaattttaaa tgatacactt atttttatat tgaaattata ttttttaata
     1261 tctattctta attaggtatt tttaaattat ctgtttacat taaatatttc ttaattactt
     1321 atctttcagc tagctttttc tattaaatgt ttctcaatta cttatttttc aattagccac
     1381 ttctattaag catttcttaa ttacttattt ttcaattagt cacttctatt aaacatttct
     1441 taattattta tttttcaatt agccacttct attaagcatt tcttaattac ttatttttca
     1501 attagccact tctattaagc atttctcaat tacttatttt tcaattagcc acttctatta
     1561 agcatttctt aattacttat ttttcaatta gccacttcta ttaagcattt cttaattact
     1621 tatttttcaa ttagccactt ctattaaaca tttcttaatt atttattttt cagttggctt
     1681 tttctattaa atgtttctta attacttatc tttcagttag ctctttctat taaacatttc
     1741 tcaattactt atttttcaat tagctacttt cattaaatat ttcttaatta tttatctttc
     1801 agttaactat ttccattaga tatttctcaa ttacctattt ttatcattta ttttatagag
     1861 tattgtgcac tatatattta tacatatcat aaatactaca acttgttatc tcttatttta
     1921 gctgttttat ctactcctct attttttcaa ctatctcaaa gtcaatttct ttaaaatcta
     1981 cattaacact ttcaaccttt atcttaacaa ggtcacctat cttatatgac ttcttagttc
     2041 tttctcctaa aacactataa gaactctcat cataaatata gtaatcatca ttcatatttg
     2101 caagtcttat caacccttct atggtattat ctaactcaac aaatattcca aatgaagtta
     2161 cgctagatac aacaccctca aattcttgac caactttatc cttcatataa agagccttat
     2221 agaaatcatg tacatctctt tcagctaact ctgcctttct ttctttctcg gatgattgaa
     2281 cagatgcata atccactata gtagtaagct gttcttgtct ttttccactt attttattat
     2341 ttaaagattc ttttattatt ctatgaattt gaaggtcagg atatcttctt attggtgaag
     2401 taaagtgaca gtagaattta gctgctaatc caaaatgtcc actacattct ggtgagtact
     2461 tagcttgttt taaagaacga agcattatag tactgatagc tccttcttct tttttgccct
     2521 ttattttctc tattatacct tgtaatgctt ttggatgtac ttcctcttta tcacctttta
     2581 ttatatatcc aaatgtagat ataaacttac tcaattcttc cattttttcc aaagatggtg
     2641 tctcatgtat tctatacaca aacggtattc ccatccagta aaaatgttcg gcaattgtct
     2701 cattacttat aagcataaat tcttctatta tcttattaga tattcttctt tcatatggct
     2761 ttatatctac aacttcgcct tttccattta gaattatctt tgcctctggg aaattgaagt
     2821 ctatagctcc tcttttttcc cttcttgaca taagaatcct agctaaaatt tcagcatttt
     2881 taaaatcttc aacaacatgt tcaaaagtct ttttaagttt ttcatcatcc ttttctaata
     2941 tatcagatac ttctgtataa gtcattctag cttttgaatt tattacagat tcacatattt
     3001 catgtttaac cacatttcct ttatggtcta tttccataaa tatagaaaga gttagcttat
     3061 cttcaaatgg atttaagcta catactccat ttgaaagagt ttttggcaac attggaatta
     3121 ctttatctac taaataaact gatgtagctc tttttaaggc ttccttgtca agtttatttt
     3181 tctctcttac ataatgtgta acatcagcta tgtgaactcc tagtttgaag tttccattag
     3241 gtaatacttc tattgatatg gcatcatcta agtcttttgc gtcatctcca tctatagtaa
     3301 atatgtttaa atctcttaaa tctcttcttc tttttatctc ttcttgagga atctcaacag
     3361 ctacagcttc tgcttcttgc aatactttct ttggaaattc ttctggaaga ccatgttctc
     3421 ttattataga atctatttct acgcctcttt cacctttttg acctagtatc tctataattt
     3481 tgccttctgg ttttctatcc tcttgtggcc atactgtaat ttcacatact accttatcat
     3541 tatctactgc tccactaaaa tgttttttag gtatatatat atctttagta aatttcttgt
     3601 tgtctggtgt tacaaatcca aaagttttac ttgattggaa ggtacctact attctagtta
     3661 tttctctctt tattactttt actattcttc cttctgctct cttttcttca gttgcaggta
     3721 ctactatttc tgccataact ctatcattat gcatagcacc atttatattg tcacttgaga
     3781 taaataaatc ctgtgtatat tcaacatcag attctacaaa tccaaaaccc tttttgtgtg
     3841 atacaaattt tccaacaaag tatcccattt gattgggaga tactattttt ccttttttag
     3901 taaagcagat ataaccatct tcttctaatt catttaaaaa attataaaac attggcattt
     3961 ctgatgaatg tatatcaaat atttctgcta attcttcttt ttttagagga ttatatgcac
     4021 tttcatttat taatcctagc aaactttctt taagtcctgg tatcattttt ccctcctgtt
     4081 ttacttttca ttatattatt atttatattg tcttttatat ttcttcagac aaaacatttt
     4141 ttacttatca cataattttc tatattttct tattattata agttaaaatt acttatttat
     4201 atttttgatt taatgtaatc tttgtcatac taacttcaaa caaattatga tgttttataa
     4261 attatttgta aatatcatta taattactta agttattctt tatcataatt gcttaaatta
     4321 ctctttatca cctaattata caccatcaaa taggattggt aaaatattca tctcatataa
     4381 gtattactat ataataattt attctattag tatactcaaa tcatgtaaaa tttatataac
     4441 tcaattaatt ttttaaatac aactttataa tataaaactt ataataaaag taaatttata
     4501 tgttaaatga ggttgatttt ttattatttt ttatttatgc tagtactaaa gacttgcaaa
     4561 cgttttttga caagtcttta ttttgtctaa attaaacaaa cttttttaca aataaataca
     4621 taaaatttaa actaatctat ttattggagg agataaaatt ggaagaagta attgcaaaaa
     4681 ttattactat agaaaatgga ttcaaagaaa ttgaaaacat tgctaaaaaa attgtaaaaa
     4741 ataatgactc aaaaaagtgt tattatctat caatctactt atataggtca gaatattatc
     4801 aagtaagaga attggctgtg tttatacttg gttttatatc agtaactatt tctgaagctt
     4861 tgttattttt aaaagataat gtgagtaaag atgaaaactg gagagtacaa gaaatactag
     4921 ctaaatcatt tgattattat tgcagtgaag taggatatga aaaggcactt cctgttataa
     4981 aagaatggct taattctgat agtccaaaca taaaaagggc tgtgacagaa ggtcttcgaa
     5041 tttggactaa tagagactat tttaaatcta atcctgacgt tgctatatca ctactttcta
     5101 gtttaaaaga agatgatagc gaatacttga gaaagtctgt aggtaatgct cttagagata
     5161 taagtaaaaa atatccagat ttagtaaaaa aagaattaga ttcatgggat atatcaaata
     5221 aaaaagttga gtttgtatat aagcttgctt caaaatgtat cttggcaaag taaaatggag
     5281 gtgaacttat ttgaaacttc gtgatgagta tacttgccca ttagaactaa cacatgatat
     5341 gataaaaggc aaatggaaat ctattatatt atggagatta cgcataggac caacttcctt
     5401 atcaaaactt gaaaaggaaa tcaatggtat taatcaaaag atgttacttg aacaacttaa
     5461 agaattaatt gaatttggtc ttgtagataa aaagacatat gaaggttacc cacttaaagt
     5521 cgaatactca cttacaccta ttcgagggaa acaaatattg gatgctttgg ctataatgca
     5581 agatatagga attagcttta tgttggataa tggtatggaa gatattctta aggaaaaagg
     5641 tgttttaaaa taaatagata cccacaaaaa agtaagtaat ttaccattat tttcaactgg
     5701 tatataatta aattatagat atattctatt aatttattat aataggaggt aaattattat
     5761 gaaagtaact agtacaggta tagtaaatgg tgttatagaa gataaatatg gtaaaagagg
     5821 aactcagttc aatgaaggtg gtatgcctac atattcacta cctctaaagt ttgaagatgc
     5881 tccaaagaat acagtatcct ttgctgtatt tttagaagat aaagactctg ttcctgtatg
     5941 tgggtttgca tggatacatt ggttagctgt aaatataaca aaagatgagt taaatgaaaa
     6001 tgaaagtgta acagctactg attttgtaca agggactact agttggcatg gtaaactagg
     6061 aggtcttgac agattagagg ccagtgtata tggtggaatg gctcctccag acagacctca
     6121 tgtctatgaa atacatgtat ttgcacttga tactatcctt gaccttgaaa aaggattcta
     6181 tatgaatgaa tttttcaaag ctattgaagg gcatgtttta gatacattta cactaaaagg
     6241 aagttattct aattaattag gttgactata gctaatcatt aattaaatga tacatttaat
     6301 tgatgattag cttaattgtt attagaatat tttctgcact ttatcttaat atatatttta
     6361 gttgactggt attttaattt ctattagatt attatcaatt tatataaatt gattaaaaaa
     6421 tagctacgca cactcgtgac tttagtcatg agttagtagc taaaatagtc agcatatagg
     6481 gaaacttata tgtagagata ggatagaacc tatccaatac tacttgaatt gctaaaaacc
     6541 cctaaagcta accaaactaa aacataagga tgaaataaac ctaagtgtga aagttacgaa
     6601 agtagaaaaa attggttaga tggtataagg ttaaacccta agtactttaa aatgggcaat
     6661 cagcaggtaa actccaaata ggagaaactt caacgactat tcctcttgag ggaagtacac
     6721 tacaagttat cggtagtgga agtgggtaga ccttagcaga taatgccgaa ggataagata
     6781 tagtctgtgc ttatgtgaaa gtgtaagaag ttcataagag aactgcatag gtagtagcga
     6841 acttatgtga acgacaacct caaaaatgat aaaagttaag acttacggtt cttatatatg
     6901 ttatttaaaa ttaaatataa aaccttctaa ataattgttt taaataatta catttgttaa
     6961 cattattata ggtgattaat aaattgttca ccacagcatt atataatata ttaaatatta
     7021 aaatcattaa aaagtgtatc aaaaaacaat taaagtgagg tgatagcagt gaaaaaagct
     7081 tataagttta gaatatatcc taataaaaaa cagcaagagt taattaacaa aacttttgga
     7141 tgttgtaggt ttgtatataa taaatatctt gctaaaagaa tagatgttta taaaaacgat
     7201 aaagaaactt ttacttataa acagtgtagt tctgatttaa ccaatttaaa aaaagaatta
     7261 aattggctta aagaacctga taaattttca ctacaaaacg ccttaaaaga tttagataat
     7321 gcatataaaa aattctttaa agaaaaggca ggatttccta aatttaaatc aaagaaaatt
     7381 aatagatttt catataaaac taactttaca aatggaaaca ttatgtattg tggtcaacat
     7441 ataaaactac ctaaacttgg tatggttaag gtaagggata aacaagtacc taaagggaga
     7501 atacttaatg ctactatatc taaagaacca agtggtagat attatgtatc attatgctgt
     7561 actgatgtag atattgaagc atttgaaaat actaataatc atataggttt agatttagga
     7621 attaaagaat tttgtatctc aagttgtgga gaatttatag aaaatcctaa gtatcttaag
     7681 aagtcattaa acaaacttgc taaattacaa agagaattat cgagaaaaac aatcggtagt
     7741 ttaaatagaa ataaagcaag attaaaagtt gcaagacttc aagaacatat agctaatcaa
     7801 agaaatgatt ttctacaaaa actatctact aaattaataa aagagaatga tattatttgc
     7861 atagaagatt tacaagtaaa gaatatgatt aaaaatcata aactatctcg cttaatttca
     7921 gatgtatcat ggtcagaatt tattcgtcaa ttagaataca aggctaattg gtatggtaga
     7981 caaattgtaa aggtaggtaa attctttgca agttcacaaa tatgcaataa atgtgggtat
     8041 aaaaacgagg aagtgaagga cttaaatata agagaatgga tttgtcctag ttgtaatgaa
     8101 actcacgata gagatataaa tgcaagtata aatatattaa aagaaggatt aagactaata
     8161 acaattcaaa ataaataact tatgtaagaa ccgtaggaac tacggggatt gcctgtggag
     8221 aattagtaag acatatttta gtatgcaaaa ttctatgaag caggaaccct gtgactttag
     8281 tcatgggagg ttcagtttag cttaaaactt acttatctat ttcagtttct attagaatta
     8341 ttattagact cattaaaata aaagcactaa tataactaat aatatatgtt aaattcatta
     8401 actctacata aagttttaca atctaaatga aatacaataa tctgcataaa attcaatagc
     8461 ttatataaaa tttaataatt tatataaaca ttatcaatct atataaaatt tagtaattta
     8521 tataaatatt atcaacctat ataaaattta ataacttat
//
LOCUS       DAEPID010000121         8314 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.122, whole genome shotgun sequence.
ACCESSION   DAEPID010000121 DAEPID010000000
VERSION     DAEPID010000121.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 8314)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8314)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..8314
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.122"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            complement(182..577)
                     /locus_tag="KR257_003510"
     CDS             complement(182..577)
                     /locus_tag="KR257_003510"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893126.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HBH0032169.1"
                     /translation="MNRIKELREEKGISLDKLSEDLHINKSTLSRIENGLREPKKSTI
                     EEYANYFDVSTDYLLGRTDVRNSLFINKNEKDYDAENFKTEKELIENMYLDEDMKEVF
                     NIFSELSPDAREKALKVAELFLLDEKNKK"
     gene            756..989
                     /locus_tag="KR257_003511"
     CDS             756..989
                     /locus_tag="KR257_003511"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003433496.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF739 family protein"
                     /protein_id="HBH0032170.1"
                     /translation="MYLNRLEGLMKENRHTQKNVADILGLSSYGFRLKLKGKNEFKAS
                     EIKKISKLYNVSADYFFSDEVAKIAIKEERGNK"
     gene            989..1741
                     /locus_tag="KR257_003512"
     CDS             989..1741
                     /locus_tag="KR257_003512"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003433498.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Rha family transcriptional regulator"
                     /protein_id="HBH0032171.1"
                     /translation="MKNLTIIKQNNQFLVESREVAELIEKKHDNLLRDIRGYKKILED
                     SSNLKSQDFFIESTYINTQNKIQPCYLLTKKGCDMVANKMTGEKGIIFTAIYVTKFEE
                     MERELKEQQPKLPTTYKEALQQLLIEVEEKEQLQLENQVMKPKADYFDALVERNLLTN
                     IRDTAKELGVKEKTFVLWLIEKKYCYRDLKGKIKPYSNKMQYFELKEFTTPYGHSDTQ
                     TLINPKGREAFRLLLIKDGLVKEKEYQITLLG"
     gene            1786..2040
                     /locus_tag="KR257_003513"
     CDS             1786..2040
                     /locus_tag="KR257_003513"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009901708.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0032172.1"
                     /translation="MSEDIFYGIKNTLDEIAEVQIKNKQGVLKEVGMLISGEDNSCIT
                     HCLDEDLIKFYIKEEAVLTIDKDSHLLCMLDALFYNFLDK"
     gene            2068..2511
                     /locus_tag="KR257_003514"
     CDS             2068..2511
                     /locus_tag="KR257_003514"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015984880.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="HBH0032173.1"
                     /translation="MKKLGNISNFNLDKQEDKSFNDLDNISICFSEGIRKVVEMNLNN
                     YKNKISKYLNETSKIELLEPKELTIVISKGYPDYLMSVEEASKRLKIDKVFGYELIKN
                     GLLKSVDIGATKVSSYELDDFITRNQGKNIKEMLREMKELREGVI"
     gene            2639..2827
                     /locus_tag="KR257_003515"
     CDS             2639..2827
                     /locus_tag="KR257_003515"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009894683.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0032174.1"
                     /translation="MKIIYKNKVYKVEQDKKLFRITYYDEQRGSKKFNKEKKIKRSVL
                     TRDIELVNLYLPAHLKIK"
     gene            complement(2962..3132)
                     /locus_tag="KR257_003516"
     CDS             complement(2962..3132)
                     /locus_tag="KR257_003516"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0032175.1"
                     /translation="MSNKDIYTREEDKRFTLRINKLLFEKIEQLAQKDKRSIGREIEF
                     ILEKYFEDNPLE"
     gene            3275..3433
                     /locus_tag="KR257_003517"
     CDS             3275..3433
                     /locus_tag="KR257_003517"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903684.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Arc family DNA-binding protein"
                     /protein_id="HBH0032176.1"
                     /translation="MTNERVRFTFRLPAPLLEKIKNRASIEGSSMNSLILHILWDYIK
                     EIENKEVK"
     gene            3433..3660
                     /locus_tag="KR257_003518"
     CDS             3433..3660
                     /locus_tag="KR257_003518"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009894686.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0032177.1"
                     /translation="MVELVKEFDLQTIKVGNAVKVNCKRFGFEIDCIVVVATEKELNL
                     AYFDEGRGCMEYQALITEDIQDGDYEIKILS"
     gene            3758..4072
                     /locus_tag="KR257_003519"
     CDS             3758..4072
                     /locus_tag="KR257_003519"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009901712.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0032178.1"
                     /translation="MESLKRIKKMVQKQLVLAELEINKNSKLYEELENKDRGLIDDIH
                     MREYLREKVAWERVKYAIENILGGINLEIKSKEHEESEDYKIFQLILEELERDKPIDV
                     QI"
     gene            4156..4665
                     /locus_tag="KR257_003520"
     CDS             4156..4665
                     /locus_tag="KR257_003520"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861752.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="siphovirus Gp157 family protein"
                     /protein_id="HBH0032179.1"
                     /translation="MSTLYELTTDLLEIEEGLTETTGNETEKLEEIKEIIKQEIQNKN
                     TRIVSVILNIDSDINSIDSEIKRLQELKRVKKNTLDRLKSNIKDCMELLGTKKVETVL
                     GNISIRKSAGSLVIEDEEKIPAIYKTVEQVVKVDKNIIKDFIKKGHEVEGCRIEYGTT
                     LTIPKAKKE"
     gene            4675..5283
                     /locus_tag="KR257_003521"
     CDS             4675..5283
                     /locus_tag="KR257_003521"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015984885.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ERF family protein"
                     /protein_id="HBH0032180.1"
                     /translation="METNNVYIKLVNIQSTLKAPKSQFNSFGKYNYRSCEDILEGLKP
                     ILKEEKALVILDDNIVQIGNRFYVEATATLIDAETGEKVSTKALAREDETKKGMDLAQ
                     VTGSVSSYARKYALNGLFCIDDTKDSDATNKHGNEQKKKEVNESELNTLYSLGESIEK
                     DKNRVDSEVYKKFGKLAVDLTKQEYEKVLNGYKSILEKQKQE"
     gene            5293..6174
                     /locus_tag="KR257_003522"
     CDS             5293..6174
                     /locus_tag="KR257_003522"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016056364.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DnaD domain protein"
                     /protein_id="HBH0032181.1"
                     /translation="MGIIRVSKDKDNPYVVLNKTCLEDVKLSWQAKGLHSYLISKPDH
                     WKIYVNDLCKRSKNGRDATANILKELIENGYITRKPCRDSNTNKMLGGYDYEVYEIPL
                     ENPQKLKSRKTDFPETGFPGNRVSRKPENTEVVSNDFKVNNDITTIVINEQSNKDKTT
                     YIKKYFEKYIGVITPNNFIELMSYLDDGMEADVIIRAVDEAVGSGVKNYKYVKTILNN
                     WIEAGVKTVLELTEYQNEFERKKKSKQEKKQSNSKTVNTHNVNKNKFANFNQTFTQYE
                     EKELDEIIKKSQKEKFK"
     gene            6235..6408
                     /locus_tag="KR257_003523"
     CDS             6235..6408
                     /locus_tag="KR257_003523"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861749.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="resolvase"
                     /protein_id="HBH0032182.1"
                     /translation="MARIYAQRSGSLNEQDRLELLRLLGKAGYTVKVAREKQNSKTTY
                     TYFVEYTEEQEEK"
     gene            6424..6831
                     /locus_tag="KR257_003524"
     CDS             6424..6831
                     /locus_tag="KR257_003524"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009901717.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="single-stranded DNA-binding protein"
                     /protein_id="HBH0032183.1"
                     /translation="MNTITLVGRLVADAELKYLPNSGTPKITFSMAVDRRFKDKNGNK
                     ITDFIQCEQLGKHVENLVQYLVKGKPIYAVGELNIYNYKDENGCWKSITKVNVNALEL
                     LSSKNDNNAKQEYVPPGLDPQGFQAIDDDDIPF"
     gene            6905..7099
                     /locus_tag="KR257_003525"
                     /pseudo
     CDS             6905..7099
                     /locus_tag="KR257_003525"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861747.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
     gene            7151..7408
                     /locus_tag="KR257_003526"
     CDS             7151..7408
                     /locus_tag="KR257_003526"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428911.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0032184.1"
                     /translation="MIIIRSQDKTDLVKADWINVDKECVYAMFGDMDNFKKIGEYEDE
                     KRAIQVLDNIQRFIEGGTRTDSIDSYKVRSYRNRIFQMPVK"
     gene            7422..7787
                     /locus_tag="KR257_003527"
     CDS             7422..7787
                     /locus_tag="KR257_003527"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015994375.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0032185.1"
                     /translation="MLKVEKYFSGSLGTNIIDDDPTCRNYLALYCCVHGVRKNGELIF
                     PTCEKMLIEFNVDKNRKKKKKGSKVKLINAKTGEEKIFDSIDSAACFLRLQSQAVYQT
                     IKKKTKTRSGWKAEYIEEE"
     gene            7905..8240
                     /locus_tag="KR257_003528"
     CDS             7905..8240
                     /locus_tag="KR257_003528"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015981539.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0032186.1"
                     /translation="MNILASVILVIGSFIAGRVYEYRLNLNENDEADSKVLLDVFNEI
                     SVLREENKSLKEKLQEKELLFINRLIDFLHDKKICECCIYDCKIDDIEYDCEDGIKKW
                     LDSEELIFE"
BASE COUNT         3549 a          806 c         1511 g         2448 t
ORIGIN      
        1 gatatatttg aataagacga aatattatga tattttaaag ttaaacttat taatgaaaaa
       61 gttgaaagaa ttggataaaa ataaaatcaa tgaatataaa ataaaagtga aagaaataca
      121 taaaatcaat aaaaaagagg aatgattcct cttttttatt atattcattt tcagaaataa
      181 actatttttt atttttttcg tctagtaaaa ataattctgc aacttttaat gctttttctc
      241 ttgcgtctgg gcttagctcg ctaaatatat taaaaacttc tttcatatct tcgtcaagat
      301 acatattctc aataagctcc ttttctgttt taaaattttc agcatcataa tctttttcgt
      361 ttttatttat aaataagcta tttctaacat cagttcttcc taataaataa tctgtagaca
      421 catcaaaata gtttgcatat tcttctattg tacttttctt aggttctctt aaaccatttt
      481 ctatccttga tagtgtagat ttgtttatat gtaaatcctc gcttaatttg tctagcgaga
      541 tgcctttttc ttctctcaat tcttttatcc tattcaattt gcacaacccc tttttatatt
      601 aattccaaaa tagcaacttt tatttatatt atagcaacaa aattaattat tacaattttt
      661 tttgctaaaa aagcaacaaa agtattgact ataatcacaa aacttgatat tatataaata
      721 tgaagttgcc aaaatagcaa aaaggaagtg atttaatgta cttaaataga ttagaaggat
      781 tgatgaagga aaatagacac acccaaaaaa atgtggcaga tatattaggt cttagctcat
      841 atggttttag attaaaatta aaaggaaaaa acgaatttaa agcaagtgaa ataaaaaaga
      901 tatctaaatt atataatgta tctgcggatt attttttttc agatgaagtt gctaaaatag
      961 caataaaaga agaaaggggc aataaataat gaagaatcta accataatca agcaaaataa
     1021 tcaattttta gttgaaagta gagaagtagc agaattaata gaaaagaagc acgataattt
     1081 attaagagat ataagaggat acaagaagat tttagaggac tcatcaaatt tgaagagtca
     1141 agatttcttc atagaaagta cttatataaa tactcaaaat aaaattcaac cttgctactt
     1201 attaactaaa aaaggttgtg acatggtagc taataaaatg acaggtgaaa agggaattat
     1261 atttacagcg atttatgtaa ctaagtttga agaaatggag cgagagttaa aagaacaaca
     1321 acctaaatta ccaactacat ataaagaagc actgcaacag ttattaatcg aagttgaaga
     1381 aaaagagcaa ttacaattag aaaatcaagt aatgaaacca aaagcagatt actttgatgc
     1441 tctagtagaa agaaacttgc taactaatat aagagataca gcaaaagaac ttggagtcaa
     1501 agaaaaaaca tttgttttat ggttaataga gaagaaatat tgttacagag atttaaaagg
     1561 caaaataaaa ccttactcta acaagatgca gtattttgaa ctgaaagaat ttacaacacc
     1621 atacggacat tcagatactc aaacattaat aaatccaaaa ggaagagaag catttagatt
     1681 attacttata aaggatggac tggtaaaaga aaaagaatat caaataactt tattaggcta
     1741 aaattgaaag tactttgaaa attaaagatt atggaggtag ttacaatgag cgaagacata
     1801 ttttatggta taaaaaatac tcttgatgaa atagcagagg ttcaaattaa aaataaacaa
     1861 ggtgtgttaa aagaagttgg aatgttaata agtggtgagg acaattcttg tataacgcat
     1921 tgtttagatg aagatttaat taagttttac ataaaagaag aggcagtatt gacaatagat
     1981 aaagatagtc atttgttatg tatgcttgat gctctatttt ataactttct tgataaataa
     2041 taaatacaga atattcttga aatggtggtg aagaaattgg gtaatatatc taactttaat
     2101 ttagataaac aagaagataa aagttttaat gacctggata atatatcaat ttgtttttca
     2161 gaaggtattc gtaaagttgt agaaatgaat ttaaacaact ataaaaataa aatctcaaaa
     2221 tacttaaatg aaacttcgaa aatagaattg ttggaaccaa aagaattaac aattgttata
     2281 agtaaaggtt atcccgatta tcttatgtct gttgaagaag caagtaaaag attgaaaata
     2341 gataaagtat ttggatatga gttaataaaa aatggacttt tgaagtcagt tgatataggg
     2401 gcaactaaag tttctagtta tgaattagat gattttataa ctaggaatca aggaaaaaac
     2461 atcaaagaaa tgcttagaga aatgaaagaa cttagagagg gggtgattta attggaacta
     2521 gtaacataca gaaacaagct tgttttacta aaagatggag aaaagattgc aactataagt
     2581 ttaaaaagga aatttctcag caacagactt aaattaaaaa taagatagga gagataaatt
     2641 gaaaataatt tataaaaaca aagtttacaa agtagaacaa gacaaaaagt tatttagaat
     2701 tacatactat gatgagcaga gaggtagtaa gaagtttaat aaagagaaga aaataaaaag
     2761 aagtgtttta acaagagata tagagttagt taacttgtat ttaccagcac atttaaaaat
     2821 aaaataagct ataaataatt aaagaaaaag gtgattagat ggaaatagaa caagcaacaa
     2881 tacgcctgcc tagagaactt aaagacaagc ttctaaaaca ggcaaaagtt aaaggatata
     2941 cattaaaaga tatgatagtt tttattctaa aggattatct tcaaaatatt tctcaagaat
     3001 aaattcaatt tctctaccta tagaacgctt atctttttga gcaagttgtt cgattttctc
     3061 aaaaagaagt ttattaattc ttagtgtaaa tcttttatcc tcttcacgag tataaatatc
     3121 tttattagac atatttatca ttcctcacat aaaatttgac gtctttatga cactttaata
     3181 ataaaataat ataaaagaaa agtcaacaaa aatgcttgac gtcaaatata tgacatggta
     3241 ttattaaaac aagaagggag ttgacgtcaa atatatgaca aatgaaagag ttagatttac
     3301 atttagatta ccagcaccat tgcttgaaaa aattaaaaat agagcatcaa tagaaggtag
     3361 ttcaatgaac tcacttatat tacacatact ttgggattac ataaaagaaa tagaaaataa
     3421 ggaggtcaaa taatggttga attggtaaaa gaatttgatt tacaaacaat taaagtagga
     3481 aatgcagtaa aagtaaattg caaaagattt ggttttgaaa ttgattgtat agtagtagta
     3541 gcaacagaaa aagaattaaa tttagcatac tttgatgaag gtagaggctg tatggagtat
     3601 caagccttaa taacagaaga tattcaagat ggtgattatg agattaaaat tttatcttag
     3661 gaggaaataa aatggctgct ttaataatgg taggtttatt tgcaatatgt ttagtaggat
     3721 tagttcaaaa tagagattaa attaaggggg attaattatg gaaagtttaa aaagaataaa
     3781 aaaaatggtt caaaaacaat tagttttagc tgaattagag ataaacaaaa atagcaaact
     3841 ttatgaggaa cttgaaaata aggatagagg tttaatagat gatatacaca tgagagaata
     3901 tctaagagaa aaagttgcat gggaaagagt aaaatatgct attgaaaata ttttaggtgg
     3961 tataaattta gagattaaat caaaggaaca tgaagaaagt gaggattaca agatatttca
     4021 attaatttta gaagaacttg aaagagataa acctatagat gttcagatat aagaaaagag
     4081 ccattgccgt ggctcaattc aaataaatat atcaaaattt aattaagcta attatagcac
     4141 aaacggaggg aaattatgag tactttatat gaattaacta cagatttatt agaaatagaa
     4201 gaaggtttaa cagaaacaac aggaaatgaa actgaaaaac tagaggaaat aaaagaaata
     4261 ataaaacaag agatacaaaa taaaaacact aggatagttt cagtaatatt aaacattgac
     4321 agtgatataa actctataga ttcagagatt aaaagactgc aagagttaaa aagggtcaaa
     4381 aagaatactc ttgatagatt aaaaagcaat ataaaagact gtatggaatt acttggtact
     4441 aaaaaagtag aaacagtttt aggaaatata agtataagaa agtcagcagg tagcttagtc
     4501 atagaagatg aagaaaagat acctgctata tataaaacag tagagcaagt tgtaaaagta
     4561 gataagaata tcattaaaga ctttattaaa aaaggtcatg aggttgaagg ttgcaggatt
     4621 gaatatggaa ctacactaac aattccaaaa gctaaaaaag agtaggtgag gaccatggaa
     4681 actaataatg tttatataaa acttgtaaat atacagagta ctttaaaagc tcctaaaagt
     4741 caatttaata gctttggtaa atacaactat aggagttgtg aggatatact agaaggttta
     4801 aaacctattc taaaggaaga aaaagcatta gttatattgg atgataatat tgttcagata
     4861 ggaaatagat tttatgtaga agctacagca actttaatag atgcagaaac aggagagaaa
     4921 gtatctacaa aggcattagc tagagaagat gaaactaaaa aaggtatgga tttagcacaa
     4981 gtaactggaa gtgtatcaag ttatgcaaga aagtacgctt taaatggatt attttgtatt
     5041 gatgatacaa aagatagtga tgcaacaaat aaacatggaa atgagcagaa aaaaaaagaa
     5101 gttaatgaga gtgaattaaa tacactatat tcgctaggag aatctataga aaaagataaa
     5161 aatagagttg atagtgaagt atataagaag tttggaaagt tagcagtaga tttgactaag
     5221 caagagtatg agaaagtttt aaatggatat aagagcattt tagagaagca aaaacaagag
     5281 taggtgatag tattggggat tataagagta agcaaagaca aagataatcc atatgtagtt
     5341 ttaaataaaa cttgtttgga agatgtaaaa ttaagctggc aagcaaaagg tttacattca
     5401 tatctgatta gtaagcccga ccactggaaa atctatgtta atgacctttg caagagaagt
     5461 aaaaatggaa gagatgctac agcaaatatt ttaaaagaac ttatagaaaa tggatatata
     5521 acaagaaaac cttgtagaga ttctaatact aataaaatgc ttggagggta tgattatgaa
     5581 gtatatgaga taccacttga aaatcctcag aagctaaaat cccgaaaaac tgatttcccg
     5641 gaaaccggat ttcccggaaa ccgggtttct cggaaaccgg aaaacacgga agtagtaagt
     5701 aatgacttta aagtaaataa tgatattact actattgtta ttaatgaaca atccaataaa
     5761 gacaaaacca cctatataaa aaaatacttt gaaaaatata taggtgtgat tactcctaat
     5821 aactttatag agttaatgag ttacttagat gatggaatgg aagctgatgt aataataaga
     5881 gctgttgatg aagctgtagg cagtggagtt aagaattata agtatgtaaa gacaatctta
     5941 aataattgga tagaagcagg tgtaaaaact gttttagaac ttacagaata tcagaatgaa
     6001 tttgaaagaa agaaaaagag taagcaggaa aagaagcagt ctaatagtaa aactgtgaat
     6061 actcataatg tgaataaaaa taagtttgct aacttcaatc agactttcac tcaatatgaa
     6121 gaaaaagagc tagatgagat tattaaaaag agtcagaagg aaaaatttaa ataaaattaa
     6181 acttctagga agtaaatatc aatatattgc ttcctagaaa aggggaggta taaaatggcg
     6241 agaatatatg cacaaagaag tggttcttta aatgaacaag atagattgga gttattaaga
     6301 ttacttggga aagctggata tacagtaaag gttgctagag agaagcaaaa tagcaagaca
     6361 acttatactt actttgttga gtatacagaa gaacaggaag aaaaatagaa gggggctagt
     6421 taaatgaata caataacttt agttggaaga ttagttgcag atgcagaatt gaagtacctt
     6481 ccaaattcag gtactccaaa aataaccttt tcaatggcag tagatagaag gtttaaagat
     6541 aaaaatggaa ataaaataac tgattttatt caatgcgagc aattaggaaa acatgtagag
     6601 aatttagtgc aatatcttgt taaaggtaag cctatatatg ctgttggaga gttaaatata
     6661 tataattaca aagatgaaaa tggttgctgg aaatctatta ctaaggttaa tgtaaatgct
     6721 ttagaactac tttctagtaa aaatgataat aatgctaaac aagaatatgt accaccagga
     6781 ttagacccac aaggttttca agcaatagat gatgacgata taccttttta attaagttaa
     6841 ataatctagg gagtaattat gcaatattac ttcctaggag ttaaaaaata ttggaggttt
     6901 aagagtgaaa tatgagtgtg agaaagtgtt cttagaatgc gataagggaa gttttgagat
     6961 aaatgataca agagctgaag aagtaacatt cgagggtaca gaaatagaca atctgtttga
     7021 gagagtaaaa tatgaaggga cttttacaat aatatctgga tgggattctt tattgagaga
     7081 tatattgtgg cttgaaatgc ggaaagtctt aaaaattata acaggaaaaa tgatgatggg
     7141 ggtattagga atgataataa ttagaagtca agataaaact gatttagtaa aagctgattg
     7201 gataaatgtt gataaagaat gtgtatatgc aatgtttgga gatatggata actttaaaaa
     7261 gataggtgag tatgaggatg aaaaaagggc tatacaagtg ctggataata tacaaagatt
     7321 tattgaaggt ggaactagaa cagattctat agacagttat aaggttagaa gttatagaaa
     7381 tagaatattt caaatgccag ttaaataggg aggttactga aatgttaaag gttgaaaaat
     7441 attttagtgg ttctttagga acaaatatca tagatgatga ccctacatgt agaaattact
     7501 tagcactata ttgttgtgtt cacggagtaa gaaaaaatgg agaacttata tttccaacat
     7561 gtgaaaaaat gttaatagag tttaatgttg ataaaaatag aaaaaagaaa aagaaaggtt
     7621 caaaggtaaa gttgattaat gccaaaactg gtgaagaaaa aatatttgat tctatagata
     7681 gtgcagcatg ttttttaaga ctacagagtc aggcagttta ccaaacaatt aaaaagaaaa
     7741 ctaaaacaag aagtggctgg aaagctgaat atattgagga ggaataatgg aagtttcaag
     7801 gactgaatac acaattaaaa gagcaaaaga gttatatgat aatggagagg atatatttat
     7861 tgctatagat aaggctagag aagaatatga ggagatggtt aaaagtgaat atcttagcta
     7921 gtgtgatatt agtaatagga agttttatag ctggtagagt ttatgagtat agattgaatt
     7981 taaatgaaaa tgatgaagct gattcaaaag tacttttaga tgtttttaat gaaattagtg
     8041 tgttaagaga agaaaataaa agccttaaag aaaagttaca agagaaagag ttactattca
     8101 tcaatagatt aatagatttt ttacatgata aaaagatatg cgaatgttgt atttatgact
     8161 gtaagattga tgatattgaa tatgattgtg aagatggtat taaaaagtgg cttgatagcg
     8221 aagaacttat atttgaatag aagaaatatc taattaaaac agtttagaga gttgcaaaat
     8281 gttttttaat aaaattatca ttgagatgtt ttgt
//
LOCUS       DAEPID010000122         8137 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.123, whole genome shotgun sequence.
ACCESSION   DAEPID010000122 DAEPID010000000
VERSION     DAEPID010000122.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 8137)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8137)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..8137
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.123"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            179..1630
                     /locus_tag="KR257_003529"
     CDS             179..1630
                     /locus_tag="KR257_003529"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454468.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alanine:cation symporter family protein"
                     /protein_id="HBH0032187.1"
                     /translation="MDFFNGILTSINNAVVFVNNYLWSYILIIMLVVIGIYFTIKTNF
                     VQFRYFIEMFRLLGDGTANKNAKKEGKISSFQAFCISTSSRVGTGNIAGIAIAVVAGG
                     PGAVFWMWLIALIGSASSFVESTLAQIYKVKDGQAFRGGPAYYMEQGLNKKWMGILFS
                     ILITICYGFVFNAVQANTVSLAFNNAFGISKMAMGIGLGILTAIVIFGGVHRVAKVSE
                     IIVPVFAGLYILVALAIVVMNITEIPSVIALIVESAFDFKGMAIGTFMGVVMTGVKRG
                     LFSNEAGMGSAPNAAATAHVTHPVKQGLIQSLGVFTDTIIICSCTAFMVLLYSGYSSS
                     GATGIELAQEALTHHIGPVGNIFIAVCIFLFAFSSIVGNYYYGESNMEFMSGSKTKLN
                     VFRVFVVGMVLFGSLTQVDVVWNLADLFMALMAIINLIAIALLGKYAFIALKDYTSQK
                     KSGIKDPVFIADEIEGLEKVSEWHRELSEEHLG"
     gene            complement(1828..2469)
                     /locus_tag="KR257_003530"
     CDS             complement(1828..2469)
                     /locus_tag="KR257_003530"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007491147.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PAS domain-containing protein"
                     /protein_id="HBH0032188.1"
                     /translation="MTDNYIFDSYNNLVDGLSAYLGEGYEFILYKFNGVHYSINKIAN
                     GKYNTVKEGDIITDFDLALISKLENDADGDFISYFNRNKLGEPLKSTDIVIRGVDNKI
                     IGLLCIHFYLNTPLTRIIGSYIPEHNAMQSAPVLENIVEDTDEVILKSYQDAKVIVEN
                     DSNISSNDKNKSIVSILNESGIFKIKDSVVKVADLMGLSKNTIYMHLRNLNKN"
     gene            2943..4322
                     /locus_tag="KR257_003531"
     CDS             2943..4322
                     /locus_tag="KR257_003531"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016290023.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS transporter subunit EIIC"
                     /protein_id="HBH0032189.1"
                     /translation="MAQDKIVVEILENIGGKENIKEVAHCMTRLRIKVCDSSQVNQEK
                     LKKIKGVLGLVLKGEQYQIVIGPNVSQVYNTLNEVIGIIPEKDSKKTISEGKQNSIAK
                     ILDTIAGIFNPIVPALAGAGLIKAILALLVASKFLSADSETYIILNTISDGVFSFLPF
                     MLAYSAAKIFKMNTYVAVAIAGAMLHPNFINLIQQGLTKISFIGIPMSLIQYNGSVFP
                     IVLTIWFASYIEKGVDKITPKALKIILVPALTILFAAPIALIIIGPIAQMLGNYIAGG
                     ASILFERGGIFAGLIYGGIYSFMVVTGLHHGMVPVLVDGITRYGFNYISPVSGSSNMA
                     QAGSAFGVWLKAKDKDLKAVAATATISALTGVTEPAIYGVNLRLKKPFLCAAIGGAAG
                     GGFAAYFQCKAFAMGGPSFLTLPMFIGEGGHVGLVAIAFTIAFIVSAIATYIVGFEEE
                     VTADSHANL"
     gene            4366..5100
                     /locus_tag="KR257_003532"
     CDS             4366..5100
                     /locus_tag="KR257_003532"
                     /EC_number="3.5.99.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010990049.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glucosamine-6-phosphate deaminase"
                     /protein_id="HBH0032190.1"
                     /translation="MKIYLTKDYEEMSQVAAQMVLKYMYSNDNKRINLSITAGQTPKR
                     TYEILSEFVKNKPYFENVHYYNFDEIPIKGEKVGVTIRNLTNMYFREAQIPEERIHVL
                     DENNYQGFDRKIEADGGIDMVLMGLGWDGHFCGNLSGTVNSFDEETRAVSTYITDDMA
                     KLLTKSVGGNPEKLFDYYVTYGPKTIMHCKNIIMIVNGKHKAQILKQTLFGPLDLLCP
                     SSLLRLHPNFTLIVDEEAASEIKDLI"
     gene            5189..6388
                     /locus_tag="KR257_003533"
     CDS             5189..6388
                     /locus_tag="KR257_003533"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006875852.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pyridoxal phosphate-dependent aminotransferase"
                     /protein_id="HBH0032191.1"
                     /translation="MYNHMKKVFQGLEGGLFSSVEKADVGDSYQKLGEQGVSLMGWAD
                     PFFPDYCIPRHILDAATLAISSNMSTHYTAPVGNDLLKIEIAEKLKEVNNLDVDFKRN
                     ILITPGSDSGLYYSMLPFINEGDEVLIPTPCYPNNIQNTKLMGGVPIFVELKESDGYQ
                     IDITEFEKRLTNKTKLVVLTHPNNPTTTIFNKESLEKLAKFIIDNDLILICDQAFEDF
                     TFENELITPASLEGMFERTVTIFSTSKGMGLSGFRVAYMVCSDKLMDKYYGAAVTVLG
                     ATNTVAQMSTIEAFKDRSFMEDFERVFDKRRQEAYKIINEIPNVSMQMPESGFLGWIN
                     VSKLGTSSEIQKYLVDEAKVCINDGINYGPGGEGHLRIILGSYKDDSKVIGALNRIKD
                     ALIKKQQ"
     gene            6412..6894
                     /locus_tag="KR257_003534"
     CDS             6412..6894
                     /locus_tag="KR257_003534"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015529974.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS glucose transporter subunit IIA"
                     /protein_id="HBH0032192.1"
                     /translation="MLSIFKSKKNDNKLKAFASGKVIPIEDVDDNVFSSKMLGDGIAI
                     YPTNEYVVAPCDAEVNIIMKDTKHAVGIKLFNGMEILFHVGIDTVSMNGEGFEIFVSP
                     GDKIKRGDKLISFNSKLIKEEGLQDVVIMVVTNSEQYKNIKYHIGLEAVIDDTIIAEI
                     "
     gene            complement(7212..7809)
                     /locus_tag="KR257_003535"
                     /pseudo
     CDS             complement(7212..7809)
                     /locus_tag="KR257_003535"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012816433.1"
                     /note="frameshifted; internal stop; incomplete; partial in
                     the middle of a contig; missing C-terminus; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
BASE COUNT         3009 a          931 c         1365 g         2832 t
ORIGIN      
        1 aaggtttgat ttgaatataa aactgcaata tattaaaaaa attattcatt ttaaaccttg
       61 taatttgatt ttataaatat tataattaaa ttaatgaatt tttaacaagg aattattcat
      121 ttttttgatt ttaagattta ttgagaaaac aaaactaaat aggggggtaa ttaatataat
      181 ggattttttc aatggtattt taacgagtat taacaatgca gtagtatttg taaacaatta
      241 cttatggtcg tatatcttaa ttataatgtt agttgtaatt ggtatttact ttactattaa
      301 aacaaatttt gtacaattca gatattttat agaaatgttt agacttctgg gtgatggtac
      361 agcgaataaa aatgcaaaaa aggaaggaaa aatctcttca tttcaagcat tttgtataag
      421 tacatcttca agagttggaa ctggaaatat agctggaata gcaattgcag tggtagcagg
      481 aggacctggt gctgtatttt ggatgtggct tatagcatta attggttctg catcaagctt
      541 tgttgagagt acattagctc agatttacaa agtgaaagat ggtcaagctt ttagaggtgg
      601 accagcgtat tatatggaac aaggtctaaa taaaaaatgg atgggtattt tattctcaat
      661 acttataact atatgttatg gttttgtatt taatgcagtt caagcaaata ctgtttcact
      721 tgcatttaat aatgcatttg gaataagtaa aatggctatg ggaataggtc ttggaatttt
      781 aactgcaata gttatttttg gtggagtgca tagagttgca aaagtttctg aaataatagt
      841 tcctgtattt gcaggattat atatattagt tgctttggct atagttgtaa tgaatataac
      901 agagatacca agtgttatag cattgatagt tgaaagtgca tttgatttta aaggaatggc
      961 gattggtaca tttatgggag ttgtaatgac tggagtgaag agaggtctat tttctaatga
     1021 agcaggtatg ggtagtgctc ctaatgctgc tgcaacagca catgtaactc atcctgtaaa
     1081 acaaggttta attcaatctt taggtgtttt tacagatact ataataatat gtagttgtac
     1141 agcattcatg gtattattat attcaggtta tagtagtagt ggagcaactg gaattgaatt
     1201 agctcaagaa gctttaactc atcatatagg accagttgga aatatattta tagcagtttg
     1261 tatattcttg tttgcattta gttctatagt tggtaattac tattatggtg aatcaaatat
     1321 ggagtttatg agtggaagta agactaaact taatgtattt agagtttttg ttgtaggtat
     1381 ggttttattt ggttcactta ctcaagtgga tgtagtttgg aatcttgcag acttatttat
     1441 ggcattgatg gcgataataa acttaatagc aatagcactt ttaggaaaat atgcatttat
     1501 tgctttaaaa gattatacaa gtcaaaaaaa atcaggaata aaagaccctg tgtttattgc
     1561 agatgaaata gaaggcctag aaaaggtatc agagtggcat agggaattat ctgaggaaca
     1621 tttaggataa aaaatagtat aaaattataa aaccattttg aaagactaga gtatgtatat
     1681 actttatatg aatataatat tgaattaatt tatattactg gaatttttaa ttccagtaat
     1741 atttttttaa ttacaaggat attatgatga cttaaagact gtggaaaact cttttttagt
     1801 tttcattatt aatattaatt gacaaattta gtttttattt aaatttctta agtgcatata
     1861 aatcgtattt tttgataatc ccattaagtc tgcaacttta acaacagaat ccttaatttt
     1921 aaaaatacca ctttcattta aaatagaaac aatagattta tttttatcat tgctagatat
     1981 attagaatca ttttcaacaa ttacctttgc atcttggtat gattttaaaa ttacttcatc
     2041 agtatcttct acgatatttt ctaaaacagg agcactttgc atagcattat gttccggaat
     2101 atatgaacca attattcttg ttagtggtgt attaagataa aaatgtatgc agagtagacc
     2161 gattatttta ttatcaactc cccttatcac tatatctgtt gattttaaag gttcacctag
     2221 tttgtttcta ttaaaataac tgataaaatc tccatcagca tcattttcga gtttactaat
     2281 gagtgccaaa tcaaaatcag ttataatatc tccttctttt acagtattat atttaccatt
     2341 agctatttta tttattgaat agtgtactcc attaaattta tataaaataa actcgtatcc
     2401 ttctcctaaa tacgcagata atccatccac tagattgtta taagaatcga aaatatagtt
     2461 atcagtcatg ttaaaagtca tatgttacct cctaagaaat atcttaatat catattaaca
     2521 tataaaatga atttaataaa atatatttca gtgaaataat aaatataatg aaaaaaaaac
     2581 tattgactga aaaatatttc agtgatatta ttaaaataca gtaaggcaaa cgtattattg
     2641 acagaatata taaaatgtta aaaatagtat ctaggaatta aacaaattaa aggactagtg
     2701 atttgaattt ttttagtata atatgtgact tccaattaat atttattaaa caccaataaa
     2761 attgtaaata tgcttaatga tatactttag cgatgaagtg aaaatatttt atttttatga
     2821 ttaacctata ggaattaatt tagcatactg tttagctagt aaatctaaat aaattttagc
     2881 tttagctgat atcatgttga ataaagtttc tattggattt tgtataacaa aggagtgggg
     2941 agatggcaca agataaaatt gtggttgaaa ttttagaaaa cattggtggt aaggaaaata
     3001 ttaaggaagt agcacattgt atgactagac tgagaataaa ggtatgtgat agttctcagg
     3061 taaatcagga aaaactaaag aaaataaaag gtgtactagg tcttgtatta aaaggtgagc
     3121 aatatcaaat tgttataggt cctaatgtat cacaagtgta taatactctt aatgaagtta
     3181 taggaattat acctgagaag gatagtaaaa aaacaatatc tgaaggtaaa caaaatagta
     3241 ttgcaaaaat attagatact attgcaggta tttttaatcc tatagttcca gcattagcgg
     3301 gtgcaggtct aataaaagct atattagcat tactagtagc atcaaagttt ttatctgcag
     3361 atagtgaaac ctatataata ttaaatacaa tatctgatgg tgtattttca tttttaccat
     3421 ttatgttagc ttactcagca gctaaaatat ttaaaatgaa tacttatgtt gctgtagcaa
     3481 tagcaggagc aatgctacat cctaatttca ttaatttaat tcaacaaggc ttaactaaaa
     3541 tatcttttat cggtattccg atgtcactaa tccagtataa cggaagtgta tttccgatag
     3601 tactaactat ttggtttgca tcgtatatag aaaaaggagt agataaaata acaccaaagg
     3661 cacttaagat aatattagta cctgcattga ctattttatt tgcagctcct atagcattaa
     3721 ttattattgg accaatagct caaatgctag gaaactatat agccggtgga gcaagtatcc
     3781 tatttgaaag aggaggaata tttgcagggt taatttacgg aggaatttat tcattcatgg
     3841 tagtaacagg attacatcat ggtatggttc ctgtattagt agatggaata acaagatatg
     3901 gatttaacta tataagtcct gtgtcaggta gttcaaatat ggctcaagca ggatctgcat
     3961 ttggagtatg gttaaaagca aaagataaag atttgaaggc tgtagcagct acagctacca
     4021 tatcagcatt aactggagtt accgaacctg caatatatgg tgttaattta agattaaaga
     4081 aaccgttttt atgcgctgct ataggtggtg cagcaggagg tggatttgct gcatatttcc
     4141 aatgtaaagc atttgctatg ggaggtccat cgtttttaac tcttcctatg tttataggag
     4201 aaggtggaca tgtaggattg gtagcaatag catttacaat agcatttata gtatctgcaa
     4261 tagctaccta tatagtagga tttgaagaag aggtaacagc agattcacac gctaacttat
     4321 aataaagaga aattatttaa catatcaaaa aggagattaa ttactatgaa aatttattta
     4381 actaaagatt atgaagaaat gagccaagtg gcagcacaaa tggtgttaaa gtatatgtac
     4441 agcaatgata ataaaagaat aaacctttct ataacagcag gtcaaacacc aaaaagaaca
     4501 tacgaaatat taagtgaatt tgttaagaat aaaccttatt ttgaaaatgt acattattat
     4561 aactttgatg aaataccaat aaaaggcgaa aaagttggag ttactataag aaatttaact
     4621 aatatgtact ttagagaagc tcaaatacca gaagaaagaa tacatgtgtt agatgaaaat
     4681 aattatcaag gctttgatag aaagatagaa gccgatggtg gaatagacat ggtattaatg
     4741 ggattaggtt gggatggaca cttctgtgga aatcttagtg gtacagtcaa ctcttttgat
     4801 gaagagacaa gagctgtttc aacttatata acagatgata tggctaaact attaacaaaa
     4861 tctgtaggtg gaaatccaga aaaattattt gattactatg tgacatatgg acctaaaaca
     4921 ataatgcatt gtaaaaatat aataatgata gtaaacggaa aacacaaagc tcaaatatta
     4981 aagcaaacac tatttggacc attagattta ttatgtccat catctttatt gagattacat
     5041 cctaacttca cattaatagt agatgaagaa gcagcatctg aaataaaaga tttaatataa
     5101 ataagtaagg aattaaaatt aaaaatgaat ttaggtgcaa agtaatattt tattttgcac
     5161 ctttgcttta ataaaaagga gaataaaaat gtataatcat atgaaaaaag tattccaagg
     5221 attagagggt gggttatttt caagtgtaga gaaagctgat gtaggcgatt cttatcaaaa
     5281 attaggtgag cagggtgtaa gtttaatggg atgggcagat ccatttttcc cagattactg
     5341 tatacctaga catatattag atgcagctac attagcgata tcaagtaata tgtcaactca
     5401 ttatacagcg cctgtaggta atgacttatt aaaaattgag atagcagaaa aattaaaaga
     5461 agtaaataat ttagatgttg attttaaaag aaatatatta ataactcctg ggtcagactc
     5521 agggctttat tactcaatgt taccgtttat aaatgaaggg gatgaggttc ttataccaac
     5581 accatgctat ccaaataata tacaaaatac taaattaatg ggaggagttc ctatatttgt
     5641 agagttaaag gaatcagatg gatatcaaat agatataaca gaatttgaga agagattaac
     5701 taataagacg aagttagtag ttcttactca tcctaataat ccaacaacta caatatttaa
     5761 taaagaatct ttagaaaaat tagctaaatt tattatagac aatgatttaa tattaatatg
     5821 tgatcaagca tttgaagatt ttacttttga aaatgaatta ataacaccag cttcattaga
     5881 aggtatgttt gaaagaacag taacaatatt ttcaacatca aaaggtatgg gattaagtgg
     5941 atttagagtt gcatatatgg tatgcagcga taaattaatg gacaaatact atggagcagc
     6001 agtgacagta ttaggtgcta ctaatacagt agctcaaatg tcaacgattg aagcatttaa
     6061 agatagaagc tttatggagg attttgaaag agtttttgat aaaagaaggc aagaagcata
     6121 taagataatc aatgaaatac ctaatgtatc tatgcagatg cctgagtccg gatttttagg
     6181 ttggataaat gtatcaaagc ttggaacatc atcagaaata caaaagtatc tagttgacga
     6241 ggctaaagtt tgtattaatg atggaattaa ttatggtcca ggaggagaag ggcatttgag
     6301 aataatttta ggaagctata aagacgatag taaggtaatt ggtgcattaa atagaataaa
     6361 agatgcttta attaaaaagc aacaataaat aaaaaataat tggagtggag tatgttatca
     6421 atatttaaga gtaaaaaaaa tgacaacaag cttaaggcat ttgcatcagg gaaagtaatt
     6481 cctatagaag atgttgatga taatgttttt tcatctaaaa tgttaggtga tggaatcgct
     6541 atttatccaa ctaatgaata tgttgtagcc ccttgtgatg cagaagtaaa tataataatg
     6601 aaagatacta aacatgcagt tggaattaaa ttatttaatg gtatggaaat cttatttcat
     6661 gttggaatag atactgtatc tatgaatgga gaaggttttg agatatttgt ttcaccaggt
     6721 gacaagataa aaagaggtga taaattaata tcttttaata gtaaattaat aaaagaagaa
     6781 gggttacaag atgtagttat aatggtagtt actaattcag aacagtataa aaatataaaa
     6841 tatcatattg gactggaggc agtaatcgat gatactatta ttgcagaaat ttaaaaacag
     6901 ttatttaagt aaatacttag ataatttaga tatagttaaa attaaatcct taaaatcaaa
     6961 ttatttaatt tttgtgtaat tttaactata aagccgatta ataatataaa gtatactaaa
     7021 taatatggtt attatgattg ttactgacaa agcctaagta gatataacaa tttgctctaa
     7081 ttgagtattg ctatatctac ttgtttttat atttaaaata aaagagtctg cattgaaaag
     7141 ataattctga tgagagtaaa tagggtattt aataatagtt taattctgac ttatcaagat
     7201 gaacctattc atatacctaa aacatcttta acaccttcta aattcataca aatagctgta
     7261 taggctgcct tattgattat ttttccgtca atttttactt tgtagtgaac agcatatata
     7321 aatattatcg aatagattgt atcaagagct ctattttgct attcattagc taaagatagt
     7381 actctgtcag ttatttttga aactaatgca tgagatatat caattccgta aatattattt
     7441 aaatgtatga tatatatcgc gagtcgacat tccttttgag tacatgccaa ttacttggtt
     7501 ctctattcca gaaatttcat tttcgtaatt ttgaataacc ctaggctgga aatcatccct
     7561 agggatattt aattttacct ctccaaaatc tgatttaaca ttcttagctc tatatccatt
     7621 tcttgaattt gatgttgctt tactttggtt atcatatctc tcgtacatta aatgatcttc
     7681 aatctctgac tctaacattt tgtgaattgt gcttgcgaat aaatctttta acatctcttg
     7741 gatgtcttta gtatttttta catcatactc ttgaactaag tgttttaata tttaattttt
     7801 gttgtacata aaaaatgtgt acctcctatt ttggtaatta gatttaatat cttgactttt
     7861 aggagaatac acattttatt ttacagaccc tcttttctag aaaagttttt atgaaaattg
     7921 tgatataaat tattaataaa aaataatttt atatttattt tattatgtaa tttagtttta
     7981 ttaaaaattt tttattattg gatatagatt atctattata aattttatct ttaagtttat
     8041 tctcctaaaa tactatataa ttaaatcctg taaattatct tcaaagcttt ctaggtaatc
     8101 acaaaataat ctaaattctt ctatggtttt aatttct
//
LOCUS       DAEPID010000123         8127 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.124, whole genome shotgun sequence.
ACCESSION   DAEPID010000123 DAEPID010000000
VERSION     DAEPID010000123.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 8127)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8127)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..8127
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.124"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            467..808
                     /locus_tag="KR257_003536"
     CDS             467..808
                     /locus_tag="KR257_003536"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889774.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LytTR family transcriptional regulator"
                     /protein_id="HBH0032193.1"
                     /translation="MKEENFINVEYEDKRFSINSKEVLYIEKQEYEVKIYTESGNYEV
                     GENAPCIRKLLKEENFFKCSNSYIVNLDKCEFYLSNNCIFVNNNFIRILGSERKKKLK
                     KKLEKLYDYED"
     gene            959..1372
                     /locus_tag="KR257_003537"
     CDS             959..1372
                     /locus_tag="KR257_003537"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897017.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1653 domain-containing protein"
                     /protein_id="HBH0032194.1"
                     /translation="MLELKNNLGISERKLKYPCIYKHFKGKYYATMGLSKAIDHIENI
                     CEIYGKENLIQNRNKYKLVIRHTEREEDIYVYRDLDGNFYHKKEEDTNDLVLYKTLYD
                     DTGIFARPLDMFLEKVDTDKYVNSIQEYRFEEVYK"
     gene            1574..2215
                     /locus_tag="KR257_003538"
     CDS             1574..2215
                     /locus_tag="KR257_003538"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902783.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="histidine phosphatase family protein"
                     /protein_id="HBH0032195.1"
                     /translation="MGNTFYIVRHGQTDWNILGKTQGHGNSDLTPQGIEQAKELSEDI
                     GKYSIDYIFSSDLGRAMQTAQILGDKLNIEVQKTEALREMGFGVWEGLLIKEIQKDYS
                     DIYATWRNEPHLVNIPEGETLKIIKERVDAFIKELNEKYDNKNIILVTHSITLRVMLL
                     SFLESGMENIYRIKQDNTALNIVEFKDYGPVIVKMNDTSHIKNHVKINNSALE"
     gene            2239..3492
                     /locus_tag="KR257_003539"
     CDS             2239..3492
                     /locus_tag="KR257_003539"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003439456.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NAD(P)/FAD-dependent oxidoreductase"
                     /protein_id="HBH0032196.1"
                     /translation="MSKVIVVGGGASGMMAALSASKNNNEVILVERNGELGRKLRATG
                     GGRCNFTNNREIEDFFDKVVSNKKFLYSSFYTFTNKDLISYFESRNLEYKIEEENDHK
                     VYTKNDKSIEVIEVLNKDLLNHNVKIMYNKKVIDIITEEIALKDDSNKDKSKYLIKGI
                     ILDNGDKILGDKVIISTGGVSYSKTGSDGSMYKILKKHGHTLNKLYPALVPLTIEEKW
                     IKDLQGISMKNVEISCKIKKRKISKSGDMLFAHFGITGPCVLIMSSYINKIIEKEKVE
                     LNIDFLPNLSTDEISSIIRAFPNKNVLNNLKQILPQNFLKEIFSLLSLVDKKASDLSK
                     ADEIRIIEYIKNMKLTCNGTTGINTGMVTSGGISVKEINSSTMESKLVKNLFFTGEVI
                     DIDAETGGYNLQIAFSTGYLAGISV"
     gene            3538..4188
                     /locus_tag="KR257_003540"
     CDS             3538..4188
                     /locus_tag="KR257_003540"
                     /EC_number="2.7.4.25"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728624.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="(d)CMP kinase"
                     /protein_id="HBH0032197.1"
                     /translation="MGNLVIAVDGPAGAGKSTIAKIVAKKLNINYIDTGAMYRAVTYK
                     CLKSGIDVNNEKEVIQIAENSDIDFKDNNIYLDKEVINEEIRTIEVSNNVSNVAKIKE
                     VRQLMVEVQRKIGMKNSVILDGRDIGSYVFPDADYKFFLVATPEERGNRRYKELCNKG
                     YNTTLEEVIEDIIRRDEIDSNREFAPLVKANDALEIDTTGKTIEEVVEEVVSKINL"
     gene            4239..4835
                     /locus_tag="KR257_003541"
     CDS             4239..4835
                     /locus_tag="KR257_003541"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423868.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="1-acyl-sn-glycerol-3-phosphate acyltransferase"
                     /protein_id="HBH0032198.1"
                     /translation="MNFYRFVINIFKGFSKIFFKYEVIGAENIPDRGNIVIASNHKSN
                     LDPIFLAAAIENREIAAIAKKELFKVKPLGFILKKLHVMPINREKPDVSTIKTILRSV
                     RDGYVLGIFPEGTRIKGDSFGKAKAGLSVFTIKSKSKVVPVSIISKYKLFSKVIVYIG
                     EPISFEEHFKEKLSNDDHERISQEILEVIKQNYFKYSK"
     gene            4848..5687
                     /locus_tag="KR257_003542"
     CDS             4848..5687
                     /locus_tag="KR257_003542"
                     /EC_number="1.17.7.4"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893304.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="4-hydroxy-3-methylbut-2-enyl diphosphate
                     reductase"
                     /protein_id="HBH0032199.1"
                     /translation="MNIKIAKNAGFCFGVKRAMKMAWDEVEKNDSGIYALGPLIHNKQ
                     AVAKYEEKGLKTVNEIDTIPNHENMIIRSHGVPENIYKEAKDKKLKIVDTTCPFVKKI
                     HTVVSEYHNKGYEIIVIGDMKHPEVIGINGWCENSAIIIKTLEQMENMEFDNSKRYCL
                     VAQTTINPELYISIVNKLSDKLEEIVFNDTICSATKTRQESAKELAKKVDCMIVIGGK
                     HSSNTQKLVKVCEDLVPTFAIETKDELDVNTLKKYKNLGITAGASTPNWIIEEVVTFL
                     ENL"
     gene            5932..7086
                     /locus_tag="KR257_003543"
     CDS             5932..7086
                     /locus_tag="KR257_003543"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897020.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="arsenic efflux protein"
                     /protein_id="HBH0032200.1"
                     /translation="MEMLISASEEAFLHVGSMIGFFILLFGYINYKTSGNFTNIISKN
                     RKFQPLIGALIGAIPGCGGSLAIMPLYINGKLSFGAIIASLIASMGDAAFVLISSNIK
                     MYFFVTIVSTITGIITGQLVDYFKLEEKLGLKNRRKSDKYDISKNNPKENKEQHNHDE
                     IILDTLAKSHGNTNRLAFIITHGKGYKIYIGIIVIGFIFMSLAHSGLNLPIIEKLHSL
                     EEVIAVIGILFSIIYMWCFKKVFKNSNQKEEENKKISLREMLIHSVGEISFVITWIFI
                     AYLIYDLIILILGGDEYLVKLVLSTGVISVFIGAGLGLIPGCGIQIVLMSFYLKGTIP
                     LGAVIANSISQDGDALFPLLAMDKKSSLWAMIITTIPAILVGMIVYAFLG"
     gene            7392..7568
                     /locus_tag="KR257_003544"
                     /pseudo
     CDS             7392..7568
                     /locus_tag="KR257_003544"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728625.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="adenine deaminase"
BASE COUNT         3366 a          780 c         1391 g         2590 t
ORIGIN      
        1 caaatttatt gtcatttttt gtactttatg attatattat taatcttgta aaaatctctc
       61 ctgaaagaag aactgctttt ttagtaatag ttttactatt aatattatct aacatttcaa
      121 tctttgtatt aatacatata atacttaaga ttaaaattag gaaaataaga taaattttaa
      181 tacgattcat ttaaattaaa agttaataat tactttttta tgtataattt tacatgaatt
      241 tctataaaag ttattttatt aaagatagat atacttatat atacggatat aattaaaaaa
      301 agtcttttta actttaaaaa ttaatgttaa aaaataaact tatacattaa tattaataat
      361 aattatttaa atatcttaag taaatcagtc ttacatatat ttccgataga ttatattgat
      421 aaaaaacact aaaattaaat taataaaagt acttggaggg atggaaatga aagaggaaaa
      481 ttttattaat gttgaatacg aggataaacg tttttcaatt aatagtaaag aagttttgta
      541 catagaaaag caagagtatg aagtaaagat ttatactgaa agtggtaatt atgaagttgg
      601 agaaaatgct ccttgtataa gaaaactatt gaaagaagaa aattttttca aatgcagtaa
      661 tagttatatt gtaaatctag acaagtgtga attttatctc agcaataatt gtatttttgt
      721 gaataataat tttataagaa ttttaggttc agaaagaaaa aagaaattaa aaaagaaatt
      781 agaaaaatta tatgattatg aagattaata ttgggaggct gtattttata cagcctcttt
      841 atttattgat tgtattatta ataaatttta aattatgata aaatataaaa caagtaactt
      901 atttcagaat aaaatacttt ttaaaagaaa gggacgagat atgggagatt ataataaaat
      961 gcttgaatta aagaataact taggtatcag tgaaagaaag ttaaaatatc cttgtatcta
     1021 taaacatttc aaagggaaat attatgctac aatgggtctt agcaaggcta ttgatcatat
     1081 agaaaacata tgtgaaatat atggtaaaga aaatttaatc caaaacagaa ataaatataa
     1141 attagttatt agacatactg aaagagaaga agatatctat gtttataggg atttagatgg
     1201 aaacttttat cataaaaaag aagaagatac taatgattta gttttataca agaccttata
     1261 tgatgataca ggaatatttg caagaccttt ggatatgttt ttagaaaaag tagatacaga
     1321 taagtatgtc aattcaattc aagaatacag atttgaagaa gtatataaat aatataagag
     1381 aaatatgttt ataaatttag aaaaattctt taacagtaca ataatttgca gaaatacaaa
     1441 tgagatttat tgtaaataat atgttagatt agattataaa atagaaacaa agtaaagtat
     1501 tatatgatat aattaagttt tgagaagtga taatttatat ttaataaaaa ataggcatat
     1561 attaggagga catatgggaa atacttttta tatagtaaga catggacaaa cggattggaa
     1621 tatattggga aaaacacaag gtcatggtaa ttctgacctt acgcctcaag gtatagaaca
     1681 ggcaaaagaa ctttctgaag atattggcaa gtattcaatt gattatattt ttagtagcga
     1741 ccttgggaga gcaatgcaaa cagctcaaat tttaggagat aagctcaata ttgaagttca
     1801 aaaaactgag gcacttagag aaatgggatt cggagtttgg gaaggccttt taataaaaga
     1861 aattcaaaaa gattattcag atatatatgc aacatggaga aatgaaccac acttagtaaa
     1921 tataccagaa ggcgaaactc ttaagattat aaaggaaaga gtagatgctt ttataaagga
     1981 actaaatgaa aaatatgata ataaaaatat aattcttgtt acacattcaa ttacattgag
     2041 ggttatgttg ttgtcatttt tagaatcagg tatggaaaat atatatagaa ttaagcaaga
     2101 taatactgct ttaaatatag tagaatttaa agattatggg cctgttatag taaaaatgaa
     2161 tgatacaagt catataaaaa atcatgtaaa gataaataat tctgcactgg agtaggaatc
     2221 aattataagg agaaatttat gagtaaagtt atagtagttg gtggaggagc ttctggaatg
     2281 atggcagctt tgtcagcttc aaaaaacaat aatgaagtaa tattagttga gagaaatgga
     2341 gaattaggaa gaaaacttag ggcaactggt ggcggtagat gcaattttac caataataga
     2401 gagatagaag atttttttga taaagttgtc agtaataaaa aatttctcta tagtagtttc
     2461 tatacattta caaataaaga ccttatttcg tattttgaaa gtagaaattt ggaatataag
     2521 attgaagaag aaaatgacca caaagtatac actaaaaatg ataaatctat agaagtaata
     2581 gaagtattaa ataaagattt actcaatcac aatgtaaaga taatgtataa taagaaagtt
     2641 atagatatta taactgaaga aattgctcta aaagatgatt ctaataagga caagtcaaag
     2701 tatctaataa aagggattat tttagataat ggagataaaa tactaggaga caaggttatt
     2761 atatcaactg gaggagtgag ttattcaaag acgggttcag atggttcaat gtataagatt
     2821 cttaaaaagc atggacatac attaaacaaa ctatatcctg ctttagttcc acttacaata
     2881 gaggaaaaat ggattaaaga tttacaagga atatccatga agaatgtgga aatatcttgt
     2941 aagattaaga aaaggaaaat atcaaaatct ggagacatgc tatttgccca ttttgggata
     3001 acaggacctt gtgttcttat aatgtcttct tatattaaca agattattga aaaggaaaag
     3061 gtagaattaa atatagattt cttaccaaat ttaagtactg atgaaatctc tagtataatc
     3121 agagcatttc caaataaaaa tgttctaaat aatcttaagc aaatactacc tcaaaatttc
     3181 ttaaaagaga ttttttctct attatcttta gttgataaaa aggcaagtga tttgtctaag
     3241 gcagatgaaa ttagaattat tgagtatata aaaaatatga agctaacttg taatgggact
     3301 acaggtataa acactggtat ggttacttct ggtggtattt cagttaaaga aattaattct
     3361 tctactatgg aatctaaatt agttaagaac ttatttttta caggtgaagt aattgatata
     3421 gatgcagaaa ctggtggata taatttacaa atagcatttt caactggata tcttgcgggt
     3481 ataagtgtat aaatataatt ttttaataat taaatatgaa taaatagagg tgtatatatg
     3541 ggtaatttag ttatagctgt agatggtcca gcaggagctg gaaaaagtac aatagccaag
     3601 atagtagcaa aaaagctaaa tataaattat atagatacag gtgctatgta cagagcagtt
     3661 acttataagt gtttaaaaag tggtattgat gtcaataatg aaaaagaagt tattcaaata
     3721 gctgaaaatt cggatataga ttttaaagat aacaatatat atttggacaa agaagttata
     3781 aatgaagaaa taagaacaat agaagtaagc aataatgttt ctaatgtagc aaaaataaaa
     3841 gaagtaagac agttgatggt tgaagttcaa cgaaaaatag gaatgaaaaa ttcagtaata
     3901 ctagatggta gagatatagg ttcatatgtt ttcccagatg cagattacaa attcttttta
     3961 gtagctactc cagaagaaag aggaaataga cgctataaag aactttgtaa taaaggatat
     4021 aatactactt tagaagaagt aattgaggat ataataagac gagatgaaat tgattcaaat
     4081 agagaatttg caccattggt aaaagctaat gatgcactag aaatagatac tacaggaaaa
     4141 actatagaag aagttgtaga agaagttgta tctaaaataa atctttagtt ttttatgcat
     4201 cataatgaaa ataaatgtag tgttgaaggg agataaacgt gaatttttat agatttgtaa
     4261 taaatatttt taagggtttt tctaaaatat tttttaaata tgaagttata ggtgcagaga
     4321 atattccaga tagaggaaat atagtaatag catcaaatca taaatcgaat cttgacccta
     4381 tattcttggc tgctgccata gaaaatagag aaatagctgc aattgcaaag aaagaattgt
     4441 ttaaagtaaa accattggga tttatattaa aaaaattgca tgttatgcct ataaatagag
     4501 aaaaaccaga tgtatctaca ataaaaacta ttttaaggtc agttagagac ggttatgtat
     4561 taggaatatt tccagagggt actagaataa aaggagattc ttttggtaag gctaaggcag
     4621 gtctttctgt atttacaata aaaagtaaat ctaaagttgt tccagtatca ataatatcta
     4681 aatataaact ttttagtaaa gtaattgtat atattggaga accaatatca tttgaagaac
     4741 attttaagga aaaattgagt aatgatgacc atgaaaggat atcacaagag attttagaag
     4801 tgataaaaca aaattacttt aaatattcaa aataaggggg taaagttatg aacataaaaa
     4861 tagcaaaaaa tgctggcttt tgttttggag taaaaagagc aatgaaaatg gcatgggatg
     4921 aagttgaaaa aaatgattct ggcatatatg ctttaggtcc tcttattcat aacaagcaag
     4981 cagtagcaaa atatgaagaa aaaggtctta agactgtgaa tgaaattgat acaataccaa
     5041 atcatgaaaa tatgataata aggtctcatg gagttcctga aaatatatat aaggaagcca
     5101 aagataaaaa attaaaaatt gtggatacta catgtccatt tgtaaagaaa atacatacag
     5161 tagtaagtga atatcataat aaaggctatg aaataatagt tattggagat atgaagcatc
     5221 cagaagttat aggtataaat ggatggtgtg aaaattcagc tataataata aagaccttag
     5281 aacaaatgga aaatatggaa tttgataact ccaaaagata ttgtcttgtt gcacagacta
     5341 caataaatcc agagttgtat ataagtatag ttaataaact atcagataaa ttagaagaaa
     5401 tagtatttaa tgatacaatt tgttcagcta caaaaacaag acaagaatca gctaaagagt
     5461 tagctaaaaa agttgattgt atgatagtta taggaggtaa acacagttca aatactcaaa
     5521 agttagtaaa ggtttgtgaa gacttagtac caacttttgc aatagagact aaagatgaat
     5581 tggatgtaaa tacgcttaaa aaatataaaa atttgggtat tacagcaggg gcatctacac
     5641 ctaattggat aatagaagaa gttgtaacat tccttgaaaa tttataattt gataggtaat
     5701 aaaaataggt ggacattgtt ataatttatc ataatatcca cctttgattt catattacat
     5761 gtggtaaata gataacctaa tatcaaaaag tgtgtatctt aagatgaaaa actaagagta
     5821 taagatgcgc actttttaat attagaaatt caaaagaaat attgatattg attatcaata
     5881 gaaaatagaa tataatataa ttgttgcaaa attagtctag gaggtaaatt aatggaaatg
     5941 ttgatatccg cttctgaaga ggcgttttta catgtaggtt ctatgattgg attttttatt
     6001 ttgttatttg gatatattaa ttataaaact agtggaaatt ttactaatat catatcaaaa
     6061 aacagaaaat ttcaaccctt aataggtgct ttaattggag ctataccagg ttgtggcgga
     6121 agtttggcaa taatgccatt gtatataaat ggaaaattaa gctttggagc aataattgca
     6181 agtttaatag ctagtatggg agatgcagca tttgtactta tttcatcaaa tattaaaatg
     6241 tatttttttg tcactatagt tagtacaatt acaggaataa taactggaca attagtggat
     6301 tactttaaac tagaagaaaa attagggtta aaaaaccgta gaaaatcaga taaatatgat
     6361 ataagtaaaa ataaccctaa agaaaataaa gaacaacata atcatgatga aataatttta
     6421 gacactctag ctaaatctca tggaaataca aatagacttg catttataat aacacatgga
     6481 aagggatata aaatttatat aggaattata gtaatcggtt ttatatttat gtcacttgct
     6541 cactctggac ttaatcttcc tataattgag aagttacatt cattggaaga agtaatagca
     6601 gtgattggaa tattattttc aataatttat atgtggtgtt ttaaaaaggt atttaaaaat
     6661 tctaatcaaa aagaggaaga aaataaaaag atttctttgc gagaaatgct tatccattct
     6721 gttggagaaa tatcatttgt aattacatgg atttttattg catatcttat ttacgatttg
     6781 ataatattaa ttttaggtgg agatgaatac ttagttaaat tagtattatc aacaggtgta
     6841 ataagtgtat ttataggtgc aggtcttgga cttattccag gttgtgggat acaaattgtg
     6901 cttatgtcat tttatttgaa gggaactata ccacttggtg cagtgatagc caactctatt
     6961 tctcaagatg gagatgcact tttcccactt ttagcaatgg ataaaaaatc ttctttatgg
     7021 gctatgatta ttactactat accagcaata cttgtaggta tgatagttta tgcattttta
     7081 ggttaaatat aattatgaat aaagaagtat taaaaaaata ataaagcaca taaatttatt
     7141 tataagaata gtgaagatta aatataaaaa taaaaaattc aatatgaatt aaattattgc
     7201 ttaaatatta atgagaacat gggagataat attattcctc atgttctctc tatttaatta
     7261 aaggaattat ggaacaaatt tcaagtgata ctttctatca aaactcatat ataatatata
     7321 ttaataaatt aaactataat acgtaataca gtcagtatat tgatataaaa aacttaggag
     7381 gagttgtaaa aatgggtaat ttaaaaagac agtgtgatgt ttcaagtgga agagaaaaag
     7441 ctgacattgt actaaaaaat gggacaatca taaatgtatt tacagaagag ttaataacag
     7501 gagatgtagc aatagtagga gacactatcg ttggaattgg cgattacaag ggcaatgtag
     7561 aaattgatta aaaaatagct acgcacactc gtgactttag tcatgagtta gtagctaaaa
     7621 tagtcagcat atagggaaac ctatatgtag agataggata gaacctatcc aatactactt
     7681 gaattgctgg aaacccctaa agctaatcaa actaaaacat aaggatgaaa taaacctaag
     7741 tgtgaaagtt acgaaagtag aaaaaattgg ttagatggta taaggttaaa ccctaagtac
     7801 tttaaaatgg gcaatcagca ggtaaactcc gaataggaga aacttcaacg actattcctc
     7861 ttgagggaag tacactacaa gctattggta gtggaagtgg gtagacctta acggataatg
     7921 ctgaaggata agatatagtc tgtgcttgca tgaaagtgta agaagttcat aagagaactg
     7981 cataggtagt agcgaactta tgtgaacgac aacctcaaaa atgataaaag ttaagactta
     8041 cggttcttaa atatgttatt taaaattaaa tataaaacct tctaaataat tgttttaaat
     8101 aattacattt gttaacatta ttatagg
//
LOCUS       DAEPID010000124         7847 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.125, whole genome shotgun sequence.
ACCESSION   DAEPID010000124 DAEPID010000000
VERSION     DAEPID010000124.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 7847)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7847)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..7847
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.125"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     regulatory      120..224
                     /regulatory_class="riboswitch"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00504"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="glycine riboswitch; Derived by automated
                     computational analysis using gene prediction method:
                     cmsearch."
                     /bound_moiety="glycine"
                     /db_xref="RFAM:RF00504"
     gene            434..2908
                     /gene="gcvPA"
                     /locus_tag="KR257_003545"
     CDS             434..2908
                     /gene="gcvPA"
                     /locus_tag="KR257_003545"
                     /EC_number="1.4.4.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420319.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aminomethyl-transferring glycine dehydrogenase
                     subunit GcvPA"
                     /protein_id="HBH0032201.1"
                     /translation="MNELKRVSLYNIHKELGAKLVEFAGWEMPLEYEGINKEHEKVRK
                     SAGIFDVSHMGEVQIKGAESEKFIQNLVTNDISALKINDIIYTPMCYENGGVVDDLLI
                     YKFGEEDYLLVINAGNIDKDVAWIIKQSEGYNVDIKNISSEVSQLAIQGPKAEEILQK
                     ITDIDLNSIKFYKSIPSTKVCGCPCLVSRTGYTGEDGFEIYCKNKYVEIIWNEVLKVG
                     GEDICPAGLGCRDTLRFEAALPLYGHEINEHISPIEGGLSIFVKTNKESFIGKSILSK
                     EKESGAKRKLVGFEMQGKGMPRNGYDIRIGDKTVGFVTTGCASPTTGKILGMGIIDSE
                     YAKVGNEIGIAIRKKVVPAVIVKKPFYKKQYKKDNIILNKENKFSYIPATSEDKSKML
                     KVVGLNSVDELFSDIPEEVKLKRDLNLEIGKSELEVSKIVKRLSEENLSLEDLTCFLG
                     AGAYDHYIPSIIKHITSRSEFYTAYTPYQAEISQGTLQVVFEFQSMIAEITGMEIANA
                     SMYDGATAAIEACIMAMNQTRKSKIVVSKTIHPETLSILRTYLQYKDCEIVEIDFCNE
                     YGTTDIEKLKASVDKDTACVLIQTPNFFGIIEEMEEIEKITHENKAMLIMSVDPISLG
                     VLKTPGEIGADIVVGEAQSLGNPLNFGGPYVGFLASKSKYTRKMPGRIVGQSLDVEGK
                     IAYVLTLQTREQHVRREKATSNICSNQALNALVASIYIATMGKEGFKEVGMQSMKKAH
                     YTYNKLVQTGKYKPIFKGKFFKEFAVQGNLNIETINDKLLEENILGGYNLEYNYPELK
                     NSTLLCVTEKRSKEEIDKLVGIMEGL"
     gene            2908..4365
                     /gene="gcvPB"
                     /locus_tag="KR257_003546"
     CDS             2908..4365
                     /gene="gcvPB"
                     /locus_tag="KR257_003546"
                     /EC_number="1.4.4.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861288.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aminomethyl-transferring glycine dehydrogenase
                     subunit GcvPB"
                     /protein_id="HBH0032202.1"
                     /translation="MKEYNSLLIDISKKGRKAYSLPKLDIDDIKIENMIDQDMARQSE
                     LNLPEVGELELVRHYTLLSNKNFGVDTGFYPLGSCTMKYNPKINEDMAALPNFTGMHP
                     YQSSDTAQGSLSLMYDLSRRLAEITGMDEVTLQPSAGSHGEFTGLMIIKAYHENRGDH
                     KRTKVIIPDSAHGTNPASAAMANFDVIQIASDKNGAVDINALKEVLNDEVAALMLTNP
                     STLGLFEKNIKEIATLVHEAGGLLYYDGANMNAIMGITRPGDMGFDVVHLNLHKTFST
                     PHGGGGPGAGPVGVKKELVPFLPIPVIERKEDKYVLNYDREKSIGKIKNFYGNFGVLV
                     RAYTYILTMGRDGLKEASEMAVLNANYIKESIKDDYILPIDTLCKHEFVLGGLPRGEA
                     NIKTIDIAKRLLDYGYHPPTMYFPLIINEALMIEPTESESIETLDSFIEAMKSVAKEA
                     KEEPELLKTAPHNTLVKRVDDARAVKKPILTWSQR"
     gene            4788..7145
                     /locus_tag="KR257_003547"
     CDS             4788..7145
                     /locus_tag="KR257_003547"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893215.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HAD-IC family P-type ATPase"
                     /protein_id="HBH0032203.1"
                     /translation="MDKVNLERYSCDINVGLNKNQLQSRIDDNLINAFDNGKTKTYKQ
                     IFKDNIFTLFNLINIVLVCLLVSVGSFKNTLFIFIAVINTIIGVIQEIRAKRLLDNLS
                     VIVSNKVSVIREKEKKEIDVQELVLDDIMILKTGNQICADSKVLNGKLEVNESLVTGE
                     SDIIIKNKGDFLYSGSFVVSGEAFVRVENIGKDNYANKIANDAKISKKHNSQLRNSLN
                     AILKIVGIIIIPLGIILFAKQHFGNGDSIATSVVGTVAAVNGMIPEGLTLLTSIALAV
                     GTIKLASHKTLVQELYCVETLARVDTLCLDKTGTITEGKMQVDDIVMLEEVDINEIMG
                     NICNSLKDDNATLNAIRDKYNVLDTYKAKNLIPFSSERKYSGVTFENKGTYLLGAFEF
                     IFKEKNKKLRIEVERYSKKGNRVIVLAHSDSYMEDNNIPEDIKPLAFILILDKIRDEA
                     KETLEFFYNEGVDIKIISGDNPITVSEVARKAGLKTASNFIDATTLKNDSDIYKAVDK
                     YSVFGRVSPQQKKQMILALKKQNHTVAMTGDGVNDVLALKEADCSIAMASGSDVTKNV
                     SNLVLLDSNFASMPKVVMEGRKVINNIQRASSLFLVKTIFSFFLSLLTLFFFSRQYPF
                     VPIQLSLIGAVTVGIPSFFLALEANKSRISGNFLLNILKNALPGALCVTVNVIIVYNI
                     VEYLGYSSSVFSTMCAILTGVCGLLILRQQCLPFNKERLFLIVSMTIAFVIGILFLGG
                     LFSFVALSRELILITMALAILMPIMIKVMLFVLDEILETIVPDLN"
     gene            complement(7231..7548)
                     /locus_tag="KR257_003548"
     CDS             complement(7231..7548)
                     /locus_tag="KR257_003548"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729474.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pyrimidine/purine nucleoside phosphorylase"
                     /protein_id="HBH0032204.1"
                     /translation="MSEFKNVTAVKKANVYFDGKVSSRVIILPNGERKTLGLMLPGEY
                     TFSTREEEIMEMLAGSMDVKLPGSNEFVTYKEGQKFNVPSDSSFDLKVNEVVDYCCSY
                     IAD"
BASE COUNT         3112 a          849 c         1380 g         2506 t
ORIGIN      
        1 gagaaataat tgataataaa aacttaacaa aaaaattaat acataaaaaa aaataaatat
       61 aatgtgttga catttaattg aaatattcat acaataaaat tgaaaataaa tatttccaaa
      121 tgagattagc gagagagtcc tttatacgaa aaggcgccga agaagaaatt taagaaatgc
      181 caatttttag agaagctttc aggcaaaaat atcgctaatt gatgggactc tggagagact
      241 taagttaaga tactataagt caccgaagaa gcaaaataat attaaattat taaatctttc
      301 aggtatacaa acagggatat ataggctagg attattttcc atgctgatat atcttttttt
      361 tatgaaaaag tacaggaaat aatatcaaag ttacttaaat acagtaggtc taattttcta
      421 gggagggtta tatatgaatg aattgaaaag agtatctttg tacaatatac acaaagagct
      481 tggagcaaaa cttgttgaat ttgctggttg ggaaatgcct ttagaatatg agggtataaa
      541 taaagagcat gagaaggtca gaaaaagtgc aggtatattt gatgtatctc atatgggaga
      601 ggtacagata aagggagcag agtcagaaaa atttatacaa aacctagtta caaatgatat
      661 aagcgcatta aagataaatg atattatata tacacctatg tgttatgaaa atggtggagt
      721 agttgatgat ttattaatat ataaatttgg tgaagaagat tatttattag taataaatgc
      781 aggtaatata gataaagatg tagcatggat aataaaacaa agtgaaggat acaatgtaga
      841 tataaaaaat atatctagtg aagtgagtca attagcaatt caaggaccta aagcagaaga
      901 aattcttcaa aaaatcacag atatagactt aaactcaata aaattttata agtcaattcc
      961 atcaacaaaa gtatgtggtt gtccttgttt agtttcaaga acaggatata ctggggaaga
     1021 tgggtttgag atatactgta aaaataaata tgtagaaata atttggaatg aagttctaaa
     1081 ggttggagga gaagatatat gtccagctgg tctaggttgt agggatactt tgagatttga
     1141 agcagctcta cctctatatg gacatgaaat aaatgaacac atatctccaa ttgaaggtgg
     1201 tttatctatc tttgtgaaaa caaataaaga atcatttatt ggcaaatcaa ttttatcaaa
     1261 agaaaaagaa agtggagcta aaagaaagtt agtaggattt gaaatgcaag gtaaaggaat
     1321 gcctagaaat ggatatgata taaggattgg tgataaaaca gttggatttg taacaacagg
     1381 atgtgcatct ccaacgacag gaaaaatttt aggtatggga attatagatt ctgaatatgc
     1441 aaaagtagga aatgaaatag gtatagcaat cagaaaaaaa gttgttcctg ctgtgatagt
     1501 taagaaacct ttttataaaa aacaatataa aaaagataat attatattaa acaaagaaaa
     1561 taaattttca tatatacctg ctacaagtga agataaatca aaaatgttaa aagtagttgg
     1621 attaaattcg gttgatgaat tattttcaga tataccagaa gaagtaaaat taaaaagaga
     1681 tttaaatttg gaaattggaa aatctgaatt agaggtaagc aaaatagtaa aaagattgtc
     1741 agaagaaaat ttaagtttag aagacttgac ttgttttctt ggtgctggtg catatgacca
     1801 ttatatacca tcaattataa aacatataac ttcaagatct gaattttata cagcatatac
     1861 tccatatcaa gctgaaataa gtcagggaac tttacaagta gtttttgaat ttcaatctat
     1921 gattgcagaa attacaggta tggaaattgc aaatgcatca atgtatgatg gagcaactgc
     1981 tgcaatagaa gcatgtataa tggcaatgaa tcagactaga aaaagtaaaa tagtagtgtc
     2041 aaaaactatt catcctgaaa ctttgtcaat attaagaact tacttacaat ataaagattg
     2101 tgagatagta gaaattgact tttgtaatga atatggcact acagatatag aaaaattaaa
     2161 agcttctgta gacaaagata cagcatgtgt tcttatacaa actcctaatt tctttggaat
     2221 tattgaagaa atggaagaaa tagaaaagat aactcatgaa aataaggcta tgttaattat
     2281 gagtgtagac ccaatatcat taggagtttt aaaaacacca ggtgagatag gtgcagatat
     2341 tgttgttgga gaagctcaat cacttggaaa ccctcttaat tttggaggtc cttatgtagg
     2401 atttttagct agcaaatcta aatatactag aaaaatgcca ggaagaatag ttgggcaaag
     2461 tttagatgta gaaggtaaaa ttgcatatgt attaacttta caaactagag aacagcatgt
     2521 aagaagagaa aaagcaactt ctaatatatg ttcaaatcaa gctttaaatg ctcttgtagc
     2581 ttcaatatat atagctacta tgggtaaaga aggatttaaa gaggttggta tgcagtctat
     2641 gaaaaaagca cattatactt acaataagct tgtacaaact ggaaaatata agccaatatt
     2701 taaaggtaag tttttcaaag aatttgctgt acaaggaaat cttaatatag aaactataaa
     2761 tgataaactc ttagaagaaa atatattagg tggttataat ttagaataca attatccaga
     2821 attaaaaaat tcaactttgc tttgtgtgac tgagaaaaga agcaaagagg aaatagataa
     2881 gttagttgga ataatggagg gattataatg aaagaataca atagtttgtt gatagatata
     2941 tctaaaaaag gtaggaaagc atactcactt ccaaagttag atatagatga tataaaaata
     3001 gaaaatatga ttgaccaaga tatggcaaga caaagtgagt tgaatttgcc agaagttggt
     3061 gaattagaat tagttagaca ttatacatta ttatcaaata aaaactttgg agttgataca
     3121 ggtttttatc ctttgggttc ttgtactatg aaatataatc ctaaaataaa tgaagatatg
     3181 gcagcacttc caaactttac tggaatgcat ccataccaat cttcggatac agctcaaggt
     3241 tctctttctt tgatgtatga tttatcaaga agacttgcag aaattacagg tatggatgaa
     3301 gttacactac aaccttcagc aggttctcat ggtgagttta cagggcttat gattataaaa
     3361 gcatatcatg aaaatagagg tgaccataag agaaccaaag tgataattcc agattctgca
     3421 catggaacaa atccagcaag tgcagctatg gcaaactttg atgtgattca aatagcatct
     3481 gataaaaatg gagctgtaga cataaatgca ttaaaagagg ttttgaatga tgaagtagca
     3541 gctcttatgc ttactaatcc aagtactctt ggtttatttg aaaaaaatat aaaagaaata
     3601 gctactcttg tacatgaagc aggaggactt ttgtactatg atggtgcaaa catgaacgct
     3661 attatgggga taacaagacc tggagatatg gggtttgatg tggttcatct taatcttcat
     3721 aagacttttt caactcctca tggaggtgga ggtccaggag ctggtcctgt tggagttaaa
     3781 aaagaattag tacctttttt accaatacca gtaattgaaa gaaaagaaga taagtatgta
     3841 ctaaattatg atagagaaaa atctattggg aaaattaaaa atttctatgg taattttgga
     3901 gttcttgtaa gagcttacac atatatacta actatgggaa gggatggact taaagaggct
     3961 agtgaaatgg cagttttaaa tgctaattat ataaaggaaa gtataaaaga tgattatatt
     4021 ttgccaatag ataccttgtg taagcatgag tttgtattag gtggattgcc aagaggagag
     4081 gccaatataa aaactatcga tattgcaaaa agactactag attatggata ccatcctcca
     4141 acaatgtact ttcctcttat tataaatgag gcacttatga tagaacctac agaaagtgag
     4201 agtatagaga cattagatag ttttatagaa gctatgaaaa gtgttgctaa agaggcaaag
     4261 gaagaaccag aactattgaa aactgctcca cataatactt tggtcaaaag agtagatgat
     4321 gcaagggcag taaagaaacc tatactaaca tggtcacaaa gataaatagt taaaaagtag
     4381 agatttaaag tataaagaga attaaatttg taagaaaaag ctatctaact taatctagtt
     4441 tagatagctt ttttgtatat tagtatgtat ggtattttct atataaagtt ttaaattata
     4501 ttagtgctta tatagaatat tgatatgatg attatgtata gatattaata agaattgttg
     4561 aatttatctt gccttaactt tatttactct tttatattaa gaaaaactta actaaaatat
     4621 agcgaaattc ataaaaattt aggaaatctt aagaattata atatttaaat ctttagattt
     4681 atattttatt atataaacta tagaataata aaataaaaaa attgagaatt ttataatata
     4741 tttgtagatt tgagtataaa aaagtgctaa gttgaaagga gtaaaatatg gataaggtta
     4801 atttagaaag gtatagttgt gatataaatg ttggtttaaa taaaaatcaa cttcaaagta
     4861 gaatagatga taatttaatt aatgcatttg ataatggaaa aaccaaaaca tataaacaaa
     4921 tttttaaaga caatatattt acacttttta atctcataaa tattgtttta gtctgtttat
     4981 tagtttcagt tggttctttt aaaaatacct tatttatatt tattgctgta attaatacta
     5041 ttataggagt aatacaagag ataagagcta aaagattatt ggacaatcta tctgttatag
     5101 tttcaaataa ggtatctgtc ataagagaaa aagagaaaaa agagattgat gtacaagaat
     5161 tagtattaga tgatattatg attttaaaaa caggtaatca aatttgtgca gattcaaaag
     5221 ttttaaatgg aaaattagag gtaaatgagt ctttggttac aggtgaatct gatattatta
     5281 taaaaaataa aggcgatttt ttatattctg gaagttttgt agtttctgga gaagcttttg
     5341 taagagttga aaatatagga aaagataact atgcaaataa gatagctaat gatgcaaaga
     5401 tttctaaaaa acataattct caacttagaa attcattaaa tgcaatatta aaaattgtag
     5461 gtataataat aattccttta ggaattatat tgtttgcaaa acaacatttt ggaaatggag
     5521 attctatagc tacatctgta gtaggtacag tggcagctgt aaatggtatg ataccagagg
     5581 gattaacatt acttacgagc attgctctag ctgtaggaac tataaaactt gctagtcata
     5641 aaactttagt gcaagaactg tactgtgtag agactcttgc tagagttgat acactatgtc
     5701 ttgataagac aggtacaatt acagaaggta aaatgcaagt tgatgatata gtaatgttgg
     5761 aagaagtgga tattaatgaa ataatgggga atatatgtaa ttctctcaaa gatgataatg
     5821 caacactaaa tgcaataaga gataagtata atgttttaga tacgtataaa gctaagaatt
     5881 taataccatt ttcttcagaa agaaaataca gtggggttac ctttgaaaat aaaggtacat
     5941 atttattagg tgcatttgag tttatattta aggaaaaaaa taaaaaactt aggatagaag
     6001 ttgaaagata ttctaaaaaa ggaaacagag taatagtttt agctcatagt gattcttata
     6061 tggaagataa taatattcct gaagatataa agccactagc ttttatattg atattggata
     6121 aaattagaga tgaagctaag gaaactttag aattttttta caatgaaggt gtagatataa
     6181 aaattatatc tggtgacaat cctataacag taagtgaggt agctagaaaa gcaggtctta
     6241 aaacagctag taattttatt gatgcaacaa cacttaaaaa tgatagtgat atatacaaag
     6301 cagttgataa atacagtgtt tttggaaggg taagcccaca acagaaaaaa caaatgattt
     6361 tagcattaaa aaaacaaaat catacagtag ctatgactgg agatggtgta aatgatgtac
     6421 tagcacttaa agaagcggat tgtagcattg ccatggcatc tggaagtgat gttactaaga
     6481 atgtgtctaa tttagtctta ttagattcaa actttgcatc aatgccaaag gttgttatgg
     6541 agggaagaaa agtaattaat aacattcaaa gagcatcttc tttgttttta gtaaagacaa
     6601 ttttttcatt cttcttgtcg ttattaacat tattcttctt cagtagacag tatccatttg
     6661 ttcctataca attatcactc attggggctg taacagtggg tataccatca ttcttcttag
     6721 ctcttgaagc aaacaaaagt agaatttcag gaaatttttt actcaatata ttaaaaaatg
     6781 ctttaccagg agcactatgt gtgacagtaa atgtaattat tgtttacaat atagttgaat
     6841 atttaggtta tagttcaagt gtattttcca caatgtgtgc tatattaact ggtgtatgtg
     6901 gtcttttaat attgagacaa caatgtttgc catttaataa agaaagatta tttttaatag
     6961 taagtatgac tattgcattt gttattggga ttctattttt aggtggatta ttctcatttg
     7021 tagcattgag tagagaatta attctcataa ctatggcatt agcaatatta atgccaatta
     7081 tgataaaagt tatgttattt gtcttagatg agatattaga gacaattgtt ccagatttaa
     7141 attaatttta aaatgatata aataagagca gttttagttg aactgctctt tttagatgtg
     7201 tttaatttta tgtaagaata tgtattttta ttaatcagct atatatgagc aacagtagtc
     7261 aacaacttca ttaaccttta agtcaaaact tgaatcacta ggaacattaa atttttgccc
     7321 ttctttataa gttacaaact cattgcttcc aggcagtttt acatccatac ttccagcaag
     7381 catctccatt atttcttctt ctctagtaga aaaagtgtat tctcctggca acattaatcc
     7441 taaagttttt ctttctccat taggcagtat tattactctg ctacttacct taccatcaaa
     7501 ataaacgttt gccttcttta ctgcagtaac attcttaaat tcactcatta gataaaacct
     7561 ccaaaattat ttgtacatat atattatata aaaataatgt aaaaaatgct atatatttac
     7621 aaaaaaattt agtatttatt aaaaaaatta ataagaataa aaaagaggtg aaattgctta
     7681 aattgataaa aaatataaaa taaattgcaa agtaagcaag aaaagaataa gttgaagagt
     7741 tatatattat aaatattaaa aattttagta ttaataaaaa agatattaca ttaatatgaa
     7801 aatataggag attagaagtg tttgattaaa aaatagctac acacact
//
LOCUS       DAEPID010000125         7812 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.126, whole genome shotgun sequence.
ACCESSION   DAEPID010000125 DAEPID010000000
VERSION     DAEPID010000125.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 7812)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7812)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..7812
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.126"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            315..1616
                     /locus_tag="KR257_003549"
     CDS             315..1616
                     /locus_tag="KR257_003549"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437698.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AAA family ATPase"
                     /protein_id="HBH0032205.1"
                     /translation="MGKSKDVEIEKSILGTILLDNKLSYKLDELNENMFMNDICLEIF
                     KIMKELKKENIVIDVATVKSKIDRKSLAIKTSDVTNLITWGQNFGLDGHIKILKENLA
                     RRSINQNCQNLLHSLNLGENIDTCIYKFESNIKEILDKDTYENDDVNSIAGKVLDFLE
                     NKKDIGFKFGIKLLDTTIGGLFKGELTTIAAKSGVGKTALALQIMLNSFKQGKKTLFI
                     SREMTSEQVFMRNICRVTGVSTRNMKSKEIDENDWKLIVNAIGDLSENNLIYINDKID
                     TISAIRKRIRQVKPDLLIVDYVQLLTSQKSMDKREREVATFSRELKNMTLDFNIPVIQ
                     LSQLNDEMKDSRPYGDRPMRDSKAIYHDSNNVVYIHQLKGSDYEEAVRDIGESEEAVR
                     ASEYRGIKMVDLIVAKCRDGQTRHKHFCYFGDKLHFQELNY"
     gene            1692..1967
                     /locus_tag="KR257_003550"
     CDS             1692..1967
                     /locus_tag="KR257_003550"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418102.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcriptional regulator"
                     /protein_id="HBH0032206.1"
                     /translation="MLELRKIIELLEEHKIEVSIPKELHKYSLLEYLELCQQSGGTYF
                     YIKTLEGALKEARNELMIKLFNGKNYMELARMFEMSVINVRHIVRKK"
     gene            3410..3640
                     /locus_tag="KR257_003551"
     CDS             3410..3640
                     /locus_tag="KR257_003551"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418105.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="4Fe-4S binding protein"
                     /protein_id="HBH0032207.1"
                     /translation="MSNKKKKYANILANECVACGSCIKACPRSAISVPCGISAKINRD
                     LCVGCGICEKICPASVIEIITILKEEEGKCHE"
     gene            3633..4214
                     /locus_tag="KR257_003552"
     CDS             3633..4214
                     /locus_tag="KR257_003552"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418106.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="4Fe-4S binding protein"
                     /protein_id="HBH0032208.1"
                     /translation="MNNKKHWYDYLWIFSSIYLILGFVNIIFAWIGLICFFVPLAISI
                     VKGNKAYCNKYCGRGQLFNLLGNKLKLSRNRDIPKFIRSKWFRYGFLTFFMVMFANML
                     FSTYLVFEGSRNFKEVVTLLWTIKMPWQWAYHGTLVSPWVVQFAFGFYSVMLTSTVLG
                     LITMILFKPRSWCVYCPMGTMTQMICKAKSKSI"
     gene            complement(4789..5466)
                     /locus_tag="KR257_003553"
     CDS             complement(4789..5466)
                     /locus_tag="KR257_003553"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895646.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Crp/Fnr family transcriptional regulator"
                     /protein_id="HBH0032209.1"
                     /translation="MISQNEIDILTHSLPFWDKLTDLQKELLISSANTSHYKKGNPVH
                     CGDSDCIGILIIKSGTVRTYILSDEGREVTLFRLDDGDVCILSASCILKTITFDVYVD
                     AETDCDIIQISSSVFAKLSTENIHAELFSYKLATERFSDVMWAMQQILFMSFDKRLAS
                     FLIDEIAKNGSSTINMTHEQIAKYMGSAREVVSRMLKYFAREGIVSLSRGGIKVLDKD
                     KLRSLTL"
     gene            complement(5655..7019)
                     /locus_tag="KR257_003554"
     CDS             complement(5655..7019)
                     /locus_tag="KR257_003554"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902041.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MATE family efflux transporter"
                     /protein_id="HBH0032210.1"
                     /translation="MKESNKRIELLGSAPISKALLSMGLPTMIGMMITALYNLVDAYF
                     VGGLGTSQMGAISVAFPLGQLVVGLGLLFGNGAASYIARLLGHGDNEKAGKVVSTSIY
                     SSIIVGTLVIIVIMIFLNPILKLLGATKSIMPYAISYASIYVVSSIFNIFNVTMTNIV
                     TSEGAAKTTMCAMLLGALLNMILDPIFIYTFGLGVRGASIATAISQIASTLVYVGYIL
                     SKKSIFSFRINECCFSKEIFSEILKIGIPTLIFQLLTSLAITLTNMEATKYGDSVIAG
                     MGAVTRITSLGSLVVFGFIKGFQPIAGYNFGSKNYDRLHIAIKTSILWTTIFCVVLGL
                     ILILFPKSIISQFTSGDILLIENGSKALRANGFSFMLFGFYTVYSTLFLALGKAKEGG
                     FLGMCRQGVCFIPIILIIPVFYGLNGILYAQPIADLMAAIIAGFMSIRLHKELNLLKI
                     NGMH"
     gene            7147..7668
                     /locus_tag="KR257_003555"
     CDS             7147..7668
                     /locus_tag="KR257_003555"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888420.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PadR family transcriptional regulator"
                     /protein_id="HBH0032211.1"
                     /translation="MATIDLIVLGIVKQQPKSAYDIQKAVEYRNISRWVKISTPSIYK
                     KVIQLEQKGYIESKTVKNGKMPEKAVYSLTELGETHFLDLMFDTSSKPINILLDFNAV
                     IVNLNSLTPEKQKLCLNNIEENVQELKKTIEENISIKTEVPDTAKAVLEQQLVLAQAL
                     ETWINSLKDNMGN"
BASE COUNT         3050 a          876 c         1350 g         2536 t
ORIGIN      
        1 gaattatatt gaacgatata ttaataattg gcagtaagtt atatcaaata agatattact
       61 atcaagtagt gaattatatt gaacaatata ttaataattg gtagtaaagt atatcaaata
      121 agatattgct attatgtagt aaattatata aaacaatgta tcagaataaa tagtatatta
      181 ataatttgta gtatatcatg acgaataata cagtcataac aaatagtgag tcataacaaa
      241 taatgtattt ataattgata atgtatttaa aaatcaaaat ataaaaactt ataaggaaag
      301 agagattaat ttatatgggt aaatcaaaag atgttgaaat agagaagtct attttaggca
      361 caattctttt agacaataaa ttaagctata agctagatga attaaatgaa aacatgttta
      421 tgaatgatat atgtcttgag atatttaaaa ttatgaaaga acttaaaaaa gaaaacatag
      481 tgattgatgt ggccactgtg aaatcaaaga tagatagaaa atctctagca ataaaaacga
      541 gtgatgtgac taatctaatt acttggggtc agaattttgg tcttgatggt catattaaaa
      601 ttttaaaaga aaatttagct agaagaagca taaatcaaaa ttgccaaaac cttttacaca
      661 gcctaaacct tggagaaaat atcgatactt gtatttacaa atttgaaagt aatataaagg
      721 agattttgga caaggatact tatgaaaatg atgatgtaaa tagtatagca gggaaggtgc
      781 ttgatttttt agaaaacaaa aaagatattg gatttaaatt tggtataaaa ttacttgata
      841 ccactatagg aggtcttttt aaaggagagc taaccacaat agcagctaaa tcgggggttg
      901 ggaagactgc tttggcactt caaataatgt taaattcatt taagcaaggt aaaaaaactt
      961 tatttataag tagagaaatg accagtgagc aagtatttat gagaaatata tgcagagtaa
     1021 ctggtgtaag tacaaggaat atgaaatcta aagaaataga tgaaaatgat tggaaactta
     1081 ttgtaaatgc tataggtgat ttaagcgaaa ataacttaat ttatattaat gataagatag
     1141 atacaattag tgcaattaga aagaggataa ggcaggtaaa gccagattta ttaatagtgg
     1201 attatgtgca actccttaca tctcagaaaa gcatggataa gagagaaagg gaggtagcta
     1261 ctttttcgag agaacttaaa aatatgactt tagattttaa tatacctgta atccaattaa
     1321 gtcagttaaa tgatgaaatg aaagattcaa gaccttatgg agatagacct atgagggata
     1381 gcaaagccat ctaccacgat agcaacaatg tggtttatat acatcaatta aaggggagtg
     1441 attatgaaga agcagtgaga gatattggag aaagtgagga ggcagttaga gcatcagaat
     1501 acaggggaat taagatggtt gatttaatag ttgcgaagtg tagagatgga cagactaggc
     1561 ataagcattt ttgttacttt ggggataagt tacattttca agaactaaat tattaggtca
     1621 ataaagtagt aataacaagc ttattaaaag tcgggaaata gcaaatagat tataaaatat
     1681 gaggtgaaaa tatgttggaa ttaagaaaaa ttatagaatt acttgaagaa cacaagatag
     1741 aagtaagtat tccaaaggag ttacataagt atagtttatt ggaatacctt gaattgtgtc
     1801 aacaaagtgg gggaacatat ttttatatta aaacactgga aggggcttta aaagaggcta
     1861 gaaatgagct tatgattaaa ttgtttaatg ggaaaaatta tatggaatta gcgaggatgt
     1921 ttgaaatgag tgttattaat gtcaggcata ttgttagaaa aaaatagata tttttggaga
     1981 atacaagtgt gatatacttc tgaaatagaa gttattatag ttgaaataaa attgtggtta
     2041 ataaattaaa gttgtgtata agtttaagat tatagaggag tataagtgtg attaacagca
     2101 tgattttgtg aataaaattg aggatatata tgagttaaat gtgtgattaa taaggtaagg
     2161 ttgtgtataa gattatgagt atttaaaagg aggggctata attaatagtg tagagttgtg
     2221 tgtttgctta agattatata ataatttaat agattaaact atactaataa ggtaaaatcg
     2281 tgtgtttagt taaagcttat tataaaatct tgatatgtga ttaatgatgc aatatgtgaa
     2341 taaagttaag attataatag atttaacctg tggctaatag aataaaattg tgaataaagt
     2401 taagattata ataggtttaa cctgtgatta atagagtaag agtgtaaata gagataaact
     2461 tcaatatgag cttaacctat gattaataga gtaagagtgt aaatagagat aaacttcaat
     2521 atgagcttaa cctatgatta atagagtaag agtgtaaata gagataaact tcaatatggg
     2581 tttaacttgt gattaataga gtagggtgta actaaagata aacttcaata tgagtttaac
     2641 ttgtgattaa tagagtaagg tgcaactaaa gataaacttc aatatgagct taacctatga
     2701 ttaatagagt aagaatgtaa atagagataa acttcaatat gggcttaact tgtggttaat
     2761 agagtaagag tgtaactaaa gataaacttc aatatgggtt taacttgtgg ttaatagagt
     2821 aagaatgtaa atagagataa acttcaatat gagcttaact tgtgattaat agagtaagag
     2881 tgtaaataga gataaacttc aatatgggat taacttgtga ttaatagagt aagagtgtaa
     2941 ctaaagataa acttcaatat gagcttaacc tatgattaat agagtaagaa tgtaaataga
     3001 gataaacttc aatatgggtt taacctgtgg ttaatagagt agggtgtaac taaagataaa
     3061 cttcaatatg agtttaactt gtggctaata gaataagatt gtgaataaag ttatagtttt
     3121 agatgggtat taacctgtta ctaatagaat atgattaggt gtaaaattat agagctgtat
     3181 aagaaaatat tatagatata ttaaatatta gataataaat atttatatag atacacaaaa
     3241 gaaaaggcga tatgaagcta aacttaatga cttcatatcg ttttttattt gaaactcctt
     3301 tgtatttaga gtgtgatttt taatattgag gttttatgtg attaagtcac agataaaaag
     3361 taagtatctt gatataattc ttatagatta ataatatagg gaggttatta tgtctaataa
     3421 aaaaaagaag tatgcaaata ttttagcaaa tgagtgcgtt gcttgtggta gctgtataaa
     3481 agcatgtcca agaagtgcta tctcagttcc atgtggcatt agtgcaaaaa ttaatagaga
     3541 tttatgtgtt ggatgtggga tttgtgaaaa gatatgtcca gcatctgtaa ttgagattat
     3601 aacaatatta aaagaggaag aaggtaagtg tcatgaataa taaaaaacat tggtatgact
     3661 atttatggat tttttcttca atatatttga tattgggatt tgtaaatatt attttcgctt
     3721 ggattgggct aatttgtttc tttgttccac tagctatttc tattgttaag ggaaataaag
     3781 cttactgtaa taagtattgt ggaagagggc aactgtttaa tttgcttgga aataaattga
     3841 agctgtcaag aaatagagat attcctaaat ttattagaag taagtggttt agatatgggt
     3901 ttttgacatt ttttatggta atgtttgcca atatgctttt ttcaacttat ttagtgtttg
     3961 aaggaagtag aaattttaaa gaagtagtga ctttgttgtg gactataaaa atgccttggc
     4021 aatgggcgta tcatggaact ttagtttcac cttgggtggt acagtttgca tttggttttt
     4081 atagtgttat gcttacatca actgttcttg gtttgattac tatgatattg tttaaacctc
     4141 gttcatggtg tgtttattgc cctatgggta ctatgactca gatgatatgt aaggcaaaga
     4201 gtaagtctat atagaaaggc tttatgtgat atttacagtt ttgttagaga tgagtagtag
     4261 gtttgaatat atatgacaaa tatatgagta taggggcata gatttagttt gtgtaaggta
     4321 aactgattta tgcttctttt ttatgtctta gattattggc taagtggaaa caatgaattt
     4381 agatattaag aattattcag ttatttgaag aaaatagaat aataattaac attatatgaa
     4441 tggatattca ttacatataa gccagttaat agcaagattt atttaatatg aaataggtca
     4501 agtatttaaa ctaaataagg tcatgacaat taatataagt atagatataa aaagattaga
     4561 agttataact tataaaaggt attctatata aatagtatgt ggaaaatagt caaattaact
     4621 tattagaaac aaaaaatata cataaaaaaa taaatgtaaa tatcaaataa gatactatat
     4681 aaaaatagat ataagtatct tttttattat tgaaattatg aaaatatatt tgatttcaca
     4741 caaaaaagag tgcctcatga actaaaaagt tcattttgag acacactttt acagtgtcaa
     4801 agaacgaagt ttatccttat ccaatacttt tataccacca cgagataaag acacaatacc
     4861 ttctctagca aaatatttca acattctcga tacaacttct ctggcactac ccatatactt
     4921 agcaatttgc tcatgagtca tatttatagt gctactgcca tttttagcta tctcatcaat
     4981 taaaaaagat gccaaacgct tatcaaaact cataaaaaga atttgttgca tagcccacat
     5041 aacatcagaa aaacgttcgg tagctaattt atatgaaaat aactctgcat gaatattttc
     5101 tgtagataat tttgcaaaaa cagaggaact aatctgtata atatcgcagt ccgtttcagc
     5161 atctacatag acatcaaaag ttattgtttt tagaatacag gaagctgata aaatacatac
     5221 atctccatca tcaagtcgga acagtgtaac ctctcgacct tcatctgaaa gtatgtatgt
     5281 acgtactgtt ccagacttta taatcaaaat accaatacag tcactatcac cacaatgtac
     5341 tggattccct tttttgtaat gcgaggtatt tgctgaagaa attaataatt ctttttgtaa
     5401 gtcagtaagt ttatcccaaa aaggcaagct atgtgtaagt atatcgattt cattttgtga
     5461 aatcatacaa tatctccttt cttaaattgt tataatccca tgatacaagt gaatagataa
     5521 attgacaagt agtttgttaa taggattatt tagtcagata gtaatagtat gatttatgta
     5581 gaaaaaatat gataatatat attcttgcta ttaatgagaa ggtaatatgt tttgatgata
     5641 gtaggtttgt ataactaatg cataccgttt atttttaaaa gattaagttc cttatgtaac
     5701 cttatagaca taaaaccagc aattatagca gccatcaaat cagctattgg ttgtgcatat
     5761 aagataccat ttaacccata gaatacagga ataatcaaaa ttatagggat aaaacagaca
     5821 ccttgtctac acatacctaa aaatccacct tcctttgctt ttcctagtgc gaggaataat
     5881 gtagaataca ctgtatagaa tccaaatagc ataaatgaaa acccatttgc cctaagagct
     5941 ttactaccat tttctattaa tagaatgtca ccacttgtaa attgtgaaat tatagatttt
     6001 gggaagagta tcaatataag accaagcact acacaaaata ttgtagtcca taatatggaa
     6061 gtttttattg ctatatgtaa tctatcgtag ttctttgaac caaaattata accagcaatt
     6121 ggttggaaac cttttataaa accaaataca acaagactac ctaaagacgt tattcgtgtt
     6181 acagcaccca ttccagctat cacagaatca ccatactttg tagcctccat attagttaat
     6241 gtaatggcaa gactagtcaa taattgaaat attaaggtag gtatgccaat ttttaggatt
     6301 tctgaaaaaa tttcttttga aaaacagcat tcgttaattc taaaactaaa tatacttttc
     6361 ttgcttaaaa tatatcctac ataaacaagt gttgaagcaa tctgtgagat agctgttgca
     6421 atagaagcac cccttacccc cagaccaaaa gtataaatga atattgggtc taaaatcata
     6481 ttaagcaaag cacctaataa catagcacac atagttgttt tagcagctcc ttcacttgtg
     6541 acaatattag tcatagtgac attgaatata ttaaaaatag atgacacgac ataaatgcta
     6601 gcataagata ttgcataagg cataatactt tttgtagctc ctaacaattt taaaattgga
     6661 ttgagaaaaa tcataatcac aataataact aatgtaccca ctataatact actgtaaata
     6721 gatgtactta ccacttttcc tgctttttca ttatcaccat ggcctaaaag tctggcaata
     6781 tatgaagcag ctccatttcc aaacaataat cctaatccca caacaagctg acctaatgga
     6841 aatgcaacgg atatagctcc catttgactt gttccaagtc cacccacaaa gtatgcatca
     6901 accaaattgt ataatgcagt tatcatcata cctatcatgg taggtaatcc catagataac
     6961 aatgcttttg agattggggc agaccctaat aattcaattc ttttgttact ttctttcata
     7021 cttaacactc ctcttctatt gacattaagt ctaaattata atactataaa ttatagtaag
     7081 tatggaaaat agtactataa tttatagtat ttgtcaatag taagaaaact aaaggagatg
     7141 atttttatgg ctacaataga tttaattgta ttgggaatag taaagcaaca acccaagagt
     7201 gcttatgata ttcaaaaggc agtggaatac aggaatatat cacgttgggt taaaataagt
     7261 acaccatcaa tttataaaaa agtaattcaa ttagaacaaa agggatatat tgaaagtaaa
     7321 actgtgaaga atggaaaaat gccagaaaaa gcagtttatt cattaactga attaggtgag
     7381 acacattttt tagatttaat gtttgataca tctagcaaac caataaatat tcttttagat
     7441 tttaatgctg ttatagtaaa tttaaatagc cttacaccag aaaaacagaa attatgtctc
     7501 aataatattg aagagaatgt tcaagagtta aagaaaacta ttgaggaaaa tataagtata
     7561 aagacagaag taccagacac agcaaaagca gtgttggagc aacagttggt gctagcacaa
     7621 gcattggaaa cctggataaa ttctttaaaa gataatatgg gaaattagaa ttagagaagc
     7681 taacttaata atcattaaac aaaaaccagc atatttaata atgagatatt agaaaaaata
     7741 aaacaaatga tataaactga aaagtatatt taaaataaag ctcacttaat tgagggagaa
     7801 tgttaaactt tt
//
LOCUS       DAEPID010000126         7609 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.127, whole genome shotgun sequence.
ACCESSION   DAEPID010000126 DAEPID010000000
VERSION     DAEPID010000126.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 7609)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7609)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..7609
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.127"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            <1..278
                     /locus_tag="KR257_003556"
     CDS             <1..278
                     /locus_tag="KR257_003556"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896756.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=3
                     /transl_table=11
                     /product="GIY-YIG nuclease family protein"
                     /protein_id="HBH0032212.1"
                     /translation="SLYTGYTSNIVRRMNEHKLGINSKYTRAKGFEKLEVYFVTNTKS
                     NAMKLEYYIKKLTRNKKLSIIKNPSILINLIDNKEDYIIGKEIEQLT"
     regulatory      371..463
                     /regulatory_class="riboswitch"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00059"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="TPP riboswitch; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /bound_moiety="thiamine pyrophosphate"
                     /db_xref="RFAM:RF00059"
     gene            563..1357
                     /gene="thiD"
                     /locus_tag="KR257_003557"
     CDS             563..1357
                     /gene="thiD"
                     /locus_tag="KR257_003557"
                     /EC_number="2.7.1.49"
                     /EC_number="2.7.4.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430015.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional hydroxymethylpyrimidine
                     kinase/phosphomethylpyrimidine kinase"
                     /protein_id="HBH0032213.1"
                     /translation="MSNYKIPTLTIAGSDSSGGAGIQADLKTFSAIGTYGMSVITAIT
                     AQNTKGVFAVEDLNKKIIKKQIEAVFEDIPPRAVKIGMVSSPEIILEIVENLKKYNPK
                     YLVVDPVMISKSGYYLLKPEAKENLIKYLIPLAYIITPNIPEAEEITGIKIHNVDDMK
                     RVGEEILQLGPKFVLMKGGHLDGEAVDILVGKNIFKVYKSERIDKKNTHGTGCTLSSA
                     ITSYLALGYEITEAVNLSKIYITEAIKRSFDIGHGVGPVHHFYKFE"
     gene            1381..2169
                     /gene="thiM"
                     /locus_tag="KR257_003558"
     CDS             1381..2169
                     /gene="thiM"
                     /locus_tag="KR257_003558"
                     /EC_number="2.7.1.50"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018112777.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hydroxyethylthiazole kinase"
                     /protein_id="HBH0032214.1"
                     /translation="MYNLIKDVKKLNPLVIHYTNNVTINDCANVTLAVGASPLMSFSY
                     EEVEEMVSVANSVVINIGTMNSNMLDLFLLAGKAANKYNKPVVLDPVGVFASKARAEL
                     TSRLLNEVKFSVVKGNVSEIKFIGGFNVRGKGVDSFDEEEDSTEIIRKIAEKLECVVV
                     ATGKIDIITNGKGTYKINNGTDKLKGITGTGCMTASLIASFMAVTENILEAATMGVLT
                     MSLSGELANLNNPPIGTFKENLMNAIYQMDIDTLSKNSNIEFLN"
     gene            2192..2824
                     /gene="thiE"
                     /locus_tag="KR257_003559"
     CDS             2192..2824
                     /gene="thiE"
                     /locus_tag="KR257_003559"
                     /EC_number="2.5.1.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436488.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="thiamine phosphate synthase"
                     /protein_id="HBH0032215.1"
                     /translation="MIDKESLKKCLKLYLVTDSEMLKGRDFYKCLEDAISSGITTVQL
                     REKNASGREFLRKAMKLREITKQYGVKFIINDRVDIALICDADGVHVGQSDIDVREVR
                     KLIGNNKILGVSARTLEEAICAKNDGADYLGVGSIFTTSTKLDAKSASFETVKEIKEK
                     VDMPFVLIGGINLDNIDKLKCLESDGYAIISAILKAEDISKEVEKWTLKI"
     gene            2963..3265
                     /locus_tag="KR257_003560"
     CDS             2963..3265
                     /locus_tag="KR257_003560"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436486.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIB"
                     /protein_id="HBH0032216.1"
                     /translation="MIRILLVCVGGMSSTLLVNKMEKDAKKRNIDCKIWAVGEGDIKS
                     ELDNFDILLLGPQLRFMLDDVKSIVGDRAPVSIIDMVNYGTCNGHAVLNSVLEILK"
     gene            complement(3331..4080)
                     /locus_tag="KR257_003561"
     CDS             complement(3331..4080)
                     /locus_tag="KR257_003561"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889499.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBH0032217.1"
                     /translation="MLNILWRSMKWRFKNPISFVVTILQPFLWLVLYSSIANQTMNNI
                     NINNYTAFILPGIIVLVVFSSCSSGGIINFIMKNSGSFYRVLIAPISRYSIVLGQLLE
                     AILVSFIEVTILCIVSIFFSVRIESGIGGILLMIVLIFMTAFFLSSLAYSISLLLPNE
                     IVYETIMTAIVLPIFFLSSALFPIESLSGGLKVAVMLNPFTHVINALRSLIFGETILI
                     GDILPVILLFLILCCSSFSLAMWRLKKEMVS"
     gene            complement(4074..5036)
                     /locus_tag="KR257_003562"
     CDS             complement(4074..5036)
                     /locus_tag="KR257_003562"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896762.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBH0032218.1"
                     /translation="MLAIEIDNLVKEYKNGVKALNGLSFNVNAGEIFSLLGPNGAGKS
                     SLINILTTFYKPTSGNVTMFGKDLVDNPSWIRTQIACVAQQISIDEHLSLMENMVFQS
                     KMYKVEPQIAKQRIDSLIDKFDLSSYLKYPTSSYSGGVKRRLDIAMNMVSSPKILFLD
                     EPTVGMDVDSRKSMWDMLLKIRDEYGTTIFLTTHYLEEAEQLSDNICIMKNGKDLAQG
                     TPSSLRSYIRQNILRITFHNTEDIKKYKDSIKSTGLVKFMSVRENSIFISVNDSRTAF
                     TLINKWLLEHDIEFDAIEIVEPSLEDVFLALTSSKKSLKEEWEC"
     gene            complement(5040..5498)
                     /locus_tag="KR257_003563"
     CDS             complement(5040..5498)
                     /locus_tag="KR257_003563"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728863.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GyrI-like domain-containing protein"
                     /protein_id="HBH0032219.1"
                     /translation="MNCKIEIKNIESVTVATMRYNGPMTEATKYFPNVFKAIKGKSNG
                     APFFCYYDVDQKTGVAEMELCVPTAETPNRMGITTKEFPKTKALFFTHTGSYSNLPKT
                     YEMIFKYIHENNIKIQTPWREVFIKGPGMLIKGNPDNYITEIIFPLKEEE"
     gene            5854..6210
                     /locus_tag="KR257_003564"
     CDS             5854..6210
                     /locus_tag="KR257_003564"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436478.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GntR family transcriptional regulator"
                     /protein_id="HBH0032220.1"
                     /translation="MNFELDNTTPIYLQIVKYIKRQIVTGELKPGETIPSRREMALNL
                     KVNLNTVQRAYKEMGDMNIINTFKNYQSSVTVDENILKNLKLELINESLSVFIEDMKA
                     INVSKEEVLKIIEDKY"
     gene            6282..6998
                     /locus_tag="KR257_003565"
     CDS             6282..6998
                     /locus_tag="KR257_003565"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009905518.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBH0032221.1"
                     /translation="MIEIKNVSKTYKRMQGLKIRKIEALKNVSFNIEKGKITALLGIN
                     GVGKSTMLKAIAGLINIDSGEIRIDGEKINEKVYNKLAFVPDVQSHFSNTTIKETFEF
                     MEIFYSKWNKEKSKEMMDIFKLDEDEIIDNLSKGNIARVKLILGFCQDPEYILLDEPF
                     TGIDLFKREEFIGVIAQYMEENQAIIITTHEIVEIESLVDEVVILDEGQIITSFNAEE
                     LREREGKSILDKMREVYKNE"
     gene            6991..>7609
                     /locus_tag="KR257_003566"
     CDS             6991..>7609
                     /locus_tag="KR257_003566"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430026.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBH0032222.1"
                     /translation="MNKLLYLINVDLRRSNKFYIAYISFFSLITLSLNLFEINKFKNS
                     KFIMNLAIEDFGGIFYGLGILSNLGFIQSILFFGILGLFIYYVFMWKREFFSNNQSIY
                     TLMMLPQNKFKICISKSIALITMIYGFLISQTATLFICKYIFNFIFRNMPIINMNFAK
                     DLYYLNLKSIPIDFISFMAIYVFLLLIAISIVNCCILFIFSYINKF"
BASE COUNT         2960 a          893 c         1244 g         2512 t
ORIGIN      
        1 attctctata cactggatat accagtaata tagttagaag aatgaatgaa cataaattag
       61 gaattaattc aaaatacaca agagcaaagg gatttgaaaa actagaagtt tattttgtga
      121 ccaacacaaa aagcaatgct atgaagttag aatattatat aaaaaaatta actagaaata
      181 aaaaattgtc tataataaaa aacccaagta tacttataaa tttaattgat aataaagaag
      241 attatattat tggtaaggaa atagaacaat taacataaat atttatagta acattataat
      301 gggtgcatat ggtgtaaaaa cttgacaata aatactattg taatataatg aagttataaa
      361 tatagtaaat taaaatagct aggggagcca agagctgaga ggtataccga cccttacacc
      421 tgatctggat aataccagcg taggaaagct tagtaaaaat tcaagtatgt attatttgtg
      481 atatatgcta tttctaagct atacctattg taggtatagc ttttttaatt aagttattta
      541 aattaaactt taggaggcaa caatgagtaa ttataaaata ccaacactta caatagccgg
      601 ctctgattca tctggaggag ctgggattca ggctgatttg aaaacgttta gtgcaattgg
      661 tacttatggt atgagtgtaa taacagctat aacagcacag aatactaaag gagtttttgc
      721 tgtagaggat ttaaataaga aaataataaa aaaacaaata gaggcagtct ttgaagatat
      781 acctccaaga gctgtaaaaa taggaatggt ttcaagtcct gagattatac ttgaaatagt
      841 tgagaatcta aagaaataca atccaaaata tttggttgtg gacccagtaa tgatatctaa
      901 aagtggatat tatctattaa agccagaggc aaaagaaaac ttaattaagt atttgatacc
      961 acttgcatac ataattacac caaatatacc agaggcagaa gaaataacag gaataaaaat
     1021 acataatgta gatgatatga agagagtagg agaagaaata ctacaacttg gacctaaatt
     1081 tgtacttatg aaagggggtc atttagatgg agaagcagtg gatattttag ttggtaaaaa
     1141 tatatttaaa gtttataaaa gtgaaagaat tgataaaaaa aatacacatg gaacagggtg
     1201 cacattatct tctgcaataa catcttatct agcattagga tatgaaataa cagaagcagt
     1261 aaatctaagt aaaatctata taacagaagc aataaaaaga agttttgata taggtcatgg
     1321 agtaggacca gtacatcatt tttataaatt tgagtaataa aaaaatattg gaggtagaat
     1381 atgtataatt taattaaaga tgtaaaaaaa ttaaatccat tggtaattca ttatactaat
     1441 aatgtaacta taaatgattg tgctaatgta actttagctg taggagcaag tcctcttatg
     1501 agtttttcat atgaggaagt agaagaaatg gtaagtgtag caaactctgt agtaataaat
     1561 ataggaacta tgaactcaaa tatgttggat ttattcctat tagctggaaa agcagcaaat
     1621 aagtacaata aacctgttgt tttggaccca gttggagtat ttgcaagcaa agcgagagca
     1681 gaacttacaa gtagactttt aaatgaagtc aaatttagtg ttgttaaagg gaatgtatca
     1741 gaaataaagt ttataggtgg ctttaatgta aggggtaaag gtgtagattc atttgatgaa
     1801 gaagaagatt ctactgagat aataagaaag attgctgaaa agcttgaatg tgtagttgta
     1861 gcaactggaa aaatagatat aataactaat ggtaaaggta catataaaat aaacaatgga
     1921 actgataaat taaaaggaat tacaggaact ggatgtatga ctgctagctt gattgcaagt
     1981 tttatggctg ttactgagaa tatattagaa gcagcaacaa tgggtgttct tacaatgtct
     2041 ttaagtgggg aattagctaa tttaaataat ccaccaatag gtacatttaa agaaaatctt
     2101 atgaatgcta tttatcaaat ggatatagat actttaagta aaaattctaa tattgaattt
     2161 ttaaattaat aaagagtaag ggagacttaa aatgattgat aaagaatctt taaaaaaatg
     2221 tttaaagttg tatttagtaa ctgactctga aatgcttaaa ggtagagact tttataaatg
     2281 tcttgaagat gcaatatctt ctggaataac aactgtacaa cttagagaaa aaaatgcttc
     2341 tggaagagag tttttaagaa aagctatgaa acttagagaa ataactaaac aatatggtgt
     2401 taagtttata ataaatgata gagtggatat agcacttatt tgtgatgcag atggagtaca
     2461 tgtaggacag agtgacattg atgttagaga ggttagaaag cttataggaa acaataaaat
     2521 tctaggagta tcagcaagaa ctttagaaga agctatttgt gcaaaaaatg atggcgcaga
     2581 ctatttaggt gtagggtcta tattcacaac atctactaaa ttagatgcaa aatcagcttc
     2641 gtttgaaact gttaaagaaa ttaaagaaaa agtagacatg ccatttgtac taattggagg
     2701 tataaattta gacaatatag ataaacttaa atgtttagaa agtgacgggt atgctataat
     2761 atcagctata ttaaaagctg aagatatctc taaagaagtg gaaaagtgga cattaaaaat
     2821 ataaaattgg ctctggtagt gaaaaaaatg gaaaaatttg atataatcta agagtaaaat
     2881 ttaagcaatt ataaatgata aacttttcta catatacttt ttaatcaaga tatatgtaga
     2941 tttggttaaa aaggagctat aaatgattag gatattgtta gtgtgtgttg gaggcatgtc
     3001 ttctacccta ttggtaaata aaatggagaa ggatgcaaaa aaaagaaata tagactgtaa
     3061 aatatgggca gttggagaag gagatataaa atcggagctt gataactttg atattttact
     3121 tcttggacca caacttagat ttatgcttga tgacgtaaag tctatagttg gagatagagc
     3181 tccagtatct ataatagata tggtaaacta tggcacttgt aatggtcatg ctgtgttaaa
     3241 ttcggtttta gaaatattaa aataaataat aaaagtggat tctatataat agagtccatt
     3301 tttattattt gttattaata ggcttaaaac ttagcttacc atttcttttt ttaatctcca
     3361 catagcaagt gaaaaacttg aacagcacaa tattaaaaat agtaggataa caggcagtat
     3421 atctccaata agaatagtct caccaaatat taagctacgt aaagcgttaa taacatgggt
     3481 aaatggattg agcatcactg ctacttttaa tcctccagat aaactttcta tagggaaaag
     3541 agctgaactt aaaaagaaaa taggaagtac aattgcagtc ataattgttt cataaactat
     3601 ttcatttggc aataataaac ttatagaata agctagactt gataaaaaga aggctgtcat
     3661 aaatatcagt actatcataa gtaggattcc accaatgcca gattctatcc ttactgagaa
     3721 gaatatactt actatacaca aaatagttac ttctatgaaa gaaactaaga tagcttctaa
     3781 taattgacca aggacgattg aatacctact gataggtgca attaagactc tatagaaact
     3841 tccactgttc ttcattataa agtttataat accaccacta ctacaagaag aaaacacaac
     3901 cagtacaatg atacctggta gtataaaagc agtataatta ttgatattta tattattcat
     3961 agtttggttt gcaatagaac tataaagcac aagccaaaga aaaggttgta atatagtaac
     4021 tacaaatgag attggatttt taaaacgcca cttcatacta cgccataaga tatttaacat
     4081 tcccattcct cctttaagct ttttttagaa cttgtaagtg ctaaaaatac atcttcgaga
     4141 cttggctcta caatttctat tgcatcaaat tctatatcat gttctaaaag ccatttattt
     4201 attaaagtaa aagcagttct actatcgttt acacttataa aaattgaatt ttctcgtacg
     4261 ctcataaact ttactaaacc agtactttta attgaatctt tatatttttt tatatcttca
     4321 gtattatgaa aagttatacg tagtatattt tgtctaatgt aactacgtaa acttgatggt
     4381 gttccttgtg ctaaatcctt tccattcttc ataatacaaa tattatcact caattgttca
     4441 gcttcttcaa gataatgagt agttagaaat atagttgtgc catactcatc tctaattttt
     4501 aataacatat cccacataga ttttcttgaa tcgacatcca taccaacagt tggttcatct
     4561 aaaaatagga ttttaggaga tgataccata ttcatagcta tgtccaatct acgttttaca
     4621 ccccctgaat atgatgaagt aggatatttt aagtaactag ataagtcaaa cttatcaatt
     4681 aaagagtcta ttctttgttt tgcaatctgt ggttctactt tatacatttt actttgaaat
     4741 accatatttt ccataaggga taaatgttca tcaatagaga tttgctgtgc tacacaagca
     4801 atttgagtac gtatccaaga aggattatct actaaatctt ttccaaacat tgttacattt
     4861 ccagatgtag gtttgtaaaa ggtagtcaaa atatttataa gagaagattt accagcacca
     4921 ttaggaccaa gtaaagaaaa aatttctcca gcatttacat taaagcttag accatttaaa
     4981 gctttcacac catttttata ttcttttact aaattgtcta tttcaatcgc taacatatat
     5041 tattcctcct ctttaagtgg aaatattatc tctgtaatat agttatctgg gtttcctttt
     5101 atcaacatac ctggtccttt aataaatact tctctccaag gagtttgtat ttttatatta
     5161 ttttcatgaa tatatttaaa tatcatttca tacgtttttg gcaaattact ataagagcct
     5221 gtgtgagtaa aaaataaagc ttttgtttta ggaaattctt ttgtagttat acccatacga
     5281 tttggagttt cagcagttgg aacacataat tccatttctg caacaccagt tttttggtca
     5341 acatcatagt agcaaaagaa tggtgcaccg ttagactttc cttttatagc tttaaataca
     5401 tttggaaaat actttgttgc ctcagtcata ggtccattat aacgcatggt agccactgtg
     5461 actgattcga tatttttgat ttcaattttg caattcattt gtttacctcc taatgtgtgt
     5521 tcatattctt actagatttt taagcattaa tacatataag attttgatta gttgaaaaca
     5581 tataatctta tctcgtttgc ttgttttcaa gtctaacata acataaaata tatatcctct
     5641 catttgatgc tccattttgt aaagttatta tttaagcttt actttagatt ttttagcaaa
     5701 ttaaaataaa gcaatttata aaataagtat ttacaaatta agtgtattaa tcgtataata
     5761 cacttaatag gatactagat aaagtctgaa ataaaggcgt atttttttaa agtaagtgta
     5821 ctatcgtatt aatacactag aataggagga atcatgaatt ttgaattaga taatacaact
     5881 cccatttatt tgcaaatagt aaagtatata aagagacaaa tagtaacagg agagttgaaa
     5941 ccaggagaga caataccatc aagaagagaa atggcactta atctaaaagt aaacttaaat
     6001 acagttcaaa gagcatataa ggagatgggt gatatgaata taataaatac ttttaaaaat
     6061 tatcaaagca gtgtaacagt tgatgaaaat atattaaaaa atttaaaatt agagcttata
     6121 aatgaatcac tatctgtttt tatagaagat atgaaagcaa taaatgttag caaagaagaa
     6181 gttttaaaaa taatagaaga taagtattag ttttttaaca aatagaaaac ttagtttaga
     6241 aagtttattt ataagcatat tggatgtgga ggatagtaaa tatgatagaa ataaagaatg
     6301 tcagcaaaac atataaaagg atgcaagggc ttaaaataag aaagatagaa gctttaaaaa
     6361 atgtaagttt taatatagaa aagggaaaaa taactgcatt acttggtata aatggtgttg
     6421 gtaaatcaac tatgttaaaa gcaatagcag gacttataaa cattgatagt ggagaaattc
     6481 gtatagatgg agaaaaaata aatgaaaaag tatacaataa attggctttt gttccagatg
     6541 tacaatctca ctttagcaat acaacaataa aagaaacatt tgaatttatg gaaatttttt
     6601 attcaaagtg gaataaagaa aaatcaaaag aaatgatgga catatttaaa ttggatgaag
     6661 atgaaataat tgataacttg tcaaaaggaa acattgcaag agtaaaatta atacttggat
     6721 tttgccaaga cccagagtac atacttcttg atgaaccatt tacaggaatt gatttgttta
     6781 agagggaaga gtttatagga gtaatagcgc aatatatgga ggaaaatcaa gccattatca
     6841 taactactca tgagatagta gagatagaaa gtttagttga tgaggttgta attcttgatg
     6901 aagggcagat tataacttca tttaatgcag aagaattaag agaaagagaa ggtaaatcta
     6961 tattagataa gatgagggag gtatataaga atgaataaac ttctatatct aataaatgta
     7021 gatttgagaa gaagcaataa gttttatata gcttatatat catttttttc attaattaca
     7081 cttagtttaa atttattcga aattaataaa tttaaaaatt ctaaatttat tatgaactta
     7141 gcaatagaag attttggagg tatattttat ggactaggga tacttagtaa tcttggtttt
     7201 atccaaagta tattgttctt tgggatattg ggacttttta tatactatgt ttttatgtgg
     7261 aaaagagagt tcttttcaaa taatcaaagt atttatacac ttatgatgtt acctcaaaat
     7321 aagtttaaga tttgtatatc taaatcaata gccttgataa caatgatata tggttttttg
     7381 ataagtcaga cagcaacatt atttatatgt aaatatatat ttaatttcat ttttagaaat
     7441 atgcctataa tcaatatgaa ctttgccaaa gatttatatt atttaaactt gaagagtata
     7501 ccaattgatt ttatctcttt tatggctatt tatgtatttt tactacttat agctatttct
     7561 attgtaaatt gctgtatatt atttatcttt tcctatataa ataaatttt
//
LOCUS       DAEPID010000127         7156 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.128, whole genome shotgun sequence.
ACCESSION   DAEPID010000127 DAEPID010000000
VERSION     DAEPID010000127.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 7156)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7156)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..7156
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.128"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            complement(<1..542)
                     /locus_tag="KR257_003567"
     CDS             complement(<1..542)
                     /locus_tag="KR257_003567"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861600.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="HBH0032223.1"
                     /translation="MIAVKKAYKFRMYPNKKQQELINKTFGCCRFVYNKYLAKRIDVY
                     KNDKETFTYKQCSSDLTNLKKELKWLKEPDKFSLQNALKDLDNAYKKFFKEKAGFPKF
                     KSKKINRFSYKTNFTNGNIMYCGQHIKLPKLGMVKIRDKQVPQGRILNATISKEPSGR
                     YYVSLCCTDVDIEAFENTNN"
     gene            complement(1190..1597)
                     /locus_tag="KR257_003568"
     CDS             complement(1190..1597)
                     /locus_tag="KR257_003568"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434095.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0032224.1"
                     /translation="MSKVAKATFYLMIVTIISKILGMGRELVLSSIYGTGLYTESYLT
                     AMNIPNIIFAAIGTAIVTTFIPMYQDISSKQGEKQALKFLNNVLNIIVGICIVVAILG
                     VIFSKQLVSIFAIGFEGERFLLTVKFTKILIKK"
     gene            complement(2071..2955)
                     /locus_tag="KR257_003569"
     CDS             complement(2071..2955)
                     /locus_tag="KR257_003569"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889336.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sigma-70 family RNA polymerase sigma factor"
                     /protein_id="HBH0032225.1"
                     /translation="MDTKKENNYENYICVGSSNVSNAMKMYLKEIEEYKMLSAGEEVE
                     LAKEIINSSSVAKEKFINSNYRLVVSIAKRYKRDSIDMLDLIQAGNIGLIKAVEKYDY
                     KKGYKFSTYATWWIKQSITRYIDDCENTIRIPIHLHQRINFVKKKKQELLNVLLREPT
                     IDEIADACGLEVDKVLELLRRDKNVVSLDTPLKEDEDSSLVEFIPSDADFKDVVIHEV
                     EQHNLKEKIEELLTGLGEQEQQVLRMRFGIDDDDPKTLEQIGKVFGVTRERIRQIEAK
                     AIRKLRHPSKLKQLKHFY"
     gene            complement(3246..3722)
                     /locus_tag="KR257_003570"
     CDS             complement(3246..3722)
                     /locus_tag="KR257_003570"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889335.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type I restriction enzyme HsdR N-terminal
                     domain-containing protein"
                     /protein_id="HBH0032226.1"
                     /translation="MSKELVKDRVIKYLIEDLLVPQDMIDTNVELAEFEEGAEGILDI
                     VVNVKDEEDYYAPVMIVQCLDEDVELEGEVLQKQIEFLEEVDNITMSGRLVLTNGDAM
                     MYADWRGEEYDTEAALPTYDIMVKEFHEMEQQVKDLEEHHHHDENCGCGCNHHHEN"
     gene            3988..5163
                     /locus_tag="KR257_003571"
     CDS             3988..5163
                     /locus_tag="KR257_003571"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419970.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1002 domain-containing protein"
                     /protein_id="HBH0032227.1"
                     /translation="MKFKKQISSIVVSTMLVLGSMNLSYADGTNVVTLGANLSESQKQ
                     QMLNYFGVKKDQVLVLDVTNAEERQYLQGVATEGQLGKVTISCSYVEPTKKGNGINVK
                     TANLTWVTSSMIASTLTTAGLEDANVIAAAPYPVSGTGALTGIMKAFEDASGKKLDET
                     KKEIASEELVVTGDLGDDIGQEKATGVMNDIKTEIVKNGTKDTNQIANTINNVVNNYN
                     ITITPEQKEQIKGVMKKIADQNYDYNSMKNTLDNVSDNVNEQLKKLGESVKGSGILDT
                     IGGWFSGIGDWFSGLFSGGDKKDLGILNNTNDESLGSDAVINSTEGVQINPQNNTNSN
                     NDSDTNSSKNDTSSNNENNDSSQTNENNTTNNSENQSNNNDSVGFFEKIKNWLSGLF"
     gene            complement(5244..6047)
                     /gene="proC"
                     /locus_tag="KR257_003572"
     CDS             complement(5244..6047)
                     /gene="proC"
                     /locus_tag="KR257_003572"
                     /EC_number="1.5.1.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419967.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pyrroline-5-carboxylate reductase"
                     /protein_id="HBH0032228.1"
                     /translation="MKKIGFIGAGNMASAMIGGIVNSKLVEPNMVIASAYSQGTLDRI
                     DANFGINTTKDSKEVTRTSDIVIVAVKPDIYDDILEEIKDFIDDNKIIVTIAAGKSIK
                     DIESIIGEDKKIVRTMPNTPALVNEAMSSLSINKNINKEDLEAVTEVFNSFGNTEVVP
                     EYLIEAVIGASGSAPAYVFLFIEAIADAAVIAGMPRPQAYKFASQAVMGSAKMVLETG
                     KHPGELKDMVCSPGGTTIEAVKVLEEEGFRASVIKAICACIEKSKKMSE"
     gene            complement(6087..6671)
                     /locus_tag="KR257_003573"
     CDS             complement(6087..6671)
                     /locus_tag="KR257_003573"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889331.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HBH0032229.1"
                     /translation="MNKDIGAKIKQLRTQKQMTLKDMSEKTNLSIGFLSQLERGLTSV
                     ATDSLGKIASVLDVELTYFFMKPKEHKRAVLRSYEKEVFDVENSTFIHYHLSSSLKEK
                     TMLPRLIEILPSKSSEEICCYVHEGEEFVYVLEGTLTVFLGDEQIEMYPGDTIHYNSE
                     KNNHNWVNYTNKVVKILVVSIPNPFEKSDAVKEA"
BASE COUNT         2345 a         1196 c          802 g         2813 t
ORIGIN      
        1 tgattattag tattttcaaa tgcttcaata tctacatcag tacagcataa tgatacataa
       61 tatctaccac ttggctcttt agatatagta gcattaagta ttctaccttg aggtacttgt
      121 ttatccctta tcttaaccat accaagttta ggtagtttta tatgttgacc acaatacata
      181 atgtttccat ttgtaaagtt agttttatat gaaaatctat taattttctt tgatttaaat
      241 ttaggaaatc ctgctttttc tttaaagaat tttttatatg cattatctaa atcttttaag
      301 gcgttttgta gtgaaaattt gtcaggttct ttaagccatt ttaattcttt ttttaaattg
      361 gtcaaatcag aactacactg tttataagta aaagtttctt tatcgttttt ataaacatct
      421 attcttttag caagatactt attatataca aatctacaac atccaaaagt tttgttaatt
      481 aactcttgtt gttttttatt tggatacatt ctaaacttat aagctttttt cactgctatc
      541 acctcacttt aattgttttt tgatacactt tttaatgatt ttatcacatt ttatcacatt
      601 taatatatta tataatgctg tggtaaacaa tttattaatc acctataata atgttaacaa
      661 atgtaattat ttaaaacaat tatttagaag gttttatatt taattttaaa taacatattt
      721 aagaaccgta agtcttaact tttatcattt tgaggttgtc gttcacataa gttcgctact
      781 acctatgcag ttctcttatg aacttcttac attttcatgt aagcacagac tatatcttat
      841 ccttcagcat tatccgttaa ggtctaccca cttccactac caatagcttg tagtgtactt
      901 ccctcaagag gaatagtcgt tgaagtttct cctgttcgga gtttacctgc tgattgccca
      961 ttttaaagta cttaggattt aaccttatac catctaacca attttttcta ctttcgtaac
     1021 tttcacactt aggtttattt catccttatg ttttagtttg attagcttta ggggtttcca
     1081 gcaattcaag tagtattgga taggttctat cctatctcta catataggtt tccctatatg
     1141 ctgactattt tagctactaa ctcatgacta aagtcacgag tgtgtgtagc tattttttaa
     1201 tcaatatttt agtaaatttt acggtaagta aaaacctctc tccttcaaat cctatagcaa
     1261 atatacttac aagttgcttt gagaaaataa ctcctaatat agctacaact atgcatatac
     1321 caactattat atttaaaaca ttgtttaaaa actttagtgc ttgcttttca ccttgtttac
     1381 tacttatatc ttgatacatt ggaataaaag tagtaactat agcagtacct attgctgcaa
     1441 atataatatt tggtatattc atagctgtta aataactctc tgtatataag cctgtaccat
     1501 aaattgatga taatactaat tctctaccca ttccaagaat cttagagatt atagtaacta
     1561 tcatcaaata aaaagttgct ttagctacct tgctcatttt atcactccac ttctaacata
     1621 cctcttttta atcaagtaaa atttagctca ttagatataa ttctatcaac taatttgcct
     1681 tgcttagccc tatcaaaata taattaacac ctatttctta atatatcaca aactacatta
     1741 ttcttcatat ttttttattt ctccaataag ttttacattt ttcctatata aattgtatag
     1801 cttcaattat attcaaagaa atggagttgc tacccgataa ctttaaaagt aaaaaacaga
     1861 ttttattatc tttttaaact atattctaac atattttgtc catattgaga aattttacta
     1921 aactattatg tactttatta aataaataaa ataacagcac acctataaaa tacaagtgtg
     1981 ctgttcataa acagatttta taaaaaaata attcctaagt agagattaac atgctttctc
     2041 atactctcat atataatgtg tctaaaaata ttaataaaaa tgttttaatt gttttaactt
     2101 acttggatgt cttaattttc ttattgcttt agcttctatc tgtcttattc gttctctggt
     2161 aactccaaat acctttccaa tctgttctag tgttttaggg tcatcatcat caattccaaa
     2221 tctcattctt aaaacttgct gttcttgctc tccaagacct gtaagtagtt cttctatctt
     2281 ttcttttaaa ttatgctgtt caacttcgtg tattacaaca tctttaaaat cagcatctga
     2341 tggtataaat tcaactaaac tactatcctc atcttctttt aatggagtat ccaaagatac
     2401 aacattttta tctcttctta ataattccaa cactttgtca acttctaagc cacatgcatc
     2461 tgcaatctca tctatagttg gctctcttaa taatacattt aaaagttctt gtttcttttt
     2521 ctttacaaaa tttattctct gatgaagatg tataggtatc ctaatagtat tttcgcaatc
     2581 gtcgatatat cttgttatac tttgttttat ccaccaagtt gcataagtgc taaatttgta
     2641 tcctttttta taatcgtact tttctacagc ttttataagt cctatatttc ctgcttgaat
     2701 taaatccaac atatcaatac tatctctttt atatctcttt gctatgctca ctaccaacct
     2761 ataatttgaa tttataaatt tttcttttgc tactgaagat gagttgatta tttccttagc
     2821 cagctctacc tcttctcctg ctgacaacat tttgtattcc tctatttcct ttaaatacat
     2881 tttcatcgca ttcgatacat ttgatgaacc cacacaaata taattttcat aattattttc
     2941 ttttttagta tccataatca aaccccttct attcatagaa tttgctaaaa caaaaataaa
     3001 taatttaaac ctacataatc tacaattaca taatatccca ttctttaaat gaattgtttt
     3061 gtatattatg tatacaaatt tataaaaact atacctataa tattattcta cttctaacag
     3121 caatatcctc cttatatata taatttattt tattatatgt tgttatattc ttagtttttt
     3181 gaatgatata tgtctaaaaa aagactgttt actaaacagt ctttttttat atatatgctc
     3241 aatatttaat tttcatgatg atgattacat ccacatccac aattttcatc atggtgatga
     3301 tgttcttcta aatcttttac ctgttgttcc atttcatgaa actcttttac cattatatca
     3361 taagttggaa gagctgcctc agtatcgtat tcttcccctc tccaatcagc gtacatcata
     3421 gcatctccat tagttaaaac caatctacct gacatagtta tattatccac ttcttctaaa
     3481 aattctattt gtttttgtaa aacttctcct tctaactcca catcttcatc taaacattgc
     3541 actatcatta caggtgcata ataatcttct tcatctttaa catttacaac aatatctaaa
     3601 attccttctg caccttcttc aaattctgcc aactcaacat ttgtatcaat catatcttga
     3661 ggtactaata aatcttctat taaatatttt attactctat cttttactaa ttcttttgac
     3721 atttattttt ctccttccga ttctataaca ttatcataat catttctata ttatagtata
     3781 ctacattaat tgttttttca atctcttaca aaaattattt tttattatct tccttatatt
     3841 ccctttttta ttacaaagtt gtaatcgcat tgatttaaaa aatagtttat atttagtata
     3901 atagaaatgt agcacatatt tttattcaat atattaataa aaaaatatat tgaaaatgta
     3961 atgtatgtta aatctaggag gaatattatg aagtttaaaa aacaaattag ttctattgtt
     4021 gtgtctacta tgcttgtact tgggagtatg aacctttctt atgcagacgg tacaaatgta
     4081 gttacacttg gagctaactt atcagagtct caaaagcagc aaatgcttaa ttactttgga
     4141 gtaaaaaaag accaagtctt agttttagat gtaacaaatg cagaagaaag acagtattta
     4201 caaggtgttg caacagaggg tcaacttgga aaagttacta tctcttgctc atacgttgaa
     4261 cctactaaaa aaggaaatgg aattaatgtt aaaacagcaa acttaacttg ggtaactagt
     4321 tcaatgattg cttcaaccct tacaacagct ggtcttgaag atgcaaatgt tattgctgct
     4381 gctccatatc ctgtaagtgg tactggagca ttgacaggaa tcatgaaagc atttgaggat
     4441 gcttcaggaa agaaacttga tgaaactaag aaagaaattg cttctgaaga attggtagtt
     4501 acaggtgact taggagatga tatagggcaa gaaaaagcaa caggtgtaat gaatgatata
     4561 aaaacagaaa ttgtaaaaaa tggtacaaaa gataccaatc aaatagcaaa tacaataaat
     4621 aatgttgtaa ataattacaa tattactatt acaccagaac aaaaagaaca aattaaaggt
     4681 gtaatgaaaa aaatagctga ccaaaattac gattacaata gcatgaaaaa tacactagat
     4741 aatgtatcag ataatgtaaa tgaacaatta aagaaattag gtgaaagtgt taagggttct
     4801 ggtatactag atactattgg tggatggttt agtggaatag gagactggtt ctctggttta
     4861 ttctcaggcg gagataaaaa agatttggga atcttaaata atactaatga tgagtctctt
     4921 ggctctgatg ctgtaataaa ttctacagaa ggtgttcaaa taaatccaca aaataatact
     4981 aattctaaca atgatagtga tacaaatagc tcaaaaaatg atacttcaag taataatgaa
     5041 aataacgata gttctcaaac aaatgaaaac aacacaacaa ataattcaga aaatcaatca
     5101 aataataatg actcagttgg tttctttgaa aaaataaaaa attggctttc aggcttattt
     5161 tagaaattaa acaaataaaa agaattgcct aaaatggaaa ttttctataa aaggcaattc
     5221 tctttattta caataaattt ttattactca ctcatttttt tagatttttc tatacatgca
     5281 catattgctt ttatcacaga agctctaaaa ccttcttctt caagtacttt aactgcttct
     5341 atagtagttc caccaggtga acataccata tcttttaatt caccaggatg ttttcctgtc
     5401 tcaagtacca tttttgcaga acccataaca gcctgtgatg caaacttata tgcttgtggt
     5461 cttggcattc ctgcaattac tgctgcatct gctatagctt ctataaataa aaatacatat
     5521 gctggtgcag aaccacttgc accaattaca gcttctataa gatactctgg tactacctca
     5581 gtatttccaa aagaattaaa tacttctgta actgcttcta agtcttcttt gtttatattt
     5641 ttatttatag aaagagaaga catggcttca tttacaagag ctggagtatt tggcatagtt
     5701 ctaactattt ttttatcttc tcctataata gactctatat cttttataga ttttcctgct
     5761 gctattgtaa ctataatttt attgtcatct ataaagtctt ttatctcttc caaaatatca
     5821 tcatatatat ctggtttaac agctacaatt actatatcag aggttctagt tacttccttc
     5881 gagtcttttg tagtatttat tccaaaattt gcatctattc tatcaagagt tccttgacta
     5941 tatgctgatg ctataaccat attaggttca actaattttg aatttactat tccccctatc
     6001 atagcgcttg ccatatttcc tgcacctatg aatccaattt ttttcacttt agtacctcct
     6061 tattgactaa tagtaatcgt taaaatttaa gcttctttaa ctgcatcaga cttttcaaat
     6121 ggatttggta tacttactac caaaattttc actaccttat tagtatagtt gacccaatta
     6181 tgattgttct tttcactatt atagtgtatt gtgtctcctg gatacatttc tatttgttca
     6241 tctcccaaaa acactgtaag agtaccctct aatacataca caaattcctc accttcatgt
     6301 acgtaacaac aaatttcctc actactctta cttggaagaa tttcaattaa tcttggtagc
     6361 attgtttttt cctttaaact agatgataaa tgataatgta taaatgttga gttttctaca
     6421 tcaaatactt ctttttcata acttcttaat acagctcttt tatgctcttt tggcttcata
     6481 aaaaagtaag ttaattctac atctagtaca cttgctattt ttcctaagga atctgttgcc
     6541 acacttgtta atcctctttc aagttgtgat aaaaaaccaa ttgacaagtt tgttttttca
     6601 ctcatatcct tcagcgtcat ttgcttttga gttctgagtt gctttatttt tgctcctatg
     6661 tccttattca aaaccatcac ccctaaataa ttttaatttt ttcataatat aaatacaaaa
     6721 atataaatat aggtactgaa cctatcttta tttcatttaa aaaaattttt ataagtatta
     6781 ctataattta tcaatctttt tttgtctaca tttttacgat tatttacgat ttatttttca
     6841 catatgtata tttaatcttg ccaactaaag atacattttt tataagcatt tactctttat
     6901 ataataaaac ttaagttgtt catgagtctt cttctggttt aattattaaa atttcaaatt
     6961 atattattat ttctacacat tattacatcc tttagtacaa ttataacata attttacaat
     7021 ttaatgatat ctattcaatg tcttttttta ctctacaaca tattttattt tagagtttaa
     7081 tactatatat attttttata tacagccttg tcatttttta gattgtcaag agttattgaa
     7141 gtattttatg tagatt
//
LOCUS       DAEPID010000128         7100 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.129, whole genome shotgun sequence.
ACCESSION   DAEPID010000128 DAEPID010000000
VERSION     DAEPID010000128.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 7100)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7100)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..7100
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.129"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            34..2268
                     /locus_tag="KR257_003574"
     CDS             34..2268
                     /locus_tag="KR257_003574"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902499.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="EAL domain-containing protein"
                     /protein_id="HBH0032230.1"
                     /translation="MQNHNYIKMLNKKVEVLSKELDSRNFKLKTLNEIDFFSKIPNRE
                     FMYQHIDDCISKNIHIGIMLLNIDNFKLFNDIYGYLVGENLLITLTQNLLHFIPESKG
                     IVAYLKGEGFLIVLPNVSNKELNNMGATIIESARELKIKLPNEKEIYSNVTFSIGSTI
                     WNGEPNMTTLMLFNQVYSALKKAKSEGKNRYILFDFKDNSFYNKLENDKEFLSEISHV
                     LQTKQIEVFYQPLYNIKNNTIVGCEALARWRHPIKGLLTPDKFIPLFEQFGLITELDL
                     HLFEENCKNIRRWIDNNDVFVPICCNFSRLHFFNPNFPSMLKGITEKYSVSTSNFSIE
                     ITENILIENTNTIIQQLAELRSYGFSVSMDDFGSGYSSFGMLQNLPFDIIKIDRIFLS
                     HNLNDFKNTTILYSIINIARALGMLTVCEGVETEQHVEFIKSINCDIAQGYYYAKPME
                     CKEFEKLLSKENNSEKMFIKYSDIGKSLIEKIFDGFFIMQDMKKLRANVTEDIQWFDF
                     YNKTEITSFPKVIEHFEKHIKGKKFSILYKSITPHNTESDSLLISGEAVLSDEASEHQ
                     KYSNFYFSANCIISENKLLLAKLHLDLIKTAGYINEFESYSIPKMTNTHLDESNILSQ
                     FYSMLPVGIIRYDLFGDMIITYMNEEMFDIIGYTKEQFFGEMGGNLRAIVHPDDLDFV
                     YKKSLDMIDTNKIEPFLYRFIKRDGQIVTVMYTQCNLSAIDGRSIAQGMYVDVNKIKN
                     LTKI"
     gene            2299..3132
                     /locus_tag="KR257_003575"
     CDS             2299..3132
                     /locus_tag="KR257_003575"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902498.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GGDEF domain-containing protein"
                     /protein_id="HBH0032231.1"
                     /translation="MFKEIFLRTFPGFLIIRDSNYRIIFINDNLKNLIKSYMQDNPLG
                     MTNIEIAKKLPDNIAKFFTDSHNIQLDWEKNYPYDKISNWILEFKKDTTSYWNVLEYK
                     VDVDEKTYIITMANDITKLYEENKRNLHYSITDPLTGAYNRKYLNDRFDIFIGDYIVL
                     IDLDNFKMINDYEGHNVGDKILCDFVSLLNKELINSTSIIRLGGDEFIVIFSSDVDKN
                     YVYSQLEALRENFLKVFSKYKYLSFSYGVDTVKRNLKLTIVELDKKMYKNKKKFDKND
                     Y"
     gene            3372..5105
                     /locus_tag="KR257_003576"
     CDS             3372..5105
                     /locus_tag="KR257_003576"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429367.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="diguanylate cyclase"
                     /protein_id="HBH0032232.1"
                     /translation="MSILLKKAPKLAKHIITSFYINRDIDEVLKYLCENVTWIGPGEQ
                     EFLTSFNEIKNYFYAGQDEIPSCDINNDIFETVSEDENRCMVLGRYTVRTKENTQMIL
                     EVNQRCTFEIIEDRGKLLVKHMHISNPYGEMQLDEYFPTKIGTQSYDYLQRLLKEKTE
                     VIEMITNNINGGLKGSNDDNTYSFFYVNEGLPKILGYTYDEFMEMSGGSAVGAVYPPD
                     LPKALEDCERCFAKGPTYSSEYRIRKKDGTLMWVLDSGMKSLNSDGIVKINSIITDIT
                     QLKNIESELKLERERYRIALQNITDIMFEYDIENDTLIKYQRVEIDKKIELENFETKN
                     YSKLLESGKIIHLDDIGKLLEVLHGNLRETIEIRQVNSLTKNEWRWIRVQCSVIYDSD
                     HNPIKTIGVLKDITEDKSKLESLINQAQRDPLTQLYNQRVSQNLIEEYLCSSDSKNND
                     ALLVIDIDDFKTVNDTFGHLEGNEVLVAVSKILLHNTHDKDIVARIGGDEFTIFIKSL
                     TKDLIIKITNDILNDASKIKVKDNHKITLSIGIAFTDDSTKLYKDLFSKADKALYLSK
                     ADGKNCYSTYE"
     gene            complement(6189..6293)
                     /locus_tag="KR257_003577"
     CDS             complement(6189..6293)
                     /locus_tag="KR257_003577"
                     /inference="COORDINATES: protein motif:HMM:NF024729.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS3 family transposase"
                     /protein_id="HBH0032233.1"
                     /translation="MDDYIYYYNNFRYQNRLNSMSPFEFRKYLSTERA"
     gene            6918..>7100
                     /locus_tag="KR257_003578"
     CDS             6918..>7100
                     /locus_tag="KR257_003578"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438567.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0032234.1"
                     /translation="MNQKKIKISIKMVIIGIFAVIIAFVLSRLFVEYIDELLRSNWQY
                     QLFESESSYIVFANCIM"
BASE COUNT         2853 a          835 c          972 g         2440 t
ORIGIN      
        1 attaaaattt aaagtatctt atggaggaat accatgcaaa atcataatta tataaaaatg
       61 ttaaataaaa aggtagaagt attatctaag gaattagata gtagaaattt taaattaaaa
      121 accttaaatg aaatagattt tttttctaaa ataccaaaca gagaatttat gtaccaacat
      181 attgatgact gtatttcgaa aaatatacat ataggaatca tgttattaaa tatcgataac
      241 tttaaattat ttaatgatat atatggatac ctagtcggag aaaatttatt aattactcta
      301 actcaaaacc tattgcactt tattccagaa tcaaagggaa tagtcgctta tttaaaagga
      361 gaaggttttt taattgtact tccaaatgta tcaaataaag agttaaataa tatgggtgca
      421 actattatag agagcgcccg agaattaaaa ataaaacttc ctaatgaaaa agaaatatac
      481 tccaatgtta catttagtat cggcagcact atctggaatg gtgaaccaaa catgactact
      541 ttgatgcttt tcaaccaagt atatagtgct ttaaaaaagg ctaaaagtga aggtaaaaat
      601 agatacattc tatttgattt taaagataat agtttttaca ataaattaga aaatgataag
      661 gagttcttat cagaaatatc acatgttcta caaactaaac aaattgaagt attttaccaa
      721 ccactttata atataaaaaa taatactata gttggatgtg aggcacttgc aagatggaga
      781 caccctatta aaggacttct tactccagat aaatttattc ctttatttga acagtttggt
      841 ctgataacgg aattagattt gcatttattt gaagagaact gtaaaaatat aagaagatgg
      901 attgataaca atgatgtttt tgttccaatt tgttgtaact tttctcgtct tcattttttt
      961 aaccctaatt ttccaagtat gctaaaaggt attactgaaa agtacagcgt ctctacatca
     1021 aattttagca ttgaaataac agaaaatata ttaatagaaa atacaaatac aattattcaa
     1081 caactagctg aacttcgttc ttatggtttt tctgtatcaa tggacgattt tggttctgga
     1141 tattcatctt ttggtatgtt gcaaaatcta ccttttgata taatcaaaat tgataggata
     1201 tttttatctc ataatttaaa tgattttaaa aatacaacca ttttgtactc tataataaac
     1261 attgcaagag ctcttgggat gcttacagta tgtgaaggtg ttgaaacaga acaacatgta
     1321 gaatttatta aaagtataaa ttgtgatatc gcccaaggtt attattatgc aaaacccatg
     1381 gagtgcaaag aatttgaaaa attactatct aaagagaata attcagagaa aatgtttata
     1441 aaatattctg atataggaaa atctttaata gagaagatat ttgatggatt ttttattatg
     1501 caagatatga aaaaactaag agctaatgtc actgaagaca ttcaatggtt tgatttttac
     1561 aacaaaactg aaattacatc ttttcctaaa gtaatagagc attttgaaaa acatattaaa
     1621 ggtaaaaaat tttctattct ttacaaaagt ataaccccac ataatactga atcagattca
     1681 ttattaatta gtggagaagc cgttttatca gatgaagctt ctgaacatca aaaatatagc
     1741 aatttctact ttagtgcaaa ttgtataatt tcagaaaata aattactctt agcaaaatta
     1801 catttggatt taattaaaac tgctggctat ataaatgaat ttgaatcata ttcaatacct
     1861 aaaatgacaa atacacatct tgatgaaagt aatattttat cacaatttta ttcaatgttg
     1921 cctgtaggta taattcgcta cgatttattt ggtgatatga ttattactta tatgaatgaa
     1981 gaaatgtttg atattatagg ttatacaaaa gaacagtttt ttggtgagat gggcggaaat
     2041 ttaagagcaa ttgttcatcc agatgattta gactttgttt ataaaaaaag tttggatatg
     2101 attgacacaa ataaaattga accattttta tatagattca taaaacgaga tggtcaaatt
     2161 gtcacagtta tgtatacaca atgtaacctt tctgcaattg atggaaggtc gattgcccag
     2221 ggtatgtatg tagatgtaaa taaaataaaa aatttaacaa aaatctagta caaagtattt
     2281 tattttggag aaattaatat gtttaaagaa atttttttaa gaacttttcc aggatttcta
     2341 attataagag attctaacta cagaattata tttataaatg ataatttaaa aaatttaatt
     2401 aaaagttata tgcaagataa tccacttgga atgactaata tagaaatagc taagaaactc
     2461 cctgataata ttgctaaatt ttttacggat tctcacaata ttcaattaga ttgggaaaaa
     2521 aattatcctt atgataaaat ttcaaattgg attttagagt ttaaaaaaga tactacaagc
     2581 tattggaatg ttttagaata taaagtagat gttgatgaaa aaacctacat aattactatg
     2641 gccaatgata taacaaaact ctatgaagaa aataagagaa atcttcacta ctcaattact
     2701 gacccattaa ctggagcata taatagaaaa tatttaaatg atagatttga catatttata
     2761 ggagattata ttgtactaat tgacttagat aatttcaaaa tgataaatga ctatgaaggt
     2821 cataatgtag gagacaagat tttatgtgat tttgtttcac ttttaaataa agaattaata
     2881 aattctactt ctattataag attaggagga gatgaattta ttgttatatt ctctagtgat
     2941 gttgacaaaa attatgttta ttcacaacta gaagccttaa gagaaaattt tttaaaagta
     3001 ttctctaagt ataagtatct ttcatttagt tatggtgttg atacagtaaa aagaaattta
     3061 aaattgacaa tagttgaatt ggataaaaaa atgtataaaa acaagaaaaa atttgataaa
     3121 aatgattatt aatattgtta ttttaaaata aattaaaatt atctttcttt ttttaaactt
     3181 gtacattagt ttataaatat gtatctatac aagatattga cattaagtac tgaagcatat
     3241 attgtttcag ttcttttttg ttaaaattaa cttatttaac aaagatatca tagtttaaca
     3301 aagcttttaa tttaaatata ttgatgtata atataattaa aatataatag caaaaagaaa
     3361 ggaggaatat catgagcata ctcctaaaaa aagcacccaa attagcaaaa catattataa
     3421 caagttttta tataaatcgg gatattgatg aagtattaaa atacctttgt gaaaatgtta
     3481 catggatcgg accaggagaa caggaatttc tcacttcttt taatgaaata aaaaattatt
     3541 tttatgcagg tcaagatgaa attccttctt gtgatataaa taatgatata tttgaaactg
     3601 taagtgaaga tgagaataga tgtatggtat taggaagata tactgttcga actaaagaaa
     3661 atactcaaat gattttagag gtaaatcaac gttgtacatt tgagataatt gaggatagag
     3721 gaaaattatt agtaaagcac atgcacatat caaaccctta tggtgaaatg caacttgatg
     3781 aatactttcc cactaaaatt ggaactcaaa gttatgatta tttgcaaaga ttactaaagg
     3841 aaaaaacaga agttattgaa atgattacaa ataatatcaa tggtggctta aaaggtagca
     3901 atgatgataa tacatactca tttttctatg tcaatgaagg attgcccaaa atattaggat
     3961 acacatatga tgagttcatg gaaatgagtg gtggttcagc agtgggtgct gtatatccac
     4021 cagacttacc taaagcacta gaagattgtg aacgatgttt tgcaaaagga cctacatatt
     4081 catctgaata tagaatccga aaaaaagatg gaacattaat gtgggtatta gattctggaa
     4141 tgaaatcatt aaatagtgat ggcatagtaa aaattaatag tattattact gacataaccc
     4201 aactaaaaaa catagaatct gaactaaaat tagaaagaga gcgatatcgt attgctttgc
     4261 aaaatattac agatatcatg tttgagtatg atattgaaaa cgataccctt ataaaatatc
     4321 aacgtgtaga aattgacaaa aaaattgaat tagaaaattt tgaaacaaaa aattactcca
     4381 aactattaga atctggtaaa attattcacc ttgatgatat tggaaaacta ctagaagtac
     4441 ttcatggaaa tcttcgtgaa acaattgaga taagacaagt aaattcatta actaaaaatg
     4501 aatggagatg gattcgtgtt caatgttcag ttatatatga tagtgaccat aaccctatca
     4561 aaacaatagg cgttttaaaa gacataactg aagataaatc taaattagaa agcttaatta
     4621 atcaggctca acgtgaccca ctaacacaat tatataatca aagagtatca caaaatctta
     4681 ttgaagagta tctatgtagt tctgattcca aaaataatga tgctctatta gttattgata
     4741 ttgatgattt taaaactgta aatgatactt ttgggcattt agagggaaat gaagttttag
     4801 ttgctgtatc aaaaatacta ttacataaca cacatgataa agacatagtt gctcgaattg
     4861 gtggagatga atttacaata tttataaaat cattaacaaa ggatttaata ataaaaatta
     4921 ctaatgatat tttaaatgat gcaagtaaaa taaaagtaaa ggacaatcat aaaataacat
     4981 taagtattgg tattgccttc actgatgatt caactaaatt atataaagat ttattttcta
     5041 aagctgataa agctctttat ctatcaaaag cagatggcaa aaattgttat agtacatacg
     5101 aataataaag ctatttatac gaccaagaat gaacctttaa atttaatttc atagtctaac
     5161 aatcaaagag ttgaagctaa tcttatagct agtcaactag ttcctagaaa aaatttaaac
     5221 aatatattta ttgatactgc tcatttttct aaagagcaaa tttatataaa aaattaaact
     5281 tttatgtaca tacagatact aatgataaac agttatcatt agtatcttct atcttaaaac
     5341 aaaatgataa tttatctata taaaaaagtg ctttgttgac agagttcact tttttatata
     5401 ggtacagaat ttaagtataa atacatgttt tattctatac attttagtta atgtaaaatt
     5461 tcttgattgt actctctaac ttttcaacat tatactattt atataccact tagttaatat
     5521 aaacccctta gctggttcta gtgctttttc tatgatttta gtcatattta cataccactt
     5581 agttaatata aaacatattt tggatttatt aatataaaca taattaaaaa atttacatac
     5641 cacttagtta atataaaacc ccaaaataaa ctgggcattt tcaatactta cacatatgca
     5701 actctcttaa atttgcagtg aaccatgagt agtgcaaatg ataaagctta tcatataccc
     5761 tcaacacctt atatttcaag cgttaagctc tactttgtaa caaatatcgc tcactgcaaa
     5821 actatttaca tttttattat atcataaata tattattttt gaatatctat accaatttgt
     5881 ggtataataa aagcaagaag aactacaatc tatttagacg tagagtgaag ttcaaatact
     5941 aatgtttatt ctttttgaac ttgattttta gttcaaaact aaagtcactc ctgcctgtgt
     6001 gaactatacc cgctgtttta tacagttaaa acatgtaaaa atagttataa agtactagtg
     6061 taactcatta gtactctttt tattatattc atataattaa tatctatatt ttaaagttta
     6121 ctatctaaaa aagagcacgt caaataaaac cctagatatt taattttttt agagatactt
     6181 aaaataaatt atgctctctc tgtacttaaa tatttcctaa attcaaatgg agacatagaa
     6241 tttaatctat tttgatatct aaaattatta tagtagtata tataatcatc tattgcttta
     6301 actaattatt catatgtatc aaatttcctt aaatagtaca tttctacctt taaaattccc
     6361 caaaatcctt ccataggagc attgtcaagg caacgaccaa ctcttgtata atatatgtat
     6421 atctaacacc attaagaaat atatatttta taatatatat ttcttcattt aatgcactta
     6481 gaaaagcaaa gaaaatacag attagtacac tttttagaga aaaataaaat taatacatct
     6541 aaaatattaa aaaatacttt agataatcta aagacacatc tcaaagtttt taactaaatt
     6601 ataaaactaa ttacaaatgc tatgtaacga taataaataa aaaatttact tcgcttaagc
     6661 gacgtgtcgt tgaaatattt catgttgcca actggttcgt aagttgataa gaaaagaaca
     6721 ctaattattt agagttcttt tcttagctac aagtggatta taatactttt aaatctgtga
     6781 gaaaatcata tataataatg atatgaacaa gtaaagaaaa tacaaaaatg acaaaattat
     6841 aaataaaata ttataaaatc ataaggtcat aattgttata ttgtagaaac aaagtaaaga
     6901 gagagggtgg agaataaatg aatcaaaaaa aaataaagat tagtattaaa atggtaatta
     6961 taggtatatt tgctgtaatt attgcttttg tattatccag attattcgtt gagtatattg
     7021 atgaattatt aaggtctaat tggcaatatc agctatttga aagtgagagt tcatatatag
     7081 tatttgccaa ttgtattatg
//
LOCUS       DAEPID010000129         6923 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.130, whole genome shotgun sequence.
ACCESSION   DAEPID010000129 DAEPID010000000
VERSION     DAEPID010000129.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 6923)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6923)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..6923
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.130"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            complement(<1..490)
                     /locus_tag="KR257_003579"
     CDS             complement(<1..490)
                     /locus_tag="KR257_003579"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016056344.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0032235.1"
                     /translation="MAYENGTDFIDYFPDCIEKYKEDNKIFEKAILLLNLYMQKPTWP
                     HCVNEYKSQAEKILGEDPEFIGKYGIQLRKFYDEDENAKVSKEFKNDLYNFSKSTYDI
                     LDNVYFSKSHPFNLSSIYSTSRDDDFIIKIFRYDNNFLELEMSKREVESLINYLSDLL
                     KEE"
     gene            complement(740..1552)
                     /locus_tag="KR257_003580"
     CDS             complement(740..1552)
                     /locus_tag="KR257_003580"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018112536.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="N-acetylmuramoyl-L-alanine amidase"
                     /protein_id="HBH0032236.1"
                     /translation="MKICITVGHSILKSGACTSADGVVNEYQYNKSLAPVLADTFRKE
                     GHKVDVIICPEKQFKTKSEEKSYKIPRVNAGGYDLLIELHLNASDGQGKGSEVLYYSN
                     KGLEYATRICKKLGTIFKNRGAKLDKGLYILNSSKPTAILIESFFCDNKDDYEKAKKF
                     GYEGMAKLIVEGVLNKNIGNDGVKLMYKHTIVYDGEVDKIPATVVGWGYNDGKILICD
                     IKDYIPGQTENLYIVGGGACNKIGSITKEKYTMIKGNDRFDTLYKALDFIDR"
     gene            complement(1552..1809)
                     /locus_tag="KR257_003581"
     CDS             complement(1552..1809)
                     /locus_tag="KR257_003581"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889440.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phage holin family protein"
                     /protein_id="HBH0032237.1"
                     /translation="MDNLISFIPEQLLILVAALSIIGKGCKKYKQLDNKYIPVVLLIL
                     GIGFSIWMLGLSPVAVLQGVICWGISIGINQTYKQLKEENK"
     gene            complement(1829..2059)
                     /locus_tag="KR257_003582"
     CDS             complement(1829..2059)
                     /locus_tag="KR257_003582"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898415.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hemolysin XhlA family protein"
                     /protein_id="HBH0032238.1"
                     /translation="MNEELFKENLKRHEVTINKHNDEIDELKVANIESKAELKALCEN
                     LNSLTSMLKWLIGTMITTLVGFFIFAVQKGIF"
     gene            complement(2117..3682)
                     /locus_tag="KR257_003583"
     CDS             complement(2117..3682)
                     /locus_tag="KR257_003583"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430367.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0032239.1"
                     /translation="MATVYEFNYTGSEQSVTLKPGKYKFECWGARGGALGTPFESGFY
                     YGYGGYCSGEITLKKETTLYLYVGIDGRKGYNFNSAGYGNGASGGGATDIRLIGGTWD
                     NEQGLLSRIIVAGGGGGTYDKQHGGDGGGLKGTLGTSSTGAAAHGGTQFEGGRGRDKD
                     GSCDGFFGKGATPKNPSSQSGGGGGWFGGAYPASGFGNGSGGGSGYVLTKDSYKPPGY
                     TPTSEYYFDNVVMTTGGNTTVVGNYSDGRAKITLLQALPFLNISSYNSTTATFKADHT
                     DPTLLTKIEIFIDDILKETITTDLILEKTINYTLEDNALHTLKIVVTDSTNATAEKIV
                     SLSKNIMPLGDDASLQDIASKVSEIKEGLINGKTSIINVLALKNIESSLNNSLVELSE
                     KVKESFDSSDASLQDLINQLTQANNTISQLNSKYKYSSGTFTYYTGAYPNGLNIGFRP
                     DIISYTVINAVEEKYYCVYTPLFYLFYNYTTGEKYLDVNHNHYGITFTDNGWIPKGPV
                     NNGVYSYIAVKCC"
     gene            complement(3810..3947)
                     /locus_tag="KR257_003584"
     CDS             complement(3810..3947)
                     /locus_tag="KR257_003584"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898417.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="XkdX family protein"
                     /protein_id="HBH0032240.1"
                     /translation="MNWYKIITDFYNNGNWTKEQVKTAVEKNKITATEYKEIVGEDYI
                     A"
     gene            complement(3948..4247)
                     /locus_tag="KR257_003585"
     CDS             complement(3948..4247)
                     /locus_tag="KR257_003585"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898419.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0032241.1"
                     /translation="MIYLGNFMETDEQNIKYIGMIHYKPTLLSEEELKNGILIEKLPV
                     QQYVENKEAKLFINIDTKEVFYRYTDIKSSIEDKVNSTEQTIADLTFQLMSNGVI"
     gene            complement(4244..5479)
                     /locus_tag="KR257_003586"
     CDS             complement(4244..5479)
                     /locus_tag="KR257_003586"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898421.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0032242.1"
                     /translation="MTFKELVNKVRNLVLEAKNVTIEDTENNFTSDNVEGALKEVFQN
                     GVNAKNNVVTALNSKGAEVTTSDTWEEIKNKIDIKEGRLDLRETILANSYSSYLVTNG
                     AIKYIEKYSGSLKALEYEEPYFYAIKGTHLIKINAIDESVIFDITLANANFSCICVTQ
                     EYLFISDNTKLYKINKLTGNEAQSIEGSYYKLCTYGEFIYGIYGDETSSILHKIRISD
                     MYIMLTKDMSSDRIYDFERGKFVCNNNGIYATTEHSNSSGLTECYLTKINFDFSVAKS
                     FRIGGYLYEKNIKFLNDFVFVSDSSRSIEVESGKKSGLAKYDANLNLITYGGSDRYEN
                     FEIYNGYIYTFNSLSSSPFIKINLNTLKEVNSYRTLINTNPQKGMFIINNIIFFIGGG
                     IHRNILSKKVYSDEKGEEL"
     gene            complement(5513..5695)
                     /locus_tag="KR257_003587"
     CDS             complement(5513..5695)
                     /locus_tag="KR257_003587"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426796.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0032243.1"
                     /translation="MNINNVVVRILAERILNGGLNPLKNREFQLDDVTNTEYRKAVED
                     YIIKNSGVVEGIEPTA"
     gene            complement(5695..5907)
                     /locus_tag="KR257_003588"
     CDS             complement(5695..5907)
                     /locus_tag="KR257_003588"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0032244.1"
                     /translation="MKKQVYYNSLDEKEKIISENSNLYVIEIYETLNENYLVLSSSPI
                     QDEKLSYEELENELLIMTNELQGGLL"
     gene            complement(5917..6555)
                     /locus_tag="KR257_003589"
     CDS             complement(5917..6555)
                     /locus_tag="KR257_003589"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009901453.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0032245.1"
                     /translation="MTEKLTENASLGELMAALENVQTDFQTGKNNISSALGSPFIGTD
                     KFGTTKTKIETLKNVLVETINSKNVSATSSETFTNLIEKVNWIFQSIEIFSLKNRIQA
                     TTLNTPSIVYNEVSSIKGTLRFTGELKASKMRADYATAKIEILCGNRKEYFYVTDDTP
                     SASSSFVRFTKDIIVENGMDIKVQILLTSVGAGNLDGSYAARAEIEKLTILR"
     gene            complement(6569..>6923)
                     /locus_tag="KR257_003590"
     CDS             complement(6569..>6923)
                     /locus_tag="KR257_003590"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728465.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=2
                     /transl_table=11
                     /product="phage tail protein"
                     /protein_id="HBH0032246.1"
                     /translation="KENAVTNFKIIDDNSIEVRSETRSELNVYVINGNAETHFINATV
                     DDNRVSEMTTYSSKKIEDSISSIQLIDTSISITDANDRFTSDKLDGVLEEIMVEISGQ
                     RTKGITIVNNLIDMI"
BASE COUNT         2166 a         1265 c          725 g         2767 t
ORIGIN      
        1 attcttcctt taataaatca gataaatagt ttattaatga ctctacttct ctctttgaca
       61 tctctaattc aagaaaatta ttatcatatc taaatatttt tattataaaa tcatcatctc
      121 tagaagttga ataaatagat gaaagattaa aaggatgact ttttgaaaaa taaacattat
      181 ctagtatatc atatgtactc ttagaaaaat tatacaaatc atttttaaat tccttactta
      241 cttttgcatt ttcatcttca tcataaaatt ttcttaattg tataccatac tttcctataa
      301 actctgggtc ttcacctaaa attttttccg cctggctctt gtactcatta acacaatgtg
      361 gccatgttgg tttttgcata tacagattga gtaataatat tgccttctca aagattttat
      421 tatcttcctt atatttttct atacaatcag gaaaataatc tataaaatca gttccatttt
      481 cataagccat tttaaatccc cctaaaataa tattatttaa tattattcta cattagaatt
      541 attgttattg cactactatt ttttatttca cctccattat tttatcaata tatatatttg
      601 ttaactgttt atacacctag ttttttggat tttaaaatgg cttatgatta tctttaatat
      661 atcatttttt attttataaa ttgtcgtaat attggcataa agtataagca aaatgtaaaa
      721 tacattaact atactccttt tatctatcaa taaaatctaa tgctttgtaa agtgtatcaa
      781 atctatcatt accctttatc attgtgtatt tttctttggt tatagaacct atcttattac
      841 atgctcctcc acccacaata tataaatttt ctgtctgacc tggtatataa tcttttatat
      901 cacatatcag tatttttcca tcattataac cccagccaac tacagttgca gggattttgt
      961 caacttctcc atcataaacg attgtatgtt tgtacatcag tttaactcca tcatttccta
     1021 tattcttatt caatacacct tcaacaatta acttagccat accttcatat ccaaatttct
     1081 tagccttctc ataatcatct ttattgtcac aaaagaaact ttcaattagt attgcagtag
     1141 gttttgaact atttaaaata tataatcctt tatctaattt agcacctctg tttttaaata
     1201 ttgtacctag tttcttacat attctagttg catactctag acctttatta ctgtaatata
     1261 gaacctctga gccttttcct tgcccatcac ttgcatttaa atgtagttct atgagtaagt
     1321 catatcctcc agcattaact ctaggtattt tataagactt ttcctcactc ttagttttaa
     1381 actgcttttc tgggcatatt attacatcta ccttatgccc ttcttttcta aatgtatctg
     1441 ctaatactgg tgcaagagat ttgttgtatt gatactcgtt aactactcca tcagcagaag
     1501 tacatgctcc actttttaaa atactgtgtc ctactgttat acatattttc attatttatt
     1561 ttcctccttc aactgtttgt aagtttggtt tatacctatt gatatacccc aacaaatcac
     1621 gccttgtaag actgcaacag gacttagtcc taacatccaa atagaaaatc ctataccaag
     1681 tattaataac actactggaa tatatttgtt atctagttgc ttatacttct tacagccctt
     1741 acctataata gagagagcag ctactaaaat tagcaactgc tctggtatga aacttattaa
     1801 attatccatt ttttatcctc ctaattaatt aaaatattcc tttctgaact gcaaatataa
     1861 agaaccctac tagtgttgta atcattgttc caattagcca tttgagcata cttgtaagtg
     1921 agtttaaatt ctcacacaat gcttttaact ctgctttaga ctctatattt gccactttta
     1981 attcgtctat ttcatcatta tgtttattta ttgttacttc atgtcgtttc aaattttctt
     2041 tgaaaagttc ttcattcatg aaaacctcct tatttatatt aaaataaggc ttagaagtta
     2101 tctaagcctt tgataattaa caacatttaa ctgctatata actatacaca ccattgttaa
     2161 ctggaccttt aggtatccat ccattgtcag taaaagttat tccataatga ttatgattaa
     2221 catcaagata tttttctcca gttgtataat tataaaaaag atagaataaa ggtgtgtata
     2281 cacaataata tttttcttct acagcattga taacagtgta tgaaataata tctggcctaa
     2341 aacctatatt tagcccatta ggatacgcac cagtataata agtaaaagtt ccactagaat
     2401 atttatattt agagtttaac tgtgatatag tattattagc ctgtgttaac tggtttatta
     2461 aatcctgcaa actagcatct gaactatcaa aggattcttt taccttctct gacaattcta
     2521 ctaaagaatt gttcaaactt gattcaatat tctttaatgc taatacattt atgatagaag
     2581 ttttgccatt tattaatcct tcttttattt cactaacttt acttgctata tcttgtagac
     2641 tggcatcatc acctaatggc attatattct tacttagact tactattttt tctgctgtag
     2701 cattagtact gtctgtaaca actattttaa gagtgtgtag tgcattatct tctaatgtgt
     2761 agttaattgt tttttcaaga attaaatctg ttgtaatagt ttcttttaat atatcatcta
     2821 taaatatttc tatttttgtt agtagtgtag ggtctgtgtg gtctgctttg aatgttgctg
     2881 tagttgagtt gtatgaggat atattcaaaa atggtaatgc ttgtaataat gttattttag
     2941 cacgaccatc tgagtaattg cctacaacag tagtatttcc accagttgtc atgactacat
     3001 tatcaaaata atattcagaa gttggtgtat atccaggtgg cttataacta tctttagtta
     3061 gtacataacc acttccaccg ccacttccat taccaaatcc actagcagga taagcaccac
     3121 caaaccaacc accgccacca ccagattgtg atgaagggtt tttaggagta gcacctttac
     3181 caaaaaaacc atcacaagaa ccatctttgt ctctacctcg cccaccctca aattgtgtac
     3241 caccatgagc agcagcacca gtagaagaag ttccaagagt ccctttcaag ccaccaccat
     3301 caccaccatg ttgtttatca taagttccac cgccaccacc tgcaacaatt atacgagata
     3361 gtaaaccttg ttcattatcc caagtaccac caataagcct aatatcggta gcaccaccac
     3421 cacttgcacc attaccatat ccagcactat tgaaattata accttttcta ccatctattc
     3481 caacataaag atataaagta gtttcttttt ttaatgttat ttcaccacta caatatccac
     3541 cataaccata ataaaaacca ctttcgaaag gagttcctaa tgcaccaccc ctagcacccc
     3601 aacattcaaa tttgtattta cctggtttca atgtaacact ttgttcactt cccgtataat
     3661 taaattcata aactgttgcc acttaatcca cctctttctt aatttatggt tttattgtac
     3721 ctaattttaa aactacaaac gtctacaaag tgtagatgaa gtgtaggcaa aatgtaaatg
     3781 aatttatata ttttaagaaa taaaaaagac tatgctatat agtcctctcc tacaatttct
     3841 ttatattctg ttgccgttat cttattcttt tctactgccg ttttaacttg ctctttagtc
     3901 caattaccat tattatagaa atctgttatt atcttgtacc aattcattta tatcacccca
     3961 tttgacatta attgaaatgt taaatctgct attgtttgtt ctgtagaatt tactttatct
     4021 tctatgctac ttttaatatc tgtatatcta tagaaaacct ctttagtatc tatatttata
     4081 aataactttg cttctttatt ttctacatat tgttgtactg gcaatttctc aattaaaatt
     4141 ccatttttta actcttcttc tgatagtaaa gttggtttat agtgtatcat cccaatatat
     4201 tttatatttt gttcatctgt ctccataaaa tttcctaaat aaatcataat tcctctcctt
     4261 tttcatctga ataaaccttt tttgataata tatttctgtg aatgccacca ccaataaaaa
     4321 aaattatatt gtttattata aacatacctt tttgaggatt tgtgttaatg agcgttcggt
     4381 agctattaac ttctttaaga gtatttaaat ttatttttat aaatgggcta ctagaaagtg
     4441 aattaaatgt atatatatat ccattatata tttcaaaatt ttcatatcta tctgacccac
     4501 cataagtaat caaatttaga tttgcatcat attttgctaa tccacttttt ttaccactct
     4561 caacttctat gcttctgcta ctatcagata caaaaacaaa atcatttaaa aacttaatgt
     4621 ttttttcata taaatatcct ccaattctaa aacttttcgc aacactaaaa tcaaaattta
     4681 ttttagttag gtaacattct gtaagaccac ttgaatttga gtgttctgtt gtagcataaa
     4741 taccattatt attacataca aatttgcctc tttcaaagtc ataaattcta tcagaggaca
     4801 tatctttagt tagcattata tacatatccg atattcttat tttgtgaagt attgaagaag
     4861 tctcatctcc atatattcca taaataaatt ccccataagt acatagctta taataagaac
     4921 cttctattga ctgtgcttca tttcctgtta acttatttat tttatataat ttagtattgt
     4981 cagatataaa taaatactct tgagtaacac agatacatga gaagttagca ttggctaaag
     5041 taatatcaaa aattacagat tcatcaattg cattaatttt aattaaatgt gtacctttaa
     5101 ttgcataaaa atagggttct tcatattcta atgcttttaa actcccacta tatttttcaa
     5161 tatattttat agcaccattt gtaaccaaat atgaagaata actatttgca agtattgttt
     5221 ctcttaaatc taatctcccc tcttttatat caattttatt ctttatttct tcccatgtat
     5281 cgcttgtagt aacctctgct cccttggagt ttaatgctgt tactacatta tttttagcat
     5341 taactccatt ttgaaaaacc tcttttaatg ctccttctac attatcactt gtaaagttat
     5401 tctctgtatc ttctatagtt acattctttg cttctaatac aagatttcta actttattaa
     5461 ctaactcttt aaaagtcatt tagtcacctt ctttcaataa aaaaagaacc tactacgctg
     5521 ttggttctat tccttctact actccactat tttttataat ataatcctct actgcttttc
     5581 tgtattctgt gttagttaca tcatcaagtt gaaactctct atttttcaaa gggtttaacc
     5641 ctccatttaa tattctttct gctaatattc ttaccacaac attatttata ttcattataa
     5701 caatcctcct tgtaattcat tagtcataat taataattca ttttctaatt cttcataact
     5761 aagtttttca tcttgtattg gactacttga taacactaaa taattttcat ttaaagtttc
     5821 atatatttct ataacatata aattagagtt ttcactaatt attttttctt tttcatctaa
     5881 agaattataa tatacttgtt ttttcataat ttattcctac cttaatattg ttaatttttc
     5941 tatttctgca cgagctgcat atgaaccatc taaatttcct gctcctacag atgttaataa
     6001 tatttgtact tttatatcca tgccattctc aacaataata tcttttgtaa atcttacaaa
     6061 agaagaagat gcactaggag tatcgtcagt aacataaaag tattcttttc ggtttccaca
     6121 tagtatctct atttttgctg ttgcataatc agcacgcatt ttagacgctt taagttcgcc
     6181 tgtgaatctt aatgtgcctt ttatactaga tacttcattg taaacgatgc taggagtgtt
     6241 taaagttgta gcttgaattc tattttttaa agaaaaaatt tctattgatt gaaaaatcca
     6301 gttaactttt tcaatcaaat tagtaaatgt ttcagatgat gttgctgaaa catttttaga
     6361 attaatcgtc tccactaata cattttttaa tgtttctatt tttgttttag ttgtaccaaa
     6421 tttatctgtt ccaataaaag gactacccaa tgcactagat atattatttt taccagtttg
     6481 aaaatcagtt tgtacatttt ctaatgctgc cataagttcc cctaaactag cattttcagt
     6541 taatttttct gtcatatttt cacctcgctt atatcatatc tattaaatta ttcactatag
     6601 ttattccttt agttctttga ccacttattt ctaccattat ttcctctaat actccatcta
     6661 acttatcact tgtaaatcta tcattagcat ctgtaatact tatactggta tctataagct
     6721 gtatactgct aatagaatcc tctattttct tagatgaata agtagtcatt tcagacactc
     6781 tgttatcatc tacagttgca ttaataaaat gagtttctgc atttccattt atcacataaa
     6841 cgtttaattc tgaccttgtt tcacttctaa cttctataga attatcatct ataattttaa
     6901 agtttgtaac tgcattttct ttt
//
LOCUS       DAEPID010000130         6921 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.131, whole genome shotgun sequence.
ACCESSION   DAEPID010000130 DAEPID010000000
VERSION     DAEPID010000130.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 6921)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6921)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..6921
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.131"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            134..1915
                     /locus_tag="KR257_003591"
     CDS             134..1915
                     /locus_tag="KR257_003591"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438344.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="UvrD-helicase domain-containing protein"
                     /protein_id="HBH0032247.1"
                     /translation="MSQYININSQLDALKLKEFEKIFYENINEDVKVVPKVTPFKGIN
                     TDLLYVKDGRILFIKFMDTTEDIFFILEEELLEVMNEEYELLKLKMGQKNRNISYNYV
                     YIMPYVEVEETYEFEEFVNNNIIDKNKLQDIMNKGSLEEYLNDENDEINLNLFLLDIC
                     SEYYIINDKLHLNEKFKKISFYNDDYKYTATMMEDVQIKDVVSIKYGNTLIEGGSGIG
                     KTAIMLSRAIKLAKVYPHHKLVIFTHTKQLCNELRERIELLYKDNNNLEVHTFSSFIF
                     KLAKKFNLIVDYNMLKNDYEKTFNNLVKQAQNIIKNKNMFKAIFIDEAESFLEYEIDF
                     IREFLYKTKFIFNVCSCNSLNISNRLNIFKKLYNGIEFDDKIILSKNYRQAKEIVDFT
                     NKFSNNSNSYINELRPNTEFSTFFYTKALRGGNKSVDIIKVSDLDDQISSVIWEIEYL
                     ISKKGLDYSEVAIVYPYNKKKLKSGKTIYFQYMLKKALEEAKIPYICAEDNLTNISKK
                     VGTTIANIYAIKNLEYKAVIVCELEMLYNQTINDIEQDYQVNDFVGDLNKVYLAMSRA
                     TDYLSIVTTFNEEASDIIRLITESKDI"
     gene            complement(1997..2527)
                     /gene="lepB"
                     /locus_tag="KR257_003592"
     CDS             complement(1997..2527)
                     /gene="lepB"
                     /locus_tag="KR257_003592"
                     /EC_number="3.4.21.89"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729595.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="signal peptidase I"
                     /protein_id="HBH0032248.1"
                     /translation="MSVKKEIFDWIKSIAMAIVLAFVILQFIRPSIVSGESMYPTLDD
                     KDYLILNRISYKVGKPEKGDIVVFKTNLVDGETGKKKDLIKRVIATEGDRIKISNSKV
                     YVNGKLLNEPYIHNNYTSGDIDTVVPKGKLFAMGDNRENSNDSRFPDVGMVDEDEVLG
                     KVMVRLLPLDNIGKVD"
     gene            complement(2567..3391)
                     /locus_tag="KR257_003593"
     CDS             complement(2567..3391)
                     /locus_tag="KR257_003593"
                     /EC_number="3.6.1.27"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438350.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="undecaprenyl-diphosphate phosphatase"
                     /protein_id="HBH0032249.1"
                     /translation="METFSLLEIFKAVILGIVQGITEWLPVSSTGHMILVDEFIKLNF
                     SNTFISTFLVVIQFGSILAVLVIFFRKLNPFDSAKNIKQKKETVRLWLKVIIAVIPSG
                     VIGILFEDDIDRLFFNSTVVAIALIVYGIIMIGLEKRNKKPKYKDFSQVTYKLALCIG
                     LFQCLALIPGTSRSGSTIIGAVLLGTSRYVAAEFSFFLAIPTMLGASALKLLKAGFGF
                     TGFEWLILGVGSVVAFVVSIVVIKFFMDYIKKHDFKVFGYYRIVLGIVVLAYFFLL"
     gene            3648..4556
                     /locus_tag="KR257_003594"
     CDS             3648..4556
                     /locus_tag="KR257_003594"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889110.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tyrosine-type recombinase/integrase"
                     /protein_id="HBH0032250.1"
                     /translation="MYSTKILDDYEYETFNVFSTKLNPNTKHDYLSKVILFKEFLKGK
                     ELIYATKEDCKNFVDYIQTKYAKSTCEKIYSYLHSFYNFLKKEGYIDINPFRYVEKPT
                     VTRIKTKDDVLSIQEINKLIGILPKLNIRDRVIIVCLVTTGCLLNELVSLKWKDLMVD
                     ENDNSYVRLGKGRKERVVKLHPYFFKLLEDYRNYSGLPEVIIPSDDFIFTTQKSNSIT
                     DRNVRLIVKKALDLAGLSQYSARDFRHSFAAISLRLGADESDVKNQLGWSDKYYAIRY
                     KYVLNFVDSEIVDYLIEKDNLDINKK"
     gene            4700..6145
                     /locus_tag="KR257_003595"
     CDS             4700..6145
                     /locus_tag="KR257_003595"
                     /EC_number="4.3.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419557.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="adenylosuccinate lyase"
                     /protein_id="HBH0032251.1"
                     /translation="MIDNKYTTYSNPLTDRYCSKDMSYIFSPQFKFSTWRRLWVALAE
                     GEHELGINITEEQLDELRANIDNINFDEARKIEKEVRHDVMSHVKAYGLQCEKAKGII
                     HLGATSAYVGDNTDVIQMNEALKLLRVKLVNLINNLKEFALKYKDMPALGFTHFQAAQ
                     LTTVGKRACLWAQDLILDLEDLNYRIDNMKLRGVKGTTGTQASFLSLFEGDHEKVKEL
                     DKKICKKMGYHSSYAVSGQTYTRKLDYQVISILSGIAQSMHKMTNDIRLLQSLKELEE
                     PFEKNQIGSSAMAYKRNPMRSERIASLSKYIISESISPAMVQATQWLERTLDDSANKR
                     LAIPQAFMAADAILEIGINVTDGLVVYENMINRRVNEELPFMATETILMEAVKRGGDR
                     QELHEIIREYSMKAAYRVKHEGKDNNLIELIMNDDSFKMSKEEILSIMDPKNFIGRAP
                     EQVVEFVNEVVEPAIKDYKEDLGKVDVDLRV"
     gene            6456..6908
                     /locus_tag="KR257_003596"
     CDS             6456..6908
                     /locus_tag="KR257_003596"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428210.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MarR family transcriptional regulator"
                     /protein_id="HBH0032252.1"
                     /translation="MNYIVKDTISFLVKTFPKIYSSLYLEDLKKFAPDYNVNKTQLRA
                     LVFIKNYGVISMTDLCSKLNIEKGSLTSMVDDLTDKKYVTRKRDLVDRRKYLIDITEE
                     GDKIATDFMDKLSDGLGEKLSKLTEEDRKKYLEAINTLQYILNKEEFR"
BASE COUNT         2846 a          827 c         1041 g         2207 t
ORIGIN      
        1 caaaattttt ttagcagttt tgtatttatt tgtatttatt ttgaatttat ttactaaatt
       61 tgcctataaa aagtatatat aaaaatatag ttcaaaatgg tataattaag tataacagaa
      121 ggaggtaatg taagtgagcc aatacataaa tataaattct cagttagacg ccctaaaatt
      181 gaaggagttc gagaaaatat tttacgaaaa tatcaatgag gacgttaaag tagtgccaaa
      241 agttactcct tttaaaggaa taaataccga tttgttgtat gttaaagatg gaagaatttt
      301 atttataaaa tttatggata caacagaaga tatatttttt attttagaag aagagttact
      361 tgaagttatg aatgaggaat atgaactttt gaaactaaaa atgggacaaa agaatagaaa
      421 tataagttat aactacgttt acattatgcc atacgttgaa gttgaggaaa catatgaatt
      481 tgaagaattt gttaataata atataataga taaaaataag cttcaagata taatgaataa
      541 gggttcgctg gaggaatatc ttaatgatga gaatgatgaa ataaacttaa atttattttt
      601 actagacata tgttcagaat actatataat aaatgataaa cttcatctaa atgaaaaatt
      661 taaaaaaatt tcattctaca atgatgacta taagtataca gcaactatga tggaagacgt
      721 tcaaattaaa gatgttgttt ctattaaata tgggaataca cttattgaag gtggttctgg
      781 tataggcaaa acagcaatta tgctttctag ggctataaaa ttagcaaaag tatatccaca
      841 tcataaatta gtcatattta cacatacaaa acaattgtgc aatgagcttc gagagaggat
      901 agagttatta tacaaagata ataacaattt agaagttcac acatttagtt cttttatatt
      961 taaactagct aaaaaattca atttaattgt agattataac atgttaaaaa atgattacga
     1021 aaagaccttt aataatcttg taaaacaagc acagaacatt ataaaaaata aaaatatgtt
     1081 caaggctatt tttattgatg aagcagaaag ctttttagag tatgaaatag attttataag
     1141 ggagttttta tataaaacaa aattcatatt taatgtgtgt tcttgtaact ccttgaatat
     1201 ctctaataga ttgaatatat ttaaaaaatt atataatggt atagaatttg atgataagat
     1261 tatcttaagt aaaaattata gacaagctaa agagattgta gattttacaa ataaattttc
     1321 aaataattct aactcatata tcaacgaatt aagaccaaat acagaattta gtactttctt
     1381 ttatactaaa gcacttagag gtggaaataa gtctgttgat ataataaaag taagtgacct
     1441 tgatgaccaa ataagttctg taatctggga aattgagtat ttaataagta aaaaaggtct
     1501 tgattattct gaagttgcta tcgtttatcc ttacaataag aagaaattaa aaagtggaaa
     1561 aaccatttac tttcaatata tgttaaaaaa agcattggaa gaggcaaaaa ttccttatat
     1621 atgtgcagaa gataatttga caaatataag taagaaggta ggaactacaa tagcaaatat
     1681 atatgcaata aagaatttag agtataaagc ggtaatagta tgtgaattag agatgttata
     1741 caatcaaact ataaatgata ttgaacaaga ttatcaagta aatgactttg taggagattt
     1801 aaataaggtt tatttagcta tgagtagagc aacagactac ctaagtatag taacaacttt
     1861 taatgaagaa gcaagtgata taataagact tattacagaa tcaaaagata tttagtaaaa
     1921 aaatatttgt aatttaagaa aataaaaaga gactgagatt tgtaaaataa actttaccaa
     1981 ttcagtctct tattttttag tctactttcc caatattatc aagaggtaat agtctcacca
     2041 taaccttacc aagaacttca tcttcatcaa ccatacctac atcagggaat ctactatcat
     2101 tactattttc tctattatct cccattgcaa atagtttacc ttttggaaca acagtatcta
     2161 tatctccaga agtatagtta ttgtgtatat atggttcatt taataatttt ccatttacat
     2221 acactttaga atttgatatt tttattctgt caccttcagt agctataact ctttttatta
     2281 agtctttttt ctttcctgtt tctccatcaa ctaaattggt tttaaaaact acaatatcgc
     2341 ctttttcagg tttaccaacc ttgtatgata tcctatttaa aatcagataa tctttatcat
     2401 ctaaagtagg atacattgat tctccactta caatagaagg tcttataaat tgtagaatta
     2461 caaatgcaag tacaatagcc atagctattg acttaatcca atcaaatatt tcttttttaa
     2521 cactcataac ttttctcctt atcatttgtt attaaattag aatacattat aatagaaaga
     2581 aataagcaag aaccactata cccaagacta ttctataata accaaatact ttgaagtcat
     2641 gttttttgat atagtccata aaaaatttaa taactacaat tgaaacaaca aatgctacta
     2701 cagaaccaac acctaaaata agccattcaa atccagtaaa tccaaatcca gcttttagaa
     2761 gttttaatgc actagctcca agcattgtag ggatggctaa gaagaatgaa aactctgctg
     2821 ctacatatct agaagtacca agtaatactg cacctattat agtagaacca gacctagatg
     2881 tacctggtat aagagctaga cactggaata atcctataca aagagctaat ttatatgtaa
     2941 cttgagaaaa atctttatac ttaggttttt tatttctctt ttcaagccct atcattatta
     3001 taccatatac aataagagca atagcaacta ctgttgaatt aaagaataat ctatctatat
     3061 catcttcaaa cagtattcca ataactccag atggtataac tgcaattata accttaagcc
     3121 ataaacggac tgtttctttt ttctgcttaa tattctttgc gctatcaaaa ggatttaatt
     3181 ttctaaaaaa tataacaagt acagctaata ttgaaccaaa ttgaattaca actaaaaatg
     3241 tacttataaa tgtatttgaa aaattcaatt ttataaactc atcaactaat atcatatgcc
     3301 ctgtactact tactggtagc cattctgtta ttccctgaac tatgcccaaa atgactgcct
     3361 taaaaatttc aagcaaacta aatgtttcca aatcaaaata cctccaatac aaatttatag
     3421 tagcatattt tattcataga ttaataaaaa aatgccacct tttactaact tataatacca
     3481 tagtactgtg tagtgcacaa tggaagattg atattttcat aaaaccttca caatataaca
     3541 aaataaactt aaaagttatc tattgaataa ggggtatatt tgagggggaa atatatggta
     3601 tagtaaaagt atagctattt tattttatga aaaggaaagg agttattatg tatagtacaa
     3661 aaatactaga tgattatgag tatgaaactt ttaatgtttt ttctacaaaa ttaaatccaa
     3721 acacgaaaca cgattattta tcaaaggtta tactgtttaa agaattttta aaagggaaag
     3781 aattgattta tgctacgaaa gaagattgta aaaattttgt agactatata cagactaaat
     3841 atgcgaaatc aacttgtgaa aagatatata gttatttaca tagtttttat aacttcttaa
     3901 aaaaagaagg atacatagat ataaatccat ttagatatgt agaaaaaccc acagtaacaa
     3961 gaataaaaac aaaagatgat gttctaagta tacaagaaat aaataaactt ataggtatcc
     4021 taccaaaatt aaatataaga gatagagtaa taatagtctg tctagttact actgggtgtt
     4081 tattaaatga attagttagc ttaaagtgga aagaccttat ggtagatgaa aacgataact
     4141 catatgtaag gttaggtaag ggaagaaaag aaagagtagt taaattacat ccatactttt
     4201 ttaaactttt agaagattac aggaattatt ctgggcttcc agaggtaata atacctagtg
     4261 atgattttat ttttacaact caaaagagta attctataac agatagaaat gtcagactta
     4321 tagtcaaaaa agcattagat ttagctggac tttctcaata ttcagcaaga gattttagac
     4381 attcatttgc agcaataagt ttaaggcttg gggcagatga aagtgatgta aaaaatcagc
     4441 ttggatggag tgataaatac tatgcaatta gatataagta tgtattaaat tttgttgata
     4501 gtgaaatagt ggattactta attgaaaaag ataatttgga tataaataaa aaatagtaat
     4561 aaataaaaaa tactatatat aaatgtgaac aaaaaataaa aaagtcttgt tatagttcgt
     4621 aaaattatat ataattattt atgtactaat gtgtacacag taatcacacg acaaaagatt
     4681 taaggaaggt gctaatataa tgatagataa taaatatact acttactcaa acccacttac
     4741 agacagatat tgtagcaagg acatgagtta tatattttct ccacaattta aattctctac
     4801 atggagaagg ttatgggttg cacttgcaga aggtgaacat gagttaggaa tcaatataac
     4861 tgaagaacaa ttagatgagc taagagctaa tatagataat ataaattttg atgaagctag
     4921 aaaaatagaa aaagaagtaa gacatgatgt aatgtctcac gtaaaagctt atggtttaca
     4981 atgtgaaaaa gccaaaggaa taatacattt aggagcaaca tctgcatatg ttggagataa
     5041 tacagatgtt atacaaatga atgaagcttt aaaacttcta agagtaaagc ttgtaaattt
     5101 aataaacaat ttaaaagaat ttgcacttaa gtacaaagat atgccagctc ttggatttac
     5161 acacttccaa gctgctcaac ttacaacagt aggaaaaaga gcttgtttat gggctcaaga
     5221 tttaattctt gatttggaag atttaaacta tagaatagac aacatgaagt taagaggagt
     5281 taaaggtact actggtactc aagcaagttt tttaagctta tttgaaggag accacgaaaa
     5341 agtaaaagag ttagataaga aaatttgtaa aaagatggga taccattctt cctatgcagt
     5401 aagtggacag acatatacta gaaagttaga ttatcaagta ataagcatac tatcagggat
     5461 agctcaaagt atgcataaga tgactaatga tataagactt ttacaaagtt taaaagaatt
     5521 agaagagcca tttgaaaaaa atcaaatagg ttcatcagca atggcttata agaggaatcc
     5581 aatgagaagt gagagaatag catctttatc taagtatata atctctgaat ctataagccc
     5641 tgcaatggta caagccactc aatggttaga gagaacatta gatgactcag ccaataagag
     5701 attggcaata cctcaagcat ttatggcagc agatgctata cttgaaatag ggataaatgt
     5761 aactgatggt ttagtagtat atgaaaatat gataaataga cgtgtaaatg aagaacttcc
     5821 ttttatggct acagaaacaa tacttatgga agctgtaaaa agaggtggag atagacagga
     5881 attacatgaa ataataagag aatattctat gaaagctgcc tatagagtaa agcatgaagg
     5941 caaggataat aacttaattg aacttataat gaatgatgat tcatttaaaa tgagcaagga
     6001 agaaatacta tctataatgg acccaaaaaa ctttataggt agagctccag aacaagttgt
     6061 agaatttgta aatgaagttg tagaacctgc tataaaagat tataaggaag acttaggaaa
     6121 agtagatgta gacttaagag tatagaattg tacagataaa atataattaa aaacggctat
     6181 cttatttata aataagatag ccattttaat gggctagcgt cttctctcca ccgctgtgaa
     6241 gagttcttct ttacttacta taccatgaat ttaataaaat agctatataa ataatattta
     6301 ataggaataa tataaataaa aataaaaaaa tgataagatt actaattaaa tttaaacatt
     6361 cagcaaaaac tattgtactt gcaatatttt taatgtaaac tgaaataaag ttatttagat
     6421 aatttaataa attttaaaac aaccgaggtg attatatgaa ctatatagta aaagatacca
     6481 taagtttttt agtaaaaaca tttcctaaga tttattctag cctgtactta gaagacctaa
     6541 aaaaatttgc accagattat aatgtaaata aaacacaatt aagagcatta gttttcataa
     6601 aaaattatgg agtaataagt atgactgatt tatgctctaa gttaaatata gaaaaaggca
     6661 gtttaactag tatggttgat gatttaactg ataagaagta tgtaacaagg aaaagagatt
     6721 tagttgatag aagaaaatat ctaattgaca ttactgaaga gggagataag atagcaactg
     6781 attttatgga taaattaagt gatggtttag gagaaaaact ttctaaatta actgaagaag
     6841 acagaaaaaa atatttagaa gcaataaata ctcttcaata tatattaaac aaagaagaat
     6901 ttagatagaa aaaatataaa a
//
LOCUS       DAEPID010000131         6874 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.132, whole genome shotgun sequence.
ACCESSION   DAEPID010000131 DAEPID010000000
VERSION     DAEPID010000131.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 6874)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6874)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..6874
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.132"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            19..1275
                     /locus_tag="KR257_003597"
     CDS             19..1275
                     /locus_tag="KR257_003597"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003362983.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase family 2 protein"
                     /protein_id="HBH0032253.1"
                     /translation="MRDLNVSEYLFVFSLFSIWSLLLINIILAMGGYIFYFKNFDKEI
                     KEIDEYPMISILVPAHNEAKVIGRTVESLLLLNYPKSKMELIVINDNSSDNSKEILEN
                     IKDRYNNYNFTIINTDSLTGGKGKSNALNIGYTISKGDFIAVYDADNTPDKNALRYLV
                     QTIVMNDELGAVIGKFRTRNKNKNLLTKFINIETLSFQWMSQAGRWQLFNLCTIPGTN
                     FILRRSIIEEIGGWDSKAIAEDTEISFRIYKLGYKIKLVPQSITWEQEPETVKVWIKQ
                     RTRWAKGNIYVLMKYIKNIFKQGRNKIVFDIAYFFSVYFLFLTSVIISDILFVLSISK
                     LVEISIPINFFLIWILSYLLFIIEVSISLTIEKGEATIENIFIVAIMYFTYSQLWLFV
                     AIKGMIEYLKDIIFKREVKWYKTERF"
     gene            1298..3379
                     /locus_tag="KR257_003598"
     CDS             1298..3379
                     /locus_tag="KR257_003598"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728691.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cellulose biosynthesis cyclic di-GMP-binding
                     regulatory protein BcsB"
                     /protein_id="HBH0032254.1"
                     /translation="MKKFIISIISLVLFFSNISLIYKVNADETKVKNYKFERDITIDG
                     VIGSNSTFFEVNKNWDIEEVLLHLNFSKSQILNGDVSSLTVLINNVPIKSIKLNAKTN
                     YKNTLEVLVPKDYIIQGYNEIKIKTYKTISDKICQDDSNTGNWMVIHKESYISIRYKQ
                     KKVENSINEYPYPYAEIENNHKLDTTIVVPDNMTRGETTAVFNLASAFGKITKNDDLK
                     LDVKLYSEMKNWSDDNIIYIGKPENTAEEILDILSIKEQTLLSSNCIIKQVDSPYNKN
                     KKMMVVIGSNEDDLIKASNLLIENRLSNQVLSSSVLVNKETNIKINREQKLNLGHLTL
                     KDLGYSDFLLEGAFNQQALFDVKIPTGKVLDDGSKIILNLRYSDNLDFEKSLVTVSIN
                     DVIVGSKKLDRSHSNNDKLELKIPKDIDNKNYYQVKLTFNLSIKNSNCVTRESNNPWA
                     YVSNNSYLALSMKENETLSFENYPYPFVRDDEFNDLTVIMPDYSGSQAMTWMFRLGVT
                     LGANINSHNGNINVIRGKEFSDKYKDTNIVVFGVPHNNSVIKMLNNNLNIKFDKNYSN
                     FISNDKISFIDDYGKNISTIQLIKSPYNNQKNIMVISSMNEKNLYLGMDYLLNKSKVN
                     DLKGDTLIIDEYGEVEDLAYNLKSKKEVKDSSWNMSINKTTKVFLMISFITIIVVMIL
                     SMLYIKKYKRR"
     gene            3416..4501
                     /locus_tag="KR257_003599"
     CDS             3416..4501
                     /locus_tag="KR257_003599"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888788.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hydrolase"
                     /protein_id="HBH0032255.1"
                     /translation="MRKYMNKFKLKRSILISLIILIFIFIVYFVSIELKDRSLVNNQY
                     KGKIKSANLSVDYEINQVMKDIDKLGLNTVNVPIIINVESINSDIMSIDNNSKEKAIK
                     LIKKLNKKGISTILEAYPWIENGKLYETDWNPINKKRFFYTWQNAILNELIIDVANPL
                     DVNVLNIGSNFVHLEEYQQNWGEIIDFVQSKFDGFVTYRTNWWYTKKDDLSSKLFYEQ
                     KLNNNFFDKLDFISIAAYFELSNKPVNTVDELISALHSSTVNNRGQNIKQEIYNLYKA
                     HRKPIFFGELGFSNRESASSQPWNHTPSKAVNGEEQARCFEAYKKVFENEDWINGFSV
                     FCVGKIDDEKNFYPSKESIKVIKSWYE"
     gene            4555..5679
                     /gene="wecB"
                     /locus_tag="KR257_003600"
     CDS             4555..5679
                     /gene="wecB"
                     /locus_tag="KR257_003600"
                     /EC_number="5.1.3.14"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888791.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-N-acetylglucosamine 2-epimerase
                     (non-hydrolyzing)"
                     /protein_id="HBH0032256.1"
                     /translation="MNDIKVMTVFGTRPEAIKVAPLIKELEKRENIKSIVCVTAQHRE
                     MLDQVIETFNINVDYDLDIMEKGQSLNDITCKILNKLPLILNKENPNIILVHGDTTTT
                     LATSLTAFYNKTLVGHIEAGLRTYDKYSPFPEELNRQLTGIIADMHFAPTNLARKNLI
                     SEGKPNNNIFVTGNTAIDALKMTIKENYNHPIIDEIGNDRMILLTSHRRENLGKPMKN
                     IFRAIKRIVDDFEDVQIVYPIHLNPKIRTIADEIFGKFPEKIHIIEPLDVADFHNFLN
                     KSYMIMTDSGGMQEEAPSLGKPVLVLRDKTERTEGIEAKTLKLVGTNEDRIYNSVSDL
                     LINKDNYVQMSKASNPYGDGNASKYIVDIIIKKFNCKYLN"
     gene            5757..6731
                     /locus_tag="KR257_003601"
     CDS             5757..6731
                     /locus_tag="KR257_003601"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861074.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glucosaminidase domain-containing protein"
                     /protein_id="HBH0032257.1"
                     /translation="MARKLIKNLGKSKSVKRVKLLFKKIFITVFIVASIVAIFNITKY
                     FEELYKVRDLKSTKIEYYMDVADEAGDGKVQLSWKALLAIDMVIHDEDLSNIKKKDTL
                     DIGEKFIVEDKNDKGEKVYKVKKFNKVLSELKFDSSQKSRARKYMKDLEYTYLGNKQL
                     DSSDEKIKFIKKLEDSAIREYIDYGILPSITIGQAILESGWGNSKLTKQSNNLFGIKA
                     DKAWKGKSVEISTSEHYNEKIVASFRSYNSLQDSVKDHSLFLINNKRYRKHGLFEAKD
                     YISQAQSLENAGYSTAEDKKGNRIYAELLIDVIRSYNLQLIDNKVETK"
BASE COUNT         2865 a          646 c         1143 g         2220 t
ORIGIN      
        1 atattttagg agaaatttat gagagattta aatgtatcag agtatttgtt cgtatttagt
       61 ctgtttagta tatggtcttt attgcttata aatattattt tagctatggg tggatatata
      121 ttttatttta aaaactttga taaagaaata aaagaaattg atgaatatcc tatgatatca
      181 atacttgttc ctgctcataa tgaagctaaa gtgataggta gaactgtgga gtctttgcta
      241 ttactcaatt atcctaagag taagatggaa cttattgtta taaatgacaa ttcttctgat
      301 aatagtaaag aaattttaga aaatataaag gataggtaca acaattataa tttcactata
      361 ataaatacag atagtttaac aggtggaaaa ggaaagtcta atgcattaaa tattggatat
      421 acgatttcaa aaggagattt tatagctgtt tatgatgcag ataacacacc agataaaaat
      481 gcacttagat atctagtaca aactatagta atgaatgatg aattaggtgc tgttattggg
      541 aaatttagga ctcgaaataa aaataaaaac ctattaacca aatttataaa catagaaaca
      601 ttaagctttc aatggatgtc acaagctggt agatggcaac tttttaatct atgtacaata
      661 ccaggaacta actttatatt gaggagaagt atcatagaag aaattggagg atgggatagt
      721 aaagcaattg cagaagatac agaaataagt tttaggatat ataaattggg atacaagata
      781 aagcttgtac cacaatctat aacatgggaa caagagccag aaactgttaa ggtgtggata
      841 aagcaacgta ctagatgggc aaaagggaat atatatgtat taatgaaata tataaaaaat
      901 atatttaaac agggaagaaa taagattgtg tttgatatag cttacttttt ttctgtatat
      961 tttctatttt taacatctgt aattatatcc gatattttat ttgttttaag tatatctaaa
     1021 ctagtagaaa tttctattcc aattaacttt tttctaatat ggatactatc ttatctttta
     1081 tttattatag aagtgagtat aagccttact atagaaaaag gtgaagcaac aattgaaaat
     1141 atattcatag tggcaataat gtattttaca tactctcaac tatggctgtt tgtagctata
     1201 aaaggaatga tagagtatct aaaagatata atttttaaaa gagaggttaa atggtataaa
     1261 acagaaagat tttgattcat gtacaggagg aattaacatg aaaaaattta ttatatcaat
     1321 tatatcttta gtattgtttt tttcaaatat atcacttata tacaaagtaa atgctgatga
     1381 gactaaagtt aaaaattata agtttgaaag agatataact attgatggtg ttataggaag
     1441 taatagtact ttttttgaag taaataaaaa ttgggatatt gaagaagttt tattgcatct
     1501 taattttagt aagagccaaa tattaaatgg agatgtttca agtttaactg tattgataaa
     1561 taatgtacca ataaaatcta ttaaattaaa tgctaagaca aattataaaa atacattaga
     1621 agtattagtt ccaaaagatt atataattca aggatataat gaaataaaaa taaaaacata
     1681 caaaacaata tctgataaaa tttgccaaga tgattccaat actgggaact ggatggttat
     1741 tcacaaagaa tcatatatat caattagata taagcagaaa aaggtggaaa actcaataaa
     1801 tgaatatccg tatccatatg cagaaattga aaataatcat aaattagata caactatagt
     1861 agtaccagat aatatgacta gaggagagac tacagcagtg tttaatttgg catcagcatt
     1921 tggaaaaata acaaaaaatg atgatttaaa gttagatgtt aaattatatt cagaaatgaa
     1981 aaattggtca gatgataata ttatatatat tggtaaacct gaaaatacag cagaagaaat
     2041 tttggatatt ttaagtataa aggaacaaac cctattatct tcaaactgta taatcaagca
     2101 agtagattca ccatacaata agaataagaa gatgatggtg gtaattggta gtaatgaaga
     2161 tgatttaata aaggcatcaa atttattaat agaaaataga ctttctaacc aagttttatc
     2221 atcatcagta cttgtaaaca aagagactaa tataaaaatt aatagggaac aaaaattaaa
     2281 tttaggtcat ttaacattaa aagacttagg atattctgac tttttgttgg aaggagcatt
     2341 taatcaacaa gctttgtttg atgtcaaaat accaacgggt aaggtattag atgatggttc
     2401 aaagattatc ttaaatttaa gatattctga caatttagat tttgaaaaat ctttagttac
     2461 agtgtctata aatgatgtta ttgtgggaag taaaaaattg gataggtcac attctaataa
     2521 tgataagtta gaattaaaaa tacctaaaga tatagataat aaaaactatt atcaagttaa
     2581 attgacattt aatttgagta taaaaaattc gaattgtgtt actagagaga gtaataatcc
     2641 ttgggcatat gtatcaaata attcttattt ggcgttatct atgaaagaaa atgaaacctt
     2701 atcttttgaa aattatccgt atccatttgt tagagatgat gaatttaatg atttaactgt
     2761 gataatgcca gattattcag ggtcacaagc tatgacttgg atgtttagat taggtgttac
     2821 tttaggtgcg aatataaatt cacataatgg aaatataaat gtaattagag gaaaagaatt
     2881 tagtgacaag tataaggata ctaatattgt agtttttgga gtgccacata ataattctgt
     2941 tataaagatg ttaaataata atttaaatat aaaattcgat aaaaattact ccaattttat
     3001 atcaaatgat aagataagct ttattgatga ttatggaaaa aatatttcta ccattcaatt
     3061 aataaaatca ccatataata atcaaaaaaa tatcatggta attagttcaa tgaatgaaaa
     3121 aaacttatat ttaggaatgg attatttgtt gaataaaagt aaagttaatg atttaaaagg
     3181 agatacattg ataattgatg aatacggaga ggtagaagat ttagcttata atttaaaatc
     3241 taagaaagaa gtaaaagatt caagttggaa tatgagtata aataagacaa ctaaagtatt
     3301 tttaatgatt tcttttatta ctataattgt agtcatgata ttatcaatgc tatatataaa
     3361 aaaatataaa agaagataat atgataaatt tattatttta aaagaggtat ataatttgag
     3421 gaaatatatg aataaattta aattaaaaag aagtatttta atctcattaa taatcttaat
     3481 ttttatattt atagtttact ttgtaagtat tgagttaaaa gataggagtc tagtaaataa
     3541 tcaatataaa ggtaagatta aatcggccaa tttatctgta gattatgaaa taaatcaagt
     3601 tatgaaggat atagataaat tgggattgaa tacagtaaat gtacctataa ttataaatgt
     3661 agagtccatt aattctgata ttatgtcaat agataataat agtaaagaaa aggcaattaa
     3721 gttaataaaa aaattaaata aaaaaggtat ttcaacaata ttagaggcat atccatggat
     3781 tgaaaatgga aaattgtatg agactgactg gaaccctata aataaaaaaa gattttttta
     3841 tacttggcaa aatgccatat taaatgaact tataattgat gtagcaaatc cactggatgt
     3901 aaatgtttta aatattggtt ctaattttgt acatttggaa gaatatcaac aaaattgggg
     3961 tgaaataata gattttgtac aatccaaatt tgacggtttt gtaacgtaca gaactaattg
     4021 gtggtataca aaaaaagatg atttaagtag taagttgttt tatgaacaaa agctgaacaa
     4081 taattttttt gataagttag attttatatc tatagcagca tattttgagt taagtaataa
     4141 acctgttaat acagtggatg aattaatttc tgccttacac tcatctactg taaacaatag
     4201 aggacaaaat ataaaacaag aaatatataa cctttataaa gctcatagaa aacctatatt
     4261 ttttggagaa ttaggttttt caaatagaga aagtgcaagt tctcagccgt ggaatcatac
     4321 tccttcaaaa gctgtaaatg gcgaagaaca agcaaggtgt tttgaggcat ataagaaagt
     4381 ttttgaaaat gaagactgga taaatggttt ttctgtgttt tgtgtaggta aaatagatga
     4441 cgaaaaaaat ttttacccat caaaagagag tataaaagtt attaagtctt ggtatgaata
     4501 attttgaaag tgtagaattt atatagatta aatagatgat taggagagac ataaatgaat
     4561 gacatcaagg ttatgactgt atttggaact agacctgaag ctatcaaagt agcaccttta
     4621 ataaaggaac ttgaaaaaag agagaatata aaaagtattg tttgcgttac agctcaacat
     4681 agagaaatgc ttgaccaagt tatagaaacc tttaatataa atgtagacta tgatttggat
     4741 ataatggaaa aaggacaaag cctgaatgat ataacatgta agattttaaa taaacttccc
     4801 ttgattttaa acaaggaaaa tccaaatata atattggtac atggagatac aaccacaact
     4861 ctagctacaa gtttgactgc attttataat aaaactcttg ttggtcatat agaagctggg
     4921 cttagaacct atgataaata ttctcctttt ccagaggagt taaatagaca acttacaggt
     4981 attattgctg atatgcactt tgctcctact aatttggcta gaaaaaactt gatttctgaa
     5041 ggaaaaccta ataataatat atttgtaact ggtaatactg ctattgatgc tttaaagatg
     5101 acaataaaag aaaactataa tcatcctata attgatgaga ttggtaacga taggatgatt
     5161 ttactaacct ctcacagaag agaaaatttg ggtaaaccta tgaaaaatat atttagagct
     5221 ataaagcgaa tagtagatga ctttgaagat gtacagatag tatatcccat acatttaaat
     5281 cctaaaatac gaactatagc tgatgagata tttggaaaat ttcctgaaaa aattcatatt
     5341 atagagcctt tagatgtagc tgattttcat aactttttaa ataaatctta tatgataatg
     5401 actgatagtg gaggaatgca ggaagaagct ccatcattag gtaagccagt ccttgtgttg
     5461 cgtgataaaa cagaaagaac agaaggaatt gaagcaaaga cacttaaatt agtaggtact
     5521 aatgaagata gaatatataa ttcagtgagc gatttattaa taaataaaga taactatgtt
     5581 cagatgagta aagcatctaa tccatatgga gatggaaatg caagcaaata tatagtggat
     5641 ataataatta aaaaatttaa ttgcaaatat ttaaattaga taagacctaa aacattaact
     5701 aattgatata agatttatga taatattaag gaatacaatt tttaaggggg agtaatatgg
     5761 ctagaaaatt aataaaaaat ttgggtaaaa gtaaaagtgt aaagagagtg aaacttttat
     5821 ttaagaagat ttttattact gtattcatag tagcaagtat agttgctatt tttaatataa
     5881 cgaaatattt tgaggaatta tacaaagtaa gggatttaaa aagtactaaa attgaatact
     5941 atatggatgt ggctgatgaa gcaggagatg gaaaggtcca attaagttgg aaggccttac
     6001 ttgctataga catggtaata catgatgaag atttaagtaa tataaaaaag aaagacacat
     6061 tggatatagg ggaaaagttt atagtagaag ataaaaatga taaaggcgaa aaggtgtata
     6121 aggtaaaaaa gtttaataag gtattaagcg aattgaaatt tgactcttct caaaaaagta
     6181 gagcaagaaa atacatgaaa gatttagaat acacatacct tggaaataaa caattagata
     6241 gtagtgatga aaaaattaaa tttataaaga agttagaaga ctcagctata agagaatata
     6301 ttgattatgg aatattgccc tctataacaa ttggacaagc tatattagaa tctggttggg
     6361 gaaattctaa acttacaaaa cagagtaata atttatttgg tataaaagca gataaagcat
     6421 ggaaaggaaa aagtgtagaa atttcaactt cagagcatta taatgaaaaa attgtagcta
     6481 gttttaggtc gtataattca ttacaagatt ctgtcaaaga ccacagttta tttttaatta
     6541 ataataaaag atatagaaaa catggattgt ttgaggcaaa agattatatt agtcaagctc
     6601 aatcattaga aaatgcagga tatagtacag cagaagataa aaaaggaaat cgtatatatg
     6661 cagagctatt aatagatgtt attaggagtt ataatttgca attgatagat aataaagttg
     6721 agacaaaata attgttaact ttatatgagg agataacaag ataagattct tttctacaaa
     6781 aagaatagaa aaattgtaaa aaaaactaaa aaaatgtatt gacttgttat ttaaaaggtg
     6841 atattattat tactgtactc gaaagagaac aaaa
//
LOCUS       DAEPID010000132         6584 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.133, whole genome shotgun sequence.
ACCESSION   DAEPID010000132 DAEPID010000000
VERSION     DAEPID010000132.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 6584)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6584)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..6584
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.133"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            complement(619..1179)
                     /locus_tag="KR257_003602"
     CDS             complement(619..1179)
                     /locus_tag="KR257_003602"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430816.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptidoglycan-binding protein"
                     /protein_id="HBH0032258.1"
                     /translation="MLKKLKKMLLITCCLFMMSSTAFAETQNSEGKSFTISGYTFMYE
                     NAPQEIKDKYKENCLDIGVEPQPNDEIFITPSELKTYSNIDMYSARSSSFTVTYHYSY
                     YKVTGDKNYTVNTSTIVKYGNSGNPVHLVQLLLKKVGYALEVDSQFGNTTLSKVKSFQ
                     GSYGLTVDGIVGSATWKKFASATNLD"
     gene            complement(1225..2208)
                     /locus_tag="KR257_003603"
     CDS             complement(1225..2208)
                     /locus_tag="KR257_003603"
                     /inference="COORDINATES: protein motif:HMM:NF017390.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptidase M56"
                     /protein_id="HBH0032259.1"
                     /translation="MSNLILTDILRTSITSSLVICFLLLLRTTIFRIFNKGFNYYIWL
                     IVIVRLLFPFSYFTYTISDSKFQYKPILNEVDYSNTVLIIYLTIVILLAIYRFIKYLK
                     FKSLVIDLSYDIENLEINNLYNNLLKELNIEKHIKLKYTYEINTPSFFGLFDNYILLP
                     PHNYNLNELHWILKHELIHYKSKDLYIRYLVLFLKCVYFFNPFIYLLDRIIYHSCELH
                     CDEVVLKGCSLENIKSYANTILDSIERSSRDSNNYTTGLHRKSNFEKRVYDMFKNKGK
                     SGILIALILCLLSSFTYFKFDSIISKPINHSLDAPLPVNTGKEKSFTITID"
     gene            complement(2221..2583)
                     /locus_tag="KR257_003604"
     CDS             complement(2221..2583)
                     /locus_tag="KR257_003604"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903180.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="BlaI/MecI/CopY family transcriptional regulator"
                     /protein_id="HBH0032260.1"
                     /translation="MIEKIPRAELKVMMLFWDTDKVLTSRDIVNIMSEEWKQTTTLTL
                     LSRLSKRGFLEPTKKPTHTTYKILIDKKSYLEFATSDFVKNVHNDSIVSLVDSVNKEK
                     IGKDELASLRAFIKKLKK"
     gene            3826..4473
                     /locus_tag="KR257_003605"
     CDS             3826..4473
                     /locus_tag="KR257_003605"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0032261.1"
                     /translation="MNKKLEKPFVYKREYDLTGYDVEILQKYELEQAIYVYVGSSCAY
                     NMRARSSKWRYHIRTNNKSICCNIKNFIHNLELFYKMELKLSDNIINDKLYYSNIAEF
                     EEFETLEKAREVESTIISQYQFLDSINHMLKQKIILLSNKDSVLNITKNGNTNYLKVK
                     NKYIEKHKNKPIMRYHINCQFNTDGSVKSITQEFEPILELNKKNTLSRPSRVFLK"
     gene            4748..6385
                     /locus_tag="KR257_003606"
     CDS             4748..6385
                     /locus_tag="KR257_003606"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0032262.1"
                     /translation="MEQLDSKYKLKKFLMAVFRDGIGQGNNLIDNEYVRVFQNNKSNS
                     KQLELGEEFKEYSKTTFFKNIDDIVEFTFAKNIYYENTFFNLCTTDGKAGTNENLINR
                     YALGFDFDKKELGQGFNYKDIINLFTKIGLHYHILVDSGNGFHVYVLINKTNNIKLVS
                     EVTNTLINKLGADKQANLSTQVLRVPYTYNIKNTTKQVKIIHQDKNIYRYDIEKLAKK
                     YCKDVKTVGNTNTKYILDSKLPNCIVDILKNGSKDGHKNLDLQKIVVTLRLRNKSLSQ
                     VISVAREWNYISQNSLSNSELEYQVKYMYEKLKTVNFGCTGCEFNSDCWNKIESDFIY
                     SDEDTLFNMPHKHSKDLKYKNRKGVKIMTGNQLFIYNVLLNNKDRELNIDDIMELITY
                     KRKKKVKNIVMSEKTLRETLKELQHNDYITKTKGVTKLGIKDTYNVKEVRCNIDKQYT
                     ISYFVTMAVIWGIISTEELRLYTHMRYKQDLLVKDDKIKGNILRINQEELAKDLGVTQ
                     QRISNMIESLLDTKILDVWETKINDRGFMYYTYRLNK"
BASE COUNT         2683 a          692 c          917 g         2292 t
ORIGIN      
        1 ctaattagta ggtgcttttt taaaacaagt taaaaatcaa aaatagtatt agtaagcatt
       61 ggaaatgcta gattctaaaa tagaaaagta aaaaattggt gcactatcta aacttatcta
      121 tatcgctttt tccgtcgttt ggttctctag ttacgataca ggggatatgc ttatattgag
      181 ttatagtact aatcagtgct taatatagtt aataaaatta tagttaccat agtttagtaa
      241 ctatgatgta tgttagttag aaacttgcat ttcatgagtt gtaatatctt aaagtcagta
      301 gttttgattt taaaatatta attgcactgt tacaaatgac tttattaata aaaaattagg
      361 cagcttaaaa aaagtttaga ataaatttgc taggctttgc taagctattc ttttaaaaat
      421 aactttacaa aacaaacaaa taaggactta taaatataga taaaaaaaga aaattgaaaa
      481 ggattataga gacttacaag gctttaaata tatattctta attgtaaaat tatgtaatta
      541 aaatatttac tttattataa aaagacatga taaacttatt atcatgtctt ttgttaaact
      601 tatttatatg taaaaattct aatcaaggtt tgtagcagat gcaaattttt tccatgttgc
      661 actaccaaca attccatcta ccgttaagcc ataactgcct tgaaaacttt taactttgct
      721 aagtgtagtg ttcccaaatt gactgtctac ttctaaagca tatccaactt tttttaatag
      781 caattgtact aaatgaacag gatttcctga atttccgtat tttacaatcg tagaagtgtt
      841 gacagtatag tttttatctc cagtaacttt gtagtatgaa taatgataag ttactgtaaa
      901 tgaacttgac ctagctgaat acatgtctat gttgctataa gtttttaatt cactaggggt
      961 aataaaaatt tcatcattag gttgtggctc tacacctata tccaaacaat tttccttata
     1021 tttatctttt atttcttgtg gtgcattttc atacataaat gtgtaacccg aaatagtaaa
     1081 gctttttcct tcactatttt gtgtttctgc aaaagctgtg ctactcatca taaataaaca
     1141 acaagtaatt agcaacattt tttttaattt ttttaacata attcctccct ataattttga
     1201 atatatttga ataccagcaa atatttaatc tattgttata gtaaaagatt tttctttgcc
     1261 tgtattaact ggcaatggtg catctaagga gtgattaatt ggctttgata taattgaatc
     1321 aaatttaaaa tatgtaaatg atgacaataa gcataaaatc aatgctatta aaataccact
     1381 cttaccctta tttttaaaca tgtcataaac tcttttttca aaatttgatt ttctgtgtaa
     1441 tccagtagtg tagttatttg aatctcttga acttctttca attgaatcta aaattgtgtt
     1501 agcataactt tttatatttt caagggaaca accttttaat acaacttcat cacaatgtaa
     1561 ttcacagcta tgatatataa ttctatcaag tagataaata aaagggttaa agaaataaac
     1621 acactttaaa aataaaacca aatatctaat gtataaatct ttacttttgt aatgaattaa
     1681 ttcatgtttt agaatccaat gcagttcatt taaattataa ttgtgtggtg gcaaaagtat
     1741 ataattatca aataatccaa aaaatgaggg cgtattgatt tcataagtat attttagttt
     1801 aatgtgcttt tctatattta gttcttttaa taaattatta taaagattgt ttatttcaag
     1861 attttcaatg tcatatgata agtcaataac caaactctta aactttaaat attttataaa
     1921 cctataaatt gcaagtaaaa taacaattgt tagatatatt attaatactg tatttgaata
     1981 atcaacttca ttcaaaatag gtttgtattg aaatttagaa tcagaaatag tataagtaaa
     2041 ataagagaat ggaaaaagta atctaactat tacaattagc caaatataat aattaaaacc
     2101 cttattgaaa attctgaata tagttgtcct taaaagtagc agaaaacaaa taactagact
     2161 acttgtgata ctggttctta aaatatctgt tagaattaaa ttagacatat atagtaccta
     2221 ttatttctta agttttttta taaaagctct caaagatgcc aattcatctt ttcctatctt
     2281 ttctttatta actgaatcaa ctaaacttac aatagaatca ttatgtacat tctttacaaa
     2341 atcagatgtt gcaaattcta agtagctctt tttatcaatc aaaattttat aagtagtgtg
     2401 tgtaggtttt tttgtaggct ctaaaaaccc tcttttagaa agcctagata atagtgtaag
     2461 tgttgtcgtt tgtttccatt cttcactcat tatatttaca atatctcttg atgtcaatac
     2521 cttgtcagta tcccaaaata gcatcattac tttaagttca gcacgtggta ttttttctat
     2581 cataatatgt tcctccatcc taatgttaaa aaaattaata aatgtaattt tattctattg
     2641 aaatagagta ggacagtcaa ttgttttttg attaatgatt tacatatgta gagtaaatta
     2701 aaagaagtat atcacttgaa aagttttaca tacgtagagc atttttatca aatctcttaa
     2761 tttttttaat tgaattatat atgtgaatat aagagtaaat caacttaaaa catgcaaaaa
     2821 attaatattt actgacatgc aactgacaaa tcaacaaaaa taggaattga taaaataagt
     2881 gtatatattg aaattgctat aatacataca aaaatggcat aaaatactaa tttttatgtc
     2941 cttttctact gacatgtaaa aaagtcttgt aagtattgga attactagat tacataggtt
     3001 ttagatgcaa aattgtcgtt ttgtaaaaaa ggctactaaa atttataaaa acaattatta
     3061 attgatataa attatcacaa aaaaagacat ctatttctat gaaaaaaaaa ttttcgtctg
     3121 catgtaaaaa tagctatagt aatgcgtacg aatgttctat tattacagaa ttatttgtat
     3181 gtaaattata ttgaaaatat ctatcagaat tagaatttta tatggataaa acagaactat
     3241 caaataggag tatatagtaa agatttatat aatatgatga cctcgtacaa gcctgtaaga
     3301 gccgtttaaa agttgcttta gtattaatta tctttgaaaa tttaaaatag gtttaaatgg
     3361 cttgttaaat atgatgtatt actattatgt ataggggggt agttatgtag ttacatgttg
     3421 ttttaaaaaa taaatttaac tatagttctt tcacttccac attacaaaaa ataaattgag
     3481 tgtgtatgtt tttaagtaaa aatgatgttt aaatattgaa aaatagagat atagtgtatg
     3541 taaaatttag aatagtgtat gtaattttag gcataaaaat atgtgattaa accttaaaaa
     3601 ccaggaatat agtgtatgca tttttaaaaa taaaaattgt aacctttttg taatctttta
     3661 ttaaaatact tactttaagt ctaaaaatta ggggagatgt aaggatttgg gaaaaataga
     3721 agatgttata atcataaata tggtattcgt aggcttaaag tcaaaaagga ggtgaaatat
     3781 aaatagattt ttagctaaat taagtaagaa ataggaggag atttattgaa caaaaaatta
     3841 gaaaaaccat ttgtatataa gagagagtac gatttgactg gatatgatgt tgaaatttta
     3901 caaaaatatg agttagaaca agcaatatat gtttatgttg ggagtagttg tgcatataac
     3961 atgagagcta gaagtagtaa atggagatac catataagaa caaataataa gtctatatgt
     4021 tgtaacatta aaaattttat acataacttg gaattgtttt ataaaatgga attaaagttg
     4081 tcagataata ttattaatga taagctatac tatagcaata tagcagagtt tgaagaattt
     4141 gaaacactag aaaaagctag agaggtagaa agtactatta taagtcaata tcaattttta
     4201 gattctataa atcatatgtt aaaacaaaaa ataattttat tgagtaataa ggatagtgtg
     4261 ttaaacataa ctaaaaatgg aaatacaaat tatttgaaag taaaaaataa atacatagaa
     4321 aaacataaga acaagccaat aatgagatac catatcaact gtcaattcaa tacagatgga
     4381 agtgtcaaaa gtattacaca ggagtttgaa ccaatattgg aattaaacaa aaaaaatacc
     4441 ctaagccgac caagcagagt atttttaaaa taatatttta agataacaac aaaatgagat
     4501 aatactacta gacaatgaca actcaactac caattgagtt tatggagcta ccaactccaa
     4561 tatcggtcta actgattaag tatctgtagt tatataataa tattgctatc aattttagca
     4621 tcttaacaat attattatac atactaagct aaaattattc aatagttgta aaagttgatt
     4681 agtcaataag tatatattta atgtagtgtt atctcttaaa aaaactagat aaggagataa
     4741 taaatatatg gaacaattag attcaaaata taagttgaaa aaatttctaa tggcagtatt
     4801 tagagatggt ataggacaag gaaataatct tattgataat gaatatgtta gagtatttca
     4861 aaataataaa agtaatagta aacaattaga actcggagaa gaatttaaag aatatagtaa
     4921 aacaactttt tttaaaaata tagatgatat agtagaattt accttcgcaa aaaatattta
     4981 ttatgaaaat acatttttta acctatgtac aactgatgga aaagcaggaa ccaatgaaaa
     5041 cttaataaat agatatgcat taggatttga ttttgacaaa aaagaattag gacaaggttt
     5101 taattataaa gatataatta atttatttac taagatagga ttacattatc atatcctagt
     5161 tgatagtgga aatggattcc atgtttatgt gctaattaat aaaactaata acattaagtt
     5221 agtatcagaa gttacaaata cattaataaa taaattgggt gcagataaac aagcaaattt
     5281 atctactcaa gtattaagag taccttatac atataatatt aaaaatacta ctaaacaagt
     5341 aaaaataata caccaagaca aaaatatata tagatatgac atagaaaagt tagctaaaaa
     5401 atattgcaaa gatgtaaaaa cagtaggtaa tactaataca aaatatatat tagatagtaa
     5461 gctaccaaat tgtatagtag atattttaaa aaatggtagt aaagatggac ataaaaacct
     5521 agatttgcaa aaaatagttg tgactttaag attgaggaat aaaagtttaa gtcaagtaat
     5581 atccgttgct agagaatgga actatatatc acaaaatagt ctttcaaata gtgagctaga
     5641 atatcaagtc aagtatatgt atgagaagct taaaacggtt aattttggtt gtacaggttg
     5701 tgagtttaat agtgattgtt ggaataaaat agaatcagat tttatatata gtgatgaaga
     5761 tactttgttc aatatgccac ataagcactc aaaggatttg aaatataaga ataggaaagg
     5821 ggttaaaata atgactggta atcaattgtt tatctataat gtgttactta acaataaaga
     5881 tagagaatta aacatagacg atataatgga gctgataacc tataaacgta agaagaaagt
     5941 taaaaacatt gttatgagtg aaaagacatt aagagaaaca ttaaaagaac ttcaacataa
     6001 tgattatatt acaaaaacaa aaggtgttac aaagctagga ataaaagata catacaatgt
     6061 aaaagaagtt agatgtaata tagataaaca atatactatt agttactttg ttaccatggc
     6121 agtaatttgg ggaataattt caactgaaga attaagatta tatactcata tgagatataa
     6181 gcaagattta ttggtcaaag atgataaaat aaaaggaaat atattaagaa ttaatcaaga
     6241 ggaattagca aaagatttag gagtaacaca gcaaagaatt tcaaatatga tagaatcttt
     6301 attagatact aaaattttag atgtatggga aactaaaata aatgatagag gatttatgta
     6361 ctatacatat agattaaaca agtagatttt tgataggatt agaattgatt ttctagtcct
     6421 atttttatgc aaaaaaacta attaataaaa atttcttttg gtaaaataat tgtacgagaa
     6481 ttgcaaaaaa aaaatggcat caaagtattg aaattaagcc gttttaaaaa tttcttttgg
     6541 taaaataatt gtacatatat atgtagtata tatatatatg tttt
//
LOCUS       DAEPID010000133         6509 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.134, whole genome shotgun sequence.
ACCESSION   DAEPID010000133 DAEPID010000000
VERSION     DAEPID010000133.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 6509)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6509)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..6509
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.134"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            390..1334
                     /locus_tag="KR257_003607"
     CDS             390..1334
                     /locus_tag="KR257_003607"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902566.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP phosphoribosyltransferase regulatory
                     subunit"
                     /protein_id="HBH0032263.1"
                     /translation="MKFLRIEDEVIYSKKRYKLKREIDKLFLDEEYFQIEPQLFEEYD
                     EFTTINNKIPEESMVKVVNGKVMVLRADITTSIIKSLVPRWEDGLKLKLFYNSSIYKN
                     KNTVGIKEIRQIGCEYLGEASVEADREVVKLALKILEKYNNNFILEVGSSKYIHGLLE
                     ELNLNKNCENQIKNLLYTKNTHELKVYIEELKIKREVKELLSNILSLQGNLYNVIEKS
                     NKFYCNNKMKQALEELKQVNNLIEECNFLDKARFDLSMITMLDYYEGIMFRGYYPNSY
                     KEILSGGRYDSLTKEYGKEIPAIGFTLSVDELMKYVYK"
     gene            1356..1982
                     /locus_tag="KR257_003608"
     CDS             1356..1982
                     /locus_tag="KR257_003608"
                     /EC_number="2.4.2.17"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902568.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP phosphoribosyltransferase"
                     /protein_id="HBH0032264.1"
                     /translation="MDYLTIALAKGRIEGESFKKFKKMGLGDSIDTDTRKLIFKDEEN
                     KIIYIHVKPSDVVTYVEKGVADLGIAGKDTILENETDVYEIYDLGFGKCKFAVAGLKG
                     DSIYREDEYLKVATKYPNIAKKYFKEKGQKIEIIKLNGSVELAPIVGLSDVIVDIVET
                     GNTLKANGLEILEDICNISARIISNRASYRFKYEQIQNIIRLFEELDN"
     gene            2016..3065
                     /gene="hisC"
                     /locus_tag="KR257_003609"
     CDS             2016..3065
                     /gene="hisC"
                     /locus_tag="KR257_003609"
                     /EC_number="2.6.1.9"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429779.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="histidinol-phosphate transaminase"
                     /protein_id="HBH0032265.1"
                     /translation="MREKESIRELKGYEPNHVNCKVKLDANEGSKRLFKYLIKEISDS
                     DIDLNLYPEDSYSDLKESIIDYINISGVNKKNLLVGNGSSEIIDLIIHTFVDKDEVIL
                     SFSPSFSMYSIYSQINGSKFIGVESDENLVINIDNVIEKVKENNPKIVIVCNPNNPTG
                     TILKREEIIKLLDSTNSLVVLDEAYMDFGEESMLSDVFKYDNLIVLRTLSKAFGLAGI
                     RTGYMLSNSSLINSVEKVRPPYNLNSLSDFIATRALRNKDVVKAYIKEVKEEREVLYK
                     EMIGMGIKAYKSQANFILFYSEIENLSQKLIDRGVLIRKFGGKLENYYRVTIGDKEEN
                     SMFVGAIRDILKKEK"
     gene            3068..3646
                     /gene="hisB"
                     /locus_tag="KR257_003610"
     CDS             3068..3646
                     /gene="hisB"
                     /locus_tag="KR257_003610"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902569.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="imidazoleglycerol-phosphate dehydratase HisB"
                     /protein_id="HBH0032266.1"
                     /translation="MRIWKVERNTLETQILVELNIDGSGKAEIDTGIGFLDHMLTLMS
                     FHGKFDLKVICKGDTYVDDHHSVEDIGIAIGEAFKNALGDKKGIRRYSNIYIPMDESL
                     SMVAIDISNRPYLVFNAKFDTQMIGSMSTQCFKEFFRAFVNESRVTLHINLLYGENDH
                     HKIESIFKAFARALKEGSEIVSNEIASSKGVL"
     gene            3648..4253
                     /gene="hisH"
                     /locus_tag="KR257_003611"
     CDS             3648..4253
                     /gene="hisH"
                     /locus_tag="KR257_003611"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436678.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="imidazole glycerol phosphate synthase subunit
                     HisH"
                     /protein_id="HBH0032267.1"
                     /translation="MNIIVDYGLGNIDSVSRGFRKAGIETKISSDIDEIKQADSLILP
                     GVGAFRDSISALDKLGLIPIIKEHVSKGKFMIGICLGMQLLYEKSYEYGEYEGLGLIK
                     GSIDKLDISLKVPHMGWNNLKFNKANDDILKYINEDDYVYFVHSYYANSSNEELIAFS
                     EYEKKIPAIVRKGNVYGIQFHPEKSGEVGLNILRAYGEMIK"
     gene            4250..4972
                     /gene="hisA"
                     /locus_tag="KR257_003612"
     CDS             4250..4972
                     /gene="hisA"
                     /locus_tag="KR257_003612"
                     /EC_number="5.3.1.16"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896508.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="1-(5-phosphoribosyl)-5-[(5-
                     phosphoribosylamino)methylideneamino]imidazole-4-
                     carboxamide isomerase"
                     /protein_id="HBH0032268.1"
                     /translation="MIIFPAIDIKDNKCVRLTQGEFDKVNVYYDNPLEVAYKWKNEGA
                     EYIHIVDLNGARSEFGVNTKIIEDIANNIDIPIQVGGGVRDKEKVKSLINAGVTRVIL
                     GSIAIENLNLVEELVNEYKEKIVVSIDAKDGKVAVRGWEVVSNVDSLTLCKQLEKIGV
                     QTIVYTDISKDGMLQGPNFDIYERIAKETSLNVIASGGVTSIEDVKRLKAMNLYGAII
                     GKALYDKKIDFKEAQQLCLLGE"
     gene            4954..5712
                     /gene="hisF"
                     /locus_tag="KR257_003613"
     CDS             4954..5712
                     /gene="hisF"
                     /locus_tag="KR257_003613"
                     /EC_number="4.1.3.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000880088.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="imidazole glycerol phosphate synthase subunit
                     HisF"
                     /protein_id="HBH0032269.1"
                     /translation="MLTRRIIPCLDVRNGRVVKGKKFKDIVDVDSPEVLGKFYSDCGA
                     DELVFYDITASNEERKTSLEFVTKVAENINIPFCVGGGVNKLEDFTDILRKGADKVSI
                     NSSAVKNPELIREASLKFGAQCVVLSIDAKKNEEGSWSVYVKGGREKTNLDAIEWAVK
                     GVELGAGEIVVNSMDEDGMKNGYDIELLSKITSLVNVPVIASGGAGKKEDFYEAVNKS
                     NVDGILAASVFHFGEIKINDLKKYLKDMGVEVRL"
     gene            5740..6408
                     /locus_tag="KR257_003614"
     CDS             5740..6408
                     /locus_tag="KR257_003614"
                     /EC_number="3.5.4.19"
                     /EC_number="3.6.1.31"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436669.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional phosphoribosyl-AMP
                     cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE"
                     /protein_id="HBH0032270.1"
                     /translation="MDNKCNNVYSDEVEKFIRSIKFDDKGLVPVVVQEVVSKDVLMLA
                     YMNKDAIKKTLKDKVACYFSRSRQELWVKGETSGNTQKVVKMSYDCDVDTILLFVEQT
                     GVACHTGNYSCFYRDLFDDSSKMELEVQTNILKELYDLINERKNNPVEGSYTNYLFEK
                     GIDKILKKVGEESSEVIIASKNTDKSELIYEISDLVYHTLVLMIEKGVEIDEIKKELL
                     KRRK"
BASE COUNT         2667 a          548 c         1264 g         2030 t
ORIGIN      
        1 ataaacaaaa gttacatata aaatatttta ttcaattttt taaataacta ttgccaattt
       61 ttgaaaaata tattattatt aatagtaaca aaaaactgta aatttagaat attaataaaa
      121 attatttggg aggaaattat catggtgaga ttaaatatag taaaattaaa tacaaaatta
      181 aatcatcacc atcatcatag attaaaggga ttgtaatatg aaattaattc atagacacaa
      241 gccctgtttt tagtgtaatt ggtcttgtat ctatgatggg aagtaatttt aagagaaaat
      301 tatagccata taggtataaa gcctatgtgg cttttttatt gttttaaatt tgcaaatata
      361 agagtaaatt taatgaagag ggtgagaatg tgaaattttt gaggattgaa gatgaggtta
      421 tttattctaa aaaaagatat aaattaaaaa gggaaataga taaacttttt ttggatgaag
      481 aatattttca aatagaacca caattatttg aagaatatga tgaatttaca actataaata
      541 ataaaattcc agaagaatct atggtaaagg ttgtaaatgg aaaagtaatg gtacttagag
      601 ctgatataac tacaagtata ataaaaagcc ttgtaccaag atgggaagat ggtttaaagc
      661 ttaagctttt ttataattca tcaatatata aaaataaaaa tacagttgga ataaaagaga
      721 taagacaaat aggttgtgag tatctaggag aagcctctgt agaagcagat agagaagtag
      781 tgaaattagc tcttaagata cttgaaaaat acaataataa ttttattcta gaggttggga
      841 gtagcaagta tattcatggt ttgttagaag aattaaattt aaataagaat tgtgaaaatc
      901 aaattaaaaa tttactatat acgaagaaca ctcatgaact aaaagtatat attgaagaat
      961 taaaaattaa gcgtgaagta aaagagttat tatcaaatat tttaagttta caagggaatt
     1021 tatataatgt tattgaaaaa tcaaacaagt tctattgtaa taataagatg aagcaagctc
     1081 ttgaagaatt aaagcaagta aataacttga ttgaggaatg taatttttta gataaggcta
     1141 gatttgattt atcaatgatt actatgcttg actattatga aggaattatg tttagaggat
     1201 actacccaaa ctcatataaa gaaattctta gtggtggaag atatgattct ttaactaaag
     1261 agtatggaaa agaaattcca gccattggat ttacactaag tgttgatgag ttaatgaagt
     1321 atgtatataa gtaaagttta gaaggaggga ttgctttgga ttatttgact atagcactag
     1381 caaaaggacg aattgaaggg gaatcattta aaaaatttaa aaaaatgggt ctaggagaca
     1441 gtatagacac agatacgaga aaactaattt ttaaagatga agaaaataaa attatatata
     1501 tacatgtaaa gccatcagat gtagttacat atgttgaaaa aggagtcgct gacctcggta
     1561 tagcaggtaa agatactatt ttagagaatg agacagatgt atatgaaata tatgatttag
     1621 gttttggaaa atgtaaattt gctgtagcag gattaaaggg agatagcata tatagagaag
     1681 atgaatattt aaaagtggca acaaagtatc ccaatatagc aaaaaagtat tttaaagaga
     1741 aaggtcaaaa aattgaaata ataaaattaa atggttctgt agaactagct ccaatagtag
     1801 ggttgtcaga tgtaattgta gatatagttg agactggcaa tacacttaaa gcaaatggtc
     1861 ttgaaatatt agaagacata tgtaatataa gtgctagaat tatatcaaat agagctagct
     1921 atagatttaa atatgaacaa attcagaata taattcgttt atttgaagaa cttgataatt
     1981 aaaatataat tgagctttat aaggagggat ttaagttgag agaaaaagaa agcataagag
     2041 agttaaaggg atatgaacca aatcacgtaa actgtaaagt aaaacttgat gcaaatgaag
     2101 gaagtaagag gttgtttaaa taccttatta aagaaatttc agatagtgat atagatttaa
     2161 atttatatcc tgaagattct tatagtgatt tgaaagaatc tataatagat tacataaata
     2221 tttctggagt aaataagaaa aatcttctag taggaaacgg ttcaagtgaa ataattgatt
     2281 taataataca tacttttgta gataaagatg aagtaatatt gagtttctct ccaagtttta
     2341 gtatgtattc tatatatagt cagataaatg ggtctaaatt tataggtgtt gaaagtgatg
     2401 aaaatttagt tataaatata gataatgtga ttgaaaaagt aaaggagaat aatcctaaaa
     2461 tagtaattgt atgtaatcct aataatccaa ctggaacaat attaaagagg gaagagataa
     2521 taaagctttt agattcaact aatagtctag tggttttaga tgaagcatat atggattttg
     2581 gagaagaaag catgttaagt gatgttttta agtatgataa tctaatagtt cttagaactt
     2641 tatcaaaggc atttggattg gctggaataa gaacaggata tatgttatct aatagtagtt
     2701 taataaattc tgttgagaaa gtaagacctc catataattt aaattcatta tcagacttta
     2761 ttgctacaag agcacttaga aataaagatg tggtaaaggc ttatataaag gaagtaaaag
     2821 aggaaagaga agttttatat aaagaaatga ttggtatggg aattaaagca tataaatcac
     2881 aagcaaattt tatattattt tattctgaaa tcgaaaattt atcacaaaaa cttattgata
     2941 gaggtgtttt aataagaaaa tttggtggaa agttagaaaa ttattacaga gttacaattg
     3001 gtgataaaga agaaaattct atgtttgttg gagctataag agatattttg aaaaaggaga
     3061 aataggtatg agaatttgga aggtagaaag aaatactctt gaaacacaga ttttagtaga
     3121 attaaatatt gatggttctg gtaaagctga aatagatact ggaataggat ttttagacca
     3181 tatgcttacc ttaatgtcat ttcatggcaa gttcgattta aaagtgattt gtaagggtga
     3241 tacatatgta gatgaccacc atagtgtaga agatataggt atagctatag gtgaagcatt
     3301 taaaaatgct ctaggtgaca aaaaaggaat acgaagatat tctaatatct atatacctat
     3361 ggatgaatct ctatcaatgg tagcaataga tataagcaat agaccttatc ttgtatttaa
     3421 tgctaaattt gatacccaaa tgattggtag tatgagtact caatgcttta aagaattttt
     3481 tagagctttt gtaaatgaat cgagagtaac attacatatc aatctcttat atggggaaaa
     3541 tgaccatcat aagatagaaa gtatttttaa agcatttgca agagctttaa aagagggtag
     3601 tgaaatagtt tctaatgaga tagcatcttc aaagggggtt ttgtagaatg aatataatag
     3661 tagactatgg tcttggaaat atagattctg tgtctagggg ttttagaaaa gctggaatag
     3721 aaactaaaat ttctagtgat atagatgaaa taaaacaggc agattcactt atacttccag
     3781 gtgttggagc ttttagagat tctataagtg ccttagataa actaggattg ataccaataa
     3841 taaaggagca tgtttctaag ggtaaattta tgataggtat atgtctagga atgcaattac
     3901 tttatgaaaa aagttatgag tatggagaat atgaaggatt aggacttata aaaggaagta
     3961 ttgataaact ggatataagt ttaaaagtgc cacatatggg atggaataat ctaaaattta
     4021 ataaggcaaa tgatgatata cttaaatata taaatgaaga tgattatgta tacttcgttc
     4081 actcatatta tgcaaattca tcaaatgaag aactaattgc attttcagaa tatgaaaaga
     4141 aaatccctgc tattgttaga aaaggcaatg tatatggtat acaatttcat cctgaaaaaa
     4201 gtggagaagt agggttaaat atattaagag catatgggga gatgataaaa tgataatatt
     4261 tccagcaata gatataaaag ataataagtg tgtaagactt acacaaggag aatttgacaa
     4321 agtaaatgta tattatgata atccattaga agtagcatat aaatggaaaa atgaaggagc
     4381 agaatatata catatagtag atttaaatgg tgctagaagt gaatttggtg taaatacaaa
     4441 aataattgag gacatagcaa acaatataga tatacctatt caagttggcg gtggagttag
     4501 ggataaggaa aaagtcaaaa gtttaataaa tgctggtgtt actagagtaa tattaggtag
     4561 tatagcgatt gaaaatttga atttagttga agaattggtc aatgaatata aagagaaaat
     4621 tgtagtttct atagatgcta aagatggaaa agtagcagtt aggggatggg aagttgtaag
     4681 caatgtagac tcattaacat tatgcaaaca acttgaaaag ataggtgtac aaactattgt
     4741 ttatacagat atatcaaaag atgggatgtt gcaaggtcca aattttgaca tatatgaaag
     4801 aatagcaaag gaaacatcac taaatgttat tgcttctgga ggcgtaactt ctatagaaga
     4861 cgtaaaaaga ctaaaagcta tgaacttata tggtgcaata ataggtaaag cgctttatga
     4921 taaaaagata gactttaagg aggcacaaca attatgctta ctaggagaat aataccttgt
     4981 ctagatgtga gaaatggaag agtcgtaaag ggaaaaaaat ttaaagatat agtagatgtt
     5041 gatagtccag aagtacttgg aaaattttat agtgattgtg gtgcagatga acttgtattc
     5101 tatgatataa ctgcatcaaa tgaagagaga aagacatctt tagaatttgt gacaaaagtt
     5161 gcagaaaata taaatatacc attttgtgtt ggtggaggag taaataaatt agaagatttc
     5221 actgatattt taagaaaagg tgctgataaa gtttctataa attcatcagc agtcaaaaat
     5281 cctgaattaa taagggaagc ttcattaaaa tttggagcac aatgtgttgt tttatcgata
     5341 gatgcaaaga aaaatgaaga gggttcatgg agcgtatacg taaaaggtgg aagagaaaaa
     5401 actaatctgg atgcaattga atgggctgtt aaaggtgtag aacttggagc aggagaaatc
     5461 gttgtaaata gtatggatga agatggaatg aaaaatggat atgatataga attattatca
     5521 aagataactt ctttagtaaa tgtacctgtc atagcatctg gaggcgctgg aaaaaaggaa
     5581 gatttttatg aggcggttaa taaatccaat gtagatggaa ttttagcagc atctgttttt
     5641 cattttggcg agataaaaat aaacgattta aagaaatatt taaaagacat gggtgtagaa
     5701 gtaagattat aagttaaata ctaaaaggag attagaaata tggataataa gtgtaacaat
     5761 gtatacagtg atgaagtaga gaaatttata agaagtataa agtttgatga taaagggtta
     5821 gtccctgttg ttgttcaaga ggtagttagc aaagatgtac tgatgttagc atatatgaat
     5881 aaagatgcta taaagaaaac cttaaaagat aaagtagctt gctattttag tagaagtaga
     5941 caagaacttt gggttaaagg tgagacatct ggtaatactc aaaaagtagt taagatgtct
     6001 tatgattgtg atgtagatac tatactactt tttgttgaac aaactggtgt agcttgtcat
     6061 acaggcaatt attcttgttt ttacagagac ttgtttgatg atagttcaaa aatggagctt
     6121 gaagtacaaa caaatatatt gaaagaatta tatgatttaa tcaatgaaag aaaaaataat
     6181 ccagttgaag gttcttatac taattatctt tttgaaaaag gaatagataa gattcttaaa
     6241 aaagtaggtg aagagagtag tgaggtaatt atagcatcaa aaaataccga taaaagtgaa
     6301 cttatttacg aaattagcga tttagtatat catacattgg ttttaatgat agaaaaaggt
     6361 gttgaaattg atgaaataaa aaaagaatta cttaaaagaa gaaaatagaa taagatagat
     6421 taatgggtaa taagaaaata taccactttt aataaaaagt ggtatatttt ttattttata
     6481 ttttgattta tagaataata tttaaatta
//
LOCUS       DAEPID010000134         6415 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.135, whole genome shotgun sequence.
ACCESSION   DAEPID010000134 DAEPID010000000
VERSION     DAEPID010000134.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 6415)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6415)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..6415
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.135"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            complement(<1..893)
                     /locus_tag="KR257_003615"
     CDS             complement(<1..893)
                     /locus_tag="KR257_003615"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729419.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AraC family transcriptional regulator"
                     /protein_id="HBH0032271.1"
                     /translation="MKDKNTYFNRKGQENFIDIFLKDDIKKGANFKRHWHEHLQIYYF
                     IDGIAYLECGLDNFKVVPGNIVIANSNELHYLESLSDNLKFYSIRIEPTFLFSNQVDL
                     LQTKYLAPLALNHIVFNNLIQNDSLILKCITTILDEYHNKEVGYELSIKANIYQLIVL
                     LLRSHIDKIYSEDEFIKRKYSLEKFECIFDLIEEKYMDKITLKELASRVNLSAHHFCR
                     TFKQITGKTTIDFINGIRLDKAIYYLKETDLNMTEIAMRCGFDSINYFSRLFKKNYNI
                     SPTKYRNEHREVSNVILKEDM"
     gene            1034..2461
                     /locus_tag="KR257_003616"
     CDS             1034..2461
                     /locus_tag="KR257_003616"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897169.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MFS transporter"
                     /protein_id="HBH0032272.1"
                     /translation="MTNSFKKDDNRKKITVLFVVIAMTFMATLDSSIINVALPVLASK
                     LNVSLASIEWVIASYSIIICSTLLFFGRLGDIIAKSRVFQVGTILFTSASLLCGLSNS
                     LTLLIVCRFIQGIGASAYMANNHGIITELFPKESRGKALGILVTAVAIGNMVGPSVGG
                     FILSIFNWNVIFFINIPIGLIVIFLNTKFLPNSKKSSENMDKTGAILQFLGTTLFFSA
                     LISAQQTGLLNPYILIALLLSIIFIILFLILEKKHPQPLLDLEIFRNFKFSLNLICAL
                     TSFICIASSSILIPFYLQSTMKLPPIQAGLFMILSPLILAIFSPIFGNISDKIKSEKI
                     ILIGLLVMSFGFFLMSRLKESSALILFVIYISIISIGQAIFQPANNALIMSSCSRSKL
                     GVVGSINSLVRNLGQVIGITISTTLLYNFMSIKAGYRVNDYVINNDKIFVFGMRNVYI
                     IVTLVCLIGAILIGFYLFKYNKNEQ"
     gene            complement(2657..5251)
                     /gene="clpB"
                     /locus_tag="KR257_003617"
     CDS             complement(2657..5251)
                     /gene="clpB"
                     /locus_tag="KR257_003617"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424228.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-dependent chaperone ClpB"
                     /protein_id="HBH0032273.1"
                     /translation="MDVEKMTLRVQKSLNEAYNEAVKNHNQQVDVIHLFSALINQEDG
                     LIPNIIEKMNISIDSLRNTVNFEIDKLPKVYGEGADSQGVSATRKINEVLIKAESISK
                     EFKDSYISVEHVMLAMMETESKSAVGKILKQYNINKNDFLNILSQVRGSQRVETQDPE
                     GTYDALARYGTNLVDLAKKNKLDPVIGRDEEIRRIIRILSRRTKNNPVLIGEPGVGKT
                     AIVEGLAERIVRGDVPEGLKDKIVFSLDMGALIAGAKYRGEFEERLKAVLKEVQSSDG
                     KIILFIDEIHTIVGAGKTEGSMDAGNLIKPMLARGELNCIGATTFDEYRKYIEKDKAL
                     ERRFQPVIAEEPTVEDTISILRGLKERFEIHHGVRIHDNAIVAAAKLSHRYIQDRFLP
                     DKAIDLIDEAGAMIRSEIDSLPTELDVVRRKLFTLETEREALLKENDDKSKSRLDDIQ
                     KEIAELKSKNDEMTAKYEKEKSQILDIKNLKAQLDEAKGKAEKYEREYDFNKAAEVKY
                     GEIPKLEEQIKQYEENMNDGSENSLLKEEVTEEEISSIVSKWTGIPVTKLVEGEREKL
                     LKLEDELHKRVIGQDEAVTAVSNAVIRARAGLKDERKPIGSFIFLGPTGVGKTELAKT
                     LARNLFDSEDNIIRIDMSEYMEKHAVSRLVGPPPGYVGYEEGGQLTEAVRRAPYSVIL
                     FDEIEKAHEDVFNMFLQILDDGRLTDNKGKTVDFKNTLIIMTSNIGSNYLLEAGGNIT
                     ETTNNLVMNEMKHRFKPEFLNRVDDIIMFKPLDQENIKKIIDIFMKDLKNRLKEKDIT
                     IEVTNSAKDVMVREGYDPVYGARPLKRYIGNTLETIIAKKLIAGDVYNGCTIVIDGKD
                     ENIEVLVK"
     gene            complement(5288..5884)
                     /locus_tag="KR257_003618"
     CDS             complement(5288..5884)
                     /locus_tag="KR257_003618"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435191.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0032274.1"
                     /translation="MSLKLDRNVLQWFDYVFENEKTSLRHYNFNCTLKEISSTSLNKV
                     AFILEKNNSKYWKLYFEIPAEVTLKLKQNIHPLFREYIYEQISLYNNNQIYNFVNSNI
                     LKVFNNIAIYQYNILENLYTIDFKKSFIDKCQYLLIGEKRLIDEDLYLIAKSKEVFDF
                     FNSDGTFNLTLSFDIQKNENLLDSLLELRKSIIINERI"
     gene            complement(5901..6305)
                     /locus_tag="KR257_003619"
     CDS             complement(5901..6305)
                     /locus_tag="KR257_003619"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861430.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="replication/maintenance protein RepL"
                     /protein_id="HBH0032275.1"
                     /translation="MDKTLKKDLNQEYTESKSLVMNKSKYMNVCFKNYIKVVEGMYTK
                     RDLIPLKLINSMDKNNKIRKTLYELSCEFEYPKTSLSSLFTELKKMDFLQRVKNGEYM
                     INPHIAYKGSRADKESLLAEYNQIKRPNKVSK"
BASE COUNT         2048 a         1049 c          684 g         2634 t
ORIGIN      
        1 ttcatatctt cttttaaaat aacattacta acttctctat gttcatttct atacttagtt
       61 ggagatatat tataattctt tttaaataag cgactaaaat aatttatgct atcaaagcca
      121 catctcatag caatttctgt catatttaaa tctgtttcct ttaaataata tatagcttta
      181 tcaagcctga ttccatttat aaaatcgatt gtagtcttac ctgttatttg cttaaatgtt
      241 ctacaaaagt gatgtgcact caagttcaca cgactagcaa gttcttttaa tgtaatttta
      301 tccatatatt tttcttctat caaatcaaag atacattcaa atttttctaa agaatacttt
      361 ctttttataa attcatcttc agaatatatt ttatcaatat gacttcttaa taagagtact
      421 attaattgat agatattagc ttttatagat aactcatatc caacttcttt attgtgatat
      481 tcatcaagta tagttgtaat acattttaaa atcagagaat cattttgaat taaattatta
      541 aatacaatat gatttaaagc caatggtgct aagtacttgg tttgtaacaa atcaacttga
      601 ttactaaaaa ggaatgtggg ttcaatacga atactataga attttaaatt atctgataag
      661 ctttctaaat aatgtaattc attactgttt gctattacaa tatttccagg cactacctta
      721 aaattatcca atccacattc aagatatgct ataccatcaa taaaataata tatttgtaga
      781 tgctcatgcc aatgtctttt aaagtttgct ccttttttaa tgtcatcctt taaaaaaata
      841 tctataaagt tttcttgacc tttcctgtta aaatatgtat ttttatcctt cattattccc
      901 ccctcatcaa aatagtgcta attataagca atatagttat tgtattcatt atttcatatc
      961 gctattatat aaaatgtaac tatcattgta aacattaaca taatgcagtc attataataa
     1021 ggaggtaata aaaatgacaa actcttttaa aaaagatgat aatagaaaaa aaatcacagt
     1081 tttatttgta gtcattgcca tgacttttat ggcaacatta gattctagta ttataaatgt
     1141 tgctctccca gttcttgcaa gcaaactaaa tgtatctcta gcatctattg aatgggtaat
     1201 agcaagttac tcaattatta tttgttcaac actattattt tttggaagac ttggagatat
     1261 tattgctaaa tcaagagtat ttcaagtagg tactattctc tttacatcag cttcattact
     1321 atgtggatta agtaattctt taactttact tatagtttgc cgctttattc aaggaatagg
     1381 cgcttctgcc tacatggcaa acaatcatgg aattatcaca gaactatttc caaaagaaag
     1441 cagaggaaaa gccctaggga ttttagttac tgcagttgct attggaaata tggttggacc
     1501 atctgtggga ggatttattt tgtcaatatt taattggaat gttatatttt ttataaatat
     1561 tccaatcggt cttattgtaa tctttttaaa tacaaaattt cttcctaata gtaaaaaatc
     1621 ttcagaaaat atggataaaa ctggtgctat acttcaattt ttaggaacaa cattattttt
     1681 tagtgctcta attagtgctc aacaaacagg attactaaat ccatatatat taattgcact
     1741 attattatca attattttta ttatattatt tttgatatta gaaaaaaaac atcctcaacc
     1801 gcttcttgac cttgaaattt ttagaaattt taaattttca ttgaatttaa tttgtgctct
     1861 tacatcattc atttgtattg catcatcaag tattttaatt ccattttatt tacaaagtac
     1921 tatgaaactt ccccctattc aagcaggttt atttatgata ctatcacctt tgattttagc
     1981 cattttttca cctatatttg ggaatatatc agataaaatt aagtcagaaa aaattatttt
     2041 aattggtctt ctcgttatga gttttggatt ctttctaatg tcaagattga aagaaagttc
     2101 tgcccttatt ttatttgtaa tttatatatc gataatatca ataggacaag ctatatttca
     2161 acctgctaac aatgctttga taatgtcaag ctgttctaga agtaagctag gagttgtagg
     2221 aagcataaat tcccttgtaa gaaatttagg acaagttata ggtattacta tttctacaac
     2281 acttttatat aattttatga gtattaaagc tggatatagg gtcaatgatt atgtgattaa
     2341 taatgataaa atatttgtat ttggaatgag aaatgtttat attattgtta cacttgtttg
     2401 cttaataggt gcaatattaa ttggctttta tttatttaaa tataataaaa atgaacaata
     2461 gtttttataa ttatattcaa attatgatta tattataaga aatttactaa aatacttcct
     2521 ttgagttaaa tttaatttgg acatattgac ttaaaaatgt tttattaatt tgataaaata
     2581 tttcttttcc tatagtttat aaataaaaat cagctgagca aaatatttag tatattatgc
     2641 tcaactgatt cttttattat ttaactaaaa cttcaatatt ttcatctttt ccatctataa
     2701 ctatagtaca tccattatac acatctccag caataagttt ctttgcaatt atagtttcta
     2761 atgtatttcc tatatatctc ttaagaggtc ttgctccata tacagggtca tatccttctc
     2821 tcaccataac atcttttgct gaatttgtaa cttcaatagt aatatctttt tcttttaatc
     2881 tattttttaa atctttcata aatatatcta taattttctt gatattttct tggtctaaag
     2941 gcttaaacat tataatatca tctactctgt ttaaaaactc aggtttaaat ctatgcttca
     3001 tttcattcat tactaaattg ttagtagtct ctgttatatt tcctcctgct tctaatagat
     3061 aattacttcc tatattagaa gtcattatta taagagtatt tttaaagtct actgtcttac
     3121 ctttattatc agtaagtcta ccatcatcta atatctgtaa gaacatgtta aatacatcct
     3181 catgtgcttt ttctatctca tcaaatagta ttacagaata aggagcacgt ctaactgctt
     3241 ctgtaagttg accaccctct tcatatccca cgtaccctgg aggaggtcca actagtcttg
     3301 atacagcatg tttttccatg tattcagaca tatctattct tattatatta tcttcactat
     3361 cgaataaatt tctagcaaga gtttttgcaa gttcagtttt accaacacct gtagggccta
     3421 agaaaataaa tgaaccaatt ggttttcttt catcttttaa tcctgctctt gcacgtatta
     3481 ctgcatttga aactgctgta actgcttcat cttgtccaat aactctttta tgaagttcat
     3541 cttctagttt aagtaatttt tctctttctc cttcaactag tttagttact ggtatacctg
     3601 tccactttga tacaatgcta gatatttctt cttcagtaac ttcttctttt aaaagagaat
     3661 tttcagaacc atcattcata ttttcttcgt actgctttat ttgttcttct aacttaggta
     3721 tttcaccata tttaacctct gctgctttgt tgaaatcata ttctctttca tacttttcag
     3781 ctttaccttt agcttcgtct aattgagcct ttaagttttt aatatctaat atttgactct
     3841 tttctttttc atattttgct gtcatttcat catttttaga ttttaactct gctatttctt
     3901 tttgaatatc atccaatctt gatttacttt tatcatcatt ttctttaagt aatgcttctc
     3961 tttcagtttc taatgtaaat aactttcttc taacaacatc taattctgtt ggcaatgaat
     4021 ctatttcact acgaatcata gctccagctt catcaattaa atcaattgct ttatctggta
     4081 aaaatctatc ttgtatatat ctatgagaaa gttttgctgc tgctacaata gcattatcat
     4141 gtattcttac tccatgatgt atttcaaatc tttcttttaa acctctaagt atagatattg
     4201 tatcttcaac agtaggttct tctgcaatta caggctgaaa acgtctttca agagccttat
     4261 ctttttctat atactttcta tattcatcaa aagtagttgc accaatacag ttcaattcac
     4321 ctcttgcaag cataggttta ataagattac ctgcatccat tgaaccttct gttttaccag
     4381 ctccaacaat agtatgaatc tcatctataa acagtataat ttttccatca gaactttgaa
     4441 cttcttttaa aactgccttt aatctttctt caaattcacc tctatatttt gcaccagcaa
     4501 ttaaagctcc catatcaagt gagaatacaa tcttatcttt taaaccttct gggacatctc
     4561 ctcttactat tctctctgct aacccttcta caattgcagt tttacctaca cctggctcac
     4621 caatcaatac aggattattt tttgttcttc ttgataaaat tcttataatc cttcttattt
     4681 cttcatctct cccaattaca gggtctaatt tatttttctt ggctaaatct actaagtttg
     4741 ttccatatct agcaagtgca tcatatgtgc cttctgggtc ttgtgtttct actctttgac
     4801 tacctctcac ttgtgataaa atatttaaaa agtcattctt atttatatta tattgtttta
     4861 atattttacc aacagctgat tttgattctg tttccatcat tgcaagcata acatgttcta
     4921 cacttatata tgaatcttta aattctttag aaatactctc tgcctttata agcacctcat
     4981 ttatttttct agtagctgat actccttgtg agtcagcacc ttctccatat acttttggaa
     5041 gcttatcaat ttcaaagttt acagtatttc tcaaagaatc aattgatata ttcatttttt
     5101 cgattatatt tggtatcaat ccatcctctt gattaataag tgctgagaaa agatgaatta
     5161 catctacttg ttggttatga ttttttactg cttcgttata agcctcattt aaactttttt
     5221 gaactcttaa agtcattttt tctacgtcca tataaatccc tccattttaa tattatatcc
     5281 aaataaatta aattctctca tttataatta ttgattttct aagctctaaa agactatcaa
     5341 gtaaattctc gtttttttgt atatcgaaac tcaatgttaa attaaatgtt ccatctgaat
     5401 taaaaaaatc gaatacttct tttgattttg ctattaaata caagtcttca tctataagtc
     5461 ttttttcacc tattaataaa tactgacatt tatctataaa actcttttta aaatcaatag
     5521 tgtatagatt ttctaaaata ttatattgat aaatagcaat attattaaac acttttaata
     5581 tgtttgaatt tacaaaattg taaatttgat tattgttata cagtgatatt tgttcgtata
     5641 tatattccct aaataaagga tgaatgtttt gcttaagttt taaagtaact tcagctggta
     5701 tttcaaaata aagcttccag tacttagagt tatttttttc taaaataaaa gctactttgt
     5761 tcaaactggt agaactaatc tcctttagtg tacaattaaa attatagtgt ctcaaactag
     5821 ttttttcatt ctcaaataca tagtcaaacc actgtagaac atttctatca agttttaaac
     5881 tcatataaaa accttcttcc ttatttacta accttattag gtctttttat ctgattatat
     5941 tctgctaata aactttcttt atcagctcta ctacctttat atgctatatg tggatttatc
     6001 atatactcac catttttcac tctttgtaaa aaatccattt ttttcagctc cgtaaacaat
     6061 gaagataaag aagtttttgg atattcaaat tcacaagata attcatataa tgtttttcta
     6121 atcttattat ttttatccat agagtttatt aattttaatg gaattaaatc cctcttagta
     6181 tacattcctt ctactacttt aatataattc ttaaaacaaa cattcatata cttactttta
     6241 ttcataacta aacttttgct ctctgtatat tcctgattta aatccttttt taatgtctta
     6301 tccaaattaa atatctcttc tcactctcct tatctctaat tgataatata aatatattac
     6361 aaaaaaatat gtatgtcaaa actgaaaatg caaaaagttc accttataag taaac
//
LOCUS       DAEPID010000135         6412 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.136, whole genome shotgun sequence.
ACCESSION   DAEPID010000135 DAEPID010000000
VERSION     DAEPID010000135.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 6412)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6412)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..6412
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.136"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            <1..1671
                     /locus_tag="KR257_003620"
     CDS             <1..1671
                     /locus_tag="KR257_003620"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418251.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptidase M3"
                     /protein_id="HBH0032276.1"
                     /translation="IRNYTNDTKKDSVRGTIPFEKMEYKRPNIQSICENINKCNDKLL
                     TAKTAKEQLNLFNEVDKIYQDFYSTLTIAKIRNNIDSSDEFYSKEYKYLMSKSVDVDM
                     SYKDFQDRFVTSKFSKELEKELGKDTFNYLKNIGKLNSKEVEGLLKKEQDLVVKYEDL
                     LAKSTVSIDGIEVDFEEALSRPNLSPEEYVKIYSDYLKKYNPIFGNIFLELIQTRTEI
                     ASKQGFKNYIDYAYMNLNKDYSQEEAKKFRQDVKDYIVPLYREISSKPSDSSIYIKVY
                     KNRSFRKFDKVLEDISPKLKESFDYMKKYDLYDYSSGKNKSPGGYTTYINKYKAPFLF
                     NTWDNSFLGVTSFAHEFGHFYNYYNSINLNNKMQPSIDVCEVHSTSLEILFYKYFDDF
                     FGKQSEAIKKEHLSIVLNTIIDACLYDEFQEIIYKNPYMSLNDINKLFFDLEEEYGVS
                     NNILREKNAPFWILVSHNFQVPFYYLSYGLASDVSLQIWQLSQEDYRKAVDVYMDFLN
                     QNTDAGFKDVVEKVNLQLPFQNGNLEEISSTLYDYFGIDNPLELKNAS"
     gene            complement(1835..2029)
                     /locus_tag="KR257_003621"
     CDS             complement(1835..2029)
                     /locus_tag="KR257_003621"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418249.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0032277.1"
                     /translation="MKIITIGSSLITVLLFLSTMVCGFWIKNNKVTDASSIKFHMNSA
                     IFTGIFLLISTILLIIYIKK"
     gene            complement(2026..2607)
                     /locus_tag="KR257_003622"
     CDS             complement(2026..2607)
                     /locus_tag="KR257_003622"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895741.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="HBH0032278.1"
                     /translation="MKSNDKDARERIIEVTLNLLNEVDDIEEITVRKIAERANVGVGL
                     INYHFKTKDNLLSTAIGDVMSNIIAELYDDSVYTLRPIEDLKNLLKKLCDTGLHYEKV
                     LPFVLNQCITNGDMQAELDIVPMLRKIFGNKKDEMSLRIIALQIILPIQISALSTESF
                     QLYSGINIKNKYERDKFIDILIENIIGEDVDVR"
     gene            2775..3593
                     /locus_tag="KR257_003623"
     CDS             2775..3593
                     /locus_tag="KR257_003623"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003432306.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MerR family transcriptional regulator"
                     /protein_id="HBH0032279.1"
                     /translation="MFKIGDFSKLSKISIRMLRHYDEIGLLTPSHTNKTNGYRYYSAD
                     QLSTTNRIHALKDMGFGLYSIKEILTEYNDKESLIKYLNIHHSQVKEQLEDTQKKLLK
                     IETTIKRIGGNDIMKNYDVTIKNFAPKYMMTLRRVIPTYQDEGMLWHQVFLETKDQNV
                     QIEPPKYSKAVFYDTGYKEDYVDVEVQVAVSGKYKDTEHVKFKTVPSVTAATAIVNGN
                     FNQVADACEAIGNWISDNNYDVDGPMFNIYHVSPGNDSNPDNWVTEVCFPVKKK"
     gene            4268..5089
                     /locus_tag="KR257_003624"
     CDS             4268..5089
                     /locus_tag="KR257_003624"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002572585.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="metallohydrolase"
                     /protein_id="HBH0032280.1"
                     /translation="MKLKIVGSGGMSIIPSSFCKCKICEEARQKGGRYERLGPSLYID
                     DIKMLIDTPEDIAVACNRQKISEVKHISISHHDPDHVKGIRIVEKIGCDFITGENNPI
                     GFYALPEVIEDINRTNLDCLKYYGNVINCISINETSHVKINNFDIDLINNNPDRNITF
                     YVIKENEKKVIYACCNPKPFTHSDMYFDADVLIISLVSDDGILNDGTKLKDTPFKDEI
                     FTLDEIVEIKNYYRIKKIIITHIDEIWGKSYGYYSELEKKLDNIYFAYDGMEIIV"
     gene            complement(5399..6178)
                     /locus_tag="KR257_003625"
     CDS             complement(5399..6178)
                     /locus_tag="KR257_003625"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436810.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SDR family NAD(P)-dependent oxidoreductase"
                     /protein_id="HBH0032281.1"
                     /translation="MSYKKIAIITGANSGFGKEFLKLLINEEEITEIWAVARNKARLN
                     QLVDEFGSKVKIFSKDLSKIEEVKEIGTFLSKENVCIKYLINNAGFAKFCSYNDLSID
                     ESINMIDLNISAVVALGLICIPYMQKGSHIMNISSQASFQPLPYQNIYSSTKAFIRNY
                     TRALNVELKSKGINAIAVCPGWMSTNLFKRGIVVAEKGTKNFPGIVSPDIVAKKALKD
                     AKKNKDISVYGINTKSSHLLAKLLPQKMMMKVWLMQQHIKE"
BASE COUNT         2419 a          870 c          822 g         2301 t
ORIGIN      
        1 ataagaaatt atactaatga tacaaaaaaa gattctgtta gaggaactat tccttttgaa
       61 aaaatggaat ataagcgtcc taatatacag tcaatttgcg aaaacattaa caagtgtaac
      121 gacaaacttt taacagctaa aacagctaag gaacaattaa atttatttaa tgaagttgat
      181 aaaatttatc aggattttta cagtacactt actatagcaa aaattagaaa taacatagat
      241 tcatcagacg aattttactc taaggaatat aagtatctta tgagtaaatc agtagatgtt
      301 gacatgtcat acaaagactt tcaagataga tttgtaactt ctaaattctc taaagaatta
      361 gaaaaagaac ttggaaagga tacatttaat tatctaaaga acattggaaa acttaattct
      421 aaagaagttg aaggtttgct taaaaaagag caagacctag ttgtaaaata tgaagattta
      481 ttagctaaat ctacagtatc aatagatggt atagaggtag actttgaaga agccttgtca
      541 agaccaaatc ttagccctga agaatatgtg aaaatttatt cagattactt aaaaaaatac
      601 aatcctatat ttggtaacat attcttagaa cttatacaga caagaactga aatagcaagt
      661 aagcaaggat ttaagaatta tatagattat gcctatatga acctaaacaa agactattct
      721 caagaagaag ctaaaaaatt tagacaagat gtaaaagatt acatagttcc attatataga
      781 gagatttcat ctaaaccatc tgattcttct atttatatta aagtatataa aaatcgctca
      841 tttaggaagt ttgataaagt acttgaagat atatctccaa aactaaaaga gagcttcgac
      901 tatatgaaaa aatatgactt gtacgattat tcttctggaa aaaacaaatc acctggagga
      961 tatactactt atataaataa atataaagca cctttcttgt ttaatacatg ggacaattct
     1021 tttttaggtg ttactagttt tgctcatgag tttggtcatt tttataatta ctacaacagt
     1081 attaacttaa ataataagat gcaaccaagt atagatgtat gtgaagttca ttcaacatct
     1141 ttagaaattc tattttataa atattttgat gatttttttg gtaaacaatc tgaagctata
     1201 aaaaaagaac acttatcgat tgttttaaat actattattg atgcttgtct ttatgatgaa
     1261 tttcaagaaa ttatatacaa gaatccatat atgagtctaa atgatatcaa taaattgttt
     1321 tttgatttag aggaagaata tggagtttcc aataatatac ttagagaaaa aaatgctcct
     1381 ttttggatac ttgtatctca taacttccaa gttccttttt attacttgag ttatggtctt
     1441 gcatctgatg tatcacttca gatatggcaa ttatcacaag aagattacag aaaagctgtt
     1501 gatgtatata tggatttttt aaatcaaaat actgatgctg gatttaaaga tgtggtagaa
     1561 aaggtaaatt tacaattacc tttccaaaat ggaaatttag aggaaataag ctctacttta
     1621 tatgattatt ttggtataga taatccactt gaactaaaaa atgcttctta atttctaata
     1681 ctttatactc actcttaaga tttagtatta gattgaaata agtgatattt tttcacacac
     1741 aattaatgtt taataaaatt atatggtaaa gtatcagaaa tttttaagac tcttgtcttt
     1801 ataatttctg atactttatt tattaataat attattattt ttttatatat ataattaaaa
     1861 ggattgtgga aatcaataaa aatatccctg taaaaatagc actattcata tggaacttaa
     1921 tagaacttgc atctgttacc ttattattct taatccagaa cccacaaacc atagttgaaa
     1981 gaaaaagtaa aacagtgata agacttgaac caatagttat aattttcatc ttacatcaac
     2041 atcctctcca ataatatttt ctattaaaat atcaatgaat ttatctcgct catatttatt
     2101 ctttatattt ataccactgt ataactgaaa tgattctgta gataaagcag aaatctgtat
     2161 tggtaaaata atttgcaggg caatgattct tagactcatt tcatcttttt tatttccaaa
     2221 aattttacga agcataggga caatatcaag ttctgcttgc atatctccat tggttataca
     2281 ttgattcaat acaaaaggaa gcactttttc ataatgtaat ccagtatcac acaatttttt
     2341 taataaattt tttaaatctt caataggtct tagagtatat acactatcgt catatagctc
     2401 tgctattata tttgacatca catctcctat ggcagtactc aacaaattat cctttgtttt
     2461 aaaatgataa tttattaaac caactccaac atttgcacgc tcagcaattt ttctaactgt
     2521 aatctcctca atatcatcta cttcatttaa aagattcaat gtaacttcaa ttatacgttc
     2581 tctagcatct ttatcattac ttttcataat agacctccaa aacaattaac attttcggtt
     2641 ctgaacatgt ttagtataat atttttttca tcatatgtca atataattta attataattt
     2701 tagttgactc taacattatg atatggttta tattaatatt aagctaaaag tacctttata
     2761 aaggagacaa aaacatgttt aagataggcg atttttcaaa gctaagtaaa attagtattc
     2821 gtatgttacg tcattatgat gaaataggac ttttaactcc ttctcatacg aataaaacta
     2881 atggatatag atactatagt gcagaccaac tttctactac aaacagaatc catgcactaa
     2941 aagatatggg ctttggcttg tattctataa aagaaatttt gacagaatat aacgataaag
     3001 aaagtctcat aaaatatcta aatatccacc attctcaagt aaaagaacaa ttagaagata
     3061 cacagaaaaa actattaaaa atagaaacca ctattaaaag aattggagga aatgatatta
     3121 tgaaaaatta tgatgtaact ataaagaatt ttgcaccaaa atatatgatg acacttagaa
     3181 gggttatacc aacttaccaa gacgaaggaa tgttatggca tcaagtattt ttagagacaa
     3241 aagaccagaa tgttcaaatt gaacccccaa agtattctaa agcagttttt tatgatactg
     3301 gatataaaga agattatgta gatgttgaag tacaagttgc tgtatctgga aagtataaag
     3361 atactgaaca tgttaaattt aagactgttc caagtgtgac tgctgcaact gcaattgtta
     3421 atggaaattt caatcaagtt gcagacgctt gtgaggctat tggtaattgg atatcagata
     3481 ataactatga tgtggatggt cctatgttta atatttatca tgtaagccct ggcaacgata
     3541 gtaatcctga taattgggta acagaggtat gcttcccagt taaaaagaag taatttttat
     3601 attaattgga taatatttta atttgttaga caaattactt ttagtgttat gtataaatac
     3661 ctacaatttg attaggatat tatcttaatt tgttaaacaa attactttta gtgttatgta
     3721 taaatatcta caatttaatt aggatattat cttaatttgt cagataaatc aattataaga
     3781 ttatatacta tccttatact ctagttaaat atattttaat cactaatata aattagtttt
     3841 tttaacaaaa caataaaaga gtaaagtaca aataattcct ttgtgctcta ctctttttaa
     3901 ctttctttag acaataatac aatgataaat ataaaaaatt atatattcca ttctatagaa
     3961 atatgctcac caataacatg tatgttgtta atcaatatat tatatcaaat tatatcaaaa
     4021 ttacataaac cttataggac aatcatatct tattacaaga aaaatgtctt atccatattg
     4081 aataagtcat tcagttcata tacaaagtca atttcattga gaaacattta atatatgttt
     4141 ataaaaattt catactattc tttcatattt acatgtgata taatttatta actcataatt
     4201 ttgttaatca gttgtgattg tagattattt atataatcta atattttaag aaggtggtgt
     4261 aataactttg aaattaaaaa ttgttggtag tggcggtatg tcaattattc caagttcatt
     4321 ttgcaaatgc aaaatatgtg aagaagccag acaaaaaggc ggaagatatg aacgattagg
     4381 gccaagttta tatattgatg atataaaaat gctgatagac acacctgaag atattgcagt
     4441 agcttgtaac agacaaaaaa tatcggaagt aaaacatatt tcaatttctc accatgaccc
     4501 agaccatgtt aagggtatta gaattgtcga aaaaatagga tgtgacttta tcacaggaga
     4561 aaataatcca attggctttt atgcgcttcc tgaagtaatt gaagatataa accgaacgaa
     4621 tctcgattgt cttaaatatt atggtaatgt tataaattgc atttctatta atgaaacttc
     4681 gcatgtaaag ataaataatt ttgatattga tttgattaac aataacccag acaggaatat
     4741 aaccttctat gttatcaaag agaatgaaaa aaaagtcata tatgcctgct gtaatcccaa
     4801 gccatttact catagtgata tgtactttga tgctgatgtt ttaataataa gtctagtttc
     4861 tgatgatggt atattaaatg atggtacaaa acttaaagac acaccattta aagatgaaat
     4921 atttacttta gatgagattg ttgaaattaa aaactattat agaattaaaa agattatcat
     4981 tacacatatt gacgaaatat ggggaaaatc atatggttat tacagtgaat tagaaaagaa
     5041 acttgataac atttattttg catatgatgg tatggaaatt atagtctaaa tcattaagta
     5101 ataagcataa tgcaaaataa gaaaacttca atttaacagt atagttaaac tatgtaatat
     5161 caacatatct cagtttttac aaaatatcat agtatttatc tttataaaat ttcaagtcct
     5221 acatatttta atacttcaat atctaaataa agtaaaatca aaaatatatt ttatatacat
     5281 tatagacggc ttatcggcac tagataagcc gttttgtcac aattattatt tgctcaacaa
     5341 aacttctcat aatatataac agattgaatc tccaactgat acttaattac cgaaactctt
     5401 attccttaat atgttgttgc attaaccaaa ccttcatcat cattttttgt ggcaatagtt
     5461 ttgctaataa atgactggat tttgtattta taccatacac agaaatatcc ttatttttct
     5521 ttgcatcctt caatgctttt ttggcaacaa tgtctggaga cactatgcct gggaaatttt
     5581 ttgtcccttt ttcagctaca actatacctc tcttaaatag atttgtactc atccaacctg
     5641 gacatacagc aattgcattt atccctttac tcttaagttc aacatttaat gctcttgtat
     5701 aatttcttat aaacgcttta gttgaactat aaatattttg atatggcaat ggctggaatg
     5761 atgcttgtga agaaatattc atgatatggc ttcccttttg catatatgga atacatataa
     5821 gtcccaatgc tacaacagca ctaatattta aatcaatcat attaatagat tcatctatac
     5881 ttaaatcatt gtatgaacag aattttgcaa aaccagcatt gtttataagg tattttatac
     5941 atacattttc tttacttaaa aatgtaccaa tttcttttac ttcttctatt tttgataaat
     6001 cttttgaaaa aatttttacc ttacttccaa attcatctac taattgattt aatctcgcct
     6061 tgtttcttgc aactgcccat atttctgtta tttcttcttc atttattaat aactttagaa
     6121 actctttacc aaaaccacta ttagcacccg ttataattgc aatcttctta taactcataa
     6181 ttattctcct ttaccataag tttatacgct caaactgtaa acttattttt tacaaataaa
     6241 acaccctcta ttcagatgtt atattcatat tatttgagat attatattta tatcattttc
     6301 aataattgtt atatagcata aaaaatagtg ttaatattat agaatcggta ttgattatat
     6361 ttaaaaagta gtgttaatta tattatagaa tcggtattga ttatatttaa aa
//
LOCUS       DAEPID010000136         6387 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.137, whole genome shotgun sequence.
ACCESSION   DAEPID010000136 DAEPID010000000
VERSION     DAEPID010000136.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 6387)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6387)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..6387
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.137"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            230..1711
                     /locus_tag="KR257_003626"
     CDS             230..1711
                     /locus_tag="KR257_003626"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893314.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional diguanylate
                     cyclase/phosphodiesterase"
                     /protein_id="HBH0032282.1"
                     /translation="MKKNRLIAKNISIAFIVLFFFSVFTFFYVGNINRVLEYETNDII
                     TVTIAGWIILSFLFLGIIIYILYSKANSQKTIEKVAYTDFVTGYSNWRKFELDVTNLL
                     KKTSQNNKYAMVIFDIDKFKAINDIYGHKKGNLILKDIADTLNELTDINETFARVSAD
                     NFNILLTYNKKEDIINIIKKIMANNELVNLSFGIYEIKDKDLSVSVYSDRASLAKSSI
                     KNNSDVNFAFFNDKLREKLLFEDKIEKEMEYALESGQFVMYLQPKYNIKLDKFCGSEA
                     LVRWQYTEKEVIYPGDFIPIFEKNGFIRKIDMYILEQACKEIRSLFDKGISPLPISVN
                     FSRVDFFKKDFIENIVNICDRYKIPYSLIEIEITESSMFGDTDTLFNVSRNLQDIGFI
                     VAMDDFGSGYSSVNMLKNIPLNVIKLDRGFFVYDKDVDKSQIVIKSIVSLIKQLGIRV
                     VAEGIETRSQIEMLKKANCDIVQGYYFSKPLPIKEFEKLVYKI"
     gene            1744..5181
                     /locus_tag="KR257_003627"
     CDS             1744..5181
                     /locus_tag="KR257_003627"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423923.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PAS domain-containing protein"
                     /protein_id="HBH0032283.1"
                     /translation="MIRAKSLKNVLSIVLIFLFTIISFSDFAFKTNVQEEENSKINLR
                     EISLQSSNAIKIKLDSSLSFIKSVANMVSYFNTIDNSKIVPLLANISKESDFQRISIV
                     SPDGISHTSDGKIINVSKYQYFKKAIKGESNISEVVKSPIDGKDTFVIATPVFNKNNK
                     IIGVLYGSYYNDKLAEFIDITSFNSEGYIDIFESSGQFVLKSSHTNKLIKSSSNIYDI
                     FKKASFDDGYSYKKIYEDTKNNKSGFTSYEYKGENRYATYTPIGVNDWYVISVIPQYT
                     VRRNIDKINQLAFSLIFKVFLLFIMLITYIIYKNNKSQKDILKANKEISSITNSIPGG
                     VQKCTLGETCNINFLSDGFIELFGYTREEIKTLFNNDFYSLIHKDDVERIKKEIFKQL
                     YKNKTVELEYRIITKNGNTVWVLDKGELITEPDGKEYFCCVTVDITRTKQLEQEMEQK
                     NLELEMISENVLGGIIITEFNDDFTIKYANSGYLSMIGYTREQLENELKYKACNLVFY
                     EDRKKALESIQHQLNTKGIAVYQHRIRRRDGNIIWVSIKGRLIVDDDGIEKGIWILND
                     ITDLKNAEQKLKINEERFRIALKQTSNTIFEYDIKTKSLLNTSKELDKYNIYKITKNV
                     PYSLVELGVIHKDFSDDFINMYENVINGAKKASCVVKMKLPDENYIWNKVTLTTIFDE
                     DGNPVRAIGIQEDISKQKEAEIRYNQEGKYHSAILSEAMITYEINVSKDTFIKGNESW
                     QKPFGIKPDNNYSQMVKTIANSIVHKDNKETFLNTFLCENLLDAYKNNVTEIKLEYRR
                     MNQENKMIWVICTMHLIKDSITNDIKALAYVKDIDKQKNEEIRLKLKAERDTLTGLYN
                     KGTTEKLINDFLNSEEASLGMHAFLIVDIDNFKSVNDNLGHVFGDKVLFEVSKNLKPI
                     FRKDDIVGRIGGDEFIVFLKNIQSFENIKKKAEKICDIFRNSYTENKKTYKISGTVGI
                     SFVPEHGTVFEELYKKADIALYYAKSKGKDKYALYNDCIYQNELENNISDNNIKLADK
                     CEKSKPVLKEILDSIDNYIYIVNPNTYELLFVNNKVSRLDLEIKLGETCYKSLLKSDR
                     PCNNCPLNGLEENKHSKFKIETNTFGKNISIASWINCIDGEYNCLIECIDSSLYKNK"
     gene            5199..5945
                     /locus_tag="KR257_003628"
     CDS             5199..5945
                     /locus_tag="KR257_003628"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889797.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YdcF family protein"
                     /protein_id="HBH0032284.1"
                     /translation="MLNSITLILGIIFTIYYFYLKIVFGGISFSEIFLVVGIVLIIYQ
                     IFKKKIKEKKVFYRVLKIIISIFLIVFVVTESLIIFYPKNSLESKSDYLLILGASVKK
                     TTPSTTLKGRLDTALKYLKINDNCYVVVSGGKGSGEKITEAKAMKDYLIKNGIDKNRI
                     IEEDKSTNTYENFKYSKLKIEEHSQRKLSDLKVKIVTTDFHVLRSKILAYRNGYKNTS
                     FYASKSKLSFVPTYYTREFFALWKTIIFDR"
     gene            complement(5894..6202)
                     /locus_tag="KR257_003629"
     CDS             complement(5894..6202)
                     /locus_tag="KR257_003629"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003439404.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pyridoxamine 5'-phosphate oxidase family
                     protein"
                     /protein_id="HBH0032285.1"
                     /translation="MNFLKENSTFYFATVEDNKPRVRPFGFIMDYEGKLYFGIEKYKT
                     SYKQLLVNPNIEISTTSKVGKWIRIKGIEKTRYEFISSLFIYYLSKMIVFHNAKNSLV
                     "
BASE COUNT         2666 a          623 c          952 g         2146 t
ORIGIN      
        1 taagcgatag tgtatttaat tgtattaata aatatggatt caatataatt aaatatgcta
       61 ttgatatatt tgtaccctta actattgtta tcttttagat gataatgata tttatttaaa
      121 tactctttat taacaattta taaaacttaa ttgtaaaaaa tacttattaa tagtaaaata
      181 aagtgaatca attatattat aattgctaaa gagagtgagg tgtagctatt tgaaaaaaaa
      241 tagattaata gcaaagaata tatcaatagc atttatagta ctattctttt ttagtgtatt
      301 tacattcttt tatgtaggta atattaatag agtgttagaa tatgaaacaa atgacataat
      361 aacagttaca attgctggat ggattatact ttcattttta tttttaggta ttataattta
      421 catattatat tcaaaagcaa atagtcaaaa aactatagaa aaagtagcat atacggattt
      481 tgtaacaggt tattccaact ggagaaagtt tgaattagat gttacaaatt tattaaagaa
      541 aacatcacaa aataataaat atgcaatggt catattcgat attgataaat ttaaagcaat
      601 taatgatata tatggccata aaaagggaaa tttaatatta aaagatattg cagatacttt
      661 aaatgaattg actgatatca atgaaacttt tgctcgtgta agtgctgata atttcaatat
      721 attattaaca tataacaaaa aagaggatat aataaatatt atcaaaaaga ttatggcaaa
      781 taatgaactt gtaaacttat cttttggaat ttatgaaatc aaagataagg atttatctgt
      841 aagtgtatat agtgatagag cttcacttgc aaaatcatca ataaaaaata atagtgatgt
      901 aaattttgca ttttttaatg acaaattaag agagaaatta ttatttgaag ataagataga
      961 aaaagaaatg gaatatgctc ttgaaagtgg gcaattcgta atgtatttac aaccaaaata
     1021 caatattaaa ttagataaat tttgtggaag tgaagcccta gtcagatggc aatatacaga
     1081 aaaagaggtc atatatccag gtgattttat tcctatattt gaaaaaaatg gatttattag
     1141 aaagattgat atgtacatat tagaacaagc ttgtaaagaa atccggtctt tatttgataa
     1201 aggaatttca cctttaccta tatctgtaaa cttctcaaga gttgattttt ttaaaaaaga
     1261 ttttattgaa aacatagtaa atatatgtga tagatataaa ataccatata gtttaataga
     1321 aattgaaatt actgaatcta gtatgtttgg agatactgat actctattta atgttagtag
     1381 aaacctacag gatattggct ttatagttgc aatggatgat tttggctctg gatattcttc
     1441 tgtaaatatg cttaaaaata taccattaaa tgtaataaaa ttagatagag gattttttgt
     1501 ttatgataaa gatgttgata agagtcaaat tgttataaaa agcatagttt ctctcattaa
     1561 gcaattagga ataagggttg ttgctgaagg aattgaaaca agaagtcaaa tagaaatgtt
     1621 aaaaaaagca aattgtgata ttgttcaagg atattatttt tcaaaaccat taccaattaa
     1681 agaatttgaa aaattagtct ataaaatata gtcagcgagt cttaaatggg aggtggtgat
     1741 taagtgataa gagcaaaatc gttaaaaaat gtactgagta ttgttttaat atttttattt
     1801 acaataattt ctttttctga ttttgcattt aaaactaatg tccaggaaga agaaaatagt
     1861 aaaattaatt taagagaaat atccctacaa agttccaatg ctataaaaat aaaattagat
     1921 agttctctat cctttattaa aagtgtggca aatatggttt cttattttaa tactatagat
     1981 aactcaaaaa tagttccatt attagctaat atatcaaaag aatctgactt tcaaagaatc
     2041 tctattgtat ctcctgatgg aataagtcat accagtgatg gcaaaattat caatgtgtca
     2101 aagtatcagt attttaagaa agctattaaa ggagaaagta atatatctga agttgtgaaa
     2161 tctccaattg atggaaaaga tacttttgtt atagctactc ctgtatttaa taagaataac
     2221 aaaataattg gtgttttata cggttcttac tacaatgata aattagctga atttatagat
     2281 ataacaagtt ttaatagtga agggtacata gatatatttg aatctagtgg tcaatttgtt
     2341 ttaaaatctt cacatacaaa caaactgatt aagtcaagta gtaacatata tgatatattt
     2401 aaaaaagctt cttttgatga tggttatagc tataaaaaaa tatatgaaga tacaaaaaat
     2461 aacaagagtg gctttacctc atatgaatac aaaggagaaa atcgttatgc tacttataca
     2521 cccattggtg taaatgactg gtatgtaatt tctgtgatac cacaatatac tgtaagaaga
     2581 aacattgata aaataaatca attagcattt tctcttattt tcaaggtatt cttattgttt
     2641 attatgctta taacatatat tatttataaa aacaataaat ctcagaaaga tatactaaaa
     2701 gctaacaaag aaatctcatc tattacaaat agcattcctg gaggagtaca aaagtgtacc
     2761 ctgggtgaaa catgcaatat taatttttta agtgatggat ttatagagtt gtttggttat
     2821 acaagagaag aaataaaaac attgtttaat aatgattttt atagtttaat acataaagat
     2881 gatgttgaaa gaataaaaaa agaaattttt aaacaacttt acaaaaataa aactgttgaa
     2941 ttagaatata ggattataac aaaaaatggt aatacagtat gggttttaga taaaggggag
     3001 cttataacag aacctgatgg aaaagaatat ttttgttgtg taactgtaga tattactaga
     3061 acaaaacaat tagaacaaga gatggaacaa aaaaatctag aacttgaaat gatatcagaa
     3121 aatgttttag gtggtataat tataacagaa tttaatgatg attttactat aaaatacgct
     3181 aactctggtt atctttcaat gattggatat acacgtgaac aattagaaaa tgaacttaaa
     3241 tacaaagctt gtaatcttgt tttttatgaa gatagaaaga aggctcttga aagtatacaa
     3301 catcaattaa acacaaaagg aatagctgta tatcaacata gaataagaag aagagatggt
     3361 aatattattt gggtttctat aaaaggaagg cttattgttg atgatgatgg tattgaaaaa
     3421 ggtatttgga ttctaaatga tataacagat ttaaaaaatg cagaacaaaa acttaaaata
     3481 aatgaagaaa gatttagaat tgcattaaag caaacatcaa acactatatt tgagtatgat
     3541 ataaaaacaa agtcactttt aaatactagt aaagagcttg ataaatataa tatttataaa
     3601 attactaaaa atgttccata ttctctagta gaattaggag ttattcataa agattttagt
     3661 gatgatttta taaatatgta tgaaaatgta ataaatggag caaaaaaagc aagttgtgta
     3721 gttaagatga aacttccaga tgaaaattat atatggaata aagttacctt gactacgatt
     3781 tttgatgaag atggtaatcc tgtaagagca attggtatac aggaagatat aagcaaacaa
     3841 aaggaagcag agataagata caatcaagaa ggtaagtatc attcagctat attgtcggaa
     3901 gcaatgataa cttatgaaat aaatgtatca aaggatactt ttatcaaagg aaatgaaagt
     3961 tggcaaaaac catttggaat taagcctgac aataactatt ctcaaatggt aaaaactata
     4021 gcaaatagta ttgtacataa agacaataaa gaaacatttt taaatacatt tttatgtgaa
     4081 aacttattgg atgcatataa aaataatgtg actgaaataa aattagaata tcgaagaatg
     4141 aatcaagaaa ataaaatgat ttgggtcatt tgtacaatgc acttaataaa agattctatt
     4201 acgaacgata taaaagcact tgcttatgtt aaagatattg acaagcaaaa aaatgaagaa
     4261 attagattaa aattaaaagc tgaaagagat actcttacag gattatataa taaaggtact
     4321 acagaaaaat tgattaatga tttcttgaac tctgaggaag caagcttagg aatgcatgca
     4381 tttttaattg ttgatataga taattttaaa tctgtgaatg ataatttagg acatgtattt
     4441 ggagataaag tattatttga agtttctaaa aacctaaaac ctatatttag aaaagatgat
     4501 atagtaggta gaattggtgg agatgaattt atagtattct taaaaaatat tcagtctttt
     4561 gagaatatca aaaagaaagc agaaaaaata tgcgatatat ttagaaattc ttatacagaa
     4621 aataaaaaga catataaaat atctggaaca gttggaattt catttgtacc agaacatgga
     4681 actgtatttg aagaacttta taaaaaagca gacatagcac tttattatgc aaagagcaaa
     4741 ggaaaagata agtatgcact ttataatgat tgtatctacc aaaatgaact tgaaaataat
     4801 ataagtgata ataatataaa gttagcagat aaatgtgaga aatccaaacc agtacttaaa
     4861 gaaattcttg attctattga taattatatc tatatagtga atccaaatac ttatgaactt
     4921 ctttttgtca ataataaggt gtctcgtttg gatttagaga taaaattagg agaaacctgt
     4981 tataaatcac tattaaaatc tgatagacca tgtaataatt gccctcttaa cggattagaa
     5041 gaaaataagc attcaaaatt caaaatagag acaaatacat ttggtaaaaa tatcagtata
     5101 gcaagttgga ttaattgcat agatggagaa tacaactgtc ttatagagtg tatagattct
     5161 tctttataca aaaataaata aaaaaggact atgaagatat gttaaatagt ataactttga
     5221 tacttggtat aatatttaca atttactatt tttatctcaa aatagttttt ggaggaattt
     5281 catttagtga gattttctta gttgtaggaa ttgtactaat tatctatcaa atatttaaga
     5341 aaaaaattaa agaaaagaag gttttttata gggtgttaaa aataataatc agcatttttt
     5401 taatagtatt tgtagttact gagagtctaa ttatttttta tcccaaaaat agtttagaat
     5461 caaaaagtga ttatctctta attttaggag cttctgtaaa aaagactaca ccaagtacaa
     5521 ccctgaaggg taggttagac actgcattga aatacctaaa aattaatgat aattgttatg
     5581 tggtagtatc tggtggtaaa ggaagtggag aaaaaataac tgaggcaaaa gctatgaaag
     5641 attatcttat aaaaaatggt atagataaaa ataggataat agaagaggat aaatccacga
     5701 atacttatga gaattttaaa tattcaaaat tgaagataga agaacatagt caaagaaaac
     5761 taagcgattt aaaagtaaaa atagtaacaa cagattttca tgttctcaga agtaaaatat
     5821 tagcatatag aaatggatat aaaaatacgt ctttttatgc tagtaaatca aaactttcat
     5881 ttgtaccaac ttactataca agagaatttt ttgcattatg gaaaacaatc atttttgata
     5941 gataataaat aaaaagacta gatataaact catatctagt cttttctatt cccttaattc
     6001 taatccattt tccaacttta cttgttgtag aaatttcaat attgggattt acaagtaatt
     6061 gcttataaga agttttatat ttttcgattc caaaatataa ttttccttca taatccatta
     6121 taaatccaaa tggtcttact cttggtttat tatcttcaac tgtagcaaaa tagaatgttg
     6181 agttttcttt taaaaaattc attatttttt catgattaaa tcctctttgt atcttatact
     6241 aatataatga atataaataa aatattcatt atacttaata taaatcgata taaaaacaat
     6301 tacaatatta tattgattat tcgaaattat atataaaatt cagaaaaaat tttagtttac
     6361 ataacaaaaa taaagtcaac taaaatt
//
LOCUS       DAEPID010000137         6335 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.138, whole genome shotgun sequence.
ACCESSION   DAEPID010000137 DAEPID010000000
VERSION     DAEPID010000137.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 6335)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6335)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..6335
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.138"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            347..1621
                     /locus_tag="KR257_003630"
     CDS             347..1621
                     /locus_tag="KR257_003630"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003432037.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aminotransferase class V-fold PLP-dependent
                     enzyme"
                     /protein_id="HBH0032286.1"
                     /translation="MQFMDVSKYIEGANLKVKTKNGETVKRIYFNNSATPLVLKNVVD
                     NLNCEIPWLTYINAPGIISEKNTLKYENVRSTILKLIDGDEEKDSVIYVKNATEGINF
                     LAKFFKDENPDKFVITTAMEHMANYLPFKVNFPTKVVGITEKGELDLCQLENILKNYA
                     GNVSLVTVTGASNVTGITTPIYEIARIAHKYGAKILVDIVQVIQHKPFSMMPHECDEH
                     IDFVVFSAHKCYSPLNGGALVGPKKFFEKFNPVLYGSGSTKFVNDNKILYANVPQRFE
                     AGYPEYFGTLAMGKALNTLNKIGLNRISKYERELFLYAKEEMSKIPNIIIYGDKSNNV
                     IIPNISFNISNMYYKDVAKYLVDNFGIETGAGVVGADIYVQKLLGINPKEAYVRFMRE
                     NPVGLVRISLGMYNTFDEVDSFIHAIKTLAFK"
     gene            complement(1828..2145)
                     /gene="trxA"
                     /locus_tag="KR257_003631"
     CDS             complement(1828..2145)
                     /gene="trxA"
                     /locus_tag="KR257_003631"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004453775.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="thioredoxin"
                     /protein_id="HBH0032287.1"
                     /translation="MVKIINNNEFINEVENKDGLVVVDFFATWCGPCKMLSPIYEALG
                     NEMVEKANFLKVDIDQSIELAQKFEVSTVPTMLIFKDGKPVDRLIGFMPKENLKNKIE
                     SYM"
     gene            2412..3164
                     /locus_tag="KR257_003632"
     CDS             2412..3164
                     /locus_tag="KR257_003632"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003432043.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TrmB family transcriptional regulator"
                     /protein_id="HBH0032288.1"
                     /translation="MDNIINELQNIGFTKYESQIYISLLKESPLTGYEISKLSGVPQS
                     KVYENITKLLNNNIIINVGTDPIKYIPINPNELLKNKKKEFDNSMDNLKNSLQILNKS
                     KSVEYVLNIKGDKNILKKAIEMIKNAKQEIIISCPYEEILELKKELLIAYKKNINIEI
                     LLLENKSLKGLDNIHIHGGNKTTLENKMLYKGIILIVDNDEILTGNLSEGSEAISIWT
                     KNSNILYIGVQYIKHEIYISEQIKGGYKNEQN"
     gene            3151..4032
                     /locus_tag="KR257_003633"
     CDS             3151..4032
                     /locus_tag="KR257_003633"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003432046.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PhzF family phenazine biosynthesis protein"
                     /protein_id="HBH0032289.1"
                     /translation="MNKIKIKQVDAFTTIPFGGNPAGVVTDASNISDEIKQNVAKEMN
                     LSETAFVSESNIADFKVQFFTPGLEVDLCGHATIGTFHALLEEGKLNTNKSIFYQETK
                     AGVLSVELKKINNENIFMMEQNTPEFENLDNCRKELAQMIGVHEDRLLEYPIIKVNTG
                     LWWLVFGLKSLDDLKNISPDLNKIKKFSGDNNIIGITPFCIETIDKKCDYHLRSIAPY
                     VGVTEDPVCGTGNACVSSYIVHHNILDKTSFIGEQGNFINRPGKVYVNITRENNDITS
                     VKIGGSAYTILSGEIMY"
     gene            complement(4258..5613)
                     /locus_tag="KR257_003634"
     CDS             complement(4258..5613)
                     /locus_tag="KR257_003634"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004453772.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptide MFS transporter"
                     /protein_id="HBH0032290.1"
                     /translation="MSSTVKKKGKFPMGFYICSTTFSFERAAYYASKYLIYIFLTTAI
                     VHGGLGIDKGQAAIMQANLVAFTYLAPIIGGYISDRWIGARYTIPIGMLIMGVGYYLG
                     SIATTVSMVNAMIILVSIGTAFFKGNVSAVNGQLFDSQEELDTAFSVQYSFVNIGSFI
                     GTIAVGILYLKTFAKNGVLGFSQCFFIAAVLCVIGAIWFIYGWRFLGNAGKRPFKEGV
                     VAEKIEEKDKSPLTSMDKKRIWAIILISFFSVIFWVFWYLTYLAVYDYGAAFVNMNVG
                     GFDVPLAWFDSLNSLVCIVLGPVLGALWFKLASRPQGDMSLFKKTGLGLIFLGLAFLM
                     LVGAEFSRGVGAPETAKASILWIIMFGILLSLGEMLFSPLGNSFVSKYAPKKLLGVLM
                     GVWTFATFIAGKGYGYIYAFTLKFDMIKVYTIIPVILFVAAILLFLSDKTLSRLVEDD
                     K"
BASE COUNT         2428 a          920 c          810 g         2177 t
ORIGIN      
        1 ttctttacta tttttacaac tttattagtc atattcataa ttatttctaa ttagtgttta
       61 acattttatg taaaatttat aaaaaaatgt atataaatta aaataagtga ctatactaaa
      121 aatatgatac ggataaacaa taagttcaac ctatctcccc caaaatcaag tgagctacag
      181 tttcccccaa ctgtagctca ttttcgtgta atttaataaa catctcaaca agaattaatt
      241 aacaaaaccc cttataaaaa cataacatat attaaacaag ctcttgatta aaacttgagc
      301 ttttttaata aaaaacagaa tagtttatta gataaggggt ttttttatgc aattcatgga
      361 tgtatctaaa tacattgaag gtgcaaacct taaagttaaa actaaaaatg gtgaaactgt
      421 taaaagaata tattttaaca actctgccac tccattagtt ttaaaaaacg tagtggataa
      481 cttaaactgt gagattcctt ggcttactta tattaatgct ccaggaataa tctcagaaaa
      541 aaatacttta aaatatgaaa atgtacgctc tactatcctc aaacttattg atggagacga
      601 agaaaaggat tctgttattt atgtcaaaaa tgctacagaa ggaataaact tcttagcaaa
      661 attttttaaa gatgaaaatc cagataaatt tgttattacc acagcaatgg agcatatggc
      721 taattacctg ccttttaaag ttaattttcc tacaaaagtt gttggaatta cagaaaaagg
      781 agaacttgat ttatgtcaat tagagaatat acttaaaaat tatgctggta atgtatctct
      841 cgttacagtt acaggagcta gtaatgtcac aggtataacc actcctatat atgaaatagc
      901 aagaatagct cataagtatg gtgcaaagat attggtggat attgtgcaag taattcagca
      961 taaacctttt tcaatgatgc cacatgaatg tgatgagcat atagattttg ttgtttttag
     1021 tgctcataaa tgttattctc cactaaatgg aggagctctg gtaggaccta aaaaattctt
     1081 tgaaaaattt aatcctgtac tatatggctc aggttctacc aaatttgtaa atgataacaa
     1141 aatactatat gcaaacgtac cccaacgttt tgaagcagga tacccagagt attttggaac
     1201 tcttgcaatg ggaaaagcac tgaacacttt aaataaaatt ggtctaaaca gaatttcaaa
     1261 atacgaaaga gaattatttt tatatgctaa agaagaaatg agtaaaatac ctaatataat
     1321 aatatatgga gataaatcaa ataatgtaat tatcccaaat atatctttta atataagtaa
     1381 tatgtattac aaagatgtag caaaatattt agttgataac tttggaatag aaactggagc
     1441 tggagtagta ggtgcagata tttatgtaca aaaattatta ggtataaatc caaaagaggc
     1501 atacgtcaga tttatgaggg aaaatcctgt aggtcttgtt aggataagct taggaatgta
     1561 caatactttt gatgaggtgg atagctttat acatgctatt aaaactttgg cttttaaata
     1621 agatttttct attctttttt atcaataaat agagagtagt tttgttttca caaaaaaaca
     1681 aattatatca acagtcaatt tcattagcaa ttagacactc atttgtaact atacaaacta
     1741 ttttacacta tacaaacaaa aaactcatta caatgagttt ttttgtttat atatgagatt
     1801 tattttaatt acttcaattt actttaatta catatatgat tcaattttgt tttttaaatt
     1861 ctccttaggc ataaaaccta ttaatctatc tacaggtttt ccatccttaa atattagcat
     1921 agttggtact gtagatactt caaatttctg agctaattct atactttggt ctatgtccac
     1981 cttcaagaag tttgcttttt caaccatctc atttcctaaa gcttcatata ttggtgatag
     2041 catcttacaa ggtccacacc aagtcgcaaa gaaatctaca actactaaac catctttatt
     2101 ttctacttca tttataaatt cattattatt tattattttt accataatat acatctcctt
     2161 tattatcttc ttgatattaa tatactacgc cctatataac agttcaatta ggcacttttt
     2221 tgtaaccgcc tatttttaat agatttaata ttatgataaa tagatttata agattaaata
     2281 tttatgagac taaatatttc taatatattt tatttttttc ttaatatagt tgacattttt
     2341 tcccttaaat tataaaatca aattaataac tacataggta gttactaatc ttttatcaaa
     2401 ggagtttcta tatggataat ataattaatg aattacaaaa tataggattt actaaatacg
     2461 aatctcaaat atacatatca ttattaaagg aaagcccttt aacaggatat gaaataagta
     2521 aattatcagg tgtaccacaa tcaaaagtct atgaaaatat aacaaagcta ttaaacaata
     2581 atataattat caatgttgga actgacccta ttaagtacat accaataaac cctaatgaat
     2641 tattaaaaaa taagaaaaaa gaatttgaca attctatgga taatctaaag aatagcttac
     2701 agatattaaa taaaagtaaa agtgtagaat acgtattaaa cataaaagga gataaaaata
     2761 tattaaaaaa agcaatagaa atgataaaaa atgcaaaaca agaaattata atttcttgcc
     2821 cttatgaaga aattcttgaa ttaaaaaaag aactcctaat tgcttacaaa aaaaatatta
     2881 atattgaaat actactttta gaaaacaaaa gtctgaaagg tcttgataat attcatattc
     2941 atggaggtaa taaaactaca cttgaaaata aaatgcttta caaaggaatt attttgattg
     3001 tagataatga tgaaatattg acaggaaact tatcagaagg cagtgaggcc atttcaattt
     3061 ggacaaaaaa ctctaacatt ttatatattg gagttcaata cataaaacat gaaatttata
     3121 tttcagaaca aataaaagga ggttataaaa atgaacaaaa ttaagattaa acaagttgat
     3181 gcttttacaa ctataccttt tggtggaaat cctgctggtg tcgttactga tgcctctaac
     3241 atttctgatg aaattaagca gaatgtggct aaagaaatga atttatcaga aactgcattt
     3301 gtttcagagt caaatattgc agattttaaa gtacaatttt tcacaccagg tttagaagtt
     3361 gatttatgtg gtcatgcaac aataggtact ttccatgcac ttttggaaga agggaagctt
     3421 aatactaata agagtatatt ttatcaagaa acaaaagctg gtgtattatc tgtagagctt
     3481 aagaaaataa ataatgaaaa tatatttatg atggaacaga atacacctga atttgaaaat
     3541 ttagataatt gcagaaaaga acttgcacaa atgataggtg tgcatgaaga tagacttctt
     3601 gaatatccta ttataaaggt aaatactgga ctttggtggc ttgtatttgg tctaaaatct
     3661 ttagatgatt taaaaaatat ctctccagat ttaaataaaa tcaaaaaatt tagtggtgat
     3721 aataatataa ttggtataac tccattttgt atagaaacta tagataaaaa gtgtgactac
     3781 catttaagat ctatagcacc atatgttgga gttacagaag accctgtatg tggaactggg
     3841 aacgcttgcg tatcatctta tatagtacat cacaatattt tagataaaac tagttttatt
     3901 ggtgagcaag gtaactttat aaacagacct ggaaaggtat atgtaaatat aactagagaa
     3961 aacaatgaca taacttctgt aaaaattgga ggaagtgctt atactatttt aagtggtgaa
     4021 attatgtatt aatcccatac ctaataaaaa caaataaaaa tactagctaa ctaaagctag
     4081 tatttttatt tgttattttt atttaataat catactctaa caaatattat aattatatat
     4141 atcataatat tgtatttaga agtaaaattt tatttttatt attaattagt tataaatcaa
     4201 tctaatacaa cataattaca gtagattaac ctataaaaca taataattgc ttactaatta
     4261 tttatcatcc tcaacaagtc tacttaatgt cttatcagat aagaataata atatcgctgc
     4321 aacaaatagt attactggaa ttatagtata tactttaatc atatcaaatt taagagtaaa
     4381 tgcatatata tatccgtatc ctttaccagc tataaaagta gcaaatgtcc atactcccat
     4441 aagaacacct agaagcttct taggtgcata cttacttaca aaagagttac caagtggtga
     4501 gaataacatt tcaccaagac ttaaaagaat accaaacatg attatccata gtatactagc
     4561 tttagcagtt tcaggagctc caacccctct tgaaaattct gcaccaacaa gcattaagaa
     4621 tgcaagacct aagaatatta atccaagacc tgtcttttta aataaactca tatctccttg
     4681 tggtctacta gcaagtttaa accataatgc tccaagaact ggtcctaata ctatacatac
     4741 aagtgaattt aatgagtcaa accaagcaag aggaacatca aatcctccaa cattcatgtt
     4801 tacaaatgct gcaccataat cataaactgc aagataagtt agataccaga atacccagaa
     4861 aattacagag aagaatgata taagtataat agcccaaatt ctcttcttat ccatgcttgt
     4921 aagaggagac ttatcttttt cttcaatttt ttcagcaact acaccttctt taaaaggtct
     4981 ctttcctgca ttcccaagga atctccatcc atatatgaac catattgcac ctattacaca
     5041 aagtacagct gctataaaga aacattgaga aaatccaagt acaccatttt ttgcaaatgt
     5101 tttaaggtaa agaataccaa ctgctatagt accaataaaa gaacctatat taacaaaaga
     5161 atactgtact gaaaatgctg tatcaagttc ttcttgacta tcaaaaagct gtccatttac
     5221 cgcagatacg ttacctttaa agaatgcagt accaattgaa actaagatta tcattgcatt
     5281 taccatagaa actgtagttg caatagaacc aagatagtat cctactccca tgataagcat
     5341 acctataggt atagtatatc tagctcctat ccatctatct gatatatatc ccccaattat
     5401 aggtgcaagg tatgtgaatg caacaaggtt ggcttgcatt atagcagctt gtcctttatc
     5461 tattccaaga ccaccatgaa ctatagctgt tgtaaggaat atatatatta agtactttga
     5521 agcataatat gctgctcttt caaatgagaa agttgttgag cagatataaa atcccatagg
     5581 aaatttaccc ttctttttta ctgttgagct cataatttta aatcctttct taattgtatt
     5641 tttatttttt acgttttgtc caaattcttt cttttatgaa agatataata ttattatttt
     5701 gtaaaacaat ttgtaattat tattaagata attgcgcatt tatttgtaga gtacatattc
     5761 tcatggaata aaattaatac acttcttaat cataaattta aattatataa attcactatt
     5821 ttcagatata gttataaatt aatatattct catctaatac catgaaaaaa ccttcgccat
     5881 atgcaattct tattttttac gtgatagtat tttacaaact aaaatccccc ttttgtagca
     5941 acttatgtaa ttacatttta gtgctttttt aaaggagtct cgaataaagc aacatatatt
     6001 ttgttcaaat aatgttttta tttatttttt aaatttatat attacttcac tcaaccaatt
     6061 ctcaacttaa ataactaaac tactatctat tcacagatta ggcttatttc ttacacatta
     6121 gtttataata aacactgtga atctaaacat aaaaactgtt attttaaagt aattacccat
     6181 atattcgctt tgatactatt tattgaggtt atactcttta tgtataatat attatttata
     6241 aaatacctca aaatatatta ttcataaaat acctcaaact gaaaactttt tcacgaatat
     6301 ttatttttca cctccccttt tttatttcac catgt
//
LOCUS       DAEPID010000138         6152 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.140, whole genome shotgun sequence.
ACCESSION   DAEPID010000138 DAEPID010000000
VERSION     DAEPID010000138.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 6152)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6152)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..6152
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.140"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            206..886
                     /gene="pgmB"
                     /locus_tag="KR257_003635"
     CDS             206..886
                     /gene="pgmB"
                     /locus_tag="KR257_003635"
                     /EC_number="5.4.2.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430507.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="beta-phosphoglucomutase"
                     /protein_id="HBH0032291.1"
                     /translation="MIEAFIFDLDGVITDTAYYHYMAWRKLAHKVGIDIDTKFNESLK
                     GISRMESLDRILEFGNKKYSFSEEEKVRMAEEKNNYYVSLIDEITSNDILPGIESLLI
                     DVKSNNIKIGLSSASKNAINVLNHLGISDKFDFIADAGKCKNNKPHPEIFLMSAKGLN
                     VNPQNCIGIEDASAGIDAINSANMFSVGVGNYENLKKANLVVDSTNQLKFEYIQEKYN
                     EYIVRRII"
     gene            883..3168
                     /locus_tag="KR257_003636"
     CDS             883..3168
                     /locus_tag="KR257_003636"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861487.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycoside hydrolase family 65 protein"
                     /protein_id="HBH0032292.1"
                     /translation="MKCLFSNVDEWKIIQDKIEIKENRLAESIMSIGNGYMGMRGNYE
                     ENYSGDTHKGSYIAGVWFPDKTRVGWWKNGYPEYFGKIPNSVNYIGVRIFIDDVELDL
                     AKCKVEDFYRELDMKNGILNRRFIVNINDKKFEVRVARFLSISVKELAVIKYSIKSLN
                     SNTKIKFVPYLDSNIKNEDSNYEEKFWNGISSSSLEYKGSILSRTKENAFNTPVFTVG
                     SMMYIKTNGDVEAVSHESDYNYCENSITMDVLKNEVASIEKYVSITSTRDYKESELLR
                     KCEDILNRELSKSYDDILNEHTKLWNKRWESADVKINGDKSSQQGIRYNLFQLFSTYY
                     GEDSRLNIGPKGFTGEKYGGATYWDTEAFCVPVYLGVADKEVTRNLLEYRYNQLEQAK
                     DNAKKLGLKGALYPMVTFDGVECHNEWEITFEEIHRNGSIVYAIYNYTNYTGDYKYIK
                     EKGIDVIIEIARFWASRVHLSTKKDLYMIHGVTGPNEYENNINNNWYTNYIAKWCLDY
                     AVENILRLEKECNECIDRNNVTREEVEFWKIISNKMYLPYDEELQIIIQNDNFLDKEF
                     VEVKDLPKENFPLNQNWSWDKILRSCFIKQADVLQGIYYFGNRFTKEEKKRNFDFYEK
                     YTVHESSLSSSIYSIIASEIDNLEKAYELYSRTARLDLDNYNNDTNDGLHITSMSGSW
                     LSIVHGFAGMRTWNETLSFDPKLPKEWKNYSFNINYRDNIINVDVCSDLIKIENLKGR
                     PIKIIVYGKKYILEKCIKIDK"
     gene            3393..4286
                     /locus_tag="KR257_003637"
     CDS             3393..4286
                     /locus_tag="KR257_003637"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430511.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glucosaminidase domain-containing protein"
                     /protein_id="HBH0032293.1"
                     /translation="MKNKKFIVIILIISILIGVLVKEYSSREIKKDDINVSKYIKYAD
                     LASKNNAQVNWKYVASIVAVLNKNNLKNVKDSQIQEVSDLFVKNFSKNNKINKLSDIL
                     DELEFSNRQKRLVDNYIDNLKDYGIKPERLKSDTKYMKFIDEIKTEAIQNYKDYKILP
                     SITIAQAIIESSWGKSTLAKQYSNLFGIKADAYWKGKSVTLETKEHLDTIIDDKFRIY
                     DDKNESIKDHAKFLATNKRYKNNGVFDAKTYIYQAKALEKAGYSTAKDENGNSIYAAR
                     LIELIQQYNLQLIDSEIQSEM"
     gene            4723..5214
                     /locus_tag="KR257_003638"
     CDS             4723..5214
                     /locus_tag="KR257_003638"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861486.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0032294.1"
                     /translation="MYENNKVIYNLERCEKLEKTLYLSQFNTYKNFKLASKKTVINSL
                     ETYVYNMNINNISLVDTIECISLEDEQLTGKKLILVGDIDIDAILDYAGNKRNRNSSK
                     KNTFKLKIPFSTFIQMPRKIENKDKINLKYLIQDITSSILDDNLFISVTAIISYENSS
                     KIE"
     gene            5242..>6152
                     /locus_tag="KR257_003639"
     CDS             5242..>6152
                     /locus_tag="KR257_003639"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890361.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0032295.1"
                     /translation="MRITKTTFNDVFSSDANESIIKVEKYVDKKCASVFEILTYTIIV
                     TNTNRYKTGNIFFKDYISKYIEFINNTVKVNGIIKRGLDPQQGFYIGRIDASCKKIIS
                     FKSVVLPNSAHRIIKNSANIYYYYKCNLDKFPTRISIESNRVYTNVNKIVFKQLNISN
                     TLKAPKNLRDILKVNVNSKIFDVKPMKNLINKGSNLKLCNLIVFGCIEVEIDYSCKNR
                     SNFKTVNKSNDIKKDKYYKNDIQNNNENINDCKKQISFGDNKVKKITKTFGFSCFICS
                     PVGIIYEDMKNINIKIEHTSINELNPE"
BASE COUNT         2610 a          540 c         1011 g         1991 t
ORIGIN      
        1 tagatttcat gttaaattat tatacagttt aaataagtct ttataaacga taaaaaaata
       61 tggtctacaa gtgagtgaat tgaaagtaga ttttaaatta aagactgagt tagagtagat
      121 aattttataa ataatatctt aaatacaaga tagaaaataa attgattatt agtctaaaaa
      181 tttcttgtag aaagaggaaa taagaatgat tgaagcattt atatttgatt tagatggtgt
      241 aattacagat actgcatatt atcactatat ggcttggaga aaactagccc ataaagttgg
      301 gatagatata gacacaaaat ttaatgaatc tttaaaaggc ataagtagaa tggagtcatt
      361 ggacaggata ttagaatttg gaaataagaa atattcattt tcagaagaag aaaaagtgag
      421 aatggctgaa gaaaaaaata attactatgt atcattgata gatgagataa cttcaaatga
      481 tattttgcca ggtatagaaa gcttgttaat tgatgtaaaa tctaataata taaagatagg
      541 tctatcttct gcaagtaaga atgcaataaa tgtattaaat catttgggta taagtgacaa
      601 atttgatttt atagctgatg caggaaaatg taaaaacaat aaaccacatc cagagatatt
      661 tcttatgtca gcgaaagggc ttaatgtaaa tccacaaaat tgtataggga tagaggatgc
      721 aagtgcaggt atagacgcta taaactcagc taatatgttt tctgttggtg ttggaaatta
      781 tgaaaactta aaaaaagcaa atttagttgt agattcaaca aatcaattaa agtttgaata
      841 tatacaagaa aagtataatg agtatatagt taggagaatt atatgaaatg tttatttagt
      901 aatgtagatg agtggaagat tatacaagat aagattgaaa tcaaagaaaa tagattagca
      961 gagtccataa tgagtatagg caatggatat atgggtatga gaggaaacta tgaggaaaat
     1021 tatagtggag atacacacaa ggggtcttat atagctggag tatggtttcc agataaaact
     1081 cgtgttggtt ggtggaaaaa tgggtatcca gaatactttg gtaaaattcc taattcagtc
     1141 aactatatag gtgtaagaat tttcatagat gatgtagaat tagatttagc aaaatgtaaa
     1201 gtagaagatt tttatagaga attagatatg aaaaatggta ttttaaatcg taggtttatt
     1261 gtaaatataa atgataaaaa atttgaagtt agggttgcta ggtttttaag tatatctgtt
     1321 aaggaacttg cagtaattaa atacagtata aaatcattaa attctaatac taaaataaaa
     1381 tttgtaccat atttagattc aaatataaaa aatgaagatt caaactatga ggaaaagttt
     1441 tggaatggaa tttcttcaag ttctttagaa tataaaggta gtattctttc tcgaacaaag
     1501 gagaatgcat ttaatacacc agtattcact gtgggttcaa tgatgtatat taagacaaat
     1561 ggtgatgtag aagctgtatc tcatgagagt gattataatt actgtgaaaa ttcgataaca
     1621 atggatgttt taaaaaatga ggttgcaagt atagaaaaat atgtatctat aacttcaact
     1681 agagattata aggaaagtga gctattaaga aaatgtgaag acattttaaa tagagaacta
     1741 tctaaaagtt atgatgatat attaaatgaa catacaaagt tatggaataa aagatgggaa
     1801 agtgcagatg taaaaataaa tggagataaa agtagccaac aaggtataag atataattta
     1861 ttccaactat tttcaacata ttatggagaa gattcgcgat taaatatagg tccaaaagga
     1921 tttactggtg aaaagtatgg aggagctact tattgggata cagaagcgtt ttgtgttcca
     1981 gtatatctag gtgtagcaga taaggaggta actagaaatc ttttagaata taggtacaat
     2041 cagttagaac aggcaaagga taatgcaaaa aaactagggc ttaaaggtgc tttatatcca
     2101 atggtaacat ttgatggagt agaatgtcat aatgaatggg agataacatt tgaggaaatc
     2161 caccgaaatg gaagtatagt atatgcaata tataactata caaattatac aggtgactat
     2221 aaatatataa aagaaaaagg aatagatgta ataatagaaa tagctagatt ttgggcaagt
     2281 agagttcatt tgtctacaaa aaaagatttg tatatgatac atggagtaac aggtccaaac
     2341 gagtatgaaa acaatatcaa taataattgg tatactaatt atatagctaa atggtgttta
     2401 gattatgctg tagaaaatat cttacgatta gagaaagagt gtaatgaatg tattgacaga
     2461 aataatgtga ctagggaaga agttgagttt tggaaaataa tatcaaataa aatgtatctg
     2521 ccgtatgatg aggaactaca aataataatt caaaatgata attttttaga taaagaattt
     2581 gtagaagtaa aggatttacc aaaagaaaat tttcctctta atcaaaattg gtcttgggat
     2641 aagattctta ggtcgtgttt tataaaacaa gcagatgtat tacagggaat ttactatttt
     2701 ggaaatagat ttactaaaga agaaaaaaag agaaattttg acttctatga aaaatatact
     2761 gtacatgaat cttctttatc ttctagtatt tattctatta ttgcctcaga aatagataac
     2821 ctagaaaagg cttatgaatt atattcaaga acagctaggc ttgatttaga taattacaat
     2881 aatgatacaa atgatggact gcacataact tcaatgtctg gttcatggct ttccattgta
     2941 catggatttg caggcatgag aacatggaat gaaactctat cttttgaccc taagttgcca
     3001 aaagagtgga aaaattattc tttcaatata aattatagag ataatattat taatgtagat
     3061 gtatgtagtg atttaattaa aatagaaaat ttaaaaggta gaccaataaa aattattgta
     3121 tatgggaaaa aatatatatt agaaaaatgt ataaaaattg ataaatagat ttaataatat
     3181 ttttattata taaatagtta aaataagcta tctaattatt tatttatttt aactattttg
     3241 tgtgatagaa aactatatat tataacaata gtagtgcttt taattaaata tatttcataa
     3301 atcttcataa aatcttcaaa atttcgtaaa gaatatgtca caaaagtaag gtatattata
     3361 ttcagcagat agtataaggg aggacaatat ttatgaagaa taaaaaattc attgttataa
     3421 tactgataat atcaatttta ataggtgtat tagtgaagga atattcatct agagagataa
     3481 aaaaggatga tataaatgtc agtaagtata taaaatatgc tgatttagca agtaaaaata
     3541 atgcacaagt taactggaag tatgtagctt ccattgttgc tgtgttaaat aaaaataact
     3601 taaaaaacgt taaggattca cagatacaag aagtatcaga tttatttgtt aagaattttt
     3661 ctaaaaataa taaaataaat aagttaagtg atattttgga tgagttagaa tttagtaata
     3721 gacaaaaaag attggttgat aattatatag acaatcttaa ggattatggt ataaaaccag
     3781 aaagattgaa gtctgataca aaatatatga agtttattga tgaaattaaa acagaagcaa
     3841 tacaaaatta taaggattat aaaatacttc catctataac tattgcacaa gctataatag
     3901 aatctagctg gggcaagtca actttggcaa aacaatatag caatctattt ggtataaagg
     3961 ctgacgctta ttggaaaggt aagtcagtga ctttagaaac gaaagaacat ttagatacaa
     4021 ttatagatga taaatttaga atatatgatg ataaaaatga atctataaaa gaccatgcaa
     4081 aatttttagc cacaaataaa aggtataaaa acaatggtgt atttgatgca aaaacgtata
     4141 tatatcaagc taaagcatta gaaaaggcag gttatagtac tgcgaaggat gaaaatggca
     4201 atagtatata tgcagctcgt ctaatagaat taattcaaca gtataatctt caattaatag
     4261 acagtgaaat tcaaagtgaa atgtaacttt gattaaattt ttattgataa ggctatgatt
     4321 tttaaaatca tagccttatt ttgacatgct tttacttgta attattaaat cgatatcatt
     4381 atctttcaaa atttacttta tactgtaaat caaattattt aagttaaaac ttggaattat
     4441 ttataaaagg attatttact ttatctaaat tctgcactta aagaacatct tttcccttaa
     4501 gactgaccgt tagtctataa aaattataat tacttataaa aaagtgaata tatatataaa
     4561 gttttcagaa agacttttac ttgtaaattg aaatcaatga agtaaaaaag gattctttct
     4621 taaaagtaaa taacaactag atagtgaata ataaaaaatg gtaatttgaa ataattttta
     4681 tgaatagtat taatatatag atacagggag attgatgcga ttatgtatga aaataataag
     4741 gtaatataca accttgaaag atgtgaaaaa ctagaaaaga ctctttattt atctcaattt
     4801 aatacatata aaaattttaa attagcttct aaaaaaactg taataaattc attagagaca
     4861 tatgtttaca atatgaatat taacaatata agtcttgttg atactataga atgtatatca
     4921 ttagaagatg aacaacttac aggaaagaag ttgattttag ttggtgatat agatattgat
     4981 gcaatattag attatgcagg aaataaaaga aatagaaatt ctagtaaaaa aaatacattt
     5041 aaattaaaaa taccctttag tacatttata caaatgccta gaaagataga aaataaagat
     5101 aaaattaatt taaagtatct tatacaagat attacttcat ctattttaga tgataattta
     5161 tttattagtg ttactgcaat tataagttat gaaaatagtt ccaagataga gtaatcttta
     5221 aattatagaa aggtggatgc aatgagaata acgaaaacta cttttaatga tgtattttca
     5281 agtgatgcaa atgaaagtat tataaaagta gaaaaatatg ttgataaaaa atgtgcatct
     5341 gtatttgaga ttttgaccta cactattatt gttacaaata caaataggta caaaactgga
     5401 aatatatttt tcaaagatta tatttctaaa tatatagagt ttataaataa tactgtaaaa
     5461 gttaatggca ttataaaacg tggattagac ccacagcaag gtttttacat agggagaata
     5521 gatgcaagtt gtaaaaaaat aatatctttt aagagtgtag ttttaccaaa ttctgcacat
     5581 aggattataa agaatagtgc taatatatac tattattata agtgtaatct agataaattc
     5641 ccaacaagaa tatcaataga aagtaataga gtttatacta atgtaaataa aattgtattc
     5701 aaacaattga atataagtaa tactttaaaa gctcctaaaa atctaagaga tatattaaaa
     5761 gtaaatgtaa atagtaaaat atttgatgtt aaacctatga aaaatcttat aaacaaaggt
     5821 agtaatttga aattatgtaa cttgatagtt tttgggtgta tagaagttga aatagactat
     5881 agttgtaaaa ataggagtaa ttttaaaaca gtaaataagt ctaatgacat taaaaaagat
     5941 aagtattata aaaatgatat acaaaataac aatgaaaata taaacgattg taaaaagcaa
     6001 ataagttttg gtgataataa ggtaaaaaaa ataacaaaaa cttttggatt ttcttgtttc
     6061 atttgttctc cagttggaat tatttatgaa gatatgaaaa atataaatat aaaaattgaa
     6121 catacatcaa taaatgaatt aaatccagaa ga
//
LOCUS       DAEPID010000139         6068 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.141, whole genome shotgun sequence.
ACCESSION   DAEPID010000139 DAEPID010000000
VERSION     DAEPID010000139.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 6068)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6068)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..6068
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.141"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            complement(291..2123)
                     /locus_tag="KR257_003640"
     CDS             complement(291..2123)
                     /locus_tag="KR257_003640"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003433862.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBH0032296.1"
                     /translation="MSRMGRGPMGKSMGAGQKANDFKGTMRKLIAYLSKFKISIILVI
                     VFAIGSASFSIVGPKILGKATTKIFEGLVSKVSGGNVGIDFNAIGKILTFLLFLYLIS
                     ALFSFIQGFIMSGISQKVSYNLRKEISAKLDRLPMKYFDTKTHGEILSRITNDIDTLN
                     QSLNQSMTQLITSVTTMIGVLIMMLSISGIMTLVAVLILPISMFVISRIIKKSQKYFR
                     YQQEYLGNVNGQVEETYSGQTIVKAFNREDEVIEEFDKLNDSLYNSAWKSQFLSGIMQ
                     PLMMFIGNLGYVMVSILGGWLAIKKTIEVGDIQSFIQYVRNFTQPMTQIAQVANLLQS
                     TAAASERVFEFLEEEEEVQIVENAVSIDGLEGKIDFENVNFGYNPNKTIINDFSVNVE
                     PGQKVAIVGPTGAGKTTIVKLLMRFYDVNSGSILIDGHNIKDFNRSELREMFGMVLQD
                     TWLFSGSIMENIRYGKLNATDEEVIEAAKSAHVHRFIKTLPDGYKMKLNEEASNVSQG
                     QKQLLTIARAILADPKILILDEATSSVDTRTEVLIQKAMDNLMEGRTSFVIAHRLSTI
                     RDADMILVMNEGDIVEQGNHEELLKKGGFYANLYNSQFEEDEAM"
     gene            complement(2116..4362)
                     /locus_tag="KR257_003641"
     CDS             complement(2116..4362)
                     /locus_tag="KR257_003641"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011009877.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBH0032297.1"
                     /translation="MFKLIKYLKKSALSIVIIVCLLVIQAVCDLSLPEYTSNIVNVGI
                     QQGGVENSVPSVIRESELNKITLFMDKSSKDKVLDNYTLLNKKDYVKYKDKYPGLKDE
                     SLYELNTKDKDTIDDLNVIFGKAILIVSGLEGDSKEVKAMKAQLMSKLPPQATQSGDV
                     DIFKLLSAMPKEQLDTLTKEMSKGFESMPESMITQSSVSYVRSEYEKIGIDTEKTQNN
                     YILFTGAKMLGIAMISMVATITVGFLAARVAASVGRNLRSGVFRKVMSFSNTEMNEFS
                     TASLITRSTNDIQQIQMLMVMLLRIVFYAPIMAIGGVIKVLNTNTSMAWIIAVAVVAI
                     LSLIVVLFSVVMPKFKLVQKLVDKLNLVSREIITGIPVIRAFSTEKHEEERFDKANKN
                     LTKTNLFVNRVMTCMMPAMMLIMNLITVLIVWRGAYSVDSGAMQVGDMMAFIQYTMQI
                     IMSFLMISMVSIMLPRASVSATRIDEVLVSDISIKDPEKSEAQEFKEDKKGLVEFKNV
                     SFMYPDAEEPILTNISFTAKPGETTAFIGSTGSGKSTLINLIPRFFDVTEGEILLGGV
                     NIKNVSQHDLREKIGYVPQKGVLFSGTIESNLKYGRKDATDEEMRTAAEIAQATEFID
                     SKPEAFKTEISQGGTNVSGGQKQRLSIARAIAKNPEVYIFDDSFSALDLKTDAALRKA
                     LKSKTAESTVLIVAQRISTILNAEQIIVLNEGEIVGIGTHKELLKNCEVYEQIALSQL
                     SKEELANE"
     gene            complement(4430..4891)
                     /locus_tag="KR257_003642"
     CDS             complement(4430..4891)
                     /locus_tag="KR257_003642"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729095.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MarR family transcriptional regulator"
                     /protein_id="HBH0032298.1"
                     /translation="MNSNSEEKLNDVFLQLMRIYFIRTHFYFDKLGLYHGQPQILFSL
                     KMKDGQSQKELADKRKVKASTTTVMIKRMEKAGLVERKQDEKDQRVSRIFLTDKGLEI
                     CNKVEEFNKELEREFFLGFSEEEKIVLRRLLMQVRDNLKAGCHKHEDEKYF"
     gene            complement(5196..5762)
                     /locus_tag="KR257_003643"
     CDS             complement(5196..5762)
                     /locus_tag="KR257_003643"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423380.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="carbonic anhydrase"
                     /protein_id="HBH0032299.1"
                     /translation="MRKLEEILEYNKSFVENKEYEQYVTSKHPNKKIVVLSCMDTRLT
                     ELLPKAMNLKNGDVKLIKNAGATIMHPFGSIMRSVLVAIYEFDVDEVMVVGHHGCGMC
                     NVDTDKLLGKILDRGISNDVILTLRSAGIDTKQWLHGFDSAEESVKDSIDLIKGHPLI
                     PDGIIVHGLIISPETGKLDVVVNGYEDK"
BASE COUNT         1948 a         1104 c          641 g         2375 t
ORIGIN      
        1 attaaattct atttataata aaatttaaag aataaaatta aatatacatt ttgataatca
       61 cctccaacat tttccttact acatattata ataaaataaa cactttgtaa agacataaaa
      121 ttatgtggct atctcaaaat atagagaatc ctctttttca ttgttaaaat gataaaaata
      181 cactttattt catacacaaa agagtgcctt atgaattaaa aagttcattt taaggcaccc
      241 tcatttattt tatcttatta attacatgtc tatgctaaga tagttttttg ttacattgct
      301 tcatcttctt caaattgaga attgtaaaga ttggcataga atccgccttt ctttagaagt
      361 tcctcatgat ttccttgttc aactatatct ccttcattca ttacaagaat catatcagca
      421 tcacgtatag ttgataatct gtgggctata acaaaacttg ttctaccttc cataagatta
      481 tccatagctt tttgaatcaa tacttctgtt ctagtatcga cagaacttgt agcttcatct
      541 aatattaaaa ttttaggatc agctaaaata gcacgagcta tagtcaataa ttgtttttga
      601 ccttgagaaa cattacttgc ttcttcattt aatttcatct tatatccatc tggtaatgtc
      661 ttaataaatc tatgaacatg tgcagattta gcagcctcta taacttcttc atctgtagca
      721 ttcaacttac catatcttat attttccata attgaaccac taaataacca tgtatcttga
      781 agaaccatac caaacatttc tctaagctca ctacgattaa aatctttaat attatgacca
      841 tcaatcagta ttgaaccgct attaacatca taaaatctca ttaacagttt aactattgta
      901 gttttacctg ctcctgtagg tccaacaata gcaacttttt gaccaggttc aacatttact
      961 gagaaatcat ttattatagt cttgtttggg ttatatccaa agttgacatt ttcaaaatca
     1021 attttacctt ctaaaccatc tattgaaact gcattttcaa caatttggac ttcttcttcc
     1081 tcttctaaaa actcaaatac tctttcagaa gctgctgctg ttgattgcaa taaattggca
     1141 acctgtgcaa tctgagtcat tggctgtgta aagtttctta catattgtat aaatgactgt
     1201 atgtcaccaa cctcaattgt tttcttaatt gcaagccaac ctcctaagat tgataccatt
     1261 acatatccca agtttccaat aaacatcata agtggttgca ttatacctga taaaaattga
     1321 gatttccacg ctgaattata caggctatca tttagtttat caaactcttc aattacttca
     1381 tcctcacgat taaatgcttt tactattgtt tggccactgt aagtttcctc aacttgacca
     1441 tttacatttc ctaaatattc ttgttgatat ctaaagtatt tttgtgattt ctttattatt
     1501 cttgaaatta caaacattga tattggtaat attaaaactg ccactaatgt cataattcca
     1561 cttatagata acatcattat caaaacacct atcatagttg ttactgatgt tataagctgt
     1621 gtcatacttt gatttaaact ttgatttaaa gtatctatat cattcgtaat tctcgataat
     1681 atttcaccat gcgtcttagt atcaaaatac ttcattggca atctatccaa ttttgctgaa
     1741 atctcttttc ttaaattata ggatactttt tgagaaattc cactcattat aaatccttgt
     1801 ataaaagaga acagtgcact tatcaaataa aggaaaagta aaaaggttaa gatttttcca
     1861 attgcattaa aatctatacc tacgtttcct ccagaaactt tactcactag cccttcaaat
     1921 atctttgtag ttgcctttcc taaaattttt ggacctacta tagaaaacga cgcactacca
     1981 atagcaaata caattactag aattattgat attttaaatt tagataaata tgcaattagt
     2041 tttcgcatag tccctttaaa gtcatttgct ttttgtcctg ctcccataga ttttcccata
     2101 ggacctcttc ccattctact cattagctag ctcctccttt gaaagttgtg ataaagctat
     2161 ttgctcataa acttcgcaat tttttagaag ctctttatgt gttcctattc caactatttc
     2221 gccctcattt aaaacaatta tctgttctgc atttaagata gtactaattc tttgtgcaac
     2281 tattagaact gtactttcag cagtttttga ttttaaagcc ttacgaagag ctgcatcagt
     2341 ttttaagtca agtgctgaaa aactatcatc aaatatataa acttctggat tttttgctat
     2401 tgctcttgca atagaaagtc tttgtttttg acctccagat acatttgttc caccttgaga
     2461 aatttcagtt ttaaaagctt ccggtttaga atctataaat tctgtagctt gagctatttc
     2521 agctgctgtt ctcatttctt catctgttgc gtcttttcta ccatatttta agttggattc
     2581 tatagtacca gaaaacaata ctcccttttg aggtacatat ccaatttttt cccttaaatc
     2641 atgttgagaa acatttttta tattaactcc accaagtaat atttctcctt cagtaacatc
     2701 aaagaaacga ggaattaaat ttataagagt tgacttacca ctaccagtac ttcctataaa
     2761 ggcagttgtt tctcctggct ttgctgtaaa agatatattt gttaatatag gttcttctgc
     2821 gtctggatac atgaacgaaa catttttaaa ttcaacaaga ccctttttat cttccttaaa
     2881 ctcttgtgcc tctgattttt ctgggtcttt tatgcttata tctgacacta atacttcatc
     2941 tatacgtgta gctgaaacgg atgctcttgg aagcataata gataccattg atatcattaa
     3001 gaatgacatt attatttgca ttgtatattg tataaatgcc atcatatctc caacttgcat
     3061 tgctccagaa tcaacactgt atgcacctct ccaaactata agaactgtga taaggttcat
     3121 tataagcatc atagcaggca tcatacatgt cataactcta tttacaaaaa gatttgtttt
     3181 agttaaattt ttatttgctt tatcaaatct ttcttcttca tgtttttcag tactaaaagc
     3241 tctgataact ggaataccag taattatttc acggcttact aagtttaact tatcaacaag
     3301 cttttgaacc agtttaaact taggcataac cactgagaat aacactacaa ttaatgataa
     3361 gatagcaact actgctactg ctataatcca ggccattgaa gtatttgtgt ttaaaacctt
     3421 tatcactcca cctatagcca ttataggtgc atagaatact attctaagca acataaccat
     3481 caacatttgt atctgttgaa tatcatttgt actacgagta attaatgaag ctgtagaaaa
     3541 ttcattcatt tcagtatttg aaaatgacat aacttttcta aatactccac ttcttaaatt
     3601 tctacctaca cttgcggcta ctcttgctgc taaaaatcct actgttattg tagctaccat
     3661 actaatcatt gctataccaa gcattttagc accagtaaat aatatataat tattttgagt
     3721 tttttctgta tcaataccta ttttctcata ttctgacctt acatatgaaa cagagctttg
     3781 tgttatcata ctctctggca tactttcaaa gcctttgctc atctctttag tcaatgtatc
     3841 taactgttcc tttggcattg ctgataacaa tttaaatata tcaacatctc cactttgagt
     3901 agcttgtggt ggaagtttac tcattaactg agctttcata gcttttacct ctttactatc
     3961 gccctcaagc cctgatacta ttaaaatagc tttaccaaaa ataacattta aatcatctat
     4021 agtgtctttg tctttagtat ttaactcata aagagattca tcttttagac ctgggtactt
     4081 atctttatac ttaacataat cctttttatt cagcaaagta taattatcta gtactttatc
     4141 cttactactt ttatccataa ataaagtaat tttatttaat tcactctctc taatcacaga
     4201 tggaacagag ttttctactc caccttgttg tatacctaca tttactatat tggatgtgta
     4261 ttctggtaaa gaaaggtcac ataccgcttg aattaccaat agacagacta ttattactat
     4321 tgataatgcc gatttcttta aatatttaat taatttaaac atacatttct tcccttctgt
     4381 aatattaatt agtctaataa cattaaattg aaaaacatta ttttaaactt taaaaatatt
     4441 tttcatcttc atgcttatga catcctgctt ttaaattatc tcgtacttgc attagaagtc
     4501 ttctaagtac tattttttct tcttcactaa atcctaaaaa aaactctctt tccaattcct
     4561 tgttaaattc ttcaacttta ttacatattt ctaaaccttt gtctgtcaaa aaaatcctag
     4621 atactctttg gtccttttca tcttgttttc tttccacaag tccagctttt tccatcctct
     4681 ttatcataac tgtagttgta gatgctttta ctttcctttt atctgctaat tctttttgac
     4741 tttgcccatc tttcatcttt aaagaaaaaa gtatttgggg ttgaccatga tataagccta
     4801 atttatcaaa ataaaaatga gttcttataa aatatattcg cattaattgc aagaaaacat
     4861 catttaattt ttcttcagaa ttgctattca tacttgccct ccttattttt tatattactt
     4921 agtcggctaa gcattatttt actatactgc atgcattttt tcaatatatt tataaaaaat
     4981 tcatataaat ttcatttatt aaatattttt atatcatata gttataattt taataaataa
     5041 tagtaagatt tttaattagt cagctactta tattttttat tgtaaagctt aaaataaacc
     5101 ttttcatata ttttcaaata aaaaagttgt cccaaaataa attttgaaac aacatcttat
     5161 tcaacagtat cttgattata taacattatg atactctact tatcttcata tccatttaca
     5221 acaacatcta acttcccagt ttcaggtgat ataattagac catgtacaat aataccatct
     5281 ggaattaaag gatgcccttt tattaaatca atactatctt ttacagattc ttctgcagaa
     5341 tcgaatccat gtaaccattg ttttgtatca attccagcac tacgaagtgt aagtattaca
     5401 tcattagata ttcctctatc taaaatttta ccaagtaact tatccgtatc aacattacac
     5461 ataccacatc catgatgccc tacaaccata acctcatcta catcaaattc gtaaattgca
     5521 actaaaacac ttctcataat acttccaaaa ggatgcatta tagtagctcc tgcatttttt
     5581 attagtttca catctccatt tttcaaattc atagccttag gcaaaagctc agttaatctt
     5641 gtatccatac aagataagac tactattttt ttatttggat gttttgatgt cacatattgt
     5701 tcatattctt tgttctctac aaatgattta ttatattcta atatctcttc aagttttctc
     5761 atatgtaata tcaccctctt taaaaatttt tttattatta tatcactatt aaagtacaat
     5821 atatacacat ataatttaat ttatatttat taaattattt tataagatta ttactctact
     5881 ataaatcttg tatataactt gtatttataa gtatttgtat atttattttt tataatctaa
     5941 actaatatta tatattttca ttattttttt aattataatt tttttaaaat tttattctaa
     6001 atgccttact tataattaat tttttatttc acctatatat aattagattt aaaaatgttt
     6061 accttacc
//
LOCUS       DAEPID010000140         5823 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.142, whole genome shotgun sequence.
ACCESSION   DAEPID010000140 DAEPID010000000
VERSION     DAEPID010000140.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 5823)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5823)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5823
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.142"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            <1..172
                     /locus_tag="KR257_003644"
     CDS             <1..172
                     /locus_tag="KR257_003644"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018112794.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=2
                     /transl_table=11
                     /product="winged helix-turn-helix domain-containing
                     protein"
                     /protein_id="HBH0032300.1"
                     /translation="LLNVNITVTYLADMLGCKRETVSRMIKVLQKEELIKIDNKGFYV
                     KETELSRYFKNN"
     gene            complement(502..1692)
                     /locus_tag="KR257_003645"
     CDS             complement(502..1692)
                     /locus_tag="KR257_003645"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009271880.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="site-specific integrase"
                     /protein_id="HBH0032301.1"
                     /translation="MSNVKRKDSKNRNLRNGESQRKDGRYVYKYTDIYGKPQFIYAWK
                     LVPTDKTPAGKRDDISLREKEAQIKKDLDDGIDTAGGKMTVCQLYDKKNSQRKNIKRA
                     TEKGRQYLMNALKNDPLGMRAIDTVKQSDAKEWAIRMSERGYAYKTIDNYKRSLKASF
                     YMAIQDDCIRKNPFEFKLSDVLEDDTEPKVILTPEQEERLLAFMETDKIYSKYYDEVV
                     LLLETGLRISEFCGLTTHIDMQNRILNIDHQLLRDSEIGYYIDTPKTKNGKRKIPLTE
                     RAYQALQRILKNRVKAQPLVVGGYSNFLFLNREGLPKVAGNYVGMVRGLIKKYNKYHK
                     DKLPNITPHSFRHTYCTNMANKGMNPNTLQYLMGHANITMTLGYYAHGTFQSAKAELE
                     RLAC"
     gene            complement(1770..1973)
                     /locus_tag="KR257_003646"
     CDS             complement(1770..1973)
                     /locus_tag="KR257_003646"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002347229.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="excisionase"
                     /protein_id="HBH0032302.1"
                     /translation="MNNTDVPIWEKYTLTIEEASKYFRIGEKKLRKLAEENIDAGWVI
                     VNGNRIQIKRKQFEKIIDTLDEI"
     gene            complement(2355..2603)
                     /locus_tag="KR257_003647"
     CDS             complement(2355..2603)
                     /locus_tag="KR257_003647"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004613734.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="HBH0032303.1"
                     /translation="MKHTFKKPSYYLLSQAMDGDEKAIEKVLAFYDPYISKCCLRPLY
                     DEYGNVYIVVDMELKGLIREALIKMILGFDIALEIEEE"
     gene            complement(2607..3026)
                     /locus_tag="KR257_003648"
     CDS             complement(2607..3026)
                     /locus_tag="KR257_003648"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005361151.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sigma-70 family RNA polymerase sigma factor"
                     /protein_id="HBH0032304.1"
                     /translation="MKPSDFQKTVQCRFESCLKKVVRHVVKDYQQGLKRRKEKEISFC
                     ELPEIMVENLAVWDDYETDYTIFNVCGNDIRVYDDELAEALKQLSERNRETLLMYYFL
                     EMNNEEIAKKQNISRSGVFQNRHNSLALMRKLLKEKR"
     gene            3447..3806
                     /locus_tag="KR257_003649"
     CDS             3447..3806
                     /locus_tag="KR257_003649"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423065.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HBH0032305.1"
                     /translation="MRKTKETHTFDFRPLGLAIREAREKAGLSRNDLGDKVFYGERHI
                     ADIENIGSHPSFQLFHDLVTMFNISVDEYFYPAEKVAKSTARRQIETSLDLLSDNELK
                     IIQGTIDGILNSRENKK"
     gene            complement(3925..4110)
                     /locus_tag="KR257_003650"
     CDS             complement(3925..4110)
                     /locus_tag="KR257_003650"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011058338.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cysteine-rich KTR domain-containing protein"
                     /protein_id="HBH0032306.1"
                     /translation="MKDKWILCPVCGNKTRLKIRADTELKNFPLFCPKCKTETLINIK
                     HGKVTIIKEPDAKTQSR"
     gene            complement(4149..4436)
                     /locus_tag="KR257_003651"
     CDS             complement(4149..4436)
                     /locus_tag="KR257_003651"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015574378.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0032307.1"
                     /translation="MSTLIIGFIVAGVLLIAEYLLCTKFRSPLWGGIIPLLILAGTIY
                     VFASGRIPFERPYIFPFVVVNTLFFGDWGTGRDKYKKIKQTEMEKMKAKDI"
     gene            complement(4439..4735)
                     /locus_tag="KR257_003652"
     CDS             complement(4439..4735)
                     /locus_tag="KR257_003652"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009460866.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF2089 family protein"
                     /protein_id="HBH0032308.1"
                     /translation="MELDKIPQWILALEQEDATFLKNFALKSGSLKEIAKMYGVSYPT
                     VRLRLDKLIQKIEMCDQQEEEPFQTFIKGLAVDSRIDVETAKIIIEKYKKEKEK"
     gene            complement(4824..5729)
                     /locus_tag="KR257_003653"
     CDS             complement(4824..5729)
                     /locus_tag="KR257_003653"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002347248.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="conjugal transfer protein"
                     /protein_id="HBH0032309.1"
                     /translation="MFKKNKKQTENVKEKKVRTVKVGTHKKSVIALWVVLIASVSFGV
                     YKNFTAIDMHTVHETETIQLRLTDTNGIENFVKNFAKSYYTWNNSKEAIEARTQAISG
                     YLTKELQALNTDTIRKDIPVSSAVNGVQIWSVTQADENQFSVIFTVEQLITENGSTKT
                     VRSAYEVTVYVDGSGNMVLTKNPTITSIPVKSGYTPKAKESDGTVDAVTTDEINEFLT
                     TFFKLYPTATAKELSYYVNEGVLKPIGKDYVFSELVNPIYNRIDSQVTVSVAVKYLDQ
                     QTKATQVSQFDLVLEKSGSNWKIIK"
BASE COUNT         1611 a         1186 c         1026 g         2000 t
ORIGIN      
        1 tttactaaat gtaaatatta cagttacata tttagctgat atgcttggct gtaaaaggga
       61 gactgtttcc agaatgataa aggtattgca aaaagaagaa cttattaaaa ttgacaataa
      121 aggtttttat gttaaagaaa ctgaattatc aaggtatttt aaaaataatt aattatgatt
      181 aagtaagagt attattagaa ttttaattaa ataaaaatat tattaagaga atctatttat
      241 agattctttt ttattgtcta atttattaat ttttatttta ccctattgaa ttgtataaaa
      301 aaacaaataa gattcttttt tattcaaaaa acttactaaa tttttgatta tcttttcata
      361 agttggtaaa tgccgatata tcccgtattt gagggcttta tcggtatttt ctttttggaa
      421 gataccttgc ataagctggc atttaccagc atgaaaatgc aaccaaaagt agtaaatgag
      481 tagtaaatat acgttccgat attaacaagc cagtctttcc agttctgctt ttgcagattg
      541 gaatgtaccg tgtgcgtagt agccaagcgt catggttatg ttagcgtgtc ccatgagata
      601 ttgcagggtg ttcgggttca ttcccttgtt tgccatattc gtacaatagg tatgtcggaa
      661 tgaatgtggt gtaatgtttg gtaacttgtc tttgtggtat ttgttatact tcttaatcag
      721 tcctcgtacc atacccacat agtttccagc gactttaggc aatccctcac ggtttaagaa
      781 taggaaattg ctgtaaccac caacaaccag cggttgagct tttactctgt tctttagtat
      841 tctttggagt gcttgataag ccctttccgt caatggaatt tttcgttttc cgttctttgt
      901 ttttggagtg tcaatatagt agccgatttc gctatctctt aatagctggt ggtctatatt
      961 gagtattctg ttctgcatat caatatgcgt tgtcagtccg caaaattcag aaatacgaag
     1021 tcccgtttcc agaagaagca caacctcatc ataatacttg ctgtaaatct tatccgtttc
     1081 cataaaggca agcaggcgtt cttcctgctc tggcgtaaga ataactttcg gctcggtatc
     1141 atcttccaga acatcactta gcttaaattc aaacgggttc tttctgatac agtcgtcttg
     1201 tatcgccata taaaatgacg ctttcaagga acgcttatag ttgtcaatcg ttttgtaggc
     1261 atatcctctt tcactcattc tgatagccca ctctttagcg tccgactgtt tgacggtatc
     1321 aatcgctctc atacccaatg ggtcattttt cagagcgttc ataagatact gtcgtccttt
     1381 ttccgtagct cgcttgatgt tctttctttg gctgttcttc ttgtcgtaaa gctggcagac
     1441 tgtcatttta ccgcctgccg tgtcaatacc gtcatcaagg tcttttttta tctgtgcttc
     1501 tttttccctc aacgatatat catcacgttt tccagcaggc gttttgtctg tcggtacaag
     1561 tttccaagca taaataaact gtggctttcc gtatatatcg gtatatttat aaacgtatct
     1621 tccgtctttt cgctggctct ctccattacg caaattgcga tttttactgt cttttcgttt
     1681 cacattagac atagtgtaaa gctcctttcc gtcatggaat gagccgtgat acgctatact
     1741 tattatacca tatccacggc tctatgacat tagatttcgt ccaatgtatc tatgattttt
     1801 tcaaattgtt ttcgctttat ctgaatacgg ttgccgttca cgataaccca gccagcgtca
     1861 atattttctt cggctaattt acgcaacttc ttttctccaa tgcggaagta tttggacgct
     1921 tcttcaatcg tcagtgtata tttttcccag ataggcacat cagtattatt cataatttat
     1981 gcaccccctt tactgtgtgt cagtctataa gttatataaa caggcagacg gctttggaaa
     2041 gctccattag tatttcaact attcccattc ttgtgggcag aaccgcacca tgcggaagta
     2101 tcattatgct gtaagggtag gtcatggcaa aacgactttt ccaacggtcg ctctcggatc
     2161 actgcgtggg tcgctcgctt tcttttggaa aggtcatggc gtacagttcc cgtggctctc
     2221 tatccttaca aacgtatctg tctgctttat tcagttttca aagagctgtg gcgaaagcgg
     2281 tatgctttca tgtaaaagca ggagcagagc aggaaagagg ggattgaaca aatcatgctc
     2341 tgcgttactg ctggttattc ttcttcaatt tctaaggcaa tatcaaaccc taaaatcatt
     2401 ttgataagtg cttctcggat aagtcctttt aactccatat ctacaacgat ataaacatta
     2461 ccgtattcat catagagtgg acgcaaacag cacttcgata tgtaagggtc ataaaatgca
     2521 agtacctttt caatcgcttt ttcgtccccg tccatagctt gtgaaagcaa gtagtaagac
     2581 ggcttcttaa atgtgtgttt catttgctat cgtttctcct ttaatagttt tctcataagt
     2641 gccaatgaat tgtggcggtt ctgaaaaact ccgcttctgg aaatgttttg ctttttggcg
     2701 atttcttcat tgttcatttc caaaaagtaa tacatcaaca aagtttctcg gttacgttcg
     2761 gataactgtt tcaaggcttc tgccaattca tcatcataga cacgaatatc attaccgcat
     2821 acattgaaaa tcgtatagtc tgtttcgtag tcgtcccata cagccaagtt ttcaaccatg
     2881 atttctggaa gttcacaaaa ggaaatttct ttttcttttc ttcgcttcaa tccctgctga
     2941 tagtccttga caacatgacg gacaactttc ttcaaacagc tttcaaaacg gcattgaaca
     3001 gttttctgga agtcagacgg tttcatcaat ctcaccccct ttccgttatg acgtgaaaag
     3061 tgtttatccc tctttccgca ccatataggg aatggcaagt gtgatttgtt aagttgaaac
     3121 cagaaaaaat cgaaaaaact ttttagtaaa acaaaaacag cccgtgtgaa tgtgaataca
     3181 caaacggact gctttataaa tgctatctgt atgaattttt aactcttgta gagggtagaa
     3241 tgattgtaat actgaactaa aatatttttt cagttgggaa cagcaaagta ttattccata
     3301 tacaatcatg gcgtagcccc ctttaccaga gctatacctt gtgccaccaa tgaaaaagga
     3361 cggctctggc tatatccaaa accgccccgt tatgttttca agacgcacaa aagtatatca
     3421 tctcggaacg gttatggtga tttaaaatga gaaaaacaaa agaaacacat acttttgatt
     3481 tcagaccgct agggctggca atcagagaag cccgtgaaaa agctgggctt tctcgtaatg
     3541 atttaggcga taaggtattc tatggggaac gccatatcgc agatattgaa aatatcggtt
     3601 cacacccaag ttttcaatta ttccatgatt tagttaccat gttcaatata tcggttgatg
     3661 aatatttcta tccagcagag aaagttgcaa aaagcacagc tcgccgtcag atagaaacat
     3721 cacttgattt attgagtgat aacgaattaa aaattattca aggtacgatt gacggtatct
     3781 tgaacagcag ggagaataag aagtaatcag cttcttgttt tccccgtttt ctttttagcc
     3841 atatttcttc aagacttatt tgttgatctg ctttgcagga aacaaataag agccgacaat
     3901 ctataagtta caataaccta caaattatcg gctctgcgtc ttagcgtctg gctctttgat
     3961 aatagttact tttccatgct ttatattgat taaagtttcc gttttgcact tcggacaaaa
     4021 tagtgggaaa tttttaagct ctgtgtccgc tctaattttc aacctcgttt tattaccgca
     4081 aactggacat aaaatccatt tatctttcaa taatgcgttc ctcctatcta agtatacagt
     4141 tttgtaattt atatatcttt agctttcatc ttttccattt cagtttgctt tatcttttta
     4201 tatttatccc tgccagtacc ccaatctcca aaaaataaag tattgactac aacaaacggg
     4261 aaaatatatg gtctttcaaa tggtattctg ccacttgcaa aaacatatat tgttcctgcc
     4321 aagataagca agggaataat acctccccaa agaggacttc taaattttgt gcagagaaga
     4381 tactctgcaa ttaataaaac tcctgcaaca ataaagccaa taattaatgt actcatggtt
     4441 atttctcctt ttctttttta tatttttcaa taattatctt tgcagtttcc acgtcaattc
     4501 gagaatcaac cgctaaccct ttaataaaag tttggaaagg ttcttcttcc tgctggtcgc
     4561 acatttcaat tttttgaatt aatttgtcta aacgtaatcg aacagtaggg taagataccc
     4621 catacatttt cgctatttcc tttaatgaac cggatttaag tgcgaagttt ttaagaaaag
     4681 tagcgtcctc ttgctctaag gcaagaatcc attgagggat tttatcaagc tccaaaaaca
     4741 caactccttt catattatct ttaacaatat tcagtatatc ataaataaaa ttaaagtcaa
     4801 taagaattta aacatcaaaa taattatttt ataatcttcc agttgctccc gcttttttcc
     4861 agcaccaaat caaattgtga tacctgcgtt gcctttgtct gctggtcgag gtacttcaca
     4921 gccacggaaa ccgtcacttg actgtcgatg cggttgtaga tgggatttac cagttccgag
     4981 aatacataat ctttcccgat aggctttaac acgccctcat ttacataata ggacagctct
     5041 ttagcggttg cggttgggta gagcttaaag aacgtcgtca gaaattcgtt gatttcgtcc
     5101 gtcgtcacag cgtccaccgt tccgtcgctt tcctttgcct ttggcgtgta gccggatttc
     5161 acgggtatgc tggtaatggt cggattcttc gtgagaacca tgtttccaga gccatccaca
     5221 tagaccgtga cttcataggc ggagcgtacc gtcttcgtgc ttccattctc cgtgattaac
     5281 tgttccacag tgaagatcac ggagaactgg ttttcatccg cctgcgtgac agaccatatc
     5341 tgtaccccat tgaccgccga agacactgga atatccttgc ggatggtatc ggtattaagt
     5401 gcctgcaatt cctttgtcag ataaccgctg attgcctgcg tccttgcttc aatagcttct
     5461 ttgctgttat tccatgtgta ataggacttc gcaaagttct tcacgaaatt ttcaatcccg
     5521 ttggtatcgg taagtcttaa ctgtatggtt tctgtttcat gtacggtgtg catatcaata
     5581 gcggtaaaat tcttatatac cccaaaactc acgcttgcga taagcactac ccacaatgca
     5641 atcacagatt ttttatgtgt accgactttc acagtacgca ctttcttttc tttgacattc
     5701 tctgtctgtt tcttattctt cttaaacata ttttctaagt cctttctttt attttactcg
     5761 tcctgcaccg attaagtgtt gttgccagta actattattt aagtctgcat atcctatcgg
     5821 att
//
LOCUS       DAEPID010000141         5801 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.143, whole genome shotgun sequence.
ACCESSION   DAEPID010000141 DAEPID010000000
VERSION     DAEPID010000141.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 5801)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5801)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5801
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.143"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            150..491
                     /locus_tag="KR257_003654"
     CDS             150..491
                     /locus_tag="KR257_003654"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015994381.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptide chain release factor-like protein"
                     /protein_id="HBH0032310.1"
                     /translation="MANIYCENYNCKNYFEDMCMLERIEINNFKECESYLEGKNELYE
                     LENGYTIHPKDLKMVKSKDYSVEVTHIPTGITVKCRSTNSILKNKNKCLEVLEEELTK
                     INSHLELEDLR"
     gene            617..1024
                     /locus_tag="KR257_003655"
     CDS             617..1024
                     /locus_tag="KR257_003655"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009894734.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RusA family crossover junction
                     endodeoxyribonuclease"
                     /protein_id="HBH0032311.1"
                     /translation="MKVFLVIDGEPVGKERPRMNTYAKRTYTPNKTKNYEDLIKWLYQ
                     SKVKYYFEGYIKMTLRCYYSIAKSNSKKVKEQKRNNVLRPSKKPDIDNVIKVVADSLN
                     EIAYKDDTQIVEVVASKYYSDNPRVEVILEDVI"
     gene            1126..1974
                     /locus_tag="KR257_003656"
     CDS             1126..1974
                     /locus_tag="KR257_003656"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015994384.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ORF6C domain-containing protein"
                     /protein_id="HBH0032312.1"
                     /translation="MNENINKEITVLGTLEIEGMKFHNIEGGFGEHKKAMLVKDIAEI
                     HNRESRQINELINKNRKRFKDGKDILDLLGVGLDDTKIKELGFTQQSINSYRGLKNKG
                     LLSGIYILSERGYAKLLKILEDDIAWELYEKLVDGYFSMRKELNNPLLSASKELQAIF
                     MLDKKQEVLETKIENVNEKLENFMDDAPLFNIECESIVKEVKKVATKSLGGHGSKAYK
                     NKSLRGKVYNDIYHQIKREFGVDSYKAIKRCQLNKVLEIVNNYKLPIVFEEEIRLLNS
                     QLSIVS"
     gene            2077..2565
                     /locus_tag="KR257_003657"
     CDS             2077..2565
                     /locus_tag="KR257_003657"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009894737.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0032313.1"
                     /translation="MDNNINKKELFKKVEGRLHHYKFLSAEIKNLELDIESRENEIFG
                     CKAVGYDEKVSPTYAFNSTVENEIIKKERDITRLKKLKKDKEIEKKKIENALTCLDIR
                     EEHFFKLFYNSRMKNSMVYISLEMNSDRKTCRCVRERLVYKVMDMLYPRIKENELPLF
                     KN"
     gene            3312..3485
                     /locus_tag="KR257_003658"
     CDS             3312..3485
                     /locus_tag="KR257_003658"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009894739.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0032314.1"
                     /translation="MATKSILKNVDVRKKAFGRNLVSALENAKNKQEKEVVLSKKCSE
                     VPKDKIKDIFGRF"
     gene            3485..4096
                     /locus_tag="KR257_003659"
     CDS             3485..4096
                     /locus_tag="KR257_003659"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009894741.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="N-acetyltransferase"
                     /protein_id="HBH0032315.1"
                     /translation="MSGYLIVNLSNMLGELEEEEVKKILSSFSCPLNKDVEEFLKNKA
                     IEFSKQGLASTHLVLTSYKGKPVIVGYFTLANKYFTIKRKTLSNSLARKIVKFGQYNE
                     ELRRYIIGAPLIGQIGKNYSNNYNKLIKGDELLKIACDKIKAVQLDMGGKIVYLECED
                     KPKLIEFYKDNGFVDFGKRSLDKDETDSLDGDYLVQMLKYLKK"
     gene            4173..4361
                     /locus_tag="KR257_003660"
     CDS             4173..4361
                     /locus_tag="KR257_003660"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009894742.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0032316.1"
                     /translation="MEIKKNTQDVVSERKNSLDSEFKIPASGVCYMAEFIKESREIIK
                     ELDKHFESCLDVLSKARL"
     gene            complement(4341..4658)
                     /locus_tag="KR257_003661"
     CDS             complement(4341..4658)
                     /locus_tag="KR257_003661"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009894743.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0032317.1"
                     /translation="MSKNIDIRNLKQFQKKIERMEQNLKPDFDKIRTIILSKKFMNQH
                     TNFDSFDELLAFGNYIVNSEEDFLAIPDNEFDLFIVKNTDFPDWQTMLDSAYSKYLES
                     CLR"
     gene            4782..5009
                     /locus_tag="KR257_003662"
     CDS             4782..5009
                     /locus_tag="KR257_003662"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009894744.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0032318.1"
                     /translation="MGFEISGNLNFDSVIDDLKKEVENNPTIFTSQNVGNKFKEKCKI
                     CEKISEFEILEDGKVKCLECGTEFELNLKVE"
     gene            5079..5771
                     /locus_tag="KR257_003663"
     CDS             5079..5771
                     /locus_tag="KR257_003663"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861025.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="HBH0032319.1"
                     /translation="MQDVKEKVKQDYLKGMKQKEISSKYDISLNTLKSWIKRYNWASE
                     KKKGAPINKRGAPFSNKNSVGHGAPKENKNAEKFGFFSKYLPEETRELIQEISIKDKF
                     DILWEQITIQYAAIIRAQKIMYVKDKEEMIKELKKHESTENGEKIEYEFQFAWDRQAS
                     FLNAQSRAMSELRSLIKQYDEMIHKDWNLATEEQKTRVEKLKCEVDNLSKDDIGDDEL
                     KISVDYGDRNDS"
BASE COUNT         2414 a          588 c         1056 g         1743 t
ORIGIN      
        1 aggatgcaaa tacaaagaaa atatggataa agtatgtgaa gagaactata agaaattaag
       61 aagtaaatag aataaaatag tcaaggtaag tttgtgaatg aaactagaat gttatagact
      121 tactttgact tataaaagga gtgtgttaaa tggctaatat atattgtgaa aattataatt
      181 gtaaaaacta ctttgaagat atgtgtatgc ttgaaagaat tgaaattaat aacttcaaag
      241 aatgcgaaag ctatcttgaa ggtaaaaatg agctatatga attagaaaat ggatatacta
      301 tacatcctaa agatttgaaa atggtgaaaa gtaaagatta ttctgttgaa gttactcata
      361 ttccaactgg tattacagta aaatgccgtt ctacaaatag tattttaaaa aataaaaata
      421 agtgtttgga agttctagaa gaagaactaa caaaaataaa ctctcactta gagctagaag
      481 atttacgcta aataggaagt gagcttatga aacgaagaag atgcagttgg tgtggtaagt
      541 tattttatct tgaagaaaaa tctaaggatg tttattgttg taaagaatgt aggaagaagg
      601 ctaagaaggt gaaaaaatga aagtttttct tgtaatagat ggagagccag ttggcaagga
      661 aagaccaaga atgaatactt acgctaaaag gacctataca cctaataaga ctaagaatta
      721 tgaggaccta ataaaatggc tatatcaatc taaagttaaa tattactttg aaggttatat
      781 aaaaatgact ttaagatgtt attattctat agctaaaagt aacagtaaaa aggttaagga
      841 gcagaaaaga aataatgtgt taagacctag taaaaagcct gacattgata atgtcattaa
      901 agtagtagct gattcactca atgagatagc ttataaggat gatacacaga ttgttgaggt
      961 tgtagctagt aaatattata gcgataatcc cagggttgag gttatattag aagatgttat
     1021 ctaaccaacg gaaaaatccg ttcgttaaat tatgccctta gtttttcata aaaatgtgaa
     1081 aaagctaaat aaagaatata tcaaacgaca aaggagagat aaattatgaa tgaaaatata
     1141 aataaagaaa taacagtact tggaacttta gaaatcgagg gaatgaaatt tcataacatt
     1201 gagggtggat ttggagaaca taagaaagca atgctagtaa aagatatagc cgagatacat
     1261 aatagagaat ctagacagat taatgagctt ataaataaga atagaaaaag atttaaagat
     1321 ggaaaagata tattagattt gttaggtgtc ggtttggacg ataccaaaat aaaagaatta
     1381 ggatttactc aacaatcaat taattcttat agagggttaa aaaacaaagg gttattatct
     1441 gggatttata tattatctga aagaggttat gcaaaattat taaaaatatt agaagatgat
     1501 atagcttggg aattatatga gaagttagtt gatggatatt tctctatgag aaaagaacta
     1561 aataatcctc ttttaagtgc atcaaaggag ttacaggcta tatttatgct agataagaaa
     1621 caagaagtct tagaaactaa aatagagaat gttaatgaga aattagagaa ctttatggat
     1681 gatgcaccac tattcaatat tgaatgtgaa agtattgtaa aagaagttaa gaaggtagca
     1741 acaaaatcac taggaggtca tggaagtaag gcttataaaa ataaatcttt aagaggtaaa
     1801 gtatacaatg atatatacca tcagattaaa cgagagtttg gagtagatag ttataaggct
     1861 ataaagcgtt gtcaattaaa taaagtatta gagattgtaa acaattataa gttacctata
     1921 gtgtttgaag aagaaataag acttttaaat agtcaattat caatagtaag ttaaatttat
     1981 tcaaaaaaaa ggaaaaggag tgctttcaca ctccacttgt caaaaatata aaacttttat
     2041 ccaagattat tataacataa acaggagtgt ggaagtatgg ataataatat caataaaaaa
     2101 gaactattta aaaaagtaga aggtagatta catcattata aatttttaag tgcagaaatt
     2161 aagaatcttg aattagatat agaaagtaga gaaaatgaga tatttgggtg taaggctgtt
     2221 ggatatgatg aaaaagtaag tccaacatat gcttttaatt caactgttga gaatgagatt
     2281 ataaaaaaag aaagagatat tactagattg aaaaaactga aaaaagataa agaaatagaa
     2341 aagaagaaaa tagaaaatgc acttacatgc ttagatataa gagaagaaca tttttttaaa
     2401 ctgttttata atagtagaat gaaaaatagt atggtttata tatccttaga gatgaactca
     2461 gataggaaaa catgtagatg tgtaagggaa agattagtgt ataaagttat ggatatgctt
     2521 tatccaagaa ttaaggaaaa tgaactccca ttatttaaaa attagaaaat tccccagttt
     2581 ttccccagaa attcccactt tattccctac tttctcccct ttttgattaa aaaagcatga
     2641 gataatagta ttgtggaaat aaagatttcc ctctcaaaac ttaatatttg actagggtat
     2701 aagggattgc cctagtcact acgaacagac taggcagggc gtgaggacgc tgttagttca
     2761 attctaacta tgttcaaata ttaatcaacg tatacactaa aagtagagaa attgagggca
     2821 aaattttata ttttgtatct taattcagaa gtctaaaaat cgggtggggc ttggtaacct
     2881 cactcaccat gcaggtactg gtgtctagtc taagttcgat tcttagaacc tgcgacataa
     2941 tatatgtatc tccctactaa aaatgctaag tttactccaa acttagcatt ttaattttta
     3001 aaaagaaaaa agaaattttt attgtcataa tactatttgt ttaggtatat tataatgtgc
     3061 atacttaaaa ttaaatactt agcaagcatt tgaattaata tacataagat atatgacata
     3121 attttttata gtgtaagtta tttaaattaa ttataaataa cagtaatttt attatataaa
     3181 atgtacatat tgtgaataat aataataaaa tcatgtacaa aatgccaact gataattcct
     3241 cgaaatatat tgcatattta acgtaacgtc agtataatta aattataata gtgaagtgga
     3301 aggtggtact tatggctaca aaaagtattt taaaaaatgt agatgtaaga aaaaaggcat
     3361 ttggaagaaa tctagtatca gctctagaaa atgctaaaaa taaacaagaa aaagaagttg
     3421 tattaagtaa aaaatgttca gaagtaccaa aagataaaat aaaggatata ttcgggagat
     3481 tttaatgagt ggctatttaa ttgtaaactt aagtaatatg ctaggagagc tggaggaaga
     3541 agaagttaaa aaaattctct ccagtttttc ttgtcccctt aataaagatg tagaagaatt
     3601 tttaaaaaac aaagctattg aattttctaa acagggtttg gctagtacac atttagtgct
     3661 aacttcttat aaaggcaagc ctgttatagt tggatatttc actctagcta ataagtattt
     3721 tacaataaaa agaaaaacat tatcaaactc tttagctagg aaaatagtga agtttggaca
     3781 atacaatgaa gaactaagaa gatatattat tggagcacct ttgatagggc aaataggaaa
     3841 gaattattca aataattata ataaattaat caagggtgat gaacttctaa aaattgcatg
     3901 tgacaagata aaagcagtac agttagatat gggtgggaaa atagtgtacc ttgaatgtga
     3961 agataaacct aaattaattg aattttataa ggataatgga tttgtagact ttggaaaaag
     4021 aagccttgat aaagacgaaa cagattcgtt agatggggac tatttagttc aaatgttgaa
     4081 atatctaaaa aaataaaagt acataaaatc taaaatgact atcttgatag atggtctttt
     4141 tttatacaat aaattaaaag gagaatgaaa ttatggagat taagaaaaac acacaagatg
     4201 tagtatcaga aagaaaaaat tccctagatt ctgaattcaa gatacctgca agtggtgtgt
     4261 gttatatggc tgagtttata aaggaatcta gggaaatcat aaaagaatta gataaacatt
     4321 ttgaaagttg tctagatgtt ttatctaagg caagactcta aatattttga atatgctgaa
     4381 tcaagcatgg tttgccaatc tgggaaatca gtatttttaa ctataaataa atcaaattca
     4441 ttatcaggaa tagctaaaaa gtcttcttct gaattgacta tgtaattacc aaatgcaagt
     4501 agttcatcaa aagaatcaaa attagtgtgt tggttcataa atttcttgct aagaattatt
     4561 gtgcgaatct tatcaaagtc aggttttaaa ttttgttcca ttctttcaat tttcttttga
     4621 aattgcttta aatttctaat gtcaatattt ttactcataa gaacacctcc tttcaataga
     4681 atattagcat aaaattgtgg tgaattctgc tattgtcgaa cgattgttga aggatattgt
     4741 ataataacat agaatttact atactataag gaggtgatta tgtgggattt gagataagtg
     4801 gtaatttgaa ttttgacagt gttattgatg atttaaaaaa agaagttgaa aataacccta
     4861 ctatatttac atcacaaaat gttggaaata agttcaaaga aaaatgtaaa atatgcgaaa
     4921 aaatatctga atttgaaata ctagaagatg gtaaagttaa atgtttagaa tgtgggactg
     4981 aatttgaatt gaatcttaaa gtagagtaaa caaaaaaaga atctcaatta tgaggttctt
     5041 tttttattcc caaaacaaac aaataaagag gtggtgatgt gcaagatgtc aaagaaaagg
     5101 taaaacaaga ttacttaaaa ggaatgaaac aaaaggaaat atcatcaaag tatgacatta
     5161 gcttaaacac tttaaagtca tggataaaaa gatacaactg ggctagtgaa aaaaagaagg
     5221 gtgcacctat aaataaaaga ggtgcaccct tttctaataa aaattcagtt ggtcatggtg
     5281 ctccaaaaga gaataagaac gctgaaaagt ttggtttctt ctcaaaatat ctacccgaag
     5341 aaactaggga attgatacaa gaaatatcca taaaagataa atttgatatt ctttgggagc
     5401 agataacaat ccaatacgca gcaataataa gagcacaaaa gataatgtat gttaaagaca
     5461 aggaagaaat gattaaagaa ttaaagaaac atgaaagtac agaaaatgga gagaagatag
     5521 agtatgaatt tcaatttgca tgggataggc aagcatcttt tcttaatgca cagagtagag
     5581 ctatgagtga acttagaagt ttaattaaac agtatgatga aatgattcat aaggattgga
     5641 atttggctac agaggagcag aaaacaagag ttgagaagtt gaaatgtgaa gttgataacc
     5701 taagtaaaga tgatattgga gatgatgagt tgaaaataag tgtagattat ggtgatagaa
     5761 atgatagtta gagtaaattt taatccagat ttcaaggaag c
//
LOCUS       DAEPID010000142         5699 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.144, whole genome shotgun sequence.
ACCESSION   DAEPID010000142 DAEPID010000000
VERSION     DAEPID010000142.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 5699)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5699)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5699
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.144"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            complement(<1..183)
                     /locus_tag="KR257_003664"
     CDS             complement(<1..183)
                     /locus_tag="KR257_003664"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861569.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MBL fold metallo-hydrolase"
                     /protein_id="HBH0032320.1"
                     /translation="MRNKIFLSILIIISLLIGCDKKSLLSIHMIDVGQGDSILVQTPT
                     NKNILIDGGDEDSENII"
     gene            371..1276
                     /locus_tag="KR257_003665"
     CDS             371..1276
                     /locus_tag="KR257_003665"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454768.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF2156 domain-containing protein"
                     /protein_id="HBH0032321.1"
                     /translation="MFFKDIELNSKKELDPYFDLVDYEACEYCFSTLYMWQHVYKTGY
                     YIGEDFAVLVGEYEGDSFSILPLAKKDKLPEVVDFVLEYFSKNNKKIYLRGITTEVVE
                     FLKEKYPGRFEYIEERDLFDYIYDAESLRTLAGKKNQKKRNHINYFLKEYAGRYEAKL
                     LDKENFDECLVLMKEWESNKEENNEFDESMDDELIGIKKIFNHYDILKDKVKVFGVYV
                     DGKLEAFSIGELLNPNMALIHIEKANPDIRGLYPFINQQFLVSEFKDVEFVNREEDLG
                     IEGLRKAKLSYHPCRFVEKYSVREA"
     gene            1285..2469
                     /locus_tag="KR257_003666"
     CDS             1285..2469
                     /locus_tag="KR257_003666"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893611.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HBH0032322.1"
                     /translation="MEIRYAKEEEIESIKDIWSYCFNDTESFMKYYFNDKYKSENTVV
                     ALDEGKIISSLQLNQYKLLLNSKVYNTSYVVGVSTLPEGRGAGYMNKVMKFTLNELYK
                     KGQLVSILMPIDYRLYRRFGYEHCYDQIEYTINTDDLKNFKSSGKMIKSNLSQIDDLI
                     QIDRTFLNEVNGNVLKDEHYYENLFKEIQSEDGFLYIHEGNEKDGYIVYFLQEDKMFV
                     RELFYKNIDALKSMLKFIYNHNTQCKIVTISTPTIDKIRFILDNPKDSDIKIKPFMMG
                     RVINVKKFIEDIDIEKDINSSFNLLIEDKFIDENNGLFKISIQNKKVSVEQLDKKGAE
                     KPQEDFDIKLDINTLTQLSFSYIDVNEAIFLNDIKDVSEETLETLNCIFSKKNNYINE
                     YI"
     gene            2584..3885
                     /locus_tag="KR257_003667"
     CDS             2584..3885
                     /locus_tag="KR257_003667"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454765.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ComEC/Rec2 family competence protein"
                     /protein_id="HBH0032323.1"
                     /translation="MGVIIIQIRRPLLIILMFVVAISFIITNNTKNDEELNDKIITIQ
                     GVVKGKIEKKRYNQYKVGVFLINDYTKNKNLKIGQKVNITGKFKSLDKMKYDDFDYGR
                     YIKSTGYKGIVYINNYKIIDKNKLYSLIGEIKFYISKTYRYLYKKNSDFINSILLAEV
                     ENLTEEQKEIFTRTGTSHVISISGLHTGILCVIISFLLRGINKLYKLLILSIFITLYC
                     IMVGASPSIIRSIAFVMIFYLSIFIDRKKDGISALSLIGIILIMNNPYVIYNVSFQLS
                     FLATLSILIFYNKINSIIKLSMVSLTISSNILTLPIIYYTFKGIPLLSIIGNLIIVPF
                     VGVIMYLSIASLIVFKVSVVIAKIISFFNSTFIESIFFLLEKISNLSFAYINIENPKF
                     YIVVIYYIGVFFYIFYIEGKEIKEQENELQGYYKECKREKL"
     gene            3839..4882
                     /gene="holA"
                     /locus_tag="KR257_003668"
     CDS             3839..4882
                     /gene="holA"
                     /locus_tag="KR257_003668"
                     /EC_number="2.7.7.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416543.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA polymerase III subunit delta"
                     /protein_id="HBH0032324.1"
                     /translation="MNYKDIIRNVKEKNFEKMYLFYGREYYLIENAIKAFKDSLNEGM
                     LDFNLDIIDGKEIVLNQLISSIETLPFMDDRKIVIIKDFELLKGKKKNFTDSDEKYLI
                     EHLDNIPDTTTIVFVVYGDVDKRKSLVKKIGNNGIVFDCDKLSDMDLFKWIKKSFALN
                     DVIIDNSQIMYFIEQEGYRDKSSEKTLSDLENEINKISSFVGKGNNVTNDVIDKLSQK
                     KVENDIFKLIDYIGEQNASNAMKILNDMIQEGESVLGIFSMIARQFKIIMQVRQLQLD
                     GYSTKLIADKLKMHQFVVGKALKQTKNFSDDIIVEILNYILESDYKIKTGLIRDTLAV
                     EMLVSRYCKREAI"
     gene            complement(5069..5335)
                     /gene="rpsT"
                     /locus_tag="KR257_003669"
     CDS             complement(5069..5335)
                     /gene="rpsT"
                     /locus_tag="KR257_003669"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890686.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S20"
                     /protein_id="HBH0032325.1"
                     /translation="MANIKSAKKRISVIEKKTALNRVRKSQIKTAIRRFEDAVAAGNR
                     EDAVAKFQYAQKRIYQVASKGTIHKNAAARKVAKLAQKLNGMNA"
BASE COUNT         2288 a          515 c          867 g         2029 t
ORIGIN      
        1 aattatattt tcgctatctt catcacctcc atcaattaat atattcttat ttgtgggtgt
       61 ttgaactaaa atactatcac cttgtccaac atcaatcata tgtatagata gtagagattt
      121 tttgtcacag ccgattaaaa gtgatattat aataagtatt gataaaaaaa ttttatttct
      181 caataaaaaa tcactccatt cattacatgt ttatataaat ttatgatggg taatataaga
      241 tatatatgac ttattatatt ttatatttta aacaatataa atgaaattaa taccataata
      301 aaattggagt tttttatata tacaaaataa aatttttaaa attaagcaat aaaaaaggta
      361 ggaggatttt atgtttttca aagatattga actaaattca aaaaaagagt tagacccata
      421 ttttgattta gtagattatg aagcttgtga gtactgtttt agtactttat atatgtggca
      481 acatgtttat aagacaggat attatatagg tgaagatttt gccgttttag ttggggaata
      541 cgaaggagat agcttctcaa tattaccact tgctaaaaaa gataaacttc cagaagttgt
      601 agattttgtc cttgaatatt tttctaaaaa taataaaaaa atatacttaa gaggtattac
      661 tactgaagta gtagagtttt taaaagaaaa atatccaggt agatttgagt atatagaaga
      721 aagagattta tttgactata tttatgatgc agaaagttta agaactctag ctggtaaaaa
      781 gaatcaaaag aagagaaacc atataaacta tttcttaaaa gagtatgcag gtagatatga
      841 agctaaatta ttagataaag aaaactttga tgagtgttta gtactaatga aggaatggga
      901 aagtaataag gaagaaaata atgaatttga tgaaagtatg gatgatgaat taataggtat
      961 caaaaagata tttaaccatt atgacatatt aaaagataag gtaaaagtgt ttggtgttta
     1021 tgtagatgga aaattagaag cttttagtat aggagagctt ttaaatccaa atatggcatt
     1081 gattcatata gaaaaagcta atcccgatat aagaggtctg tatccattta taaatcaaca
     1141 atttttggta agtgaattta aggacgttga gtttgtaaat agagaagaag atttaggtat
     1201 tgaaggatta agaaaagcta aactttctta tcatccttgc agatttgttg aaaagtacag
     1261 tgttagggag gcttaataga ctatatggag attaggtatg ctaaagaaga agagatagaa
     1321 agtataaaag atatttggag ttattgtttt aacgatacgg agagttttat gaagtactat
     1381 tttaatgata aatataaatc tgaaaatact gtagtagctt tagatgaagg aaaaattatt
     1441 tcttctcttc agctaaatca gtataagtta ttactaaata gcaaggtata taatacatca
     1501 tatgtggtag gagtttctac acttccagag ggaagaggag ctggatatat gaacaaagta
     1561 atgaaattta ctttaaacga attgtataaa aaagggcaat tagtttctat attgatgcct
     1621 attgactata gactttatag aagatttgga tatgagcatt gttacgacca gattgaatat
     1681 actattaaca cagatgattt aaaaaatttt aagtcaagtg gaaaaatgat aaagtctaat
     1741 ttatcacaaa ttgatgattt gatacaaata gatagaactt ttttaaatga ggttaatggt
     1801 aatgtgttaa aagatgaaca ttattatgaa aacttattta aagagattca aagtgaagat
     1861 ggatttttat acattcatga aggaaatgaa aaagatggat atatagttta ttttcttcag
     1921 gaagataaaa tgtttgtcag agagttattt tataaaaata tagatgccct taaatcaatg
     1981 cttaaattta tatataatca caatactcaa tgtaagatag ttactatatc tactcctaca
     2041 atagataaga taaggtttat attagacaac cctaaagata gtgatataaa aataaaacct
     2101 tttatgatgg gaagagttat aaatgtaaag aagtttattg aagatataga tattgagaag
     2161 gatattaata gctcatttaa tttattaata gaagacaagt ttatagatga aaataatggt
     2221 ctatttaaaa tttctataca gaataagaag gtatctgtag agcagttaga taaaaaaggt
     2281 gcagaaaagc ctcaagaaga ttttgatatt aaattagata taaatacctt aacacagtta
     2341 tcattttctt atatagatgt aaatgaagct attttcttaa atgatataaa agatgtttca
     2401 gaagaaacac tagaaacact taattgtatt ttttctaaaa aaaataacta tataaatgaa
     2461 tatatatagg tagagtacgt taaaagattc taaaaatctt ttgacgtatt tttttgttta
     2521 gataacaatt tatcttgttt aaaaattttc tatttgaaaa taatctaaat aatatacttt
     2581 tatatgggag tgattataat tcaaataaga agaccattat taattatatt aatgtttgtg
     2641 gtagctatat catttatcat tacaaataac acaaaaaacg acgaagaact taatgataag
     2701 ataataacta tacaaggagt tgtcaaagga aaaattgaaa agaaaagata caatcagtac
     2761 aaggtagggg tttttctaat aaatgattat acaaaaaata aaaatttgaa gattggtcag
     2821 aaagttaata ttacaggtaa attcaaaagt ttagataaaa tgaagtatga tgattttgat
     2881 tatggaaggt atataaaaag tactggatat aaaggtatag tgtatataaa taactataaa
     2941 attattgata aaaataaact ttactcttta ataggggaaa taaagtttta tattagtaaa
     3001 acttataggt acttatataa gaaaaactca gattttataa attctatact attagcagaa
     3061 gttgaaaatt tgactgagga acaaaaagaa atttttacca gaactggaac tagtcatgta
     3121 atatctatat caggtcttca tacaggaata ttatgtgtaa ttatatcctt tctattaaga
     3181 ggtataaata aattgtataa attattaata ctgtcgattt ttataacttt atattgtata
     3241 atggtaggtg cgtctccatc cataattagg tctatagcat ttgttatgat tttttattta
     3301 tcaatattta ttgatagaaa gaaagatgga atatcggcat tgtctctaat tgggataatt
     3361 ttaattatga ataaccccta tgttatatat aatgtaagtt ttcaattgtc ttttttagct
     3421 acactttcta tattaatatt ctataataaa ataaatagta ttataaaatt aagtatggta
     3481 tcattgacaa tatcatcaaa tatattaact ttacctataa tttattatac atttaaaggt
     3541 ataccattgc tttcaattat aggaaattta attatagtgc catttgtggg agtaataatg
     3601 tatttaagta ttgcaagttt aatcgtattt aaagtaagtg tagtaatagc taaaattata
     3661 tcttttttta atagtacatt tatagaaagc atattttttt tactagaaaa aatcagcaat
     3721 ttaagttttg catacattaa tatagaaaat cctaaatttt atattgttgt tatttattac
     3781 ataggagtgt ttttttacat attttacata gaaggaaaag agataaagga gcaagagaat
     3841 gaattacaag gatattataa ggaatgtaaa agagaaaaac tttgaaaaaa tgtatctttt
     3901 ttatggaaga gagtattatt taattgagaa tgcaataaaa gcatttaaag atagtctaaa
     3961 cgagggaatg cttgatttta atttagatat aatagatggg aaggaaatag tcttaaatca
     4021 gcttataagc tctatagaaa cacttccatt tatggatgat aggaagatag taataataaa
     4081 agactttgaa ctattaaaag gaaagaaaaa gaattttaca gatagtgatg agaaatactt
     4141 aatagagcat ttagacaata ttccagacac cacaactata gtttttgttg tatatggaga
     4201 tgtagacaaa agaaaatcat tagttaagaa aataggaaac aatggaattg tttttgattg
     4261 tgataagctt tctgatatgg atttgtttaa atggataaaa aaatcttttg ctttaaatga
     4321 tgttataata gataattctc aaatcatgta ttttattgaa caagaaggat acagagataa
     4381 gagtagtgaa aagacattat ctgatttaga aaatgaaata aataaaataa gttcatttgt
     4441 tggtaaaggg aataatgtaa ccaatgatgt aattgataaa ttatctcaaa aaaaagttga
     4501 gaatgatata ttcaaattaa tcgattatat tggagaacaa aatgcttcta atgcaatgaa
     4561 aatattaaat gatatgatac aagaaggcga atctgtatta ggtatatttt ctatgatagc
     4621 aagacaattt aaaataatta tgcaagtaag acagttacaa cttgatggat attcaacaaa
     4681 acttatagct gataaattaa aaatgcatca atttgttgta ggaaaagcat taaagcaaac
     4741 taaaaatttt tctgatgata taattgtgga aatattaaac tatatattag aaagtgatta
     4801 caaaataaag acaggtctta taagagatac tttagcagtt gaaatgttgg ttagtagata
     4861 ctgtaaaaga gaagcaattt aaaaaatcta tatattaata aaaaataaat agcaagatat
     4921 gttatagttc agagtagatg taagctaaat taagtttgat atacaatcaa ctataatatg
     4981 tctaactatt tattttttat tgtataaatt tacaaaataa aaaaccccta cataggggtt
     5041 attatatata agaaatataa actggtaatt aagcgttcat accgtttaat ttttgagcta
     5101 atttagctac ttttctagct gcagcattct tatgtatagt tcctttagaa gctacttggt
     5161 atattctttt ttgagcgtat tggaacttag caacagcatc ctctctgttt ccagctgcaa
     5221 cagcatcttc gaatcttctt attgcagttt ttatttgaga ttttctaact ctatttaaag
     5281 cagttttctt ttcgataaca cttattcttt tcttagctga ttttatattt gccaccgtgt
     5341 tcacctccct gtattttttt atcatattca tcgtcaacat attagatttt aacagaaata
     5401 aatctaaaaa tcaaggatta ttatttatat attttaataa tgttttttat tttgattttt
     5461 tagactgtaa attgtgtata aataatttgc aatatcttgt ttttaaattg gtatattttg
     5521 tgttttaaat attttgacat atataattaa tatttcattt tgtaacaaat atttgagata
     5581 atacaaacta ttaacataca ttttgatagt atttccaata attataagat aatacaagaa
     5641 attactcatt tttgtaaatt taatgaaaaa ttataaaaat ataaatttat atgcttaat
//
LOCUS       DAEPID010000143         5620 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.145, whole genome shotgun sequence.
ACCESSION   DAEPID010000143 DAEPID010000000
VERSION     DAEPID010000143.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 5620)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5620)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5620
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.145"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            complement(28..765)
                     /locus_tag="KR257_003670"
     CDS             complement(28..765)
                     /locus_tag="KR257_003670"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434827.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HBH0032326.1"
                     /translation="MIKVLICDDDKIVRDDIANIAKESGYVDYVKKVKDGIEAIEFIK
                     NEKIDLLIIDIDMPYKNGIDSAEEILSIDKDIHIVFVTGFADYSLESFKVHPIDFVVK
                     PFKKEKILDSINIAIDHINSHKIANNNFIEDTLFVYKIRKQIHMINFDDIVMFEKNSR
                     AINLHTKDEDIIKFYENFDDLKKRLPPNFFMTHRQYIVNLRFIHKVIPINKSSLEIRF
                     INFQENAILNKSLEKDFLYRFYRVKRF"
     gene            complement(784..1719)
                     /locus_tag="KR257_003671"
     CDS             complement(784..1719)
                     /locus_tag="KR257_003671"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434825.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GHKL domain-containing protein"
                     /protein_id="HBH0032327.1"
                     /translation="MANNFVFPIVILTLFIFSNLIMNKYKFYKELDILKRGILTFFIS
                     CFALILFMEGTKYIQLRLGYSFLLEGVLNIILFLVLIILSFYTGFKVIRLINNNNEQE
                     YKLQKLDSKINHKDNIIIKLRSQKHDYLKHLQVVYSLLNTGLDEDAKEYIMNISNSFK
                     SKNSRYGKVSYLDAIASLKYEECLEKDISFDVYIQDFMDNLEIEPNDMSSVLLNIIDN
                     AIESLSTIKKEKKYIRVHAYEDEFQYIIAIKNNGPKIHNVESIFWNGFSTKEGQDRGY
                     GLHLVKNILDKYDYSILVNSDDFLTEFVILIPKYY"
     gene            1927..4503
                     /locus_tag="KR257_003672"
     CDS             1927..4503
                     /locus_tag="KR257_003672"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434823.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="FtsX-like permease family protein"
                     /protein_id="HBH0032328.1"
                     /translation="MKDNLKIVLRYIKSYKARSLAIVVSIILATSLVVGIGTLSRSAQ
                     QADVDRLKRELGTDHVYFKNIKKNQLKSIKSSKDIKNLGITSYYASTDVNEKLPINIL
                     YANKNYLTSHSKLIKGRFPKASNEVVVEKWILNSMGLKPEINQNLTFKLYQKENPETF
                     KVVGILEDRFIEKKKGQCEIFSNLNESELNDFTTYIEFNEGSDINTNIDNIIKNAMLD
                     EKSIGRNSMLIESTMKNGTLDNSSKYVAIAMSLFAGIVIYSIYVISIYQRVQEYGVLR
                     AIGSTNFRIFKLMLYELFILALIAMPIGICIGMGGAQIFNRSVGNIQFEGNINVTPFV
                     IPDKIILLSIACTILIILIISFFTYLKIRRISPIDAIRKTFGADKNVTKVNYLISKLT
                     LNMSVTKSISAKNIFRNKKGFIIIVLSMSIGGIIVIKDNYKYSFLDVQNKSTQEQTYM
                     NADFILSNVYLNEIGNNTSFKDIKGFNDNQIDKIKNIDGIDKVKTASILNTRIEVNKI
                     NRLDYYEAINSTPYYKLNPLFIKNKTTGKYTLKQKLKGYNDEMIKSLEKYLVSGNINL
                     KKMKKENLAIVYVPEISKTQKYTKTFTPGEGTPAVDIKVGDTIKVKYPKGGMDTGLYE
                     SLKDNYEYLEYEFKVGAIISYPFADNGMYSGDDGVDVITSSEYLKKLTGVDKYNLVYA
                     DLNENANKKKINNLLGKIGSEVPGTTTVDMMVEKENSDKMTSRTMIYSYGIVAIMFII
                     SVLNIINNISYNLTSRTSEFGMLRAIGISERGFKNMILYEGILYGVLSSIITIVSGII
                     IQFKMYYMQGFVSYGLGFSIDYKIYILVILANIIVGILATYIPSRKINKISIVEAINI
                     TE"
     gene            4515..5186
                     /locus_tag="KR257_003673"
     CDS             4515..5186
                     /locus_tag="KR257_003673"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895404.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBH0032329.1"
                     /translation="MPILETINLGKIYGKKETSVHALKNANLKINKGEFVAIIGPSGS
                     GKSTFLHLVGGLERPSNGTIKVDGKDICCLSDKELARYRRQKVGFVFQQYNLIPVLNV
                     KENIELPLKLDNKKIDKEYIDDLINLLGLNERKNHLPNQLSGGQQQRVAIARALSAKP
                     SIILADEPTGNLDSKTTEEVMDLLKSSIKKYNQTLIIITHNENIARKADRIISIIDGE
                     LKLTL"
     gene            5213..5554
                     /locus_tag="KR257_003674"
     CDS             5213..5554
                     /locus_tag="KR257_003674"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434819.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0032330.1"
                     /translation="MLLILGNLNLNLDFDYRIIREENDDVDIFIDINYRSLDIDTDGS
                     NLFNSRIQFPFVRALILRLNKNNQCMTIHLLRDIDLFSAFANFEVDYTDSIINIKNQN
                     EKVILNKSIKK"
BASE COUNT         2214 a          704 c          761 g         1941 t
ORIGIN      
        1 acaaaaagta tttttcttct atcttcacta gaatctttta accctataaa atctatataa
       61 aaaatctttt tctagagatt tgtttaatat ggcattttct tgaaaattta taaaccttat
      121 ctctaatgaa gatttattta taggtataac cttatgtata aatcttagat ttactatgta
      181 ttgtctatgg gtcataaaga aattaggagg taggcgtttt tttaaatcat caaagttctc
      241 ataaaacttt attatatctt catctttagt gtgtagatta attgctcttg aatttttctc
      301 aaacataact atatcatcaa aattaatcat atgtatctgc ttccttattt tatatacaaa
      361 aagggtgtct tctataaaat tattattagc aatcttatgg gagttaatat ggtctattgc
      421 tatgttaatt gaatcaagta ttttttcttt tttaaatggt ttaactacaa aatctatagg
      481 atgcacttta aagctttcaa gactataatc agcgaaaccc gtcacaaata ctatatgtat
      541 atccttatct atagaaagaa tttcttcagc agaatcaatc ccatttttat atggcatatc
      601 aatgtcaata atcaataaat ctattttctc attttttata aattcaattg cctctatacc
      661 atccttaact tttttaacat aatctacata tccagactct ttagctatat ttgctatatc
      721 atctcttaca atcttatcat catcacaaat caaaactttt atcatagact tttctcctcc
      781 taactaataa tattttggga ttaagattac aaattcagtt aaaaaatcat cactatttac
      841 aagtatacta taatcatact tatctaatat atttttaact aaatgtagcc catatcccct
      901 atcttgtcct tctttagtac taaatccatt ccaaaatata ctttcaacat tatgtatttt
      961 aggaccatta ttttttatag ctataatata ctgaaattca tcttcatatg catgtactct
     1021 tatatacttc ttttcttttt ttatagtaga caaagactct attgcattat ctattatgtt
     1081 taatagtact gaactcatat cattaggttc aatctctaaa ttatccataa aatcttgaat
     1141 gtagacatca aaagatatat ccttttcaag acattcctcg tattttaatg aagctatagc
     1201 atctaaataa gatacttttc cataccttga attttttgat ttaaaactat ttgatatatt
     1261 cattatatat tctttggcat cttcatctag cccagtattt aatagagaat acaccacttg
     1321 caaatgtttc aaatagtcat gtttttgact tcttaatttg ataattatat tatccttatg
     1381 atttatttta ctatctagtt tttgtagttt atattcctgt tcattattat tatttatcaa
     1441 tcttataact ttaaagcctg tataaaaact taaaataatt aaaaccaaaa aaagtataat
     1501 atttaatact ccttcaagta aaaaactata tcctaacctt aattgtatat atttagtgcc
     1561 ctccataaat aaaatcaatg caaaacacga tataaaaaat gttaatatgc ctctttttaa
     1621 tatgtctaat tctttgtaaa atttatactt attcattata agattgctaa atataaacaa
     1681 agttagtatt actataggaa atacaaaatt gttagccatg atttccctcc cctctacaat
     1741 ttatataggg attatatcat tttaaaaaaa ttatgtaaaa agttaaaatt tacatataga
     1801 ttaattaaac ttgtaaaaat acagatgaat ttgtacaatt aactacttaa aacttgaaaa
     1861 tacttacttt gctatatatt ttagataaat atataattga tttagttaag aaaggaagtg
     1921 gtaaatatga aagataattt gaaaatagta ctaaggtata taaaaagtta taaagctagg
     1981 tctttagcaa ttgttgtgag tataattctt gctacatcac tcgttgttgg tattggtacc
     2041 ctctcaagaa gtgctcagca agcagatgta gatagattga aaagagagct tggaactgac
     2101 catgtatact ttaaaaatat aaagaaaaat caattaaagt ccataaaatc tagcaaagat
     2161 attaaaaatc tgggtataac atcttactat gcgtctacag atgttaatga aaaattacct
     2221 ataaacatac tatatgcaaa taaaaattat ttgactagtc attctaaact tataaaaggt
     2281 cgatttccaa aagctagcaa tgaggtggta gtcgagaaat ggattttaaa tagtatgggc
     2341 ttaaaaccag agataaatca aaaccttact tttaaattat atcaaaaaga aaatccagaa
     2401 acttttaaag ttgttggaat ccttgaagat agatttatag agaaaaaaaa gggacaatgt
     2461 gaaatttttt ctaatctcaa tgaatcagaa ctgaatgatt ttacaactta tattgaattt
     2521 aatgaaggca gtgatataaa tacaaacata gacaatataa taaaaaatgc tatgttagat
     2581 gagaaaagta taggaagaaa ctcaatgctt atagaatcta ctatgaaaaa cggtacttta
     2641 gataattcaa gtaaatacgt tgcaattgct atgagtctat ttgctggtat tgtaatatat
     2701 agtatctatg ttatatcaat ataccaaaga gtacaggaat atggcgtctt aagagctatt
     2761 ggttccacca actttaggat tttcaaactt atgctttatg aacttttcat acttgctcta
     2821 atagcaatgc ctataggtat atgtataggt atgggaggtg cacaaatatt taataggtct
     2881 gtaggaaata ttcaatttga aggaaatata aatgttacac cttttgttat tccagataaa
     2941 ataattctct tatcaattgc atgtacaata ctaataatac taattataag tttctttaca
     3001 tacttaaaaa taagaagaat ttctcctatt gatgctatca gaaaaacttt tggagctgat
     3061 aaaaatgtaa ccaaagttaa ttatttaata tcaaaattaa ctttaaatat gtcagtaaca
     3121 aaatctatat ctgcgaaaaa catctttaga aataaaaagg ggttcattat aattgtatta
     3181 tctatgagta taggaggtat aatcgtcata aaagacaatt ataaatattc ttttttagat
     3241 gtgcaaaaca aatctactca agaacaaaca tatatgaatg cagattttat tctatcaaat
     3301 gtttatctca atgaaattgg taacaatact tcttttaaag atataaaagg gtttaatgat
     3361 aatcagatag ataaaataaa aaatatagat ggaattgaca aagtcaaaac tgctagtatc
     3421 ttaaacacaa gaatagaggt aaataaaata aatagattag attactacga agctataaat
     3481 tcaactcctt attataagct aaatcctctg ttcataaaaa ataagactac tggcaaatat
     3541 acactaaagc aaaagctaaa aggttataat gatgagatga taaagtcatt agaaaaatac
     3601 ttagtaagtg gaaatataaa cttgaaaaaa atgaaaaaag aaaatttagc tattgtatat
     3661 gtaccagaaa tttctaaaac acagaaatac acaaagactt ttactcctgg tgaaggaaca
     3721 ccagctgtag atataaaagt aggtgatact ataaaagtca aatatccaaa gggtgggatg
     3781 gatacagggc tttatgaaag tctaaaagat aattatgaat acttagaata tgaatttaaa
     3841 gttggagcta ttataagtta tccttttgca gataatggta tgtactctgg agatgatggt
     3901 gtagatgtaa taacgagtag cgaataccta aaaaaattaa ctggtgtaga taagtataac
     3961 ttagtttatg cagaccttaa tgaaaatgca aacaagaaaa aaataaataa ccttttaggt
     4021 aaaattggaa gtgaagttcc tggaactaca acagtagata tgatggtaga aaaagaaaat
     4081 tctgataaga tgacatctag aactatgatt tatagttatg gtatagtagc aataatgttc
     4141 ataatcagtg tacttaacat aataaacaac ataagttata acttaacttc aagaactagt
     4201 gaatttggaa tgttaagagc tattggtatc tctgagagag gctttaaaaa tatgatactt
     4261 tatgaaggaa tattatatgg tgtactctca agtataatta ctatcgtgtc aggaattata
     4321 atacaattta aaatgtatta tatgcagggc tttgtatcat atggattggg attttcaata
     4381 gattacaaaa tatatatcct agttatttta gcaaatataa ttgttggtat tctagctaca
     4441 tatattccat caagaaagat aaataaaatt agtatagttg aagctataaa cattacagaa
     4501 taggagggat aattatgcct atattggaaa ctattaattt aggtaagatt tatgggaaaa
     4561 aggaaacatc tgtacatgca ctaaagaatg caaatttaaa aataaataaa ggcgaatttg
     4621 ttgctataat tggaccaagt ggaagtggga aaagtacatt tctacattta gtaggtggtc
     4681 ttgaaagacc aagtaatggt actataaagg tagatggtaa agatatatgt tgtctttcag
     4741 ataaagaatt agcaagatat agaagacaaa aggtaggatt tgtctttcaa cagtataact
     4801 taattcctgt attaaatgta aaggaaaata tagaattacc actaaagtta gacaataaaa
     4861 aaatagataa agaatatatt gatgacctta taaatttatt gggtcttaat gaaaggaaaa
     4921 atcatcttcc caaccaatta tctggtggtc aacagcaaag agttgctatt gcacgtgctt
     4981 tatctgcaaa accaagtata atcctagcag atgaaccaac aggaaatttg gacagtaaaa
     5041 ctacagaaga agtcatggat ttactaaaaa gttctataaa aaaatataac caaaccctta
     5101 taataataac acataatgaa aatattgcta gaaaagcaga tagaattata tctataatag
     5161 atggagagct taaattaaca ctctaaaact atttatagaa aagaggattt aaatgttatt
     5221 gattttaggt aatttaaatt taaacttgga ttttgactac agaataataa gagaagaaaa
     5281 tgatgatgta gatatattta tagatattaa ttatcgtagc ttagatatag atactgatgg
     5341 ttctaactta tttaattcta gaatacaatt tccatttgta agagcattga ttctaaggct
     5401 aaataagaac aatcaatgta tgacaattca tttgttaaga gatatagatt tattctctgc
     5461 ttttgccaac tttgaagtgg attatactga ctctataata aatataaaaa atcaaaatga
     5521 gaaagtaatt ttaaataaat ctatcaaaaa atagtaaggg ggccttaata ggccccaatt
     5581 tttttctttt ctaaacttat tatatcatga taaataaatt
//
LOCUS       DAEPID010000144         5525 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.146, whole genome shotgun sequence.
ACCESSION   DAEPID010000144 DAEPID010000000
VERSION     DAEPID010000144.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 5525)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5525)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5525
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.146"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            50..166
                     /gene="rrf"
                     /locus_tag="KR257_003675"
     rRNA            50..166
                     /gene="rrf"
                     /locus_tag="KR257_003675"
                     /product="5S ribosomal RNA"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00001"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: cmsearch."
                     /db_xref="RFAM:RF00001"
     gene            complement(380..1564)
                     /locus_tag="KR257_003676"
     CDS             complement(380..1564)
                     /locus_tag="KR257_003676"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436323.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pyridoxal phosphate-dependent aminotransferase"
                     /protein_id="HBH0032331.1"
                     /translation="MLSKRLNFITPSYTIGISSKVKEMESNGVKVINLSIGEPDFNVP
                     NNAKSYGIDSLNKDYTKYDLVPGLKILREEICKKLIEENNCNYSIDEIVVSSGAKNSI
                     TNTLLALTDEGDEVLLPKPYWVSYPEMIKLVNAVPVFIDTKKENGFKLTKEELEKSIT
                     DKTKILVINNPSNPTGSVYTKDELIEIVDVCIQNKIYILADEIYEKICYTGEFTSIAS
                     LSEEAKDITITINGFSKSAAMTGLRLGYTASNKTIAKAMSSIQGHLISHPSLTAQYIA
                     YGALKDCSIDIDNMVKTYKSRRDLIKSKLDSIDNVGYVNPNGAFYIFIDLSKVSEKFE
                     YKDSFSIEFCNQFLEEYNVAVVPGIAFGMDKYIRISYACSENTFLSGLDKLKEFVYKI
                     MA"
     gene            1937..4288
                     /locus_tag="KR257_003677"
     CDS             1937..4288
                     /locus_tag="KR257_003677"
                     /EC_number="1.17.4.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728903.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="anaerobic ribonucleoside triphosphate reductase"
                     /protein_id="HBH0032332.1"
                     /translation="MVEFVKKRDGRVIPFNEDRITRAIFLAATNVAEREGIVPDYKLS
                     EQLTQEVIKFLNHKYSESVPSVEDIQDSVVKVLIETGHAKTSEEYIIYRTERSRIRNS
                     KTRLMKAIEEITFEDAEDADIKRENANINGNTAMGTMLQYGSTVSKEFCKTHILKPEH
                     SFAHDNGDIHIHDMDFLNMGTLTCCQIDVKKLFNGGFSTGHGFLREPQDIISYGALAA
                     IAIQSNQNDQHGGQSIPFFDYGLAEGVYKTFKKFYIGNLAKALKLFKGIENNDVIKNI
                     VYNTEKETNQKVGLKRDELYLNLEKEKLIQTFDIDDELVNKMQNFAFEESYRETDKKT
                     YQSMEAFIHNLNTMHSRAGAQVPFSSVNFGTDTSEEGRMVTKNLLLSQERGLGNGETP
                     IFPILIFKVKEGINLNPEDPNYDLFKLSCRVSAKRLFPNFSFLDAPFNAKYYKKGEPD
                     TEATYMGCRTRVLSNVCGSETVSGRGNISFTTVNLPRLGIKHGIINNEKANLDGFFEE
                     LDEKINLIIEQLLERLEVQGNKKMKNFPFLMGQGVWKGSDDLGPEDTLKEVIKQGTLT
                     IGFIGLAECLIALIGKHHGESKEAQELGLKIVSHMRHKMDEATDKYKLNFSLMGTPAE
                     GLSGRFTKIDKKVYGEIKGITDKEYYTNSFHVPVYYNISAYDKIEIEAPYHELTNAGH
                     ITYVELDGDPSDNLEAFETVIKAMKDLGIGYGSINHPVDRDPICGFSGVITSNICPVC
                     GRNEDESDIKFERIRRITGYLVGTVDRFNNAKKAEVRDRVKHR"
     gene            4310..4849
                     /gene="nrdG"
                     /locus_tag="KR257_003678"
     CDS             4310..4849
                     /gene="nrdG"
                     /locus_tag="KR257_003678"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003432598.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="anaerobic ribonucleoside-triphosphate reductase
                     activating protein"
                     /protein_id="HBH0032333.1"
                     /translation="MKIRMSSTISYDSIVDGPGLRMVIWTQGCIHNCKECHNPQTHDL
                     CGGFYMDTEEIINKVKSLKLQKGITLSGGEPFLQPEPLEEIAKEAKINGLDVWSYTGF
                     TFEQLLDKKNRAYFKNLNLLKQIDILVDGKFIAEKKDISLKFRGSSNQRIIDVQKSLK
                     YKQVFLVEQYMKDDLSIAE"
BASE COUNT         2151 a          625 c          888 g         1861 t
ORIGIN      
        1 ttctataaac ttattaaaaa cttaatagaa atattaagca taaagattat gtggttacaa
       61 tagcagagag gatacacctg ttcccattcc gaacacagaa gttaagctct ctagcgctga
      121 tggtacttgg tgggaaactg cctgggagag taggacgtag ccacgtaatt tttttgttat
      181 aataaattta gaatttaact tatatagttt aatttgataa tttgatgaaa aaaataaaag
      241 acttattgat ttttaaatct ataggtcttt tattttttat ctaacattta aattaagttg
      301 ttgaatatat cttatattac ttaccttata tattaattat cattaataca ttatatctaa
      361 ttactattca tctaaattat tatgccatta ttttatatac aaattctttt aatttatcta
      421 atccagataa gaaagtattt tcactgcaag cataggatat acgaatatat ttatccatac
      481 caaatgctat gccaggaaca actgcaacat tatattcttc taaaaattga ttacaaaatt
      541 ctatagaaaa actatcttta tattcaaatt tctcagatac tttagaaaga tctataaata
      601 tatagaatgc gccatttgga ttcacatatc ctacattatc aatagagtct agttttgatt
      661 taattaaatc tcttcttgat ttatatgttt taaccatatt gtctatgtca attgagcaat
      721 ctttcaaggc tccataggct atgtattgtg ctgttagact tgggtgagat ataagatgtc
      781 cttgtataga actcattgct ttagcaatcg ttttattaga tgcagtatat cctaatctta
      841 atccagtcat tgcagctgac ttagaaaaac catttatagt tattgttata tctttagctt
      901 cttcgcttaa tgatgcaatt gatgtaaatt caccagtgta gcatattttt tcatatattt
      961 catctgctaa aatatatatt ttattttgta tgcatacatc tactatttct attaattcat
     1021 cttttgtata aacactacca gtaggatttg aaggattgtt tattacaaga atttttgttt
     1081 tatctgttat agatttttca agttcttctt ttgttaactt aaatccattt tcttttttag
     1141 tatcaataaa aactggaaca gcattaacta acttaatcat ttcaggataa ctaacccaat
     1201 aaggctttgg taataagact tcatctcctt cgtctgttaa agctagtaaa gtatttgtta
     1261 ttgagttttt tgctccactt gatacaacta tttcgtctat tgaatagtta cagttatttt
     1321 cttcaataag ttttttacag atttcctctc taagtatttt taatcctgga actaaatcat
     1381 atttagtgta atctttattt aaagaatcaa taccataaga ttttgcgtta ttaggtacat
     1441 taaaatcggg ttctcctata ctaagattta ttactttaac tccattactt tccatttctt
     1501 taactttaga actaatacct attgtgtagg atggtgttat aaagtttagt ctttttgata
     1561 acataaaatg cctcctttta aattattatt tatattatac gacaaattta aagaatttac
     1621 ataaggaaat ttgtagatat atacattaat atatataata gcctacactt tttgcctaaa
     1681 attagtgtaa aaaaaagaga aaaaaatttt aactttcaaa gttgttagaa acgctactgt
     1741 tcaaaatatc cacatagtat ttgcaatgat ttgcgcaagt ttgactatta tgtacaaatt
     1801 tggtaatctt aatatagcaa ttattaagat aatcccttta acttagttga aggggatttt
     1861 tttagactta acatactaca tatagtggta tggggattaa taaaatacaa tatatagtaa
     1921 caggaggttt ttttaattgg ttgaattcgt aaaaaaaaga gatggaagag taattccatt
     1981 taatgaagat agaataacaa gagctatatt tttagcagca acgaatgttg cagaaagaga
     2041 aggaatagta cctgattata aattatctga gcaattaact caagaagtaa taaagttttt
     2101 aaatcataaa tactcagaat cagttccaag tgttgaagat atacaagatt ctgtagttaa
     2161 ggttcttata gaaactggcc atgcaaaaac tagtgaagaa tatataatat acagaactga
     2221 aagaagtaga ataagaaatt caaaaacaag gttgatgaag gcaatagagg aaattacctt
     2281 tgaagatgca gaagatgctg atataaaaag agaaaatgca aatattaatg gtaatacagc
     2341 aatgggaact atgttacaat atggaagcac tgtatctaaa gaattttgta aaacacatat
     2401 attaaaacca gagcattctt ttgctcatga taatggagat atacacatac atgatatgga
     2461 ttttttaaat atgggaacat taacttgttg tcaaatagat gttaaaaaac tattcaatgg
     2521 tggattttca acaggacatg gctttttaag agagccacaa gatataataa gttatggtgc
     2581 attagctgca attgctatac aaagcaatca aaacgatcaa catggaggtc aaagtatacc
     2641 atttttcgat tatggattgg ctgaaggtgt atataagaca tttaagaaat tctacatagg
     2701 aaatttagct aaagcattaa agttatttaa aggaattgaa aataatgatg tgataaagaa
     2761 catagtatat aatacagaga aagaaacaaa tcaaaaagtt ggtcttaaga gagatgaatt
     2821 gtatctaaac ttagaaaaag agaaattaat acagactttt gatatagatg atgaacttgt
     2881 aaataagatg caaaactttg catttgaaga atcgtataga gaaactgata aaaaaacata
     2941 tcaatctatg gaagcattta tacacaatct aaacacaatg cactctagag caggtgcaca
     3001 ggtaccattt tcaagtgtaa acttcggaac agatacttct gaagaaggaa gaatggtaac
     3061 taagaatctt ctattatctc aagaaagagg tttaggtaat ggagagacac caatttttcc
     3121 aattttaata tttaaggtca aagaaggcat aaatttaaat cctgaagacc ctaattatga
     3181 tttatttaaa ttatcatgca gagtatcagc taaaagacta ttccctaatt ttagtttttt
     3241 agatgcgcct tttaatgcaa aatattataa aaaaggtgaa ccagatacag aagctacata
     3301 tatgggttgt agaacaagag tacttagtaa tgtgtgtggt tcagaaacag ttagtggtag
     3361 aggaaacata tcttttacta cagtaaattt accaagattg ggtataaaac atggtattat
     3421 aaataatgaa aaggctaatt tagacggttt ctttgaagaa ttagatgaga agataaactt
     3481 aattatagaa caattattgg agcgccttga ggtacaagga aataaaaaga tgaagaattt
     3541 tccattctta atggggcaag gtgtatggaa aggttctgat gatttaggac cagaagatac
     3601 actaaaagaa gtaataaaac aaggaacatt gacaattgga tttataggtt tagcagagtg
     3661 ccttattgct cttataggta aacatcatgg agaaagtaaa gaagctcaag aattaggatt
     3721 aaaaatagtg tcacatatga gacataaaat ggatgaagca acggacaaat ataaattaaa
     3781 tttctcctta atgggtactc cagcagaagg tctttcaggt aggtttacta aaatagataa
     3841 aaaagtttat ggagaaatta aaggtatcac agataaagaa tattatacta attcattcca
     3901 tgtaccagtt tattacaata taagtgcata tgataaaatt gagatagaag ctccatacca
     3961 tgaattgact aatgcaggtc atataacata tgtagagtta gatggagatc catctgataa
     4021 tttagaagct tttgaaactg ttataaaagc tatgaaagat ttgggtatag gatatggaag
     4081 tataaatcat cctgtagata gagacccaat atgcggtttt tcaggtgtaa taacaagtaa
     4141 tatatgccct gtatgtggaa gaaatgaaga tgaaagtgat atcaaattcg aaagaataag
     4201 aagaataaca ggatatttag ttggtacagt tgatagattt aataatgcta aaaaagcaga
     4261 agtaagagat agagtaaaac atagatagtt ttatttgggg gaataagtta tgaaaataag
     4321 aatgtcatct actataagtt atgacagcat agttgatgga ccaggattaa gaatggtaat
     4381 atggacccaa ggatgtattc ataattgtaa agagtgccat aatcctcaga cacatgattt
     4441 atgtggagga ttttatatgg atacagaaga aattataaat aaagtcaaat cattgaaatt
     4501 acaaaaaggc attacgctat caggaggaga accattttta caaccagaac cattagaaga
     4561 aatagcaaaa gaagctaaaa taaatgggtt agatgtatgg tcatatactg gatttacgtt
     4621 tgaacaactg ttagataaaa aaaatagagc gtattttaaa aatttaaatt tactaaagca
     4681 aattgatatt ttagtggatg gaaaatttat agctgaaaaa aaagatataa gcttaaagtt
     4741 tagagggtca tcaaatcaaa ggataattga tgttcaaaaa agtttgaaat ataaacaagt
     4801 gtttttggtt gagcaatata tgaaggatga tttatctata gcagaataaa atataaataa
     4861 acaggattaa atatatgcat atatttaatc ctgtttattt tcatataata tttcaagctt
     4921 gtataatgta acaattaaac caaaagactc attgtatatt tgaaattaag ttttttatag
     4981 tttataggtg ttttatgtgg attacgaatg atatagtatt gatacattat ttaatagatt
     5041 cttatgccaa gaaacaatta atttatagaa attcttaatt gttacaatat aaatatctag
     5101 atatgttata agatactgat aaataattta taaagtttat taatctaata ttgtgtgtga
     5161 atattaagtg gtcaagtagt ctaaaaaatg aaaaagattt aaaaaagtgt tttaactaaa
     5221 cacataagtg ttaaattcat gtataagtat aggttagata cataagaaat aattatgtaa
     5281 tatctatctt tgtaaaaaaa tattaaattt tgtaatttgt ggataaatat gtttataatg
     5341 tggataatat ttaatgtaat aagttaaagc aatatgaatc aactgtttat aatgtggata
     5401 atattataaa tgtatgaata attgcagtat ttaaaaacaa aaaaagttaa aaaagttgtt
     5461 gactctaaaa gaaaaagttg gtatagtaat acttgtcctc aagaaaaggg caaacaaata
     5521 aagca
//
LOCUS       DAEPID010000145         5067 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.147, whole genome shotgun sequence.
ACCESSION   DAEPID010000145 DAEPID010000000
VERSION     DAEPID010000145.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 5067)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5067)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5067
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.147"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     regulatory      31..133
                     /regulatory_class="riboswitch"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00167"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="purine riboswitch; Derived by automated
                     computational analysis using gene prediction method:
                     cmsearch."
                     /bound_moiety="guanine and/or adenine"
                     /db_xref="RFAM:RF00167"
     gene            227..1603
                     /locus_tag="KR257_003679"
     CDS             227..1603
                     /locus_tag="KR257_003679"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003433141.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NCS2 family permease"
                     /protein_id="HBH0032334.1"
                     /translation="MQTTNSSTMQKLFPILTNKNVDMKKEIIAGVTTFLTMAYIIAVN
                     PNILSETGMPAGALVTGTCLAAAFGCILMGVVANLPFALASGMGLNAFFAYTVVLQMG
                     VPWEVALTAVFVEGIIFIVLSVSGVREAVVNAIPKNMKLAVTGGIGIFIALIGLVNSG
                     IVIGDQATLIKMGRFTPAVIITCVGLIIIAVLDKKRVKGSILFGIVVSSLLAWAFAFI
                     NPEYAQKLGIYLPGGLFKFESLAPIAGKIDLGYVLHPTNIGGFLVVVCTFLFVDFFDT
                     VGTLVGVCSKANMLDEKGNVPNVGRALLTDAVATTVGAGLGVSTVTTYVESSTGVIAG
                     GRTGWTAITVGILFLAAMFFSPVFIAIPSCATAPALIYVGYLMLGTVKDIEFDNITEG
                     VPAFVTIACMALTYSIGDGLTLGILTYVFVNIFYNIFGAKKAEDKKHVSVVMIVLAIL
                     FIIKLWLL"
     gene            complement(1717..2862)
                     /locus_tag="KR257_003680"
     CDS             complement(1717..2862)
                     /locus_tag="KR257_003680"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729122.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DEAD/DEAH box helicase"
                     /protein_id="HBH0032335.1"
                     /translation="MNTFEQLKISSTLIDGLKKQDITSPTEVQSLVIGNIIQNKDLLI
                     NSQTGTGKTLAYLLPIFEKIDTSKRETQALILAPTHELVMQITNQVELLAKNAELSVT
                     SLALIGEVNIQKQIKNIKAVKPHIVIGSCGRVLDLIKQKKLKSHNIKTIVLDEVDNLL
                     NGKNITCIEDIIRTTLRDRQIIGCSASLTDSTIKICDKLMKEFEIIKTKEKSQINPNI
                     NHSYLLGEIRDKFTFLRKALAATNPKKAIVFVNNEKNIEVLVSKLNYHNYKAIGIFGN
                     MEKEDRKNAINKFKLGKAKILITTDLSARGLDIVDVSHVFNLDFPKSKNEYLHRCGRT
                     ARGNRSGNTISIITKKELDIIKDLQKEFNIVITPKTLQNGELIDIIK"
     gene            3115..3822
                     /locus_tag="KR257_003681"
     CDS             3115..3822
                     /locus_tag="KR257_003681"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430631.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBH0032336.1"
                     /translation="MLKVINVSKSYKNKKVVSSVSFDVNDGELFGFIGHNGAGKTTTI
                     KAIVGIHDFEEGEVLINSKSIKKQPVECKKEMAYIPDNPDLYESLTGIQYLNFIADIF
                     EVAKDKREELIKYYSNKFELNKALGDLISSYSHGMKQKLAIISALIHSPKILILDEPF
                     VGLDPKASFILKEIMREFCDKGGCIFFSTHVLEVAEKICDKIAIIKDGNIIAYGTTEE
                     VKGSNSLESIFMELIEK"
     gene            3869..>5067
                     /locus_tag="KR257_003682"
     CDS             3869..>5067
                     /locus_tag="KR257_003682"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434052.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBH0032337.1"
                     /translation="MSNLSILIKTNIINEFKLNALKKADGREKQKIMGMMLSVVIIAG
                     LLIFYVTSLSLSLVDILKQINQLEMLLIFGFGLSTLTTIVTSLYKTSSYLFQAKDLDL
                     LTSLPIKESTVLASKILMLVGANYLFSSICMLIPAVVYFLNSDVSITYFPYLILLFLA
                     LPLLPIVASSIIFLFIGQISSRIKYKNLVLIIGSIILMLLYTLLMSRLNSMSVEMLKN
                     SVSISETIRKVYPPIYYFVDALKTGSIVSFLAFIAISIIPFFMFVTLFAKKFKDINAK
                     MSEGYKSKNYEFKGQKTSRPSKALLKKEFKRYTSSFIYFLNSSAGLLFLIVGTILILL
                     FGADKVGELLKLNIDFNLIKIQLLGVFFFIIVMNCTTYCSISLEGKNLWILKSSPIDE
                     REIFWSK"
BASE COUNT         1704 a          613 c          797 g         1953 t
ORIGIN      
        1 tataaattaa aataatattc gtaaagaaaa attcatgttt tgtactgtat aacatataat
       61 tttgacaata tgggtcataa gtttctaccg gaataccgta aatattctga ctatgtatac
      121 tattatttag ttaattaaat atttaattaa ctgaattatg aaggatacgg ctcagcttat
      181 caactactgt gtcgtttttt tgtaaaattt aataggaggt gttgttatgc aaacaacaaa
      241 cagtagtact atgcagaaac tttttccaat tttgactaat aaaaatgtcg acatgaagaa
      301 ggaaataatt gcaggagtaa ctactttttt aactatggct tatataatag ctgtaaatcc
      361 aaatatttta tctgagacag gcatgcctgc aggtgcactt gttacaggta cttgtttagc
      421 agcagcattt ggatgtattt taatgggtgt agttgctaac cttccttttg ctttagcatc
      481 aggtatgggt cttaatgcat tttttgcata tacagtagtt ttacaaatgg gtgttccttg
      541 ggaagtagct cttacagcag tatttgtaga aggtattatt tttatagtat tatcagtaag
      601 tggagttcgt gaggctgttg taaatgcgat accaaaaaat atgaaattag ctgttacagg
      661 tggtatagga atatttattg cacttatagg tctagttaac agtggaattg ttattggaga
      721 ccaagccact cttatcaaaa tgggtagatt tacaccagca gtaataataa cttgtgtagg
      781 attaataatt attgctgtat tagataaaaa aagagttaaa ggttctatac tttttggaat
      841 agtagtgagt tcattacttg cttgggcatt tgcttttata aatccagagt atgcacaaaa
      901 attaggtata tatttacctg gtggattatt taaattcgaa agtttagcac caatagcagg
      961 taaaatagat ttaggatatg tactacatcc aacaaatata ggtggttttt tagtagtagt
     1021 ttgtacattt ttatttgttg atttttttga tacagtaggt acattagttg gtgtttgttc
     1081 taaagcaaac atgttagatg aaaaagggaa tgttcctaat gtaggtagag ccttacttac
     1141 agatgcggtt gcaactacag ttggtgcagg acttggagta tctacagtta caacttatgt
     1201 tgagagttca acaggagtta tcgcaggtgg aagaactgga tggacagcaa taacagttgg
     1261 aattttattc ttagctgcaa tgtttttctc tcctgtattt atagcaattc catcatgtgc
     1321 tacagcacca gctttaatat atgttggata tttaatgctt ggtacagtta aggatataga
     1381 gtttgataat ataactgaag gtgttccagc ttttgttact attgcttgta tggcattaac
     1441 atatagtata ggtgatggtt taactttagg tatattaact tatgttttcg taaatatatt
     1501 ttataatata tttggagcta aaaaggcaga agacaaaaaa catgtttctg tagtaatgat
     1561 tgttctggca atattattta taataaaact ttggctacta taataggtat tatttaaaat
     1621 tttaatttaa tataaaataa agggctgtaa tttattatca attgtgatga taaactacag
     1681 ctcttttgta tttgttgtat ttttgtattt attgtattat ttaataatgt ctattagttc
     1741 tccattttgt aaagttttag gtgtaattac tatattgaac tctttttgca aatcttttat
     1801 aatatctaat tctttttttg ttattattga gattgtgtta ccacttcgat ttcctctagc
     1861 agttcgacca catctatgca ggtattcatt tttacttttt ggaaaatcca agttaaaaac
     1921 atgacttaca tccacaatat ctagtccacg agcagataaa tcagttgtaa ttaaaatctt
     1981 tgctttacca agtttaaatt tatttattgc attctttcta tcttcttttt ccatatttcc
     2041 aaaaattcct attgctttgt aattatgata atttagtttt gatactagga cttctatatt
     2101 tttttcatta tttacaaata caatagcttt ttttggattt gtagctgcta atgcctttct
     2161 aagaaaagta aatttatccc ttatctcacc taataaatat gagtgattga tgttaggatt
     2221 tatttgtgat ttttcctttg tttttattat ttcaaactcc ttcataagtt tatcacaaat
     2281 ttttatagtg ctatcagtaa gacttgcaga gcatcctata atttgtctat ctcttaacgt
     2341 tgttcttatt atgtcttcta tacaagttat attttttcca ttcaatagat tgtccacttc
     2401 atctaagaca atagttttta tattatgtga ttttagtttc ttttgtttta tcaagtctaa
     2461 aactcttcca caagagccaa ttactatgtg tggttttact gcttttatat tttttatttg
     2521 tttttgtata ttgacctccc caattaaagc taaagaagta acggagagtt ctgcattttt
     2581 agccaataat tcaacctggt ttgtaatctg cattactaat tcatgcgtag gtgcaagtat
     2641 aagagcttgt gtttctcttt ttgatgtatc aattttttca aatataggta aaaggtacgc
     2701 tagtgttttt cctgttccag tctgtgaatt aatcaataaa tccttatttt gaattatatt
     2761 ccctataaca agtgactgaa cttctgttgg agaagttatg tcttgttttt tgagtccatc
     2821 tattagagtg gaacttattt ttaattgttc aaatgtattc atattttact ccttatattt
     2881 taataattat agtcaactat tttttattat acattgttta ttcaaatcga actatatatt
     2941 cttttataat tatgtgtaat ttgaaagtaa atatcaatta tatttatacc tttatatttc
     3001 tgataccttt gcattttata gatttctaaa ataaacaaat aaaagttgta attgtttgat
     3061 atttgttata tattgtatat aacaaatatc aaaactataa tatggaggga aattatgtta
     3121 aaagtaatca atgtatctaa atcatataaa aataaaaaag tagtaagtag tgtctcattt
     3181 gatgtaaatg atggagagct ttttgggttt ataggacata atggagcagg taaaactact
     3241 actattaaag caattgttgg aatacacgat tttgaagagg gagaagtact aataaattct
     3301 aaatctataa aaaaacagcc tgttgaatgt aaaaaggaaa tggcatatat acctgataat
     3361 ccagatttat acgagtcatt aactggtata caatacctta attttatagc tgacatattt
     3421 gaagttgcca aagataaaag agaagagtta ataaaatatt attcaaataa gtttgaactc
     3481 aataaagcat taggagattt aatatcttca tattcgcatg gtatgaaaca aaaattagct
     3541 ataatttcgg ctttgataca cagtccaaaa atcttaattc ttgatgaacc ttttgtaggt
     3601 cttgacccaa aagcttcctt tatattgaag gaaattatga gggagttttg tgacaaaggt
     3661 ggttgtatat ttttctcaac acacgtttta gaagttgctg aaaaaatttg tgataagatt
     3721 gccataataa aagatggaaa tataattgct tatggaacta cagaagaagt taagggaagt
     3781 aattcacttg aaagtatctt tatggaatta atagagaaat aaaatgtttt ttatacaata
     3841 tagtgtctaa agtgaggaat gataaaatat gagcaatcta agtatattaa taaaaactaa
     3901 tataataaat gaatttaaat taaatgcgtt aaaaaaagct gatggtagag aaaaacaaaa
     3961 aataatggga atgatgcttt cagttgttat aatagcgggt ctattaattt tttatgtaac
     4021 aagcttaagt ctctctttag ttgatatctt aaagcaaata aatcaactgg aaatgctact
     4081 gatatttggt tttggattat caacattaac aactattgtt acatcattat ataaaacgtc
     4141 atcatatcta tttcaagcaa aagatttaga ccttttgact agtttaccta taaaagaatc
     4201 tactgtacta gcaagtaaga tattaatgtt ggttggagca aactatttat tttcttcaat
     4261 atgtatgctt atacctgcag tggtttactt tttaaattct gatgtaagta taacttattt
     4321 cccttatttg atattgctat ttttagcttt accattatta ccgatagttg cttcatcaat
     4381 aatttttcta tttatagggc agatatcatc aagaataaaa tacaaaaatt tagtattaat
     4441 cataggtagc attatattga tgttgcttta taccctactt atgtcaagac ttaattctat
     4501 gtcagttgaa atgctaaaga atagtgtgtc tatttcagag acgattagaa aagtatatcc
     4561 tcctatatat tattttgttg atgctcttaa aacaggaagt atagtttcat ttttagcatt
     4621 tatagccatc tcaataatac cattttttat gtttgtaact ctgtttgcaa aaaaatttaa
     4681 agatataaat gctaagatga gtgaaggata taagtcaaaa aattatgaat ttaagggtca
     4741 aaaaacttca agaccttcaa aagctttatt aaaaaaagaa tttaagagat atacttcttc
     4801 gtttatatac tttttaaatt catctgcagg tttgttattt ctaatagtag gtacaatttt
     4861 aatattatta tttggagcag ataaagtggg tgagttactg aaattgaata tagattttaa
     4921 tcttataaaa atacaattat tgggagtatt cttctttata atagtaatga attgtacaac
     4981 atactgttca atttctcttg aaggaaaaaa cttatggata ctgaaatctt ctccaataga
     5041 tgaaagagaa atattctggt caaaaat
//
LOCUS       DAEPID010000146         4902 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.148, whole genome shotgun sequence.
ACCESSION   DAEPID010000146 DAEPID010000000
VERSION     DAEPID010000146.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 4902)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4902)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4902
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.148"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            550..1410
                     /locus_tag="KR257_003683"
     CDS             550..1410
                     /locus_tag="KR257_003683"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891460.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PRD domain-containing protein"
                     /protein_id="HBH0032338.1"
                     /translation="MKIIQILNNNVALVKRGKNEIIVFVKGIGFKKRVGQVINENEIE
                     RTYILDSYDMLEHFSYLLQNSDSNNIVLINEIIEYGEKALNIKASDYLSLTLLDHLEF
                     LLKRCEKNQFIKSPLVWNVKRFYPKHFEIGMHALKLIGDSKGINLPDDEAVSIALHFV
                     NMEVNKESHDSTIVELRTLADIVSIIKYHFNVELDETSTNYMRFTTHLQYFIQRIMSD
                     EASIDEDNSIDLYKQVSQLYPKSFGSVQKIRKYIKSQFNVDISISEETYLMLHINRVT
                     QRLEAKSDEI"
     gene            1400..3271
                     /locus_tag="KR257_003684"
     CDS             1400..3271
                     /locus_tag="KR257_003684"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003427323.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS glucose transporter subunit IIA"
                     /protein_id="HBH0032339.1"
                     /translation="MKYKDLNENIIKLIGGKENIKSVAHCVTRLRFTLNDRSIAQTEE
                     IKKLKGVIDVVSNDVAYQIIIGTHVVDVYNEFMSMIGLSSSESSIKSERKKGIRGIKG
                     IFNSIFVVVSETMTSVIEVLLAAGILASILALLNMSGILQSDSPTYQILDTLRSATFH
                     FLPVLIAIASAKRLNVNPYIAVVLAVTLLSSSIDGVEGLSLFGINLQATTYANSFIPI
                     LLGVWAMGIIIEGLKKILPKALHYFLVPVLSLIITLSVTLTVFGPIGMWIGDGLNYAC
                     MFLIDTLGNWSVVALYAALQPLLIVFGAANFTMPISLNSVTTLGYDPIFMGAATISDI
                     AVCGAMFGYFLKTRNKEQKQLFGTVSFSALMGVTEPSVFGVFMKYRRPFVAVMIGGGI
                     GGLIAGLAQVKTYGMVWGLAALPTYLVGGEVSNFTFMIISVVVSFVAATAASYLLGIP
                     SDEKEEVKGDNEKELELIINENNSRTISIGNVAKGQVIALGEVNDKAFSSGALGKGVG
                     VIPSESKSTVISPVDGTITIVFPTKHAYGIVTDEGLEILIHIGIDTVNLDGKFFESLV
                     TQNQRVKKGDALAVFESDKIIEEGFDSTIITVVTNTSDYLDVISSNDESEELLTVIV"
     gene            3291..4745
                     /locus_tag="KR257_003685"
     CDS             3291..4745
                     /locus_tag="KR257_003685"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003440025.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="family 1 glycosylhydrolase"
                     /protein_id="HBH0032340.1"
                     /translation="MNIKDTFFWGGSIAAHQCEGSWDSDNKGPAIMDFVTKGSYETPR
                     VITDKIEEKLDYPSHNGIDFYNRYKEDIALFKEMGFSALRISIDWSRIFPNGDDENPN
                     ELGIKYYEGLIDTLIENNIEPIVTLYHFELPMNLVHKYGSWNNRKLIDLYLKYSETVI
                     RRFDDKVKYWVTFNEMNHIDPQTEHSDIFTYMIAGIKYSEIENKVQTLANVGYNMTLA
                     GVKVAKLAREINPNNKIGCVFGLNPIYPYNCNPSNVLNAFLDNDRDYYQIDAMCNGKF
                     PQYKLKEYEKNNITIEVTDEDKKAFKEGKLDFIGLNYYFSSVSTPKENLSGDKSLFGG
                     IQNPYLEQSKWGWAIDPIGLRFTLNYIYRKYQLPILITENGLGAYDKIEEDGTINDDY
                     RIEYLSKHLSQMKSAIEEDNVECFGYLMWGPIDLVSATTGQMSKRYGFIYVDLDDEGK
                     GSFKRYKKKSFDWYKEVIKSNGEVLDFSTDIVVG"
BASE COUNT         1884 a          515 c          896 g         1607 t
ORIGIN      
        1 atcttactag tgtttaaata aaactaaatt taagtattta tatattagta tatcttacta
       61 gcatttaaat gaaactaaat ttgaagcttt acctattaat atatcttaat agtgattaaa
      121 taaaactaaa cttaagactt tatatgttaa tatatcttaa gaatttattt gttaacatac
      181 agttcattat atttaaaagc attactatga taattcataa tagtaaaata gataatggtt
      241 cagacaatat tataaatatt agtgacggta aaatagtatc aatttagtat ataaaccttg
      301 tcagataatc gcataacaga gcttgtagtt atagaataaa aaaatatcta ggaaaccgtt
      361 gacagattta tatggatagt ataacatata gaatatgaaa ttaaacaaaa aagaatttta
      421 attatggcga cgtagtcata attttgagta tgttactgat tagcaggcag aactcaagta
      481 tatatgtgaa aaatagaggg atactctata catatatgct tgagttcttt ttattgaaag
      541 gaggaatata tgaaaataat tcagatttta aataataatg tagccttagt aaaaagaggt
      601 aaaaatgaaa ttattgtatt tgttaaagga attggcttta aaaaaagagt gggacaagta
      661 ataaatgaaa atgaaataga gagaacatat atactagatt catacgatat gctagaacac
      721 tttagttatc tactacaaaa ctcagactcc aataatatag ttcttattaa tgaaataatt
      781 gaatatggtg agaaagcttt aaatataaag gcaagtgatt atctaagctt aaccttacta
      841 gaccatttag agtttttact taaaagatgt gaaaagaatc aatttataaa aagtcctttg
      901 gtatggaatg ttaaaagatt ttatccaaag cattttgaaa ttggaatgca tgcactaaaa
      961 ttaattggtg atagtaaggg aattaatctt cctgatgatg aggcagtatc aatagcactt
     1021 cattttgtaa atatggaggt aaataaagag tctcatgata gtacaattgt agagttgaga
     1081 actttagcag atatagtttc tataataaaa tatcatttta atgtagagct agatgaaact
     1141 tcaacaaatt atatgagatt tactactcat ctacagtact ttatccaaag aattatgtcg
     1201 gatgaagctt caatagatga agataattct atagatttat ataaacaagt aagtcaactt
     1261 tatccaaagt catttggaag tgttcaaaag ataagaaaat atataaaatc acaatttaat
     1321 gtcgatatat ctataagtga agaaacttat ttaatgttgc atataaatag ggtgactcaa
     1381 agactggagg caaaatcaga tgaaatataa agatttaaat gaaaatataa taaaacttat
     1441 agggggaaaa gaaaatataa agtcggtagc gcattgtgtt actcgtttaa gatttacttt
     1501 aaatgatagg agtatcgctc aaacagaaga aattaaaaaa ttaaaaggag taattgatgt
     1561 agtttctaat gatgttgctt atcaaattat aataggtact catgttgtag atgtatataa
     1621 cgagtttatg tctatgatag gtttaagttc aagtgaatca agtataaaaa gtgaaagaaa
     1681 aaagggaatt agaggtatca aaggtatatt taattccatc tttgtggtag tctcagagac
     1741 tatgacttca gtaattgaag tactacttgc agctggtata cttgcaagta tattagcact
     1801 tttaaatatg tctggcatac ttcagagtga cagtcctaca tatcaaatat tagatacatt
     1861 aagaagtgct acatttcact tcttaccagt attaattgca atagcatcag caaaaagact
     1921 taatgtaaat ccctatatag cagtagtgtt agcagttacg ttattatctt catcaataga
     1981 tggtgtagaa ggattaagtt tatttggtat aaatttacag gctacaactt atgcaaacag
     2041 ttttattcca atacttttag gagtatgggc aatgggaatt ataattgaag gtttgaaaaa
     2101 aatattacct aaagcattac actatttttt agttccagtg ttatctttaa taataactct
     2161 atcagttaca ttaactgtat ttggacctat tggtatgtgg attggtgatg gattaaacta
     2221 tgcatgtatg tttttaattg atacattggg taattggagt gttgttgcac tgtatgcagc
     2281 tttacaacca ctcttaatag tttttggtgc agcaaacttt actatgccta tatctttaaa
     2341 ttctgtgaca acattggggt atgacccaat ttttatgggc gctgcaacaa tatctgatat
     2401 tgcagtttgt ggtgcaatgt ttggatattt cttaaaaact aggaataaag aacaaaaaca
     2461 actatttggt acagtaagtt ttagtgcact tatgggagtt acagaacctt cagtgtttgg
     2521 tgtgtttatg aaatatagaa gaccatttgt agcagtaatg ataggtggag gtataggtgg
     2581 tttaatagca ggtttagctc aagttaaaac atatggaatg gtttggggat tagctgcatt
     2641 accaacgtat cttgttggag gagaggtatc taactttaca tttatgataa taagtgtagt
     2701 agtatcattt gtagcagcaa cagcagcttc ctatttacta ggaatacctt cagatgaaaa
     2761 agaagaagtt aagggtgata atgaaaaaga attagaacta ataatcaacg agaacaattc
     2821 aagaactatt agtattggaa atgttgcaaa aggtcaggta attgcacttg gggaagttaa
     2881 tgacaaagca ttttcctctg gagcattagg taaaggggtt ggagttatac ctagtgaatc
     2941 aaaatcaact gttatatctc ctgtagatgg aactataact atagtatttc caactaaaca
     3001 tgcatatggt atagtgactg atgaaggatt agaaatatta attcatattg ggatagatac
     3061 tgtaaactta gatggaaaat tctttgaaag tcttgtaaca caaaatcaaa gggttaaaaa
     3121 aggagatgct ttagcagtat ttgaatctga taaaattata gaggaaggct ttgattctac
     3181 tataataact gtagttacaa atactagcga ttatttagat gtaatctcat caaatgatga
     3241 atcagaagaa ttattaactg taatagtata aattttagga gggaaaattc atgaatatta
     3301 aagatacatt tttctgggga ggaagtattg cagcccatca atgtgaaggt tcatgggata
     3361 gtgataacaa aggacctgca attatggact ttgtaactaa gggctcttat gaaacgccaa
     3421 gagtaattac tgataaaata gaagaaaaat tagattatcc atctcataat ggaatagatt
     3481 tttataatag atataaagaa gatatagctt tatttaaaga aatgggattt agtgcattaa
     3541 gaatatctat agattggtca agaatttttc caaatggaga tgatgaaaat cctaatgaat
     3601 tagggattaa atactatgaa ggtctgatag atacattaat agaaaataat atagaaccta
     3661 ttgtaacact atatcatttt gaattaccta tgaatttagt acataaatat ggttcatgga
     3721 ataacagaaa acttatagat ttgtatttaa agtacagtga gactgtaata agaagatttg
     3781 atgataaggt aaagtactgg gttacattta atgagatgaa ccatattgac cctcaaacag
     3841 agcactcgga tatttttact tatatgatag caggtattaa gtatagtgaa atagaaaata
     3901 aggttcaaac attggcaaat gtagggtata atatgacttt ggcgggtgta aaggttgcaa
     3961 agttggctag agaaatcaat cccaacaata aaattggatg tgtatttgga ctaaatccaa
     4021 tttatccata caattgtaat cctagtaatg tgttaaatgc atttttagat aatgaccgtg
     4081 attattatca aattgatgca atgtgcaatg ggaagtttcc acaatataaa ttaaaagaat
     4141 atgaaaaaaa taatataact attgaagtga ctgatgaaga caaaaaagca tttaaagaag
     4201 gtaagttaga ttttatagga cttaattatt atttttcaag tgtatctact ccaaaagaaa
     4261 atttatcagg tgataaatct ttatttggtg ggattcaaaa tccatatttg gaacaaagta
     4321 agtgggggtg ggcaatagac cctataggtt taagatttac cttgaactat atttacagaa
     4381 agtatcaatt acctatctta attacagaaa atggtttagg ggcatatgat aaaatcgaag
     4441 aagatggaac tataaatgat gattatagaa ttgaatattt aagtaagcat ctatctcaaa
     4501 tgaagtctgc aattgaagaa gataatgttg aatgttttgg atatttgatg tggggaccaa
     4561 ttgatttagt cagtgcaact acaggtcaga tgagtaagag atatggattt atctatgttg
     4621 acttagatga tgaaggcaaa ggaagtttta agagatataa gaaaaaatca tttgattggt
     4681 acaaagaagt aataaaatct aatggagaag ttttagattt ttctacggat atagtagtag
     4741 ggtaggaata agataaatag aagttaggaa ctaatgttaa ttagtgtcta gtaaagcatt
     4801 taaaatagag tatagggtct ttaaagtaaa gtgtgtattc ttcttaaaaa taatggcaat
     4861 taaaattact ataaaaagga gaatacacat tttttatttt ta
//
LOCUS       DAEPID010000147         4779 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.150, whole genome shotgun sequence.
ACCESSION   DAEPID010000147 DAEPID010000000
VERSION     DAEPID010000147.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 4779)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4779)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4779
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.150"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            182..1321
                     /locus_tag="KR257_003686"
     CDS             182..1321
                     /locus_tag="KR257_003686"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728737.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Fic family protein"
                     /protein_id="HBH0032341.1"
                     /translation="MVIKLTIEEYKNKYFTGNKIVLSINSFDNKELYYHETENILNLI
                     NEIDKLTSSKIFKTIEDKNDLALESYYSSVIEGAFSTRKIAKSIIRGKMKPSNKSEYM
                     IYNNHRALEYGLDNLDKLYSHKFIYDLHHILGENCLDSEEYEYRTEKVYVCDSKGEII
                     HTGLEPLKIYDFMSKLIDFMENSKVSNLIKSAIIHFYFVYVHPFSDGNGRTSRALSYL
                     YLIDKGYDTFKDFSISYMISKNRTKYYKAILDVENKGNNLTVFIEFMLKSIIQSINEM
                     RNMHDRKSLESILKEELFENDITLSATEEHILKYICNKDNYSMTLENYIKKNKSRYLK
                     AGIKEIELVDQLMEVFNNLEEIEILSKEKNIYKVNDKYLKMLDID"
     gene            1347..1535
                     /locus_tag="KR257_003687"
     CDS             1347..1535
                     /locus_tag="KR257_003687"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426367.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0032342.1"
                     /translation="MNNKKKAFLISGAINVISLIIVFSLFHYNIIENSTQNMIITVIL
                     IFIFEMIKIKIIEKYYKL"
     gene            2320..3876
                     /locus_tag="KR257_003688"
                     /pseudo
     CDS             2320..3876
                     /locus_tag="KR257_003688"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860844.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="cell wall-binding protein CwpV"
BASE COUNT         2102 a          509 c          819 g         1349 t
ORIGIN      
        1 taatagttgt aaacttcctg tgacatatat tttaaatgct tattcttaaa tttttgcatt
       61 atttattaaa atttattatg ctttaacgct aaattgagtt tgataattat aaaacaaata
      121 atcaaaaata gtgtaaaaat taatactttt tgttaatatt aatagataaa gataatctaa
      181 ggtggtgatt aaactgacaa tagaagaata caaaaacaaa tactttactg gaaataaaat
      241 cgtactttct ataaatagtt ttgataataa agaactatac tatcatgaaa ctgaaaatat
      301 attaaattta ataaatgaaa tagataaatt aacatcaagt aagatattta aaacaataga
      361 agataaaaat gatttggcac tagagtctta ttattctagt gtaatagaag gtgctttttc
      421 aactagaaag attgcaaaat ctataattag aggaaagatg aaaccaagta ataaaagtga
      481 atatatgatt tacaataatc atagagcctt agaatatgga ttagacaact tagataaatt
      541 atatagtcac aaatttatat atgatttgca tcatatattg ggcgaaaact gcttggattc
      601 agaagaatat gagtatagaa ctgaaaaagt atatgtatgt gattcaaaag gtgagattat
      661 acatacaggg cttgaacctt tgaagatata tgactttatg agtaaattaa tagattttat
      721 ggaaaatagc aaagtaagta atttaattaa aagtgctata attcattttt actttgtata
      781 tgttcatcct tttagtgatg gtaatggaag aacatcaaga gccttatcat atctatattt
      841 gattgataaa ggatatgata ctttcaagga tttttcaata tcatatatga tatctaaaaa
      901 cagaactaag tattataagg ctatacttga tgtagaaaac aaaggaaata atttaactgt
      961 atttatagaa tttatgctca agtctataat acaatctatt aatgagatgc gtaatatgca
     1021 tgatagaaaa tctttagaaa gtatattaaa agaagaattg tttgaaaatg acataactct
     1081 atcagcaaca gaagaacata tattaaaata tatttgcaat aaagataact attctatgac
     1141 attagaaaat tatataaaaa agaataaaag tagatactta aaggctggaa taaaggaaat
     1201 tgaattagtt gaccagttga tggaagtgtt taataatctt gaagagatag agattttgtc
     1261 taaagaaaaa aatatatata aagttaatga taagtactta aaaatgcttg atatagacta
     1321 atttagataa tctggagagg gaatatatga ataataagaa aaaggcattt ttgatttctg
     1381 gggctataaa cgtaatttca ttaattattg ttttttcatt gtttcattat aatattatag
     1441 aaaatagtac acaaaatatg ataataactg taatcttaat ttttattttt gaaatgataa
     1501 aaataaaaat catagagaaa tactataaac tataaacaag aaatatcttt tctaagagca
     1561 tattgtacaa tatgctctta atttagttat atagatttaa tataaataat gtattttttg
     1621 tagatgattt atgtaagatt tatgaccaat ttgtgtatga tttgtgttct ttaatcatga
     1681 caatattata ttgtaaaaaa taaatttaat aaaaaatgac ttggaattta tattctaggt
     1741 cttttttata taaaaattta ataagtttca aatgttggta actttgacag tagaaaacgt
     1801 ctattgagat aacgaggatt ctaattgagg gggagagata ttagcactta aagtagtata
     1861 tgcaacagat ataatcttta caaaagtaat ttgaattaaa atgtaaatat aaagaataat
     1921 taaaaaaata tcgcaattat ttgtttttca tatggataaa attggttatt taatatataa
     1981 ttacaagtat aaataataaa atttatttgt aaaaagagta gcacttttaa ttcataaagg
     2041 ctactttttt tatacaaaac cctatttttt ataacaattc attaacataa aaatcaaact
     2101 taccttaaaa tataaattta caaatttttc aatcaataag aaaatttctt tattccttac
     2161 ataatgactg caatgtaaca aaataattac aaattaatta tgaaatcatt atagttagaa
     2221 acctctttaa aattagatat taagtatcct ttagaattag aacgggaaca aagttaaaaa
     2281 attaagtaat atcaaatgga caagggggaa gaaaataaaa tgaaaatacc aaagaagatt
     2341 gctgcaatgc ttacagttac aatgatagct ggaagttcaa cagcaggcat agctagtgca
     2401 caaactgtgg caacaaattt aacagggcaa gaaagatatg aaactgctgt taaaataagt
     2461 caagatggat ggaaaaatgc tgatgaggta gtaatcgtaa acgactcatc tatagcagat
     2521 gctctatctg caacaccatt tgcaaaagca aaaaatgctc caatactttt aacaagtaaa
     2581 gataaattaa atgataagac gaaagcagaa atacaaagat taaaagctaa aaaagtatac
     2641 ttaataggtg gaacttctgt attaagtaca aatatagaaa aagaaataaa agatttaaaa
     2701 atatcttttg agagaatctc tggagctgag agatatcaaa catccttaga attagcaaag
     2761 aaattagatg ctataagtga tgttaagaaa atagctgtag ttaatggtga aaaaggactt
     2821 gcagatgctg taagtgtagg agcaccagct gcacaaaaca atatgccagt aatacttgct
     2881 gattctaaaa atggaacagc agttgcagac aaatttataa aagatgctgg aataactcaa
     2941 tcttatgtag taggtggaga gagttcaatt tctgaagctg ttaaaaataa actaccaaat
     3001 agtacaagac taggtggaac agatagaaat gatacaaatg caaaagtaat aaaagaattt
     3061 tataaaaaga cagatttaaa aaatgcttat gtaactaaag atggtatgaa taaacaagac
     3121 caacttatag atgcactagc agtaggtgta ttaggtgcta aaaatcaatc accagtagtt
     3181 ttagttggaa agaacttatc agcttcacaa aaatctctag ttaactctaa gagttttgat
     3241 aagataacta aagttggtgg gaatggtaat gagacagcat ttaatgaaat gaagtcatta
     3301 caagaagtaa aaacagttga agctaaaaca atttctgaat taaaatcagc tatagataaa
     3361 gctactgcta atgatgttat aaactttaag ccaactagtg aggttaaaga agcatttaca
     3421 atacaaactg ataaagcagt aacagtaaac ttaaatggta catatacaaa gactgtaact
     3481 atcaacatgc ctaatggaga tgtaaataac tatgcaaaag tggatgatgt agttatagat
     3541 gatgtaaaag atggaacttt tgttaactat ggaaaaataa ctaacttaaa ggttaatgat
     3601 aaaaatggag ccaagataga aaataattct aaaggtgaga ttggtagttt aacagtagca
     3661 tctggagcaa gtcaagtaaa agtgactaat ggtggtaaga taactacagt tacaaataat
     3721 tctaaaggga ctactataga taataaaggt acaataagta gtgttaaggg agataattct
     3781 ccaacaataa gtggaaatag tccaagttct aactcttcag gaggaagttc atcaagtgga
     3841 ggctcttcac atggaggagg aagttcttca tcaaaaccaa gcgataagtc aaaaacaaag
     3901 acaaaagcag aagaaaaaat agcagaggta acaaaactag taggaaaagt aacagcagat
     3961 aatttagaag catcaaaagt aacattaaaa gcagcaactg atgcaataga agaagcaagg
     4021 aaagcagggt ggacagaatc agaagttcaa agctttaaag gatatggaga tatagcaaaa
     4081 gtacaaagtg agataactga attagaatca caggctaaag aagcagcaaa gacaaaagca
     4141 gaagaaaaaa tagcagaagt aacaaaacta gtaggaaaag taacagcaga taatttagaa
     4201 gcatcaaaag taacattaaa agcagcaact gatgcaatag aagaagcaaa ggcagcagga
     4261 tggacagaat cagaagttca aagttttgca ggatatgaag atatagcaac agtacaaggt
     4321 gagatagctg cattagaatc atcacaggct aaagaagaag caaagacaaa agcagaagaa
     4381 aaaatagcag aagtaacaaa actagtagga aaagtaacag cagaaaattt agaagcatca
     4441 aaagtaacat taaaagcggc aactgatgca atagaagaag caaaggcagc aggatggaca
     4501 gaatcagaaa ttcaaagttt tgtaggatat gaagatatag caaaagtaca aagtgagata
     4561 actgaattag aatcacaggc taaagaagca gcaaagacaa aagcagaaga aaaaatagca
     4621 gaagtaacaa aactagtagg aaaagtaaca gcagaaaatt tagaagcatc aaaagcaaca
     4681 ttaaaagcgg caactgatgc aatagaagaa gcaaaggcag cagggtggac agaatcagaa
     4741 gttcaaagtt ttgcaggata tggagatata gcaaaagta
//
LOCUS       DAEPID010000148         4778 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.151, whole genome shotgun sequence.
ACCESSION   DAEPID010000148 DAEPID010000000
VERSION     DAEPID010000148.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 4778)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4778)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4778
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.151"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            <1..123
                     /locus_tag="KR257_003689"
     CDS             <1..123
                     /locus_tag="KR257_003689"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888399.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
                     /protein_id="HBH0032343.1"
                     /translation="KNLNIREWICPSCNETHDRDINASINILKEGLRLITIQNK"
     gene            250..1419
                     /locus_tag="KR257_003690"
     CDS             250..1419
                     /locus_tag="KR257_003690"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896859.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hydantoinase/oxoprolinase family protein"
                     /protein_id="HBH0032344.1"
                     /translation="MNELCKDEVVEFCNRIKGKVESVAISGVFAPVNKQQEEEVAKWV
                     REILGDIPISLSNEIGNIGILERENGAILNSALSQVGKAVSLGFEKALKDLGIDAQIY
                     FSQNDGTLMNLEYTMKYPIFTIGCGITNSIRGASFLSKVKNAIVLDVGGTTSDLGVLY
                     NGFPRESSIPVTIGGVHTNFRMPDVLTIGLAGGTCVKGEKDNIKIGPESVGYRITEDA
                     IIFGGDTLTLSDVVTKLDMAFEDRKSNVENLDKEYCNEVYKKVILKLEDAVDQMKTSQ
                     DDVELVLTGGGSIIVPEKLKGISNVIRPPHYTAANAIGAALGQISGDVEKVYSLDKMS
                     REDAIEDAKKEAVNKALKAGAKEDTIEVLNIEDVPLAYLPGNALLIKVKVVGDLI"
     gene            complement(1582..2124)
                     /locus_tag="KR257_003691"
     CDS             complement(1582..2124)
                     /locus_tag="KR257_003691"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889655.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1697 domain-containing protein"
                     /protein_id="HBH0032345.1"
                     /translation="MKSYIALLRGINISGKNKIIMSELKASFVELGYSEVSTYLNSGN
                     VVFLSDVDDSKVISNTIRLMIKKQFELEIPVFIISQEELKDILNNAPNWWGDNNKEIY
                     DNLIFMFPDLSYDEFYDEVGNPKEEYEKVYHYKNAIFWSFSRKDYKKTNWWSKTASSN
                     VSDKITIRTANTVRKIVGMR"
     gene            complement(2272..2556)
                     /locus_tag="KR257_003692"
     CDS             complement(2272..2556)
                     /locus_tag="KR257_003692"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009905562.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcriptional regulator"
                     /protein_id="HBH0032346.1"
                     /translation="MAKNTKQTTVHIDETLLKEVKRIGINENKSISQIINESIIDYIL
                     VYRENEDKEKNEHDKNLNETINEFKKEEEKRMQAKSAARAIAEAKKRVLY"
     gene            complement(2619..3383)
                     /locus_tag="KR257_003693"
     CDS             complement(2619..3383)
                     /locus_tag="KR257_003693"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420423.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="1-acyl-sn-glycerol-3-phosphate acyltransferase"
                     /protein_id="HBH0032347.1"
                     /translation="MNNYLKFATYQLIGFTSSIPRLIKIKKNPDKFSLKEKFEFMQKQ
                     AKKSLDIVNIELNIIGKETLPKEPLLFVVNHSSMLDSFILTASVERPIGCVIADEPVW
                     RNIPIFKEWAKLLRCVYVNRKNNREGIKSIAQASQNILTGQSMAVFPEGDLTWIKEPN
                     SLVSEFRSGALKIAYKAKCPIVPLVIKNSKDTYEGYQPIGKINSVPVEVEFLEPIYDH
                     IENPRLKSSVLGENIKNKMINTIENFRKSNKTFKEF"
     gene            complement(3665..3931)
                     /locus_tag="KR257_003694"
     CDS             complement(3665..3931)
                     /locus_tag="KR257_003694"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889660.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3795 domain-containing protein"
                     /protein_id="HBH0032348.1"
                     /translation="MIESRCGILCYECGYKEKVNCKGCTEIEKPFWGEQCPVKSCCED
                     KNLTHCGLCDTFPCEMLNQFAYDKEQGDDGKRISQCKKWAVLAL"
     gene            complement(3973..4728)
                     /locus_tag="KR257_003695"
     CDS             complement(3973..4728)
                     /locus_tag="KR257_003695"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454427.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HBH0032349.1"
                     /translation="MPHKLLRQYIAHYTISIPDTSIKENLTLIPDASGCMIFKFDKKG
                     IESAFWGATTKTTIVKNDIENVLFRVFVEFRPGGVYYLTGLSQRESTDLKISLEDFNT
                     LFSLEVNSIFERTSTIEELVEQLDMLFLSYLLKSNIVDMTIPILENARKQNSIMSVKN
                     ISQISCYSERHLNRIFNNSLGMSVKSYLRLLRINLVLQEIQNNKIPFATLAQDIGYYD
                     QSHFINDFKSICGVNPTTYIKNLSDFYNEKYKF"
BASE COUNT         1639 a          660 c          675 g         1804 t
ORIGIN      
        1 aagaacttaa atataagaga atggatttgt cctagttgta atgaaactca cgatagagat
       61 ataaatgcaa gtataaatat attaaaagaa ggattaagac taataacaat tcaaaataaa
      121 taacgtatgt aagaaccgga ggaactacgg ggatagcctg tggagaatta gtaagacata
      181 ttttagtatg caaaattctg tgaagcagga accctgtgac tttagtcatg ggaggttcag
      241 ggtagaaaga taaatgaact ttgtaaagat gaagttgtag agttttgcaa tagaataaaa
      301 ggtaaagtgg aaagtgttgc aataagtgga gtatttgctc cagtaaataa acaacaagaa
      361 gaagaagttg caaaatgggt tagagaaatt ttaggggata ttcctatatc tttatcaaat
      421 gaaataggta atataggtat attagaaaga gaaaatggag ctattttaaa ttctgcattg
      481 tctcaagtag gtaaagctgt atctttagga tttgaaaaag cacttaaaga cttaggtata
      541 gatgctcaaa tatatttcag tcaaaatgat ggaacattaa tgaatttaga gtatacaatg
      601 aaatacccaa tttttacaat tggatgtgga ataacaaatt ctataagagg agcttccttc
      661 ttatcaaaag taaaaaatgc aatagtatta gatgttggtg gaactacaag cgacttgggt
      721 gtactatata atggattccc tagagaatca tctattccag ttacaattgg aggagtacat
      781 acaaacttta gaatgccaga tgttttaact attggtcttg ctggtggtac atgtgtaaaa
      841 ggcgaaaaag ataatataaa gataggtcct gaaagtgtgg gatatagaat aactgaagat
      901 gcaataatat ttggtggaga cactctaact ttatcagatg ttgttacaaa attagatatg
      961 gcgtttgaag atagaaaaag caatgttgaa aacttagata aagagtattg taatgaggta
     1021 tataagaagg ttattttaaa attagaagat gctgtagacc aaatgaagac tagtcaagat
     1081 gatgttgaat tggttttaac tggtggagga agtataattg ttcctgaaaa actaaaaggc
     1141 ataagcaatg ttataagacc tcctcattat actgctgcaa atgctattgg tgcagcttta
     1201 ggacaaataa gtggagatgt agaaaaagta tacagtttag ataaaatgtc gagagaagat
     1261 gccatagaag atgcaaaaaa agaggctgta aataaagctc taaaagctgg tgctaaagaa
     1321 gatactatag aagtattaaa tatagaagat gttccacttg cataccttcc tggtaatgca
     1381 cttcttataa aagtaaaagt tgttggtgat ttaatttaaa gaataaatat aagtatttcc
     1441 agaattatat aaatatttct ggactcattt ttaaacttat tttatcaata aaaacagcat
     1501 aacttttgac tatattctta taagtttccg aacagccgat atatacctat tttttgaggt
     1561 ttatcggctg tttgttatct tttatcgcat tccaactatt tttcttaccg tatttgctgt
     1621 acgaattgta atcttatcac ttacatttga actggcagtc tttgaccacc aatttgtctt
     1681 tttataatct ttacgactaa aagaccaaaa gatagcattt ttataatgat atactttttc
     1741 atactcttct ttaggatttc caacctcatc ataaaactcg tcataagata agtcaggaaa
     1801 cataaaaata agattatcat atatttcttt gttgttatct ccccaccaat taggagcatt
     1861 atttagtata tcttttaact cttcttgtga aataataaaa actggtattt ccaattcaaa
     1921 ctgttttttt atcattaatc ttattgtatt tgagataacc ttgctgtcat ctacatcact
     1981 taaaaagaca acattaccac tattaaggta tgtagaaact tctgaataac caagttctac
     2041 aaagcttgct tttaattcag acataattat cttgttctta ccacttatat tgatacctct
     2101 taataatgcg atataacttt tcatataata atttcacctc taaacattca catttttcta
     2161 tgtagtacaa actggaattt gcatctttta taattctttc aaaacttctt catatgtaat
     2221 ttttttaata taaaaaaatc ggtgcttaat ttgtaccgat ttttgttttt cttagtaaag
     2281 aactcgtttt tttgcttctg ctatagctct agcagcactt tttgcttgca ttcttttttc
     2341 ttcttctttt ttaaattcat ttattgtttc atttagattc ttatcatgtt catttttttc
     2401 tttatcttcg ttttctctgt atactaatat ataatctatt attgattcgt ttattatttg
     2461 agatatactt ttattttcat taattcctat tctcttaact tccttaagta gagtctcatc
     2521 aatatgaacc gttgtttgct ttgtattttt tgccacctta atcacctctt aaaaaaaatt
     2581 ctaacattaa aatttttttt agtcaataaa ttttaatatt aaaattcttt aaatgtttta
     2641 tttgattttc taaaattttc tattgtattt atcatcttat tttttatatt ttcacctagt
     2701 acagaagact ttagtctagg attttcgata tggtcataaa ttggttctaa aaattcgact
     2761 tcgacaggaa cagagttaat tttaccaata ggttggtatc cttcataagt atcttttgaa
     2821 ttttttatta ctagtggaac aatagggcat tttgctttat atgctatctt taaagctcca
     2881 cttctaaact ccgaaaccaa tgaatttggt tctttaatcc atgttaaatc tccttctgga
     2941 aacactgcca tactttgacc tgtaagtata ttttgagagg cttgggctat actctttata
     3001 ccctcacgat tgttttttct gtttacatat acacatctta gtaattttgc ccattcttta
     3061 aatataggta tatttctcca aactggttca tctgcaatta cacatccaat tggtctttct
     3121 acacttgctg ttagtatgaa gctgtcaagc atactagaat gatttacaac aaatagaagt
     3181 ggttcttttg gcagtgtttc cttaccaatt atattaagct ctatgttcac tatatctaaa
     3241 gattttttag cttgtttttg cataaattca aatttttcct ttaagctaaa tttatcagga
     3301 ttctttttaa ttttaataag cctaggtata gaagatgtaa aacctataag ttgatatgta
     3361 gcaaatttta agtaattatt cataaaatta tctccttaaa ataaaattat ttattactgt
     3421 aaagatttta acataaaata aaatttaagt ctattttaat tcaattttgt aacatatatt
     3481 ttaaatagac agagattgag attttatatt tccaatttta gtaatcagat tttatcaata
     3541 aattactatt ctattaattt aattaaataa cctttaaatt taattataaa aactgttgca
     3601 gaaatttcta caacagttta aaaaatttac cttacaaaaa cttattttat aacaagagag
     3661 tatattataa ggctagtaca gcccattttt tgcactgaga aattcttttg ccatcatcac
     3721 cttgttcttt gtcatatgca aattgattaa gcatttcaca tggaaatgta tcacatagac
     3781 cacaatgtgt aaggttttta tcttcacaac aagattttac aggacattgt tcaccccaaa
     3841 atggtttctc aatctctgta caacctttac aattgacttt ttccttgtat ccacattcat
     3901 aacataaaat tccacatctt gattctatca ttttaagtca ctccttaaat ataaatttta
     3961 tatgattgta tatcaaaatt tatacttttc attgtaaaaa tcggacaaat tttttatata
     4021 ggttgttgga ttaacaccac aaatagattt aaaatcattt ataaaatgag attggtcgta
     4081 ataaccaata tcttgtgcta aagttgcaaa tggtatttta ttattttgta tttcttgtaa
     4141 tacaaggttt atacgaagta atctaaggta tgatttaaca ctcataccaa gagaattatt
     4201 aaaaattcta tttaaatgtc gttcactata acaactaatt tgtgaaatgt ttttaacaga
     4261 cataatagag ttttgttttc tagcattttc aagaattggt atagtcatat ctactatatt
     4321 tgatttcaat aagtatgata agaataacat atctaattgt tctactaatt cttctatagt
     4381 acttgttctt tcaaaaatgg aattaacctc taagctaaat aatgtgttaa aatcttcaag
     4441 tgaaattttt aaatctgtag attctctttg agaaagacct gtcaaataat atactccacc
     4501 tgggcgaaac tcaacgaata ctctaaaaag tacattttct atatcatttt ttacaatagt
     4561 agtttttgtt gtggctcccc agaatgcgct ttctatacct tttttgtcaa atttaaatat
     4621 catacatcca ctagcatcag gtattaatgt aagattttct ttaatacttg tatctggaat
     4681 agatattgta tagtgtgcta tatactgtct taacaattta tgtggcaaaa tatatgtata
     4741 ctgtttgcag gtatttaaaa tgttattgat tattttat
//
LOCUS       DAEPID010000149         4636 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.152, whole genome shotgun sequence.
ACCESSION   DAEPID010000149 DAEPID010000000
VERSION     DAEPID010000149.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 4636)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4636)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4636
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.152"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            complement(400..4125)
                     /gene="cbpA"
                     /locus_tag="KR257_003696"
     CDS             complement(400..4125)
                     /gene="cbpA"
                     /locus_tag="KR257_003696"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861847.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="collagen-binding adhesin CbpA"
                     /protein_id="HBH0032350.1"
                     /translation="MQQKCKKKALSMILSISMGLGSVASFNASNTFADTIEESTNAGN
                     AEGDTNAGNAEGDTNAGNAEGDTNAGNAGGDANAGNAGGDANAGNAGGDANAGNAGGD
                     ANAGNAGGDANAGNAEEDSNAGNAEGDANAGNAEEDANAGNAEEDSNAGNAEEDMNAL
                     VVEEATAEDPTSVGDFKISGGEINVDFKFASGVLTILSGKQMTIQNNNPNTPTTHRIV
                     IPKDVKAELIFDGVNIKTASNSPFTLTPDKDGGAYAHVILQDGSENKLESGDVYYPGM
                     RAGKGTTLTIDDSVVNRDIEGEFIVPEGGKIPRDVTLENGDKLKKGDRLTLLDSNNRG
                     SLKVVGNYYSAGIGGGNTESGGNIIINGGAITAIGQESSRNTGYGAGIGGGGNGSGGD
                     ITINGGTITAKGAYHGAGIGGGYYTTTKNALSPSVVDPSTGSGYSGNITINGGLSYSY
                     GGAHGSAFGDGCVNPGTNRGYRILVTGGTILPYMTGVGDWIFDLSATTGDVIVTGGSL
                     KATTFKSLGGAVAYGDLEKKTKVFMNKISLKYLGQDKVSTTLVDDFKMLIDGKIYPYG
                     APSYTDDQGVLYLWFSDQFKGSEVSVNLVVIDKITGGNIKPDDFYVKDIGSGSQFLKQ
                     YEEFTIDDTPPYLIIKRYDGLPFEEDVEKLFLDWILKDGGIPIITPKGEKLTDKKFMT
                     ISSQRLNEETMEPDTNLGSDDLTKQVDAGKYQLSITSTQFSNVYPFNEAYWGHRAYYK
                     AEIIPADTETSLVVEESKAKTDVFKPTDTFTLNVTISPDKKEGPDCASPRGYVQFYIN
                     GKEYKDPVELKTHNKGSESHNYSTASIEWRPLDSNHHIFTTEQTITVKYIGDDINYIE
                     GSEDEKKLKLDMTNVDVDGDGIPDINIDTDGDGRPDINIDTSGDWKPDINIDTDNTGE
                     WKPSTEGGNGDGIWKPDKNIDTNGDGNPDTDYNRPAIDTDNDGVDDYWKPDKNVDTGS
                     GGYDTGNPNLNKPDPDNGGNSKPDPDNGGNSKPDSGNGGNSKPDSGNGGNSKPDSGNG
                     GNSKPDSGNGGNSKPDPDNGGNSKPDPDNGGNGKPDPDNGGNSKPDPDNGGNSKPDPD
                     NGGNSKPDIDTDGDGKPNINIDIDGDGKPDINIDTDGDGKPDINIDIDGDGKPDINID
                     IDGDGKPDINIDIDGDGKPDINIDTDGDGKPDINIDTDGNGKPDINIDTDESLDSNVG
                     QNVQTGDQSNIMLDLALMFISLFFLIKNLTNKYLRRK"
BASE COUNT         1357 a          977 c          496 g         1806 t
ORIGIN      
        1 atcacctaat agaatctatg attttttaac ataacctcca taaattagta ccaattatca
       61 cttcaaattc aaatttttat ctgaagaata tacaatcata tttccatact caacataata
      121 ttgagtgttt ggcttgtatt tacaaattat tattctaaca aaaacaacta tacatagatt
      181 aaaatcacct tctaaacata attattaaaa tttaattaat gatatcaatt ccattaatct
      241 cttttaataa aaaattctct tttctatatg aaaattattt caaaactttt aagttaaata
      301 caaaaatgac tataaataga tttttattta cacaaatcta tttatagtca ctatagttta
      361 tccaataaaa taataaaata aatatgtaca caataaatgt tatttacgtc ttaagtattt
      421 atttgttaga tttttaatta aaaaaaacaa gctaatgaac attaatgcta aatctagcat
      481 tatattactt tgatctcctg tttgtacatt ttgacctaca ttactatcta aactttcatc
      541 tgtatctata tttatatctg gttttccatt cccatctgta tctatattta tatccggctt
      601 tccatcccca tctgtatcta tatttatatc cggttttcca tctccatcta tatctatatt
      661 tatatctggt tttccatctc catctatatc tatatttata tctggttttc catctccatc
      721 tatatctata tttatatctg gttttccatc tccatctgta tctatattta tatctggttt
      781 tccatctcca tctatatcta tatttatatt cggttttcca tccccatctg tatctatatc
      841 tggtttgcta tttcctccat tatctgggtc tggtttacta tttccaccgt tatctggatc
      901 cggtttgcta tttcctccat tatctggatc tggtttacca ttgccaccgt tatctggatc
      961 tggtttgcta tttcctccgt tatctggatc cggtttgcta tttcctccat tacctgaatc
     1021 cggtttgcta tttcctccat tacctgaatc tggtttgcta tttcctccat tacctgaatc
     1081 cggtttgcta tttcctccat tacctgaatc tggtttgcta tttcctccat tatctggatc
     1141 cggcttgcta tttcctccat tatctggatc tggcttattt agatttggat tacctgtatc
     1201 ataacctcct gagccagtat ctacattttt atcaggcttc caataatcat ctactccatc
     1261 attatctgta tctattgctg gacgattata atctgtatca gggtttccat ctccattggt
     1321 atctatattt ttatcaggtt tccaaatacc atctccattt ccaccttctg tactaggctt
     1381 ccattcacct gtattatcag tatctatgtt aatatctggc ttccaatcac cactcgtatc
     1441 tatattgata tctggccttc catcaccatc agtgtctata tttatatccg gtattccatc
     1501 cccatctaca tctacatttg tcatatctaa ctttaacttc ttttcatcct cactaccttc
     1561 aatgtaattt atatcatctc caatatattt tacagtaata gtttgttcag tagtaaaaat
     1621 atgatgattg ctatctaaag gtctccattc aatagatgca gtactataat tatgactctc
     1681 actaccctta ttatgagttt ttaattctac tggatcttta tattcctttc cattaatata
     1741 gaattgtacg taacctcttg gagaggcaca atctggtcct tctttcttat ctggtgaaat
     1801 agtaacattt aatgtaaacg tatctgttgg tttaaaaaca tcagttttag ctttagactc
     1861 ttctacaact aatgaagttt ctgtatcagc aggaataatt tctgccttat aatatgctct
     1921 atgcccccaa taagcttcat taaaaggata tacatttgaa aactgtgttg atgtaatgct
     1981 taattgatat tttccagcat caacttgctt tgtaaggtca tcacttccta aatttgtatc
     2041 tggttccatt gtttcctcat ttaaacgttg agaactaata gtcataaatt ttttatctgt
     2101 gagtttttca cctttaggag taattattgg aataccccca tcttttaata tccaatctaa
     2161 aaataatttt tctacatctt cttcaaatgg taatccatca tatcttttaa taatcaaata
     2221 tggtggagta tcatcaatag taaattcttc atattgcttt aaaaattgag aacctgaacc
     2281 tatatcttta acataaaaat catctggttt tatatttcct ccagtaattt tatctataac
     2341 aactaaatta acagatactt cagatccctt aaattgatca gaaaaccata agtaaagaac
     2401 cccttgatca tctgtataac taggtgctcc ataaggataa atttttccat caattagcat
     2461 tttaaaatca tcaactaatg tagtactaac tttatcttgt cctaaatact ttaaagatat
     2521 tttattcata aaaacttttg ttttcttttc taaatcaccg tatgcaactg ctccacctaa
     2581 acttttgaat gttgttgctt ttaatgaacc acctgttact ataacatctc ctgttgtagc
     2641 acttaggtca aaaatccaat ctcccactcc tgtcatataa ggtaaaatcg ttcctccagt
     2701 tacaagtata cgatatcctc tatttgttcc tggattaaca catccatccc caaatgcact
     2761 accatgtgca cctccatatg aataggaaag tccaccatta attgtaatat ttccactata
     2821 accagaacct gtgctaggat ctactactga gggacttaat gcattctttg ttgttgtata
     2881 gtatcctcca cctattccag ctccatggta tgcaccttta gcagttatag taccaccatt
     2941 gattgtgata tctccaccac taccattacc gcctccacct attccagctc catatcctgt
     3001 attacgactc gattcttgac ctatagcagt tatagcacca ccattaataa taatatttcc
     3061 tccactttca gtatttccac cgccaatacc tgcagaataa taatttccaa caacttttaa
     3121 acttcctcta ttattactat ctagtagtgt aaggcgatct ccttttttta acttgtctcc
     3181 attttctaga gttacatctc taggaatttt tccaccctca ggaactataa actctccttc
     3241 aatatctcta tttacaacag aatcatcaat agttagagta gtaccttttc ctgctctcat
     3301 acctggataa tatacatcac ctgactctag cttgttttca ctaccatctt gtaatataac
     3361 atgtgcatat gcaccaccat ctttatctgg tgttaaagta aatgggctat tagatgcagt
     3421 tttaatattt actccatcaa atattaattc agcttttaca tctttaggta taacaatcct
     3481 atgtgttgtt ggagtatttg gattattatt ttgaattgtc atttgttttc cactaagaat
     3541 agttaaaacg ccacttgcaa atttaaaatc gacatttatt tctccaccac taattttaaa
     3601 gtctcctaca gatgtaggat cttctgcagt ggcttcttcc acaactaatg cattcatatc
     3661 ttcttctgca tttcctgcat tagaatcttc ttctgcattt cctgcattag catcttcttc
     3721 tgcatttcct gcattagcat ctccttctgc atttcctgca ttagaatctt cttctgcatt
     3781 tcctgcatta gcatcccctc ctgcatttcc tgcattagca tcccctcctg catttcctgc
     3841 attagcatcc cctcctgcat ttcctgcatt agcatcccct cctgcatttc ctgcattagc
     3901 atcccctcct gcatttcctg cattagtatc tccttctgca tttcctgcat tagtatctcc
     3961 ttctgcattt cctgcattag tatctccttc tgcatttcct gcattagtac tttcttctat
     4021 agtatctgcg aaagtatttg acgcattaaa tgatgctact gatccaagtc ccattgagat
     4081 acttaaaatc attgatagtg ctttcttttt acatttttgt tgcataaatt ccccctcccc
     4141 ttaataattt ttaatataca ctgtatacat ccttatatac actctaataa ttcttaatat
     4201 acactgtata catccttata tgcactctaa taatttttaa tatatactta aaacttatat
     4261 ttgtcaatga atatactgtt tttttcaacc ttatatatta taagtattca ttatttgcta
     4321 aataactaca ataaaaattt taattatata aaatttattt aattttttat ataataatac
     4381 taaggggtaa ttaattgaaa aactagtaaa aatattaata aatattattt gcattattgc
     4441 gctaactttc tctagccttt cgatttacat aaaattatct gaatataaaa aagctgatga
     4501 agtatatacg gaactcagag aaaacactat caataatagc aaacatcaag aactttatga
     4561 taaaaataat gattatagat tctggcttaa aataaacaac gtaaatataa actatcctgt
     4621 agtacaagga tataac
//
LOCUS       DAEPID010000150         4509 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.153, whole genome shotgun sequence.
ACCESSION   DAEPID010000150 DAEPID010000000
VERSION     DAEPID010000150.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 4509)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4509)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4509
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.153"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            174..986
                     /gene="modA"
                     /locus_tag="KR257_003697"
     CDS             174..986
                     /gene="modA"
                     /locus_tag="KR257_003697"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423147.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="molybdate ABC transporter substrate-binding
                     protein"
                     /protein_id="HBH0032351.1"
                     /translation="MFKKLSVLALAMIISLSITACNSKENKANDESNTKVTTADDSKE
                     KETLFVYSGAGLKKPMDEIAKKFEKENNVKVEYSYAGSAQLIAQIETSHKGDVFIVGS
                     EPIYSKAFEKELVGEHKTVAHHTPAIVVPKGNPANIQKLEDLNKDGVKLILGDKESNA
                     IGKTTQKILEKNNLKSINDNVVSTAATVNEMIVQLTSSKADATIATKDSVFGNEDVEV
                     IEIAQDKNIDQLISAGIVNYSDKKDLANKFINYIESDEAKQIFKKYGFEPVK"
     gene            996..1787
                     /locus_tag="KR257_003698"
     CDS             996..1787
                     /locus_tag="KR257_003698"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861521.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBH0032352.1"
                     /translation="MKNKFFTTLLTGFFAIVFLFIVSPLLMLIIKGISYVPICLKSVE
                     VQYAITLSIKTSLISTIVCLLLAIPVAYFLHITKLPFKKLIIQIINLPMSLPHLVSGI
                     ALLLLFGRMGIGDSIYKIFKLDFIFTKQGIVLAQIFVNLPLTIKILHTSLNESNEKMI
                     FVARTLGCNSWEAFRFIILPNLKTGIISATVMTWSRALGEFGAVAMIAGSTRMKTEII
                     PTSIYLNMSTGDIDIAIGIAVILIFLSLTCLMLFEIFFNREVDKN"
     gene            1789..2484
                     /locus_tag="KR257_003699"
     CDS             1789..2484
                     /locus_tag="KR257_003699"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893573.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="HBH0032353.1"
                     /translation="MLKIKNLSLDLPNFKLQENSLNINNHEYFVLLGASGSGKTLFLE
                     TLAGRYPSAKGNVSYKENLISNLPPENRNIGFVYQNFELFPNMNVEDNIRFPLKLRKI
                     PIDEQILKANHLSKLMQIEDIKNRYPKNLSGGEKQRVAFARALIAEPDILLLDEPMSS
                     LDYITKKHISKILKDVYIKYKPTVIHVTHDISEAMFFAHKIGIMNNGKINHIFDLNEE
                     IKNKGESFFYEYI"
     gene            2471..3202
                     /locus_tag="KR257_003700"
     CDS             2471..3202
                     /locus_tag="KR257_003700"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423141.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0032354.1"
                     /translation="MNIFDILRDYLLVQVDKYNLNMDMISIVSKSLSSKEAIGNTKRK
                     DFPIIVGKEIMLEADFKGAKGQAFTSTPSTFEGSLKDILSLDLHDNSHDRSLFIASLN
                     AVMKYLGKTDRTIHCKNNEPEVCAKKFPEFIKMEFGNPKVAIIGYQPAIIDNIKDFFE
                     TRVLDLNPEFVDTIQYNVKIEDGIRDYEDVISWADLVICTGSTLCNNSIINFLSLNKP
                     VYYYGTTIAGASNILGLKRLCFCSK"
     gene            3516..4316
                     /locus_tag="KR257_003701"
     CDS             3516..4316
                     /locus_tag="KR257_003701"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423139.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PIG-L family deacetylase"
                     /protein_id="HBH0032355.1"
                     /translation="MTFKNKKFTINKYKILSIILVLCLILTAFSSYVNYSHKKFKDYV
                     VFYVQHQDDEVLWAGSAIVNAIKERGKNHVFVVLVSTGCGISVFDKYKKYENLTNIQK
                     SEYRNREFLASLNSLGVIRENIILLPETNTNGNTDFNYMEKIALTFEEKFKNVTHIAH
                     TYKLDDHLQHLKNGSVIQNLYNAGKIKDAKYFVKPKFADKITFNNKIVYKAHSTEDYE
                     KVKNACQQYKIVDELEYREGIGYKSDHKSFDKLLNNKDVPAILHTPNL"
BASE COUNT         1764 a          563 c          642 g         1540 t
ORIGIN      
        1 attaaaaata aaataactac ctatggaaat gacattatga atagattttt tcttaactat
       61 acataacaaa acataacaaa acattataaa acataacaaa aacttagaca tcgttttctt
      121 agtatgatat actaaaaaag aatttacact aatttaataa gggggaatat cttatgttta
      181 aaaaactttc agtactagct ttagctatga ttatttcatt aagtattact gcatgtaatt
      241 ctaaagaaaa caaagctaat gatgaatcta atactaaagt gacaacagct gatgattcaa
      301 aagaaaaaga gactcttttt gtctattcag gggcaggttt aaagaaacca atggatgaaa
      361 tagcaaaaaa atttgagaaa gaaaataatg tcaaagttga atatagctat gcaggttctg
      421 cacagctaat agctcaaatt gagacaagtc acaaaggaga cgtatttatt gttggttctg
      481 aaccaattta ttcaaaggcc tttgaaaaag aacttgtagg tgaacataaa acggttgcac
      541 atcatacacc tgcaatagtt gtacctaaag gaaatccagc taatattcaa aaattggaag
      601 acttaaataa agatggagtt aaacttattt tgggagacaa agagtctaat gctataggta
      661 agactacaca aaaaatactt gaaaaaaata atttaaaatc tataaatgat aatgttgtct
      721 ctacagctgc aactgtaaat gaaatgattg tacagttaac atcaagtaaa gctgatgcta
      781 caatagccac aaaagattcg gtctttggta atgaagatgt agaagttata gaaattgccc
      841 aagataaaaa tatagaccaa ctcatatcag caggaatcgt aaactatagt gataaaaaag
      901 atttagctaa taaatttata aattatatag agtcagacga agctaaacag atatttaaaa
      961 aatatggttt tgaacctgtt aagtagtgat taaacttgaa aaataaattt tttactactc
     1021 tacttactgg attttttgct atagtctttt tgtttattgt atcaccactt cttatgttaa
     1081 tcattaaagg gataagttat gttcctatat gcttaaaatc agtggaagta cagtatgcaa
     1141 taacacttag tattaaaaca tctttaatat ctactatagt atgcctttta ttagctattc
     1201 cagtagcata ttttttacat attactaaat taccatttaa aaaactgatt atacagataa
     1261 taaatctccc tatgtctctt ccacacttag tatcaggaat tgctctttta cttttgtttg
     1321 gaagaatggg gattggagat tccatttata agatttttaa gcttgatttt atatttacaa
     1381 agcaaggtat agttttagca caaatatttg taaatcttcc acttactatt aaaatacttc
     1441 acacttcatt aaatgaaagt aatgaaaaga tgatatttgt tgcacgtacc cttggatgta
     1501 atagttggga agcatttaga tttataattc ttccaaatct aaaaactgga atcatatctg
     1561 caactgtaat gacttggtca agagcacttg gtgaatttgg tgcagtagct atgatagcag
     1621 gttctacacg tatgaaaact gaaattattc ctacatctat atatttaaat atgtctactg
     1681 gtgatataga cattgctatc ggaatagctg taattttgat atttctctca cttacatgct
     1741 tgatgctttt tgagatattt tttaatagag aggttgataa gaattaatat gttaaaaata
     1801 aaaaatttat ctcttgattt acctaatttt aaattacaag aaaatagttt aaatattaat
     1861 aatcatgaat actttgtttt attaggagct agtgggtcag gtaaaactct atttctagaa
     1921 acattagcag gaagatatcc atctgctaaa ggaaatgtat catacaaaga aaatttaata
     1981 tcaaacttac ctccagaaaa tagaaatata ggatttgtat atcaaaattt tgaattattt
     2041 ccaaatatga atgttgaaga taatataagg tttccactta aattgagaaa aatacctata
     2101 gatgaacaga ttcttaaggc taaccacttg tctaaattaa tgcagataga agatataaaa
     2161 aataggtatc ctaaaaattt aagtggaggc gaaaagcaac gagttgcttt tgcacgtgcc
     2221 ttaatagctg aacctgatat attactttta gatgaaccta tgagttcatt ggattatatt
     2281 acaaaaaaac atataagcaa aattttgaag gatgtctaca taaaatacaa accaacagtg
     2341 attcatgtta ctcatgatat ttctgaagca atgttttttg ctcataagat aggaataatg
     2401 aacaatggaa aaataaatca tatttttgat ttaaatgaag aaataaaaaa taaaggagaa
     2461 tcttttttct atgaatatat ttgatatttt gagagattat ctattagtac aagtcgataa
     2521 atataattta aatatggata tgataagtat tgtgtccaaa tctctatctt caaaagaagc
     2581 aattggaaat actaagcgta aagatttccc aattatagtt ggtaaagaaa taatgcttga
     2641 agctgacttt aaaggagcta aaggacaagc atttacttct actccatcta catttgaagg
     2701 ttctttaaaa gacatattat cattagattt acatgacaat tctcatgata gaagtctttt
     2761 tatagcatca ttaaatgcag ttatgaaata cttaggcaag acggatagaa ccattcattg
     2821 taaaaataac gagccagagg tatgtgcaaa aaaattccct gagtttataa aaatggaatt
     2881 tggtaatcca aaagtagcaa ttataggata tcaaccagcc ataattgata atattaagga
     2941 ctttttcgaa acaagagtat tagatttaaa tcctgaattt gtggatacta ttcaatataa
     3001 tgttaagatt gaagatggta tacgagatta tgaagatgta atatcttggg ctgatttagt
     3061 gatttgcaca ggaagtacat tatgtaataa ctcaattata aattttctat cacttaacaa
     3121 accagtttac tattatggaa ctacgatagc tggtgcatca aatattttag gtttaaaaag
     3181 actctgtttt tgtagtaaat aagcaatcat atcatcaagg agtacacaaa tatatatgtg
     3241 tactctttaa atttaaaaag ttattacttt tattctaagt actaaagtaa aattctatta
     3301 aaatgaatcc cgaataaatg tacaatccct ttaaatctca attcctatca atcattaata
     3361 ttttgattag tcttatacat aaatgttttc tttattttaa actaataaaa aaattttatt
     3421 ccattaatct actctatatt tttcagcatt taagaaataa tttttagtac tttgtttgat
     3481 aatataacta agacaacctt tcaggagatg attaaatgac atttaagaat aaaaaattta
     3541 ctataaataa atataaaatt ctatctatta ttctagtttt atgtttgatt ttaaccgctt
     3601 ttagtagcta tgtgaattat agtcataaaa aatttaaaga ttatgttgtc ttctatgttc
     3661 agcatcaaga tgatgaagtg ttgtgggctg ggagtgctat tgttaatgct ataaaagaaa
     3721 gaggaaaaaa tcatgtattt gtggttttag tatctactgg atgtggtata tccgtctttg
     3781 ataaatataa aaaatatgaa aacctaacaa atatacaaaa atcagaatat agaaatagag
     3841 aatttttagc ttctcttaat agccttggtg taataaggga aaatataata ttattaccag
     3901 aaacaaatac aaatggtaat actgacttca attacatgga aaaaattgct cttacatttg
     3961 aagaaaaatt taaaaatgta actcatatag cacatactta taaattagat gaccatttac
     4021 aacatttaaa aaatggttct gttatccaaa atttatataa tgctggtaaa ataaaagatg
     4081 ctaaatattt tgtaaaacct aaatttgctg ataaaataac ttttaataat aagatagttt
     4141 ataaagctca ttctactgag gactatgaaa aggttaaaaa tgcctgtcaa caatacaaaa
     4201 ttgttgatga attagaatat agagaaggta ttggctataa gtctgaccat aaatcatttg
     4261 ataagttatt aaataataaa gatgttcctg ctatacttca tacacctaat ttataagaaa
     4321 tatttattct ttaatttaag ttataaaaag gaaattattt gagattttgt gatatagcac
     4381 tttttgtgct atactacttt ttctcataca actattaccc atatctaatt tcatcatctc
     4441 ttaaaatata taaagatatc atcattaaaa cctataagcc ttattaaatg ctttatacat
     4501 acctacatt
//
LOCUS       DAEPID010000151         4370 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.154, whole genome shotgun sequence.
ACCESSION   DAEPID010000151 DAEPID010000000
VERSION     DAEPID010000151.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 4370)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4370)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4370
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.154"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            231..1310
                     /locus_tag="KR257_003702"
     CDS             231..1310
                     /locus_tag="KR257_003702"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895654.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA alkylation repair protein"
                     /protein_id="HBH0032356.1"
                     /translation="MPELLKNMYNRESLYEVAVAIQSVYNSFKVDEFIKSTMDETWNN
                     LELKARCRKISMSLGMYLPEDYKEALSILEKSVTGFYFAFFFPDFVEVYGQDDINWDL
                     SISALERNTEYWSSEFAVRAFIIKDEERMMAQMRKWSKHKSEHVRRLASEGCRPQLPW
                     GQAISKFKKDPTPVLPILEQLKTDTSTYVQKSVANNLNDISKTHPDLVISIAKDWYGK
                     NKSTNWIVKHGCRTLLKKGNRDVLALFGYDDTTSINLQDFTLETTSISIGEDLTFSFN
                     ILAKKATKTRLEYGIDYIKSNGKRNRKIFKISEVSLKENEKKSYMKKHSFADVSVRKH
                     YPGIHSIAIIINGIEKDKLDFELGI"
     gene            1634..2002
                     /locus_tag="KR257_003703"
     CDS             1634..2002
                     /locus_tag="KR257_003703"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728895.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nuclear transport factor 2 family protein"
                     /protein_id="HBH0032357.1"
                     /translation="MDVYSFWNDTLAQDAVKIRKYFHENAYINWHDTNEHFTLEEFII
                     ANCEYPDKWNGKVEKVLEFGNLVITVTHVYAINKPLSFHVVSFISLKDDKIISIDEYW
                     GEDNDVPQWRLDKHIGKPIK"
     gene            2119..2922
                     /locus_tag="KR257_003704"
     CDS             2119..2922
                     /locus_tag="KR257_003704"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888422.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha/beta hydrolase"
                     /protein_id="HBH0032358.1"
                     /translation="MEEKYILSDRGKVYYWIKESNSVFAKNLIFLPGLTANHHLFDFQ
                     IQYFSKNHNVLVWDAPAHGKSRPYLDFSYSNLVEELKVILDKQNMKKVVLIGQSAGGF
                     VAQSFIVKYPNMVEGLMMIGTCPYGTDYYSKSDIFWLKQTEWMLKLFPDKFLRNIISK
                     MCGATSEGRRSMMKMLEGYEKKELCHLMYLGFAGFIPEIQDLNIHCPVCLVVGDKDKT
                     GKVRKYNEQWHNKTGYPLHIIKNASHNVNVDKPNELNQIMDIFIKQLNI"
     gene            3307..4197
                     /locus_tag="KR257_003705"
     CDS             3307..4197
                     /locus_tag="KR257_003705"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902047.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="radical SAM protein"
                     /protein_id="HBH0032359.1"
                     /translation="MIESIPAKQILQKVKFDNTRWFGIDYNMNLYRGCSHGCIYCDSR
                     STIYNIENFDKVRYKENVIEILSKELRSKRKKGVVGIGAMSDTYNPFEKQLCITKQAL
                     DLISENHFGVSIDTKSSLVVRDIPILQKIKKNNSAIVKLTITTANDELSKKIEPYVNP
                     SSVRFEAVKELNDSGIFCGILLTPMLPFLTDTKDEIRAIVEKAHKANAKFIYCMYGVT
                     MRSGQREFFYEHLRDISPKLVFKYQKTYGLNYVCTVQNKDCCEKLLREECARYGILTD
                     MKDIIKAYKRSESYTQIKFF"
BASE COUNT         1670 a          474 c          818 g         1408 t
ORIGIN      
        1 cagtaaagta taaaattcta ttactataat aaaagataga actagaagtc tttatgaaag
       61 tgggaaaagt atttatataa ataaattcat atagtttata gtttaatagt aggaaatatc
      121 gtatgagtaa gaatattgta ttttacataa agatttagca atatgacaca ctgttgtcgt
      181 gttctgtagg atatgattaa taaatcagat atgaaaggag agtgagtaat atgccagaat
      241 tactaaaaaa tatgtataat cgtgagtcac tttatgaagt tgcagtagct atccaatcag
      301 tttacaactc atttaaggta gacgagttca taaaatctac aatggatgag acatggaata
      361 acttagaatt aaaagccaga tgtcgaaaga taagcatgag tttaggaatg tatttaccag
      421 aagactataa ggaagctctt tccattcttg aaaaatcagt tacaggtttt tattttgctt
      481 ttttctttcc agattttgtt gaagtttatg ggcaggacga cataaattgg gatttatcta
      541 taagtgcatt agaaagaaat actgagtatt ggtcttcaga atttgctgta agagcattta
      601 tcatcaagga tgaagaacgt atgatggcac agatgcgtaa atggtctaag cataagagcg
      661 aacatgtacg aagacttgca agtgaaggtt gtcgtcccca gttgccttgg ggacaagcaa
      721 tatccaaatt taaaaaagac cctacacctg tgctacctat attggagcaa cttaaaacag
      781 atacatcaac gtatgtacaa aagagtgttg ctaataatct aaatgatatc tcaaaaacac
      841 atccagattt agtcataagc attgcaaagg attggtacgg taaaaataaa tctactaact
      901 ggattgtaaa gcatggttgt agaactctac taaaaaaagg aaatcgtgat gtattagccc
      961 tttttggata tgatgatact acttctataa atcttcagga ctttacttta gaaacaacgt
     1021 ctatttctat tggagaggat ttaacttttt catttaatat tttagcaaaa aaagcgacaa
     1081 aaacaaggct cgagtacgga attgattata ttaaatctaa tggaaaaagg aataggaaga
     1141 tatttaaaat atcggaggtt tcattaaaag aaaatgagaa aaagtcatat atgaaaaaac
     1201 attcatttgc agatgtaagt gtaaggaaac attatccagg tatacactcg attgctatta
     1261 ttattaatgg tatagaaaaa gataaacttg attttgaatt aggtatataa ttttactaac
     1321 agaataatct atatcagata ctttgctaaa cttatataat atattttact aaatttatat
     1381 taggtagttt actacttgtt tactgaattt aaatacaaag aaatacaggt gctaatccct
     1441 gcccattaaa ggaatatgag cataacacaa aagtagaact tatcaattct gttacgggta
     1501 tagtagtaaa tccatagaat cacaattaga agatgaagtg taaaaaataa gttagtgttg
     1561 attttagttg ctagtgatat tgaatagtta tacaatagct atataaatta gaatttgtag
     1621 aggagaaatg taaatggatg tatatagttt ttggaatgac actttagcac aagatgctgt
     1681 taagataaga aaatattttc atgaaaatgc ttatattaat tggcatgata caaatgagca
     1741 ttttacttta gaagaattta ttattgcaaa ttgtgagtat cctgataaat ggaatggtaa
     1801 agtagaaaag gtgctagaat ttggaaattt agtaattaca gtgacacatg tttatgcaat
     1861 aaataaacca ctatcatttc atgtcgtttc atttatcagc cttaaagatg ataagattat
     1921 ttctattgat gaatattggg gagaggataa tgatgtgcca cagtggagat tagataaaca
     1981 tattggaaag ccaataaaat agtttttgtt ctgttttata actgaaattt tgataacatt
     2041 tgatattttg atttgtcatt ggtcaacata gtcgttagtg taataattta aaaaagtaga
     2101 atttggagag tgaacactat ggaagaaaaa tacatcttat ctgaccgagg gaaagtatat
     2161 tattggataa aagaaagtaa tagtgtgttt gcaaagaact taattttttt gccaggacta
     2221 acagcaaatc atcatctttt tgatttccaa atacagtact tttcaaaaaa tcataatgta
     2281 ttggtatggg acgctcctgc tcatggaaaa tcaagacctt acttagattt ctcatattct
     2341 aacttggtag aagaattgaa agtaatttta gataaacaaa atatgaaaaa ggttgtactt
     2401 atagggcaat cggcaggggg atttgtggca cagtccttta ttgtaaaata tccaaatatg
     2461 gtagaaggac taatgatgat tggaacttgt ccatatggaa ctgactatta tagtaagtca
     2521 gatattttct ggttaaaaca gactgaatgg atgttaaagt tattcccaga taaatttttg
     2581 cgaaacataa tatctaagat gtgtggagct acgtctgaag gcagaaggag tatgatgaaa
     2641 atgttagaag gctacgaaaa aaaagaactg tgtcatctca tgtatctggg atttgctggg
     2701 ttcataccag aaattcaaga cttaaatata cattgtccag tttgtttggt ggttggagat
     2761 aaagacaaga cgggtaaagt gagaaaatat aatgagcagt ggcacaacaa gactgggtat
     2821 ccattgcaca ttataaaaaa tgcttcacat aatgtaaatg tcgataaacc taatgaacta
     2881 aatcagatta tggatatatt tattaagcaa ttaaatatat aaaaattaca tactcattag
     2941 gtaaattatg tagtatatgt gtttatagat ggttatagaa ataaatatgt aataaactac
     3001 ttaacactta aaaagtggat ttgtccagag cataatacaa agcatgatat ataaattttt
     3061 aagcgaaata catcaaaaga agtattagaa ttagtggaga taaaacagct attagagatt
     3121 ataaataaat agttttaaag gtactacgaa tatagaggaa ggtaaatcat acgttattca
     3181 aggattataa atgattagtt taaaagtact atcggacagg tctctgcata tttaaacctt
     3241 agtaaaggta gttaaagtag tagtttaaaa actaaaaaat tatataaagg aattaggtat
     3301 aagaaaatga ttgagagtat accagcaaaa caaattttac aaaaagtgaa atttgacaat
     3361 acaagatggt ttggaattga ctataatatg aatctctatc gtggttgttc tcatggatgt
     3421 atatattgtg atagccgtag cacaatatac aacatagaga attttgacaa agttagatat
     3481 aaagaaaatg tgatagagat tttaagtaaa gaattgcgtt caaaaagaaa aaaaggggta
     3541 gtaggcattg gagctatgtc tgacacatat aatccttttg aaaagcaact ttgtattaca
     3601 aagcaggcac tagatttgat ttcggaaaat cattttggag tgtctattga tactaaaagt
     3661 agtttggtgg ttagagatat accgattttg cagaaaatta aaaaaaataa ttctgctatt
     3721 gtaaagttga ctataaccac tgcaaatgat gaattatcaa agaaaataga accttatgta
     3781 aatccaagtt ctgtacgatt tgaggcagtg aaagaactta atgattctgg aattttttgt
     3841 ggtatattat tgactcctat gcttccattt ttgactgata ctaaagatga aatacgagca
     3901 attgtagaaa aagcacacaa ggctaatgca aaatttattt attgtatgta tggtgtaaca
     3961 atgcgtagtg gtcagcgaga gtttttttat gagcatttaa gagatatatc accaaaattg
     4021 gtatttaaat atcagaaaac atatggttta aactatgtat gtactgtaca aaataaagat
     4081 tgttgtgaga agttgttaag agaagaatgt gcacgttatg gtattttgac ggatatgaaa
     4141 gatattataa aagcgtacaa gaggtcggag tcatatactc aaataaaatt tttttaagat
     4201 aggctttgga tgagatataa tagtggtgat tgatgtgttg atattatagt tgattgttag
     4261 agaggatatt atagatgaat attagtatta atattttagg taattgctag agctgatatt
     4321 atagatgaat attaatattg atattctagg taattgctag agttagtatt
//
LOCUS       DAEPID010000152         4228 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.155, whole genome shotgun sequence.
ACCESSION   DAEPID010000152 DAEPID010000000
VERSION     DAEPID010000152.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 4228)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4228)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4228
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.155"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            163..501
                     /locus_tag="KR257_003706"
     CDS             163..501
                     /locus_tag="KR257_003706"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889960.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3784 domain-containing protein"
                     /protein_id="HBH0032360.1"
                     /translation="MFAVGFVVIIALAFFILSVLLFNGKASMLLAGYNSMSKKEKARY
                     DKKKLCRSSSIVTFIVSIMLFIMAFLGYRIESGQMDEKKMVPFSIIFIIVILSSVFFN
                     ILYSNKKCKK"
     gene            complement(908..2344)
                     /gene="miaB"
                     /locus_tag="KR257_003707"
     CDS             complement(908..2344)
                     /gene="miaB"
                     /locus_tag="KR257_003707"
                     /EC_number="2.8.4.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428816.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA (N6-isopentenyl
                     adenosine(37)-C2)-methylthiotransferase MiaB"
                     /protein_id="HBH0032361.1"
                     /translation="MSKRKQVTIPIEKIQEQDKYIEQIHRQNEEYFNRTGKRKLVFTQ
                     TFGCQMNEHDSEKLCSMLEEMGYQMSMMVEESDLIIYNTCAVRENAELKVYGNLGQLK
                     HLKGKNPDMKIAVCGCMMQQPHVVEELRKKYKHVDLIFGTHNLYKFPQLLTESINSDK
                     MLVDVWDVDGEVIEGLRSNRKFELKAFVNIMYGCNNFCTYCIVPYTRGRERSRTPEDI
                     INEIKELVANGTKEITLLGQNVDSYGKTLENPVSFSELLRKVNDIEGIERVRFMTSHP
                     KDISDEVIYAIRDCDKVCEFLHLPIQCGSSSLLKKMNRHYTKEYYLEIIEKAKKEVPG
                     IAFSTDLMIGFPGETEEDLLDTLDVVEKVRYDSAFTFIYSKRQGTPAAKMENQIPEDI
                     KHDRFNRVLEAVNRISAEINDGYKDRIVEVLVEGRSKNNENKFAGRTRQNKLVNFEGG
                     NDDLIGKLVMVKITEPRTFSLNGILVNN"
     gene            complement(2592..4040)
                     /locus_tag="KR257_003708"
     CDS             complement(2592..4040)
                     /locus_tag="KR257_003708"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897130.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell wall-binding protein Cwp28"
                     /protein_id="HBH0032362.1"
                     /translation="MKFYKRILTLTLSISFVFANIQLVDAISSVEKIQGKNKYEIAGK
                     IADKNAYKTAYKTAILINTSNSIADGLSASGLAGALNAPILLTEKNTIPTETSARLKN
                     VSKVYIIGGTYSISTSVENSLKSKKMKVVRIKGNDRIKTSYNVAKEINSIKKVNTVML
                     TNAYKGEADAISIASVAARDKAPIILTNGQSIPFSTSGLKSYVIGGTASMSTTLVNNT
                     KSTRLGGSTRFETNKAIINKFYKDAREFYIAGAYELTNALVGSSLSKHGPMVLVNDGS
                     NKSILKNAKKITSIGYIDSNIVQQCLNITNGIGDINTGVVKNVKPTTKTIKDGMYKVG
                     KDISAGEYLITSNSGSYASYYEVTSDSTGNADSILSNDIFSGTRYITLKNGQYIKIED
                     STMTLAKYAKAQKAKNGKFGNGMYKIGLEIPAGEYIIMSNSSDAYYEVRNDSLGNAEG
                     IVTNDTFSGRRYITVEEDQYLILNDCYLIENE"
BASE COUNT         1378 a          665 c          451 g         1734 t
ORIGIN      
        1 aatgcaattt caacataaat actatgtatt agtgtatact gttgatgaat taaagtatga
       61 taatctattt aataaagtat gaagtaaatg attttaatgt gcctttatgg taaaattact
      121 aataagtaat aaaattaatt aaaatatatg gaggtgctta taatgtttgc tgtaggattt
      181 gttgttataa ttgcacttgc ctttttcatt ttaagtgtac tattatttaa tggaaaagcc
      241 agtatgctac tagcaggtta taactctatg agtaagaaag aaaaagcacg atacgataaa
      301 aaaaaattat gtagaagttc tagcattgtt acttttattg tctctataat gctatttatt
      361 atggcgtttt tgggatatag aatagagagt ggtcaaatgg acgaaaaaaa aatggttccc
      421 ttttctataa tatttataat agtcatactt tccagtgtat tttttaatat cctctactct
      481 aacaaaaaat gtaaaaaata aatagttgta agttgagcag ttaattataa aagattgact
      541 gctttttcat gtatattgac tactcttatt aaatatttta acatttaaaa atctatgtaa
      601 aaataatgaa tatagtacaa acttctaata atgattttac ctttgtggtt acagtccact
      661 atatataatt taatatgata acagggaatt actaatgaca actaggtaag cttttataaa
      721 atataataaa acaaaaatag atgtacaatg aaattatatc ttatatcaaa tttattttta
      781 ttaatagcaa aaacttacat tagcataaca tatgacaaat tcgcttaaaa taaaaatttt
      841 taatataatt tgttctatag tacatctatt ttgattagtt tacataattt tattattttg
      901 tacaatatta attatttact aatatcccat ttaatgaaaa agttctaggt tcagtaattt
      961 ttaccataac taatttacca attaaatcat catttccacc ttcgaaattt acgagtttat
     1021 tttgtctagt tctaccagca aacttatttt cattattttt acttcttcct tcaactagaa
     1081 cttcaactat tctatcttta tatccatcat ttatttctgc agaaatccta tttacagctt
     1141 ctaacaccct attaaatcta tcatgcttta tatcttctgg tatttgattt tccattttag
     1201 cagcaggagt tccctgtctt ttagaataaa taaatgtaaa agctgaatca tatctaactt
     1261 tttcaaccac atctaaagtg tccaataaat cttcttctgt ttctcctggg aaaccaatca
     1321 ttaagtctgt agaaaaagca atacctggaa cttccttttt agctttttct attatttcta
     1381 aataatattc ctttgtataa tgtctattca tttttttcaa aaggctactg cttccacatt
     1441 gtattggtag atgtaaaaac tcacacacct tatcacaatc tctaattgcg tatattactt
     1501 catcagatat atcttttgga tgagatgtca taaatcgaac cctttcaatt ccttctatat
     1561 cattcacttt tcttaaaagt tctgagaatg aaactggatt ttcaagtgtc ttaccataag
     1621 aatctacatt ttgtccaagt aaagtgattt ctttcgttcc atttgcaaca agctctttta
     1681 tctcgttaat tatatcttca ggagttctac ttctttctct tcctcttgtg tatgggacta
     1741 tacaatatgt gcagaaatta ttgcatccat acattatatt tacaaatgct tttaattcaa
     1801 attttctatt acttctaaga ccttctatta cttctccatc cacatcccat acatccacta
     1861 acattttgtc agaatttatt gattctgtaa gtaattgcgg aaatttatat agattatgtg
     1921 ttccaaatat aaggtctaca tgtttatatt tttttcttaa ttcctctaca acatgtggtt
     1981 gttgcatcat acatccacat acagctattt tcatatctgg attttttcct tttagatgtt
     2041 ttaattgtcc taagttacca tacactttta gctctgcatt ttctctaact gcacaggtgt
     2101 tatatattat taaatcactt tcttcaacca tcattgacat ttggtatccc atctcttcta
     2161 acattgaaca taatttttct gaatcatgtt cattcatttg acacccgaag gtttgagtaa
     2221 acacgagttt tctctttcca gttctgttga agtattcttc attttgtctg tgtatttgtt
     2281 ctatatattt atcttgttct tgtattttct ctataggtat tgttacttgt tttcttttgc
     2341 tcacgtctat tcctcctagt taatttctta tattacacat aaccttaatt atatcaaata
     2401 agaaaaatct tttaaagata ttattatttt tctagttgtg ttttaatagt aaatctaatg
     2461 atttatatat actatatttc taaaatataa aatcatataa ttattataat aataaaaaga
     2521 tgttttaaat taaaacttaa aacacctttc cttaaataaa atatatgatt tactattaaa
     2581 tacaattaca tctattcatt ttcaattaaa taacaatcat ttaatattaa atattgatct
     2641 tcctcaaccg ttatatatct tcttcctgaa aaagtatcat tagtaactat tccctctgca
     2701 ttacctaagc tatcatttct aacttcataa tatgcatcag aagaatttga cattataata
     2761 tattctccag caggaatttc taatccaatt ttatacatac catttccaaa cttaccattc
     2821 ttggccttct gggctttagc atactttgct aatgtcattg ttgaatcctc aattttaata
     2881 tattgaccat tctttaaggt gatatatcta gtcccactaa aaatatcatt tgaaagtata
     2941 ctatcagcat tacctgtact atcacttgta acttcataat aagaagcata acttcctgag
     3001 tttgaagtta ttaagtattc acctgctgag atatcttttc caaccttata cattccatct
     3061 tttatagtct ttgtagtagg tttaacattt tttacaaccc cagtattaat atctccaatt
     3121 ccatttgtta tatttaaaca ctgttgtact atatttgaat ctatatatcc tatagaagtt
     3181 atcttcttag cattttttaa aatgctttta ttgctaccat cgttaactaa aaccattgga
     3241 ccatgttttg ataaagaaga tcctacaagt gcatttgtta attcataagc tccagctata
     3301 taaaactctc tagcatcctt ataaaactta tttattattg ctttattagt ttcaaaacga
     3361 gtactccccc ctagtctagt agatttagta ttgtttacta aagtggtact cattgaagct
     3421 gttcctccta ttacataaga ctttaaacca ctagttgaaa aaggtatact ttgtccatta
     3481 gtaagaatta ttggtgcttt atctcttgct gctacagatg caatacttat agcatctgct
     3541 tctcctttat atgcattggt tagcataaca gtattgactt tttttattga atttatttct
     3601 tttgcaacat tataacttgt ttttattctg tcatttccct taattcttac aactttcatt
     3661 ttcttagatt ttaatgaatt ttcgacagat gtactaatag aatatgttcc tccaattata
     3721 taaacttttg atacattttt taatcttgca gatgtctcag ttggtatagt atttttttca
     3781 gttaatagta taggggcatt taaagctcct gctagtccac ttgcacttaa tccatctgca
     3841 atagagttac tagtattaat taatatagca gttttatatg cagttttata tgcattttta
     3901 tctgctattt tacctgctat ttcatactta ttttttcctt gtattttttc tacagatgat
     3961 attgcatcta ctaattgaat atttgcaaat acaaaagaaa tacttaaagt caatgttaat
     4021 attcttttat agaatttcat aataaaattg tccccctcat aataaatttt taatatataa
     4081 atacatattc ttaaattagt tatgtactta acaaacttat gtaaaattgc aaattatatt
     4141 aagtatatta caaataaata ttaatacaat tattcattta gctataattg tatttacatt
     4201 tatattaaaa atcaactaga tttgtata
//
LOCUS       DAEPID010000153         4182 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.156, whole genome shotgun sequence.
ACCESSION   DAEPID010000153 DAEPID010000000
VERSION     DAEPID010000153.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 4182)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4182)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4182
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.156"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            complement(108..1529)
                     /locus_tag="KR257_003709"
     CDS             complement(108..1529)
                     /locus_tag="KR257_003709"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454919.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="carbon starvation protein A"
                     /protein_id="HBH0032363.1"
                     /translation="MVSFLGSIVVLIVGYFVYGTFVEKVFGTNDKNQTPAIACRDGVD
                     YVPMKWKRIFLIQFLNIAGLGPIFGAIQGALFGPSAFLWIVFGTIFAGGVHDFASGYL
                     SMKNKGTSASELVGLYLGNGAKIAMRIFSVILLVLVGVVFVTGPAGLLKTLTGVNAQI
                     WVGVIILYYIMATVLPIDKLIGKIYPLFGAALLIMAVGVAGGLIIKGYNIPNINLQNM
                     NPNGTPLFPYLFITIACGAISGFHATQSPLMARCVEKESEARPVFYGSMVAEGIIALV
                     WAAAAMSYFHGIPQLNVIFNDGGAATVVNTVSVGLMGPIGGALAILGVVACPITSGDT
                     AFRSARLTIADAMNYNQDAVKNRFLIALPLFAVGVALTFIDFNIIWRYFSWANQTLAM
                     IMLWTGSAYLVKANKNHYITTLPALFMTVVTFSYIMQAKEGFRLPVNISNGIGVIVAI
                     ILGLLFFKKAKHIKEQNNHKLAS"
     gene            complement(1675..2445)
                     /locus_tag="KR257_003710"
     CDS             complement(1675..2445)
                     /locus_tag="KR257_003710"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001295458.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HBH0032364.1"
                     /translation="MRAIIVEDEFPARKELRYFIENKSGIEVVSEFTNGIEVLDFIQE
                     NKIDVIFLDINIPHLDGMLLAKTLNQFKSRPKIVFITAYESYAVDAFSLDVFDYILKP
                     YSEERIISMLNKLEKSEMSDIELFNVNSNLYKYKKEAVNQEIEEITHKISLWKGDKLV
                     VIDIDDIYYCEANERQTFIYTEKEKFILKEGISEVENLINDKTFFRTHRSYIVNLTKV
                     KEIIPWFNNTYILKLKNSDYEVTVSRSKVKEFRLLMHI"
     gene            complement(2450..3652)
                     /locus_tag="KR257_003711"
     CDS             complement(2450..3652)
                     /locus_tag="KR257_003711"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426902.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="histidine kinase"
                     /protein_id="HBH0032365.1"
                     /translation="MKTSILIALIEKTSLIVVLFLLITKLKIFKQIFQKEEYSFNDLV
                     CIALVFTFLAIFGTYSGINYMGSIVNTRIISIVSGGILFGPMVGITAGVFSGIHRYFM
                     DIGGITSVPCLLSSILAGVLSGFLYKRIPKQHRVMYGILVGMISESFTILLIYLISYP
                     HSLAIQIIGGIYLPLIVGQIGIGFVISIVEGIEKDKKDIEARNKAEIKALQRQINPHF
                     LFNSLNTIASFIRFSPDKARELIINLSTYLRYNLEYSDNLIDINKEIEQVKSFVEIEK
                     ARFGELLTVSYDIEDVNIKIPSLIIQPLVENAIIHGILESGRAGVVKISIKKLPYSLE
                     NTVRISIEDNGIGISEEIINNVYQDNMPENKIGLYNVHLRLKLMYGRGLNIRRIDNGT
                     LIVFYVKE"
BASE COUNT         1408 a          744 c          421 g         1609 t
ORIGIN      
        1 tttttatcct ttcagcaata aaaaagagac ttatctctat tttgagatag tctcttcttt
       61 gaacataatt taaatacaat tttttaattt ttatagttat tattttacta acttgccaat
      121 ttatgattat tttgttcttt aatatgtttt gcttttttaa agaataaaag accaagaatt
      181 attgctacaa taacacctat tccattagat atattaactg gtagtctaaa tccttctttt
      241 gcttgcatta tataactaaa tgttactaca gtcataaaaa gtgctggtaa tgtagttata
      301 taatggtttt tatttgcttt gactaaatat gcagaaccag tccacaacat tatcattgca
      361 agtgtttgat ttgcccaaga gaaatatctc caaattatat taaaatctat aaatgtaaga
      421 gcaacaccaa ctgcgaataa tggtaaagct attaaaaatc tatttttgac tgcatcttga
      481 ttataattca ttgcatctgc tattgtcagc ctagcacttc taaatgctgt atctccagaa
      541 gttataggac atgccacaac tccaagtata gctaaagctc ctccaatagg ccccattaat
      601 ccaacagata ctgtatttac tactgttgct gctccaccat cattaaatat cacattaagt
      661 tgaggtatgc catggaaata tgacatggct gctgctgccc aaactaaagc tattatacct
      721 tctgcaacca ttgacccata aaatactggt cttgcctcac tctctttctc aacacatctc
      781 gccataagtg gtgattgagt tgcatgaaaa cctgatattg ctccacatgc tattgttata
      841 aataagtatg ggaataaagg tgttccattt ggattcatat tttgtaaatt tatatttggt
      901 atgttatacc cctttattat taatcctcca gctacaccta ctgccataat taataatgct
      961 gctccaaata aaggatatat tttaccaatc aatttatcta ttggtaaaac agtagccata
     1021 atataataaa gtattatcac tccaacccat atttgtgcgt ttacacctgt caatgtcttt
     1081 aataatcctg ctggacctgt tacaaataca actccaacca atactaaaag aataacacta
     1141 aatattctca ttgctatttt tgcaccattt cctagataaa ggcctaccaa ctctgatgca
     1201 gatgtacctt tgtttttcat tgatagatat cctgaagcaa aatcgtgtac tccaccagca
     1261 aagattgttc caaacacaat ccataaaaat gctgatggtc caaataatgc tccttgtata
     1321 gctccaaata tcggacctaa ccctgctata tttagaaact gaattaaaaa gattctcttc
     1381 catttcattg gcacataatc tactccatcc ctacaagcta tagctggagt ttgatttttg
     1441 tcattggttc caaaaacctt ttctacaaaa gtaccataga caaaataacc tactataagt
     1501 actactattg aacctaaaaa gcttaccata aattcatccc cttagttttt atataattgc
     1561 tttataaatt tttatgagtt taagaaaact atttccagtt caaatagtaa tactttttta
     1621 tgctaatata aatattaatt acattaagtg catatttaag tacatgaaat gactttatat
     1681 atgcattaac agcctaaatt cttttacttt gcttctactt acagttactt cataatcact
     1741 attttttaat tttaatatgt atgtattatt aaaccatggt ataatttctt ttactttggt
     1801 taagtttacg atataagacc tatgtgttct aaaaaatgtt ttatcattta taagattttc
     1861 gacttctgat atgccttctt ttaatataaa cttttctttc tcagtatata taaatgtctg
     1921 cctttcatta gcttcacagt aatatatatc atcaatatct attacaacta atttatcacc
     1981 tttccaaagg ctaattttat gtgttatttc ttctatctcc tgatttactg cttccttctt
     2041 atatttgtat aaattactat ttacattaaa tagttcaata tcactcatct cacttttttc
     2101 taatttattc agcatagaaa taattctctc ttcagaatat ggtttcaata tataatcaaa
     2161 tacatccaaa gaaaaagcat ctactgcata actttcatat gctgttataa aaacaatttt
     2221 aggtcttgat ttaaactgat ttaatgtttt tgcaagtagc attccatcaa gatgaggtat
     2281 atttatatct aaaaaaatta catctatttt attttcctga ataaagtcta acacctctat
     2341 accattggta aattcactta ctacctcgat tccactttta ttttcaataa aatatctcaa
     2401 ttcctttctt gctggaaatt catcttccac tattatagct ctcatacttc tactccttta
     2461 cataaaatac tatcaaagtc ccattatcta ttcttcttat attaagccct cttccataca
     2521 tcagtttaag ccttaaatgt acattataaa gcccaatctt attttctggc atattatctt
     2581 gatatacatt atttataatt tcctcactta tacctatacc attatcctct attgatattc
     2641 tcacagtatt ttctaatgaa tacggtaact tttttatgga tattttcact acaccagctc
     2701 taccactttc taaaatacca tgtattattg cattttccac taatggttgt ataatcaaac
     2761 ttggaatctt tatatttaca tcttctatat cataagatac agttagtaat tctccaaacc
     2821 tagctttttc tatctctaca aaagatttaa cttgttcaat ctctttattt atatcaatta
     2881 agttatcact atattcaaga ttatatctta gataagttga taaatttatt attaactctc
     2941 tagccttatc tggactaaat cttataaatg aagctattgt gtttagggaa ttaaacaaaa
     3001 aatgtggatt aatttgtctt tgaagtgctt ttatttctgc tttatttctc gcttctatat
     3061 cttttttatc tttctcaatc ccctctacta tagatataac aaatcctatt ccaatctgcc
     3121 caactattaa aggtaaatat attccaccga ttatttgaat tgctaaagaa tgtggatatg
     3181 atattaagta tataagtaat atagtaaaac tttcagaaat catgcctacc aatattccat
     3241 acattactct atgttgtttt ggtatcctct tatatagaaa tcctgataat acacctgcta
     3301 gtatacttga taaaagacat ggaacagatg ttatcccccc aatatccata aaatatctat
     3361 gaatccctga aaaaactcct gctgtaatac ctaccatcgg accaaataaa atgccacctg
     3421 atactataga tattattcta gtgtttacta ttgaccccat ataatttata ccactataag
     3481 ttccaaatat ggctaaaaaa gtaaaaacta atgctataca gaccaagtca ttaaaactat
     3541 attcttcctt ttgaaatatc tgcttaaata tttttaactt tgttattaga agaaacaata
     3601 ctacaataag gcttgtcttt tctattaatg cgattaaaat tgatgttttc ataatctccc
     3661 tttaaaaaat aaatttttac acactctaaa tttattatgg ttgttataaa ttacatattt
     3721 gaagtaatcc tatcacaaaa ctttccacat ttaatctttt aattaaataa gaaatagttg
     3781 tacttctatt aacaactaat actagctagc ataagcttgt aataacttgt agttattatt
     3841 aactttacaa ttctagtatt taattttata ctttagaaat ctcttttctt agaaataata
     3901 ctttcgaata tcatataata caatattatg tagattctta ctcatacaac atatttcttt
     3961 aaaaatttta tactattctt tgttcaaata tctcatttga tttaattgtg ttaaacacac
     4021 attatcatct ctctgttata tatttattat atagccgtat atcgataaag taaataaatc
     4081 ccatatttaa aataatatgt ttgacaataa attattataa tgtatattta ccataataat
     4141 ttgtcaacct tgaaagttac ttctataatt attgttaaat aa
//
LOCUS       DAEPID010000154         4104 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.157, whole genome shotgun sequence.
ACCESSION   DAEPID010000154 DAEPID010000000
VERSION     DAEPID010000154.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 4104)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4104)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4104
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.157"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            complement(27..512)
                     /locus_tag="KR257_003712"
     CDS             complement(27..512)
                     /locus_tag="KR257_003712"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889961.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SH3 domain-containing protein"
                     /protein_id="HBH0032366.1"
                     /translation="MISELMLKNFRKSSINFKTKIKLNLREKPDINSLKLKSIPEGKI
                     VKLKCVDGIWAEVESNYDKGWLLYKYLERLSNAKNNSNDTIKNRKKNYIGNIRTNGLS
                     LELRNDRTLESKVITTIPDGFKVEVCYSVGKWARVNINKNEKRYSGYVYNQYIEEHLS
                     L"
     regulatory      complement(595..688)
                     /regulatory_class="riboswitch"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF01051"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="cyclic di-GMP riboswitch class I; Derived by
                     automated computational analysis using gene prediction
                     method: cmsearch."
                     /bound_moiety="cyclic di-GMP"
                     /db_xref="RFAM:RF01051"
     gene            complement(1042..1425)
                     /locus_tag="KR257_003713"
                     /pseudo
     CDS             complement(1042..1425)
                     /locus_tag="KR257_003713"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003431032.1"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="BlaI/MecI/CopY family transcriptional regulator"
     regulatory      1651..1748
                     /regulatory_class="riboswitch"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF01051"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="cyclic di-GMP riboswitch class I; Derived by
                     automated computational analysis using gene prediction
                     method: cmsearch."
                     /bound_moiety="cyclic di-GMP"
                     /db_xref="RFAM:RF01051"
     gene            1803..1979
                     /locus_tag="KR257_003714"
     CDS             1803..1979
                     /locus_tag="KR257_003714"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729350.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0032367.1"
                     /translation="MFGNKMDKCTHVLTAYISSSYDYCNFLDTQLDDFILEYGENVVE
                     SCLHQVMVLVSKYN"
     gene            2205..2405
                     /locus_tag="KR257_003715"
     CDS             2205..2405
                     /locus_tag="KR257_003715"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003723180.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cold-shock protein"
                     /protein_id="HBH0032368.1"
                     /translation="MNNGIVKWFNNEKGFGFISMEGRDDVFAHFSAIQTSGFKSLEEG
                     QQVSFDIVKGARGPQAENITIL"
     gene            complement(2569..2781)
                     /locus_tag="KR257_003716"
     CDS             complement(2569..2781)
                     /locus_tag="KR257_003716"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428885.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0032369.1"
                     /translation="MVCKIFITLKTILPKTQIIVTTHSPHILQIDSKEEMIVLDMAES
                     DNVYKKELKLGEYGVLGWTNEGLYLH"
     gene            3156..3338
                     /locus_tag="KR257_003717"
     CDS             3156..3338
                     /locus_tag="KR257_003717"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428886.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="integrase"
                     /protein_id="HBH0032370.1"
                     /translation="MFKFYNNATLMFLPGTNIKTISERLGHADIKITMNSYSQFLEEM
                     DREAFENLSKILFIVF"
     gene            3409..>4104
                     /locus_tag="KR257_003718"
     CDS             3409..>4104
                     /locus_tag="KR257_003718"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889966.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0032371.1"
                     /translation="MNIIKSITLLLTLLIVILMTGCSPRESASEVAKKYIDKMNSGDY
                     ETAYSLLSKDSKKKISIENLEEFQNILVSTKRIISYKIGKEKIIKKYKHDGKEYKNVV
                     KLEETFNIKNLLYKKDDSLKVNRYFVVENNKYKLLLYESFKKEFGINSMDLAQLKLND
                     FGLKYFKEVDLILKKAIAINPTDSKLYYAQACNYMNFDGFPGYSDTTYNALDSINKSL
                     KYLDKNDSDYKKNA"
BASE COUNT         1493 a          523 c          478 g         1610 t
ORIGIN      
        1 tatatttaaa gcttgctagt atcgtattat aaacttaaat gctcttctat gtattgatta
       61 tatacatatc cagaatatcg tttttcattt ttattgatat taactcttgc ccattttcca
      121 acgctataac atacttcaac tttaaaacca tcagggattg tagttataac tttagattct
      181 aatgttctat catttctaag ttctaaactt aatccatttg ttcttatatt tcctatgtaa
      241 ttcttttttc tattttttat tgtatcatta ctattgtttt tagcattact taatctttct
      301 aaatatttat aaagtaacca acctttgtca taattactct caacttctgc ccatattcca
      361 tctacacact ttaacttaac aattttacct tctggtatac tttttaattt caaactattt
      421 atgtctggtt tttctcttaa attcaattta attttagtct taaaattgat gctagatttg
      481 cgaaaatttt ttaacattaa ttcagatatc atcttaagcc ctcctcttgc caaatattaa
      541 gttattaaaa tatataactc taaaaatact tttaacaaaa agaattatta tctttttggc
      601 aactggctga catgaccttt attacataaa gattttagtc cctatagttt tgcgtcatta
      661 gatttatcta atattgccta tatctgaata ataacataat ttgaacaatt aaaaaataat
      721 attacctcaa attttatatt atttaaatat aaattaaatt tttaattaat aataatcaaa
      781 aaatatcttt atatttattc aattactgtt ctttatagtc aatataaaag acagtaattt
      841 atctatagtg ttacttatat tttatatata tggctatttt tcaacatttt acaatatata
      901 acatttattt ttttaacttt tgtcagtaaa atgtcagcaa aacactttat ccacaatttt
      961 tatataagtt ttccacaact tatcaccaat attatccaca taaaaaaggt agcacttata
     1021 ttattagcta ccttttattt attaatcttt atatttccag ctttttatcc aacttcctat
     1081 ttctattatt ttttcttcag ttatttcttc tccatcatgt aattttgaaa ttaattctga
     1141 taaaggattg ttatgtaaac ctctaaaaac tctttttccc tctattttga gatattctct
     1201 ctcttttatt aatactgtat agtgtacatg cctcccaatt ctctatgata ttaaaaaacc
     1261 ttttttggtt aatctagcta aaagtataat tgtagttgta tgcttccaac catatgtttt
     1321 ttctatttca tctgcaacat cttttgatat tacagtttta taaccagtat gccatatgca
     1381 tttcataatt tttaattctg tatctggtaa ttttttattt agcataatat attccttctt
     1441 tcaatttatg tcacttcttc aaatttatct agcttaaatt ataataggag ctttttagaa
     1501 caaaaactat atttaatttt taccaggtac tctacgtgtt tagtctgttt ttaagtgtaa
     1561 aataatgttc atatctataa atttatttaa ctttcaaaca atcctgttga ataataacta
     1621 attctattgt attattttag ttgtagaata aaactaaatc ggcaaaacta gagaaattta
     1681 gtgacgcaaa gctataggga ctaagactta tataaatatc ttatgagtta tgtcagccag
     1741 ttgccaaaga gatagtgttc tttttgtttt tatgaaagtt ttttaggggg ataataattt
     1801 atatgtttgg aaataaaatg gataaatgta cacatgtatt gactgcttat attagcagtt
     1861 cgtatgatta ttgtaatttt ttagatacac agttagatga ttttatatta gagtacggag
     1921 aaaatgtagt agagtcttgt ttacaccaag taatggtatt ggtaagtaag tataattaga
     1981 tagacattga tttctagaaa acccttttta gttttatcta catttatatt aatatatagc
     2041 aatgtaaaac gtttaaatat atttttaata ttaagaataa ttaaaatgtt aactaaaaaa
     2101 tataattaag tagacatttc tattaatcta tgatacaata gtatttgtgg taatacacaa
     2161 ttaaatcaag tatatcttga tataggttaa taggagtatt tttaatgaat aatggaatag
     2221 tgaaatggtt taataatgaa aaaggattcg gttttatatc aatggaaggt agagatgatg
     2281 tgtttgctca tttctcagct atacaaactt caggatttaa atcattagaa gaaggtcaac
     2341 aagtaagctt tgatatagtt aaaggtgcta gaggtcctca agcagaaaat ataactatat
     2401 tataatatat agatttttcg ggaaagactc tttttagagt ctttttttat tgttaatata
     2461 tgtaagataa tcattggtga agtaaataag gtatattgag taatgttctt gatagtttat
     2521 atgctaatga atttcaaaaa aataagcact cctataaaaa gagtgctctt aatgtaaata
     2581 taaaccttca ttggtccagc ctaatacccc gtattctcca agttttaact cttttttata
     2641 tacattatca ctttcagcca tatctaacac aatcatttct tctttagaat caatttgtaa
     2701 aatatgagga ctgtgtgttg tgacaattat ttgtgttttt gggagaattg tttttaatgt
     2761 aataaaaatt ttacatacca catagttgat ataaaactta agactagcag actcataagc
     2821 aattagttgc ctctctttac ataccacata gttgatataa aacctagagg ctctcagaga
     2881 agttataaga tgtttagtaa ctttacatac cacatagttg atataaaact ccaaaataaa
     2941 cttagcatct ccaatgttta cacatataca atgctcttaa aattgcagtg aacgcgcaat
     3001 attgcaattg ataatactta tcatatattc tcaatacctt atatttcaac tgctaaacct
     3061 caatttatca caaatatcgc tcactgcaaa atttctatat ttttattata tcatagcata
     3121 taattaatat tttcaattaa tttttacatt taattatgtt taaattctat aataatgcaa
     3181 ctttaatgtt tcttcctgga actaatataa aaactatttc agaaagatta ggtcatgcag
     3241 atataaaaat aactatgaat agctactctc agtttttaga agagatggac agagaagcat
     3301 ttgaaaattt gagcaaaata ctatttattg tattttaaag aagatgactt attcaatatt
     3361 tgatgctaga atataattaa taaaaattta attataggtg attgtattat gaatattatt
     3421 aaaagcataa ctttactctt aacattatta attgtgatat taatgacagg ctgttcccca
     3481 agagaaagtg ctagtgaagt tgcaaaaaaa tatattgata agatgaactc tggtgactat
     3541 gaaacagcat atagtttatt aagtaaagat agtaaaaaaa aaattagtat agaaaatctt
     3601 gaagaatttc aaaatatttt agttagtaca aaaagaataa ttagttataa aataggtaaa
     3661 gaaaaaatca taaaaaaata taaacatgat ggaaaagaat ataaaaatgt tgttaaatta
     3721 gaagaaactt ttaatataaa aaaccttctt tataaaaaag atgattctct aaaagtaaat
     3781 agatattttg tagttgaaaa taacaaatac aagctattat tgtatgaaag tttcaaaaaa
     3841 gaatttggta ttaatagtat ggaccttgct caacttaagc ttaatgattt tggactaaaa
     3901 tactttaaag aagttgacct tatactaaaa aaagctattg ctattaatcc tactgattca
     3961 aagctttatt atgcccaagc atgtaattat atgaattttg atggatttcc tggttattca
     4021 gatacaacat ataatgcttt agattcaatt aataaatctt taaagtattt agataaaaat
     4081 gattctgact acaaaaaaaa tgca
//
LOCUS       DAEPID010000155         3905 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.158, whole genome shotgun sequence.
ACCESSION   DAEPID010000155 DAEPID010000000
VERSION     DAEPID010000155.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 3905)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3905)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3905
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.158"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            complement(165..365)
                     /locus_tag="KR257_003719"
     CDS             complement(165..365)
                     /locus_tag="KR257_003719"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003723180.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cold-shock protein"
                     /protein_id="HBH0032372.1"
                     /translation="MNNGIVKWFNNEKGFGFISMESGDDVFAHFSAIQTSGFKSLEEG
                     QKVSFDIVKGARGPQAENITIL"
     gene            complement(590..766)
                     /locus_tag="KR257_003720"
     CDS             complement(590..766)
                     /locus_tag="KR257_003720"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729350.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0032373.1"
                     /translation="MFRDKMDKCTHMLTAYIGSSYDYCDFIDTQLDDFILEYGEKVVE
                     SCLHQVMVLVSKYN"
     regulatory      complement(820..909)
                     /regulatory_class="riboswitch"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF01051"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="cyclic di-GMP riboswitch class I; Derived by
                     automated computational analysis using gene prediction
                     method: cmsearch."
                     /bound_moiety="cyclic di-GMP"
                     /db_xref="RFAM:RF01051"
     gene            complement(1089..1289)
                     /locus_tag="KR257_003721"
     CDS             complement(1089..1289)
                     /locus_tag="KR257_003721"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454608.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HBH0032374.1"
                     /translation="MPKFTCNLKKYRQLKELTQEQLAEKVGVRRETIMRLEAGKYNPS
                     LKLAIDISKIVDTPIDELFIFD"
     gene            complement(1291..1641)
                     /locus_tag="KR257_003722"
     CDS             complement(1291..1641)
                     /locus_tag="KR257_003722"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454606.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3796 domain-containing protein"
                     /protein_id="HBH0032375.1"
                     /translation="MIQKKFFMGFCGFLGFLSLRYFSSGNVADLTYIGFFAFFSNFII
                     SKINGDKADERYVQDEKAAMAFTGQLAIIELFILWCITIVSRNIELMCVLLSITYAIT
                     LNVYAIKLYILEEK"
     gene            1803..1992
                     /locus_tag="KR257_003723"
                     /pseudo
     CDS             1803..1992
                     /locus_tag="KR257_003723"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890498.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
     gene            complement(2469..2639)
                     /locus_tag="KR257_003724"
     CDS             complement(2469..2639)
                     /locus_tag="KR257_003724"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897489.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0032376.1"
                     /translation="MHVYQPKTSEYLLNTYAKSYLSSIVFLFDYITKNESGYAFFIID
                     FPFLSLDIFYKF"
     gene            complement(3028..3522)
                     /locus_tag="KR257_003725"
     CDS             complement(3028..3522)
                     /locus_tag="KR257_003725"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861519.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="prepilin-type N-terminal cleavage/methylation
                     domain-containing protein"
                     /protein_id="HBH0032377.1"
                     /translation="MKNKKGFTLVELLVVIAIIGILAIVALPALFKNIEKAKIAKLEA
                     DISAIKSASLSYYADESKYTDGGMISWVKKDGKIIINGGFKDDPLADKIENLGMPYNG
                     SYLLMSSPGHEKYLELSILPEGEISKSGLDKLKSDYGSSIDIMNEQNKIDIVIKFLND
                     KSNT"
BASE COUNT         1510 a          516 c          421 g         1458 t
ORIGIN      
        1 gtacatactt tataaatata tttttgtcag atttatttta taaaaagtat ttagactaag
       61 tattattttt aagtattttt ttgttgaagt tattttttcc ttttttacaa aatgcgtaaa
      121 taaaaaaaag actcttaaaa gagtctttcc gaaaaatcta tatattataa tatagttata
      181 ttttctgctt gaggacctct agcgccttta actatatcaa agcttacttt ttgaccttct
      241 tctaatgatt taaatcctga agtttgtata gctgagaaat gagcaaatac gtcatctcca
      301 ctttccattg atataaatcc aaatcctttt tcattattaa accattttac tattccatta
      361 ttcattaaaa atactcctat taacctatat caagatatac ttgatttact tgtgtattac
      421 cacaaatact attgtatcat agattaacat aaatgtctat ttaattataa tttttagtta
      481 acatttttat ttattcttaa tatgaaaata aatttaaaca ttttatatta ccaatatatt
      541 aatgtaaatg tagataaaac taaaaagggt tttctagaaa aaaatctgtc taattatact
      601 tacttaccaa taccatcact tgatgcaagc aagattccac aactttttct ccgtactcta
      661 atataaaatc atctaactgt gtatctataa aatcacaata atcatatgaa ctaccaatat
      721 aagcagttaa catatgtgta catttatcca ttttatctct aaacataatg tatttatccc
      781 cctaaaaaac tttcatgaaa aacaaaaaga aaatatcttt ttggcaactg gctgacataa
      841 cttattttat aagcgttagt ccctatagct ttgcgtcact aaatttctct agttttgccg
      901 atttagtttt attctacaga ttaataatac aatagaatta gttattattc aacatatcta
      961 gctgaaaaat taataaattt atatatgaac gttaaattat ctgaaaaaat aaaaagcccc
     1021 tctgtcagga gtgacttaaa aattgaattt aagtttgtat ttaaaacaca tttttaataa
     1081 tgcaaaaact aatcaaaaat aaacaattca tcaataggtg tatctactat ttttgatata
     1141 tctattgcta atttcaaaga aggattatac tttcctgctt ctaaacgcat aatggtttct
     1201 cttctaactc ctactttttc tgctaattgt tcttgagtta attcttttaa ttgtctatat
     1261 ttttttaggt tacaagtgaa tttaggcata ttatttttcc tctaaaatat aaagttttat
     1321 agcataaaca tttaaagtga ttgcatatgt aattgatagt aaaacacaca ttaattctat
     1381 attcctagac actatagtaa tacaccataa aatgaataat tctataatag caagctgtcc
     1441 tgtaaatgcc atagctgctt tttcatcttg tacatacctt tcatctgctt tatcaccatt
     1501 tatttttgat ataataaagt ttgagaaaaa agcaaaaaat ccaatatatg taaggtcagc
     1561 aacattgcca gatgaaaaat atctaagact taaaaatcca aggaaaccac aaaaacccat
     1621 aaaaaatttt ttctgaatca ttttttatcc tccttagtaa ttttaaaaga gatatattta
     1681 tatctttatg atacaaatat atctctttta tattcttttg tcaatagaaa atcagtatta
     1741 tacaatattt gtactgcacc ataattgtta gagcaaaaat ctactgcttg agatgtttat
     1801 gtatgactaa atatgatttt aatttcaaat taaaagtagc taaattttat ttgaatagag
     1861 aaggaagaga tattttaata gtaaaacaat atggagttta taaccattct caagttgaaa
     1921 gatgggttaa tatattagga gagtgtgcac taaaaataaa aaaaattttc tatactatat
     1981 ggttcaagtt agatgttata aactatatga tgataactaa atatagtgta caataaatcg
     2041 ctaagtattt tggaataaac aatagcacag ttatagcaac atgaaaataa aaatttttac
     2101 atagtggtgt tgatgccttt tctaaaatga aaggaagacc ataatgaata aaaacaaaaa
     2161 cactaaagaa aaaataaatt aacaagagaa caagaattag aatatgaaaa taaattttta
     2221 aaagatgagc ttgagttttt aaaaaagatg tgtgcctcag ggaagccaca ttaaaaaaca
     2281 gtggtatcat tattaatcaa aagaaagtta gatgtattat caaaaaatta gaacttaaat
     2341 gcatagcatt ttttcataaa tcacataaat ataactccta taaatgtata attggaaaag
     2401 taaaaaataa taaaacaaat agaagattta aaatatcaat agcatatcag aaaataacaa
     2461 atgatatgct agaatttata aaatatatct aatgataaaa atggaaaatc aattataaaa
     2521 aaggcatatc ccgattcatt ttttgttata tagtcaaata agaatactat agatgaaaga
     2581 tacgattttg catatgtatt aagtaagtat tctgatgttt ttggttgata cacatgcaat
     2641 aaagaagttg tgtttgcaga taaattagca aaactatagt ataagttgca acaataaaga
     2701 aaatgaaaat tatcatacta aagcataagg catgttacaa ttttattaga taggacatta
     2761 acatacatta aagtactttt tattataaag agtacttatt tttttgaaat tcattaatgt
     2821 ataaactatc aagaatatta ctcaacataa tttaaaaaca acttgaatag gtatttttaa
     2881 attatgtgat ataataaaaa atagaagtgt atgccaatac acttctgtaa ttataactaa
     2941 gcattctatt cttgaggagt gcttttttca tttctccaaa caagattgtt tatttcatca
     3001 gcaattatta aataaaattt attgtattta agtattcgat ttatcattta aaaattttat
     3061 tacaatatct attttgtttt gctcgttcat tatgtctatt gaacttccat aatcactttt
     3121 taatttatct agaccacttt tgcttatttc tccttctgga agtatactta attctagata
     3181 tttttcatga ccaggagatg acattaatag atatgaacca ttataaggca tacctaaatt
     3241 ttctatttta tctgctaatg ggtcatcttt aaagccacca tttattatta tttttccatc
     3301 tttctttacc catgatatca ttcctccatc agtatatttt gattcatctg catagtagct
     3361 aagagacgca ctttttattg cacttatatc agcttcaagt ttagctatct ttgctttttc
     3421 tatattttta aataatgctg gaagtgctac tattgccaat attcctatta tagcaattac
     3481 tactaataat tccactagag taaatccttt tttatttttc atttatttcc cctccatata
     3541 aaattaataa tatataaatt tttattttgt tgatttctac tttctatatt ttaccatata
     3601 tagacaaaaa aatcactttc tatgacaaat atactattat tttacaattt atggaaatga
     3661 tttaaaatga catttcttgt tagaaaagat ataagaaatg gattaaaata aagaaaacta
     3721 cagtcatatc aatgtcaata atattattta aaagcagatg aaaataaaaa gaggactcag
     3781 aaaataatgt ctatttaatt atacttactt accaatacca taacttgata taaacaagat
     3841 tatactacat tttttttatg ctctagtata aaatcatcta actgtgtatc tataaaatca
     3901 aaata
//
LOCUS       DAEPID010000156         3814 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.159, whole genome shotgun sequence.
ACCESSION   DAEPID010000156 DAEPID010000000
VERSION     DAEPID010000156.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 3814)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3814)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3814
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.159"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            45..713
                     /locus_tag="KR257_003726"
     CDS             45..713
                     /locus_tag="KR257_003726"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903182.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0032378.1"
                     /translation="MENITSYFTTILCVFICLSSVFIFTQLARVFINKKKINQKIKSR
                     NGFRYDRDFIEARREEIHIKDNNNNKNKSNNKKLKEEKVFKYDNGDLYKGEFVDGKKN
                     GFGIYIFSGKEKYEGLWKDDKMHGIGKYTYRDGSIYTGEFKYGLKNGLGKLTYPNNDI
                     YKGYFLDNKKNGKGVLYKNDGNKQAGIWEDDEQCKSLDFKDLNNNKINNVYQNRLNNN
                     KLKV"
     gene            872..1378
                     /locus_tag="KR257_003727"
     CDS             872..1378
                     /locus_tag="KR257_003727"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454691.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="3'-5' exonuclease"
                     /protein_id="HBH0032379.1"
                     /translation="MKEYVVVDLETTGLDPYKGCEIIEIGITEIKNEQIVKNYSRLIK
                     PKGIISSFITELTHISNEMVENEEPLELVLPRFRKYIGDRTIIAHNAKFDLKFLNYYL
                     RMLDLEPINNYICTVELLKKCKSYKGKNKKLETACAYYNIENINAHRADSDTLATAKL
                     FLKIKDEY"
     gene            1506..2522
                     /locus_tag="KR257_003728"
     CDS             1506..2522
                     /locus_tag="KR257_003728"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430829.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transglycosylase domain-containing protein"
                     /protein_id="HBH0032380.1"
                     /translation="MGYYNDNDNNKIRRKKISNNKDSNKKSKHSYTSANKKNKSPNTS
                     SSKRMSEKVDSQNLIKRDRDSFTRDNVRPLNTDYNQRERRRVEYKQREKKLKSKKRKK
                     QKRIRIVRALLSIMLVALIIFSVAGAIFTVSAIKGSPEVTKKLIRSKYISSEVVSIKQ
                     MPNDLKHAIVSIEDERFYKHKGVDVISLVRSVLNNVFTDTTQGASTIDMQVSKNLLTS
                     NDKTMKRKIRDMYNAKQMNKIMTKDEILEAYLNNMYLGKNAYGAAKGAEVYFGKKVSE
                     LNLAECAMLAGMTNNPARYIDHGEAKKRQVIVLYKMHQLGYITDKEYRIAKADDTPFK
                     SEID"
     gene            2876..3580
                     /locus_tag="KR257_003729"
     CDS             2876..3580
                     /locus_tag="KR257_003729"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454689.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="B3/4 domain-containing protein"
                     /protein_id="HBH0032381.1"
                     /translation="MKKFVIEDAFWNLFPSAKIGVVICNDIDNSIKDEDYKKIILKGE
                     EEALKYLEDSEFSNNQVIKVWREAFKKFKTKKGARSSIEALLKRVHNGNNIGTINPLV
                     DIYNFISLKYALPCGGEDIDKFIGDIRLTRAIGNEEFIPLGTDENSFPYEGEIIYKDD
                     GGAICRCWNWREAVRTMLTEDTNNAFLCIELVDESRFKEFENALNELAKIVQEKLGGN
                     CKISILDIDNKEVSVD"
BASE COUNT         1632 a          324 c          658 g         1200 t
ORIGIN      
        1 ttatattagg tattttaaat aaatttttta aagggtgatt ttttatggaa aatataacta
       61 gttattttac aacaatacta tgtgtattta tatgcttatc atctgtattt atatttactc
      121 aactagctag agtatttatt aataagaaga agattaatca aaaaattaaa tcaagaaacg
      181 gatttaggta tgatagagat tttattgaag ccagaagaga agaaatacat ataaaggata
      241 acaataataa taaaaataag agtaacaata agaaattaaa ggaagaaaaa gtatttaaat
      301 acgataatgg tgatttatat aaaggtgagt ttgttgatgg aaagaaaaat ggatttggaa
      361 tatatatttt ttcaggtaag gaaaagtatg aaggattatg gaaagatgac aagatgcatg
      421 gaataggaaa atatacttat agagatggtt caatatatac aggtgaattt aaatacggat
      481 taaaaaatgg tttgggaaaa ttaacatatc ccaataatga catttataag ggatattttt
      541 tagataataa gaaaaatggt aagggtgtat tatataaaaa tgatggaaat aaacaagcag
      601 gaatatggga agatgatgaa caatgtaaaa gtttagattt taaagattta aataataata
      661 aaataaataa tgtttatcaa aatagattaa ataacaataa attaaaagtt taattattct
      721 aataaaaaaa tctttattta tgatggaata taggatatat ctatgttgta atttgtaaaa
      781 tcttcctata tcatataaaa ttaagtattg attagtctat tacataaata tagaatataa
      841 atatatccat ttaataataa ggagaagaga tatgaaagag tatgtagttg tggatttaga
      901 aactacagga ttagatccat ataaaggttg tgaaataata gaaataggaa taacagaaat
      961 aaaaaatgaa caaattgtaa aaaactattc aaggttgata aaacctaagg ggataatttc
     1021 ttcatttata acagaattga cacatataag taatgaaatg gtagaaaatg aagaaccact
     1081 agaattagtt ttacctagat ttagaaaata cataggtgat agaactataa ttgcacacaa
     1141 tgcgaaattt gatttaaaat ttttaaatta ctatcttaga atgttagatt tagaaccaat
     1201 aaacaattat atatgtacag tagagttatt aaaaaaatgt aaaagttata aaggaaaaaa
     1261 caagaaactt gaaacagctt gtgcttatta caacatagag aatataaatg ctcatagagc
     1321 tgacagtgat acattagcaa ctgcaaaact atttttgaaa ataaaagatg aatattaatt
     1381 ataaatatag agaaaattag tgaaaatatc ctttataaaa ttgaccctta agcttacaat
     1441 tttgttcttt gatttatttt gtagaacaat gtataatgta ccttatatga agaagggaga
     1501 ctaaaatggg ttattacaat gataatgata ataataaaat aagacgtaaa aaaattagta
     1561 acaacaaaga tagtaataaa aaatctaaac attcttatac ttcggcaaat aaaaaaaata
     1621 aaagtcctaa tacaagttcc agtaaaagaa tgagtgaaaa agtagattca cagaatctta
     1681 taaaaagaga tagagatagt tttacaagag ataatgtaag acctttaaat acagattaca
     1741 atcaaagaga aagaagaaga gtcgagtata aacaaagaga gaaaaaatta aaaagtaaaa
     1801 aaagaaaaaa acaaaaaagg attagaatag ttagggcatt attatctatt atgttagttg
     1861 cactaattat attttcagtg gcaggtgcaa tatttacagt ttcagctata aaagggtcac
     1921 cagaagttac taaaaagtta attaggtcta aatatataag tagtgaggtt gtaagtataa
     1981 aacaaatgcc aaatgattta aaacatgcaa tagtttccat agaagatgag agattttata
     2041 agcataaagg agtagatgtt atttctctag ttaggtcagt attaaacaat gtgtttacag
     2101 atacaacaca aggtgcaagt actatagata tgcaagtttc aaaaaacctg cttactagta
     2161 atgataaaac tatgaagcgg aaaataaggg atatgtataa tgctaagcag atgaataaga
     2221 ttatgactaa ggatgaaatt cttgaagcat atttaaataa tatgtatcta ggtaaaaatg
     2281 catatggagc tgcaaaggga gctgaagtct actttggtaa aaaagttagt gaattaaatt
     2341 tagctgagtg tgctatgtta gctggtatga caaataatcc tgcaaggtat attgaccatg
     2401 gagaggctaa gaagagacaa gtgattgtac tgtataagat gcatcagctt ggttatataa
     2461 ctgataagga gtatagaata gcaaaagctg atgacactcc atttaaatca gaaattgatt
     2521 aaaattgtaa gaatatagta ttttcaatag tttaaacaaa caaaaatgta ataaaaaagg
     2581 tgatttgcca cccatttgcc accataatta taatctaatg gcaaattgtt ttaatgtaca
     2641 aactagataa tagaatattg tcttaaatgc tatattatgc taaaatttaa ttgtattttg
     2701 taaattaaaa aacttataat ttagttttct agggttccgc attttataat ggtcaggtcc
     2761 aagagaaaac gcgcaattgt tgtgtacacg gaaggataaa agcctgggag atatttaaga
     2821 atatttctat aggctttttt atttttacat attttaaatt tgaggaggtt ttctaatgaa
     2881 aaaatttgtt attgaggatg cattttggaa tctatttcct agtgcaaaaa ttggagttgt
     2941 tatttgtaat gatatagata actctataaa agatgaagac tataagaaaa taattttgaa
     3001 gggagaagaa gaagcattaa aatacttgga ggactcagaa tttagcaaca accaagtgat
     3061 taaagtatgg agagaagcat ttaaaaaatt taaaacgaaa aaaggagcaa ggtcttctat
     3121 tgaagcatta ttaaaaagag ttcataatgg aaataatata ggaactatta accctttagt
     3181 ggatatctac aattttatct cattaaaata tgcattacct tgtggagggg aggatataga
     3241 taaatttata ggagatatta ggctaactag agcaattggt aatgaggagt ttatcccact
     3301 agggacagat gaaaattcat ttccatatga aggagaaata atttataaag atgatggtgg
     3361 agcaatttgt agatgttgga attggcgtga agcagtgaga acaatgctta ctgaagatac
     3421 taacaatgcc tttttatgca ttgaattagt agatgaaagt agatttaaag aatttgaaaa
     3481 tgctttaaat gaattagcta aaatagttca agaaaaattg ggtgggaatt gtaaaatttc
     3541 aattttagat attgataata aagaggtatc agtggattaa tatggaggtg ctgttgtaat
     3601 ggactattct agttataaag atacttatat ttagggtaag aaggtctatt ttagatataa
     3661 cgattatcaa aggatataat atagaaaata aaaatgtaga atataaaaag cctttaaaat
     3721 aagaaaaaaa tgtattttaa aggcttttat tatactcttt tttatttgca taattaacaa
     3781 taaaaatata ttgttaatta taatattttt attt
//
LOCUS       DAEPID010000157         3770 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.160, whole genome shotgun sequence.
ACCESSION   DAEPID010000157 DAEPID010000000
VERSION     DAEPID010000157.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 3770)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3770)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3770
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.160"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            <1..847
                     /locus_tag="KR257_003730"
     CDS             <1..847
                     /locus_tag="KR257_003730"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015984839.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=2
                     /transl_table=11
                     /product="phage portal protein"
                     /protein_id="HBH0032382.1"
                     /translation="TYFVERGNSFVQEFLYDEYGKMTDIQEGHFRINNKEQGWGKVPF
                     ISFKNNEKCVSDLTFYKSLIDIYDNNISTLADNLDEIQEVIYVLKEYPGTSLQEFIDN
                     IRYYKSIKVDGGGGVDKLEINIPVEAKKELLDRLEKNIIIFGQGVNPESQNTGDKSGV
                     ALKFLYSLLDLKCSKTEKKFKKAIRELLWFVCEYLKISGSKSYDYKTVQITFNHSMII
                     NEAEKIDMAAKSTGIVSDETIVSNHPWVEDVNDELERLKKQEDTQKEYDDLIPNNQDG
                     VIDET"
     gene            837..2234
                     /locus_tag="KR257_003731"
     CDS             837..2234
                     /locus_tag="KR257_003731"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015984840.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="minor capsid protein"
                     /protein_id="HBH0032383.1"
                     /translation="MKHKDYWRKRFEQLEEAQNNKSVKYYLELEKQYKLAMNSIEKDI
                     LAWYNRFAKNEGISLLEAKKLLNTRELEEFKWSVEEYIRHGKENAINQKWMKELENAS
                     ARVHITRLEALKLQIQQQVEVLYGNELDGIDKLMRHIYTSGYYHAAFNVQQGVNVGWS
                     LMNLDTNRINKVISKPWTSDGLNFSERIWGKHRPALINELHTKLTQSIIRGENPKNLV
                     NDFSKRFNVSKSQAKNLIMTESAFFASASRKDCFNDLDVEKYEIIATLDLKTSNICRE
                     LDGKVFDMKDYQVGVTAPPFHCRCRTTTAPWFEDEEGYRAAKGEDGKTYYVPSSMKYN
                     EWYEKYVKHNSILEIKNSAIIDSIKEDIKNGKYNLNIHDGKQGKHLKEHNNYIEGRSY
                     LTITKEEAQELVNKHAGNGIIKFNRSGEWDKKELIEVDKNIGVNVNNITGEKTLTNKF
                     KIHYSKTGTHIVPAL"
     gene            2249..2449
                     /locus_tag="KR257_003732"
     CDS             2249..2449
                     /locus_tag="KR257_003732"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896618.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0032384.1"
                     /translation="MKLWEYVGKNVQITCVDKQIIRGKCDGYTQALDNEPEIASISIA
                     RDGYGIEVYENEIESIENINKE"
     gene            2515..3078
                     /locus_tag="KR257_003733"
     CDS             2515..3078
                     /locus_tag="KR257_003733"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728455.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phage scaffolding protein"
                     /protein_id="HBH0032385.1"
                     /translation="MDWLKELLEGIKIEDNKIDVASLQKSIEKKIKETTITQEDYTNL
                     ETQLNTANETIKKFEGGMTKEDVENLKTTYETDKKTLEETYKKEIEEKDFNYWLNDAF
                     KSIKCRDEIALKAHLDIEALRNSKDRQKAFEEQINPLKQDKDYLFNATLEGEEPKIDT
                     ITPGQEPKINDFGFNFTGVRPHENNNK"
     gene            3090..>3770
                     /locus_tag="KR257_003734"
     CDS             3090..>3770
                     /locus_tag="KR257_003734"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861029.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="capsid protein"
                     /protein_id="HBH0032386.1"
                     /translation="MAALNYAKEYSNVLAQAYPYTLNFGDLYATPNNGRYRWTGSKTI
                     EIPTISTTGRVDSNRDTIAVAQRNYDNAWEPKVLTNQRKWSTLVHPADINQTNYVASI
                     GNITKVYNEEQKFPEMDAYCISKIYADWTALGNTADTTVLTTTNVLEVFDKLMEKMTE
                     ARVPENGRILYVTPVVNTLIKNAKEIQRTVNIKDAGTSLNRQTTDIDTVKIIKVPSNL
                     MKTAYDFTT"
BASE COUNT         1616 a          406 c          697 g         1051 t
ORIGIN      
        1 aacttacttt gttgaaagag gtaatagttt tgttcaagaa tttttatatg atgaatatgg
       61 aaaaatgact gatatacaag aaggtcattt tagaataaat aacaaagaac agggatgggg
      121 taaagttcca tttatatctt ttaaaaataa tgaaaagtgt gtctcagatt taactttcta
      181 taaatcatta atagatatat atgacaataa tatttctaca ctagcagata acttagatga
      241 aatacaagag gttatttatg tattaaaaga atatccagga acaagtctac aagagtttat
      301 agataatata agatactata aatcaattaa agtagatggt ggaggtggag ttgataaact
      361 agagataaat ataccagttg aagctaaaaa ggagcttctt gatagattag aaaagaatat
      421 aattatcttt ggtcaaggag ttaatccaga atctcaaaac acaggtgaca aatcgggtgt
      481 agcacttaaa tttttatatt cattactgga ccttaaatgt tctaagactg aaaagaagtt
      541 taaaaaagca attagagagc ttttatggtt tgtgtgtgag tatttaaaga taagtggtag
      601 taagagctat gattataaaa cagttcaaat tacttttaat cactctatga taataaatga
      661 agctgaaaag atagatatgg cagctaaatc aactggaatt gtatcagatg aaactattgt
      721 ttctaaccat ccttgggtcg aggatgtaaa tgacgaactt gagagactta aaaaacagga
      781 agatactcaa aaagagtatg atgatttaat tcctaataat caagatggtg ttatagatga
      841 aacataaaga ttattggagg aagagatttg aacaattaga agaagctcaa aataacaaaa
      901 gtgtaaaata ttatcttgaa ttagaaaagc aatataaact agctatgaat agtatagaaa
      961 aagatatatt agcatggtac aacagatttg ccaaaaatga aggaatatct ttattagaag
     1021 ctaagaaact actaaataca agagaactag aagagtttaa atggagtgtc gaagaatata
     1081 ttagacatgg taaagaaaat gctataaatc aaaagtggat gaaagagtta gaaaatgcta
     1141 gtgcaagagt tcatataaca agacttgaag ctttaaagtt acaaatacag caacaagtgg
     1201 aagtgcttta tggaaatgaa cttgatggta ttgataaatt aatgagacat atttatacaa
     1261 gtggatatta tcatgcagct tttaatgttc aacaaggagt aaacgttggt tggagtttaa
     1321 tgaatcttga tactaataga ataaataaag ttatctctaa accatggact agtgatggat
     1381 taaattttag tgaaaggatt tggggcaaac atagacctgc tttaattaat gagttacata
     1441 ctaagctaac tcaatcaatt attagaggtg aaaatccaaa gaacctagta aatgactttt
     1501 ctaagagatt taatgtatct aaatcacaag ctaagaattt gataatgact gaatcagctt
     1561 tctttgcatc agcttcaaga aaagattgtt tcaatgattt agatgtagag aagtatgaga
     1621 ttattgccac actagactta aaaacatcaa atatatgtag agagttagat ggaaaagtat
     1681 ttgatatgaa ggattatcaa gttggagtta cagctccacc atttcattgt cgttgtagga
     1741 caacaacagc tccttggttt gaggatgaag aaggttacag agcagcaaaa ggagaagatg
     1801 gaaaaacata ttatgtacca tctagtatga agtataatga gtggtatgag aagtatgtta
     1861 aacataatag tatcttagaa ataaaaaata gtgctataat agatagcata aaagaagata
     1921 ttaaaaatgg taaatataat ttaaatattc atgatgggaa acaaggaaaa catttaaaag
     1981 agcataataa ttatatagaa ggaagaagct atttaactat aacaaaagaa gaagctcaag
     2041 aacttgtgaa taagcatgct ggcaatggaa tcataaaatt taatcgaagt ggagaatggg
     2101 ataaaaaaga acttatagaa gttgataaga atataggggt caatgttaat aatattacgg
     2161 gtgaaaaaac tcttacaaat aagtttaaga tacattattc caaaactgga acacatatag
     2221 taccagcttt ataaggaggg aaaataaaat gaaattatgg gaatatgtag ggaaaaatgt
     2281 tcaaataact tgtgtagata agcaaataat aagaggaaag tgtgatggat atacacaagc
     2341 tttagataat gaaccagaaa tagcaagtat atcaatagct agggatggtt atggaattga
     2401 agtttatgaa aatgaaatag aatctatcga aaatataaat aaggaatgac taagcatgta
     2461 cttaaaaata agtagatgct tttattttgt aaaaaatgaa aggagaaatt taaaatggat
     2521 tggttaaaag aattgctaga aggaataaaa atagaggata acaagattga tgtagcttct
     2581 ttacaaaagt ctatagaaaa gaaaataaaa gagactacaa ttactcaaga agattataca
     2641 aatcttgaaa cacagcttaa tacagctaat gaaactatta aaaagtttga aggaggtatg
     2701 acaaaagaag atgtagagaa tctaaaaaca acttatgaaa ctgataagaa aactttggaa
     2761 gaaacctaca aaaaagaaat tgaagaaaag gactttaatt actggttaaa tgatgctttt
     2821 aagtctatta aatgtaggga tgaaatagcg ttaaaagctc atttagatat agaagcacta
     2881 agaaatagta aagatagaca aaaagctttt gaagagcaaa taaacccttt gaaacaggat
     2941 aaagattatt tgtttaatgc aacactagaa ggtgaagagc ctaaaataga tactataaca
     3001 ccagggcaag agcctaagat aaatgatttt ggttttaatt ttactggggt aagacctcat
     3061 gaaaataata ataaatagga ggaaataaaa tggcagcact aaattatgca aaagaatatt
     3121 caaatgtttt agcacaagca tatccttata ctttaaactt cggggatttg tatgcaacac
     3181 caaataatgg aagatataga tggactggtt ctaaaacaat agaaatacca actatatcta
     3241 caactggaag agtagattca aacagagata caatagcagt agctcaaaga aactatgata
     3301 atgcttggga acctaaggta ttaactaatc aaaggaaatg gtcaacattg gttcatccag
     3361 cagatataaa ccaaactaat tatgtggctt caataggcaa tataacaaaa gtatataatg
     3421 aggaacaaaa gtttccagag atggatgctt actgtatatc taaaatatat gctgattgga
     3481 ccgcattagg taatacagca gatacaactg ttcttacaac aacaaacgta ttagaagtat
     3541 ttgataagtt aatggaaaaa atgacagaag ctagagtacc tgaaaatgga agaatattgt
     3601 atgttactcc agtagtaaat acacttatca aaaatgcaaa agagatacaa agaacagtaa
     3661 atataaagga tgcaggaact tctcttaatc gtcaaacaac tgatattgac acagttaaaa
     3721 taattaaagt accatctaat ctaatgaaaa ctgcatatga ttttacaact
//
LOCUS       DAEPID010000158         3757 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.161, whole genome shotgun sequence.
ACCESSION   DAEPID010000158 DAEPID010000000
VERSION     DAEPID010000158.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 3757)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3757)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3757
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.161"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            complement(227..514)
                     /locus_tag="KR257_003735"
     CDS             complement(227..514)
                     /locus_tag="KR257_003735"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429630.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0032387.1"
                     /translation="MRLNVTKQNTIEVENSRKEDVYFVIVDNVFFERQGDVFNSITNN
                     NLNNYDVKILPTDNVFLELKITSTKDLEPVFIVVEDRQYNHGSIMFKPVLV"
     gene            complement(534..809)
                     /locus_tag="KR257_003736"
     CDS             complement(534..809)
                     /locus_tag="KR257_003736"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860867.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0032388.1"
                     /translation="MSLFVGGWSKFRAVEEEDLKVFNEAVGMLEGVGYEPLIVSTQVV
                     AGTNFKFICNATSVTNPPQNYLAEIVVFKPLPCDEHNATITSINIIK"
     gene            complement(1446..1625)
                     /locus_tag="KR257_003737"
     CDS             complement(1446..1625)
                     /locus_tag="KR257_003737"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895603.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0032389.1"
                     /translation="MGKDRFEKVYSQGKINATEIWVDKETGVNYVFHYYGHAAGFTPL
                     LDREGKPVISPIVSK"
     gene            complement(1910..3385)
                     /locus_tag="KR257_003738"
     CDS             complement(1910..3385)
                     /locus_tag="KR257_003738"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729457.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GntR family transcriptional regulator"
                     /protein_id="HBH0032390.1"
                     /translation="MKRKPQYLIIFEHIIQQIYTGKITIGDRLDSIKSMSEEYMVSKN
                     TIKTVIKMLSEKGFIETKAGSRPVLIQSTSKQSIESDLLYEKILQISEIYKIFSLIFP
                     SIAMYNIKRFTSKDFEELNEIIDCMEKNSSNYLVFKEQRLKYINKLISKTNNFLIHHF
                     CEIIQHDVIISQLAYNFDNLDNLDNCCIDFFRNKYIEQVRKTYLYGLDGNLIEFKKLL
                     TYMYKACRESILKMVENRAPQSIDTSSFNSVTLEKCYLYDLIVSDVICQIFEGNIKIG
                     DCLPSITSIINRYNVSLPTVRSAYNELNELGIAKTINGKGTYITLFSEYDDDYINTEE
                     GAKRLSLLLDAMEFVTITLEDVVLLLGNKMDLIAVDKIETHLRYLQNNCEECKVYPDF
                     VLLCKIVDYTQIYVLQETFLHLKQYMIFGIYLERFFHEEYNEILKTRFDVCFEILRYL
                     KKGDVERFAESFSNIFKESLQYLKKVISSLNVDMRVKLDIL"
BASE COUNT         1318 a          586 c          379 g         1474 t
ORIGIN      
        1 caactatact ggtttaaata ggttatcttt atttgcttaa atagttcaac tatactggtt
       61 taaataggtt atctttattt gcttaaataa gttcaactat actggtttaa ataggttatc
      121 tttatttgct taaattagtt caactatact ggtttaaata gttttccttt agtttaaata
      181 attcacctat acctacttga atagttcact tttatttgct taaattctat accaatactg
      241 gcttaaacat tatactacca tgattgtatt gtctatcttc aactacaata aaaacaggtt
      301 ctaaatcttt agtagatgtt atttttaatt ctaaaaaaac attatcagtt ggtaatattt
      361 ttacatcata attatttaaa ttattattcg tgatactatt aaatacatca ccttgacgtt
      421 caaaaaaaac attatcaact attacaaaat aaacatcttc ttttctacta ttttcaacct
      481 ctatagtatt ttgtttagtt acatttagtc tcatcttcca cctcctatta atattactta
      541 attatattaa tacttgtaat tgttgcatta tgttcatcac aaggaagagg tttaaaaaca
      601 actatctctg ctaaataatt ctgtggagga tttgtaactg aagtagcatt acaaataaat
      661 ttaaaatttg ttcctgctac aacttgagta gaaacaataa gtggttcata accaacccct
      721 tctaacattc ctacagcttc attaaatact tttaaatctt cttcttcgac agctctgaat
      781 tttgaccatc caccaacaaa aagactcata taaaaacctc ctttatatat atatttattt
      841 atatatatag tagtaccaat tttctcaata ttcaatattt tctgtgtaac tggtcaatga
      901 aaatgcataa ctggataaaa atacttataa aataacttaa ctttacatat aaatagctta
      961 atttacatgt aataagatta ttctacaata tgaaatacat cttattttga atatattcta
     1021 aatacaataa tggatatttt caattattat acttagaaaa tatccattac ttaatttgtt
     1081 ttatttaaaa tcacatagag actttattat tttttttatt gcatgaatag ctatttcagg
     1141 tatcataagg tgatataccc cctccttgaa accacaaaaa acataacaaa ctttacgaat
     1201 cttgtcttaa aagaccacag gtacattcct tatttgtgga ttggagtagc cataacaagc
     1261 aaattttaca atttttatga tgacaaaaat caataaaatc gcttagtata taacacgaaa
     1321 tactacttgt tgctattaag aatagttaga taggaagtat gcattatacc aataaaggaa
     1381 tcaataaaga aagttaaaac atccctacaa attaaaaatc tgttacattt ttctatattt
     1441 aaacgttatt tacttacaat tggagaaata acaggttttc cttctcggtc aagtaaaggc
     1501 gtaaatccgg ctgcatggcc ataatagtgg aatacatagt tcacacctgt ttctttatcc
     1561 acccaaatct ccgttgcatt tatttttcct tgtgaatata ctttttcaaa tctatctttt
     1621 cccattttat aatcctccat atttttgatt ggtctatgcc ttcttcactt aagtagaaaa
     1681 aatacataac ttattttttt aattctaata tgagcacgta aaaatgtcaa acagcttatt
     1741 taatttcata acttcatgtt actgttcgta accttgtctg tttacttaca ctgcattaca
     1801 gcaccatttt atcctttaca ttattgtatt gcacacagta aaaatgctta ctttattgga
     1861 tttttcaact aaaaaaagga ttttttctcc acagaacatt tactattttt tataatatat
     1921 ctaattttac tctcatatca acatttaatg aagatataac ctttttcaaa tattgtaaag
     1981 actccttaaa aatattagaa aaagattctg caaatctctc aacatctcct ttttttaaat
     2041 acctaagtat ctcaaaacat acatcaaaac gtgttttcaa aatttcatta tattcttcat
     2101 gaaaaaatct ctctaaatag attccaaata tcatatattg ttttaaatgt aaaaatgttt
     2161 cctgtaatac ataaatttgt gtataatcta ctatcttaca aagtaaaaca aaatctggat
     2221 aaaccttaca ctcttcacaa ttattttgta agtaccttaa atgagtttct attttatcta
     2281 cagctatcaa atccatttta tttcctagta aaagtactac atcctcaaga gtaatcgtaa
     2341 caaactccat agcatccaaa agcaaactca accttttagc tccttcttct gtatttatat
     2401 aatcatcatc atattcagaa aaaagtgtta tatatgttcc cttgccatta attgttttag
     2461 caattcccaa ttcatttagc tcattatagg cacttctaac tgttggaaga gatacattat
     2521 atctattaat tatcgaagta attgatggta gacaatctcc tattttaata ttgccttcaa
     2581 aaatttgaca aattacatct gaaacaatta agtcatataa ataacatttt tccaacgtta
     2641 cagaattaaa actacttgta tctatacttt gtggagcacg attttctacc attttaagta
     2701 tggattctct acaagcttta tacatatatg ttaatagttt tttaaattca attagattcc
     2761 cgtccaatcc atataagtaa gtttttctta cctgctctat gtatttatta cgaaaaaagt
     2821 ctatacaaca attatccaag ttatccaagt tatcgaaatt ataggccaat tgtgaaataa
     2881 tgacatcatg ctgaataatc tcacaaaaat ggtgaatcag gaaattattt gttttactta
     2941 ttagtttatt tatatatttt agcctttgtt ctttaaagac taaataatta gaactatttt
     3001 tttccataca atcgataatc tcgtttaatt cttcaaagtc tttagatgta aatcttttaa
     3061 tattgtacat agcaatagaa ggaaatatta aactaaaaat cttatatatt tctgatattt
     3121 gtaaaatctt ctcatataat aagtcagatt ctattgattg tttactcgta ctctggatta
     3181 aaactggtct agaaccagct tttgtctcta taaagccctt ttctgagagc atttttatta
     3241 cagtttttat agtatttttt gataccatat attcttctga catgcttttt atagaatcaa
     3301 gcctatctcc aatagtaatt ttaccagtat aaatttgttg aattatatgc tcaaaaataa
     3361 ttaaatattg tggttttctc ttcatatttt tcctcttcga taaattagat ttattgtttt
     3421 ttgtaaggta tatttacttt tatttaatag ggcaaaatag ttgcttattt tttcctcata
     3481 atctataatt aatatagacc atttatatat atggtctaag ttttataata ctgtaatgca
     3541 gtaaaatagc atattgtagc tatactacag caaattaaca taccattgta gtatattaat
     3601 tggaataatt ttaagtactt caaaattcca gcaaaacata tatgtgtttt tgatattatg
     3661 tatattcgtt aatagaatag ctatacttgt tttacataat aaattatatg atacttgcta
     3721 tatgtaatta ctatatttaa tacacataac tattata
//
LOCUS       DAEPID010000159         3718 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.162, whole genome shotgun sequence.
ACCESSION   DAEPID010000159 DAEPID010000000
VERSION     DAEPID010000159.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 3718)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3718)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3718
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.162"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            293..670
                     /locus_tag="KR257_003739"
     CDS             293..670
                     /locus_tag="KR257_003739"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416765.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="BlaI/MecI/CopY family transcriptional regulator"
                     /protein_id="HBH0032391.1"
                     /translation="MMIRKIPQAELKVMKFIWKVDVTVTSKDVIEAMEQKYGWKQTTT
                     LTLLSRLVKRGFLDAQKIDRYTHYTIRVKHKDYLSFETKDFLSNIHDDSLRSLISALH
                     DDENIGKDKLDFLESYFDNLKDE"
     gene            663..1811
                     /locus_tag="KR257_003740"
     CDS             663..1811
                     /locus_tag="KR257_003740"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454686.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="protease"
                     /protein_id="HBH0032392.1"
                     /translation="MNNYMLYVFENLIKTTIVCSLGICLLLFLKRYLFKKFSKRFNYY
                     IWLIIVFRMLLFLFNYTIVYEVKEPKENALGNNITQIDISTDNNLMLYVAYLWLFVTI
                     VIAVYTFIKYTRFKNLVVDVSYDIEDNDINCIYKNLLKELNIKKKIELRGSDELISPA
                     GMGLFKSYIFLPDYPYSKDELTWILKHELMHFKNKDILIKFLVLSVRIIYWFNPLVYV
                     MSNKVNLDCELCCDESVLVECSLKDKKEYALALIKSIKFSKNYNSKILTTEFDKTNLE
                     KRLESIVKKKGKSGILIAVLVFMTSITSFVEVDAQVRIDEGNNGMNNNINEFLLNKTT
                     DKIINIYYKDAPNEIRKFYEDKCELEGKIPRDYDIIEMDMKDYNQLIK"
     gene            1828..2430
                     /locus_tag="KR257_003741"
     CDS             1828..2430
                     /locus_tag="KR257_003741"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454685.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptidoglycan-binding protein"
                     /protein_id="HBH0032393.1"
                     /translation="MLTKLRKIVAIMCCLLLTFTSVAFADTSKEKGGSKETVPEKNLD
                     SFTLSGYIYTYENAPQEIRDEHKQNCEEINIDPKPDDEIFVPESANLMNEDNSKGVYA
                     SYTVSYNIGAKTITIMSNEYLTISTTKVIRKGNSGKEVKAAQIMLTLLGYNVGIDSSF
                     GSKTYNAVVSFQKKYGLSADGIIGPATWDKLGRLTDPTLS"
     gene            complement(2523..3545)
                     /locus_tag="KR257_003742"
     CDS             complement(2523..3545)
                     /locus_tag="KR257_003742"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903176.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha-hydroxy-acid oxidizing protein"
                     /protein_id="HBH0032394.1"
                     /translation="MDYNDLLKSARENFNGTCKVCKICNGLACAGDVPGMGGKGSGSS
                     FIENRKSLEKIKINMRVIHNVSKPDTSIELFGRKMSSPIFAAPVSGTILNMGGKVSEK
                     EYIEPVVRGCSNSGIYAMVGDTNVDTFLLDNLDVLKDNRGNGIVFIKPWNNSKIIDKI
                     RLSEEAGAFAVGVDLDACGLINNQFQENPFSPKTIDEIRELVESTRLPFIIKGIMTVD
                     DALMAVESGASAIIVSNHGGRVLDYTPGTCEVLPDIAKSVKGKITILVDGGVRTGVDV
                     VKMLGLGADAVLMGRPFVTASFGGGLDGVEFFIEKVRNELCETMILTGCQNVKDIDGR
                     VIWNLL"
BASE COUNT         1449 a          489 c          533 g         1247 t
ORIGIN      
        1 gatattactc tagtttattt taaaaaaaag tattataata ttccttgtgt gaaaatatag
       61 gaatttttat taaatagttt taatgtgtaa ataacattct acactattgt aattaaatat
      121 gtaaaaagta aaatatttaa atagatatat tttaaaatct aacttttaat attgtaaaaa
      181 aattagaaat ttaacaaaaa gtacaaaaat tcacattttt ttcataaagt gtttgactaa
      241 aaaattcaca tgttgtagaa ttaaggtagc aggagttttg agggaggtgt aaataatgat
      301 aagaaaaata ccacaagcag aactaaaagt aatgaaattc atttggaaag tagatgttac
      361 agtgacatca aaagatgtta ttgaagctat ggaacaaaaa tatggctgga aacaaaccac
      421 cacactgaca cttttatcta ggctggtaaa aagaggattc ttagatgctc aaaaaataga
      481 cagatataca cattacacaa taagagtaaa acacaaagat tatttaagtt ttgagacaaa
      541 ggatttccta agtaatatac atgatgactc tttaagaagc ttaatttcag cattacatga
      601 tgatgaaaat ataggtaaag ataagctaga ttttctagaa agttattttg ataatttaaa
      661 ggatgaataa ttatatgcta tatgtttttg aaaatcttat aaagacaact attgtatgta
      721 gtcttggtat ttgtctatta ttatttttga aaagatattt atttaagaag tttagtaaga
      781 gattcaatta ttatatttgg ttgataatag tctttagaat gttacttttt ctatttaatt
      841 atacaatagt gtatgaagta aaagaaccca aagaaaatgc attaggaaat aatattacac
      901 aaattgatat ttctacagat aataatctta tgctgtatgt agcttattta tggttatttg
      961 taactatagt cattgcagtt tatacattta taaagtatac aagatttaaa aatctagttg
     1021 ttgatgtatc ttatgatatt gaagataatg atataaactg tatctacaaa aacttgttaa
     1081 aagaattaaa tataaaaaag aaaattgaat taagaggttc tgatgaattg ataagtccag
     1141 caggtatggg attatttaaa tcttacatat tcttaccaga ctatccttat agtaaagatg
     1201 aactaacttg gattttgaaa catgaattaa tgcattttaa aaataaagat attttaataa
     1261 agtttttagt tttgtctgtt agaataatat attggtttaa tccacttgta tatgtaatga
     1321 gcaataaagt aaatctagat tgtgaattat gttgtgatga aagtgttttg gtagaatgtt
     1381 ctttaaaaga taaaaaagaa tatgcactag cacttataaa gtcaattaag tttagtaaaa
     1441 attataatag taagattttg acaaccgagt ttgataagac aaatttggaa aagagacttg
     1501 agagtattgt taaaaagaaa ggcaaaagtg gaatactaat tgctgtttta gtatttatga
     1561 cttctataac atcttttgtt gaagttgatg ctcaagttag aattgatgag ggtaataatg
     1621 gaatgaataa caatattaat gaatttttat tgaataagac gactgataaa attataaata
     1681 tttattataa agatgcacca aatgaaatta ggaaatttta tgaagataaa tgcgaattag
     1741 aaggtaaaat acctagagac tatgacataa tagaaatgga tatgaaagat tataatcaat
     1801 taataaaata attataagga ggattttatg ttaacaaaat taagaaaaat agtagctatt
     1861 atgtgttgct tattgcttac ttttacaagt gtggcatttg ctgacacaag taaagagaaa
     1921 ggaggaagta aagagactgt tccagagaaa aacctagatt cttttactct ttctgggtat
     1981 atatatacat atgaaaatgc gccacaagaa ataagagatg aacataaaca aaattgtgaa
     2041 gagataaata tagaccctaa gccagatgat gagatatttg ttccagaatc agctaatcta
     2101 atgaatgagg acaatagtaa aggtgtttat gcaagttata ctgtttctta taatataggt
     2161 gctaaaacta taacaattat gagtaatgag tatttgacta taagtacaac aaaagttata
     2221 cgaaagggta atagcggaaa agaagtaaaa gctgcacaaa tcatgttaac tttacttggt
     2281 tataatgtag gtatagatag ttcttttgga agtaagacat ataatgcagt tgtaagtttc
     2341 caaaaaaaat acggtttgtc tgcagatgga ataattggtc cagctacttg ggataaattg
     2401 ggtagactaa ctgaccctac tctttcatag gattaaaatc taaaaatata ttaaatagtg
     2461 tctcaatatg atttttcaat ttaaatgaga cactatttaa atataaatgt tataaaacta
     2521 ttttacaata aattccatat aactctacca tctatatcct taacattttg acaaccagtc
     2581 aaaatcatag tctcacataa ctcattccta accttctcta taaaaaactc cacaccatca
     2641 agaccaccgc caaaagaagc agtaacaaaa ggtcttccca tcaaaacagc atcagcaccc
     2701 aatccaagca tcttaactac atcaacacca gtcctaactc caccatcaac aagtattgtt
     2761 atctttccct ttacagactt agctatatct ggaagtacct cacaagtacc aggagtataa
     2821 tcaagtactc ttccaccatg atttgaaaca ataatggcac tagcaccaga ctctacagcc
     2881 atcaaagcat catctacagt cataattcct tttataataa aaggtaatct agtggattca
     2941 accaattctc taatctcatc aattgtttta ggagaaaaag gattttcttg aaattgatta
     3001 ttaataagtc cacaagcatc aaggtctaca ccaactgcaa aagcacctgc ttcttcagac
     3061 aatctaattt tatctattat ctttgaatta ttccaaggct ttataaatac aattccattt
     3121 cccctattat ccttcaatac atctaaatta tccagtaaaa aagtatctac attagtatcg
     3181 ccaaccatag cataaattcc agaattagaa caacctctaa caacaggctc tatgtattct
     3241 ttttcggaaa ctttaccacc catgttcaat atagtacctg atacaggtgc agcgaatata
     3301 ggagaactca tttttctacc aaataattct atggatgtat ctggctttga aacattatgt
     3361 atgactctca tatttatctt tattttttct agactttttc tattttcaat gaaagacgaa
     3421 ccacttcctt taccacccat accaggaaca tctccagcac aagctaatcc attacaaatt
     3481 ttacatactt tacatgttcc attaaagttc tctctagctg attttagtaa gtcattgtaa
     3541 tccatacaaa atctctcctt tttataatat taaaattgag tattactata ttgaaaatat
     3601 cttaattgta aatataggga tgttattatg atgagctaaa ctagataata catattagat
     3661 attttttatt gttgtagata gttaaattat atcatattag atagtcaaat tttgaaaa
//
LOCUS       DAEPID010000160         3649 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.163, whole genome shotgun sequence.
ACCESSION   DAEPID010000160 DAEPID010000000
VERSION     DAEPID010000160.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 3649)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3649)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3649
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.163"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     repeat_region   14..770
                     /inference="COORDINATES: alignment:crt:1.2"
                     /inference="COORDINATES: alignment:pilercr:v1.02"
                     /rpt_family="CRISPR"
                     /rpt_type=direct
                     /rpt_unit_range=14..42
                     /rpt_unit_seq="atttacattccatatagttaatataaaac"
     gene            complement(1429..3522)
                     /locus_tag="KR257_003743"
     CDS             complement(1429..3522)
                     /locus_tag="KR257_003743"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896470.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="EAL domain-containing protein"
                     /protein_id="HBH0032395.1"
                     /translation="MNKHNFEVILNQLQINIYVTNIHTNEIIFMNKKMKEEYNILDPE
                     GKVCWQVLYPEKNSTCSFCKVLELLKNDKKGVLIKWYEKCNKLNRVFENYDSLITWQD
                     GTVVHMHQSIDIANSTSLNKPIKINEFHEISNNKEEKGVFNFSRDNFDYNSTLLYDAL
                     IRGTDEYIYICNMKTGVFRYSPSQVELFDLPGEIVENPLVYWKKIVHPEDWNRFYKSN
                     TEIGKNQMDYHTVEFRAKNRSGEYIWLRCRGQLMRDEFGEPSIFAGIMTQLGKQNKID
                     SLTQLLNYHEFMSVFEDKISNPMIEKLCIVLLDIDDFKNVNEMYDRDFGDNIIKTLAQ
                     SIQSILPDNAELYKLDGDEMGILVDNVEENEILTLYNQIQNMIIHLQLWRKYGLNITI
                     SAGCVIYPKHGDTVKELYKCASYSLQYAKEHGKNRLVFFSQEILKNKMYSLEMMRDLK
                     ASINDDFRGFSLRFQPQVDTESHKIIGVEVLLRWTNDKCKAISPLEFIPILEENDMIN
                     IVGAWVLRMALRTFRKWIDYYPFFKVSVNVSAVQILEDTFIEDIVKIIDDENFPYQNL
                     VLELTESHTVQNMSILQFKFKALQDLGIYIAMDDFGTGYSSLEVLKFSPIDIVKIDRV
                     FVKDILKSKFDATFIHFIVAICHDVGIKVCLEGVETQEEYDLVKQIKPDYIQGYLFGK
                     PQTATEIFDLLKLDN"
BASE COUNT         1279 a          579 c          350 g         1441 t
ORIGIN      
        1 caacaaaaga tggatttaca ttccatatag ttaatataaa acgatttcaa atgattagaa
       61 taaaaatatc agaattgcta tttatattcc atatagttaa tataaaacta taaagtgtta
      121 cttttattta ttttattttt tacataattt acattccata tagttaatat aaaacgcatt
      181 atatggctgt gtcattttgc attctattac atatttacat tccatatagt taatataaaa
      241 cctgcttaat gcagaattaa gagaggaagt gttataagat ttacattcca tatagttaat
      301 ataaaactgg ttgttcctgc tccggtgttg gtggaactgg tacatttaca ttccatatag
      361 ttaatataaa acgaatatgt atggataatt ttttacttaa catattagca tttacattcc
      421 atatagttaa tataaaacct gctgtaattt ctgatgaagc ttctccacta ccaccattta
      481 cattccatat agttaatata aaacccttct ttaactctta tcgtatttaa acctcttata
      541 acatttacat tccatatagt taatataaaa ctttttgtgt taagaagaaa aaagaaattt
      601 tgataatatt tacattccat atagttaata taaaacctta aagaaaaaat ggaggaagat
      661 taagtgaaaa aattatttac attccatata gttaatataa aactggattt aaataatcaa
      721 aacaactccg gtttaaaaaa catttacatt ccatatagtt aatataaaac cccaaaataa
      781 acttagtatt ttcaacactt acacgtatac aactctctta aatttgcagt gaacgagcaa
      841 tagtgcaatt gataacgctt atcatacact ctcaacgcct tatatttcaa ctgttacgcc
      901 aaattttttc acaaatatcg ctcactgcaa aattcctata attttattat atcataaata
      961 tattactttt gaatattgat accaatttat accataataa aagcaaaaaa acgtaatcta
     1021 tctacattag atttaaattc tataacttaa agttttttac ataatattta tgcttgttta
     1081 atcaatctaa tatatcattc ttgtatattg cttttaatag tcttttttct taaataaata
     1141 tctatctgaa caagcatagt ttaattaaaa acttttgtat tcccttaaaa ctgtatctac
     1201 ctcttattat tttatttatg atatattatt tttaatctaa aaatagatat ctatttttat
     1261 tatggttatc cctttttaaa atactttaat catatactat tcccaattta acatccattg
     1321 aaatgctatt ttcttatatt gcaatttata attgatatat cttcaatata ataatttaat
     1381 gtatttttga ttttaaagct tttcagtgat attattgata aattagaatt aattatctag
     1441 ctttaaaagg tcaaagattt ctgttgctgt ctgcggtttt ccaaataaat atccttgtat
     1501 gtaatctggc tttatttgtt taactaaatc atactcttct tgtgtttcta caccttctaa
     1561 acatactttt attcctacat catgacaaat tgcaacaata aaatgtataa atgtagcatc
     1621 aaacttactc tttaatatat ctttaacaaa tactctatca attttcacta tatctattgg
     1681 agaaaatttt aaaacttcta gagacgagta tccagtacca aaatcatcca tagcaatata
     1741 aattcctaaa tcttgtaaag ccttaaattt aaactgtaaa atactcatat tttgtactgt
     1801 atgactttct gtcaattcta aaacaagatt ttgataagga aaattttcat catctataat
     1861 ttttactata tcttcaataa atgtgtcttc taatatttga acagctgaaa cgtttacact
     1921 cactttaaaa aaaggatagt aatcaatcca tttcctaaaa gtacgtaatg ccattcgaag
     1981 cacccaagcc cctacaatat ttatcatatc attttcttct aatattggaa taaattccaa
     2041 aggagaaatt gctttgcatt tgtcattagt ccaccttaaa agaacttcta cacctattat
     2101 tttatgactt tctgtatcta cttgtggctg gaatcgaaga ctaaaccccc taaaatcatc
     2161 attaattgat gcctttaaat cccgcatcat ttctaatgaa tacattttat tttttaatat
     2221 ttcttgggag aaaaaaacaa gcctgttttt accatgctct ttcgcatatt gtaaagagta
     2281 actagcacac ttataaagtt cttttactgt atctccatgt tttggatata ttacacaacc
     2341 agcagaaatt gttatattta atccatattt tctccatagt tgaaggtgta taatcatatt
     2401 ctgtatttga ttatatagag ttagaatttc attttcttca acattatcaa caagaatgcc
     2461 catttcgtcc ccatcaagtt tataaagttc agcattatct ggtaaaatag attgtataga
     2521 ctgtgctagt gtttttatta tattatctcc aaaatcccta tcatacatct cattaacatt
     2581 tttaaaatcg tcaatatcta ataatactat gcataatttt tcaatcatag gatttgaaat
     2641 tttatcttca aatacactca taaattcatg ataattcagt aactgtgtca atgaatcaat
     2701 cttattttgt ttacctaatt gcgtcattat tcctgcaaaa atacttggtt ctccaaattc
     2761 atcacgcatt agttgacctc tacatcttaa ccatatatat tctccactac gatttttagc
     2821 cctaaattcc actgtatgat aatccatctg gtttttacct atttcagtgt ttgacttata
     2881 aaaacgattc cagtcttctg gatgtacaat ttttttccag taaacaagcg gattttcaac
     2941 aatttctcct ggtaagtcaa ataattcaac ttgtgatggt gaatatcgaa atacgcctgt
     3001 tttcatattg caaatgtata tatattcatc tgtacctcta atcaaagcat cataaagcaa
     3061 tgtagaatta taatcaaaat tgtctcttga aaaattaaaa actccttttt cttctttatt
     3121 atttgatatt tcatgaaatt cattaatctt aattggttta tttaagcttg ttgagtttgc
     3181 aatatctatt gattgatgca tatgaacaac tgtgccatct tgccatgtaa ttaaactatc
     3241 ataattttca aaaacacgat ttaacttatt acatttttca taccacttta ttaatactcc
     3301 ttttttatca ttctttaata attctaaaac tttacaaaaa ctacaagtag aatttttttc
     3361 aggatataat acttgccaac aaacttttcc ttctggatct aaaatattat attcttcttt
     3421 catttttttg ttcataaaaa taatttcatt agtatgaata tttgtaacat atatattaat
     3481 ctgtagttga tttaatataa cttcaaaatt atgtttgttc atatacttat ctcctccata
     3541 gttactgctc tttataacaa cattgttaaa attattcttt ttagaagatt tacttataac
     3601 ttatacatat acactaaata ccttaattta attagaaagt ttattactt
//
LOCUS       DAEPID010000161         3615 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.164, whole genome shotgun sequence.
ACCESSION   DAEPID010000161 DAEPID010000000
VERSION     DAEPID010000161.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 3615)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3615)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3615
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.164"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            complement(251..787)
                     /locus_tag="KR257_003744"
     CDS             complement(251..787)
                     /locus_tag="KR257_003744"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418051.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ParB-like nuclease domain-containing protein"
                     /protein_id="HBH0032396.1"
                     /translation="MEYKSPVYGIIAVPIEKIESNDYNPNAVAPPEMQLLYKSIKEDG
                     YTMPIVCYYNEEKDKYIIVDGFHRYRVMLENEDIYDRENGLLPVSVIDKSLDERMAST
                     IRHNRARGSHNVDLMSKIITELCEIGKSDEWISKHLGMEVDEILRLKQITGLAYLFKD
                     KEFGNAWIPFGSDIEEEN"
     gene            complement(805..2118)
                     /locus_tag="KR257_003745"
     CDS             complement(805..2118)
                     /locus_tag="KR257_003745"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438907.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3440 domain-containing protein"
                     /protein_id="HBH0032397.1"
                     /translation="MDKRYLESDVFEAFQERLSYLFNEFDYIYVSFSGGKDSGLLLNL
                     VLDYKRKNNISSKIGVFHQDFEAQYSLTTEYVEKVFEDNIEDIEPYWVCLPMATRTAV
                     GNYEMYWYPWDDEKEELWVREMPVKEYIINQKNNPFTYYKYKMRQESLAKQFGRWIRD
                     IHEGAKVVCLLGTRAAESLQRYCSIVNKQHGYKGKCWITKEFKNVWTASPIYDWEIED
                     IWLAHYKFDYDYNKIYDLFYKAGVAPRKMRVASPFNDSAKESLNLYRILDPDVWVKLV
                     ARVQGVNFTSIYGKTKAMGYRSVKLPYGHTWKSFTYFLLDTLPENIRNSYIKKFSTSI
                     EFWQNTGGGLSEIVIRELLRKGYKIELNGVSNHTKDKKSRVIFLDDIPDDTDDIKFTK
                     DIPSWKRMCYCILKNDHMCRFMGFGPTKEQRIRTEYIKKKYEKIH"
     gene            2473..2913
                     /locus_tag="KR257_003746"
     CDS             2473..2913
                     /locus_tag="KR257_003746"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888386.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3788 domain-containing protein"
                     /protein_id="HBH0032398.1"
                     /translation="MYERMLDKSNKPCLSQIIEYIGKDGYARLCKLETYLKTQYNLSR
                     ELRFPFGNNYGWGYKYSHKSFHLFYAFFEKGAFTVLIQIGDKQVPAVEKTLVALTPKA
                     KELWVTRYPCGNNGGWIKYRILEDADLLDIIQYIRAKKSPPKQN"
     gene            complement(3098..3286)
                     /locus_tag="KR257_003747"
     CDS             complement(3098..3286)
                     /locus_tag="KR257_003747"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438914.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0032399.1"
                     /translation="MNKNNNLVIICMFIGMILGMAIGCAIGISKGNVGITMCYGLIFG
                     MIIGICIGTVIKNSNKKE"
BASE COUNT         1245 a          620 c          348 g         1402 t
ORIGIN      
        1 gattattttt tattaaaaac gatataaata tacaatttaa tactattttt ttataaataa
       61 acttgtatta aaatacattt agttatataa ttttattttt tctaagagta taattataaa
      121 aataaaaaaa gaataggata attttcctac tcttttttct gtacttacat ataatattaa
      181 aactctttat tttttaatat atattttaaa ttttcttttt taataaatct ttttctttta
      241 ataaatctat ttaattttct tcttctatat cagagccaaa gggaatccat gcattaccaa
      301 actctttatc tttaaataaa taagctaatc cagttatttg cttcaatcta agaatttcat
      361 caacttccat acccaggtgc tttgatatcc attcatcaga ttttccaatt tcacaaagtt
      421 cagttataat tttactcatt aaatccacat tatgagaacc tcttgcacga ttgtgtcgaa
      481 tagtacttgc cattctttca tcaagagatt tatcaattac tgaaacagga agaagtccat
      541 tttctctatc atatatatcc tcattttcaa gcattactct atatctatga aaaccatcta
      601 caataatata cttatccttt tcctcattat aataacagac aattggcatt gtatacccat
      661 cttcttttat acttttatac aacaactgca tttctggtgg ggctactgca tttggattat
      721 agtcgttaga ttctatcttt tcgattggca ctgcgatgat tccatataca ggacttttat
      781 attccatagc atcttaactc ctatctaatg aattttttca tatttcttct taatatattc
      841 cgttctaatt ctctgttctt ttgtaggacc aaatcccata aatctacaca tatggtcatt
      901 ttttaaaata caataacaca ttcttttcca acttggtata tctttggtaa atttaatatc
      961 atccgtatca tcaggtatat catccaaaaa tatgactcta ctctttttat cttttgtatg
     1021 atttgaaact ccatttaatt ctattttata accttttctc aacaattcac gtataactat
     1081 ttctgacaaa ccaccacctg tattctgcca aaactcaata gatgttgaaa attttttaat
     1141 atagctattc cttatatttt caggtaaggt atcaagcaaa aaatatgtga aacttttcca
     1201 tgtgtgtcca tatggcaatt taacactacg atatcccata gcttttgttt tgccataaat
     1261 agaagtaaaa ttaactcctt gtactctagc aaccaatttc acccatacat ctgggtccaa
     1321 tattctgtat aaatttaaac tctcttttgc tgaatcatta aaaggtgatg ccactctcat
     1381 ttttcttgga gctactccag ctttatagaa taagtcataa attttattat agtcatagtc
     1441 aaatttatag tgtgctaacc atatatcttc tatttcccaa tcatatatag gagatgccgt
     1501 ccagacattt ttaaattcct tagttatcca gcactttcct ttatatccat gctgtttatt
     1561 cacaatagaa caataacgtt gtagagattc tgctgctcgt gttcctaata agcaaacaac
     1621 ttttgcacct tcatgtatat ctctaatcca tctaccaaat tgttttgcca aactttcttg
     1681 tctcatttta tatttataat aagtaaaagg attatttttt tgatttatta tgtattcttt
     1741 gactggcatt tcccttaccc ataactcttc tttctcatca tcccatggat accaatacat
     1801 ttcataattt cctacagcag ttcttgtagc cattggtaaa cacacccaat atggttcaat
     1861 atcttcaata ttatcttcaa atactttttc aacatattca gtagtcaaac tatattgagc
     1921 ctcaaaatct tgatgaaata ctcctatttt ggaacttata ttattctttc tcttataatc
     1981 caaaactaaa tttagcagta aaccactatc ttttcctccg ctaaaagata catagatata
     2041 atcaaattca ttaaaaagat aagaaagtct ttcttgaaaa gcttcaaata catcggattc
     2101 taaatatctc ttatccattt gaattatccc ctttcaatta gaagtttata aaaccttaca
     2161 atgcaatatt attatgcttt tttagcagta atcagcataa attatacatt atttaaatac
     2221 acaaatccaa ctaactacat ataattataa tgtaattata cttttgtatt ataaactata
     2281 ttttatcatt attttacatt tttttccaat atatataaat atcatatttt tctattagct
     2341 aaaactaatt actttatatt tctacgtatt agtataataa tacataaaaa cttgaataat
     2401 gcataaaaac ttgacatact gttgtcataa ttactttgct ataattaaaa gtaaaaatgg
     2461 aggtaaattc taatgtatga acgtatgctt gataaaagca ataaaccctg tttgtctcaa
     2521 ataatagaat atataggtaa agatggatat gcacgattgt gtaagttgga aacttacttg
     2581 aaaactcaat ataatttatc aagagaactt cgatttcctt ttggaaacaa ttatggttgg
     2641 ggttacaaat atagccataa atcttttcat ttattttatg ctttttttga aaaaggtgca
     2701 tttactgttc tgattcagat aggtgacaag caagttccag cagtagaaaa aacgttggta
     2761 gctttgacac caaaagctaa agagctctgg gtcactcgtt atccttgtgg caataatgga
     2821 ggctggatta agtatcgtat tttagaagat gcagacttac ttgatattat tcaatatata
     2881 agagcaaaaa aatctccacc taaacaaaat taacttttat tttttgtgat ttaaatatag
     2941 tgtatataaa ttccattctt tccatataaa aaaaataata taaaaaatat ctattagtat
     3001 aacttattta gtatgtctta ttctactttt tacagataat taaaaagttt tatcataaat
     3061 aaatcataac tagacatcct agtaaatcaa aattaattta ttctttttta ttagaatttt
     3121 tgataacagt ccctatacat atgccaatta tcattccaaa aattagacca taacacattg
     3181 tgatacctac atttccttta gaaataccta tagcacaacc tatagccatt ccaagtatca
     3241 tgcctataaa catacatata ataactaaat tgttgttttt attcatagtt ttctccattc
     3301 aatatatttt aaattgccta gctcgccttc ttagcttaaa acaaagaaat ataaattaac
     3361 tttctttcat tctaatatct gcttgtataa atgtcaaaca acacatttct tgtcataacc
     3421 tcctcttttt gaagtaagta caatctccca gacgcaataa tatcaatttc ctaaaaccat
     3481 ttaagtaact tttatattta cataatattt acaatcataa actatatttt tattcattta
     3541 tacatcataa acactcccta ctaatcatta ttatacttaa aataatgttc atttataata
     3601 atatatctaa cacac
//
LOCUS       DAEPID010000162         3551 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.165, whole genome shotgun sequence.
ACCESSION   DAEPID010000162 DAEPID010000000
VERSION     DAEPID010000162.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 3551)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3551)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3551
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.165"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            161..679
                     /locus_tag="KR257_003748"
                     /pseudo
     CDS             161..679
                     /locus_tag="KR257_003748"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888399.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
     gene            1111..1365
                     /locus_tag="KR257_003749"
     CDS             1111..1365
                     /locus_tag="KR257_003749"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454592.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0032400.1"
                     /translation="MENKDIKLTICIFAFVIGIIVLFCCIGLGQFNMDCIIKQNGGSI
                     ATEQYNIYLEQSISQYRNFGSILVLLGGIGILFDKSVRKY"
     gene            1401..1724
                     /locus_tag="KR257_003750"
     CDS             1401..1724
                     /locus_tag="KR257_003750"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897482.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0032401.1"
                     /translation="MARDVFSVKMTPLEAQKMVEKNLEADLVSVDIYNLENNKSIIVT
                     IFEKYYARSNSDAGLVVICENTTGKTLVKITSTGSAIGLFQIDWGTGNNLIKRVKKIF
                     IDYII"
     gene            1998..2150
                     /locus_tag="KR257_003751"
     CDS             1998..2150
                     /locus_tag="KR257_003751"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454589.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0032402.1"
                     /translation="MDNFLFNVLASVTASYIVYLISKLIKKVKSHSTAKSDLKIDINF
                     KYHRKK"
     gene            2344..3267
                     /locus_tag="KR257_003752"
     CDS             2344..3267
                     /locus_tag="KR257_003752"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861517.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SHOCT domain-containing protein"
                     /protein_id="HBH0032403.1"
                     /translation="MVGAFVLPNYAIILSEMSNLWGNFIMWILVPIITIVLLIIAVSS
                     MQYILVMIAFLLIIYSFIEKKIVMGLVSVLFFTYSIYLCATWEDKSLIADNKVETVKA
                     QRETVEREKEMERRRIQEEVDKERYIEKHGMEISENDLKVKLEALVPQEYKGKKYELK
                     VGKFKRYSMYFDLTVQNEKFSNSEECKKFVKEIANDLKKIKISKAYFKFHSKDDGGIY
                     NSVYIDYFRNIQNNVDNVENLEFNEFELKTEEEEKREQEKIEQEKNSYNNYIQNRVVD
                     PLDRIKKLKELLDSGAITQEEYNKKKKELLE"
BASE COUNT         1487 a          330 c          611 g         1123 t
ORIGIN      
        1 tttaatagaa tatgtatagt atatagtaga tagaatgtat aaaaataaaa actgttcaat
       61 aagaattaat atacattaat tcagctgaat ccaatcaaaa tacttaaata aaagtaatct
      121 gaaaataaca taattcaaat caatttattc aaataaacct caatttatct caaatcttaa
      181 gaagtcatta aacaaacttg ctaaattaca aagagaatta tcaagaaaaa caatcggtag
      241 tttaaataga aataaagcaa gattaaaagt tgcaagactt caagaacata tagctaatca
      301 aagaaatgat tttctacaaa aactatctac taaattaata aaagagaacg atattatttg
      361 catagaagat ttacaagtaa agaatatgat taggaatcgt aaactatctc gctcaatttc
      421 tgatgtgtca tggtcagagt ttattcgtca attagaatac aaggctaatt ggcatggtag
      481 acaaattgta aaggtgggta aattctttgc aagttcacaa atatgcaata aatgtgggta
      541 taaaaacgag gaagtgaagg acttaaatat aagagaatgg atttatccta gttgtaatga
      601 aactcacgat agagatataa atgcaagtat aaatatatta aaagaaggat taagactaat
      661 aacaattcaa aataaataac gtatgtaaga accgtaggaa ctacggggat agcctgtgga
      721 gaattagtaa gacatatgtt agtatgcaaa attctgtgaa gcaggaaacc tgtgacttta
      781 gtcatgggag gttcaggcta gtattactca ttattgtatt caaaagctaa agtggaaacc
      841 tagtgaatat atgaatttag aagttaatga gagagcatta gcagccgact caatacttat
      901 taaaattgaa gatgaagaag aaacaatgaa agaagctgaa agagagaaaa agagaggtag
      961 aagaaggtag aatttaaagt taaaatagtt acattgctaa tatatgaaaa tgttacaaat
     1021 ttggaaatag atggatatat atgttgtata gtataatgta gataatatat caccaagtaa
     1081 aaaacaacaa ataaatctaa attatgaggg gtggaaaata aagatattaa acttacaata
     1141 tgtatatttg cttttgtaat tggaataata gtgttatttt gctgtatagg tctaggtcaa
     1201 tttaatatgg attgtattat aaaacaaaat ggtgggtcaa tagctaccga acaatacaac
     1261 atatatttag aacaatctat ttcacaatat agaaattttg gttctatact ggttttacta
     1321 ggaggaatag gaatactgtt tgataaaagt gtcagaaaat actaaaaaag tatattttta
     1381 tttaggatgt gatgaatgat atggcaagag atgtatttag tgtaaagatg acaccactag
     1441 aagcacagaa aatggtagaa aaaaatttgg aagcagattt agtttctgtt gatatttata
     1501 acctagaaaa taataagtct ataatagtta caatctttga aaaatattat gcaagaagca
     1561 atagtgatgc aggtttggta gtgatttgtg aaaatactac aggaaaaaca cttgttaaaa
     1621 ttacctcaac tggtagtgca attggactat ttcagattga ttggggaaca ggtaataatt
     1681 tgattaaaag agtaaaaaaa atatttattg attatattat ttaattattt tatgtagata
     1741 ttcttaggtt ggtatggaat ttgtactaac ctattaagta atcaataaaa ctaaataaac
     1801 atagaaagca cttacaaata tgtaggtgct ttttattgaa aaaatagaaa ataaaataaa
     1861 aagtaagata taggaaaaat atgtaagaat tatatgttat aataattgta gcaagaagat
     1921 gtaatctaca atttatagag tggagttcat gtattaaaaa attatcctcc caacgataag
     1981 aagggaggtg aatatacatg gataattttt tatttaatgt gttagctagt gtaacagcta
     2041 gttacatagt ttatttgatt agcaagttaa tcaaaaaagt aaaaagccac tctaccgcaa
     2101 agagtgactt aaagattgat ataaatttta aatatcatcg taaaaaataa ctttcagtta
     2161 tagaacttca ctctaccgca aatagattgt agttcttctt gtttttatta taccacaaat
     2221 tagaaaaaat attgcatata atatttttta tagtcaataa aaatatgaaa ttttttatac
     2281 acaatgatga tgaatctaac tagatgaata aatttaattg taaataagaa agtacttact
     2341 taaatggtag gtgcttttgt tttgccaaat tatgctataa tattgagtga gatgagtaat
     2401 ttgtggggga attttataat gtggatatta gtaccaataa taacaatagt attacttata
     2461 atagctgttt cttctatgca atatatttta gttatgatag cttttttgtt gattatatat
     2521 tcttttatag aaaagaaaat agttatgggt cttgtgtcag ttcttttttt cacttattca
     2581 atttatcttt gtgcaacttg ggaagataaa tccttgatag cagataataa agttgagact
     2641 gttaaggcac aaagagaaac tgtagaaaga gaaaaagaaa tggaaagaag aagaatacaa
     2701 gaagaagtag acaaagaaag atatattgaa aaacatggaa tggaaatatc agaaaatgat
     2761 ttaaaagtta agctagaggc tttagtacct caagaatata aggggaagaa atatgaatta
     2821 aaagtaggaa aatttaaaag atatagtatg tattttgatt taactgtaca aaatgaaaaa
     2881 tttagtaatt ctgaagaatg taaaaaattt gtaaaagaaa ttgctaatga tcttaaaaaa
     2941 attaaaataa gcaaggcgta ctttaagttt cattcaaaag atgacggcgg tatatataat
     3001 tctgtttata ttgattattt tagaaacata caaaataatg tagataatgt tgaaaattta
     3061 gaattcaatg agtttgaact taaaaccgaa gaagaagaga agcgagaaca agagaaaata
     3121 gaacaagaaa aaaacagtta taataactac attcaaaaca gagtggttga cccactagat
     3181 agaataaaga aactaaaaga gttgctagat tcaggagcaa ttacacagga agaatataat
     3241 aaaaagaaaa aagaattatt agaatagata atatagtaag cacttacaag tatgtaggtg
     3301 cttttaaatt tacaaagtat tccattttaa ttttatagtt tagattttat gatataataa
     3361 aaatatagaa gttttgcagt gtgcgatatt tgttacaaag tagggcttaa tacttgaaat
     3421 ctaagatgtt gagggtgcgt gataagtgtt atcaattgca ctattgcccg ctcactgcaa
     3481 ttttaagagt attgtatata tgtaggtatt ggaaatgcta agtttatttt ggggttttag
     3541 attaactata t
//
LOCUS       DAEPID010000163         3373 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.166, whole genome shotgun sequence.
ACCESSION   DAEPID010000163 DAEPID010000000
VERSION     DAEPID010000163.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 3373)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3373)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3373
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.166"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            complement(93..458)
                     /locus_tag="KR257_003753"
                     /pseudo
     CDS             complement(93..458)
                     /locus_tag="KR257_003753"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423610.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="ROK family protein"
     gene            complement(479..1558)
                     /locus_tag="KR257_003754"
     CDS             complement(479..1558)
                     /locus_tag="KR257_003754"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420406.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF917 domain-containing protein"
                     /protein_id="HBH0032404.1"
                     /translation="MRFLTEESVDKIAVGAAVLGTGGGGDPYVGKLVAKQAIKKYGPV
                     KVISLDELDDDALVVPVSGMGSPVITIEKLLSEVELTTPLEIMEKLLNRKVDVIIPIE
                     IGGINSLMPIAVAAKKGLPILDADSMGRAFPEAQMVTFYLEGYEASPAVMSDEKGNSA
                     ILYPVDGIWSERLARTLTVEMGGSSSISDYNLSGAQVKKAAIGNTLTIAETIGGFLLE
                     NKSDSKGAVENILKELRGYKLFEGKVIDIKRELKGGFTRGHAFFAGINEYDGEYSILF
                     QNENLIAKKGDTPLCITPDLIAVLDLETGFPITTERIKYGSRVMVVAFPCNEKWRTEK
                     GIETVGPGYFGYDVEYKTVEELQGK"
     gene            complement(1612..2901)
                     /locus_tag="KR257_003755"
     CDS             complement(1612..2901)
                     /locus_tag="KR257_003755"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896853.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cytosine permease"
                     /protein_id="HBH0032405.1"
                     /translation="MEEEKINYALEQIPENQKRGWVAMFSVLVAIGVDLSSVILGAEL
                     AQSMPMKQAILSVIVGSFFSAILYTTCSLVGSSTSLSTSMITKYVFGEAGAKIFSLVI
                     GVSLLGWFGVQVGFFAQNAQIIIKDIFNLDVSMQILSLIGGLLMMSTAIYGYKAMEKL
                     SVYSVPFLLVLMMLTIFLAFRANGISVDDNMKSTMTFAGGVSLSMSIIIVGAIVSPDI
                     SRWAKSRRDCALSSFLGIQFGNAFMIIVSIVLVKCMGTSDIMRIFITLGIAIPGIIVL
                     TLAQWTTNTSNVYSASLSIALVLKKAPEKVLTIVLGIIATLLAVFGIYEGFIGFLNLL
                     GIVIAPVGGVYTAEYYIVKQELKGFDKGVLYKPIVKRSIVSWIIGILITYLSTYGFIT
                     LTTIAPLDGFIAGFVVQSIIGKVLCSTKNKQEIDKAV"
     misc_binding    complement(3064..3275)
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00230"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="T-box leader; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /bound_moiety="tRNA"
                     /db_xref="RFAM:RF00230"
BASE COUNT         1110 a          678 c          371 g         1214 t
ORIGIN      
        1 tatcctatct ctacatatag gtttccctat atgctgacta ttttagctac taactcatga
       61 ctaaagtcac gagtgtgcgt agctattttt taatcaaact catatccacc agataccaat
      121 attgaatcta attctatttt ttctcttaag tcttctggcc aatctataaa tggaagaatg
      181 gcagtagtgg ctggctttcc tattcttatc atagccacat tattaagtct ttttctttct
      241 acaatagcat ttgtacaatg agttgtacca agcatagcat attttattaa tgaatggtca
      301 atcttacttt catctataac tttttttaag gcattgtaaa caccagtttc aacatctttt
      361 gtagttgcca ccttaactga atgaattact tttaattccc catccagtat acaagcatct
      421 gtatttgttc ctccaacgtc aattcctaca cgatacatca aaatttcctc ctaaactttt
      481 attttccttg taattcttct actgttttat attccacatc atatccaaag tatccaggtc
      541 caactgtctc aattcctttt tctgttctcc atttttcatt acaaggaaaa gctactacca
      601 taacacgaga gccatatttt attctctctg tagttattgg aaatccagtt tctaaatcta
      661 atactgctat taaatctggt gtaatacaaa gtggtgtatc accttttttg gcaattaaat
      721 tctcattttg gaataatata gaatactctc catcatactc attaatccca gcaaaaaagg
      781 catgtcctct agtaaatcca cctttcaact ctctcttaat atcaattact tttccttcaa
      841 ataacttgta tccacgcaat tcttttagta tattctcaac agcacctttt gaatcagatt
      901 tattttcaag taaaaaccct cctatagttt cagctattgt aagagtatta cctatagcag
      961 cttttttaac ttgagctcca cttaaattat agtcactaat agaagaactt cctcccattt
     1021 ctacagttaa agttctagct aatctttctg accaaattcc atccacagga taaaggatgg
     1081 cagaattacc tttttcatca gacattacgg caggagatgc ctcatatcct tcaagataaa
     1141 aagttaccat ttgagcttca gggaaagctc tacccataga atctgcatct aagataggaa
     1201 gtcctttttt agcagcaact gctataggca taagtgagtt tatccctcct atttctatag
     1261 gaattataac atccactttt ctatttaata atttctccat tatttctaaa ggggtagtta
     1321 actcaacttc tgaaagtaat ttttctattg taattacagg agaacccata ccagatactg
     1381 gaactaccaa agcatcatca tcaagttcat ctaaacttat tacttttaca ggaccatact
     1441 ttttaatggc ttgttttgca accaatttac ctacatatgg gtcacctcca cctccagttc
     1501 caagcactgc tgcaccaact gctattttat ctacactttc ttctgttaaa aatctcatgt
     1561 tactttctcc tcatatttct aatttatttt atactttata aacaaatttc tttatactgc
     1621 tttgtctatt tcttgcttat tttttgttga acaaagcact tttccaataa tagattgtac
     1681 tacaaaccct gctataaaac catctaaagg tgctatagta gtaagagtta taaatccata
     1741 tgttgaaagg taagttatta atataccaat tatccaagac actattgaac gtttaactat
     1801 tggtttatat aatactcctt tatcaaagcc tttaagttct tgctttacta tgtaatattc
     1861 tgctgtatat acaccaccaa caggtgcaat tacaattcca agtaaattta aaaatcctat
     1921 aaaaccttca tatattccaa atacagccaa taatgttgct ataataccaa ggactatagt
     1981 taatactttc tcaggagcct tcttaagtac aagagctata cttaatgatg ctgaatatac
     2041 attacttgta tttgtagtcc attgtgctaa tgtaagtact attatacctg gtatagcaat
     2101 tcctaatgta ataaaaattc tcataatatc tgaagttccc atacatttta ctaatactat
     2161 cgaaactatt atcataaaag catttccaaa ttgtattccc aaaaagcttg aaagagcaca
     2221 gtctcttcta cttttagccc aacgacttat atcaggagat acaattgcac caactattat
     2281 tatactcatt gacagagaaa ctccacctgc aaatgtcata gtagatttca tattatcatc
     2341 aactgaaatt ccatttgctc taaaagctaa gaatatagtt agcatcataa gaactaataa
     2401 aaatggtact gaatacacac tcaacttctc cattgcctta tatccataaa ttgcagtact
     2461 catcatcaag agaccaccta ttaggcttaa aatctgcata cttacatcta aattaaatat
     2521 atcttttatt attatctgtg cattttgagc aaagaaacct acttgaactc caaaccaacc
     2581 taatagagaa acccctataa ctagagaaaa tatttttgct ccagcttctc caaatacata
     2641 ctttgttatc atagatgtag ataaacttgt agatgagcca accaaagagc atgtagtata
     2701 caaaattgca gaaaaaaatg aaccaacaat tactgacaat attgcttgtt tcattggcat
     2761 actctgtgcc aactcagcgc ctaaaataac agatgataaa tccacaccta ttgctactaa
     2821 aactgaaaac atagctaccc aaccacgttt ttgattctct ggaatctgtt ccagagcata
     2881 gttaattttt tcttcttcca ttttcatccc tccatttaaa tcgtaaaact actgacctta
     2941 gcatatttta caattttcta atttataaat ttattaacta tcatattttt ataattttca
     3001 tttaatatat agttttaaat tttctgaaat aagtttataa taaaaaacgc ctcttggaaa
     3061 aatccaagag acgaatataa atccgtgtta ccactcttat tagtaaaaat taattttact
     3121 cactcatttt cttaaggcga attaaaccac tattctaaca taattacaat agtattctcc
     3181 aaagtccttt tcacataaat tccaatatta gttctcagcc aaatctaact ctctgtaaaa
     3241 ttcctttatg ctactttctt cttctacgaa tatataatat tgatttgtag ttaatttatg
     3301 atttatatca taatatatat gcaatatttt gtcaacttaa aaagtcaatt acttgcattt
     3361 tttagtttta tat
//
LOCUS       DAEPID010000164         3157 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.168, whole genome shotgun sequence.
ACCESSION   DAEPID010000164 DAEPID010000000
VERSION     DAEPID010000164.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 3157)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3157)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3157
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.168"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            complement(<1..1011)
                     /locus_tag="KR257_003756"
     CDS             complement(<1..1011)
                     /locus_tag="KR257_003756"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436722.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBH0032406.1"
                     /translation="MTLFRIAMQNVKNSFFNYLMYFISIVFSVFVFFSFKSIEYNEAL
                     SSLGEKTRMSINTSSIVIVVFVFLFIYYSNSFFFNRRRREVGTYSLLGMRKNQIGKIF
                     LYETFLMGIVAILIGIFLGLLFSKLMTMMLVKLMNEMIVVNMNLSIKALVQTLAVFLI
                     IFIVIGIRNTIVIRNKRIIELFNKYPEKYKFKKFIKLKCVLGVLLIAISYLMSISYFI
                     AENIMLSVFILVTIIPGTFLFFSSTMYMIIDAVKKRKSFYYKGQNLIAFSELGFKLKS
                     NSSVLAVIAILIATSVTMLGFTISLYYDIDRNISENYKYSYTINLGNSYVNNEIDKLL
                     YKY"
     gene            complement(998..1765)
                     /locus_tag="KR257_003757"
     CDS             complement(998..1765)
                     /locus_tag="KR257_003757"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003722224.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBH0032407.1"
                     /translation="MEEILSVENIKKEYGRKGSKHEALRGITFKVYKGEFVGIMGSSG
                     AGKSTLLNIISTIDLPSSGDIYINGKNTIKMKQNELADFRRDNLGFVFQDSNLLDTLT
                     IKENIMLPLSLKNERVSVIENRIKEISKELNIESILDKYPGEVSGGQKQRGAVCRAIA
                     TKPSLVLADEPTGALDSKSARDLLNCLLKLNKDSNKTILMVTHDAISASFCNRILFIK
                     DGIIFTEIVKGESNREFYNKIVNTVSLIGGVNKNDFI"
     gene            2053..2727
                     /locus_tag="KR257_003758"
     CDS             2053..2727
                     /locus_tag="KR257_003758"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429757.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HBH0032408.1"
                     /translation="MFKIMVVEDDVSLKNIIAKCLTKWGHDVHQIENLENIIEEFKNY
                     NPELVLLDINLPFYDGFHWCNEIRKISKVPIIFISSRNSNMDVIMGVNLGADDYIQKP
                     FSVDVLVAKVNALLRRTYNFVDNNSNQIIHNGVTLDLSTATINYEDNTIELTKNEIKI
                     LHELMKYKGQIVSRNKLMKKLWDNDWFVDDNTLTVNVNRIRSKLNEIGLEDFIETKRG
                     LGYIIS"
     gene            2751..>3157
                     /locus_tag="KR257_003759"
     CDS             2751..>3157
                     /locus_tag="KR257_003759"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728538.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sensor histidine kinase"
                     /protein_id="HBH0032409.1"
                     /translation="MSFKDFLKDKLGFLVYNFTFLIFTVSVIIFSPVDVFLTDTILYI
                     LVVNVVFLFLYLFISYIKKNKFLDKIKNDTFKINMNDIELARCKNEEKIYLNIIKNHQ
                     YQCNNIINNNIEKFEENKEILNMWVHDVKIPIA"
BASE COUNT         1187 a          422 c          352 g         1196 t
ORIGIN      
        1 atatttatat aataatttgt caatttcgtt atttacataa gaatttccta aatttatggt
       61 ataactgtat ttataatttt cacttatgtt cctatctata tcgtaataaa gtgatatggt
      121 aaaccctagc atagttacac ttgtagctat taatattgct attacagcca atacactact
      181 attgctcttt aatttaaatc caagttcaga aaatgcaatt aaattctgtc ccttataata
      241 aaaacttttt ctcttcttaa cagcatcaat aatcatatac atagttgatg aaaaaaataa
      301 aaaagttcca ggtattattg taactaatat aaaaactgaa agcataatat tttcagcaat
      361 aaaataacta attgacatta aataagaaat agctattaat aaaacaccaa gtacacattt
      421 taactttata aattttttaa acttatactt ttctggatat ttattaaata actctataat
      481 tctcttattt ctgataacta tagtatttct tattccaata actatgaata ttattaaaaa
      541 taccgctagt gtctgaacta aggcctttat acttaagttc atatttacta ctatcatttc
      601 attcattaat tttacaagca tcatagtcat aagctttgaa aataacagtc ctaaaaatat
      661 acctattagt attgcaacta tacccatcaa aaaagtttca tataaaaata tttttcctat
      721 ctgatttttc ctcattccaa gtaaactata agttcctact tctcgcctac gtctattgaa
      781 aaaaaatgag tttgaataat atataaataa aaatacaaat accactatta caattgaact
      841 tgtattaata ctcatcctag ttttctctcc aagtgaactc aacgcttcat tatactctat
      901 agatttaaaa ctaaaaaata caaatacact aaatacaatt gaaataaagt acattaaata
      961 attaaaaaaa ctattcttta cattttgcat tgcaattcta aataaagtca tttttattaa
     1021 ctcctccaat taaggaaact gtatttacta ttttattata gaactctctg ttactttctc
     1081 cctttacaat ttctgtgaat attattccat cctttataaa gagtattcta ttgcaaaaac
     1141 tcgcacttat agcatcatga gttaccatca atattgtttt attgctgtct ttgtttaatt
     1201 ttaatagaca attcaacaaa tccctagcag atttagaatc taatgctcct gtaggctcat
     1261 ctgcaagtac taatgatggt tttgttgcta tagctctaca tacagctcct ctttgctttt
     1321 gtccaccaga aacttcgcca gggtatttat ctaatataga ttctatattt aattcttttg
     1381 aaatctcttt tattctattt tctattactg atactctttc attttttaaa gaaagaggca
     1441 acattatatt ttcttttatt gtaagtgtat ccaaaagatt agaatcttga aatacaaagc
     1501 ctagattatc acgtctaaaa tctgccaatt cattttgctt cattttaata gtattctttc
     1561 catttatata aatatctcct gatgaaggta aatctattgt agaaataata tttaaaagtg
     1621 ttgatttacc agcaccggaa gaccccataa taccaacaaa ttctccttta taaaccttga
     1681 aagttattcc tcttagagct tcatgttttg aaccttttct tccatactcc ttttttatat
     1741 tttcaacaga taatatttct tccatagtta ataatcacct ttcatcacaa ttagttattt
     1801 atcaattctc acaaatatat tatatatatt aaaatggctt ttaaacattt aattatatta
     1861 atttaaggtt acattttcgt aagtattaat tatatttctt caaatttatt gcaattatgt
     1921 ttaaaatata atttatcaag taaaatatag ttatattaat ataattattt taggtaataa
     1981 ggtagaaata ttttaattta tcaagtagaa tatagttatg ttaatataac tattttgaat
     2041 taggaggtaa gaatgtttaa aataatggta gttgaagatg acgtctcatt gaaaaatatc
     2101 atagcaaagt gtcttactaa atggggacat gatgttcatc aaatagaaaa tcttgaaaat
     2161 ataatagaag agttcaaaaa ctataaccca gaattagttt tattggacat aaaccttcca
     2221 ttttatgatg gttttcattg gtgtaatgaa ataagaaaaa tttcaaaagt tcctataatt
     2281 tttatttctt caagaaattc taatatggat gtaataatgg gtgtaaattt aggtgcagat
     2341 gattatatac aaaaaccttt ttctgtagat gtcttagtag ctaaagttaa tgccctttta
     2401 agaagaactt ataattttgt tgataataac tcaaatcaga ttattcacaa tggtgttact
     2461 ttagatttat caactgcaac aataaactat gaagataata ctattgagct aacaaaaaat
     2521 gaaatcaaaa ttctccatga gcttatgaaa tataaggggc agatagtaag taggaataaa
     2581 ctcatgaaaa aattatggga taatgattgg tttgtagatg ataatacatt aactgtcaat
     2641 gtaaatagaa tacgctcaaa attaaatgaa attggtttag aagattttat agaaacaaaa
     2701 agaggattgg gttatataat cagttaaaac aattctaagt aggtgaattt atgagcttta
     2761 aagattttct caaggataaa ctaggttttt tagtatacaa ttttactttc ttaattttta
     2821 cagtatcagt tattatattt tctcctgtag atgtttttct gactgatact attttatata
     2881 tattagttgt aaatgttgtg tttttatttt tatatctatt tattagctac atcaagaaga
     2941 acaaattttt ggataagata aaaaatgata cattcaaaat taatatgaat gatatagaat
     3001 tagctagatg taaaaatgaa gaaaaaatat acttgaacat tattaaaaat catcaatatc
     3061 aatgtaataa cataataaat aataatatcg agaaatttga agaaaacaaa gagattttaa
     3121 atatgtgggt acatgatgta aagataccta tagctat
//
LOCUS       DAEPID010000165         2946 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.169, whole genome shotgun sequence.
ACCESSION   DAEPID010000165 DAEPID010000000
VERSION     DAEPID010000165.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 2946)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2946)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2946
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.169"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            223..1494
                     /locus_tag="KR257_003760"
     CDS             223..1494
                     /locus_tag="KR257_003760"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889556.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amidohydrolase family protein"
                     /protein_id="HBH0032410.1"
                     /translation="MLKVLKGNIIFTKTSETFTVFENSYIILEKGKVKGIFKEIPKEY
                     KNLKVVDYTDKLIIPGMNDLHAHASQFKNLGMAMDKELLPWLETYTFPEESNYKDIEY
                     ATKMYKKFVKELWKSGTTRIAVFATVHKEASMKLMDIFKEVGLGAYVGKVNMNMNCPD
                     TLLENTQDSITDTEEIINKYSDTDSIVKPIITPRFIPSCTSELLKGLGDLCLKYNIPI
                     QSHLSENYDEIEWVRSLEPESKFYGDAYNRYNLFGQTPTLMAHCVHCSQDEIDLMREN
                     NVMAVHCPASNFNVGSGAMPIRKLIDNNIRLALGSDISGGHTLSIFKAMVSAIQLSKL
                     YWVNSGKKYNFLSLSEAFYIATKSGGSFFGKVGSFEEGYDFDALIIDDSNLNHDNYSI
                     LERLERFIYVGDDRNIIHRYVCGKLIEEPNI"
     gene            complement(2134..2889)
                     /locus_tag="KR257_003761"
     CDS             complement(2134..2889)
                     /locus_tag="KR257_003761"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889555.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1835 domain-containing protein"
                     /protein_id="HBH0032411.1"
                     /translation="MAHICFEDICYLLLKEAMKLKLIPHNKIVLFEDDLSIGNIFDVN
                     NYELRENIFKIRNVFENNPKLLFKPDLLEDRKLSKCRNIIIWCANNPKDLCGVYYVVS
                     KFQDKNIKIALVDEKKTEDALIRYSFTSEMSPEDFPFFLDKTLEIGFNEKLEFKNKWD
                     VLVKENSIFRALVGNEIKSVEETYFDKYILRNISDKWQPLIEVVANCMFEDEMRVKDW
                     FILWRLEKMASLKIVKIKGSKGDFYSDKEIRKV"
BASE COUNT         1092 a          386 c          343 g         1125 t
ORIGIN      
        1 taacattcca ttttatgtaa gtaggcatta tatttttctt aaatgtcact taaatgtcag
       61 ttatatataa taatagtaaa caactgtatt tcactaatat ttgctattat ctaatagtat
      121 ttatagttta gatttgatat aatacatgtg gtaaaatttt gatttgtaaa acaaaatttt
      181 acctacatat attaaaacaa atttaaaact aaggagacct atatgttaaa agtattaaaa
      241 ggaaatataa tttttacaaa aacttcagaa actttcacag tatttgaaaa tagttatatt
      301 atactggaaa aaggtaaagt aaagggaata tttaaagaga tacctaagga atacaaaaac
      361 ctaaaagtag tagattacac tgataagctt ataatacctg gtatgaatga cctccatgcc
      421 catgcctctc aatttaaaaa tcttggaatg gctatggata aagagctttt gccatggctt
      481 gaaacttata catttccaga agaatcaaat tataaagata tagaatatgc aacaaaaatg
      541 tataaaaaat ttgtaaaaga actttggaaa tctggaacta caagaatagc agtgtttgca
      601 acagtacata aagaagcctc tatgaaactt atggatatat tcaaagaagt tggtcttgga
      661 gcatacgttg gtaaagtaaa tatgaatatg aattgccctg atactttatt agaaaacact
      721 caggattcta ttactgatac agaagaaatt ataaataagt atagtgatac agattctatt
      781 gtaaaaccaa taataacacc tagatttata ccaagctgta caagtgaact tttaaaaggt
      841 ttaggagatt tatgtttaaa atataatatt cctattcaat cacacttatc tgaaaattat
      901 gatgagattg aatgggttag aagtctagaa cctgaatcta aattctatgg agatgcatat
      961 aatagatata atttatttgg tcaaactcct actttaatgg ctcattgtgt tcattgttct
     1021 caggatgaaa tagatttaat gagagaaaat aatgttatgg cagttcactg tccagcttct
     1081 aactttaatg ttggtagtgg tgctatgcct atcagaaaat taatcgataa taatattaga
     1141 ttagcacttg gatcagatat aagcggtgga catacattgt caatatttaa agcaatggta
     1201 tctgcaatac aattatctaa attatattgg gttaattctg gtaagaagta taatttctta
     1261 tctttatctg aggcttttta tattgcaacc aaaagtggtg gaagtttctt tggaaaagtt
     1321 ggtagctttg aagaaggtta tgattttgat gcattgatta ttgatgattc aaatttaaat
     1381 catgacaatt attctatact tgaaagactt gaaagattta tctatgttgg tgatgataga
     1441 aatatcattc atagatatgt atgtggaaaa ctaattgaag aacctaatat ataattataa
     1501 taaaaatttt aattatatat tatggttaat ttatacaact ataattaata aaagagtata
     1561 ttttaaatct aaaagctata ggttgaaaca tactcttttt attttgttta tttatagctt
     1621 tagttattaa tcatatataa atctacaaaa cgtattccta gtaacttata ttttttgata
     1681 tctacaatca taagactata ttattggatt catacctcaa aaatattgcc ttctgaacat
     1741 tattatattc aaagctatgt taatttacaa tgatatatcc taacatgtat tgattaaaaa
     1801 aaattaaaac ttgcttttca tctcctatat ctaaagaagt ggtatttaga ataaactatt
     1861 gtaatattaa agttgaaatt ttctagttta tttactctat agcaccatat tttaatacta
     1921 ttaagtaaaa atgtagttaa aatatatact aatatccctg aaataagtat ttctttttta
     1981 tttagcacac ttattcgtaa ggtattagtt attatatttc caaattatag aataaatatt
     2041 atacttattg ctaattataa tattaatact gttaagatat ttttcttcat agttataccc
     2101 attatttaat acaatttatt ataaattcaa tttttaaact tttcttatct ccttatcaga
     2161 ataaaaatcc cctttacttc cttttatttt tactattttt aaacttgcca tcttctctaa
     2221 tctccaaagt ataaaccaat cttttacacg catttcatct tcaaacatac agtttgcaac
     2281 cacttcaatt aaaggttgcc atttgtcact gatatttctt aatatatatt tatcaaaata
     2341 agtttcttca acacttttaa tttcgttacc tactaatgct ctaaaaatag aattttcttt
     2401 aactaacaca tcccatttat ttttaaattc tagtttttca ttaaagccaa tttctagtgt
     2461 cttatctaaa aagaatggaa aatcttctgg agacatttca ctggtaaatg aatatctaat
     2521 tagagcatct tctgtctttt tttcatctac taatgcaatc tttatatttt tatcttgaaa
     2581 cttactcact acataatata ctccacacaa atcttttggg ttatttgcac accatattat
     2641 tatatttcta cattttgata atttcctatc ttctaacaaa tctggcttga ataatagttt
     2701 cggattattt tcaaaaacat ttctaatctt aaaaatattt tctcttaatt cgtagttatt
     2761 tacatcaaaa atattaccta ttgataaatc atcttcaaat aatacaattt tattatgtgg
     2821 tattaacttt aacttcattg cttcttttaa taacaaataa caaatatcct caaagcatat
     2881 atgtgccata aaattcacct cttttaaaat taacaattta ttttattata atatataaac
     2941 tgtaat
//
LOCUS       DAEPID010000166         2941 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.170, whole genome shotgun sequence.
ACCESSION   DAEPID010000166 DAEPID010000000
VERSION     DAEPID010000166.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 2941)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2941)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2941
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.170"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            <1..1632
                     /locus_tag="KR257_003762"
     CDS             <1..1632
                     /locus_tag="KR257_003762"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729570.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycerophosphodiester phosphodiesterase"
                     /protein_id="HBH0032412.1"
                     /translation="IKVLTNPMSIVLIILSVIILAFYAFFEFTSVIICFNKSIKYEKI
                     GLFELFKISFENSIKLLYPKNILLFIFVILIIPLVNTVLISGFIGKIQIPEYILDYIK
                     SDIILNIIYMIFLLIIYISVIRWIFSIHEITLNTENFKRARKESVNLIKGKIIRTIIY
                     SLILSLVVAIIGYAIYHSGIIFIGIWTKYCTDMEFLKNVFINRCIAFEEYFRLILSIF
                     IFILDIGFISATYYQYKGVNISKNNIKKEKKSISKIVFNLVLILLISYIESVAFSSHI
                     NGMFNTSFSFYTTAIAHRAGAEMAPENTLAAIEEASHAKADYAEIDVQETKDGELIVL
                     HDSNFKRTTGVDKNVWDVNYNEVKTYDAGSFYYYGKGYYDEKFVGEKIPTLKEMIKYS
                     KGKVKLLIEIKLNGHEKGDVVKKVVQLIKENNFENQCIVASMDKTILQKVKKLDENLL
                     TCYFMAIAYGDFSKLNYVDIYGIESTFVNKTVVEKIHKMNKKIFVWTVNSDSLIEKML
                     DLNVDSIITDNPYLIESAIYWKKNGFISQVSDYLF"
     gene            1954..2538
                     /locus_tag="KR257_003763"
     CDS             1954..2538
                     /locus_tag="KR257_003763"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430125.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sugar O-acetyltransferase"
                     /protein_id="HBH0032413.1"
                     /translation="MTEREKMLAGELYDCGDIELLTQWHKAKDLVRDYNQTDSLDLEK
                     KEKILNELLGGKGKNLWITAPYYVDYGNNIYFGNNCEVNMNCTFLDDNKIIIGDNALI
                     APNVQIYTAFHPTNAGDRFGNAKEDGSFEFCKTQTAPVTIGDNVWIGGGAIIMPGVTI
                     GDNVVIGAGSIVTKDIPSNMIAYGNPCRIIRENK"
BASE COUNT         1145 a          274 c          448 g         1074 t
ORIGIN      
        1 ataaaagttt tgaccaatcc catgtcaata gttctgataa tactatcagt tataatacta
       61 gctttttatg cattttttga atttacctct gtaattattt gttttaataa atcgataaaa
      121 tatgaaaaaa tagggttatt tgaactcttt aaaatatcat ttgagaactc tataaaattg
      181 ttatatccta aaaatatact attatttata tttgtgatat taataattcc attagtaaat
      241 acagttttaa tttcagggtt tataggaaaa atacaaatac cagagtacat attagattat
      301 ataaagtctg atataatttt aaatataatc tatatgattt ttcttttaat aatatatatt
      361 tcggttatta gatggatttt tagcattcat gagataactt taaatacaga aaattttaaa
      421 agagcaagaa aagaaagtgt taatcttata aagggaaaga ttataagaac aattatttat
      481 tcattaatat tatctttagt agtagctatt attggatatg cgatttatca tagtggaatt
      541 atatttatag gcatatggac taaatattgt actgatatgg aatttttgaa gaatgtattt
      601 ataaatagat gtattgcatt tgaagaatat tttagattga ttttatcaat attcattttt
      661 atattggaca ttggatttat ctcagcaact tattatcaat ataaaggagt aaatatttct
      721 aaaaataata ttaaaaaaga gaaaaaatct atatcaaaaa ttgtttttaa tttagtatta
      781 atattattga tttcttatat agagtcagtt gcattttctt cacatataaa tggtatgttt
      841 aatacgtcat tttcatttta tacaacagca attgctcata gagcaggagc tgaaatggct
      901 ccagagaata ctttggcagc aatagaagaa gcttcacatg ctaaagctga ttatgcagaa
      961 atagatgttc aagaaactaa agatggagaa cttattgtac ttcatgattc aaactttaag
     1021 agaactacag gagtagataa aaatgtttgg gatgtaaatt ataatgaagt aaagacatat
     1081 gatgcgggaa gcttttatta ttatggaaaa ggttattatg atgaaaagtt tgttggggaa
     1141 aagataccaa cactcaaaga aatgataaaa tattctaaag gtaaggtgaa attattaata
     1201 gaaataaaac ttaatggaca tgaaaaggga gacgtagtaa aaaaagttgt tcagttaatt
     1261 aaagaaaata attttgaaaa tcaatgtata gttgcatcta tggataaaac tatattacaa
     1321 aaagtaaaaa aactggatga gaatttactg acatgctatt ttatggcaat tgcatatggt
     1381 gatttttcaa agttaaatta tgttgatata tatggaattg aatcaacttt tgttaataaa
     1441 acagtagtag aaaagattca taaaatgaac aaaaaaatct tcgtttggac tgttaatagt
     1501 gacagtttaa ttgagaaaat gcttgaccta aatgtagata gtattattac agataatcca
     1561 taccttatag agagtgcaat ttattggaag aaaaatggat ttattagtca agtgtcagat
     1621 tatttatttt aaatattcta taattgtatt atccagtaaa agagatatta ttaaaatcaa
     1681 taatatctct ttttaacata aataaggttg ttaaattaag gctattctta taaaaattgt
     1741 gtttatcaga tataaataag gaataaaagt aaaaaaattg ctatgacatt attacaatta
     1801 aaagagtttt aatatgatag agaggtagat tgtcaactgt atatttaata aattttatta
     1861 tttattagat tttatataag taaaatatat agatatataa atcttatgct agaatatata
     1921 tgaaaaacaa tatagatttg gagggttaaa agcatgacag agcgagaaaa aatgttggca
     1981 ggagaacttt acgattgtgg tgatattgag ttgttaactc aatggcataa agcaaaagac
     2041 ctagtaagag attataacca aacagattcc ttggatttgg aaaaaaaaga aaaaatatta
     2101 aatgagttac ttggtggtaa gggtaaaaac ttatggatta ctgcaccgta ttatgtagat
     2161 tatggaaata atatttattt tggaaataat tgtgaagtca atatgaattg tacgttttta
     2221 gatgataata aaattatcat tggggataat gcactaatcg caccaaacgt acaaatatat
     2281 actgcatttc atccaactaa tgctggtgat agatttggta atgccaaaga agatggttca
     2341 tttgaatttt gtaaaactca aacagctcca gttactattg gagataatgt ttggattggc
     2401 gggggtgcta ttatcatgcc aggtgttact attggagata atgtagttat aggtgcagga
     2461 agtattgtta caaaagatat tccaagtaat atgattgcat acggaaatcc atgccgtatt
     2521 attcgagaaa ataaataaag ttaaattttc ttgcaaaatc tcaaaaaaca cctttcttac
     2581 tttatacata gggtattttc taatactttc acatccatat tcatttgtta aatttttgtg
     2641 gaatgtagtt tttatcactt ctatcttaca tttccaccat ttttttataa aagtcattcc
     2701 tttatagatt tatttataat agtatatatt ctatttgatg tttgaataag cacttatttt
     2761 taagtaaaat actaacttct aggttagtat tttactatag tatgatgatt aagtaagaat
     2821 aaaatactat aatacataaa gcttaataaa tataattttt attttactta gatattttct
     2881 tttgattagt aatcaaaagt ggttataatt tttttaatta ataagagtaa catttatttt
     2941 a
//
LOCUS       DAEPID010000167         2927 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.171, whole genome shotgun sequence.
ACCESSION   DAEPID010000167 DAEPID010000000
VERSION     DAEPID010000167.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 2927)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2927)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2927
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.171"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            344..1267
                     /locus_tag="KR257_003764"
     CDS             344..1267
                     /locus_tag="KR257_003764"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003439369.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF2520 domain-containing protein"
                     /protein_id="HBH0032414.1"
                     /translation="MGSGKVGTSLANYFLSKGYCVSGFYGRNQLSLLESTNLTKTKIY
                     SNLKDIIYENDILFITTSDDSIEIIDKKLSKFNLKHKYICHTSGSLKSSILFCSKKAG
                     ALIYSIHPIFAFSNKNTNIKKMKDICFSIEGDNEQDDLVIQNFIDDLGNQFFIRDKDT
                     SSTYHLANVLVSNLVLSLLDIGVSYFIKLGLSEEESLKAISPLVKKNIENILDNGFTK
                     ALTGPVSRGDITPIRKHLSVLDKKDEDIYKILSLNLLKIIALGNDNSLKGIKNITIEN
                     AIENLISKSEKYKEIYKLLGGKNDEKYHTDF"
     gene            1242..2069
                     /gene="panB"
                     /locus_tag="KR257_003765"
     CDS             1242..2069
                     /gene="panB"
                     /locus_tag="KR257_003765"
                     /EC_number="2.1.2.11"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011721175.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="3-methyl-2-oxobutanoate
                     hydroxymethyltransferase"
                     /protein_id="HBH0032415.1"
                     /translation="MKNTIQTFKNAKYEGKKLSMLTAYDYSIAKIMDECDINGILIGD
                     SLGMVIKGEENTLSVTIDEIIYHTKAVKNGVKNALIVSDMPFLSYHVSIEDAVKNAGR
                     LIKEGGAHAVKLEGGSNVIKQIESIVNAQIPVMGHLGLTPQSVNSFGGFKVQGNTSET
                     ARQLIEDAKLIEKAGAFSIVLEGVPTKIAEMVTNSISIPTIGIGAGINCDGQILVYQD
                     MLGMFGDFVPKFVKQYANIGDIMKDSIKNYILEVNTGTFPQEKHSFSINESELEKLY"
     gene            2088..>2927
                     /locus_tag="KR257_003766"
     CDS             2088..>2927
                     /locus_tag="KR257_003766"
                     /EC_number="6.3.2.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003439366.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pantoate--beta-alanine ligase"
                     /protein_id="HBH0032416.1"
                     /translation="MLVKEIKLLRNIIKDWRKHGYSIGLVTTMGFLHEGHQSLIKKAV
                     KENDKVVVSVFVNPTQFGPNEDFNSYPRDIDKDFKYCMDSGATVVFNPSPEEMYLKGN
                     CTTINVSGLTDFLCGAKRPVHFGGVCLVVSKFLNIVTPDKAYFGEKDAQQLAVIKRMV
                     KDLNIDTEIIGCPIIRENDGLAKSSRNTYLSEEERKSALILNKSLSLAKEELVKGNLN
                     PENIKELITAKINSEHLAKIDYVEIVDSETLQPVKQIEHSILVAIAVFIGKTRLIDNF
                     TFEL"
BASE COUNT         1167 a          343 c          467 g          950 t
ORIGIN      
        1 tcagtattat tgatactatt gaagttaaaa agcattaatt tctaaaaaca tcataatttt
       61 tctaatagac ttaatcactt ttaatatata tagtaaaaca aaaaacttat attttataaa
      121 tatcataatt tttttactga tattttatta tataaatttt atagaattaa ttgtcaattt
      181 tttatgaaaa tggtaagata tttatggatg gtatcttgtt ataagaacta tactttaaat
      241 gtttttaatt attttgtctt atgtaactca tatcctcagg aatgagatta gaaattaaga
      301 tgttgtatca caaagtggag gtgatactat taaaataggc tttattggtt ctggaaaagt
      361 tggaacatct ttggcaaatt attttttatc aaaaggttat tgtgtttcag gcttttatgg
      421 aaggaatcaa ttatctttat tagaatcaac aaatttaaca aaaacaaaga tttacagcaa
      481 tttgaaagat ataatttatg aaaacgatat attatttatt acaacatcag atgattctat
      541 tgaaattata gacaaaaaac tttccaaatt taatttaaaa cataaataca tttgccacac
      601 aagtggctct ttaaaatcta gtatattgtt ctgttcaaaa aaagcaggtg cattaattta
      661 ttctatccat cctatatttg cattttccaa taaaaatacc aacataaaaa aaatgaaaga
      721 catttgtttt tccatagaag gtgataatga acaagatgat ttagttattc aaaatttcat
      781 agatgatttg ggaaaccaat tttttataag agataaggat acttcatcca cttatcattt
      841 agctaatgtt ttagtttcaa atttagtatt atctttacta gatataggag taagttactt
      901 tattaaatta ggtttatctg aagaggaatc tttaaaagct atcagtcctt tagtaaaaaa
      961 aaatatagaa aatatacttg ataatggctt tactaaagct cttactggtc ctgtttctcg
     1021 tggagatata acaccaataa gaaaacatct atctgtattg gataaaaaag atgaggatat
     1081 ttacaaaata ctatccttaa acctactaaa aataattgcc ttaggaaatg acaattcatt
     1141 aaaaggtata aaaaatatta ctatagaaaa tgcaatcgaa aatttaataa gtaaatctga
     1201 aaaatacaaa gaaatttaca aacttttagg aggaaaaaac gatgaaaaat accatacaga
     1261 cttttaagaa tgctaaatat gaaggaaaaa aactatctat gcttactgct tatgactact
     1321 caattgcaaa aataatggat gagtgtgata taaatggtat tttaatagga gattcattag
     1381 gaatggttat aaaaggtgaa gaaaacactc tatctgttac catagatgaa attatatatc
     1441 atacaaaagc tgtaaaaaat ggtgtaaaaa atgccttaat cgtaagtgat atgccttttc
     1501 tatcttacca tgtttctata gaagatgcag ttaaaaacgc gggtagactt ataaaagaag
     1561 gaggagctca tgctgtaaag ttagaaggtg gctcaaacgt tataaagcaa atagaaagca
     1621 ttgtaaatgc tcaaatacct gtaatggggc atttaggatt aactcctcaa tcagtaaatt
     1681 catttggtgg gtttaaggtt caaggaaata ccagtgaaac agcaagacaa cttattgaag
     1741 atgctaaatt aatagaaaaa gcaggtgcat tctctattgt ccttgaagga gtgcctacga
     1801 aaatagctga gatggtaact aattctattt caattcctac aataggtata ggggcaggaa
     1861 ttaactgtga tggacaaatt ttagtttatc aagatatgtt gggaatgttt ggagattttg
     1921 ttcctaagtt tgtaaagcag tatgcaaata taggagatat aatgaaagat tcaattaaaa
     1981 attacatcct agaagttaat acaggtacat ttccacaaga aaaacacagc ttttcaataa
     2041 atgaatctga gttagaaaaa ttatactaat attaaggatg gtacaaaatg cttgtaaaag
     2101 aaattaaatt actaagaaat ataatcaaag attggagaaa acatggctat tctatagggc
     2161 ttgttacaac aatgggattt ttacatgaag gacaccaaag tcttataaaa aaagctgtaa
     2221 aagaaaatga taaagtagta gtgagtgtat ttgtaaatcc aactcaattt ggaccaaatg
     2281 aagattttaa tagctatcca agagatatag ataaagattt taaatattgt atggatagtg
     2341 gagcaacagt agtctttaac ccatcaccag aagaaatgta tttaaaaggt aattgtacta
     2401 ccattaatgt ttctggactt acagattttc tttgtggagc taaaagacct gttcattttg
     2461 gaggtgtctg cctagttgtt tcaaagtttc taaatatagt aacacctgat aaagcttatt
     2521 ttggagagaa ggatgcccaa caattagctg taattaaaag aatggtcaag gatttaaaca
     2581 tagatacaga aataataggc tgtcctataa ttcgtgaaaa tgatggatta gcaaaaagtt
     2641 cgagaaatac atatctctct gaggaagaac gaaaatctgc tctaatatta aataagagct
     2701 taagtttagc aaaagaagaa ttagtaaaag gcaatctaaa tccagagaat ataaaagaat
     2761 taataacagc taaaataaat tctgaacact tagcaaaaat agactatgtt gaaattgtag
     2821 atagtgagac attacaacct gttaagcaaa tagaacattc tatacttgtg gcaattgctg
     2881 tgtttatagg aaaaaccaga ctaattgata attttacatt tgagtta
//
LOCUS       DAEPID010000168         2922 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.172, whole genome shotgun sequence.
ACCESSION   DAEPID010000168 DAEPID010000000
VERSION     DAEPID010000168.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 2922)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2922)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2922
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.172"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            <1..458
                     /locus_tag="KR257_003767"
     CDS             <1..458
                     /locus_tag="KR257_003767"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015984839.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=3
                     /transl_table=11
                     /product="phage portal protein"
                     /protein_id="HBH0032417.1"
                     /translation="ELLDRLEKNIIIFGQGVNPESQNTGDKSGVALKFLYSLLDLKCS
                     KTEKKFKKAIRELLWFVCEYLKISGSKSYDYKTVQITFNHSMIINEAEKIDMAAKSTG
                     IVSDETIVSNHPWVEDVNDELERLKKQEDTQKEYDDLIPNNQDGVIDET"
     gene            448..1941
                     /locus_tag="KR257_003768"
     CDS             448..1941
                     /locus_tag="KR257_003768"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003433532.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="minor capsid protein"
                     /protein_id="HBH0032418.1"
                     /translation="MKHKDYWRKRFEQLEEAQNNKSVKYYLELEKQYKLAINSIEKDI
                     LAWYNRFAKNEGISLLEAKKLLNTRELEEFKWSVEEYIKYGKENAINQKWMKELENAS
                     ARVHITRLEALKLQIQQQVEVLYGNELDGIDKLMRDIYTSGYYHTAFNVQQGVNVGWS
                     LMSLDTNRINKIISKPWAIDGLNFSERIWGKYRPTLVNELHTKLTQSIIRGENPKNLV
                     NDFAKRFNVSKSQAKNLIMTESAFFASASRKDCFSDLEVEKYEIIATLDLRTSNICRE
                     LDGKIFDMKDYQVGITAPPFHCRCRTTTAPWFEDEEGYRAARGEDGKTYYVPSSMKYN
                     EWYEKYVKNNSKQTGAKYTKGDIEWNIRREEEAELYYDNIRNRKDDISKISKNTNWSE
                     KSIGQIKNHIFYNTHIMRDGTRRMLDSDYSMSVAWQRLINGTYEDIDILLLKHEYLES
                     IFEKKYNISNLEAHRMTEKKHDWYKELIKQKGEFEEDDCLNELIRKE"
     gene            1907..2149
                     /locus_tag="KR257_003769"
     CDS             1907..2149
                     /locus_tag="KR257_003769"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009901430.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0032419.1"
                     /translation="MIVLMNLLEKNNEYVIYSYGYEENKLDGRIKIYLDDFYNYEIIK
                     ESKDEHISKSATLKAISKLIKAAKNNDLKKEMSYQC"
     gene            2220..2414
                     /locus_tag="KR257_003770"
     CDS             2220..2414
                     /locus_tag="KR257_003770"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015981492.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0032420.1"
                     /translation="MYILTQVIAVVCVVQIFINCIANVNVGILCNKLKEKNEANIDKV
                     SDEILKRVGEELNESLDKSL"
     gene            2459..>2922
                     /locus_tag="KR257_003771"
     CDS             2459..>2922
                     /locus_tag="KR257_003771"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728455.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phage scaffolding protein"
                     /protein_id="HBH0032421.1"
                     /translation="MDWLKELLEGIKIENNKIDVVSLQKSIEKKIKETTITQEDYTNL
                     ETQLNTANETIKKFEGGMTKEDVENLKTTYETDKKTLEETYKKEIEEKDFNYWLGDAF
                     KSVKCRDEIALKAHLDIEALRNSKDRQKAFEEQINPLKQDKDYLFNATLEGE"
BASE COUNT         1264 a          276 c          532 g          850 t
ORIGIN      
        1 aggagcttct tgatagattg gaaaagaata taattatctt tggtcaagga gttaatccag
       61 aatctcaaaa cacaggtgac aaatcgggtg tagcacttaa atttttatat tcactacttg
      121 acttaaaatg ttctaagact gaaaagaagt ttaaaaaagc aattagagag cttttatggt
      181 ttgtgtgtga gtatttaaag ataagtggta gtaagagcta tgattataaa acagttcaaa
      241 ttacttttaa tcactctatg ataataaatg aagctgaaaa gatagatatg gcagctaaat
      301 caactggaat tgtatcagat gaaactattg tttctaacca tccttgggtc gaggatgtta
      361 atgacgaact tgagagactt aaaaaacagg aagatactca aaaagagtat gatgatttaa
      421 ttcctaataa tcaagatggt gttatagatg aaacataaag attattggag aaagagattt
      481 gaacaattag aagaagctca aaataacaaa agtgtaaaat attatcttga attagaaaag
      541 caatataaac tagctataaa tagtatagaa aaagatatat tagcatggta caacagattt
      601 gccaaaaatg aaggaatatc tttattagaa gctaagaaac tactaaatac aagagaacta
      661 gaagagttta aatggagtgt tgaagaatat attaaatatg gtaaagaaaa tgctataaat
      721 caaaagtgga tgaaagagtt agaaaatgct agtgcaagag ttcatataac aaggcttgaa
      781 gctttaaagt tacaaataca gcaacaagta gaagttttat atggaaatga acttgatggt
      841 attgataaac taatgagaga tatttataca agtggatact atcatacagc ttttaatgtt
      901 caacaaggag taaacgttgg ttggagttta atgagtcttg atactaatag aataaataaa
      961 attatctcta aaccatgggc aatagatgga ttaaacttta gtgaaagaat ttggggtaag
     1021 tatagaccta ctttagtaaa tgaactacat actaagctaa ctcaatcaat tattagaggt
     1081 gaaaatccaa aaaatttagt aaatgacttt gctaagagat ttaatgtatc taaatcacaa
     1141 gctaagaatt tgataatgac tgaatcagct ttctttgcat cagcaagtag aaaagattgt
     1201 tttagtgatt tagaagtaga gaaatatgag attattgcta cattagattt aagaacttca
     1261 aatatatgca gagagttaga tggaaaaata tttgatatga aagattatca agttggaata
     1321 acagctccac catttcattg tcgttgtagg acaacaacag ctccttggtt cgaggatgaa
     1381 gaaggctata gagcagcaag aggagaagat ggaaaaacat attatgtacc atctagtatg
     1441 aagtataatg agtggtatga gaagtatgtt aaaaataata gtaaacaaac tggtgcaaaa
     1501 tatactaaag gtgatatcga gtggaatata agaagagaag aagaagcaga actatattac
     1561 gataatatta gaaatagaaa agatgatatt tccaaaatat caaagaatac aaattggtca
     1621 gaaaaaagta taggtcaaat taaaaatcat attttctaca atactcatat aatgagagat
     1681 ggaactagac gtatgttgga ttctgactat agtatgtcag ttgcttggca aagacttata
     1741 aatggtacat acgaagatat tgatattctc ttattaaaac atgaatacct tgaaagtata
     1801 tttgagaaaa agtataatat aagtaactta gaagcccata gaatgactga gaaaaagcat
     1861 gattggtata aagaattaat taaacagaaa ggagagtttg aagaagatga ttgtcttaat
     1921 gaacttatta gaaaagaata atgaatatgt tatatatagt tatggatatg aagaaaataa
     1981 gcttgatgga agaataaaaa tatatttaga tgatttttat aattatgaaa taataaaaga
     2041 gtcaaaagat gaacatataa gtaaatcagc aacgttaaaa gctatttcta aacttataaa
     2101 agctgctaaa aataacgatt tgaaaaaaga aatgagttat caatgttaga agcacttact
     2161 gaacaataaa ttagtaggtg cttttattat gtaaaagttt aaaaaagtag gtgattttaa
     2221 tgtatatatt aactcaagtt atagctgtag tttgtgtagt acaaatcttt attaattgta
     2281 ttgctaatgt caatgtaggt attctttgca ataaattaaa agaaaaaaat gaagctaata
     2341 tagataaagt ttctgatgaa attctaaaga gagtaggaga agaattaaat gaatcactag
     2401 acaaaagtct ttaaagactt tttttattgt gtaaaaaatg aaaggagata tttaaaagat
     2461 ggattggtta aaagaattgc tagaaggaat aaaaatagaa aataacaaaa ttgatgtagt
     2521 ttctcttcaa aaatctatag aaaagaaaat aaaagagact acaattactc aagaagatta
     2581 tacaaatctt gaaacacagc ttaatacagc taatgaaact attaaaaagt ttgaaggagg
     2641 tatgacaaaa gaagatgtag agaatctaaa aacaacttat gaaactgata agaaaacttt
     2701 ggaagaaact tacaaaaaag aaattgaaga aaaagatttt aattactggt taggtgatgc
     2761 ttttaaatct gttaaatgta gagatgaaat agcattaaaa gctcatttag atatagaagc
     2821 actaagaaat agtaaagaca gacaaaaagc ttttgaagag caaataaatc ctttgaaaca
     2881 ggataaagat tatttgttta atgcaacact agaaggtgaa ga
//
LOCUS       DAEPID010000169         2904 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.173, whole genome shotgun sequence.
ACCESSION   DAEPID010000169 DAEPID010000000
VERSION     DAEPID010000169.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 2904)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2904)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2904
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.173"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            379..672
                     /locus_tag="KR257_003772"
     CDS             379..672
                     /locus_tag="KR257_003772"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889969.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="winged helix-turn-helix transcriptional
                     regulator"
                     /protein_id="HBH0032422.1"
                     /translation="MGFPETFKALSDPIRREILVMLRENKMSAGEISEKFNMTNATIS
                     YHLSQLKKAGLIFETKYKNFIFYEINISVFEEVMLWFSQFMEKGEKDNEKSDK"
     gene            653..1294
                     /locus_tag="KR257_003773"
     CDS             653..1294
                     /locus_tag="KR257_003773"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435225.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SdpI family protein"
                     /protein_id="HBH0032423.1"
                     /translation="MKKAINKQFILSTLICFIPFIVSIYFYNRLPNEVAIHFDNYGNP
                     DNYAPKVIAAFGVPLLMLCIHLYTWFRLENEPKKANFSNVIQNLSKWGVAILSVIIQI
                     MMVLYSTGVSLESNFYTGLILGIIVILFGNYLPKCKRNYSVGIILPWTLNDEDNWNKT
                     HHLAGWIWLIGGILLIINAFINIPFYNIFVIFVIVILPFVYSYLMYKISGKNN"
     gene            1538..1870
                     /locus_tag="KR257_003774"
     CDS             1538..1870
                     /locus_tag="KR257_003774"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435227.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="carboxymuconolactone decarboxylase family
                     protein"
                     /protein_id="HBH0032424.1"
                     /translation="MNTREMKEYRGFYNKKLSETDEFFRVFGSLDDKTYSEGAISKKN
                     KELMGLAISILSRCDECICYHIEGCINSGASKDEIIEAIKIGVIGGGSITYPNARFAI
                     KILEEFNI"
     gene            2412..2576
                     /locus_tag="KR257_003775"
     CDS             2412..2576
                     /locus_tag="KR257_003775"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424195.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0032425.1"
                     /translation="MFGKPKESVRFLDFNDVAEKFGEKKAVAIFDAIAGKKSKEHIIK
                     DIEKLVKNEV"
BASE COUNT         1107 a          242 c          437 g         1118 t
ORIGIN      
        1 agtagatgtt tttatgtact tttatacagt atatttctcg tttcattctt ttctatttaa
       61 ataggactta actacttttt aaattgggtt tagctacttt taatttaaaa ttaaaagtat
      121 tgttatatat ataagtacct cagtcattag gtttttgctt taacaattat ggtgcaatac
      181 acttttgtta agttaaaaaa attagataaa gtaagattaa ataaaagcga cttaagtaaa
      241 ttgagaatct taatatgaaa attttcaata aatatttaga aataactatt tagaaaaaat
      301 tctaaatagt tattgaaata aaatggatgt tatgttatat tctatttaga tgaaattcta
      361 aatagcgagg tgatggtgtt ggggtttcca gaaacattca aagctctttc agaccctata
      421 agaagagaaa tattggttat gttgagggag aataaaatgt cagcaggaga aattagtgaa
      481 aaatttaata tgacgaatgc tacaatttct tatcatctat ctcaactaaa aaaggcagga
      541 ctcatatttg aaacaaagta taagaacttt attttctacg aaataaatat ttcagttttc
      601 gaagaggtta tgctttggtt ttcgcaattt atggagaagg gagaaaaaga taatgaaaaa
      661 agcgataaat aaacaattta ttttatctac tttaatatgt tttataccat ttattgtatc
      721 aatatatttt tataatagat taccaaatga agttgcaatt cattttgata attatggaaa
      781 tccagataat tatgctccaa aggttatagc agcttttggt gtaccattgt taatgctatg
      841 tatccatttg tatacatggt ttagacttga gaatgagcct aagaaagcta atttttcaaa
      901 tgttatacaa aatttatcaa aatggggagt tgctatactt tcagtaatta tacaaataat
      961 gatggtttta tattcaacag gagttagttt ggagtctaat ttttatacag gattaatttt
     1021 aggaataata gttattttat ttggaaacta tcttcctaaa tgtaaacgaa attactcagt
     1081 aggaataatt ttaccatgga ctcttaatga tgaagataat tggaataaga cacaccattt
     1141 agctggatgg atttggctta ttggtggaat attattaatt attaatgcat ttattaatat
     1201 tcctttttat aatatctttg taatctttgt aattgtaata ctaccatttg tatattctta
     1261 tttgatgtat aaaatttcag gtaaaaataa ctaatataat taatcactat aataatgttt
     1321 ggataagaat aatatatttc agaactgaga tagataataa agaaattact gagatttcta
     1381 ttttagttct gaaaaaatct tacttatatg ataacttatt gagatttcaa aaaataatat
     1441 aaattaggct aatgaacata aaatgaaaat ttgtatttaa tattgaaaat ataagtacag
     1501 tgtgatactc ttataagaaa aaaataggag gtagaagatg aatactagag aaatgaaaga
     1561 atatagggga ttttacaata aaaaattaag tgaaacagat gagtttttta gagtatttgg
     1621 aagccttgat gataagactt attcagaagg ggctataagt aaaaaaaata aggaattaat
     1681 gggactagct atttcaattt taagccgatg tgatgagtgt atttgttatc atattgaggg
     1741 ttgtattaat tctggagcaa gtaaagatga aattatagaa gctataaaaa taggtgtaat
     1801 tggtggaggg tctattacat atccaaacgc aagatttgca ataaaaattt tagaagaatt
     1861 taatatataa ttttgataca cgtagtttat ttagactaat aataatagtc tatttaagcc
     1921 tttgaaatta agctttattt tctaagttca cttcttatta agtttttaga attgcatata
     1981 taaatataaa tttttaaata atatagtagt tttaaattat ttacatcata gattgtattg
     2041 agaatagtat attgtcatta ttaaatcttt tatacatttt ttactttaaa taaattgaat
     2101 attaaggtga ttatatttac atatttgtat ttttatgaac tagaatattc tttataaatt
     2161 catagcagtt ttaatagata actttttcag atagattaaa caaagtttta tttactgtat
     2221 tctattatca gtttcctaca aattaaattg tctattttta tttatagagt agaataaact
     2281 gtttttgtta agaattttga aggtaaagct agtttaaaaa aataaaggga ctaatttgtc
     2341 taacgtttat tggtgaaaaa taagtctata gaagttataa taaatatata aaaatgtatg
     2401 agaggtgtta tatgtttggt aaaccaaaag aaagtgttag atttttagac tttaatgatg
     2461 tagcagaaaa gtttggagag aaaaaggctg ttgcaatttt tgatgccata gctggaaaaa
     2521 aatctaaaga acatattatc aaagatatag aaaaattagt aaaaaatgaa gtttagatat
     2581 ttataaggta tattgagctt gagggtagct ctttatacct tcttttttat gatttttaga
     2641 taatatttta aaatttaaat aagaaactta ttgttataga gtaatattta tatagaaata
     2701 agtctttata atttaaactt gtaattagtt tagtagagat tatgattcag tgctgaatta
     2761 tacataaaaa aatattttat aaattcaaaa attaaatatc tagtttagat gtttttttat
     2821 tgtatttaga ttatattttg ggtctttatt atctttgtta aagtataagg ctttatttaa
     2881 atattgttgt gcttcatcaa atct
//
LOCUS       DAEPID010000170         2843 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.174, whole genome shotgun sequence.
ACCESSION   DAEPID010000170 DAEPID010000000
VERSION     DAEPID010000170.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 2843)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2843)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2843
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.174"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            complement(426..1856)
                     /locus_tag="KR257_003776"
     CDS             complement(426..1856)
                     /locus_tag="KR257_003776"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422900.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4116 domain-containing protein"
                     /protein_id="HBH0032426.1"
                     /translation="MDIKNKIKSIFLPEKNDYLDDEEFEYDIENNEEDLKEDNKVHLN
                     DLSRVKYDYRELKDIENQTEEMCLLAVKQDGTIIEFVKDKTYKVCMEAVKQTYKSLKY
                     ITNQNEDICIEAVKQNYRALYYINNKTENVLIEAIKNASTYDVMEVFKFVEEQTEDVC
                     LAFIERASKNDVAEILKGIKEQTPAICLEAVKKDGKSLAYVKEQSNSICLEAVKENYS
                     ALSCVKEQTEEICIEAVKQNDFALYYVNEQTEKICMEAVKRSYMALQYVNKQTEEICL
                     EAVRIDGRALQYVKEQTEEICLESVRQNGKVLQYVKKQTENICIEAVRGSFEELEIKE
                     ILSYVKIPTERIFVEAVKQNGKILKYVENQTELICLEAVRENYNALAYVKEQTEKICL
                     EAVNQSYEALKYVKEQTEEVCLKAVKQDYRMLKYVNNQTEKICLEAVKQNYRALEFVD
                     NQTEKVCLEAVKQNRKALQYVKQKQS"
     gene            2200..>2843
                     /locus_tag="KR257_003777"
     CDS             2200..>2843
                     /locus_tag="KR257_003777"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454127.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0032427.1"
                     /translation="MKGNIVQYNFADIEEEVYSLDYAIAWNTDEENVNIIPFTNKFCK
                     ESIESFCLGKINNFVEILNEGFVENHHYVHLDKMISVPKKKVNLVYQQDTHGYLLRDD
                     NDNLIPAKITSEQSKSISSKMELFCAGEEKCLINILLKADPSYILDVDSIKDKNILNL
                     GYESIDRYKEYNFDDDKILIFFINKKRYSVIMKKTNNSDNDLVSRNNAIKELFT"
BASE COUNT          922 a          433 c          287 g         1201 t
ORIGIN      
        1 ctatcatatt attacaaatt aaaacagatg tcattttttc agcatatctt ttaaacattt
       61 ttacctccaa aaaaatttta catatataga gtacattctt ttttgagaaa attcaatata
      121 ctttacaaaa ctagttgtta aaaatgtaaa actggtcaaa aaaagaccta tataattttc
      181 ttcttattat ttatataaca aaacaattat aataaaacaa ttttatcaag ctttatatgc
      241 ataaaaagcc tatgtcaaaa tagaaataaa ccttttcccc attgttaaaa ggctaaaaat
      301 atatttcatt tcatataaaa agagtacctc acaaactaaa aagttccttt tgagataccc
      361 attttattta ttacaaaata tcaaatttta tttatttgca tatgttttct atatatttta
      421 gccttttaac tttgtttttg ttttacatac tgtagtgctt ttctattctg ttttactgct
      481 tcaagacaaa ctttttctgt ttgattatca acaaattcta aagctctata attttgcttt
      541 actgcttcta aacatatttt ttctgtttga ttatttacat atttcaacat tctataatct
      601 tgttttactg cttttagaca aacttcttct gtttgttctt tcacatattt aagcgcttca
      661 taactttgat taactgcttc taaacaaatc ttttctgttt gttcctttac ataagctaaa
      721 gcattatagt tttctcttac tgcctctaaa catattaatt ctgtctgatt ttctacatat
      781 ttaagaattt ttccattttg ctttactgct tctacaaata ttctttctgt tggtatcttt
      841 acataactta atatttcttt tatttcaagt tcttcaaatg aacctcttac tgcttctata
      901 catatatttt cagtctgttt ttttacatat tgcagtactt ttccattttg tctaactgac
      961 tccaagcaaa tttcttctgt ttgctctttt acgtactgta atgctcttcc atcaattctt
     1021 actgcttcca aacaaatctc ttctgtttgc ttatttacat actgtagagc catataactt
     1081 ctttttactg cttccataca tattttttct gtctgttcat ttacataata caatgcaaag
     1141 tcattctgtt ttactgcttc tatacatatt tcttcagttt gctcttttac acaagatagt
     1201 gcactgtagt tttcttttac agcttctaaa catatactat tactttgttc ctttacataa
     1261 gctaaagatt ttccatcttt ttttacagct tctaaacata tggctggagt ttgctctttt
     1321 attcctttta atatctctgc aacatcattt ttagatgccc tttctataaa tgctagacat
     1381 acatcttctg tttgctcttc cacaaattta aatacttcca tgacatcata agttgatgca
     1441 ttttttatag cctcaattag tacattttct gtcttattat ttatgtagta caaagctctg
     1501 tagttctgtt ttactgcttc tatacaaata tcctcatttt gatttgttat atacttaaga
     1561 gatttatatg tctgttttac tgcttccata catactttat aagtcttgtc ctttacaaac
     1621 tcaattatag taccatcctg ctttactgct agcagacaca tctcttctgt ttggttttct
     1681 atgtctttta actctctgta atcatatttt actctgctta aatcatttaa atgtactttg
     1741 ttatcttcct ttaaatcttc ttcattattt tctatatcat actcaaattc ttcatcatct
     1801 aaatagtcat ttttttctgg taaaaatata gatttaattt tattctttat atccataaaa
     1861 ttatcctcct ttaatatgat tctatcatta aagtaaatcg tttttaagca cttatttaat
     1921 taattttata ttaagtttat ttaaaagtct attcattgtc gatagattat attttatatt
     1981 aataatttta tcttatatat gtggggtaat aaagttaata gtggacattt tccatcccat
     2041 tagtatacac tatttatatt tattactcat ttatagtgat ttttttcaaa ttttttctta
     2101 tttactatat catatttatt caatttatga tattatttaa atataatata agttttataa
     2161 agtatattaa atatattata agatggaggt cgagtaattt tgaaaggaaa catagtacaa
     2221 tataattttg cagatataga ggaagaagta tattcgttgg attatgctat agcatggaat
     2281 acagacgagg aaaacgtaaa cataatacca tttacaaata aattctgtaa agaatctata
     2341 gaatcttttt gcctaggtaa aattaataac tttgttgaaa tattaaatga aggttttgtt
     2401 gaaaatcatc attatgtaca tttagataaa atgattagtg ttcctaagaa aaaggttaat
     2461 ttagtatatc aacaagacac acatggttat cttctaagag atgataatga caaccttatt
     2521 cctgcaaaaa taacttcaga gcaatctaaa tctatatcaa gtaagatgga gttattctgt
     2581 gctggtgaag aaaaatgttt aattaatata ttactaaagg ctgacccatc atatatttta
     2641 gatgtagata gtataaaaga caaaaacatt ctaaatctag gttatgagtc tatcgacaga
     2701 tataaagaat acaattttga tgatgataag attttaatat tttttataaa taaaaaacgt
     2761 tattcagtga ttatgaaaaa aacaaacaac tctgataacg atttagtttc cagaaacaat
     2821 gctattaaag aattatttac taa
//
LOCUS       DAEPID010000171         2711 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.175, whole genome shotgun sequence.
ACCESSION   DAEPID010000171 DAEPID010000000
VERSION     DAEPID010000171.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 2711)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2711)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2711
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.175"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            68..141
                     /locus_tag="KR257_003778"
     tRNA            68..141
                     /locus_tag="KR257_003778"
                     /product="tRNA-Gly"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:100..102,aa:Gly,seq:tcc)
     gene            150..266
                     /gene="rrf"
                     /locus_tag="KR257_003779"
     rRNA            150..266
                     /gene="rrf"
                     /locus_tag="KR257_003779"
                     /product="5S ribosomal RNA"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00001"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: cmsearch."
                     /db_xref="RFAM:RF00001"
     gene            540..2558
                     /locus_tag="KR257_003780"
     CDS             540..2558
                     /locus_tag="KR257_003780"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892871.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="N-acetylmuramoyl-L-alanine amidase"
                     /protein_id="HBH0032428.1"
                     /translation="MRRNTKLLTTGILSMAIVAPTMAFATESNAMENNADLNINLEKK
                     SIVLGSTSKVSVKFKEKPDADSITLKYKCYDMPLDTTLNYNQSTESYEGTINYNKDPE
                     YLNVWELQGITINSKNNPKTLNKQELEKMGLNLKDYNVTQECIIEDITSRKDVNKYLR
                     KTSAPITELTGSDRYETAVKISKEGWKNGSDKVVIINGDVSIDGIISTPLATTYNAPI
                     LLVEKNNVPNSVKSELKRLNPRDVIIIGDENAISKTTANQIKSTVNASQTRLKGSNRY
                     ETSLLIAKEIDKNHDVEKVYITNANGGEVDALTIAAKAGQDKQPIILTDKNSITDNTY
                     KWLKSEDLQNAYFIGGPQMISTNVINKVNDITKDNVTNNRVYGADRHETNANVIKKFY
                     TDDELEAVLVAKSDVLVDALAAGPLAANLKSPILITPKTYVSAYHKENLEAKSANKVY
                     KIGGGLTSKVMNSIASSLSKHNTTPTEPGNSGGKTVMIDPGHGGSDTGTTGKPLGGIK
                     EKDYTLNTSLATTEYLRSKGFNVIMTRDTDKTLSLGNRTALSNSLRPDLFTSIHYNAS
                     DTTGNGVEVFYKLKDKDGGTTKTVATNILNRILEKFNLKNRGAKTRTLSTDPTKDYLY
                     VLRNNDMPAVLVECAFLDNEKDMSLLNTSNKVKEMGTQIGKGIEDSLK"
BASE COUNT         1096 a          348 c          466 g          801 t
ORIGIN      
        1 gatatatatg tagtttttag agtgctaact ctaaaaaatt agttttacta atttataaaa
       61 atttaatgcg ggtgtagctc aatggtagag ttctggcctt ccaagccagc tgtgagggtt
      121 cgatcccctt cacccgctcc aaaagattat gtggttacaa tagcagagag gatacacctg
      181 ttcccattcc gaacacagaa gttaagctct ctagcgctga tggtacttgg tgggaaactg
      241 cctgggagag taggacgtag ccacgtaatc tttttttgtt gtattaaatt taataaacct
      301 acaattgtta tatgttttta tttgtctttt atagattttt ttggcaataa atgatatagt
      361 gaagataatt aaatatattc aatatattta atttttttat tttttgtttt tataattttt
      421 ttagaagttt attttttatg tacttattta taattttggg taaaaacact ttgatataat
      481 ttcaaaaatt aaaaggttaa aaaacaaagt agaaatttat gttaaataag gagattaata
      541 tgagaagaaa tacaaaatta ttaacaacag ggattctttc aatggcaatc gtcgcaccta
      601 caatggcatt tgctactgaa tctaatgcta tggaaaataa cgctgattta aatataaact
      661 tagagaaaaa aagtatcgtt ttaggtagta cctcaaaagt cagtgttaag tttaaagaaa
      721 aaccagatgc agatagcatt acattaaagt ataaatgcta tgatatgcca ttggatacaa
      781 ctttaaacta caatcaatca actgagtcat atgaaggaac tatcaattat aataaagacc
      841 cagaatatct aaatgtttgg gaactacaag ggataacaat aaacagcaaa aataatccta
      901 aaactttaaa caaacaagaa ctagaaaaga tgggattaaa tttaaaagac tataatgtaa
      961 cacaggaatg tataattgaa gatataactt ctagaaaaga tgtaaataaa tatttaagaa
     1021 aaacttctgc acctattaca gaacttacag gaagtgatag atacgaaaca gcagttaaaa
     1081 taagtaaaga aggctggaaa aatggttcag ataaggtagt tataataaat ggggatgtaa
     1141 gtatagatgg cattatatca actccactag caactacata taatgcgcca atacttttgg
     1201 ttgaaaaaaa caatgtacct aatagtgtaa aatcagaatt aaagcgttta aatcctaggg
     1261 atgtaattat aattggagat gagaatgcta tttctaaaac tactgctaat caaattaaat
     1321 cgactgtaaa tgctagtcaa acacgtctaa agggctctaa tagatatgag acatctttat
     1381 tgatagcaaa ggaaatagat aaaaatcatg atgtggaaaa agtgtacata acaaatgcta
     1441 atggcggaga agtggatgca cttactatag cagcaaaagc aggtcaagac aagcaaccaa
     1501 ttatattaac tgataaaaat agtattacag acaacacata taaatggtta aagagtgagg
     1561 atttacaaaa tgcttatttt ataggtggcc ctcaaatgat atcaacaaat gttataaata
     1621 aggtaaatga tataactaaa gataatgtta ctaataatag agtatatgga gcagatagac
     1681 acgaaacaaa tgcaaacgta ataaaaaaat tctatacaga tgatgagcta gaggctgttt
     1741 tagtagctaa atcagatgta cttgttgatg ctttagcagc aggtccattg gctgccaact
     1801 taaaatctcc aatacttata acaccaaaga cgtatgtatc tgcataccat aaagaaaact
     1861 tagaagctaa atcggctaat aaggtatata aaataggagg aggattgact tctaaggtaa
     1921 tgaactctat agcatcatca ttatctaaac acaatacgac tccaacagaa ccaggaaata
     1981 gtgggggtaa gacagttatg attgacccag gacatggtgg ttcggacact ggaacaacag
     2041 gtaaaccatt agggggtatt aaagaaaaag actatacatt aaatacttca cttgcgacaa
     2101 ctgaatattt acgttcaaag ggattcaatg taataatgac aagagataca gataagactt
     2161 tatctcttgg aaatagaact gctttatcta actctttgag accagattta tttacgagta
     2221 tacactataa tgcatctgat acaactggga atggtgtaga agtattttat aagcttaaag
     2281 ataaagatgg aggaactact aagactgtag ctacaaatat attaaataga atcttagaga
     2341 aatttaatct aaaaaataga ggtgcaaaaa caagaacact atcaactgac cctacaaaag
     2401 attatttata tgttttaaga aataatgata tgccagctgt acttgtagaa tgtgcatttt
     2461 tggataatga gaaagatatg agtttactta atacatcaaa taaagtaaaa gaaatgggta
     2521 cacaaatagg taaaggcata gaagattcat taaaatagtc tacaatgaga gcatagaaaa
     2581 atttaaaata aattaatcta taattttaaa tttaaactaa agctataaga taagaatgta
     2641 attataatag taataaagac tgtatataca ttgtgcatat aaatgcgaaa tgaggtatat
     2701 acagtctttt t
//
LOCUS       DAEPID010000172         2558 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.176, whole genome shotgun sequence.
ACCESSION   DAEPID010000172 DAEPID010000000
VERSION     DAEPID010000172.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 2558)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2558)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2558
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.176"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            complement(607..1158)
                     /locus_tag="KR257_003781"
     CDS             complement(607..1158)
                     /locus_tag="KR257_003781"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454500.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HBH0032429.1"
                     /translation="MSINTVIAKNLNRLRNERNLSLGQLAELSGVSKVMLSQIEKGDS
                     NPTVNTIWKIASGLNVPYTAILEQPQNETFIVSKTDIDVQVSENKDYRLYCYYPNTPT
                     RNFELFQMELEEGHSYTSVGHSEKSQEYIMIIEGQLKLEVNDSIYQLRENDSICFSAE
                     SIHTYHNQGEKTLKAVIINYYPV"
     gene            1349..2311
                     /locus_tag="KR257_003782"
     CDS             1349..2311
                     /locus_tag="KR257_003782"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896810.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cysteine synthase family protein"
                     /protein_id="HBH0032430.1"
                     /translation="MRVLNNVTEAIGNTHMLHLSKIADEFGVQGNIYAKMEYLNPGFS
                     KKDRVALQMITEAENAGLLVPGQAVVELTSGNTGTGLAIACACKGYKFIACMSKGNSM
                     ERARMMKALGAEVVLVDQMPNSVHGQVSGEDLALVEIEAQKIAKERNAFRADQFNLEA
                     CNHAHEKYTAEEMWEQLDGNIDVFVDFLGSGSTFAGCSKTLKKHNSSIKCYVVEPETA
                     AIYSGKEITDQGHKIQGGGYSMDLPLVDKKLIDGYIQVTDEEATDVARKLAKLEGVFA
                     GFSSGANVCAAIKLLKSSEKGKNIVLTLNDSGLKYLSTDLYEEL"
BASE COUNT          978 a          272 c          419 g          889 t
ORIGIN      
        1 taaagatttt tatatttttg tcattaccat tatgttttaa tatactattc aattatttaa
       61 cctcttaaat tatatttaga tataggagtc ttatgataaa agtaagctta tgtgttattt
      121 gtagtaaata taaagtgcat atagtgataa aacaaaagtt tcatataaat gaagaaaaaa
      181 atataaaata atttatttaa ctacttaaaa ataaactaaa agggataata aaatagcttt
      241 tagtttatgg taatagaggt atttaaaaag agtgcataag cactccaatt gtgagaaata
      301 catacacaaa tcattattac aacaatgaaa aatgtacata taagagacgt tttgtatttg
      361 ttttaagtga taatatttta atactaacta aataattatc acaatggtaa aaaagaaaaa
      421 ggagtatttt gtactccatt tgtcaaaaat ataaaacttt tatataagct tattataaca
      481 taattgataa aagtgtaaag atatataatg aatttataaa gaaaaataaa ataaaaaaga
      541 taaatcctaa tcaaaggatt tatctttttg tatagaaaat aattattcta ttattaaatg
      601 gcatggctaa actggataat aatttattat tactgctttc aatgtttttt ctccttgatt
      661 atggtatgta tgaattgatt cagctgaaaa acaaatagag tcattttctc taagttgata
      721 aatagagtca tttacttcta attttaattg accttctata atcataatat attcctgtga
      781 tttttcagaa tgaccaacag atgtataact atgaccttct tctaattcca tttgaaataa
      841 ttcgaagttt ctagttggtg tattgggata ataacaataa agacgataat ctttattttc
      901 tgaaacttgt acatctatat cagtttttga tacaataaaa gtttcatttt gaggttgttc
      961 cagtattgca gtatatggaa catttagtcc acttgcaatt ttccaaattg tgtttactgt
     1021 tgggtttgag tctccctttt caatttgaga aagcattact ttacttacgc cagataattc
     1081 agcaagttga cctagactta agttacgttc attacgtaat ctatttaaat ttttagcaat
     1141 aacagtatta atactcatag tagctcctta aaatgtaaat tattgacaaa tataatttac
     1201 gaatgtataa tttatttaac attatttata atttacaaat gtataatata atgaacgtta
     1261 aatacactgt acatccgtaa tataaattat actgcataaa gagttgtttt tcaacggatg
     1321 atagttgaga gattaagggg gaattgtaat gcgtgtactt aataatgtta cagaggctat
     1381 aggcaatact catatgttac atttatccaa aatagcagat gaatttggag ttcaaggtaa
     1441 tatttatgca aagatggaat acttaaatcc gggatttagt aaaaaggacc gtgtagcatt
     1501 acaaatgatt accgaagcag aaaatgcagg tttattagtt ccaggtcaag cagttgtgga
     1561 attaacaagt ggtaatactg gaacaggact agcaatagct tgtgcatgta aaggatataa
     1621 atttatagcg tgtatgtcaa aaggaaattc tatggaaaga gcaagaatga tgaaagcttt
     1681 aggtgctgaa gtagttcttg tagaccaaat gcctaattca gttcatggac aggtatctgg
     1741 tgaagatttg gcacttgtag aaattgaggc tcaaaaaata gcaaaagaaa gaaatgcatt
     1801 tagagcagac caatttaatt tagaagcttg taatcatgca catgaaaagt atacagcaga
     1861 agaaatgtgg gaacaattgg atggaaatat tgatgtattt gtagattttc ttggaagtgg
     1921 tagtactttt gcaggatgtt caaaaacact taaaaaacat aattcttcta tcaaatgtta
     1981 tgttgttgaa cctgaaacag cagcaattta ttcaggtaaa gaaataactg accaagggca
     2041 taaaatacaa ggtggaggat attctatgga tttgccatta gtagacaaga aacttattga
     2101 tggttatatt caagttacag acgaggaggc aactgatgta gcaagaaaat tagctaaatt
     2161 agaaggtgta tttgcaggat tttcttcagg ggcaaatgta tgtgcagcaa ttaagttgtt
     2221 aaagagcagt gaaaaaggaa aaaatatagt tttaactctt aatgatagtg gtttaaaata
     2281 tttaagtact gatttatatg aagaattgta ataatagcac aatagttatg caatgttttt
     2341 taaattaagt atatagattt aaattataaa aagtatctca atgtaaattt tgaaagttat
     2401 aaaggagata cttttttatt ttgtaaatat ggagtatcct acttataagt attaagctat
     2461 atagatattg atgattagct atgcaataaa aaagagtatg tgtttttgca tttatacatc
     2521 ataacttgga ataatacata ttaatgttct aaatgtat
//
LOCUS       DAEPID010000173         2533 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.177, whole genome shotgun sequence.
ACCESSION   DAEPID010000173 DAEPID010000000
VERSION     DAEPID010000173.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 2533)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2533)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2533
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.177"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            636..2432
                     /locus_tag="KR257_003783"
     CDS             636..2432
                     /locus_tag="KR257_003783"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002594337.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="group II intron reverse transcriptase/maturase"
                     /protein_id="HBH0032431.1"
                     /translation="MKPTMEILTKLQENSKKNHDEVFTRLYRYLLRPDIYYVAYQHLY
                     SNKGAGTKGVTDDTADGFSEIYIENIIEALKNEMYQPKPVRRTYIKKSNGKMRPLGLP
                     VFTDKLIQEAIRMILEAIYEPIFSDYSHGFRPARSCHTALAQIKKEFTGARWFIEGDI
                     KGCFDNINHAVLVEIINQKIKDARFLKLIRSFLKAGYMEDWKYHKTYSGCPQGGIISP
                     ILANIYLNELDRHVMKIKKEFDVATKARYTPEYTKLVGLRQRLHNKIKNSNGIEREKL
                     IEEYKSATAQMLKLPAKQCDDKKIKYVRYADDFLIAVNGNRQDCEKIKQELTEFISTT
                     LKMELSQEKTLITHSNTPARFLGYDVRVRRDQQIKPKGKFKTRSMNNKVELSIPFKDK
                     IEKFLFSNGIVKQRSDNGKLEPIHRPQLLNRTDLEIVTIYNAELRGICNYYGLASNFN
                     KLIYFNYLMEYSCLKTLAGKHRSKVSKIRAMYKDGTGKWAIPYETKTVIKKMYFANYA
                     DCKGKKFTDIVPQTAKNYSHDVTTLESRLKAKICEVCGCTESDRYEIHHVNKVKNLKG
                     KSEWEKIMIAKRRKTIVVCHKCHMAIHHGEKK"
BASE COUNT          971 a          433 c          528 g          601 t
ORIGIN      
        1 ttagaagtag attaaagaaa gggggacaga aaaaaaaggc actaccccgt aagataacac
       61 gggaaaccac ctgcctaacc gaaaggtgaa aactgtacgg gaaaatagca cggcaggaaa
      121 gcagaaagtt gttcaaagac aatagagcac gactgaactg caaggttaag tgaatatgag
      181 gataaaacta gatttgttga atgtgagttc caaacctctg ttacgtgtgg acacaggaaa
      241 cttgtctgaa acctgtggta tgagtaacgc tgaaaataaa tgcctttcag tgggttatca
      301 attaactcat acggtacgct ggagaaccag tagtaacgga acgaaagcat atccgacaat
      361 tcacaccagc ctactacttt cgtcaactgg agattaccta aaccagaatg cctacaatgg
      421 ctatgtgtaa tgctcttgta gtgataaatc acaaggctat gctaagtgag atgacgctga
      481 aaatctggca aggtaacgga gctttcatag tagtctgaga accctgaaaa gacagggaaa
      541 gccgtaaaat cggatacggg aaaaccgttc acatggcgaa ggaaagcagt cttagcgaat
      601 taaaattaga aattgattag ggaggaaaac ctcaaatgaa accaacaatg gagattttaa
      661 ccaaattaca ggaaaattca aaaaagaacc atgatgaagt atttacaagg ctctatcgat
      721 atttactccg tccagatata tactatgttg catatcaaca cctctactcc aacaaaggag
      781 caggaacaaa gggtgtaaca gacgacacag cggacggttt tagcgaaata tatattgaaa
      841 atatcattga agccttaaaa aatgaaatgt atcaaccaaa accagtaaga cgtacataca
      901 tcaaaaaatc aaatggcaaa atgcgtccct taggactgcc tgtctttact gataagctga
      961 tacaggaagc aatacgcatg atattagaag caatctatga gcctattttt tcagactact
     1021 ctcacggttt ccgaccagca agaagttgtc atactgctct tgctcaaata aaaaaagaat
     1081 ttacaggagc acgctggttt atagagggcg acataaaagg gtgctttgat aacatcaatc
     1141 atgcggtact tgtggaaatt atcaatcaga aaattaaaga tgcacgtttt ctgaaactca
     1201 ttcgttcatt cttaaaggca ggttatatgg aagattggaa ataccacaaa acatatagcg
     1261 gttgccctca aggtggcatc atttcgccta ttcttgcgaa tatctacctt aatgaattag
     1321 accgtcacgt aatgaagata aagaaagagt ttgatgtggc aacaaaggca cgttatacac
     1381 cagaatatac aaaactggta ggactacgcc aaagattaca caacaaaatt aaaaatagca
     1441 acggtataga aagagaaaag ctgattgaag aatataaatc tgcaacggct caaatgctta
     1501 aactaccagc gaagcaatgt gacgacaaga aaataaaata tgtgcgttac gctgatgatt
     1561 tcctaatagc tgtgaatggc aatcgacagg attgtgagaa gattaagcaa gaacttacag
     1621 aatttataag taccacatta aaaatggaac ttagtcaaga aaaaactctg attacacaca
     1681 gtaatactcc tgctcgtttt ctcggatatg atgtcagagt acgccgtgac cagcagatta
     1741 aaccaaaagg aaaattcaaa acccgttcta tgaataacaa ggtggaattg agtattccat
     1801 tcaaagacaa gatagagaaa tttttatttt caaatggaat tgtaaagcag aggtcagaca
     1861 atgggaaatt agaacctata caccgaccac aactgcttaa taggacagat ttggaaatag
     1921 tgactattta taatgcagaa ttaagaggta tctgtaatta ttatgggttg gcaagcaatt
     1981 ttaacaagct aatctatttc aattatctta tggaatatag ctgtttgaaa acacttgcag
     2041 gaaagcaccg ttccaaagtt tctaaaatta gagctatgta taaagacggt acaggcaaat
     2101 gggctattcc ttatgaaact aaaacagtaa taaagaaaat gtattttgcg aattatgctg
     2161 actgcaaagg aaagaagttt actgatattg ttccacaaac agctaaaaat tattcccatg
     2221 acgtaacaac attagaaagc cgattaaagg cgaagatatg tgaagtatgt gggtgtacgg
     2281 aaagtgacag atacgaaatt catcatgtaa acaaggttaa aaaccttaaa ggaaaatcag
     2341 aatgggaaaa gataatgata gccaaaagac ggaaaacaat cgtggtatgc cacaagtgtc
     2401 acatggctat acatcatggc gaaaagaaat aacctgtaac ggagcaaaga tggagagccg
     2461 tgtgcattga gaaatgcaag cacggttcgg ggagaggact gcacaaacct accctagaaa
     2521 taaggaaagg cgg
//
LOCUS       DAEPID010000174         2520 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.178, whole genome shotgun sequence.
ACCESSION   DAEPID010000174 DAEPID010000000
VERSION     DAEPID010000174.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 2520)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2520)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2520
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.178"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            10..483
                     /locus_tag="KR257_003784"
     CDS             10..483
                     /locus_tag="KR257_003784"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729469.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HBH0032432.1"
                     /translation="MFKEYLIRELKEDDIKNALDLIWNVFEEFESPDYCDEGITTFHQ
                     FIEYNSIIEKIKEKTLFFWGCFDSKKLIGVLAIRNLNHICMLFVDKNYHKHGVAKKLM
                     TTGIQYCICNKFNLTEITVNSSPYAVEVYHKLGFKDTAVEQIVDGIRFTPMKLLI"
     gene            complement(852..1409)
                     /locus_tag="KR257_003785"
     CDS             complement(852..1409)
                     /locus_tag="KR257_003785"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435154.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="HBH0032433.1"
                     /translation="MRVSREIVIQATSDIVNKDGLNKVSLKVIAEKLGIRTPSLYNHI
                     ESLDDLLLEVAHKGMREMNSQMIKAAIGNFGDTAIKCISIAYFNFIISNPGVYETIQW
                     ATWHGNNETLEIFDEYKSLLEKLILSCNLNTKNTGEVLNLIMSVLHGYSTLQLGKSFL
                     SKEEAIKGLVDSIDTVLLGIHKKYD"
     gene            1667..2365
                     /locus_tag="KR257_003786"
     CDS             1667..2365
                     /locus_tag="KR257_003786"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729468.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha/beta hydrolase"
                     /protein_id="HBH0032434.1"
                     /translation="MEKKYFEIHGVPSILWGNPSSKLYIYIHGQCGNKEEAEAFANIA
                     VPHECQVLSVDLPEHGERKREKNSFNPWHVVPELVSIMEYAKCHWNQISLYANSIGAW
                     FSMLSFEKENLRECIFVSPILDMQQLISNMMLWANVSEEQLKHELIIPTSFGHTLSWE
                     YLQYVKQHPITQWNIPTKILYGKHDELTEIGVVEKFVEKFNCNLTIVENGKHWFNTPQ
                     ELNSLYEWLNTLVK"
BASE COUNT          941 a          323 c          302 g          954 t
ORIGIN      
        1 ttgtttataa tgttcaaaga atacttaata agagaattaa aagaagatga tattaaaaat
       61 gcattagact taatctggaa cgtatttgaa gaatttgaat ctccagatta ttgtgatgaa
      121 ggaattacga catttcatca atttatagaa tataactcta ttattgaaaa aatcaaagaa
      181 aaaactctct tcttttgggg ttgttttgac tctaaaaaac ttattggagt cttagctatt
      241 agaaatttaa atcatatatg tatgttattt gtagataaaa actatcataa acatggtgtt
      301 gcaaaaaaat taatgactac aggcatacaa tactgtattt gtaataaatt taatttaact
      361 gaaataactg taaattcatc accttatgct gttgaagttt atcataaatt aggatttaaa
      421 gatactgctg ttgagcaaat tgttgacggt atacgtttta cacctatgaa attgttaata
      481 taataaatta aataaaaagc aaagtctctt aaatatttta tagttacttt gcttttaaac
      541 caagatttaa aataatacta tcttttttgt tttttaataa tatactttaa aatccttact
      601 aatatgaact ataatttatt ttttgatatc ctttttgatt aacatataaa ttaattcaat
      661 tattaaacat aaactatgtt gtttctcttt atatctcttc tttgtaaaca atattgggca
      721 tttgaaaata aatattctta aaatatactg ttctcctgtt gattttcctt tggtacaaat
      781 gataaaaatt taatttacat gccccataat gaagtgttca ataaataagt taaaataatt
      841 tatttacctc cttaatcata ttttttatga atacctaata acacagtatc aatagaatcg
      901 actaaacctt ttatagcttc ttctttactc aaaaatgatt tcccaagttg caaagtcgaa
      961 taaccatgaa gtacactcat tattaagttt aatacttcac ctgtattctt tgtatttaga
     1021 ttacaagaaa gaataagttt ttctaataag gatttatatt catcaaagat ttctaatgtt
     1081 tcattatttc catgccaagt agcccactga attgtttcat aaacaccagg attagaaatt
     1141 ataaaattaa agtatgctat acttatacac tttatagctg tatctccaaa atttccaata
     1201 gccgccttta tcatttgact attcatctct ctcattcctt tatgagctac ttcaagtaat
     1261 aaatcatcta gactttctat atgattgtac aaagatggtg tacgtattcc tagcttttct
     1321 gcaataactt ttaaagaaac tttgttaagc ccatctttat taactatatc tgatgtagct
     1381 tgtataacta tttctctact aacacgcatg attttccctc tttcatttaa aattaattac
     1441 tttattagtt taactaatct aattagtttc gtcaattatt gtaatttata aaattcttta
     1501 tactattata aaatcttgac agtttaatta taatttaata taatactaat taaattagtt
     1561 ttaatactaa tataattagt attatattaa attctatatt acaacattat tttatagttt
     1621 gattaattta ataatcacta atatatcaaa ctgaaaggag atttttatgg aaaaaaaata
     1681 tttcgaaatt catggagttc cttcaatcct ttggggaaat ccttcaagta aattatatat
     1741 ttacatacat ggacaatgtg gcaataaaga ggaggctgaa gcttttgcta atattgcagt
     1801 tccacatgag tgtcaagttt taagtgttga tttgcctgaa catggagaac gtaaaagaga
     1861 aaaaaattca tttaacccat ggcatgttgt tccagaatta gtatctatta tggaatatgc
     1921 aaagtgccac tggaatcaaa tttcgttata tgcaaatagc attggagcat ggtttagtat
     1981 gttaagcttt gaaaaagaga acttaagaga gtgtattttt gtatctccaa ttctagatat
     2041 gcaacagctc atttcaaata tgatgctctg ggcaaatgta tcagaagaac agcttaaaca
     2101 tgaactaatt atcccaactt catttgggca tactctttca tgggaatatc tacaatatgt
     2161 aaaacaacat cctatcactc aatggaatat accaacaaaa atattatatg gtaaacatga
     2221 tgaacttact gaaatcggtg ttgtagagaa atttgtagaa aagtttaatt gcaaccttac
     2281 tattgtagaa aatggcaaac attggtttaa cacaccacaa gaattaaatt cattatatga
     2341 atggttaaat actttagtta aataaaaaat aattatatta ttaatatgat taaattattt
     2401 ataaatgtta tttaattaat tttattttag cattattaaa ataactacat aaagaataaa
     2461 ttagttatta ttaaagaaat taaaagtata tagagtatta ataatttttt aataattagt
//
LOCUS       DAEPID010000175         2247 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.179, whole genome shotgun sequence.
ACCESSION   DAEPID010000175 DAEPID010000000
VERSION     DAEPID010000175.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 2247)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2247)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2247
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.179"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            complement(178..1470)
                     /gene="brnQ"
                     /locus_tag="KR257_003787"
     CDS             complement(178..1470)
                     /gene="brnQ"
                     /locus_tag="KR257_003787"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438233.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="branched-chain amino acid transport system II
                     carrier protein"
                     /protein_id="HBH0032435.1"
                     /translation="MGEKQINFKDVIVIGFALFAMFFGAGNLIFPPYLGVLSGSSWLI
                     AFIGFLFADGGLALLAVIAATKFNGDTSKMFSRAGKGLSIALGCAMVICIGPLLAIPR
                     TAATTYEMGILPTIGSGISPVIFSIVFFALVLVLTIRPSKVVDIVGSILTPALLIALA
                     VLIVKGIISPLGEIRDSSLIQNVFAEGITQGYQTMDALAASVFASIIIMSVIAKGYTG
                     EKEKMKATISAGVIAVIGMALVYGGLCYLGATVSQQYGQDVQQTALIVAITAALLGTT
                     GKILLAIIVALACLTTAIGLSSAAGQYFSTLTDGKLKYEHIVIVVCVFSAIISNFGVS
                     TIIQFSSPILSMVYPATITLVILALFSNKIKNDNVFKCAAYMALLVSVLTVATSFGVK
                     IPLVNSLPFASLGFNWIVPVVIAGIIGNFIPSKSSKTA"
BASE COUNT          744 a          368 c          250 g          885 t
ORIGIN      
        1 cttttttatt ttattatctt tataaatcat actactccaa aaataaattt ttaaatttat
       61 caaataggat taataatgtt cttttatcta caataattta ataattcttt taaatataaa
      121 aaggaattgc ctatataatt taaaggcaat tccataatta tcaattagtt tttattatta
      181 tgcagtttta ctgcttttag atggaataaa gtttcctatt attcctgcta ttacaactgg
      241 aactatccag ttaaatccta atgaagcaaa tggtaagcta ttaactagag gaatttttac
      301 accaaaactt gttgcaactg ttaatacact tactaataat gccatgtatg cagcacattt
      361 gaacacgttg tcatttttaa ttttattact aaataatgct agtataacta gagttatagt
      421 tgctggatat accatactta gtataggaga agagaattgt attattgtac ttactccaaa
      481 gtttgatatg attgcactaa atacacaaac tactataact atatgctcat actttaattt
      541 tccatctgta agtgttgaga aatattgacc agctgctgaa gaaagaccta tagctgttgt
      601 taaacatgct aatgcaacta taatagccaa taaaatttta cctgtagttc caagtaaagc
      661 tgctgttatt gcaactatta aagctgtttg ttgaacatct tgtccatatt gttgagacac
      721 agttgctcca agataacata atccaccata aactaatgcc attcctatta ctgcaattac
      781 acctgcactt attgtggctt tcatcttttc tttctcacct gtataacctt tagctattac
      841 tgacatgatt ataattgatg caaatacact agctgccaat gcatccattg tttgataacc
      901 ttgagttata ccttctgcaa atacattttg tattaaagaa ctgtctctta tttctcctaa
      961 tggagatatg atacctttaa ctattaatac tgctaaagct ataagtaaag ctggagttaa
     1021 tattgaccca actatatcta caacttttga tggtcttatt gttaaaacca atactagagc
     1081 aaagaatact atagagaata ttactgggct tattccagaa cctattgtag gtaatatacc
     1141 catttcataa gttgttgctg ctgttctagg tattgctaaa agtggcccta tacagattac
     1201 cattgcacat cctaatgcaa tacttaatcc tttgcctgct cttgagaaca tcttcgatgt
     1261 gtctccattg aacttagttg ctgctataac tgctaataat gccaaaccac catctgcaaa
     1321 aaggaatcct atgaaagcta ttagccaact acttccagat aaaactccta gatatggagg
     1381 gaagattaag ttccctgcac caaaaaacat tgcaaatagt gcaaatccaa ttacaattac
     1441 atctttaaaa ttgatttgtt tctcacccat ttaaagcacc cccatttgaa ttttactacc
     1501 ttttactaaa aaataagtcc aatctcttca ttaaatgaaa accttttgac gagattttat
     1561 ttaattatac atttttgact taaatttgtc aattatgttt cataatttat aaaatcttca
     1621 caatatttaa tacaactttc ttaattaaac aaaatcaacc tgtatacttt aaacacagtt
     1681 ggttttttgt tttttctcta atttttcttg ataaaattaa ttattctgaa taattaaaat
     1741 attaagattt tttagattat tcgatttgtt attaagtgta ttgctttata tactgtatat
     1801 atcactctcc ttttttacat tcatataatc tttttaattc aatttaaatt ttaaatattt
     1861 tgtgtttatt atataatctg aaaaaaaagc agtcaatagc atttttaatt tttttaattt
     1921 tcaaaattat gattcttaaa aaatcgtttt ccttttgtca tagcacctat ttacgttaat
     1981 tcttgtagta ttttgtattt attttgctaa attgacagtt aactttattc gttttttatt
     2041 ctatttatgt agatttgcct cttgtttttt agtcttaaaa tcattttttc tgaaaattcc
     2101 ttattatgat ttatcaactt atttttcttc atatcaatta ctttctaact tccaacttac
     2161 ttaaactttg cagttgctag tattcacgtt tacatactta tctgtcataa ttaactaaaa
     2221 attcttaata tatctctcaa tgaaaac
//
LOCUS       DAEPID010000176         2187 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.181, whole genome shotgun sequence.
ACCESSION   DAEPID010000176 DAEPID010000000
VERSION     DAEPID010000176.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 2187)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2187)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2187
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.181"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            438..2057
                     /locus_tag="KR257_003788"
     CDS             438..2057
                     /locus_tag="KR257_003788"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423615.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Na/Pi cotransporter family protein"
                     /protein_id="HBH0032436.1"
                     /translation="MNIVISLIGGLGLFLYGMSLMGEGLQKSAGDKLKKIIELLTSNV
                     VMGVLVGTVVTGIIQSSSATTVMVVGFVNAGIMNLSQAIGVIMGANIGTTVTAQLVSF
                     NLEGIAPIALGIGILFYLFTSNQKTKHLSEILIGFGILFTGMEFMKDAVAPLAEYKAF
                     TDALLYFSKNPVLGILAGFAITGIVQSSSASMGMLIALASQGILPLSSALPILYGDNI
                     GTCVTSLLSSVGASRNARRAAVMHLSFNVIGTIIFMLVLNKPISAIVTHFDPTDTARQ
                     IANAHTLFNLTNVIILLPFSKYIVKLANRLIPIKETESEIVNNTKYLDERMFSTPSIA
                     LGNTVQEVVRMGHKATNSLEHSIAGFLNKSNEDINKAFESEKVVNKLQKDILNYLLKL
                     SKEPLRDDEHFRTDLLFNTVNDIERVSDHAENIAELAMSVKEMNISFSDSAIREIYEI
                     YNKTITNFKDALIVLDVKDFELANKVLEVENEVNYLEKTFRNSHMIRLNNGSCTIDAG
                     VLYLDLLTNLERISDHSTNIVKQVLKLKQKI"
BASE COUNT          819 a          257 c          324 g          787 t
ORIGIN      
        1 ttaaaaaaag acttgtctat tttagacgtt gctgtactaa ttggattcaa tagtcaaaat
       61 tactatagta taatttttaa aaagtttaat aactttacac caattgaata taaaaatatt
      121 tataactaaa aaatatcatt ctaaaaggat gttatttttt tacatatttt ttacaattat
      181 agttaattct ttgttaaatt gtttgtacat aaaatactaa aaatctaagt tcaagtattt
      241 aaattgctat atatcataaa ttttctaaaa ttaacaacaa cttaaaaatt taacattctc
      301 ttaacgtata cttaacaaaa cattaatatt tttattgaca aaatttgtta ttctatatta
      361 tggaaacaat aaattttagt taataaagtt tataattcag ataaaaaaat tattaatttc
      421 ttaagggagg aaatatcgtg aatatagtaa ttagccttat cggtggactt ggactttttc
      481 tttacggaat gagtttaatg ggagaaggtt tacaaaaatc agcaggagac aaattaaaaa
      541 aaattattga actcttaaca agtaatgttg ttatgggtgt actggtaggt acagtcgtta
      601 caggtattat acaaagttca agtgctacta ctgttatggt tgtaggattt gtaaatgcag
      661 gtataatgaa tctaagtcaa gctattggtg taataatggg ggcaaatata ggtactacag
      721 ttactgctca attagtttca tttaatcttg aaggaattgc accaattgct ttaggtatag
      781 gtattttatt ctatttattt acatcaaatc aaaaaacaaa gcatttatct gagatactta
      841 taggttttgg tatattattt acaggaatgg agtttatgaa agatgcagta gctccacttg
      901 ctgaatacaa agcattcact gatgcacttt tatattttag taaaaatcct gtattaggta
      961 tattggcagg atttgccata actggtattg ttcaaagttc aagtgcatct atgggtatgt
     1021 taatagcact agcttctcaa ggaatacttc ctctatcatc tgctttacct attctttatg
     1081 gagataatat aggtacttgt gttacttcac ttttatcaag tgttggtgca agtagaaatg
     1141 ctcgacgtgc agctgtaatg catttaagtt ttaatgtaat tggtacaata atatttatgc
     1201 ttgttttaaa taaacctata tcagccatag ttactcattt tgacccaact gatacagcta
     1261 gacaaatagc aaatgcacat actttattta atcttacaaa tgttataata ttattaccat
     1321 tttctaaata catagttaaa ttagcaaata gacttatacc tattaaagaa actgaatcag
     1381 aaatagtaaa taatactaag tacttagatg aaaggatgtt tagcactcca tctatagcac
     1441 ttggtaatac tgtacaagaa gttgtaagaa tgggtcataa agctacaaac tctttggaac
     1501 attcaattgc aggattttta aataagagca atgaagatat taataaagct tttgagtcag
     1561 aaaaagttgt caataagtta cagaaagata tattgaacta tttgttaaaa ctttctaaag
     1621 aacctcttag agatgatgaa cactttagaa cagatttgct ttttaatact gtaaatgaca
     1681 ttgaaagagt ctctgaccat gcagaaaata tagctgaatt ggccatgagt gttaaggaaa
     1741 tgaacattag tttttctgat agtgcgataa gagaaatata cgaaatatac aataagacaa
     1801 ttactaattt taaggatgcc ttaatagttt tagatgttaa agattttgag ttagcaaata
     1861 aagttttaga agttgaaaat gaagtaaatt atttagaaaa aacttttaga aattcacata
     1921 tgattagact aaataatgga agttgtacaa ttgatgctgg tgtactttat cttgacttac
     1981 ttactaatct agaaagaatt tctgaccact caacaaatat agtaaaacaa gtactaaaac
     2041 ttaaacaaaa aatatagtga ttatttttat atataatctt aatcaatgag aagtaagaag
     2101 ctatagataa tgcttatatc atttatggtt tcttattttt tatgtaatac tcaaattttt
     2161 atagtattct cttattatta aacaatt
//
LOCUS       DAEPID010000177         2142 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.182, whole genome shotgun sequence.
ACCESSION   DAEPID010000177 DAEPID010000000
VERSION     DAEPID010000177.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 2142)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2142)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2142
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.182"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            complement(27..941)
                     /locus_tag="KR257_003789"
     CDS             complement(27..941)
                     /locus_tag="KR257_003789"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420014.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF2935 domain-containing protein"
                     /protein_id="HBH0032437.1"
                     /translation="MIDNQKYVILSLELHLFFSRIMKEHALFLEAGFTNKNYNLAMEA
                     DHYKKQFEDLLSYTVSASNGIIRPDILYSEELVTTLTSVAEQKTEEFTGIEINKNITT
                     RELNLQSGVNPQVGQDLVNYVAQLNSDAIRLLDGLINFKERVLDGVLSCTIFTSNYPL
                     LLEHIIHEANLYRYYVVDLENKIDIESKNAKEIELFWDHIMMEHALFMRGLLDPSEGE
                     LINTSNDFAIKFNELIEKTNEMTDSNIKNITEETLNETVEFKDFKEAGASGIEQCKIK
                     SIILPLLADHVLREANHYIRILESYKNM"
     gene            complement(1773..1955)
                     /locus_tag="KR257_003790"
     CDS             complement(1773..1955)
                     /locus_tag="KR257_003790"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420016.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0032438.1"
                     /translation="MFKDKIDECVHIMTAYIASLKEYYSFIETQIGDFIKKYGEDVVE
                     LCLHRVMILLCECGLA"
BASE COUNT          778 a          274 c          270 g          820 t
ORIGIN      
        1 aagattattt taaaagtaat ttttaattac atgtttttat aactctccaa tattctaata
       61 taatgatttg cctctcttaa aacatggtct gctaaaagtg gtaatattat agattttatc
      121 ttacactgtt ctattcctga tgctcctgct tctttaaaat ctttaaactc aacagtttca
      181 tttagagttt cttctgtaat gttcttgata ttagaatcag tcatttcgtt tgttttttca
      241 attaattcat taaattttat agcaaaatca tttgaagtat ttattagttc accttctgag
      301 gggtctagta atcctctcat aaacagagca tgttccatca taatatggtc ccagaataat
      361 tctatttctt tagcgttttt tgactcaata tctattttat tttcaaggtc aactacataa
      421 taacgatata aatttgcttc atgtattata tgttcaagaa gtagagggta gtttgatgta
      481 aatatagtac atgatagtac accatctaag actctttctt taaaattaat aagcccatca
      541 agtaatctta ttgcatcaga gttaagttga gctacatagt tcactaagtc ttgaccaact
      601 tgtgggttta caccactttg tagatttaat tctcttgtag tgatgttttt gtttatttct
      661 atccctgtaa actcttctgt tttttgttct gcaactgatg tgagagtagt tacaagctct
      721 tctgaatata atatatcagg tctaattata ccattactag cactaacagt gtatgataat
      781 aaatcttcaa attgcttttt atagtggtca gcttccatag caagattata atttttattt
      841 gtgaatcctg cttctaaaaa aagagcatgc tctttcataa ttcttgaaaa aaataaatgt
      901 aattctagtg ataaaataac atatttttga ttatctatca taatttcctc cctttagaaa
      961 gtatcctatt tataatactt tattcgtaat atttaaattt atgtatatta taaataaatt
     1021 aactaaattc aattgctact aatatcaaca gtttttatta agttatgggc gaaaaaatta
     1081 tcttactgtg tttcttatta gatatagata taatgattta aggtacttgt tggctattat
     1141 ttattaagag tacaagtaat actagaaatt tttatgagaa ttatgtaatt tacaagtatt
     1201 attttgatac aaaacaaatg ttttttgtaa aacaagaact tttatagtaa aaaatgaata
     1261 aatatgaagc aagcataatt ttataccaca acaattatta attctaatag ctgcacttaa
     1321 tgctttaggt atgggattta aaaagtataa aaaattaagt gataaatata ttccattata
     1381 ttgcttgtgc ttggagtagt attttctgta tagatgttag gatttaatcc aacttctatt
     1441 ttacagggga ttctatgctg gggtgtttca attggattaa attaagtatg caaacaattt
     1501 caagacaatg ataaataatt ggatgtgtga taggaatatc aacaaaaaac attattaaaa
     1561 agaattattt tatttataaa ataaaacaag taataagaat aaataaggag caactaaaat
     1621 gatttaaata tactagaatt aaaaagagaa tgtaaagttg tctagtaatg gatgtaaaat
     1681 attttaaacg ataagctatg aaattgatat attaaaatgg gtaagaagaa tattatatag
     1741 gattcttctt acccatttta ataaatttaa ttttatgcca aaccacattc gcatagtaga
     1801 atcatcactc tatggagaca taactctaca acatcttctc catatttttt aataaaatca
     1861 ccaatttgag tttctatgaa tgaatagtat tcttttaaac tagcaatata tgcagtcatt
     1921 atatgaacac attcatcaat cttatcttta aacacaacta atccccctaa aaaacgaaaa
     1981 ataaaaatat tcagtaaata gcagatatta tttcactcat aaatctatat agtatgatat
     2041 attgcttaga tatattttac aagtggatat gtaaaactgg ttattataat cgcaaaactg
     2101 gataaacttt cattcttaaa agaaaattta tccagtttaa ag
//
LOCUS       DAEPID010000178         2133 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.183, whole genome shotgun sequence.
ACCESSION   DAEPID010000178 DAEPID010000000
VERSION     DAEPID010000178.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 2133)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2133)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2133
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.183"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            complement(185..814)
                     /locus_tag="KR257_003791"
     CDS             complement(185..814)
                     /locus_tag="KR257_003791"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421905.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glutamine amidotransferase"
                     /protein_id="HBH0032439.1"
                     /translation="MKNRKVYMYVFDTMSDWEVAYLTAELNTGRYFKKGLKPLKVITV
                     GIDKNPIITMGGLKVLPEITVDEFNMESKDLLILPGGNTWLSMNHEIILEKVKEALIQ
                     DSIVAAICGATLGLAKKGLLDVRNHTSNDLEFLKMVIPNYSGEKYYKTESVVSDENLV
                     TASGIAPLEFTFQVLKLLDVFESEALNSWLNLYKTHDSKYFFELMNCNK"
     gene            complement(893..1855)
                     /locus_tag="KR257_003792"
     CDS             complement(893..1855)
                     /locus_tag="KR257_003792"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017561613.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="WYL domain-containing protein"
                     /protein_id="HBH0032440.1"
                     /translation="MAKIDNMMSILWMLNSDKKITAKQIAEKLEINIRTVYRYIDVLS
                     ASGVPIISDTGHNGGYSLLNNFTKAPLFFDIEEQKSLLHAALFAKKEGYFLDEALDKS
                     ILKLKMYSNQNQEDILTNHLRALEVIKPIGKVSIESVLKKLENSILKELSVEINYHAG
                     RKAKSKYRIINPYGIVHWNNNWYVVAFCNMRNEVRSFRVDRISEIIETSNTFNRPTEF
                     SASEFFIKGIIPEIKDEQNIIQLVVEGSIDSLDSLSQHWFLGHYLKERTPNKIIFMLE
                     EEVICKYIPNILLPYRKTIQVIEPLSLRKKIIEDLLELIDYYQI"
BASE COUNT          686 a          344 c          227 g          876 t
ORIGIN      
        1 taatttttta acacttttct gttggctata tagaaagtgg tttagaattt aaatttaaat
       61 aaaatttaaa ttcaccaaaa agaaatctat attagaaacc actactctat tccaccagat
      121 tgtaattttt tgttctttat atcacaatgc tataccatat taaattgaaa aataaatttt
      181 aaatttattt gttacaattc attaattcaa aaaaatattt tgagtcatga gttttgtaaa
      241 gatttagcca tgaatttaat gcttctgatt caaaaacatc taaaagtttc aatacttgaa
      301 acgtaaattc caacggagcg attcctgaag ccgtaactaa attttcatca ctaactacag
      361 attccgtttt ataatatttt tctccagagt aatttggtat taccatttta agaaactcta
      421 agtcattact tgtatgattt ctaacatcta atagcccttt tttagctagg cctaatgtag
      481 ctccacatat ggctgcaact atagaatctt gtattaaagc ttctttaact ttttctaata
      541 ttatctcatg attcatggat aaccaagtat ttccccctgg caaaattaat aaatccttac
      601 tttccatatt aaactcatca actgtaattt caggtaaaac ttttaaccca cccattgtta
      661 taataggatt tttatcaatt cctacagtaa ttacttttag tggctttaat ccttttttaa
      721 aatatcttcc tgtatttaat tcagcagtta aatatgccac ttcccaatct gacatagtat
      781 caaatacata catatatact tttctatttt tcatcttttt tactccttat gtaattaatt
      841 tatatatcta attataaaat aacttaactg acatattcag tcagttaagc tattaaattt
      901 gataataatc aattaattct agtaaatctt caattatttt cttcctaagg cttagtggtt
      961 caattacttg tattgtcttt ctataaggta aaagtatatt tggtatgtac ttgcatatta
     1021 cttcctcttc gagcataaat attattttat taggtgttct ttctttcaag tagtgcccta
     1081 aaaaccaatg ttggcttaaa ctatctaaag aatctatact cccttctaca actaattgaa
     1141 ttatattttg ttcatctttt atttcaggta taattccttt tataaaaaat tcacttgctg
     1201 aaaattctgt cggtctgtta aatgtatttg atgtttctat gatttcacta atcctatcca
     1261 ctctgaaact acgtacctca tttctcatat tacaaaatgc aactacgtac caattattat
     1321 tccagtgaac aattccatat ggatttataa ttctatattt tgattttgct ttacgacctg
     1381 catgatagtt gatttctaca gatagctcct ttaatatact attctccaat tttttaagta
     1441 ctgattctat agacactttc ccaattggtt ttattacttc aagggctctt aagtggtttg
     1501 ttaaaatatc ttcttggttt tgatttgaat acatttttaa ctttaatatc gatttatcta
     1561 atgcttcgtc taagaagtat ccttcttttt tagcaaatag agctgcatga agtagagatt
     1621 tttgctcttc tatatcaaaa aaaagaggtg ctttagtaaa attatttaaa aggctatacc
     1681 caccattatg acctgtatct gaaattatag gtactccact cgcagaaagt acatcaatat
     1741 atcggtacac tgttcttata tttatttcta atttttcagc tatctgtttt gctgtaattt
     1801 ttttgtcaga gtttaacatc cacagtatag acatcatatt gtcaatttta gccatgtagt
     1861 ttcacctctt tctatttgtt atataaagtt attatataac tttttgattg attttttaca
     1921 aaaaaacatt agtaaactgc taataattta tactaagatt tatttcaaat atttatagat
     1981 agtctttttc tatagttaag ttatccatta aattacatag tagtatatcc attttagttg
     2041 atatattttc agctacctcc cttgaatatt attacaataa gtctaaatct tctttcttcc
     2101 ataaatatat tatgaggaaa gactatcatc ttt
//
LOCUS       DAEPID010000179         2099 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.184, whole genome shotgun sequence.
ACCESSION   DAEPID010000179 DAEPID010000000
VERSION     DAEPID010000179.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 2099)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2099)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2099
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.184"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            119..493
                     /locus_tag="KR257_003793"
     CDS             119..493
                     /locus_tag="KR257_003793"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424232.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GntR family transcriptional regulator"
                     /protein_id="HBH0032441.1"
                     /translation="MNIVISNSSGKPIYEQITTQIKSMIISGELPEGSALPSMRLLAK
                     ELRISVITTKRAYSDLERDGFIETVTGKGSFVSSKNMDFVKEEQFRLIEEYLQKAVDT
                     AKSSDITYDELKDILFLLYKGE"
     gene            490..1353
                     /locus_tag="KR257_003794"
     CDS             490..1353
                     /locus_tag="KR257_003794"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435188.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBH0032442.1"
                     /translation="MISMDAITIKNLNKTYKDFSLQDISFSVPKGSVMGFVGENGAGK
                     TTTLKAILNLISYDSGNIEIFGLDSKKNEKEIKEQIGVVFEGSNFHENLNTDHVSKIM
                     SKIYKNWNDTLFKDYLKKLRVPDNKLIKEFSKGNKMKLSIAVALSHKPKLLILDEATS
                     SLDPIVREEILDIFLDFIQDEEHSIILSSHITSDLDKIADYITFIHKGKIVFSENKDE
                     LIDTMGVLKCKPSDFDNLSREDYSYYRKSQFGYEVLLKDKHRFISRHPNCIVDNTSIE
                     EIMLFYVRGDK"
     gene            1353..1991
                     /locus_tag="KR257_003795"
     CDS             1353..1991
                     /locus_tag="KR257_003795"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435186.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC-2 transporter permease"
                     /protein_id="HBH0032443.1"
                     /translation="MKGLILKDLLNLKGNIKFILLFIIMFGFMSSLGDGNVNNFIGVI
                     IVLCTTMIVSTFSYDDLNKWDSYVLTMPINRNDIVLSKYLTMLIFSFIGVLVSLIVSV
                     TIGYFKNTLILNETLLINALILSISVCFGSLILPLIYKFGTERARLLMILCFLVPTLA
                     LLVFKSILENISSPISIEIILNTLVYSLPFVAILLFVISYFISSKIYSKKEV"
BASE COUNT          796 a          214 c          314 g          775 t
ORIGIN      
        1 attacattta ttaaatgtat aatattggca attagttttt tctaaaatca gttgacatat
       61 tatatatata tttatataat gtgtatatac tatatataca atttaaggag gtgtcttatt
      121 gaatatagtt attagtaatt cgagtgggaa gccaatatat gaacagatta ctacacaaat
      181 taaaagtatg attataagtg gagagttacc agaaggctca gctcttccaa gtatgagact
      241 attggcaaaa gaacttagaa taagtgtaat tactacaaaa cgagcatata gcgatttaga
      301 acgagacgga tttattgaga cagttactgg taaaggcagt tttgtatcta gtaaaaacat
      361 ggattttgtc aaagaagaac aatttcgttt aattgaagaa tacctacaaa aagcagttga
      421 tacagcaaaa agtagtgata ttacatatga cgaattaaaa gatattttat ttttattata
      481 taaaggagaa tgataagtat ggatgcaata actataaaaa atttaaataa aacttataaa
      541 gattttagcc tacaagatat atctttttca gtaccaaaag ggagtgtaat gggatttgta
      601 ggtgaaaatg gtgcaggaaa aacaactaca ttaaaagcaa ttttaaattt aatatcttat
      661 gatagtggaa atatagaaat ctttggtctt gatagtaaaa aaaatgaaaa agaaattaaa
      721 gagcaaattg gggttgtatt tgagggaagc aactttcatg aaaatttaaa cactgaccat
      781 gtttcaaaaa tcatgagtaa aatctataaa aattggaatg acacattatt taaagactac
      841 ttaaaaaaat tgagagtacc agacaataaa ttaattaagg agttttcaaa ggggaataag
      901 atgaaactta gtattgctgt agccttatct cataaaccaa aattattaat actagatgag
      961 gcaactagtt cacttgaccc tatcgttcgt gaagaaatac tagatatatt tttagatttt
     1021 atacaagatg aagaacactc tattatctta tcttcacata ttacaagtga tttagataag
     1081 atagcagact atattacatt tatacataaa ggaaaaattg tatttagtga aaataaggat
     1141 gaattaattg atactatggg agttttaaaa tgtaaaccta gtgattttga taacctttca
     1201 agagaggatt attcatatta tcgtaaaagc caatttggat atgaagtact tcttaaagat
     1261 aagcatagat ttatctcaag acatccaaac tgtattgttg ataatacgtc tatagaagaa
     1321 attatgttat tttatgtgag aggtgataaa taatgaaagg tctaatttta aaagatttac
     1381 ttaatttgaa aggaaatata aagtttatac ttttattcat cattatgttt ggctttatgt
     1441 cttctttagg agatggaaat gttaataact ttataggtgt tattatagtt ttatgtacta
     1501 caatgattgt ttcaacattt tcatatgatg atttgaataa atgggatagt tatgtactta
     1561 caatgcctat taatcgcaat gatattgtat taagtaaata tttaactatg ttaatattta
     1621 gctttatagg tgttcttgtt tcacttattg ttagtgtaac tattggttat tttaaaaata
     1681 cacttatatt aaatgaaaca ctacttatta atgcactaat cttatcaatt tcagtatgtt
     1741 ttggtagcct tattctacca cttatttata aatttggtac agaaagagct cgtttattaa
     1801 tgattttatg ctttttagtt ccaacactag ctttattagt ttttaaaagt attttagaaa
     1861 atattagttc acctatttct atagaaatta tacttaatac actagtatat tctcttccat
     1921 ttgttgctat tttactattt gtgatttcat attttatatc atcaaaaatc tatagtaaaa
     1981 aagaagtata aaatatacta tatatgtttc tgtatttaag tatttaaata aaatactatc
     2041 gagtttattt tggtagtatt ttatttttta attattaatc tctactaggt atttattat
//
LOCUS       DAEPID010000180         1989 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.185, whole genome shotgun sequence.
ACCESSION   DAEPID010000180 DAEPID010000000
VERSION     DAEPID010000180.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 1989)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1989)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1989
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.185"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            458..1798
                     /locus_tag="KR257_003796"
     CDS             458..1798
                     /locus_tag="KR257_003796"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888366.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GHKL domain-containing protein"
                     /protein_id="HBH0032444.1"
                     /translation="MIKSSLFWNIFIAISFMIEWFLCKKMLDYTSEKRISNKKINFCV
                     VGIIVFADIIYFFDVPPNIRVIISMIITIAFYKISYDVGFIKSVLISLIYWMLLIATD
                     ALSISLTVWLNSINDMSSMGTGDIYRIESIILGKILLIVSLLLYRALKIKLNIEINKR
                     TLFYIVIPIVANIASFFVIFEYIFNPGSGSLIHNFQFVMISVVLLISSITLVLIAKKL
                     QQYNTLVVENNMIKNTLKYENEYYEDIEKKYLKTRLLSHDMKNHILCINAMIKKGIDV
                     TSYLNNLQVEIQSNDLLFNTGNFILDAILSEKKEVCDKNDIELKIGINFSCCEAVELV
                     DICHIFSNILDNAIEACNKIDSGNRVICVKGDVMQNFYLIRVENTKMNKIITKNGDIL
                     TDKKGSLHGLGIKSVKNSVNKYGGNVVIEYDDKKFVVKIAIPLRNVKKAVNHVI"
BASE COUNT          791 a          144 c          306 g          748 t
ORIGIN      
        1 attttatcta atgattgttt tttataatag ttaaatttcc atttgtagtg tttaaatata
       61 aatctataac agcatttcta taaatgttat aaatcactat aatgattcaa ctcaaagtta
      121 ctgcttaaag aagcagagat tttatcaagg tatatcatgg aaaaaaatat tttattgtaa
      181 tatttataag attttattat ggaaataatg taaaaacttt ataaataata tattttatac
      241 ctagttatag ataaatttat atagttatta ttaaaaaaag caataaaaag tttaattcaa
      301 tttagcaaat ttagtgatat aattaaaaaa gaaaagaaat atggacttat ttggaataat
      361 tttgacaatc tatttactac acgtgtagag tcgtatataa ttaaattata cataaaatat
      421 aaaaaaataa tttagtaata cgttaggaga aagtattatg ataaagtcaa gcttattttg
      481 gaatattttc attgcgatat cctttatgat agaatggttt ctttgtaaga aaatgctaga
      541 ttatacaagt gagaaaagga tttctaacaa aaaaataaac ttttgtgtgg taggtattat
      601 tgtttttgct gacataatat atttttttga tgtacctcca aatataagag taattatatc
      661 tatgataatt actattgcat tttataaaat ctcatatgat gtggggttta taaagtctgt
      721 attaatatcc ttaatttatt ggatgttact aatcgccaca gatgctttga gtatatcttt
      781 aacagtttgg cttaattcta taaatgacat gagtagtatg gggacgggag atatatacag
      841 aattgagtct ataatattgg gaaagatact tttgattgtg tctttgcttt tatatagagc
      901 cttaaagata aaacttaata tagaaataaa taaaaggaca ttattttata tagttattcc
      961 tatagtcgct aatatagcat ctttttttgt aatttttgaa tacatattta atccagggtc
     1021 tggtagctta atacataatt tccaattcgt tatgatttct gttgtattgc ttatatcaag
     1081 tatcacttta gttttaattg ctaaaaaatt acagcaatat aatactttag ttgtagaaaa
     1141 taatatgatt aaaaatactt tgaagtatga aaatgagtat tatgaagata tagaaaagaa
     1201 atatttaaaa actagattac taagtcatga tatgaaaaat cacatcttgt gtataaatgc
     1261 tatgattaaa aaaggtattg atgttacttc ttatttaaat aatttgcagg tagaaattca
     1321 gagtaatgac ttgttattta atactggtaa ttttatatta gatgctatat taagtgaaaa
     1381 gaaagaggtt tgtgataaga atgatataga actaaaaata ggaataaatt ttagttgttg
     1441 tgaagctgtt gaattagtgg atatatgtca tatattttca aatattttag acaatgcaat
     1501 tgaggcatgt aataaaattg atagtggaaa tagagttatt tgtgttaaag gtgatgttat
     1561 gcaaaatttt tatttaataa gagttgaaaa tactaagatg aataagatta ttactaaaaa
     1621 tggagatatt ttgacagaca aaaaaggttc tcttcatgga cttggaataa aaagtgtaaa
     1681 aaactctgta aataagtatg gtggtaatgt tgtaattgaa tatgatgata aaaaatttgt
     1741 agttaaaatt gctattccac ttagaaatgt gaagaaagca gttaatcatg tgatttaaat
     1801 gtatataaat ttgatgtgta gaaatttaat atataagaat taatgtataa aagtgatgca
     1861 tagaagttta atatataaga attaatgtat aaaagtgatg tatagaagtt taatatataa
     1921 gaattaatgt ataaaagtga tgtatagaag tttaatatat aagaatttaa tatgtataaa
     1981 agtgatgca
//
LOCUS       DAEPID010000181         1986 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.186, whole genome shotgun sequence.
ACCESSION   DAEPID010000181 DAEPID010000000
VERSION     DAEPID010000181.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 1986)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1986)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1986
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.186"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            84..200
                     /gene="rrf"
                     /locus_tag="KR257_003797"
     rRNA            84..200
                     /gene="rrf"
                     /locus_tag="KR257_003797"
                     /product="5S ribosomal RNA"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00001"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: cmsearch."
                     /db_xref="RFAM:RF00001"
     gene            207..281
                     /locus_tag="KR257_003798"
     tRNA            207..281
                     /locus_tag="KR257_003798"
                     /product="tRNA-Asn"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:239..241,aa:Asn,seq:gtt)
     gene            286..360
                     /locus_tag="KR257_003799"
     tRNA            286..360
                     /locus_tag="KR257_003799"
                     /product="tRNA-Glu"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:319..321,aa:Glu,seq:ttc)
     gene            366..441
                     /locus_tag="KR257_003800"
     tRNA            366..441
                     /locus_tag="KR257_003800"
                     /product="tRNA-Val"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:399..401,aa:Val,seq:tac)
     gene            447..523
                     /locus_tag="KR257_003801"
     tRNA            447..523
                     /locus_tag="KR257_003801"
                     /product="tRNA-Asp"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:481..483,aa:Asp,seq:gtc)
     gene            534..608
                     /locus_tag="KR257_003802"
     tRNA            534..608
                     /locus_tag="KR257_003802"
                     /product="tRNA-Thr"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:566..568,aa:Thr,seq:tgt)
     gene            623..707
                     /locus_tag="KR257_003803"
     tRNA            623..707
                     /locus_tag="KR257_003803"
                     /product="tRNA-Tyr"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:657..659,aa:Tyr,seq:gta)
     gene            717..790
                     /locus_tag="KR257_003804"
     tRNA            717..790
                     /locus_tag="KR257_003804"
                     /product="tRNA-Gly"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:749..751,aa:Gly,seq:tcc)
     gene            801..877
                     /locus_tag="KR257_003805"
     tRNA            801..877
                     /locus_tag="KR257_003805"
                     /product="tRNA-Arg"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:835..837,aa:Arg,seq:tct)
     gene            887..962
                     /locus_tag="KR257_003806"
     tRNA            887..962
                     /locus_tag="KR257_003806"
                     /product="tRNA-Gln"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:920..922,aa:Gln,seq:ttg)
     gene            974..1049
                     /locus_tag="KR257_003807"
     tRNA            974..1049
                     /locus_tag="KR257_003807"
                     /product="tRNA-Lys"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:1007..1009,aa:Lys,seq:ttt)
     gene            1052..1140
                     /locus_tag="KR257_003808"
     tRNA            1052..1140
                     /locus_tag="KR257_003808"
                     /product="tRNA-Ser"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:1086..1088,aa:Ser,seq:tga)
     gene            1158..1248
                     /locus_tag="KR257_003809"
     tRNA            1158..1248
                     /locus_tag="KR257_003809"
                     /product="tRNA-Ser"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:1192..1194,aa:Ser,seq:gct)
     gene            1257..1333
                     /locus_tag="KR257_003810"
     tRNA            1257..1333
                     /locus_tag="KR257_003810"
                     /product="tRNA-Pro"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:1291..1293,aa:Pro,seq:tgg)
     gene            1419..1494
                     /locus_tag="KR257_003811"
     tRNA            1419..1494
                     /locus_tag="KR257_003811"
                     /product="tRNA-Trp"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:1452..1454,aa:Trp,seq:cca)
     gene            1555..1631
                     /locus_tag="KR257_003812"
     tRNA            1555..1631
                     /locus_tag="KR257_003812"
                     /product="tRNA-Pro"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:1589..1591,aa:Pro,seq:tgg)
     gene            1638..1714
                     /locus_tag="KR257_003813"
     tRNA            1638..1714
                     /locus_tag="KR257_003813"
                     /product="tRNA-Ile"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:1672..1674,aa:Ile,seq:gat)
     gene            1718..1793
                     /locus_tag="KR257_003814"
     tRNA            1718..1793
                     /locus_tag="KR257_003814"
                     /product="tRNA-Phe"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:1751..1753,aa:Phe,seq:gaa)
     gene            1801..1877
                     /locus_tag="KR257_003815"
     tRNA            1801..1877
                     /locus_tag="KR257_003815"
                     /product="tRNA-Met"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:1835..1837,aa:Met,seq:cat)
BASE COUNT          517 a          452 c          531 g          486 t
ORIGIN      
        1 taactctaaa aaaaaataaa aaaagtattg acaaaaatag taaaaaatgt taatattata
       61 cttgtcctag caacaagaaa aaatgtggtt ataatagcgg aggagataca cctgtttcca
      121 ttccgaacac agaagttaag ttctctagcg ctgatggtac ttggtgggaa actgcctggg
      181 agagtaggac atagccacgt gaatgttcca aggtagctca acggtggagc aaccggctgt
      241 taaccggtag gctgtgggtt cgagccccac ccttggagcc attatggctc gttggtcaag
      301 aggttaagac accgcccttt cacggcggta acaggggttc aattccccta cgagtcacca
      361 tttgtgggat catagctcag ctgggagagc acctgcctta caagcagggg gtcacaggtt
      421 cgagccctgt tggtcccacc atttgcggcc tggtagttca gttggttaga atgccagcct
      481 gtcacgctgg aggtcgaggg ttcgagcccc ttccaggtcg ccaaaataaa aatgctggtg
      541 tggctcaacg gtagagcagc tgacttgtaa tcagcaggtt gtaggttcga ttcctatcac
      601 cagctccatg taaaactaat acggaggatt tcccgagcgg ccaaaggggg cagactgtaa
      661 atctgttgtc atcgacttcg gtggttcgaa tccaccatcc tccaccaatt aaatatgcgg
      721 gtgtagctca atggtagagt tctggccttc caagccagct gtgagggttc gatccccttc
      781 acccgctcca aagaaagcgt gggtgcatag ctcagctgga tagagcaacg cccttctaag
      841 gcgtgtgtcc ggggttcgaa tccctgtgcg ctcaccacat atatattggg gattagccaa
      901 gtcggtaagg cacatgactt tgactcatgt atgcgtaggt tcgagtcctg catccccagc
      961 caaataaaaa tatggtctat tagctcagtc ggtagagcac ctgactttta atcagggtgt
     1021 cccgcgttcg agtcgcggat agatcaccaa tggagaggtg tccgagtggt ttaaggagct
     1081 ggtcttgaaa accagtgact tcgaaagggg ccgtgggttc gaatcccacc ctctccgcca
     1141 aaaaaatgac tgaatttgga gaagtactca agtggctcaa gaggatcccc tgctaaggga
     1201 ttaggctggg taaccggtgc gagggttcga atccctcctt ctccgccatt caaaaacgag
     1261 gtgtagcgca gtttggtagc gcacatggtt tgggaccatg gggccggggg ttcgagtccc
     1321 ttcacctcga ccaacttaag cttttagttc agttggttag agtgcccaac tcatggctag
     1381 taattctagg gtttgagtcc atgaaggtta ttcttcatag gggtgtagct cagttggtag
     1441 agcgtcggtc tccaaaaccg tgcgccgggg gttcgagtcc ctccacccct gccaaataaa
     1501 aaggacttga aaaaagttgg attttagagt agtataagat agtaaataag atttcgaggt
     1561 gtagcgcagt ttggtagcgc acatggtttg ggaccatggg gccgggggtt cgagtccctt
     1621 cacctcgacc aagaaaaggg cctatagctc aggtggttag agcgcacgcc tgataagcgt
     1681 gaggtcgctg gttcgagtcc agctaggccc accatttgcc cagatagctc agtcggtaga
     1741 gcaggggact gaaaatcccc gtgtcggtgg ttcgattccg cctctgggca ccaggaatac
     1801 ggcggtatag cttagttggc tagagcgttc ggttcatacc cgaaaggtca taggttcgac
     1861 tcctattacc gctaccatct aactatatca ataaagaact ttgaaaatta aacagtaggt
     1921 taatttataa acaagaaaca aaccataaag ccagatattt tgataacaat agtatctgag
     1981 cctgat
//
LOCUS       DAEPID010000182         1983 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.187, whole genome shotgun sequence.
ACCESSION   DAEPID010000182 DAEPID010000000
VERSION     DAEPID010000182.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 1983)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1983)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1983
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.187"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     repeat_region   16..1155
                     /inference="COORDINATES: alignment:crt:1.2"
                     /inference="COORDINATES: alignment:pilercr:v1.02"
                     /rpt_family="CRISPR"
                     /rpt_type=direct
                     /rpt_unit_range=16..44
                     /rpt_unit_seq="gttttatattaactaagtggtatgtaaat"
     gene            1216..1644
                     /locus_tag="KR257_003816"
     CDS             1216..1644
                     /locus_tag="KR257_003816"
                     /EC_number="2.3.1.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903360.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="N-acetyltransferase"
                     /protein_id="HBH0032445.1"
                     /translation="MIKKLNNKDINKIMEIWEKSTIKAHDFISKEYWQNNYNTVKNEY
                     IPISDTFVYDDGDEIKGFISIIDKSFIGALFIKPKYQNLGIGGKLLDYATKKYKSLSL
                     AVYKDNKKAVVFYNKKGFNIVKEQVNEDSGFKEYIMEYSK"
BASE COUNT          781 a          185 c          275 g          742 t
ORIGIN      
        1 atttttctcg taatagtttt atattaacta agtggtatgt aaataccatt catttatatt
       61 tttatctgta tctcttagcc atgttttata ttaactaagt ggtatgtaaa ttaagttttc
      121 ttaaaaaagt acttgcttta aatatgtttt atattaacta agtggtatgt aaattttatt
      181 ttctctttat tagtcattag tttttgcctt cgttttatat taactaagtg gtatgtaaat
      241 atgaagaatt tgcgaaacta ataagaaaag atattgagtt ttatattaac taagtggtat
      301 gtaaatcttt ctttatcaaa gtaagctaaa tttagttcct ccgttttata ttaactaagt
      361 ggtatgtaaa tcgtcattac tttttattgc ttccattaaa tttgttcgtt ttatattaac
      421 taagtggtat gtaaatatcg caagataggc taaatctatc aaggagagtt gagttttata
      481 ttaactaagt ggtatgtaaa tgactctgcc atccctgtaa caaacagtct taccgcaagt
      541 tttatattaa ctaagtggta tgtaaataaa tattttacga ttagttgatg ctataattct
      601 attagtttta tattaactaa gtggtatgta aattcgggct agaatgtatt ttaaacccta
      661 gttcattgaa gttttatatt aactaagtgg tatgtaaatt ttctaatatc gctatttaaa
      721 ctcaatgctt catttgtttt atattaacta agtggtatgt aaattcagaa caaattaaat
      781 atgtttcgtt ttccatgtaa ggttttatat taactaagtg gtatgtaaat agaacttttt
      841 tatattagaa gtacttgaca tgattgccgt tttatattaa ctaagtggta tgtaaatctt
      901 gataatattt cagcatatga tactgaagat ggttttatat taactaagtg gtatgtaaat
      961 ttgccaatgt aacatcttta gatattacag tatcattgtt ttatattaac taagtggtag
     1021 ataagtagaa tattagcaat atcaacgagt atttagaaac ttattttata ttaataaagc
     1081 agtatataaa attgtagaat caacaatagc atatactaaa acatccacct tatattaact
     1141 aaatcatatc taaataaaat aaacttacct ataaacatta taaaatcaat acaaaaatga
     1201 ggtgaaataa aatttatgat aaagaaatta aacaataaag atataaataa aatcatggaa
     1261 atatgggaaa aaagtacaat caaagcacat gactttataa gtaaagaata ctggcaaaat
     1321 aactataata ctgttaaaaa cgaatatata cctatatcag atacatttgt atatgatgat
     1381 ggagatgaaa taaaaggatt tataagcata atagataaaa gctttatagg agctttattt
     1441 ataaagccca aataccaaaa tctaggtatc ggaggtaaac ttttagatta tgcaactaaa
     1501 aaatataaaa gtctaagctt agcagtatat aaagataata aaaaagcagt tgtgttttat
     1561 aataaaaaag gttttaatat agtaaaagaa caagtaaatg aagattcagg atttaaagag
     1621 tacataatgg aatatagtaa ataatatgat tacattctat taaaaggata attaatttat
     1681 ttgccatttg attttttaag agtaattttt aaaatagact atatgaagat aaagatattt
     1741 attatagatg taagttaatc agaattgata tagctacaaa agaggaaaat aaaattgtat
     1801 ggtgtatttc agatttaaca aatttactat ttaaagataa taagtttgat ataatattaa
     1861 agatactttc acctataaac tatagggtat ttgaaagaat tttaaataat tatggaatgc
     1921 taataaaggt ttgttaaaat ttaataatta ttagattata gaaaattgcc atgaaattag
     1981 ttc
//
LOCUS       DAEPID010000183         1918 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.189, whole genome shotgun sequence.
ACCESSION   DAEPID010000183 DAEPID010000000
VERSION     DAEPID010000183.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 1918)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1918)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1918
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.189"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            347..1675
                     /locus_tag="KR257_003817"
     CDS             347..1675
                     /locus_tag="KR257_003817"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896511.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amino acid permease"
                     /protein_id="HBH0032446.1"
                     /translation="MGSNELKKTLGVSAALSTVVGSVIGAGVFFKPQAVYTLTGGAPG
                     LGILAWLIAGIITITAGLTAAEVSVAIPKTGGMMVYIKEIYGEKLGFLTGWMQIVLFY
                     PGMMAALGVIFGEQASALIGSPSLLLPIAIGIIVIVAGLNMLGSKTGGVIQTVSTICK
                     LIPLILIMVVGFIKGGGNNPILTPMVGEGLSLGSVLGQVLIAILFAFDGWMNVGTLAG
                     EMKNPGKDLPKAIIGGLSVVMAVYFIINLAYLWVLPANELANYASPASAVAEVIFGSM
                     GGKIISVGILISVFGALNGFLLTGSRVAYTLATDKTLPKYGIFSKLNSAQVPANAIAL
                     VSVIASIYALSGQFNLLTDLAVFATWIFYVLTFIGVMKLRKTHPNIPREYKVPLYPIV
                     PIIAIASGIFVVVNQLCFAGMKTTMISIGGLVITAIGLPVYAYMTRGVKR"
BASE COUNT          669 a          214 c          338 g          697 t
ORIGIN      
        1 aactacagaa agaagccaaa atgtttttga aaaaaatgaa attttattgc aaaaaaatca
       61 aaatgaattt aacttaatag ttataatcta tttttagtgt tacaaatata caatgtatat
      121 tatacaatat aaaaaataca tttacttaga agtattatta tatttggatt tttggttttt
      181 ataatttttt tatatttaaa catagctaaa aataaaagat tacgaaagct aagtagagtt
      241 tattttattt taataaataa taaagctatt tttctatata ttggcataat atatgcttat
      301 ttaactatga aattaaaatt aaataggatt aatgaggagg aaaaaaatgg gaagtaatga
      361 actgaaaaag actcttggcg tatcagcagc attatcaact gttgttggtt ccgttatagg
      421 agcgggcgta ttttttaaac cacaagcagt ctatacatta actggaggag ctccaggtct
      481 tggtatattg gcatggttaa tagctggaat cataactata acagctggtc ttacagctgc
      541 agaggtatca gttgcgatac caaaaactgg tggaatgatg gtatatataa aagaaattta
      601 tggagaaaaa ttaggttttt taactggatg gatgcaaatt gtattatttt atccagggat
      661 gatggcagca ttaggtgtta tatttggaga acaagcatca gcactaattg gtagtccatc
      721 acttttactt ccaatagcaa ttggaattat agtaatagtt gcagggctta atatgttagg
      781 ttcaaaaact ggaggagtca tacaaactgt ttctacaatt tgtaagttaa taccacttat
      841 tttaataatg gttgttggat ttattaaagg tggtggaaat aatccaatac ttacacctat
      901 ggttggtgaa ggattaagcc tgggtagtgt actaggtcaa gttttaattg ctatattatt
      961 tgcttttgat ggatggatga atgttggtac tttagctgga gaaatgaaga atcctggaaa
     1021 agaccttcca aaagctataa taggtggatt gtcagttgtt atggctgttt attttataat
     1081 aaatttagcg tatctttggg tattaccagc taatgaatta gcaaattatg cttctcctgc
     1141 atcagcagtt gctgaagtta tatttggttc aatgggtgga aaaataatat ctgtaggtat
     1201 attaatttca gtgtttggag cattaaatgg atttttacta actggttcaa gggtggcata
     1261 tactttagct acagataaga ctttaccaaa gtatggtata ttttctaaat taaattctgc
     1321 tcaagttcca gcaaatgcaa tagcattagt atctgttatt gcatctatat atgctttgtc
     1381 aggtcaattt aatttattaa ctgacttagc tgtatttgct acttggatat tctatgtatt
     1441 aacttttata ggggttatga aacttagaaa gactcatcca aatataccaa gagagtataa
     1501 agttccatta tatcctattg ttcctataat agctatagca agtggtatat ttgttgtagt
     1561 taatcaattg tgttttgcag gtatgaaaac tactatgata tctataggag gtcttgtaat
     1621 aacagctata ggcttaccag tgtatgctta tatgactaga ggagtaaaaa gataaaccaa
     1681 gtagtttaca aatgcttcat aattaaaata aaagagactg tctcaaatag agataagtct
     1741 cttttttatt gttaaaatgg taaagatatg tttaatttta caaaaaaaga gcgttccatg
     1801 aactaaaaag tttattttaa ggtattcatt ttatttttag ttttttgatt ataaaattaa
     1861 acatctaaaa aattatttat tttaaaatac tttattttaa agtgtttttt atcaaact
//
LOCUS       DAEPID010000184         1845 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.190, whole genome shotgun sequence.
ACCESSION   DAEPID010000184 DAEPID010000000
VERSION     DAEPID010000184.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 1845)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1845)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1845
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.190"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            17..415
                     /locus_tag="KR257_003818"
     CDS             17..415
                     /locus_tag="KR257_003818"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861413.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0032447.1"
                     /translation="MNKKKKLIGIAISFLLIISIINPLQVEAEAIIESSVYISSIKEN
                     YTYDNTKFKTIKSKSRHKSRKYNKSKVKLKKRSIRTKKYGYQTINKYKRQNARRHNIL
                     TKLILFIIVIFLVIVLVVLIFIKRKKKKFY"
     misc_binding    850..1113
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00230"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="T-box leader; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /bound_moiety="tRNA"
                     /db_xref="RFAM:RF00230"
     gene            1264..1815
                     /locus_tag="KR257_003819"
     CDS             1264..1815
                     /locus_tag="KR257_003819"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424155.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tryptophan transporter"
                     /protein_id="HBH0032448.1"
                     /translation="MKTNTKKLTLNAILLAMGLLIHQITPAIGLPMKPDVPLAMLFVI
                     LVLNRDDYKTCLIAGIVTGIFTALTSSFPGGQIPNVIDKTLTANIVFLLMNISYNMPF
                     IKKLAKKTQDTVVVAIIMPIGTLVSGTIFLLAAQAIVGLPGASFTALFLAVVLPAVLI
                     NLVAGIFLFKIVSLSIRRVSYQA"
BASE COUNT          776 a          178 c          285 g          606 t
ORIGIN      
        1 ttatgagggg gaaaatatga ataagaagaa aaaattgatt gggatagcta tatcttttct
       61 acttataatc agcattataa atccattaca agtagaagca gaagctatta ttgagtctag
      121 tgtatacatt tcttcaataa aagagaatta tacatatgat aatactaaat ttaaaactat
      181 taaatctaaa agtagacata aaagtaggaa atataataaa agtaaagtaa agttgaaaaa
      241 acgaagtata agaactaaaa agtatggata tcaaactata aataaatata aaagacaaaa
      301 cgcaagaaga cataatatcc taacaaaatt aatattgttc ataatagtca tatttttggt
      361 tatagtttta gtagtgctaa tatttattaa aagaaagaag aaaaaatttt actaaaaata
      421 attaaaagaa tatcattttt ttaatcattg gtatctattt aataatatga tgtaattaaa
      481 atggagtaat attctgtttc aaaggaggca tataaataca ggaatgagta ttaaatgatg
      541 gttaattaag taaatttatt gataaatgta cttaattaac tttgaagaat ttaattcctc
      601 atgaatcaaa atataaaatt acatcaacag ttattcacaa aattaatata agaagaatta
      661 gagccaaaga gcagactatt agaccattaa agtaattatt catagaattt tgtatatgaa
      721 aagaaatgta tagtataatt tacttttttt ataaaaaata gattacaaaa tatatttttt
      781 ataaaaaggt attgacattt tttagaaaaa agaatattat tattttaaaa caaaattcaa
      841 tacaataaat taaatcctat gacaaggaag agtagttaaa tttaggttca gtatagagag
      901 ctgaggatgg tggaatctta gcaagaaaaa atttgatgaa tggcccttag aggaataaat
      961 tgaaatcata gttttgagag tagactttat cgtcagtcgc acgttatagc gaataaggta
     1021 tgtaagtacc tgataatgag atgtatgaaa attgaatttt atattaattt ttatataatt
     1081 taggtggcaa cgcggataat ctccgtccta ttagtttagg acggagtttt ttattttact
     1141 gaaaatttaa aagatagaag gtggtgagaa agatgttatg aatttcaaaa gctaaagatg
     1201 atgatatagt aggttggcaa aaaaataaat tgaaaattaa aaaaatagga ggaagtacaa
     1261 aaaatgaaaa caaatacaaa aaaattaact ttaaatgcaa tacttttagc gatgggatta
     1321 ttaatacatc aaatcacacc agctatagga ttaccaatga agccagatgt accactagca
     1381 atgttatttg taatattggt tttaaataga gatgattata aaacttgttt gatagcgggt
     1441 atagtaacag gaatatttac agcacttaca tcaagttttc cgggaggtca aattcctaat
     1501 gtaatagata aaactcttac agcaaatata gtatttttat taatgaatat tagttataat
     1561 atgcctttta taaaaaaatt agctaagaaa acacaagata ctgtagtagt tgcaataata
     1621 atgccaatag gaactcttgt aagtggaact atctttttat tagcagctca agctatagtt
     1681 ggtcttccag gggcttcatt tacagcttta ttcttagcag tagtattacc agctgtttta
     1741 ataaatctag ttgcaggaat atttttattc aagattgtta gtctatcaat aagaagagtt
     1801 agttatcaag cttaaacacg aaataatatt ttactttata aagca
//
LOCUS       DAEPID010000185         1798 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.191, whole genome shotgun sequence.
ACCESSION   DAEPID010000185 DAEPID010000000
VERSION     DAEPID010000185.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 1798)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1798)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1798
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.191"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            <1..535
                     /locus_tag="KR257_003820"
     CDS             <1..535
                     /locus_tag="KR257_003820"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016056345.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=2
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0032449.1"
                     /translation="LLSFNEKKIEKHKCKNYHNDSSKDKYKYSQSEFIAATLKEADDM
                     NEEERRILEAEKRILETEKRVHQDNKEVKESIDKQFNDIKGIFKEYKNDLDKDRIELK
                     NDLARERAELKSDLKEAINEHKKVTEKDVSEIKNSMKGIEDRIDSTNKWIIGLCITTI
                     IGIATMAITIGISIWPK"
     gene            complement(945..1133)
                     /locus_tag="KR257_003821"
     CDS             complement(945..1133)
                     /locus_tag="KR257_003821"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898401.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0032450.1"
                     /translation="MTKTILCDYCNKGINKDDNKYITFHKKSHMKTNICINCALNLID
                     KDKLNENIINNQHDYSKK"
     gene            1391..1534
                     /locus_tag="KR257_003822"
     CDS             1391..1534
                     /locus_tag="KR257_003822"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861731.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0032451.1"
                     /translation="MSEFLLGVLASLTASFITYIISRKVKSHSGRSDFELDVKIKFNK
                     KRH"
BASE COUNT          757 a          191 c          236 g          614 t
ORIGIN      
        1 tttattgagt tttaatgaaa aaaagataga aaaacataaa tgtaaaaatt atcataatga
       61 ttcttcgaaa gataaataca aatatagtca aagtgaattt atagctgcta ctttaaagga
      121 ggcagatgat atgaatgaag aagaaagaag aatactagaa gcagaaaaaa gaatattaga
      181 gactgagaaa agagtgcatc aagataacaa ggaagtaaaa gaaagtatag ataagcaatt
      241 taatgacata aagggtattt ttaaagaata caagaatgat ttagacaaag atagaataga
      301 actaaaaaat gatttagcta gagaaagagc tgagttaaaa agtgatttaa aagaagctat
      361 aaacgaacat aaaaaggtca cagaaaagga tgtaagtgaa ataaagaata gtatgaaagg
      421 tatagaagat agaattgatt caactaataa atggattatt ggactatgta taactactat
      481 aataggaatt gctacaatgg ctattacaat aggtatatct atatggccaa agtaacacaa
      541 aaagaggtaa ctagaattaa aatagttatc tctttttata cttaaacaaa acattgaaaa
      601 aatagtaaaa aatattaaca ggatacataa aactatagta taacctgtaa taataaaacg
      661 aacgaaaatt atcatactaa aacataagac atgctataat tgtattagat aaatgcttga
      721 atatatacca aaagtactct ttttataaga gtgcttattt ttttgaaatt catcaacata
      781 taaacaatca agaacattac tcaacacacc ttaaaattga tttaaattct ttttcataca
      841 caaagttata tgatataata aaaaagtaaa tatgtaaccc caacacatct ttactaagtc
      901 aaacattatt atatagagca ttcttcatta tggagagtgc tttttcattt ctttgaataa
      961 tcatgttgat tatttataat attttcattt aatttatctt tatctatcaa atttaatgca
     1021 caattaatac aaatgttagt tttcatatga cttttcttat gaaaagtaat atacttatta
     1081 tcatctttat ttattccttt attacagtaa tcacataata tagtcttagt catattttta
     1141 ttcctttcat tttatatttt ccataattaa gtttaacata tttagtatat acctatgtat
     1201 atatatttaa aacaatgttt tttattgcaa tatagaatat attgtataaa taaaaaaaat
     1261 ggagaataga tatttgataa ttgtaaaatt atgttataat taaaatgcaa gaataatctt
     1321 gtggaactac aatctaagag tggagcttca ttttctacat tccatccctt aaaaggaagg
     1381 aggtggagaa atgagcgaat ttttactagg agtgttagct agtttaacag ctagctttat
     1441 tacatatatt atttccagaa aagtaaaaag ccactctggc aggagtgact ttgagcttga
     1501 tgtaaaaatc aagtttaata aaaaacgaca ttaatattta gttaatgaaa cttcactcta
     1561 ggctaataga ttgtagtttc tttttttgtt tttgatacga atttacatct ttattatatc
     1621 gcattttgag aaaaaataaa actatgaata ttagaaatat attttatttt atctctaagt
     1681 atatatatta ttagccacct aaaaaacttt cacaaaaaca aaaagagtat atgtttttga
     1741 taactggatg atataactta taactcattt tacaattctt agttcatata tatttatg
//
LOCUS       DAEPID010000186         1553 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.192, whole genome shotgun sequence.
ACCESSION   DAEPID010000186 DAEPID010000000
VERSION     DAEPID010000186.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 1553)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1553)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1553
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.192"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            <1..518
                     /locus_tag="KR257_003823"
     CDS             <1..518
                     /locus_tag="KR257_003823"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861009.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=3
                     /transl_table=11
                     /product="DNA cytosine methyltransferase"
                     /protein_id="HBH0032452.1"
                     /translation="KNLEQLNNPTHSTNRIYDAVGIARCIRSQAGGGGAKTGLYFIDL
                     NKNSKVTINARCLKAKYNAGVTNRNCDNSGVLVNAVLTPDRVNKRQNGRRIKESGETM
                     FTLTAQDKHGILKNGDIRRLTPKECFRLQGFPDKYYERAASVCSDSQLYKQAGNAVTA
                     NVVYEIAKRMG"
     gene            598..807
                     /locus_tag="KR257_003824"
     CDS             598..807
                     /locus_tag="KR257_003824"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861010.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0032453.1"
                     /translation="MYEYILRWQIGLSLENRKIHYTYGSKEALRKKAKALAKDENIVL
                     ITIDKVDEVIKNTISEKIIERFENL"
     gene            819..>1553
                     /locus_tag="KR257_003825"
     CDS             819..>1553
                     /locus_tag="KR257_003825"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729497.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nucleoid-associated protein"
                     /protein_id="HBH0032454.1"
                     /translation="MIIHKFIIHVLDKNSDTPILNDFEGRVNQDMVLFFQKKISKVSR
                     DNDIRTAVFNNYSNNLIKKCCEQIIYDESSFLNNSKEIAAYLFDVMKLNATLESCDLA
                     ICLYSQKDEKKVAILKLDYNNSYTHSIEFKDDKFNIQMSKNEINIQETKTVKIAALVG
                     LSGMNDKYHLRVLDKDAEKEEANSKFVTEFLNATKIKDDKYKTKKFKNTAENWITNAL
                     SNDIKQAEDVRSILNYTLREKHEIDIN"
BASE COUNT          651 a          152 c          300 g          450 t
ORIGIN      
        1 gaaaaaatct tgagcaacta aataatccaa ctcatagtac aaatagaatt tatgatgcag
       61 ttggaattgc tagatgtatt agaagtcagg caggaggtgg aggtgctaaa acaggtctat
      121 actttataga cttaaataaa aactctaaag taacaataaa tgctagatgc cttaaagcaa
      181 aatataatgc aggtgtgaca aatagaaatt gtgataatag tggagtttta gttaatgcag
      241 ttttaacgcc cgatagggta aataaaagac aaaatggtcg tagaattaaa gaaagcggag
      301 aaacaatgtt cacattgaca gctcaagata aacatggaat tttgaaaaat ggagatataa
      361 gaaggttaac accaaaggaa tgctttaggt tgcaaggatt tccggataaa tattacgaaa
      421 gagcagcaag tgtatgctca gatagtcaac tgtacaagca agcaggaaat gctgttactg
      481 caaatgttgt atatgaaata gcaaaaagaa tgggctaaaa gttgcaaaat gtcttttagt
      541 atgaatattt ttgaagtgtt ttgtaactct caaaaatgaa aataaggggt gggataaatg
      601 tatgaatata tattaagatg gcaaatagga ttatcgttag aaaatagaaa aatacattat
      661 acatatggaa gtaaagaagc tttaagaaag aaagcaaagg cattggctaa agatgaaaat
      721 atagtactaa taactataga taaggtagat gaagttataa aaaatactat aagcgagaag
      781 attatagaac gttttgaaaa tttataaggg gtggaattat gataatacac aaatttataa
      841 tacatgtttt agataagaat agtgatacac caatattgaa tgattttgaa ggtagggtta
      901 atcaagatat ggtcctattt tttcaaaaga aaataagcaa agtatcaaga gataatgaca
      961 tcagaacagc agtatttaat aactatagta acaatctaat taagaagtgt tgtgaacaaa
     1021 ttatttatga tgaaagttca tttttaaata actctaaaga gattgcagct tatttatttg
     1081 atgttatgaa attgaatgct acattagaat cttgcgactt agcaatttgt ttatactctc
     1141 aaaaagatga aaagaaagtt gctatattaa agcttgatta caataattcg tatactcatt
     1201 caattgagtt taaagatgat aaatttaata tacagatgtc taaaaatgaa attaatatac
     1261 aagagactaa gacggttaaa attgctgctt tggttggatt gagtggaatg aatgacaaat
     1321 atcatcttag ggttttagac aaggatgcag agaaggaaga agctaattct aagtttgtta
     1381 cagagttctt aaatgccact aagataaaag atgataagta taagactaag aagttcaaaa
     1441 atacagctga gaattggata actaatgctc ttagtaatga tataaaacaa gcagaggatg
     1501 taagaagtat attaaattat actttgagag aaaagcatga aattgatata aat
//
LOCUS       DAEPID010000187         1549 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.193, whole genome shotgun sequence.
ACCESSION   DAEPID010000187 DAEPID010000000
VERSION     DAEPID010000187.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 1549)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1549)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1549
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.193"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            complement(<1..735)
                     /locus_tag="KR257_003826"
     CDS             complement(<1..735)
                     /locus_tag="KR257_003826"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729497.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nucleoid-associated protein"
                     /protein_id="HBH0032455.1"
                     /translation="MIIHKFIIHVLDKNSDTPILNDFEGRVSQDMDLFFQKKIKTVSR
                     AKDIRTAVFNDYSNNLIKKCCEQIIYDESSFLNNSKEIAAYLFDVMKLNATLESCDLA
                     ICLYSQKDEKKVAILKLDYNKSYTHSIEFKDDKFNIQMSKNEINIQETKTVKIAALVG
                     LSGMNDEYHLRVLDKDAEKEEANSKFITEFLNATKVKDDKYKTKMFKSTAENWITNAL
                     GNDIKQAEDVRSILNYTLKEKHEIDIN"
     gene            complement(732..953)
                     /locus_tag="KR257_003827"
     CDS             complement(732..953)
                     /locus_tag="KR257_003827"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018112749.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0032456.1"
                     /translation="MSKYVLRWQKGLLLDERKINYSCGSKEMLKQKAELLAKDDKILL
                     VTIDKVEEVIKDTRSQKMTEYYCDGGIEI"
     gene            complement(1032..>1549)
                     /locus_tag="KR257_003828"
     CDS             complement(1032..>1549)
                     /locus_tag="KR257_003828"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861009.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=3
                     /transl_table=11
                     /product="DNA cytosine methyltransferase"
                     /protein_id="HBH0032457.1"
                     /translation="KNLEQLNNPTHSTNRIYDAVGIARCIRSQAGGGGAKTGLYFIDL
                     NKNSKVTINARCLKAKYNAGVTNRNCDNSGVLVNAVLTPDRVNKRQNGRRIKESGEPM
                     FTLTAQDKHGILKNGDIRRLTPKECFRLQGFPDKYYERAASVCSDSQLYKQAGNAVTA
                     NVVYEIAKRMG"
BASE COUNT          443 a          307 c          161 g          638 t
ORIGIN      
        1 atttatatca atttcatgct tttctttcaa agtataattt aatatacttc ttacatcttc
       61 tgcctgtttt atatcatttc caagagcatt agttatccaa ttttcggctg tacttttaaa
      121 catcttagtc ttgtacttgt catctttcac tttagtagca tttagaaact ctgtaataaa
      181 cttagaatta gcttcttcct tttctgcatc cttgtctaaa accctaagat gatattcgtc
      241 attcattcca ctcaaaccaa ccaaagcagc aatttttact gtcttagtct cttgtatatt
      301 aatttcattt ttagacattt gtatattaaa tttatcatct ttaaactcga ttgaatgagt
      361 atatgacttg ttgtaatcaa gctttaatat agcaactttc ttttcatctt tttgagagta
      421 taaacaaatt gctaagtcgc aagattctaa tgtagcattc aatttcataa catcaaataa
      481 ataagctgca atctctttag agttatttaa aaatgaactt tcatcataaa taatttgttc
      541 gcaacacttc ttaattaaat tgttactata gtcattaaat actgctgttc taatgtcttt
      601 agctcttgat actgtcttaa tcttcttctg aaaaaataga tccatatctt gactaaccct
      661 accctcaaag tcatttagta ttggtgtatc gctattctta tctaaaacat gtattataaa
      721 tttgtgtatt atcatatttc aattcctcca tcacaataat attcagtcat tttttgactt
      781 ctagtatcct ttataacttc ttcaacttta tctattgtta caagcagtat cttgtcatct
      841 ttagctaata attctgcttt ttgttttaac atttccttac ttccacaaga ataatttatc
      901 ttacgttcat ccaacaataa ccctttttgc catctaagca catactttga catttattca
      961 ccccttattt tcatttttga gagttacaaa acacttcaac aatactcata ctaaaagaca
     1021 ttttgcaact cttagcccat tctttttgct atttcatata caacatttgc agtaacagca
     1081 tttcccgctt gtttgtacag ttgactatct gagcatacac ttgctgctct ttcgtaatat
     1141 ttatccggaa atccttgcaa cctaaagcat tcctttggtg ttaaccttct tatatctcca
     1201 tttttcaaaa ttccatgttt atcttgagct gttagtgtga acattggttc tccgctttct
     1261 ttaattctac gaccattttg tcttttattt accctatcgg gcgttaaaac tgcattaact
     1321 aaaactccac tattatcaca atttctattt gtcacacctg cattatattt tgctttaagg
     1381 catctagcat ttattgttac tttagagttt ttatttaagt ctataaagta tagacctgtt
     1441 ttagcacctc cacctcctgc ctgacttcta atacatctag caattccaac tgcatcataa
     1501 attctatttg tactatgagt tggattattt agttgctcaa gattttttc
//
LOCUS       DAEPID010000188         1526 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.194, whole genome shotgun sequence.
ACCESSION   DAEPID010000188 DAEPID010000000
VERSION     DAEPID010000188.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 1526)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1526)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1526
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.194"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     repeat_region   20..1169
                     /inference="COORDINATES: alignment:crt:1.2"
                     /inference="COORDINATES: alignment:pilercr:v1.02"
                     /rpt_family="CRISPR"
                     /rpt_type=direct
                     /rpt_unit_range=86..114
                     /rpt_unit_seq="atttacataccacatagttaatataaaac"
BASE COUNT          620 a          240 c          150 g          516 t
ORIGIN      
        1 ttacctatac ttgttgcaaa tttacatacc acgtagttaa tataaaacaa gatgttttta
       61 aaaataaact taatatagat attgaattta cataccacat agttaatata aaactttaat
      121 catatatcag ataggtcaca acttaagagt gatttacata ccacatagtt aatataaaac
      181 aacttctcat attccagata attgttattt tacgaaattt acataccaca tagttaatat
      241 aaaacctgta gatttgcctg tttcgatatt gctcatgtgt gaatttacat accacatagt
      301 taatataaaa ctctcttgtt tcttctgtta attttattat accttcatta tttacatacc
      361 acatagttaa tataaaacgc gttatattgt tgtataaaac cgattaaagt tcaatttaca
      421 taccacatag ttaatataaa acttgcaaca tattgtttta tcgttgctgg gtctttaaaa
      481 ccatttacat accacatagt taatataaaa ctaagcgata ttagagagcg caaggcatag
      541 cggagcaaat ttacatacca catagttaat ataaaacttt aattttaacc accccctttc
      601 actaataaaa aaagatttac ataccacata gttaatataa aacaagacgc tatacaagag
      661 gtaatttgaa agcaatctaa tttacatacc acatagttaa tataaaacgt tgcatatgta
      721 tgtctaagag catgaaattt aattttattt acataccaca tagttaatat aaaacttcta
      781 ttaagtgtaa gcaaaacgct tggaatatga aatttacata ccacatagtt aatataaaac
      841 ttatacacaa atacaacttg aagaagcgct aaagagattt acataccaca tagttaatat
      901 aaaacctaat gagtacatag ataaacgtac aggagaggtt aatttacata ccacatagtt
      961 aatataaaac gttgataatt ttcgtttgta tactttttat aatttaaaat ttacatacca
     1021 catagttaat ataaaacata aagatttaga aaaagaaaaa gttaaaattt tggaatttac
     1081 ataccacata gttaatataa aacttttcct gttaagttga tgtttgcaac tttaactgct
     1141 atttacatac cacatagtta atataaaacc ccaaaataaa ctaagtattt tcagtactta
     1201 cacacataca actctctcaa atttgcagtg aaccatgagt agtgcaattg ataacattta
     1261 tcacacaccc tcaatccctt acattgcaac tgttaaaccc tactttatca aaaatatcgc
     1321 tcactgcaaa atttatatat ttttattata tcataaaatt caaactataa aattaaaatg
     1381 gaataattta tcaatttaag aacacctaca tatttgtaaa tacttactat attatctatt
     1441 ctaataattc ttcttctagc tggaactaat ataaaaatca tctctgaaag attaggacat
     1501 actaatataa aaataactat gaatag
//
LOCUS       DAEPID010000189         1520 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.195, whole genome shotgun sequence.
ACCESSION   DAEPID010000189 DAEPID010000000
VERSION     DAEPID010000189.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 1520)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1520)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1520
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.195"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            <1..196
                     /locus_tag="KR257_003829"
     rRNA            <1..196
                     /locus_tag="KR257_003829"
                     /product="23S ribosomal RNA"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF02541"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: cmsearch."
                     /db_xref="RFAM:RF02541"
     gene            324..440
                     /gene="rrf"
                     /locus_tag="KR257_003830"
     rRNA            324..440
                     /gene="rrf"
                     /locus_tag="KR257_003830"
                     /product="5S ribosomal RNA"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00001"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: cmsearch."
                     /db_xref="RFAM:RF00001"
     gene            448..522
                     /locus_tag="KR257_003831"
     tRNA            448..522
                     /locus_tag="KR257_003831"
                     /product="tRNA-Asn"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:480..482,aa:Asn,seq:gtt)
     gene            528..613
                     /locus_tag="KR257_003832"
     tRNA            528..613
                     /locus_tag="KR257_003832"
                     /product="tRNA-Leu"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:562..564,aa:Leu,seq:taa)
     gene            629..704
                     /locus_tag="KR257_003833"
     tRNA            629..704
                     /locus_tag="KR257_003833"
                     /product="tRNA-Met"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:662..664,aa:Met,seq:cat)
     gene            712..786
                     /locus_tag="KR257_003834"
     tRNA            712..786
                     /locus_tag="KR257_003834"
                     /product="tRNA-Glu"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:745..747,aa:Glu,seq:ttc)
     gene            801..874
                     /locus_tag="KR257_003835"
     tRNA            801..874
                     /locus_tag="KR257_003835"
                     /product="tRNA-Gly"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:833..835,aa:Gly,seq:tcc)
     gene            880..955
                     /locus_tag="KR257_003836"
     tRNA            880..955
                     /locus_tag="KR257_003836"
                     /product="tRNA-Val"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:913..915,aa:Val,seq:tac)
     gene            961..1037
                     /locus_tag="KR257_003837"
     tRNA            961..1037
                     /locus_tag="KR257_003837"
                     /product="tRNA-Asp"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:995..997,aa:Asp,seq:gtc)
     gene            1048..1122
                     /locus_tag="KR257_003838"
     tRNA            1048..1122
                     /locus_tag="KR257_003838"
                     /product="tRNA-Gly"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:1080..1082,aa:Gly,seq:gcc)
     gene            1132..1205
                     /locus_tag="KR257_003839"
     tRNA            1132..1205
                     /locus_tag="KR257_003839"
                     /product="tRNA-Arg"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:1166..1168,aa:Arg,seq:tct)
BASE COUNT          446 a          304 c          356 g          414 t
ORIGIN      
        1 ctgccaaggg catggctggg tagctatgta cggaatggat aagcgctgaa agcatctaag
       61 cgcgaagcca acttcaagat aagatttccc accgcaaggg taagacccca gaaagactat
      121 ctggttgata ggtcgaaggt gtaagtgcag caatgtattt agcttatcga tactaatagg
      181 tcgaggactt gaccaatatt tatttgatgt tcattcatta agatatatgt gtagttttta
      241 gagtgctaac tctaaagaaa ctagtattgc taggttctat aaacttatta aaaacttaat
      301 agaaatatta agcataaaga ttatgtggtt acaatagcag agaggataca cctgttccca
      361 tttcgaacac agaagttaag ctccctagcg ctgatggtac ttggtgggaa actgcctggg
      421 agagtaggac gtagccacgt taaatgttcc aaggtagctc aacggtggag caaccggctg
      481 ttaaccggta ggctgtgggt tcgagcccca cccttggagc caaaaaagcc gaagtggcgg
      541 aactggcaga cgcacaggac ttaaaatcct gcgggactta cctctcgtac cggttcgatt
      601 ccggtcttcg gcacttataa aacaatatcg cggggtggag cagttggcag ctcgtcgggc
      661 tcataacccg aaggtcgtag gttcaagtcc tgcctccgca accattaaaa cggctcgttg
      721 gtcaagaggt taagacaccg ccctttcacg gcggtaacag gggttcaatt cccctacgag
      781 tcaccaattc aattaaatat gcgggtgtag ctcaatggta gagttctggc cttccaagcc
      841 agctgtgagg gttcgatccc cttcacccgc tccaaaaatg ggaccatagc tcagctggga
      901 gagcacctgc cttacaagca gggggtcaca ggttcgagcc ctgttggtcc caccattcgc
      961 ggcctggtag ttcagttggt tagaatgcca gcctgtcacg ctggaggtcg agggttcgag
     1021 ccccttccag gtcgccaaat taaataagcg ggaatagttc agtggtagag cgcaaccttg
     1081 ccaaggttga agtcgcgagt tcgaatctcg tttcccgctc cataataact tgggtgcata
     1141 gctcagctgg atagagcaac gcccttctaa ggcgtgtgtc cggggttcga atccctgtgc
     1201 gctcattaag aaaagtttac tataaattat agtaaacttt tatattgttt aaaaagacac
     1261 aggaaacatg tatattacct gtgtcttttt atttataaac tttaaactat gtaaaaatta
     1321 cagtatattc taatagagtt acagtatatt cattaatatt gtaaacatac ggagggtaat
     1381 gtataatagt ctacaagatg tttatgaagg catcagttaa atataataaa tataactaat
     1441 tagtaagagt tatatacatt atattgtata ctttatggta tttatatatt gaaataactt
     1501 atgaaattat ttataaagag
//
LOCUS       DAEPID010000190         1492 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.196, whole genome shotgun sequence.
ACCESSION   DAEPID010000190 DAEPID010000000
VERSION     DAEPID010000190.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 1492)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1492)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1492
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.196"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            complement(658..1368)
                     /locus_tag="KR257_003840"
     CDS             complement(658..1368)
                     /locus_tag="KR257_003840"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888406.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HBH0032458.1"
                     /translation="MTSICICDDEKQQRNMLNKIITREMDLWGYPYQIKEYSNGESLV
                     YNLEHENYYIDIIFLDIELGKSNGVDIAKTIRKHSKDTIIIFVTGFSDYVFHGYDVGA
                     LNYILKPYKTEKICKVLKEALKKLEQWKENFITVQIGTNLCKINTKDILYFKSELRKL
                     TVVTFDKTLEYYGKLNDMETVLPSNFIRTHQRYIVNLNHVDSITQTYAKVQNEKIPIS
                     RKKYQEVVGKFTRYMLEP"
BASE COUNT          583 a          180 c          174 g          555 t
ORIGIN      
        1 cgaatagtgt aaacaaaata tttacggggt cggaaagcca tattatcatt tgactaataa
       61 tagagtagcc caaaatcaat atgattttga aaatccaatg attcctaaag tctataaaat
      121 aggaagtcaa cgtataaaga aaaaaggcta tgaaaatatt gattaatatt agaataaaat
      181 ttatgcttgt agagattaaa gaataagtgc ccatttaata tacctttcta ttaattaaga
      241 ttctggaaac taagttttaa aaaattaaat cttaaaaatt aaaattctgg aaattaaatt
      301 tcaaagaatt gattttgaaa aataaaattc tagagattga acttcaaaaa attgagtttt
      361 aaaagattga aattttaaaa attaagtttc aaaaaattaa atttgaaaaa aaactctaaa
      421 aactaagctt caaaaaatta aattttgaaa gattgaaatt ctagaaacta agctttaaaa
      481 aattaagttt gaaaaaacaa aactctaaaa actaagcttc aaaaaattaa attttgaaag
      541 attgaaattc tagaaattaa tcttcaaaaa attaaatttg aaaaaacaaa actctaaaaa
      601 ctaagcttta aaaagttaag tttcaaaaat aaaattctag agattgaact tcaaaaatta
      661 aggttctaac atataccttg taaattttcc tacaacctct tgatattttt tacggcttat
      721 aggaattttt tcattctgaa ctttggcata agtttgagtt atactatcta catggtttag
      781 attgacaata tacctttgat gcgtacgtat aaaattagag ggaagaacag tttccatatc
      841 atttaatttt ccgtagtatt ctaatgtttt atcaaaggta actacagtta attttcttag
      901 ctcactttta aagtagagga tatcttttgt attaatttta caaagattag ttccaatctg
      961 aactgtaata aagttttctt tccattgttc taattttttt agtgcttctt ttaatacttt
     1021 acatattttt tcagttttat aaggttttaa gatgtagttc aaagctccta catcatatcc
     1081 atgaaataca tagtcagaaa aacctgtgac aaagatgatt atagtatcct ttgaatgttt
     1141 tcgtatagtt tttgctatgt caacgccatt actttttcca agttcaatat ctaaaaaaat
     1201 aatatctatg taataatttt cgtgttctag attgtatact agactttctc catttgaata
     1261 ttcttttatt tggtaggggt agccccacaa atccatttct cttgtaatga ttttattcag
     1321 catgtttctt tgttgttttt catcatcaca aatacaaatc gaagtcaatt ttttatctcc
     1381 tttcaaattt tatatttata tagttaagta tataatatat tttgctacct agatatataa
     1441 aatgaaataa caattatatc cagatagcaa aataaaattt tttatattag ta
//
LOCUS       DAEPID010000191         1382 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.198, whole genome shotgun sequence.
ACCESSION   DAEPID010000191 DAEPID010000000
VERSION     DAEPID010000191.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 1382)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1382)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1382
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.198"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            complement(<1..659)
                     /locus_tag="KR257_003841"
     CDS             complement(<1..659)
                     /locus_tag="KR257_003841"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888853.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phage tail protein"
                     /protein_id="HBH0032459.1"
                     /translation="MAIDKSYYTIITDVGKAKIANASVTGNKVGFVKIQLGDGGGSEY
                     TPTESQTALKNVVWEGNIGNTTTDETAPNCIILESLIPSSVGGFMIREIGYLDDENNL
                     IAISKYKECYKPSIEQGAVVDMKVKTVLIVSNVNNIELKIDPTIIFATLKDIQDLETK
                     IGTVNTKIDTTKTELTNNLETAKTELNTRIDTENEKQNIKIDQLIAGGSNVASTQTIT
                     I"
     gene            complement(671..1288)
                     /locus_tag="KR257_003842"
     CDS             complement(671..1288)
                     /locus_tag="KR257_003842"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861041.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YmfQ family protein"
                     /protein_id="HBH0032460.1"
                     /translation="MDKEINLINYLPQILQDKEEYIKVFNVGNKEIKILHDKLKDLSN
                     DQFLEDLTISGIKRWEKIMSITPKSNESLEDRRFRIFSKYISKLPYSERFLRNWLDSI
                     VGEGNYELTINNATYNIHLESDARNQDWFEEVHSFVSNIKPCNMTLDYTRVLISKDNY
                     MNFGITTLMGQEITIYPWSPPDIETYGEIDVLTGNGVGYQEITIF"
BASE COUNT          394 a          254 c          152 g          582 t
ORIGIN      
        1 tcaattgtta ttgtttgagt agatgccaca ttagagccac ctgcaataag ttggtcaatt
       61 ttaatatttt gtttctcatt ttctgtgtca attctagtat ttaactctgt tttagcagtt
      121 tctaaattat ttgttaattc tgttttagtt gtatctattt tagtattaac agtacctatt
      181 ttagtttcta agtcttgtat atctttgagt gttgcaaaga ttattgttgg gtcaatttta
      241 agttctatat tatttacatt agatacaata agcacagttt taaccttcat gtctaccact
      301 gcaccttgtt ctatagaagg tttataacac tctttgtatt tagaaatggc aattaaatta
      361 ttttcatcat ctaaatatcc tatttctctt atcataaatc cgcctacact tgatggtatt
      421 aaactctcta atattataca atttggtgca gtttcatctg tagttgtatt tccaatattg
      481 ccttcccata ccacgttttt gagagctgtc tgactctcag ttggagtata ttcactccct
      541 cctccatcac caagttgaat ttttacaaat cccactttat tacctgtgac acttgcattt
      601 gctatctttg cttttcctac atctgtaatt atagtgtaat aacttttatc tatagccaat
      661 atatcacctc ctaaaatatt gttatctctt ggtatccaac tccattgcca gttaatacat
      721 caatttctcc ataagtttct atatctggtg gactccaagg gtatatagtt atttcttgac
      781 ccattagggt tgttatacca aaattcatat aattgtcttt gcttataagc actctagtgt
      841 aatctaaagt catattacat ggcttaatat tacttacaaa agaatgaact tcctcaaacc
      901 aatcttgatt tctagcatca ctttcaagat gtatattata agtagcatta ttaatagtta
      961 actcataatt accttctcca actatactat ctagccaatt ccttaaaaat ctctctgagt
     1021 aaggtaattt acttatatat ttactaaaaa tcctaaacct tctatcttct aaactctcat
     1081 tacttttagg agttatagac attatctttt cccatctttt tataccactt atagttaggt
     1141 cctctaaaaa ctggtcattt gataggtcct ttaatttatc atgtaatatt tttatttctt
     1201 tatttcctac attaaatact tttatatatt cttctttatc ttgtagaatt tgtggtaagt
     1261 aatttattag attaatctct ttatccaact acctcacctc tcactactat actgttacta
     1321 tttattgtta gattagattt aacctcattt atcattgtat ttgcaatgtc taatactcca
     1381 tc
//
LOCUS       DAEPID010000192         1146 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.199, whole genome shotgun sequence.
ACCESSION   DAEPID010000192 DAEPID010000000
VERSION     DAEPID010000192.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 1146)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1146)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1146
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.199"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            complement(94..465)
                     /locus_tag="KR257_003843"
     CDS             complement(94..465)
                     /locus_tag="KR257_003843"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861014.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0032461.1"
                     /translation="MFNIYKVKIKTKRTLEQVRNQSVDFEYSEKGLKNTLKYYNLIDD
                     LKVIVVKFGDEYCLANYNEEDRKIIMEAHYLLEQDEYTGCYINEYERFKKDWENGNCD
                     GEACMVFSDDEIEIIEKLREG"
     gene            complement(502..831)
                     /locus_tag="KR257_003844"
     CDS             complement(502..831)
                     /locus_tag="KR257_003844"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018112745.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0032462.1"
                     /translation="MKIFLLTILLIIICILANYVKNRIYKKSINNLKYKYSVGEKIIY
                     HQINCYYNRMVGCEILEKCYSTKFRKRNTPLYKVKAYVGDNDTTWVIPEWRIECLATT
                     YGEFPKY"
     gene            complement(913..>1146)
                     /locus_tag="KR257_003845"
     CDS             complement(913..>1146)
                     /locus_tag="KR257_003845"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729497.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nucleoid-associated protein"
                     /protein_id="HBH0032463.1"
                     /translation="KDSFKEHMEEKGLVEGFSIDKKWVDKKLKKRNIKTDNGFEIKGN
                     LTDFEDPMKYTVRQNQNGSIDIVIKNVTFYEEK"
BASE COUNT          337 a          221 c           88 g          500 t
ORIGIN      
        1 ggttattgct aattacaaag tcatagttga cacatctttc atcacacttt ttatgaatta
       61 atcttttttt cattttaatt cttttattca tatttaaccc tcccttagct tctcaattat
      121 ctcaatttca tcatctgaaa ataccataca ggcttcccca tcacaattac cattttccca
      181 atctttttta aatcgttcat attcatttat ataacatcca gtatattcat cctgctctaa
      241 aagataatgt gcttccatta ttatttttct atcttcttca ttgtaattag ctagacaata
      301 ttcatctcca aatttaacta ctattacttt taaatcatca atcaagttat agtatttcag
      361 agtatttttt aatccttttt ctgaatactc aaagtctacg ctttgatttc ttacctgctc
      421 caatgttctt ttagtcttta ttttcacttt atagatgtta aacataattt acaatctcct
      481 tctccagcca atttttatta tttaatattt aggaaattct ccataagtcg tagcaagaca
      541 ttcaattctc cactctggta taacccatgt tgtatcgtta tcacctacat atgcttttac
      601 tttataaagc ggggtatttc tttttctaaa tttcgtacta taacattttt ctaaaatttc
      661 acaaccaacc attctgttat agtaacagtt tatttgatga tatataatct tttcccctac
      721 agaatattta tattttagat tatttataga ttttttatat atgcgatttt tcacataatt
      781 tgctaatata caaataatta ttagcagtat agtcaataaa aaaatcttca taagttattc
      841 ctcctaacta gtttaaattt acatcctctt attatttact tctccttctc tagccaatag
      901 tcacatgagt acctactttt cctcataaaa tgttacattc ttaataacta tatctataga
      961 cccattttga ttttgtctta ctgtatattt cattgggtcc tcaaaatcag ttaagttacc
     1021 ttttatttca aagccattgt cagtttttat atttctcttt ttaagctttt tatcaaccca
     1081 ttttttatct atactaaatc cttcaacaag acctttttct tccatatgtt ctttaaaact
     1141 atcttt
//
LOCUS       DAEPID010000193         1092 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.200, whole genome shotgun sequence.
ACCESSION   DAEPID010000193 DAEPID010000000
VERSION     DAEPID010000193.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 1092)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1092)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1092
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.200"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            413..880
                     /locus_tag="KR257_003846"
     CDS             413..880
                     /locus_tag="KR257_003846"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860652.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="VOC family protein"
                     /protein_id="HBH0032464.1"
                     /translation="MKFLNVLIVVEDIEKSKKFYYDVLGLKVICDFGENVVLEGNISL
                     QEKKLWLEFINKSDSEVKFNGNDAELYFEEDYFDTFVERLSTMRDIDYVHLAIEHRWG
                     QRAIRFYDLDGHIIEVGETMSSVCRRFLDSGLSIDEVAKRMDVTVEYIESVLE"
BASE COUNT          419 a           73 c          179 g          421 t
ORIGIN      
        1 aaaactaaat tagaagaact aaaaactata tttttattaa ttagaatatt tgaataatct
       61 ctttaatcat ataaaataca tatgcttgta atatttaaag gtgatattaa tattattagt
      121 gtatattaat attctcttga aattaaaaaa acatagatat ttcagtaatc taaaatagtc
      181 tacaaaaata acagttttag caaaattaat aagaatacat atagatttaa acctaaaagt
      241 atgaatgtgt ctgtttttta caagattaaa atttatatta tatgatacaa ttaacttaac
      301 tatttcaata agacttataa tttttttctt tatactagac cttattgaaa cctttatagt
      361 ttaattctaa ttatatatta taaataaagt atgtgtatat taaggaggta atatgaagtt
      421 tttaaatgtt ttaatagtag ttgaagatat tgagaaatca aaaaagtttt attatgatgt
      481 tttggggtta aaggtaatct gtgattttgg agaaaatgtt gtattagaag ggaatatatc
      541 attacaagaa aaaaagcttt ggttagagtt tattaataag agtgacagtg aagttaagtt
      601 caatggaaat gatgctgagc tgtattttga ggaagattat tttgatactt ttgttgaaag
      661 attgagtaca atgagagata tagattatgt tcatctagct atagagcata ggtggggtca
      721 aagagcaatt agattttatg atttagatgg gcatattatt gaggttggag aaactatgtc
      781 atctgtgtgt agacgttttt tagatagtgg tctttcaata gatgaggtag ctaaaagaat
      841 ggatgtaact gtcgaatata ttgaatcagt tttagaatag atggattata ttaaagtaaa
      901 actatatttt gtatagaagt aagggctgta agtaaacttg tatggaaaca aatttactta
      961 cagtttttgt ttttgtaaga tacagaatat aatatttgtt ataattttat ttggattttt
     1021 aaaaagtgca tgattttcct tacatattat aatagaattt aatatttatt ggatgattta
     1081 aatttagaaa aa
//
LOCUS       DAEPID010000194          825 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.205, whole genome shotgun sequence.
ACCESSION   DAEPID010000194 DAEPID010000000
VERSION     DAEPID010000194.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 825)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 825)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..825
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.205"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            202..708
                     /locus_tag="KR257_003847"
     CDS             202..708
                     /locus_tag="KR257_003847"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861543.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flavin reductase"
                     /protein_id="HBH0032465.1"
                     /translation="MGFREVKIEELQFNPFTKIGKEWLLITAGDSEKFNTMTASWGGV
                     GVYWGKNVVTTYIRPQRYTKEFVDSNDTFTIAFFDETYREALNICGTISGRDINKIEK
                     AGLTPYFVDDTVAFEEANMIIVCKKLYHGNMPPENFDAKENDKKWYPEKDYHTMYISE
                     IIKVLVKE"
BASE COUNT          335 a           82 c          132 g          276 t
ORIGIN      
        1 atactttata atcaatatat tttatctata ttttacactt ataaaatatg aaaactactt
       61 attgcgaaag taattgattt gttgtattat aatttacatg aattatgtag gacaatcaaa
      121 agtcagtatt ataagagtac atatattcaa atttttaaca attaatttat ataattaaaa
      181 aatgaagggt aggatgaagt catgggtttt agagaagtaa aaattgagga attacagttt
      241 aatccattta ctaagattgg caaagaatgg ttacttataa cagctggtga ttcagaaaag
      301 tttaacacaa tgactgctag ctggggtggt gttggagtct attggggtaa aaatgttgtt
      361 acaacttaca taagaccaca gagatataca aaagaatttg tagatagtaa tgatacattt
      421 acaattgcct tctttgatga aacgtataga gaagctttaa atatttgtgg cactatttct
      481 ggtagagata taaataaaat agaaaaagca ggacttacac catattttgt ggatgatacg
      541 gtagcttttg aagaagctaa tatgattata gtatgtaaaa agctatatca tggtaatatg
      601 ccaccagaaa actttgatgc taaagaaaat gataaaaaat ggtatccaga gaaagactat
      661 catactatgt acatttcaga aattataaaa gttcttgtaa aagaataatt ataataaaaa
      721 atatatgaaa agaacttatt ataagtaaat gactgtgctt tcttatctga tatctaagta
      781 gatgctacta actaaataaa tattaatttt aaataaatac tatta
//
LOCUS       DAEPID010000195          736 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.207, whole genome shotgun sequence.
ACCESSION   DAEPID010000195 DAEPID010000000
VERSION     DAEPID010000195.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 736)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 736)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..736
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.207"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            <1..624
                     /locus_tag="KR257_003848"
     CDS             <1..624
                     /locus_tag="KR257_003848"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728456.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="terminase large subunit"
                     /protein_id="HBH0032466.1"
                     /translation="AYYRRMQMRKEQDPEGYKVYGLGEWGETGGAILKNYVIHEFTTE
                     FEYFDNMRLSQDFGFNHANVVLRIGFKDGELYICNEIYVHEMDTSEIIKIANSIGLEK
                     TLFMYCDSAEPDRIKMWKNAGYKAKGVKKGPGSVKAQIDYLKQLRIHVHPSCTNTIKE
                     IQQWKWKQDERTGLYLDEPVEFMDDAMAALRYSIDNKLKNNGISFLK"
BASE COUNT          305 a           83 c          147 g          201 t
ORIGIN      
        1 gcttactaca gaagaatgca aatgagaaaa gagcaagacc cagaagggta caaagtctat
       61 ggtcttggag aatggggaga aactggtgga gcaatactta aaaattatgt tatacatgaa
      121 tttactacag aatttgagta ttttgacaat atgaggttat cacaagactt tggatttaac
      181 catgcaaatg tagtacttag aattggcttt aaggatggag agttatatat atgtaacgaa
      241 atatatgtac atgaaatgga tacctcagaa atcataaaga ttgcaaatag tataggttta
      301 gaaaagactc tatttatgta ctgtgatagt gctgaaccag atagaattaa gatgtggaag
      361 aatgcaggat ataaagctaa aggagttaaa aaagggccag gaagtgttaa agctcaaata
      421 gattatttga aacaattaag aatacatgta catcctagtt gcactaatac cataaaagaa
      481 atacaacaat ggaaatggaa acaagacgaa agaactggat tatatcttga tgaaccagtt
      541 gagtttatgg atgatgcaat ggctgctctt agatattcta tagataataa gcttaaaaat
      601 aatggaataa gcttcttaaa gtaaaggagg tgttaaatat ttatataagt gaaacagatt
      661 taataaaagt tcagttaaaa aaagagagca cctttaacct agtaaaagtc atagaacact
      721 acatcttaaa acatag
//
LOCUS       DAEPID010000196          736 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.208, whole genome shotgun sequence.
ACCESSION   DAEPID010000196 DAEPID010000000
VERSION     DAEPID010000196.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 736)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 736)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..736
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.208"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            <1..624
                     /locus_tag="KR257_003849"
     CDS             <1..624
                     /locus_tag="KR257_003849"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728456.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="terminase large subunit"
                     /protein_id="HBH0032467.1"
                     /translation="AYYRRMQMRKEQDPEGYKVYGLGEWGETGGAILKNYVIHEFPTE
                     SEYFDNMRLSQDFGFNHANVVLRIGFKDGELYICNEIYAHEMDTSEIIKIANSIGLEK
                     TLFMYCDSAEPDRIKMWKSAGYKAKGVKKGPGSVKAQIDYLKQLRIHVHPSCTNTIKE
                     IQQWKWKQDERTGLYLDEPVEFMDDAMAALRYSIDNKLKNNGISFLK"
BASE COUNT          304 a           85 c          149 g          198 t
ORIGIN      
        1 gcttactaca gaagaatgca aatgagaaaa gagcaagacc cagaagggta caaagtctat
       61 ggtcttggag aatggggaga aactggtgga gcaatactta aaaattatgt tatacatgaa
      121 tttcctacag aatctgagta ttttgacaat atgaggttat cacaagactt tggatttaac
      181 catgcaaatg tagtacttag aattggcttt aaggatggag agttatatat atgtaacgaa
      241 atatatgcac atgaaatgga tacctcagaa atcataaaga ttgcaaatag tataggttta
      301 gaaaagactc tatttatgta ctgtgatagt gctgaaccag atagaattaa gatgtggaag
      361 agtgcaggat ataaagctaa aggagttaaa aaaggaccag gaagtgttaa agctcaaata
      421 gattatttga aacaattaag aatacatgta catcctagtt gcactaatac cataaaagaa
      481 atacaacaat ggaaatggaa acaagatgaa agaactggat tatatcttga tgaaccagtt
      541 gagtttatgg atgatgcaat ggctgcgctt agatattcta tagataataa gcttaaaaat
      601 aatggaataa gcttcttaaa gtaaaggagg tgttaaatat ttatataagt gaaacagatt
      661 taataaaagt tcagttaaaa aaagagagca ccattaacct agtaaaagtc atagaacact
      721 acatcttaaa gcatag
//
LOCUS       DAEPID010000197          636 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.211, whole genome shotgun sequence.
ACCESSION   DAEPID010000197 DAEPID010000000
VERSION     DAEPID010000197.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 636)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 636)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..636
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.211"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            complement(<1..634)
                     /locus_tag="KR257_003850"
     rRNA            complement(<1..634)
                     /locus_tag="KR257_003850"
                     /product="23S ribosomal RNA"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF02541"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: cmsearch."
                     /db_xref="RFAM:RF02541"
BASE COUNT          140 a          175 c          117 g          204 t
ORIGIN      
        1 ctacttaacg taactcgttg gcccgttcta caaaaagtac gcggtcacac aagaaatgtg
       61 cttccacagc ttgtaagtgc agggtttcag gttctatttc actcccctcc cggggttctt
      121 ttcacctttc cctcacggta ctatacgcta tcggtcacta ggtagtattt agccttggag
      181 ggtggtccct cctgcttccc acagggtttc acgtgtcccg tggtactctg gatcatatct
      241 aaagtcttct cgtttaacat acaggactat taccttctgt ggtgggtctt tccaaacctc
      301 ttcaattacg atacctcttc gttatgatat gtccgcaacc ccaataaaga aaactttatt
      361 ggtttgggct aatccgcgtt cgctcgccgc tacttacgga atcgaatttc tttctcttcc
      421 ttcaggtact tagatgtttc agttccctga gttcccctca ttaagctatg tattcactta
      481 atgatactta gacattactc taagtgagtt tcctcattcg gaaatcttcg gatcaaagtt
      541 tacgtgcaac tccccgaagc ttatcgcagc ttatcacgtc cttcatcggc tcctagtgcc
      601 aaggcatccg ccctgcaccc ttaataactt gaccag
//
LOCUS       DAEPID010000198          611 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.213, whole genome shotgun sequence.
ACCESSION   DAEPID010000198 DAEPID010000000
VERSION     DAEPID010000198.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 611)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 611)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..611
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.213"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            <1..>611
                     /locus_tag="KR257_003851"
     rRNA            <1..>611
                     /locus_tag="KR257_003851"
                     /product="23S ribosomal RNA"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF02541"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: cmsearch."
                     /db_xref="RFAM:RF02541"
BASE COUNT          172 a          126 c          179 g          134 t
ORIGIN      
        1 tttaactgag cgttcagtta cttgacgtag acccgaaacc gggcgaccta cccatgagca
       61 ggatgaagcg aaagtaaaat ttcgtggagg tccgaaccca cgagcgttga aaagctcggg
      121 gatgacttgt gggtagcggt gaaattccaa tcgagcccgg agatagctgg ttctccccga
      181 aatagcttta gggctagcct caaggtgaga gatacggagg tagagcactg aatgtcctag
      241 ggggtattgc acctaccgaa gactatcaaa ctccgaatgc cgtcatctta tacttgggag
      301 tcagactgtg ggtgataaga ttcatagtcg aaagggcaac agcccagatc gtcagctaag
      361 gtccctaaat gtaagttaag tggtaaagga tgtgggattg cacagacaac caggatgttg
      421 gcttagaagc agccactcat tcaaagagtg cgtaatagct cactggtcga gtgatcctgc
      481 gccgaagatt tccggggcta aaacttacta ccgaagctac ggcatcagta atgatgggta
      541 ggggagcttc ccatacgggt tgaagcatga ccgtaaggac atgtggacag tatgggagtg
      601 agaatgttgg c
//
LOCUS       DAEPID010000199          577 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.215, whole genome shotgun sequence.
ACCESSION   DAEPID010000199 DAEPID010000000
VERSION     DAEPID010000199.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 577)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 577)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..577
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.215"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            <1..>577
                     /locus_tag="KR257_003852"
     rRNA            <1..>577
                     /locus_tag="KR257_003852"
                     /product="16S ribosomal RNA"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00177"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: cmsearch."
                     /db_xref="RFAM:RF00177"
BASE COUNT          154 a          121 c          190 g          112 t
ORIGIN      
        1 caggatggac ccgcgtctga ttagctagtt ggtaaggtaa cggcttacca aggcgacgat
       61 cagtagccga cctgagaggg tgatcggcca cattggaact gagacacggt ccaaactcct
      121 acgggaggca gcagtgggga atattgcaca atgggcgaaa gcctgatgca gcaacgccgc
      181 gtgagtgatg aaggccttcg ggtcgtaaaa ctctgtcctc aaggaagata atgacggtac
      241 ttgaggagga agccccggct aactacgtgc cagcagccgc ggtaatacgt agggggctag
      301 cgttatccgg atttactggg cgtaaagggt gcgtaggcgg tctttcaagt caggagtgaa
      361 aggctacggc tcaaccgtag taagctcttg aaactgggag acttgagtgc aggagaggag
      421 agtggaattc ctagtgtagc ggtgaaatgc gtagatatta ggaggaacac cagttgcgaa
      481 ggcggctctc tggactgtaa ctgacgctga ggcacgaaag cgtggggagc aaacaggatt
      541 agataccctg gtagtccacg ctgtaaacga tgagtac
//
LOCUS       DAEPID010000200          554 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.217, whole genome shotgun sequence.
ACCESSION   DAEPID010000200 DAEPID010000000
VERSION     DAEPID010000200.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 554)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 554)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..554
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.217"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            <1..>554
                     /locus_tag="KR257_003853"
     rRNA            <1..>554
                     /locus_tag="KR257_003853"
                     /product="23S ribosomal RNA"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF02541"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: cmsearch."
                     /db_xref="RFAM:RF02541"
BASE COUNT          159 a          121 c          158 g          116 t
ORIGIN      
        1 gtagcgaagt agctgatttc acactgtcaa gaaaagtctc tatcgaggtt aaaggtaccc
       61 gtaccgcaaa ccgacacagg tgggtgagga gagtatccta aggccagcga gagaactgtt
      121 gttaaggaac tcggcaaaat gaccccgtaa cttagggata aggggtgcca ccatcaggtg
      181 gccgcagaga ataggcccaa gcgactgttt accaaaaaca taggtttctg ctaagtcgca
      241 agacgatgta taggagctga cgcctgcccg gtgctggaag gttaagggga tctgttagag
      301 caatcgaagc agtgaactta agccccagta aacggcggcc gtaactataa cggtcctaag
      361 gtagcgaaat tccttgtcgg gtaagttccg acccgcacga aaggcgtaac gatttgggca
      421 ctgtctcaac aacagactcg gtgaaattgt aattccggtg aagatgccgg atacctgcga
      481 caggacggaa agaccccatg gagctttact gtagcttgac attgggtctt ggtactacat
      541 gtacaggata ggtg
//
LOCUS       DAEPID010000201          533 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.219, whole genome shotgun sequence.
ACCESSION   DAEPID010000201 DAEPID010000000
VERSION     DAEPID010000201.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 533)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 533)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..533
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.219"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            <1..>533
                     /locus_tag="KR257_003854"
     CDS             <1..>533
                     /locus_tag="KR257_003854"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728456.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phage terminase large subunit"
                     /protein_id="HBH0032468.1"
                     /translation="RAMKGSAGSGKSVNVAQDYILKLGDKKYQGANLLVVRKSEATHK
                     YSTYAELTGAINRIYGKQADKYWKTTLNPLEIKSKVTGNSIIFRGVNDAKQREKLKSI
                     NFSKGKLTWVWCEEATELMESDIDILDDRLRGILTNPNLYYQMTFTFNPVSATHWIKR
                     KYFDYKNDDIFTHHSTYL"
BASE COUNT          214 a           69 c           96 g          154 t
ORIGIN      
        1 agagcaatga aaggttcagc agggagtgga aaatctgtta atgtagcaca agactatata
       61 ctaaagttag gagataagaa gtatcaagga gctaatctat tagtagttag aaagtcagaa
      121 gctacacata agtattcaac gtatgcagag cttacaggag ctataaatcg tatttatggt
      181 aaacaagctg ataagtattg gaaaactact ttaaatcctt tagaaattaa gagtaaagtt
      241 actggtaact ctataatttt cagaggagtt aatgatgcaa aacaaagaga aaaattaaaa
      301 tcaattaact tctcgaaagg aaaattaaca tgggtttggt gtgaagaagc tacagaactt
      361 atggaaagtg acatagacat actagatgac cgtttaagag gtattttaac taatcctaac
      421 ctatactatc aaatgacatt tacatttaat ccagtctcag ctactcattg gataaaaaga
      481 aagtattttg actataaaaa tgatgatata tttactcatc atagtactta tct
//
LOCUS       DAEPID010000202          512 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.denovo.220, whole genome shotgun sequence.
ACCESSION   DAEPID010000202 DAEPID010000000
VERSION     DAEPID010000202.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 512)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 512)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..512
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.denovo.220"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            <1..>512
                     /locus_tag="KR257_003855"
     rRNA            <1..>512
                     /locus_tag="KR257_003855"
                     /product="23S ribosomal RNA"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF02541"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: cmsearch."
                     /db_xref="RFAM:RF02541"
BASE COUNT          124 a          117 c          160 g          111 t
ORIGIN      
        1 tgggatacca cccttgtagt actgggactc taaccatagg ccatgaatct ggtcttggga
       61 cactgtcagg tgggcagttt gactggggcg gtcgcctccc aaaaggtaac ggaggcgctc
      121 aaaggttctc tcagtacggt cggaaatcgt acgtagagtg taaaggcaaa agagagcttg
      181 attgcaagac atacaggtcg agcaaggatg aaaatcggac ttagtgatcc ggtggttctg
      241 cgtggaaggg ccatcgctca acggataaaa gctaccctgg ggataacagg cttatctccc
      301 ccaagagtcc acatcgacgg ggaggtttgg cacctcgatg tcggctcatc acatcctggg
      361 gctgtagtag gtcccaaggg ttgggctgtt cgcccattaa agtggtacgc gagctgggtt
      421 cagaacgtcg tgagacagtt cggtccctat ccgtcgcagg cgtaggaaat ttgagaagac
      481 ctgtccttag tacgagagga ccgggatgga cg
//
LOCUS       DAEPID010000203        12273 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.guided.103, whole genome shotgun sequence.
ACCESSION   DAEPID010000203 DAEPID010000000
VERSION     DAEPID010000203.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 12273)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 12273)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..12273
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.guided.103"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            complement(741..1556)
                     /locus_tag="KR257_003856"
     CDS             complement(741..1556)
                     /locus_tag="KR257_003856"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897377.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phage integrase family protein"
                     /protein_id="HBH0032469.1"
                     /translation="MVKLSDAKSWAIRMSEDGCAYKSIDNYKRSLKASFFMAIQDDCI
                     RKNPFNFQLSDVLEDTTEPKIALTPEQEMGLLSFMESDKTYCKYYDDVVILLETGLRI
                     SELCGLTLELDMKNKAIMVDHQLLSDTKIGYYVEVPKTTQGKREIPMTERAYQSFERI
                     VERRKNAKAEPIIVDGYQNFLFLKQDGLPKQATHYQSMLRALVKKYNKTHEDKLPKIT
                     PHTFRHTLCTNMANKGMSPNILQYIMGHKNITMTLGYYAHGSFSSSRAEMERL"
     gene            1648..2916
                     /locus_tag="KR257_003857"
                     /pseudo
     CDS             1648..2916
                     /locus_tag="KR257_003857"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000331151.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding protein"
     gene            3015..3635
                     /locus_tag="KR257_003858"
     CDS             3015..3635
                     /locus_tag="KR257_003858"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423956.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Crp/Fnr family transcriptional regulator"
                     /protein_id="HBH0032470.1"
                     /translation="MHLIDFMNEDIKKKLVKKTYKKKETILFAEQENEYVILMIDGIA
                     EAFILNVKGNISTIHLYRSGSFFGEMEQFNDGKKPVEIVAFTDCNVYKLHRDDFLNWL
                     RGDFEATKFLIREISSKLVVNAELIEELSSLSVKERLLRCISLHYYRSELNLLTKKQL
                     ASEVNAPIRSINRAINECVQEHLIAYENKRFSVINQREVLKNLPTT"
     gene            3785..4189
                     /locus_tag="KR257_003859"
                     /pseudo
     CDS             3785..4189
                     /locus_tag="KR257_003859"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003433844.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="oxalate:formate antiporter"
     gene            4314..5240
                     /locus_tag="KR257_003860"
     CDS             4314..5240
                     /locus_tag="KR257_003860"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903090.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH0032471.1"
                     /translation="MSDILSRITNKIGDKNIVDKLSALSKSDLNSLLLEVFDRQANTL
                     TATDILKSYQLNRFTIPSGIDPEEIHALESKLLRKAFNMDIKTIMLSPSAPLGSCSVF
                     GSVDQYNVVSALRGTETLADPSNMLAIIIADKLKRKEENNTIPIHMATTARVIRAQNF
                     VGKGLYSHFGLYCMVSSGIDTGSYTCEKMLLEKHLNYYKDILSEIENVRFSIILRKRN
                     GYKDNDGFFDRMVETIKLIFPNIELSIHNDDVDNNYYKGINFKLSVKQGNETVEIVDG
                     GFVDWTYQMLGNKKERCLISGIGLERFLVAVS"
     gene            5254..5703
                     /locus_tag="KR257_003861"
     CDS             5254..5703
                     /locus_tag="KR257_003861"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729090.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HBH0032472.1"
                     /translation="MELIEWNYAYITDLVEFANDKEIAKNLRDNFPHPYREQNARDFV
                     SFCLATPDVKQLSYAIFYQERAIGSISLTFEEDTSINKNAELGYWLARNYWGKGIATN
                     AVKEICKIAFEKYNLNKIHANVYSYNRGSSKVLEKCGFKIEEYCHNS"
     gene            6063..6470
                     /locus_tag="KR257_003862"
     CDS             6063..6470
                     /locus_tag="KR257_003862"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897392.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sigma-70 family RNA polymerase sigma factor"
                     /protein_id="HBH0032473.1"
                     /translation="MVDEKTIEHQFDSFCKTVLRNYARDIYDENKRRNDYLVSLESLS
                     LAELSKLSILDDYDSNYICMVSYDYNIRIEDVLMAQAIGKLTKRKQDIILLSFFLNMT
                     NADIATLMDLAENTIHYHKTNALKELKELMEEH"
     gene            6472..6702
                     /locus_tag="KR257_003863"
     CDS             6472..6702
                     /locus_tag="KR257_003863"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897394.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="HBH0032474.1"
                     /translation="MKPTKEVLPFTIILLAVHGDVNAINGILKHFEHYIIRLSQKTLF
                     DEYGNPYIHVEEETKRMLGTKLITAILRFNLS"
     gene            7092..7295
                     /locus_tag="KR257_003864"
     CDS             7092..7295
                     /locus_tag="KR257_003864"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002262306.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="excisionase"
                     /protein_id="HBH0032475.1"
                     /translation="MNNTDVPIWEKYTLTIEEASKYFRIGEKKLRKLADENLDSGWVI
                     MNSNRIQIKRKQFEKIVDTLDFI"
     gene            7373..7726
                     /locus_tag="KR257_003865"
     CDS             7373..7726
                     /locus_tag="KR257_003865"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897397.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="integrase DNA-binding domain-containing protein"
                     /protein_id="HBH0032476.1"
                     /translation="MSTEKRRDNKDRILRTGESQRKDGRYAYKYVYSFGKPQFVYSWK
                     LVPTDKPPKGKRDDISLRDKEKAIQNDLDDSIDTIGKKMTVCQLYAKKNGLRKNIRLN
                     TKKGRHYLMKILNKE"
     gene            7798..8430
                     /locus_tag="KR257_003866"
     CDS             7798..8430
                     /locus_tag="KR257_003866"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003433837.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CatB-related O-acetyltransferase"
                     /protein_id="HBH0032477.1"
                     /translation="MTIPSSNKVYPRSNDYQTVYLKNVITRENIEVGDYTIYNDFYND
                     PRDFEKNNVLYHYPINNDKLIIGKFCSIACNAKFLMTSGNHSMKSKSTYTFPIFYEEW
                     KLDINHITDAWDNKGNIIIGNDVWIGYDSIIMSGVNIGDGAIIGTRAVVTNDVPPYSI
                     VGGVPAKIIKKRFNNDTISKLLEIKWWDWPYKKIQSNIKHIQSGNIDKLV"
     gene            complement(8801..9670)
                     /locus_tag="KR257_003867"
     CDS             complement(8801..9670)
                     /locus_tag="KR257_003867"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003433836.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="radical SAM protein"
                     /protein_id="HBH0032478.1"
                     /translation="MEYDMPLYRPPSEAYSLIIQVTLGCSHNKCTFCSMYKSKKFKIK
                     PLEVIKNEIDIFRRYYKHVERIFLADGDALIIPMEKLRDIILYIKEVFPECERITMYG
                     SPKSIEKKSDDELKELRKLGVKMIYLGLESGSNEVLEDIKKGFSSEQLIKVGRKVKKS
                     GIKLSATVIAGLGGTKKTHQHAVDTGKMLGAISPDYVGVLSLMVEPNTELYDLLKAGE
                     FTILEDKAVLQEIKEMIKNIDANEKIVFRSNHASNYANLKGVLPDDKQRLIDEIDYYL
                     SNQKLKREEYRRL"
     gene            complement(9767..10624)
                     /locus_tag="KR257_003868"
     CDS             complement(9767..10624)
                     /locus_tag="KR257_003868"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890403.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha/beta hydrolase"
                     /protein_id="HBH0032479.1"
                     /translation="MSKDVKVKRNKKYDTFSITMELERPLLYDEVENKDDKNNNRKFN
                     IKNKIFKGIGILFVLILLGFFIWINKTYEPQKLAKEALVSNSKVEVTVNENISFTPKG
                     RKVSKGLILYPGAKVEIESYAPLARKIAESGYEVVIVKMPLNLAILGTNKAQKVMDSY
                     NNIEHWVIGGHSLGGVAASNFARDNKLIEGVVFLASYPMGDELKELGKKVISIWGSKD
                     GVVNFKSLVESKQKLPDDTTYVEIEGGNHAQFGDYGKQKGDNDAIISQEKQLNITANS
                     IIKFLKNIS"
     gene            complement(10839..>12273)
                     /locus_tag="KR257_003869"
     CDS             complement(10839..>12273)
                     /locus_tag="KR257_003869"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729087.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=2
                     /transl_table=11
                     /product="FUSC family protein"
                     /protein_id="HBH0032480.1"
                     /translation="NYRINSISKNLKMVIFDNRKDDFYISIRGIDIMNILFSLERISL
                     ILERYKKDSKEFEDEDIKNILEESSINSKSDVLVVATKEINYIKMCLENKDTITDKEI
                     LGFRDYVIAQDTKNINLKEIYSVLENLYEFLVDYKKVKSRDEKKAERKSKIPHEFKRL
                     SIYKKNFNLNSIRFSYAVKIALATAVAGFIMDYFHLRDGRWIMLTVFSLTQPYAENCI
                     QRSRKRIEGTFIGAVIFIVLFSIIKDSTLRSLIVLLAGYINSYVVDYRKLMVCVTVSA
                     LGSAVVMGDPNVLTISRISYVALGAIIALIVNKFILPYDAKTGYQHVIEMYKGIVKNI
                     IDEVNKSIENVADVYYIKNLLLIPSLIEDRLMLINAIYKDKHQEDFLENQKLLISNMY
                     NLYINVNKNKIKDEDVEKILRDTNYISNYNVDKYDEGRSVILESIVNTKSLGDKIICL
                     NLLQTLNGVKEMYRISNITKVSIKEAA"
BASE COUNT         4217 a         1895 c         1775 g         4386 t
ORIGIN      
        1 aattggtaca caaattttag gtctaccttc tccaatagta atatttttta cttgaacttt
       61 tcttttcata ttctcctcca taatcagaaa ttctatagga ctttaaattc tattttctgc
      121 acaatttaat tatacattaa aaatactata cattataaaa atactaattt aaaaataatt
      181 tttattctaa ttcttaaaac aatcccacat attttagaaa aggtactcta taatatacaa
      241 acacttcttt tttacctaaa tttattttaa catcctataa ttttcacaat attctttaaa
      301 ttttactcat ataaacaata ttattctgga tgctaataga attaatctat aaatcatagt
      361 ataattatgc agaaataact cgaatttcac tacttatgaa gagattgaat attaatgaat
      421 ctaaatcatt tgcattactt aagagttttg actaaagttg aacaccatac aaaagtagct
      481 actcaattgt ttatacccca accaagctta agtaatgtta tatagattct cgaaaaagaa
      541 tttggtatct ttttatttga aaaacttata ttaaatttga ttatcttttc ataagttggt
      601 aaatgtcgat atatcctgta tctacaagga gtatcggcat tttctttttg gaagatactt
      661 tgcataagtt ggcatttaac cgtataagaa tgccatcaaa agtagtaaat aagtagtaaa
      721 ctctagtcat actactagga ttataaccgt tccatttcag ctctcgaaga actaaatgaa
      781 ccatgtgcat aatagccaag cgtcatagta atgtttttat gccccataat atattgcaat
      841 atattaggac tcattccttt gttagccata tttgtacaga gtgtatgcct aaaggtatgt
      901 ggcgtaatct ttggtagctt gtcctcatgg gtcttattat acttcttgac taacgctctt
      961 aacatgcttt gataatgagt tgcttgtttt ggtaatccat cttgtttaag aaataggaag
     1021 ttctggtaac catcaacaat gattggttct gctttagcgt tcttacgccg ttccacgata
     1081 cgttcaaatg attgataagc tctttcagtc attggaattt ctcgcttacc ctgtgtggtc
     1141 tttggaactt ctacataata gccaatctta gtatcactca acaattgatg gtctaccata
     1201 atggctttat ttttcatatc caattctaaa gtcaaaccgc ataattcaga aatgcgtagt
     1261 cctgtttcta agaggataac aacatcatca taatatttac aataagtctt atcgctctcc
     1321 ataaaggata ataagcccat ttcctgttct ggtgttagag cgatttttgg ttctgttgta
     1381 tcttccaaaa catcacttaa ctgaaaatta aatggattct ttctaataca gtcgtcttga
     1441 attgccatga aaaacgacgc tttcagtgag cgcttataat tgtcaatgga tttataagca
     1501 cacccatctt cactcattcg gatagcccag cttttagcgt ctgataattt aaccatatca
     1561 atgctttttg cacctagtgg gtcattgata gtatctatat tttgatttat aatttataca
     1621 tttttttaaa aacagacttt taactgtaaa gaatctatgt ataaacttag ctatgttgtc
     1681 cgtgtatcta caaaggatct tgacgagcta aaaaggcgtt gtgatgaagt caaagacttt
     1741 tacgacgact tatcactcaa gctcgtgcgt ccctttgggg atatgttggg attgcatggc
     1801 gaatttattc ctgtcagcaa acgttacatc aatgattata ttcaatatgt cacttcggat
     1861 tttttggctg gacttggttt tggagcgaca caaacccttg gcgaacatga ggatatctat
     1921 cttggctaca atctggacac tggaaagaat gtctatctaa aacctgccct tgctagtcaa
     1981 tgggtaaagg gttctattac caatgtgtta gcgtctgcgt ttatcggttc attgggtggt
     2041 ggtaaattat tcagtaacaa tatgcttgtt tactatgcgg tactattcgg cggacaggcg
     2101 gtcatagttg accctaaagc agaacgcggc aaatggaaag aaacgctacc agaaatagcc
     2161 catgagataa acattgtcaa tttaaccagt aatgatgaaa acaaaggatt gcttgaccct
     2221 tacgtcattt tgagccgtaa aaatgattct gaaagtttag cgattgatat cctaacattc
     2281 cttgctggta tctccagtcg tgacagtgat aagttcccag tgcttagaaa agcaatccgc
     2341 aatgtaaccc aaagtgaaca gcgagggtta ttacttgtca ttgatgaatt acgaaaagaa
     2401 gatacttcta tcagtaacag catagccgac catatcgaaa gttttgtaga ctatgatttt
     2461 gcacatctac tgtttggtga cggaaatgtg aagcagtcta tcagcttgga gaaacagctg
     2521 aatattattc aagttgctga cctcgtattg ccagatgcca acactagctt tgaagaatat
     2581 acaacaatag aacttcttag tgttgctatg ttgattgtta ttagtacctt tgcattagac
     2641 tttattcata ctgaccgctc tagcttcaag atagttgacc ttgacgaagc atggtctttt
     2701 ttgcaggtgg cacaaggtaa aacgctatct atgaaactgg ttagagcatc gcaagattca
     2761 caggacaaac gaattgaacg tttgaagaat tatctgactg aaaacctaca acagttgaat
     2821 actgaaatgg ttcgctcata tattcctact agttctattg tcaacagctt tctcagtttg
     2881 agcttacttt gcagaaaaat gacaactgga aaataataat ggaatagttt ctatgtaaat
     2941 atatttttac tatcttacct aactaattga aagatgatat aatttaatca aagatttggt
     3001 aaggagggat gaatatgcat ttaattgatt ttatgaatga agatattaaa aagaagcttg
     3061 ttaaaaaaac gtataaaaag aaagagacta ttctttttgc tgagcaagaa aatgaatatg
     3121 taattcttat gattgacggt attgcagaag cattcatctt aaatgtgaaa ggaaacatct
     3181 caactattca tctttataga agtggtagtt tttttggaga aatggaacaa tttaatgatg
     3241 ggaaaaaacc cgttgaaatt gtcgctttca cagattgtaa tgtatataaa cttcatagag
     3301 atgatttttt aaactggtta aggggagatt ttgaagctac aaaatttctg attcgagaaa
     3361 tatctagtaa attagttgta aatgctgaat taattgaaga attatcatct ttaagtgtta
     3421 aagaacgact tctgaggtgt atatccttac actattatag aagtgaatta aatctgctta
     3481 ccaaaaaaca gcttgctagc gaagtaaacg ctccaattag aagcattaat cgtgctataa
     3541 atgaatgtgt acaagaacat ctaattgctt atgaaaacaa aagatttagt gtaattaatc
     3601 agcgagaggt attaaagaat cttcctacaa cataagtata atttcaaaaa agtattgaat
     3661 aataattatt caatgctttt ttatttcggg tcaagtgacc tatttttttt tattttttca
     3721 ttatataata ctcctatgca taattatgtt ggattgatag ctaataaaag aaagtgagag
     3781 gtgttatact aaaaaagaag catacttccc aactccagac ttacagtgga ttgaagatag
     3841 attttggatt tgggttcatt acgcttgcac taagattgga cgtagagaac tatttgaaac
     3901 aattgatttt ttatcttttt taagacaatc agtacttgcc ccattaatac agcttctctt
     3961 aggtaaatta cctcgtggag ttagaaaaat tgaattggac gcaccccaat atattgaagc
     4021 attagaaaag acggttgcta accatgaata taaaagctgt gttaatgcat tgcaggctac
     4081 tatcaacctg tatcttgagt taagagagga attatcacaa agtcctattg tccgaaaggt
     4141 tgaagctgaa agggttgcat tacagtattt tcaagattta atcaaataaa cccaaagtaa
     4201 aaaaatattg aatagtaaat attcagtgtt ttttcatttt tggtcaaatg acctagatta
     4261 gttgttgtaa ccattctata attattttga aagtaacagt atggaggata actatgagtg
     4321 atattttaag tagaattaca aataaaattg gggataagaa tatagttgat aagttatcag
     4381 ctctatcaaa atcagatttg aactcacttc tattagaagt gtttgataga caagcaaata
     4441 ctttaactgc aactgatatt ctaaagtcat accaactaaa tagatttact atccctagcg
     4501 gtatagatcc agaagaaatt catgctttgg agtcaaaatt attgagaaaa gcattcaata
     4561 tggatatcaa gacgattatg ctttctccct ctgctccatt aggtagctgt agcgtttttg
     4621 gctccgtaga tcaatataat gtagtaagtg ctctacgagg gacagaaaca cttgcagacc
     4681 cctcaaatat gttggcaata attattgctg ataaattaaa aagaaaagaa gaaaataata
     4741 ccatacctat ccacatggct actactgcta gggtaataag agcacaaaat tttgtaggta
     4801 aaggtttata ttcacatttt ggcttatatt gtatggtttc atctggtata gatacagggt
     4861 cttacacttg tgaaaaaatg ttgttagaaa agcacttaaa ctattataaa gatatattaa
     4921 gtgaaataga aaatgttcgt ttctctatta ttctacgcaa aagaaacgga tacaaagata
     4981 atgacggatt tttcgacaga atggttgaaa ctatcaaact tatttttcct aatatagagt
     5041 tatcaattca taatgatgat gttgataata attattataa aggtatcaat ttcaaattat
     5101 cggtcaaaca aggaaatgaa accgttgaaa tagttgacgg tggatttgtt gactggactt
     5161 atcaaatgct tggaaataaa aaagaacgct gtttgataag tggtattggc ttagaaagat
     5221 ttcttgtagc tgtttcataa aaggagaaga aaaatggaac ttatagagtg gaattatgct
     5281 tatattaccg atttagttga gtttgcgaat gataaagaaa ttgcaaagaa tcttcgtgac
     5341 aacttccccc acccttatag ggagcaaaac gctagagatt ttgttagttt ttgtttggca
     5401 actccagatg ttaaacaact tagctatgct attttttatc aagaaagggc tattggaagt
     5461 atcagcctaa catttgaaga agatacctct attaataaaa atgctgaatt aggttactgg
     5521 cttgctagga actattgggg caaagggata gcaacaaatg cagtaaaaga aatatgcaaa
     5581 attgcctttg aaaaatacaa ccttaacaaa attcatgcta atgtatattc ctacaataga
     5641 gggtcaagta aagtattgga aaaatgtggt tttaagattg aagaatactg tcacaattca
     5701 taataaagaa tagaaacatg attgattgcc atgtatatag tttaattcga ccgcaatagc
     5761 atttattaga attaacctac tttttaataa cagaataagt ttttcccctc tattaatttc
     5821 ttatgcatct ttgtattttt atgaaaagct agccaatgca tatttccata catcaatatg
     5881 gtggtggctt acaaccaata taaattaaat acgttttaaa gaatacacat ttttgcccta
     5941 taggcagagt gtgtattttt ttctcttttt tttgaaattt atcgaagatt taacgccctc
     6001 ccaccgtgat aggagtaagc aaggttattt aactccttgc gatggaaaga gggtgaaatc
     6061 ttatggttga tgaaaagaca attgaacatc aattcgacag tttctgtaaa acagttttgc
     6121 gtaactatgc tagagatatt tatgacgaaa ataaacgcag aaatgattat ttggtatctc
     6181 tcgaatcttt gtcacttgca gaattaagta aattgagtat tttagatgat tatgattcta
     6241 actacatctg tatggtttct tacgactaca acatacgaat tgaagatgta ttaatggcac
     6301 aagcaatcgg aaaacttaca aaaagaaaac aagatataat tctactttca ttctttctca
     6361 acatgacaaa tgctgacata gcaacattga tggatttagc agaaaatacc atacattatc
     6421 acaaaacaaa tgcactaaaa gagttgaaag aactcatgga ggaacattga aatgaaacct
     6481 actaaagaag tattaccttt tacaattatt ttacttgctg tacatggcga tgtaaatgca
     6541 ataaacggaa tacttaaaca ttttgaacac tatatcattc gtctttcaca gaaaacttta
     6601 tttgatgaat acggaaatcc ctatattcat gtagaagaag aaacaaagcg aatgctagga
     6661 acaaaactaa tcactgctat tttgagattt aatttgtctt aatctcgccc tctctccatg
     6721 tatcaagcta tttggtacat ggagaatcac taattatttg tctataaaag cccataagct
     6781 attgtgattt tttatagaca aatcaatgcc gactgttctt tgacaactga ataaagtaga
     6841 tagatacgtt tgtgatacag atagccaaca aatactatac gccatgacct taatcaagag
     6901 agctactata tagtgatttg tgaataacct ttggaacggt tgttttgccg taacctgtac
     6961 cacagtataa tgatacacct gtatgacacg gttctgccca taagaatggg attggttaaa
     7021 ataccaatgg agcttaccaa agccatctat ctacttctga actacgaaca tagaaaggag
     7081 tgatacattc tatgaacaat actgatgtac ctatttggga aaaatatacc ttgacgattg
     7141 aagaagcgtc aaaatacttt cgtattggag agaaaaaatt acgtaaactt gctgatgaaa
     7201 accttgattc tggctgggtc attatgaata gcaatcgcat tcaaataaag agaaaacaat
     7261 ttgagaaaat cgttgataca cttgacttta tctaatgaaa ttgagcctta tatgttataa
     7321 tattcatatg acgtatcaag ctcaattcgg ttattgagag gagcttctta tcatgtcaac
     7381 tgaaaaaaga cgagataata aagatagaat tttaagaact ggagagagcc agagaaaaga
     7441 tggaagatac gcatataagt atgtatattc atttggtaaa ccacaatttg tttactcttg
     7501 gaaacttgta cctactgata aacccccaaa gggaaaacgt gatgatatat cattaaggga
     7561 taaggaaaaa gcaatacaaa atgaccttga tgatagcatt gacactattg gtaagaaaat
     7621 gacagtttgt cagttatacg ctaaaaagaa tggactaaga aagaatatcc gacttaacac
     7681 taaaaaagga cgccattatc ttatgaagat tcttaacaag gagtgattct gtgaagagat
     7741 gtattgtagt agtggaatag tcaaaaacat aatatatatt aaaggagaga tttaaatatg
     7801 actattccaa gttcaaataa ggtatatcca agaagtaatg attatcaaac tgtatatctt
     7861 aaaaatgtaa taacaaggga aaatatagaa gttggagatt acacaatata taatgacttt
     7921 tataatgacc caagagattt tgagaaaaac aatgtattgt atcattaccc tataaacaat
     7981 gataaattaa taattggtaa gttttgctca atagcatgta atgcaaaatt tctaatgact
     8041 agtggaaatc actcaatgaa atcaaaatcc acatatactt ttcccatctt ttatgaagaa
     8101 tggaaactcg atatcaacca tataacggac gcttgggaca ataagggtaa cattataatt
     8161 ggaaatgatg tgtggatagg ttatgattct ataattatgt caggtgtaaa tattggtgat
     8221 ggtgcaatta ttggaacaag agcagtagtt actaatgacg ttccaccgta ttctattgtt
     8281 ggaggagtac ctgcaaaaat tataaaaaag agatttaata atgatacaat ttcaaaatta
     8341 ttagaaatta aatggtggga ttggccatat aaaaaaattc aatcaaacat taagcatatt
     8401 caatcaggaa atattgataa attagtttaa tattttataa tttatttata ttaaacttta
     8461 ctttaataat cattttataa gagctttttc aaaatttgta tattatttta atatatataa
     8521 atttaataca acattaaata aaataaaaag taaagttact taataaaaag ttactttact
     8581 ttttattatt taaattcctg tttttattat aataggtaaa attctattaa actagttcac
     8641 attttcatta ttattgatat attatatatg aatataccat tttgtttttt aataaaaaaa
     8701 tcatgctaca tcaatagtaa gcaactatta atgtagcatg attttttgta tctaaataat
     8761 cttagtattt acctatcaat atagattgat atatcaaaaa ctatagtctt ctatattctt
     8821 ctctttttag cttttggtta cttagatagt aatcaatttc atcaattaga cgttgtttat
     8881 catcaggtaa tacacctttt aaattagcat aatttgatgc atgattactt ctaaatacaa
     8941 ttttttcatt agcatctata ttctttatca tctctttaat ttcttgtaac acagccttat
     9001 cctctagtat tgtaaactct cctgccttaa gtaaatcgta aagttcagta ttaggttcta
     9061 ccattaaact aagtacaccc acataatctg gtgaaattgc tcctaacatt tttcctgtat
     9121 caactgcatg ctgatgtgtt tttttagttc ctccaagacc tgctattaca gtggctgata
     9181 atttaatccc acttttttta acttttctac caacttttat taattgttca ctactaaaac
     9241 ctttcttaat atcttctaat acttcattgc ttccactttc aagccctaga taaatcattt
     9301 taacaccaag ttttcttaat tctttaagtt catcatcaga ttttttctct atagatttag
     9361 gagagccgta catagtaatt ctttcacact ctggaaaaac ttcttttata tataagataa
     9421 tatctcttaa tttctccatt ggtattatca atgcatctcc atctgctaag aatattcttt
     9481 ctacatgctt ataatatctt ctaaatatat caatttcatt ttttattact tctagtggct
     9541 ttattttaaa ttttttagat ttgtacatac tacaaaacgt acatttgtta tgagaacatc
     9601 ctagtgtgac ttgtattata agactataag cctcacttgg tggtctgtaa agtggcatat
     9661 cgtattccat attaaaatcc cccttgtaat aaaatattca ttctattata ttattaatat
     9721 ttactttaaa taataactta taaaattata ttttttaaat tttagtttaa gatatattct
     9781 ttaaaaattt aatgatacta ttggcagtaa tattaagttg tttttcttga cttataatag
     9841 catcattatc tcccttttgt tttccataat ctccaaattg tgcatgattt cctccttcaa
     9901 tctcaacata agttgtatca tcaggaagtt tttgttttga ttctacaaga cttttaaaat
     9961 tgactactcc atctttgctc ccccatatag atataacttt ttttcctaat tctttcaact
    10021 catcacccat tggataagaa gctaaaaata caacgccttc aattaattta ttatcacgtg
    10081 caaaatttga tgctgcaact cctcctaatg aatgacctcc tattacccaa tgttctatgt
    10141 tgttgtaaga atccataact ttctgtgcct tattagttcc aagtatagct agattaagtg
    10201 gcatctttac gattacaacc tcatatccac tttctgctat ttttcttgca agtggagcat
    10261 aagattctat ttctacttta gctcctggat acaaaattaa acctttagaa acttttcttc
    10321 cttttggtgt aaatgaaatg ttttcattta cagttacttc aactttacta ttgctgacta
    10381 gagcttcttt tgccagcttt tgaggttcat atgttttatt tatccatatg aaaaagccaa
    10441 gcaaaatcaa tacaaatagt atacctattc ccttaaatat cttattcttt atgttaaatt
    10501 ttctattatt atttttatca tctttgttct caacctcatc ataaagtaaa ggtctctcaa
    10561 gttccatagt tatactaaat gtatcatatt tcttattacg ctttaccttt acatctttac
    10621 tcataaatct aacccccata atatttgaat actattatag tttatcctaa gtaaattgtt
    10681 ttttcaacca atgaaaaaaa tcaatatttt aactattttc atataaaatt cataaatata
    10741 tgttttttgt tttttatata ttattttctt ttagtatttt ataaaacaaa tagccatata
    10801 ctttatttta aatatatggc tattctataa tttaatatct aagctgcttc ttttattgaa
    10861 actttagtta tattacttat tctatacatt tctttgacac catttagagt ttgcagtaag
    10921 tttagacata ttatcttgtc acctagactt ttagtattta caatactctc taaaattaca
    10981 cttcttcctt catcatactt atctacattg taatttgaaa tataattggt atctctcaat
    11041 attttttcaa catcttcatc ttttatttta tttttattaa catttatata tagattatac
    11101 atattactta ttagtaattt ctgattttct aaaaaatcct cttgatgttt atctttatat
    11161 atagcattta tcaacataag tctatcttca ataagtgatg gtatcaataa taaatttttt
    11221 atatagtaaa catcagctac attttctata gacttattga cttcatcaat tatattttta
    11281 actattcctt tatacatttc tataacatgt tgatagcctg ttttagcatc atatggtaat
    11341 ataaacttat ttactattaa tgcaataatt gctcctaatg ctacatatga aatcctgctt
    11401 attgttaaaa catttgggtc tcccataact actgctgaac caagagctga aacagttaca
    11461 cataccatta attttctata atcaactaca taagagttta tataccctgc taaaagaact
    11521 attaacgacc ttaatgtact atcttttatt attgaaaata atacaataaa tattacagct
    11581 cctataaatg taccttctat tctttttcta gacctttgta tacaattttc tgcgtaaggt
    11641 tgtgttaatg aaaagacagt taacattatc catcttccat ctcttaaatg gaaataatcc
    11701 ataataaaac ccgctacagc tgtagctaaa gcaatcttta ctgcataaga aaatcttata
    11761 gaatttaaat taaagttttt cttatatatt gatagtcgtt taaattcatg aggtatcttt
    11821 gattttcttt cagctttctt ttcgtctctt gattttactt ttttataatc tactaaaaac
    11881 tcatataaat tttctaaaac actataaatt tcttttaaat ttatattttt agtatcctga
    11941 gcaataacat aatctctaaa tcctaatatc tctttatcag ttatggtatc tttattttct
    12001 aaacacatct taatatagtt tatttctttc gttgctacaa ctaaaacatc tgatttacta
    12061 tttatgctac tttcttctaa aatatttttt atatcttcat cttcaaattc tttactatcc
    12121 tttttgtatc tttccaggat taaacttatt ctttctaatg aaaataaaat attcattatg
    12181 tctatacctc taatactgat ataaaagtca tcttttctat tatcaaaaat aaccattttc
    12241 aaatttttag atatagaatt tattctataa tta
//
LOCUS       DAEPID010000204         6311 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.guided.139, whole genome shotgun sequence.
ACCESSION   DAEPID010000204 DAEPID010000000
VERSION     DAEPID010000204.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 6311)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6311)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..6311
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.guided.139"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            <1..859
                     /locus_tag="KR257_003870"
     CDS             <1..859
                     /locus_tag="KR257_003870"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861275.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=2
                     /transl_table=11
                     /product="sensor histidine kinase"
                     /protein_id="HBH0032481.1"
                     /translation="YLNWFTKYFSEINQGIDSLIKEDVGEVALSPELLAIEKKINSIK
                     HILEQRKFETQMAEQRKNELIVYLAHDLKTPLTSVIGYLTLLRDESQISEELRKKYLS
                     ISLDKAERLEDLINEFFEITRFNLSNISLEYSTVSLTRMLEQLTYEFKPTLMSKNLKY
                     TLNVTPNMMIRCDVNKMQRVFDNLLRNAVYYSFEDTTIEITAVQEDDYIKLKFINHSN
                     TIPEEKLERIFEQFYRLDTSRNSNSGRAGLGLAIAKEIVELHNGTITAHSENNIITFK
                     VIIPIVGNL"
     gene            1120..2220
                     /gene="vanG"
                     /locus_tag="KR257_003871"
     CDS             1120..2220
                     /gene="vanG"
                     /locus_tag="KR257_003871"
                     /EC_number="6.3.2.35"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_021418924.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="D-alanine--D-serine ligase VanG"
                     /protein_id="HBH0032482.1"
                     /translation="MNNKKIAVIFGGNSTEYDVSLQSAFAVLENLNTEKYDIIPIGIT
                     REGNWYHYIGDYNNIQNNTWFERDTDIIPVIVSQNRVKNGIIEFLIPDAVSQNHIPNS
                     AIESCENDIKYTKLDFVFPVLHGKNGEDGTVQGLFELAGIQVIGCGTLSSALCMDKDK
                     SHKLVHSEGIKVPKSILLKYSDKFNVAELSKDLTYPLFIKPVRAGSSFGISKIYKKEE
                     LQVAVDLAFEHDNEVIIEENIDGFEVGCAVLGNNDLLVGRVDEIELSKGFFDYTEKYT
                     LKSSKIHMPARIDLDCEKRIQETAKIIYRTLGCSGFARVDMFLTPSGEIIFNEVNTIP
                     GFTSHSRYPNMMKGIGLSFEEILDKIIEVYIK"
     gene            2217..3023
                     /locus_tag="KR257_003872"
     CDS             2217..3023
                     /locus_tag="KR257_003872"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436406.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="M15 family metallopeptidase"
                     /protein_id="HBH0032483.1"
                     /translation="MMNNILLDKNKEDKMTNTILLTKDKVYDGNLILVNAFLPVKTSE
                     DIDLIPVDTRFPSILMKREATNILQNILKSICGINEIVPVSGYRTAEEQQDIYSSSLR
                     DNGKDFTKKFVALPNHSEHQTGLAIDLGLKKEVIDFICPEFPYNGICNEFRKAALHYG
                     FIERYQCKKEEITGISQEPWHFRYVGYPHSEIINKMNLALEEYIEYIKRFSYTNCLKI
                     EDKEKIIEIFYVPIHTKEEVRISIPEQCVYQISGNNKDGFIVTFWRNRKD"
     gene            3041..5179
                     /gene="vanT"
                     /locus_tag="KR257_003873"
     CDS             3041..5179
                     /gene="vanT"
                     /locus_tag="KR257_003873"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_021418922.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="serine racemase VanT catalytic subunit"
                     /protein_id="HBH0032484.1"
                     /translation="MIRNKSYAGLDYFRIIAALLIIAIHTSPLLSYSKMADFVLTSII
                     ARIAVPFFFMLSGFFLISTYNYNCNKLKSFLKNVLFIYGIAIVIYIPLNIYTGYFSMN
                     NLVPNIIKDIVFDGTLYHLWYLPASIIGASIAYFLVKKLGLKYSLVITIVIYVIGMFG
                     DSYYGFLEKIPLLKNLYGYIFEVSDYTRNGIFFAPVFFILGGIISNKSNYMSTKNSLI
                     GFLISFLLMLCEGMFLHKLGVQRHDSMYIMLLPCMYFLFTALTFLKGSRARLLRTSSL
                     IIYIIHPMMIVVIRMFSKIFGIQTVLVDNSLIHYIVVSIASFIASIIIILILKPLKKD
                     LKGEHKVNTNRAWIEIDLNNLEHNVKMIQKAMPEDCELMAVVKANAYGHSAFEVATCA
                     NQIGVKAFAVATIDEGIDLRRYGILGEILILGYTNPIRAKELHKYNLTQSVIDLNHAI
                     SLNKQKYNIKSHIKIDTGMHRLGFDVNDVRSILKAFKLKYLDICGIFTHLCVSDSLKD
                     EDVDFTNKQIECFYKLIDFLLKKGIKIPKVHIQSSYGFFNYPNLKCNYVRIGIALYGI
                     LSFPNDTTKLQLDLRPVLSLKSQVILIRKIQKDDSFGYGRVFIASRDSVIAILSIGYA
                     DGIPRNLSCGKSYVIINGCRAAIVGRICMDQLAVDITDIPNVEVGNTAIIIGRDNLSE
                     LSVSEVANNSCSISNELLSRVGRRLNVIKK"
     gene            5493..6113
                     /locus_tag="KR257_003874"
     CDS             5493..6113
                     /locus_tag="KR257_003874"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436409.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TVP38/TMEM64 family protein"
                     /protein_id="HBH0032485.1"
                     /translation="MQYIQELLDLTQNYWVLATIIGLLSAFIESFIPALPLVAIVTAN
                     AAIQGLFIGCLLSWIGSGLGTTSLFLLISRFNDSKLFNKLRNSKTEKAISWMDKQGFK
                     LLFIAYACPFMPGCLVTIASAFGKKDLKDFVPAMLAGKFVMFIVISYVASDIEGFITS
                     PLKIASFILLVFLSWKIGNRVNKNLENHNYDFHHKKHHNDKDDKMI"
BASE COUNT         2325 a          709 c         1074 g         2203 t
ORIGIN      
        1 ttatttaaat tggtttacaa aatattttag tgaaataaat caaggtattg actctcttat
       61 caaagaagat gttggagaag tggctttatc tccagagtta ttggcaatag aaaagaaaat
      121 aaactcaatt aaacatatac ttgaacaacg taaatttgag acacaaatgg cagaacaacg
      181 taagaatgaa cttattgttt atcttgcaca tgatttaaaa acaccactta catcagttat
      241 agggtatctg acactacttc gagatgaaag tcagatttct gaagaactgc gaaaaaaata
      301 tttatctatt tcgttggata aggcagagcg tcttgaagat ttaattaatg aattctttga
      361 aattacaagg tttaatttat caaatatatc acttgaatac agtacagtaa gcttaactcg
      421 tatgcttgaa caactaacat atgagtttaa acctactttg atgagtaaga atttaaaata
      481 tacactgaat gttacaccaa atatgatgat aaggtgtgat gttaataaaa tgcaacgtgt
      541 atttgataac ttattacgaa atgctgttta ttatagtttt gaagatacta ctattgaaat
      601 aacagctgta caggaggatg attatataaa gcttaaattt ataaatcata gcaatacgat
      661 tccagaggaa aaacttgagc gtatttttga acaattttac aggttggata catctcgtaa
      721 ttcaaacagt ggtagagctg ggttgggact tgctatagct aaagaaatag tggagcttca
      781 taacgggaca ataacagctc atagcgagaa caatataatt acctttaagg ttattattcc
      841 gattgtagga aatttgtaag aatttaagta taaaaaaata ggaaattctt taggataaat
      901 aaataaagag cactcttgtt attgatataa ttactgtatc aaaacaagag tgcttttatt
      961 ttgatacagt aattatatca atagaaaaat gtgaaaatat attatgtgga acagatgcaa
     1021 ttgtaagtga aggttgattg gatttgaaat agaaaaagta ttttaacatg tttctgtaga
     1081 ttgtataaaa ataaataaat caacaaagga gaatcaaaga tgaataataa aaaaattgca
     1141 gttatatttg gtggaaactc aacagaatat gatgtatcat tacaatcagc ttttgcagta
     1201 cttgagaatt tgaatacgga aaaatatgat attataccaa ttggaattac aagggagggt
     1261 aattggtatc attatattgg agattataat aatatccaga ataacacttg gtttgaaagg
     1321 gatactgata taattccagt tattgtttcg cagaaccgtg tcaaaaatgg tattattgaa
     1381 tttttaattc ctgatgctgt ttctcagaat catattccaa atagtgctat tgaatcatgt
     1441 gaaaatgata ttaaatacac taaacttgat tttgtgtttc ctgtactgca tggaaaaaat
     1501 ggagaagatg gaacagtgca ggggttattt gaattggcag gtatacaggt tattggatgt
     1561 ggtactcttt cttcagcatt atgtatggac aaagacaaat cacataaact tgttcattca
     1621 gaaggtatta aagtaccaaa atcaatatta ctaaaatact cagataaatt taatgtggct
     1681 gaactgtcaa aagacttaac ttatccatta tttataaaac ctgtgcgtgc aggttcatca
     1741 tttggtatta gtaaaattta taaaaaagaa gagttacaag tagcagtaga cttggctttt
     1801 gaacatgata atgaagtaat aattgaggaa aatattgatg gttttgaggt agggtgtgca
     1861 gttttaggaa acaatgactt acttgttgga agagtagatg aaatagaatt gtcaaaagga
     1921 ttttttgatt atacagaaaa atatacattg aaaagttcaa aaattcatat gccagctaga
     1981 attgatttgg attgtgagaa aagaatacaa gagacagcaa aaattattta tagaactctt
     2041 ggatgttctg gatttgctag agtagatatg tttttaactc catctggtga aattattttt
     2101 aatgaagtca atacaattcc tggctttact tctcatagtc gttatccaaa tatgatgaaa
     2161 ggtattggac tgtcttttga agaaatattg gacaagataa ttgaggtgta cataaaatga
     2221 tgaataatat tttattagat aaaaataaag aagataaaat gacaaatact atcttattga
     2281 ctaaagataa agtttatgat gggaatctaa ttctagtaaa tgctttttta ccagttaaaa
     2341 catctgaaga tatagattta attcctgtag atacaaggtt tccaagtatt cttatgaaac
     2401 gtgaagctac aaacatttta caaaatattt taaaaagtat atgtggaata aatgaaatag
     2461 tacctgtaag tggatatcgt actgcagagg aacaacaaga tatatattca agttctctgc
     2521 gtgacaatgg aaaagacttt actaaaaagt ttgtagcact tccaaatcac agtgaacatc
     2581 agacagggct tgctattgat ttagggttaa agaaagaagt tatagatttt atctgccctg
     2641 aatttcctta taatggtatt tgtaatgagt ttcgtaaggc agcactacat tatggtttta
     2701 tagagcgtta tcagtgtaaa aaagaagaaa taacaggaat atctcaagaa ccatggcatt
     2761 ttcgttatgt gggatatccg cattctgaga ttatcaataa aatgaatctc gctcttgaag
     2821 aatatataga atatattaag agattttcgt atacaaattg tttaaaaata gaagataaag
     2881 aaaaaattat agaaatcttt tatgtgccta ttcatactaa agaagaagtg agaatctcta
     2941 tacctgaaca atgtgtatat caaatatcgg gtaacaataa ggatggtttt attgtgacat
     3001 tttggagaaa tagaaaggac taagaaatgg aggaacaaga atgattagga ataaatctta
     3061 tgcagggctt gattatttta ggattatagc tgcattactt ataattgcaa ttcatacatc
     3121 tccattatta tcatatagta aaatggctga ctttgtgtta actagtataa ttgctcgtat
     3181 tgctgtgcca ttctttttta tgctatcagg cttttttcta atttcaacat ataattataa
     3241 ttgtaataaa ctgaaatctt ttctaaaaaa tgtattattt atttacggga tagctattgt
     3301 aatttatatt cccttaaata tttacactgg atatttttcc atgaataatt tagtgcccaa
     3361 tattattaag gacattgtat ttgatgggac tttatatcat ttatggtatc ttcctgcatc
     3421 aattattggt gcaagtattg catactttct tgtaaaaaaa ctaggtttaa agtactcact
     3481 agtaatcact attgttattt atgtaattgg tatgtttggt gatagttatt atggtttttt
     3541 agaaaaaata ccactattaa agaatttata tgggtatatt tttgaagtat cagattatac
     3601 acgaaatggt atattttttg cacctgtatt tttcatactt ggtggaataa tatctaataa
     3661 atctaattat atgtcaacta aaaatagctt gattggattt cttatatcat tcttacttat
     3721 gttatgtgag ggaatgtttt tacataaact aggggtacag cgtcatgata gcatgtatat
     3781 tatgttattg ccatgtatgt atttcttatt tacagcctta acatttttga aaggttctcg
     3841 agctaggtta ttgcgaacat catcattaat tatttatatt atacatccta tgatgattgt
     3901 tgttattcgt atgttttcta aaatattcgg aatacaaact gtcttggttg acaatagcct
     3961 tattcattat atagtggtaa gtatagcatc ttttatagct tctataatta ttatattgat
     4021 tcttaaacct ctaaaaaaag acttgaaagg agaacataag gtaaatacca atagagcttg
     4081 gattgaaatt gatttaaata atttggaaca taatgtaaag atgatacaaa aagctatgcc
     4141 agaagattgt gaattgatgg cagttgtaaa agctaatgcc tatggtcata gtgcttttga
     4201 agtagcgact tgtgcaaacc aaataggtgt aaaagcattt gcagtagcaa caatagatga
     4261 ggggattgat ttacgtcgat atggaatact aggagaaata ttgattcttg gatatactaa
     4321 cccaataagg gcaaaggaac ttcataaata caatcttaca cagagtgtta ttgaccttaa
     4381 tcatgctatc tctttaaaca aacagaaata caacataaaa tcacacatta aaattgatac
     4441 aggtatgcac agactgggtt ttgatgttaa tgatgtgagg tcaattttaa aggcatttaa
     4501 attaaaatac ttagatatat gtggcatatt tacacacttg tgtgtttcag atagtctgaa
     4561 agatgaagat gtagacttta caaataaaca aattgaatgt ttttataagt taattgattt
     4621 tctgttaaaa aaaggtataa aaattcctaa agtacatatt caaagtagtt atggtttttt
     4681 taattatccc aatcttaagt gtaattatgt aagaattgga attgcattat acgggatatt
     4741 aagttttcca aatgatacga ctaaattgca acttgattta cgacctgttt tatccttaaa
     4801 atcacaagta attcttatta gaaaaataca aaaagatgat agttttggat atggaagagt
     4861 ctttattgca agcagagata gcgtaattgc tatattatct attggctatg ccgatggtat
     4921 acctagaaat ttatcctgtg gaaaaagtta cgtaataata aatggttgta gagcagcaat
     4981 agtgggtcga atttgcatgg accaacttgc tgttgatatt acagatatac ctaatgtaga
     5041 agttggtaat acggcaataa taataggaag agataattta tctgaattat ctgtttctga
     5101 agttgcaaat aactcatgta gtatatcgaa tgaattattg agcagagtag gaagaaggtt
     5161 aaatgttata aagaagtaac tcaattaaat agtaatattt gttgtactgt gtaatttatt
     5221 ttactctgac tagacatttt tagtaatatt atgtctaata tatatttttt ataacttaca
     5281 tgacaattta agttataaaa aggtgatgtt tcagattttt attttgaaac atcacctttt
     5341 ttgttataat atataataaa ataattatac cttaactgta aacttatata gattatttac
     5401 tttttaatat tagattcatt ttttgagatt ggtatataat aaacatatag agtatataat
     5461 aatagttaaa gttaaaaaag gggaaaagca atatgcagta tatacaagaa ctacttgatt
     5521 tgactcaaaa ttattgggtg ttagccacaa taatcggctt attaagtgca tttatagaaa
     5581 gctttatacc agccttacca cttgttgcta tagttacagc aaatgctgca atacaaggat
     5641 tatttattgg atgtttgtta tcatggattg gctcaggact tgggacaact tcattattct
     5701 tattaataag cagatttaat gatagtaagc tttttaataa gttgagaaat agtaaaactg
     5761 aaaaagcaat aagttggatg gataaacagg gatttaagtt attatttata gcgtatgcct
     5821 gtccatttat gcccggttgt ttagttacta tcgcatcagc ttttggtaaa aaagatttaa
     5881 aagattttgt gccagcaatg ttggcaggaa aatttgtaat gtttatagtt ataagttacg
     5941 tggcaagtga tatagaaggt tttataacaa gtcctttaaa gatagcatca tttatattat
     6001 tggtgttttt gtcatggaag attggaaata gagtaaataa aaatcttgaa aatcataatt
     6061 atgatttcca tcataaaaaa catcacaatg ataaagatga taaaatgatt tagcttgtac
     6121 gaaataaaac gtatcttaaa atgatttagt actaaattat tttaagatac gttttatttt
     6181 ttgtattaag gtacaaaatt tttagttctt ttgtaaacta aaatatataa aacttattta
     6241 tacttagttc aaaatattgt tatttatttt ttctacaact ataataaaat ataaaattga
     6301 tatccaatca a
//
LOCUS       DAEPID010000205         4809 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.guided.149, whole genome shotgun sequence.
ACCESSION   DAEPID010000205 DAEPID010000000
VERSION     DAEPID010000205.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 4809)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4809)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4809
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.guided.149"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            278..1231
                     /gene="blaCDD"
                     /locus_tag="KR257_003875"
     CDS             278..1231
                     /gene="blaCDD"
                     /locus_tag="KR257_003875"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434692.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CDD family class D beta-lactamase"
                     /protein_id="HBH0032486.1"
                     /translation="MKRKKNFIWIAILLVGVVMVMYYVGKKHNDINQKTDKNYIKSEL
                     NKSELNKSKIENNDKNKKEKINMVDYSDCFEGISGGAIFYNTKNKEYNIYNKELIETR
                     RSPCSTFKIVSTLIGLEKGVINSKESVMGYDGTEYPNKNWNKNLSLEEAFKESCVWYY
                     KKLIDKVDAKSVQNILDDLKYGNCDISEWEGDLKNGKGHLNGFWLESSLQISPKEQVQ
                     TMAKIFEGDTNFKKEHINILRDIMKIDINDKNINVYGKTGTGFDEKNKRVDAWFVGML
                     EREGDTYYFAIKSDDSNKEITGPKVKEIAINIIKKYYSVRE"
     gene            1575..2258
                     /locus_tag="KR257_003876"
     CDS             1575..2258
                     /locus_tag="KR257_003876"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426268.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBH0032487.1"
                     /translation="MEILKCENLTKIYGSNQTRVTALNNVNLSVQKGDFVSIVGASGS
                     GKSTLLHLLGGVDRPTSGKIYVEDTEISSLKEEALAVFRRRKVGLIYQFYNLIPTLDV
                     RKNILLPMLLDKRKVDEDRFSEIVSILGLSDRLNHLPSQLSGGQQQRVSIARSLIYRP
                     AILLADEPTGNLDRKNSEEIVDLLNLSNKRFNQTILLITHDEKIALEANRIVTMEDGV
                     IVSEKVVKK"
     gene            2255..>4809
                     /locus_tag="KR257_003877"
     CDS             2255..>4809
                     /locus_tag="KR257_003877"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728750.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBH0032488.1"
                     /translation="MNILQEYTLDFVRRNKRSSIAIMLAILLTTTMMSSLCGLLYTMW
                     TDFIRLSIEKEGNWHGELFDYTYGSDLPLIENFSSVDDVMVKGQWYVGKINDEKRDYI
                     IYRNATSEYWNSMPEKDTIIEGRRPNNANEIALSKQYFENNPSVKIGDKITLPIGYRI
                     LNGKPLEPIAPKSKGESFKKISEATLTIVGKVDVSTSSVIPAYTALGYLDKTSIKPND
                     SITVYLRFKNIRDTYKELPKLAKSLGWKTNEYGKYNLKYNSNYLLKMLVFSPEQKASM
                     SSISKFSTPIMYLTIAIFTVAVFVMVIYNAFSLSANARLTQLGILSSVGASPKQIKRS
                     VVFEGFLLTIIPLPIGLFLGWLLCNRLIVYVNSVNYHTDVPEVVFTYGIPAFLPAVLL
                     TIVTVWISALIPARKVSKISPIEAIRQGDSVKIKKSHKYSLGKIFGIEGELASNALRA
                     RKKSYRTATISLTLSFLLLTCFLHIIANQEGAKAVYGSDNYKDQRDIAVYLENSEPIE
                     SAFIEKLDNTEGVKSSLYYQKMSASTWLTEKDASKELAKNGGFKSIVSSKKYSPIERD
                     GKFRIISNIIGLDDKSFTEYCRQISVDPKLFYNTKNPTSIVYNKEEDINRSTRRNKVY
                     IDYLNLSIGDNIKLNEKVYDEDKGDYTYNMKVGAITSTLPKIVDTSSKYTLMQIVPMS
                     MVQEISKNYDEVSRLRSNRLIGVFKVNNREDIPRVREKLESIYNKDYGSGDYSIEDVL
                     ESEKQKASGIKTMNLIVGFITGLLAMIGLSNVLATVSGNIRSRRQEFAMLRSVGLSPE
                     GIKKMLILEGLFLGITPLLLSIPVQIGIVYAFLRINEIYFIEYLPFAPISTIIG"
BASE COUNT         1864 a          547 c          835 g         1563 t
ORIGIN      
        1 attgtaatat ttaaatatta caatagtaag ttttaaatgt ggaatcaatt attatatcac
       61 aaattaaaag gaggacagga tgttattaat agttacctaa ttatcttcgc aataggttta
      121 atcaacataa ttgtactagg tgaagaaaat ataagagata cagctattca tttagtcttg
      181 tttcttataa gtagaaccta gattggagta tattacaaat aatgtctact attttaatag
      241 taggttataa atttaaatat gggagatgat ataaattatg aaaagaaaaa agaattttat
      301 ttggatagct atcttattgg ttggtgtagt tatggtaatg tattatgtag ggaaaaaaca
      361 taacgatata aatcaaaaaa ctgataagaa ttatataaaa tctgaattaa ataagtctga
      421 attaaataaa tccaaaattg aaaacaatga taaaaacaaa aaagaaaaaa ttaatatggt
      481 tgactatagt gattgttttg aaggtattag tggaggagct attttttata atactaaaaa
      541 taaagaatat aatatatata acaaagaatt aattgaaaca agaaggtcac catgttctac
      601 ttttaaaata gtttcaactt taattggttt agaaaaaggg gtaataaact caaaagaatc
      661 agttatggga tatgatggta cagagtatcc aaataaaaat tggaataaaa atcttagttt
      721 agaagaggca tttaaggagt cttgtgtttg gtattacaaa aaattgatag ataaagttga
      781 tgctaaatct gtccaaaaca ttttagatga tttaaagtat gggaattgcg atattagcga
      841 atgggaaggc gatttaaaaa atggaaaggg acatttaaat ggattttggt tagaatcttc
      901 attacaaata tctccaaaag aacaagtgca aacaatggca aaaatatttg agggagatac
      961 aaactttaaa aaagagcata ttaatatttt aagagatatt atgaaaatag atataaatga
     1021 taaaaacata aatgtatatg gaaaaactgg aacaggattt gatgaaaaaa ataaacgtgt
     1081 ggatgcatgg tttgttggta tgctagagcg tgaaggtgac acctattatt ttgctattaa
     1141 atcagatgat tccaataaag aaattacagg gccaaaggta aaggaaattg caattaatat
     1201 aattaagaaa tattatagtg taagggaata aacttaattt tatttgtaaa tattatttac
     1261 ctatagtctg taatatttat taaataattt tactaaattg agtctatata gagcaaaact
     1321 cctttagtac ataaaatact tgctattgat tattaaattg aatacctata gatttaaagt
     1381 taataccttt taaagactat gtaatatatt aaaagtataa ataaaatata ttgcatagtt
     1441 tttgttttat attataattt taaataatgt gcaaaaacta aacaatattt ttaatagtaa
     1501 tttatatttg tattcatgtc actataatgt cattttaggt tgctaaaatt taaccataaa
     1561 ggagatgatt gtatatggaa atattaaaat gtgaaaatct cacaaaaata tatggttcaa
     1621 atcaaaccag agtgacagcc cttaataatg taaatttatc agttcaaaaa ggtgattttg
     1681 tatccattgt aggagcatct ggttctggca aatctacatt gttacatctg cttgggggag
     1741 tagatagacc tacatctgga aagatttatg ttgaagatac agaaatatca agtttaaagg
     1801 aagaagctct tgcagttttt agacgtagaa aagtaggtct tatttatcaa ttttataatc
     1861 ttatacctac ccttgatgtt agaaaaaata tattattacc catgttactt gataaaagaa
     1921 aggtggatga ggatagattc tctgagattg tatctatatt gggattatct gatagattaa
     1981 accatcttcc aagtcaactt tcaggtggac aacaacaaag ggtatctata gctagaagtt
     2041 taatctatag accagctatt ttattagcag atgagccaac tggtaatctt gatagaaaaa
     2101 attcagaaga aattgtagac ttgttaaact tatcaaataa acgatttaat cagacaatac
     2161 ttcttattac tcatgatgag aaaatagcac tagaggcaaa tcgtattgta actatggaag
     2221 atggagtgat tgtctctgaa aaggtggtga agaaatgaat attcttcaag aatacacctt
     2281 agactttgta cgacgcaata aacgtagtag tatagctata atgttagcta tattacttac
     2341 tacaaccatg atgtcttctt tgtgtggact gttgtatacc atgtggacag attttataag
     2401 actttcaatt gagaaagaag gtaactggca tggtgaattg tttgactata cttatggaag
     2461 tgacttacca ttaattgaaa atttttcttc agttgatgat gtaatggtaa aaggacaatg
     2521 gtatgtaggc aaaattaatg atgagaaaag agattatata atttatagaa atgctacatc
     2581 agagtattgg aattctatgc cagaaaagga tactataata gagggtcgtc gaccaaataa
     2641 tgctaatgaa attgcattat caaaacaata ttttgagaat aatccaagtg taaaaattgg
     2701 tgataaaatt actctcccaa taggatatag aatcttaaat ggaaagcctc ttgaacccat
     2761 agccccaaaa tcgaaagggg aaagttttaa aaaaatttca gaggctacat tgacaatagt
     2821 aggaaaggta gatgtttcta cttcatcagt aatacctgca tatacagctc ttggatatct
     2881 tgataaaaca agtataaaac ctaatgatag tataactgtg tacttgcgat ttaaaaatat
     2941 aagagacacg tataaggaac ttccaaaact tgctaaatca ttgggatgga agactaatga
     3001 atatggaaaa tacaatctta aatacaatag taattatctt ttaaagatgt tagtcttttc
     3061 accagaacag aaagcatcta tgagtagtat atcaaaattt tcaactccta ttatgtatct
     3121 tacaatagca atttttacag tagccgtgtt tgtaatggtg atttacaacg cgttttcact
     3181 gtctgcaaat gctagactta ctcagttagg gatattatct agtgttggtg catcaccaaa
     3241 acaaattaaa aggtctgtag tgtttgaagg ctttttactg acaattatac cattaccaat
     3301 aggtttattt ttaggatggt tattgtgtaa taggcttata gtttatgtta attcagttaa
     3361 ttatcatact gatgttccag aagtggtatt tacttatggt attcctgctt ttctgccagc
     3421 agttttactt acaatagtaa cagtctggat ttctgcactt ataccagcac gaaaagtatc
     3481 aaagatatct cctatagaag caatacgaca aggagatagt gttaaaatca aaaagtcgca
     3541 taaatattca ttaggaaaga tatttggaat agaaggagaa cttgcatcaa acgcactacg
     3601 tgctcgtaaa aaatcttatc gtactgcaac aatatcttta acattatctt ttttattact
     3661 tacatgtttt ttgcatataa ttgcaaatca agaaggagca aaagctgttt atggaagtga
     3721 taattataag gaccaaagag atatagcagt ttatttggaa aatagtgaac ctatagagtc
     3781 tgctttcatt gaaaaattag ataatacaga aggtgtaaaa agttcactat attatcaaaa
     3841 aatgtctgct tccacttggc tgactgaaaa agatgcatca aaagaacttg cgaaaaatgg
     3901 aggatttaaa agtatagttt catctaaaaa atactctcct atagaacgtg atggcaagtt
     3961 tcgtataatt tcaaatataa ttgggcttga tgataagagt tttacagaat attgtaggca
     4021 aatttctgta gacccaaagt tattttataa tacaaaaaat ccaacctcaa ttgtatataa
     4081 taaggaggaa gatattaatc gtagtacacg tagaaataaa gtatatatag attatttaaa
     4141 tctttcaata ggagataaca ttaaattaaa tgaaaaagta tatgacgaag ataaagggga
     4201 ttatacttac aacatgaaag tgggagctat tacaagcaca cttcctaaaa tagtagatac
     4261 tagttcaaag tatacattaa tgcaaatagt tccaatgtct atggtacagg aaatatctaa
     4321 aaattatgat gaagtaagta ggttacgttc aaataggctg ataggagtat ttaaagtaaa
     4381 taatcgtgag gacattccta gagtaagaga aaaattagag tccatttata ataaagacta
     4441 tggttcagga gattatagta ttgaggatgt tttagaaagt gaaaaacaaa aggctagtgg
     4501 aataaagacc atgaatttaa tagtaggctt tattacaggt ttattggcta tgattggatt
     4561 atcaaatgta cttgctacag tgtcaggaaa tattagaagt agacgacaag agtttgctat
     4621 gttgcgttct gttggattat ctccagaagg cataaaaaag atgcttattt tggaaggttt
     4681 attcttagga attacaccat tactacttag tattcctgtg caaataggaa tagtgtatgc
     4741 ttttctacgt ataaatgaaa tatattttat agagtattta ccatttgcac ctatatctac
     4801 aataatagg
//
LOCUS       DAEPID010000206         3294 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.guided.167, whole genome shotgun sequence.
ACCESSION   DAEPID010000206 DAEPID010000000
VERSION     DAEPID010000206.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 3294)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3294)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3294
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.guided.167"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            <1..293
                     /locus_tag="KR257_003878"
     CDS             <1..293
                     /locus_tag="KR257_003878"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897777.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=3
                     /transl_table=11
                     /product="nitroreductase family protein"
                     /protein_id="HBH0032489.1"
                     /translation="APKETIDKLFIRNPGMQSLGAAIENFTLSAIELGYGSCWLTSQN
                     YAADEIEAVLEAETGFEKGEYFLGAMLALGVPEDNLKSPSKKPVEEICTFIK"
     gene            708..1424
                     /locus_tag="KR257_003879"
     CDS             708..1424
                     /locus_tag="KR257_003879"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861605.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HBH0032490.1"
                     /translation="MNSYNILVVEDEKEIADAIEIYLLNQGYNVFKGYNGLEGLKVIE
                     NQEIHLAIVDIMMPKMDGITLTMKLRENYNFPVIMLSAKSEEVDKIMGLNIGADDYVT
                     KPFKPLELLARVNSQLRRYTKYLNMVGNKEQKVESDDSVFAIGGLELNENTKEVSIDG
                     KYIKTTPIEFKILSLLMRNAGRVFSADEIYERVWNENAVNTDTVMVHVRNIREKIEID
                     PKNPKYLKVVWGVGYKIEKI"
     gene            1399..>3294
                     /locus_tag="KR257_003880"
     CDS             1399..>3294
                     /locus_tag="KR257_003880"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897776.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sensor histidine kinase"
                     /protein_id="HBH0032491.1"
                     /translation="MDTKLKKFKDKYIVTIIVFILMLSASLGMISQYSTIQASAKGGA
                     ENPFEQESFVDSIYKGSYVLYHNMKEEQEGKMIQPSKLFINEETMNYIKNVSKEKDTY
                     DGSETYYTDDSINADFNENFENWEHFIKASGKNLKYYLVDKESNFEFFNDNKELGVLD
                     TTKNDASKENSNENQSKNTEMNDEERQKQITDIKENYRFYVVMNFDKDGKVNIVDSYG
                     VNQKIINQMLLSKAREDLMDTSLGGNSISYKLSPIKNITLVYAVPKVISKGDSVEYGY
                     GNTYFDDGIISYISNVENNSYYKISGMILKIILAIVVIVALAFPYRKSKELLGFDTLS
                     RIPLEILFIALAIIQGLVDLYPTVIISNTLSGNYVEYLINNDISAKMASILVSLMNLT
                     YWFVIFSIIFVFIILLKHILNVGIREYFTKHTVTGMFFVWLKKAGKAVINQIRTINLK
                     EKPNKTIVTILGINLLIIVIMCSMWFFGIILALIYSVVLFKILSDYSKKTIYEYNQLL
                     DVTKKISDGNLDVNMEKDLGFFNPIKDELGNIQTGFKKAVDEEVKSQKMKTELISNVS
                     HDLKTPLTSIITYIDLLKDESITDENRKLYIDTLDRKSQRLQHLIEDLFEVSKANSGD
                     VYLNIVNV"
BASE COUNT         1388 a          296 c          560 g         1050 t
ORIGIN      
        1 atgcacctaa ggagactata gataaattat ttataagaaa tccaggtatg cagagtctag
       61 gtgctgcaat tgaaaacttt acactatcag caattgaact tggatatggt tcttgttggt
      121 tgacaagtca aaactatgca gcagatgaga tagaagctgt tttagaagca gaaactggtt
      181 ttgaaaaggg agagtatttt ttaggtgcaa tgttagctct tggagtgcca gaggacaatt
      241 tgaagagtcc atctaaaaaa ccagtagaag aaatatgtac atttataaaa taaaagtcaa
      301 ggacatttta aaatcgaagt aaattaaaaa caaaataaat taaaaataaa tatttaaaaa
      361 attaaaaagt aggttttatt gatattaatt ttatatttca aatcattaat ttaattaata
      421 caataagaac tacttttttt tgtatattaa ttttaaatat atttaaatct ttagaaaatc
      481 tttagaaaag tatatgtaat atcttaagtt tttaatttta atattaagta tataaaacaa
      541 aatgaaaaaa tattaaattt aaactagaag gaggtttcta agatggacat taaatacaaa
      601 taaccagaac aaaagatata aatatatata taaatggaaa aacttctatc atattgtata
      661 atcatatatg taaagaaaat ttataaatta atataaagga gattagaatg aattcatata
      721 atattttggt ggtagaagat gaaaaggaga tagcagatgc tatagaaata tatctattaa
      781 atcaaggata taatgttttt aagggataca atggattaga aggtcttaag gttatagaaa
      841 accaagaaat acatttagct atagttgata taatgatgcc taaaatggat ggtataacac
      901 ttacaatgaa gcttagagaa aactataatt ttccagtaat aatgctatct gcaaaatcag
      961 aagaagttga caaaataatg gggcttaata taggagcaga cgattatgta acaaaacctt
     1021 ttaagccatt agaactattg gctagagtta attcacaact tagaaggtac actaagtatc
     1081 taaacatggt tggaaataaa gagcaaaagg tagaaagtga cgatagtgtg tttgcaatag
     1141 gcggattaga attaaatgaa aatacaaaag aagttagtat tgatggaaag tatataaaaa
     1201 caactcctat agaatttaaa atactaagtt tacttatgag aaatgcagga agagtttttt
     1261 ctgctgatga aatatatgaa agagtttgga atgagaatgc tgtaaataca gatacagtta
     1321 tggtacatgt gaggaatata agggaaaaga tagaaattga cccaaaaaat cctaaatatt
     1381 taaaggtggt gtggggtgtt ggatacaaaa ttgaaaaaat ttaaagataa atatatagtt
     1441 actattatag tttttatact tatgttatca gcatcattag gtatgattag tcaatattct
     1501 actatacaag caagtgctaa aggtggagca gagaatccat ttgaacagga aagctttgta
     1561 gatagtatat ataaaggaag ttatgtttta tatcataata tgaaggaaga acaagaaggt
     1621 aagatgatac aaccatcaaa gctatttatc aatgaagaaa ctatgaacta tataaaaaat
     1681 gtaagtaaag aaaaagatac ttatgatggt tcagaaactt attatacaga tgatagtatt
     1741 aatgcagatt ttaatgaaaa ctttgaaaat tgggagcatt tcattaaagc gtcaggaaag
     1801 aatttaaagt actatttagt tgataaagaa agcaattttg aattttttaa tgataataaa
     1861 gaattaggag tacttgatac aacaaaaaat gatgcttcaa aagaaaattc taatgaaaat
     1921 cagtcaaaaa atacagaaat gaatgatgag gaaagacaaa agcagattac agatataaaa
     1981 gaaaactata gattctacgt tgtaatgaat tttgataaag atggaaaagt aaatattgtg
     2041 gattcttatg gagtaaatca aaaaattatt aatcaaatgt tgttatctaa agcaagagaa
     2101 gatttaatgg atacaagttt aggaggaaat tcaatttcat ataagttatc tccaataaaa
     2161 aatataacat tagtatatgc tgtacctaaa gtaataagta aaggtgatag tgtagagtat
     2221 ggttatggaa atacttattt tgatgatggt ataatttcat atataagcaa tgtagaaaat
     2281 aattcttatt ataagatttc tggaatgatt ttaaaaatta tattagctat agttgttatt
     2341 gtagctttag cattcccata tagaaaatct aaagagttgc taggatttga tacattatca
     2401 agaataccgt tagagatact ctttattgct cttgctatta tacaggggct tgtagattta
     2461 tatcctactg ttataataag taataccttg agtgggaatt atgtagagta ccttataaac
     2521 aatgacataa gtgctaaaat ggctagtata ttggtaagtt taatgaattt aacttattgg
     2581 tttgtaatat tctcaataat atttgtattt ataatacttt taaaacacat tttaaatgtt
     2641 ggaataagag agtattttac aaaacatact gtgacaggaa tgttttttgt atggttaaaa
     2701 aaagcaggaa aagcagttat taatcaaatt agaacaataa atctgaaaga aaagccaaat
     2761 aaaactatag ttacaatttt gggaataaat ttattgatta tagttataat gtgtagtatg
     2821 tggttctttg gaataatact cgcattaata tattcagtag tattatttaa gatactgtca
     2881 gattactcta aaaagacaat atatgaatat aatcaacttt tagatgttac aaagaaaatt
     2941 tcagatggaa acttagatgt aaatatggaa aaagatttag gattttttaa tcctataaaa
     3001 gatgaattag gaaatattca aactggattt aaaaaagctg ttgacgaaga ggttaagagt
     3061 caaaagatga aaacagagct tatatcaaat gtatcacatg acttaaaaac acctctaaca
     3121 tctataatca cttatataga tttattaaaa gatgaaagta taacagatga aaatcgtaag
     3181 ttgtatattg atacattaga cagaaagtca caaagattgc aacatctaat agaagatttg
     3241 tttgaagtaa gcaaggcaaa tagtggagat gtttatttga atatagtaaa tgtg
//
LOCUS       DAEPID010000207         1049 bp    DNA     linear   BCT 17-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain 21A10CD0043
            SAMN05941516-rid12469663.guided.202, whole genome shotgun sequence.
ACCESSION   DAEPID010000207 DAEPID010000000
VERSION     DAEPID010000207.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN05941516
            Sequence Read Archive: SRR6243589
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 1049)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1049)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 12-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001068150.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001068150.1
            Genome Coverage       :: 257x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/13/2021 00:38:09
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,881
            CDSs (total)                      :: 3,809
            Genes (coding)                    :: 3,760
            CDSs (with protein)               :: 3,760
            Genes (RNA)                       :: 72
            rRNAs                             :: 8, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 19 of 49
            Pseudo Genes (incomplete)         :: 27 of 49
            Pseudo Genes (internal stop)      :: 11 of 49
            Pseudo Genes (multiple problems)  :: 6 of 49
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1049
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN05941516-rid12469663.guided.202"
                     /strain="21A10CD0043"
                     /isolation_source="stool sample (feces)"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Canada"
                     /collection_date="2010"
                     /collected_by="Canadian Nosocomial Infection Surveillance
                     Program"
     gene            76..777
                     /locus_tag="KR257_003881"
     CDS             76..777
                     /locus_tag="KR257_003881"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_021418928.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="VanG-Cd-type vancomycin resistance DNA-binding
                     response regulator VanR"
                     /protein_id="HBH0032492.1"
                     /translation="MNENILIVDDEKEIADLIEVYLKNEGFTVYKFYTGKEALECIES
                     KNLDMAILDIMLPDIDGFHICQKIREKYYYPIIMLTAKIEDIDKIMGLTIGADDYITK
                     PFNPLEVVARVKTQLRRYMRYNNSYEQQSIIVNEYDIKGLIINKETHKCSLFGKEVAL
                     TPIEFSILWYLCEHQGKVVPSEELFEAVWGEKYLDNNNTVMAHIGRLREKIHEPSKNP
                     KFIKTVWGVGYTIEK"
BASE COUNT          389 a          109 c          185 g          366 t
ORIGIN      
        1 tgtaattatt tgatatgtaa atttaccaat attataaatg atgacctcga taataaggag
       61 agtgaaaaat aatctatgaa cgaaaatatt ttgattgtgg atgatgaaaa agaaatagca
      121 gatttaattg aagtatattt aaaaaatgaa ggttttacag tatacaagtt ttatacaggt
      181 aaggaagctc tagaatgtat tgaatctaaa aatttggata tggctatttt agatattatg
      241 cttcctgata ttgatggatt tcatatttgc cagaaaattc gagaaaaata ctattatcct
      301 atcattatgt taacagctaa aattgaagat atagacaaga taatgggttt aaccataggt
      361 gctgatgatt atataacaaa gccatttaac cctttggaag ttgttgcaag agtaaagaca
      421 caattaagaa gatatatgcg atataataat tcttatgaac aacagtcgat aattgttaat
      481 gagtatgata ttaaaggatt gattatcaat aaagaaacac ataaatgtag tttatttggg
      541 aaagaagtag cattaacacc gattgaattt tctattcttt ggtatttatg tgaacatcaa
      601 ggaaaagtgg ttccttctga agaattgttt gaagctgtat ggggagaaaa atatcttgat
      661 aataataaca cagttatggc tcatataggg cgattacgtg aaaaaattca tgaaccttct
      721 aaaaacccga aatttataaa aactgtatgg ggagtaggtt atacaattga aaagtaaaaa
      781 tattaaagtc aatcctgact ttactcaagt gagaaataaa atttttatga gaacagcttt
      841 aatggcattt atagccatta ttttcatatg gattttatat tcttttatat tgtatggtaa
      901 gttttctatc tggatagtat cattctttga aaatgctttt cgtatggaat ataaagctgc
      961 attgaattta tatcagcaga ttttccgtaa tagtatggag ctcttcatga tactagctat
     1021 ggtgattgtg ttttttataa tattccgtg
//
